diff --git a/interpro_active_site/advanced/idx2term.json b/interpro_active_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_active_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_active_site/basic/idx2term.json b/interpro_active_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_active_site/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_active_site/consensus.joblib b/interpro_active_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..17351d43e9cb4eeaa83a8be1845bb03f067121ec --- /dev/null +++ b/interpro_active_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:b8d7a1d91807100691223e251550244a96d5903a69799691d962914d59e39e78 +size 64098 diff --git a/interpro_active_site/df_merge.tsv b/interpro_active_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..dd1ebfd47b9e5d959f2adf722e930f502d75b412 --- /dev/null +++ b/interpro_active_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_active_site/metrics.json b/interpro_active_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..2413145559644de12d57111c820cdc4968b3b135 --- /dev/null +++ b/interpro_active_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2453, + "annotations_size": 50, + "title": "Average number of proteins per term", + "value": 2.3 +} \ No newline at end of file diff --git a/interpro_active_site/paths.json b/interpro_active_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..dd9db94aeeb1d388f6f773f65c95417fa1888cc2 --- /dev/null +++ b/interpro_active_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C334/C334_val_log2fc"} \ No newline at end of file diff --git a/interpro_active_site/result.tsv b/interpro_active_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..9fc9246d5de74680007135c27f653f148640a4e7 --- /dev/null +++ b/interpro_active_site/result.tsv @@ -0,0 +1,5 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Serine carboxypeptidase, serine active site [IPR018202] 0.9832653061224488 2.1844510853271144 0.0289291178825092 0.7695659819330224 0.0628893867011071 3 Q9HB40,Q9H3G5 2 +Ubiquitin-conjugating enzyme, active site [IPR023313] 0.7787886166376339 1.415293996909455 0.1569823143742201 0.9998041902611844 0.2180309921864169 6 P49427 1 +Ubiquitin-activating enzyme E1, Cys active site [IPR033127] 0.7253849628519947 1.1881481513131145 0.2347750466586888 0.9999984531215892 0.2863110325105962 3 Q8TBC4 1 +Cysteine peptidase, cysteine active site [IPR000169] 0.6530172549227458 0.9074182683618912 0.3641856524321878 0.9999999998532708 0.423471688874637 3 P17655 1 diff --git a/interpro_active_site/selections.json b/interpro_active_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..3708ac2aea8d94054adb75590eb247f9aadf3a3f --- /dev/null +++ b/interpro_active_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenylosuccinate synthase, active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Cysteine peptidase, cysteine active site [IPR000169]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]", "Uracil-DNA glycosylase, active site [IPR018085]"], "available_proteins": ["ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADSS", "AKT2", "APEH", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "BLMH", "CAMK2D", "CAMK2G", "CAPN1", "CAPN2", "CDC34", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CTSA", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "EPHA7", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLUD1", "GSK3A", "GSK3B", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "LDHA", "LDHB", "LONP1", "MAP2K1", "MARK2", "MDH1", "MDH2", "MTMR6", "NEK9", "NME1", "PAK2", "PBK", "PGAM1", "PKM", "PKN2", "PLK1", "PREP", "PRKACA", "PRPF4B", "PTK7", "PTPN1", "RIPK1", "RNASET2", "ROCK2", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SRPK2", "SUCLG1", "TALDO1", "TIGAR", "TOP1", "TPI1", "TPP2", "TTK", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "UMPS", "UNG", "VRK1"], "leading_proteins": ["CAPN2", "CDC34", "CPVL", "SCPEP1", "UBA3"]} \ No newline at end of file diff --git a/interpro_binding_site/advanced/idx2term.json b/interpro_binding_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_binding_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_binding_site/basic/idx2term.json b/interpro_binding_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..1f2df466d020a9613ebb803cec2bf89e8e4d80ca --- /dev/null +++ b/interpro_binding_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "EF-Hand 1, calcium-binding site [IPR018247]"} \ No newline at end of file diff --git a/interpro_binding_site/basic/plot_0.png b/interpro_binding_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..09544a99bc0400ec7360801a1c410acea237ea1d --- /dev/null +++ b/interpro_binding_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:40d85498c42083d90c75a73bd211136c8bd2a45f72212f845d4bdeb4cc07d449 +size 136414 diff --git a/interpro_binding_site/consensus.joblib b/interpro_binding_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..4c96d1f46690c6eb36c658d0a99155e112c189ae --- /dev/null +++ b/interpro_binding_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:2084170ae3a8fcc7537bc373b637d0ad12d8657fbf83a5774cbd9752b7001f17 +size 56711 diff --git a/interpro_binding_site/df_merge.tsv b/interpro_binding_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..dd1ebfd47b9e5d959f2adf722e930f502d75b412 --- /dev/null +++ b/interpro_binding_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_binding_site/metrics.json b/interpro_binding_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..379710189bbff32cb81b8e4d0c2477a4391ad0d2 --- /dev/null +++ b/interpro_binding_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2453, + "annotations_size": 27, + "title": "Average number of proteins per term", + "value": 4.111111111111111 +} \ No newline at end of file diff --git a/interpro_binding_site/paths.json b/interpro_binding_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..657acc328279eb0bc6c892577f67aff8fb0f2a0a --- /dev/null +++ b/interpro_binding_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C334/C334_val_log2fc"} \ No newline at end of file diff --git a/interpro_binding_site/result.tsv b/interpro_binding_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..69aeedfdb94024c6b6bf5af6e3b3c2489bde9367 --- /dev/null +++ b/interpro_binding_site/result.tsv @@ -0,0 +1,5 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +EF-Hand 1, calcium-binding site [IPR018247] 0.4669995366274244 1.1483763289934366 0.2508132412143116 0.9995889141662648 0.3721566610900477 32 Q02818,Q9Y680,P80303,Q9BRK5,Q9NWM8,Q14257,O43852 7 +Beta tubulin, autoregulation binding site [IPR013838] 0.647284226753204 0.8953518470013279 0.3705990328579616 0.9999962757402812 0.5003086943582482 4 Q9BUF5,P68371 2 +PPM-type phosphatase, divalent cation binding [IPR000222] 0.431660546715627 0.3263530009694156 0.7441572923142696 1.0 0.8735759518471861 2 Q9H0C8 1 +Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349] 0.348429212566299 0.1297100739228039 0.8967958120689681 1.0 0.9505837334249464 2 P50579 1 diff --git a/interpro_binding_site/selections.json b/interpro_binding_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..7adcf5075c3e57df0f257fcfee8e06412c39020e --- /dev/null +++ b/interpro_binding_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Protein kinase, ATP binding site [IPR017441]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]", "Ureohydrolase, manganese-binding site [IPR020855]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT2", "APEX1", "ARG2", "CALU", "CAMK2D", "CAMK2G", "CAPN1", "CAPN2", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "COX2", "COX5B", "CSK", "CSNK1A1", "CYB5B", "DLAT", "DLST", "DST", "EHD1", "EIF2AK2", "EPHA7", "FKBP10", "FKBP14", "FKBP7", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "GSK3B", "HK1", "HK2", "IDE", "ILKAP", "IQGAP1", "LETM1", "MACF1", "MAP2K1", "MARK2", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH14", "MYH9", "MYO1B", "MYO1C", "NRDC", "NUCB1", "NUCB2", "PA2G4", "PAK2", "PAK4", "PC", "PCCA", "PDCD6", "PDHX", "PEF1", "PGD", "PKN2", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PPM1G", "PRKACA", "PRKCSH", "PSAT1", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK2", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SRI", "SRPK1", "SRPK2", "TKT", "TTK", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["CALU", "FKBP14", "FKBP7", "ILKAP", "METAP2", "NUCB1", "NUCB2", "RCN2", "SDF4", "TUBB4B", "TUBB6"]} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/idx2term.json b/interpro_conserved_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_conserved_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_conserved_site/basic/idx2term.json b/interpro_conserved_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..0b9bbc0dc52433ecdf0b1249a61504387474e680 --- /dev/null +++ b/interpro_conserved_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "DnaJ domain, conserved site [IPR018253]"} \ No newline at end of file diff --git a/interpro_conserved_site/basic/plot_0.png b/interpro_conserved_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..287c80c5e76039da6b89ccc68101db3651e5d2e9 --- /dev/null +++ b/interpro_conserved_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:943fea46116c87ba4c717b4c0919b0604f1463c1aadb9918df5a0a2a668eab1a +size 139955 diff --git a/interpro_conserved_site/consensus.joblib b/interpro_conserved_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..2481d1913d7d9e33820c833fcfbf5b6824e557fc --- /dev/null +++ b/interpro_conserved_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:5309d8ab2074e7846de67cc76b1f7f40d3229d4a209f590f3916782c72ecbd23 +size 106617 diff --git a/interpro_conserved_site/df_merge.tsv b/interpro_conserved_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..dd1ebfd47b9e5d959f2adf722e930f502d75b412 --- /dev/null +++ b/interpro_conserved_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_conserved_site/metrics.json b/interpro_conserved_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..0f3874275eb5ffb7ced52a370d136b7cbe8cb1bf --- /dev/null +++ b/interpro_conserved_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2453, + "annotations_size": 252, + "title": "Average number of proteins per term", + "value": 2.488095238095238 +} \ No newline at end of file diff --git a/interpro_conserved_site/paths.json b/interpro_conserved_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..02a44464d7c90a339be2db8874c7603ce17a22e9 --- /dev/null +++ b/interpro_conserved_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C334/C334_val_log2fc"} \ No newline at end of file diff --git a/interpro_conserved_site/result.tsv b/interpro_conserved_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..1f6aa1081a80b29127ce0572d8abc2f42297187f --- /dev/null +++ b/interpro_conserved_site/result.tsv @@ -0,0 +1,26 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Proteinase inhibitor I2, Kunitz, conserved site [IPR020901] 0.9885760913912692 2.6753035812734915 0.0074661608491912 0.848706160965601 0.024121442743541 2 P05067 1 +Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745] 0.9885760913912692 2.6753035812734915 0.0074661608491912 0.848706160965601 0.024121442743541 2 P05067 1 +Amyloidogenic glycoprotein, copper-binding domain conserved site [IPR019744] 0.9885760913912692 2.6753035812734915 0.0074661608491912 0.848706160965601 0.024121442743541 2 P05067 1 +Sterol reductase, conserved site [IPR018083] 0.9616483068135456 2.5648678457427954 0.0103215108791778 0.9267983311529204 0.0295570538812821 2 Q9UBM7 1 +Immunoglobulin/major histocompatibility complex, conserved site [IPR003006] 0.8282333741330108 1.9986844474918877 0.0456425068041348 0.9999922875189244 0.0891621063150541 2 P01889 1 +Phosphorylase pyridoxal-phosphate attachment site [IPR035090] 0.7719298245614039 1.7510283358843262 0.0799410292003692 0.9999999992387149 0.1316675775064905 2 P06737 1 +Clathrin adaptor complex, small chain [IPR000804] 0.7535699714402292 1.66937289247492 0.0950435024040485 0.9999999999882462 0.1469384208946026 2 Q92572 1 +Ubiquitin conserved site [IPR019954] 0.7405140758873907 1.6110886264619335 0.1071604069581178 0.9999999999996064 0.161703129062549 2 P54578 1 +Guanylate kinase, conserved site [IPR020590] 0.7372501019991827 1.5964925149998066 0.1103788755717178 0.9999999999998416 0.1655683133575768 2 Q9NZW5 1 +Chromo domain, conserved site [IPR023779] 0.7681632653061208 1.3561700717575036 0.1750450620131087 1.0 0.2433570165916223 3 Q13185,P83916 2 +Proteasome beta-type subunit, conserved site [IPR016050] 0.6356447469755057 1.1863670819913763 0.235477365564606 1.0 0.3074626742087084 8 P49721 1 +HMG box A DNA-binding domain, conserved site [IPR017967] 0.7081632653061198 1.1207378616779338 0.2623994608856168 1.0 0.3373707354243644 3 P09429,P26583 2 +Thioredoxin, conserved site [IPR017937] 0.5638601665157765 1.0771752219801525 0.2814019926378215 1.0 0.3563482519835729 10 Q8IXB1,O95881 2 +Fumarate lyase, conserved site [IPR020557] 0.6128110975112225 1.0386982243072451 0.298945107265685 1.0 0.3766708351547631 2 P07954 1 +Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326] 0.6119951040391707 1.035083071896298 0.3006301174293593 1.0 0.3769094009562116 2 P29692 1 +DnaJ domain, conserved site [IPR018253] 0.5810631112701902 0.961265162551797 0.3364188596328481 1.0 0.4155762383699888 8 Q96KC8,Q99543,O60884,P25685,Q8WXX5 5 +Tubulin, conserved site [IPR017975] 0.6472842267532041 0.8953518470013279 0.3705990328579616 1.0 0.4489949821163765 4 Q9BUF5,P68371 2 +Cyclic nucleotide-binding, conserved site [IPR018488] 0.5675234598123262 0.8408496680166104 0.4004321582060826 1.0 0.4782412505589232 2 P10644 1 +Adenylate kinase, conserved site [IPR033690] 0.6237074509132184 0.7967947918201885 0.4255702203707314 1.0 0.5058664883652091 3 P00568 1 +14-3-3 protein, conserved site [IPR023409] 0.599906925792536 0.7512313710685726 0.4525134234476908 1.0 0.5303878265526423 6 P27348 1 +Vinculin, conserved site [IPR000633] 0.5442676458588388 0.7423626724236888 0.4578676291964723 1.0 0.5317172468088065 2 P35221 1 +Ribosomal protein L3, conserved site [IPR019926] 0.4887800897592868 0.5215199899447817 0.6020045838370467 1.0 0.6683046481362809 2 P09001 1 +Zinc finger, RING-type, conserved site [IPR017907] 0.3592205580043279 0.2484838372633038 0.8037600740064978 1.0 0.8439480777068228 10 Q14527 1 +Tr-type G domain, conserved site [IPR031157] 0.3427287581699368 0.0741617223843575 0.9408817030559172 1.0 0.952217627189121 5 Q05639,P15170,P49411,Q96RP9 4 +Clathrin adaptor, mu subunit, conserved site [IPR018240] 0.2975510204081585 0.0406692397107033 0.9675595844528986 1.0 0.971414403514464 3 Q96CW1,Q9Y2T2 2 diff --git a/interpro_conserved_site/selections.json b/interpro_conserved_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..7db8bc631dec60eb3edad0de951d5fb64e24b8a2 --- /dev/null +++ b/interpro_conserved_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Amyloidogenic glycoprotein, copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Bromodomain, conserved site [IPR018359]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific, conserved site [IPR031303]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "Homeobox, conserved site [IPR017970]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Lysophospholipase patatin, conserved site [IPR001423]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RIO kinase, conserved site [IPR018935]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P, conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class V, conserved site [IPR001426]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]"], "available_proteins": ["AAAS", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ACAA2", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP3M1", "AP3S1", "APEX1", "APLP2", "APP", "ARIH2", "ATAD1", "ATP5C1", "ATP5O", "BAG6", "BAZ1A", "BAZ1B", "BAZ2A", "BCAT2", "BLM", "BOP1", "BPTF", "BRCA1", "BRD2", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CBR1", "CBX1", "CBX3", "CBX5", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDKAL1", "CECR2", "CHAF1B", "CHD4", "CLGN", "CMPK1", "CNDP2", "COPA", "COPZ1", "CORO1B", "CORO1C", "CPOX", "CRYZ", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CYP51A1", "DCAF13", "DCAF7", "DCPS", "DCXR", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX6", "DHCR7", "DHFR", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX38", "DHX40", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DRG1", "DRG2", "DSG2", "DST", "DTYMK", "DYNLL1", "ECH1", "ECHS1", "ECI2", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "ENO1", "EPB41", "EPB41L2", "EPHA7", "EPRS", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXC1", "FOXK1", "FUCA2", "GAA", "GALK1", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GMPPA", "GNPDA1", "GNS", "GPI", "GRHPR", "GRWD1", "GSPT1", "GTF3C2", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HOXA10", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "ILVBL", "IMPDH2", "INA", "IQGAP1", "IVD", "KDM2A", "KDSR", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "LAMP1", "LARS", "LARS2", "LBR", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRWD1", "LSS", "MACF1", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "ME2", "MGST2", "MID1", "MIF", "MPI", "MPP2", "MPP6", "MPST", "MRPL24", "MRPL3", "MRPS11", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFV1", "NEFL", "NEFM", "NES", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD2", "NSF", "NUBP2", "NUDT1", "NUDT12", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL6", "OSBPL9", "P4HB", "PAFAH1B1", "PAICS", "PBRM1", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHGDH", "PHIP", "PI4KB", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PNP", "PNPLA6", "POLD1", "POLR1B", "POLR1C", "POLR2B", "POLR2E", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RCL1", "RDH13", "RDX", "RECQL5", "RIOK2", "RNF114", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSF1", "RTN4IP1", "S100A10", "S100A11", "SART1", "SBDS", "SCD", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A4", "SLIT2", "SMARCA4", "SMU1", "SNRNP40", "SNU13", "SPATA5", "SPTBN1", "SRCAP", "SRM", "STMN1", "STRN4", "STX12", "STX18", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SYNE2", "TAP1", "TAP2", "TBL3", "TCP1", "THOC6", "TK1", "TLN1", "TMX1", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TSFM", "TSPAN6", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UHRF1", "USP10", "USP14", "USP36", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4B", "WARS", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR36", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2"], "leading_proteins": ["AK1", "AP2M1", "AP3M1", "AP3S1", "APP", "CBX1", "CBX3", "CTNNA1", "DHCR7", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC2", "DNAJC9", "EEF1A2", "EEF1D", "FH", "GFM1", "GSPT1", "HLA-B", "HLTF", "HMGB1", "HMGB2", "MPP6", "MRPL3", "PRKAR1A", "PSMB2", "PYGL", "TUBB4B", "TUBB6", "TUFM", "TXNDC12", "USP14", "YWHAQ"]} \ No newline at end of file diff --git a/interpro_domain/advanced/idx2term.json b/interpro_domain/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_domain/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_domain/basic/idx2term.json b/interpro_domain/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..e13e5279d38f15695e3db668d5894ba55559d31f --- /dev/null +++ b/interpro_domain/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "K Homology domain [IPR004087]", "1": "Importin-beta, N-terminal domain [IPR001494]", "2": "K Homology domain, type 1 [IPR004088]", "3": "DnaJ domain [IPR001623]", "4": "EF-hand domain [IPR002048]", "5": "PDZ domain [IPR001478]", "6": "Translational (tr)-type GTP-binding domain [IPR000795]", "7": "Translation elongation factor EFTu-like, domain 2 [IPR004161]", "8": "Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) [IPR002314]"} \ No newline at end of file diff --git a/interpro_domain/basic/plot_0.png 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@@ +version https://git-lfs.github.com/spec/v1 +oid sha256:a206c75df692166d8c7c34627a4c6f866b664cb846135522aea5d20041041f3e +size 144440 diff --git a/interpro_domain/basic/plot_8.png b/interpro_domain/basic/plot_8.png new file mode 100644 index 0000000000000000000000000000000000000000..68960c0b819c3686e7bcad9f8311c81c62c566f3 --- /dev/null +++ b/interpro_domain/basic/plot_8.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:bc12c5a081880b742420578263f8b3765984cf33f2558859f6fdc5181b6c18e1 +size 151643 diff --git a/interpro_domain/consensus.joblib b/interpro_domain/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..1643dd9c2e555349c8340889a6d8a3f84416396f --- /dev/null +++ b/interpro_domain/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:476eebb9bc2fe951212863b434a1b3ca39be787a91496867159f3fbc7e42dfd2 +size 535145 diff --git a/interpro_domain/df_merge.tsv b/interpro_domain/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..dd1ebfd47b9e5d959f2adf722e930f502d75b412 --- /dev/null +++ b/interpro_domain/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_domain/metrics.json b/interpro_domain/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..b5aec641d5111c3efa4abf0d91c7d8720853ca7e --- /dev/null +++ b/interpro_domain/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2453, + "annotations_size": 2199, + "title": "Average number of proteins per term", + "value": 2.049567985447931 +} \ No newline at end of file diff --git a/interpro_domain/paths.json b/interpro_domain/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..0de56bc802f769d25fb1fa402d91a7ada3afedc2 --- /dev/null +++ b/interpro_domain/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C334/C334_val_log2fc"} \ No newline at end of file diff --git a/interpro_domain/result.tsv b/interpro_domain/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..df617472bbad25fc14b7a8841be51a017a4f9107 --- /dev/null +++ b/interpro_domain/result.tsv @@ -0,0 +1,173 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +MD-2-related lipid-recognition domain [IPR003172] 0.9930640554875564 2.693582346947124 0.007068868125083 0.9999998320571514 0.0204801594295883 2 P61916 1 +Amyloidogenic glycoprotein, heparin-binding [IPR015849] 0.9885760913912692 2.6753035812734915 0.0074661608491912 0.999999930343132 0.0212088416332463 2 P05067 1 +Pancreatic trypsin inhibitor Kunitz domain [IPR002223] 0.9885760913912692 2.6753035812734915 0.0074661608491912 0.999999930343132 0.0212088416332463 2 P05067 1 +Amyloidogenic glycoprotein, E2 domain [IPR024329] 0.9885760913912692 2.6753035812734915 0.0074661608491912 0.999999930343132 0.0212088416332463 2 P05067 1 +Amyloidogenic glycoprotein, copper-binding [IPR011178] 0.9885760913912692 2.6753035812734915 0.0074661608491912 0.999999930343132 0.0212088416332463 2 P05067 1 +Beta-amyloid precursor protein C-terminal [IPR019543] 0.9885760913912692 2.6753035812734915 0.0074661608491912 0.999999930343132 0.0212088416332463 2 P05067 1 +Amyloidogenic glycoprotein, extracellular [IPR008154] 0.9885760913912692 2.6753035812734915 0.0074661608491912 0.999999930343132 0.0212088416332463 2 P05067 1 +Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019] 0.9832721338229296 2.653654598125777 0.0079625286113813 0.999999976813208 0.0221360308677972 2 P06865 1 +Glycoside hydrolase family 20, catalytic domain [IPR015883] 0.9832721338229296 2.653654598125777 0.0079625286113813 0.999999976813208 0.0221360308677972 2 P06865 1 +Immunoglobulin V-set domain [IPR013106] 0.9441044471644237 2.4922127837904045 0.012694995834515 0.9999999999993712 0.0318427643870297 2 Q9Y624 1 +N-acetylgalactosaminyltransferase [IPR045885] 0.9273765809873532 2.422420260872322 0.0154175089334804 0.9999999999999986 0.0369168569978109 2 Q10472 1 +NECAP, PHear domain [IPR012466] 0.8788249694002475 2.2170255462201496 0.0266213458841453 1.0 0.0562347162336556 2 Q8NC96 1 +CRIB domain [IPR000095] 0.840065279477764 2.0501260398653645 0.0403521329213796 1.0 0.0783872264082277 2 Q13177 1 +p21 activated kinase binding domain [IPR033923] 0.840065279477764 2.0501260398653645 0.0403521329213796 1.0 0.0783872264082277 2 Q13177 1 +Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547] 0.8392492860057148 2.0465855495462457 0.040698794868879 1.0 0.0787969352406523 2 O15460 1 +Extended PHD (ePHD) domain [IPR034732] 0.8359853121175067 2.0324128454753283 0.0421118787536332 1.0 0.0807167410388493 2 Q03164 1 +Immunoglobulin-like domain [IPR007110] 0.7712142573189515 1.9322097077245015 0.0533336274731239 1.0 0.0970061443226639 9 P10321,Q92692,Q9Y624,P35613 4 +EB1, C-terminal [IPR004953] 0.7992656058751539 1.8718288634275304 0.061230283699428 1.0 0.1081489107269416 2 Q15555 1 +Marvel domain [IPR008253] 0.7988576091391328 1.8700333290717568 0.0614791897075144 1.0 0.1084143850575976 2 O43760 1 +Translation initiation factor IF2/IF5 domain [IPR002735] 0.7968176254590006 1.8610521262452229 0.062736815896746 1.0 0.1101538190597238 2 P55010 1 +Nucleotidyl transferase domain [IPR005835] 0.7894736842105292 1.8286717930781693 0.0674487904836589 1.0 0.116751198599032 2 Q9NR50 1 +Ricin B, lectin domain [IPR000772] 0.8781373915728726 1.7853706244291705 0.0742012202018349 1.0 0.1254177426778132 3 Q10472 1 +Histone deacetylase domain [IPR023801] 0.7768257853937219 1.7727359328011207 0.0762724739474052 1.0 0.128130764102631 2 Q13547 1 +CTP synthase GATase domain [IPR033828] 0.7690738474092269 1.738351998523162 0.0821488092275206 1.0 0.135416215510733 2 Q9NRF8 1 +CTP synthase, N-terminal [IPR017456] 0.7690738474092269 1.738351998523162 0.0821488092275206 1.0 0.135416215510733 2 Q9NRF8 1 +HR1 rho-binding domain [IPR011072] 0.7613219094247227 1.703896231921929 0.0884004751073499 1.0 0.1414793629993176 2 O75116 1 +Sterile alpha motif domain [IPR001660] 0.8525146093821727 1.6827709157853008 0.0924194473622765 1.0 0.1467367254510081 4 Q15375 1 +Plasma membrane calcium transporting P-type ATPase, C-terminal [IPR022141] 0.7552019583843375 1.6766463556083295 0.0936116563632827 1.0 0.1481769388628863 2 P20020 1 +K Homology domain [IPR004087] 0.5732013673042776 1.6269354376676126 0.1037508105646387 1.0 0.1604416543119835 22 O75179,Q06787,Q8IWZ3,Q9NRX1,Q96PU8 5 +L27 domain [IPR004172] 0.7372501019991827 1.5964925149998066 0.1103788755717178 1.0 0.1689573337469563 2 Q9NZW5 1 +L27 domain, C-terminal [IPR014775] 0.7372501019991827 1.5964925149998066 0.1103788755717178 1.0 0.1689573337469563 2 Q9NZW5 1 +MHC class I, alpha chain, C-terminal [IPR010579] 0.8285714285714267 1.592957716481764 0.1111696770287329 1.0 0.1691004127632818 3 P10321,P01889 2 +MHC class I-like antigen recognition-like [IPR011161] 0.8285714285714267 1.592957716481764 0.1111696770287329 1.0 0.1691004127632818 3 P10321,P01889 2 +MHC class I alpha chain, alpha1 alpha2 domains [IPR001039] 0.8285714285714267 1.592957716481764 0.1111696770287329 1.0 0.1691004127632818 3 P10321,P01889 2 +Immunoglobulin C1-set [IPR003597] 0.8285714285714267 1.592957716481764 0.1111696770287329 1.0 0.1691004127632818 3 P10321,P01889 2 +CAP Gly-rich domain [IPR000938] 0.7364341085271374 1.5928420332034747 0.1111956329493886 1.0 0.1691004127632818 2 Q14203 1 +Importin-beta, N-terminal domain [IPR001494] 0.6520066411756222 1.5519005344201349 0.1206860250339256 1.0 0.180139624240487 12 Q8TEX9,P55060,O00410,Q9UI26,O95373 5 +ERAP1-like C-terminal domain [IPR024571] 0.8145608058963384 1.5375923161687246 0.1241483273877324 1.0 0.183469201562919 4 Q9UIQ6 1 +CARG-binding factor, N-terminal [IPR012956] 0.7176662586699292 1.508738437532887 0.1313656386214399 1.0 0.1925820262190309 2 Q99729 1 +Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862] 0.8036734693877534 1.4955716688579106 0.1347653106068309 1.0 0.1959910418996831 3 P13674,O15460 2 +PTB/PI domain [IPR006020] 0.71154630762954 1.481263334518242 0.1385364148966537 1.0 0.1996340605227663 2 O60343 1 +Translation initiation factor IF- 2, domain 3 [IPR023115] 0.7070583435332558 1.4611027774659884 0.1439872381238318 1.0 0.2053358862738691 2 P46199 1 +K Homology domain, type 1 [IPR004088] 0.5491983544206951 1.4523186505679708 0.1464130239735108 1.0 0.2078516718642675 21 O75179,Q06787,Q8IWZ3,P51114,Q92667,Q96PU8 6 +Fragile X-related 1 protein, C-terminal region 1 [IPR032172] 0.7029783761729971 1.442767468539699 0.1490859861202378 1.0 0.2101538996656429 2 P51114 1 +Immunoglobulin subtype [IPR003599] 0.7831682737407094 1.4316693704502494 0.152238466211483 1.0 0.2135976299706964 6 Q9Y624,P35613 2 +Zinc finger, CXXC-type [IPR002857] 0.7848960384343056 1.4219074240013807 0.1550531277133973 1.0 0.2158408392276924 3 Q9Y2K7 1 +Peptidase M20, dimerisation domain [IPR011650] 0.6972664218686242 1.4170882628559722 0.1564571236935608 1.0 0.2176056776119685 2 Q96KP4 1 +Ubiquitin-associated domain [IPR015940] 0.6414702265839048 1.3823076273044914 0.1668772650386731 1.0 0.2266053220170286 9 Q13501,Q9Y5A7,Q7Z6Z7 3 +Ancestral coatomer element 1, Sec16/Sec31 [IPR024298] 0.6895144838841326 1.3822251798684702 0.1669025709848157 1.0 0.2266053220170286 2 O94979 1 +Chromo shadow domain [IPR008251] 0.7681632653061208 1.3561700717575036 0.1750450620131087 1.0 0.2340061177226351 3 Q13185,P83916 2 +Chromo domain subgroup [IPR017984] 0.7681632653061208 1.3561700717575036 0.1750450620131087 1.0 0.2340061177226351 3 Q13185,P83916 2 +Aminopeptidase N-like , N-terminal domain [IPR045357] 0.7622076817904524 1.353212158742935 0.1759878620205497 1.0 0.2348284639461097 6 Q9UIQ6 1 +Peptidase M1, membrane alanine aminopeptidase [IPR014782] 0.7622076817904524 1.353212158742935 0.1759878620205497 1.0 0.2348284639461097 6 Q9UIQ6 1 +DnaJ domain [IPR001623] 0.5892283177580224 1.346776535229231 0.1780522141300569 1.0 0.2371513136717111 14 Q99615,Q96KC8,Q8IXB1,Q99543,O60884,Q13217,P25685,Q8WXX5 8 +Exportin-2, central domain [IPR013713] 0.7575510204081612 1.3144598117164443 0.1886915138409608 1.0 0.2458131747252801 3 O95373,P55060 2 +Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245] 0.7453494564234897 1.2899885949931245 0.197054617998267 1.0 0.2536260203546486 6 Q15375 1 +Immunoglobulin subtype 2 [IPR003598] 0.7410996202094624 1.2815908824686282 0.1999862002385013 1.0 0.2562760223336039 5 Q9Y624 1 +Peptidase C2, calpain, catalytic domain [IPR001300] 0.6658506731946174 1.2758021665712502 0.202025461510567 1.0 0.2576879291541397 2 P17655 1 +Peptidase C2, calpain, large subunit, domain III [IPR022682] 0.6658506731946174 1.2758021665712502 0.202025461510567 1.0 0.2576879291541397 2 P17655 1 +Peptidase C2, calpain, domain III [IPR022683] 0.6658506731946174 1.2758021665712502 0.202025461510567 1.0 0.2576879291541397 2 P17655 1 +Calpain subdomain III [IPR033883] 0.6658506731946174 1.2758021665712502 0.202025461510567 1.0 0.2576879291541397 2 P17655 1 +Ubiquitin-conjugating enzyme E2 [IPR000608] 0.656155554685532 1.2711692742368992 0.2036684348804187 1.0 0.259182227026644 8 P49427 1 +BTB/POZ domain [IPR000210] 0.7365344281790506 1.2641301018523523 0.2061833338682568 1.0 0.2619278747407838 5 Q08380 1 +ZU5 domain [IPR000906] 0.6621787025703805 1.259301323136777 0.2079215155122877 1.0 0.2639834945794 2 Q07157 1 +Dynamin-type guanine nucleotide-binding (G) domain [IPR030381] 0.7365791464088192 1.2570739704243368 0.2087268516280778 1.0 0.2647003152999672 6 Q8IWA4,Q9H4M9 2 +Dynamin, N-terminal [IPR045063] 0.7365791464088192 1.2570739704243368 0.2087268516280778 1.0 0.2647003152999672 6 Q8IWA4,Q9H4M9 2 +SET domain [IPR001214] 0.7414884660915582 1.2513445578518736 0.2108087954760298 1.0 0.2670325698455009 3 Q9H7B4 1 +Guanylate kinase/L-type calcium channel beta subunit [IPR008145] 0.7378521845651296 1.2417744989291148 0.2143197740501579 1.0 0.2711675392038534 4 Q07157,Q9NZW5,Q9UDY2 3 +Guanylate kinase-like domain [IPR008144] 0.7378521845651296 1.2417744989291148 0.2143197740501579 1.0 0.2711675392038534 4 Q07157,Q9NZW5,Q9UDY2 3 +Fragile X-related 1 protein, C-terminal core [IPR022034] 0.7262478546829623 1.1915312471215571 0.2334450973860358 1.0 0.2928384307768926 3 Q06787 1 +Agenet-like domain [IPR008395] 0.7262478546829623 1.1915312471215571 0.2334450973860358 1.0 0.2928384307768926 3 Q06787 1 +Synaptic functional regulator FMRP, KH0 domain [IPR040472] 0.7262478546829623 1.1915312471215571 0.2334450973860358 1.0 0.2928384307768926 3 Q06787 1 +Fxr1, tudor domain [IPR041560] 0.7262478546829623 1.1915312471215571 0.2334450973860358 1.0 0.2928384307768926 3 Q06787 1 +AP complex, mu/sigma subunit [IPR022775] 0.7068361949470747 1.1506131637681705 0.2498914149918216 1.0 0.3125774866706574 5 Q92572,Q96CW1,P48444 3 +26S proteasome regulatory subunit Rpn7, N-terminal [IPR045135] 0.6372909016727886 1.1477116868403554 0.2510876050001416 1.0 0.3138951923793697 2 Q13098 1 +FAD/NAD(P)-binding domain [IPR023753] 0.7033027255521554 1.1086125606403148 0.2675973571752468 1.0 0.3330201405933037 4 O95831 1 +BRO1 domain [IPR004328] 0.6283149734802145 1.1076283156787967 0.2680223694348038 1.0 0.3333604018026774 2 Q5VW32 1 +Glycosyltransferase 2-like [IPR001173] 0.6947557782980485 1.068448204448836 0.2853183826620724 1.0 0.3538720380563436 3 Q10472 1 +Myosin tail [IPR002928] 0.692610147517002 1.0600998173807 0.289099190884388 1.0 0.3579555860105683 3 P35579 1 +Cytochrome b5-like heme/steroid binding domain [IPR001199] 0.6400098054735706 1.0444816946986426 0.2962625840229429 1.0 0.3647712330719213 7 Q8WUJ1 1 +Fumarate lyase, N-terminal [IPR022761] 0.6128110975112225 1.0386982243072451 0.298945107265685 1.0 0.3676623550767569 2 P07954 1 +Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038] 0.6119951040391707 1.035083071896298 0.3006301174293593 1.0 0.3693215800151738 2 P29692 1 +Elongation factor 1 beta central acidic region, eukaryote [IPR018940] 0.6119951040391707 1.035083071896298 0.3006301174293593 1.0 0.3693215800151738 2 P29692 1 +FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179] 0.5485843872358458 0.9788585767252046 0.3276498619683439 1.0 0.3987827145693531 9 O00170,Q9NWM8 2 +SNF2, N-terminal [IPR000330] 0.541449038276413 0.948014674591644 0.3431219836609385 1.0 0.4166345897683068 9 Q2NKX8,Q9H4L7,Q14527 3 +Zinc finger, LIM-type [IPR001781] 0.5713146092126131 0.9213706401207872 0.3568569518853417 1.0 0.4302239239012426 8 Q16527,Q9UHB6 2 +EF-hand domain [IPR002048] 0.4193606024648769 0.9124786421232484 0.361516807645311 1.0 0.4351261412216962 37 Q02818,Q9Y680,P80303,Q9BRK5,Q9NWM8,Q14257,O43852 7 +Plectin/S10, N-terminal [IPR005326] 0.5826193390452918 0.9060636969847676 0.3649021389177556 1.0 0.4382412908138419 2 P46783 1 +Septin-type guanine nucleotide-binding (G) domain [IPR030379] 0.651020408163262 0.8998042487799076 0.3682244328944235 1.0 0.4415079214475667 3 Q16181,Q15019 2 +Tubulin/FtsZ, 2-layer sandwich domain [IPR018316] 0.6472842267532041 0.8953518470013279 0.3705990328579616 1.0 0.4438710638641925 4 Q9BUF5,P68371 2 +Tubulin/FtsZ, GTPase domain [IPR003008] 0.6472842267532041 0.8953518470013279 0.3705990328579616 1.0 0.4438710638641925 4 Q9BUF5,P68371 2 +RING-type zinc-finger, LisH dimerisation motif [IPR027370] 0.6472977915594131 0.8856370580197453 0.3758131355460381 1.0 0.4496262704383775 3 Q9Y508 1 +P-type ATPase, haloacid dehalogenase domain [IPR044492] 0.6338890394308648 0.8748449833693627 0.3816582575236689 1.0 0.4553806339091415 5 P20020,Q9HD20 2 +EF-hand, Ca insensitive [IPR014837] 0.6412971774683411 0.8628790116039672 0.3882039914942501 1.0 0.4621876433653795 3 O43707 1 +cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117] 0.5675234598123262 0.8408496680166104 0.4004321582060826 1.0 0.4752025450054914 2 P10644 1 +PWI domain [IPR002483] 0.621291969745555 0.8281602742007513 0.4075797382852819 1.0 0.4818644325211478 5 Q9P2N5,Q5T8P6,O43395 3 +Thioredoxin domain [IPR013766] 0.4404424201400136 0.8226096817750546 0.4107299911454074 1.0 0.4853279153835308 21 Q8IXB1,O95881,Q6ZRP7,O14530 4 +CS domain [IPR007052] 0.5465573143147497 0.8208819243956244 0.4117135279494284 1.0 0.4862288120090188 8 Q15185,Q8WVJ2,Q96RS6 3 +PurM-like, C-terminal domain [IPR010918] 0.6233222713705466 0.7953591885191128 0.4264045927390221 1.0 0.5011564401032119 3 P49903 1 +Tudor domain [IPR002999] 0.5686032901984962 0.7685397297738854 0.4421665965303258 1.0 0.5174690504365016 7 Q92667,Q14739 2 +Threonyl/alanyl tRNA synthetase, SAD [IPR012947] 0.601263191364671 0.7548541821349408 0.4503364796596882 1.0 0.5261901800061927 5 Q9BW92 1 +14-3-3 domain [IPR023410] 0.599906925792536 0.7512313710685726 0.4525134234476908 1.0 0.5284530101760341 6 P27348 1 +Chromo domain [IPR023780] 0.6063308504794236 0.7438477424853642 0.456968593121787 1.0 0.5330896213659468 4 Q13185,P83916 2 +Endonuclease/exonuclease/phosphatase [IPR005135] 0.6046428436030928 0.7377228130516789 0.4606829062272013 1.0 0.536853052884799 4 Q9ULM6 1 +tRNA-binding domain [IPR002547] 0.5373317013463953 0.7135491400957221 0.4755060166918408 1.0 0.5526626483643541 2 Q12904 1 +Ran binding domain [IPR000156] 0.5928084681487696 0.6951062619995125 0.486988710724535 1.0 0.5651124933420857 4 P43487 1 +Target SNARE coiled-coil homology domain [IPR000727] 0.5874558533233909 0.6760302239601628 0.4990214558992214 1.0 0.5775516744854673 4 Q86Y82 1 +Glutaredoxin, PICOT-like [IPR033658] 0.522235822113424 0.6518932728205554 0.5144700249499663 1.0 0.5929347929061719 2 Q86SX6 1 +TOG domain [IPR034085] 0.5325322677602449 0.6345247207660423 0.525738438934056 1.0 0.6040223757659297 7 Q8TEX9,O75122,Q7Z460,O00410 4 +PDZ domain [IPR001478] 0.442637615710224 0.6130989630753804 0.5398109058120797 1.0 0.6185743522046708 13 Q6ZWJ1,Q07157,Q9NZW5,Q9UDY2,Q96HC4,O43464 6 +GOLD domain [IPR009038] 0.5682442685134996 0.6087158408059344 0.542712805351276 1.0 0.6215757598788832 4 Q9BVK6,Q9H3P7 2 +Ribosomal protein S7 domain [IPR023798] 0.4985720114239117 0.5586668312686626 0.5763891201219409 1.0 0.6550282558905157 2 P46782 1 +Helicase/UvrB, N-terminal [IPR006935] 0.496940024479811 0.5524130162884487 0.5806654147418342 1.0 0.6595471317238086 2 P19447 1 +Translational (tr)-type GTP-binding domain [IPR000795] 0.4357781007219316 0.5449431371272776 0.5857926266761453 1.0 0.6639989618870328 11 Q05639,O00178,P46199,O60841,Q7Z2Z2,P49411 6 +OBG-type guanine nucleotide-binding (G) domain [IPR031167] 0.5322211742547527 0.5150536356561868 0.6065155404183322 1.0 0.6818648636911618 5 P55039,A4D1E9 2 +TGS [IPR004095] 0.5280237776655407 0.5051640478422367 0.6134436194938293 1.0 0.6885975085589233 6 Q9BW92,P55039 2 +Cation-transporting P-type ATPase, C-terminal [IPR006068] 0.5308697480809376 0.484023299488093 0.6283693336739853 1.0 0.7039145006363188 4 P20020 1 +Cation-transporting P-type ATPase, N-terminal [IPR004014] 0.5308697480809376 0.484023299488093 0.6283693336739853 1.0 0.7039145006363188 4 P20020 1 +Ribosomal L28e/Mak16 [IPR029004] 0.4769481844145331 0.4779099800759948 0.6327142777904389 1.0 0.7069810451530362 2 P46779 1 +Translation elongation factor EFTu/EF1A, C-terminal [IPR004160] 0.523009702228974 0.4590569424039475 0.6461932756754143 1.0 0.7202123736493846 4 Q05639,P49411 2 +THIF-type NAD/FAD binding fold [IPR000594] 0.5071268664843234 0.4350045223410287 0.6635591448736249 1.0 0.7338764383653403 5 Q8TBC4 1 +B-box, C-terminal [IPR003649] 0.5175510204081585 0.430377536132148 0.6669210334362379 1.0 0.7369644987569283 3 Q13263,Q9UPN9 2 +Serine-tRNA ligase catalytic core domain [IPR033729] 0.461036311709507 0.4216990392003851 0.6732447058444033 1.0 0.7434334551080896 2 Q9NP81 1 +Alanyl-tRNA synthetase, class IIc, N-terminal [IPR018164] 0.4606283149734817 0.420297181290826 0.6742683687827462 1.0 0.7434334551080896 2 Q5JTZ9 1 +Death domain [IPR000488] 0.5121798214467764 0.4139818246669011 0.6788874176866697 1.0 0.7464367157464933 3 Q13546 1 +Chaperone DnaJ, C-terminal [IPR002939] 0.5057341256468096 0.4059744990255836 0.684761337644068 1.0 0.750643161255885 4 O60884,P25685 2 +Arf GTPase activating protein [IPR001164] 0.455732354141166 0.40363663408966 0.6864799424045962 1.0 0.7521521640995052 2 Q8N6T3 1 +Zinc finger, RanBP2-type [IPR001876] 0.3969663249212936 0.3664837289251629 0.7140041518043803 1.0 0.7765059989207875 9 P35637,Q92804 2 +Survival motor neuron [IPR010304] 0.4345165238678111 0.3350981721278865 0.7375510316628928 1.0 0.7965985847871814 2 Q16637 1 +SAB domain [IPR007477] 0.4320685434516521 0.3275950077039094 0.7432178971039007 1.0 0.7999687497461957 2 P11171 1 +Band 4.1, C-terminal [IPR008379] 0.4320685434516521 0.3275950077039094 0.7432178971039007 1.0 0.7999687497461957 2 P11171 1 +FERM adjacent (FA) [IPR014847] 0.4320685434516521 0.3275950077039094 0.7432178971039007 1.0 0.7999687497461957 2 P11171 1 +PPM-type phosphatase domain [IPR001932] 0.431660546715627 0.3263530009694156 0.7441572923142696 1.0 0.8005880067510172 2 Q9H0C8 1 +DALR anticodon binding [IPR008909] 0.4275805793553642 0.3140684388343496 0.7534690597378884 1.0 0.808517918856774 2 Q5T160 1 +Arginyl-tRNA synthetase, catalytic core domain [IPR035684] 0.4275805793553642 0.3140684388343496 0.7534690597378884 1.0 0.808517918856774 2 Q5T160 1 +WHEP-TRS domain [IPR000738] 0.4630461412821558 0.2870286914442487 0.7740903515276956 1.0 0.8259217287770028 4 P07814,P41250,P23381 3 +Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal [IPR015211] 0.4145246838025315 0.2764610776086914 0.7821939506516264 1.0 0.8320516634552689 2 P09960 1 +Oxoglutarate/iron-dependent dioxygenase [IPR005123] 0.4156751780861533 0.2583165921038716 0.796162582055751 1.0 0.8443036949027674 7 O60568,P13674,O15460 3 +Prolyl 4-hydroxylase, alpha subunit [IPR006620] 0.4156751780861533 0.2583165921038716 0.796162582055751 1.0 0.8443036949027674 7 O60568,P13674,O15460 3 +Mu homology domain [IPR028565] 0.4495343346819461 0.253517007836491 0.7998687200010806 1.0 0.846128736337411 4 P48444 1 +UBX domain [IPR001012] 0.4374685123427118 0.2178699587861861 0.827530434305634 1.0 0.8706887201139182 3 Q96CS3 1 +Glutamine amidotransferase type 2 domain [IPR017932] 0.4310204081632593 0.204115705475103 0.838263081503783 1.0 0.8802963305763223 3 P08243,Q06210 2 +Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120] 0.3827009383924898 0.1963932395276021 0.8443023873037219 1.0 0.8849480217735388 2 O00154 1 +Aminotransferase, class I/classII [IPR004839] 0.4126226213339603 0.1871368820652458 0.8515533112240916 1.0 0.8897731757265737 5 O15269 1 +CLASP N-terminal domain [IPR024395] 0.4187755102040755 0.1795187538377101 0.857530393087448 1.0 0.8937011063503784 3 O75122,Q7Z460 2 +Valyl tRNA synthetase, anticodon-binding domain [IPR033705] 0.3663810689514462 0.1620710881954683 0.8712498734387328 1.0 0.9061232054856384 2 Q5ST30 1 +OCRE domain [IPR041591] 0.3639330885352908 0.157325819449579 0.874988072657388 1.0 0.9080220725689458 2 P98175 1 +Importin-alpha, importin-beta-binding domain [IPR002652] 0.401388321763988 0.1525888666672217 0.8787225052914058 1.0 0.9101387150089044 4 P52294,O00629,P52292 3 +Translation elongation factor EFTu-like, domain 2 [IPR004161] 0.3431492842535705 0.1412854632894057 0.8876444330324293 1.0 0.917266831613327 8 Q05639,Q9Y450,Q15029,O60841,P15170,P49411,Q96RP9 7 +DNA mismatch repair protein MutS-like, N-terminal [IPR007695] 0.3963265306122401 0.1396936362429354 0.8889020546466575 1.0 0.917266831613327 3 P52701,P20585 2 +DNA mismatch repair protein MutS, C-terminal [IPR000432] 0.3963265306122401 0.1396936362429354 0.8889020546466575 1.0 0.917266831613327 3 P52701,P20585 2 +DNA mismatch repair protein MutS, core [IPR007696] 0.3963265306122401 0.1396936362429354 0.8889020546466575 1.0 0.917266831613327 3 P52701,P20585 2 +DNA mismatch repair protein MutS, connector domain [IPR007860] 0.3963265306122401 0.1396936362429354 0.8889020546466575 1.0 0.917266831613327 3 P52701,P20585 2 +RuvB-like, AAA-lid domain [IPR041048] 0.348837209302327 0.1303831672776691 0.8962632834708288 1.0 0.9226980151462324 2 Q9Y230 1 +TIP49, P-loop domain [IPR010339] 0.348837209302327 0.1303831672776691 0.8962632834708288 1.0 0.9226980151462324 2 Q9Y230 1 +Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) [IPR002314] 0.3759705762157833 0.120369817184963 0.9041901999279008 1.0 0.92955317888801 6 P41250,P49591,Q9BW92,P07814,Q9NP81 5 +Glutamine amidotransferase [IPR017926] 0.3791762561826611 0.1163061733204406 0.9074098932165768 1.0 0.9315566550808836 4 Q9NRF8 1 +AARP2CN [IPR012948] 0.3243574051407527 0.0949920141759833 0.9243211700019444 1.0 0.9449475838374132 2 Q2NL82 1 +Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034] 0.3243574051407527 0.0949920141759833 0.9243211700019444 1.0 0.9449475838374132 2 Q2NL82 1 +Bms1/Tsr1-type G domain [IPR030387] 0.3243574051407527 0.0949920141759833 0.9243211700019444 1.0 0.9449475838374132 2 Q2NL82 1 +G-patch domain [IPR000467] 0.3148798147279145 0.0862583792212994 0.931261023679974 1.0 0.9498344114435358 8 Q8N1G2,Q5T3I0 2 +LEM domain [IPR003887] 0.3521255113482222 0.0856176263036397 0.9317703861469366 1.0 0.9499133422054304 5 Q9Y2U8 1 +WW domain [IPR001202] 0.296891560350471 0.0842457272603345 0.9328610622888835 1.0 0.9505845579116102 10 Q6ZWJ1,O60828,Q8N1G2 3 +Peptidase M24 [IPR000994] 0.3488562091503286 0.0815041853445041 0.935040996531197 1.0 0.9523645907235304 5 P12955,P50579,Q9NQW7,Q9Y5B9 4 +Zinc finger, RING-type [IPR001841] 0.2953572357001605 0.0773908942551041 0.938312584390075 1.0 0.955254339386007 18 Q12899,Q14527 2 +Histidine kinase/HSP90-like ATPase [IPR003594] 0.3258313273861565 0.0740534485585268 0.9409678561711144 1.0 0.9570713763738578 7 Q02880 1 +Zinc finger, UBR-type [IPR003126] 0.3408163265306079 0.0700319066952302 0.9441682641032244 1.0 0.9598825764045265 3 Q8N806,Q5T4S7 2 +Thioesterase domain [IPR006683] 0.2962056303549502 0.0660271981885322 0.9473561716742565 1.0 0.9611663712097004 2 O00154 1 +NAD-dependent epimerase/dehydratase [IPR001509] 0.326530612244893 0.0582206368115545 0.9535728828037175 1.0 0.9658713815225126 3 Q13630,Q9NRG7 2 +GTP binding domain [IPR006073] 0.2726855466941734 0.0330703866300398 0.9736184578734012 1.0 0.9848146222923684 11 P55039,P36915,A4D1E9 3 +Phosphoribosyltransferase domain [IPR000836] 0.2691993464052309 0.0191046556726116 0.9847576174191291 1.0 0.9947092332129835 5 Q06203,P07741,P00492,O60256 4 +BRCT domain [IPR001357] 0.2507685372183964 0.0180967822711993 0.985561644907876 1.0 0.9950643053959686 9 P38398 1 diff --git a/interpro_domain/selections.json b/interpro_domain/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..873f6ccc761095ab2ff24e0810db7214f838c026 --- /dev/null +++ b/interpro_domain/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1-acyl-sn-glycerol-3-phosphate acyltransferase [IPR004552]", "116kDa U5 small nuclear ribonucleoprotein component, C-terminal [IPR035655]", "116kDa U5 small nuclear ribonucleoprotein component, N-terminal [IPR031950]", "14-3-3 domain [IPR023410]", "18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23, C-terminal [IPR022238]", "2-oxoacid dehydrogenase acyltransferase, catalytic domain [IPR001078]", "2-oxoglutarate dehydrogenase E1 component, N-terminal domain [IPR032106]", "26S proteasome non-ATPase regulatory subunit RPN1, C-terminal [IPR041433]", "26S proteasome regulatory subunit RPN2, C-terminal [IPR040623]", "26S proteasome regulatory subunit RPN5, C-terminal domain [IPR040896]", "26S proteasome regulatory subunit Rpn6, N-terminal [IPR040773]", "26S proteasome regulatory subunit Rpn7, N-terminal [IPR045135]", "26S proteasome regulatory subunit, C-terminal [IPR013586]", "2Fe-2S ferredoxin-type iron-sulfur binding domain [IPR001041]", "3'-5' exonuclease domain [IPR002562]", "3-beta hydroxysteroid dehydrogenase/isomerase [IPR002225]", "3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108]", "3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176]", "3-hydroxyisobutyrate dehydrogenase, NAD-binding domain [IPR029154]", "3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal [IPR001104]", "4'-phosphopantetheinyl transferase domain [IPR008278]", "40S ribosomal protein S11, N-terminal [IPR032440]", "40S ribosomal protein S4, C-terminal domain [IPR032277]", "40S ribosomal protein SA, C-terminal domain [IPR032281]", "4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]", "6-phosphogluconate dehydrogenase, C-terminal [IPR006114]", "6-phosphogluconate dehydrogenase, NADP-binding [IPR006115]", "6-phosphogluconolactonase, DevB-type [IPR005900]", "60S ribosomal protein L10P, insertion domain [IPR040637]", "60S ribosomal protein L4, C-terminal domain [IPR025755]", "6S proteasome subunit Rpn6, C-terminal helix domain [IPR040780]", "A kinase-anchoring protein AKAP5 and AKAP12, calmodulin (CaM)-binding motif [IPR001573]", "AAA ATPase, AAA+ lid domain [IPR041569]", "AAA+ ATPase domain [IPR003593]", "AARP2CN [IPR012948]", "AATF leucine zipper-containing domain [IPR025160]", "ABC transporter type 1, transmembrane domain [IPR011527]", "ABC transporter-like, ATP-binding domain [IPR003439]", "ABC-transporter extension domain [IPR032781]", "ADAM10/ADAM17 catalytic domain [IPR034025]", "ADAM17, membrane-proximal domain [IPR032029]", "ADAR1, first double-stranded RNA binding domain [IPR044456]", "ADAR1, third double-stranded RNA binding domain [IPR044457]", "ADNP, zinc finger domain [IPR045762]", "AGC-kinase, C-terminal [IPR000961]", "AIMP2, lysyl-tRNA synthetase binding domain [IPR031889]", "AIMP2, thioredoxin-like domain [IPR041503]", "ALIX V-shaped domain [IPR025304]", "AMP-binding enzyme, C-terminal domain [IPR025110]", "AMP-dependent synthetase/ligase [IPR000873]", "AP complex, mu/sigma subunit [IPR022775]", "AP-2 complex subunit mu, N-terminal [IPR043532]", "AP-3 complex subunit beta 1, serine-rich domain [IPR029394]", "AP-3 complex subunit beta, C-terminal domain [IPR029390]", "AP-3 complex subunit delta domain, metazoa [IPR010474]", "AP180 N-terminal homology (ANTH) domain [IPR011417]", "APC10/DOC domain [IPR004939]", "ARHGEF1-like, PH domain [IPR041020]", "ARHGEF2, PH domain [IPR037806]", "ARID DNA-binding domain [IPR001606]", "ATP synthase, F1 complex, alpha subunit nucleotide-binding domain [IPR033732]", "ATP synthase, alpha subunit, C-terminal [IPR000793]", "ATP-citrate lyase/succinyl-CoA ligase [IPR005811]", "ATP-citrate synthase, citrate-binding domain [IPR032263]", "ATP-cone domain [IPR005144]", "ATP-dependent DNA helicase RecQ, zinc-binding domain [IPR032284]", "ATP-dependent RNA helicase Ski2, C-terminal [IPR012961]", "ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain [IPR044728]", "ATP-dependent helicase, C-terminal [IPR006555]", "ATP-grasp fold [IPR011761]", "ATP-grasp fold, succinyl-CoA synthetase-type [IPR013650]", "ATP-sulfurylase PUA-like domain [IPR025980]", "ATP:guanido phosphotransferase, N-terminal [IPR022413]", "ATP:guanido phosphotransferase, catalytic domain [IPR022414]", "ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]", "ATPase, AAA-type, core [IPR003959]", "ATPase, BadF/BadG/BcrA/BcrD type [IPR002731]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain [IPR004100]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain [IPR000194]", "ATPase, V1 complex, subunit H, C-terminal [IPR011987]", "ATPase, dynein-related, AAA domain [IPR011704]", "ATPsynthase alpha/beta subunit, N-terminal extension [IPR031686]", "AWS domain [IPR006560]", "Acetyl-CoA carboxylase [IPR034733]", "Acetyl-CoA carboxylase, central domain [IPR013537]", "Acetyl-coA carboxylase zinc finger domain [IPR041010]", "Acetyl-coenzyme A carboxyltransferase, C-terminal [IPR011763]", "Acetyl-coenzyme A carboxyltransferase, N-terminal [IPR011762]", "Acid ceramidase, N-terminal [IPR029130]", "Acinus, RNA recognition motif [IPR034257]", "Aconitase A, swivel domain [IPR044137]", "Aconitase A/isopropylmalate dehydratase small subunit, swivel domain [IPR000573]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain [IPR001030]", "Actin-depolymerising factor homology domain [IPR002108]", "Activator of Hsp90 ATPase, N-terminal [IPR015310]", "Acyl transferase [IPR014043]", "Acyl-CoA dehydrogenase/oxidase C-terminal [IPR009075]", "Acyl-CoA dehydrogenase/oxidase, N-terminal [IPR013786]", "Acyl-CoA oxidase, C-terminal [IPR002655]", "Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091]", "Acyl-CoA-binding protein, ACBP [IPR000582]", "Acyl-coenzyme A oxidase, N-terminal [IPR029320]", "Acylamino-acid-releasing enzyme, N-terminal domain [IPR045550]", "Acylglycerol kinase, C-terminal [IPR045579]", "Adenosine deaminase/editase [IPR002466]", "Adenylate cyclase-associated CAP, C-terminal [IPR013912]", "Adenylate cyclase-associated CAP, N-terminal [IPR013992]", "Adenylate kinase, active site lid domain [IPR007862]", "Adenylosuccinate lyase C-terminal [IPR019468]", "Afadin, cargo binding domain [IPR037977]", "Agenet-like domain [IPR008395]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal [IPR007886]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain [IPR007698]", "Alanyl-tRNA synthetase, class IIc, N-terminal [IPR018164]", "Alanyl-tRNA synthetase, class IIc, core domain [IPR018165]", "Alcohol dehydrogenase, N-terminal [IPR013154]", "Alcohol dehydrogenase-like, C-terminal [IPR013149]", "Aldehyde dehydrogenase domain [IPR015590]", "Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant [IPR000866]", "Alpha Spectrin, SH3 domain [IPR035825]", "Alpha crystallin/Hsp20 domain [IPR002068]", "Alpha galactosidase A, C-terminal beta-sandwich domain [IPR035373]", "Alpha-2-macroglobulin RAP, C-terminal [IPR010483]", "Alpha-2-macroglobulin RAP, domain 2 [IPR038001]", "Alpha-2-macroglobulin RAP, domain 3 [IPR037999]", "Alpha-2-macroglobulin receptor-associated protein, domain 1 [IPR009066]", "Alpha-D-phosphohexomutase, C-terminal [IPR005843]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain I [IPR005844]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain II [IPR005845]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain III [IPR005846]", "Alpha-L-fucosidase, C-terminal [IPR031919]", "Alpha-N-acetylglucosaminidase, C-terminal [IPR024732]", "Alpha-N-acetylglucosaminidase, N-terminal [IPR024240]", "Alpha-N-acetylglucosaminidase, tim-barrel domain [IPR024733]", "Alpha-glycerophosphate oxidase, C-terminal [IPR031656]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like [IPR027450]", "Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal [IPR024366]", "Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain [IPR024367]", "Alpha/beta hydrolase fold-1 [IPR000073]", "Amidase signature domain [IPR023631]", "Amidohydrolase-related [IPR006680]", "Amidophosphoribosyltransferase, N-terminal [IPR035584]", "Amine oxidase [IPR002937]", "Amino acid permease, N-terminal [IPR013612]", "Amino acid permease/ SLC12A domain [IPR004841]", "Aminoacyl-tRNA synthetase, class II (D/K/N) [IPR004364]", "Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) [IPR002314]", "Aminoacyl-tRNA synthetase, class II [IPR006195]", "Aminoacyl-tRNA synthetase, class Ia [IPR002300]", "Aminomethyltransferase, folate-binding domain [IPR006222]", "Aminopeptidase N-like , N-terminal domain [IPR045357]", "Aminopeptidase P [IPR033740]", "Aminopeptidase P, N-terminal [IPR007865]", "Aminotransferase class V domain [IPR000192]", "Aminotransferase, class I/classII [IPR004839]", "Amyloidogenic glycoprotein, E2 domain [IPR024329]", "Amyloidogenic glycoprotein, amyloid-beta peptide [IPR013803]", "Amyloidogenic glycoprotein, copper-binding [IPR011178]", "Amyloidogenic glycoprotein, extracellular [IPR008154]", "Amyloidogenic glycoprotein, heparin-binding [IPR015849]", "Anaphase-promoting complex subunit 1, C-terminal [IPR041221]", "Anaphase-promoting complex subunit 4, WD40 domain [IPR024977]", "Anaphase-promoting complex subunit 5 domain [IPR026000]", "Ancestral coatomer element 1, Sec16/Sec31 [IPR024298]", "Angiomotin, C-terminal [IPR024646]", "Anillin homology domain [IPR012966]", "Anillin, N-terminal domain [IPR031970]", "Anillin, PH domain [IPR037840]", "Anion-transporting ATPase-like domain [IPR025723]", "Ankyrin repeat and LEM domain-containing protein 2, LEM domain [IPR035006]", "Ankyrin, UPA domain [IPR040745]", "Ankyrin-3, death domain [IPR037971]", "Anticodon-binding [IPR004154]", "Anticodon-binding domain [IPR019181]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal [IPR006190]", "ApaG domain [IPR007474]", "Apoptosis-antagonizing transcription factor, C-terminal [IPR012617]", "Arf GTPase activating protein [IPR001164]", "Arginyl tRNA synthetase N-terminal domain [IPR005148]", "Arginyl-tRNA synthetase, catalytic core domain [IPR035684]", "Ariadne domain [IPR045840]", "Armadillo repeat-containing domain [IPR006911]", "Aromatic amino acid beta-eliminating lyase/threonine aldolase [IPR001597]", "Asn/Gln amidotransferase [IPR018027]", "Asparagine synthase [IPR001962]", "Asparagine synthase, N-terminal domain [IPR033738]", "Aspartate/glutamate/uridylate kinase [IPR001048]", "Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain [IPR006131]", "Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding [IPR006132]", "Aspartic peptidase, DDI1-type [IPR019103]", "Aspartyl beta-hydroxylase/Triadin domain [IPR007943]", "Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic [IPR006075]", "Aspartyl/asparaginy/proline hydroxylase [IPR007803]", "Ataxin 2, SM domain [IPR025852]", "Ataxin-10 domain [IPR019156]", "Ataxin-2, C-terminal [IPR009818]", "Aurora-A binding [IPR015128]", "Autophagy-related, C-terminal [IPR015412]", "B(0)AT2, solute-binding domain [IPR042934]", "B-block binding subunit of TFIIIC [IPR007309]", "B-box, C-terminal [IPR003649]", "B-box-type zinc finger [IPR000315]", "B3/B4 tRNA-binding domain [IPR005146]", "B30.2/SPRY domain [IPR001870]", "BAP29/BAP31, transmembrane domain [IPR040463]", "BAR domain [IPR004148]", "BAT2, N-terminal [IPR009738]", "BAZ2A/BAZ2B, bromodomain [IPR037374]", "BDHCT [IPR012532]", "BEACH domain [IPR000409]", "BING4, C-terminal domain [IPR012952]", "BOP1, N-terminal domain [IPR012953]", "BP28, C-terminal domain [IPR012954]", "BRCA1, serine-rich domain [IPR025994]", "BRCT domain [IPR001357]", "BRK domain [IPR006576]", "BRO1 domain [IPR004328]", "BSD domain [IPR005607]", "BTB/Kelch-associated [IPR011705]", "BTB/POZ domain [IPR000210]", "BURAN domain [IPR045354]", "BZW1/2, W2 domain [IPR043510]", "Bacterial Ig-like, group 2 [IPR003343]", "Bacterial surface antigen (D15) [IPR000184]", "Band 4.1 domain [IPR019749]", "Band 4.1, C-terminal [IPR008379]", "Band 7 domain [IPR001107]", "Band 7, C-terminal extension [IPR032435]", "Bap31/Bap29 cytoplasmic coiled-coil domain [IPR041672]", "Beta-Casp domain [IPR022712]", "Beta-adaptin appendage, C-terminal subdomain [IPR015151]", "Beta-amyloid precursor protein C-terminal [IPR019543]", "Beta-catenin-like protein 1, N-terminal [IPR013180]", "Beta-galactosidase jelly roll domain [IPR025300]", "Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019]", "Beta-ketoacyl synthase, C-terminal [IPR014031]", "Beta-ketoacyl synthase, N-terminal [IPR014030]", "Bifunctional delta 1-pyrroline-5-carboxylate synthetase, glutamate-5-kinase domain [IPR041744]", "Biliverdin reductase, catalytic [IPR015249]", "Biotin carboxylase, C-terminal [IPR005482]", "Biotin carboxylase-like, N-terminal domain [IPR005481]", "Biotin carboxylation domain [IPR011764]", "Biotin protein ligase, C-terminal [IPR003142]", "Biotin-protein ligase, N-terminal [IPR019197]", "Biotin/lipoyl attachment [IPR000089]", "Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain [IPR004143]", "Bloom syndrome protein, BDHCT-box associated domain [IPR032439]", "Bloom syndrome protein, N-terminal domain [IPR032437]", "Bms1/Tsr1-type G domain [IPR030387]", "Borealin, N-terminal [IPR018851]", "Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal [IPR018955]", "Brdt, bromodomain, repeat I [IPR043508]", "Brdt, bromodomain, repeat II [IPR043509]", "Brix domain [IPR007109]", "Bromo adjacent homology (BAH) domain [IPR001025]", "Bromodomain [IPR001487]", "Bromodomain adjacent to zinc finger domain protein 1A, bromodomain [IPR037325]", "Brr2, N-terminal helicase PWI domain [IPR041094]", "Butyrophylin-like, SPRY domain [IPR003879]", "C-CAP/cofactor C-like domain [IPR017901]", "C-terminal associated domain of TOPRIM [IPR031660]", "C2 DOCK-type domain [IPR027007]", "C2 domain [IPR000008]", "C4-type zinc-finger of DNA polymerase delta [IPR025687]", "CAAX prenyl protease 1, N-terminal [IPR032456]", "CAP Gly-rich domain [IPR000938]", "CAPN2, penta-EF hand, calcium binding motif [IPR042736]", "CARG-binding factor, N-terminal [IPR012956]", "CARP motif [IPR006599]", "CBS domain [IPR000644]", "CCAAT-binding factor [IPR005612]", "CCD97-like, C-terminal [IPR040233]", "CCR4-NOT transcription complex subunit 1, CAF1-binding domain [IPR032191]", "CCR4-NOT transcription complex subunit 1, HEAT repeat [IPR032194]", "CCR4-NOT transcription complex subunit 1, TTP binding domain [IPR032193]", "CCR4-NOT transcription complex subunit 1, domain 4 [IPR024557]", "CCR4-NOT transcription complex subunit 6 [IPR034966]", "CCR4-Not complex component, Not N-terminal domain [IPR007207]", "CCR4-Not complex component, Not1, C-terminal [IPR007196]", "CD2-associated protein, first SH3 domain [IPR035775]", "CD2-associated protein, second SH3 domain [IPR035776]", "CD2-associated protein, third SH3 domain [IPR035777]", "CD80-like, immunoglobulin C2-set [IPR013162]", "CDC48, N-terminal subdomain [IPR003338]", "CDC48, domain 2 [IPR004201]", "CELF1/2, RNA recognition motif 1 [IPR034196]", "CELF1/2, RNA recognition motif 2 [IPR034198]", "CELF1/2, RNA recognition motif 3 [IPR034199]", "CENP-T/Histone H4, histone fold [IPR035425]", "CEP170, C-terminal [IPR029300]", "CFA20 domain [IPR007714]", "CHD subfamily II, SANT-like domain [IPR009462]", "CHD, C-terminal 2 [IPR012957]", "CHD, N-terminal [IPR012958]", "CHIP, N-terminal tetratricopeptide repeat domain [IPR041312]", "CHIP/LubX , U box domain [IPR045202]", "CHORD domain [IPR007051]", "CID domain [IPR006569]", "CIDE-N domain [IPR003508]", "CLASP N-terminal domain [IPR024395]", "CLU central domain [IPR033646]", "CLU domain [IPR025697]", "CNNM, transmembrane domain [IPR002550]", "COMM domain [IPR017920]", "COP9 signalosome complex subunit 4, helix turn helix domain [IPR041406]", "COP9 signalosome complex subunit 7, helix I [IPR041481]", "COS domain [IPR017903]", "CPH domain [IPR021097]", "CPL domain [IPR012959]", "CPSF2, metallo-hydrolase domain [IPR035639]", "CPSF7, RNA recognition motif [IPR034773]", "CRA domain [IPR013144]", "CRIB domain [IPR000095]", "CRK, C-terminal SH3 domain [IPR035458]", "CRK, N-terminal SH3 domain [IPR035457]", "CS domain [IPR007052]", "CSK-like, SH2 domain [IPR035027]", "CSN8/PSMD8/EIF3K [IPR033464]", "CTLH, C-terminal LisH motif [IPR006595]", "CTLH/CRA C-terminal to LisH motif domain [IPR024964]", "CTP synthase GATase domain [IPR033828]", "CTP synthase, N-terminal [IPR017456]", "CUB domain [IPR000859]", "CYRIA/CYRIB, Rac1 binding domain [IPR009828]", "Cadherin-like [IPR002126]", "Calcineurin-like phosphoesterase domain, ApaH type [IPR004843]", "Calcineurin-like phosphoesterase domain, lpxH-type [IPR024654]", "Calcium/calmodulin-dependent protein kinase II, association-domain [IPR013543]", "Calcyclin-binding Protein, CS domain [IPR037893]", "Calpain subdomain III [IPR033883]", "Calponin homology domain [IPR001715]", "Caprin-1 dimerization domain [IPR041637]", "Carbamoyl-phosphate synthase large subunit, CPSase domain [IPR005483]", "Carbamoyl-phosphate synthase small subunit, GATase1 domain [IPR035686]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain [IPR002474]", "Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain [IPR005479]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain [IPR005480]", "Carbohydrate kinase PfkB [IPR011611]", "Carboxylase, conserved domain [IPR003379]", "Carboxypeptidase D, carboxypeptidase-like domain 2 [IPR034224]", "Carboxypeptidase D, carboxypeptidase-like domain 3 [IPR033848]", "Cation-transporting P-type ATPase, C-terminal [IPR006068]", "Cation-transporting P-type ATPase, N-terminal [IPR004014]", "Cdc23 [IPR007192]", "Cdc37, C-terminal [IPR013873]", "Cdc37, Hsp90 binding [IPR013874]", "Cdc37, N-terminal domain [IPR013855]", "Cell division control protein 73, C-terminal [IPR031336]", "Cellular tumor antigen p53, transactivation domain 2 [IPR040926]", "Centromere protein CENP-B, C-terminal domain [IPR015115]", "Chaperone DnaJ, C-terminal [IPR002939]", "Chitinase II [IPR011583]", "Choline/carnitine acyltransferase domain [IPR039551]", "Choloylglycine hydrolase/NAAA C-terminal [IPR029132]", "Chromatin assembly factor 1 subunit B, C-terminal domain [IPR029129]", "Chromatin target of PRMT1 protein, C-terminal [IPR025715]", "Chromo domain [IPR023780]", "Chromo domain subgroup [IPR017984]", "Chromo shadow domain [IPR008251]", "Chromo/chromo shadow domain [IPR000953]", "Chromosome passenger complex (CPC) protein INCENP N-terminal [IPR022006]", "Circularly permuted (CP)-type guanine nucleotide-binding (G) domain [IPR030378]", "Class I myosin tail homology domain [IPR010926]", "Class I myosin, motor domain [IPR036072]", "Class II PurE [IPR033626]", "Class II aldolase/adducin N-terminal [IPR001303]", "Class VI myosin, motor domain [IPR036114]", "Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain [IPR003164]", "Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain [IPR008152]", "Clathrin, heavy chain, linker, core motif [IPR015348]", "Clathrin/coatomer adaptor, adaptin-like, N-terminal [IPR002553]", "Cleavage and polyadenylation specificity factor 2, C-terminal [IPR025069]", "Cleavage stimulation factor subunit 1, dimerisation domain [IPR032028]", "Cleavage stimulation factor subunit 2, hinge domain [IPR025742]", "Cleavage/polyadenylation specificity factor, A subunit, C-terminal [IPR004871]", "Cleavage/polyadenylation specificity factor, A subunit, N-terminal [IPR018846]", "Clp ATPase, C-terminal [IPR019489]", "Clustered mitochondria protein, N-terminal [IPR028275]", "Cns1/TTC4, wheel domain [IPR044059]", "CoA-binding [IPR003781]", "Coatomer beta subunit, C-terminal [IPR011710]", "Coatomer beta subunit, appendage platform domain [IPR029446]", "Coatomer subunit gamma, C-terminal [IPR032154]", "Coatomer, WD associated region [IPR006692]", "Coatomer, alpha subunit, C-terminal [IPR010714]", "Coatomer, gamma subunit, appendage, Ig-like subdomain [IPR013040]", "Cobalamin (vitamin B12)-binding domain [IPR006158]", "Cobalamin (vitamin B12)-binding module, cap domain [IPR003759]", "Cobalamin adenosyltransferase-like [IPR016030]", "Coilin, N-terminal domain [IPR031722]", "Cold shock domain [IPR011129]", "Cold-shock (CSD) domain [IPR019844]", "Cold-shock protein, DNA-binding [IPR002059]", "Complex 1 LYR protein domain [IPR008011]", "Condensin complex subunit 1, C-terminal [IPR032682]", "Condensin complex subunit 1, N-terminal [IPR024324]", "Cop9 signalosome subunit 5 C-terminal domain [IPR040961]", "Copine, C-terminal [IPR010734]", "Copine, C2B domain [IPR037768]", "Core histone macro-H2A, macro domain [IPR035796]", "Cortactin, SH3 domain [IPR035716]", "Creatinase, N-terminal [IPR000587]", "Cullin homology domain [IPR016158]", "Cullin protein, neddylation domain [IPR019559]", "Cullin, N-terminal [IPR001373]", "Cupin-like domain 8 [IPR041667]", "Cwf19-like protein, C-terminal domain-2 [IPR006767]", "Cwf19-like, C-terminal domain-1 [IPR006768]", "Cyclic nucleotide-binding domain [IPR000595]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain [IPR002130]", "Cystatin domain [IPR000010]", "Cysteine-rich flanking region, C-terminal [IPR000483]", "Cystine knot, C-terminal [IPR006207]", "Cytochrome C oxidase subunit II, transmembrane domain [IPR011759]", "Cytochrome b5-like heme/steroid binding domain [IPR001199]", "Cytochrome c oxidase assembly factor 3, mitochondrial, coiled-coil domain [IPR018628]", "Cytochrome c oxidase subunit 2, C-terminal [IPR034210]", "Cytochrome c oxidase subunit II-like C-terminal [IPR002429]", "Cytochrome c oxidase, subunit II [IPR014222]", "Cytoplasmic activation/proliferation-associated protein-1 C term [IPR022070]", "Cytoskeleton-associated protein 2, C-terminal [IPR029197]", "D-3-phosphoglycerate dehydrogenase, ASB domain [IPR045626]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain [IPR006140]", "D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain [IPR006139]", "DALR anticodon binding [IPR008909]", "DAZ-associated protein 1, RNA recognition motif 1 [IPR034134]", "DAZ-associated protein 1, RNA recognition motif 2 [IPR034131]", "DBC1/CARP1 catalytically inactive NUDIX hydrolase domain [IPR025954]", "DBINO domain [IPR020838]", "DBP10, C-terminal [IPR012541]", "DDE superfamily endonuclease domain [IPR004875]", "DDHD domain [IPR004177]", "DDT domain [IPR018501]", "DDX18/Has1, DEAD-box helicase domain [IPR044773]", "DDX41, DEAD-box helicase domain [IPR044113]", "DDX47/Rrp3, DEAD-box helicase domain [IPR044765]", "DDX52/Rok1, DEAD-box helicase domain [IPR044764]", "DEAD box protein 17, ATP-binding domain [IPR046330]", "DEAD/DEAH box helicase domain [IPR011545]", "DEAD2 [IPR010614]", "DEK, C-terminal [IPR014876]", "DEUBAD domain [IPR044867]", "DExH-box ATP-dependent RNA helicase, R3H domain [IPR034083]", "DFDF domain [IPR025762]", "DHHA1 domain [IPR003156]", "DHX15, DEXH-box helicase domain [IPR044756]", "DHX8/ Prp22, DEXH-box helicase domain [IPR044762]", "DHX9, DEXH-box helicase domain [IPR044447]", "DHX9, first double-stranded RNA binding domain [IPR044445]", "DHX9, second double-stranded RNA binding domain [IPR044446]", "DJ-1/PfpI [IPR002818]", "DMAP1-binding domain [IPR010506]", "DNA (cytosine-5)-methyltransferase 1, replication foci domain [IPR022702]", "DNA binding HTH domain, Psq-type [IPR007889]", "DNA damage inducible protein 1 ubiquitin-like domain [IPR033882]", "DNA fragmentation factor 45kDa, middle domain [IPR015121]", "DNA ligase 3, BRCT domain [IPR031916]", "DNA ligase, ATP-dependent, C-terminal [IPR012309]", "DNA ligase, ATP-dependent, N-terminal [IPR012308]", "DNA ligase, ATP-dependent, central [IPR012310]", "DNA mismatch repair protein MutS, C-terminal [IPR000432]", "DNA mismatch repair protein MutS, clamp [IPR007861]", "DNA mismatch repair protein MutS, connector domain [IPR007860]", "DNA mismatch repair protein MutS, core [IPR007696]", "DNA mismatch repair protein MutS-like, N-terminal [IPR007695]", "DNA polymerase epsilon, catalytic subunit A, C-terminal [IPR013697]", "DNA replication complex GINS protein SLD5, C-terminal [IPR031633]", "DNA replication factor RFC1, C-terminal [IPR013725]", "DNA topoisomerase 2, TOPRIM domain [IPR034157]", "DNA topoisomerase I, DNA binding, eukaryotic-type [IPR008336]", "DNA topoisomerase I, catalytic core, eukaryotic-type [IPR013500]", "DNA topoisomerase I, eukaryotic-type [IPR013499]", "DNA topoisomerase, type IIA, domain A [IPR002205]", "DNA topoisomerase, type IIA, subunit B, domain 2 [IPR013506]", "DNA-dependent protein kinase catalytic subunit, CC3 [IPR012582]", "DNA-dependent protein kinase catalytic subunit, CC5 [IPR045581]", "DNA-dependent protein kinase catalytic subunit, catalytic domain [IPR037706]", "DNA-directed DNA polymerase, family B, exonuclease domain [IPR006133]", "DNA-directed DNA polymerase, family B, multifunctional domain [IPR006134]", "DNA-directed RNA polymerase I subunit RPA2, domain 4 [IPR009674]", "DNA-directed RNA polymerase III subunit RPC1, C-terminal [IPR035698]", "DNA-directed RNA polymerase III subunit RPC1, N-terminal [IPR035697]", "DNA-directed RNA polymerase, N-terminal [IPR029262]", "DNA-directed RNA polymerase, RpoA/D/Rpb3-type [IPR011263]", "DNA-directed RNA polymerase, insert domain [IPR011262]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120]", "DNA-repair protein Xrcc1, N-terminal [IPR002706]", "DNA2/NAM7 helicase, helicase domain [IPR041677]", "DNA2/NAM7 helicase-like, C-terminal [IPR041679]", "DOCKER domain [IPR027357]", "DPF1-3, N-terminal domain [IPR025750]", "DSBA-like thioredoxin domain [IPR001853]", "DTHCT [IPR012542]", "DWNN domain [IPR014891]", "DZF domain [IPR006561]", "Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791]", "Dbl homology (DH) domain [IPR000219]", "Death domain [IPR000488]", "Dedicator of cytokinesis C, C2 domain [IPR037808]", "Dedicator of cytokinesis C/D, N-terminal [IPR021816]", "Dehydrogenase, E1 component [IPR001017]", "Deoxynucleoside kinase domain [IPR031314]", "Desmoplakin, SH3 domain [IPR041615]", "Desmoplakin, spectrin-like domain [IPR041573]", "Deubiquitinating enzyme MINDY-3/4, conserved domain [IPR025257]", "Diacylglycerol kinase, catalytic domain [IPR001206]", "Diaphanous autoregulatory (DAD) domain [IPR014767]", "Dihydrofolate reductase domain [IPR001796]", "Dilute domain [IPR002710]", "Dipeptidyl peptidase 8 /9 ,N-terminal [IPR045785]", "Dipeptidylpeptidase IV, N-terminal domain [IPR002469]", "Dis3-like cold-shock domain 2 [IPR041505]", "Disintegrin domain [IPR001762]", "Disulphide isomerase [IPR005788]", "DnaJ domain [IPR001623]", "DnaJ-like protein C11, C-terminal [IPR024586]", "Domain of unknown function DUF1087 [IPR009463]", "Domain of unknown function DUF1115 [IPR010541]", "Domain of unknown function DUF1605 [IPR011709]", "Domain of unknown function DUF1731 [IPR013549]", "Domain of unknown function DUF1747 [IPR013719]", "Domain of unknown function DUF1899 [IPR015048]", "Domain of unknown function DUF3350 [IPR021785]", "Domain of unknown function DUF3385, target of rapamycin protein [IPR024585]", "Domain of unknown function DUF3456 [IPR021852]", "Domain of unknown function DUF3480 [IPR022557]", "Domain of unknown function DUF3517 [IPR021905]", "Domain of unknown function DUF382 [IPR007180]", "Domain of unknown function DUF4149 [IPR025423]", "Domain of unknown function DUF4217 [IPR025313]", "Domain of unknown function DUF4749 [IPR031847]", "Domain of unknown function DUF5600 [IPR040990]", "Domain of unknown function DUF5921 [IPR045803]", "Double-stranded RNA-binding domain [IPR014720]", "Down-regulated-in-metastasis protein [IPR011430]", "Drebrin-like protein, SH3 domain [IPR035717]", "Drought induced 19 protein type, zinc-binding domain [IPR008598]", "Dual specificity phosphatase, catalytic domain [IPR000340]", "Dual specificity protein phosphatase domain [IPR020422]", "Dullard phosphatase domain, eukaryotic [IPR011948]", "Dynamin GTPase effector [IPR003130]", "Dynamin stalk domain [IPR000375]", "Dynamin, GTPase domain [IPR001401]", "Dynamin, N-terminal [IPR045063]", "Dynamin-like GTPase OPA1, C-terminal [IPR045817]", "Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]", "Dynein associated protein [IPR022157]", "Dynein heavy chain AAA lid domain [IPR041658]", "Dynein heavy chain region D6 P-loop domain [IPR004273]", "Dynein heavy chain, AAA 5 extension domain [IPR041466]", "Dynein heavy chain, AAA module D4 [IPR024317]", "Dynein heavy chain, ATP-binding dynein motor region [IPR035706]", "Dynein heavy chain, C-terminal domain [IPR041228]", "Dynein heavy chain, coiled coil stalk [IPR024743]", "Dynein heavy chain, hydrolytic ATP-binding dynein motor region [IPR035699]", "Dynein heavy chain, linker [IPR013602]", "Dynein heavy chain, tail [IPR013594]", "Dyskerin-like [IPR012960]", "E2 binding [IPR014929]", "E3 ligase, CCCH-type zinc finger [IPR041367]", "E3 ubiquitin ligase EDD, ubiquitin-associated domain [IPR024725]", "E3 ubiquitin ligase UBR4, C-terminal [IPR025704]", "E3 ubiquitin ligase, domain of unknown function DUF908 [IPR010309]", "E3 ubiquitin ligase, domain of unknown function DUF913 [IPR010314]", "E3 ubiquitin-protein ligase RNF114, RING finger, HC subclass [IPR042716]", "E3 ubiquitin-protein ligase UBR4, N-terminal [IPR045841]", "EB1, C-terminal [IPR004953]", "EBP50, C-terminal [IPR015098]", "ECSIT, C-terminal domain [IPR029342]", "EF hand associated, type-1 [IPR013566]", "EF hand associated, type-2 [IPR013567]", "EF-hand domain [IPR002048]", "EF-hand domain, type 1 [IPR015153]", "EF-hand domain, type 2 [IPR015154]", "EF-hand, Ca insensitive [IPR014837]", "EFG, domain V [IPR035649]", "EGF-like calcium-binding domain [IPR001881]", "EGF-like domain [IPR000742]", "EGF-like domain, extracellular [IPR013111]", "EH domain [IPR000261]", "EH domain-containing protein, N-terminal [IPR031692]", "EIF2AK2, first double-stranded RNA binding domain [IPR044452]", "EIF2AK2, second double-stranded RNA binding domain [IPR044453]", "ELM2 domain [IPR000949]", "ELMO domain [IPR006816]", "ENTH domain [IPR013809]", "ER membrane protein complex subunit 1, C-terminal [IPR011678]", "ER membrane protein complex subunit 7, beta-sandwich domain [IPR019008]", "ERAP1-like C-terminal domain [IPR024571]", "ERCC3/RAD25/XPB helicase, C-terminal domain [IPR032438]", "ERM family, FERM domain C-lobe [IPR041789]", "ERV/ALR sulfhydryl oxidase domain [IPR017905]", "ERdj5, C-terminal thioredoxin domain [IPR035674]", "ERdj5, first thioredoxin domain [IPR035673]", "ERp29, N-terminal [IPR012883]", "EWS, RNA recognition motif [IPR034869]", "EXPERA domain [IPR033118]", "Electron transfer flavoprotein, alpha subunit, C-terminal [IPR014731]", "Electron transfer flavoprotein, alpha subunit, N-terminal [IPR033947]", "Electron transfer flavoprotein, alpha/beta-subunit, N-terminal [IPR014730]", "Electron transfer flavoprotein, beta subunit, N-terminal [IPR033948]", "Elongation Factor G, domain II [IPR041095]", "Elongation factor 1 beta central acidic region, eukaryote [IPR018940]", "Elongation factor 1B gamma, C-terminal [IPR001662]", "Elongation factor EFG, domain V-like [IPR000640]", "Elongation factor G, domain III [IPR009022]", "Elongation factor Tu (EF-Tu), GTP-binding domain [IPR041709]", "Elongation factor Tu, domain 2 [IPR033720]", "Elp3/MiaB/NifB [IPR006638]", "Emerin, LEM domain [IPR034989]", "Endonuclease/exonuclease/phosphatase [IPR005135]", "Endophilin-A, SH3 domain [IPR035824]", "Endophilin-B1, BAR domain [IPR035695]", "Endoplasmic reticulum resident protein 29, C-terminal [IPR011679]", "Endoplasmic reticulum resident protein 44, TRX-like domain b [IPR041870]", "Endoplasmic reticulum resident protein 44, TRX-like domain b' [IPR041862]", "Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]", "Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]", "Enhancer of mRNA-decapping protein 4, WD40 repeat region [IPR032401]", "Enolase, C-terminal TIM barrel domain [IPR020810]", "Enolase, N-terminal [IPR020811]", "Enoyl-CoA hydratase/isomerase domain [IPR045004]", "Ephrin receptor ligand binding domain [IPR001090]", "Ephrin receptor, transmembrane domain [IPR027936]", "Ephrin type-A receptor 7, ligand binding domain [IPR034283]", "Era-type guanine nucleotide-binding (G) domain [IPR030388]", "Eukaryotic Ribosomal Protein L27, KOW domain [IPR041991]", "Eukaryotic glycogen debranching enzyme, N-terminal domain [IPR029436]", "Eukaryotic translation initiation factor 3 subunit E, N-terminal [IPR019010]", "Eukaryotic translation initiation factor 3 subunit G, N-terminal [IPR024675]", "Exocyst complex component EXOC2/Sec5, N-terminal domain [IPR039481]", "Exonuclease 1-like, PIN-like domain [IPR044752]", "Exonuclease, RNase T/DNA polymerase III [IPR013520]", "Exonuclease-1, H3TH domain [IPR037315]", "Exoribonuclease, phosphorolytic domain 1 [IPR001247]", "Exoribonuclease, phosphorolytic domain 2 [IPR015847]", "Exosome complex component CSL4, C-terminal [IPR019495]", "Exosome complex component, N-terminal domain [IPR025721]", "Exosome complex exonuclease RRP44, S1 domain [IPR033770]", "Exosome-associated factor Rrp6, N-terminal [IPR012588]", "Exportin-1, C-terminal [IPR014877]", "Exportin-1/Importin-beta-like [IPR013598]", "Exportin-2, C-terminal [IPR005043]", "Exportin-2, central domain [IPR013713]", "Exportin-5, C-terminal domain [IPR045478]", "Extended PHD (ePHD) domain [IPR034732]", "Extended synaptotagmin, C-terminal C2 domain [IPR037752]", "Extended synaptotagmin, C2A domain [IPR037733]", "Extended synaptotagmin, C2B domain [IPR037749]", "F-BAR domain [IPR031160]", "F-box domain [IPR001810]", "FACT complex subunit POB3-like, N-terminal PH domain [IPR035417]", "FACT complex subunit Spt16 domain [IPR013953]", "FACT complex subunit Spt16, N-terminal lobe domain [IPR029148]", "FACT complex subunit Spt16, peptidase M24-like domain [IPR033825]", "FAD dependent oxidoreductase [IPR006076]", "FAD dependent oxidoreductase, central domain [IPR032503]", "FAD linked oxidase, N-terminal [IPR006094]", "FAD-binding domain, PCMH-type [IPR016166]", "FAD-binding domain, ferredoxin reductase-type [IPR017927]", "FAD-dependent oxidoreductase 2, FAD binding domain [IPR003953]", "FAD-linked oxidase, C-terminal [IPR004113]", "FAD/NAD(P)-binding domain [IPR023753]", "FAF1, UBA-like domain [IPR044541]", "FANCI helical domain 1 [IPR029310]", "FANCI helical domain 2 [IPR029312]", "FANCI solenoid 1 cap [IPR029305]", "FANCI solenoid 1 domain [IPR029308]", "FANCI solenoid 2 domain [IPR029315]", "FANCI solenoid 3 domain [IPR029313]", "FANCI solenoid 4 domain [IPR029314]", "FAS-associated factor 1-like, UBX domain [IPR033043]", "FAST kinase leucine-rich [IPR010622]", "FAST kinase-like protein, subdomain 2 [IPR013579]", "FATC domain [IPR003152]", "FCH domain [IPR001060]", "FCP1 homology domain [IPR004274]", "FDF domain [IPR019050]", "FERM adjacent (FA) [IPR014847]", "FERM central domain [IPR019748]", "FERM domain [IPR000299]", "FERM, C-terminal PH-like domain [IPR018980]", "FERM, N-terminal [IPR018979]", "FF domain [IPR002713]", "FFD box [IPR025761]", "FGFR1 oncogene partner (FOP), N-terminal dimerisation domain [IPR018993]", "FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]", "FKBP12-rapamycin binding domain [IPR009076]", "FKBP3, basic tilted helix bundle domain [IPR041200]", "FY-rich, C-terminal [IPR003889]", "FY-rich, N-terminal [IPR003888]", "FYVE zinc finger [IPR000306]", "Far upstream element-binding protein, C-terminal [IPR015096]", "Fascin domain [IPR022768]", "Fatty acid desaturase domain [IPR005804]", "Fatty acyl-CoA reductase, C-terminal [IPR033640]", "Fatty acyl-coenzyme A reductase, NAD-binding domain [IPR013120]", "Fcf2 pre-rRNA processing, C-terminal [IPR014810]", "Ferric reductase transmembrane component-like domain [IPR013130]", "Ferrochelatase, C-terminal [IPR033644]", "Ferrochelatase, N-terminal [IPR033659]", "Fibronectin type II domain [IPR000562]", "Fibronectin type III [IPR003961]", "First polo-box domain [IPR033701]", "Flavodoxin-like [IPR001094]", "Flavodoxin/nitric oxide synthase [IPR008254]", "Flavoprotein pyridine nucleotide cytochrome reductase [IPR001709]", "Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain [IPR008333]", "Follistatin-like, N-terminal [IPR003645]", "Fork head domain [IPR001766]", "Forkhead-associated (FHA) domain [IPR000253]", "Formin, FH2 domain [IPR015425]", "Formin, FH3 domain [IPR010472]", "Formin, GTPase-binding domain [IPR010473]", "Formyl transferase, N-terminal [IPR002376]", "Fragile X-related 1 protein, C-terminal core [IPR022034]", "Fragile X-related 1 protein, C-terminal region 1 [IPR032172]", "Fragile X-related 1 protein, C-terminal region 3 [IPR032177]", "Fragile X-related mental retardation protein, C-terminal region 2 [IPR032196]", "Fumarase C, C-terminal [IPR018951]", "Fumarate lyase, N-terminal [IPR022761]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal [IPR015939]", "Fumarylacetoacetase, N-terminal [IPR015377]", "Fumarylacetoacetase-like, C-terminal [IPR011234]", "Fxr1, tudor domain [IPR041560]", "Fzo/mitofusin HR2 domain [IPR006884]", "G-patch domain [IPR000467]", "G-protein, beta subunit [IPR001632]", "G3BP1, RNA recognition motif [IPR034374]", "G3BP2, RNA recognition motif [IPR034376]", "GAD domain [IPR029351]", "GAR domain [IPR003108]", "GAT domain [IPR004152]", "GB1/RHD3-type guanine nucleotide-binding (G) domain [IPR030386]", "GCC2, Rab binding domain [IPR032023]", "GHMP kinase N-terminal domain [IPR006204]", "GHMP kinase, C-terminal domain [IPR013750]", "GINS complex protein Sld5, alpha-helical domain [IPR038749]", "GINS subunit, domain A [IPR021151]", "GMP phosphodiesterase, delta subunit [IPR008015]", "GMP synthase, C-terminal [IPR001674]", "GMP synthase, glutamine amidotransferase [IPR004739]", "GMP synthetase ATP pyrophosphatase domain [IPR025777]", "GNAT domain [IPR000182]", "GOLD domain [IPR009038]", "GPAT/DHAPAT, acyltransferase domain [IPR041728]", "GPR domain [IPR000965]", "GRAM domain [IPR004182]", "GRASP-type PDZ domain [IPR024958]", "GRB2, C-terminal SH3 domain [IPR035643]", "GRB2, N-terminal SH3 domain [IPR035641]", "GRIP domain [IPR000237]", "GRSF-1, RNA recognition motif 1 [IPR034425]", "GRSF-1, RNA recognition motif 2 [IPR034424]", "GRSF-1, RNA recognition motif 3 [IPR034426]", "GTP binding domain [IPR006073]", "GTP binding protein 1-like, GTP-binding domain [IPR035531]", "GTP binding protein, second domain [IPR031662]", "GTP-binding protein TrmE, N-terminal [IPR018948]", "GTP1/OBG domain [IPR006169]", "GTPase effector domain [IPR020850]", "GUCT [IPR012562]", "GYF domain [IPR003169]", "Galactokinase, N-terminal domain [IPR019539]", "Galactose mutarotase, N-terminal barrel [IPR031727]", "Gamma tubulin complex component protein, N-terminal [IPR041470]", "Gamma tubulin complex component, C-terminal [IPR040457]", "Gamma-adaptin ear (GAE) domain [IPR008153]", "Gamma-glutamyl cyclotransferase-like [IPR013024]", "Gelsolin-like domain [IPR007123]", "Gfo/Idh/MocA-like oxidoreductase, N-terminal [IPR000683]", "GlmS/AgaS, SIS domain 1 [IPR035466]", "GlmS/FrlB, SIS domain 2 [IPR035490]", "Glucosamine/galactosamine-6-phosphate isomerase [IPR006148]", "Glucose-6-phosphate dehydrogenase, C-terminal [IPR022675]", "Glucose-6-phosphate dehydrogenase, NAD-binding [IPR022674]", "Glucosidase 2 subunit beta-like [IPR036607]", "Glucosidase II beta subunit, N-terminal [IPR028146]", "Glucosyltransferase 24, catalytic domain [IPR040497]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal [IPR006096]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain [IPR006097]", "Glutaminase, EF-hand domain [IPR041541]", "Glutamine amidotransferase [IPR017926]", "Glutamine amidotransferase type 2 domain [IPR017932]", "Glutamine-Leucine-Glutamine, QLQ [IPR014978]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2 [IPR007638]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal [IPR007639]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain [IPR020059]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain [IPR020058]", "Glutaredoxin [IPR002109]", "Glutaredoxin, PICOT-like [IPR033658]", "Glutathione S-transferase, C-terminal [IPR004046]", "Glutathione S-transferase, C-terminal-like [IPR010987]", "Glutathione S-transferase, N-terminal [IPR004045]", "Glutathione S-transferases, class Zeta , C-terminal [IPR034330]", "Glutathione S-transferases, class Zeta , N-terminal [IPR034333]", "Glutathione synthase, substrate-binding domain [IPR004887]", "Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain [IPR020828]", "Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain [IPR020829]", "Glycerol-3-phosphate acyltransferase-like, C-terminal domain [IPR045520]", "Glycine cleavage T-protein, C-terminal barrel domain [IPR013977]", "Glycogen debranching enzyme, C-terminal [IPR032790]", "Glycogen debranching enzyme, central domain [IPR032788]", "Glycogen debranching enzyme, glucanotransferase domain [IPR032792]", "Glycogen synthase kinase 3, catalytic domain [IPR039192]", "Glycoside hydrolase 35, catalytic domain [IPR031330]", "Glycoside hydrolase family 18, catalytic domain [IPR001223]", "Glycoside hydrolase family 2, catalytic domain [IPR006103]", "Glycoside hydrolase family 20, catalytic domain [IPR015883]", "Glycoside hydrolase family 31, N-terminal domain [IPR025887]", "Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich [IPR006102]", "Glycosyl hydrolase family 30, TIM-barrel domain [IPR033453]", "Glycosyl hydrolase family 30, beta sandwich domain [IPR033452]", "Glycosyl hydrolase family 63, C-terminal [IPR031335]", "Glycosyl hydrolase family 63, N-terminal [IPR031631]", "Glycosyl hydrolase, family 13, catalytic domain [IPR006047]", "Glycosyl hydrolases family 2, sugar binding domain [IPR006104]", "Glycosyl transferase CAP10 domain [IPR006598]", "Glycosyltransferase 2-like [IPR001173]", "Glycyl-tRNA synthetase-like core domain [IPR033731]", "Glyoxalase domain-containing protein 4, C-terminal [IPR043194]", "Glyoxalase/fosfomycin resistance/dioxygenase domain [IPR004360]", "Guanine nucleotide exchange factor, N-terminal [IPR032691]", "Guanine nucleotide-binding protein-like 3, N-terminal domain [IPR014813]", "Guanylate kinase-like domain [IPR008144]", "Guanylate kinase/L-type calcium channel beta subunit [IPR008145]", "Guanylate-binding protein, N-terminal [IPR015894]", "Guanylate-binding protein/Atlastin, C-terminal [IPR003191]", "HBS1-like protein, N-terminal [IPR015033]", "HD domain [IPR006674]", "HD/PDEase domain [IPR003607]", "HDGF-related, PWWP domain [IPR035496]", "HECT domain [IPR000569]", "HELLS, N-terminal [IPR044753]", "HELP [IPR005108]", "HERC2, APC10 domain [IPR037976]", "HERC2, zinc finger, ZZ-type [IPR041987]", "HHH domain 9 [IPR041692]", "HIRAN domain [IPR014905]", "HIT-like domain [IPR011146]", "HR1 rho-binding domain [IPR011072]", "HRDC domain [IPR002121]", "HSPA4, nucleotide-binding domain [IPR042052]", "HSPA4L, nucleotide-binding domain [IPR042708]", "HSPH1, nucleotide-binding domain [IPR042053]", "HTH CenpB-type DNA-binding domain [IPR006600]", "HTTM [IPR011020]", "HUWE1, UBA domain [IPR041918]", "Heat shock 70kDa protein 14, nucleotide-binding domain [IPR042049]", "Heat shock chaperonin-binding [IPR006636]", "Heat shock protein DnaJ, cysteine-rich domain [IPR001305]", "Heat shock protein Hsp90, N-terminal [IPR020575]", "Heat shock protein beta-1, ACD domain [IPR037876]", "Helical and beta-bridge domain [IPR010643]", "Helicase XPB/Ssl2, N-terminal domain [IPR032830]", "Helicase domain [IPR007807]", "Helicase superfamily 1/2, ATP-binding domain [IPR014001]", "Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type [IPR014013]", "Helicase, C-terminal [IPR001650]", "Helicase-associated domain [IPR007502]", "Helicase-like, DEXD box c2 type [IPR006554]", "Helicase/SANT-associated domain [IPR014012]", "Helicase/UvrB, N-terminal [IPR006935]", "Helix-hairpin-helix DNA-binding motif, class 1 [IPR003583]", "Helix-turn-helix DNA-binding domain of Spt6 [IPR028088]", "Hemimethylated DNA-binding domain [IPR011722]", "Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 1 [IPR034544]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 2 [IPR034548]", "Heterogeneous nuclear ribonucleoprotein R, RNA recognition motif 2 [IPR034411]", "Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]", "Hexokinase, C-terminal [IPR022673]", "Hexokinase, N-terminal [IPR022672]", "High mobility group box domain 5 [IPR029215]", "High mobility group box domain [IPR009071]", "Histidine kinase domain [IPR005467]", "Histidine kinase/HSP90-like ATPase [IPR003594]", "Histone H2A, C-terminal domain [IPR032454]", "Histone H2A/H2B/H3 [IPR007125]", "Histone acetyl transferase HAT1 N-terminal [IPR019467]", "Histone deacetylase domain [IPR023801]", "Histone deacetylase interacting domain [IPR013194]", "Histone-arginine methyltransferase CARM1, N-terminal [IPR020989]", "Histone-binding protein RBBP4, N-terminal [IPR022052]", "HnRNP M, nuclear localisation signal [IPR024666]", "Homeobox domain [IPR001356]", "Homeobox domain, metazoa [IPR020479]", "Homocysteine-binding domain [IPR003726]", "Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120]", "HuR, RNA recognition motif 2 [IPR034996]", "Hyaluronan/mRNA-binding protein [IPR006861]", "Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain [IPR013746]", "Hydroxymethylglutaryl-coenzyme A synthase, N-terminal [IPR013528]", "I/LWEQ domain [IPR002558]", "IBR domain [IPR002867]", "IF2a, S1-like domain [IPR044126]", "IGF2BP1, RNA recognition motif 1 [IPR034837]", "IGF2BP1, RNA recognition motif 2 [IPR034842]", "IGF2BP3, RNA recognition motif 2 [IPR034844]", "IMD/I-BAR domain [IPR013606]", "IMP dehydrogenase/GMP reductase [IPR001093]", "IPT domain [IPR002909]", "IRG-type guanine nucleotide-binding (G) domain [IPR030385]", "IRS-type PTB domain [IPR002404]", "IRSp53, SH3 domain [IPR035594]", "ISWI, HAND domain [IPR015194]", "Ima1, N-terminal domain [IPR018617]", "Immunoglobulin C1-set [IPR003597]", "Immunoglobulin I-set [IPR013098]", "Immunoglobulin V-set domain [IPR013106]", "Immunoglobulin subtype 2 [IPR003598]", "Immunoglobulin subtype [IPR003599]", "Immunoglobulin-like domain [IPR007110]", "Importin-alpha, importin-beta-binding domain [IPR002652]", "Importin-beta, N-terminal domain [IPR001494]", "Initiation factor eIF-4 gamma, MA3 [IPR003891]", "Inner centromere protein, ARK-binding domain [IPR005635]", "Integrator complex subunit 11, MBL-fold [IPR041897]", "Integrator complex subunit 14, C-terminal [IPR045814]", "Integrator complex subunit 3, N-terminal [IPR019333]", "Integrin beta N-terminal [IPR033760]", "Integrin beta subunit, VWA domain [IPR002369]", "Integrin beta subunit, cytoplasmic domain [IPR014836]", "Integrin beta subunit, tail [IPR012896]", "Integrin beta, epidermal growth factor-like domain 1 [IPR040622]", "Integrin-linked protein kinase, pseudokinase domain [IPR035692]", "Intermediate filament head, DNA-binding domain [IPR006821]", "Intermediate filament, rod domain [IPR039008]", "Intracellular hyaluronan-binding protein 4, N-terminal domain [IPR032381]", "Ion transporter-like, CBS domain [IPR044751]", "Iron sulphur domain-containing, mitoNEET, N-terminal [IPR019610]", "Iron-binding zinc finger, CDGSH type [IPR018967]", "Isochorismatase-like [IPR000868]", "Isoleucyl tRNA synthetase type 1, anticodon-binding domain [IPR033708]", "Isoleucyl tRNA synthetase type 2, anticodon-binding domain [IPR033709]", "Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain [IPR044861]", "Isopropylmalate dehydrogenase-like domain [IPR024084]", "JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]", "JNK-interacting protein, leucine zipper II [IPR032486]", "JNK/Rab-associated protein-1, N-terminal [IPR019143]", "JmjC domain [IPR003347]", "Jumonji, helical domain [IPR041070]", "K Homology domain [IPR004087]", "K Homology domain, type 1 [IPR004088]", "K Homology domain, type 2 [IPR004044]", "KASH domain [IPR012315]", "KHDRBS, Qua1 domain [IPR032571]", "KMT2A, PHD domain 1 [IPR042023]", "KMT2A, PHD domain 2 [IPR042025]", "KMT2A, PHD domain 3 [IPR044133]", "KMT2A, ePHD domain [IPR041958]", "KOW [IPR005824]", "Kinase associated domain 1 (KA1) [IPR001772]", "Kindlin-2, N-terminal [IPR040790]", "Kindlin/fermitin, PH domain [IPR037837]", "Kinesin motor domain [IPR001752]", "Kinesin-associated [IPR032405]", "Kinesin-associated microtubule-binding domain [IPR025901]", "Kinesin-like [IPR022164]", "Kinesin-like protein Kif23, Arf6-interacting domain [IPR032384]", "Kri1-like, C-terminal [IPR024626]", "Krr1, KH1 domain [IPR041174]", "Ku, C-terminal [IPR014893]", "Ku70/Ku80 C-terminal arm [IPR005160]", "Ku70/Ku80 beta-barrel domain [IPR006164]", "Ku70/Ku80, N-terminal alpha/beta [IPR005161]", "L27 domain [IPR004172]", "L27 domain, C-terminal [IPR014775]", "LAIKA domain [IPR045353]", "LARP4, RNA recognition motif [IPR034903]", "LARP5, RNA recognition motif [IPR034900]", "LARP7, RNA recognition motif 1 [IPR034887]", "LARP7, RNA recognition motif 2 [IPR034910]", "LEM domain [IPR003887]", "LEM-like domain [IPR013146]", "LETM1, ribosome-binding domain [IPR033122]", "LETM1-like [IPR011685]", "LIS1 homology motif [IPR006594]", "LSM domain, eukaryotic/archaea-type [IPR001163]", "LSM-interacting domain [IPR008669]", "La protein, xRRM domain [IPR014886]", "La-related protein 7, La domain [IPR034946]", "La-type HTH domain [IPR006630]", "Lactate/malate dehydrogenase, C-terminal [IPR022383]", "Lactate/malate dehydrogenase, N-terminal [IPR001236]", "Lamin tail domain [IPR001322]", "Lamin-B receptor of TUDOR domain [IPR019023]", "Lamina-associated polypeptide 2 alpha, C-terminal [IPR021623]", "Laminin G domain [IPR001791]", "Large proline-rich protein BAG6 [IPR021925]", "Lasp1, SH3 domain [IPR035630]", "Legume-like lectin [IPR005052]", "Lens epithelium-derived growth factor, integrase-binding domain [IPR021567]", "Lethal giant larvae homologue 2 [IPR013577]", "Leucine zipper, homeobox-associated [IPR003106]", "Leucine-rich repeat N-terminal domain [IPR000372]", "Linker histone H1/H5, domain H15 [IPR005818]", "Listerin, zinc finger, RING-type [IPR039804]", "Lon, substrate-binding domain [IPR003111]", "Longin domain [IPR010908]", "Lsm14-like, N-terminal [IPR025609]", "Lsm16, N-terminal [IPR034107]", "LsmAD domain [IPR009604]", "Lysine-tRNA ligase, class II, N-terminal [IPR044136]", "Lysophosphatidylcholine acyltransferase LPCAT1-like [IPR045252]", "Lysyl-tRNA synthetase, class II, C-terminal [IPR018149]", "M60-like domain, N-terminal [IPR035423]", "MAGE homology domain [IPR002190]", "MAN1, RNA recognition motif [IPR034394]", "MATH/TRAF domain [IPR002083]", "MCM N-terminal domain [IPR027925]", "MCM OB domain [IPR033762]", "MCM domain [IPR001208]", "MCM, AAA-lid domain [IPR041562]", "MD-2-related lipid-recognition domain [IPR003172]", "MDM2-binding protein, N-terminal domain [IPR029421]", "MDM2-binding protein, central domain [IPR029420]", "MDN2-binding protein, C-terminal domain [IPR029418]", "MEF-2, RNA recognition motif 1 [IPR034630]", "MEF-2, RNA recognition motif 3 [IPR034631]", "MENTAL domain [IPR019498]", "MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]", "MHC class I, alpha chain, C-terminal [IPR010579]", "MHC class I-like antigen recognition-like [IPR011161]", "MIF4G-like, type 1 [IPR015172]", "MIF4G-like, type 2 [IPR015174]", "MIF4G-like, type 3 [IPR003890]", "MIRO domain [IPR020860]", "MIT domain [IPR007330]", "MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding [IPR021043]", "MMS19, C-terminal [IPR024687]", "MMS19, N-terminal [IPR029240]", "MOSC, N-terminal beta barrel [IPR005303]", "MPN domain [IPR037518]", "MPP2, SH3 domain [IPR035602]", "MPP6, SH3 domain [IPR035603]", "MRG domain [IPR026541]", "MRH domain [IPR044865]", "MRPL44, double-stranded RNA binding domain [IPR044444]", "MTMR6, PH-GRAM domain [IPR035998]", "Macro domain [IPR002589]", "Mad3/Bub1 homology region 1 [IPR013212]", "Major facilitator superfamily domain [IPR020846]", "Major sperm protein (MSP) domain [IPR000535]", "Malectin domain [IPR021720]", "Malic enzyme, N-terminal domain [IPR012301]", "Malic enzyme, NAD-binding [IPR012302]", "Man1/Src1, C-terminal [IPR018996]", "Manganese/iron superoxide dismutase, C-terminal [IPR019832]", "Manganese/iron superoxide dismutase, N-terminal [IPR019831]", "MaoC-like dehydratase domain [IPR002539]", "Marvel domain [IPR008253]", "Matrin-3, RNA recognition motif 1 [IPR034928]", "Matrin-3, RNA recognition motif 2 [IPR034930]", "Matrin/U1-C, C2H2-type zinc finger [IPR000690]", "Matrin/U1-C-like, C2H2-type zinc finger [IPR003604]", "Mcm6, C-terminal winged-helix domain [IPR041024]", "Metallo-beta-lactamase [IPR001279]", "Metastasis-associated protein MTA1, R1 domain [IPR035170]", "Metaxin, glutathione S-transferase domain [IPR033468]", "Methionine synthase, B12-binding domain [IPR033706]", "Methionine--tRNA ligase, N-terminal [IPR041598]", "Methioninyl-tRNA synthetase core domain [IPR033911]", "Methionyl-tRNA synthetase, anticodon-binding domain [IPR041872]", "Methionyl/Leucyl tRNA synthetase [IPR015413]", "Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding [IPR013155]", "Methyl-CpG DNA binding [IPR001739]", "Methyl-CpG binding protein 2/3, C-terminal domain [IPR025884]", "Methyl-CpG-binding domain protein 2/3, p55-binding region [IPR032343]", "Methylglyoxal synthase-like domain [IPR011607]", "Methylthiotransferase, N-terminal [IPR013848]", "Methyltransferase domain 25 [IPR041698]", "Methyltransferase type 11 [IPR013216]", "Methyltransferase type 12 [IPR013217]", "Mib-herc2 [IPR010606]", "Midasin AAA lid domain 5 [IPR041190]", "Midasin, AAA lid domain 7 [IPR040848]", "Midline-1, COS domain [IPR040859]", "Minichromosome loss protein Mcl1, middle region [IPR022100]", "Mitochondrial apoptosis-inducing factor, C-terminal domain [IPR029324]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs [IPR034884]", "Mitochondrial degradasome RNA helicase subunit, C-terminal domain [IPR022192]", "Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564]", "Mitochondrial ribosomal protein L46 NUDIX [IPR033650]", "MnmE, helical domain [IPR025867]", "MoaB/Mog domain [IPR001453]", "Molybdenum cofactor sulfurase, C-terminal [IPR005302]", "Molybdopterin oxidoreductase [IPR006656]", "Molybdopterin oxidoreductase, 4Fe-4S domain [IPR006963]", "Mre11 nuclease, N-terminal metallophosphatase domain [IPR041796]", "Mre11, DNA-binding [IPR007281]", "Mu homology domain [IPR028565]", "Mu2, C-terminal domain [IPR043512]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal [IPR031717]", "Multiple myeloma tumor-associated protein 2-like, N-terminal [IPR019315]", "Myb domain [IPR017930]", "Myo-inositol-1-phosphate synthase, GAPDH-like [IPR013021]", "Myosin VI, cargo binding domain [IPR032412]", "Myosin head, motor domain [IPR001609]", "Myosin phosphatase-RhoA interacting protein, PH domain [IPR039597]", "Myosin tail [IPR002928]", "Myosin, N-terminal, SH3-like [IPR004009]", "Myotubularin-like phosphatase domain [IPR010569]", "Myristoyl-CoA:protein N-myristoyltransferase, C-terminal [IPR022677]", "Myristoyl-CoA:protein N-myristoyltransferase, N-terminal [IPR022676]", "N-acetylgalactosaminyltransferase [IPR045885]", "N-acetylneuraminic acid synthase, N-terminal [IPR013132]", "NAD(P) binding domain of glutamate dehydrogenase [IPR033922]", "NAD(P) transhydrogenase, alpha subunit, C-terminal [IPR024605]", "NAD-dependent epimerase/dehydratase [IPR001509]", "NAD/GMP synthase [IPR022310]", "NADH pyrophosphatase-like, N-terminal [IPR015375]", "NADH-quinone oxidoreductase, chain G, C-terminal [IPR015405]", "NADH-quinone oxidoreductase, subunit D [IPR001135]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain [IPR011538]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain [IPR019575]", "NADH:ubiquinone oxidoreductase intermediate-associated protein 30 [IPR013857]", "NADH:ubiquinone oxidoreductase, 30kDa subunit [IPR001268]", "NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding [IPR019574]", "NADH:ubiquinone oxidoreductase-like, 20kDa subunit [IPR006137]", "NADP transhydrogenase beta-like domain [IPR034300]", "NADP-dependent oxidoreductase domain [IPR023210]", "NDUFB9, LYR domain [IPR045292]", "NECAP, PHear domain [IPR012466]", "NEDD8 ultimate buster 1, ubiquitin-like domain [IPR041207]", "NET domain [IPR027353]", "NF-kappaB-repression factor, R3H domain [IPR034071]", "NFACT protein, C-terminal [IPR021846]", "NFACT, RNA-binding domain [IPR008532]", "NGN domain [IPR005100]", "NGN domain, eukaryotic [IPR039385]", "NHL2, NHL repeat domain [IPR045302]", "NLE [IPR012972]", "NOG, C-terminal [IPR012973]", "NOG1, N-terminal helical domain [IPR041623]", "NOP5, N-terminal [IPR012974]", "NOPS [IPR012975]", "NOSIC [IPR012976]", "NOT2/NOT3/NOT5, C-terminal [IPR007282]", "NP60, PWWP domain [IPR035501]", "NPL4, zinc-binding putative [IPR007716]", "NSD, Cys-His rich domain [IPR041306]", "NUC153 [IPR012580]", "NUC205 domain [IPR012584]", "NUDIX hydrolase [IPR020476]", "NUDIX hydrolase domain [IPR000086]", "NVL2, nucleolin binding domain [IPR031996]", "Nascent polypeptide-associated complex NAC domain [IPR002715]", "Neurobeachin-like, DUF1088 [IPR010508]", "Neurobeachin/BDCP, DUF4704 [IPR031570]", "Nicastrin, small lobe [IPR041084]", "Nicotinamide phosphoribosyltransferase, N-terminal domain [IPR041529]", "Nicotinate/nicotinamide phosphoribosyltransferase [IPR041525]", "Niemann-Pick C1, N-terminal [IPR032190]", "Nin one binding (NOB1) Zn-ribbon-like [IPR014881]", "Nischarin, PX domain [IPR037904]", "Nitric oxide synthase-interacting protein, zinc-finger [IPR031790]", "Nop domain [IPR002687]", "Nop2p [IPR011023]", "Npc2 like, ML domain [IPR033916]", "Nrap protein domain 1 [IPR035082]", "Nrap protein, domain 2 [IPR035367]", "Nrap protein, domain 3 [IPR035368]", "Nrap protein, domain 4 [IPR035369]", "Nrap protein, domain 5 [IPR035370]", "Nrap protein, domain 6 [IPR035371]", "Nuclear RNA export factor Tap, RNA-binding domain [IPR015245]", "Nuclear condensin complex subunit 3, C-terminal domain [IPR025977]", "Nuclear migration protein nudC [IPR032572]", "Nuclear pore complex protein Nup214, phenylalanine-glycine (FG) domain [IPR041553]", "Nuclear pore complex, NUP2/50/61 [IPR015007]", "Nuclear pore localisation protein NPL4, C-terminal [IPR007717]", "Nuclear pore localisation protein Npl4, ubiquitin-like domain [IPR024682]", "Nuclear protein 96 [IPR021967]", "Nuclear transport factor 2 domain [IPR002075]", "Nuclear transport factor 2, eukaryote [IPR018222]", "Nuclear-interacting partner of ALK/Rsm1-like [IPR013909]", "Nucleolar GTP-binding protein 1, Rossman-fold domain [IPR010674]", "Nucleolar GTP-binding protein 2, N-terminal domain [IPR012971]", "Nucleolar complex-associated protein 3, N-terminal [IPR011501]", "Nucleolar protein 7, C-terminal [IPR012579]", "Nucleolar protein 8, RNA recognition motif [IPR034138]", "Nucleolin, RNA recognition motif 1 [IPR034230]", "Nucleolin, RNA recognition motif 2 [IPR034233]", "Nucleolin, RNA recognition motif 3 [IPR034234]", "Nucleolin, RNA recognition motif 4 [IPR034235]", "Nucleophosmin, C-terminal [IPR032569]", "Nucleoplasmin core domain [IPR024057]", "Nucleoporin Nup153, N-terminal [IPR013913]", "Nucleoporin Nup188, N-terminal [IPR018864]", "Nucleoporin Nup54, alpha-helical domain [IPR025712]", "Nucleoporin, NSP1-like, C-terminal [IPR007758]", "Nucleoporin, Nup133/Nup155-like, C-terminal [IPR007187]", "Nucleoporin, Nup133/Nup155-like, N-terminal [IPR014908]", "Nucleoprotein TPR/MLP1 [IPR012929]", "Nucleoside diphosphate kinase-like domain [IPR034907]", "Nucleoside phosphorylase domain [IPR000845]", "Nucleotide exchange factor Fes1 [IPR013918]", "Nucleotidyl transferase domain [IPR005835]", "NudC N-terminal domain [IPR025934]", "NudC domain-containing protein 2, p23 domain [IPR037902]", "NuoE domain [IPR042128]", "Nup358/RanBP2 E3 ligase domain [IPR022011]", "Nup54, C-terminal interacting domain [IPR040985]", "NusG, N-terminal [IPR006645]", "O-GlcNAc transferase, C-terminal [IPR029489]", "OB-fold nucleic acid binding domain, AA-tRNA synthetase-type [IPR004365]", "OBG-type guanine nucleotide-binding (G) domain [IPR031167]", "OCRE domain [IPR041591]", "OTU domain [IPR003323]", "Occludin homology domain [IPR010844]", "Orotate phosphoribosyl transferase domain [IPR004467]", "Orotidine 5'-phosphate decarboxylase domain [IPR001754]", "Ovarian carcinoma immunoreactive antigen domain [IPR009764]", "Oxidoreductase FAD/NAD(P)-binding [IPR001433]", "Oxidoreductase, N-terminal domain [IPR041694]", "Oxoglutarate/iron-dependent dioxygenase [IPR005123]", "Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain [IPR019601]", "P-type ATPase, haloacid dehalogenase domain [IPR044492]", "P-type trefoil domain [IPR000519]", "PA domain [IPR003137]", "PABP, RNA recognition motif 2 [IPR045305]", "PACSIN1/PACSIN2, SH3 domain [IPR035743]", "PACSIN2, F-BAR domain [IPR037453]", "PADR1 domain [IPR012982]", "PAP/25A-associated [IPR002058]", "PARN, R3H domain [IPR034042]", "PB1 domain [IPR000270]", "PDIP3, RNA recognition motif [IPR034784]", "PDZ domain 6 [IPR041489]", "PDZ domain [IPR001478]", "PH-BEACH domain [IPR023362]", "PIK-related kinase [IPR014009]", "PIK-related kinase, FAT [IPR003151]", "PIN domain [IPR002716]", "PITH domain [IPR010400]", "PLAA family ubiquitin binding domain [IPR015155]", "PLD-like domain [IPR032803]", "POLO box domain [IPR000959]", "POPLD domain [IPR012590]", "POTRA domain [IPR034746]", "PP5, C-terminal metallophosphatase domain [IPR041753]", "PPIL4-like, cyclophilin domain [IPR035538]", "PPM-type phosphatase domain [IPR001932]", "PPP domain [IPR013235]", "PRMT5 arginine-N-methyltransferase [IPR035075]", "PRMT5, TIM barrel domain [IPR035247]", "PRMT5, oligomerisation domain [IPR035248]", "PRO8NT domain [IPR012591]", "PROCN domain [IPR012592]", "PROCT domain [IPR012984]", "PRP1 splicing factor, N-terminal [IPR010491]", "PRP8 domain IV core [IPR021983]", "PSF, NOPS domain [IPR034526]", "PSF, RNA recognition motif 1 [IPR034525]", "PSI domain [IPR016201]", "PSP, proline-rich [IPR006568]", "PSP1, RNA recognition motif 1 [IPR034522]", "PSP1, RNA recognition motif 2 [IPR034523]", "PTB/PI domain [IPR006020]", "PTBP1, RNA recognition motif 1 [IPR035000]", "PTBP1, RNA recognition motif 2-like [IPR021790]", "PTBP1, RNA recognition motif 3 [IPR035001]", "PUA domain [IPR002478]", "PUF60, RNA recognition motif 1 [IPR034209]", "PUF60, RNA recognition motif 2 [IPR034211]", "PUF60, RNA recognition motif 3 [IPR034212]", "PUL domain [IPR013535]", "PWI domain [IPR002483]", "PWWP domain [IPR000313]", "Paf1 complex subunit Cdc73, N-terminal domain [IPR032041]", "Palladin, C-terminal immunoglobulin-like domain [IPR033017]", "Palmitoyltransferase, DHHC domain [IPR001594]", "Pancreatic trypsin inhibitor Kunitz domain [IPR002223]", "Patatin-like phospholipase domain [IPR002641]", "Pentacotripeptide-repeat region of PRORP [IPR033443]", "Pep3/Vps18/deep orange [IPR007810]", "Peptidase C12, C-terminal domain [IPR041507]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase [IPR001578]", "Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394]", "Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615]", "Peptidase C2, calpain, catalytic domain [IPR001300]", "Peptidase C2, calpain, domain III [IPR022683]", "Peptidase C2, calpain, large subunit, domain III [IPR022682]", "Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal [IPR015211]", "Peptidase M1, membrane alanine aminopeptidase [IPR014782]", "Peptidase M12B, ADAM/reprolysin [IPR001590]", "Peptidase M12B, propeptide [IPR002870]", "Peptidase M13, C-terminal domain [IPR018497]", "Peptidase M13, N-terminal domain [IPR008753]", "Peptidase M14, carboxypeptidase A [IPR000834]", "Peptidase M16, C-terminal [IPR007863]", "Peptidase M16, N-terminal [IPR011765]", "Peptidase M16, middle/third domain [IPR032632]", "Peptidase M16C associated [IPR013578]", "Peptidase M17, leucyl aminopeptidase, C-terminal [IPR000819]", "Peptidase M17, leucyl aminopeptidase, N-terminal [IPR008283]", "Peptidase M20, dimerisation domain [IPR011650]", "Peptidase M24 [IPR000994]", "Peptidase M24, C-terminal domain [IPR032416]", "Peptidase M28 [IPR007484]", "Peptidase M3A/M3B catalytic domain [IPR001567]", "Peptidase M41 [IPR000642]", "Peptidase M41, FtsH extracellular [IPR011546]", "Peptidase M48 [IPR001915]", "Peptidase S16, Lon proteolytic domain [IPR008269]", "Peptidase S24/S26A/S26B/S26C [IPR015927]", "Peptidase S26 [IPR019533]", "Peptidase S53, activation domain [IPR015366]", "Peptidase S59, nucleoporin [IPR007230]", "Peptidase S8/S53 domain [IPR000209]", "Peptidase S8A, tripeptidyl peptidase II [IPR022229]", "Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375]", "Peptidase S9A, N-terminal domain [IPR023302]", "Peptidase family M60 domain [IPR031161]", "Peptide chain release factor class I [IPR000352]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type [IPR000297]", "Pericentriolar material 1 protein, C-terminal [IPR031446]", "Peripheral subunit-binding domain [IPR004167]", "Peroxiredoxin, C-terminal [IPR019479]", "Peroxisome membrane anchor protein Pex14p, N-terminal [IPR006785]", "PheRS DNA binding domain 2 [IPR040586]", "PheRS, DNA binding domain 1 [IPR040724]", "PheRS, DNA binding domain 3 [IPR040725]", "Phenylacetic acid degradation-related domain [IPR003736]", "Phenylalanine--tRNA ligase beta subunit, B1 domain [IPR040659]", "Phenylalanyl tRNA synthetase beta chain, core domain [IPR041616]", "Phenylalanyl-tRNA synthetase [IPR002319]", "Phosducin, thioredoxin-like domain [IPR024253]", "Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403]", "Phosphoadenosine phosphosulphate reductase [IPR002500]", "Phosphofructokinase domain [IPR000023]", "Phosphoglucose isomerase, SIS domain 1 [IPR035476]", "Phosphoglucose isomerase, SIS domain 2 [IPR035482]", "Phosphoinositide 3-kinase, accessory (PIK) domain [IPR001263]", "Phospholipase D/Transphosphatidylase [IPR001736]", "Phospholipase/carboxylesterase/thioesterase [IPR003140]", "Phospholipid/glycerol acyltransferase [IPR002123]", "Phosphopantetheine binding ACP domain [IPR009081]", "Phosphoribosylformylglycinamidine synthase, N-terminal [IPR040707]", "Phosphoribosylformylglycinamidine synthase, linker domain [IPR041609]", "Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain [IPR020561]", "Phosphoribosylglycinamide synthetase, C-domain [IPR020560]", "Phosphoribosylglycinamide synthetase, N-terminal [IPR020562]", "Phosphoribosyltransferase domain [IPR000836]", "Phosphorylated adapter RNA export protein, RNA-binding domain [IPR019385]", "Phosphotyrosine protein phosphatase I [IPR023485]", "Phox homology [IPR001683]", "Pinin/SDK [IPR006787]", "Pinin/SDK/MemA protein [IPR006786]", "Pirin, C-terminal domain [IPR008778]", "Pirin, N-terminal domain [IPR003829]", "Plasma membrane calcium transporting P-type ATPase, C-terminal [IPR022141]", "Pleckstrin homology domain 8 [IPR041680]", "Pleckstrin homology domain 9 [IPR041681]", "Pleckstrin homology domain [IPR001849]", "Pleckstrin homology domain, spectrin-type [IPR001605]", "Plectin/S10, N-terminal [IPR005326]", "Polo-like kinase 1, catalytic domain [IPR033702]", "Poly A polymerase, head domain [IPR002646]", "Poly(A) polymerase, RNA-binding domain [IPR007010]", "Poly(A) polymerase, central domain [IPR007012]", "Poly(A)-specific ribonuclease, RNA-binding [IPR014789]", "Poly(ADP-ribose) polymerase, catalytic domain [IPR012317]", "Poly(ADP-ribose) polymerase, regulatory domain [IPR004102]", "Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004]", "Polyamine biosynthesis domain [IPR030374]", "Polycomb protein, VEFS-Box [IPR019135]", "Polyketide synthase, C-terminal extension [IPR032821]", "Polyketide synthase, beta-ketoacyl synthase domain [IPR020841]", "Polyketide synthase, dehydratase domain [IPR020807]", "Polyketide synthase, enoylreductase domain [IPR020843]", "Polyketide synthase, ketoreductase domain [IPR013968]", "Polyketide synthase, phosphopantetheine-binding domain [IPR020806]", "Polymerase, nucleotidyl transferase domain [IPR002934]", "Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2 [IPR034798]", "Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain [IPR032319]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain [IPR015848]", "Polysaccharide biosynthesis domain [IPR021148]", "Pop1, N-terminal [IPR009723]", "Possible tRNA binding domain [IPR027992]", "Post-SET domain [IPR003616]", "Potassium channel tetramerisation-type BTB domain [IPR003131]", "Pre-PUA domain [IPR041366]", "Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term [IPR021718]", "Pre-mRNA polyadenylation factor Fip1 domain [IPR007854]", "Pre-mRNA processing factor 4 (PRP4)-like [IPR014906]", "Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal [IPR021786]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding [IPR019581]", "Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding [IPR019580]", "Pre-mRNA-splicing factor 19 [IPR013915]", "Pre-mRNA-splicing factor 3 [IPR013881]", "Pre-rRNA-processing protein Ipi1, N-terminal [IPR024679]", "Pre-rRNA-processing protein RIX1, N-terminal [IPR012583]", "Prenylcysteine lyase [IPR010795]", "Probable RNA-binding protein 19, RNA recognition motif 1 [IPR034418]", "Probable RNA-binding protein 19, RNA recognition motif 2 [IPR034417]", "Probable RNA-binding protein 19, RNA recognition motif 3 [IPR034419]", "Probable RNA-binding protein 19, RNA recognition motif 4 [IPR034420]", "Probable RNA-binding protein 19, RNA recognition motif 5 [IPR034423]", "Probable RNA-binding protein 19, RNA recognition motif 6 [IPR034421]", "Proliferating cell nuclear antigen, PCNA, C-terminal [IPR022649]", "Proliferating cell nuclear antigen, PCNA, N-terminal [IPR022648]", "Proline-tRNA ligase, class II, C-terminal [IPR016061]", "Prolyl 3,4-dihydroxylase TPA1/OFD1, N-terminal domain [IPR039558]", "Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]", "Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547]", "Prolyl 4-hydroxylase, alpha subunit [IPR006620]", "Prolyl-tRNA synthetase, catalytic domain [IPR033721]", "Propionyl-coenzyme A carboxylase, BT domain [IPR041265]", "Prostaglandin E synthase 2, C-terminal [IPR034335]", "Proteasomal ATPase OB C-terminal domain [IPR032501]", "Proteasome activator Blm10, mid region [IPR032430]", "Proteasome activator PA28, C-terminal domain [IPR003186]", "Proteasome activator PA28, N-terminal domain [IPR003185]", "Proteasome activator complex subunit 4 C-terminal domain [IPR021843]", "Proteasome alpha-subunit, N-terminal domain [IPR000426]", "Proteasome beta subunit, C-terminal [IPR024689]", "Proteasome component (PCI) domain [IPR000717]", "Protein Kinase B beta, catalytic domain [IPR034677]", "Protein Kinase B, pleckstrin homology domain [IPR039026]", "Protein O-mannosyl-transferase TMTC, DUF1736 [IPR013618]", "Protein RED, C-terminal [IPR012492]", "Protein disulfide-isomerase A3, first redox inactive TRX-like domain b [IPR041868]", "Protein disulfide-isomerase A4, TRX-like domain b [IPR041866]", "Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [IPR002219]", "Protein kinase domain [IPR000719]", "Protein kinase, C-terminal [IPR017892]", "Protein of unknown function DUF3504 [IPR021893]", "Protein of unknown function DUF3715 [IPR022188]", "Protein phosphatase 1 binding domain [IPR029334]", "Protein polybromo-1, Bromodomain 5 [IPR037968]", "Protein quaking, putative nuclear localisation signal [IPR032367]", "Protein-only RNase P, C-terminal [IPR031595]", "Protein-tyrosine phosphatase, catalytic [IPR003595]", "Prp31 C-terminal [IPR019175]", "Pseudouridine synthase I, TruA, alpha/beta domain [IPR020097]", "Pseudouridine synthase II, N-terminal [IPR002501]", "Pseudouridine synthase, TruD, insertion domain [IPR011760]", "Pterin-binding domain [IPR000489]", "Pumilio homology domain [IPR033133]", "PurE domain [IPR000031]", "PurM-like, C-terminal domain [IPR010918]", "PurM-like, N-terminal domain [IPR016188]", "Putative 5-3 exonuclease [IPR004859]", "Putative RNA methylase domain [IPR000241]", "Putative RNA-binding protein 27, RNA recognition motif [IPR034451]", "Putative WW-binding domain and destruction box [IPR033461]", "Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain [IPR004099]", "Pyrroline-5-carboxylate reductase, catalytic, N-terminal [IPR028939]", "Pyrroline-5-carboxylate reductase, dimerisation domain [IPR029036]", "Pyruvate carboxyltransferase [IPR000891]", "Pyruvate kinase, C-terminal [IPR015795]", "Pyruvate kinase, barrel [IPR015793]", "R3H domain [IPR001374]", "RABX5, catalytic core helical domain [IPR041545]", "RAD23A/RAD23B, UBA1 domain [IPR041811]", "RAD50, zinc hook [IPR013134]", "RAD51 interacting motif [IPR031419]", "RAP domain [IPR013584]", "RBM10, OCRE domain [IPR035618]", "RBM12, RNA recognition motif 1 [IPR034591]", "RBM12, RNA recognition motif 2 [IPR034594]", "RBM12, RNA recognition motif 3 [IPR034855]", "RBM12, RNA recognition motif 4 [IPR034856]", "RBM12, RNA recognition motif 5 [IPR034854]", "RBM14, RNA recognition motif 1 [IPR034506]", "RBM14, RNA recognition motif 2 [IPR034507]", "RBM15, RNA recognition motif 1 [IPR034470]", "RBM15, RNA recognition motif 2 [IPR034472]", "RBM15, RNA recognition motif 3 [IPR034473]", "RBM1CTR [IPR012604]", "RBM25, RNA recognition motif [IPR034268]", "RBM26, RNA recognition motif 1 [IPR034859]", "RBM26-like, RNA recognition motif 2 [IPR039511]", "RBM3/CIRBP, RNA recognition motif [IPR034278]", "RBM34, RNA recognition motif 1 [IPR034220]", "RBM34, RNA recognition motif 2 [IPR034221]", "RBM4, RNA recognition motif 1 [IPR034897]", "RBM4, RNA recognition motif 2 [IPR034898]", "RBM45, RNA recognition motif 1 [IPR034203]", "RBM45, RNA recognition motif 2 [IPR034206]", "RBM45, RNA recognition motif 3 [IPR034207]", "RBM45, RNA recognition motif 4 [IPR034208]", "RBM8, RNA recognition motif [IPR033744]", "RDD [IPR010432]", "RED-like, N-terminal [IPR012916]", "RH1 domain [IPR034743]", "RH2 domain [IPR034744]", "RHIM domain [IPR025735]", "RII binding domain [IPR018459]", "RING-type zinc-finger, LisH dimerisation motif [IPR027370]", "RIO kinase [IPR000687]", "RIO2 kinase winged helix domain, N-terminal [IPR015285]", "RIP1, Death domain [IPR037934]", "RL domain [IPR041252]", "RLI, domain 1 [IPR034348]", "RNA 3'-terminal phosphate cyclase domain [IPR023797]", "RNA 3'-terminal phosphate cyclase, insert domain [IPR013791]", "RNA binding activity-knot of a chromodomain [IPR025995]", "RNA exonuclease 4, DEDDh 3'-5' exonuclease domain [IPR037431]", "RNA helicase UPF1, 1B domain [IPR040812]", "RNA helicase UPF1, Cys/His rich zinc-binding domain [IPR018999]", "RNA helicase, DEAD-box type, Q motif [IPR014014]", "RNA polymerase III Rpc82, C -terminal [IPR008806]", "RNA polymerase III subunit RPC82-related, helix-turn-helix [IPR013197]", "RNA polymerase Rpb1, domain 1 [IPR007080]", "RNA polymerase Rpb1, domain 3 [IPR007066]", "RNA polymerase Rpb1, domain 4 [IPR007083]", "RNA polymerase Rpb1, domain 5 [IPR007081]", "RNA polymerase Rpb1, domain 6 [IPR007075]", "RNA polymerase Rpb1, domain 7 [IPR007073]", "RNA polymerase Rpb2, domain 2 [IPR007642]", "RNA polymerase Rpb2, domain 3 [IPR007645]", "RNA polymerase Rpb2, domain 4 [IPR007646]", "RNA polymerase Rpb2, domain 5 [IPR007647]", "RNA polymerase Rpb2, domain 7 [IPR007641]", "RNA polymerase Rpb7-like , N-terminal [IPR005576]", "RNA polymerase, N-terminal [IPR006592]", "RNA polymerase, Rpb5, N-terminal [IPR005571]", "RNA polymerase, alpha subunit [IPR000722]", "RNA polymerase, beta subunit, protrusion [IPR007644]", "RNA polymerase, subunit H/Rpb5 C-terminal [IPR000783]", "RNA recognition motif domain [IPR000504]", "RNA recognition motif domain, eukaryote [IPR003954]", "RNA recognition motif, spliceosomal PrP8 [IPR019582]", "RNA-binding S4 domain [IPR002942]", "RNA-binding domain, S1 [IPR022967]", "RNA-binding protein 10, RNA recognition motif 2 [IPR034992]", "RNA-binding protein 5, RNA recognition motif 1 [IPR034991]", "RNA-binding protein 5, RNA recognition motif 2 [IPR034993]", "RNA-binding protein Musashi homologue, RNA recognition motif 1 [IPR034130]", "RNA-binding protein Musashi homologue, RNA recognition motif 2 [IPR034126]", "RNA-polymerase II-associated protein 3-like, C-terminal domain [IPR025986]", "RNA-recognition motif (RRM) Nup35-type domain [IPR007846]", "RNPS1, RNA recognition motif [IPR034201]", "RNase L inhibitor RLI-like, possible metal-binding domain [IPR007209]", "ROCK, Rho binding domain [IPR015008]", "ROK, N-terminal [IPR012987]", "RPN1, N-terminal [IPR040892]", "RPN13, DEUBAD domain [IPR032368]", "RQC domain [IPR018982]", "RUN domain [IPR004012]", "RZZ complex, subunit KNTC1/ROD, C-terminal [IPR019527]", "Rab geranylgeranyltransferase, alpha subunit, insert-domain [IPR009087]", "Rab-GTPase-TBC domain [IPR000195]", "Rab-binding domain FIP-RBD [IPR019018]", "Rab3-GAP regulatory subunit, N-terminal [IPR032839]", "Rab3GAP catalytic subunit, C-terminal [IPR045698]", "Rab3GAP catalytic subunit, conserved domain [IPR026147]", "Rab3GAP regulatory subunit, C-terminal [IPR029257]", "Rad21/Rec8-like protein, C-terminal, eukaryotic [IPR006909]", "Rad21/Rec8-like protein, N-terminal [IPR006910]", "Rad50, ATP-binding cassette domain [IPR045171]", "Rad50/SbcC-type AAA domain [IPR038729]", "Radical SAM [IPR007197]", "Raly, RNA recognition motif [IPR034502]", "Ran binding domain [IPR000156]", "Ran binding protein 9/10, SPRY domain [IPR035782]", "Ran-GTPase activating protein 1, C-terminal [IPR009109]", "Ran-specific GTPase-activating protein 1, Ran-binding domain [IPR045256]", "Rap/Ran-GAP domain [IPR000331]", "Ras GTPase-activating domain [IPR001936]", "Ras-associating (RA) domain [IPR000159]", "RasGAP protein, C-terminal [IPR000593]", "RecF/RecN/SMC, N-terminal [IPR003395]", "RecQ helicase-like 5 [IPR010716]", "Redoxin [IPR013740]", "Replication factor A, C-terminal [IPR013955]", "Replication factor C, C-terminal [IPR013748]", "Replication factor-A protein 1, N-terminal [IPR007199]", "Replication protein A, OB domain [IPR031657]", "Reticulon [IPR003388]", "Rho GTPase-binding/formin homology 3 (GBD/FH3) domain [IPR014768]", "Rho-associated protein kinase 2, HR1 domain [IPR037311]", "Rhodanese-like domain [IPR001763]", "Ribonuclease H1, N-terminal [IPR011320]", "Ribonuclease HII/HIII domain [IPR024567]", "Ribonuclease II/R [IPR001900]", "Ribonuclease, PIN domain [IPR033411]", "Ribonucleoprotein PTB-binding 1, RNA recognition motif 1 [IPR034633]", "Ribonucleotide reductase large subunit, C-terminal [IPR000788]", "Ribonucleotide reductase large subunit, N-terminal [IPR013509]", "Ribonucleotide reductase, class I , alpha subunit [IPR013346]", "Ribose-phosphate pyrophosphokinase, N-terminal domain [IPR029099]", "Ribosomal L28e/Mak16 [IPR029004]", "Ribosomal Protein L6, KOW domain [IPR041997]", "Ribosomal Proteins L2, RNA binding domain [IPR022666]", "Ribosomal RNA adenine methylase transferase, N-terminal [IPR020598]", "Ribosomal RNA methyltransferase FtsJ domain [IPR002877]", "Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381 [IPR024576]", "Ribosomal RNA methyltransferase, Spb1, C-terminal [IPR012920]", "Ribosomal RNA small subunit methyltransferase F, N-terminal [IPR031341]", "Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain [IPR029190]", "Ribosomal RNA-processing protein 7, C-terminal domain [IPR024326]", "Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906]", "Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A [IPR023573]", "Ribosomal protein L10e/L16 [IPR016180]", "Ribosomal protein L11, C-terminal [IPR020783]", "Ribosomal protein L11, N-terminal [IPR020784]", "Ribosomal protein L14, KOW motif [IPR041985]", "Ribosomal protein L14e domain [IPR002784]", "Ribosomal protein L18e/L15P [IPR021131]", "Ribosomal protein L19, eukaryotic [IPR033935]", "Ribosomal protein L19/L19e [IPR000196]", "Ribosomal protein L2, C-terminal [IPR022669]", "Ribosomal protein L23/L25, N-terminal [IPR005633]", "Ribosomal protein L26/L24, KOW domain [IPR041988]", "Ribosomal protein L30, N-terminal [IPR012988]", "Ribosomal protein L30, ferredoxin-like fold domain [IPR016082]", "Ribosomal protein L46, N-terminal [IPR021757]", "Ribosomal protein L5 eukaryotic, C-terminal [IPR025607]", "Ribosomal protein L5, C-terminal [IPR031309]", "Ribosomal protein L5, N-terminal [IPR031310]", "Ribosomal protein L6, N-terminal [IPR005568]", "Ribosomal protein L6, alpha-beta domain [IPR020040]", "Ribosomal protein L7, eukaryotic/archaeal [IPR035808]", "Ribosomal protein L7/L12, C-terminal [IPR013823]", "Ribosomal protein L7/L12, oligomerisation [IPR008932]", "Ribosomal protein L7Ae/L30e/S12e/Gadd45 [IPR004038]", "Ribosomal protein L9, N-terminal [IPR020070]", "Ribosomal protein S10 domain [IPR027486]", "Ribosomal protein S13/S15, N-terminal [IPR012606]", "Ribosomal protein S23/S25, mitochondrial [IPR023611]", "Ribosomal protein S24/S35, mitochondrial, conserved domain [IPR019349]", "Ribosomal protein S3, C-terminal [IPR001351]", "Ribosomal protein S4, KOW domain [IPR041982]", "Ribosomal protein S4/S9, N-terminal [IPR001912]", "Ribosomal protein S4e, N-terminal [IPR013843]", "Ribosomal protein S4e, central region [IPR013845]", "Ribosomal protein S5, C-terminal [IPR005324]", "Ribosomal protein S5, N-terminal [IPR013810]", "Ribosomal protein S6 kinase alpha-3, C-terminal catalytic domain [IPR041905]", "Ribosomal protein S7 domain [IPR023798]", "Ribosomal protein/NADH dehydrogenase domain [IPR007741]", "Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034]", "Ribosome biogenesis protein Bms1, N-terminal [IPR037875]", "Ribosome maturation protein Sdo1/SBDS, C-terminal [IPR018978]", "Ribosome maturation protein Sdo1/SBDS, N-terminal [IPR019783]", "Ribosome receptor lysine/proline rich [IPR007794]", "Ribosome recycling factor domain [IPR023584]", "Ribosome-associated complex head domain [IPR032003]", "Ricin B, lectin domain [IPR000772]", "Roadblock/LAMTOR2 domain [IPR004942]", "Rpn11/EIF3F, C-terminal [IPR024969]", "Rpn13/ADRM1, Pru domain [IPR044868]", "RrmJ-type ribose 2-O-methyltransferase domain [IPR025816]", "Rrp40, S1 domain [IPR037319]", "Rrp44-like cold shock domain [IPR033771]", "Rrp7, RRM-like N-terminal domain [IPR040447]", "Rrp7A, RNA recognition motif [IPR034890]", "RuvB-like, AAA-lid domain [IPR041048]", "S-adenosyl-L-homocysteine hydrolase, NAD binding domain [IPR015878]", "S-adenosylmethionine synthetase, C-terminal [IPR022630]", "S-adenosylmethionine synthetase, N-terminal [IPR022628]", "S-adenosylmethionine synthetase, central domain [IPR022629]", "S1 domain [IPR003029]", "S1-like RNA binding domain [IPR025223]", "S100/CaBP-9k-type, calcium binding, subdomain [IPR013787]", "SAB domain [IPR007477]", "SAC domain [IPR002013]", "SAF domain [IPR013974]", "SAICAR synthetase/ADE2, N-terminal [IPR028923]", "SAM-dependent methyltransferase RsmB/NOP2-type [IPR001678]", "SANT domain [IPR017884]", "SANT/Myb domain [IPR001005]", "SAP domain [IPR003034]", "SART3, RNA recognition motif 1 [IPR034217]", "SART3, RNA recognition motif 2 [IPR034218]", "SCAF8, RNA recognition motif [IPR034370]", "SCP2 sterol-binding domain [IPR003033]", "SEC23-interacting protein, SAM domain [IPR037603]", "SEP domain [IPR012989]", "SERRATE/Ars2 , C-terminal [IPR007042]", "SERRATE/Ars2, N-terminal [IPR021933]", "SET domain [IPR001214]", "SF3A2 domain [IPR031781]", "SF3A3 domain [IPR031774]", "SF3B4, RNA recognition motif 1 [IPR034158]", "SF3B4, RNA recognition motif 2 [IPR034159]", "SF3B6, RNA recognition motif [IPR034150]", "SGNH hydrolase-type esterase domain [IPR013830]", "SGS domain [IPR007699]", "SGTA, homodimerisation domain [IPR032374]", "SH2 domain [IPR000980]", "SH3 domain [IPR001452]", "SHARP, RNA recognition motif 1 [IPR034172]", "SHARP, RNA recognition motif 2 [IPR034173]", "SHARP, RNA recognition motif 3 [IPR034174]", "SHARP, RNA recognition motif 4 [IPR034175]", "SIS domain [IPR001347]", "SKI-interacting protein SKIP, SNW domain [IPR004015]", "SKP1 component, POZ domain [IPR016073]", "SKP1 component, dimerisation [IPR016072]", "SLC12A transporter, C-terminal [IPR018491]", "SLIDE domain [IPR015195]", "SLIRP, RNA recognition motif [IPR034152]", "SMAP1-like, ArfGAP domain [IPR044732]", "SMARCA1, N-terminal [IPR044755]", "SMARCC, C-terminal [IPR032451]", "SMARCC, N-terminal [IPR032450]", "SMARCC, SWIRM-associated domain [IPR032448]", "SMCs flexible hinge [IPR010935]", "SMYD3, SET domain [IPR044420]", "SNARE-complex protein Syntaxin-18, N-terminal [IPR019529]", "SNF2, N-terminal [IPR000330]", "SNX2, PX domain [IPR037918]", "SNX6, PX domain [IPR042136]", "SNX9, SH3 domain [IPR035558]", "SPF45, RNA recognition motif [IPR034653]", "SPRY domain [IPR003877]", "SPRY-associated [IPR006574]", "SR140, RNA recognition motif [IPR035009]", "SRA-YDG [IPR003105]", "SRCR domain [IPR001190]", "SRCR-like domain [IPR017448]", "SRP9 domain [IPR039432]", "SRSF1, RNA recognition motif 1 [IPR034520]", "SRSF7, RNA recognition motif [IPR034651]", "SRSF9, RNA recognition motif 1 [IPR034503]", "SRSF9, RNA recognition motif 2 [IPR034995]", "SSRP1 domain [IPR024954]", "STAG [IPR013721]", "STAR protein, homodimerisation region [IPR032377]", "START domain [IPR002913]", "STAT transcription factor, DNA-binding [IPR013801]", "STAT transcription factor, all-alpha domain [IPR013800]", "STAT transcription factor, protein interaction [IPR013799]", "STAT3, SH2 domain [IPR035855]", "STI1 domain [IPR041243]", "STRBP, first double-stranded RNA binding domain [IPR044472]", "SUI1 domain [IPR001950]", "SUMO-activating enzyme subunit 2, C-terminal domain [IPR032426]", "SUN domain [IPR012919]", "SUZ-C domain [IPR024642]", "SWAP/Surp [IPR000061]", "SWI/SNF-like complex subunit BAF250, C-terminal [IPR033388]", "SWIB domain [IPR019835]", "SWIB/MDM2 domain [IPR003121]", "SWIRM domain [IPR007526]", "Saccharopine dehydrogenase, NADP binding domain [IPR005097]", "Saccharopine dehydrogenase-like, C-terminal [IPR032095]", "Sam68, tyrosine-rich domain [IPR032335]", "Saposin B type domain [IPR008139]", "Schlafen group 3-like, DNA/RNA helicase domain [IPR018647]", "Schlafen, AlbA_2 domain [IPR007421]", "Sec16, central conserved domain [IPR024340]", "Sec23, C-terminal [IPR037550]", "Sec23/Sec24 beta-sandwich [IPR012990]", "Sec23/Sec24, helical domain [IPR006900]", "Sec23/Sec24, trunk domain [IPR006896]", "Sec24-like, trunk domain [IPR041742]", "Sec63 domain [IPR004179]", "Sec7 domain [IPR000904]", "Second polo-box domain [IPR033695]", "Sedolisin domain [IPR030400]", "Senescence/spartin-associated, C-terminal [IPR009686]", "Sentrin-specific protease 3/5, conserved domain [IPR045577]", "Septin-type guanine nucleotide-binding (G) domain [IPR030379]", "Sequestosome-1, PB1 domain [IPR034866]", "Sequestosome-1, UBA domain [IPR033741]", "Serine aminopeptidase, S33 [IPR022742]", "Serine hydroxymethyltransferase-like domain [IPR039429]", "Serine-tRNA ligase catalytic core domain [IPR033729]", "Serine-tRNA synthetase, type1, N-terminal [IPR015866]", "Serine-threonine protein phosphatase, N-terminal [IPR031675]", "Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245]", "Serine/arginine-rich splicing factor SRSF4-like, RNA recognition motif 1 [IPR035585]", "Serine/threonine-protein PRP4, catalytic domain [IPR044092]", "Serine/threonine-protein kinase N, C2 domain [IPR037784]", "Serine/threonine-protein kinase N, first HR1 domain [IPR037313]", "Serine/threonine-protein kinase Nek9, catalytic domain [IPR042767]", "Serine/threonine-protein kinase Rio2 [IPR030484]", "Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase [IPR006186]", "Serpin H1, serpin domain [IPR033830]", "Serpin domain [IPR023796]", "Siah interacting protein, N-terminal [IPR015120]", "Sialidase [IPR011040]", "Signal recognition particle SRP54, helical bundle [IPR013822]", "Signal recognition particle receptor, alpha subunit, N-terminal [IPR007222]", "Signal recognition particle subunit SRP68, RNA-binding domain [IPR034652]", "Signal recognition particle, SRP54 subunit, GTPase domain [IPR000897]", "Signal recognition particle, SRP54 subunit, M-domain [IPR004125]", "Signal recognition particle, SRP72 subunit, RNA-binding [IPR013699]", "Sin3, C-terminal [IPR031693]", "Sirtuin family, catalytic core domain [IPR026590]", "Sister chromatid cohesion C-terminal domain [IPR024986]", "Ski2, N-terminal domain [IPR040801]", "Small G protein signalling modulator 1/2, Rab-binding domain [IPR021935]", "Small GTP-binding protein domain [IPR005225]", "Small nuclear ribonucleoprotein D1 [IPR034102]", "Small-subunit processome, Utp12 [IPR007148]", "Small-subunit processome, Utp13 [IPR013934]", "Small-subunit processome, Utp21 [IPR007319]", "Smc1, ATP-binding cassette domain [IPR028468]", "Smc2, ATP-binding cassette domain [IPR027120]", "Snf2, ATP coupling domain [IPR029295]", "Snu114, GTP-binding domain [IPR044121]", "Sof1-like protein [IPR007287]", "Solute carrier family 3 member 2, N-terminal domain [IPR031984]", "Sortilin, C-terminal [IPR031777]", "Sortilin, N-terminal [IPR031778]", "Sorting Nexin 1, PX domain [IPR034901]", "Sorting nexin Vps5-like, C-terminal [IPR015404]", "Sorting nexin protein, WASP-binding domain [IPR019497]", "Sorting nexin, N-terminal [IPR005329]", "Sorting nexin-9, BAR domain [IPR037425]", "Sorting nexin-9, PX domain [IPR037426]", "Spen paralogue and orthologue SPOC, C-terminal [IPR012921]", "Spen paralogue/orthologue C-terminal, metazoa [IPR010912]", "Spermidine synthase, tetramerisation domain [IPR035246]", "Splicing factor 1, helix-hairpin domain [IPR032570]", "Splicing factor 3A subunit 1, conserved domain [IPR022030]", "Splicing factor 3A subunit 1, ubiquitin domain [IPR035563]", "Splicing factor 3B subunit 1 [IPR015016]", "Splicing factor ELAV/Hu, RNA recognition motif 1 [IPR034775]", "Splicing factor RBM39, linker [IPR029123]", "Splicing factor SF3a60 /Prp9 subunit, C-terminal [IPR024598]", "Splicing factor SF3a60 binding domain [IPR021966]", "Spt5 C-terminal domain [IPR024945]", "Spt5 transcription elongation factor, N-terminal [IPR022581]", "Spt5, KOW domain repeat 1 [IPR041973]", "Spt5, KOW domain repeat 2 [IPR041975]", "Spt5, KOW domain repeat 3 [IPR041976]", "Spt5, KOW domain repeat 4 [IPR041977]", "Spt5, KOW domain repeat 5 [IPR041978]", "Spt5, KOW domain repeat 6 [IPR041980]", "Spt6 acidic, N-terminal domain [IPR028083]", "Spt6, SH2 domain [IPR035420]", "Spt6, SH2 domain, C terminus [IPR035018]", "Spt6, SH2 domain, N terminus [IPR035019]", "Squalene cyclase, C-terminal [IPR032696]", "Squalene cyclase, N-terminal [IPR032697]", "Squalene epoxidase [IPR013698]", "Srp40, C-terminal [IPR007718]", "StAR-related lipid transfer protein 3, C-terminal [IPR029867]", "Staphylococcal nuclease (SNase-like), OB-fold [IPR016071]", "Staufen 1, third double-stranded RNA binding domain [IPR044475]", "Staufen 2, first double-stranded RNA binding domain [IPR044476]", "Staufen 2, fourth double-stranded RNA binding domain [IPR044474]", "Staufen 2, second double-stranded RNA binding domain [IPR044464]", "Staufen 2, third double-stranded RNA binding domain [IPR044473]", "Staufen, C-terminal [IPR032478]", "Steadiness box (SB) domain [IPR017916]", "Sterile alpha motif domain [IPR001660]", "Sterol-sensing domain [IPR000731]", "Striatin, N-terminal [IPR013258]", "Strictosidine synthase, conserved region [IPR018119]", "Stromalin conservative domain [IPR020839]", "Structural maintenance of chromosomes 3, ABC domain, eukaryotic [IPR041741]", "Structural maintenance of chromosomes 4, ABC domain, eukaryotic [IPR041738]", "Succinate dehydogenase/fumarate reductase N-terminal [IPR025192]", "Sulfatase, N-terminal [IPR000917]", "Sulfhydryl oxidase, Trx-like domain [IPR041269]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain [IPR040986]", "Sulphate adenylyltransferase [IPR002650]", "Sulphate adenylyltransferase catalytic domain [IPR024951]", "Suppressor of forked [IPR008847]", "Suppressor of white apricot, N-terminal domain [IPR019147]", "Survival motor neuron [IPR010304]", "Sushi/SCR/CCP domain [IPR000436]", "Suv3, C-terminal domain 1 [IPR041082]", "Suv3, DEXQ-box helicase domain [IPR044774]", "Suv3, N-terminal [IPR041453]", "Symplekin C-terminal [IPR022075]", "Symplekin/Pta1, N-terminal [IPR032460]", "Synaptic functional regulator FMRP, KH0 domain [IPR040472]", "Synaptotagmin, SMP domain [IPR039010]", "Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468]", "Syntaxin, N-terminal domain [IPR006011]", "Syntaxin-8, SNARE domain [IPR041875]", "TAP C-terminal (TAP-C) domain [IPR005637]", "TAR DNA-binding protein 43, N-terminal [IPR041105]", "TATA box binding protein associated factor (TAF) [IPR004823]", "TATA-binding protein interacting (TIP20) [IPR013932]", "TBCE, ubiquitin-like (Ubl) domain [IPR044079]", "TCB1D9/TCB1D9B, PH-GRAM domain 1 [IPR036014]", "TCB1D9/TCB1D9B, PH-GRAM domain 2 [IPR036017]", "TFG box [IPR025768]", "TFG, PB1 domain [IPR034857]", "TFIIEalpha/SarR/Rpc3 HTH domain [IPR024550]", "TGS [IPR004095]", "THIF-type NAD/FAD binding fold [IPR000594]", "THO complex subunit 2, N-terminal domain [IPR032302]", "THO complex, subunitTHOC2, C-terminal [IPR021418]", "THO complex, subunitTHOC2, N-terminal [IPR021726]", "THUMP domain [IPR004114]", "TIA-1, RNA recognition motif 2 [IPR034830]", "TIA-1, RNA recognition motif 3 [IPR034832]", "TIAR, RNA recognition motif 1 [IPR034492]", "TIAR, RNA recognition motif 2 [IPR034494]", "TIAR, RNA recognition motif 3 [IPR034496]", "TIF1-beta, RING finger, HC subclass [IPR042713]", "TIP49, P-loop domain [IPR010339]", "TOG domain [IPR034085]", "TOPK, catalytic domain [IPR041989]", "TOPRIM domain [IPR006171]", "TPX2 central domain [IPR027330]", "TPX2, C-terminal [IPR027329]", "TRAM domain [IPR002792]", "TRAM/LAG1/CLN8 homology domain [IPR006634]", "TRAM1-like protein [IPR013599]", "TRASH domain [IPR011017]", "TRIAD supradomain [IPR044066]", "TRIM25, PRY/SPRY domain [IPR042753]", "TROVE domain [IPR008858]", "TUTase nucleotidyltransferase domain [IPR045100]", "Talin, N-terminal F0 domain [IPR032425]", "Talin, central [IPR015224]", "Talin-1/2, rod-segment [IPR037438]", "Tankyrase 1-binding protein, C-terminal [IPR032764]", "Target SNARE coiled-coil homology domain [IPR000727]", "Telomere length regulation protein, conserved domain [IPR019337]", "Telomere-associated protein Rif1, N-terminal [IPR022031]", "Tensin phosphatase, C2 domain [IPR014020]", "Tensin-type phosphatase domain [IPR029023]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain [IPR020631]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain [IPR020630]", "Tetratricopeptide repeat-like domain [IPR018704]", "Tetratricopeptide, SHNi-TPR domain [IPR019544]", "Tfc3, extended winged-helix domain [IPR035625]", "Thg1 C-terminal domain [IPR025845]", "Thiamine pyrophosphate enzyme, C-terminal TPP-binding [IPR011766]", "Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain [IPR012001]", "Thiamine pyrophosphate enzyme, central domain [IPR012000]", "Thioesterase [IPR001031]", "Thioesterase domain [IPR006683]", "Thiolase, C-terminal [IPR020617]", "Thiolase, N-terminal [IPR020616]", "Thioredoxin domain [IPR013766]", "Thioredoxin domain-containing protein 17-like domain [IPR010357]", "Thioredoxin-like fold [IPR012336]", "Thioredoxin-related transmembrane protein 2, thioredoxin domain [IPR037463]", "Threonine-tRNA ligase catalytic core domain [IPR033728]", "Threonyl/alanyl tRNA synthetase, SAD [IPR012947]", "Thymidylate kinase-like domain [IPR039430]", "Thymidylate synthase/dCMP hydroxymethylase domain [IPR023451]", "Tim10-like [IPR004217]", "Tim44-like domain [IPR007379]", "Timeless, C-terminal [IPR007725]", "Timeless, N-terminal [IPR006906]", "Toll-interacting protein, C2 domain [IPR037301]", "Toll-interacting protein, CUE domain [IPR041799]", "TopBP1, first BRCT domain [IPR044737]", "Topoisomerase I C-terminal domain [IPR025834]", "Trafficking protein particle complex subunit 11 [IPR021773]", "Trafficking protein particle complex subunit 11, C-terminal [IPR025876]", "Trans-isoprenyl diphosphate synthases, head-to-head [IPR033904]", "Transcription elongation factor S-II, central domain [IPR003618]", "Transcription elongation factor Spt6, YqgF domain [IPR028231]", "Transcription elongation factor Spt6, helix-hairpin-helix motif [IPR032706]", "Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type [IPR003617]", "Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958]", "Transcription factor IIIC subunit 5, HTH domain [IPR019136]", "Transcription factor IIIC subunit Tfc1/Sfc1, triple barrel domain [IPR041499]", "Transcription factor IIIC, 90kDa subunit, N-terminal [IPR024761]", "Transcription factor IIIC, putative zinc-finger [IPR024764]", "Transcription factor IIS, N-terminal [IPR017923]", "Transcription factor TFE/TFIIEalpha HTH domain [IPR017919]", "Transcription factor TFIIE alpha subunit, C-terminal [IPR021600]", "Transcription initiation factor IIE subunit alpha, N-terminal [IPR002853]", "Transcription termination and cleavage factor, C-terminal domain [IPR026896]", "Transcriptional coactivator p15 (PC4), C-terminal [IPR003173]", "Transcriptional repressor p66, coiled-coil MBD2-interaction domain [IPR032346]", "Transferrin receptor protein 1/2, PA domain [IPR037324]", "Transferrin receptor-like, dimerisation domain [IPR007365]", "Transketolase, C-terminal domain [IPR033248]", "Transketolase, N-terminal [IPR005474]", "Transketolase-like, pyrimidine-binding domain [IPR005475]", "Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038]", "Translation elongation factor EFG/EF2, domain IV [IPR005517]", "Translation elongation factor EFTs/EF1B, dimerisation [IPR014039]", "Translation elongation factor EFTu-like, domain 2 [IPR004161]", "Translation elongation factor EFTu/EF1A, C-terminal [IPR004160]", "Translation elongation factor, IF5A C-terminal [IPR020189]", "Translation initiation factor IF- 2, domain 3 [IPR023115]", "Translation initiation factor IF-2, domain II [IPR044145]", "Translation initiation factor IF2/IF5 domain [IPR002735]", "Translation initiation factor eIF-2B subunit epsilon, N-terminal [IPR035543]", "Translation initiation factor eIF-2B subunit epsilon, W2 domain [IPR044123]", "Translation initiation factor, beta propellor-like domain [IPR013979]", "Translational (tr)-type GTP-binding domain [IPR000795]", "Translationally controlled tumour protein (TCTP) domain [IPR034737]", "Translocon Sec61/SecY, plug domain [IPR019561]", "Transmembrane protein 201, C-terminal [IPR018861]", "Treacle protein domain [IPR003993]", "Tripeptidyl-peptidase II domain [IPR034051]", "TrmE-type guanine nucleotide-binding domain [IPR031168]", "Tuberin, N-terminal [IPR024584]", "Tuberin-type domain [IPR018515]", "Tubulin binding cofactor C-like domain [IPR012945]", "Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]", "Tubulin/FtsZ, GTPase domain [IPR003008]", "Tudor domain [IPR002999]", "Tumour suppressor p53-binding protein-1 Tudor domain [IPR015125]", "Tyrosine-protein kinase BAZ1B, bromodomain [IPR037375]", "Tyrosine-protein kinase ephrin type A/B receptor-like [IPR011641]", "Tyrosine-protein kinase, catalytic domain [IPR020635]", "Tyrosine-specific protein phosphatase, PTPase domain [IPR000242]", "Tyrosine-specific protein phosphatases domain [IPR000387]", "U-box domain [IPR003613]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 1 [IPR034407]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 2 [IPR034409]", "U1 small nuclear ribonucleoprotein of 70kDa N-terminal [IPR022023]", "U1-C, C2H2-type zinc finger [IPR013085]", "U2A'/phosphoprotein 32 family A, C-terminal [IPR003603]", "U3 small nucleolar RNA-associated protein 10, N-terminal [IPR022125]", "U3 small nucleolar RNA-associated protein 15, C-terminal [IPR018983]", "UAS [IPR006577]", "UBX domain [IPR001012]", "UDP-glucose/GDP-mannose dehydrogenase, C-terminal [IPR014027]", "UDP-glucose/GDP-mannose dehydrogenase, N-terminal [IPR001732]", "UDP-glucose/GDP-mannose dehydrogenase, dimerisation [IPR014026]", "UDP-glucose:glycoprotein glucosyltransferase, thioredoxin-like domain 4 [IPR040525]", "UGGT, thioredoxin-like domain 1 [IPR040693]", "UGGT, thioredoxin-like domain 2 [IPR040694]", "UGGT, thioredoxin-like domain 3 [IPR040692]", "UHRF1, tandem tudor domain [IPR021991]", "UNC-45/Cro1/She4, central domain [IPR024660]", "UPF0113, PUA domain [IPR005155]", "UPF0113, pre-PUA domain [IPR040598]", "UPF3 domain [IPR005120]", "UPF3B, RNA recognition motif-like domain [IPR034979]", "USP8 dimerisation domain [IPR015063]", "UVR domain [IPR001943]", "Ubiquitin E2 variant, N-terminal [IPR008883]", "Ubiquitin carboxyl-terminal hydrolase 47, C-terminal [IPR045578]", "Ubiquitin carboxyl-terminal hydrolase 5, UBA1 domain [IPR041812]", "Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain [IPR024729]", "Ubiquitin carboxyl-terminal hydrolase, C-terminal [IPR029346]", "Ubiquitin conjugation factor E4, core [IPR019474]", "Ubiquitin specific protease domain [IPR028889]", "Ubiquitin system component CUE [IPR003892]", "Ubiquitin-activating enzyme E1, C-terminal [IPR018965]", "Ubiquitin-activating enzyme E1, FCCH domain [IPR032418]", "Ubiquitin-activating enzyme E1, four-helix bundle [IPR032420]", "Ubiquitin-activating enzyme, SCCH domain [IPR019572]", "Ubiquitin-associated domain [IPR015940]", "Ubiquitin-conjugating enzyme E2 [IPR000608]", "Ubiquitin-like domain [IPR000626]", "Ubiquitin-specific peptidase 48 [IPR033841]", "Ubiquitin-specific-processing protease 48, Ubl domain [IPR044743]", "Ubiquitin/SUMO-activating enzyme ubiquitin-like domain [IPR028077]", "Ubiquitinyl hydrolase, variant UBP zinc finger [IPR041432]", "Ubiquitinyl hydrolase-L5 [IPR033837]", "Ulp1 protease family, C-terminal catalytic domain [IPR003653]", "Uncharacterised domain CHP00451 [IPR004521]", "Uncharacterised domain NUC173 [IPR012978]", "Uncharacterised domain NUC202 [IPR012980]", "Uracil-DNA glycosylase-like [IPR005122]", "Uroporphyrinogen decarboxylase (URO-D) [IPR000257]", "Uso1/p115-like vesicle tethering protein, C-terminal [IPR006955]", "VASP tetramerisation [IPR014885]", "VHS domain [IPR002014]", "VIP36, lectin domain [IPR035664]", "VPS10 [IPR006581]", "VPS13, repeated coiled region [IPR031642]", "VPS9 domain [IPR003123]", "Vacuolar protein sorting-associated protein 13, C-terminal [IPR031645]", "Vacuolar protein sorting-associated protein 13, SHR-binding domain [IPR009543]", "Vacuolar protein sorting-associated protein 13, second N-terminal domain [IPR031646]", "Vacuolar protein sorting-associated protein 13-like, N-terminal domain [IPR026854]", "Vacuolar protein sorting-associated protein 4, MIT domain [IPR045253]", "Valyl tRNA synthetase, anticodon-binding domain [IPR033705]", "Vertebrate SNX3, PX domain [IPR042137]", "Vertebrate ubiquitin-conjugating enzyme E2 K, UBA domain [IPR042599]", "Vesicle tethering protein Uso1/P115-like , head domain [IPR006953]", "Vicinal oxygen chelate (VOC) domain [IPR037523]", "Vinculin-binding site-containing domain [IPR015009]", "Virilizer, N-terminal [IPR031801]", "Vitamin B12-dependent methionine synthase, activation domain [IPR004223]", "Vps16, C-terminal [IPR006925]", "Vps16, N-terminal [IPR006926]", "Vps4 oligomerisation, C-terminal [IPR015415]", "Vps53-like, N-terminal [IPR007234]", "W2 domain [IPR003307]", "WAPL domain [IPR012502]", "WD repeat-containing protein 18, C-terminal domain [IPR026987]", "WGR domain [IPR008893]", "WH1/EVH1 domain [IPR000697]", "WH2 domain [IPR003124]", "WHEP-TRS domain [IPR000738]", "WHIM1 domain [IPR028942]", "WHIM2 domain [IPR028941]", "WSTF/Acf1/Cbp146 [IPR013136]", "WW domain [IPR001202]", "WWE domain [IPR004170]", "Wings apart-like protein, C-terminal [IPR022771]", "Wolframin, EF-hand domain [IPR045460]", "Wolframin, OB-fold domain [IPR045461]", "Wolframin, cysteine-rich domain [IPR045400]", "XPC-binding domain [IPR015360]", "XPG, N-terminal [IPR006085]", "XPG-I domain [IPR006086]", "XRCC1, first (central) BRCT domain [IPR045080]", "Xrn1, helical domain [IPR041412]", "YKT6, SNARE motif [IPR045848]", "YTH domain [IPR007275]", "YchF, C-terminal domain [IPR013029]", "YchF, N-terminal [IPR041706]", "YjeF N-terminal domain [IPR004443]", "YqgF/RNase H-like domain [IPR006641]", "Z-binding domain [IPR042371]", "ZAP, helix turn helix N-terminal domain [IPR041360]", "ZAP, zinc finger [IPR040954]", "ZC3H15/TMA46 family, C-terminal [IPR032378]", "ZO-1, SH3 domain [IPR035597]", "ZO-2, SH3 domain [IPR035598]", "ZU5 domain [IPR000906]", "Zasp-like motif [IPR006643]", "Zinc finger C2H2 AKAP95-type [IPR034736]", "Zinc finger C2H2-type [IPR013087]", "Zinc finger C2HC RNF-type [IPR034734]", "Zinc finger, C2H2, LYAR-type [IPR014898]", "Zinc finger, C3HC-like [IPR012935]", "Zinc finger, C3HC4 RING-type [IPR018957]", "Zinc finger, CCCH-type [IPR000571]", "Zinc finger, CCHC-type [IPR001878]", "Zinc finger, CHHC-type [IPR012996]", "Zinc finger, CW-type [IPR011124]", "Zinc finger, CXXC-type [IPR002857]", "Zinc finger, ClpX C4-type [IPR010603]", "Zinc finger, FCS-type [IPR012313]", "Zinc finger, FPG/IleRS-type [IPR010663]", "Zinc finger, FYVE-related [IPR017455]", "Zinc finger, GATA-type [IPR000679]", "Zinc finger, LIM-type [IPR001781]", "Zinc finger, MIZ-type [IPR004181]", "Zinc finger, MYM-type [IPR010507]", "Zinc finger, MYND-type [IPR002893]", "Zinc finger, PARP-type [IPR001510]", "Zinc finger, PHD-finger [IPR019787]", "Zinc finger, PHD-type [IPR001965]", "Zinc finger, RING-CH-type [IPR011016]", "Zinc finger, RING-type [IPR001841]", "Zinc finger, RanBP2-type [IPR001876]", "Zinc finger, Sec23/Sec24-type [IPR006895]", "Zinc finger, TFIIB-type [IPR013137]", "Zinc finger, TFIIS-type [IPR001222]", "Zinc finger, UBP-type [IPR001607]", "Zinc finger, UBR-type [IPR003126]", "Zinc finger, ZZ-type [IPR000433]", "Zinc finger, double-stranded RNA binding [IPR022755]", "Zinc knuckle CX2CX3GHX4C [IPR025829]", "Zinc ribbon, NADH pyrophosphatase [IPR015376]", "Zinc-finger C2H2-type 11 [IPR041697]", "Zinc-ribbon domain [IPR026870]", "Zn-dependent metallo-hydrolase, RNA specificity domain [IPR011108]", "cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117]", "dUTPase, trimeric [IPR033704]", "dUTPase-like [IPR029054]", "eIF3 subunit M, C-terminal helix domain [IPR040750]", "eIF3B, RNA recognition motif [IPR034363]", "eIF3G, RNA recognition motif [IPR034240]", "eIF3h, C-terminal [IPR045810]", "eIF4H, RNA recognition motif [IPR034229]", "eRF1 domain 1/Pelota-like [IPR005140]", "eRF1 domain 2 [IPR005141]", "eRF1 domain 3 [IPR005142]", "hnRNP A0, RNA recognition motif 1 [IPR034801]", "hnRNP A1, RNA recognition motif 1 [IPR034845]", "hnRNP A1, RNA recognition motif 2 [IPR034803]", "hnRNP A2/B1, RNA recognition motif 1 [IPR034486]", "hnRNP A3, RNA recognition motif 1 [IPR034513]", "hnRNP A3, RNA recognition motif 2 [IPR034516]", "hnRNP DL, RNA recognition motif 1 [IPR034847]", "hnRNP-L, RNA recognition motif 1 [IPR035005]", "hnRNP-L, RNA recognition motif 2 [IPR035008]", "hnRNP-L, RNA recognition motif 3 [IPR034816]", "hnRNP-L, RNA recognition motif 4 [IPR034817]", "hnRNPAB, RNA recognition motif 1 [IPR034846]", "hnRNPH3, RNA recognition motif 2 [IPR034970]", "hnRNPH3, RNA recognition motif 3 [IPR034969]", "hnRNPM, RNA recognition motif 3 [IPR034990]", "hnRPLL, RNA recognition motif 1 [IPR034985]", "hnRPLL, RNA recognition motif 2 [IPR034986]", "hnRPLL, RNA recognition motif 3 [IPR034983]", "hnRPLL, RNA recognition motif 4 [IPR034987]", "mRNA splicing factor Cwf21 domain [IPR013170]", "p21 activated kinase binding domain [IPR033923]", "p21-activated kinase 2, catalytic domain [IPR035064]", "p53 transactivation domain [IPR013872]", "p53, DNA-binding domain [IPR011615]", "p53, tetramerisation domain [IPR010991]", "p54nrb, RNA recognition motif 1 [IPR034552]", "rRNA-processing arch domain [IPR025696]", "snRNP70, RNA recognition motif [IPR034143]", "tRNA methyltransferase TRM10-type domain [IPR028564]", "tRNA methyltransferase TRMD/TRM10-type domain [IPR016009]", "tRNA nucleotidyltransferase/poly(A) polymerase, RNA and SrmB- binding domain [IPR032828]", "tRNA pseudouridylate synthase B, C-terminal [IPR032819]", "tRNA synthetase, B5-domain [IPR005147]", "tRNA synthetases class I, catalytic domain [IPR032678]", "tRNA(Met) cytidine acetyltransferase TmcA, N-terminal [IPR013562]", "tRNA-binding domain [IPR002547]", "tRNAHis guanylyltransferase catalytic domain [IPR024956]", "tRNase Z endonuclease [IPR027794]", "v-SNARE, coiled-coil homology domain [IPR042855]", "von Willebrand factor, type A [IPR002035]"], "available_proteins": ["AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABHD10", "ABHD12", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN4", "ADAM17", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADRM1", "ADSL", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK2", "AKAP1", "AKAP12", "AKAP13", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC5", "ANK3", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "APLP2", "APMAP", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARMCX3", "ARMT1", "ASAH1", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "ATP6V1H", "ATXN10", "ATXN2L", "AUP1", "BAG6", "BAIAP2", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BIRC6", "BLM", "BLVRA", "BMS1", "BOP1", "BPTF", "BRCA1", "BRD2", "BRIX1", "BROX", "BSG", "BTF3", "BUB1B", "BUD23", "BZW1", "C1orf35", "CACYBP", "CAD", "CALU", "CAMK2D", "CAMK2G", "CAND1", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CARM1", "CARS", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC97", "CD2AP", "CDC23", "CDC34", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CEBPZ", "CECR2", "CELF1", "CENPB", "CEP170", "CERS2", "CFAP20", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHD4", "CHERP", "CHID1", "CHORDC1", "CHRAC1", "CHTF18", "CIAPIN1", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLIC1", "CLINT1", "CLPB", "CLPX", "CLTC", "CLUH", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT3", "CNOT6", "CNPY2", "COA3", "COIL", "COMMD2", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "CORO1B", "CORO1C", "COTL1", "COX2", "COX6C", "CPD", "CPNE1", "CPNE3", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CRKL", "CRYZ", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNBL1", "CTPS1", "CTPS2", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CWF19L1", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYFIP1", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF13", "DCTN1", "DDB1", "DDI2", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DFFA", "DGCR8", "DGUOK", "DHCR24", "DHFR", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIAPH1", "DIAPH3", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNTTIP2", "DOCK7", "DPF2", "DPM1", "DPP9", "DPYSL2", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "ECE1", "ECI2", "ECSIT", "EDC3", "EDC4", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B3", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "EMC1", "EMC7", "EMD", "EML4", "ENAH", "ENO1", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERLIN2", "ERP29", "ERP44", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOSC1", "EXOSC10", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM208A", "FAM49B", "FAM8A1", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FDFT1", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FOXC1", "FOXK1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GARS", "GART", "GATAD2A", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GIGYF2", "GINS4", "GLA", "GLB1", "GLDC", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMPPA", "GMPS", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGB1", "GORASP2", "GOT1", "GOT2", "GPATCH4", "GPD2", "GPI", "GPRASP2", "GPS1", "GRB2", "GRHPR", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF3C1", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDLBP", "HEATR1", "HECTD1", "HELLS", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIC2", "HIF1AN", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOXA10", "HP1BP3", "HPRT1", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA4", "HSPA4L", "HSPB1", "HSPBP1", "HSPH1", "HTRA2", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFT27", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMPDH2", "INA", "INCENP", "INF2", "INTS11", "INTS14", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRGQ", "IRS4", "ISOC1", "ISYNA1", "ITCH", "ITGB1", "IVD", "KARS", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0391", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMTOR2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3BP", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC47", "LSM12", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LYAR", "LYPLA1", "MACF1", "MAGED2", "MAK16", "MAP2K1", "MAPRE1", "MAPRE2", "MARC1", "MARK2", "MARS", "MAT2A", "MATR3", "MBD3", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "METAP2", "METTL13", "MFN1", "MFN2", "MIA3", "MICU1", "MICU2", "MID1", "MINDY3", "MKI67", "MLEC", "MMAB", "MMS19", "MOGS", "MORF4L1", "MOV10", "MPP2", "MPP6", "MPRIP", "MPST", "MRE11", "MRPL11", "MRPL12", "MRPL15", "MRPL2", "MRPL24", "MRPL39", "MRPL44", "MRPL45", "MRPL46", "MRPL48", "MRPL58", "MRPL9", "MRPS23", "MRPS25", "MRPS35", "MRPS5", "MRPS7", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MTA1", "MTA2", "MTAP", "MTBP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MTX3", "MYEF2", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAA40", "NAA50", "NAGK", "NAGLU", "NAMPT", "NANS", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPG", "NCBP1", "NCL", "NCLN", "NCSTN", "NDUFA10", "NDUFA9", "NDUFAF1", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NEMF", "NENF", "NES", "NEU1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC3L", "NOC4L", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NPTN", "NRBP1", "NRDC", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NTPCR", "NUB1", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP35", "NUP50", "NUP54", "NUP62", "NUP98", "NUPL2", "NUTF2", "NVL", "NXF1", "OCIAD1", "OCLN", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OSBP", "OSBPL11", "OSBPL6", "OSBPL9", "OTUB1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARN", "PARP1", "PARP2", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCM1", "PCNA", "PCYOX1", "PDCD11", "PDCD4", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFKL", "PFKM", "PFKP", "PGD", "PGLS", "PGM1", "PGM2", "PGM3", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF6", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIN4", "PIR", "PITHD1", "PITRM1", "PKM", "PKN2", "PLAA", "PLD3", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POP1", "POR", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1R10", "PPP5C", "PQBP1", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREP", "PREPL", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSPC1", "PTBP1", "PTCD1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPN1", "PUF60", "PUM3", "PUS1", "PUS7", "PWP2", "PYCR1", "PYCR2", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RABGGTA", "RAC1", "RAD21", "RAD23B", "RAD50", "RAD51AP1", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM34", "RBM39", "RBM4", "RBM45", "RBM5", "RBM8A", "RBMX", "RCL1", "RCN1", "RCN2", "RCOR1", "RDX", "RECQL", "RECQL5", "REPS1", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIF1", "RIOK2", "RIPK1", "RNASEH2A", "RNF114", "RNF20", "RNF40", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPAP3", "RPF2", "RPL10", "RPL11", "RPL12", "RPL14", "RPL18", "RPL18A", "RPL19", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL30", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPRD1A", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS2", "RPS20", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS9", "RPSA", "RRBP1", "RRM1", "RRP12", "RRP7A", "RSF1", "RTN3", "RTN4", "RTN4IP1", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAR1A", "SARNP", "SARS", "SARS2", "SART3", "SBDS", "SCAF8", "SCCPDH", "SCP2", "SCRIB", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEL1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGTA", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SIN3A", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC18B1", "SLC25A12", "SLC25A13", "SLC25A24", "SLC27A4", "SLC3A2", "SLC6A15", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMU1", "SMYD3", "SNAP29", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX2", "SNX3", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPEN", "SPTAN1", "SPTBN1", "SPTLC1", "SQLE", "SQSTM1", "SRCAP", "SRI", "SRM", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSRP1", "STAG2", "STARD3", "STAT3", "STAU1", "STAU2", "STEAP3", "STIP1", "STOML2", "STRBP", "STRN4", "STUB1", "STX12", "STX18", "STX7", "STX8", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TAF15", "TAGLN2", "TAP1", "TAP2", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCE", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TDP2", "TDRKH", "TECR", "TELO2", "TEX10", "TFAM", "TFG", "TFRC", "THG1L", "THOC1", "THOC2", "THOC3", "THOP1", "THUMPD3", "TIA1", "TIAL1", "TIMELESS", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TKT", "TLN1", "TMED10", "TMED7", "TMED9", "TMEM201", "TMEM205", "TMEM97", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX4", "TNKS1BP1", "TNPO1", "TOE1", "TOLLIP", "TOM1", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOX4", "TP53", "TP53BP1", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRNT1", "TROVE2", "TSC2", "TSFM", "TSG101", "TSR1", "TSTA3", "TTC4", "TTK", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBL5", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UCHL5", "UGDH", "UGGT1", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF3B", "UQCRC1", "UQCRC2", "UROD", "USO1", "USP10", "USP14", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP20", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VCP", "VIM", "VIRMA", "VPS13A", "VPS16", "VPS18", "VPS29", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WDHD1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR43", "WDR46", "WFS1", "WIZ", "XPNPEP1", "XPO1", "XPO5", "XPO7", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YBX1", "YKT6", "YME1L1", "YTHDC1", "YTHDC2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBTB10", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZDHHC20", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZNF148", "ZNF281", "ZNF318", "ZNF326", "ZNF638", "ZNF687", "ZRANB2", "ZYX"], "leading_proteins": ["AARS2", "ACBD3", "ACOT7", "ACTN4", "AIFM1", "AIMP1", "AIP", "AKAP1", "ANKHD1", "ANKRD17", "AP2M1", "AP3S1", "APP", "APRT", "ARCN1", "ARFGAP1", "ASNS", "ATP13A1", "ATP2B1", "BRCA1", "BROX", "BSG", "CALU", "CAPN2", "CBX1", "CBX3", "CDC34", "CLASP1", "CLASP2", "CMTR1", "CNDP2", "CNOT6", "CSE1L", "CSRP2", "CTPS2", "CYB5D2", "DCTN1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC9", "DRG2", "EEF1A2", "EEF1D", "EFL1", "EFTUD2", "EHD1", "EIF2B3", "EIF5", "EIF5B", "EPB41", "EPHA7", "EPRS", "ERCC3", "ERCC6L", "F11R", "FAF2", "FH", "FKBP14", "FKBP7", "FMR1", "FUS", "FXR1", "GALNT1", "GARS", "GFM1", "GFPT1", "GLRX5", "GNL1", "GPATCH4", "GPS1", "GSPT1", "GTPBP1", "GTPBP10", "HBS1L", "HDAC1", "HEXA", "HLA-B", "HLA-C", "HLTF", "HNRNPAB", "HPRT1", "HTRA2", "HUWE1", "ILKAP", "IPO11", "IPO4", "IPO5", "IPO7", "KDM2A", "KMT2A", "KPNA1", "KPNA2", "KPNA4", "LBR", "LEMD3", "LGALS3BP", "LIMA1", "LNPEP", "LTA4H", "MAPRE2", "METAP2", "MFN1", "MPP6", "MSH3", "MSH6", "MTIF2", "MYH9", "NECAP1", "NECTIN2", "NPC2", "NUB1", "NUCB1", "NUCB2", "NUDCD1", "NUDCD2", "P4HA1", "P4HA2", "PAK2", "PDLIM5", "PEPD", "PLOD3", "PNO1", "PPAT", "PQBP1", "PRKAR1A", "PRPF3", "PRPSAP2", "PTGES3", "QKI", "QSOX2", "RANBP1", "RARS2", "RBM10", "RBM26", "RBM27", "RCN2", "RIPK1", "RNF114", "ROCK2", "RPL28", "RPS10", "RPS5", "RUVBL2", "SARS", "SARS2", "SDF4", "SDR39U1", "SEC31A", "SEPHS1", "SEPT2", "SEPT7", "SMARCAD1", "SMN1*", "SMYD3", "SPTLC1", "SQSTM1", "STX12", "STXBP4", "SUPT16H", "SYNGR2", "TAF15", "TARS2", "TBC1D4", "TJP1", "TJP2", "TMED9", "TOP2B", "TRIM26", "TRIM28", "TRIM33", "TSR1", "TSTA3", "TUBB4B", "TUBB6", "TUFM", "TXNDC12", "TXNDC9", "UBA3", "UBR4", "UBR7", "VARS2", "WARS", "XPNPEP1", "YWHAQ"]} \ No newline at end of file diff --git a/interpro_family/advanced/idx2term.json b/interpro_family/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_family/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_family/basic/idx2term.json b/interpro_family/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_family/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_family/consensus.joblib b/interpro_family/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..f80314c6871784d1f7975d24a1f61babdc6dc805 --- /dev/null +++ b/interpro_family/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:da07f342ef21767832a6f7140a8bc67b5c94b62f93e16f95afc7b12e73acd729 +size 575200 diff --git a/interpro_family/df_merge.tsv b/interpro_family/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..dd1ebfd47b9e5d959f2adf722e930f502d75b412 --- /dev/null +++ b/interpro_family/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_family/metrics.json b/interpro_family/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..893f83a0d2aa5a9d37767cdf2efe40615e09f3e7 --- /dev/null +++ b/interpro_family/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2453, + "annotations_size": 1958, + "title": "Average number of proteins per term", + "value": 1.2579162410623084 +} \ No newline at end of file diff --git a/interpro_family/paths.json b/interpro_family/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..13fdc78d76ad08125285254499be655fa2325c88 --- /dev/null +++ b/interpro_family/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_family/fragment/C334/C334_val_log2fc"} \ No newline at end of file diff --git a/interpro_family/result.tsv b/interpro_family/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..663017e2a1781c35cd4b97cef65de0d98958d58e --- /dev/null +++ b/interpro_family/result.tsv @@ -0,0 +1,80 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Amyloidogenic glycoprotein [IPR008155] 0.9885760913912692 2.6753035812734915 0.0074661608491912 0.9999995760240264 0.0168031528077201 2 P05067 1 +CD36 family [IPR002159] 0.9857201142390862 2.6636527400298737 0.0077297311521298 0.999999747943055 0.0171986518134888 2 Q14108 1 +Beta-hexosaminidase [IPR025705] 0.9832721338229296 2.653654598125777 0.0079625286113813 0.9999998407885932 0.0175966490079962 2 P06865 1 +Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678] 0.9714402284781728 2.605177786860294 0.0091826597919495 0.9999999856957228 0.0195218760832108 2 O60830 1 +Ergosterol biosynthesis ERG4/ERG24 [IPR001171] 0.9616483068135456 2.5648678457427954 0.0103215108791778 0.9999999984950978 0.0212508078879393 2 Q9UBM7 1 +V-type ATPase, V0 complex, 116kDa subunit family [IPR002490] 0.9298245614035092 2.4326652332576995 0.0149881511710612 0.999999999999856 0.028492038828095 2 Q93050 1 +ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028] 0.9298245614035092 2.4326652332576995 0.0149881511710612 0.999999999999856 0.028492038828095 2 Q93050 1 +Nucleobindin [IPR040250] 0.9171766625867016 2.379617250469402 0.017330628570765 0.9999999999999988 0.0318324303391725 2 Q02818 1 +Sodium/potassium-transporting ATPase subunit beta [IPR000402] 0.8755609955120367 2.203069076606237 0.0275898803448271 1.0 0.0461651361147496 2 P05026 1 +Peptidase S10, serine carboxypeptidase [IPR001563] 0.9832653061224488 2.1844510853271144 0.0289291178825092 1.0 0.0479620768958113 3 Q9HB40,Q9H3G5 2 +Prolyl 4-hydroxylase [IPR045054] 0.8392492860057148 2.0465855495462457 0.040698794868879 1.0 0.0628952173269654 2 O15460 1 +Nucleosome assembly protein (NAP) [IPR002164] 0.9306122448979588 1.9862834701665395 0.0470018570168875 1.0 0.0707920277223582 3 P55209,Q01105 2 +Flotillin family [IPR027705] 0.8159934720522235 1.945237622652008 0.0517463856800453 1.0 0.0764055096929318 2 O75955 1 +RNA-binding protein 26/27 [IPR045137] 0.810281517747862 1.9202175950962943 0.0548304200323581 1.0 0.0800581375267392 2 Q9P2N5 1 +Transmembrane protein GPR107/GPR108-like [IPR009637] 0.8017135862913158 1.882597090600185 0.0597549909701529 1.0 0.0856517366907462 2 Q5VW38 1 +Microtubule-associated protein RP/EB [IPR027328] 0.7992656058751539 1.8718288634275304 0.061230283699428 1.0 0.0872553824479477 2 Q15555 1 +Translation initiation factor IF2/IF5 [IPR045196] 0.7968176254590006 1.8610521262452229 0.062736815896746 1.0 0.0889262635765339 2 P55010 1 +Peptidyl-tRNA hydrolase, PTH2 [IPR002833] 0.7927376580987358 1.843072238905229 0.0653184639598656 1.0 0.0914832277778375 2 Q9Y3E5 1 +TAF15/EWS/TLS family [IPR034870] 0.892244897959183 1.839694122537653 0.0658131569362514 1.0 0.0920440896010813 3 P35637,Q92804 2 +Histone deacetylase family [IPR000286] 0.7768257853937219 1.7727359328011207 0.0762724739474052 1.0 0.1031363977824719 2 Q13547 1 +Histone deacetylase [IPR003084] 0.7768257853937219 1.7727359328011207 0.0762724739474052 1.0 0.1031363977824719 2 Q13547 1 +Glycosyl transferase, family 35 [IPR000811] 0.7719298245614039 1.7510283358843262 0.0799410292003692 1.0 0.1067698057123622 2 P06737 1 +Glycogen/starch/alpha-glucan phosphorylase [IPR011833] 0.7719298245614039 1.7510283358843262 0.0799410292003692 1.0 0.1067698057123622 2 P06737 1 +CTP synthase [IPR004468] 0.7690738474092269 1.738351998523162 0.0821488092275206 1.0 0.1091971272691686 2 Q9NRF8 1 +P-type ATPase, subfamily IIB [IPR006408] 0.7552019583843375 1.6766463556083295 0.0936116563632827 1.0 0.1209845697421172 2 P20020 1 +Tight junction protein ZO [IPR005417] 0.7384740922072672 1.601967157585206 0.1091628722075119 1.0 0.1358810577128471 2 Q9UDY2 1 +Snf7 family [IPR005024] 0.731538147694826 1.570927448188845 0.1161995020840787 1.0 0.1426449060066621 2 Q9Y3E7 1 +Aminopeptidase N-type [IPR034016] 0.8145608058963384 1.5375923161687246 0.1241483273877324 1.0 0.1492218692603929 4 Q9UIQ6 1 +SCAMP [IPR007273] 0.7996931752909955 1.479969748419069 0.1388813201051872 1.0 0.1628321106382974 3 O15127 1 +Translation initiation factor IF- 2 [IPR015760] 0.7070583435332558 1.4611027774659884 0.1439872381238318 1.0 0.1681139011606814 2 P46199 1 +Peptidase M20 [IPR002933] 0.6972664218686242 1.4170882628559722 0.1564571236935608 1.0 0.1803078564991124 2 Q96KP4 1 +Small GTPase superfamily, ARF type [IPR024156] 0.686658506731952 1.3693787524771852 0.170880912430376 1.0 0.1934016338373851 2 P40616 1 +Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930] 0.7622076817904524 1.353212158742935 0.1759878620205497 1.0 0.198036915997837 6 Q9UIQ6 1 +Peptidase C2, calpain family [IPR022684] 0.6658506731946174 1.2758021665712502 0.202025461510567 1.0 0.2203709491017772 2 P17655 1 +Proteasome B-type subunit [IPR023333] 0.6854238085256057 1.2230245958434698 0.2213204065925895 1.0 0.2400805296998838 7 P49721 1 +Fragile X mental retardation syndrome-related protein [IPR040148] 0.7262478546829623 1.1915312471215571 0.2334450973860358 1.0 0.2525334257910818 3 Q06787 1 +26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 [IPR019585] 0.6372909016727886 1.1477116868403554 0.2510876050001416 1.0 0.2713609013181706 2 Q13098 1 +Proteasome, subunit alpha/beta [IPR001353] 0.5483793494132454 1.1476171761387024 0.2511266359491957 1.0 0.2713609013181706 14 P28072,P49721 2 +Sister chromatid cohesion protein Pds5 [IPR039776] 0.630762953896371 1.1185489872140526 0.2633325966894 1.0 0.2839235816728223 2 Q9NTI5 1 +Fumarate lyase family [IPR000362] 0.6128110975112225 1.0386982243072451 0.298945107265685 1.0 0.3202048796642293 2 P07954 1 +Importin beta family [IPR040122] 0.6798693344222025 1.0188325885602914 0.3082824514961508 1.0 0.3293055319309674 4 Q8TEX9,Q14974,O00410 3 +Septin [IPR016491] 0.651020408163262 0.8998042487799076 0.3682244328944235 1.0 0.3905652435575737 3 Q16181,Q15019 2 +Beta tubulin [IPR002453] 0.647284226753204 0.8953518470013279 0.3705990328579616 1.0 0.3926584990995069 4 Q9BUF5,P68371 2 +Tubulin [IPR000217] 0.6472842267532041 0.8953518470013279 0.3705990328579616 1.0 0.3926584990995069 4 Q9BUF5,P68371 2 +P-type ATPase [IPR001757] 0.6338890394308648 0.8748449833693627 0.3816582575236689 1.0 0.4041573111040257 5 P20020,Q9HD20 2 +cAMP-dependent protein kinase regulatory subunit [IPR012198] 0.5675234598123262 0.8408496680166104 0.4004321582060826 1.0 0.4231225935064812 2 P10644 1 +Adenylate kinase/UMP-CMP kinase [IPR000850] 0.6237074509132184 0.7967947918201885 0.4255702203707314 1.0 0.4482337232307112 3 P00568 1 +14-3-3 protein [IPR000308] 0.599906925792536 0.7512313710685726 0.4525134234476908 1.0 0.4753333063897954 6 P27348 1 +Vinculin/alpha-catenin [IPR006077] 0.5442676458588388 0.7423626724236888 0.4578676291964723 1.0 0.4799276327444822 2 P35221 1 +Ran binding protein RanBP1-like [IPR045255] 0.5928084681487696 0.6951062619995125 0.486988710724535 1.0 0.5096332953493531 4 P43487 1 +Ras GTPase-activating protein-binding protein [IPR039539] 0.5259077927376575 0.6667483985455978 0.5049328583450836 1.0 0.5270034843495063 2 Q13283 1 +Monothiol glutaredoxin-related [IPR004480] 0.522235822113424 0.6518932728205554 0.5144700249499663 1.0 0.5366714485093416 2 Q86SX6 1 +Ribosomal protein S5/S7 [IPR000235] 0.4985720114239117 0.5586668312686626 0.5763891201219409 1.0 0.5999839963842425 2 P46782 1 +GDP dissociation inhibitor [IPR018203] 0.4957160342717251 0.5477387716837628 0.5838712858039077 1.0 0.6064827467395497 2 P50395 1 +Rab GDI protein [IPR000806] 0.4957160342717251 0.5477387716837628 0.5838712858039077 1.0 0.6064827467395497 2 P50395 1 +Ribosomal protein L3 [IPR000597] 0.4887800897592868 0.5215199899447817 0.6020045838370467 1.0 0.6236640080174272 2 P09001 1 +Calponin/LIMCH1 [IPR001997] 0.4777641778865791 0.4808700992874017 0.6306088250918183 1.0 0.6512299997519938 2 Q15417 1 +Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7 [IPR045237] 0.4753161974704221 0.4720116068706815 0.6369185038836456 1.0 0.6570529139115796 2 Q7L2H7 1 +ThiF/MoeB/HesA family [IPR045886] 0.5071268664843234 0.4350045223410287 0.6635591448736249 1.0 0.6823785744026037 5 Q8TBC4 1 +Serine-tRNA ligase, type1 [IPR002317] 0.461036311709507 0.4216990392003851 0.6732447058444033 1.0 0.691575414393199 2 Q9NP81 1 +Alanine-tRNA ligase, eukaryota/bacteria [IPR023033] 0.4606283149734817 0.420297181290826 0.6742683687827462 1.0 0.691575414393199 2 Q5JTZ9 1 +Alanine-tRNA ligase, class IIc [IPR002318] 0.4606283149734817 0.420297181290826 0.6742683687827462 1.0 0.691575414393199 2 Q5JTZ9 1 +Porin, eukaryotic type [IPR001925] 0.4991836734693838 0.3754487550359286 0.7073267510538759 1.0 0.7232092838451639 3 P45880,P21796 2 +Protein phosphatase 2C family [IPR015655] 0.431660546715627 0.3263530009694156 0.7441572923142696 1.0 0.7588854053913229 2 Q9H0C8 1 +Arginine-tRNA ligase [IPR001278] 0.4275805793553642 0.3140684388343496 0.7534690597378884 1.0 0.7675819037288166 2 Q5T160 1 +Aminopeptidase, leukotriene A4 hydrolase-like [IPR034015] 0.4145246838025315 0.2764610776086914 0.7821939506516264 1.0 0.7951899041411654 2 P09960 1 +Transmembrane emp24 domain-containing protein [IPR015720] 0.4594631540919746 0.268819642151539 0.7880684772918114 1.0 0.8007462784314305 3 Q9BVK6 1 +Pre-mRNA-splicing factor Syf1-like [IPR045075] 0.4351020408163207 0.2127585372266961 0.8315153057575184 1.0 0.8434385842794382 3 Q9HCS7,Q9BZJ0 2 +Fimbrin/Plastin [IPR039959] 0.3729090167278656 0.175239908932909 0.8608911266959756 1.0 0.8715743671513547 2 Q14651 1 +Nucleolar, Nop52 [IPR010301] 0.3676050591595245 0.1644832137240363 0.8693507602807724 1.0 0.8796841284908281 2 Q14684 1 +Valine-tRNA ligase [IPR002303] 0.3663810689514462 0.1620710881954683 0.8712498734387328 1.0 0.8809877062373388 2 Q5ST30 1 +Importin subunit alpha [IPR024931] 0.401388321763988 0.1525888666672217 0.8787225052914058 1.0 0.8877908489992635 4 P52294,O00629,P52292 3 +DNA mismatch repair MutS family [IPR045076] 0.3963265306122401 0.1396936362429354 0.8889020546466575 1.0 0.8971495994835852 3 P52701,P20585 2 +RuvB-like [IPR027238] 0.348837209302327 0.1303831672776691 0.8962632834708288 1.0 0.9031824544703464 2 Q9Y230 1 +HAD-superfamily hydrolase, subfamily IIA [IPR006357] 0.3370053039575644 0.1120224859347764 0.9108055775886612 1.0 0.9164220559705027 2 Q9BXW7 1 +Filamin family [IPR044801] 0.3746938775510156 0.107783347468211 0.9141675527228998 1.0 0.9188604046362618 3 Q14315,O75369 2 +Ribosome biogenesis protein Bms1/Tsr1 [IPR039761] 0.3243574051407527 0.0949920141759833 0.9243211700019444 1.0 0.9285894565745548 2 Q2NL82 1 +Clathrin adaptor, mu subunit [IPR001392] 0.2975510204081585 0.0406692397107033 0.9675595844528986 1.0 0.9700366955242066 3 Q96CW1,Q9Y2T2 2 +Small GTPase [IPR001806] 0.2802370788220601 0.0287618638927673 0.977054516492364 1.0 0.9780535497403112 24 Q3YEC7,P84095,P11233,Q969Q5 4 diff --git a/interpro_family/selections.json b/interpro_family/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..7e0a27b5143b107d0953455d14d891bc526452aa --- /dev/null +++ b/interpro_family/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["-alpha-acetyltransferase 35, NatC auxiliary subunit [IPR007244]", "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, eukaryotes [IPR027496]", "1-Cys peroxiredoxin [IPR045020]", "14-3-3 protein [IPR000308]", "14-3-3 theta [IPR042584]", "18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23-like [IPR039769]", "2-amino-3-ketobutyrate coenzyme A ligase [IPR011282]", "2-deoxynucleoside 5-phosphate N-hydrolase 1, DNPH1 [IPR028607]", "2-oxoglutarate dehydrogenase E1 component [IPR011603]", "2-phosphoglycolate phosphatase, eukaryotic [IPR006349]", "26S Proteasome non-ATPase regulatory subunit 1 [IPR035266]", "26S Proteasome non-ATPase regulatory subunit 11 [IPR035295]", "26S Proteasome non-ATPase regulatory subunit 12 [IPR035297]", "26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4 [IPR040134]", "26S Proteasome non-ATPase regulatory subunit 13 [IPR035298]", "26S Proteasome non-ATPase regulatory subunit 14 [IPR035299]", "26S Proteasome non-ATPase regulatory subunit 6 [IPR035268]", "26S Proteasome non-ATPase regulatory subunit 7/8 [IPR033858]", "26S Proteasome regulatory subunit 4 [IPR035244]", "26S Proteasome regulatory subunit 6A [IPR035254]", "26S Proteasome regulatory subunit 6B [IPR035256]", "26S Proteasome regulatory subunit 7 [IPR035245]", "26S proteasome non-ATPase regulatory subunit 10-like [IPR039334]", "26S proteasome non-ATPase regulatory subunit 3 [IPR035267]", "26S proteasome non-ATPase regulatory subunit Rpn12 [IPR006746]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit [IPR016643]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit [IPR016642]", "26S proteasome regulatory subunit 10B [IPR035263]", "26S proteasome regulatory subunit P45-like [IPR005937]", "26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 [IPR019585]", "28S ribosomal protein S25, mitochondrial [IPR040049]", "28S ribosomal protein S27, mitochondrial [IPR019266]", "3'-5' RNA helicase YTHDC2-like [IPR031083]", "3-hydroxyacyl-CoA dehydrogenase [IPR022694]", "3-hydroxyisobutyrate dehydrogenase [IPR011548]", "3-hydroxyisobutyrate dehydrogenase-related [IPR015815]", "3-ketodihydrosphingosine reductase KDSR-like [IPR045022]", "3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase [IPR039357]", "39S ribosomal protein L46, mitochondrial [IPR040008]", "40S Ribosomal protein S10 [IPR037447]", "40S ribosomal protein S1/3, eukaryotes [IPR027500]", "40S ribosomal protein SA [IPR027504]", "4F2 cell-surface antigen heavy chain [IPR042280]", "5'-3' exoribonuclease [IPR027073]", "5'-3' exoribonuclease type 2 [IPR017151]", "5-lipoxygenase-activating protein [IPR001446]", "50S ribosomal protein L18Ae/60S ribosomal protein L20 and L18a [IPR028877]", "6-Phosphogluconolactonase [IPR039104]", "6-phosphogluconate dehydrogenase [IPR006183]", "6-phosphogluconate dehydrogenase, decarboxylating [IPR006113]", "60S acidic ribosomal protein P0 [IPR030670]", "60S ribosomal protein L18a/ L20, eukaryotes [IPR021138]", "60S ribosomal protein L19 [IPR039547]", "60S ribosomal protein L35 [IPR045059]", "60S ribosomal protein L6E [IPR000915]", "60kDa SS-A/Ro ribonucleoprotein [IPR040322]", "A-kinase anchor protein 12 [IPR028540]", "A-kinase anchor protein 13 [IPR028852]", "A-kinase anchor protein 17A [IPR034355]", "A-kinase anchoring protein 95 (AKAP95) [IPR007071]", "AAA ATPase, CDC48 family [IPR005938]", "ABC transporter Tap-like [IPR013305]", "ADF/Cofilin [IPR017904]", "ADP-ribose pyrophosphatase, mitochondrial [IPR039989]", "ADP-ribosylation factor 1-5 [IPR045872]", "ADP-ribosylation factor-like protein 2 [IPR045873]", "ADP-ribosylation factor-like protein 2/3 [IPR044612]", "ADP-ribosylation factor-like protein 6-interacting protein 1 [IPR033301]", "ADP-ribosylation/Crystallin J1 [IPR005502]", "ADP-specific phosphofructokinase/glucokinase [IPR007666]", "ADP/ATP carrier protein, eukaryotic type [IPR002113]", "AH receptor-interacting protein [IPR031208]", "AIP/AIPL1 [IPR039663]", "AP complex subunit beta [IPR026739]", "AP endonuclease 1 [IPR004808]", "AP-1/2/4 complex subunit beta [IPR016342]", "AP-3 complex subunit beta [IPR026740]", "AP-3 complex subunit sigma [IPR027155]", "ATP synthase membrane subunit K [IPR009125]", "ATP synthase, F0 complex, subunit B [IPR013837]", "ATP synthase, F0 complex, subunit B/MI25 [IPR008688]", "ATP synthase, F0 complex, subunit D, mitochondrial [IPR008689]", "ATP synthase, F0 complex, subunit E, mitochondrial [IPR008386]", "ATP synthase, F0 complex, subunit G, mitochondrial [IPR006808]", "ATP synthase, F1 complex, alpha subunit [IPR005294]", "ATP synthase, F1 complex, beta subunit [IPR005722]", "ATP synthase, F1 complex, gamma subunit [IPR000131]", "ATP-binding cassette sub-family C member 4 [IPR030240]", "ATP-citrate synthase [IPR014608]", "ATP-dependent 6-phosphofructokinase [IPR022953]", "ATP-dependent 6-phosphofructokinase, eukaryotic-type [IPR009161]", "ATP-dependent 6-phosphofructokinase, vertebrate-type [IPR041914]", "ATP-dependent Clp protease proteolytic subunit [IPR001907]", "ATP-dependent RNA helicase DHX29 [IPR034730]", "ATP-dependent RNA helicase Ski2-like [IPR016438]", "ATP-dependent helicase Rad3/Chl1-like [IPR013020]", "ATP:cob(I)alamin adenosyltransferase, PduO-type [IPR029499]", "ATP:guanido phosphotransferase [IPR000749]", "ATPase family AAA domain-containing protein 3 [IPR039188]", "ATPase, OSCP/delta subunit [IPR000711]", "ATPase, V0 complex, c/d subunit [IPR002843]", "ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028]", "ATPase, V0 complex, subunit d [IPR016727]", "ATPase, V1 complex, subunit A [IPR005725]", "ATPase, V1 complex, subunit B [IPR005723]", "ATPase, V1 complex, subunit C [IPR004907]", "ATPase, V1 complex, subunit H [IPR004908]", "Acetyl-coenzyme A transporter 1-like [IPR024371]", "Acid ceramidase-like [IPR016699]", "Acidic leucine-rich nuclear phosphoprotein 32 [IPR045081]", "Acireductone dioxygenase ARD family [IPR004313]", "Aconitase, mitochondrial-like [IPR006248]", "Aconitase/Iron-responsive element-binding protein 2 [IPR006249]", "Actin family [IPR004000]", "Actin-related protein 2/3 complex subunit 1 [IPR017383]", "Actin-related protein 2/3 complex subunit 1A [IPR030140]", "Actin-related protein 2/3 complex subunit 1B [IPR030141]", "Actin-related protein 2/3 complex subunit 3 [IPR007204]", "Actin-related protein 2/3 complex subunit 4 [IPR008384]", "Actin-related protein 3 [IPR015623]", "Actin-related protein 6 [IPR030054]", "Activator of 90kDa heat shock protein ATPase-like [IPR039981]", "Activator of Hsp90 ATPase homologue 1-like [IPR013538]", "Active zone protein ELKS [IPR019323]", "Activity-dependent neuroprotector homeobox protein [IPR038861]", "Acyl-CoA desaturase [IPR015876]", "Acyl-CoA oxidase [IPR012258]", "Acyl-coenzyme A thioesterase 13 [IPR039298]", "Acylneuraminate cytidylyltransferase [IPR003329]", "Acyltransferase ChoActase/COT/CPT [IPR000542]", "Adaptor protein complex AP-1, gamma subunit [IPR017107]", "Adaptor protein complex AP-2, alpha subunit [IPR017104]", "Adaptor protein complex AP-3, delta subunit [IPR017105]", "Adaptor protein complex, sigma subunit [IPR016635]", "Adenine phosphoribosyl transferase [IPR005764]", "Adenosine kinase [IPR001805]", "Adenosylhomocysteinase-like [IPR000043]", "Adenylate cyclase-associated CAP [IPR001837]", "Adenylate kinase 2 [IPR028587]", "Adenylate kinase isoenzyme 1 [IPR028582]", "Adenylate kinase isoenzyme 6 [IPR020618]", "Adenylate kinase subfamily [IPR006259]", "Adenylate kinase, isozyme 1/5 [IPR006267]", "Adenylate kinase/UMP-CMP kinase [IPR000850]", "Adenylosuccinate lyase [IPR004769]", "Adenylosuccinate synthetase [IPR001114]", "Adenylosuccinate synthetase isozyme 2, chordates [IPR027529]", "Adenylyl cyclase-associated protein CAP1 [IPR028415]", "Adenylyl-sulfate kinase [IPR002891]", "AdoMet-dependent rRNA methyltransferase Spb1-like [IPR028589]", "Aladin [IPR045139]", "Alanine-tRNA ligase, class IIc [IPR002318]", "Alanine-tRNA ligase, eukaryota/bacteria [IPR023033]", "Alcohol dehydrogenase class III [IPR014183]", "Aldehyde dehydrogenase NAD(P)-dependent [IPR012394]", "Aldehyde dehydrogenase family 7 member A1-like [IPR044638]", "Aldo-keto reductase [IPR020471]", "Aldo-keto reductase family 1 member A1 [IPR044481]", "Alkyldihydroxyacetonephosphate synthase [IPR025650]", "Alpha E-catenin/Alpha T-catenin [IPR030047]", "Alpha crystallin/Small heat shock protein, animal type [IPR001436]", "Alpha-2-macroglobulin receptor-associated protein [IPR038003]", "Alpha-D-phosphohexomutase superfamily [IPR005841]", "Alpha-L-fucosidase, metazoa-type [IPR016286]", "Alpha-N-acetylglucosaminidase [IPR007781]", "Alpha-N-methyltransferase NTM1 [IPR008576]", "Alpha-adducin [IPR027766]", "Alpha-catenin [IPR001033]", "Alpha-internexin [IPR027703]", "Alpha-ketoglutarate-dependent dioxygenase FTO [IPR032868]", "Amidase [IPR000120]", "Amidophosphoribosyltransferase [IPR005854]", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 [IPR042360]", "Aminoacyl-tRNA synthetase, class Ic [IPR002305]", "Aminopeptidase N-type [IPR034016]", "Aminopeptidase, leukotriene A4 hydrolase-like [IPR034015]", "Aminotransferase class IV [IPR001544]", "Aminotransferase class-III [IPR005814]", "AmpG-like permease/Acetyl-coenzyme A transporter 1 [IPR004752]", "Amyloid-beta precursor protein [IPR028866]", "Amyloidogenic glycoprotein [IPR008155]", "Anamorsin [IPR007785]", "Anaphase-promoting complex subunit 1 [IPR024990]", "Anaphase-promoting complex subunit 16 [IPR029641]", "Anaphase-promoting complex subunit 5 [IPR037679]", "Ancient conserved domain protein family [IPR045095]", "Angiomotin [IPR009114]", "Ankycorbin [IPR042420]", "Ankyrin repeat and LEM domain-containing protein 2 [IPR035007]", "Annexin A1 [IPR002388]", "Annexin A11 [IPR008157]", "Annexin A2 [IPR002389]", "Annexin A6 [IPR002393]", "Annexin [IPR001464]", "Antifreeze, type III [IPR006013]", "Antigen peptide transporter 1 [IPR013306]", "Antigen peptide transporter 2 [IPR005293]", "Apolipoprotein L [IPR008405]", "Apoptosis inhibitory 5 [IPR008383]", "Apoptosis regulator, Mcl-1 [IPR013281]", "Arginase [IPR014033]", "Arginine-tRNA ligase [IPR001278]", "Armadillo repeat-containing protein 6 [IPR040104]", "Arsenical pump ATPase, ArsA/GET3 [IPR016300]", "Arsenical pump ATPase, ArsA/GET3, eukaryotic [IPR027542]", "Arylesterase [IPR002640]", "Asparaginase-like 1, metazoa [IPR033844]", "Asparagine synthase, glutamine-hydrolyzing [IPR006426]", "Asparagine-tRNA ligase [IPR004522]", "Asparaginyl endopeptidase [IPR043577]", "Aspartate carbamoyltransferase [IPR002082]", "Aspartate-tRNA ligase, type 1 [IPR004524]", "Aspartate-tRNA synthetase, type 2 [IPR004523]", "Aspartate/ornithine carbamoyltransferase [IPR006130]", "Aspartate/other aminotransferase [IPR000796]", "Aspartyl/Asparaginyl-tRNA synthetase, class IIb [IPR002312]", "Aspartyl/asparaginyl beta-hydroxylase family [IPR039038]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit [IPR004413]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, subunit B /E [IPR017959]", "Ataxin2-like [IPR045117]", "Atypical dual specificity phosphatase, subfamily A [IPR020405]", "B-cell receptor-associated protein 29/31 [IPR008417]", "BBP/SF1 family [IPR031150]", "BCP1 family [IPR025602]", "BLOC-2 complex, Hps6 subunit [IPR017218]", "BRCA1-A complex subunit BRE [IPR010358]", "BRCA1-associated [IPR031099]", "BRI3-binding protein [IPR033367]", "BRISC and BRCA1-A complex member 1 [IPR026126]", "BRO1 domain-containing protein BROX [IPR038898]", "BTB-kelch protein [IPR017096]", "Bacterial/eukaryotic lysine-tRNA ligase, class II [IPR034762]", "Baculoviral IAP repeat-containing protein 6 [IPR022103]", "Band 4.1 protein, chordates [IPR021187]", "Band 4.1-like protein 2 [IPR030546]", "Barrier- to-autointegration factor, BAF [IPR004122]", "Basigin [IPR044157]", "Basigin-like [IPR043204]", "Bcl-2 family [IPR026298]", "Bcl-2-associated transcription factor 1 [IPR026668]", "Bcl2-like [IPR002475]", "Beta tubulin [IPR002453]", "Beta-1,4-glucuronyltransferase 1 [IPR043189]", "Beta-N-acetylglucosaminidase [IPR011496]", "Beta-catenin [IPR013284]", "Beta-catenin-like protein 1 [IPR039678]", "Beta-galactosidase 1-like [IPR026283]", "Beta-hexosaminidase [IPR025705]", "Beta-lactamase HcpB-like [IPR040239]", "Bifunctional purine biosynthesis protein PurH-like [IPR002695]", "Biliverdin reductase A [IPR017094]", "Biotin--acetyl-CoA-carboxylase ligase [IPR004408]", "BolA protein [IPR002634]", "BolA-like protein 2 [IPR045115]", "Brain acid soluble protein 1 [IPR008408]", "Branched-chain amino acid aminotransferase II [IPR005786]", "Branched-chain aminotransferase [IPR033939]", "Breast cancer type 1 susceptibility protein (BRCA1) [IPR011364]", "Bromodomain adjacent to zinc finger domain protein 2A [IPR028940]", "Bystin [IPR007955]", "C-5 cytosine methyltransferase [IPR001525]", "C-terminal binding protein [IPR043322]", "CAAX prenyl protease 1 [IPR027057]", "CCR4-NOT complex, subunit 3/ 5 [IPR012270]", "CCR4-NOT transcription complex subunit 1 [IPR040398]", "CCR4-NOT transcription complex subunit 10 [IPR039740]", "CCR4-NOT transcription complex subunit 7 [IPR039636]", "CCR4-NOT transcription complex subunit 7/8/Pop2 [IPR039637]", "CCR4-NOT transcription complex subunit 9 [IPR007216]", "CD2-associated protein [IPR028445]", "CD36 family [IPR002159]", "CD36/scavenger receptor class B member 1 [IPR005428]", "CDGSH iron-sulfur domain-containing protein 1/2 [IPR045131]", "CDK5 regulatory subunit-associated protein 3 [IPR008491]", "CDP-alcohol phosphatidyltransferase [IPR000462]", "CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote [IPR014387]", "CEBPZ/Mak21-like [IPR040155]", "CHORD domain containing protein [IPR039790]", "CLIP-associating protein 1 [IPR028399]", "CLU domain containing protein [IPR027523]", "COMM domain-containing protein 2 [IPR037354]", "COMPASS component Swd2/WDR82 [IPR037867]", "COP9 Signalosome complex subunit 7A [IPR037757]", "COP9 signalosome complex subunit 1 [IPR033008]", "COP9 signalosome complex subunit 2 [IPR037750]", "COP9 signalosome complex subunit 3 [IPR037753]", "COP9 signalosome complex subunit 4 [IPR037754]", "COP9 signalosome complex subunit 5 [IPR037740]", "COP9 signalosome subunit 6 [IPR033859]", "COP9 signalosome, subunit CSN8 [IPR033205]", "COPII coat assembly protein, Sec16 [IPR024880]", "CPSF6/7 family [IPR034772]", "CTP synthase [IPR004468]", "CXXC motif containing zinc binding protein, eukaryotic [IPR008584]", "CYFIP-related Rac1 interactor [IPR039789]", "Calcium homeostasis endoplasmic reticulum protein [IPR039037]", "Calcium load-activated calcium channel [IPR008559]", "Calcium uptake protein 1/2/3 [IPR039800]", "Calcium-binding mitochondrial carrier protein Aralar2 [IPR029658]", "Calcium-binding protein CAB45 [IPR027240]", "Caldesmon [IPR006017]", "Caldesmon/lymphocyte specific protein [IPR006018]", "Calpain-1 [IPR029643]", "Calpain-2 [IPR029539]", "Calpastatin [IPR026998]", "Calponin-2 [IPR029974]", "Calponin/LIMCH1 [IPR001997]", "Calreticulin [IPR009169]", "Calreticulin/calnexin [IPR001580]", "Calumenin [IPR027239]", "Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 1 [IPR030376]", "Caprin [IPR028816]", "Carbamoyl-phosphate synthase, large subunit [IPR006275]", "Carbamoyl-phosphate synthase, small subunit [IPR006274]", "Carbohydrate sulfotransferase 8-10 [IPR018011]", "Cartilage-associated protein [IPR033212]", "Casein kinase II, regulatory subunit [IPR000704]", "Cat eye syndrome critical region protein 2 [IPR029614]", "Cat eye syndrome critical region protein 5 [IPR029621]", "Catechol O-methyltransferase, eukaryotic [IPR017128]", "Catenin delta-1 [IPR028439]", "Ccdc97-like [IPR018613]", "Cdc37 [IPR004918]", "Cdc42 [IPR037874]", "Cdc73/Parafibromin [IPR007852]", "Cell cycle and apoptosis regulator protein 2 [IPR028811]", "Cell cycle and apoptosis regulator protein [IPR025224]", "Cell division cycle protein 123 [IPR009772]", "Cell division protein borealin [IPR018867]", "Cell growth-regulating nucleolar protein [IPR039999]", "Cell-cycle alteration and expression-elevated protein in tumour [IPR032337]", "Centromere protein I [IPR012485]", "Centrosomal protein of 170kDa [IPR026644]", "Ceroid-lipofuscinosis neuronal protein 5 [IPR026138]", "Cgr1-like [IPR005579]", "Chaperone DnaJ [IPR012724]", "Chaperone DnaK [IPR012725]", "Chaperone tailless complex polypeptide 1 (TCP-1) [IPR017998]", "Chaperonin Cpn60/GroEL [IPR001844]", "Chaperonin Cpn60/GroEL/TCP-1 family [IPR002423]", "Chloride channel ClC-3 [IPR002245]", "Chloride channel, voltage gated [IPR001807]", "Chloride intracellular channel protein 1 [IPR030259]", "Chromatid cohesion factor MAU2 [IPR019440]", "Chromatin assembly factor 1 subunit Cac2/CHAF1B/FAS2 [IPR045145]", "Chromatin-remodeling complex component Sfh1/SNF5 [IPR017393]", "Chromobox protein homologue 3 [IPR038033]", "Chromosome alignment-maintaining phosphoprotein 1 [IPR039330]", "Cilia- and flagella-associated protein 20/CFAP20DC [IPR040441]", "Cip1-interacting zinc finger protein [IPR026811]", "Citrate synthase [IPR002020]", "Citrate synthase, eukaryotic-type [IPR010109]", "Class I-like SAM-dependent O-methyltransferase [IPR002935]", "Clathrin adaptor, mu subunit [IPR001392]", "Clathrin coat assembly protein AP180-like [IPR045192]", "Clathrin interactor 1 [IPR030544]", "Clathrin, heavy chain [IPR016341]", "Cleavage and polyadenylation specificity factor subunit 2 [IPR027075]", "Cleavage and polyadenylation specificity factor subunit 6 [IPR034769]", "Cleavage and polyadenylation specificity factor subunit 7 [IPR034770]", "Cleavage stimulation factor subunit 1-like [IPR044633]", "Cleavage stimulation factor subunit 2 [IPR033105]", "Cleavage/polyadenylation specificity factor subunit 5 [IPR016706]", "Cleft lip and palate transmembrane 1 [IPR008429]", "Cleft lip and palate transmembrane protein 1-like protein [IPR030434]", "Clp protease proteolytic subunit /Translocation-enhancing protein TepA [IPR023562]", "Clp protease, ATP-binding subunit ClpX [IPR004487]", "ClpA/B family [IPR001270]", "Co-chaperone protein p23-like [IPR045250]", "Coactosin-like protein [IPR030502]", "Coatomer alpha subunit [IPR016391]", "Coatomer beta subunit (COPB1) [IPR016460]", "Coatomer beta' subunit (COPB2) [IPR016453]", "Coatomer delta subunit [IPR027059]", "Coatomer gamma subunit [IPR017106]", "Coatomer subunit zeta [IPR039652]", "Cobalamin-dependent methionine synthase [IPR011822]", "Cofilin 1 [IPR027234]", "Cohesin subunit Scc3/SA [IPR039662]", "Coiled-coil domain-containing protein 124/Oxs1 [IPR010422]", "Coiled-coil domain-containing protein 86 [IPR026570]", "Coilin [IPR024822]", "Complex I intermediate-associated protein 30, mitochondrial [IPR039131]", "Condensin complex subunit 2/barren [IPR022816]", "Condensin complex subunit 3 [IPR027165]", "Condensin subunit 1 [IPR007673]", "Condensin subunit 1/Condensin-2 complex subunit D3 [IPR026971]", "Conserved oligomeric Golgi complex subunit 7 [IPR019335]", "Constitutive coactivator of PPAR-gamma [IPR026784]", "Copine [IPR045052]", "Copper chaperone SCO1/SenC [IPR003782]", "Coproporphyrinogen III oxidase, aerobic [IPR001260]", "Core histone macro-H2A [IPR021171]", "Coronin 1B [IPR027340]", "Coronin 1C [IPR027333]", "Coronin [IPR015505]", "Cortactin [IPR015503]", "Cullin [IPR045093]", "Cullin-4B [IPR033044]", "Cullin-associated NEDD8-dissociated protein 1/2 [IPR039852]", "Cwf19-like protein [IPR040194]", "Cyclic nucleotide phosphodiesterase [IPR008431]", "Cyclin-dependent kinase 6 [IPR028788]", "Cyclophilin-RNA interacting protein [IPR035542]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase [IPR024936]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like [IPR044666]", "Cysteine protease ATG4B, metazoa [IPR032916]", "Cysteine-tRNA ligase [IPR015803]", "Cysteinyl-tRNA synthetase/mycothiol ligase [IPR024909]", "Cystinyl aminopeptidase [IPR034017]", "Cytochrome P450 [IPR001128]", "Cytochrome P450, E-class, group IV [IPR002403]", "Cytochrome b-c1 complex subunit 8 [IPR004205]", "Cytochrome b-c1 complex subunit 9 [IPR008027]", "Cytochrome c oxidase assembly factor 3, mitochondrial [IPR041752]", "Cytochrome c oxidase subunit 6C [IPR004204]", "Cytochrome c oxidase subunit IV [IPR013288]", "Cytochrome c oxidase subunit IV family [IPR004203]", "Cytochrome c oxidase subunit VII [IPR039297]", "Cytochrome c oxidase subunit VIIa, metazoa [IPR003177]", "Cytochrome c oxidase subunit VIIc [IPR004202]", "Cytochrome c oxidase, subunit Va/VI [IPR003204]", "Cytochrome c oxidase, subunit Vb [IPR002124]", "Cytochrome c/quinol oxidase subunit II [IPR045187]", "Cytochrome c1 [IPR002326]", "Cytoplasmic FMR1-interacting [IPR008081]", "Cytoplasmic dynein 1 intermediate chain 1/2 [IPR025956]", "Cytoskeleton-associated protein 2 family [IPR026165]", "Cytoskeleton-associated protein 4 [IPR028428]", "Cytosolic Fe-S cluster assembly factor NUBP2/Cfd1, eukaryotes [IPR028600]", "Cytosolic acyl coenzyme A thioester hydrolase [IPR040170]", "Cytosolic nonspecific dipeptidase/DUG1 [IPR017153]", "D-3-phosphoglycerate dehydrogenase [IPR006236]", "DAD/Ost2 [IPR003038]", "DDRGK domain containing protein [IPR019153]", "DDX54/DBP10 family [IPR033517]", "DENR family, eukaryotes [IPR005873]", "DNA (cytosine-5)-methyltransferase 1-like [IPR017198]", "DNA damage-binding protein 1 [IPR031297]", "DNA double-strand break repair protein Mre11 [IPR003701]", "DNA fragmentation factor 45 [IPR017299]", "DNA helicase, ATP-dependent, RecQ type [IPR004589]", "DNA ligase, ATP-dependent [IPR000977]", "DNA mismatch repair Msh2-type [IPR011184]", "DNA mismatch repair MutS family [IPR045076]", "DNA mismatch repair protein Msh2 [IPR032642]", "DNA mismatch repair protein MutS/MSH [IPR017261]", "DNA polymerase V/Myb-binding protein 1A [IPR007015]", "DNA polymerase epsilon catalytic subunit [IPR029703]", "DNA primase large subunit, eukaryotic/archaeal [IPR007238]", "DNA primase, large subunit, eukaryotic [IPR016558]", "DNA primase, small subunit [IPR002755]", "DNA primase, small subunit, eukaryotic/archaeal [IPR014052]", "DNA repair protein Rad50, eukaryotes [IPR004584]", "DNA repair/transcription protein MET18/MMS19 [IPR039920]", "DNA replication licensing factor Mcm2 [IPR008045]", "DNA replication licensing factor Mcm3 [IPR008046]", "DNA replication licensing factor Mcm5 [IPR008048]", "DNA replication licensing factor Mcm6 [IPR008049]", "DNA replication licensing factor Mcm7 [IPR008050]", "DNA topoisomerase I [IPR001631]", "DNA topoisomerase II, eukaryotic-type [IPR001154]", "DNA topoisomerase II-beta [IPR028467]", "DNA topoisomerase, type IIA [IPR001241]", "DNA-directed DNA polymerase, family B [IPR006172]", "DNA-directed RNA pol I, largest subunit [IPR015699]", "DNA-directed RNA polymerase I, subunit RPA34.5 [IPR013240]", "DNA-directed RNA polymerase III subunit RPC3 [IPR039748]", "DNA-directed RNA polymerase subunit Rpo5/Rpb5 [IPR014381]", "DNA-directed RNA polymerase, phage-type [IPR002092]", "DNA-directed RNA polymerase, subunit 2 [IPR015712]", "DNA-directed RNA polymerase, subunit beta-prime [IPR045867]", "DNA-directed RNA polymerases I and III subunit AC40 [IPR033901]", "DNA2/NAM7-like helicase [IPR045055]", "DPM1-like [IPR039528]", "Death-inducer obliterator 1 [IPR033082]", "Dedicator of cytokinesis [IPR026791]", "Delta l-pyrroline-5-carboxylate synthetase [IPR005766]", "Delta(24)-sterol reductase [IPR040165]", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase Ech1-like [IPR045002]", "Deoxyhypusine hydroxylase [IPR027517]", "Deoxyhypusine synthase [IPR002773]", "Deoxynucleoside kinase [IPR002624]", "Deoxyuridine triphosphate nucleotidohydrolase [IPR008181]", "Dephospho-CoA kinase [IPR001977]", "Derlin [IPR007599]", "Dermcidin [IPR028130]", "Dermcidin/Lacritin [IPR043557]", "Desmoglein [IPR009123]", "Desmoplakin [IPR028462]", "Desmosomal cadherin [IPR009122]", "Destrin [IPR029924]", "Deubiquitinating enzyme MINDY-3/4 [IPR039785]", "Developmentally regulated GTP-binding protein [IPR045001]", "Dihydrofolate reductase [IPR012259]", "Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component [IPR045257]", "Dihydrolipoamide dehydrogenase [IPR006258]", "Dihydrolipoamide succinyltransferase [IPR006255]", "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex [IPR006257]", "Dihydropyrimidinase-related protein 2 [IPR030615]", "Dihydroxyacetone phosphate acyltransferase [IPR028353]", "Dipeptidyl-peptidase 3 [IPR005317]", "Diphthamide synthesis DHP2 [IPR010014]", "Diphthamide synthesis DPH1/DPH2 [IPR016435]", "Divalent ion tolerance protein, CutA [IPR004323]", "DnaJ homolog subfamily A member 1/2-like [IPR044713]", "DnaJ homolog subfamily C member 8 [IPR042858]", "DnaJ homologue subfamily C member 10 [IPR021170]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48kDa subunit [IPR005013]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1 [IPR008814]", "Drebrin [IPR028438]", "Drebrin-like protein [IPR029923]", "Dynactin subunit 3 [IPR009991]", "Dynactin subunit 4 [IPR008603]", "Dynamin [IPR022812]", "Dynamin-1-like protein [IPR030556]", "Dynamin-2 [IPR027188]", "Dynamin-like 120kDa protein, mitochondrial [IPR033047]", "Dynamitin [IPR028133]", "Dynein 1 light intermediate chain [IPR008467]", "Dynein family light intermediate chain [IPR022780]", "Dynein light chain, type 1/2 [IPR001372]", "Dynein regulator LIS1 [IPR017252]", "Dystrophin/utrophin [IPR035436]", "E3 SUMO-protein ligase Nse2 (Mms21) [IPR026846]", "E3 UFM1-protein ligase 1 [IPR018611]", "E3 ubiquitin ligase Bre1 [IPR013956]", "E3 ubiquitin ligase RBR family [IPR031127]", "E3 ubiquitin ligase UBR4-like [IPR045189]", "E3 ubiquitin-protein ligase ARIH2 [IPR031126]", "E3 ubiquitin-protein ligase CHIP/LubX [IPR045200]", "E3 ubiquitin-protein ligase HECTD1/TRIP12-like [IPR045322]", "E3 ubiquitin-protein ligase RBBP6 family [IPR033489]", "E3 ubiquitin-protein ligase UBR7 [IPR040204]", "E3 ubiquitin-protein ligase listerin [IPR039795]", "E3 ubiquitin-protein ligase, SMURF1 type [IPR024928]", "EB1, Metazoa [IPR027739]", "EB2, vertebrate [IPR027735]", "ECSIT [IPR010418]", "EH domain-containing protein 1/3 [IPR029951]", "ELL/occludin family [IPR031176]", "ELMO domain-containing protein 2 [IPR030724]", "ER lumen protein retaining receptor [IPR000133]", "ER membrane protein complex subunit 1 [IPR026895]", "ER membrane protein complex subunit 2-like [IPR039856]", "ER membrane protein complex subunit 7 [IPR039163]", "ERAP2 aminopeptidase [IPR033528]", "ERG2/sigma1 receptor-like [IPR006716]", "ERp19 [IPR037462]", "Electron transfer flavoprotein alpha subunit/FixB [IPR001308]", "Electron transfer flavoprotein, beta subunit [IPR012255]", "Electron transfer flavoprotein-ubiquinone oxidoreductase [IPR040156]", "Elongation factor G1-like [IPR045044]", "Elongator complex protein 1 [IPR006849]", "Elongator complex protein 2 [IPR037289]", "Elongin B [IPR039049]", "Emerin [IPR035004]", "Endophilin-A [IPR028501]", "Endophilin-B1 [IPR028503]", "Endoplasmic reticulum aninopeptidase 1 [IPR033520]", "Endoplasmic reticulum oxidoreductin 1 [IPR007266]", "Endoplasmic reticulum protein SC65 [IPR033213]", "Endoplasmic reticulum resident protein 29 [IPR016855]", "Endoplasmic reticulum vesicle transporter [IPR045888]", "Endosulphine [IPR006760]", "Endothelin-converting enzyme 1 [IPR029734]", "Enhancer of mRNA-decapping protein 4-like [IPR045152]", "Enhancer of rudimentary [IPR000781]", "Enolase [IPR000941]", "Enoyl-CoA hydratase/isomerase [IPR001753]", "Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type [IPR032259]", "Ephrin receptor type-A /type-B [IPR016257]", "Epimerase family protein SDR39U1 [IPR010099]", "Epoxide hydrolase [IPR016292]", "Epoxide hydrolase-like [IPR000639]", "Ergosterol biosynthesis ERG4/ERG24 [IPR001171]", "Erlin1/2 [IPR033294]", "Esterase-like [IPR000801]", "Eukaryotic porin/Tom40 [IPR027246]", "Eukaryotic rRNA processing [IPR008610]", "Eukaryotic translation elongation factor 1 epsilon-1 [IPR042450]", "Eukaryotic translation initiation factor 3 subunit A [IPR027512]", "Eukaryotic translation initiation factor 3 subunit B [IPR011400]", "Eukaryotic translation initiation factor 3 subunit D [IPR007783]", "Eukaryotic translation initiation factor 3 subunit E [IPR016650]", "Eukaryotic translation initiation factor 3 subunit F [IPR027531]", "Eukaryotic translation initiation factor 3 subunit G [IPR017334]", "Eukaryotic translation initiation factor 3 subunit H [IPR027524]", "Eukaryotic translation initiation factor 3 subunit I [IPR027525]", "Eukaryotic translation initiation factor 3 subunit J [IPR013906]", "Eukaryotic translation initiation factor 3 subunit K [IPR009374]", "Eukaryotic translation initiation factor 3 subunit M [IPR027528]", "Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7 [IPR045237]", "Eukaryotic translation initiation factor 4 gamma 1 [IPR037584]", "Eukaryotic translation initiation factor 4 gamma 3 [IPR037585]", "Eukaryotic translation initiation factor 4B [IPR033107]", "Exocyst complex component EXOC2/Sec5 [IPR029175]", "Exocyst complex component EXOC3/Sec6 [IPR010326]", "Exocyst complex component EXOC5/Sec10 [IPR033960]", "Exocyst complex component Exo70 [IPR004140]", "Exocyst complex component Sec10-like [IPR009976]", "Exonuclease 1 [IPR032641]", "Exosome complex RNA-binding protein 1/RRP40/RRP4 [IPR026699]", "Exosome complex component Csl4 [IPR039771]", "Exosome complex exonuclease Rrp6-like [IPR045092]", "Exportin 4/7-like [IPR044189]", "Exportin-1/5 [IPR045065]", "Exportin-5 [IPR040018]", "Exportin-7 [IPR040021]", "Ezrin/radixin/moesin [IPR011174]", "Ezrin/radixin/moesin-like [IPR000798]", "F-actin-capping protein subunit alpha [IPR002189]", "F-actin-capping protein subunit beta [IPR001698]", "FACT complex subunit Spt16 [IPR040258]", "FAD synthetase with the MoaB/Mog domain [IPR012183]", "FAD-dependent glycerol-3-phosphate dehydrogenase [IPR000447]", "FAD-dependent oxidoreductase SdhA/FrdA/AprA [IPR030664]", "FAM98 [IPR018797]", "FUN14 [IPR007014]", "Family of unknown function DUF5525 [IPR037656]", "Fanconi anemia group I protein [IPR026171]", "Fascin [IPR010431]", "Fascin, metazoans [IPR024703]", "Fascin-1 [IPR030146]", "Fatty acid desaturase [IPR012171]", "Fatty acid oxidation complex, alpha subunit, mitochondrial [IPR012803]", "Fatty acid transport protein 4 [IPR030304]", "Fatty acyl-CoA reductase [IPR026055]", "Fcf2/DNTTIP2 [IPR039883]", "Ferrochelatase [IPR001015]", "Fibrillarin [IPR000692]", "Filamin family [IPR044801]", "Filamin-B [IPR029874]", "Fimbrin/Plastin [IPR039959]", "Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 [IPR033756]", "Flap endonuclease 1 [IPR023426]", "Flotillin family [IPR027705]", "Forkhead box protein C1 [IPR033067]", "Formate-tetrahydrofolate ligase, FTHFS [IPR000559]", "Formin, protein diaphanous homologue 1 [IPR027653]", "Formin, protein diaphanous homologue 3 [IPR027654]", "Four and a half LIM domains protein 1 [IPR042997]", "Fragile X mental retardation syndrome-related protein [IPR040148]", "Fructosamine/Ketosamine-3-kinase [IPR016477]", "Fructose-bisphosphate aldolase, class-I [IPR000741]", "Fumarate hydratase, class II [IPR005677]", "Fumarate lyase family [IPR000362]", "Fumarylacetoacetase [IPR005959]", "G-protein alpha subunit, group 12/13 [IPR000469]", "G-protein alpha subunit, group I [IPR001408]", "G-rich sequence factor 1 [IPR033106]", "GDP dissociation inhibitor [IPR018203]", "GDP-L-fucose synthase/GDP-L-colitose synthase [IPR028614]", "GINS complex subunit Sld5 [IPR008591]", "GINS complex, subunit Psf1 [IPR005339]", "GPCR-associated sorting protein [IPR043374]", "GPI transamidase component Gaa1 [IPR007246]", "GPI transamidase component PIG-T [IPR007245]", "GRASP55/65 [IPR007583]", "GRIP1-associated protein 1 [IPR026204]", "GTP-binding protein 1 [IPR039263]", "GTP-binding protein Era [IPR005662]", "GTP-binding protein Obg/CgtA [IPR014100]", "Galactokinase [IPR000705]", "Gamma-adducin [IPR027772]", "Gamma-glutamylcyclotransferase [IPR017939]", "Gamma-tubulin complex component protein [IPR007259]", "Ganglioside GM2 activator [IPR028996]", "Gem-associated protein 4 [IPR033265]", "General transcription factor 3C polypeptide 4 [IPR044230]", "Geranylgeranyl transferase type-2 subunit alpha [IPR032955]", "Glomulin/ALF4 [IPR019516]", "Glucosamine-6-phosphate isomerase [IPR004547]", "Glucosamine-fructose-6-phosphate aminotransferase, isomerising [IPR005855]", "Glucose-6-phosphate dehydrogenase [IPR001282]", "Glucosidase II beta subunit-like [IPR039794]", "Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase [IPR005715]", "Glutamate carboxypeptidase 2-like [IPR039373]", "Glutamate/acetylglutamate kinase [IPR001057]", "Glutamate/phenylalanine/leucine/valine dehydrogenase [IPR006095]", "Glutaminase [IPR015868]", "Glutamine-tRNA synthetase [IPR004514]", "Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic [IPR004526]", "Glutamyl-tRNA(Gln) amidotransferase A subunit [IPR004412]", "Glutamyl/glutaminyl-tRNA synthetase [IPR000924]", "Glutathione S-transferase Omega/Tau-like [IPR045073]", "Glutathione S-transferase kappa [IPR044088]", "Glutathione S-transferase, Mu class [IPR003081]", "Glutathione S-transferase, omega-class [IPR005442]", "Glutathione S-transferases, class Zeta [IPR005955]", "Glutathione Transferase family [IPR040079]", "Glutathione reductase, eukaryote/bacterial [IPR006322]", "Glutathione synthase [IPR005615]", "Glyceraldehyde-3-phosphate dehydrogenase, type I [IPR006424]", "Glyceraldehyde/Erythrose phosphate dehydrogenase family [IPR020831]", "Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase [IPR022284]", "Glycine cleavage system P protein [IPR020581]", "Glycine dehydrogenase (decarboxylating) [IPR003437]", "Glycogen debranching enzyme [IPR010401]", "Glycogen debranching enzyme, metazoa [IPR006421]", "Glycogen synthase [IPR008631]", "Glycogen synthase kinase-3 beta [IPR033573]", "Glycogen/starch/alpha-glucan phosphorylase [IPR011833]", "Glycoside hydrolase family 30 [IPR001139]", "Glycoside hydrolase family 31 [IPR000322]", "Glycoside hydrolase family 63 [IPR004888]", "Glycoside hydrolase, family 2 [IPR006101]", "Glycoside hydrolase, family 27 [IPR002241]", "Glycoside hydrolase, family 29 [IPR000933]", "Glycoside hydrolase, family 35 [IPR001944]", "Glycosyl transferase, family 25 [IPR002654]", "Glycosyl transferase, family 35 [IPR000811]", "Glycyl-tRNA synthetase [IPR002315]", "Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2 [IPR027031]", "Glyoxalase I [IPR004361]", "Glyoxalase domain-containing protein 4 [IPR043193]", "Golgi apparatus protein 1 [IPR039728]", "Golgi integral membrane protein 4 [IPR042336]", "Golgi to ER traffic protein 4 [IPR007317]", "Golgin subfamily A member 3 [IPR033288]", "Golgin subfamily B member 1 [IPR026202]", "Graves disease carrier protein [IPR002167]", "GroES chaperonin family [IPR020818]", "Growth arrest/ DNA-damage-inducible protein-interacting protein 1 [IPR018472]", "GrpE nucleotide exchange factor [IPR000740]", "Guanine nucleotide binding protein (G-protein), alpha subunit [IPR001019]", "Guanine nucleotide-exchange factor Sec12-like [IPR045260]", "Guided entry of tail-anchored proteins factor CAMLG [IPR016719]", "H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 [IPR007504]", "H/ACA ribonucleoprotein complex, subunit Nhp2, eukaryote [IPR002415]", "HAD hydrolase, subfamily IA [IPR006439]", "HAD-superfamily hydrolase, subfamily IA, REG-2-like [IPR011949]", "HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase [IPR008380]", "HAD-superfamily hydrolase, subfamily IIA [IPR006357]", "HAD-superfamily hydrolase, subfamily IIA, CECR5 [IPR006353]", "HAUS augmin-like complex subunit 5 [IPR029131]", "HAUS complex subunit 5, metazoa [IPR026215]", "HCCA isomerase/glutathione S-transferase kappa [IPR014440]", "HMG-CoA lyase [IPR043594]", "HS1-associating protein X-1 [IPR017248]", "Haem oxygenase [IPR002051]", "Haem oxygenase-like [IPR016053]", "Haloacid dehalogenase-like hydrolase [IPR041492]", "Ham1-like protein [IPR002637]", "Heat shock 70kDa protein 13 [IPR042048]", "Heat shock protein 70 family [IPR013126]", "Heat shock protein Hsp90 family [IPR001404]", "Heat shock protein Sti1-like [IPR045248]", "Helicase MOV-10 [IPR026122]", "Helicase XPB/Ssl2 [IPR001161]", "Helicase superfamily 1/2, DinG/Rad3-like [IPR045028]", "Heterochromatin protein 1-binding protein 3 [IPR033061]", "Heterogeneous nuclear ribonucleoprotein C [IPR017347]", "Heterogeneous nuclear ribonucleoprotein K [IPR033090]", "Heterogeneous nuclear ribonucleoprotein M [IPR024667]", "Heterogeneous nuclear ribonucleoprotein U [IPR026745]", "Heterogeneous nuclear ribonucleoprotein U-like protein 1 [IPR027025]", "Hexokinase [IPR001312]", "High mobility group protein HMG-I/HMG-Y, chordates [IPR031079]", "High mobility group protein HMGA [IPR000116]", "High mobility group protein HMGB1 [IPR031076]", "High mobility group protein HMGB3 [IPR031077]", "Histidine acid phosphatase, eukaryotic [IPR016274]", "Histidine phosphatase superfamily, clade-1 [IPR013078]", "Histidine phosphatase superfamily, clade-2 [IPR000560]", "Histidine triad (HIT) protein [IPR001310]", "Histone H2A [IPR002119]", "Histone H4 [IPR001951]", "Histone PARylation factor 1 [IPR019361]", "Histone acetyltransferase type B, catalytic subunit [IPR017380]", "Histone deacetylase [IPR003084]", "Histone deacetylase complex, SAP18 subunit [IPR017250]", "Histone deacetylase family [IPR000286]", "Histone demethylase JHDM2-like [IPR045109]", "Histone lysine-specific demethylase [IPR017366]", "Histone-lysine N-methyltransferase 2A [IPR037927]", "Histone-lysine N-methyltransferase Smyd3 [IPR025805]", "HnRNP R/Q splicing factor [IPR006535]", "HnRNP-L/PTB [IPR006536]", "Holocytochrome c/c1 synthase [IPR000511]", "Homeobox protein Hox-A10/abdominal-B-like [IPR046333]", "Host cell factor 1 [IPR037854]", "Host cell factor [IPR043536]", "Huntingtin [IPR000091]", "Huntingtin family [IPR028426]", "Hydantoinase/dihydropyrimidinase [IPR011778]", "Hydroxymethylglutaryl-CoA synthase, eukaryotic [IPR010122]", "Hypoxanthine phosphoribosyl transferase [IPR005904]", "Hypoxia-inducible factor 1-alpha inhibitor [IPR027445]", "I-BAR domain containing protein IRSp53 [IPR030128]", "I-BAR domain containing protein IRSp53/IRTKS/Pinkbar [IPR027681]", "ICln [IPR003521]", "Immunity-related GTPase family Q protein [IPR040070]", "Importin beta family [IPR040122]", "Importin subunit alpha [IPR024931]", "Inhibitor of nuclear factor kappa-B kinase-interacting protein [IPR024152]", "Initiation factor 2B alpha/beta/delta [IPR011559]", "Initiation factor 2B-related [IPR000649]", "Initiation factor 4G [IPR045208]", "Inner centromere protein [IPR039130]", "Inner nuclear membrane protein Man1 [IPR034997]", "Inorganic pyrophosphatase [IPR008162]", "Inosine triphosphate pyrophosphatase [IPR027502]", "Inosine-5'-monophosphate dehydrogenase [IPR005990]", "Insulin receptor substrate [IPR039011]", "Integral membrane protein EMC3/TMCO1-like [IPR002809]", "Integrator complex subunit 14 [IPR039841]", "Integrator complex subunit 3 [IPR045334]", "Integrin beta subunit [IPR015812]", "Integrin beta-1 subunit [IPR027071]", "Interferon-induced protein with tetratricopeptide repeat 5 [IPR024125]", "Interleukin enhancer-binding factor 3 [IPR033099]", "Intracellular chloride channel [IPR002946]", "Intraflagellar transport protein 27 homologue, eukaryotes [IPR034112]", "Inverted formin-2 [IPR027649]", "Iron regulatory protein 1 [IPR029784]", "Isocitrate dehydrogenase NAD-dependent [IPR004434]", "Isocitrate dehydrogenase NADP-dependent [IPR004790]", "Isoleucine-tRNA ligase [IPR002301]", "Isoleucine-tRNA ligase, type 1 [IPR023585]", "Isoleucine-tRNA ligase, type 2 [IPR023586]", "Isopentenyl-diphosphate delta-isomerase, type 1 [IPR011876]", "Isoprenylcysteine carboxyl methyltransferase [IPR007269]", "Isovaleryl-CoA dehydrogenase [IPR034183]", "J-protein Zuotin/DnaJC2 [IPR044634]", "JNK-interacting protein 3/4 [IPR039911]", "Junction plakoglobin [IPR030461]", "Junctional adhesion molecule A [IPR042456]", "KH domain-containing BBP-like [IPR045071]", "KIF-1 binding protein [IPR022083]", "KRR1 interacting protein 1 [IPR018034]", "Kelch-like ECH-associated protein 1 [IPR030563]", "Keratin, type I [IPR002957]", "Keratinocyte-associated transmembrane protein 2 [IPR037645]", "Kindlin/fermitin [IPR037843]", "Kinectin [IPR024854]", "Kinesin light chain [IPR002151]", "Kinesin-like protein KIF22 (Kid) [IPR026986]", "Kinesin-like protein [IPR027640]", "Ku70 [IPR006165]", "Ku80 [IPR024193]", "Kynurenine--oxoglutarate transaminase 3 [IPR034612]", "L-lactate dehydrogenase [IPR011304]", "L-lactate/malate dehydrogenase [IPR001557]", "LAMTOR1/MEH1 [IPR028209]", "LETM1/MDM38-like [IPR044202]", "LIM domain and actin-binding protein 1 [IPR028740]", "LIM domain and actin-binding protein LIMA-like [IPR045268]", "La domain containing protein [IPR045180]", "LanC-like protein, eukaryotic [IPR020464]", "Lanthionine synthetase C-like [IPR007822]", "Las1 [IPR007174]", "Lethal(2) giant larvae protein [IPR000664]", "Leucine-rich PPR motif-containing protein [IPR033490]", "Leucine-rich repeat protein SHOC2 [IPR027036]", "Leucine-tRNA ligase [IPR002302]", "Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic [IPR004493]", "Leukotriene A4 hydrolase/leucine aminopeptidase [IPR012777]", "Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase [IPR014190]", "Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3 [IPR027141]", "Linker histone H1/H5 [IPR005819]", "Lipase, eukaryotic [IPR025483]", "Lipid droplet-associated hydrolase [IPR019363]", "Lon protease [IPR027065]", "Lon protease homologue, chloroplastic/mitochondrial [IPR027503]", "Lon protease, bacterial/eukaryotic-type [IPR004815]", "Long-chain fatty acid CoA synthetase, eukaryotic [IPR045311]", "Low temperature viability protein Ltv1 [IPR007307]", "Luc7-related [IPR004882]", "Lupus La protein [IPR002344]", "Lysine-tRNA ligase, class II [IPR002313]", "Lysophosphatidylserine lipase ABHD12 [IPR026605]", "Lysosome membrane protein II [IPR005429]", "Lysosome-associated membrane glycoprotein [IPR002000]", "MCT-1/Tma20 [IPR016437]", "MDN2-binding protein [IPR039061]", "MICOS complex subunit MIC19/MIC25 [IPR007964]", "MICOS complex subunit MIC26/MIC27 [IPR019166]", "MICOS complex subunit MIC26/MIC27, animal [IPR033182]", "MICOS complex subunit Mic13 [IPR026769]", "MOB kinase activator family [IPR005301]", "MRG [IPR008676]", "MRPS27/PTCD2 [IPR034913]", "Macrophage migration inhibitory factor [IPR001398]", "Magnesium transporter protein 1 [IPR006844]", "Major centromere autoantigen B [IPR033062]", "Major facilitator superfamily [IPR011701]", "Mak16 protein [IPR006958]", "Malate dehydrogenase, NAD-dependent, cytosolic [IPR011274]", "Malate dehydrogenase, type 1 [IPR010097]", "Malate dehydrogenase, type 2 [IPR010945]", "Malectin [IPR039155]", "Malic oxidoreductase [IPR001891]", "Manganese/iron superoxide dismutase [IPR001189]", "Mannose-6-phosphate isomerase [IPR016305]", "Mannose-6-phosphate isomerase, type I [IPR001250]", "Mediator complex, subunit Med16 [IPR021665]", "Medium-chain dehydrogenase/reductase [IPR045010]", "Medium-chain specific acyl-CoA dehydrogenase [IPR034180]", "Melanoma-associated antigen D2 [IPR028810]", "Melanoma-associated antigen [IPR037445]", "Membrane bound O-acyl transferase, MBOAT [IPR004299]", "Membrane magnesium transporter [IPR018937]", "Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein [IPR001129]", "Mesoderm induction early response protein/metastasis-associated protein [IPR040138]", "Metal-dependent protein hydrolase [IPR003226]", "Metastasis-associated protein MTA2 [IPR037964]", "Methionine-tRNA ligase, type 1 [IPR023458]", "Methionyl-tRNA synthetase [IPR014758]", "Methyl-CpG binding protein MeCP2 [IPR017353]", "Methyl-CpG binding protein MeCP2/MBD4 [IPR045138]", "Methyl-CpG-binding domain protein 3 [IPR037965]", "Methylcrotonoyl-CoA carboxylase beta chain MCCB/AccD1-like [IPR045190]", "Methylmalonate-semialdehyde dehydrogenase [IPR010061]", "Methylthioadenosine phosphorylase (MTAP) [IPR010044]", "Methylthioribose-1-phosphate isomerase [IPR005251]", "Methylthiotransferase [IPR005839]", "Methyltransferase, trithorax [IPR016569]", "Mevalonate/galactokinase [IPR006206]", "MiaB-like tRNA modifying enzyme, archaeal-type [IPR006466]", "Microprocessor complex subunit DGCR8 [IPR040375]", "Microtubule associated protein 1 [IPR026074]", "Microtubule-associated protein 1B [IPR027321]", "Microtubule-associated protein 1S [IPR027322]", "Microtubule-associated protein 4 [IPR027323]", "Microtubule-associated protein Jupiter [IPR033335]", "Microtubule-associated protein RP/EB [IPR027328]", "Microtubule-associated protein, MAP65/Ase1/PRC1 [IPR007145]", "Midasin [IPR012099]", "Midline-1 [IPR027727]", "Mini-chromosome maintenance complex protein 4 [IPR008047]", "Mini-chromosome maintenance complex-binding protein [IPR019140]", "Mini-chromosome maintenance protein [IPR031327]", "Mitochondrial 18kDa protein [IPR019560]", "Mitochondrial 28S ribosomal protein S31 [IPR026299]", "Mitochondrial 28S ribosomal protein S34 [IPR032053]", "Mitochondrial ATP synthase subunit g, animal [IPR016702]", "Mitochondrial ATPase inhibitor [IPR007648]", "Mitochondrial F1-F0 ATP synthase subunit F, predicted [IPR019344]", "Mitochondrial Rho GTPase 1 [IPR029506]", "Mitochondrial Rho GTPase [IPR021181]", "Mitochondrial carrier UCP-like [IPR002030]", "Mitochondrial carrier protein [IPR002067]", "Mitochondrial glycoprotein [IPR003428]", "Mitochondrial import inner membrane translocase subunit Tim44 [IPR017303]", "Mitochondrial import inner membrane translocase subunit Tim50 [IPR027111]", "Mitochondrial import inner membrane translocase subunit Tim8/13 [IPR039238]", "Mitochondrial import receptor subunit TOM5, metazoa [IPR029179]", "Mitochondrial import receptor subunit Tom22 [IPR005683]", "Mitochondrial inner membrane protein Mitofilin [IPR019133]", "Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678]", "Mitochondrial inner membrane translocase complex, subunit Tim23 [IPR005681]", "Mitochondrial outer membrane translocase complex, subunit Tom5 [IPR019603]", "Mitochondrial outer membrane transport complex protein, metaxin [IPR017410]", "Mitochondrial phosphate carrier protein Pic2/Mir1-like [IPR044677]", "Mitochondrial processing peptidase subunit beta [IPR037718]", "Mitochondrial ribonuclease P catalytic subunit [IPR033495]", "Mitochondrial ribosomal protein L48 [IPR027487]", "Mitochondrial-processing peptidase subunit alpha [IPR037715]", "Mitofusin family [IPR027094]", "Mitofusin-1 [IPR027088]", "Mitofusin-2 [IPR027089]", "Mitogen-activated protein (MAP) kinase phosphatase [IPR008343]", "Mitotic spindle checkpoint protein Bub1/Mad3 [IPR015661]", "Monocarboxylate transporter 1 [IPR030757]", "Monocarboxylate transporter [IPR004743]", "Monothiol glutaredoxin-related [IPR004480]", "Mortality factor 4-like protein 1 [IPR038011]", "Mpv17/PMP22 [IPR007248]", "Mrp/NBP35 ATP-binding protein [IPR019591]", "Multidrug resistance protein 1 [IPR030258]", "Multiple myeloma tumor-associated protein 2-like [IPR039207]", "Myelin expression factor 2 [IPR034632]", "Myo-inositol-1-phosphate synthase [IPR002587]", "Myotubularin family [IPR030564]", "Myotubularin-related protein 6 [IPR030581]", "Myristoyl-CoA:protein N-myristoyltransferase [IPR000903]", "Myristoylated alanine-rich C-kinase substrate MARCKS [IPR002101]", "N-acetyl-D-glucosamine kinase NAGK-like [IPR039758]", "N-acetylglucosamine-6-sulfatase [IPR012251]", "N-acetylglucosamine-6-sulfatase, metazoan [IPR015981]", "N-acetyltransferase B complex, non-catalytic subunit [IPR019183]", "N-alpha-acetyltransferase 40 [IPR039949]", "N-terminal acetyltransferase A, auxiliary subunit [IPR021183]", "NAD kinase 2, mitochondrial [IPR012355]", "NAD kinase [IPR002504]", "NAD(P) transhydrogenase, alpha subunit [IPR026255]", "NAD(P)H-quinone oxidoreductase subunit D/H [IPR022885]", "NAD/FAD transporter SLC25A32-like [IPR044712]", "NADH dehydrogenase, subunit C [IPR010218]", "NADH ubiquinone oxidoreductase, F subunit [IPR011537]", "NADH-quinone oxidoreductase subunit E-like [IPR002023]", "NADH-ubiquinone oxidoreductase, 20 Kd subunit [IPR006138]", "NADH-ubiquinone reductase complex 1 MLRQ subunit [IPR010530]", "NADH:cytochrome b5 reductase-like [IPR001834]", "NADH:ubiquinone oxidoreductase, ESSS subunit [IPR019329]", "NADH:ubiquinone oxidoreductase, subunit G [IPR010228]", "NADH:ubiquinone oxidoreductase, subunit NDUFB4 [IPR009866]", "NADPH-cytochrome P450 reductase [IPR023208]", "NDRG [IPR004142]", "NEDD8 ultimate buster 1 [IPR039749]", "NEDD8-activating enzyme E1 catalytic subunit [IPR030468]", "NOL6/Upt22 [IPR005554]", "NPC1-like [IPR004765]", "NSF attachment protein [IPR000744]", "Na(+)/H(+) exchange regulatory cofactor NHERF-1 [IPR031199]", "Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 [IPR017300]", "Nck-associated protein 1 [IPR019137]", "Nectin-2 [IPR033318]", "Nesprin-2 [IPR030266]", "Nestin [IPR031211]", "Neurofilament light polypeptide [IPR027692]", "Neurofilament medium polypeptide [IPR027697]", "Neuroplastin [IPR027112]", "Neutral amino acid SLC6 transporter [IPR002438]", "Nicalin [IPR016574]", "Nicastrin [IPR008710]", "Nicotinamide phosphoribosyl transferase [IPR016471]", "Nitric oxide synthase-interacting protein [IPR016818]", "Nonaspanin (TM9SF) [IPR004240]", "Nonsense-mediated mRNA decay protein 3 [IPR039722]", "Not2/Not3/Not5 [IPR040168]", "Nuclear RNA export factor [IPR030217]", "Nuclear cap-binding protein subunit 1 [IPR027159]", "Nuclear factor hnRNPA1 [IPR021662]", "Nuclear fragile X mental retardation-interacting protein 2 [IPR032747]", "Nuclear mitotic apparatus protein 1 [IPR026650]", "Nuclear polyadenylated RNA-binding protein Nab2/ZC3H14 [IPR040366]", "Nuclear pore complex protein NUP98-NUP96 [IPR037637]", "Nuclear pore complex protein Nup133-like [IPR037624]", "Nuclear pore complex protein [IPR026054]", "Nuclear pore glycoprotein p62, metazoa [IPR033072]", "Nuclear pore membrane glycoprotein 210-like [IPR045197]", "Nuclear pore protein 84/107 [IPR007252]", "Nuclear protein localization protein 4 [IPR016563]", "Nuclear transport factor 2/Mtr2 [IPR045875]", "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 [IPR026633]", "Nucleobindin [IPR040250]", "Nucleobindin-1 [IPR040253]", "Nucleobindin-2 [IPR028813]", "Nucleolar GTP-binding protein 1 [IPR024926]", "Nucleolar GTP-binding protein 2 [IPR024929]", "Nucleolar and spindle-associated protein 1 [IPR026756]", "Nucleolar complex protein 2 [IPR005343]", "Nucleolar complex protein 4 [IPR027193]", "Nucleolar complex-associated protein 3 [IPR016903]", "Nucleolar protein 11 [IPR042859]", "Nucleolar protein 7 [IPR039626]", "Nucleolar protein Nop56/Nop58 [IPR045056]", "Nucleolar, Nop52 [IPR010301]", "Nucleoplasmin family [IPR004301]", "Nucleoporin NSP1/NUP62 [IPR026010]", "Nucleoporin NUP88/NUP82 [IPR037700]", "Nucleoporin Nup120/160 [IPR021717]", "Nucleoporin Nup186/Nup192/Nup205 [IPR021827]", "Nucleoporin Nup188 [IPR044840]", "Nucleoporin Nup37 [IPR037626]", "Nucleoporin Nup54/Nup57/Nup44 [IPR024864]", "Nucleoporin Nup85-like [IPR011502]", "Nucleoporin Nup88 [IPR019321]", "Nucleoporin Seh1 [IPR037597]", "Nucleoporin interacting component Nup93/Nic96 [IPR007231]", "Nucleoporin peptidase S59-like [IPR037665]", "Nucleoporin protein Ndc1-Nup [IPR019049]", "Nucleoporin, NUP53 [IPR017389]", "Nucleoporin, Nup155-like [IPR004870]", "Nucleoside 2-deoxyribosyltransferase [IPR007710]", "Nucleoside diphosphate kinase [IPR001564]", "Nucleoside-triphosphatase, THEP1 type [IPR004948]", "Nucleosome assembly protein (NAP) [IPR002164]", "Nucleosome-remodeling factor subunit BPTF [IPR038028]", "NudC domain-containing protein 1 [IPR037895]", "NudC family [IPR037898]", "OBG-type GTPase [IPR045086]", "OCIA domain-containing protein 1/2 [IPR040187]", "Occludin [IPR002958]", "Oligoribonuclease [IPR022894]", "Oligosaccharyl transferase complex, subunit OST3/OST6 [IPR021149]", "Oligosaccharyl transferase, STT3 subunit [IPR003674]", "Optic atrophy 3-like [IPR010754]", "Ornithine aminotransferase [IPR010164]", "Orotate phosphoribosyltransferase [IPR023031]", "Orotidine 5'-phosphate decarboxylase [IPR014732]", "Oxidized purine nucleoside triphosphate [IPR003563]", "Oxysterol-binding protein [IPR000648]", "P-type ATPase [IPR001757]", "P-type ATPase subfamily IIC, subunit alpha [IPR005775]", "P-type ATPase, subfamily IIA, SERCA-type [IPR005782]", "P-type ATPase, subfamily V [IPR006544]", "P-type ATPase, subfamily IIB [IPR006408]", "PA2G4 family [IPR004545]", "PAT complex subunit CCDC47 [IPR012879]", "PDCD5-like [IPR002836]", "PDK/BCKDK protein kinase [IPR039028]", "PDZ and LIM domain protein 1 [IPR028537]", "PEST proteolytic signal-containing nuclear protein [IPR029169]", "PH-interacting protein [IPR028738]", "PHF5-like [IPR005345]", "PITH domain-containing protein 1-like [IPR045099]", "Pachytene checkpoint protein 2-like [IPR044539]", "Palmitoyl protein thioesterase [IPR002472]", "Palmitoyl-protein thioesterase 1 [IPR030294]", "Pantothenate kinase, acetyl-CoA regulated, two-domain type [IPR015844]", "Paraneoplastic encephalomyelitis antigen [IPR002343]", "Paraoxonase2 [IPR008364]", "Pentatricopeptide repeat domain-containing protein 3 [IPR037387]", "Peptidase A22B, signal peptide peptidase [IPR007369]", "Peptidase C13, legumain [IPR001096]", "Peptidase C1B, bleomycin hydrolase [IPR004134]", "Peptidase C2, calpain family [IPR022684]", "Peptidase C26 [IPR011697]", "Peptidase C26, gamma-glutamyl hydrolase [IPR015527]", "Peptidase C54 [IPR005078]", "Peptidase C65, otubain [IPR019400]", "Peptidase C69, dipeptidase A [IPR005322]", "Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930]", "Peptidase M1, aminopeptidase B [IPR015571]", "Peptidase M13 [IPR000718]", "Peptidase M14B, caboxypeptidase D [IPR015567]", "Peptidase M17, leucine aminopeptidase [IPR023042]", "Peptidase M17, leucine aminopeptidase/peptidase B [IPR011356]", "Peptidase M20 [IPR002933]", "Peptidase M24, methionine aminopeptidase [IPR001714]", "Peptidase M24A, methionine aminopeptidase, subfamily 2 [IPR002468]", "Peptidase M3A/M3B [IPR045090]", "Peptidase S10, serine carboxypeptidase [IPR001563]", "Peptidase S1C [IPR001940]", "Peptidase S26B [IPR001733]", "Peptidase S28 [IPR008758]", "Peptidase S8, subtilisin-related [IPR015500]", "Peptidase S9A, prolyl oligopeptidase [IPR002470]", "Peptidase T1A, proteasome beta-subunit [IPR000243]", "Peptidase T2, asparaginase 2 [IPR000246]", "Peptidase family M49 [IPR039461]", "Peptidase, FtsH [IPR005936]", "Peptide chain release factor eRF1/aRF1 [IPR004403]", "Peptidyl-prolyl cis-trans isomerase FKBP2/11 [IPR044609]", "Peptidyl-prolyl cis-trans isomerase FKBP3 [IPR043368]", "Peptidyl-prolyl cis-trans isomerase FKBP4 [IPR031212]", "Peptidyl-prolyl cis-trans isomerase FKBP5 [IPR031210]", "Peptidyl-prolyl cis-trans isomerase PIN4 [IPR043323]", "Peptidyl-tRNA hydrolase, PTH2 [IPR002833]", "Pericentriolar material 1 protein [IPR024138]", "Perilipin [IPR004279]", "Periodic tryptophan protein 1 [IPR044285]", "Periodic tryptophan protein 2 [IPR027145]", "Peroxiredoxin, AhpC-type [IPR024706]", "Peroxiredoxin-5-like [IPR037944]", "Peroxisomal acyl-coenzyme A oxidase [IPR034171]", "Peroxisomal membrane protein 14 [IPR025655]", "Peroxysomal long chain fatty acyl transporter [IPR005283]", "Pescadillo [IPR010613]", "Phenylalanine-tRNA ligase, class IIc, beta subunit [IPR045060]", "Phenylalanyl-tRNA synthetase, class IIc, alpha subunit [IPR004529]", "Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archael/eukaryotic type [IPR004531]", "Phosducin-like [IPR045037]", "Phosphatidate cytidylyltransferase, mitochondrial [IPR015222]", "Phosphatidyl serine synthase [IPR004277]", "Phosphatidylethanolamine-binding protein [IPR008914]", "Phosphatidylethanolamine-binding protein, eukaryotic [IPR035810]", "Phosphatidylinositol kinase [IPR015433]", "Phosphatidylinositol transfer protein [IPR001666]", "Phosphatidylinositol-binding clathrin assembly protein [IPR030412]", "Phosphatidylinositol-glycan biosynthesis class S protein [IPR019540]", "Phosphatidylserine decarboxylase [IPR033177]", "Phosphatidylserine decarboxylase, eukaryotic type 1 [IPR033661]", "Phosphatidylserine decarboxylase-related [IPR003817]", "Phosphoacetylglucosamine mutase [IPR016657]", "Phosphodiesterase MJ0936/Vps29 [IPR000979]", "Phosphoglucomutase [IPR045244]", "Phosphoglucose isomerase (PGI) [IPR001672]", "Phosphoglycerate kinase [IPR001576]", "Phosphoglycerate mutase 1 [IPR005952]", "Phospholipase B-like [IPR007000]", "Phosphoribosylformylglycinamidine cyclo-ligase [IPR004733]", "Phosphoribosylformylglycinamidine synthase PurL [IPR010073]", "Phosphoribosylglycinamide formyltransferase [IPR004607]", "Phosphoribosylglycinamide synthetase [IPR000115]", "Phosphorylated adapter RNA export protein [IPR039047]", "Phosphoserine aminotransferase [IPR022278]", "Phosphotyrosyl phosphatase activator, PTPA [IPR004327]", "Pinin [IPR039853]", "Pirin [IPR012093]", "Plakin [IPR043197]", "Plakophilin/Delta catenin [IPR028435]", "Plasma membrane calcium-transporting ATPase 1 [IPR030320]", "Plasminogen activator inhibitor 1 RNA-binding protein [IPR027205]", "Plastin-1 [IPR030235]", "Plastin-2/3 [IPR039956]", "Plectin [IPR030269]", "Polo kinase kinase [IPR022165]", "Poly(A) polymerase [IPR014492]", "Poly(ADP-ribose) glycohydrolase [IPR007724]", "Poly-U binding splicing factor, PUF60-like [IPR006532]", "Polyadenylate binding protein, human types 1, 2, 3, 4 [IPR006515]", "Polyadenylate-binding protein 2 [IPR034911]", "Polyprenyl synthetase [IPR000092]", "Polyribonucleotide 5-hydroxyl-kinase Clp1/Grc3 [IPR045116]", "Polyribonucleotide nucleotidyltransferase [IPR012162]", "Porin, eukaryotic type [IPR001925]", "Pre-mRNA 3' end processing protein Pfs2-like [IPR045245]", "Pre-mRNA-processing factor 19 [IPR038959]", "Pre-mRNA-processing factor 6/Prp1/STA1 [IPR027108]", "Pre-mRNA-processing factor Prp40 [IPR039726]", "Pre-mRNA-processing-splicing factor 8 [IPR027652]", "Pre-mRNA-splicing factor Cwf15/Cwc15 [IPR006973]", "Pre-mRNA-splicing factor 38 [IPR005037]", "Pre-mRNA-splicing factor Cwc2/Slt11 [IPR039171]", "Pre-mRNA-splicing factor SPF27 [IPR008409]", "Pre-mRNA-splicing factor Syf1-like [IPR045075]", "Pre-rRNA-processing protein Esf1 [IPR039754]", "Pre-rRNA-processing protein PNO1-like [IPR039912]", "Prefoldin alpha subunit, archaea-type [IPR011599]", "Prefoldin alpha-like [IPR004127]", "Prefoldin beta-like [IPR002777]", "Prefoldin subunit 2 [IPR027235]", "Prefoldin subunit 3 [IPR016655]", "Prenylated rab acceptor PRA1 [IPR004895]", "Prenylcysteine oxidase [IPR017046]", "Prenyltransferase subunit beta [IPR045089]", "Presenilin/signal peptide peptidase [IPR006639]", "Primosome PriB/single-strand DNA-binding [IPR000424]", "Probable ubiquitin carboxyl-terminal hydrolase FAF-X [IPR031226]", "Profilin [IPR005455]", "Profilin-1 [IPR029892]", "Profilin-2 [IPR029891]", "Profilin1/2/3, vertebrate [IPR005454]", "Programmed cell death protein 4 [IPR039778]", "Prohibitin [IPR000163]", "Proliferating cell nuclear antigen, PCNA [IPR000730]", "Proline-rich AKT1 substrate 1 protein [IPR026682]", "Proline-rich protein PRCC [IPR018800]", "Proline-tRNA ligase, class IIa, archaeal-type [IPR004499]", "Prolyl 3-hydroxylase 1 [IPR039837]", "Prolyl 3-hydroxylase [IPR039575]", "Prolyl 4-hydroxylase [IPR045054]", "Prostaglandin E synthase 2 [IPR034334]", "Prostaglandin reductase 2 [IPR037399]", "Proteasomal ubiquitin receptor Rpn13/ADRM1 [IPR006773]", "Proteasome B-type subunit [IPR023333]", "Proteasome activator PA28 [IPR009077]", "Proteasome activator complex subunit 4 [IPR035309]", "Proteasome alpha-type subunit [IPR023332]", "Proteasome assembly chaperone 1 [IPR016565]", "Proteasome assembly chaperone 2 [IPR019151]", "Proteasome assembly chaperone 2, eukaryotic [IPR016562]", "Proteasome assembly chaperone 3 [IPR018788]", "Proteasome beta 3 subunit [IPR033811]", "Proteasome component Ecm29 [IPR024372]", "Proteasome subunit alpha 1 [IPR035144]", "Proteasome subunit alpha 3 [IPR037555]", "Proteasome subunit alpha 7 [IPR035190]", "Proteasome subunit alpha2 [IPR034644]", "Proteasome subunit alpha4 [IPR034647]", "Proteasome subunit alpha5 [IPR033812]", "Proteasome subunit alpha6 [IPR034642]", "Proteasome subunit beta 1 [IPR035202]", "Proteasome subunit beta 2 [IPR035206]", "Proteasome subunit beta 4 [IPR016295]", "Proteasome subunit beta 5 [IPR037558]", "Proteasome subunit beta 6 [IPR035140]", "Proteasome subunit beta 7 [IPR035216]", "Proteasome, subunit alpha/beta [IPR001353]", "Protein AATF/Bfr2 [IPR039223]", "Protein BRAWNIN [IPR027858]", "Protein CIP2A [IPR042510]", "Protein CUSTOS [IPR026694]", "Protein Cms1 [IPR032704]", "Protein DEK [IPR044198]", "Protein ERGIC-53 [IPR033085]", "Protein FAM8A1 [IPR039871]", "Protein FRG1 [IPR010414]", "Protein ICln/Lot5/Saf5 [IPR039924]", "Protein LYRIC [IPR031402]", "Protein Lsm12-like [IPR039683]", "Protein NDRG3 [IPR030692]", "Protein PBDC1, metazoa/fungi [IPR008476]", "Protein PRRC2 [IPR033184]", "Protein Peter Pan-like [IPR045112]", "Protein RCC2 [IPR028641]", "Protein Red-like [IPR039896]", "Protein S100-A10 [IPR028476]", "Protein S100-A11 [IPR028482]", "Protein SON [IPR032922]", "Protein Sgt1-like [IPR044563]", "Protein TFG [IPR033512]", "Protein XRP2 [IPR039093]", "Protein arginine N-methyltransferase PRMT5 [IPR007857]", "Protein arginine N-methyltransferase [IPR025799]", "Protein arginine methyltransferase NDUFAF7 [IPR003788]", "Protein canopy homolog [IPR042415]", "Protein disulfide-isomerase A6-like [IPR044569]", "Protein disulphide isomerase [IPR005792]", "Protein disulphide-isomerase A4 [IPR017068]", "Protein farnesyltransferase subunit beta [IPR026872]", "Protein flightless-1 [IPR029919]", "Protein import receptor MAS20 [IPR002056]", "Protein import receptor MAS20, metazoan [IPR022422]", "Protein kinase C and casein kinase substrate in neurons protein 2 [IPR028521]", "Protein kinase Mps1 family [IPR027084]", "Protein of unknown function DUF1075 [IPR009432]", "Protein of unknown function DUF2046 [IPR019152]", "Protein of unknown function DUF719 [IPR007998]", "Protein patched/dispatched [IPR003392]", "Protein phosphatase 2A regulatory subunit PR55 [IPR000009]", "Protein phosphatase 2A, regulatory B subunit, B56 [IPR002554]", "Protein phosphatase 2C family [IPR015655]", "Protein phosphatase methylesterase, eukaryotic [IPR016812]", "Protein regulator of cytokinesis 1 [IPR032921]", "Protein transport Sec61-beta/Sbh [IPR030671]", "Protein transport protein SEC31-like [IPR040251]", "Protein transport protein Sec23 [IPR037364]", "Protein transport protein SecG/Sec61-beta/Sbh [IPR016482]", "Protein virilizer [IPR026736]", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase [IPR000682]", "Protein-S-isoprenylcysteine O-methyltransferase [IPR025770]", "Protein-glutamate O-methyltransferase [IPR039763]", "Protein-tyrosine phosphatase, low molecular weight [IPR017867]", "Protein-tyrosine phosphatase, low molecular weight, mammalian [IPR002115]", "Protein-tyrosine phosphatase, non-receptor type-1/2 [IPR012265]", "Protein-tyrosine phosphatase-like, PTPLA [IPR007482]", "Protein/nucleic acid deglycase DJ-1 [IPR006287]", "Proteinase inhibitor I25A, stefin [IPR001713]", "Pseudouridine synthase I, TruA [IPR001406]", "Pseudouridine synthase PUS1/ PUS2-like [IPR041708]", "Pseudouridine synthase, TruD [IPR001656]", "Pumilio homologue 3 [IPR040059]", "Purine 5'-nucleotidase [IPR016695]", "Purine nucleoside phosphorylase I, inosine/guanosine-specific [IPR011270]", "Purine nucleoside phosphorylase [IPR011268]", "Purine-rich element binding protein family [IPR006628]", "Purine-rich element-binding protein alpha [IPR030500]", "Putative peptidyl-tRNA hydrolase PTRHD1 [IPR042237]", "Pyridine nucleotide-disulphide oxidoreductase, class I [IPR001100]", "Pyridoxal phosphate-dependent decarboxylase [IPR002129]", "Pyrimidine 5'-nucleotidase, eukaryotic [IPR006434]", "Pyrroline-5-carboxylate reductase [IPR000304]", "Pyruvate carboxylase [IPR005930]", "Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y [IPR017597]", "Pyruvate dehydrogenase E1 component subunit beta [IPR027110]", "Pyruvate kinase [IPR001697]", "RAD3/XPD family [IPR001945]", "RAD51-associated protein 1 [IPR026632]", "RINT-1/Tip20 [IPR007528]", "RLI1 [IPR013283]", "RNA (C5-cytosine) methyltransferase [IPR023267]", "RNA (C5-cytosine) methyltransferase, NOP2 [IPR023273]", "RNA 3'-terminal phosphate cyclase [IPR000228]", "RNA 3'-terminal phosphate cyclase type 2 [IPR016443]", "RNA binding protein HABP4/SERBP1 [IPR039764]", "RNA cytidine acetyltransferase NAT10 [IPR033688]", "RNA demethylase ALKBH5 [IPR032860]", "RNA exonuclease 4 [IPR034920]", "RNA polymerase I associated factor, A49-like [IPR009668]", "RNA polymerase II associated factor Paf1 [IPR007133]", "RNA polymerase II subunit A [IPR006811]", "RNA polymerase II transcription factor SIII, subunit A [IPR010684]", "RNA polymerase II transcriptional coactivator Sub1/Tcp4-like [IPR045125]", "RNA polymerase subunit Rpb7-like [IPR045113]", "RNA transcription, translation and transport factor protein [IPR019265]", "RNA-binding motif protein 8 [IPR008111]", "RNA-binding protein 10 [IPR033095]", "RNA-binding protein 26 [IPR034861]", "RNA-binding protein 26/27 [IPR045137]", "RNA-binding protein 45 [IPR033101]", "RNA-binding protein 5 [IPR033094]", "RNA-binding protein EWS [IPR033109]", "RNA-binding protein FUS [IPR034459]", "RNA-binding protein NOB1 [IPR039907]", "RNA-induced silencing complex, nuclease component Tudor-SN [IPR016685]", "RNA-splicing ligase RtcB homologue, eukaryotic [IPR027513]", "RNA-splicing ligase, RtcB [IPR001233]", "RNase P subunit p30 [IPR002738]", "RPA-related protein RADX [IPR040893]", "RZZ complex, subunit Zw10 [IPR009361]", "Rab GDI protein [IPR000806]", "Rab GTPase-activating protein 1 [IPR033185]", "Rab-like protein 6 [IPR040385]", "Rab24 [IPR041828]", "Rab35 [IPR041815]", "Rab3GAP catalytic subunit [IPR045700]", "Rab3GAP regulatory subunit [IPR026059]", "Rad21/Rec8-like protein [IPR039781]", "Ragulator complex protein LAMTOR2-like [IPR037587]", "RalBP1-associated Eps domain-containing protein 1 [IPR026814]", "Ran GTPase [IPR002041]", "Ran binding protein RanBP1-like [IPR045255]", "Ras GTPase GNL1-like [IPR043358]", "Ras GTPase-activating protein-binding protein 1 [IPR034375]", "Ras GTPase-activating protein-binding protein 2 [IPR034377]", "Ras GTPase-activating protein-binding protein [IPR039539]", "Ras-related protein Rab14 [IPR030702]", "Ras-related protein Ral [IPR028412]", "Reduced folate carrier [IPR002666]", "Reduced folate transporter SLC19A1 [IPR028339]", "Remodeling and spacing factor 1-like [IPR028938]", "Remodelling complex subunit Rsc/polybromo [IPR037382]", "Replication factor A protein 1 [IPR004591]", "Replication factor A protein 3 [IPR013970]", "Replication factor C subunit 1 [IPR012178]", "Reticulon-4-interacting protein 1 [IPR037397]", "Retrieval of early ER protein Rer1 [IPR004932]", "Rho protein GDP-dissociation inhibitor [IPR000406]", "Rho-associated protein kinase 1/2 [IPR020684]", "Rho-related GTP-binding protein RhoG [IPR042734]", "Ribonuclease CAF1 [IPR006941]", "Ribonuclease H2, subunit A [IPR004649]", "Ribonuclease HII/HIII [IPR001352]", "Ribonuclease III [IPR011907]", "Ribonuclease Nob1, eukaryote [IPR017117]", "Ribonuclease T2, eukaryotic [IPR033697]", "Ribonuclease T2-like [IPR001568]", "Ribonucleases P/MRP protein subunit Pop1 [IPR039182]", "Ribonucleoprotein PTB-binding 1 [IPR034635]", "Ribonucleoside-diphosphate reductase large subunit [IPR039718]", "Ribonucleotide reductase small subunit [IPR033909]", "Ribonucleotide reductase small subunit family [IPR000358]", "Ribophorin I [IPR007676]", "Ribose-phosphate pyrophosphokinase [IPR005946]", "Ribosomal RNA adenine dimethylase [IPR011530]", "Ribosomal RNA adenine methyltransferase KsgA/Erm [IPR001737]", "Ribosomal RNA assembly KRR1 [IPR024166]", "Ribosomal RNA large subunit methyltransferase E [IPR015507]", "Ribosomal RNA processing protein 8 [IPR007823]", "Ribosomal RNA-processing protein 15 [IPR012459]", "Ribosomal RNA-processing protein 7 [IPR040446]", "Ribosomal RNA-processing protein Rrp9-like [IPR039241]", "Ribosomal biogenesis NSA2 family [IPR039411]", "Ribosomal biogenesis regulatory protein [IPR007023]", "Ribosomal biogenesis, methyltransferase, EMG1/NEP1 [IPR005304]", "Ribosomal protein L1 [IPR002143]", "Ribosomal protein L1, mitochondrial [IPR005879]", "Ribosomal protein L1/ribosomal biogenesis protein [IPR028364]", "Ribosomal protein L10P [IPR001790]", "Ribosomal protein L10e [IPR001197]", "Ribosomal protein L11, bacterial-type [IPR006519]", "Ribosomal protein L11/L12 [IPR000911]", "Ribosomal protein L12/P1/P2 family [IPR027534]", "Ribosomal protein L13 [IPR005822]", "Ribosomal protein L13, eukaryotic/archaeal [IPR005755]", "Ribosomal protein L13e [IPR001380]", "Ribosomal protein L14 [IPR039660]", "Ribosomal protein L14P [IPR000218]", "Ribosomal protein L15 [IPR030878]", "Ribosomal protein L15, bacterial-type [IPR005749]", "Ribosomal protein L15e [IPR000439]", "Ribosomal protein L18e [IPR000039]", "Ribosomal protein L19 [IPR001857]", "Ribosomal protein L2 [IPR002171]", "Ribosomal protein L2, archaeal-type [IPR023672]", "Ribosomal protein L21 [IPR001787]", "Ribosomal protein L21-like [IPR028909]", "Ribosomal protein L21e [IPR001147]", "Ribosomal protein L22/L17 [IPR001063]", "Ribosomal protein L22/L17, eukaryotic/archaeal [IPR005721]", "Ribosomal protein L22e [IPR002671]", "Ribosomal protein L23 [IPR019985]", "Ribosomal protein L24 [IPR003256]", "Ribosomal protein L24e-related [IPR000988]", "Ribosomal protein L25/L23 [IPR013025]", "Ribosomal protein L27e [IPR001141]", "Ribosomal protein L28/L24 [IPR026569]", "Ribosomal protein L28e [IPR002672]", "Ribosomal protein L29/L35 [IPR001854]", "Ribosomal protein L29e [IPR002673]", "Ribosomal protein L3 [IPR000597]", "Ribosomal protein L3, archaeal/eukaryotic type [IPR045077]", "Ribosomal protein L3, bacterial/organelle-type [IPR019927]", "Ribosomal protein L30/YlxQ [IPR039109]", "Ribosomal protein L30e [IPR000231]", "Ribosomal protein L31e [IPR000054]", "Ribosomal protein L32e [IPR001515]", "Ribosomal protein L34Ae [IPR008195]", "Ribosomal protein L35A [IPR001780]", "Ribosomal protein L36e [IPR000509]", "Ribosomal protein L37/S30 [IPR010793]", "Ribosomal protein L37ae [IPR002674]", "Ribosomal protein L37e [IPR001569]", "Ribosomal protein L38e [IPR002675]", "Ribosomal protein L4, eukaryotic and archaeal type [IPR045240]", "Ribosomal protein L4/L1e [IPR002136]", "Ribosomal protein L44e [IPR000552]", "Ribosomal protein L47, mitochondrial [IPR010729]", "Ribosomal protein L5 [IPR002132]", "Ribosomal protein L5 eukaryotic/L18 archaeal [IPR005485]", "Ribosomal protein L53, mitochondrial [IPR019716]", "Ribosomal protein L6 [IPR000702]", "Ribosomal protein L7, eukaryotic [IPR005998]", "Ribosomal protein L7/L12 [IPR000206]", "Ribosomal protein L7/L30 [IPR039699]", "Ribosomal protein L7A/L8 [IPR001921]", "Ribosomal protein L7Ae/L8/Nhp2 family [IPR018492]", "Ribosomal protein L9 [IPR000244]", "Ribosomal protein P2 [IPR044076]", "Ribosomal protein S10 [IPR001848]", "Ribosomal protein S10, eukaryotic/archaeal [IPR005729]", "Ribosomal protein S11 [IPR001971]", "Ribosomal protein S12/S23 [IPR006032]", "Ribosomal protein S12e [IPR000530]", "Ribosomal protein S13 [IPR001892]", "Ribosomal protein S15 [IPR000589]", "Ribosomal protein S15P [IPR023029]", "Ribosomal protein S17, archaeal/eukaryotic [IPR028333]", "Ribosomal protein S17/S11 [IPR000266]", "Ribosomal protein S17e [IPR001210]", "Ribosomal protein S19/S15 [IPR002222]", "Ribosomal protein S19A/S15e [IPR005713]", "Ribosomal protein S19e [IPR001266]", "Ribosomal protein S2 [IPR001865]", "Ribosomal protein S2, bacteria/mitochondria/plastid [IPR005706]", "Ribosomal protein S2, eukaryotic [IPR027498]", "Ribosomal protein S2, eukaryotic/archaeal [IPR005707]", "Ribosomal protein S21e [IPR001931]", "Ribosomal protein S22, mitochondrial [IPR019374]", "Ribosomal protein S23, eukaryotic/archaeal [IPR005680]", "Ribosomal protein S23, mitochondrial [IPR019520]", "Ribosomal protein S23/S29, mitochondrial [IPR019368]", "Ribosomal protein S24/S35, mitochondrial [IPR039848]", "Ribosomal protein S24e [IPR001976]", "Ribosomal protein S25 [IPR004977]", "Ribosomal protein S28e [IPR000289]", "Ribosomal protein S29, mitochondrial [IPR008092]", "Ribosomal protein S3, eukaryotic/archaeal [IPR005703]", "Ribosomal protein S30 [IPR006846]", "Ribosomal protein S30, mitochondrial [IPR039982]", "Ribosomal protein S3Ae [IPR001593]", "Ribosomal protein S4/S9 [IPR022801]", "Ribosomal protein S4/S9, eukaryotic/archaeal [IPR005710]", "Ribosomal protein S4e [IPR000876]", "Ribosomal protein S5 [IPR000851]", "Ribosomal protein S5, eukaryotic/archaeal [IPR005711]", "Ribosomal protein S5/S7 [IPR000235]", "Ribosomal protein S5/S7, eukaryotic/archaeal [IPR005716]", "Ribosomal protein S6 kinase II [IPR016239]", "Ribosomal protein S6, eukaryotic [IPR014401]", "Ribosomal protein S6e [IPR001377]", "Ribosomal protein S7e [IPR000554]", "Ribosomal protein S8 [IPR000630]", "Ribosomal protein S8e [IPR001047]", "Ribosomal protein S8e/ribosomal biogenesis NSA2 [IPR022309]", "Ribosomal protein S9 [IPR000754]", "Ribosome assembly factor Mrt4 [IPR033867]", "Ribosome biogenesis factor, NIP7 [IPR016686]", "Ribosome biogenesis protein BRX1 [IPR026532]", "Ribosome biogenesis protein Bms1/Tsr1 [IPR039761]", "Ribosome biogenesis protein Nop16 [IPR019002]", "Ribosome biogenesis protein Nop53/GLTSCR2 [IPR011687]", "Ribosome biogenesis protein Rpf2 [IPR039770]", "Ribosome maturation protein Sdo1/SBDS [IPR002140]", "Ribosome maturation protein Sdo1/SBDS-like [IPR039100]", "Ribosome recycling factor [IPR002661]", "Ribosome-binding ATPase YchF/Obg-like ATPase 1 [IPR004396]", "Ribosome-binding protein 1 [IPR040248]", "RuvB-like [IPR027238]", "RuvB-like helicase 1 [IPR037938]", "RuvB-like helicase 2 [IPR037942]", "S-adenosylmethionine synthetase [IPR002133]", "S-formylglutathione hydrolase [IPR014186]", "S-phase kinase-associated protein 1 [IPR016897]", "S-phase kinase-associated protein 1-like [IPR001232]", "SAP30-binding protein [IPR012479]", "SCAMP [IPR007273]", "SERRATE/Ars2 [IPR039727]", "SH3-binding, glutamic acid-rich protein [IPR006993]", "SIT4 phosphatase-associated protein family [IPR007587]", "SKI-interacting protein, SKIP [IPR017862]", "SLC12A transporter family [IPR004842]", "SNF5/SMARCB1/INI1 [IPR006939]", "SNU66/SART1 family [IPR005011]", "SOS response associated peptidase (SRAP) [IPR003738]", "SOUL haem-binding protein [IPR006917]", "SUMO-activating enzyme subunit Uba2 [IPR030661]", "SWI/SNF complex subunit BAF57 [IPR030089]", "SWI/SNF complex subunit BRG1 [IPR030100]", "SWI/SNF complex subunit SMARCC1 [IPR030087]", "SWI/SNF complex subunit SMARCC2 [IPR038044]", "SWI/SNF-like complex subunit BAF250a [IPR030094]", "SWI/SNF-like complex subunit BAF250/Osa [IPR021906]", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [IPR038041]", "Scaffold attachment factor B1 [IPR034781]", "Scaffold attachment factor B2 [IPR034782]", "Scavenger mRNA decapping enzyme DcpS/DCS2 [IPR008594]", "Scc2/Nipped-B family [IPR033031]", "Schlafen family [IPR029684]", "Sds3-like [IPR013907]", "Sec1-like protein [IPR001619]", "Sec13/Seh1 family [IPR037363]", "SecY/SEC61-alpha family [IPR002208]", "Selenophosphate synthetase [IPR004536]", "Sentrin-specific protease 3 [IPR037945]", "Sepiapterin reductase [IPR006393]", "Septin 2 [IPR008113]", "Septin 7 [IPR008115]", "Septin 9 [IPR030645]", "Septin [IPR016491]", "Serine hydroxymethyltransferase [IPR001085]", "Serine-tRNA ligase, type1 [IPR002317]", "Serine/arginine-rich splicing factor 10 [IPR034476]", "Serine/arginine-rich splicing factor 11 [IPR034447]", "Serine/arginine-rich splicing factor 2-like [IPR034893]", "Serine/threonine protein phosphatase 5 [IPR011236]", "Serine/threonine-protein kinase PAK2 [IPR035065]", "Serine/threonine-protein kinase TOR [IPR026683]", "Serine/threonine-protein phosphatase 2A subunit A, metazoa [IPR031090]", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit [IPR037979]", "Serpin H1 [IPR033547]", "Serpin family [IPR000215]", "Short transmembrane mitochondrial protein 1 [IPR027854]", "Short-chain dehydrogenase/reductase SDR [IPR002347]", "Sialidase family [IPR026856]", "Sigma intracellular receptor 2 [IPR016964]", "Signal peptidase complex catalytic subunit SEC11A [IPR037712]", "Signal peptidase complex subunit 3 [IPR007653]", "Signal peptidase complex subunit Spc2/SPCS2 [IPR009582]", "Signal recognition particle SRP9 [IPR039914]", "Signal recognition particle receptor, beta subunit [IPR019009]", "Signal recognition particle subunit SRP68 [IPR026258]", "Signal recognition particle, SRP14 subunit [IPR003210]", "Signal recognition particle, SRP19 subunit [IPR002778]", "Signal recognition particle, SRP54 subunit [IPR022941]", "Signal recognition particle, SRP54 subunit, eukaryotic [IPR006325]", "Signal recognition particle, SRP72 subunit [IPR026270]", "Signal recognition particle, SRP9 subunit [IPR008832]", "Sin3 associated polypeptide p18 [IPR010516]", "Single-stranded DNA-binding protein [IPR011344]", "Sirtuin family [IPR003000]", "Sirtuin, class I [IPR017328]", "Sister chromatid cohesion protein Pds5 [IPR039776]", "Ski3/TTC37 [IPR039226]", "Sm-like protein Lsm6/SmF [IPR016487]", "Smac/DIABLO protein [IPR015142]", "Small (40S) ribosomal subunit Asc1/RACK1 [IPR045223]", "Small GTPase Rho [IPR003578]", "Small GTPase [IPR001806]", "Small GTPase superfamily, ARF type [IPR024156]", "Small GTPase superfamily, ARF/SAR type [IPR006689]", "Small GTPase superfamily, SAR1-type [IPR006687]", "Small GTPase, Ras-type [IPR020849]", "Small nuclear ribonucleoprotein E [IPR027078]", "Small nuclear ribonucleoprotein Sm D2 [IPR027248]", "Small nuclear ribonucleoprotein Sm D3 [IPR034099]", "Small-subunit processome, Utp11 [IPR007144]", "Small-subunit processome, Utp14 [IPR006709]", "Smooth muscle protein/calponin [IPR003096]", "Snf7 family [IPR005024]", "Sodium/potassium-transporting ATPase subunit beta [IPR000402]", "Sodium/potassium-transporting ATPase subunit beta, chordates [IPR015565]", "Sodium:dicarboxylate symporter [IPR001991]", "Sodium:neurotransmitter symporter [IPR000175]", "Solute carrier family 12 member 1/2 [IPR002443]", "Solute carrier family 12 member 2 [IPR002444]", "Solute carrier family 35 member SLC35F1/F2/F6 [IPR009262]", "Sorting nexin 9 family [IPR014536]", "Sorting nexin-1 [IPR028660]", "Sorting nexin-2 [IPR028653]", "Sorting nexin-5/6/32 [IPR014637]", "Sorting nexin-6 [IPR028657]", "Sorting nexin-9 [IPR028644]", "Spartin-like [IPR045036]", "Spectrin, beta subunit [IPR016343]", "Spermatid perinuclear RNA-binding protein [IPR030446]", "Spermidine/spermine synthase, eukaryotes [IPR030668]", "Spermidine/spermine synthases [IPR001045]", "Sphingomyelin phosphodiesterase 4 [IPR024129]", "Sphingosine N-acyltransferase Lag1/Lac1-like [IPR016439]", "Splicing factor 3A subunit 1 [IPR045146]", "Splicing factor 3A subunit 3 [IPR031776]", "Splicing factor 3B subunit 1-like [IPR038737]", "Splicing factor 45 [IPR040052]", "Splicing factor ELAV/Hu [IPR006548]", "Splicing factor, RBM39-like [IPR006509]", "Splicing factor, arginine/serine-rich 19 [IPR042841]", "Squalene cyclase [IPR018333]", "Squalene monooxygenase [IPR040125]", "Squalene synthase-like [IPR006449]", "Squalene/phytoene synthase [IPR002060]", "Stathmin family [IPR000956]", "Steroidogenic acute regulatory protein-like [IPR000799]", "Sterol transport protein NPC2-like [IPR039670]", "Stomatin/HflK/HflC family [IPR001972]", "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 [IPR038892]", "Structural maintenance of chromosomes protein 1A, metazoan [IPR029683]", "Structural maintenance of chromosomes protein [IPR024704]", "Structure-specific recognition protein [IPR000969]", "Succinate dehydrogenase, flavoprotein subunit [IPR011281]", "Succinate dehydrogenase/fumarate reductase iron-sulphur protein [IPR004489]", "Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [IPR014006]", "Succinate semialdehyde dehydrogenase [IPR010102]", "Succinate--CoA synthetase, beta subunit [IPR005809]", "Succinyl-CoA ligase, alpha subunit [IPR005810]", "Sulfhydryl oxidase [IPR039798]", "Sulfotransferase [IPR005331]", "Sulfurtransferase TST/MPST-like [IPR045078]", "Suppressor of white apricot [IPR040397]", "Surface antigen D15-like [IPR039910]", "Surfeit locus 6 [IPR007019]", "Symplekin/Pta1 [IPR021850]", "Synaptobrevin [IPR001388]", "Synaptogyrin [IPR016579]", "Syntaxin [IPR045242]", "Synthesis of cytochrome c oxidase, Sco1/Sco2 [IPR017276]", "T-complex protein 1, alpha subunit [IPR012715]", "T-complex protein 1, beta subunit [IPR012716]", "T-complex protein 1, delta subunit [IPR012717]", "T-complex protein 1, epsilon subunit [IPR012718]", "T-complex protein 1, eta subunit [IPR012720]", "T-complex protein 1, gamma subunit [IPR012719]", "T-complex protein 1, theta subunit [IPR012721]", "T-complex protein 1, zeta subunit [IPR012722]", "TAF15/EWS/TLS family [IPR034870]", "TAP46-like protein [IPR007304]", "TATA binding associated factor 15 [IPR034875]", "TB2/DP1/HVA22-related protein [IPR004345]", "TCF25/Rqc1 [IPR006994]", "TH1 protein [IPR006942]", "THO complex subunit 2 [IPR040007]", "THO complex subunit 6 [IPR042626]", "THO complex, subunit THOC1 [IPR021861]", "THRAP3/BCLAF1 family [IPR029199]", "TIP41-like protein [IPR007303]", "TMEM192 family [IPR029399]", "TMEM33/Pom33 family [IPR005344]", "TMEM85/ER membrane protein complex subunit 4 [IPR009445]", "TOX high mobility group box family member 4 [IPR037985]", "TPX2 [IPR009675]", "TRAPP I complex, subunit 5 [IPR016696]", "TREX component Tex1/THOC3 [IPR040132]", "Tankyrase 1-binding protein-like [IPR040006]", "Target of Myb protein 1 [IPR014645]", "Taxilin family [IPR026183]", "Telomere-associated protein Rif1 [IPR028566]", "Testis-expressed protein 10/pre-rRNA-processing protein Ipi1 [IPR037947]", "Tetrahydrofolate dehydrogenase/cyclohydrolase [IPR000672]", "Tetraspanin, animals [IPR000301]", "Tetraspanin/Peripherin [IPR018499]", "Tetratricopeptide repeat protein 19 [IPR040395]", "Tetratricopeptide repeat protein 21A/21B [IPR040364]", "Tetratricopeptide repeat protein 26 [IPR030511]", "Tetratricopeptide repeat protein 38 [IPR033891]", "ThiF/MoeB/HesA family [IPR045886]", "Thiamine pyrophosphate enzyme [IPR045229]", "Thiolase [IPR002155]", "Thioredoxin domain-containing protein 17-like [IPR045108]", "Thioredoxin-related transmembrane protein 2 [IPR039101]", "Thioredoxin/glutathione reductase selenoprotein [IPR006338]", "Threonine-tRNA ligase, class IIa [IPR002320]", "Thymidine kinase [IPR001267]", "Thymidylate kinase [IPR018094]", "Thymidylate synthase [IPR000398]", "Thymidylate synthase/dCMP hydroxymethylase [IPR045097]", "Thyroid hormone receptor-associated protein 3 [IPR026667]", "Tight junction protein ZO [IPR005417]", "Tight junction protein ZO-1 [IPR005418]", "Tight junction protein ZO-2 [IPR005419]", "Tim23-like [IPR045238]", "Tim44-like [IPR039544]", "Timeless [IPR044998]", "TmcA/NAT10/Kre33 [IPR032672]", "Tom40 [IPR037930]", "Torsin-1A-interacting protein 1/2 [IPR008662]", "TraB/PrgY/GumN family [IPR002816]", "Trans-isoprenyl diphosphate synthases, eukaryotic-type [IPR044844]", "Transaldolase type 1 [IPR004730]", "Transaldolase/Fructose-6-phosphate aldolase [IPR001585]", "Transcription elongation factor SPT5 [IPR039659]", "Transcription elongation factor Spt5, eukaryote [IPR017071]", "Transcription elongation factor Spt6 [IPR017072]", "Transcription elongation factor, IIS-type [IPR035100]", "Transcription elongation factor, TFIIS [IPR006289]", "Transcription elongation regulator 1-like [IPR045148]", "Transcription facto Tfc3-like [IPR044210]", "Transcription factor BTF3 [IPR039370]", "Transcription factor E [IPR039997]", "Transcription factor II-I [IPR016659]", "Transcription factor IIIC subunit Tfc1/Sfc1 [IPR040454]", "Transcription factor STAT [IPR001217]", "Transcription factor Tfc4/TFIIIC-102/Sfc4 [IPR039340]", "Transcription factor, enhancer of yellow 2 [IPR018783]", "Transcription intermediary factor 1-beta [IPR037373]", "Transcriptional regulator TACO1-like [IPR002876]", "Transcriptional regulatory protein Sin3-like [IPR039774]", "Transcriptional regulatory protein Sin3a [IPR037969]", "Transcriptional repressor p66 [IPR040386]", "Transducin beta-like protein 2 [IPR042410]", "Transferrin receptor protein 1 [IPR029513]", "Transgelin-2 [IPR001061]", "Translation Initiation factor eIF- 4e [IPR001040]", "Translation elongation factor EF1A, eukaryotic/archaeal [IPR004539]", "Translation elongation factor EFG/EF2 [IPR004540]", "Translation elongation factor EFTs/EF1B [IPR001816]", "Translation elongation factor EFTu/EF1A, bacterial/organelle [IPR004541]", "Translation elongation factor IF5A-like [IPR001884]", "Translation initiation factor 2, alpha subunit [IPR011488]", "Translation initiation factor 2A [IPR011387]", "Translation initiation factor 3 complex subunit L [IPR019382]", "Translation initiation factor IF- 2 [IPR015760]", "Translation initiation factor IF2/IF5 [IPR045196]", "Translation initiation factor IF6 [IPR002769]", "Translation initiation factor aIF-2, bacterial-like [IPR000178]", "Translational activator Gcn1 [IPR033173]", "Translationally controlled tumour protein [IPR018105]", "Translin [IPR033956]", "Translin family [IPR002848]", "Translocation associated membrane protein [IPR016447]", "Translocation protein Sec63 [IPR027137]", "Translocon-associated [IPR008855]", "Translocon-associated protein (TRAP), alpha subunit [IPR005595]", "Transmembrane emp24 domain-containing protein 7 [IPR015718]", "Transmembrane emp24 domain-containing protein [IPR015720]", "Transmembrane protein 109 [IPR039492]", "Transmembrane protein 126 [IPR009801]", "Transmembrane protein 201 [IPR040041]", "Transmembrane protein 205 [IPR042623]", "Transmembrane protein 214 [IPR019308]", "Transmembrane protein 230 [IPR044234]", "Transmembrane protein 230/134 [IPR008590]", "Transmembrane protein 43 family [IPR012430]", "Transmembrane protein 65 [IPR019537]", "Transmembrane protein GPR107/GPR108-like [IPR009637]", "Transport protein particle (TRAPP) component [IPR007194]", "Treacle protein [IPR017859]", "Tricarboxylate/iron carrier [IPR004686]", "Triosephosphate isomerase [IPR000652]", "Triosephosphate isomerase, bacterial/eukaryotic [IPR022896]", "Tropomodulin [IPR004934]", "Tropomodulin-3 [IPR030133]", "Tropomyosin [IPR000533]", "Tryptophan-tRNA ligase [IPR002306]", "Tuberin [IPR003913]", "Tuberin/Ral GTPase-activating protein subunit alpha [IPR027107]", "Tubulin [IPR000217]", "Tubulin binding cofactor A [IPR004226]", "Tubulin--tyrosine ligase-like protein 12 [IPR027749]", "Tubulin-specific chaperone E [IPR044994]", "Tubulin-tyrosine ligase/Tubulin polyglutamylase [IPR004344]", "Tumour protein D52 [IPR007327]", "Tweety [IPR006990]", "Twinfilin [IPR028458]", "Type 1 protein exporter [IPR039421]", "Type II pantothenate kinase [IPR004567]", "Tyrosine-tRNA ligase [IPR002307]", "Tyrosine-tRNA ligase, bacterial-type [IPR024088]", "U1 small nuclear ribonucleoprotein C [IPR017340]", "U2 small nuclear ribonucleoprotein A' [IPR044640]", "U2 snRNP auxilliary factor, large subunit, splicing factor [IPR006529]", "U3 small nucleolar RNA-associated protein 10 [IPR040191]", "U3 small nucleolar RNA-associated protein 18 [IPR045161]", "U3 small nucleolar RNA-associated protein 25 [IPR010678]", "U3 small nucleolar RNA-associated protein 6 [IPR013949]", "U3 small nucleolar ribonucleoprotein complex, subunit Mpp10 [IPR012173]", "U4/U6 small nuclear ribonucleoprotein Prp3 [IPR027104]", "U4/U6 small nuclear ribonucleoprotein Prp31 [IPR027105]", "U6 snRNA-associated Sm-like protein LSm2 [IPR016654]", "UAA transporter [IPR013657]", "UBAP2/protein lingerer [IPR022166]", "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110kDa subunit [IPR037919]", "UDP-glucose 6-dehydrogenase, eukaryotic type [IPR028356]", "UDP-glucose/GDP-mannose dehydrogenase [IPR017476]", "UDP-glucose:Glycoprotein Glucosyltransferase [IPR009448]", "UDP-sugar pyrophosphorylase [IPR039741]", "UDPGP family [IPR002618]", "UHRF1/2-like [IPR045134]", "UMP-CMP kinase [IPR006266]", "USP39 [IPR033809]", "UTP--glucose-1-phosphate uridylyltransferase [IPR016267]", "UV excision repair protein Rad23 [IPR004806]", "Ubiquitin carboxyl-terminal hydrolase 10 [IPR028767]", "Ubiquitin carboxyl-terminal hydrolase 14-like [IPR044635]", "Ubiquitin conjugation factor E4 [IPR045132]", "Ubiquitin fusion degradation protein Ufd1-like [IPR004854]", "Ubiquitin thioesterase OTUB1 [IPR030298]", "Ubiquitin thioesterase Otubain [IPR016615]", "Ubiquitin-activating enzyme E1 [IPR018075]", "Ubiquitin-fold modifier-conjugating enzyme 1 [IPR014806]", "Ubiquitin-like modifier Hub1/Ubl5 [IPR039732]", "Ubiquitin-protein ligase E3B/C [IPR044611]", "Ubiquitin/SUMO-activating enzyme E1 [IPR000011]", "Ubiquitinyl hydrolase [IPR016652]", "Ubiquitinyl hydrolase, UCH37 type [IPR017390]", "Uncharacterized protein KIAA2013-like [IPR018795]", "Uracil-DNA glycosylase family 1 [IPR002043]", "Ureohydrolase [IPR006035]", "Uroporphyrinogen decarboxylase HemE [IPR006361]", "V-type ATPase, V0 complex, 116kDa subunit family [IPR002490]", "V-type ATP synthase catalytic alpha chain [IPR022878]", "V-type ATP synthase regulatory subunit B/beta [IPR022879]", "V-type ATPase subunit E [IPR002842]", "V0 complex accessory subunit Ac45 [IPR008388]", "Vacuolar protein sorting protein 26 related [IPR028934]", "Vacuolar protein sorting-associated protein 13 [IPR026847]", "Vacuolar protein sorting-associated protein 16 [IPR016534]", "Vacuolar protein sorting-associated protein 29 [IPR028661]", "Vacuolar protein sorting-associated protein 33 [IPR027121]", "Vacuolar protein sorting-associated protein 35 [IPR005378]", "Vacuolar protein sorting-associated protein 4 [IPR031255]", "Vacuolar protein sorting-associated protein 51 [IPR014812]", "Vacuolar protein sorting-associated protein 53 [IPR039766]", "Vacuolar protein sorting-associated protein 9-like [IPR045046]", "Vacuolar protein sorting-associated protein Ist1 [IPR005061]", "Vacuolar protein-sorting protein Bro1-like [IPR045251]", "Valine-tRNA ligase [IPR002303]", "Vesicle-associated membrane-protein-associated protein [IPR016763]", "Vesicle-fusing ATPase [IPR039812]", "Vesicle-trafficking protein Sec22 [IPR044565]", "Villin/Gelsolin [IPR007122]", "Vimentin [IPR027699]", "Vinculin [IPR017997]", "Vinculin/alpha-catenin [IPR006077]", "Vitamin K-dependent gamma-carboxylase [IPR007782]", "Voltage-dependent anion-selective channel protein 1 [IPR030270]", "Voltage-dependent anion-selective channel protein 2 [IPR030277]", "Voltage-dependent anion-selective channel protein 3 [IPR030271]", "WD repeat BOP1/Erb1 [IPR028598]", "WD repeat Prp46/PLRG1-like [IPR045241]", "WD repeat WDR12/Ytm1 [IPR028599]", "WD repeat-containing protein 11 [IPR039694]", "WD repeat-containing protein 91 [IPR039724]", "WD repeat-containing protein DCAF7-like [IPR045159]", "WD repeat-containing protein WDR18/Ipi3/RID3 [IPR045227]", "WD repeat-containing protein WDR46/Utp7 [IPR040315]", "WD40 repeat-containing protein SMU1 [IPR045184]", "WW domain binding protein 11 [IPR019007]", "Wings apart-like protein [IPR039874]", "Wolframin [IPR026208]", "Wolframin family [IPR026209]", "XMAP215 family [IPR045110]", "XPG/Rad2 endonuclease [IPR006084]", "Xaa-Arg dipeptidase [IPR017144]", "YAP-binding/ALF4/Glomulin [IPR013877]", "YEATS [IPR005033]", "YLP motif-containing protein 1 [IPR026314]", "YTH domain containing protein [IPR045168]", "YjeF N-terminal domain-containing protein NAXE-like [IPR032976]", "Zinc finger CCCH domain-containing protein A/B [IPR039691]", "Zinc finger CCHC domain-containing protein 3 [IPR042509]", "Zinc finger FYVE domain containing protein, SARA/endofin [IPR035438]", "Zinc finger FYVE domain-containing protein, endofin [IPR017165]", "Zinc finger Ran-binding domain-containing protein 2 [IPR017337]", "Zinc finger protein 532-like [IPR045914]", "Zinc finger protein 638 [IPR033096]", "cAMP-dependent protein kinase catalytic subunit [IPR044109]", "cAMP-dependent protein kinase regulatory subunit [IPR012198]", "dCTP pyrophosphatase 1 [IPR025984]", "hnRNP A2/B1 [IPR034489]", "mRNA 3'-end-processing protein Rna14-like [IPR045243]", "mRNA export factor GLE1-like [IPR012476]", "mRNA export factor Gle2/RAE1 [IPR037631]", "p53 tumour suppressor family [IPR002117]", "rRNA biogenesis protein Rrp5 [IPR045209]", "tRNA (C5-cytosine) methyltransferase, NCL1 [IPR023270]", "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 [IPR017423]", "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit [IPR028884]", "tRNA (guanine-N1-)-methyltransferase, eukaryotic [IPR007356]", "tRNA methyltransferase 10 homologue C [IPR025812]", "tRNA modification GTPase MnmE [IPR004520]", "tRNA pseudouridine synthase B family [IPR004802]", "tRNA-specific 2-thiouridylase [IPR004506]", "tRNAHis guanylyltransferase Thg1 [IPR007537]"], "available_proteins": ["AAAS", "AARS", "AARS2", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABHD12", "ABHD6", "ACAA2", "ACADM", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSL1", "ACTL6A", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR6", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFG3L2", "AGL", "AGPS", "AHCY", "AHCYL1", "AHSA1", "AIMP2", "AIP", "AK1", "AK2", "AK6", "AKAP12", "AKAP13", "AKAP17A", "AKAP8L", "AKR1A1", "AKR1B1", "AKT1S1", "ALDH18A1", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALKBH5", "AMOT", "ANAPC1", "ANAPC16", "ANAPC5", "ANKLE2", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEX1", "API5", "APLP2", "APOL2", "APOO", "APP", "APRT", "ARCN1", "ARF4", "ARG2", "ARHGDIA", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARMC6", "ARMT1", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD3A", "ATAD3B", "ATG4B", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATPIF1", "ATXN2L", "B4GAT1", "BABAM1", "BABAM2", "BAIAP2", "BANF1", "BASP1", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCLAF1", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPTF", "BRCA1", "BRI3BP", "BRIX1", "BRMS1L", "BROX", "BSG", "BTF3", "BUB1B", "BUD23", "BYSL", "C12orf43", "C12orf73", "C15orf39", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C5orf15", "CAD", "CALD1", "CALR", "CALU", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBR1", "CBX3", "CCAR1", "CCAR2", "CCDC124", "CCDC47", "CCDC6", "CCDC86", "CCDC97", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD3EAP", "CDC123", "CDC37", "CDC42", "CDC73", "CDCA8", "CDIPT", "CDK5RAP3", "CDK6", "CDKAL1", "CEBPZ", "CECR2", "CENPB", "CENPI", "CEP170", "CERS2", "CFAP20", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHCHD3", "CHERP", "CHMP3", "CHMP7", "CHORDC1", "CHST14", "CIAPIN1", "CIP2A", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLGN", "CLIC1", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT10", "CNOT3", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG7", "COIL", "COLGALT1", "COMMD2", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "CORO1B", "CORO1C", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF2", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRNKL1", "CRTAP", "CS", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDB1", "DDOST", "DDRGK1", "DDX54", "DEK", "DENR", "DERL1", "DFFA", "DGCR8", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7", "DHX29", "DIABLO", "DIAPH1", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DKC1", "DLAT", "DLD", "DLST", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJC10", "DNAJC2", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPH2", "DPM1", "DPP3", "DPYSL2", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1I2", "DYNC1LI1", "DYNLL1", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI2", "ECSIT", "EDC4", "EEF1A2", "EEF1E1", "EEF1G", "EHD1", "EIF2A", "EIF2B1", "EIF2B2", "EIF2B4", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EMG1", "ENO1", "ENSA", "ENY2", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERGIC3", "ERH", "ERLIN2", "ERO1A", "ERP29", "ESD", "ESF1", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC3", "EZR", "F11R", "FADS2", "FAH", "FAM114A2", "FAM120B", "FAM162A", "FAM49B", "FAM8A1", "FAM98A", "FANCI", "FAR1", "FARSA", "FARSB", "FAU", "FBL", "FDFT1", "FDPS", "FECH", "FEN1", "FERMT2", "FH", "FHL1", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GALK1", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GBA", "GCAT", "GCN1", "GDI1", "GDI2", "GEMIN4", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GINS1", "GINS4", "GLA", "GLB1", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GM2A", "GNA13", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLGB1", "GOLIM4", "GORASP2", "GOT1", "GOT2", "GPAA1", "GPD2", "GPI", "GPR107", "GPR108", "GPRASP2", "GPS1", "GRIPAP1", "GRPEL1", "GRSF1", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAUS5", "HAX1", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDHD3", "HDHD5", "HEATR1", "HEBP1", "HECTD1", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIF1AN", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPC", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HOXA10", "HP1BP3", "HPF1", "HPRT1", "HPS6", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTRA2", "HTT", "HYOU1", "IARS", "IARS2", "ICMT", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IGBP1", "IK", "IKBIP", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMPDH2", "INA", "INCENP", "INF2", "INTS14", "INTS3", "IPO4", "IPO5", "IRGQ", "IRS4", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JPT2", "JUP", "KARS", "KDELR1", "KDM1A", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KIAA0368", "KIAA0391", "KIAA2013", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF5B", "KIFBP", "KLC2", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "LAMP1", "LAMTOR1", "LAMTOR2", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDAH", "LDHA", "LDHB", "LEMD3", "LETM1", "LGMN", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LNPEP", "LONP1", "LRPAP1", "LRPPRC", "LRRC47", "LSM12", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L3", "LYAR", "MACF1", "MAGED2", "MAGT1", "MAK16", "MAP1B", "MAP1S", "MAP4", "MAPRE1", "MAPRE2", "MARCKS", "MARCKSL1", "MARS", "MAT2A", "MAU2", "MBD3", "MBOAT7", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED16", "METAP2", "MFN1", "MFN2", "MGEA5", "MGST2", "MGST3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MINPP1", "MLEC", "MMAB", "MMGT1", "MMS19", "MOB4", "MOGS", "MORF4L1", "MOV10", "MPHOSPH10", "MPI", "MPST", "MPV17L2", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL53", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTBP", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTR", "MTX1", "MTX2", "MTX3", "MYBBP1A", "MYEF2", "MYG1", "NAA15", "NAA25", "NAA35", "NAA40", "NADK2", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NAT10", "NAXE", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCLN", "NCSTN", "NDC1", "NDRG3", "NDUFA4", "NDUFAF1", "NDUFAF7", "NDUFB11", "NDUFB4", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NELFCD", "NES", "NEU1", "NHP2", "NIP7", "NIPBL", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL11", "NOL6", "NOL7", "NOL9", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NPTN", "NSA2", "NSF", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT21", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUSAP1", "NUTF2", "NXF1", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL11", "OSBPL6", "OSBPL9", "OTUB1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PBDC1", "PBRM1", "PC", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6IP", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDS5A", "PDS5B", "PEBP1", "PECR", "PES1", "PEX14", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PHAX", "PHB", "PHB2", "PHF5A", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIGS", "PIGT", "PIN4", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PKM", "PLBD2", "PLEC", "PLIN3", "PLRG1", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "POLD1", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PPP6R3", "PPT1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF40A", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSAT1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PTBP1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTRH2", "PTRHD1", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RABGGTA", "RABL6", "RAC1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAD51AP1", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM10", "RBM17", "RBM22", "RBM26", "RBM27", "RBM39", "RBM45", "RBM5", "RBM8A", "RCC2", "RCL1", "RDH11", "RDH13", "RDX", "RECQL", "RECQL5", "REEP5", "REPS1", "RER1", "REXO2", "REXO4", "RFC1", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIF1", "RINT1", "RNASEH2A", "RNASET2", "RNF20", "RNF40", "RNPEP", "ROCK2", "RP2", "RPA1", "RPA3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP15", "RRP1B", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SAE1", "SAFB", "SAFB2", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SARS", "SARS2", "SART1", "SBDS", "SCAF1", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCD", "SCFD1", "SCO1", "SCPEP1", "SCRN1", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A3", "SF3B1", "SFSWAP", "SFXN1", "SGPL1", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A24", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC3A2", "SLC6A15", "SLC9A3R1", "SLFN11", "SLK", "SMARCA4", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMCHD1", "SMPD4", "SMU1", "SMYD3", "SND1", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SNX6", "SNX9", "SOD2", "SON", "SPAG9", "SPART", "SPCS2", "SPCS3", "SPR", "SPTBN1", "SQLE", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPRB", "SRRT", "SRSF10", "SRSF11", "SRSF2", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "SSU72", "STAG2", "STARD3", "STAT3", "STIP1", "STMN1", "STOML2", "STRBP", "STT3A", "STT3B", "STUB1", "STX12", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SURF6", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TACO1", "TAF15", "TAGLN2", "TALDO1", "TAMM41", "TAP1", "TAP2", "TARS", "TARS2", "TBCA", "TBCE", "TBL2", "TCEA1", "TCERG1", "TCF25", "TCOF1", "TCP1", "TECR", "TEX10", "TFG", "TFRC", "THG1L", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "TIGAR", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIPRL", "TJP1", "TJP2", "TK1", "TM9SF3", "TMCO1", "TMED10", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM126B", "TMEM192", "TMEM201", "TMEM205", "TMEM214", "TMEM230", "TMEM33", "TMEM43", "TMEM65", "TMEM97", "TMOD3", "TMX2", "TNKS1BP1", "TNPO1", "TOE1", "TOM1", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOX4", "TP53", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPP2", "TPT1", "TPX2", "TRABD", "TRAM1", "TRAP1", "TRAPPC5", "TRIM28", "TRIP12", "TRIP13", "TRMT10C", "TRMT6", "TRMU", "TROVE2", "TSC2", "TSFM", "TSN", "TSPAN6", "TSR1", "TSTA3", "TTC19", "TTC21B", "TTC26", "TTC37", "TTC38", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC9", "TXNRD1", "TYMS", "U2AF2", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE3C", "UBE4A", "UBL5", "UBR4", "UBR7", "UCHL5", "UFC1", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNG", "UPF1", "UPF3B", "UQCR10", "UQCRQ", "UROD", "USMG5", "USP10", "USP14", "USP39", "USP5", "USP9X", "UTP11", "UTP14A", "UTP18", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VPS13A", "VPS16", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4B", "VPS51", "VPS53", "WAPL", "WARS", "WBP11", "WDR11", "WDR12", "WDR18", "WDR33", "WDR4", "WDR46", "WDR82", "WDR91", "WFS1", "XAB2", "XPO1", "XPO4", "XPO5", "XPO7", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YEATS2", "YEATS4", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H14", "ZC3H7A", "ZCCHC3", "ZFYVE16", "ZMPSTE24", "ZNF326", "ZNF638", "ZNF687", "ZRANB2", "ZW10"], "leading_proteins": ["AARS2", "AK1", "AP2M1", "AP3M1", "APP", "ARL1", "ATP13A1", "ATP1B1", "ATP2B1", "ATP6V0A1", "CAPN2", "CHMP3", "CNDP2", "CNN3", "CPVL", "CRNKL1", "CTNNA1", "CTPS2", "DHCR7", "EIF3M", "EIF5", "FH", "FLNB", "FLNC", "FLOT1", "FMR1", "FUS", "G3BP1", "GDI2", "GLRX5", "GPR107", "GPS1", "HDAC1", "HDHD5", "HEXA", "ILKAP", "IPO4", "IPO5", "KPNA1", "KPNA2", "KPNA4", "KPNB1", "LNPEP", "LTA4H", "MAPRE2", "MRPL3", "MSH3", "MSH6", "MTIF2", "NAP1L1", "NUCB1", "P4HA2", "PDS5B", "PLS1", "PRKAR1A", "PSMB2", "PSMB6", "PTRH2", "PYGL", "RAB24", "RABL6", "RALA", "RANBP1", "RARS2", "RBM27", "RHOG", "RPS5", "RRP1B", "RUVBL2", "SARS2", "SCAMP2", "SCARB2", "SCPEP1", "SEPT2", "SEPT7", "SET", "TAF15", "TIMM17B", "TJP2", "TMED9", "TSR1", "TUBB4B", "TUBB6", "UBA3", "VARS2", "VDAC1", "VDAC2", "XAB2", "YWHAQ"]} \ No newline at end of file diff --git a/interpro_homologous_superfamily/advanced/idx2term.json b/interpro_homologous_superfamily/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..8b558f188237c7b6b8d0b48c20eee75db3f9650d --- /dev/null +++ b/interpro_homologous_superfamily/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Glycoside hydrolase superfamily [IPR017853]", "1": "Immunoglobulin-like fold [IPR013783]"} \ No newline at end of file diff --git a/interpro_homologous_superfamily/advanced/plot_0.png b/interpro_homologous_superfamily/advanced/plot_0.png new file mode 100644 index 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sha256:7d0cd2280d11e008ada5e4fccdd23099bcfd388c7cee9b6113456fb446981712 +size 150922 diff --git a/interpro_homologous_superfamily/consensus.joblib b/interpro_homologous_superfamily/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..4bef73e9fd546404aed0dc437c7b175061401a55 --- /dev/null +++ b/interpro_homologous_superfamily/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:f69d56922d3120177c856bf0f3d5a56e90296d3433d2063b80d5f2dd054352db +size 209200 diff --git a/interpro_homologous_superfamily/df_merge.tsv b/interpro_homologous_superfamily/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..acea3c88b1e2dadd61c612415e6cce7f2c8439b3 --- /dev/null +++ b/interpro_homologous_superfamily/df_merge.tsv @@ -0,0 +1,6 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 +Glycoside hydrolase superfamily [IPR017853] 9 14 2.8374892011205044 0.00454698849024 7.094660194174757 15.565533980582524 0.5992585613623983 0.1928722204186086 2.565315823223627 1.245604487832095 1.9386029676344616 0.2695693578719223 2.1801582288281967e-09 1.584453152491889e-12 2.37480925355545e-10 1.8490177010115665e-07 +Immunoglobulin-like fold [IPR013783] 6 20 2.352073504908965 0.0186690853213107 9.024271844660197 30.70631067961165 -0.0882371106398617 0.5574652875269992 4.075666983819175 5.992200349595445 1.1066442573771362 0.3307702752839019 1.0 0.1794134798201282 0.3112021391919369 0.865386202290488 +Immunoglobulin E-set [IPR014756] 1 10 2.185175057061762 0.0288760136303796 3.4563106796116503 15.148058252427184 0.2670321239563391 0.4966749963270377 2.426698980572813 2.6319399461427304 0.9943374164221532 0.3081935983105719 0.2412174988663298 0.1043706933170995 0.3988408250989342 0.7661546402852099 +Galactose-binding-like domain superfamily [IPR008979] 2 9 2.124449533596616 0.0336325717707282 3.0266990291262137 10.45388349514563 0.2272915730277323 0.4946686484554474 2.0113188873716883 2.8129916124420524 1.0072294248002038 0.3052099564304033 0.2222355866483168 0.0135653143077038 0.1279773017110395 0.2373860395762566 +Glycosyl hydrolase, all-beta [IPR013780] 3 5 2.018367044436322 0.043553048958373 3.628640776699029 7.919902912621359 0.108448733903935 0.2677010542317815 1.6191976609214136 0.9906808437954988 1.5895506376095985 0.2857304479214345 3.066034551708988e-05 0.0002437892001771 0.0002086676392486 0.0028246814840344 diff --git a/interpro_homologous_superfamily/metrics.json b/interpro_homologous_superfamily/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..087bc09c49fdf7a774c776219bf1aa7ff822d48e --- /dev/null +++ b/interpro_homologous_superfamily/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2453, + "annotations_size": 866, + "title": "Average number of proteins per term", + "value": 4.362586605080831 +} \ No newline at end of file diff --git a/interpro_homologous_superfamily/paths.json b/interpro_homologous_superfamily/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..b55a999b868f304740afc40a72e6325a6428b67a --- /dev/null +++ b/interpro_homologous_superfamily/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_homologous_superfamily/fragment/C334/C334_val_log2fc"} \ No newline at end of file diff --git a/interpro_homologous_superfamily/result.tsv b/interpro_homologous_superfamily/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..dd6236f0bf80effa2fc05a0e36d1320fee675387 --- /dev/null +++ b/interpro_homologous_superfamily/result.tsv @@ -0,0 +1,117 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Glycoside hydrolase superfamily [IPR017853] 0.9195469029226122 2.8374892011205044 0.00454698849024 0.9806811037742812 0.0194935249136033 14 P06865,P06280,P07686,Q9BTY2,P10253,P04062,P54802,P08236,P16278 9 +Amyloidogenic glycoprotein, copper-binding domain superfamily [IPR036669] 0.9885760913912692 2.6753035812734915 0.0074661608491912 0.9984813797293232 0.0287841379846117 2 P05067 1 +Amyloidogenic glycoprotein, heparin-binding domain superfamily [IPR036454] 0.9885760913912692 2.6753035812734915 0.0074661608491912 0.9984813797293232 0.0287841379846117 2 P05067 1 +Pancreatic trypsin inhibitor Kunitz domain superfamily [IPR036880] 0.9885760913912692 2.6753035812734915 0.0074661608491912 0.9984813797293232 0.0287841379846117 2 P05067 1 +E2 domain superfamily [IPR036176] 0.9885760913912692 2.6753035812734915 0.0074661608491912 0.9984813797293232 0.0287841379846117 2 P05067 1 +Ricin B-like lectins [IPR035992] 0.9273765809873532 2.422420260872322 0.0154175089334804 0.9999985667370468 0.0483358474004125 2 Q10472 1 +Immunoglobulin-like fold [IPR013783] 0.7223737360278444 2.352073504908965 0.0186690853213107 0.9999999183029902 0.0546196888116726 20 P10321,Q92692,Q9Y624,Q15375,P08236,P35613 6 +Sodium/potassium-transporting ATPase subunit beta superfamily [IPR038702] 0.8755609955120367 2.203069076606237 0.0275898803448271 0.999999999969964 0.0736314877503533 2 P05026 1 +Immunoglobulin E-set [IPR014756] 0.8207350302776342 2.185175057061762 0.0288760136303796 0.9999999999904527 0.0767074472512538 10 P61916 1 +Beta-hexosaminidase-like, domain 2 [IPR029018] 0.979591836734694 2.170744228687721 0.0299505118754304 0.9999999999963396 0.0790766563540327 3 P06865,P07686 2 +Galactose-binding-like domain superfamily [IPR008979] 0.8182445484453175 2.124449533596616 0.0336325717707282 0.999999999999864 0.0834419191007545 9 Q15375,P16278 2 +CRIB domain superfamily [IPR036936] 0.840065279477764 2.0501260398653645 0.0403521329213796 0.9999999999999996 0.0970692975275409 2 Q13177 1 +Glycosyl hydrolase, all-beta [IPR013780] 0.9370824427436928 2.018367044436322 0.043553048958373 1.0 0.1022139306177536 5 P06280,P10253,Q9BTY2 3 +NAP-like superfamily [IPR037231] 0.9306122448979588 1.9862834701665395 0.0470018570168875 1.0 0.1082542770654909 3 P55209,Q01105 2 +Immunoglobulin-like domain superfamily [IPR036179] 0.7712142573189515 1.9322097077245015 0.0533336274731239 1.0 0.1184280035685265 9 P10321,Q92692,Q9Y624,P35613 4 +EB1, C-terminal domain superfamily [IPR036133] 0.7992656058751539 1.8718288634275304 0.061230283699428 1.0 0.1305454156079753 2 Q15555 1 +Translation initiation factor IF2/IF5, N-terminal [IPR016189] 0.7968176254590006 1.8610521262452229 0.062736815896746 1.0 0.1319307637121775 2 P55010 1 +Translation initiation factor IF2/IF5, zinc-binding [IPR016190] 0.7968176254590006 1.8610521262452229 0.062736815896746 1.0 0.1319307637121775 2 P55010 1 +Peptidyl-tRNA hydrolase II domain superfamily [IPR023476] 0.7927376580987358 1.843072238905229 0.0653184639598656 1.0 0.1353248559551283 2 Q9Y3E5 1 +Ubiquitin activating enzyme, alpha domain superfamily [IPR023318] 0.7874337005304022 1.819664165288097 0.0688101636325977 1.0 0.1412075869806389 2 Q8TBC4 1 +Histone deacetylase domain superfamily [IPR037138] 0.7768257853937219 1.7727359328011207 0.0762724739474052 1.0 0.1532528130822573 2 Q13547 1 +Sterile alpha motif/pointed domain superfamily [IPR013761] 0.8525146093821727 1.6827709157853008 0.0924194473622765 1.0 0.1759016294851242 4 Q15375 1 +L27 domain superfamily [IPR036892] 0.7372501019991827 1.5964925149998066 0.1103788755717178 1.0 0.1988655971980014 2 Q9NZW5 1 +MHC class I-like antigen recognition-like superfamily [IPR037055] 0.8285714285714267 1.592957716481764 0.1111696770287329 1.0 0.1989574754838234 3 P10321,P01889 2 +MHC classes I/II-like antigen recognition protein [IPR011162] 0.8285714285714267 1.592957716481764 0.1111696770287329 1.0 0.1989574754838234 3 P10321,P01889 2 +CAP Gly-rich domain superfamily [IPR036859] 0.7364341085271374 1.5928420332034747 0.1111956329493886 1.0 0.1989574754838234 2 Q14203 1 +K Homology domain, type 1 superfamily [IPR036612] 0.5592683975280456 1.5867688822450825 0.1125649989671602 1.0 0.2005787841678204 23 O75179,Q06787,Q8IWZ3,Q9NRX1,P51114,Q92667,Q96PU8 7 +Translation initiation factor IF-2, domain 3 superfamily [IPR036925] 0.7070583435332558 1.4611027774659884 0.1439872381238318 1.0 0.2425932844654443 2 P46199 1 +PH-like domain superfamily [IPR011993] 0.4846621474406556 1.4232912223585572 0.1546517504699631 1.0 0.2565678465651113 38 P05067,Q12802,Q9NVZ3,Q8NC96,P31751,P43487,Q06481 7 +PIN-like domain superfamily [IPR029060] 0.7823804210863898 1.4137196388347897 0.1574442367588591 1.0 0.2585644336895484 4 Q9UQ84 1 +FAD/NAD(P)-binding domain superfamily [IPR036188] 0.5794204577429057 1.3984670856544603 0.1619728499669863 1.0 0.2621840898531031 16 Q8NCN5,O95831,Q8NB78 3 +Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097] 0.7622076817904524 1.353212158742935 0.1759878620205497 1.0 0.2751001597649748 6 Q9UIQ6 1 +Peptidase M4/M1, CTD superfamily [IPR027268] 0.7622076817904524 1.353212158742935 0.1759878620205497 1.0 0.2751001597649748 6 Q9UIQ6 1 +Chaperone J-domain superfamily [IPR036869] 0.5892283177580224 1.346776535229231 0.1780522141300569 1.0 0.2778256170029356 14 Q99615,Q96KC8,Q8IXB1,Q99543,O60884,Q13217,P25685,Q8WXX5 8 +Calpain large subunit, domain III superfamily [IPR036213] 0.6658506731946174 1.2758021665712502 0.202025461510567 1.0 0.3032132576571075 2 P17655 1 +Mitochondrial carrier domain superfamily [IPR023395] 0.5351458119158323 1.2475264634876817 0.2122045231105751 1.0 0.3173905302482868 18 Q9H2D1,O43772,O43808,Q9BSK2 4 +SKP1/BTB/POZ domain superfamily [IPR011333] 0.7211322741593221 1.1990968286369148 0.2304902971137132 1.0 0.3435535237529702 6 Q08380 1 +Leucine-rich repeat domain superfamily [IPR032675] 0.5050517840325717 1.19767703635578 0.2310427725222701 1.0 0.3437852938217971 21 Q9NYL9,Q9ULM6,Q9Y2I1,O94813,Q9Y2K7,Q92696,Q92688 7 +Alpha/Beta hydrolase fold [IPR029058] 0.5025237771749184 1.1559416032395535 0.2477050439970087 1.0 0.3673160412695369 20 Q9HB40,P10619,P50897,P38571,Q9H3G5 5 +Class I glutamine amidotransferase-like [IPR029062] 0.6174017240194641 1.1109422985273818 0.2665931870096489 1.0 0.391304576187044 8 Q92820,Q9NRF8 2 +FAD/NAD-linked reductase, dimerisation domain superfamily [IPR016156] 0.7033027255521554 1.1086125606403148 0.2675973571752468 1.0 0.3920732633961826 4 O95831 1 +BRO1 domain superfamily [IPR038499] 0.6283149734802145 1.1076283156787967 0.2680223694348038 1.0 0.3920732633961826 2 Q5VW32 1 +Ubiquitin-conjugating enzyme/RWD-like [IPR016135] 0.5613667551351516 1.0661019493989878 0.2863775585013239 1.0 0.4161123584935345 10 P49427 1 +Ankyrin repeat-containing domain superfamily [IPR036770] 0.5388919668780916 1.0630870352849136 0.2877424832867468 1.0 0.4173952940139409 13 Q8IWZ3,O75179 2 +Nucleophile aminohydrolases, N-terminal [IPR029055] 0.5005586234060709 1.0605060236196506 0.2889144510536523 1.0 0.4183945060409078 18 P28072,P49721 2 +Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400] 0.6400098054735706 1.0444816946986426 0.2962625840229429 1.0 0.4253866555340722 7 Q8WUJ1 1 +L-Aspartase-like [IPR008948] 0.6128110975112225 1.0386982243072451 0.298945107265685 1.0 0.4274070551408345 2 P07954 1 +Translation elongation factor eEF-1beta-like superfamily [IPR036219] 0.6119951040391707 1.035083071896298 0.3006301174293593 1.0 0.428200134364844 2 P29692 1 +Translation elongation factor EF1B/ribosomal protein S6 [IPR014717] 0.6119951040391707 1.035083071896298 0.3006301174293593 1.0 0.428200134364844 2 P29692 1 +Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily [IPR037151] 0.6030191758465964 0.9954150852144652 0.3195344247240415 1.0 0.449946035465073 2 Q6P6C2 1 +SNF2-like, N-terminal domain superfamily [IPR038718] 0.541449038276413 0.948014674591644 0.3431219836609385 1.0 0.4774389507178311 9 Q2NKX8,Q9H4L7,Q14527 3 +Concanavalin A-like lectin/glucanase domain superfamily [IPR013320] 0.4954952001238409 0.9260849354128668 0.3544018421901724 1.0 0.4871618973598244 15 Q12899,O94813 2 +Tubulin/FtsZ-like, C-terminal domain [IPR037103] 0.6472842267532041 0.8953518470013279 0.3705990328579616 1.0 0.504620695683954 4 Q9BUF5,P68371 2 +Tubulin, C-terminal [IPR023123] 0.6472842267532041 0.8953518470013279 0.3705990328579616 1.0 0.504620695683954 4 Q9BUF5,P68371 2 +Tubulin/FtsZ, C-terminal [IPR008280] 0.6472842267532041 0.8953518470013279 0.3705990328579616 1.0 0.504620695683954 4 Q9BUF5,P68371 2 +Tubulin/FtsZ, GTPase domain superfamily [IPR036525] 0.6472842267532041 0.8953518470013279 0.3705990328579616 1.0 0.504620695683954 4 Q9BUF5,P68371 2 +P-type ATPase, A domain superfamily [IPR008250] 0.6338890394308648 0.8748449833693627 0.3816582575236689 1.0 0.5140218522791559 5 P20020,Q9HD20 2 +P-type ATPase, cytoplasmic domain N [IPR023299] 0.6338890394308648 0.8748449833693627 0.3816582575236689 1.0 0.5140218522791559 5 P20020,Q9HD20 2 +P-type ATPase, transmembrane domain superfamily [IPR023298] 0.6338890394308648 0.8748449833693627 0.3816582575236689 1.0 0.5140218522791559 5 P20020,Q9HD20 2 +UBA-like superfamily [IPR009060] 0.4840522326553473 0.8343334117522266 0.4040931289541154 1.0 0.5367249228132882 14 Q13501,Q14157,Q9Y5A7,Q7Z6Z7 4 +EF-hand domain pair [IPR011992] 0.3955073108862504 0.8123963907208668 0.4165642165973446 1.0 0.5507551321729778 42 Q02818,Q9Y680,P80303,Q9BRK5,Q9NWM8,Q14257,O43852 7 +PurM-like, N-terminal domain superfamily [IPR036921] 0.6233222713705466 0.7953591885191128 0.4264045927390221 1.0 0.561195102297862 3 P49903 1 +PurM-like, C-terminal domain superfamily [IPR036676] 0.6233222713705466 0.7953591885191128 0.4264045927390221 1.0 0.561195102297862 3 P49903 1 +PDZ superfamily [IPR036034] 0.467121392417524 0.7531135507235655 0.451381682199842 1.0 0.58590406286147 14 Q6ZWJ1,Q07157,Q9NZW5,Q9UDY2,Q96HC4,O43464,Q9H8Y8 7 +14-3-3 domain superfamily [IPR036815] 0.599906925792536 0.7512313710685726 0.4525134234476908 1.0 0.58590406286147 6 P27348 1 +Endonuclease/exonuclease/phosphatase superfamily [IPR036691] 0.6046428436030928 0.7377228130516789 0.4606829062272013 1.0 0.5919160189803506 4 Q9ULM6 1 +Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily [IPR018163] 0.5647494754473591 0.6278246649659075 0.5301188064575548 1.0 0.6580980709873726 6 Q9BW92 1 +Translation protein, beta-barrel domain superfamily [IPR009000] 0.4194601781017711 0.6273496187531733 0.5304300849297761 1.0 0.6580980709873726 18 Q9BTE6,Q05639,Q9Y450,O00178,P46199,O60841,P18077,Q7Z2Z2,P49411 9 +Beta-grasp domain superfamily [IPR012675] 0.5162299360880365 0.5758973154243707 0.5646845902872646 1.0 0.6966052068216113 7 Q9BW92,P55039 2 +Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal [IPR009001] 0.5487049382278106 0.5700102603026466 0.5686707390768213 1.0 0.6985373901284074 5 Q05639,O00178,P49411 3 +Ribosomal protein S7 domain superfamily [IPR036823] 0.4985720114239117 0.5586668312686626 0.5763891201219409 1.0 0.7020435696562599 2 P46782 1 +K homology domain-like, alpha/beta [IPR015946] 0.49449204406365 0.5430785098014244 0.5870757482840736 1.0 0.7120554594033721 2 P23396 1 +K homology domain superfamily, prokaryotic type [IPR009019] 0.49449204406365 0.5430785098014244 0.5870757482840736 1.0 0.7120554594033721 2 P23396 1 +TGS-like [IPR012676] 0.5280237776655407 0.5051640478422367 0.6134436194938293 1.0 0.73375990950505 6 Q9BW92,P55039 2 +Homeobox-like domain superfamily [IPR009057] 0.3905771539555921 0.462113133232796 0.6440001925676511 1.0 0.76189093820162 17 Q8NB78,Q96G23 2 +Prefoldin [IPR009053] 0.5213827003413534 0.4539503373610861 0.6498645719530374 1.0 0.7667339500154364 4 Q99471 1 +Ubiquitin-activating enzyme [IPR035985] 0.5071268664843234 0.4350045223410287 0.6635591448736249 1.0 0.7797045040170408 5 Q8TBC4 1 +Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm [IPR010978] 0.461036311709507 0.4216990392003851 0.6732447058444033 1.0 0.7824048358940247 2 Q9NP81 1 +Serine-tRNA synthetase, type1, N-terminal domain superfamily [IPR042103] 0.461036311709507 0.4216990392003851 0.6732447058444033 1.0 0.7824048358940247 2 Q9NP81 1 +Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily [IPR018162] 0.4606283149734817 0.420297181290826 0.6742683687827462 1.0 0.7824048358940247 2 Q5JTZ9 1 +Death-like domain superfamily [IPR011029] 0.5121798214467764 0.4139818246669011 0.6788874176866697 1.0 0.7858786296750109 3 Q13546 1 +PWI domain superfamily [IPR036483] 0.5115264157987961 0.4120055772897506 0.6803353353010688 1.0 0.7858786296750109 3 O43395 1 +HSP20-like chaperone [IPR008978] 0.4089546372894876 0.4091551788022192 0.6824257846600557 1.0 0.7858786296750109 9 Q15185,Q8WVJ2,Q96RS6 3 +HSP40/DnaJ peptide-binding [IPR008971] 0.5057341256468096 0.4059744990255836 0.684761337644068 1.0 0.7874061326124243 4 O60884,P25685 2 +ArfGAP domain superfamily [IPR038508] 0.455732354141166 0.40363663408966 0.6864799424045962 1.0 0.7874061326124243 2 Q8N6T3 1 +ARFGAP/RecO-like zinc finger [IPR037278] 0.455732354141166 0.40363663408966 0.6864799424045962 1.0 0.7874061326124243 2 Q8N6T3 1 +NAD kinase/diacylglycerol kinase-like domain superfamily [IPR016064] 0.4532843737250099 0.3954203239505963 0.692532712297746 1.0 0.7912049193269763 2 Q53H12 1 +Inorganic polyphosphate/ATP-NAD kinase, N-terminal [IPR017438] 0.4532843737250099 0.3954203239505963 0.692532712297746 1.0 0.7912049193269763 2 Q53H12 1 +Six-hairpin glycosidase superfamily [IPR008928] 0.4508363933088633 0.3872816517774479 0.6985477075210962 1.0 0.7966822483725057 2 P35573 1 +Zinc finger, RanBP2-type superfamily [IPR036443] 0.3969663249212936 0.3664837289251629 0.7140041518043803 1.0 0.8094037490572332 9 P35637,Q92804 2 +Chromo-like domain superfamily [IPR016197] 0.4795689908611876 0.353072196799841 0.7240343160256923 1.0 0.8118897499125048 5 Q13185,P83916 2 +PPM-type phosphatase domain superfamily [IPR036457] 0.431660546715627 0.3263530009694156 0.7441572923142696 1.0 0.8260165657037861 2 Q9H0C8 1 +Arginyl tRNA synthetase N-terminal domain superfamily [IPR036695] 0.4275805793553642 0.3140684388343496 0.7534690597378884 1.0 0.8333387046398613 2 Q5T160 1 +Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 [IPR042449] 0.4702040816326475 0.2958784998757562 0.7673228709356785 1.0 0.8443476572176589 3 Q9UBT2,P22314 2 +Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily [IPR038502] 0.4145246838025315 0.2764610776086914 0.7821939506516264 1.0 0.8555951393551704 2 P09960 1 +AP-2 complex subunit mu, C-terminal superfamily [IPR036168] 0.4495343346819461 0.253517007836491 0.7998687200010806 1.0 0.8697921546971432 4 P48444 1 +Six-bladed beta-propeller, TolB-like [IPR011042] 0.4291137470867961 0.207073312314379 0.8359526040611038 1.0 0.8948516132471148 4 Q15165 1 +Nucleotide-diphospho-sugar transferases [IPR029044] 0.3361442678114989 0.195582119196228 0.8449372567954598 1.0 0.9000192673860617 14 O60568,Q10472,Q10471 3 +Importin-alpha, importin-beta-binding domain superfamily [IPR036975] 0.401388321763988 0.1525888666672217 0.8787225052914058 1.0 0.929606066358832 4 P52294,O00629,P52292 3 +Creatinase/Aminopeptidase P/Spt16, N-terminal [IPR029149] 0.3995918367346877 0.1450599739838053 0.8846635200929112 1.0 0.9339547988855924 3 Q9NQW7,Q9Y5B9 2 +S-adenosyl-L-methionine-dependent methyltransferase [IPR029063] 0.3080048975397528 0.1408277666783939 0.8880060070231917 1.0 0.9339547988855924 23 Q8N1G2,Q9BV86,Q6FI81,Q99873 4 +DNA mismatch repair protein MutS, core domain superfamily [IPR036187] 0.3963265306122401 0.1396936362429354 0.8889020546466575 1.0 0.9339547988855924 3 P52701,P20585 2 +DNA mismatch repair protein MutS, N-terminal [IPR016151] 0.3963265306122401 0.1396936362429354 0.8889020546466575 1.0 0.9339547988855924 3 P52701,P20585 2 +MutS, connector domain superfamily [IPR036678] 0.3963265306122401 0.1396936362429354 0.8889020546466575 1.0 0.9339547988855924 3 P52701,P20585 2 +RuvBL1/2, DNA/RNA binding domain [IPR042487] 0.348837209302327 0.1303831672776691 0.8962632834708288 1.0 0.9385296293660674 2 Q9Y230 1 +Ribosomal protein S5 domain 2-type fold, subgroup [IPR014721] 0.3084415483602722 0.1065057325170652 0.915181107389892 1.0 0.944834827254496 12 Q02880,Q7Z2Z2 2 +Isoprenoid synthase domain superfamily [IPR008949] 0.3312933496531987 0.1040053725202826 0.9171650850411296 1.0 0.9455535281495454 2 P14324 1 +RmlC-like cupin domain superfamily [IPR011051] 0.3617803184973405 0.0924552757439103 0.9263363237511064 1.0 0.950482531242249 4 O00625,P38435,Q9BV57 3 +SNase-like, OB-fold superfamily [IPR035437] 0.3571428571428517 0.0864341284048414 0.9311213178924804 1.0 0.953798054850174 3 Q92667,Q9Y2W6 2 +LEM/LEM-like domain superfamily [IPR011015] 0.3521255113482222 0.0856176263036397 0.9317703861469366 1.0 0.953798054850174 5 Q9Y2U8 1 +Creatinase/aminopeptidase-like [IPR036005] 0.3488562091503286 0.0815041853445041 0.935040996531197 1.0 0.9560159421440574 5 P12955,P50579,Q9NQW7,Q9Y5B9 4 +Tetratricopeptide-like helical domain superfamily [IPR011990] 0.285982299083335 0.0375950422020856 0.970010560878798 1.0 0.9871082793431716 82 Q9BZJ0,Q92791,Q9UJX2,P13674,O75153,Q15020,Q5R3I4,Q9Y262,Q13217,Q99614,Q99747,Q9H9A5,O00170,Q9Y5A7,Q32P28,Q6DKK2,Q9NSK0,Q96EK5,P42345,Q9H7B4,O43242,O15460 22 +HotDog domain superfamily [IPR029069] 0.2964475296039271 0.0353984410505629 0.971762027795816 1.0 0.987729948440348 4 Q9Y305,O00154,P51659 3 +DNA/RNA polymerase superfamily [IPR043502] 0.2465306122448921 0.0253643084009294 0.9797643797128316 1.0 0.9946963104704716 3 Q07864,O00411 2 +Phosphoribosyltransferase-like [IPR029057] 0.2693093583980432 0.013321751730667 0.9893710943558468 1.0 1.0 6 P00492,O60256,Q06203,Q14558,P07741 5 +Histidine kinase/HSP90-like ATPase superfamily [IPR036890] 0.2541825927012237 0.010673770912999 0.9914837246922804 1.0 1.0 8 Q02880 1 diff --git a/interpro_homologous_superfamily/selections.json b/interpro_homologous_superfamily/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..15b7689de266a29a053270eb2ef6df132d9da480 --- /dev/null +++ b/interpro_homologous_superfamily/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 domain superfamily [IPR036815]", "2Fe-2S ferredoxin-like superfamily [IPR036010]", "30s ribosomal protein S13, C-terminal [IPR027437]", "4'-phosphopantetheinyl transferase domain superfamily [IPR037143]", "5'-3' exonuclease, C-terminal domain superfamily [IPR036279]", "50S ribosomal protein L10, insertion domain superfamily [IPR043164]", "50S ribosomal protein L30e-like [IPR029064]", "6-phosphogluconate dehydrogenase, domain 2 [IPR013328]", "6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily [IPR008927]", "ABC transporter type 1, transmembrane domain superfamily [IPR036640]", "ACP-like superfamily [IPR036736]", "ADF-H/Gelsolin-like domain superfamily [IPR029006]", "ADP-ribosylation/Crystallin J1 superfamily [IPR036705]", "AF1104-like superfamily [IPR036075]", "AH/BAR domain superfamily [IPR027267]", "AICAR transformylase, duplicated domain superfamily [IPR024051]", "AICAR transformylase, insert domain superfamily [IPR024050]", "AMP-binding enzyme, C-terminal domain superfamily [IPR045851]", "ANL, N-terminal domain [IPR042099]", "ANTH domain superfamily [IPR014712]", "AP-2 complex subunit mu, C-terminal superfamily [IPR036168]", "ARFGAP/RecO-like zinc finger [IPR037278]", "ARID DNA-binding domain superfamily [IPR036431]", "ATP synthase subunit alpha, N-terminal domain-like superfamily [IPR023366]", "ATP synthase, F0 complex, subunit D superfamily, mitochondrial [IPR036228]", "ATP synthase, F1 complex, gamma subunit superfamily [IPR035968]", "ATP synthase, alpha subunit, C-terminal domain superfamily [IPR038376]", "ATP-NAD kinase, PpnK-type, C-terminal [IPR017437]", "ATP-grasp fold, subdomain 1 [IPR013815]", "ATP:guanido phosphotransferase, N-terminal domain superfamily [IPR036802]", "ATPase, F1/V1 complex, beta/alpha subunit, C-terminal [IPR024034]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily [IPR036121]", "ATPase, V1 complex, subunit H, C-terminal domain superfamily [IPR038497]", "ATPase, nucleotide binding domain [IPR043129]", "Acetylglutamate kinase-like superfamily [IPR036393]", "Aconitase, domain 2 [IPR015932]", "Aconitase, iron-sulfur domain [IPR036008]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 [IPR015931]", "Aconitase/3-isopropylmalate dehydratase, swivel [IPR015928]", "Actin-crosslinking [IPR008999]", "Actin-related protein 2/3 complex subunit 3 superfamily [IPR036753]", "Activator of Hsp90 ATPase, Aha1 [IPR036338]", "Acyl transferase domain superfamily [IPR001227]", "Acyl transferase/acyl hydrolase/lysophospholipase [IPR016035]", "Acyl-CoA N-acyltransferase [IPR016181]", "Acyl-CoA binding protein superfamily [IPR035984]", "Acyl-CoA dehydrogenase-like, C-terminal [IPR036250]", "Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily [IPR009100]", "Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily [IPR037069]", "Adenine nucleotide alpha hydrolase-like domains [IPR023382]", "Adenosylhomocysteinase-like superfamily [IPR042172]", "Adenylate cyclase-associated CAP, C-terminal superfamily [IPR036223]", "Adenylate cyclase-associated CAP, N-terminal domain superfamily [IPR036222]", "Adenylosuccinate synthetase, domain 1 [IPR042109]", "Adenylosuccinate synthetase, domain 2 [IPR042110]", "Adenylosuccinate synthetase, domain 3 [IPR042111]", "Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily [IPR018162]", "Aldehyde dehydrogenase, C-terminal [IPR016163]", "Aldehyde dehydrogenase, N-terminal [IPR016162]", "Aldehyde/histidinol dehydrogenase [IPR016161]", "Aldolase-type TIM barrel [IPR013785]", "Alkaline-phosphatase-like, core domain superfamily [IPR017850]", "Allosteric substrate binding domain superfamily [IPR029009]", "Alpha-D-phosphohexomutase, C-terminal domain superfamily [IPR036900]", "Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III [IPR016055]", "Alpha-catenin/vinculin-like superfamily [IPR036723]", "Alpha-glycerophosphate oxidase, C-terminal domain superfamily [IPR038299]", "Alpha-helical ferredoxin [IPR009051]", "Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily [IPR036784]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily [IPR037151]", "Alpha/Beta hydrolase fold [IPR029058]", "Alpha/beta knot methyltransferases [IPR029028]", "Amidase signature (AS) superfamily [IPR036928]", "Aminoacyl-tRNA synthetase, class Ia, anticodon-binding [IPR009080]", "Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097]", "Aminotransferase-like, PLP-dependent enzymes [IPR036038]", "Amyloidogenic glycoprotein, amyloid-beta peptide superfamily [IPR037071]", "Amyloidogenic glycoprotein, copper-binding domain superfamily [IPR036669]", "Amyloidogenic glycoprotein, heparin-binding domain superfamily [IPR036454]", "Ankyrin repeat-containing domain superfamily [IPR036770]", "Annexin superfamily [IPR037104]", "Anticodon-binding domain superfamily [IPR036621]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain superfamily [IPR036732]", "ApaG domain superfamily [IPR036767]", "ArfGAP domain superfamily [IPR038508]", "Arginyl tRNA synthetase N-terminal domain superfamily [IPR036695]", "Armadillo-like helical [IPR011989]", "Armadillo-type fold [IPR016024]", "Arp2/3 complex subunit 2/4 [IPR034666]", "Arrestin-like, C-terminal [IPR014752]", "Aspartate decarboxylase-like domain superfamily [IPR009010]", "Aspartate/ornithine carbamoyltransferase superfamily [IPR036901]", "Aspartic peptidase domain superfamily [IPR021109]", "Aspartyl/glutamyl-tRNA amidotransferase subunit B-like [IPR003789]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C-terminal, domain 2 [IPR023168]", "At2g17340, three-helix bundle domain [IPR035073]", "B30.2/SPRY domain superfamily [IPR043136]", "BEACH domain superfamily [IPR036372]", "BRCT domain superfamily [IPR036420]", "BRK domain superfamily [IPR037259]", "BRO1 domain superfamily [IPR038499]", "BSD domain superfamily [IPR035925]", "Bacterial exopeptidase dimerisation domain [IPR036264]", "Band 7/SPFH domain superfamily [IPR036013]", "Barrier-to-autointegration factor, BAF superfamily [IPR036617]", "Bcl-2-like superfamily [IPR036834]", "Beta-Galactosidase/glucuronidase domain superfamily [IPR036156]", "Beta-grasp domain superfamily [IPR012675]", "Beta-hexosaminidase-like, domain 2 [IPR029018]", "Beta-lactamase/transpeptidase-like [IPR012338]", "BolA-like superfamily [IPR036065]", "Branched-chain-amino-acid aminotransferase-like, C-terminal [IPR043132]", "Branched-chain-amino-acid aminotransferase-like, N-terminal [IPR043131]", "Bromo adjacent homology (BAH) domain superfamily [IPR043151]", "Bromodomain-like superfamily [IPR036427]", "C2 domain superfamily [IPR035892]", "CAP Gly-rich domain superfamily [IPR036859]", "CCR4-NOT complex subunit 2/3/5, N-terminal domain superfamily [IPR038635]", "CCR4-NOT subunit 1, TTP binding domain superfamily [IPR038535]", "CDC48 domain 2-like superfamily [IPR029067]", "CDP-alcohol phosphatidyltransferase, transmembrane domain [IPR043130]", "CENP-B, dimerisation domain superfamily [IPR034882]", "CH domain superfamily [IPR036872]", "CRIB domain superfamily [IPR036936]", "CSTF1, dimerization domain superfamily [IPR038184]", "Cadherin-like superfamily [IPR015919]", "Calcyclin-binding protein, N-terminal [IPR037201]", "Calpain large subunit, domain III superfamily [IPR036213]", "Calreticulin/calnexin, P domain superfamily [IPR009033]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily [IPR036480]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily [IPR036897]", "Carbohydrate-binding-like fold [IPR013784]", "Carboxypeptidase-like, regulatory domain superfamily [IPR008969]", "Carnitine o-acyltransferase, N-terminal [IPR042572]", "Casein kinase II subunit beta-like [IPR035991]", "Casein kinase II, regulatory subunit, N-terminal [IPR016149]", "Catenin binding domain superfamily [IPR027397]", "Cdc37, Hsp90-binding domain superfamily [IPR038189]", "Cell division control protein 73, C-terminal domain superfamily [IPR038103]", "Chaperone J-domain superfamily [IPR036869]", "Chitinase insertion domain superfamily [IPR029070]", "Chloramphenicol acetyltransferase-like domain superfamily [IPR023213]", "Chloride channel, core [IPR014743]", "Choline/Carnitine o-acyltransferase, domain 2 [IPR042231]", "Chromo-like domain superfamily [IPR016197]", "Citrate synthase superfamily [IPR036969]", "Citrate synthase-like, large alpha subdomain [IPR016142]", "Citrate synthase-like, small alpha subdomain [IPR016143]", "Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm [IPR010978]", "Class I glutamine amidotransferase-like [IPR029062]", "Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) [IPR045864]", "Class II aldolase/adducin N-terminal domain superfamily [IPR036409]", "Clathrin adaptor, appendage, Ig-like subdomain superfamily [IPR013041]", "Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain [IPR013037]", "Clathrin heavy chain, N-terminal [IPR016025]", "ClpP/crotonase-like domain superfamily [IPR029045]", "Coatomer, gamma subunit, appendage domain superfamily [IPR037067]", "Coatomer/calthrin adaptor appendage, C-terminal subdomain [IPR009028]", "Cobalamin adenosyltransferase-like superfamily [IPR036451]", "Cobalamin-binding domain superfamily [IPR036724]", "Concanavalin A-like lectin/glucanase domain superfamily [IPR013320]", "Creatinase/Aminopeptidase P/Spt16, N-terminal [IPR029149]", "Creatinase/aminopeptidase-like [IPR036005]", "Cullin homology domain superfamily [IPR036317]", "Cullin repeat-like-containing domain superfamily [IPR016159]", "Cupredoxin [IPR008972]", "Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal [IPR016098]", "Cyclic nucleotide-binding-like [IPR018490]", "Cyclic phosphodiesterase [IPR009097]", "Cyclophilin-like domain superfamily [IPR029000]", "Cytidine deaminase-like [IPR016193]", "Cytochrome C oxidase subunit II, transmembrane domain superfamily [IPR036257]", "Cytochrome P450 superfamily [IPR036396]", "Cytochrome b-c1 complex subunit 8 superfamily [IPR036642]", "Cytochrome b-c1 complex subunit 9 superfamily [IPR036656]", "Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400]", "Cytochrome c oxidase subunit IV superfamily [IPR036639]", "Cytochrome c oxidase subunit VIIc superfamily [IPR036636]", "Cytochrome c oxidase, subunit VIIa superfamily [IPR036539]", "Cytochrome c oxidase, subunit Va/VI superfamily [IPR036545]", "Cytochrome c oxidase, subunit Vb superfamily [IPR036972]", "Cytochrome c-like domain superfamily [IPR036909]", "Cytochrome c1, transmembrane anchor, C-terminal [IPR021157]", "Cytochrome cd1-nitrite reductase-like, haem d1 domain superfamily [IPR011048]", "DHS-like NAD/FAD-binding domain superfamily [IPR029035]", "DNA breaking-rejoining enzyme, catalytic core [IPR011010]", "DNA fragmentation factor 45kDa, C-terminal [IPR027296]", "DNA ligase, ATP-dependent, N-terminal domain superfamily [IPR036599]", "DNA mismatch repair protein MutS, N-terminal [IPR016151]", "DNA mismatch repair protein MutS, core domain superfamily [IPR036187]", "DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal [IPR008921]", "DNA polymerase family B, thumb domain [IPR042087]", "DNA polymerase, palm domain superfamily [IPR023211]", "DNA topoisomerase I, DNA binding, N-terminal domain 1 [IPR013034]", "DNA topoisomerase I, DNA binding, N-terminal domain 2 [IPR013030]", "DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily [IPR036202]", "DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type [IPR014711]", "DNA topoisomerase I, catalytic core, alpha/beta subdomain [IPR014727]", "DNA topoisomerase, type IIA, alpha-helical domain superfamily [IPR013757]", "DNA topoisomerase, type IIA, domain A, alpha-beta [IPR013758]", "DNA topoisomerase, type IIA, subunit B, C-terminal [IPR013759]", "DNA topoisomerase, type IIA-like domain superfamily [IPR013760]", "DNA-binding domain superfamily [IPR016177]", "DNA-directed RNA polymerase, N-terminal domain superfamily [IPR037159]", "DNA-directed RNA polymerase, insert domain superfamily [IPR036643]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily [IPR037033]", "DNA/RNA polymerase superfamily [IPR043502]", "DUSP-like superfamily [IPR035927]", "Dbl homology (DH) domain superfamily [IPR035899]", "Death-like domain superfamily [IPR011029]", "Dedicator of cytokinesis, C-terminal, lobe A [IPR043161]", "Dedicator of cytokinesis, C-terminal, lobe C [IPR043162]", "Deoxyhypusine synthase superfamily [IPR036982]", "Diaphanous, GTPase-binding domain superfamily [IPR044933]", "Dihydrofolate reductase-like domain superfamily [IPR024072]", "Dihydropteroate synthase-like [IPR011005]", "Diphthamide synthesis DPH1/DPH2, domain 1 [IPR042263]", "Diphthamide synthesis DPH1/DPH2, domain 3 [IPR042265]", "Disintegrin domain superfamily [IPR036436]", "Dynein heavy chain AAA lid domain superfamily [IPR042219]", "Dynein heavy chain, AAA1 domain, small subdomain [IPR043157]", "Dynein heavy chain, C-terminal domain, barrel region [IPR043160]", "Dynein heavy chain, domain 2, N-terminal [IPR042222]", "Dynein heavy chain, linker, subdomain 3 [IPR042228]", "Dynein light chain superfamily [IPR037177]", "E2 domain superfamily [IPR036176]", "E3-binding domain superfamily [IPR036625]", "EB1, C-terminal domain superfamily [IPR036133]", "EF-G domain III/V-like [IPR035647]", "EF-hand domain pair [IPR011992]", "ENTH/VHS [IPR008942]", "ERO1-like superfamily [IPR037192]", "ERV/ALR sulfhydryl oxidase domain superfamily [IPR036774]", "ESCRT assembly domain [IPR037202]", "EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2 [IPR042044]", "Elongation factor EF1B gamma, C-terminal domain superfamily [IPR036433]", "Elongation factor Ts, dimerisation domain superfamily [IPR036402]", "Endonuclease/exonuclease/phosphatase superfamily [IPR036691]", "Endoplasmic reticulum resident protein 29, C-terminal domain superfamily [IPR036356]", "Enhancer of mRNA-decapping protein 4, conserved C-terminal domain [IPR044938]", "Enhancer of rudimentary superfamily [IPR035912]", "Enolase-like, C-terminal domain superfamily [IPR036849]", "Enolase-like, N-terminal [IPR029017]", "Enoyl-CoA hydratase, C-terminal [IPR014748]", "Eukaryotic translation initiation factor 3-like domain superfamily [IPR023194]", "Exocyst complex component EXOC3/Sec6, C-terminal domain [IPR042532]", "Exoribonuclease, PH domain 2 superfamily [IPR036345]", "F-actin capping protein, alpha subunit, domain 1 [IPR042489]", "F-actin-capping protein subunit alpha/beta [IPR037282]", "F-actin-capping protein subunit alpha/beta, domain 2 [IPR042276]", "F-actin-capping protein subunit beta, N-terminal domain [IPR043175]", "F-box-like domain superfamily [IPR036047]", "F1F0 ATP synthase OSCP/delta subunit, N-terminal domain superfamily [IPR026015]", "FAD-binding, type PCMH, subdomain 1 [IPR016167]", "FAD-binding, type PCMH, subdomain 2 [IPR016169]", "FAD-binding, type PCMH-like superfamily [IPR036318]", "FAD-linked oxidase-like, C-terminal [IPR016164]", "FAD/NAD(P)-binding domain superfamily [IPR036188]", "FAD/NAD-linked reductase, dimerisation domain superfamily [IPR016156]", "FCS-type zinc finger superfamily [IPR038603]", "FERM superfamily, second domain [IPR035963]", "FERM/acyl-CoA-binding protein superfamily [IPR014352]", "FF domain superfamily [IPR036517]", "FIP-RBD, C-terminal domain superfamily [IPR037245]", "FKBP12-rapamycin binding domain superfamily [IPR036738]", "FTO, C-terminal domain superfamily [IPR038413]", "Ferredoxin-NADP reductase (FNR), nucleotide-binding domain [IPR039261]", "Ferritin-like superfamily [IPR009078]", "Fibronectin type II domain superfamily [IPR036943]", "Fibronectin type III superfamily [IPR036116]", "Flavoprotein-like superfamily [IPR029039]", "Formin, FH2 domain superfamily [IPR042201]", "Formyl transferase, N-terminal domain superfamily [IPR036477]", "Fumarase/histidase, N-terminal [IPR024083]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily [IPR037099]", "Fumarylacetoacetase, N-terminal domain superfamily [IPR036462]", "Fumarylacetoacetase-like, C-terminal domain superfamily [IPR036663]", "G protein alpha subunit, helical insertion [IPR011025]", "GAD-like domain superfamily [IPR004115]", "GAR domain superfamily [IPR036534]", "GAT domain superfamily [IPR038425]", "GHMP kinase, C-terminal domain superfamily [IPR036554]", "GINS, helical bundle-like domain superfamily [IPR036224]", "GLE1-like superfamily [IPR038506]", "GM2-AP, lipid-recognition domain superfamily [IPR036846]", "GMP phosphodiesterase, delta subunit superfamily [IPR037036]", "GOLD domain superfamily [IPR036598]", "GSKIP domain superfamily [IPR023231]", "GTF2I-like repeat superfamily [IPR036647]", "GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 [IPR027266]", "GTP-binding protein, orthogonal bundle domain superfamily [IPR023179]", "GTP1/OBG domain superfamily [IPR036726]", "GYF-like domain superfamily [IPR035445]", "Galactose mutarotase-like domain superfamily [IPR011013]", "Galactose oxidase/kelch, beta-propeller [IPR011043]", "Galactose-binding-like domain superfamily [IPR008979]", "Gamma-glutamyl cyclotransferase-like superfamily [IPR036568]", "Gamma-tubulin complex component, C-terminal domain superfamily [IPR042241]", "Gelsolin-like domain superfamily [IPR036180]", "Glutamine synthetase/guanido kinase, catalytic domain [IPR014746]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1 [IPR042558]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2 [IPR042559]", "Glutathione S-transferase, C-terminal domain superfamily [IPR036282]", "Glutathione synthase, C-terminal, eukaryotic [IPR014709]", "Glutathione synthase, N-terminal, eukaryotic [IPR014049]", "Glutathione synthase, alpha-helical [IPR014042]", "Glutathione synthase, substrate-binding domain superfamily [IPR037013]", "Glycine cleavage T-protein/YgfZ, C-terminal [IPR029043]", "Glycoside hydrolase superfamily [IPR017853]", "Glycosyl hydrolase family 63, N-terminal domain superfamily [IPR038518]", "Glycosyl hydrolase, all-beta [IPR013780]", "Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [IPR029068]", "GroEL-like apical domain superfamily [IPR027409]", "GroEL-like equatorial domain superfamily [IPR027413]", "GroES chaperonin superfamily [IPR037124]", "GroES-like superfamily [IPR011032]", "Growth arrest and DNA damage-inducible proteins-interacting protein 1 domain superfamily [IPR043035]", "Growth factor receptor cysteine-rich domain superfamily [IPR009030]", "GrpE nucleotide exchange factor, coiled-coil [IPR013805]", "GrpE nucleotide exchange factor, head [IPR009012]", "Guanylate-binding protein, C-terminal domain superfamily [IPR036543]", "H/ACA RNP complex subunit Gar1/Naf1, Cbf5-binding domain [IPR038664]", "HAD superfamily [IPR023214]", "HAD-like superfamily [IPR036412]", "HAD-superfamily hydrolase, subfamily IA, REG-2-like, capping domain superfamily [IPR044924]", "HBS1-like protein, N-terminal domain superfamily [IPR037189]", "HECT, E3 ligase catalytic domain [IPR035983]", "HIT-like superfamily [IPR036265]", "HIV integrase-binding domain superfamily [IPR036218]", "HR1 repeat superfamily [IPR036274]", "HRDC domain superfamily [IPR044876]", "HRDC-like superfamily [IPR010997]", "HSP20-like chaperone [IPR008978]", "HSP40/DnaJ peptide-binding [IPR008971]", "HSP90, C-terminal domain [IPR037196]", "Haem oxygenase-like, multi-helical [IPR016084]", "Heat shock protein 70kD, C-terminal domain superfamily [IPR029048]", "Heat shock protein 70kD, peptide-binding domain superfamily [IPR029047]", "Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410]", "Hemimethylated DNA-binding domain superfamily [IPR036623]", "High mobility group box domain superfamily [IPR036910]", "Histidine kinase/HSP90-like ATPase superfamily [IPR036890]", "Histidine phosphatase superfamily [IPR029033]", "Histone acetyl transferase 1, N-terminal domain superfamily [IPR037113]", "Histone acetyltransferase HAT1, C-terminal [IPR013523]", "Histone deacetylase domain superfamily [IPR037138]", "Histone-fold [IPR009072]", "Homeobox-like domain superfamily [IPR009057]", "Homocysteine-binding domain superfamily [IPR036589]", "HotDog domain superfamily [IPR029069]", "Hypoxia-inducible factor 1-alpha inhibitor, domain II [IPR027452]", "I/LWEQ domain superfamily [IPR035964]", "ISWI, HAND domain superfamily [IPR036306]", "Immunoglobulin E-set [IPR014756]", "Immunoglobulin-like domain superfamily [IPR036179]", "Immunoglobulin-like fold [IPR013783]", "Importin-alpha, importin-beta-binding domain superfamily [IPR036975]", "Initiation factor 2B-like, C-terminal [IPR042529]", "Inorganic polyphosphate/ATP-NAD kinase, N-terminal [IPR017438]", "Inorganic pyrophosphatase superfamily [IPR036649]", "Inosine triphosphate pyrophosphatase-like [IPR029001]", "Integrase-like, N-terminal [IPR017856]", "Integrin beta tail domain superfamily [IPR036349]", "Integrin domain superfamily [IPR032695]", "Invasin/intimin cell-adhesion fragments [IPR008964]", "Isochorismatase-like superfamily [IPR036380]", "Isopenicillin N synthase-like superfamily [IPR027443]", "Isoprenoid synthase domain superfamily [IPR008949]", "K Homology domain, type 1 superfamily [IPR036612]", "K homology domain superfamily, prokaryotic type [IPR009019]", "K homology domain-like, alpha/beta [IPR015946]", "KA1 domain/Ssp2, C-terminal [IPR028375]", "Kelch-type beta propeller [IPR015915]", "Kinesin motor domain superfamily [IPR036961]", "Kinesin-like protein Kif23, Arf6-interacting domain superfamily [IPR038105]", "Kringle-like fold [IPR013806]", "Ku, C-terminal domain superfamily [IPR036494]", "Ku70, bridge and pillars domain superfamily [IPR027388]", "L-Aspartase-like [IPR008948]", "L21-like superfamily [IPR036164]", "L27 domain superfamily [IPR036892]", "L28p-like [IPR034704]", "LAP1C-like, C-terminal domain superfamily [IPR038599]", "LDL receptor-like superfamily [IPR036055]", "LEM/LEM-like domain superfamily [IPR011015]", "LIS1, N-terminal [IPR037190]", "LSM domain superfamily [IPR010920]", "Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal [IPR015955]", "Lamin tail domain superfamily [IPR036415]", "Leucine-rich repeat domain superfamily [IPR032675]", "LexA/Signal peptidase-like superfamily [IPR036286]", "Longin-like domain superfamily [IPR011012]", "MAGE homology domain, winged helix WH1 motif [IPR041898]", "MAGE homology domain, winged helix WH2 motif [IPR041899]", "MAN1, winged-helix domain [IPR041885]", "MFS transporter superfamily [IPR036259]", "MHC class I-like antigen recognition-like superfamily [IPR037055]", "MHC classes I/II-like antigen recognition protein [IPR011162]", "MIT domain superfamily [IPR036181]", "MOB kinase activator superfamily [IPR036703]", "MRG, C-terminal domain superfamily [IPR038217]", "MRP-L47 superfamily, mitochondrial [IPR038340]", "Macro domain-like [IPR043472]", "Malic enzyme, N-terminal domain superfamily [IPR037062]", "Malonyl-CoA ACP transacylase, ACP-binding [IPR016036]", "Manganese/iron superoxide dismutase, C-terminal domain superfamily [IPR036314]", "Manganese/iron superoxide dismutase, N-terminal domain superfamily [IPR036324]", "Mannose-6-phosphate receptor binding domain superfamily [IPR009011]", "Membrane associated eicosanoid/glutathione metabolism-like domain superfamily [IPR023352]", "Metal-dependent hydrolase [IPR032466]", "Metal-dependent hydrolase, composite domain superfamily [IPR011059]", "Metallo-dependent phosphatase-like [IPR029052]", "Metalloenzyme, LuxS/M16 peptidase-like [IPR011249]", "Metallopeptidase, catalytic domain superfamily [IPR024079]", "Methionine synthase domain [IPR036594]", "Methionyl-tRNA synthetase, Zn-domain [IPR029038]", "Methylglyoxal synthase-like domain superfamily [IPR036914]", "Methylthioribose-1-phosphate isomerase, N-terminal [IPR027363]", "Methylthiotransferase, N-terminal domain superfamily [IPR038135]", "Mib/herc2 domain superfamily [IPR037252]", "MitoNEET, CDGSH iron-sulfur domain [IPR042216]", "Mitochondrial carrier domain superfamily [IPR023395]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamily [IPR037169]", "Mitochondrial glycoprotein superfamily [IPR036561]", "Mitochondrial outer membrane translocase complex, Tom20 domain superfamily [IPR023392]", "MoaB/Mog-like domain superfamily [IPR036425]", "Moesin tail domain superfamily [IPR008954]", "Mre11, capping domain [IPR038487]", "Mss4-like superfamily [IPR011057]", "Mss4/translationally controlled tumour-associated TCTP [IPR011323]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily [IPR042179]", "MutS, connector domain superfamily [IPR036678]", "Myosin S1 fragment, N-terminal [IPR008989]", "NAC A/B domain superfamily [IPR038187]", "NAD kinase/diacylglycerol kinase-like domain superfamily [IPR016064]", "NAD(P)-binding domain superfamily [IPR036291]", "NADH-quinone oxidoreductase subunit E, N-terminal [IPR041921]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily [IPR037225]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily [IPR037207]", "NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily [IPR037232]", "NADP-dependent oxidoreductase domain superfamily [IPR036812]", "NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily [IPR023173]", "NAP-like superfamily [IPR037231]", "NET domain superfamily [IPR038336]", "NO signalling/Golgi transport ligand-binding domain superfamily [IPR024096]", "NOB1 zinc finger-like superfamily [IPR036283]", "NSFL1 cofactor p47, SEP domain superfamily [IPR036241]", "NTF2-like domain superfamily [IPR032710]", "NUDIX hydrolase-like domain superfamily [IPR015797]", "NVL2, N-terminal domain superfamily [IPR038100]", "NagB/RpiA transferase-like [IPR037171]", "Neurolysin/Thimet oligopeptidase, N-terminal [IPR024080]", "Neurolysin/Thimet oligopeptidase, domain 2 [IPR024077]", "Nicotinate phosphoribosyltransferase-like, C-terminal [IPR036068]", "Nitrogen regulatory PII-like, alpha/beta [IPR011322]", "Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal [IPR015867]", "Nitrous oxide reductase, N-terminal [IPR011045]", "Nop domain superfamily [IPR036070]", "Nop, C-terminal domain [IPR042239]", "Nucleic acid-binding, OB-fold [IPR012340]", "Nucleophile aminohydrolases, N-terminal [IPR029055]", "Nucleoplasmin core domain superfamily [IPR036824]", "Nucleoporin, Nup155-like, C-terminal, subdomain 1 [IPR042533]", "Nucleoporin, Nup155-like, C-terminal, subdomain 2 [IPR042537]", "Nucleoporin, Nup155-like, C-terminal, subdomain 3 [IPR042538]", "Nucleoside diphosphate kinase-like domain superfamily [IPR036850]", "Nucleoside phosphorylase superfamily [IPR035994]", "Nucleotide-binding alpha-beta plait domain superfamily [IPR012677]", "Nucleotide-diphospho-sugar transferases [IPR029044]", "Nucleotidyltransferase superfamily [IPR043519]", "Nucleotidyltransferase, class I-like, C-terminal [IPR011068]", "NusG, N-terminal domain superfamily [IPR036735]", "Oxygen-dependent coproporphyrinogen III oxidase superfamily [IPR036406]", "Oxysterol-binding protein superfamily [IPR037239]", "P-loop containing nucleoside triphosphate hydrolase [IPR027417]", "P-type ATPase, A domain superfamily [IPR008250]", "P-type ATPase, cytoplasmic domain N [IPR023299]", "P-type ATPase, transmembrane domain superfamily [IPR023298]", "P-type trefoil domain superfamily [IPR044913]", "PABC (PABP) domain [IPR036053]", "PADR1 domain superfamily [IPR038650]", "PBDC1-like domain superfamily [IPR023139]", "PDCD5-like superfamily [IPR036883]", "PDZ superfamily [IPR036034]", "PEBP-like superfamily [IPR036610]", "PFU domain superfamily [IPR038122]", "PH-like domain superfamily [IPR011993]", "PIN-like domain superfamily [IPR029060]", "PITH domain superfamily [IPR037047]", "PNPase/RNase PH domain superfamily [IPR027408]", "POLO box domain superfamily [IPR036947]", "PPM-type phosphatase domain superfamily [IPR036457]", "PRP4-like superfamily [IPR036285]", "PTPA superfamily [IPR037218]", "PUA domain superfamily [IPR036974]", "PUA-like superfamily [IPR015947]", "PWI domain superfamily [IPR036483]", "PX domain superfamily [IPR036871]", "Paired amphipathic helix superfamily [IPR036600]", "Pancreatic trypsin inhibitor Kunitz domain superfamily [IPR036880]", "PapD-like superfamily [IPR008962]", "Papain-like cysteine peptidase superfamily [IPR038765]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily [IPR036959]", "Peptidase C65, otubain, subdomain 2 [IPR042467]", "Peptidase C65, otubain, subdomain 1 [IPR042468]", "Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily [IPR038502]", "Peptidase M13, domain 2 [IPR042089]", "Peptidase M4/M1, CTD superfamily [IPR027268]", "Peptidase M41-like [IPR037219]", "Peptidase M60, enhancin-like domain 3 [IPR042279]", "Peptidase S1, PA clan [IPR009003]", "Peptidase S59, nucleoporin superfamily [IPR036903]", "Peptidase S8/S53 domain superfamily [IPR036852]", "Peptidyl-tRNA hydrolase II domain superfamily [IPR023476]", "Phenylalanyl-tRNA synthetase-like, B3/B4 [IPR020825]", "Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily [IPR036940]", "Phosphofructokinase superfamily [IPR035966]", "Phosphoglucose isomerase, C-terminal [IPR023096]", "Phosphoglycerate kinase superfamily [IPR036043]", "Phosphoglycerate kinase, N-terminal [IPR015824]", "Phospholipase B-like, domain 1 [IPR043040]", "Phospholipase B-like, domain 2 [IPR043041]", "Phospholipase B-like, domain 3 [IPR043042]", "Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily [IPR036604]", "Phosphoribosylglycinamide synthetase, C-domain superfamily [IPR037123]", "Phosphoribosyltransferase-like [IPR029057]", "Phosphorylated adapter RNA export protein, RNA-binding domain superfamily [IPR038092]", "Phosphotyrosine protein phosphatase I superfamily [IPR036196]", "Phosphotyrosyl phosphatase activator, C-terminal lid domain [IPR043170]", "Plakin repeat superfamily [IPR035915]", "Poly(ADP-ribose) polymerase, regulatory domain superfamily [IPR036616]", "Polyketide synthase, dehydratase domain superfamily [IPR042104]", "Polymerase/histidinol phosphatase-like [IPR016195]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily [IPR036456]", "Porin domain superfamily [IPR023614]", "Pre-ATP-grasp domain superfamily [IPR016185]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily [IPR042516]", "Prefoldin [IPR009053]", "Profilin superfamily [IPR036140]", "Prolyl-tRNA synthetase, class II [IPR017449]", "Proteasomal ubiquitin receptor Rpn13/ADRM1, Pru domain superfamily [IPR038633]", "Proteasome activator PA28, C-terminal domain superfamily [IPR036997]", "Proteasome activator PA28, N-terminal domain superfamily [IPR036996]", "Proteasome activator superfamily [IPR036252]", "Proteasome assembly chaperone 2 superfamily [IPR038389]", "Protein arginine methyltransferase NDUFAF7 superfamily [IPR038375]", "Protein kinase-like domain superfamily [IPR011009]", "Protein-tyrosine phosphatase-like [IPR029021]", "Prp8 RNase domain IV, fingers region [IPR043173]", "Prp8 RNase domain IV, palm region [IPR043172]", "Pseudouridine synthase I, TruA, C-terminal [IPR020095]", "Pseudouridine synthase TruA/RsuA/RluB/E/F, N-terminal [IPR020094]", "Pseudouridine synthase, TruD, catalytic domain [IPR042214]", "Pseudouridine synthase, catalytic domain superfamily [IPR020103]", "PurM-like, C-terminal domain superfamily [IPR036676]", "PurM-like, N-terminal domain superfamily [IPR036921]", "Putative DNA-binding domain superfamily [IPR009061]", "Pyridoxal phosphate-dependent transferase [IPR015424]", "Pyridoxal phosphate-dependent transferase, major domain [IPR015421]", "Pyridoxal phosphate-dependent transferase, small domain [IPR015422]", "Pyruvate kinase, C-terminal domain superfamily [IPR036918]", "Pyruvate kinase, insert domain superfamily [IPR015806]", "Pyruvate kinase-like domain superfamily [IPR040442]", "Pyruvate kinase-like, insert domain superfamily [IPR011037]", "Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily [IPR015813]", "Quinoprotein alcohol dehydrogenase-like superfamily [IPR011047]", "Quinoprotein amine dehydrogenase, beta chain-like [IPR011044]", "R3H domain superfamily [IPR036867]", "RAP domain superfamily [IPR036744]", "RGS domain superfamily [IPR036305]", "RNA 3'-terminal phosphate cyclase domain superfamily [IPR037136]", "RNA 3'-terminal phosphate cyclase, insert domain superfamily [IPR036553]", "RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta [IPR013792]", "RNA polymerase Rpb1, clamp domain superfamily [IPR044893]", "RNA polymerase Rpb1, domain 3 superfamily [IPR042102]", "RNA polymerase Rpb1, domain 7 superfamily [IPR038593]", "RNA polymerase Rpb1, funnel domain superfamily [IPR038120]", "RNA polymerase Rpb2, OB-fold [IPR014724]", "RNA polymerase Rpb2, domain 2 superfamily [IPR037034]", "RNA polymerase Rpb5, N-terminal domain superfamily [IPR036710]", "RNA polymerase Rpb7-like, N-terminal domain superfamily [IPR036898]", "RNA polymerase, RBP11-like subunit [IPR036603]", "RNA-binding S4 domain superfamily [IPR036986]", "RNA-binding domain superfamily [IPR035979]", "RPB5-like RNA polymerase subunit superfamily [IPR035913]", "RPN13, DEUBAD domain superfamily [IPR038108]", "RRF superfamily [IPR036191]", "RUN domain superfamily [IPR037213]", "Rab geranylgeranyltransferase, alpha subunit, insert-domain superfamily [IPR036254]", "Rab-GTPase-TBC domain superfamily [IPR035969]", "Radical SAM, alpha/beta horseshoe [IPR023404]", "Ran-GTPase activating protein 1, C-terminal domain superfamily [IPR036720]", "Rap/Ran-GAP superfamily [IPR035974]", "Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II [IPR009091]", "Regulatory factor, effector binding domain superfamily [IPR011256]", "Rho GDP-dissociation inhibitor domain superfamily [IPR024792]", "Rho GTPase activation protein [IPR008936]", "Rhodanese-like domain superfamily [IPR036873]", "Rhomboid-like superfamily [IPR035952]", "Riboflavin synthase-like beta-barrel [IPR017938]", "Ribokinase-like [IPR029056]", "Ribonuclease H superfamily [IPR036397]", "Ribonuclease H-like superfamily [IPR012337]", "Ribonuclease H1, N-terminal domain superfamily [IPR037056]", "Ribonuclease HII, helix-loop-helix cap domain superfamily [IPR023160]", "Ribonuclease III, endonuclease domain superfamily [IPR036389]", "Ribonuclease T2-like superfamily [IPR036430]", "Ribonuclease Z/Hydroxyacylglutathione hydrolase-like [IPR036866]", "Ribonucleotide reductase R1 subunit, N-terminal [IPR008926]", "Ribonucleotide reductase-like [IPR012348]", "Ribosomal L15/L27a, N-terminal [IPR027386]", "Ribosomal L18e/L15P superfamily [IPR036227]", "Ribosomal RNA-processing protein 8, N-terminal domain [IPR042036]", "Ribosomal protein L1, 3-layer alpha/beta-sandwich [IPR016095]", "Ribosomal protein L1-like [IPR023674]", "Ribosomal protein L10-like domain superfamily [IPR043141]", "Ribosomal protein L10e/L16 superfamily [IPR036920]", "Ribosomal protein L11, C-terminal domain superfamily [IPR036769]", "Ribosomal protein L11/L12, N-terminal domain superfamily [IPR036796]", "Ribosomal protein L13 superfamily [IPR036899]", "Ribosomal protein L14 superfamily [IPR036853]", "Ribosomal protein L15e core domain superfamily [IPR024794]", "Ribosomal protein L19 superfamily [IPR038657]", "Ribosomal protein L19/L19e superfamily [IPR035970]", "Ribosomal protein L19/L19e, domain 1 [IPR015972]", "Ribosomal protein L2, domain 2 [IPR014722]", "Ribosomal protein L2, domain 3 [IPR014726]", "Ribosomal protein L21 superfamily [IPR036948]", "Ribosomal protein L22/L17 superfamily [IPR036394]", "Ribosomal protein L22e superfamily [IPR038526]", "Ribosomal protein L23/L15e core domain superfamily [IPR012678]", "Ribosomal protein L24e/L24 superfamily [IPR038630]", "Ribosomal protein L25/Gln-tRNA synthetase, N-terminal [IPR020056]", "Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily [IPR011035]", "Ribosomal protein L27e superfamily [IPR038655]", "Ribosomal protein L28/L24 superfamily [IPR037147]", "Ribosomal protein L29/L35 superfamily [IPR036049]", "Ribosomal protein L3, domain 3, archaeal type superfamily [IPR044892]", "Ribosomal protein L30, ferredoxin-like fold domain superfamily [IPR036919]", "Ribosomal protein L31e domain superfamily [IPR023621]", "Ribosomal protein L32e superfamily [IPR036351]", "Ribosomal protein L35A superfamily [IPR038661]", "Ribosomal protein L36e domain superfamily [IPR038097]", "Ribosomal protein L37ae/L37e [IPR011331]", "Ribosomal protein L38e superfamily [IPR038464]", "Ribosomal protein L4 domain superfamily [IPR023574]", "Ribosomal protein L5 domain superfamily [IPR022803]", "Ribosomal protein L6, alpha-beta domain superfamily [IPR036789]", "Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like [IPR014719]", "Ribosomal protein L7/L12, oligomerisation domain superfamily [IPR036235]", "Ribosomal protein L9, N-terminal domain superfamily [IPR036935]", "Ribosomal protein L9/RNase H1, N-terminal [IPR009027]", "Ribosomal protein P1/P2, N-terminal domain [IPR038716]", "Ribosomal protein S10 domain superfamily [IPR036838]", "Ribosomal protein S11 superfamily [IPR036967]", "Ribosomal protein S13-like, H2TH [IPR010979]", "Ribosomal protein S17e-like superfamily [IPR036401]", "Ribosomal protein S19/S15, superfamily [IPR023575]", "Ribosomal protein S2, flavodoxin-like domain superfamily [IPR023591]", "Ribosomal protein S21e superfamily [IPR038579]", "Ribosomal protein S3, C-terminal domain superfamily [IPR036419]", "Ribosomal protein S4e, central domain superfamily [IPR038237]", "Ribosomal protein S5 domain 2-type fold [IPR020568]", "Ribosomal protein S5 domain 2-type fold, subgroup [IPR014721]", "Ribosomal protein S7 domain superfamily [IPR036823]", "Ribosomal protein S8 superfamily [IPR035987]", "Ribosomal protein S8e subdomain, eukaryotes [IPR042563]", "Ribosome maturation protein SBDS, N-terminal domain superfamily [IPR036786]", "Ribosome maturation protein Sdo1/SBDS, central domain superfamily [IPR037188]", "Ribosome-associated complex head domain superfamily [IPR042569]", "Ribulose-phosphate binding barrel [IPR011060]", "Ricin B-like lectins [IPR035992]", "RmlC-like cupin domain superfamily [IPR011051]", "RmlC-like jelly roll fold [IPR014710]", "Rossmann-like alpha/beta/alpha sandwich fold [IPR014729]", "Rudiment single hybrid motif [IPR011054]", "RuvA domain 2-like [IPR010994]", "RuvBL1/2, DNA/RNA binding domain [IPR042487]", "S-adenosyl-L-methionine-dependent methyltransferase [IPR029063]", "S-adenosylmethionine synthetase superfamily [IPR022636]", "S15/NS1, RNA-binding [IPR009068]", "SAP domain superfamily [IPR036361]", "SCP2 sterol-binding domain superfamily [IPR036527]", "SGNH hydrolase superfamily [IPR036514]", "SH2 domain superfamily [IPR036860]", "SH3-like domain superfamily [IPR036028]", "SKP1-like, dimerisation domain superfamily [IPR036296]", "SKP1/BTB/POZ domain superfamily [IPR011333]", "SMAD/FHA domain superfamily [IPR008984]", "SMCs flexible hinge superfamily [IPR036277]", "SNARE [IPR010989]", "SNF2-like, N-terminal domain superfamily [IPR038718]", "SNase-like, OB-fold superfamily [IPR035437]", "SOS response associated peptidase-like [IPR036590]", "SPOC-like, C-terminal domain superfamily [IPR016194]", "SRA-YDG superfamily [IPR036987]", "SRCR-like domain superfamily [IPR036772]", "SRP/SRP receptor, N-terminal [IPR036225]", "SRP68, N-terminal domain superfamily [IPR038253]", "SSRP1 domain superfamily [IPR038167]", "START-like domain superfamily [IPR023393]", "STAT transcription factor, DNA-binding, N-terminal [IPR012345]", "STAT transcription factor, N-terminal domain superfamily [IPR036535]", "STAT transcription factor, coiled coil [IPR015988]", "SUI1 domain superfamily [IPR036877]", "SWAP/Surp superfamily [IPR035967]", "SWIB/MDM2 domain superfamily [IPR036885]", "Scavenger mRNA decapping enzyme, N-terminal [IPR011145]", "Schlafen, AlbA_2 domain superfamily [IPR038461]", "ScpA-like, C-terminal [IPR023093]", "Sec1-like superfamily [IPR036045]", "Sec1-like, domain 1 [IPR043154]", "Sec1-like, domain 2 [IPR027482]", "Sec1-like, domain 3a [IPR043127]", "Sec23/Sec24 helical domain superfamily [IPR036175]", "Sec7 domain superfamily [IPR035999]", "Sec7, C-terminal domain superfamily [IPR023394]", "SecY domain superfamily [IPR023201]", "Secretoglobin superfamily [IPR035960]", "Serine carboxypeptidase S28, SKS domain [IPR042269]", "Serine-tRNA synthetase, type1, N-terminal domain superfamily [IPR042103]", "Serpin superfamily [IPR036186]", "Serpin superfamily, domain 1 [IPR042178]", "Serpin superfamily, domain 2 [IPR042185]", "Sialidase superfamily [IPR036278]", "Signal recognition particle SRP54, N-terminal domain superfamily [IPR042101]", "Signal recognition particle, SRP54 subunit, M-domain superfamily [IPR036891]", "Signal recognition particle, SRP9/SRP14 subunit [IPR009018]", "Signal recognition particle, subunit SRP19-like superfamily [IPR036521]", "Sin3 associated polypeptide p18 superfamily [IPR042534]", "Single hybrid motif [IPR011053]", "Sirtuin, catalytic core small domain superfamily [IPR026591]", "Six-bladed beta-propeller, TolB-like [IPR011042]", "Six-hairpin glycosidase superfamily [IPR008928]", "Six-hairpin glycosidase-like superfamily [IPR012341]", "Smac/DIABLO-like superfamily [IPR009062]", "Sodium/potassium-transporting ATPase subunit beta superfamily [IPR038702]", "Sodium:dicarboxylate symporter superfamily [IPR036458]", "Sodium:neurotransmitter symporter superfamily [IPR037272]", "Soluble quinoprotein glucose/sorbosone dehydrogenase [IPR011041]", "Spermadhesin, CUB domain superfamily [IPR035914]", "Spermidine synthase, tetramerisation domain superfamily [IPR037163]", "Spt6, Death-like domain [IPR042066]", "Stathmin superfamily [IPR036002]", "Sterile alpha motif/pointed domain superfamily [IPR013761]", "Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily [IPR027477]", "Succinyl-CoA synthetase-like [IPR016102]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain superfamily [IPR042568]", "Sushi/SCR/CCP superfamily [IPR035976]", "TAP42/TAP46-like superfamily [IPR038511]", "TBP domain superfamily [IPR012295]", "TCP-1-like chaperonin intermediate domain superfamily [IPR027410]", "TEL2, C-terminal domain superfamily [IPR038528]", "TFIIIC, subcomplex tauA subunit Sfc1, triple barrel domain superfamily [IPR042536]", "TFIIS/LEDGF domain superfamily [IPR035441]", "TGS-like [IPR012676]", "TGS-like domain superfamily [IPR023192]", "TRAF-like [IPR008974]", "TROVE domain superfamily [IPR037214]", "Talin, central domain superfamily [IPR036476]", "Tautomerase/MIF superfamily [IPR014347]", "Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid [IPR008930]", "Tetraspanin, EC2 domain superfamily [IPR008952]", "Tetratricopeptide-like helical domain superfamily [IPR011990]", "Tex-like domain superfamily [IPR023323]", "Tex-like protein, HTH domain superfamily [IPR023319]", "Thiamin diphosphate-binding fold [IPR029061]", "Thiolase-like [IPR016039]", "Thioredoxin-like superfamily [IPR036249]", "Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily [IPR018163]", "Thymidylate synthase/dCMP hydroxymethylase superfamily [IPR036926]", "Tim10-like domain superfamily [IPR035427]", "Transcription elongation factor S-II, central domain superfamily [IPR036575]", "Transcription factor EnY2 superfamily [IPR038212]", "Transcription termination and cleavage factor, C-terminal domain superfamily [IPR038192]", "Transcriptional regulator TACO1-like, domain 3 [IPR026564]", "Transferrin receptor-like, dimerisation domain superfamily [IPR036757]", "Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II [IPR009014]", "Translation Initiation factor eIF- 4e-like [IPR023398]", "Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal [IPR009001]", "Translation elongation factor EF1B/ribosomal protein S6 [IPR014717]", "Translation elongation factor eEF-1beta-like superfamily [IPR036219]", "Translation initiation factor 2, alpha subunit, C-terminal [IPR024055]", "Translation initiation factor 2, alpha subunit, middle domain superfamily [IPR024054]", "Translation initiation factor 3, subunit 12, N-terminal, eukaryotic [IPR016020]", "Translation initiation factor IF-2, domain 3 superfamily [IPR036925]", "Translation initiation factor IF2/IF5, N-terminal [IPR016189]", "Translation initiation factor IF2/IF5, zinc-binding [IPR016190]", "Translation initiation factor eIF-2B subunit alpha, N-terminal [IPR042528]", "Translation protein SH3-like domain superfamily [IPR008991]", "Translation protein, beta-barrel domain superfamily [IPR009000]", "Translin superfamily [IPR036081]", "Translin, C-terminal [IPR016069]", "Translin, N-terminal [IPR016068]", "Trimeric LpxA-like superfamily [IPR011004]", "Triosephosphate isomerase superfamily [IPR035990]", "Tubulin binding cofactor A superfamily [IPR036126]", "Tubulin, C-terminal [IPR023123]", "Tubulin/FtsZ, C-terminal [IPR008280]", "Tubulin/FtsZ, GTPase domain superfamily [IPR036525]", "Tubulin/FtsZ-like, C-terminal domain [IPR037103]", "UBA-like superfamily [IPR009060]", "UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily [IPR036220]", "UROD/MetE-like superfamily [IPR038071]", "Ubiquitin activating enzyme, alpha domain superfamily [IPR023318]", "Ubiquitin-activating enzyme E1, C-terminal domain superfamily [IPR038252]", "Ubiquitin-activating enzyme E1, FCCH domain superfamily [IPR042302]", "Ubiquitin-activating enzyme E1, SCCH domain [IPR042063]", "Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 [IPR042449]", "Ubiquitin-activating enzyme [IPR035985]", "Ubiquitin-conjugating enzyme/RWD-like [IPR016135]", "Ubiquitin-like domain superfamily [IPR029071]", "Ufd1-like, Nn domain [IPR042299]", "Uracil-DNA glycosylase-like domain superfamily [IPR036895]", "Ureohydrolase domain superfamily [IPR023696]", "V-type ATP synthase c/d subunit, domain 3 superfamily [IPR044911]", "V-type ATP synthase subunit c/d subunit superfamily [IPR036079]", "V-type ATPase subunit C/d [IPR035067]", "V-type ATPase subunit E, C-terminal domain superfamily [IPR038495]", "VASP tetramerisation domain superfamily [IPR038023]", "VPS9 domain superfamily [IPR037191]", "Vacuolar ATP synthase subunit C superfamily [IPR036132]", "Vacuolar protein sorting-associated protein 33, domain 3b [IPR043155]", "Vacuolar protein sorting-associated protein 35, C-terminal [IPR042491]", "Vacuolar protein sorting-associated protein IST1-like [IPR042277]", "Valyl-tRNA synthetase, tRNA-binding arm superfamily [IPR037118]", "Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain [IPR009008]", "Vanillyl-alcohol oxidase, C-terminal subdomain 2 [IPR016171]", "Vitamin B12-dependent methionine synthase, activation domain superfamily [IPR037010]", "Vps16, C-terminal domain superfamily [IPR038132]", "Vps53, C-terminal domain superfamily [IPR038260]", "WD40-repeat-containing domain superfamily [IPR036322]", "WD40/YVTN repeat-like-containing domain superfamily [IPR015943]", "WGR domain superfamily [IPR036930]", "WW domain superfamily [IPR036020]", "WWE domain superfamily [IPR037197]", "Winged helix DNA-binding domain superfamily [IPR036390]", "Winged helix-like DNA-binding domain superfamily [IPR036388]", "XPC-binding domain superfamily [IPR036353]", "YEATS superfamily [IPR038704]", "YebC-like [IPR029072]", "YjeF N-terminal domain superfamily [IPR036652]", "YqgF/RNase H-like domain superfamily [IPR037027]", "Zinc finger C2H2 superfamily [IPR036236]", "Zinc finger, CCCH-type superfamily [IPR036855]", "Zinc finger, CCHC-type superfamily [IPR036875]", "Zinc finger, FYVE/PHD-type [IPR011011]", "Zinc finger, PARP-type superfamily [IPR036957]", "Zinc finger, RING/FYVE/PHD-type [IPR013083]", "Zinc finger, RanBP2-type superfamily [IPR036443]", "Zinc finger, Sec23/Sec24-type superfamily [IPR036174]", "Zinc finger, ZZ-type superfamily [IPR043145]", "Zinc-binding ribosomal protein [IPR011332]", "dUTPase-like superfamily [IPR036157]", "eRF1, domain 1 [IPR024049]", "eRF1, domain 2 superfamily [IPR042226]", "p53-like tetramerisation domain superfamily [IPR036674]", "p53-like transcription factor, DNA-binding [IPR008967]", "p53/RUNT-type transcription factor, DNA-binding domain superfamily [IPR012346]", "ssDNA-binding transcriptional regulator [IPR009044]", "tRNA (guanine-N1-)-methyltransferase, N-terminal [IPR029026]", "tRNA methyltransferase TRM10-type domain superfamily [IPR038459]", "tRNA modification GTPase MnmE domain 2 [IPR027368]", "tRNA-splicing ligase RtcB-like superfamily [IPR036025]", "tRNAHis guanylyltransferase Thg1 superfamily [IPR038469]", "von Willebrand factor A-like domain superfamily [IPR036465]"], "available_proteins": ["AAAS", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABHD10", "ABHD12", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR6", "ADAM17", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK6", "AKAP1", "AKAP13", "AKAP17A", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "ALYREF", "ANAPC1", "ANAPC5", "ANAPC7", "ANK3", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG4B", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5H", "ATP5O", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATXN10", "BABAM1", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAT2", "BCL2L12", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPTF", "BRCA1", "BRD2", "BROX", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BZW1", "C1QBP", "CACYBP", "CAD", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CDC23", "CDC27", "CDC34", "CDC37", "CDC42", "CDC5L", "CDC73", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CEBPZ", "CECR2", "CELF1", "CENPB", "CEP170", "CERS2", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHD4", "CHERP", "CHID1", "CHKA", "CHORDC1", "CHRAC1", "CHTF18", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLINT1", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT10", "CNOT3", "CNOT6", "CNOT7", "CNOT9", "CNP", "COA7", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPZ1", "CORO1B", "CORO1C", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2B", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYP51A1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF13", "DCAF7", "DCAKD", "DCPS", "DCTN1", "DCXR", "DDB1", "DDI2", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DENR", "DERL1", "DFFA", "DGCR8", "DGUOK", "DHCR24", "DHFR", "DHPS", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DOHH", "DPF2", "DPH2", "DPM1", "DPP9", "DPYSL2", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "ECE1", "ECH1", "ECHS1", "ECI2", "EDC3", "EDC4", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3B", "EIF3E", "EIF3G", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELOA", "ELOB", "ELP1", "ELP2", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "ENY2", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERH", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM120B", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FEN1", "FERMT2", "FH", "FKBP10", "FKBP14", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FOXK1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCN1", "GDI1", "GDI2", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GIGYF2", "GINS1", "GINS4", "GLA", "GLB1", "GLDC", "GLE1", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GNS", "GORASP2", "GOT1", "GOT2", "GPD2", "GPI", "GPRASP2", "GPS1", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGFL2", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIC2", "HIF1AN", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMCES", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOXA10", "HP1BP3", "HPRT1", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IDE", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP3", "IGF2R", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMPDH2", "INF2", "INTS11", "INTS14", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRS4", "ISOC1", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC2", "KLC4", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRR1", "KYAT3", "L2HGDH", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LDAH", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3BP", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LYAR", "LYPLA1", "MACF1", "MAGED2", "MAGT1", "MAP2K1", "MAPRE1", "MAPRE2", "MARC1", "MARK2", "MARS", "MAT2A", "MATR3", "MAU2", "MBD3", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED16", "METAP2", "METTL13", "MFN1", "MFN2", "MGEA5", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MINPP1", "MKI67", "MMAB", "MMS19", "MOB4", "MOGS", "MORF4L1", "MOV10", "MPI", "MPP2", "MPP6", "MPRIP", "MPST", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL38", "MRPL39", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL9", "MRPS11", "MRPS2", "MRPS25", "MRPS27", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MYBBP1A", "MYEF2", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPG", "NCBP1", "NCL", "NCOA5", "NDRG3", "NDUFA10", "NDUFA9", "NDUFAF1", "NDUFAF7", "NDUFS1", "NDUFS3", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4L", "NEK9", "NENF", "NEU1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL11", "NOL8", "NOL9", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NPTN", "NRBP1", "NRDC", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT12", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP98", "NUTF2", "NVL", "NXF1", "OAT", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OSBP", "OSBPL11", "OSBPL6", "OSBPL9", "OTUB1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAFAH1B1", "PAFAH1B3", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARN", "PARP1", "PARP2", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCMT1", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF6", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIR", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLAA", "PLBD2", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNO1", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1R10", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PPP6R3", "PPT1", "PQBP1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG2", "PSPC1", "PTBP1", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTRH2", "PTRHD1", "PUF60", "PUM3", "PUS1", "PUS7", "PWP1", "PWP2", "PYCR1", "PYCR2", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RABGGTA", "RABL6", "RAC1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM34", "RBM39", "RBM4", "RBM45", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "RECQL5", "REPS1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIF1", "RINT1", "RIOK2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF114", "RNF20", "RNF40", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA3", "RPAP3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPP30", "RPRD1A", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS8", "RPS9", "RPSA", "RRM1", "RRM2", "RRP12", "RRP7A", "RRP8", "RRP9", "RSF1", "RSL1D1", "RTCB", "RTN4IP1", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART3", "SBDS", "SCAF8", "SCCPDH", "SCFD1", "SCO1", "SCP2", "SCPEP1", "SCRIB", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERPINB6", "SERPINH1", "SET", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3B1", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SIN3A", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC3A2", "SLC6A15", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMU1", "SMYD3", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNX1", "SNX12", "SNX2", "SNX3", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SQLE", "SQSTM1", "SRCAP", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAG2", "STARD3", "STAT3", "STEAP3", "STIP1", "STMN1", "STOML2", "STRAP", "STRBP", "STRN4", "STUB1", "STX12", "STX7", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "TACO1", "TAF15", "TAGLN2", "TALDO1", "TAP1", "TAP2", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCE", "TBL2", "TBL3", "TCAF1", "TCEA1", "TCERG1", "TCF25", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TEX10", "TFAM", "TFRC", "THG1L", "THOC1", "THOC3", "THOC6", "THOP1", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TK1", "TKT", "TLN1", "TMED7", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX4", "TNPO1", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOX4", "TP53", "TP53BP1", "TPD52L2", "TPI1", "TPP1", "TPP2", "TPT1", "TRA2A", "TRA2B", "TRAP1", "TRAPPC5", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRMU", "TRNT1", "TROVE2", "TSC2", "TSFM", "TSG101", "TSN", "TSPAN6", "TSTA3", "TTC1", "TTC19", "TTC21B", "TTC26", "TTC37", "TTC38", "TTC4", "TTK", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBL5", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UCHL5", "UFC1", "UFD1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF3B", "UQCR10", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USO1", "USP10", "USP14", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIRMA", "VPS16", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR43", "WDR45B", "WDR46", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIZ", "WRAP53", "XAB2", "XPNPEP1", "XPO1", "XPO4", "XPO5", "XPO7", "XRCC1", "XRCC5", "XRCC6", "YARS", "YARS2", "YBX1", "YEATS2", "YEATS4", "YKT6", "YLPM1", "YME1L1", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBTB10", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3HAV1", "ZCCHC3", "ZFR", "ZFYVE16", "ZNF148", "ZNF281", "ZNF638", "ZNF687", "ZRANB2"], "leading_proteins": ["AARS2", "AARSD1", "ACOT7", "ACOT9", "ADI1", "AGK", "AGL", "AIFM1", "AIP", "AKAP1", "AKAP13", "AKT2", "ALKBH5", "ANKHD1", "ANKRD17", "ANP32B", "APLP2", "APP", "APRT", "ARCN1", "ARFGAP1", "ATP13A1", "ATP1B1", "ATP2B1", "BROX", "BSG", "CALU", "CAPN2", "CBX1", "CBX3", "CDC23", "CDC34", "CERS2", "CIAPIN1", "CLUH", "CMTR1", "CNOT10", "CNOT6", "CPVL", "CRNKL1", "CTPS2", "CTSA", "CYB5D2", "DCTN1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC9", "DRG2", "EEF1A2", "EEF1D", "EFL1", "EIF3L", "EIF5", "EIF5B", "EPHA7", "ERCC6L", "EXO1", "F11R", "FDPS", "FH", "FKBP14", "FKBP7", "FMR1", "FUCA2", "FUS", "FXR1", "GAA", "GALNT1", "GALNT2", "GBA", "GGCX", "GGH", "GLA", "GLB1", "GORASP2", "GTPBP1", "GUSB", "HBS1L", "HDAC1", "HEXA", "HEXB", "HLA-B", "HLA-C", "HLTF", "HPRT1", "HSD17B4", "HTRA2", "HUWE1", "ILKAP", "KDM1B", "KDM2A", "KIFBP", "KLC4", "KPNA1", "KPNA2", "KPNA4", "LEMD3", "LGALS3BP", "LIPA", "LNPEP", "LTA4H", "MAPRE2", "METAP2", "MPP6", "MSH3", "MSH6", "MTIF2", "MTOR", "NAGLU", "NAP1L1", "NAPG", "NECAP1", "NECAP2", "NECTIN2", "NISCH", "NPC2", "NTMT1", "NUB1", "NUCB1", "NUCB2", "NUDCD1", "NUDCD2", "P3H1", "P3H4", "P4HA1", "P4HA2", "PAK2", "PDLIM5", "PDPR", "PEPD", "PFDN5", "PIR", "PLOD3", "PNO1", "POLE", "POLRMT", "PON2", "PPAT", "PPT1", "PRMT1", "PRPF3", "PRPSAP1", "PRPSAP2", "PSMB2", "PSMB6", "PSMD3", "PTGES3", "PTRH2", "QKI", "RABGGTA", "RANBP1", "RARS2", "RCN2", "RIPK1", "RPL35A", "RPS3", "RPS5", "RUVBL2", "SARS2", "SART3", "SCPEP1", "SDF4", "SEPHS1", "SET", "SLC25A17", "SLC25A20", "SLC25A32", "SLC25A33", "SLIT2", "SMARCAD1", "SMYD3", "SQSTM1", "STXBP4", "SUPT16H", "TAF15", "TARS2", "TDRKH", "TJP1", "TJP2", "TMOD3", "TOP2B", "TRIM26", "TTC1", "TTC19", "TTC38", "TUBB4B", "TUBB6", "TUFM", "UBA1", "UBA2", "UBA3", "UBAP2L", "XPNPEP1", "YWHAQ"]} \ No newline at end of file diff --git a/interpro_ptm/advanced/idx2term.json b/interpro_ptm/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/basic/idx2term.json b/interpro_ptm/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/consensus.joblib b/interpro_ptm/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..2a1d51d8cc9b20be963664d36451f9d57d2bc830 --- /dev/null +++ b/interpro_ptm/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:e8a1045e6586366760833a714380bd7aabf1e55cb7433b7c11a4bf4edad6ab70 +size 55098 diff --git a/interpro_ptm/df_merge.tsv b/interpro_ptm/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..dd1ebfd47b9e5d959f2adf722e930f502d75b412 --- /dev/null +++ b/interpro_ptm/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_ptm/metrics.json b/interpro_ptm/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..0378c4404bf7784078a6fb6043fea95be47ab5e9 --- /dev/null +++ b/interpro_ptm/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2453, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 2.0 +} \ No newline at end of file diff --git a/interpro_ptm/paths.json b/interpro_ptm/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..f02e776607e7628891c37de7d2c3e96ab5befd85 --- /dev/null +++ b/interpro_ptm/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_ptm/fragment/C334/C334_val_log2fc"} \ No newline at end of file diff --git a/interpro_ptm/result.tsv b/interpro_ptm/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..ee6625d910c093cf61c3ef14749d9795bc982c0c --- /dev/null +++ b/interpro_ptm/result.tsv @@ -0,0 +1,2 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +P-type ATPase, phosphorylation site [IPR018303] 0.6338890394308648 0.8748449833693627 0.3816582575236689 0.8538111459171409 0.3816582575236689 5 P20020,Q9HD20 2 diff --git a/interpro_ptm/selections.json b/interpro_ptm/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..44011f695c0bd5a8daf8db2755a287245389c33d --- /dev/null +++ b/interpro_ptm/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["EGF-type aspartate/asparagine hydroxylation site [IPR000152]", "P-type ATPase, phosphorylation site [IPR018303]", "Phosphopantetheine attachment site [IPR006162]", "Translation elongation factor, IF5A, hypusine site [IPR019769]"], "available_proteins": ["ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "EIF5A", "FASN", "SLIT2"], "leading_proteins": ["ATP13A1", "ATP2B1"]} \ No newline at end of file diff --git a/interpro_repeat/advanced/idx2term.json b/interpro_repeat/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_repeat/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_repeat/basic/idx2term.json b/interpro_repeat/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..de1a6f48db259f6de5b7d0af920c439fb0ff1c80 --- /dev/null +++ b/interpro_repeat/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Leucine-rich repeat [IPR001611]", "1": "HAT (Half-A-TPR) repeat [IPR003107]"} \ No newline at end of file diff --git a/interpro_repeat/basic/plot_0.png b/interpro_repeat/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..28f1d123e134b8331ced1d5d8cfbbf1dbadce58e --- /dev/null +++ b/interpro_repeat/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:11b4a02b9efe5941db293c640b8d8f4134b9f8acfc085c428ef0c4ce8ef195ae +size 137029 diff --git a/interpro_repeat/basic/plot_1.png b/interpro_repeat/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..30be085f9c386b7ba95f5394684c8369bb445ef3 --- /dev/null +++ b/interpro_repeat/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:12a3cb022db7c6bcd6a6bfef6be5dabf584806de83fcbbb824bccda400fe328a +size 133419 diff --git a/interpro_repeat/consensus.joblib b/interpro_repeat/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..ea8ce1f03b2eb646ccc2b82ae5bd2e72291e0a3d --- /dev/null +++ b/interpro_repeat/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:39d324eb04378351f5ee724ffb47cd601088c0e1a5054157443a2801cd9dff54 +size 68753 diff --git a/interpro_repeat/df_merge.tsv b/interpro_repeat/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..dd1ebfd47b9e5d959f2adf722e930f502d75b412 --- /dev/null +++ b/interpro_repeat/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_repeat/metrics.json b/interpro_repeat/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..fcdba14378d426a36d245966f65c61deeb14f3d6 --- /dev/null +++ b/interpro_repeat/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2453, + "annotations_size": 68, + "title": "Average number of proteins per term", + "value": 5.25 +} \ No newline at end of file diff --git a/interpro_repeat/paths.json b/interpro_repeat/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..f8345f61dc43faba99f76952369c13115ec43159 --- /dev/null +++ b/interpro_repeat/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_repeat/fragment/C334/C334_val_log2fc"} \ No newline at end of file diff --git a/interpro_repeat/result.tsv b/interpro_repeat/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..33e6249dbe361479d8d926dcfd5881aae0161fb3 --- /dev/null +++ b/interpro_repeat/result.tsv @@ -0,0 +1,12 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +HEAT repeat [IPR000357] 0.7834080595114243 1.4160643660197003 0.1567566599655534 0.9999907785642108 0.2599866555526252 3 Q8TEX9 1 +Mitochondrial substrate/solute carrier [IPR018108] 0.5351458119158323 1.2475264634876817 0.2122045231105751 0.9999999096107376 0.3205690755686176 18 Q9H2D1,O43772,O43808,Q9BSK2 4 +Proteasome/cyclosome repeat [IPR002015] 0.6478988168094688 1.195208705196917 0.2320054982321686 0.999999983991467 0.3356675293571802 2 Q99460 1 +Hexapeptide repeat [IPR001451] 0.6417788657690784 1.1677919065311504 0.2428907135578364 0.999999993935668 0.3440951775402682 2 Q96IJ6 1 +Ankyrin repeat [IPR002110] 0.554155666344207 1.099778719096534 0.2714285466799442 0.99999999955526 0.3766763504946164 12 Q8IWZ3,O75179 2 +Leucine-rich repeat [IPR001611] 0.4567661738467171 0.7948765333965262 0.4266853259536101 1.0 0.5636681149792898 17 Q9ULM6,Q9Y2I1,O94813,Q92696,Q92688 5 +Leucine-rich repeat, typical subtype [IPR003591] 0.4090206191940757 0.4220561447364047 0.6729840373017111 1.0 0.7627152422752725 10 O94813 1 +HAT (Half-A-TPR) repeat [IPR003107] 0.3883892068683703 0.1905560541852392 0.8488734228694346 1.0 0.9310224637922832 7 Q9BZJ0,O94906,Q15020,Q14690,Q9NYH9,Q9HCS7 6 +Atypical Arm repeat [IPR032413] 0.401388321763988 0.1525888666672217 0.8787225052914058 1.0 0.9355834858993308 4 P52294,O00629,P52292 3 +Filamin/ABP280 repeat [IPR001298] 0.3017558187015159 0.0383548220522364 0.969404781234867 1.0 0.969404781234867 4 Q14315,P21333,O75369 3 +Filamin/ABP280 repeat-like [IPR017868] 0.3017558187015159 0.0383548220522364 0.969404781234867 1.0 0.969404781234867 4 Q14315,P21333,O75369 3 diff --git a/interpro_repeat/selections.json b/interpro_repeat/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..b8511f57a6e605e52a3cb78347d4864a9535dfca --- /dev/null +++ b/interpro_repeat/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Ankyrin repeat [IPR002110]", "Annexin repeat [IPR018502]", "Armadillo [IPR000225]", "Atypical Arm repeat [IPR032413]", "BIR repeat [IPR001370]", "Beta-propeller repeat TECPR [IPR006624]", "Calponin repeat [IPR000557]", "Cation-independent mannose-6-phosphate receptor repeat [IPR000479]", "Chromosome region maintenance repeat [IPR041123]", "Clathrin, heavy chain, propeller repeat [IPR022365]", "Clathrin, heavy chain/VPS, 7-fold repeat [IPR000547]", "Cysteine-rich Golgi apparatus protein 1 repeat [IPR001893]", "Cysteine-rich Golgi apparatus protein 1 repeat, eukaryote [IPR017873]", "Exportin-1, repeat 2 [IPR041235]", "Exportin-1, repeat 3 [IPR040485]", "Filamin/ABP280 repeat [IPR001298]", "Filamin/ABP280 repeat-like [IPR017868]", "G-protein beta WD-40 repeat [IPR020472]", "GTF2I-like repeat [IPR004212]", "HAT (Half-A-TPR) repeat [IPR003107]", "HEAT repeat [IPR000357]", "HEAT repeat associated with sister chromatid cohesion protein [IPR026003]", "HEAT, type 2 [IPR021133]", "HUWE1/Rev1, ubiquitin binding region [IPR025527]", "Hexapeptide repeat [IPR001451]", "Hs1/Cortactin [IPR003134]", "Huntingtin, middle-repeat [IPR024613]", "Importin repeat 4 [IPR041653]", "Importin repeat 6 [IPR041389]", "Importin repeat [IPR040928]", "KI67R [IPR012568]", "Kelch repeat type 1 [IPR006652]", "Kinesin light chain repeat [IPR015792]", "Leucine rich repeat 4 [IPR025875]", "Leucine-rich repeat [IPR001611]", "Leucine-rich repeat, cysteine-containing subtype [IPR006553]", "Leucine-rich repeat, typical subtype [IPR003591]", "Low-density lipoprotein (LDL) receptor class A repeat [IPR002172]", "Microtubule associated protein, tubulin-binding repeat [IPR001084]", "Mitochondrial substrate/solute carrier [IPR018108]", "NHL repeat [IPR001258]", "Nebulin repeat [IPR000900]", "Neuraxin/MAP1B repeat [IPR000102]", "P120R repeat [IPR012586]", "PBS lyase HEAT-like repeat [IPR004155]", "PFTB repeat [IPR001330]", "Paired amphipathic helix [IPR003822]", "Pentatricopeptide repeat [IPR002885]", "Plectin repeat [IPR001101]", "Proteasome/cyclosome repeat [IPR002015]", "Protein of unknown function DM15 [IPR006607]", "Protein prenyltransferase, alpha subunit [IPR002088]", "Proteinase inhibitor I27, calpastatin [IPR001259]", "Pumilio RNA-binding repeat [IPR001313]", "Putative TPR-like repeat [IPR031545]", "Pyrrolo-quinoline quinone repeat [IPR002372]", "RNA helicase p68 repeat [IPR012587]", "RNA polymerase II, heptapeptide repeat, eukaryotic [IPR000684]", "Regulator of chromosome condensation, RCC1 [IPR000408]", "Sel1-like repeat [IPR006597]", "Spectrin repeat [IPR002017]", "Spectrin/alpha-actinin [IPR018159]", "Tetratricopeptide repeat 1 [IPR001440]", "Tetratricopeptide repeat 2 [IPR013105]", "Tetratricopeptide repeat [IPR019734]", "Vesicle tethering protein p115, armadillo tether-repeat [IPR041209]", "WD40 repeat [IPR001680]", "Wolframin, Sel1-like repeat [IPR045458]"], "available_proteins": ["AAAS", "ACTN1", "ACTN4", "AIP", "ANAPC5", "ANAPC7", "ANK3", "ANKHD1", "ANKRD17", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP2B1", "ARMC6", "ARMCX3", "ARPC1A", "ARPC1B", "ASPH", "BIRC6", "BOP1", "BUB3", "CAST", "CDC23", "CDC27", "CHAF1B", "CKAP5", "CLASP1", "CLPB", "CLTC", "CNN2", "CNN3", "CNOT10", "CNOT6", "COA7", "COPA", "COPB2", "CORO1B", "CORO1C", "CRNKL1", "CSTF1", "CSTF3", "CTNNB1", "CTNND1", "CTTN", "DCAF13", "DCAF7", "DDX5", "DNAAF5", "DNAJC3", "DNAJC7", "DOHH", "DSP", "DST", "DYNC1I2", "EDC4", "EIF2B5", "EIF3I", "ELP2", "EMC1", "EMC2", "EML4", "EPPK1", "FKBP4", "FKBP5", "FKBP8", "FLII", "FLNA", "FLNB", "FLNC", "FNTB", "GCN1", "GEMIN5", "GLG1", "GLS", "GMPPA", "GRWD1", "GTF2I", "GTF3C2", "GTF3C3", "HCFC1", "HECTD1", "HERC2", "HTT", "HUWE1", "IFIT5", "IGF2R", "ILK", "IPO4", "IPO5", "JUP", "KDELC2", "KDM2A", "KEAP1", "KLC2", "KLC4", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "LARP1", "LASP1", "LLGL1", "LRBA", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "MACF1", "MAP1B", "MAP4", "MAU2", "MED16", "MKI67", "MRPS27", "MTCH1", "MTCH2", "MTPN", "NAA15", "NASP", "NEK9", "NHLRC2", "NIPBL", "NISCH", "NLE1", "NOP2", "NUDT12", "NUP214", "NUP37", "NUP43", "NXF1", "OGT", "P4HA1", "P4HA2", "PAFAH1B1", "PDCD11", "PHIP", "PLAA", "PLEC", "PLRG1", "POLR2A", "PPID", "PPP2R1A", "PPP2R2A", "PPP5C", "PREB", "PRKCSH", "PRPF19", "PRPF4", "PRPF6", "PSMD1", "PSMD10", "PSMD2", "PTCD1", "PTCD3", "PUM3", "PWP1", "PWP2", "RABGGTA", "RACK1", "RAE1", "RAI14", "RANBP2", "RANGAP1", "RCC1", "RCC2", "RPAP3", "RRP9", "SART3", "SCRIB", "SEC31A", "SEH1L", "SEL1L", "SGTA", "SHOC2", "SIN3A", "SKP2", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLIT2", "SMU1", "SNRNP40", "SNRPA1", "SPTAN1", "SPTBN1", "SRP72", "STIP1", "STRAP", "STRN4", "STUB1", "SUGT1", "SYNE2", "TAGLN2", "TBL2", "TBL3", "TEX10", "THOC3", "THOC6", "TMTC3", "TOMM34", "TOMM70", "TTC1", "TTC19", "TTC21B", "TTC26", "TTC37", "TTC4", "UNC45A", "USO1", "UTP15", "UTP18", "UTP4", "UTP6", "UTRN", "VPS18", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR43", "WDR45B", "WDR46", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WRAP53", "XAB2", "XPO1", "YTHDC2"], "leading_proteins": ["ANKHD1", "ANKRD17", "ANP32B", "CNOT6", "CRNKL1", "FLNA", "FLNB", "FLNC", "GMPPA", "IPO4", "KPNA1", "KPNA2", 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11 27 3.1744021560797573 0.0015014550248322 7.968446601941747 31.24514563106796 0.6061616104105989 0.3954837799611526 3.566493820193545 3.4119437173329663 1.31706945612869 0.333413728218646 5.6297856107401086e-06 3.359460586211764e-05 2.491609193401941e-06 0.001821835634791 +Steroid metabolic process 13 52 3.141821042908403 0.0016790062418368 17.82766990291262 66.9247572815534 0.9974586731388552 0.3270410156332073 6.090491666967852 5.93996409793671 1.7133199907504504 0.3720334828404655 0.0009563326986827 3.546525444604524e-08 2.7062312459835687e-05 0.0005904673849418 +Behavior 11 62 3.140646650812575 0.001685752851078 16.990291262135923 75.04126213592232 0.2909440827671418 0.5405324846032677 5.526186812971979 8.403983472903677 1.109438409605415 0.3578193814797769 0.0003184240165587 6.431723561727764e-05 0.006468916936205 0.0697616334260515 +Carbohydrate metabolic process 13 112 3.135773974232939 0.0017140124755514 34.21844660194175 139.29611650485438 -0.5656770110174321 0.5032146838847018 13.810993563752842 11.927763340900242 1.1407068088015644 0.3581886500202023 1.4021953035350876e-06 0.0002768940791281 0.0099770899007244 0.1476361053200586 +Biological process involved in symbiotic interaction 17 64 3.0715170675849865 0.0021297398800153 16.524271844660195 76.43932038834951 -0.5010535102907213 0.5207152694072219 8.300596142112324 6.579514214979575 1.032159450203337 0.3396665187616686 2.4144826223747477e-05 0.0003631171705617 0.0001220449304851 0.0028543564325084 +Biological process involved in interaction with host 10 44 3.065965501595898 0.0021696834715656 10.618932038834952 53.64563106796116 -0.1735979361033036 0.5744529678567812 5.9122163164147095 5.1849909737500735 1.0319123463248503 0.3347248046760931 3.518011139015801e-05 0.0002535620490264 1.4038900057479656e-05 0.0096234210372383 +Chemical homeostasis 23 133 3.0413496890904894 0.0023552012573266 43.762135922330096 177.7597087378641 0.7082111793088889 0.511106347874914 13.668464281922288 17.87763227716401 1.3204137511810292 0.4179418895476048 0.0003133107729121 0.0030528844783825 0.0024218608878641 0.0018947681179268 +Endocytosis 10 84 3.0187059092996447 0.0025385682660781 25.6626213592233 116.14077669902912 0.4088637809343856 0.6347066552957155 9.675324480764845 15.608206311139906 1.1645342915127963 0.3689266363473043 5.731293039161314e-06 0.0005845838159098 0.0051274981178352 0.0017468381389375 +Sphingolipid metabolic process 11 22 3.010239439248521 0.0026104181495443 12.631067961165048 29.174757281553397 1.3566630100256978 0.1614907042591146 4.986857078326301 3.461093559903884 2.232073980338918 0.2503191978902473 3.265837219796803e-07 2.3848518114840213e-08 2.795163751979683e-06 0.0019984236571286 +Cellular ion homeostasis 14 67 2.99292440437654 0.0027631818297217 24.48543689320388 87.34708737864078 0.921352068115914 0.4223079442129951 9.212290310790763 8.933596252465952 1.5207794649628892 0.4002972861975121 0.002061165852098 0.0176637687567794 0.0028526794145662 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23.79368932038835 1.067589638534915 0.1668002350701783 2.8744208086829883 3.077266940940983 2.0111064761459874 0.2496786569477077 1.3977145854214794e-08 5.6969819732787125e-09 1.759622064330642e-07 4.816014037368799e-06 +Ion homeostasis 16 78 2.858845313669598 0.0042518606229304 28.021844660194176 105.69174757281552 0.8349951537384392 0.4299135801564597 10.40966729997928 11.411952082971936 1.4722934854811005 0.3963893325418664 0.0054120035953329 0.0443966784961674 0.0031951015108501 0.0063989229784577 +Locomotory behavior 7 26 2.842451289552831 0.004476807155781 7.186893203883495 29.01456310679612 0.367578136549174 0.4129867938447028 2.855164467106169 2.964970497634466 1.254834886476281 0.3178953925587394 9.607024526105988e-05 3.8564244843452064e-05 0.0005044535466369 0.0021887934750228 +Neuron death 11 62 2.783503492254526 0.005377528356135 14.20388349514563 73.25242718446601 0.8007457732231772 0.4829929240620625 5.370919943079612 7.537889337352574 0.9625497526284538 0.3667297831171348 0.0938642261720824 0.0059519165214771 0.0080109113713409 0.1234425467989061 +Inflammatory response 13 50 2.7743845965882072 0.0055306252362861 13.228155339805824 68.3883495145631 0.4116983048649594 0.5194837377797665 5.6022172704029956 8.769134982645609 1.0984550499812151 0.3566163019943059 0.0473074236053336 0.0196533573166611 0.0085350934385942 0.138643351137438 +Receptor mediated endocytosis 4 41 2.7596725454201065 0.0057859323952198 10.939320388349516 54.74514563106796 0.2974076350556154 0.559708876603857 5.491273529430237 7.364675641797722 1.1085365989015756 0.3550743208777513 0.0008508092959424 0.0167262101527802 0.0327823583833714 0.0683581098638498 +Adult behavior 5 17 2.7586095323216657 0.0058047848290823 4.924757281553398 19.364077669902912 0.6031935344655648 0.4116465050786389 2.137657889318908 2.190772988063693 1.071812274679601 0.3090358289458393 0.0039147102095996 0.0004254356855182 0.0049509879168996 0.0133576799768756 +Nervous system process 10 80 2.7492774052651563 0.005972681455775 23.060679611650485 100.46844660194176 0.466210961761844 0.5050785047376438 7.1617042179301365 12.55034423055404 1.1784062094355452 0.368401069133876 0.0007768453592291 0.0022016450883694 0.1292249125282314 0.3545013692625377 +Lipid localization 19 54 2.746410067245084 0.0060251402322499 20.1504854368932 74.27912621359224 1.3966421040883936 0.3001252105784707 7.306180038477171 9.39465098860316 1.572418240819249 0.3627304234720817 0.0006942263533444 5.887100741577382e-05 0.0003359997886931 0.0011718435224587 +Protein processing 7 39 2.73116993021357 0.0063109921914414 12.08252427184466 45.980582524271846 0.9011703887478908 0.3916089016010577 4.43430858840224 4.931040148104543 1.176660792763282 0.3507158233798557 0.0046881619119119 0.0004192854247962 0.0069786833473203 0.0182746609589435 +Neuromuscular process 5 21 2.7213506994786023 0.006501574639373 6.682038834951456 25.487864077669904 0.5107907507501308 0.3958015985368521 2.5973040014911133 3.0533044809467955 1.2106508695866462 0.3144907539964949 1.6486743933969312e-05 4.32244292682785e-05 0.0010864364912465 0.0003156996925404 +Secondary alcohol metabolic process 10 33 2.6861617039128767 0.0072278099401064 12.097087378640778 42.24514563106796 1.5200936296432006 0.2566232504859334 4.463475425703621 3.883072640851752 1.3223501002339118 0.3210874999447533 0.0008444118761584 1.5894680812924814e-07 8.037172447811301e-06 0.0032740802464565 +Neuron apoptotic process 8 45 2.651822246575435 0.008005867673003 11.191747572815531 49.65533980582524 0.9007291731588002 0.4299023129629146 4.0102574614548505 4.518854312987721 0.9862249081516458 0.3541854094791909 0.0357664341382327 0.0032893365301628 0.0103405593254548 0.1871386191885464 +Aminoglycan metabolic process 7 12 2.646393814901985 0.0081355042406408 6.650485436893204 15.218446601941748 0.5538240398360251 0.1973407167351751 2.4739761552565955 2.4752855115427597 1.8355272359461776 0.2521795038965069 1.2114709611692025e-05 2.2342114992536898e-06 1.7527360716197133e-05 0.002960790762684 +Cellular monovalent inorganic cation homeostasis 10 17 2.635112133065752 0.0084109491944612 8.191747572815533 25.12378640776699 1.1978511848260835 0.2636491484517694 3.558748260132903 2.9783551257949803 1.4212259473978417 0.3021468238591936 0.0032700867405931 0.0029632963559562 0.0001087627785303 0.0001532274543384 +Cellular homeostasis 16 107 2.6159212041050792 0.00889870905124 35.03155339805825 140.69660194174756 0.4666088113804902 0.5685618966047314 11.62423291193178 14.777892439656425 1.1736922314243927 0.3887657095146841 0.0042940255483825 0.0555883679460095 0.0156345834237827 0.0051633253310875 +Ceramide metabolic process 9 14 2.600769697336602 0.0093014874072976 8.191747572815533 19.060679611650485 1.0632949889077032 0.1865092544415649 3.2982239784478966 2.5917545738626013 1.8901201919357584 0.2494992632187684 7.984541534446868e-06 7.172502607212519e-08 9.916410004075554e-07 0.0003835948931416 +Adult locomotory behavior 4 14 2.5996889721560223 0.0093308288278768 3.95873786407767 14.822815533980584 0.7389907423501648 0.3383620981823156 1.833016072372531 1.4878680371825237 1.1254592435779416 0.2897204029443448 0.0009649225463882 0.0006071735045487 0.0027313950543102 0.0029107376891594 +Anatomical structure homeostasis 7 30 2.581414869473064 0.0098396255979913 8.04611650485437 37.74757281553398 -0.8265793858068656 0.3669467507401432 3.743643086519086 4.240279452693054 1.2249317969197393 0.3202756345948493 0.0434644049612363 0.004818495856418 0.0423793981021662 0.0493707589529366 +Membrane lipid catabolic process 7 11 2.577554654948188 0.0099502144596566 5.854368932038835 11.361650485436892 0.500872843713425 0.1363587272813367 1.9603237645724247 0.9867004907377388 2.113024793917032 0.2289617793743788 3.752953969462557e-10 7.366515461627419e-12 1.1057177661886282e-08 2.2920785933487533e-06 +Cognition 4 29 2.5669720607045003 0.0102590878158874 8.381067961165048 35.51456310679612 0.106014143429431 0.585314562092836 3.4293041589801794 4.867395144092575 0.9639094447868622 0.3250247192097197 0.0059901365409964 0.0154677756890255 0.0725768331180189 0.4438365171488032 +Neuron projection guidance 4 17 2.566051812297245 0.0102863461885034 5.662621359223301 23.189320388349515 0.4437647002001748 0.5678522712486597 2.931294310088859 4.519975354803488 0.8912373776728286 0.311775964869191 0.0277741900197473 0.0425585438658712 0.1099190288620697 0.6444915411028371 +Negative regulation of developmental process 12 78 2.56566836369943 0.0102977232054535 22.606796116504853 101.0631067961165 -0.1690080981071963 0.631864255638976 9.924264293838888 11.641526693087815 0.7921494883239464 0.3166468220789081 0.0683277707777694 0.152518192746982 0.2111174355472491 0.8422004445573121 +Viral life cycle 14 77 2.565561742176779 0.0103008886824134 19.410194174757283 93.29611650485435 -0.3045293626460413 0.6588462721769274 10.482263936948428 7.880459085859297 0.7518829773930114 0.3155541175306531 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0.0141210655184214 +Long term synaptic potentiation 3 9 2.518954721889342 0.0117703791465706 3.012135922330097 9.730582524271844 0.4069972937780292 0.4936148854997918 1.5319726166057843 1.7661148877091215 0.9317897164603502 0.2968501206773379 0.0195557545343205 0.0008752645247723 0.0219504556074559 0.1661443482772651 +Circulatory system process 18 58 2.5086499011741 0.0121193534348067 17.152912621359224 72.00970873786407 0.7968086684699157 0.4206667688960129 5.8797345113877215 8.195718922280731 1.282615010632819 0.3676426088525382 0.001113849107184 0.009600078757877 0.0352219187879782 0.0036742344914261 +Positive regulation of synaptic transmission 3 17 2.5070557834766083 0.0121741496958494 4.813106796116505 17.475728155339805 0.4358203865992658 0.5836764637458288 2.251541663478826 2.30909834121491 0.7613404062503117 0.3040027846338212 0.046072228335376 0.0048690104254232 0.0279194128393474 0.0539169814954352 +Taxis 9 48 2.5049118834474333 0.0122481903308904 15.383495145631068 66.66504854368932 0.0159573551720752 0.6551887547826701 6.206676597495536 8.676742809046639 0.9038937835622892 0.3260534579455081 0.0418320906997474 0.1230036620674163 0.0643461146778974 0.4371148228894264 +Negative regulation of growth 3 24 2.4896567576139192 0.0127866517122725 5.817961165048544 30.390776699029125 0.1801984393176988 0.6389493459236367 3.663433547604644 3.7005919729330703 0.7775873943572781 0.3097525958014036 0.0272445176770422 0.0415903132976506 0.4091593155419392 0.4752821060656034 +Neuron development 25 139 2.488926914215578 0.0128129302310475 34.62135922330097 181.34708737864077 0.2741713926873628 0.7656699386252992 12.599789260723686 22.778234719870852 0.7085731328386405 0.3174955318913259 0.045738063410274 0.067075206287195 0.153240772675646 0.2584850482420874 +Organophosphate ester transport 8 21 2.4513756224118195 0.0142311359363447 10.29126213592233 27.364077669902912 1.4948680330369015 0.1889391065154625 4.84293313185659 4.31957284765524 1.6451867819665518 0.2532208690981375 0.0067553656037119 0.0074628704993106 0.0125771724555126 0.0145017950635795 +Myeloid leukocyte differentiation 4 22 2.445973483774054 0.0144461624601364 6.978155339805825 29.5873786407767 0.2011011027578964 0.6062202255251892 3.5082438965963396 4.0029886798733605 0.8431092642014025 0.3149214169729679 0.016988771410235 0.0046331843911543 0.1352180343943975 0.0926465922135826 +Regulation of ph 6 12 2.4446874421884703 0.0144977723178578 6.890776699029126 20.859223300970875 1.2151699598837196 0.2373503364294603 2.930458126920059 2.7746402510870145 1.4154672965603718 0.2873526492076106 0.002071073147083 0.0016441077117893 0.000249328663123 0.0034550800173777 +Regulation of cellular ph 6 12 2.4446874421884703 0.0144977723178578 6.885922330097087 20.844660194174757 1.215766922704761 0.2375185297794358 2.9319293283093293 2.765976649626597 1.4143296516981956 0.2875299337708636 0.0017444833819082 0.0013159065844779 0.0001703692479783 0.0023530303459661 +Axon development 12 62 2.43228322806072 0.0150039696284756 15.014563106796116 75.88349514563107 0.4221802741874887 0.6742105443551618 6.65661081388802 8.797672872875632 0.8036898770047755 0.340363217999487 0.0548311973292591 0.0678972004905505 0.0556492115363729 0.3587953518376013 +Protein maturation 12 59 2.4301853650827474 0.0150911024746478 16.635922330097088 69.29611650485437 0.7279397561088901 0.5092233260742579 5.6828366082703345 6.923625268615643 1.0037762420957868 0.3621314209884535 0.0166552464814746 0.0007831431684808 0.0012956173479587 0.0044064063082496 +Cellular response to inorganic substance 7 30 2.414175562280975 0.0157708612637526 8.021844660194175 38.55582524271845 0.3118217467450566 0.6862388564014436 3.7787099682845775 5.080353367472772 0.6826079048933258 0.3095344385107431 0.1153703567090803 0.0293678148741552 0.0086433174552491 0.1273961443273763 +Positive regulation of response to external stimulus 9 43 2.413831794971892 0.0157857479428433 14.03640776699029 59.237864077669904 -0.0988246792844902 0.6482245236244654 5.442206033708916 6.922365840945858 0.8603956617533591 0.3163763423285246 0.0117205067001905 0.0324966056214957 0.0133158215397504 0.0315090665936589 +Vascular process in circulatory system 9 25 2.369255222175204 0.0178239490165017 8.218446601941748 31.361650485436893 0.5302527350177477 0.4259259059419516 3.6564678051714665 4.365329555745678 1.181021277396986 0.3310828049268227 0.0020843857952621 0.0234884289208764 0.0543047842319261 0.0078242583094151 +Lipid homeostasis 7 18 2.353313092599078 0.0186069595963307 7.665048543689321 25.939320388349515 0.8425417577103904 0.3366972259521467 2.992619034719237 3.7336969269092393 1.1648658675422845 0.295769208633365 0.0077423266249519 0.0088607173186582 0.0521205227118809 0.019537009262742 +Regulation of response to external stimulus 19 95 2.353102893582156 0.0186174816090054 27.32766990291262 129.63349514563106 0.3937649860570471 0.6986677015868525 9.316542933972368 15.399506498758855 0.8616366228871625 0.3591499966721317 0.059871605543297 0.0620427223646877 0.0046531024479186 0.0518095261964178 +Mononuclear cell migration 5 18 2.344720323449487 0.0190413567130374 6.058252427184466 23.645631067961165 0.0105016163762546 0.6303901682999394 3.102067092594892 2.7844323365283423 0.8660601863335294 0.3059427019687199 0.0040870836872518 0.0004567644770011 0.0010864364912465 0.0145727731801729 +Lysosomal transport 9 29 2.339387694558563 0.0193153778079295 10.274271844660197 41.317961165048544 0.2711798693300527 0.4597127484771267 4.560810075793522 6.516846556965687 1.3243780303643906 0.3539546843782676 0.0001475178115677 0.0035077991751912 0.0038734524621509 0.0046604368942746 +Regulation of synapse structure or activity 3 28 2.3127486478523265 0.020736462637825 6.665048543689321 33.640776699029125 0.4177416009353497 0.6162292560215563 4.025337439581666 3.7073905955276114 0.8008691737125054 0.3301048213868146 0.1201931014379405 0.031778301752159 0.3480206421160741 0.2458165306100975 +Leukocyte migration 9 33 2.3066323496112013 0.0210753245324248 10.118932038834952 46.80582524271845 0.3575882448711393 0.6313812887885496 4.534434682359551 5.391125848207169 0.8213013384586727 0.3308801783294869 0.0293962749000691 0.0110705878241367 0.0019118285521962 0.0356137871725309 +Cell maturation 2 19 2.3016149763920524 0.0213568948049893 5.558252427184466 23.611650485436893 0.3784230404296081 0.5141541830151944 2.6030237932680045 3.55055857689134 0.9250478571653724 0.3120408106541015 0.0677466229044455 0.0537433156025904 0.3575433799302857 0.8046349163957593 +Glycosphingolipid metabolic process 6 7 2.301229258553688 0.0213786759111922 4.764563106796117 9.184466019417476 0.4485135251287195 0.1553285492394019 1.7516723087054535 1.7320372023153958 1.93068386398988 0.2217231968869004 1.0219321391520157e-08 2.44783676369918e-08 1.1819822974309158e-05 0.0008961412475066 +Ceramide catabolic process 6 7 2.301229258553688 0.0213786759111922 3.8592233009708736 6.531553398058253 0.1286784152295923 0.1423502941444668 1.429436503356119 0.7012295128365029 2.0219843992394857 0.2259194528389771 1.7826192739143463e-09 5.369773771670297e-12 3.399976877027078e-09 4.068112400838954e-07 +Sterol homeostasis 6 9 2.298428280046711 0.021537425487258 3.2597087378640777 11.594660194174756 0.7425754872590924 0.2773502445350785 1.6018884221780605 1.6170423171351411 1.3033948892752858 0.2615762483252933 0.0008295914112261 0.0004978205073231 0.0021676616340201 0.0021434540231206 +Cell recognition 2 19 2.2961962584431657 0.0216646623876883 5.29126213592233 22.859223300970875 0.9056944851933356 0.3618031966115522 2.859598274322472 2.538937048941188 0.9847101891513528 0.3060121099700091 0.0358926009784828 0.1202677732034906 0.1865630132096767 0.1763957549795013 +Striated muscle cell differentiation 14 36 2.286656437252701 0.0222158842780857 9.233009708737864 41.963592233009706 0.2578497820814549 0.6057609991810756 4.193624109843778 4.66250637925984 0.8487717701871332 0.3193425984162805 0.1586635621104183 0.4175121848778135 0.0647054193800592 0.0018765123351574 +Multi multicellular organism process 5 20 2.2854734947244664 0.022285078866733 5.817961165048544 26.4004854368932 0.4199141861061661 0.4886319217993659 2.805744405393114 2.878999920293513 0.979235550100524 0.3132681877599969 0.0650462755169659 0.2027827245191691 0.017553407397255 0.1209466411518048 +Regulation of blood pressure 3 15 2.253218477993673 0.0242453768879007 5.762135922330097 17.737864077669904 1.3077123393993415 0.1882731913471478 2.2751770017499977 2.3871059987956724 1.372929386780725 0.2480453688154592 0.0028326312129738 0.0191373699896123 0.0528261722730647 0.0626099192975905 +Cellular carbohydrate catabolic process 2 16 2.241438953180082 0.0249976556918636 4.094660194174757 17.519417475728154 0.0720112229026999 0.5230835350302091 2.73830622849908 1.2452284270055651 0.9511421553520558 0.2982026173853891 0.0087935329278829 0.0027797273347076 0.0329460998536745 0.0507616506254266 +Negative regulation of neuron apoptotic process 3 22 2.231818993236234 0.0256269284992785 5.757281553398058 26.135922330097088 0.5817179538337637 0.4854643114827585 2.727835727399863 2.4377633537168184 0.9011837787919588 0.3153742372034477 0.0637102717405072 0.0493235058567373 0.1493271948426602 0.5924623994482376 +Phospholipid transport 2 9 2.230430621821129 0.025718868546948 4.038834951456311 13.844660194174756 0.8595089147672731 0.22382450694892 1.931709490395295 2.5542930986961077 1.4491821424024287 0.2459407475876757 0.0019583087959773 0.0135653143077038 0.0354428499477605 0.2373860395762566 +Transition metal ion homeostasis 5 19 2.22030302153041 0.0263982049679234 6.640776699029126 24.57281553398058 0.9239194315613378 0.3015424973151205 2.934079531592402 2.8081087224394015 1.2471169312381896 0.2974369333820005 0.0069945898038035 0.0437228444640497 0.0133275956191841 0.0053731990090933 +Cellular transition metal ion homeostasis 2 15 2.2131069808871446 0.0268902709432461 5.893203883495145 20.42233009708738 0.9608801516152976 0.3243056832171095 2.800529150274697 2.6932649561537056 1.130076157725316 0.3011842711337114 0.0039147102095996 0.0257983671639557 0.0740730415771438 0.0133576799768756 +Proteolysis 30 323 2.211052031862209 0.0270322341309343 82.13349514563107 384.1650485436893 0.3937128320128939 0.7591937859483255 23.57335472164496 35.5242559243431 1.030244592288769 0.3605545225308969 0.0049215832407042 0.001527182826094 0.0075819333416532 0.0545029703092755 +Regulation of long term synaptic potentiation 3 7 2.206230431677564 0.0273678695468038 2.191747572815534 6.026699029126213 0.6105178624452509 0.3860292464291884 1.2788913032023987 1.4948993461258857 1.1199694698848182 0.3107967468650517 0.0060718409625537 7.961405550860943e-05 0.00251045639703 0.0274602362801676 +Negative regulation of neuron death 5 34 2.205452187448366 0.0274223793847208 8.007281553398059 41.070388349514566 0.4631357965023841 0.5436738617035674 3.9292833147190622 4.174866644537295 0.8641260319009939 0.3280793744080287 0.1250660932411784 0.1242751530183465 0.0855446660478185 0.4110626308677901 +Tissue remodeling 2 12 2.2033252579559237 0.0275718319749382 3.66504854368932 16.594660194174757 -0.4917359988774192 0.4230166580965113 2.199832682863623 2.6500175179981453 1.1675597985012025 0.3259718546789134 0.0484634562358207 0.033549372412386 0.257178162993577 0.470104466443289 +Peptide catabolic process 3 10 2.1993271572217648 0.0278546680199702 3.871359223300971 10.351941747572816 1.5413280472635258 0.1625248535751528 1.454973091229298 0.9501768442987896 1.1353491763523988 0.2229381591694359 0.0001017478453213 0.0007914120786236 0.0010078083449561 0.0017902696143218 +Inorganic anion transport 5 15 2.190500545676046 0.0284879552689436 9.900485436893204 25.351941747572816 1.3590123122148194 0.2025490755989976 4.608697956226863 4.352203003870329 1.5972877171217004 0.2769639658120273 0.288471198078913 0.1468141932972727 0.026432780990415 0.0505496054928521 +Regulation of cell junction assembly 16 28 2.185233061960265 0.0288717625306007 9.259708737864075 32.94660194174757 -0.3358679076618157 0.5702437255549974 5.326525298900453 4.3036519947638725 0.8636914149992402 0.3111741135209888 0.4279811411777856 0.0993402801012091 0.5241295160507122 0.0492650030189575 +Ph reduction 4 8 2.1761063324154293 0.0295473105326911 4.422330097087379 12.509708737864075 1.1966830084586066 0.1930048880851129 1.91475781321527 1.7851607614701208 1.4167744165903868 0.2497649393583847 0.0082126449787597 0.002509898486982 0.0005176459432172 0.0019782028444853 +Phagocytosis 6 25 2.173298701723421 0.0297578431494165 8.633495145631068 38.567961165048544 0.0319038557979206 0.6898951952307567 4.3297508187988205 5.612290839266196 0.7929688055011034 0.2962152733283993 0.1106003446312499 0.1053672202985524 0.0234059346063466 0.1136383026224011 +Transmembrane transport 40 163 2.1681815187184803 0.0301448783926674 67.45631067961165 211.1359223300971 1.8122664376950308 0.3598356673827246 27.267027885156203 22.354947126810902 2.251277763144546 0.4188333713481413 0.0371764295831398 0.0103537497584547 0.0043807514098359 0.0007702311886519 +Regulation of monooxygenase activity 1 8 2.1660737516328723 0.0303055516187673 2.8932038834951457 9.66019417475728 0.7817888300341583 0.3389498053111844 1.538582258508953 1.1621322724229128 0.9599177691687591 0.2497120029370768 0.0076498462283805 0.0285062952815799 0.1401767104122509 0.3827254031641982 +Enzyme linked receptor protein signaling pathway 8 89 2.164278840598255 0.0304429556450325 25.24271844660194 117.68932038834951 0.1053848292396163 0.7149684279491084 9.284046259048107 15.168490031291515 0.7848849412953816 0.3313693252810506 0.1104759803742945 0.1385883555246223 0.7334260915713136 0.8497843347070557 +Defense response 27 170 2.1481875706690152 0.0316988577010277 39.067961165048544 208.97087378640776 0.011010237525631 0.8146618852499709 12.660052712295611 20.371289672620577 0.5963961283752253 0.287612323458898 0.0128782758518089 0.0042280424030864 0.0005381447009301 0.0008249988573623 +Oligosaccharide metabolic process 4 6 2.1407957114420206 0.0322905159644757 3.0606796116504853 6.179611650485437 -0.0148577354153068 0.2267163537664357 1.4017006052191363 1.1242135739548185 1.7186048285621385 0.2671195008920222 7.272754869097421e-08 2.400285967257217e-06 0.0001958127697586 0.0044081397545113 +Regulation of carbohydrate catabolic process 1 12 2.13658823279516 0.0326314975446835 3.1480582524271843 14.53883495145631 -0.025088322847414 0.5745798711188883 2.4917185391131262 1.460132525552545 0.8691706241229656 0.2899411078266523 0.0148056693212618 0.0532804729840314 0.2373655405257045 0.5602923701343501 +Regulation of hydrolase activity 18 138 2.1362110609382614 0.0326622142876777 34.9126213592233 168.98543689320388 0.0619050191092553 0.7830965788802455 11.250982089704202 16.868128778807822 0.6662391316189477 0.3027620005678602 0.0603570047931847 0.0544384557011827 0.0688836273059807 0.1851090195043139 +Vesicle mediated transport 53 252 2.135854069598506 0.0326913103435928 80.64805825242719 354.7718446601942 0.3002670711784583 0.7468304035232791 23.646053491950397 43.46537941024834 1.061791523718338 0.3560152131667141 0.0008896373387223 0.0088034825746065 0.0025544037213398 7.367676627920695e-05 +Vacuolar transport 10 32 2.1353360350861355 0.0327335714604306 12.599514563106796 48.657766990291265 0.2912214457519381 0.4804514439396684 5.627368951628201 8.33648332553773 1.2861810226472965 0.3567699710071671 0.0004962661475502 0.010432284093633 0.0175538492099469 0.0146317712625208 +Polysaccharide metabolic process 3 16 2.124743878216704 0.0336079900197692 4.905339805825243 19.468446601941743 -0.0296830415327655 0.5576011305266653 2.726758919472044 2.360984350121275 0.8873654575588947 0.2995415710151812 0.0369748680428621 0.1235163706059048 0.1927694592715518 0.1847572156688234 +Nucleotide transmembrane transport 4 9 2.123412937050754 0.0337192640589454 4.029126213592233 9.24271844660194 1.3657020532080593 0.1972377481261837 2.230443861436908 1.484326001257553 1.1744026177454787 0.2553979780962895 1.0 0.1459927402947744 0.0569248849368824 0.0007595134217252 +Glycoside metabolic process 3 8 2.11581697761178 0.0343603765872972 3.283980582524272 8.611650485436893 0.5062828222010527 0.3204164092287125 1.4990079825210394 0.6824144700308834 1.298018080705215 0.2868097664691992 0.0023758658868836 1.094486762177302e-05 0.0003832983840783 0.004988841333209 +Regulation of biological process involved in symbiotic interaction 2 8 2.1157823369101543 0.0343633240181424 2.3179611650485437 8.444174757281553 0.3422289691572587 0.5292477508521571 1.7867820286507592 1.14242547654536 0.8689534085392282 0.2992860869727938 0.1287528218161406 0.2414457297612108 0.0300655360870906 0.1546162324240269 +Cellular response to calcium ion 1 9 2.113687429130795 0.0345419728921241 3.412621359223301 11.436893203883496 -0.1296326915368724 0.6297164730901523 2.33371987785202 1.6155789062088 0.7313618074007439 0.2818464085852687 0.1828652209005429 0.0609936469852355 0.2646794233181401 0.6020019880837094 +Lipid storage 3 12 2.113607311994821 0.0345488208179562 4.543689320388349 16.905339805825243 0.2970217553985043 0.3661937485285719 2.202279044729986 2.0116820549871304 1.1851757279860726 0.2726034839593525 0.0024333620388206 0.0020253160845859 0.0448974549717978 0.0505698485029352 +Associative learning 2 10 2.1098663303170384 0.0348698711152906 3.2985436893203883 11.640776699029129 0.5833637693792252 0.3608696253992166 1.7586672512213413 1.9907766398439397 1.1416749351319833 0.2853176800833586 0.0007667347448651 0.0055856505984271 0.0121856638082503 0.1046016200934935 +Glycolipid catabolic process 5 6 2.1067603152887178 0.0351383610270803 3.6310679611650487 6.451456310679611 0.1059933679561382 0.1697430158083476 1.434595381284437 0.7664524352299261 1.9023109688101565 0.2365791262889882 1.7826192739143463e-09 6.740290595720374e-10 1.632317154479711e-07 9.46401314534944e-06 +Regulation of mononuclear cell migration 3 11 2.1003876543736646 0.0356947541363359 4.548543689320389 16.800970873786408 -0.0451470857329185 0.6235913245378032 2.5976226650972936 2.65933034660148 0.8401157368959713 0.2924888202464074 0.0012757726476668 0.009062215893767 0.0219504556074559 0.061872997913683 +Response to corticosteroid 4 25 2.096300072528972 0.0360555803248094 5.691747572815534 27.075242718446603 0.4079678667256687 0.5657392437937305 3.009633376757725 2.449820419279508 0.8211557550622286 0.3160966272616047 0.0584635742500571 0.0437228444640497 0.0457163514521504 0.0951908840010452 +Immune effector process 9 57 2.0952756105520773 0.0361464992620987 15.24757281553398 71.95145631067962 0.1132149302474773 0.7134571835986485 5.865968077599497 7.248540048217676 0.7436652301031837 0.3039621470392462 0.0328601744796203 0.0349265103090951 0.0827356382173843 0.1557520602216155 +Regulation of system process 5 47 2.0900463676213485 0.0366136347228205 12.432038834951456 59.63106796116505 0.142870153937744 0.6256858745623561 5.047131523930307 6.726256754497268 0.8769607822191469 0.3283787852153951 0.0862598446229127 0.0181868424946348 0.2650181824543516 0.2422036681666161 +Response to growth factor 10 76 2.085885176121901 0.0369890253924489 23.660194174757283 102.07038834951456 -0.1027882800096403 0.6500127575071359 9.638669486856536 13.591023481204804 0.8391550653072546 0.3197498193445682 0.0457005105145347 0.0985711836032471 0.3901388042645586 0.4023664604227183 +Nik nf kappab signaling 1 15 2.072411880696976 0.0382270463322258 4.138349514563107 19.54126213592233 0.0714124105738114 0.6513847930796516 2.965462225005852 3.0379071678395593 0.7482832286161373 0.2975891242666729 0.3058671484100957 0.163965403057363 0.5431129932756154 0.707910313539059 +Regulation of endothelial cell migration 4 22 2.071023586163424 0.0383565919457027 5.495145631067961 27.978155339805824 0.5955926179251096 0.4502618340992453 2.841693008322481 3.167187428757454 1.0132828172462562 0.3207559953771818 0.0139189683537814 0.080334798270157 0.1073694211549833 0.3895255812818475 +Regulation of peptidase activity 8 69 2.060799412572277 0.0393221805565808 17.567961165048544 78.76456310679612 0.2681055370567821 0.6519293611165848 6.220288033667961 7.048060158198876 0.8199709838080707 0.3419859398793775 0.0967862116473507 0.0226734228582852 0.0480950543500295 0.08186180833206 +Neuron projection organization 2 21 2.058192480743182 0.0395716601326812 6.37621359223301 22.95873786407767 0.1300948006112363 0.595353189317293 4.79246143792415 2.5705098204655825 0.8930737213838517 0.3150112992576556 0.046072228335376 0.0312241665816077 0.0915163649386154 0.0539169814954352 +Protein targeting to lysosome 1 8 2.0513083544642203 0.040236927403737 2.861650485436894 11.133495145631068 0.4665494631806399 0.3733123029661771 1.8767316131355816 1.7651272451933906 1.2080503341010538 0.3026029882111192 0.0046633751497463 0.0177148463510605 0.0920739634299925 0.0801939864225387 +Regulation of nitric oxide synthase activity 1 5 2.047947677029376 0.0405651265253848 1.8980582524271843 6.400485436893204 0.8861714382596724 0.3064882013314778 1.014121704509923 0.9815283096291466 0.998778670456744 0.2492245557560045 0.0038211367015083 0.0146091852998709 0.0773660358903978 0.2369865842622187 +Carbohydrate derivative catabolic process 11 31 2.04534310156765 0.04082104420897 9.92233009708738 34.20388349514563 -0.0123085756499559 0.2707665028006943 3.843893961107642 3.291233496452993 1.7787241070250257 0.2878972939517332 6.92488595932352e-08 1.2885834566861597e-08 2.0989589148160404e-05 0.0012798150482166 +Positive regulation of long term synaptic potentiation 2 5 2.043364835067337 0.0410163358091699 1.0946601941747574 3.1432038834951457 0.4266913694171521 0.4125553626995947 0.8292414542136507 1.102238422917561 1.2242523524253524 0.3132175218460173 0.0017760204843955 0.0002437892001771 0.0034327477034809 0.022960782690956 +Negative regulation of developmental growth 1 9 2.039634424793076 0.041386750666772 2.6067961165048543 10.118932038834952 0.4177621670448362 0.5151603515616955 2.0822300468824904 1.7258544598953018 0.8590834947670382 0.302034516552393 0.2336798458054532 0.0981876870196897 0.3814690602891797 0.495315005727891 +Chemical synaptic transmission postsynaptic 2 10 2.031520983622942 0.0422021731341049 2.4733009708737863 11.111650485436892 0.5657463373755282 0.4860434502535432 1.819998340098205 2.2081403224579756 0.8629150008491288 0.311233189592999 0.1583124314184509 0.0459506122728715 0.0530915597366878 0.2431148013647541 +Regulation of postsynaptic membrane potential 2 10 2.031520983622942 0.0422021731341049 2.4733009708737863 11.111650485436892 0.5657463373755282 0.4860434502535432 1.819998340098205 2.2081403224579756 0.8629150008491288 0.311233189592999 0.1624541869963563 0.0483495219963649 0.0569111676931314 0.2564137422230053 +Protein localization to lysosome 1 11 2.0270545273242675 0.0426568365685364 3.5364077669902914 14.37621359223301 0.6191344010889903 0.3619681772746835 2.0811532251007954 2.18038858944462 1.1869570048706093 0.3022181269423334 0.0140700862732742 0.0507931717892238 0.2282899009392132 0.1046016200934935 +Regulation of nik nf kappab signaling 1 14 2.025104643677772 0.0428566201877962 3.1650485436893203 15.317961165048544 0.1921664077218407 0.6080731107616629 2.6707589095579776 1.8350333238017016 0.7973348396755618 0.294963561671023 0.2336798458054532 0.0981876870196897 0.3814690602891797 0.495315005727891 +Diol metabolic process 2 5 2.0244500736336417 0.0429238640419025 2.5315533980582523 7.747572815533981 0.934609081792458 0.2730932800244148 1.324333323602112 0.9054146354978068 1.183401939154622 0.2688651038177358 1.0 0.0004672463302539 0.0063676045893722 0.0403506671570748 +Diol biosynthetic process 2 5 2.0244500736336417 0.0429238640419025 2.5315533980582523 7.747572815533981 0.934609081792458 0.2730932800244148 1.324333323602112 0.9054146354978068 1.183401939154622 0.2688651038177358 1.0 0.0002437892001771 0.0034327477034809 0.022960782690956 +Glycosylation 5 30 2.021896278045747 0.0431870683679143 13.33495145631068 45.42718446601942 0.831363055351092 0.4028474919440285 5.5712021107485015 7.578523489860055 1.3433056638769032 0.3649215649501745 0.0448222654886068 0.0747845759902132 0.2047192015266442 0.6837145481346036 +Response to amyloid beta 1 6 2.0198281531984743 0.0434012158089331 1.8713592233009708 5.91747572815534 0.2206633711995859 0.4678383207618323 1.2867717931543454 1.328545973894273 1.1144604515178314 0.3257294628423651 0.0055832614279084 0.0210734332562196 0.1075130907868997 0.3106281566010752 +Cellular response to amyloid beta 1 6 2.0198281531984743 0.0434012158089331 1.8713592233009708 5.91747572815534 0.2206633711995859 0.4678383207618323 1.2867717931543454 1.328545973894273 1.1144604515178314 0.3257294628423651 0.0055832614279084 0.0210734332562196 0.1075130907868997 0.3106281566010752 +Learning 2 17 2.0131156305751423 0.04410246623719 4.589805825242719 18.93446601941747 0.4051379104506336 0.500788863717711 2.588096905713564 2.8673042134954594 0.95936751956091 0.3128033021759736 0.0044455523824174 0.0289872856979344 0.0249977551762954 0.2376530168808469 +Liposaccharide metabolic process 6 12 2.0073490849229296 0.0447125060983466 7.393203883495145 16.839805825242717 0.7162233803449398 0.1804705798886219 2.8837934205508033 2.921890590438037 1.8930166841377585 0.2403675114219934 3.40386716131938e-07 1.410362515489926e-06 0.0004948612164357 0.0221489740322384 +Sterol transport 5 17 2.0067163118550675 0.0447798781607073 5.516990291262136 23.23058252427185 0.3564989162781894 0.4550431454343515 2.7566693478017315 3.339632072416373 1.1016145306573315 0.3225081354886266 0.0044455523824174 0.0043894701524644 0.0061759775127424 0.0473183813132007 +Regulation of leukocyte chemotaxis 2 9 2.0035643285012728 0.0451167502211804 4.288834951456311 15.735436893203884 0.121603520762296 0.6602233173792045 2.8123464966854943 2.274896040172022 0.7256331739166136 0.2891116210268169 0.0148056693212618 0.0532804729840314 0.0649283885443843 0.1126513905607482 +Negative regulation of nervous system development 2 13 1.995159793341285 0.0460254546524032 4.225728155339806 17.99514563106796 0.4680685636974716 0.419713233745777 2.1977522064718618 2.960086545598349 1.0442754970945465 0.2873726818408866 0.3194831905047319 0.1779321056766125 0.2971320950388168 0.5332612412749236 +Regulation of nervous system process 4 8 1.9951185959584017 0.0460299466305711 2.6941747572815533 11.186893203883496 0.709685710886722 0.4267375683332639 1.6891041598029932 2.2483053074671338 0.9287991925104498 0.3050882814355576 0.2260688267312995 0.0142951840993497 0.0376866621833409 0.1086169414893013 +Negative regulation of cell growth 2 22 1.9940085070832387 0.0461511248413675 5.313106796116505 27.703883495145632 0.2289377296643748 0.6330110471704592 3.257779793474284 3.491971994963746 0.7516898890795832 0.3034030974476691 0.0920994578831573 0.0821570360679712 0.4687371049865676 0.398355531742245 +Mucopolysaccharide metabolic process 3 7 1.99043146143972 0.046543427055357 3.400485436893204 8.912621359223301 0.5894446998893683 0.2689339883290864 1.6227448151896249 1.7256308603927724 1.433353391777711 0.275728271795533 0.0013622028220488 0.0096414106757913 0.0045948289685349 0.066946879618907 +Regulation of jnk cascade 0 10 1.9844609441168504 0.0472044778491669 3.745145631067961 12.730582524271844 0.0342722637181126 0.5856074037040684 2.335999552831812 2.800439745372428 0.865405433051665 0.3027772361459041 0.3361355940595682 0.5601787468810149 0.872613984533778 0.7781742569431336 +Regulation of leukocyte migration 3 17 1.9831841978233904 0.0473468583436442 6.080097087378641 26.6504854368932 0.4712165673240142 0.5560717407414059 2.980664549328318 3.842679935245632 0.8934424673809059 0.3310773445531978 0.0054233896663051 0.0347449548593629 0.0326937613140359 0.1454895561901762 +Metal ion homeostasis 19 63 1.980453193472924 0.0476526278590188 22.37864077669903 79.5 0.7762327689006491 0.4501210966631583 8.485414676383348 8.298876985671072 1.3957415688189287 0.3857448193070677 0.0394703529271656 0.2578342108456208 0.0278713229023745 0.0096307398581357 +Biological adhesion 12 119 1.975652726215113 0.0481941225302522 36.79854368932039 169.14320388349515 -0.0786074092810717 0.7268401382457587 13.443000770803348 22.05897605707452 0.7413278367584214 0.3123990966272218 0.4254629522107154 0.3440522736768548 0.776932713748443 0.7959303920494948 +Neuron maturation 1 5 1.970132667902157 0.0488231678003177 1.6966019417475728 5.737864077669903 0.3884050692002241 0.3270287101850628 1.1310653568868725 1.188220216330287 1.2760249805885358 0.2674215567147113 0.0065792573185243 0.0246740936940832 0.123579290468326 0.3470060894740981 +Homeostatic process 35 227 1.9622352506162213 0.0497351016673932 61.157766990291265 292.84223300970876 0.0447704154292028 0.710284107974066 17.297703502776844 27.83231450914562 0.9738999187508842 0.3562778454735766 0.0003830002272628 0.000560541559542 0.0009576953458588 7.061704638185019e-05 +Chloride transport 4 7 1.961928033699184 0.0497708634765821 4.33252427184466 12.12621359223301 1.0302584084066435 0.2341882174183942 2.3624510960969567 2.26059366569241 1.2797232968088257 0.2563105728143979 0.1499686155438198 0.0412914524019695 0.0011317572349641 0.0208457080812305 diff --git a/msigdb_gobp/metrics.json b/msigdb_gobp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..ffe28fefef073718584cbeac0fca90503b35cfcb --- /dev/null +++ b/msigdb_gobp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2453, + "annotations_size": 6157, + "title": "Average number of proteins per term", + "value": 15.796491797953548 +} \ No newline at end of file diff --git a/msigdb_gobp/paths.json b/msigdb_gobp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..7f8e72181310b8a05c54d001f601e3d9bc837f2e --- /dev/null +++ b/msigdb_gobp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gobp/fragment/C334/C334_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gobp/result.tsv b/msigdb_gobp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..7c80fa61617ad0b6def277bbcb723946d386e5d0 --- /dev/null +++ b/msigdb_gobp/result.tsv @@ -0,0 +1,1744 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Carbohydrate catabolic process 0.7346246103402998 3.292798959570481 0.0009919537609757 0.9977805380328784 0.0140724868809389 44 P05067,Q99519,P07686,P10253,P17900,Q14108,P16278 7 +Entry into host 0.8236186537478261 3.1744021560797573 0.0015014550248322 0.9999040233487212 0.0185631698552049 27 P11279,Q8WTV0,Q92692,P08195,P02786,O15118,Q9BTY2,Q9Y624,Q12899,Q14108,P35613 11 +Steroid metabolic process 0.6889139900931414 3.141821042908403 0.0016790062418368 0.9999678895693946 0.020349687856278 52 P05067,Q8WTV0,Q9UBM7,Q9BQE5,Q99538,P61916,Q14849,O15118,Q15392,P04062,P38571,Q14739,Q13510 13 +Behavior 0.6534033249660077 3.140646650812575 0.001685752851078 0.9999691982334667 0.0203913169039052 62 P05067,P07686,Q99538,O15118,P10253,P17900,P04062,P50897,P54802,P51790,Q92542 11 +Carbohydrate metabolic process 0.5353426867999489 3.135773974232939 0.0017140124755514 0.9999741248962424 0.0204188950660227 112 P05067,P06865,Q99519,P06280,P07686,P08195,Q9BTY2,P10253,P17900,O43505,P08236,Q14108,P16278 13 +Biological process involved in symbiotic interaction 0.6364260769569349 3.0715170675849865 0.0021297398800153 0.999998008837132 0.0240601989747783 64 Q13547,P11279,Q8WTV0,Q06787,Q92692,P08195,Q9Y3E7,P02786,O15118,Q9BTY2,Q9Y624,Q13573,Q12899,P11717,Q14108,P35613,P05556 17 +Biological process involved in interaction with host 0.6998379786080542 3.065965501595898 0.0021696834715656 0.9999984437854416 0.0244665588542669 44 P11279,Q8WTV0,P08195,P02786,O15118,Q9BTY2,Q9Y624,Q12899,Q14108,P35613 10 +Chemical homeostasis 0.5349242776788117 3.0413496890904894 0.0023552012573266 0.9999995046876964 0.0255895628028423 133 P05067,O75503,Q9UHB6,P61916,P02786,P50897,Q93050,P13693,Q06481,Q658P3,Q8WTV0,Q15904,P07686,Q9Y487,O15118,P51790,Q5BJF2,P30519,P55011,Q96AX1,Q9ULM6,P04062,P42785 23 +Endocytosis 0.5916108202014784 3.0187059092996447 0.0025385682660781 0.999999840279004 0.027135355580283 84 P05067,Q08380,Q8WTV0,Q99523,P02786,O15118,P50897,P11717,Q14108,Q06481 10 +Sphingolipid metabolic process 0.8327169581055787 3.010239439248521 0.0026104181495443 0.9999998974954752 0.0278550165454842 22 P06865,Q99519,P06280,P07686,P17900,P04062,P50897,O43464,O15269,P16278,Q13510 11 +Cellular ion homeostasis 0.6142341604959898 2.99292440437654 0.0027631818297217 0.9999999600828108 0.0286412635111062 67 P55011,P05067,Q96AX1,Q9ULM6,Q9HD20,Q15904,O75503,P07686,Q9Y487,P02786,P50897,P51790,Q93050,P13693 14 +Sterol metabolic process 0.7664575594223826 2.928601472216193 0.0034049067396837 0.9999999992415788 0.0345370853315202 29 P05067,Q8WTV0,Q9UBM7,Q9BQE5,P61916,Q14849,O15118,Q15392,P04062,P38571,Q14739 11 +Vacuole organization 0.7195387173674096 2.9249698395774804 0.0034448960931858 0.9999999994076024 0.0348852388910287 36 Q96AX1,Q5MNZ6,O75503,P11117,P07686,O14773,P10253,P04062,P50897,P54802,Q14108 11 +Viral process 0.5154387845167586 2.9215005634286326 0.0034834964553212 0.9999999995332988 0.0351029258190059 112 Q10472,Q92692,Q02880,P02786,Q9ULC4,Q13573,P11717,Q14108,Q13547,P11279,Q8WTV0,Q06787,O15118,P05556,Q9Y624,P08195,Q9Y3E7,Q12899,P35613,Q99873 20 +Lytic vacuole organization 0.8618750888122152 2.8802149366505967 0.0039740414554478 0.9999999999774868 0.0390865387239499 18 O75503,P11117,P07686,O14773,P10253,P54802,P50897,Q14108 8 +Ion homeostasis 0.5827846795720196 2.858845313669598 0.0042518606229304 0.999999999995959 0.0406501643717127 78 P55011,P05067,P30519,Q96AX1,Q9ULM6,Q15904,Q9HD20,O75503,P07686,Q9Y487,P02786,P50897,P51790,Q93050,P13693,Q658P3 16 +Locomotory behavior 0.7659640125942901 2.842451289552831 0.004476807155781 0.9999999999989946 0.0424710349123941 26 P05067,P07686,O15118,P10253,P50897,P54802,P51790 7 +Neuron death 0.6070388585956304 2.783503492254526 0.005377528356135 0.9999999999999962 0.0487620649318459 62 P05067,Q99538,P49427,Q15392,Q15375,P50897,P04062,Q92542,Q01105,O43464,O95831 11 +Inflammatory response 0.6423866266724249 2.7743845965882072 0.0055306252362861 0.9999999999999986 0.0498496912480371 50 P05067,Q9ULM6,P60900,Q9BQE5,Q8IV08,P02786,Q9Y624,P42785,P04062,Q9Y263,P05556,P38571,Q06481 13 +Receptor mediated endocytosis 0.6601840101075509 2.7596725454201065 0.0057859323952198 0.9999999999999996 0.0514797482042899 41 P05067,P11717,P50897,P02786 4 +Adult behavior 0.8502704309576138 2.7586095323216657 0.0058047848290823 0.9999999999999998 0.0515729584309665 17 P05067,O15118,P50897,P51790,Q92542 5 +Nervous system process 0.5675493319646007 2.7492774052651563 0.005972681455775 1.0 0.0527601143804974 80 P05067,P07686,Q9UQB8,Q99538,O14773,P10253,P17900,P50897,Q92542,Q14108 10 +Lipid localization 0.6276583165724046 2.746410067245084 0.0060251402322499 1.0 0.0531472613323254 54 Q9H4M9,Q9UHB6,P61916,P17900,P31751,O15439,Q14108,Q8WTV0,Q9UID3,P07686,O15118,P35790,O43772,Q86Y82,Q14849,P04062,Q9BQE5,P08183,O43808 19 +Protein processing 0.6657393281125608 2.73116993021357 0.0063109921914414 1.0 0.055194288242479 39 O75503,Q99538,Q15392,P42892,O75976,Q92542,Q92896 7 +Neuromuscular process 0.785826053345382 2.7213506994786023 0.006501574639373 1.0 0.0561433310723982 21 P05067,P07686,O14773,P10253,P17900 5 +Lysosomal lumen acidification 0.9922480620155044 2.6902616337777023 0.0071396019838019 1.0 0.0602171635811896 2 O75503 1 +Secondary alcohol metabolic process 0.7006763474189054 2.6861617039128767 0.0072278099401064 1.0 0.060628917985334 33 P05067,Q8WTV0,Q9UBM7,Q9BQE5,P61916,Q14849,O15118,Q15392,P04062,Q14739 10 +Neuron apoptotic process 0.6365824317739099 2.651822246575435 0.008005867673003 1.0 0.0657213332346742 45 P05067,Q99538,P49427,Q15375,P50897,P04062,Q92542,Q01105 8 +Aminoglycan metabolic process 0.9062865248282644 2.646393814901985 0.0081355042406408 1.0 0.0664327581029514 12 P06865,P07686,P54802,O43505,P08236,P16278,P15586 7 +Cellular monovalent inorganic cation homeostasis 0.823079248645744 2.6351121330657516 0.0084109491944612 1.0 0.0685910121725802 17 P55011,Q96AX1,P61421,P05026,Q15904,O75503,Q9Y487,P50897,P51790,Q93050 10 +Cellular homeostasis 0.4984290008189007 2.6159212041050792 0.00889870905124 1.0 0.0716513358839806 107 P55011,P05067,Q96AX1,Q9ULM6,Q15904,O75503,P07686,Q9Y487,P02786,P10253,P50897,P51790,Q16763,Q93050,P13693,Q9Y263 16 +Ceramide metabolic process 0.8631361428274043 2.600769697336602 0.0093014874072976 1.0 0.0740896951322489 14 P06865,Q99519,P06280,P07686,P17900,P04062,O43464,O15269,Q13510 9 +Adult locomotory behavior 0.862882509304626 2.5996889721560223 0.0093308288278768 1.0 0.0742246939189117 14 P05067,P50897,P51790,O15118 4 +Microglia differentiation 0.9665442676458602 2.585044468046118 0.009736643894564 1.0 0.0756035386171306 2 P05067 1 +Glycosylceramide catabolic process 0.96654426764586 2.585044468046118 0.009736643894564 1.0 0.0756035386171306 2 P06280 1 +Glycosylceramide metabolic process 0.96654426764586 2.585044468046118 0.009736643894564 1.0 0.0756035386171306 2 P06280 1 +Anatomical structure homeostasis 0.6998358874762792 2.581414869473064 0.0098396255979913 1.0 0.0756035386171306 30 O14773,P02786,Q9Y624,P10253,P51790,P38571,P05556 7 +Membrane lipid catabolic process 0.9043145415224068 2.577554654948188 0.0099502144596566 1.0 0.0756035386171306 11 P06865,Q99519,P06280,P07686,P17900,P50897,Q13510 7 +Cognition 0.7022899492555705 2.5669720607045003 0.0102590878158874 1.0 0.0768433134822617 29 P05067,P17900,Q99538,P50897 4 +Neuron projection guidance 0.808058341435669 2.566051812297245 0.0102863461885034 1.0 0.0768758443849931 17 P05067,P42892,Q15375,O94813 4 +Negative regulation of developmental process 0.5495145625491201 2.56566836369943 0.0102977232054535 1.0 0.0768758443849931 78 P05067,O75179,Q96G23,Q99538,Q99523,P02786,Q15375,Q92688,P05556,P13693,Q06481,Q99873 12 +Viral life cycle 0.5506517733220334 2.565561742176779 0.0103008886824134 1.0 0.0768758443849931 77 P11279,Q8WTV0,Q06787,P08195,Q92692,Q9Y3E7,Q02880,P02786,O15118,Q9Y624,Q12899,Q14108,P35613,P05556 14 +Acute phase response 0.9592003263973904 2.5547632956031587 0.010626003088541 1.0 0.0778860726382701 2 P02786 1 +Regulation of mda 5 signaling pathway 0.9583843329253368 2.5513927066161632 0.0107293354291022 1.0 0.0781781280911037 2 O75179 1 +Humoral immune response mediated by circulating immunoglobulin 0.9583843329253372 2.5513927066161632 0.0107293354291022 1.0 0.0781781280911037 2 Q9UQ84 1 +Mda 5 signaling pathway 0.9583843329253368 2.5513927066161632 0.0107293354291022 1.0 0.0781781280911037 2 O75179 1 +Neuromuscular process controlling balance 0.8974969686873641 2.5504120084027284 0.0107595680719592 1.0 0.078305745412592 11 P05067,P07686,P17900,P10253 4 +Monovalent inorganic cation homeostasis 0.7906666237802713 2.549658522356307 0.0107828477164033 1.0 0.0783194097621969 18 P55011,Q96AX1,P61421,P05026,Q15904,O75503,Q9Y487,P50897,P51790,Q93050 10 +Leucine transport 0.957160342717259 2.5463345680371887 0.0108860796657428 1.0 0.078853638237622 2 Q9H2J7 1 +Branched chain amino acid transport 0.957160342717259 2.5463345680371887 0.0108860796657428 1.0 0.078853638237622 2 Q9H2J7 1 +Membrane lipid metabolic process 0.7011983261319273 2.534196995066593 0.0112705351948192 1.0 0.0807634259759125 28 P06865,Q99519,P06280,P07686,P17900,P04062,P50897,O15269,P16278,Q13510 10 +Long term synaptic potentiation 0.9181811490561615 2.518954721889342 0.0117703791465706 1.0 0.0832991085119947 9 P05067,Q99538,Q92542 3 +Circulatory system process 0.5847908058331386 2.5086499011741 0.0121193534348067 1.0 0.0851969938076278 58 P55011,Q9HB40,P05026,Q9UIQ6,Q12802,O75844,O94813,Q14126,Q9UDY2,P02786,Q6P179,P42785,P10253,P42892,P08183,O15439,P20020,O60568 18 +Positive regulation of synaptic transmission 0.7953294961212471 2.5070557834766083 0.0121741496958494 1.0 0.0854689163937796 17 P05067,Q99538,Q92542 3 +Taxis 0.6095840514305984 2.5049118834474333 0.0122481903308904 1.0 0.0858803188130927 48 P55011,P05067,Q07021,P11233,O94813,Q99538,P42892,Q15375,P35613 9 +Positive regulation of rig i signaling pathway 0.9436964504283972 2.490516522068801 0.0127557564906273 1.0 0.0877510533103826 2 O75179 1 +Negative regulation of growth 0.7086802475630445 2.4896567576139192 0.0127866517122725 1.0 0.0878654180719443 24 O94813,Q99538,P50897 3 +Neuron development 0.4878762666933754 2.488926914215578 0.0128129302310475 1.0 0.0879478388322852 139 P05067,Q9H4M9,O75503,Q02880,P42892,P50897,Q14108,Q9Y263,Q06481,Q06787,O94813,Q96G23,Q96HC4,Q15375,P54802,Q66K74,P05556,Q9UQB8,P04062,Q15334,P84095,O60701,O43464,P35613,Q99873 25 +Replication fork protection 0.9396164830681364 2.4735374017151024 0.0133782799836779 1.0 0.0910166517784584 2 Q9UNS1 1 +Organophosphate ester transport 0.732536810280839 2.4513756224118195 0.0142311359363447 1.0 0.0951369206949777 21 Q8WTV0,Q9BSK2,Q9H2D1,P61916,P08183,O15439,O43808,Q14108 8 +Myeloid leukocyte differentiation 0.7216771850974251 2.445973483774054 0.0144461624601364 1.0 0.0964696553872667 22 P05067,P04062,Q15904,P02786 4 +Regulation of ph 0.856906412820686 2.4446874421884703 0.0144977723178578 1.0 0.0965003072011361 12 Q15904,O75503,Q9Y487,P50897,P51790,Q93050 6 +Regulation of cellular ph 0.856906412820686 2.4446874421884703 0.0144977723178578 1.0 0.0965003072011361 12 Q15904,O75503,Q9Y487,P50897,P51790,Q93050 6 +Axon development 0.5631527107556332 2.43228322806072 0.0150039696284756 1.0 0.0993327322607788 62 P05067,O94813,Q96G23,Q9UQB8,P84095,P42892,Q15375,P05556,Q66K74,Q15334,P35613,Q06481 12 +Protein maturation 0.5719295326669502 2.4301853650827474 0.0150911024746478 1.0 0.0998022749048408 59 Q9NRN7,O75503,Q99538,Q15392,Q10471,P42892,O75976,Q92542,Q92896,Q86UY6,O43464,O00170 12 +Protein o linked glycosylation via threonine 0.9273765809873532 2.422420260872322 0.0154175089334804 1.0 0.1009349140041912 2 Q10472 1 +Cellular response to inorganic substance 0.671416177087881 2.414175562280975 0.0157708612637526 1.0 0.1025241034642264 30 P55011,P05067,Q99538,P54132,Q92542,Q9UNS1,O95831 7 +Positive regulation of response to external stimulus 0.6064078874779089 2.413831794971892 0.0157857479428433 1.0 0.1025241034642264 43 P05067,O75179,P11279,Q9ULM6,Q07021,O94813,Q92692,Q9NUD5,Q99538 9 +Cellular response to low density lipoprotein particle stimulus 0.9232966136270936 2.4053214150973834 0.016158247296349 1.0 0.1039564562211298 2 O15118 1 +Angiogenesis involved in wound healing 0.9220726234190142 2.400185943903997 0.0163867454544868 1.0 0.1052066650294841 2 P42785 1 +Regulation of appetite 0.9171766625867004 2.3796172504693978 0.0173306285707652 1.0 0.1092166633676579 2 Q9UMX5 1 +Negative regulation of response to food 0.9171766625867004 2.3796172504693978 0.0173306285707652 1.0 0.1092166633676579 2 Q9UMX5 1 +Regulation of response to food 0.9171766625867004 2.3796172504693978 0.0173306285707652 1.0 0.1092166633676579 2 Q9UMX5 1 +Positive regulation of mast cell activation 0.9167686658506746 2.3779012585522996 0.0174114876593947 1.0 0.1095410475852346 2 Q92692 1 +Vascular process in circulatory system 0.6836680200755445 2.369255222175204 0.0178239490165017 1.0 0.11141325288792 25 P55011,Q9HB40,O94813,P02786,P42892,P08183,O15439,P20020,O60568 9 +Lipid homeostasis 0.7497484591391615 2.353313092599078 0.0186069595963307 1.0 0.1142849793286605 18 Q8WTV0,Q9H4M9,Q9UHB6,P61916,O15118,Q9Y6C9,Q5BJF2 7 +Regulation of response to external stimulus 0.5008826485463329 2.353102893582156 0.0186174816090054 1.0 0.1142849793286605 95 P05067,Q92692,Q9NUD5,Q99538,Q9UMX5,Q06481,P11279,P60900,O94813,Q96G23,O43657,P55011,Q9ULM6,Q7Z739,P80303,P51809,P04062,O75179,Q07021 19 +Positive regulation of excitatory postsynaptic potential 0.910240718074258 2.350405004783077 0.0187529937885924 1.0 0.1144463265007309 2 Q9UQB8 1 +Protein k6 linked ubiquitination 0.9094247246022042 2.3469626362145943 0.0189271526856034 1.0 0.1153806723616437 2 Q16763 1 +Mononuclear cell migration 0.7479802648568377 2.344720323449487 0.0190413567130374 1.0 0.1156498003996277 18 P05067,O94813,Q99538,Q9Y624,P04062 5 +Phosphatidylethanolamine metabolic process 0.9086087311301536 2.3435190836452153 0.0191027849612508 1.0 0.1156498003996277 2 P35790 1 +Phosphatidylethanolamine biosynthetic process 0.9086087311301536 2.3435190836452153 0.0191027849612508 1.0 0.1156498003996277 2 P35790 1 +Lysosomal transport 0.6633066292606024 2.339387694558563 0.0193153778079295 1.0 0.1163330192407871 29 Q96AX1,P11279,Q9UID3,Q9Y3E7,Q99523,P51809,O15118,P11717,Q14108 9 +Protein containing complex remodeling 0.9061607507139974 2.33318132820577 0.0196386303943203 1.0 0.1169853006170111 2 Q8WTV0 1 +Regulation of synapse structure or activity 0.6629116247917001 2.3127486478523265 0.020736462637825 1.0 0.1213347509653417 28 P05067,Q15375,P50897 3 +Leukocyte migration 0.63882654309272 2.3066323496112013 0.0210753245324248 1.0 0.1213347509653417 33 P55011,P05067,Q07021,O94813,Q99538,Q9Y624,P04062,P35613,P05556 9 +Cell maturation 0.7260727263916591 2.3016149763920524 0.0213568948049893 1.0 0.1213347509653417 19 P05067,O75503 2 +Glycosphingolipid metabolic process 0.96852003270646 2.301229258553688 0.0213786759111922 1.0 0.1213347509653417 7 P06865,Q99519,P06280,P07686,P17900,P16278 6 +Ceramide catabolic process 0.9685200327064604 2.301229258553688 0.0213786759111922 1.0 0.1213347509653417 7 P06865,Q99519,P06280,P07686,P17900,Q13510 6 +Sterol homeostasis 0.8617222998930099 2.298428280046711 0.021537425487258 1.0 0.1213347509653417 9 Q8WTV0,Q9H4M9,Q9UHB6,P61916,O15118,Q5BJF2 6 +Cell recognition 0.7249917348909238 2.2961962584431657 0.0216646623876883 1.0 0.1213347509653417 19 P05067,Q8WTV0 2 +Striated muscle cell differentiation 0.6188530057055728 2.286656437252701 0.0222158842780857 1.0 0.1213347509653417 36 Q13547,Q9NYL9,Q13045,Q9H4M9,Q12802,O75844,Q8IV08,Q99523,Q96HC4,P58546,P42345,Q9H7B4,Q16527,P05556 14 +Multi multicellular organism process 0.7093951647115565 2.2854734947244664 0.022285078866733 1.0 0.1213347509653417 20 Q9BQE5,Q9UIQ6,Q07021,P07686,P35613 5 +Positive regulation of cholesterol storage 0.8935128518971885 2.2796006284392383 0.0226313856594448 1.0 0.1222293346536861 2 Q8WTV0 1 +Cholesterol storage 0.8935128518971885 2.2796006284392383 0.0226313856594448 1.0 0.1222293346536861 2 Q8WTV0 1 +Regulation of blood pressure 0.7686499831573322 2.253218477993673 0.0242453768879007 1.0 0.1287508290094932 15 Q9HB40,P42892,Q9UIQ6 3 +Cellular carbohydrate catabolic process 0.7509736994260315 2.241438953180082 0.0249976556918636 1.0 0.1318856607496181 16 P10253,Q14108 2 +Prenylation 0.8833129334965333 2.2361855870368887 0.0253396169296966 1.0 0.133575360818615 2 Q92696 1 +Negative regulation of neuron apoptotic process 0.6815138900980628 2.231818993236234 0.0256269284992785 1.0 0.1349743359880733 22 P04062,Q99538,P50897 3 +Phospholipid transport 0.8446214788194527 2.230430621821129 0.025718868546948 1.0 0.1352272191661478 9 Q14108,P61916 2 +Regulation of transmission of nerve impulse 0.8800489596083266 2.222254475047311 0.0262661128687948 1.0 0.1376344314324851 2 P04062 1 +Regulation of neuronal action potential 0.8800489596083266 2.222254475047311 0.0262661128687948 1.0 0.1376344314324851 2 P04062 1 +Transition metal ion homeostasis 0.709925378432068 2.22030302153041 0.0263982049679234 1.0 0.1380915445943115 19 P05067,Q15904,Q9Y487,P02786,Q658P3 5 +Cellular transition metal ion homeostasis 0.7598857538097266 2.2131069808871446 0.0268902709432461 1.0 0.1398339511803771 15 P05067,P02786 2 +Proteolysis 0.4159305478360187 2.211052031862209 0.0270322341309343 1.0 0.1404535574212345 323 P05067,Q9HB40,Q9UIQ6,O75503,Q8IXB1,Q99538,P02786,Q8TBC4,P42892,O75976,P55786,Q9H3G5,Q06481,Q9Y263,P10619,O14773,Q92820,Q15375,Q92542,Q92896,Q13501,P49721,Q15392,P04062,P28072,P49427,P42785,Q92688,O43464,O95831 30 +Regulation of long term synaptic potentiation 0.94240490982541 2.2062304316775636 0.0273678695468038 1.0 0.1416283242641627 7 P05067,Q99538,Q92542 3 +Negative regulation of neuron death 0.6176329786088599 2.205452187448366 0.0274223793847208 1.0 0.1416283242641627 34 Q99538,Q01105,P04062,P50897,O43464 5 +Tissue remodeling 0.7994391561403021 2.2033252579559233 0.0275718319749382 1.0 0.14181429785556 12 O14773,P02786 2 +Positive regulation of potassium ion import across plasma membrane 0.8755609955120367 2.203069076606237 0.0275898803448271 1.0 0.14181429785556 2 P05026 1 +Regulation of potassium ion import 0.8755609955120367 2.203069076606237 0.0275898803448271 1.0 0.14181429785556 2 P05026 1 +Keratan sulfate metabolic process 0.9881632653061224 2.2026985057870605 0.0276160056591572 1.0 0.14181429785556 3 P16278,O43505 2 +Peptide catabolic process 0.8241959567587069 2.1993271572217648 0.0278546680199702 1.0 0.1429176591657975 10 O14773,P42892,Q9UIQ6 3 +Sterol import 0.87352101183191 2.1943369575594076 0.0282111944139351 1.0 0.1445060931835264 2 Q8WTV0 1 +Response to hepatocyte growth factor 0.9849297895918936 2.1906557892838654 0.0284767106708514 1.0 0.1453192548391765 3 Q99538 1 +Inorganic anion transport 0.7549648778552412 2.190500545676046 0.0284879552689436 1.0 0.1453192548391765 15 P55011,Q9UHG3,Q9C0H2,P08183,P51790 5 +Oligosaccharide catabolic process 0.9836734693877552 2.185972944568903 0.0288175847958438 1.0 0.146849961528035 3 P17900,Q99519 2 +Regulation of cell junction assembly 0.6413100307734673 2.185233061960265 0.0288717625306007 1.0 0.1469119354552965 28 Q04637,P05067,Q07157,Q9H2P0,O75955,Q7Z460,Q96HC4,Q9Y624,Q9NUL3,Q9H2G2,Q15375,P60903,O75116,Q96AC1,P17612,P63167 16 +Positive regulation of pinocytosis 0.9827339792390892 2.182469666347825 0.029074887611868 1.0 0.1473366938487832 3 P50897 1 +Regulation of pinocytosis 0.9827339792390892 2.182469666347825 0.029074887611868 1.0 0.1473366938487832 3 P50897 1 +Regulation of anion channel activity 0.869849041207672 2.1786011360517 0.0293613117223467 1.0 0.148299914909343 2 P08183 1 +Ph reduction 0.8819386763907409 2.1761063324154293 0.0295473105326911 1.0 0.149117041762114 8 Q93050,P50897,P51790,O75503 4 +Ganglioside metabolic process 0.984075132707227 2.1740933379332943 0.0296981261955568 1.0 0.1496328666006905 4 P06865,P17900,Q99519 3 +Ganglioside catabolic process 0.984075132707227 2.1740933379332943 0.0296981261955568 1.0 0.1496328666006905 4 P06865,P17900,Q99519 3 +Phagocytosis 0.649164602918472 2.1732987017234215 0.0297578431494165 1.0 0.1496638348187357 25 Q8WTV0,P51809,P51790,P05556,Q06481,Q12907 6 +Cellular response to insulin like growth factor stimulus 0.8682170542635674 2.171600030723365 0.0298858447066563 1.0 0.1499650740496194 2 Q9BSK2 1 +Transmembrane transport 0.4671169043311051 2.1681815187184803 0.0301448783926674 1.0 0.151018727635194 163 P05067,Q9BSK2,Q9C0H2,Q13423,P31751,O15439,Q8IXU6,O60830,Q8TB61,Q06481,P61421,Q8WTV0,P05026,Q06787,Q99523,P54709,O96008,P51790,Q9H2J7,Q9NS69,P05556,P55011,Q9Y4C2,O43772,Q9HD20,Q99595,O75844,Q9UHG3,O14925,Q9UM00,P04062,Q03519,Q9H2D1,Q15334,P08195,Q93034,Q8N4V1,P08183,O43808,O95831 40 +Pinocytosis 0.9821364355813358 2.1670109905766473 0.0302340160981098 1.0 0.1513421439967985 4 P50897 1 +Regulation of monooxygenase activity 0.8793259377936048 2.1660737516328723 0.0303055516187673 1.0 0.1515769953832255 8 P06280 1 +Enzyme linked receptor protein signaling pathway 0.4922132696956395 2.164278840598255 0.0304429556450325 1.0 0.1521406476513516 89 Q9UIQ6,Q9UQB8,Q99538,Q99523,Q15375,Q92896,P11717,Q06481 8 +Motor behavior 0.8653610771113872 2.159337170805334 0.0308240183822303 1.0 0.1535465058085698 2 P04062 1 +Regulation of activin receptor signaling pathway 0.8633210934312565 2.150569499141508 0.0315101949224556 1.0 0.1551238002849093 2 P67870 1 +Activin receptor signaling pathway 0.8633210934312565 2.150569499141508 0.0315101949224556 1.0 0.1551238002849093 2 P67870 1 +Defense response 0.466662082644673 2.1481875706690152 0.0316988577010277 1.0 0.1551238002849093 170 P05067,O00584,Q08380,Q92692,Q8IV08,Q9NUD5,P02786,O95373,Q06481,Q9Y263,P11279,P60900,Q8IWZ3,P38571,O43657,P05556,Q9ULM6,P10321,Q7Z739,P51809,Q9Y624,P04062,O75179,Q9BQE5,Q07021,P42785,Q12899 27 +Oligosaccharide metabolic process 0.9777554458706516 2.1407957114420206 0.0322905159644757 1.0 0.1570319268997758 6 P06280,P10253,Q99519,P17900 4 +Regulation of carbohydrate catabolic process 0.7838454941895268 2.13658823279516 0.0326314975446835 1.0 0.1580053135625158 12 P05067 1 +Regulation of hydrolase activity 0.457584159149757 2.1362110609382614 0.0326622142876777 1.0 0.1580053135625158 138 P05067,Q4KMP7,P67870,Q99538,Q99523,O95831,O00170,Q9Y624,Q15392,Q15375,P50897,O43464,Q92542,Q92688,Q9Y263,P05556,Q14108,Q06481 18 +Vesicle mediated transport 0.4554669129770703 2.135854069598506 0.0326913103435928 1.0 0.1580053135625158 252 P05067,Q5VW38,Q08380,Q4KMP7,Q9H4M9,O75503,O15127,P02786,O43760,Q8NC96,P50897,P31751,Q9Y282,O15439,Q9BVK6,P11717,Q14108,Q06481,Q9Y263,P11279,Q8WTV0,Q15904,O14828,Q06787,Q7Z392,Q9UID3,Q9NVZ3,Q99523,O15118,P24390,P51790,Q6IAA8,Q99747,P05556,Q13501,Q96AX1,Q86Y82,Q7Z3T8,P15531,P49069,P61163,P51809,Q14849,Q9BRK5,Q15334,Q12907,O75436,Q9BZH6,P11233,O95721,Q9Y3E7,Q9UHY1,P84095 53 +Vacuolar transport 0.6165192955495316 2.1353360350861355 0.0327335714604306 1.0 0.1580053135625158 32 Q96AX1,P61421,P11279,Q9UID3,Q9Y3E7,Q99523,P51809,O15118,P11717,Q14108 10 +Cellular response to vitamin d 0.8592411260709931 2.133013039089807 0.0329236565816999 1.0 0.1586178168482023 2 Q13573 1 +Polysaccharide metabolic process 0.7262956920319745 2.124743878216704 0.0336079900197692 1.0 0.1610306572386919 16 P10253,Q15185,O43505 3 +Nucleotide transmembrane transport 0.8179881811125073 2.123412937050754 0.0337192640589454 1.0 0.1613336810691485 9 Q9H2D1,O15439,O43808,Q9BSK2 4 +Glycoside metabolic process 0.8662827845587229 2.1158169776117797 0.0343603765872972 1.0 0.1633771810876781 8 P06280,Q9BTY2,P04062 3 +Regulation of biological process involved in symbiotic interaction 0.8662738198768669 2.1157823369101543 0.0343633240181424 1.0 0.1633771810876781 8 Q9BTY2,Q12899 2 +Cellular response to calcium ion 0.8155844103062961 2.113687429130795 0.0345419728921241 1.0 0.1633771810876781 9 Q99538 1 +Lipid storage 0.7785043323179518 2.113607311994821 0.0345488208179562 1.0 0.1633771810876781 12 P07686,P17900,Q8WTV0 3 +Associative learning 0.8024156361947513 2.1098663303170384 0.0348698711152906 1.0 0.1642477219194452 10 P05067,Q99538 2 +Sphingosine biosynthetic process 0.9628571428571426 2.108073065719969 0.0350246698133616 1.0 0.1647417051496313 3 P04062,Q13510 2 +Glycolipid catabolic process 0.9681242337556196 2.1067603152887178 0.0351383610270803 1.0 0.1650861883349215 6 P06865,Q99519,P06280,P07686,P17900 5 +Glycosaminoglycan catabolic process 0.9652919559003664 2.1052644049168925 0.0352682987371175 1.0 0.1653822660505962 4 P54802,P16278,P15586 3 +Aminoglycan catabolic process 0.9652919559003664 2.1052644049168925 0.0352682987371175 1.0 0.1653822660505962 4 P54802,P16278,P15586 3 +Response to copper ion 0.9649971030286068 2.104180215044567 0.0353627297117 1.0 0.1656487646122786 4 P05067 1 +Regulation of mononuclear cell migration 0.7877812839662867 2.1003876543736646 0.0356947541363359 1.0 0.1656920287783705 11 P05067,Q99538,O94813 3 +Response to corticosteroid 0.6358199850575083 2.096300072528972 0.0360555803248094 1.0 0.1665372903674808 25 O94813,P04062,P16278,Q9H7B4 4 +Immune effector process 0.5354692019948358 2.0952756105520773 0.0361464992620987 1.0 0.1668320809270931 57 P05067,O75179,P11279,Q07021,Q92692,Q9UQ84,P51809,P02786,Q06481 9 +Retinal ganglion cell axon guidance 0.9580985761270028 2.090184489953516 0.0366012302495564 1.0 0.1677307656163735 3 O94813 1 +Regulation of system process 0.5552373942442348 2.0900463676213485 0.0366136347228205 1.0 0.1677307656163735 47 P05067,Q14126,Q9UQB8,P10253,P42892 5 +Response to growth factor 0.4988372776456105 2.085885176121901 0.0369890253924489 1.0 0.1688224087037126 76 P05067,O94813,Q9UQB8,Q99538,Q99523,P49427,O43464,Q92896,P23919,Q06481 10 +Mating 0.9555504151907844 2.0805931405914393 0.0374711622875294 1.0 0.170140078321769 3 P05067 1 +Mating behavior 0.9555504151907844 2.0805931405914393 0.0374711622875294 1.0 0.170140078321769 3 P05067 1 +Reproductive behavior 0.9555504151907844 2.0805931405914393 0.0374711622875294 1.0 0.170140078321769 3 P05067 1 +Nik nf kappab signaling 0.7294724350903253 2.072411880696976 0.0382270463322258 1.0 0.1726252290330625 15 P05067 1 +Regulation of endothelial cell migration 0.6520194224348971 2.071023586163424 0.0383565919457027 1.0 0.1728854587186616 22 O94813,P67870,Q99538,Q8WTV0 4 +Regulation of peptidase activity 0.5003834283868646 2.0607994125722775 0.0393221805565808 1.0 0.1764625843198749 69 P05067,Q99538,Q15392,Q15375,Q92542,O43464,Q92688,Q06481 8 +Neuron projection organization 0.6579933349711419 2.058192480743182 0.0395716601326812 1.0 0.1766807189535302 21 P05067,Q99538 2 +Protein targeting to lysosome 0.8496486334061014 2.0513083544642203 0.040236927403737 1.0 0.1787436955445953 8 Q14108 1 +Regulation of nitric oxide synthase activity 0.945186885359634 2.047947677029376 0.0405651265253848 1.0 0.1794249166787314 5 P06280 1 +Carbohydrate derivative catabolic process 0.6066042542678427 2.04534310156765 0.04082104420897 1.0 0.1796912016632456 31 P06865,Q99519,P06280,P07686,Q9BTY2,P17900,P04062,P54802,P08236,P16278,P15586 11 +Positive regulation of long term synaptic potentiation 0.9439297445767636 2.043364835067337 0.0410163358091699 1.0 0.1802416337144667 5 P05067,Q99538 2 +Negative regulation of developmental growth 0.7973695061708941 2.0396344247930753 0.041386750666772 1.0 0.1814944614354096 9 Q99538 1 +Bile acid and bile salt transport 0.8363933088535318 2.0341853707500723 0.0419329089773825 1.0 0.1833036141924044 2 O15439 1 +Response to ph 0.9431176957751052 2.0336751367056887 0.0419843606038248 1.0 0.183331707970035 3 Q99538 1 +Chemical synaptic transmission postsynaptic 0.7835276373850178 2.031520983622942 0.0422021731341049 1.0 0.1840217988574248 10 P05067,Q9UQB8 2 +Regulation of postsynaptic membrane potential 0.7835276373850178 2.031520983622942 0.0422021731341049 1.0 0.1840217988574248 10 P05067,Q9UQB8 2 +Protein localization to lysosome 0.7704617353533341 2.0270545273242675 0.0426568365685364 1.0 0.1849519519960722 11 Q14108 1 +Regulation of nik nf kappab signaling 0.7327439559505449 2.0251046436777713 0.0428566201877962 1.0 0.1851602588632255 14 P05067 1 +Diol metabolic process 0.9387471418769366 2.0244500736336417 0.0429238640419025 1.0 0.1851602588632255 5 P04062,Q13510 2 +Diol biosynthetic process 0.9387471418769366 2.0244500736336417 0.0429238640419025 1.0 0.1851602588632255 5 P04062,Q13510 2 +Glycosylation 0.6068650195344699 2.021896278045747 0.0431870683679143 1.0 0.1855692352944901 30 Q10472,O75503,O15118,P04062,O43505 5 +Positive regulation of wound healing spreading of epidermal cells 0.833537331701347 2.021772096262507 0.043199901732593 1.0 0.1855692352944901 2 P42345 1 +Response to amyloid beta 0.9436799255756988 2.0198281531984743 0.0434012158089331 1.0 0.18557033731639 6 P05067 1 +Cellular response to amyloid beta 0.9436799255756988 2.0198281531984743 0.0434012158089331 1.0 0.18557033731639 6 P05067 1 +Learning 0.6922886285107638 2.0131156305751423 0.04410246623719 1.0 0.1877862272630561 17 P05067,Q99538 2 +Regulation of monocyte chemotaxis 0.9372351124211992 2.011406620100197 0.0442825246677685 1.0 0.1883582917724055 3 Q99538 1 +Liposaccharide metabolic process 0.7539928076411514 2.0073490849229296 0.0447125060983466 1.0 0.1884878314249634 12 P06865,Q99519,P06280,P07686,P17900,P16278 6 +Sterol transport 0.6909926263345736 2.0067163118550675 0.0447798781607073 1.0 0.1884878314249634 17 Q8WTV0,Q9UHB6,P61916,Q14849,O15118 5 +Negative regulation of interferon gamma production 0.8298653610771167 2.005793078930486 0.044878329396949 1.0 0.1884878314249634 2 Q07021 1 +Regulation of dendritic cell differentiation 0.8298653610771152 2.0057930789304814 0.0448783293969494 1.0 0.1884878314249634 2 P01889 1 +Dendritic cell differentiation 0.8298653610771152 2.0057930789304814 0.0448783293969494 1.0 0.1884878314249634 2 P01889 1 +Regulation of leukocyte chemotaxis 0.788552634086384 2.0035643285012728 0.0451167502211804 1.0 0.1889685925930666 9 O94813,Q99538 2 +Negative regulation of natural killer cell mediated immunity 0.8282333741330108 1.9986844474918877 0.0456425068041348 1.0 0.1903935734370313 2 P01889 1 +Protection from natural killer cell mediated cytotoxicity 0.8282333741330108 1.9986844474918877 0.0456425068041348 1.0 0.1903935734370313 2 P01889 1 +Detection of other organism 0.8282333741330108 1.9986844474918877 0.0456425068041348 1.0 0.1903935734370313 2 P01889 1 +Regulation of fatty acid beta oxidation 0.8278253773969839 1.9969066347402 0.0458353263248814 1.0 0.1909391773899153 2 P31751 1 +Negative regulation of nervous system development 0.738942644424425 1.995159793341285 0.0460254546524032 1.0 0.1913614999354669 13 Q15375,Q06481 2 +Regulation of nervous system process 0.835255488406179 1.9951185959584017 0.0460299466305711 1.0 0.1913614999354669 8 P05067,P04062,Q9UQB8,Q15334 4 +Negative regulation of cell growth 0.6380834025620274 1.9940085070832387 0.0461511248413675 1.0 0.1917358135278676 22 O94813,P50897 2 +Mucopolysaccharide metabolic process 0.8840981659490029 1.99043146143972 0.046543427055357 1.0 0.1928451415745851 7 P15586,P16278,O43505 3 +Regulation of leukocyte migration 0.6862348384702428 1.9831841978233904 0.0473468583436442 1.0 0.1944727196943414 17 P05067,Q99538,O94813 3 +Metal ion homeostasis 0.5063206377273134 1.980453193472924 0.0476526278590188 1.0 0.1955981531519858 63 P05067,Q6P4Q7,P21399,P02786,P13693,Q658P3,P61421,P05026,Q15904,P07686,Q9Y487,P54709,P30519,P55011,Q9ULM6,Q9HD20,Q9UM00,P20020,Q15334 19 +Regulation of long term synaptic depression 0.8237454100367227 1.9791141816717035 0.0478031521239219 1.0 0.1960852815636158 2 Q06787 1 +Biological adhesion 0.4359252690672643 1.975652726215113 0.0481941225302522 1.0 0.1973988477947709 119 P05067,Q9NYL9,Q08380,Q8WTV0,Q07021,Q14126,Q92692,Q9UQB8,P02786,Q9Y624,Q15375,P35613 12 +O glycan processing 0.9277551020408156 1.9754282823489304 0.0482195658735318 1.0 0.1973988477947709 3 Q10472,O43505 2 +Neuron maturation 0.923917005080852 1.970132667902157 0.0488231678003177 1.0 0.1996044117839018 5 P05067 1 +Collateral sprouting 0.9268367276020402 1.9629120755288263 0.0496563913985856 1.0 0.2016047410692868 4 P05067 1 +Homeostatic process 0.4504716652765569 1.9622352506162213 0.0497351016673932 1.0 0.2016047410692868 227 P05067,Q9UIQ6,O75503,Q9UHB6,P61916,P02786,P10253,P50897,Q93050,P13693,Q06481,Q9Y263,Q658P3,Q9NYL9,Q8WTV0,Q15904,P07686,Q9Y487,O14773,O15118,P51790,Q92542,Q16763,P38571,Q5BJF2,P05556,P30519,Q13501,P55011,Q96AX1,Q9ULM6,Q9Y624,P04062,P42785,Q99873 35 +Chloride transport 0.8764964015600489 1.961928033699184 0.0497708634765821 1.0 0.2016047410692868 7 P55011,Q9UHG3,Q9C0H2,P51790 4 +Regulation of defense response 0.4924794396189033 1.9589597073190452 0.0501175056928897 1.0 0.2027421041728792 67 P05067,P11279,P60900,Q07021,Q92692,Q9NUD5,Q7Z739,P51809,P04062,O43657,Q06481 11 +Regulation of oxidoreductase activity 0.7181145454252285 1.9579878389062089 0.0502314397023635 1.0 0.2030695825656286 14 P06280 1 +Response to purine containing compound 0.7657480455616297 1.95713130156444 0.0503320331289378 1.0 0.2033077840557234 10 P05067 1 +Receptor metabolic process 0.6033222924404733 1.95645866411664 0.0504111472889008 1.0 0.2033077840557234 28 Q06787,Q99538,P02786,P42892,Q6IAA8,Q15334,P05556 7 +Polyol biosynthetic process 0.8252871580959896 1.956003256638438 0.0504647704701879 1.0 0.2033077840557234 8 P04062,Q13510 2 +Muscle cell differentiation 0.5268720976117366 1.955911977547544 0.0504755241208605 1.0 0.2033077840557234 53 Q13547,Q9NYL9,O75179,Q13045,Q9H4M9,Q7Z4V5,Q12802,O75844,Q8IV08,Q99523,Q96HC4,P58546,P42345,Q9H7B4,Q96PU8,Q16527,P05556 17 +Regulation of spontaneous synaptic transmission 0.9224489795918358 1.955241892143935 0.0505545261311211 1.0 0.2033077840557234 3 P05067,P05556 2 +Spontaneous synaptic transmission 0.9224489795918358 1.955241892143935 0.0505545261311211 1.0 0.2033077840557234 3 P05067,P05556 2 +Regulation of lysosomal lumen ph 0.92204081632653 1.953687661950148 0.0507381663109511 1.0 0.2037800978320459 3 P50897,O75503 2 +Copper ion transport 0.9211903194832658 1.9504484324159317 0.0511226940110125 1.0 0.2050312738063643 3 Q8N4V1 1 +Myotube differentiation 0.715218741070303 1.9446428443413055 0.0518179789576602 1.0 0.2065553420175125 14 Q13547,O75955,Q9H4M9,Q8IV08,Q99523,P42345,Q9H7B4,P05556,P35579 9 +Glutamate receptor signaling pathway 0.9195149165483848 1.944064863033923 0.0518876297627937 1.0 0.2065553420175125 3 P05067 1 +Sphingoid metabolic process 0.921476822105142 1.942922384959407 0.0520255368251265 1.0 0.2069165268007444 4 P04062,Q13510 2 +Positive regulation of chemotaxis 0.7623072066947144 1.942663764047428 0.0520567971437961 1.0 0.2069165268007444 10 O94813,Q99538,Q07021 3 +Chloride transmembrane transport 0.9187755102040808 1.941246515559866 0.0522283834842525 1.0 0.207464617491963 3 P55011,P51790 2 +Regulation of receptor mediated endocytosis 0.6665141382596389 1.9390075578260504 0.0525004178776467 1.0 0.2080316190003754 18 P05067 1 +Glycoside catabolic process 0.9154403117726604 1.9389594570105415 0.0525062751220697 1.0 0.2080316190003754 5 P06280,Q9BTY2,P04062 3 +Positive regulation of rho protein signal transduction 0.9171946960494136 1.9352188093956737 0.0529634505251748 1.0 0.2097080160022516 3 Q9Y624 1 +Negative chemotaxis 0.916515652574134 1.9326286642319244 0.0532819586882062 1.0 0.2106158418023004 3 O94813 1 +Peptidyl threonine modification 0.6186004113291658 1.931442177357067 0.0534283935042549 1.0 0.2106158418023004 23 P05067,Q10472,P67870 3 +Positive regulation of endocytosis 0.7123249964711367 1.931287790012258 0.0534474724988514 1.0 0.2106158418023004 14 P50897 1 +Positive regulation of leukocyte migration 0.759488484693632 1.9307949793259616 0.0535084114984441 1.0 0.2106158418023004 10 P05067,Q99538 2 +Golgi to lysosome transport 0.9181365392713444 1.9304470119669777 0.0535514746907774 1.0 0.2106158418023004 4 P11279 1 +Cell activation involved in immune response 0.5917403460959378 1.927477737890344 0.0539201198334018 1.0 0.2115706707935254 30 P05067,P11279,P02786 3 +Negative regulation of cell development 0.6640491021406317 1.9264334413322364 0.0540502751702636 1.0 0.211661467909309 18 Q15375,Q06481 2 +Cellular extravasation 0.9146510180487876 1.9255133464437808 0.0541651678864594 1.0 0.211661467909309 3 Q9Y624 1 +Acute inflammatory response 0.9157312930985136 1.921455426957963 0.0546743165715772 1.0 0.2129220538464271 4 Q9BQE5,P02786 2 +Cell volume homeostasis 0.9127791466019606 1.9183662256639853 0.0550645904638407 1.0 0.2141709939898087 3 P51790 1 +Response to catecholamine 0.695961989305333 1.914710276136056 0.055529462338699 1.0 0.215320417326517 15 P05067 1 +Antigen processing and presentation 0.6389605521143895 1.9146613050574892 0.0555357113777481 1.0 0.215320417326517 20 Q9UIQ6,P10321,Q99538,P01889,P04062 5 +Response to manganese ion 0.913221425321507 1.912065273696625 0.0558678222993114 1.0 0.2155251766271055 4 P05067 1 +Anion transport 0.5301430551868077 1.9116157875211408 0.0559254928502332 1.0 0.2156125607256646 48 Q9Y4C2,P55011,Q9UHG3,Q9C0H2,Q9H2D1,P08195,P28288,O43865,P08183,P51790,O15439,O43808,Q9H2J7,Q8TB61,P05556 15 +Vascular transport 0.754399005115378 1.9093260473713891 0.0562200441796734 1.0 0.2165992432131213 10 P55011,P08183,P02786 3 +Negative regulation of cell differentiation 0.5080718661339833 1.9090366046468004 0.0562573697798749 1.0 0.2165992432131213 59 P05067,O75179,Q96G23,Q99523,Q15375,Q92688,Q06481,Q99873 8 +Positive regulation of stress activated protein kinase signaling cascade 0.8130173883813895 1.9076359904171944 0.056438280075814 1.0 0.2165992432131213 8 P05067 1 +Vitamin d metabolic process 0.9098842878773856 1.9073049569085083 0.0564811086910903 1.0 0.2165992432131213 3 Q99538 1 +Neutrophil chemotaxis 0.81239689247 1.9051835898957343 0.0567562105715553 1.0 0.2170243508565449 8 O94813,Q07021 2 +Positive regulation of peptidyl serine phosphorylation 0.7060491428589662 1.902256960207721 0.0571375694629259 1.0 0.2181004433870024 14 P05067,P02786 2 +Cell morphogenesis involved in neuron differentiation 0.4803574864661551 1.9008179202552824 0.0573258659962852 1.0 0.218683616443078 74 P05067,O94813,Q9UQB8,P84095,P42892,Q15375,P05556,Q66K74,Q15334,P35613,Q06481 11 +Organic hydroxy compound transport 0.6280693273192303 1.8951962045676456 0.0580664128083883 1.0 0.2200228382615331 21 Q8WTV0,Q86Y82,Q9UHB6,P61916,Q14849,O15118,O15439 7 +Sulfur compound catabolic process 0.9088114313578196 1.8944942617446212 0.0581594353106562 1.0 0.2202261028337703 6 P16278 1 +Sequestering of metal ion 0.8041615667074653 1.89335671790286 0.0583104472041577 1.0 0.2204773695402968 2 O14617 1 +Protein transmembrane import into intracellular organelle 0.7276004118725081 1.8914956693657383 0.0585582085352596 1.0 0.2211919570255174 12 O60830,O14925,O95831,Q99595 4 +Regulation of multicellular organism growth 0.7158105973368041 1.891081220889146 0.0586135029187366 1.0 0.2212650750893082 13 P05067,Q99538 2 +Response to ketone 0.5857524102765871 1.8898380092917313 0.0587796283882364 1.0 0.221620435999003 30 O94813,Q9H7B4,P04062,Q96C86,O95831,P16278 6 +Positive regulation of mononuclear cell migration 0.8564999340215921 1.8865568375374389 0.0592199568370257 1.0 0.2224632545732565 7 P05067,Q99538 2 +Morphogenesis of a branching structure 0.7372871959641603 1.884870965453603 0.0594472609343958 1.0 0.223044963786152 11 O94813,Q15375 2 +Transferrin transport 0.9056951518814806 1.8838620739777885 0.059583634458753 1.0 0.2234204856044716 4 P02786 1 +Antigen processing and presentation of peptide antigen 0.7140681578373927 1.883193533453052 0.0596741450809552 1.0 0.2235563366084446 13 P10321,Q99538,P01889,Q9UIQ6 4 +Positive regulation of peptidase activity 0.563727406260431 1.8830581867182536 0.0596924829274456 1.0 0.2235563366084446 35 P05067,Q99538,O43464,Q92688,Q92542 5 +T cell tolerance induction 0.8013055895552887 1.8808029808899869 0.0599987245323747 1.0 0.2242939568584283 2 P01889 1 +Lymphocyte anergy 0.8013055895552887 1.8808029808899869 0.0599987245323747 1.0 0.2242939568584283 2 P01889 1 +Antigen processing and presentation of exogenous antigen 0.8044389666547112 1.873677156850076 0.0609749362655092 1.0 0.22711596042755 8 Q9UIQ6 1 +Protein localization to microtubule end 0.7992656058751539 1.8718288634275304 0.061230283699428 1.0 0.2279291757783425 2 Q15555 1 +Positive regulation of glucose transmembrane transport 0.7988576091391311 1.87003332907175 0.0614791897075153 1.0 0.2285062444123387 2 P31751 1 +Positive regulation of glucose import 0.7988576091391311 1.87003332907175 0.0614791897075153 1.0 0.2285062444123387 2 P31751 1 +Organic hydroxy compound metabolic process 0.4687776970938442 1.8691958766670684 0.0615955677373665 1.0 0.2285978966600154 84 P05067,Q8WTV0,Q9UBM7,Q99538,P61916,Q14849,O15118,Q15392,P04062,P38571,O15269,Q14739,Q13510 13 +Macrophage differentiation 0.8962850153354942 1.8681863151765277 0.0617361055940364 1.0 0.2288435894897545 5 P05067 1 +Bone resorption 0.895378070719498 1.8648243417906605 0.0622060301413913 1.0 0.2302476298362315 5 P02786 1 +Germ cell proliferation 0.7968176254589971 1.8610521262452089 0.062736815896748 1.0 0.2312997457941783 2 Q13162 1 +Intracellular lipid transport 0.8006084274399563 1.8584760213205849 0.0631014454589546 1.0 0.2314460721046863 8 P61916,O15118 2 +Regulation of endocytosis 0.5690405307661883 1.8580597761223565 0.0631605261041787 1.0 0.2314460721046863 33 P05067,P50897 2 +Cellular carbohydrate metabolic process 0.5246175123818196 1.857347520399154 0.0632617276756914 1.0 0.2314460721046863 47 P10253,Q14108,P16278,O43505 4 +Leukocyte chemotaxis 0.6396325264982187 1.8571220320473856 0.0632937943288585 1.0 0.2314460721046863 19 P35613,O94813,Q99538,Q07021 4 +Mitochondrion localization 0.6836972904446439 1.856303057193096 0.0634103735858846 1.0 0.2314460721046863 15 Q66K74,Q92692,Q8IWA4,O75153 4 +Regulation of neutrophil chemotaxis 0.8983457758760819 1.856257356023473 0.0634168842693383 1.0 0.2314460721046863 4 O94813 1 +Regulation of granulocyte chemotaxis 0.8983457758760819 1.856257356023473 0.0634168842693383 1.0 0.2314460721046863 4 O94813 1 +Alcohol biosynthetic process 0.5948660452166561 1.855805479457764 0.0634812892786327 1.0 0.2314460721046863 25 Q9UBM7,Q15392,P04062,O15269,Q13510 5 +Digestion 0.7304666711424377 1.8553641866848043 0.0635442379510162 1.0 0.2314460721046863 11 Q9Y624,Q9UHB6,Q8WTV0,Q9UDY2 4 +Neutrophil migration 0.7413660471062409 1.854124421072158 0.0637213616239831 1.0 0.2314460721046863 10 O94813,P35613,Q07021 3 +Regulation of peptidyl serine phosphorylation 0.6699782837655053 1.852430566255559 0.0639640194605766 1.0 0.2317989804701413 16 P05067,P02786 2 +Regulation of neurotransmitter receptor activity 0.8953248056989023 1.851524826744822 0.0640940864713588 1.0 0.2318496542690336 3 P05067 1 +Regulation of nmda receptor activity 0.8953248056989023 1.851524826744822 0.0640940864713588 1.0 0.2318496542690336 3 P05067 1 +Positive regulation of synaptic vesicle recycling 0.7935536515707935 1.846670065792206 0.0647949726348788 1.0 0.2337098104938191 2 Q9Y263 1 +Granulocyte chemotaxis 0.7505383093503917 1.846400265735465 0.064834108673625 1.0 0.2337140556812116 9 O94813,Q07021 2 +Protein import into mitochondrial matrix 0.748922305122945 1.8396611945123305 0.0658179940868715 1.0 0.2365682367734196 9 O60830,O14925,Q99595 3 +Biological process involved in interspecies interaction between organisms 0.442634355422046 1.8345287213007893 0.0665755484045858 1.0 0.2384558763973442 218 O00584,Q92692,Q9NUD5,P61916,P02786,Q9BTY2,P11717,Q14108,O95373,Q06481,P13693,Q9Y263,P11279,Q8WTV0,Q8IWZ3,O15118,O43657,P05556,Q9ULM6,P10321,Q7Z739,Q9UQB8,P51809,Q9Y624,O75179,Q07021,P08195,Q12899,P35613 29 +Lymphocyte mediated immunity 0.5767963213439866 1.8332701230245536 0.0667624101771793 1.0 0.2389516050415874 30 P11279,Q07021,Q92692,Q9UQ84,P51809,P02786 6 +Developmental growth involved in morphogenesis 0.55615470392427 1.8317372878826488 0.066990570441684 1.0 0.2389516050415874 35 P05067,Q15375,Q9Y263,O94813 4 +Carbohydrate derivative transport 0.6908651064337599 1.8316443039365409 0.0670044315910622 1.0 0.2389516050415874 14 O15439,Q8WTV0,P61916,O43808 4 +Digestive system process 0.7360474319179298 1.831505477324567 0.0670251309166174 1.0 0.2389516050415874 10 Q9Y624,Q9UHB6,Q8WTV0,Q9UDY2 4 +Cell chemotaxis 0.587743267854726 1.82738870533845 0.0676413463373388 1.0 0.2407328146815002 26 P55011,Q9ULM6,Q07021,O94813,Q99538,P35613 6 +Regulation of lipase activity 0.7239350229970744 1.8270212692112031 0.0676965715239212 1.0 0.2407901738144328 11 Q99523,P50897 2 +Regulation of response to extracellular stimulus 0.8873469387755096 1.8208581252858345 0.0686284259656457 1.0 0.2428420796956787 3 Q9UMX5,P80303 2 +T cell migration 0.7909697747083608 1.8201251464312471 0.0687399489441322 1.0 0.2429402452494011 8 Q9Y624,P05067 2 +Positive regulation of natural killer cell mediated immunity 0.8870974570286204 1.8198979921201603 0.0687745407616868 1.0 0.2429402452494011 3 P11279 1 +Positive regulation of natural killer cell mediated cytotoxicity 0.8870974570286204 1.8198979921201603 0.0687745407616868 1.0 0.2429402452494011 3 P11279 1 +Myeloid cell development 0.7330547619615456 1.8187552071144428 0.0689487849479308 1.0 0.2434160945667491 10 P05067,Q15904 2 +Modulation of excitatory postsynaptic potential 0.8882395419391305 1.8181963153729188 0.0690341329824186 1.0 0.24343823411956 4 P05067,Q9UQB8 2 +Regulation of phagocytosis 0.7209301417006103 1.813954182350298 0.0696847799540738 1.0 0.2451709658155615 11 Q06481 1 +Membrane invagination 0.731739055671511 1.8131444143522364 0.0698095504435711 1.0 0.2453579058252215 10 Q06481,P51790,P51809 3 +Behavioral response to pain 0.7853937168502678 1.8106509558480308 0.0701948991330652 1.0 0.2464025051096251 2 P42345 1 +Response to pain 0.7853937168502678 1.8106509558480308 0.0701948991330652 1.0 0.2464025051096251 2 P42345 1 +Regulation of synapse assembly 0.8361567829454079 1.809310778951971 0.0704027353485001 1.0 0.2469912487411484 7 P05067 1 +Regulation of immune effector process 0.5479389245876133 1.8082182412160537 0.0705725406849304 1.0 0.2471447444618827 36 O75179,P11279,Q07021,Q92692,P51809,P02786,Q06481 7 +Formation of extrachromosomal circular dna 0.8835397250490709 1.8061986684960043 0.0708873128451073 1.0 0.2479847643109805 3 Q9UQ84 1 +Endosome organization 0.6500172379969795 1.8020502859945908 0.071537494295282 1.0 0.2495835574733466 17 Q14108,P51790 2 +Cell part morphogenesis 0.4508499360033755 1.8016925688382663 0.0715937879006249 1.0 0.2495835574733466 93 P05067,O94813,Q92692,Q9UQB8,P84095,P42892,Q15375,Q9Y263,P05556,Q66K74,Q15334,P35613,Q06481 13 +Regulation of anatomical structure size 0.4672185660344811 1.8014617645801831 0.0716301286066913 1.0 0.2495835574733466 78 P55011,Q9NYL9,Q9HB40,Q8N0X7,O94813,Q9UQB8,Q9UHB6,P42345,P58546,O15143,O00165,P42892,Q15375,P51790,P20020,O60568,Q9NUQ9 17 +Vacuolar acidification 0.883095824577489 1.801102575374267 0.0716867139057266 1.0 0.2495835574733466 6 Q93050,P50897,O75503 3 +Leukocyte mediated cytotoxicity 0.7070301712970278 1.8001891776293817 0.071830772103747 1.0 0.2495835574733466 12 P11279,P04439,Q92692,P51809,P01889,P68371,Q9NUQ9 7 +Cellular component morphogenesis 0.4277017377054662 1.7979374389158291 0.0721869223509912 1.0 0.2502561266413586 106 P05067,Q9NYL9,Q12802,O94813,Q92692,Q9UQB8,P42892,Q15375,Q9Y263,P05556,Q66K74,Q16527,P35613,Q06481,Q15334 15 +Positive regulation of signaling 0.4399725074682216 1.7935510555309353 0.0728848546228599 1.0 0.2516837071861744 181 P05067,Q92692,Q9NUD5,Q99538,P02786,P42892,Q9UMX5,Q06481,Q92542,O43657,P05556,Q13501,Q12802,Q9UQB8,P51809,Q9Y624,P04062,O75179,Q07021,P67870,O43464,Q99873 22 +Natural killer cell mediated immunity 0.736893670780807 1.7893552099804126 0.0735576278163439 1.0 0.252819794233501 9 Q92692,P11279,P51809 3 +Regulation of chemotaxis 0.6571362380946406 1.789195025219186 0.0735834125818473 1.0 0.252819794233501 16 O94813,Q99538,Q07021 3 +Regulation of carbohydrate metabolic process 0.5786017487356423 1.7873676210937766 0.0738780912894083 1.0 0.2533272622009468 27 P05067 1 +Regulation of tube size 0.7822487734498815 1.785303188237115 0.0742121520082643 1.0 0.2540036535110388 8 Q9HB40 1 +Cell morphogenesis 0.4276114838305291 1.7822295418220175 0.0747118071664303 1.0 0.2553476033798898 136 P05067,Q07021,O94813,P07686,Q9UQB8,Q9Y624,P42892,Q15375,Q9Y263,P05556,Q66K74,P38571,P35613,Q06481 14 +Polysaccharide biosynthetic process 0.702534036478934 1.7801172224723898 0.075056778589954 1.0 0.2562930301139606 12 Q15185,O43505 2 +Carbohydrate transmembrane transport 0.7345767697059802 1.7796366603399902 0.0751354424810295 1.0 0.2562930301139606 9 Q06481 1 +Neutral amino acid transport 0.8775054775272595 1.7776462313636794 0.0754619757268906 1.0 0.2572643325307118 4 Q9H2J7 1 +Myeloid leukocyte migration 0.654720835131934 1.777255687160849 0.0755261809049856 1.0 0.2573407281859416 16 O94813,Q99538,Q07021 3 +Anion transmembrane transport 0.5604631964373669 1.775208750792142 0.0758634253676078 1.0 0.2583468528696689 32 P55011,Q9UHG3,Q9H2D1,P08195,P08183,P51790,O15439,O43808,Q8TB61,P05556 10 +Negative regulation of amyloid beta clearance 0.7772337821297451 1.774543548099844 0.0759732854753596 1.0 0.2584350931888338 2 P30533 1 +Aminoglycan biosynthetic process 0.8753633554316286 1.772869328305897 0.0762503621231176 1.0 0.2586065705666468 6 P06865,Q8NCH0,O43505 3 +Eyelid development in camera type eye 0.7768257853937219 1.7727359328011207 0.0762724739474052 1.0 0.2586065705666468 2 Q13547 1 +Production of molecular mediator involved in inflammatory response 0.7327976660123945 1.7721677314172184 0.0763667183874101 1.0 0.2586065705666468 9 Q8IV08 1 +Transition metal ion transport 0.7221446977782546 1.772134001019828 0.0763723160478488 1.0 0.2586065705666468 10 Q8N4V1,P02786,Q658P3 3 +Leukocyte differentiation 0.5149108828376843 1.771956889062296 0.0764017137990467 1.0 0.2586065705666468 46 P05067,Q15904,P02786,P04062,P05556,Q14739 6 +Regulation of cell killing 0.7779218467497554 1.7679839372999218 0.0770635890084037 1.0 0.2605604159938174 8 Q92692,P11279,Q9NUQ9,P01889 4 +Modified amino acid transport 0.8688190721588291 1.7659458567823427 0.0774049328362478 1.0 0.2612840852372686 5 Q9H2D1,O43772 2 +Endosomal transport 0.506582068406281 1.7653002167634817 0.0775133231178921 1.0 0.2614171627426539 51 Q13501,O75436,Q15904,Q4KMP7,Q9H4M9,O75503,Q9UID3,Q7Z3T8,Q9Y3E7,Q99523,Q6IAA8,Q9BVK6 12 +Regulation of signaling receptor activity 0.7096273009930578 1.764646934177606 0.0776231222483561 1.0 0.2615903468435295 11 P05067,Q15334,P05556 3 +Regulation of growth 0.4341134117696578 1.7612447347491065 0.0781969894701137 1.0 0.2630922755013609 101 P05067,O94813,Q99538,P02786,Q9ULC4,Q15375,P50897,O43464,Q5BJF2,Q9Y263 10 +Torc2 signaling 0.7739698082415383 1.760076779538084 0.0783947892748013 1.0 0.2634698239983362 2 Q96A49 1 +Regulation of stress activated protein kinase signaling cascade 0.6035434615089914 1.759454120561418 0.0785004063908116 1.0 0.2636576100407748 21 P05067 1 +Positive regulation of immune effector process 0.5578407761691222 1.7580368918116285 0.0787412323722334 1.0 0.2639138637538601 32 O75179,P11279,Q92692,P51809,P02786,Q06481 6 +Positive regulation of potassium ion transmembrane transporter activity 0.8708035677730452 1.757047118834117 0.0789097781487424 1.0 0.2643348770738886 3 P05026 1 +Substrate dependent cell migration cell extension 0.7731538147694832 1.756458016137245 0.0790102341077183 1.0 0.2645274667760858 2 Q9Y5K6 1 +Lipid catabolic process 0.4929909592578207 1.7457863165440053 0.0808480895509839 1.0 0.2698003725557769 57 P06865,Q99519,Q8WTV0,Q8NHP8,P06280,P07686,P17900,P50897,P38571,Q13510 10 +Adhesion of symbiont to host 0.8682419557524992 1.7425521613427144 0.0814118725363952 1.0 0.2713876010864026 4 Q8WTV0 1 +Lymphocyte migration 0.7149612868415189 1.741320574084478 0.081627401799424 1.0 0.2717240993253187 10 Q9Y624,P05067,P04062 3 +Response to angiotensin 0.76948184414525 1.740163505766077 0.0818303117138323 1.0 0.2717830423664275 2 O43865 1 +Angiotensin activated signaling pathway 0.76948184414525 1.740163505766077 0.0818303117138323 1.0 0.2717830423664275 2 O43865 1 +Endothelial cell migration 0.5681963852006149 1.739871541079527 0.0818815768555294 1.0 0.2717830423664275 28 Q8WTV0,O94813,P67870,Q99538,P42785 5 +Ameboidal type cell migration 0.4922823004589772 1.739859819976569 0.0818836354701515 1.0 0.2717830423664275 57 Q8WTV0,Q07021,O94813,Q7Z739,P67870,Q99538,P42785,P05556,Q06481 9 +Glucose import 0.7702477402154948 1.7371992926825723 0.082351999740075 1.0 0.2731903353446346 8 Q06481 1 +Response to camp 0.8167180693531191 1.7349871788543356 0.0827430761712755 1.0 0.2737711460257203 7 P05067 1 +Walking behavior 0.8661956832109472 1.7347880186459468 0.0827783591524733 1.0 0.2737711460257203 4 O15118,O43464 2 +Positive regulation of ossification 0.7662178702570421 1.7256659076720908 0.084407534771262 1.0 0.2767290690024817 2 P20020 1 +Positive regulation of binding 0.5143212086628818 1.7246714763023514 0.0845866942419588 1.0 0.2771688538838428 41 P05067 1 +Multicellular organism growth 0.589993164564292 1.723233564727849 0.0848462962487544 1.0 0.2778716202146706 22 P05067,Q99538 2 +Xenobiotic transport 0.8619289263377082 1.7227003666380782 0.0849427240055735 1.0 0.2780395277524277 3 P08183 1 +Intestinal absorption 0.766263532366736 1.7211830435470494 0.0852176137684157 1.0 0.2787910988162251 8 Q9Y624,Q9UHB6,Q8WTV0,Q9UDY2 4 +Developmental cell growth 0.5142998944058395 1.7178254812044087 0.0858284522716137 1.0 0.2797536071080459 40 P05067,O94813,Q15375,Q9Y263,P05556 5 +Cellular response to vitamin 0.8595918367346927 1.7136425568520997 0.0865943926556709 1.0 0.2815003566953357 3 Q96C86,Q13573 2 +Intermembrane lipid transfer 0.8541986123548906 1.7111782338536052 0.0870482154760416 1.0 0.282249187643553 5 P61916 1 +Negative regulation of mitochondrial fusion 0.8582846727209825 1.7085741425790837 0.0875298617416082 1.0 0.2830469321129633 3 P02786 1 +Transmembrane receptor protein serine threonine kinase signaling pathway 0.5380760087623817 1.7081863914892257 0.0876017627797818 1.0 0.2831136885086817 35 Q8N0X7,Q9UIQ6,P67870,P53999,Q9Y2U8,P05556,Q13573,Q92896,Q06481 9 +Regulation of toll like receptor signaling pathway 0.7626692886764518 1.7067150378388407 0.0878750307679354 1.0 0.283567381781016 8 P09429,Q14254,O75955,Q06481,O00571 5 +Protein targeting to mitochondrion 0.5182464702364445 1.7063602371390294 0.0879410291037083 1.0 0.2836317004670154 39 Q99595,Q7Z6Z7,O95831,O14925,O96008,O43464,O60830,P55786,Q8N4H5,O00170 10 +Trophoblast cell migration 0.8574793005705461 1.7054505806253235 0.0881104217129065 1.0 0.2837843644543564 3 Q07021 1 +Vitamin transmembrane transport 0.8569482025203988 1.705363576047214 0.0881266371344371 1.0 0.2837843644543564 6 P04062,Q8WTV0 2 +Vitamin transport 0.8569482025203988 1.705363576047214 0.0881266371344371 1.0 0.2837843644543564 6 P04062,Q8WTV0 2 +External encapsulating structure organization 0.6001301776082866 1.7035984879217587 0.0884561241669237 1.0 0.2845477306665357 20 P05067,Q92791,P13674,O60568,P05556,Q13162 6 +Grooming behavior 0.8577015876589922 1.702513980979955 0.0886590598715324 1.0 0.2850516092057573 4 P50897 1 +Cell morphogenesis involved in differentiation 0.4353473654527849 1.7005258237081524 0.0890320632455039 1.0 0.2861014683729477 97 P05067,Q96AX1,Q07021,O94813,Q9UQB8,P84095,P42892,Q15375,P05556,Q66K74,Q15334,P35613,Q06481 13 +Positive regulation of leukocyte degranulation 0.8559370109199176 1.699467258666202 0.089231178564942 1.0 0.2862930518104992 3 P11279 1 +Natural killer cell activation involved in immune response 0.8559370109199176 1.699467258666202 0.089231178564942 1.0 0.2862930518104992 3 P11279 1 +Natural killer cell degranulation 0.8559370109199176 1.699467258666202 0.089231178564942 1.0 0.2862930518104992 3 P11279 1 +Intracellular sterol transport 0.8509663434697177 1.699039895856399 0.0893116667678479 1.0 0.2864020480675208 5 P61916 1 +Carbohydrate transport 0.6835041756715836 1.6947220731702632 0.0901281563195222 1.0 0.2885694531769621 12 Q06481 1 +Positive regulation of tyrosine phosphorylation of stat protein 0.7588739290085667 1.6930012130350856 0.0904552363126902 1.0 0.2891655711200591 2 Q92769 1 +Regulation of neutrophil migration 0.8491868505180129 1.69235269804052 0.0905787455769551 1.0 0.2892702422105667 5 O94813,Q07021 2 +Regulation of epithelial cell migration 0.5478459421704006 1.6923359153030937 0.0905819436384558 1.0 0.2892702422105667 32 O94813,P67870,Q99538,Q8WTV0 4 +Regulation of gene expression by genomic imprinting 0.8532434270331599 1.6890122067666034 0.0912170907094793 1.0 0.2908460007759008 3 Q8NB78 1 +Long chain fatty acid biosynthetic process 0.7576499388004962 1.6875512197102764 0.0914974098642567 1.0 0.2915887953075716 2 Q96PU8 1 +Cellular response to nitrogen compound 0.4160623604325177 1.686141773492209 0.0917684956712245 1.0 0.2923014111990324 107 P05067,Q6ZWJ1,Q9BSK2,P61981,Q9NUD5,Q99538,P31751,P54132,Q06481,Q06787,O94813,Q92542,Q6IAA8,Q9H1E3,Q96A49,Q9UQB8,Q9UNS1,P20020,P38398,P42345,O43865,Q13243,O95831 23 +Regulation of small molecule metabolic process 0.5154507730373883 1.685862085824705 0.0918223660575077 1.0 0.2923217723971432 39 P05067,Q06481 2 +Cytokine production involved in inflammatory response 0.8472602852128321 1.6851092056594636 0.0919675038859408 1.0 0.2926325175326811 5 Q8IV08 1 +Antigen processing and presentation of exogenous peptide antigen 0.8453559277534965 1.6779455588485526 0.0933577274461008 1.0 0.2962904782915684 5 Q9UIQ6 1 +Iron ion homeostasis 0.6465022461653094 1.6770077747859304 0.0935409615226019 1.0 0.2966941965066496 15 Q658P3,Q15904,P02786,Q9Y487 4 +Suppression of viral release by host 0.8509476126811605 1.676801467766149 0.0935813106408824 1.0 0.2966941965066496 4 Q12899 1 +Osteoclast differentiation 0.8013549776226692 1.675911667502355 0.0937554960063566 1.0 0.2970934580088204 7 P02786 1 +Transepithelial transport 0.849795918367346 1.6756211985315417 0.0938124138473668 1.0 0.2971209012645255 3 P55011,P08183 2 +Cellular iron ion homeostasis 0.6891286245179367 1.674614722685897 0.0940098487413019 1.0 0.2974402048819095 11 Q15904,P02786 2 +Regulation of phospholipase a2 activity 0.848987528618153 1.672479666715095 0.0944297741193134 1.0 0.2977190811665378 3 P50897 1 +Glial cell development 0.6243045931437147 1.6713830310691995 0.0946460454517144 1.0 0.2977190811665378 17 P05067 1 +Granulocyte migration 0.6883837842342287 1.6713289770403514 0.0946567158915057 1.0 0.2977190811665378 11 O94813,P35613,Q07021 3 +Regulation of mitochondrial fusion 0.8491831929493093 1.6700771952285467 0.0949040914416992 1.0 0.2979391279946217 4 P02786,Q7Z6Z7 2 +Sodium ion transport 0.5940029819112954 1.6698866869634017 0.0949417848181659 1.0 0.2979391279946217 20 P55011,P05026,P08195,P54709,O43865,Q9H2J7 6 +T cell mediated immunity 0.7084442407389089 1.6693979248813515 0.0950385446339201 1.0 0.2980908401992085 9 P09429,P36915,Q92692,P01889,Q9NUQ9 5 +Myeloid cell differentiation 0.483816160322563 1.6688253131546391 0.0951520045651297 1.0 0.298294751582232 57 P05067,Q9NYL9,Q15904,P02786,P04062,Q99873,Q14739 7 +Positive regulation of cysteine type endopeptidase activity 0.580434286345789 1.6685206492069566 0.0952124162928402 1.0 0.2983322377175662 22 Q99538,Q92688,O43464 3 +Cellular response to increased oxygen levels 0.8421314739610133 1.6658079133415549 0.095751679497281 1.0 0.2995645785898167 5 Q15904,Q9Y487 2 +Cellular glucan metabolic process 0.666420420032886 1.665005046038894 0.0959117491055017 1.0 0.2999129706666196 13 P10253,Q15185 2 +Positive regulation of synapse assembly 0.7519379844961264 1.6620966383099296 0.0964933995208003 1.0 0.3003588780837047 2 Q9NUL3 1 +Positive regulation of pattern recognition receptor signaling pathway 0.750651797735111 1.6582103318540573 0.0972750201108327 1.0 0.3015602379513789 8 P09429,Q9NUD5,O75955,O75179 4 +Response to hydroxyurea 0.8447504142477296 1.6531710845253382 0.0982960495379279 1.0 0.303972263689112 4 P54132,Q9UNS1 2 +Innate immune response 0.4208328010448655 1.6522482808477954 0.0984839477841226 1.0 0.3041164620723814 103 O75179,P11279,O00584,Q07021,Q8IWZ3,P10321,Q92692,Q9NUD5,Q7Z739,P51809,Q12899,O95373,Q06481 13 +Energy reserve metabolic process 0.6414091313248332 1.6522143601947674 0.098490860057224 1.0 0.3041164620723814 15 P10253,Q15185,P31751,P42345 4 +Regulation of viral entry into host cell 0.8379612854708027 1.6500953030799286 0.0989234452752709 1.0 0.3052107382359524 5 Q12899 1 +Protein localization to mitochondrion 0.4976072987773945 1.6477546342032483 0.0994030317760357 1.0 0.3058929460523055 47 Q99595,P11233,Q7Z6Z7,O95831,O14925,O96008,O43464,Q9Y6C9,O60830,P55786,Q8N4H5,O00170 12 +Neuron recognition 0.8412716091877501 1.6476152797337125 0.099431642929344 1.0 0.3058929460523055 6 P05067 1 +Regulation of steroid biosynthetic process 0.793884316068904 1.6470834771317209 0.0995408888017232 1.0 0.3058929460523055 7 Q13510 1 +Positive regulation of endothelial cell migration 0.64007668725793 1.645718781887288 0.0998216703220027 1.0 0.3065346753977909 15 Q99538 1 +Negative regulation of blood pressure 0.8410467771970478 1.6415904946417257 0.1006748988821266 1.0 0.3073932238990925 3 Q9HB40 1 +Regulation of toll like receptor 9 signaling pathway 0.7470420236638136 1.640251587729341 0.1009528670672408 1.0 0.3075540833908964 2 P09429 1 +Toll like receptor 9 signaling pathway 0.7470420236638136 1.640251587729341 0.1009528670672408 1.0 0.3075540833908964 2 P09429 1 +Positive regulation of toll like receptor 9 signaling pathway 0.7470420236638136 1.640251587729341 0.1009528670672408 1.0 0.3075540833908964 2 P09429 1 +Negative regulation of hydrolase activity 0.4892330519986342 1.6389466834069053 0.10122436407153 1.0 0.3080763270333219 52 Q9Y624,P05067,Q99523,Q06481 4 +Intracellular transport 0.3409401260163518 1.638551302079423 0.1013067413961976 1.0 0.3081747069053305 421 P05067,O75503,P61916,O60830,P11717,Q14108,Q06481,P11279,Q15904,P10619,Q99523,O15118,Q13501,O43772,Q99595,O00148,Q14849,Q9UI26,Q8N4H5,Q5W0Z9,O75436,Q96EK5,Q9UHY1,Q92688,O43464,O95831,Q4KMP7,Q9Y282,P55786,O95373,Q8TEX9,Q16630,Q66K74,Q99747,O00170,P27348,Q96AX1,Q86Y82,Q12802,P51809,O14925,P43487,Q03519,Q5SNT2,Q5SRE5,Q12907,Q9BZH6,Q9Y3E7,Q7Z6Z7,Q9UH62,P82979,Q9C0E2,Q9H4M9,P31751,Q9BVK6,Q00577,P61421,P05026,Q7Z392,Q9UID3,Q9NPA8,Q969Q5,P24390,O96008,Q6IAA8,Q9NS69,Q9Y4C2,Q7Z3T8,O75844,Q14203,Q6NUQ1,Q9BW83,Q9Y678,A4D1P6,O00165,O43865,P35606,P50402,Q96CS3,Q6ZWJ1,P61981,P55060,O00410,P40616 84 +Golgi to vacuole transport 0.8386821106434944 1.638052681253295 0.1014107046903789 1.0 0.3083386216190929 6 P11279 1 +Steroid hormone biosynthetic process 0.8403535253495202 1.6363844376792172 0.1017591541288491 1.0 0.3086585520628095 4 Q9UBM7 1 +Monocyte chemotaxis 0.8335676538262891 1.6335229253432508 0.1023590631430266 1.0 0.3086648908752901 5 Q99538 1 +Glial cell migration 0.6888752574349636 1.6286745873342243 0.1033819252293355 1.0 0.3108020086118256 10 P07686 1 +Modulation by host of symbiont process 0.6063298785310733 1.627248950287545 0.1036842352562106 1.0 0.3115587293667588 18 Q13547,P11717,Q13573,Q06787 4 +Ion transmembrane transport 0.4080537884493446 1.626013695704586 0.1039467418994759 1.0 0.3117389624330606 121 P05067,Q9C0H2,Q13423,O15439,Q8TB61,P61421,P05026,Q06787,P54709,P51790,Q9H2J7,P05556,P55011,Q9Y4C2,O43772,Q9HD20,O75844,Q9UHG3,Q9UM00,Q9H2D1,Q15334,P08195,Q93034,Q8N4V1,P08183,O43808 26 +Response to transforming growth factor beta 0.5656461966724621 1.624367295726043 0.1042974425847238 1.0 0.3118113759591839 23 Q13177,Q9Y2U8,Q06481,Q13573,Q92896,P05556 6 +Bone remodeling 0.834851716176418 1.6238958478023102 0.1043980388999699 1.0 0.3118122566018902 6 P02786 1 +Establishment of protein localization to vacuole 0.6875057728453984 1.6227296388931411 0.1046472125708866 1.0 0.3119082499490369 10 Q14108 1 +Protein targeting to vacuole 0.6875057728453984 1.6227296388931411 0.1046472125708866 1.0 0.3119082499490369 10 Q14108 1 +Positive regulation of leukocyte chemotaxis 0.7869176701596053 1.6201430868981106 0.1052015436664888 1.0 0.3130623027329974 7 Q99538 1 +Low density lipoprotein particle clearance 0.6960157743481639 1.6165856560902634 0.1059677502018243 1.0 0.3142957342329673 9 Q8WTV0 1 +Cellular response to cold 0.7417380660954774 1.6165597106334737 0.1059733545992593 1.0 0.3142957342329673 2 Q13217 1 +Multi organism reproductive process 0.4061020952114513 1.614724081719978 0.106370460079626 1.0 0.3150182408418747 119 P05067,Q9BQE5,Q9UIQ6,Q07021,Q15056,P07686,Q92692,Q7Z739,Q8NB78,P11717,P35613,P05556 12 +Sodium ion transmembrane transport 0.613161688699891 1.6142539460304803 0.1064723550548629 1.0 0.315168408688842 17 P55011,P05026,P08195,P54709,Q9H2J7 5 +Negative regulation of cyclin dependent protein serine threonine kinase activity 0.8339151292915967 1.6138040209300688 0.1065699421249979 1.0 0.3153056865274446 3 O95373 1 +B cell mediated immunity 0.6129496058150682 1.6131637876559315 0.1067089285297508 1.0 0.315565260786588 17 Q9UQ84,P02786,Q07021 3 +Modulation by host of viral process 0.6749711525840614 1.611996108429962 0.1069627865624123 1.0 0.3161641271554357 11 P11717,Q06787 2 +Kidney epithelium development 0.6945718350776919 1.6104347372324332 0.1073029822238957 1.0 0.3168654491858639 9 O94813 1 +Intracellular protein transmembrane transport 0.602842262729067 1.608893134829486 0.1076397108988558 1.0 0.3174031130288579 18 Q99595,O14925,P31751,O60830,O95831 5 +Postsynapse organization 0.5517594339213762 1.607939305893624 0.1078484722379793 1.0 0.3175624311665417 26 Q15375,Q99538 2 +Detection of biotic stimulus 0.8318575141634613 1.6057796269394342 0.1083223385025879 1.0 0.3183487532985366 3 Q8WTV0 1 +Detection of external biotic stimulus 0.8318575141634613 1.6057796269394342 0.1083223385025879 1.0 0.3183487532985366 3 Q8WTV0 1 +Phosphatidylcholine metabolic process 0.7375207176846618 1.604990493032329 0.1084958968981859 1.0 0.3187066971384212 8 Q8WTV0 1 +Transforming growth factor beta receptor signaling pathway 0.6017499883974893 1.6031382719281924 0.1089041300229312 1.0 0.3194466749912823 18 Q9Y2U8,Q06481,Q13573,Q92896,P05556 5 +Cell cell junction maintenance 0.7384740922072659 1.6019671575852008 0.109162872207513 1.0 0.3194466749912823 2 Q96AC1 1 +Adherens junction maintenance 0.7384740922072659 1.6019671575852008 0.109162872207513 1.0 0.3194466749912823 2 Q96AC1 1 +Negative regulation of catalytic activity 0.4046879723653178 1.5973619116012416 0.1101850575195924 1.0 0.3216734941432576 119 P05067,P06280,O94813,Q99523,Q9Y624,Q9H7B4,Q15392,P04062,Q06481 9 +Gdp metabolic process 0.7372501019991891 1.5964925149998357 0.1103788755717114 1.0 0.3219599899606445 2 Q9UDY2 1 +Regulation of vesicle mediated transport 0.4403633542213289 1.5942649322936286 0.110876708541719 1.0 0.3230799311364715 85 P05067,Q9H4M9,P30533,P50897,P31751,Q06481,P09429,P11279,Q8WTV0,O75955,Q06787,Q9Y5K6,P61020,Q7Z3T8,P51809,Q4J6C6,Q6NUQ1,Q15334,Q12907,P11233,Q9Y3E7 21 +Leukocyte mediated immunity 0.5028623044942087 1.5931125865754563 0.1111349362279188 1.0 0.3234630567319044 39 P11279,Q07021,Q92692,Q9UQ84,P51809,P02786 6 +Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway 0.8285714285714267 1.592957716481764 0.1111696770287329 1.0 0.3234630567319044 3 P10321,P01889 2 +Regulation of leukocyte mediated cytotoxicity 0.7787156147243287 1.5883573845188927 0.1122055481563601 1.0 0.3250855921934188 7 Q92692,P11279,Q9NUQ9,P01889 4 +Positive regulation of cell killing 0.7787156147243287 1.5883573845188927 0.1122055481563601 1.0 0.3250855921934188 7 Q92692,P11279,Q9NUQ9,P01889 4 +Cellular carbohydrate biosynthetic process 0.6496902717182382 1.587315610218102 0.1124411814937871 1.0 0.3253291139366763 13 Q15185,O43505 2 +Intraciliary transport involved in cilium assembly 0.7348021215830256 1.5855393716562485 0.1128438388609014 1.0 0.3260344982949648 2 A0AVF1 1 +Cellular response to peptide 0.4737795946704486 1.584073972745907 0.1131768864755242 1.0 0.3268433818151045 57 P05067,Q9UQB8,Q99538,Q06481 4 +Membrane raft organization 0.6877340010881045 1.5812652833409746 0.1138173939658822 1.0 0.3280313984456287 9 P50897 1 +Motor neuron axon guidance 0.8249630803406817 1.577497423241952 0.1146811145410293 1.0 0.3297952462536748 4 O94813 1 +Gliogenesis 0.491975218734361 1.5770750512641412 0.1147782570544782 1.0 0.3299205082560327 44 Q13547,P05067,Q96P11,P07686,Q96G23,P04062,P31751,Q92542,Q9NR50 9 +Negative regulation of cell killing 0.8238440371463672 1.57449812662559 0.1153723342900474 1.0 0.3311643180530639 3 P01889 1 +Zymogen activation 0.7745584715810028 1.5722200572121066 0.1158995254236359 1.0 0.3315293486245007 7 Q99538 1 +Pyramidal neuron differentiation 0.8230436178878678 1.571371068771351 0.1160964820663341 1.0 0.3315293486245007 3 P04062 1 +Late endosome to vacuole transport 0.731538147694826 1.570927448188845 0.1161995020840787 1.0 0.3315293486245007 2 Q9Y3E7 1 +Regulation of inflammatory response 0.5632454161546765 1.5694417982787687 0.1165450310619571 1.0 0.3320535660566728 22 P05067,P04062,P60900 3 +Mitochondrial fusion 0.6651292938678003 1.5682667242497814 0.116818898260727 1.0 0.3325261010593139 11 Q8IWA4,P02786,Q7Z6Z7 3 +Positive regulation of lymphocyte mediated immunity 0.6034335789254793 1.564143960017458 0.1177837642660144 1.0 0.334648619643899 17 Q92692,P11279,P02786 3 +Histone h3 k9 acetylation 0.8205340938722185 1.5615640704945095 0.1183907192138868 1.0 0.3358591664771941 3 Q03164 1 +Positive regulation of epithelial cell migration 0.5681194119811777 1.560174214178827 0.1187187174314072 1.0 0.3358591664771941 21 Q99538 1 +Cholesterol efflux 0.8175555871116738 1.5598033271409415 0.1188063649858366 1.0 0.3358591664771941 6 Q8WTV0,P61916 2 +Regulation of cysteine type endopeptidase activity 0.4924156912974547 1.5595495402634705 0.1188663688049453 1.0 0.3358591664771941 41 Q99538,Q15392,Q15375,Q92688,O43464 5 +Positive regulation of anion transmembrane transport 0.8201068343918552 1.5588776875549342 0.1190253322483585 1.0 0.3358591664771941 4 P08183,P05556 2 +Regulation of neuron differentiation 0.5931768499464154 1.55787054426907 0.1192639390313581 1.0 0.3362216449707289 18 P05067 1 +Positive regulation of inflammatory response 0.6724617072394693 1.5572307456127106 0.1194157111525628 1.0 0.3364954387031257 10 P05067 1 +Synaptic vesicle maturation 0.8188509035351957 1.554983937024213 0.1199498949665565 1.0 0.3373182375606955 3 P51790 1 +Export across plasma membrane 0.7700298390890457 1.5546207315007767 0.1200364233385551 1.0 0.3373182375606955 7 P54709,O15439,P08183,P05026 4 +Cellular lipid catabolic process 0.4830905055000819 1.5536511366335064 0.1202676544686933 1.0 0.3378138451476939 49 P06865,Q99519,Q8WTV0,Q8NHP8,P06280,P07686,P17900,P50897,Q13510 9 +Response to mitochondrial depolarisation 0.7243890125857188 1.5515520057615142 0.1207694545291713 1.0 0.3387596954606413 8 Q13501,P04062,O43464 3 +Synapse assembly 0.6314174659085487 1.5503738297755507 0.1210518161208056 1.0 0.3392426180499773 14 P05067 1 +Histone lysine demethylation 0.8177338357757515 1.5497728956490502 0.1211960347311253 1.0 0.3393378744154339 4 Q8NB78 1 +Negative regulation of response to external stimulus 0.5149825808848842 1.548355047689798 0.1215368377488712 1.0 0.3399421769296297 35 P55011,Q07021,O94813,Q96G23,Q7Z739,P80303,P04062,Q9UMX5,O43657 9 +Multicellular organismal homeostasis 0.4730859472381763 1.5474828706214432 0.1217468518344981 1.0 0.3399421769296297 55 Q13501,P55011,Q9UIQ6,O14773,P02786,Q9Y624,P42785,P04062,P51790,P05556,P38571,Q06481 12 +3 phosphoadenosine 5 phosphosulfate biosynthetic process 0.7262341901264862 1.5471653030038257 0.1218233903054688 1.0 0.3399421769296297 2 Q8TB61 1 +3 phosphoadenosine 5 phosphosulfate metabolic process 0.7262341901264862 1.5471653030038257 0.1218233903054688 1.0 0.3399421769296297 2 Q8TB61 1 +Regulation of t cell mediated cytotoxicity 0.8106523135924281 1.5468112160139156 0.121908774835248 1.0 0.3399421769296297 5 Q92692,Q9NUQ9,P01889 3 +Positive regulation of t cell mediated cytotoxicity 0.8106523135924281 1.5468112160139156 0.121908774835248 1.0 0.3399421769296297 5 Q92692,Q9NUQ9,P01889 3 +Glycoprotein biosynthetic process 0.525863879176564 1.54647886531815 0.1219889604343806 1.0 0.3399605453838398 32 Q10472,O15118,Q10471,Q92542,O43505,Q8NCH0 6 +Regulation of cellular response to transforming growth factor beta stimulus 0.6602044527192552 1.546326261601896 0.1220257926422423 1.0 0.3399605453838398 11 Q13573,Q92896 2 +Tyrosine metabolic process 0.7258261933904564 1.545336580807595 0.1222648715783043 1.0 0.3400112079076874 2 P16930 1 +L phenylalanine metabolic process 0.7258261933904564 1.545336580807595 0.1222648715783043 1.0 0.3400112079076874 2 P16930 1 +Aromatic amino acid family catabolic process 0.7258261933904564 1.545336580807595 0.1222648715783043 1.0 0.3400112079076874 2 P16930 1 +Tyrosine catabolic process 0.7258261933904564 1.545336580807595 0.1222648715783043 1.0 0.3400112079076874 2 P16930 1 +Iron ion transport 0.722731583887146 1.5447926859623986 0.1223964170037588 1.0 0.3402191946422299 8 Q8N4V1,P02786 2 +Response to nerve growth factor 0.7670720938166014 1.5431153184155144 0.1228027986511361 1.0 0.3404308110288364 7 P05067 1 +Cell cell adhesion via plasma membrane adhesion molecules 0.8129369834059563 1.542644858721655 0.1229169676121131 1.0 0.340440742054782 6 Q14126,Q92692,P35613 3 +Homophilic cell adhesion via plasma membrane adhesion molecules 0.8129369834059563 1.542644858721655 0.1229169676121131 1.0 0.340440742054782 6 Q14126,Q92692,P35613 3 +Visual behavior 0.8088890157608012 1.5401210173783324 0.1235308575722857 1.0 0.3405237578781817 5 P05067 1 +Actomyosin structure organization 0.5004000955090744 1.5387705887198868 0.123860312451355 1.0 0.3411060482850492 38 Q9NYL9,Q07157,Q16527,Q13177,Q13045,Q12802,Q9NQW6,Q7Z460,P35580,Q9Y624,P42345,P60903,O75116,Q96AC1,P63167,P05556,P35579,Q14315 18 +Response to l glutamate 0.8148135775516269 1.5385629072011475 0.1239110398775813 1.0 0.3411060482850492 4 Q9UQB8 1 +Positive regulation of extracellular matrix assembly 0.724194206446346 1.538020512189985 0.1240435994981687 1.0 0.3411060482850492 2 Q7Z460 1 +Regulation of extracellular matrix assembly 0.724194206446346 1.538020512189985 0.1240435994981687 1.0 0.3411060482850492 2 Q7Z460 1 +Positive regulation of basement membrane assembly involved in embryonic body morphogenesis 0.724194206446346 1.538020512189985 0.1240435994981687 1.0 0.3411060482850492 2 Q7Z460 1 +Negative regulation of peptidase activity 0.5209189044636486 1.536573524424369 0.1243977801067059 1.0 0.3419272911236557 33 P05067,Q06481 2 +Alcohol metabolic process 0.4577453204929264 1.5342480447216689 0.1249686420700786 1.0 0.3427629636898259 62 P05067,Q8WTV0,Q9UBM7,Q9BQE5,P61916,Q14849,O15118,Q15392,P04062,O15269,Q14739,Q13510 12 +Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis 0.7229702162382747 1.5325322484684127 0.125391145971859 1.0 0.3429734721229417 2 Q13177 1 +Positive regulation of activated t cell proliferation 0.7229702162382738 1.5325322484684092 0.1253911459718599 1.0 0.3429734721229417 2 P09429 1 +Regulation of natural killer cell mediated immunity 0.8065290840309112 1.5311634221664747 0.1257290083998725 1.0 0.3437448955230974 5 Q92692,P11279 2 +Glial cell proliferation 0.8108385795023487 1.523636419470519 0.1275995601654409 1.0 0.3470099346018638 3 P04062 1 +Amino acid salvage 0.8099956925096004 1.5203364362085725 0.1284264409881959 1.0 0.3487964698563397 3 Q13126 1 +L methionine salvage from methylthioadenosine 0.8099956925096004 1.5203364362085725 0.1284264409881959 1.0 0.3487964698563397 3 Q13126 1 +Head development 0.3999538857024534 1.5198936649099446 0.1285377029186589 1.0 0.3489447252514035 122 P05067,O75503,Q02880,P58546,P50897,Q13547,P61421,O94813,Q9UID3,Q15375,P54802,Q92542,Q66K74,P05556,P27348,Q9UQB8,Q9BRK5,P04062,O95456,Q9BZH6,Q92688,O43464 22 +Cell growth 0.4347122001634341 1.5190929604499257 0.128739098418146 1.0 0.3491835369870154 83 P05067,Q7Z4V5,O94813,P02786,Q15375,P50897,P05556,Q5BJF2,Q9Y263 9 +Central nervous system neuron development 0.7159114184924253 1.5169460722523815 0.129280300094932 1.0 0.3503427850724017 8 O94813 1 +Synaptic vesicle membrane organization 0.8085714285714269 1.514759379104374 0.1298333508986071 1.0 0.3512872873062495 3 O95721,O43760 2 +Amino acid import across plasma membrane 0.8017483430643804 1.5130046232826877 0.130278484493167 1.0 0.3522725643497714 5 P08195 1 +Cellular defense response 0.8077470888089842 1.5115309498505594 0.1306532293193045 1.0 0.3528108890978065 3 Q08380 1 +Plasma lipoprotein particle clearance 0.6618896292685128 1.5110010898115454 0.1307881732097033 1.0 0.3528108890978065 10 Q8WTV0 1 +Positive regulation of amino acid transport 0.8069371867095403 1.508299341839492 0.131477931607997 1.0 0.3538066542440724 4 P05556 1 +Positive regulation of amine transport 0.8069371867095403 1.508299341839492 0.131477931607997 1.0 0.3538066542440724 4 P05556 1 +Regulation of neuronal synaptic plasticity 0.7120408489943563 1.501119971705155 0.1333245340649487 1.0 0.3569884463193324 8 P05067,Q15334 2 +Synapse organization 0.4708133274852882 1.501096886261615 0.1333305040693146 1.0 0.3569884463193324 53 P05067,Q9UQB8,Q15375,Q99538 4 +Positive regulation of translation in response to endoplasmic reticulum stress 0.804897959183672 1.5003698002848258 0.1335186378151864 1.0 0.3569884463193324 3 Q13217,O00571 2 +Positive regulation of translation in response to stress 0.804897959183672 1.5003698002848258 0.1335186378151864 1.0 0.3569884463193324 3 Q13217,O00571 2 +Regulation of translation in response to endoplasmic reticulum stress 0.804897959183672 1.5003698002848258 0.1335186378151864 1.0 0.3569884463193324 3 Q13217,O00571 2 +Positive regulation of immune system process 0.4270927258472215 1.4991586600226057 0.1338324767509882 1.0 0.3576417358315253 89 P05067,O75179,P11279,Q07021,Q92692,Q99538,P02786,Q06481 8 +Neurotransmitter transport 0.5630802372715609 1.4981904074378292 0.1340837871953284 1.0 0.3581578645386712 20 Q9H2J7,O95721,P50897,P05556 4 +Pteridine containing compound metabolic process 0.5985125138843459 1.4956081782618351 0.1347557907109975 1.0 0.3590183485104335 16 Q92820,Q9H2D1 2 +Protein o linked glycosylation via serine 0.8028381658768875 1.4922981094219272 0.1356210121538414 1.0 0.3599101851514306 3 Q10472 1 +Neuronal action potential 0.7962477464083453 1.4920917600585712 0.1356750917226685 1.0 0.3599101851514306 5 P04062,Q06787 2 +Amino acid transport 0.6189159215180464 1.4903404789363284 0.1361347341775023 1.0 0.3607690560122872 14 Q9H2J7,P08195,P05556 3 +Hormone biosynthetic process 0.7986810326258234 1.489577206167532 0.1363354390359987 1.0 0.3608464895675365 6 Q9UBM7 1 +Tolerance induction 0.8019599836667977 1.4891553715976922 0.1364464596513261 1.0 0.3608464895675365 4 P09429,Q9ULM6,P01889 3 +Regulation of neurotransmitter uptake 0.8020040022974979 1.4890286644211026 0.1364798207281954 1.0 0.3608464895675365 3 P05556 1 +Positive regulation of phagocytosis 0.7950963715605296 1.4877117533292454 0.1368269266512825 1.0 0.3608464895675365 5 Q06481 1 +Regulation of tolerance induction 0.8016326530612229 1.487573075485705 0.1368635183806956 1.0 0.3608464895675365 3 P09429,P01889 2 +Cellular process involved in reproduction in multicellular organism 0.4886495816931632 1.4875531229858163 0.1368687836963833 1.0 0.3608464895675365 39 O94813,Q92692,P07686,Q8NB78,P05556 5 +Polyol metabolic process 0.607662536255183 1.486592036150547 0.1371225924461407 1.0 0.3608464895675365 15 P04062,Q13510 2 +Formation of translation preinitiation complex 0.7084735999673574 1.4865201443293867 0.1371415925918524 1.0 0.3608464895675365 8 Q15056,P55010,Q9ULC4,Q7Z478 4 +Myeloid leukocyte activation 0.637449621317671 1.485327212139123 0.1374571667522279 1.0 0.3615223304969959 12 P05067,Q92692 2 +Monosaccharide metabolic process 0.4687739505466676 1.4842301021887412 0.1377478864487831 1.0 0.3621322531448154 53 Q9BTY2,P10253 2 +Regulation of transporter activity 0.5044647405964523 1.4748694896402426 0.1402476344336347 1.0 0.3656309588986539 35 Q9Y4C2,P05067,P05026,Q06787,P54709,O43865,P08183,Q03164,Q15334,P05556 10 +Purine nucleoside diphosphate biosynthetic process 0.7099143206854379 1.4739333160508938 0.14049954644363 1.0 0.3656309588986539 2 P00568 1 +Adp biosynthetic process 0.7099143206854379 1.4739333160508938 0.14049954644363 1.0 0.3656309588986539 2 P00568 1 +Positive regulation of exocytosis 0.6439568257010968 1.4736824050499076 0.1405671223931917 1.0 0.3656407995669122 11 P11279 1 +Reactive nitrogen species metabolic process 0.605001699320765 1.4734410097772277 0.1406321591320196 1.0 0.365655491459394 15 P06280 1 +Positive regulation of leukocyte mediated immunity 0.552407220934858 1.4706731049990738 0.1413795430092101 1.0 0.3669788559475999 21 Q92692,P11279,P02786 3 +Positive regulation of regulated secretory pathway 0.7970000749899782 1.4700638245132542 0.1415444688105289 1.0 0.3670974281661444 4 P11279 1 +Regulation of plasma lipoprotein particle levels 0.6335245726844878 1.467321478506494 0.1422886235508542 1.0 0.3685616555332813 12 Q8WTV0 1 +Purine containing compound transmembrane transport 0.7473496772471834 1.4661913610340287 0.1425961614642967 1.0 0.369047736921259 7 O15439,O43808 2 +Histone h3 k9 demethylation 0.7074663402692825 1.4629359346834765 0.1434849100083834 1.0 0.3701033057903716 2 Q7LBC6 1 +Cellular response to mechanical stimulus 0.7883052893736797 1.461860408562203 0.1437794661834117 1.0 0.3705663970676853 5 Q9Y624 1 +Response to peptide 0.432927816818983 1.4618408839568462 0.1437848177025662 1.0 0.3705663970676853 77 P05067,Q6ZWJ1,Q96A49,Q9BSK2,Q9UQB8,Q99538,Q99523,P20020,P42345,O43865,P31751,Q9UNS1,Q9H1E3,P35613,Q06481,Q9NR50,Q13243 17 +Developmental growth 0.4288039319474356 1.459256065711791 0.144494642739088 1.0 0.3716180097512804 83 P05067,Q9BZH6,Q7Z4V5,Q12802,Q15056,O94813,Q99538,Q15375,P05556,O43464,Q9Y263 11 +Negative regulation of small gtpase mediated signal transduction 0.6589612151693887 1.4578259755388885 0.144888516544924 1.0 0.3718631406574134 9 O94813,Q9NUQ9,P05556 3 +Protein insertion into er membrane by stop transfer membrane anchor sequence 0.7869817760017462 1.4568189992854153 0.1451663499271944 1.0 0.3718631406574134 5 Q5J8M3 1 +Transmission of nerve impulse 0.7439936860506343 1.4530691202879082 0.1462045637570332 1.0 0.372842128462566 7 P04062,Q06787 2 +Maintenance of blood brain barrier 0.743974475029336 1.4529939781528745 0.146225425974785 1.0 0.372842128462566 7 P55011,Q9Y624,Q9UDY2,P05556 4 +Regulation of steroid metabolic process 0.6485590721862915 1.4524922713645756 0.1463647765982103 1.0 0.372842128462566 10 Q13510 1 +Striated muscle cell development 0.6484827839582191 1.4521567838548388 0.1464580159733699 1.0 0.372842128462566 10 Q9NYL9,P05556,Q16527,Q12802 4 +Protein localization to membrane raft 0.7920377432479986 1.4509500179318455 0.1467937785678217 1.0 0.3731896786946131 4 P05026,O75955 2 +Branching morphogenesis of an epithelial tube 0.6988024887140332 1.4468749236714007 0.1479319575621278 1.0 0.3752851515080433 8 O94813 1 +Stress activated protein kinase signaling cascade 0.5257179166550805 1.4464393390345038 0.1480540147087201 1.0 0.3754401023729777 26 P05067 1 +Positive regulation of i kappab kinase nf kappab signaling 0.5285983140138906 1.4453307509555935 0.1483650042882165 1.0 0.3759190664208021 24 O43657,O75179,P02786,Q12802 4 +Protein targeting 0.4219012292974841 1.4446275886115432 0.148562519196157 1.0 0.3759553763628191 89 Q6ZWJ1,P31751,O60830,P55786,Q14108,Q99523,O96008,Q9NS69,O00170,P27348,Q9Y4C2,Q7Z3T8,Q99595,O14925,O43464,Q8N4H5,Q5W0Z9,O00165,Q7Z6Z7,O95831 20 +Regulation of actin cytoskeleton reorganization 0.697609682340409 1.4419790453037593 0.1493082851410849 1.0 0.3769383435673627 8 O00165,Q9Y624,Q9UQB8 3 +Proteoglycan metabolic process 0.789672151042254 1.4406576019099722 0.1496814384567217 1.0 0.3769383435673627 3 Q8NCH0 1 +Proteoglycan biosynthetic process 0.789672151042254 1.4406576019099722 0.1496814384567217 1.0 0.3769383435673627 3 Q8NCH0 1 +Transmembrane receptor protein tyrosine kinase signaling pathway 0.4551135017343926 1.440507022019795 0.1497240047935115 1.0 0.3769383435673627 58 P11717,Q15375,Q99538,Q99523 4 +Toll like receptor signaling pathway 0.6362240239991586 1.4389780792679736 0.1501567335959353 1.0 0.3773530647959892 11 P09429,Q14254,O75955,Q06481,O00571 5 +Regulation of blood circulation 0.540653319707538 1.4379634886088923 0.1504444139878695 1.0 0.377921769450556 22 P10253,P42892 2 +Cellular response to potassium ion 0.7884913171857915 1.4360225872896475 0.150995914110289 1.0 0.3783808885539476 3 P55011 1 +Response to potassium ion 0.7884913171857915 1.4360225872896475 0.150995914110289 1.0 0.3783808885539476 3 P55011 1 +Regulation of pattern recognition receptor signaling pathway 0.5867128200758607 1.435646520168705 0.1511029501782461 1.0 0.378495062753239 16 O75179,O43657,Q06481,Q07021 4 +T cell mediated cytotoxicity 0.7836999673501736 1.4336566158881063 0.1516702784379524 1.0 0.3796072781879972 6 Q92692,Q9NUQ9,P01889 3 +Folic acid containing compound metabolic process 0.6069275422927157 1.4325243697126882 0.1519938088852623 1.0 0.3802624466910038 14 Q92820,Q9H2D1 2 +Antigen processing and presentation of peptide antigen via mhc class i 0.6347077450170666 1.432163921715535 0.1520969142548978 1.0 0.3803658412134061 11 P10321,P01889,Q9UIQ6 3 +Regulation of neural precursor cell proliferation 0.6341702552298104 1.429747741464351 0.1527894326283416 1.0 0.3811687749970419 11 Q06481 1 +Axo dendritic transport 0.5326600261488944 1.4286408977023914 0.1531074729859092 1.0 0.3814984666832225 23 P05067,Q00577,Q92572,Q14254,Q14203,Q9NUL3,O14617,Q9UH62 8 +Regulation of cell development 0.4316220103782376 1.426433262066787 0.1537433182094831 1.0 0.3821548688800112 70 P55209,Q07021,O94813,Q9UQB8,Q9Y624,Q15375,Q06481 7 +Protein localization to vacuole 0.6152231923332965 1.4257241465330923 0.1539479837014457 1.0 0.3825091749999197 13 Q14108 1 +Regulation of lipid catabolic process 0.77824466914867 1.4235141241367582 0.1545871706303165 1.0 0.3833467177375594 5 Q8WTV0,P31751 2 +Regulation of lymphocyte mediated immunity 0.5497575219815038 1.4234823394945368 0.1545963781293422 1.0 0.3833467177375594 20 Q92692,P11279,P02786 3 +Cytoplasmic translational initiation 0.5587247015715171 1.421715332257095 0.155108907298505 1.0 0.3844627786782992 19 Q04637,Q7Z478,Q15056,Q9ULC4,P42345,P55010,Q9NR50 7 +Locomotor rhythm 0.7846432913460009 1.4209149738234623 0.1553414793234631 1.0 0.3848843010843308 3 P54802 1 +Regulation of cation channel activity 0.6041124914809338 1.418915755170579 0.1559235784216679 1.0 0.3861711473621116 14 Q15334,P05067,P05556 3 +Multicellular organism reproduction 0.4172691916096507 1.4185430208677907 0.1560322877878517 1.0 0.3862850003658235 91 P05067,Q9BQE5,O94813,P07686,Q8NB78,P11717,P35613 7 +Positive regulation of defense response 0.5095577452596572 1.417059574612897 0.1564655103908265 1.0 0.3870462625457289 31 P05067,Q92692,Q9NUD5,P11279 4 +Regulation of developmental growth 0.4690999498252328 1.4141596509665473 0.157315032016736 1.0 0.3882572984263833 46 P05067,Q15375,Q99538,O43464 4 +Negative regulation of dna dependent dna replication 0.7816278949231716 1.4108169463030331 0.1582985963532204 1.0 0.389522626892873 4 Q9UNS1 1 +Epithelial tube morphogenesis 0.5200056642083283 1.410747830858622 0.1583189820473667 1.0 0.389522626892873 26 P11233,O94813,Q15375,Q9UNS1 4 +Cellular response to mineralocorticoid stimulus 0.7804081632653042 1.404282304674247 0.1602348014580918 1.0 0.3925848279257746 3 P20020,O95831 2 +Central nervous system development 0.4021294229648151 1.402479580180661 0.1607720840247062 1.0 0.3930020802985218 149 P05067,O95456,O75503,O94813,Q9UQB8,O14773,Q9BRK5,Q15375,P50897,P54802,Q92542,P04062,Q92688,Q06481 14 +Response to vitamin d 0.77990949782369 1.4023235669608904 0.1608186460037306 1.0 0.3930020802985218 3 Q13573 1 +Organic acid transmembrane transport 0.5345284675531612 1.402096780888346 0.1608863482341447 1.0 0.3930020802985218 22 O43772,P08195,P08183,Q9H2J7,Q9H2D1,P05556 6 +Potassium ion homeostasis 0.7792865912129832 1.40178461001335 0.1609795755258847 1.0 0.3930020802985218 4 P55011,P05026 2 +Potassium ion import across plasma membrane 0.7792865912129832 1.40178461001335 0.1609795755258847 1.0 0.3930020802985218 4 P55011,P05026 2 +Cellular potassium ion homeostasis 0.7792865912129832 1.40178461001335 0.1609795755258847 1.0 0.3930020802985218 4 P55011,P05026 2 +Macroautophagy 0.428607867995381 1.4015432748534191 0.1610516762738618 1.0 0.393022263503039 72 Q13501,Q96AX1,Q5MNZ6,O75436,Q86Y82,O95721,Q9Y3E7,Q9Y487,P51809,O15118,P04062,O15269,O43464,Q93050,Q9Y263 15 +Dendrite development 0.4815619084217987 1.400433051243118 0.161383678443862 1.0 0.3932140877457712 38 P05067,Q13177,Q06787,O96013,Q9UQB8,Q96HC4,Q9NUL3,Q66K74,Q15334,P05556 10 +Response to abiotic stimulus 0.4078161915527643 1.399642148147696 0.1616205058148834 1.0 0.3932140877457712 170 P05067,Q99538,P02786,P58546,P31751,P54132,P55786,Q06481,P61421,Q15904,P05026,Q06787,Q9Y487,O60884,Q70UQ0,Q13217,Q9H1E3,P05556,P30519,P55011,Q9ULM6,O75844,Q9BRK5,Q9Y624,P04062,Q9UNS1,P20020,Q9NR50,P38398,Q9C0C2,Q9NXR7,Q99543,P08183,O43464,O95831 35 +N terminal protein amino acid modification 0.6861045437471427 1.3946925953306482 0.1631085587632708 1.0 0.3949337950360361 8 Q9BV86 1 +Myoblast fusion 0.7730212874433792 1.3937146113867147 0.1634038021611812 1.0 0.3951736736111397 6 P35579,O75955,Q9H4M9,P05556 4 +Syncytium formation 0.7730212874433792 1.3937146113867147 0.1634038021611812 1.0 0.3951736736111397 6 P35579,O75955,Q9H4M9,P05556 4 +Regulation of amyloid beta clearance 0.7775510204081615 1.3930587379831127 0.1636020292406683 1.0 0.3951736736111397 3 P30533,Q13547 2 +Mitochondrial transport 0.4280439619609267 1.392336380913471 0.1638205596099375 1.0 0.395391291853542 70 O43772,Q99595,Q7Z6Z7,O95831,Q14849,Q96EK5,O14925,O96008,O43464,O60830,P55786,Q8N4H5,O00170 13 +Transport along microtubule 0.4689478622678582 1.3915493799261962 0.1640588966206022 1.0 0.395811374017652 43 P05067,Q00577,P11279,Q14254,Q9BW83,Q9UH62,Q9Y678,Q14203,Q9NUL3,O14617,Q66K74,Q5SNT2 12 +Organic acid transport 0.4994732196395461 1.3905103886292494 0.16437394689729 1.0 0.3962609205350879 33 P55011,O43772,P08195,P31751,P08183,O43808,Q9H2J7,Q9H2D1,P05556 9 +Regulation of cell shape 0.5149050744492715 1.389946020553297 0.1645452694554832 1.0 0.3965186786839178 27 P07686,Q9UQB8 2 +Cellular response to leucine 0.6911464708282399 1.3895656254057267 0.1646608200640824 1.0 0.3966418893327682 2 P42345 1 +Microtubule based transport 0.4674425086643725 1.3862956722907032 0.165656637798172 1.0 0.3987286625970858 44 P05067,Q00577,P11279,Q14254,Q9BW83,Q9UH62,Q9Y678,Q14203,Q9NUL3,O14617,Q66K74,Q5SNT2 12 +Neuron differentiation 0.4059173131604178 1.38375154370362 0.1664345449431092 1.0 0.3995162567787664 167 P05067,Q9H4M9,O75503,Q02880,P58546,P42892,P50897,Q14108,Q9Y263,Q06481,Q13547,Q8WUJ1,Q06787,O94813,Q96G23,Q96HC4,Q15375,P54802,Q66K74,P05556,Q9UQB8,P04062,Q15334,P84095,O60701,O43464,P35613,Q99873 28 +Multivesicular body sorting pathway 0.7677685595969876 1.3835315630667204 0.1665019362615738 1.0 0.3995162567787664 5 Q99523 1 +Endosome transport via multivesicular body sorting pathway 0.7677685595969876 1.3835315630667204 0.1665019362615738 1.0 0.3995162567787664 5 Q99523 1 +Toll like receptor 3 signaling pathway 0.7750174722762619 1.383104798170799 0.1666327346772571 1.0 0.3995162567787664 3 O75955 1 +Regulation of heterotypic cell cell adhesion 0.7750174722762619 1.383104798170799 0.1666327346772571 1.0 0.3995162567787664 3 O75955 1 +Regulation of toll like receptor 3 signaling pathway 0.7750174722762619 1.383104798170799 0.1666327346772571 1.0 0.3995162567787664 3 O75955 1 +Regulation of lipid kinase activity 0.7745370596863378 1.3812171826517603 0.1672121931282568 1.0 0.4002820657428761 3 A4D1P6 1 +Tissue migration 0.4696232033162896 1.3806600801769664 0.1673835009570485 1.0 0.4002883542098145 40 O94813,P67870,Q99538,Q8WTV0 4 +Regulation of fatty acid metabolic process 0.6406181997825753 1.3786211210272372 0.1680116009927759 1.0 0.4004829374032215 9 P38398,P31751,Q06481,O00763 4 +Leukotriene biosynthetic process 0.7737952549481528 1.378302433467529 0.1681099321956423 1.0 0.400562249430561 3 O14880 1 +Regulation of protein complex stability 0.7659976863258526 1.3767684669780214 0.1685838428986019 1.0 0.4007608960334719 5 Q13501 1 +Regulation of phospholipase activity 0.6812135368281598 1.3745582170984618 0.1692684498428072 1.0 0.4020778725625632 8 P50897 1 +Erk1 and erk2 cascade 0.5120785440704902 1.3720231806866765 0.1700562216729644 1.0 0.4033267168106479 27 P05067 1 +Cation transport 0.3864165127790325 1.371209975682688 0.1703095093454181 1.0 0.4037719095262762 119 P05067,P02786,Q13423,P13693,Q658P3,P61421,P05026,Q06787,P54709,P51790,Q9H2J7,P05556,P55011,O43772,Q9HD20,O75844,P51809,Q9UM00,Q15334,P08195,Q93034,Q8N4V1,O43808 23 +Negative regulation of dna replication 0.6387713256240082 1.3706278856055605 0.1704909855444007 1.0 0.4040465735168882 9 Q9UNS1 1 +Dna double strand break processing 0.7642789640935004 1.3702034533627527 0.1706234006168006 1.0 0.4042048009225245 5 P54132 1 +Maintenance of location 0.4559387537196178 1.36587746512833 0.171977426899786 1.0 0.4052296277925689 52 P10253,P17900,Q8WTV0,P07686 4 +Methionine metabolic process 0.7626801080717852 1.3640953833071623 0.1725375476101724 1.0 0.4059280399831226 5 Q13126 1 +Methionine biosynthetic process 0.7626801080717852 1.3640953833071623 0.1725375476101724 1.0 0.4059280399831226 5 Q13126 1 +Sulfur amino acid biosynthetic process 0.7626801080717852 1.3640953833071623 0.1725375476101724 1.0 0.4059280399831226 5 Q13126 1 +Establishment of protein localization 0.3266046588859352 1.363188817698698 0.1728230105437493 1.0 0.4064443376309644 401 P02786,P50897,O60830,Q5J8M3,Q14108,Q06481,P11279,Q15904,P10619,Q99523,O15118,A6NIH7,Q13501,Q99595,Q9UI26,Q8N4H5,Q5W0Z9,O75436,P11233,Q9H7B4,Q8N4V1,Q92688,O43464,O95831,O15127,Q8NC96,Q9Y282,P55786,O95373,Q658P3,Q8TEX9,Q99747,O00170,P27348,P55011,Q96AX1,Q9HD20,Q86Y82,P51809,O14925,Q03519,Q5SRE5,Q15334,Q12907,Q9BZH6,O95721,Q9Y3E7,P17858,Q7Z6Z7,Q9C0E2,Q9H4M9,P31751,Q9BVK6,P05026,O14828,Q9UID3,Q9NVZ3,Q9NPA8,Q969Q5,P24390,O96008,Q9NS69,Q9Y4C2,Q7Z3T8,P49069,Q6NUQ1,Q8NFH4,Q9BW83,Q9Y678,O00165,O43865,P35606,P50402,Q9H8Y8,Q96CS3,Q6ZWJ1,P61981,P55060,O00410 79 +Adiponectin activated signaling pathway 0.7698204553196607 1.3626828688513468 0.1729824791651828 1.0 0.4065745156943169 3 Q06481 1 +Sulfur amino acid metabolic process 0.719874753013855 1.3585301477878062 0.1742955230539866 1.0 0.4088972517890002 7 Q13126 1 +Plasma membrane raft organization 0.7687354025525802 1.358418619533987 0.1743308893854354 1.0 0.4088972517890002 3 O75955 1 +Plasma membrane raft assembly 0.7687354025525802 1.358418619533987 0.1743308893854354 1.0 0.4088972517890002 3 O75955 1 +Vesicle tethering 0.7683434792517169 1.3568783314955466 0.174819872889576 1.0 0.4096767703522996 3 Q14849 1 +Lymphocyte activation involved in immune response 0.5141422167971672 1.3568124192959552 0.1748408203518872 1.0 0.4096767703522996 24 P11279,P02786 2 +Muscle cell development 0.5111569815649388 1.3552908873653833 0.1753248971850807 1.0 0.4104469170983049 26 Q9NYL9,O75844,Q12802,Q96HC4,P42345,Q9H7B4,Q16527,P05556 8 +Regulation of long term neuronal synaptic plasticity 0.7602578547930504 1.354840144261803 0.1754684933486907 1.0 0.4105779339727364 5 P05067 1 +Dedifferentiation 0.6833945328437361 1.354696632240302 0.1755142313165896 1.0 0.4105779339727364 2 Q14103 1 +Negative regulation of transforming growth factor beta receptor signaling pathway 0.67592455484566 1.3527662761051442 0.1761303096638029 1.0 0.4117062705391172 8 Q92896 1 +Cytokine production 0.4228414739477671 1.3511281500017005 0.1766543854762747 1.0 0.4127745925531019 74 P05067,Q8IV08,Q9NUD5,P26583,Q06481,Q13546,P09429,O75955,P04439,P49755,Q9Y5K6,O00571,P01889,Q9Y624,P04062,O14802,O60828,P20020,P38398,Q07021,Q9NUQ9 21 +Ear development 0.5621505564037642 1.3493373967898108 0.1772286189631993 1.0 0.4134886725867442 17 P42892,P54802 2 +Glycoprotein metabolic process 0.4738790686655391 1.3436453268260793 0.1790631047608499 1.0 0.4167659200635731 38 Q10472,O15118,Q10471,Q92542,O43505,Q8NCH0 6 +S adenosylmethionine cycle 0.764227083707312 1.3406997848747335 0.1800179444442662 1.0 0.4184109037158728 3 Q9BV20 1 +Positive regulation of mitochondrial fission 0.7631558695948168 1.339512312132075 0.1804039489975988 1.0 0.4189917442392364 4 P11233,Q96HS1 2 +Regulation of leukocyte degranulation 0.7624575640386089 1.3368152816287162 0.1812829397231903 1.0 0.4206137716646188 4 P11279 1 +Erbb signaling pathway 0.5667335816523995 1.3335848920819655 0.1823399369512328 1.0 0.4219613659195493 16 Q93034,Q99538 2 +Regulation of histone h4 k16 acetylation 0.7617335750776996 1.3308991756232502 0.1832221885464826 1.0 0.422266714415154 3 P38398 1 +Regulation of myoblast fusion 0.7609005928886244 1.3308016357896313 0.1832542895756523 1.0 0.422266714415154 4 O75955,Q9H4M9 2 +Regulation of syncytium formation by plasma membrane fusion 0.7609005928886244 1.3308016357896313 0.1832542895756523 1.0 0.422266714415154 4 O75955,Q9H4M9 2 +Positive regulation of myoblast fusion 0.7609005928886244 1.3308016357896313 0.1832542895756523 1.0 0.422266714415154 4 O75955,Q9H4M9 2 +Positive regulation of syncytium formation by plasma membrane fusion 0.7609005928886244 1.3308016357896313 0.1832542895756523 1.0 0.422266714415154 4 O75955,Q9H4M9 2 +Regulation of leukocyte mediated immunity 0.5070790220389589 1.3296691299035124 0.1836273101795278 1.0 0.4229679568931361 26 Q92692,P11279,P51809,P02786 4 +Positive regulation of cell junction assembly 0.6691785018997052 1.3249447940510837 0.1851894623404439 1.0 0.4253545898217947 8 Q9NUL3,Q96AC1,P60903,O75955 4 +Response to ischemia 0.6279886312398716 1.3239029049129138 0.1855352933479972 1.0 0.4257699594273645 9 Q13501 1 +Growth 0.3894113918448962 1.3221320151870208 0.1861241945993665 1.0 0.4268032276157542 133 P05067,Q9BZH6,Q7Z4V5,Q12802,O94813,Q15056,Q99538,P02786,Q9ULC4,Q15375,P50897,P05556,O43464,Q5BJF2,Q9Y263 15 +Negative regulation of lymphocyte mediated immunity 0.7582094489456059 1.317047708783076 0.1878226332083072 1.0 0.4294184748100809 3 P01889 1 +Positive regulation of filopodium assembly 0.7571235626697017 1.3162121559185254 0.1881028448268713 1.0 0.4295788335309539 4 P11233 1 +Dendritic cell chemotaxis 0.75783723209728 1.3155847398959726 0.18831345820682 1.0 0.4295788335309539 3 Q07021 1 +Positive regulation of transport 0.384532850093589 1.3150433941081796 0.1884953189683313 1.0 0.4296582886928629 124 Q9C0E2,Q9H4M9,O00410,P31751,P50897,Q9Y282,P55786,Q9Y263,Q06481,P11279,P05026,Q16630,Q06787,O75955,P49755,Q9Y5K6,P54709,P05556,P55011,Q9Y4C2,P51809,Q03164,O43464,P20020,Q12907,O43865,P08183,Q92688,Q7Z6Z7,P50402 30 +Regulation of t cell mediated immunity 0.7084951624505385 1.3138124711491177 0.1889093197402904 1.0 0.4300624350968677 7 P09429,Q9NUQ9,P01889,Q92692 4 +Cell projection organization 0.4046723377055931 1.3122000011356996 0.189452661487069 1.0 0.4300624350968677 193 Q8N0X7,P05067,Q13177,Q4KMP7,Q9H4M9,O96013,Q92692,Q02880,Q99538,Q9UHB6,P42892,O15439,Q15555,Q14108,Q9Y263,Q06481,P61421,P09429,O75955,Q06787,O94813,Q96G23,Q9NQW6,Q96HC4,Q9Y5K6,Q15375,Q66K74,A6NIH7,P05556,Q9UQB8,Q14203,P04062,P51114,Q15334,Q9BW83,Q9BZH6,P11233,O95721,P42345,P84095,Q15428,P35613,Q99873 43 +Protein polyubiquitination 0.4606159323149537 1.3117065482255692 0.1896191664957804 1.0 0.4300624350968677 40 Q9UIQ6,P49427,Q16763,P55786,Q9Y263,P38398 6 +Ion transport 0.3966092532075672 1.3103266451919335 0.1900853572788914 1.0 0.4300624350968677 154 P05067,Q9C0H2,P02786,Q13423,O15439,P13693,Q8TB61,Q658P3,P61421,P05026,Q06787,P54709,O96008,P51790,Q9H2J7,P05556,P55011,Q9Y4C2,O43772,Q9HD20,O75844,Q9UHG3,P51809,Q9UM00,Q9H2D1,Q15334,P08195,Q93034,Q8N4V1,P08183,O43808 31 +Neurogenesis 0.4051023239829009 1.3101615022371795 0.1901412062092373 1.0 0.4300624350968677 206 P55209,P05067,Q8N0X7,Q13177,Q9H4M9,O75503,P61981,O96013,Q02880,P26583,P58546,P42892,P50897,P31751,Q13573,Q15555,Q14108,Q9Y263,Q06481,Q13547,P09429,Q8WUJ1,Q06787,O94813,P07686,Q96G23,Q96HC4,Q15375,P54802,Q92542,O14949,Q66K74,P05556,Q9ULM6,Q9UQB8,P04062,Q15334,Q9NR50,Q96P11,Q9BW83,P42345,P84095,O60701,O43464,Q15428,P35613,Q99873 47 +Negative regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway 0.7554589433991372 1.3097819125141494 0.1902696237134753 1.0 0.4300624350968677 4 O43657 1 +Organic hydroxy compound biosynthetic process 0.4772501590675144 1.3090688022833246 0.1905110459185737 1.0 0.4304500953103333 36 Q9UBM7,Q15392,P04062,O15269,Q13510 5 +Mitotic spindle midzone assembly 0.7559183673469365 1.3080429102113842 0.190858755394319 1.0 0.4308790770170993 3 Q02241,O43663 2 +Developmental maturation 0.4807046617431567 1.3074836340343847 0.1910485096180083 1.0 0.4308790770170993 35 P05067,P04062,P51790,O75503 4 +Sulfur compound biosynthetic process 0.4873732950587083 1.3074768358449798 0.1910508169979992 1.0 0.4308790770170993 33 Q13126,Q9BV20,O00763,P50897,O60701,O43505,Q92947,Q8TB61,Q8NCH0 9 +Regulation of atp metabolic process 0.523510638325273 1.3045724196363462 0.19203848481092 1.0 0.4327680329258814 21 P05067 1 +Response to interferon beta 0.7468628746359622 1.303632264890784 0.1923589942407793 1.0 0.4327811740519621 5 P49427 1 +Cellular response to interferon beta 0.7468628746359622 1.303632264890784 0.1923589942407793 1.0 0.4327811740519621 5 P49427 1 +Negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway 0.6061209944169211 1.3032045575622488 0.1925049345978693 1.0 0.4327811740519621 11 Q9Y2U8,Q92896 2 +Regulation of potassium ion transmembrane transporter activity 0.6638864851044832 1.3031020301666467 0.1925399306210296 1.0 0.4327811740519621 8 P05026,P05556 2 +Bone development 0.5369303894106543 1.3018509831271987 0.1929673314484516 1.0 0.433138847877549 19 Q15904,Q92896 2 +Cap dependent translational initiation 0.6707466340269319 1.2978118259820046 0.1943520048750331 1.0 0.4352755529781236 2 Q04637 1 +Magnesium ion transport 0.7531052563378412 1.296986893121283 0.1946356965848477 1.0 0.4355622401638312 3 Q8N4V1 1 +Retrograde transport endosome to golgi 0.5018637826325683 1.296847514490223 0.1946836584263218 1.0 0.4355622401638312 26 O75436,Q4KMP7,Q5VIR6,O75503,Q9UID3,Q14203,P40616,Q9BVK6 8 +Regulation of mitotic centrosome separation 0.7526530612244877 1.2952097647478764 0.195247877201903 1.0 0.4366658844649899 3 P43487,Q9UNZ2 2 +Regulation of transmembrane transport 0.445983914921041 1.294481874578116 0.1954990261005746 1.0 0.4370688103490335 53 Q9Y4C2,P05067,Q6ZWJ1,P05026,Q06787,O75844,P54709,O43865,P31751,P08183,P05556,Q15334,Q06481 13 +Peptidyl serine modification 0.4508832626566817 1.2937077398432928 0.1957663908726643 1.0 0.4373489363581257 49 P05067,Q10472,Q9C0C2,Q13177,P48729,P02786,P42345,O00165,Q9H7B4,Q10471,P31751,Q13610,Q9BV86 13 +Positive regulation of protein phosphorylation 0.4168949141510875 1.290548200505541 0.1968603877153805 1.0 0.4394740417561993 73 Q13501,P05067,Q9C0C2,Q13177,Q96A49,Q06787,Q12802,P67870,P02786,P42345,O00165,Q9H7B4,Q15375,P31751,P51114,Q96AC1,Q15334,Q13546 18 +Inorganic anion transmembrane transport 0.745180393693937 1.2893542091626036 0.1972749729869036 1.0 0.4400277549068227 6 P55011,P51790 2 +Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 0.5863825718558116 1.2892165163299787 0.1973228246382552 1.0 0.4400277549068227 13 Q8IXB1,O95831 2 +Positive regulation of locomotion 0.4424436381781689 1.2889589726266997 0.1974123502250033 1.0 0.4400680088107696 55 P05067,Q8WTV0,Q07021,O94813,Q99538,P05556,Q9Y263 7 +Dna damage response signal transduction resulting in transcription 0.6682986536107715 1.2868059272773444 0.1981619404815227 1.0 0.441579105155532 2 Q9UNS2 1 +Sarcomere organization 0.6591643535980544 1.2836001131043824 0.1992819101633332 1.0 0.4435931745754311 8 Q16527,P05556 2 +Positive regulation of hydrolase activity 0.4155754615749187 1.2831434067665268 0.1994418388029701 1.0 0.443788724795767 75 P05067,Q4KMP7,Q99538,Q9Y624,Q92542,O43464,Q92688,O95831,Q9Y263 9 +Response to chemokine 0.7434487098379464 1.282856017401458 0.1995425243725135 1.0 0.4438523564167506 6 P55011,O94813 2 +Endocytic recycling 0.5566020402282912 1.2816124900358148 0.1999786165416477 1.0 0.4443407946759022 16 O75436,Q15904,Q9H4M9 3 +Amino acid transmembrane transport 0.6007790677503095 1.27901946178883 0.2008902026024861 1.0 0.4458835535052297 11 Q9H2J7,P08195 2 +Regulation of filopodium assembly 0.6169446911463683 1.2759585147646335 0.2019701844029857 1.0 0.4477963361070159 9 P11233,P51114,Q06787 3 +Lipid metabolic process 0.4023161642323969 1.2740300035965502 0.2026527831033593 1.0 0.4489863927914297 200 P05067,Q9HB40,Q8NHP8,P06280,Q99538,P61916,P17900,P50897,Q06481,P16278,P06865,Q99519,Q8WTV0,P07686,O14773,O15118,P38571,Q13510,P35790,Q9UBM7,Q14849,Q15392,P04062,Q86UY6,O15269,Q14739 26 +Regulation of anion transport 0.6075929388807632 1.271464701430199 0.2035633774003566 1.0 0.4505175106592365 10 P55011,Q9Y4C2,O43865,P08183,P05556 5 +Regulation of cardiac conduction 0.7380703270705489 1.270004590567063 0.20408299495917 1.0 0.4506320839453074 5 P23634,P20020,Q6PI78 3 +B cell activation involved in immune response 0.5640071484156637 1.2694571343609369 0.2042780697237403 1.0 0.4506320839453074 15 P02786 1 +Somatic diversification of immunoglobulins involved in immune response 0.5640071484156637 1.2694571343609369 0.2042780697237403 1.0 0.4506320839453074 15 P02786 1 +Immunoglobulin production involved in immunoglobulin mediated immune response 0.5640071484156637 1.2694571343609369 0.2042780697237403 1.0 0.4506320839453074 15 P02786 1 +Rna phosphodiester bond hydrolysis endonucleolytic 0.4988005321254165 1.2691533219255904 0.2043863855514907 1.0 0.4506320839453074 25 O00584 1 +Regulation of neurogenesis 0.4497042549349199 1.2673622797749784 0.205025780758447 1.0 0.4506320839453074 47 P55209,O94813,Q9UQB8,Q15375,Q06481 5 +Lipoprotein metabolic process 0.563050042255005 1.264669455428097 0.2059898437205309 1.0 0.4520431242586022 15 Q5W0Z9,P04062,P50897,Q9BQE5 4 +Magnesium ion homeostasis 0.6621787025703865 1.2593013231368038 0.207921515512278 1.0 0.455415429032051 2 Q6P4Q7 1 +Positive regulation of nf kappab transcription factor activity 0.5156170425578424 1.25892104276316 0.2080588524040638 1.0 0.4555541800326533 21 P05067 1 +Import across plasma membrane 0.5707408775457541 1.256805139407639 0.2088242045862407 1.0 0.4569960667966188 14 P55011,P05026,P08195,P31751,P05556 5 +Regulation of systemic arterial blood pressure 0.7364769044127811 1.2566902149998165 0.2088658327051624 1.0 0.4569960667966188 6 P42892 1 +Interleukin 6 production 0.6039920171113426 1.2554867863299273 0.2093021019156475 1.0 0.4573005825034216 10 P05067,P04062 2 +Sphingolipid biosynthetic process 0.5953245093497618 1.254302920393545 0.2097319228602434 1.0 0.4580771369459095 11 P04062,O15269,Q13510 3 +Regulation of macroautophagy 0.4574988454627721 1.2535044392454546 0.2100221845230332 1.0 0.4583858880213809 39 O75436,O15118,P04062,Q93050,O15269 5 +Cell junction organization 0.3934325250457875 1.2515387610756414 0.2107379811949383 1.0 0.4592969027317647 98 P05067,Q14126,Q9UQB8,Q99538,Q9BRK5,Q15375 6 +Pattern recognition receptor signaling pathway 0.4969715253390263 1.251054251441693 0.2109146849261254 1.0 0.4594904912392127 24 O43657,Q06481,O75179,Q07021 4 +Positive regulation of phosphorus metabolic process 0.3959430502418717 1.2507326672054753 0.2110320278881023 1.0 0.4594904912392127 96 P05067,Q14738,Q13177,P02786,P31751,Q96AC1,Q13546,Q05639,Q15185,Q06787,Q15375,Q13501,Q96A49,Q12802,P04062,P51114,Q15334,Q9C0C2,P67870,P42345,O00165,Q9H7B4 22 +Positive regulation of mitotic cell cycle 0.465063497994429 1.248518108479311 0.2118413810791299 1.0 0.460886001167563 37 P05067,O75179,Q99538 3 +Notch signaling pathway 0.5678831338554564 1.242868610800864 0.2139162542777584 1.0 0.4639247543459522 14 P05067 1 +Somatic diversification of immunoglobulins 0.5259978957506101 1.2414383467798908 0.2144438605966598 1.0 0.4649052287653644 19 P02786 1 +Positive regulation of blood brain barrier permeability 0.7387755102040794 1.2406903301345458 0.2147201678669787 1.0 0.4650130402944032 3 Q9UDY2,Q16625 2 +Regulation of blood brain barrier permeability 0.7387755102040794 1.2406903301345458 0.2147201678669787 1.0 0.4650130402944032 3 Q9UDY2,Q16625 2 +Positive regulation of vascular permeability 0.7387755102040794 1.2406903301345458 0.2147201678669787 1.0 0.4650130402944032 3 Q9UDY2,Q16625 2 +Brain morphogenesis 0.7371555395176637 1.2390844959541405 0.2153142080383769 1.0 0.4658080038272266 4 P04062 1 +Regulation of nervous system development 0.4427854145640676 1.2367107985046053 0.2161944682894045 1.0 0.4673611311930249 50 P55209,Q13547,Q8N0X7,Q96P11,O94813,Q96G23,Q9UQB8,P42345,Q15375,Q13573,Q06481 11 +Response to alcohol 0.4866844694583132 1.2336136078241533 0.217346919880804 1.0 0.4692163343990569 29 O94813,Q9BRK5,P54132,O95831,P16278 5 +Glial cell differentiation 0.4765564820512748 1.232935720862678 0.2175997470195201 1.0 0.4694670253296207 33 Q13547,P05067,Q96P11,P04062,P31751,Q92542,Q9NR50 7 +Neuron cellular homeostasis 0.72836705226414 1.2328933905196122 0.2176155417071199 1.0 0.4694670253296207 5 Q14203,P51790 2 +Dendritic cell migration 0.7352782292319766 1.2318360809961393 0.2180103222510805 1.0 0.4701539594045194 4 Q07021 1 +Sperm dna condensation 0.6556507547939628 1.2299842794453053 0.2187029917975635 1.0 0.4714826052162461 2 Q14997 1 +Receptor internalization 0.53160690100225 1.228429568577674 0.2192857537207448 1.0 0.4719807122167826 18 O75955,Q06787,P02786,P30533,P05556,Q96CW1,Q15334 7 +Metencephalon development 0.4909117944317688 1.2277448991739834 0.2195427458938763 1.0 0.4723007290246669 26 P54802,Q92542,Q9BRK5 3 +Cytosolic transport 0.4464570662025535 1.2273394496061334 0.2196950341659349 1.0 0.4724632641843037 45 O75436,P11279,Q99523,O75503 4 +Regulation of supramolecular fiber organization 0.4081671902611862 1.2253877628780503 0.2204291553724064 1.0 0.4735458163391161 79 P05067,Q13177,Q13045,Q9UHB6,P58546,Q96AC1,Q9NYL9,O94813,Q66K74,Q12802,Q9UQB8,Q14203,Q9UHV9,Q9Y624,O15143,Q99471,Q14019,Q15691,P42345,Q16625,O00165,Q9NUQ9 22 +Regulation of bicellular tight junction assembly 0.7258840585870228 1.2233983983437386 0.221179258018759 1.0 0.4746604014017077 5 Q9Y624,P17612,O75116 3 +Ceramide biosynthetic process 0.7272589028900043 1.2220905322740248 0.2216733930401568 1.0 0.4749325241038537 6 P04062,O15269,Q13510 3 +Response to metal ion 0.4428000032348264 1.2195185323157574 0.2226474463145134 1.0 0.4764825606390194 48 O60888,P05067,Q99538,P02786,O15118 5 +Neural retina development 0.6843080772304115 1.218632107201398 0.2229838571017319 1.0 0.4766410563570302 7 P20020,P54802 2 +Amino acid import 0.6842441931856034 1.2183806032214517 0.2230793726070863 1.0 0.4766410563570302 7 P08195 1 +Leukocyte degranulation 0.7262602752418855 1.2183423423479038 0.223093905784073 1.0 0.4766410563570302 6 P11279 1 +Nucleotide transport 0.5796482881459148 1.2183037131049967 0.2231085795713758 1.0 0.4766410563570302 12 Q9H2D1,O15439,O43808,Q9BSK2 4 +Autophagosome maturation 0.5873333630965867 1.218059586737847 0.2232013299118016 1.0 0.4766738079316555 11 O95721,Q96AX1,P51809 3 +Positive regulation of toll like receptor signaling pathway 0.7243216388170934 1.2174242206623065 0.2234428523337188 1.0 0.4770241476486501 5 P09429,O75955,O00571 3 +Fibroblast migration 0.562357080188907 1.215902122937922 0.224022209295057 1.0 0.4779295712507505 14 Q06481,P05556 2 +Regulation of cellular ketone metabolic process 0.5783830270709104 1.2124255024680075 0.2253495436633867 1.0 0.4797051717781023 12 P38398,P31751,Q06481,O00763 4 +Regulation of mitochondrion organization 0.4601307326777398 1.212372287547555 0.2253699040651358 1.0 0.4797051717781023 37 Q13501,Q9UG56,P11233,P02786,O00165,Q96HS1,O43464,Q7Z6Z7,Q9Y6C9 9 +Anatomical structure maturation 0.4896747508291068 1.2121561438717494 0.225452615655048 1.0 0.4797051717781023 25 P05067,P04062,O75503 3 +Positive regulation of b cell mediated immunity 0.5939397275325303 1.210849031290133 0.2259532696672646 1.0 0.4800724223572834 10 P02786 1 +Negative regulation of cell projection organization 0.4960065333738883 1.2080504692971763 0.227027849960494 1.0 0.481383663002867 23 O94813,Q15375 2 +Natural killer cell activation 0.7206713493872752 1.2034687038842873 0.2287949951181858 1.0 0.4835876364375798 5 P11279 1 +Regulation of axonogenesis 0.5056424837217436 1.2011048318861532 0.2297105389548428 1.0 0.4846908116329566 21 O94813 1 +Apoptotic cell clearance 0.6788952783155433 1.1973227580282109 0.2311807773251488 1.0 0.4868342958485422 7 P84095,Q8WTV0 2 +Protein import 0.4076051483984249 1.1963284480166465 0.2315684114602654 1.0 0.4868342958485422 70 Q13501,Q8TEX9,Q99595,Q9UI26,O14925,O60830,O95373,O95831,Q06481 9 +Regulation of amino acid transport 0.7186257201853101 1.1956494497738617 0.2318333856468939 1.0 0.4868342958485422 5 P05556 1 +Amine transport 0.7186257201853101 1.1956494497738617 0.2318333856468939 1.0 0.4868342958485422 5 P05556 1 +Divalent inorganic cation homeostasis 0.4434856090641642 1.1924890939788084 0.2330695245404743 1.0 0.4881303831874182 43 P05067,P09429,Q6P4Q7,Q9ULM6,P05026,Q9HD20,P07686,Q9UM00,O14617,P20020,P13693,Q15334 12 +Regulation of wound healing spreading of epidermal cells 0.7247856267864397 1.1913434950903798 0.2335187654405657 1.0 0.4882088417037705 4 Q96AC1,P42345,Q7Z460 3 +Basement membrane organization 0.7247856267864352 1.191343495090363 0.2335187654405723 1.0 0.4882088417037705 4 O60568,P05556,Q7Z460 3 +Negative regulation of fatty acid metabolic process 0.7169880201690367 1.1893903417744252 0.234286099651237 1.0 0.4893838744540023 5 Q06481 1 +Hormone metabolic process 0.4984156736865754 1.1890963907898024 0.2344017384802774 1.0 0.4893838744540023 22 Q9HB40,P42892,Q9UBM7 3 +Retina development in camera type eye 0.5731613438088163 1.188158686219543 0.2347708969068302 1.0 0.4893838744540023 12 P20020,Q99471,P54802 3 +Response to amphetamine 0.6462668298653643 1.1878939799336845 0.234875181769677 1.0 0.4893838744540023 2 Q92769 1 +Imp salvage 0.6462668298653625 1.187893979933677 0.2348751817696799 1.0 0.4893838744540023 2 P07741 1 +Guanine metabolic process 0.6462668298653627 1.187893979933677 0.2348751817696799 1.0 0.4893838744540023 2 O60341 1 +Regulation of actomyosin structure organization 0.5314542775271214 1.1878928031696214 0.23487564544609 1.0 0.4893838744540023 17 Q07157,Q13177,Q12802,Q7Z460,P42345,Q9Y624,P60903,O75116,Q96AC1,P63167 10 +Regulation of anion transmembrane transport 0.7178278041135286 1.1866971684864125 0.2353470923190617 1.0 0.4902002866740402 6 Q9Y4C2,P08183,P05556 3 +Organelle fusion 0.4774123284996003 1.1864779394027734 0.2354336084484689 1.0 0.4902137886892593 30 Q86Y82,O95721,Q9Y3E7,P51809,P02786,Q8IWA4,P31751,Q7Z6Z7 8 +Regulation of fibroblast migration 0.6760894370753545 1.1862772887185689 0.2355128125617718 1.0 0.4902137886892593 7 Q06481 1 +Basement membrane assembly 0.7244897959183652 1.1846389858828417 0.2361602157872986 1.0 0.4908968033921554 3 O60568,Q7Z460 2 +Response to calcium ion 0.5233072576441047 1.183594879458134 0.2365734683397138 1.0 0.4910178345137697 18 Q99538 1 +Amyloid beta formation 0.6349479556487297 1.1834853604922766 0.236616845054792 1.0 0.4910178345137697 8 Q92542,P49755,O75116,P27695 4 +Tail anchored membrane protein insertion into er membrane 0.5875772104730121 1.1825772863775208 0.2369767187432256 1.0 0.4911957621956367 10 Q5J8M3 1 +Histone h4 deacetylation 0.7151754382018124 1.1824638520547952 0.2370217004195609 1.0 0.4911957621956367 5 Q13547,Q9H4L7 2 +Cellular response to acid chemical 0.5787923390426573 1.179290483403986 0.2382825264170824 1.0 0.4928134078434588 11 Q9UQB8,P42345,P17655,Q99729,O00410,Q14103,Q6IAA8,P26358 8 +Meiotic spindle organization 0.6434108527131837 1.1750993691453928 0.2399549630320141 1.0 0.4957727206000372 2 P35579 1 +Negative regulation of lipid metabolic process 0.6323727663550419 1.1728353083534977 0.2408618559327919 1.0 0.4971637735474837 8 Q06481 1 +Embryo implantation 0.593046331588429 1.1720199085557557 0.2411890632447493 1.0 0.4976545115274536 9 P35613,Q07021 2 +Regulation of fatty acid oxidation 0.7185424560291492 1.1672718324895413 0.2431006100484656 1.0 0.5007596039037815 4 P31751,Q06481 2 +Regulation of peptidyl tyrosine phosphorylation 0.4993467380859027 1.1645523225980958 0.2442002523526558 1.0 0.5026883830609502 21 P05067 1 +Negative regulation of cellular senescence 0.6405548755609974 1.1623131979056895 0.2451082675662927 1.0 0.5035848513675075 2 Q00534 1 +Immune response 0.3903897473237795 1.16197348836671 0.2452462340838628 1.0 0.5035848513675075 173 P05067,O00584,Q92692,Q9NUD5,P02786,O95373,Q06481,P11279,Q8IWZ3,Q9Y487,O43657,Q9ULM6,P10321,Q9UQ84,Q7Z739,P51809,P01889,O75179,Q07021,Q12899 20 +Sodium ion export across plasma membrane 0.7183053883754241 1.160409546632847 0.2458821017557042 1.0 0.5044638788769981 3 P05026 1 +Neural precursor cell proliferation 0.4984995285262059 1.1596306229330728 0.2461992275276898 1.0 0.504946250462354 21 O95456,Q06481 2 +Immunoglobulin production 0.493289611658131 1.1587030856766447 0.2465772326414317 1.0 0.5053848273546255 22 P02786 1 +Positive regulation of mitochondrial translation 0.708652243861632 1.1575467500989172 0.247049050634309 1.0 0.5059809341440592 5 Q567V2 1 +Positive regulation of actin cytoskeleton reorganization 0.7149169496144029 1.1533026656450258 0.2487861764044225 1.0 0.5082204671937723 4 Q9UQB8 1 +Negative regulation of response to cytokine stimulus 0.7082034728861671 1.1505981440341555 0.2498975968994368 1.0 0.5094766569900107 6 O94813 1 +Anterior head development 0.6364749082007363 1.1440633064314043 0.252597383708079 1.0 0.5144697623191011 2 O15067 1 +Regulation of cellular response to growth factor stimulus 0.4784280162953306 1.1417436520693798 0.2535605903847071 1.0 0.5161103667474807 25 O94813 1 +Positive regulation of oligodendrocyte differentiation 0.7118025181923122 1.1413091874978998 0.2537412801883456 1.0 0.5161377754262668 4 Q13547,P42345 2 +Positive regulation of immune response 0.4170130352718744 1.1372534012133138 0.2554323688355073 1.0 0.5173345706974404 60 P11279,Q07021,Q92692,Q9NUD5,P51809,P02786,Q06481 7 +Antigen processing and presentation via mhc class ib 0.7123262652427327 1.1370111678207466 0.2555336170858542 1.0 0.5173694443925039 3 Q03519 1 +Nucleoside monophosphate phosphorylation 0.7026988794078552 1.134823397746818 0.2564493206950495 1.0 0.5183224718974326 5 Q9Y3D8,P23919 2 +Regulation of glucose transmembrane transport 0.6629324353935651 1.1345030201458393 0.2565836076080694 1.0 0.5183224718974326 7 Q6ZWJ1,P31751,Q06481 3 +Regulation of mitochondrial gene expression 0.5842537718443926 1.1337566579030756 0.2568966361800249 1.0 0.5184243162767661 9 Q567V2 1 +Positive regulation of translational initiation 0.5764636967826787 1.1331800388698108 0.2571386549287049 1.0 0.5186111157420855 10 Q13217,Q7Z739,O00571,P42345 4 +Response to actinomycin d 0.63402692778458 1.1331232387173562 0.2571625036675882 1.0 0.5186111157420855 2 P04637 1 +Negative regulation of actin filament bundle assembly 0.6226511714206209 1.1326379774882738 0.2573663133800798 1.0 0.5186921085044687 8 Q07157,Q13177,Q7Z460,Q9Y624,P63167 5 +Peptidyl proline hydroxylation to 4 hydroxy l proline 0.7013699807816871 1.129753775924785 0.2585799906241859 1.0 0.5205237134280173 5 P13674,O15460 2 +Blood vessel endothelial cell migration 0.5055156192788939 1.1279063308561903 0.2593594799238214 1.0 0.521173732993136 19 P42785,O94813,P67870,Q8WTV0 4 +Response to increased oxygen levels 0.6609763448717498 1.1268099855464924 0.2598228277117655 1.0 0.521375301097567 7 Q15904,Q9Y487 2 +Regulation of membrane potential 0.4283208433558619 1.1264670740054936 0.2599678698017753 1.0 0.521375301097567 51 P05067,P05026,Q06787,Q9BSK2,O75844,Q14126,Q9UQB8,P42345,P54709,P04062,P31751,Q8IWA4,Q15334 13 +Lysosomal protein catabolic process 0.707631139346159 1.1252559699121902 0.2604805817980438 1.0 0.5215541275221319 4 O14773 1 +Protein catabolic process in the vacuole 0.707631139346159 1.1252559699121902 0.2604805817980438 1.0 0.5215541275221319 4 O14773 1 +Positive regulation of sodium ion transport 0.6604773277768861 1.1248476642631435 0.2606535925750506 1.0 0.521730874344794 7 Q9UHD1,P05026,P54709,O43865,O43707 5 +Muscle structure development 0.3976635402114132 1.1240187608666563 0.261005067105259 1.0 0.5220949311783886 80 Q13045,Q9H4M9,Q8IV08,P58546,Q13547,Q9NYL9,O75955,Q7Z4V5,Q99523,Q96HC4,P05556,Q14254,Q12802,O75844,P51114,Q96PU8,P35579,Q16527,O75179,P42345,Q9H7B4,P50402,Q14331 23 +Positive regulation of protein localization to membrane 0.4870315083297028 1.1215658543324978 0.2620470766377822 1.0 0.523329176405717 22 Q13501,Q14651,Q9Y4C2,O15258,O00264,P84095,P31751,Q15334,P05556 9 +Interleukin 12 production 0.7061672532245526 1.1196254121447855 0.2628734218004829 1.0 0.5246391111914338 4 P01889,Q07021 2 +Cellular response to ether 0.6303549571603442 1.1167282617169638 0.2641105301231081 1.0 0.5260849349621407 2 P11802 1 +Maternal placenta development 0.7058189730587243 1.11158111970582 0.2663182940106119 1.0 0.5292839690843568 3 P35613 1 +Positive regulation of insulin secretion involved in cellular response to glucose stimulus 0.7056426342177418 1.1108925650289987 0.2666145961638091 1.0 0.5293602285006684 3 P30626 1 +Response to light stimulus 0.4344649859065951 1.1102269164172125 0.2669012568115714 1.0 0.5297585551866039 40 P05067,P31751,P05556,Q9BRK5 4 +Regulation of potassium ion transport 0.5712335260043432 1.109934588141658 0.2670272145463022 1.0 0.529795143706216 10 P05026,P05556 2 +Extracellular exosome assembly 0.6283149734802147 1.1076283156787987 0.2680223694348029 1.0 0.5310929336605935 2 Q99816 1 +Regulated exocytosis 0.4719177929203509 1.1074692743351224 0.2680910894619335 1.0 0.5310929336605935 26 P11279,O95721,P51809,Q9BRK5,O43760,O15439 6 +Ubiquitin recycling 0.7028352750054805 1.1068160733152077 0.2683734574447156 1.0 0.5313104107675608 4 Q9Y263 1 +Secretory granule organization 0.7027358105349023 1.106433839810287 0.2685387853725152 1.0 0.5313419093333789 4 P22059,Q92692,Q9H267 3 +Regulation of cation transmembrane transport 0.4522953116829086 1.1054618520517507 0.2689595154775654 1.0 0.5313419093333789 35 P05067,P05026,Q06787,P05556,Q15334 5 +Histone h3 deacetylation 0.6949546917051374 1.1052957919601247 0.2690314407141057 1.0 0.5313419093333789 5 Q13547,Q9H4L7 2 +Dendritic spine maintenance 0.6274989800081637 1.1039900989943396 0.2695974326505799 1.0 0.5318524167989812 2 Q14247 1 +Retrograde vesicle mediated transport golgi to endoplasmic reticulum 0.5008292950702962 1.1018918150306207 0.2705087073967642 1.0 0.5332125025335934 19 O15258,P49755,P24390,P35606,Q6NUQ1,Q9Y282,Q12907 7 +Filopodium assembly 0.5691380021740685 1.1006225682400137 0.2710609590775523 1.0 0.533884301036625 10 P11233,P51114,Q06787 3 +Actin cytoskeleton reorganization 0.5004417945600403 1.0997404324649842 0.2714452327438548 1.0 0.5339579226849566 19 Q9Y624,Q9UQB8 2 +Positive regulation of cell substrate junction organization 0.6943238891867605 1.098602731233575 0.2719413858780255 1.0 0.5347630510542967 6 Q96AC1,Q15555 2 +Amyloid precursor protein catabolic process 0.5461233348159419 1.097545655660889 0.2724029341610601 1.0 0.5349871979679894 13 Q14254,P49755,Q96P70,Q15392,O75116,Q92542,P27695 7 +Cytokine mediated signaling pathway 0.450720069779842 1.0942228228826871 0.2738572641013785 1.0 0.5363038088651997 35 P67870,O94813,Q9ULM6,Q06481 4 +Positive regulation of t cell mediated immunity 0.6927875865493891 1.0928538791770113 0.2744579608947806 1.0 0.53679722529516 6 Q92692,Q9NUQ9,P01889 3 +Negative regulation of cellular response to growth factor stimulus 0.6127778151749973 1.0918411254519156 0.2749029391796731 1.0 0.5369852146349136 8 Q8N0X7,O94813,Q9Y2U8,Q9UPN9,P23634 5 +Humoral immune response 0.5667406560643966 1.0899708684255334 0.2757259767710311 1.0 0.5374939857205555 10 Q9UQ84 1 +Positive regulation of intracellular signal transduction 0.3803644940446543 1.0898607592749563 0.2757744844715339 1.0 0.5374939857205555 97 P05067,O75179,Q07021,Q9NUD5,P02786,Q9Y624,Q9UMX5,O43657,P05556,Q99873 10 +Cerebellar cortex development 0.5588340343765799 1.0886509572554837 0.2763078364087747 1.0 0.5381927708854244 11 P04062,P54802,P58546 3 +Receptor recycling 0.6911199298962836 1.0866152306519583 0.2772068911221588 1.0 0.5393637898981084 6 P42892,Q6IAA8 2 +Respiratory chain complex iii assembly 0.6991836734693851 1.0856947794619527 0.2776140511430685 1.0 0.5395422073509698 3 Q6DKK2,Q9BSK2 2 +Regulation of mast cell activation 0.6989098296470255 1.0846274811850252 0.2780866784181426 1.0 0.5402902111140752 3 Q92692 1 +Purine deoxyribonucleotide catabolic process 0.6226030191758494 1.0821832080440652 0.2791711283846161 1.0 0.5417134060712515 2 Q9Y3Z3 1 +Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.4634628442592554 1.0811948027541105 0.2796104694071499 1.0 0.5420534194394907 29 P09429,P36915,Q07021,Q92692,Q9UQ84,P02786,P01889,P42345,Q9NUQ9 9 +Bone morphogenesis 0.6880772249303932 1.0752375045991598 0.2822684081116942 1.0 0.5456598394799689 6 Q92896 1 +Positive regulation of dna binding transcription factor activity 0.4582033999922857 1.072537458665438 0.2834786984957671 1.0 0.5473120760476019 31 Q12899,P05067,P02786 3 +Inorganic ion import across plasma membrane 0.6862413909582121 1.0721257407457088 0.2836635586419405 1.0 0.5473257695263014 5 P55011,P05026 2 +Organonitrogen compound catabolic process 0.3660950730701401 1.0669880913427332 0.2859772135087672 1.0 0.5504100355028071 297 Q13126,Q9UIQ6,O75503,P06280,Q8IXB1,Q99538,P17900,P42892,P50897,P55786,Q9Y263,P16278,P15586,P06865,Q99519,Q8WTV0,P60900,P07686,P10619,O14773,P54802,Q16763,Q13510,Q13501,P30519,Q9NRN7,P49721,Q9UHG3,P04062,P08236,P28072,P49427,O43464 33 +Regulation of glucose import 0.6856500478537266 1.0661663317829029 0.2863484588061644 1.0 0.5509523315217357 6 Q06481 1 +Renal absorption 0.6185230518155884 1.064042296681352 0.2873095391221543 1.0 0.5521113709035905 2 Q9UNF1 1 +Extracellular transport 0.6185230518155884 1.064042296681352 0.2873095391221543 1.0 0.5521113709035905 2 Q99816 1 +Renal sodium ion transport 0.6185230518155884 1.064042296681352 0.2873095391221543 1.0 0.5521113709035905 2 Q9UNF1 1 +Multicellular organism aging 0.5681380261719573 1.0636704670584165 0.2874780076904333 1.0 0.5522627436349447 9 P04062 1 +Spermatid nucleus differentiation 0.6912095130296703 1.0622030783303784 0.2881435026688941 1.0 0.5531959918716498 4 Q92692,P26583 2 +Carboxylic acid transport 0.4656731235657921 1.0617450195058111 0.2883514556126099 1.0 0.5534226658998875 25 P55011,P08195,Q9H2J7,Q9H2D1,P05556 5 +Negative regulation of defense response to virus 0.6841318945964523 1.0604948277084707 0.2889195418115018 1.0 0.5536500525780942 6 O43657 1 +Regulation of autophagy of mitochondrion in response to mitochondrial depolarization 0.643907855267509 1.0597653612874238 0.2892513589661796 1.0 0.5538282263584111 7 P04062,O43464 2 +Negative regulation of cytokine production 0.4761357311592691 1.0568564950558297 0.2905770860791872 1.0 0.555443377519266 22 P04062,Q06481 2 +Tight junction organization 0.5371965719402931 1.0550106266787314 0.2914204646492777 1.0 0.5563645894094894 13 Q13177,Q16625,Q9Y624,O75116,P17612 5 +Cell killing 0.5057053572233154 1.0519451344926 0.2928247225899529 1.0 0.5586990446192563 17 Q92692,P11279,P51809 3 +Epithelial cell maturation 0.6156670746634055 1.051362141672487 0.2930922965013527 1.0 0.5587211664675338 2 P04818 1 +Mast cell activation 0.68831793253738 1.051129101774417 0.2931992997980512 1.0 0.5587211664675338 4 Q92692 1 +Cellular sodium ion homeostasis 0.6795746210132312 1.0467924094460288 0.2951953320055573 1.0 0.561754646681915 5 P55011,P05026 2 +Protein transmembrane transport 0.4786385557224458 1.044137818257791 0.2964216310018406 1.0 0.5632925870612138 21 Q99595,O14925,P31751,O96008,O60830,O95831 6 +Negative regulation of transmembrane transport 0.5186859476357062 1.0421978861910155 0.2973199428804196 1.0 0.5644058649340346 15 P31751,Q06481 2 +Localization within membrane 0.3663399400210668 1.0411580225143289 0.2978022143036682 1.0 0.564880790294593 131 Q9H4M9,P31751,Q5J8M3,Q15904,P05026,Q9UID3,O15118,P54709,Q9NS69,P05556,Q13501,Q9Y4C2,Q9HD20,Q9Y624,Q9HD45,Q15334,Q5W0Z9,O75436,P11233,P84095,Q8N4V1,P35613 22 +Positive regulation of adaptive immune response 0.5184364697140286 1.040946469715261 0.297900392913216 1.0 0.564880790294593 15 Q92692,P02786 2 +Peptidyl tyrosine modification 0.4602486242355367 1.0406900373802372 0.2980194284596287 1.0 0.564880790294593 27 P05067 1 +Organelle transport along microtubule 0.4620610798372415 1.0390774115044892 0.2987687353882304 1.0 0.5660058780877953 25 Q92572,P11279,Q9UH62,Q9Y678,O14617,Q66K74,Q5SNT2 7 +Sensory perception 0.4569908184091684 1.0386316785067322 0.2989760669746042 1.0 0.5662244369002271 29 Q14108,P50897 2 +Somatic diversification of immune receptors 0.4678284311243857 1.0371775249898392 0.2996531303685086 1.0 0.5669835045110349 23 P02786 1 +Regulation of ion transmembrane transport 0.4223920974519428 1.0355986039300562 0.3003894435629768 1.0 0.5678531790043747 45 Q9Y4C2,P05067,P05026,Q06787,O75844,P54709,O43865,P08183,Q15334,P05556 10 +Cellular response to dsrna 0.6374242332859283 1.0343512642173378 0.3009719792375462 1.0 0.5684308209096848 7 Q9NUD5,O75955 2 +Regulation of endodeoxyribonuclease activity 0.685756438784102 1.033474831803786 0.3013817427301952 1.0 0.5688620859623933 3 P09429 1 +Detection of stimulus 0.5538906392791761 1.032921429024045 0.3016406695700606 1.0 0.5691699670679937 10 Q8WTV0,Q9UNS1 2 +Regulation of cyclin dependent protein kinase activity 0.5322981129144193 1.0316834508695971 0.3022204325095865 1.0 0.5700892165936042 13 O95373,Q9P287,P54132 3 +Cerebellar purkinje cell layer development 0.6364530164331526 1.0305475661688073 0.3027530354281174 1.0 0.5707655822696571 7 P54802 1 +Positive regulation of anion transport 0.6364468324667532 1.0305233499963002 0.3027643968966542 1.0 0.5707655822696571 7 P55011,P08183,P05556 3 +Regulation of small gtpase mediated signal transduction 0.4554357957654691 1.028403823659935 0.3037599106477908 1.0 0.5719418256447854 29 Q13501,O75955,Q12802,O94813,Q9Y624,Q9NUQ9,Q15555,P05556 8 +Response to inorganic substance 0.3865749516833063 1.0259575510046206 0.3049115933356989 1.0 0.573721392175277 83 O60888,P05067,Q99538,P02786,O15118,Q92542,Q9UNS1,O95831,P35613 9 +Regulation of myotube differentiation 0.6837113756215957 1.0255435001406226 0.3051068110469144 1.0 0.5737760035479084 3 Q13547 1 +Cell junction assembly 0.4101217497912423 1.0238823797006995 0.3058908337406021 1.0 0.575074767432332 56 P05067,Q15375 2 +Stress fiber assembly 0.4791077715694363 1.0224830171571282 0.3065523465317117 1.0 0.5757909693702712 20 Q07157,Q13177,Q7Z460,P42345,Q9Y624,P60903,O75116,Q96AC1,P63167,P05556 10 +Regulation of proteolysis 0.3666364302825691 1.0209710126681666 0.307268172538867 1.0 0.5763195700762586 135 P05067,Q99538,Q15392,Q15375,P04062,O43464,Q92542,Q92896,Q92688,Q06481 10 +Ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway 0.6727478868916654 1.0209000520789844 0.3073017944713914 1.0 0.5763195700762586 5 Q9Y263 1 +Regulation of b cell mediated immunity 0.5367818500925519 1.0190376792892992 0.308185078716138 1.0 0.5772727501232923 12 P02786 1 +Demethylation 0.5294452685785348 1.0181043914729169 0.3086283486029275 1.0 0.5779272330742776 13 Q8NB78 1 +Regulation of innate immune response 0.4297691798400302 1.0148019184859196 0.3102002590613868 1.0 0.5796367208015049 38 P11279,Q92692,Q9NUD5,Q7Z739,Q06481 5 +Axoneme assembly 0.6804081632653033 1.0127465110881426 0.3111812555962698 1.0 0.5807647743880672 3 A0AVF1,Q15555 2 +Anterograde dendritic transport 0.6803035306780545 1.012341440812785 0.3113748270215715 1.0 0.5807739503095473 3 Q9NUL3 1 +Synaptic signaling 0.3903538937273921 1.011339316987618 0.3118540543259123 1.0 0.5811396526890563 67 Q13501,P05067,Q99538,P50897,P51790,Q92542 6 +Positive regulation of substrate adhesion dependent cell spreading 0.5413979693388443 1.00955185442322 0.3127100461635872 1.0 0.5823822608073825 11 Q96AC1,Q07021 2 +Protein o linked glycosylation 0.5339875323080752 1.006068045597 0.3143828386762259 1.0 0.5843173055136777 12 Q10472,O43505 2 +Positive regulation of supramolecular fiber organization 0.4436049052588754 1.0047318453954686 0.3150259895372436 1.0 0.5851025694059755 33 P05067 1 +Regulation of anatomical structure morphogenesis 0.3572274011585324 1.0043468536559854 0.3152114572614122 1.0 0.585147480154903 119 Q8N0X7,Q13177,O96013,P02786,Q9Y6C9,Q5VZL5,Q9Y263,O94813,P07686,Q96HC4,Q15375,P05556,P55011,O75844,Q9UQB8,Q9Y624,Q96HS1,Q15334,P38398,Q07021,P11233,P84095,Q7Z6Z7,Q9NUQ9 24 +Response to dexamethasone 0.5913479180176952 1.0035001772766514 0.315619591435365 1.0 0.585147480154903 8 P04062 1 +Late endosome to lysosome transport 0.6768450912024048 0.9989628958844082 0.3178126657914393 1.0 0.5883260923866181 3 Q9Y3E7 1 +Purine nucleoside triphosphate catabolic process 0.6034271725826226 0.997214024194584 0.318660635123523 1.0 0.5891872463830424 2 Q9Y3Z3 1 +Nitrogen compound transport 0.313277231302749 0.99632491758517 0.3190923006771615 1.0 0.589631241077216 438 P02786,P50897,O60830,Q14108,Q06481,Q15904,P10619,Q99523,Q9H2J7,A6NIH7,Q13501,O43772,Q99595,O00148,Q9UI26,Q8N4H5,Q9H2D1,Q5W0Z9,O75436,P08195,Q92688,O43464,O95831,O15127,Q8NC96,Q9Y282,P55786,O95373,Q658P3,Q8TEX9,Q16630,Q99747,O00170,P05556,P27348,P55011,Q96AX1,Q9HD20,Q86Y82,P51809,O14925,Q03519,Q96PU8,Q5SRE5,Q15334,Q12907,Q9BZH6,O95721,Q9Y3E7,P17858,P08183,O43808,Q7Z6Z7,P82979,Q9C0E2,Q9H4M9,Q9BSK2,P31751,O15439,Q9BVK6,Q8TB61,P05026,O14828,Q06787,Q9UID3,Q9NVZ3,Q9NPA8,Q969Q5,P24390,O96008,Q9NS69,Q9Y4C2,Q7Z3T8,Q6NUQ1,Q8NFH4,Q9BW83,Q9Y678,O00165,O43865,P35606,P50402,Q07955,Q96CS3,Q6ZWJ1,P61981,P55060,O00410,P40616,Q13546,O75955,P49755,Q9Y5K6,Q8NFH5,P48444,P49458,P61020,Q5VIR6,Q96KC8,Q96P70,Q4J6C6,O14617,O94979,P35579,P52294,P30626,Q92572 106 +Oxidative demethylation 0.6030191758465964 0.9954150852144652 0.3195344247240415 1.0 0.5897402437128068 2 Q6P6C2 1 +Oxidative rna demethylation 0.6030191758465964 0.9954150852144652 0.3195344247240415 1.0 0.5897402437128068 2 Q6P6C2 1 +Negative regulation of canonical wnt signaling pathway 0.5376152217264811 0.9924192232933629 0.3209930654098269 1.0 0.5913687324142144 11 Q13547,Q99471,P48729 3 +Golgi localization 0.6651258998573633 0.9920589604808911 0.3211687645742158 1.0 0.5915154302971724 5 Q9Y678 1 +Cellular response to nutrient 0.6722404311875407 0.9897551104957336 0.3222938307951388 1.0 0.5928918781043104 4 Q96C86,Q13573 2 +Protein insertion into er membrane 0.5234404243102471 0.9895428871549988 0.3223975975139241 1.0 0.5928918781043104 13 Q5J8M3 1 +S adenosylmethionine metabolic process 0.6719257901648442 0.9885577791118256 0.3228795520033896 1.0 0.5934237019954834 4 Q9BV20 1 +Cellular response to epinephrine stimulus 0.6739507064706023 0.9877822710477848 0.3232592920871546 1.0 0.5935900570774266 3 P23634 1 +Response to epinephrine 0.6739507064706023 0.9877822710477848 0.3232592920871546 1.0 0.5935900570774266 3 P23634 1 +Amyloid precursor protein metabolic process 0.5151546572708726 0.9852928557473668 0.3244802409614347 1.0 0.5949448611076693 14 Q14254,P49755,Q96P70,Q15392,O75116,Q92542,P27695 7 +Regulation of protein autophosphorylation 0.6635560528817339 0.9838450167291368 0.3251917214833626 1.0 0.5955399848819344 6 Q15375,Q9C0C2 2 +Defense response to other organism 0.3587703262080656 0.983060661358362 0.3255775839878057 1.0 0.596069338273244 125 O75179,P11279,O00584,Q9P032,Q07021,Q8IWZ3,P10321,Q92692,Q9NUD5,O95373,Q7Z739,P51809,P01889,Q12899,O43657,Q06481 16 +Mature ribosome assembly 0.6626509555191097 0.9827109847907908 0.3257497028007332 1.0 0.596207170078512 5 Q7Z2Z2,Q07021 2 +Response to steroid hormone 0.4025967196676602 0.9822796591443892 0.3259620926469355 1.0 0.5964186045846009 58 O94813,O15118,Q9H7B4,P04062,O95831,P16278 6 +Adaptive immune response 0.4243186444112064 0.9740150651850686 0.3300490590969955 1.0 0.6007688082471542 38 P09429,P36915,Q07021,P10321,Q92692,Q9UQ84,P02786,P01889,Q6P179,P42345,Q03519,Q9NUQ9 12 +Establishment of protein localization to membrane 0.3840649660972096 0.9706074497875264 0.331743794763965 1.0 0.6025644406833259 68 Q9Y4C2,Q5W0Z9,Q9HD20,Q15904,P05026,O15118,P31751,Q8N4V1,Q9NS69,Q5J8M3 10 +Positive regulation of sodium ion transmembrane transport 0.6594022615694453 0.9684303500387492 0.3328294880838645 1.0 0.6039584904604638 6 Q9UHD1,P54709,O43707,P05026 4 +Centrosome separation 0.6661817816442906 0.9667284425804412 0.3336798045819844 1.0 0.6044326439574221 4 P43487,Q9UNZ2 2 +Hypothalamus development 0.6680650408715862 0.9650945457309164 0.3344974585936247 1.0 0.6053794393183266 3 O14949 1 +Protein localization to plasma membrane 0.4017635094067331 0.9629536355353798 0.3355707912861119 1.0 0.6061742802635703 57 Q9H4M9,P31751,Q14651,O15258,O75955,P05026,Q15904,P54709,O00264,P05556,Q13501,Q14254,Q4J6C6,Q9Y624,P84095,P60903,Q96CW1,P35613,Q9H8Y8 19 +Positive regulation of sodium ion transmembrane transporter activity 0.6572230023604604 0.9622414772136636 0.3359283186375366 1.0 0.6063648952950198 5 Q9UHD1,O43707,P05026 3 +Biological process involved in interaction with symbiont 0.4551158833575088 0.9600348415231904 0.3370376798826435 1.0 0.6081890372325429 23 Q13547,P11717,Q13573,Q06787 4 +Response to testosterone 0.5804094819067307 0.9585857090761226 0.3377674947402214 1.0 0.6091489353003934 8 P04062 1 +Monosaccharide catabolic process 0.5166913488701227 0.9574838099163804 0.3383231143038288 1.0 0.6099723030069323 13 P16278 1 +Immune response to tumor cell 0.6632223038816776 0.9555037630228208 0.3393230032897061 1.0 0.6112380723390054 4 P09429,Q92692 2 +Amyloid beta metabolic process 0.5360646587895895 0.954001878926648 0.3400826912933556 1.0 0.6121289318638136 10 Q92542,P49755,O75116,P27695 4 +Protein demethylation 0.6550171919580784 0.9539364422019012 0.3401158154793091 1.0 0.6121289318638136 5 Q8NB78 1 +Neurotransmitter secretion 0.5008842987294697 0.9530157242843968 0.3405821037429275 1.0 0.6125364314216011 15 O95721,P50897 2 +Immune response regulating cell surface receptor signaling pathway 0.4805319332818356 0.9522045696478372 0.3409932439565319 1.0 0.6125364314216011 18 Q92692,Q13177,Q06481,Q9NR50 4 +Cellular modified amino acid catabolic process 0.6536344563839194 0.9487344818724914 0.3427556718234799 1.0 0.6147237609720844 5 Q9NRN7 1 +Regulation of vascular permeability 0.6152726655873628 0.9478617520782924 0.3431998385395809 1.0 0.6153411199441468 7 O94813,Q96AC1,Q9UDY2 3 +Immune response regulating signaling pathway 0.4131553050424087 0.9475861358440572 0.3433401869185075 1.0 0.615413546101092 41 O75179,Q07021,Q92692,O43657,Q06481 5 +Positive regulation of neuron apoptotic process 0.5268990868768957 0.9439678722470513 0.3451860662391968 1.0 0.6177964946935034 11 Q15375,P49427 2 +Regulation of transmembrane receptor protein serine threonine kinase signaling pathway 0.4610622077094903 0.9419626180008313 0.346211779013873 1.0 0.6187593391548377 21 Q9Y2U8,P67870,Q13573,Q92896 4 +Response to cold 0.5263464113022898 0.9414729939947594 0.346462522436366 1.0 0.6188581842484067 11 Q13217,Q06481 2 +Steroid biosynthetic process 0.4344188824672257 0.9410415863634676 0.3466835482341386 1.0 0.6188581842484067 33 Q15392,Q9UBM7,Q14849,Q13510 4 +Positive regulation of mapk cascade 0.4403320519710842 0.9396633900382768 0.347390249578285 1.0 0.619003274584735 30 P05067,Q12802,Q9UMX5,Q6IAA8,Q96AC1,Q99873,Q13546 7 +Nucleobase containing small molecule interconversion 0.6590055883265984 0.939538824032454 0.3474541687453052 1.0 0.619003274584735 4 Q9Y3D8,P00568 2 +Mrna alternative polyadenylation 0.651009161095923 0.9388669918989484 0.3477990382512907 1.0 0.6190802771070244 5 Q16630 1 +Cellular amide metabolic process 0.307381817408746 0.9360134198736544 0.3492662782559492 1.0 0.6207945944635911 402 P05067,Q9UIQ6,O75503,P06280,Q9ULC4,P17900,P42892,P50897,O75976,P55786,P06865,Q99519,P07686,Q96G23,O14773,Q567V2,Q9Y2L1,Q92542,Q13510,Q9NRN7,Q9ULM6,Q9H0R6,Q7Z739,P04062,Q7Z2Z2,Q9H2D1,O15269,Q07021,Q15056,O43464,Q96C86 31 +Regulation of cellular response to heat 0.6502207248306234 0.9344449356591424 0.3500744275332144 1.0 0.6218719706641666 6 P25685,Q99543,P42345,Q99615 4 +Endothelin receptor signaling pathway 0.5883312933496572 0.9309546352532994 0.3518770309184638 1.0 0.6241736903961341 2 P60953 1 +Reelin mediated signaling pathway 0.5883312933496572 0.9309546352532994 0.3518770309184638 1.0 0.6241736903961341 2 P43034 1 +Endosome to lysosome transport 0.5110028789405544 0.9305068187257628 0.3521087353169827 1.0 0.6242599921337808 13 Q96AX1,Q99523,P51809 3 +Establishment of protein localization to organelle 0.3642635990367122 0.9298426117464114 0.3524525799686004 1.0 0.6243758209041343 146 Q13501,Q8TEX9,P11279,Q99595,P11233,O95373,O95831,Q99523,O00170,Q9UI26,O14925,O43464,O60830,P55786,Q8N4H5,Q14108,Q06481 17 +Negative regulation of proteolysis 0.4003451286087328 0.9289564182218067 0.3529116727214114 1.0 0.6244622212573038 55 P05067,Q06481,Q92896 3 +Cellular response to exogenous dsrna 0.6480466335978443 0.9277467972802024 0.3535389273743619 1.0 0.6251404870315755 5 Q9NUD5,O75955 2 +Regulation of synaptic plasticity 0.4442679926360066 0.9243164040886784 0.3553216044373972 1.0 0.6272119032457153 24 Q13501,P05067,Q99538,Q92542 4 +Small gtpase mediated signal transduction 0.3791179466890061 0.9231485293192334 0.355929807459217 1.0 0.6278865785586158 68 Q13501,Q02818,Q12802,P11233,O94813,P80303,Q9Y624,Q15392,P05556,P27348 10 +Organic cation transport 0.6546261871522044 0.922995112158314 0.3560097524359473 1.0 0.6278865785586158 4 O43772 1 +Endomembrane system organization 0.3521524789472117 0.9192729934725256 0.357952799968565 1.0 0.6305909554811029 122 Q5JTV8,Q92692,O43760,P40616,P31751,Q9BVK6,Q5J8M3,Q14108,O75955,Q7Z392,Q9UID3,P49755,P51790,Q6IAA8,Q13501,P61020,O75844,P49069,Q9UQB8,Q14203,Q9Y2U8,Q9UNF0,O14617,O94979,Q12907,O95721,Q9Y3E7,P48729,Q8N4V1,P50402,Q7Z6Z7,Q9H8Y8 32 +Import into cell 0.4678107490701191 0.9187336454851942 0.3582349068676913 1.0 0.6307246821748226 19 P55011,P05026,P08195,P54709,P31751,P05556 6 +Odontogenesis of dentin containing tooth 0.6074207359302645 0.9173688814935984 0.3589493735508544 1.0 0.6316236904694514 7 Q13547,Q6P4Q7,P35613 3 +Positive regulation of glial cell differentiation 0.6448252163339445 0.9156735068181148 0.3598381645589732 1.0 0.6324438576682707 5 Q13547,P42345 2 +Mapk cascade 0.3801965067752305 0.9148253359412308 0.360283331790197 1.0 0.6325248000662227 67 P05067,P04062,Q15375,Q9UMX5,Q99873 5 +Regulation of postsynapse organization 0.4930884556254326 0.9140718401032 0.3606790981465608 1.0 0.6327199819384988 15 Q15375 1 +Maternal process involved in female pregnancy 0.6443854041686496 0.9140267317645848 0.3607027995134206 1.0 0.6327199819384988 5 P35613,Q9BQE5 2 +Ribosome disassembly 0.6515343308985586 0.9113394114417168 0.3621165667452568 1.0 0.6346574726588519 4 Q9ULC4 1 +Positive regulation of non motile cilium assembly 0.6512862392813327 0.910405053056504 0.3626089338588691 1.0 0.6351588067621786 4 P27695,Q16181,Q15555 3 +Positive regulation of focal adhesion assembly 0.6510857040413089 0.9096498999432896 0.3630071735913747 1.0 0.6356755312292645 4 Q96AC1 1 +Skeletal system development 0.4214306273158263 0.905344951655192 0.3652826691301787 1.0 0.63875188691693 36 P07686,Q15904 2 +Regulation of actin filament organization 0.4002441612405107 0.9007971629916328 0.3676961762543562 1.0 0.6420605096988291 52 Q9NYL9,Q13177,Q13045,O94813,Q9UQB8,Q9UHB6,Q14247,Q14019,P58546,O15143,Q9Y624,P42345,O00165,P60903,Q9NUQ9,Q96AC1,P62993 17 +Positive regulation of megakaryocyte differentiation 0.6506122448979557 0.8982491503535541 0.3690527352438693 1.0 0.6432480728941508 3 Q9GZP4,P26583 2 +Protein refolding 0.5298714203853281 0.8981377361951252 0.3691121229555743 1.0 0.6432480728941508 9 P48723 1 +Viral protein processing 0.5655092039700402 0.8976896766702555 0.3693510146350482 1.0 0.6433081179937744 8 Q10472,Q99873 2 +Dicarboxylic acid transport 0.503884509316652 0.8968190061636931 0.3698155044246889 1.0 0.6433558980856113 13 Q9H2D1,P05556 2 +Cardiac muscle cell differentiation 0.4896184561543871 0.8967689060723768 0.3698422431199843 1.0 0.6433558980856113 15 Q12802,P05556,Q96HC4,O75844 4 +Regulation of ion transport 0.3914718160154097 0.8966589974644193 0.3699009061593412 1.0 0.6433558980856113 59 Q9Y4C2,P05067,P55011,P05026,Q06787,O75844,P51809,P54709,P08183,Q15334,P20020,P05556 12 +Cytoskeleton dependent intracellular transport 0.4030323717419727 0.8959982659116786 0.3702536893827179 1.0 0.6435902315960776 48 P05067,Q00577,P11279,Q14254,Q9BW83,Q9UH62,Q9Y678,Q14203,Q9NUL3,O14617,Q66K74,Q5SNT2 12 +Regulation of histone h4 acetylation 0.647408676205947 0.8958193997940997 0.370349226984717 1.0 0.6435902315960776 4 P38398 1 +Histone exchange 0.6392507592993976 0.8948302473260099 0.3708778385352231 1.0 0.6441782658994222 5 Q9GZN1,Q6ZRS2 2 +Regulation of protein phosphorylation 0.3527967029541183 0.8939817358018379 0.3713316633571897 1.0 0.644563237752766 127 P05067,Q13177,P61981,Q8IXB1,P02786,O00410,P31751,P54132,Q13610,Q96AC1,O95373,Q13546,Q06787,O94813,Q13217,Q15375,Q13501,Q96A49,Q12802,P04062,P51114,Q15334,Q9C0C2,P67870,Q8WUA2,P42345,O00165,Q9H7B4,Q9P287 29 +Regulation of response to cytokine stimulus 0.4692529785415961 0.8913942916742592 0.372717679033141 1.0 0.6464289436076195 18 O94813 1 +Regulation of rho protein signal transduction 0.515109833682732 0.890853833294201 0.3730075903954142 1.0 0.6467495730961884 11 Q9Y624,P05556 2 +Apical protein localization 0.6485714285714252 0.8904800809983964 0.3732081593496821 1.0 0.6467849072747188 3 P18085,P54920 2 +Gtp metabolic process 0.5280647275616668 0.8903766238264386 0.3732636899958428 1.0 0.6467849072747188 9 P15531,Q8IWA4,Q7Z2Z2 3 +Interferon gamma production 0.6381619048359197 0.8900199409521266 0.3734551787793272 1.0 0.6467849072747188 6 P09429,Q9NUQ9,Q07021 3 +Pyrimidine deoxyribonucleotide biosynthetic process 0.645829572391237 0.8898894516272268 0.3735252484742419 1.0 0.6467849072747188 4 P23919,P33316 2 +Regulation of actin filament based process 0.375774759965513 0.8896417861956277 0.3736582613571828 1.0 0.6467849072747188 69 Q13177,Q13045,Q9UHB6,P58546,Q96AC1,Q9NYL9,O94813,Q9Y5K6,Q9NUL3,Q12802,Q14126,Q9UQB8,O15143,Q9Y624,P35579,P30626,Q14019,P42345,O00165,P84095,Q9NUQ9 21 +Membrane fusion 0.4340064838522345 0.8875914601357059 0.37476054899734 1.0 0.6478188616230924 29 Q86Y82,O95721,Q92692,Q9Y3E7,P51809,Q8IWA4,Q7Z6Z7,Q99747 8 +Protein localization to cell periphery 0.3826701461927014 0.8871915741104612 0.374975768050902 1.0 0.6479724400475453 64 Q9H4M9,P31751,Q14651,O15258,O75955,Q9UPT5,P05026,Q15904,P54709,O00264,P05556,Q13501,Q14254,Q4J6C6,Q9Y624,Q15334,P84095,P60903,Q96CW1,P35613,Q9H8Y8 21 +Regulation of actin filament bundle assembly 0.4683119943962971 0.886330664414958 0.3754393696751874 1.0 0.64822776194339 18 Q07157,Q13177,Q7Z460,P42345,Q9Y624,P60903,O75116,Q96AC1,P63167 9 +Carbohydrate biosynthetic process 0.4213277364354949 0.8844759469944887 0.3764393411355815 1.0 0.648680946927449 35 Q8NCH0,O43505 2 +Chromatin remodeling at centromere 0.5769073847409264 0.8812856890946309 0.3781632098959746 1.0 0.650922807752171 2 P49321 1 +Collagen metabolic process 0.5251804358868506 0.878000372264801 0.3799435166970859 1.0 0.6534391710346251 9 Q32P28,Q92769,Q92791,O60568,P05556 5 +Positive regulation of cell projection organization 0.39578608895581 0.871640295628511 0.3834046406232247 1.0 0.6569470582011792 53 Q32P28,Q9H4M9,Q06787,P11233,O94813,Q9UQB8,Q9NQW6,Q16625,P42345,Q9NUL3,Q14444,Q15555,Q15428,Q14108,Q15334 15 +T cell proliferation 0.4520967340910409 0.8688644863091531 0.3849212562768391 1.0 0.6590545536419629 20 P02786 1 +Chaperone mediated protein complex assembly 0.4977354006524734 0.867793740302759 0.3855072574536924 1.0 0.659469945727818 13 O95456 1 +Protein maturation by protein folding 0.631934950235017 0.8675775257660445 0.3856256541250213 1.0 0.659469945727818 5 O00170 1 +Regulation of ras protein signal transduction 0.4397575467643621 0.8670517986165079 0.3859136291143947 1.0 0.659469945727818 23 Q13501,Q9Y624,P05556 3 +Protein autophosphorylation 0.4342632512697975 0.8648713140756552 0.3871094238413559 1.0 0.6611463862943768 25 Q9C0C2,Q13177,P42345,Q15375,Q9BVS4,Q9H2G2,Q13546 7 +Negative regulation of defense response 0.439270573846257 0.8641102311731429 0.3875273391429057 1.0 0.6612640820582019 23 Q7Z739,O43657,P04062,Q07021 4 +Regulation of actin filament length 0.4094828069224975 0.8631310774439228 0.3880654028548904 1.0 0.6612640820582019 38 Q9NYL9,O94813,Q9UQB8,Q9UHB6,P42345,P58546,O15143,O00165,Q9NUQ9 9 +Organic anion transport 0.4207502815500276 0.8624128071310128 0.3884603954065773 1.0 0.6616184383176477 34 P55011,P08195,O15439,O43808,Q9H2J7,Q9H2D1,P05556 7 +Cellular hormone metabolic process 0.4891573506623666 0.8589839333901375 0.390349380183947 1.0 0.6634322580440888 14 Q9HB40,P42892 2 +Cellular response to ionizing radiation 0.463146768218711 0.8585680807554076 0.3905788545857664 1.0 0.6634322580440888 18 O75844,Q9NXR7,P54132,Q9H1E3,P38398 5 +Response to insulin 0.3990616092888141 0.8584008579377299 0.3906711540203558 1.0 0.6634322580440888 47 Q6ZWJ1,Q96A49,Q9BSK2,Q9UQB8,Q99523,P20020,P42345,P31751,Q13243,Q9H1E3,Q06481 11 +Stem cell proliferation 0.5142375964281046 0.8579967282426548 0.3908942700425786 1.0 0.6634322580440888 10 P04062,P08183,Q15020,P26583 4 +Metal ion transport 0.3724544044500694 0.8558108928795186 0.3921023890332678 1.0 0.6645126367403881 74 P55011,Q9HD20,P05026,Q06787,O75844,P08195,P02786,Q93034,Q9UM00,P54709,O43865,Q8N4V1,Q9H2J7,P20020,P13693,P05556,Q658P3 17 +Regulation of response to biotic stimulus 0.3923658298965757 0.8513989979162827 0.3945477482227839 1.0 0.6677379015414187 54 O75179,P11279,Q07021,Q92692,Q9NUD5,Q7Z739,O43657,Q06481 8 +Regulation of tau protein kinase activity 0.5695634434924568 0.8496097231854876 0.3955421043458509 1.0 0.6682461216000487 2 P07900 1 +Positive regulation of tau protein kinase activity 0.5695634434924568 0.8496097231854876 0.3955421043458509 1.0 0.6682461216000487 2 P07900 1 +Response to leucine 0.6376173339937597 0.8489735301307693 0.3958960213986437 1.0 0.6683662746782149 3 P42345 1 +Vesicle organization 0.3763024392330683 0.8440176734580744 0.3986595297070145 1.0 0.6710078524893627 65 Q13501,Q86Y82,O95721,Q92692,Q9Y3E7,Q99523,P51809,P31751,P51790,Q6IAA8,Q9BVK6,Q14108,Q15334 13 +Cell cell adhesion 0.3711282478790917 0.8428234312559462 0.3993272014425395 1.0 0.6715808738819219 71 O96013,Q92692,P02786,Q9NYL9,P09429,O75955,P04439,Q96HC4,Q9Y5K6,Q15375,P05556,Q14254,Q14126,Q9UQB8,Q9Y624,O14617,Q15334,P35579,Q9UDY2,P35613,Q9NUQ9 21 +Negative regulation of camp dependent protein kinase activity 0.5675234598123262 0.8408496680166104 0.4004321582060826 1.0 0.6731058215926454 2 P10644 1 +Cytoplasmic pattern recognition receptor signaling pathway in response to virus 0.5033360189774504 0.8380767031286953 0.4019876261628738 1.0 0.6745810341468559 11 O75179,O43657,Q07021 3 +Cation transmembrane transport 0.3608761305252704 0.8369015533608893 0.402647907155373 1.0 0.6749532165411467 94 P55011,P05067,P61421,O43772,Q9HD20,P05026,Q06787,P08195,Q93034,Q13423,P54709,Q9UM00,Q8N4V1,P51790,Q9H2J7,Q15334,P05556 17 +Positive regulation of protein kinase b signaling 0.5027832953045769 0.8356069407151954 0.403376062825266 1.0 0.6758675229683703 11 O00165,P05556,Q07021 3 +Regulation of neurotransmitter levels 0.4384748163285809 0.8336625942480385 0.4044711422734175 1.0 0.6774412442693518 22 O95721,P50897,P05556 3 +Regulation of neuron projection development 0.3891907720672056 0.8334832011328804 0.4045722681790493 1.0 0.6774412442693518 55 O94813,Q14108,Q15375 3 +Pyrimidine containing compound biosynthetic process 0.4952055421771588 0.8271580243273361 0.4081474997793426 1.0 0.681462547170687 12 P15531,P42345,P23919,Q9NRF8,P33316 5 +Activation of phospholipase d activity 0.6307697698788137 0.8232077809718045 0.4103898448269283 1.0 0.6833236499470261 3 P40616 1 +Response to ether 0.6306122448979554 0.8226168096071342 0.4107259364745959 1.0 0.683350512078926 3 P11802,Q14103 2 +Macromolecule catabolic process 0.3290914223681773 0.8209308159149339 0.4116856769468422 1.0 0.6846971131717201 336 O00584,Q9UIQ6,O75503,Q8IXB1,Q99538,P10253,P50897,Q9Y263,P16278,P15586,P60900,P10619,O14773,P54802,Q9Y2L1,Q16763,Q13501,Q9ULM6,P49721,Q9UHG3,Q7Z739,O43847,P04062,P08236,P28072,Q9UG56,Q9Y3E7,P49427,Q92804,Q93034,O43464,Q96C86,O95831 33 +Positive regulation of lipid storage 0.6189032018910464 0.8193542027735892 0.4125843560206792 1.0 0.6856361349579817 5 Q8WTV0,Q9H4M9 2 +Regulation of response to tumor cell 0.6293276761451778 0.8178006646928943 0.4134710184623289 1.0 0.68669630232524 3 Q92692 1 +Cytoplasmic pattern recognition receptor signaling pathway 0.4870692055420969 0.817650279030271 0.4135569090501851 1.0 0.68669630232524 13 O75179,O43657,Q07021 3 +Response to radiation 0.3716646106613963 0.8169117685403058 0.4139788518714327 1.0 0.6870263587526715 66 P05067,Q9ULM6,Q06787,O75844,Q9NXR7,Q9BRK5,Q70UQ0,P31751,P54132,Q9H1E3,P05556,P38398 12 +I kappab kinase nf kappab signaling 0.4114939050391953 0.8145442600446963 0.4153332275672521 1.0 0.6883293168520986 35 Q13501,O43657,P02786 3 +Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway 0.5806108386836848 0.8141717898557782 0.4155465438913839 1.0 0.6883293168520986 7 O75179,O43657,Q07021 3 +Positive regulation of protein dephosphorylation 0.5038688223474339 0.8127508598534983 0.4163609147176454 1.0 0.6885307786285424 10 Q14738,P04062 2 +Positive regulation of dephosphorylation 0.5038688223474339 0.8127508598534983 0.4163609147176454 1.0 0.6885307786285424 10 Q14738,P04062 2 +Sensory perception of light stimulus 0.4859769756373943 0.8125322473820167 0.4164862905800763 1.0 0.6885307786285424 13 Q6P4Q7,P50897,Q92696 3 +Protein insertion into membrane 0.4348139712508815 0.8120988600933102 0.4167349072233157 1.0 0.6885307786285424 22 Q9NS69,Q5J8M3,Q8N4V1 3 +Plasma membrane repair 0.6249281021859513 0.8120090189481011 0.4167864563827477 1.0 0.6885307786285424 4 Q9Y3E7,P35579 2 +Positive regulation of protein localization to cell periphery 0.472263773906074 0.8106184517410024 0.4175848171916851 1.0 0.6893654708789166 15 Q13501,Q14651,O15258,O00264,P84095,P05556 6 +Response to acid chemical 0.4481854578264767 0.8105439571578544 0.4176276118853921 1.0 0.6893654708789166 19 Q9UQB8,P42345,O00410,Q99729,P17655,Q6IAA8,P26358,P23634,O95831 9 +Response to hormone 0.3524227877727782 0.8097801444245606 0.4180665463025004 1.0 0.689423830259389 140 Q6ZWJ1,Q9BSK2,P61981,P31751,Q96T76,Q06481,P16278,Q13547,Q15185,O94813,Q99523,O15118,Q9H1E3,Q96A49,Q9UQB8,O15143,Q15392,P04062,P20020,Q9NR50,P38398,P67870,P42345,P42785,Q9H7B4,O43865,Q13243,O95831,P35613 29 +Regulation of fat cell differentiation 0.5091597249032837 0.8096164764369261 0.4181606354659664 1.0 0.689423830259389 9 Q96A49,Q99523 2 +Actin filament polymerization 0.4053374148325288 0.8095571791590218 0.4181947272573212 1.0 0.689423830259389 37 Q9NYL9,O94813,Q9UQB8,P42345,P58546,O15143,O00165,Q9NUQ9 8 +Positive regulation of proteolysis 0.3674857671418902 0.8085917388512998 0.4187500181839569 1.0 0.6895543893978666 76 P05067,Q99538,P04062,Q92542,O43464,Q92688 6 +Regulation of lipid storage 0.6157428101266159 0.8082237224749865 0.4189618038076228 1.0 0.689718670065116 6 Q8WTV0,Q9H4M9 2 +Response to estrogen 0.5026711301009095 0.8075431765889053 0.4193536095087058 1.0 0.6899118598054349 10 O15143,P04062 2 +Leukocyte proliferation 0.4226438287463672 0.8057995187465347 0.4203584555996773 1.0 0.6905408247404518 28 Q92542,P02786 2 +Dephosphorylation of rna polymerase ii c terminal domain 0.5589555283557763 0.8042570456586591 0.4212485394333598 1.0 0.691493528427991 2 Q9NP77 1 +Response to redox state 0.5585475316197523 0.8025229728779736 0.4222505050623069 1.0 0.6928947472181448 2 P11766 1 +Positive regulation of extrinsic apoptotic signaling pathway 0.541602285176213 0.8009498416346001 0.4231606840881103 1.0 0.6934789278494797 8 Q13177,O43464 2 +Positive regulation of neuron death 0.4577605612962734 0.8000501869982606 0.4236817202516136 1.0 0.6939633816411773 17 Q15375,P49427 2 +Positive regulation of potassium ion transport 0.613173384577828 0.7989275692762867 0.4243324119081977 1.0 0.6946595746128087 6 P05026 1 +Rna phosphodiester bond hydrolysis exonucleolytic 0.4574267767837995 0.798313204375255 0.4246887572897744 1.0 0.694873419780266 17 Q9ULM6,Q9NVH0,Q9NQT5,Q9Y3B8,Q9Y2L1,Q15024,Q96C86 7 +Determination of adult lifespan 0.6125570762419089 0.7967004467566341 0.4256250244271076 1.0 0.6960353985120057 6 P04062 1 +Actin polymerization or depolymerization 0.3931441724217364 0.7962816139801642 0.4258683697223291 1.0 0.6962484207064208 43 Q9NYL9,O94813,Q9UQB8,Q9UHB6,P42345,P58546,O15143,O00165,Q9NUQ9 9 +Regulation of gliogenesis 0.5052125650132 0.7928759891591436 0.427850077837133 1.0 0.6989315280560435 9 Q13547,Q96G23,P42345 3 +Mrna methylation 0.6114540317708744 0.791998362627441 0.4283616309600728 1.0 0.6995815813849253 5 Q8N1G2,Q69YN4,Q9UJA5 3 +Negative regulation of signaling receptor activity 0.6223573243249128 0.791765060169743 0.428497678725106 1.0 0.6996181935588645 3 P30533 1 +Establishment of golgi localization 0.6190281747652011 0.7902569296529734 0.4293777346964524 1.0 0.7003446803880637 4 P60953,Q9Y678,P63104 3 +Regulation of cell projection organization 0.3535709986577378 0.7873636018505923 0.4310690474866039 1.0 0.7012872244213002 97 Q8N0X7,Q13177,Q4KMP7,Q9H4M9,Q14444,Q15555,P27695,Q14108,Q14651,Q06787,O94813,Q96G23,Q9NQW6,Q96HC4,Q9NUL3,Q15375,Q9UQB8,P51114,O60828,Q15334,Q32P28,P11233,P42345,Q16625,P84095,Q15428 26 +Cellular response to ketone 0.4739095211392755 0.7855678342824629 0.4321207149641295 1.0 0.7023434429288805 14 Q9H7B4,Q96C86 2 +Regulation of cell morphogenesis 0.3795846408086302 0.7806102491207689 0.4350317618971444 1.0 0.7050514761781306 58 Q07021,P07686,Q9UQB8,Q9Y624,P84095,Q9Y263,Q15334,Q5VZL5 8 +Export from cell 0.3508290729758205 0.7799422714824434 0.4354248555226376 1.0 0.7053172416345383 99 Q6ZWJ1,O43760,P50897,O15439,Q658P3,P11279,P05026,Q06787,Q7Z392,P49755,Q9Y5K6,P54709,P55011,Q96KC8,P51809,Q4J6C6,Q9BRK5,P20020,Q15334,P35579,P30626,P11233,O95721,Q9Y678,Q9Y3E7,P17858,P08183 27 +Regulation of sodium proton antiporter activity 0.618775510204078 0.7784535526548595 0.4363016784807163 1.0 0.7063568337731906 3 Q9UHD1,O43707 2 +Mitochondrial transmembrane transport 0.391343851241325 0.7782683732145276 0.4364108162535678 1.0 0.7063568337731906 41 O60830,Q9H2D1,O43772,Q99595 4 +Nucleic acid phosphodiester bond hydrolysis 0.3640468470481536 0.7730882053703313 0.4394701808796077 1.0 0.7080639648602596 74 O00584,Q16630,Q9UQ84,Q8IV08,Q9Y2L1,Q96C86,O95831 7 +Endoplasmic reticulum membrane organization 0.6055405995199934 0.7714214703751608 0.4404571529408989 1.0 0.7080639648602596 6 Q8NHH9,Q9NQC3 2 +Regulation of adaptive immune response 0.4409730805406083 0.7710440911958724 0.4406807977470433 1.0 0.7080639648602596 19 P09429,Q92692,P01889,P02786,Q9NUQ9 5 +Response to epidermal growth factor 0.4998937223075766 0.7703958960036901 0.441065087125871 1.0 0.7080639648602596 9 Q9UQB8 1 +Membrane organization 0.3604022093004427 0.7703347674039072 0.4411013377686639 1.0 0.7080639648602596 171 Q92692,P61916,O43760,P50897,P31751,Q5J8M3,Q9BVK6,Q06481,P05026,O15118,Q8IWA4,P51790,Q9NS69,Q99747,Q86Y82,O75844,P49069,Q9UQB8,Q14203,P51809,Q14849,Q15392,Q15334,O95721,Q9Y3E7,P84095,Q8N4V1,P08183,Q7Z6Z7 29 +Negative regulation of epidermal growth factor activated receptor activity 0.5503875968992303 0.7680144871159041 0.4424785781099658 1.0 0.7083104905529087 2 Q99816 1 +Renal water homeostasis 0.615918367346935 0.7678696417930003 0.4425646349126262 1.0 0.7083104905529087 3 P17612,O76024 2 +G protein coupled receptor signaling pathway 0.4092900741724904 0.7675309438731224 0.4427659025182637 1.0 0.7084484568100182 33 P11717,P42892,Q06481 3 +Regulation of translational elongation 0.6045068227128629 0.7666396233509223 0.4432958102039661 1.0 0.7087437817257386 5 Q9BQC3,P49458 2 +Response to dsrna 0.4813389689480159 0.7640035915238832 0.4448651023206058 1.0 0.7099622693074055 12 P08195,Q9NUD5,O75955 3 +Regulation of binding 0.362570046131298 0.7627156939321782 0.4456329689361604 1.0 0.7110034179165431 69 Q04637,P05067,P09429,P30626,O75955,O75503,Q06787,P15531,O75844,P67870,P48729,Q15691,P26583,P30533,Q9H1E3 15 +Sensory perception of mechanical stimulus 0.4624050796810679 0.7620527095234206 0.4460285458646982 1.0 0.7112427763168925 15 Q14108 1 +Negative regulation of bmp signaling pathway 0.6109604759983676 0.7607018883096935 0.4468351466957072 1.0 0.7118147472717903 4 Q9Y2U8,Q8N0X7 2 +Negative regulation of neuroblast proliferation 0.5479396164830738 0.7577291418021154 0.4486131494172261 1.0 0.7139598222807859 2 P04637 1 +Copi coated vesicle budding 0.6130532183988269 0.7572878106313442 0.4488774520137928 1.0 0.7139598222807859 3 Q9BVK6 1 +Golgi vesicle budding 0.6130532183988269 0.7572878106313442 0.4488774520137928 1.0 0.7139598222807859 3 Q9BVK6 1 +Regulation of cellular component size 0.3617268460221348 0.7517132104571387 0.4522235442776772 1.0 0.7174285911150885 71 Q8N0X7,Q9NYL9,P55011,O94813,Q9UQB8,Q9UHB6,P42345,P58546,O15143,O00165,Q15375,P51790,Q9NUQ9 13 +Regulation of immune system process 0.3493151052623264 0.7474936528473805 0.4547656327101892 1.0 0.7207186616722355 144 P05067,O75179,P11279,Q07021,O94813,Q92692,Q99538,P02786,O43657,Q06481,Q99873 11 +Response to bacterium 0.3854392185743456 0.7447947347618842 0.456395818382094 1.0 0.7222870844213388 46 O75179,Q9ULM6,Q8WTV0,Q9UQB8,Q9BTY2,Q9Y263 6 +Regulation of cell cell adhesion 0.4038877063021367 0.7446161433290291 0.456503805965305 1.0 0.7222870844213388 34 Q15375,P02786 2 +Positive regulation of cell cell adhesion mediated by cadherin 0.605503286705126 0.7408435495366725 0.4587883063320461 1.0 0.724104239821534 4 O75955 1 +Regulation of cell cell adhesion mediated by cadherin 0.605503286705126 0.7408435495366725 0.4587883063320461 1.0 0.724104239821534 4 O75955 1 +Negative regulation of small molecule metabolic process 0.456908880931662 0.7351266693893316 0.4622623534965082 1.0 0.7262437638372037 15 Q06481 1 +Neurotransmitter uptake 0.6034417306729947 0.7333713501694209 0.4633319682242156 1.0 0.7271937876969016 4 P05556 1 +Cardiac muscle contraction 0.4565472149090003 0.7333590172418082 0.4633394882467021 1.0 0.7271937876969016 15 P10253 1 +Cell activation 0.3477027795435219 0.7324271233425109 0.4639079087517563 1.0 0.727714902976959 98 P05067,P11279,Q9UQ84,P02786,Q9Y624,Q92542 6 +Positive regulation of cell development 0.3819579710813832 0.7300745260791983 0.4653446314158567 1.0 0.728483828026298 49 Q9Y624,O94813,Q9UQB8,Q07021 4 +Negative regulation of epithelial cell migration 0.4842485211391997 0.7280229854196545 0.4665995159619327 1.0 0.7295483541305926 10 O94813 1 +Cellular response to endogenous stimulus 0.3591271992594186 0.7270549144671493 0.4671923162439777 1.0 0.7298916749845651 179 Q8N0X7,P05067,Q6ZWJ1,Q13177,Q9H4M9,Q9BSK2,P61981,Q99538,O00410,P31751,P54132,Q13573,Q06481,Q13547,Q15185,O94813,Q99523,O15118,Q92542,Q92896,Q6IAA8,Q9H1E3,P05556,Q96A49,O75844,Q9UQB8,Q9Y2U8,Q9UNS1,P20020,P38398,P67870,P42345,P42785,Q9H7B4,O43865,Q13243,O95831 37 +Rho protein signal transduction 0.4378495601150438 0.7236936126729812 0.4692538553668419 1.0 0.7316272442374389 18 Q9Y624,P05556,Q12802 3 +Pyrimidine nucleoside triphosphate biosynthetic process 0.5557473666699754 0.720193796098648 0.4714056831369784 1.0 0.7346101723802521 7 P15531,P23919,Q9NRF8,P17812 4 +Sulfur compound metabolic process 0.3578981336372295 0.7135296610577764 0.4755180656514832 1.0 0.739147874328751 76 P50897,O43505,Q8NCH0,P16278,P15586 5 +Positive regulation of cell cell adhesion 0.4139204787014376 0.7119638258110675 0.4764871767921144 1.0 0.7399962223714214 23 P02786 1 +Plasma membrane organization 0.435573744083444 0.7116770623592947 0.4766647747157799 1.0 0.7399962223714214 18 O75955,Q9UQB8,Q9Y3E7,Q9UNF0,P31751 5 +Positive regulation of behavior 0.6004081632653021 0.7109915475472399 0.4770894736370841 1.0 0.7402822301369776 3 Q96QK1,Q92769 2 +Positive regulation of ion transport 0.4076454940520122 0.7095525837438801 0.4779816322674781 1.0 0.7412929244007211 28 Q9Y4C2,P55011,P05026,P51809,P54709,P08183,P20020,P05556 8 +Regulation of collagen metabolic process 0.599873739488031 0.7090503104151127 0.4782932567314857 1.0 0.7415894187095838 3 P05556 1 +Negative regulation of histone h3 k9 methylation 0.5962208515832224 0.7073341746646421 0.479358832804547 1.0 0.7423976978794892 4 P26358,P38398 2 +Positive regulation of response to biotic stimulus 0.4078978910372559 0.706464430525762 0.4798993651045251 1.0 0.7423976978794892 27 Q92692,P11279,O75179 3 +Peptidyl proline hydroxylation 0.5177407451384282 0.7060759320771784 0.4801409181348264 1.0 0.7423976978794892 8 Q13162,P13674,O15460 3 +Multicellular organismal response to stress 0.5870486113190446 0.7036558402524636 0.4816471273628702 1.0 0.7437926669609208 5 Q04637,P42345,P17655 3 +Regeneration 0.4083164131980078 0.7031154602259018 0.4819837981633212 1.0 0.7441259391403132 24 Q96G23,P11717,Q7Z4V5 3 +Positive regulation by host of viral transcription 0.5866389564830712 0.7021919129912352 0.4825594882508923 1.0 0.7445755160127959 5 Q13573 1 +Positive regulation of molecular function 0.3617015131859211 0.7016074795488181 0.4829239858453209 1.0 0.7448304060244593 225 P05067,Q5JTV8,Q13177,Q4KMP7,O75503,Q8IXB1,Q99538,P02786,P58546,P26583,P40616,P31751,Q15555,Q96AC1,Q9Y263,Q13546,Q13547,Q05639,Q15185,P09429,Q8WTV0,P60900,P05026,Q06787,P54709,Q15375,Q92542,Q16763,P05556,Q9Y4C2,Q96A49,Q12802,P15531,Q9Y624,Q03164,Q15334,Q8WXX5,Q9BRT9,P42345,P84095,P08183,Q92688,O43464,Q12899,O95831 45 +Regulation of heart contraction 0.4213962204806911 0.6963288063126429 0.4862229370667099 1.0 0.7480446335631518 20 P10253 1 +Synaptic vesicle cytoskeletal transport 0.5929997409382813 0.6957903211335704 0.4865601515431779 1.0 0.7483764309396318 4 O14617 1 +Regulation of cellular component movement 0.3337558709409753 0.6943286486928948 0.4874761286061884 1.0 0.7488858481812849 107 P05067,P11279,Q8WTV0,Q07021,O94813,Q14126,P67870,Q99538,Q96G23,P42785,Q9Y263,P05556,Q06481 13 +Negative regulation of calcineurin mediated signaling 0.5924675004242451 0.6938872425430933 0.4877529247104042 1.0 0.7488858481812849 4 P23634,P42345 2 +Negative regulation of calcium mediated signaling 0.5924675004242451 0.6938872425430933 0.4877529247104042 1.0 0.7488858481812849 4 P23634,P42345 2 +Protein folding in endoplasmic reticulum 0.4802435327482715 0.6882506390312576 0.4912949599387453 1.0 0.7523171267662784 9 Q8IXB1 1 +Energy homeostasis 0.5812862801751068 0.6852641309757733 0.4931772618120229 1.0 0.7533790787805262 6 Q13501 1 +Cellular lipid metabolic process 0.3434576703144978 0.6833167357012991 0.4944067212454082 1.0 0.7533790787805262 142 P06865,Q9HB40,Q99519,Q8WTV0,Q8NHP8,P35790,P06280,P07686,P61916,P17900,P04062,P50897,Q06481,P16278,Q13510 15 +Positive regulation of neuron projection development 0.4089886600408134 0.6826691008167564 0.4948159589052168 1.0 0.7533790787805262 23 Q14108 1 +Mesoderm morphogenesis 0.5790089740895139 0.677285352137919 0.4982249227789661 1.0 0.7559033257657931 6 Q16881,P05556 2 +Negative regulation of actin filament polymerization 0.4289831202566454 0.6770171508373712 0.4983950726353761 1.0 0.7559033257657931 18 Q9NYL9,P58546,Q9NUQ9,O94813 4 +Regulation of non motile cilium assembly 0.578823725883152 0.6766372348818971 0.4986361483802162 1.0 0.7559033257657931 6 P27695,Q16181,Q15555 3 +Late endosome to golgi transport 0.5908142164902144 0.6763474442460705 0.4988200767559554 1.0 0.7559033257657931 3 O60493 1 +Positive regulation of type i interferon mediated signaling pathway 0.5279477764177886 0.6750420754420822 0.4996490333487009 1.0 0.7564170936517544 2 P61086 1 +Response to lipid 0.3276471830938474 0.6750397179807015 0.4996505310835935 1.0 0.7564170936517544 113 Q13126,Q8WTV0,O94813,P02786,O15118,Q9H7B4,P04062,O43464,P11717,O95831,Q9Y263,P16278 12 +Negative regulation of transport 0.3728870245407249 0.6729986326242543 0.5009481608349988 1.0 0.7581951391988907 52 P05067 1 +Establishment of mitochondrion localization 0.4712133116796083 0.6725494078097105 0.5012339972479793 1.0 0.7582773304246209 10 Q66K74,Q92692 2 +Microtubule anchoring at centrosome 0.58964029392249 0.6721391838872023 0.501495093306652 1.0 0.7582773304246209 3 Q14203 1 +Microtubule anchoring at microtubule organizing center 0.58964029392249 0.6721391838872023 0.501495093306652 1.0 0.7582773304246209 3 Q14203 1 +Glucan biosynthetic process 0.4756865919656902 0.6694367111769901 0.5032169400747428 1.0 0.7599476821290634 9 Q15185 1 +Calcium ion regulated exocytosis 0.5081598861679663 0.6686016397556336 0.5037496263017291 1.0 0.7603791245745884 8 Q9BRK5 1 +Positive regulation of catalytic activity 0.3470544064705872 0.6667542219487419 0.5049291380059986 1.0 0.760675711954099 154 P05067,Q15185,Q8WTV0,Q4KMP7,Q9BRT9,Q12802,Q99538,Q9Y624,Q15375,O43464,P05556,Q92542,Q92688,Q15334,Q16763,O95831,Q9Y263 17 +Regulation of stress granule assembly 0.5259077927376575 0.6667483985455978 0.5049328583450836 1.0 0.760675711954099 2 Q13283 1 +Response to nitrogen compound 0.3566204650693612 0.6663172235755417 0.505208358893626 1.0 0.760675711954099 189 P05067,P49721,O94813,P08195,Q9UQB8,Q99538,Q99523,Q5VT66,O15118,Q8IXB1,Q9NUD5,Q92542,Q9UNS1,O95831,P35613,Q06481 16 +Tubulin complex assembly 0.584504568757721 0.6655689798127997 0.5056866393732828 1.0 0.7610639546862142 4 O75347,Q15813 2 +Response to food 0.5761965796496584 0.6651146856418404 0.505977142316338 1.0 0.7613132398083368 5 Q9UMX5 1 +Regulation of lipid metabolic process 0.3823113265312516 0.661779022038154 0.5081128523611267 1.0 0.762615379675979 38 Q06481,Q8WTV0,P61916,Q13510 4 +Regulation of establishment or maintenance of cell polarity 0.5752485462467942 0.6617722946634979 0.5081171644399276 1.0 0.762615379675979 5 Q9NUQ9,Q14254,Q15334 3 +Post golgi vesicle mediated transport 0.3936994627103505 0.6610575584487564 0.508575401810877 1.0 0.762615379675979 33 O15127,P11279,Q99523,Q15334 4 +Postsynaptic membrane organization 0.582925519550716 0.6599889305781667 0.5092609329222109 1.0 0.7629379057832869 4 Q15334 1 +Odontogenesis 0.5059327528329411 0.659949644061075 0.5092861446758663 1.0 0.7629379057832869 8 Q13547,Q6P4Q7,P35613 3 +Organelle membrane fusion 0.4302852735332156 0.6585282864007397 0.5101987270786257 1.0 0.7635618771568056 17 Q86Y82,O95721,Q9Y3E7,P51809,Q8IWA4 5 +Cellular response to lipoprotein particle stimulus 0.5821072756989767 0.6571021924121786 0.5111152092958031 1.0 0.7644659279783215 4 O15118 1 +Skeletal muscle tissue regeneration 0.5805070334573728 0.6514661312552182 0.5147456333227798 1.0 0.7683124519680862 4 Q7Z4V5,P58546 2 +Negative regulation of cytoskeleton organization 0.3830776545589328 0.6477419273490519 0.517151881420272 1.0 0.7709695239478487 37 Q9NYL9,Q13177,O94813,Q9UHB6,P58546,Q9Y624,Q9NUQ9,P38398 8 +Cellular response to virus 0.4179032589178785 0.6461475516118859 0.5181838024164782 1.0 0.7719597179078235 19 O43657,O75179,Q07021 3 +Negative regulation by host of viral transcription 0.5785195223668088 0.6444839385179897 0.5192616695092496 1.0 0.7726181969957587 4 Q13547 1 +Positive regulation of execution phase of apoptosis 0.5810788534998568 0.6416644905953995 0.5210910498978361 1.0 0.7737707689401501 3 P63167 1 +Response to tumor cell 0.569196032680384 0.6405323013079464 0.5218265962056812 1.0 0.773777207230668 5 P09429,Q92692 2 +Aspartate transmembrane transport 0.5193798449612393 0.6404065809609439 0.5219083055252933 1.0 0.773777207230668 2 Q9UJS0 1 +Negative regulation of protein serine threonine kinase activity 0.4481660492607066 0.6380450258676473 0.523444370654921 1.0 0.7739113388062512 13 P04062 1 +Sterol biosynthetic process 0.4214586923386174 0.6377287643270173 0.5236502578312234 1.0 0.7739113388062512 18 Q15392,Q9UBM7 2 +Negative regulation of multicellular organismal process 0.3490162384111821 0.6355667260300927 0.5250588627404817 1.0 0.7749363825952119 82 Q9UIQ6,Q07021,O94813,Q99538,Q15375,P04062,Q06481 7 +Ensheathment of neurons 0.4094428085532174 0.6302781266931768 0.5285126313487885 1.0 0.7776203060573127 20 Q96P11,P07686,P31751,Q92542,Q96PU8 5 +Response to endogenous stimulus 0.3567843056343192 0.630206445684708 0.528559522632752 1.0 0.7776203060573127 220 Q8N0X7,P05067,Q6ZWJ1,Q13177,Q9H4M9,Q9BSK2,P61981,Q99538,P26583,P31751,P54132,Q13573,Q96T76,Q06481,P16278,Q13547,Q15185,O94813,Q99523,O15118,Q92542,Q92896,Q6IAA8,Q9H1E3,P05556,Q96A49,O75844,Q9UQB8,O15143,Q9Y2U8,Q15392,P04062,Q9UNS1,P20020,Q9NR50,P38398,P67870,P42345,P42785,Q9H7B4,O43865,Q13243,O95831,P35613 44 +Regulation of cell differentiation 0.3493132335462129 0.6235505198637344 0.5329228144198987 1.0 0.781602648624821 171 P05067,O75179,Q8WUJ1,Q07021,O94813,Q9UQB8,Q99523,Q9Y624,Q15375,Q92688,Q92896,Q06481,Q99873 13 +Positive regulation of protein export from nucleus 0.4595143329906926 0.6234546357533653 0.5329858041181648 1.0 0.781602648624821 10 Q92688,Q9Y3B8,Q9C0E2,P50402 4 +Apical junction assembly 0.4233446036309753 0.623366643929766 0.5330436124046813 1.0 0.781602648624821 17 Q13177,Q16513,Q16625,Q9Y624,O75116,P17612 6 +Regulation of dna binding transcription factor activity 0.368999134557325 0.6213096120078574 0.5343959305922867 1.0 0.7824674779207395 48 Q12899,P05067,P02786 3 +Dendritic spine development 0.404752534260869 0.6194186813400456 0.5356405774523856 1.0 0.784103432090903 21 Q13177,Q06787,O96013,Q9UQB8,Q96HC4,Q9NUL3,Q14444,Q15334 8 +Vacuolar localization 0.4486341451491583 0.618019080817663 0.5365627609304322 1.0 0.7848935421831008 12 Q96AX1,P51809,Q6IAA8 3 +Heart process 0.3939798930003356 0.6170727223202358 0.5371867598348339 1.0 0.7852677954873978 26 P05026,O75844,Q12802,Q14126,P10253,P20020 6 +Positive regulation of chromatin binding 0.5132598939208546 0.6159992362411844 0.537895023873499 1.0 0.7857799441414934 2 O60341 1 +Fat cell differentiation 0.4068269482266782 0.6159394868221986 0.5379344590801356 1.0 0.7857799441414934 20 P31751,Q9BRK5,Q99523,Q96A49 4 +Response to oxygen levels 0.3671914993093862 0.6154000733712083 0.5382905429697615 1.0 0.7859271693300502 50 Q15904,Q9Y487,P02786,P55786,O95831 5 +Histone deubiquitination 0.560493824926424 0.6103089305781558 0.5416571821651699 1.0 0.7893451528025919 5 Q9NPA8 1 +Exocytosis 0.3649871384600466 0.608023088426713 0.5431721609110522 1.0 0.790748617753239 52 P11279,Q06787,O95721,P11233,Q9Y3E7,P51809,Q9BRK5,O43760,O15439,Q15334 10 +Histone h3 k14 acetylation 0.5712396008305828 0.6071407464518925 0.5437575111932966 1.0 0.7909083383928958 3 Q03164 1 +Antigen processing and presentation of endogenous antigen 0.4919010863952806 0.6060091089310138 0.5445087045155563 1.0 0.7914400598919453 8 P10321,Q03519,P01889,Q6P179 4 +Antigen processing and presentation of endogenous peptide antigen 0.4919010863952806 0.6060091089310138 0.5445087045155563 1.0 0.7914400598919453 8 P10321,Q03519,P01889,Q6P179 4 +Production of molecular mediator of immune response 0.389410212464538 0.6046920139830464 0.5453836553921159 1.0 0.7923376985014765 30 P02786 1 +Actin filament bundle organization 0.3806880712470797 0.598170931152431 0.5497258854257598 1.0 0.7958393614296375 35 Q14651,Q07157,Q13177,Q9UQB8,Q9UHB6,Q7Z460,P42345,Q9Y624,P60903,O75116,Q96AC1,P63167,P05556 13 +Protein autoprocessing 0.5566072851324066 0.5969381308659534 0.5505486881051991 1.0 0.7958393614296375 5 O43464 1 +Ras protein signal transduction 0.3653169862366051 0.5958860262619886 0.5512513689199898 1.0 0.7962624255600952 49 Q13501,Q12802,P11233,Q9Y624,Q15392,P05556 6 +Striated muscle contraction 0.4130490617126042 0.5942284577287076 0.552359321514186 1.0 0.7971540537147817 18 P10253 1 +L alpha amino acid transmembrane transport 0.4566533857210769 0.5920247474654856 0.5538340167607865 1.0 0.798023880457796 9 P08195 1 +Dendritic transport 0.5528089413653579 0.5871357768407702 0.5571125211188193 1.0 0.8016960468002848 6 Q00577,Q9NUL3 2 +Peptidyl proline modification 0.3865706479623876 0.5864217190641172 0.5575921525046281 1.0 0.8016960468002848 30 Q9Y680,P13674,Q8WUA2,Q9NWM8,O15460,O00170,P30414,Q9BV86,Q13162 9 +Rna phosphodiester bond hydrolysis 0.3621717613815675 0.5850016487671308 0.5585466081356718 1.0 0.8019989426985381 52 O00584,Q16630,Q9UQ84,Q9Y2L1,Q96C86 5 +Establishment of spindle orientation 0.4449911050302302 0.5835293740489719 0.5595369888261192 1.0 0.8022805698572947 11 Q14203,Q9UNZ2,Q7Z460,P05556,Q15334 5 +Regulation of immune response 0.3377466589688203 0.5825674134240191 0.5601845475136709 1.0 0.8024793529645583 94 O75179,P11279,Q07021,Q92692,Q9NUD5,Q7Z739,P51809,P02786,O43657,Q06481 10 +Negative regulation of protein polymerization 0.3949116767933226 0.5808007342358552 0.5613747601771237 1.0 0.8036785010010983 22 Q9NYL9,O94813,Q9NUQ9,P58546 4 +Negative regulation of b cell activation 0.5042839657282745 0.5807436680914069 0.5614132260525782 1.0 0.8036785010010983 2 O15347 1 +Isoprenoid metabolic process 0.4051116729085201 0.5781894230795341 0.5631362388995478 1.0 0.8054228095079745 19 Q9HB40,P61916 2 +Negative regulation of mrna splicing via spliceosome 0.42974936840766 0.5781616655506696 0.5631549772505815 1.0 0.8054228095079745 14 Q07021 1 +Purine nucleotide transport 0.4528070803848285 0.576638426691754 0.5641837350684602 1.0 0.80633223231581 9 O15439,O43808 2 +Nadph regeneration 0.4525603525054829 0.575654684250521 0.564848610904036 1.0 0.8070951258612554 9 Q13423 1 +Regulation of dna methylation 0.4837434710672804 0.5751465928880419 0.5651921589492619 1.0 0.8072113483299943 8 Q8NB78,Q03164,P38398 3 +Nucleoside diphosphate metabolic process 0.3645633686083602 0.5734524327957544 0.5663383974348273 1.0 0.8080986125159285 40 P05067,P15531,Q9BW91,P17858,P23919 5 +Activation of immune response 0.3749618542505088 0.573118499219524 0.5665644624489712 1.0 0.8082131152201701 36 Q92692,Q06481,Q07021 3 +Positive regulation of programmed necrotic cell death 0.5604784288231068 0.5700495592592838 0.5686440850678927 1.0 0.8091383479923769 3 Q13546 1 +Positive regulation of cell adhesion 0.3639394799807867 0.5690506541313635 0.5693217647725712 1.0 0.8097283681461588 42 Q9Y624,P02786 2 +Negative regulation of response to biotic stimulus 0.4027703288596781 0.5658766752917231 0.5714776185137129 1.0 0.8114824024882219 19 Q7Z739,O43657,Q07021 3 +Tongue development 0.5574528459526444 0.5597554775070379 0.5756462358490835 1.0 0.8146222193495051 3 Q13547 1 +Hair follicle placode formation 0.5574528459526444 0.5597554775070379 0.5756462358490835 1.0 0.8146222193495051 3 Q13547 1 +Fungiform papilla development 0.5574528459526444 0.5597554775070379 0.5756462358490835 1.0 0.8146222193495051 3 Q13547 1 +Fungiform papilla morphogenesis 0.5574528459526444 0.5597554775070379 0.5756462358490835 1.0 0.8146222193495051 3 Q13547 1 +Ectodermal placode development 0.5574528459526444 0.5597554775070379 0.5756462358490835 1.0 0.8146222193495051 3 Q13547 1 +Tongue morphogenesis 0.5574528459526444 0.5597554775070379 0.5756462358490835 1.0 0.8146222193495051 3 Q13547 1 +Cell surface receptor signaling pathway involved in cell cell signaling 0.35725580419924 0.5566232580160939 0.5777848596459592 1.0 0.8162967831207366 54 Q13547,P05067,Q9UQB8,P67870,P48729,Q99471,P50402,Q15334,Q96AC1,O00571 10 +Positive regulation of necrotic cell death 0.5523207527543266 0.554474447786733 0.5792541882398994 1.0 0.8170602604795099 4 Q13546 1 +Oligodendrocyte development 0.4777690709662313 0.5528008207371182 0.5803998064452889 1.0 0.8177394984630764 8 Q9NR50,Q92542 2 +Membrane protein ectodomain proteolysis 0.4772393204133305 0.5508304662011393 0.5817498971471007 1.0 0.817762163379373 8 Q92542 1 +Positive regulation of innate immune response 0.3829471642785598 0.5507249064907522 0.5818222682714722 1.0 0.817762163379373 24 Q92692,P11279 2 +Chaperone cofactor dependent protein refolding 0.4329914698391072 0.5502376515947032 0.5821563819225684 1.0 0.8177816206929622 12 P48723 1 +Response to retinoic acid 0.4410327559028992 0.5475195772962552 0.584021824285009 1.0 0.8183306440542185 10 P11717,P02786 2 +Positive regulation of dopamine receptor signaling pathway 0.4953080375357021 0.5461837899148949 0.584939607679489 1.0 0.8183306440542185 2 Q96QK1 1 +Regulation of dopamine receptor signaling pathway 0.4953080375357021 0.5461837899148949 0.584939607679489 1.0 0.8183306440542185 2 Q96QK1 1 +Golgi ribbon formation 0.495308037535702 0.5461837899148947 0.5849396076794893 1.0 0.8183306440542185 2 Q8IWJ2 1 +Regulation of bone mineralization 0.552009732722586 0.5413927473373698 0.5882369051283287 1.0 0.8197769635299049 3 O75844 1 +Cellular component assembly involved in morphogenesis 0.4065040437305779 0.5393876755042298 0.5896193832451373 1.0 0.8204395100891048 17 Q9NYL9,Q92692,P05556,Q16527 4 +Positive regulation of mitotic cell cycle phase transition 0.3796974041190915 0.537391766914257 0.5909970291324811 1.0 0.8212071108934069 29 P05067,O75179 2 +Dna methylation 0.415297599125358 0.5362706307318832 0.5917715252451483 1.0 0.8219491834543934 15 Q8NB78,P38398,Q03164,O75844 4 +Establishment of mitotic spindle localization 0.4288700312983539 0.5326578216500821 0.5942704682966369 1.0 0.8242674641366058 12 O75122,Q14203,Q9UNZ2,Q7Z460,Q14974,P05556 6 +Carbohydrate derivative metabolic process 0.3492061264758465 0.5323867703496393 0.594458146113158 1.0 0.8243420733375482 207 P05067,P06865,Q99519,Q13126,P06280,P07686,O15118,Q9BTY2,P17900,P04062,P50897,P54802,Q92542,O43505,P08236,Q8NCH0,P16278,P15586 18 +Homeostasis of number of cells 0.3579572694672332 0.5310478678177774 0.59538560873278 1.0 0.8248258201928015 47 Q9NYL9,P08708,Q9ULM6,P49069,P26583,P04062,Q15020,Q92542,Q14157,P38571,Q99873 11 +Regulation of reproductive process 0.4193348820078811 0.5309162472913164 0.5954768183785939 1.0 0.8248258201928015 14 Q7Z739,P35579,Q13162,Q07021 4 +Homocysteine metabolic process 0.4904120767033942 0.527647248076445 0.5977441930509197 1.0 0.8268449321964847 2 Q13867 1 +Sulfur amino acid catabolic process 0.4904120767033942 0.527647248076445 0.5977441930509197 1.0 0.8268449321964847 2 Q13867 1 +Cellular macromolecule localization 0.2915836591087521 0.5276038194092945 0.5977743415171881 1.0 0.8268449321964847 425 P02786,O60830,Q5J8M3,Q14108,Q06481,P11279,Q15904,P10619,Q99523,O14773,O15118,Q13501,Q99595,Q9Y624,Q9UI26,Q9HD45,Q8N4H5,Q5W0Z9,O75436,P11233,Q8N4V1,Q92688,O43464,O95831,P35613,Q9Y282,P55786,O95373,Q8TEX9,Q5MNZ6,Q99747,O00170,P05556,P27348,Q96AX1,Q9HD20,Q86Y82,O14925,Q5SRE5,Q15334,Q9BZH6,P84095,Q7Z6Z7,Q9UH62,Q9C0E2,Q9H4M9,P31751,Q9Y6C9,Q9BVK6,P05026,Q969Q5,P54709,P24390,O96008,Q6IAA8,Q9NS69,Q9Y4C2,Q7Z3T8,P49069,Q68CQ4,Q9BW83,Q76FK4,Q9Y678,O00165,O43865,P35606,P50402,Q9H8Y8,Q96CS3,Q6ZWJ1,Q5JTV8,P61981,P55060,O00410,P40616,Q15555,Q96AC1,O15258,O75955,P49755,Q9Y5K6,Q8NFH5,P48444,O00571,P49458,P61020,Q14254,Q96P70,Q4J6C6 89 +Metal ion export 0.5024311972033357 0.5274594689947544 0.5978745554878593 1.0 0.8268449321964847 7 P54709,P05026 2 +Cellular response to biotic stimulus 0.3785051217039232 0.5263226320210406 0.5986640608452976 1.0 0.827303099660657 28 Q8WTV0,O75844,P26583,Q9UM00,Q9NUQ9,Q9Y263 6 +Negative regulation of muscle cell differentiation 0.4356945291268863 0.5260151419001204 0.5988776864036947 1.0 0.827303099660657 10 O75179 1 +Regulation of chromatin binding 0.547065202018553 0.524892981533476 0.5996575886831055 1.0 0.8280814183044697 3 Q7Z5K2 1 +Cellular response to molecule of bacterial origin 0.3899812723956224 0.5248174592125603 0.5997100932628927 1.0 0.8280814183044697 20 Q9NUQ9,Q8WTV0,Q9Y263,P26583 4 +Regulation of cytoskeleton organization 0.3263867065896049 0.5242956249490474 0.600072939404042 1.0 0.8283966564822168 101 Q13177,Q13045,Q9UHB6,P17655,P58546,Q15555,Q96AC1,P62993,Q9NYL9,O94813,Q14247,Q9Y5K6,Q9NUL3,Q66K74,Q12802,Q9UQB8,Q14203,Q9UHV9,Q9Y624,O15143,P38398,Q9Y3E7,Q14019,Q15691,P42345,Q16625,O00165,P84095,P60903,Q9NUQ9 30 +Positive regulation of cellular component organization 0.3467684509805391 0.523669803210247 0.6005082219109399 1.0 0.8284871355564792 193 P05067,P11233,O94813,Q9UQB8,P49427,P02786,P04062,P50897,Q14108,Q06481 10 +Positive regulation of histone h3 k4 methylation 0.4387069735619466 0.5210911194063609 0.602303297061991 1.0 0.8298011635736583 9 Q03164,P38398 2 +Cardiocyte differentiation 0.3981609410194185 0.5184868063508203 0.6041186630547362 1.0 0.8311314004930811 18 Q12802,P05556,Q96HC4,O75844 4 +Protein localization to synapse 0.4334516981716767 0.5170435870083302 0.6051257323824157 1.0 0.8318283398701795 10 Q9UQB8 1 +Pyrimidine deoxyribonucleoside monophosphate biosynthetic process 0.5444655771666445 0.5162896090394649 0.605652152497488 1.0 0.8319947128351258 3 P33316 1 +Dtmp metabolic process 0.5444655771666445 0.5162896090394649 0.605652152497488 1.0 0.8319947128351258 3 P33316 1 +Pyrimidine deoxyribonucleoside monophosphate metabolic process 0.5444655771666445 0.5162896090394649 0.605652152497488 1.0 0.8319947128351258 3 P33316 1 +Positive regulation of small gtpase mediated signal transduction 0.5309084681487608 0.5145140987011297 0.6068926058399571 1.0 0.8329553665083851 6 Q9Y624,Q12802 2 +Regulation of response to interferon gamma 0.4867401060791594 0.5138980900712585 0.607323242903298 1.0 0.833106591308436 2 P08238 1 +Membrane repolarization 0.4668818629741356 0.5126901208644019 0.6081681013295115 1.0 0.833910026726613 8 P54709,P05026 2 +Extrinsic apoptotic signaling pathway via death domain receptors 0.427930056806275 0.5125510843464475 0.6082653776237159 1.0 0.833910026726613 11 Q99523,P26583,P38398 3 +Circadian regulation of gene expression 0.4096587097408001 0.5102238497913191 0.6098946452200289 1.0 0.8356230702871295 15 Q03164,Q9Y2K7,Q7Z6Z7 3 +Non lytic viral release 0.5425963266088912 0.5101345934870222 0.6099571710207163 1.0 0.8356230702871295 3 Q9Y3E7 1 +Regulation of oxidative phosphorylation 0.4971498390898283 0.5092423190149135 0.6105823833075434 1.0 0.8359696984711018 7 P14406 1 +Endothelium development 0.3960448144057867 0.5078721219419747 0.6115430266644504 1.0 0.8366332477471665 18 Q9Y624,O60568,P67870 3 +Activation of cysteine type endopeptidase activity involved in apoptotic process 0.4265145416226588 0.5067590146182875 0.612323917090251 1.0 0.8368653401830578 11 Q92688 1 +Regulation of trans synaptic signaling 0.3543950489191229 0.5033662471649415 0.6147067977232314 1.0 0.8387971466085209 47 Q13501,P05067,Q99538,Q92542 4 +Trna aminoacylation for mitochondrial protein translation 0.5274141173659942 0.5031948668201472 0.6148272734520472 1.0 0.8387971466085209 6 Q9BW92,Q9NP81,Q9Y2Z4,P41250 4 +Establishment of lymphocyte polarity 0.5401964996944849 0.502271461466681 0.6154765810824985 1.0 0.8392057443338724 3 Q14254 1 +Central nervous system neuron differentiation 0.420816978620689 0.4986851113165225 0.6180012350283242 1.0 0.8410772776457541 12 O94813,P58546 2 +Hematopoietic stem cell proliferation 0.5350934961305489 0.4976356245937139 0.6187408895576771 1.0 0.8416630948142879 4 P04062 1 +Cellular response to insulin stimulus 0.3539136409756263 0.4942461479287978 0.6211323521412211 1.0 0.8436602453416057 40 Q6ZWJ1,Q96A49,Q9BSK2,Q9UQB8,P20020,P31751,Q13243,Q9H1E3,Q06481 9 +Regulation of cellular component biogenesis 0.3401659498888059 0.4921325911303611 0.6226256139253037 1.0 0.8449428928671137 174 P05067,Q13177,Q4KMP7,Q13045,Q5T3I0,P02786,P58546,Q15555,Q96AC1,Q9NYL9,P09429,O75955,Q06787,O94813,Q9NQW6,Q96HC4,Q9NUL3,Q15375,Q9H2G2,Q9ULM6,Q9UQB8,Q14203,Q9Y624,O15143,P04062,P51114,P38398,P11233,Q9Y3E7,P49427,P42345,O00165,P84095,Q9NUQ9 34 +Negative regulation of amyloid precursor protein catabolic process 0.5234739209024538 0.490527339139005 0.6237607888375944 1.0 0.8457797018794188 6 P49755,Q14254,P27695 3 +Regulation of protein maturation 0.4259639617928709 0.4873795645888557 0.6259893726127048 1.0 0.8468944335698579 10 P20810,P35579,Q92896 3 +Positive regulation of mitochondrion organization 0.390972046420128 0.4825975059684569 0.6293815503193116 1.0 0.8496167957281302 18 P11233 1 +Regulation of epithelial to mesenchymal transition 0.4883765283084126 0.479408999720764 0.6316476922676819 1.0 0.8511549124605795 7 Q96AC1,P42345,Q92769,Q7Z460 4 +Spermatid differentiation 0.3976251084035836 0.4793361975067173 0.6316994749601141 1.0 0.8511549124605795 16 Q92692,Q14997,P26583,A0AVF1,Q96PU8,P17612,P62826 7 +Execution phase of apoptosis 0.4189025379107037 0.4758934470169227 0.6341502909343781 1.0 0.8530616869746485 11 O43464 1 +Embryonic body morphogenesis 0.5315987599963619 0.4744718789494503 0.6351634465537865 1.0 0.8536785287997519 3 Q7Z460 1 +Positive regulation of nuclease activity 0.5309501061446981 0.4723987784373389 0.6366421761256853 1.0 0.8540684984226702 3 P26583 1 +Cop9 signalosome assembly 0.4753161974704203 0.4720116068706753 0.63691850388365 1.0 0.8540684984226702 2 Q99627 1 +Regulation of hormone levels 0.3507666660565631 0.4718855714783506 0.6370084673510732 1.0 0.8540684984226702 45 Q9HB40,P42892,Q9UBM7 3 +Regulation of muscle organ development 0.5174737650120342 0.4714396260601201 0.6373268240348355 1.0 0.8540684984226702 6 P58546 1 +Negative regulation of supramolecular fiber organization 0.3534406049074327 0.4711490194067123 0.6375343217070963 1.0 0.8540684984226702 39 Q9NYL9,Q13177,O94813,Q9UHB6,P58546,Q9Y624,Q99471,Q9NUQ9 8 +Vesicle mediated transport to the plasma membrane 0.3647081805640459 0.4678924689831812 0.6398614893427723 1.0 0.8562545511591935 33 Q15334,O75436,Q15904,Q9H4M9 4 +Oligodendrocyte differentiation 0.3878269886450939 0.467054871979214 0.6404606201143865 1.0 0.8565764513640426 18 Q13547,Q96P11,Q92542,Q9NR50 4 +Cardiac cell development 0.4090286549574517 0.4659844689073449 0.641226617585068 1.0 0.8565764513640426 13 Q12802,Q96HC4,O75844 3 +Regulation of action potential 0.4533820739938381 0.464165508407632 0.6425291708011549 1.0 0.8568447270137992 8 Q14126 1 +Response to x ray 0.4119174240771873 0.4617733046508173 0.6442438965239086 1.0 0.8580160077962914 12 Q70UQ0,P54132 2 +Locomotion 0.3382847197291173 0.4602947346313831 0.645304680048921 1.0 0.8580160077962914 176 P05067,Q99538,Q9UHB6,P42892,Q9Y263,Q06481,Q8WTV0,O94813,P07686,Q96G23,Q15375,P05556,P55011,Q9ULM6,Q7Z739,Q9Y624,P04062,Q07021,P11233,P67870,P42785,P35613 22 +Regulation of cellular carbohydrate metabolic process 0.37308603128463 0.4590514258100186 0.646197237100788 1.0 0.8582045704981777 22 Q14108,P31751,O75844,O00763 4 +Subpallium development 0.4712362301101612 0.4573954047149865 0.6473868667057769 1.0 0.8589500020055532 2 P00492 1 +Striatum development 0.4712362301101612 0.4573954047149865 0.6473868667057769 1.0 0.8589500020055532 2 P00492 1 +Pyrimidine ribonucleoside triphosphate biosynthetic process 0.5140927087363827 0.4567468630329238 0.6478530029211353 1.0 0.8589500020055532 5 P15531,Q9NRF8 2 +Pyrimidine ribonucleoside triphosphate metabolic process 0.5140927087363827 0.4567468630329238 0.6478530029211353 1.0 0.8589500020055532 5 P15531,Q9NRF8 2 +Collagen fibril organization 0.4510528308299651 0.4559407089418231 0.6484326147997095 1.0 0.8589500020055532 8 Q92791,O60568 2 +Negative regulation of amyloid fibril formation 0.5213827003413534 0.4539503373610861 0.6498645719530374 1.0 0.8599665102724598 4 Q99471 1 +Physiological cardiac muscle hypertrophy 0.5118504376411182 0.4537817773947547 0.6499859006076267 1.0 0.8599665102724598 6 Q12802 1 +Dna topological change 0.5115803774986288 0.4529395597574544 0.6505922637997104 1.0 0.8605148374253097 6 Q02880,P26583 2 +Cellular component maintenance 0.4206817571724772 0.4523240486691347 0.6510355536387542 1.0 0.8609162164419695 9 Q14203,Q15334,Q9BRK5 3 +Multicellular organismal signaling 0.3688199940230143 0.4505627767627589 0.6523046995826451 1.0 0.861299600113735 23 P05026,O75844,Q06787,Q14126,P04062,P20020 6 +Regulation of regulated secretory pathway 0.396419206035449 0.4501853597057739 0.6525767918072587 1.0 0.8613349812736818 15 P11279,P51809 2 +Regulation of generation of precursor metabolites and energy 0.3656066967064912 0.4501375177126437 0.6526112859577271 1.0 0.8613349812736818 29 P05067,P14406,Q9BSK2 3 +L amino acid transport 0.4162434571720261 0.4495790854920007 0.6530139713701362 1.0 0.8616152936702403 10 P08195 1 +Exonucleolytic catabolism of deadenylated mrna 0.4490961368737105 0.4490668482677424 0.6533834344886067 1.0 0.8616152936702403 8 Q96C86,Q9ULM6,Q9Y2L1,Q15024 4 +Smooth muscle contraction 0.5111049004140121 0.4473736810479004 0.6546052754653329 1.0 0.8623420715302147 5 P20020,Q14247,O75116 3 +Programmed cell death 0.3043783857301146 0.4471982962339034 0.6547318914503171 1.0 0.8623420715302147 344 P05067,Q9UHX1,Q8IXB1,Q99538,P02786,P50897,Q5J8M3,P11717,P13693,Q658P3,P11279,O94813,Q99523,Q15375,Q92542,Q66K74,P05556,Q13510,Q13501,Q15392,P04062,O95881,Q03164,O15269,P38398,Q9BZZ5,Q9P032,Q07021,Q9Y3E7,Q9NXR7,P49427,Q01105,Q92688,O43464,Q96C86,O95831 36 +Negative regulation of neuron projection development 0.3905765563771474 0.4466048578001808 0.6551603875347976 1.0 0.8624989779800739 16 Q15375 1 +Positive regulation of transporter activity 0.395232356999165 0.4448865866359794 0.6564017165257539 1.0 0.8635609762070654 15 Q03164,P54709,P08183,P05026 4 +Protein nitrosylation 0.5221354267788959 0.444578805086701 0.6566241671880544 1.0 0.8635726442656227 3 P23634 1 +Positive regulation of wound healing 0.5081476014579298 0.4422814152815499 0.6582855777049308 1.0 0.8652416365120515 6 Q96AC1,P05556,P42345 3 +Positive regulation of protein targeting to membrane 0.5077004421428304 0.4408996052063569 0.6592856794924531 1.0 0.8653210971591 6 P31751 1 +Non motile cilium assembly 0.4139763033063143 0.4408860305598176 0.6592955073330651 1.0 0.8653210971591 10 P27695,Q14203,Q15691,Q15555 4 +Histone h4 k16 acetylation 0.4767262591057389 0.4406839140414905 0.6594418436194609 1.0 0.8653210971591 7 Q03164,P38398 2 +Cellular response to corticosteroid stimulus 0.4100183413240793 0.4405115383126351 0.6595666572953802 1.0 0.8653210971591 11 Q9H7B4,P20020,O95831,Q13185 4 +Regulation of protein targeting to membrane 0.4759201210632174 0.4380442235144307 0.6613542258505194 1.0 0.8672966919194137 7 P31751 1 +Cell migration involved in sprouting angiogenesis 0.5065364772345985 0.4373098798617056 0.6618866312025786 1.0 0.8677497650011204 6 O94813 1 +Response to platelet derived growth factor 0.5063418490453118 0.4367106501716605 0.66232120450245 1.0 0.8677497650011204 6 Q13547 1 +L aspartate transmembrane transport 0.5195918367346889 0.4366762482894795 0.6623461568857445 1.0 0.8677497650011204 3 Q9UJS0,Q15758 2 +Cell cell signaling 0.3201752367989127 0.4362097952532663 0.6626845217275528 1.0 0.8677497650011204 134 Q13501,P05067,Q9UIQ6,Q9UQB8,Q99538,P50897,P51790,Q92542 8 +Regulation of mrna binding 0.5061783146103856 0.4362073785571032 0.6626862749773053 1.0 0.8677497650011204 6 Q04637,Q86X55,Q06787 3 +Positive regulation of dna recombination 0.3630435073148732 0.4350710426246213 0.6635108615309657 1.0 0.8684601136152542 24 P35637,Q9UNS1,P02786,Q7Z4V5 4 +Sprouting angiogenesis 0.4116776872678658 0.432122304419219 0.6656525246109544 1.0 0.8707466273770404 10 O94813 1 +Homotypic cell cell adhesion 0.3872752662615156 0.4314531085040531 0.666138941078225 1.0 0.8708259030833053 16 Q14126 1 +Positive regulation of secretion 0.3609398070046022 0.4297834414357022 0.6673531791147753 1.0 0.8720062656641917 31 P55011,P30626,P11279,O75122,P49755,P51149,P51809,Q7Z460,Q9Y5K6,O00429,P22059,P35580 12 +Regulation of microtubule nucleation 0.5128564715599794 0.4275484198702271 0.6689799257881077 1.0 0.8726502972621567 4 Q14203 1 +Positive regulation of microtubule nucleation 0.5128564715599794 0.4275484198702271 0.6689799257881077 1.0 0.8726502972621567 4 Q14203 1 +Positive regulation of mitochondrial membrane potential 0.5127549651451488 0.427237818435804 0.6692061183621232 1.0 0.872760447099257 4 Q8IWA4 1 +Negative regulation of cilium assembly 0.5155102040816277 0.4241165864308358 0.6714807896927661 1.0 0.8742455534232102 3 P50570,P50395 2 +Nls bearing protein import into nucleus 0.412980579776596 0.4238236749148213 0.671694410791458 1.0 0.8743387922289655 9 Q8NFH5,P52294,O00410 3 +Regulation of biomineralization 0.5112660279816635 0.4226920772072425 0.6725199368272943 1.0 0.8750433751153107 4 P20020,O75844 2 +Extracellular matrix assembly 0.510875667773026 0.4215035039077246 0.6733874531135751 1.0 0.8758740952895662 4 O60568,Q7Z460 2 +Mitochondrion organization 0.327001142282977 0.4193266924047844 0.6749773914768475 1.0 0.8767586074520992 152 P14406,Q9BSK2,Q92692,P02786,O75153,O60830,P55786,Q5MNZ6,Q8IWA4,O00170,Q13501,Q99595,O14925,P04062,Q8N4H5,Q7Z6Z7,Q9UG56,Q9P032,P11233,O43464,Q9UH62,O95831 22 +Immune system development 0.314034294230373 0.4189492627771119 0.6752532131251077 1.0 0.8769318779184324 125 P05067,Q9NYL9,Q96AX1,Q9ULM6,Q15904,Q9UQ84,P02786,P01889,P04062,P05556,Q99873,Q14739 12 +Positive regulation of transcription from rna polymerase ii promoter in response to stress 0.4589963280293774 0.4147103314318091 0.6783539682954032 1.0 0.8794760434448138 2 P04637 1 +Necrotic cell death 0.3927965093218616 0.4147089233073359 0.6783549992397955 1.0 0.8794760434448138 14 Q13510,Q96HS1,P06737,Q13546 4 +Cellular response to alcohol 0.4000993928162903 0.4139015891732923 0.6789461800023373 1.0 0.8798998613970531 12 O95831,P54132,P38398 3 +Regulation of defense response to virus 0.3965315861647862 0.4137638767979115 0.6790470413879968 1.0 0.8798998613970531 13 O43657 1 +Positive regulation of cell morphogenesis involved in differentiation 0.3686556457147081 0.4132868683058945 0.679396449745264 1.0 0.8798998613970531 20 Q9UQB8 1 +Positive regulation of atp dependent activity 0.3798847820967908 0.4116754302430573 0.6805773359710245 1.0 0.880688242449264 17 Q5JTV8,P05026,Q8IXB1,P54709,Q8WXX5 5 +Regulation of substrate adhesion dependent cell spreading 0.3914649738996013 0.4090634447328007 0.6824931019609006 1.0 0.8826108020947837 14 Q96AC1,Q07021 2 +Response to temperature stimulus 0.3418540822927198 0.4063719779186604 0.6844693060119595 1.0 0.884609050612014 40 Q99543,O60884,Q13217,O43464,P20020,Q06481,Q9NR50 7 +Lung cell differentiation 0.5091522968358568 0.4048589633891182 0.6855811842042727 1.0 0.8854884311193009 3 Q13155 1 +De novo protein folding 0.3808878625628544 0.4024838161797479 0.6873279964860082 1.0 0.8871734336173772 16 Q15185,P48723 2 +T cell mediated immune response to tumor cell 0.5080709871872947 0.401621805903825 0.6879623793011456 1.0 0.8874469661339102 3 P09429 1 +Programmed necrotic cell death 0.3933721262683824 0.4008185840037677 0.68855369545221 1.0 0.8880236914326052 13 Q13510,Q96HS1,P06737,Q13546 4 +Regulation of ossification 0.5038254517781319 0.4002703201008169 0.6889574259027142 1.0 0.8883582976508925 4 P20020,O75844 2 +Pyrimidine nucleoside triphosphate metabolic process 0.406182032081973 0.3991494724420549 0.6897830710843067 1.0 0.888864455560083 9 P15531,P17812,P23919,Q9NRF8,P33316 5 +Establishment of endothelial intestinal barrier 0.4634635212910654 0.3979561692497561 0.6906624949143965 1.0 0.8892643932989124 7 Q9Y624 1 +Exit from mitosis 0.3983789692537398 0.3953142450487345 0.6926109877602997 1.0 0.8908305518362577 11 O75122,Q9UJX2,Q9NQW6,Q7Z460,Q8WUX9,Q16763 6 +Maintenance of dna repeat elements 0.5016564685133273 0.3938288026422188 0.6937074379604522 1.0 0.8916185830416585 4 O75844 1 +Positive regulation of protein containing complex assembly 0.3401867819434706 0.3920703503909691 0.6950062342092249 1.0 0.8924034852639049 44 P02786 1 +Potassium ion transport 0.3782622130581999 0.3907148168116481 0.69600804551523 1.0 0.8924034852639049 16 P55011,P05026,P05556 3 +Response to cytokine 0.3142877473831824 0.388773708583449 0.6974435513435118 1.0 0.893503576191916 130 P05067,O94813,P67870,P49427,P02786,P04062,Q06481,Q13510 8 +Membrane protein proteolysis 0.4000743817113401 0.3886932410784879 0.6975030828222901 1.0 0.893503576191916 10 Q92542 1 +Neuronal stem cell population maintenance 0.50367346938775 0.3885735528371839 0.6975916340351698 1.0 0.893503576191916 3 Q15154,Q9NZI8 2 +Positive regulation of response to wounding 0.4601831436750965 0.3876276283086259 0.6982916200582525 1.0 0.8939581340194742 7 Q96AC1,P05556,P42345 3 +Toxin transport 0.3963302508686279 0.3875053761061948 0.6983821056738138 1.0 0.8939581340194742 11 Q93050 1 +Nucleus localization 0.3960531682770637 0.3864527758797193 0.6991613705380757 1.0 0.8944903383109075 11 Q5SNT2,Q14203 2 +Autophagy of mitochondrion 0.3551218281348743 0.38525835899305 0.7000460095995082 1.0 0.8950169430308808 28 Q13501,P04062,Q5MNZ6,O43464 4 +Negative regulation of muscle organ development 0.4500203998368108 0.3845862280394898 0.7005439992218845 1.0 0.8950169430308808 2 Q8IXJ6 1 +Negative regulation of muscle tissue development 0.4500203998368108 0.3845862280394898 0.7005439992218845 1.0 0.8950169430308808 2 Q8IXJ6 1 +Cell migration 0.3238256255142117 0.3844183654085188 0.7006683906920803 1.0 0.8950169430308808 151 P05067,Q99538,Q9UHB6,Q9Y263,Q06481,Q8WTV0,O94813,P07686,Q96G23,P05556,P55011,Q9ULM6,Q7Z739,Q9Y624,P04062,Q07021,P67870,P42785,P35613 19 +Cellular response to organic cyclic compound 0.3218499775584991 0.3837505051259581 0.7011633755631577 1.0 0.8950169430308808 89 P05067,Q9NUD5,O15118,Q9H7B4,P54132,Q92542,O95831 7 +Positive regulation of meiotic nuclear division 0.4496124031007847 0.383241816926321 0.7015404751240617 1.0 0.8952092653552016 2 Q8IXJ6 1 +Convergent extension 0.4487964096287328 0.3805596246636409 0.7035300456108282 1.0 0.896597904894833 2 Q13263 1 +Axis elongation 0.4487964096287328 0.3805596246636409 0.7035300456108282 1.0 0.896597904894833 2 Q13263 1 +Second messenger mediated signaling 0.36196863754285 0.3794195117900878 0.7043763635582776 1.0 0.896597904894833 20 P49427,Q9ULM6,P05026,O75844 4 +Positive regulation of establishment of protein localization to mitochondrion 0.3909310979171634 0.3777646232671133 0.7056054562173828 1.0 0.897049926477478 12 P55786,O43464 2 +Dna methylation or demethylation 0.3655238870915211 0.3770323655281324 0.7061495525813584 1.0 0.8973710619697468 19 Q8NB78,P38398,Q03164,O75844 4 +Response to virus 0.3217924758882622 0.3766681839674368 0.7064202097918364 1.0 0.8975297630392771 70 O75179,Q9P032,Q06787,Q07021,Q9NUD5,Q9Y3E7,P61916,Q13217,Q12899,O43657,P13693 11 +Response to mineralocorticoid 0.4858327757824566 0.3752803926966255 0.707451946715079 1.0 0.8980993063762354 6 P20020,O95831 2 +Regulation of lymphocyte activation 0.3371178034001132 0.3702381029241162 0.7112050885266572 1.0 0.9011629357381143 42 P02786 1 +Cell junction maintenance 0.4545345085243178 0.3700775566977076 0.7113247039933168 1.0 0.9011629357381143 7 Q14203,Q15334,Q9BRK5 3 +Regulation of stem cell proliferation 0.4853987191067413 0.3698257633076247 0.7115123177568585 1.0 0.9012099034003246 5 Q96AC1,P26583 2 +Neuroepithelial cell differentiation 0.496957649781339 0.3690170487670827 0.7121150171395727 1.0 0.9013072093181276 3 Q9P287 1 +Positive regulation of membrane potential 0.4849634423335904 0.3685636270642461 0.7124530111203851 1.0 0.9013072093181276 5 Q8IWA4 1 +Regulation of map kinase activity 0.385302495431914 0.36826683763365 0.7126742773536598 1.0 0.9013836330457032 13 P04062 1 +Positive regulation of epithelial to mesenchymal transition 0.4846470888482953 0.3676474486290124 0.7131361300123773 1.0 0.9015973619068188 5 Q96AC1,P42345 2 +Negative regulation of molecular function 0.3259631166076254 0.3670531568115843 0.7135793676197568 1.0 0.9019725244169252 160 P05067,P06280,O94813,Q99523,Q9Y624,Q9H7B4,Q15392,P04062,Q06481 9 +T cell activation 0.3365772922779986 0.3663493009816151 0.7141044458608086 1.0 0.9019958639894536 42 Q92542,P02786 2 +Positive regulation of type i interferon production 0.3771962511611654 0.3662883528512169 0.7141499196949557 1.0 0.9019958639894536 15 O75955,Q9NUD5,P26583,O14802,O00571 5 +Fatty acid transmembrane transport 0.483181877001053 0.3634165222360788 0.7162937613172851 1.0 0.9033635166797468 5 O43772,P31751 2 +Regulation of exocytosis 0.3504473634059981 0.3614697921286749 0.7177482829708868 1.0 0.9033762758280466 30 P11233,P11279,P51809,Q9Y3E7 4 +Nuclear ncrna surveillance 0.4942149235094421 0.3611625042838352 0.7179779702845417 1.0 0.9033762758280466 3 Q15024 1 +Regulation of cell adhesion 0.3192534183561753 0.3607446496543574 0.7182903434431518 1.0 0.9033762758280466 68 Q9Y624,Q15375,P02786 3 +Maintenance of synapse structure 0.4822338409440653 0.360689925805531 0.7183312565214199 1.0 0.9033762758280466 5 Q15334,Q9BRK5 2 +Regulation of rna binding 0.4227850822086882 0.3600703563386731 0.7187945202679957 1.0 0.9033762758280466 8 Q9H1E3,Q06787 2 +Positive regulation of gliogenesis 0.4788792825302342 0.3552732062032912 0.7223849262370126 1.0 0.9056993333267594 6 Q13547,P42345 2 +Cerebellar cortex formation 0.4803288645134463 0.3552373368237709 0.7224117956744707 1.0 0.9056993333267594 5 P04062 1 +Lipoprotein biosynthetic process 0.3905784847275729 0.3542342806989212 0.7231633147612215 1.0 0.9060923896146408 10 Q5W0Z9,P04062 2 +Cellular response to leucine starvation 0.4917092469906384 0.3540553850325938 0.723297376727918 1.0 0.9060923896146408 3 P42345 1 +Response to oxygen containing compound 0.3370162865304313 0.3516819496479671 0.725076798970224 1.0 0.9073538389723496 220 P05067,Q13126,Q99538,P02786,P54132,P11717,Q06481,P16278,Q8WTV0,O94813,Q99523,Q92542,Q9UQB8,Q9BRK5,P04062,Q9UNS1,Q9H7B4,O43464,Q96C86,O95831,P35613 21 +Negative regulation of leukocyte mediated immunity 0.4864862339851195 0.3500321303912854 0.7263145845460048 1.0 0.9076025780287004 4 P01889 1 +Mitophagy 0.376941670753029 0.3488328426695823 0.7272148054280629 1.0 0.9076025780287004 14 Q13501,O43464 2 +Negative regulation of mrna processing 0.3628937406275365 0.347863015598379 0.7279430618772618 1.0 0.907827715612376 18 Q07021 1 +Sodium ion homeostasis 0.4757382869386134 0.3463809947421802 0.7290564061269851 1.0 0.9086640268266896 6 P55011,P05026 2 +Sperm capacitation 0.4377804977560164 0.3452372493851417 0.7299160173167367 1.0 0.9091832730364452 2 P17612 1 +Negative regulation of rna splicing 0.3721378226478981 0.3449559592045582 0.7301274802272097 1.0 0.909262721634088 15 Q07021 1 +Regulation of synaptic vesicle recycling 0.4761909277682422 0.3435156426914875 0.7312105748313837 1.0 0.9102596387254522 5 Q9Y263 1 +Positive regulation of protein localization 0.3111541400500954 0.3434982249146208 0.7312236760006638 1.0 0.9102596387254522 100 Q9C0E2,P02786,O00410,O00429,P31751,Q9Y282,P55786,Q96AC1,P62826,Q14651,O15258,P49755,Q9Y3B8,Q9Y5K6,O00264,O75116,P35580,P05556,Q13501,Q9Y4C2,Q9NR31,P22059,Q7Z6Z7,Q15334,P30626,P84095,Q92688,O43464,P50402 29 +Multivesicular body organization 0.4738179033869085 0.3409899973455315 0.7331111119285136 1.0 0.911698584553162 6 Q9Y3E7,Q8WUX9,P53990,Q99816 4 +Interferon gamma mediated signaling pathway 0.4869387755101992 0.3407086541532544 0.7333229230120422 1.0 0.911698584553162 3 P08238,P04637 2 +Viral budding 0.475121027118611 0.340512514234254 0.7334706002603681 1.0 0.911698584553162 5 Q9Y3E7,Q8WUX9 2 +Aromatic amino acid family metabolic process 0.4822381012390787 0.3381786436240929 0.7352285686723463 1.0 0.9132141007294 4 P16930,Q92947 2 +Regulation of respiratory gaseous exchange by nervous system process 0.4353325173398598 0.3376185770528682 0.7356506409418806 1.0 0.9132522687520244 2 P51608 1 +Amino acid homeostasis 0.4353325173398588 0.3376185770528647 0.7356506409418833 1.0 0.9132522687520244 2 P29144 1 +Regulation of centrosome cycle 0.382522063239027 0.3361238361458722 0.7367774844240771 1.0 0.9137430781059616 11 P38398 1 +Negative regulation of helicase activity 0.4848979591836683 0.3350739029881073 0.7375693384687665 1.0 0.9140930790966576 3 P33993,P04637 2 +Protein localization to cell junction 0.3558829534144934 0.3308839557377249 0.7407321414623769 1.0 0.916588836058597 19 Q13177,Q9UDY2,Q9UQB8,Q9Y624,Q15334 5 +Focal adhesion assembly 0.3618678853706531 0.329857267889064 0.7415078132344353 1.0 0.9170811854660162 17 O75122,Q14247,Q7Z460,Q9H2G2,P60903,O75116,Q96AC1,P63167 8 +Regulation of voltage gated calcium channel activity 0.4787624359442142 0.3286200350665463 0.7424429026121058 1.0 0.9179158536913122 4 Q06787 1 +Positive regulation of cell activation 0.3415227474297792 0.3276512271333071 0.7431753844143225 1.0 0.9184525977195872 34 Q92692,P11279,P02786 3 +Rig i signaling pathway 0.3826180229945251 0.3261650048268015 0.744299516931902 1.0 0.9191039161150664 10 O75179,Q07021 2 +Cell projection assembly 0.3178991866286045 0.3258267473114805 0.7445554406624479 1.0 0.9192331366616592 78 P61421,Q4KMP7,Q9BZH6,Q9H4M9,P11233,O94813,O95721,Q06787,Q9NQW6,Q14203,P42345,Q9Y5K6,P84095,O15439,Q15555,P51114,A6NIH7,P05556 18 +Positive regulation of deoxyribonuclease activity 0.4304365565075452 0.322641691447425 0.7469666156688204 1.0 0.9199000450015332 2 P23396 1 +Peroxisome organization 0.4765351360301714 0.3225617738770707 0.7470271474442616 1.0 0.9199000450015332 4 P28288 1 +Membrane raft assembly 0.4669069491240055 0.321882569266554 0.7475416587294597 1.0 0.9203384781129088 6 Q9UNF0,Q14254,O75955 3 +Cellular response to x ray 0.4667546409682612 0.32146672672702 0.7478567234340678 1.0 0.9203384781129088 6 Q9H1E3 1 +Extracellular vesicle biogenesis 0.4666383286348616 0.321149317336789 0.748097238231054 1.0 0.9203384781129088 6 Q8WUM4,Q9Y3E7,P51149,Q99816 4 +Regulation of protein targeting 0.3486702031738761 0.3205920974065507 0.7485195271155065 1.0 0.9203384781129088 21 Q9Y4C2,P31751,O43464,Q7Z6Z7,P55786 5 +Positive regulation of sprouting angiogenesis 0.4296205630354942 0.320179795428309 0.7488320385632965 1.0 0.9203384781129088 2 Q07157 1 +Regulation of sprouting angiogenesis 0.4296205630354942 0.320179795428309 0.7488320385632965 1.0 0.9203384781129088 2 Q07157 1 +Dendrite morphogenesis 0.346845858075739 0.3200974065756674 0.7488944915730151 1.0 0.9203384781129088 22 Q9UQB8,Q96HC4,Q9NUL3,Q15334,O60828,P05556 6 +Regulation of protein polymerization 0.3286823479348876 0.3194899842619174 0.7493549851548322 1.0 0.9205464173180968 52 Q9NYL9,Q13045,O94813,Q9UQB8,Q14203,Q14019,Q16625,P58546,O15143,P42345,O00165,Q15691,Q9NUQ9,P62993 14 +Response to lithium ion 0.4288045695634432 0.3177277953605278 0.7506914252708783 1.0 0.921820324170881 2 Q13144 1 +Regulation of amyloid precursor protein catabolic process 0.3800877858376195 0.3174082976494259 0.7509338118827802 1.0 0.9219340936714412 10 Q14254,P49755,Q96P70,O75116,P27695 5 +Cell cell signaling by wnt 0.3297386956977052 0.3171866693447295 0.7511019644111534 1.0 0.9219566975437544 47 P05067 1 +Microtubule bundle formation 0.3739117041565319 0.3133147190399223 0.7540415685319839 1.0 0.9244591671548038 12 Q15691,Q7Z460,O43663,A0AVF1,Q15555,Q66K74 6 +Dna dependent dna replication maintenance of fidelity 0.3736575925739792 0.3123805542664111 0.7547513269333621 1.0 0.9251451164500718 12 Q9H1E3,P54132,Q9UNS1 3 +Regulation of rig i signaling pathway 0.462826151320257 0.3108208674621471 0.7559368049572603 1.0 0.9254667265590076 6 O75179,Q07021 2 +Transcription preinitiation complex assembly 0.3781238752558969 0.3106683015223744 0.7560527973306876 1.0 0.9254667265590076 10 Q9UIF9,O15160 2 +Glomerular epithelial cell differentiation 0.4235006119951005 0.3020337832680469 0.7626263095367709 1.0 0.929800037191663 2 P80723 1 +Positive regulation of ion transmembrane transport 0.3493048361175163 0.3002028708418247 0.7640224153976776 1.0 0.93039675862411 19 Q9Y4C2,P30626,P05026,P54709,P08183,P05556 6 +Positive regulation of intracellular protein transport 0.3271234088194164 0.2992911916706658 0.7647178747853296 1.0 0.9310595125673868 42 Q9Y4C2,Q9C0E2,P31751,Q9Y282,O43464,P50402,P55786,Q92688,Q7Z6Z7 9 +Regulation of protein containing complex assembly 0.3140595606515841 0.2985764980809474 0.7652631997111423 1.0 0.9315392488377824 87 Q04637,Q9NYL9,P09429,Q13045,O94813,Q9UQB8,Q14203,Q15691,P02786,P58546,O15143,P42345,O00165,P04062,Q14019,Q96AC1,Q9NUQ9,O00571 18 +Hindbrain development 0.3391155690092134 0.2972926552425817 0.7662430885696239 1.0 0.931810921651822 31 P04062,P54802,Q92542,Q9BRK5 4 +Synaptic vesicle recycling via endosome 0.4697959183673413 0.2948251309284747 0.768127467577495 1.0 0.9332264817148104 3 O14617,Q4V328 2 +Synaptic vesicle endosomal processing 0.4697959183673413 0.2948251309284747 0.768127467577495 1.0 0.9332264817148104 3 O14617,Q4V328 2 +Positive regulation of nucleocytoplasmic transport 0.3397717636916426 0.2941387273344899 0.7686518989681774 1.0 0.9334496532439978 23 Q9C0E2,Q16630,O00410,Q9BVS4,P50402,Q92688,P62826 7 +Modulation by host of viral genome replication 0.4286204735190515 0.2936922646056835 0.768993065732644 1.0 0.933679807871404 7 Q06787 1 +Regulation of glial cell differentiation 0.4014525214014149 0.2932658386026616 0.7693189631031017 1.0 0.9337072453825738 8 Q13547,P42345 2 +Negative regulation of receptor internalization 0.4685975123948637 0.2917436619192065 0.7704826233047188 1.0 0.9345483724592122 3 Q15334 1 +Rac protein signal transduction 0.3746611282621315 0.2915651207214536 0.7706191468207602 1.0 0.9345483724592122 9 P84095 1 +Positive regulation of hormone secretion 0.4005640938549264 0.2906001868358757 0.7713571171672009 1.0 0.93470690226303 8 P30626,P51809 2 +Response to mechanical stimulus 0.3650793252430771 0.2902819148786187 0.771600573323556 1.0 0.9348179319073464 13 Q9Y624 1 +Dendritic spine morphogenesis 0.360792829813961 0.2850938151054046 0.7755722683510156 1.0 0.937331983478502 14 Q9NUL3,Q9UQB8,Q15334,Q96HC4 4 +Enteroendocrine cell differentiation 0.4618211514904033 0.283902805492206 0.77648486645383 1.0 0.9379669065639064 4 P49840,Q00534,O00330 3 +Pallium development 0.336004730695119 0.2825257953732086 0.777540370026383 1.0 0.938689423186753 32 Q13547,O94813,O14949 3 +Regulation of mitochondrial fission 0.4511888333117104 0.2802139364855839 0.779313375041595 1.0 0.9400995496584832 6 P11233,Q96HS1,Q9NUQ9 3 +Acidic amino acid transport 0.3711027525904837 0.2802063887551768 0.7793191654144709 1.0 0.9400995496584832 9 P05556 1 +Very long chain fatty acid catabolic process 0.463481710259325 0.2787810923148307 0.7804128255726499 1.0 0.940740880947382 3 P28288 1 +Regulation of receptor internalization 0.3706321105930161 0.2787170439437401 0.7804619814648737 1.0 0.940740880947382 9 P30533,Q15334,O75955,Q06787 4 +Muscle contraction 0.3344846218736825 0.2780974982755205 0.7809375161122707 1.0 0.9411298271096596 33 Q9NYL9,P05026,Q14126,P42345,P10253,P20020 6 +Regulation of er to golgi vesicle mediated transport 0.4511442239865899 0.2763506618439348 0.7822787477618642 1.0 0.9423772745000584 5 Q6NUQ1 1 +Type b pancreatic cell development 0.4616326530612203 0.2741731756233703 0.7839515412970146 1.0 0.9427532840037486 3 P49840,Q00534 2 +Glycosyl compound biosynthetic process 0.4488166116655921 0.2741505237884615 0.7839689482051637 1.0 0.9427532840037486 6 Q13126 1 +Nucleobase containing small molecule biosynthetic process 0.4488166116655921 0.2741505237884615 0.7839689482051637 1.0 0.9427532840037486 6 Q13126 1 +Intra golgi vesicle mediated transport 0.3669559531594775 0.2733222785936848 0.7846054912555034 1.0 0.9430905429973744 10 Q99747,Q9Y678 2 +Binding of sperm to zona pellucida 0.364455364455363 0.2725304772049801 0.785214160378354 1.0 0.9430905429973744 11 P50990,P17987,O14967,Q14157,P04075,P78371,P45880,P49368,Q99832,P50991 10 +Sperm egg recognition 0.364455364455363 0.2725304772049801 0.785214160378354 1.0 0.9430905429973744 11 P50990,P17987,O14967,Q14157,P04075,P78371,P45880,P49368,Q99832,P50991 10 +Positive regulation of organ growth 0.4570457893258506 0.2718824516598362 0.7857124047030775 1.0 0.9430905429973744 4 O00763 1 +Positive regulation of heart growth 0.4570457893258506 0.2718824516598362 0.7857124047030775 1.0 0.9430905429973744 4 O00763 1 +Cochlea development 0.44934640522876 0.2717930608683311 0.7857811410713873 1.0 0.9430905429973744 5 P49736,Q9BW83,P43034,P33993 4 +Regulation of protein localization to centrosome 0.4599999999999956 0.2701390372921662 0.7870532907023267 1.0 0.9440652855745616 3 P49841,Q9UNZ2 2 +Action potential 0.3454986414138327 0.2698359438414506 0.787286468955799 1.0 0.9441610419479656 18 Q14126,P04062,P05026,Q06787 4 +Regulation of reactive oxygen species biosynthetic process 0.3677113960350627 0.2695433950092213 0.7875115530277843 1.0 0.9442470558893996 9 P51790 1 +Regulation of cell morphogenesis involved in differentiation 0.334698303915479 0.2682314248261029 0.788521187468243 1.0 0.9450895369363388 23 Q9UQB8 1 +Tube morphogenesis 0.3106279235066079 0.2672818504233918 0.7892521598598448 1.0 0.9452674116011852 73 P55011,P11233,O94813,P67870,P42785,Q15375,Q9UNS1,Q96PU8,P35613,P05556 10 +Microtubule organizing center organization 0.3344269310615014 0.2672338268929982 0.7892891328029765 1.0 0.9452674116011852 28 Q9UHD1,P52732,O75122,Q15154,Q14203,Q9UNZ2,Q7Z460,Q9Y3E7,P43487,O75116,O94927,P38398 12 +Histone h4 k20 methylation 0.4551653199256166 0.2672219776510989 0.7892982555152863 1.0 0.9452674116011852 4 P38398 1 +Regulation of rna polymerase ii transcription preinitiation complex assembly 0.4548795426704642 0.2665173625863296 0.7898407894109798 1.0 0.9452674116011852 4 P09429,P62333,P04637 3 +Rna polymerase ii preinitiation complex assembly 0.4548795426704642 0.2665173625863296 0.7898407894109798 1.0 0.9452674116011852 4 P09429,P62333,P04637 3 +Muscle system process 0.3224410035937206 0.2651438010028765 0.7908986861067473 1.0 0.9455349627425232 48 Q9NYL9,P05026,Q12802,Q14126,Q96HC4,P58546,P42345,P10253,P50402,P20020 10 +Spindle elongation 0.4462353053346328 0.2639934836613697 0.7917849399773706 1.0 0.9455349627425232 5 Q02241,O43663 2 +Interferon beta production 0.3652765586802462 0.2619877412534596 0.7933308932587606 1.0 0.9469829991846044 9 O75955,P26583,O00571 3 +Positive regulation of interferon beta production 0.3652765586802462 0.2619877412534596 0.7933308932587606 1.0 0.9469829991846044 9 O75955,P26583,O00571 3 +Regulation of oligodendrocyte differentiation 0.4433458245855919 0.2604010850939751 0.7945544060350536 1.0 0.9470560972049984 6 Q13547,P42345 2 +Positive regulation of signaling receptor activity 0.4443897412869493 0.259419410751534 0.7953116546099341 1.0 0.9473065644898124 5 Q13547,P05556 2 +Regulation of cell size 0.3293196241521755 0.2593484339934007 0.795366412480379 1.0 0.9473065644898124 35 P55011,P42345,P58546,Q15375,P51790 5 +Regulation of lipid localization 0.3508692407585949 0.2592423459272527 0.795448260258621 1.0 0.9473065644898124 15 Q8WTV0,P31751,Q9H4M9 3 +Regulation of phosphorus metabolic process 0.3215018202928048 0.2589984903563696 0.7956364052839788 1.0 0.9473473887707324 172 P05067,Q14738,Q13177,P61981,Q8IXB1,P02786,O00410,P31751,P54132,Q13610,Q96AC1,O95373,Q13546,Q05639,Q15185,Q8WTV0,Q06787,O94813,Q13217,Q15375,Q13501,Q96A49,Q12802,P04062,P51114,Q15334,Q9C0C2,P67870,Q8WUA2,P42345,A4D1P6,O00165,Q9H7B4,Q9P287 34 +Maintenance of dna methylation 0.4516129032258115 0.2585318758486317 0.7959964514925852 1.0 0.947355970648606 4 P26358,Q96T88,Q9NRZ9 3 +Positive regulation of actin filament polymerization 0.3641437174646279 0.2585012497976389 0.7960200844969976 1.0 0.947355970648606 9 Q9UQB8,P62993,P42345 3 +Ruffle organization 0.3562927635248901 0.2581915503020698 0.7962590787894326 1.0 0.947355970648606 13 P84095,Q9UHB6 2 +Axonal transport of mitochondrion 0.4513068590332637 0.2577902448180187 0.7965687936075057 1.0 0.9475413566926996 4 Q9UH62 1 +Cellular response to hormone stimulus 0.304677719063665 0.2574416306122851 0.7968378689812146 1.0 0.9476676070829634 98 Q6ZWJ1,Q9BSK2,P31751,Q06481,Q13547,Q15185,O94813,O15118,Q9H1E3,Q96A49,Q9UQB8,P20020,P38398,P67870,P42785,Q9H7B4,O43865,Q13243,O95831 19 +Positive regulation of rna polymerase ii transcription preinitiation complex assembly 0.4546938775510165 0.2572539192891519 0.7969827626239376 1.0 0.9476676070829634 3 P62333,P04637 2 +Regulation of organic acid transport 0.3634209148319849 0.2562863841137958 0.7977297101502161 1.0 0.9480065287386374 9 P55011,P05556 2 +Regulation of protein k63 linked ubiquitination 0.4414363706908459 0.2556801127038971 0.7981978526228228 1.0 0.9481072024587476 6 Q9Y263 1 +Alditol catabolic process 0.4067727458180339 0.2554052246172463 0.7984101359165643 1.0 0.9481072024587476 2 P43304 1 +Germ cell development 0.331227701257985 0.2492378854577008 0.8031767755163814 1.0 0.9520907598872468 29 Q92692,P07686,P26583,P42345,A0AVF1,Q96PU8,Q01085,P17612,P62826 9 +Regulation of cell projection assembly 0.3199134878731095 0.2481442411998701 0.804022806288456 1.0 0.9523602189915398 43 Q4KMP7,Q06787,P11233,O94813,Q9NQW6,P42345,P84095,Q15555,P51114 9 +Tube development 0.3060473041511449 0.24651859841367 0.8052808091420998 1.0 0.953610295842297 94 P55011,Q15185,P11233,O94813,P67870,P42785,P42892,Q15375,Q9UNS1,Q96PU8,P38571,P35613,P05556 13 +Positive regulation of meiotic cell cycle 0.4497959183673412 0.2456707831961211 0.805937090784026 1.0 0.95401608028571 3 Q8IXJ6,Q9H6S0 2 +Positive regulation of myeloid leukocyte differentiation 0.4497377550617651 0.2455350465329002 0.8060421753020124 1.0 0.95401608028571 3 O00165 1 +Regulation of protein secretion 0.3300091033071338 0.2446793078148351 0.8067047510899257 1.0 0.95401608028571 27 P55011,Q6ZWJ1,P30626,Q16850,Q32P28,P49755,Q96KC8,Q9Y5K6,O00429,P17858,P35580,Q15334 12 +Platelet morphogenesis 0.4380782641453452 0.2440786015043897 0.8071699449599266 1.0 0.95401608028571 5 Q96AX1 1 +Regulation of endoplasmic reticulum tubular network organization 0.445487954267045 0.2439041101286433 0.8073050858781987 1.0 0.95401608028571 4 P57088,Q15041,Q15042 3 +Positive regulation of protein secretion 0.3497399108848066 0.2437039759538449 0.8074600938359122 1.0 0.95401608028571 14 P30626,P49755,Q9Y5K6,O00429,P35580 5 +Cellular response to oxygen levels 0.3302025462324512 0.2435841630382826 0.8075528949754975 1.0 0.95401608028571 29 P55786,O95831,Q15904 3 +Cardiac muscle cell membrane repolarization 0.4364056440070019 0.2434386411636872 0.8076656126414998 1.0 0.95401608028571 6 P05026 1 +T helper 1 type immune response 0.4485132652658468 0.2426873779093956 0.8082475861569538 1.0 0.95401608028571 3 P42345 1 +T helper 1 cell differentiation 0.4485132652658468 0.2426873779093956 0.8082475861569538 1.0 0.95401608028571 3 P42345 1 +Regulation of presynaptic cytosolic calcium ion concentration 0.4484022704937579 0.2424301886907839 0.8084468447285926 1.0 0.95401608028571 3 P20020 1 +Wound healing spreading of epidermal cells 0.4369291260008157 0.2413363249272088 0.8092944595309832 1.0 0.95401608028571 5 Q96AC1,P42345,Q7Z460 3 +Positive regulation of phospholipase activity 0.4352366685330419 0.2406353903184923 0.8098377185039038 1.0 0.9544737428844824 6 Q9Y263 1 +Selective autophagy 0.3319622167362602 0.2400159192727727 0.8103179154787294 1.0 0.954856919732543 21 Q13501,O15269 2 +Response to peptide hormone 0.3053781594705424 0.2387608555516054 0.8112910251686714 1.0 0.9552515489880546 68 Q6ZWJ1,Q96A49,Q9BSK2,Q9UQB8,Q99523,P20020,P42345,O43865,P31751,Q13243,Q9H1E3,P35613,Q06481,Q9NR50 14 +Nuclear transcribed mrna catabolic process exonucleolytic 0.352722312632704 0.2385835099603233 0.8114285530627783 1.0 0.9552515489880546 12 Q9ULM6,Q9NQT5,Q9Y2L1,Q15024,Q96C86 5 +Regulation of autophagy 0.3055011949835748 0.2356336896114346 0.8137169289146464 1.0 0.956437724229295 69 O75436,P10619,O15118,P04062,O43464,Q93050,O15269 7 +Fertilization 0.3282815244012146 0.2354825630953817 0.8138342110179106 1.0 0.956437724229295 27 P07686 1 +Spindle midzone assembly 0.441776057428594 0.2352616780848742 0.814005636879555 1.0 0.956456623333477 4 Q02241,O43663 2 +Cell cell adhesion mediated by cadherin 0.4342424994078242 0.2349869102601364 0.8142188928951115 1.0 0.9565246562784204 5 O75955 1 +Fear response 0.4448518842957716 0.2342863029874315 0.8147627186819777 1.0 0.9569435480270084 3 Q04637 1 +Skin development 0.3284472615544422 0.2339574044770563 0.8150180472827255 1.0 0.9569435480270084 29 Q15392,P04062,Q13510 3 +Regulation of protein localization to membrane 0.3269231718874931 0.2333205920561402 0.8155124696667122 1.0 0.9570968252629029 33 Q13501,Q14651,Q9Y4C2,O15258,O00264,P84095,P31751,Q15334,Q96CW1,P05556 10 +Cellular response to oxygen containing compound 0.314878962848739 0.2330509543195704 0.8157218390725351 1.0 0.9570968252629029 159 P05067,Q8WTV0,O94813,Q9UQB8,Q99538,Q9H7B4,O43464,P54132,Q92542,Q9UNS1,Q96C86,O95831,Q06481 13 +Regulation of mrna polyadenylation 0.3524886550177267 0.2329579247310021 0.8157940781191675 1.0 0.9570968252629029 11 Q16630 1 +Positive regulation of neurogenesis 0.3258639251700234 0.2320116851139573 0.8165289380066434 1.0 0.9574116685025524 34 P55209,O94813,Q9UQB8,Q13573 4 +Positive regulation of nervous system development 0.3258639251700234 0.2320116851139573 0.8165289380066434 1.0 0.9574116685025524 34 P55209,O94813,Q9UQB8,Q13573 4 +Positive regulation of rna binding 0.4328267721934018 0.2316761614619276 0.8167895480731964 1.0 0.957534890991369 5 Q06787 1 +Negative regulation of response to wounding 0.4324533734622112 0.2308070080511346 0.8174647365853507 1.0 0.9577710053316676 5 Q96G23 1 +Circadian rhythm 0.3164579652095001 0.230209128421047 0.8179292688861539 1.0 0.957776817902634 40 Q13547,Q9Y2K7,P54802,Q03164,Q9UNS1,Q7Z6Z7,Q9Y2W1 7 +Regulation of protein polyubiquitination 0.3792199638335164 0.2296218187371027 0.8183856509520742 1.0 0.9581290079695608 8 Q9Y263 1 +Ventricular cardiac muscle tissue development 0.4389117171807668 0.2287089771314871 0.8190951169719334 1.0 0.9585950646637892 4 Q14126 1 +Positive regulation of stress fiber assembly 0.3782295924858487 0.2269413630188783 0.820469338003601 1.0 0.959291628197526 8 Q96AC1,P60903,P42345 3 +Endothelial cell development 0.3419745733110073 0.2255257305774326 0.8215703107958767 1.0 0.9601236002913996 15 Q9Y624,O60568 2 +Viral translational termination reinitiation 0.4286881896199503 0.2252244453486317 0.8218046733044788 1.0 0.9601236002913996 6 O15371,Q9Y262,O75821,P56537,Q14152 5 +Animal organ morphogenesis 0.3046312826522106 0.2242294165705377 0.8225787950621604 1.0 0.960663437252982 70 O94813,P10253,P04062,P54802,Q92896 5 +Positive regulation of protein autophosphorylation 0.4363818708421823 0.2230065847977687 0.8235303816236839 1.0 0.9615923686055416 4 Q9C0C2 1 +B cell activation 0.3261050713063362 0.2212195990187689 0.8249214494689152 1.0 0.9626689470015374 29 P02786 1 +Aspartate family amino acid biosynthetic process 0.3468477868131217 0.2190799518984764 0.8265877675031179 1.0 0.9633317055743564 12 Q13126,Q9NRN7,Q9BV20 3 +Mrna 5 splice site recognition 0.4345723008825921 0.2189770388329526 0.8266679340666074 1.0 0.9633317055743564 4 Q07955 1 +Pyrimidine ribonucleotide metabolic process 0.3990871113210886 0.2159747739914462 0.8290074109625218 1.0 0.9645122126410142 7 P15531,Q9NRF8 2 +Pyrimidine ribonucleotide biosynthetic process 0.3990871113210886 0.2159747739914462 0.8290074109625218 1.0 0.9645122126410142 7 P15531,Q9NRF8 2 +Positive regulation of phospholipid biosynthetic process 0.435914358631623 0.2145048101646942 0.8301534162937148 1.0 0.9651887397426104 3 P17655 1 +Glandular epithelial cell differentiation 0.4252450980392177 0.2143637387279419 0.8302634166960354 1.0 0.9651887397426104 5 P49840,Q00534,O00330,P49841 4 +Vesicle mediated transport in synapse 0.3246203328492993 0.2142235827286131 0.8303727065805762 1.0 0.9651887397426104 28 Q06787,O95721,Q4J6C6,P51790,O14617,Q9Y263 6 +Regulation of respiratory gaseous exchange 0.435510204081627 0.2136348990828953 0.8308317820917239 1.0 0.9653578566406388 3 Q9C0B1,P51608 2 +Regulation of respiratory system process 0.435510204081627 0.2136348990828953 0.8308317820917239 1.0 0.9653578566406388 3 Q9C0B1,P51608 2 +Mesoderm development 0.3487317771938962 0.2129610891840878 0.8313573128047924 1.0 0.9654312120733276 9 Q16881,P17612,P05556 3 +Telencephalon development 0.3226296354542968 0.2129508211702375 0.8313653218146473 1.0 0.9654312120733276 34 Q13547,O94813,O14949 3 +Cerebellar cortex morphogenesis 0.4231792016577938 0.212650606575732 0.8315994957390187 1.0 0.9655210437988192 6 P04062 1 +Regulation of dendritic spine development 0.3453926346699652 0.2105392398003117 0.8332468289799586 1.0 0.9665165879662914 11 Q9NUL3,Q14444,Q9UQB8,Q06787 4 +Negative regulation of stress activated protein kinase signaling cascade 0.3477456809537521 0.2101713064574187 0.8335339735334946 1.0 0.9665165879662914 9 Q96J02,P31689,P78318,Q96KB5 4 +Regulation of response to wounding 0.3415720307583303 0.2071693709819905 0.8358775868065595 1.0 0.9677501400683202 13 P55011,Q96G23,P42345,Q96AC1,P05556 5 +Membrane depolarization during action potential 0.3871889024887792 0.2066462664526343 0.8362861246388587 1.0 0.9677501400683202 2 Q12955 1 +Leukotriene metabolic process 0.4277829343622883 0.2042288161727475 0.8381746938360026 1.0 0.9685238557888496 4 O14880 1 +Neuron projection extension 0.3226323337435656 0.202567611283893 0.8394730075718382 1.0 0.9691796939095833 29 O94813,Q9Y263 2 +Fatty acid transport 0.3412313739823456 0.2009652850825065 0.8407257187488746 1.0 0.969414005894978 12 O43772,P31751,O43808 3 +Heterotypic cell cell adhesion 0.3927542783068536 0.2007435787549261 0.8408990823364495 1.0 0.969414005894978 7 Q14126,O75955,P05556 3 +Optic nerve development 0.3843329253365958 0.2000812600062118 0.8414170293748038 1.0 0.9696872313145124 2 P83731 1 +Regulation of protein dephosphorylation 0.3230910983080461 0.1994239393968985 0.8419311356313073 1.0 0.9698353605391878 21 P67870,Q14738,P04062 3 +Lymphocyte activation 0.3034638071299994 0.1989237178560755 0.8423224160992955 1.0 0.9701045858442504 75 Q92542,Q9UQ84,P11279,P02786 4 +Glandular epithelial cell development 0.4250714577378552 0.1985037610898833 0.8426509423788966 1.0 0.9703014498273548 4 P49840,P49841,Q00534 3 +Lateral ventricle development 0.3835169318645436 0.1982314737787795 0.8428639635569399 1.0 0.970365262457008 2 Q00534 1 +Negative regulation of jnk cascade 0.4177852346719791 0.1980283305718755 0.8430228980461374 1.0 0.9703667944045744 5 Q96J02,P31689 2 +Pyrimidine nucleobase biosynthetic process 0.3908625572143572 0.196297087645649 0.8443776407710706 1.0 0.9710487681503182 7 Q9NRF8,P42345 2 +Regulation of aspartic type endopeptidase activity involved in amyloid precursor protein catabolic process 0.4271503646423024 0.1961248838381412 0.8445124199831353 1.0 0.9710487681503182 3 P49755 1 +Regulation of aspartic type peptidase activity 0.4271503646423024 0.1961248838381412 0.8445124199831353 1.0 0.9710487681503182 3 P49755 1 +Positive regulation of protein modification process 0.3004429532111256 0.1957918944900945 0.8447730545500307 1.0 0.9710487681503182 134 P05067,Q14738,Q13177,P02786,P31751,Q15020,Q13573,Q96AC1,Q13546,Q06787,Q15375,Q16763,Q13501,Q96A49,Q12802,P04062,Q03164,P51114,Q15334,P38398,Q9C0C2,P67870,P42345,O00165,Q9H7B4,Q7Z6Z7 26 +Hormone mediated signaling pathway 0.3209088995019925 0.1956589821863824 0.8448770912751753 1.0 0.9710487681503182 32 Q15185,P67870,P42785,Q06481,P38398 5 +Histone h3 k9 modification 0.3657191972646532 0.1942853849005756 0.8459524287583831 1.0 0.9716918813485282 8 Q03164 1 +Muscle hypertrophy 0.3289833137092831 0.19347576799646 0.8465863818476536 1.0 0.971852365091603 17 Q13177,Q92769,Q12802,Q96HC4,P58546,O75116 6 +Regulation of cell cycle g2 m phase transition 0.3207273870144085 0.19245883247707 0.8473828119803959 1.0 0.9722951869853332 29 P05067,P54132,P38398 3 +Regulation of cell activation 0.312037047000435 0.1922016252338725 0.8475842728848364 1.0 0.9723451403301544 49 Q9Y624,P11279,P02786 3 +Viral gene expression 0.3200461631387169 0.1908591279065606 0.848635962669162 1.0 0.9733702723833886 32 Q13547,Q10472,Q9ULC4,Q13573,Q9H1E3,Q99873 6 +Cortical actin cytoskeleton organization 0.3346559860660892 0.1905136810748357 0.8489066235658427 1.0 0.9734993632510512 14 Q14651,Q9NQW6,Q15334 3 +Negative regulation of i kappab kinase nf kappab signaling 0.420263395010172 0.1885859491350272 0.8504173461713127 1.0 0.974554761985637 4 Q13547 1 +Extracellular matrix disassembly 0.410623471099922 0.1853641490679911 0.8529434259990816 1.0 0.9750413430888126 6 O75955,Q7Z460 2 +Regulation of smooth muscle contraction 0.4205360276051961 0.1829312823598629 0.8548519372642454 1.0 0.9757914884295178 3 P20020 1 +Er overload response 0.4101307189542503 0.1820022901295181 0.8555809286561629 1.0 0.9757914884295178 5 Q9UM00,P49841,O76024,P04637 4 +Dna templated transcription termination 0.3605811588274565 0.1815368789536597 0.8559461887960427 1.0 0.9757914884295178 8 Q9UPN6,O75844 2 +Positive regulation of actin filament bundle assembly 0.3364704908874513 0.1793830597135083 0.8576369320324029 1.0 0.9757914884295178 9 Q96AC1,P60903,P42345 3 +Secretion 0.2897751629729884 0.1779671420090635 0.8587487806439957 1.0 0.9757914884295178 107 Q6ZWJ1,O43760,P50897,O15439,Q658P3,P11279,Q06787,Q7Z392,P49755,Q9Y5K6,P55011,P15531,Q96KC8,P51809,Q4J6C6,Q9BRK5,Q15334,P35579,P30626,P11233,O95721,Q9Y678,Q9Y3E7,P17858 24 +Cellular ketone metabolic process 0.3164681037276989 0.1778607978486238 0.8588322986782644 1.0 0.9757914884295178 26 O00763,Q6YP21,Q14849,P31751,Q06481,P38398 6 +Regulation of intracellular signal transduction 0.321772319489337 0.1777785627213864 0.8588968836195878 1.0 0.9757914884295178 199 P05067,Q9NUD5,P02786,Q9UMX5,P13693,O94813,Q15375,O43657,O00170,P05556,Q13501,Q12802,Q9Y624,P04062,O75179,Q07021,P49427,O43464,Q99873 19 +Regulation of histone h3 k4 methylation 0.3341601109526474 0.1767483457176049 0.8597060642600685 1.0 0.9760667965423642 11 Q03164,P38398 2 +Regulation of protein export from nucleus 0.3300533611259301 0.1750993800766966 0.8610015453728763 1.0 0.9771772377623592 14 Q9C0E2,Q92688 2 +Negative regulation of cellular component organization 0.298084042868054 0.1741749511783583 0.8617279706922614 1.0 0.977688840871164 133 P05067,Q9NYL9,O94813,Q96G23,Q9UHB6,P02786,Q9Y624,Q15375,P04062,Q15334,P38398 11 +Positive regulation of stem cell proliferation 0.4149540138216189 0.1722554859932279 0.8632366782168224 1.0 0.9779632326144536 3 Q96AC1 1 +Regulation of wound healing 0.3332817602607651 0.171958781411551 0.8634699338943435 1.0 0.9779632326144536 10 P55011,Q96AC1,P05556,P42345 4 +Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 0.3712770297837647 0.1718775371309434 0.8635338065372737 1.0 0.9779632326144536 2 P42765 1 +Insulin secretion involved in cellular response to glucose stimulus 0.4039681649430624 0.1696501508135201 0.8652852795309569 1.0 0.9791171294390602 5 Q6ZWJ1,P30626 2 +Regulation of insulin secretion involved in cellular response to glucose stimulus 0.4039681649430624 0.1696501508135201 0.8652852795309569 1.0 0.9791171294390602 5 Q6ZWJ1,P30626 2 +Nuclear migration 0.3323529577096116 0.1694244832250117 0.8654627670450972 1.0 0.9791171294390602 10 Q5SNT2 1 +Positive regulation of dendritic spine development 0.3322022848888426 0.1690147632363942 0.8657850290749418 1.0 0.9791171294390602 10 Q9NUL3,Q9UQB8,Q06787 3 +Benzene containing compound metabolic process 0.4102519024117131 0.1689055947825716 0.8658708984299155 1.0 0.9791171294390602 4 Q6YP21 1 +Protein localization to cell cell junction 0.3552677209767089 0.1687713382334617 0.8659765036653351 1.0 0.9791171294390602 8 Q9Y624,Q9UDY2 2 +Signal release 0.3102915752796112 0.1678287300355718 0.866718019763931 1.0 0.9791171294390602 38 O95721,P51809,P17858,P50897,O15439 5 +Gamete generation 0.3006557799477715 0.1663669163695264 0.8678682080101507 1.0 0.9795535392701188 80 Q96EP5,Q9BW83,Q13162,P25440,P07686,Q92692,P42345,P26583,Q8NB78,Q9Y508,Q9UGV2,P20042,Q96PU8,P11717,P05556,Q9H8Y8,O00571 17 +Regulation of membrane permeability 0.3200877702664875 0.165523935235015 0.8685316120759015 1.0 0.979943033819191 18 Q9Y624,Q9UDY2 2 +Protein deneddylation 0.3525562372188063 0.1624232420927681 0.8709725693050763 1.0 0.9810790540086636 8 Q9UNS2,Q9UBW8,Q9BT78,P61201,Q92905,Q99627,Q13098 7 +V d j recombination 0.406047619295663 0.1610357376772301 0.8720652533590909 1.0 0.9817710303404504 4 P26583 1 +Positive regulation of transmembrane transport 0.313311198688068 0.1597951436747106 0.8730424497110918 1.0 0.9821332765575918 22 Q9Y4C2,P30626,P05026,Q16625,P54709,P31751,P08183,P05556 8 +Rna polyadenylation 0.3144740745838492 0.1590412135051007 0.8736364033675632 1.0 0.9821332765575918 30 P05067,Q16630 2 +Regulation of protein localization to chromatin 0.3647490820073411 0.158895875832009 0.8737509100247138 1.0 0.9821332765575918 2 Q7Z5K2 1 +Protein localization to microtubule 0.396360416529584 0.1567481488675124 0.8754433387675915 1.0 0.9821332765575918 6 Q15555 1 +Collagen biosynthetic process 0.4036627744110364 0.1566760905902429 0.8755001312804436 1.0 0.9821332765575918 4 Q92791 1 +Protein polymerization 0.2987377106887418 0.1564011443309166 0.8757168352296854 1.0 0.9821332765575918 65 Q9NYL9,Q13045,O94813,Q96P70,Q9UQB8,Q14203,Q9Y3E7,Q14019,P58546,O00429,O15143,Q16625,P42345,O00165,Q15691,Q9NUQ9,Q16763,P62993 18 +Lamellipodium assembly 0.3190341541902849 0.1562092144338966 0.8758681138307489 1.0 0.9821332765575918 17 O94813 1 +Carbohydrate derivative biosynthetic process 0.2897856802188074 0.1559935355517134 0.8760381167265079 1.0 0.9821332765575918 121 P06865,Q13126,Q10472,O15118,Q10471,P50897,Q92542,O43505,Q8NCH0 9 +Positive regulation of release of cytochrome c from mitochondria 0.3962418300653614 0.1548660971386344 0.8769268817002835 1.0 0.982573031961537 5 O00429,Q96A26,O14737,P04637 4 +Microtubule based movement 0.3000603758265546 0.1526130667832662 0.878703419912336 1.0 0.984129578403395 63 P05067,Q00577,P11279,Q5SNT2,Q9BW83,Q9UH62,Q14203,Q66K74,Q9BW19 9 +Granulocyte differentiation 0.3938068972694281 0.1518980244666276 0.8792673664614945 1.0 0.984129578403395 6 Q14739 1 +Positive regulation of rna splicing 0.3121867218610994 0.1506465944936448 0.8802545037066662 1.0 0.9845920352875898 20 Q96EP5,P26368,Q13573,Q9Y2W1 4 +Import into nucleus 0.3053385858962914 0.1505246478015741 0.8803507061380011 1.0 0.9845920352875898 53 Q8TEX9,Q13501,Q9UI26,O95373,Q06481 5 +Regulation of protein folding 0.4016326530612182 0.1484876718750171 0.8819579145227661 1.0 0.9860568149113258 3 Q9H2J4,P08621 2 +Pyrimidine nucleotide metabolic process 0.322950959338794 0.1480537986098466 0.8823003108815912 1.0 0.9860815055541762 13 P15531,P23919,Q9NRF8,P33316 4 +Cellular response to starvation 0.3135363688599328 0.1472472605965563 0.8829368585530921 1.0 0.9866138363178564 19 P04062 1 +Leukocyte cell cell adhesion 0.3120067533227186 0.1462725968698858 0.8837061976926908 1.0 0.9867074752698528 30 P02786 1 +Heart growth 0.3230812320068607 0.146199351500455 0.8837640174880321 1.0 0.9867074752698528 12 Q96HC4,Q12802 2 +Asparagine metabolic process 0.3578131374948959 0.1459229619753936 0.8839822045782861 1.0 0.9867074752698528 2 P08243 1 +Cellular response to peptide hormone stimulus 0.3051003292846335 0.144559815832874 0.8850584262005996 1.0 0.9870854051756534 48 Q6ZWJ1,Q96A49,Q9BSK2,Q9UQB8,P20020,O43865,P31751,Q13243,Q9H1E3,Q06481 10 +Positive regulation of protein tyrosine kinase activity 0.3967666745693498 0.1444964650877403 0.8851084476111295 1.0 0.9870854051756534 4 Q15334 1 +Long chain fatty acid transport 0.3228663706204246 0.1444014183268844 0.8851834968854417 1.0 0.9870854051756534 10 O43772,P31751 2 +Positive regulation of myeloid cell differentiation 0.3224186973659082 0.1443141176875322 0.8852524307010983 1.0 0.9870854051756534 12 O00165,Q99873,P26583 3 +Regulation of striated muscle cell differentiation 0.3438872208520233 0.1428934502904111 0.8863743314013979 1.0 0.9879447426572062 8 Q13547 1 +Regulation of protein localization to plasma membrane 0.3093459913745144 0.1424699689330836 0.8867087986949123 1.0 0.9879598395882327 22 Q13501,Q14651,O15258,O00264,P84095,Q96CW1,P05556 7 +Negative regulation of actin filament depolymerization 0.3178914050703125 0.14153449566337 0.8874477107190473 1.0 0.988246618718968 15 Q9NYL9,Q9UHB6,P58546 3 +Protein catabolic process 0.3214477001871436 0.1411726948655414 0.8877335163594204 1.0 0.9883861230063204 218 Q9UIQ6,O75503,Q8IXB1,Q99538,P50897,Q9Y263,P60900,P10619,O14773,Q16763,Q13501,P49721,Q9UHG3,O43847,P04062,P28072,Q9UG56,Q9Y3E7,P49427,Q93034,O43464 21 +Positive regulation of protein acetylation 0.3883821546453487 0.1406365456631089 0.8881570758867827 1.0 0.9885995263722128 5 P38398 1 +Cellular response to radiation 0.3091501896089874 0.1405235865732459 0.8882463179943285 1.0 0.9885995263722128 35 Q9C0C2,O75844,Q06787,Q9NXR7,P31751,P54132,Q9H1E3,P38398 8 +Positive regulation of cell cycle 0.2959790042296857 0.14007067352891 0.8886041512632248 1.0 0.988625123542528 73 P05067,Q99538 2 +Negative regulation of protein containing complex assembly 0.3102236419904041 0.1394229846527667 0.8891159106125734 1.0 0.9887394469757812 33 Q9NYL9,P09429,Q13045,O94813,P58546,Q9NUQ9,P04062,O00571 8 +Positive regulation of interferon gamma production 0.3928590909122915 0.1378771370964373 0.8903375197687091 1.0 0.9894960485949352 4 Q9NUQ9 1 +Regulation of dendritic spine morphogenesis 0.3171836547760415 0.1298755242850895 0.8966649090435681 1.0 0.9938372358202068 11 Q9NUL3,Q9UQB8,Q96HC4 3 +Rhythmic process 0.3024812452759578 0.1291117757460314 0.8972692043028676 1.0 0.9943280221189266 52 Q13547,O94813,Q9Y2K7,P54802,Q03164,Q9UNS1,Q7Z6Z7 7 +Regulation of myelination 0.3585707234301447 0.1280232194533364 0.8981305977740308 1.0 0.9949244495312536 7 Q96P11 1 +Regulation of dna templated transcription initiation 0.3150224268850636 0.126720509918184 0.8991616121359871 1.0 0.9958873980790202 9 P53999 1 +Post translational protein modification 0.315631415068289 0.1263958478966357 0.8994185886933468 1.0 0.9959928508246289 10 Q32P28,Q8TBC4 2 +Calcium ion export 0.383483345542186 0.1228271547097681 0.902243970721038 1.0 0.9975730574708056 4 P20020 1 +Post chaperonin tubulin folding pathway 0.3853648784009319 0.1227374008660428 0.9023150461545324 1.0 0.9975730574708056 3 O75347 1 +Response to tumor necrosis factor 0.3024599420906219 0.121627011439641 0.9031944202668076 1.0 0.9978410273789224 24 P38398,P04062,Q13510 3 +Nucleoside diphosphate biosynthetic process 0.3540304591837587 0.1196118570435544 0.9047906266005868 1.0 0.9990666944009708 7 P23919 1 +Positive regulation of collagen metabolic process 0.3419012647898801 0.1193302834402169 0.9050136921914242 1.0 0.9991338179707008 2 Q92769 1 +Rrna 3 end processing 0.3809153529789527 0.1189095104714059 0.9053470469576425 1.0 0.9993226547361428 4 Q15024 1 +Protein k29 linked ubiquitination 0.3823922633505126 0.1184187851037198 0.9057358421418344 1.0 0.9994820967119586 3 Q16763 1 +Protein k11 linked ubiquitination 0.353186312061849 0.1180808437935399 0.9060036016915528 1.0 0.9995097967416036 7 Q16763 1 +Inositol phosphate mediated signaling 0.3736167079494661 0.1165178933957622 0.9072421058055556 1.0 0.9999802444405308 6 P23634,P42345 2 +Calcineurin mediated signaling 0.3736167079494661 0.1165178933957622 0.9072421058055556 1.0 0.9999802444405308 6 P23634,P42345 2 +Regulation of calcineurin mediated signaling 0.3736167079494661 0.1165178933957622 0.9072421058055556 1.0 0.9999802444405308 6 P23634,P42345 2 +Process utilizing autophagic mechanism 0.2836620236206304 0.1137589799130456 0.9094288567192546 1.0 1.0 117 Q93050,Q9Y263,P61421,Q5MNZ6,Q9UID3,P10619,Q9Y487,O15118,Q969Q5,Q66K74,Q13501,Q96AX1,Q86Y82,O75844,P51809,P04062,Q96HS1,Q7Z6Z7,O15269,O75436,O95721,Q9Y3E7,P42345,O43464 24 +Positive regulation of translation 0.300309004077132 0.1133987645169898 0.9097144191671372 1.0 1.0 51 Q04637,Q96P11,Q7Z478,Q06787,Q07021,Q7Z739,P42345,Q567V2,Q13217,P51114,O60506,O00571 12 +Activated t cell proliferation 0.3768276346041453 0.1128540493072553 0.9101462668544112 1.0 1.0 4 P09429 1 +Transcription initiation from rna polymerase i promoter 0.371021434048717 0.1123546040838076 0.9105422480400868 1.0 1.0 6 O15160 1 +Rna polymerase i preinitiation complex assembly 0.371021434048717 0.1123546040838076 0.9105422480400868 1.0 1.0 6 O15160 1 +Autophagosome organization 0.3055653391830948 0.1120136196470176 0.9108126076175664 1.0 1.0 18 P04062,Q5MNZ6 2 +Negative regulation of mrna metabolic process 0.3008687641266845 0.1117111524685739 0.9110524362933328 1.0 1.0 38 P35637,Q07021,Q06787,P26368,Q92804,Q9Y2W1 6 +Dna modification 0.3001863239456391 0.1114649638365249 0.9112476472370517 1.0 1.0 24 O75844,Q9NQT5,Q8NB78,Q03164,P27695,Q9UIF9,P38398 7 +Intestinal hexose absorption 0.3365973072215407 0.1114317687444746 0.911273969111283 1.0 1.0 2 Q14651 1 +Establishment of centrosome localization 0.3365973072215396 0.111431768744473 0.9112739691112844 1.0 1.0 2 P43034 1 +Regulation of chromosome condensation 0.3263803680981535 0.1070882156503045 0.9147189959537576 1.0 1.0 8 Q9NTJ3,Q15021,Q7Z5K2,O60264,Q9BPX3,O95347,Q9UIG0 7 +Wound healing 0.2987955578987805 0.1061299276033943 0.9154792664381652 1.0 1.0 45 P55011,Q8WTV0,P42785,Q9Y624,P05556 5 +Actin filament network formation 0.3730612244897908 0.1056287752704629 0.9158768931006483 1.0 1.0 3 Q14651,P12814 2 +Positive regulation of lipase activity 0.3456591699336235 0.1048857138061787 0.9164664951676338 1.0 1.0 7 Q9Y263 1 +Glucocorticoid metabolic process 0.3711719069007803 0.1048397766762234 0.9165029467281898 1.0 1.0 4 Q9UNE7,P51608,Q04917 3 +Activation of gtpase activity 0.306048542360616 0.1045488917772778 0.9167337708042124 1.0 1.0 15 P84095,Q4KMP7 2 +Nuclear membrane reassembly 0.345086247132745 0.1039150384164627 0.9172367727885604 1.0 1.0 7 Q86XL3,Q9Y3E7,Q9UNZ2 3 +Developmental induction 0.3304773561811487 0.1029042312990692 0.9180389794407896 1.0 1.0 2 Q96C57 1 +Positive regulation of neuroblast proliferation 0.3304773561811479 0.1029042312990681 0.9180389794407906 1.0 1.0 2 O60341 1 +Mesenchymal to epithelial transition 0.3304773561811476 0.1029042312990678 0.9180389794407908 1.0 1.0 2 P80723 1 +Metanephros morphogenesis 0.3304773561811476 0.1029042312990678 0.9180389794407908 1.0 1.0 2 P80723 1 +Digestive tract morphogenesis 0.3304773561811464 0.1029042312990661 0.9180389794407922 1.0 1.0 2 Q6KC79 1 +Genitalia morphogenesis 0.3304773561811464 0.1029042312990661 0.9180389794407922 1.0 1.0 2 Q6KC79 1 +Hematopoietic stem cell homeostasis 0.3694367638433108 0.102465265769267 0.9183873816029048 1.0 1.0 4 Q14157 1 +Negative regulation of jun kinase activity 0.3292533659730683 0.1012730257525291 0.9193337284151386 1.0 1.0 2 P31689 1 +Negative regulation of vascular associated smooth muscle cell differentiation 0.3292533659730677 0.1012730257525282 0.9193337284151392 1.0 1.0 2 P26358 1 +Cardiac epithelial to mesenchymal transition 0.3292533659730664 0.1012730257525266 0.9193337284151406 1.0 1.0 2 Q9NQC3 1 +Relaxation of muscle 0.3681336336820399 0.1007078238237365 0.9197824004403006 1.0 1.0 4 P05026 1 +Positive regulation of cell cycle phase transition 0.2988727274116525 0.1001967432211492 0.9201881315377912 1.0 1.0 38 P05067,O75179 2 +Arf protein signal transduction 0.3685816681082406 0.0998967623320796 0.9204262867794236 1.0 1.0 3 Q15555 1 +Negative regulation of reproductive process 0.3626925760210017 0.0998603738116238 0.920455176161804 1.0 1.0 5 P35579,Q13162 2 +Positive regulation of exosomal secretion 0.3670886075949419 0.0993144579701346 0.9208885993695456 1.0 1.0 4 Q8WUM4,P51149,Q99816 3 +Escrt complex disassembly 0.3669387755101995 0.0978600402952566 0.9220434308561531 1.0 1.0 3 Q8WUX9,P53990 2 +Negative regulation of blood vessel endothelial cell migration 0.3610954338794097 0.0972400118628695 0.92253579371536 1.0 1.0 6 P23634,P09429,P67870 3 +Organ growth 0.3009855562753077 0.0938208311701949 0.9252514837915422 1.0 1.0 16 Q96HC4,O75844,Q12802 3 +Positive regulation of stem cell differentiation 0.3582982364712754 0.0937606108266611 0.9252993218021844 1.0 1.0 5 Q9Y6C9 1 +Intracellular protein transport 0.317529380795279 0.0930969602199858 0.9258265323427128 1.0 1.0 254 Q6ZWJ1,Q9C0E2,Q9H4M9,P61981,P55060,O00410,P31751,Q9Y282,O60830,P55786,O95373,Q14108,Q9BVK6,Q06481,Q8TEX9,Q15904,P05026,P10619,Q99523,Q969Q5,O96008,Q9NS69,Q99747,O00170,P27348,Q13501,Q96AX1,Q9Y4C2,Q86Y82,Q7Z3T8,Q99595,Q9UI26,O14925,Q8N4H5,Q5SRE5,Q7Z6Z7,Q5W0Z9,Q9BW83,O75436,Q9BZH6,Q9Y678,O00165,O43865,P35606,Q92688,O43464,P50402,O95831,Q96CS3 49 +Cell communication by electrical coupling involved in cardiac conduction 0.3573089567978585 0.0924222395874205 0.9263625704125602 1.0 1.0 5 P30626,P05026 2 +Regulation of protein kinase activity 0.2908401081209801 0.0912376270198219 0.9273037775818348 1.0 1.0 75 P05067,Q13177,Q96A49,P61981,Q12802,P42345,O00410,Q9H7B4,P04062,P54132,O95373,Q9P287,Q15334 13 +Corpus callosum development 0.3600507945227468 0.0896987467012601 0.928526611916284 1.0 1.0 3 Q96P11 1 +Regulation of translational fidelity 0.3017309926463131 0.0888641916750756 0.9291898418302034 1.0 1.0 13 Q9BW92,Q99543 2 +Regulation of production of small rna involved in gene silencing by rna 0.3521001970434859 0.0855852479100621 0.9317961258889608 1.0 1.0 5 O75844 1 +Positive regulation of extracellular matrix organization 0.3560636994691742 0.085472806946466 0.9318855132552428 1.0 1.0 4 Q8NBJ5,O75122,Q7Z460 3 +Regulation of extracellular matrix organization 0.3560636994691742 0.085472806946466 0.9318855132552428 1.0 1.0 4 Q8NBJ5,O75122,Q7Z460 3 +Interstrand cross link repair 0.3560636994691699 0.085472806946461 0.9318855132552468 1.0 1.0 4 Q9H1E3,Q96B01,P55072 3 +Regulation of extracellular matrix disassembly 0.3559183673469331 0.0850911538075229 0.9321889230398086 1.0 1.0 3 O75122,Q7Z460 2 +Positive regulation of extracellular matrix disassembly 0.3559183673469331 0.0850911538075229 0.9321889230398086 1.0 1.0 3 O75122,Q7Z460 2 +Peptidyl lysine hydroxylation 0.3513888896720838 0.0836922487122277 0.9333011201557186 1.0 1.0 6 Q92791 1 +Actin filament severing 0.3509898083270892 0.0831611133497602 0.9337234326462052 1.0 1.0 6 Q13045 1 +Striated muscle cell proliferation 0.3540220498162553 0.0830794662116028 0.93378835298261 1.0 1.0 4 P06493,P10644,P52294 3 +Glomerular epithelium development 0.353877551020403 0.082894287013117 0.933935596711259 1.0 1.0 3 P80723,P46940 2 +Glomerulus development 0.353877551020403 0.082894287013117 0.933935596711259 1.0 1.0 3 P80723,P46940 2 +Positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway 0.2977608137075443 0.0828546965780968 0.9339670770160572 1.0 1.0 11 P67870 1 +Positive regulation of cytokine production 0.2955878163112844 0.0826114576788269 0.9341604905092376 1.0 1.0 48 P05067,P09429,P38398,O75955,P04439,P49755,Q9NUD5,P26583,Q9NUQ9,O14802,O00571,Q13546 12 +Regulation of dna strand elongation 0.3492647058823549 0.0820106617867953 0.9346382351379 1.0 1.0 5 Q9Y5K5,Q9Y230,Q9H1E3,O96019 4 +Negative regulation of nuclear transcribed mrna catabolic process nonsense mediated decay 0.3113015095879194 0.0800948543814297 0.9361618152099324 1.0 1.0 2 Q99729 1 +Regulation of megakaryocyte differentiation 0.3282797088623508 0.0775544317681943 0.9381824913299636 1.0 1.0 7 Q99873 1 +Megakaryocyte differentiation 0.3282797088623508 0.0775544317681943 0.9381824913299636 1.0 1.0 7 Q99873 1 +Regulation of receptor signaling pathway via stat 0.3450414558092147 0.0768771254543725 0.9387212949258236 1.0 1.0 5 Q13610 1 +Pyrimidine deoxyribonucleoside triphosphate metabolic process 0.3465635756536833 0.074778024203622 0.9403913269986915 1.0 1.0 4 P23919,P33316 2 +Regulation of atp dependent activity 0.2915345121679703 0.0710306050753418 0.943373397673013 1.0 1.0 23 Q5JTV8,P05026,Q8IXB1,P54709,Q8WXX5 5 +Regulation of sodium ion transport 0.2946044765070066 0.0706181946556327 0.9437016293234196 1.0 1.0 14 P54709,P05026 2 +Postsynaptic modulation of chemical synaptic transmission 0.3417721518987376 0.0698046801763239 0.9443491220252632 1.0 1.0 4 Q7L576,P38919,P40818 3 +Regulation of execution phase of apoptosis 0.3382972943036579 0.0691458567366833 0.9448735199528232 1.0 1.0 5 Q13177,P63167 2 +Negative regulation of mrna catabolic process 0.2911811131547739 0.0685875725173541 0.94531791126525 1.0 1.0 21 P35637,Q9Y2W1,Q92804,Q06787 4 +Positive regulation of intracellular transport 0.2928261856835697 0.0682555026767031 0.9455822451977252 1.0 1.0 55 Q9Y4C2,Q9C0E2,Q9H4M9,Q16630,O00410,P31751,Q9Y282,O43464,P50402,P55786,Q92688,Q7Z6Z7 12 +Microtubule organizing center localization 0.3370098039215709 0.067734293206462 0.9459971499570012 1.0 1.0 5 P49792,P33176,Q8WXH0,P43034 4 +Cilium organization 0.2929299947512715 0.0668982941864867 0.9466626710401348 1.0 1.0 47 P61421,Q4KMP7,Q9H4M9,Q9BZH6,O95721,Q92692,Q14203,O15439,A6NIH7 9 +Positive regulation of cell death 0.2864077959104439 0.066600567667426 0.946899693817675 1.0 1.0 97 Q13501,Q07021,O94813,P49427,Q15375,O43464,P11717 7 +Cortical cytoskeleton organization 0.2913086632070912 0.0665263832648443 0.9469587534245116 1.0 1.0 19 Q14651,P84095,Q9NQW6,Q15334 4 +Inositol metabolic process 0.2966136270909792 0.0663655712642833 0.9470867799018392 1.0 1.0 2 P51608 1 +Organelle disassembly 0.2900986480627017 0.065908024936627 0.9474510515016994 1.0 1.0 40 Q13501,P04062,Q9ULC4,O43464 4 +Positive regulation of multicellular organism growth 0.3352388730093946 0.0634649622338834 0.9493962590630324 1.0 1.0 4 Q14651,P15311,Q6KC79 3 +Epithelial cell differentiation involved in kidney development 0.3306122448979537 0.06136521846855 0.9510683517758765 1.0 1.0 3 P80723,P46940 2 +Cell differentiation involved in kidney development 0.3306122448979537 0.06136521846855 0.9510683517758765 1.0 1.0 3 P80723,P46940 2 +Polyadenylation dependent rna catabolic process 0.3314936759355992 0.0600551135422335 0.9521117396023902 1.0 1.0 4 Q15024 1 +Regulation of dephosphorylation 0.2895773230554866 0.059751802867716 0.952353312683364 1.0 1.0 25 P67870,Q14738,P04062 3 +Regulation of neuroblast proliferation 0.3307472437729695 0.0593946968376697 0.9526377369149056 1.0 1.0 4 O60341,P35221,P04637 3 +Kidney morphogenesis 0.3307472437729686 0.0593946968376689 0.9526377369149062 1.0 1.0 4 Q13418,P80723,O75844 3 +Positive regulation of protein exit from endoplasmic reticulum 0.28682170542635 0.0588457044350105 0.9530750046347276 1.0 1.0 2 Q9NR31 1 +Female meiosis chromosome segregation 0.3257142857142805 0.0576130959170528 0.9540568179678426 1.0 1.0 3 P33981,P53350 2 +Positive regulation of chromosome condensation 0.3259803921568649 0.056467700596252 0.9549692256445204 1.0 1.0 5 Q15021,Q9NTJ3,O95347,Q9BPX3 4 +Tor signaling 0.2881113052348775 0.0562165594157724 0.9551692895174004 1.0 1.0 16 P04062,Q96A49,Q6IAA8,O75844 4 +Lung epithelium development 0.3262788828766664 0.055572380306624 0.955682467813979 1.0 1.0 4 Q13155 1 +Keratinocyte development 0.3233973050224613 0.0532247684870215 0.9575528211829888 1.0 1.0 4 Q15149,Q9Y3B8,O75369 3 +Mrna 3 end processing 0.2929515139481302 0.0518229397352061 0.9586697768428812 1.0 1.0 34 P05067,Q16630 2 +Cell communication by electrical coupling 0.3085448200518082 0.0517394939455506 0.9587362677494636 1.0 1.0 7 P30626,P05026 2 +Positive regulation by host of viral genome replication 0.3202614379084989 0.0511929399701729 0.959171777557558 1.0 1.0 5 Q9H1E3,Q9H6S0,P11142,P23284 4 +Regulation of peptidyl lysine acetylation 0.2858674076702782 0.0507290786569503 0.9595414050568368 1.0 1.0 13 Q01105,Q03164,P38398 3 +Regulation of inositol 1 4 5 trisphosphate sensitive calcium release channel activity 0.2737658098735144 0.0506413173400684 0.95961133856965 1.0 1.0 2 P27695 1 +Embryonic brain development 0.3186274509803942 0.0497549260496059 0.960317685965932 1.0 1.0 5 P27635,Q9BVA1,P62995,P35222 4 +Stress granule assembly 0.2862174394369011 0.0496065599065731 0.9604359190206184 1.0 1.0 15 Q14157,Q7Z739,O00571 3 +Positive regulation of cilium assembly 0.3211447053085232 0.0490617186666229 0.960870110726742 1.0 1.0 6 Q15555 1 +Calcium mediated signaling 0.2854422567885288 0.0476434420696811 0.9620004095556508 1.0 1.0 15 Q9ULM6,P05026,O75844 3 +Iron sulfur cluster assembly 0.2890760357099864 0.0472743491484056 0.9622945716332592 1.0 1.0 8 Q6FI81 1 +Regulation of cell substrate junction organization 0.2855289657608728 0.0471222797655559 0.9624157703746192 1.0 1.0 17 O75122,Q7Z460,Q9H2G2,P60903,O75116,Q15555,Q96AC1,P63167 8 +Body morphogenesis 0.3036328959880093 0.0461506883714838 0.9631901455407303 1.0 1.0 7 Q6KC79,Q12797,O75122,Q7Z460 4 +Regulation of establishment of protein localization to mitochondrion 0.2840088627354155 0.0450736520551168 0.9640486026857108 1.0 1.0 16 P55786,Q7Z6Z7,O43464 3 +Regulation of nuclear transcribed mrna catabolic process nonsense mediated decay 0.3115557370355287 0.0445053671354477 0.96450157386244 1.0 1.0 4 Q99729,Q9Y5S9,P38919 3 +Amyloid beta clearance 0.3020971895058819 0.0444698227990483 0.9645299060889908 1.0 1.0 7 Q13547,P30533 2 +Lamellipodium organization 0.2835503130702798 0.0399255276122661 0.9681524992338102 1.0 1.0 22 O94813 1 +Morphogenesis of an epithelium 0.2886967455489461 0.0399138963324184 0.9681617722608076 1.0 1.0 48 P11233,O94813,Q15375,Q9UNS1 4 +Protein k63 linked ubiquitination 0.2806614591036604 0.0393913221315892 0.9685783984771752 1.0 1.0 13 O00571,Q9Y263,Q16763 3 +Tyrosine phosphorylation of stat protein 0.3032075452270178 0.0392081645455896 0.968724424277261 1.0 1.0 4 Q92769 1 +Receptor clustering 0.2824789606865356 0.0389887682803003 0.9688993434199948 1.0 1.0 8 Q15334 1 +Regulation of sodium ion transmembrane transport 0.2785478857829557 0.0387918882424197 0.9690563122130772 1.0 1.0 12 Q9UHD1,P05026,P54709,P23634,O43707 5 +Regulation of protein exit from endoplasmic reticulum 0.2869387755101985 0.0360872807989638 0.9712127641750832 1.0 1.0 3 Q8IWJ2,Q9NR31 2 +Mitochondrial fragmentation involved in apoptotic process 0.2820408163265245 0.0342584138763343 0.9726710863078094 1.0 1.0 3 O00429,Q96QK1 2 +Peroxisome proliferator activated receptor signaling pathway 0.2816530836157527 0.0341208817141331 0.9727807569790424 1.0 1.0 3 Q15120 1 +Response to nitrosative stress 0.2804081632653004 0.0336862925061358 0.9731273097653156 1.0 1.0 3 P31689,P11766 2 +Pigment granule organization 0.2923642302980863 0.0332938199296809 0.973440282011067 1.0 1.0 4 Q9BXS5,O00203,O14617 3 +Medium chain fatty acid metabolic process 0.2787755102040764 0.0331322987833062 0.973569086177858 1.0 1.0 3 P11310,O00154 2 +5 phosphoribose 1 diphosphate metabolic process 0.2742857142857082 0.0316992502782547 0.9747118927788754 1.0 1.0 3 O60256,P06737 2 +Regulation of cellular response to hypoxia 0.2710204081632602 0.0307369758450178 0.975479302624162 1.0 1.0 3 Q9Y4L1,O75116 2 +Synaptic vesicle budding 0.2636734693877502 0.0288015187204036 0.9770228896199724 1.0 1.0 3 O00203,O14617 2 +Regulation of vesicle size 0.2636734693877495 0.0288015187204033 0.9770228896199726 1.0 1.0 3 Q96CW1,P20339 2 +Positive regulation of amyloid beta formation 0.2636734693877495 0.0288015187204033 0.9770228896199726 1.0 1.0 3 P49840,O75116 2 +Cellular response to heat 0.2797290754687062 0.028258796779438 0.9774557428715552 1.0 1.0 21 O75340,Q92769,Q99615,Q99543,P42345,O43464,P17612,P25685 8 +Synaptic vesicle transport 0.2644289807613604 0.0269005689969163 0.9785390396888364 1.0 1.0 10 P33176,Q92572,Q00535,P35222,Q9Y2T2,P50570,Q96A57,O00203,O14617 9 +Synaptic vesicle localization 0.2644289807613604 0.0269005689969163 0.9785390396888364 1.0 1.0 10 P33176,Q92572,Q00535,P35222,Q9Y2T2,P50570,Q96A57,O00203,O14617 9 +Axonal transport 0.276594667279595 0.0259880337326274 0.9792668829268798 1.0 1.0 16 Q92572,Q14203,P27695,O14617,O95239,Q9UH62 6 +Regulation of camp dependent protein kinase activity 0.2739893834218099 0.0254883585536964 0.9796654340005312 1.0 1.0 4 P23634,P10644,P13861 3 +Response to organic cyclic compound 0.2891137724496593 0.0240175604560771 0.980838601528756 1.0 1.0 141 P05067,Q13126,P49721,O94813,P08195,Q9NUD5,O15118,Q9H7B4,P04062,P54132,Q92542,O95831,P35613,P16278 14 +Regulation of postsynaptic membrane neurotransmitter receptor levels 0.2797601600937509 0.0234489687083113 0.9812921443485578 1.0 1.0 7 Q15334 1 +Mrna splice site selection 0.2754245363283545 0.0231006924622255 0.9815699533295824 1.0 1.0 16 Q15428,Q07955,Q9UHX1,Q13243 4 +Negative regulation of innate immune response 0.2611930015767882 0.0222626762643943 0.9822384215241876 1.0 1.0 10 Q7Z739,P01889 2 +Amyloid beta clearance by transcytosis 0.2637811351572106 0.0221955222750149 0.9822919894190364 1.0 1.0 4 P30533,P20339,Q00610 3 +Pyrimidine deoxyribonucleotide metabolic process 0.2850424733916467 0.0214144313214572 0.9829150616759824 1.0 1.0 6 P23919 1 +Regulation of nuclease activity 0.2769422572356884 0.0212312715020843 0.9830611688492044 1.0 1.0 7 P26583 1 +Regulation of membrane repolarization 0.2728758169934664 0.0206305199860147 0.9835403942151616 1.0 1.0 5 P62258,Q96PU5,P21333,O75844 4 +Regulation of calcium mediated signaling 0.2743254292722852 0.0192539659501291 0.9846385069632044 1.0 1.0 7 Q9UHD1,P49841,P26599,P42345,Q8IWX8,P23634 6 +Negative regulation of nf kappab transcription factor activity 0.2516366612111334 0.0190821699986452 0.9847755551212578 1.0 1.0 9 Q9UHD1,Q93009,P32119,Q96JB5,Q96J02,Q9UN86,Q9UNN5,O75832 8 +Positive regulation of calcium ion transport 0.2505266105846179 0.0178243744369443 0.9857789598585848 1.0 1.0 9 P30626,P20020,P05026 3 +Stem cell division 0.2417233644756932 0.0171254538104509 0.9863365326841056 1.0 1.0 4 Q01085 1 +Positive regulation of transcription of nucleolar large rrna by rna polymerase i 0.2704163571993506 0.0164442938375637 0.9868799431459584 1.0 1.0 7 P42345 1 +R loop disassembly 0.2351980400163382 0.016065669512405 0.987182001739277 1.0 1.0 4 P78362,Q9NY93,Q9BUQ8 3 +Dephosphorylation 0.2843216400436582 0.0158266001856811 0.9873727272132736 1.0 1.0 57 P11117,P04062 2 +Regulation of nucleotide biosynthetic process 0.271352676747036 0.0142547375605358 0.98862675015286 1.0 1.0 6 P09874,P55072,O75746,Q15120,P00403 5 +Regulation of deoxyribonuclease activity 0.2549783293415449 0.0141192312982493 0.9887348576273762 1.0 1.0 5 P09429 1 +Metanephros development 0.2483660130718977 0.0122495537240637 0.9902265146285872 1.0 1.0 5 Q6KC79,P35222,P80723,P15121 4 +Protein localization to cytoplasmic stress granule 0.2668573763792397 0.0122459609002898 0.9902293810722038 1.0 1.0 6 P31483,P67809,P05455,Q92499,O00571 5 +Regulation of neurotransmitter transport 0.2638393865556969 0.0122253204946523 0.9902458485004676 1.0 1.0 12 P05556,O75955,Q06787 3 +Regulation of mitotic cell cycle 0.275059564572642 0.0120291160749722 0.9904023854661166 1.0 1.0 106 P05067,O75179,Q99538,P54132,Q06481 5 +Trna catabolic process 0.2660400490396417 0.0118977850226012 0.990507164986574 1.0 1.0 6 Q9BQ52,Q9NQT5,Q99575,Q08J23,Q15024 5 +Protein dna complex assembly 0.2821572058929762 0.0117823484039045 0.9905992636265816 1.0 1.0 43 P55209,P25440,Q99733,P26583,Q9H7B4,Q01105,Q15020,O15160,Q92688,Q9UIF9,Q9NRG0,Q8WXX5 12 +Cerebral cortex radially oriented cell migration 0.2656313853698423 0.0117256256230636 0.9906445187314096 1.0 1.0 6 Q96N66,Q8WXH0,P35222,Q9NQC3,P43034 5 +Telencephalon glial cell migration 0.2656313853698423 0.0117256256230636 0.9906445187314096 1.0 1.0 6 Q96N66,Q8WXH0,P35222,Q9NQC3,P43034 5 +Integrin mediated signaling pathway 0.2624840512645 0.0099999013181199 0.9920213661035486 1.0 1.0 12 Q96AC1,P05556 2 +Dna dealkylation 0.2385620915032703 0.0099325443626976 0.9920751065093674 1.0 1.0 5 Q13263,P27695,Q93009,Q9C0B1 4 +Regulation of cell division 0.2721656737382124 0.0077709043632947 0.993799777787204 1.0 1.0 20 P54132,O43663 2 +Histone h3 k9 methylation 0.2551992489242936 0.0070587065370026 0.9943680138041956 1.0 1.0 7 P26358,P51608,P38398 3 +Regulation of histone h3 k9 methylation 0.2551992489242936 0.0070587065370026 0.9943680138041956 1.0 1.0 7 P26358,P51608,P38398 3 +Regulation of exit from mitosis 0.2530767776598037 0.007032079715122 0.9943892584070048 1.0 1.0 6 Q9NQW6 1 +Cellular response to abiotic stimulus 0.2831287163292248 0.0068788716285859 0.9945114978167986 1.0 1.0 48 Q9C0C2,Q06787,O75844,Q9NXR7,P58546,Q9Y624,P31751,P54132,Q15555,Q9H1E3,P38398 11 +Epiboly 0.2506280374987022 0.0046889991338893 0.996258733695148 1.0 1.0 7 Q96AC1,P42345,Q7Z460 3 +Morphogenesis of an epithelial sheet 0.2506280374987022 0.0046889991338893 0.996258733695148 1.0 1.0 7 Q96AC1,P42345,Q7Z460 3 +Regulation of multicellular organismal development 0.2863094095305265 0.0042737811990968 0.9965900263456392 1.0 1.0 139 P55209,Q8N0X7,O96013,P26583,Q13573,Q06481,Q13546,Q13547,P09429,O00763,O94813,Q96G23,Q15375,Q92896,P05556,P55011,O75844,Q9UQB8,Q68CQ4,P01889,Q9Y624,P20020,P38398,Q96P11,P42345,O00165,Q99873 27 +Positive regulation of insulin secretion 0.2400535880282782 0.0032620195847828 0.997397289552074 1.0 1.0 6 P30626 1 +Phenol containing compound metabolic process 0.2468895184876083 0.0028938791400548 0.9976910217360916 1.0 1.0 7 P58546 1 +Anterograde axonal transport 0.2446160498561305 0.0014299390558539 0.9988590740932586 1.0 1.0 10 O95239,P27695,Q92572,O14617 4 +Protein hydroxylation 0.2656527831236165 0.0003261845991047 0.9997397423490176 1.0 1.0 16 Q92791,P13674,O15460,O60568,Q13162 5 diff --git a/msigdb_gobp/selections.json b/msigdb_gobp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..fc0ca915293b88e2b1e48649d56bc418d5abc243 --- /dev/null +++ b/msigdb_gobp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["10 formyltetrahydrofolate metabolic process", "2 oxoglutarate metabolic process", "2fe 2s cluster assembly", "3 phosphoadenosine 5 phosphosulfate biosynthetic process", "3 phosphoadenosine 5 phosphosulfate metabolic process", "3 utr mediated mrna destabilization", "3 utr mediated mrna stabilization", "5 phosphoribose 1 diphosphate metabolic process", "5s class rrna transcription by rna polymerase iii", "Abscission", "Acetyl coa biosynthetic process", "Acetyl coa biosynthetic process from pyruvate", "Acetyl coa metabolic process", "Acid secretion", "Acidic amino acid transport", "Acrosome assembly", "Actin crosslink formation", "Actin cytoskeleton reorganization", "Actin filament based movement", "Actin filament based process", "Actin filament based transport", "Actin filament bundle organization", "Actin filament depolymerization", "Actin filament network formation", "Actin filament organization", "Actin filament polymerization", "Actin filament severing", "Actin mediated cell contraction", "Actin modification", "Actin myosin filament sliding", "Actin nucleation", "Actin polymerization dependent cell motility", "Actin polymerization or depolymerization", "Action potential", "Activated t cell proliferation", "Activation induced cell death of t cells", "Activation of adenylate cyclase activity", "Activation of cysteine type endopeptidase activity", "Activation of cysteine type endopeptidase activity involved in apoptotic process", "Activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome c", "Activation of gtpase activity", "Activation of immune response", "Activation of innate immune response", "Activation of nf kappab inducing kinase activity", "Activation of phospholipase c activity", "Activation of phospholipase d activity", "Activation of protein kinase activity", "Activation of protein kinase b activity", "Activation of protein kinase c activity", "Activin receptor signaling pathway", "Actomyosin contractile ring organization", "Actomyosin structure organization", "Acute inflammatory response", "Acute inflammatory response to antigenic stimulus", "Acute phase response", "Acyl carnitine transmembrane transport", "Acylglycerol homeostasis", "Adaptation of signaling pathway", "Adaptive immune response", "Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", "Adaptive thermogenesis", "Adenosine metabolic process", "Adenosine to inosine editing", "Adenylate cyclase activating adrenergic receptor signaling pathway", "Adenylate cyclase activating adrenergic receptor signaling pathway involved in heart process", "Adenylate cyclase activating dopamine receptor signaling pathway", "Adenylate cyclase activating g protein coupled receptor signaling pathway", "Adenylate cyclase inhibiting dopamine receptor signaling pathway", "Adenylate cyclase inhibiting g protein coupled receptor signaling pathway", "Adenylate cyclase modulating g protein coupled receptor signaling pathway", "Adherens junction assembly", "Adherens junction maintenance", "Adherens junction organization", "Adhesion of symbiont to host", "Adhesion of symbiont to host cell", "Adiponectin activated signaling pathway", "Adipose tissue development", "Adp biosynthetic process", "Adp metabolic process", "Adp transport", "Adrenergic receptor signaling pathway", "Adult behavior", "Adult locomotory behavior", "Aerobic respiration", "Aggrephagy", "Aggresome assembly", "Aging", "Alanine transport", "Alcohol biosynthetic process", "Alcohol catabolic process", "Alcohol metabolic process", "Aldehyde biosynthetic process", "Aldehyde catabolic process", "Alditol biosynthetic process", "Alditol catabolic process", "Alditol metabolic process", "Alditol phosphate metabolic process", "Alkanesulfonate metabolic process", "Allantoin metabolic process", "Alpha amino acid catabolic process", "Alpha amino acid metabolic process", "Alpha beta t cell activation", "Alpha beta t cell differentiation", "Alpha beta t cell proliferation", "Alpha ketoglutarate transport", "Alpha linolenic acid metabolic process", "Alternative mrna splicing via spliceosome", "Ameboidal type cell migration", "Amelogenesis", "Amide biosynthetic process", "Amide transport", "Amine biosynthetic process", "Amine catabolic process", "Amine metabolic process", "Amine transport", "Amino acid activation", "Amino acid betaine biosynthetic process", "Amino acid betaine metabolic process", "Amino acid betaine transport", "Amino acid homeostasis", "Amino acid import", "Amino acid import across plasma membrane", "Amino acid neurotransmitter reuptake", "Amino acid salvage", "Amino acid transmembrane transport", "Amino acid transport", "Amino sugar biosynthetic process", "Amino sugar catabolic process", "Amino sugar metabolic process", "Aminoacyl trna metabolism involved in translational fidelity", "Aminoglycan biosynthetic process", "Aminoglycan catabolic process", "Aminoglycan metabolic process", "Aminoglycoside antibiotic metabolic process", "Aminophospholipid transport", "Ammonium ion metabolic process", "Ammonium transmembrane transport", "Amp biosynthetic process", "Amp metabolic process", "Amp salvage", "Ampa glutamate receptor clustering", "Amygdala development", "Amyloid beta clearance", "Amyloid beta clearance by cellular catabolic process", "Amyloid beta clearance by transcytosis", "Amyloid beta formation", "Amyloid beta metabolic process", "Amyloid fibril formation", "Amyloid precursor protein biosynthetic process", "Amyloid precursor protein catabolic process", "Amyloid precursor protein metabolic process", "Anagen", "Anaphase promoting complex dependent catabolic process", "Anatomical structure arrangement", "Anatomical structure formation involved in morphogenesis", "Anatomical structure homeostasis", "Anatomical structure maturation", "Androgen metabolic process", "Androgen receptor signaling pathway", "Angiogenesis involved in wound healing", "Angiotensin activated signaling pathway", "Animal organ formation", "Animal organ maturation", "Animal organ morphogenesis", "Animal organ regeneration", "Anion homeostasis", "Anion transmembrane transport", "Anion transport", "Anoikis", "Anterior head development", "Anterior posterior axis specification", "Anterior posterior pattern specification", "Anterograde axonal transport", "Anterograde axonal transport of mitochondrion", "Anterograde dendritic transport", "Anterograde dendritic transport of neurotransmitter receptor complex", "Anterograde neuronal dense core vesicle transport", "Antibacterial humoral response", "Antigen processing and presentation", "Antigen processing and presentation of endogenous antigen", "Antigen processing and presentation of endogenous peptide antigen", "Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway", "Antigen processing and presentation of exogenous antigen", "Antigen processing and presentation of exogenous peptide antigen", "Antigen processing and presentation of exogenous peptide antigen via mhc class i", "Antigen processing and presentation of exogenous peptide antigen via mhc class ii", "Antigen processing and presentation of lipid antigen via mhc class ib", "Antigen processing and presentation of peptide antigen", "Antigen processing and presentation of peptide antigen via mhc class i", "Antigen processing and presentation of peptide antigen via mhc class ib", "Antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii", "Antigen processing and presentation via mhc class ib", "Antigen receptor mediated signaling pathway", "Antimicrobial humoral immune response mediated by antimicrobial peptide", "Antimicrobial humoral response", "Antiviral innate immune response", "Aorta development", "Aorta morphogenesis", "Aortic valve morphogenesis", "Apical junction assembly", "Apical protein localization", "Apolipoprotein a i mediated signaling pathway", "Apoptotic cell clearance", "Apoptotic chromosome condensation", "Apoptotic dna fragmentation", "Apoptotic mitochondrial changes", "Apoptotic process involved in development", "Apoptotic process involved in heart morphogenesis", "Apoptotic process involved in morphogenesis", "Apoptotic signaling pathway", "Appendage development", "Appendage morphogenesis", "Arachidonic acid metabolic process", "Arachidonic acid secretion", "Arf protein signal transduction", "Arginine catabolic process", "Arginine metabolic process", "Aromatic amino acid family catabolic process", "Aromatic amino acid family metabolic process", "Aromatic amino acid transport", "Arp2 3 complex mediated actin nucleation", "Artery development", "Artery morphogenesis", "Asparagine metabolic process", "Aspartate family amino acid biosynthetic process", "Aspartate family amino acid catabolic process", "Aspartate family amino acid metabolic process", "Aspartate metabolic process", "Aspartate transmembrane transport", "Associative learning", "Astral microtubule organization", "Astrocyte activation", "Astrocyte cell migration", "Astrocyte development", "Astrocyte differentiation", "Asymmetric cell division", "Asymmetric neuroblast division", "Atf6 mediated unfolded protein response", "Atp biosynthetic process", "Atp metabolic process", "Atp synthesis coupled electron transport", "Atp synthesis coupled proton transport", "Atp transport", "Atrial cardiac muscle cell membrane repolarization", "Atrial cardiac muscle cell to av node cell signaling", "Atrial septum development", "Atrial septum morphogenesis", "Attachment of gpi anchor to protein", "Attachment of mitotic spindle microtubules to kinetochore", "Attachment of spindle microtubules to kinetochore", "Auditory receptor cell development", "Auditory receptor cell morphogenesis", "Autonomic nervous system development", "Autophagic cell death", "Autophagosome maturation", "Autophagosome membrane docking", "Autophagosome organization", "Autophagy of mitochondrion", "Autophagy of nucleus", "Axial mesoderm development", "Axis elongation", "Axis specification", "Axo dendritic protein transport", "Axo dendritic transport", "Axon choice point recognition", "Axon development", "Axon ensheathment in central nervous system", "Axon extension", "Axon midline choice point recognition", "Axonal fasciculation", "Axonal transport", "Axonal transport of mitochondrion", "Axonemal dynein complex assembly", "Axoneme assembly", "Axonogenesis involved in innervation", "Azole transmembrane transport", "B cell activation", "B cell activation involved in immune response", "B cell apoptotic process", "B cell differentiation", "B cell homeostasis", "B cell lineage commitment", "B cell mediated immunity", "B cell proliferation", "Barbed end actin filament capping", "Base conversion or substitution editing", "Base excision repair", "Base excision repair ap site formation", "Base excision repair gap filling", "Basement membrane assembly", "Basement membrane organization", "Behavior", "Behavioral response to cocaine", "Behavioral response to ethanol", "Behavioral response to pain", "Benzene containing compound metabolic process", "Bergmann glial cell differentiation", "Bicarbonate transport", "Bile acid and bile salt transport", "Bile acid biosynthetic process", "Bile acid metabolic process", "Bile acid secretion", "Binding of sperm to zona pellucida", "Biological adhesion", "Biological phase", "Biological process involved in interaction with host", "Biological process involved in interaction with symbiont", "Biological process involved in interspecies interaction between organisms", "Biological process involved in intraspecies interaction between organisms", "Biological process involved in symbiotic interaction", "Biomineralization", "Blastocyst development", "Blastocyst formation", "Blastocyst growth", "Blastoderm segmentation", "Bleb assembly", "Blood vessel endothelial cell migration", "Blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Blood vessel maturation", "Blood vessel morphogenesis", "Blood vessel remodeling", "Body fluid secretion", "Body morphogenesis", "Bone cell development", "Bone development", "Bone growth", "Bone marrow development", "Bone maturation", "Bone mineralization", "Bone morphogenesis", "Bone remodeling", "Bone resorption", "Box c d snornp assembly", "Bradykinin catabolic process", "Brain morphogenesis", "Brainstem development", "Branched chain amino acid biosynthetic process", "Branched chain amino acid catabolic process", "Branched chain amino acid metabolic process", "Branched chain amino acid transport", "Branching involved in blood vessel morphogenesis", "Branching involved in labyrinthine layer morphogenesis", "Branching involved in mammary gland duct morphogenesis", "Branching morphogenesis of a nerve", "Branching morphogenesis of an epithelial tube", "Brown fat cell differentiation", "Bundle of his cell to purkinje myocyte communication", "C 5 methylation of cytosine", "C terminal protein amino acid modification", "C21 steroid hormone biosynthetic process", "C21 steroid hormone metabolic process", "C4 dicarboxylate transport", "Calcineurin mediated signaling", "Calcium import into the mitochondrion", "Calcium ion export", "Calcium ion export across plasma membrane", "Calcium ion import", "Calcium ion import into cytosol", "Calcium ion import into sarcoplasmic reticulum", "Calcium ion regulated exocytosis", "Calcium ion regulated exocytosis of neurotransmitter", "Calcium ion transmembrane transport", "Calcium ion transmembrane transport via high voltage gated calcium channel", "Calcium ion transport", "Calcium ion transport into cytosol", "Calcium mediated signaling", "Calcium mediated signaling using intracellular calcium source", "Calmodulin dependent kinase signaling pathway", "Camera type eye development", "Camera type eye morphogenesis", "Camera type eye photoreceptor cell differentiation", "Camp mediated signaling", "Cannabinoid signaling pathway", "Canonical wnt signaling pathway", "Canonical wnt signaling pathway involved in heart development", "Canonical wnt signaling pathway involved in osteoblast differentiation", "Canonical wnt signaling pathway involved in regulation of cell proliferation", "Cap dependent translational initiation", "Carbohydrate biosynthetic process", "Carbohydrate catabolic process", "Carbohydrate derivative biosynthetic process", "Carbohydrate derivative catabolic process", "Carbohydrate derivative metabolic process", "Carbohydrate derivative transport", "Carbohydrate homeostasis", "Carbohydrate mediated signaling", "Carbohydrate metabolic process", "Carbohydrate phosphorylation", "Carbohydrate transmembrane transport", "Carbohydrate transport", "Carboxylic acid transport", "Cardiac atrium development", "Cardiac atrium morphogenesis", "Cardiac cell development", "Cardiac chamber development", "Cardiac chamber morphogenesis", "Cardiac conduction", "Cardiac conduction system development", "Cardiac epithelial to mesenchymal transition", "Cardiac left ventricle morphogenesis", "Cardiac muscle cell action potential", "Cardiac muscle cell action potential involved in contraction", "Cardiac muscle cell cardiac muscle cell adhesion", "Cardiac muscle cell contraction", "Cardiac muscle cell differentiation", "Cardiac muscle cell membrane repolarization", "Cardiac muscle cell proliferation", "Cardiac muscle contraction", "Cardiac muscle tissue development", "Cardiac muscle tissue morphogenesis", "Cardiac neural crest cell development involved in outflow tract morphogenesis", "Cardiac neural crest cell differentiation involved in heart development", "Cardiac neural crest cell migration involved in outflow tract morphogenesis", "Cardiac septum development", "Cardiac septum morphogenesis", "Cardiac ventricle development", "Cardiac ventricle morphogenesis", "Cardioblast differentiation", "Cardioblast proliferation", "Cardiocyte differentiation", "Cardiolipin acyl chain remodeling", "Cardiolipin biosynthetic process", "Cardiolipin metabolic process", "Carnitine metabolic process", "Carnitine transport", "Cartilage development", "Cartilage development involved in endochondral bone morphogenesis", "Catechol containing compound biosynthetic process", "Catechol containing compound catabolic process", "Catechol containing compound metabolic process", "Catecholamine uptake", "Catecholamine uptake involved in synaptic transmission", "Cation transmembrane transport", "Cation transport", "Caveola assembly", "Caveolin mediated endocytosis", "Cd4 positive alpha beta t cell activation", "Cd4 positive alpha beta t cell differentiation", "Cd4 positive alpha beta t cell proliferation", "Cd4 positive or cd8 positive alpha beta t cell lineage commitment", "Cd40 signaling pathway", "Cd8 positive alpha beta t cell activation", "Cd8 positive alpha beta t cell proliferation", "Cdc42 protein signal transduction", "Cdp choline pathway", "Cdp diacylglycerol metabolic process", "Cell activation", "Cell activation involved in immune response", "Cell adhesion mediated by integrin", "Cell adhesion molecule production", "Cell aging", "Cell cell adhesion", "Cell cell adhesion mediated by cadherin", "Cell cell adhesion mediated by integrin", "Cell cell adhesion via plasma membrane adhesion molecules", "Cell cell junction assembly", "Cell cell junction maintenance", "Cell cell junction organization", "Cell cell recognition", "Cell cell signaling", "Cell cell signaling by wnt", "Cell cell signaling involved in cardiac conduction", "Cell chemotaxis", "Cell communication by electrical coupling", "Cell communication by electrical coupling involved in cardiac conduction", "Cell communication involved in cardiac conduction", "Cell cycle", "Cell cycle checkpoint signaling", "Cell cycle dna replication", "Cell cycle dna replication initiation", "Cell cycle g1 s phase transition", "Cell cycle g2 m phase transition", "Cell cycle phase transition", "Cell cycle process", "Cell death in response to hydrogen peroxide", "Cell death in response to oxidative stress", "Cell differentiation in hindbrain", "Cell differentiation in spinal cord", "Cell differentiation involved in embryonic placenta development", "Cell differentiation involved in kidney development", "Cell differentiation involved in metanephros development", "Cell differentiation involved in phenotypic switching", "Cell division", "Cell fate commitment", "Cell fate commitment involved in formation of primary germ layer", "Cell fate determination", "Cell fate specification", "Cell growth", "Cell junction assembly", "Cell junction disassembly", "Cell junction maintenance", "Cell junction organization", "Cell killing", "Cell matrix adhesion", "Cell maturation", "Cell migration", "Cell migration in hindbrain", "Cell migration involved in gastrulation", "Cell migration involved in heart development", "Cell migration involved in sprouting angiogenesis", "Cell morphogenesis", "Cell morphogenesis involved in differentiation", "Cell morphogenesis involved in neuron differentiation", "Cell motility involved in cerebral cortex radial glia guided migration", "Cell part morphogenesis", "Cell projection assembly", "Cell projection organization", "Cell proliferation in forebrain", "Cell proliferation in hindbrain", "Cell proliferation involved in heart morphogenesis", "Cell recognition", "Cell redox homeostasis", "Cell substrate adhesion", "Cell substrate junction organization", "Cell surface receptor signaling pathway involved in cell cell signaling", "Cell surface receptor signaling pathway involved in heart development", "Cell volume homeostasis", "Cellular aldehyde metabolic process", "Cellular amide metabolic process", "Cellular amino acid biosynthetic process", "Cellular amino acid catabolic process", "Cellular amino acid metabolic process", "Cellular anion homeostasis", "Cellular carbohydrate biosynthetic process", "Cellular carbohydrate catabolic process", "Cellular carbohydrate metabolic process", "Cellular component assembly involved in morphogenesis", "Cellular component disassembly", "Cellular component disassembly involved in execution phase of apoptosis", "Cellular component maintenance", "Cellular component morphogenesis", "Cellular copper ion homeostasis", "Cellular defense response", "Cellular detoxification of aldehyde", "Cellular extravasation", "Cellular glucan metabolic process", "Cellular glucose homeostasis", "Cellular homeostasis", "Cellular hormone metabolic process", "Cellular hyperosmotic response", "Cellular hyperosmotic salinity response", "Cellular ion homeostasis", "Cellular iron ion homeostasis", "Cellular ketone metabolic process", "Cellular lipid catabolic process", "Cellular lipid metabolic process", "Cellular macromolecule biosynthetic process", "Cellular macromolecule localization", "Cellular metabolic compound salvage", "Cellular modified amino acid biosynthetic process", "Cellular modified amino acid catabolic process", "Cellular modified amino acid metabolic process", "Cellular monovalent inorganic anion homeostasis", "Cellular monovalent inorganic cation homeostasis", "Cellular nitrogen compound catabolic process", "Cellular oxidant detoxification", "Cellular pigmentation", "Cellular polysaccharide catabolic process", "Cellular potassium ion homeostasis", "Cellular process involved in reproduction in multicellular organism", "Cellular protein catabolic process", "Cellular respiration", "Cellular response to abiotic stimulus", "Cellular response to acid chemical", "Cellular response to acidic ph", "Cellular response to alcohol", "Cellular response to aldehyde", "Cellular response to alkaloid", "Cellular response to amyloid beta", "Cellular response to antibiotic", "Cellular response to arsenic containing substance", "Cellular response to atp", "Cellular response to biotic stimulus", "Cellular response to brain derived neurotrophic factor stimulus", "Cellular response to cadmium ion", "Cellular response to calcium ion", "Cellular response to camp", "Cellular response to carbohydrate stimulus", "Cellular response to chemical stress", "Cellular response to cold", "Cellular response to copper ion", "Cellular response to corticosteroid stimulus", "Cellular response to dexamethasone stimulus", "Cellular response to dna damage stimulus", "Cellular response to dsrna", "Cellular response to electrical stimulus", "Cellular response to endogenous stimulus", "Cellular response to epinephrine stimulus", "Cellular response to estradiol stimulus", "Cellular response to estrogen stimulus", "Cellular response to ethanol", "Cellular response to ether", "Cellular response to exogenous dsrna", "Cellular response to external stimulus", "Cellular response to extracellular stimulus", "Cellular response to fatty acid", "Cellular response to fluid shear stress", "Cellular response to follicle stimulating hormone stimulus", "Cellular response to gamma radiation", "Cellular response to glucose starvation", "Cellular response to gonadotropin stimulus", "Cellular response to growth hormone stimulus", "Cellular response to heat", "Cellular response to heparin", "Cellular response to histamine", "Cellular response to hormone stimulus", "Cellular response to hydrogen peroxide", "Cellular response to hyperoxia", "Cellular response to increased oxygen levels", "Cellular response to indole 3 methanol", "Cellular response to inorganic substance", "Cellular response to insulin like growth factor stimulus", "Cellular response to insulin stimulus", "Cellular response to interferon alpha", "Cellular response to interferon beta", "Cellular response to interferon gamma", "Cellular response to interleukin 1", "Cellular response to ionizing radiation", "Cellular response to iron ion", "Cellular response to ketone", "Cellular response to leptin stimulus", "Cellular response to leucine", "Cellular response to leucine starvation", "Cellular response to light intensity", "Cellular response to light stimulus", "Cellular response to lipid", "Cellular response to lipoprotein particle stimulus", "Cellular response to lithium ion", "Cellular response to low density lipoprotein particle stimulus", "Cellular response to magnesium ion", "Cellular response to manganese ion", "Cellular response to mechanical stimulus", "Cellular response to mineralocorticoid stimulus", "Cellular response to molecule of bacterial origin", "Cellular response to muramyl dipeptide", "Cellular response to nitrogen compound", "Cellular response to nitrosative stress", "Cellular response to nutrient", "Cellular response to organic cyclic compound", "Cellular response to osmotic stress", "Cellular response to oxidised low density lipoprotein particle stimulus", "Cellular response to oxygen containing compound", "Cellular response to oxygen glucose deprivation", "Cellular response to oxygen levels", "Cellular response to oxygen radical", "Cellular response to parathyroid hormone stimulus", "Cellular response to peptide", "Cellular response to peptide hormone stimulus", "Cellular response to peptidoglycan", "Cellular response to ph", "Cellular response to potassium ion", "Cellular response to prostaglandin e stimulus", "Cellular response to prostaglandin stimulus", "Cellular response to radiation", "Cellular response to reactive nitrogen species", "Cellular response to reactive oxygen species", "Cellular response to retinoic acid", "Cellular response to salt", "Cellular response to salt stress", "Cellular response to sodium arsenite", "Cellular response to starvation", "Cellular response to steroid hormone stimulus", "Cellular response to sterol depletion", "Cellular response to stress", "Cellular response to testosterone stimulus", "Cellular response to thyroid hormone stimulus", "Cellular response to topologically incorrect protein", "Cellular response to toxic substance", "Cellular response to unfolded protein", "Cellular response to uv", "Cellular response to uv a", "Cellular response to uv c", "Cellular response to vascular endothelial growth factor stimulus", "Cellular response to virus", "Cellular response to vitamin", "Cellular response to vitamin d", "Cellular response to water stimulus", "Cellular response to x ray", "Cellular response to xenobiotic stimulus", "Cellular response to zinc ion", "Cellular senescence", "Cellular sodium ion homeostasis", "Cellular sphingolipid homeostasis", "Cellular transition metal ion homeostasis", "Cellular triglyceride homeostasis", "Cellular trivalent inorganic anion homeostasis", "Cenp a containing chromatin organization", "Central nervous system development", "Central nervous system maturation", "Central nervous system myelin formation", "Central nervous system neuron axonogenesis", "Central nervous system neuron development", "Central nervous system neuron differentiation", "Central nervous system projection neuron axonogenesis", "Centriole assembly", "Centriole centriole cohesion", "Centriole elongation", "Centromere complex assembly", "Centromeric sister chromatid cohesion", "Centrosome duplication", "Centrosome separation", "Ceramide biosynthetic process", "Ceramide catabolic process", "Ceramide metabolic process", "Ceramide transport", "Cerebellar cortex development", "Cerebellar cortex formation", "Cerebellar cortex morphogenesis", "Cerebellar granular layer development", "Cerebellar granular layer formation", "Cerebellar granular layer morphogenesis", "Cerebellar purkinje cell layer development", "Cerebellar purkinje cell layer formation", "Cerebellar purkinje cell layer morphogenesis", "Cerebral cortex cell migration", "Cerebral cortex development", "Cerebral cortex neuron differentiation", "Cerebral cortex radially oriented cell migration", "Cerebral cortex regionalization", "Cerebral cortex tangential migration", "Cerebrospinal fluid circulation", "Cgmp mediated signaling", "Changes to dna methylation involved in embryo development", "Chaperone cofactor dependent protein refolding", "Chaperone mediated autophagy", "Chaperone mediated protein complex assembly", "Chaperone mediated protein folding", "Chemical homeostasis", "Chemical homeostasis within a tissue", "Chemical synaptic transmission postsynaptic", "Chemokine c c motif ligand 5 production", "Chemokine c x c motif ligand 2 production", "Chemokine production", "Chemosensory behavior", "Chloride transmembrane transport", "Chloride transport", "Cholesterol catabolic process", "Cholesterol efflux", "Cholesterol storage", "Choline metabolic process", "Chondrocyte development", "Chondrocyte development involved in endochondral bone morphogenesis", "Chondrocyte differentiation", "Chondrocyte differentiation involved in endochondral bone morphogenesis", "Chondrocyte proliferation", "Chondroitin sulfate biosynthetic process", "Chondroitin sulfate proteoglycan biosynthetic process", "Chondroitin sulfate proteoglycan metabolic process", "Chromatin assembly or disassembly", "Chromatin disassembly", "Chromatin organization", "Chromatin remodeling", "Chromatin remodeling at centromere", "Chromosome attachment to the nuclear envelope", "Chromosome condensation", "Chromosome localization", "Chromosome movement towards spindle pole", "Chromosome organization", "Chromosome organization involved in meiotic cell cycle", "Chromosome segregation", "Chromosome separation", "Cilium movement", "Cilium or flagellum dependent cell motility", "Cilium organization", "Circadian regulation of gene expression", "Circadian rhythm", "Circulatory system development", "Circulatory system process", "Citrate metabolic process", "Citrulline biosynthetic process", "Citrulline metabolic process", "Clathrin coat assembly", "Clathrin dependent endocytosis", "Cleavage furrow formation", "Cleavage involved in rrna processing", "Cobalamin metabolic process", "Cobalt ion transport", "Cochlea development", "Cochlea morphogenesis", "Coenzyme a biosynthetic process", "Coenzyme a metabolic process", "Cognition", "Cohesin loading", "Collagen biosynthetic process", "Collagen catabolic process", "Collagen fibril organization", "Collagen metabolic process", "Collateral sprouting", "Collateral sprouting in absence of injury", "Collecting duct development", "Columnar cuboidal epithelial cell development", "Columnar cuboidal epithelial cell differentiation", "Columnar cuboidal epithelial cell maturation", "Common partner smad protein phosphorylation", "Complement activation", "Complement dependent cytotoxicity", "Connective tissue development", "Connective tissue replacement", "Constitutive heterochromatin assembly", "Constitutive secretory pathway", "Convergent extension", "Convergent extension involved in axis elongation", "Cop9 signalosome assembly", "Copi coated vesicle budding", "Copii coated vesicle budding", "Copii coated vesicle cargo loading", "Copper ion homeostasis", "Copper ion import", "Copper ion transport", "Coronary artery morphogenesis", "Coronary vasculature development", "Coronary vasculature morphogenesis", "Corpus callosum development", "Corpus callosum morphogenesis", "Cortical actin cytoskeleton organization", "Cortical cytoskeleton organization", "Corticospinal tract morphogenesis", "Corticosteroid receptor signaling pathway", "Cotranslational protein targeting to membrane", "Cranial ganglion development", "Cranial nerve development", "Cranial skeletal system development", "Crd mediated mrna stabilization", "Cristae formation", "Cyclic gmp amp transmembrane import across plasma membrane", "Cyclic nucleotide catabolic process", "Cyclic nucleotide mediated signaling", "Cyclic nucleotide metabolic process", "Cyclooxygenase pathway", "Cysteine metabolic process", "Cytochrome complex assembly", "Cytokine mediated signaling pathway", "Cytokine production", "Cytokine production involved in immune response", "Cytokine production involved in inflammatory response", "Cytokinesis", "Cytokinetic process", "Cytoplasm organization", "Cytoplasmic microtubule organization", "Cytoplasmic pattern recognition receptor signaling pathway", "Cytoplasmic pattern recognition receptor signaling pathway in response to virus", "Cytoplasmic sequestering of nf kappab", "Cytoplasmic sequestering of protein", "Cytoplasmic sequestering of transcription factor", "Cytoplasmic translation", "Cytoplasmic translational elongation", "Cytoplasmic translational initiation", "Cytoskeleton dependent cytokinesis", "Cytoskeleton dependent intracellular transport", "Cytoskeleton organization", "Cytosolic calcium ion transport", "Cytosolic transport", "D amino acid transport", "Damp metabolic process", "De novo amp biosynthetic process", "De novo protein folding", "De novo pyrimidine nucleobase biosynthetic process", "Deadenylation dependent decapping of nuclear transcribed mrna", "Decidualization", "Dedifferentiation", "Defense response", "Defense response to bacterium", "Defense response to fungus", "Defense response to gram negative bacterium", "Defense response to gram positive bacterium", "Defense response to other organism", "Defense response to symbiont", "Defense response to tumor cell", "Definitive erythrocyte differentiation", "Definitive hemopoiesis", "Demethylation", "Dendrite arborization", "Dendrite development", "Dendrite extension", "Dendrite morphogenesis", "Dendrite self avoidance", "Dendritic cell chemotaxis", "Dendritic cell cytokine production", "Dendritic cell differentiation", "Dendritic cell migration", "Dendritic spine development", "Dendritic spine maintenance", "Dendritic spine morphogenesis", "Dendritic transport", "Dense core granule transport", "Dentate gyrus development", "Deoxyribonucleoside catabolic process", "Deoxyribonucleoside diphosphate metabolic process", "Deoxyribonucleoside metabolic process", "Deoxyribonucleoside monophosphate biosynthetic process", "Deoxyribonucleoside monophosphate catabolic process", "Deoxyribonucleoside monophosphate metabolic process", "Deoxyribonucleoside triphosphate biosynthetic process", "Deoxyribonucleoside triphosphate catabolic process", "Deoxyribonucleoside triphosphate metabolic process", "Deoxyribonucleotide biosynthetic process", "Deoxyribose phosphate catabolic process", "Deoxyribose phosphate metabolic process", "Dephosphorylation", "Dephosphorylation of rna polymerase ii c terminal domain", "Depyrimidination", "Dermatan sulfate biosynthetic process", "Dermatan sulfate metabolic process", "Dermatan sulfate proteoglycan metabolic process", "Desmosome organization", "Detection of abiotic stimulus", "Detection of biotic stimulus", "Detection of external biotic stimulus", "Detection of light stimulus", "Detection of mechanical stimulus", "Detection of molecule of bacterial origin", "Detection of muscle stretch", "Detection of other organism", "Detection of stimulus", "Detection of virus", "Detection of visible light", "Determination of adult lifespan", "Determination of dorsal ventral asymmetry", "Detoxification", "Detoxification of copper ion", "Detoxification of nitrogen compound", "Development of primary female sexual characteristics", "Development of primary sexual characteristics", "Development of secondary female sexual characteristics", "Development of secondary sexual characteristics", "Developmental cell growth", "Developmental growth", "Developmental growth involved in morphogenesis", "Developmental induction", "Developmental maturation", "Developmental pigmentation", "Developmental process involved in reproduction", "Diadenosine polyphosphate catabolic process", "Diadenosine polyphosphate metabolic process", "Diapedesis", "Diaphragm development", "Dicarboxylic acid biosynthetic process", "Dicarboxylic acid catabolic process", "Dicarboxylic acid metabolic process", "Dicarboxylic acid transport", "Diencephalon development", "Diet induced thermogenesis", "Digestion", "Digestive system development", "Digestive system process", "Digestive tract morphogenesis", "Diol biosynthetic process", "Diol metabolic process", "Diphosphoinositol polyphosphate metabolic process", "Disaccharide metabolic process", "Diterpenoid biosynthetic process", "Divalent inorganic cation homeostasis", "Dna biosynthetic process", "Dna catabolic process", "Dna catabolic process endonucleolytic", "Dna catabolic process exonucleolytic", "Dna conformation change", "Dna damage response signal transduction by p53 class mediator", "Dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest", "Dna damage response signal transduction resulting in transcription", "Dna dealkylation", "Dna dealkylation involved in dna repair", "Dna deamination", "Dna dependent dna replication", "Dna dependent dna replication maintenance of fidelity", "Dna double strand break processing", "Dna geometric change", "Dna integration", "Dna integrity checkpoint signaling", "Dna ligation", "Dna ligation involved in dna repair", "Dna metabolic process", "Dna methylation", "Dna methylation dependent heterochromatin assembly", "Dna methylation involved in gamete generation", "Dna methylation on cytosine", "Dna methylation or demethylation", "Dna modification", "Dna packaging", "Dna protection", "Dna recombination", "Dna repair", "Dna replication", "Dna replication checkpoint signaling", "Dna replication dependent chromatin organization", "Dna replication independent chromatin organization", "Dna replication initiation", "Dna replication synthesis of rna primer", "Dna strand elongation", "Dna strand elongation involved in dna replication", "Dna synthesis involved in dna repair", "Dna templated transcription elongation", "Dna templated transcription initiation", "Dna templated transcription termination", "Dna topological change", "Dna unwinding involved in dna replication", "Dolichol metabolic process", "Dopamine biosynthetic process", "Dopamine metabolic process", "Dopamine receptor signaling pathway", "Dopamine transport", "Dopaminergic neuron differentiation", "Dorsal root ganglion development", "Dorsal ventral axis specification", "Dorsal ventral neural tube patterning", "Dorsal ventral pattern formation", "Dosage compensation", "Double strand break repair", "Double strand break repair via break induced replication", "Double strand break repair via classical nonhomologous end joining", "Double strand break repair via nonhomologous end joining", "Dsrna processing", "Dtmp metabolic process", "Dttp metabolic process", "Dump metabolic process", "Ear development", "Ear morphogenesis", "Early endosome to golgi transport", "Eating behavior", "Ectoderm development", "Ectodermal placode development", "Ectopic germ cell programmed cell death", "Egg activation", "Electron transport chain", "Embryo development", "Embryo development ending in birth or egg hatching", "Embryo implantation", "Embryonic appendage morphogenesis", "Embryonic axis specification", "Embryonic body morphogenesis", "Embryonic brain development", "Embryonic camera type eye development", "Embryonic cleavage", "Embryonic cranial skeleton morphogenesis", "Embryonic digestive tract development", "Embryonic digestive tract morphogenesis", "Embryonic digit morphogenesis", "Embryonic forelimb morphogenesis", "Embryonic heart tube development", "Embryonic hemopoiesis", "Embryonic hindlimb morphogenesis", "Embryonic morphogenesis", "Embryonic neurocranium morphogenesis", "Embryonic organ development", "Embryonic organ morphogenesis", "Embryonic pattern specification", "Embryonic placenta development", "Embryonic placenta morphogenesis", "Embryonic process involved in female pregnancy", "Embryonic skeletal joint development", "Embryonic skeletal joint morphogenesis", "Embryonic skeletal system development", "Embryonic skeletal system morphogenesis", "Embryonic viscerocranium morphogenesis", "Enamel mineralization", "Endocannabinoid signaling pathway", "Endochondral bone morphogenesis", "Endocrine pancreas development", "Endocrine process", "Endocrine system development", "Endocytic recycling", "Endocytosis", "Endoderm development", "Endoderm formation", "Endodermal cell differentiation", "Endodermal cell fate commitment", "Endomembrane system organization", "Endonucleolytic cleavage in 5 ets of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage in its1 to separate ssu rrna from 5 8s rrna and lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage involved in rrna processing", "Endoplasmic reticulum calcium ion homeostasis", "Endoplasmic reticulum localization", "Endoplasmic reticulum mannose trimming", "Endoplasmic reticulum membrane organization", "Endoplasmic reticulum organization", "Endoplasmic reticulum plasma membrane tethering", "Endoplasmic reticulum to cytosol transport", "Endoplasmic reticulum to golgi vesicle mediated transport", "Endoplasmic reticulum tubular network organization", "Endoplasmic reticulum unfolded protein response", "Endosomal lumen acidification", "Endosomal transport", "Endosome organization", "Endosome to lysosome transport", "Endosome to lysosome transport via multivesicular body sorting pathway", "Endosome to plasma membrane protein transport", "Endosome transport via multivesicular body sorting pathway", "Endothelial cell activation", "Endothelial cell apoptotic process", "Endothelial cell chemotaxis", "Endothelial cell development", "Endothelial cell matrix adhesion", "Endothelial cell migration", "Endothelial cell morphogenesis", "Endothelial cell proliferation", "Endothelin receptor signaling pathway", "Endothelium development", "Energy derivation by oxidation of organic compounds", "Energy homeostasis", "Energy reserve metabolic process", "Engulfment of apoptotic cell", "Ensheathment of neurons", "Enteroendocrine cell differentiation", "Entrainment of circadian clock", "Entry into host", "Entry of bacterium into host cell", "Enzyme directed rrna pseudouridine synthesis", "Enzyme linked receptor protein signaling pathway", "Eosinophil activation", "Eosinophil mediated immunity", "Ephrin receptor signaling pathway", "Epiboly", "Epidermal cell differentiation", "Epidermis development", "Epidermis morphogenesis", "Epigenetic maintenance of chromatin in transcription competent conformation", "Epithelial cell apoptotic process", "Epithelial cell cell adhesion", "Epithelial cell development", "Epithelial cell differentiation", "Epithelial cell differentiation involved in kidney development", "Epithelial cell differentiation involved in prostate gland development", "Epithelial cell maturation", "Epithelial cell morphogenesis", "Epithelial cell proliferation", "Epithelial cell proliferation involved in lung morphogenesis", "Epithelial cell proliferation involved in prostate gland development", "Epithelial fluid transport", "Epithelial structure maintenance", "Epithelial to mesenchymal transition", "Epithelial tube branching involved in lung morphogenesis", "Epithelial tube formation", "Epithelial tube morphogenesis", "Epithelium development", "Epoxide metabolic process", "Er associated misfolded protein catabolic process", "Er nucleus signaling pathway", "Er overload response", "Erad pathway", "Erbb signaling pathway", "Erbb2 signaling pathway", "Erk1 and erk2 cascade", "Error free translesion synthesis", "Erythrocyte development", "Erythrocyte homeostasis", "Erythrocyte maturation", "Escrt complex disassembly", "Establishment of cell polarity", "Establishment of centrosome localization", "Establishment of endothelial barrier", "Establishment of endothelial intestinal barrier", "Establishment of epithelial cell apical basal polarity", "Establishment of epithelial cell polarity", "Establishment of golgi localization", "Establishment of lymphocyte polarity", "Establishment of meiotic spindle localization", "Establishment of mitochondrion localization", "Establishment of mitotic spindle localization", "Establishment of organelle localization", "Establishment of pigment granule localization", "Establishment of planar polarity involved in neural tube closure", "Establishment of planar polarity of embryonic epithelium", "Establishment of protein localization", "Establishment of protein localization to chromatin", "Establishment of protein localization to chromosome", "Establishment of protein localization to endoplasmic reticulum", "Establishment of protein localization to membrane", "Establishment of protein localization to mitochondrial membrane", "Establishment of protein localization to organelle", "Establishment of protein localization to plasma membrane", "Establishment of protein localization to telomere", "Establishment of protein localization to vacuole", "Establishment of rna localization", "Establishment of sister chromatid cohesion", "Establishment of spindle orientation", "Establishment of tissue polarity", "Establishment or maintenance of bipolar cell polarity", "Establishment or maintenance of cell polarity", "Establishment or maintenance of cytoskeleton polarity", "Establishment or maintenance of monopolar cell polarity", "Establishment or maintenance of transmembrane electrochemical gradient", "Estrogen biosynthetic process", "Estrogen metabolic process", "Estrous cycle", "Ethanol catabolic process", "Ethanol metabolic process", "Ethanol oxidation", "Ether biosynthetic process", "Ether metabolic process", "Excitatory synapse assembly", "Excretion", "Execution phase of apoptosis", "Exit from mitosis", "Exocrine pancreas development", "Exocrine system development", "Exocyst localization", "Exocytic process", "Exocytosis", "Exonucleolytic catabolism of deadenylated mrna", "Exploration behavior", "Export across plasma membrane", "Export from cell", "External encapsulating structure organization", "Extracellular exosome assembly", "Extracellular matrix assembly", "Extracellular matrix disassembly", "Extracellular regulation of signal transduction", "Extracellular transport", "Extracellular vesicle biogenesis", "Extrinsic apoptotic signaling pathway", "Extrinsic apoptotic signaling pathway via death domain receptors", "Eye morphogenesis", "Eye photoreceptor cell development", "Eye photoreceptor cell differentiation", "Eyelid development in camera type eye", "Face development", "Facultative heterochromatin assembly", "Farnesyl diphosphate metabolic process", "Fas signaling pathway", "Fat cell differentiation", "Fat cell proliferation", "Fat soluble vitamin metabolic process", "Fatty acid alpha oxidation", "Fatty acid beta oxidation", "Fatty acid beta oxidation using acyl coa dehydrogenase", "Fatty acid beta oxidation using acyl coa oxidase", "Fatty acid biosynthetic process", "Fatty acid catabolic process", "Fatty acid derivative biosynthetic process", "Fatty acid derivative catabolic process", "Fatty acid derivative metabolic process", "Fatty acid elongation", "Fatty acid homeostasis", "Fatty acid metabolic process", "Fatty acid omega oxidation", "Fatty acid transmembrane transport", "Fatty acid transport", "Fatty acyl coa biosynthetic process", "Fatty acyl coa catabolic process", "Fatty acyl coa metabolic process", "Fc gamma receptor signaling pathway", "Fc receptor mediated stimulatory signaling pathway", "Fc receptor signaling pathway", "Fear response", "Feeding behavior", "Female gamete generation", "Female meiosis chromosome segregation", "Female meiosis i", "Female meiotic nuclear division", "Female sex differentiation", "Fermentation", "Fertilization", "Fibroblast activation", "Fibroblast apoptotic process", "Fibroblast growth factor production", "Fibroblast growth factor receptor signaling pathway", "Fibroblast migration", "Fibroblast proliferation", "Filopodium assembly", "Flavin containing compound metabolic process", "Flavonoid metabolic process", "Fluid transport", "Focal adhesion assembly", "Folate import across plasma membrane", "Folate transmembrane transport", "Folic acid containing compound biosynthetic process", "Folic acid containing compound catabolic process", "Folic acid containing compound metabolic process", "Folic acid metabolic process", "Folic acid transport", "Forebrain cell migration", "Forebrain development", "Forebrain dorsal ventral pattern formation", "Forebrain generation of neurons", "Forebrain morphogenesis", "Forebrain neuron development", "Forebrain neuron differentiation", "Forebrain radial glial cell differentiation", "Forebrain regionalization", "Foregut morphogenesis", "Forelimb morphogenesis", "Formate metabolic process", "Formation of extrachromosomal circular dna", "Formation of primary germ layer", "Formation of translation preinitiation complex", "Free ubiquitin chain polymerization", "Fructose 1 6 bisphosphate metabolic process", "Fructose 2 6 bisphosphate metabolic process", "Fructose 6 phosphate metabolic process", "Fructose metabolic process", "Fucose metabolic process", "Fungiform papilla development", "Fungiform papilla morphogenesis", "G protein coupled acetylcholine receptor signaling pathway", "G protein coupled opioid receptor signaling pathway", "G protein coupled purinergic receptor signaling pathway", "G protein coupled receptor internalization", "G protein coupled receptor signaling pathway", "G protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger", "G protein coupled receptor signaling pathway involved in heart process", "G quadruplex dna unwinding", "G0 to g1 transition", "G1 to g0 transition", "Galactose catabolic process", "Galactose metabolic process", "Gamete generation", "Gamma aminobutyric acid metabolic process", "Gamma aminobutyric acid signaling pathway", "Gamma aminobutyric acid transport", "Ganglion development", "Ganglioside catabolic process", "Ganglioside metabolic process", "Gap junction assembly", "Gas homeostasis", "Gastrulation", "Gastrulation with mouth forming second", "Gdp mannose metabolic process", "Gdp metabolic process", "Gene silencing by rna", "Generation of precursor metabolites and energy", "Genitalia development", "Genitalia morphogenesis", "Genomic imprinting", "Germ cell development", "Germ cell migration", "Germ cell proliferation", "Germinal center formation", "Gland development", "Gland morphogenesis", "Glandular epithelial cell development", "Glandular epithelial cell differentiation", "Glial cell apoptotic process", "Glial cell development", "Glial cell differentiation", "Glial cell fate commitment", "Glial cell migration", "Glial cell proliferation", "Gliogenesis", "Glomerular epithelial cell development", "Glomerular epithelial cell differentiation", "Glomerular epithelium development", "Glomerular visceral epithelial cell migration", "Glomerulus development", "Glucan biosynthetic process", "Glucocorticoid biosynthetic process", "Glucocorticoid metabolic process", "Glucosamine containing compound catabolic process", "Glucosamine containing compound metabolic process", "Glucose 6 phosphate metabolic process", "Glucose catabolic process", "Glucose import", "Glucose import in response to insulin stimulus", "Glucose metabolic process", "Glucosylceramide metabolic process", "Glutamate biosynthetic process", "Glutamate catabolic process", "Glutamate homeostasis", "Glutamate metabolic process", "Glutamate receptor signaling pathway", "Glutamate reuptake", "Glutamate secretion", "Glutamate secretion neurotransmission", "Glutamine family amino acid biosynthetic process", "Glutamine family amino acid catabolic process", "Glutamine family amino acid metabolic process", "Glutamine metabolic process", "Glutamine transport", "Glutathione metabolic process", "Glycerol 3 phosphate metabolic process", "Glycerol ether metabolic process", "Glycerolipid biosynthetic process", "Glycerolipid catabolic process", "Glycerolipid metabolic process", "Glycerophospholipid biosynthetic process", "Glycerophospholipid catabolic process", "Glycerophospholipid metabolic process", "Glycine biosynthetic process", "Glycine metabolic process", "Glycolipid biosynthetic process", "Glycolipid catabolic process", "Glycolipid transport", "Glycolytic fermentation", "Glycolytic process through fructose 6 phosphate", "Glycoprotein biosynthetic process", "Glycoprotein catabolic process", "Glycoprotein metabolic process", "Glycosaminoglycan catabolic process", "Glycoside catabolic process", "Glycoside metabolic process", "Glycosphingolipid metabolic process", "Glycosyl compound biosynthetic process", "Glycosyl compound catabolic process", "Glycosyl compound metabolic process", "Glycosylation", "Glycosylceramide catabolic process", "Glycosylceramide metabolic process", "Glyoxylate metabolic process", "Gmp biosynthetic process", "Gmp metabolic process", "Gmp salvage", "Golgi disassembly", "Golgi localization", "Golgi organization", "Golgi ribbon formation", "Golgi to endosome transport", "Golgi to lysosome transport", "Golgi to plasma membrane protein transport", "Golgi to plasma membrane transport", "Golgi to vacuole transport", "Golgi vesicle budding", "Golgi vesicle transport", "Gpi anchor metabolic process", "Granulocyte activation", "Granulocyte chemotaxis", "Granulocyte differentiation", "Granulocyte migration", "Granzyme mediated programmed cell death signaling pathway", "Grooming behavior", "Growth", "Growth hormone receptor signaling pathway via jak stat", "Growth hormone secretion", "Growth plate cartilage chondrocyte differentiation", "Growth plate cartilage development", "Gtp biosynthetic process", "Gtp metabolic process", "Guanine metabolic process", "Guanine nucleotide transmembrane transport", "Guanine nucleotide transport", "Hair cell differentiation", "Hair cycle phase", "Hair follicle maturation", "Hair follicle placode formation", "Head development", "Head morphogenesis", "Heart development", "Heart formation", "Heart growth", "Heart morphogenesis", "Heart process", "Heart valve development", "Heart valve morphogenesis", "Heat acclimation", "Hematopoietic progenitor cell differentiation", "Hematopoietic stem cell differentiation", "Hematopoietic stem cell homeostasis", "Hematopoietic stem cell proliferation", "Heme transport", "Hemidesmosome assembly", "Hemoglobin biosynthetic process", "Hemoglobin metabolic process", "Hemostasis", "Heparan sulfate proteoglycan biosynthetic process", "Heparan sulfate proteoglycan metabolic process", "Hepatic stellate cell activation", "Hepaticobiliary system development", "Hepatocyte differentiation", "Hepatocyte growth factor receptor signaling pathway", "Heterochromatin organization", "Heterotypic cell cell adhesion", "High density lipoprotein particle assembly", "High density lipoprotein particle clearance", "High density lipoprotein particle remodeling", "Hindbrain development", "Hindbrain maturation", "Hindbrain morphogenesis", "Hindbrain radial glia guided cell migration", "Hindlimb morphogenesis", "Hippo signaling", "Hippocampus development", "His purkinje system development", "Histamine production involved in inflammatory response", "Histamine secretion", "Histamine transport", "Histidine metabolic process", "Histone arginine methylation", "Histone deacetylation", "Histone deubiquitination", "Histone exchange", "Histone h2a acetylation", "Histone h2a k63 linked ubiquitination", "Histone h2a monoubiquitination", "Histone h2a phosphorylation", "Histone h2a ubiquitination", "Histone h2b ubiquitination", "Histone h3 acetylation", "Histone h3 deacetylation", "Histone h3 k14 acetylation", "Histone h3 k27 methylation", "Histone h3 k27 trimethylation", "Histone h3 k36 demethylation", "Histone h3 k36 methylation", "Histone h3 k4 demethylation", "Histone h3 k4 dimethylation", "Histone h3 k4 methylation", "Histone h3 k4 monomethylation", "Histone h3 k4 trimethylation", "Histone h3 k9 acetylation", "Histone h3 k9 demethylation", "Histone h3 k9 dimethylation", "Histone h3 k9 methylation", "Histone h3 k9 modification", "Histone h3 k9 trimethylation", "Histone h4 acetylation", "Histone h4 deacetylation", "Histone h4 k16 acetylation", "Histone h4 k20 methylation", "Histone h4 k20 trimethylation", "Histone h4 k5 acetylation", "Histone h4 r3 methylation", "Histone lysine demethylation", "Histone methylation", "Histone modification", "Histone monoubiquitination", "Histone mrna catabolic process", "Histone mrna metabolic process", "Histone phosphorylation", "Histone serine phosphorylation", "Histone threonine phosphorylation", "Histone ubiquitination", "Homeostasis of number of cells", "Homeostasis of number of cells within a tissue", "Homeostatic process", "Homocysteine metabolic process", "Homologous chromosome pairing at meiosis", "Homologous chromosome segregation", "Homologous recombination", "Homophilic cell adhesion via plasma membrane adhesion molecules", "Homotypic cell cell adhesion", "Hormone biosynthetic process", "Hormone catabolic process", "Hormone mediated signaling pathway", "Hormone metabolic process", "Hormone transport", "Humoral immune response", "Humoral immune response mediated by circulating immunoglobulin", "Hyaluronan biosynthetic process", "Hyaluronan metabolic process", "Hydrogen peroxide biosynthetic process", "Hydrogen peroxide catabolic process", "Hydrogen peroxide metabolic process", "Hydrogen sulfide biosynthetic process", "Hydrogen sulfide metabolic process", "Hyperosmotic response", "Hyperosmotic salinity response", "Hypothalamus cell differentiation", "Hypothalamus development", "Hypoxia inducible factor 1alpha signaling pathway", "I kappab kinase nf kappab signaling", "I kappab phosphorylation", "Icosanoid biosynthetic process", "Icosanoid metabolic process", "Icosanoid transport", "Immune effector process", "Immune response", "Immune response regulating cell surface receptor signaling pathway", "Immune response regulating signaling pathway", "Immune response to tumor cell", "Immune system development", "Immunoglobulin production", "Immunoglobulin production involved in immunoglobulin mediated immune response", "Immunoglobulin v d j recombination", "Immunological synapse formation", "Imp biosynthetic process", "Imp catabolic process", "Imp metabolic process", "Imp salvage", "Import across plasma membrane", "Import into cell", "Import into nucleus", "In utero embryonic development", "Inclusion body assembly", "Indolalkylamine metabolic process", "Indole containing compound biosynthetic process", "Indole containing compound metabolic process", "Inflammasome complex assembly", "Inflammatory cell apoptotic process", "Inflammatory response", "Inflammatory response to antigenic stimulus", "Inflammatory response to wounding", "Innate immune response", "Innate immune response activating signal transduction", "Innate immune response in mucosa", "Inner cell mass cell differentiation", "Inner cell mass cell proliferation", "Inner dynein arm assembly", "Inner ear auditory receptor cell differentiation", "Inner ear morphogenesis", "Inner ear receptor cell development", "Inner ear receptor cell stereocilium organization", "Inner mitochondrial membrane organization", "Innervation", "Inorganic anion transmembrane transport", "Inorganic anion transport", "Inorganic ion import across plasma membrane", "Inorganic ion transmembrane transport", "Inosine metabolic process", "Inositol lipid mediated signaling", "Inositol metabolic process", "Inositol phosphate catabolic process", "Inositol phosphate mediated signaling", "Inositol phosphate metabolic process", "Insulin like growth factor receptor signaling pathway", "Insulin metabolic process", "Insulin processing", "Insulin receptor signaling pathway", "Insulin secretion", "Insulin secretion involved in cellular response to glucose stimulus", "Integrated stress response signaling", "Integrin activation", "Integrin mediated signaling pathway", "Interferon alpha production", "Interferon beta production", "Interferon gamma mediated signaling pathway", "Interferon gamma production", "Interleukin 1 mediated signaling pathway", "Interleukin 1 production", "Interleukin 10 production", "Interleukin 12 production", "Interleukin 13 production", "Interleukin 17 production", "Interleukin 18 production", "Interleukin 2 production", "Interleukin 23 production", "Interleukin 6 mediated signaling pathway", "Interleukin 6 production", "Interleukin 8 production", "Intermediate filament based process", "Intermediate filament bundle assembly", "Intermediate filament organization", "Intermembrane lipid transfer", "Interstrand cross link repair", "Intestinal absorption", "Intestinal epithelial cell development", "Intestinal epithelial cell differentiation", "Intestinal hexose absorption", "Intestinal lipid absorption", "Intra golgi vesicle mediated transport", "Intracellular distribution of mitochondria", "Intracellular estrogen receptor signaling pathway", "Intracellular lipid transport", "Intracellular mrna localization", "Intracellular protein transmembrane transport", "Intracellular protein transport", "Intracellular receptor signaling pathway", "Intracellular sterol transport", "Intracellular transport", "Intracellular transport of virus", "Intraciliary retrograde transport", "Intraciliary transport", "Intraciliary transport involved in cilium assembly", "Intrinsic apoptotic signaling pathway", "Intrinsic apoptotic signaling pathway by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to dna damage", "Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "Intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "Intrinsic apoptotic signaling pathway in response to hypoxia", "Intrinsic apoptotic signaling pathway in response to osmotic stress", "Intrinsic apoptotic signaling pathway in response to oxidative stress", "Ion homeostasis", "Ion transmembrane transport", "Ion transport", "Ire1 mediated unfolded protein response", "Ires dependent viral translational initiation", "Iron coordination entity transport", "Iron ion homeostasis", "Iron ion transmembrane transport", "Iron ion transport", "Iron sulfur cluster assembly", "Isocitrate metabolic process", "Isoleucine metabolic process", "Isopentenyl diphosphate biosynthetic process", "Isoprenoid biosynthetic process", "Isoprenoid metabolic process", "Isotype switching to iga isotypes", "Isotype switching to igg isotypes", "Jnk cascade", "Keratan sulfate metabolic process", "Keratinization", "Keratinocyte development", "Keratinocyte differentiation", "Keratinocyte migration", "Keratinocyte proliferation", "Ketone biosynthetic process", "Ketone body biosynthetic process", "Ketone body metabolic process", "Ketone catabolic process", "Kidney epithelium development", "Kidney mesenchyme development", "Kidney morphogenesis", "Killing by host of symbiont cells", "Killing of cells of another organism", "Kinetochore assembly", "Kinetochore organization", "Kynurenine metabolic process", "L alanine transport", "L alpha amino acid transmembrane transport", "L amino acid transport", "L ascorbic acid metabolic process", "L aspartate transmembrane transport", "L glutamate import across plasma membrane", "L glutamate transmembrane transport", "L kynurenine metabolic process", "L methionine salvage from methylthioadenosine", "L phenylalanine metabolic process", "L proline biosynthetic process", "L serine biosynthetic process", "L serine catabolic process", "L serine metabolic process", "L serine transport", "Labyrinthine layer blood vessel development", "Labyrinthine layer development", "Labyrinthine layer morphogenesis", "Lacrimal gland development", "Lactate metabolic process", "Lactate transmembrane transport", "Lactation", "Lamellipodium assembly", "Lamellipodium morphogenesis", "Lamellipodium organization", "Late endosome to golgi transport", "Late endosome to lysosome transport", "Late endosome to vacuole transport", "Late endosome to vacuole transport via multivesicular body sorting pathway", "Lateral ventricle development", "Layer formation in cerebral cortex", "Learned vocalization behavior or vocal learning", "Learning", "Lens development in camera type eye", "Lens fiber cell development", "Lens fiber cell differentiation", "Lens morphogenesis in camera type eye", "Leptin mediated signaling pathway", "Leucine catabolic process", "Leucine import across plasma membrane", "Leucine metabolic process", "Leucine transport", "Leukocyte adhesion to vascular endothelial cell", "Leukocyte aggregation", "Leukocyte apoptotic process", "Leukocyte cell cell adhesion", "Leukocyte chemotaxis", "Leukocyte degranulation", "Leukocyte differentiation", "Leukocyte homeostasis", "Leukocyte mediated cytotoxicity", "Leukocyte mediated immunity", "Leukocyte migration", "Leukocyte proliferation", "Leukocyte tethering or rolling", "Leukotriene b4 metabolic process", "Leukotriene biosynthetic process", "Leukotriene metabolic process", "Leukotriene transport", "Leydig cell differentiation", "Ligand gated ion channel signaling pathway", "Limb joint morphogenesis", "Limbic system development", "Linoleic acid metabolic process", "Lipid biosynthetic process", "Lipid catabolic process", "Lipid digestion", "Lipid droplet formation", "Lipid droplet organization", "Lipid export from cell", "Lipid glycosylation", "Lipid homeostasis", "Lipid import into cell", "Lipid localization", "Lipid metabolic process", "Lipid modification", "Lipid oxidation", "Lipid phosphorylation", "Lipid storage", "Lipid translocation", "Lipid transport across blood brain barrier", "Lipophagy", "Lipopolysaccharide mediated signaling pathway", "Lipoprotein biosynthetic process", "Lipoprotein catabolic process", "Lipoprotein localization", "Lipoprotein metabolic process", "Liposaccharide metabolic process", "Lipoxin metabolic process", "Liver morphogenesis", "Liver regeneration", "Localization within membrane", "Locomotion", "Locomotion involved in locomotory behavior", "Locomotor rhythm", "Locomotory behavior", "Locomotory exploration behavior", "Long chain fatty acid biosynthetic process", "Long chain fatty acid import across plasma membrane", "Long chain fatty acid metabolic process", "Long chain fatty acid transport", "Long chain fatty acyl coa biosynthetic process", "Long chain fatty acyl coa metabolic process", "Long term memory", "Long term synaptic depression", "Long term synaptic potentiation", "Low density lipoprotein particle clearance", "Low density lipoprotein receptor particle metabolic process", "Lung alveolus development", "Lung associated mesenchyme development", "Lung cell differentiation", "Lung epithelium development", "Lung lobe development", "Lung morphogenesis", "Lung saccule development", "Lung secretory cell differentiation", "Luteinization", "Luteolysis", "Lymph vessel development", "Lymph vessel morphogenesis", "Lymphangiogenesis", "Lymphocyte activation", "Lymphocyte activation involved in immune response", "Lymphocyte aggregation", "Lymphocyte anergy", "Lymphocyte apoptotic process", "Lymphocyte chemotaxis", "Lymphocyte costimulation", "Lymphocyte homeostasis", "Lymphocyte mediated immunity", "Lymphocyte migration", "Lymphoid progenitor cell differentiation", "Lysine catabolic process", "Lysine metabolic process", "Lysosomal lumen acidification", "Lysosomal membrane organization", "Lysosomal microautophagy", "Lysosomal protein catabolic process", "Lysosomal transport", "Lytic vacuole organization", "Macroautophagy", "Macromolecule catabolic process", "Macromolecule deacylation", "Macromolecule depalmitoylation", "Macrophage activation", "Macrophage apoptotic process", "Macrophage chemotaxis", "Macrophage differentiation", "Macrophage inflammatory protein 1 alpha production", "Macrophage migration", "Macrophage proliferation", "Macropinocytosis", "Magnesium ion homeostasis", "Magnesium ion transport", "Maintenance of apical basal cell polarity", "Maintenance of blood brain barrier", "Maintenance of cell number", "Maintenance of cell polarity", "Maintenance of centrosome location", "Maintenance of dna methylation", "Maintenance of dna repeat elements", "Maintenance of gastrointestinal epithelium", "Maintenance of lens transparency", "Maintenance of location", "Maintenance of location in cell", "Maintenance of organelle location", "Maintenance of postsynaptic specialization structure", "Maintenance of presynaptic active zone structure", "Maintenance of protein localization in endoplasmic reticulum", "Maintenance of protein localization in organelle", "Maintenance of protein location", "Maintenance of protein location in cell", "Maintenance of protein location in mitochondrion", "Maintenance of protein location in nucleus", "Maintenance of sister chromatid cohesion", "Maintenance of synapse structure", "Malate metabolic process", "Male gamete generation", "Male genitalia development", "Male mating behavior", "Male meiosis i", "Male meiotic nuclear division", "Male sex determination", "Male sex differentiation", "Malonyl coa metabolic process", "Mammalian oogenesis stage", "Mammary gland alveolus development", "Mammary gland development", "Mammary gland duct morphogenesis", "Mammary gland epithelial cell differentiation", "Mammary gland epithelial cell proliferation", "Mammary gland epithelium development", "Mammary gland involution", "Mammary gland morphogenesis", "Manganese ion transmembrane transport", "Manganese ion transport", "Mannose metabolic process", "Mannosylation", "Mapk cascade", "Mast cell activation", "Mast cell activation involved in immune response", "Mast cell cytokine production", "Maternal placenta development", "Maternal process involved in female pregnancy", "Mating", "Mating behavior", "Maturation of 5 8s rrna", "Maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of lsu rrna", "Maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of ssu rrna", "Maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Mature ribosome assembly", "Mda 5 signaling pathway", "Mechanoreceptor differentiation", "Mechanosensory behavior", "Medium chain fatty acid biosynthetic process", "Medium chain fatty acid catabolic process", "Medium chain fatty acid metabolic process", "Medium chain fatty acyl coa metabolic process", "Megakaryocyte differentiation", "Meiosis i cell cycle process", "Meiosis ii cell cycle process", "Meiotic cell cycle", "Meiotic cell cycle checkpoint signaling", "Meiotic cell cycle phase transition", "Meiotic cell cycle process", "Meiotic chromosome condensation", "Meiotic chromosome segregation", "Meiotic chromosome separation", "Meiotic cytokinesis", "Meiotic dna double strand break formation", "Meiotic sister chromatid cohesion centromeric", "Meiotic spindle organization", "Melanocyte differentiation", "Membrane biogenesis", "Membrane depolarization", "Membrane depolarization during action potential", "Membrane depolarization during cardiac muscle cell action potential", "Membrane disassembly", "Membrane docking", "Membrane fission", "Membrane fusion", "Membrane fusion involved in viral entry into host cell", "Membrane hyperpolarization", "Membrane invagination", "Membrane lipid biosynthetic process", "Membrane lipid catabolic process", "Membrane lipid metabolic process", "Membrane organization", "Membrane protein ectodomain proteolysis", "Membrane protein intracellular domain proteolysis", "Membrane protein proteolysis", "Membrane raft assembly", "Membrane raft localization", "Membrane raft organization", "Membrane repolarization", "Membrane repolarization during action potential", "Membrane repolarization during atrial cardiac muscle cell action potential", "Membrane repolarization during cardiac muscle cell action potential", "Membrane to membrane docking", "Membranous septum morphogenesis", "Memory", "Mesenchymal cell development", "Mesenchymal cell differentiation", "Mesenchymal cell proliferation", "Mesenchymal cell proliferation involved in lung development", "Mesenchymal stem cell differentiation", "Mesenchymal stem cell proliferation", "Mesenchymal to epithelial transition", "Mesenchymal to epithelial transition involved in metanephros morphogenesis", "Mesenchyme development", "Mesenchyme morphogenesis", "Mesoderm development", "Mesoderm morphogenesis", "Mesodermal cell differentiation", "Mesonephric tubule morphogenesis", "Mesonephros development", "Metal ion export", "Metal ion homeostasis", "Metal ion transport", "Metanephric collecting duct development", "Metanephric epithelium development", "Metanephric mesenchyme development", "Metanephric nephron development", "Metanephric nephron morphogenesis", "Metanephric part of ureteric bud development", "Metanephric renal vesicle morphogenesis", "Metanephric tubule development", "Metanephros development", "Metanephros morphogenesis", "Metaphase anaphase transition of cell cycle", "Metaphase plate congression", "Metencephalon development", "Methionine biosynthetic process", "Methionine metabolic process", "Methylation", "Methylglyoxal metabolic process", "Methylguanosine cap decapping", "Mhc class i biosynthetic process", "Mhc class ii biosynthetic process", "Microglia differentiation", "Microglial cell activation", "Microglial cell proliferation", "Microtubule anchoring", "Microtubule anchoring at centrosome", "Microtubule anchoring at microtubule organizing center", "Microtubule based movement", "Microtubule based process", "Microtubule based transport", "Microtubule bundle formation", "Microtubule cytoskeleton organization", "Microtubule cytoskeleton organization involved in mitosis", "Microtubule depolymerization", "Microtubule nucleation", "Microtubule organizing center localization", "Microtubule organizing center organization", "Microtubule polymerization", "Microtubule polymerization or depolymerization", "Microvillus assembly", "Microvillus organization", "Midbody abscission", "Midbrain development", "Midbrain dopaminergic neuron differentiation", "Middle ear morphogenesis", "Midgut development", "Minus end directed organelle transport along microtubule", "Mirna catabolic process", "Mirna loading onto risc involved in gene silencing by mirna", "Mirna metabolic process", "Mismatch repair", "Mitochondrial acetyl coa biosynthetic process from pyruvate", "Mitochondrial adp transmembrane transport", "Mitochondrial atp synthesis coupled proton transport", "Mitochondrial calcium ion homeostasis", "Mitochondrial calcium ion transmembrane transport", "Mitochondrial cytochrome c oxidase assembly", "Mitochondrial depolarization", "Mitochondrial dna metabolic process", "Mitochondrial dna repair", "Mitochondrial dna replication", "Mitochondrial electron transport cytochrome c to oxygen", "Mitochondrial electron transport nadh to ubiquinone", "Mitochondrial electron transport ubiquinol to cytochrome c", "Mitochondrial fission", "Mitochondrial fragmentation involved in apoptotic process", "Mitochondrial fusion", "Mitochondrial gene expression", "Mitochondrial genome maintenance", "Mitochondrial membrane organization", "Mitochondrial outer membrane permeabilization", "Mitochondrial outer membrane permeabilization involved in programmed cell death", "Mitochondrial protein catabolic process", "Mitochondrial protein processing", "Mitochondrial respirasome assembly", "Mitochondrial respiratory chain complex assembly", "Mitochondrial ribosome assembly", "Mitochondrial rna 3 end processing", "Mitochondrial rna catabolic process", "Mitochondrial rna metabolic process", "Mitochondrial rna modification", "Mitochondrial rna processing", "Mitochondrial transcription", "Mitochondrial translation", "Mitochondrial translational elongation", "Mitochondrial transmembrane transport", "Mitochondrial transport", "Mitochondrial trna processing", "Mitochondrion distribution", "Mitochondrion endoplasmic reticulum membrane tethering", "Mitochondrion localization", "Mitochondrion morphogenesis", "Mitochondrion organization", "Mitophagy", "Mitotic cell cycle", "Mitotic cell cycle checkpoint signaling", "Mitotic cell cycle phase transition", "Mitotic cell cycle process", "Mitotic chromosome condensation", "Mitotic cytokinesis", "Mitotic cytokinetic process", "Mitotic dna integrity checkpoint signaling", "Mitotic dna replication", "Mitotic dna replication checkpoint signaling", "Mitotic g1 s transition checkpoint signaling", "Mitotic g2 dna damage checkpoint signaling", "Mitotic g2 m transition checkpoint", "Mitotic intra s dna damage checkpoint signaling", "Mitotic metaphase plate congression", "Mitotic nuclear division", "Mitotic nuclear membrane disassembly", "Mitotic nuclear membrane organization", "Mitotic recombination", "Mitotic sister chromatid cohesion", "Mitotic sister chromatid segregation", "Mitotic spindle assembly", "Mitotic spindle midzone assembly", "Mitotic spindle organization", "Modification dependent macromolecule catabolic process", "Modification of postsynaptic actin cytoskeleton", "Modification of postsynaptic structure", "Modification of synaptic structure", "Modified amino acid transport", "Modulation by host of symbiont catalytic activity", "Modulation by host of symbiont process", "Modulation by host of viral genome replication", "Modulation by host of viral process", "Modulation of age related behavioral decline", "Modulation of excitatory postsynaptic potential", "Molting cycle", "Monoacylglycerol catabolic process", "Monoacylglycerol metabolic process", "Monoamine transport", "Monocarboxylic acid biosynthetic process", "Monocarboxylic acid catabolic process", "Monocarboxylic acid metabolic process", "Monocarboxylic acid transport", "Monocyte chemotaxis", "Monocyte differentiation", "Mononuclear cell differentiation", "Mononuclear cell migration", "Monosaccharide biosynthetic process", "Monosaccharide catabolic process", "Monosaccharide metabolic process", "Monoubiquitinated protein deubiquitination", "Monovalent inorganic anion homeostasis", "Monovalent inorganic cation homeostasis", "Morphogenesis of a branching structure", "Morphogenesis of a polarized epithelium", "Morphogenesis of an endothelium", "Morphogenesis of an epithelial bud", "Morphogenesis of an epithelial fold", "Morphogenesis of an epithelial sheet", "Morphogenesis of an epithelium", "Morphogenesis of embryonic epithelium", "Motor behavior", "Motor learning", "Motor neuron apoptotic process", "Motor neuron axon guidance", "Mrna 3 end processing", "Mrna 3 end processing by stem loop binding and cleavage", "Mrna 3 splice site recognition", "Mrna 5 splice site recognition", "Mrna alternative polyadenylation", "Mrna catabolic process", "Mrna cis splicing via spliceosome", "Mrna cleavage", "Mrna cleavage involved in mrna processing", "Mrna destabilization mediated gene silencing", "Mrna export from nucleus", "Mrna metabolic process", "Mrna methylation", "Mrna modification", "Mrna processing", "Mrna pseudouridine synthesis", "Mrna splice site selection", "Mrna transcription", "Mrna transport", "Mucopolysaccharide metabolic process", "Multi multicellular organism process", "Multi organism reproductive process", "Multicellular organism aging", "Multicellular organism growth", "Multicellular organism reproduction", "Multicellular organismal homeostasis", "Multicellular organismal movement", "Multicellular organismal response to stress", "Multicellular organismal signaling", "Multivesicular body organization", "Multivesicular body sorting pathway", "Muscle adaptation", "Muscle cell apoptotic process", "Muscle cell cellular homeostasis", "Muscle cell development", "Muscle cell differentiation", "Muscle cell migration", "Muscle cell proliferation", "Muscle contraction", "Muscle hypertrophy", "Muscle hypertrophy in response to stress", "Muscle organ development", "Muscle organ morphogenesis", "Muscle structure development", "Muscle system process", "Muscle tissue development", "Myd88 dependent toll like receptor signaling pathway", "Myelin assembly", "Myelin maintenance", "Myeloid cell activation involved in immune response", "Myeloid cell apoptotic process", "Myeloid cell development", "Myeloid cell differentiation", "Myeloid cell homeostasis", "Myeloid dendritic cell activation", "Myeloid dendritic cell cytokine production", "Myeloid leukocyte activation", "Myeloid leukocyte cytokine production", "Myeloid leukocyte differentiation", "Myeloid leukocyte mediated immunity", "Myeloid leukocyte migration", "Myeloid progenitor cell differentiation", "Myoblast differentiation", "Myoblast fusion", "Myoblast migration", "Myofibroblast differentiation", "Myotube cell development", "Myotube differentiation", "N acetylglucosamine metabolic process", "N acetylneuraminate catabolic process", "N acetylneuraminate metabolic process", "N glycan processing", "N terminal peptidyl methionine acetylation", "N terminal protein amino acid acetylation", "N terminal protein amino acid modification", "N terminal protein lipidation", "Nad biosynthesis via nicotinamide riboside salvage pathway", "Nad metabolic process", "Nadh dehydrogenase complex assembly", "Nadh metabolic process", "Nadh oxidation", "Nadh regeneration", "Nadp metabolic process", "Nadph regeneration", "Natural killer cell activation", "Natural killer cell activation involved in immune response", "Natural killer cell degranulation", "Natural killer cell differentiation", "Natural killer cell mediated immune response to tumor cell", "Natural killer cell mediated immunity", "Ncrna 3 end processing", "Ncrna catabolic process", "Ncrna export from nucleus", "Ncrna metabolic process", "Ncrna processing", "Ncrna transcription", "Necroptotic signaling pathway", "Necrotic cell death", "Negative chemotaxis", "Negative regulation by host of viral genome replication", "Negative regulation by host of viral process", "Negative regulation by host of viral transcription", "Negative regulation of actin filament bundle assembly", "Negative regulation of actin filament depolymerization", "Negative regulation of actin filament polymerization", "Negative regulation of actin nucleation", "Negative regulation of activated t cell proliferation", "Negative regulation of activin receptor signaling pathway", "Negative regulation of adaptive immune response", "Negative regulation of adenylate cyclase activating adrenergic receptor signaling pathway", "Negative regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Negative regulation of adenylate cyclase activity", "Negative regulation of alcohol biosynthetic process", "Negative regulation of alpha beta t cell activation", "Negative regulation of alpha beta t cell differentiation", "Negative regulation of alpha beta t cell proliferation", "Negative regulation of amine transport", "Negative regulation of amino acid transport", "Negative regulation of amyloid beta clearance", "Negative regulation of amyloid fibril formation", "Negative regulation of amyloid precursor protein biosynthetic process", "Negative regulation of amyloid precursor protein catabolic process", "Negative regulation of androgen receptor signaling pathway", "Negative regulation of anion transmembrane transport", "Negative regulation of anion transport", "Negative regulation of anoikis", "Negative regulation of antigen receptor mediated signaling pathway", "Negative regulation of apoptotic process involved in development", "Negative regulation of apoptotic signaling pathway", "Negative regulation of arp2 3 complex mediated actin nucleation", "Negative regulation of atp biosynthetic process", "Negative regulation of atp dependent activity", "Negative regulation of atp metabolic process", "Negative regulation of autophagosome assembly", "Negative regulation of autophagosome maturation", "Negative regulation of autophagy", "Negative regulation of autophagy of mitochondrion", "Negative regulation of axon extension", "Negative regulation of axonogenesis", "Negative regulation of b cell activation", "Negative regulation of b cell apoptotic process", "Negative regulation of b cell differentiation", "Negative regulation of b cell mediated immunity", "Negative regulation of behavior", "Negative regulation of bicellular tight junction assembly", "Negative regulation of binding", "Negative regulation of biomineralization", "Negative regulation of biosynthetic process", "Negative regulation of blood circulation", "Negative regulation of blood pressure", "Negative regulation of blood vessel endothelial cell migration", "Negative regulation of bmp signaling pathway", "Negative regulation of bone remodeling", "Negative regulation of calcineurin mediated signaling", "Negative regulation of calcium ion dependent exocytosis", "Negative regulation of calcium ion import", "Negative regulation of calcium ion transmembrane transport", "Negative regulation of calcium ion transport", "Negative regulation of calcium ion transport into cytosol", "Negative regulation of calcium mediated signaling", "Negative regulation of camp dependent protein kinase activity", "Negative regulation of camp mediated signaling", "Negative regulation of canonical wnt signaling pathway", "Negative regulation of carbohydrate metabolic process", "Negative regulation of cardiac muscle adaptation", "Negative regulation of cardiac muscle contraction", "Negative regulation of cardiac muscle tissue growth", "Negative regulation of cartilage development", "Negative regulation of catabolic process", "Negative regulation of catalytic activity", "Negative regulation of cation channel activity", "Negative regulation of cd4 positive alpha beta t cell activation", "Negative regulation of cd4 positive alpha beta t cell differentiation", "Negative regulation of cd4 positive alpha beta t cell proliferation", "Negative regulation of cell activation", "Negative regulation of cell adhesion", "Negative regulation of cell aging", "Negative regulation of cell cell adhesion", "Negative regulation of cell cycle", "Negative regulation of cell cycle checkpoint", "Negative regulation of cell cycle g1 s phase transition", "Negative regulation of cell cycle g2 m phase transition", "Negative regulation of cell cycle phase transition", "Negative regulation of cell cycle process", "Negative regulation of cell death", "Negative regulation of cell development", "Negative regulation of cell differentiation", "Negative regulation of cell division", "Negative regulation of cell growth", "Negative regulation of cell growth involved in cardiac muscle cell development", "Negative regulation of cell junction assembly", "Negative regulation of cell killing", "Negative regulation of cell matrix adhesion", "Negative regulation of cell migration involved in sprouting angiogenesis", "Negative regulation of cell morphogenesis involved in differentiation", "Negative regulation of cell population proliferation", "Negative regulation of cell projection organization", "Negative regulation of cell size", "Negative regulation of cell substrate adhesion", "Negative regulation of cell substrate junction organization", "Negative regulation of cell volume", "Negative regulation of cellular amide metabolic process", "Negative regulation of cellular amine metabolic process", "Negative regulation of cellular catabolic process", "Negative regulation of cellular component organization", "Negative regulation of cellular macromolecule biosynthetic process", "Negative regulation of cellular protein catabolic process", "Negative regulation of cellular respiration", "Negative regulation of cellular response to growth factor stimulus", "Negative regulation of cellular response to hypoxia", "Negative regulation of cellular response to insulin stimulus", "Negative regulation of cellular response to vascular endothelial growth factor stimulus", "Negative regulation of cellular senescence", "Negative regulation of centriole replication", "Negative regulation of centrosome duplication", "Negative regulation of chemokine c c motif ligand 5 production", "Negative regulation of chemokine mediated signaling pathway", "Negative regulation of chemokine production", "Negative regulation of chemotaxis", "Negative regulation of cholesterol metabolic process", "Negative regulation of chondrocyte differentiation", "Negative regulation of chromatin binding", "Negative regulation of chromosome organization", "Negative regulation of cilium assembly", "Negative regulation of circadian rhythm", "Negative regulation of cold induced thermogenesis", "Negative regulation of collateral sprouting", "Negative regulation of cyclic nucleotide phosphodiesterase activity", "Negative regulation of cyclin dependent protein serine threonine kinase activity", "Negative regulation of cysteine type endopeptidase activity", "Negative regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Negative regulation of cytokine production", "Negative regulation of cytokine production involved in immune response", "Negative regulation of cytokine production involved in inflammatory response", "Negative regulation of cytoplasmic translation", "Negative regulation of cytoskeleton organization", "Negative regulation of cytosolic calcium ion concentration", "Negative regulation of defense response", "Negative regulation of defense response to bacterium", "Negative regulation of defense response to virus", "Negative regulation of delayed rectifier potassium channel activity", "Negative regulation of dendrite development", "Negative regulation of dendrite morphogenesis", "Negative regulation of dendritic spine development", "Negative regulation of dephosphorylation", "Negative regulation of developmental growth", "Negative regulation of developmental process", "Negative regulation of dna binding", "Negative regulation of dna binding transcription factor activity", "Negative regulation of dna biosynthetic process", "Negative regulation of dna damage checkpoint", "Negative regulation of dna damage response signal transduction by p53 class mediator", "Negative regulation of dna dependent dna replication", "Negative regulation of dna metabolic process", "Negative regulation of dna recombination", "Negative regulation of dna repair", "Negative regulation of dna replication", "Negative regulation of dna templated transcription elongation", "Negative regulation of dna templated transcription initiation", "Negative regulation of double strand break repair via homologous recombination", "Negative regulation of double strand break repair via nonhomologous end joining", "Negative regulation of endocytosis", "Negative regulation of endoplasmic reticulum calcium ion concentration", "Negative regulation of endoplasmic reticulum stress induced eif2 alpha phosphorylation", "Negative regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Negative regulation of endoplasmic reticulum unfolded protein response", "Negative regulation of endothelial cell apoptotic process", "Negative regulation of endothelial cell proliferation", "Negative regulation of epidermal growth factor activated receptor activity", "Negative regulation of epithelial cell apoptotic process", "Negative regulation of epithelial cell differentiation", "Negative regulation of epithelial cell migration", "Negative regulation of epithelial cell proliferation", "Negative regulation of erad pathway", "Negative regulation of erbb signaling pathway", "Negative regulation of erk1 and erk2 cascade", "Negative regulation of erythrocyte differentiation", "Negative regulation of establishment of protein localization", "Negative regulation of establishment of protein localization to mitochondrion", "Negative regulation of excitatory postsynaptic potential", "Negative regulation of execution phase of apoptosis", "Negative regulation of exocytosis", "Negative regulation of extrinsic apoptotic signaling pathway", "Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Negative regulation of fat cell differentiation", "Negative regulation of fatty acid beta oxidation", "Negative regulation of fatty acid biosynthetic process", "Negative regulation of fatty acid metabolic process", "Negative regulation of fatty acid oxidation", "Negative regulation of fatty acid transport", "Negative regulation of feeding behavior", "Negative regulation of fibroblast apoptotic process", "Negative regulation of fibroblast migration", "Negative regulation of fibroblast proliferation", "Negative regulation of filopodium assembly", "Negative regulation of g protein coupled receptor signaling pathway", "Negative regulation of gene expression", "Negative regulation of gene expression epigenetic", "Negative regulation of glial cell differentiation", "Negative regulation of glial cell proliferation", "Negative regulation of gliogenesis", "Negative regulation of glucocorticoid metabolic process", "Negative regulation of gluconeogenesis", "Negative regulation of glucose import", "Negative regulation of glucose transmembrane transport", "Negative regulation of glycogen metabolic process", "Negative regulation of glycolytic process", "Negative regulation of glycoprotein metabolic process", "Negative regulation of golgi to plasma membrane protein transport", "Negative regulation of granulocyte chemotaxis", "Negative regulation of granulocyte differentiation", "Negative regulation of growth", "Negative regulation of gtpase activity", "Negative regulation of guanyl nucleotide exchange factor activity", "Negative regulation of heart rate", "Negative regulation of helicase activity", "Negative regulation of hematopoietic progenitor cell differentiation", "Negative regulation of hemopoiesis", "Negative regulation of histone acetylation", "Negative regulation of histone h3 k27 methylation", "Negative regulation of histone h3 k4 methylation", "Negative regulation of histone h3 k9 methylation", "Negative regulation of histone h3 k9 trimethylation", "Negative regulation of histone h4 acetylation", "Negative regulation of histone methylation", "Negative regulation of histone modification", "Negative regulation of histone phosphorylation", "Negative regulation of homotypic cell cell adhesion", "Negative regulation of hormone biosynthetic process", "Negative regulation of hormone metabolic process", "Negative regulation of hormone secretion", "Negative regulation of hydrogen peroxide mediated programmed cell death", "Negative regulation of hydrolase activity", "Negative regulation of hypoxia induced intrinsic apoptotic signaling pathway", "Negative regulation of i kappab kinase nf kappab signaling", "Negative regulation of immune effector process", "Negative regulation of immune response", "Negative regulation of immune system process", "Negative regulation of immunoglobulin production", "Negative regulation of inclusion body assembly", "Negative regulation of inflammatory response", "Negative regulation of inflammatory response to antigenic stimulus", "Negative regulation of innate immune response", "Negative regulation of insulin secretion involved in cellular response to glucose stimulus", "Negative regulation of interferon gamma production", "Negative regulation of interleukin 12 production", "Negative regulation of interleukin 13 production", "Negative regulation of interleukin 17 production", "Negative regulation of interleukin 2 production", "Negative regulation of interleukin 6 production", "Negative regulation of interleukin 8 production", "Negative regulation of intracellular estrogen receptor signaling pathway", "Negative regulation of intracellular protein transport", "Negative regulation of intracellular signal transduction", "Negative regulation of intracellular steroid hormone receptor signaling pathway", "Negative regulation of intracellular transport", "Negative regulation of intrinsic apoptotic signaling pathway", "Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Negative regulation of ion transmembrane transport", "Negative regulation of ion transmembrane transporter activity", "Negative regulation of ion transport", "Negative regulation of ire1 mediated unfolded protein response", "Negative regulation of isotype switching", "Negative regulation of jnk cascade", "Negative regulation of jun kinase activity", "Negative regulation of keratinocyte proliferation", "Negative regulation of kinase activity", "Negative regulation of lamellipodium assembly", "Negative regulation of lamellipodium organization", "Negative regulation of leukocyte apoptotic process", "Negative regulation of leukocyte cell cell adhesion", "Negative regulation of leukocyte chemotaxis", "Negative regulation of leukocyte degranulation", "Negative regulation of leukocyte mediated immunity", "Negative regulation of leukocyte migration", "Negative regulation of leukocyte proliferation", "Negative regulation of lipase activity", "Negative regulation of lipid biosynthetic process", "Negative regulation of lipid catabolic process", "Negative regulation of lipid localization", "Negative regulation of lipid metabolic process", "Negative regulation of lipid transport", "Negative regulation of lipopolysaccharide mediated signaling pathway", "Negative regulation of lipoprotein lipase activity", "Negative regulation of lipoprotein particle clearance", "Negative regulation of locomotion", "Negative regulation of long term synaptic potentiation", "Negative regulation of low density lipoprotein particle clearance", "Negative regulation of low density lipoprotein receptor activity", "Negative regulation of lyase activity", "Negative regulation of lymphocyte activation", "Negative regulation of lymphocyte apoptotic process", "Negative regulation of lymphocyte differentiation", "Negative regulation of lymphocyte mediated immunity", "Negative regulation of lymphocyte migration", "Negative regulation of macroautophagy", "Negative regulation of macrophage chemotaxis", "Negative regulation of macrophage migration", "Negative regulation of map kinase activity", "Negative regulation of mapk cascade", "Negative regulation of mast cell activation", "Negative regulation of mast cell activation involved in immune response", "Negative regulation of mast cell degranulation", "Negative regulation of megakaryocyte differentiation", "Negative regulation of meiotic cell cycle", "Negative regulation of meiotic nuclear division", "Negative regulation of membrane permeability", "Negative regulation of membrane potential", "Negative regulation of mesenchymal cell proliferation", "Negative regulation of metalloendopeptidase activity", "Negative regulation of metallopeptidase activity", "Negative regulation of metaphase anaphase transition of cell cycle", "Negative regulation of mhc class ii biosynthetic process", "Negative regulation of microtubule polymerization", "Negative regulation of microtubule polymerization or depolymerization", "Negative regulation of mitochondrial fusion", "Negative regulation of mitochondrial membrane permeability", "Negative regulation of mitochondrial membrane permeability involved in apoptotic process", "Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Negative regulation of mitochondrion organization", "Negative regulation of mitophagy", "Negative regulation of mitotic cell cycle", "Negative regulation of mitotic cell cycle phase transition", "Negative regulation of molecular function", "Negative regulation of monocyte chemotaxis", "Negative regulation of monocyte differentiation", "Negative regulation of mononuclear cell migration", "Negative regulation of monooxygenase activity", "Negative regulation of mrna 3 end processing", "Negative regulation of mrna catabolic process", "Negative regulation of mrna metabolic process", "Negative regulation of mrna processing", "Negative regulation of mrna splicing via spliceosome", "Negative regulation of multicellular organism growth", "Negative regulation of multicellular organismal process", "Negative regulation of muscle adaptation", "Negative regulation of muscle cell apoptotic process", "Negative regulation of muscle cell differentiation", "Negative regulation of muscle contraction", "Negative regulation of muscle hypertrophy", "Negative regulation of muscle organ development", "Negative regulation of muscle tissue development", "Negative regulation of myeloid cell apoptotic process", "Negative regulation of myeloid cell differentiation", "Negative regulation of myeloid leukocyte differentiation", "Negative regulation of myeloid leukocyte mediated immunity", "Negative regulation of myoblast differentiation", "Negative regulation of myosin light chain phosphatase activity", "Negative regulation of myotube differentiation", "Negative regulation of natural killer cell mediated immunity", "Negative regulation of necrotic cell death", "Negative regulation of nervous system development", "Negative regulation of neural precursor cell proliferation", "Negative regulation of neuroblast proliferation", "Negative regulation of neuron apoptotic process", "Negative regulation of neuron death", "Negative regulation of neuron differentiation", "Negative regulation of neuron migration", "Negative regulation of neuron projection development", "Negative regulation of neuron projection regeneration", "Negative regulation of neurotransmitter secretion", "Negative regulation of neurotransmitter transport", "Negative regulation of neutrophil migration", "Negative regulation of nf kappab transcription factor activity", "Negative regulation of nik nf kappab signaling", "Negative regulation of nitric oxide metabolic process", "Negative regulation of nitric oxide synthase activity", "Negative regulation of nlrp3 inflammasome complex assembly", "Negative regulation of notch signaling pathway", "Negative regulation of nuclear division", "Negative regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Negative regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Negative regulation of nuclease activity", "Negative regulation of nucleobase containing compound metabolic process", "Negative regulation of nucleocytoplasmic transport", "Negative regulation of nucleotide biosynthetic process", "Negative regulation of nucleotide metabolic process", "Negative regulation of oligodendrocyte differentiation", "Negative regulation of organ growth", "Negative regulation of organelle assembly", "Negative regulation of organelle organization", "Negative regulation of organic acid transport", "Negative regulation of osteoblast differentiation", "Negative regulation of osteoblast proliferation", "Negative regulation of osteoclast differentiation", "Negative regulation of oxidative phosphorylation", "Negative regulation of oxidative stress induced cell death", "Negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Negative regulation of oxidative stress induced neuron death", "Negative regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway", "Negative regulation of oxidoreductase activity", "Negative regulation of p38mapk cascade", "Negative regulation of peptidase activity", "Negative regulation of peptide secretion", "Negative regulation of peptidyl cysteine s nitrosylation", "Negative regulation of peptidyl lysine acetylation", "Negative regulation of peptidyl serine phosphorylation", "Negative regulation of peptidyl threonine phosphorylation", "Negative regulation of peptidyl tyrosine phosphorylation", "Negative regulation of perk mediated unfolded protein response", "Negative regulation of phagocytosis", "Negative regulation of phosphatase activity", "Negative regulation of phosphatidylinositol 3 kinase signaling", "Negative regulation of phospholipase activity", "Negative regulation of phospholipid metabolic process", "Negative regulation of phosphoprotein phosphatase activity", "Negative regulation of phosphorus metabolic process", "Negative regulation of phosphorylation", "Negative regulation of plasma membrane bounded cell projection assembly", "Negative regulation of platelet derived growth factor receptor signaling pathway", "Negative regulation of posttranscriptional gene silencing", "Negative regulation of potassium ion transmembrane transport", "Negative regulation of potassium ion transport", "Negative regulation of production of mirnas involved in gene silencing by mirna", "Negative regulation of production of molecular mediator of immune response", "Negative regulation of programmed necrotic cell death", "Negative regulation of proteasomal protein catabolic process", "Negative regulation of proteasomal ubiquitin dependent protein catabolic process", "Negative regulation of protein acetylation", "Negative regulation of protein autophosphorylation", "Negative regulation of protein binding", "Negative regulation of protein catabolic process", "Negative regulation of protein containing complex assembly", "Negative regulation of protein containing complex disassembly", "Negative regulation of protein dephosphorylation", "Negative regulation of protein export from nucleus", "Negative regulation of protein import into nucleus", "Negative regulation of protein k63 linked ubiquitination", "Negative regulation of protein kinase activity by regulation of protein phosphorylation", "Negative regulation of protein kinase b signaling", "Negative regulation of protein localization", "Negative regulation of protein localization to cell periphery", "Negative regulation of protein localization to cell surface", "Negative regulation of protein localization to membrane", "Negative regulation of protein localization to nucleus", "Negative regulation of protein maturation", "Negative regulation of protein metabolic process", "Negative regulation of protein modification by small protein conjugation or removal", "Negative regulation of protein modification process", "Negative regulation of protein polymerization", "Negative regulation of protein polyubiquitination", "Negative regulation of protein secretion", "Negative regulation of protein serine threonine kinase activity", "Negative regulation of protein sumoylation", "Negative regulation of protein targeting to membrane", "Negative regulation of protein targeting to mitochondrion", "Negative regulation of protein tyrosine kinase activity", "Negative regulation of proteolysis", "Negative regulation of proteolysis involved in cellular protein catabolic process", "Negative regulation of reactive oxygen species biosynthetic process", "Negative regulation of reactive oxygen species metabolic process", "Negative regulation of receptor binding", "Negative regulation of receptor internalization", "Negative regulation of receptor mediated endocytosis", "Negative regulation of receptor signaling pathway via jak stat", "Negative regulation of receptor signaling pathway via stat", "Negative regulation of regulated secretory pathway", "Negative regulation of release of cytochrome c from mitochondria", "Negative regulation of reproductive process", "Negative regulation of respiratory burst", "Negative regulation of respiratory burst involved in inflammatory response", "Negative regulation of response to biotic stimulus", "Negative regulation of response to cytokine stimulus", "Negative regulation of response to dna damage stimulus", "Negative regulation of response to endoplasmic reticulum stress", "Negative regulation of response to external stimulus", "Negative regulation of response to food", "Negative regulation of response to oxidative stress", "Negative regulation of response to reactive oxygen species", "Negative regulation of response to stimulus", "Negative regulation of response to wounding", "Negative regulation of retinoic acid receptor signaling pathway", "Negative regulation of rho protein signal transduction", "Negative regulation of rig i signaling pathway", "Negative regulation of rna catabolic process", "Negative regulation of rna splicing", "Negative regulation of ruffle assembly", "Negative regulation of ryanodine sensitive calcium release channel activity", "Negative regulation of schwann cell proliferation", "Negative regulation of secretion", "Negative regulation of signal transduction by p53 class mediator", "Negative regulation of signal transduction in absence of ligand", "Negative regulation of signaling", "Negative regulation of signaling receptor activity", "Negative regulation of single stranded viral rna replication via double stranded dna intermediate", "Negative regulation of sister chromatid cohesion", "Negative regulation of small gtpase mediated signal transduction", "Negative regulation of small molecule metabolic process", "Negative regulation of smooth muscle cell apoptotic process", "Negative regulation of smooth muscle cell differentiation", "Negative regulation of smooth muscle cell migration", "Negative regulation of smooth muscle cell proliferation", "Negative regulation of smoothened signaling pathway", "Negative regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Negative regulation of sodium ion transmembrane transport", "Negative regulation of sodium ion transport", "Negative regulation of stem cell differentiation", "Negative regulation of steroid metabolic process", "Negative regulation of stress activated protein kinase signaling cascade", "Negative regulation of striated muscle cell apoptotic process", "Negative regulation of striated muscle cell differentiation", "Negative regulation of striated muscle contraction", "Negative regulation of supramolecular fiber organization", "Negative regulation of synapse assembly", "Negative regulation of synapse organization", "Negative regulation of synaptic transmission", "Negative regulation of synaptic transmission glutamatergic", "Negative regulation of synaptic vesicle exocytosis", "Negative regulation of systemic arterial blood pressure", "Negative regulation of t cell apoptotic process", "Negative regulation of t cell differentiation", "Negative regulation of t cell proliferation", "Negative regulation of t cell receptor signaling pathway", "Negative regulation of t helper cell differentiation", "Negative regulation of telomerase activity", "Negative regulation of telomere capping", "Negative regulation of telomere maintenance", "Negative regulation of telomere maintenance via telomerase", "Negative regulation of telomere maintenance via telomere lengthening", "Negative regulation of tissue remodeling", "Negative regulation of toll like receptor signaling pathway", "Negative regulation of tor signaling", "Negative regulation of transcription by competitive promoter binding", "Negative regulation of transcription by rna polymerase i", "Negative regulation of transcription by rna polymerase ii", "Negative regulation of transcription from rna polymerase ii promoter in response to stress", "Negative regulation of transcription initiation from rna polymerase ii promoter", "Negative regulation of transcription regulatory region dna binding", "Negative regulation of transferase activity", "Negative regulation of transforming growth factor beta production", "Negative regulation of transforming growth factor beta receptor signaling pathway", "Negative regulation of transforming growth factor beta1 production", "Negative regulation of translational elongation", "Negative regulation of translational initiation", "Negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Negative regulation of transmembrane transport", "Negative regulation of transport", "Negative regulation of transporter activity", "Negative regulation of trophoblast cell migration", "Negative regulation of tumor necrosis factor superfamily cytokine production", "Negative regulation of type 2 immune response", "Negative regulation of type b pancreatic cell apoptotic process", "Negative regulation of type i interferon mediated signaling pathway", "Negative regulation of type i interferon production", "Negative regulation of tyrosine phosphorylation of stat protein", "Negative regulation of ubiquitin dependent protein catabolic process", "Negative regulation of ubiquitin protein ligase activity", "Negative regulation of ubiquitin protein transferase activity", "Negative regulation of vascular associated smooth muscle cell apoptotic process", "Negative regulation of vascular associated smooth muscle cell differentiation", "Negative regulation of vascular associated smooth muscle cell migration", "Negative regulation of vascular associated smooth muscle cell proliferation", "Negative regulation of vascular endothelial growth factor production", "Negative regulation of vascular endothelial growth factor receptor signaling pathway", "Negative regulation of vascular permeability", "Negative regulation of vascular wound healing", "Negative regulation of vasculature development", "Negative regulation of viral entry into host cell", "Negative regulation of viral genome replication", "Negative regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Negative regulation of viral life cycle", "Negative regulation of viral process", "Negative regulation of viral transcription", "Negative regulation of vitamin metabolic process", "Negative regulation of voltage gated calcium channel activity", "Negative regulation of voltage gated potassium channel activity", "Negative regulation of wnt signaling pathway", "Negative regulation of wound healing", "Nephric duct development", "Nephric duct morphogenesis", "Nephron development", "Nephron epithelium development", "Nephron morphogenesis", "Nephron tubule epithelial cell differentiation", "Nephron tubule formation", "Nerve development", "Nerve growth factor signaling pathway", "Nervous system process", "Nervous system process involved in regulation of systemic arterial blood pressure", "Neural crest cell differentiation", "Neural crest cell migration", "Neural crest formation", "Neural nucleus development", "Neural plate development", "Neural precursor cell proliferation", "Neural retina development", "Neural tube development", "Neural tube formation", "Neural tube patterning", "Neuroblast division", "Neuroblast proliferation", "Neuroendocrine cell differentiation", "Neuroepithelial cell differentiation", "Neurofilament cytoskeleton organization", "Neurogenesis", "Neuroinflammatory response", "Neuromuscular junction development", "Neuromuscular process", "Neuromuscular process controlling balance", "Neuromuscular process controlling posture", "Neuromuscular synaptic transmission", "Neuron apoptotic process", "Neuron cellular homeostasis", "Neuron death", "Neuron death in response to hydrogen peroxide", "Neuron death in response to oxidative stress", "Neuron development", "Neuron differentiation", "Neuron fate commitment", "Neuron fate determination", "Neuron intrinsic apoptotic signaling pathway in response to oxidative stress", "Neuron maturation", "Neuron migration", "Neuron projection arborization", "Neuron projection extension", "Neuron projection extension involved in neuron projection guidance", "Neuron projection guidance", "Neuron projection maintenance", "Neuron projection organization", "Neuron projection regeneration", "Neuron recognition", "Neuron remodeling", "Neuronal action potential", "Neuronal ion channel clustering", "Neuronal stem cell population maintenance", "Neuropeptide signaling pathway", "Neurotransmitter biosynthetic process", "Neurotransmitter catabolic process", "Neurotransmitter gated ion channel clustering", "Neurotransmitter metabolic process", "Neurotransmitter receptor internalization", "Neurotransmitter receptor localization to postsynaptic specialization membrane", "Neurotransmitter receptor transport", "Neurotransmitter receptor transport endosome to postsynaptic membrane", "Neurotransmitter receptor transport postsynaptic endosome to lysosome", "Neurotransmitter receptor transport to plasma membrane", "Neurotransmitter reuptake", "Neurotransmitter secretion", "Neurotransmitter transport", "Neurotransmitter uptake", "Neurotrophin production", "Neurotrophin signaling pathway", "Neurotrophin trk receptor signaling pathway", "Neutral amino acid transport", "Neutral lipid biosynthetic process", "Neutral lipid catabolic process", "Neutral lipid metabolic process", "Neutrophil activation involved in immune response", "Neutrophil apoptotic process", "Neutrophil chemotaxis", "Neutrophil clearance", "Neutrophil degranulation", "Neutrophil differentiation", "Neutrophil homeostasis", "Neutrophil mediated immunity", "Neutrophil migration", "Nik nf kappab signaling", "Nitric oxide mediated signal transduction", "Nitric oxide synthase biosynthetic process", "Nitrogen compound transport", "Nk t cell activation", "Nk t cell differentiation", "Nls bearing protein import into nucleus", "Non canonical wnt signaling pathway", "Non lytic viral release", "Non membrane bounded organelle assembly", "Non motile cilium assembly", "Nonribosomal peptide biosynthetic process", "Nose development", "Notch receptor processing", "Notch signaling pathway", "Nuclear body organization", "Nuclear chromosome segregation", "Nuclear envelope organization", "Nuclear export", "Nuclear membrane organization", "Nuclear membrane reassembly", "Nuclear migration", "Nuclear ncrna surveillance", "Nuclear pore complex assembly", "Nuclear pore organization", "Nuclear transcribed mrna catabolic process", "Nuclear transcribed mrna catabolic process deadenylation dependent decay", "Nuclear transcribed mrna catabolic process deadenylation independent decay", "Nuclear transcribed mrna catabolic process exonucleolytic", "Nuclear transcribed mrna catabolic process exonucleolytic 3 5", "Nuclear transcribed mrna catabolic process nonsense mediated decay", "Nuclear transcribed mrna poly a tail shortening", "Nuclear transport", "Nucleic acid phosphodiester bond hydrolysis", "Nucleobase biosynthetic process", "Nucleobase catabolic process", "Nucleobase containing compound transport", "Nucleobase containing small molecule biosynthetic process", "Nucleobase containing small molecule catabolic process", "Nucleobase containing small molecule interconversion", "Nucleobase containing small molecule metabolic process", "Nucleobase metabolic process", "Nucleobase transport", "Nucleolar chromatin organization", "Nucleolar large rrna transcription by rna polymerase i", "Nucleolus organization", "Nucleoside bisphosphate biosynthetic process", "Nucleoside bisphosphate catabolic process", "Nucleoside bisphosphate metabolic process", "Nucleoside catabolic process", "Nucleoside diphosphate biosynthetic process", "Nucleoside diphosphate catabolic process", "Nucleoside diphosphate metabolic process", "Nucleoside metabolic process", "Nucleoside monophosphate biosynthetic process", "Nucleoside monophosphate catabolic process", "Nucleoside monophosphate metabolic process", "Nucleoside monophosphate phosphorylation", "Nucleoside phosphate biosynthetic process", "Nucleoside phosphate catabolic process", "Nucleoside salvage", "Nucleoside triphosphate biosynthetic process", "Nucleoside triphosphate catabolic process", "Nucleoside triphosphate metabolic process", "Nucleosome assembly", "Nucleosome mobilization", "Nucleosome organization", "Nucleosome positioning", "Nucleotide binding domain leucine rich repeat containing receptor signaling pathway", "Nucleotide binding oligomerization domain containing 2 signaling pathway", "Nucleotide excision repair", "Nucleotide excision repair dna gap filling", "Nucleotide excision repair dna incision", "Nucleotide phosphorylation", "Nucleotide salvage", "Nucleotide sugar biosynthetic process", "Nucleotide sugar metabolic process", "Nucleotide sugar transmembrane transport", "Nucleotide transmembrane transport", "Nucleotide transport", "Nucleus localization", "Nucleus organization", "O glycan processing", "Observational learning", "Odontoblast differentiation", "Odontogenesis", "Odontogenesis of dentin containing tooth", "Olefinic compound biosynthetic process", "Olefinic compound metabolic process", "Olfactory behavior", "Olfactory bulb interneuron development", "Olfactory bulb interneuron differentiation", "Olfactory lobe development", "Oligodendrocyte development", "Oligodendrocyte differentiation", "Oligodendrocyte progenitor proliferation", "Oligopeptide transport", "Oligosaccharide catabolic process", "Oligosaccharide lipid intermediate biosynthetic process", "Oligosaccharide metabolic process", "One carbon metabolic process", "Oocyte construction", "Oocyte differentiation", "Oocyte maturation", "Oogenesis", "Optic nerve development", "Organ growth", "Organ induction", "Organ or tissue specific immune response", "Organelle assembly", "Organelle disassembly", "Organelle fission", "Organelle fusion", "Organelle inheritance", "Organelle localization", "Organelle membrane fusion", "Organelle transport along microtubule", "Organic acid biosynthetic process", "Organic acid catabolic process", "Organic acid metabolic process", "Organic acid transmembrane transport", "Organic acid transport", "Organic anion transport", "Organic cation transport", "Organic cyclic compound catabolic process", "Organic hydroxy compound biosynthetic process", "Organic hydroxy compound catabolic process", "Organic hydroxy compound metabolic process", "Organic hydroxy compound transport", "Organism emergence from protective structure", "Organonitrogen compound biosynthetic process", "Organonitrogen compound catabolic process", "Organophosphate biosynthetic process", "Organophosphate catabolic process", "Organophosphate ester transport", "Organophosphate metabolic process", "Ornithine metabolic process", "Ornithine transport", "Ossification", "Osteoblast differentiation", "Osteoblast proliferation", "Osteoclast development", "Osteoclast differentiation", "Otolith development", "Outer dynein arm assembly", "Outer mitochondrial membrane organization", "Outflow tract morphogenesis", "Ovarian follicle development", "Oviduct development", "Ovulation cycle", "Ovulation cycle process", "Oxaloacetate metabolic process", "Oxaloacetate transport", "Oxidative demethylation", "Oxidative dna demethylation", "Oxidative phosphorylation", "Oxidative rna demethylation", "Oxygen homeostasis", "P body assembly", "P38mapk cascade", "Pallium development", "Pancreas development", "Pancreatic juice secretion", "Pantothenate metabolic process", "Parallel actin filament bundle assembly", "Paranodal junction assembly", "Parathyroid gland development", "Paraxial mesoderm development", "Paraxial mesoderm formation", "Paraxial mesoderm morphogenesis", "Parkin mediated stimulation of mitophagy in response to mitochondrial depolarization", "Pathway restricted smad protein phosphorylation", "Pattern recognition receptor signaling pathway", "Pattern specification process", "Penetration of zona pellucida", "Pentose catabolic process", "Pentose metabolic process", "Pentose phosphate shunt", "Pentose phosphate shunt non oxidative branch", "Peptide antigen assembly with mhc protein complex", "Peptide biosynthetic process", "Peptide catabolic process", "Peptide cross linking", "Peptide metabolic process", "Peptide transport", "Peptidyl amino acid modification", "Peptidyl arginine methylation", "Peptidyl arginine methylation to asymmetrical dimethyl arginine", "Peptidyl arginine modification", "Peptidyl arginine n methylation", "Peptidyl asparagine modification", "Peptidyl cysteine modification", "Peptidyl diphthamide biosynthetic process from peptidyl histidine", "Peptidyl glutamic acid modification", "Peptidyl glutamine methylation", "Peptidyl histidine modification", "Peptidyl l cysteine s palmitoylation", "Peptidyl lysine acetylation", "Peptidyl lysine deacetylation", "Peptidyl lysine dimethylation", "Peptidyl lysine hydroxylation", "Peptidyl lysine methylation", "Peptidyl lysine modification", "Peptidyl lysine trimethylation", "Peptidyl methionine modification", "Peptidyl proline hydroxylation", "Peptidyl proline hydroxylation to 4 hydroxy l proline", "Peptidyl proline modification", "Peptidyl serine autophosphorylation", "Peptidyl serine dephosphorylation", "Peptidyl serine modification", "Peptidyl threonine dephosphorylation", "Peptidyl threonine modification", "Peptidyl tyrosine dephosphorylation", "Peptidyl tyrosine dephosphorylation involved in inactivation of protein kinase activity", "Peptidyl tyrosine modification", "Peripheral nervous system axon regeneration", "Peripheral nervous system development", "Peripheral nervous system myelin maintenance", "Perk mediated unfolded protein response", "Peroxisomal transport", "Peroxisome fission", "Peroxisome organization", "Peroxisome proliferator activated receptor signaling pathway", "Ph reduction", "Phagocytosis", "Phagocytosis recognition", "Phagolysosome assembly", "Phagosome acidification", "Phagosome lysosome fusion", "Phagosome maturation", "Pharyngeal system development", "Phenol containing compound biosynthetic process", "Phenol containing compound catabolic process", "Phenol containing compound metabolic process", "Phenotypic switching", "Phosphagen metabolic process", "Phosphate ion transmembrane transport", "Phosphate ion transport", "Phosphatidic acid metabolic process", "Phosphatidylcholine acyl chain remodeling", "Phosphatidylcholine biosynthetic process", "Phosphatidylcholine catabolic process", "Phosphatidylcholine metabolic process", "Phosphatidylethanolamine biosynthetic process", "Phosphatidylethanolamine metabolic process", "Phosphatidylglycerol acyl chain remodeling", "Phosphatidylglycerol biosynthetic process", "Phosphatidylglycerol metabolic process", "Phosphatidylinositol 3 kinase signaling", "Phosphatidylinositol acyl chain remodeling", "Phosphatidylinositol biosynthetic process", "Phosphatidylinositol dephosphorylation", "Phosphatidylinositol metabolic process", "Phosphatidylinositol phosphate biosynthetic process", "Phosphatidylserine metabolic process", "Phospholipase c activating dopamine receptor signaling pathway", "Phospholipase c activating g protein coupled receptor signaling pathway", "Phospholipid biosynthetic process", "Phospholipid catabolic process", "Phospholipid dephosphorylation", "Phospholipid metabolic process", "Phospholipid transport", "Phosphorylation", "Phosphorylation of rna polymerase ii c terminal domain", "Photoperiodism", "Photoreceptor cell development", "Photoreceptor cell differentiation", "Photoreceptor cell maintenance", "Photoreceptor cell outer segment organization", "Phototransduction", "Phototransduction visible light", "Physiological cardiac muscle hypertrophy", "Pigment accumulation", "Pigment biosynthetic process", "Pigment cell differentiation", "Pigment granule localization", "Pigment granule maturation", "Pigment granule organization", "Pigment metabolic process", "Pigmentation", "Pinocytosis", "Pirna metabolic process", "Pituitary gland development", "Placenta blood vessel development", "Placenta development", "Planar cell polarity pathway involved in neural tube closure", "Plasma lipoprotein particle clearance", "Plasma membrane fusion", "Plasma membrane organization", "Plasma membrane raft assembly", "Plasma membrane raft organization", "Plasma membrane repair", "Plasma membrane to endosome transport", "Plasma membrane tubulation", "Plasminogen activation", "Platelet activating factor metabolic process", "Platelet activation", "Platelet aggregation", "Platelet degranulation", "Platelet derived growth factor receptor beta signaling pathway", "Platelet derived growth factor receptor signaling pathway", "Platelet morphogenesis", "Plus end directed organelle transport along microtubule", "Pml body organization", "Podosome assembly", "Pointed end actin filament capping", "Polarized epithelial cell differentiation", "Poly a plus mrna export from nucleus", "Poly n acetyllactosamine metabolic process", "Polyadenylation dependent rna catabolic process", "Polyadenylation dependent snorna 3 end processing", "Polyamine biosynthetic process", "Polyamine metabolic process", "Polyketide metabolic process", "Polyol biosynthetic process", "Polyol catabolic process", "Polyol metabolic process", "Polyprenol metabolic process", "Polysaccharide biosynthetic process", "Polysaccharide catabolic process", "Polysaccharide metabolic process", "Pons development", "Pore complex assembly", "Porphyrin containing compound metabolic process", "Positive chemotaxis", "Positive regulation by host of viral genome replication", "Positive regulation by host of viral process", "Positive regulation by host of viral transcription", "Positive regulation by symbiont of entry into host", "Positive regulation of 3 utr mediated mrna stabilization", "Positive regulation of actin cytoskeleton reorganization", "Positive regulation of actin filament bundle assembly", "Positive regulation of actin filament depolymerization", "Positive regulation of actin filament polymerization", "Positive regulation of actin nucleation", "Positive regulation of action potential", "Positive regulation of activated t cell proliferation", "Positive regulation of activin receptor signaling pathway", "Positive regulation of acute inflammatory response", "Positive regulation of acute inflammatory response to antigenic stimulus", "Positive regulation of adaptive immune response", "Positive regulation of alcohol biosynthetic process", "Positive regulation of alpha beta t cell activation", "Positive regulation of alpha beta t cell differentiation", "Positive regulation of alpha beta t cell proliferation", "Positive regulation of amine transport", "Positive regulation of amino acid transport", "Positive regulation of amyloid beta clearance", "Positive regulation of amyloid beta formation", "Positive regulation of amyloid precursor protein biosynthetic process", "Positive regulation of amyloid precursor protein catabolic process", "Positive regulation of animal organ morphogenesis", "Positive regulation of anion transmembrane transport", "Positive regulation of anion transport", "Positive regulation of anoikis", "Positive regulation of antigen receptor mediated signaling pathway", "Positive regulation of apoptotic signaling pathway", "Positive regulation of arp2 3 complex mediated actin nucleation", "Positive regulation of aspartic type peptidase activity", "Positive regulation of astrocyte differentiation", "Positive regulation of atp biosynthetic process", "Positive regulation of atp dependent activity", "Positive regulation of atp metabolic process", "Positive regulation of attachment of spindle microtubules to kinetochore", "Positive regulation of autophagy", "Positive regulation of autophagy of mitochondrion", "Positive regulation of axon extension", "Positive regulation of axonogenesis", "Positive regulation of b cell activation", "Positive regulation of b cell mediated immunity", "Positive regulation of b cell proliferation", "Positive regulation of basement membrane assembly involved in embryonic body morphogenesis", "Positive regulation of behavior", "Positive regulation of binding", "Positive regulation of biomineralization", "Positive regulation of blood brain barrier permeability", "Positive regulation of blood circulation", "Positive regulation of blood pressure", "Positive regulation of blood vessel endothelial cell migration", "Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Positive regulation of bmp signaling pathway", "Positive regulation of bone mineralization", "Positive regulation of bone resorption", "Positive regulation of brown fat cell differentiation", "Positive regulation of calcineurin mediated signaling", "Positive regulation of calcium ion dependent exocytosis", "Positive regulation of calcium ion transmembrane transport", "Positive regulation of calcium ion transmembrane transporter activity", "Positive regulation of calcium ion transport", "Positive regulation of calcium ion transport into cytosol", "Positive regulation of calcium mediated signaling", "Positive regulation of camp dependent protein kinase activity", "Positive regulation of canonical wnt signaling pathway", "Positive regulation of carbohydrate metabolic process", "Positive regulation of cardiac muscle cell proliferation", "Positive regulation of cardioblast differentiation", "Positive regulation of cardiocyte differentiation", "Positive regulation of cartilage development", "Positive regulation of catabolic process", "Positive regulation of catalytic activity", "Positive regulation of catecholamine metabolic process", "Positive regulation of cation channel activity", "Positive regulation of cd4 positive alpha beta t cell activation", "Positive regulation of cd4 positive alpha beta t cell differentiation", "Positive regulation of cd8 positive alpha beta t cell activation", "Positive regulation of cell activation", "Positive regulation of cell adhesion", "Positive regulation of cell adhesion molecule production", "Positive regulation of cell aging", "Positive regulation of cell cell adhesion", "Positive regulation of cell cell adhesion mediated by cadherin", "Positive regulation of cell cycle", "Positive regulation of cell cycle checkpoint", "Positive regulation of cell cycle g1 s phase transition", "Positive regulation of cell cycle g2 m phase transition", "Positive regulation of cell cycle phase transition", "Positive regulation of cell cycle process", "Positive regulation of cell death", "Positive regulation of cell development", "Positive regulation of cell differentiation", "Positive regulation of cell division", "Positive regulation of cell growth", "Positive regulation of cell growth involved in cardiac muscle cell development", "Positive regulation of cell junction assembly", "Positive regulation of cell killing", "Positive regulation of cell matrix adhesion", "Positive regulation of cell maturation", "Positive regulation of cell migration by vascular endothelial growth factor signaling pathway", "Positive regulation of cell migration involved in sprouting angiogenesis", "Positive regulation of cell morphogenesis involved in differentiation", "Positive regulation of cell population proliferation", "Positive regulation of cell projection organization", "Positive regulation of cell size", "Positive regulation of cell substrate adhesion", "Positive regulation of cell substrate junction organization", "Positive regulation of cellular amide metabolic process", "Positive regulation of cellular amine metabolic process", "Positive regulation of cellular biosynthetic process", "Positive regulation of cellular carbohydrate metabolic process", "Positive regulation of cellular component biogenesis", "Positive regulation of cellular component organization", "Positive regulation of cellular protein catabolic process", "Positive regulation of cellular respiration", "Positive regulation of cellular response to insulin stimulus", "Positive regulation of cellular response to transforming growth factor beta stimulus", "Positive regulation of centriole elongation", "Positive regulation of centriole replication", "Positive regulation of chemokine c c motif ligand 5 production", "Positive regulation of chemokine c x c motif ligand 2 production", "Positive regulation of chemokine production", "Positive regulation of chemotaxis", "Positive regulation of cholesterol biosynthetic process", "Positive regulation of cholesterol metabolic process", "Positive regulation of cholesterol storage", "Positive regulation of chondrocyte differentiation", "Positive regulation of chromatin binding", "Positive regulation of chromatin organization", "Positive regulation of chromosome condensation", "Positive regulation of chromosome organization", "Positive regulation of chromosome segregation", "Positive regulation of chromosome separation", "Positive regulation of cilium assembly", "Positive regulation of circadian rhythm", "Positive regulation of clathrin dependent endocytosis", "Positive regulation of coagulation", "Positive regulation of cold induced thermogenesis", "Positive regulation of collagen metabolic process", "Positive regulation of collateral sprouting", "Positive regulation of complement activation", "Positive regulation of connective tissue replacement", "Positive regulation of cyclic nucleotide phosphodiesterase activity", "Positive regulation of cyclin dependent protein kinase activity", "Positive regulation of cysteine type endopeptidase activity", "Positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Positive regulation of cytokine production", "Positive regulation of cytokine production involved in immune response", "Positive regulation of cytokine production involved in inflammatory response", "Positive regulation of cytokinesis", "Positive regulation of cytoplasmic translation", "Positive regulation of cytoplasmic transport", "Positive regulation of cytoskeleton organization", "Positive regulation of defense response", "Positive regulation of defense response to virus by host", "Positive regulation of dendrite development", "Positive regulation of dendrite morphogenesis", "Positive regulation of dendritic cell cytokine production", "Positive regulation of dendritic cell differentiation", "Positive regulation of dendritic spine development", "Positive regulation of dendritic spine morphogenesis", "Positive regulation of deoxyribonuclease activity", "Positive regulation of dephosphorylation", "Positive regulation of developmental growth", "Positive regulation of developmental process", "Positive regulation of dna binding", "Positive regulation of dna binding transcription factor activity", "Positive regulation of dna biosynthetic process", "Positive regulation of dna damage response signal transduction by p53 class mediator", "Positive regulation of dna demethylation", "Positive regulation of dna dependent dna replication", "Positive regulation of dna ligation", "Positive regulation of dna metabolic process", "Positive regulation of dna methylation dependent heterochromatin assembly", "Positive regulation of dna recombination", "Positive regulation of dna repair", "Positive regulation of dna replication", "Positive regulation of dna templated transcription elongation", "Positive regulation of dna templated transcription initiation", "Positive regulation of dopamine receptor signaling pathway", "Positive regulation of double strand break repair", "Positive regulation of double strand break repair via homologous recombination", "Positive regulation of double strand break repair via nonhomologous end joining", "Positive regulation of early endosome to late endosome transport", "Positive regulation of embryonic development", "Positive regulation of endocytic recycling", "Positive regulation of endocytosis", "Positive regulation of endoplasmic reticulum unfolded protein response", "Positive regulation of endothelial cell apoptotic process", "Positive regulation of endothelial cell chemotaxis", "Positive regulation of endothelial cell chemotaxis by vegf activated vascular endothelial growth factor receptor signaling pathway", "Positive regulation of endothelial cell development", "Positive regulation of endothelial cell differentiation", "Positive regulation of endothelial cell matrix adhesion via fibronectin", "Positive regulation of endothelial cell migration", "Positive regulation of endothelial cell proliferation", "Positive regulation of epidermal cell differentiation", "Positive regulation of epidermal growth factor activated receptor activity", "Positive regulation of epidermis development", "Positive regulation of epithelial cell apoptotic process", "Positive regulation of epithelial cell differentiation", "Positive regulation of epithelial cell migration", "Positive regulation of epithelial cell proliferation", "Positive regulation of epithelial cell proliferation involved in lung morphogenesis", "Positive regulation of epithelial to mesenchymal transition", "Positive regulation of er associated ubiquitin dependent protein catabolic process", "Positive regulation of erad pathway", "Positive regulation of erbb signaling pathway", "Positive regulation of erk1 and erk2 cascade", "Positive regulation of erythrocyte differentiation", "Positive regulation of establishment of protein localization", "Positive regulation of establishment of protein localization to mitochondrion", "Positive regulation of establishment of protein localization to telomere", "Positive regulation of excitatory postsynaptic potential", "Positive regulation of execution phase of apoptosis", "Positive regulation of exocytosis", "Positive regulation of exosomal secretion", "Positive regulation of extracellular matrix assembly", "Positive regulation of extracellular matrix disassembly", "Positive regulation of extracellular matrix organization", "Positive regulation of extrinsic apoptotic signaling pathway", "Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Positive regulation of fat cell differentiation", "Positive regulation of fatty acid beta oxidation", "Positive regulation of fatty acid biosynthetic process", "Positive regulation of fatty acid metabolic process", "Positive regulation of fatty acid oxidation", "Positive regulation of fatty acid transport", "Positive regulation of fc receptor mediated stimulatory signaling pathway", "Positive regulation of feeding behavior", "Positive regulation of fibroblast growth factor receptor signaling pathway", "Positive regulation of fibroblast migration", "Positive regulation of fibroblast proliferation", "Positive regulation of filopodium assembly", "Positive regulation of focal adhesion assembly", "Positive regulation of g protein coupled receptor signaling pathway", "Positive regulation of g0 to g1 transition", "Positive regulation of g1 s transition of mitotic cell cycle", "Positive regulation of gastrulation", "Positive regulation of gene expression", "Positive regulation of glial cell differentiation", "Positive regulation of glial cell migration", "Positive regulation of glial cell proliferation", "Positive regulation of gliogenesis", "Positive regulation of glucokinase activity", "Positive regulation of gluconeogenesis", "Positive regulation of glucose import", "Positive regulation of glucose metabolic process", "Positive regulation of glucose transmembrane transport", "Positive regulation of glutamate secretion", "Positive regulation of glycogen metabolic process", "Positive regulation of glycogen starch synthase activity", "Positive regulation of glycolytic process", "Positive regulation of glycoprotein metabolic process", "Positive regulation of golgi to plasma membrane protein transport", "Positive regulation of gonad development", "Positive regulation of granulocyte chemotaxis", "Positive regulation of granulocyte differentiation", "Positive regulation of growth", "Positive regulation of gtpase activity", "Positive regulation of hair follicle development", "Positive regulation of heart growth", "Positive regulation of heart rate", "Positive regulation of helicase activity", "Positive regulation of hematopoietic progenitor cell differentiation", "Positive regulation of hemopoiesis", "Positive regulation of heterotypic cell cell adhesion", "Positive regulation of hexokinase activity", "Positive regulation of hippo signaling", "Positive regulation of histone acetylation", "Positive regulation of histone deacetylation", "Positive regulation of histone h3 k27 methylation", "Positive regulation of histone h3 k4 methylation", "Positive regulation of histone h3 k9 acetylation", "Positive regulation of histone h3 k9 methylation", "Positive regulation of histone h4 acetylation", "Positive regulation of histone methylation", "Positive regulation of histone modification", "Positive regulation of histone phosphorylation", "Positive regulation of histone ubiquitination", "Positive regulation of homotypic cell cell adhesion", "Positive regulation of hormone biosynthetic process", "Positive regulation of hormone metabolic process", "Positive regulation of hormone secretion", "Positive regulation of humoral immune response", "Positive regulation of hydrogen peroxide metabolic process", "Positive regulation of hydrolase activity", "Positive regulation of i kappab kinase nf kappab signaling", "Positive regulation of i kappab phosphorylation", "Positive regulation of immune effector process", "Positive regulation of immune response", "Positive regulation of immune system process", "Positive regulation of immunoglobulin production", "Positive regulation of inclusion body assembly", "Positive regulation of inflammatory response", "Positive regulation of inflammatory response to antigenic stimulus", "Positive regulation of innate immune response", "Positive regulation of insulin like growth factor receptor signaling pathway", "Positive regulation of insulin secretion", "Positive regulation of insulin secretion involved in cellular response to glucose stimulus", "Positive regulation of integrin activation", "Positive regulation of integrin mediated signaling pathway", "Positive regulation of interferon alpha production", "Positive regulation of interferon beta production", "Positive regulation of interferon gamma production", "Positive regulation of interleukin 1 beta production", "Positive regulation of interleukin 1 production", "Positive regulation of interleukin 10 production", "Positive regulation of interleukin 12 production", "Positive regulation of interleukin 17 production", "Positive regulation of interleukin 18 production", "Positive regulation of interleukin 2 production", "Positive regulation of interleukin 6 production", "Positive regulation of interleukin 8 production", "Positive regulation of intracellular lipid transport", "Positive regulation of intracellular protein transport", "Positive regulation of intracellular signal transduction", "Positive regulation of intracellular steroid hormone receptor signaling pathway", "Positive regulation of intracellular transport", "Positive regulation of intrinsic apoptotic signaling pathway", "Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Positive regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Positive regulation of ion transmembrane transport", "Positive regulation of ion transport", "Positive regulation of ire1 mediated unfolded protein response", "Positive regulation of isotype switching", "Positive regulation of isotype switching to iga isotypes", "Positive regulation of isotype switching to igg isotypes", "Positive regulation of jnk cascade", "Positive regulation of jun kinase activity", "Positive regulation of keratinocyte differentiation", "Positive regulation of keratinocyte proliferation", "Positive regulation of kinase activity", "Positive regulation of lamellipodium assembly", "Positive regulation of lamellipodium morphogenesis", "Positive regulation of lamellipodium organization", "Positive regulation of leukocyte adhesion to vascular endothelial cell", "Positive regulation of leukocyte apoptotic process", "Positive regulation of leukocyte cell cell adhesion", "Positive regulation of leukocyte chemotaxis", "Positive regulation of leukocyte degranulation", "Positive regulation of leukocyte mediated immunity", "Positive regulation of leukocyte migration", "Positive regulation of leukocyte proliferation", "Positive regulation of ligase activity", "Positive regulation of lipase activity", "Positive regulation of lipid biosynthetic process", "Positive regulation of lipid catabolic process", "Positive regulation of lipid kinase activity", "Positive regulation of lipid localization", "Positive regulation of lipid metabolic process", "Positive regulation of lipid storage", "Positive regulation of lipid transport", "Positive regulation of lipopolysaccharide mediated signaling pathway", "Positive regulation of lipoprotein particle clearance", "Positive regulation of locomotion", "Positive regulation of long term neuronal synaptic plasticity", "Positive regulation of long term synaptic depression", "Positive regulation of long term synaptic potentiation", "Positive regulation of low density lipoprotein receptor activity", "Positive regulation of lyase activity", "Positive regulation of lymphocyte anergy", "Positive regulation of lymphocyte apoptotic process", "Positive regulation of lymphocyte chemotaxis", "Positive regulation of lymphocyte differentiation", "Positive regulation of lymphocyte mediated immunity", "Positive regulation of lymphocyte migration", "Positive regulation of macroautophagy", "Positive regulation of macrophage activation", "Positive regulation of macrophage differentiation", "Positive regulation of maintenance of sister chromatid cohesion", "Positive regulation of mammary gland epithelial cell proliferation", "Positive regulation of map kinase activity", "Positive regulation of mapk cascade", "Positive regulation of mast cell activation", "Positive regulation of mast cell activation involved in immune response", "Positive regulation of megakaryocyte differentiation", "Positive regulation of meiotic cell cycle", "Positive regulation of meiotic nuclear division", "Positive regulation of membrane depolarization", "Positive regulation of membrane permeability", "Positive regulation of membrane potential", "Positive regulation of membrane protein ectodomain proteolysis", "Positive regulation of mesenchymal cell proliferation", "Positive regulation of mesenchymal stem cell proliferation", "Positive regulation of metalloendopeptidase activity", "Positive regulation of metallopeptidase activity", "Positive regulation of metaphase anaphase transition of cell cycle", "Positive regulation of mhc class i biosynthetic process", "Positive regulation of microtubule binding", "Positive regulation of microtubule nucleation", "Positive regulation of microtubule polymerization or depolymerization", "Positive regulation of mirna catabolic process", "Positive regulation of mirna mediated gene silencing by inhibition of translation", "Positive regulation of mirna metabolic process", "Positive regulation of mirna transcription", "Positive regulation of mitochondrial calcium ion concentration", "Positive regulation of mitochondrial depolarization", "Positive regulation of mitochondrial fission", "Positive regulation of mitochondrial membrane potential", "Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Positive regulation of mitochondrial translation", "Positive regulation of mitochondrion organization", "Positive regulation of mitophagy", "Positive regulation of mitophagy in response to mitochondrial depolarization", "Positive regulation of mitotic cell cycle", "Positive regulation of mitotic cell cycle phase transition", "Positive regulation of mitotic cell cycle spindle assembly checkpoint", "Positive regulation of mitotic nuclear division", "Positive regulation of molecular function", "Positive regulation of monocyte chemotaxis", "Positive regulation of monocyte differentiation", "Positive regulation of mononuclear cell migration", "Positive regulation of monooxygenase activity", "Positive regulation of morphogenesis of an epithelium", "Positive regulation of mrna 3 end processing", "Positive regulation of mrna metabolic process", "Positive regulation of mrna processing", "Positive regulation of mrna splicing via spliceosome", "Positive regulation of multicellular organism growth", "Positive regulation of multicellular organismal process", "Positive regulation of muscle cell apoptotic process", "Positive regulation of muscle cell differentiation", "Positive regulation of muscle contraction", "Positive regulation of muscle hypertrophy", "Positive regulation of muscle tissue development", "Positive regulation of myelination", "Positive regulation of myeloid cell apoptotic process", "Positive regulation of myeloid cell differentiation", "Positive regulation of myeloid leukocyte cytokine production involved in immune response", "Positive regulation of myeloid leukocyte differentiation", "Positive regulation of myeloid leukocyte mediated immunity", "Positive regulation of myoblast differentiation", "Positive regulation of myoblast fusion", "Positive regulation of myotube differentiation", "Positive regulation of nad p h oxidase activity", "Positive regulation of natural killer cell activation", "Positive regulation of natural killer cell mediated cytotoxicity", "Positive regulation of natural killer cell mediated immune response to tumor cell", "Positive regulation of natural killer cell mediated immunity", "Positive regulation of necrotic cell death", "Positive regulation of nervous system development", "Positive regulation of nervous system process", "Positive regulation of neural precursor cell proliferation", "Positive regulation of neuroblast proliferation", "Positive regulation of neurogenesis", "Positive regulation of neuron apoptotic process", "Positive regulation of neuron death", "Positive regulation of neuron differentiation", "Positive regulation of neuron migration", "Positive regulation of neuron projection arborization", "Positive regulation of neuron projection development", "Positive regulation of neuron projection regeneration", "Positive regulation of neurotransmitter secretion", "Positive regulation of neurotransmitter transport", "Positive regulation of neurotransmitter uptake", "Positive regulation of neurotrophin trk receptor signaling pathway", "Positive regulation of neutrophil migration", "Positive regulation of nf kappab transcription factor activity", "Positive regulation of nik nf kappab signaling", "Positive regulation of nitric oxide metabolic process", "Positive regulation of nitric oxide synthase activity", "Positive regulation of nitric oxide synthase biosynthetic process", "Positive regulation of nk t cell activation", "Positive regulation of nlrp3 inflammasome complex assembly", "Positive regulation of non motile cilium assembly", "Positive regulation of notch signaling pathway", "Positive regulation of nuclear cell cycle dna replication", "Positive regulation of nuclear division", "Positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Positive regulation of nuclease activity", "Positive regulation of nucleobase containing compound metabolic process", "Positive regulation of nucleobase containing compound transport", "Positive regulation of nucleocytoplasmic transport", "Positive regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Positive regulation of nucleotide binding oligomerization domain containing signaling pathway", "Positive regulation of nucleotide biosynthetic process", "Positive regulation of nucleotide metabolic process", "Positive regulation of oligodendrocyte differentiation", "Positive regulation of organ growth", "Positive regulation of organelle assembly", "Positive regulation of organelle organization", "Positive regulation of organic acid transport", "Positive regulation of ossification", "Positive regulation of osteoblast differentiation", "Positive regulation of oxidative stress induced cell death", "Positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Positive regulation of oxidative stress induced neuron death", "Positive regulation of oxidoreductase activity", "Positive regulation of p38mapk cascade", "Positive regulation of pathway restricted smad protein phosphorylation", "Positive regulation of pattern recognition receptor signaling pathway", "Positive regulation of peptidase activity", "Positive regulation of peptide secretion", "Positive regulation of peptidyl lysine acetylation", "Positive regulation of peptidyl serine phosphorylation", "Positive regulation of peptidyl threonine phosphorylation", "Positive regulation of peptidyl tyrosine phosphorylation", "Positive regulation of phagocytosis", "Positive regulation of phosphatase activity", "Positive regulation of phosphatidylinositol 3 kinase signaling", "Positive regulation of phospholipase a2 activity", "Positive regulation of phospholipase activity", "Positive regulation of phospholipid biosynthetic process", "Positive regulation of phospholipid metabolic process", "Positive regulation of phosphoprotein phosphatase activity", "Positive regulation of phosphorus metabolic process", "Positive regulation of pinocytosis", "Positive regulation of plasma membrane bounded cell projection assembly", "Positive regulation of plasminogen activation", "Positive regulation of platelet aggregation", "Positive regulation of podosome assembly", "Positive regulation of posttranscriptional gene silencing", "Positive regulation of potassium ion import across plasma membrane", "Positive regulation of potassium ion transmembrane transporter activity", "Positive regulation of potassium ion transport", "Positive regulation of production of mirnas involved in gene silencing by mirna", "Positive regulation of production of molecular mediator of immune response", "Positive regulation of programmed necrotic cell death", "Positive regulation of prostaglandin biosynthetic process", "Positive regulation of proteasomal ubiquitin dependent protein catabolic process", "Positive regulation of protein acetylation", "Positive regulation of protein autophosphorylation", "Positive regulation of protein binding", "Positive regulation of protein catabolic process", "Positive regulation of protein containing complex assembly", "Positive regulation of protein containing complex disassembly", "Positive regulation of protein deacetylation", "Positive regulation of protein dephosphorylation", "Positive regulation of protein depolymerization", "Positive regulation of protein deubiquitination", "Positive regulation of protein exit from endoplasmic reticulum", "Positive regulation of protein export from nucleus", "Positive regulation of protein glycosylation", "Positive regulation of protein import", "Positive regulation of protein k63 linked ubiquitination", "Positive regulation of protein kinase a signaling", "Positive regulation of protein kinase activity", "Positive regulation of protein kinase b signaling", "Positive regulation of protein localization", "Positive regulation of protein localization to cell cortex", "Positive regulation of protein localization to cell periphery", "Positive regulation of protein localization to cell surface", "Positive regulation of protein localization to centrosome", "Positive regulation of protein localization to cilium", "Positive regulation of protein localization to early endosome", "Positive regulation of protein localization to membrane", "Positive regulation of protein localization to nucleus", "Positive regulation of protein maturation", "Positive regulation of protein metabolic process", "Positive regulation of protein modification by small protein conjugation or removal", "Positive regulation of protein modification process", "Positive regulation of protein monoubiquitination", "Positive regulation of protein phosphorylation", "Positive regulation of protein polymerization", "Positive regulation of protein polyubiquitination", "Positive regulation of protein secretion", "Positive regulation of protein serine threonine kinase activity", "Positive regulation of protein sumoylation", "Positive regulation of protein targeting to membrane", "Positive regulation of protein tyrosine kinase activity", "Positive regulation of proteolysis", "Positive regulation of proteolysis involved in cellular protein catabolic process", "Positive regulation of pseudopodium assembly", "Positive regulation of reactive oxygen species biosynthetic process", "Positive regulation of reactive oxygen species metabolic process", "Positive regulation of receptor binding", "Positive regulation of receptor catabolic process", "Positive regulation of receptor clustering", "Positive regulation of receptor internalization", "Positive regulation of receptor mediated endocytosis", "Positive regulation of receptor recycling", "Positive regulation of receptor signaling pathway via stat", "Positive regulation of regulated secretory pathway", "Positive regulation of release of cytochrome c from mitochondria", "Positive regulation of release of sequestered calcium ion into cytosol", "Positive regulation of renal sodium excretion", "Positive regulation of reproductive process", "Positive regulation of respiratory burst", "Positive regulation of response to biotic stimulus", "Positive regulation of response to cytokine stimulus", "Positive regulation of response to dna damage stimulus", "Positive regulation of response to endoplasmic reticulum stress", "Positive regulation of response to external stimulus", "Positive regulation of response to oxidative stress", "Positive regulation of response to reactive oxygen species", "Positive regulation of response to tumor cell", "Positive regulation of response to wounding", "Positive regulation of retinoic acid receptor signaling pathway", "Positive regulation of rho protein signal transduction", "Positive regulation of rig i signaling pathway", "Positive regulation of rna binding", "Positive regulation of rna export from nucleus", "Positive regulation of rna metabolic process", "Positive regulation of rna polymerase ii transcription preinitiation complex assembly", "Positive regulation of rna splicing", "Positive regulation of rrna processing", "Positive regulation of ruffle assembly", "Positive regulation of ryanodine sensitive calcium release channel activity", "Positive regulation of secretion", "Positive regulation of sequestering of calcium ion", "Positive regulation of sequestering of triglyceride", "Positive regulation of signal transduction by p53 class mediator", "Positive regulation of signaling", "Positive regulation of signaling receptor activity", "Positive regulation of sister chromatid cohesion", "Positive regulation of skeletal muscle tissue development", "Positive regulation of smad protein signal transduction", "Positive regulation of small gtpase mediated signal transduction", "Positive regulation of small molecule metabolic process", "Positive regulation of smooth muscle cell apoptotic process", "Positive regulation of smooth muscle cell differentiation", "Positive regulation of smooth muscle cell migration", "Positive regulation of smooth muscle cell proliferation", "Positive regulation of smooth muscle contraction", "Positive regulation of smoothened signaling pathway", "Positive regulation of sodium ion transmembrane transport", "Positive regulation of sodium ion transmembrane transporter activity", "Positive regulation of sodium ion transport", "Positive regulation of spindle assembly", "Positive regulation of sprouting angiogenesis", "Positive regulation of stem cell differentiation", "Positive regulation of stem cell proliferation", "Positive regulation of steroid biosynthetic process", "Positive regulation of steroid hormone biosynthetic process", "Positive regulation of steroid metabolic process", "Positive regulation of sterol transport", "Positive regulation of stress activated protein kinase signaling cascade", "Positive regulation of stress fiber assembly", "Positive regulation of striated muscle cell apoptotic process", "Positive regulation of striated muscle cell differentiation", "Positive regulation of striated muscle contraction", "Positive regulation of substrate adhesion dependent cell spreading", "Positive regulation of supramolecular fiber organization", "Positive regulation of synapse assembly", "Positive regulation of synaptic plasticity", "Positive regulation of synaptic transmission", "Positive regulation of synaptic transmission gabaergic", "Positive regulation of synaptic transmission glutamatergic", "Positive regulation of synaptic vesicle endocytosis", "Positive regulation of synaptic vesicle exocytosis", "Positive regulation of synaptic vesicle recycling", "Positive regulation of syncytium formation by plasma membrane fusion", "Positive regulation of systemic arterial blood pressure", "Positive regulation of t cell apoptotic process", "Positive regulation of t cell cytokine production", "Positive regulation of t cell mediated cytotoxicity", "Positive regulation of t cell mediated immune response to tumor cell", "Positive regulation of t cell mediated immunity", "Positive regulation of t cell migration", "Positive regulation of t cell proliferation", "Positive regulation of t cell receptor signaling pathway", "Positive regulation of t cell tolerance induction", "Positive regulation of t helper 1 cell differentiation", "Positive regulation of t helper cell differentiation", "Positive regulation of tau protein kinase activity", "Positive regulation of telomerase activity", "Positive regulation of telomerase rna localization to cajal body", "Positive regulation of telomere capping", "Positive regulation of telomere maintenance", "Positive regulation of telomere maintenance via telomere lengthening", "Positive regulation of tissue remodeling", "Positive regulation of tolerance induction", "Positive regulation of toll like receptor 3 signaling pathway", "Positive regulation of toll like receptor 9 signaling pathway", "Positive regulation of toll like receptor signaling pathway", "Positive regulation of tor signaling", "Positive regulation of torc1 signaling", "Positive regulation of transcription by rna polymerase i", "Positive regulation of transcription by rna polymerase ii", "Positive regulation of transcription by rna polymerase iii", "Positive regulation of transcription elongation from rna polymerase ii promoter", "Positive regulation of transcription from rna polymerase ii promoter in response to endoplasmic reticulum stress", "Positive regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Positive regulation of transcription from rna polymerase ii promoter in response to stress", "Positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus", "Positive regulation of transcription of notch receptor target", "Positive regulation of transcription of nucleolar large rrna by rna polymerase i", "Positive regulation of transcription regulatory region dna binding", "Positive regulation of transferase activity", "Positive regulation of translation", "Positive regulation of translation in response to endoplasmic reticulum stress", "Positive regulation of translation in response to stress", "Positive regulation of translational initiation", "Positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Positive regulation of transmembrane transport", "Positive regulation of transmission of nerve impulse", "Positive regulation of transport", "Positive regulation of transporter activity", "Positive regulation of triglyceride biosynthetic process", "Positive regulation of triglyceride metabolic process", "Positive regulation of trophoblast cell migration", "Positive regulation of tumor necrosis factor mediated signaling pathway", "Positive regulation of tumor necrosis factor superfamily cytokine production", "Positive regulation of type i interferon mediated signaling pathway", "Positive regulation of type i interferon production", "Positive regulation of tyrosine phosphorylation of stat protein", "Positive regulation of ubiquitin dependent protein catabolic process", "Positive regulation of ubiquitin protein ligase activity", "Positive regulation of ubiquitin protein transferase activity", "Positive regulation of unsaturated fatty acid biosynthetic process", "Positive regulation of urine volume", "Positive regulation of vacuole organization", "Positive regulation of vascular associated smooth muscle cell apoptotic process", "Positive regulation of vascular associated smooth muscle cell differentiation", "Positive regulation of vascular associated smooth muscle cell migration", "Positive regulation of vascular associated smooth muscle cell proliferation", "Positive regulation of vascular endothelial cell proliferation", "Positive regulation of vascular endothelial growth factor production", "Positive regulation of vascular endothelial growth factor signaling pathway", "Positive regulation of vascular permeability", "Positive regulation of vasculature development", "Positive regulation of vasculogenesis", "Positive regulation of vasoconstriction", "Positive regulation of vesicle fusion", "Positive regulation of viral genome replication", "Positive regulation of viral life cycle", "Positive regulation of viral process", "Positive regulation of vitamin d receptor signaling pathway", "Positive regulation of voltage gated calcium channel activity", "Positive regulation of wnt signaling pathway", "Positive regulation of wound healing", "Positive regulation of wound healing spreading of epidermal cells", "Positive t cell selection", "Post anal tail morphogenesis", "Post chaperonin tubulin folding pathway", "Post embryonic development", "Post golgi vesicle mediated transport", "Post translational protein modification", "Postreplication repair", "Postsynapse organization", "Postsynapse to nucleus signaling pathway", "Postsynaptic actin cytoskeleton organization", "Postsynaptic cytoskeleton organization", "Postsynaptic membrane organization", "Postsynaptic modulation of chemical synaptic transmission", "Postsynaptic neurotransmitter receptor internalization", "Postsynaptic signal transduction", "Postsynaptic specialization organization", "Posttranscriptional regulation of gene expression", "Posttranslational protein targeting to endoplasmic reticulum membrane", "Posttranslational protein targeting to membrane translocation", "Potassium ion homeostasis", "Potassium ion import across plasma membrane", "Potassium ion transport", "Pre mirna processing", "Prenylation", "Presynapse organization", "Presynaptic active zone organization", "Presynaptic endocytosis", "Presynaptic modulation of chemical synaptic transmission", "Prevention of polyspermy", "Primary alcohol biosynthetic process", "Primary alcohol catabolic process", "Primary alcohol metabolic process", "Primary amino compound biosynthetic process", "Primary amino compound metabolic process", "Primary mirna processing", "Pro b cell differentiation", "Process utilizing autophagic mechanism", "Production of molecular mediator involved in inflammatory response", "Production of molecular mediator of immune response", "Production of sirna involved in rna interference", "Progesterone biosynthetic process", "Progesterone metabolic process", "Progesterone receptor signaling pathway", "Programmed cell death", "Programmed cell death in response to reactive oxygen species", "Programmed cell death involved in cell development", "Programmed necrotic cell death", "Prolactin secretion", "Proline metabolic process", "Proline transport", "Pronephros development", "Proprioception", "Prostaglandin transport", "Prostanoid biosynthetic process", "Prostanoid metabolic process", "Prostate gland development", "Prostate gland growth", "Proteasomal protein catabolic process", "Proteasome assembly", "Proteasome mediated ubiquitin dependent protein catabolic process", "Protection from natural killer cell mediated cytotoxicity", "Protection from non homologous end joining at telomere", "Protein acetylation", "Protein activation cascade", "Protein acylation", "Protein adp ribosylation", "Protein auto adp ribosylation", "Protein autophosphorylation", "Protein autoprocessing", "Protein autoubiquitination", "Protein catabolic process", "Protein catabolic process in the vacuole", "Protein complex oligomerization", "Protein containing complex disassembly", "Protein containing complex localization", "Protein containing complex organization", "Protein containing complex remodeling", "Protein de adp ribosylation", "Protein deglycosylation", "Protein demannosylation", "Protein demethylation", "Protein deneddylation", "Protein depalmitoylation", "Protein dephosphorylation", "Protein depolymerization", "Protein destabilization", "Protein desumoylation", "Protein deubiquitination involved in ubiquitin dependent protein catabolic process", "Protein dna complex assembly", "Protein dna complex disassembly", "Protein dna complex subunit organization", "Protein dna covalent cross linking repair", "Protein exit from endoplasmic reticulum", "Protein export from nucleus", "Protein folding", "Protein folding in endoplasmic reticulum", "Protein geranylgeranylation", "Protein heterooligomerization", "Protein heterotetramerization", "Protein hexamerization", "Protein homooligomerization", "Protein homotetramerization", "Protein hydroxylation", "Protein import", "Protein import into mitochondrial matrix", "Protein import into peroxisome matrix", "Protein insertion into er membrane", "Protein insertion into er membrane by stop transfer membrane anchor sequence", "Protein insertion into membrane", "Protein insertion into mitochondrial inner membrane", "Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway", "Protein k11 linked ubiquitination", "Protein k27 linked ubiquitination", "Protein k29 linked ubiquitination", "Protein k48 linked deubiquitination", "Protein k48 linked ubiquitination", "Protein k6 linked ubiquitination", "Protein k63 linked deubiquitination", "Protein k63 linked ubiquitination", "Protein kinase a signaling", "Protein kinase b signaling", "Protein kinase c signaling", "Protein lipid complex assembly", "Protein lipid complex subunit organization", "Protein localization to adherens junction", "Protein localization to axon", "Protein localization to basolateral plasma membrane", "Protein localization to cell cell junction", "Protein localization to cell cortex", "Protein localization to cell junction", "Protein localization to cell periphery", "Protein localization to cell surface", "Protein localization to chromatin", "Protein localization to chromosome", "Protein localization to chromosome centromeric region", "Protein localization to chromosome telomeric region", "Protein localization to ciliary membrane", "Protein localization to cilium", "Protein localization to condensed chromosome", "Protein localization to cytoplasmic stress granule", "Protein localization to cytoskeleton", "Protein localization to early endosome", "Protein localization to endoplasmic reticulum", "Protein localization to endoplasmic reticulum exit site", "Protein localization to endosome", "Protein localization to extracellular region", "Protein localization to golgi apparatus", "Protein localization to lysosome", "Protein localization to membrane raft", "Protein localization to microtubule", "Protein localization to microtubule end", "Protein localization to microtubule organizing center", "Protein localization to mitochondrion", "Protein localization to non motile cilium", "Protein localization to nuclear body", "Protein localization to nuclear envelope", "Protein localization to nucleolus", "Protein localization to nucleoplasm", "Protein localization to nucleus", "Protein localization to organelle", "Protein localization to perinuclear region of cytoplasm", "Protein localization to phagophore assembly site", "Protein localization to plasma membrane", "Protein localization to postsynapse", "Protein localization to presynapse", "Protein localization to synapse", "Protein localization to vacuole", "Protein mannosylation", "Protein maturation", "Protein maturation by 4fe 4s cluster transfer", "Protein maturation by iron sulfur cluster transfer", "Protein maturation by protein folding", "Protein methylation", "Protein modification by small protein conjugation", "Protein modification by small protein conjugation or removal", "Protein modification by small protein removal", "Protein monoubiquitination", "Protein n linked glycosylation", "Protein neddylation", "Protein nitrosylation", "Protein o linked glycosylation", "Protein o linked glycosylation via serine", "Protein o linked glycosylation via threonine", "Protein o linked mannosylation", "Protein oxidation", "Protein palmitoylation", "Protein peptidyl prolyl isomerization", "Protein poly adp ribosylation", "Protein polyglutamylation", "Protein polymerization", "Protein polyubiquitination", "Protein polyufmylation", "Protein processing", "Protein processing involved in protein targeting to mitochondrion", "Protein quality control for misfolded or incompletely synthesized proteins", "Protein refolding", "Protein repair", "Protein retention in er lumen", "Protein retention in golgi apparatus", "Protein stabilization", "Protein sumoylation", "Protein targeting", "Protein targeting to lysosome", "Protein targeting to membrane", "Protein targeting to mitochondrion", "Protein targeting to peroxisome", "Protein targeting to vacuole", "Protein tetramerization", "Protein transmembrane import into intracellular organelle", "Protein transmembrane transport", "Protein transport along microtubule", "Protein transport within lipid bilayer", "Protein trimerization", "Protein ufmylation", "Proteoglycan biosynthetic process", "Proteoglycan metabolic process", "Proteolysis", "Proton transmembrane transport", "Protoporphyrinogen ix biosynthetic process", "Protoporphyrinogen ix metabolic process", "Proximal distal pattern formation", "Proximal tubule development", "Pseudopodium organization", "Pseudouridine synthesis", "Pteridine containing compound biosynthetic process", "Pteridine containing compound metabolic process", "Pulmonary artery morphogenesis", "Pulmonary valve development", "Pulmonary valve morphogenesis", "Purine containing compound biosynthetic process", "Purine containing compound catabolic process", "Purine containing compound metabolic process", "Purine containing compound salvage", "Purine containing compound transmembrane transport", "Purine deoxyribonucleoside metabolic process", "Purine deoxyribonucleoside monophosphate catabolic process", "Purine deoxyribonucleoside monophosphate metabolic process", "Purine deoxyribonucleoside triphosphate metabolic process", "Purine deoxyribonucleotide biosynthetic process", "Purine deoxyribonucleotide catabolic process", "Purine deoxyribonucleotide metabolic process", "Purine nucleobase biosynthetic process", "Purine nucleobase metabolic process", "Purine nucleoside biosynthetic process", "Purine nucleoside catabolic process", "Purine nucleoside diphosphate biosynthetic process", "Purine nucleoside diphosphate catabolic process", "Purine nucleoside metabolic process", "Purine nucleoside monophosphate biosynthetic process", "Purine nucleoside monophosphate catabolic process", "Purine nucleoside monophosphate metabolic process", "Purine nucleoside triphosphate catabolic process", "Purine nucleotide catabolic process", "Purine nucleotide salvage", "Purine nucleotide transport", "Purine ribonucleoside catabolic process", "Purine ribonucleoside metabolic process", "Purine ribonucleoside salvage", "Purine ribonucleotide salvage", "Purinergic nucleotide receptor signaling pathway", "Pyramidal neuron development", "Pyramidal neuron differentiation", "Pyridine containing compound biosynthetic process", "Pyridine containing compound catabolic process", "Pyridine containing compound metabolic process", "Pyridine nucleotide biosynthetic process", "Pyridine nucleotide metabolic process", "Pyrimidine containing compound biosynthetic process", "Pyrimidine containing compound catabolic process", "Pyrimidine containing compound metabolic process", "Pyrimidine containing compound transmembrane transport", "Pyrimidine deoxyribonucleoside metabolic process", "Pyrimidine deoxyribonucleoside monophosphate biosynthetic process", "Pyrimidine deoxyribonucleoside monophosphate metabolic process", "Pyrimidine deoxyribonucleoside triphosphate metabolic process", "Pyrimidine deoxyribonucleotide biosynthetic process", "Pyrimidine deoxyribonucleotide metabolic process", "Pyrimidine nucleobase biosynthetic process", "Pyrimidine nucleobase catabolic process", "Pyrimidine nucleobase metabolic process", "Pyrimidine nucleoside diphosphate biosynthetic process", "Pyrimidine nucleoside diphosphate metabolic process", "Pyrimidine nucleoside metabolic process", "Pyrimidine nucleoside monophosphate biosynthetic process", "Pyrimidine nucleoside monophosphate metabolic process", "Pyrimidine nucleoside triphosphate biosynthetic process", "Pyrimidine nucleoside triphosphate metabolic process", "Pyrimidine nucleotide catabolic process", "Pyrimidine nucleotide metabolic process", "Pyrimidine ribonucleoside diphosphate metabolic process", "Pyrimidine ribonucleoside monophosphate metabolic process", "Pyrimidine ribonucleoside triphosphate biosynthetic process", "Pyrimidine ribonucleoside triphosphate metabolic process", "Pyrimidine ribonucleotide biosynthetic process", "Pyrimidine ribonucleotide metabolic process", "Pyroptosis", "Pyruvate metabolic process", "Quaternary ammonium group transport", "Quinone metabolic process", "R loop disassembly", "Rab protein signal transduction", "Rac protein signal transduction", "Radial glial cell differentiation", "Rap protein signal transduction", "Ras protein signal transduction", "Reactive nitrogen species metabolic process", "Reactive oxygen species biosynthetic process", "Reactive oxygen species metabolic process", "Receptor catabolic process", "Receptor clustering", "Receptor diffusion trapping", "Receptor internalization", "Receptor localization to synapse", "Receptor mediated endocytosis", "Receptor mediated endocytosis involved in cholesterol transport", "Receptor metabolic process", "Receptor recycling", "Receptor signaling pathway via stat", "Receptor transactivation", "Recognition of apoptotic cell", "Recombinational repair", "Reelin mediated signaling pathway", "Reflex", "Regeneration", "Regionalization", "Regulated exocytosis", "Regulation by virus of viral protein levels in host cell", "Regulation of 3 utr mediated mrna stabilization", "Regulation of actin cytoskeleton reorganization", "Regulation of actin filament based movement", "Regulation of actin filament based process", "Regulation of actin filament bundle assembly", "Regulation of actin filament length", "Regulation of actin filament organization", "Regulation of actin nucleation", "Regulation of action potential", "Regulation of activin receptor signaling pathway", "Regulation of actomyosin structure organization", "Regulation of acute inflammatory response", "Regulation of acute inflammatory response to antigenic stimulus", "Regulation of acyl coa biosynthetic process", "Regulation of adaptive immune response", "Regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Regulation of adenylate cyclase activity", "Regulation of adherens junction organization", "Regulation of aerobic respiration", "Regulation of alcohol biosynthetic process", "Regulation of alpha beta t cell activation", "Regulation of alpha beta t cell differentiation", "Regulation of alternative mrna splicing via spliceosome", "Regulation of amino acid transmembrane transport", "Regulation of amino acid transport", "Regulation of amyloid beta clearance", "Regulation of amyloid fibril formation", "Regulation of amyloid precursor protein catabolic process", "Regulation of anaphase promoting complex dependent catabolic process", "Regulation of anatomical structure morphogenesis", "Regulation of anatomical structure size", "Regulation of androgen receptor signaling pathway", "Regulation of animal organ formation", "Regulation of animal organ morphogenesis", "Regulation of anion channel activity", "Regulation of anion transmembrane transport", "Regulation of anion transport", "Regulation of anoikis", "Regulation of antigen receptor mediated signaling pathway", "Regulation of apoptotic cell clearance", "Regulation of apoptotic dna fragmentation", "Regulation of apoptotic process involved in development", "Regulation of apoptotic signaling pathway", "Regulation of appetite", "Regulation of arachidonic acid secretion", "Regulation of arp2 3 complex mediated actin nucleation", "Regulation of aspartic type endopeptidase activity involved in amyloid precursor protein catabolic process", "Regulation of aspartic type peptidase activity", "Regulation of astrocyte differentiation", "Regulation of atp biosynthetic process", "Regulation of atp dependent activity", "Regulation of atp metabolic process", "Regulation of atrial cardiac muscle cell membrane repolarization", "Regulation of attachment of spindle microtubules to kinetochore", "Regulation of autophagosome maturation", "Regulation of autophagy", "Regulation of autophagy of mitochondrion", "Regulation of autophagy of mitochondrion in response to mitochondrial depolarization", "Regulation of axon diameter", "Regulation of axon guidance", "Regulation of axonogenesis", "Regulation of b cell activation", "Regulation of b cell apoptotic process", "Regulation of b cell differentiation", "Regulation of b cell mediated immunity", "Regulation of b cell proliferation", "Regulation of barbed end actin filament capping", "Regulation of behavior", "Regulation of bicellular tight junction assembly", "Regulation of binding", "Regulation of biological process involved in symbiotic interaction", "Regulation of biomineralization", "Regulation of blood brain barrier permeability", "Regulation of blood circulation", "Regulation of blood pressure", "Regulation of bmp signaling pathway", "Regulation of body fluid levels", "Regulation of bone mineralization", "Regulation of bone remodeling", "Regulation of bone resorption", "Regulation of branching involved in lung morphogenesis", "Regulation of branching morphogenesis of a nerve", "Regulation of brown fat cell differentiation", "Regulation of calcineurin mediated signaling", "Regulation of calcium ion dependent exocytosis", "Regulation of calcium ion export across plasma membrane", "Regulation of calcium ion import", "Regulation of calcium ion transmembrane transport", "Regulation of calcium ion transmembrane transporter activity", "Regulation of calcium ion transport", "Regulation of calcium ion transport into cytosol", "Regulation of calcium mediated signaling", "Regulation of camp dependent protein kinase activity", "Regulation of camp mediated signaling", "Regulation of canonical wnt signaling pathway", "Regulation of carbohydrate biosynthetic process", "Regulation of carbohydrate catabolic process", "Regulation of carbohydrate metabolic process", "Regulation of cardiac conduction", "Regulation of cardiac muscle adaptation", "Regulation of cardiac muscle cell action potential", "Regulation of cardiac muscle cell action potential involved in regulation of contraction", "Regulation of cardiac muscle cell membrane potential", "Regulation of cardiac muscle cell membrane repolarization", "Regulation of cardiac muscle cell proliferation", "Regulation of cardiac muscle contraction", "Regulation of cardiac muscle contraction by calcium ion signaling", "Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion", "Regulation of cardioblast differentiation", "Regulation of cardiocyte differentiation", "Regulation of cartilage development", "Regulation of catabolic process", "Regulation of catecholamine metabolic process", "Regulation of cation channel activity", "Regulation of cation transmembrane transport", "Regulation of caveolin mediated endocytosis", "Regulation of cd4 positive alpha beta t cell activation", "Regulation of cd4 positive alpha beta t cell differentiation", "Regulation of cd8 positive alpha beta t cell activation", "Regulation of cell activation", "Regulation of cell adhesion", "Regulation of cell adhesion mediated by integrin", "Regulation of cell aging", "Regulation of cell cell adhesion", "Regulation of cell cell adhesion mediated by cadherin", "Regulation of cell communication by electrical coupling", "Regulation of cell communication by electrical coupling involved in cardiac conduction", "Regulation of cell cycle", "Regulation of cell cycle checkpoint", "Regulation of cell cycle g1 s phase transition", "Regulation of cell cycle g2 m phase transition", "Regulation of cell cycle phase transition", "Regulation of cell cycle process", "Regulation of cell death", "Regulation of cell development", "Regulation of cell differentiation", "Regulation of cell division", "Regulation of cell growth involved in cardiac muscle cell development", "Regulation of cell junction assembly", "Regulation of cell killing", "Regulation of cell matrix adhesion", "Regulation of cell maturation", "Regulation of cell migration involved in sprouting angiogenesis", "Regulation of cell morphogenesis", "Regulation of cell morphogenesis involved in differentiation", "Regulation of cell population proliferation", "Regulation of cell projection assembly", "Regulation of cell projection organization", "Regulation of cell projection size", "Regulation of cell shape", "Regulation of cell size", "Regulation of cell substrate adhesion", "Regulation of cell substrate junction organization", "Regulation of cellular amide metabolic process", "Regulation of cellular amine metabolic process", "Regulation of cellular amino acid metabolic process", "Regulation of cellular carbohydrate catabolic process", "Regulation of cellular carbohydrate metabolic process", "Regulation of cellular component biogenesis", "Regulation of cellular component movement", "Regulation of cellular component size", "Regulation of cellular ketone metabolic process", "Regulation of cellular localization", "Regulation of cellular macromolecule biosynthetic process", "Regulation of cellular ph", "Regulation of cellular protein catabolic process", "Regulation of cellular respiration", "Regulation of cellular response to growth factor stimulus", "Regulation of cellular response to heat", "Regulation of cellular response to hypoxia", "Regulation of cellular response to insulin stimulus", "Regulation of cellular response to osmotic stress", "Regulation of cellular response to stress", "Regulation of cellular response to transforming growth factor beta stimulus", "Regulation of cellular response to vascular endothelial growth factor stimulus", "Regulation of centriole replication", "Regulation of centrosome cycle", "Regulation of chaperone mediated autophagy", "Regulation of chemokine mediated signaling pathway", "Regulation of chemotaxis", "Regulation of chloride transport", "Regulation of cholesterol biosynthetic process", "Regulation of cholesterol efflux", "Regulation of cholesterol esterification", "Regulation of cholesterol metabolic process", "Regulation of chondrocyte differentiation", "Regulation of chromatin assembly", "Regulation of chromatin assembly or disassembly", "Regulation of chromatin binding", "Regulation of chromatin organization", "Regulation of chromosome condensation", "Regulation of chromosome organization", "Regulation of chromosome segregation", "Regulation of chromosome separation", "Regulation of cilium assembly", "Regulation of cilium beat frequency", "Regulation of cilium beat frequency involved in ciliary motility", "Regulation of cilium dependent cell motility", "Regulation of cilium movement", "Regulation of circadian rhythm", "Regulation of clathrin dependent endocytosis", "Regulation of coagulation", "Regulation of collagen fibril organization", "Regulation of collagen metabolic process", "Regulation of collateral sprouting", "Regulation of complement activation", "Regulation of complement dependent cytotoxicity", "Regulation of connective tissue replacement", "Regulation of core promoter binding", "Regulation of cyclase activity", "Regulation of cyclic nucleotide phosphodiesterase activity", "Regulation of cyclin dependent protein kinase activity", "Regulation of cysteine type endopeptidase activity", "Regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis", "Regulation of cytokinesis", "Regulation of cytoplasmic mrna processing body assembly", "Regulation of cytoplasmic translation", "Regulation of cytoplasmic translational elongation", "Regulation of cytoplasmic translational initiation", "Regulation of cytoplasmic transport", "Regulation of cytoskeleton organization", "Regulation of cytosolic calcium ion concentration", "Regulation of deacetylase activity", "Regulation of defense response", "Regulation of defense response to bacterium", "Regulation of defense response to virus", "Regulation of defense response to virus by host", "Regulation of delayed rectifier potassium channel activity", "Regulation of dendrite development", "Regulation of dendrite extension", "Regulation of dendrite morphogenesis", "Regulation of dendritic cell chemotaxis", "Regulation of dendritic cell differentiation", "Regulation of dendritic spine development", "Regulation of dendritic spine maintenance", "Regulation of dendritic spine morphogenesis", "Regulation of deoxyribonuclease activity", "Regulation of dephosphorylation", "Regulation of developmental growth", "Regulation of digestive system process", "Regulation of dna binding", "Regulation of dna binding transcription factor activity", "Regulation of dna biosynthetic process", "Regulation of dna catabolic process", "Regulation of dna damage checkpoint", "Regulation of dna damage response signal transduction by p53 class mediator", "Regulation of dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator", "Regulation of dna demethylation", "Regulation of dna dependent dna replication", "Regulation of dna dependent dna replication initiation", "Regulation of dna directed dna polymerase activity", "Regulation of dna duplex unwinding", "Regulation of dna helicase activity", "Regulation of dna ligation", "Regulation of dna metabolic process", "Regulation of dna methylation", "Regulation of dna methylation dependent heterochromatin assembly", "Regulation of dna primase activity", "Regulation of dna recombination", "Regulation of dna repair", "Regulation of dna replication", "Regulation of dna strand elongation", "Regulation of dna templated transcription elongation", "Regulation of dna templated transcription in response to stress", "Regulation of dna templated transcription initiation", "Regulation of dna topoisomerase atp hydrolyzing activity", "Regulation of dopamine receptor signaling pathway", "Regulation of dopaminergic neuron differentiation", "Regulation of double strand break repair", "Regulation of double strand break repair via homologous recombination", "Regulation of double strand break repair via nonhomologous end joining", "Regulation of early endosome to late endosome transport", "Regulation of eating behavior", "Regulation of electron transfer activity", "Regulation of embryonic development", "Regulation of endocytic recycling", "Regulation of endocytosis", "Regulation of endodeoxyribonuclease activity", "Regulation of endodermal cell differentiation", "Regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Regulation of endoplasmic reticulum tubular network organization", "Regulation of endoplasmic reticulum unfolded protein response", "Regulation of endosome to plasma membrane protein transport", "Regulation of endothelial cell chemotaxis", "Regulation of endothelial cell development", "Regulation of endothelial cell differentiation", "Regulation of endothelial cell migration", "Regulation of entry of bacterium into host cell", "Regulation of epidermal growth factor activated receptor activity", "Regulation of epidermis development", "Regulation of epithelial cell apoptotic process", "Regulation of epithelial cell differentiation", "Regulation of epithelial cell differentiation involved in kidney development", "Regulation of epithelial cell migration", "Regulation of epithelial cell proliferation involved in lung morphogenesis", "Regulation of epithelial to mesenchymal transition", "Regulation of er associated ubiquitin dependent protein catabolic process", "Regulation of er to golgi vesicle mediated transport", "Regulation of erad pathway", "Regulation of erbb signaling pathway", "Regulation of erythrocyte differentiation", "Regulation of establishment of planar polarity", "Regulation of establishment of protein localization", "Regulation of establishment of protein localization to chromosome", "Regulation of establishment of protein localization to mitochondrion", "Regulation of establishment or maintenance of cell polarity", "Regulation of excretion", "Regulation of execution phase of apoptosis", "Regulation of exit from mitosis", "Regulation of exocytosis", "Regulation of exosomal secretion", "Regulation of extent of cell growth", "Regulation of extracellular matrix assembly", "Regulation of extracellular matrix disassembly", "Regulation of extracellular matrix organization", "Regulation of extrinsic apoptotic signaling pathway", "Regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Regulation of fat cell differentiation", "Regulation of fat cell proliferation", "Regulation of fatty acid beta oxidation", "Regulation of fatty acid biosynthetic process", "Regulation of fatty acid metabolic process", "Regulation of fatty acid oxidation", "Regulation of fatty acid transport", "Regulation of fc gamma receptor signaling pathway involved in phagocytosis", "Regulation of fc receptor mediated stimulatory signaling pathway", "Regulation of feeding behavior", "Regulation of fertilization", "Regulation of fibroblast growth factor receptor signaling pathway", "Regulation of fibroblast migration", "Regulation of filopodium assembly", "Regulation of focal adhesion disassembly", "Regulation of g protein coupled receptor signaling pathway", "Regulation of g0 to g1 transition", "Regulation of gastrulation", "Regulation of gene expression by genomic imprinting", "Regulation of gene expression epigenetic", "Regulation of gene silencing by rna", "Regulation of generation of precursor metabolites and energy", "Regulation of genetic imprinting", "Regulation of germ cell proliferation", "Regulation of glial cell apoptotic process", "Regulation of glial cell differentiation", "Regulation of glial cell migration", "Regulation of glial cell proliferation", "Regulation of gliogenesis", "Regulation of glucagon secretion", "Regulation of glucan biosynthetic process", "Regulation of glucocorticoid biosynthetic process", "Regulation of glucocorticoid metabolic process", "Regulation of glucocorticoid receptor signaling pathway", "Regulation of gluconeogenesis", "Regulation of glucose import", "Regulation of glucose metabolic process", "Regulation of glucose transmembrane transport", "Regulation of glucosylceramidase activity", "Regulation of glutamate receptor clustering", "Regulation of glutamate secretion", "Regulation of glutamine family amino acid metabolic process", "Regulation of glycogen catabolic process", "Regulation of glycogen metabolic process", "Regulation of glycogen starch synthase activity", "Regulation of glycolytic process", "Regulation of glycoprotein metabolic process", "Regulation of golgi organization", "Regulation of golgi to plasma membrane protein transport", "Regulation of gonad development", "Regulation of granulocyte chemotaxis", "Regulation of granulocyte differentiation", "Regulation of growth", "Regulation of gtp binding", "Regulation of gtpase activity", "Regulation of guanyl nucleotide exchange factor activity", "Regulation of hair cycle", "Regulation of hair follicle development", "Regulation of heart contraction", "Regulation of heart growth", "Regulation of heart rate", "Regulation of heart rate by cardiac conduction", "Regulation of heart rate by chemical signal", "Regulation of helicase activity", "Regulation of hematopoietic progenitor cell differentiation", "Regulation of hematopoietic stem cell differentiation", "Regulation of hematopoietic stem cell proliferation", "Regulation of hemoglobin biosynthetic process", "Regulation of hemopoiesis", "Regulation of hepatic stellate cell activation", "Regulation of heterotypic cell cell adhesion", "Regulation of hexokinase activity", "Regulation of high voltage gated calcium channel activity", "Regulation of hippo signaling", "Regulation of histamine secretion by mast cell", "Regulation of histone deacetylase activity", "Regulation of histone deacetylation", "Regulation of histone h2b ubiquitination", "Regulation of histone h3 k14 acetylation", "Regulation of histone h3 k27 methylation", "Regulation of histone h3 k4 methylation", "Regulation of histone h3 k9 methylation", "Regulation of histone h3 k9 trimethylation", "Regulation of histone h4 acetylation", "Regulation of histone h4 k16 acetylation", "Regulation of histone methylation", "Regulation of histone modification", "Regulation of histone phosphorylation", "Regulation of histone ubiquitination", "Regulation of homotypic cell cell adhesion", "Regulation of hormone biosynthetic process", "Regulation of hormone levels", "Regulation of hormone metabolic process", "Regulation of hormone secretion", "Regulation of humoral immune response", "Regulation of hyaluronan biosynthetic process", "Regulation of hydrogen peroxide biosynthetic process", "Regulation of hydrogen peroxide mediated programmed cell death", "Regulation of hydrogen peroxide metabolic process", "Regulation of hydrolase activity", "Regulation of i kappab phosphorylation", "Regulation of icosanoid secretion", "Regulation of immune effector process", "Regulation of immune response", "Regulation of immune system process", "Regulation of immunoglobulin production", "Regulation of inclusion body assembly", "Regulation of inflammatory response", "Regulation of inflammatory response to antigenic stimulus", "Regulation of innate immune response", "Regulation of inositol 1 4 5 trisphosphate sensitive calcium release channel activity", "Regulation of insulin like growth factor receptor signaling pathway", "Regulation of insulin receptor signaling pathway", "Regulation of insulin secretion", "Regulation of insulin secretion involved in cellular response to glucose stimulus", "Regulation of integrin activation", "Regulation of integrin mediated signaling pathway", "Regulation of interleukin 1 mediated signaling pathway", "Regulation of interleukin 6 mediated signaling pathway", "Regulation of intestinal absorption", "Regulation of intracellular estrogen receptor signaling pathway", "Regulation of intracellular lipid transport", "Regulation of intracellular protein transport", "Regulation of intracellular signal transduction", "Regulation of intracellular steroid hormone receptor signaling pathway", "Regulation of intracellular transport", "Regulation of intrinsic apoptotic signaling pathway", "Regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Regulation of inward rectifier potassium channel activity", "Regulation of ion transmembrane transport", "Regulation of ion transport", "Regulation of ire1 mediated unfolded protein response", "Regulation of isomerase activity", "Regulation of isotype switching", "Regulation of jnk cascade", "Regulation of jun kinase activity", "Regulation of keratinocyte differentiation", "Regulation of keratinocyte migration", "Regulation of keratinocyte proliferation", "Regulation of kidney development", "Regulation of l glutamate import across plasma membrane", "Regulation of lamellipodium assembly", "Regulation of lamellipodium morphogenesis", "Regulation of lamellipodium organization", "Regulation of leukocyte adhesion to vascular endothelial cell", "Regulation of leukocyte apoptotic process", "Regulation of leukocyte chemotaxis", "Regulation of leukocyte degranulation", "Regulation of leukocyte differentiation", "Regulation of leukocyte mediated cytotoxicity", "Regulation of leukocyte mediated immunity", "Regulation of leukocyte migration", "Regulation of leukocyte proliferation", "Regulation of ligase activity", "Regulation of lipase activity", "Regulation of lipid biosynthetic process", "Regulation of lipid catabolic process", "Regulation of lipid kinase activity", "Regulation of lipid localization", "Regulation of lipid metabolic process", "Regulation of lipid storage", "Regulation of lipid transport", "Regulation of lipophagy", "Regulation of lipopolysaccharide mediated signaling pathway", "Regulation of lipoprotein lipase activity", "Regulation of lipoprotein metabolic process", "Regulation of lipoprotein particle clearance", "Regulation of locomotion involved in locomotory behavior", "Regulation of long chain fatty acid import across plasma membrane", "Regulation of long chain fatty acid import into cell", "Regulation of long term neuronal synaptic plasticity", "Regulation of long term synaptic depression", "Regulation of long term synaptic potentiation", "Regulation of low density lipoprotein particle clearance", "Regulation of lyase activity", "Regulation of lymphangiogenesis", "Regulation of lymphocyte activation", "Regulation of lymphocyte apoptotic process", "Regulation of lymphocyte chemotaxis", "Regulation of lymphocyte differentiation", "Regulation of lymphocyte mediated immunity", "Regulation of lymphocyte migration", "Regulation of lymphoid progenitor cell differentiation", "Regulation of lysosomal lumen ph", "Regulation of lysosomal protein catabolic process", "Regulation of lysosome organization", "Regulation of macroautophagy", "Regulation of macrophage activation", "Regulation of macrophage apoptotic process", "Regulation of macrophage chemotaxis", "Regulation of macrophage differentiation", "Regulation of macrophage migration", "Regulation of maintenance of sister chromatid cohesion", "Regulation of male gonad development", "Regulation of mammary gland epithelial cell proliferation", "Regulation of map kinase activity", "Regulation of mast cell activation", "Regulation of mast cell activation involved in immune response", "Regulation of matrix metallopeptidase secretion", "Regulation of mda 5 signaling pathway", "Regulation of megakaryocyte differentiation", "Regulation of meiotic cell cycle", "Regulation of meiotic cell cycle phase transition", "Regulation of meiotic nuclear division", "Regulation of membrane depolarization", "Regulation of membrane depolarization during action potential", "Regulation of membrane depolarization during cardiac muscle cell action potential", "Regulation of membrane invagination", "Regulation of membrane lipid distribution", "Regulation of membrane permeability", "Regulation of membrane potential", "Regulation of membrane protein ectodomain proteolysis", "Regulation of membrane repolarization", "Regulation of membrane repolarization during action potential", "Regulation of membrane repolarization during cardiac muscle cell action potential", "Regulation of membrane tubulation", "Regulation of mesenchymal cell proliferation", "Regulation of mesenchymal stem cell differentiation", "Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis", "Regulation of mesoderm development", "Regulation of metal ion transport", "Regulation of metalloendopeptidase activity", "Regulation of metallopeptidase activity", "Regulation of metanephros development", "Regulation of metaphase plate congression", "Regulation of microtubule based movement", "Regulation of microtubule based process", "Regulation of microtubule binding", "Regulation of microtubule cytoskeleton organization", "Regulation of microtubule depolymerization", "Regulation of microtubule nucleation", "Regulation of microtubule polymerization", "Regulation of microtubule polymerization or depolymerization", "Regulation of microvillus assembly", "Regulation of microvillus length", "Regulation of microvillus organization", "Regulation of mirna catabolic process", "Regulation of mirna metabolic process", "Regulation of mirna transcription", "Regulation of mitochondrial atp synthesis coupled electron transport", "Regulation of mitochondrial dna replication", "Regulation of mitochondrial electron transport nadh to ubiquinone", "Regulation of mitochondrial fission", "Regulation of mitochondrial fusion", "Regulation of mitochondrial gene expression", "Regulation of mitochondrial membrane permeability", "Regulation of mitochondrial membrane permeability involved in apoptotic process", "Regulation of mitochondrial membrane potential", "Regulation of mitochondrial mrna stability", "Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Regulation of mitochondrial rna catabolic process", "Regulation of mitochondrion organization", "Regulation of mitophagy", "Regulation of mitotic cell cycle", "Regulation of mitotic cell cycle phase transition", "Regulation of mitotic cell cycle spindle assembly checkpoint", "Regulation of mitotic centrosome separation", "Regulation of mitotic cytokinesis", "Regulation of mitotic nuclear division", "Regulation of mitotic recombination", "Regulation of mitotic sister chromatid segregation", "Regulation of mitotic spindle assembly", "Regulation of modification of postsynaptic structure", "Regulation of modification of synaptic structure", "Regulation of monocyte chemotaxis", "Regulation of monocyte differentiation", "Regulation of mononuclear cell migration", "Regulation of monooxygenase activity", "Regulation of morphogenesis of a branching structure", "Regulation of morphogenesis of an epithelium", "Regulation of mrna 3 end processing", "Regulation of mrna binding", "Regulation of mrna catabolic process", "Regulation of mrna export from nucleus", "Regulation of mrna metabolic process", "Regulation of mrna polyadenylation", "Regulation of mrna processing", "Regulation of mrna splicing via spliceosome", "Regulation of multicellular organism growth", "Regulation of multicellular organismal development", "Regulation of muscle adaptation", "Regulation of muscle cell differentiation", "Regulation of muscle contraction", "Regulation of muscle hypertrophy", "Regulation of muscle organ development", "Regulation of muscle system process", "Regulation of myelination", "Regulation of myeloid cell apoptotic process", "Regulation of myeloid cell differentiation", "Regulation of myeloid leukocyte differentiation", "Regulation of myeloid leukocyte mediated immunity", "Regulation of myoblast differentiation", "Regulation of myoblast fusion", "Regulation of myosin light chain phosphatase activity", "Regulation of myotube differentiation", "Regulation of nad p h oxidase activity", "Regulation of nadp metabolic process", "Regulation of natural killer cell activation", "Regulation of natural killer cell mediated immune response to tumor cell", "Regulation of natural killer cell mediated immunity", "Regulation of necrotic cell death", "Regulation of nervous system development", "Regulation of nervous system process", "Regulation of neural precursor cell proliferation", "Regulation of neuroblast proliferation", "Regulation of neurogenesis", "Regulation of neuromuscular junction development", "Regulation of neuron differentiation", "Regulation of neuron migration", "Regulation of neuron projection arborization", "Regulation of neuron projection development", "Regulation of neuron projection regeneration", "Regulation of neuronal action potential", "Regulation of neuronal synaptic plasticity", "Regulation of neurotransmitter levels", "Regulation of neurotransmitter receptor activity", "Regulation of neurotransmitter transport", "Regulation of neurotransmitter uptake", "Regulation of neurotrophin trk receptor signaling pathway", "Regulation of neutrophil chemotaxis", "Regulation of neutrophil migration", "Regulation of nik nf kappab signaling", "Regulation of nitric oxide mediated signal transduction", "Regulation of nitric oxide metabolic process", "Regulation of nitric oxide synthase activity", "Regulation of nk t cell activation", "Regulation of nk t cell differentiation", "Regulation of nmda receptor activity", "Regulation of non motile cilium assembly", "Regulation of notch signaling pathway", "Regulation of nuclear cell cycle dna replication", "Regulation of nuclear division", "Regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Regulation of nuclear transcribed mrna poly a tail shortening", "Regulation of nuclease activity", "Regulation of nucleobase containing compound transport", "Regulation of nucleocytoplasmic transport", "Regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Regulation of nucleotide binding oligomerization domain containing signaling pathway", "Regulation of nucleotide biosynthetic process", "Regulation of nucleotide metabolic process", "Regulation of oligodendrocyte differentiation", "Regulation of oocyte maturation", "Regulation of organ growth", "Regulation of organelle assembly", "Regulation of organelle organization", "Regulation of organelle transport along microtubule", "Regulation of organic acid transport", "Regulation of ossification", "Regulation of osteoblast differentiation", "Regulation of osteoblast proliferation", "Regulation of osteoclast differentiation", "Regulation of oxidative phosphorylation", "Regulation of oxidative stress induced cell death", "Regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Regulation of oxidoreductase activity", "Regulation of p38mapk cascade", "Regulation of pattern recognition receptor signaling pathway", "Regulation of peptidase activity", "Regulation of peptide transport", "Regulation of peptidyl cysteine s nitrosylation", "Regulation of peptidyl lysine acetylation", "Regulation of peptidyl serine phosphorylation", "Regulation of peptidyl serine phosphorylation of stat protein", "Regulation of peptidyl threonine phosphorylation", "Regulation of peptidyl tyrosine phosphorylation", "Regulation of perk mediated unfolded protein response", "Regulation of ph", "Regulation of phagocytosis", "Regulation of phenotypic switching", "Regulation of phosphatase activity", "Regulation of phosphatidylcholine biosynthetic process", "Regulation of phosphatidylcholine metabolic process", "Regulation of phosphatidylinositol 3 kinase activity", "Regulation of phosphatidylinositol 3 kinase signaling", "Regulation of phospholipase a2 activity", "Regulation of phospholipase activity", "Regulation of phospholipase c activity", "Regulation of phospholipid biosynthetic process", "Regulation of phospholipid catabolic process", "Regulation of phospholipid metabolic process", "Regulation of phosphoprotein phosphatase activity", "Regulation of phosphorus metabolic process", "Regulation of pigmentation", "Regulation of pinocytosis", "Regulation of plasma lipoprotein particle levels", "Regulation of plasma membrane organization", "Regulation of plasminogen activation", "Regulation of platelet activation", "Regulation of platelet aggregation", "Regulation of platelet derived growth factor receptor signaling pathway", "Regulation of podosome assembly", "Regulation of polysaccharide metabolic process", "Regulation of positive chemotaxis", "Regulation of post translational protein modification", "Regulation of postsynapse organization", "Regulation of postsynaptic cytosolic calcium ion concentration", "Regulation of postsynaptic membrane neurotransmitter receptor levels", "Regulation of postsynaptic membrane potential", "Regulation of postsynaptic neurotransmitter receptor internalization", "Regulation of potassium ion import", "Regulation of potassium ion transmembrane transporter activity", "Regulation of potassium ion transport", "Regulation of presynapse organization", "Regulation of presynaptic cytosolic calcium ion concentration", "Regulation of pro b cell differentiation", "Regulation of production of molecular mediator of immune response", "Regulation of production of small rna involved in gene silencing by rna", "Regulation of programmed necrotic cell death", "Regulation of prostaglandin secretion", "Regulation of proteasomal protein catabolic process", "Regulation of proteasomal ubiquitin dependent protein catabolic process", "Regulation of protein acetylation", "Regulation of protein adp ribosylation", "Regulation of protein autophosphorylation", "Regulation of protein autoubiquitination", "Regulation of protein binding", "Regulation of protein catabolic process", "Regulation of protein catabolic process in the vacuole", "Regulation of protein complex stability", "Regulation of protein containing complex assembly", "Regulation of protein containing complex disassembly", "Regulation of protein deacetylation", "Regulation of protein dephosphorylation", "Regulation of protein depolymerization", "Regulation of protein deubiquitination", "Regulation of protein exit from endoplasmic reticulum", "Regulation of protein export from nucleus", "Regulation of protein folding", "Regulation of protein glycosylation", "Regulation of protein import", "Regulation of protein k63 linked ubiquitination", "Regulation of protein kinase a signaling", "Regulation of protein kinase activity", "Regulation of protein kinase c signaling", "Regulation of protein lipidation", "Regulation of protein localization", "Regulation of protein localization to cell cortex", "Regulation of protein localization to cell periphery", "Regulation of protein localization to cell surface", "Regulation of protein localization to centrosome", "Regulation of protein localization to chromatin", "Regulation of protein localization to chromosome telomeric region", "Regulation of protein localization to cilium", "Regulation of protein localization to endosome", "Regulation of protein localization to membrane", "Regulation of protein localization to nucleolus", "Regulation of protein localization to nucleus", "Regulation of protein localization to plasma membrane", "Regulation of protein localization to synapse", "Regulation of protein maturation", "Regulation of protein modification by small protein conjugation or removal", "Regulation of protein modification process", "Regulation of protein monoubiquitination", "Regulation of protein neddylation", "Regulation of protein phosphorylation", "Regulation of protein polymerization", "Regulation of protein polyubiquitination", "Regulation of protein secretion", "Regulation of protein serine threonine kinase activity", "Regulation of protein stability", "Regulation of protein sumoylation", "Regulation of protein targeting", "Regulation of protein targeting to membrane", "Regulation of protein tyrosine kinase activity", "Regulation of protein tyrosine phosphatase activity", "Regulation of proteolysis", "Regulation of proton transport", "Regulation of rac protein signal transduction", "Regulation of ras protein signal transduction", "Regulation of reactive oxygen species biosynthetic process", "Regulation of reactive oxygen species metabolic process", "Regulation of receptor binding", "Regulation of receptor catabolic process", "Regulation of receptor clustering", "Regulation of receptor internalization", "Regulation of receptor localization to synapse", "Regulation of receptor mediated endocytosis", "Regulation of receptor mediated endocytosis involved in cholesterol transport", "Regulation of receptor recycling", "Regulation of receptor signaling pathway via stat", "Regulation of regulated secretory pathway", "Regulation of relaxation of cardiac muscle", "Regulation of relaxation of muscle", "Regulation of release of cytochrome c from mitochondria", "Regulation of release of sequestered calcium ion into cytosol", "Regulation of removal of superoxide radicals", "Regulation of renal system process", "Regulation of reproductive process", "Regulation of respiratory burst", "Regulation of respiratory gaseous exchange", "Regulation of respiratory gaseous exchange by nervous system process", "Regulation of respiratory system process", "Regulation of response to biotic stimulus", "Regulation of response to cytokine stimulus", "Regulation of response to dna damage stimulus", "Regulation of response to endoplasmic reticulum stress", "Regulation of response to external stimulus", "Regulation of response to extracellular stimulus", "Regulation of response to food", "Regulation of response to interferon gamma", "Regulation of response to osmotic stress", "Regulation of response to oxidative stress", "Regulation of response to reactive oxygen species", "Regulation of response to stress", "Regulation of response to tumor cell", "Regulation of response to wounding", "Regulation of retinal ganglion cell axon guidance", "Regulation of retinoic acid receptor signaling pathway", "Regulation of retrograde protein transport er to cytosol", "Regulation of retrograde transport endosome to golgi", "Regulation of rho dependent protein serine threonine kinase activity", "Regulation of rho protein signal transduction", "Regulation of rhodopsin mediated signaling pathway", "Regulation of ribonuclease activity", "Regulation of ribosome biogenesis", "Regulation of rig i signaling pathway", "Regulation of rna binding", "Regulation of rna export from nucleus", "Regulation of rna polymerase ii regulatory region sequence specific dna binding", "Regulation of rna polymerase ii transcription preinitiation complex assembly", "Regulation of rna splicing", "Regulation of rrna processing", "Regulation of ruffle assembly", "Regulation of ryanodine sensitive calcium release channel activity", "Regulation of sarcomere organization", "Regulation of secondary heart field cardioblast proliferation", "Regulation of secretion", "Regulation of sequestering of triglyceride", "Regulation of sequestering of zinc ion", "Regulation of short term neuronal synaptic plasticity", "Regulation of signal transduction by p53 class mediator", "Regulation of signaling receptor activity", "Regulation of sister chromatid cohesion", "Regulation of skeletal muscle adaptation", "Regulation of skeletal muscle cell differentiation", "Regulation of skeletal muscle contraction", "Regulation of skeletal muscle contraction by calcium ion signaling", "Regulation of skeletal muscle tissue development", "Regulation of smad protein complex assembly", "Regulation of smad protein signal transduction", "Regulation of small gtpase mediated signal transduction", "Regulation of small molecule metabolic process", "Regulation of smooth muscle cell chemotaxis", "Regulation of smooth muscle cell differentiation", "Regulation of smooth muscle contraction", "Regulation of smoothened signaling pathway", "Regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Regulation of snrna transcription by rna polymerase ii", "Regulation of sodium ion transmembrane transport", "Regulation of sodium ion transport", "Regulation of sodium proton antiporter activity", "Regulation of spindle assembly", "Regulation of spindle organization", "Regulation of spontaneous synaptic transmission", "Regulation of sprouting angiogenesis", "Regulation of stem cell differentiation", "Regulation of stem cell population maintenance", "Regulation of stem cell proliferation", "Regulation of steroid biosynthetic process", "Regulation of steroid hormone biosynthetic process", "Regulation of steroid metabolic process", "Regulation of sterol transport", "Regulation of stress activated protein kinase signaling cascade", "Regulation of stress granule assembly", "Regulation of striated muscle cell differentiation", "Regulation of striated muscle contraction", "Regulation of substrate adhesion dependent cell spreading", "Regulation of sulfur metabolic process", "Regulation of superoxide anion generation", "Regulation of superoxide dismutase activity", "Regulation of superoxide metabolic process", "Regulation of supramolecular fiber organization", "Regulation of synapse assembly", "Regulation of synapse maturation", "Regulation of synapse structural plasticity", "Regulation of synapse structure or activity", "Regulation of synaptic plasticity", "Regulation of synaptic transmission dopaminergic", "Regulation of synaptic transmission gabaergic", "Regulation of synaptic transmission glutamatergic", "Regulation of synaptic vesicle endocytosis", "Regulation of synaptic vesicle exocytosis", "Regulation of synaptic vesicle priming", "Regulation of synaptic vesicle recycling", "Regulation of syncytium formation by plasma membrane fusion", "Regulation of system process", "Regulation of systemic arterial blood pressure", "Regulation of systemic arterial blood pressure by endothelin", "Regulation of systemic arterial blood pressure by hormone", "Regulation of systemic arterial blood pressure by renin angiotensin", "Regulation of systemic arterial blood pressure mediated by a chemical signal", "Regulation of t cell activation", "Regulation of t cell apoptotic process", "Regulation of t cell chemotaxis", "Regulation of t cell differentiation", "Regulation of t cell differentiation in thymus", "Regulation of t cell mediated cytotoxicity", "Regulation of t cell mediated immune response to tumor cell", "Regulation of t cell mediated immunity", "Regulation of t cell migration", "Regulation of t cell proliferation", "Regulation of t cell receptor signaling pathway", "Regulation of t circle formation", "Regulation of t helper 1 cell differentiation", "Regulation of t helper 1 type immune response", "Regulation of t helper 2 cell differentiation", "Regulation of t helper cell differentiation", "Regulation of tau protein kinase activity", "Regulation of telomerase activity", "Regulation of telomere capping", "Regulation of telomere maintenance", "Regulation of telomere maintenance via telomere lengthening", "Regulation of tetrapyrrole metabolic process", "Regulation of the force of heart contraction", "Regulation of thymocyte apoptotic process", "Regulation of tissue remodeling", "Regulation of tolerance induction", "Regulation of toll like receptor 3 signaling pathway", "Regulation of toll like receptor 4 signaling pathway", "Regulation of toll like receptor 7 signaling pathway", "Regulation of toll like receptor 9 signaling pathway", "Regulation of toll like receptor signaling pathway", "Regulation of tor signaling", "Regulation of torc2 signaling", "Regulation of trail activated apoptotic signaling pathway", "Regulation of trans synaptic signaling", "Regulation of transcription by glucose", "Regulation of transcription by rna polymerase i", "Regulation of transcription by rna polymerase iii", "Regulation of transcription elongation from rna polymerase ii promoter", "Regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Regulation of transcription from rna polymerase ii promoter in response to oxidative stress", "Regulation of transcription involved in g1 s transition of mitotic cell cycle", "Regulation of transcription of nucleolar large rrna by rna polymerase i", "Regulation of transcription regulatory region dna binding", "Regulation of transferase activity", "Regulation of transforming growth factor beta activation", "Regulation of transforming growth factor beta1 production", "Regulation of translation at synapse modulating synaptic transmission", "Regulation of translation in response to endoplasmic reticulum stress", "Regulation of translation in response to stress", "Regulation of translation initiation in response to endoplasmic reticulum stress", "Regulation of translational elongation", "Regulation of translational fidelity", "Regulation of translational initiation", "Regulation of translational initiation by eif2 alpha phosphorylation", "Regulation of translational initiation in response to stress", "Regulation of translational termination", "Regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Regulation of transmembrane transport", "Regulation of transmission of nerve impulse", "Regulation of transport", "Regulation of transporter activity", "Regulation of transposition", "Regulation of triglyceride biosynthetic process", "Regulation of triglyceride metabolic process", "Regulation of tube size", "Regulation of tumor necrosis factor mediated signaling pathway", "Regulation of type b pancreatic cell development", "Regulation of type i interferon mediated signaling pathway", "Regulation of ubiquitin dependent protein catabolic process", "Regulation of ubiquitin protein ligase activity", "Regulation of ubiquitin protein transferase activity", "Regulation of ubiquitin specific protease activity", "Regulation of unsaturated fatty acid biosynthetic process", "Regulation of urine volume", "Regulation of vacuole organization", "Regulation of vascular associated smooth muscle cell differentiation", "Regulation of vascular associated smooth muscle contraction", "Regulation of vascular endothelial growth factor receptor signaling pathway", "Regulation of vascular permeability", "Regulation of vascular wound healing", "Regulation of vasculature development", "Regulation of vasculogenesis", "Regulation of vasoconstriction", "Regulation of ventricular cardiac muscle cell action potential", "Regulation of very low density lipoprotein particle clearance", "Regulation of vesicle fusion", "Regulation of vesicle mediated transport", "Regulation of vesicle size", "Regulation of viral entry into host cell", "Regulation of viral genome replication", "Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Regulation of viral process", "Regulation of viral transcription", "Regulation of vitamin d receptor signaling pathway", "Regulation of vitamin metabolic process", "Regulation of voltage gated calcium channel activity", "Regulation of water loss via skin", "Regulation of wnt signaling pathway", "Regulation of wound healing", "Regulation of wound healing spreading of epidermal cells", "Relaxation of cardiac muscle", "Relaxation of muscle", "Release of cytochrome c from mitochondria", "Release of sequestered calcium ion into cytosol by endoplasmic reticulum", "Renal absorption", "Renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure", "Renal sodium excretion", "Renal sodium ion absorption", "Renal sodium ion transport", "Renal system process", "Renal system process involved in regulation of systemic arterial blood pressure", "Renal tubular secretion", "Renal tubule development", "Renal vesicle development", "Renal vesicle formation", "Renal water homeostasis", "Replacement ossification", "Replication born double strand break repair via sister chromatid exchange", "Replication fork processing", "Replication fork protection", "Replicative senescence", "Reproduction", "Reproductive behavior", "Reproductive system development", "Rescue of stalled ribosome", "Resolution of meiotic recombination intermediates", "Resolution of recombination intermediates", "Respiratory burst", "Respiratory burst involved in defense response", "Respiratory burst involved in inflammatory response", "Respiratory chain complex iii assembly", "Respiratory chain complex iv assembly", "Respiratory electron transport chain", "Respiratory gaseous exchange by respiratory system", "Respiratory system development", "Respiratory system process", "Response to abiotic stimulus", "Response to acetylcholine", "Response to acid chemical", "Response to acidic ph", "Response to actinomycin d", "Response to activity", "Response to alcohol", "Response to aldosterone", "Response to alkaloid", "Response to amine", "Response to amino acid starvation", "Response to ammonium ion", "Response to amphetamine", "Response to amyloid beta", "Response to angiotensin", "Response to antibiotic", "Response to arsenic containing substance", "Response to arsenite ion", "Response to atp", "Response to auditory stimulus", "Response to axon injury", "Response to bacterium", "Response to bmp", "Response to cadmium ion", "Response to caffeine", "Response to calcium ion", "Response to camp", "Response to camptothecin", "Response to carbohydrate", "Response to catecholamine", "Response to cell cycle checkpoint signaling", "Response to chemokine", "Response to cisplatin", "Response to cobalt ion", "Response to cocaine", "Response to cold", "Response to copper ion", "Response to corticosteroid", "Response to corticosterone", "Response to cortisol", "Response to cytokine", "Response to dexamethasone", "Response to dietary excess", "Response to dopamine", "Response to dsrna", "Response to electrical stimulus", "Response to endogenous stimulus", "Response to endoplasmic reticulum stress", "Response to epidermal growth factor", "Response to epinephrine", "Response to estradiol", "Response to estrogen", "Response to ethanol", "Response to ether", "Response to extracellular stimulus", "Response to fatty acid", "Response to fibroblast growth factor", "Response to fluid shear stress", "Response to folic acid", "Response to follicle stimulating hormone", "Response to food", "Response to fungus", "Response to gamma radiation", "Response to glucagon", "Response to glycoside", "Response to gonadotropin", "Response to growth factor", "Response to growth hormone", "Response to heat", "Response to heparin", "Response to hepatocyte growth factor", "Response to herbicide", "Response to histamine", "Response to hormone", "Response to hydrogen peroxide", "Response to hydroperoxide", "Response to hydrostatic pressure", "Response to hydroxyurea", "Response to hyperoxia", "Response to immobilization stress", "Response to increased oxygen levels", "Response to indole 3 methanol", "Response to inorganic substance", "Response to insecticide", "Response to insulin", "Response to interferon alpha", "Response to interferon beta", "Response to interferon gamma", "Response to interleukin 1", "Response to interleukin 12", "Response to interleukin 3", "Response to interleukin 4", "Response to interleukin 6", "Response to interleukin 7", "Response to ionizing radiation", "Response to iron ii ion", "Response to iron ion", "Response to ischemia", "Response to isoquinoline alkaloid", "Response to ketone", "Response to l ascorbic acid", "Response to l glutamate", "Response to l phenylalanine derivative", "Response to lead ion", "Response to lectin", "Response to leptin", "Response to leucine", "Response to leukemia inhibitory factor", "Response to light intensity", "Response to light stimulus", "Response to lipid", "Response to lithium ion", "Response to magnesium ion", "Response to manganese ion", "Response to mechanical stimulus", "Response to mercury ion", "Response to metal ion", "Response to methylmercury", "Response to mineralocorticoid", "Response to misfolded protein", "Response to mitochondrial depolarisation", "Response to molecule of bacterial origin", "Response to monosaccharide", "Response to muramyl dipeptide", "Response to muscle activity", "Response to muscle stretch", "Response to nerve growth factor", "Response to nicotine", "Response to nitric oxide", "Response to nitrogen compound", "Response to nitrosative stress", "Response to nutrient", "Response to oleic acid", "Response to organic cyclic compound", "Response to osmotic stress", "Response to oxidative stress", "Response to oxygen containing compound", "Response to oxygen glucose deprivation", "Response to oxygen levels", "Response to oxygen radical", "Response to pain", "Response to parathyroid hormone", "Response to peptide", "Response to peptide hormone", "Response to peptidoglycan", "Response to ph", "Response to phorbol 13 acetate 12 myristate", "Response to platelet derived growth factor", "Response to potassium ion", "Response to progesterone", "Response to prostaglandin", "Response to prostaglandin e", "Response to purine containing compound", "Response to radiation", "Response to reactive oxygen species", "Response to redox state", "Response to retinoic acid", "Response to salt", "Response to salt stress", "Response to selenium ion", "Response to sodium arsenite", "Response to starvation", "Response to steroid hormone", "Response to sterol depletion", "Response to temperature stimulus", "Response to testosterone", "Response to thyroglobulin triiodothyronine", "Response to thyroid hormone", "Response to thyroxine", "Response to topologically incorrect protein", "Response to toxic substance", "Response to transforming growth factor beta", "Response to tumor cell", "Response to tumor necrosis factor", "Response to type i interferon", "Response to uv", "Response to uv a", "Response to uv b", "Response to uv c", "Response to virus", "Response to vitamin", "Response to vitamin a", "Response to vitamin d", "Response to vitamin e", "Response to vitamin k", "Response to water", "Response to wounding", "Response to x ray", "Response to xenobiotic stimulus", "Response to zinc ion", "Reticulophagy", "Retina development in camera type eye", "Retina homeostasis", "Retina layer formation", "Retina morphogenesis in camera type eye", "Retinal cell apoptotic process", "Retinal cone cell differentiation", "Retinal ganglion cell axon guidance", "Retinal metabolic process", "Retinal rod cell development", "Retinal rod cell differentiation", "Retinoic acid metabolic process", "Retinoic acid receptor signaling pathway", "Retinol metabolic process", "Retrograde axonal transport", "Retrograde transport endosome to golgi", "Retrograde transport vesicle recycling within golgi", "Retrograde vesicle mediated transport golgi to endoplasmic reticulum", "Reverse cholesterol transport", "Reversible differentiation", "Rho protein signal transduction", "Rhodopsin mediated signaling pathway", "Rhythmic behavior", "Rhythmic process", "Riboflavin metabolic process", "Ribonucleoprotein complex biogenesis", "Ribonucleoprotein complex disassembly", "Ribonucleoprotein complex localization", "Ribonucleoprotein complex subunit organization", "Ribonucleoside catabolic process", "Ribonucleoside diphosphate biosynthetic process", "Ribonucleoside diphosphate catabolic process", "Ribonucleoside diphosphate metabolic process", "Ribonucleoside metabolic process", "Ribonucleoside monophosphate biosynthetic process", "Ribonucleoside monophosphate catabolic process", "Ribonucleoside monophosphate metabolic process", "Ribonucleoside triphosphate biosynthetic process", "Ribonucleoside triphosphate metabolic process", "Ribonucleotide catabolic process", "Ribose phosphate biosynthetic process", "Ribose phosphate metabolic process", "Ribosomal large subunit assembly", "Ribosomal large subunit biogenesis", "Ribosomal large subunit export from nucleus", "Ribosomal small subunit assembly", "Ribosomal small subunit biogenesis", "Ribosomal small subunit export from nucleus", "Ribosomal subunit export from nucleus", "Ribosome assembly", "Ribosome associated ubiquitin dependent protein catabolic process", "Ribosome biogenesis", "Ribosome disassembly", "Rig i signaling pathway", "Righting reflex", "Rna 3 end processing", "Rna 5 end processing", "Rna capping", "Rna catabolic process", "Rna decapping", "Rna dependent dna biosynthetic process", "Rna destabilization", "Rna export from nucleus", "Rna guanine n7 methylation", "Rna import into mitochondrion", "Rna interference", "Rna localization", "Rna mediated gene silencing by inhibition of translation", "Rna methylation", "Rna modification", "Rna phosphodiester bond hydrolysis", "Rna phosphodiester bond hydrolysis endonucleolytic", "Rna phosphodiester bond hydrolysis exonucleolytic", "Rna polyadenylation", "Rna polymerase i preinitiation complex assembly", "Rna polymerase ii preinitiation complex assembly", "Rna processing", "Rna secondary structure unwinding", "Rna splicing", "Rna splicing via endonucleolytic cleavage and ligation", "Rna splicing via transesterification reactions", "Rna stabilization", "Rna surveillance", "Roof of mouth development", "Roundabout signaling pathway", "Rrna 3 end processing", "Rrna 5 end processing", "Rrna base methylation", "Rrna catabolic process", "Rrna metabolic process", "Rrna methylation", "Rrna modification", "Rrna pseudouridine synthesis", "Rrna transcription", "Rrna transport", "Ruffle assembly", "Ruffle organization", "S adenosylmethionine cycle", "S adenosylmethionine metabolic process", "Salivary gland development", "Sarcomere organization", "Sarcoplasmic reticulum calcium ion transport", "Satellite cell activation involved in skeletal muscle regeneration", "Scarna localization to cajal body", "Scf dependent proteasomal ubiquitin dependent protein catabolic process", "Schwann cell development", "Schwann cell differentiation", "Schwann cell proliferation", "Second messenger mediated signaling", "Secondary alcohol metabolic process", "Secondary metabolic process", "Secretion", "Secretion by tissue", "Secretory granule localization", "Secretory granule organization", "Segmentation", "Selective autophagy", "Self proteolysis", "Semaphorin plexin signaling pathway", "Semaphorin plexin signaling pathway involved in neuron projection guidance", "Semi lunar valve development", "Sensory organ development", "Sensory organ morphogenesis", "Sensory perception", "Sensory perception of light stimulus", "Sensory perception of mechanical stimulus", "Sensory perception of pain", "Sensory system development", "Septum primum development", "Sequestering of actin monomers", "Sequestering of calcium ion", "Sequestering of iron ion", "Sequestering of metal ion", "Sequestering of triglyceride", "Sequestering of zinc ion", "Serine family amino acid biosynthetic process", "Serine family amino acid catabolic process", "Serine family amino acid metabolic process", "Serine phosphorylation of stat protein", "Serine transport", "Serotonin metabolic process", "Sertoli cell development", "Sertoli cell differentiation", "Sex determination", "Sex differentiation", "Short chain fatty acid catabolic process", "Short chain fatty acid metabolic process", "Short term memory", "Signal peptide processing", "Signal release", "Signal transduction by p53 class mediator", "Signal transduction in absence of ligand", "Signal transduction in response to dna damage", "Signal transduction involved in regulation of gene expression", "Signaling receptor ligand precursor processing", "Single fertilization", "Single strand break repair", "Single stranded viral rna replication via double stranded dna intermediate", "Sister chromatid cohesion", "Sister chromatid segregation", "Skeletal muscle acetylcholine gated channel clustering", "Skeletal muscle adaptation", "Skeletal muscle cell differentiation", "Skeletal muscle cell proliferation", "Skeletal muscle contraction", "Skeletal muscle fiber differentiation", "Skeletal muscle organ development", "Skeletal muscle satellite cell activation", "Skeletal muscle tissue regeneration", "Skeletal myofibril assembly", "Skeletal system development", "Skeletal system morphogenesis", "Skin development", "Skin epidermis development", "Skin morphogenesis", "Smad protein complex assembly", "Smad protein signal transduction", "Small gtpase mediated signal transduction", "Small molecule biosynthetic process", "Small molecule catabolic process", "Small molecule metabolic process", "Small nucleolar ribonucleoprotein complex assembly", "Small rna loading onto risc", "Smooth muscle adaptation", "Smooth muscle cell apoptotic process", "Smooth muscle cell chemotaxis", "Smooth muscle cell differentiation", "Smooth muscle cell migration", "Smooth muscle cell proliferation", "Smooth muscle contraction", "Smoothened signaling pathway", "Smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Sno s rna metabolic process", "Sno s rna processing", "Snorna localization", "Snrna metabolic process", "Snrna modification", "Snrna processing", "Snrna transcription", "Snrna transcription by rna polymerase ii", "Snrna transport", "Sodium ion export across plasma membrane", "Sodium ion homeostasis", "Sodium ion import across plasma membrane", "Sodium ion transmembrane transport", "Sodium ion transport", "Somatic diversification of immune receptors", "Somatic diversification of immune receptors via somatic mutation", "Somatic diversification of immunoglobulins", "Somatic diversification of immunoglobulins involved in immune response", "Somatic diversification of t cell receptor genes", "Somatic stem cell population maintenance", "Somite development", "Somitogenesis", "Specification of animal organ identity", "Specification of symmetry", "Sperm capacitation", "Sperm dna condensation", "Sperm egg recognition", "Sperm motility", "Spermatid differentiation", "Spermatid nucleus differentiation", "Spermatogenesis exchange of chromosomal proteins", "Spermidine metabolic process", "Sphingoid metabolic process", "Sphingolipid biosynthetic process", "Sphingolipid mediated signaling pathway", "Sphingolipid metabolic process", "Sphingolipid translocation", "Sphingomyelin biosynthetic process", "Sphingomyelin catabolic process", "Sphingomyelin metabolic process", "Sphingosine biosynthetic process", "Spinal cord development", "Spinal cord motor neuron differentiation", "Spindle assembly", "Spindle elongation", "Spindle localization", "Spindle midzone assembly", "Spindle organization", "Spleen development", "Spliceosomal complex assembly", "Spliceosomal conformational changes to generate catalytic conformation", "Spliceosomal snrnp assembly", "Spliceosomal tri snrnp complex assembly", "Spontaneous synaptic transmission", "Sprouting angiogenesis", "Srp dependent cotranslational protein targeting to membrane", "Srp dependent cotranslational protein targeting to membrane signal sequence recognition", "Srp dependent cotranslational protein targeting to membrane translocation", "Startle response", "Stem cell differentiation", "Stem cell division", "Stem cell proliferation", "Steroid biosynthetic process", "Steroid catabolic process", "Steroid esterification", "Steroid hormone biosynthetic process", "Steroid hormone mediated signaling pathway", "Steroid metabolic process", "Sterol biosynthetic process", "Sterol homeostasis", "Sterol import", "Sterol metabolic process", "Sterol transport", "Stress activated protein kinase signaling cascade", "Stress fiber assembly", "Stress granule assembly", "Stress granule disassembly", "Stress induced premature senescence", "Stress response to metal ion", "Striated muscle adaptation", "Striated muscle cell apoptotic process", "Striated muscle cell development", "Striated muscle cell differentiation", "Striated muscle cell proliferation", "Striated muscle contraction", "Striatum development", "Subpallium development", "Substantia nigra development", "Substrate adhesion dependent cell spreading", "Substrate dependent cell migration", "Substrate dependent cell migration cell extension", "Substrate independent telencephalic tangential migration", "Subtelomeric heterochromatin assembly", "Succinate metabolic process", "Succinate transmembrane transport", "Succinyl coa metabolic process", "Suckling behavior", "Sugar mediated signaling pathway", "Sulfate transport", "Sulfur amino acid biosynthetic process", "Sulfur amino acid catabolic process", "Sulfur amino acid metabolic process", "Sulfur compound biosynthetic process", "Sulfur compound catabolic process", "Sulfur compound metabolic process", "Sulfur compound transport", "Superoxide anion generation", "Superoxide metabolic process", "Suppression of viral release by host", "Supramolecular fiber organization", "Sympathetic ganglion development", "Sympathetic nervous system development", "Synapse assembly", "Synapse maturation", "Synapse organization", "Synapse pruning", "Synaptic assembly at neuromuscular junction", "Synaptic signaling", "Synaptic transmission dopaminergic", "Synaptic transmission gabaergic", "Synaptic transmission glutamatergic", "Synaptic vesicle budding", "Synaptic vesicle clustering", "Synaptic vesicle cytoskeletal transport", "Synaptic vesicle docking", "Synaptic vesicle endosomal processing", "Synaptic vesicle exocytosis", "Synaptic vesicle localization", "Synaptic vesicle maturation", "Synaptic vesicle membrane organization", "Synaptic vesicle priming", "Synaptic vesicle recycling", "Synaptic vesicle recycling via endosome", "Synaptic vesicle transport", "Synaptic vesicle uncoating", "Synaptonemal complex organization", "Syncytium formation", "T cell activation", "T cell activation involved in immune response", "T cell apoptotic process", "T cell chemotaxis", "T cell cytokine production", "T cell differentiation", "T cell differentiation in thymus", "T cell differentiation involved in immune response", "T cell extravasation", "T cell homeostasis", "T cell lineage commitment", "T cell mediated cytotoxicity", "T cell mediated immune response to tumor cell", "T cell mediated immunity", "T cell migration", "T cell proliferation", "T cell proliferation involved in immune response", "T cell receptor signaling pathway", "T cell selection", "T cell tolerance induction", "T helper 1 cell differentiation", "T helper 1 type immune response", "T helper 17 cell differentiation", "T helper 17 cell lineage commitment", "T helper 17 type immune response", "T helper 2 cell differentiation", "T helper cell lineage commitment", "T tubule organization", "Tail anchored membrane protein insertion into er membrane", "Tangential migration from the subventricular zone to the olfactory bulb", "Taxis", "Telencephalon development", "Telencephalon glial cell migration", "Telencephalon regionalization", "Telomerase holoenzyme complex assembly", "Telomerase rna localization", "Telomere capping", "Telomere maintenance", "Telomere maintenance in response to dna damage", "Telomere maintenance via recombination", "Telomere maintenance via semi conservative replication", "Telomere maintenance via telomere lengthening", "Telomere organization", "Telomeric d loop disassembly", "Telomeric loop disassembly", "Temperature homeostasis", "Terminal button organization", "Termination of rna polymerase ii transcription", "Terpenoid biosynthetic process", "Terpenoid metabolic process", "Tertiary alcohol metabolic process", "Tetrahydrobiopterin metabolic process", "Tetrahydrofolate biosynthetic process", "Tetrahydrofolate interconversion", "Tetrahydrofolate metabolic process", "Tetrapyrrole biosynthetic process", "Tetrapyrrole catabolic process", "Tetrapyrrole metabolic process", "Thalamus development", "Thiamine containing compound metabolic process", "Thiamine transport", "Thioester biosynthetic process", "Thioester metabolic process", "Thorax and anterior abdomen determination", "Threonine catabolic process", "Threonine metabolic process", "Thrombin activated receptor signaling pathway", "Thrombopoietin mediated signaling pathway", "Thymocyte apoptotic process", "Thymus development", "Thyroid gland development", "Thyroid hormone mediated signaling pathway", "Tight junction organization", "Tissue development", "Tissue migration", "Tissue morphogenesis", "Tissue regeneration", "Tissue remodeling", "Tolerance induction", "Toll like receptor 3 signaling pathway", "Toll like receptor 4 signaling pathway", "Toll like receptor 7 signaling pathway", "Toll like receptor 8 signaling pathway", "Toll like receptor 9 signaling pathway", "Toll like receptor signaling pathway", "Tongue development", "Tongue morphogenesis", "Tooth mineralization", "Tor signaling", "Torc1 signaling", "Torc2 signaling", "Toxin metabolic process", "Toxin transport", "Trabecula morphogenesis", "Trachea development", "Trachea formation", "Trachea morphogenesis", "Trail activated apoptotic signaling pathway", "Trans synaptic signaling by trans synaptic complex", "Trans synaptic signaling modulating synaptic transmission", "Transcription by rna polymerase i", "Transcription by rna polymerase iii", "Transcription coupled nucleotide excision repair", "Transcription dependent tethering of rna polymerase ii gene dna at nuclear periphery", "Transcription elongation from rna polymerase i promoter", "Transcription elongation from rna polymerase ii promoter", "Transcription initiation from rna polymerase i promoter", "Transcription initiation from rna polymerase ii promoter", "Transcription initiation from rna polymerase iii promoter", "Transcription preinitiation complex assembly", "Transcytosis", "Transdifferentiation", "Transepithelial chloride transport", "Transepithelial transport", "Transferrin transport", "Transforming growth factor beta activation", "Transforming growth factor beta production", "Transforming growth factor beta receptor signaling pathway", "Transforming growth factor beta1 production", "Transition between fast and slow fiber", "Transition metal ion homeostasis", "Transition metal ion transport", "Translational elongation", "Translational initiation", "Translational readthrough", "Translational termination", "Translesion synthesis", "Translocation of molecules into host", "Transmembrane receptor protein serine threonine kinase signaling pathway", "Transmembrane receptor protein tyrosine kinase signaling pathway", "Transmembrane transport", "Transmission of nerve impulse", "Transport along microtubule", "Transport of virus", "Transposition", "Transposition rna mediated", "Tricarboxylic acid cycle", "Tricarboxylic acid metabolic process", "Triglyceride biosynthetic process", "Triglyceride metabolic process", "Tripartite regional subdivision", "Tripeptide transmembrane transport", "Tripeptide transport", "Trivalent inorganic anion homeostasis", "Trna 3 end processing", "Trna 5 end processing", "Trna 5 leader removal", "Trna aminoacylation for mitochondrial protein translation", "Trna catabolic process", "Trna metabolic process", "Trna methylation", "Trna modification", "Trna processing", "Trna pseudouridine synthesis", "Trna thio modification", "Trna threonylcarbamoyladenosine metabolic process", "Trna transcription", "Trna transport", "Trna wobble base modification", "Trna wobble uridine modification", "Trophectodermal cell differentiation", "Trophoblast cell migration", "Trophoblast giant cell differentiation", "Tryptophan transport", "Tube development", "Tube formation", "Tube morphogenesis", "Tubulin complex assembly", "Tubulin deacetylation", "Tumor necrosis factor mediated signaling pathway", "Tumor necrosis factor superfamily cytokine production", "Type 2 immune response", "Type b pancreatic cell apoptotic process", "Type b pancreatic cell development", "Type i interferon production", "Type i pneumocyte differentiation", "Tyrosine catabolic process", "Tyrosine metabolic process", "Tyrosine phosphorylation of stat protein", "U4 snrna 3 end processing", "Ubiquinone metabolic process", "Ubiquitin dependent endocytosis", "Ubiquitin dependent erad pathway", "Ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin dependent smad protein catabolic process", "Ubiquitin independent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin recycling", "Udp glucose metabolic process", "Udp n acetylglucosamine biosynthetic process", "Udp n acetylglucosamine metabolic process", "Ump biosynthetic process", "Unsaturated fatty acid biosynthetic process", "Unsaturated fatty acid metabolic process", "Urate metabolic process", "Urate transport", "Urea cycle", "Urea metabolic process", "Ureter development", "Urinary bladder smooth muscle contraction", "Urinary tract smooth muscle contraction", "Urogenital system development", "Uronic acid metabolic process", "Uterus development", "Uterus morphogenesis", "Utp biosynthetic process", "Utp metabolic process", "Uv damage excision repair", "Uv protection", "V d j recombination", "Vacuolar acidification", "Vacuolar localization", "Vacuolar transport", "Vacuole organization", "Valine metabolic process", "Vascular associated smooth muscle cell apoptotic process", "Vascular associated smooth muscle cell differentiation", "Vascular associated smooth muscle cell migration", "Vascular associated smooth muscle cell proliferation", "Vascular associated smooth muscle contraction", "Vascular endothelial cell proliferation", "Vascular endothelial growth factor production", "Vascular endothelial growth factor receptor 2 signaling pathway", "Vascular endothelial growth factor receptor signaling pathway", "Vascular endothelial growth factor signaling pathway", "Vascular process in circulatory system", "Vascular transport", "Vascular wound healing", "Vasculature development", "Vasculogenesis", "Vasoconstriction", "Vasodilation", "Ventral spinal cord development", "Ventricular cardiac muscle cell action potential", "Ventricular cardiac muscle cell development", "Ventricular cardiac muscle cell differentiation", "Ventricular cardiac muscle cell membrane repolarization", "Ventricular cardiac muscle tissue development", "Ventricular cardiac muscle tissue morphogenesis", "Ventricular compact myocardium morphogenesis", "Ventricular septum development", "Ventricular septum morphogenesis", "Ventricular system development", "Very long chain fatty acid catabolic process", "Very long chain fatty acid metabolic process", "Very low density lipoprotein particle assembly", "Very low density lipoprotein particle clearance", "Vesicle budding from membrane", "Vesicle cargo loading", "Vesicle cytoskeletal trafficking", "Vesicle docking", "Vesicle docking involved in exocytosis", "Vesicle fusion to plasma membrane", "Vesicle fusion with golgi apparatus", "Vesicle localization", "Vesicle mediated transport", "Vesicle mediated transport between endosomal compartments", "Vesicle mediated transport in synapse", "Vesicle mediated transport to the plasma membrane", "Vesicle organization", "Vesicle targeting", "Vesicle targeting rough er to cis golgi", "Vesicle targeting to from or within golgi", "Vesicle tethering", "Vesicle tethering to golgi", "Vesicle transport along microtubule", "Vesicle uncoating", "Viral budding", "Viral gene expression", "Viral genome replication", "Viral life cycle", "Viral process", "Viral protein processing", "Viral release from host cell", "Viral rna genome replication", "Viral transcription", "Viral translation", "Viral translational termination reinitiation", "Virion assembly", "Virion attachment to host cell", "Visual behavior", "Vitamin a metabolic process", "Vitamin b6 metabolic process", "Vitamin biosynthetic process", "Vitamin catabolic process", "Vitamin d metabolic process", "Vitamin d receptor signaling pathway", "Vitamin k metabolic process", "Vitamin metabolic process", "Vitamin transmembrane transport", "Vitamin transport", "Vocalization behavior", "Voluntary musculoskeletal movement", "Walking behavior", "Water homeostasis", "Water soluble vitamin biosynthetic process", "Water soluble vitamin metabolic process", "White fat cell differentiation", "Wnt protein secretion", "Wnt signaling pathway involved in heart development", "Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "Wound healing", "Wound healing involved in inflammatory response", "Wound healing spreading of epidermal cells", "Xenobiotic catabolic process", "Xenobiotic export", "Xenobiotic metabolic process", "Xenobiotic transmembrane transport", "Xenobiotic transport", "Xenobiotic transport across blood brain barrier", "Xmp metabolic process", "Zinc ion homeostasis", "Zygotic determination of anterior posterior axis embryo", "Zymogen activation", "Zymogen inhibition"], "available_proteins": ["AAAS", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ACTR6", "ADAM17", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC5", "ANAPC7", "ANK3", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APOL2", "APOO", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG4B", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "B4GAT1", "BABAM1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCL2L12", "BCLAF1", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPTF", "BRCA1", "BRD2", "BRIX1", "BRMS1L", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BYSL", "BZW1", "C12orf43", "C12orf73", "C19orf70", "C1QBP", "CACYBP", "CAD", "CALD1", "CALR", "CAMK2D", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC47", "CCDC6", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD3EAP", "CDC123", "CDC23", "CDC27", "CDC34", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKAL1", "CEBPZ", "CECR2", "CELF1", "CENPI", "CERS2", "CFAP20", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD4", "CHERP", "CHID1", "CHKA", "CHMP3", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIAPIN1", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT10", "CNOT3", "CNOT6", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COG7", "COIL", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "CORO1B", "CORO1C", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DGCR8", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPF2", "DPH2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "ENSA", "ENY2", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERH", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAM120B", "FAM162A", "FAM208A", "FAM49B", "FAM8A1", "FAM98A", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FOXK1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GIGYF2", "GINS1", "GINS4", "GLA", "GLB1", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLGB1", "GORASP2", "GOT1", "GOT2", "GPAA1", "GPATCH4", "GPD2", "GPI", "GPR107", "GPR108", "GPS1", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAUS5", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIC2", "HIF1AN", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HOXA10", "HP1BP3", "HPF1", "HPRT1", "HPS6", "HSD17B10", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMPDH2", "INA", "INCENP", "INF2", "INTS11", "INTS14", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRS4", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC2", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMP1", "LAMTOR1", "LAMTOR2", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDAH", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3BP", "LGMN", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L3", "LYAR", "LYPLA1", "MACF1", "MAGED2", "MAGT1", "MAK16", "MAP1B", "MAP1S", "MAP2K1", "MAP4", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARCKSL1", "MARK2", "MARS", "MAT2A", "MATR3", "MAU2", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED16", "METAP2", "METTL13", "MFN1", "MFN2", "MGEA5", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MINPP1", "MKI67", "MLEC", "MMAB", "MMGT1", "MMS19", "MOGS", "MORF4L1", "MOV10", "MPHOSPH10", "MPI", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL44", "MRPL47", "MRPL58", "MRPL9", "MRPS11", "MRPS2", "MRPS27", "MRPS30", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MYBBP1A", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFAF7", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFCD", "NEMF", "NENF", "NES", "NEU1", "NHP2", "NIFK", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL11", "NOL6", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NPTN", "NRBP1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "OAT", "OCIAD1", "OCLN", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL11", "OSBPL6", "OSBPL9", "OTUB1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIGS", "PIGT", "PIN4", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLAA", "PLBD2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1R10", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PPP6R3", "PPT1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTRH2", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RABGGTA", "RAC1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAD51AP1", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "RECQL5", "REEP5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIF1", "RINT1", "RIOK2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF114", "RNF20", "RNF40", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF8", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC3A2", "SLC6A15", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX2", "SNX3", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPCS2", "SPCS3", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SQLE", "SQSTM1", "SRCAP", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSRP1", "SSU72", "STAG2", "STARD3", "STAT3", "STAU1", "STAU2", "STEAP3", "STIP1", "STMN1", "STOML2", "STRAP", "STRBP", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TACO1", "TAF15", "TAGLN2", "TALDO1", "TAMM41", "TAP1", "TAP2", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF25", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TFAM", "TFG", "TFRC", "THG1L", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIPRL", "TJP1", "TJP2", "TK1", "TKT", "TLN1", "TM9SF3", "TMCO1", "TMED10", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM126B", "TMEM201", "TMEM214", "TMEM230", "TMEM33", "TMEM43", "TMEM65", "TMEM97", "TMOD3", "TMTC3", "TMX1", "TMX2", "TNKS1BP1", "TNPO1", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TP53", "TP53BP1", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC5", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRMT6", "TRMU", "TRNT1", "TROVE2", "TSC2", "TSFM", "TSG101", "TSN", "TSPAN6", "TSR1", "TSTA3", "TTC1", "TTC19", "TTC21B", "TTC26", "TTC37", "TTC4", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBL5", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UCHL5", "UFC1", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF3B", "UQCR10", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USO1", "USP10", "USP14", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VPS13A", "VPS16", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WBP11", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR43", "WDR45B", "WDR46", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIZ", "WRAP53", "XAB2", "XPNPEP1", "XPO1", "XPO4", "XPO5", "XPO7", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YEATS2", "YEATS4", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBTB10", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZDHHC20", "ZFYVE16", "ZMPSTE24", "ZMYM4", "ZNF148", "ZNF281", "ZNF318", "ZNF326", "ZNF638", "ZRANB2", "ZW10", "ZYX"], "leading_proteins": ["AASDHPPT", "ABCB1", "ABCC4", "ABCD3", "ACAA2", "ACACB", "ACADM", "ACO1", "ACOT7", "ACP2", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR6", "ADH5", "ADNP", "AHCYL1", "AIFM1", "AIMP2", "AIP", "AK1", "AK6", "AKAP13", "AKR1B1", "AKT2", "ALDOA", "ALKBH5", "ANK3", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "AP1M1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEX1", "API5", "APLP2", "APOL2", "APP", "APRT", "ARCN1", "ARF4", "ARL1", "ARL6IP1", "ARMCX3", "ARPC1B", "ASAH1", "ASNS", "ASPH", "ATL2", "ATP13A1", "ATP1B1", "ATP1B3", "ATP2B1", "ATP2B4", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "B4GAT1", "BABAM2", "BAIAP2", "BASP1", "BAZ1B", "BAZ2A", "BCCIP", "BLM", "BLMH", "BRCA1", "BRD2", "BSG", "C12orf43", "C1QBP", "CAMLG", "CAPN2", "CAPRIN1", "CARM1", "CAST", "CBX3", "CCT2", "CCT3", "CCT4", "CCT7", "CCT8", "CD2AP", "CDC23", "CDC34", "CDC42", "CDK1", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CERS2", "CHERP", "CHKA", "CHMP3", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CIAPIN1", "CLASP1", "CLASP2", "CLCN3", "CLGN", "CLN5", "CLTC", "CLUH", "CMTR1", "CNNM4", "CNOT6", "COLGALT1", "COPB2", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS7A", "COPS8", "COTL1", "COX2", "COX7A2", "CPD", "CPSF6", "CPVL", "CSE1L", "CSNK1A1", "CSNK2B", "CSRP2", "CTNNA1", "CTNNB1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL5", "CUTA", "CYB5D2", "CYFIP1", "CYP51A1", "DAZAP1", "DCPS", "DCTN1", "DDX1", "DDX23", "DDX39A", "DDX3X", "DDX56", "DHCR24", "DHCR7", "DHX29", "DIEXF", "DIS3", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DPH2", "DSG2", "DTYMK", "DUT", "DYNLL1", "ECE1", "EEF1A2", "EFL1", "EHD1", "EIF2B3", "EIF2B5", "EIF2S2", "EIF3A", "EIF3D", "EIF3G", "EIF3L", "EIF4A3", "EIF4G1", "EIF4H", "EIF5", "EIF6", "ELAC2", "EMC4", "EMD", "ENY2", "EPHA7", "ERAP2", "ERGIC3", "EXD2", "EXO1", "EXOC7", "EXOSC3", "EXOSC7", "EZR", "F11R", "FAF1", "FAF2", "FAH", "FAM162A", "FAM49B", "FERMT2", "FKBP14", "FKBP7", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FRG1", "FTO", "FUCA2", "FUS", "FXR1", "G3BP1", "G3BP2", "GAA", "GALNT1", "GALNT2", "GARS", "GBA", "GCC2", "GCDH", "GDI2", "GGH", "GINS4", "GLA", "GLB1", "GLG1", "GM2A", "GNL1", "GNS", "GORASP2", "GPATCH4", "GPD2", "GPR107", "GPS1", "GRB2", "GRIPAP1", "GSK3A", "GSK3B", "GUSB", "HAUS5", "HAX1", "HDAC1", "HDAC2", "HDGFL2", "HELLS", "HEXA", "HEXB", "HLA-A", "HLA-B", "HLA-C", "HMGB1", "HMGB2", "HMGB3", "HMOX2", "HNRNPAB", "HNRNPD", "HPRT1", "HSP90AA1", "HSP90AB1", "HSPA13", "HSPA8", "HTRA2", "HUWE1", "HYOU1", "IFT27", "IGBP1", "IGF2BP1", "IGF2R", "IKBIP", "ILK", "IPO11", "IPO4", "IPO5", "IPO7", "IPO9", "IQGAP1", "IST1", "ITCH", "ITGB1", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KIF11", "KIF23", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KMT2A", "KPNA1", "KPNB1", "KYAT3", "LAMP1", "LAMTOR1", "LBR", "LEMD3", "LGALS3BP", "LGMN", "LIMA1", "LIPA", "LLGL1", "LMAN2", "LNPEP", "LRPAP1", "MAGED2", "MAP1S", "MAPRE1", "MAPRE2", "MARC1", "MBOAT7", "MCM2", "MCM7", "MCTS1", "MECP2", "MFN1", "MGST3", "MMGT1", "MMS19", "MPV17L2", "MRI1", "MTAP", "MTCH2", "MTOR", "MTPN", "MYH10", "MYH9", "NAA40", "NAGLU", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NASP", "NCAPD2", "NCAPG", "NCSTN", "NDRG3", "NDUFAF4", "NECAP1", "NECAP2", "NECTIN2", "NEDD4L", "NENF", "NEU1", "NIPBL", "NKTR", "NME1", "NNT", "NOL8", "NPC1", "NPC2", "NPEPPS", "NRBP1", "NRDC", "NSFL1C", "NSUN2", "NSUN5", "NTMT1", "NUCB1", "NUCB2", "NUCKS1", "NUDT9", "NUP188", "NUP35", "NUP37", "OCLN", "OSBP", "P3H1", "P3H4", "P4HA1", "P4HA2", "PACSIN2", "PAFAH1B1", "PAK2", "PAK4", "PARP1", "PBK", "PCM1", "PCYOX1", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDHX", "PDK3", "PDLIM5", "PFAS", "PFDN2", "PFDN5", "PFKL", "PGAM5", "PGRMC1", "PISD", "PITHD1", "PKN2", "PLAA", "PLBD2", "PLD3", "PLEC", "PLK1", "PLOD3", "PLS1", "POLR1C", "POLR3A", "POP1", "PPIB", "PPIL4", "PPP2R5D", "PPT1", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX4", "PREPL", "PRKACA", "PRKAR1A", "PRKAR2A", "PRMT1", "PRPSAP2", "PSMA6", "PSMB2", "PSMB6", "PSMC6", "PSMD10", "PSME4", "PSMG1", "PTBP1", "PTGES3", "PUF60", "PURA", "PWP1", "PYGL", "QKI", "QRSL1", "RAB24", "RAB3GAP1", "RAB5A", "RAB5B", "RAB7A", "RABGGTA", "RAD51AP1", "RALA", "RAN", "RANBP1", "RANBP2", "RBM8A", "RER1", "REXO2", "RHOG", "RINT1", "RIOK2", "RIPK1", "RNASET2", "RNF114", "ROCK2", "RPL10", "RPL24", "RPS17", "RPS3", "RTN4", "RUVBL2", "S100A10", "SAMHD1", "SAR1A", "SARNP", "SARS2", "SART3", "SCAF8", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCPEP1", "SDF4", "SEC31A", "SEPT7", "SET", "SF3A2", "SIRT2", "SLC12A2", "SLC1A5", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A20", "SLC25A32", "SLC25A33", "SLC35B2", "SLC35F2", "SLC3A2", "SLC6A15", "SLIT2", "SLK", "SMARCA5", "SMARCAD1", "SMC2", "SMC4", "SMYD3", "SNAP29", "SNRNP70", "SNW1", "SNX3", "SORT1", "SPART", "SPTLC1", "SQSTM1", "SRCAP", "SRI", 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2.6825757199168203 0.007305761099813 41.28398058252427 131.19174757281553 1.6327747521284677 0.3511039607499193 15.277988344159814 17.44963987873233 1.926180921267262 0.4033858283713009 0.0561151176528592 0.0086685285247613 0.0002888122165796 0.0001028849553625 +Intrinsic component of plasma membrane 20 56 2.6064890995637517 0.0091475735504515 29.711165048543688 79.49271844660194 0.9914207279546418 0.2992612012372248 13.467745416506318 12.62980929789956 2.1277799030157807 0.3627370007757806 0.007321286599909 0.0006136661339316 0.0051105964843199 0.3455873915123614 +Exocytic vesicle 9 28 2.586710104736699 0.0096897075946873 12.106796116504857 38.40533980582524 0.7408080162244459 0.4227017753873355 4.952517495270036 4.6543925000719675 1.3317240485888555 0.365166844745196 0.0288500723595301 0.0107481863467005 0.0182716334744495 0.0339287529861421 +Transport vesicle 13 70 2.563286208023814 0.010368653611076 26.046116504854368 92.34708737864078 0.9512017428916244 0.4458616213657612 9.46815354334768 9.09007867686459 1.424803887648301 0.3967491654773343 0.0016412724895022 0.0010260589016968 0.0048244272285524 0.0009741380253177 +Recycling endosome 11 32 2.5354990583422183 0.0112287230354284 11.66504854368932 38.48300970873787 0.3314123370484901 0.5655153978404952 4.733627044629046 5.712973030267684 1.060328776827888 0.3489425897551162 0.0339635306200824 0.0138909154909832 0.0091074173292525 0.0018765123351574 +External side of plasma membrane 7 19 2.5312900619800742 0.0113643825466385 6.856796116504855 22.03640776699029 0.7617836494895279 0.3205100812766187 3.0547396608098576 3.343757364022431 1.3549821177336052 0.303342613906597 0.0150293110048508 0.0202123812402064 0.014982846631896 0.0741297288399423 +Secretory granule membrane 16 55 2.5025028548291304 0.0123318630935671 19.699029126213592 69.8495145631068 0.9295860214656708 0.3887665887416008 7.284889203542463 7.49087955205396 1.5950364553562375 0.3903287060113383 0.0117205067001905 0.0086691972080798 0.0001373530530939 6.95974025668799e-05 +Side of membrane 20 54 2.499699496526462 0.0124298692398681 17.526699029126213 71.19660194174757 0.4235531336200628 0.5236659753791312 6.9409272887607125 8.635706418493163 1.198097658489356 0.36822581052137 0.0072215435093696 0.0111193401213695 0.0080962075428934 0.0051594379081403 +Perinuclear region of cytoplasm 23 146 2.473808702816491 0.013368125566938 41.351941747572816 185.873786407767 0.188099869779145 0.7574745839917925 13.945452720131469 19.27429981182019 0.8259268596181808 0.3356085544002479 2.3995360235199763e-05 0.0036013169667894 0.0012504762626143 0.0046225994595964 +Blood microparticle 2 15 2.464792423058277 0.0137092646842185 4.735436893203883 17.08252427184466 0.278306270999014 0.48728609275096 2.8336409309630577 1.4740425350178823 1.0421411126986748 0.31816279579515 0.0179094063189584 0.00796664232011 0.0824073873197279 0.1473962800256471 +Intrinsic component of organelle membrane 29 100 2.454895756351958 0.0140925447905035 52.51699029126213 129.34223300970874 2.0732064315361294 0.2796588394070637 24.692225942786415 15.820346456508432 2.8130846896968285 0.39829365000917 0.0155278135290064 0.000716051803987 4.283158910829749e-06 1.066130889379232e-05 +Early endosome membrane 8 32 2.341678889074 0.0191972236535622 12.29611650485437 44.95873786407767 0.5277524243262064 0.5849546522697281 4.982462882428341 7.094079738701261 0.90392558948614 0.3412735259006035 0.1234363306283571 0.033448252195247 0.0109429993819088 0.0074349637262686 +Vesicle membrane 48 181 2.3169429902944856 0.0205068375059571 59.03398058252427 252.66747572815535 0.5350285241159404 0.6113983912197217 17.512237349079548 29.567983380691818 1.3292572988488431 0.402876017449685 1.2404547857476872e-05 0.0001463156354397 1.460852518251635e-06 3.7849829853085146e-06 +Clathrin coated vesicle 8 39 2.277715053742326 0.0227435602410974 9.936893203883496 47.157766990291265 0.2628715125167937 0.534532305855711 4.553447222704333 4.879804116719352 1.1779559306555245 0.358217133589648 0.0003112252912225 0.0068883475156431 0.0029656012408738 0.0064995796940839 +Coated vesicle 13 69 2.274301026865209 0.0229478934735676 21.15776699029126 89.28398058252426 0.7996411773181966 0.4463095457932411 7.252509633536616 8.542551157088123 1.3406722753228342 0.3892656029628454 0.0004202884338454 0.0035546516204206 0.0004073462223441 4.402155077601716e-05 +Neuromuscular junction 4 15 2.201313553085724 0.0277138340613156 4.62621359223301 16.633495145631066 0.4855035135155566 0.54061233402628 2.386469186408936 2.9236472131013795 0.8090611388618595 0.3124321260069755 0.1908924307699622 0.0663348012473392 0.0037658297098364 0.0172802721197194 +Clathrin coated endocytic vesicle membrane 2 11 2.1994593591512865 0.0278452758738505 3.796116504854369 13.682038834951456 0.0573666642471241 0.400612365903674 2.3816010903207343 1.646817383208435 1.3652035545006669 0.3297171871883064 0.0006503204391585 0.0047719907059414 0.0100334254948701 0.0893349628841762 +Golgi associated vesicle 2 21 2.1884570323134453 0.0286363278375232 6.745145631067961 30.33009708737864 0.696501539533066 0.3869218626415568 3.3093865809086713 3.3403631844705557 1.2881306559419168 0.3350067162782171 0.0044455523824174 0.0289872856979344 0.230981979145724 0.0055572149230821 +Membrane microdomain 7 51 2.1862930005988206 0.0287941759014946 14.75485436893204 63.49029126213592 0.5762129399877682 0.5023556315347317 6.545256989336744 6.436953608643344 1.167657055169838 0.3823949317010994 0.0025062796340618 0.0418342338514673 0.1028045982795446 0.0280092641420705 +Phagocytic vesicle 9 34 2.1848925582902976 0.0288967252834335 11.54126213592233 41.59708737864078 0.3919256884663005 0.5681630099638236 4.854259100699266 4.0100348958770144 0.9938295058309184 0.3509625084864278 0.086158736226278 0.0166753185858976 0.0001584508875138 0.0003377595891643 +Ficolin 1 rich granule 8 77 2.1829607754174303 0.0290386987257542 23.65776699029126 87.40776699029126 -0.2227524879803391 0.5328920793977936 13.237445521916472 3.951617324550425 1.218029306074882 0.3604375114796861 0.004569571219218 0.0023202162213214 0.0005528694786536 0.0001275121111297 +Tertiary granule 5 34 2.1621875176146084 0.0306037252918787 10.41504854368932 41.036407766990294 -0.0889487004392956 0.5196752089107607 4.251221040765739 3.0949590565759384 1.1107953602779526 0.3305399634314611 0.0746572323120207 0.0126050270587289 0.0248959026754067 0.1623206972812187 +Presynapse 17 74 2.117739486664966 0.0341971367438003 22.813106796116504 90.997572815534 0.4365135448276876 0.6534842370695999 7.919284748658944 8.50627945845188 0.826940228235506 0.3445781590237917 0.1610739044788785 0.0593972116085724 0.0867724217460314 0.0209775069478481 +Azurophil granule membrane 5 17 2.0771409050621936 0.0377885561678361 7.856796116504855 21.259708737864077 1.0757479237162697 0.2373572682944545 3.393508570011604 2.63895903142419 1.639408148995933 0.2881313440808664 0.0212633176973237 0.0102417527095019 0.0008248401262711 0.0015476035169576 +Clathrin coated pit 3 18 2.042915472512586 0.0410608063899093 6.813106796116505 23.92233009708738 -0.3634603746412232 0.5290548253531329 3.4198908541960824 3.6938398480544263 1.0001526474813611 0.326415656204558 0.0026953565990113 0.0182749379957494 0.0501037692041591 0.1445053403031155 +Phagocytic vesicle membrane 7 18 2.0358224774668963 0.0417681844943702 7.512135922330097 23.83009708737864 0.5348434256443761 0.4468744105904624 3.681144332021715 3.0024693704800938 1.1652764437248655 0.3385441964418395 0.0358926009784828 0.0218582842409203 0.0001087627785303 0.0006724730831873 +Late endosome 14 46 2.032912171262153 0.0420613971489838 15.655339805825244 65.18203883495146 0.1482522199608934 0.3683478922291265 6.675389202214119 9.543379127098556 1.7080817701484334 0.368772234437858 0.0004667626748371 3.108682863790864e-05 4.114657018261854e-05 0.0114863194297596 +Multivesicular body 3 9 2.01375705148556 0.0440350469162307 3.7742718446601944 12.094660194174756 0.0270444117783637 0.5442226252774409 2.4800207883335372 2.61498122866677 0.9464580912617488 0.3033802150556732 0.1828652209005429 0.3329579057594876 0.0173259681631819 0.1383493461091194 +Clathrin coated endocytic vesicle 2 14 2.005695493008752 0.0448887463732992 4.774271844660194 18.74271844660194 -0.0983362729934113 0.4816370533307881 3.136849294900222 2.1033538609603957 1.2416005860349415 0.3436375292109884 0.0013622028220488 0.0096414106757913 0.0236436874746125 0.1758221500942633 +Apical part of cell 12 45 1.9876403130844504 0.0468514844505267 15.599514563106796 57.72330097087379 0.5629683512109013 0.5412025823450395 6.485031290002554 7.326381428218615 1.086566128273008 0.3654459232984969 0.2534003994396064 0.3073420480660703 0.354485634221641 0.0329831328597672 diff --git a/msigdb_gocc/metrics.json b/msigdb_gocc/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..2952722d293cb52a0741c3e610252b3b551c6e55 --- /dev/null +++ b/msigdb_gocc/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2453, + "annotations_size": 882, + "title": "Average number of proteins per term", + "value": 23.467120181405896 +} \ No newline at end of file diff --git a/msigdb_gocc/paths.json b/msigdb_gocc/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..6a4dc07b958d57f0f16ceed29b165816ba676b27 --- /dev/null +++ b/msigdb_gocc/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gocc/fragment/C334/C334_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gocc/result.tsv b/msigdb_gocc/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..476306368673997276ad7614e117f4755b54c1bd --- /dev/null +++ b/msigdb_gocc/result.tsv @@ -0,0 +1,283 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Vacuole 0.679195873077532 4.506074859711867 6.603779808989074e-06 0.0058076232001204 0.0035421185179047 163 O00584,Q8NHP8,Q9UIQ6,O75503,P06280,P11117,Q8IV08,Q99538,P61916,Q9BTY2,P10253,P17900,P42892,P50897,Q14108,P16278,P15586,P06865,Q99519,P11279,Q8WTV0,P07686,P10619,Q99523,O14773,O15118,Q92820,P54802,P51790,Q92542,P38571,Q5BJF2,Q13510,Q13501,Q14849,P04062,P08236,O75436,P08195 39 +Vacuolar lumen 0.8840943451855102 4.463155375437715 8.076144552005005e-06 0.0070978784844563 0.0035421185179047 54 O00584,Q8NHP8,P06280,P11117,Q8IV08,Q99538,P61916,Q9BTY2,P10253,P17900,P50897,Q14108,P16278,P15586,P06865,Q99519,P07686,P10619,O14773,Q92820,P54802,P38571,Q13510,P04062 24 +Vesicle lumen 0.6638460045227229 4.0907121943136735 4.300505375631758e-05 0.0372208924985751 0.0035421185179047 102 P05067,Q99519,O00584,Q08380,P06280,P07686,P10619,P61916,Q9BTY2,P17900,Q92820,P08236,P16278,P15586 14 +Lysosomal lumen 0.9532022285438234 3.9402792513487506 8.138681322211738e-05 0.0692700335199142 0.0035891584630954 30 O00584,Q8NHP8,P06280,P11117,Q8IV08,Q99538,P61916,P10253,P17900,P50897,Q14108,P16278,P15586,P06865,Q99519,P07686,P10619,O14773,P54802,P38571,Q13510,P04062 22 +Azurophil granule 0.7687696746571541 3.757778167369884 0.0001714287509178 0.1403355324000434 0.0053856682475458 55 P06865,O00584,P11279,P06280,P07686,P10619,P61916,Q9BTY2,P10253,P17900,Q92820,Q92542,P08236,P16278,P15586 15 +Endoplasmic reticulum 0.4431741089175189 3.741862659829114 0.0001826613384643 0.1488117941117857 0.0053856682475458 375 Q6UXD5,P05067,Q10472,O00584,O75503,Q8IXB1,Q8IV08,P61916,Q9BTY2,Q8IY95,Q9UMX5,Q9Y282,Q5J8M3,Q14108,Q06481,Q15904,Q96G23,P10619,Q99523,O15118,Q10471,Q92542,Q5BJF2,O43852,Q13510,Q13501,P30519,Q02818,Q9HD20,Q9UBM7,P10321,Q9UQB8,P48723,P80303,Q14849,Q9BRK5,P51809,P01889,Q15392,P04062,O95881,Q03519,Q14257,O15269,Q15334,Q14739,Q5W0Z9,O95456,Q9BQE5,Q9NWM8,Q01105,Q8N4V1,O43464,P35613 54 +Early endosome 0.6595182958292897 3.415501770603326 0.0006366461556202 0.4297615832126898 0.0110102335148435 71 P05067,Q96AX1,Q5VW38,O75436,Q86Y82,Q9UIQ6,P10321,Q8IV08,Q99523,P02786,P01889,Q8N4V1,P51790,Q92542,P11717,Q06481,Q13510 17 +Azurophil granule lumen 0.8074517317419354 3.3956207823858136 0.0006847315536957 0.4534557970182934 0.0116141005838394 35 O00584,P06280,P07686,P10619,P61916,Q9BTY2,P17900,Q92820,P16278,P15586 10 +Cell surface 0.684106286979424 3.3697290443044183 0.0007524213009719 0.485152932917594 0.0125214261784392 62 P05067,Q92692,P02786,P42892,P11717,P11279,Q8WTV0,Q99523,P51790,P05556,Q9ULM6,P10321,Q14126,P01889,O43847,Q12907,Q07021,P11233,P08195 19 +Secretory granule 0.5679983457310444 3.3528146091884268 0.0007999426917941 0.5063022564980508 0.0130657306326382 190 P05067,O00584,Q08380,P06280,P61916,Q9BTY2,P10253,P17900,P42892,P11717,Q06481,P16278,P15586,P06865,Q99519,P11279,P07686,P10619,Q92820,P51790,Q92542,Q13510,P10321,Q9UQB8,P08236,P67870,P42785 27 +Endosome 0.5649924423394432 3.3227865847952005 0.0008912307109303 0.5445256967043651 0.0137906225796588 151 P05067,Q5VW38,Q9UIQ6,O15127,Q8IV08,Q99538,P02786,Q8IY95,P42892,Q93050,P11717,Q14108,P13693,Q06481,Q658P3,P11279,Q15904,Q99523,O00461,O14773,O15118,Q9Y487,P51790,Q92542,P05556,Q13510,Q13501,Q96AX1,Q86Y82,P10321,P51809,Q14849,Q9BRK5,O75436,Q8N4V1,P35613 36 +Secretory vesicle 0.557297701020765 3.266627807596573 0.0010883666729784 0.6172840339526955 0.0157367115666713 207 P05067,O00584,Q08380,P06280,P61916,Q9BTY2,P10253,P17900,P42892,P50897,O43760,Q93050,P11717,Q06481,P16278,P15586,P06865,Q99519,P11279,P07686,P10619,Q9Y487,Q92820,P51790,Q92542,Q13510,P30519,Q86Y82,P10321,Q9UQB8,P51809,P01889,P08236,Q15334,O95721,P67870,P42785,P84095,P17858,P35613 40 +Vacuolar membrane 0.6000527834141998 3.243669563697427 0.0011800055182185 0.6470325389753576 0.0167865301140116 92 Q9UIQ6,O75503,P11117,Q8IV08,P10253,Q8IY95,P42892,Q93050,Q14108,Q99519,P11279,Q8WTV0,P10619,Q99523,Q9Y487,O15118,P51790,Q92542,Q99747,Q96AX1,P51809,Q14849,P04062,Q9BZH6,O95721,P08195,P42785 27 +Endocytic vesicle 0.6238526266955654 3.0699998071844927 0.0021405890913039 0.8489316933452415 0.0258630079250701 67 P11279,Q8WTV0,Q86Y82,P10321,P11233,Q9Y487,P02786,O00461,P51809,P01889,P51790,Q03519,Q93050,P11717,Q14108,Q06481 16 +Golgi apparatus 0.5194038324404366 2.8420099943166823 0.0044830086192959 0.9809921479339032 0.0494251700277379 219 P05067,Q10472,Q5VW38,O75503,P06280,O15127,Q8IV08,Q8IY95,P50897,Q9Y282,O43505,Q93050,P11717,Q14108,P16278,Q99523,O00461,O14773,O15118,Q10471,P51790,Q92542,Q92896,Q6ZRP7,O43852,Q02818,Q86Y82,P10321,Q9UQB8,P80303,P51809,P01889,Q9BRK5,Q15392,P04062,Q15334,Q12907,Q5W0Z9,O95456,Q9BZH6,Q8N4V1,P35613,Q8NCH0 43 +Endocytic vesicle membrane 0.7368207542997155 2.8271572419961584 0.0046963261123191 0.9842657695630656 0.0506117252242253 31 P11279,Q8WTV0,P10321,Q9Y487,P02786,P51809,P01889,Q03519,Q93050,P11717,Q14108,Q06481 12 +Endosome membrane 0.555136739510217 2.8265391971181306 0.0047053984902341 0.9843917598260457 0.0506117252242253 92 O15127,Q8IV08,P02786,P42892,Q93050,P11717,Q14108,Q06481,Q658P3,P11279,Q15904,Q99523,O00461,Q9Y487,O15118,P51790,Q92542,P05556,Q96AX1,Q86Y82,P10321,P51809,Q14849,P01889,Q15334,O75436,Q8N4V1 27 +Pigment granule 0.6233648607234087 2.781300902132471 0.0054141528882309 0.9916730393121928 0.0568486053264254 57 P55209,P11279,P08195,O14773,P02786,Q92820,Q92542,Q93050,P35613,O43852 10 +Endoplasmic reticulum lumen 0.6319418290351937 2.699633690594047 0.0069415859554695 0.9978533086357017 0.0687918967721815 50 P05067,Q02818,O00584,Q8IXB1,Q9Y680,Q9NWM8,Q9BTY2,O95881,Q14257,Q06481,O43852 11 +Golgi membrane 0.5400665009613628 2.6825757199168203 0.007305761099813 0.99844663939366 0.0704327578693885 92 Q10472,Q9H3P7,Q8IV08,P40616,Q9Y282,O43505,Q9BVK6,P11717,Q14108,Q8TB61,O15258,P04439,O00461,Q10471,P24390,P51790,Q6ZRP7,Q92896,Q86Y82,P10321,P01889,Q9UM00,Q15392,Q15334,Q12907,Q5W0Z9,Q9BW83,O95721,Q9Y678,P42345,Q8N4V1,P35606,Q7Z6Z7,P35613,Q8NCH0,Q9H8Y8 36 +Autolysosome 0.9742962056303556 2.61690222796692 0.008873175315931 0.999614538313604 0.0774865408777342 2 P11279 1 +Secondary lysosome 0.9742962056303556 2.61690222796692 0.008873175315931 0.999614538313604 0.0774865408777342 2 P11279 1 +Intrinsic component of plasma membrane 0.603252301806699 2.6064890995637513 0.0091475735504515 0.9996980618951792 0.0790996065833167 56 P05067,Q9UIQ6,P02786,P11717,P11279,Q8WTV0,O15118,Q15375,P51790,Q92542,Q9H2J7,O43657,P05556,P55011,Q9ULM6,P10321,P01889,Q15334,O43464,P35613 20 +Exocytic vesicle 0.7104261728547172 2.586710104736699 0.0096897075946873 0.9998136711083768 0.0826826240441735 28 P05067,P11279,Q86Y82,O43760,P50897,P51790,Q92542,Q9BVK6,Q15334 9 +Transport vesicle 0.5569645286262664 2.563286208023814 0.010368653611076 0.9998982400798138 0.0862750234431048 70 P05067,P11279,Q86Y82,P10321,Q99523,O00461,P51809,P01889,O43760,P50897,P51790,Q92542,P11717 13 +Recycling endosome 0.6814567090641268 2.5354990583422183 0.0112287230354284 0.9999527357626904 0.0914038083042851 32 P05067,Q86Y82,O14828,Q9H4M9,O15127,P10321,P02786,O14773,P01889,P51790,P05556 11 +External side of plasma membrane 0.7725558425748114 2.5312900619800742 0.0113643825466385 0.9999581230672996 0.0914038083042851 19 P11279,Q9ULM6,P02786,P42892,P08183,P51790,P05556 7 +Secretory granule membrane 0.5923722812428902 2.5025028548291304 0.0123318630935671 0.9999823420555284 0.0961679356979269 55 P11279,P10321,O95721,P51809,P01889,Q969Q5,P42785,P10253,P84095,O15439,Q92542,Q93050,P11717,P35613,Q06481,P30519 16 +Side of membrane 0.594640585959605 2.499699496526462 0.0124298692398681 0.9999838218634234 0.0961679356979269 54 P24666,P02786,P17900,P42892,O15439,Q96AC1,Q05639,P11279,O75955,P10619,P51790,P05556,Q9ULM6,Q96A49,P10321,P01889,P20020,Q15334,P08183,O43464 20 +Perinuclear region of cytoplasm 0.4886916280854068 2.473808702816491 0.013368125566938 0.9999930042372748 0.1025277108699071 146 P05067,Q10472,Q9UIQ6,O75503,Q99538,P02786,Q8IY95,P42892,Q93050,P11717,P16278,P11279,Q99523,Q9Y487,O15118,Q10471,Q66K74,P05556,Q96AX1,Q5W0Z9,Q15056,Q01105,O95831 23 +Blood microparticle 0.8155960736771634 2.464792423058277 0.0137092646842185 0.999994843332992 0.104237684926558 15 Q08380,P02786 2 +Intrinsic component of organelle membrane 0.500468980161842 2.454895756351958 0.0140925447905035 0.9999963399679794 0.1062361068822578 100 P42892,Q9Y282,O43505,O60830,Q5J8M3,Q8TB61,O15118,Q10471,Q8IWA4,O96008,Q6ZRP7,Q9UBM7,Q86Y82,Q99595,P10321,O75844,P49069,P01889,Q9Y2U8,O14925,Q9UM00,Q03519,Q5SNT2,Q14739,Q5W0Z9,Q9UG56,Q8N4V1,O43808,Q9UH62 29 +Early endosome membrane 0.6496333692318212 2.341678889074 0.0191972236535622 0.9999999624121472 0.1343805655749357 32 Q86Y82,P10321,Q8IV08,P01889,Q8N4V1,P51790,Q15334,Q06481 8 +Vesicle membrane 0.4813938177147384 2.3169429902944856 0.0205068375059571 0.9999999884324214 0.1402095401570094 181 Q9UIQ6,Q9H4M9,O15127,Q8IV08,P02786,O43760,P10253,P42892,Q8NC96,O15439,Q93050,P11717,Q14108,Q06481,Q658P3,P61421,P11279,Q8WTV0,Q15904,O14828,Q9NVZ3,Q99523,O00461,Q9Y487,O15118,Q969Q5,P24390,P51790,Q92542,P05556,P30519,P55011,Q96AX1,Q86Y82,P10321,P51809,Q14849,P01889,Q03519,Q15334,O75436,P11233,O95721,Q9Y3E7,P42785,P84095,Q8N4V1,P35613 48 +Clathrin coated vesicle 0.5984619967718854 2.277715053742326 0.0227435602410974 0.999999998459956 0.1488452852911556 39 Q96AX1,Q5VW38,Q99523,P02786,P42892,Q8NC96,P11717,Q14108 8 +Coated vesicle 0.5243787285172884 2.274301026865209 0.0229478934735676 0.99999999871934 0.1488452852911556 69 P05067,Q96AX1,Q5VW38,P10321,Q99523,P51809,P02786,P01889,P42892,Q8NC96,Q9Y282,P11717,Q14108 13 +External side of apical plasma membrane 0.887392900856794 2.253573420038475 0.0242230170468569 0.9999999995952356 0.1515227023782113 2 P08183 1 +Bleb 0.8780089759281962 2.2135381536753 0.02686056582999 0.9999999999628112 0.1611633949799404 2 Q9BRK5 1 +Neuromuscular junction 0.757316950217556 2.2013135530857237 0.0277138340613156 0.9999999999828446 0.1637302221382412 15 O43760,P05067,Q15375,P05556 4 +Clathrin coated endocytic vesicle membrane 0.8114176829374091 2.1994593591512865 0.0278452758738505 0.999999999984773 0.1637302221382412 11 P11717,P02786 2 +Golgi associated vesicle 0.6823070495155727 2.1884570323134453 0.0286363278375232 0.9999999999925732 0.1650236896002223 21 P05067,P11717 2 +Membrane microdomain 0.5604547136248889 2.1862930005988206 0.0287941759014946 0.999999999993565 0.1650236896002223 51 P05067,Q8WTV0,O14773,O15118,P50897,P35613,P05556 7 +Phagocytic vesicle 0.6144426964192043 2.1848925582902976 0.0288967252834335 0.9999999999941372 0.1650236896002223 34 P11279,Q86Y82,P10321,Q9Y487,P51809,P01889,P51790,Q93050,Q06481 9 +Ficolin 1 rich granule 0.5084707626523143 2.1829607754174303 0.0290386987257542 0.9999999999948466 0.1650236896002223 77 P11279,P67870,P42785,P10253,P08236,P15586,P16278,Q13510 8 +Tertiary granule 0.6109278814794016 2.1621875176146084 0.0306037252918787 0.9999999999987578 0.1719266605569237 34 P11279,P42785,P10253,Q92820,Q13510 5 +Endosome lumen 0.9710589547312056 2.126446877271361 0.0334660680577756 0.9999999999999084 0.1833358510991187 4 P05067,Q9UIQ6 2 +Presynapse 0.503798364379051 2.117739486664966 0.0341971367438003 0.999999999999953 0.185042175509398 74 P05067,P61421,P11279,Q96A49,Q86Y82,Q06787,O95721,Q07021,Q9UQB8,Q96HC4,O43760,P50897,P51790,Q92542,P51114,Q9BVK6,Q15334 17 +Azurophil granule membrane 0.7053070028054754 2.0771409050621936 0.0377885561678361 0.9999999999999982 0.1995778834732424 17 P11279,P51809,P42785,P10253,Q92542 5 +Clathrin coated pit 0.6870158918181462 2.042915472512586 0.0410608063899093 1.0 0.2105808899735792 18 P05067,Q99523,P02786 3 +Phagocytic vesicle membrane 0.6856087919492669 2.0358224774668963 0.0417681844943702 1.0 0.2113837943511657 18 P11279,P10321,P51809,Q9Y487,P01889,Q93050,Q06481 7 +Late endosome 0.5492442234237233 2.032912171262153 0.0420613971489838 1.0 0.2113837943511657 46 Q13501,Q96AX1,P11279,Q8IV08,Q99538,P13693,Q14849,O15118,Q9BRK5,Q8IY95,P51790,P11717,Q14108,Q658P3 14 +Multivesicular body 0.7910405035073216 2.01375705148556 0.0440350469162307 1.0 0.2157717298895305 9 P11279,P13693,Q658P3 3 +Clathrin coated endocytic vesicle 0.7285020266718876 2.005695493008752 0.0448887463732992 1.0 0.2179380984106406 14 P11717,P02786 2 +Apical part of cell 0.5447029383059103 1.9876403130844504 0.0468514844505267 1.0 0.2233676177587276 45 P55011,P05067,P61421,P05026,P08195,Q99538,O00165,P54709,P08183,O15439,P51790,P20020 12 +Golgi lumen 0.9313275641253684 1.97963317712542 0.0477447621776472 1.0 0.224160632162506 4 P05067,O00461 2 +Intrinsic component of golgi membrane 0.8252930157052917 1.956026289227567 0.0504620572888192 1.0 0.2328587355601898 8 Q5W0Z9,Q10471,O43505,Q6ZRP7,Q9Y282 5 +Golgi cisterna membrane 0.7753252140881869 1.9491783118445831 0.0512741340638238 1.0 0.2328587355601898 9 Q10472,Q99523,O00461 3 +Epsilon dna polymerase complex 0.8164014687882524 1.9470228883188536 0.0515319906929216 1.0 0.2328587355601898 2 Q9NRG0 1 +Acrosomal membrane 0.8159934720522292 1.9452376226520336 0.0517463856800421 1.0 0.2328587355601898 2 P35613 1 +Nuclear envelope lumen 0.9142743064515731 1.9346643712443912 0.0530314951994759 1.0 0.2374303490656739 5 P05067 1 +Organelle envelope lumen 0.5771511805351137 1.911298278043534 0.0559662602335437 1.0 0.2468112076299281 33 P05067,P11717,O00584,O43464 4 +Golgi cisterna 0.7372282739518375 1.8846164537056416 0.0594816392575441 1.0 0.2559161259763606 11 Q10472,Q10471,Q99523,O00461 4 +Clathrin coated vesicle membrane 0.6440441797840544 1.8803506372379368 0.0600603063269771 1.0 0.2571514086426884 19 Q14108,P11717,Q8NC96,P02786 4 +Golgi apparatus subcompartment 0.5110445653084108 1.8779096219176303 0.0603935298817661 1.0 0.2573289534092645 56 P05067,Q10472,Q9BZH6,O14828,O15127,Q99523,O00461,P51809,Q10471,P04062,P11717,Q15334 12 +Trans golgi network transport vesicle 0.7429965117779287 1.8610478628852305 0.062737417903079 1.0 0.2660307816851718 10 P11717 1 +Proton transporting v type atpase complex 0.745847791030447 1.82682709518901 0.0677257706110441 1.0 0.2831001406584877 9 Q93050,Q15904,Q9Y487 3 +Recycling endosome membrane 0.6410282220994153 1.8081825354540095 0.0705780958403601 1.0 0.2935051716124432 18 Q86Y82,Q9H4M9,O15127,P10321,P01889,P02786 6 +Proton transporting v type atpase v0 domain 0.8824489795918362 1.8019959342830751 0.0715460452343257 1.0 0.2935051716124432 3 Q93050,Q9Y487 2 +Vacuolar proton transporting v type atpase v0 domain 0.8824489795918362 1.8019959342830751 0.0715460452343257 1.0 0.2935051716124432 3 Q93050,Q9Y487 2 +Specific granule lumen 0.7068496521179489 1.7993840731350486 0.0719579471984022 1.0 0.2938282843934757 12 Q99519 1 +Dendritic shaft 0.8753971851441836 1.79051120543958 0.073371767492004 1.0 0.2954972553787559 5 P05067 1 +Glial cell projection 0.8680904583028357 1.763221962951908 0.077863060920172 1.0 0.3046000182395418 5 P05067,P05556 2 +Torc1 complex 0.7739698082415372 1.7600767795380765 0.0783947892748027 1.0 0.3046000182395418 2 P42345 1 +Tor complex 0.7739698082415372 1.7600767795380765 0.0783947892748027 1.0 0.3046000182395418 2 P42345 1 +Ficolin 1 rich granule membrane 0.6496303543598673 1.7520468150868431 0.0797657583290618 1.0 0.3076209923205513 16 P42785,P10253,P11279 3 +Golgi stack 0.6391944925597024 1.7472535889542709 0.0805933597672761 1.0 0.3076209923205513 17 Q10472,Q10471,Q99523,O00461 4 +Neuron spine 0.5689977331973941 1.7448649431895176 0.0810083809297301 1.0 0.3076209923205513 28 P05067,Q06787,Q9UQB8,P51114,Q15334,P05556 6 +Lumenal side of membrane 0.726301622711258 1.7448508037878183 0.0810108427708555 1.0 0.3076209923205513 9 P10321,P10619 2 +Tim23 mitochondrial import inner membrane translocase complex 0.8620152640569996 1.72397489517759 0.084712375339174 1.0 0.3139340968451745 6 O60830,Q99595 2 +Cell body 0.456006313277015 1.7151694459317304 0.0863141649435854 1.0 0.3172045561676765 81 P55011,P05067,Q13547,Q9ULM6,Q00577,Q96A49,P51114,Q06787,P08195,Q9UQB8,Q14203,Q15375,P50897,Q66K74 14 +Trans golgi network membrane 0.6386687694883578 1.6975519846122584 0.0895923517096364 1.0 0.3225324661546911 16 P05067,O14828,O15127,P11717,Q15334 5 +Intraciliary transport particle b 0.7580579355365199 1.6893680663728845 0.0911489167076664 1.0 0.3268022135616334 2 Q9BW83 1 +Dendritic spine membrane 0.7552019583843375 1.6766463556083295 0.0936116563632827 1.0 0.3302619236496614 2 P20020 1 +Dendrite cytoplasm 0.6879960947373225 1.669618357564167 0.0949948959867521 1.0 0.3321557700390271 11 Q9NUL3,Q00577,Q9UQB8,Q15334 4 +Neuron projection terminus 0.6666828756653195 1.6662195669651434 0.0956696900911819 1.0 0.3321557700390271 13 Q15334,P61421,Q9UQB8,P51790 4 +Somatodendritic compartment 0.4056943492526891 1.663246108227143 0.096263181478398 1.0 0.3321557700390271 111 P55011,P05067,Q13547,Q9ULM6,Q00577,Q96A49,P51114,Q06787,P08195,Q9UQB8,Q14203,Q15375,P50897,Q66K74,Q15334,P20020,P05556 17 +Amphisome 0.844155128804714 1.6536882671602258 0.0981908677789737 1.0 0.3356136348729491 3 Q13501 1 +Main axon 0.7921862404979527 1.6405219326047524 0.1008966920148166 1.0 0.3356136348729491 7 P05067 1 +Endoplasmic reticulum tubular network membrane 0.7470420236638078 1.6402515877293156 0.1009528670672461 1.0 0.3356136348729491 2 Q8NHH9 1 +Cortical endoplasmic reticulum 0.7380660954712406 1.6001424218478006 0.1095669918983461 1.0 0.3565514732339725 2 P50402 1 +Tertiary granule lumen 0.6413471239409616 1.5978543082671035 0.1100754048907242 1.0 0.3565514732339725 14 Q92820 1 +Mhc class i protein complex 0.8285714285714267 1.592957716481764 0.1111696770287329 1.0 0.3565514732339725 3 P10321,P01889 2 +Mhc protein complex 0.8285714285714267 1.592957716481764 0.1111696770287329 1.0 0.3565514732339725 3 P10321,P01889 2 +Multivesicular body membrane 0.731538147694826 1.570927448188845 0.1161995020840787 1.0 0.364725839281699 2 Q9Y3E7 1 +Amphisome membrane 0.731538147694826 1.570927448188845 0.1161995020840787 1.0 0.364725839281699 2 Q9Y3E7 1 +Escrt iii complex 0.731538147694826 1.570927448188845 0.1161995020840787 1.0 0.364725839281699 2 Q9Y3E7 1 +Basal cortex 0.724194206446346 1.538020512189985 0.1240435994981687 1.0 0.3838822973943328 2 Q7Z460 1 +Dendritic tree 0.430910744867149 1.5172881315438935 0.1291939533945008 1.0 0.3942874286987879 87 P05067,Q14168,Q7Z460,P17655,Q99729,Q14444,P50897,P27695,Q00577,Q06787,Q14247,Q9Y5K6,Q9NUL3,Q15375,Q66K74,P05556,Q96A49,Q14254,Q9UQB8,P51114,P23634,P20020,Q15334,P52294,Q9H2P0,P42345,P17612,P25685 28 +Intrinsic component of nuclear inner membrane 0.8084585522555467 1.514148018477545 0.1299883021675563 1.0 0.3953437327992574 4 Q5SNT2,Q14739 2 +Specific granule 0.5352711587919573 1.495134143241542 0.1348794366815815 1.0 0.400551054387727 25 Q99519,Q92820 2 +Platelet alpha granule 0.6177861907167066 1.4849021149739796 0.1375697557095732 1.0 0.4071695454222938 14 P05067 1 +Lamellar body 0.7082823337413331 1.4666020304688394 0.1424843473703392 1.0 0.4189039812687973 2 Q07065 1 +Phagophore assembly site 0.7884165048525573 1.4622839940778336 0.1436634027925767 1.0 0.4195732492154062 5 Q13501,Q5MNZ6 2 +Emc complex 0.7869817760017462 1.4568189992854153 0.1451663499271944 1.0 0.4203546495313829 5 Q5J8M3 1 +Trans golgi network 0.4767423335735424 1.4400655624251697 0.1498488510274713 1.0 0.4277239048745299 41 P05067,Q9BZH6,O14828,O15127,P51809,P04062,P11717,Q15334 8 +Ficolin 1 rich granule lumen 0.447903622152781 1.428295003172556 0.1532069654806274 1.0 0.4328747241725293 61 P08236,Q13510,P16278,P15586 4 +Cis golgi network 0.6921443689119389 1.419530404871964 0.1557444390523965 1.0 0.4328747241725293 8 P30533,P49755,P24390,O00461 4 +Contractile ring 0.7702388956405953 1.3668639504381648 0.1716679533395524 1.0 0.4655533245850219 4 Q9NQW6,O43663 2 +Intrinsic component of postsynaptic specialization membrane 0.7621915986755199 1.33578803912204 0.1816185635371159 1.0 0.4796035120950186 4 Q15375 1 +Intrinsic component of postsynaptic density membrane 0.7621915986755199 1.33578803912204 0.1816185635371159 1.0 0.4796035120950186 4 Q15375 1 +Sarcolemma 0.5216046078040307 1.3261422423086828 0.1847925862953472 1.0 0.4840065427177762 22 P11279,P05026,O75955,P24666,Q92542,P35613,P05556 7 +Caveola 0.6028102976876926 1.3257207698674205 0.1849322050973816 1.0 0.4840065427177762 12 Q14254,P05026,O75955,Q8WTV0,Q9UNF0,P23634 6 +External encapsulating structure 0.5193822171693407 1.313046817513804 0.1891671727890043 1.0 0.4892966728554452 22 Q08380 1 +Presynaptic active zone 0.582285555299458 1.3130309385322705 0.1891725231788059 1.0 0.4892966728554452 14 P05067 1 +Cell body membrane 0.7555102040816307 1.3064387130895938 0.1914034079769331 1.0 0.4908922746006038 3 P55011,P20020 2 +Plasma membrane raft 0.5614173615712615 1.3063298199577262 0.1914404204764914 1.0 0.4908922746006038 16 Q14254,P05026,O75955,Q8WTV0,Q9UNF0,P23634,P63167 7 +Ciliary membrane 0.7507827065391709 1.2917176830363355 0.1964549313757562 1.0 0.4960355818442992 4 O95721 1 +Cleavage furrow 0.6023610095048202 1.2861838669344992 0.1983789000899709 1.0 0.4970744030663476 11 P11233,Q16513,Q9UHB6,P35580,P05556,P35579 6 +Endoplasmic reticulum golgi intermediate compartment 0.4646104265154726 1.274890474880669 0.2023480109498228 1.0 0.5027350581908273 38 Q10472,P09429,O15258,Q15904,Q02818,Q9Y678,P80303,P30533,P24390,Q9Y282,Q03519,Q9BVK6,Q9Y217,Q12907 14 +Postsynaptic specialization membrane 0.6132010720828245 1.259690452888082 0.2077810507656035 1.0 0.5106636576238339 9 Q15375 1 +Autophagosome 0.5352892280654145 1.248300086094745 0.2119211826947711 1.0 0.5173110252466913 18 Q13501,Q96AX1,P11279,O95721,Q9Y3E7 5 +Manchette 0.6580987352101215 1.240975166082923 0.2146149230644076 1.0 0.5173110252466913 2 P62826 1 +Clathrin coat 0.5757917555297983 1.2388753183446612 0.2153916754025617 1.0 0.5174932709507909 13 P11717,Q8NC96 2 +Dendrite membrane 0.737551020408161 1.2358823817036924 0.2165022868263513 1.0 0.5174932709507909 3 P23634,P20020 2 +Sperm annulus 0.6560587515299888 1.231815820855866 0.2180178920498399 1.0 0.5183066867599967 2 Q15019 1 +Proteasome core complex beta subunit complex 0.6854238085256057 1.2230245958434698 0.2213204065925895 1.0 0.519859629638064 7 P49721 1 +Neuronal ribonucleoprotein granule 0.7330612244897937 1.2182582639747852 0.2231258448599837 1.0 0.519859629638064 3 O60828,Q06787 2 +Rough endoplasmic reticulum 0.473035971577437 1.2086214714248695 0.2268083035426711 1.0 0.5223740480167401 33 P05067,Q5BJF2 2 +Integral component of synaptic vesicle membrane 0.7248318799696354 1.1915219019013483 0.2334487637699376 1.0 0.5282133914783035 4 Q86Y82 1 +Autophagosome membrane 0.674332674597539 1.1793620915781329 0.2382540233233681 1.0 0.5330017194227158 7 O95721,P11279 2 +Excitatory synapse 0.7132765435912315 1.175208764151217 0.2399112047741702 1.0 0.5330017194227158 5 Q9UQB8 1 +Coated vesicle membrane 0.4388856965737576 1.167125643326466 0.2431596334275678 1.0 0.5348299169154984 45 P10321,P51809,P02786,Q8NC96,P11717,Q14108 6 +Sodium potassium exchanging atpase complex 0.7183053883754241 1.160409546632847 0.2458821017557042 1.0 0.5368020142290375 3 P05026 1 +Atpase dependent transmembrane transport complex 0.7183053883754241 1.160409546632847 0.2458821017557042 1.0 0.5368020142290375 3 P05026 1 +Cation transporting atpase complex 0.7183053883754241 1.160409546632847 0.2458821017557042 1.0 0.5368020142290375 3 P05026 1 +Plasma membrane region 0.377468775493396 1.1535490843982257 0.2486850829519411 1.0 0.5389052479806851 136 P05067,Q9H4M9,Q9UHB6,P02786,Q8NC96,P31751,O15439,Q06481,P61421,Q8WTV0,P05026,Q06787,Q9NVZ3,Q99523,P54709,Q15375,P51790,Q92542,P05556,P55011,Q96A49,Q9UQB8,Q15334,P11233,O95721,P08195,P08183,P35613 28 +Proteasome core complex 0.5483793494132454 1.1476171761387024 0.2511266359491957 1.0 0.5402285192858308 14 P28072,P49721 2 +Postsynaptic density membrane 0.6607791061774572 1.1260343571632618 0.2601509770216683 1.0 0.5520594158481296 7 Q15375 1 +Gap junction 0.6319869441044493 1.1240125945336932 0.2610076830030272 1.0 0.5520594158481296 2 Q07157 1 +Juxtaparanode region of axon 0.7034985030592535 1.1025228731936467 0.2702344200766702 1.0 0.5665952070194112 3 Q15334 1 +Intrinsic component of presynaptic membrane 0.6935583609752187 1.099976130058948 0.2713425222665524 1.0 0.5671187313722731 5 Q92542 1 +Wash complex 0.6238270093839274 1.0876312096174026 0.2767579471340295 1.0 0.5694345537943339 2 P47756 1 +Snare complex 0.5656374368497827 1.0850697889200838 0.2778907466961628 1.0 0.5694345537943339 10 P51809,Q99747,Q86Y82 3 +Filopodium 0.4678939352802119 1.0756803881269987 0.282070221415875 1.0 0.5694345537943339 25 P05067,Q9UQB8,P05556,Q06787 4 +Schaffer collateral ca1 synapse 0.5336342207634611 1.0755360363515647 0.2821348072654466 1.0 0.5694345537943339 14 Q15375,Q9UQB8 2 +Distal axon 0.4275787414159453 1.0718777867680878 0.2837749286330775 1.0 0.5711256624034659 44 P05067 1 +Myosin filament 0.692610147517002 1.0600998173807 0.289099190884388 1.0 0.5781983817687761 3 P35579 1 +Sperm connecting piece 0.6172990616075099 1.0586060139348354 0.2897792468882922 1.0 0.5782472754648729 2 P47756 1 +Copii coated er to golgi transport vesicle 0.469667253014219 1.0483399482292757 0.294482010474711 1.0 0.5849845343213854 23 P05067,P10321,P01889,Q9Y282,Q12907 5 +Cell division site 0.5193909500656154 1.0457344328695275 0.2956836606111248 1.0 0.5860516599078924 15 P11233,Q16513,Q9UHB6,Q9NQW6,P35580,P05556,P35579 7 +Neuron projection cytoplasm 0.4569692140696085 1.0384895811126382 0.2990421834028964 1.0 0.5900563887278628 29 Q00577,Q92572,Q14254,Q14168,Q9UH62,Q06787,Q9UQB8,O60828,Q9NUL3,O14617,O95239,P27695,Q15334 13 +Lumenal side of endoplasmic reticulum membrane 0.6328091898849394 1.016285027586762 0.3094936763378411 1.0 0.6002901228025096 7 P10321,P01889 2 +Pcg protein complex 0.6791251555318916 1.0159923853675257 0.3096330126440683 1.0 0.6002901228025096 4 Q14157,Q8IXK0 2 +Escrt complex 0.6812244897959155 1.0159074180710077 0.3096734760489137 1.0 0.6002901228025096 3 Q9Y3E7,Q8WUX9 2 +Endoplasmic reticulum golgi intermediate compartment membrane 0.4943712638578634 0.9921244982786968 0.3211367973002945 1.0 0.6078168566928321 17 Q10472,Q15904,Q03519,Q9Y282,Q9BVK6,Q12907 6 +Late endosome membrane 0.4537765952220622 0.9870913956116552 0.3235978355350715 1.0 0.6085571235435673 25 P11279,Q8IV08,O15118,P51790,Q14108 5 +Cell projection membrane 0.4108564568577555 0.9734447512903122 0.3303323064575298 1.0 0.6159684868827513 50 P55011,Q9H4M9,P15531,O95721,Q9UHB6,P31751,P51790,P05556,Q96AC1,P20020,Q06481 11 +Ruffle membrane 0.4460177901591525 0.9384373962091777 0.3480196753326217 1.0 0.6408211975853285 25 P51790,P31751,Q06481,P05556 4 +Apical plasma membrane 0.4284531055020618 0.935271751702373 0.3496482692585601 1.0 0.64206336057962 35 P55011,P61421,Q14254,P05026,O75955,P08195,O00165,P54709,O43865,P08183,O15439,P51790,P20020 13 +Scf ubiquitin ligase complex 0.6117832104186527 0.9342979916034306 0.3501502000439878 1.0 0.64206336057962 7 Q93034,Q13617,Q9HB71 3 +Sperm principal piece 0.654208361392353 0.9119646911076172 0.3617873050277724 1.0 0.6498908412107848 3 Q9BW83 1 +Septin cytoskeleton 0.651020408163262 0.8998042487799076 0.3682244328944235 1.0 0.6561089895209729 3 Q16181,Q15019 2 +Organelle subcompartment 0.3640268235218135 0.8969700227768532 0.369734913293078 1.0 0.6574721643639009 278 Q6UXD5,P05067,Q10472,O15127,Q8IV08,Q9Y282,Q5J8M3,P11717,Q14108,Q9BVK6,Q8TB61,Q15904,O14828,Q9UID3,Q96G23,Q99523,O00461,Q70UQ0,Q10471,P24390,Q5BJF2,O43852,P30519,Q9HD20,Q9UBM7,P51571,O75844,P10321,P49069,P51809,Q14849,P01889,Q6P179,Q9UM00,Q15392,P04062,Q6NUQ1,Q03519,O60568,O15269,Q15334,Q14739,Q12907,Q9BQE5,Q9BZH6,Q9Y678,P42345,P84095,O43865,Q8N4V1,P35606,P50402,O43464,P35613,Q9H8Y8 55 +Leading edge membrane 0.4251781841430511 0.8934791052712462 0.3716006567941838 1.0 0.6592806531360083 34 P15531,P31751,P51790,P05556,Q96AC1,P20020,Q06481 7 +Intrinsic component of mitochondrial inner membrane 0.4436990580755695 0.8908784488890459 0.3729943831234332 1.0 0.6592806531360083 23 O60830,O14925,Q99595 3 +Lamellipodium 0.3991544814021962 0.870360970039606 0.384103169077477 1.0 0.6695237057832701 49 P05067,Q9UHY1,Q9UQB8,P05556 4 +Nucleotide activated protein kinase complex 0.5675234598123262 0.8408496680166104 0.4004321582060826 1.0 0.6868767685351163 2 P10644 1 +Basolateral plasma membrane 0.425172898304757 0.8389771950801546 0.4014821069012404 1.0 0.6868767685351163 30 P55011,Q6P4Q7,P05026,O75955,P08195,P02786,P54709,O15439,P20020,P35613 10 +Brca1 a complex 0.6336937832615647 0.8341920968546899 0.4041727439281835 1.0 0.6871240482699781 3 P38398 1 +Myosin ii complex 0.6304614128215543 0.8325078917218944 0.4051223255646801 1.0 0.6871240482699781 4 P35580,P35579,P60660 3 +Basal part of cell 0.4081351159818732 0.8300500372696596 0.4065104937235466 1.0 0.6871240482699781 37 P55011,Q6P4Q7,P05026,O75955,P08195,P02786,P42785,P54709,O15439,P20020,P35613 11 +Intrinsic component of endoplasmic reticulum membrane 0.3955917228037823 0.8218678044485158 0.4111521384288212 1.0 0.6907355925604197 45 Q9UBM7,O75844,P10321,P49069,P01889,Q8N4V1,Q9Y282,Q03519,Q5J8M3,Q8TB61 10 +Mediator complex 0.6131437088634318 0.7981889816738391 0.424760830483148 1.0 0.7034184656383343 5 Q00534,Q9Y2X0,Q9Y2W1 3 +Actin based cell projection 0.4085494505917867 0.7936599472966986 0.4273934232738228 1.0 0.7045999987430126 35 P05067 1 +Photoreceptor inner segment 0.6181144123256022 0.7868982034892245 0.4313414592737781 1.0 0.7066357214446677 4 P35613 1 +Axon 0.3582751122727449 0.7734836860886619 0.4392361799469229 1.0 0.7147717909837379 90 P05067,P61421,Q96A49,Q06787,Q14203,P58546,P50897,P51790,Q9UH62,P35613,Q15334 11 +Receptor complex 0.4760451502809684 0.766159241777066 0.443581556783339 1.0 0.7205136889187937 13 P05067,P02786,Q15375,O43464,O00170,P05556 6 +Dynactin complex 0.6021623452224933 0.7581175755190325 0.4483805989468621 1.0 0.7256361252681328 5 P61163 1 +Cell leading edge 0.3502781500470281 0.729422510230827 0.4657432524028468 1.0 0.7468828156714744 95 P05067,Q9UHB6,P31751,Q96AC1,Q9Y217,Q06481,O75955,Q9Y5K6,Q9H2G2,P51790,P05556,O00571,Q14254,P15531,Q9UQB8,P51809,Q9UNF0,P20020,P35579,O00165,Q9UHY1 21 +Nuclear inner membrane 0.4455607117506909 0.7125723249756902 0.4761104420742104 1.0 0.7552687228587294 16 Q5JTV8,O75844,Q9Y2U8,P50402,Q5SNT2,Q14739 6 +Camp dependent protein kinase complex 0.5980624275727464 0.7024806887498315 0.4823794407030024 1.0 0.7611067382827337 3 P17612 1 +Ruffle 0.3758164955682177 0.6758162525890934 0.4991573145157062 1.0 0.77303454925389 48 Q9UQB8,P51790,Q9UHB6,Q06481 4 +Proton transporting two sector atpase complex 0.4193406159349276 0.6538497348637208 0.5132086205319812 1.0 0.779201203740362 19 Q93050,Q15904,Q9Y487 3 +Cell cell contact zone 0.4123548337221234 0.6462920094639109 0.5180902617359078 1.0 0.7811207023095226 20 Q14254,P05026,O75955,Q9UDY2,Q14126,Q92692,P05556 7 +Filopodium membrane 0.5120359037127774 0.6111528082563983 0.5410984221419468 1.0 0.8034491722713756 2 Q8WXH0 1 +Nuclear replication fork 0.4367689974175448 0.5868199654418157 0.5573246263087814 1.0 0.8233841212803102 13 Q9UNS1 1 +Flemming body 0.4255848986878792 0.5591737062949829 0.5760431760281501 1.0 0.8439702346458944 14 P11233,Q02241,P62826 3 +Intrinsic component of mitochondrial membrane 0.3746157160969295 0.5437637574586115 0.5866040518240274 1.0 0.8533341915216074 34 Q9UG56,Q99595,O14925,Q8IWA4,O60830,Q9UH62 6 +Synaptic vesicle membrane 0.4388145143151004 0.5385583528776141 0.590191630937976 1.0 0.8547602930825859 10 O43760,P61020,P20020,Q86Y82 4 +Intrinsic component of mitochondrial outer membrane 0.441186606169307 0.5307561519974558 0.595587768898546 1.0 0.8583470787067281 9 Q9UH62,Q8IWA4 2 +Chaperone complex 0.3904812612833823 0.5274881182515517 0.597854665393281 1.0 0.8602085071400879 20 Q15185,O95456 2 +Kinetochore microtubule 0.5332988577450606 0.5223021203553551 0.601459993113735 1.0 0.8625816486606736 6 Q9Y3E7,Q8WUX9,Q7Z460 3 +Organelle membrane contact site 0.4216514965890489 0.5202115828748968 0.6029161131118341 1.0 0.8632662528646716 13 O96008,Q14849 2 +Costamere 0.5262870743551703 0.4995609690032084 0.6173842465571961 1.0 0.8740496074854687 6 P51114 1 +Lateral element 0.5325607436582984 0.4894569786733329 0.6245182052674803 1.0 0.8771099634489133 4 P54132 1 +Neuron projection membrane 0.516584744690851 0.4646179562859137 0.6422050710408691 1.0 0.8920076734772387 5 P23634,P20020 2 +Swr1 complex 0.5153688458870623 0.4607715570936794 0.64496251012206 1.0 0.89302501401516 5 Q9GZN1 1 +Prefoldin complex 0.5213827003413534 0.4539503373610861 0.6498645719530374 1.0 0.8965702959307236 4 Q99471 1 +Copi coated vesicle 0.4120986570211903 0.4337234826354388 0.6644892520712264 1.0 0.9023865473264052 10 P49755,Q9Y678,P24390,P35606 4 +Prespliceosome 0.4053706564217625 0.3962365933107281 0.6919304982529182 1.0 0.923185787406325 9 Q15428,P26368 2 +Eukaryotic translation initiation factor 2 complex 0.5040816326530563 0.3897766771370461 0.6967016914081212 1.0 0.923185787406325 3 P05198,P20042 2 +Saga type complex 0.4990899554516276 0.3751769548806719 0.7075288678740828 1.0 0.923185787406325 3 Q9ULM3 1 +Photoreceptor outer segment 0.4936744820388224 0.3705050811007929 0.711006191346917 1.0 0.923185787406325 4 P35613 1 +T tubule 0.4545815685309052 0.3702225152523745 0.711216701858504 1.0 0.923185787406325 7 P23634,P30626,Q12955,P05026 4 +Guanyl nucleotide exchange factor complex 0.4964259508759838 0.3674883072122071 0.7132548121485625 1.0 0.923185787406325 3 Q6IAA8 1 +Nata complex 0.4443084455324367 0.3659674694115758 0.7143893498535143 1.0 0.923185787406325 2 Q9BXJ9 1 +Cytoplasmic side of membrane 0.3514568084457712 0.3638215906261619 0.7159912389701479 1.0 0.923185787406325 28 Q96A49,P24666,P17900,O43464,Q96AC1,P20020,Q15334 7 +Nuclear ubiquitin ligase complex 0.3896627620966379 0.3624159906184117 0.7170411917706345 1.0 0.923185787406325 11 Q8IXK0,P38398,Q16763 3 +Translation preinitiation complex 0.3737571983937709 0.3517485722256568 0.7250268300928426 1.0 0.9281185256050613 15 Q7Z478,Q9Y262,O75822,O15372,O75821 5 +Ccr4 not complex 0.446726451332566 0.3463276039478408 0.7290965257809225 1.0 0.9293445957817574 7 Q9H9A5,Q9ULM6 2 +Synaptonemal structure 0.4118552158884085 0.3251882378091721 0.7450386102118003 1.0 0.9345603448073444 8 P54132,P38398 2 +Presynaptic membrane 0.3721091416350604 0.3167681648682929 0.751419521905206 1.0 0.9363789933393578 13 Q96A49,Q92542,Q06787 3 +Proton transporting two sector atpase complex proton transporting domain 0.381860672626036 0.3150643193395486 0.7527128189088488 1.0 0.9363789933393578 9 Q93050,Q9Y487 2 +Endoplasmic reticulum tubular network 0.378829558173246 0.3050879110411842 0.7602991981636149 1.0 0.9405858001600372 9 Q12797,Q8NHH9,Q9NQC3,P50402 4 +Intercalated disc 0.3708389760357899 0.3020775622926014 0.7625929366217401 1.0 0.9407090490914332 12 Q14126,P05556 2 +Nuclear outer membrane endoplasmic reticulum membrane network 0.3327264951870795 0.2925253328929406 0.7698849936568872 1.0 0.943018171528568 238 Q6UXD5,Q10472,Q8IV08,Q9Y282,Q5J8M3,Q9BVK6,Q14108,Q8TB61,Q15904,Q96G23,Q99523,Q70UQ0,Q10471,P24390,Q5BJF2,O43852,P30519,Q9HD20,Q9UBM7,P51571,O75844,P10321,P49069,P51809,Q14849,P01889,Q6P179,Q9UM00,Q15392,Q6NUQ1,Q03519,O60568,O15269,Q12907,Q14739,Q9BQE5,Q9Y678,P42345,P84095,O43865,Q8N4V1,P35606,P50402,O43464,P35613,Q9H8Y8 46 +Esc e z complex 0.4198286413708698 0.2914203206414275 0.7707298750347393 1.0 0.943018171528568 2 Q92769 1 +Commitment complex 0.4569143691411665 0.2912240973776763 0.7708799338685912 1.0 0.943018171528568 5 P26368 1 +Neuron projection 0.3198062725236419 0.2895103843302273 0.7721908344363053 1.0 0.9432256571776751 160 P05067,P17655,P58546,Q14444,P50897,Q15555,P27695,Q14651,Q16637,Q00577,P61421,Q9UPT5,Q06787,Q9H269,Q14247,Q9Y5K6,Q9NUL3,Q15375,P51790,Q66K74,P05556,P55011,Q96A49,Q14254,Q9UQB8,Q14203,P51809,O14617,P51114,O60828,P20020,Q15334,P52294,Q92572,P42345,Q9UH62,P35613 37 +Cytoplasmic region 0.325103224513462 0.287469041512284 0.7737532032913665 1.0 0.9432256571776751 50 Q14168,Q7Z460,Q99729,Q15555,P27695,Q00577,Q06787,Q9NUL3,Q14254,Q9UQB8,P61163,Q14203,O14617,O95239,O60828,Q15334,Q92572,Q9BZH6,Q9UH62,P17612,Q15019 21 +Cell cell junction 0.3129221124665979 0.2812280873043993 0.7785354630672874 1.0 0.9432256571776751 84 P05067,Q13177,O96013,Q92692,Q96AC1,Q9NYL9,P05026,O75955,Q96HC4,Q9Y5K6,P05556,Q14254,Q14126,Q9UQB8,Q9Y624,Q9UNF0,P35579,Q9C0C2,Q9UDY2,Q16625 20 +Copi coated vesicle membrane 0.3691210258823306 0.2739560005161003 0.7841184349699108 1.0 0.9453167551795396 9 Q9Y678,P24390,P35606,P48444 4 +Outer mitochondrial membrane protein complex 0.3492208215919916 0.2668052371002336 0.7896191217607058 1.0 0.9488338765571424 16 Q8IWA4,O96008,Q8N4H5 3 +Dendrite terminus 0.4538775510204026 0.2553025321472938 0.7984894443632677 1.0 0.9534191770350364 3 P08238,P07900 2 +Dendritic growth cone 0.4538775510204026 0.2553025321472938 0.7984894443632677 1.0 0.9534191770350364 3 P08238,P07900 2 +Pseudopodium 0.4365467967174069 0.2437781909644068 0.8074026119300486 1.0 0.9558779915735608 6 P51809 1 +Cell trailing edge 0.4312508262550013 0.2311957415933764 0.8171627381152899 1.0 0.965029490840974 6 Q14254,O75955 2 +Ino80 type complex 0.4051282570621672 0.2309921567242496 0.8173208953040902 1.0 0.965029490840974 7 Q9GZN1 1 +Cop9 signalosome 0.3527004909983607 0.224342927242196 0.8224904762300269 1.0 0.9672488000465116 9 Q9UNS2,Q9UBW8,Q9BT78,P61201,Q92905,Q99627,Q13098,P62993 8 +Flotillin complex 0.4232028864725534 0.212703890260799 0.8315579322119617 1.0 0.9707521313868354 6 O75955 1 +Pore complex 0.3721881390593016 0.2108899175708186 0.8329731718164999 1.0 0.9707521313868354 8 P12235,P21796,P30405,P55196,Q9Y277,P45880,O96008 7 +Eukaryotic translation initiation factor 3 complex 0.3398933989339959 0.2085284007709115 0.8348164094041206 1.0 0.9707521313868354 14 Q13347,Q7L2H7,O15371,Q9Y262,O75822,P60228,Q92905,O15372,O75821,P56537,P55884,Q9UBQ5,Q14152 13 +Adherens junction 0.3163175065542599 0.1956981813523339 0.8448464079588889 1.0 0.9766114440625688 37 Q9NYL9,Q9C0C2,Q14254,O75955,Q9UDY2,O96013,Q92692,Q9UQB8,Q96HC4,Q96AC1 10 +Cilium 0.3010407224383229 0.1934772091128652 0.8465852533241254 1.0 0.9773405673192128 70 Q13501,P05067,Q9BW83,P05026,Q9H4M9,Q9BZH6,O95721,Q14203,P48729,P35613,P54709,A6NIH7,Q9NUQ9 13 +Nuclear exosome rnase complex 0.3890366231284952 0.1920508295712998 0.8477023901726337 1.0 0.977350991022566 7 Q9Y2L1,Q15024,Q9Y3B2 3 +Messenger ribonucleoprotein complex 0.4055467445444832 0.1727670988715365 0.8628344994007711 1.0 0.9888860527850416 5 Q9NUL3,Q06787 2 +Chromatin silencing complex 0.4041683694319626 0.1720948971521206 0.8633629243973682 1.0 0.9888860527850416 6 Q15022,Q9UIF9,Q13185,O60264,Q8IXJ6 5 +Beta catenin destruction complex 0.4041832320334515 0.1700728898193857 0.864952813679216 1.0 0.9888860527850416 5 P48729 1 +Integral component of presynaptic active zone membrane 0.4082047461183322 0.1650442761420119 0.8689091325672365 1.0 0.9888860527850416 4 P20020 1 +Intrinsic component of presynaptic active zone membrane 0.4082047461183322 0.1650442761420119 0.8689091325672365 1.0 0.9888860527850416 4 P20020 1 +Presynaptic active zone membrane 0.4082047461183322 0.1650442761420119 0.8689091325672365 1.0 0.9888860527850416 4 P20020 1 +Ciliary tip 0.3885700873084629 0.1409672131003943 0.8878958438068454 1.0 1.0 5 Q9BW83,A0AVF1,Q15555 3 +Mismatch repair complex 0.3963265306122401 0.1396936362429354 0.8889020546466575 1.0 1.0 3 P52701,P20585 2 +Clathrin vesicle coat 0.3203283844199029 0.1390048882491143 0.8894462862878336 1.0 1.0 9 Q8NC96 1 +Eukaryotic translation initiation factor 3 complex eif3m 0.3390593047034671 0.132529729662855 0.8945653095454367 1.0 1.0 8 Q13347,Q7L2H7,O15371,O15372,P55884,P56537,Q14152 7 +Rna polymerase iii complex 0.3788444829146558 0.1158140840097972 0.907799888204041 1.0 1.0 4 O14802,O15160 2 +Chromocenter 0.3696456295017361 0.1100312995442506 0.9123845521680698 1.0 1.0 5 P83916 1 +Microtubule associated complex 0.3030022131669755 0.1065997688767229 0.9151065019507728 1.0 1.0 35 Q9NSK0,Q96P70,P61163,Q14203,O94927,Q15555,Q9UJW0,Q9BW19,Q66K74,P49356 10 +Intrinsic component of synaptic vesicle membrane 0.3249034795572124 0.1042932800771765 0.916936610554444 1.0 1.0 8 P20020,Q86Y82 2 +Ciliary plasm 0.3069633911283334 0.1042291807170351 0.916987477220938 1.0 1.0 11 P17612,Q9BZH6,Q15555 3 +Rna polymerase ii transcription repressor complex 0.3304773561811499 0.1029042312990709 0.9180389794407884 1.0 1.0 2 Q9UHI6 1 +Sperm head 0.3706122448979543 0.102462578921375 0.9183895141731472 1.0 1.0 3 P08238,P25685 2 +Rpap3 r2tp prefoldin like complex 0.3599583889683648 0.0955902105423754 0.9238460404506216 1.0 1.0 6 P19388,Q9UHV9 2 +9plus2 motile cilium 0.2952606596961737 0.084193695967409 0.9329024302829616 1.0 1.0 22 Q13501,Q9BW83,P05026,P54709,P23634,P17612,P62826,P00568 8 +Mitochondria associated endoplasmic reticulum membrane 0.3102835071327659 0.0785331446470797 0.937403966013125 1.0 1.0 8 O96008 1 +R2tp complex 0.3489795918367293 0.0778306951185712 0.9379627293270572 1.0 1.0 3 Q9Y230,Q9H6T3 2 +Ino80 complex 0.3491220906492425 0.0775481707014187 0.9381874719387368 1.0 1.0 4 Q9Y5K5,Q9Y230,O96019 3 +Spectrin associated cytoskeleton 0.3444897959183621 0.073443769850901 0.9414529883137496 1.0 1.0 3 Q12955,P11171 2 +Endolysosome membrane 0.3406862745098057 0.0718194608427406 0.9427455852993872 1.0 1.0 5 Q00610,O95782,Q96CW1,P63010 4 +Clathrin coat of endocytic vesicle 0.3405471621069865 0.0685775199976897 0.9453259131745884 1.0 1.0 4 O95782,Q96CW1,P63010 3 +Perinuclear endoplasmic reticulum 0.3336185295009958 0.0641136389397006 0.9488797418868224 1.0 1.0 5 P22059,P17655 2 +Catalytic step 1 spliceosome 0.3289742541888106 0.0569573065610635 0.9545792043271624 1.0 1.0 6 P38919,Q9NW64,O75643,Q9Y5S9,Q9UMS4 5 +Copi vesicle coat 0.2959658678856903 0.0566473645993167 0.9548261035998282 1.0 1.0 8 Q9Y678,P48444,P35606 3 +Condensin complex 0.3259803921568649 0.056467700596252 0.9549692256445204 1.0 1.0 5 Q15021,Q9NTJ3,O95347,Q9BPX3 4 +Vesicle tethering complex 0.2879003803330979 0.0556336216966001 0.9556336797316696 1.0 1.0 16 Q96AX1,Q5VIR6,Q9UPT5,Q7Z392,Q9UID3,Q6NUQ1 6 +Golgi associated vesicle membrane 0.2853801958449429 0.0526501370092944 0.9580106687811858 1.0 1.0 12 Q9Y678,P24390,P35606 3 +Annulate lamellae 0.3146938775510164 0.0500827418647985 0.960056452474782 1.0 1.0 3 P49792,P63241 2 +Replication fork 0.2897360631384933 0.045573081730593 0.9636505245401944 1.0 1.0 28 P54132,Q9UNS1 2 +Proteasome regulatory particle base subcomplex 0.2700490998363339 0.0429751717195764 0.9657213256612324 1.0 1.0 9 Q99460,Q13200,P62333,P17980,P62195,P55036,P43686,P62191 8 +9plus0 non motile cilium 0.3142813402575228 0.0427267672097663 0.9659193419011916 1.0 1.0 6 P35613 1 +Pericentric heterochromatin 0.2663535713491611 0.0377113195967074 0.969917850684707 1.0 1.0 9 P26358,P45973,Q13185,P83916 4 +Clathrin adaptor complex 0.2927228127555236 0.0348808618859393 0.972174741328658 1.0 1.0 7 P63010,Q9Y2T2,O94973,O00203,O95782,Q96CW1 6 +Specific granule membrane 0.2609645708357286 0.0219424816382199 0.9824938374757426 1.0 1.0 10 P30519,Q07065,Q6IAA8 3 +Integrator complex 0.2409146590445124 0.0169845427555367 0.9864489470888304 1.0 1.0 4 Q68E01,Q6KC79,Q96SY0 3 +Nuclear pore central transport channel 0.2037566353613757 0.0129311188732657 0.9896827474291447 1.0 1.0 4 Q8NFH5,P37198,Q7Z3B4 3 +Clathrin coat of coated pit 0.2639967306906452 0.0110497129113028 0.9911837840714774 1.0 1.0 6 P63010,O94973,Q00610,O95782,Q96CW1 5 +Cytoplasmic exosome rnase complex 0.2497494977415612 0.007224898245109 0.9942354153879732 1.0 1.0 8 Q9Y2L1,Q15024 2 +Dynein complex 0.2443982902590758 0.0033872685119528 0.9972973559191908 1.0 1.0 8 Q9UJW0,Q14203,P63167 3 +Dna polymerase complex 0.246933769419465 0.0029143967987234 0.9976746510820518 1.0 1.0 7 P49642,Q07864,P25205,P49643,Q9Y2S7,Q9NRG0 6 +Proteasome regulatory particle lid subcomplex 0.246116107931319 0.0025380534134126 0.9979749285411008 1.0 1.0 7 O00231,Q9UNM6,O43242,O00487,O00232,Q16186 6 +Microtubule end 0.2421030440302523 0.0018466953394099 0.998526551137658 1.0 1.0 8 Q14203,Q15691,Q15555 3 +Microtubule plus end 0.2421030440302523 0.0018466953394099 0.998526551137658 1.0 1.0 8 Q14203,Q15691,Q15555 3 diff --git a/msigdb_gocc/selections.json b/msigdb_gocc/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..82ca8af5990127fa4a64be3c6f0893433071c3a2 --- /dev/null +++ b/msigdb_gocc/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["90s preribosome", "9plus0 non motile cilium", "9plus2 motile cilium", "A band", "Acrosomal membrane", "Acrosomal vesicle", "Actin based cell projection", "Actin cytoskeleton", "Actin filament", "Actin filament bundle", "Actomyosin", "Adherens junction", "Aggresome", "Alpha dna polymerase primase complex", "Alveolar lamellar body", "Aminoacyl trna synthetase multienzyme complex", "Ampa glutamate receptor complex", "Amphisome", "Amphisome membrane", "Anaphase promoting complex", "Anchored component of membrane", "Anchored component of plasma membrane", "Anchored component of postsynaptic membrane", "Anchored component of synaptic membrane", "Anchored component of synaptic vesicle membrane", "Anchoring junction", "Annulate lamellae", "Ap 1 adaptor complex", "Ap 3 adaptor complex", "Ap type membrane coat adaptor complex", "Apical dendrite", "Apical junction complex", "Apical part of cell", "Apical plasma membrane", "Apicolateral plasma membrane", "Arp2 3 protein complex", "Aryl hydrocarbon receptor complex", "Aster", "Astrocyte end foot", "Astrocyte projection", "Atac complex", "Atpase complex", "Atpase dependent transmembrane transport complex", "Autolysosome", "Autophagosome", "Autophagosome membrane", "Axolemma", "Axon", "Axon cytoplasm", "Axon hillock", "Axon initial segment", "Axonal growth cone", "Azurophil granule", "Azurophil granule lumen", "Azurophil granule membrane", "B wich complex", "Barr body", "Basal cortex", "Basal dendrite", "Basal part of cell", "Basement membrane", "Basolateral plasma membrane", "Bcl 2 family protein complex", "Beta catenin destruction complex", "Beta catenin tcf complex", "Bleb", "Bloc complex", "Blood microparticle", "Box c d rnp complex", "Box h aca rnp complex", "Box h aca snornp complex", "Box h aca telomerase rnp complex", "Brca1 a complex", "Brca1 c complex", "Brisc complex", "Brush border", "Brush border membrane", "Cajal body", "Calcium and calmodulin dependent protein kinase complex", "Calcium channel complex", "Camp dependent protein kinase complex", "Carboxy terminal domain protein kinase complex", "Caspase complex", "Catalytic complex", "Catalytic step 1 spliceosome", "Catalytic step 2 spliceosome", "Catenin complex", "Cation channel complex", "Cation transporting atpase complex", "Caveola", "Ccaat binding factor complex", "Ccr4 not complex", "Ccr4 not core complex", "Cd40 receptor complex", "Cd95 death inducing signaling complex", "Cdc73 paf1 complex", "Cell body", "Cell body membrane", "Cell cell contact zone", "Cell cell junction", "Cell cortex", "Cell cortex region", "Cell division site", "Cell leading edge", "Cell pole", "Cell projection membrane", "Cell substrate junction", "Cell surface", "Cell tip", "Cell trailing edge", "Central element", "Centriolar satellite", "Centriolar subdistal appendage", "Centriole", "Centrosome", "Cerebellar mossy fiber", "Chaperone complex", "Chaperonin containing t complex", "Chitosome", "Chloride channel complex", "Cholinergic synapse", "Chromaffin granule", "Chromaffin granule membrane", "Chromatin", "Chromatin silencing complex", "Chromatoid body", "Chromocenter", "Chromosomal region", "Chromosome", "Chromosome centromeric core domain", "Chromosome centromeric region", "Chromosome passenger complex", "Chromosome telomeric region", "Chromosome telomeric repeat region", "Cia complex", "Ciliary basal body", "Ciliary base", "Ciliary membrane", "Ciliary plasm", "Ciliary rootlet", "Ciliary tip", "Ciliary transition zone", "Cilium", "Cis golgi network", "Cis golgi network membrane", "Clathrin adaptor complex", "Clathrin coat", "Clathrin coat of coated pit", "Clathrin coat of endocytic vesicle", "Clathrin coated endocytic vesicle", "Clathrin coated endocytic vesicle membrane", "Clathrin coated pit", "Clathrin coated vesicle", "Clathrin coated vesicle membrane", "Clathrin complex", "Clathrin sculpted gamma aminobutyric acid transport vesicle", "Clathrin sculpted vesicle", "Clathrin vesicle coat", "Cleavage furrow", "Cluster of actin based cell projections", "Coated vesicle", "Coated vesicle membrane", "Cohesin complex", "Collagen containing extracellular matrix", "Collagen trimer", "Commitment complex", "Compact myelin", "Condensed chromosome", "Condensed chromosome centromeric region", "Condensed nuclear chromosome", "Condensin complex", "Contractile fiber", "Contractile ring", "Cop9 signalosome", "Copi coated vesicle", "Copi coated vesicle membrane", "Copi vesicle coat", "Copii coated er to golgi transport vesicle", "Copii vesicle coat", "Core mediator complex", "Cornified envelope", "Cortical actin cytoskeleton", "Cortical cytoskeleton", "Cortical endoplasmic reticulum", "Cortical granule", "Costamere", "Crd mediated mrna stability complex", "Ctf18 rfc like complex", "Cul2 ring ubiquitin ligase complex", "Cul3 ring ubiquitin ligase complex", "Cul4 ring e3 ubiquitin ligase complex", "Cul4a ring e3 ubiquitin ligase complex", "Cul4b ring e3 ubiquitin ligase complex", "Cul5 ring ubiquitin ligase complex", "Cullin ring ubiquitin ligase complex", "Cuticular plate", "Cyclin a2 cdk2 complex", "Cyclin cdk positive transcription elongation factor complex", "Cyclin dependent protein kinase holoenzyme complex", "Cytochrome complex", "Cytolytic granule", "Cytoplasmic dynein complex", "Cytoplasmic exosome rnase complex", "Cytoplasmic microtubule", "Cytoplasmic region", "Cytoplasmic side of endoplasmic reticulum membrane", "Cytoplasmic side of endosome membrane", "Cytoplasmic side of lysosomal membrane", "Cytoplasmic side of membrane", "Cytoplasmic stress granule", "Cytoplasmic ubiquitin ligase complex", "Cytoskeleton of presynaptic active zone", "Cytosolic large ribosomal subunit", "Cytosolic region", "Cytosolic ribosome", "Cytosolic small ribosomal subunit", "Death inducing signaling complex", "Dendrite cytoplasm", "Dendrite membrane", "Dendrite terminus", "Dendritic growth cone", "Dendritic shaft", "Dendritic spine membrane", "Dendritic tree", "Dense body", "Dense core granule", "Dentate gyrus mossy fiber", "Derlin 1 retrotranslocation complex", "Desmosome", "Dihydrolipoyl dehydrogenase complex", "Distal axon", "Dna packaging complex", "Dna polymerase complex", "Dna repair complex", "Dna replication factor c complex", "Dna replication preinitiation complex", "Dopaminergic synapse", "Dynactin complex", "Dynein axonemal particle", "Dynein complex", "Dystrophin associated glycoprotein complex", "Early endosome", "Early endosome lumen", "Early endosome membrane", "Early phagosome", "Elongator holoenzyme complex", "Elongin complex", "Emc complex", "Endocytic vesicle", "Endocytic vesicle lumen", "Endocytic vesicle membrane", "Endolysosome", "Endolysosome lumen", "Endolysosome membrane", "Endopeptidase complex", "Endoplasmic reticulum", "Endoplasmic reticulum chaperone complex", "Endoplasmic reticulum exit site", "Endoplasmic reticulum golgi intermediate compartment", "Endoplasmic reticulum golgi intermediate compartment membrane", "Endoplasmic reticulum lumen", "Endoplasmic reticulum palmitoyltransferase complex", "Endoplasmic reticulum plasma membrane contact site", "Endoplasmic reticulum protein containing complex", "Endoplasmic reticulum quality control compartment", "Endoplasmic reticulum tubular network", "Endoplasmic reticulum tubular network membrane", "Endoribonuclease complex", "Endosome", "Endosome lumen", "Endosome membrane", "Envelope", "Enzyme activator complex", "Epsilon dna polymerase complex", "Equatorial microtubule organizing center", "Er membrane insertion complex", "Er to golgi transport vesicle membrane", "Er ubiquitin ligase complex", "Esc e z complex", "Escrt complex", "Escrt i complex", "Escrt iii complex", "Euchromatin", "Eukaryotic translation initiation factor 2 complex", "Eukaryotic translation initiation factor 2b complex", "Eukaryotic translation initiation factor 3 complex", "Eukaryotic translation initiation factor 3 complex eif3m", "Eukaryotic translation initiation factor 4f complex", "Excitatory synapse", "Exocyst", "Exocytic vesicle", "Exon exon junction complex", "Exoribonuclease complex", "External encapsulating structure", "External side of apical plasma membrane", "External side of plasma membrane", "Extrinsic component of cytoplasmic side of plasma membrane", "Extrinsic component of endoplasmic reticulum membrane", "Extrinsic component of endosome membrane", "Extrinsic component of external side of plasma membrane", "Extrinsic component of membrane", "Extrinsic component of mitochondrial inner membrane", "Extrinsic component of organelle membrane", "Extrinsic component of plasma membrane", "Extrinsic component of postsynaptic membrane", "Extrinsic component of postsynaptic specialization membrane", "Extrinsic component of synaptic membrane", "F actin capping protein complex", "Fascia adherens", "Female germ cell nucleus", "Female pronucleus", "Fibrillar center", "Ficolin 1 rich granule", "Ficolin 1 rich granule lumen", "Ficolin 1 rich granule membrane", "Filamentous actin", "Filopodium", "Filopodium membrane", "Filopodium tip", "Filtration diaphragm", "Flemming body", "Flotillin complex", "Gaba ergic synapse", "Gamma secretase complex", "Gamma tubulin complex", "Gamma tubulin large complex", "Gap junction", "Gator2 complex", "Gemini of coiled bodies", "Germ cell nucleus", "Glial cell projection", "Glutamatergic synapse", "Glycinergic synapse", "Glycogen granule", "Glycoprotein complex", "Golgi apparatus", "Golgi apparatus subcompartment", "Golgi associated vesicle", "Golgi associated vesicle membrane", "Golgi cis cisterna", "Golgi cisterna", "Golgi cisterna membrane", "Golgi lumen", "Golgi medial cisterna", "Golgi membrane", "Golgi stack", "Golgi transport complex", "Gpi anchor transamidase complex", "Granular component", "Growth cone membrane", "Gtpase complex", "Guanyl nucleotide exchange factor complex", "H4 h2a histone acetyltransferase complex", "H4 histone acetyltransferase complex", "Haus complex", "Hemidesmosome", "Hemoglobin complex", "Heterochromatin", "Hfe transferrin receptor complex", "High density lipoprotein particle", "Hippocampal mossy fiber", "Hippocampal mossy fiber to ca3 synapse", "Histone deacetylase complex", "Histone methyltransferase complex", "Histone pre mrna 3 end processing complex", "Hops complex", "Host cellular component", "Hrd1p ubiquitin ligase erad l complex", "Hulc complex", "I band", "Ikappab kinase complex", "Immunological synapse", "Inclusion body", "Inflammasome complex", "Inhibitory synapse", "Inner mitochondrial membrane protein complex", "Ino80 complex", "Ino80 type complex", "Insulin responsive compartment", "Integral component of cytoplasmic side of endoplasmic reticulum membrane", "Integral component of lysosomal membrane", "Integral component of presynaptic active zone membrane", "Integral component of synaptic vesicle membrane", "Integrator complex", "Integrin complex", "Intercalated disc", "Intercellular bridge", "Intercellular canaliculus", "Intermediate filament", "Intermediate filament cytoskeleton", "Intracellular protein containing complex", "Intraciliary transport particle", "Intraciliary transport particle a", "Intraciliary transport particle b", "Intrinsic component of endoplasmic reticulum membrane", "Intrinsic component of golgi membrane", "Intrinsic component of mitochondrial inner membrane", "Intrinsic component of mitochondrial membrane", "Intrinsic component of mitochondrial outer membrane", "Intrinsic component of nuclear inner membrane", "Intrinsic component of organelle membrane", "Intrinsic component of peroxisomal membrane", "Intrinsic component of plasma membrane", "Intrinsic component of postsynaptic density membrane", "Intrinsic component of postsynaptic membrane", "Intrinsic component of postsynaptic specialization membrane", "Intrinsic component of presynaptic active zone membrane", "Intrinsic component of presynaptic membrane", "Intrinsic component of synaptic membrane", "Intrinsic component of synaptic vesicle membrane", "Intrinsic component of vacuolar membrane", "Ion channel complex", "Iron sulfur cluster assembly complex", "Iswi type complex", "Juxtaparanode region of axon", "Keratin filament", "Kinesin complex", "Kinetochore microtubule", "Lamellar body", "Lamellipodium", "Lamellipodium membrane", "Lamin filament", "Large ribosomal subunit", "Late endosome", "Late endosome membrane", "Lateral element", "Lateral part of cell", "Lateral plasma membrane", "Leading edge membrane", "Lewy body", "Lipid droplet", "Lipopolysaccharide receptor complex", "Low density lipoprotein particle", "Lsm1 7 pat1 complex", "Lsm2 8 complex", "Lumenal side of endoplasmic reticulum membrane", "Lumenal side of membrane", "Lysosomal lumen", "M band", "Magnesium dependent protein serine threonine phosphatase complex", "Main axon", "Male germ cell nucleus", "Male pronucleus", "Manchette", "Mcm complex", "Mcrd mediated mrna stability complex", "Mediator complex", "Meiotic cohesin complex", "Meiotic spindle", "Membrane coat", "Membrane microdomain", "Membrane protein complex", "Messenger ribonucleoprotein complex", "Methylosome", "Methyltransferase complex", "Mhc class i peptide loading complex", "Mhc class i protein complex", "Mhc protein complex", "Mib complex", "Micos complex", "Microbody", "Microbody lumen", "Microbody membrane", "Microtubule", "Microtubule associated complex", "Microtubule bundle", "Microtubule cytoskeleton", "Microtubule end", "Microtubule minus end", "Microtubule organizing center", "Microtubule organizing center attachment site", "Microtubule plus end", "Microvillus", "Microvillus membrane", "Midbody", "Mismatch repair complex", "Mitochondria associated endoplasmic reticulum membrane", "Mitochondrial alpha ketoglutarate dehydrogenase complex", "Mitochondrial crista", "Mitochondrial envelope", "Mitochondrial intermembrane space protein transporter complex", "Mitochondrial large ribosomal subunit", "Mitochondrial matrix", "Mitochondrial permeability transition pore complex", "Mitochondrial protein containing complex", "Mitochondrial proton transporting atp synthase complex coupling factor f o", "Mitochondrial pyruvate dehydrogenase complex", "Mitochondrial small ribosomal subunit", "Mitochondrial tricarboxylic acid cycle enzyme complex", "Mitochondrion", "Mitotic cohesin complex", "Mitotic spindle", "Mitotic spindle astral microtubule", "Mitotic spindle microtubule", "Mitotic spindle midzone", "Mitotic spindle pole", "Mll1 2 complex", "Mll3 4 complex", "Mmxd complex", "Motile cilium", "Mpp7 dlg1 lin7 complex", "Mrna cleavage and polyadenylation specificity factor complex", "Mrna cleavage factor complex", "Mrna editing complex", "Multimeric ribonuclease p complex", "Multivesicular body", "Multivesicular body membrane", "Myelin sheath", "Myelin sheath abaxonal region", "Myelin sheath adaxonal region", "Myofilament", "Myosin complex", "Myosin filament", "Myosin ii complex", "N terminal protein acetyltransferase complex", "Nadh dehydrogenase complex", "Nascent polypeptide associated complex", "Nata complex", "Nbaf complex", "Neurofibrillary tangle", "Neurofilament", "Neuromuscular junction", "Neuron projection", "Neuron projection cytoplasm", "Neuron projection membrane", "Neuron projection terminus", "Neuron spine", "Neuron to neuron synapse", "Neuronal dense core vesicle", "Neuronal ribonucleoprotein granule", "Neurotransmitter receptor complex", "Nlrp3 inflammasome complex", "Nls dependent protein nuclear import complex", "Node of ranvier", "Non motile cilium", "Nonhomologous end joining complex", "Npbaf complex", "Nsl complex", "Nuclear body", "Nuclear chromosome", "Nuclear cyclin dependent protein kinase holoenzyme complex", "Nuclear envelope", "Nuclear envelope lumen", "Nuclear exosome rnase complex", "Nuclear inclusion body", "Nuclear inner membrane", "Nuclear lamina", "Nuclear membrane", "Nuclear outer membrane", "Nuclear outer membrane endoplasmic reticulum membrane network", "Nuclear periphery", "Nuclear pore", "Nuclear pore central transport channel", "Nuclear pore nuclear basket", "Nuclear pore outer ring", "Nuclear protein containing complex", "Nuclear replication fork", "Nuclear rna export factor complex", "Nuclear speck", "Nuclear stress granule", "Nuclear ubiquitin ligase complex", "Nucleocytoplasmic transport complex", "Nucleoid", "Nucleolar ribonuclease p complex", "Nucleolus", "Nucleotide activated protein kinase complex", "Nucleotide excision repair complex", "Nurd complex", "Nurf complex", "Oligosaccharyltransferase complex", "Organellar ribosome", "Organelle envelope lumen", "Organelle inner membrane", "Organelle membrane contact site", "Organelle subcompartment", "Origin recognition complex", "Outer dense fiber", "Outer kinetochore", "Outer membrane", "Outer mitochondrial membrane protein complex", "Oxidoreductase complex", "Oxoglutarate dehydrogenase complex", "P body", "Palmitoyltransferase complex", "Pam complex tim23 associated import motor", "Parallel fiber to purkinje cell synapse", "Paranodal junction", "Paranode region of axon", "Paraspeckles", "Pcg protein complex", "Peptidase complex", "Peptidase inhibitor complex", "Pericentric heterochromatin", "Pericentriolar material", "Periciliary membrane compartment", "Perikaryon", "Perinuclear endoplasmic reticulum", "Perinuclear region of cytoplasm", "Perinucleolar compartment", "Phagocytic cup", "Phagocytic vesicle", "Phagocytic vesicle membrane", "Phagolysosome", "Phagophore assembly site", "Phagophore assembly site membrane", "Phosphatase complex", "Photoreceptor connecting cilium", "Photoreceptor inner segment", "Photoreceptor outer segment", "Photoreceptor ribbon synapse", "Pi body", "Picln sm protein complex", "Pigment granule", "Pinosome", "Pip body", "Plasma membrane protein complex", "Plasma membrane raft", "Plasma membrane region", "Plasma membrane signaling receptor complex", "Platelet alpha granule", "Platelet alpha granule lumen", "Platelet alpha granule membrane", "Platelet dense granule", "Platelet dense granule lumen", "Platelet dense granule membrane", "Platelet dense tubular network", "Platelet dense tubular network membrane", "Pml body", "Podosome", "Polar microtubule", "Pole plasm", "Polymeric cytoskeletal fiber", "Polysomal ribosome", "Polysome", "Pore complex", "Post mrna release spliceosomal complex", "Postsynapse", "Postsynaptic cytoskeleton", "Postsynaptic cytosol", "Postsynaptic density intracellular component", "Postsynaptic density membrane", "Postsynaptic endosome", "Postsynaptic membrane", "Postsynaptic recycling endosome", "Postsynaptic specialization intracellular component", "Postsynaptic specialization membrane", "Prc1 complex", "Pre snornp complex", "Precatalytic spliceosome", "Prefoldin complex", "Preribosome", "Preribosome large subunit precursor", "Preribosome small subunit precursor", "Prespliceosome", "Presynapse", "Presynaptic active zone", "Presynaptic active zone cytoplasmic component", "Presynaptic active zone membrane", "Presynaptic cytoskeleton", "Presynaptic cytosol", "Presynaptic endocytic zone", "Presynaptic membrane", "Pronucleus", "Protease inhibitor complex", "Proteasome accessory complex", "Proteasome complex", "Proteasome core complex", "Proteasome core complex alpha subunit complex", "Proteasome core complex beta subunit complex", "Proteasome regulatory particle", "Proteasome regulatory particle base subcomplex", "Proteasome regulatory particle lid subcomplex", "Protein acetyltransferase complex", "Protein complex involved in cell adhesion", "Protein dna complex", "Protein kinase complex", "Protein lipid complex", "Protein phosphatase type 1 complex", "Protein phosphatase type 2a complex", "Proton transporting atp synthase complex", "Proton transporting atp synthase complex catalytic core f 1", "Proton transporting atp synthase complex coupling factor f o", "Proton transporting two sector atpase complex", "Proton transporting two sector atpase complex catalytic domain", "Proton transporting two sector atpase complex proton transporting domain", "Proton transporting v type atpase complex", "Proton transporting v type atpase v0 domain", "Proton transporting v type atpase v1 domain", "Proximal dendrite", "Prp19 complex", "Pseudopodium", "Ptw pp1 phosphatase complex", "Pwp2p containing subcomplex of 90s preribosome", "R2tp complex", "Ragulator complex", "Rdna heterochromatin", "Receptor complex", "Recycling endosome", "Recycling endosome membrane", "Replication fork", "Replisome", "Respirasome", "Respiratory chain complex iii", "Respiratory chain complex iv", "Retromer complex", "Ribbon synapse", "Ribonuclease mrp complex", "Ribonuclease p complex", "Ribonucleoprotein complex", "Ribonucleoprotein granule", "Ribose phosphate diphosphokinase complex", "Ribosomal subunit", "Ribosome", "Ripoptosome", "Risc loading complex", "Rna cap binding complex", "Rna polymerase complex", "Rna polymerase i complex", "Rna polymerase ii core complex", "Rna polymerase ii holoenzyme", "Rna polymerase ii transcription regulator complex", "Rna polymerase ii transcription repressor complex", "Rna polymerase iii complex", "Rna polymerase iii transcription regulator complex", "Rnai effector complex", "Rough endoplasmic reticulum", "Rough endoplasmic reticulum membrane", "Rpap3 r2tp prefoldin like complex", "Ruffle", "Ruffle membrane", "Saga complex", "Saga type complex", "Sarcolemma", "Sarcoplasm", "Sarcoplasmic reticulum lumen", "Sarcoplasmic reticulum membrane", "Scar complex", "Scf ubiquitin ligase complex", "Schaffer collateral ca1 synapse", "Schmidt lanterman incisure", "Sec61 translocon complex", "Secondary lysosome", "Secretory granule", "Secretory granule membrane", "Secretory vesicle", "Seh1 associated complex", "Septin cytoskeleton", "Serine protease inhibitor complex", "Serine type endopeptidase complex", "Serine type peptidase complex", "Set1c compass complex", "Sex chromatin", "Sex chromosome", "Side of membrane", "Signal peptidase complex", "Signal recognition particle", "Sin3 complex", "Sin3 type complex", "Site of dna damage", "Site of double strand break", "Site of polarized growth", "Sm like protein family complex", "Small ribosomal subunit", "Small subunit processome", "Smc5 smc6 complex", "Smn complex", "Smn sm protein complex", "Smooth endoplasmic reticulum", "Smooth endoplasmic reticulum membrane", "Snare complex", "Sno s rna containing ribonucleoprotein complex", "Sodium potassium exchanging atpase complex", "Somatodendritic compartment", "Sorting endosome", "Spanning component of membrane", "Specific granule", "Specific granule lumen", "Specific granule membrane", "Spectrin", "Spectrin associated cytoskeleton", "Sperm annulus", "Sperm connecting piece", "Sperm fibrous sheath", "Sperm head", "Sperm head plasma membrane", "Sperm midpiece", "Sperm plasma membrane", "Sperm principal piece", "Spermatoproteasome complex", "Spindle", "Spindle microtubule", "Spindle midzone", "Spindle pole", "Spindle pole centrosome", "Spliceosomal complex", "Spliceosomal snrnp complex", "Spliceosomal tri snrnp complex", "Stereocilium bundle", "Stereocilium membrane", "Stereocilium tip", "Striated muscle thin filament", "Sumo ligase complex", "Supramolecular complex", "Supramolecular polymer", "Swi snf complex", "Swr1 complex", "Synapse", "Synaptic membrane", "Synaptic vesicle membrane", "Synaptonemal structure", "T tubule", "Telomerase holoenzyme complex", "Terminal bouton", "Tertiary granule", "Tertiary granule lumen", "Tertiary granule membrane", "Tetraspanin enriched microdomain", "Tho complex", "Tight junction", "Tim22 mitochondrial import inner membrane insertion complex", "Tim23 mitochondrial import inner membrane translocase complex", "Tor complex", "Torc1 complex", "Trans golgi network", "Trans golgi network membrane", "Trans golgi network transport vesicle", "Trans golgi network transport vesicle membrane", "Transcription elongation factor complex", "Transcription export complex", "Transcription export complex 2", "Transcription factor tfiid complex", "Transcription factor tfiih holo complex", "Transcription factor tfiiic complex", "Transcription preinitiation complex", "Transcription regulator complex", "Transcription repressor complex", "Transferase complex", "Transferase complex transferring phosphorus containing groups", "Translation preinitiation complex", "Translocon complex", "Transport vesicle", "Transport vesicle membrane", "Transporter complex", "Trapp complex", "Tricarboxylic acid cycle enzyme complex", "Triglyceride rich plasma lipoprotein particle", "Trna methyltransferase complex", "Trna splicing ligase complex", "Tubular endosome", "U1 snrnp", "U12 type spliceosomal complex", "U2 snrnp", "U2 type catalytic step 2 spliceosome", "U2 type spliceosomal complex", "U2af complex", "U4 snrnp", "U5 snrnp", "U6 snrnp", "U7 snrnp", "Ubiquitin conjugating enzyme complex", "Ubiquitin ligase complex", "Unconventional myosin complex", "Uniplex complex", "Vacuolar lumen", "Vacuolar membrane", "Vacuolar proton transporting v type atpase v0 domain", "Vacuole", "Varicosity", "Vcp npl4 ufd1 aaa atpase complex", "Vesicle coat", "Vesicle lumen", "Vesicle membrane", "Vesicle tethering complex", "Wash complex", "Weibel palade body", "Wnt signalosome", "X chromosome", "Xy body", "Zona pellucida receptor complex", "Zonula adherens", "Zymogen granule", "Zymogen granule membrane"], "available_proteins": ["AAAS", "AARS", "AARS2", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR6", "ADAM17", "ADAR", "ADD1", "ADD3", "ADH5", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8L", "AKR1A1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOL2", "APOO", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARMCX3", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASPH", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "B4GAT1", "BABAM1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCLAF1", "BIRC6", "BLM", "BMS1", "BOLA2*", "BOP1", "BPTF", "BRCA1", "BRD2", "BRI3BP", "BRIX1", "BRMS1L", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BYSL", "C12orf43", "C12orf73", "C19orf70", "C1QBP", "C1orf35", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CAST", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC47", "CCDC86", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD3EAP", "CDC23", "CDC27", "CDC34", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKAL1", "CEBPZ", "CECR2", "CELF1", "CENPB", "CENPI", "CEP170", "CERS2", "CFAP20", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD4", "CHERP", "CHID1", "CHMP3", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLTC", "CMPK1", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT10", "CNOT3", "CNOT6", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG7", "COIL", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "CORO1B", "CORO1C", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CWC15", "CWF19L1", "CXorf57", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF13", "DCAF7", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DERL1", "DFFA", "DGCR8", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNTTIP2", "DOCK7", "DPF2", "DPM1", "DPP9", "DPYSL2", "DRG1", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI2", "ECSIT", "EDC3", "EDC4", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5A", "EIF6", "ELAC2", "ELAVL1", "ELOA", "ELOB", "ELP1", "ELP2", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "ENY2", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERH", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAHD1", "FAM162A", "FAM208A", "FAM49B", "FAM8A1", "FAM98A", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP4", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNTB", "FOXC1", "FOXK1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUCA2", "FUNDC2", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GGCX", "GGH", "GIGYF2", "GINS1", "GINS4", "GLA", "GLB1", "GLDC", "GLE1", "GLG1", "GLMN", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GNA13", "GNAI2", "GNAI3", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNS", "GOLGA3", "GOLGB1", "GOLIM4", "GORASP2", "GOT2", "GPAA1", "GPATCH4", "GPD2", "GPI", "GPR107", "GPR108", "GPS1", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSR", "GSTK1", "GSTM3", "GSTZ1", "GTF2E1", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAUS5", "HAX1", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HELLS", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIF1AN", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HOXA10", "HP1BP3", "HPF1", "HPS6", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILK", "ILVBL", "IMMT", "IMP3", "IMPDH2", "INA", "INCENP", "INF2", "INTS11", "INTS14", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "ISOC1", "IST1", "ITCH", "ITGB1", "IVD", "JUP", "KARS", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KIAA0368", "KIAA0391", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC2", "KLC4", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMP1", "LAMTOR1", "LAMTOR2", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDAH", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3BP", "LGMN", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC59", "LRWD1", "LSM2", "LSM6", "LSS", "LTA4H", "LTV1", "LUC7L", "LUC7L3", "LYAR", "LYPLA1", "MACF1", "MAGED2", "MAGT1", "MAK16", "MAP1B", "MAP1S", "MAP2K1", "MAP4", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARK2", "MARS", "MAT2A", "MATR3", "MAU2", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED16", "METTL13", "MFN1", "MFN2", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MINPP1", "MKI67", "MLEC", "MMAB", "MMGT1", "MMS19", "MOB4", "MOGS", "MORF4L1", "MOV10", "MPHOSPH10", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MTA1", "MTA2", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTPN", "MTX1", "MTX2", "MTX3", "MYBBP1A", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAGLU", "NAMPT", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFAF7", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFCD", "NENF", "NES", "NEU1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NISCH", "NKRF", "NLE1", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPLOC4", "NPM1", "NPTN", "NRBP1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "OAT", "OCIAD1", "OCLN", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL11", "OSBPL6", "OSBPL9", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAK2", "PAK4", "PALLD", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCM1", "PCNA", "PCNP", "PCYOX1", "PDCD11", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PECR", "PEF1", "PELP1", "PES1", "PEX14", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGK1", "PGM1", "PGM2", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHF6", "PHIP", "PI4KB", "PICALM", "PIGS", "PIGT", "PIN4", "PISD", "PITPNB", "PITRM1", "PKM", "PKN2", "PLAA", "PLBD2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA2", "PPAN", "PPIB", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPP1CA", "PPP1R10", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PPT1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2C", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTK7", "PTPA", "PTPN1", "PTRH2", "PUM3", "PURA", "PUS1", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RABGGTA", "RABL6", "RAC1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAD51AP1", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RARS2", "RBBP6", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM27", "RBM28", "RBM34", "RBM39", "RBM4", "RBM45", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "RECQL5", "REEP5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIF1", "RINT1", "RIOK2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF20", "RNF40", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA3", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF8", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCP2", "SCRIB", "SCRN1", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFXN1", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SIRT2", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35A4", "SLC35B2", "SLC3A2", "SLC6A15", "SLC9A3R1", "SLFN11", "SLIRP", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX2", "SNX3", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPCS2", "SPCS3", "SPEN", "SPTAN1", "SPTBN1", "SPTLC1", "SQLE", "SQSTM1", "SRCAP", "SRI", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "SSU72", "STAG2", "STARD3", "STAT3", "STAU1", "STAU2", "STEAP3", "STIP1", "STMN1", "STOML2", "STRAP", "STRBP", "STRN4", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TACO1", "TAF15", "TAMM41", "TAP1", "TAP2", "TARDBP", "TARS2", "TBCA", "TBCE", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TEX10", "TFAM", "TFG", "TFRC", "THG1L", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMMDC1", "TJP1", "TJP2", "TKT", "TLN1", "TMCO1", "TMED10", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM126B", "TMEM192", "TMEM201", "TMEM214", "TMEM230", "TMEM33", "TMEM43", "TMEM65", "TMEM97", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX4", "TNKS1BP1", "TNPO1", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOX4", "TP53", "TP53BP1", "TPD52", "TPM3", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC5", "TRIM25", "TRIM28", "TRIP12", "TRIP13", "TRMT10C", "TRMT6", "TRMU", "TRNT1", "TROVE2", "TSC2", "TSFM", "TSG101", "TSN", "TSPAN6", "TSR1", "TTC1", "TTC19", "TTC21B", "TTC26", "TTC37", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNG", "TXNDC12", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF2", "UBA1", "UBA2", "UBAP2L", "UBE2K", "UBE2L3", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBQLN4", "UBR4", "UBR5", "UBTF", "UCHL5", "UFD1", "UFL1", "UGGT1", "UHRF1", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF3B", "UQCR10", "UQCRC1", "UQCRC2", "UQCRQ", "USMG5", "USO1", "USP10", "USP14", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VPS13A", "VPS16", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WBP11", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR43", "WDR45B", "WDR46", "WDR5", "WDR61", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIZ", "WRAP53", "XAB2", "XPO1", "XPO4", "XPO5", "XPO7", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", 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sha256:604d67f1f310030924bb760a675af973d8326f16dd9b4a9afe8152bc63b9bcde +size 208355 diff --git a/msigdb_gomf/df_merge.tsv b/msigdb_gomf/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..9e11be181aa5fe3c1c02a9966519637f0c0bcd52 --- /dev/null +++ b/msigdb_gomf/df_merge.tsv @@ -0,0 +1,34 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 +Peptidase activity 16 97 3.448108197193405 0.0005645278460881 29.021844660194176 113.626213592233 1.2572335980018865 0.3731282983707893 8.334453494010912 9.805689463637474 1.5136028692995414 0.3922229485757941 1.0227198624600388e-05 5.088610222189162e-06 0.0002877156020689 0.0487699312734532 +Hydrolase activity acting on glycosyl bonds 11 24 3.3413315857422083 0.0008337758232981 10.133495145631068 28.40776699029126 0.6089784953463463 0.2409908190925149 3.36301188653944 3.2424277527979313 1.935823411407979 0.3010513017078077 5.894154127020414e-11 4.52279643065252e-12 1.6948833479992797e-07 0.0001947393019236 +Exopeptidase activity 9 29 3.1292848404113265 0.0017523235192913 9.74514563106796 31.84223300970874 1.193034763402526 0.2308543476384821 3.0338864063053523 1.9513159274241312 1.6646797512653713 0.2911825093455628 1.5730610356725724e-08 1.2377249757325933e-07 1.900552132048628e-06 3.14595400221692e-05 +Hydrolase activity hydrolyzing o glycosyl compounds 10 18 3.0041637038303657 0.0026631199010358 8.830097087378642 20.84223300970874 0.5983257656540719 0.2104301479001341 3.2223833352824554 2.4557961681485057 1.9540573665272416 0.2728112677124137 6.05434514102961e-11 7.702502150948301e-13 1.5031792152809894e-08 1.4724035658487924e-05 +Exogenous protein binding 8 14 2.773786360117398 0.0055408051826111 4.509708737864078 15.157766990291265 0.7214109752050332 0.2527966464979699 2.499010078306418 1.9009100692398744 1.5211756979359785 0.2791170769282048 2.4350782386469327e-06 4.574487949716839e-06 1.0995319586725862e-06 0.0002699095083601 +Serine hydrolase activity 6 17 2.757637351912327 0.0058220748211363 6.934466019417476 18.83009708737864 1.2767207242593377 0.1489147276149277 2.386872767465543 1.965791668457755 1.709796217367629 0.2208345231085202 3.375280228925014e-06 0.0001005941709316 0.0001490938709755 0.0020547334314456 +Molecular transducer activity 9 23 2.6868590800901035 0.0072127375484314 10.91747572815534 33.40533980582524 1.343848990749489 0.2329582295822712 4.7124072380860955 5.830391636254363 1.6098335072319665 0.2956883791113679 0.0083573494163467 0.0410940094333546 0.1007846762112188 0.8162996269730327 +Transporter activity 35 131 2.665936315398481 0.0076774234999603 62.22330097087379 172.27912621359224 2.173366592838491 0.2707201784543502 25.984753572620328 19.29276868436311 2.593156143256053 0.3916539604106395 0.0126888664997837 0.000511935758462 0.0003884490192338 0.0008297283167159 +Cholesterol binding 3 10 2.5780636345788475 0.0099355699322138 5.25 13.29126213592233 1.1679703080780182 0.1357521674166823 1.9454015982929531 1.7674569958716484 1.7544522374432017 0.2116991383290636 0.0004104233816526 0.0001962671730819 0.0057743966142769 0.0564014374232863 +Glycosaminoglycan binding 4 14 2.565324291036684 0.01030794146055 4.978155339805825 17.45631067961165 0.1337124269810174 0.5629551361084434 2.38360266105164 2.069316753377374 0.9690169198659552 0.3148101721496325 0.0002779956342849 0.0037316022130222 0.0209967954960545 0.0967117126938573 +Steroid binding 4 18 2.472325973930455 0.013423705243047 8.424757281553399 21.398058252427184 1.4469817519716153 0.1523451695819165 3.035656818503787 2.066091501771892 1.85140774519605 0.2395996334984524 0.0017444833819082 0.0001111606586644 0.0066284009542843 0.0310662112019685 +Carboxypeptidase activity 4 12 2.462225277892001 0.0138077908190541 3.941747572815534 11.944174757281552 0.6619369631013473 0.2217581052142344 1.5253536449314826 0.7722681563953175 1.6063564059694095 0.2594343390807456 5.058405266226161e-06 7.961405550860943e-05 0.0002424536403162 0.005348590970678 +Sterol binding 3 13 2.42613442632866 0.0152606165018585 5.495145631067961 16.27912621359223 1.1610523788441311 0.1592175050218891 2.159304933149918 1.9111962434971217 1.7231989277496158 0.231586711794193 0.0007069993740851 0.0004032716772888 0.0110758722051871 0.0968264519151924 +Heparin binding 2 10 2.4090652790850093 0.0159934370069507 3.4344660194174756 11.91504854368932 0.417671776261347 0.5410412518682232 1.977562601051691 1.5719219414069263 0.9122022863658426 0.3149614964035694 0.0012757726476668 0.009062215893767 0.0918272438847456 0.1661443482772651 +Phosphatidylserine binding 2 9 2.300848858110999 0.0214001756931521 2.029126213592233 10.060679611650484 0.6615116985008255 0.3340719518205703 1.5854698894895154 0.9597266622759548 1.1646704221215245 0.2873190862432436 0.0003334624710947 0.002509898486982 0.0300655360870906 0.0454470617698533 +Anion transmembrane transporter activity 7 30 2.2731187723494584 0.0230190234628131 18.594660194174757 45.61893203883495 1.6222323024349488 0.2373683627198559 9.346785472607134 6.017202751823004 1.8117646078257517 0.3183345645365742 0.4637995473310806 0.1264484795755822 0.0880900807686078 0.1627259626648422 +Modified amino acid binding 2 19 2.246673309181113 0.0246609132426685 4.446601941747573 21.354368932038835 0.8157790161756342 0.4133026066112408 2.099367243274066 1.7995833767593454 0.9656025978141096 0.3166170247143811 0.0016433207319013 0.0115064399741943 0.1119144158382109 0.2059272882058018 +Hexosyltransferase activity 6 25 2.2339497032972018 0.0254863826577111 9.633495145631068 33.87864077669903 0.7349501031127185 0.3949358882560483 4.261380470236419 4.330948695045228 1.2646745007039175 0.3422146027467064 0.0182301376254106 0.025600369736322 0.0215079909801002 0.1049475666708193 +Serine type exopeptidase activity 5 7 2.230233169942226 0.0257319672520015 3.783980582524272 6.997572815533981 1.020609253431403 0.1137432544246352 1.3363606860118669 0.0492066381861973 1.87035730934538 0.1990592265121372 2.867520455866967e-10 1.0023212047123017e-08 1.578631333778629e-08 9.76257263135182e-07 +Metallopeptidase activity 3 37 2.2253793894714504 0.0260557799598752 11.548543689320388 40.60436893203884 1.2053444242445344 0.3510417366391842 4.586289489033314 2.1135899474190585 1.0988837346562612 0.3462572593421246 0.0006152777977496 0.0077976080130679 0.0133275956191841 0.0409193590402321 +Carbohydrate binding 9 38 2.169247938214403 0.030063865437129 11.281553398058252 45.27669902912621 0.1331338248817691 0.6071141686502306 4.369282618080822 4.120884622804317 0.96731611422719 0.3295982480677992 0.0190851931940472 0.0270700304702826 0.0005310967041711 0.0015160928663664 +Gated channel activity 1 9 2.169204332137268 0.0300671743978528 4.317961165048544 13.019417475728156 0.8697524591818097 0.2583579989367679 2.2914716766946497 2.0107989163575497 1.3733766112751231 0.2762671399351702 0.2560754722464486 0.1170412325774002 0.4328786381018912 0.7986145146397201 +Glycosyltransferase activity 6 36 2.1508886877244437 0.0314849866315836 10.808252427184469 46.75 0.6230735361107147 0.5000303532444054 4.489970468729936 5.6981622825309435 0.9932734853426128 0.358363386747457 0.0427934356613144 0.0708670341065168 0.0946318432858537 0.3736493403730689 +Metalloexopeptidase activity 2 18 2.150424714107241 0.0315216351956675 5.395631067961165 20.067961165048544 0.9825976981990544 0.3457114951896768 2.1791777953827336 1.4039620491256346 0.996651753778752 0.2995335114577974 0.0006503204391585 0.0047719907059414 0.0100334254948701 0.0063839064386904 +Udp glycosyltransferase activity 4 11 2.125633654824447 0.033533775074741 5.111650485436893 16.645631067961165 0.3599735227181602 0.3819150449260511 2.50187506268716 3.5246228662547776 1.2344018614792536 0.2994506580113357 0.0058478787222266 0.0372017462297913 0.0361429003688962 0.159167010091121 +Lipid transporter activity 3 14 2.1097930820665747 0.0348761826086667 6.546116504854369 19.805825242718445 0.7389006587243017 0.301332987440896 3.074370954053146 3.741159812966952 1.4134673193588587 0.2984913911167897 0.0062917946367029 0.0068221584627764 0.0398082827338284 0.081355924012233 +Inorganic anion transmembrane transporter activity 3 11 2.098667535883981 0.0358462183620158 7.427184466019417 19.274271844660195 1.0921593405593897 0.2441056926448881 3.717191605498929 3.7816647851785734 1.4014196343960104 0.2816216967014333 0.2260688267312995 0.0921147949975289 0.1335053000482259 0.1086169414893013 +Serine type carboxypeptidase activity 4 5 2.0868531596313997 0.0369014100891906 3.0558252427184467 4.997572815533981 1.0019911760482532 0.1105835516254352 1.1231414198895626 0.0492066381861973 1.8086551291944464 0.1930654928989846 2.549415016831829e-09 4.323688101754453e-08 8.350760865063851e-09 2.7269453249964204e-07 +Growth factor binding 5 11 1.9799442723787803 0.0477097909341999 4.310679611650485 12.949029126213592 -0.0488380105863232 0.5194853451197696 2.1509949209095054 2.534197950354086 1.057563900891323 0.317878019437427 0.0448936661684744 0.0046250534965286 0.0066294247629262 0.0505496054928521 +Anion channel activity 1 6 1.9750315916390928 0.0482645630131188 4.20873786407767 11.21116504854369 1.03959259790327 0.2192420598609839 2.3076742714116403 2.0905640066649145 1.3937691950814175 0.2662450395835827 0.1287528218161406 0.0305060181117638 0.1486468007453543 0.4002722624509632 +Protein tyrosine kinase activity 1 9 1.9739291329233264 0.0483898015988883 5.012135922330097 13.58980582524272 -0.3853098962361698 0.5582723721465958 3.318431653917148 2.9459850844218423 0.8131778391228522 0.3077327579735024 0.3587798531269947 0.2207687903192562 0.649818170513556 0.9387577705701072 +Alcohol binding 3 13 1.9684100220245464 0.0490208796916897 5.70873786407767 16.094660194174757 1.0972550148478282 0.1642412137618775 2.3364194162363723 2.1334758164294443 1.72577974721897 0.2306417307890987 0.0018494623097264 0.0014196759684318 0.0332787643737564 0.2267695434684957 +5 3 exonuclease activity 1 7 1.964820097666962 0.0494350632285487 1.575242718446602 8.390776699029127 0.5765406383086242 0.4470853546610586 1.3800480817993432 1.012165024842944 0.9112283530858464 0.2958732165203356 0.0847528009868792 0.0131546828557762 0.0703212183088513 0.2186430557746356 diff --git a/msigdb_gomf/metrics.json b/msigdb_gomf/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..418cd5b68218bd48185f7459887466c92a88fcf4 --- /dev/null +++ b/msigdb_gomf/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2453, + "annotations_size": 1304, + "title": "Average number of proteins per term", + "value": 14.04064417177914 +} \ No newline at end of file diff --git a/msigdb_gomf/paths.json b/msigdb_gomf/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..d7912e5cc4a4c3281054888103fd6c38ffaabffb --- /dev/null +++ b/msigdb_gomf/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gomf/fragment/C334/C334_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gomf/result.tsv b/msigdb_gomf/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..b54f89bc6acb8cf4c7f77106c2bae9977e81d430 --- /dev/null +++ b/msigdb_gomf/result.tsv @@ -0,0 +1,358 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Peptidase activity 0.6093911174131514 3.448108197193405 0.0005645278460881 0.5211424788833448 0.0063460716491292 97 Q9HB40,P55786,P49721,Q9UIQ6,P10619,Q99538,P02786,O14773,P42785,Q92820,P42892,O75976,Q92542,O43464,P28072,Q9H3G5 16 +Hydrolase activity acting on glycosyl bonds 0.8728678472628776 3.3413315857422083 0.0008337758232981 0.6630083695597573 0.0084282455316338 24 P06865,Q99519,O75503,P06280,P07686,Q9BTY2,P10253,P17900,P04062,P54802,P16278 11 +Exopeptidase activity 0.8032991413110924 3.1292848404113265 0.0017523235192913 0.8984327630551507 0.0136013682687851 29 Q9HB40,Q9UIQ6,P10619,P02786,O14773,P42785,Q92820,O75976,Q9H3G5 9 +Hydrolase activity hydrolyzing o glycosyl compounds 0.8893581069520538 3.0041637038303657 0.0026631199010358 0.9691105536802028 0.019133910234249 18 P06865,Q99519,P06280,P07686,Q9BTY2,P10253,P17900,P04062,P54802,P16278 10 +Exogenous protein binding 0.9041970127181213 2.773786360117398 0.0055408051826111 0.9992864806106152 0.0357654724139709 14 P11279,Q8WTV0,Q92692,P02786,O15118,Q9Y624,Q14108,P35613 8 +Serine hydrolase activity 0.8500547067580335 2.757637351912327 0.0058220748211363 0.99950659108119 0.0372156155233424 17 Q9HB40,P10619,O14773,P42785,O75976,Q9H3G5 6 +Molecular transducer activity 0.7568759273013329 2.6868590800901035 0.0072127375484314 0.99992047929482 0.0445754017211118 23 Q9ULM6,Q8WTV0,Q92692,Q99523,O15118,Q15375,P11717,Q14108,P05556 9 +Galactosidase activity 0.988168094655243 2.673640075632873 0.0075032933293452 0.9999457108612204 0.0457761709034918 2 P06280 1 +Galactoside binding 0.988168094655243 2.673640075632873 0.0075032933293452 0.9999457108612204 0.0457761709034918 2 P06280 1 +Transporter activity 0.5005421457654284 2.665936315398481 0.0076774234999603 0.999956813767648 0.0465556803624371 131 Q9BSK2,Q9C0H2,P61916,Q13423,P17900,O15439,Q8IXU6,O60830,Q93050,Q8TB61,P61421,Q8WTV0,P05026,Q9Y487,O15118,O96008,P51790,Q9H2J7,Q9NS69,P55011,O43772,Q9HD20,Q99595,Q14849,O14925,Q9UM00,P04062,Q03519,P20020,Q9H2D1,P08195,Q93034,Q8N4V1,P08183,O43808 35 +Lysophosphatidic acid binding 0.9816401468788254 2.6469831646023567 0.00812133960402 0.999975903995405 0.0470946581831726 2 P50897 1 +Sulfatide binding 0.9816401468788254 2.6469831646023567 0.00812133960402 0.999975903995405 0.0470946581831726 2 P50897 1 +Transmembrane receptor protein tyrosine kinase activity 0.9796001631986948 2.6386371144230787 0.0083240031049927 0.9999815404511744 0.0475799610863553 2 P11717 1 +Transmembrane receptor protein kinase activity 0.9796001631986948 2.6386371144230787 0.0083240031049927 0.9999815404511744 0.0475799610863553 2 P11717 1 +Volume sensitive anion channel activity 0.978784169726643 2.6352965913628656 0.0084063793414228 0.999983435580053 0.0475799610863553 2 Q9C0H2 1 +5 3 exodeoxyribonuclease activity 0.9702162382700948 2.6001485165548206 0.0093183422347271 0.999995010059588 0.0517068862726988 2 Q8IV08 1 +Cholesterol binding 0.9190934689001412 2.5780636345788475 0.0099355699322138 0.9999977861450736 0.0539832632983621 10 Q14108,P61916,O15118 3 +Glycosaminoglycan binding 0.8548356934853902 2.565324291036684 0.01030794146055 0.999998644462945 0.0553150438870668 14 P05067,P15586,Q06481,O94813 4 +Steroid binding 0.7744315790657437 2.472325973930455 0.013423705243047 0.9999999777975114 0.0689154001454068 18 Q14108,P61916,Q14849,O15118 4 +Carboxypeptidase activity 0.8611497862865765 2.462225277892001 0.0138077908190541 0.9999999866376208 0.0706092518746925 12 Q9HB40,P10619,Q9H3G5,O75976 4 +Sterol binding 0.8377662863196728 2.42613442632866 0.0152606165018585 0.9999999980457288 0.0768333742024073 13 Q14108,P61916,O15118 3 +Acetylgalactosaminyltransferase activity 0.9273765809873532 2.422420260872322 0.0154175089334804 0.9999999984123698 0.0769547479677766 2 Q10472 1 +Polypeptide n acetylgalactosaminyltransferase activity 0.9273765809873532 2.422420260872322 0.0154175089334804 0.9999999984123698 0.0769547479677766 2 Q10472 1 +Heparin binding 0.8761934869352462 2.4090652790850093 0.0159934370069507 0.999999999259738 0.0789978858222113 10 P05067,Q06481 2 +Solute sodium symporter activity 0.9220726234190147 2.400185943903997 0.0163867454544868 0.999999999560477 0.0806351549911351 2 Q9H2J7 1 +Transition metal ion transmembrane transporter activity 0.9204406364749096 2.3933344765912272 0.0166960128588788 0.9999999997083302 0.0818481231878875 2 Q8N4V1 1 +Oxidoreductase activity acting on a sulfur group of donors disulfide as acceptor 0.9143206854345178 2.367599066676397 0.0179039260758739 0.9999999999412804 0.0871146253841032 2 Q8IXB1 1 +Unmethylated cpg binding 0.9135046919624656 2.3641626270270586 0.0180708780260427 0.999999999952956 0.08760009273591 2 Q9Y2K7 1 +Phosphatidylserine binding 0.8623336660910064 2.300848858110999 0.0214001756931521 0.9999999999994388 0.1014757421958922 9 Q14108,Q06481 2 +Anion transmembrane transporter activity 0.6478737013282011 2.2731187723494584 0.0230190234628131 0.9999999999999352 0.1068213757847272 30 P55011,Q9C0H2,P08195,P51790,O15439,O43808,Q9H2D1 7 +Efflux transmembrane transporter activity 0.887392900856794 2.253573420038475 0.0242230170468569 0.999999999999987 0.1112211768630331 2 P08183 1 +Abc type xenobiotic transporter activity 0.887392900856794 2.253573420038475 0.0242230170468569 0.999999999999987 0.1112211768630331 2 P08183 1 +Modified amino acid binding 0.715144902139455 2.246673309181113 0.0246609132426685 0.9999999999999928 0.1128344942752271 19 Q14108,Q06481 2 +Protein prenyltransferase activity 0.8833129334965333 2.2361855870368887 0.0253396169296966 0.9999999999999972 0.1145804130351647 2 Q92696 1 +Hexosyltransferase activity 0.6597594166830262 2.2339497032972018 0.0254863826577111 0.9999999999999976 0.1145804130351647 25 Q13126,Q10472,P06865,P07686,P04062,O43505 6 +Serine type exopeptidase activity 0.948976485656134 2.230233169942226 0.0257319672520015 0.9999999999999982 0.1145804130351647 7 Q9HB40,P10619,O14773,O75976,Q9H3G5 5 +Metallopeptidase activity 0.6036030571797126 2.2253793894714504 0.0260557799598752 0.9999999999999988 0.1155671328832563 37 P42892,Q9UIQ6,P02786 3 +Scavenger receptor activity 0.9861224489795916 2.1950993653047934 0.0281564707435268 1.0 0.1232081807032183 3 Q14108,Q08380 2 +Carbohydrate binding 0.5892014116327435 2.169247938214403 0.030063865437129 1.0 0.1293980046693075 38 Q10472,O75503,P10253,Q10471,P17858,P08236,P11717,P35613,Q12907 9 +Gated channel activity 0.8293428924606925 2.1692043321372676 0.0300671743978528 1.0 0.1293980046693075 9 Q9C0H2 1 +Glycosyltransferase activity 0.5983628182856784 2.1508886877244433 0.0314849866315836 1.0 0.1334552347245144 36 Q13126,Q10472,P06865,P07686,P04062,O43505 6 +Metalloexopeptidase activity 0.7084842635883569 2.150424714107241 0.0315216351956675 1.0 0.1334552347245144 18 Q9UIQ6,P02786 2 +Acetylglucosaminyltransferase activity 0.972030465904348 2.1300109500758873 0.033170709349771 1.0 0.1386365544618636 4 P06865,O43505 2 +Udp glycosyltransferase activity 0.7937780980262656 2.125633654824447 0.033533775074741 1.0 0.1397062067011577 11 P06865,Q10472,P07686,O43505 4 +Lipid transporter activity 0.7513634350026065 2.1097930820665747 0.0348761826086667 1.0 0.1434654325605724 14 P17900,P61916,O15118 3 +Inorganic anion transmembrane transporter activity 0.7873733416104165 2.0986675358839815 0.0358462183620158 1.0 0.1460733398252146 11 P55011,Q9C0H2,P51790 3 +Serine type carboxypeptidase activity 0.9558823529411766 2.0868531596313993 0.0369014100891906 1.0 0.1485167862848908 5 Q9HB40,P10619,Q9H3G5,O75976 4 +Retromer complex binding 0.9506902444557412 2.0514362715427317 0.0402244798178914 1.0 0.1561092907218168 4 P11717 1 +Lipase binding 0.8372093023255814 2.0377296192406487 0.0415769803385903 1.0 0.1585274338056194 2 Q96CS3 1 +Bubble dna binding 0.8298653610771163 2.005793078930486 0.044878329396949 1.0 0.1689989773687013 2 P54132 1 +Rage receptor binding 0.8298653610771112 2.005793078930465 0.0448783293969512 1.0 0.1689989773687013 2 P26583 1 +Acetylcholine receptor binding 0.8290493676050629 2.0022392877115256 0.0452590021402694 1.0 0.1695912034221591 2 Q15334 1 +Sterol transfer activity 0.9343894797045342 2.0006187578957135 0.0454334905520217 1.0 0.1697326092296755 3 P61916 1 +Vitamin d binding 0.8253773969808298 1.9862342799960384 0.0470073161516304 1.0 0.1741407393799037 2 P04062 1 +Growth factor binding 0.759411827760112 1.9799442723787803 0.0477097909341999 1.0 0.1762424005048065 11 Q99523,O43847,Q15375,Q92896,P11717 5 +Anion channel activity 0.9311680767594372 1.9750315916390928 0.0482645630131188 1.0 0.177312833804866 6 Q9C0H2 1 +Protein tyrosine kinase activity 0.7813351530812931 1.9739291329233264 0.0483898015988883 1.0 0.177312833804866 9 P11717 1 +Alcohol binding 0.7329720109803058 1.9684100220245464 0.0490208796916897 1.0 0.1786042275469074 13 Q14108,P61916,O15118 3 +5 3 exonuclease activity 0.877266695682854 1.964820097666962 0.0494350632285487 1.0 0.1790647845834098 7 Q8IV08 1 +Cargo receptor activity 0.9149506788293104 1.9371560571854725 0.0527262699507269 1.0 0.1850968968825891 5 Q14108,Q08380,P02786 3 +G protein alpha subunit binding 0.9175510204081624 1.9365777515921 0.0527969797679159 1.0 0.1850968968825891 3 Q02818,P11717 2 +Hexosaminidase activity 0.9137121212250224 1.9325929036479532 0.0532863673125776 1.0 0.1850968968825891 5 P06865,P07686,P17900 3 +Peptide binding 0.505938282146224 1.9323081094148873 0.0533214880970969 1.0 0.1850968968825891 61 Q8TEX9,Q8WTV0,Q9UIQ6,P10321,O14773,P01889,Q15392,P42892,Q03519,P55786 10 +Endopeptidase activity 0.5218829114133391 1.9321086078877343 0.0533461021115138 1.0 0.1850968968825891 54 P60900,P49721,Q99538,O14773,P42892,Q92542,O43464,P28072 8 +Exodeoxyribonuclease activity 0.7707285325610538 1.9302027532147537 0.0535817205624429 1.0 0.1850968968825891 9 Q8IV08 1 +Antiporter activity 0.7703882212325709 1.928796371282954 0.0537561465080556 1.0 0.1850968968825891 9 P51790 1 +Extracellular matrix binding 0.9151253805271335 1.9273238768958496 0.0539392797663986 1.0 0.1850968968825891 3 O94813 1 +Laminin binding 0.9151253805271335 1.9273238768958496 0.0539392797663986 1.0 0.1850968968825891 3 O94813 1 +Sulfur compound binding 0.5593614352236106 1.9229184653642584 0.054490290358081 1.0 0.1863201482270122 37 P05067,O94813,Q06481,P15586 4 +Hsp70 protein binding 0.6972391992435244 1.9207716606060852 0.0547605007265856 1.0 0.1863201482270122 15 O60884,Q8IXB1,P02786 3 +Ion transmembrane transporter activity 0.4803355859146368 1.9196177395388896 0.0549062016423951 1.0 0.1863201482270122 77 Q9C0H2,Q13423,O15439,Q93050,Q8TB61,P61421,P05026,Q9Y487,P51790,Q9H2J7,P55011,O43772,Q9HD20,Q9UM00,Q9H2D1,P08195,Q93034,Q8N4V1,O43808 19 +Organic acid transmembrane transporter activity 0.6826256156841003 1.9143010476506963 0.0555817006597452 1.0 0.1863201482270122 16 Q9H2J7,P08195,Q9H2D1,P08183 4 +Signaling receptor binding 0.4392093355977916 1.9099370985625352 0.0561413127013208 1.0 0.1870488595171086 139 P05067,P06280,Q9UMX5,O94813,Q15375,Q92542,Q92896,O00170,P05556,Q13501,P01889,Q9Y624,P04062,Q03519,P08236,Q15334,Q9BQE5,Q07021,P11233,P67870 20 +Signaling receptor regulator activity 0.7198305522121332 1.9092533911195892 0.0562294117566768 1.0 0.1870488595171086 13 P05067,Q15375 2 +Amino acid transmembrane transporter activity 0.8127596891642082 1.9066175542555783 0.0565701302261918 1.0 0.1877034346436492 8 Q9H2J7 1 +Beta n acetylhexosaminidase activity 0.902689484505708 1.8725802138716008 0.0611263756915041 1.0 0.2002733515118628 4 P06865,P17900 2 +Glucosidase activity 0.8906053285629114 1.8471159797980168 0.0647303329932653 1.0 0.2094500104794492 5 P10253 1 +Lipid binding 0.4434369668792869 1.8445184664278105 0.0651076171306987 1.0 0.2101493384614634 100 Q8WTV0,P61916,O14773,O15118,Q14849,P04062,P50897,P11717,Q14108,A6NIH7,Q06481 11 +Growth factor receptor binding 0.667216844581835 1.8388677284214492 0.0659346434613066 1.0 0.2117703819545414 16 P05067 1 +Protein lipid complex binding 0.8898044007348369 1.8303120510916948 0.0672032903730597 1.0 0.2137031469333469 3 Q8WTV0 1 +High density lipoprotein particle binding 0.8898044007348369 1.8303120510916948 0.0672032903730597 1.0 0.2137031469333469 3 Q8WTV0 1 +Molecular function activator activity 0.7244062244062361 1.82906875402175 0.0673893091037438 1.0 0.2137031469333469 11 O95433,Q5JTV8,P05026,Q99615,Q96KC8,Q8IXB1,Q99543,O60884,P54709,P25685 10 +Atpase activator activity 0.7244062244062361 1.82906875402175 0.0673893091037438 1.0 0.2137031469333469 11 O95433,Q5JTV8,P05026,Q99615,Q96KC8,Q8IXB1,Q99543,O60884,P54709,P25685 10 +Metal ion transmembrane transporter activity 0.6340372733034114 1.8275798765136329 0.0676126282120679 1.0 0.2137031469333469 19 P55011,Q9HD20,P05026,P08195,Q93034,Q9UM00,Q8N4V1,Q9H2J7,P20020 9 +Single stranded dna exodeoxyribonuclease activity 0.8896037601570789 1.8233408280054724 0.0682517862595035 1.0 0.213949940613928 4 Q8IV08 1 +Adrenergic receptor binding 0.8879883806496867 1.8233264090066557 0.0682539687848113 1.0 0.213949940613928 3 Q07021 1 +Sterol transporter activity 0.8355342062642033 1.8069379791161684 0.070771950003905 1.0 0.2197300542978384 7 P61916,O15118 2 +Solute cation antiporter activity 0.8803473256222286 1.7938945015263046 0.0728300092493168 1.0 0.2238265936593537 3 P51790 1 +Chaperone binding 0.5544733843006076 1.789821525426093 0.0734826075922643 1.0 0.2244059023426526 34 P55011,Q15185,Q8IXB1,P02786,P01889,O60884,Q13217,O43808,Q14108 9 +Serine type endopeptidase inhibitor activity 0.8780657027752258 1.782744019219294 0.0746279822133284 1.0 0.2266347780378136 6 P05067 1 +Histone deacetylase activity h3 k14 specific 0.7768257853937219 1.7727359328011207 0.0762724739474052 1.0 0.2307640511076946 2 Q13547 1 +Modified amino acid transmembrane transporter activity 0.8722360520727874 1.7625837677502434 0.0779707167763035 1.0 0.2348125050260965 3 Q9H2D1 1 +Xenobiotic transmembrane transporter activity 0.8619289263377082 1.7227003666380782 0.0849427240055735 1.0 0.2500553003869738 3 P08183 1 +Exonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters 0.5816987807421056 1.7184376975953564 0.0857168092584181 1.0 0.2500553003869738 23 Q9UQ84,Q8IV08,Q9Y2L1 3 +Lipid transfer activity 0.8541986123548906 1.7111782338536052 0.0870482154760416 1.0 0.2522463844016852 5 P61916 1 +Single stranded dna 3 5 exodeoxyribonuclease activity 0.7617299061607521 1.7057114167653258 0.0880618229646132 1.0 0.2536009891840481 2 Q07864 1 +Monosaccharide binding 0.5675820035831806 1.7049946672529808 0.0881954190037723 1.0 0.2536009891840481 26 O75503,P17858,P11717,P35613,Q12907 5 +Phosphoprotein binding 0.6307845425844523 1.7044685009051057 0.088293595927575 1.0 0.2536009891840481 17 P42345,Q8IWS0,P11717,Q9UPN6,P62993,Q9Y2W1 6 +Inorganic molecular entity transmembrane transporter activity 0.4843580368815784 1.690591034219411 0.0909149382224769 1.0 0.2582855761266012 58 P55011,P61421,Q9HD20,P05026,Q9C0H2,P08195,Q9Y487,Q93034,Q13423,Q9UM00,Q8N4V1,O15439,P51790,Q93050,Q9H2J7 15 +Coreceptor activity 0.8524786975459986 1.686042726355926 0.0917875701446513 1.0 0.2594354315118802 3 Q92692 1 +Vascular endothelial growth factor receptor binding 0.7486740106079176 1.6475359393274964 0.0994479354066817 1.0 0.2753293158605371 2 Q9Y5K6 1 +Deoxyribonuclease activity 0.6379410511673381 1.6352998184755283 0.1019862116166265 1.0 0.2805696623377237 15 Q9UQ84,Q8IV08 2 +Cyclic nucleotide dependent protein kinase activity 0.7417380660954789 1.61655971063348 0.105973354599258 1.0 0.2890988585720345 2 Q12802 1 +Camp dependent protein kinase activity 0.7417380660954789 1.61655971063348 0.105973354599258 1.0 0.2890988585720345 2 Q12802 1 +Secondary active transmembrane transporter activity 0.6312284296561244 1.6024891969712838 0.1090474745406067 1.0 0.2937973281011387 15 Q9H2J7,P08195,P51790 3 +Chemokine binding 0.8302040816326519 1.599329143739698 0.1097474871607555 1.0 0.2950736562012891 3 Q9ULM6,P05556 2 +Guanylate kinase activity 0.7372501019991891 1.5964925149998357 0.1103788755717114 1.0 0.2960092798052278 2 Q9UDY2 1 +Protein homodimerization activity 0.4098782229874241 1.584048213795022 0.1131827477440239 1.0 0.3017611128108908 132 P06280,O94813,Q92692,P02786,Q14849,Q9Y624,Q9UHY1,P42892,Q8IY95,Q14108,Q06481,P16278,Q8TCG1 13 +Quaternary ammonium group binding 0.6650355264494293 1.567849341995024 0.1169162965006915 1.0 0.3049177012738036 11 Q14108 1 +Protein demethylase activity 0.8177338357757515 1.5497728956490502 0.1211960347311253 1.0 0.3148199786641185 4 Q8NB78 1 +Mannose binding 0.8141076308202637 1.546995561239141 0.1218643159948533 1.0 0.3152997382089063 6 P11717,P35613,O75503 3 +Sodium ion transmembrane transporter activity 0.8105023951369257 1.5335931948304886 0.1251297635272983 1.0 0.3177181342582382 6 P55011,P08195,Q9H2J7,P05026 4 +Nuclear import signal receptor activity 0.6660832042223214 1.529357774950776 0.1261757741706866 1.0 0.3194819602302433 10 Q8TEX9,Q9UI26,Q96P70,O00410 4 +Long chain fatty acid transporter activity 0.7205222358221177 1.5215527164200628 0.1281211928544081 1.0 0.3225290260273132 2 P28288 1 +Glycolipid binding 0.8098528845239442 1.5195070533065247 0.1286349139936407 1.0 0.3231983195524228 4 P50897 1 +Demethylase activity 0.7605080927890466 1.517552080527857 0.1291273548579266 1.0 0.3237252055623283 7 Q8NB78 1 +Molecular carrier activity 0.5345416968461694 1.501392098155237 0.1332541764755519 1.0 0.332243682837705 26 Q8TEX9,Q9C0E2,Q96P70,P55060,O00410,Q9UI26,Q8N4V1,Q5J8M3 8 +Phosphatidylinositol monophosphate phosphatase activity 0.7135862913096738 1.4904239692561496 0.1361127939953827 1.0 0.3371969126223542 2 Q9Y217 1 +Nadp binding 0.5949128702359757 1.4773432752467976 0.1395836432894093 1.0 0.3427816776824666 16 Q9UBM7,Q14739 2 +Phosphatidylcholine binding 0.704954250371696 1.4721036664382028 0.1409928855754822 1.0 0.3444942671445163 8 Q14108 1 +Oxidoreductase activity acting on a sulfur group of donors oxygen as acceptor 0.7974522534099047 1.4718048905727916 0.1410735725883218 1.0 0.3444942671445163 4 Q6ZRP7 1 +Histone h3 methyl lysine 9 demethylase activity 0.7074663402692825 1.4629359346834765 0.1434849100083834 1.0 0.3464894863906149 2 Q7LBC6 1 +Membrane insertase activity 0.7869817760017462 1.4568189992854153 0.1451663499271944 1.0 0.3487243668446277 5 Q5J8M3 1 +Phospholipid binding 0.4508903162129859 1.4547173381220218 0.1457475306214126 1.0 0.3487243668446277 61 Q14108,P50897,Q06481,Q8WTV0 4 +Endoribonuclease activity 0.5731210557661455 1.4513270421908375 0.1466888146480349 1.0 0.3496932619763027 18 O00584 1 +Nucleoside diphosphate kinase activity 0.789777817031146 1.4422413177292024 0.1492343083420158 1.0 0.3544399004510588 4 P15531,P23919 2 +Histone methyltransferase activity 0.6274724313603701 1.439514707830071 0.1500047458750359 1.0 0.3544399004510588 12 Q9H7B4,Q9BV86,Q99873 3 +Fad binding 0.6536036165116719 1.4347286096971237 0.151364448240052 1.0 0.3562802175181008 9 Q8NB78,Q15392 2 +Kinetochore binding 0.7009383924928586 1.433597498575498 0.1516871577578333 1.0 0.3563964931823689 2 Q7Z460 1 +Phosphotransferase activity phosphate group as acceptor 0.6944312401961471 1.428926858771082 0.1530252567628305 1.0 0.3588937676595881 8 Q9Y3D8,Q9UDY2,Q14168,P15531,P23919,P00568 6 +Rna strand annealing activity 0.7752058290892189 1.4119212805512205 0.1579731410116867 1.0 0.367851742641499 5 P51114,Q15056,Q06787 3 +Endopeptidase regulator activity 0.521434297997194 1.4015292677365712 0.161055861757384 1.0 0.3730316940171027 24 P05067 1 +1 4 alpha oligoglucan phosphorylase activity 0.7722448979591816 1.372210360554663 0.1699979610497854 1.0 0.3860751501458179 3 Q13126,P06737 2 +Glutamate receptor binding 0.6794329998433257 1.367224100720229 0.1715550733333337 1.0 0.3863692843293043 8 Q13501,Q15334 2 +Vitamin transmembrane transporter activity 0.7627210816259696 1.364251924117831 0.1724882911506653 1.0 0.3878012614835648 5 P04062 1 +Protein carrier chaperone 0.7624375651922886 1.3540736866195695 0.1757128701582115 1.0 0.3930181521205967 6 Q5J8M3 1 +Nuclease activity 0.451341940934664 1.3515039365881547 0.1765340597416129 1.0 0.3941787909299029 54 O00584,Q9UQ84,Q8IV08,Q9Y2L1,Q66K74,Q96C86 6 +Exonuclease activity 0.4969304248661145 1.3157781031437707 0.1882485307641415 1.0 0.410163459340514 30 Q9UQ84,Q8IV08,Q9Y2L1,Q96C86 4 +Aminopeptidase activity 0.5814554945672009 1.3089927568309987 0.1905368042744637 1.0 0.4134109696737116 14 Q9UIQ6 1 +Metalloaminopeptidase activity 0.6067402099631125 1.3060065207172398 0.1915503400931824 1.0 0.4142315812297012 11 Q9UIQ6 1 +Cation transmembrane transporter activity 0.4421745074923973 1.299831832195513 0.1936586128314599 1.0 0.4174025021973613 56 P55011,P61421,O43772,Q9HD20,P05026,P08195,Q9Y487,Q93034,Q13423,Q9UM00,Q8N4V1,P51790,O43808,Q93050,Q9H2J7 15 +Ionotropic glutamate receptor binding 0.7472429790711606 1.2970934356725292 0.194599039874612 1.0 0.4174025021973613 6 Q13501,Q15334 2 +Magnesium ion transmembrane transporter activity 0.7531052563378412 1.296986893121283 0.1946356965848477 1.0 0.4174025021973613 3 Q8N4V1 1 +Potassium ion transmembrane transporter activity 0.7515675073346166 1.2909436401993184 0.1967232213642782 1.0 0.4198479225188524 3 P55011 1 +Active ion transmembrane transporter activity 0.4831480206309655 1.278391361764158 0.201111468320112 1.0 0.4275653370008056 33 P55011,P61421,Q9HD20,P05026,P08195,P51790,O15439,Q9H2J7 8 +P type calcium transporter activity 0.7480100456000256 1.2769644190177607 0.2016148092835794 1.0 0.4275653370008056 3 P20020 1 +Calcium dependent cysteine type endopeptidase activity 0.6658506731946174 1.2758021665712502 0.202025461510567 1.0 0.4275653370008056 2 P17655 1 +Peptidase regulator activity 0.4951085992878022 1.2754824098583812 0.2021385462518639 1.0 0.4275653370008056 28 P05067 1 +Amyloid beta binding 0.6527457604269511 1.2570778491702974 0.2087254472414814 1.0 0.4354847731246269 8 P30533,Q99471,Q8WTV0,Q9UHV9 4 +Procollagen proline 4 dioxygenase activity 0.7415987842245331 1.251777845207618 0.2106508251700982 1.0 0.4367069571093929 3 O15460 1 +Peptidyl proline 4 dioxygenase activity 0.7415987842245331 1.251777845207618 0.2106508251700982 1.0 0.4367069571093929 3 O15460 1 +Nucleoside monophosphate kinase activity 0.6907256958713226 1.2438964706256872 0.2135376684973735 1.0 0.4414732674422248 7 Q9Y3D8,Q9UDY2,Q14168,P23919,P00568 5 +Eukaryotic initiation factor 4e binding 0.7393406490651773 1.2429095224539295 0.2139011762741076 1.0 0.4414732674422248 3 O00571 1 +Vitamin d receptor binding 0.7392961582928013 1.2427348116970114 0.2139655713370292 1.0 0.4414732674422248 3 Q13573 1 +Threonine type peptidase activity 0.6083356140768129 1.2385376838689408 0.2155167581664718 1.0 0.4430225963248093 9 P49721 1 +Nad dependent protein deacetylase activity 0.738208911703877 1.2384655187028546 0.2155434998359797 1.0 0.4430225963248093 3 Q13547 1 +Nucleotide transmembrane transporter activity 0.5796482881459148 1.2183037131049967 0.2231085795713758 1.0 0.4552951295165479 12 Q9H2D1,O15439,O43808,Q9BSK2 4 +Organophosphate ester transmembrane transporter activity 0.5796482881459148 1.2183037131049967 0.2231085795713758 1.0 0.4552951295165479 12 Q9H2D1,O15439,O43808,Q9BSK2 4 +Cysteine type peptidase activity 0.477045496606982 1.2168997008962723 0.2236423794495599 1.0 0.4556713481284782 32 Q99538 1 +Ribosomal small subunit binding 0.5774797273441087 1.208228432178631 0.2269594081995023 1.0 0.4609892029472758 12 P15531,Q15056,P46199,O00571 4 +Amide binding 0.3978759877394156 1.1999063253164828 0.2301757231226946 1.0 0.4630757716169533 90 Q9H3P7,Q9UIQ6,O00410,P30533,P42892,P55786,Q92947,Q8TEX9,Q8WTV0,P04439,O14773,P24390,P10321,P01889,Q6P179,Q15392,Q99471,Q03519,Q9Y680,Q9NXR7 20 +Ribonuclease activity 0.4584250324764858 1.19986111088729 0.2301932855963093 1.0 0.4630757716169533 37 Q9UQ84,O00584,Q9Y2L1,Q96C86 4 +Gdp dissociation inhibitor activity 0.7193931887608522 1.198582902232335 0.2306901697238195 1.0 0.4630757716169533 5 P43487 1 +Procollagen proline dioxygenase activity 0.726570722615804 1.1982295950109556 0.2308276468949537 1.0 0.4630757716169533 4 P13674,O15460 2 +Phosphatidylinositol 4 phosphate binding 0.6470828233374154 1.1915510347448623 0.2334373342983031 1.0 0.4654469173164944 2 P22059 1 +Calcium ion binding 0.4190819437918047 1.1877135006142534 0.2349463030065657 1.0 0.4677404261382621 62 Q02818,Q14126,O94813,Q9Y680,P80303,Q9BRK5,Q9NWM8,P13693,Q14257,O43852 10 +Threonine type endopeptidase activity 0.6356447469755057 1.1863670819913763 0.235477365564606 1.0 0.4680180119924707 8 P49721 1 +Identical protein binding 0.3159049084199093 1.174633493655976 0.2401413773091341 1.0 0.4751811168605627 382 P05067,Q9UHX1,P06280,Q92692,P02786,Q8TBC4,Q8IY95,P42892,P54132,P11717,Q14108,Q06481,P16278,P83916,Q8IXK0,O94813,P07686,Q8IWA4,Q66K74,Q13501,P35790,Q9UQB8,O00148,Q14849,Q9BRK5,Q9Y624,Q9UNS1,P67870,Q9UHY1,O43464,Q96C86,Q99873,Q8TCG1 33 +Fibroblast growth factor binding 0.7198891140732864 1.1724624419708622 0.2410114426225367 1.0 0.4761801836057392 4 Q92896 1 +Annealing activity 0.5918738189725226 1.1669172674743935 0.243243781880811 1.0 0.4790996917323273 9 P51114,Q15056,P54132,Q06787 4 +Protein tyrosine kinase binding 0.5429272235983028 1.1638432771164655 0.2444875302611917 1.0 0.4801381618382441 15 Q13501,Q9UDY2,P05556 3 +Calcium channel regulator activity 0.6397388820889487 1.1586616562667342 0.2465941261128708 1.0 0.4824246847050478 2 P30626 1 +Adenylate kinase activity 0.7102040816326506 1.1287135137260118 0.2590187066869771 1.0 0.4989505844972188 3 Q9Y3D8,P00568 2 +Double stranded rna binding 0.4578112541133444 1.1229475837659402 0.2614597566457992 1.0 0.501224335897154 34 Q15056,P02786 2 +Cytokine binding 0.7006376040556475 1.1222432496200978 0.2617590281794186 1.0 0.501224335897154 6 O00165,Q9ULM6,P05556 3 +Atpase binding 0.4805844336446019 1.1145969095937878 0.2650231952664375 1.0 0.5052488985781206 23 P05026,P11233,Q8IXB1,Q9Y487,Q92542,Q93050 6 +Kinesin binding 0.6159472439153054 1.1049328531152018 0.2691886855672143 1.0 0.5095738221161831 8 Q15334,Q96EK5,O43663 3 +Pdz domain binding 0.5544538424134584 1.1011653491381768 0.2708246996118912 1.0 0.5114757029286575 12 Q9Y624,Q9UQB8,P51790 3 +Passive transmembrane transporter activity 0.4726894585755371 1.1006820660199108 0.2710350542359681 1.0 0.5114757029286575 24 Q9C0H2 1 +Palmitoyltransferase activity 0.7003682532791187 1.0973381055744973 0.2724936191642095 1.0 0.5121379974376383 4 O15269 1 +Misfolded protein binding 0.5683624519577611 1.097176506716896 0.2725642409675775 1.0 0.5121379974376383 10 Q8IXB1,P48723 2 +Nucleocytoplasmic carrier activity 0.5059070147120538 1.0894564408906668 0.2759526536186507 1.0 0.5151799617282483 18 Q8TEX9,Q9C0E2,Q96P70,P55060,O00410,Q9UI26,P52294 7 +Antigen binding 0.6489200574648771 1.079434642883947 0.2803940145193895 1.0 0.5216775819771005 7 P10321,Q15392,P01889 3 +Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amides 0.5618669245461796 1.068322968102548 0.2853748514178054 1.0 0.5267820728512487 10 Q13510 1 +Oxidoreductase activity acting on single donors with incorporation of molecular oxygen 0.616891064871484 1.056794558020468 0.2906053585017254 1.0 0.5314858169512622 2 Q9BV57 1 +Heat shock protein binding 0.4235170685300698 1.0500647466734911 0.2936883455558621 1.0 0.5356218218249569 46 P55011,Q15185,Q8IXB1,P48723,P02786,O60884,Q12907 7 +Transition metal ion binding 0.3742146724347126 1.0387733637788263 0.2989101520171484 1.0 0.5421124314747727 150 O60888,P05067,Q13501,Q5W0Z9,Q10472,Q9UIQ6,Q8IXK0,Q9NUD5,Q5VT66,Q9Y2K7,Q8NB78,P42892,O75976,P54132,Q14527,Q12899,P55786,Q06481 18 +Enzyme activator activity 0.3909188311552212 1.0365661219060311 0.2999381088040633 1.0 0.5432212415006925 73 P05067,Q4KMP7,P10619,P17900,P43487,Q15334,Q9Y263 7 +Protein transmembrane transporter activity 0.5448457584020833 1.025178060131347 0.3052791784762356 1.0 0.5488207101417653 11 O60830,O14925,O96008,Q99595 4 +Hydrolase activity acting on ester bonds 0.3649991959303874 1.0240717234925156 0.3058013990617736 1.0 0.5488207101417653 131 P35790,O00584,Q8NHP8,P11117,Q8IV08,P50897,P38571,P15586 8 +Ubiquitin like protein conjugating enzyme activity 0.5910691950319236 1.0023539083083173 0.3161726947958405 1.0 0.5617018992013298 8 P49427 1 +Integrin binding 0.5097697647330798 0.9974960464887463 0.3185237918558687 1.0 0.56233672096163 15 P09429,Q9Y2I1,Q9Y624,Q96AC1,P05556 5 +Four way junction dna binding 0.6671462812599553 0.9971861548867084 0.3186741599993707 1.0 0.56233672096163 6 P54132,P26583 2 +G protein coupled receptor binding 0.4658361733864874 0.9956811284390664 0.3194051022058914 1.0 0.56233672096163 22 P11233,Q07021 2 +Oxidative rna demethylase activity 0.6030191758465964 0.9954150852144652 0.3195344247240415 1.0 0.56233672096163 2 Q6P6C2 1 +Hormone binding 0.6658973322030443 0.9925433117268622 0.3209325623705978 1.0 0.5640108643278431 6 P42892 1 +Organic anion transmembrane transporter activity 0.464748843566554 0.9892250864100056 0.3225530271159369 1.0 0.5660957568764223 22 P08195,Q9H2D1,O15439,O43808 4 +Protein methyltransferase activity 0.486821958080497 0.9861890920955022 0.3240403309563184 1.0 0.56717931753965 18 Q9H7B4,Q9BV86,Q99873 3 +Peptide antigen binding 0.6569017344566296 0.959162301579093 0.3374769885891417 1.0 0.5813342049144529 6 P10321,Q15392,P01889 3 +Nucleobase containing compound transmembrane transporter activity 0.5089691443245291 0.9551487691181356 0.3395024691737811 1.0 0.584051741164394 14 Q9H2D1,O15439,O43808,Q9BSK2 4 +Protein transporter activity 0.5087055007769969 0.9538649453166348 0.340152009693121 1.0 0.5843981826611723 14 Q9HD20,Q99595,O14925,O96008,O60830 5 +Macromolecule transmembrane transporter activity 0.5200336428751307 0.9414189911369774 0.3464901851474471 1.0 0.5913916249113496 12 O60830,O14925,O96008,Q99595 4 +Protein kinase activity 0.3983174292801622 0.93294936364779 0.3508461133396539 1.0 0.5972491269020881 57 Q13501,Q13177,P25440,Q12802,O96013,P67870,P48729,P42345,Q9UHY1,Q9H2G2,P31751,Q9BVS4,Q15375,P11717,Q13546 15 +Organic cation transmembrane transporter activity 0.6546261871522044 0.922995112158314 0.3560097524359473 1.0 0.6036888389811123 4 O43772 1 +Protein dimerization activity 0.3697438931949994 0.887694464130738 0.3747051245154591 1.0 0.628848754656575 173 P06865,P06280,O94813,Q92692,O95831,P02786,Q14849,Q9Y624,Q8TBC4,Q9UHY1,P42892,Q8IY95,Q14108,Q06481,P16278,Q8TCG1 16 +Endonuclease activity 0.4340815975750398 0.8797052994423569 0.3790189777811861 1.0 0.6324394681115412 28 Q9UQ84,O00584 2 +Translation elongation factor activity 0.506556763369601 0.8792427291217569 0.3792696810300806 1.0 0.6324394681115412 12 Q05639,Q9Y450,P26641,O00178,P63241,Q7Z2Z2,P49411 7 +Tumor necrosis factor receptor superfamily binding 0.6374361550575608 0.8482899252679718 0.3962765269633848 1.0 0.6541070774180426 3 Q9NXR7 1 +Oxidoreductase activity acting on a sulfur group of donors 0.4438377738176133 0.8421995942043334 0.3996762409149048 1.0 0.6551612726483459 21 Q8IXB1,Q9UHG3,O43396,O95881,Q6ZRP7 5 +Poly g binding 0.6248848323579221 0.8414343131577622 0.4001046694290513 1.0 0.6551612726483459 5 O14979,Q06787 2 +Camp binding 0.5675234598123262 0.8408496680166104 0.4004321582060826 1.0 0.6551612726483459 2 P10644 1 +Camp dependent protein kinase inhibitor activity 0.5675234598123262 0.8408496680166104 0.4004321582060826 1.0 0.6551612726483459 2 P10644 1 +Camp dependent protein kinase regulator activity 0.5675234598123262 0.8408496680166104 0.4004321582060826 1.0 0.6551612726483459 2 P10644 1 +Phosphoric ester hydrolase activity 0.398765404045419 0.8378101901315531 0.4021373147497848 1.0 0.6571266396412524 42 P11117 1 +Dystroglycan binding 0.6313600015360392 0.8358453870505593 0.4032418893153875 1.0 0.6574969194769879 4 Q7Z460 1 +Prenyltransferase activity 0.6309787964408502 0.8344292484884219 0.404039141125547 1.0 0.6577615980370954 4 Q92696 1 +Thioesterase binding 0.5646674826601435 0.8286155356660241 0.4073219941711723 1.0 0.6614543965120905 2 P60953 1 +P type transmembrane transporter activity 0.6152142472862535 0.805786722367095 0.4203658352012183 1.0 0.6725853363219493 5 P20020,P05026 2 +Proteasome binding 0.495886647522107 0.7781251069540003 0.4364952627727214 1.0 0.6890917949826014 10 P46379,O95456,Q16186,P54578 4 +Protein carboxyl o methyltransferase activity 0.6177109147165156 0.7745062667239246 0.4386314637428279 1.0 0.6903563821939767 3 O60725 1 +Enzyme inhibitor activity 0.376268530187724 0.7740782130885323 0.4388845405205572 1.0 0.6903563821939767 60 P05067,Q06481,O94813 3 +Flavin adenine dinucleotide binding 0.4194561901569537 0.7712037113949124 0.4405861946845362 1.0 0.6909746428003672 24 Q8NB78,Q15392 2 +Cell adhesion mediator activity 0.4409155155907264 0.7707295434055814 0.4408672567560625 1.0 0.6909746428003672 19 Q14126,Q9NYL9,Q9UQB8,P35613 4 +Smad binding 0.4842411513106026 0.7532587097597204 0.4512944656664532 1.0 0.7022529632804954 11 Q00577,Q9H6Z4,Q13573,Q96AC1,O95373 5 +Solute cation symporter activity 0.607130912322741 0.7467545991432722 0.4552117054342277 1.0 0.7050370613958233 4 Q9H2J7 1 +Cadherin binding involved in cell cell adhesion 0.4797166709101649 0.7333369304037 0.4633529559018057 1.0 0.7130121415575733 11 Q9NYL9,Q9UQB8,Q96HC4 3 +Zinc ion binding 0.3325725625257631 0.7144120376697035 0.4749724305679641 1.0 0.7227118430112313 109 Q13501,Q5W0Z9,Q9UIQ6,Q8IXK0,Q9NUD5,Q9Y2K7,Q8NB78,P42892,O75976,P54132,Q14527,Q12899,P55786,Q03164,P38398 15 +Disulfide oxidoreductase activity 0.4341631289647121 0.7042408214027677 0.4812828131786024 1.0 0.728065879796865 18 Q8IXB1,O95881,Q6ZRP7,O43396 4 +Nucleoside triphosphatase regulator activity 0.3689830285518566 0.6985787546380611 0.484815324716249 1.0 0.7317120178587833 59 Q02818,Q4KMP7,Q12802,O94813,P80303,P55010,Q96HS1,Q9Y2L1,P43487,Q6IAA8,O95373,Q15334 12 +Snap receptor activity 0.5149674260791053 0.6951875705974466 0.4869377606717235 1.0 0.7331604780354858 8 P51809,Q86Y82 2 +Folic acid binding 0.5936913408962418 0.6866903567783995 0.4922778750565895 1.0 0.7362571536242147 3 P04818 1 +Polyubiquitin modification dependent protein binding 0.4668725072822312 0.6772325805428681 0.4982583992175986 1.0 0.7394285659456031 11 Q13501 1 +Nitrite reductase activity 0.5907228478113333 0.6760196583465415 0.4990281639506908 1.0 0.7394285659456031 3 Q5VT66 1 +Oxidoreductase activity acting on other nitrogenous compounds as donors cytochrome as acceptor 0.5907228478113333 0.6760196583465415 0.4990281639506908 1.0 0.7394285659456031 3 Q5VT66 1 +Metalloendopeptidase activity 0.4493455265318084 0.6689983761427112 0.5034965138239467 1.0 0.7435554405735294 14 O43847,P42892 2 +Tap binding 0.5740506130289864 0.6575547524048395 0.5108242775709901 1.0 0.7526721558786115 5 P10321,P01889 2 +Dna polymerase activity 0.570776386948583 0.6486209160013012 0.5165834327389773 1.0 0.7568817935860972 6 Q15185,Q9NRG0 2 +Exoribonuclease activity 0.4180470428500032 0.6469174763578143 0.5176853544196436 1.0 0.7576450080395233 19 Q9ULM6,Q9NVH0,Q9Y3B8,Q9NQT5,Q9Y2L1,Q15024,Q96C86,Q9Y3B2 8 +Beta tubulin binding 0.4516212168146288 0.63113449773149 0.5279525863468968 1.0 0.7683595676298587 12 Q66K74,O75347,Q9HC35,P50402 4 +Cell cell adhesion mediator activity 0.4217380970411478 0.6152699839406203 0.5383764368161681 1.0 0.7763957448659753 17 Q14126,Q9UQB8,P35613 3 +Amp binding 0.5583853739513334 0.6030451648531251 0.546478643806732 1.0 0.7846484699219409 5 P17858,P06737 2 +Kinase activity 0.3404714621733179 0.5896151707066761 0.5554486785094459 1.0 0.794194163131927 91 Q13177,O96013,P31751,P11717,Q13546,Q9Y3D8,P25440,Q15375,Q9H2G2,Q9BVS4,P23919,Q15120,Q13501,P35790,Q12802,P15531,Q5SY16,Q9UDY2,P67870,P48729,P42345,Q9UHY1,P17858 23 +Oxidized dna binding 0.5513276292689209 0.5821385461623959 0.560473363165992 1.0 0.7978791108825911 6 P54132,P20585 2 +Calcium ion transmembrane transporter activity 0.4441120252789277 0.5798231640980903 0.5620338749511404 1.0 0.7983574868587006 11 Q93034,Q9UM00,P08195 3 +Purine nucleotide transmembrane transporter activity 0.4528070803848285 0.576638426691754 0.5641837350684602 1.0 0.800539271522603 9 O15439,O43808 2 +Protein deacetylase activity 0.5541872508336816 0.5607522125520612 0.5749664679493882 1.0 0.8067726134557969 4 Q13547 1 +Catalytic activity acting on dna 0.3416645312934768 0.5592355131402917 0.5760009993307875 1.0 0.8067726134557969 71 Q15185,Q9UQ84,Q8IV08,Q02880,Q9H4L7,P54132,Q14527,Q66K74,Q9NRG0,Q2NKX8 10 +Myosin binding 0.446690290313411 0.5523695960618061 0.5806951569133174 1.0 0.811603949212182 9 P11233 1 +Atpase coupled cation transmembrane transporter activity 0.4254827155524356 0.536932375480815 0.5913143266067673 1.0 0.8202913637183241 13 P61421,Q9HD20,P05026 3 +Symporter activity 0.5347268584890015 0.5269716601520212 0.5982132688220667 1.0 0.8245984170655126 6 Q9H2J7 1 +Cyclic nucleotide binding 0.5410371580236806 0.5170128812473033 0.6051471668410264 1.0 0.8306441111165247 4 P10644,P09543,P13861 3 +Cyclin dependent protein serine threonine kinase regulator activity 0.484700122399023 0.5063181634295619 0.6126333141231441 1.0 0.8356420937411925 2 P11802 1 +Transcription coactivator binding 0.4704202366381066 0.4544947786525209 0.6494727491568841 1.0 0.8659636655425121 2 P62829 1 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 0.3662048361220332 0.4531453488402918 0.6504440824754463 1.0 0.8659983754307745 24 P13674,Q9Y2K7,Q8NB78,O60568,O15460,P30519 6 +Cis regulatory region sequence specific dna binding 0.3543673790816256 0.44481357847506 0.6564544807862784 1.0 0.870820593026762 37 Q13547,P05067,P53999,P42345,Q96JB3,Q9H7B4,Q9Y2W1 7 +Acidic amino acid transmembrane transporter activity 0.5195918367346889 0.4366762482894795 0.6623461568857445 1.0 0.8733057518493537 3 Q9UJS0,Q15758 2 +L aspartate transmembrane transporter activity 0.5195918367346889 0.4366762482894795 0.6623461568857445 1.0 0.8733057518493537 3 Q9UJS0,Q15758 2 +Ubiquitin like modifier activating enzyme activity 0.5071268664843234 0.4350045223410287 0.6635591448736249 1.0 0.873727394179391 5 Q8TBC4 1 +Peptidyl proline dioxygenase activity 0.499928826495479 0.4129549568835733 0.6796396152576514 1.0 0.885364693602375 5 P13674,O15460 2 +Exoribonuclease activity producing 5 phosphomonoesters 0.382837388063481 0.4112756478231746 0.6808704240078984 1.0 0.8860828671719556 16 Q9ULM6,Q9NVH0,Q9NQT5,Q9Y3B8,Q9Y2L1,Q15024 6 +Nadplus kinase activity 0.4532843737250099 0.3954203239505963 0.692532712297746 1.0 0.8960185595484956 2 Q53H12 1 +Atpase coupled transmembrane transporter activity 0.3651170513602916 0.3952914026286449 0.6926278435773647 1.0 0.8960185595484956 20 P61421,Q9HD20,P05026,P08183,O15439,Q03519,P20020 7 +Tpr domain binding 0.4944875459371142 0.3728529279740187 0.7092579077721521 1.0 0.9067375605243984 4 P08238,Q9UNE7,P07900 3 +3 5 exodeoxyribonuclease activity 0.4843116328549737 0.3708664172963973 0.7107370293290902 1.0 0.9075391598024212 6 P27695,Q9Y3B8,Q07864 3 +Protein domain specific binding 0.3192287997551659 0.3648995446248116 0.7151863942444847 1.0 0.9075391598024212 144 Q13501,P05067,P11279,Q9UQB8,P67870,P26368,Q9Y624,P51790,P08236,O00170,Q96PU8,P27348,Q14739 13 +Actinin binding 0.483080889617936 0.3631256674348929 0.716511011559221 1.0 0.9075391598024212 5 Q16527 1 +Poly purine tract binding 0.3802935091979461 0.362504802848421 0.7169748351032832 1.0 0.9075391598024212 14 Q96EP5,O14979,Q06787 3 +Phosphatidylinositol binding 0.3428472989381597 0.3545430051895034 0.7229319808310815 1.0 0.9099452731696238 36 Q06481 1 +Histone lysine n methyltransferase activity 0.4746630462303927 0.3433582222036389 0.7313289850085907 1.0 0.9111103474022062 6 Q9H7B4 1 +Lysine n methyltransferase activity 0.4746630462303927 0.3433582222036389 0.7313289850085907 1.0 0.9111103474022062 6 Q9H7B4 1 +Ubiquitin binding 0.3458828887101638 0.3393432499295711 0.7343511647304073 1.0 0.9125400280134204 24 Q13501,Q9Y263 2 +Dna polymerase binding 0.387989371450911 0.3355925272033774 0.7371781599520084 1.0 0.91376456328652 9 Q15185 1 +Lamin binding 0.4704883145615638 0.3317264489373209 0.7400958271500868 1.0 0.914833387863586 6 Q5SNT2,Q14739 2 +Abc type transporter activity 0.4407424166097195 0.3285437020828544 0.7425006068581665 1.0 0.9161867859343718 7 O15439,Q9HD20,P08183,Q03519 4 +Modification dependent protein binding 0.3308412314673918 0.328275141991848 0.7427036375100153 1.0 0.9161867859343718 40 Q13501,P25440,P83916,Q7Z4V5,Q9NXR7,Q99543,Q03164,Q9ULM3 8 +Protein phosphorylated amino acid binding 0.4616691353123651 0.307715090405922 0.7582991360583287 1.0 0.9301706863732354 6 Q9UPN6 1 +Dna directed dna polymerase activity 0.4702292580189358 0.3057000549515318 0.7598330314646451 1.0 0.9301706863732354 4 Q9NRG0 1 +Dna secondary structure binding 0.3738225818371199 0.3049552046818841 0.7604002696885499 1.0 0.9301706863732354 11 Q03164,P54132,P26583 3 +Guanyl nucleotide exchange factor activity 0.3403801725314349 0.3030116413446796 0.7618809899074506 1.0 0.931108538743501 26 Q02818,Q12802,P80303,Q9Y2L1,Q6IAA8 5 +Mitogen activated protein kinase binding 0.4687662541359474 0.3018503491098007 0.762766146882768 1.0 0.931317467729522 4 Q99873 1 +N methyltransferase activity 0.3626288885525982 0.2921527059449695 0.7701698700479478 1.0 0.9385995425631064 14 Q9H7B4,Q99873 2 +Collagen binding 0.4264328187773714 0.2875768593050401 0.7736706605181962 1.0 0.9411068482422834 7 Q92791,P05556 2 +Transketolase or transaldolase activity 0.465714285714281 0.2843996393462852 0.7761041353537514 1.0 0.9414323651174824 3 P37837,A1L0T0 2 +Thiamine pyrophosphate binding 0.4657142857142802 0.2843996393462835 0.7761041353537528 1.0 0.9414323651174824 3 Q02218,A1L0T0 2 +Vinculin binding 0.4481209150326816 0.2687074729689281 0.7881548006317312 1.0 0.9525058943686536 5 Q9Y490,P12814,P35221,P46939 4 +L ascorbic acid binding 0.4156751780861533 0.2583165921038716 0.796162582055751 1.0 0.958629738689473 7 O60568,P13674,O15460 3 +Rna stem loop binding 0.3876646708077446 0.253026189795091 0.8002479750222622 1.0 0.9626599256725368 8 Q96EP5,O00571,Q06787 3 +Vitamin b6 binding 0.3513477054607931 0.249603240666755 0.802894192212152 1.0 0.962685991488857 14 O15269 1 +Sirna binding 0.4443186552974699 0.2330771100268973 0.8157015290061151 1.0 0.9679179083493472 3 Q06787 1 +Nedd8 specific protease activity 0.442448979591831 0.2288661828948968 0.8189729251268625 1.0 0.9687967423216944 3 Q92905,Q9BT78 2 +Enzyme regulator activity 0.320628216332216 0.2253004878340611 0.8217455201889559 1.0 0.9687967423216944 178 P05067,Q14738,Q13177,Q4KMP7,P61981,O00410,P17900,P55010,O95373,Q9Y263,Q06481,O94813,P10619,Q13217,Q9Y2L1,Q6IAA8,Q02818,Q12802,P80303,P43487,Q96HS1,P20810,Q15334,Q9NR50,P67870,A4D1P6,Q01105,P35251,Q9P287,Q96CS3 30 +Amide transmembrane transporter activity 0.4283367302006994 0.2244115146442296 0.8224371117715612 1.0 0.9687967423216944 6 Q9H2D1,Q03519 2 +Telomeric dna binding 0.3382336848678425 0.2233929203395985 0.8232297138696572 1.0 0.9688551867202464 16 Q00577,Q9Y4R8,Q14103,P54132,P27695 5 +Cullin family protein binding 0.390452876376987 0.2143212936026418 0.8302965139184009 1.0 0.9727822588945144 2 P63208 1 +Dna n glycosylase activity 0.4307880767660293 0.2106842616862544 0.8331336563150757 1.0 0.9732595859535136 4 P23396,P27695,P13051 3 +2 oxoglutarate dependent dioxygenase activity 0.3403070334939226 0.2099721820025811 0.8336893845936155 1.0 0.9732595859535136 14 P13674,Q9Y2K7,Q7LBC6,O60568,O15460 5 +Tat protein binding 0.4275214373213574 0.2036725619172136 0.8386093851590741 1.0 0.9767531082939231 4 P31689,Q12824,P06748 3 +Histone acetyltransferase binding 0.4306122448979558 0.2032635418282209 0.8389290500684004 1.0 0.9767531082939231 3 Q8IXJ6,P04637 2 +Carbon sulfur lyase activity 0.4177486541964706 0.1979499601600469 0.8430842149310527 1.0 0.9795109546655164 5 Q6YP21 1 +Ubiquitin like protein transferase activity 0.3128023445414636 0.1970995350770758 0.8437496472462842 1.0 0.9795109546655164 46 P49427,Q8TBC4,Q93034,Q14527,Q12899,Q16763,P38398 7 +Acetyl coa hydrolase activity 0.3827009383924953 0.1963932395276146 0.8443023873037121 1.0 0.9795109546655164 2 P42765 1 +Ribosomal large subunit binding 0.389818980501381 0.1938647200143103 0.8462818089230439 1.0 0.979744836720034 7 Q9NTK5,O94822,Q16630 3 +Dioxygenase activity 0.3251498838614419 0.17887426802855 0.8580364280382358 1.0 0.981622084816982 17 P13674,Q9Y2K7,Q7LBC6,O60568,O15460 5 +Glucosyltransferase activity 0.381293720296104 0.1745482692659263 0.8614345995530774 1.0 0.9827863122651306 7 P04062 1 +Translation initiation factor activity 0.3132020982758262 0.1694267049407966 0.8654610196329773 1.0 0.98415067200108 36 Q04637,P78344,Q7Z478,Q9Y262,O75822,Q15056,P46199,Q9ULC4,Q14232,P55010,O15372,O75821,P20042,Q9NR50 14 +Beta catenin binding 0.3314238952536812 0.166281529546504 0.8679354009758675 1.0 0.98415067200108 9 Q9Y230,Q86X55,O14745,P49841,Q9Y5K6,P35221,P63208,P18206 8 +Phosphotyrosine residue binding 0.403265306122443 0.1512706911869165 0.8797621882470521 1.0 0.98415067200108 3 P46109,P62993 2 +Carbohydrate derivative transmembrane transporter activity 0.3253023531024347 0.150969523129224 0.8799997573261191 1.0 0.98415067200108 9 O43808 1 +Ubiquitin specific protease binding 0.3671662797280623 0.144760248812531 0.8849001684070645 1.0 0.9856060029549304 7 Q9Y3E7,Q15020 2 +Mismatched dna binding 0.3964883625969803 0.1440182596137701 0.8854860508632036 1.0 0.9856060029549304 4 P12004,P52701,P20585 3 +Dna insertion or deletion binding 0.3964883625969803 0.1440182596137701 0.8854860508632036 1.0 0.9856060029549304 4 P12004,P52701,P20585 3 +Nucleobase containing compound kinase activity 0.3221581562754851 0.1435750165358846 0.8858360701404742 1.0 0.9856060029549304 12 Q9Y3D8,Q9UDY2,P15531,Q5SY16,P23919 5 +Phosphodiesterase i activity 0.355773153814769 0.1422678493929549 0.8868684406453324 1.0 0.985913424212714 2 P27695 1 +Dynein light intermediate chain binding 0.3545491636066867 0.1401096896344346 0.8885733248917342 1.0 0.9868254795786522 2 P63167 1 +G rich strand telomeric dna binding 0.3951020408163209 0.1377186634195132 0.8904627686764139 1.0 0.9873838863554794 3 P22626,P09651 2 +Dicarboxylic acid transmembrane transporter activity 0.3829178586023771 0.1321592723926207 0.8948583144114239 1.0 0.9879729704878358 6 P41440,Q9UJS0,Q02978,O75746,Q15758 5 +Dynein heavy chain binding 0.3496532027743738 0.131737994159657 0.8951915324081012 1.0 0.9879729704878358 2 Q13409 1 +Chemoattractant activity 0.3908245855812549 0.1309794161331343 0.895791590657053 1.0 0.9879729704878358 3 P26583 1 +C4 dicarboxylate transmembrane transporter activity 0.3827614379084987 0.1309642810729283 0.8958035635569646 1.0 0.9879729704878358 5 O75746,Q15758,Q9UJS0,Q02978 4 +Rna polymerase ii ctd heptapeptide repeat kinase activity 0.3821968150265407 0.1208535011758373 0.9038070728103806 1.0 0.9911123439361128 4 Q00534,P06493,P11802 3 +Protein serine threonine kinase activity 0.3013925182594806 0.1200216226297031 0.9044660193895508 1.0 0.9911123439361128 48 Q13501,Q13177,P25440,Q12802,O96013,P67870,P48729,P42345,Q9UHY1,Q9H2G2,P31751,Q9BVS4,Q13546 13 +Poly a binding 0.3124488124488094 0.1177476171032181 0.9062676361898594 1.0 0.9913350224212648 11 Q71RC2,P38919,Q6PJT7,Q07666,P31483,Q92499,Q00839,O14979,Q13310,O00571 10 +Gtp dependent protein binding 0.366906083213111 0.105932649324839 0.9156357893877852 1.0 0.995789049347564 6 P61020 1 +Poly pyrimidine tract binding 0.3072983852466315 0.1050069539050111 0.9163702908106416 1.0 0.995789049347564 14 P26368,Q06787 2 +C3hc4 type ring finger domain binding 0.3718367346938737 0.1040358510387723 0.9171408979122512 1.0 0.995796611888073 3 P31689,P0DMV9 2 +Ubiquitin like protein binding 0.3019201773519094 0.1005266043089457 0.9199262626291485 1.0 0.9971603046287696 28 Q13501,Q9Y263 2 +O methyltransferase activity 0.3550887446884878 0.0887133731323354 0.9293097042199872 1.0 1.0 6 Q8N1G2,O60725 2 +Active transmembrane transporter activity 0.2956435293625731 0.0873016473336314 0.9304317446391824 1.0 1.0 55 P55011,P61421,Q9HD20,P05026,P08195,P08183,P51790,O15439,Q03519,Q9H2J7,P20020 11 +Double stranded telomeric dna binding 0.3511350800155879 0.0843569661923832 0.9327726212840916 1.0 1.0 5 Q00577 1 +Sequence specific mrna binding 0.3320586399830633 0.0831264698797859 0.933750978759665 1.0 1.0 7 P00374,P05455,P04818,Q06787 4 +Supercoiled dna binding 0.3477035302780243 0.0800865284185932 0.936168437094936 1.0 1.0 5 P09429,P26583 2 +Long chain fatty acyl coa binding 0.3084455324357339 0.0771823501754399 0.9384784822781024 1.0 1.0 2 O00154 1 +Protein self association 0.2889108146675045 0.0736362277011112 0.941299843839817 1.0 1.0 9 Q9Y282 1 +Ankyrin binding 0.3444897959183621 0.0734437698509013 0.9414529883137496 1.0 1.0 3 Q15149,Q14315 2 +Ubiquitin ubiquitin ligase activity 0.3410947712418319 0.0722837381944835 0.9423761058814376 1.0 1.0 5 Q9UNE7,Q14139,P61086,Q9UMS4 4 +Proton transmembrane transporter activity 0.2966907943023935 0.0694629474385049 0.9446211250459476 1.0 1.0 31 Q93050,Q13423,P51790 3 +Molecular function regulator 0.316511712756101 0.0674569486782076 0.9462179338973478 1.0 1.0 228 P05067,Q14738,Q5JTV8,Q13177,Q4KMP7,P61981,Q8IXB1,P26583,O00410,P30533,P17900,P55010,Q9UMX5,O95373,Q9Y263,Q06481,Q00577,P05026,O94813,P10619,O60884,Q13217,P54709,Q15375,Q9Y2L1,Q6IAA8,Q02818,Q12802,P80303,P43487,Q96HS1,P20810,Q15334,Q9NR50,P11233,P67870,Q99543,A4D1P6,Q01105,P35251,Q9P287,Q96CS3 42 +Centromeric dna binding 0.3217639853001252 0.0519342310440031 0.9585810986399244 1.0 1.0 4 P43246,P07199,O43264 3 +Histone binding 0.2863462780515129 0.0497969207733504 0.9602842205076354 1.0 1.0 63 P55209,P25440,P83916,Q7Z4V5,Q8IXK0,Q06787,Q9ULM3,Q99733,Q99543,Q8NB78,Q8IWS0,Q13610,Q15020,Q03164,Q92688,Q01105,O95373,Q8WXX5 18 +Rna polymerase binding 0.2861817076792668 0.0495250631557408 0.9605008641931612 1.0 1.0 22 Q9H7B4,Q92688 2 +Mhc protein complex binding 0.289894121116915 0.0483485140558501 0.9614384911097122 1.0 1.0 8 P05026 1 +R smad binding 0.3103307472437777 0.0436854985995771 0.9651550986227396 1.0 1.0 4 Q9UPN9,Q9H6Z4,P09874 3 +Nuclear export signal receptor activity 0.2821933244314775 0.0386450213985841 0.9691734071976166 1.0 1.0 8 Q9C0E2,P55060 2 +Dna binding bending 0.3042757237113357 0.0344339152568465 0.9725311390354584 1.0 1.0 6 P26583 1 +General transcription initiation factor binding 0.2790497267622565 0.0333468225518642 0.973398015506726 1.0 1.0 14 Q9ULM3,P42345 2 +Quinone binding 0.2919559003675027 0.0330912190023823 0.9736018451376184 1.0 1.0 4 O75306,P21912,Q16134 3 +Trna guanine methyltransferase activity 0.2863934020898671 0.0304690028117964 0.9756930140710318 1.0 1.0 4 Q9BV44 1 +Microtubule plus end binding 0.2657182823385084 0.0288017672862789 0.9770226913753406 1.0 1.0 10 O75122,Q14203,Q15691,Q7Z460,Q15555 5 +Methylated histone binding 0.27785047958541 0.0260039936278985 0.9792541530749486 1.0 1.0 17 Q7Z4V5,Q13610,P83916,Q06787 4 +Histone methyltransferase binding 0.2914452518834224 0.0253436874475261 0.979780827565784 1.0 1.0 6 P83916 1 +Androgen receptor binding 0.280866721177434 0.0243452990870846 0.980577180379344 1.0 1.0 7 O94906,O60341,Q13573,P27797,P17844,P51532 6 +Transcription coregulator binding 0.2743378400674633 0.0204498417977383 0.9836845241445192 1.0 1.0 16 Q9UQB8 1 +Tau protein kinase activity 0.2655228758169957 0.0176802162153564 0.985893963355045 1.0 1.0 5 P49840,P49841,Q7KZI7,O75116 4 +Dynein intermediate chain binding 0.2742133224356384 0.0156180656759421 0.9875390931152774 1.0 1.0 6 Q14204,Q86Y56,P43034,P63167,P62826 5 +Rna polymerase i transcription regulatory region sequence specific dna binding 0.2066149448754632 0.0131106430683572 0.9895395199879272 1.0 1.0 4 Q9UIF9,P51532,Q12824 3 +Organic acid binding 0.2815680486410219 0.0073375660084537 0.9941455219020914 1.0 1.0 29 Q9Y2Z4,P13674,P11717,O60568,O15460 5 +Syntaxin binding 0.2677874661212937 0.0067872255847895 0.9945846190731208 1.0 1.0 15 O95721,Q6ZWJ1,Q99747,Q9BVK6 4 diff --git a/msigdb_gomf/selections.json b/msigdb_gomf/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..bfbb75a73d855c99b5407728a455c30fecd0949f --- /dev/null +++ b/msigdb_gomf/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1 4 alpha oligoglucan phosphorylase activity", "1 acylglycerophosphocholine o acyltransferase activity", "1 alkyl 2 acetylglycerophosphocholine esterase activity", "1 phosphatidylinositol 4 kinase activity", "1 phosphatidylinositol binding", "14 3 3 protein binding", "17 beta hydroxysteroid dehydrogenase nadplus activity", "17 beta hydroxysteroid dehydrogenase nadpplus activity", "2 acylglycerol 3 phosphate o acyltransferase activity", "2 iron 2 sulfur cluster binding", "2 oxoglutarate dependent dioxygenase activity", "3 5 dna helicase activity", "3 5 exodeoxyribonuclease activity", "3 5 exonuclease activity", "3 beta hydroxy delta5 steroid dehydrogenase activity", "3 hydroxyacyl coa dehydratase activity", "3 hydroxyacyl coa dehydrogenase activity", "4 iron 4 sulfur cluster binding", "5 3 dna helicase activity", "5 3 exodeoxyribonuclease activity", "5 3 exonuclease activity", "5 deoxyribose 5 phosphate lyase activity", "5s rrna binding", "7s rna binding", "7sk snrna binding", "Abc type glutathione s conjugate transporter activity", "Abc type transporter activity", "Abc type xenobiotic transporter activity", "Acetyl coa c acetyltransferase activity", "Acetyl coa c acyltransferase activity", "Acetyl coa hydrolase activity", "Acetylcholine receptor binding", "Acetylgalactosaminyltransferase activity", "Acetylglucosaminyltransferase activity", "Acetyltransferase activity", "Acid amino acid ligase activity", "Acid phosphatase activity", "Acid thiol ligase activity", "Acidic amino acid transmembrane transporter activity", "Actin binding", "Actin filament binding", "Actin monomer binding", "Actinin binding", "Active ion transmembrane transporter activity", "Active transmembrane transporter activity", "Acyl carnitine transmembrane transporter activity", "Acyl coa binding", "Acyl coa dehydrogenase activity", "Acyl coa oxidase activity", "Acylglycerol lipase activity", "Acylglycerol o acyltransferase activity", "Acyltransferase activity", "Acyltransferase acyl groups converted into alkyl on transfer", "Adenosine deaminase activity", "Adenyl nucleotide binding", "Adenyl nucleotide exchange factor activity", "Adenylate cyclase binding", "Adenylate kinase activity", "Adenylyltransferase activity", "Adp binding", "Adp ribose diphosphatase activity", "Adp transmembrane transporter activity", "Adrenergic receptor binding", "Alanine transmembrane transporter activity", "Alcohol binding", "Alcohol dehydrogenase activity zinc dependent", "Alcohol dehydrogenase nad p plus activity", "Alcohol dehydrogenase nadpplus activity", "Aldehyde dehydrogenase nad p plus activity", "Aldehyde lyase activity", "Alditol nadpplus 1 oxidoreductase activity", "Aldo keto reductase nadp activity", "Alkali metal ion binding", "Alpha actinin binding", "Alpha catenin binding", "Alpha glucosidase activity", "Alpha tubulin binding", "Amide binding", "Amide transmembrane transporter activity", "Amidine lyase activity", "Amino acid binding", "Amino acid cation symporter activity", "Amino acid sodium symporter activity", "Amino acid transmembrane transporter activity", "Aminoacyl trna editing activity", "Aminoacylase activity", "Aminopeptidase activity", "Ammonium transmembrane transporter activity", "Amp activated protein kinase activity", "Amp binding", "Amyloid beta binding", "Anaphase promoting complex binding", "Androgen receptor binding", "Androstan 3 alpha 17 beta diol dehydrogenase activity", "Anion cation symporter activity", "Anion channel activity", "Anion sodium symporter activity", "Anion transmembrane transporter activity", "Ankyrin binding", "Ankyrin repeat binding", "Annealing activity", "Antigen binding", "Antioxidant activity", "Antiporter activity", "Apolipoprotein a i binding", "Apolipoprotein binding", "Apolipoprotein receptor binding", "Arachidonate coa ligase activity", "Arginine binding", "Armadillo repeat domain binding", "Aromatic amino acid transmembrane transporter activity", "Arp2 3 complex binding", "Arrestin family protein binding", "Aryl hydrocarbon receptor binding", "Arylesterase activity", "Arylsulfatase activity", "Aspartic endopeptidase activity intramembrane cleaving", "Aspartic type endopeptidase inhibitor activity", "Aspartic type peptidase activity", "Atp dependent activity", "Atp dependent activity acting on dna", "Atp dependent activity acting on rna", "Atp dependent chromatin remodeler activity", "Atp dependent dna dna annealing activity", "Atp dependent peptidase activity", "Atp dependent protein binding", "Atp hydrolysis activity", "Atp transmembrane transporter activity", "Atpase activator activity", "Atpase binding", "Atpase coupled cation transmembrane transporter activity", "Atpase coupled inorganic anion transmembrane transporter activity", "Atpase coupled intramembrane lipid transporter activity", "Atpase coupled ion transmembrane transporter activity", "Atpase coupled lipid transmembrane transporter activity", "Atpase coupled transmembrane transporter activity", "Atpase inhibitor activity", "Atpase regulator activity", "Axon guidance receptor activity", "Azole transmembrane transporter activity", "Basal transcription machinery binding", "Beta 1 3 galactosyltransferase activity", "Beta 2 adrenergic receptor binding", "Beta 2 microglobulin binding", "Beta catenin binding", "Beta galactosidase activity", "Beta n acetylhexosaminidase activity", "Beta tubulin binding", "Bh domain binding", "Bh3 domain binding", "Bhlh transcription factor binding", "Bile acid binding", "Bile acid transmembrane transporter activity", "Biotin binding", "Box h aca snorna binding", "Branched chain amino acid transmembrane transporter activity", "Bubble dna binding", "C acetyltransferase activity", "C acyltransferase activity", "C c chemokine binding", "C methyltransferase activity", "C palmitoyltransferase activity", "C x c chemokine binding", "C x3 c chemokine binding", "C2h2 zinc finger domain binding", "C3hc4 type ring finger domain binding", "C4 dicarboxylate transmembrane transporter activity", "Cadherin binding", "Cadherin binding involved in cell cell adhesion", "Calcium cation antiporter activity", "Calcium channel regulator activity", "Calcium dependent cysteine type endopeptidase activity", "Calcium dependent phospholipid binding", "Calcium dependent protein binding", "Calcium dependent protein kinase activity", "Calcium dependent protein serine threonine phosphatase activity", "Calcium independent phospholipase a2 activity", "Calcium ion binding", "Calcium ion transmembrane transporter activity", "Calmodulin binding", "Calmodulin dependent protein kinase activity", "Camp binding", "Camp dependent protein kinase activity", "Camp dependent protein kinase inhibitor activity", "Camp dependent protein kinase regulator activity", "Carbohydrate binding", "Carbohydrate derivative transmembrane transporter activity", "Carbohydrate kinase activity", "Carbohydrate phosphatase activity", "Carbon carbon lyase activity", "Carbon nitrogen ligase activity with glutamine as amido n donor", "Carbon nitrogen lyase activity", "Carbon oxygen lyase activity", "Carbon sulfur lyase activity", "Carbonyl reductase nadph activity", "Carboxy lyase activity", "Carboxylic acid binding", "Carboxylic ester hydrolase activity", "Carboxypeptidase activity", "Cardiolipin binding", "Cargo adaptor activity", "Cargo receptor activity", "Carnitine o acyltransferase activity", "Catalytic activity acting on a glycoprotein", "Catalytic activity acting on a nucleic acid", "Catalytic activity acting on a rrna", "Catalytic activity acting on a trna", "Catalytic activity acting on dna", "Catalytic activity acting on rna", "Cation cation antiporter activity", "Cation channel activity", "Cation chloride symporter activity", "Cation transmembrane transporter activity", "Ccr chemokine receptor binding", "Ccr3 chemokine receptor binding", "Ccr5 chemokine receptor binding", "Cdp alcohol phosphatidyltransferase activity", "Cell adhesion mediator activity", "Cell adhesion molecule binding", "Cell adhesive protein binding involved in bundle of his cell purkinje myocyte communication", "Cell cell adhesion mediator activity", "Cell matrix adhesion mediator activity", "Centromeric dna binding", "Ceramide binding", "Channel inhibitor activity", "Channel regulator activity", "Chaperone binding", "Chemoattractant activity", "Chemokine binding", "Chemokine receptor binding", "Chemorepellent activity", "Chitin binding", "Chloride channel inhibitor activity", "Chloride channel regulator activity", "Cholesterol binding", "Chondroitin sulfate binding", "Chromatin binding", "Chromatin dna binding", "Chromo shadow domain binding", "Cis regulatory region sequence specific dna binding", "Cis trans isomerase activity", "Class i dna apurinic or apyrimidinic site endonuclease activity", "Clathrin binding", "Clathrin heavy chain binding", "Clathrin light chain binding", "Co smad binding", "Coa hydrolase activity", "Cobalamin binding", "Collagen binding", "Collagen binding involved in cell matrix adhesion", "Complement binding", "Complement component c1q complex binding", "Complement component c3b binding", "Copper chaperone activity", "Copper ion binding", "Core promoter sequence specific dna binding", "Coreceptor activity", "Coreceptor activity involved in wnt signaling pathway", "Coreceptor activity involved in wnt signaling pathway planar cell polarity pathway", "Cullin family protein binding", "Cuprous ion binding", "Cxcr chemokine receptor binding", "Cyclic nucleotide binding", "Cyclic nucleotide dependent protein kinase activity", "Cyclic nucleotide phosphodiesterase activity", "Cyclin binding", "Cyclin dependent protein kinase activity", "Cyclin dependent protein serine threonine kinase regulator activity", "Cyclohydrolase activity", "Cyclosporin a binding", "Cysteine type endopeptidase activity", "Cysteine type endopeptidase inhibitor activity", "Cysteine type endopeptidase inhibitor activity involved in apoptotic process", "Cysteine type endopeptidase regulator activity involved in apoptotic process", "Cysteine type exopeptidase activity", "Cysteine type peptidase activity", "Cytidylyltransferase activity", "Cytochrome b5 reductase activity acting on nad p h", "Cytokine activity", "Cytokine binding", "Cytokine receptor activity", "Cytokine receptor binding", "Cytoskeletal anchor activity", "Cytoskeletal motor activity", "Cytoskeletal protein binding", "Cytoskeleton nuclear membrane anchor activity", "D loop dna binding", "D threo aldose 1 dehydrogenase activity", "D1 dopamine receptor binding", "Damaged dna binding", "Deacetylase activity", "Dead h box rna helicase binding", "Deaminase activity", "Death domain binding", "Death receptor activity", "Death receptor binding", "Demethylase activity", "Deoxynucleoside kinase activity", "Deoxyribonuclease activity", "Diacylglycerol binding", "Diacylglycerol kinase activity", "Dicarboxylic acid transmembrane transporter activity", "Dihydropyrimidinase activity", "Dioxygenase activity", "Dipeptidase activity", "Dipeptidyl peptidase activity", "Diphosphotransferase activity", "Disordered domain specific binding", "Disulfide oxidoreductase activity", "Dna apurinic or apyrimidinic site endonuclease activity", "Dna binding bending", "Dna binding transcription activator activity", "Dna binding transcription factor activity", "Dna binding transcription factor binding", "Dna binding transcription repressor activity", "Dna clamp loader activity", "Dna directed dna polymerase activity", "Dna dna annealing activity", "Dna helicase activity", "Dna insertion or deletion binding", "Dna methyltransferase activity", "Dna n glycosylase activity", "Dna polymerase activity", "Dna polymerase binding", "Dna replication origin binding", "Dna secondary structure binding", "Dna topoisomerase activity", "Dna translocase activity", "Dolichyl diphosphooligosaccharide protein glycotransferase activity", "Dolichyl phosphate mannose protein mannosyltransferase activity", "Dopamine receptor binding", "Double stranded methylated dna binding", "Double stranded rna adenosine deaminase activity", "Double stranded rna binding", "Double stranded telomeric dna binding", "Dttp diphosphatase activity", "Dynactin binding", "Dynein complex binding", "Dynein heavy chain binding", "Dynein intermediate chain binding", "Dynein light chain binding", "Dynein light intermediate chain binding", "Dystroglycan binding", "E box binding", "Efflux transmembrane transporter activity", "Electron transfer activity", "Endodeoxyribonuclease activity", "Endodeoxyribonuclease activity producing 5 phosphomonoesters", "Endonuclease activity", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Endopeptidase activator activity", "Endopeptidase activity", "Endopeptidase regulator activity", "Endopolyphosphatase activity", "Endoribonuclease activity", "Endoribonuclease activity producing 5 phosphomonoesters", "Enoyl coa hydratase activity", "Enzyme activator activity", "Enzyme inhibitor activity", "Enzyme regulator activity", "Ephrin receptor activity", "Ephrin receptor binding", "Epidermal growth factor receptor binding", "Epoxide hydrolase activity", "Er retention sequence binding", "Erbb 3 class receptor binding", "Estradiol 17 beta dehydrogenase activity", "Estrogen receptor binding", "Ether hydrolase activity", "Eukaryotic initiation factor 4e binding", "Exodeoxyribonuclease activity", "Exogenous protein binding", "Exonuclease activity", "Exonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Exopeptidase activity", "Exoribonuclease activity", "Exoribonuclease activity producing 5 phosphomonoesters", "Extracellular matrix binding", "Fad binding", "Fatty acid binding", "Fatty acid derivative binding", "Fatty acid ligase activity", "Fatty acid synthase activity", "Fatty acid transmembrane transporter activity", "Ferric iron binding", "Ferrous iron binding", "Fibroblast growth factor binding", "Fibroblast growth factor receptor binding", "Fibronectin binding", "Fk506 binding", "Flap endonuclease activity", "Flavin adenine dinucleotide binding", "Flippase activity", "Floppase activity", "Fmn binding", "Folic acid binding", "Folic acid transmembrane transporter activity", "Four way junction dna binding", "Four way junction helicase activity", "Frizzled binding", "Fructose 2 6 bisphosphate 2 phosphatase activity", "Fructose 6 phosphate binding", "Fructose binding", "G protein activity", "G protein alpha subunit binding", "G protein beta gamma subunit complex binding", "G protein beta subunit binding", "G protein coupled chemoattractant receptor activity", "G protein coupled glutamate receptor binding", "G protein coupled opioid receptor activity", "G protein coupled receptor activity", "G protein coupled receptor binding", "G protein coupled serotonin receptor binding", "G quadruplex dna binding", "G quadruplex rna binding", "G rich strand telomeric dna binding", "Galactosidase activity", "Galactoside binding", "Galactosyltransferase activity", "Gamma aminobutyric acid transmembrane transporter activity", "Gamma catenin binding", "Gamma tubulin binding", "Ganglioside binding", "Gated channel activity", "Gdp binding", "Gdp dissociation inhibitor activity", "General transcription initiation factor activity", "General transcription initiation factor binding", "Glucocorticoid receptor binding", "Glucose binding", "Glucosidase activity", "Glucosyltransferase activity", "Glucuronosyltransferase activity", "Glutamate receptor binding", "Glutathione disulfide oxidoreductase activity", "Glutathione oxidoreductase activity", "Glutathione peroxidase activity", "Glutathione transferase activity", "Glutathione transmembrane transporter activity", "Glyceraldehyde 3 phosphate dehydrogenase nadplus non phosphorylating activity", "Glycerophospholipid flippase activity", "Glycine binding", "Glycolipid binding", "Glycolipid mannosyltransferase activity", "Glycosaminoglycan binding", "Glycosphingolipid binding", "Glycosyltransferase activity", "Gpi anchor binding", "Gpi linked ephrin receptor activity", "Growth factor activity", "Growth factor binding", "Growth factor receptor binding", "Gtp dependent protein binding", "Gtpase activating protein binding", "Gtpase activator activity", "Gtpase activity", "Gtpase binding", "Gtpase inhibitor activity", "Guanyl nucleotide binding", "Guanyl nucleotide exchange factor activity", "Guanylate kinase activity", "Guanylyltransferase activity", "H4 histone acetyltransferase activity", "Heat shock protein binding", "Helicase activity", "Heme transmembrane transporter activity", "Heparin binding", "Hexokinase activity", "Hexosaminidase activity", "Hexosyltransferase activity", "High density lipoprotein particle binding", "Histone acetyltransferase binding", "Histone arginine n methyltransferase activity", "Histone binding", "Histone deacetylase activity h3 k14 specific", "Histone deacetylase binding", "Histone deacetylase regulator activity", "Histone h3 di monomethyl lysine 9 demethylase activity", "Histone h3 methyl lysine 36 demethylase activity", "Histone h3 methyl lysine 4 demethylase activity", "Histone h3 methyl lysine 9 demethylase activity", "Histone kinase activity", "Histone lysine n methyltransferase activity", "Histone methyltransferase activity", "Histone methyltransferase activity h3 k36 specific", "Histone methyltransferase activity h3 k4 specific", "Histone methyltransferase activity h4 k20 specific", "Histone methyltransferase binding", "Histone serine kinase activity", "Histone threonine kinase activity", "Hormone activity", "Hormone binding", "Hormone receptor binding", "Hsp70 protein binding", "Hsp90 protein binding", "Hyaluronic acid binding", "Hyalurononglucosaminidase activity", "Hydro lyase activity", "Hydrolase activity acting on acid anhydrides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amidines", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amidines", "Hydrolase activity acting on ester bonds", "Hydrolase activity acting on ether bonds", "Hydrolase activity acting on glycosyl bonds", "Hydrolase activity hydrolyzing n glycosyl compounds", "Hydrolase activity hydrolyzing o glycosyl compounds", "Hydroxymethyl formyl and related transferase activity", "I smad binding", "Identical protein binding", "Immune receptor activity", "Immunoglobulin binding", "Immunoglobulin receptor binding", "Importin alpha family protein binding", "Inorganic anion transmembrane transporter activity", "Inorganic diphosphatase activity", "Inorganic molecular entity transmembrane transporter activity", "Inorganic phosphate transmembrane transporter activity", "Inositol phosphate phosphatase activity", "Inositol polyphosphate 5 phosphatase activity", "Inositol tetrakisphosphate phosphatase activity", "Inositol trisphosphate phosphatase activity", "Insulin binding", "Insulin like growth factor binding", "Insulin like growth factor ii binding", "Insulin like growth factor receptor binding", "Insulin receptor binding", "Insulin receptor substrate binding", "Integrin binding", "Interleukin 1 binding", "Interleukin 1 receptor binding", "Interleukin 2 receptor binding", "Interleukin 6 receptor binding", "Intermediate filament binding", "Intracellular calcium activated chloride channel activity", "Intraciliary transport particle b binding", "Intramembrane lipid transporter activity", "Intramolecular oxidoreductase activity", "Intramolecular oxidoreductase activity interconverting aldoses and ketoses", "Intramolecular oxidoreductase activity transposing c c bonds", "Intramolecular transferase activity", "Intramolecular transferase activity phosphotransferases", "Intronic transcription regulatory region sequence specific dna binding", "Ion gated channel activity", "Ion transmembrane transporter activity", "Ionotropic glutamate receptor binding", "Iron ion binding", "Iron ion transmembrane transporter activity", "Isocitrate dehydrogenase activity", "Isomerase activity", "Isopeptidase activity", "Isoprenoid binding", "Jun kinase binding", "Jun kinase kinase kinase activity", "K48 linked polyubiquitin modification dependent protein binding", "K63 linked polyubiquitin modification dependent protein binding", "Keratin filament binding", "Kinase activator activity", "Kinase activity", "Kinase binding", "Kinase inhibitor activity", "Kinase regulator activity", "Kinesin binding", "Kinetochore binding", "L alanine transmembrane transporter activity", "L amino acid transmembrane transporter activity", "L ascorbic acid binding", "L aspartate transmembrane transporter activity", "L glutamine transmembrane transporter activity", "L lactate dehydrogenase activity", "L leucine transmembrane transporter activity", "L ornithine transmembrane transporter activity", "L serine transmembrane transporter activity", "Lactate dehydrogenase activity", "Lactate transmembrane transporter activity", "Lamin binding", "Laminin 1 binding", "Laminin binding", "Large ribosomal subunit rrna binding", "Leucine binding", "Leucine zipper domain binding", "Leukotriene c4 synthase activity", "Ligand gated ion channel activity", "Ligase activity", "Ligase activity forming carbon carbon bonds", "Ligase activity forming carbon nitrogen bonds", "Ligase activity forming carbon oxygen bonds", "Ligase activity forming carbon sulfur bonds", "Ligase activity forming phosphoric ester bonds", "Lim domain binding", "Lipase activator activity", "Lipase activity", "Lipase binding", "Lipase inhibitor activity", "Lipid binding", "Lipid kinase activity", "Lipid transfer activity", "Lipid transporter activity", "Lipopolysaccharide binding", "Lipopolysaccharide immune receptor activity", "Lipoprotein particle receptor activity", "Lipoprotein particle receptor binding", "Long chain acyl coa dehydrogenase activity", "Long chain fatty acid binding", "Long chain fatty acid coa ligase activity", "Long chain fatty acid transporter activity", "Long chain fatty acyl coa binding", "Low density lipoprotein particle binding", "Low density lipoprotein particle receptor binding", "Lrr domain binding", "Lyase activity", "Lys48 specific deubiquitinase activity", "Lys63 specific deubiquitinase activity", "Lysine acetylated histone binding", "Lysine n methyltransferase activity", "Lysophosphatidic acid binding", "Lysophosphatidic acid phosphatase activity", "Lysophospholipase activity", "Lysophospholipid acyltransferase activity", "M7g 5 pppn diphosphatase activity", "Macrolide binding", "Macromolecule transmembrane transporter activity", "Magnesium ion binding", "Magnesium ion transmembrane transporter activity", "Malate dehydrogenase activity", "Manganese ion binding", "Manganese ion transmembrane transporter activity", "Mannose binding", "Mannosyltransferase activity", "Map kinase kinase activity", "Map kinase kinase kinase activity", "Map kinase phosphatase activity", "Map kinase scaffold activity", "Map kinase tyrosine serine threonine phosphatase activity", "Mdm2 mdm4 family protein binding", "Medium chain fatty acid coa ligase activity", "Membrane insertase activity", "Metal cluster binding", "Metal dependent deubiquitinase activity", "Metal ion proton antiporter activity", "Metal ion transmembrane transporter activity", "Metalloaminopeptidase activity", "Metallocarboxypeptidase activity", "Metallochaperone activity", "Metallodipeptidase activity", "Metalloendopeptidase activity", "Metalloexopeptidase activity", "Metallopeptidase activity", "Methyl cpg binding", "Methylated histone binding", "Mhc class i protein binding", "Mhc class ib protein binding", "Mhc class ii protein complex binding", "Mhc protein binding", "Mhc protein complex binding", "Microfilament motor activity", "Microtubule binding", "Microtubule minus end binding", "Microtubule motor activity", "Microtubule plus end binding", "Minor groove of adenine thymine rich dna binding", "Minus end directed microtubule motor activity", "Mirna binding", "Misfolded protein binding", "Mismatch repair complex binding", "Mismatched dna binding", "Mitochondrial ribosome binding", "Mitochondrion targeting sequence binding", "Mitogen activated protein kinase binding", "Mitogen activated protein kinase kinase kinase binding", "Mitogen activated protein kinase p38 binding", "Modification dependent protein binding", "Modified amino acid binding", "Modified amino acid transmembrane transporter activity", "Molecular adaptor activity", "Molecular carrier activity", "Molecular function activator activity", "Molecular function inhibitor activity", "Molecular function regulator", "Molecular transducer activity", "Molybdopterin cofactor binding", "Monocarboxylic acid binding", "Monocarboxylic acid transmembrane transporter activity", "Monooxygenase activity", "Monosaccharide binding", "Mrf binding", "Mrna 3 utr au rich region binding", "Mrna 3 utr binding", "Mrna 5 utr binding", "Mrna binding", "Mrna methyltransferase activity", "Muscle alpha actinin binding", "Mutlalpha complex binding", "Myosin binding", "Myosin ii binding", "Myosin v binding", "Myristoyltransferase activity", "N acetylgalactosamine 4 o sulfotransferase activity", "N acetyllactosaminide beta 1 3 n acetylglucosaminyltransferase activity", "N acetyltransferase activity", "N acylsphingosine amidohydrolase activity", "N acyltransferase activity", "N methyltransferase activity", "N6 methyladenosine containing rna binding", "Nad binding", "Nad dependent protein deacetylase activity", "Nad p h oxidase h2o2 forming activity", "Nad p plus protein arginine adp ribosyltransferase activity", "Nad retinol dehydrogenase activity", "Nadh dehydrogenase activity", "Nadh pyrophosphatase activity", "Nadp binding", "Nadp retinol dehydrogenase activity", "Nadph binding", "Nadplus adp ribosyltransferase activity", "Nadplus binding", "Nadplus kinase activity", "Nedd8 specific protease activity", "Nedd8 transferase activity", "Nerve growth factor binding", "Neuroligin family protein binding", "Neurotransmitter receptor regulator activity", "Neurotransmitter transmembrane transporter activity", "Neurotrophin binding", "Neurotrophin receptor activity", "Neurotrophin receptor binding", "Neurotrophin trk receptor binding", "Neutral amino acid transmembrane transporter activity", "Nf kappab binding", "Nitric oxide synthase binding", "Nitric oxide synthase regulator activity", "Nitrite reductase activity", "Non membrane spanning protein tyrosine kinase activity", "Non membrane spanning protein tyrosine phosphatase activity", "Notch binding", "Nuclear export signal receptor activity", "Nuclear import signal receptor activity", "Nuclear localization sequence binding", "Nuclear receptor activity", "Nuclear receptor binding", "Nuclear receptor coactivator activity", "Nuclease activity", "Nucleobase containing compound kinase activity", "Nucleobase containing compound transmembrane transporter activity", "Nucleobase transmembrane transporter activity", "Nucleocytoplasmic carrier activity", "Nucleoside binding", "Nucleoside diphosphatase activity", "Nucleoside diphosphate kinase activity", "Nucleoside kinase activity", "Nucleoside monophosphate kinase activity", "Nucleoside triphosphatase regulator activity", "Nucleoside triphosphate diphosphatase activity", "Nucleosomal dna binding", "Nucleosome binding", "Nucleotidase activity", "Nucleotide diphosphatase activity", "Nucleotide phosphatase activity acting on free nucleotides", "Nucleotide sugar transmembrane transporter activity", "Nucleotide transmembrane transporter activity", "Nucleotidyltransferase activity", "O acetyltransferase activity", "O acyltransferase activity", "O methyltransferase activity", "O palmitoyltransferase activity", "Oleate transmembrane transporter activity", "Oligopeptide binding", "Oligopeptide transmembrane transporter activity", "Oligosaccharide binding", "Oligosaccharyl transferase activity", "Omega peptidase activity", "Opsonin binding", "Organic acid binding", "Organic acid sodium symporter activity", "Organic acid transmembrane transporter activity", "Organic anion transmembrane transporter activity", "Organic cation transmembrane transporter activity", "Organic hydroxy compound transmembrane transporter activity", "Organophosphate ester transmembrane transporter activity", "Oxidative phosphorylation uncoupler activity", "Oxidative rna demethylase activity", "Oxidized dna binding", "Oxidoreductase activity", "Oxidoreductase activity acting on a heme group of donors", "Oxidoreductase activity acting on a sulfur group of donors", "Oxidoreductase activity acting on a sulfur group of donors disulfide as acceptor", "Oxidoreductase activity acting on a sulfur group of donors nad p as acceptor", "Oxidoreductase activity acting on a sulfur group of donors oxygen as acceptor", "Oxidoreductase activity acting on ch oh group of donors", "Oxidoreductase activity acting on ch or ch2 groups", "Oxidoreductase activity acting on diphenols and related substances as donors", "Oxidoreductase activity acting on metal ions", "Oxidoreductase activity acting on metal ions nad or nadp as acceptor", "Oxidoreductase activity acting on nad p h", "Oxidoreductase activity acting on nad p h heme protein as acceptor", "Oxidoreductase activity acting on nad p h oxygen as acceptor", "Oxidoreductase activity acting on nad p h quinone or similar compound as acceptor", "Oxidoreductase activity acting on other nitrogenous compounds as donors", "Oxidoreductase activity acting on other nitrogenous compounds as donors cytochrome as acceptor", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water", "Oxidoreductase activity acting on peroxide as acceptor", "Oxidoreductase activity acting on single donors with incorporation of molecular oxygen", "Oxidoreductase activity acting on the aldehyde or oxo group of donors", "Oxidoreductase activity acting on the aldehyde or oxo group of donors disulfide as acceptor", "Oxidoreductase activity acting on the aldehyde or oxo group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors", "Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors oxygen as acceptor", "Oxidoreductase activity acting on the ch nh group of donors", "Oxidoreductase activity acting on the ch nh group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch nh2 group of donors", "Oxidoreduction driven active transmembrane transporter activity", "Oxo acid lyase activity", "Oxygen binding", "Oxygen sensor activity", "Oxysterol binding", "P type calcium transporter activity", "P type potassium transmembrane transporter activity", "P type transmembrane transporter activity", "P53 binding", "Palmitoyl coa hydrolase activity", "Palmitoyl protein hydrolase activity", "Palmitoyltransferase activity", "Passive transmembrane transporter activity", "Pattern recognition receptor activity", "Pdz domain binding", "Pentosyltransferase activity", "Peptidase activator activity", "Peptidase activator activity involved in apoptotic process", "Peptidase activity", "Peptidase regulator activity", "Peptide alpha n acetyltransferase activity", "Peptide antigen binding", "Peptide binding", "Peptide hormone binding", "Peptide hormone receptor binding", "Peptide lysine n acetyltransferase activity", "Peptide n acetyltransferase activity", "Peptide receptor activity", "Peptide transmembrane transporter activity", "Peptidoglycan binding", "Peptidyl proline 4 dioxygenase activity", "Peptidyl proline dioxygenase activity", "Peroxiredoxin activity", "Peroxisome proliferator activated receptor binding", "Peroxisome targeting sequence binding", "Phosphatase activator activity", "Phosphatase activity", "Phosphatase binding", "Phosphatase inhibitor activity", "Phosphatase regulator activity", "Phosphate ion binding", "Phosphatidic acid binding", "Phosphatidyl phospholipase b activity", "Phosphatidylcholine binding", "Phosphatidylcholine floppase activity", "Phosphatidylcholine transfer activity", "Phosphatidylcholine transporter activity", "Phosphatidylethanolamine binding", "Phosphatidylethanolamine flippase activity", "Phosphatidylglycerol binding", "Phosphatidylinositol 3 4 5 trisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate 5 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 5 bisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate phosphatase activity", "Phosphatidylinositol 3 kinase binding", "Phosphatidylinositol 3 kinase regulator activity", "Phosphatidylinositol 3 kinase regulatory subunit binding", "Phosphatidylinositol 3 phosphate binding", "Phosphatidylinositol 4 5 bisphosphate 5 phosphatase activity", "Phosphatidylinositol 4 5 bisphosphate binding", "Phosphatidylinositol 4 5 bisphosphate phosphatase activity", "Phosphatidylinositol 4 phosphate binding", "Phosphatidylinositol 5 phosphate binding", "Phosphatidylinositol binding", "Phosphatidylinositol bisphosphate binding", "Phosphatidylinositol bisphosphate phosphatase activity", "Phosphatidylinositol kinase activity", "Phosphatidylinositol monophosphate phosphatase activity", "Phosphatidylinositol phosphate 4 phosphatase activity", "Phosphatidylinositol phosphate 5 phosphatase activity", "Phosphatidylinositol phosphate binding", "Phosphatidylinositol phosphate phosphatase activity", "Phosphatidylinositol transfer activity", "Phosphatidylinositol trisphosphate phosphatase activity", "Phosphatidylserine binding", "Phosphodiesterase i activity", "Phosphofructokinase activity", "Phospholipase a2 activity", "Phospholipase a2 inhibitor activity", "Phospholipase activity", "Phospholipase binding", "Phospholipase c activity", "Phospholipase d activity", "Phospholipase inhibitor activity", "Phospholipid binding", "Phospholipid transfer activity", "Phospholipid transporter activity", "Phosphoprotein binding", "Phosphoprotein phosphatase activity", "Phosphoric diester hydrolase activity", "Phosphoric ester hydrolase activity", "Phosphorus oxygen lyase activity", "Phosphoserine residue binding", "Phosphotransferase activity for other substituted phosphate groups", "Phosphotransferase activity nitrogenous group as acceptor", "Phosphotransferase activity phosphate group as acceptor", "Phosphotyrosine residue binding", "Plus end directed microtubule motor activity", "Poly a binding", "Poly a specific ribonuclease activity", "Poly g binding", "Poly purine tract binding", "Poly pyrimidine tract binding", "Polynucleotide adenylyltransferase activity", "Polypeptide n acetylgalactosaminyltransferase activity", "Polysaccharide binding", "Polysome binding", "Polyubiquitin modification dependent protein binding", "Porin activity", "Potassium channel inhibitor activity", "Potassium channel regulator activity", "Potassium chloride symporter activity", "Potassium ion binding", "Potassium ion transmembrane transporter activity", "Pre mirna binding", "Pre mrna 3 splice site binding", "Pre mrna 5 splice site binding", "Pre mrna binding", "Pre mrna intronic binding", "Prenyltransferase activity", "Primary active transmembrane transporter activity", "Primary mirna binding", "Procollagen proline 4 dioxygenase activity", "Procollagen proline dioxygenase activity", "Profilin binding", "Proline rich region binding", "Promoter specific chromatin binding", "Protease binding", "Proteasome activating activity", "Proteasome binding", "Protein adp ribosylase activity", "Protein antigen binding", "Protein arginine n methyltransferase activity", "Protein arginine omega n asymmetric methyltransferase activity", "Protein arginine omega n monomethyltransferase activity", "Protein binding involved in heterotypic cell cell adhesion", "Protein c terminus binding", "Protein carboxyl o methyltransferase activity", "Protein carrier chaperone", "Protein containing complex binding", "Protein cysteine s stearoyltransferase activity", "Protein deacetylase activity", "Protein demethylase activity", "Protein dimerization activity", "Protein disaggregase activity", "Protein disulfide isomerase activity", "Protein disulfide reductase nad p activity", "Protein domain specific binding", "Protein folding chaperone", "Protein geranylgeranyltransferase activity", "Protein heterodimerization activity", "Protein homodimerization activity", "Protein kinase a binding", "Protein kinase a catalytic subunit binding", "Protein kinase a regulatory subunit binding", "Protein kinase activity", "Protein kinase b binding", "Protein kinase c activity", "Protein kinase c binding", "Protein lipid complex binding", "Protein macromolecule adaptor activity", "Protein membrane adaptor activity", "Protein methyltransferase activity", "Protein n terminus binding", "Protein phosphatase 1 binding", "Protein phosphatase 2a binding", "Protein phosphatase 2b binding", "Protein phosphatase activator activity", "Protein phosphatase binding", "Protein phosphatase regulator activity", "Protein phosphorylated amino acid binding", "Protein prenyltransferase activity", "Protein self association", "Protein serine kinase activity", "Protein serine threonine kinase activator activity", "Protein serine threonine kinase activity", "Protein serine threonine kinase inhibitor activity", "Protein serine threonine phosphatase activity", "Protein serine threonine tyrosine kinase activity", "Protein tag", "Protein transmembrane transporter activity", "Protein transporter activity", "Protein tyrosine kinase activator activity", "Protein tyrosine kinase activity", "Protein tyrosine kinase binding", "Protein tyrosine kinase inhibitor activity", "Protein tyrosine phosphatase activity", "Protein tyrosine serine threonine phosphatase activity", "Protein tyrosine threonine phosphatase activity", "Proteoglycan binding", "Proton channel activity", "Proton transmembrane transporter activity", "Proton transporting atp synthase activity rotational mechanism", "Pseudouridine synthase activity", "Purine nucleotide transmembrane transporter activity", "Pyrimidine nucleotide binding", "Pyrimidine nucleotide sugar transmembrane transporter activity", "Pyrophosphate hydrolysis driven proton transmembrane transporter activity", "Pyruvate dehydrogenase acetyl transferring kinase activity", "Pyruvate dehydrogenase activity", "Quaternary ammonium group binding", "Quaternary ammonium group transmembrane transporter activity", "Quinone binding", "R smad binding", "Racemase and epimerase activity", "Racemase and epimerase activity acting on carbohydrates and derivatives", "Rage receptor binding", "Rdna binding", "Receptor antagonist activity", "Receptor tyrosine kinase binding", "Regulatory rna binding", "Retinal binding", "Retinal dehydrogenase activity", "Retinoic acid binding", "Retinoic acid receptor binding", "Retinoid x receptor binding", "Retromer complex binding", "Ribonuclease activity", "Ribonuclease p activity", "Ribonuclease p rna binding", "Ribonucleoprotein complex binding", "Ribonucleotide binding", "Ribose phosphate diphosphokinase activity", "Ribosomal large subunit binding", "Ribosomal protein s6 kinase activity", "Ribosomal small subunit binding", "Ribosome binding", "Rna 2 o methyltransferase activity", "Rna 7 methylguanosine cap binding", "Rna adenylyltransferase activity", "Rna binding", "Rna binding involved in posttranscriptional gene silencing", "Rna cap binding", "Rna directed dna polymerase activity", "Rna dna hybrid ribonuclease activity", "Rna methyltransferase activity", "Rna polymerase activity", "Rna polymerase binding", "Rna polymerase core enzyme binding", "Rna polymerase i general transcription initiation factor activity", "Rna polymerase i transcription regulatory region sequence specific dna binding", "Rna polymerase ii activity", "Rna polymerase ii c terminal domain binding", "Rna polymerase ii c terminal domain phosphoserine binding", "Rna polymerase ii core promoter sequence specific dna binding", "Rna polymerase ii ctd heptapeptide repeat kinase activity", "Rna polymerase ii ctd heptapeptide repeat phosphatase activity", "Rna polymerase ii general transcription initiation factor activity", "Rna polymerase ii general transcription initiation factor binding", "Rna polymerase ii intronic transcription regulatory region sequence specific dna binding", "Rna polymerase ii specific dna binding transcription factor binding", "Rna polymerase iii transcription regulatory region sequence specific dna binding", "Rna stem loop binding", "Rna strand annealing activity", "Roundabout binding", "Rrna adenine methyltransferase activity", "Rrna binding", "Rrna cytosine methyltransferase activity", "S acyltransferase activity", "S adenosyl l methionine binding", "S adenosylmethionine dependent methyltransferase activity", "S methyltransferase activity", "S100 protein binding", "Salt transmembrane transporter activity", "Scaffold protein binding", "Scavenger receptor activity", "Secondary active transmembrane transporter activity", "Sequence specific dna binding", "Sequence specific mrna binding", "Sequence specific single stranded dna binding", "Serine hydrolase activity", "Serine transmembrane transporter activity", "Serine type carboxypeptidase activity", "Serine type endopeptidase inhibitor activity", "Serine type exopeptidase activity", "Sh2 domain binding", "Sh3 domain binding", "Signal recognition particle binding", "Signal sequence binding", "Signaling adaptor activity", "Signaling receptor binding", "Signaling receptor complex adaptor activity", "Signaling receptor inhibitor activity", "Signaling receptor regulator activity", "Single stranded dna 3 5 exodeoxyribonuclease activity", "Single stranded dna binding", "Single stranded dna endodeoxyribonuclease activity", "Single stranded dna exodeoxyribonuclease activity", "Single stranded dna helicase activity", "Single stranded rna binding", "Single stranded telomeric dna binding", "Sirna binding", "Smad binding", "Small molecule sensor activity", "Small protein activating enzyme binding", "Small ribosomal subunit rrna binding", "Snap receptor activity", "Snare binding", "Snorna binding", "Snrna binding", "Snrnp binding", "Sodium channel inhibitor activity", "Sodium channel regulator activity", "Sodium chloride symporter activity", "Sodium ion binding", "Sodium ion transmembrane transporter activity", "Solute anion antiporter activity", "Solute cation antiporter activity", "Solute cation symporter activity", "Solute proton antiporter activity", "Solute proton symporter activity", "Solute sodium symporter activity", "Spectrin binding", "Sphingolipid binding", "Sphingolipid transfer activity", "Sphingolipid transporter activity", "Sphingomyelin phosphodiesterase activity", "Sphingosine n acyltransferase activity", "Steroid binding", "Steroid dehydrogenase activity", "Steroid dehydrogenase activity acting on the ch oh group of donors nad or nadp as acceptor", "Steroid hormone binding", "Steroid hormone receptor activity", "Sterol binding", "Sterol esterase activity", "Sterol transfer activity", "Sterol transporter activity", "Structural constituent of cytoskeleton", "Structural constituent of eye lens", "Structural constituent of muscle", "Structural constituent of nuclear pore", "Structural constituent of postsynapse", "Structural constituent of postsynaptic actin cytoskeleton", "Structural constituent of presynaptic active zone", "Structural constituent of ribosome", "Structural constituent of synapse", "Structural molecule activity", "Structural molecule activity conferring elasticity", "Succinate transmembrane transporter activity", "Sulfate binding", "Sulfate transmembrane transporter activity", "Sulfatide binding", "Sulfotransferase activity", "Sulfur compound binding", "Sulfur compound transmembrane transporter activity", "Sulfuric ester hydrolase activity", "Sulfurtransferase activity", "Sumo binding", "Sumo ligase activity", "Sumo specific protease activity", "Sumo transferase activity", "Supercoiled dna binding", "Superoxide dismutase activity", "Symporter activity", "Syntaxin 1 binding", "Syntaxin binding", "T cell receptor binding", "Tap binding", "Tap1 binding", "Tat protein binding", "Tau protein binding", "Tau protein kinase activity", "Tbp class protein binding", "Telomerase activity", "Telomerase rna binding", "Telomeric dna binding", "Testosterone dehydrogenase nad p activity", "Testosterone dehydrogenase nadplus activity", "Tetrapyrrole binding", "Tfiib class transcription factor binding", "Tfiid class transcription factor complex binding", "Thiamine pyrophosphate binding", "Thioesterase binding", "Thiol oxidase activity", "Thiolester hydrolase activity", "Thioredoxin disulfide reductase activity", "Threonine type endopeptidase activity", "Threonine type peptidase activity", "Thyroid hormone receptor binding", "Titin binding", "Toll like receptor binding", "Toxic substance binding", "Tpr domain binding", "Transcription coactivator activity", "Transcription coactivator binding", "Transcription coregulator activity", "Transcription coregulator binding", "Transcription corepressor activity", "Transcription corepressor binding", "Transcription elongation regulator activity", "Transcription factor binding", "Transcription regulator activity", "Transcription regulator inhibitor activity", "Transferase activity transferring alkyl or aryl other than methyl groups", "Transferase activity transferring nitrogenous groups", "Transferase activity transferring one carbon groups", "Transferase activity transferring phosphorus containing groups", "Transferase activity transferring sulphur containing groups", "Transferrin receptor binding", "Transforming growth factor beta receptor binding", "Transition metal ion binding", "Transition metal ion transmembrane transporter activity", "Transketolase or transaldolase activity", "Translation activator activity", "Translation elongation factor activity", "Translation factor activity rna binding", "Translation initiation factor activity", "Translation initiation factor binding", "Translation regulator activity", "Translation regulator activity nucleic acid binding", "Translation repressor activity", "Translation repressor activity mrna regulatory element binding", "Translation termination factor activity", "Transmembrane receptor protein kinase activity", "Transmembrane receptor protein tyrosine kinase activity", "Transmembrane transporter binding", "Transporter activity", "Tripeptide transmembrane transporter activity", "Trna binding", "Trna cytosine methyltransferase activity", "Trna guanine methyltransferase activity", "Trna methyltransferase activity", "Trna specific adenosine deaminase activity", "Trna specific ribonuclease activity", "Tropomyosin binding", "Tubulin binding", "Tumor necrosis factor activated receptor activity", "Tumor necrosis factor receptor binding", "Tumor necrosis factor receptor superfamily binding", "Type 1 fibroblast growth factor receptor binding", "Type i transforming growth factor beta receptor binding", "U1 snrna binding", "U2 snrna binding", "U3 snorna binding", "U4 snrna binding", "U6 snrna binding", "Ubiquinol cytochrome c reductase activity", "Ubiquinone binding", "Ubiquitin binding", "Ubiquitin conjugating enzyme binding", "Ubiquitin ligase substrate adaptor activity", "Ubiquitin like modifier activating enzyme activity", "Ubiquitin like protein binding", "Ubiquitin like protein conjugating enzyme activity", "Ubiquitin like protein conjugating enzyme binding", "Ubiquitin like protein ligase activity", "Ubiquitin like protein ligase binding", "Ubiquitin like protein specific isopeptidase activity", "Ubiquitin like protein specific protease activity", "Ubiquitin like protein transferase activity", "Ubiquitin protein transferase activator activity", "Ubiquitin protein transferase inhibitor activity", "Ubiquitin protein transferase regulator activity", "Ubiquitin specific protease binding", "Ubiquitin ubiquitin ligase activity", "Ubiquitination like modification dependent protein binding", "Udp galactose beta n acetylglucosamine beta 1 3 galactosyltransferase activity", "Udp glucosyltransferase activity", "Udp glycosyltransferase activity", "Udp xylosyltransferase activity", "Unfolded protein binding", "Unmethylated cpg binding", "Uridylyltransferase activity", "Vascular endothelial growth factor receptor 2 binding", "Vascular endothelial growth factor receptor binding", "Very long chain fatty acid coa ligase activity", "Vinculin binding", "Virion binding", "Vitamin b6 binding", "Vitamin binding", "Vitamin d binding", "Vitamin d receptor binding", "Vitamin transmembrane transporter activity", "Voltage gated anion channel activity", "Voltage gated calcium channel activity", "Voltage gated calcium channel activity involved in regulation of cytosolic calcium levels", "Voltage gated cation channel activity", "Voltage gated channel activity", "Voltage gated chloride channel activity", "Volume sensitive anion channel activity", "Wd40 repeat domain binding", "Wide pore channel activity", "Ww domain binding", "Xenobiotic transmembrane transporter activity", "Y form dna binding", "Zinc ion binding"], "available_proteins": ["AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABHD10", "ABHD12", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR6", "ADAM17", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC5", "ANAPC7", "ANK3", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3M1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOL2", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARMT1", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG4B", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATPIF1", "ATXN2L", "AUP1", "B4GAT1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAT2", "BCCIP", "BCLAF1", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPTF", "BRCA1", "BRD2", "BRIX1", "BRMS1L", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BYSL", "BZW1", "C1QBP", "C1orf123", "C1orf35", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC47", "CCDC6", "CCDC86", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD3EAP", "CDC23", "CDC27", "CDC34", "CDC37", "CDC42", "CDC5L", "CDC73", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKAL1", "CEBPZ", "CECR2", "CELF1", "CENPB", "CERS2", "CFAP20", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD4", "CHERP", "CHID1", "CHKA", "CHMP3", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT6", "CNOT7", "CNOT9", "CNP", "COIL", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS4", "COPS5", "COPS6", "CORO1B", "CORO1C", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX7A2", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DGCR8", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIAPH1", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPF2", "DPH2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI2", "EDC3", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOB", "ELP1", "ELP2", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "ENSA", "ENY2", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERH", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOSC1", "EXOSC10", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAHD1", "FAM208A", "FAM49B", "FAM98A", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FDFT1", "FDPS", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FOXK1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GIGYF2", "GLA", "GLB1", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLGB1", "GOT1", "GOT2", "GPAA1", "GPATCH4", "GPD2", "GPI", "GPR107", "GPRASP2", "GPS1", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C4", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIC2", "HIF1AN", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOXA10", "HP1BP3", "HPF1", "HPRT1", "HPS6", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMPDH2", "INA", "INCENP", "INF2", "INTS11", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRGQ", "IRS4", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC2", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMP1", "LAMTOR1", "LAMTOR2", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDAH", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3BP", "LGMN", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LUC7L", "LUC7L3", "LYAR", "LYPLA1", "MACF1", "MAGT1", "MAK16", "MAP1B", "MAP1S", "MAP2K1", "MAP4", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARCKSL1", "MARK2", "MARS", "MAT2A", "MATR3", "MAU2", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED16", "METAP2", "METTL13", "MFN1", "MFN2", "MGEA5", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MINPP1", "MKI67", "MLEC", "MMAB", "MMGT1", "MMS19", "MOGS", "MORF4L1", "MOV10", "MPHOSPH10", "MPI", "MPP2", "MPRIP", "MPST", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL39", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL58", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTPN", "MTR", "MYBBP1A", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDUFA10", "NDUFA4", "NDUFA5", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFAF7", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFCD", "NEMF", "NENF", "NES", "NEU1", "NHP2", "NIFK", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NPTN", "NRBP1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP35", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "OAT", "OCLN", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OSBP", "OSBPL11", "OSBPL6", "OSBPL9", "OTUB1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCM1", "PCMT1", "PCNA", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIN4", "PIR", "PISD", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLAA", "PLBD2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1R10", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PPP6R3", "PPT1", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTRH2", "PTRHD1", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RABGGTA", "RABL6", "RAC1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAD51AP1", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM34", "RBM39", "RBM4", "RBM45", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "RECQL5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIOK2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF114", "RNF20", "RNF40", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP1B", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF8", "SCAMP1", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC3A2", "SLC6A15", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMYD3", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX2", "SNX3", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPCS2", "SPCS3", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SQLE", "SQSTM1", "SRCAP", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "SSU72", "STAG2", "STARD3", "STAT3", "STAU1", "STAU2", "STEAP3", "STIP1", "STMN1", "STOML2", "STRAP", "STRBP", "STRN4", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYNCRIP", "SYNE2", "TACO1", "TAF15", "TAGLN2", "TALDO1", "TAMM41", "TAP1", "TAP2", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF25", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TFAM", "TFG", "TFRC", "THG1L", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TK1", "TKT", "TLN1", "TMCO1", "TMED10", "TMED9", "TMEM109", "TMEM192", "TMEM201", "TMEM43", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TNKS1BP1", "TNPO1", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOX4", "TP53", "TP53BP1", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRMT6", "TRMU", "TRNT1", "TROVE2", "TSC2", "TSFM", "TSG101", "TSN", "TSR1", "TSTA3", "TTC1", "TTC21B", "TTC26", "TTC4", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBL5", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UCHL5", "UFC1", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF3B", "UQCR10", "UQCRC1", "UQCRC2", "UROD", "USO1", "USP10", "USP14", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VPS16", "VPS18", "VPS33B", "VPS35", "VPS4B", "VRK1", "VRK3", "WARS", "WBP11", "WDHD1", "WDR1", "WDR12", "WDR3", "WDR33", "WDR36", "WDR4", "WDR43", "WDR45B", "WDR46", "WDR5", "WDR6", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIZ", "WRAP53", "XPNPEP1", "XPO1", "XPO4", "XPO5", "XPO7", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YEATS2", "YEATS4", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBTB10", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZDHHC20", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZMYM4", 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0.3770196158976925 5.1558475294842455e-05 7.414404483649349e-06 0.0005197950164847 0.0001160124341843 +Abnormality of the vasculature of the eye 10 64 2.9745297946778795 0.0029343795768947 16.27912621359223 72.06553398058253 0.403343228775578 0.4479390001832676 5.629952078086087 5.671259209870798 1.3806507490937323 0.3789287537753926 1.3209633213208054e-05 7.647961648212386e-05 0.0039180753854734 0.0303025991867385 +Abnormality of head blood vessel 7 21 2.973616173703194 0.002943129716538 7.512135922330097 24.881067961165048 0.5951213621611695 0.2501622891395578 2.541375726543966 2.628804376839775 1.8399520883426277 0.3043503409762604 4.179116048594872e-07 1.7828164711438355e-06 9.650602468108328e-05 0.0005873508489337 +Abnormal retinal artery morphology 7 19 2.9188647042346743 0.0035130866189614 6.985436893203883 21.733009708737864 0.6882820766413594 0.2247118762866906 2.318097134221824 2.0518941450352677 1.8438290687413053 0.2835525492265039 1.376612939528017e-07 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0.0070543382012846 26.58252427184466 132.13349514563106 0.525484494447878 0.6234130914808526 8.355016250174085 12.686440449515484 0.9112834521434876 0.3703513369566691 0.0078558938828105 0.0026761912601836 0.0030552824248742 0.0028006634860458 +Increased bone mineral density 7 23 2.68813659535787 0.0071851997643039 6.242718446601942 24.75 1.1480702818250033 0.3148175930983396 2.4533156459354677 2.2345749579547443 1.0849696139569316 0.312718333498069 0.312708212996757 9.611170637388942e-05 0.0005084182864372 0.0114081647201376 +Loss of speech 4 16 2.6828204568389884 0.0073004171876867 5.453883495145631 19.1626213592233 0.4726173662677797 0.3013153148889984 2.223071754411353 1.8941045281154043 1.521023928928509 0.3006842241053739 4.993112815839301e-05 5.2354492781690494e-05 0.0033942963153933 0.015487938148487 +Cherry red spot of the macula 6 9 2.655346396774069 0.0079227006005753 4.87621359223301 9.031553398058252 0.4125318500531191 0.1346012745180574 1.6566187440434876 0.4477283705000042 2.101542046986786 0.2228325403979826 9.21605913978827e-12 5.369773771670297e-12 3.399976877027078e-09 4.068112400838954e-07 +Abnormal vascular physiology 9 37 2.639161047826445 0.0083111487955691 12.74757281553398 50.021844660194176 0.816183607478715 0.4136638745601454 4.907827009322534 5.622165606934028 1.2216480011219424 0.371091913776798 0.0519267383076168 0.0268750149441068 0.0095294704033757 0.1357212543450114 +Myoclonus 10 66 2.6380172017389976 0.0083392351629385 19.92718446601942 92.40291262135922 0.7794869182612147 0.4142145469430702 6.660238401732631 11.33633180094438 1.369340457412049 0.3858779422292388 0.0014870684218155 0.0036009286451109 0.0232125183769075 0.0764979945645896 +Arteriosclerosis 5 14 2.595032850229382 0.0094581878651021 4.885922330097087 14.944174757281552 0.0721468675738393 0.2032976413320727 1.852339343238996 2.0572604199467093 1.788928597657784 0.2405012300780825 8.494254101186968e-05 6.7303776327030426e-06 0.0010375816316685 0.0020547334314456 +Abnormal exteroceptive sensation 10 42 2.582310895636743 0.0098141130482498 10.759708737864075 52.02427184466019 0.4941713240335635 0.5557419524937993 3.9194595318694754 5.696566262954939 0.9102536370390476 0.3437672640084617 0.0305051812830626 0.0117351303813186 0.0021288742160214 0.03916050194843 +Abnormality of the lymphatic system 16 122 2.574731837208823 0.0100317830585161 29.699029126213592 145.21601941747574 0.1994066708674118 0.5892027724934705 8.709814742221091 14.879269336886908 1.105110161252099 0.3641956683310547 4.4800362953968704e-05 1.1520218472136222e-06 0.0001954835588119 0.0054682176879853 +Cerebral inclusion bodies 3 12 2.560833711769804 0.010442132349173 3.844660194174758 13.655339805825244 0.5051551663301821 0.4226246963159299 1.8115448621120656 1.6612796655742368 1.090041660052819 0.3107400387490911 0.0005458668398673 0.0002865257018003 0.0081443152876 0.0047299686256361 +Hallucinations 6 36 2.536889270948778 0.0111842323152011 11.20388349514563 45.44660194174757 0.6705549628539956 0.4221278622600144 3.902598644570227 4.462852401771342 1.2595119979903464 0.3693437289960082 0.0128572972549243 0.0029612996216462 0.0111193401215375 0.0033758351477557 +Diarrhea 13 54 2.522480318675005 0.0116530470890421 15.235436893203884 71.36893203883496 -0.0937123546508902 0.4891141680274506 5.321271341758422 8.34189367719314 1.2527606286184891 0.3588826008598239 0.0005304036813053 0.0002113011210802 0.0006318748501255 0.0281281179881479 +Abnormal urine carbohydrate level 2 9 2.5152674444120744 0.0118942118168825 3.883495145631068 11.70631067961165 -0.1388020161424021 0.4168246977061866 1.9096127339504616 1.3287920569685254 1.2303643442685093 0.3136870898203888 0.0003706576678266 0.0027797273347076 0.0329460998536745 0.1665994534041104 +Abnormality of corneal stroma 4 10 2.472686824439001 0.0134101600937617 4.733009708737864 13.131067961165048 0.6716440045814968 0.2233795964932449 1.7589100966397004 2.506749302052849 1.61853564814875 0.2527544669587041 0.0029741493546945 0.0002701034311773 0.0143052966741969 0.0669681114683941 +Abnormal tissue metabolite concentration 4 10 2.42945333783442 0.015121611283424 5.895631067961165 14.650485436893204 0.4799987914691458 0.2340469593783387 2.3926019349714145 2.328417679576543 1.7567023743300048 0.2768423789344761 1.8856680763096997e-05 0.0002865257018003 0.0011317572349641 0.0047299686256361 +Hyperintensity of cerebral white matter on mri 2 14 2.424519650966076 0.0153286537068102 5.844660194174757 19.76456310679612 0.5239793769920946 0.3497882694217939 2.383223245915457 2.1845455756818453 1.3844482033830876 0.3203944687906004 0.0013622028220488 0.0096414106757913 0.0966974979109908 0.066946879618907 +Juvenile onset 6 39 2.421842759736786 0.0154420306373364 10.220873786407768 41.28155339805825 0.3416766536043948 0.3540580800469471 3.658644665705508 2.990007551791468 1.4952530140825149 0.3282418399186692 0.0014196759684226 5.368000360583747e-05 0.0111193401215375 0.0238902452884441 +Abnormal circulating cholesterol concentration 6 24 2.4148498036634773 0.0157416994188968 9.691747572815531 31.70873786407767 0.976903841313624 0.2790879029908041 4.4525142732793395 3.04459115485426 1.5883623188049951 0.3063455707490317 0.0521335433076176 8.922499786531232e-05 0.002300215711815 0.003359715969014 +Progressive visual loss 3 19 2.409685422936097 0.0159662805348153 5.325242718446602 22.429611650485437 0.7316954387450431 0.34231947196034 2.467466703195611 2.985791083259841 1.255625436621734 0.3056268024259221 0.0004573916663925 0.0059312171066033 0.0343914567738469 0.2940815710100106 +Hydrops fetalis 6 35 2.4052093378785004 0.0161632040249766 10.383495145631068 42.85436893203884 0.0422302936304952 0.5660977362192432 5.636524390210048 3.6334683929983864 0.9704238719472263 0.3260500973307448 0.0090901991927659 2.342895000699936e-05 0.0013486610144001 0.0274735672158388 +Abnormality of extrapyramidal motor function 9 61 2.3966683746581148 0.0165448901096543 17.723300970873787 74.23058252427184 0.6611914449106878 0.5008095396366101 5.517064505158221 6.985611887807198 1.1554912414277594 0.3847143245763222 0.0031806147838438 0.0039614528918462 0.028859526477288 0.0114863194297596 +Developmental regression 10 101 2.3843190507361185 0.0171107605266227 25.563106796116504 124.11893203883496 0.1947738024620598 0.6450498639544575 9.98996574521336 10.619999946302212 0.903974587940342 0.3489502357085532 0.000363810561436 0.0056488105818582 0.0382705273981637 0.050220971221445 +Cirrhosis 5 32 2.376670343245371 0.0174696930734274 7.813106796116505 38.04126213592233 -0.1452161322848621 0.4839588586854018 3.471314216064694 3.703939959360424 1.1276079613645364 0.3330627717006385 0.0111951113174208 0.0003289582056801 0.0285890862939352 0.0420494561785451 +Ectopic calcification 7 47 2.373680799991809 0.017611768313152 13.553398058252426 56.53155339805825 0.5275931647443897 0.4410566614950294 4.995100814049753 5.994858194438004 1.2985638579898735 0.3743313818119885 0.0357664341382327 9.832887908238142e-05 0.0103405593254548 0.0581956273714211 +Limb ataxia 4 19 2.3695295307792583 0.0178107326980854 6.597087378640777 24.114077669902912 0.989869123864314 0.3154216467413447 2.5039369509835696 2.8496458430585005 1.1323309577692284 0.292147514752726 0.0029741493546945 0.0002701034311773 0.0143052966741969 0.0669681114683941 +Left ventricular hypertrophy 3 21 2.3544919388946 0.0185480459996796 7.567961165048544 23.54126213592233 0.6997255266541987 0.4097452846499351 3.537969183053948 3.034709621147107 1.2051726960058406 0.3398649994618895 0.0414278249847813 0.1367168788611213 0.0774145056148102 0.4040792503621244 +Abnormal arterial physiology 8 26 2.3469567503486104 0.0189274516749391 6.218446601941747 26.953883495145632 0.6799967252485163 0.4871419269266132 2.869465887610158 2.4604264895945303 0.8630108658008876 0.3264277839815205 0.0732573258319426 0.0599224496562618 0.0067559961712648 0.0331996833734174 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system physiology 11 32 2.20749815613468 0.0272792756733422 9.118932038834952 36.9126213592233 -0.1901538890737912 0.6649866462522597 3.9601082197190185 4.832348111850687 0.6722085787606645 0.2811627344638381 0.5451422660923099 0.4641940615408458 0.0017728440601824 0.0887808365551406 +Abnormal autonomic nervous system physiology 4 25 2.2001747962668365 0.0277944957584994 8.24757281553398 32.320388349514566 0.4638475540870246 0.4509985093876737 3.0051523606495087 3.6502788621576223 1.089960321271389 0.3249871136051702 0.0060673937801388 0.006515948460693 0.0379484136991646 0.0037045029072781 +Tissue ischemia 4 19 2.198325694567541 0.0279259046281827 4.669902912621359 20.01941747572815 0.4670703905456849 0.5376214087969519 2.554791232762714 1.8952192409705757 0.8387891641382008 0.309595447618788 0.0496758524768897 0.1605058634275269 0.0326937613140359 0.1454895561901762 +Ventricular hypertrophy 4 32 2.1947048969220733 0.028184773239039 10.04126213592233 36.45873786407767 1.1361758135608295 0.3518404639351837 4.440080726024568 4.153106961798495 1.0569836433105884 0.3376234863759063 0.078908455169182 0.0664204872480981 0.082698802989994 0.3192032621972422 +Dysarthria 10 127 2.192735678215683 0.0283264285983764 31.643203883495147 157.04611650485438 0.1702243844445948 0.697256008053868 10.646635706694058 15.169441352201568 0.7828174068575321 0.3401561251520427 0.0008812857166949 0.0077540021803948 0.3239383962071096 0.3059893271413337 +Dysmetria 5 44 2.169518877397894 0.0300433127672383 14.618932038834952 55.148058252427184 0.6447099310037795 0.5301040823699991 5.464619727151339 6.3203263646610806 0.9326090127326924 0.3593910006397782 0.0033011735408768 0.0078713338334775 0.0880900807686078 0.0200874294949683 +Dysgraphia 2 14 2.167673074720617 0.0301835694842809 3.888349514563106 14.1747572815534 -0.020954539630261 0.7180644151789357 2.573607681679318 1.633551045654117 0.6042658996811474 0.2627585792299407 0.1908924307699622 0.0663348012473392 0.0870629174096409 0.1566651346062924 +Macroglossia 5 27 2.164009154669258 0.0304636468161507 8.597087378640778 33.800970873786405 0.2378332400826553 0.526108686434358 3.4819634097071916 3.0993577519995683 1.045257905641647 0.335668429128709 0.0135596849536518 0.0785306043043279 0.0385618829400607 0.2305964038641619 +Abnormal vascular morphology 24 180 2.155357079385892 0.0311339023152961 41.94660194174757 223.89077669902912 -0.0948455945909161 0.7884603915060189 13.003997260991705 22.90631431110358 0.5966735379974201 0.2839121328141819 0.0002924553487501 0.0002222905307121 0.0031508689853048 0.0485432517804103 +Abnormal cerebral artery morphology 1 12 2.1535838649887964 0.0312728207331367 3.6893203883495143 15.189320388349516 0.1461288400266414 0.5737075812512653 2.321403685727363 2.2061437876789474 0.9153426901574684 0.3191805767887729 0.0239365913087713 0.0832266786685991 0.3371805301273846 0.2162792749917559 +Dysostosis multiplex 5 7 2.144578269902737 0.0319865812512141 3.983009708737864 7.990291262135922 0.4150973501220912 0.1595724105588133 1.65382835361071 1.246316090990369 1.8479195153421644 0.2123242141003258 2.8801476738141424e-06 3.6856640078126496e-08 4.133905164944655e-07 4.0623087816283454e-05 +Abnormal vertebral morphology 13 86 2.1430653453696764 0.0321078516620449 25.18446601941747 107.1383495145631 0.7050611944944222 0.5078087978506296 8.434496402822974 10.278065304429203 1.0858158093436174 0.3796440707216367 0.0194799622426816 0.001116293772174 0.0051038036776007 0.023325165271838 +Telangiectasia 4 28 2.1410797765744225 0.0322676052427446 7.37378640776699 35.228155339805824 0.4262114587209472 0.5354451219010867 3.552121235933074 4.829257867279929 0.8971455635118568 0.3342182460970163 0.0199622774755299 0.02858940310823 0.1619443288150952 0.2189923594809638 +Abnormal lactate dehydrogenase level 2 15 2.140049978862546 0.0323507279131571 4.143203883495145 17.87621359223301 -0.1889046507521062 0.4455642582293665 2.002759607594022 2.089436499733168 1.1284322896017482 0.2992123479577444 0.0230307909850112 0.0115064399741943 0.1119144158382109 0.4181534738954689 +Macular degeneration 2 12 2.139265208979685 0.0324141956668793 3.5072815533980584 13.201456310679612 0.7081764422831481 0.3007939344006393 1.5711122114355351 1.3240485924903622 1.388921785741595 0.3097317018961461 0.2260688267312995 0.0142951840993497 0.1335053000482259 0.2481167977468243 +Abnormal macrophage morphology 5 6 2.135651482396387 0.032707831786626 2.9150485436893203 5.640776699029126 -0.1129741045260028 0.144980672561322 1.3090672390975422 1.117854819168669 1.9286041303300476 0.1913667515871486 8.918029494024718e-07 5.659119341396245e-09 1.3027979224706197e-06 6.933879980949677e-05 +Foam cells 5 6 2.135651482396387 0.032707831786626 2.9611650485436893 5.398058252427185 -0.064606162326146 0.1366553329191208 1.1817572081322671 0.893230265545378 1.9405286208577948 0.1862104272675829 3.5306643188636324e-08 2.108390609667161e-11 5.371828865194635e-09 3.394440369161991e-07 +Abnormal endocardium morphology 3 13 2.129104249720804 0.033245636252581 3.766990291262136 14.5752427184466 0.4111751310040221 0.5391262081434103 1.9531099596461143 1.4352255968673668 0.8293137150283321 0.3006328742463684 0.1868885334554594 0.0636449972198752 0.0187924599370755 0.1473962800256471 +Oculomotor apraxia 3 22 2.126942701018776 0.0334248443370694 5.648058252427185 24.56553398058253 0.4636956319177163 0.5717143314512599 2.6876056974482267 2.699887889853458 0.7708144058365661 0.3119126109104529 0.0584635742500571 0.0077976080130679 0.1315761252418354 0.1956233162754421 +Sepsis 4 13 2.1143334451251103 0.034486797729144 3.8567961165048543 18.944174757281555 0.35575678916449 0.5917235453265804 2.566849420734061 2.7162384842720413 0.8248844983225841 0.3143879015041122 0.0348230103466341 0.1170412325774002 0.0153040129106345 0.1681830958171223 +Somatic sensory dysfunction 8 82 2.107504180515237 0.0350738997013515 20.62621359223301 103.13106796116504 0.4616647154578088 0.6224901145055866 6.697057188310742 11.252715134072538 0.8145956960114787 0.3487626343279149 0.0094668113768523 0.0155281564103708 0.03006342182992 0.0364413059574398 +Abnormal cornea morphology 20 116 2.1043585378296705 0.035347183310852 30.74271844660194 150.09223300970874 0.1968515799266131 0.7105111239891984 9.65581571261939 17.92341414533844 0.729552037792794 0.3226298921023764 0.0913468899063088 0.0219071828436092 0.0172025623923765 0.2212830190961307 +Thoracic kyphosis 4 13 2.0809543955232126 0.0374380805028256 3.849514563106796 15.725728155339803 0.7266071624304212 0.4267138621860136 1.957478752201897 1.77496566461622 0.8648337345468261 0.3040731381323691 1.0 0.0483495219963649 0.0016938518124182 0.0294030506330725 +Functional abnormality of male internal genitalia 8 25 2.0753868935647244 0.0379506919117704 6.992718446601942 28.27912621359223 0.017260631210362 0.6900146770012617 3.6619859576106233 3.758130501667721 0.6557039240630187 0.2782668768845158 1.0 0.71050391248131 0.0034910212429255 0.1574131928175915 +Coarse hair 5 14 2.074240872564039 0.0380569460468924 4.686893203883495 18.616504854368937 0.2343700701412837 0.5417146669091575 2.329949176130645 1.927954652781107 0.8671729178541636 0.2932988727143946 0.1828652209005429 0.0609936469852355 0.0173259681631819 0.0138285747900004 +Abnormality of the biliary system 9 90 2.0732740078163667 0.0381467862376059 24.728155339805824 113.4878640776699 0.4226772043353868 0.5416117734931738 8.513489210598458 10.938368752781027 1.0946055307638114 0.3805906621326833 0.038091383352994 0.0009986848430443 0.0541074903026873 0.0856623858352892 +Severe muscular hypotonia 4 18 2.0692537950865955 0.0385222770061017 7.621359223300971 29.08252427184466 0.4891205928109223 0.6102633656375805 3.107668263506767 4.151030453059386 0.6943996582599059 0.3174497499656805 0.3651094145888684 0.5978216913417371 0.0743165580351533 0.0799669228120942 +Nephrotic syndrome 8 21 2.058560115239556 0.0395363968806856 6.691747572815534 26.449029126213592 0.5692557086068671 0.4287880468715059 3.1782986616871702 3.4415823902191023 1.075640445131052 0.3251004953320756 0.0832345551470191 0.24979326873168 0.0100095940368711 0.0496450716031089 +Corpus callosum atrophy 0 12 2.0541030833109497 0.0399657157093058 3.8907766990291264 14.728155339805824 0.1983845931768132 0.4648037373286657 2.580775148596329 1.1570314775092398 1.0666401582531118 0.3051438618178521 0.0937235599037543 0.179062604831997 0.3904027877902372 0.6330296848923271 +Abnormal cerebral vascular morphology 4 56 2.0532690936144893 0.0400464865900345 15.009708737864075 66.96116504854369 -0.3384936427640131 0.605840096434048 7.41062625346633 6.201193637208649 0.7978561334780985 0.3159926805324345 0.0881349697343571 0.1603211314581606 0.4288767817294824 0.4815627693528874 +Epiphyseal stippling 3 10 2.050994366250747 0.0402674953868431 4.638349514563107 12.094660194174756 1.0555865796987824 0.32401635996293 2.3050778042540805 1.737163917644219 0.9677864882437331 0.2966156619887163 0.1330370821365251 0.0001713818070774 0.0051006501172469 0.0122308814288206 +Nephropathy 1 18 2.049045357928424 0.0404576798398081 4.953883495145631 20.679611650485437 0.6460031144846833 0.4125859609731191 2.359716427347698 2.5216098734814283 1.0719980152629416 0.3150102108345451 0.0402962873689797 0.1333872493386999 0.4739336636289568 0.6217865623771756 +Abnormal conjunctiva morphology 6 23 2.043631281094032 0.0409899866017213 6.997572815533981 26.58495145631068 0.5265054436970301 0.4429378103171669 2.669041123051977 2.4927208099742058 1.133049116684961 0.3300379664677785 0.0111951113174208 0.0023682370591 0.0084996601315941 0.1817756231984125 +Mucosal telangiectasiae 2 7 2.038909363270832 0.0414590742525651 3.2354368932038833 9.689320388349516 0.8501086222195428 0.291727970426265 1.410916714116348 1.5996305775803197 1.2598794700933909 0.2907637890882055 0.0082126449787597 0.002509898486982 0.0300655360870906 0.1546162324240269 +Cholestasis 6 58 2.0362382779644825 0.0417264342880685 15.12864077669903 73.12621359223301 -0.1533338488158703 0.6363416250341963 6.110269494723051 7.831886047509531 0.802310534936049 0.318351098358666 0.0497406574018307 0.0013336025266624 0.0552153964222827 0.1238607082008744 +Frontotemporal dementia 4 10 2.031781095210678 0.0421758218658292 3.4344660194174756 10.344660194174756 0.5931524822816645 0.4529040772840182 1.8896952177098856 1.3751065734754873 0.9402199282689112 0.308701646569884 0.1201219647894398 0.0265618978442646 0.1318172807011351 0.0076388583027653 +Jaundice 4 43 2.024315603751023 0.0429376891444346 11.669902912621358 55.04854368932039 -0.1632943358508809 0.6130043670700572 5.016745453182805 6.711283992695847 0.8080539802426987 0.3161815409710927 0.0251810229681786 0.0086698838229173 0.0959728569020479 0.1791660447694253 +Ascites 8 24 2.0156402990630404 0.0438376025758664 6.538834951456311 25.800970873786408 0.2860997134153194 0.2561597752608451 2.6559964399945706 3.331112387328855 1.6846905274497244 0.2824645045304154 0.0003904324769383 2.626099802880824e-08 5.314782051766234e-05 0.000148196785101 +Progressive neurologic deterioration 3 18 2.0150686285465267 0.0438974587559966 6.75 20.466019417475728 0.5813429756502071 0.2930928839947513 2.6727908035631316 1.300228015706032 1.5791549964390388 0.3142214461904322 0.0187248462666395 0.0008016777344491 0.0203336527808929 0.0172802721197194 +Diabetes insipidus 3 12 2.0142403345586124 0.0439843068497749 3.342233009708738 12.810679611650484 -0.0213197787173667 0.6545486721148438 2.252692642124361 1.6570187653172312 0.7233830752279996 0.2830553120317765 0.1706778675257841 0.3128615540599918 0.0133642522995781 0.1126513905607482 +Psychomotor deterioration 3 8 2.0093349581431297 0.0445016229219259 3.2645631067961167 8.910194174757281 0.9753014938956188 0.1960965459818884 1.3866235282600423 0.7031088807706056 1.4929387846379636 0.2609606457365817 0.0017760204843955 0.0069232563631819 0.0002086676392486 0.0028246814840344 +Blindness 5 66 2.0064015376988804 0.044813424398431 17.50485436893204 77.9878640776699 0.5531690923808372 0.4517712920686044 6.330499123572238 7.312865926515748 1.2869313794328858 0.374312554297374 0.0003984546477083 0.0134142100600963 0.0551918016716766 0.0628473887263958 +Hepatosplenomegaly 10 31 2.0034408059546576 0.0451299952339114 8.516990291262136 37.93689320388349 -0.2491143078233153 0.3795771447816016 3.305218390901912 4.60907695182212 1.4437156893960243 0.3360994118928947 0.0010840000082347 3.3084941313325093e-06 1.5377372660172105e-05 0.0054852212395234 +Abnormality of the tongue 11 68 1.989827921985234 0.0466098944826081 22.424757281553397 89.52912621359224 0.5421010507218363 0.5607339999720974 6.938472222740965 9.436122816051313 0.9593463898963266 0.3606735981467843 0.0432872408847351 0.0500901737403142 0.0156258582246428 0.1144286024497217 +Abnormality of glycolipid metabolism 3 6 1.98902114545122 0.0466988690403051 3.83495145631068 7.228155339805825 0.3163887308740252 0.1681411938672545 1.311614193945771 0.5964160722258837 1.870431483654663 0.2292796295173983 1.0515666421094113e-07 1.7486004913858212e-06 6.494328716879693e-05 5.5966724052351854e-05 +Postural instability 2 15 1.9696971069565865 0.0488730947568853 3.533980582524272 17.79126213592233 0.4509430795614677 0.5268149729159746 2.1579185133601717 2.125919871541916 0.8315457301240203 0.299833681390129 0.2486824788491954 0.1106573079891401 0.1682806103596247 0.1522313234140426 +Urinary glycosaminoglycan excretion 4 5 1.9660084521602823 0.049297634282126 2.9490291262135924 6.563106796116505 0.4749855796693131 0.2196485727407601 1.2846457065606351 0.9261036754709504 1.6390629541794843 0.2603486997442626 0.0023758658868836 1.094486762177302e-05 2.050947898007762e-05 0.000543833852376 +Infantile muscular hypotonia 4 49 1.9647933220835463 0.049438163427693 13.900485436893204 66.00242718446601 0.112520259201691 0.5910142955974006 6.420333276084778 7.344999879849499 0.9387709887425064 0.3382916955300774 0.0065722437922867 0.0171603994289533 0.0809926544896275 0.3318417232353198 +Abnormal pharynx morphology 8 31 1.963643545026068 0.0495714438193388 8.514563106796116 37.03398058252427 0.1877670148504528 0.5274660382080113 3.853164322289049 5.032786743682863 1.0570894568249165 0.3376598170825433 0.1043267655807623 0.0048126691185456 0.0016484450413724 0.0966482219899011 diff --git a/msigdb_hp/metrics.json b/msigdb_hp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..69621b7f73febee3f35883d72e2019063ebc135e --- /dev/null +++ b/msigdb_hp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2453, + "annotations_size": 4423, + "title": "Average number of proteins per term", + "value": 19.19059461903685 +} \ No newline at end of file diff --git a/msigdb_hp/paths.json b/msigdb_hp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..42ff4a24469c404399c5121742f2980d42b6bdc7 --- /dev/null +++ b/msigdb_hp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_hp/fragment/C334/C334_val_log2fc"} \ No newline at end of file diff --git a/msigdb_hp/result.tsv b/msigdb_hp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..35b7a4750218f8d3babfc0df9e82d95e94c5b6b0 --- /dev/null +++ b/msigdb_hp/result.tsv @@ -0,0 +1,1219 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Mental deterioration 0.6723349170759478 3.653872725998085 0.0002583143497045 0.6810343809824354 0.0081608883481668 81 Q13501,P05067,P06865,Q9BQE5,O75503,P07686,P61916,O15118,P17900,P04062,P50897,P54802,Q8NC96,O43464,Q14108,P16278,Q13510 17 +Cognitive impairment 0.5765489793486418 3.4823992111624147 0.0004969422498102 0.8890329407661564 0.012210975393948 135 P05067,O75503,P06280,P61916,P17900,Q8NC96,P50897,Q14108,Q9Y263,P16278,P06865,P07686,O15118,P54802,Q13510,Q13501,P04062,Q9BQE5,O43464,O95831 20 +Abnormal systemic arterial morphology 0.5508916313420542 3.281418792361017 0.0010328626173146 0.9896494148208944 0.0194096792351008 116 P05067,P06865,Q99519,Q9UBM7,Q15056,P07686,P10619,P61916,O15118,Q9NWM8,P10253,P17900,P04062,P38571,P16278,Q13510 16 +Abnormality of the spleen 0.5633048337085469 3.0628722163833837 0.0021922365032933 0.9999391382623648 0.0323575195676775 99 Q99519,Q15904,P07686,P10619,P61916,O15118,P10253,Q15392,P04062,P54802,P08236,P38571,Q14108,Q13510,P16278,P15586 16 +Corneal opacity 0.70534659999168 3.057395777800691 0.0022326926801261 0.9999491301579349 0.0328079725056412 41 Q99519,Q9UBM7,P06280,P10619,P04062,O43505,P08236,P16278,Q13510 9 +Dementia 0.6825536472320275 3.056166137905018 0.00224186996044 0.999951158120761 0.0328337444868424 50 Q13501,P05067,P06865,P61916,O15118,P17900,P04062,Q14108,Q13510 9 +Abnormality of the vasculature of the eye 0.6239826717606817 2.9745297946778795 0.0029343795768947 0.999997734784155 0.0401773541242222 64 P06865,Q99519,P06280,P07686,P10619,P02786,P17900,Q14739,P16278,Q13510 10 +Abnormality of head blood vessel 0.8372751264278 2.973616173703194 0.002943129716538 0.9999978210260256 0.0401773541242222 21 P06865,Q99519,P07686,P10619,P17900,P16278,Q13510 7 +Abnormal retinal artery morphology 0.8540865536510032 2.9188647042346743 0.0035130866189614 0.9999998262659316 0.0465221021427138 19 P06865,Q99519,P07686,P10619,P17900,P16278,Q13510 7 +Abnormal retinal vascular morphology 0.6771039881368959 2.9144790601386936 0.0035628270950347 0.9999998606843056 0.0467607840989278 44 P06865,Q99519,P07686,P10619,P17900,P16278,Q13510 7 +Splenomegaly 0.5709187162940489 2.744244339613348 0.0060650376207429 0.999999999997938 0.0732941568211641 77 Q99519,Q15904,P61916,O15118,P10253,Q15392,P04062,P54802,P08236,P38571,Q14108,Q13510,P16278,P15586 14 +Coarse facial features 0.6218761178531894 2.724941179629417 0.0064312943480375 0.999999999999596 0.0750523484355346 55 Q96AX1,Q99519,P06280,Q15056,P07686,P10619,O95831,P54802,P08236,O00170,Q9Y263,P16278,P15586 13 +Dysphagia 0.521315699095474 2.694268168941642 0.0070543382012846 0.9999999999999748 0.0802929704219383 101 Q13501,P05067,Q99519,P55011,Q9UHX1,P67870,P61916,P01889,O15118,Q9BUF5,P04062,Q01105,Q9Y263,Q14108,Q13510,Q14739,P15586 17 +Increased bone mineral density 0.7571206235406738 2.68813659535787 0.0071851997643039 0.999999999999986 0.0802929704219383 23 Q13501,Q15056,Q15392,P04062,P54802,Q14108,Q14739 7 +Loss of speech 0.8475723869467373 2.6828204568389884 0.0073004171876867 0.9999999999999916 0.0807243630528457 16 P17900,P50897,P61916,O15118 4 +Angiokeratoma 0.988168094655243 2.673640075632873 0.0075032933293452 0.9999999999999966 0.0825463431879421 2 P06280 1 +Vacuolated lymphocytes 0.9865361077111382 2.6669830523776934 0.0076535531221284 0.9999999999999982 0.0835843591584547 2 P16278 1 +Cherry red spot of the macula 0.9538955606914676 2.655346396774069 0.0079227006005753 0.9999999999999994 0.0863106028481394 9 P06865,Q99519,P07686,P10619,P17900,P16278 6 +Intracellular accumulation of autofluorescent lipopigment storage material 0.9816401468788256 2.646983164602366 0.0081213396040198 0.9999999999999998 0.0880408947759307 2 O75503 1 +Abnormal vascular physiology 0.666558719701046 2.639161047826445 0.0083111487955691 1.0 0.0894409029751883 37 P05067,Q96AX1,P06280,Q15056,P01889,Q9NWM8,P04062,Q14108,Q14739 9 +Myoclonus 0.574646923594495 2.6380172017389976 0.0083392351629385 1.0 0.0895253328293136 66 P05067,Q99519,O75503,P67870,O14773,P04062,P50897,Q01105,Q14108,Q13510 10 +Asymmetric septal hypertrophy 0.9791921664626684 2.636967003121631 0.0083650968138213 1.0 0.0895855283475348 2 P15586 1 +Arteriosclerosis 0.8617901714582283 2.595032850229382 0.0094581878651021 1.0 0.0986640682248741 14 Q99519,P61916,O15118,P38571,P16278 5 +Abnormal exteroceptive sensation 0.6322814091956542 2.582310895636743 0.0098141130482498 1.0 0.1021360517939038 42 P05067,P06280,P07686,O95831,P01889,P54802,Q8NCH0,O00170,O15269,O15460 10 +Abnormality of the lymphatic system 0.488851605248195 2.574731837208823 0.0100317830585161 1.0 0.1040593742108018 122 Q99519,Q15904,P07686,P10619,P61916,O15118,P10253,Q15392,P04062,P54802,P08236,P38571,Q14108,Q13510,P16278,P15586 16 +Cerebral inclusion bodies 0.885185053074945 2.560833711769804 0.010442132349173 1.0 0.1071590519266641 12 P05067,P61916,O15118 3 +Hallucinations 0.6574434872956604 2.536889270948778 0.0111842323152011 1.0 0.1136547714256016 36 Q13501,P05067,Q9BQE5,O75503,P04062,P50897 6 +Diarrhea 0.597652344375079 2.522480318675005 0.0116530470890421 1.0 0.1158504325967923 54 Q15904,P06280,P07686,P02786,P01889,Q13423,P42892,P54802,O43464,Q7Z2Z2,P38571,Q13510,P15586 13 +Prominent sternum 0.950224398204816 2.5176206784132673 0.0118150487112385 1.0 0.1166472331468926 2 P16278 1 +Metaphyseal cupping 0.9502243982048147 2.5176206784132673 0.0118150487112385 1.0 0.1166472331468926 2 Q14739 1 +Abnormal urine carbohydrate level 0.9172242296875178 2.5152674444120744 0.0118942118168825 1.0 0.11699688397658 9 P10253,P16278 2 +Fractures of the long bones 0.9477764177886586 2.5074656294569326 0.0121600407085615 1.0 0.1192546786119021 2 Q13501 1 +Abnormality of corneal stroma 0.8922359729243071 2.472686824439001 0.0134101600937617 1.0 0.1264672454044949 10 P10619,Q13510,P16278,O43505 4 +Abnormal tissue metabolite concentration 0.8813204539956594 2.4294533378344196 0.015121611283424 1.0 0.1387611757398019 10 P06280,P06865,P07686,P17900 4 +Hyperintensity of cerebral white matter on mri 0.8222280057648899 2.4245196509660754 0.0153286537068102 1.0 0.1397910007117974 14 P10253,O75503 2 +Abnormal protein o linked glycosylation 0.9273765809873544 2.422420260872333 0.01541750893348 1.0 0.1399592244035633 2 Q15904 1 +Juvenile onset 0.6194741482228097 2.421842759736786 0.0154420306373364 1.0 0.1399592244035633 39 P06280,O14773,O15118,P54802,P38571,P16278 6 +Abnormal circulating cholesterol concentration 0.6950670900808912 2.4148498036634773 0.0157416994188968 1.0 0.1423835102858498 24 Q15904,Q9UBM7,P61916,Q15392,P38571,Q14739 6 +Progressive visual loss 0.7477812779331493 2.409685422936097 0.0159662805348153 1.0 0.1441018317874275 19 Q99519,P50897,O75503 3 +Hydrops fetalis 0.6431371856214468 2.4052093378785004 0.0161632040249766 1.0 0.1441868118734533 35 Q99519,P10619,P04062,P08236,P16278,Q13510 6 +Abnormality of extrapyramidal motor function 0.5618425350793068 2.3966683746581148 0.0165448901096543 1.0 0.1461728300854852 61 Q13501,P05067,P06865,Q15056,P07686,P17900,P04062,O43464,P16278 9 +Developmental regression 0.4915083802333524 2.3843190507361185 0.0171107605266227 1.0 0.1507587526080725 101 Q99519,O75503,P06280,Q15056,P07686,O14773,P17900,O95831,P16278,Q13510 10 +Cirrhosis 0.6553259857417848 2.376670343245371 0.0174696930734274 1.0 0.152353434837312 32 Q15904,P04062,P38571,P11717,Q14108 5 +Ectopic calcification 0.593562239771378 2.3736807999918095 0.017611768313152 1.0 0.152353434837312 47 P05067,Q99519,O00584,Q9UBM7,P04062,P08236,P38571 7 +Limb ataxia 0.7396815611174623 2.3695295307792583 0.0178107326980854 1.0 0.152353434837312 19 Q14108,Q13501,Q8IV08,O14773 4 +Left ventricular hypertrophy 0.713841963573821 2.3544919388945997 0.0185480459996796 1.0 0.1556698433711252 21 P06280,P10253,Q07021 3 +Abnormal arterial physiology 0.6763192655687422 2.3469567503486104 0.0189274516749391 1.0 0.1585532552239693 26 P05067,O75844,P06280,Q15056,P01889,Q9NWM8,O15460,Q14739 8 +Abnormality of the autonomic nervous system 0.6074973595289958 2.33997340067298 0.0192851133405265 1.0 0.1612439627696574 39 Q9UBM7,P06280,P07686,Q96EK5,P04062,P42892,O15269 7 +Paresthesia 0.7087591353525353 2.327952464097212 0.0199146279509512 1.0 0.1637219320205525 21 P05067,P06280,P01889,P54802,O00170 5 +Hepatomegaly 0.472915986313137 2.318060608335945 0.0204460273672106 1.0 0.1671585564605782 138 Q99519,O43772,Q15904,P07686,P61916,O15118,P10253,P04062,P54802,Q14739,P08236,P38571,Q14108,Q13510,P16278,P15586 16 +Stroke 0.6704171174118793 2.2945314084523303 0.0217599930857588 1.0 0.1729548805086447 25 P06280,P05067 2 +Glossitis 0.8967768257853949 2.2934549285735013 0.0218218273810117 1.0 0.1729548805086447 2 P01889 1 +Gastrointestinal infarctions 0.8967768257853949 2.2934549285735013 0.0218218273810117 1.0 0.1729548805086447 2 P01889 1 +Recurrent pharyngitis 0.8967768257853949 2.2934549285735013 0.0218218273810117 1.0 0.1729548805086447 2 P01889 1 +Abnormal circulating lipid concentration 0.5398044647557562 2.264755129724123 0.0235277103250286 1.0 0.1788025133463947 63 O43772,Q15904,Q9UBM7,P06280,P61916,Q15392,P38571,Q14739 8 +Cardiomegaly 0.6355996983207927 2.254815091328168 0.0241449376198339 1.0 0.1806989155541887 32 Q99519,Q07021,P07686,P10253,P04062,P54802,Q14739 7 +Chronic diarrhea 0.8061159124527487 2.2317375844784686 0.0256323116526964 1.0 0.1905406965376071 12 P07686,Q15904,P02786 3 +Abnormality of the peripheral nervous system 0.5133451569298005 2.219686921686353 0.0264400272351896 1.0 0.1934663462052561 76 Q99519,Q9UBM7,P06280,P07686,Q96EK5,P42892,P04062,O43464,Q9ULM3,O95831,O15269,P38398 12 +Prolonged neonatal jaundice 0.7877039711688543 2.210597712837592 0.027063707287857 1.0 0.1962340612035926 13 P61916,Q15904 2 +Exaggerated startle response 0.8902447776092778 2.207923747401833 0.0272495891176738 1.0 0.1968290967425653 8 P06865,P07686,P17900,P16278 4 +Abnormal male reproductive system physiology 0.6280129461306202 2.2074981561346796 0.0272792756733422 1.0 0.1968290967425653 32 P38398,Q9BZH6,Q15056,P07686,P51809,Q13423,P04062,P54132,O43464,O00170,Q658P3 11 +Abnormal autonomic nervous system physiology 0.6538502747180547 2.2001747962668365 0.0277944957584994 1.0 0.1973227883709633 25 P06280,P04062,P07686,P42892 4 +Tissue ischemia 0.7055878531343731 2.198325694567541 0.0279259046281827 1.0 0.1973227883709633 19 P06280,P05067,P01889,Q15056 4 +Oligosacchariduria 0.986938775510204 2.1981396996768408 0.0279391522011254 1.0 0.1973227883709633 3 P10253,P16278 2 +Ventricular hypertrophy 0.6259685776174482 2.1947048969220733 0.028184773239039 1.0 0.1978750032321738 32 P06280,P10253,O43772,Q07021 4 +Dysarthria 0.4579791478972355 2.192735678215683 0.0283264285983764 1.0 0.198554348162629 127 Q13501,O75503,P07686,Q8IV08,P61916,O14773,O15118,P04062,Q14108,P15586 10 +Sea blue histiocytosis 0.9816326530612244 2.1783613971220723 0.0293791414807174 1.0 0.204314375423291 3 P61916,P16278 2 +Thickened ribs 0.9795918367346936 2.170744228687721 0.0299505118754304 1.0 0.2069406907325827 3 P16278,P15586 2 +Dysmetria 0.5707858627249827 2.169518877397894 0.0300433127672383 1.0 0.2069461644967148 44 Q13501,Q99519,O75503,Q8IV08,O14773 5 +Dysgraphia 0.7641948699333657 2.1676730747206174 0.0301835694842809 1.0 0.207301130169215 14 Q13501,P05067 2 +Macroglossia 0.641271032912275 2.164009154669258 0.0304636468161507 1.0 0.2078213395912904 27 Q15056,P07686,P10253,O00170,P16278 5 +Short stepped shuffling gait 0.8653610771113872 2.159337170805334 0.0308240183822303 1.0 0.2084545419503825 2 P04062 1 +Abnormal vascular morphology 0.4683477899404548 2.1553570793858916 0.0311339023152961 1.0 0.2086186986155674 180 P05067,Q9UHX1,P61916,P10253,P17900,P42892,P16278,P06865,Q99519,P07686,P10619,Q9Y487,O15118,P38571,Q13510,P55011,Q96AX1,Q9UBM7,P01889,Q15392,P04062,P08236,Q15056,Q9NWM8 24 +Abnormal cerebral artery morphology 0.7878049076349071 2.1535838649887964 0.0312728207331367 1.0 0.2086186986155674 12 P05067 1 +Bone marrow foam cells 0.977950183748468 2.1517008067259 0.0314209265712968 1.0 0.2086186986155674 4 Q99519,P61916,O15118 3 +Generalized osteosclerosis 0.8633210934312568 2.1505694991415107 0.0315101949224554 1.0 0.2086186986155674 2 Q15392 1 +Dysostosis multiplex 0.9256066290620218 2.144578269902737 0.0319865812512141 1.0 0.2092849835415977 7 Q99519,P10619,P54802,P16278,P15586 5 +Abnormal vertebral morphology 0.4942669410064798 2.1430653453696764 0.0321078516620449 1.0 0.209476848306181 86 Q99519,Q9UBM7,Q15056,P10619,O95831,P04062,P54802,Q14739,P08236,Q14108,Q8NCH0,P16278,P15586 13 +Telangiectasia 0.6339032401290164 2.1410797765744225 0.0322676052427446 1.0 0.2098817911597934 28 P06280,Q99519,P10619,Q14739 4 +Abnormal lactate dehydrogenase level 0.7440305855461473 2.140049978862546 0.0323507279131571 1.0 0.2101134648456596 15 P10253,O43505 2 +Macular degeneration 0.7844686114823336 2.139265208979685 0.0324141956668793 1.0 0.2102169903733243 12 P50897,Q13510 2 +Abnormal sarcomere morphology 0.8600571195430482 2.136526577159255 0.0326365170657232 1.0 0.2108844606300977 2 Q13501 1 +Abnormal z disc morphology 0.8600571195430482 2.136526577159255 0.0326365170657232 1.0 0.2108844606300977 2 Q13501 1 +Abnormal macrophage morphology 0.9762975071516148 2.135651482396387 0.032707831786626 1.0 0.2108844606300977 6 Q99519,P61916,O15118,P38571,P16278 5 +Foam cells 0.9762975071516148 2.135651482396387 0.032707831786626 1.0 0.2108844606300977 6 Q99519,P61916,O15118,P38571,P16278 5 +Undetectable electroretinogram 0.9698227795747002 2.1342046154587844 0.0328260350644347 1.0 0.2113385052256109 3 P50897 1 +Decreased palmar creases 0.8588331293349691 2.1312558499583334 0.0330680701500583 1.0 0.2125873172582963 2 Q8NCH0 1 +Abnormal endocardium morphology 0.7691144188538542 2.129104249720804 0.033245636252581 1.0 0.2134186489770187 13 P06280,Q15056,P04062 3 +Oculomotor apraxia 0.662214450978843 2.1269427010187756 0.0334248443370694 1.0 0.2139480267769296 22 Q13501,P05067,O14773 3 +Sepsis 0.7657641999515015 2.1143334451251103 0.034486797729144 1.0 0.2185316709971408 13 Q96AX1,P42892,P01889,P02786 4 +Somatic sensory dysfunction 0.4954387004068277 2.107504180515237 0.0350738997013515 1.0 0.2206712067981193 82 P05067,P06280,P07686,Q8IV08,O14773,P54802,O95831,O15269 8 +Abnormal cornea morphology 0.4452617993243954 2.1043585378296705 0.035347183310852 1.0 0.2220747042384925 116 P06280,O43505,P16278,Q99519,P10619,Q10471,Q13510,P55011,Q9UBM7,P01889,P04062,P08236,P38398,Q14739,Q07021,Q15056,Q96EK5,Q9NWM8,Q7Z6Z7,Q8NCH0 20 +Diastasis recti 0.8510811913504732 2.0978163198338136 0.0359213743001758 1.0 0.2239116551509956 2 Q8NCH0 1 +Thoracic kyphosis 0.7582146566979187 2.0809543955232126 0.0374380805028256 1.0 0.2280835124848452 13 P08236,O95831,P04062,Q9UHX1 4 +Functional abnormality of male internal genitalia 0.6322155963948732 2.0753868935647244 0.0379506919117704 1.0 0.2305713053925285 25 P38398,Q15056,P51809,Q13423,P04062,P54132,O00170,Q658P3 8 +Coarse hair 0.7435248351347991 2.074240872564039 0.0380569460468924 1.0 0.2308996877440403 14 Q96AX1,Q9Y487,Q9UM00,P54802,P15586 5 +Abnormality of the biliary system 0.4816301645823192 2.0732740078163667 0.0381467862376059 1.0 0.2311277199026452 90 Q15904,Q9UBM7,P61916,O15118,P04062,P38571,Q14108,Q14739,Q13510 9 +Severe muscular hypotonia 0.6922508042566234 2.0692537950865955 0.0385222770061017 1.0 0.232146010531507 18 Q01105,P67870,O43505,Q9NWM8 4 +Nephrotic syndrome 0.6580614432296495 2.058560115239556 0.0395363968806856 1.0 0.2359912056724327 21 Q96AX1,Q07021,P06280,O95721,Q9NQW6,P51809,Q14108,Q8NCH0 8 +Cataplexy 0.9483360906428256 2.0533923724242076 0.0400345384737164 1.0 0.2380720567039282 3 P61916 1 +Abnormal cerebral vascular morphology 0.5326180778477284 2.0532690936144893 0.0400464865900345 1.0 0.2380720567039282 56 P06280,P05067,P04062,P10253 4 +Epiphyseal stippling 0.7882065408377572 2.050994366250747 0.0402674953868431 1.0 0.2382747242762604 10 P08236,Q99519,Q9UBM7 3 +Nephropathy 0.6882328441025081 2.049045357928424 0.0404576798398081 1.0 0.2382747242762604 18 P06280 1 +Abnormal conjunctiva morphology 0.6383738479726756 2.043631281094032 0.0409899866017213 1.0 0.2388652315407294 23 Q96AX1,P06280,P10619,P02786,Q14739,Q13510 6 +Mucosal telangiectasiae 0.8970787166246611 2.038909363270832 0.0414590742525651 1.0 0.2407184814960113 7 P06280,P10619 2 +Cholestasis 0.525809233630954 2.0362382779644825 0.0417264342880685 1.0 0.2407184814960113 58 Q15904,Q9UBM7,P61916,O15118,P38571,Q13510 6 +Neurofibrillary tangles 0.9453772729854482 2.031781688556356 0.0421757617713489 1.0 0.2407184814960113 4 P05067,P61916 2 +Frontotemporal dementia 0.7835900665750573 2.031781095210678 0.0421758218658292 1.0 0.2407184814960113 10 Q13501,P05067,O96008,P35637 4 +Jaundice 0.5524133328301772 2.024315603751023 0.0429376891444346 1.0 0.2407184814960113 43 P38571,Q15904,P61916,O15118 4 +Ascites 0.6244257323236763 2.0156402990630404 0.0438376025758664 1.0 0.2431782364956932 24 Q99519,P61916,O15118,P04062,P08236,P38571,Q14108,Q13510 8 +Progressive neurologic deterioration 0.6814981442019838 2.0150686285465267 0.0438974587559966 1.0 0.2431782364956932 18 P07686,P54802,P16278 3 +Increased cerebral lipofuscin 0.9407814935376096 2.0147510407628433 0.0439307412683163 1.0 0.2431782364956932 4 P50897,O75503 2 +Diabetes insipidus 0.7555734357879671 2.0142403345586124 0.0439843068497749 1.0 0.2431782364956932 12 P06280,Q9BZH6,P01889 3 +Recurrent tonsillitis 0.8310893512851945 2.0111217938029924 0.0443125937150616 1.0 0.2442067967539435 2 P54132 1 +Psychomotor deterioration 0.8388887693701037 2.0093349581431297 0.0445016229219259 1.0 0.2442067967539435 8 P06865,P50897,Q9Y487 3 +Blindness 0.5007842605274809 2.0064015376988804 0.044813424398431 1.0 0.2456131054699635 66 P06865,P17900,P50897,O43505,P16278 5 +Hepatosplenomegaly 0.599945610755284 2.0034408059546576 0.0451299952339114 1.0 0.2467366735718053 31 Q96AX1,Q99519,P07686,P10619,P04062,Q14739,P38571,Q13510,P16278,Q658P3 10 +Esophageal varix 0.9334741064010912 1.997146390708234 0.0458092827051452 1.0 0.2483020311334039 3 P38571 1 +Ileus 0.8274173806609578 1.995128560621527 0.0460288600944687 1.0 0.2489270977480261 2 Q01844 1 +Branchial cyst 0.8266013871889075 1.9915716294753687 0.0464180787680632 1.0 0.249765404368788 2 Q9UHX1 1 +Abnormality of the tongue 0.492887835151663 1.989827921985234 0.0466098944826081 1.0 0.2503625427457816 68 Q96AX1,Q99519,Q9UBM7,Q15056,P07686,P67870,O95831,P10253,O00170,P16278,Q13510 11 +Abnormality of glycolipid metabolism 0.9350693992186772 1.9890211454512197 0.0466988690403051 1.0 0.2503625427457816 6 P06280,P06865,P17900 3 +Postural instability 0.7075794103740017 1.9696971069565865 0.0488730947568853 1.0 0.2588810755804839 15 P04062,O75503 2 +Urinary glycosaminoglycan excretion 0.9227941176470588 1.9660084521602823 0.049297634282126 1.0 0.2608175076912005 5 P08236,P54802,P16278,P15586 4 +Infantile muscular hypotonia 0.5353948998070275 1.9647933220835463 0.049438163427693 1.0 0.2612485027965188 49 P10253,P17900,Q99519,P16278 4 +Abnormal pharynx morphology 0.593648850680652 1.963643545026068 0.0495714438193388 1.0 0.2616402100393029 31 P01889,P54802,P54132,Q03519,P08236,P15586,P16278,Q13510 8 +Agitation 0.5916204207118255 1.950787801972078 0.0510822934855657 1.0 0.2679475650674484 31 P35637,P05067,Q13501,Q92804,P42892,O96008,P04062,O43464,Q15165 9 +Ovoid vertebral bodies 0.9243085680463275 1.9503875504074373 0.0511299445889501 1.0 0.2679475650674484 6 P16278,P15586 2 +Heparan sulfate excretion in urine 0.9224173131890542 1.946432492004736 0.051602809766716 1.0 0.2694678011784948 4 P08236,P54802,P15586 3 +Diminished motivation 0.6198112631169923 1.938351915390082 0.0525803026067519 1.0 0.2732517401907174 23 Q13501,P06865,P17900,P04062 4 +Abnormality of femur morphology 0.5343910410622941 1.932202028492742 0.0533345749226632 1.0 0.2755827393492284 47 P55011,Q9UHX1,P06280,Q9Y487,P04062,Q7Z2Z2,O95831,P16278,Q14739 9 +Visual loss 0.541007342359486 1.9225811763580372 0.0545326698842139 1.0 0.2801370486618793 41 Q99519,P50897,O75503 3 +Pedal edema 0.9101802675735994 1.9195701739004247 0.0549122144920466 1.0 0.2810495389418214 5 Q14108,P04062 2 +Aspiration 0.8651306192117558 1.9191569801857704 0.0549644700847107 1.0 0.2810495389418214 7 P17900 1 +Abnormal morphology of the conjunctival vasculature 0.9094547859416356 1.916893243358298 0.0552514956372198 1.0 0.2818654731296695 5 P06280 1 +Clumsiness 0.6720825309014115 1.9128226170025255 0.0557707647156944 1.0 0.283207913131477 17 Q13510,O14773,O75503 3 +Long penis 0.8078335373317063 1.9094798438526048 0.0562002194719724 1.0 0.2842918055398989 2 O00170 1 +Abnormal spermatogenesis 0.7316031534419283 1.9091610936351944 0.0562413135535635 1.0 0.2842918055398989 12 Q658P3,P51809,Q13423,P04062,P54132,P38398 6 +Elevated circulating alanine aminotransferase concentration 0.7652894671775222 1.9076997365832609 0.0564300357980842 1.0 0.2849201465010578 9 P10253,Q15904 2 +Macrogyria 0.91183951456285 1.906891904214686 0.0565345867591449 1.0 0.2851225510099178 4 O43505 1 +Patchy changes of bone mineral density 0.9115842623357558 1.9059360825467424 0.0566584989214891 1.0 0.2854099568642899 4 Q13501,Q14739 2 +Spontaneous recurrent epistaxis 0.8053855569155512 1.8987332792271436 0.0575995536225106 1.0 0.2875426926324658 2 P04062 1 +Giant platelets 0.8053855569155511 1.8987332792271436 0.0575995536225106 1.0 0.2875426926324658 2 Q14739 1 +Abnormal tongue morphology 0.5122190104276679 1.8875317350147376 0.0590888420739676 1.0 0.2929384516206469 56 Q96AX1,Q99519,Q9UBM7,Q15056,P07686,P67870,P10253,O00170,P16278 9 +Abnormal atrioventricular conduction 0.7491473613998789 1.8871211816884368 0.0591440283285638 1.0 0.2929384516206469 10 P06280 1 +Multifactorial inheritance 0.7463557219310486 1.8752963302301149 0.0607519679485704 1.0 0.2969126566149468 10 P10321,P42892,P01889 3 +Azoospermia 0.7338808943086597 1.870146225441121 0.0614635148017628 1.0 0.2987396988661505 11 Q658P3,P51809,Q13423,P04062,P54132,P38398 6 +Gingival overgrowth 0.5992788589083781 1.8690608921751912 0.0616143431483506 1.0 0.2991440611911691 24 Q99519,Q9UBM7,P08236,P16278,Q14739 5 +Unusual infection by anatomical site 0.754688790870258 1.8636873632684616 0.0623656210057523 1.0 0.3017977480398717 9 P01889,P02786,Q14739 3 +Hypoplasia of the odontoid process 0.894474027188714 1.86147214215266 0.0626775311005753 1.0 0.3026448908928438 5 P08236,P16278 2 +Diaphyseal thickening 0.8974030173002947 1.8595017351189025 0.0629560535425266 1.0 0.3036582604346732 3 P08236 1 +Disproportionate short trunk short stature 0.8989616336178465 1.8585729663744084 0.0630876919173282 1.0 0.3038194647810107 4 P16278 1 +Long ear 0.795593635250919 1.8556605951998209 0.0635019507628069 1.0 0.3038194647810107 2 Q7LBC6 1 +Abnormal atrioventricular valve physiology 0.5547452108476126 1.855171331617235 0.0635717641539133 1.0 0.3038194647810107 36 Q96AX1,Q15904,P06280,Q15056,P04062,O00170 6 +Frontal balding 0.793553651570787 1.84667006579218 0.0647949726348826 1.0 0.3072398586232873 2 O60828 1 +Abnormal rib cage morphology 0.5148590083524607 1.8451575307498265 0.0650146263665978 1.0 0.3072398586232873 52 Q96AX1,Q9UBM7,Q9UHX1,P54802,Q03164,Q14739,P08236,O95831,P16278,P15586 10 +Abnormal heart valve morphology 0.5025948579585449 1.8258006499825632 0.0678802953838553 1.0 0.3172208808112272 57 Q14738,Q9UHX1,Q06787,P06280,Q15056,P01889,P04062,P08236,Q8NCH0,P16278,P38398 11 +Flared iliac wing 0.8895728151663712 1.8232241564822211 0.0682694478387853 1.0 0.3184045954634048 4 O95831,P16278 2 +Abnormality of skin adnexa physiology 0.5673343741529185 1.8200682353009097 0.0687486142186153 1.0 0.319406639379134 32 P06280,P07686,Q9H4L7,P01889,O15269,O00170,Q9Y263 7 +Eyelid myoclonus 0.7905484604197367 1.818445536706638 0.0689960638207121 1.0 0.3202199268405138 8 P67870,Q13510 2 +Echolalia 0.7435705908456056 1.8173105476244364 0.0691695758263284 1.0 0.3203797947244847 9 Q13501 1 +Abnormal esophagus physiology 0.4404280913949773 1.81727262402108 0.0691753795979839 1.0 0.3203797947244847 171 P05067,Q9UHX1,P06280,P61916,Q8NC96,P54132,Q14108,Q9Y263,P15586,Q99519,O15118,Q9BUF5,Q13510,Q13501,P55011,Q9UBM7,P01889,P04062,O15269,Q14739,Q15056,P67870,Q01105 23 +Abnormality of the gingiva 0.5323581603836809 1.8092518568107712 0.0704118846371748 1.0 0.324043760075244 39 Q99519,Q9UBM7,Q15392,P04062,P08236,Q14108,P16278,Q14739 8 +Abnormal aortic valve morphology 0.5682531391658797 1.8014597484064208 0.0716304461248584 1.0 0.3283123971090663 31 Q14738,Q9UHX1,P06280,Q15056,P01889,P04062,P38398 7 +Oral pharyngeal dysphagia 0.7392550749886659 1.799250920351246 0.0719789979052971 1.0 0.3291971712085569 9 P67870,Q13510 2 +Abnormal left ventricle morphology 0.5871199291578942 1.7973649730632706 0.0722776976159449 1.0 0.3291971712085569 24 P06280,P10253,Q07021 3 +Dermatological manifestations of systemic disorders 0.5030941673051343 1.7959676462393288 0.0724996627228422 1.0 0.3291971712085569 55 O43772,Q15904,P61916,O15118,P38571 5 +Abnormal metatarsal morphology 0.6575557034036114 1.791266982419414 0.0732504618704679 1.0 0.3291971712085569 16 Q15392,Q9UBM7,O43505 3 +Heterogeneous 0.5541958668801251 1.787956061839835 0.07378309693291 1.0 0.3299723334016797 34 Q14126,P05067,P11717,P61916 4 +Recurrent respiratory infections 0.4447835219954821 1.7855231762024313 0.0741764955111361 1.0 0.3310621994407216 96 Q96AX1,Q15056,Q9Y487,P02786,P01889,P10253,P04062,P54802,P54132,P08236,Q13510,P16278,P15586 13 +Periventricular white matter hyperintensities 0.8778629926545892 1.7820035791801694 0.0747486480655967 1.0 0.3326089239377611 6 O75503 1 +Thoracolumbar kyphosis 0.8726739800207204 1.7803475064471084 0.0750191069243479 1.0 0.3329970179846599 5 P04062 1 +Facial hypotonia 0.7346826920772609 1.7800811667298102 0.0750626782706025 1.0 0.3329970179846599 9 Q14738,P10253 2 +Abnormal myocardium morphology 0.427100904228143 1.7710557812176373 0.0765514262284654 1.0 0.3375742355019966 137 P06280,P10253,Q13423,Q14108,P16278,P15586,Q99519,P54802,O00170,Q96AX1,O43772,Q9H0R6,Q14126,P01889,P04062,P08236,P38398,Q07021,Q15056 19 +Joint subluxation 0.8689965880131705 1.7666094041894438 0.0772936649533224 1.0 0.3398308947202239 5 P16278 1 +Mortality aging 0.4590150774071412 1.7625240506954607 0.0779807965232777 1.0 0.3421716895064061 83 P05067,Q96AX1,Q15904,Q9H0R6,Q9BZH6,Q15056,P07686,P04062,O43464,P38571,P16278,Q14739 12 +Glomerulopathy 0.7303624793906097 1.761935732470872 0.0780801565196931 1.0 0.3422681192136796 9 P06280 1 +Abnormal visual electrophysiology 0.5252005769620638 1.7571856234445802 0.0788861749252403 1.0 0.3454589620736018 39 P50897,O75503 2 +Slowly progressive 0.5114990512460885 1.7560408118684214 0.079081440216735 1.0 0.3456296542278844 47 O00584,Q8IV08,Q14203,O14773,P35251,P50402,Q14331,O95831,O14979 9 +Abnormal ilium morphology 0.6858852675591459 1.7547078175618125 0.0793092981552625 1.0 0.3457562477939973 13 Q96AX1,O95831,P16278 3 +Parkinsonism 0.5878905655607792 1.754499693723463 0.0793449223402458 1.0 0.3457562477939973 23 P35637,P05067,Q13501,Q06787,P04062,O96008,O43464 7 +Diplopia 0.6621537249818679 1.752841399073734 0.0796292347666158 1.0 0.3466536470204154 15 O14773,P01889,P04062,O43464,O00170 5 +Abnormality of the odontoid process 0.8687312257994453 1.7486001211624735 0.0803601653559078 1.0 0.3477562378808526 6 P08236,P16278 2 +Abnormality of the pharynx 0.5181303072227835 1.7463027145080336 0.0807583644411313 1.0 0.3482918049975794 40 P01889,P54802,P54132,Q03519,P08236,P15586,P16278,Q13510 8 +Cerebral white matter atrophy 0.648293139138785 1.7454143000236555 0.0809127782619705 1.0 0.3482918049975794 16 Q9Y263,O75503 2 +Abnormal iliac wing morphology 0.8189184242989289 1.7434244394932332 0.0812595023560216 1.0 0.3486047699150919 7 O95831,P16278 2 +Arthritis 0.5475854332723095 1.7434234824509542 0.0812596694059371 1.0 0.3486047699150919 34 P06280,P10321,O00170,P01889,P04062,Q14108,Q14739,Q13510 8 +Upper limb asymmetry 0.7698898408812751 1.7419748133540691 0.0815128515622602 1.0 0.3490138842786808 2 Q15555 1 +Hypohidrosis 0.8183676572744776 1.741313093086378 0.0816287123963588 1.0 0.3491719486741731 7 P06280,P07686 2 +Decreased specific antibody response to protein vaccine 0.7690738474092227 1.738351998523142 0.0821488092275242 1.0 0.35021887072397 2 Q13546 1 +Hypercholesterolemia 0.7245626283985038 1.7375260064037208 0.0822943677103207 1.0 0.35021887072397 9 Q15904 1 +Cerebral calcification 0.5676928148310028 1.7367324513877374 0.0824344069395626 1.0 0.35021887072397 28 P05067 1 +Abnormal periventricular white matter morphology 0.5578469050384123 1.734244757694344 0.0828746646013955 1.0 0.35021887072397 31 P17900,O75503 2 +Hypertrophic cardiomyopathy 0.4496088680303904 1.7332642770464073 0.0830487070580063 1.0 0.35021887072397 89 Q96AX1,P38398,Q9H0R6,P06280,Q15056,P01889,P10253,Q13423,P54802,O00170,P16278,P15586 12 +Hypertonia 0.412614056206018 1.73321683781784 0.0830571353717863 1.0 0.35021887072397 286 P05067,O00584,O75503,P11117,P61916,P17900,Q8NC96,P50897,O43505,Q9Y263,P16278,P06865,Q99519,Q5MNZ6,P07686,O15118,Q13510,Q13501,Q9UBM7,Q15392,P04062,Q14739,Q15056,P67870,Q01105,O43464,Q96C86,O95831 28 +Sound sensitivity 0.7692476270219443 1.7331810444866254 0.0830634950702178 1.0 0.35021887072397 8 P17900 1 +Hyperacusis 0.7692476270219443 1.7331810444866254 0.0830634950702178 1.0 0.35021887072397 8 P17900 1 +Mesomelia 0.8598308807271678 1.732303485375604 0.0832195417433625 1.0 0.35021887072397 5 Q9UBM7 1 +Abnormal macular morphology 0.5718004827139309 1.7307245868423136 0.0835008978578646 1.0 0.3504027241227089 26 Q99519,P50897,Q13510 3 +Fasciculations 0.5680867024137823 1.722709918734301 0.0849409957496329 1.0 0.3516154907301678 27 P06280,P07686,Q13501,Q13510 4 +Skeletal dysplasia 0.5481057703415361 1.7193493925284555 0.0855507712653032 1.0 0.3516154907301678 33 Q96AX1,Q99519,P10619,Q7Z2Z2,O95831,P16278,Q14739 7 +Hepatitis 0.699207475494426 1.7189782507854048 0.0856183322442665 1.0 0.3516154907301678 11 P11717 1 +Increased circulating lactate dehydrogenase concentration 0.685743779656453 1.7048084506854817 0.088230154924292 1.0 0.3586782860571176 12 P10253 1 +Myoclonic seizure 0.5104375921887297 1.70269758760786 0.0886246765709302 1.0 0.3589005520454773 42 Q99519,O75503,P07686,P67870,P04062,P16278,Q13510 7 +Low frustration tolerance 0.8082326566685809 1.7023936894148393 0.0886815922343475 1.0 0.3589005520454773 7 P04062,Q03164,Q9UHX1 3 +Aganglionic megacolon 0.6952216759566272 1.7014560993972685 0.0888573747133136 1.0 0.3589005520454773 11 P42892,Q9UBM7,Q96EK5 3 +Subcutaneous hemorrhage 0.549085464181445 1.7005054982657115 0.0890358830731938 1.0 0.3589005520454773 32 Q13126,Q99519,Q9NWM8,P04062,Q14108,Q8NCH0 6 +Abnormal bleeding 0.447601277992557 1.7004228092976352 0.0890514244459033 1.0 0.3589005520454773 88 P05067,Q99519,Q13126,Q9UHX1,P11117,Q9Y487,O00170,Q9NWM8,P04062,Q14108,Q8NCH0,Q14739 12 +Abnormal mitral valve physiology 0.5584496213545155 1.6966902717520551 0.0897552328525144 1.0 0.3589005520454773 29 Q96AX1,P06280,Q15056,P04062,O00170 5 +Abnormality of the upper respiratory tract 0.4558112265195243 1.6911829192573644 0.0908018722230632 1.0 0.3598715778159577 78 Q13501,Q9UBM7,Q9UHX1,P01889,Q92804,P54802,P54132,Q03519,Q14739,P08236,Q15165,Q7Z2Z2,O15460,P15586,P16278,Q13510 16 +Abnormal acetabulum morphology 0.6607221493167313 1.6899445791730363 0.0910385578971393 1.0 0.3604866083966404 14 P08236,P16278 2 +Skeletal muscle hypertrophy 0.5307705583115296 1.6888517774264136 0.0912478384529955 1.0 0.3609921193896238 36 Q15056,P07686,P10253,O00170,P16278 5 +Poor wound healing 0.8476746648164761 1.686667503286577 0.0916673040713487 1.0 0.3616810757427077 5 P04062,O15269 2 +Diaphragmatic eventration 0.7564259485924156 1.6820995944677972 0.0925495290179556 1.0 0.3645116356602118 2 O60568 1 +Sensory axonal neuropathy 0.6685527731305624 1.6748686858651145 0.0939599987632071 1.0 0.3674492259325068 13 Q8IV08 1 +Abnormal enzyme coenzyme activity 0.4230671759834536 1.6713685058975336 0.0946489126727745 1.0 0.3692787339041352 148 Q13501,O43772,Q15904,P07686,P10619,P61916,O15118,P10253,P04062,Q14739,O43505,P38571,P16278,Q13510 14 +Hypomimic face 0.7998964964981958 1.6702886867344071 0.0948622604305167 1.0 0.3692787339041352 7 P04062 1 +Acetabular dysplasia 0.7984581924139819 1.6647410629424166 0.095964426824741 1.0 0.3716730821767335 7 P08236,P16278 2 +Hepatic fibrosis 0.5625667214905758 1.661811593140586 0.0965505570181335 1.0 0.3726379700621332 25 P38571,Q15904,Q13510 3 +Abnormal retinal morphology 0.4271861068460191 1.6581990317596231 0.0972773001630538 1.0 0.373811901495384 167 Q9UHX1,O75503,P17900,Q8NC96,P50897,P54132,O43505,P16278,P06865,Q99519,P07686,P10619,Q9Y487,O14773,Q13510,P55011,Q96AX1,P04062,Q15056,Q8NCH0 20 +Sleep disturbance 0.4090436541446413 1.6571776444879938 0.0974835648975416 1.0 0.3739547333406995 118 Q9UBM7,Q9UHX1,O75503,Q15056,P67870,O00170,P04062,P50897,P54802,Q01105,O43464,Q10471,Q96C86,O95831,P15586 15 +Vascular skin abnormality 0.4343295584430689 1.6567304218783685 0.0975739895384448 1.0 0.3739772579970031 95 Q13126,Q99519,Q9UBM7,P06280,P10619,Q9Y487,O00170,Q9NWM8,P04062,P54132,Q14108,Q8NCH0,P16278,Q14739 14 +Spasticity 0.4262961457052796 1.654893406033197 0.0979461220690172 1.0 0.3744301624125005 237 O00584,O75503,P11117,P61916,P17900,Q8NC96,P50897,O43505,Q9Y263,P16278,Q99519,Q5MNZ6,P07686,Q9Y487,O15118,Q13510,Q13501,P55011,Q15392,P04062,Q7Z6Z7,Q9P032,Q15056,P67870,Q92804,Q01105,O60701,O43464,Q96C86,O95831,Q15165 31 +Abnormal immune system morphology 0.4109510889251603 1.6492554726965545 0.0990953076830896 1.0 0.3770439270762546 123 Q96AX1,Q99519,Q15904,Q14126,P61916,P02786,O15118,P01889,O15143,P04062,O43464,P54132,Q14739,P38571,Q7Z2Z2,Q14108,P16278,Q13510 18 +Protuberant abdomen 0.8433948169267287 1.6479974468880942 0.0993531950974411 1.0 0.377525070374555 4 P38571 1 +Eeg with spike wave complexes 0.7470064880750806 1.6434585558286303 0.100288093429675 1.0 0.3807504182312898 8 O75503 1 +Dysdiadochokinesis 0.6609078003244919 1.6394645181163867 0.1011165544117194 1.0 0.3823073893405179 13 O75503 1 +Migraine 0.608344762256422 1.6378399886226025 0.1014550773110456 1.0 0.3828803813538864 18 P05067,O00170 2 +Perseveration 0.7452858654164398 1.6364894745701837 0.1017371867774579 1.0 0.3830550047412382 8 P61916 1 +Abnormal lumbar spine morphology 0.7434866627298955 1.629197984806226 0.1032711134462363 1.0 0.387307091010605 8 P08236,P04062 2 +Abnormal form of the vertebral bodies 0.4530891233763515 1.625315698776273 0.1040953080814517 1.0 0.387307091010605 68 Q99519,Q9UBM7,Q15056,P54802,Q14739,P08236,O95831,P16278,P15586 9 +Kyphosis 0.4048200721909055 1.6252536758359235 0.1041085176018572 1.0 0.387307091010605 115 Q9UHX1,Q14108,Q9Y263,P16278,Q99519,Q5MNZ6,Q9Y487,O00170,P55011,Q96AX1,Q9UBM7,P01889,P04062,P08236,Q14739,Q9P032,Q15056,Q9NWM8,O95831,Q8NCH0 20 +Abnormal cardiac test 0.6576258633003854 1.6242314464944283 0.1043264218361208 1.0 0.3874355699254093 13 P10253 1 +Short middle phalanx of finger 0.8363265306122437 1.6232039329651464 0.104545817386076 1.0 0.3876061182355815 3 Q03164,Q9UHX1 2 +Abnormality of the ribs 0.4957046326910101 1.623195523336426 0.104547614527481 1.0 0.3876061182355815 46 Q9UBM7,P54802,O95831,P15586,P16278,Q14739 6 +Progressive psychomotor deterioration 0.7872410282206546 1.6213947208981332 0.1049330122242775 1.0 0.3887091399229309 7 P16278 1 +Abnormal saccadic eye movements 0.6141019757636188 1.61908600273463 0.1054287600270125 1.0 0.3898924795982244 17 Q8IV08,O14773 2 +External ear malformation 0.6957558882852873 1.6154788174362815 0.1062070439348707 1.0 0.3919087771669185 9 Q00577,P07437,Q15555,Q8NCH0,P38398 5 +Bone fracture 0.8271833701924141 1.6094103166492355 0.107526650913488 1.0 0.3950086187627554 5 Q13501 1 +Abnormal liver morphology 0.4257910451011304 1.603484323990155 0.108827767325154 1.0 0.3994566098582212 185 Q99519,O43772,Q15904,P07686,P10619,P61916,O15118,P10253,P04062,P54802,Q14739,P08236,P38571,P11717,Q14108,Q13510,P16278,P15586 18 +Retinal degeneration 0.4891355600035935 1.601917073438131 0.1091739484656284 1.0 0.4003950033693819 49 P55011,Q9UG56,O75503,O14773,Q8NC96,P50897,P04062,Q13510 8 +Cutaneous photosensitivity 0.581547217582004 1.6010315910169777 0.1093699223260658 1.0 0.4004496410994942 20 Q14108,Q9UBM7 2 +Abnormally lax or hyperextensible skin 0.5264588636793422 1.5998819821338404 0.1096247671515409 1.0 0.4006814380056315 34 Q15904,Q9UHX1,Q15056,Q9NWM8,P04062,Q8NCH0 6 +Hypoplastic vertebral bodies 0.8244973177646124 1.5992545660773818 0.1097640503457118 1.0 0.4006814380056315 5 P16278 1 +Atlantoaxial abnormality 0.8298945370448241 1.5981212986566946 0.1100159844191865 1.0 0.4006814380056315 3 Q9NWM8 1 +Abnormal renal tubule morphology 0.6302060193710258 1.5974835862587 0.1101579535642884 1.0 0.4006814380056315 15 P06280,Q15056 2 +2 3 toe cutaneous syndactyly 0.736842105263161 1.5946673455522442 0.1107866439507132 1.0 0.4019764775996829 2 P27635 1 +Lack of peer relationships 0.7368421052631587 1.594667345552235 0.1107866439507152 1.0 0.4019764775996829 2 Q96CW1 1 +Respiratory tract infection 0.4072886762364783 1.5744540897408448 0.1153825074076526 1.0 0.4123156747083517 128 P02786,P10253,P54132,P16278,P15586,Q00577,Q99519,Q9UID3,Q9Y487,P54802,Q13510,Q96AX1,P01889,P04062,Q03519,Q7Z2Z2,P08236,O95721,Q15056,O15460 20 +Meningitis 0.8170661990426134 1.5711258544952167 0.1161534182019399 1.0 0.412316668304318 5 P01889,P02786 2 +Recurrent aspiration pneumonia 0.8189814084494037 1.5650967786813823 0.1175602187915796 1.0 0.4166417048999653 6 Q13510 1 +Abnormality of corneal size 0.531737716678089 1.5637674358135991 0.1178721943541296 1.0 0.4173379323815851 31 Q15056,Q9NWM8,Q96EK5,O43505 4 +Metatarsus adductus 0.6835668963789384 1.563455988360401 0.1179453799405338 1.0 0.4173379323815851 9 Q15392,Q9UBM7 2 +Abnormal abdomen morphology 0.4217117575614896 1.5617355987639598 0.1183502888277003 1.0 0.4177778184304197 178 Q99519,O43772,Q15904,P07686,P10619,P61916,O15118,P10253,Q15392,P04062,P54802,Q14739,P08236,P38571,Q14108,Q13510,P16278,P15586 18 +Abnormality of the septum pellucidum 0.5266161464508157 1.5514998284487551 0.1207819484237431 1.0 0.4226412641441581 32 P55011,Q14738,Q9BZH6,Q15392,O43505,Q96C86 6 +Atrioventricular canal defect 0.8175479526656604 1.549059524213159 0.1213674116978527 1.0 0.4233084722291143 4 Q9UBM7 1 +Male sexual dysfunction 0.6700504240046568 1.5467007634201186 0.121935418942654 1.0 0.423993992125282 10 P07686,O00170,Q9BZH6,O43464 4 +Absent septum pellucidum 0.5372295184137564 1.5451516687146505 0.122309581680932 1.0 0.4246273781591543 28 P55011,Q15392,Q96C86,O43505 4 +Facial telangiectasia 0.8155102040816314 1.5419186011278143 0.1230933751676981 1.0 0.4250695509329787 3 Q07864,P54132 2 +Capillary hemangioma 0.8089481084308807 1.5403452616702569 0.1234762165111957 1.0 0.4260025784937745 5 Q9UBM7 1 +Beaking of vertebral bodies 0.811308755429201 1.5365917221137924 0.1243933209476331 1.0 0.4281706826674541 6 P08236,Q9UM00,P16278 3 +Mediastinal lymphadenopathy 0.8139290929791152 1.5351664787011752 0.1247429400737387 1.0 0.4287008733070292 4 P01889,O15460 2 +Lymphedema 0.6570890290682745 1.5324274139865115 0.1254169968397616 1.0 0.4300150209474926 11 P06280,P08236 2 +Elevated pulmonary artery pressure 0.6375061592981158 1.5304162464673032 0.1259137300843411 1.0 0.430238517128139 13 Q96AX1,P04062,Q14108,P01889 4 +Abnormal visual fixation 0.8126449531885598 1.53023443036338 0.1259587118224123 1.0 0.430238517128139 4 Q13510 1 +Acute coronary syndrome 0.5967159833132903 1.5294192948796814 0.1261605321646428 1.0 0.430238517128139 17 P06280,Q15056 2 +Abnormal femoral head morphology 0.6372775696550892 1.5293462915416534 0.1261786194269407 1.0 0.430238517128139 13 O95831,Q6NUQ1,P16278,Q7Z2Z2 4 +Abnormal oral mucosa morphology 0.4785632505146911 1.5282321416126026 0.1264549112065522 1.0 0.430238517128139 50 Q99519,Q9UBM7,Q15392,P04062,P08236,Q14108,P16278,Q14739 8 +Bicornuate uterus 0.8053640382558814 1.5267397294698664 0.1268257439397917 1.0 0.4311685360843189 5 Q9UBM7 1 +Aortic valve stenosis 0.8046829989638113 1.5241533543994037 0.1274704071519465 1.0 0.4320318856958312 5 P16278 1 +Bruising susceptibility 0.541362995325361 1.5230279376558369 0.1277517160012291 1.0 0.432653782445204 24 Q13126,Q9NWM8,P04062,Q14108,Q8NCH0 5 +Abnormal myeloid leukocyte morphology 0.4331606768260543 1.520828054567392 0.1283029922246261 1.0 0.4341883202827249 85 Q99519,Q14126,P61916,P02786,O15118,Q14739,P38571,P16278,Q13510 9 +Death in adulthood 0.6449282464237008 1.519570582051931 0.1286189361654139 1.0 0.4345924787315707 12 P05067 1 +Abnormal lower motor neuron morphology 0.7153194988222775 1.5145268540035164 0.1298922682091645 1.0 0.4382254022037641 8 Q13501,P35637,Q13510 3 +Abnormal elasticity of skin 0.4737303361600566 1.512463065449808 0.1304161017985075 1.0 0.4390337364109423 52 Q13126,Q15904,Q9UHX1,Q15056,Q9Y487,Q9H4L7,Q9NWM8,P04062,O00170,Q8NCH0 10 +Flat face 0.592969080150089 1.5100091052220008 0.1310411008516276 1.0 0.4393658448037271 17 Q9Y487,Q9UM00,Q03164,P08236,Q96C86,O60568 6 +Abnormality of bladder morphology 0.6615369908459001 1.5094563630430144 0.1311821987366794 1.0 0.4393658448037271 10 Q15056 1 +Abnormality of bone mineral density 0.394180319162459 1.5083727568864966 0.131459151490253 1.0 0.4393658448037271 113 Q13501,Q13126,P38398,P06280,Q15056,O95831,Q9Y487,O00170,Q9NWM8,P51809,Q15392,P04062,P54802,Q14739,Q7Z2Z2,Q14108,P16278,Q13510 18 +Bilateral tonic clonic seizure with generalized onset 0.7581191029889366 1.5082383998321476 0.1314935226086548 1.0 0.4393658448037271 7 Q00577,P04062,Q5VIR6,Q13510 4 +Abnormality of the alveolar ridges 0.8068940049214062 1.5081333145223323 0.1315204103064982 1.0 0.4393658448037271 4 Q9UBM7 1 +Death in infancy 0.48467281582853 1.5066897904344507 0.131890189720562 1.0 0.4398780332465742 42 Q15904,Q9H0R6,P04062,O43464,P38571,P16278 6 +Fat malabsorption 0.7121431691519182 1.5015385463468776 0.1332163245702537 1.0 0.4415264979826208 8 P38571,Q9UDY2,Q14739,Q7Z2Z2 4 +Pharyngitis 0.8050408597489371 1.500929701260597 0.1333737450721404 1.0 0.4415264979826208 3 P01889 1 +Gait ataxia 0.4657957997518636 1.5009225440005154 0.1333755964798468 1.0 0.4415264979826208 56 Q14108,Q8IV08,O14773,O15118 4 +Abnormal sella turcica morphology 0.8006683245952142 1.4969839714304054 0.1343974287761384 1.0 0.4436118115498959 6 P08236,Q96AX1,P16278 3 +Abnormal epiphyseal ossification 0.6301807718742821 1.4960853703929884 0.1346314097560346 1.0 0.4437218519753659 13 P08236,Q99519,Q9UBM7 3 +Barrel shaped chest 0.8036734693877532 1.4955716688579088 0.1347653106068314 1.0 0.4438324414102868 3 Q96AX1,Q14739 2 +Mask like facies 0.664381289840044 1.4811591259128047 0.1385641752816786 1.0 0.4536412637090041 9 P04062,Q14203,Q06787 3 +Depression 0.4304529153946945 1.4759803855106055 0.1399491578765967 1.0 0.455748060920412 83 Q13501,P55011,Q9BZH6,P06280,Q15056,P01889,Q92804,P04062,P50897,O43464,Q96C86,O00170,Q15165,O15460 14 +Abnormal lower limb bone morphology 0.394263366306026 1.47534102911034 0.1401208810033536 1.0 0.455748060920412 118 P55011,Q9UBM7,Q9UHX1,P06280,Q9Y487,Q5SRE5,Q15392,P04062,Q14739,Q10471,Q03164,O43505,P08236,Q7Z2Z2,O95831,Q9Y263,P16278,Q13510 18 +Generalized muscle weakness 0.5257413289245022 1.4720967183229834 0.1409947615712423 1.0 0.455748060920412 28 P35637,Q13501,Q92804,P10253,O95831,Q15165 6 +Telangiectasia of the skin 0.6037877561477399 1.4674370621095072 0.1422571986125795 1.0 0.4568406719316488 15 P06280,Q14739 2 +Hyperorality 0.7962278578818324 1.466380279735792 0.1425447156878405 1.0 0.4568406719316488 3 Q13501 1 +Severe short stature 0.5514065315029963 1.4649518912892414 0.1429340437498059 1.0 0.4568406719316488 21 P10619,P16278 2 +Anteverted ears 0.7078743370053082 1.4647690193933438 0.1429839470161011 1.0 0.4568406719316488 2 P27635 1 +Decreased circulating igg level 0.6505156089466989 1.4610939459938 0.1439896614139324 1.0 0.4577947819094653 10 Q15904,P54132 2 +Abnormality of the gastric mucosa 0.6020832516987877 1.459002607830363 0.1445643899268232 1.0 0.4584920813449751 15 P04062,Q14739 2 +Abnormality of the wrist 0.5555962714287773 1.4562734258811132 0.1453170486433108 1.0 0.4590980758209742 20 P16278,Q13510 2 +Involuntary movements 0.4091847411704766 1.4544609615407271 0.1458185491804147 1.0 0.4603536352783542 250 P05067,O00584,Q9UHX1,O75503,P06280,P61916,P17900,P50897,Q14108,Q99519,P07686,O14773,Q13510,Q13501,P04062,Q15056,P67870,Q01105,O43464,Q96C86,O95831 21 +Broad palm 0.7851905067645701 1.4499942548357332 0.1470601213289859 1.0 0.4629515420911778 5 Q14739 1 +Gastrointestinal obstruction 0.6382852366694767 1.4482364205832 0.1475509420593956 1.0 0.4641662992380562 11 P42892,P38398 2 +Postural tremor 0.6098013002720055 1.4464043837632314 0.1480638130177949 1.0 0.4648723339616329 14 P35637,Q14108,O14773 3 +Elevated circulating aspartate aminotransferase concentration 0.6457324340467874 1.4400570375665742 0.1498512626669781 1.0 0.4680230324927186 10 Q15904 1 +Dilation of virchow robin spaces 0.7021623827009429 1.4390996516740766 0.1501222907179888 1.0 0.4680230324927186 2 P27635 1 +Atypical absence seizure 0.7021623827009406 1.4390996516740673 0.1501222907179915 1.0 0.4680230324927186 2 Q96CW1 1 +Incoordination 0.4616129355529684 1.4376475843687408 0.1505340722541177 1.0 0.4685518659957514 54 Q13501,O75503,O14773,P04062,Q13510 5 +Joint stiffness 0.4678816015247584 1.431447916695756 0.1523018838706786 1.0 0.4707545910173553 49 Q96AX1,O75844,Q15056,P01889,Q9Y2U8,P54802,P50402,O15460,P08236,P16278,P15586 11 +Generalized abnormality of skin 0.4108766266844971 1.4242428006781396 0.1543761990014753 1.0 0.4758824033865075 176 Q13126,P06280,P61916,P54132,Q14108,P16278,Q99519,Q15904,P10619,Q9Y487,Q9H4L7,O15118,P38571,O43772,Q9UBM7,P04062,O15269,Q14739,Q15056,Q9NWM8,Q8NCH0 21 +Reduced visual acuity 0.4139373320556462 1.4211710381437828 0.155267042132023 1.0 0.4764897071509182 94 P06865,Q9UHX1,Q07021,P07686,P01889,P17900,P50897,O43505,O00170,P16278 10 +Generalized joint laxity 0.632103578123532 1.420454027471863 0.1554755434301196 1.0 0.4765546282684816 11 Q8NCH0,Q9Y487,Q9UHX1 3 +Cardiac conduction abnormality 0.558406339696234 1.4199707691715575 0.1556161911499329 1.0 0.4766554109807157 19 P06280 1 +Pace of progression 0.3975864976352874 1.4195016791999302 0.1557528076554344 1.0 0.4767437150588142 134 Q13501,Q13126,O00584,Q5MNZ6,Q8IV08,O95831,O14773,Q9BUF5,P04062,P54802,Q14108,Q13510,P15586 13 +Ulnar deviation of the hand or of fingers of the hand 0.6907472345970869 1.4137875725363518 0.1574242835241439 1.0 0.4788988040442469 8 Q9UBM7 1 +Progressive spastic quadriplegia 0.7335290630140684 1.4120975687810664 0.157921234530223 1.0 0.4797291348400936 7 P17900 1 +Abnormality of pulmonary circulation 0.5819715685407103 1.4114837661594526 0.158102019015339 1.0 0.4799486822957066 16 Q96AX1,P04062,Q14108 3 +Disinhibition 0.4684406940808162 1.4012143964037247 0.1611499705266998 1.0 0.4848750473738731 45 P35637,P05067,Q13501,P55011,Q06787,Q8NC96,O96008,P04062,O43464,Q96C86 10 +Abnormal hdl cholesterol concentration 0.7788153817871715 1.3999665366386478 0.1615233394708477 1.0 0.4854466090363356 4 P38571 1 +Progressive spasticity 0.60931227617326 1.397829637544082 0.1621642320991405 1.0 0.486602712737109 13 P17900 1 +Aplasia hypoplasia affecting the fundus 0.5449062721186777 1.3961810572521298 0.1626599795137036 1.0 0.4877593826366854 20 Q99519,Q9BZH6,Q9UHX1 3 +Visual hallucinations 0.7775513524658765 1.395089151168145 0.1629889572808163 1.0 0.488084060970244 4 P04062 1 +Pectus carinatum 0.5199389063413784 1.3923697101542611 0.1638104718756468 1.0 0.4901878489591482 24 P55011,Q99519,P08236,Q9Y263,P16278 5 +Retinal detachment 0.6253723364738283 1.3901481996239626 0.1644838794553287 1.0 0.4912303840856981 11 Q14331,Q8NCH0,Q13045,O43505 4 +Abnormal platelet volume 0.6846933199045487 1.3888849803888197 0.1648677284462474 1.0 0.4912699229493468 8 O15143,P35579,Q14739 3 +Abnormal enchondral ossification 0.5380345741187216 1.3882777757513556 0.1650524769393464 1.0 0.4912699229493468 21 P08236,Q99519,Q9UBM7 3 +Abnormal protein glycosylation 0.6150810906683015 1.3824297752132615 0.1668397789568692 1.0 0.4932702823036313 12 Q10471,Q15904,Q9Y487 3 +Abnormal urine protein level 0.4591077203712336 1.3808668050052038 0.1673199181322522 1.0 0.4937012411101903 51 P06280,P04062,Q99519,Q14108 4 +Psychosis 0.5151817724719947 1.3805396864590338 0.1674205390893199 1.0 0.4937012411101903 26 P61916,O15118 2 +Abnormal tongue physiology 0.6056455249542982 1.3805023440888666 0.167432028411776 1.0 0.4937012411101903 13 P10253,Q13510 2 +Arterial rupture 0.7733704187138879 1.3766330944537786 0.1686257136089413 1.0 0.4962285637340967 3 Q9NWM8 1 +Slurred speech 0.723559711656337 1.372997310755356 0.1697531827274017 1.0 0.4974401898954059 7 Q99519,P16278 2 +Arteriovenous malformation 0.7714559031973289 1.3715624512037274 0.1701996896646826 1.0 0.4974401898954059 4 P08236 1 +Abnormality of cardiovascular system electrophysiology 0.4224407361718419 1.3684384073865252 0.1711748890546967 1.0 0.4990814332820853 79 Q99519,O43772,P06280,Q14126,Q15056,P10253,P42892,P04062 8 +Heart block 0.5836393854894952 1.3674370045165631 0.1714883701530491 1.0 0.4990927575840204 15 P06280 1 +Atrophic scars 0.7632137788299651 1.3661342470304867 0.171896830841379 1.0 0.499539870441143 5 Q9NWM8 1 +Aplasia hypoplasia involving the vertebral column 0.6108979458165588 1.363116134885906 0.1728459124753083 1.0 0.501318552446651 12 P08236,P16278,Q14739 3 +Metaphyseal widening 0.5921406581037878 1.3609149293325618 0.1735405749871734 1.0 0.5023363633300184 14 Q96AX1,O95831,P16278,Q14739 4 +Congestive heart failure 0.4502592245338108 1.355289656398806 0.1753252892226839 1.0 0.5051463289285211 55 P06280,P10253,P16278 3 +Psoriasiform dermatitis 0.7677935114556196 1.3547168900978728 0.1755077745014133 1.0 0.5051463289285211 3 P10321 1 +Abnormal arachnoid mater morphology 0.7625828833297592 1.354618281359618 0.1755392058700287 1.0 0.5051463289285211 6 Q15904,Q9UHX1 2 +Paralysis 0.4652506271487336 1.3518327995566908 0.1764288089369854 1.0 0.5070465379650985 41 Q13501,Q92804,P10253,P17900,P04062,Q15165 6 +Leukoencephalopathy 0.4215495280950324 1.3496635770036247 0.1771239206611274 1.0 0.5070906550577023 77 O00584,Q9UHX1,O75503,P67870,P17900,Q01105,O95831 7 +Hirsutism 0.4565710018159091 1.3496342600232585 0.1771333290283989 1.0 0.5070906550577023 50 Q96AX1,P54802,P08236,O00170,Q9Y263,P16278,P15586 7 +Polydactyly 0.4931952269919474 1.3474791020601136 0.1778259795300849 1.0 0.5080906378950683 33 Q00577,Q99519,Q9BW83,Q9UBM7,Q9UHX1,Q9UM00,P54132,Q9Y263,Q14739 9 +Adducted thumb 0.5302405370514094 1.3434092097932655 0.1791395063481962 1.0 0.5105245081044277 21 Q15056,P42892 2 +Annular pancreas 0.6805385556915561 1.3418498901463325 0.1796446720792803 1.0 0.5116345039321681 2 Q9Y4R8 1 +Abnormal urine metabolite level 0.3886902826618478 1.3363966632250466 0.1814196563907333 1.0 0.5156935348433248 129 Q99519,P06280,Q15056,P10253,P04062,P54802,P08236,Q14108,P16278,P15586 10 +Osteoarthritis 0.6304787324156514 1.3347015623401175 0.1819740420398061 1.0 0.5166053837882302 9 P04062,Q14108,O00170 3 +Lewy bodies 0.7543223258928583 1.33215395006583 0.1828096051689638 1.0 0.5186445693792989 5 P04062 1 +Neuronal loss in central nervous system 0.7125045709238225 1.3295744593992918 0.1836585178550676 1.0 0.5197195294132847 7 P04062,O15118 2 +Abnormality of the metacarpal bones 0.5012296343377436 1.328630633622507 0.1839698603190995 1.0 0.5200712588102931 29 P08236,Q9UBM7,P16278 3 +Delayed ability to sit 0.5945084413852048 1.3277734778841872 0.1842529511907602 1.0 0.5204028116965087 13 P10253,Q10471,O60701 3 +Cutis laxa 0.5092392212666597 1.326676272168114 0.1846157932785854 1.0 0.5206199977789375 24 Q15056,Q8NCH0,Q15904 3 +Microcornea 0.5272268736610748 1.3260282637329266 0.1848303356393221 1.0 0.5207035506577847 21 Q9NWM8,O43505 2 +Impaired proprioception 0.4925422744550966 1.3222248482948404 0.1860932891016902 1.0 0.5232616768574544 32 Q8IV08,O14773 2 +Weakness of muscles of respiration 0.5055660141206201 1.320153264086389 0.1867838522565779 1.0 0.5245136458758269 26 P10253,Q13510 2 +Stereotypy 0.4503781531408406 1.3197881804404632 0.186905748935509 1.0 0.5245136458758269 52 Q13501,Q14738,P55011,Q9UHX1,P67870,P61916,Q01105,Q03164,Q7Z6Z7,Q96C86 10 +Supranuclear gaze palsy 0.5562648795933018 1.3184712855081742 0.1873459312512826 1.0 0.5245136458758269 17 Q13501,P61916,O15118 3 +High frequency sensorineural hearing impairment 0.7575794607347628 1.317973211293305 0.1875126157503865 1.0 0.5245136458758269 4 Q9NWM8,Q13510 2 +Corneal erosion 0.757450974874894 1.3174768941057082 0.1876788211235027 1.0 0.5245136458758269 4 Q96EK5 1 +Dyspareunia 0.7573309099093988 1.3170131042261035 0.1878342320991828 1.0 0.5245136458758269 4 O00170,P01889 2 +Metaphyseal striations 0.7569044201290787 1.3153656412122792 0.1883870470479478 1.0 0.5245136458758269 4 Q13126 1 +Abnormality of the liver 0.4033893900353527 1.31526399092258 0.188421195610912 1.0 0.5245136458758269 233 P61916,P10253,P11717,Q14108,P16278,P15586,Q99519,Q15904,P07686,P10619,O15118,P54802,P38571,Q13510,O43772,Q9UBM7,P04062,P08236,Q14739,Q07021 20 +Impotence 0.6665293478824011 1.3140122376259806 0.1888420860221504 1.0 0.5245136458758269 8 P07686,O00170,Q9BZH6 3 +Erectile dysfunction 0.6665293478824011 1.3140122376259806 0.1888420860221504 1.0 0.5245136458758269 8 P07686,O00170,Q9BZH6 3 +Bladder diverticulum 0.6664854129181266 1.3138308950328046 0.1889031182304239 1.0 0.5245136458758269 8 Q15056 1 +Abnormal speech prosody 0.7495243184384744 1.313809571740278 0.1889102956997947 1.0 0.5245136458758269 5 P04062 1 +Monotonic speech 0.7495243184384744 1.313809571740278 0.1889102956997947 1.0 0.5245136458758269 5 P04062 1 +Apraxia 0.4467182304229247 1.3125816546305835 0.1893239546902316 1.0 0.5251762412997311 54 P35637,P05067,Q00577,Q13501,P55011,Q7Z392,O14773,P04062,Q7Z6Z7 9 +Generalized onset seizure 0.4177858517961884 1.3123964233867944 0.1893864130393558 1.0 0.5251762412997311 77 P55011,Q99519,O75503,P67870,P04062,Q01105,Q96C86,Q14108,Q9Y263,P16278,Q13510 11 +Disproportionate short stature 0.5470186024718506 1.3114848866103148 0.189693996501405 1.0 0.5253731011570172 18 Q9UBM7,Q9UHX1,Q15392,P16278,Q14739 5 +Thick lower lip vermilion 0.4691306209032742 1.3084527395550805 0.1907197943961787 1.0 0.5265628280988129 38 Q99519,P06280,Q15056,O60701,O00170,P15586 6 +Oculogyric crisis 0.6647955894174501 1.306855364701545 0.1912618377609543 1.0 0.526914390763529 8 Q01105,Q05639,P67870 3 +Abnormality of skull ossification 0.5969441993928297 1.2985565187052923 0.1940961681951041 1.0 0.5305855079894596 12 P54802 1 +Vertebral compression fracture 0.5693894741997642 1.2963636199203312 0.1948502395979208 1.0 0.5319892652725948 15 P04062,Q14108,O00170 3 +Hyperextensible skin 0.5956504380309281 1.2925612798357151 0.1961628387095153 1.0 0.5337805663208735 12 P04062,Q8NCH0,Q9NWM8 3 +Xerostomia 0.5685670280833904 1.2922541485930044 0.1962691450528044 1.0 0.5337805663208735 15 P55011,P35637,Q13501,Q92804,Q15165,Q14739 6 +Chronic pulmonary obstruction 0.7458901415208454 1.2920174113596707 0.1963511149455259 1.0 0.5337805663208735 6 P06280 1 +Saccadic smooth pursuit 0.750270528598597 1.2897391514292615 0.197141241133989 1.0 0.5349421530893457 4 O14773 1 +Increased circulating androgen concentration 0.6682986536107756 1.2868059272773642 0.1981619404815158 1.0 0.5370528570770493 2 O14802 1 +Abnormal biliary tract morphology 0.5499605112550311 1.2853564656107963 0.1986677467790127 1.0 0.5380939644847358 17 Q14108,P04062 2 +Abnormal circulating igg level 0.5930649034898706 1.2805757829915037 0.2003427106042541 1.0 0.5406441787691373 12 Q15904,P54132 2 +Hepatic failure 0.4643989750055515 1.2733190724786343 0.2029048414992971 1.0 0.5458879067403704 38 P38571,O43772,Q13510,O15118 4 +Restlessness 0.4757811531687647 1.2725924373875563 0.2031627035868213 1.0 0.5458879067403704 35 P35637,P05067,Q13501,Q92804,P42892,O96008,P04062,O43464,Q15165 9 +Upper motor neuron dysfunction 0.3824433829264119 1.2725789185752727 0.2031675032882391 1.0 0.5458879067403704 289 O00584,O75503,P11117,P61916,Q13423,P17900,Q8NC96,P50897,O43505,Q9Y263,P16278,Q99519,Q5MNZ6,P07686,Q9Y487,O14773,O15118,Q13510,Q13501,P55011,P01889,Q15392,P04062,Q7Z6Z7,Q9P032,Q9BZH6,Q15056,P67870,Q92804,Q01105,O60701,O43464,Q96C86,O95831,Q15165 35 +Intracranial hemorrhage 0.5174810872741301 1.26971038193037 0.2041878133033177 1.0 0.5465338307653049 21 P05067 1 +Female sexual dysfunction 0.7399154474017097 1.269596016162847 0.2042285692118564 1.0 0.5465338307653049 6 O00170,P01889,O43464 3 +Horizontal nystagmus 0.5295456870289618 1.2610608680179514 0.2072869179798677 1.0 0.5509795902794201 19 P04062,O14773 2 +Proportionate short stature 0.4857626424553043 1.258071185427068 0.2083660130618083 1.0 0.5528511552323805 31 Q15392,P10619,P16278 3 +Intestinal malrotation 0.515018099711481 1.2554531768820896 0.2093142955424636 1.0 0.5545372098487803 21 Q15392,Q8NCH0,Q9UBM7,Q14739 4 +Coxa valga 0.587611467686409 1.2552787030445047 0.2093776035377488 1.0 0.5545372098487803 12 P55011,P16278,O75844 3 +Abnormality of lipoprotein cholesterol concentration 0.6036222963389045 1.25384586023251 0.2098980365429845 1.0 0.5552011912033066 10 P38571,Q10471 2 +Uncombable hair 0.6609547123623045 1.2538025058230884 0.2099137981889947 1.0 0.5552011912033066 2 Q15477 1 +Abnormal larynx physiology 0.5694107323858528 1.2503191560463482 0.2111829834686007 1.0 0.5572709176569418 14 Q13501,P35637,Q92804,Q15165,Q13510 5 +Orthostatic hypotension 0.5943800798249325 1.250021395749905 0.2112917316099234 1.0 0.5572709176569418 11 P07686 1 +Acne 0.5934705580802311 1.2458976128000474 0.2128019866147701 1.0 0.5603654896609941 11 O00170,Q92542 2 +Enlarged thorax 0.6016535669810681 1.2451068790057136 0.2130924658537911 1.0 0.5603654896609941 10 Q96AX1,Q32P28,O75844,P08236,Q14739 5 +Abnormal intraocular pressure 0.7386688444262879 1.2449280581097808 0.2131581960957338 1.0 0.5603654896609941 4 O75533,Q8NCH0,P04439 3 +Thickened skin 0.4095995870448309 1.2448805715430826 0.213175653469688 1.0 0.5603654896609941 80 Q96AX1,Q99519,Q9BZH6,O75844,P06280,Q14126,O95721,Q7Z392,Q9H4L7,Q9NWM8,Q9Y2U8,P04062,P31751,Q7Z2Z2,O00170,O15269,P16278,Q14739 18 +High myopia 0.6496227124465874 1.2441683645967656 0.21343760424543 1.0 0.5603654896609941 8 P30533,Q9Y487,O15460,Q7Z2Z2 4 +Abnormal femoral neck head morphology 0.4802708227893397 1.2388630813746633 0.2153962078945563 1.0 0.5633986183357014 32 P55011,O75844,Q9Y487,Q6NUQ1,Q7Z2Z2,O95831,P16278,Q14739 8 +Abnormality of lower limb epiphysis morphology 0.6002458965412407 1.2388571994995985 0.2153983865262652 1.0 0.5633986183357014 10 O95831,O60568,Q6NUQ1,Q7Z2Z2 4 +Episodic pain 0.5999468574929068 1.2375294258990632 0.2158905968836066 1.0 0.5634186025763331 10 P07686 1 +Pelvic kidney 0.647724325697127 1.2363199510997491 0.2163396579264396 1.0 0.5634186025763331 8 Q15056 1 +Abnormal fear anxiety related behavior 0.4011363164474633 1.2348462744671698 0.2168877216414815 1.0 0.5636277278614998 90 P35637,Q8N0X7,Q13045,O75503,P06280,P17900,Q00577,Q06787,O00170,Q13501,P55011,Q14203,Q9UM00,Q03164,O43464,Q9BZH6,Q15056,Q92804,Q7Z6Z7,Q15165 20 +Cutaneous syndactyly of toes 0.7371428571428549 1.2342798547807066 0.217098639966442 1.0 0.5638445593491329 3 P27635,Q9H4L7 2 +Hyperkeratosis 0.4471502625301013 1.2328452336133986 0.2176335114579761 1.0 0.5643783291790747 45 Q99519,O75844,P06280,Q7Z392,Q14126,O95721,Q9H4L7,Q9NWM8,Q9Y2U8,P04062,O15269 11 +J shaped sella turcica 0.7355025136032699 1.2327020111117073 0.2176869612433871 1.0 0.5643783291790747 4 P08236,Q96AX1 2 +Deformed sella turcica 0.7355025136032699 1.2327020111117073 0.2176869612433871 1.0 0.5643783291790747 4 P08236,Q96AX1 2 +Postaxial hand polydactyly 0.6464961591262075 1.2312419806408936 0.2182323745014174 1.0 0.5654609211597945 8 Q9UM00,Q9UBM7,Q9Y263,Q14739 4 +Protruding tongue 0.6061804594834588 1.2291650795960505 0.2190099187519489 1.0 0.5670916106863501 9 Q99519 1 +Delirium 0.6552427580579379 1.2281528515388451 0.2193895940542043 1.0 0.5670916106863501 2 P26358 1 +Increased serum iron 0.7354455360044304 1.227616539947446 0.219590949867771 1.0 0.5670916106863501 3 Q658P3 1 +Aspiration pneumonia 0.4920761853873511 1.227168319024094 0.219759334157652 1.0 0.5670916106863501 25 P16278,Q13510 2 +Recurrent sinopulmonary infections 0.7267808170032162 1.2268275009955163 0.2198874321336401 1.0 0.5670916106863501 5 P02786 1 +Joint swelling 0.7329494597094413 1.2228458411257987 0.2213879275444401 1.0 0.5699643792369375 4 Q13510 1 +Polymicrogyria 0.4282417678540637 1.2216565769563223 0.2218375236863285 1.0 0.570789626099262 59 P55011,P67870,Q9Y487,Q96EK5,Q15392,Q01105,O43505,Q96C86 8 +Abnormal sternum morphology 0.4045211957998127 1.2179727872334865 0.2232343140848935 1.0 0.5730501283792713 84 P55011,Q96AX1,Q99519,Q9UHX1,Q15056,Q9Y487,P04062,Q9Y263,Q14739,P08236,O95831,Q8NCH0,P16278,Q13510 14 +Vertical supranuclear gaze palsy 0.5954507023570421 1.21756126545991 0.2233907415337568 1.0 0.5730888423364348 10 P61916,O15118 2 +Slow saccadic eye movements 0.5953809710809892 1.2172515145228422 0.2235085356161767 1.0 0.5730888423364348 10 Q8IV08 1 +Thick vermilion border 0.4141170474851218 1.215938874109072 0.2240082080338581 1.0 0.5740372561609238 66 Q96AX1,Q99519,P38398,P06280,Q15056,Q96EK5,Q10471,Q01105,O60701,O00170,P15586 11 +Abnormality of lower lip 0.4335201592343294 1.2129585012509627 0.2251456870547172 1.0 0.5766180508645132 55 Q99519,P06280,Q15056,Q96EK5,P04062,O60701,O00170,P15586 8 +Congenital hypothyroidism 0.7302286677094849 1.212344263309299 0.225380626863265 1.0 0.5768857133195724 4 Q13423 1 +Aortic dissection 0.7286503442095627 1.2062534767273116 0.2277197700822251 1.0 0.5816392649563092 4 P01889 1 +Leukopenia 0.4468101803126331 1.2055377077153493 0.2279957902882579 1.0 0.5816392649563092 40 Q96AX1,Q15904,P04062,Q7Z2Z2,P38571,Q14108 6 +Dystonia 0.3780297770094868 1.201886395793203 0.2294075459481621 1.0 0.5833579453495096 129 Q13501,O00584,P67870,P61916,O15118,P17900,P04062,Q01105,O43464,P16278 10 +Amaurosis fugax 0.5998736719511786 1.2017291861268222 0.2294684693905839 1.0 0.5833579453495096 9 Q9ULM3,P01889 2 +Abnormality of the 5th toe 0.7202004541999324 1.2016686444041682 0.2294919341867842 1.0 0.5833579453495096 5 Q9UBM7,Q14739 2 +Postaxial foot polydactyly 0.7202004541999324 1.2016686444041682 0.2294919341867842 1.0 0.5833579453495096 5 Q9UBM7,Q14739 2 +Abnormality of circulating enzyme level 0.4052004629221333 1.195534654858358 0.2318782048040306 1.0 0.5860638519665348 79 Q13501,O43772,Q07021,Q14126,Q15056,Q9NWM8,P10253,O43505,O95831,O14979 10 +Endocarditis 0.7185934981209707 1.1955262928590658 0.2318814698036255 1.0 0.5860638519665348 5 P04062 1 +Abnormal bone structure 0.3836671042938583 1.1950827855972883 0.2320546870135287 1.0 0.5861666936955097 143 Q13126,P06280,Q14108,P16278,Q99519,Q9Y487,P54802,O00170,Q13510,Q13501,Q9UBM7,P51809,Q15392,P04062,Q7Z2Z2,P08236,Q14739,P38398,Q9UG56,Q15056,Q9NWM8,O95831 22 +Genu valgum 0.4878037531634231 1.1943677125090078 0.2323341609967397 1.0 0.586203077061369 24 P08236,P16278 2 +Neurodegeneration 0.4851913198835299 1.191569204381651 0.2334302061408402 1.0 0.5875671871400459 26 Q13501,Q92804,P17900,P08236,Q15165 5 +Unusual infection 0.3889820972335095 1.1913953876602292 0.2334984027630517 1.0 0.5875671871400459 159 P02786,P10253,Q13423,P54132,P16278,P15586,Q15904,Q9Y487,P54802,Q13510,Q96AX1,Q9UBM7,P01889,O15143,P04062,Q03519,Q7Z2Z2,P08236,Q14739,O75179,Q15056 21 +Posterior pituitary dysgenesis 0.7257187225950826 1.1894566540328546 0.2342600183327254 1.0 0.5875671871400459 3 Q9UHX1 1 +Impaired temperature sensation 0.7169778316863187 1.1893514051154228 0.2343014148130784 1.0 0.5875671871400459 5 P07686 1 +Abnormal electroretinogram 0.4834142381823638 1.1892632595319603 0.2343360882014562 1.0 0.5875671871400459 27 P50897 1 +Uric acid nephrolithiasis 0.6462668298653625 1.187893979933677 0.2348751817696799 1.0 0.5882519416575845 2 P07741 1 +Macroscopic hematuria 0.6462668298653625 1.187893979933677 0.2348751817696799 1.0 0.5882519416575845 2 P07741 1 +Areflexia 0.4167867984185325 1.1840896012003586 0.2363775960440688 1.0 0.59101080118876 63 Q13501,O95721,P10253,O60701,O43505,O95831,O15269,Q13510 8 +Abnormality of facial musculature 0.4297273280505906 1.18058173536776 0.2377689228976891 1.0 0.5931339899915603 55 Q13501,Q9UHX1,P10253,P04062,Q9Y263,Q13510 6 +Biliary tract abnormality 0.5065317549162076 1.178759776821669 0.2384938452006773 1.0 0.5942863534211806 20 P04062,Q14108 2 +Abnormality of facial soft tissue 0.3956394382045579 1.1759093877999036 0.2396310870523981 1.0 0.5952539845821538 90 Q13501,Q14738,Q99519,Q00577,Q9UBM7,Q9UHX1,O75844,Q15056,Q14203,Q9NQW6,Q9BUF5,P10253,P04062,O00170,Q9Y263,Q13510 16 +Bilateral polymicrogyria 0.7136725555510237 1.1711083934584383 0.2415552104810308 1.0 0.5978728013193056 6 P67870 1 +Broad foot 0.6719281173861388 1.1698977543042064 0.2420421177405449 1.0 0.5980739032214695 7 O95831,O00170,Q8IWS0 3 +Alkalosis 0.7113676646016713 1.1679169173279194 0.2428402794952591 1.0 0.59925452095442 5 O00170 1 +Abnormality of epiphysis morphology 0.4417936770210782 1.1668422362936912 0.2432740867451721 1.0 0.5997777512117595 40 Q99519,Q9UBM7,Q7Z2Z2,P08236,O95831,P16278,Q14739 7 +Functional abnormality of the gastrointestinal tract 0.394599654396181 1.1657060254649576 0.2437333231695715 1.0 0.6005752024395626 215 P35637,P05067,Q9UHX1,P06280,P61916,P42892,Q8NC96,P54132,Q14108,Q9Y263,P15586,Q99519,O15118,Q9BUF5,Q13510,Q13501,P55011,Q96AX1,Q9UBM7,P01889,O15143,P04062,Q03164,O15269,Q14739,P38398,Q15056,P67870,Q01105,P08183,O15460 31 +Abnormality of humoral immunity 0.436955098411712 1.1647041343437794 0.2441387749032997 1.0 0.6007967400700256 47 Q15904,P02786,P04062,P54132,Q14108 5 +Memory impairment 0.4717912517461654 1.1641417561446838 0.2443665691580321 1.0 0.6007967400700256 31 Q13501,P05067,Q06787,P01889,O96008 5 +Wide mouth 0.4323818933389431 1.1601760811037405 0.2459771232745811 1.0 0.6027461585836411 51 P55011,P51571,Q9UBM7,Q15056,P42345,Q9UM00,Q01105,O15160,Q7Z6Z7,P16278,P15586 11 +Dysuria 0.6679606578194989 1.1542844616318753 0.2483835647740351 1.0 0.6076330237807286 7 O00170,P01889 2 +Dermal atrophy 0.4783698178133447 1.1483720659110872 0.2508150003444609 1.0 0.6105419628638143 26 O75844,Q9NWM8,Q15392,Q8NCH0,O00170,Q15334 6 +Mutism 0.548309229328013 1.1472744374817982 0.2512682153834855 1.0 0.6107489384091194 14 Q13501,Q13510 2 +Abnormality of the larynx 0.4473442351902863 1.1462320740995218 0.2516991399450856 1.0 0.6107489384091194 38 Q13501,Q9UBM7,Q9UHX1,Q92804,Q7Z2Z2,Q15165,Q14739,Q13510 8 +Increased circulating antibody level 0.5714099103951523 1.145764748363464 0.251892504828779 1.0 0.6107489384091194 11 Q14108,P04062 2 +Abnormality of neutrophil morphology 0.7050635723435742 1.1438469583590325 0.2526871114981501 1.0 0.6117323996476838 5 P35579,Q14739 2 +Macular purpura 0.5375157068481708 1.1366912517957528 0.2556673777148093 1.0 0.6149085435740084 15 Q99519,P04062,Q8NCH0 3 +Recurrent hand flapping 0.7098372858757213 1.127279765936026 0.2596242145736518 1.0 0.623069940889453 3 Q06787 1 +Decreased fertility in males 0.6207614596458562 1.124826821004373 0.2606624265918227 1.0 0.6248834215802882 8 O00170,P51809,P54132 3 +Abnormal thoracic spine morphology 0.487495182319708 1.124318398444413 0.2608779759202781 1.0 0.6250613691741009 22 P08236,O95831,P04062,Q9UHX1 4 +Recurrent skin infections 0.5511860598839415 1.1216754522078989 0.2620004575441477 1.0 0.6253740574819417 13 P02786 1 +Respiratory failure 0.4253798913143163 1.1213483514621518 0.2621396117050689 1.0 0.6253740574819417 53 Q13501,P61916,Q92804,P10253,P54132,O43464,Q5SRE5,Q15165,Q13510 9 +Abnormal metacarpal morphology 0.4816321363271761 1.1209525354400185 0.262308066764285 1.0 0.6254385872228746 23 P08236,P16278 2 +Postaxial polydactyly 0.5508366294068904 1.1200099782376711 0.2627095100000476 1.0 0.6257211430965054 13 Q9UM00,Q9UBM7,Q9Y263,Q14739 4 +Decreased testicular size 0.5114611327452974 1.1195180073356548 0.2629192130584892 1.0 0.6258041195024946 18 Q9BZH6,Q06787,P27635,P51809,Q8IWS0,O43505 6 +Abnormality of the nasolabial region 0.6984106053845753 1.118467916373438 0.2633672018014064 1.0 0.625939351728974 5 Q8NCH0 1 +Prominent nasolabial fold 0.6984106053845753 1.118467916373438 0.2633672018014064 1.0 0.625939351728974 5 Q8NCH0 1 +Recurrent gastroenteritis 0.7072064647550202 1.1169999751796476 0.2639943358005971 1.0 0.6262505909245266 3 P54132 1 +Dyscalculia 0.6188279525793975 1.1168358542863417 0.2640645155040113 1.0 0.6262505909245266 8 Q13501,P35637 2 +Motor seizure 0.3974723541770809 1.1136412579594264 0.2654331191274299 1.0 0.6279403157461706 78 Q99519,O75503,P07686,P67870,P04062,Q01105,P16278,Q13510 8 +Focal non motor seizure 0.6573449427879157 1.1125324401196426 0.2659092902117148 1.0 0.6279403157461706 7 P67870 1 +Focal emotional seizure 0.6573449427879157 1.1125324401196426 0.2659092902117148 1.0 0.6279403157461706 7 P67870 1 +Abnormal shape of the palpebral fissure 0.6573019511503343 1.1123634465230985 0.2659819144885986 1.0 0.6279403157461706 7 O75179,Q9UHX1 2 +Hyposmia 0.556449023760747 1.1104440099289077 0.2668077425067241 1.0 0.6280418547670253 12 Q9BW83,P04062,Q9BZH6,O43464 4 +Malnutrition 0.6960131731621548 1.1093292822743457 0.2672881572954013 1.0 0.6281697766830819 5 P38571 1 +Hypolipoproteinemia 0.6965601669723931 1.1069734806553269 0.2683053941829783 1.0 0.6300416507382511 6 P38571 1 +Cupped ear 0.570484411544883 1.1066055706439188 0.26846449777236 1.0 0.6300416507382511 10 P42892 1 +Atrophy degeneration affecting the cerebrum 0.3867638051554302 1.1053408912165532 0.2690119056680042 1.0 0.6302116836703299 176 Q13501,P05067,Q9UHX1,O75503,Q15056,P67870,O14773,P17900,P04062,P50897,Q01105,Q8NC96,O43464,Q96C86,O95831,P16278 16 +Weak voice 0.7021909847114416 1.104340273684703 0.2694455587744038 1.0 0.6302261800418762 4 P04062 1 +Bradycardia 0.6541100121577197 1.099819028834831 0.2714109796657395 1.0 0.6331491366358472 7 O43772 1 +Oligomenorrhea 0.6527219053839359 1.0943654370146088 0.2737947362905513 1.0 0.6363605457767253 7 O00170 1 +Abnormal heart valve physiology 0.4048865226266203 1.092446142810165 0.274637050708262 1.0 0.6374250759979014 64 Q96AX1,Q15904,Q9UHX1,P06280,Q15056,P04062,O00170,P16278 8 +Opisthotonus 0.4908101818743628 1.0891954554770729 0.2760677025647813 1.0 0.6396267409345352 20 P11117,P04062,O60701 3 +Metaphyseal chondrodysplasia 0.6967411223995266 1.083413421144282 0.2786249611339417 1.0 0.6438653098722176 4 O95831 1 +Abnormality of urinary uric acid concentration 0.6226030191758478 1.0821832080440572 0.2791711283846196 1.0 0.6444305989946943 2 P00492 1 +Dolichocephaly 0.4848047767305782 1.0800085935572137 0.2801383534241357 1.0 0.6450036112415161 21 Q14738,O95721,P27635,Q4J6C6,P54132,Q03164,P48444,P38398 8 +Abnormal circulating igm level 0.5563303282064973 1.0772837264688089 0.2813535302242496 1.0 0.6474644454640249 11 Q15904,P54132 2 +Abnormal umbilicus morphology 0.4282366642150848 1.072510918265585 0.2834906125969838 1.0 0.6508107705983355 43 Q99519,Q15056,Q9Y487,Q9NWM8,P08236,Q8NCH0,Q14739 7 +Abnormal glycosylation 0.5159152306625217 1.0720378546946074 0.2837030297932492 1.0 0.6508107705983355 16 Q15904,Q9Y487 2 +Tapered finger 0.4601025733839111 1.0713244203342966 0.284023583186527 1.0 0.6508761799266095 30 Q96EK5,Q9H4L7,P42892,Q03164,O00170,Q8NCH0 6 +Abnormal diaphysis morphology 0.4240593413704318 1.067223127708553 0.2858710912613547 1.0 0.6517566168293669 48 Q13126,Q15056,Q9Y487,P08236,O00170,P16278,Q14739 7 +Cachexia 0.5228142052251824 1.0629095540514657 0.2878229698968577 1.0 0.6536123857835868 15 P35637,P38571,P04062 3 +Petechiae 0.5601936713901129 1.0608933417491682 0.288738375508784 1.0 0.6536123857835868 10 Q99519 1 +Adrenal insufficiency 0.4660632594265047 1.0595557529050237 0.2893467523613899 1.0 0.6536123857835868 24 Q9H0R6,P51809,Q13423,P38571,O00170,Q658P3 6 +Hyperphosphatemia 0.6172990616075099 1.0586060139348354 0.2897792468882922 1.0 0.6536123857835868 2 Q15813 1 +Adrenocortical carcinoma 0.61729906160751 1.0586060139348354 0.2897792468882922 1.0 0.6536123857835868 2 P04637 1 +Primary hypercortisolism 0.6172990616075099 1.0586060139348354 0.2897792468882922 1.0 0.6536123857835868 2 P17612 1 +Abnormal urine hormone level 0.61729906160751 1.0586060139348354 0.2897792468882922 1.0 0.6536123857835868 2 P04637 1 +Increased urinary cortisol level 0.61729906160751 1.0586060139348354 0.2897792468882922 1.0 0.6536123857835868 2 P04637 1 +Adrenocortical abnormality 0.6172990616075099 1.0586060139348354 0.2897792468882922 1.0 0.6536123857835868 2 P17612 1 +Aplasia hypoplasia of the nasal bone 0.61729906160751 1.0586060139348354 0.2897792468882922 1.0 0.6536123857835868 2 Q6NUK1 1 +Congenital craniofacial dysostosis 0.61729906160751 1.0586060139348354 0.2897792468882922 1.0 0.6536123857835868 2 Q6NUK1 1 +Abnormal thyroid stimulating hormone level 0.6172990616075098 1.0586060139348354 0.2897792468882922 1.0 0.6536123857835868 2 O14654 1 +Rhizomelia 0.5595847431574378 1.0581899344494747 0.2899688592572711 1.0 0.6536123857835868 10 Q15392,Q9UBM7,Q14739 3 +Large forehead 0.6900960243595805 1.0579375701891218 0.2900839053342032 1.0 0.6536123857835868 4 Q96AX1 1 +X linked recessive inheritance 0.4274252873758005 1.055776760260991 0.2910702181220859 1.0 0.65516721361526 40 P06280,Q15904 2 +Abnormality of fluid regulation 0.3659494022657951 1.054870444356493 0.2914845812144626 1.0 0.6557661763537987 128 Q99519,Q9UBM7,Q9H0R6,P06280,Q15056,P10619,O00170,P04062,Q14739,P08236,Q14108,Q9Y263,P16278,Q13510 14 +Abnormal vena cava morphology 0.6809640522875825 1.0520685083437942 0.2927681192124014 1.0 0.6576502748991627 5 Q7LBC6,Q6ZRS2,P11766,P98175 4 +Abnormal lymphocyte morphology 0.4630696285425003 1.051331655363128 0.2931062931960153 1.0 0.6578453286622521 26 Q99519,P54132,P16278 3 +Supernumerary tooth 0.6806093221168362 1.0507212976934237 0.2933866114140724 1.0 0.6580370092720296 5 Q9UBM7 1 +Airway obstruction 0.5348606453483906 1.043885017459424 0.2965385908324416 1.0 0.6610837637358312 13 P06280,P54132 2 +Decreased facial expression 0.4898155269431828 1.0407394446297813 0.2979964912096275 1.0 0.6636648945720961 19 Q00577,Q06787,Q14203,P04062,Q14331,Q9Y263 6 +Aplasia hypoplasia involving the skeletal musculature 0.5620024719269295 1.0370222519093868 0.2997254869151171 1.0 0.6665087122300468 9 O43505 1 +Abdominal pain 0.3907568724861553 1.033631776416187 0.3013083382195212 1.0 0.6683457780933716 71 P35637,P06280,Q15056,P07686,P01889,Q13423,P42892,P04062,Q14108,O15460,P38398 11 +Thenar muscle atrophy 0.6857142857142831 1.0333112863554927 0.3014582471843265 1.0 0.6683457780933716 3 O60568,Q15120 2 +Abnormal pulmonary interstitial morphology 0.4588752114486786 1.0247127096051578 0.3054987642814351 1.0 0.6759484914541207 26 Q14108,Q13510 2 +Shuffling gait 0.5963739462354409 1.0241841104441294 0.3057483223906008 1.0 0.6761624149668136 8 P04062,Q14203,O75844 3 +Abnormal gastrointestinal motility 0.4595908492111889 1.019374615069202 0.3080251528437312 1.0 0.6798379496146821 24 P35637,Q9UBM7,P06280,Q01844,P38398 5 +Aphasia 0.4451558190357511 1.015488659360188 0.3098729497252712 1.0 0.6822325344274188 33 Q13501,P05067,Q7Z6Z7,P55011 4 +Abnormal morphology of the abdominal musculature 0.6713146511109847 1.0154710518529777 0.3098813388344301 1.0 0.6822325344274188 5 Q8NCH0 1 +Restrictive ventilatory defect 0.5490009982887691 1.011242012980611 0.3119006121194734 1.0 0.6854389876383872 10 Q7Z392,P01889,P16278 3 +Eeg with multifocal slow activity 0.6708923621769245 1.0111228208524887 0.3119576491331841 1.0 0.6854389876383872 6 Q8NC96,P61981 2 +Parkinsonism with favorable response to dopaminergic medication 0.5927492660983427 1.0092646049493104 0.3128477502725975 1.0 0.6867124563055577 8 P04062 1 +Purpura 0.489868183964212 1.0026604947888853 0.3160246968826543 1.0 0.6911273760777946 18 Q99519,P04062,Q8NCH0 3 +Megalocornea 0.5466400145287263 1.0007815826587223 0.3169324154315016 1.0 0.6915599770367695 10 Q15056 1 +Sensory ataxia 0.6750086062930263 1.000295827885098 0.3171673656633929 1.0 0.6917313897086719 4 P54802 1 +Abnormal leukocyte physiology 0.4119800248092404 0.9991174983263496 0.3177377754506421 1.0 0.6922926999104383 52 Q15904,P02786,P04062,P54132,Q14108 5 +Sensory neuropathy 0.4517995195000773 0.994654231052221 0.3199044618575895 1.0 0.693944802600436 28 Q8IV08,O15269 2 +Proximal muscle weakness 0.4168973663814527 0.9917290531143388 0.3213297145640461 1.0 0.6949835342380323 45 Q13501,P10253,Q13510 3 +Pathologic fracture 0.5438599402425411 0.9884715007112812 0.3229217852326353 1.0 0.6971000269526569 10 P04062,Q14108,O15269 3 +Deep plantar creases 0.6641672117712192 0.9884369082268066 0.3229387192462116 1.0 0.6971000269526569 5 O00170,Q9Y487 2 +Rigidity 0.4180785884282366 0.9834375465997806 0.3253921386824734 1.0 0.6984300527842136 40 Q15392,P04062,Q8NC96,O43464,P16278 5 +Submucous cleft of soft and hard palate 0.4790074078364351 0.9807610553156314 0.3267105874015903 1.0 0.6994389777721365 19 O43505 1 +Abnormality of exocrine pancreas physiology 0.4980089943179761 0.9797622503601056 0.3272034900622125 1.0 0.6998167488129429 16 Q15904,Q9UHX1,Q7Z2Z2 3 +Rimmed vacuoles 0.521181870294838 0.978808866701634 0.327674427824415 1.0 0.6999421450160256 13 Q13501,O14979 2 +Aortic valve calcification 0.6715920947316236 0.9786825203784084 0.3277368714284849 1.0 0.6999421450160256 3 P04062 1 +Generalized myoclonic seizure 0.4440829285313363 0.9772501107687518 0.3284453451253313 1.0 0.7011166802554731 31 Q99519,P67870,P04062,P16278,Q13510 5 +Eversion of lateral third of lower eyelids 0.5985312117503094 0.9756549508535858 0.3292354835414912 1.0 0.702125623772428 2 P60953 1 +Abnormal muscle fiber morphology 0.4055925180707939 0.9739301438329604 0.3300912254629948 1.0 0.7036113205893139 55 P35637,P05067,Q13501,Q7Z392,O95831,O96008,P50402,P51114,Q9H2D1,O14979,O43676 11 +Unilateral renal agenesis 0.4903584788444322 0.970967163034259 0.3315646307210389 1.0 0.705027542742162 17 O75179,Q9UBM7 2 +Hydrocephalus 0.4035077353665282 0.9667431207818772 0.3336724649910558 1.0 0.705027542742162 56 Q99519,Q9UBM7,Q15392,P04062,O43505 5 +Abnormal pericardium morphology 0.5386103898277405 0.9652503520717298 0.3344194324808167 1.0 0.705027542742162 10 Q14108,P04062,P01889 3 +Decreased circulating iga level 0.5818649472776779 0.9645529930241112 0.3347687535394592 1.0 0.705027542742162 8 Q15904 1 +Skin nodule 0.4888449458903531 0.9629912535224026 0.3355519126107533 1.0 0.705027542742162 17 P06280,P01889,Q13510 3 +Abnormal femoral neck morphology 0.4498882618262795 0.9627021064108664 0.3356970393432044 1.0 0.705027542742162 25 O95831,Q9Y487,P16278 3 +Failure to thrive in infancy 0.4479612155045653 0.961821177122768 0.3361394383790541 1.0 0.7056216117468231 27 P42892 1 +Elevated hepatic transaminase 0.3809046692872816 0.9577305351262032 0.3381986550846807 1.0 0.7085990769490966 81 Q658P3,O43772,Q15904,Q07021,P01889,P10253,Q7Z2Z2,P38571,Q14739,Q13510 10 +Avascular necrosis 0.4810667147904834 0.9550923079501038 0.3395310185228504 1.0 0.7101074780971062 18 Q14108,P04062 2 +Eeg with abnormally slow frequencies 0.5089454652037702 0.9550334589889884 0.3395607768879447 1.0 0.7101074780971062 14 Q13501,O75503 2 +Inappropriate behavior 0.5156754005358721 0.9526625500202228 0.3407610738938955 1.0 0.7115791775935367 13 P17900 1 +Lambdoidal craniosynostosis 0.5932272541819701 0.9523726130821668 0.3409080437080498 1.0 0.7115791775935367 2 P61978 1 +Subcutaneous nodule 0.5005877699067433 0.9515328553261632 0.3413339481920028 1.0 0.7121321004024662 15 P06280,P01889,Q13510 3 +Abnormalities of placenta or umbilical cord 0.5220652347806386 0.9508169503023218 0.3416973064584119 1.0 0.7122182782589801 12 P16278 1 +Abnormality of the abdominal organs 0.3690135059089583 0.9483726898987735 0.342939757463196 1.0 0.7132612367516293 273 P61916,P10253,P11717,Q14108,P16278,P15586,Q99519,Q15904,P07686,P10619,O15118,P54802,P38571,Q13510,O43772,Q9UBM7,Q15392,P04062,P08236,Q14739,Q07021,Q15056,Q8NCH0 23 +Abnormal myeloid cell morphology 0.6613065960572131 0.9482464787067736 0.3430039906332163 1.0 0.7132612367516293 4 Q9UJV9 1 +Broad based gait 0.4794802126730476 0.9465264486137026 0.3438801387367332 1.0 0.714308566283506 18 Q00577,P61981,O14773,P04062,Q03164,O00571 6 +Recurrent infection of the gastrointestinal tract 0.6605963619810571 0.9455576619758622 0.3443742473004807 1.0 0.7147664457109462 4 P54132 1 +Focal motor seizure 0.4905281954773623 0.9412902749319932 0.346556125091833 1.0 0.71794741980383 16 P67870,O75503 2 +Gingival bleeding 0.5328224577112441 0.9396891077219311 0.3473770538685561 1.0 0.7190629848302994 10 Q14108 1 +Motor neuron atrophy 0.456314262109517 0.9391763881001997 0.347640189827187 1.0 0.7191598279451998 22 P35637,Q13501,Q92804,Q15165,Q13510 5 +Vertebral hypoplasia 0.5386300067620327 0.9358492420871456 0.3493508140314769 1.0 0.7210353011951576 9 P16278 1 +Soft skin 0.6118742692054868 0.93465169633178 0.3499678278731095 1.0 0.721635292625997 7 Q9NWM8 1 +Death in childhood 0.4554019473460792 0.9337673354696584 0.3504239224200567 1.0 0.7219026589957666 22 Q96AX1,O95721,P07686,Q9NPL8,Q6NUQ1,Q96IX5,O60828 7 +Morphological abnormality of the pyramidal tract 0.470411249581897 0.9331259114913636 0.3507549620236618 1.0 0.7221555742224305 19 P35637,Q13501,Q15056,Q14203,O95831 5 +Hypergalactosemia 0.5887392900856834 0.9327366348035768 0.3509559647831506 1.0 0.7221555742224305 2 Q9UJS0 1 +Hypokinesia 0.5740576283912338 0.9325806843193446 0.351036510191776 1.0 0.7221555742224305 8 P04062 1 +Abnormal circulating iga level 0.5304867380558427 0.9293878115088188 0.3526881421007934 1.0 0.7251381932630083 10 Q15904 1 +Rotary nystagmus 0.6586309570608897 0.9288753671704948 0.3529536801090394 1.0 0.7251381932630083 3 Q14738 1 +Bulbar palsy 0.5303597686204989 0.9288280813046644 0.3529781890335195 1.0 0.7251381932630083 10 Q13501,Q9Y263 2 +Infectious encephalitis 0.6485564195048803 0.928298523605394 0.3532527397136196 1.0 0.7253203960917675 6 Q14739 1 +Impaired mastication 0.647761957636294 0.925366128467736 0.354775491461794 1.0 0.7268749575068865 6 P01889,O15460 2 +Abnormal preputium morphology 0.6544487454752681 0.9223256385996272 0.3563587445166898 1.0 0.7290354888979274 4 P38398 1 +Abnormality of coordination 0.3728777506268939 0.9167057438817912 0.3592968554086799 1.0 0.7331167038108146 252 Q13501,P05067,Q99519,O00584,O75503,Q15056,P07686,Q8IV08,P61916,O14773,O15118,P04062,P50897,Q01105,Q14108,P16278,Q13510 17 +Motor axonal neuropathy 0.5146453043398663 0.9165224403166072 0.3593929431316214 1.0 0.7331167038108146 12 O95831,O15269 2 +Atrophy degeneration involving the corticospinal tracts 0.5145824594479895 0.9162323396552212 0.3595450468821599 1.0 0.7331167038108146 12 Q13501,P35637,Q15056 3 +Hyperlipidemia 0.4385531329583056 0.901512216901752 0.367316041162524 1.0 0.7428618427351823 27 P06280 1 +Decreased circulating total igm 0.6024069998406614 0.8979541981906861 0.3692099682029544 1.0 0.7456692645487065 7 Q15904 1 +Abnormality of the calf 0.4058667950823664 0.8962335061312213 0.370128064039716 1.0 0.7467597160686394 43 Q13126,Q15056,P08236,O95831,P16278 5 +Abnormality of circulating adrenocorticotropin level 0.6019203892940058 0.8960724118109143 0.3702140903874273 1.0 0.7467597160686394 7 Q13423 1 +Neonatal hypoglycemia 0.5650927079334493 0.8959931906226852 0.3702564000313195 1.0 0.7467597160686394 8 O43772,P31751 2 +Stillbirth 0.5226632499337244 0.8949506693365016 0.3708134589548044 1.0 0.7475423559512762 10 P04062 1 +Abnormality of the spinal cord 0.3982328584831899 0.8922673643218426 0.372249642527507 1.0 0.7482289514402063 53 P05067,P16278,Q15056 3 +Ascending tubular aorta aneurysm 0.6456183479726945 0.8890966959726245 0.3739511144662399 1.0 0.7483115402909907 4 P01889,Q06787 2 +Abnormal temper tantrums 0.5277145935438603 0.8888732989193886 0.3740711769349718 1.0 0.7483115402909907 9 Q14738,P04062 2 +Pericardial effusion 0.6371284346800351 0.886911891166437 0.3751263390725157 1.0 0.7496950588621096 5 Q14108 1 +Abnormality of the thoracic cavity 0.5207336709890268 0.8864746048217962 0.3753618328331631 1.0 0.7496950588621096 10 Q7Z2Z2,P01889,O15460 3 +Intractable diarrhea 0.6471961411587379 0.8852507162721331 0.3760214243384205 1.0 0.7497985644310554 3 Q15477 1 +Akinesia 0.5623474005887816 0.8848196038510929 0.3762539344982296 1.0 0.7497985644310554 8 P51114,P04062,Q14203 3 +Nonimmune hydrops fetalis 0.4471161783403554 0.884697220169433 0.3763199553722347 1.0 0.7497985644310554 22 P04062,P10619,Q14739 3 +Thick hair 0.6347226989372592 0.8779481394076407 0.379971863124207 1.0 0.7522898615032981 5 Q9Y487 1 +Abnormality of adrenal physiology 0.4335264485160949 0.8761109661608284 0.3809697117498314 1.0 0.7532539271656256 28 Q9H0R6,P51809,Q13423,P38571,O00170,Q658P3 6 +Inguinal hernia 0.3873350294686758 0.8725355986463114 0.3829162565293242 1.0 0.7564263522238505 60 Q99519,Q9UHX1,Q15056,Q9NWM8,P08236,Q8NCH0,P16278 7 +Abnormality of chromosome stability 0.5168945228238251 0.8696331653208723 0.38450090726233 1.0 0.7585403714635528 10 P54132,P38398 2 +Low levels of vitamin d 0.5948960577768236 0.8689615825856193 0.3848681440722368 1.0 0.7585881467163561 7 Q10471 1 +Abnormal odontoid tissue morphology 0.4216293292807854 0.8685769526455968 0.385078565075855 1.0 0.7586602155556853 34 Q9UBM7,P16278 2 +Nephrolithiasis 0.4688220952351833 0.8577946351918794 0.3910058726468333 1.0 0.7669263745973142 17 Q15056,Q8NCH0 2 +Iron deficiency anemia 0.6370488378410949 0.8570273599090191 0.3914297641259643 1.0 0.767077468643837 4 Q10471 1 +Neuronal loss in the cerebral cortex 0.6282450069569027 0.8538790926822656 0.3931719849588639 1.0 0.7687143461016511 5 Q13501 1 +Pulmonary infiltrates 0.5908858416176346 0.8535313801505756 0.3933646934061046 1.0 0.7687143461016511 7 P04062,Q13510 2 +Abdominal obesity 0.6273626464188198 0.8506084008710854 0.3949869212195005 1.0 0.7696696937546111 5 P54132 1 +Aplasia hypoplasia of toe 0.4300192351126136 0.8469317427987503 0.397033168211137 1.0 0.7715575811339602 27 P55011,Q9UBM7,Q9UHX1,Q03164,Q13510 5 +Anorexia 0.4406787916037307 0.8466623291612695 0.3971833616297384 1.0 0.7715575811339602 22 P06280,P01889,Q13423,P04062,Q14108,P38398 6 +Chromosome breakage 0.5178523375550015 0.8466399724861361 0.3971958266270576 1.0 0.7715575811339602 9 P54132,P38398 2 +Abnormality of the testis size 0.4363019778148923 0.8461900161991215 0.3974467505786996 1.0 0.7715575811339602 23 Q9BZH6,Q06787,P27635,P51809,Q8IWS0,O43505,P38398 7 +Hand polydactyly 0.4404613033827488 0.8453789675769736 0.3978992836932726 1.0 0.7715575811339602 22 Q9BW83,Q9UBM7,Q9UHX1,Q9UM00,P54132,Q9Y263,Q14739 7 +Capillary malformation 0.504640027009071 0.843906474324335 0.3987216700390812 1.0 0.7715575811339602 11 Q15056,Q9UHX1 2 +Psychomotor retardation 0.4258224711428124 0.8432817722882439 0.3990708746101625 1.0 0.7715575811339602 30 O95831,Q99519,P04062,P16278 4 +Ectopic kidney 0.5043693964930667 0.8426962347775317 0.3993983535215482 1.0 0.7715575811339602 11 Q15056,Q9UHX1 2 +Vasculitis 0.5519314887918456 0.8425753560249317 0.3994659786139749 1.0 0.7715575811339602 8 O15143,P01889 2 +Paraparesis 0.4309497482856095 0.8419402791452217 0.3998213827626129 1.0 0.7715575811339602 24 Q13501,Q13510 2 +Ventricular arrhythmia 0.4279435437502304 0.8400019372429842 0.4009073003336216 1.0 0.7726418254359949 28 P10253,O43772,P42892 3 +Cerebellar atrophy 0.3559870078254309 0.8389684416432766 0.4014870190789148 1.0 0.7733085302078171 99 Q14108,Q8IV08,O14773,O75503 4 +Abnormal blood potassium concentration 0.5155308839751263 0.8367326050581871 0.4027428875028869 1.0 0.7733085302078171 9 Q13423 1 +Gray matter heterotopia 0.438305972797182 0.8326672235294243 0.4050324346843386 1.0 0.7755231422549045 22 O43505 1 +Tremor 0.3503720000144402 0.831181996450474 0.4058708237699504 1.0 0.7767921477864521 132 Q13501,Q99519,O75503,Q15056,O95831,O14773,P04062,O43464,Q14108,Q13510 10 +Iris coloboma 0.426280041573995 0.8230701396804904 0.4104681082797592 1.0 0.7800831687971966 27 Q9UBM7,Q96EK5,O43505 3 +Status epilepticus 0.4071527521692538 0.8228515221757312 0.4105924333949704 1.0 0.7800831687971966 37 P67870,Q15392,P42892,Q8NC96,Q01105,Q13510 6 +Gowers sign 0.5469265066439623 0.8223697731087971 0.4108664771753108 1.0 0.7800831687971966 8 Q13510 1 +Abnormal systemic blood pressure 0.3690329482787505 0.8219529908209161 0.4111036521052926 1.0 0.7800831687971966 72 O43772,P06280,Q15056,P07686,Q13423,P42892,P04062,P38571,O00170 9 +Disproportionate short limb short stature 0.4811673369215382 0.8204329211191698 0.4119693544613121 1.0 0.7803599378083012 14 Q15392,Q9UBM7,Q14739 3 +Gait imbalance 0.4489504892727265 0.8147435350886092 0.4152191279037682 1.0 0.7838302188298621 19 Q15056,O15269 2 +Abnormal shape of the frontal region 0.3677548703311758 0.8094977488976346 0.4182288971469958 1.0 0.7861573482181344 72 Q14738,Q99519,Q00577,P38398,Q06787,Q9Y487,P42345,Q9Y2U8,Q15392,O15160,Q14739,O00170,P16278,P15586 14 +Posteriorly rotated ears 0.3670842191565348 0.8079922994581904 0.4190950151150732 1.0 0.7861573482181344 78 Q9UBM7,Q9UHX1,P11233,Q15056,Q15392,P04062,P42892,Q9Y263,O43505,Q8NCH0 10 +Skeletal muscle atrophy 0.3474620901839381 0.8066706267542461 0.4198562713350013 1.0 0.7862517929267651 130 P35637,Q13126,O43505,P16278,Q99519,Q7Z392,P07686,O00170,O14979,Q13510,Q13501,Q14203,Q9Y2U8,O60568,O15269,Q9BW83,Q9Y2Z4,Q92804,Q9NWM8,P50402,Q7Z6Z7,Q14331,O95831,Q15165 24 +Platyspondyly 0.4245968014787614 0.8045933249897614 0.4210543952951882 1.0 0.7872116060909077 25 P08236,P16278,Q14739 3 +Abdominal distention 0.4706334261812601 0.802565545472237 0.4222258894540811 1.0 0.78828410981909 15 Q01844,P42345,P04062,P06737,P38571,P38398 6 +Decreased fertility in females 0.6137579416304645 0.8010409178663894 0.4231079580868806 1.0 0.7889572085237239 6 O00170,P54132 2 +Generalized onset motor seizure 0.3975034305490806 0.7979522508127419 0.4248981999564141 1.0 0.7906288339954647 39 Q99519,P67870,P04062,P16278,Q13510 5 +Large earlobe 0.5738951834384456 0.7885981245800544 0.4303469274192228 1.0 0.7969147465760309 7 Q15392,Q8IWS0,O60701 3 +Scarring 0.4221350367319945 0.7876525458231814 0.4308999700244755 1.0 0.7969147465760309 24 Q9NWM8,Q9Y2U8,O43395,Q92542,Q15555,Q8NCH0 6 +Insomnia 0.4743075247290736 0.787475557194427 0.4310035315168425 1.0 0.7969147465760309 14 Q15056,Q10471,O43464 3 +Abnormal nephron morphology 0.3889225938787926 0.7814611064406887 0.4345313434095934 1.0 0.7993626755033475 48 P06280,Q96AX1,Q14108,Q15056 4 +Abnormal size of the clitoris 0.4850202881940466 0.7807116535563123 0.4349721050029118 1.0 0.7993626755033475 12 Q9UBM7 1 +Eeg with generalized slow activity 0.5716640900745367 0.7801309310597891 0.4353138117679478 1.0 0.7993626755033475 7 O75503 1 +Facial hypertrichosis 0.388083574668816 0.7799126665326429 0.4354422822797339 1.0 0.7993626755033475 49 Q96AX1,Q96EK5,Q9Y2U8,P54802,Q03164,O60701,O00170,P15586 8 +Abnormal urine cytology 0.4065184968784068 0.7792729871339991 0.4358189235753753 1.0 0.7993626755033475 35 P06280,Q14108 2 +Muscle spasm 0.3879469229929464 0.7787989536787654 0.4360981541916295 1.0 0.7993626755033475 49 P35637,Q13501,P06280,Q7Z392,Q92804,P04062,O43464,Q15165 8 +Dysphonia 0.4183622004955256 0.7782322966351072 0.4364320802586443 1.0 0.7996433682617994 28 Q99519,Q13510 2 +Abnormality of the gallbladder 0.4180369245672302 0.7761406677110182 0.437665933899598 1.0 0.7996864286335817 28 P04062,Q9UBM7 2 +Abnormal circulating copper concentration 0.6146316442643014 0.7741225806100407 0.4388583053567929 1.0 0.7996864286335817 4 Q15904 1 +Increased circulating cortisol level 0.6175510204081596 0.7739137841544794 0.4389817776091904 1.0 0.7996864286335817 3 P17612,P04637 2 +Adrenal overactivity 0.6175510204081596 0.7739137841544794 0.4389817776091904 1.0 0.7996864286335817 3 P17612,P04637 2 +Aplasia hypoplasia of the palmar creases 0.6175494549784286 0.7739079839915747 0.4389852078333898 1.0 0.7996864286335817 3 Q8NCH0 1 +Amyotrophic lateral sclerosis 0.4575805745936012 0.7731062439658267 0.4394595061135433 1.0 0.7996864286335817 16 Q13501,P35637,Q15165,Q92804 4 +Fatigable weakness of swallowing muscles 0.4774795446260887 0.7728369098000111 0.4396189064660083 1.0 0.7996864286335817 13 Q13501,P35637,Q15165,Q92804 4 +Abnormal cellular phenotype 0.3536902626432672 0.7725458555221394 0.4397911987622434 1.0 0.7996864286335817 150 Q13501,O43772,Q15904,O75503,P02786,O14773,P04062,Q14108,Q13510,P15586 10 +Nausea and vomiting 0.3388962322864523 0.7724383486892127 0.4398548482343265 1.0 0.7996864286335817 119 Q13501,P35637,Q9P032,Q9UBM7,P06280,P11117,Q15056,P01889,Q92804,Q13423,P42892,O43464,P38571,O00170,Q15165,P38398 16 +Tongue fasciculations 0.4999837629991522 0.7707756706354234 0.4408399104269387 1.0 0.800096398776508 9 Q13510 1 +2 3 toe syndactyly 0.4340129769246497 0.7668251878762666 0.4431854585608161 1.0 0.8033644603338073 20 P11233,Q9UBM7,Q9UHX1 3 +Hallux valgus 0.4632016295588926 0.765964450663794 0.4436974548467418 1.0 0.8034109035660041 15 P04062 1 +Red eye 0.4453533424858035 0.7634703054321762 0.4451829650486512 1.0 0.8056645885475386 18 Q96AX1,P02786,Q14739 3 +Bulbar signs 0.4972420101670688 0.7592240829308349 0.447718522008659 1.0 0.8083457811840111 9 P04062,Q9Y263 2 +Hepatocellular adenoma 0.5467156262749907 0.7525986602745122 0.4516911229518632 1.0 0.8083457811840111 2 P10644 1 +Arterial stenosis 0.4838885895584077 0.7517036424853285 0.452229299439262 1.0 0.8083457811840111 11 Q15056 1 +Ragged red muscle fibers 0.4784824517259478 0.7510711706093476 0.4526098248195338 1.0 0.8083457811840111 12 Q9H2D1 1 +Centrocecal scotoma 0.5463076295389695 0.7508903350459034 0.4527186573986803 1.0 0.8083457811840111 2 O75306 1 +Diminished movement 0.4659544575778084 0.7475510426792188 0.4547310040745622 1.0 0.8103445733367401 14 O95831,P04062,Q14203 3 +Recurrent otitis media 0.4418702987287487 0.7449786802282812 0.456284608429603 1.0 0.8119065565344133 18 O14802,Q9UBM7,Q14739,Q06787 4 +Abnormality of vitamin d metabolism 0.5273882771231679 0.7441921115425494 0.4567602597090516 1.0 0.8119278823121863 8 Q10471 1 +Abnormal aortic valve physiology 0.4091948977074445 0.742937293911851 0.457519645480668 1.0 0.8119278823121863 31 Q15056,P04062,Q9UHX1,P16278 4 +Acquired abnormal hair pattern 0.5978791817045679 0.7425976331177779 0.457725321939904 1.0 0.8119278823121863 5 O60828,P54132,O75844 3 +Patchy alopecia 0.6088462780315131 0.741810047779893 0.4582024319511097 1.0 0.8119278823121863 3 P54132 1 +Abnormality of muscle size 0.3531607692342136 0.7413280939740706 0.4584945314723816 1.0 0.8119278823121863 155 P35637,Q13126,P10253,O43505,P16278,Q99519,Q7Z392,P07686,Q9Y487,O00170,O14979,Q13510,Q13501,Q96AX1,Q14203,Q9Y2U8,O60568,O15269,Q9BW83,Q9Y2Z4,Q15056,Q92804,Q9NWM8,P50402,Q7Z6Z7,Q14331,O95831,Q15165 28 +Abnormality of central nervous system electrophysiology 0.3316798431147804 0.740964753096615 0.4587148118292137 1.0 0.8119278823121863 111 Q13501,P55011,Q99519,O75179,Q9BQE5,O75503,Q9ULM3,Q8NC96,P50897,Q96C86,Q14108,Q9Y263 12 +Obsessive compulsive behavior 0.405104790827513 0.7388269921346605 0.4600120591991707 1.0 0.812237543265456 33 Q13501,O75503 2 +Limb girdle muscular dystrophy 0.5244567103686248 0.7325722358588427 0.4638193700138366 1.0 0.812237543265456 8 Q7Z392,O14979 2 +Abnormal esophagus morphology 0.397379880975784 0.7320365114452455 0.4641462828793559 1.0 0.812237543265456 36 P55011,Q15056,P01889,P04062,P54132,P38571 6 +Hypersplenism 0.5583081349140289 0.7297775775630508 0.4655261524254874 1.0 0.812237543265456 7 P38571,Q14108 2 +Abnormality of the sense of smell 0.4481921645328049 0.7257740480845093 0.4679772988857515 1.0 0.8137892733313 16 P04062,Q9BZH6,O43464 3 +Duplication involving bones of the feet 0.467237506965482 0.7253205279976501 0.4682554150188014 1.0 0.8137892733313 13 Q9UBM7,Q14739 2 +Abnormal renal cortex morphology 0.3837151187281395 0.7249017168759576 0.4685123275313105 1.0 0.8139159562729719 44 P06280 1 +Limitation of joint mobility 0.3585162083979804 0.7196426603566218 0.4717450387787252 1.0 0.8155842468824697 76 Q96AX1,O75844,Q15056,P01889,Q9Y2U8,P54802,P50402,O15460,P08236,O60568,O14979,P16278,P15586 13 +Delayed puberty 0.3817157664558061 0.7189453839542145 0.4721745717841805 1.0 0.8155842468824697 47 Q9Y2Z4,Q13045,Q9BZH6,O75844,P06280,P27635,O00170,P51809,Q9Y3E5,Q8IWS0,P04062,P06737,Q14108 13 +Wide nasal ridge 0.5993608838845805 0.7186301471397379 0.4723688332216691 1.0 0.8155842468824697 4 P27635 1 +Emg neuropathic changes 0.4313083992962959 0.7184168937829624 0.4725002733630019 1.0 0.8155842468824697 19 O14773 1 +Onset 0.334765379149761 0.7168398634766047 0.4734729115467877 1.0 0.815697452893705 318 O00584,Q9UHX1,P06280,Q8IV08,P61916,P50897,O43505,Q9Y263,P16278,P06865,Q5MNZ6,Q15904,P07686,O14773,O15118,Q9H4L7,Q9BUF5,P54802,P38571,O14979,Q13510,P55011,P04062,Q07021,P11233,Q96EK5,Q96C86,O95831 28 +Abnormal tricuspid valve physiology 0.4530115557523516 0.7161071344147658 0.4739251988043436 1.0 0.815697452893705 15 Q15904 1 +Tetraplegia 0.4812408252256389 0.7151583491939455 0.474511202426024 1.0 0.8160042956183142 10 O95831 1 +Impairment in personality functioning 0.3537963844325767 0.7140930719444575 0.4751696296805126 1.0 0.8165016597035382 163 P05067,O75503,P06280,P17900,Q8NC96,P50897,O00170,Q13501,P55011,P01889,P04062,Q03164,O43464,Q9BZH6,Q15056,Q92804,Q7Z6Z7,Q96C86,Q15165,O15460 20 +Polysplenia 0.5373317013463953 0.7135491400957221 0.4755060166918408 1.0 0.8167623735254416 2 Q86Y56 1 +Tetraplegia tetraparesis 0.3888828727607133 0.7101455014360931 0.477613912407264 1.0 0.8188567593890101 38 Q13501,P17900,O95831 3 +Cerebral cortical atrophy 0.357578512340652 0.7096641014875318 0.4779124585931629 1.0 0.8188567593890101 74 Q13501,P05067,O75503,Q15056,P04062,Q9Y263 6 +Hypoplasia of the brainstem 0.4171459725210653 0.7086824460825704 0.4785215605049815 1.0 0.8193963848678022 22 O43505 1 +Abnormality of the abdominal wall 0.3553620164234103 0.7077002436901136 0.4791314260569401 1.0 0.8201231801276494 84 Q99519,Q9UBM7,Q9UHX1,Q15056,Q9NWM8,P08236,Q8NCH0,P16278,Q14739 9 +Morphological abnormality of the corticospinal tract 0.4571173612343571 0.7056030479957626 0.4804350282496072 1.0 0.8217454228819869 14 Q13501,P35637,Q14203,Q15056 4 +Nail dysplasia 0.4082849548661925 0.7055777756052918 0.4804507491686227 1.0 0.8217454228819869 26 P42892 1 +Renal cortical microcysts 0.5344757241942051 0.7017695505985939 0.4828228909049836 1.0 0.8221657630468758 2 Q6PGP7 1 +Constipation 0.3565304455176923 0.6994116872445536 0.4842947860315687 1.0 0.8238599379298572 74 P55011,Q9UBM7,Q15056,Q13423,P42892,Q10471,P04062,Q03164,O43464,Q8NCH0 10 +Spina bifida occulta 0.4552230151695209 0.6966545489246756 0.4860190092987611 1.0 0.825206172026265 14 Q15056 1 +Coloboma 0.3944927772137306 0.6944599699920277 0.4873937962726997 1.0 0.8262716599900923 35 Q9UBM7,Q96EK5,O43505 3 +Abnormal aortic valve cusp morphology 0.426680509166403 0.6933619235441468 0.4880824512202244 1.0 0.8264548345352446 19 Q15056,Q9UHX1 2 +Abnormality of mouth size 0.3442493638034168 0.6933342734704508 0.4880997991165148 1.0 0.8264548345352446 98 Q9UBM7,Q15056,Q9Y487,Q15392,P04062,Q01105,Q96C86,Q8NCH0,P16278,P15586 10 +Pneumonia 0.3791964611998235 0.6895141381665923 0.4904997792404901 1.0 0.827423819413006 44 Q96AX1,O95721,P04062,P54132,Q7Z2Z2,P16278,Q13510 7 +Overlapping toe 0.4409476001694749 0.6895052498359369 0.4905053706762157 1.0 0.827423819413006 16 Q9UBM7,Q9UHX1,Q7Z6Z7 3 +Optic disc hypoplasia 0.5909177391726488 0.6883531058383319 0.4912304468695772 1.0 0.8278168550435394 4 O95721 1 +Pancreatic islet cell hyperplasia 0.5939379195485703 0.6875786695434389 0.4917181444522656 1.0 0.8278908842452877 3 Q14739 1 +Enlarged ovaries 0.5934693877550979 0.6858910120367709 0.4927818383831179 1.0 0.8288684399526387 3 P10644,P21912 2 +Bowing of the legs 0.387990133055884 0.683215056802502 0.494470959718553 1.0 0.8303132326633106 37 P08236,Q13126,P16278,Q15056 4 +Abnormal anterior chamber morphology 0.5890400011018194 0.6816623062862339 0.495452507289926 1.0 0.8310149562925078 4 Q8NCH0 1 +Metaphyseal dysplasia 0.5441617392924669 0.6771515803343304 0.4983097852205631 1.0 0.8340056583694986 7 O95831,Q7Z2Z2 2 +Fatigable weakness of respiratory muscles 0.4510121919444687 0.6768236201020861 0.4985178698558545 1.0 0.8340056583694986 14 Q13501,P35637,Q15165,Q92804 4 +Hyperhidrosis 0.4034932594441029 0.6757947761651597 0.4991709518046239 1.0 0.8340056583694986 26 P07686,O00170,Q9Y263,P01889 4 +Decreased circulating antibody level 0.3865764011601319 0.672989811677314 0.5009537726672064 1.0 0.8351747216385429 37 Q15904,P54132,P02786 3 +Fatigue 0.3528261209228686 0.6720022292007501 0.5015822771686469 1.0 0.8359074649272514 68 Q13501,P38398,Q07021,P06280,P01889,Q92804,Q13423,P04062,O15460,O00170,Q15165,Q14739,Q658P3 13 +Congenital malformation of the right heart 0.5775648872483541 0.6699459823093667 0.5028922257020212 1.0 0.8371563417193584 5 P01889 1 +Abnormal nerve conduction velocity 0.3947966246779596 0.6685056562027775 0.5038108726060144 1.0 0.8374846106334908 33 Q99519,O15269 2 +Abnormality of the clitoris 0.4361622830855426 0.6656879834212878 0.5056105558425488 1.0 0.8388280151881445 16 Q9UBM7 1 +Abnormal libido 0.5838612033338528 0.6632939959904633 0.5071422811210899 1.0 0.8394799062120437 4 O00170 1 +Vertigo 0.4120148533631232 0.6602442949076041 0.5090970711954013 1.0 0.8414560335938938 21 P06280,O00170,P01889 3 +Dyskinesia 0.3751644204204584 0.658049516038606 0.5105063139557791 1.0 0.8425259054576161 44 P67870,Q01105,P04062,Q8NC96,O43464,Q96C86 6 +Hand muscle weakness 0.4727025184192991 0.6571710818779134 0.5110709175807013 1.0 0.8427109400570009 9 Q13501,Q14203,Q15120 3 +Micromelia 0.4193637647070832 0.6539738787589393 0.5131286346887374 1.0 0.8427109400570009 19 Q15392,Q9UBM7,Q14739 3 +Premature ventricular contraction 0.5729739356139529 0.653769791420118 0.513260131485447 1.0 0.8427109400570009 5 O43772 1 +Inflammation of the large intestine 0.470640124963068 0.6487202077968612 0.5165192403377299 1.0 0.8457405987267715 9 O15143,P08183,P01889,Q13546 4 +Cutaneous melanoma 0.5214198286413704 0.6486052596002504 0.5165935550198861 1.0 0.8457405987267715 2 P11802 1 +Urinary incontinence 0.3948478658342831 0.6478823188044014 0.5170610674615799 1.0 0.8457405987267715 31 P35637,Q13501,P07686,Q10471 4 +Muscular dystrophy 0.4079671290390404 0.637448631270904 0.5238326599442842 1.0 0.8513230321096897 21 Q7Z392,P50402,O43505,Q14331,O14979 5 +Increased head circumference 0.3485426124684376 0.6374346083946444 0.5238417914696512 1.0 0.8513230321096897 84 Q99519,P07686,Q15392,O43505,P08236,Q14739 6 +Fatigable weakness of bulbar muscles 0.4425418302075593 0.6372050178046855 0.5239913096589637 1.0 0.8513230321096897 14 Q13501,P35637,Q15165,Q92804 4 +Abnormal renal pelvis morphology 0.3859695105774179 0.634846275882663 0.5255286787770099 1.0 0.8513230321096897 35 Q9UBM7,O43505 2 +Abnormality on pulmonary function testing 0.4292251702771485 0.631382061617965 0.5277907422003407 1.0 0.8516667102342601 16 Q7Z392,P01889,P16278 3 +Chronic fatigue 0.5663455321134794 0.6305901935826965 0.528308512465751 1.0 0.8521913022013189 5 Q13423 1 +Bifid uvula 0.3932536903539954 0.6295214417909418 0.5290077357665308 1.0 0.8528355783660119 30 O43505 1 +Mandibular prognathia 0.3954460665953443 0.6284169364128185 0.5297308450679448 1.0 0.8530361431878425 27 P67870,O00170,Q9UHX1,P16278 4 +Respiratory arrest 0.572742647858669 0.6243051273906245 0.5324272172444549 1.0 0.8530361431878425 4 O43772 1 +Tetraparesis 0.3933688339340189 0.6239063789959927 0.5326890707676939 1.0 0.8530361431878425 29 P17900 1 +Hypertrichosis 0.3470774441256153 0.6223910063986815 0.5336847927344261 1.0 0.8530361431878425 84 Q96AX1,Q99519,Q9UHX1,Q96EK5,P54802,P54132,Q03164,O00170,P16278,P15586 10 +Abnormality of skeletal maturation 0.3486128071671256 0.6222398931282659 0.5337841378772314 1.0 0.8530361431878425 74 Q99519,O75179,Q9BZH6,Q15056,O95831,P51809,O00170,P04062,Q03164,Q7Z2Z2,Q14108 11 +Cardiac arrest 0.3947688177462032 0.6219194548500409 0.5339948318600838 1.0 0.8530361431878425 26 O43772,Q14126,Q15056,P01889,P04062 5 +Inability to walk 0.3483342199502025 0.6202415411244929 0.5350987759180974 1.0 0.8538029891362716 73 P35637,Q96AX1,Q99519,Q5MNZ6,O75503,Q7Z392,Q9UID3,Q96C86,O15269,Q13510 10 +Abnormal circulating monocarboxylic acid cocentration 0.5281588096658708 0.6186601233395437 0.5361402849912316 1.0 0.8547421445408282 7 Q9UDY2,Q7Z2Z2 2 +Abnormal mitochondrial morphology 0.4951659796556145 0.6184676510358955 0.5362671153291427 1.0 0.8547421445408282 8 Q13501 1 +Malabsorption 0.3697131472824007 0.6177732773169311 0.5367248009341006 1.0 0.8548555255785116 45 P06280,Q15056,P01889,P38571,Q14739 5 +Macular atrophy 0.5615282148098768 0.6167786872001618 0.5373807115425477 1.0 0.8550515053922488 6 P04062 1 +Abnormal middle phalanx morphology of the hand 0.5269852988167304 0.6144196483121505 0.5389380552540899 1.0 0.8568378930225878 7 Q8IWS0,Q03164,Q9UHX1 3 +Recurrent bacterial infections 0.4374136397118852 0.6134135972091522 0.5396028976133467 1.0 0.8572785977528132 14 Q15904 1 +Abnormal upper motor neuron morphology 0.4562195290812014 0.6097622962876981 0.542019280899112 1.0 0.8591337594535567 10 Q13501 1 +Foot dorsiflexor weakness 0.3925560773254833 0.6075078748770839 0.5435139181557584 1.0 0.8597279305033103 25 Q13501,O15269 2 +Abnormal circulating glutamine concentration 0.510403916768665 0.604709614227511 0.5453719588891883 1.0 0.8605708791176881 2 Q9UJS0 1 +Cardiac valve calcification 0.5659566020005602 0.600831021120797 0.5479525402491463 1.0 0.8611541708572142 4 P04062 1 +Mitral valve calcification 0.5659566020005602 0.600831021120797 0.5479525402491463 1.0 0.8611541708572142 4 P04062 1 +Abnormal neuron morphology 0.3909846007167256 0.6007005149961542 0.5480394759739853 1.0 0.8611541708572142 27 P35637,Q13501,Q92804,Q15165,Q13510 5 +Gonosomal inheritance 0.3620638629813104 0.596434637798793 0.5508849066107362 1.0 0.8618752156852435 54 Q15904,P51571,Q06787,P06280,P27635,Q8IWS0,P50402,Q7Z6Z7,O95831,Q15120,O00571 11 +Poor speech 0.3522708225497876 0.5959235740081417 0.5512262839029867 1.0 0.8618752156852435 63 Q13501,O00584,P67870,Q9Y487,Q01105,P08236,Q96C86 7 +Pulmonary artery stenosis 0.4570369923207216 0.593564397273578 0.552803499497033 1.0 0.8627557792079664 9 Q15056,P27635 2 +Scapular winging 0.4076313217544698 0.5914860971761915 0.5541947677522496 1.0 0.8640124983321115 19 Q13501,Q9Y487,P50402 3 +Abnormal carotid artery morphology 0.4422741006451524 0.5902698996833609 0.555009716042705 1.0 0.8642911151117717 12 Q15056,P38398 2 +Decreased methylcobalamin 0.506323949408412 0.5886972967402295 0.5560643516337387 1.0 0.8651575533222966 2 P11586 1 +Abnormal larynx morphology 0.398771027444053 0.5860594893005621 0.5578355384259654 1.0 0.8654257300170742 21 Q14739,Q9UHX1,Q13510 3 +Irregular menstruation 0.5524386943918489 0.582689091282954 0.5601026181171238 1.0 0.867972800087642 5 O00170 1 +Abnormality of skeletal muscle fiber size 0.4249168247122497 0.5812792245876995 0.5610522802284803 1.0 0.867972800087642 15 Q13501 1 +Female hypogonadism 0.551878265595809 0.5807808996045685 0.5613881297190018 1.0 0.8681887055059947 5 O00170,Q9BZH6 2 +Abnormal respiratory system morphology 0.3521052610179575 0.5799403352533427 0.5619548540051511 1.0 0.8685957238836094 242 P35637,Q9UHX1,P06280,Q01844,P02786,P10253,P54132,Q14108,P16278,P15586,Q00577,Q99519,Q06787,Q9UID3,Q9Y487,P54802,Q13510,Q13501,P55011,Q96AX1,Q9UBM7,P01889,Q15392,P04062,Q03519,Q7Z2Z2,P08236,Q14739,P38398,O95721,Q15056,Q92804,Q7Z6Z7,Q15165,Q8NCH0,O15460 36 +Decreased muscle mass 0.4294104792860404 0.5766119431526301 0.5642016293951919 1.0 0.8707131217079322 14 Q8NCH0 1 +Abnormality of salivation 0.3729677812048882 0.5753206713575062 0.5650744437722843 1.0 0.8712325200868205 37 Q13501,P55011,P01889,Q92804,Q15165,P15586,Q14739 7 +Dilation of lateral ventricles 0.404267127371011 0.5737432298428948 0.5661415700746415 1.0 0.8722233837210168 19 Q14738,Q9UID3,P67870,Q01105,Q92947 5 +Abnormal circulating protein concentration 0.3241159436428872 0.5721203478850787 0.5672404448352317 1.0 0.8732699225569891 121 Q13501,Q96AX1,O43772,Q9H0R6,Q07021,Q14126,Q15056,Q9Y487,Q9NWM8,P10253,O43505,O95831,O14979,Q658P3 14 +Osteomyelitis 0.4420203173459774 0.5710246646994674 0.5679829237036271 1.0 0.873392447686571 11 Q13126,O15269 2 +Abnormality of the metaphysis 0.3767217758662469 0.5707829054178968 0.5681468120869582 1.0 0.873392447686571 35 Q13126,Q96AX1,Q7Z2Z2,O95831,P16278,Q14739 6 +Facial edema 0.3861978605477583 0.5695170804470128 0.5690052826874741 1.0 0.873392447686571 26 Q99519,Q15056,Q9NQW6,Q8NFH4,Q14331,O00170 6 +Increased blood pressure 0.3551826873122959 0.5694457623845783 0.5690536683590444 1.0 0.873392447686571 58 P06280,P38571,P04062,P42892 4 +Abnormality of the shoulder girdle musculature 0.3856626905124387 0.5668092786063035 0.5708437659503667 1.0 0.8739501477322504 24 Q13501,O14979,Q9Y487,P50402 4 +Eclabion 0.3853674646740009 0.5660246676138082 0.5713770118032251 1.0 0.8744085467588641 27 Q15056,P04062 2 +Wide intermamillary distance 0.4152052085350832 0.5629745861115858 0.5734521894879085 1.0 0.8753474132667041 16 Q9BZH6,Q9UBM7,Q96EK5,Q9UM00,Q15555,Q5SRE5 6 +Acute hepatic failure 0.4356426375423173 0.5616110380789304 0.5743810582122368 1.0 0.8753474132667041 12 P16930,P38571,Q6NUQ1,P01889 4 +Abnormal nervous system electrophysiology 0.3330125888310455 0.5614450181975152 0.5744942019846371 1.0 0.8753474132667041 140 Q13501,P55011,Q99519,O75179,Q9BQE5,O75503,O95721,Q9ULM3,O95831,O14773,Q5SRE5,Q8NC96,P50897,Q9Y263,Q96C86,Q14108,O15269 17 +Male hypogonadism 0.5118766748839441 0.5604905731987174 0.5751448678233877 1.0 0.8753839471379367 7 O00170 1 +Generalized hypopigmentation 0.4781913782286427 0.5543728647571387 0.5793236927984713 1.0 0.8790218501707164 8 Q9Y2U8,O14617 2 +Increased susceptibility to fractures 0.3614616117617449 0.5509731721405599 0.5816520654735617 1.0 0.8799596386063957 43 Q13501,P04062,Q14108,O15269,Q14739 5 +Abnormal location of ears 0.3463284106577382 0.5499857359107316 0.5823291571785938 1.0 0.8799596386063957 181 Q9UHX1,P42892,O43505,Q9Y263,P16278,P15586,Q99519,Q9Y487,Q10471,P55011,Q9UBM7,Q15392,P04062,Q03164,Q7Z2Z2,Q14739,P11233,Q15056,Q96EK5,Q96C86,O95831,Q8NCH0 22 +Sparse lateral eyebrow 0.550744593226889 0.549190633494042 0.5828746316332616 1.0 0.8801824840266016 4 Q00577 1 +Abnormal morphology of the limbic system 0.4766247250119272 0.5485468509177707 0.5833164687242958 1.0 0.880248632264606 8 Q01105,Q9UID3,P67870 3 +Abnormal facial shape 0.3504120281984517 0.5478474715979809 0.5837966395007879 1.0 0.8806727614297356 237 O00584,Q9UHX1,P06280,P54132,Q9Y263,P16278,P15586,Q99519,P07686,P10619,Q9Y487,Q10471,P54802,O00170,Q13510,P55011,Q96AX1,P04062,Q03164,P08236,P38398,O75179,Q15056,P67870,Q01105,Q96C86,O95831,Q8NCH0 28 +Nonprogressive 0.5406284968477488 0.5464014217739713 0.5847900330060773 1.0 0.8813325668762974 6 Q9BUF5 1 +Cutaneous syndactyly 0.47603032153439 0.5463406373430946 0.5848318073212599 1.0 0.8813325668762974 8 Q9Y2U8,P27635,Q9H4L7,P98175 4 +Scleroderma 0.5412304169111021 0.5448780035478943 0.5858374256444825 1.0 0.881646455809985 5 Q14739 1 +Abnormality of the bladder 0.3372161247747343 0.5429639446752111 0.5871546273658561 1.0 0.8817547955434578 89 Q13501,Q9UHX1,Q15056,P07686,Q9NWM8,P04062,Q10471,O00170,Q8NCH0 9 +Infertility 0.4311409115662988 0.5423286810089187 0.587592100921746 1.0 0.8817547955434578 12 P51809,P54132 2 +Degeneration of the lateral corticospinal tracts 0.5393065118364666 0.5420310038197823 0.5877971478344495 1.0 0.8817547955434578 6 Q13501,P35637 2 +Arterial thrombosis 0.5391000639748004 0.5413494284125314 0.5882667572800788 1.0 0.8817547955434578 6 P01889 1 +Reduced tendon reflexes 0.3249305662541021 0.5410094738080538 0.5885010527796264 1.0 0.8817547955434578 127 P35637,Q14738,Q13045,P61981,P10253,Q8NC96,O43505,Q9Y3B2,Q05639,Q06787,Q7Z392,Q9Y3E5,Q13217,P54802,O14979,Q13510,Q13501,Q96AX1,P04062,P51114,O15269,O95721,P35251,O60701,P50402,O95831 26 +Easy fatigability 0.4061062107201061 0.5374298288718004 0.5909707435982638 1.0 0.8834679876414943 17 Q9NWM8 1 +Night sweats 0.4916360669114666 0.5322597986616635 0.5945460715142008 1.0 0.8863084847682204 2 Q9UJS0 1 +Schizophrenia 0.4186909169368212 0.5280219450168762 0.597484104669221 1.0 0.8866288798952635 14 P04062 1 +Impairment of activities of daily living 0.3611334561705728 0.5269101054965741 0.5982560158977019 1.0 0.8866288798952635 39 P35637,Q13501,P07686,Q10471,O15269 5 +Palpebral edema 0.5430501356617536 0.5236325097902413 0.6005341653898648 1.0 0.8885938766932436 4 O00170 1 +Coma 0.377295263680263 0.5223646707433539 0.601416449415147 1.0 0.8885938766932436 29 P05067,O43772 2 +Joint contracture of the hand 0.3753339679313262 0.5209386999196881 0.6024094750564646 1.0 0.8885938766932436 31 O75844,P27635,Q9H4L7,Q9Y3E5,Q15392,P42892,O14802 7 +Bifid scrotum 0.5339632692968798 0.520779112304915 0.6025206555253506 1.0 0.8885938766932436 5 Q9UBM7 1 +Branchial anomaly 0.5004225351606963 0.5205088841647182 0.6027089373908503 1.0 0.8885938766932436 7 O15160,Q9UHX1 2 +Abnormality of vitamin k metabolism 0.541713741221136 0.5192346459716533 0.603597121503276 1.0 0.8894135472157184 4 Q7Z2Z2 1 +Orthostatic hypotension due to autonomic dysfunction 0.4993420131959754 0.51678106754542 0.6053089976571491 1.0 0.8906459403318597 7 Q04637,P04062 2 +Multifocal epileptiform discharges 0.3932531523324281 0.5162895596700291 0.605652186973463 1.0 0.8908545470514223 19 Q96C86,O75503 2 +Abnormality of urine homeostasis 0.3375537688238696 0.5155227118339474 0.6061878029551322 1.0 0.8910776222271203 160 Q99519,O43772,P06280,Q15056,P10253,P04062,P54802,P08236,Q14108,P16278,P15586 11 +Emg abnormality 0.3505974915245402 0.5149188845204057 0.6066097039398279 1.0 0.8910776222271203 56 Q13501,Q14126,O14773,Q13510 4 +Abnormal meningeal morphology 0.410314222286481 0.5132380415279152 0.6077848185418597 1.0 0.8921762240241201 15 Q15904,Q9UHX1 2 +Aplasia hypoplasia affecting the eye 0.3369942915198918 0.5114400323821221 0.6090429692190569 1.0 0.8928353013112622 73 Q99519,Q9UBM7,Q9UHX1,Q9BZH6,Q15056,O43505,Q5SRE5,P38398 8 +Large basal ganglia 0.4238007133151341 0.5112119207489894 0.6092026723478519 1.0 0.8928353013112622 12 Q96C86 1 +Typical absence seizure 0.4316133000908752 0.5097188106147625 0.6102484726344197 1.0 0.8928353013112622 10 P67870,Q13510 2 +Very long chain fatty acid accumulation 0.4855161158710801 0.5093450512281091 0.6105103848749687 1.0 0.8928353013112622 2 O75381 1 +Motor regression 0.4855161158710729 0.5093450512280832 0.6105103848749869 1.0 0.8928353013112622 2 P11766 1 +Profound global developmental delay 0.4351533679752027 0.507322105360656 0.6119288307339894 1.0 0.8928353013112622 9 P55011,Q9Y4R8 2 +Upper limb spasticity 0.5286058808050904 0.5070464781482867 0.6121222074078729 1.0 0.8928353013112622 6 P35637 1 +Aplasia hypoplasia of the radius 0.4184781750704156 0.5064508814242458 0.6125401630571408 1.0 0.8928353013112622 13 Q9UBM7 1 +Short nail 0.5370223180849666 0.5038958836972808 0.6143345433212446 1.0 0.8935224219368184 4 Q9Y487 1 +Abnormal leukocyte count 0.3338411840480581 0.5026906963467036 0.6151817518369049 1.0 0.8941665752134835 88 Q96AX1,Q15904,P02786,O15143,P04062,P54132,O43464,P38571,Q7Z2Z2,Q14108,Q14739 11 +Blue sclerae 0.398711314243168 0.501285064007056 0.6161705153780248 1.0 0.894588550858841 17 Q96EK5,P62266,O14802,Q8NCH0,Q9Y3B2 5 +Ventriculomegaly 0.3284709898756031 0.4980689070862876 0.6184354749798375 1.0 0.8961945197222855 141 O00584,Q9UHX1,O43505,Q9Y263,P16278,Q5MNZ6,Q9Y487,Q9UBM7,Q15392,P04062,O43464,Q5SRE5,P38398,P67870,Q96EK5,Q01105,O60701,Q7Z6Z7,Q8NCH0 19 +Juvenile aseptic necrosis 0.5351538125744066 0.4978309762931756 0.6186031808076278 1.0 0.8961945197222855 4 Q8IWS0 1 +Corneal ulceration 0.5253918260155418 0.492809422188979 0.6221472525393836 1.0 0.8980792974159845 5 Q96EK5 1 +Ventricular tachycardia 0.4311710936698636 0.4920112730586961 0.622711374297886 1.0 0.8980792974159845 9 O43772 1 +Abnormal lung lobation 0.4227592163132981 0.4914712007823929 0.6230932162907168 1.0 0.8980792974159845 11 Q9UBM7,Q14739 2 +Panhypopituitarism 0.48062015503876 0.4912871159456602 0.6232233911513185 1.0 0.8980792974159845 2 Q8N3U4 1 +Abnormal dura mater morphology 0.48062015503876 0.4912871159456602 0.6232233911513185 1.0 0.8980792974159845 2 Q8N3U4 1 +Median cleft lip 0.48062015503876 0.4912871159456602 0.6232233911513185 1.0 0.8980792974159845 2 Q8N3U4 1 +Cyclopia 0.48062015503876 0.4912871159456602 0.6232233911513185 1.0 0.8980792974159845 2 Q8N3U4 1 +Tongue thrusting 0.4806201550387597 0.4912871159456599 0.6232233911513188 1.0 0.8980792974159845 2 P51608 1 +Hand apraxia 0.4806201550387597 0.4912871159456599 0.6232233911513188 1.0 0.8980792974159845 2 P51608 1 +Abdominal aortic aneurysm 0.5327670314368906 0.4901213210129125 0.6240480516363693 1.0 0.8981599275757592 4 P01889 1 +Muscle fibrillation 0.4138887175893592 0.4866986549831896 0.6264718985353794 1.0 0.8985050027010725 13 Q13510 1 +Basal ganglia calcification 0.5222721700040925 0.4866844832533002 0.6264819430174196 1.0 0.8985050027010725 6 Q969U7,O00429,Q9Y3Z3,O60313,P00403 5 +Abnormal blood transition element cation concentration 0.4211344997587054 0.4848932456330087 0.6277520738637012 1.0 0.8986111141292445 11 Q15904,Q658P3 2 +Aplasia hypoplasia of the spleen 0.5346938775510156 0.4844113238998487 0.6280939834870467 1.0 0.8986111141292445 3 Q86Y56,P08865 2 +Abnormal delivery 0.3912162623613388 0.4838085751470521 0.6285217287601144 1.0 0.8987881042049745 18 Q7LBC6,Q9Y487,Q9UBM7,O75844 4 +Focal segmental glomerulosclerosis 0.3868699241652067 0.483489763856384 0.6287480260885068 1.0 0.8988211116320186 19 Q96AX1,Q14108,Q9NQW6 3 +Prenatal maternal abnormality 0.4232376447932941 0.4766938561036546 0.6335801384959903 1.0 0.8990455414076884 10 O43772 1 +Abnormality of the posterior pituitary 0.4868197938336731 0.4741738976164408 0.6353759054174679 1.0 0.9004382023907275 7 Q9UHX1 1 +Abnormality of upper limb joint 0.332766590107888 0.4721504513611002 0.6368194035378614 1.0 0.9010147600342162 82 Q15056,Q9H4L7,Q15392,P42892,O95831,P16278,Q13510 7 +Thick eyebrow 0.3529145560459252 0.46736429018605 0.6402392668227188 1.0 0.9035667763742454 39 Q9UHX1,Q96EK5,P08236,O95831,P15586 5 +Primary adrenal insufficiency 0.4206569425287111 0.4666381257381082 0.6407588048811288 1.0 0.9040115451321316 10 Q13423 1 +Abnormal thrombocyte morphology 0.3189829559662709 0.462942073805317 0.6434058884329172 1.0 0.9051455951099198 103 Q96AX1,Q15904,P02786,P01889,O15143,P04062,Q7Z2Z2,P38571,Q14108,Q14739,Q13510 11 +Progressive microcephaly 0.365052974504903 0.4620970670177982 0.6440117133976984 1.0 0.9051455951099198 32 P50897,Q9Y263,Q9Y487 3 +Periventricular heterotopia 0.4232316708641942 0.4618827755945927 0.6441653865841395 1.0 0.9051455951099198 9 Q9UBM7 1 +Abnormal uvula morphology 0.3637683512924403 0.4617785352877361 0.6442401451460567 1.0 0.9051455951099198 33 O43505 1 +Abscess 0.4817894673270715 0.4573834795959046 0.6473954365805399 1.0 0.9069392899600076 7 P54132,P38398 2 +Abnormal choroid morphology 0.385815566065976 0.4571682158073545 0.6475501419158272 1.0 0.9069392899600076 18 O43505 1 +Abnormal chorioretinal morphology 0.385815566065976 0.4571682158073545 0.6475501419158272 1.0 0.9069392899600076 18 O43505 1 +Gastrostomy tube feeding in infancy 0.3671452674792891 0.4554383525628688 0.6487939087706405 1.0 0.9075317705542514 26 Q01105,O60701,P67870,P54132 4 +Abnormal platelet granules 0.4696042431660622 0.451601800112769 0.6515558729733546 1.0 0.9085219502399582 2 Q86YV9 1 +Poor head control 0.343465904879595 0.4440412850690187 0.6570127354773263 1.0 0.911146177277626 54 P06865,Q9P032,Q9NWM8,P17900,Q8NC96 5 +Pain 0.3245904138601477 0.443375726778721 0.6574939899772956 1.0 0.911146177277626 142 P35637,P06280,Q01844,Q13423,P42892,Q14108,Q06787,Q7Z392,P07686,Q9NQW6,O00170,Q13510,Q13501,O75844,Q14203,P01889,Q9Y2U8,P04062,O15269,P38398,Q14739,Q15056,Q92804,Q15165,O15460 25 +Poor suck 0.3700365467757266 0.4424329953697676 0.6581759069414459 1.0 0.911146177277626 22 Q9UBM7,O43464 2 +Shawl scrotum 0.5173530682491535 0.4413962368149017 0.6589261661048664 1.0 0.9113093845995 4 Q9UM00 1 +Abnormal venous morphology 0.3784991320717803 0.441108434058546 0.6591344979472638 1.0 0.9113093845995 19 Q92990,Q6ZRS2,O14802,Q9Y487,P98175,P04062,Q7LBC6 7 +Short nose 0.3299178618206928 0.440840861450145 0.6593282095148574 1.0 0.9113093845995 76 Q14738,Q9UHX1,P42892,Q9Y263,Q00577,Q9Y487,Q96AX1,O75844,Q9UM00,Q15392,P04062,Q03164,O60568,Q9Y2Z4,Q15056,P42345,Q7Z6Z7,Q96C86,Q8NCH0 19 +Decreased fertility 0.3717087476227265 0.4390018124453424 0.660660223052085 1.0 0.9113093845995 21 P51809,O00170,P54132,P38398 4 +Abnormality of the fetal cardiovascular system 0.4659322725418284 0.4386792922900688 0.6608939336899691 1.0 0.9113093845995 2 P16435 1 +Tibial torsion 0.4659322725418173 0.4386792922900296 0.6608939336899975 1.0 0.9113093845995 2 Q9Y5S9 1 +Irregular epiphyses 0.5191836734693828 0.4354135090580412 0.663262306475457 1.0 0.9116575045196166 3 Q9NR45,Q14807 2 +Patent ductus arteriosus 0.3281609597989454 0.4350969069950136 0.6634920884125357 1.0 0.9116575045196166 70 Q96AX1,Q9UBM7,Q9UHX1,Q15056,Q9NWM8,Q15392,P42892 7 +Generalized hyperpigmentation 0.4084529435886985 0.4343537217873315 0.6640315981658444 1.0 0.9121154530085498 11 Q13423,O00170 2 +Nausea 0.3921269750935592 0.431092103633022 0.6664014019638971 1.0 0.914030257536189 15 P06280 1 +Abnormal pleura morphology 0.3799781686368344 0.4287252591249198 0.6681231763118525 1.0 0.9145462730452562 18 P01889,P08236,Q8NCH0,O15460,Q14739 5 +Bradykinesia 0.3748492533629599 0.4228742567080258 0.6723870060777952 1.0 0.9184582235583968 19 Q04637,Q06787,Q14203,P04062,O43464,Q96IX5 6 +Abnormal circulating glutamine family amino acid concentration 0.5108207431604694 0.4213363759702106 0.6735094713943011 1.0 0.9196995069881448 4 P20674,P40925,Q9UJS0 3 +Retinopathy 0.365691730553663 0.4189494497204376 0.6752530764980693 1.0 0.9202438508588596 22 Q99519,P54132 2 +Abnormality of pain sensation 0.3655973908348585 0.4184421734292828 0.6756238574103819 1.0 0.9203216265248289 22 O95831,O15269 2 +Oral ulcer 0.4689592113359755 0.4154769279221166 0.6777928016898285 1.0 0.9226430588223806 7 P01889,Q7Z2Z2 2 +Abnormality of female external genitalia 0.3599975931266389 0.4133173981442716 0.6793740845977305 1.0 0.9226430588223806 27 Q15392,Q9UBM7 2 +Male infertility 0.4999648782059496 0.4130643005080044 0.6795595040623053 1.0 0.9226430588223806 5 P54132 1 +Abnormal tracheal morphology 0.3587989937522335 0.4119882407615554 0.680348042309074 1.0 0.9226430588223806 30 P55011,Q15056,Q9UBM7,Q14739 4 +Atrophy degeneration affecting the central nervous system 0.3413452684236592 0.4107808076681899 0.68123326740494 1.0 0.9230480274062184 226 P05067,Q9UHX1,O75503,P17900,Q8NC96,P50897,P16278,O14773,O15118,Q13510,Q13501,P04062,P08236,Q15056,P67870,Q01105,O43464,Q96C86,O95831 19 +Uveitis 0.4673764222515925 0.4104034648434522 0.6815100050188097 1.0 0.9230480274062184 7 P54132 1 +Abnormal erythrocyte sedimentation rate 0.4673421008424305 0.4102936942542048 0.6815905171848766 1.0 0.9230480274062184 7 O15143,P01889 2 +Exodeviation 0.3824007651748051 0.4093027039721926 0.6823175314209948 1.0 0.9237497525176186 16 Q9UHX1,Q7Z392,P27635,Q9Y3E5,Q10471,P55795,P82930 7 +Arthralgia 0.3581468827171462 0.404926962567343 0.6855311985968906 1.0 0.9248074299715092 29 P06280,Q15056,P01889,O00170,Q13510 5 +Myopathy 0.325817120787245 0.4008730626214467 0.6885135833436138 1.0 0.9264665589074548 78 Q13501,Q13126,Q9P032,Q9Y2Z4,Q07021,Q7Z392,Q14126,Q15056,O43676,Q9NWM8,P51114,O14979,Q8NCH0 13 +Abnormality of circulating glucocorticoid level 0.4032501619726204 0.4004405938429499 0.688832030271322 1.0 0.9266131599422316 10 Q13423 1 +Male reproductive system neoplasm 0.3994311219772822 0.3993422670837772 0.6896410272640028 1.0 0.9274193565182988 11 Q13423,P51809,P38398 3 +Retinal hemorrhage 0.493588870110759 0.3981007272991874 0.6905559382954849 1.0 0.9280182247087556 6 Q9Y487 1 +Visual impairment 0.340336492972789 0.3975355611027229 0.6909725684210553 1.0 0.9280182247087556 221 Q9UHX1,O75503,P17900,P50897,O43505,P16278,P06865,Q99519,Q5MNZ6,P07686,O14773,O00170,P55011,P01889,P38398,Q9P032,Q9BZH6,Q07021,Q15056,P67870,Q01105,Q7Z6Z7,Q96C86,O95831 24 +Hypoketotic hypoglycemia 0.4633013870332104 0.397443368432804 0.6910405400458184 1.0 0.9280182247087556 7 O43772 1 +Tachycardia 0.3696778212812804 0.3973146632327073 0.6911354357202444 1.0 0.9280182247087556 19 O43772,P42892 2 +Abnormality of the tonsils 0.4931829102764409 0.39689351786818 0.6914459844627547 1.0 0.9281534413592608 6 P31751,P54132 2 +Renal hypoplasia 0.3590090896076656 0.3963577309264353 0.6918411438832286 1.0 0.9282155440232112 23 Q15056,Q9UBM7 2 +Elevated lactate pyruvate ratio 0.5057142857142819 0.394605563921521 0.6931340066816658 1.0 0.9286886897419468 3 P53597,P09001 2 +Recurrent viral infections 0.4015857572335551 0.3942704053675592 0.6933814104512896 1.0 0.9286886897419468 10 P54132 1 +Abnormality iris morphology 0.3333390957821213 0.3932381970305094 0.6941435602995711 1.0 0.9289262939674862 59 Q15056,Q9UBM7,Q96EK5,O43505 4 +Hand oligodactyly 0.4524683802529583 0.3926987455108229 0.6945419973209308 1.0 0.9289262939674862 2 Q6KC79 1 +Lissencephaly 0.3399763448474512 0.3905007546895537 0.6961662973551541 1.0 0.9296930957735045 43 Q15392,Q9Y487,Q96EK5,O43505 4 +Dilated third ventricle 0.451244390044881 0.388632652999289 0.6975479083308491 1.0 0.929722353809994 2 P26358 1 +Abnormal urinary electrolyte concentration 0.3865381129912406 0.3883484154943567 0.6977582128077278 1.0 0.929722353809994 14 Q15056 1 +Pulmonary edema 0.4508363933088563 0.3872816517774239 0.698547707521114 1.0 0.929722353809994 2 Q14315 1 +Steppage gait 0.3745467200146801 0.386992213870118 0.6987619721711738 1.0 0.929722353809994 17 Q13501 1 +Abnormality of pancreas physiology 0.3519481630773636 0.3859260541069697 0.6995514342029527 1.0 0.929722353809994 33 Q15904,Q9UHX1,P01889,Q7Z2Z2,Q14739 5 +Disproportionate tall stature 0.3535313197859746 0.3814780045522439 0.7028485893449172 1.0 0.9318643017603624 24 P55011,Q8NCH0,Q15334,Q9NWM8 4 +Protruding ear 0.3448956327592556 0.380162307080868 0.7038249370621632 1.0 0.9322563061097556 37 Q15056,O43505,P54132,Q7Z6Z7,Q8NCH0 5 +Abnormality of the synovia 0.3277321497823782 0.3800561861147018 0.7039037082080593 1.0 0.9322563061097556 63 P55011,Q96AX1,Q9UBM7,Q9UHX1,Q9Y487,P08236,P16278,P38398 8 +Lateral clavicle hook 0.4483884128926964 0.3792218548720633 0.7045231236678475 1.0 0.9322563061097556 2 Q9Y5S9 1 +Aplastic clavicle 0.4483884128926952 0.3792218548720597 0.7045231236678502 1.0 0.9322563061097556 2 P48651 1 +Hernia 0.3135003674639876 0.3789962569853561 0.7046906433683926 1.0 0.9322563061097556 101 Q96AX1,Q99519,Q9UBM7,Q9UHX1,Q15056,Q9Y487,Q9NWM8,P08236,Q8NCH0,P16278,Q14739 11 +Short femur 0.4883071988064428 0.3783049429953701 0.70520407383619 1.0 0.9322563061097556 5 Q9UHX1 1 +Neoplasm of fatty tissue 0.4878856448676588 0.3770710769423216 0.7061207847112281 1.0 0.9322563061097556 5 Q9Y2U8 1 +Vomiting 0.3232498203757692 0.3768220215414379 0.706305874242322 1.0 0.9322563061097556 77 P06280,P11117,P38571 3 +Vestibular dysfunction 0.3525862542820626 0.3762230219304214 0.7067511015602597 1.0 0.9322875401732862 24 P06280,O00170,P01889 3 +Decreased circulating cortisol level 0.4562223902271343 0.3752900310076372 0.7074447793718988 1.0 0.9326881163406598 7 Q13423 1 +Ecchymosis 0.3901258656968182 0.3746357776500689 0.7079313610202225 1.0 0.9330096572683088 12 P04062,Q8NCH0 2 +Facial asymmetry 0.352080368665501 0.3673204523399152 0.7133799999983912 1.0 0.935532331297439 27 Q14738,Q9UHX1,Q01105,Q03164,Q8NCH0,P38398 6 +Unsteady gait 0.3364913798813654 0.3666978807339003 0.7138443875391067 1.0 0.9356307848173174 41 Q96C86,O95831,O75503 3 +Striae distensae 0.3969809114408832 0.3665346880339875 0.7139661335025582 1.0 0.9356307848173174 9 O00170 1 +Abnormal prostate morphology 0.4835874483249393 0.3645855951944897 0.715420769150483 1.0 0.936739509162992 5 P38398 1 +Abnormal circulating androgen level 0.3877372597529726 0.355265875826985 0.7223904173297457 1.0 0.9391262733657249 11 Q13423,P51809 2 +Intellectual disability progressive 0.3876172707439913 0.3548217651502505 0.7227231217224823 1.0 0.9391262733657249 11 O95831 1 +Thromboembolism 0.4918367346938723 0.3544153965083221 0.7230275977038403 1.0 0.9391262733657249 3 P10644,Q14315 2 +Hyperhomocystinemia 0.491428571428566 0.353263393535641 0.7238909862887584 1.0 0.9391262733657249 3 Q99707,P41440 2 +Redundant skin 0.3551167537857326 0.3529547879078518 0.7241223358468418 1.0 0.9391262733657249 21 Q15056,Q8NCH0 2 +Choroid plexus carcinoma 0.4398204814361498 0.3516513411584162 0.7250997566230952 1.0 0.9391262733657249 2 P04637 1 +Thin ribs 0.386026843896678 0.348951467574576 0.7271257452557292 1.0 0.9398238373074488 11 O14802,O95831,O75844 3 +Waddling gait 0.3625810169595915 0.3464193294889684 0.7290276005554965 1.0 0.9411363094861068 18 Q7Z392,Q4J6C6,P50402,Q13510 4 +Lack of skin elasticity 0.3721371531259436 0.3449531580939199 0.7301295860953887 1.0 0.941239149504687 15 O00170,Q15334,Q9H4L7 3 +Adult onset 0.3289972818865192 0.3444302338895564 0.7305227548746713 1.0 0.941239149504687 57 Q06787,Q07021,Q8IV08,Q14203,P42345,O15118,Q9UJV9,P04062,P31751,O14979 10 +Abnormality of ocular smooth pursuit 0.3650706309785403 0.3440800389763898 0.7307860940226834 1.0 0.941239149504687 17 P35251,O14773,Q06787 3 +Proximal upper limb amyotrophy 0.4743365399046637 0.3424424954882759 0.7320179126618416 1.0 0.941239149504687 6 O14979 1 +Abnormality of the musculature of the upper arm 0.4743365399046637 0.3424424954882759 0.7320179126618416 1.0 0.941239149504687 6 O14979 1 +Prominent forehead 0.3268726521023033 0.3399864933939506 0.7338666994295142 1.0 0.9417425112300404 59 P55011,Q14738,Q96AX1,Q00577,Q9UHX1,P11233,Q15392,Q7Z6Z7,Q14739,P15586 10 +Cerebellar malformation 0.3329680430206006 0.3397889336352777 0.7340154822900438 1.0 0.9417425112300404 43 Q15056,Q9UBM7,O43505 3 +Abnormal peripheral nervous system physiology 0.3325604002995866 0.3387784795231661 0.7347766144566377 1.0 0.941752278584215 41 Q9ULM3,Q99519,O95831,O15269 4 +Abnormality of the chin 0.328290210873837 0.3387574283275393 0.7347924742017016 1.0 0.941752278584215 57 P55011,Q13045,Q9UHX1,Q06787,O75844,O14802,P27635,P11233,Q15056,P67870,Q96J02,Q96EK5,P42345,O60701,Q7LBC6,O60828,O00170,P16278 18 +High pitched voice 0.385631640776095 0.3366999302807656 0.7363431159321967 1.0 0.9428561632963552 10 P54132,O75844,Q06787 3 +Semilobar holoprosencephaly 0.4810126582278388 0.3347940231468382 0.7377804694357204 1.0 0.9428561632963552 4 O94979,A5YKK6,Q8N3U4 3 +Dilated fourth ventricle 0.3453732314767119 0.3344511962777686 0.7380391122624019 1.0 0.9428561632963552 31 Q9UBM7,O43505 2 +Personality changes 0.3695318138459429 0.3340991721588763 0.7383047247375565 1.0 0.9428561632963552 15 Q13501 1 +Toxemia of pregnancy 0.4719714980367366 0.3317389529657582 0.7400863845042305 1.0 0.9442716579071144 5 O43772 1 +Absence of secondary sex characteristics 0.4795552546887383 0.3307892208612863 0.7408037034789734 1.0 0.9442716579071144 4 P51809 1 +Aplasia hypoplasia of the abdominal wall musculature 0.4328845369237056 0.3300863454622532 0.7413347203001694 1.0 0.9442716579071144 2 Q6NUK1 1 +Iris hypopigmentation 0.4701797385620934 0.3267927791728044 0.7438246212421156 1.0 0.9454454173416238 5 Q86YV9,O95714,Q96T58,O14617 4 +Variable expressivity 0.3249866474797727 0.3246294320970823 0.7454615490633438 1.0 0.9466516583241426 59 P17900,Q9Y263,Q13510 3 +Solitary median maxillary central incisor 0.4808163265306083 0.3239417446382237 0.7459821389250465 1.0 0.9467497528792376 3 A5YKK6,Q8N3U4 2 +Abnormal gallbladder morphology 0.3454471872786909 0.3236708329611365 0.7461872550416495 1.0 0.9467497528792376 23 P04062 1 +Cerebellar cyst 0.3439701444667004 0.3230724114539907 0.7466404033203939 1.0 0.9467862683159696 30 Q9UBM7,O43505 2 +Tall stature 0.3301694762506765 0.3219510525832345 0.7474897761232207 1.0 0.9474180507148676 41 P55011,Q9NWM8,Q13423,Q8NCH0,O00170,Q15334 6 +Mitral stenosis 0.4759581390233884 0.321000986870802 0.7482096430357297 1.0 0.9474180507148676 4 P04062 1 +Neonatal death 0.3729566704306417 0.3200078738919792 0.7489623616700403 1.0 0.9475573586002828 13 P04062,Q14739 2 +Flank pain 0.428804569563442 0.3177277953605237 0.7506914252708814 1.0 0.94826988667316 2 P07741 1 +Functional abnormality of the inner ear 0.3332427646474502 0.3172257441529562 0.7510723169431102 1.0 0.94826988667316 205 O00584,P06280,P42892,Q9Y263,Q99519,Q15904,O00170,Q13510,Q13501,P55011,Q9UBM7,Q14126,P01889,P04062,O15269,Q9UG56,Q9P032,Q9BZH6,Q07021,O95721,Q15056,Q9NWM8,O43464,O95831,O15460 25 +Dysesthesia 0.4745496184067465 0.3172059637245254 0.7510873250225303 1.0 0.94826988667316 4 Q8NCH0 1 +Abnormal oral physiology 0.3295564103527755 0.3170038049636571 0.7512407151034937 1.0 0.94826988667316 48 P35637,Q13501,P55011,P01889,Q92804,O15460,Q15165,Q14739,P15586 9 +Emg myopathic abnormalities 0.3477259740607081 0.3159076754526937 0.7520725858799633 1.0 0.9485175175461642 21 Q13501,P51114 2 +Inflammatory abnormality of the eye 0.3392840399238462 0.3136643374018101 0.7537759893680249 1.0 0.9500165407007352 34 Q96AX1,P54132,P02786,Q14739 4 +Ambiguous genitalia 0.3594439736104428 0.3090111868310956 0.7573130171463927 1.0 0.9514206318900256 16 Q15392,Q9UBM7 2 +Eeg with focal epileptiform discharges 0.3405757460452518 0.3068949163650561 0.7589233586374742 1.0 0.9520506118758852 25 Q96C86,O75503 2 +Fibroadenoma of the breast 0.4247246022031846 0.3056176442235337 0.7598957847293311 1.0 0.952416318583102 2 P10644 1 +Ocular albinism 0.4699877501020701 0.3050629236545959 0.7603182286892682 1.0 0.952416318583102 4 Q96T58,O14617,Q86YV9 3 +Rickets 0.4595451854951654 0.2981278613688439 0.7656055776063984 1.0 0.9568447216030236 5 Q9UDY2 1 +Accelerated skeletal maturation 0.4012676039520092 0.2927102053822666 0.7697436686279671 1.0 0.9592274699000728 8 O00170,Q03164 2 +Action tremor 0.3263082595441915 0.2925388565488137 0.7698746552935392 1.0 0.9592274699000728 43 Q14108 1 +Abnormal social behavior 0.325397526061255 0.2918774459117597 0.7703803285446522 1.0 0.9592274699000728 51 P05067,Q9P032,Q9UHX1,Q06787,Q15056,Q10471,O96008,O43464 8 +Wormian bones 0.3654491419081225 0.2916577502290899 0.7705483157483515 1.0 0.9592274699000728 13 O95831,Q9Y487 2 +Coronal craniosynostosis 0.4681632653061185 0.2906312606479771 0.7713333490443306 1.0 0.9594230338132952 3 Q6NUK1,P16435 2 +Abnormality of the humeroradial joint 0.4268765984656051 0.2888129863585885 0.7727244937331375 1.0 0.9596381426098846 7 P48651,Q6ZRS2,Q6KC79 3 +Vascular neoplasm 0.3381110263276315 0.2886387260654369 0.772857857096092 1.0 0.9596381426098846 27 P10619,Q9UBM7 2 +Skin ulcer 0.3368577355292354 0.286882549129628 0.7742022528897317 1.0 0.9596381426098846 25 P01889,P04062,Q03519,O15269,Q14739 5 +Upper eyelid coloboma 0.4181966544267638 0.286770381329782 0.7742881431037287 1.0 0.9596381426098846 2 Q6NUK1 1 +Lacrimal duct stenosis 0.4181966544267613 0.2867703813297756 0.7742881431037336 1.0 0.9596381426098846 2 P48651 1 +Fever 0.3108396805423236 0.2861288342311288 0.774779447822427 1.0 0.9596381426098846 68 P06280,P10253,Q13510,P38571 4 +Abnormality of circulating leptin level 0.4619193530948776 0.2841527591402464 0.7762933165733408 1.0 0.9596381426098846 4 P31751 1 +Congenital bilateral hip dislocation 0.4169726642186868 0.2833103050583979 0.7769389784703276 1.0 0.9596381426098846 2 Q9Y4R8 1 +Distal joint laxity 0.4169726642186822 0.2833103050583855 0.7769389784703371 1.0 0.9596381426098846 2 O75340 1 +Calcinosis 0.452640002443934 0.2801704650817598 0.7793467250542281 1.0 0.9608949933536398 5 Q14739 1 +Finger syndactyly 0.3388738788022297 0.2799816608076458 0.7794915749836897 1.0 0.9608949933536398 22 Q9BW83,Q9UBM7,Q96EK5,Q9Y2U8,P38398 5 +Pointed chin 0.3339591035453572 0.2756174251063654 0.7828419245845186 1.0 0.9628722860962564 24 P11233,Q15056,Q96EK5 3 +Fibrous tissue neoplasm 0.3550340850400071 0.27548346804373 0.7829448252327937 1.0 0.9628722860962564 15 Q15392 1 +Renal insufficiency 0.3162052766463007 0.2746152206950081 0.7836118713504461 1.0 0.9630217579836128 62 Q9BW83,Q6ZRS2,P06280,P16930,Q15056,Q9NQW6,P01889,Q9Y5K6,Q9Y2U8,Q8NFH4,O15460,Q92947,Q14108,P35579,P38398 15 +Severe cytomegalovirus infection 0.4137086903304764 0.2741991453663356 0.7839315848599677 1.0 0.9631470555098992 2 P29144 1 +Abnormality of prenatal development or birth 0.3246334386169494 0.2726934283794928 0.7850888867187704 1.0 0.9634983756817764 179 Q9UHX1,P61916,Q8NC96,P16278,Q99519,P10619,Q9Y487,Q9H4L7,O15118,Q13510,Q13501,O43772,Q9UBM7,Q9H0R6,P04062,P08236,Q5SRE5,Q14739,P38398,Q07021,Q15056 21 +Increased connective tissue 0.4208791265635399 0.2723003112490985 0.7853911169187342 1.0 0.9635308102337043 7 O95831,P31751 2 +Aplasia hypoplasia of the optic nerve 0.3495283979381167 0.2680504440880492 0.7886604901972887 1.0 0.9649364725152444 16 Q9BZH6,Q9UHX1 2 +Premature rupture of membranes 0.4464800883020168 0.2646031216899983 0.7913152150690512 1.0 0.967649211017532 5 Q9Y487 1 +Widely patent fontanelles and sutures 0.453130109292018 0.2622250022865134 0.7931479785978168 1.0 0.9686165189835848 4 O14802,O75844 2 +Abnormal thorax morphology 0.320394254592945 0.2613574276525603 0.7938168841279012 1.0 0.9686165189835848 168 Q9UHX1,Q9Y263,P16278,P15586,Q99519,Q9Y487,P54802,Q13510,Q13501,P55011,Q96AX1,Q9UBM7,P04062,Q03164,P08236,Q14739,Q15056,O95831,Q8NCH0 19 +Atrophy degeneration affecting the brainstem 0.4168019383669231 0.2613167594094931 0.7938482433261254 1.0 0.9686165189835848 7 O00429,Q13217 2 +Abnormality of skin physiology 0.3109440275382454 0.2605207081583245 0.7944621438486512 1.0 0.9686165189835848 79 Q9UBM7,P10321,P02786,Q9H4L7,P01889,P54132,Q92542,P38571,O00170,Q8NCH0,Q14739 11 +Generalized tonic seizure 0.3591176937129844 0.2604376514695405 0.7945262030269848 1.0 0.9686165189835848 12 P67870 1 +Recurrent urinary tract infections 0.3324500671361907 0.2601679885368825 0.7947341956571172 1.0 0.9686165189835848 26 Q13423,P54132,Q15056 3 +Pericarditis 0.4428505492780674 0.2556349867436945 0.7982327002814644 1.0 0.9715418913992616 5 P01889 1 +Aggressive behavior 0.3128246968049633 0.2547426892460262 0.7989218424150155 1.0 0.9719257490796076 63 Q13501,P54802,O75503 3 +Abnormal lateral ventricle morphology 0.3307643778050106 0.2546575956786649 0.7989875703489608 1.0 0.9719257490796076 25 Q14738,Q05639,Q9UID3,P67870,Q01105,Q92947 6 +Phocomelia 0.452653061224484 0.2523910509334231 0.8007388166194025 1.0 0.9724463677805064 3 Q9Y5S9,Q6KC79 2 +Thin skin 0.3314918298016892 0.2521118867469705 0.8009545823704238 1.0 0.9724463677805064 23 Q13126,O00170,Q9H4L7,Q06787 4 +Deep palmar crease 0.3580858574525737 0.2511990052830753 0.8016602535825412 1.0 0.9730360322710152 11 Q96AX1,O00170,Q9Y487 3 +Cheilitis 0.4517541390094489 0.250265628945023 0.8023819349692398 1.0 0.9736448006499172 3 P54132 1 +Fair hair 0.4510204081632599 0.2485383128014585 0.8037179304614743 1.0 0.9746452017332344 3 P10644,O00203 2 +Abnormality of peripheral nerves 0.3259112606328409 0.2462529294127748 0.8054864449844024 1.0 0.9760460825872628 36 Q99519,O15269 2 +Congenital malformation of the great arteries 0.3091195102913901 0.2439512531550084 0.8072685737536336 1.0 0.9769385485196332 83 Q96AX1,Q9UBM7,Q9UHX1,P51571,O75844,Q15056,P01889,Q9NWM8,Q15392,P42892,O15460,P38398 12 +Furrowed tongue 0.4454879542670467 0.2439041101286473 0.8073050858781956 1.0 0.9769385485196332 4 P61978,Q15042,P21912 3 +Scrotal hypoplasia 0.3408196705055372 0.2403743140750321 0.8100400889355255 1.0 0.9779041345150864 17 O15160,Q8IWS0,Q9UBM7,Q15555 4 +Genetic anticipation 0.4006527947776375 0.239475795976576 0.8107366625284036 1.0 0.9784142587621087 2 Q9UBB4 1 +Coxa vara 0.3562282049339453 0.2391126922125306 0.8110182002439776 1.0 0.9784870430112146 10 O95831 1 +Fetal onset 0.4461224489795861 0.2371822302075204 0.8125154212832273 1.0 0.979542203543036 3 Q9Y285,P27635 2 +Deviation of the hallux 0.3283307379520068 0.23574365471408 0.8136315928520743 1.0 0.979542203543036 27 P55011,Q15056,P04062 3 +Raynaud phenomenon 0.4314223818712946 0.231598235840656 0.816850077857687 1.0 0.981830236302126 6 Q14739 1 +Hyperlordosis 0.3200915512956472 0.2290036152539549 0.818866106222869 1.0 0.981830236302126 38 Q96AX1,Q7Z392,Q15056,P50402,P16278 5 +Aplasia hypoplasia involving forearm bones 0.3456586684743714 0.2289225267253967 0.8189291316409208 1.0 0.981830236302126 14 Q9UBM7 1 +Neoplasm of the male external genitalia 0.3785704966577418 0.2278624782496635 0.8197531534140532 1.0 0.9820213307885984 8 Q13423,P51809 2 +Syringomyelia 0.4413137268861277 0.2263313547224804 0.8209437134887176 1.0 0.9826885100840592 3 Q9Y2U8 1 +Prominent superficial blood vessels 0.3518573133229098 0.2256700021034914 0.8214580910944647 1.0 0.9828436104208284 10 O14802,Q9Y487,O75844 3 +Wide anterior fontanel 0.3388039429988561 0.2255933555038121 0.8215177091851238 1.0 0.9828436104208284 16 Q14738,Q9Y487,P42345 3 +Abnormal joint morphology 0.3264798664077815 0.2251305324357031 0.8218777291452566 1.0 0.9829626896034908 206 Q9UHX1,P06280,P42892,Q14108,P16278,Q9Y487,Q9H4L7,O00170,Q13510,P55011,Q96AX1,Q9UBM7,P10321,P01889,Q15392,P04062,Q03164,Q7Z2Z2,P08236,O15269,Q14739,Q15056,O95831,Q8NCH0 24 +Entropion 0.3528905138449967 0.2248940215469524 0.8220617202901452 1.0 0.9829626896034908 9 P01889,O75844 2 +Glomerular sclerosis 0.3265619775007989 0.2245505018169323 0.8223289752593155 1.0 0.9830165020464736 28 Q96AX1,P16930,Q9NQW6,Q8NFH4,Q14108 5 +Abnormal platelet morphology 0.4293300653594791 0.2236036507783706 0.8230657226842055 1.0 0.98310010570679 5 Q86YV9,P12814,O00203,P04637 4 +Abnormal megakaryocyte morphology 0.4293300653594789 0.2236036507783697 0.8230657226842062 1.0 0.98310010570679 5 O75533,P62263,P04637,P22314 4 +Papilledema 0.3359139991966243 0.2206140526624317 0.8253929582047665 1.0 0.9840196911427715 17 P55011,P04062 2 +Carious teeth 0.3185204174389007 0.2190185202461544 0.8266356209224981 1.0 0.9850155350091534 38 Q15056,Q9Y487,P16278 3 +Increased nuchal translucency 0.3400207343188559 0.2183036252778861 0.8271925500148725 1.0 0.9853683406183088 15 Q9UBM7 1 +Abnormal labia minora morphology 0.3998364677023842 0.2178119240815509 0.8275756535382512 1.0 0.9855592664511807 7 O95714,Q9NP72,P16435,Q9Y619,Q9H2M9,Q15042 6 +Muscle weakness 0.3273558870230767 0.2173058719369514 0.827969981288406 1.0 0.9857634528233162 222 Q13126,Q9UHX1,P10253,P17900,Q8NC96,O43505,Q9Y263,P06865,Q99519,P07686,Q9BUF5,O14979,Q13510,Q13501,O43772,P01889,O15269,Q14739,Q9P032,Q9BZH6,O95721,Q92804,Q9NWM8,O95831,Q15165,Q8NCH0,O15460 27 +Low set posteriorly rotated ears 0.3145376735903538 0.2165674081542129 0.8285454874484519 1.0 0.985786180790332 53 Q9UBM7,Q15056,Q15392,P04062,Q8NCH0,Q9Y263 6 +Pediatric onset 0.3231523390458715 0.2159610502413098 0.8290181085205774 1.0 0.985786180790332 191 P06865,O00584,Q15904,P06280,P07686,O14773,O15118,P54802,P38571,P16278 10 +Contractures of the joints of the upper limbs 0.3147758340154105 0.2124791364750512 0.8317332528626611 1.0 0.987095072969166 50 P35637,O75844,P27635,Q9H4L7,Q9Y3E5,Q15392,P42892,P50402,O14802,O60568 10 +Impaired pain sensation 0.333816640740136 0.2123033425602321 0.8318703878839364 1.0 0.987095072969166 17 O15269 1 +Micropenis 0.3147296408101341 0.212150404442407 0.8319896974969594 1.0 0.987095072969166 50 P42892,O43505 2 +Dilated cardiomyopathy 0.3240332926190518 0.2100136917551423 0.8336569868580106 1.0 0.988702313792277 30 P16278 1 +Myotonia 0.3963462437054659 0.209317720034839 0.8342002195734668 1.0 0.988702313792277 7 Q00577 1 +Abnormality of temperature regulation 0.3053339352755499 0.2092971487258654 0.834216277477364 1.0 0.988702313792277 84 O43772,P06280,P10253,P38571,Q13510 5 +Abnormality of hair pigmentation 0.3241261735863401 0.2089361922507728 0.8344980502948987 1.0 0.988702313792277 22 Q9UBM7 1 +Absent forearm bone 0.4330612244897908 0.2084096225581196 0.8349091435709135 1.0 0.988702313792277 3 Q9Y5S9,Q15427 2 +Bronchomalacia 0.4330612244897902 0.2084096225581185 0.8349091435709144 1.0 0.988702313792277 3 P63000,P16435 2 +Severe infection 0.4207297088293837 0.2071764423371093 0.8358720644732391 1.0 0.9893128555432532 6 P54132,P51608,P17812 3 +Abnormality of the cervical spine 0.3046021520595134 0.2037089627158319 0.8385809378264817 1.0 0.9911928081257424 78 Q9UBM7,Q96EK5,P08236,O95831,Q8NCH0,P16278,P15586 7 +Aplasia hypoplasia of the femur 0.3427050989990882 0.2022615103044358 0.839712288396834 1.0 0.9922648815333146 11 O95831 1 +Increased megakaryocyte count 0.4289795918367287 0.1998770111245426 0.8415767701069399 1.0 0.9937933442020028 3 O75533,P04637 2 +Abnormality of long bone morphology 0.2975420064283516 0.1996164743487054 0.8417805424263607 1.0 0.9937933442020028 128 Q13501,Q13126,Q99519,P55011,Q96AX1,Q9UBM7,Q9UHX1,P38398,Q9UG56,Q15056,Q9Y487,O00170,Q7Z2Z2,P08236,O95831,P16278,Q14739 17 +Bronchitis 0.4183076617437899 0.1991494403808926 0.8421458478745669 1.0 0.9937933442020028 5 P54132 1 +Amblyopia 0.338939997929041 0.1984321531649166 0.8427069629875039 1.0 0.9939447726116613 13 Q07021 1 +Hemorrhage of the eye 0.3427800626347544 0.1963580802546943 0.8443299046159036 1.0 0.995328136491509 9 Q9Y487 1 +Cardiovascular calcification 0.3902069665905704 0.1947673255856656 0.8455751027969369 1.0 0.9962489577308248 7 P04062 1 +Lagopthalmos 0.4262672927423492 0.1943295006603758 0.845917887723304 1.0 0.9962489577308248 3 O75844 1 +Widely spaced teeth 0.319603876486471 0.1942092988184611 0.8460120020883966 1.0 0.9962489577308248 23 P08236,P16278 2 +Antineutrophil antibody positivity 0.4248979591836689 0.1915661202604042 0.8480820830637426 1.0 0.9970938472596846 3 Q96J02,P61011 2 +Non hodgkin lymphoma 0.4142156862745118 0.1904613210589845 0.8489476496944566 1.0 0.99731618980042 5 P04637,P49327,Q07864,P52701 4 +Central nervous system cyst 0.311160593642789 0.1877174349878679 0.8510981620919402 1.0 0.9982936514063464 44 Q9UBM7,Q9UHX1,O43505 3 +Long fingers 0.3052248131393466 0.1864416623937932 0.8520984232804172 1.0 0.9986304520851312 62 Q9UHX1,Q9H4L7,Q96EK5,P42892,Q03164,Q8NCH0,Q15334,O00170,Q9Y263 9 +Hypoplastic labia minora 0.411764705882355 0.1853600938609709 0.8529466064749465 1.0 0.9989803778558738 5 Q9Y619,O95714,Q9H2M9,Q15042 4 +Clitoral hypoplasia 0.411764705882355 0.1853600938609709 0.8529466064749465 1.0 0.9989803778558738 5 Q9Y619,O95714,Q9H2M9,Q15042 4 +Frequent falls 0.3193484208333147 0.1851969203952847 0.8530745844814911 1.0 0.9989803778558738 29 Q13510 1 +Pulmonary hypoplasia 0.3224201864347197 0.1828012386017416 0.8549539767248164 1.0 1.0 19 Q9UBM7 1 +Abnormal metabolism 0.3140604548201273 0.1819735877227084 0.855603453746693 1.0 1.0 37 P51571,Q15904,Q9Y487,Q10471,Q7Z2Z2 5 +Abnormal t cell morphology 0.3371777902765018 0.1812533216517902 0.8561687430207909 1.0 1.0 9 P54132,Q13546 2 +Progressive 0.301620882520703 0.1806196130934947 0.8566661600613632 1.0 1.0 88 Q13501,Q13126,P04062,P54802,O95831,P15586,Q13510 7 +Aplasia hypoplasia involving the musculature of the upper limbs 0.3745410036719686 0.1786490051545724 0.8582133128664942 1.0 1.0 2 Q9Y5S9 1 +Cortical dysplasia 0.316421663295774 0.177630283280997 0.859013340120407 1.0 1.0 26 P55011,Q96C86,O43505 3 +Poor appetite 0.3357190107836197 0.1774050895181621 0.8591902098694528 1.0 1.0 9 P54132 1 +Abnormal cerebral ventricle morphology 0.3157668889400861 0.1754939262024391 0.8606915429112267 1.0 1.0 175 O00584,Q9UHX1,O43505,Q9Y263,P16278,Q99519,Q5MNZ6,Q9Y487,Q96AX1,Q9UBM7,Q15392,P04062,P08236,Q5SRE5,Q7Z6Z7,P38398,P67870,Q96EK5,Q01105,O60701,O43464,Q8NCH0 22 +Aplasia hypoplasia of the cerebral white matter 0.4068627450980409 0.1753904388434736 0.8607728528402143 1.0 1.0 5 Q9Y617,Q9Y320,P00403,O60341 4 +Abnormal uvea morphology 0.3011735584846289 0.1747760264664649 0.8612556264801543 1.0 1.0 77 Q96AX1,Q9UBM7,Q9UHX1,Q15056,Q96EK5,P01889,P54132,O43505 8 +Clubbing 0.3271764687787364 0.1725814653306701 0.8629804217990862 1.0 1.0 15 Q96AX1,Q9H4L7,P38398 3 +Decreased cd4 cd8 ratio 0.4138775510204035 0.1702452421122456 0.8648172729487937 1.0 1.0 3 O00203,P17812 2 +Limb girdle muscle atrophy 0.3312493955629351 0.170111786344161 0.8649222244532362 1.0 1.0 12 Q7Z392,O14979,P50402 3 +Osteopenia 0.3021273238746432 0.1687690366064639 0.8659783141294373 1.0 1.0 63 Q13126,Q14108,Q15056,Q9Y487,Q9NWM8,P04062,Q7Z2Z2,O00170 8 +Hoarse voice 0.3119297403655171 0.1654354678114014 0.8686012389956612 1.0 1.0 24 Q8N0X7,Q15056,Q9Y2U8,O00170,Q13510 5 +Abnormal synaptic transmission at the neuromuscular junction 0.3114941759625211 0.1633698644212806 0.8702272287962485 1.0 1.0 24 P35637,Q13501,Q15165,Q92804 4 +Cerebral white matter hypoplasia 0.4066966108615764 0.1622352384831493 0.8711206110682466 1.0 1.0 4 Q9Y617,Q9Y320,O60341 3 +Systemic lupus erythematosus 0.3999183006535968 0.1618029111251477 0.8714610605071764 1.0 1.0 5 P29144,Q9UJV9,P49327,P00491 4 +Enlarged kidney 0.3994855829110308 0.160977198772275 0.8721113591556531 1.0 1.0 5 Q96AX1 1 +Poor coordination 0.3980001917821105 0.159906760469949 0.8729545229667619 1.0 1.0 6 Q7Z6Z7 1 +Gait disturbance 0.3224569713061457 0.1592677860111268 0.8734578998019442 1.0 1.0 251 P35637,P05067,Q14738,O75503,Q8IV08,Q8NC96,Q14108,P16278,Q00577,Q99519,Q5MNZ6,Q06787,Q7Z392,Q9UID3,O14773,O15118,Q13217,Q13510,Q13501,P55011,Q96AX1,P01889,P04062,Q03164,Q7Z6Z7,O15269,Q9BZH6,Q15056,O43464,Q96C86,O95831 31 +Abnormal stomach morphology 0.3032050138506985 0.1592224316356823 0.87349363141435 1.0 1.0 60 Q9UBM7,Q15056,P04062,Q8NCH0,Q14739 5 +Broad nasal tip 0.3068412876510452 0.156444891407249 0.8756823545433505 1.0 1.0 39 Q9UHX1,Q9Y487,Q7Z6Z7,O95831,P16278 5 +Abnormal aggressive impulsive or violent behavior 0.2994694617275016 0.1558088403014354 0.8761837021804852 1.0 1.0 80 Q13501,Q9UBM7,O75503,P67870,P54802 5 +Hypoglycemic seizures 0.3718779899669473 0.1543825444718712 0.8773081161481735 1.0 1.0 7 Q13423 1 +Optic nerve hypoplasia 0.3253474709005216 0.1527101248524151 0.8786268759447089 1.0 1.0 12 Q9UHX1 1 +Symphalangism affecting the phalanges of the hand 0.4040918799298598 0.1526935191816556 0.878639971776205 1.0 1.0 3 O60828 1 +Proximal symphalangism 0.4040918799298598 0.1526935191816556 0.878639971776205 1.0 1.0 3 O60828 1 +Distal upper limb amyotrophy 0.3251243048133143 0.15206472482706 0.8791358861090981 1.0 1.0 12 Q13501,O60568,Q14203,Q15120 4 +Carpal bone hypoplasia 0.4009799918334042 0.1518623999622348 0.8792954647473974 1.0 1.0 4 Q9NR45,Q9Y5S9,Q14807 3 +Aplasia hypoplasia involving the carpal bones 0.4009799918334042 0.1518623999622348 0.8792954647473974 1.0 1.0 4 Q9NR45,Q9Y5S9,Q14807 3 +Arnold chiari malformation 0.3222667362460784 0.1499433352212237 0.8808093216175219 1.0 1.0 14 Q9Y2U8,Q15056 2 +Symptomatic seizures 0.3460872316592199 0.1477383066303243 0.8825492990259425 1.0 1.0 8 Q13423 1 +Lower limb pain 0.400816326530606 0.147109783382445 0.8830453678739416 1.0 1.0 3 O95140,Q8WVX9 2 +Large hands 0.343360507358565 0.1417448461017851 0.8872815504761131 1.0 1.0 8 O14802,O00170 2 +Accessory oral frenulum 0.3553651570787386 0.1415455563681749 0.8874389735120112 1.0 1.0 2 P17612 1 +Prolonged partial thromboplastin time 0.3882672831036384 0.1404346606553351 0.888316573950855 1.0 1.0 5 P28288,Q7Z2Z2 2 +Pleural effusion 0.3207658784776127 0.1400399236237131 0.8886284466822527 1.0 1.0 9 P01889,Q14739 2 +Neoplasm of the larynx 0.3963265306122407 0.1396936362429363 0.8889020546466568 1.0 1.0 3 P04637,P52701 2 +Proximal amyotrophy 0.3187018128298648 0.1338918464913802 0.8934880977891693 1.0 1.0 12 P35637,O14979 2 +Interictal eeg abnormality 0.3004044219825492 0.1335735657163782 0.893739788339573 1.0 1.0 59 O75503,Q8NC96,Q96C86,Q14108,Q9Y263 5 +Abnormality of hepatobiliary system physiology 0.2982057637255813 0.1322142180419138 0.8948148554758952 1.0 1.0 62 P38571,O43772,Q13510,O15118 4 +Secondary microcephaly 0.3018245460694803 0.1301988298451331 0.8964091203490165 1.0 1.0 55 Q9UHX1,Q9Y487,P50897,O43464,Q9Y263 5 +Gynecomastia 0.3105349657944832 0.129780185375037 0.896740340096176 1.0 1.0 18 Q9BZH6,Q06787,P51809,Q8IWS0,P31751,O00170 6 +Global brain atrophy 0.3107326716971821 0.1267367962336761 0.8991487214660832 1.0 1.0 17 Q13501,Q9UHX1 2 +Abnormal corneal epithelium morphology 0.3112152852629956 0.1264553868150982 0.8993714616446082 1.0 1.0 16 P01889,Q96EK5,Q14739 3 +Abnormality of the hypothenar eminence 0.3855360840998055 0.1260218904390132 0.8997145966526692 1.0 1.0 4 Q7Z392 1 +Abnormal upper limb bone morphology 0.2927735658556467 0.1245108466150153 0.9009108128525803 1.0 1.0 70 P55011,P38398,Q9UBM7,Q9UHX1,Q15056,P08236,P16278,Q14739 8 +Porokeratosis 0.3451652386780868 0.1244287178456124 0.9009758364770896 1.0 1.0 2 P14324 1 +Patellar hypoplasia 0.3451652386780867 0.1244287178456121 0.9009758364770896 1.0 1.0 2 Q8N806 1 +Increased circulating prolactin concentration 0.3776230225284249 0.1224903768135639 0.9025106667943016 1.0 1.0 5 O00170 1 +Severe intrauterine growth retardation 0.3851854227411262 0.1224733194048736 0.9025241749331634 1.0 1.0 3 O14802 1 +Abnormality of the knee 0.2943123614771403 0.1215345217575362 0.903267672944231 1.0 1.0 65 P08236,Q15056,P16278,Q13510 4 +Oromotor apraxia 0.379746835443042 0.1171558761180198 0.9067365318125198 1.0 1.0 4 Q14683,P39656,Q8N3U4 3 +Limited extraocular movements 0.3797468354430419 0.1171558761180198 0.9067365318125198 1.0 1.0 4 O75306,P51659,Q9UHD1 3 +Caesarian section 0.3793385055124571 0.1165473545270714 0.9072187582910584 1.0 1.0 4 O14802,O60313,P33991 3 +Abnormal ovarian morphology 0.30305994918868 0.1158147361935975 0.9077993713148178 1.0 1.0 22 Q9BZH6,P31751,P51809,Q15056 4 +Thoracic aortic aneurysm 0.3048840623918018 0.114576226399054 0.908781024174153 1.0 1.0 28 P55011,Q06787,Q15056,P01889,Q7Z6Z7 5 +Dyspnea 0.2949402441229039 0.1144763030575997 0.9088602303141352 1.0 1.0 82 Q13501,Q96AX1,P35637,Q00577,P51571,Q9UHX1,O75844,P06280,P01889,Q92804,P10253,P04062,O95831,Q15165,Q13510 15 +Tonic seizure 0.3058175015165476 0.1129010279315737 0.9101090213714598 1.0 1.0 18 Q05639,Q00577,P27635,P67870,Q01105 5 +Bowing of the arm 0.3748468762760346 0.109999331401914 0.9124099051617618 1.0 1.0 4 Q32P28,P16435,O75369 3 +Tibial bowing 0.3746938775510156 0.107783347468211 0.9141675527228998 1.0 1.0 3 Q32P28,O75369 2 +Radial bowing 0.3746938775510156 0.107783347468211 0.9141675527228998 1.0 1.0 3 Q32P28,O75369 2 +Fibular aplasia 0.3746938775510151 0.1077833474682102 0.9141675527229004 1.0 1.0 3 Q9Y5S9,O75369 2 +Broad distal phalanx of finger 0.3746938775510145 0.1077833474682093 0.9141675527229012 1.0 1.0 3 Q14807,O75369 2 +Gastrointestinal inflammation 0.3070859274605194 0.1076674473746893 0.9142594925972236 1.0 1.0 15 Q7Z392,P08183,P01889,O15143 4 +Fatty replacement of skeletal muscle 0.3653453208009897 0.1035547198685979 0.917522722704046 1.0 1.0 6 Q7Z406,P09651,P51114,P22626,Q8NFF5 5 +Abnormality of the axillary hair 0.3653263104850007 0.1035259514717686 0.917545553853304 1.0 1.0 6 P51809 1 +Abnormal magnesium concentration 0.3710204081632602 0.1029848231902319 0.9179750162420826 1.0 1.0 3 Q9NP81,Q15813 2 +Abnormal hypothalamus morphology 0.3304773561811486 0.1029042312990692 0.9180389794407896 1.0 1.0 2 Q9H269 1 +Retinal fold 0.3304773561811454 0.1029042312990647 0.9180389794407932 1.0 1.0 2 P52732 1 +Vitreous hemorrhage 0.330477356181145 0.1029042312990645 0.9180389794407936 1.0 1.0 2 O75533 1 +Calvarial hyperostosis 0.3650469579420192 0.0966331977204566 0.9230176918887631 1.0 1.0 4 P10644,P22626,P09651 3 +Aplasia hypoplasia of the ovary 0.3003801635786367 0.0954315856882185 0.9239720288062584 1.0 1.0 9 P51809,Q9BZH6 2 +Limitation of knee mobility 0.3648979591836684 0.0953785925125246 0.9240141192500456 1.0 1.0 3 P21333,Q14315 2 +Tracheoesophageal fistula 0.299888993685111 0.0924442463745236 0.9263450863875826 1.0 1.0 18 P55011,Q15056 2 +Abnormality of the musculature of the thigh 0.3181870143925917 0.0920286776342636 0.9266752548109902 1.0 1.0 8 O14979 1 +Glioblastoma multiforme 0.3563547200653891 0.0904717757559236 0.9279123216392792 1.0 1.0 6 O75874,P43246,P52701,P04637,P60866 5 +Dental crowding 0.2977207852215672 0.0885371005481311 0.9294497981323876 1.0 1.0 19 Q9UBM7 1 +Weakness of facial musculature 0.2944593272030988 0.0884126753433281 0.929548687281272 1.0 1.0 41 Q13501,Q9UHX1,Q13510 3 +Myalgia 0.2987605480132157 0.0878006063525533 0.9300351558282848 1.0 1.0 36 Q06787,P06280,Q7Z392,P01889,O15460,Q14739 6 +Abnormality of the skull base 0.2949197192936362 0.0859814185064665 0.9314811884009968 1.0 1.0 43 Q14739,Q9UBM7,Q9UHX1,O43505 4 +Distal sensory impairment 0.3000810683509 0.0858191857756482 0.931610154700955 1.0 1.0 31 P54802,O15269 2 +Cardiac diverticulum 0.356063699469175 0.0854728069464669 0.9318855132552422 1.0 1.0 4 P43246,P60866,P52701 3 +Macrodontia 0.2976681312615967 0.0850029902540717 0.9322590134369204 1.0 1.0 18 P55011,Q00577,P38398,Q7Z6Z7 4 +Bilateral sensorineural hearing impairment 0.2952616357010347 0.0849718225473397 0.9322837920210229 1.0 1.0 20 P35637,Q13501,P55011 3 +Hypertriglyceridemia 0.2953869341364542 0.0843311828355956 0.9327931203820654 1.0 1.0 21 Q13045,P31751,P06737,P50402,P38571 5 +Thoracic hypoplasia 0.2948114184807941 0.08431581486182 0.9328053387347544 1.0 1.0 23 P04062,Q14739 2 +Joint hypermobility 0.2895850515797656 0.0839119579336076 0.9331264320378728 1.0 1.0 74 P55011,O75179,Q15904,Q9UHX1,Q15056,Q9Y487,Q9NWM8,Q01105,Q03164,Q9Y263 10 +Lower limb asymmetry 0.3529837214032164 0.0818823645394322 0.9347402584000796 1.0 1.0 4 P07437,Q15555 2 +Testicular atrophy 0.351572070232747 0.0802764703759006 0.936017371726442 1.0 1.0 4 O76024,P00492,P04637 3 +Chordee 0.3481814466693969 0.079480857805105 0.9366501566985432 1.0 1.0 6 P16435,P49589,O60341,P48651,P53701 5 +Abnormal renal corticomedullary differentiation 0.3096695226438122 0.0784157807525084 0.9374973209584032 1.0 1.0 2 Q6KC79 1 +Reduced renal corticomedullary differentiation 0.3096695226438122 0.0784157807525084 0.9374973209584032 1.0 1.0 2 Q6KC79 1 +Aplasia hypoplasia of the patella 0.3455882352941197 0.0775289858084071 0.9382027333221634 1.0 1.0 5 Q8N806,Q9Y619,Q96AY3,Q9Y5S9 4 +Delayed menarche 0.34541527254167 0.0773223735110674 0.938367092699406 1.0 1.0 5 O75844 1 +Abnormality of the radial head 0.3457294646505976 0.0763494779225181 0.9391410629957596 1.0 1.0 6 Q6ZRS2,P21333,P10644,Q14807,Q6KC79 5 +Epispadias 0.3478971008574948 0.076211827207302 0.9392505733063066 1.0 1.0 4 Q9Y619,P53701,P48651 3 +Alacrima 0.3448352092523662 0.0752263480497162 0.9400346210329352 1.0 1.0 6 P55011,Q7Z392 2 +Lacrimation abnormality 0.2956240123312925 0.0745455867500622 0.9405762690656404 1.0 1.0 15 P55011,Q15056 2 +Patellar aplasia 0.3453061224489737 0.0742235148089804 0.9408325353436712 1.0 1.0 3 Q9Y619,Q9Y5S9 2 +Abnormal involuntary eye movements 0.3169599410971794 0.0739761261042222 0.9410293818080532 1.0 1.0 227 P35637,O00584,O75503,Q8IV08,P17900,Q8NC96,Q9Y263,Q99519,O14773,Q10471,Q13510,Q13501,P55011,Q96AX1,O43772,Q9UBM7,P01889,Q15392,P04062,P38398,Q9P032,Q9BZH6,Q15056,Q7Z6Z7,O95831,O15460 26 +Sudden death 0.2925666490962628 0.0736604896053028 0.9412805380701368 1.0 1.0 22 Q14126,P01889,Q15056 3 +Prolonged bleeding time 0.325020441537206 0.0729127983381552 0.9418755094518404 1.0 1.0 7 Q86YV9,Q15149,P04637,O00203,P27797,P35579 6 +Hemivertebrae 0.2876454387137364 0.0713782276644688 0.943096737211072 1.0 1.0 9 Q9UM00,Q9UHX1 2 +Chronic lung disease 0.2870208843096171 0.0702744673774639 0.9439752043341708 1.0 1.0 9 P54132,Q13546 2 +Adenomatous colonic polyposis 0.3406892647354996 0.0699167105222299 0.9442599526041088 1.0 1.0 3 Q07864 1 +Abnormality of the plantar skin of foot 0.2954172814067488 0.0698770128268539 0.9442915495035452 1.0 1.0 36 Q7Z392,Q14126,O95721,Q9Y487,Q9H4L7,Q9Y2U8,P20810,O00170,Q9Y263 9 +Supernumerary nipple 0.3040834332245338 0.0686527582573348 0.9452660228777944 1.0 1.0 8 Q14738 1 +Cerebral hypoplasia 0.2921095513573781 0.0650938284104288 0.9480992942279048 1.0 1.0 13 Q5MNZ6,P35606,Q9UBM7 3 +Chorea 0.2902174010981609 0.0641974364919721 0.9488130185693952 1.0 1.0 60 P35637,P55011,P67870,P17900,Q01105,O60701,Q96C86 7 +Abnormality of male internal genitalia 0.2998531823133991 0.0622655518148092 0.9503513608948604 1.0 1.0 8 Q8IWS0,P38398 2 +Increased hepatic glycogen content 0.333267337680621 0.0616498668054117 0.9508416644684066 1.0 1.0 4 P31751 1 +Abnormality of the nasal bone 0.3306122448979533 0.0613652184685494 0.9510683517758768 1.0 1.0 3 Q6NUK1,P10644 2 +Decreased specific antibody response to vaccination 0.3286057809818559 0.059796987735714 0.9523173247243713 1.0 1.0 3 Q13546 1 +Joint laxity 0.289537405032299 0.059416772613384 0.9526201540470178 1.0 1.0 60 Q9UHX1,Q15056,Q9Y487,Q8NCH0,Q96C86,Q15334,P16278 7 +Retinal telangiectasia 0.3307472437729707 0.0593946968376708 0.9526377369149046 1.0 1.0 4 O75306,Q14331,P12004 3 +Abnormality of the nasal skeleton 0.3307472437729705 0.0593946968376706 0.9526377369149048 1.0 1.0 4 Q6NUK1,P10644,P22314 3 +Microdontia 0.2884933420990612 0.0589814987209226 0.9529668443356564 1.0 1.0 23 Q9UM00,Q9Y487,Q15056,Q15555 4 +Abnormal atrioventricular valve morphology 0.2890135347087074 0.057408465382228 0.9542198197256138 1.0 1.0 25 Q15056,P04062,Q06787 3 +Otitis media 0.2890544525950291 0.0566795446750619 0.954800468800706 1.0 1.0 41 Q15056,Q9UBM7,P54132,Q14739 4 +Arm dystonia 0.3253472006438866 0.0548033843606523 0.956295104126851 1.0 1.0 4 P35637 1 +Renal agenesis 0.2881003415776088 0.0544436845023695 0.9565816752441978 1.0 1.0 40 Q15392,Q9UBM7,O75179 3 +Abnormality of the phalanges of the toes 0.3232153141357808 0.0510795415815897 0.9592621381610592 1.0 1.0 6 P38398 1 +Abnormality of the cerebrospinal fluid 0.2761571114379167 0.0507643032624713 0.959513336053234 1.0 1.0 109 P55011,Q96AX1,Q99519,Q9UBM7,Q15392,P04062,O43464,O43505,P08236,O95831,P38398 11 +Somatic mutation 0.2921110472267614 0.049830935347963 0.9602571144554336 1.0 1.0 30 P11717,O00170,Q92804,P38398 4 +Aplasia hypoplasia of the skin 0.2902511836378482 0.0481016824710673 0.9616352053415624 1.0 1.0 50 Q13126,O75844,Q06787,Q9H4L7,Q9NWM8,Q15392,Q8NCH0,O00170,Q15334 9 +Abnormality of primary teeth 0.280100945314255 0.0464979066017754 0.9629134025732756 1.0 1.0 11 Q9UM00,Q00577,Q13045,O75844 4 +Polyneuropathy 0.2839344664872292 0.0444648397098954 0.964533878089944 1.0 1.0 14 O95831 1 +Thin clavicles 0.3045066183303583 0.0441715337634499 0.964767672664434 1.0 1.0 3 O75844 1 +Wrist flexion contracture 0.3099224173131959 0.0434155204013123 0.9653703058753532 1.0 1.0 4 O94905,P21333,P51608 3 +Narrow nasal bridge 0.3024489795918309 0.043092078913641 0.965628133546965 1.0 1.0 3 O95714,Q6ZRS2 2 +Shoulder girdle muscle weakness 0.3001649073200097 0.0423993774790233 0.966180324604347 1.0 1.0 7 O14979 1 +Hypoglycemic coma 0.2695716220761528 0.0422815555082464 0.9662742487083756 1.0 1.0 9 Q13423 1 +Ankylosis 0.3088220192985951 0.0417501760617624 0.966697854092333 1.0 1.0 5 O75844 1 +Increased adipose tissue 0.307017172582185 0.0415418802430566 0.9668639060478388 1.0 1.0 4 P31751 1 +Osteosarcoma 0.2833078899307204 0.0404540743690402 0.9677311203890652 1.0 1.0 21 Q13501 1 +Bloody diarrhea 0.304091284401073 0.0397372749567837 0.9683025840158984 1.0 1.0 4 Q02241 1 +Abnormality of metacarpophalangeal joint 0.3025724785626831 0.0388324532892863 0.9690239703572888 1.0 1.0 4 O60828,P21333,P16435 3 +Synostosis involving digits 0.3025724785626816 0.0388324532892855 0.9690239703572896 1.0 1.0 4 O60828,P48651,Q9H1A4 3 +Cessation of head growth 0.3095745171071103 0.038689289285035 0.969138112929439 1.0 1.0 6 Q9Y263 1 +Abnormality of the tarsal bones 0.2829798438811555 0.037871626872798 0.969790035289546 1.0 1.0 22 Q9Y263,Q9UHX1,Q14739 3 +Delayed ability to roll over 0.2906122448979539 0.0375742858168832 0.9700271103849858 1.0 1.0 3 P82663,P51608 2 +Premature skin wrinkling 0.2804360958446725 0.0353066826392053 0.9718351946791292 1.0 1.0 15 O14802,Q9Y487,O75844 3 +Renal cyst 0.2867110084032073 0.0292896718196186 0.9766335640638986 1.0 1.0 47 Q15056,Q9UBM7,O43505 3 +Aplasia hypoplasia of the hallux 0.2790167531420897 0.0291139788087703 0.9767736870470778 1.0 1.0 17 P55011,Q9UHX1 2 +Abnormal sacrum morphology 0.2819135961064583 0.0287531002482515 0.9770615059782948 1.0 1.0 25 Q15056,P01889,Q14739 3 +Abnormal sclera morphology 0.2802671029238236 0.0282388106521035 0.9774716831325928 1.0 1.0 22 Q96EK5 1 +Abnormal blood phosphate concentration 0.2876575470697264 0.027874411328586 0.9777623173129222 1.0 1.0 5 P16930 1 +Ovarian cyst 0.2760565614912162 0.0268012735535011 0.9786182374352386 1.0 1.0 14 Q15056 1 +Myofibrillar myopathy 0.2542857142857088 0.0267482327627715 0.978660542696477 1.0 1.0 3 Q13642,Q14315 2 +Adrenal hypoplasia 0.2808673835897974 0.0243458399891176 0.9805767489298434 1.0 1.0 7 Q9BZH6,O75844 2 +Postnatal growth retardation 0.2863416147079027 0.0240521668039457 0.9808109976322748 1.0 1.0 50 O75179,Q9Y487,P17900,P54132,P08236 5 +Abnormality of the nasal tip 0.2824207797336526 0.0234347667112094 0.9813034727897412 1.0 1.0 75 Q00577,Q9UHX1,Q9Y487,Q96EK5,P42892,Q03164,Q7Z6Z7,O95831,P16278 9 +Abnormal blood monovalent inorganic cation concentration 0.2744581423372268 0.0233890523460489 0.9813399375810417 1.0 1.0 14 Q13423 1 +Oligodontia 0.2545235776050534 0.0224483580685138 0.9820903058961068 1.0 1.0 9 O14802,Q7Z6Z7 2 +Ankyloglossia 0.2713288081307669 0.019975825455828 0.984062657209102 1.0 1.0 5 O75844 1 +Hyperactivity 0.2781802829912796 0.0193233301286644 0.9845831726506662 1.0 1.0 122 O75179,Q9UBM7,Q9UHX1,O75503,Q15056,P54802,Q96C86,P15586 8 +Gastritis 0.2674981563742813 0.0184331829794615 0.9852932807459384 1.0 1.0 5 Q13546 1 +Hyperthyroidism 0.2771794579509311 0.0171039226926581 0.98635370951473 1.0 1.0 6 Q06787 1 +Cleft soft palate 0.2851565700419746 0.0168949522030508 0.9865204197519726 1.0 1.0 50 Q15392,O43505 2 +Polyphagia 0.2742133224356377 0.0156180656759416 0.987539093115278 1.0 1.0 6 Q9H2P0,O95714,P35222,Q4J6C6,Q96T58 5 +Achilles tendon contracture 0.2561942980714848 0.0154707694209357 0.987656604324994 1.0 1.0 10 P50402 1 +Pseudobulbar paralysis 0.2703184390751488 0.0137783053464923 0.9890068507174614 1.0 1.0 6 Q14203 1 +Duplication of hand bones 0.2819315099136707 0.0134533914339585 0.9892660704810604 1.0 1.0 42 Q9BW83,P08708,Q9UBM7,Q9UHX1,Q9Y2U8,Q9UM00,P54132,Q9Y263,Q14739 9 +Carcinoma 0.2467320261437933 0.0118271454079182 0.990563523279044 1.0 1.0 5 P43246,Q07864,P51532,O60832 4 +Shallow orbits 0.2533767895449405 0.010028257680357 0.9919987421343344 1.0 1.0 8 O75844 1 +Asymmetric growth 0.2600945611731864 0.0098193923598435 0.9921653843427 1.0 1.0 7 P31751,Q15555 2 +Specific learning disability 0.2835456742007665 0.0072671736051764 0.994201685416384 1.0 1.0 50 P35637,Q13501,Q06787,Q96EK5,P42345,Q9Y2U8,P54132,O43505 8 +Color vision defect 0.263533103500557 0.0062223009190677 0.9950353542000828 1.0 1.0 13 Q9BZH6,O43464 2 +Decreased circulating level of specific antibody 0.2101513891593953 0.005651346872219 0.9954909015846491 1.0 1.0 5 Q13546 1 +Narrow nose 0.2095588235294141 0.0055924803072791 0.9955378695657168 1.0 1.0 5 Q9Y4L1,Q14683,Q07864,P49589 4 +Allergy 0.2090017889778804 0.0055380663566183 0.9955812849444944 1.0 1.0 5 P42345,Q6P1M0 2 +Focal impaired awareness seizure 0.2678457653034881 0.005228986928485 0.9958278910736424 1.0 1.0 16 P67870 1 +Abnormal cardiac ventricle morphology 0.2898874235997953 0.0052197142716026 0.9958352894824404 1.0 1.0 146 O43772,Q9UBM7,Q07021,P06280,Q15056,P10253,P42892,Q14739 8 +Impaired tandem gait 0.2653376128598256 0.0050270891951034 0.9959889800396212 1.0 1.0 14 P55011,Q7Z6Z7 2 +Dermal translucency 0.2454239760716156 0.0046925857275691 0.9962558720389084 1.0 1.0 6 O75844 1 +Progressive cerebellar ataxia 0.2817005953113357 0.0044776038210194 0.996427400979622 1.0 1.0 30 Q13501,Q9Y487,O14773 3 +Toe walking 0.2668815481322922 0.0030584522442939 0.9975597119787876 1.0 1.0 16 P35637,O95831,P50402 3 +Abnormality of the neck 0.2789620697329084 0.0021513567127787 0.9982834670182096 1.0 1.0 126 P35637,Q14738,Q9UHX1,P16278,P15586,Q9UID3,Q9Y487,Q13501,Q96AX1,P08708,Q9UBM7,O75844,Q9UM00,Q03164,P08236,Q5SRE5,Q14739,Q9BW83,Q15056,Q96EK5,O15160,Q7Z6Z7,O95831 23 +Central hypothyroidism 0.2347336981967491 0.0020476154996519 0.9983662403480192 1.0 1.0 9 O00170 1 diff --git a/msigdb_hp/selections.json b/msigdb_hp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..ec842720444815d27f0429a115ed286a6f752f46 --- /dev/null +++ b/msigdb_hp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["11 pairs of ribs", "2 3 finger syndactyly", "2 3 toe cutaneous syndactyly", "2 3 toe syndactyly", "3 4 finger syndactyly", "3 methylglutaconic aciduria", "4 5 toe syndactyly", "Abdominal aortic aneurysm", "Abdominal distention", "Abdominal obesity", "Abdominal pain", "Abdominal wall muscle weakness", "Abducens palsy", "Abnormal 2nd finger morphology", "Abnormal 3rd finger morphology", "Abnormal 5th finger morphology", "Abnormal 5th finger phalanx morphology", "Abnormal abdomen morphology", "Abnormal acetabulum morphology", "Abnormal activity of mitochondrial respiratory chain", "Abnormal adipose tissue morphology", "Abnormal aggressive impulsive or violent behavior", "Abnormal aldolase level", "Abnormal anatomic location of the heart", "Abnormal anterior chamber morphology", "Abnormal anterior eye segment morphology", "Abnormal anterior horn cell morphology", "Abnormal aortic arch morphology", "Abnormal aortic morphology", "Abnormal aortic valve cusp morphology", "Abnormal aortic valve morphology", "Abnormal aortic valve physiology", "Abnormal arachnoid mater morphology", "Abnormal arm span", "Abnormal arterial physiology", "Abnormal astrocyte morphology", "Abnormal atrial arrangement", "Abnormal atrioventricular conduction", "Abnormal atrioventricular valve morphology", "Abnormal atrioventricular valve physiology", "Abnormal auditory evoked potentials", "Abnormal autonomic nervous system physiology", "Abnormal b cell morphology", "Abnormal b cell subset distribution", "Abnormal basal ganglia mri signal intensity", "Abnormal basophil count", "Abnormal basophil morphology", "Abnormal biliary tract morphology", "Abnormal bleeding", "Abnormal blistering of the skin", "Abnormal blood carbon dioxide level", "Abnormal blood chloride concentration", "Abnormal blood gas level", "Abnormal blood glucose concentration", "Abnormal blood inorganic cation concentration", "Abnormal blood ion concentration", "Abnormal blood monovalent inorganic cation concentration", "Abnormal blood phosphate concentration", "Abnormal blood potassium concentration", "Abnormal blood sodium concentration", "Abnormal blood transition element cation concentration", "Abnormal blood zinc concentration", "Abnormal bone structure", "Abnormal brain choline level by mrs", "Abnormal brain lactate level by mrs", "Abnormal brain n acetyl aspartate level by mrs", "Abnormal brain positron emission tomography", "Abnormal brainstem morphology", "Abnormal brainstem mri signal intensity", "Abnormal branching pattern of the aortic arch", "Abnormal breath sound", "Abnormal bronchoalveolar lavage fluid morphology", "Abnormal bronchus morphology", "Abnormal bronchus physiology", "Abnormal c peptide level", "Abnormal c reactive protein level", "Abnormal calcium phosphate regulating hormone level", "Abnormal cardiac atrium morphology", "Abnormal cardiac septum morphology", "Abnormal cardiac test", "Abnormal cardiac ventricle morphology", "Abnormal cardiac ventricular function", "Abnormal cardiomyocyte morphology", "Abnormal carotid artery morphology", "Abnormal cartilage morphology", "Abnormal caudate nucleus morphology", "Abnormal cd4 cd8 ratio", "Abnormal cell morphology", "Abnormal cell proliferation", "Abnormal cellular composition of bronchoalveolar fluid", "Abnormal cellular phenotype", "Abnormal central sensory function", "Abnormal cerebellar vermis morphology", "Abnormal cerebral artery morphology", "Abnormal cerebral cortex morphology", "Abnormal cerebral vascular morphology", "Abnormal cerebral vein morphology", "Abnormal cerebral ventricle morphology", "Abnormal cerebrospinal fluid metabolite concentration", "Abnormal cervical curvature", "Abnormal cervical spine morphology", "Abnormal chorioretinal morphology", "Abnormal choroid morphology", "Abnormal choroid plexus morphology", "Abnormal chromosome morphology", "Abnormal ciliary body morphology", "Abnormal circulating acetylcarnitine concentration", "Abnormal circulating albumin concentration", "Abnormal circulating amino acid concentration", "Abnormal circulating amylase level", "Abnormal circulating androgen level", "Abnormal circulating apolipoprotein concentration", "Abnormal circulating arginine concentration", "Abnormal circulating aromatic amino acid concentration", "Abnormal circulating aspartate family amino acid concentration", "Abnormal circulating bilirubin concentration", "Abnormal circulating branched chain amino acid concentration", "Abnormal circulating carbohydrate concentration", "Abnormal circulating carboxylic acid concentration", "Abnormal circulating ceruloplasmin concentration", "Abnormal circulating cholesterol concentration", "Abnormal circulating citrulline concentration", "Abnormal circulating copper concentration", "Abnormal circulating creatinine concentration", "Abnormal circulating dehydroepiandrosterone concentration", "Abnormal circulating dicarboxylic acid concentration", "Abnormal circulating estrogen level", "Abnormal circulating fatty acid anion concentration", "Abnormal circulating fatty acid concentration", "Abnormal circulating ferritin concentration", "Abnormal circulating follicle stimulating hormone concentration", "Abnormal circulating free fatty acid concentration", "Abnormal circulating gaba concentration", "Abnormal circulating glutamine concentration", "Abnormal circulating glutamine family amino acid concentration", "Abnormal circulating glycine concentration", "Abnormal circulating gonadotropin concentration", "Abnormal circulating hormone concentration", "Abnormal circulating iga level", "Abnormal circulating ige level", "Abnormal circulating igg level", "Abnormal circulating igm level", "Abnormal circulating inhibin level", "Abnormal circulating lipid concentration", "Abnormal circulating long chain fatty acid concentration", "Abnormal circulating metabolite concentration", "Abnormal circulating methionine concentration", "Abnormal circulating monocarboxylic acid cocentration", "Abnormal circulating nitrogen compound concentration", "Abnormal circulating non proteinogenic amino acid concentration", "Abnormal circulating nucleobase concentration", "Abnormal circulating phenylalanine concentration", "Abnormal circulating porphyrin concentration", "Abnormal circulating progesterone level", "Abnormal circulating proline concentration", "Abnormal circulating protein concentration", "Abnormal circulating proteinogenic amino acid concentration", "Abnormal circulating proteinogenic amino acid derivative concentration", "Abnormal circulating pyruvate family amino acid concentration", "Abnormal circulating renin", "Abnormal circulating serine concentration", "Abnormal circulating serine family amino acid concentration", "Abnormal circulating sex hormone concentration", "Abnormal circulating sulfur amino acid concentration", "Abnormal circulating tyrosine concentration", "Abnormal clavicle morphology", "Abnormal cns myelination", "Abnormal cochlea morphology", "Abnormal conjugate eye movement", "Abnormal conjunctiva morphology", "Abnormal connection of the cardiac segments", "Abnormal consumption behavior", "Abnormal conus terminalis morphology", "Abnormal cornea morphology", "Abnormal corneal endothelium morphology", "Abnormal corneal epithelium morphology", "Abnormal coronary artery morphology", "Abnormal corpus callosum morphology", "Abnormal corpus striatum morphology", "Abnormal cortical bone morphology", "Abnormal cortical gyration", "Abnormal cranial nerve morphology", "Abnormal cranial nerve physiology", "Abnormal cry", "Abnormal csf carboxylic acid concentration", "Abnormal csf metabolite level", "Abnormal csf protein level", "Abnormal csf pyruvate family amino acid concentration", "Abnormal cutaneous elastic fiber morphology", "Abnormal delayed hypersensitivity skin test", "Abnormal delivery", "Abnormal dense granules", "Abnormal dental pulp morphology", "Abnormal dental root morphology", "Abnormal dentate nucleus morphology", "Abnormal dentin morphology", "Abnormal dermatoglyphics", "Abnormal dermoepidermal junction morphology", "Abnormal descemet membrane morphology", "Abnormal diaphysis morphology", "Abnormal distal phalanx morphology of finger", "Abnormal dlco", "Abnormal drinking behavior", "Abnormal duodenum morphology", "Abnormal dura mater morphology", "Abnormal eating behavior", "Abnormal echocardiogram", "Abnormal elasticity of skin", "Abnormal electrophysiology of sinoatrial node origin", "Abnormal electroretinogram", "Abnormal emotion affect behavior", "Abnormal enchondral ossification", "Abnormal endocardium morphology", "Abnormal endocrine physiology", "Abnormal enzyme coenzyme activity", "Abnormal eosinophil morphology", "Abnormal epidermal morphology", "Abnormal epiglottis morphology", "Abnormal epiphyseal ossification", "Abnormal epiphysis morphology of the phalanges of the hand", "Abnormal erythrocyte enzyme level", "Abnormal erythrocyte morphology", "Abnormal erythrocyte physiology", "Abnormal erythrocyte sedimentation rate", "Abnormal esophagus morphology", "Abnormal esophagus physiology", "Abnormal external genitalia", "Abnormal exteroceptive sensation", "Abnormal eyebrow morphology", "Abnormal eyelash morphology", "Abnormal eyelid morphology", "Abnormal eyelid physiology", "Abnormal facial expression", "Abnormal facial shape", "Abnormal factor ix activity", "Abnormal fallopian tube morphology", "Abnormal fear anxiety related behavior", "Abnormal female reproductive system physiology", "Abnormal femoral head morphology", "Abnormal femoral neck head morphology", "Abnormal femoral neck morphology", "Abnormal finger phalanx morphology", "Abnormal fingernail morphology", "Abnormal fingertip morphology", "Abnormal foot bone ossification", "Abnormal foramen magnum morphology", "Abnormal forearm bone morphology", "Abnormal form of the vertebral bodies", "Abnormal foveal morphology", "Abnormal full field electroretinogram", "Abnormal fundus autofluorescence imaging", "Abnormal gallbladder morphology", "Abnormal gastrointestinal motility", "Abnormal glial cell morphology", "Abnormal globus pallidus morphology", "Abnormal glomerular basement membrane morphology", "Abnormal glomerular filtration rate", "Abnormal glomerular mesangial cellularity", "Abnormal glomerular mesangium morphology", "Abnormal glucose homeostasis", "Abnormal glycosylation", "Abnormal granulocyte count", "Abnormal granulocytopoietic cell morphology", "Abnormal greater sciatic notch morphology", "Abnormal growth hormone level", "Abnormal hair laboratory examination", "Abnormal hair morphology", "Abnormal hair pattern", "Abnormal hair quantity", "Abnormal hair whorl", "Abnormal hand bone ossification", "Abnormal hand morphology", "Abnormal hdl cholesterol concentration", "Abnormal head movements", "Abnormal heart rate variability", "Abnormal heart sound", "Abnormal heart valve morphology", "Abnormal heart valve physiology", "Abnormal hemoglobin", "Abnormal hemoglobin concentration", "Abnormal hepatic iron concentration", "Abnormal humerus morphology", "Abnormal hypothalamus morphology", "Abnormal hypothalamus physiology", "Abnormal ileum morphology", "Abnormal iliac wing morphology", "Abnormal ilium morphology", "Abnormal immune system morphology", "Abnormal incisor morphology", "Abnormal inflammatory response", "Abnormal insulin level", "Abnormal internal genitalia", "Abnormal intestine morphology", "Abnormal intraocular pressure", "Abnormal involuntary eye movements", "Abnormal iris pigmentation", "Abnormal jaw morphology", "Abnormal joint morphology", "Abnormal labia majora morphology", "Abnormal labia minora morphology", "Abnormal labia morphology", "Abnormal lacrimal duct morphology", "Abnormal lacrimal gland morphology", "Abnormal lactate dehydrogenase level", "Abnormal large intestine morphology", "Abnormal large intestine physiology", "Abnormal larynx morphology", "Abnormal larynx physiology", "Abnormal lateral ventricle morphology", "Abnormal ldl cholesterol concentration", "Abnormal left atrium morphology", "Abnormal left ventricle morphology", "Abnormal left ventricular outflow tract morphology", "Abnormal length of corpus callosum", "Abnormal leukocyte count", "Abnormal leukocyte physiology", "Abnormal levels of alpha fetoprotein", "Abnormal libido", "Abnormal light and dark adapted electroretinogram", "Abnormal lip morphology", "Abnormal liver morphology", "Abnormal liver parenchyma morphology", "Abnormal liver physiology", "Abnormal localization of kidney", "Abnormal location of ears", "Abnormal lower limb bone morphology", "Abnormal lower motor neuron morphology", "Abnormal lumbar spine morphology", "Abnormal lung development", "Abnormal lung lobation", "Abnormal lymphatic vessel morphology", "Abnormal lymphocyte morphology", "Abnormal macrophage morphology", "Abnormal macroscopic urine appearance", "Abnormal macular morphology", "Abnormal magnesium concentration", "Abnormal male reproductive system physiology", "Abnormal mandibular ramus morphology", "Abnormal mast cell morphology", "Abnormal mean corpuscular hemoglobin concentration", "Abnormal mean corpuscular volume", "Abnormal megakaryocyte morphology", "Abnormal meningeal morphology", "Abnormal metabolic brain imaging by mrs", "Abnormal metabolism", "Abnormal metacarpal morphology", "Abnormal metaphyseal trabeculation", "Abnormal metatarsal morphology", "Abnormal midbrain morphology", "Abnormal middle phalanx morphology of the hand", "Abnormal mitochondria in muscle tissue", "Abnormal mitochondrial morphology", "Abnormal mitochondrial shape", "Abnormal mitral valve physiology", "Abnormal monocyte morphology", "Abnormal morphology of myocardial trabeculae", "Abnormal morphology of the abdominal musculature", "Abnormal morphology of the choroidal vasculature", "Abnormal morphology of the conjunctival vasculature", "Abnormal morphology of the great vessels", "Abnormal morphology of the limbic system", "Abnormal morphology of the musculature of the neck", "Abnormal morphology of the olfactory bulb", "Abnormal morphology of the radius", "Abnormal motor evoked potentials", "Abnormal motor nerve conduction velocity", "Abnormal muscle fiber morphology", "Abnormal muscle fiber protein expression", "Abnormal muscle fiber type distribution", "Abnormal muscle glycogen content", "Abnormal myelination", "Abnormal myeloid cell morphology", "Abnormal myeloid leukocyte morphology", "Abnormal myocardium morphology", "Abnormal nasal base", "Abnormal nasal bridge morphology", "Abnormal nasal mucosa morphology", "Abnormal nasolacrimal system morphology", "Abnormal natural killer cell morphology", "Abnormal natural killer cell physiology", "Abnormal nephron morphology", "Abnormal nerve conduction velocity", "Abnormal nervous system electrophysiology", "Abnormal neural tube morphology", "Abnormal neuron morphology", "Abnormal neutrophil count", "Abnormal nipple morphology", "Abnormal number of erythroid precursors", "Abnormal number of granulocyte precursors", "Abnormal number of incisors", "Abnormal number of teeth", "Abnormal odontoid tissue morphology", "Abnormal optical coherence tomography", "Abnormal oral frenulum morphology", "Abnormal oral glucose tolerance", "Abnormal oral mucosa morphology", "Abnormal oral physiology", "Abnormal ossification involving the femoral head and neck", "Abnormal ovarian morphology", "Abnormal ovarian physiology", "Abnormal palate morphology", "Abnormal palmar dermatoglyphics", "Abnormal pancreas morphology", "Abnormal pancreas size", "Abnormal paranasal sinus morphology", "Abnormal parietal bone morphology", "Abnormal parotid gland morphology", "Abnormal patella morphology", "Abnormal pattern of respiration", "Abnormal pelvis bone morphology", "Abnormal pelvis bone ossification", "Abnormal penis morphology", "Abnormal pericardium morphology", "Abnormal peripheral action potential amplitude", "Abnormal peripheral myelination", "Abnormal peripheral nervous system morphology", "Abnormal peripheral nervous system physiology", "Abnormal peristalsis", "Abnormal periventricular white matter morphology", "Abnormal phalangeal joint morphology of the hand", "Abnormal pharynx morphology", "Abnormal pigmentation of the oral mucosa", "Abnormal pineal morphology", "Abnormal placenta morphology", "Abnormal placental membrane morphology", "Abnormal placental size", "Abnormal platelet aggregation", "Abnormal platelet function", "Abnormal platelet granules", "Abnormal platelet morphology", "Abnormal platelet volume", "Abnormal pleura morphology", "Abnormal pons morphology", "Abnormal posterior segment imaging", "Abnormal pr interval", "Abnormal preputium morphology", "Abnormal prolactin level", "Abnormal proportion of cd4 positive t cells", "Abnormal proportion of cd8 positive t cells", "Abnormal proportion of class switched memory b cells", "Abnormal proportion of double negative alpha beta regulatory t cell", "Abnormal prostate morphology", "Abnormal protein glycosylation", "Abnormal protein o linked glycosylation", "Abnormal proximal phalanx morphology of the hand", "Abnormal pulmonary interstitial morphology", "Abnormal pulmonary thoracic imaging finding", "Abnormal pulmonary valve morphology", "Abnormal pulmonary valve physiology", "Abnormal pupil morphology", "Abnormal pupillary function", "Abnormal pupillary light reflex", "Abnormal pyramidal sign", "Abnormal qrs complex", "Abnormal qt interval", "Abnormal rectum morphology", "Abnormal reflex", "Abnormal renal collecting system morphology", "Abnormal renal cortex morphology", "Abnormal renal corticomedullary differentiation", "Abnormal renal echogenicity", "Abnormal renal insterstitial morphology", "Abnormal renal medulla morphology", "Abnormal renal morphology", "Abnormal renal pelvis morphology", "Abnormal renal physiology", "Abnormal renal resorption", "Abnormal renal tubule morphology", "Abnormal renal vascular morphology", "Abnormal respiratory motile cilium morphology", "Abnormal respiratory motile cilium physiology", "Abnormal respiratory system morphology", "Abnormal response to acth stimulation test", "Abnormal response to endocrine stimulation test", "Abnormal response to insulin tolerance test", "Abnormal reticulocyte morphology", "Abnormal retinal artery morphology", "Abnormal retinal morphology", "Abnormal retinal vascular morphology", "Abnormal rib cage morphology", "Abnormal rib ossification", "Abnormal right atrium morphology", "Abnormal right ventricle morphology", "Abnormal saccadic eye movements", "Abnormal sacroiliac joint morphology", "Abnormal sacrum morphology", "Abnormal salivary gland morphology", "Abnormal sarcomere morphology", "Abnormal scalp morphology", "Abnormal scapula morphology", "Abnormal sclera morphology", "Abnormal scrotal rugation", "Abnormal sella turcica morphology", "Abnormal sensory nerve conduction velocity", "Abnormal serum insulin like growth factor 1 level", "Abnormal serum interferon level", "Abnormal serum interleukin level", "Abnormal serum iron concentration", "Abnormal sex determination", "Abnormal shape of the frontal region", "Abnormal shape of the occiput", "Abnormal shape of the palpebral fissure", "Abnormal sharpey fiber morphology", "Abnormal shoulder morphology", "Abnormal shoulder physiology", "Abnormal size of pituitary gland", "Abnormal size of the clitoris", "Abnormal size of the palpebral fissures", "Abnormal skin morphology of the palm", "Abnormal social behavior", "Abnormal soft palate morphology", "Abnormal speech prosody", "Abnormal sperm motility", "Abnormal spermatogenesis", "Abnormal spinal meningeal morphology", "Abnormal sputum", "Abnormal sternal ossification", "Abnormal sternum morphology", "Abnormal stomach morphology", "Abnormal stool composition", "Abnormal subarachnoid space morphology", "Abnormal subclavian artery morphology", "Abnormal subcutaneous fat tissue distribution", "Abnormal substantia nigra morphology", "Abnormal superior cerebellar peduncle morphology", "Abnormal sweat gland morphology", "Abnormal synaptic transmission at the neuromuscular junction", "Abnormal systemic arterial morphology", "Abnormal systemic blood pressure", "Abnormal t cell activation", "Abnormal t cell morphology", "Abnormal t cell proliferation", "Abnormal t cell subset distribution", "Abnormal t wave", "Abnormal talus morphology", "Abnormal temper tantrums", "Abnormal temporal bone morphology", "Abnormal tendon morphology", "Abnormal testis morphology", "Abnormal thalamic mri signal intensity", "Abnormal thalamic size", "Abnormal thoracic spine morphology", "Abnormal thorax morphology", "Abnormal thrombocyte morphology", "Abnormal thrombosis", "Abnormal thumb morphology", "Abnormal thyroid hormone level", "Abnormal thyroid morphology", "Abnormal thyroid stimulating hormone level", "Abnormal tissue metabolite concentration", "Abnormal toenail morphology", "Abnormal tongue morphology", "Abnormal tongue physiology", "Abnormal trabecular bone morphology", "Abnormal tracheal morphology", "Abnormal tracheobronchial morphology", "Abnormal transferrin saturation", "Abnormal tricuspid valve morphology", "Abnormal tricuspid valve physiology", "Abnormal umbilicus morphology", "Abnormal upper limb bone morphology", "Abnormal upper motor neuron morphology", "Abnormal ureter morphology", "Abnormal ureter physiology", "Abnormal urinary color", "Abnormal urinary electrolyte concentration", "Abnormal urine alpha ketoglutarate concentration", "Abnormal urine carbohydrate level", "Abnormal urine carboxylic acid level", "Abnormal urine cytology", "Abnormal urine hormone level", "Abnormal urine magnesium concentration", "Abnormal urine metabolite level", "Abnormal urine ph", "Abnormal urine phosphate concentration", "Abnormal urine potassium concentration", "Abnormal urine protein level", "Abnormal urine sodium concentration", "Abnormal uterus morphology", "Abnormal uvea morphology", "Abnormal uvula morphology", "Abnormal vagina morphology", "Abnormal vascular morphology", "Abnormal vascular physiology", "Abnormal vena cava morphology", "Abnormal venous morphology", "Abnormal ventricular septum morphology", "Abnormal vertebral morphology", "Abnormal vertebral segmentation and fusion", "Abnormal vestibulo ocular reflex", "Abnormal visual electrophysiology", "Abnormal visual field test", "Abnormal visual fixation", "Abnormal vitamin b12 level", "Abnormal vitreous humor morphology", "Abnormal waist to hip ratio", "Abnormal z disc morphology", "Abnormalities of placenta or umbilical cord", "Abnormality iris morphology", "Abnormality of abdominal situs", "Abnormality of acid base homeostasis", "Abnormality of adrenal morphology", "Abnormality of adrenal physiology", "Abnormality of alkaline phosphatase level", "Abnormality of amino acid metabolism", "Abnormality of bladder morphology", "Abnormality of blood circulation", "Abnormality of blood volume homeostasis", "Abnormality of body mass index", "Abnormality of bone marrow cell morphology", "Abnormality of bone mineral density", "Abnormality of canine", "Abnormality of cardiovascular system electrophysiology", "Abnormality of carpal bone ossification", "Abnormality of cartilage of external ear", "Abnormality of central nervous system electrophysiology", "Abnormality of chorioretinal pigmentation", "Abnormality of chromosome segregation", "Abnormality of chromosome stability", "Abnormality of circulating adrenocorticotropin level", "Abnormality of circulating enzyme level", "Abnormality of circulating fibrinogen", "Abnormality of circulating glucocorticoid level", "Abnormality of circulating leptin level", "Abnormality of coagulation", "Abnormality of complement system", "Abnormality of coordination", "Abnormality of corneal size", "Abnormality of corneal stroma", "Abnormality of corneal thickness", "Abnormality of cranial sutures", "Abnormality of dental color", "Abnormality of dental eruption", "Abnormality of dental morphology", "Abnormality of dental structure", "Abnormality of dermal melanosomes", "Abnormality of digestive system morphology", "Abnormality of dna repair", "Abnormality of earlobe", "Abnormality of endocrine pancreas physiology", "Abnormality of epiphysis morphology", "Abnormality of exocrine pancreas physiology", "Abnormality of extrapyramidal motor function", "Abnormality of facial adipose tissue", "Abnormality of facial musculature", "Abnormality of facial skeleton", "Abnormality of facial soft tissue", "Abnormality of female external genitalia", "Abnormality of femur morphology", "Abnormality of fibula morphology", "Abnormality of finger", "Abnormality of fluid regulation", "Abnormality of folate metabolism", "Abnormality of fontanelles", "Abnormality of foveal pigmentation", "Abnormality of frontal sinus", "Abnormality of fundus pigmentation", "Abnormality of globe location", "Abnormality of globe size", "Abnormality of glycolipid metabolism", "Abnormality of hair growth", "Abnormality of hair pigmentation", "Abnormality of hair texture", "Abnormality of hand joint mobility", "Abnormality of head blood vessel", "Abnormality of hepatobiliary system physiology", "Abnormality of hindbrain morphology", "Abnormality of humoral immunity", "Abnormality of immune serum protein physiology", "Abnormality of iron homeostasis", "Abnormality of krebs cycle metabolism", "Abnormality of limb epiphysis morphology", "Abnormality of lipoprotein cholesterol concentration", "Abnormality of long bone morphology", "Abnormality of lower limb epiphysis morphology", "Abnormality of lower limb joint", "Abnormality of lower limb metaphyses", "Abnormality of lower lip", "Abnormality of lysosomal metabolism", "Abnormality of macular pigmentation", "Abnormality of malar bones", "Abnormality of male internal genitalia", "Abnormality of metacarpal epiphyses", "Abnormality of metacarpophalangeal joint", "Abnormality of mouth shape", "Abnormality of mouth size", "Abnormality of muscle size", "Abnormality of nail color", "Abnormality of neuronal migration", "Abnormality of neutrophil morphology", "Abnormality of neutrophil physiology", "Abnormality of neutrophils", "Abnormality of ocular smooth pursuit", "Abnormality of pain sensation", "Abnormality of pancreas physiology", "Abnormality of pelvic girdle bone morphology", "Abnormality of periauricular region", "Abnormality of peripheral nerves", "Abnormality of prenatal development or birth", "Abnormality of primary teeth", "Abnormality of prothrombin", "Abnormality of pulmonary circulation", "Abnormality of refraction", "Abnormality of renal excretion", "Abnormality of renin angiotensin system", "Abnormality of reproductive system physiology", "Abnormality of retinal pigmentation", "Abnormality of salivation", "Abnormality of secondary sexual hair", "Abnormality of skeletal maturation", "Abnormality of skeletal muscle fiber size", "Abnormality of skin adnexa physiology", "Abnormality of skin physiology", "Abnormality of skin pigmentation", "Abnormality of skull ossification", "Abnormality of small intestinal villus morphology", "Abnormality of somatosensory evoked potentials", "Abnormality of subcutaneous fat tissue", "Abnormality of t cell physiology", "Abnormality of taste sensation", "Abnormality of temperature regulation", "Abnormality of thalamus morphology", "Abnormality of the 1st metacarpal", "Abnormality of the 2nd toe", "Abnormality of the 3rd toe", "Abnormality of the 4th metacarpal", "Abnormality of the 5th metacarpal", "Abnormality of the 5th toe", "Abnormality of the abdominal organs", "Abnormality of the abdominal wall", "Abnormality of the achilles tendon", "Abnormality of the adrenal glands", "Abnormality of the alveolar ridges", "Abnormality of the amniotic fluid", "Abnormality of the ankles", "Abnormality of the anterior fontanelle", "Abnormality of the antihelix", "Abnormality of the antitragus", "Abnormality of the anus", "Abnormality of the auditory canal", "Abnormality of the autonomic nervous system", "Abnormality of the axillary hair", "Abnormality of the basal ganglia", "Abnormality of the biliary system", "Abnormality of the bladder", "Abnormality of the brainstem white matter", "Abnormality of the breast", "Abnormality of the calcaneus", "Abnormality of the calf", "Abnormality of the calf musculature", "Abnormality of the calvaria", "Abnormality of the carpal bones", "Abnormality of the cerebral subcortex", "Abnormality of the cerebrospinal fluid", "Abnormality of the cervical spine", "Abnormality of the cheek", "Abnormality of the chin", "Abnormality of the choanae", "Abnormality of the clitoris", "Abnormality of the coagulation cascade", "Abnormality of the columella", "Abnormality of the common coagulation pathway", "Abnormality of the costochondral junction", "Abnormality of the crus of the helix", "Abnormality of the curvature of the cornea", "Abnormality of the curvature of the vertebral column", "Abnormality of the dentition", "Abnormality of the diaphragm", "Abnormality of the diencephalon", "Abnormality of the distal phalanges of the toes", "Abnormality of the distal phalanx of the thumb", "Abnormality of the dorsal column of the spinal cord", "Abnormality of the elbow", "Abnormality of the endometrium", "Abnormality of the epididymis", "Abnormality of the epiphyses of the distal phalanx of finger", "Abnormality of the external nose", "Abnormality of the extraocular muscles", "Abnormality of the extrinsic pathway", "Abnormality of the female genitalia", "Abnormality of the fetal cardiovascular system", "Abnormality of the fifth metatarsal bone", "Abnormality of the fontanelles or cranial sutures", "Abnormality of the foot musculature", "Abnormality of the forearm", "Abnormality of the forehead", "Abnormality of the frontal hairline", "Abnormality of the gallbladder", "Abnormality of the gastric mucosa", "Abnormality of the gingiva", "Abnormality of the glabella", "Abnormality of the glenoid fossa", "Abnormality of the hairline", "Abnormality of the hallux", "Abnormality of the helix", "Abnormality of the hepatic vasculature", "Abnormality of the humeroradial joint", "Abnormality of the humerus", "Abnormality of the hypothalamus pituitary axis", "Abnormality of the hypothenar eminence", "Abnormality of the incisor", "Abnormality of the inner ear", "Abnormality of the internal auditory canal", "Abnormality of the intervertebral disk", "Abnormality of the intrahepatic bile duct", "Abnormality of the intrinsic pathway", "Abnormality of the kidney", "Abnormality of the knee", "Abnormality of the larynx", "Abnormality of the lens", "Abnormality of the leydig cells", "Abnormality of the liver", "Abnormality of the lower urinary tract", "Abnormality of the lymph nodes", "Abnormality of the lymphatic system", "Abnormality of the mastoid", "Abnormality of the maxilla", "Abnormality of the menstrual cycle", "Abnormality of the metacarpal bones", "Abnormality of the metaphysis", "Abnormality of the metopic suture", "Abnormality of the middle ear", "Abnormality of the middle ear ossicles", "Abnormality of the middle phalanx of the 5th finger", "Abnormality of the midface", "Abnormality of the mitochondrion", "Abnormality of the musculature of the hand", "Abnormality of the musculature of the limbs", "Abnormality of the musculature of the lower limbs", "Abnormality of the musculature of the thigh", "Abnormality of the musculature of the upper arm", "Abnormality of the musculature of the upper limbs", "Abnormality of the nail", "Abnormality of the nasal alae", "Abnormality of the nasal bone", "Abnormality of the nasal cavity", "Abnormality of the nasal dorsum", "Abnormality of the nasal septum", "Abnormality of the nasal skeleton", "Abnormality of the nasal tip", "Abnormality of the nasolabial region", "Abnormality of the neck", "Abnormality of the odontoid process", "Abnormality of the optic nerve", "Abnormality of the outer ear", "Abnormality of the ovary", "Abnormality of the palm", "Abnormality of the palpebral fissures", "Abnormality of the pancreas", "Abnormality of the parathyroid gland", "Abnormality of the parathyroid morphology", "Abnormality of the periorbital region", "Abnormality of the peripheral nervous system", "Abnormality of the peritoneum", "Abnormality of the periungual region", "Abnormality of the phalanges of the toes", "Abnormality of the pharynx", "Abnormality of the philtrum", "Abnormality of the pineal gland", "Abnormality of the pinna", "Abnormality of the pituitary gland", "Abnormality of the plantar skin of foot", "Abnormality of the posterior pituitary", "Abnormality of the protein c anticoagulant pathway", "Abnormality of the proximal phalanx of the thumb", "Abnormality of the pubic bone", "Abnormality of the pubic hair", "Abnormality of the pulmonary artery", "Abnormality of the pulmonary vasculature", "Abnormality of the pulmonary veins", "Abnormality of the pylorus", "Abnormality of the radial head", "Abnormality of the radioulnar joints", "Abnormality of the ribs", "Abnormality of the scrotum", "Abnormality of the sense of smell", "Abnormality of the septum pellucidum", "Abnormality of the shoulder girdle musculature", "Abnormality of the skull base", "Abnormality of the small intestine", "Abnormality of the spinal cord", "Abnormality of the spleen", "Abnormality of the stapes", "Abnormality of the subungual region", "Abnormality of the supraorbital ridges", "Abnormality of the synovia", "Abnormality of the tarsal bones", "Abnormality of the temporomandibular joint", "Abnormality of the testis size", "Abnormality of the thenar eminence", "Abnormality of the thoracic cavity", "Abnormality of the thymus", "Abnormality of the thyroid gland", "Abnormality of the tongue", "Abnormality of the tonsils", "Abnormality of the tragus", "Abnormality of the ulna", "Abnormality of the umbilical cord", "Abnormality of the upper arm", "Abnormality of the upper respiratory tract", "Abnormality of the ureter", "Abnormality of the urethra", "Abnormality of the urinary system physiology", "Abnormality of the uterus", "Abnormality of the vasculature of the eye", "Abnormality of the vertebral endplates", "Abnormality of the vestibulocochlear nerve", "Abnormality of the voice", "Abnormality of the wrist", "Abnormality of the zygomatic bone", "Abnormality of thyroid physiology", "Abnormality of tibia morphology", "Abnormality of toe", "Abnormality of ulnar metaphysis", "Abnormality of upper limb epiphysis morphology", "Abnormality of upper limb joint", "Abnormality of upper limb metaphysis", "Abnormality of upper lip", "Abnormality of upper lip vermillion", "Abnormality of urinary uric acid concentration", "Abnormality of urine calcium concentration", "Abnormality of urine catecholamine concentration", "Abnormality of urine homeostasis", "Abnormality of visual evoked potentials", "Abnormality of vitamin a metabolism", "Abnormality of vitamin b metabolism", "Abnormality of vitamin b12 metabolism", "Abnormality of vitamin d metabolism", "Abnormality of vitamin e metabolism", "Abnormality of vitamin k metabolism", "Abnormality of vitamin metabolism", "Abnormality on pulmonary function testing", "Abnormally folded helix", "Abnormally large globe", "Abnormally lax or hyperextensible skin", "Abnormally low pitched voice", "Abnormally ossified vertebrae", "Abnormally shaped carpal bones", "Abscess", "Absence of pubertal development", "Absence of secondary sex characteristics", "Absence of subcutaneous fat", "Absent axillary hair", "Absent brainstem auditory responses", "Absent distal phalanges", "Absent earlobe", "Absent epiphyses", "Absent eyebrow", "Absent facial hair", "Absent fingernail", "Absent forearm bone", "Absent foveal reflex", "Absent frontal sinuses", "Absent hair", "Absent hypoplastic paranasal sinuses", "Absent nares", "Absent nipple", "Absent or minimally ossified vertebral bodies", "Absent outer dynein arms", "Absent palmar crease", "Absent septum pellucidum", "Absent shortened dynein arms", "Absent speech", "Absent sternal ossification", "Absent testis", "Absent thumb", "Absent thumbnail", "Absent toe", "Absent toenail", "Acanthocytosis", "Acantholysis", "Acanthosis nigricans", "Accelerated atherosclerosis", "Accelerated skeletal maturation", "Accessory oral frenulum", "Accessory spleen", "Acetabular dysplasia", "Achilles tendon contracture", "Acidemia", "Acne", "Acne inversa", "Acquired abnormal hair pattern", "Acral blistering", "Acral ulceration", "Acromesomelia", "Acromicria", "Acroparesthesia", "Action tremor", "Acute coronary syndrome", "Acute encephalopathy", "Acute hepatic failure", "Acute kidney injury", "Acute leukemia", "Acute lymphoblastic leukemia", "Acute myeloid leukemia", "Acute pancreatitis", "Acute phase response", "Addictive behavior", "Adducted thumb", "Adenocarcinoma of the colon", "Adenocarcinoma of the intestines", "Adenocarcinoma of the small intestine", "Adenoma sebaceum", "Adenomatous colonic polyposis", "Adipose tissue loss", "Adrenal hyperplasia", "Adrenal hypoplasia", "Adrenal insufficiency", "Adrenal overactivity", "Adrenocortical abnormality", "Adrenocortical carcinoma", "Adrenocorticotropic hormone deficiency", "Adrenocorticotropic hormone excess", "Adrenocorticotropin deficient adrenal insufficiency", "Adult onset", "Adult onset sensorineural hearing impairment", "Advanced eruption of teeth", "Agammaglobulinemia", "Aganglionic megacolon", "Agenesis of central incisor", "Agenesis of cerebellar vermis", "Agenesis of corpus callosum", "Agenesis of incisor", "Agenesis of lateral incisor", "Agenesis of maxillary incisor", "Aggressive behavior", "Agitation", "Agnosia", "Agyria", "Airway obstruction", "Akinesia", "Alacrima", "Albinism", "Albuminuria", "Alexia", "Alkalosis", "Allergic rhinitis", "Allergy", "Alopecia", "Alopecia of scalp", "Alopecia totalis", "Alopecia universalis", "Alternating esotropia", "Alveolar rhabdomyosarcoma", "Alveolar ridge overgrowth", "Alzheimer disease", "Amaurosis fugax", "Ambiguous genitalia", "Ambiguous genitalia female", "Ambiguous genitalia male", "Amblyopia", "Amegakaryocytic thrombocytopenia", "Amelogenesis imperfecta", "Amenorrhea", "Aminoaciduria", "Amniotic constriction ring", "Amyloidosis", "Amyotrophic lateral sclerosis", "Anal atresia", "Anal fissure", "Anal stenosis", "Anaphylactic shock", "Anarthria", "Anasarca", "Anemia of inadequate production", "Anencephaly", "Angina pectoris", "Angioedema", "Angiofibromas", "Angioid streaks of the fundus", "Angiokeratoma", "Angular cheilitis", "Anhidrosis", "Aniridia", "Anisocoria", "Anisocytosis", "Anisopoikilocytosis", "Anisospondyly", "Ankle clonus", "Ankle flexion contracture", "Ankle weakness", "Ankyloblepharon", "Ankyloglossia", "Ankylosis", "Annular pancreas", "Anodontia", "Anomalous trichromacy", "Anonychia", "Anophthalmia", "Anorectal anomaly", "Anorexia", "Anosmia", "Anotia", "Antenatal onset", "Anterior chamber synechiae", "Anterior open bite malocclusion", "Anterior pituitary dysgenesis", "Anterior plagiocephaly", "Anterior rib cupping", "Anterior synechiae of the anterior chamber", "Anterior uveitis", "Anteriorly placed anus", "Anteverted ears", "Anti thyroid peroxidase antibody positivity", "Antineutrophil antibody positivity", "Antinuclear antibody positivity", "Antiphospholipid antibody positivity", "Aortic aneurysm", "Aortic arch aneurysm", "Aortic atherosclerotic lesion", "Aortic dissection", "Aortic regurgitation", "Aortic root aneurysm", "Aortic valve calcification", "Aortic valve stenosis", "Aphasia", "Aphthous ulcer", "Aplasia cutis congenita", "Aplasia cutis congenita of scalp", "Aplasia cutis congenita on trunk or limbs", "Aplasia cutis congenita over the scalp vertex", "Aplasia hypoplasia affecting bones of the axial skeleton", "Aplasia hypoplasia affecting the anterior segment of the eye", "Aplasia hypoplasia affecting the eye", "Aplasia hypoplasia affecting the fundus", "Aplasia hypoplasia involving bones of the feet", "Aplasia hypoplasia involving bones of the lower limbs", "Aplasia hypoplasia involving bones of the thorax", "Aplasia hypoplasia involving bones of the upper limbs", "Aplasia hypoplasia involving forearm bones", "Aplasia hypoplasia involving the carpal bones", "Aplasia hypoplasia involving the femoral head and neck", "Aplasia hypoplasia involving the metacarpal bones", "Aplasia hypoplasia involving the musculature of the upper limbs", "Aplasia hypoplasia involving the nose", "Aplasia hypoplasia involving the pelvis", "Aplasia hypoplasia involving the sinuses", "Aplasia hypoplasia involving the skeletal musculature", "Aplasia hypoplasia involving the skeleton", "Aplasia hypoplasia involving the vertebral column", "Aplasia hypoplasia of fingers", "Aplasia hypoplasia of metatarsal bones", "Aplasia hypoplasia of the 4th metacarpal", "Aplasia hypoplasia of the 5th finger", "Aplasia hypoplasia of the 5th metacarpal", "Aplasia hypoplasia of the abdominal wall musculature", "Aplasia hypoplasia of the bladder", "Aplasia hypoplasia of the breasts", "Aplasia hypoplasia of the capital femoral epiphysis", "Aplasia hypoplasia of the cerebellar vermis", "Aplasia hypoplasia of the cerebellum", "Aplasia hypoplasia of the cerebral white matter", "Aplasia hypoplasia of the clavicles", "Aplasia hypoplasia of the colon", "Aplasia hypoplasia of the distal phalanges of the hand", "Aplasia hypoplasia of the distal phalanx of the thumb", "Aplasia hypoplasia of the ear", "Aplasia hypoplasia of the earlobes", "Aplasia hypoplasia of the epiglottis", "Aplasia hypoplasia of the extremities", "Aplasia hypoplasia of the eyebrow", "Aplasia hypoplasia of the eyelid", "Aplasia hypoplasia of the femur", "Aplasia hypoplasia of the fibula", "Aplasia hypoplasia of the gallbladder", "Aplasia hypoplasia of the hallux", "Aplasia hypoplasia of the humerus", "Aplasia hypoplasia of the lungs", "Aplasia hypoplasia of the nails", "Aplasia hypoplasia of the nasal bone", "Aplasia hypoplasia of the nasal septum", "Aplasia hypoplasia of the nipples", "Aplasia hypoplasia of the optic nerve", "Aplasia hypoplasia of the ovary", "Aplasia hypoplasia of the palmar creases", "Aplasia hypoplasia of the patella", "Aplasia hypoplasia of the phalanges of the hand", "Aplasia hypoplasia of the phalanges of the thumb", "Aplasia hypoplasia of the phalanges of the toes", "Aplasia hypoplasia of the proximal phalanges of the hand", "Aplasia hypoplasia of the pubic bone", "Aplasia hypoplasia of the radius", "Aplasia hypoplasia of the retina", "Aplasia hypoplasia of the ribs", "Aplasia hypoplasia of the sacrum", "Aplasia hypoplasia of the scapulae", "Aplasia hypoplasia of the skin", "Aplasia hypoplasia of the spleen", "Aplasia hypoplasia of the sternum", "Aplasia hypoplasia of the thumb", "Aplasia hypoplasia of the thymus", "Aplasia hypoplasia of the thyroid gland", "Aplasia hypoplasia of the tibia", "Aplasia hypoplasia of the tongue", "Aplasia hypoplasia of the tragus", "Aplasia hypoplasia of the ulna", "Aplasia hypoplasia of the uterus", "Aplasia hypoplasia of the uvula", "Aplasia hypoplasia of the vagina", "Aplasia hypoplasia of toe", "Aplasia involving bones of the extremities", "Aplasia involving bones of the lower limbs", "Aplasia of the fingers", "Aplasia of the middle phalanx of the hand", "Aplasia of the phalanges of the hand", "Aplasia of the phalanges of the toes", "Aplasia of the uterus", "Aplastic anemia", "Aplastic clavicle", "Aplastic hypoplastic lacrimal glands", "Aplastic hypoplastic toenail", "Apnea", "Apneic episodes precipitated by illness fatigue stress", "Appendicular hypotonia", "Apraxia", "Aqueductal stenosis", "Arachnodactyly", "Arachnoid hemangiomatosis", "Areflexia", "Areflexia of lower limbs", "Arm dystonia", "Arnold chiari malformation", "Arnold chiari type i malformation", "Arrhinencephaly", "Arteria lusoria", "Arterial dissection", "Arterial rupture", "Arterial stenosis", "Arterial thrombosis", "Arteriosclerosis", "Arteriovenous malformation", "Arthralgia", "Arthritis", "Arthrogryposis multiplex congenita", "Arthropathy", "Ascending aortic dissection", "Ascending tubular aorta aneurysm", "Ascites", "Aspiration", "Aspiration pneumonia", "Asterixis", "Asthenia", "Asthma", "Astigmatism", "Astrocytoma", "Astrocytosis", "Asymmetric growth", "Asymmetric septal hypertrophy", "Asymmetry of the ears", "Atelectasis", "Athetosis", "Atlantoaxial abnormality", "Atlantoaxial dislocation", "Atlantoaxial instability", "Atonic seizure", "Atopic dermatitis", "Atresia of the external auditory canal", "Atrial arrhythmia", "Atrial flutter", "Atrioventricular canal defect", "Atrophic scars", "Atrophy degeneration affecting the brainstem", "Atrophy degeneration affecting the central nervous system", "Atrophy degeneration affecting the cerebrum", "Atrophy degeneration involving the caudate nucleus", "Atrophy degeneration involving the corticospinal tracts", "Atrophy degeneration involving the spinal cord", "Attention deficit hyperactivity disorder", "Attenuation of retinal blood vessels", "Atypical absence seizure", "Auditory hallucinations", "Autism", "Autistic behavior", "Autoamputation", "Autoamputation of digits", "Autoimmune antibody positivity", "Autoimmune hemolytic anemia", "Autoimmune thrombocytopenia", "Autoimmunity", "Autosomal dominant germline de novo mutation", "Avascular necrosis", "Avascular necrosis of the capital femoral epiphysis", "Axial dystonia", "Axial muscle weakness", "Axillary pterygium", "Axonal degeneration", "Axonal degeneration regeneration", "Axonal loss", "Axonal regeneration", "Azoospermia", "B cell lymphoma", "B lymphocytopenia", "Babinski sign", "Back pain", "Bacterial endocarditis", "Barrel shaped chest", "Barrett esophagus", "Basal cell carcinoma", "Basal ganglia calcification", "Basal ganglia cysts", "Basal ganglia gliosis", "Beaded ribs", "Beaking of vertebral bodies", "Bell shaped thorax", "Benign neoplasm of the central nervous system", "Biconcave vertebral bodies", "Bicornuate uterus", "Bifid nasal tip", "Bifid ribs", "Bifid scrotum", "Bifid tongue", "Bifid uterus", "Bifid uvula", "Bilateral cleft lip", "Bilateral cleft lip and palate", "Bilateral cleft palate", "Bilateral coxa valga", "Bilateral cryptorchidism", "Bilateral external ear deformity", "Bilateral microphthalmos", "Bilateral polymicrogyria", "Bilateral ptosis", "Bilateral sensorineural hearing impairment", "Bilateral single transverse palmar creases", "Bilateral talipes equinovarus", "Bilateral tonic clonic seizure", "Bilateral tonic clonic seizure with focal onset", "Bilateral tonic clonic seizure with generalized onset", "Bile duct proliferation", "Biliary atresia", "Biliary cirrhosis", "Biliary tract abnormality", "Biliary tract neoplasm", "Bimanual synkinesia", "Biparietal narrowing", "Bird like facies", "Birth length greater than 97th percentile", "Birth length less than 3rd percentile", "Biventricular hypertrophy", "Bladder diverticulum", "Bladder neoplasm", "Bleeding with minor or no trauma", "Blepharitis", "Blepharophimosis", "Blindness", "Blistering by anatomical location", "Blistering by histological location", "Bloodstream infectious agent", "Bloody diarrhea", "Blue irides", "Blue nevus", "Blue sclerae", "Blurred vision", "Bone cyst", "Bone fracture", "Bone marrow foam cells", "Bone marrow hypercellularity", "Bone marrow hypocellularity", "Bone pain", "Bone spicule pigmentation of the retina", "Bowel diverticulosis", "Bowing of the arm", "Bowing of the legs", "Brachycephaly", "Brachydactyly", "Brachyturricephaly", "Bradycardia", "Bradykinesia", "Brain imaging abnormality", "Brain neoplasm", "Brain stem compression", "Branchial anomaly", "Branchial cyst", "Branchial fistula", "Breast aplasia", "Breast carcinoma", "Breast hypoplasia", "Breathing dysregulation", "Breech presentation", "Brisk reflexes", "Brittle hair", "Broad alveolar ridges", "Broad based gait", "Broad chin", "Broad clavicles", "Broad columella", "Broad distal phalanx of finger", "Broad eyebrow", "Broad face", "Broad femoral neck", "Broad finger", "Broad foot", "Broad forehead", "Broad jaw", "Broad long bones", "Broad metacarpals", "Broad nail", "Broad nasal tip", "Broad neck", "Broad palm", "Broad philtrum", "Broad ribs", "Broad thumb", "Broad toe", "Bronchiectasis", "Bronchitis", "Bronchomalacia", "Bronchospasm", "Bruising susceptibility", "Brushfield spots", "Bruxism", "Bulbar palsy", "Bulbar signs", "Bulbous nose", "Bull s eye maculopathy", "Bundle branch block", "Burkitt lymphoma", "Butterfly vertebrae", "Cachexia", "Caesarian section", "Cafe au lait spot", "Calcific stippling", "Calcification of the aorta", "Calcinosis", "Calcium nephrolithiasis", "Calcium oxalate nephrolithiasis", "Calvarial hyperostosis", "Calvarial osteosclerosis", "Calvarial skull defect", "Camptodactyly of toe", "Capillary hemangioma", "Capillary malformation", "Capitate hamate fusion", "Carcinoid tumor", "Carcinoma", "Cardiac arrest", "Cardiac conduction abnormality", "Cardiac diverticulum", "Cardiac rhabdomyoma", "Cardiac shunt", "Cardiac valve calcification", "Cardiomegaly", "Cardiorespiratory arrest", "Cardiovascular calcification", "Carious teeth", "Carpal bone hypoplasia", "Carpal synostosis", "Cataplexy", "Caudate atrophy", "Cavernous hemangioma", "Cavum septum pellucidum", "Celiac disease", "Cellular immunodeficiency", "Cellulitis", "Central adrenal insufficiency", "Central apnea", "Central diabetes insipidus", "Central heterochromia", "Central hypothyroidism", "Central hypoventilation", "Central nervous system cyst", "Central opacification of the cornea", "Central primitive neuroectodermal tumor", "Central scotoma", "Central sleep apnea", "Centrally nucleated skeletal muscle fibers", "Centrocecal scotoma", "Cerebellar atrophy", "Cerebellar cortical atrophy", "Cerebellar cyst", "Cerebellar dysplasia", "Cerebellar hemorrhage", "Cerebellar hypoplasia", "Cerebellar malformation", "Cerebellar vermis atrophy", "Cerebral amyloid angiopathy", "Cerebral calcification", "Cerebral cortical atrophy", "Cerebral dysmyelination", "Cerebral edema", "Cerebral hamartoma", "Cerebral hemorrhage", "Cerebral hypomyelination", "Cerebral hypoplasia", "Cerebral inclusion bodies", "Cerebral palsy", "Cerebral venous thrombosis", "Cerebral visual impairment", "Cerebral white matter atrophy", "Cerebral white matter hypoplasia", "Cervical kyphosis", "Cervical myelopathy", "Cervical ribs", "Cervical spinal canal stenosis", "Cervical spine instability", "Cervical subluxation", "Cessation of head growth", "Cheilitis", "Cherry red spot of the macula", "Chest pain", "Chilblains", "Childhood onset", "Childhood onset sensorineural hearing impairment", "Childhood onset truncal obesity", "Chills", "Choanal stenosis", "Choking episodes", "Cholangitis", "Cholecystitis", "Cholestasis", "Cholestatic liver disease", "Chondrocalcinosis", "Chondrosarcoma", "Chordee", "Chorea", "Choreoathetosis", "Choriocarcinoma", "Chorioretinal atrophy", "Chorioretinal coloboma", "Chorioretinal degeneration", "Chorioretinal dysplasia", "Chorioretinal dystrophy", "Chorioretinal hypopigmentation", "Choroid plexus carcinoma", "Choroid plexus cyst", "Choroidal melanoma", "Choroidal neovascularization", "Chromosomal breakage induced by crosslinking agents", "Chromosomal breakage induced by ionizing radiation", "Chromosome breakage", "Chronic atrophic gastritis", "Chronic axonal neuropathy", "Chronic bronchitis", "Chronic constipation", "Chronic diarrhea", "Chronic fatigue", "Chronic hemolytic anemia", "Chronic hepatic failure", "Chronic infection", "Chronic kidney disease", "Chronic leukemia", "Chronic lung disease", "Chronic lymphatic leukemia", "Chronic mucocutaneous candidiasis", "Chronic neutropenia", "Chronic noninfectious lymphadenopathy", "Chronic oral candidiasis", "Chronic otitis media", "Chronic pulmonary obstruction", "Chronic rhinitis", "Chronic sinusitis", "Chylothorax", "Cirrhosis", "Cleft hard palate", "Cleft lip", "Cleft soft palate", "Cleft upper lip", "Clinodactyly", "Clitoral hypoplasia", "Clonic seizure", "Clonus", "Cloverleaf skull", "Clubbing", "Clubbing of fingers", "Clubbing of toes", "Clumsiness", "Cns demyelination", "Cns hypomyelination", "Coarctation of aorta", "Coarse facial features", "Coarse hair", "Cochlear malformation", "Cognitive impairment", "Cogwheel rigidity", "Cold induced muscle cramps", "Colitis", "Collectionism", "Coloboma", "Colon cancer", "Color vision defect", "Color vision test abnormality", "Colorectal polyposis", "Colpocephaly", "Coma", "Combined immunodeficiency", "Communicating hydrocephalus", "Complete atrioventricular canal defect", "Complete duplication of phalanx of hand", "Complex febrile seizure", "Concave nail", "Concave nasal ridge", "Concentric hypertrophic cardiomyopathy", "Cone cone rod dystrophy", "Cone shaped epiphyses of the phalanges of the hand", "Cone shaped epiphysis", "Confetti like hypopigmented macules", "Confusion", "Congenital adrenal hyperplasia", "Congenital bilateral hip dislocation", "Congenital blindness", "Congenital contracture", "Congenital craniofacial dysostosis", "Congenital diaphragmatic hernia", "Congenital hemolytic anemia", "Congenital hepatic fibrosis", "Congenital hip dislocation", "Congenital hypothyroidism", "Congenital ichthyosiform erythroderma", "Congenital localized absence of skin", "Congenital malformation of the great arteries", "Congenital malformation of the left heart", "Congenital malformation of the right heart", "Congenital muscular dystrophy", "Congenital muscular torticollis", "Congenital nonbullous ichthyosiform erythroderma", "Congenital nystagmus", "Congenital onset", "Congenital posterior urethral valve", "Congenital sensorineural hearing impairment", "Congenital stationary night blindness", "Congenital thrombocytopenia", "Congestive heart failure", "Conical tooth", "Conjugated hyperbilirubinemia", "Conjunctival hamartoma", "Connective tissue nevi", "Conspicuously happy disposition", "Constipation", "Constitutional symptom", "Constriction of peripheral visual field", "Contiguous gene syndrome", "Contractures involving the joints of the feet", "Contractures of the joints of the lower limbs", "Contractures of the joints of the upper limbs", "Contractures of the large joints", "Convex nasal ridge", "Coombs positive hemolytic anemia", "Cor pulmonale", "Corneal dystrophy", "Corneal erosion", "Corneal neovascularization", "Corneal opacity", "Corneal scarring", "Corneal ulceration", "Coronal cleft vertebrae", "Coronal craniosynostosis", "Coronary artery atherosclerosis", "Corpus callosum atrophy", "Cortical cataract", "Cortical dysplasia", "Cortical myoclonus", "Cortical thickening of long bone diaphyses", "Corticospinal tract hypoplasia", "Cough", "Coxa valga", "Coxa vara", "Crackles", "Cranial asymmetry", "Cranial hyperostosis", "Cranial nerve compression", "Craniofacial asymmetry", "Craniofacial dysostosis", "Craniofacial hyperostosis", "Craniofacial osteosclerosis", "Craniosynostosis", "Crumpled long bones", "Cryptorchidism", "Csf lymphocytic pleiocytosis", "Csf pleocytosis", "Cubitus valgus", "Cupped ear", "Cupped ribs", "Curly eyelashes", "Curly hair", "Cutaneous abscess", "Cutaneous cyst", "Cutaneous finger syndactyly", "Cutaneous melanoma", "Cutaneous photosensitivity", "Cutaneous syndactyly", "Cutaneous syndactyly of toes", "Cutis laxa", "Cutis marmorata", "Cyanosis", "Cyanotic episode", "Cyclopia", "Cystic hygroma", "Cystic liver disease", "Cystic renal dysplasia", "Cystinuria", "Cystoid macular edema", "Cytochrome c oxidase negative muscle fibers", "Dark urine", "Death in adolescence", "Death in adulthood", "Death in childhood", "Death in infancy", "Decerebrate rigidity", "Decreased absent ankle reflexes", "Decreased activity of mitochondrial complex i", "Decreased activity of mitochondrial complex ii", "Decreased activity of mitochondrial complex iii", "Decreased activity of mitochondrial complex iv", "Decreased activity of nadph oxidase", "Decreased activity of the pyruvate dehydrogenase complex", "Decreased adenosylcobalamin", "Decreased adipose tissue", "Decreased calvarial ossification", "Decreased cd4 cd8 ratio", "Decreased cervical spine flexion due to contractures of posterior cervical muscles", "Decreased circulating acth level", "Decreased circulating aldosterone level", "Decreased circulating androgen concentration", "Decreased circulating antibody level", "Decreased circulating copper concentration", "Decreased circulating cortisol level", "Decreased circulating follicle stimulating hormone concentration", "Decreased circulating gaba concentration", "Decreased circulating gonadotropin concentration", "Decreased circulating iga level", "Decreased circulating igg level", "Decreased circulating igg subclass level", "Decreased circulating level of specific antibody", "Decreased circulating progesterone", "Decreased circulating total iga", "Decreased circulating total igg", "Decreased circulating total igm", "Decreased corneal reflex", "Decreased facial expression", "Decreased fertility", "Decreased fertility in females", "Decreased fertility in males", "Decreased head circumference", "Decreased lacrimation", "Decreased ldl cholesterol concentration", "Decreased libido", "Decreased light and dark adapted electroretinogram amplitude", "Decreased lymphocyte apoptosis", "Decreased lymphocyte proliferation in response to mitogen", "Decreased mean corpuscular volume", "Decreased methylcobalamin", "Decreased methylmalonyl coa mutase activity", "Decreased muscle mass", "Decreased number of large peripheral myelinated nerve fibers", "Decreased number of peripheral myelinated nerve fibers", "Decreased palmar creases", "Decreased patellar reflex", "Decreased plasma carnitine", "Decreased proportion of cd3 positive t cells", "Decreased proportion of cd4 positive helper t cells", "Decreased pulmonary function", "Decreased serum complement c3", "Decreased serum insulin like growth factor 1", "Decreased serum iron", "Decreased size of nerve terminals", "Decreased specific anti polysaccharide antibody level", "Decreased specific antibody response to protein vaccine", "Decreased specific antibody response to vaccination", "Decreased specific pneumococcal antibody level", "Decreased testicular size", "Decreased urine output", "Deep palmar crease", "Deep philtrum", "Deep plantar creases", "Deep set nails", "Deep venous thrombosis", "Deeply set eye", "Defective dna repair after ultraviolet radiation damage", "Defective t cell proliferation", "Deformed rib cage", "Deformed sella turcica", "Deformed tarsal bones", "Degeneration of the lateral corticospinal tracts", "Degeneration of the striatum", "Dehydration", "Delayed ability to roll over", "Delayed ability to sit", "Delayed ability to stand", "Delayed ability to walk", "Delayed closure of the anterior fontanelle", "Delayed cns myelination", "Delayed cranial suture closure", "Delayed epiphyseal ossification", "Delayed eruption of permanent teeth", "Delayed eruption of primary teeth", "Delayed eruption of teeth", "Delayed fine motor development", "Delayed gross motor development", "Delayed menarche", "Delayed myelination", "Delayed ossification of carpal bones", "Delayed puberty", "Delayed social development", "Delirium", "Delusions", "Dementia", "Demyelinating peripheral neuropathy", "Dental crowding", "Dental malocclusion", "Depletion of mitochondrial dna in muscle tissue", "Deposits immunoreactive to beta amyloid protein", "Depressed nasal bridge", "Depressed nasal ridge", "Depressed nasal tip", "Depression", "Dermal atrophy", "Dermal translucency", "Dermatological manifestations of systemic disorders", "Descending aortic dissection", "Desquamation of skin soon after birth", "Developmental cataract", "Developmental glaucoma", "Developmental regression", "Developmental stagnation", "Deviated nasal septum", "Deviation of the 2nd finger", "Deviation of the 3rd finger", "Deviation of the hallux", "Deviation of the hand or of fingers of the hand", "Deviation of the thumb", "Deviation of toes", "Diabetes insipidus", "Dialeptic seizure", "Diaphragmatic eventration", "Diaphragmatic paralysis", "Diaphragmatic weakness", "Diaphyseal sclerosis", "Diaphyseal thickening", "Diarrhea", "Diastasis recti", "Diastema", "Dicarboxylic aciduria", "Difficulty climbing stairs", "Difficulty in tongue movements", "Difficulty running", "Difficulty standing", "Difficulty walking", "Diffuse alveolar hemorrhage", "Diffuse cerebellar atrophy", "Diffuse cerebral atrophy", "Diffuse mesangial sclerosis", "Diffuse palmoplantar hyperkeratosis", "Diffuse white matter abnormalities", "Digenic inheritance", "Dilatation of the cerebral artery", "Dilatation of the ventricular cavity", "Dilated cardiomyopathy", "Dilated fourth ventricle", "Dilated third ventricle", "Dilation of lateral ventricles", "Dilation of virchow robin spaces", "Diminished ability to concentrate", "Diminished motivation", "Diminished movement", "Diplopia", "Disinhibition", "Displacement of the urethral meatus", "Disproportionate short limb short stature", "Disproportionate short stature", "Disproportionate short trunk short stature", "Disproportionate tall stature", "Disseminated intravascular coagulation", "Distal amyotrophy", "Distal arthrogryposis", "Distal joint laxity", "Distal lower limb amyotrophy", "Distal lower limb muscle weakness", "Distal muscle weakness", "Distal peripheral sensory neuropathy", "Distal sensory impairment", "Distal sensory impairment of all modalities", "Distal sensory loss of all modalities", "Distal upper limb amyotrophy", "Distal upper limb muscle weakness", "Disturbance of facial expression", "Dolichocephaly", "Double aortic arch", "Down sloping shoulders", "Downslanted palpebral fissures", "Downturned corners of mouth", "Drowsiness", "Drusen", "Dry hair", "Dry skin", "Duodenal adenocarcinoma", "Duodenal atresia", "Duodenal stenosis", "Duplicated collecting system", "Duplication involving bones of the feet", "Duplication of hand bones", "Duplication of the distal phalanx of hand", "Duplication of thumb phalanx", "Dysarthria", "Dyscalculia", "Dyschromatopsia", "Dysdiadochokinesis", "Dysesthesia", "Dysgenesis of the cerebellar vermis", "Dysgerminoma", "Dysgraphia", "Dyskinesia", "Dyslexia", "Dysmenorrhea", "Dysmetria", "Dysmetric saccades", "Dysostosis multiplex", "Dyspareunia", "Dysphagia", "Dysphasia", "Dysphonia", "Dysplasia of the femoral head", "Dysplastic corpus callosum", "Dyspnea", "Dystonia", "Dystrophic fingernails", "Dystrophic toenail", "Dysuria", "Ear pain", "Early onset absence seizures", "Early onset of sexual maturation", "Easy fatigability", "Ecchymosis", "Echolalia", "Eclabion", "Eclampsia", "Ectodermal dysplasia", "Ectopia lentis", "Ectopia pupillae", "Ectopic anus", "Ectopic calcification", "Ectopic kidney", "Ectrodactyly", "Ectropion", "Ectropion of lower eyelids", "Eczema", "Eczematoid dermatitis", "Edema of the dorsum of feet", "Edema of the dorsum of hands", "Eeg with abnormally slow frequencies", "Eeg with burst suppression", "Eeg with continuous slow activity", "Eeg with focal epileptiform discharges", "Eeg with focal sharp slow waves", "Eeg with focal sharp waves", "Eeg with focal spike waves", "Eeg with focal spikes", "Eeg with frontal epileptiform discharges", "Eeg with generalized sharp slow waves", "Eeg with generalized slow activity", "Eeg with irregular generalized spike and wave complexes", "Eeg with multifocal slow activity", "Eeg with polyspike wave complexes", "Eeg with spike wave complexes", "Elbow ankylosis", "Elbow flexion contracture", "Elevated alkaline phosphatase of bone origin", "Elevated calcitonin", "Elevated circulating alanine aminotransferase concentration", "Elevated circulating aspartate aminotransferase concentration", "Elevated circulating follicle stimulating hormone level", "Elevated circulating glutaric acid concentration", "Elevated circulating growth hormone concentration", "Elevated circulating long chain fatty acid concentration", "Elevated circulating parathyroid hormone level", "Elevated circulating thyroid stimulating hormone concentration", "Elevated creatine kinase after exercise", "Elevated diastolic blood pressure", "Elevated gamma glutamyltransferase level", "Elevated hemoglobin a1c", "Elevated hepatic transaminase", "Elevated lactate pyruvate ratio", "Elevated mean arterial pressure", "Elevated proportion of cd4 negative cd8 negative alpha beta regulatory t cells", "Elevated pulmonary artery pressure", "Elevated serum acid phosphatase", "Elevated systolic blood pressure", "Elevated tissue non specific alkaline phosphatase", "Elevated total serum tryptase", "Elevated urinary carboxylic acid", "Elevated urinary delta aminolevulinic acid", "Elevated urinary dicarboxylic acid level", "Elevated urinary monocarboxylic acid level", "Elfin facies", "Elliptocytosis", "Elongated superior cerebellar peduncle", "Embryonal neoplasm", "Embryonal renal neoplasm", "Emg abnormality", "Emg axonal abnormality", "Emg chronic denervation signs", "Emg decremental response of compound muscle action potential to repetitive nerve stimulation", "Emg impaired neuromuscular transmission", "Emg myopathic abnormalities", "Emg neuropathic changes", "Emg slow motor conduction", "Emotional lability", "Emphysema", "Enamel hypoplasia", "Encephalocele", "Encephalopathy", "Enchondroma", "Endocardial fibrosis", "Endocarditis", "Enlarged cerebellum", "Enlarged cisterna magna", "Enlarged joints", "Enlarged kidney", "Enlarged metaphyses", "Enlarged ovaries", "Enlarged posterior fossa", "Enlarged thorax", "Enlarged tonsils", "Enlargement of the costochondral junction", "Enlargement of the wrists", "Enterocolitis", "Enthesitis", "Entropion", "Enuresis", "Ependymoma", "Epicanthus", "Epicanthus inversus", "Epidermal acanthosis", "Epidermal hyperkeratosis", "Epidermal nevus", "Epidermoid cyst", "Epigastric pain", "Epileptic encephalopathy", "Epileptic spasm", "Epiphora", "Epiphyseal dysplasia", "Epiphyseal stippling", "Epiretinal membrane", "Episodic ataxia", "Episodic hyperhidrosis", "Episodic hypertension", "Episodic pain", "Episodic tachypnea", "Episodic vomiting", "Epispadias", "Epistaxis", "Equinovarus deformity", "Equinus calcaneus", "Erectile dysfunction", "Erlenmeyer flask deformity of the femurs", "Eruption failure", "Erysipelas", "Erythema", "Erythema nodosum", "Erythematous plaque", "Erythrocyte inclusion bodies", "Erythroderma", "Erythroid hyperplasia", "Erythroid hypoplasia", "Esodeviation", "Esophageal atresia", "Esophageal neoplasm", "Esophageal stenosis", "Esophageal stricture", "Esophageal varix", "Esophagitis", "Ethylmalonic aciduria", "Eunuchoid habitus", "Euryblepharon", "Eversion of lateral third of lower eyelids", "Everted upper lip vermilion", "Exaggerated cupid s bow", "Exaggerated startle response", "Exanthem", "Excessive daytime somnolence", "Excessive salivation", "Excessive wrinkled skin", "Excessive wrinkling of palmar skin", "Exercise induced muscle cramps", "Exercise induced muscle fatigue", "Exercise induced muscle stiffness", "Exercise induced myalgia", "Exercise induced myoglobinuria", "Exercise induced rhabdomyolysis", "Exercise intolerance", "Exertional dyspnea", "Exodeviation", "Exostoses", "Expressive aphasia", "Expressive language delay", "External ear malformation", "External genital hypoplasia", "External ophthalmoplegia", "Extra axial cerebrospinal fluid accumulation", "Extrahepatic cholestasis", "Extramedullary hematopoiesis", "Extrapyramidal dyskinesia", "Extrapyramidal muscular rigidity", "Exudative retinal detachment", "Eyelid coloboma", "Eyelid myoclonus", "Facial asymmetry", "Facial capillary hemangioma", "Facial cleft", "Facial diplegia", "Facial edema", "Facial erythema", "Facial grimacing", "Facial hemangioma", "Facial hyperostosis", "Facial hypertrichosis", "Facial hypotonia", "Facial shape deformation", "Facial telangiectasia", "Failure of eruption of permanent teeth", "Failure to thrive", "Failure to thrive in infancy", "Fair hair", "Falls", "Fasciculations", "Fasting hyperinsulinemia", "Fasting hypoglycemia", "Fat malabsorption", "Fatigable weakness of bulbar muscles", "Fatigable weakness of distal limb muscles", "Fatigable weakness of respiratory muscles", "Fatigable weakness of skeletal muscles", "Fatigable weakness of swallowing muscles", "Fatiguable weakness of proximal limb muscles", "Fatigue", "Fatty replacement of skeletal muscle", "Feeding difficulties", "Feeding difficulties in infancy", "Female external genitalia in individual with 46 xy karyotype", "Female hypogonadism", "Female infertility", "Female reproductive system neoplasm", "Female sexual dysfunction", "Femoral bowing", "Femoral hernia", "Fetal akinesia sequence", "Fetal distress", "Fetal onset", "Fetal polyuria", "Fetal ultrasound soft marker", "Fever", "Fibroadenoma of the breast", "Fibrosarcoma", "Fibrous tissue neoplasm", "Fibular aplasia", "Fibular hypoplasia", "Fine hair", "Finger agnosia", "Finger clinodactyly", "Finger swelling", "Finger syndactyly", "Fingerprint intracellular accumulation of autofluorescent lipopigment storage material", "First degree atrioventricular block", "First dorsal interossei muscle weakness", "Flank pain", "Flared iliac wing", "Flared metaphysis", "Flared nostrils", "Flaring of rib cage", "Flat acetabular roof", "Flat cornea", "Flat face", "Flat forehead", "Flat nasal alae", "Flat occiput", "Flattened epiphysis", "Flattened femoral epiphysis", "Flattened femoral head", "Flexion contracture of digit", "Flexion contracture of thumb", "Fluctuations in consciousness", "Flushing", "Foam cells", "Focal aware seizure", "Focal cortical dysplasia", "Focal cortical dysplasia type ii", "Focal dystonia", "Focal emotional seizure", "Focal impaired awareness seizure", "Focal motor seizure", "Focal myoclonic seizure", "Focal non motor seizure", "Focal onset seizure", "Focal segmental glomerulosclerosis", "Focal t2 hyperintense basal ganglia lesion", "Focal t2 hyperintense brainstem lesion", "Focal tonic seizure", "Focal white matter lesions", "Follicular hyperkeratosis", "Follicular hyperplasia", "Follicular thyroid carcinoma", "Food allergy", "Food intolerance", "Foot acroosteolysis", "Foot dorsiflexor weakness", "Foot oligodactyly", "Fractures of the long bones", "Fragile nails", "Fragile skin", "Fragmented epiphyses", "Freckling", "Frequent falls", "Frontal balding", "Frontal cortical atrophy", "Frontal hirsutism", "Frontal lobe dementia", "Frontotemporal cerebral atrophy", "Frontotemporal dementia", "Full cheeks", "Fulminant hepatic failure", "Functional abnormality of male internal genitalia", "Functional abnormality of the gastrointestinal tract", "Functional abnormality of the inner ear", "Functional abnormality of the middle ear", "Functional intestinal obstruction", "Functional motor deficit", "Furrowed tongue", "Fused cervical vertebrae", "Gait ataxia", "Gait disturbance", "Gait imbalance", "Galactorrhea", "Gangrene", "Gastric ulcer", "Gastritis", "Gastroesophageal reflux", "Gastrointestinal atresia", "Gastrointestinal carcinoma", "Gastrointestinal hemorrhage", "Gastrointestinal infarctions", "Gastrointestinal inflammation", "Gastrointestinal obstruction", "Gastrointestinal stroma tumor", "Gastroparesis", "Gastrostomy tube feeding in infancy", "Gaze evoked horizontal nystagmus", "Gaze evoked nystagmus", "Generalized abnormality of skin", "Generalized aminoaciduria", "Generalized amyotrophy", "Generalized clonic seizure", "Generalized dystonia", "Generalized edema", "Generalized hirsutism", "Generalized hyperkeratosis", "Generalized hyperpigmentation", "Generalized hyperreflexia", "Generalized hypertrichosis", "Generalized hypopigmentation", "Generalized hypopigmentation of hair", "Generalized hypotonia", "Generalized joint laxity", "Generalized limb muscle atrophy", "Generalized lipodystrophy", "Generalized lymphadenopathy", "Generalized muscle weakness", "Generalized myoclonic atonic seizure", "Generalized myoclonic seizure", "Generalized neonatal hypotonia", "Generalized onset motor seizure", "Generalized onset seizure", "Generalized osteoporosis", "Generalized osteosclerosis", "Generalized tonic seizure", "Genetic anticipation", "Genital neoplasm", "Genu valgum", "Genu varum", "Germ cell neoplasia", "Germinoma", "Giant platelets", "Gingival bleeding", "Gingival fibromatosis", "Gingival overgrowth", "Gingival recession", "Gingivitis", "Glaucoma", "Glioblastoma multiforme", "Glioma", "Gliosis", "Global brain atrophy", "Glomerular deposits", "Glomerular sclerosis", "Glomerulonephritis", "Glomerulopathy", "Glomus jugular tumor", "Glossitis", "Glossoptosis", "Glucose intolerance", "Glutaric aciduria", "Glycosuria", "Goiter", "Gonadal dysgenesis", "Gonadal neoplasm", "Gonadoblastoma", "Gonosomal inheritance", "Gout", "Gowers sign", "Grammar specific speech disorder", "Granulocytopenia", "Granulomatosis", "Gray matter heterotopia", "Gynecomastia", "Hallucinations", "Hallux valgus", "Hamartoma", "Hamartoma of the eye", "Hamartoma of tongue", "Hamartomatous polyposis", "Hammertoe", "Hamstring contractures", "Hand apraxia", "Hand clenching", "Hand muscle weakness", "Hand oligodactyly", "Hand polydactyly", "Hand tremor", "Handgrip myotonia", "Happy demeanor", "Hashimoto thyroiditis", "Head banging", "Head titubation", "Head tremor", "Headache", "Heart block", "Heat intolerance", "Heinz bodies", "Hemangioblastoma", "Hemangiomatosis", "Hematological neoplasm", "Hemianopia", "Hemiatrophy", "Hemifacial spasm", "Hemihypertrophy", "Hemimegalencephaly", "Hemiparesis", "Hemiplegia hemiparesis", "Hemivertebrae", "Hemoglobinuria", "Hemolytic anemia", "Hemoptysis", "Hemorrhage of the eye", "Heparan sulfate excretion in urine", "Hepatic cysts", "Hepatic encephalopathy", "Hepatic failure", "Hepatic fibrosis", "Hepatic necrosis", "Hepatitis", "Hepatoblastoma", "Hepatocellular adenoma", "Hepatocellular carcinoma", "Hepatomegaly", "Hepatosplenomegaly", "Hereditary nonpolyposis colorectal carcinoma", "Hernia", "Heterochromia iridis", "Heterogeneous", "Heteronymous hemianopia", "Heterophoria", "Heterotaxy", "Heterotropia", "Hiatus hernia", "High anterior hairline", "High forehead", "High frequency hearing impairment", "High frequency sensorineural hearing impairment", "High hypermetropia", "High myopia", "High narrow palate", "High palate", "High pitched voice", "Highly arched eyebrow", "Hip contracture", "Hip dislocation", "Hip dysplasia", "Hip flexor weakness", "Hip osteoarthritis", "Hip pain", "Hip subluxation", "Hirsutism", "Hoarse cry", "Hoarse voice", "Hodgkin lymphoma", "Holoprosencephaly", "Homocystinuria", "Honeycomb lung", "Horizontal eyebrow", "Horizontal nystagmus", "Horizontal pendular nystagmus", "Horseshoe kidney", "Humeroradial synostosis", "Hydranencephaly", "Hydrocele testis", "Hydrocephalus", "Hydrops fetalis", "Hydroureter", "Hydroxyprolinuria", "Hyperactive deep tendon reflexes", "Hyperactive patellar reflex", "Hyperactivity", "Hyperacusis", "Hyperaldosteronism", "Hyperammonemia", "Hyperautofluorescent retinal lesion", "Hypercalcemia", "Hyperchloremic acidosis", "Hypercholesterolemia", "Hypercoagulability", "Hyperconvex fingernails", "Hyperconvex nail", "Hyperesthesia", "Hyperextensibility at wrists", "Hyperextensibility of the finger joints", "Hyperextensible skin", "Hypergalactosemia", "Hyperglycemia", "Hypergonadotropic hypogonadism", "Hypergranulosis", "Hyperhidrosis", "Hyperhomocystinemia", "Hyperinsulinemic hypoglycemia", "Hyperintensity of cerebral white matter on mri", "Hyperkalemia", "Hyperkeratosis", "Hyperketonemia", "Hyperkinetic movements", "Hyperlipidemia", "Hyperlipoproteinemia", "Hyperlordosis", "Hypermethioninemia", "Hypermetric saccades", "Hypermetropia", "Hypernatriuria", "Hyperorality", "Hyperostosis", "Hyperoxaluria", "Hyperparathyroidism", "Hyperphosphatemia", "Hyperphosphaturia", "Hyperpigmentation in sun exposed areas", "Hyperpigmentation of the skin", "Hyperpituitarism", "Hyperplasia of the maxilla", "Hyperreflexia", "Hyperreflexia in upper limbs", "Hypersomnia", "Hypersplenism", "Hypertelorism", "Hypertension associated with pheochromocytoma", "Hypertensive crisis", "Hyperthyroidism", "Hypertonia", "Hypertrichosis", "Hypertriglyceridemia", "Hypertrophic cardiomyopathy", "Hypertrophic nerve changes", "Hyperuricemia", "Hyperuricosuria", "Hyperventilation", "Hypoamylasemia", "Hypocalcemia", "Hypocalcemic seizures", "Hypocalcemic tetany", "Hypochloremia", "Hypocholesterolemia", "Hypochromia", "Hypochromic anemia", "Hypochromic microcytic anemia", "Hypodontia", "Hypoglycemic coma", "Hypoglycemic seizures", "Hypogonadism", "Hypogonadotropic hypogonadism", "Hypohidrosis", "Hypoinsulinemia", "Hypointensity of cerebral white matter on mri", "Hypokalemia", "Hypokalemic alkalosis", "Hypokalemic metabolic alkalosis", "Hypoketotic hypoglycemia", "Hypokinesia", "Hypolipidemia", "Hypolipoproteinemia", "Hypomelanotic macule", "Hypomethioninemia", "Hypometric saccades", "Hypomimic face", "Hypoparathyroidism", "Hypophosphatemia", "Hypophosphatemic rickets", "Hypopigmentation of the fundus", "Hypopigmentation of the skin", "Hypopigmented macule", "Hypopigmented skin patches", "Hypopituitarism", "Hypoplasia of penis", "Hypoplasia of teeth", "Hypoplasia of the brainstem", "Hypoplasia of the corpus callosum", "Hypoplasia of the ear cartilage", "Hypoplasia of the epiglottis", "Hypoplasia of the femoral head", "Hypoplasia of the fovea", "Hypoplasia of the frontal lobes", "Hypoplasia of the iris", "Hypoplasia of the musculature", "Hypoplasia of the odontoid process", "Hypoplasia of the olfactory bulb", "Hypoplasia of the pons", "Hypoplasia of the radius", "Hypoplasia of the uterus", "Hypoplasia of the vagina", "Hypoplasia of the ventral pons", "Hypoplastic anemia", "Hypoplastic aortic arch", "Hypoplastic cervical vertebrae", "Hypoplastic dermoepidermal hemidesmosomes", "Hypoplastic facial bones", "Hypoplastic female external genitalia", "Hypoplastic fifth fingernail", "Hypoplastic fifth toenail", "Hypoplastic fingernail", "Hypoplastic frontal sinuses", "Hypoplastic heart", "Hypoplastic helices", "Hypoplastic hippocampus", "Hypoplastic ilia", "Hypoplastic iris stroma", "Hypoplastic labia majora", "Hypoplastic labia minora", "Hypoplastic nipples", "Hypoplastic pelvis", "Hypoplastic pubic rami", "Hypoplastic toenails", "Hypoplastic vertebral bodies", "Hypoproteinemia", "Hyporeflexia", "Hyporeflexia of lower limbs", "Hyporeflexia of upper limbs", "Hyposmia", "Hypotelorism", "Hypotension", "Hypothalamic gonadotropin releasing hormone deficiency", "Hypothalamic hamartoma", "Hypothalamic hypothyroidism", "Hypothermia", "Hypotriglyceridemia", "Hypouricemia", "Hypoventilation", "Hypovolemic shock", "Hypsarrhythmia", "Ichthyosis", "Ileus", "Immotile sperm", "Immunodeficiency", "Immunologic hypersensitivity", "Impacted tooth", "Impaired adp induced platelet aggregation", "Impaired antigen specific response", "Impaired collagen induced platelet aggregation", "Impaired distal proprioception", "Impaired distal tactile sensation", "Impaired distal vibration sensation", "Impaired epinephrine induced platelet aggregation", "Impaired glucose tolerance", "Impaired horizontal smooth pursuit", "Impaired mastication", "Impaired neutrophil bactericidal activity", "Impaired oropharyngeal swallow response", "Impaired pain sensation", "Impaired proprioception", "Impaired smooth pursuit", "Impaired social interactions", "Impaired t cell function", "Impaired tactile sensation", "Impaired tandem gait", "Impaired temperature sensation", "Impaired use of nonverbal behaviors", "Impaired vibration sensation at ankles", "Impaired vibration sensation in the lower limbs", "Impaired vibratory sensation", "Impaired visuospatial constructive cognition", "Impairment in personality functioning", "Impairment of activities of daily living", "Impotence", "Inability to walk", "Inappropriate antidiuretic hormone secretion", "Inappropriate behavior", "Inappropriate crying", "Inappropriate laughter", "Incisor macrodontia", "Incomitant strabismus", "Incomplete partition of the cochlea type ii", "Incomplete penetrance", "Incoordination", "Increased adipose tissue", "Increased arm span", "Increased aspartate family amino acid level in urine", "Increased b cell count", "Increased blood pressure", "Increased blood urea nitrogen", "Increased body mass index", "Increased body weight", "Increased bone mineral density", "Increased c peptide level", "Increased cerebral lipofuscin", "Increased circulating acth level", "Increased circulating androgen concentration", "Increased circulating antibody level", "Increased circulating cortisol level", "Increased circulating gonadotropin level", "Increased circulating iga level", "Increased circulating igg level", "Increased circulating igm level", "Increased circulating lactate dehydrogenase concentration", "Increased circulating prolactin concentration", "Increased circulating renin level", "Increased connective tissue", "Increased csf lactate", "Increased density of long bones", "Increased endomysial connective tissue", "Increased fecal porphyrin", "Increased female libido", "Increased head circumference", "Increased hepatic glycogen content", "Increased hepatocellular lipid droplets", "Increased intracranial pressure", "Increased intramyocellular lipid droplets", "Increased laxity of ankles", "Increased ldl cholesterol concentration", "Increased level of hippuric acid in urine", "Increased level of l fucose in urine", "Increased mean corpuscular hemoglobin concentration", "Increased mean corpuscular volume", "Increased megakaryocyte count", "Increased muscle fatiguability", "Increased muscle glycogen content", "Increased muscle lipid content", "Increased nuchal translucency", "Increased overbite", "Increased proportion of cd25 mast cells", "Increased proteinogenic amino acid level in urine", "Increased sensitivity to ionizing radiation", "Increased serine family amino acid in urine", "Increased serum iron", "Increased serum lactate", "Increased serum pyruvate", "Increased serum serotonin", "Increased serum testosterone level", "Increased skull ossification", "Increased sulfur amino acid level in urine", "Increased susceptibility to fractures", "Increased theta frequency activity in eeg", "Increased total bilirubin", "Increased urinary cortisol level", "Increased urinary non proteinogenic amino acid level", "Increased urine alpha ketoglutarate concentration", "Increased urine proteinogenic amino acid derivative level", "Increased vertebral height", "Ineffective esophageal peristalsis", "Infantile axial hypotonia", "Infantile encephalopathy", "Infantile muscular hypotonia", "Infantile onset", "Infantile spasms", "Infection related seizure", "Infectious encephalitis", "Inferior lens subluxation", "Inferior vermis hypoplasia", "Infertility", "Inflammation of the large intestine", "Inflammatory abnormality of the eye", "Inflexible adherence to routines or rituals", "Inguinal hernia", "Insidious onset", "Insomnia", "Inspiratory stridor", "Insulin resistance", "Insulin resistant diabetes mellitus", "Intellectual disability borderline", "Intellectual disability mild", "Intellectual disability moderate", "Intellectual disability profound", "Intellectual disability progressive", "Intellectual disability severe", "Intercostal muscle weakness", "Interictal eeg abnormality", "Intermittent diarrhea", "Internally nucleated skeletal muscle fibers", "Interrupted aortic arch", "Interstitial cardiac fibrosis", "Interstitial pneumonitis", "Intestinal atresia", "Intestinal fistula", "Intestinal hypoplasia", "Intestinal malrotation", "Intestinal polyp", "Intestinal pseudo obstruction", "Intraalveolar phospholipid accumulation", "Intracellular accumulation of autofluorescent lipopigment storage material", "Intracranial hemorrhage", "Intracranial meningioma", "Intractable diarrhea", "Intrauterine growth retardation", "Intrinsic hand muscle atrophy", "Intussusception", "Inverted nipples", "Involuntary movements", "Iridocyclitis", "Iris atrophy", "Iris coloboma", "Iris hypopigmentation", "Iron accumulation in brain", "Iron accumulation in globus pallidus", "Iron deficiency anemia", "Irregular epiphyses", "Irregular femoral epiphysis", "Irregular hyperpigmentation", "Irregular menstruation", "Irregular vertebral endplates", "Irritability", "Ischemic stroke", "J shaped sella turcica", "Jaundice", "Jerky head movements", "Joint contracture of the hand", "Joint contractures involving the joints of the feet", "Joint dislocation", "Joint hemorrhage", "Joint hyperflexibility", "Joint hypermobility", "Joint laxity", "Joint stiffness", "Joint subluxation", "Joint swelling", "Juvenile aseptic necrosis", "Juvenile cataract", "Juvenile myelomonocytic leukemia", "Juvenile onset", "Juvenile rheumatoid arthritis", "Keloids", "Keratitis", "Keratoconjunctivitis", "Keratosis pilaris", "Ketoacidosis", "Ketonuria", "Ketosis", "Ketotic hypoglycemia", "Kinetic tremor", "Knee clonus", "Knee dislocation", "Knee flexion contracture", "Kyphoscoliosis", "Kyphosis", "Labial hypertrophy", "Lack of insight", "Lack of peer relationships", "Lack of skin elasticity", "Lack of t cell function", "Lacrimal duct atresia", "Lacrimal duct stenosis", "Lacrimation abnormality", "Lactic acidosis", "Lacticaciduria", "Lactose intolerance", "Lagopthalmos", "Lambdoidal craniosynostosis", "Language impairment", "Large basal ganglia", "Large beaked nose", "Large earlobe", "Large face", "Large fleshy ears", "Large for gestational age", "Large foramen magnum", "Large forehead", "Large hands", "Large intestinal polyposis", "Large placenta", "Large sella turcica", "Laryngeal cleft", "Laryngeal dystonia", "Laryngeal hypoplasia", "Laryngeal stenosis", "Laryngeal stridor", "Laryngomalacia", "Laryngotracheomalacia", "Late onset", "Lateral clavicle hook", "Left atrial enlargement", "Left to right shunt", "Left ventricular hypertrophy", "Left ventricular noncompaction cardiomyopathy", "Left ventricular outflow tract obstruction", "Left ventricular systolic dysfunction", "Leg muscle stiffness", "Leiomyosarcoma", "Lens subluxation", "Lethal skeletal dysplasia", "Lethargy", "Leukemia", "Leukocytosis", "Leukodystrophy", "Leukoencephalopathy", "Leukonychia", "Leukopenia", "Lewy bodies", "Leydig cell neoplasia", "Lichenification", "Limb ataxia", "Limb dystonia", "Limb fasciculations", "Limb girdle muscle atrophy", "Limb girdle muscle weakness", "Limb girdle muscular dystrophy", "Limb hypertonia", "Limb joint contracture", "Limb muscle weakness", "Limb myoclonus", "Limb pain", "Limb tremor", "Limb undergrowth", "Limitation of joint mobility", "Limitation of knee mobility", "Limitation of movement at ankles", "Limitation of neck motion", "Limited elbow extension", "Limited elbow movement", "Limited extraocular movements", "Limited hip extension", "Limited hip movement", "Limited wrist movement", "Lingual dystonia", "Lipid accumulation in hepatocytes", "Lipoatrophy", "Lipodystrophy", "Lipoma", "Lissencephaly", "Localized hirsutism", "Localized osteoporosis", "Localized skin lesion", "Long clavicles", "Long ear", "Long eyelashes", "Long fingers", "Long foot", "Long hallux", "Long neck", "Long nose", "Long palm", "Long palpebral fissure", "Long penis", "Long philtrum", "Long thorax", "Long toe", "Long tract signs", "Lop ear", "Loss of ability to walk", "Loss of consciousness", "Loss of eyelashes", "Loss of purkinje cells in the cerebellar vermis", "Loss of speech", "Loss of subcutaneous adipose tissue in limbs", "Loss of voice", "Low alkaline phosphatase", "Low anterior hairline", "Low apgar score", "Low back pain", "Low frustration tolerance", "Low grade fever", "Low hanging columella", "Low levels of vitamin d", "Low posterior hairline", "Low set nipples", "Low set posteriorly rotated ears", "Lower extremity joint dislocation", "Lower eyelid coloboma", "Lower limb amyotrophy", "Lower limb asymmetry", "Lower limb hyperreflexia", "Lower limb hypertonia", "Lower limb metaphyseal irregularity", "Lower limb muscle weakness", "Lower limb pain", "Lower limb spasticity", "Lower limb undergrowth", "Lumbar hyperlordosis", "Lumbar kyphosis", "Lumbar scoliosis", "Lung adenocarcinoma", "Lymphangiectasis", "Lymphangioma", "Lymphedema", "Lymphocytosis", "Lymphoma", "Lymphopenia", "Lymphoproliferative disorder", "Macrocephaly at birth", "Macrocytic anemia", "Macrodactyly", "Macrodontia", "Macrodontia of permanent maxillary central incisor", "Macroglossia", "Macrogyria", "Macroorchidism", "Macroscopic hematuria", "Macrotia", "Macrovesicular hepatic steatosis", "Macular atrophy", "Macular coloboma", "Macular degeneration", "Macular hyperpigmentation", "Macular hypoplasia", "Macular purpura", "Macular thickening", "Macule", "Malabsorption", "Malar prominence", "Malar rash", "Male hypogonadism", "Male infertility", "Male pseudohermaphroditism", "Male reproductive system neoplasm", "Male sexual dysfunction", "Malignant genitourinary tract tumor", "Malignant hyperthermia", "Malignant neoplasm of the central nervous system", "Malnutrition", "Malrotation of small bowel", "Mandibular aplasia", "Mandibular prognathia", "Mania", "Mask like facies", "Mastoiditis", "Maternal hypertension", "Maturity onset diabetes of the young", "Meconium stained amniotic fluid", "Medial flaring of the eyebrow", "Median cleft lip", "Median cleft palate", "Mediastinal lymphadenopathy", "Medullary nephrocalcinosis", "Medulloblastoma", "Megalencephaly", "Megaloblastic anemia", "Megalocornea", "Melanocytic nevus", "Melanoma", "Melena", "Membranoproliferative glomerulonephritis", "Memory impairment", "Meningioma", "Meningitis", "Meningocele", "Menorrhagia", "Mental deterioration", "Mesomelia", "Metabolic acidosis", "Metabolic alkalosis", "Metacarpophalangeal joint contracture", "Metamorphopsia", "Metaphyseal chondrodysplasia", "Metaphyseal cupping", "Metaphyseal dysplasia", "Metaphyseal irregularity", "Metaphyseal sclerosis", "Metaphyseal striations", "Metaphyseal widening", "Metatarsal synostosis", "Metatarsus adductus", "Metatarsus valgus", "Methemoglobinemia", "Methylmalonic acidemia", "Methylmalonic aciduria", "Metopic synostosis", "Metrorrhagia", "Microcornea", "Microcytic anemia", "Microdontia", "Microglossia", "Micrographia", "Micromelia", "Micronodular cirrhosis", "Micropenis", "Microphallus", "Microretrognathia", "Microscopic hematuria", "Microtia third degree", "Microvesicular hepatic steatosis", "Middle age onset", "Midface retrusion", "Midline defect of the nose", "Migraine", "Mild global developmental delay", "Mild hearing impairment", "Mild microcephaly", "Mild postnatal growth retardation", "Mild short stature", "Mildly elevated creatine kinase", "Milia", "Minicore myopathy", "Minimal change glomerulonephritis", "Misalignment of incisors", "Missing ribs", "Mitochondrial inheritance", "Mitochondrial myopathy", "Mitochondrial respiratory chain defects", "Mitral stenosis", "Mitral valve calcification", "Mitral valve prolapse", "Mitten deformity", "Mixed demyelinating and axonal polyneuropathy", "Mixed hearing impairment", "Mixed hypo and hyperpigmentation of the skin", "Moderate albuminuria", "Moderate global developmental delay", "Moderate sensorineural hearing impairment", "Moderately reduced visual acuity", "Molar tooth sign on mri", "Molluscoid pseudotumors", "Molluscum contagiosum", "Monochromacy", "Monocytosis", "Monotonic speech", "Mood swings", "Morning glory anomaly", "Morning myoclonic jerks", "Morphological abnormality of the corticospinal tract", "Morphological abnormality of the middle ear", "Morphological abnormality of the pyramidal tract", "Mortality aging", "Motor axonal neuropathy", "Motor delay", "Motor deterioration", "Motor neuron atrophy", "Motor polyneuropathy", "Motor regression", "Motor seizure", "Motor tics", "Mottled pigmentation", "Movement abnormality of the tongue", "Moyamoya phenomenon", "Mucosal telangiectasiae", "Multicystic kidney dysplasia", "Multifactorial inheritance", "Multifocal cerebral white matter abnormalities", "Multifocal epileptiform discharges", "Multifocal seizures", "Multiple cafe au lait spots", "Multiple enchondromatosis", "Multiple gastric polyps", "Multiple impacted teeth", "Multiple joint contractures", "Multiple joint dislocation", "Multiple lentigines", "Multiple lipomas", "Multiple mitochondrial dna deletions", "Multiple myeloma", "Multiple prenatal fractures", "Multiple renal cysts", "Multiple rib fractures", "Multiple rows of eyelashes", "Multiple suture craniosynostosis", "Muscle abnormality related to mitochondrial dysfunction", "Muscle fiber atrophy", "Muscle fiber inclusion bodies", "Muscle fiber necrosis", "Muscle fiber splitting", "Muscle fiber tubular inclusions", "Muscle fibrillation", "Muscle flaccidity", "Muscle hypertrophy of the lower extremities", "Muscle spasm", "Muscle stiffness", "Muscle weakness", "Muscular dystrophy", "Muscular hypotonia of the trunk", "Muscular ventricular septal defect", "Mutism", "Myalgia", "Mydriasis", "Myelodysplasia", "Myelofibrosis", "Myeloid leukemia", "Myelomeningocele", "Myelopathy", "Myeloproliferative disorder", "Myocardial fibrosis", "Myoclonic seizure", "Myoclonic spasms", "Myoclonus", "Myofibrillar myopathy", "Myoglobinuria", "Myopathic facies", "Myopathy", "Myopia", "Myositis", "Myotonia", "Naevus flammeus of the eyelid", "Nail dysplasia", "Nail dystrophy", "Nail pits", "Narrow face", "Narrow foot", "Narrow forehead", "Narrow iliac wing", "Narrow internal auditory canal", "Narrow mouth", "Narrow nasal bridge", "Narrow nasal ridge", "Narrow nose", "Narrow palate", "Narrow palm", "Narrow palpebral fissure", "Narrow pelvis bone", "Narrow vertebral interpedicular distance", "Nasal congestion", "Nasal regurgitation", "Nasal speech", "Nasogastric tube feeding", "Nasogastric tube feeding in infancy", "Nasolacrimal duct obstruction", "Natal tooth", "Nausea", "Nausea and vomiting", "Neck flexor weakness", "Neck muscle weakness", "Negativism", "Nemaline bodies", "Neonatal alloimmune thrombocytopenia", "Neonatal asphyxia", "Neonatal breathing dysregulation", "Neonatal death", "Neonatal hyperbilirubinemia", "Neonatal hypoglycemia", "Neonatal hypotonia", "Neonatal insulin dependent diabetes mellitus", "Neonatal onset", "Neonatal respiratory distress", "Neoplasm", "Neoplasm by histology", "Neoplasm of fatty tissue", "Neoplasm of head and neck", "Neoplasm of striated muscle", "Neoplasm of the adrenal cortex", "Neoplasm of the adrenal gland", "Neoplasm of the breast", "Neoplasm of the colon", "Neoplasm of the ear", "Neoplasm of the endocrine system", "Neoplasm of the eye", "Neoplasm of the gallbladder", "Neoplasm of the gastrointestinal tract", "Neoplasm of the genitourinary tract", "Neoplasm of the heart", "Neoplasm of the inner ear", "Neoplasm of the large intestine", "Neoplasm of the larynx", "Neoplasm of the liver", "Neoplasm of the male external genitalia", "Neoplasm of the nervous system", "Neoplasm of the oral cavity", "Neoplasm of the pancreas", "Neoplasm of the parathyroid gland", "Neoplasm of the peripheral nervous system", "Neoplasm of the pituitary gland", "Neoplasm of the rectum", "Neoplasm of the respiratory system", "Neoplasm of the skeletal system", "Neoplasm of the skin", "Neoplasm of the small intestine", "Neoplasm of the stomach", "Neoplasm of the thyroid gland", "Neoplasm of the tongue", "Neoplasm of the tracheobronchial system", "Nephritis", "Nephrocalcinosis", "Nephrogenic diabetes insipidus", "Nephrolithiasis", "Nephronophthisis", "Nephropathy", "Nephrotic syndrome", "Neuralgia", "Neurodegeneration", "Neuroendocrine neoplasm", "Neurofibrillary tangles", "Neurofibromas", "Neurogenic bladder", "Neuroinflammation", "Neuromuscular dysphagia", "Neuronal loss in basal ganglia", "Neuronal loss in central nervous system", "Neuronal loss in the cerebral cortex", "Neuropathic arthropathy", "Neutropenia in presence of anti neutropil antibodies", "Neutrophilia", "Nevus", "Night sweats", "No social interaction", "Nocturia", "Nocturnal hypoventilation", "Nocturnal seizures", "Nodular goiter", "Non hodgkin lymphoma", "Non medullary thyroid carcinoma", "Non midline cleft lip", "Non midline cleft palate", "Non motor seizure", "Non obstructive azoospermia", "Noncommunicating hydrocephalus", "Noncompaction cardiomyopathy", "Nonimmune hydrops fetalis", "Nonketotic hypoglycemia", "Nonprogressive", "Nonprogressive cerebellar ataxia", "Nonprogressive encephalopathy", "Nonspherocytic hemolytic anemia", "Normochromic anemia", "Normocytic anemia", "Nuclear cataract", "Numerous nevi", "Numerous pigmented freckles", "Nyctalopia", "Nystagmus induced head nodding", "Obsessive compulsive behavior", "Obsessive compulsive trait", "Obstructive sleep apnea", "Occipital cortical atrophy", "Occipital encephalocele", "Occipital meningocele", "Ocular albinism", "Ocular anterior segment dysgenesis", "Ocular pain", "Oculogyric crisis", "Oculomotor apraxia", "Oculomotor nerve palsy", "Oligoarthritis", "Oligodactyly", "Oligodontia", "Oligohydramnios", "Oligomenorrhea", "Oligosacchariduria", "Oligospermia", "Oliguria", "Olivopontocerebellar atrophy", "Olivopontocerebellar hypoplasia", "Omphalocele", "Onion bulb formation", "Onset", "Onychogryposis", "Onychogryposis of toenails", "Onycholysis", "Onychomycosis", "Open angle glaucoma", "Open bite", "Open mouth", "Open operculum", "Ophthalmoparesis", "Opisthotonus", "Opportunistic infection", "Opsoclonus", "Optic atrophy", "Optic disc coloboma", "Optic disc hypoplasia", "Optic disc pallor", "Optic nerve dysplasia", "Optic nerve hypoplasia", "Optic neuropathy", "Oral aversion", "Oral cavity bleeding", "Oral cleft", "Oral leukoplakia", "Oral mucosal blisters", "Oral pharyngeal dysphagia", "Oral ulcer", "Orchitis", "Organic aciduria", "Orofacial dyskinesia", "Oromandibular dystonia", "Oromotor apraxia", "Oroticaciduria", "Orthopnea", "Orthostatic hypotension", "Orthostatic hypotension due to autonomic dysfunction", "Osteoarthritis", "Osteochondroma", "Osteochondrosis", "Osteolysis", "Osteolysis involving bones of the feet", "Osteolysis involving bones of the upper limbs", "Osteolytic defects of the distal phalanges of the hand", "Osteomalacia", "Osteomyelitis", "Osteopenia", "Osteopetrosis", "Osteoporosis", "Osteosarcoma", "Otitis media", "Otosclerosis", "Oval face", "Ovarian carcinoma", "Ovarian cyst", "Ovarian gonadoblastoma", "Ovarian neoplasm", "Ovarian papillary adenocarcinoma", "Overfolding of the superior helices", "Overfriendliness", "Overgrowth", "Overhanging nasal tip", "Overlapping fingers", "Overlapping toe", "Overriding aorta", "Overtubulated long bones", "Overweight", "Ovoid vertebral bodies", "Ovotestis", "Pace of progression", "Pain", "Pain in head and neck region", "Pain insensitivity", "Pallor", "Palmar hyperhidrosis", "Palmar pits", "Palmar telangiectasia", "Palmoplantar blistering", "Palmoplantar cutis laxa", "Palmoplantar hyperhidrosis", "Palpebral edema", "Palpitations", "Pancreatic adenocarcinoma", "Pancreatic cysts", "Pancreatic endocrine tumor", "Pancreatic fibrosis", "Pancreatic hypoplasia", "Pancreatic islet cell hyperplasia", "Pancreatitis", "Pancytopenia", "Panhypogammaglobulinemia", "Panhypopituitarism", "Panniculitis", "Papillary renal cell carcinoma", "Papillary thyroid carcinoma", "Papilledema", "Papilloma", "Papule", "Paracentral scotoma", "Paraganglioma", "Parakeratosis", "Paralysis", "Paranoia", "Paraparesis", "Paraplegia", "Paraplegia paraparesis", "Parasomnia", "Parathyroid adenoma", "Parathyroid carcinoma", "Parathyroid hyperplasia", "Paresthesia", "Parietal bossing", "Parietal cortical atrophy", "Parietal foramina", "Parkinsonism", "Parkinsonism with favorable response to dopaminergic medication", "Paronychia", "Paroxysmal bursts of laughter", "Paroxysmal dystonia", "Paroxysmal involuntary eye movements", "Paroxysmal ventricular tachycardia", "Partial agenesis of the corpus callosum", "Partial albinism", "Partial anomalous pulmonary venous return", "Partial duplication of the phalanx of hand", "Patchy alopecia", "Patchy changes of bone mineral density", "Patchy hypopigmentation of hair", "Patchy palmoplantar hyperkeratosis", "Patellar aplasia", "Patellar dislocation", "Patellar hypoplasia", "Patellar subluxation", "Patent ductus arteriosus", "Patent foramen ovale", "Pathologic fracture", "Pectus carinatum", "Pectus excavatum", "Pectus excavatum of inferior sternum", "Pedal edema", "Pediatric onset", "Pelvic girdle muscle weakness", "Pelvic kidney", "Pendular nystagmus", "Penetrating foot ulcers", "Peptic ulcer", "Perianal abscess", "Periauricular skin pits", "Pericardial effusion", "Pericarditis", "Perifoveal ring of hyperautofluorescence", "Perimembranous ventricular septal defect", "Periodic paralysis", "Periodontitis", "Periorbital edema", "Periorbital fullness", "Peripheral arterial stenosis", "Peripheral axonal degeneration", "Peripheral axonal neuropathy", "Peripheral cyanosis", "Peripheral demyelination", "Peripheral edema", "Peripheral hypermyelination", "Peripheral hypomyelination", "Peripheral neuropathy", "Peripheral opacification of the cornea", "Peripheral pulmonary artery stenosis", "Peripheral retinal avascularization", "Peripheral visual field loss", "Periportal fibrosis", "Perisylvian polymicrogyria", "Peritoneal abscess", "Peritonitis", "Periventricular cysts", "Periventricular heterotopia", "Periventricular leukomalacia", "Periventricular nodular heterotopia", "Periventricular white matter hyperintensities", "Peroneal muscle atrophy", "Perseveration", "Persistence of hemoglobin f", "Persistence of primary teeth", "Persistent ebv viremia", "Persistent head lag", "Personality changes", "Pes cavus", "Pes planus", "Pes valgus", "Petechiae", "Peters anomaly", "Pharyngitis", "Phenotypic variability", "Pheochromocytoma", "Phimosis", "Phocomelia", "Phonophobia", "Photophobia", "Photopsia", "Photoreceptor layer loss on macular oct", "Phthisis bulbi", "Physical urticaria", "Pierre robin sequence", "Pigmentary retinopathy", "Pili canaliculi", "Pili torti", "Pilomatrixoma", "Pineal cyst", "Pituitary adenoma", "Pituitary growth hormone cell adenoma", "Pituitary hypothyroidism", "Pituitary prolactin cell adenoma", "Plagiocephaly", "Plantar hyperkeratosis", "Platybasia", "Platyspondyly", "Pleural effusion", "Pleuritis", "Pneumonia", "Pneumothorax", "Poikilocytosis", "Poikiloderma", "Pointed chin", "Polar cataract", "Pollakisuria", "Polyarticular arthropathy", "Polycystic kidney dysplasia", "Polycystic liver disease", "Polycythemia", "Polydactyly", "Polygenic inheritance", "Polyhydramnios", "Polymicrogyria", "Polyneuropathy", "Polyphagia", "Polysplenia", "Polyuria", "Pontocerebellar atrophy", "Poor appetite", "Poor coordination", "Poor eye contact", "Poor fine motor coordination", "Poor gross motor coordination", "Poor head control", "Poor motor coordination", "Poor speech", "Poor suck", "Poor wound healing", "Porencephalic cyst", "Porokeratosis", "Porphyrinuria", "Portal fibrosis", "Portal vein thrombosis", "Positional foot deformity", "Positive romberg sign", "Post partum hemorrhage", "Postaxial foot polydactyly", "Postaxial hand polydactyly", "Postaxial polydactyly", "Posterior blepharitis", "Posterior embryotoxon", "Posterior fossa cyst", "Posterior pharyngeal cleft", "Posterior pituitary dysgenesis", "Posterior polar cataract", "Posterior subcapsular cataract", "Posteriorly rotated ears", "Postexertional malaise", "Postnatal growth retardation", "Postural instability", "Postural tremor", "Potter facies", "Preauricular skin tag", "Preaxial foot polydactyly", "Preaxial hand polydactyly", "Preaxial polydactyly", "Precocious atherosclerosis", "Predominantly lower limb lymphedema", "Prelingual sensorineural hearing impairment", "Premature adrenarche", "Premature arteriosclerosis", "Premature birth", "Premature coronary artery atherosclerosis", "Premature graying of hair", "Premature loss of primary teeth", "Premature loss of teeth", "Premature osteoarthritis", "Premature ovarian insufficiency", "Premature pubarche", "Premature rupture of membranes", "Premature skin wrinkling", "Premature thelarche", "Premature ventricular contraction", "Prematurely aged appearance", "Prenatal maternal abnormality", "Prenatal movement abnormality", "Primary adrenal insufficiency", "Primary amenorrhea", "Primary congenital glaucoma", "Primary gonadal insufficiency", "Primary hypercortisolism", "Primary hyperparathyroidism", "Primary microcephaly", "Primary peritoneal carcinoma", "Primitive neuroectodermal tumor", "Primitive reflex", "Productive cough", "Profound global developmental delay", "Profound hearing impairment", "Profound sensorineural hearing impairment", "Progeroid facial appearance", "Progressive", "Progressive cerebellar ataxia", "Progressive distal muscle weakness", "Progressive encephalopathy", "Progressive external ophthalmoplegia", "Progressive extrapyramidal movement disorder", "Progressive flexion contractures", "Progressive gait ataxia", "Progressive hearing impairment", "Progressive inability to walk", "Progressive leukoencephalopathy", "Progressive macrocephaly", "Progressive microcephaly", "Progressive muscle weakness", "Progressive neurologic deterioration", "Progressive night blindness", "Progressive peripheral neuropathy", "Progressive pes cavus", "Progressive proximal muscle weakness", "Progressive psychomotor deterioration", "Progressive pulmonary function impairment", "Progressive sensorineural hearing impairment", "Progressive spastic paraparesis", "Progressive spastic paraplegia", "Progressive spastic quadriplegia", "Progressive spasticity", "Progressive visual field defects", "Progressive visual loss", "Prolonged bleeding after dental extraction", "Prolonged bleeding after surgery", "Prolonged bleeding following circumcision", "Prolonged bleeding following procedure", "Prolonged bleeding time", "Prolonged neonatal jaundice", "Prolonged partial thromboplastin time", "Prolonged qtc interval", "Prominent antihelix", "Prominent antitragus", "Prominent digit pad", "Prominent ear helix", "Prominent eyelashes", "Prominent forehead", "Prominent metopic ridge", "Prominent nasal bridge", "Prominent nasal tip", "Prominent nasolabial fold", "Prominent nose", "Prominent occiput", "Prominent sternum", "Prominent superficial blood vessels", "Prominent supraorbital ridges", "Prominent umbilicus", "Prominent veins on trunk", "Proportionate short stature", "Proportionate tall stature", "Proptosis", "Prostate neoplasm", "Protein avoidance", "Protein losing enteropathy", "Protruding ear", "Protruding tongue", "Protrusio acetabuli", "Protuberant abdomen", "Proximal amyotrophy", "Proximal femoral epiphysiolysis", "Proximal femoral metaphyseal abnormality", "Proximal femoral metaphyseal irregularity", "Proximal muscle weakness", "Proximal muscle weakness in lower limbs", "Proximal muscle weakness in upper limbs", "Proximal renal tubular acidosis", "Proximal symphalangism", "Proximal tubulopathy", "Proximal upper limb amyotrophy", "Pruritus", "Pseudoarthrosis", "Pseudobulbar paralysis", "Pseudobulbar signs", "Pseudoepiphyses", "Pseudoepiphyses of hand bones", "Pseudoepiphyses of the metacarpals", "Pseudohypoaldosteronism", "Pseudohypoparathyroidism", "Psoriasiform dermatitis", "Psychogenic non epileptic seizure", "Psychomotor deterioration", "Psychomotor retardation", "Psychosis", "Psychotic episodes", "Psychotic mentation", "Pterygium", "Ptosis", "Puberty and gonadal disorders", "Pulmonary artery atresia", "Pulmonary artery dilatation", "Pulmonary artery hypoplasia", "Pulmonary artery stenosis", "Pulmonary carcinoid tumor", "Pulmonary cyst", "Pulmonary edema", "Pulmonary embolism", "Pulmonary fibrosis", "Pulmonary hemorrhage", "Pulmonary hypoplasia", "Pulmonary infiltrates", "Pulmonary insufficiency", "Pulmonary interstitial high resolution computed tomography abnormality", "Pulmonary venous hypertension", "Pulmonic stenosis", "Pulverulent cataract", "Punctate cataract", "Pure red cell aplasia", "Purpura", "Pustule", "Pyelonephritis", "Pyoderma gangrenosum", "Pyridoxine responsive sideroblastic anemia", "Quadriceps muscle weakness", "Radial bowing", "Radial deviation of the 2nd finger", "Radial deviation of the hand", "Radial deviation of the hand or of fingers of the hand", "Radioulnar dislocation", "Radioulnar synostosis", "Ragged red muscle fibers", "Rapidly progressive", "Raynaud phenomenon", "Reactive hypoglycemia", "Receptive language delay", "Rectal fistula", "Rectal prolapse", "Recurrent", "Recurrent abscess formation", "Recurrent acute respiratory tract infection", "Recurrent aspiration pneumonia", "Recurrent bacterial infections", "Recurrent bacterial skin infections", "Recurrent bronchitis", "Recurrent bronchopulmonary infections", "Recurrent corneal erosions", "Recurrent ear infections", "Recurrent fever", "Recurrent fractures", "Recurrent gastroenteritis", "Recurrent hand flapping", "Recurrent herpes", "Recurrent hypoglycemia", "Recurrent infection of the gastrointestinal tract", "Recurrent joint dislocation", "Recurrent lower respiratory tract infections", "Recurrent mycobacterial infections", "Recurrent opportunistic infections", "Recurrent otitis media", "Recurrent pancreatitis", "Recurrent paroxysmal headache", "Recurrent pharyngitis", "Recurrent pneumonia", "Recurrent respiratory infections", "Recurrent sinopulmonary infections", "Recurrent sinusitis", "Recurrent skin infections", "Recurrent staphylococcal infections", "Recurrent staphylococcus aureus infections", "Recurrent tonsillitis", "Recurrent upper and lower respiratory tract infections", "Recurrent urinary tract infections", "Recurrent viral infections", "Red eye", "Red green dyschromatopsia", "Red hair", "Reduced antigen specific t cell proliferation", "Reduced antithrombin iii activity", "Reduced brain n acetyl aspartate level by mrs", "Reduced c peptide level", "Reduced circulating prolactin concentration", "Reduced consciousness confusion", "Reduced delayed hypersensitivity", "Reduced factor viii activity", "Reduced factor xi activity", "Reduced factor xii activity", "Reduced factor xiii activity", "Reduced forced expiratory volume in one second", "Reduced forced vital capacity", "Reduced natural killer cell count", "Reduced pancreatic beta cells", "Reduced protein c activity", "Reduced protein s activity", "Reduced renal corticomedullary differentiation", "Reduced sperm motility", "Reduced subcutaneous adipose tissue", "Reduced systolic function", "Reduced tendon reflexes", "Reduced visual acuity", "Reduced vital capacity", "Reduction of neutrophil motility", "Redundant neck skin", "Redundant skin", "Refractory anemia", "Regional abnormality of skin", "Relative macrocephaly", "Renal agenesis", "Renal angiomyolipoma", "Renal cell carcinoma", "Renal cortical cysts", "Renal cortical microcysts", "Renal cyst", "Renal duplication", "Renal dysplasia", "Renal fanconi syndrome", "Renal fibrosis", "Renal hamartoma", "Renal hypoplasia", "Renal hypoplasia aplasia", "Renal insufficiency", "Renal magnesium wasting", "Renal malrotation", "Renal phosphate wasting", "Renal potassium wasting", "Renal salt wasting", "Renal tubular acidosis", "Renal tubular atrophy", "Renal tubular dysfunction", "Renal tubular epithelial necrosis", "Renovascular hypertension", "Repetitive compulsive behavior", "Respiratory alkalosis", "Respiratory arrest", "Respiratory distress", "Respiratory failure", "Respiratory failure requiring assisted ventilation", "Respiratory insufficiency", "Respiratory insufficiency due to defective ciliary clearance", "Respiratory paralysis", "Respiratory tract infection", "Response to drugs acting on neuromuscular transmission", "Resting tremor", "Restless legs", "Restlessness", "Restrictive behavior", "Restrictive cardiomyopathy", "Restrictive ventilatory defect", "Reticulated skin pigmentation", "Reticulocytopenia", "Reticulocytosis", "Retinal arteriolar tortuosity", "Retinal atrophy", "Retinal coloboma", "Retinal degeneration", "Retinal detachment", "Retinal dysplasia", "Retinal dystrophy", "Retinal fold", "Retinal hamartoma", "Retinal hemorrhage", "Retinal neovascularization", "Retinal perforation", "Retinal pigment epithelial atrophy", "Retinal pigment epithelial mottling", "Retinal telangiectasia", "Retinal thinning", "Retinal vascular tortuosity", "Retinopathy", "Retrocollis", "Retrognathia", "Rhabdomyolysis", "Rhabdomyosarcoma", "Rhegmatogenous retinal detachment", "Rheumatoid arthritis", "Rheumatoid factor positive", "Rhinitis", "Rhizomelia", "Rib fusion", "Rib segmentation abnormalities", "Rickets", "Ridged nail", "Rieger anomaly", "Right aortic arch with mirror image branching", "Right bundle branch block", "Right ventricular cardiomyopathy", "Right ventricular dilatation", "Right ventricular hypertrophy", "Rigidity", "Rimmed vacuoles", "Rod cone dystrophy", "Rotary nystagmus", "Round ear", "Round face", "Saccadic oscillation", "Saccadic smooth pursuit", "Sagittal craniosynostosis", "Sandal gap", "Sarcoma", "Scaling skin", "Scanning speech", "Scaphocephaly", "Scapular winging", "Scarring", "Scarring alopecia of scalp", "Schistocytosis", "Schizencephaly", "Schizophrenia", "Schwannoma", "Scleral staphyloma", "Sclerocornea", "Scleroderma", "Sclerosis of hand bone", "Sclerosis of skull base", "Scotoma", "Scrotal hypoplasia", "Sea blue histiocytosis", "Seborrheic dermatitis", "Second degree atrioventricular block", "Secondary amenorrhea", "Secondary growth hormone deficiency", "Secondary microcephaly", "Secretory diarrhea", "Secundum atrial septal defect", "Segmental peripheral demyelination remyelination", "Selective tooth agenesis", "Self injurious behavior", "Self mutilation", "Semilobar holoprosencephaly", "Senile plaques", "Sensorimotor neuropathy", "Sensory ataxia", "Sensory axonal neuropathy", "Sensory neuropathy", "Sepsis", "Septate vagina", "Septic arthritis", "Septo optic dysplasia", "Serositis", "Severe combined immunodeficiency", "Severe cytomegalovirus infection", "Severe demyelination of the white matter", "Severe expressive language delay", "Severe failure to thrive", "Severe global developmental delay", "Severe hearing impairment", "Severe infection", "Severe intrauterine growth retardation", "Severe lactic acidosis", "Severe muscular hypotonia", "Severe photosensitivity", "Severe postnatal growth retardation", "Severe short limb dwarfism", "Severe short stature", "Severe varicella zoster infection", "Severe viral infection", "Severely reduced visual acuity", "Shagreen patch", "Shallow anterior chamber", "Shallow orbits", "Shawl scrotum", "Shield chest", "Shock", "Short 1st metacarpal", "Short attention span", "Short chin", "Short clavicles", "Short digit", "Short face", "Short femur", "Short foot", "Short fourth metatarsal", "Short lingual frenulum", "Short long bone", "Short lower limbs", "Short middle phalanx of finger", "Short nail", "Short nose", "Short palm", "Short palpebral fissure", "Short phalanx of the thumb", "Short philtrum", "Short proximal phalanx of finger", "Short ribs", "Short stepped shuffling gait", "Short sternum", "Short thorax", "Short thumb", "Short tibia", "Short umbilical cord", "Short upper lip", "Shortened pr interval", "Shortened qt interval", "Shortening of all distal phalanges of the fingers", "Shortening of all middle phalanges of the fingers", "Shoulder dislocation", "Shoulder girdle muscle atrophy", "Shoulder girdle muscle weakness", "Shoulder pain", "Shuffling gait", "Shyness", "Sideroblastic anemia", "Simple ear", "Simple febrile seizure", "Simplified gyral pattern", "Single fiber emg abnormality", "Single naris", "Single transverse palmar crease", "Single ventricle", "Sinus bradycardia", "Sinus tachycardia", "Sirenomelia", "Skeletal dysplasia", "Skeletal muscle atrophy", "Skeletal muscle hypertrophy", "Skeletal myopathy", "Skin appendage neoplasm", "Skin dimple", "Skin erosion", "Skin nodule", "Skin picking", "Skin pit", "Skin plaque", "Skin rash", "Skin tags", "Skin ulcer", "Skin vesicle", "Skull asymmetry", "Slanting of the palpebral fissure", "Sleep apnea", "Sleep disturbance", "Sleep wake cycle disturbance", "Slender build", "Slender finger", "Slender long bone", "Sloping forehead", "Slow decrease in visual acuity", "Slow pupillary light response", "Slow saccadic eye movements", "Slowly progressive", "Slurred speech", "Small anterior fontanelle", "Small basal ganglia", "Small cerebral cortex", "Small earlobe", "Small epiphyses", "Small face", "Small for gestational age", "Small hand", "Small intestinal dysmotility", "Small nail", "Small placenta", "Smooth muscle antibody positivity", "Smooth philtrum", "Snoring", "Social and occupational deterioration", "Soft doughy skin", "Soft skin", "Soft tissue sarcoma", "Solitary median maxillary central incisor", "Somatic mosaicism", "Somatic mutation", "Somatic sensory dysfunction", "Sound sensitivity", "Sparse and thin eyebrow", "Sparse body hair", "Sparse eyebrow", "Sparse eyelashes", "Sparse hair", "Sparse lateral eyebrow", "Sparse or absent eyelashes", "Sparse scalp hair", "Spastic ataxia", "Spastic diplegia", "Spastic dysarthria", "Spastic gait", "Spastic hyperactive bladder", "Spastic paraparesis", "Spastic paraparetic gait", "Spastic paraplegia", "Spastic tetraparesis", "Spastic tetraplegia", "Spasticity", "Specific learning disability", "Speech apraxia", "Speech articulation difficulties", "Spina bifida", "Spina bifida occulta", "Spinal canal stenosis", "Spinal cord compression", "Spinal cord lesion", "Spinal cord tumor", "Spinal muscular atrophy", "Spinal rigidity", "Splanchnic vein thrombosis", "Splenomegaly", "Split nail", "Spoken word recognition deficit", "Spondyloepimetaphyseal dysplasia", "Spondyloepiphyseal dysplasia", "Spondylolisthesis", "Spondylolysis", "Spontaneous abortion", "Spontaneous hemolytic crises", "Spontaneous pain sensation", "Spontaneous recurrent epistaxis", "Sporadic", "Spotty hyperpigmentation", "Spotty hypopigmentation", "Sprengel anomaly", "Squamous cell carcinoma", "Squamous cell carcinoma of the skin", "Square face", "Squared iliac bones", "Stage 5 chronic kidney disease", "Staring gaze", "Status epilepticus", "Status epilepticus with prominent motor symptoms", "Stenosis of the external auditory canal", "Steppage gait", "Stereotypical hand wringing", "Stereotypy", "Steroid resistant nephrotic syndrome", "Stiff skin", "Stillbirth", "Stomach cancer", "Stomatitis", "Stomatocytosis", "Stooped posture", "Streak ovary", "Striae distensae", "Stridor", "Stroke", "Stroke like episode", "Stuttering", "Subacute progressive viral hepatitis", "Subarachnoid hemorrhage", "Subcapsular cataract", "Subcortical band heterotopia", "Subcortical cerebral atrophy", "Subcortical heterotopia", "Subcutaneous hemorrhage", "Subcutaneous nodule", "Subdural hemorrhage", "Subependymal cysts", "Subglottic stenosis", "Submucous cleft of soft and hard palate", "Submucous cleft soft palate", "Subretinal fluid", "Subsarcolemmal accumulations of abnormally shaped mitochondria", "Substantia nigra gliosis", "Subvalvular aortic stenosis", "Sudden death", "Sudden episodic apnea", "Sudden loss of visual acuity", "Suicidal ideation", "Sunken cheeks", "Supernumerary bones of the axial skeleton", "Supernumerary nipple", "Supernumerary spleens", "Supernumerary tooth", "Supranuclear gaze palsy", "Supranuclear ophthalmoplegia", "Supravalvular aortic stenosis", "Supraventricular arrhythmia", "Supraventricular tachycardia", "Symphalangism affecting the phalanges of the hand", "Symphalangism of middle phalanx of finger", "Symptomatic seizures", "Syncope", "Syndactyly", "Synostosis involving bones of the hand", "Synostosis involving bones of the lower limbs", "Synostosis involving bones of the upper limbs", "Synostosis involving digits", "Synostosis of carpal bones", "Synostosis of carpals tarsals", "Synostosis of joints", "Synostosis of metacarpals metatarsals", "Synovitis", "Syringomyelia", "Systemic lupus erythematosus", "T cell lymphoma", "T lymphocytopenia", "Tachycardia", "Tachypnea", "Talipes calcaneovalgus", "Talipes equinovalgus", "Talipes equinovarus", "Talipes valgus", "Tall stature", "Tapered distal phalanges of finger", "Tapered finger", "Tarsal synostosis", "Telangiectasia", "Telangiectasia of the skin", "Telecanthus", "Temperature instability", "Temporal cortical atrophy", "Temporal optic disc pallor", "Temporal pattern", "Tented upper lip vermilion", "Teratoma", "Testicular adrenal rest tumor", "Testicular atrophy", "Testicular dysgenesis", "Tetany", "Tetralogy of fallot", "Tetraparesis", "Tetraplegia", "Tetraplegia tetraparesis", "Thenar muscle atrophy", "Thick cerebral cortex", "Thick corpus callosum", "Thick eyebrow", "Thick hair", "Thick lower lip vermilion", "Thick nasal alae", "Thick upper lip vermilion", "Thick vermilion border", "Thickened calvaria", "Thickened cortex of long bones", "Thickened ears", "Thickened helices", "Thickened nuchal skin fold", "Thickened ribs", "Thickened skin", "Thin bony cortex", "Thin clavicles", "Thin eyebrow", "Thin lower lip vermilion", "Thin nail", "Thin ribs", "Thin skin", "Thin upper lip vermilion", "Thin vermilion border", "Thinning of descemet membrane", "Third degree atrioventricular block", "Thoracic aortic aneurysm", "Thoracic hypoplasia", "Thoracic kyphoscoliosis", "Thoracic kyphosis", "Thoracic scoliosis", "Thoracolumbar kyphoscoliosis", "Thoracolumbar kyphosis", "Thoracolumbar scoliosis", "Thrombocytosis", "Thromboembolism", "Thyroid adenoma", "Thyroid carcinoma", "Thyroiditis", "Tibial bowing", "Tibial torsion", "Tics", "Tiger tail banding", "Tinnitus", "Tip toe gait", "Tissue ischemia", "Titubation", "Toe clinodactyly", "Toe syndactyly", "Toe walking", "Toenail dysplasia", "Tongue atrophy", "Tongue fasciculations", "Tongue nodules", "Tongue thrusting", "Tonic seizure", "Tooth malposition", "Torsion dystonia", "Total anomalous pulmonary venous return", "Toxemia of pregnancy", "Tracheal stenosis", "Tracheobronchomalacia", "Tracheoesophageal fistula", "Tracheomalacia", "Tractional retinal detachment", "Transient global amnesia", "Transient ischemic attack", "Transient neonatal diabetes mellitus", "Transient neutropenia", "Transposition of the great arteries", "Tremor", "Tremor by anatomical site", "Triangular face", "Triangular mouth", "Triangular shaped phalanges of the hand", "Triceps weakness", "Trichorrhexis nodosa", "Tricuspid atresia", "Tricuspid stenosis", "Tricuspid valve prolapse", "Trigonocephaly", "Triphalangeal thumb", "Trismus", "Tritanomaly", "Trophic changes related to pain", "Truncal ataxia", "Truncal obesity", "Truncal titubation", "Truncus arteriosus", "Tube feeding", "Tubulointerstitial nephritis", "Turricephaly", "Type 1 fibers relatively smaller than type 2 fibers", "Type 1 muscle fiber atrophy", "Type 2 muscle fiber atrophy", "Type 2 muscle fiber predominance", "Type i diabetes mellitus", "Type i transferrin isoform profile", "Type ii diabetes mellitus", "Type ii lissencephaly", "Type ii transferrin isoform profile", "Typical absence seizure", "U shaped upper lip vermilion", "Ulnar bowing", "Ulnar claw", "Ulnar deviation of finger", "Ulnar deviation of the 2nd finger", "Ulnar deviation of the hand", "Ulnar deviation of the hand or of fingers of the hand", "Ulnar deviation of the wrist", "Uncombable hair", "Unconjugated hyperbilirubinemia", "Underdeveloped nasal alae", "Underdeveloped supraorbital ridges", "Underdeveloped tragus", "Undetectable electroretinogram", "Undetectable light and dark adapted electroretinogram", "Undetectable visual evoked potentials", "Unexplained fevers", "Unilateral primary pulmonary dysgenesis", "Unilateral ptosis", "Unilateral renal agenesis", "Unsteady gait", "Unusual fungal infection", "Unusual infection", "Unusual infection by anatomical site", "Unusual skin infection", "Upgaze palsy", "Uplifted earlobe", "Upper airway obstruction", "Upper extremity joint dislocation", "Upper eyelid coloboma", "Upper limb amyotrophy", "Upper limb asymmetry", "Upper limb hypertonia", "Upper limb muscle weakness", "Upper limb pain", "Upper limb postural tremor", "Upper limb spasticity", "Upper limb undergrowth", "Upper motor neuron dysfunction", "Upslanted palpebral fissure", "Ureteral duplication", "Ureteral obstruction", "Ureteral stenosis", "Ureterocele", "Ureteropelvic junction obstruction", "Urethral obstruction", "Urethral stenosis", "Urethral stricture", "Urethral valve", "Uric acid nephrolithiasis", "Urinary bladder sphincter dysfunction", "Urinary glycosaminoglycan excretion", "Urinary incontinence", "Urinary retention", "Urinary tract neoplasm", "Urinary urgency", "Urogenital fistula", "Urogenital sinus anomaly", "Urticaria", "Uterine prolapse", "Uveal melanoma", "Uveitis", "Vacuolated lymphocytes", "Vaginal atresia", "Vaginal fistula", "Vaginal neoplasm", "Variable expressivity", "Varicose veins", "Vascular calcification", "Vascular dilatation", "Vascular neoplasm", "Vascular skin abnormality", "Vascular tortuosity", "Vasculitis", "Vegetative state", "Vein of galen aneurysmal malformation", "Velopharyngeal insufficiency", "Venous insufficiency", "Venous malformation", "Venous thrombosis", "Ventilator dependence with inability to wean", "Ventricular arrhythmia", "Ventricular escape rhythm", "Ventricular fibrillation", "Ventricular hypertrophy", "Ventricular preexcitation", "Ventricular septal hypertrophy", "Ventricular tachycardia", "Ventriculomegaly", "Verrucae", "Vertebral arch anomaly", "Vertebral clefting", "Vertebral compression fracture", "Vertebral fusion", "Vertebral hypoplasia", "Vertebral segmentation defect", "Vertebral wedging", "Vertical nystagmus", "Vertical supranuclear gaze palsy", "Vertigo", "Very long chain fatty acid accumulation", "Vestibular dysfunction", "Viral encephalitis", "Viral hepatitis", "Viral infection induced rhabdomyolysis", "Visceral angiomatosis", "Visual acuity test abnormality", "Visual field defect", "Visual fixation instability", "Visual hallucinations", "Visual impairment", "Visual loss", "Vitamin b12 deficiency", "Vitiligo", "Vitreoretinopathy", "Vitreous floaters", "Vitreous hemorrhage", "Vitritis", "Vocal cord paralysis", "Vocal cord paresis", "Volvulus", "Vomiting", "Waddling gait", "Weak cry", "Weak voice", "Weakness due to upper motor neuron dysfunction", "Weakness of facial musculature", "Weakness of long finger extensor muscles", "Weakness of muscles of respiration", "Weakness of the intrinsic hand muscles", "Webbed neck", "Weight loss", "Wheezing", "White forelock", "White hair", "Wide anterior fontanel", "Wide cranial sutures", "Wide intermamillary distance", "Wide mouth", "Wide nasal bridge", "Wide nasal ridge", "Wide nose", "Widely patent fontanelles and sutures", "Widely spaced incisors", "Widely spaced teeth", "Widened cerebral subarachnoid space", "Widened subarachnoid space", "Widow s peak", "Woolly hair", "Wormian bones", "Wrist flexion contracture", "Writer s cramp", "X linked dominant inheritance", "X linked recessive inheritance", "Xanthomatosis", "Xerostomia", "Yellow white lesions of the retina", "Young adult onset", "Zonular cataract"], "available_proteins": ["AAAS", "AARS", "AARS2", "AASS", "ABCB1", "ABCB7", "ABCD3", "ABHD12", "ACACA", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACO2", "ACOX1", "ACP2", "ACSF3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ADAM17", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADPRHL2", "ADSL", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKT2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ANAPC1", "ANK3", "ANKLE2", "ANKRD17", "ANLN", "ANXA11", "AP1B1", "AP2M1", "AP3B1", "AP3D1", "APOL2", "APP", "APRT", "ARCN1", "ARHGDIA", "ARHGEF2", "ARID1A", "ARL2", "ARL3", "ARL6IP1", "ARPC1B", "ASAH1", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD3A", "ATIC", "ATP1A1", "ATP2A2", "ATP2B4", "ATP5A1", "ATP6AP1", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATXN10", "B4GAT1", "BANF1", "BAZ1B", "BCAP31", "BCAT2", "BLM", "BLVRA", "BMS1", "BPTF", "BRCA1", "BUB1B", "BUB3", "BUD23", "C19orf70", "C1QBP", "CAD", "CALD1", "CALR", "CAMK2G", "CAPN1", "CARS", "CAST", "CCDC47", "CCT5", "CD2AP", "CD3EAP", "CDC42", "CDC73", "CDK4", "CDK5", "CDK6", "CFL2", "CHAMP1", "CHD4", "CHORDC1", "CHST14", "CISD2", "CIZ1", "CLASP1", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNNM4", "CNOT1", "CNOT3", "CNP", "COA3", "COA7", "COG7", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COX2", "COX4I1", "COX5A", "CPNE1", "CPOX", "CPSF1", "CPT2", "CRKL", "CRTAP", "CSNK2B", "CSTB", "CTBP1", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTSA", "CUL3", "CUL4B", "CWF19L1", "CYB5R3", "CYC1", "DARS", "DARS2", "DCPS", "DCTN1", "DCTN4", "DCXR", "DDB1", "DDOST", "DDRGK1", "DDX3X", "DDX41", "DDX6", "DGCR8", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHX16", "DHX30", "DHX37", "DHX38", "DIABLO", "DIAPH1", "DIAPH3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPF2", "DPM1", "DPP9", "DSG2", "DSP", "DST", "DYNC1H1", "DYNC1I2", "DYNLL1", "ECE1", "ECHS1", "EDC3", "EEF1A2", "EEF2", "EFL1", "EFTUD2", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF3F", "EIF4A3", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELP1", "ELP2", "EMC1", "EMD", "EMG1", "EPB41", "EPRS", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERLIN2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXOC2", "EXOC7", "EXOSC1", "EXOSC3", "EZR", "FAH", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FDFT1", "FDPS", "FECH", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FOXC1", "FRG1", "FSCN1", "FTO", "FUS", "FXR1", "G6PD", "GAA", "GALK1", "GALNT2", "GANAB", "GAPVD1", "GARS", "GATB", "GBA", "GCDH", "GDI1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGCX", "GIGYF2", "GINS1", "GLA", "GLB1", "GLDC", "GLE1", "GLMN", "GLRX5", "GLS", "GLUD1", "GM2A", "GMPPA", "GNAI2", "GNAI3", "GNPAT", "GNS", "GOT2", "GPAA1", "GPD2", "GPI", "GPRASP2", "GRHPR", "GSR", "GSS", "GSTM3", "GTF2I", "GTPBP3", "GUSB", "GYS1", "H2AFY", "HADH", "HADHA", "HADHB", "HAX1", "HCCS", "HCFC1", "HELLS", "HERC2", "HEXA", "HEXB", "HIBCH", "HIST1H1E", "HK1", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HMGA1", "HMGB3", "HMGCL", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HPRT1", "HPS6", "HSD17B10", "HSD17B4", "HSPA9", "HSPB1", "HSPD1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFT27", "IGBP1", "IGF2R", "INF2", "IRS4", "ITCH", "ITPA", "IVD", "JUP", "KARS", "KDM1A", "KDM3B", "KDSR", "KEAP1", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF4A", "KIFBP", "KLC2", "KMT2A", "L2HGDH", "LAMTOR2", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LEMD3", "LETM1", "LIPA", "LLGL1", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LONP1", "LRBA", "LRPAP1", "LRPPRC", "LSS", "MACF1", "MAGED2", "MAGT1", "MAP1B", "MAP2K1", "MAPRE2", "MARS", "MAT2A", "MATR3", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "MECP2", "MFN2", "MIA3", "MICU1", "MID1", "MIF", "MINPP1", "MMAB", "MOGS", "MPI", "MRE11", "MRPL12", "MRPL3", "MRPL44", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS34", "MRPS35", "MRPS7", "MSH2", "MSH3", "MSH6", "MSN", "MTAP", "MTCH1", "MTHFD1", "MTOR", "MTPAP", "MTR", "MTX2", "MYH14", "MYH9", "MYO6", "NAA15", "NADK2", "NAGLU", "NANS", "NARS", "NAXE", "NCAPD2", "NCAPH", "NCSTN", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFB11", "NDUFB3", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NEDD4L", "NEFL", "NEK9", "NEMF", "NEU1", "NHLRC2", "NHP2", "NIPBL", "NNT", "NONO", "NOP56", "NPC1", "NPC2", "NPM1", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NT5C2", "NUMA1", "NUP107", "NUP133", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP37", "NUP62", "NUP85", "NUP88", "NUP93", "OAT", "OCLN", "OGDH", "OGT", "OPA1", "OPA3", "P3H1", "P4HA2", "P4HB", "PABPN1", "PAFAH1B1", "PALLD", "PARK7", "PARN", "PBRM1", "PC", "PCCA", "PCCB", "PCNA", "PDCD6", "PDHA1", "PDHB", "PDHX", "PDK3", "PEPD", "PEX14", "PFKM", "PFN1", "PGK1", "PGM1", "PGM3", "PHB", "PHF6", "PHGDH", "PHIP", "PICALM", "PIGS", "PIGT", "PISD", "PITRM1", "PLAA", "PLD3", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLD1", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR3A", "PON2", "POP1", "POR", "PPA2", "PPIB", "PPIL1", "PPP2R1A", "PPP2R5D", "PPT1", "PQBP1", "PRCC", "PREPL", "PRKACA", "PRKAR1A", "PRKCSH", "PRKDC", "PRPF3", "PRPF31", "PRPF4", "PRPF6", "PRPF8", "PSAT1", "PSMB4", "PSMC3", "PSMD12", "PSMG2", "PTCD3", "PTDSS1", "PTPN1", "PTRH2", "PUF60", "PURA", "PUS1", "PUS7", "PXMP2", "PYCR1", "PYCR2", "PYGL", "QARS", "QRSL1", "RAB18", "RAB3GAP1", "RAB3GAP2", "RAB7A", "RAC1", "RAD21", "RAD50", "RALA", "RANBP2", "RARS", "RARS2", "RBM10", "RBM12", "RBM28", "RBM8A", "RBMX", "RDH11", "RDX", "REPS1", "RFC1", "RFC2", "RHOA", "RINT1", "RIPK1", "RNASEH2A", "RNASET2", "RP2", "RPL10", "RPL11", "RPL13", "RPL15", "RPL18", "RPL21", "RPL27", "RPL31", "RPL35", "RPL35A", "RPL5", "RPS10", "RPS14", "RPS15A", "RPS17", "RPS19", "RPS20", "RPS23", "RPS24", "RPS28", "RPS6KA3", "RPS7", "RPSA", "RRP7A", "RTN4IP1", "SAMHD1", "SARS", "SARS2", "SBDS", "SCAF1", "SCARB2", "SCO1", "SCP2", "SDHA", "SDHB", "SEC23A", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEPT9", "SERPINB6", "SERPINH1", "SET", "SF3B1", "SF3B4", "SGPL1", "SH3GL1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SKIV2L", "SLC12A2", "SLC16A1", "SLC19A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC27A4", "SLC33A1", "SLC9A3R1", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC3", "SMCHD1", "SMN1*", "SMPD4", "SNAP29", "SNRNP200", "SNRPE", "SON", "SPART", "SPATA5", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SQSTM1", "SRCAP", "SRP54", "SRP72", "SRSF2", "SSBP1", "SSR4", "STAG2", "STAT3", "STEAP3", "STT3A", "STT3B", "STUB1", "SUCLA2", "SUCLG1", "SUZ12", "SYNE2", "TACO1", "TAF15", "TALDO1", "TAP1", "TAP2", "TARDBP", "TARS", "TARS2", "TBCE", "TBL2", "TCOF1", "TDP2", "TECR", "TELO2", "TFAM", "TFG", "TFRC", "THG1L", "THOC2", "THOC6", "TIA1", "TIMM50", "TIMMDC1", "TJP2", "TKT", "TMCO1", "TMEM126A", "TMEM126B", "TMEM43", "TMPO", "TMPO", "TMTC3", "TMX2", "TOE1", "TOMM40", "TOP2A", "TOR1AIP1", "TP53", "TPI1", "TPM3", "TPP1", "TPP2", "TRAPPC11", "TRIM28", "TRIP12", "TRIP13", "TRMT10C", "TRMU", "TRNT1", "TSC2", "TSFM", "TTC19", "TTC21B", "TTC37", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "UBA1", "UBE4A", "UBR7", "UBTF", "UFC1", "UFD1", "UGDH", "UGP2", "UMPS", "UNC45A", "UNG", "UPF3B", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USMG5", "USP7", "USP8", "USP9X", "VAMP7", "VAPB", "VARS1", "VARS2", "VCL", "VCP", "VIM", "VPS13A", "VPS16", "VPS33A", "VPS33B", "VPS35", "VPS51", "VPS53", "VRK1", "WARS", "WBP11", "WDR1", "WDR11", "WDR36", "WDR4", "WDR45B", "WFS1", "WRAP53", "XRCC1", "YARS", "YARS2", "YEATS2", "YME1L1", "YWHAE", "YWHAG", "ZC3H14", "ZCCHC8", "ZFR", "ZMPSTE24", "ZNF148", "ZNF687"], "leading_proteins": ["ABCB1", "ABCD3", "ACP2", "ACTN1", "ADH5", "ADNP", "AIFM1", "AIP", "AKT2", "ANAPC1", "ANKRD17", "ANLN", "AP2M1", "AP3B1", "AP3D1", "APOL2", "APP", "APRT", "ARCN1", "ARPC1B", "ASAH1", "ATP6AP1", "ATP6V0A2", "ATXN10", "B4GAT1", "BLM", "BRCA1", "C1QBP", "CALR", "CARS", "CAST", "CD2AP", "CDC42", "CDK4", "CHORDC1", "CHST14", "CLN5", "CNOT1", "COPB2", "COX2", "COX5A", "CSNK2B", "CTNNB1", "CTPS1", "CTSA", "DCPS", "DCTN1", "DDOST", "DDX3X", "DDX41", "DHCR24", "DHCR7", "DKC1", "DNAAF5", "DNAJC3", "DNM1L", "DNMT1", "DSG2", "ECE1", "EEF1A2", "EFL1", "EIF4G1", "EIF4H", "EMD", "ERLIN2", "EWSR1", "EXOSC1", "FAH", "FAR1", "FARSA", "FASN", "FDPS", "FHL1", "FKBP10", "FKBP14", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FRG1", "FUS", "FXR1", "GAA", "GALNT2", "GBA", "GCDH", "GLA", "GLB1", "GLMN", "GM2A", "GNS", "GUSB", "HCCS", "HERC2", "HEXA", "HEXB", "HLA-A", "HLA-B", "HLA-C", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HPRT1", "HPS6", "HSD17B4", "HTRA2", "HUWE1", "HYOU1", "IDH1", "IFT27", "IGF2R", "IRS4", "ITCH", "KDM1A", "KDM3B", "KIF11", "KIF22", "KIF23", "KIFBP", "KMT2A", "LBR", "LEMD3", "LIPA", "LLGL1", "LRPAP1", "MAPRE2", "MCM4", "MDH1", "MECP2", "MFN2", "MRPL3", "MRPS25", "MRPS34", "MSH2", "MSH6", "MTAP", "MTHFD1", "MTOR", "MTR", "MYH14", "MYH9", "NAGLU", "NANS", "NCSTN", "NDUFAF4", "NDUFB3", "NDUFS2", "NECAP1", "NEU1", "NIPBL", "NNT", "NPC1", "NPC2", "NUP188", "NUP37", "OPA1", "P3H1", "P4HA2", "PCNA", "PDCD6", "PDK3", "PEX14", "PHF6", "PISD", "PLAA", "PLD3", "PLEC", "PLOD3", "PNP", "POLE", "POLR1C", "POLR3A", "PON2", "POR", "PPP2R5D", "PPT1", "PQBP1", "PREPL", "PRKACA", "PRKAR1A", "PRPF3", "PSAT1", "PSMG2", "PTDSS1", "PTRH2", "PUF60", "PURA", "PYGL", "QRSL1", "RAB18", "RAB3GAP1", "RAB3GAP2", "RAC1", "RALA", "RBM10", "RBM8A", "RFC1", "RINT1", "RIPK1", "RNASET2", "RPL10", "RPS14", "RPS17", "RPS20", "RPS23", "RPSA", "SAMHD1", "SARS2", "SCARB2", "SDHB", "SEC31A", "SET", "SF3B1", "SF3B4", "SKIV2L", "SLC12A2", "SLC19A1", "SLC25A13", "SLC25A15", "SLC25A20", "SLC25A24", "SLC25A32", "SLC27A4", "SMARCA4", "SMARCAD1", "SMC1A", "SNAP29", "SPART", "SPEN", "SPTLC1", "SQSTM1", "SRCAP", "SRP54", "SSR4", "STAG2", "STEAP3", "SUCLG1", "TAF15", "TAP2", "TBCE", "TELO2", "TFRC", "TIMMDC1", "TJP2", "TMCO1", "TMX2", "TOMM40", "TP53", "TPP1", "TPP2", "TRAPPC11", 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setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 +Lysosome 25 40 4.309692878089011 1.6348142252819997e-05 21.740291262135923 48.609223300970875 0.8281821627988494 0.1302152537326229 7.142313942893836 4.247239237941681 3.086075071395461 0.2389623217115766 3.0444525295319207e-30 5.439877808941605e-31 1.2283024585171612e-22 1.8724906191509258e-17 +Galactose metabolism 2 13 2.336829149765586 0.0194480694962686 4.58252427184466 13.216019417475728 -0.1782313827276002 0.4435757909481123 2.9055496675792862 0.5161805957123455 1.1764125997304256 0.3166437961140673 8.597904339497348e-05 0.0006712136127385 0.0008110696558398 0.0099569143851569 +Sphingolipid metabolism 5 10 2.275364632261116 0.0228840651920876 5.672330097087379 11.759708737864075 0.9805985471070467 0.1821702203806468 2.452838935293596 1.3449033287601222 1.7625559835482287 0.2542774311591588 0.0002365528693072 1.1653357867839908e-07 2.394767280194813e-05 0.0001416051152665 +Other glycan degradation 5 6 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0000000000000000000000000000000000000000..c915bfa78de5551557f664290b6a402001ba8d7e --- /dev/null +++ b/msigdb_kegg/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2453, + "annotations_size": 178, + "title": "Average number of proteins per term", + "value": 12.831460674157304 +} \ No newline at end of file diff --git a/msigdb_kegg/paths.json b/msigdb_kegg/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..8c986e1b8466f52f9997960e4bd5cfb62ef7a6e4 --- /dev/null +++ b/msigdb_kegg/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_kegg/fragment/C334/C334_val_log2fc"} \ No newline at end of file diff --git a/msigdb_kegg/result.tsv b/msigdb_kegg/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..1e943c108b0bf412d60bf385d9d402006255f0cc --- /dev/null +++ b/msigdb_kegg/result.tsv @@ -0,0 +1,64 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size 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0.998472108029816 0.2652998269717758 6 P06865,P07686,P54802,P16278,P15586 5 +Cell adhesion molecules cams 0.845161880022642 2.0338292091895105 0.0419688184199769 0.9995151842419696 0.2791780886058154 8 P10321,Q92692,Q9Y624,Q92896,P05556 5 +O glycan biosynthesis 0.9277551020408156 1.9754282823489304 0.0482195658735318 0.999848802175712 0.2871718644897066 3 Q10472,O43505 2 +Renin angiotensin system 0.904518735773416 1.8794476245712473 0.0601833986839026 0.9999840898603328 0.3273970474930787 4 Q9UIQ6 1 +Glycosphingolipid biosynthesis ganglio series 0.9010131366547424 1.8662834032801392 0.0620017255583891 0.9999887289851752 0.3273970474930787 4 P06865,P16278 2 +Epithelial cell signaling in helicobacter pylori infection 0.672684279534958 1.8035497049713949 0.0713019266980059 0.9999980872027876 0.343020079790407 15 Q9Y624,Q93050,Q15904,Q9Y487 4 +Adherens junction 0.5964748376283596 1.5281709662570528 0.1264700953710307 0.9999999999647268 0.5346261792688917 17 Q9UQB8,P67870 2 +Antigen processing and presentation 0.5904533139019656 1.4969603298372804 0.1344035806296404 0.9999999999930472 0.5346261792688917 17 P10321,Q99538,P01889 3 +Axon guidance 0.5842463044714058 1.4647115022889086 0.1429996454193558 0.9999999999988234 0.5373200084676412 17 O94813,Q15375 2 +Vibrio cholerae infection 0.5746202079424255 1.4593205134504428 0.1444769119587148 0.9999999999991346 0.5373200084676412 18 P55011,P61421,Q15904,Q9Y487,P24390,Q93050 6 +Allograft rejection 0.7854902784067952 1.42571287565919 0.153951238381178 0.9999999999998808 0.5373200084676412 4 P10321,P01889 2 +Graft versus host disease 0.7854902784067952 1.42571287565919 0.153951238381178 0.9999999999998808 0.5373200084676412 4 P10321,P01889 2 +Autoimmune thyroid disease 0.7854902784067952 1.42571287565919 0.153951238381178 0.9999999999998808 0.5373200084676412 4 P10321,P01889 2 +Starch and sucrose metabolism 0.6073237145344605 1.388434806422192 0.1650046837477217 0.9999999999999886 0.564823725136432 13 P08236,P10253 2 +Amino sugar and nucleotide sugar metabolism 0.5099630591740494 1.257446023954368 0.2085921725104982 1.0 0.6362154920297128 22 P06865 1 +Endocytosis 0.4847310751187245 1.2511481918358929 0.210880415897489 1.0 0.6362154920297128 31 P61020,P04439,Q9H4M9,P10321,Q96J02,Q9Y3E7,P02786,P01889,Q96CW1 9 +Notch signaling pathway 0.6691791928854742 1.159079407091826 0.2464238190026733 1.0 0.706275657744734 7 Q92542,Q13573 2 +Rig i like receptor signaling pathway 0.7155543496632747 1.1496402360329752 0.2502920788258163 1.0 0.706275657744734 3 Q13546 1 +Steroid biosynthesis 0.6246320987702896 1.140827271287654 0.2539418095261965 1.0 0.706275657744734 8 P38571,Q9UBM7 2 +Type i diabetes mellitus 0.6895951323890951 1.0848854567464543 0.2779723900034772 1.0 0.7518426927518062 5 P10321,P01889 2 +Natural killer cell mediated cytotoxicity 0.599916334161099 1.038776991828877 0.2989084642996218 1.0 0.7600815235047526 8 P10321,P01889,P04439 3 +Pentose and glucuronate interconversions 0.666900024938746 0.998765238626034 0.317908428988547 1.0 0.7742875816769 5 P08236 1 +Apoptosis 0.5168466861107509 0.9266883842296068 0.3540883502189238 1.0 0.8177693879440624 12 Q9UHD1,P04637,P17655,P31751,P17612,O95831,Q13546 7 +Viral myocarditis 0.5120002096963991 0.8482104556663544 0.3963207753554556 1.0 0.8499409399189289 10 Q04637,P04439,P10321,P01889,P35580,P35579 6 +Tight junction 0.4076421810355793 0.7233360857641475 0.4694734278516819 1.0 0.8832809498134141 30 Q9UDY2,P67870,Q14247,Q16625,Q9Y624,P31751,Q15334,P35579 8 +Snare interactions in vesicular transport 0.5149674260791053 0.6951875705974466 0.4869377606717235 1.0 0.8832809498134141 8 P51809,Q86Y82 2 +Hedgehog signaling pathway 0.5919543042394309 0.680441023904936 0.4962252527041653 1.0 0.8832809498134141 3 P48729 1 +Pathogenic escherichia coli infection 0.3968193790829415 0.5615328062079803 0.5744343724945828 1.0 0.9380671404039976 20 Q14247,Q16625,Q9BUF5,O15143,P07437,P68371,P05556,P27348 8 +Alzheimers disease 0.3462915360118433 0.4393389355773486 0.6604159658992663 1.0 1.0 46 P05067,Q92542 2 +Proximal tubule bicarbonate reclamation 0.4679357110945633 0.4121937029811068 0.6801974522458538 1.0 1.0 7 P05026 1 +Erbb signaling pathway 0.4061218663326577 0.411154933409779 0.6809589314973716 1.0 1.0 10 O96013,Q13177,P31751,P42345 4 +Leukocyte transendothelial migration 0.3741458570707315 0.4007010387109666 0.6886402459612992 1.0 1.0 18 Q9Y624 1 +Selenoamino acid metabolism 0.4636140637776068 0.3984325204899504 0.6903113901149083 1.0 1.0 7 O43252,P23526,P31153,O43865,O43709,P49903 6 +Chronic myeloid leukemia 0.3910903047015611 0.3677450482289319 0.7130633470586503 1.0 1.0 11 Q13547,P31751,P62993 3 +Aldosterone regulated sodium reabsorption 0.4748792103224592 0.3439650364928301 0.7308725803744061 1.0 1.0 6 Q9Y3B8,P54709,P05026 3 +Pancreatic cancer 0.3854765653491763 0.3271190588067429 0.7435778372709123 1.0 1.0 9 P11233 1 +Renal cell carcinoma 0.3729673251983281 0.3019445998667109 0.7626942957439999 1.0 1.0 11 O96013,P31751,Q13177,P62993 4 +Focal adhesion 0.337807210625963 0.2919687319287905 0.7703105311471581 1.0 1.0 25 Q13177,O96013,P17655,P31751,P05556,P62993,Q14315 7 +T cell receptor signaling pathway 0.3549523283328872 0.2351583313092237 0.8140858459704352 1.0 1.0 10 O96013,Q13177,P31751 3 +Porphyrin and chlorophyll metabolism 0.3511422377416091 0.2234989942991184 0.8231471657673977 1.0 1.0 10 P08236 1 +Neurotrophin signaling pathway 0.3245646696665659 0.2180016999384035 0.8274277869211573 1.0 1.0 23 Q99523,P27348 2 +Nitrogen metabolism 0.4355102040816284 0.2136348990828982 0.8308317820917217 1.0 1.0 3 P08243,P00367 2 +Small cell lung cancer 0.396334281655624 0.2092888827526196 0.8342227298914879 1.0 1.0 7 P05556 1 +Fc epsilon ri signaling pathway 0.4299999169245651 0.2089800098674934 0.8344638438919239 1.0 1.0 4 P31751 1 +Wnt signaling pathway 0.3248923609867755 0.2044430625355132 0.8380072817023849 1.0 1.0 20 Q14738,Q9HB71,P67870,P48729,O75116,P63208,P17612 7 +Arrhythmogenic right ventricular cardiomyopathy arvc 0.3369333433756592 0.1848920601670912 0.8533136986942116 1.0 1.0 11 Q14126 1 +Hypertrophic cardiomyopathy hcm 0.4064341839219444 0.1745336583603335 0.8614460811396165 1.0 1.0 5 P05556 1 +Gap junction 0.3308269308338662 0.1671374066992865 0.8672619336726983 1.0 1.0 11 Q9BUF5,P07437,P68371,P17612,P62993 5 +Cardiac muscle contraction 0.3139091036107713 0.137833645472971 0.890371892891624 1.0 1.0 17 P54709,P14406,P05026 3 +Proteasome 0.3075656302968086 0.1316681295006926 0.8952467949725884 1.0 1.0 35 P28072,P49721 2 +Non small cell lung cancer 0.3688402168374679 0.108923386377287 0.9132632573568796 1.0 1.0 6 Q00534,P31751,P62993,P04637 4 +Dilated cardiomyopathy 0.3580194960756719 0.0928155038906057 0.9260501338570246 1.0 1.0 6 P05556 1 +B cell receptor signaling pathway 0.3510122045829201 0.083190866579139 0.9336997749803202 1.0 1.0 6 P31751,P62993 2 +Vasopressin regulated water reabsorption 0.297443532772684 0.0780294722303251 0.9378046090086204 1.0 1.0 13 P61020,Q14203,Q9UJW0,P17612,P63167 5 +Cytosolic dna sensing pathway 0.3191492905663228 0.0471642963983128 0.9623822831851973 1.0 1.0 6 O15160,Q13546 2 +Tgf beta signaling pathway 0.3135520915639113 0.042085086745226 0.9664308686914596 1.0 1.0 6 O75116,Q7Z3T8 2 +Glioma 0.2526350371396169 0.0202307081948236 0.9838593312977468 1.0 1.0 9 P31751,P42345 2 +Regulation of actin cytoskeleton 0.2817785001294933 0.0009878045853571 0.9992118461004278 1.0 1.0 36 Q13177,O96013,Q9UQB8,O15143,O75116,P05556,P35579 7 diff --git a/msigdb_kegg/selections.json b/msigdb_kegg/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..cbc84566ae9e050eb362a2c756ffef810aeae3ec --- /dev/null +++ b/msigdb_kegg/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Abc transporters", "Acute myeloid leukemia", "Adherens junction", "Adipocytokine signaling pathway", "Alanine aspartate and glutamate metabolism", "Aldosterone regulated sodium reabsorption", "Allograft rejection", "Alpha linolenic acid metabolism", "Alzheimers disease", "Amino sugar and nucleotide sugar metabolism", "Aminoacyl trna biosynthesis", "Amyotrophic lateral sclerosis als", "Antigen processing and presentation", "Apoptosis", "Arachidonic acid metabolism", "Arginine and proline metabolism", "Arrhythmogenic right ventricular cardiomyopathy arvc", "Ascorbate and aldarate metabolism", "Autoimmune thyroid disease", "Axon guidance", "B cell receptor signaling pathway", "Basal cell carcinoma", "Basal transcription factors", "Base excision repair", "Beta alanine metabolism", "Biosynthesis of unsaturated fatty acids", "Bladder cancer", "Butanoate metabolism", "Calcium signaling pathway", "Cardiac muscle contraction", "Cell adhesion molecules cams", "Cell cycle", "Chemokine signaling pathway", "Chronic myeloid leukemia", "Citrate cycle tca cycle", "Colorectal cancer", "Cysteine and methionine metabolism", "Cytokine cytokine receptor interaction", "Cytosolic dna sensing pathway", "Dilated cardiomyopathy", "Dna replication", "Dorso ventral axis formation", "Drug metabolism cytochrome p450", "Drug metabolism other enzymes", "Ecm receptor interaction", "Endocytosis", "Endometrial cancer", "Epithelial cell signaling in helicobacter pylori infection", "Erbb signaling pathway", "Ether lipid metabolism", "Fatty acid metabolism", "Fc epsilon ri signaling pathway", "Fc gamma r mediated phagocytosis", "Focal adhesion", "Folate biosynthesis", "Fructose and mannose metabolism", "Galactose metabolism", "Gap junction", "Glioma", "Glutathione metabolism", "Glycerolipid metabolism", "Glycerophospholipid metabolism", "Glycine serine and threonine metabolism", "Glycolysis gluconeogenesis", "Glycosaminoglycan biosynthesis chondroitin sulfate", "Glycosaminoglycan biosynthesis keratan sulfate", "Glycosaminoglycan degradation", "Glycosphingolipid biosynthesis ganglio series", "Glycosphingolipid biosynthesis globo series", "Glycosphingolipid biosynthesis lacto and neolacto series", "Glycosylphosphatidylinositol gpi anchor biosynthesis", "Glyoxylate and dicarboxylate metabolism", "Gnrh signaling pathway", "Graft versus host disease", "Hedgehog signaling pathway", "Hematopoietic cell lineage", "Histidine metabolism", "Homologous recombination", "Huntingtons disease", "Hypertrophic cardiomyopathy hcm", "Inositol phosphate metabolism", "Insulin signaling pathway", "Jak stat signaling pathway", "Leishmania infection", "Leukocyte transendothelial migration", "Limonene and pinene degradation", "Long term depression", "Long term potentiation", "Lysine degradation", "Lysosome", "Mapk signaling pathway", "Maturity onset diabetes of the young", "Melanogenesis", "Melanoma", "Metabolism of xenobiotics by cytochrome p450", "Mismatch repair", "Mtor signaling pathway", "N glycan biosynthesis", "Natural killer cell mediated cytotoxicity", "Neurotrophin signaling pathway", "Nicotinate and nicotinamide metabolism", "Nitrogen metabolism", "Nod like receptor signaling pathway", "Non homologous end joining", "Non small cell lung cancer", "Notch signaling pathway", "Nucleotide excision repair", "O glycan biosynthesis", "Olfactory transduction", "One carbon pool by folate", "Oocyte meiosis", "Other glycan degradation", "Oxidative phosphorylation", "P53 signaling pathway", "Pancreatic cancer", "Pantothenate and coa biosynthesis", "Parkinsons disease", "Pathogenic escherichia coli infection", "Pathways in cancer", "Pentose and glucuronate interconversions", "Pentose phosphate pathway", "Peroxisome", "Phenylalanine metabolism", "Phosphatidylinositol signaling system", "Porphyrin and chlorophyll metabolism", "Ppar signaling pathway", "Primary bile acid biosynthesis", "Primary immunodeficiency", "Prion diseases", "Progesterone mediated oocyte maturation", "Propanoate metabolism", "Prostate cancer", "Proteasome", "Protein export", "Proximal tubule bicarbonate reclamation", "Purine metabolism", "Pyrimidine metabolism", "Pyruvate metabolism", "Regulation of actin cytoskeleton", "Regulation of autophagy", "Renal cell carcinoma", "Renin angiotensin system", "Retinol metabolism", "Riboflavin metabolism", "Ribosome", "Rig i like receptor signaling pathway", "Rna degradation", "Rna polymerase", "Selenoamino acid metabolism", "Small cell lung cancer", "Snare interactions in vesicular transport", "Sphingolipid metabolism", "Spliceosome", "Starch and sucrose metabolism", "Steroid biosynthesis", "Steroid hormone biosynthesis", "Sulfur metabolism", "Systemic lupus erythematosus", "T cell receptor signaling pathway", "Taste transduction", "Terpenoid backbone biosynthesis", "Tgf beta signaling pathway", "Thyroid cancer", "Tight junction", "Toll like receptor signaling pathway", "Tryptophan metabolism", "Type i diabetes mellitus", "Type ii diabetes mellitus", "Tyrosine metabolism", "Ubiquitin mediated proteolysis", "Valine leucine and isoleucine biosynthesis", "Valine leucine and isoleucine degradation", "Vascular smooth muscle contraction", "Vasopressin regulated water reabsorption", "Vegf signaling pathway", "Vibrio cholerae infection", "Viral myocarditis", "Wnt signaling pathway"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ACAA2", "ACACA", "ACACB", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN4", "ADAM17", "ADAR", "ADH5", "ADI1", "ADK", "ADSL", "ADSS", "AFDN", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AIFM1", "AK1", "AK2", "AKR1A1", "AKR1B1", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALYREF", "ANAPC1", "ANAPC5", "ANAPC7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEX1", "APP", "APRT", "ARFGAP1", "ARG2", "ARHGDIA", "ARHGEF2", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ATG4B", "ATIC", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "B4GAT1", "BAIAP2", "BCAS2", "BCAT2", "BIRC6", "BLM", "BLVRA", "BRCA1", "BUB1B", "BUB3", "BUD23", "CACYBP", "CAD", "CALD1", "CALR", "CAMK2D", "CAMK2G", "CANX", "CAPN1", "CAPN2", "CARS", "CBR1", "CCDC6", "CDC23", "CDC27", "CDC34", "CDC42", "CDC5L", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CFL1", "CFL2", "CHERP", "CHKA", "CHMP3", "CHORDC1", "CHST14", "CKB", "CKMT1A*", "CLN5", "CLTC", "CMAS", "CMPK1", "CNOT1", "CNOT10", "CNOT3", "CNOT6", "CNOT7", "CNOT9", "COMT", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPOX", "CPT2", "CRKL", "CRNKL1", "CS", "CSK", "CSNK1A1", "CSNK2B", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CWC15", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DARS", "DARS2", "DCPS", "DCTN1", "DCTN2", "DCTN4", "DCXR", "DDB1", "DDOST", "DDX23", "DDX39B", "DDX3X", "DDX42", "DDX46", "DDX5", "DDX6", "DERL1", "DFFA", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX38", "DHX8", "DIAPH1", "DIAPH3", "DIS3", "DLAT", "DLD", "DLST", "DNM1L", "DNM2", "DNMT1", "DPM1", "DPYSL2", "DSG2", "DSP", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "ECH1", "ECHS1", "ECI2", "ECSIT", "EDC3", "EDC4", "EFTUD2", "EHD1", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "ELOB", "EMD", "ENAH", "ENO1", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPRS", "ERCC2", "ERCC3", "ERO1A", "EXO1", "EXOC3", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "F11R", "FADS2", "FAH", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FECH", "FEN1", "FH", "FLAD1", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FUCA2", "G6PD", "GAA", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GARS", "GART", "GBA", "GCAT", "GCDH", "GFPT1", "GGCT", "GGH", "GLA", "GLB1", "GLDC", "GLG1", "GLO1", "GLS", "GLUD1", "GM2A", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNPAT", "GNPDA1", "GNS", "GOT1", "GOT2", "GPAA1", "GPD2", "GPI", "GRB2", "GRHPR", "GSK3A", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2I", "GUSB", "GYS1", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HADH", "HADHA", "HADHB", "HCCS", "HDAC1", "HDAC2", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HMGB1", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA3", "HNRNPC", "HNRNPK", "HNRNPM", "HNRNPU", "HPRT1", "HSD17B10", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA1B", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HTRA2", "HTT", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IGF2BP1", "IGF2R", "ILK", "IMPDH2", "IQGAP1", "IRS4", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KDELR1", "KDSR", "KEAP1", "L2HGDH", "LAMP1", "LAP3", "LARS", "LARS2", "LDHA", "LDHB", "LGMN", "LIG3", "LIPA", "LLGL1", "LMNA", "LNPEP", "LPCAT1", "LSM2", "LSM6", "LSS", "LTA4H", "LYPLA1", "MAP2K1", "MARCKS", "MARCKSL1", "MARS", "MAT2A", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "ME1", "ME2", "MGST2", "MGST3", "MID1", "MIF", "MINPP1", "MMAB", "MOGS", "MPI", "MPST", "MRE11", "MSH2", "MSH3", "MSH6", "MSN", "MTAP", "MTCH1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR6", "MTOR", "MTR", "MYH10", "MYH14", "MYH9", "MYL6", "NAGK", "NAGLU", "NAMPT", "NANS", "NARS", "NCBP1", "NCKAP1", "NCL", "NCSTN", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA9", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEU1", "NLN", "NME1", "NNT", "NPC1", "NPC2", "NSD2", "NSDHL", "NSF", "NT5C2", "NUDT12", "NUDT5", "NUDT9", "OAT", "OCLN", "OGDH", "P4HA1", "P4HA2", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK2", "PAK4", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARN", "PARP1", "PARP2", "PC", "PCBP1", "PCCA", "PCCB", "PCNA", "PDCD6", "PDCD6IP", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PECR", "PEX14", "PFAS", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PHF5A", "PHGDH", "PI4KB", "PIGS", "PIGT", "PISD", "PKM", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PMPCA", "PNP", "PNPT1", "POLD1", "POLDIP2", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "PPA1", "PPA2", "PPAT", "PPID", "PPIH", "PPIL1", "PPP1CA", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PPT1", "PQBP1", "PRDX5", "PRDX6", "PRIM1", "PRIM2", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF6", "PRPF8", "PSAT1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", 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4.192861933829232 2.1968580551223003 2.1941615995620167 0.2567064655985949 1.766711085287536e-08 3.672346218037715e-10 2.499562823899845e-07 3.731064749720328e-05 +Transport of small molecules 20 129 2.878992729557877 0.003989475312083 41.730582524271846 151.96601941747574 1.4265613612661356 0.380396759556163 14.87709311863932 12.598305121005488 1.746958952072276 0.4128488770716938 0.0098773233595845 0.0011289483032464 0.0001357728542561 0.0001861749625189 +Trans golgi network vesicle budding 5 28 2.75887351426685 0.0058000979731454 10.53640776699029 36.62378640776699 0.049458611821428 0.5755399655007756 4.812618396852807 3.083264760841391 1.1838693038940356 0.3533924794481698 9.67830310177096e-07 5.5694737187114106e-05 0.0002610712120791 0.0061224763867012 +Glycosphingolipid metabolism 8 14 2.692479380944878 0.0070922920877267 7.514563106796117 15.521844660194176 0.6340330218232789 0.1371235236408302 2.3948329397108954 1.2175929202976112 2.2116324239586063 0.2290247571497847 1.7086834647982223e-10 1.848272761081035e-11 6.182018790428762e-08 2.363654774029087e-06 +Diseases of glycosylation 6 14 2.689334571550167 0.007159462281439 6.359223300970874 19.17718446601942 0.13180823173309 0.3045208720095976 2.4657040544471793 2.991113672999948 1.5111068586159069 0.284004628008759 1.7197784900320366e-06 9.611170637388942e-05 0.0024819922622898 0.0770198920563529 +Glycosaminoglycan metabolism 7 11 2.6259989946954714 0.0086395072551419 6.563106796116505 14.388349514563108 0.750167459040055 0.1742505874253542 2.387954817808654 2.3973407990867264 1.8682770414846892 0.2409021330213527 2.2001184078103924e-05 5.108513247302564e-06 0.0002886408637045 0.0067309962323406 +Plasma lipoprotein assembly remodeling and clearance 3 12 2.613699473719044 0.0089567782230919 3.495145631067961 16.83495145631068 -0.156267225907303 0.3789468896930614 2.0090754595317124 2.280551318877052 1.3521243953392292 0.296420660396241 0.0009649225463882 0.0006071735045487 0.0159331781494728 0.129535631100319 +Cargo recognition for clathrin mediated endocytosis 4 23 2.5822788522136984 0.0098150244032213 8.473300970873787 32.9126213592233 0.0802035091430913 0.5538966462673686 4.054455271697202 4.1286514785567014 1.088296749159732 0.3439390512580828 0.0065211094409693 0.0410498464156044 0.0417227578986097 0.1806745224652408 +Plasma lipoprotein clearance 3 10 2.576388043358673 0.0099838531549092 2.8980582524271843 13.347087378640778 -0.2018368930286127 0.3332067151933208 1.7692892864455283 1.6527165816198162 1.437154699054494 0.2826032943885157 0.0001834080308804 6.684645425207902e-05 0.0021324559374895 0.0237749620613201 +Metabolism of carbohydrates 8 83 2.470426868617285 0.0134951909032903 24.106796116504853 96.5728155339806 -0.5221362188572046 0.5396051441609171 9.448031203305042 5.564453656914835 0.9880396829037232 0.3520896380798738 0.0004202884338454 0.0007831431684808 0.0103261806002204 0.0193034969615419 +Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 4 15 2.4249248278279167 0.0153115568714572 6.014563106796117 17.274271844660195 0.870961683103299 0.329566970411291 2.8591161566949044 2.4465188670593117 1.2657234914365352 0.3108311955329007 0.0025622817609439 0.0002109253407302 0.0115741629942865 0.018559369180974 +Metabolism of lipids 19 126 2.399519657501308 0.0164165983433663 47.21601941747573 182.9902912621359 0.7669400545274999 0.4573741022352977 16.76057659641467 20.451455734561765 1.5920609507025254 0.4091924181498379 0.0001461124316895 3.904196164745111e-07 0.0014686308497229 0.116832406758842 +Ion channel transport 9 24 2.3938085202598285 0.0166744512174135 9.031553398058252 27.74271844660194 0.8980727715308076 0.3472480807052641 4.2752930421976005 3.4432740668393595 1.4212023690700646 0.3452897078102002 0.0610672127355571 0.046481015474091 0.014921436170793 0.0005889186169691 +Response to elevated platelet cytosolic ca2 3 25 2.338471761930298 0.0193627888652754 8.235436893203884 32.09466019417476 0.5218742391064733 0.474727643525593 3.081483464681404 3.343341539765611 1.0584548796008648 0.3324549758990046 0.0050180872027471 0.0051214743942411 0.0952213329894842 0.1323780825119418 +Diseases of carbohydrate metabolism 4 8 2.296392822599005 0.0216534309900513 3.5024271844660193 9.050970873786408 0.3053509571481614 0.2820635836848948 1.390848707873377 1.194576753712748 1.470873952821233 0.2708232247081553 0.0001834080308804 2.400285967257217e-06 0.0001958127697586 0.0044081397545113 +Ldl clearance 2 8 2.254363740512304 0.0241732944199433 3.004854368932039 11.317961165048544 -0.7075477519664274 0.3458777987103926 1.8708223953925376 1.6050187424265143 1.3458663454313908 0.3268587514397556 0.0030581061915538 0.0005633424812776 0.0075942890928168 0.0472723399635447 +Iron uptake and transport 5 18 2.237072105615798 0.0252816277426344 4.089805825242719 17.9126213592233 1.0360420001787272 0.323786301352462 2.0477771422769826 0.9863810102632052 1.0014322629164618 0.2971986354372174 0.0148056693212618 0.0532804729840314 0.0002861284437042 0.0004087345815453 +Golgi associated vesicle biogenesis 6 25 2.2308951831313424 0.0256880728881399 8.759708737864077 29.70145631067961 0.0117084357140251 0.6100432040453254 4.8544872558395 2.3659596085838968 0.9746782938929878 0.3312452125247998 0.0001451753331012 0.0020253160845859 0.0021266925651856 0.0169271631671333 +Transferrin endocytosis and recycling 4 11 2.20665542066568 0.027338141922002 3.186893203883495 10.822815533980584 0.6564894823668704 0.3913498590234048 1.8751111444734605 0.7728172110534567 1.0012961103567426 0.2928480452979678 0.0034296220851759 0.0131546828557762 5.510228275490696e-05 0.000147824727769 +Keratan sulfate keratin metabolism 4 5 2.190117241878148 0.0285157350936233 3.1359223300970873 5.439320388349515 0.1148000450757159 0.1857420338858874 1.294488268568909 0.7592200419566036 1.8452752770630356 0.2520366769461069 1.36735146888872e-08 4.6250912861383714e-07 4.060119731401367e-05 0.0010331595236533 +Diseases associated with glycosylation precursor biosynthesis 2 8 2.1414196668941363 0.0322402103539489 2.504854368932039 7.854368932038835 -0.2470350872852216 0.3703940384904795 1.636203196770404 1.0039510972336867 1.211038284186021 0.274954505205811 5.941460259222129e-05 0.0004672463302539 0.0063676045893722 0.0403506671570748 +Mitophagy 6 11 2.1240460584606757 0.0336662923794952 3.662621359223301 11.783980582524272 1.3564301304992197 0.1917930287367771 1.8155907654273165 1.3363606860118669 1.2723890100166135 0.2636913304405313 1.0 0.0228441699597423 0.00251045639703 0.0001063915357976 +Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 2 14 2.1039478643315666 0.0353829950881787 5.206310679611651 19.733009708737864 0.0173546219692671 0.4747351478662189 2.6010936797167927 3.197629229480199 1.0505158678674285 0.2959489394818763 0.0029741493546945 0.0200220567053061 0.1743155882100804 0.5555158130103539 +Synthesis of substrates in n glycan biosythesis 2 13 2.090492650881765 0.0365735678760661 4.101941747572815 15.29126213592233 -0.0934295860101241 0.4651486832142111 2.554131645515961 2.6342813465607953 0.9880430361156176 0.2693319722460128 0.0012757726476668 0.009062215893767 0.0918272438847456 0.3646272656082709 +Ddx58 ifih1 mediated induction of interferon alpha beta 0 10 2.0774564963317075 0.0377594464623449 4.720873786407767 14.978155339805824 -0.0199452971729376 0.6329309408651904 3.372108788740253 3.2667802050196735 0.7611374145016976 0.2870699917981729 0.2449590299452383 0.4307061333231872 0.7566437763344733 0.5319437324359639 +Sialic acid metabolism 2 5 2.062918860917584 0.0391203378274847 1.633495145631068 4.638349514563107 0.3331729503932819 0.3039098658637086 1.1012545438565893 0.8492059078669172 1.3430882059420008 0.2726683810004117 5.941460259222129e-05 0.0004672463302539 0.0063676045893722 0.0403506671570748 +Eph ephrin mediated repulsion of cells 1 8 2.027037547053836 0.0426585729493176 4.461165048543689 11.228155339805824 -0.2944328331689875 0.630539547401474 2.942976929194092 1.8278810203110143 0.737148978307686 0.298883955001986 1.0 0.0663348012473392 0.2829018108703478 0.6281100642676263 +Toll like receptor cascades 1 17 2.02065698039691 0.0433152860325665 7.165048543689321 27.33009708737864 -0.2468232617077198 0.5651419273555431 4.038881627810941 4.339675504656963 0.9129292880958944 0.3127827796055167 0.090603000234403 0.2680066972469274 0.7212008828791847 0.5702977719780368 +Rac3 gtpase cycle 10 24 2.015076437642135 0.043896640647939 8.009708737864077 33.38834951456311 0.6317391478054292 0.5404727513867776 4.131914964564212 3.845266942414024 0.7932567036719335 0.3408212861634197 0.3361355940595682 0.0088607173186582 0.0521205227118809 0.0022479746963346 +Rac2 gtpase cycle 9 27 2.011908301480246 0.0442296041551104 8.905339805825243 34.74757281553398 0.8419178475366841 0.4471774138928159 4.131135699306596 3.707034631516275 0.9898490308362274 0.3561406142763811 0.3295231102555642 0.0450913351422118 0.1359283502231961 0.0058704042142295 +Extracellular matrix organization 8 24 1.981914173733005 0.047488847310356 7.808252427184466 28.75728155339806 0.0816457709205555 0.5705124899153677 3.3832296074989077 4.083392886365088 0.966248903682439 0.3167495885018867 0.4769824301569347 0.1375179432078189 0.1014313426487926 0.1072750433266705 +Pink1 prkn mediated mitophagy 4 9 1.9807839528421165 0.0476155071568391 3.2815533980582523 8.473300970873787 1.395617281862234 0.1554977461962819 1.6230588150315317 0.9738153254376878 1.3577427922485954 0.2414588001366878 1.0 0.0117676307173903 0.0075942890928168 0.0010331595236533 +Vesicle mediated transport 31 182 1.978425852921977 0.0478806856061606 58.50242718446602 249.35679611650485 0.124174647312522 0.774755156304532 21.341137946840067 25.302660695642658 0.8268707622329793 0.3241332030593034 0.0002630120590457 0.041134981166699 0.0037612352971877 4.855200255160772e-05 diff --git a/msigdb_reactome/metrics.json b/msigdb_reactome/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..b13b0482d3766adfd5f40adf8af13653e40441ad --- /dev/null +++ b/msigdb_reactome/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2453, + "annotations_size": 1317, + "title": "Average number of proteins per term", + "value": 16.760060744115414 +} \ No newline at end of file diff --git a/msigdb_reactome/paths.json b/msigdb_reactome/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..2f5963c24822bdd5737a93d2c47d441bb304e57c --- /dev/null +++ b/msigdb_reactome/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_reactome/fragment/C334/C334_val_log2fc"} \ No newline at end of file diff --git a/msigdb_reactome/result.tsv b/msigdb_reactome/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..ff0fb6cfb68840dae610371f6684f311fb999a55 --- /dev/null +++ b/msigdb_reactome/result.tsv @@ -0,0 +1,377 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Neutrophil degranulation 0.6193555322517424 3.907893112201576 9.3104476775574e-05 0.115404061091935 0.0046643048656144 144 O00584,P06280,P61916,Q9BTY2,P10253,P17900,P11717,P16278,P15586,Q99519,P11279,P07686,P10619,Q92820,Q92542,Q13510,P10321,P08236,P67870 19 +Innate immune system 0.5672198775061972 3.4772296433077035 0.0005066236948432 0.4869553901441542 0.0104253657204457 229 P05067,O00584,P06280,Q8IV08,Q99538,P61916,Q8TBC4,Q9BTY2,P10253,P17900,Q93050,P11717,P16278,P15586,Q99519,P11279,P60900,P07686,P10619,Q9Y487,Q92820,Q92542,Q13510,P30519,P49721,P10321,Q9UQB8,P01889,O15143,P08236,P28072,O95721,P67870,P49427,P42785,P84095,P17858,Q7Z6Z7 38 +Diseases of metabolism 0.7601717901019348 3.035914793055447 0.0023980712239823 0.9576612583138098 0.0303638605844384 33 P06865,Q99519,P07686,P10619,P10253,P54802,O43505,P08236,P16278,P15586 10 +Sphingolipid metabolism 0.8340087047588362 3.016574548286228 0.0025564834736029 0.9656515979628107 0.0303638605844384 22 P06865,Q99519,P06280,P07686,P10619,P17900,P04062,P16278,Q13510 9 +Transport of small molecules 0.5188221228983062 2.878992729557877 0.003989475312083 0.9948287848188836 0.0343407776863619 129 Q9C0H2,P61916,P02786,Q93050,Q658P3,Q8WTV0,Q15904,P60900,Q9Y487,O15118,P51790,Q9H2J7,P38571,P30519,P55011,P49721,P28072,P08195,Q8N4V1,P35613 20 +Trans golgi network vesicle budding 0.7410921815117174 2.75887351426685 0.0058000979731454 0.99952914847721 0.047742056441453 28 P05067,P02786,O75976,P11717,P15586 5 +Glycosphingolipid metabolism 0.8847874269567346 2.692479380944878 0.0070922920877267 0.9999150823911196 0.0560625206384571 14 P06865,Q99519,P06280,P07686,P10619,P17900,P16278,Q13510 8 +Diseases of glycosylation 0.8840407663267004 2.689334571550167 0.007159462281439 0.9999223211179438 0.0560625206384571 14 P06865,Q99519,P07686,P10619,O43505,P16278 6 +Cs ds degradation 0.9832721338229296 2.653654598125777 0.0079625286113813 0.9999732405603732 0.0616861775364073 2 P06865 1 +Glycosaminoglycan metabolism 0.9165418351228596 2.6259989946954714 0.0086395072551419 0.9999891100166672 0.0660933145113412 11 P06865,P07686,P54802,O43505,P08236,P16278,P15586 7 +Nrif signals cell death from the nucleus 0.974296205630355 2.61690222796692 0.008873175315931 0.9999920164427633 0.0671607579947192 2 Q92542 1 +Plasma lipoprotein assembly remodeling and clearance 0.8981958355939018 2.613699473719044 0.0089567782230919 0.999992855887156 0.0674061538274976 12 Q8WTV0,P61916,O15118 3 +Cargo recognition for clathrin mediated endocytosis 0.7369752859354463 2.5822788522136984 0.0098150244032213 0.9999977175056686 0.072620152466531 23 Q14108,P11717,Q8NC96,P02786 4 +Plasma lipoprotein clearance 0.9186635772467602 2.576388043358673 0.0099838531549092 0.9999981766084414 0.0734566179051143 10 Q8WTV0,P61916,O15118 3 +Formation of fibrin clot clotting cascade 0.9547123623011018 2.536210173287817 0.0112059457558419 0.9999996415739631 0.0793453255937844 2 Q07021 1 +Intrinsic pathway of fibrin clot formation 0.9547123623011018 2.536210173287817 0.0112059457558419 0.9999996415739631 0.0793453255937844 2 Q07021 1 +Metabolism of carbohydrates 0.5326878361872288 2.470426868617285 0.0134951909032903 0.999999983070066 0.0914558997047321 83 P06865,P07686,P10253,P54802,O43505,P08236,P16278,P15586 8 +Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.8066556216493433 2.4249248278279167 0.0153115568714572 0.9999999985052336 0.1018450525237838 15 Q9BTY2,P05067,Q06481,O43852 4 +Ecm proteoglycans 0.923296613627094 2.4053214150973834 0.016158247296349 0.9999999995185476 0.1060342703184681 2 P05067 1 +Metabolism of lipids 0.4752720465029422 2.3995196575013074 0.0164165983433663 0.999999999659326 0.1060342703184681 126 P06280,Q8IV08,Q99538,P17900,P50897,P16278,P06865,Q99519,P07686,P10619,Q13510,P35790,O43772,Q9UBM7,Q14849,Q15392,P04062,O15269,Q14739 19 +Ion channel transport 0.6912601882056106 2.3938085202598285 0.0166744512174135 0.9999999997588016 0.1066031662783184 24 P61421,Q9HD20,Q15904,P05026,Q9C0H2,Q9Y487,P54709,P51790,Q93050 9 +Synthesis of pe 0.9086087311301536 2.3435190836452153 0.0191027849612508 0.9999999999907072 0.1181144027885791 2 P35790 1 +Response to elevated platelet cytosolic ca2 0.678194911001279 2.338471761930298 0.0193627888652754 0.9999999999934458 0.1186083392351987 25 P05067,Q08380,Q06481 3 +Diseases of carbohydrate metabolism 0.9135031210481568 2.296392822599005 0.0216534309900513 0.9999999999996988 0.1284575162788181 8 P10253,P54802,P16278,P15586 4 +Ldl clearance 0.9024235473880994 2.2543637405123036 0.0241732944199433 0.99999999999999 0.1408682688100236 8 P61916,O15118 2 +Iron uptake and transport 0.7259842732529282 2.237072105615798 0.0252816277426344 0.9999999999999978 0.1453969595504346 18 Q15904,Q9Y487,P02786,Q93050,Q658P3 5 +Golgi associated vesicle biogenesis 0.6592240538067143 2.2308951831313424 0.0256880728881399 0.9999999999999988 0.1458241034210355 25 Q99523,P51809,P02786,Q8NC96,O75976,P11717 6 +Transferrin endocytosis and recycling 0.8131454377709977 2.2066554206656797 0.027338141922002 1.0 0.1532099272820283 11 Q93050,Q15904,P02786,Q658P3 4 +Keratan sulfate keratin metabolism 0.9844771241830066 2.190117241878148 0.0285157350936233 1.0 0.1577950551189159 5 P06865,P15586,P16278,O43505 4 +Keratan sulfate degradation 0.9840751327072272 2.1740933379332943 0.0296981261955568 1.0 0.1636503439311649 4 P06865,P16278,P15586 3 +Receptor mediated mitophagy 0.8616891064871521 2.1435502872005525 0.0320689376873681 1.0 0.1759782955594329 2 P67870 1 +Diseases associated with glycosylation precursor biosynthesis 0.8729181343823955 2.1414196668941363 0.0322402103539489 1.0 0.176184054091912 8 Q99519,P16278 2 +Mitophagy 0.7934004626708819 2.1240460584606753 0.0336662923794952 1.0 0.1792094486619531 11 Q13501,P67870,Q8IWA4,O96008,Q9NS69,Q8N4H5 6 +Hs gag degradation 0.9648979591836732 2.1157358344281443 0.0343672810573909 1.0 0.1796099569546979 3 P54802,P16278 2 +Heparan sulfate heparin hs gag metabolism 0.9648979591836732 2.1157358344281443 0.0343672810573909 1.0 0.1796099569546979 3 P54802,P16278 2 +Mucopolysaccharidoses 0.9652919559003664 2.1052644049168925 0.0352682987371175 1.0 0.1826581079279256 4 P54802,P16278,P15586 3 +Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 0.7500724465608596 2.1039478643315666 0.0353829950881787 1.0 0.1826581079279256 14 Q99519,P16278 2 +Tryptophan catabolism 0.8514891880864996 2.099578790991114 0.0357659100903315 1.0 0.1826581079279256 2 P08195 1 +Cd28 dependent pi3k akt signaling 0.8510811913504713 2.097816319833804 0.0359213743001767 1.0 0.1826581079279256 2 P31751 1 +Synthesis of substrates in n glycan biosythesis 0.7603689882136763 2.090492650881765 0.0365735678760661 1.0 0.1839949419412986 13 Q99519,P16278 2 +Amino acid transport across the plasma membrane 0.9558837636311904 2.081848356012594 0.0373563232525964 1.0 0.1863571125896571 3 Q9H2J7 1 +Sialic acid metabolism 0.9492976815624994 2.0629188609175837 0.0391203378274847 1.0 0.1915296837130012 5 Q99519,P16278 2 +Chondroitin sulfate dermatan sulfate metabolism 0.9497959183673464 2.058901926547481 0.0395036345038768 1.0 0.1919789174967003 3 P06865,P07686 2 +Diseases associated with glycosaminoglycan metabolism 0.9497959183673464 2.058901926547481 0.0395036345038768 1.0 0.1919789174967003 3 P06865,P07686 2 +Hyaluronan metabolism 0.9466326366024718 2.0364290058251804 0.041707295273476 1.0 0.1997400286369744 4 P06865,P07686 2 +Hyaluronan uptake and degradation 0.9466326366024718 2.0364290058251804 0.041707295273476 1.0 0.1997400286369744 4 P06865,P07686 2 +Eph ephrin mediated repulsion of cells 0.843420826459577 2.027037547053836 0.0426585729493176 1.0 0.2028207240947701 8 Q15375 1 +Toll like receptor cascades 0.6938171154228359 2.02065698039691 0.0433152860325665 1.0 0.2030115007291462 17 P05067 1 +Rac3 gtpase cycle 0.6243282267745046 2.015076437642135 0.043896640647939 1.0 0.2050022629490246 24 Q13177,O96013,Q14126,Q9UQB8,P02786,Q9Y2U8,P50402,Q6IAA8,P05556,Q14739 10 +Rac2 gtpase cycle 0.6156568402270547 2.011908301480246 0.0442296041551104 1.0 0.2051070023671847 27 Q13177,Q14126,P02786,Q9Y2U8,P50402,Q6IAA8,Q9UH62,P05556,Q14739 9 +Extracellular matrix organization 0.6186043094250545 1.981914173733005 0.047488847310356 1.0 0.2138221153381865 24 P05067,Q9Y624,Q92542,P20810,O60568,P35613,P05556,O15460 8 +Pink1 prkn mediated mitophagy 0.7830025061498258 1.9807839528421165 0.0476155071568391 1.0 0.2138221153381865 9 Q13501,Q8IWA4,O96008,Q8N4H5 4 +Vesicle mediated transport 0.4544964601711099 1.978425852921977 0.0478806856061606 1.0 0.2138221153381865 182 P05067,Q10472,Q9H3P7,Q4KMP7,Q9UIQ6,P02786,Q8NC96,P31751,O75976,Q9BVK6,P11717,Q14108,P15586,Q8WTV0,Q7Z392,Q9UID3,Q9NVZ3,Q99523,O00461,Q9BUF5,Q10471,P24390,Q99747,P27348,P61163,P51809,Q12907,Q9NSK0,P11233,O95721,Q9Y3E7 31 +O linked glycosylation 0.9277551020408156 1.9754282823489304 0.0482195658735318 1.0 0.2138221153381865 3 Q10472,O43505 2 +O linked glycosylation of mucins 0.9277551020408156 1.9754282823489304 0.0482195658735318 1.0 0.2138221153381865 3 Q10472,O43505 2 +Integrin cell surface interactions 0.9236734693877544 1.9599033602562863 0.0500070868020126 1.0 0.2180772626432139 3 Q9Y624,P35613 2 +Aryl hydrocarbon receptor signalling 0.9210988223722046 1.9500999010501672 0.0511642130555785 1.0 0.2216554887967002 3 Q15185 1 +Lysosome vesicle biogenesis 0.7591399339177225 1.929326274634186 0.0536903698839092 1.0 0.2310791409709429 10 P05067 1 +Vitamin d calciferol metabolism 0.9098842878773856 1.9073049569085083 0.0564811086910903 1.0 0.2391820583478006 3 Q99538 1 +Rac1 gtpase cycle 0.5840577361942162 1.8791589925162029 0.0602227870660869 1.0 0.2525904795096705 30 Q13177,Q9Y2I1,O96013,Q9UQB8,P02786,Q9Y2U8,P50402,Q6IAA8,P05556,Q14739 10 +Membrane trafficking 0.4433188938964474 1.844319643214736 0.0651365704217994 1.0 0.2699564487750818 176 P05067,Q10472,Q9H3P7,Q4KMP7,Q9UIQ6,P02786,Q8NC96,P31751,O75976,Q9BVK6,P11717,Q14108,P15586,Q7Z392,Q9UID3,Q9NVZ3,Q99523,O00461,Q9BUF5,Q10471,P24390,Q99747,P27348,P61163,P51809,Q12907,Q9NSK0,P11233,O95721,Q9Y3E7 30 +Clathrin mediated endocytosis 0.5357678828599358 1.8339658247971509 0.0666590673026474 1.0 0.2726397255825675 39 Q14108,P11717,Q8NC96,P02786 4 +Insulin receptor recycling 0.745847791030447 1.82682709518901 0.0677257706110441 1.0 0.2744456612146003 9 Q93050,Q15904,Q9Y487 3 +Signaling by insulin receptor 0.7235695206199422 1.8254327748471764 0.0679357471766364 1.0 0.2744520829191109 11 Q93050,P31751,Q15904,Q9Y487 4 +Cell surface interactions at the vascular wall 0.7318809555171891 1.8137496954064671 0.0697162703734366 1.0 0.2776684557205241 10 P05026,P08195,Q9Y624,Q92896,P35613,P05556 6 +Irs mediated signalling 0.7796817625459047 1.78538480182717 0.0741989221290215 1.0 0.2861215091665768 2 P31751 1 +Insulin receptor signalling cascade 0.7796817625459047 1.78538480182717 0.0741989221290215 1.0 0.2861215091665768 2 P31751 1 +Fceri mediated ca 2 mobilization 0.7796817625459025 1.7853848018271592 0.0741989221290233 1.0 0.2861215091665768 2 O43865 1 +Antigen activates b cell receptor bcr leading to generation of second messengers 0.7796817625459025 1.7853848018271592 0.0741989221290233 1.0 0.2861215091665768 2 O43865 1 +P75ntr negatively regulates cell cycle via sc1 0.7768257853937219 1.7727359328011207 0.0762724739474052 1.0 0.2907006051161517 2 Q13547 1 +Gpcr ligand binding 0.7779344266528601 1.7680343306952395 0.0770551645379522 1.0 0.2917844775855253 8 P05067 1 +Endosomal vacuolar pathway 0.8708648709787487 1.7524979592372234 0.0796882204702527 1.0 0.2998553895980652 4 P10321,Q9UIQ6 2 +Interleukin 1 signaling 0.5140742435006114 1.746530904717124 0.0807187417347694 1.0 0.3020073376837823 44 Q13501,P05067,P49721,P28072 4 +Sumoylation of dna methylation proteins 0.7686658506732016 1.7365402922187594 0.082468346446771 1.0 0.3025370815331405 2 Q8IXK0 1 +Selective autophagy 0.5739745234374097 1.7307472215070558 0.0834968589762252 1.0 0.3046131946584174 25 Q13501,P67870,Q9BUF5,Q8IWA4,O96008,Q9NS69,Q8N4H5 7 +Signaling by notch3 0.8633274275059692 1.7281179982760662 0.0839670713147842 1.0 0.3054824113855546 3 Q92542 1 +Regulation of beta cell development 0.8587515745108246 1.7103846988623417 0.0871947585963108 1.0 0.3119558934915238 3 P31751 1 +Metabolism of steroids 0.5404306678728701 1.6950159164165286 0.0900724014557816 1.0 0.3163342739127052 34 Q9UBM7,Q99538,Q14849,Q15392,P04062 5 +Synthesis of pc 0.8491238632776557 1.6730095255706448 0.0943254208370683 1.0 0.3197499463796453 3 P35790 1 +Intra golgi and retrograde golgi to er traffic 0.4635681092773486 1.6728742215989965 0.0943520595433544 1.0 0.3197499463796453 66 Q10472,P40616,Q9BVK6,P11717,Q9UID3,P49755,O00461,Q9BUF5,Q10471,P24390,Q9UJW0,Q9BW19,Q99747,P48444,P61163,Q14203,Q6NUQ1,Q9NSK0,O95721,Q9Y678,P35606 21 +Class a 1 rhodopsin like receptors 0.7998082728182723 1.6699484721811548 0.0949295588720131 1.0 0.3197499463796453 7 P05067 1 +Peptide ligand binding receptors 0.7998082728182723 1.6699484721811548 0.0949295588720131 1.0 0.3197499463796453 7 P05067 1 +Stimuli sensing channels 0.8444272675273816 1.659259758651045 0.0970634604296938 1.0 0.3261035137395581 6 Q9C0H2 1 +Immunoregulatory interactions between a lymphoid and a non lymphoid cell 0.8394076741645097 1.6555469595637844 0.0978135990717121 1.0 0.3277875571945163 5 P10321,Q92692,P05556 3 +Rhoc gtpase cycle 0.5614102220426981 1.6440681731379134 0.1001621212516854 1.0 0.3322758531195711 24 O75955,Q9UDY2,Q12802,Q07021,Q9NQW6,P02786,P28288,Q9H2G2,Q14739 9 +Translocation of slc2a4 glut4 to the plasma membrane 0.5564406423514573 1.636742247059933 0.1016843375683136 1.0 0.3339607794949353 26 P68371,P35579,Q9UPT5,Q9UIQ6,P61981,P11233,Q9BUF5,P31751,O60343,P27348 10 +Activation of rac1 0.8390807686877467 1.6315220870035134 0.1027802032610054 1.0 0.335884684106065 4 O94813,Q13177 2 +Cd209 dc sign signaling 0.7417380660954751 1.6165597106334637 0.1059733545992616 1.0 0.3437608571606589 2 Q13177 1 +Runx1 regulates expression of components of tight junctions 0.7384740922072635 1.6019671575851897 0.1091628722075155 1.0 0.3470111206628336 2 Q16625 1 +Ctla4 inhibitory signaling 0.8275658536063615 1.5890324817840085 0.1120530595839928 1.0 0.3538487431827007 3 Q14738 1 +Diseases of dna repair 0.6884619534749946 1.5843738669213054 0.1131086652594448 1.0 0.3546078711876552 9 Q9UQ84,P54132 2 +Rnd1 gtpase cycle 0.6586362877051556 1.5821063196744112 0.1136253011702281 1.0 0.3546078711876552 12 P02786 1 +Translation of replicase and assembly of the replication transcription complex 0.731538147694826 1.570927448188845 0.1161995020840787 1.0 0.3577762581421499 2 Q9Y3E7 1 +Cdc42 gtpase cycle 0.5634492803005786 1.5706219324427515 0.1162704923954747 1.0 0.3577762581421499 22 Q13177,Q9UQB8,P02786,A4D1P6,Q6IAA8,Q14739,Q658P3 7 +Dap12 interactions 0.820919981097298 1.561996658023156 0.1182887761571862 1.0 0.3622937632535216 4 P10321 1 +Cytosolic sulfonation of small molecules 0.7262341901264862 1.5471653030038257 0.1218233903054688 1.0 0.3679393169856813 2 Q8TB61 1 +Transport and synthesis of paps 0.7262341901264862 1.5471653030038257 0.1218233903054688 1.0 0.3679393169856813 2 Q8TB61 1 +Tyrosine catabolism 0.7258261933904564 1.545336580807595 0.1222648715783043 1.0 0.3679393169856813 2 P16930 1 +Transport of bile salts and organic acids metal ions and amine compounds 0.8160623473117283 1.5440785015484548 0.1225693162852401 1.0 0.3679393169856813 3 Q9H2J7 1 +Retrograde transport at the trans golgi network 0.6570619604879634 1.5323065878901254 0.125446796191134 1.0 0.3723054944034548 11 Q99747,Q9UID3,P11717,P40616 4 +Cell death signalling via nrage nrif and nade 0.7186826346321518 1.528267143313619 0.1264462241703441 1.0 0.3725496134951749 8 Q13501,Q92542 2 +Interleukin 1 family signaling 0.484157219072017 1.5243977336545516 0.1274093859103442 1.0 0.3745494670623289 45 Q13501,P05067,P49721,P28072 4 +Amyloid fiber formation 0.7890610148286984 1.464738590394309 0.1429922519755662 1.0 0.4041218795103448 5 P05067 1 +Downregulation of erbb2 erbb3 signaling 0.703794369645051 1.446435046174884 0.1480552180131455 1.0 0.4100886997681422 2 P31751 1 +Synaptic adhesion like molecules 0.7806054465337128 1.432517115142651 0.1519958835144415 1.0 0.4175501302378025 5 Q15334,O75955 2 +Rhoq gtpase cycle 0.606791220249124 1.4318656313982925 0.1521822798133221 1.0 0.4175501302378025 14 Q658P3,Q13177,P02786,Q6IAA8 4 +Fcgamma receptor fcgr dependent phagocytosis 0.5595862737415002 1.4264355568296876 0.1537426562291211 1.0 0.4194825918270304 19 Q9UQB8,Q8IV08 2 +Transport of inorganic cations anions and amino acids oligopeptides 0.7370533380529285 1.4259046727068136 0.1538958604539981 1.0 0.4194825918270304 7 Q9H2J7,P08195 2 +Bmal1 clock npas2 activates circadian gene expression 0.6984904120767028 1.422591771263725 0.1548545308037887 1.0 0.4196366606349583 2 P43490 1 +Notch hlh transcription pathway 0.7771428571428556 1.3914552157550326 0.1640874309837627 1.0 0.4401286081580765 3 Q13547,Q13573 2 +Constitutive signaling by aberrant pi3k in cancer 0.7743657864096294 1.3805442129998189 0.1674191464250771 1.0 0.4472434398414333 3 P84095 1 +Fceri mediated mapk activation 0.7725128868422977 1.3732634414457088 0.1696704634528889 1.0 0.4514262633685954 3 Q13177 1 +Tp53 regulates transcription of cell death genes 0.7684739548530295 1.3600494310975737 0.1738142819698538 1.0 0.460590360873838 4 Q658P3 1 +Basigin interactions 0.7619604909815593 1.3522857465225455 0.1762839223089485 1.0 0.462481923667102 6 P08195,P35613,P05026,P05556 4 +Resolution of d loop structures 0.7576830573880381 1.3362515278977516 0.1814670740255815 1.0 0.4673985200868195 6 Q9UQ84,P54132 2 +Resolution of d loop structures through synthesis dependent strand annealing sdsa 0.7576830573880381 1.3362515278977516 0.1814670740255815 1.0 0.4673985200868195 6 Q9UQ84,P54132 2 +Interferon gamma signaling 0.6269898575362534 1.3195703070558464 0.1869785220139503 1.0 0.4753874777845032 9 P10321,Q12899 2 +Cd28 co stimulation 0.7495375767611838 1.305702221061554 0.1916538423850902 1.0 0.4811458586196833 6 Q13177,P31751,P42345 3 +Rhoj gtpase cycle 0.5800149232516663 1.3019827456486666 0.1929222840105784 1.0 0.4811458586196833 14 Q658P3,Q13177,P02786,Q6IAA8 4 +Defective intrinsic pathway for apoptosis 0.5886375646170527 1.2999228442832256 0.1936274146305483 1.0 0.4811458586196833 13 P05067 1 +Reduction of cytosolic ca levels 0.7506169922334871 1.29107753174323 0.196676794206742 1.0 0.4868859736283443 4 P30626,P20020 2 +Platelet calcium homeostasis 0.7506169922334871 1.29107753174323 0.196676794206742 1.0 0.4868859736283443 4 P30626,P20020 2 +Negative regulation of the pi3k akt network 0.7436947602766746 1.2837793576782444 0.1992191682193189 1.0 0.4922544925794428 6 Q14738,P84095,P31751 3 +Signal transduction by l1 0.7481684850277457 1.2816191088068634 0.1999762935663285 1.0 0.4922780908913171 4 P67870 1 +Antigen processing cross presentation 0.4492303538901649 1.2715857668618595 0.2035203364673121 1.0 0.4970109987289584 48 P60900,P49721,Q9UIQ6,P10321,P01889,P28072 6 +Intra golgi traffic 0.6947218929697194 1.2596261826853634 0.2078042457304403 1.0 0.5011393641616317 7 Q99747,O00461 2 +Slc mediated transmembrane transport 0.5521841168816307 1.2589120868841923 0.2080620875801992 1.0 0.5011393641616317 16 P55011,P08195,Q9H2J7,P35613 4 +Costimulation by the cd28 family 0.6127288868148325 1.2576380621853065 0.2085226815190388 1.0 0.5011393641616317 9 Q14738,Q13177,P31751,P42345 4 +Autophagy 0.4712711888615632 1.2405801989614489 0.2147608705029349 1.0 0.5123914247325457 35 Q13501,Q5MNZ6,P67870,Q9Y3E7,Q9BUF5,Q8IWA4,O96008,Q96HS1,Q6IAA8,Q9NS69,Q8N4H5 11 +Rhob gtpase cycle 0.557630344861826 1.2375429906398052 0.2158855642946862 1.0 0.5141433782569651 15 Q14254,Q9UDY2,O75955,Q12802,Q16513,Q9NQW6,P02786,Q9H2G2,O75116 9 +P75 ntr receptor mediated signalling 0.5665292067219597 1.2362636132542872 0.216360591755842 1.0 0.5143445836506207 14 Q13501,Q92542,Q12802 3 +Regulation of localization of foxo transcription factors 0.7241710082365626 1.2105008958376944 0.2260867472242442 1.0 0.5284582605619521 6 P31751,P27348,P61981 3 +Leishmania infection 0.488091926187299 1.2099185629560976 0.2263101434752779 1.0 0.5284582605619521 26 P05067 1 +Regulated necrosis 0.5576491985406107 1.1929129162437062 0.2329034801794889 1.0 0.5390753662502407 14 P09429,Q9Y3E7,O75955,Q13546 4 +G alpha i signalling events 0.5217415203636655 1.1751303946741898 0.2399425521765574 1.0 0.5448632522640785 18 P05067,Q9ULM6 2 +Signaling by fgfr1 0.6434108527131821 1.1750993691453873 0.2399549630320163 1.0 0.5448632522640785 2 P62993 1 +Signaling by fgfr4 0.6434108527131821 1.1750993691453873 0.2399549630320163 1.0 0.5448632522640785 2 P62993 1 +Negative regulation of fgfr3 signaling 0.6434108527131821 1.1750993691453873 0.2399549630320163 1.0 0.5448632522640785 2 P62993 1 +Negative regulation of fgfr1 signaling 0.6434108527131821 1.1750993691453873 0.2399549630320163 1.0 0.5448632522640785 2 P62993 1 +Signaling by fgfr3 0.6434108527131821 1.1750993691453873 0.2399549630320163 1.0 0.5448632522640785 2 P62993 1 +Spry regulation of fgf signaling 0.6434108527131821 1.1750993691453873 0.2399549630320163 1.0 0.5448632522640785 2 P62993 1 +Negative regulation of fgfr2 signaling 0.6434108527131821 1.1750993691453873 0.2399549630320163 1.0 0.5448632522640785 2 P62993 1 +Negative regulation of fgfr4 signaling 0.6434108527131821 1.1750993691453873 0.2399549630320163 1.0 0.5448632522640785 2 P62993 1 +Platelet homeostasis 0.7090943068182012 1.1539382871714388 0.2485254707909328 1.0 0.5550129701427986 6 Q14738,P20020,P30626 3 +Protein protein interactions at synapses 0.5789769280153582 1.144351143929864 0.2524780409538372 1.0 0.5588463528339557 10 Q15334,Q14254,O75955,Q96HC4 4 +Activation of bh3 only proteins 0.5783507175772333 1.141567662038156 0.2536337722157795 1.0 0.5604625469935933 10 Q9Y3B8,P31751,P27348,P61981 4 +Signaling by notch1 pest domain mutants in cancer 0.6624018114803002 1.132416003453803 0.2574595798224859 1.0 0.5656454515250204 7 Q92542,Q13573 2 +Signaling by notch1 0.6223812054061385 1.1315220020831926 0.2578354482116904 1.0 0.5656454515250204 8 Q13547,Q96J02,Q92542,Q13573 4 +Cd28 dependent vav1 pathway 0.7081155184715742 1.127119406865662 0.2596919991501933 1.0 0.5681301708983466 4 Q13177 1 +Signaling by type 1 insulin like growth factor 1 receptor igf1r 0.7089795918367321 1.1239276562461626 0.2610437175886784 1.0 0.5701402588130837 3 P31751,P62993 2 +Rhog gtpase cycle 0.467006168598017 1.1172857134028271 0.2638721820296066 1.0 0.5743602911143691 30 Q13177,Q14126,P02786,Q9Y2U8,P84095,P50402,Q6IAA8,P05556,Q14739 9 +Downregulation of erbb2 signaling 0.6990568122578804 1.116322218870639 0.2642842341801881 1.0 0.5743602911143691 6 Q93034 1 +Activation of bad and translocation to mitochondria 0.6164834112812896 1.107148019949322 0.2682299368936447 1.0 0.5800637551542366 8 P31751,P27348,P61981 3 +Methionine salvage pathway 0.7019124820254938 1.1032701906741322 0.2699098477575661 1.0 0.5817860384561613 4 Q13126 1 +Rhoa gtpase cycle 0.4509054659932376 1.0955457054372248 0.2732776333449322 1.0 0.5871233982304662 35 Q15904,O75955,Q12802,Q9UDY2,Q07021,Q96CS3,Q9NQW6,P02786,P28288,Q9H2G2,Q14739,P30519 12 +Mhc class ii antigen presentation 0.4302104799424325 1.088060095252016 0.2765685786317262 1.0 0.5871527196268513 43 P10619,Q99538,Q9NSK0,Q9BUF5 4 +Glycerophospholipid biosynthesis 0.5056420230909109 1.0880220602982027 0.276585368867744 1.0 0.5871527196268513 18 P35790,Q8IV08 2 +Hemostasis 0.3836513768203151 1.06669057901942 0.2861115827055678 1.0 0.5990766145528227 92 P05067,Q14738,Q08380,Q9H4M9,O15439,Q06481,Q13547,P05026,Q9BUF5,P54709,Q8IWA4,Q92896,P05556,O43852,Q9Y624,Q9NSK0,Q07021,P08195,P42785,P84095,P35613 21 +Ros and rns production in phagocytes 0.6012745663998889 1.0443751406228592 0.2963118604541399 1.0 0.6126259344083238 8 Q93050,Q9Y487 2 +Rhoh gtpase cycle 0.5021258682997802 1.0330456020135432 0.3015825584613325 1.0 0.619747562961597 17 Q13177,Q9BZH6,P02786,Q6IAA8 4 +Rho gtpases activate ktn1 0.5963659972982689 1.0241513777291738 0.305763780347779 1.0 0.6243269747566279 8 Q9NSK0 1 +Death receptor signalling 0.4999353993714289 1.0214827588060136 0.3070257735338897 1.0 0.6259333494491219 17 Q13501,Q92542,Q12802 3 +Sphingolipid de novo biosynthesis 0.5942510345616491 1.0154444121527428 0.3098940316234408 1.0 0.6308043889460149 8 O15269 1 +Rho gtpases activate paks 0.5533733797200457 0.999596196738604 0.3175059644533977 1.0 0.6413425693023387 9 Q13177,Q14247,P35579 3 +Dna damage reversal 0.6030191758465964 0.9954150852144652 0.3195344247240415 1.0 0.6444515120391464 2 Q6P6C2 1 +Pyroptosis 0.6688444262964377 0.9768405396198608 0.3286481025875338 1.0 0.6598011449813751 4 P09429,Q9Y3E7,Q8WUX9 3 +Fcgr3a mediated il10 synthesis 0.6647721271054721 0.961379943579992 0.3363611649895317 1.0 0.6663395928957575 4 O43865 1 +Diseases of programmed cell death 0.4673455199538709 0.9554829418781692 0.3393335276638516 1.0 0.6680153302440845 20 P05067 1 +Hdms demethylate histones 0.6550171919580784 0.9539364422019012 0.3401158154793091 1.0 0.6685560134123136 5 Q8NB78 1 +Response of eif2ak1 hri to heme deficiency 0.6583803672399746 0.9279159651186684 0.3534511622275811 1.0 0.6845517362554769 3 P20042 1 +Regulation of glycolysis by fructose 2 6 bisphosphate metabolism 0.6574913347746272 0.9245134034036692 0.3552190762826304 1.0 0.6864022072353549 3 Q14738 1 +Cell cell junction organization 0.6091489939076333 0.9240717144345832 0.3554489789935551 1.0 0.6864022072353549 7 Q9Y624 1 +Eph ephrin signaling 0.4485232790816377 0.9200789106138356 0.3575315242007528 1.0 0.6881153516260431 23 Q15375,Q92542 2 +Signaling by erbb4 0.6076785177977274 0.9183683251299488 0.3584260677414317 1.0 0.6881153516260431 7 Q92542 1 +Hdr through single strand annealing ssa 0.5133051026138619 0.9103373266639296 0.3626446390734785 1.0 0.694190391947342 12 Q9UQ84,P54132 2 +Synthesis of active ubiquitin roles of e1 and e2 enzymes 0.5313735687516143 0.904595509323432 0.3656797152546094 1.0 0.6987975706640616 9 P49427 1 +Adaptive immune system 0.3648108429447423 0.9024470337068756 0.3668194457684659 1.0 0.6987975706640616 153 Q14738,Q9UIQ6,Q92692,Q99538,Q8TBC4,P55786,P60900,P10619,Q9BUF5,Q16763,P05556,P49721,P10321,P61163,P01889,Q03519,P28072,Q9NSK0,P49427,Q93034,Q7Z6Z7 21 +Copi independent golgi to er retrograde traffic 0.4491957012053312 0.8970020043048563 0.3697178475149481 1.0 0.6987975706640616 22 Q10472,P61163,Q14203,Q9BUF5,Q10471,Q9UJW0 6 +Ion homeostasis 0.509489868372925 0.8927471301007875 0.3719926050049202 1.0 0.6987975706640616 12 P30626,P05026,P54709,O43865,P17612,P23634,P20020 7 +Cardiac conduction 0.509489868372925 0.8927471301007875 0.3719926050049202 1.0 0.6987975706640616 12 P30626,P05026,P54709,O43865,P17612,P23634,P20020 7 +Gap junction assembly 0.6485009910936244 0.8902121297474309 0.3733519927399427 1.0 0.6987975706640616 3 Q9BUF5 1 +Transport of connexons to the plasma membrane 0.6485009910936244 0.8902121297474309 0.3733519927399427 1.0 0.6987975706640616 3 Q9BUF5 1 +Activation of ampk downstream of nmdars 0.6485009910936244 0.8902121297474309 0.3733519927399427 1.0 0.6987975706640616 3 Q9BUF5 1 +Platelet activation signaling and aggregation 0.4130632368584504 0.8898601302311517 0.3735409944931658 1.0 0.6987975706640616 38 P05067,Q08380,Q06481 3 +Ion transport by p type atpases 0.5203327804824983 0.8847145497590582 0.3763106063494827 1.0 0.7003830529191793 10 P30626,Q9HD20,P05026,P54709,P20020 5 +Rnd3 gtpase cycle 0.4866628182214282 0.8820484856845352 0.3777505880201492 1.0 0.7003830529191793 15 Q9NYL9,Q14254,Q9Y2I1,O43396,Q9Y2U8,O75976 6 +Ripk1 mediated regulated necrosis 0.5189127773779578 0.8784828867193974 0.3796817207576202 1.0 0.7009283455191953 10 O75955,Q13546 2 +Homologous dna pairing and strand exchange 0.4991219157222838 0.8743316465945642 0.3819376698031411 1.0 0.703513162420611 13 Q9UQ84,P54132 2 +Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex 0.5581545938877641 0.8677850852067218 0.3855119964610694 1.0 0.7081161776000395 8 P27348,P61981 2 +Notch1 intracellular domain regulates transcription 0.6309036946997305 0.8637458089746182 0.3877275429564881 1.0 0.7102046927311473 5 Q13547,Q92769,Q13573 3 +Maturation of sars cov 2 nucleoprotein 0.6299902893988537 0.8600740118519474 0.3897482457682231 1.0 0.7119257138373783 6 P48729,Q99873 2 +Rnd2 gtpase cycle 0.4780718873747089 0.8393685008949546 0.401262554156107 1.0 0.7261094565159071 15 Q9Y2U8,O43396,P02786 3 +Cell junction organization 0.4780323312331601 0.839172392055306 0.4013725773299774 1.0 0.7261094565159071 15 Q9Y624,Q92692 2 +Mitochondrial protein import 0.4214507077239925 0.837189383773622 0.4024861238934463 1.0 0.7271251374042096 32 Q99595,O14925,O96008,O60830,Q8N4H5 5 +Dcc mediated attractive signaling 0.5646674826601435 0.8286155356660241 0.4073219941711723 1.0 0.7294634926395304 2 P60953 1 +Phosphorylation of emi1 0.5638514891880915 0.8251266483999692 0.4092996919613125 1.0 0.7294634926395304 2 P06493 1 +Signaling by notch4 0.3967999173279871 0.8190263764417456 0.412771364932528 1.0 0.733630077754574 40 P28072,P49721,Q92542 3 +Ire1alpha activates chaperones 0.439316797853644 0.8161223135604108 0.4144301830578856 1.0 0.7355856483655462 21 Q13217,P61421,O14773,Q9NWM8 4 +Signaling by tgfb family members 0.4690072306471198 0.7945412337100886 0.4268804142502054 1.0 0.7476083850631923 15 Q13547,Q9Y624,Q13573 3 +Sealing of the nuclear envelope ne by escrt iii 0.6115878674222227 0.7932001951723152 0.4276611938324584 1.0 0.747750780879214 6 P68371,Q9Y3E7,Q9BUF5 3 +Interleukin 3 interleukin 5 and gm csf signaling 0.6160984402963757 0.7794980557477744 0.4356863824394787 1.0 0.7565516886268692 4 P62993 1 +Cholesterol biosynthesis 0.4846329878350934 0.7789517318295746 0.436008148570838 1.0 0.7565516886268692 12 Q15392,Q9UBM7 2 +Antigen processing ubiquitination proteasome degradation 0.3621830627835462 0.7634709464142889 0.4451825829164977 1.0 0.7654118298969027 80 P55786,P49721,P60900,Q9UIQ6,P49427,Q8TBC4,Q93034,Q16763,P28072 9 +Rho gtpase cycle 0.3425207457545949 0.7567091492561974 0.4492241322183314 1.0 0.7668513395471808 128 Q5JTV8,Q13177,O96013,P02786,O43396,P28288,O75976,Q96AC1,Q658P3,Q9NYL9,Q15904,O75955,Q9NQW6,Q6IAA8,P05556,P30519,Q12802,Q14126,Q9UQB8,Q9Y2U8,Q14739,Q9BZH6,Q9UDY2,Q07021,Q9Y2I1,A4D1P6,P84095,P50402,Q9UH62,Q96CS3 30 +Degradation of the extracellular matrix 0.5652072215786408 0.7557137551839147 0.4498208351936124 1.0 0.7668513395471808 7 Q92542 1 +Interconversion of nucleotide di and triphosphates 0.4596376400448136 0.7484804101952359 0.4541704368722061 1.0 0.7717967294976716 15 Q9Y3D8,P04818,P15531,Q16881,P17812,P23919,Q9NRF8,P33316,P00568 9 +Clec7a dectin 1 signaling 0.3862828335014267 0.7426111498675642 0.4577171360850451 1.0 0.7742146331631242 43 P28072,P49721,P49427,Q8TBC4 4 +Interferon alpha beta signaling 0.5232381799915181 0.7277517630988763 0.4667655574171734 1.0 0.7820995408631265 8 P10321 1 +Metabolism of cofactors 0.6004987097248595 0.7227335051757422 0.4698436267393715 1.0 0.7852589548423252 4 O75874 1 +Phospholipid metabolism 0.4093896434475977 0.7124612016064431 0.4761792287181219 1.0 0.7911503404805158 26 P35790,Q8IV08 2 +Pka activation in glucagon signalling 0.5980624275727464 0.7024806887498315 0.4823794407030024 1.0 0.7911503404805158 3 P17612 1 +Pka mediated phosphorylation of creb 0.5980624275727464 0.7024806887498315 0.4823794407030024 1.0 0.7911503404805158 3 P17612 1 +Creb1 phosphorylation through the activation of adenylate cyclase 0.5980624275727464 0.7024806887498315 0.4823794407030024 1.0 0.7911503404805158 3 P17612 1 +Glucagon signaling in metabolic regulation 0.5980624275727464 0.7024806887498315 0.4823794407030024 1.0 0.7911503404805158 3 P17612 1 +Vasopressin regulates renal water homeostasis via aquaporins 0.5980624275727464 0.7024806887498315 0.4823794407030024 1.0 0.7911503404805158 3 P17612 1 +Aquaporin mediated transport 0.5980624275727464 0.7024806887498315 0.4823794407030024 1.0 0.7911503404805158 3 P17612 1 +Cell cell communication 0.4156721624484004 0.6809238263961561 0.49591969091643 1.0 0.8023880595202925 21 P62993,Q92692,Q9Y5K6,Q9Y624,Q96AC1,P05556 6 +Uch proteinases 0.3758752092661932 0.6635878966356096 0.5069541059162912 1.0 0.8153897048762977 44 P28072,Q8NB78,P49721 3 +Signaling by tgf beta receptor complex 0.4453119513623891 0.650119480372544 0.5156150468930236 1.0 0.8215292121788241 14 Q9Y624,Q13573 2 +Disassembly of the destruction complex and recruitment of axin to the membrane 0.5696472657848175 0.6421097861290016 0.5208019023004065 1.0 0.8215292121788241 5 Q14738 1 +Beta catenin phosphorylation cascade 0.5696472657848175 0.6421097861290016 0.5208019023004065 1.0 0.8215292121788241 5 Q14738 1 +Signaling by ctnnb1 phospho site mutants 0.5696472657848175 0.6421097861290016 0.5208019023004065 1.0 0.8215292121788241 5 Q14738 1 +Rho gtpases activate cit 0.4675341019609638 0.6360350166115959 0.5247535989554404 1.0 0.8237192965724851 9 Q15334,P35579,O43663 3 +Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand 0.3961075849073061 0.6301541714161376 0.5285937200215391 1.0 0.8274373194029568 26 Q15185,P61163,Q14203,Q9BUF5,O60884,P68371,Q9UJW0,Q13409,P25685,P63167 10 +Cell extracellular matrix interactions 0.5644720917689279 0.626871556958556 0.5307434330565077 1.0 0.8291685662341882 6 Q96AC1,P05556 2 +Neurexins and neuroligins 0.5614538727297671 0.616524348311504 0.5375485071612707 1.0 0.8378122886762053 6 Q15334 1 +Signaling by erbb2 0.4622928536010144 0.6147493313280656 0.5387202757216518 1.0 0.8386461029851247 9 Q93034,P31751,P62993,P40818 4 +C type lectin receptors clrs 0.3682107905379717 0.6060657535096743 0.5444710909697132 1.0 0.8433735633149262 45 P28072,P49721,P49427,Q8TBC4 4 +Golgi to er retrograde transport 0.3618684593412153 0.6018582944416468 0.54726846752742 1.0 0.8433735633149262 55 Q10472,Q9BVK6,P49755,Q9BUF5,Q10471,P24390,Q9UJW0,Q9BW19,Q99747,P48444,P61163,Q14203,Q6NUQ1,O95239,P63167,P61923,Q9NSK0,Q9Y678,P35606,P68371,Q02241 21 +Unfolded protein response upr 0.382842487936332 0.5995575093547928 0.5488011721798722 1.0 0.8433735633149262 34 P61421,Q9NQT5,Q14203,O14773,Q9NWM8,Q13217,Q9Y2L1,Q15024,O94979,Q9Y3B2 10 +Regulation of tp53 activity through phosphorylation 0.4007220208937532 0.5969118756658509 0.5505662180927038 1.0 0.8441013320585019 21 Q9UQ84,P67870,P54132,P38398 4 +Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation 0.5659073318495962 0.5886706502216773 0.5560822300241357 1.0 0.846935389651883 3 P00374 1 +Signaling by interleukins 0.3355770245783689 0.5672301175969046 0.5705578484557803 1.0 0.8540931160231309 95 Q13501,P05067,Q13126,P49721,P60900,P11233,P28072,O00170,O14979,P05556 10 +Metalloprotease dubs 0.5560316546028055 0.5669773258806637 0.5707295866556799 1.0 0.8540931160231309 4 P38398 1 +Class i mhc mediated antigen processing presentation 0.3310367979457791 0.5659018183266878 0.5714605254244367 1.0 0.8540931160231309 100 P55786,P49721,P60900,Q9UIQ6,P10321,P49427,P01889,Q8TBC4,Q93034,Q03519,Q16763,P28072 12 +Sars cov 1 infection 0.43932621935069 0.5597351493767926 0.5756601034727769 1.0 0.8557564836641043 11 Q10472 1 +Hdr through homologous recombination hrr 0.4007987462651214 0.5555418198473028 0.5785241138093928 1.0 0.8580138039267684 19 Q9UQ84,P35251,P54132,P38398 4 +Post chaperonin tubulin folding pathway 0.5406546040010191 0.5464878341428556 0.5847306481880241 1.0 0.8617063348030182 6 P68371,O75347,Q9BUF5 3 +Regulation of tp53 activity through methylation 0.4953080375356988 0.5461837899148827 0.5849396076794975 1.0 0.8617063348030182 2 P04637 1 +Fceri mediated nf kb activation 0.3607870691045787 0.5452186435439765 0.585603150560825 1.0 0.8617199433392252 40 P28072,P49721,P49427 3 +Sulfur amino acid metabolism 0.443352546340672 0.5392358907927975 0.589724098330747 1.0 0.8658490942046754 9 Q13126 1 +Signaling by hippo 0.533193845139895 0.5182478508631468 0.6042853526867715 1.0 0.8823102100759181 5 Q9UDY2 1 +Processing of dna double strand break ends 0.3786300251390002 0.505910274478412 0.6129196392005676 1.0 0.8882127492203707 23 Q9UQ84,P38398,P54132,Q9UNS1 4 +Activation of nima kinases nek9 nek6 nek7 0.5346938775510158 0.4844113238998487 0.6280939834870467 1.0 0.9020717298281792 3 P06493,P53350 2 +Suppression of phagosomal maturation 0.5182804634994044 0.4739913301189009 0.6355060897564302 1.0 0.905332687775783 6 Q14974,Q9H267,P52294 3 +Regulation of pten stability and activity 0.3534209007968443 0.4710071864464045 0.6376356029658214 1.0 0.905332687775783 39 P28072,P67870,P49721 3 +Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 0.4223601501635701 0.4586091268614516 0.6465148813480854 1.0 0.9116275147060262 9 Q9H9A5,Q9ULM6 2 +Plasma lipoprotein assembly 0.4679722562219503 0.4458389732085483 0.6557135673565189 1.0 0.919674939519207 2 P17612 1 +Ptk6 regulates proteins involved in rna processing 0.4663402692778542 0.4401072991962247 0.6598593955921845 1.0 0.9221916014246846 2 Q07666 1 +Dectin 1 mediated noncanonical nf kb signaling 0.3459532591988221 0.4359933546483931 0.6628415510447025 1.0 0.9221916014246846 40 P28072,P49721,Q8TBC4 3 +Tnfr2 non canonical nf kb pathway 0.3459532591988221 0.4359933546483931 0.6628415510447025 1.0 0.9221916014246846 40 P28072,P49721,Q8TBC4 3 +Semaphorin interactions 0.3879357957159468 0.4344752161042663 0.6639433883569372 1.0 0.9223770490148592 16 P35579,Q13177,P05556,O75116 4 +Carboxyterminal post translational modifications of tubulin 0.5132397919037379 0.4287221528872899 0.6681254371121574 1.0 0.9257658129881698 4 Q9BUF5 1 +Perk regulates gene expression 0.4055493882696147 0.422995540619596 0.6722985146349465 1.0 0.9290840963003404 11 Q9NQT5,P20042,Q9Y2L1,Q15024,Q9Y3B2 5 +Endosomal sorting complex required for transport escrt 0.5091228659148943 0.4161830737394071 0.6772760445105439 1.0 0.9300124682272848 4 Q8WUX9,Q9Y3E7 2 +Transcriptional regulation by e2f6 0.5006289608734862 0.4150804376161578 0.6780830195960248 1.0 0.9300124682272848 5 Q13185,P38398 2 +Signaling by vegf 0.3764402429584792 0.4116766043142673 0.6805764753082761 1.0 0.9300124682272848 18 O43865,Q9UQB8,P31751,P42345 4 +Intrinsic pathway for apoptosis 0.391414352878027 0.4088492081978999 0.6826503252023102 1.0 0.9300124682272848 14 P31751,P27348,Q07021 3 +Rap1 signalling 0.5097959183673421 0.4067911110921197 0.6841614158596787 1.0 0.9300124682272848 3 P63104,P17612 2 +Signaling by wnt in cancer 0.4629207418179922 0.3962403944438581 0.6919276943695045 1.0 0.9300124682272848 7 Q14738 1 +Rho gtpases activate iqgaps 0.4331391276294909 0.394291376070744 0.6933659295619996 1.0 0.9300124682272848 8 Q9BUF5 1 +Protein ubiquitination 0.3605325072054683 0.3913794701359968 0.6955167649966902 1.0 0.9300124682272848 22 P49427,Q14527 2 +Diseases associated with n glycosylation of proteins 0.4508363933088508 0.3872816517774059 0.6985477075211273 1.0 0.9300124682272848 2 O75340 1 +Deactivation of the beta catenin transactivating complex 0.4872293149680959 0.3793508294044574 0.7044273589292942 1.0 0.9300124682272848 6 P31751 1 +E2f enabled inhibition of pre replication complex formation 0.4483884128927067 0.3792218548720974 0.7045231236678222 1.0 0.9300124682272848 2 P06493 1 +Flt3 signaling 0.4956407372162369 0.3652359906543039 0.7149352545956775 1.0 0.9372295595480504 3 P31751 1 +Copi dependent golgi to er retrograde traffic 0.3434776065320875 0.3586841833839368 0.7198313619481116 1.0 0.9414279083273714 36 Q9NSK0,Q9BW19,P49755,Q9Y678,Q9BUF5,Q02241,P24390,P35606,Q6NUQ1,P68371,O95239,Q9BVK6,Q99747,P48444,P61923 15 +Translation of sars cov 2 structural proteins 0.3678837998390782 0.356692736261595 0.7213218439483233 1.0 0.942044456107304 17 Q99873 1 +Sars cov 2 infection 0.3555764924569494 0.355287278324236 0.7223743850282047 1.0 0.942044456107304 21 Q10472,Q9Y3E7,Q99873 3 +Prolactin receptor signaling 0.4406364749081971 0.3542334097143715 0.7231639674445591 1.0 0.942044456107304 2 P63208 1 +Fbxw7 mutants and notch1 in cancer 0.4406364749081971 0.3542334097143715 0.7231639674445591 1.0 0.942044456107304 2 P63208 1 +Kinesins 0.3801486581397119 0.34788418058062 0.7279271661767894 1.0 0.9432692737339036 13 Q9NSK0,Q9BUF5,P68371,O95239,Q9BW19,Q02241 6 +Ksrp khsrp binds and destabilizes mrna 0.3915443586310768 0.3477118355857891 0.7280566071757542 1.0 0.9432692737339036 9 Q9Y2L1,Q15024,Q9Y3B2 3 +Mrna decay by 3 to 5 exoribonuclease 0.3816514890574796 0.3421749867233443 0.7322192080333751 1.0 0.9432692737339036 12 Q9NQT5,Q9Y2L1,Q15024,Q96C86,Q9Y3B2 5 +Tristetraprolin ttp zfp36 binds and destabilizes mrna 0.4171343925459544 0.3418708969415889 0.7324480523174621 1.0 0.9432692737339036 8 Q9Y2L1,Q15024,Q9Y3B2 3 +Intraflagellar transport 0.416891540245649 0.3410965792040028 0.7330308763772893 1.0 0.9432692737339036 8 Q9BW83,P68371,A0AVF1,Q9BUF5 4 +Anchoring of the basal body to the plasma membrane 0.3458425608917454 0.3356676088418372 0.7371215343672732 1.0 0.9452668556589084 25 P61981,Q15019,Q15154,P61163,Q14203,Q7Z460,Q15691,P07437,P68371,P17612,P63167,O94927 12 +Atf4 activates genes in response to endoplasmic reticulum stress 0.3843987026933519 0.3235084103495307 0.7463102391537126 1.0 0.9514913697632522 9 Q9NQT5,Q9Y2L1,Q15024,Q9Y3B2 4 +Butyrate response factor 1 brf1 binds and destabilizes mrna 0.4383590271322634 0.3215650572878117 0.7477822191010861 1.0 0.9524460179459676 7 Q9Y2L1,Q15024,Q9Y3B2 3 +Tcr signaling 0.328769840690661 0.3098889873303587 0.7566453776938324 1.0 0.9587586546322164 43 P28072,P49721,P49427 3 +Tp53 regulates transcription of death receptors and ligands 0.4247246022031832 0.3056176442235293 0.7598957847293344 1.0 0.9587586546322164 2 P04637 1 +Nr1h2 nr1h3 regulate gene expression linked to lipogenesis 0.4247246022031796 0.3056176442235185 0.7598957847293426 1.0 0.9587586546322164 2 O00767 1 +Antigen presentation folding assembly and peptide loading of class i mhc 0.3585871108724431 0.3054107426859072 0.7600533409263348 1.0 0.9587586546322164 16 P04439,P10321,Q6P179,P01889,Q03519 5 +Phosphorylation of the apc c 0.3786787006535645 0.304594508060018 0.7606750033180554 1.0 0.9587586546322164 9 Q16763 1 +Recruitment of mitotic centrosome proteins and complexes 0.3401165079532412 0.3044092907263687 0.7608160904779588 1.0 0.9587586546322164 25 P61981,Q15154,P61163,Q14203,Q7Z460,Q15691,P07437,P68371,P17612,P63167,O94927 11 +Fc epsilon receptor fceri signaling 0.3272433495202826 0.2984832624075517 0.7653343489062983 1.0 0.9598370195639792 44 P28072,P49721,P49427 3 +Cooperation of prefoldin and tric cct in actin and tubulin folding 0.3562126969239911 0.2801299674406077 0.7793777940469957 1.0 0.9710885097066162 15 Q99471,Q9UHV9,Q9BUF5 3 +Tp53 regulates transcription of cell cycle genes 0.3555967387483976 0.2776989097693554 0.7812434975708378 1.0 0.9724930872408254 15 Q9H9A5,Q9ULM6,Q99873 3 +G2 m dna damage checkpoint 0.3353775711544534 0.2733265750156938 0.7846021888930359 1.0 0.9751874777487934 30 Q9UQ84,P54132,P27348,P38398 4 +Rho gtpases activate wasps and waves 0.3567549976081624 0.2522902041602397 0.8008167592474731 1.0 0.9866002543769148 12 Q9UQB8 1 +Aberrant regulation of mitotic exit in cancer due to rb1 defects 0.3858818213621582 0.2480043096741986 0.8041310723168402 1.0 0.9897575908796996 8 Q16763 1 +Recruitment of numa to mitotic centrosomes 0.3294233267228629 0.239924096869886 0.8103890997690602 1.0 0.9937452927335684 28 P61981,Q15154,P61163,Q14203,Q7Z460,Q9BUF5,Q15691,P07437,P68371,P17612,P63167,O94927 12 +Collagen biosynthesis and modifying enzymes 0.3528748157011913 0.2342008669282475 0.8148290420218083 1.0 0.9973325728092208 11 O60568,P13674,O15460 3 +Apc c cdc20 mediated degradation of cyclin b 0.3803676214370223 0.2327450711167051 0.8159593684334199 1.0 0.9977887541567448 8 Q16763 1 +Phenylalanine and tyrosine metabolism 0.4430074359403043 0.2301192329599209 0.8179991201601227 1.0 0.9983610440035248 3 P16930 1 +The phototransduction cascade 0.4419716658888233 0.2277983909201143 0.8198029776719193 1.0 0.9983610440035248 3 P49356 1 +Regulation of bach1 activity 0.4408163265306078 0.2252260002591238 0.8218034637362872 1.0 0.9993676470366484 3 Q13309,P63208 2 +Sema4d in semaphorin signaling 0.4011019866448627 0.2209310912582701 0.825146088200639 1.0 1.0 7 P35579,O75116 2 +Signaling by receptor tyrosine kinases 0.3065803800516128 0.2196270456438613 0.8261616262695717 1.0 1.0 81 Q13547,Q14738,Q15904,P11233,Q9UQB8,Q9Y487,Q93034,P31751,Q92542,Q93050,Q15334,P05556 12 +Regulation of plk1 activity at g2 m transition 0.324536488825431 0.2186937981155082 0.8268885804404837 1.0 1.0 26 P68371,P61981,Q15154,P61163,Q14203,Q7Z460,Q15691,P07437,P63208,Q13409,P17612,P63167,O94927 13 +Vegfr2 mediated vascular permeability 0.348286676406898 0.2116999481082256 0.8323411285860787 1.0 1.0 9 P31751,P42345 2 +The role of gtse1 in g2 m progression after g2 checkpoint 0.3139734878930079 0.2056557042991054 0.8370598617046869 1.0 1.0 45 P28072,P60900,P49721 3 +Assembly and cell surface presentation of nmda receptors 0.3698388327565067 0.2047891823577618 0.8377368391267692 1.0 1.0 8 Q9BUF5 1 +Glucagon like peptide 1 glp1 regulates insulin secretion 0.4238464679461092 0.1959484315184425 0.8446505291113835 1.0 1.0 4 P17612,P10644,P13861 3 +Extra nuclear estrogen signaling 0.3904799274177647 0.1954035527768051 0.8450770355085369 1.0 1.0 7 Q99873 1 +Rho gtpases activate rocks 0.3887014373872738 0.1912762339720971 0.8483091798612341 1.0 1.0 7 P35579,O75116 2 +Negative regulators of ddx58 ifih1 signaling 0.4209881584320214 0.190061708617787 0.84926077520407 1.0 1.0 4 Q96J02,Q14258,P61086 3 +Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.3876094393232634 0.1887632395489358 0.8502783844179831 1.0 1.0 7 Q16763 1 +Downregulation of smad2 3 smad4 transcriptional activity 0.4101725342468422 0.1844202583377359 0.8536837785223836 1.0 1.0 6 Q13573 1 +Transcriptional activity of smad2 smad3 smad4 heterotrimer 0.4101725342468422 0.1844202583377359 0.8536837785223836 1.0 1.0 6 Q13573 1 +Parasite infection 0.3307167405360552 0.1772965150083172 0.859275488052744 1.0 1.0 14 Q9UQB8 1 +Sema4d induced cell migration and growth cone collapse 0.403537259461147 0.1708256853548497 0.8643608319318308 1.0 1.0 6 P35579,O75116 2 +Muscle contraction 0.3139526888649427 0.1677935062926162 0.86674573129838 1.0 1.0 23 Q9NYL9,P30626,Q13177,P05026,P54709,O43865,P17612,P23634,P20020 9 +Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 0.308241300000436 0.1671875688763772 0.8672224653537994 1.0 1.0 45 P28072,P60900,P49721 3 +Regulation of runx3 expression and activity 0.3126975630426758 0.1606198960111821 0.8723927836114256 1.0 1.0 35 P28072,P49721 2 +Josephin domain dubs 0.3647490820073473 0.1588958758320209 0.8737509100247045 1.0 1.0 2 P54727 1 +Aurka activation by tpx2 0.3102718056794354 0.1575983587266315 0.8747732969570587 1.0 1.0 24 P61981,Q15154,P61163,Q14203,Q7Z460,Q15691,P07437,P68371,P17612,P63167,O94927 11 +Hiv transcription initiation 0.346286249075286 0.1481803378969624 0.8822004485909052 1.0 1.0 8 P29083 1 +Signaling by alk in cancer 0.3112575261571239 0.1456344845969564 0.8842099434328499 1.0 1.0 28 Q13501 1 +Rhod gtpase cycle 0.3105638402932528 0.145050992677528 0.8846706111429974 1.0 1.0 21 Q9Y2U8,P50402,Q14739,Q658P3 4 +Met promotes cell motility 0.3895552770810777 0.1427083415810583 0.8865205285244036 1.0 1.0 5 P05556 1 +Diseases of mismatch repair mmr 0.3963265306122401 0.1396936362429354 0.8889020546466575 1.0 1.0 3 P52701,P20585 2 +Prevention of phagosomal lysosomal fusion 0.3942857142857078 0.1364133387148274 0.8914945294782697 1.0 1.0 3 P51149,Q9H267 2 +Cross presentation of soluble exogenous antigens endosomes 0.3068420786553162 0.1326740565172362 0.894451161349904 1.0 1.0 36 P28072,P49721 2 +Degradation of axin 0.3068420786553162 0.1326740565172362 0.894451161349904 1.0 1.0 36 P28072,P49721 2 +Runx1 interacts with co factors whose precise effect on runx1 targets is not known 0.3174728586695727 0.1306299351578642 0.8960680608010514 1.0 1.0 11 P67870 1 +Transcriptional regulation by runx3 0.3022265947617545 0.1283026872933131 0.8979094385315787 1.0 1.0 39 P28072,P60900,Q13573,P49721 4 +Pkmts methylate histone lysines 0.379604962188919 0.1264589680927745 0.8993686269546528 1.0 1.0 6 Q9H7B4 1 +Stabilization of p53 0.3036108249254438 0.1203892661960526 0.9041747938938314 1.0 1.0 37 P28072,P49721 2 +Negative regulation of notch4 signaling 0.3016744310292215 0.1163970148896906 0.9073379010876732 1.0 1.0 38 P28072,P49721 2 +Rna polymerase iii transcription initiation from type 3 promoter 0.3788444829146558 0.1158140840097972 0.907799888204041 1.0 1.0 4 O14802,O15160 2 +Rna polymerase iii chain elongation 0.3788444829146558 0.1158140840097972 0.907799888204041 1.0 1.0 4 O14802,O15160 2 +Cdt1 association with the cdc6 orc origin complex 0.3023951381450444 0.1134466134389044 0.9096764860368158 1.0 1.0 37 P28072,P49721 2 +Interleukin 12 signaling 0.3041315076757106 0.1109847031156765 0.9116284769322428 1.0 1.0 28 P11233,Q13126,O00170,O14979 4 +Metabolism of polyamines 0.3011627624154736 0.1064584021249406 0.915218658091427 1.0 1.0 37 P28072,P49721 2 +Homology directed repair 0.3021565252430717 0.1020269175538224 0.9187353094473594 1.0 1.0 35 Q9UQ84,P38398,P54132,Q9UNS1 4 +Formation of tubulin folding intermediates by cct tric 0.3058968058968059 0.1016676796797262 0.9190204570576176 1.0 1.0 11 P50990,P50991,P17987,P78371,Q9BUF5,Q9BVA1,P68371,P49368,P48643,Q99832 10 +Pentose phosphate pathway 0.3627602815447608 0.0996858266923257 0.9205937531496556 1.0 1.0 6 O95336 1 +Ras processing 0.3663366970002756 0.098320696835425 0.9216776441068028 1.0 1.0 4 P49356 1 +Asymmetric localization of pcp proteins 0.2989918614197332 0.0942723104910253 0.9248928449638928 1.0 1.0 37 P28072,P49721 2 +Downstream signaling events of b cell receptor bcr 0.2976381605298093 0.0931436757346356 0.9257894200119696 1.0 1.0 38 P28072,P49721 2 +Regulation of hmox1 expression and activity 0.2953124103685024 0.0862368609048021 0.9312781290734872 1.0 1.0 44 P28072,P67870,P49721 3 +Sumoylation of transcription factors 0.3542857142857091 0.0833295338490164 0.9335895173371478 1.0 1.0 3 Q12888,P04637 2 +Regulation of runx2 expression and activity 0.2933644244064713 0.0818945065206797 0.9347306029284616 1.0 1.0 41 P28072,P49721 2 +Degradation of dvl 0.2955919789248261 0.0755137808832646 0.9398059332840438 1.0 1.0 37 P28072,P49721 2 +Regulation of ras by gaps 0.2955919789248261 0.0755137808832646 0.9398059332840438 1.0 1.0 37 P28072,P49721 2 +Nephrin family interactions 0.3449121373109974 0.0753225686834132 0.9399580652742454 1.0 1.0 6 P12814,Q13813,P46940,Q9Y5K6,O43707 5 +Interaction between l1 and ankyrins 0.3444897959183621 0.073443769850901 0.9414529883137496 1.0 1.0 3 Q13813,Q12955 2 +Ncam signaling for neurite out growth 0.3444897959183612 0.0734437698509005 0.94145298831375 1.0 1.0 3 Q13813,P62993 2 +Wnt5a dependent internalization of fzd2 fzd5 and ror2 0.3406862745098057 0.0718194608427406 0.9427455852993872 1.0 1.0 5 Q00610,O95782,Q96CW1,P63010 4 +Wnt5a dependent internalization of fzd4 0.3406862745098057 0.0718194608427406 0.9427455852993872 1.0 1.0 5 Q00610,O95782,Q96CW1,P63010 4 +Nef mediated cd8 down regulation 0.3406862745098056 0.0718194608427406 0.9427455852993872 1.0 1.0 5 O95782,Q96CW1,Q9UI12,P63010 4 +Vldlr internalisation and degradation 0.3406862745098057 0.0718194608427406 0.9427455852993872 1.0 1.0 5 Q00610,O95782,Q96CW1,P63010 4 +Nef mediated cd4 down regulation 0.3406862745098056 0.0718194608427406 0.9427455852993872 1.0 1.0 5 O95782,Q96CW1,Q9UI12,P63010 4 +Retrograde neurotrophin signalling 0.3408255006129942 0.0703139247730215 0.9439437995731396 1.0 1.0 6 P63010,P50570,Q00610,O95782,Q96CW1 5 +Collagen formation 0.2938631768032457 0.0692797215828344 0.9447669667815152 1.0 1.0 13 O60568,P13674,O15460 3 +Rna polymerase iii transcription termination 0.3346806899317542 0.0652325210300963 0.9479888682247388 1.0 1.0 5 O14802,P19388,O15160 3 +Signaling by notch 0.2929577236055524 0.0651785045705841 0.9480318755980646 1.0 1.0 51 P60900,P49721,Q92542,Q13573,P28072 5 +Sumo is transferred from e1 to e2 ube2i ubc9 0.2774377804977499 0.0527514303751163 0.9579299605248262 1.0 1.0 2 Q9UBT2 1 +Processing and activation of sumo 0.2774377804977499 0.0527514303751163 0.9579299605248262 1.0 1.0 2 Q9UBT2 1 +Sumo is conjugated to e1 uba2 sae1 0.2774377804977499 0.0527514303751163 0.9579299605248262 1.0 1.0 2 Q9UBT2 1 +Biosynthesis of specialized proresolving mediators spms 0.2753977968176189 0.0515608484154753 0.9588786162584692 1.0 1.0 2 P09960 1 +Synthesis of leukotrienes lt and eoxins ex 0.2753977968176189 0.0515608484154753 0.9588786162584692 1.0 1.0 2 P09960 1 +Aggrephagy 0.2814420319541107 0.0445443035586 0.9644705378706292 1.0 1.0 12 P61088,P08670,Q9BUF5,Q14204,Q9BVA1,P55072,P68371,Q13409,P07900,Q9Y6G9,P63167 11 +Trafficking of glur2 containing ampa receptors 0.3092320261437931 0.0420639029661398 0.966447755947671 1.0 1.0 5 O95782,O94973,Q96CW1,P63010 4 +Response of mtb to phagocytosis 0.2717969709373735 0.0381788753977883 0.9695450636048204 1.0 1.0 10 P00558,P49840,P51149,Q9UI12,P20339,Q9H267,Q14974,P23246,P52294 9 +Infection with mycobacterium tuberculosis 0.2717969709373735 0.0381788753977883 0.9695450636048204 1.0 1.0 10 P00558,P49840,P51149,Q9UI12,P20339,Q9H267,Q14974,P23246,P52294 9 +Circadian clock 0.3085410706988165 0.0378355070258407 0.9698188341175646 1.0 1.0 6 Q86X55,P63208,Q9BWF3,Q13616,P43490 5 +Initiation of nuclear envelope ne reformation 0.2805215947933772 0.0355124054319476 0.9716711545112452 1.0 1.0 15 Q9Y2U8,Q14739 2 +Regulation of tp53 activity 0.2895575735905982 0.0346536091370161 0.9723559532340198 1.0 1.0 33 Q9UQ84,P67870,Q92804,P31751,P54132,P38398 6 +Signaling by ntrk2 trkb 0.2653061224489735 0.0292052986439975 0.976700855330904 1.0 1.0 3 P63000,P62993 2 +G1 s specific transcription 0.2703476482617513 0.0254583184467974 0.9796893947628074 1.0 1.0 8 Q13547,P06493,P04818,Q9Y619,P12004,P04183,P00374 7 +Degradation of gli1 by the proteasome 0.2825967798236318 0.0236945903709991 0.9810962210544658 1.0 1.0 40 P28072,P49721 2 +Cytosolic iron sulfur cluster assembly 0.2844527245792713 0.0210718304994208 0.9831883559092822 1.0 1.0 6 Q6FI81 1 +Chrebp activates metabolic gene expression 0.2540849673202636 0.013851084830027 0.9889487866321264 1.0 1.0 5 Q99943,P53396,P49327,O00763 4 +Protein folding 0.2804902989711575 0.0070825996513248 0.9943489503337056 1.0 1.0 28 P67870,Q15477,Q9UHV9,Q9BUF5,Q99471,P04062,P68371 7 diff --git a/msigdb_reactome/selections.json b/msigdb_reactome/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..85baff6b893ae77b4128e1b35a0c621948eb4b50 --- /dev/null +++ b/msigdb_reactome/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2 ltr circle formation", "Abacavir metabolism", "Abacavir transmembrane transport", "Abacavir transport and metabolism", "Abc family proteins mediated transport", "Abc transporter disorders", "Abc transporters in lipid homeostasis", "Aberrant regulation of mitotic exit in cancer due to rb1 defects", "Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects", "Abortive elongation of hiv 1 transcript in the absence of tat", "Acetylcholine regulates insulin secretion", "Activated notch1 transmits signal to the nucleus", "Activated ntrk2 signals through cdk5", "Activated ntrk2 signals through frs2 and frs3", "Activated ntrk2 signals through fyn", "Activated ntrk2 signals through pi3k", "Activated ntrk2 signals through ras", "Activated ntrk3 signals through ras", "Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3", "Activated tak1 mediates p38 mapk activation", "Activation of ampk downstream of nmdars", "Activation of anterior hox genes in hindbrain development during early embryogenesis", "Activation of atr in response to replication stress", "Activation of bad and translocation to mitochondria", "Activation of bh3 only proteins", "Activation of gene expression by srebf srebp", "Activation of kainate receptors upon glutamate binding", "Activation of nima kinases nek9 nek6 nek7", "Activation of nmda receptors and postsynaptic events", "Activation of noxa and translocation to mitochondria", "Activation of puma and translocation to mitochondria", "Activation of rac1", "Activation of rac1 downstream of nmdars", "Activation of smo", "Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s", "Activation of the pre replicative complex", "Activation of the tfap2 ap 2 family of transcription factors", "Acyl chain remodeling of cl", "Acyl chain remodelling of pc", "Acyl chain remodelling of pg", "Acyl chain remodelling of pi", "Adaptive immune system", "Adenylate cyclase inhibitory pathway", "Adherens junctions interactions", "Adora2b mediated anti inflammatory cytokines production", "Adp signalling through p2y purinoceptor 12", "Adrenaline noradrenaline inhibits insulin secretion", "Advanced glycosylation endproduct receptor signaling", "Aflatoxin activation and detoxification", "Aggrephagy", "Akt phosphorylates targets in the cytosol", "Akt phosphorylates targets in the nucleus", "Alk mutants bind tkis", "Alpha linolenic omega3 and linoleic omega6 acid metabolism", "Alpha oxidation of phytanate", "Amino acid transport across the plasma membrane", "Amino acids regulate mtorc1", "Amyloid fiber formation", "Anchoring of the basal body to the plasma membrane", "Androgen biosynthesis", "Anti inflammatory response favouring leishmania parasite infection", "Antigen activates b cell receptor bcr leading to generation of second messengers", "Antigen presentation folding assembly and peptide loading of class i mhc", "Antigen processing cross presentation", "Antigen processing ubiquitination proteasome degradation", "Antimicrobial peptides", "Antiviral mechanism by ifn stimulated genes", "Apc c cdc20 mediated degradation of cyclin b", "Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1", "Apc c mediated degradation of cell cycle proteins", "Apc cdc20 mediated degradation of nek2a", "Apex1 independent resolution of ap sites via the single nucleotide replacement pathway", "Apobec3g mediated resistance to hiv 1 infection", "Apoptosis", "Apoptosis induced dna fragmentation", "Apoptotic cleavage of cell adhesion proteins", "Apoptotic cleavage of cellular proteins", "Apoptotic execution phase", "Apoptotic factor mediated response", "Aquaporin mediated transport", "Arachidonate production from dag", "Arachidonic acid metabolism", "Arms mediated activation", "Aryl hydrocarbon receptor signalling", "Asparagine n linked glycosylation", "Aspartate and asparagine metabolism", "Assembly and cell surface presentation of nmda receptors", "Assembly of collagen fibrils and other multimeric structures", "Assembly of the hiv virion", "Assembly of the orc complex at the origin of replication", "Association of tric cct with target proteins during biosynthesis", "Asymmetric localization of pcp proteins", "Atf4 activates genes in response to endoplasmic reticulum stress", "Atf6 atf6 alpha activates chaperone genes", "Atf6 atf6 alpha activates chaperones", "Attachment and entry", "Attachment of gpi anchor to upar", "Attenuation phase", "Auf1 hnrnp d0 binds and destabilizes mrna", "Aurka activation by tpx2", "Autophagy", "B wich complex positively regulates rrna expression", "Base excision repair", "Base excision repair ap site formation", "Basigin interactions", "Bbsome mediated cargo targeting to cilium", "Beta catenin independent wnt signaling", "Beta catenin phosphorylation cascade", "Beta oxidation of butanoyl coa to acetyl coa", "Beta oxidation of decanoyl coa to octanoyl coa coa", "Beta oxidation of hexanoyl coa to butanoyl coa", "Beta oxidation of lauroyl coa to decanoyl coa coa", "Beta oxidation of octanoyl coa to hexanoyl coa", "Beta oxidation of pristanoyl coa", "Beta oxidation of very long chain fatty acids", "Bh3 only proteins associate with and inactivate anti apoptotic bcl 2 members", "Bile acid and bile salt metabolism", "Binding and uptake of ligands by scavenger receptors", "Binding of tcf lef ctnnb1 to target gene promoters", "Biological oxidations", "Biosynthesis of epa derived spms", "Biosynthesis of specialized proresolving mediators spms", "Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein", "Biotin transport and metabolism", "Bmal1 clock npas2 activates circadian gene expression", "Branched chain amino acid catabolism", "Budding and maturation of hiv virion", "Butyrate response factor 1 brf1 binds and destabilizes mrna", "C type lectin receptors clrs", "Ca dependent events", "Ca2 pathway", "Calnexin calreticulin cycle", "Camk iv mediated phosphorylation of creb", "Carboxyterminal post translational modifications of tubulin", "Cardiac conduction", "Cargo concentration in the er", "Cargo recognition for clathrin mediated endocytosis", "Cargo trafficking to the periciliary membrane", "Carnitine metabolism", "Caspase activation via death receptors in the presence of ligand", "Caspase activation via extrinsic apoptotic signalling pathway", "Caspase mediated cleavage of cytoskeletal proteins", "Cation coupled chloride cotransporters", "Cd163 mediating an anti inflammatory response", "Cd209 dc sign signaling", "Cd28 co stimulation", "Cd28 dependent pi3k akt signaling", "Cd28 dependent vav1 pathway", "Cdc42 gtpase cycle", "Cdc6 association with the orc origin complex", "Cdt1 association with the cdc6 orc origin complex", "Cell cell communication", "Cell cell junction organization", "Cell cycle", "Cell cycle checkpoints", "Cell cycle mitotic", "Cell death signalling via nrage nrif and nade", "Cell extracellular matrix interactions", "Cell junction organization", "Cell surface interactions at the vascular wall", "Cellular response to chemical stress", "Cellular response to heat stress", "Cellular response to hypoxia", "Cellular response to starvation", "Cellular responses to stimuli", "Cellular senescence", "Chaperone mediated autophagy", "Chemokine receptors bind chemokines", "Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex", "Chl1 interactions", "Cholesterol biosynthesis", "Choline catabolism", "Chondroitin sulfate dermatan sulfate metabolism", "Chrebp activates metabolic gene expression", "Chromatin modifying enzymes", "Chromosome maintenance", "Chylomicron assembly", "Cilium assembly", "Circadian clock", "Citric acid cycle tca cycle", "Class a 1 rhodopsin like receptors", "Class b 2 secretin family receptors", "Class i mhc mediated antigen processing presentation", "Class i peroxisomal membrane protein import", "Clathrin mediated endocytosis", "Clec7a dectin 1 induces nfat activation", "Clec7a dectin 1 signaling", "Cobalamin cbl vitamin b12 transport and metabolism", "Coenzyme a biosynthesis", "Cohesin loading onto chromatin", "Collagen biosynthesis and modifying enzymes", "Collagen degradation", "Collagen formation", "Competing endogenous rnas cernas regulate pten translation", "Complement cascade", "Complex i biogenesis", "Condensation of prometaphase chromosomes", "Condensation of prophase chromosomes", "Constitutive signaling by aberrant pi3k in cancer", "Constitutive signaling by akt1 e17k in cancer", "Constitutive signaling by egfrviii", "Constitutive signaling by ligand responsive egfr cancer variants", "Constitutive signaling by overexpressed erbb2", "Conversion from apc c cdc20 to apc c cdh1 in late anaphase", "Cooperation of pdcl phlp1 and tric cct in g protein beta folding", "Cooperation of prefoldin and tric cct in actin and tubulin folding", "Copi dependent golgi to er retrograde traffic", "Copi independent golgi to er retrograde traffic", "Copi mediated anterograde transport", "Copii mediated vesicle transport", "Costimulation by the cd28 family", "Creatine metabolism", "Creb phosphorylation", "Creb1 phosphorylation through nmda receptor mediated activation of ras signaling", "Creb1 phosphorylation through the activation of adenylate cyclase", "Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde", "Cristae formation", "Crmps in sema3a signaling", "Cross presentation of soluble exogenous antigens endosomes", "Cs ds degradation", "Ctla4 inhibitory signaling", "Cyclin a b1 b2 associated events during g2 m transition", "Cyclin a cdk2 associated events at s phase entry", "Cyclin d associated events in g1", "Cytochrome c mediated apoptotic response", "Cytochrome p450 arranged by substrate type", "Cytokine signaling in immune system", "Cytoprotection by hmox1", "Cytosolic iron sulfur cluster assembly", "Cytosolic sensors of pathogen associated dna", "Cytosolic sulfonation of small molecules", "Cytosolic trna aminoacylation", "Dag and ip3 signaling", "Dap12 interactions", "Dap12 signaling", "Darpp 32 events", "Dcc mediated attractive signaling", "Ddx58 ifih1 mediated induction of interferon alpha beta", "Deactivation of the beta catenin transactivating complex", "Deadenylation dependent mrna decay", "Deadenylation of mrna", "Death receptor signalling", "Dectin 1 mediated noncanonical nf kb signaling", "Defective cftr causes cystic fibrosis", "Defective chst14 causes eds musculocontractural type", "Defective factor ix causes hemophilia b", "Defective intrinsic pathway for apoptosis", "Defective ripk1 mediated regulated necrosis", "Defects in biotin btn metabolism", "Defects in cobalamin b12 metabolism", "Defects in vitamin and cofactor metabolism", "Defects of contact activation system cas and kallikrein kinin system kks", "Degradation of axin", "Degradation of beta catenin by the destruction complex", "Degradation of cysteine and homocysteine", "Degradation of dvl", "Degradation of gli1 by the proteasome", "Degradation of the extracellular matrix", "Depolymerisation of the nuclear lamina", "Deposition of new cenpa containing nucleosomes at the centromere", "Dermatan sulfate biosynthesis", "Detoxification of reactive oxygen species", "Deubiquitination", "Developmental biology", "Dex h box helicases activate type i ifn and inflammatory cytokines production", "Digestion", "Digestion and absorption", "Disassembly of the destruction complex and recruitment of axin to the membrane", "Diseases associated with glycosaminoglycan metabolism", "Diseases associated with glycosylation precursor biosynthesis", "Diseases associated with n glycosylation of proteins", "Diseases associated with o glycosylation of proteins", "Diseases of carbohydrate metabolism", "Diseases of dna repair", "Diseases of glycosylation", "Diseases of immune system", "Diseases of metabolism", "Diseases of mismatch repair mmr", "Diseases of mitotic cell cycle", "Diseases of programmed cell death", "Diseases of signal transduction by growth factor receptors and second messengers", "Disinhibition of snare formation", "Disorders of transmembrane transporters", "Displacement of dna glycosylase by apex1", "Dissolution of fibrin clot", "Dna damage bypass", "Dna damage recognition in gg ner", "Dna damage reversal", "Dna damage telomere stress induced senescence", "Dna double strand break repair", "Dna double strand break response", "Dna methylation", "Dna repair", "Dna replication", "Dna replication initiation", "Dna replication pre initiation", "Dna strand elongation", "Dopamine clearance from the synaptic cleft", "Downregulation of erbb2 erbb3 signaling", "Downregulation of erbb2 signaling", "Downregulation of erbb4 signaling", "Downregulation of smad2 3 smad4 transcriptional activity", "Downregulation of tgf beta receptor signaling", "Downstream signal transduction", "Downstream signaling events of b cell receptor bcr", "Downstream signaling of activated fgfr1", "Downstream signaling of activated fgfr2", "Downstream signaling of activated fgfr3", "Downstream signaling of activated fgfr4", "Dscam interactions", "Dual incision in gg ner", "Dual incision in tc ner", "E2f enabled inhibition of pre replication complex formation", "E2f mediated regulation of dna replication", "E3 ubiquitin ligases ubiquitinate target proteins", "Early phase of hiv life cycle", "Ecm proteoglycans", "Effects of pip2 hydrolysis", "Egfr downregulation", "Egfr transactivation by gastrin", "Egr2 and sox10 mediated initiation of schwann cell myelination", "Elastic fibre formation", "Endogenous sterols", "Endosomal sorting complex required for transport escrt", "Endosomal vacuolar pathway", "Energy dependent regulation of mtor by lkb1 ampk", "Enos activation", "Eph ephrin mediated repulsion of cells", "Eph ephrin signaling", "Epha mediated growth cone collapse", "Ephb mediated forward signaling", "Ephrin signaling", "Epigenetic regulation of gene expression", "Er quality control compartment erqc", "Er to golgi anterograde transport", "Erbb2 regulates cell motility", "Ercc6 csb and ehmt2 g9a positively regulate rrna expression", "Erk mapk targets", "Erks are inactivated", "Erythrocytes take up carbon dioxide and release oxygen", "Erythropoietin activates ras", "Esr mediated signaling", "Establishment of sister chromatid cohesion", "Estrogen dependent gene expression", "Estrogen dependent nuclear events downstream of esr membrane signaling", "Ethanol oxidation", "Eukaryotic translation elongation", "Eukaryotic translation initiation", "Export of viral ribonucleoproteins from nucleus", "Extension of telomeres", "Extra nuclear estrogen signaling", "Extracellular matrix organization", "Factors involved in megakaryocyte development and platelet production", "Fanconi anemia pathway", "Fasl cd95l signaling", "Fatty acid metabolism", "Fatty acyl coa biosynthesis", "Fbxw7 mutants and notch1 in cancer", "Fc epsilon receptor fceri signaling", "Fceri mediated ca 2 mobilization", "Fceri mediated mapk activation", "Fceri mediated nf kb activation", "Fcgamma receptor fcgr dependent phagocytosis", "Fcgr3a mediated il10 synthesis", "Fgfr1 mutant receptor activation", "Fgfr2 alternative splicing", "Fgfr2 mutant receptor activation", "Fibronectin matrix formation", "Flt3 signaling", "Flt3 signaling in disease", "Folding of actin by cct tric", "Formation of apoptosome", "Formation of atp by chemiosmotic coupling", "Formation of fibrin clot clotting cascade", "Formation of incision complex in gg ner", "Formation of rna pol ii elongation complex", "Formation of senescence associated heterochromatin foci sahf", "Formation of tc ner pre incision complex", "Formation of the beta catenin tcf transactivating complex", "Formation of the cornified envelope", "Formation of the early elongation complex", "Formation of tubulin folding intermediates by cct tric", "Formation of xylulose 5 phosphate", "Formyl peptide receptors bind formyl peptides and many other ligands", "Foxo mediated transcription", "Foxo mediated transcription of oxidative stress metabolic and neuronal genes", "Free fatty acids regulate insulin secretion", "Frs mediated fgfr1 signaling", "Frs mediated fgfr2 signaling", "Frs mediated fgfr3 signaling", "Frs mediated fgfr4 signaling", "Fructose metabolism", "G alpha 12 13 signalling events", "G alpha i signalling events", "G alpha q signalling events", "G alpha s signalling events", "G alpha z signalling events", "G beta gamma signalling through cdc42", "G beta gamma signalling through pi3kgamma", "G protein beta gamma signalling", "G protein mediated events", "G0 and early g1", "G1 s dna damage checkpoints", "G1 s specific transcription", "G2 m checkpoints", "G2 m dna damage checkpoint", "G2 m dna replication checkpoint", "G2 phase", "Gab1 signalosome", "Gaba b receptor activation", "Gaba receptor activation", "Gaba synthesis release reuptake and degradation", "Galactose catabolism", "Gamma carboxylation hypusine formation and arylsulfatase activation", "Gamma carboxylation transport and amino terminal cleavage of proteins", "Gap filling dna repair synthesis and ligation in gg ner", "Gap junction assembly", "Gap junction degradation", "Gap junction trafficking and regulation", "Gastrin creb signalling pathway via pkc and mapk", "Gdp fucose biosynthesis", "Gene and protein expression by jak stat signaling after interleukin 12 stimulation", "Gene silencing by rna", "Generation of second messenger molecules", "Global genome nucleotide excision repair gg ner", "Glucagon like peptide 1 glp1 regulates insulin secretion", "Glucagon signaling in metabolic regulation", "Gluconeogenesis", "Glucose metabolism", "Glucuronidation", "Glutamate and glutamine metabolism", "Glutamate neurotransmitter release cycle", "Glutathione conjugation", "Glutathione synthesis and recycling", "Glycerophospholipid biosynthesis", "Glycerophospholipid catabolism", "Glycogen breakdown glycogenolysis", "Glycogen metabolism", "Glycogen storage diseases", "Glycogen synthesis", "Glycolysis", "Glycosaminoglycan metabolism", "Glycosphingolipid metabolism", "Glyoxylate metabolism and glycine degradation", "Golgi associated vesicle biogenesis", "Golgi cisternae pericentriolar stack reorganization", "Golgi to er retrograde transport", "Gp1b ix v activation signalling", "Gpcr ligand binding", "Gpvi mediated activation cascade", "Grb2 events in erbb2 signaling", "Grb2 sos provides linkage to mapk signaling for integrins", "Growth hormone receptor signaling", "Hats acetylate histones", "Hcmv early events", "Hcmv infection", "Hcmv late events", "Hdacs deacetylate histones", "Hdl assembly", "Hdl clearance", "Hdms demethylate histones", "Hdr through homologous recombination hrr", "Hdr through mmej alt nhej", "Hdr through single strand annealing ssa", "Hedgehog ligand biogenesis", "Hedgehog off state", "Hedgehog on state", "Heme biosynthesis", "Heme degradation", "Heme signaling", "Hemostasis", "Heparan sulfate heparin hs gag metabolism", "Hiv elongation arrest and recovery", "Hiv infection", "Hiv life cycle", "Hiv transcription elongation", "Hiv transcription initiation", "Homologous dna pairing and strand exchange", "Homology directed repair", "Host interactions of hiv factors", "Hs gag degradation", "Hsf1 activation", "Hsf1 dependent transactivation", "Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand", "Hur elavl1 binds and stabilizes mrna", "Hyaluronan metabolism", "Hyaluronan uptake and degradation", "Ikk complex recruitment mediated by rip1", "Immunoregulatory interactions between a lymphoid and a non lymphoid cell", "Inactivation of cdc42 and rac1", "Inactivation of csf3 g csf signaling", "Incretin synthesis secretion and inactivation", "Infection with mycobacterium tuberculosis", "Infectious disease", "Inflammasomes", "Influenza infection", "Inhibition of dna recombination at telomere", "Inhibition of replication initiation of damaged dna by rb1 e2f1", "Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components", "Initiation of nuclear envelope ne reformation", "Inla mediated entry of listeria monocytogenes into host cells", "Inlb mediated entry of listeria monocytogenes into host cell", "Innate immune system", "Inositol phosphate metabolism", "Insertion of tail anchored proteins into the endoplasmic reticulum membrane", "Insulin processing", "Insulin receptor recycling", "Insulin receptor signalling cascade", "Integration of energy metabolism", "Integration of provirus", "Integrin cell surface interactions", "Integrin signaling", "Interaction between l1 and ankyrins", "Interactions of rev with host cellular proteins", "Interactions of vpr with host cellular proteins", "Interconversion of nucleotide di and triphosphates", "Interferon alpha beta signaling", "Interferon gamma signaling", "Interferon signaling", "Interleukin 1 family signaling", "Interleukin 1 signaling", "Interleukin 10 signaling", "Interleukin 12 family signaling", "Interleukin 12 signaling", "Interleukin 15 signaling", "Interleukin 17 signaling", "Interleukin 2 family signaling", "Interleukin 20 family signaling", "Interleukin 21 signaling", "Interleukin 23 signaling", "Interleukin 27 signaling", "Interleukin 3 interleukin 5 and gm csf signaling", "Interleukin 35 signalling", "Interleukin 37 signaling", "Interleukin 4 and interleukin 13 signaling", "Interleukin 6 family signaling", "Interleukin 6 signaling", "Interleukin 7 signaling", "Interleukin 9 signaling", "Interleukin receptor shc signaling", "Intra golgi and retrograde golgi to er traffic", "Intra golgi traffic", "Intracellular signaling by second messengers", "Intraflagellar transport", "Intrinsic pathway for apoptosis", "Intrinsic pathway of fibrin clot formation", "Ion channel transport", "Ion homeostasis", "Ion transport by p type atpases", "Ionotropic activity of kainate receptors", "Irak1 recruits ikk complex", "Irak4 deficiency tlr2 4", "Ire1alpha activates chaperones", "Irf3 mediated activation of type 1 ifn", "Irf3 mediated induction of type i ifn", "Iron uptake and transport", "Irs mediated signalling", "Jnk c jun kinases phosphorylation and activation mediated by activated human tak1", "Josephin domain dubs", "Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Keratan sulfate keratin metabolism", "Keratinization", "Ketone body metabolism", "Killing mechanisms", "Kinesins", "Ksrp khsrp binds and destabilizes mrna", "L1cam interactions", "Lagging strand synthesis", "Laminin interactions", "Late endosomal microautophagy", "Ldl clearance", "Ldl remodeling", "Leishmania infection", "Lgi adam interactions", "Linoleic acid la metabolism", "Lipophagy", "Listeria monocytogenes entry into host cells", "Long term potentiation", "Loss of function of mecp2 in rett syndrome", "Loss of mecp2 binding ability to the ncor smrt complex", "Lrr flii interacting protein 1 lrrfip1 activates type i ifn production", "Lysine catabolism", "Lysosome vesicle biogenesis", "M phase", "Map2k and mapk activation", "Map3k8 tpl2 dependent mapk1 3 activation", "Mapk family signaling cascades", "Mapk targets nuclear events mediated by map kinases", "Mapk3 erk1 activation", "Mapk6 mapk4 signaling", "Mastl facilitates mitotic progression", "Maturation of protein 3a", "Maturation of sars cov 1 nucleoprotein", "Maturation of sars cov 1 spike protein", "Maturation of sars cov 2 nucleoprotein", "Maturation of sars cov 2 spike protein", "Mecp2 regulates neuronal receptors and channels", "Mecp2 regulates transcription factors", "Mecp2 regulates transcription of neuronal ligands", "Meiosis", "Meiotic recombination", "Meiotic synapsis", "Membrane trafficking", "Met activates pi3k akt signaling", "Met activates ptk2 signaling", "Met activates ptpn11", "Met activates rap1 and rac1", "Met activates ras signaling", "Met interacts with tns proteins", "Met promotes cell motility", "Met receptor recycling", "Metabolic disorders of biological oxidation enzymes", "Metabolism of amino acids and derivatives", "Metabolism of carbohydrates", "Metabolism of cofactors", "Metabolism of fat soluble vitamins", "Metabolism of folate and pterines", "Metabolism of ingested semet sec mesec into h2se", "Metabolism of lipids", "Metabolism of nitric oxide nos3 activation and regulation", "Metabolism of nucleotides", "Metabolism of polyamines", "Metabolism of porphyrins", "Metabolism of rna", "Metabolism of steroid hormones", "Metabolism of steroids", "Metabolism of vitamins and cofactors", "Metabolism of water soluble vitamins and cofactors", "Metalloprotease dubs", "Methionine salvage pathway", "Methylation", "Mhc class ii antigen presentation", "Microrna mirna biogenesis", "Miro gtpase cycle", "Miscellaneous transport and binding events", "Mismatch repair", "Mitochondrial biogenesis", "Mitochondrial calcium ion transport", "Mitochondrial fatty acid beta oxidation", "Mitochondrial fatty acid beta oxidation of saturated fatty acids", "Mitochondrial fatty acid beta oxidation of unsaturated fatty acids", "Mitochondrial iron sulfur cluster biogenesis", "Mitochondrial protein import", "Mitochondrial translation", "Mitochondrial trna aminoacylation", "Mitophagy", "Mitotic g1 phase and g1 s transition", "Mitotic g2 g2 m phases", "Mitotic metaphase and anaphase", "Mitotic prometaphase", "Mitotic prophase", "Mitotic spindle checkpoint", "Mitotic telophase cytokinesis", "Molecules associated with elastic fibres", "Mrna capping", "Mrna decay by 3 to 5 exoribonuclease", "Mrna decay by 5 to 3 exoribonuclease", "Mrna editing", "Mrna splicing", "Mrna splicing minor pathway", "Mtor signalling", "Mtorc1 mediated signalling", "Mucopolysaccharidoses", "Muscle contraction", "Myd88 independent tlr4 cascade", "Myoclonic epilepsy of lafora", "Myogenesis", "N glycan trimming in the er and calnexin calreticulin cycle", "Na cl dependent neurotransmitter transporters", "Nade modulates death signalling", "Ncam signaling for neurite out growth", "Nectin necl trans heterodimerization", "Neddylation", "Nef and signal transduction", "Nef mediated cd4 down regulation", "Nef mediated cd8 down regulation", "Nef mediated downregulation of mhc class i complex cell surface expression", "Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters", "Negative epigenetic regulation of rrna expression", "Negative feedback regulation of mapk pathway", "Negative regulation of fgfr1 signaling", "Negative regulation of fgfr2 signaling", "Negative regulation of fgfr3 signaling", "Negative regulation of fgfr4 signaling", "Negative regulation of flt3", "Negative regulation of mapk pathway", "Negative regulation of met activity", "Negative regulation of nmda receptor mediated neuronal transmission", "Negative regulation of notch4 signaling", "Negative regulation of the pi3k akt network", "Negative regulators of ddx58 ifih1 signaling", "Nephrin family interactions", "Nervous system development", "Netrin 1 signaling", "Neurexins and neuroligins", "Neuronal system", "Neurotransmitter clearance", "Neurotransmitter receptors and postsynaptic signal transmission", "Neurotransmitter release cycle", "Neutrophil degranulation", "Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10", "Nf kb is activated and signals survival", "Ngf stimulated transcription", "Nicotinamide salvaging", "Nicotinate metabolism", "Nod1 2 signaling pathway", "Non integrin membrane ecm interactions", "Noncanonical activation of notch3", "Nonhomologous end joining nhej", "Nonsense mediated decay nmd", "Nostrin mediated enos trafficking", "Notch hlh transcription pathway", "Notch1 intracellular domain regulates transcription", "Notch2 activation and transmission of signal to the nucleus", "Notch3 activation and transmission of signal to the nucleus", "Notch3 intracellular domain regulates transcription", "Notch4 activation and transmission of signal to the nucleus", "Notch4 intracellular domain regulates transcription", "Nr1h2 and nr1h3 mediated signaling", "Nr1h2 nr1h3 regulate gene expression linked to lipogenesis", "Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux", "Nrage signals death through jnk", "Nrcam interactions", "Nrif signals cell death from the nucleus", "Ns1 mediated effects on host pathways", "Ntrk2 activates rac1", "Nuclear envelope breakdown", "Nuclear envelope ne reassembly", "Nuclear events kinase and transcription factor activation", "Nuclear events stimulated by alk signaling in cancer", "Nuclear import of rev protein", "Nuclear pore complex npc disassembly", "Nuclear receptor transcription pathway", "Nuclear signaling by erbb4", "Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways", "Nucleotide biosynthesis", "Nucleotide catabolism", "Nucleotide excision repair", "Nucleotide salvage", "O linked glycosylation", "O linked glycosylation of mucins", "Oas antiviral response", "Oncogene induced senescence", "Oncogenic mapk signaling", "Opioid signalling", "Orc1 removal from chromatin", "Organelle biogenesis and maintenance", "Organic anion transporters", "Other interleukin signaling", "Other semaphorin interactions", "Ovarian tumor domain proteases", "Oxidative stress induced senescence", "P130cas linkage to mapk signaling for integrins", "P38mapk events", "P75 ntr receptor mediated signalling", "P75ntr negatively regulates cell cycle via sc1", "P75ntr recruits signalling complexes", "P75ntr regulates axonogenesis", "P75ntr signals via nf kb", "Parasite infection", "Pcna dependent long patch base excision repair", "Pcp ce pathway", "Pd 1 signaling", "Pentose phosphate pathway", "Peptide hormone metabolism", "Peptide ligand binding receptors", "Perk regulates gene expression", "Peroxisomal lipid metabolism", "Peroxisomal protein import", "Pexophagy", "Phase 0 rapid depolarisation", "Phase i functionalization of compounds", "Phase ii conjugation of compounds", "Phenylalanine and tyrosine metabolism", "Phenylalanine metabolism", "Phosphate bond hydrolysis by nudt proteins", "Phospholipid metabolism", "Phosphorylation of emi1", "Phosphorylation of the apc c", "Pi 3k cascade fgfr1", "Pi 3k cascade fgfr2", "Pi 3k cascade fgfr3", "Pi 3k cascade fgfr4", "Pi metabolism", "Pi3k akt activation", "Pi3k akt signaling in cancer", "Pi3k events in erbb2 signaling", "Pi5p regulates tp53 acetylation", "Pink1 prkn mediated mitophagy", "Piwi interacting rna pirna biogenesis", "Pka activation in glucagon signalling", "Pka mediated phosphorylation of creb", "Pka mediated phosphorylation of key metabolic factors", "Pkmts methylate histone lysines", "Plasma lipoprotein assembly", "Plasma lipoprotein assembly remodeling and clearance", "Plasma lipoprotein clearance", "Plasma lipoprotein remodeling", "Platelet activation signaling and aggregation", "Platelet adhesion to exposed collagen", "Platelet aggregation plug formation", "Platelet calcium homeostasis", "Platelet homeostasis", "Platelet sensitization by ldl", "Polb dependent long patch base excision repair", "Polo like kinase mediated events", "Polymerase switching", "Polymerase switching on the c strand of the telomere", "Positive epigenetic regulation of rrna expression", "Post chaperonin tubulin folding pathway", "Post translational modification synthesis of gpi anchored proteins", "Post translational protein modification", "Postmitotic nuclear pore complex npc reformation", "Potential therapeutics for sars", "Pou5f1 oct4 sox2 nanog activate genes related to proliferation", "Pp2a mediated dephosphorylation of key metabolic factors", "Prc2 methylates histones and dna", "Pre notch expression and processing", "Pre notch processing in golgi", "Pregnenolone biosynthesis", "Prevention of phagosomal lysosomal fusion", "Processing and activation of sumo", "Processing of capped intron containing pre mrna", "Processing of capped intronless pre mrna", "Processing of dna double strand break ends", "Processing of intronless pre mrnas", "Processing of smdt1", "Processive synthesis on the c strand of the telomere", "Processive synthesis on the lagging strand", "Programmed cell death", "Prolactin receptor signaling", "Prolonged erk activation events", "Propionyl coa catabolism", "Protein folding", "Protein localization", "Protein methylation", "Protein protein interactions at synapses", "Protein repair", "Protein ubiquitination", "Proton coupled monocarboxylate transport", "Pten regulation", "Ptk6 expression", "Ptk6 regulates cell cycle", "Ptk6 regulates proteins involved in rna processing", "Ptk6 regulates rho gtpases ras gtpase and map kinases", "Purine catabolism", "Purine ribonucleoside monophosphate biosynthesis", "Purine salvage", "Purinergic signaling in leishmaniasis infection", "Pyrimidine salvage", "Pyroptosis", "Pyruvate metabolism", "Pyruvate metabolism and citric acid tca cycle", "Ra biosynthesis pathway", "Rab gefs exchange gtp for gdp on rabs", "Rab geranylgeranylation", "Rab regulation of trafficking", "Rac1 gtpase cycle", "Rac2 gtpase cycle", "Rac3 gtpase cycle", "Raf activation", "Raf independent mapk1 3 activation", "Rap1 signalling", "Ras activation upon ca2 influx through nmda receptor", "Ras processing", "Receptor mediated mitophagy", "Recognition and association of dna glycosylase with site containing an affected purine", "Recognition of dna damage by pcna containing replication complex", "Recruitment of mitotic centrosome proteins and complexes", "Recruitment of numa to mitotic centrosomes", "Recycling of eif2 gdp", "Recycling pathway of l1", "Reduction of cytosolic ca levels", "Regulated necrosis", "Regulated proteolysis of p75ntr", "Regulation by c flip", "Regulation of bach1 activity", "Regulation of beta cell development", "Regulation of cholesterol biosynthesis by srebp srebf", "Regulation of commissural axon pathfinding by slit and robo", "Regulation of cytoskeletal remodeling and cell spreading by ipp complex components", "Regulation of expression of slits and robos", "Regulation of fzd by ubiquitination", "Regulation of gene expression in beta cells", "Regulation of gene expression in early pancreatic precursor cells", "Regulation of gene expression in late stage branching morphogenesis pancreatic bud precursor cells", "Regulation of glucokinase by glucokinase regulatory protein", "Regulation of glycolysis by fructose 2 6 bisphosphate metabolism", "Regulation of hmox1 expression and activity", "Regulation of hsf1 mediated heat shock response", "Regulation of ifna signaling", "Regulation of ifng signaling", "Regulation of innate immune responses to cytosolic dna", "Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps", "Regulation of insulin secretion", "Regulation of kit signaling", "Regulation of lipid metabolism by pparalpha", "Regulation of localization of foxo transcription factors", "Regulation of mecp2 expression and activity", "Regulation of mrna stability by proteins that bind au rich elements", "Regulation of plk1 activity at g2 m transition", "Regulation of pten gene transcription", "Regulation of pten localization", "Regulation of pten mrna translation", "Regulation of pten stability and activity", "Regulation of pyruvate dehydrogenase pdh complex", "Regulation of ras by gaps", "Regulation of runx1 expression and activity", "Regulation of runx2 expression and activity", "Regulation of runx3 expression and activity", "Regulation of signaling by cbl", "Regulation of tlr by endogenous ligand", "Regulation of tnfr1 signaling", "Regulation of tp53 activity", "Regulation of tp53 activity through acetylation", "Regulation of tp53 activity through association with co factors", "Regulation of tp53 activity through methylation", "Regulation of tp53 activity through phosphorylation", "Regulation of tp53 expression and degradation", "Release of apoptotic factors from the mitochondria", "Release of hh np from the secreting cell", "Repression of wnt target genes", "Reproduction", "Resolution of abasic sites ap sites", "Resolution of ap sites via the multiple nucleotide patch replacement pathway", "Resolution of d loop structures", "Resolution of d loop structures through synthesis dependent strand annealing sdsa", "Resolution of sister chromatid cohesion", "Respiratory electron transport", "Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins", "Response of eif2ak1 hri to heme deficiency", "Response of eif2ak4 gcn2 to amino acid deficiency", "Response of mtb to phagocytosis", "Response to elevated platelet cytosolic ca2", "Ret signaling", "Retrograde neurotrophin signalling", "Retrograde transport at the trans golgi network", "Rho gtpase cycle", "Rho gtpase effectors", "Rho gtpases activate cit", "Rho gtpases activate formins", "Rho gtpases activate iqgaps", "Rho gtpases activate ktn1", "Rho gtpases activate nadph oxidases", "Rho gtpases activate paks", "Rho gtpases activate pkns", "Rho gtpases activate rhotekin and rhophilins", "Rho gtpases activate rocks", "Rho gtpases activate wasps and waves", "Rhoa gtpase cycle", "Rhob gtpase cycle", "Rhobtb gtpase cycle", "Rhobtb1 gtpase cycle", "Rhobtb2 gtpase cycle", "Rhobtb3 atpase cycle", "Rhoc gtpase cycle", "Rhod gtpase cycle", "Rhof gtpase cycle", "Rhog gtpase cycle", "Rhoh gtpase cycle", "Rhoj gtpase cycle", "Rhoq gtpase cycle", "Rhot1 gtpase cycle", "Rhou gtpase cycle", "Rhov gtpase cycle", "Rip mediated nfkb activation via zbp1", "Ripk1 mediated regulated necrosis", "Rmts methylate histone arginines", "Rna polymerase i promoter escape", "Rna polymerase i transcription", "Rna polymerase i transcription initiation", "Rna polymerase i transcription termination", "Rna polymerase ii transcribes snrna genes", "Rna polymerase ii transcription", "Rna polymerase ii transcription termination", "Rna polymerase iii chain elongation", "Rna polymerase iii transcription", "Rna polymerase iii transcription initiation from type 1 promoter", "Rna polymerase iii transcription initiation from type 3 promoter", "Rna polymerase iii transcription termination", "Rnd1 gtpase cycle", "Rnd2 gtpase cycle", "Rnd3 gtpase cycle", "Robo receptors bind akap5", "Role of abl in robo slit signaling", "Role of lat2 ntal lab on calcium mobilization", "Role of phospholipids in phagocytosis", "Role of second messengers in netrin 1 signaling", "Rora activates gene expression", "Ros and rns production in phagocytes", "Rrna modification in the nucleus and cytosol", "Rrna processing", "Rrna processing in the mitochondrion", "Rsk activation", "Runx1 interacts with co factors whose precise effect on runx1 targets is not known", "Runx1 regulates expression of components of tight junctions", "Runx1 regulates genes involved in megakaryocyte differentiation and platelet function", "Runx1 regulates transcription of genes involved in differentiation of hscs", "Runx2 regulates bone development", "Runx2 regulates genes involved in cell migration", "Runx3 regulates cdkn1a transcription", "Runx3 regulates notch signaling", "Runx3 regulates p14 arf", "Runx3 regulates wnt signaling", "S phase", "Sars cov 1 infection", "Sars cov 2 infection", "Sars cov infections", "Scavenging by class a receptors", "Scavenging by class b receptors", "Scavenging by class f receptors", "Scf skp2 mediated degradation of p27 p21", "Sealing of the nuclear envelope ne by escrt iii", "Selective autophagy", "Selenoamino acid metabolism", "Sema3a pak dependent axon repulsion", "Sema3a plexin repulsion signaling by inhibiting integrin adhesion", "Sema4d in semaphorin signaling", "Sema4d induced cell migration and growth cone collapse", "Sema4d mediated inhibition of cell attachment and migration", "Semaphorin interactions", "Senescence associated secretory phenotype sasp", "Sensing of dna double strand breaks", "Sensory perception", "Sensory processing of sound", "Sensory processing of sound by outer hair cells of the cochlea", "Separation of sister chromatids", "Serine biosynthesis", "Shc mediated cascade fgfr1", "Shc mediated cascade fgfr3", "Shc mediated cascade fgfr4", "Shc related events triggered by igf1r", "Shc1 events in egfr signaling", "Shc1 events in erbb2 signaling", "Shc1 events in erbb4 signaling", "Sialic acid metabolism", "Signal amplification", "Signal attenuation", "Signal regulatory protein family interactions", "Signal transduction by l1", "Signaling by alk", "Signaling by alk in cancer", "Signaling by bmp", "Signaling by braf and raf1 fusions", "Signaling by csf3 g csf", "Signaling by ctnnb1 phospho site mutants", "Signaling by cytosolic fgfr1 fusion mutants", "Signaling by egfr", "Signaling by egfr in cancer", "Signaling by erbb2", "Signaling by erbb2 ecd mutants", "Signaling by erbb2 in cancer", "Signaling by erbb4", "Signaling by erythropoietin", "Signaling by fgfr", "Signaling by fgfr in disease", "Signaling by fgfr1", "Signaling by fgfr1 in disease", "Signaling by fgfr2", "Signaling by fgfr2 iiia tm", "Signaling by fgfr2 in disease", "Signaling by fgfr3", "Signaling by fgfr3 fusions in cancer", "Signaling by fgfr4", "Signaling by fgfr4 in disease", "Signaling by flt3 fusion proteins", "Signaling by flt3 itd and tkd mutants", "Signaling by gpcr", "Signaling by hedgehog", "Signaling by hippo", "Signaling by insulin receptor", "Signaling by interleukins", "Signaling by kit in disease", "Signaling by leptin", "Signaling by mapk mutants", "Signaling by met", "Signaling by moderate kinase activity braf mutants", "Signaling by mras complex mutants", "Signaling by notch", "Signaling by notch1", "Signaling by notch1 hd domain mutants in cancer", "Signaling by notch1 pest domain mutants in cancer", "Signaling by notch1 t 7 9 notch1 m1580 k2555 translocation mutant", "Signaling by notch2", "Signaling by notch3", "Signaling by notch4", "Signaling by ntrk2 trkb", "Signaling by ntrk3 trkc", "Signaling by ntrks", "Signaling by nuclear receptors", "Signaling by pdgf", "Signaling by pdgfr in disease", "Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants", "Signaling by ptk6", "Signaling by receptor tyrosine kinases", "Signaling by retinoic acid", "Signaling by rho gtpases miro gtpases and rhobtb3", "Signaling by robo receptors", "Signaling by scf kit", "Signaling by tgf beta receptor complex", "Signaling by tgfb family members", "Signaling by the b cell receptor bcr", "Signaling by type 1 insulin like growth factor 1 receptor igf1r", "Signaling by vegf", "Signaling by wnt", "Signaling by wnt in cancer", "Signalling to erks", "Signalling to ras", "Sirt1 negatively regulates rrna expression", "Slbp dependent processing of replication dependent histone pre mrnas", "Slc mediated transmembrane transport", "Slc transporter disorders", "Smac xiap regulated apoptotic response", "Smad2 smad3 smad4 heterotrimer regulates transcription", "Small interfering rna sirna biogenesis", "Smooth muscle contraction", "Snrnp assembly", "Sodium calcium exchangers", "Sos mediated signalling", "Sphingolipid de novo biosynthesis", "Sphingolipid metabolism", "Spry regulation of fgf signaling", "Srp dependent cotranslational protein targeting to membrane", "Stabilization of p53", "Stat3 nuclear events downstream of alk signaling", "Stat5 activation", "Stat5 activation downstream of flt3 itd mutants", "Stimuli sensing channels", "Sting mediated induction of host immune responses", "Striated muscle contraction", "Sulfide oxidation to sulfate", "Sulfur amino acid metabolism", "Sumo is conjugated to e1 uba2 sae1", "Sumo is transferred from e1 to e2 ube2i ubc9", "Sumoylation", "Sumoylation of chromatin organization proteins", "Sumoylation of dna damage response and repair proteins", "Sumoylation of dna methylation proteins", "Sumoylation of dna replication proteins", "Sumoylation of rna binding proteins", "Sumoylation of sumoylation proteins", "Sumoylation of transcription cofactors", "Sumoylation of transcription factors", "Sumoylation of ubiquitinylation proteins", "Suppression of apoptosis", "Suppression of phagosomal maturation", "Surfactant metabolism", "Switching of origins to a post replicative state", "Synaptic adhesion like molecules", "Syndecan interactions", "Synthesis of 5 eicosatetraenoic acids", "Synthesis of active ubiquitin roles of e1 and e2 enzymes", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol", "Synthesis of diphthamide eef2", "Synthesis of dna", "Synthesis of gdp mannose", "Synthesis of ip2 ip and ins in the cytosol", "Synthesis of ketone bodies", "Synthesis of leukotrienes lt and eoxins ex", "Synthesis of lipoxins lx", "Synthesis of pa", "Synthesis of pc", "Synthesis of pe", "Synthesis of pg", "Synthesis of pi", "Synthesis of pips at the er membrane", "Synthesis of pips at the golgi membrane", "Synthesis of pips at the plasma membrane", "Synthesis of prostaglandins pg and thromboxanes tx", "Synthesis of pyrophosphates in the cytosol", "Synthesis of substrates in n glycan biosythesis", "Synthesis of udp n acetyl glucosamine", "Synthesis of very long chain fatty acyl coas", "Synthesis secretion and deacylation of ghrelin", "Synthesis secretion and inactivation of glucagon like peptide 1 glp 1", "Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip", "Tak1 activates nfkb by phosphorylation and activation of ikks complex", "Tbc rabgaps", "Tcf dependent signaling in response to wnt", "Tcr signaling", "Telomere c strand lagging strand synthesis", "Telomere c strand synthesis initiation", "Telomere extension by telomerase", "Telomere maintenance", "Termination of translesion dna synthesis", "Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation", "Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation", "Tgf beta receptor signaling activates smads", "Tgf beta receptor signaling in emt epithelial to mesenchymal transition", "The activation of arylsulfatases", "The canonical retinoid cycle in rods twilight vision", "The citric acid tca cycle and respiratory electron transport", "The nlrp3 inflammasome", "The phototransduction cascade", "The role of gtse1 in g2 m progression after g2 checkpoint", "The role of nef in hiv 1 replication and disease pathogenesis", "Thrombin signalling through proteinase activated receptors pars", "Thromboxane signalling through tp receptor", "Ticam1 rip1 mediated ikk complex recruitment", "Tie2 signaling", "Tight junction interactions", "Tlr3 mediated ticam1 dependent programmed cell death", "Tnf signaling", "Tnfr1 induced nfkappab signaling pathway", "Tnfr1 induced proapoptotic signaling", "Tnfr1 mediated ceramide production", "Tnfr2 non canonical nf kb pathway", "Toll like receptor 9 tlr9 cascade", "Toll like receptor cascades", "Toll like receptor tlr1 tlr2 cascade", "Tp53 regulates metabolic genes", "Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "Tp53 regulates transcription of caspase activators and caspases", "Tp53 regulates transcription of cell cycle genes", "Tp53 regulates transcription of cell death genes", "Tp53 regulates transcription of death receptors and ligands", "Tp53 regulates transcription of dna repair genes", "Tp53 regulates transcription of genes involved in cytochrome c release", "Tp53 regulates transcription of genes involved in g1 cell cycle arrest", "Tp53 regulates transcription of genes involved in g2 cell cycle arrest", "Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain", "Traf3 dependent irf activation pathway", "Traf6 mediated irf7 activation", "Traf6 mediated irf7 activation in tlr7 8 or 9 signaling", "Traf6 mediated nf kb activation", "Trafficking and processing of endosomal tlr", "Trafficking of ampa receptors", "Trafficking of glur2 containing ampa receptors", "Trafficking of myristoylated proteins to the cilium", "Trans golgi network vesicle budding", "Transcription coupled nucleotide excision repair tc ner", "Transcription of e2f targets under negative control by dream complex", "Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1", "Transcription of the hiv genome", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activity of smad2 smad3 smad4 heterotrimer", "Transcriptional regulation by e2f6", "Transcriptional regulation by mecp2", "Transcriptional regulation by runx1", "Transcriptional regulation by runx2", "Transcriptional regulation by runx3", "Transcriptional regulation by small rnas", "Transcriptional regulation by the ap 2 tfap2 family of transcription factors", "Transcriptional regulation by tp53", "Transcriptional regulation by ventx", "Transcriptional regulation of granulopoiesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation of white adipocyte differentiation", "Transferrin endocytosis and recycling", "Translation", "Translation of replicase and assembly of the replication transcription complex", "Translation of sars cov 1 structural proteins", "Translation of sars cov 2 structural proteins", "Translesion synthesis by polh", "Translesion synthesis by polk", "Translesion synthesis by y family dna polymerases bypasses lesions on dna template", "Translocation of slc2a4 glut4 to the plasma membrane", "Transmission across chemical synapses", "Transport and synthesis of paps", "Transport of bile salts and organic acids metal ions and amine compounds", "Transport of connexons to the plasma membrane", "Transport of fatty acids", "Transport of inorganic cations anions and amino acids oligopeptides", "Transport of mature mrnas derived from intronless transcripts", "Transport of mature transcript to cytoplasm", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "Transport of nucleotide sugars", "Transport of small molecules", "Transport of the slbp dependant mature mrna", "Transport of vitamins nucleosides and related molecules", "Transport to the golgi and subsequent modification", "Trif mediated programmed cell death", "Triglyceride catabolism", "Triglyceride metabolism", "Tristetraprolin ttp zfp36 binds and destabilizes mrna", "Trna aminoacylation", "Trna modification in the mitochondrion", "Trna modification in the nucleus and cytosol", "Trna processing", "Trna processing in the mitochondrion", "Trna processing in the nucleus", "Trp channels", "Tryptophan catabolism", "Type i hemidesmosome assembly", "Tyrosine catabolism", "Tysnd1 cleaves peroxisomal proteins", "Ub specific processing proteases", "Uch proteinases", "Unblocking of nmda receptors glutamate binding and activation", "Unfolded protein response upr", "Unwinding of dna", "Uptake and actions of bacterial toxins", "Uptake and function of anthrax toxins", "Uptake and function of diphtheria toxin", "Urea cycle", "Vasopressin regulates renal water homeostasis via aquaporins", "Vegfr2 mediated cell proliferation", "Vegfr2 mediated vascular permeability", "Vesicle mediated transport", "Viral messenger rna synthesis", "Visual phototransduction", "Vitamin b1 thiamin metabolism", "Vitamin b2 riboflavin metabolism", "Vitamin b5 pantothenate metabolism", "Vitamin c ascorbate metabolism", "Vitamin d calciferol metabolism", "Vldl assembly", "Vldlr internalisation and degradation", "Vxpx cargo targeting to cilium", "Wax and plasmalogen biosynthesis", "Wnt ligand biogenesis and trafficking", "Wnt mediated activation of dvl", "Wnt5a dependent internalization of fzd2 fzd5 and ror2", "Wnt5a dependent internalization of fzd4", "Zbp1 dai mediated induction of type i ifns"], "available_proteins": ["AAAS", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADAM17", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANLN", "ANXA1", "ANXA2", "ANXA6", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3M1", "AP3S1", "APEH", "APEX1", "APLP2", "APOO", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARMCX3", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD3B", "ATG4B", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "B4GAT1", "BABAM1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BRCA1", "BRD2", "BSG", "BUB1B", "BUB3", "BUD23", "BYSL", "C19orf70", "C1QBP", "C1orf35", "CAD", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD3EAP", "CDC23", "CDC27", "CDC34", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CENPI", "CERS2", "CFL1", "CHAF1B", "CHAMP1", "CHCHD3", "CHD4", "CHERP", "CHID1", "CHKA", "CHMP3", "CHMP7", "CHORDC1", "CHST14", "CHTF18", "CIAPIN1", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLINT1", "CLNS1A", "CLTC", "CMAS", "CMPK1", "CNDP2", "CNN2", "CNOT1", "CNOT10", "CNOT3", "CNOT6", "CNOT7", "CNOT9", "COG7", "COLGALT1", "COMMD2", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CRKL", "CRNKL1", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CWC15", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DCAF13", "DCAF7", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDB1", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX52", "DDX56", "DDX6", "DEK", "DERL1", "DFFA", "DGCR8", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHX15", "DHX16", "DHX36", "DHX37", "DHX38", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DPH2", "DPM1", "DPYSL2", "DSG2", "DSP", "DST", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI2", "ECSIT", "EDC3", "EDC4", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFTUD2", "EHD1", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELOA", "ELOB", "ELP1", "ELP2", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "ENSA", "ENY2", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERCC2", "ERCC3", "ERCC6L", "ERLIN2", "ERO1A", "ERP44", "ESD", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "F11R", "FADS2", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120B", "FAM49B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FDFT1", "FDPS", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP14", "FKBP4", "FKBP5", "FKBP8", "FLAD1", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FN3KRP", "FNTB", "FOXK1", "FSCN1", "FTO", "FTSJ3", "FUCA2", "FUS", "FXR1", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GINS1", "GINS4", "GLA", "GLB1", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLUD1", "GM2A", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNL3", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLGB1", "GOLIM4", "GORASP2", "GOT1", "GOT2", "GPAA1", "GPD2", "GPI", "GPS1", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP3", "GUSB", "GYS1", "H1F0", "H2AFX", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAUS5", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HEBP1", "HECTD1", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIF1AN", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HPRT1", "HSD17B10", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IGF2BP1", "IGF2BP3", "IGF2R", "ILF2", "ILK", "IMMT", "IMP3", "IMPDH2", "INCENP", "INTS11", "INTS14", "INTS3", "IPO5", "IPO8", "IPO9", "IQGAP1", "IRS4", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0391", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KLC2", "KLC4", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMP1", "LAMTOR1", "LAMTOR2", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3BP", "LGMN", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LNPEP", "LPCAT1", "LRPPRC", "LRRC1", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LTV1", "LYPLA1", "MAGED2", "MAGT1", "MAP2K1", "MAPRE1", "MARC1", "MARCKS", "MARS", "MAT2A", "MAU2", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDC1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED16", "METAP2", "MFN1", "MFN2", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINPP1", "MLEC", "MMAB", "MMGT1", "MMS19", "MOGS", "MORF4L1", "MOV10", "MPHOSPH10", "MPI", "MPP2", "MPRIP", "MPST", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTR", "MTX1", "MTX2", "MYBBP1A", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1C", "MYO6", "NAA35", "NADK2", "NAGK", "NAGLU", "NAMPT", "NANS", "NAPA", "NAPG", "NARS", "NAT10", "NAXE", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCSTN", "NDC1", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFAF7", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4L", "NEFL", "NEK9", "NELFCD", "NEU1", "NHLRC2", "NHP2", "NIP7", "NIPBL", "NISCH", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC4L", "NOL11", "NOL6", "NOL9", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NPTN", "NRBP1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NT5C2", "NT5C3B", "NUB1", "NUBP2", "NUCB1", "NUDC", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NXF1", "OAT", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OSBP", "OSBPL11", "OSBPL6", "OSBPL9", "OTUB1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK2", "PAK4", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCM1", "PCMT1", "PCNA", "PDCD11", "PDCD4", "PDCD6", "PDCD6IP", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA6", "PDK3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PEBP1", "PECR", "PELP1", "PES1", "PEX14", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIGS", "PIGT", "PIR", "PISD", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PMPCA", "PMPCB", "PNO1", "PNP", "PNPLA6", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPID", "PPIH", "PPIL1", "PPIL4", "PPME1", "PPP1CA", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PPP6R3", "PPT1", "PQBP1", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF6", "PRPF8", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PTBP1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPN1", "PTRH2", "PUF60", "PUS1", "PUS7", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RABGGTA", "RAC1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAD51AP1", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP9", "RANGAP1", "RARS", "RARS2", "RBBP6", "RBM14", "RBM17", "RBM22", "RBM28", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCOR1", "RDH11", "RDH13", "RDX", "REPS1", "RETSAT", "REXO2", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIF1", "RINT1", "RIOK2", "RIPK1", "RNASET2", "RNF114", "RNF20", "RNF40", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP7A", "RRP8", "RRP9", "RSF1", "RTCB", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SARNP", "SARS", "SARS2", "SART1", "SCAMP1", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCP2", "SCRIB", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEH1L", "SEL1L", "SENP3", "SEPT2", "SEPT7", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SGPL1", "SGTA", "SH3GL1", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A26", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35B2", "SLC3A2", "SLC6A15", "SLIT2", "SLK", "SMARCA4", "SMARCA5", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMN1*", "SMNDC1", "SMPD4", "SMYD3", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX2", "SNX3", "SNX9", "SOD2", "SORT1", "SPAG9", "SPCS2", "SPCS3", "SPEN", "SPR", "SPTAN1", "SPTBN1", 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0.0687547082162972 0.1728701573933007 1.3368036576958324 0.5554170290527195 1.9109030412897592 0.2451148181788838 8.471957845697295e-13 6.275167299951582e-11 1.578631333778629e-08 2.1037423825620157e-08 +Ebola virus infection in host 6 30 2.144330961925748 0.0320063776548569 8.91504854368932 39.1747572815534 -0.080663749264401 0.6621232918600322 4.641524978264913 4.19529830330444 0.8188218234576878 0.3110955479480203 0.0876325329480415 0.0767446240128207 0.0117065019059818 0.0254058481796187 +Glycosaminoglycan degradation 5 6 2.0995236735571163 0.0357707631872057 3.407766990291262 5.864077669902913 0.1350713234786387 0.1703873780123549 1.3379225542760151 0.7043353086258667 1.932540087143412 0.2532951180616937 2.460833692014816e-07 6.740290595720374e-10 1.632317154479711e-07 9.46401314534944e-06 +Alzheimers disease 7 69 2.0339108737165312 0.0419605824207338 18.929611650485437 83.0752427184466 0.8523996335219438 0.5089902911900335 9.09856474570077 6.061710858604258 1.0800674607776464 0.3865214102951685 0.6220079992876584 0.1263764916712773 0.1073748414971352 0.162446290784764 +Sphingolipid metabolism in senescence 4 9 1.9916471013463843 0.0464097915467021 4.349514563106796 11.679611650485436 1.1898351622318797 0.2087194733713789 1.8732078185138223 1.4259290429724831 1.4063103725171229 0.2533781048666968 0.1070183553885475 6.684645425207902e-05 0.0001958127697586 0.0006524167345181 +7oxoc and 7betahc pathways 2 7 1.982684992252533 0.0474026269917882 2.6310679611650487 9.114077669902912 0.3689449979304526 0.3795786079895399 1.6691971866165078 1.1881681559370796 1.206779545179813 0.2917372556940649 0.0027067874988798 0.0004672463302539 0.0063676045893722 0.0403506671570748 +Alzheimers disease and mirna effects 7 70 1.974763792079445 0.0482949598027406 19.78640776699029 84.62864077669903 0.8675405351918691 0.5019659822826982 9.06411947478317 6.212690980603589 1.0744065053186531 0.3869842050583563 0.6276501385631038 0.131515176686889 0.1144375788093372 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+1,130 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Inclusion body myositis 0.978376172990617 2.6336258791322864 0.008447851471536 0.9923240631780416 0.0757666678853388 2 P05067 1 +Degradation pathway of sphingolipids including diseases 0.9720785216620254 2.3140937949418765 0.0206625777177971 0.9999937602253184 0.1510444867275133 7 P06865,Q99519,P06280,P17900,P16278 5 +Drug induction of bile acid pathway 0.887392900856794 2.253573420038475 0.0242230170468569 0.999999228693601 0.1608879996220483 2 P08183 1 +Proteoglycan biosynthesis 0.8849449204406392 2.243144200684198 0.0248875171637164 0.9999994783165956 0.1608879996220483 2 Q8NCH0 1 +Ebola virus infection in host 0.6267078034914841 2.1443309619257476 0.0320063776548569 0.9999999922229896 0.1874659262641619 30 Q96AX1,Q07021,P10321,P61916,O15118,P05556 6 +Glycosaminoglycan degradation 0.9660809154066208 2.0995236735571163 0.0357707631872057 0.9999999991692128 0.1993438647520009 6 P06865,P07686,P54802,P16278,P15586 5 +Nuclear receptors in lipid metabolism and toxicity 0.8363933088535322 2.0341853707500746 0.0419329089773823 0.9999999999790464 0.2230127250879744 2 P08183 1 +Alzheimers disease 0.497396702592812 2.0339108737165312 0.0419605824207338 0.9999999999793908 0.2230127250879744 69 P05067,P60900,P49721,Q9NSK0,P67870,Q92542,P28072 7 +Sphingolipid metabolism in senescence 0.7856474182708748 1.9916471013463843 0.0464097915467021 0.9999999999985756 0.2357453128124514 9 P04062,O15269,P16278,Q13510 4 +7oxoc and 7betahc pathways 0.882030010258912 1.982684992252533 0.0474026269917882 0.9999999999992166 0.2366009382024907 7 P61916,O15118 2 +Alzheimers disease and mirna effects 0.4904404356504367 1.974763792079445 0.0482949598027406 0.9999999999995426 0.2389767838514926 70 P05067,P60900,P49721,Q9NSK0,P67870,Q92542,P28072 7 +Nanomaterial induced apoptosis 0.884419095502753 1.8037782739069157 0.0712660730754015 1.0 0.3087002235932333 4 O43464 1 +Apoptosisrelated network due to altered notch3 in ovarian cancer 0.7048621881487455 1.7905157746776674 0.0733710336152402 1.0 0.3119627651492436 12 Q13501,P05067,Q93034 3 +Congenital generalized lipodystrophy cgl 0.7796817625459047 1.78538480182717 0.0741989221290215 1.0 0.3131630978092528 2 P31751 1 +Phase i biotransformations non p450 0.8709387474011585 1.757569686213951 0.0788207550215145 1.0 0.3271868929160277 3 P38571 1 +Vitamin d metabolism 0.8703158560499566 1.755161605444833 0.0792316691904666 1.0 0.3271868929160277 3 Q9UBM7 1 +Iron metabolism in placenta 0.8674395980378069 1.744037013180728 0.0811526359515986 1.0 0.3294115962656356 3 P02786 1 +Aryl hydrocarbon receptor pathway wp2873 0.862979590423075 1.722576658785374 0.084965108974087 1.0 0.3334851490871325 4 Q15185 1 +Splicing factor nova regulated synaptic proteins 0.7104429492030524 1.7218923573965577 0.0850890196911757 1.0 0.3334851490871325 10 Q06481,Q13573 2 +Sphingolipid pathway 0.8051368613652334 1.6904805323820191 0.0909360595894277 1.0 0.3479819880288768 7 P04062,O15269,Q13510 3 +Proximal tubule transport 0.7108660099215572 1.679660816603702 0.0930233275931193 1.0 0.3500149961030851 9 P08195,P08183,O15439 3 +Copper homeostasis 0.8437628257063251 1.656808763052616 0.0975581447724636 1.0 0.3597997911248616 6 P05067 1 +Sphingolipid metabolism overview 0.8079096368629884 1.5364040951577007 0.1244393030137371 1.0 0.4226518339046458 5 O15269,Q13510 2 +Sphingolipid metabolism integrated pathway 0.8079096368629884 1.5364040951577007 0.1244393030137371 1.0 0.4226518339046458 5 O15269,Q13510 2 +Cholesterol biosynthesis with skeletal dysplasias 0.8042099122454585 1.5223565199712827 0.1279197731821799 1.0 0.4319173518033605 5 Q15392,Q9UBM7 2 +Endoderm differentiation 0.5566506882441518 1.4949069674397784 0.1349387236541157 1.0 0.4353677424443855 21 P05067 1 +Phosphoinositides metabolism 0.7135862913096738 1.4904239692561496 0.1361127939953827 1.0 0.4353677424443855 2 Q9Y217 1 +Network map of sarscov2 signaling pathway 0.5542638918077816 1.4487973159717338 0.1473941935738554 1.0 0.4489809123136495 20 Q08380,Q07021,Q658P3 3 +Development of ureteric collection system 0.7812458208711058 1.4349587385899247 0.1512988558279215 1.0 0.4570818065538262 5 O94813 1 +Sudden infant death syndrome sids susceptibility pathways 0.5260177214657188 1.3888758254434954 0.1648705127795788 1.0 0.4912977890627326 23 Q13547,P42892,P27348 3 +Mechanoregulation and pathology of yaptaz via hippo and nonhippo mechanisms 0.7439787601051182 1.2848450969591323 0.1988464197947026 1.0 0.5591632519199383 6 Q13177,P05556,P27348 3 +Apoptosis modulation by hsp70 0.74971098595454 1.2836480810813462 0.1992651182591269 1.0 0.5591632519199383 3 O95831 1 +Ferroptosis 0.5386698758177239 1.266529220451643 0.2053236747690459 1.0 0.5612180443687255 18 P08195,P02786 2 +Kennedy pathway from sphingolipids 0.7262401213578876 1.196954182363304 0.2313244136257146 1.0 0.6063023443888594 4 P35790 1 +Genes controlling nephrogenesis 0.7178364632994936 1.1867296583670386 0.2353342724920204 1.0 0.6112301919023517 6 O94813 1 +Ranklrank signaling pathway 0.7134910221762015 1.1704274559623764 0.2418289919985812 1.0 0.6163411660367122 6 Q13501,P31751 2 +Primary focal segmental glomerulosclerosis fsgs 0.5349719130720172 1.1239252832514992 0.2610447243675731 1.0 0.6419104982853061 15 Q14108,P05556 2 +Pregnane x receptor pathway 0.6969279814640565 1.1128159238930866 0.265787494930128 1.0 0.6419104982853061 5 P08183 1 +Glucocorticoid receptor pathway 0.6855803547853621 1.0696119299607825 0.2847940230145498 1.0 0.6606362829162563 5 Q15185 1 +Cannabinoid receptor signaling 0.6172990616075099 1.0586060139348354 0.2897792468882922 1.0 0.6667787839811811 2 P17612 1 +Histone modifications 0.6846055849186863 1.0369265257707836 0.2997701006646784 1.0 0.682809673736212 4 Q9H7B4,Q01105 2 +S1p receptor signal transduction 0.6733774070170406 0.9940830599963224 0.3201824317710569 1.0 0.7074596634616086 4 Q13510 1 +Caloric restriction and aging 0.6685714285714256 0.9670439094961708 0.3335220835232269 1.0 0.7161857429724967 3 P43490,P42345 2 +Methionine de novo and salvage pathway 0.6095026319199591 0.9254438916267904 0.3547350567258545 1.0 0.7264335457599407 7 Q13126 1 +Initiation of transcription and translation elongation at the hiv1 ltr 0.6530385883550072 0.9170076017157952 0.3591386567264178 1.0 0.7264335457599407 4 Q13547,Q92769 2 +Tnfrelated weak inducer of apoptosis tweak signaling pathway 0.6442147955624918 0.9122865481115632 0.3616178937366792 1.0 0.7264335457599407 6 Q13547,P31751 2 +Hepatitis b infection 0.5047828056928841 0.9010653684548072 0.3675535648592412 1.0 0.7264335457599407 13 Q15904,P27348 2 +Notch signaling 0.6407882229381 0.8996728915797091 0.3682943537684329 1.0 0.7264335457599407 6 Q92542 1 +Fluoropyrimidine activity 0.5170522153245157 0.8995884108676176 0.3683393268553354 1.0 0.7264335457599407 11 Q92820 1 +Tgfbeta signaling pathway 0.4387833533505207 0.8973267411882686 0.369544591222827 1.0 0.7264335457599407 26 Q13547,P05067,Q7Z3T8,Q13573,P05556 5 +Camkk2 pathway 0.5948068309129928 0.868617872808234 0.3850561753803654 1.0 0.7492279480282364 7 Q13501,P42345 2 +Overlap between signal transduction pathways contributing to lmna laminopathies 0.4958173419715982 0.8587563743938675 0.3904749408711674 1.0 0.7546552729294617 13 P55209,Q13547,O75844,P48729,Q9Y2U8 5 +Metastatic brain tumor 0.6346938775510168 0.8379552860563565 0.4020558166275632 1.0 0.7667110921734925 3 Q00534,P04637 2 +Breast cancer pathway 0.4697465394555309 0.8348961238629985 0.4037761973829172 1.0 0.7674421764827632 16 P67870,P48729,P31751,P38398 4 +Integrinmediated cell adhesion 0.4625475572464894 0.7982776205771537 0.4247094020447188 1.0 0.7910144902561659 16 Q13177,O96013,P17655,P31751,P05556,P62993 6 +Neural crest cell migration in cancer 0.5745525999649823 0.7910959087109304 0.428888026458079 1.0 0.7941346038288302 7 Q13177,P31751,Q99523 3 +Nsp1 from sarscov2 inhibits translation initiation in the host cell 0.4772742050694676 0.7718805421533872 0.4401851827185945 1.0 0.8028953787310283 13 O75822,P55010,O15372,O75821,P20042 5 +Nephrotic syndrome 0.4806899256568067 0.7376158190687868 0.4607479397736151 1.0 0.8130072261470442 11 Q9Y5K6,Q14108,Q9NQW6,O75844 4 +Translation factors 0.3979305277918616 0.7359801467677971 0.4617427800068578 1.0 0.8130072261470442 36 Q04637,Q05639,Q15056,O75822,O75153,P55010,O75821,O15372,P20042,P63241,Q9NR50 11 +Sarscov2 innate immunity evasion and cellspecific immune response 0.5199398084114487 0.714732212916186 0.4747745288615279 1.0 0.8162631711437284 8 P35613,Q13546 2 +Mesodermal commitment pathway 0.4237057028310351 0.6494274314231644 0.5160621380717401 1.0 0.8468581694407401 18 Q07021 1 +Fragile x syndrome 0.3927588878106695 0.6263188120556017 0.531105849691512 1.0 0.8468581694407401 30 Q04637,P05067,Q9NZ01,Q06787,P42345,P28288,Q15334,Q96CW1,P62993 9 +Notch signaling pathway 0.4491497412208611 0.6202792696355468 0.53507394068754 1.0 0.8468581694407401 12 Q92542,Q13573 2 +Allograft rejection 0.5284795575325935 0.6198203689121033 0.535376056869127 1.0 0.8468581694407401 7 P10321,P01889 2 +Influence of laminopathies on wnt signaling 0.4634564768703641 0.619461618845782 0.5356122989664538 1.0 0.8468581694407401 9 Q5JTV8,P48729,P50402,O75844 4 +Ciliary landscape 0.3458555339485442 0.6064635859503235 0.5442069557596028 1.0 0.8488445451250326 83 P06280,P10619,P16278 3 +Folatealcohol and cancer pathway hypotheses 0.5063239494084051 0.588697296740203 0.5560643516337564 1.0 0.8521817404463325 2 P11766 1 +Proteasome degradation 0.3664700094672757 0.5877967137159718 0.5566687501128267 1.0 0.8521817404463325 41 P10321,P28072,P60900,P49721 4 +Insulin signaling in adipocytes diabetic condition 0.5614322012012087 0.5853255774791694 0.55832881974978 1.0 0.8521817404463325 4 P31751,P42345 2 +Insulin signaling in adipocytes normal condition 0.5614322012012087 0.5853255774791694 0.55832881974978 1.0 0.8521817404463325 4 P31751,P42345 2 +Chromosomal and 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Q9Y624,Q9UDY2 2 +Cellular proteostasis 0.5213827003413534 0.4539503373610861 0.6498645719530374 1.0 0.9187740500025702 4 Q99471 1 +Pancreatic adenocarcinoma pathway 0.3971309504367156 0.4332194531034225 0.664855347759886 1.0 0.930308577960987 14 P11233,Q13177,P31751,P42345 4 +Cholesterol metabolism with bloch and kandutschrussell pathways 0.3800095770524019 0.4288772697609433 0.6680125427078483 1.0 0.930677668724041 18 Q15392,Q9UBM7 2 +Monoamine transport 0.510748435543586 0.4096577982012435 0.6820569918397088 1.0 0.935033082505946 3 O15127 1 +Urea cycle and related diseases 0.4483884128926966 0.3792218548720636 0.7045231236678473 1.0 0.9428404713745688 2 Q9UJS0 1 +Erbb signaling pathway 0.3876864720949239 0.3550778764935113 0.7225312501525032 1.0 0.9439035272998368 11 O96013,Q13177,P31751,P42345 4 +Calcium regulation in cardiac cells 0.3526588181347546 0.3405388691715441 0.7334507565836161 1.0 0.9439035272998368 21 P05026,P61981,Q9Y3B8,P54709,P23634,P20020,P27348 7 +Dna mismatch repair 0.3706598403614521 0.3387872213846912 0.734770028465136 1.0 0.9439035272998368 15 Q9UQ84,P35251 2 +Ncrnas involved in wnt signaling in hepatocellular carcinoma 0.4147989613926494 0.3344518508354269 0.7380386184086556 1.0 0.9439035272998368 8 P67870 1 +Integrated cancer pathway 0.3817549970160824 0.3333366126411549 0.7388802052533394 1.0 0.9439035272998368 11 P54132 1 +Lncrna in canonical wnt signaling and colorectal cancer 0.3790444108788811 0.3235468711046628 0.7462811166279963 1.0 0.9439035272998368 11 P67870 1 +Liver x receptor pathway 0.4247246022031796 0.3056176442235185 0.7598957847293426 1.0 0.9439035272998368 2 O00767 1 +Tnfalpha signaling pathway 0.3694835284320445 0.2971618385245439 0.766342955027588 1.0 0.9439035272998368 12 P62993,P06737,Q13546 3 +Nrf2 pathway 0.3483549872820281 0.2958304328118937 0.7673595806316005 1.0 0.9439035272998368 19 Q9H2J7 1 +Focal adhesion 0.337807210625963 0.2919687319287905 0.7703105311471581 1.0 0.9439035272998368 25 Q13177,O96013,P17655,P31751,P05556,P62993,Q14315 7 +Praderwilli and angelman syndrome 0.4544340008173336 0.2886062931026659 0.77288267914795 1.0 0.9439035272998368 6 O95714,Q00534,Q15154,P04637,P11802 5 +Vitamin d receptor pathway 0.3982710844832166 0.2837655714541629 0.7765900403883179 1.0 0.9464175863755722 8 P08183,P49427 2 +Complement system 0.3625638235439314 0.2536698375725748 0.799750638118959 1.0 0.9586250123804194 9 Q07021 1 +Unfolded protein response 0.4477551020408125 0.2409337328235764 0.8096064770976055 1.0 0.9641371739710074 3 P05198,P04637 2 +Nonsmall cell lung cancer 0.3794331815880283 0.2302006869495586 0.8179358280828328 1.0 0.9671504164106224 8 Q9HC35 1 +Nad metabolism sirtuins and aging 0.4387755102040777 0.2207244062481833 0.8253070266745408 1.0 0.9687653032948634 3 Q00059,P43490 2 +Nad metabolism 0.4387755102040759 0.2207244062481793 0.8253070266745439 1.0 0.9687653032948634 3 Q8IXJ6,P43490 2 +Alpha 6 beta 4 signaling pathway 0.424306313848898 0.1969053930770196 0.8439015732387773 1.0 0.9733631216477192 4 P42345 1 +Nanoparticlemediated activation of receptor signaling 0.4230470496864754 0.1942913282591288 0.8459477753075864 1.0 0.9733631216477192 4 P05556 1 +Ras signaling 0.3281868080159394 0.1856291066085448 0.8527356264863264 1.0 0.9733631216477192 16 P61020,Q13177,P11233,O96013,P31751 5 +Arrhythmogenic right ventricular cardiomyopathy 0.3369333433756592 0.1848920601670912 0.8533136986942116 1.0 0.9733631216477192 11 Q14126 1 +Dopamine metabolism 0.3749490004079925 0.1795085743850316 0.8575383852974285 1.0 0.9733631216477192 2 P17612 1 +Wnt signaling 0.3347346404650616 0.1784245567450088 0.8583895652268201 1.0 0.9733631216477192 11 P67870 1 +Nad biosynthetic pathways 0.4124132298897521 0.1730425052307025 0.8626180172097091 1.0 0.9733631216477192 4 P09874,Q8IXJ6,P43490 3 +Melanoma 0.352375888930692 0.162005030754665 0.8713018922370599 1.0 0.9734413788031232 8 Q00534,P31751,P62993,P04637 4 +Small cell lung cancer 0.3691025757092203 0.148676407231667 0.881808978603839 1.0 0.9734413788031232 7 P05556 1 +Envelope proteins and their potential roles in edmd physiopathology 0.3200863206916055 0.1431126515550086 0.8862012132991886 1.0 0.9734413788031232 14 Q9Y2U8,Q14739 2 +Disruption of postsynaptic signaling by cnv 0.3631993881955613 0.136904324183372 0.8911064208185981 1.0 0.9734413788031232 7 P61981,Q07157,Q06787 3 +Intraflagellar transport proteins binding to dynein 0.3845927461030349 0.1340694130502082 0.8933476860978782 1.0 0.9734413788031232 5 Q9BW83,P63167 2 +Neural crest differentiation 0.3575778856483224 0.1261584345772513 0.8996065128149169 1.0 0.9761325866838608 7 P05556 1 +Hedgehog signaling pathway wp4249 0.3804500968669518 0.1156611886189149 0.9079210667463118 1.0 0.9767385029069832 3 P48729 1 +Cytosolic dnasensing pathway 0.3292223866626263 0.1125658798202841 0.910374737030028 1.0 0.9767385029069832 8 O14802,O15160,Q13546 3 +Vasopressinregulated water reabsorption 0.297443532772684 0.0780294722303251 0.9378046090086204 1.0 0.9950089566930648 13 P61020,Q14203,Q9UJW0,P17612,P63167 5 +Transsulfuration pathway 0.343545751633989 0.0751132783139912 0.9401245831045584 1.0 0.995630093546156 5 P23526,P25325,P26358,Q99707 4 +Gaba receptor signaling 0.3406862745098059 0.0718194608427408 0.9427455852993868 1.0 0.9965671564674918 5 O95782,P49189,Q96CW1,P63010 4 +Cardiac hypertrophic response 0.3392349901390207 0.0684209858714426 0.9454505166648646 1.0 0.997525376047682 6 P31751 1 +Nuclear receptors metapathway 0.2880555405009557 0.0509389331317299 0.959374181612072 1.0 1.0 41 Q13501,Q15185,Q12802,P08183,Q9H2J7,O00170 6 +Synaptic vesicle pathway 0.2813267813267769 0.0488222543975548 0.9610609468758828 1.0 1.0 11 P12235,P54920,P63010,O00429,P50570,O94973,Q00610,O95782,Q96CW1,P46459 10 +Metapathway biotransformation phase i and ii 0.2850544153544912 0.045114348093084 0.9640161649426752 1.0 1.0 18 Q86UY6 1 +Circadian rhythm genes 0.2894476792685338 0.0388638751151197 0.9689989182787656 1.0 1.0 36 Q13547,P54802,Q03164,Q9UNS1 4 +Burn wound healing 0.2882256745707292 0.0306804977196839 0.975524344405578 1.0 1.0 7 Q99439,P09429,P04637,P08670,P31949,P07737 6 +Factors and pathways affecting insulinlike growth factor igf1akt signaling 0.2867439799157324 0.0293518442912565 0.976583978927602 1.0 1.0 7 P05556 1 +Exerciseinduced circadian regulation 0.2762254641441873 0.027165224726956 0.9783279521116456 1.0 1.0 14 Q96PU8,P78344,Q13185,Q00577 4 +Tcell antigen receptor tcr pathway during staphylococcus aureus infection 0.2692786483006946 0.0133079845729739 0.9893820779847528 1.0 1.0 6 O95433,P62993 2 +Lipid metabolism pathway 0.2543967280163521 0.010846717875685 0.9913457409693938 1.0 1.0 8 P53396,P49327,P08559,P13861,P10644,P31751,P17612 7 +Photodynamic therapyinduced unfolded protein response 0.2340425531914875 0.0014442343874379 0.9988476680806742 1.0 1.0 9 Q9BY44,P05198,P23381,O43776,Q13217,P08243,P27797,P14625 8 +Mirna regulation of prostate cancer signaling pathways 0.2275082233310682 0.0005213561107859 0.9995840180273684 1.0 1.0 6 P42345 1 diff --git a/msigdb_wp/selections.json b/msigdb_wp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..4fae697d70b9290ed32e66a6eb4a7415526b9264 --- /dev/null +++ b/msigdb_wp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["15q112 copy number variation syndrome", "15q133 copy number variation syndrome", "16p112 distal deletion syndrome", "16p112 proximal deletion syndrome", "1q211 copy number variation syndrome", "22q112 copy number variation syndrome", "3q29 copy number variation syndrome", "4hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression", "7oxoc and 7betahc pathways", "7q1123 copy number variation syndrome", "Acetylcholine synthesis", "Acquired partial lipodystrophy barraquersimons syndrome", "Acute viral myocarditis", "Adipogenesis", "Aerobic glycolysis", "Aflatoxin b1 metabolism", "Agerage pathway", "Airway smooth muscle cell contraction", "Alanine and aspartate metabolism", "Allograft rejection", "Alpha 6 beta 4 signaling pathway", "Alternative pathway of fetal androgen synthesis", "Alzheimers disease", "Alzheimers disease and mirna effects", "Amino acid metabolism", "Amino acid metabolism pathway excerpt histidine catabolism extension", "Ampactivated protein kinase ampk signaling", "Amyotrophic lateral sclerosis als", "Androgen receptor signaling pathway", "Angiopoietinlike protein 8 regulatory pathway", "Angiotensin ii receptor type 1 pathway", "Antiviral and antiinflammatory effects of nrf2 on sarscov2 pathway", "Apoptosis", "Apoptosis modulation and signaling", "Apoptosis modulation by hsp70", "Apoptosisrelated network due to altered notch3 in ovarian cancer", "Arachidonate epoxygenase epoxide hydrolase", "Arrhythmogenic right ventricular cardiomyopathy", "Aryl hydrocarbon receptor pathway wp2586", "Aryl hydrocarbon receptor pathway wp2873", "Aspirin and mirnas", "Atm signaling in development and disease", "Atm signaling pathway", "Atr signaling", "Autophagy", "Autosomal recessive osteopetrosis pathways", "B cell receptor signaling pathway", "Base excision repair", "Bdnftrkb signaling", "Benzene metabolism", "Benzoapyrene metabolism", "Bile acids synthesis and enterohepatic circulation", "Biogenic amine synthesis", "Biomarkers for pyrimidine metabolism disorders", "Biomarkers for urea cycle disorders", "Biotin metabolism including iems", "Bladder cancer", "Bmp signaling in eyelid development", "Bmp2wnt4foxo1 pathway in primary endometrial stromal cell differentiation", "Brainderived neurotrophic factor bdnf signaling pathway", "Breast cancer pathway", "Burn wound healing", "Calcium regulation in cardiac cells", "Caloric restriction and aging", "Camkk2 pathway", "Cancer immunotherapy by pd1 blockade", "Cannabinoid receptor signaling", "Cardiac hypertrophic response", "Cardiac progenitor differentiation", "Ccl18 signaling pathway", "Cell cycle", "Cell differentiation expanded index", "Cell differentiation index", "Cell migration and invasion through p75ntr", "Cells and molecules involved in local acute inflammatory response", "Cellular proteostasis", "Cerebral organic acidurias including diseases", "Chemokine signaling pathway", "Cholesterol biosynthesis pathway", "Cholesterol biosynthesis with skeletal dysplasias", "Cholesterol metabolism with bloch and kandutschrussell pathways", "Chromosomal and microsatellite instability in colorectal cancer", "Ciliary landscape", "Ciliopathies", "Circadian rhythm genes", "Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism", "Clear cell renal cell carcinoma pathways", "Codeine and morphine metabolism", "Cohesin complex cornelia de lange syndrome", "Common pathways underlying drug addiction", "Complement and coagulation cascades", "Complement system", "Complement system in neuronal development and plasticity", "Congenital generalized lipodystrophy cgl", "Constitutive androstane receptor pathway", "Control of immune tolerance by vasoactive intestinal peptide", "Copper homeostasis", "Cori cycle", "Corticotropinreleasing hormone signaling pathway", "Cysteine and methionine catabolism", "Cytoplasmic ribosomal proteins", "Cytosine methylation", "Cytosolic dnasensing pathway", "Ddx1 as a regulatory component of the drosha microprocessor", "Degradation pathway of sphingolipids including diseases", "Deregulation of rab and rab effector genes in bladder cancer", "Development of pulmonary dendritic cells and macrophage subsets", "Development of ureteric collection system", "Disorders of folate metabolism and transport", "Disruption of postsynaptic signaling by cnv", "Dna damage response", "Dna damage response only atm dependent", "Dna irdamage and cellular response via atr", "Dna irdouble strand breaks and cellular response via atm", "Dna mismatch repair", "Dna repair pathways full network", "Dna replication", "Dopamine metabolism", "Dopaminergic neurogenesis", "Drug induction of bile acid pathway", "Dual hijack model of vif in hiv infection", "Ebola virus infection in host", "Ebsteinbarr virus lmp1 signaling", "Ectoderm differentiation", "Effect of progerin on genes involved in hutchinsongilford progeria syndrome", "Egfegfr signaling pathway", "Egfr tyrosine kinase inhibitor resistance", "Eicosanoid metabolism via cyclooxygenases cox", "Eicosanoid metabolism via lipooxygenases lox", "Eicosanoid synthesis", "Electron transport chain oxphos system in mitochondria", "Embryonic stem cell pluripotency pathways", "Endochondral ossification", "Endochondral ossification with skeletal dysplasias", "Endoderm differentiation", "Endometrial cancer", "Endoplasmic reticulum stress response in coronavirus infection", "Endothelin pathways", "Energy metabolism", "Envelope proteins and their potential roles in edmd physiopathology", "Epithelial to mesenchymal transition in colorectal cancer", "Epo receptor signaling", "Erbb signaling pathway", "Erk pathway in huntingtons disease", "Estrogen metabolism", "Estrogen receptor pathway", "Estrogen signaling pathway", "Ethanol effects on histone modifications", "Ethanol metabolism production of ros by cyp2e1", "Eukaryotic transcription initiation", "Exerciseinduced circadian regulation", "Exrna mechanism of action and biogenesis", "Extracellular vesiclemediated signaling in recipient cells", "Extracellular vesicles in the crosstalk of cardiac cells", "Factors and pathways affecting insulinlike growth factor igf1akt signaling", "Familial hyperlipidemia type 1", "Familial hyperlipidemia type 3", "Familial hyperlipidemia type 4", "Familial hyperlipidemia type 5", "Familial partial lipodystrophy fpld", "Farnesoid x receptor pathway", "Fas ligand pathway and stress induction of heat shock proteins", "Fatty acid betaoxidation", "Fatty acid biosynthesis", "Fatty acid omegaoxidation", "Fatty acid transporters", "Fbxl10 enhancement of maperk signaling in diffuse large bcell lymphoma", "Ferroptosis", "Fgfr3 signaling in chondrocyte proliferation and terminal differentiation", "Fibrin complement receptor 3 signaling pathway", "Fluoroacetic acid toxicity", "Fluoropyrimidine activity", "Focal adhesion", "Focal adhesion pi3kaktmtorsignaling pathway", "Folate metabolism", "Folatealcohol and cancer pathway hypotheses", "Follicle stimulating hormone fsh signaling pathway", "Foxa2 pathway", "Foxp3 in covid19", "Fragile x syndrome", "Fto obesity variant mechanism", "G protein signaling pathways", "G1 to s cell cycle control", "G13 signaling pathway", "Gaba metabolism aka ghb", "Gaba receptor signaling", "Gammaglutamyl cycle for the biosynthesis and degradation of glutathione including diseases", "Ganglio sphingolipid metabolism", "Gastric cancer network 1", "Gastric cancer network 2", "Gastrin signaling pathway", "Gdnfret signaling axis", "Genes controlling nephrogenesis", "Genes related to primary cilium development based on crispr", "Glial cell differentiation", "Glioblastoma signaling pathways", "Glucocorticoid receptor pathway", "Glucuronidation", "Glutathione metabolism", "Glycerolipids and glycerophospholipids", "Glycerophospholipid biosynthetic pathway", "Glycogen synthesis and degradation", "Glycolysis and gluconeogenesis", "Glycolysis in senescence", "Glycosaminoglycan degradation", "Glycosylation and related congenital defects", "Gpcrs class a rhodopsinlike", "Gpr143 in melanocytes and retinal pigment epithelium cells", "H19 action rbe2f1 signaling and cdkbetacatenin activity", "Hair follicle development cytodifferentiation part 3 of 3", "Hair follicle development organogenesis part 2 of 3", "Head and neck squamous cell carcinoma", "Heart development", "Hedgehog signaling pathway wp4249", "Hedgehog signaling pathway wp47", "Hematopoietic stem cell gene regulation by gabp alphabeta complex", "Heme biosynthesis", "Hepatitis b infection", "Hepatitis c and hepatocellular carcinoma", "Hepatocyte growth factor receptor signaling", "Hereditary leiomyomatosis and renal cell carcinoma pathway", "Hif1a and pparg regulation of glycolysis", "Hijack of ubiquitination by sarscov2", "Hippo signaling regulation pathways", "Hippomerlin signaling dysregulation", "Hippoyap signaling pathway", "Histone modifications", "Homologous recombination", "Hostpathogen interaction of human coronaviruses apoptosis", "Hostpathogen interaction of human coronaviruses autophagy", "Hostpathogen interaction of human coronaviruses interferon induction", "Hostpathogen interaction of human coronaviruses mapk signaling", "Hypertrophy model", "Hypothesized pathways in pathogenesis of cardiovascular disease", "Hypothetical craniofacial development pathway", "Id signaling pathway", "Il1 signaling pathway", "Il10 antiinflammatory signaling pathway", "Il17 signaling pathway", "Il18 signaling pathway", "Il2 signaling pathway", "Il3 signaling pathway", "Il4 signaling pathway", "Il5 signaling pathway", "Il6 signaling pathway", "Il7 signaling pathway", "Il9 signaling pathway", "Imatinib and chronic myeloid leukemia", "Immune response to tuberculosis", "Inclusion body myositis", "Influence of laminopathies on wnt signaling", "Inhibition of exosome biogenesis and secretion by manumycin a in crpc cells", "Initiation of transcription and translation elongation at the hiv1 ltr", "Insulin signaling", "Insulin signaling in adipocytes diabetic condition", "Insulin signaling in adipocytes normal condition", "Integrated cancer pathway", "Integrinmediated cell adhesion", "Interactions between immune cells and micrornas in tumor microenvironment", "Interactions between loxl4 and oxidative stress pathway", "Interactions of natural killer cells in pancreatic cancer", "Interactome of polycomb repressive complex 2 prc2", "Interferon type i signaling pathways", "Interleukin1 il1 structural pathway", "Interleukin1 induced activation of nfkb", "Interleukin11 signaling pathway", "Intracellular trafficking proteins involved in cmt neuropathy", "Intraflagellar transport proteins binding to dynein", "Irinotecan pathway", "Iron metabolism in placenta", "Joubert syndrome", "Kallmann syndrome", "Kennedy pathway from sphingolipids", "Ketogenesis and ketolysis", "Ketone bodies synthesis and degradation", "Kininkallikrein pathway", "Kisspeptinkisspeptin receptor system in the ovary", "Kit receptor signaling pathway", "Krebs cycle disorders", "Kynurenine pathway and links to cell senescence", "Leptin and adiponectin", "Leptin signaling pathway", "Leptininsulin signaling overlap", "Leukocyteintrinsic hippo pathway functions", "Linoleic acid metabolism affected by coronavirus infection", "Lipid metabolism pathway", "Liver x receptor pathway", "Lncrna in canonical wnt signaling and colorectal cancer", "Lncrnamediated mechanisms of therapeutic resistance", "Lung fibrosis", "Male infertility", "Malignant pleural mesothelioma", "Mammalian disorder of sexual development", "Mammary gland development pathway embryonic development stage 1 of 4", "Mammary gland development pathway involution stage 4 of 4", "Mammary gland development pathway pregnancy and lactation stage 3 of 4", "Mammary gland development pathway puberty stage 2 of 4", "Map3k1 role in promoting and blocking gonadal determination", "Mapk cascade", "Mapk pathway in congenital thyroid cancer", "Mapk signaling pathway", "Matrix metalloproteinases", "Mbdnf and probdnf regulation of gaba neurotransmission", "Measles virus infection", "Mechanoregulation and pathology of yaptaz via hippo and nonhippo mechanisms", "Mecp2 and associated rett syndrome", "Melanoma", "Melatonin metabolism and effects", "Mesodermal commitment pathway", "Met in type 1 papillary renal cell carcinoma", "Metabolic pathway of ldl hdl and tg including diseases", "Metabolic reprogramming in colon cancer", "Metabolism of alphalinolenic acid", "Metabolism of spingolipids in er and golgi apparatus", "Metapathway biotransformation phase i and ii", "Metastatic brain tumor", "Methionine de novo and salvage pathway", "Methionine metabolism leading to sulfur amino acids and related disorders", "Methylation pathways", "Mevalonate arm of cholesterol biosynthesis pathway", "Mevalonate pathway", "Mfap5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement", "Microglia pathogen phagocytosis pathway", "Microrna for targeting cancer growth and vascularization in glioblastoma", "Microrna network associated with chronic lymphocytic leukemia", "Micrornas in cardiomyocyte hypertrophy", "Microtubule cytoskeleton regulation", "Mir124 predicted interactions with cell cycle and differentiation", "Mir517 relationship with arcn1 and usp1", "Mirna biogenesis", "Mirna regulation of dna damage response", "Mirna regulation of p53 pathway in prostate cancer", "Mirna regulation of prostate cancer signaling pathways", "Mirnas involved in dna damage response", "Mitochondrial complex i assembly model oxphos system", "Mitochondrial complex ii assembly", "Mitochondrial complex iii assembly", "Mitochondrial complex iv assembly", "Mitochondrial fatty acid synthesis pathway", "Mitochondrial gene expression", "Mitochondrial immune response to sarscov2", "Mitochondrial long chain fatty acid betaoxidation", "Modulators of tcr signaling and t cell activation", "Monoamine transport", "Mrna processing", "Mrna protein and metabolite inducation pathway by cyclosporin a", "Mthfr deficiency", "Myd88 distinct inputoutput pathway", "Myometrial relaxation and contraction pathways", "Nad biosynthetic pathways", "Nad metabolism", "Nad metabolism in oncogeneinduced senescence and mitochondrial dysfunctionassociated senescence", "Nad metabolism sirtuins and aging", "Nanomaterial induced apoptosis", "Nanoparticle triggered autophagic cell death", "Nanoparticle triggered regulated necrosis", "Nanoparticlemediated activation of receptor signaling", "Ncrnas involved in stat3 signaling in hepatocellular carcinoma", "Ncrnas involved in wnt signaling in hepatocellular carcinoma", "Nephrogenesis", "Nephrotic syndrome", "Netrinunc5b signaling pathway", "Network map of sarscov2 signaling pathway", "Neural crest cell migration during development", "Neural crest cell migration in cancer", "Neural crest differentiation", "Neurodegeneration with brain iron accumulation nbia subtypes pathway", "Neuroinflammation", "Neuroinflammation and glutamatergic signaling", "Nicotine effect on dopaminergic neurons", "Nipbl role in dna damage cornelia de lange syndrome", "Nitric oxide metabolism in cystic fibrosis", "Nocgmppkg mediated neuroprotection", "Nonalcoholic fatty liver disease", "Nongenomic actions of 125 dihydroxyvitamin d3", "Nonhomologous end joining", "Nonsmall cell lung cancer", "Notch signaling", "Notch signaling pathway", "Notch1 regulation of endothelial cell calcification", "Novel intracellular components of rigilike receptor rlr pathway", "Nrf2 pathway", "Nrf2are regulation", "Nrp1triggered signaling pathways in pancreatic cancer", "Nsp1 from sarscov2 inhibits translation initiation in the host cell", "Nuclear receptors in lipid metabolism and toxicity", "Nuclear receptors metapathway", "Nucleotide excision repair", "Nucleotide excision repair in xeroderma pigmentosum", "Nucleotide metabolism", "Nucleotidebinding oligomerization domain nod pathway", "Oligodendrocyte specification and differentiation leading to myelin components for cns", "Omega3 omega6 fatty acid synthesis", "Omega9 fatty acid synthesis", "Oncostatin m signaling pathway", "Onecarbon metabolism", "Onecarbon metabolism and related pathways", "Orexin receptor pathway", "Osteoblast differentiation and related diseases", "Osteoclast signaling", "Osteopontin signaling", "Osx and mirnas in tooth development", "Ovarian infertility", "Overlap between signal transduction pathways contributing to lmna laminopathies", "Overview of nanoparticle effects", "Oxidation by cytochrome p450", "Oxidative damage response", "Oxidative phosphorylation", "Oxidative stress response", "Oxysterols derived from cholesterol", "P38 mapk signaling pathway", "P53 transcriptional gene network", "Pancreatic adenocarcinoma pathway", "Parkinsons disease pathway", "Parkinubiquitin proteasomal system pathway", "Pathogenesis of sarscov2 mediated by nsp9nsp10 complex", "Pathogenic escherichia coli infection", "Pathways affected in adenoid cystic carcinoma", "Pathways of nucleic acid metabolism and innate immune sensing", "Pdgf pathway", "Pdgfrbeta pathway", "Pentose phosphate metabolism", "Pentose phosphate pathway in senescent cells", "Peptide gpcrs", "Peroxiredoxin 2 induced ovarian failure", "Phase i biotransformations non p450", "Phosphodiesterases in neuronal function", "Phosphoinositides metabolism", "Photodynamic therapyinduced ap1 survival signaling", "Photodynamic therapyinduced hif1 survival signaling", "Photodynamic therapyinduced nfe2l2 nrf2 survival signaling", "Photodynamic therapyinduced unfolded protein response", "Physicochemical features and toxicityassociated pathways", "Physiological and pathological hypertrophy of the heart", "Pi3kakt signaling pathway", "Pi3kaktmtor signaling pathway and therapeutic opportunities", "Pi3kaktmtor vitd3 signaling", "Pilocytic astrocytoma", "Pkcgamma calcium signaling pathway in ataxia", "Ppar signaling pathway", "Pparalpha pathway", "Praderwilli and angelman syndrome", "Pregnane x receptor pathway", "Preimplantation embryo", "Primary focal segmental glomerulosclerosis fsgs", "Prion disease pathway", "Progeriaassociated lipodystrophy", "Prolactin signaling pathway", "Prostaglandin and leukotriene metabolism in senescence", "Prostaglandin synthesis and regulation", "Proteasome degradation", "Proteoglycan biosynthesis", "Proximal tubule transport", "Ptf1a related regulatory pathway", "Purine metabolism", "Purine metabolism and related disorders", "Purinergic signaling", "Pyrimidine metabolism", "Pyrimidine metabolism and related diseases", "Quercetin and nfkb ap1 induced apoptosis", "Rac1pak1p38mmp2 pathway", "Rala downstream regulated genes", "Ranklrank signaling pathway", "Ras and bradykinin pathways in covid19", "Ras signaling", "Regucalcin in proximal tubule epithelial kidney cells", "Regulation of actin cytoskeleton", "Regulation of apoptosis by parathyroid hormonerelated protein", "Regulation of sister chromatid separation at the metaphaseanaphase transition", "Regulation of wnt bcatenin signaling by small molecule compounds", "Regulatory circuits of the stat3 signaling pathway", "Relationship between inflammation cox2 and egfr", "Reninangiotensinaldosterone system raas", "Resistin as a regulator of inflammation", "Retinoblastoma gene in cancer", "Rett syndrome causing genes", "Riboflavin and coq disorders", "Robo4 and vegf signaling pathways crosstalk", "S1p receptor signal transduction", "Sarscov2 and covid19 pathway", "Sarscov2 b117 variant antagonises innate immune activation", "Sarscov2 innate immunity evasion and cellspecific immune response", "Selective expression of chemokine receptors during tcell polarization", "Selenium micronutrient network", "Serine metabolism", "Serotonin and anxiety", "Serotonin htr1 group and fos pathway", "Serotonin receptor 2 and elksrfgata4 signaling", "Serotonin receptor 467 and nr3c signaling", "Serotonin transporter activity", "Signal transduction through il1r", "Sleep regulation", "Small cell lung cancer", "Smc1smc3 role in dna damage cornelia de lange syndrome", "Somatroph axis gh and its relationship to dietary restriction and aging", "Sphingolipid metabolism in senescence", "Sphingolipid metabolism integrated pathway", "Sphingolipid metabolism overview", "Sphingolipid pathway", "Spinal cord injury", "Splicing factor nova regulated synaptic proteins", "Srebf and mir33 in cholesterol and lipid homeostasis", "Srf and mirs in smooth muscle differentiation and proliferation", "Statin inhibition of cholesterol production", "Steroid biosynthesis", "Sterol regulatory elementbinding proteins srebp signaling", "Striated muscle contraction pathway", "Sudden infant death syndrome sids susceptibility pathways", "Sulfation biotransformation reaction", "Supression of hmgb1 mediated inflammation by thbd", "Synaptic signaling pathways associated with autism spectrum disorder", "Synaptic vesicle pathway", "T cell receptor and costimulatory signaling", "Target of rapamycin tor signaling", "Tca cycle aka krebs or citric acid cycle", "Tca cycle and deficiency of pyruvate dehydrogenase complex pdhc", "Tca cycle in senescence", "Tca cycle nutrient use and invasiveness of ovarian cancer", "Tcell activation sarscov2", "Tcell antigen receptor tcr pathway during staphylococcus aureus infection", "Tcell receptor tcr signaling pathway", "Tgfbeta receptor signaling", "Tgfbeta receptor signaling in skeletal dysplasias", "Tgfbeta signaling in thyroid cells for epithelialmesenchymal transition", "Tgfbeta signaling pathway", "Thermogenesis", "Thiamine metabolic pathways", "Thymic stromal lymphopoietin tslp signaling pathway", "Thyroid hormones production and peripheral downstream signaling effects", "Thyroid stimulating hormone tsh signaling pathway", "Tlr4 signaling and tolerance", "Tnfalpha signaling pathway", "Tnfrelated weak inducer of apoptosis tweak signaling pathway", "Tolllike receptor signaling pathway", "Tolllike receptor signaling related to myd88", "Tp53 network", "Transcription cofactors ski and skil protein partners", "Transcription factors regulate mirnas related to cardiac hypertrophy", "Transcriptional activation by nrf2 in response to phytochemicals", "Translation factors", "Translation inhibitors in chronically activated pdgfra cells", "Transsulfuration and onecarbon metabolism", "Transsulfuration pathway", "Triacylglyceride synthesis", "Tryptophan catabolism leading to nad production", "Tryptophan metabolism", "Tumor suppressor activity of smarcb1", "Type 2 papillary renal cell carcinoma", "Type i collagen synthesis in the context of osteogenesis imperfecta", "Type i interferon induction and signaling during sarscov2 infection", "Type ii diabetes mellitus", "Type ii interferon signaling ifng", "Tyrobp causal network in microglia", "Ultraconserved region 339 modulation of tumor suppressor micrornas in cancer", "Unfolded protein response", "Urea cycle and associated pathways", "Urea cycle and metabolism of amino groups", "Urea cycle and related diseases", "Valproic acid pathway", "Vasopressinregulated water reabsorption", "Vegfavegfr2 signaling pathway", "Vitamin a and carotenoid metabolism", "Vitamin b12 disorders", "Vitamin b12 metabolism", "Vitamin b6dependent and responsive disorders", "Vitamin d metabolism", "Vitamin d receptor pathway", "Vitamin dsensitive calcium signaling in depression", "White fat cell differentiation", "Wnt signaling", "Wnt signaling in kidney disease", "Wnt signaling pathway", "Wnt signaling pathway and pluripotency", "Wntbetacatenin signaling pathway in leukemia"], "available_proteins": ["AARS", "AASS", "ABCB1", "ABCC4", "ABCD3", "ABCF1", "ABCF2", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR2", "ACTR3", "ADAM17", "ADAR", "ADH5", "ADI1", "ADK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AKAP1", "AKAP12", "AKAP13", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "AMOT", "ANAPC1", "ANAPC5", "ANAPC7", "ANK3", "ANLN", "ANXA1", "ANXA2", "ANXA6", "AP1G1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "APEX1", "APLP2", "APMAP", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH2", "ARL2", "ARL3", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ATIC", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0D1", "ATP6V1A", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATPIF1", "ATXN10", "ATXN2L", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAT2", "BCL2L12", "BCLAF1", "BLM", "BLVRA", "BPTF", "BRCA1", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "C15orf39", "C1QBP", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAND1", "CAP1", "CAPN1", "CAPN2", "CAPZB", "CARM1", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR2", "CCDC124", "CCDC6", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CDC23", "CDC27", "CDC34", "CDC37", "CDC42", "CDC73", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CEBPZ", "CECR2", "CELF1", "CENPB", "CEP170", "CERS2", "CFL1", "CFL2", "CHAMP1", "CHD4", "CHKA", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIP2A", "CKB", "CLASP1", "CLASP2", "CLIC1", "CLTC", "CLUH", "CMPK1", "CNN2", "CNOT1", "CNOT10", "CNOT6", "CNOT9", "CNP", "COA3", "COLGALT1", "COMT", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPT2", "CRKL", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DARS", "DBNL", "DCAF7", "DCTN1", "DCTN2", "DCTN4", "DCTPP1", "DDB1", "DDOST", "DDX1", "DDX17", "DDX20", "DDX21", "DDX3X", "DDX5", "DDX52", "DDX56", "DEK", "DERL1", "DFFA", "DGCR8", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX29", "DHX36", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJB1", "DNAJC3", "DNAJC7", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DPF2", "DPM1", "DPP9", "DPYSL2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "ECE1", "ECH1", "ECHS1", "ECSIT", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF4A1", "EIF4A2", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "EMD", "EML4", "ENAH", "ENO1", "EPB41", "EPB41L2", "EPHX1", "EPRS", "ERCC2", "ERCC3", "ESD", "ETF1", "ETFA", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC7", "EXOSC7", "EZR", "F11R", "FADS2", "FAF1", "FAH", "FANCI", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FECH", "FEN1", "FGFR1OP", "FH", "FHL1", "FKBP10", "FKBP2", "FKBP4", "FKBP5", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FOXC1", "FSCN1", "FTO", "FUS", "FXR1", "FXR2", "G3BP1", "G6PD", "GALNT1", "GAPDH", "GART", "GBA", "GCC2", "GCDH", "GDI1", "GFPT1", "GGCT", "GGCX", "GGH", "GIGYF2", "GLA", "GLB1", "GLS", "GLUD1", "GM2A", "GNA13", "GNAI2", "GNAI3", "GNPAT", "GNS", "GOT1", "GOT2", "GPD2", "GPI", "GPS1", "GRB2", "GRSF1", "GSK3A", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2I", "GTPBP4", "GUSB", "GYS1", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HADH", "HADHA", "HADHB", "HAT1", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HEBP1", "HELLS", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIF1AN", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMGCS1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HPRT1", "HSD17B10", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HTRA2", "HTT", "HYOU1", "IARS", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP3", "ILF2", "ILK", "IMP3", "IMPDH2", "INF2", "IPO9", "IQGAP1", "IRS4", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIF22", "KIF23", "KIF2C", "KIF4A", "KIF5B", "KLC2", "KLC4", "KMT2A", "KPNA1", "KPNA4", "KPNB1", "KTN1", "L2HGDH", "LARP1", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LEMD3", "LGALS3BP", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LRPPRC", "LRRC59", "LRWD1", "LSM2", "LSS", "LTA4H", "LUC7L", "MACF1", "MAGT1", "MAP1B", "MAP2K1", "MAP4", "MAPRE1", "MAPRE2", "MARCKS", "MARK2", "MARS", "MAT2A", "MAU2", "MBD3", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDC1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MFN2", "MGST2", "MGST3", "MIA3", "MIF", "MKI67", "MMAB", "MOGS", "MORF4L1", "MOV10", "MPI", "MPP2", "MPST", "MRE11", "MRI1", "MRPL19", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR6", "MTOR", "MTR", "MYBBP1A", "MYEF2", "MYH10", "MYH9", "MYL6", "MYO1C", "MYO6", "NAA15", "NAA40", "NAA50", "NAGLU", "NAMPT", "NAP1L1", "NAPA", "NARS", "NAT10", "NCAPG", "NCBP1", "NCKAP1", "NCL", "NCSTN", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFAF7", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFCD", "NEU1", "NIPBL", "NKRF", "NME1", "NONO", "NOP2", "NPC1", "NPC2", "NSDHL", "NSF", "NUDC", "NUDT21", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP214", "NUP62", "NUP88", "NUP98", "NXF1", "OAT", "OCLN", "OGDH", "OGT", "OPA1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PAICS", "PAK2", "PAK4", "PAPOLA", "PAPSS1", "PARK7", "PARN", "PARP1", "PARP2", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCM1", "PCNA", "PDCD4", "PDCD6", "PDCD6IP", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA6", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PEBP1", "PECR", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF6", "PHGDH", "PIGT", "PISD", "PKM", "PKN2", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PMPCA", "PNP", "PNPT1", "POLD1", "POLDIP2", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POR", "PPAT", "PPIB", "PPID", "PPIF", "PPM1G", "PPP1CA", "PPP1R10", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PRCC", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PRIM1", "PRIM2", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF3", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSPC1", "PTBP1", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTRH2", "PURA", "PUS1", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QKI", "RAB10", "RAB13", "RAB14", "RAB2A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RAC1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RALA", "RAN", "RANBP1", "RANBP9", "RANGAP1", "RARS", "RBM14", "RBM17", "RBM39", "RBM4", "RBM5", "RBMX", "RCC1", "RCN1", "RDX", "RECQL", "RECQL5", "RETSAT", "REXO2", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RIF1", "RIPK1", "RNASEH2A", "RNASET2", "RNF20", "RNF40", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RTCB", "RTN3", "RTN4", "RUVBL1", "S100A10", "S100A11", "SACM1L", "SAFB", "SAMHD1", "SAP18", "SAR1A", "SARS", "SCAMP2", "SCARB1", "SCARB2", "SCD", "SCO1", "SCP2", "SCRIB", "SDHA", "SDHB", "SEC23A", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEL1L", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SEZ6L2", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SFPQ", "SFSWAP", "SGPL1", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SIN3A", "SIRT2", "SKP1", "SKP2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35B2", "SLC3A2", "SLC6A15", "SLIT2", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMYD3", "SNAP29", "SND1", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SOD2", "SORT1", "SPEN", "SPTAN1", "SPTBN1", "SPTLC1", "SQLE", "SQSTM1", "SRCAP", "SRM", "SRP54", "SRPK1", "SRPK2", "SRRM1", "SRSF1", "SRSF10", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSR4", "STAG2", "STAT3", "STEAP3", "STIP1", "STMN1", "STRAP", "STUB1", "STXBP3", "STXBP4", "SUCLA2", "SUCLG1", "SUCLG2", "SUGT1", "SUPT5H", "SUZ12", "SYNE2", "TACO1", "TALDO1", "TAP1", "TARDBP", "TBC1D4", "TBCA", "TBL2", "TCP1", "TDP2", "TECR", "TELO2", "TFAM", "TFRC", "THRAP3", "TIGAR", "TIMELESS", "TIMMDC1", "TIPRL", "TJP1", "TJP2", "TK1", "TKT", "TLN1", "TMED10", "TMEM126B", "TMEM43", "TMOD3", "TMPO", "TMPO", "TNKS1BP1", "TNPO1", "TOLLIP", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOPBP1", "TOR1AIP1", "TP53", "TP53BP1", "TPI1", "TPM3", "TPP1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TSC2", "TSG101", "TTC19", "TTC21B", "TTC26", "TTK", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TXNDC5", "TXNRD1", "TYMS", "U2AF2", "UBA1", "UBA3", "UBAP2L", "UBE2L3", "UBE2N", "UBR5", "UBTF", "UCHL5", "UFD1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNG", "UPF1", "UQCR10", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USMG5", "USP10", "USP5", "USP7", "USP8", "USP9X", "UTRN", "VAPA", "VAPB", "VARS1", "VBP1", "VCL", "VDAC1", "VDAC2", "VDAC3", "VIM", "VPS16", "VPS18", "VPS33A", "WAPL", "WARS", "WDHD1", "WDR1", "WDR5", "WFS1", "XAB2", "XPO1", "XPO5", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H15", "ZFR", "ZFYVE16", "ZMPSTE24", "ZNF281", "ZNF318", "ZYX"], "leading_proteins": ["ABCB1", "ABCC4", "ABCD3", "ACLY", "ADH5", "AHCY", "AHSA1", "AIFM1", "AIP", "AKAP13", "AKT2", "ALDH9A1", "ANLN", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "APLP2", "APP", "ARPC1B", "ASAH1", "ASNS", "ATP1B1", "ATP1B3", "ATP2B1", "ATP2B4", "ATP6AP1", "BLM", "BRCA1", "BSG", "C1QBP", "CALR", "CAPN2", "CBX3", "CD2AP", "CDC34", "CDK4", "CDK6", "CHKA", "CHST14", "CLTC", "CLUH", "CNN2", "CPNE1", "CSNK1A1", "CSNK2B", "CTSA", "CTTN", "CUL5", "DCTN1", "DCTN4", "DHCR24", "DHCR7", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DSG2", "DYNLL1", "ECE1", "EEF1A2", "EIF2A", "EIF2B3", "EIF2S1", "EIF2S2", "EIF3G", "EIF3H", "EIF3J", "EIF4G1", "EIF4G2", "EIF4H", "EIF5", "EIF5A", "EMD", "EML4", "EXO1", "F11R", "FASN", "FLNC", "FMR1", "GBA", "GGH", "GLA", "GLB1", "GM2A", "GNS", "GRB2", "HDAC1", "HDAC2", "HERC2", "HEXA", "HEXB", "HLA-B", "HLA-C", "HMGB1", "HSP90B1", "HTRA2", "IFT27", "ITGB1", "KLC4", "KMT2A", "LBR", "LEMD3", "LGALS3BP", "LIPA", "LLGL1", "MPST", "MTAP", "MTMR6", "MTOR", "MTR", "NAA40", "NAGLU", "NAMPT", "NAP1L1", "NAPA", "NARS", "NCSTN", "NEU1", "NPC1", "NPC2", "NSF", "OCLN", "PAK2", "PAK4", "PARP1", "PCM1", "PDHA1", "PFDN5", "PFN1", "POLR1C", "POLR3A", "PRKACA", "PRKAR1A", "PRKAR2A", "PRMT1", "PSMA6", "PSMB2", "PSMB6", "PTGES3", "PURA", "PYGL", "QKI", "RAB5B", "RALA", "REXO2", "RFC1", "RIPK1", "S100A11", "SCAMP2", "SCARB2", "SCD", "SET", "SIRT2", "SLC25A13", "SLC25A4", "SLC3A2", "SLC6A15", "SLIT2", "SMYD3", "SNW1", "SORT1", "SPTLC1", "SQSTM1", "STEAP3", "TECR", "TFAM", "TFRC", "TIMELESS", "TJP1", "TJP2", "TOR1AIP1", "TP53", "TUBB", "TUBB4B", "TUBB6", "VIM", "VPS33A", "WARS", "YWHAG", "YWHAQ", "ZFYVE16", "ZMPSTE24"]} \ No newline at end of file diff --git a/opencell_localization/advanced/idx2term.json b/opencell_localization/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/opencell_localization/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/opencell_localization/basic/idx2term.json 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b/opencell_localization/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..889d1a3a2de8364f35ed54982642e5f50dfb2d39 --- /dev/null +++ b/opencell_localization/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:44f09042f4294d98b5d4cde0c69197c4f02bc8d8b5fbce82533943540d2ef006 +size 54035 diff --git a/opencell_localization/df_merge.tsv b/opencell_localization/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..dd1ebfd47b9e5d959f2adf722e930f502d75b412 --- /dev/null +++ b/opencell_localization/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 diff --git a/opencell_localization/metrics.json b/opencell_localization/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..98243f924956316d47ce4e7168d27e281280a27e --- /dev/null +++ b/opencell_localization/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2453, + "annotations_size": 17, + "title": "Average number of proteins per term", + "value": 78.6470588235294 +} \ No newline at end of file diff --git a/opencell_localization/paths.json b/opencell_localization/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..ea6d87932d1c5b5aca0fb7f32e1f11635c404118 --- /dev/null +++ b/opencell_localization/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/opencell_localization/fragment/C334/C334_val_log2fc"} \ No newline at end of file diff --git a/opencell_localization/result.tsv b/opencell_localization/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..71133c940abf4b282c2cfc19a6e773b82fe7fb86 --- /dev/null +++ b/opencell_localization/result.tsv @@ -0,0 +1,8 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +vesicles 0.3864991935031248 1.3209694013041209 0.1865115670552919 0.9700791797684426 1.0 127 Q5VW38,O15127,P02786,Q8IY95,P31751,Q8IXU6,Q93050,Q06481,P61421,P11279,Q15904,Q7Z392,Q9H2J7,Q99747,Q13501,Q96AX1,Q96A49,Q86Y82,Q9UM00,Q15392,P20020,O15269,Q9Y678,Q9Y3E7,O43808,Q9BQC3 26 +golgi 0.4072981061727529 0.9249393713295024 0.3549974454121312 0.9994211788525026 1.0 47 Q5VW38,O15258,Q15904,Q96A49,O15127,Q7Z392,Q9Y678,Q9Y487,P40616,Q9UM00,P35606,Q8IXU6,Q9H8Y8 13 +membrane 0.337728932524438 0.4380861902871866 0.6613238047560479 0.9999999898529588 1.0 60 P04439,P61981,O15127,Q9NVZ3,Q9UQB8,P67870,P48729,P02786,Q9UNF0,P84095,Q8NC96,P31751,Q9H2G2,P20020,P35579 15 +centrosome 0.3611348522915091 0.4208625325876111 0.6738554659759983 0.9999999946547038 1.0 28 Q9NSK0,P61981,O96013,P48729,Q15691,Q7Z460,Q5SW79,P17612,P27348 9 +cell_contact 0.341896887733575 0.2817048215148708 0.7781698571293783 0.9999999999923732 1.0 20 Q9UDY2,P61981,Q9NVZ3,Q9UQB8,P48729 5 +mitochondria 0.3353777426963647 0.1803076177878411 0.8569110755549469 0.9999999999999956 1.0 11 Q8IWA4 1 +big_aggregates 0.3174569208095247 0.1793993538088123 0.8576241387421344 0.999999999999996 1.0 27 P30626,Q99615,Q9BX40,Q14997,Q14247,Q96EK5,Q92696,O95239,Q8NFH5,P62826,P52294 11 diff --git a/opencell_localization/selections.json b/opencell_localization/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..8c2d3aa1be959daab17e1c456ded558430990a34 --- /dev/null +++ b/opencell_localization/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["big_aggregates", "cell_contact", "centrosome", "chromatin", "cytoplasmic", "cytoskeleton", "er", "focal_adhesions", "golgi", "membrane", "mitochondria", "nuclear_membrane", "nuclear_punctae", "nucleolus_fc_dfc", "nucleolus_gc", "nucleoplasm", "vesicles"], "available_proteins": ["AATF", "ABCE1", "ACLY", "ACTN1", "ACTN4", "ACTR2", "AHCY", "AHSA1", "AKAP12", "AKAP13", "AKAP8L", "AKR1A1", "AKT1S1", "AKT2", "ALDH9A1", "ANAPC16", "ANKRD17", "ANXA11", "AP2B1", "APLP2", "ARF4", "ARFGAP1", "ARID1A", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARPC3", "ATG4B", "ATL2", "ATP1A1", "ATP2B1", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATP6V1H", "ATXN10", "ATXN2L", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAP31", "BLM", "BLVRA", "BMS1", "BOP1", "BRD2", "BTF3", "BUB1B", "BUD23", "BYSL", "C1orf123", "CAD", "CALD1", "CAMK2G", "CANX", "CAPRIN1", "CAPZB", "CBX1", "CCAR1", "CCDC47", "CCDC86", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC23", "CDC27", "CDC37", "CDC42", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CEP170", "CHMP3", "CHMP7", "CKAP2", "CKAP4", "CKAP5", "CKB", "CLASP1", "CLASP2", "CLINT1", "CLNS1A", "CLPTM1", "CLTC", "CNN2", "COIL", "COMMD2", "COPA", "COPB2", "COPG1", "COPG2", "COPZ1", "CORO1B", "CORO1C", "CPSF6", "CSE1L", "CSK", "CSNK1A1", "CSNK2B", "CTBP1", "CTBP2", "CTNNB1", "CTNNBL1", "CTPS1", "CTTN", "CYB5R3", "CYP51A1", "DAD1", "DBNL", "DCTN2", "DDB1", "DDOST", "DDX21", "DDX39B", "DDX47", "DDX5", "DDX56", "DDX6", "DHCR24", "DHX37", "DHX9", "DIAPH1", "DKC1", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC11", "DNAJC2", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DOCK7", "DPH2", "DRG1", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "EBNA1BP2", "EDC3", "EDC4", "EEF1G", "EFTUD2", "EIF2AK2", "EIF3B", "EIF3E", "EIF3G", "EIF3I", "EIF3K", "EIF3M", "EIF4A1", "EIF4A3", "EIF5", "EMC1", "EMC2", "EMC4", "EMC7", "EMG1", "ENO1", "ENY2", "ESD", "ESYT1", "EWSR1", "EZR", "FASN", "FAU", "FBL", "FDPS", "FKBP5", "FKBP8", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAK", "GAPDH", "GAR1", "GBF1", "GDI1", "GDI2", "GET4", "GNL2", "GNL3", "GORASP2", "GPR107", "GRB2", "GSK3A", "GSK3B", "GSPT1", "GTPBP4", "GYS1", "H1F0", "HDAC1", "HDAC2", "HEATR3", "HLA-A", "HMGA1", "HMGB2", "HMGCS1", "HNRNPA0", "HNRNPC", "HNRNPD", "HNRNPH1", "HNRNPL", "HNRNPU", "HSP90AA1", "HSP90AB1", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPB1", "HSPBP1", "HSPH1", "IDI1", "IGF2BP1", "IGF2BP3", "ILF3", "ILK", "IMP3", "INTS14", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IST1", "KDSR", "KEAP1", "KIAA0368", "KIF11", "KIF22", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC2", "KLC4", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "LAMP1", "LAMTOR2", "LARP7", "LBR", "LDHA", "LDHB", "LEMD3", "LMAN1", "LMNA", "LMNB1", "LPCAT1", "LSM14B", "LSS", "LTV1", "MAP2K1", "MAP4", "MAPRE1", "MARK2", "MBOAT7", "MDH1", "MECP2", "METAP2", "MFN1", "MFN2", "MIF", "MKI67", "MMGT1", "MPHOSPH10", "MRTO4", "MSH6", "MSN", "MTOR", "MYBBP1A", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO6", "NANS", "NAPA", "NAPG", "NCAPH", "NCKAP1", "NCL", "NCLN", "NECAP1", "NECAP2", "NEK9", "NEMF", "NHP2", "NIFK", "NOL11", "NOM1", "NONO", "NOP2", "NOP53", "NOP58", "NPM1", "NRBP1", "NSA2", "NSDHL", "NUCKS1", "NUFIP2", "NUMA1", "NUP107", "NUP153", "NUP155", "NUP214", "NUP35", "NUP98", "NUTF2", "NVL", "NXF1", "OSBP", "OSBPL11", "PABPC4", "PACSIN2", "PAK2", "PAK4", "PARP1", "PBK", "PCNA", "PDCD11", "PDCD6", "PDCD6IP", "PDCL3", "PES1", "PFDN6", "PFN1", "PGK1", "PGRMC1", "PGRMC2", "PHAX", "PHGDH", "PI4KB", "PICALM", "PIN4", "PKM", "PKN2", "PLK1", "PMPCA", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "PPM1G", "PRKACA", "PRKDC", "PRPF19", "PRPF4B", "PRPF8", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTDSS1", "PTGES3", "PTK7", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3GAP2", "RAB5A", "RAB5B", "RAB7A", "RABGAP1", "RABGGTA", "RAC1", "RACK1", "RAD21", "RAN", "RANBP1", "RANBP2", "RANBP9", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM28", "RBM34", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "REEP5", "RER1", "RHOA", "RHOG", "RIOK2", "RNASEH2A", "RNF40", "RPL10A", "RPL11", "RPL13", "RPL19", "RPL27", "RPL35", "RPL4", "RPL5", "RPLP1", "RPN1", "RPN2", "RPP30", "RPS11", "RPS14", "RPS16", "RPS18", "RPS6KA1", "RPS6KA3", "RRP1", "RSL1D1", "RTCB", "RTN4", "RUVBL1", "RUVBL2", "S100A10", "SACM1L", "SAE1", "SAR1A", "SARS", "SBDS", "SCAMP1", "SCAMP2", "SCD", "SCFD1", "SEC16A", "SEC22B", "SEC23A", "SEC24C", "SEC31A", "SEC61B", "SEPT2", "SEPT7", "SEPT9", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SGPL1", "SH3GL1", "SH3GLB1", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A17", "SLC27A4", "SLC33A1", "SLC35F2", "SLC6A15", "SLC9A3R1", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMN1*", "SNRNP40", "SNRPA", "SNRPC", "SNRPD2", "SNU13", "SNX1", "SNX12", "SNX2", "SNX3", "SNX9", "SPTLC1", "SQSTM1", "SRI", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK2", "SRPRA", "SRPRB", "SSB", "SSRP1", "STAG2", "STIP1", "STT3A", "STT3B", "STX12", "STX18", "STX7", "STX8", "SUPT16H", "SUPT5H", "SYAP1", "TARDBP", "TCF25", "TCOF1", "TFRC", "TIA1", "TJP1", "TJP2", "TMCO1", "TMED10", "TMEM192", "TMPO", "TMPO", "TNPO1", "TOLLIP", "TOMM20", "TOMM70", "TOP1", "TOP2A", "TOR1AIP1", "TPR", "TPT1", "TRAPPC11", "TRIM28", "TRIM33", "TSG101", "TSR1", "TTK", "TUBB4B", "U2AF2", "U2SURP", "UBA1", "UBE2M", "UBTF", "UFC1", "UGDH", "UPF1", "USP10", "USP36", "USP7", "UTP14A", "UTP4", "UTP6", "UTRN", "VAPA", "VAPB", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VPS16", "VPS18", "VPS29", "VPS33A", "VPS35", "VRK3", "WAPL", "WDR12", "WDR3", "WDR46", "WDR75", "XPO1", "XPO4", "XPO5", "YKT6", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZNF326", "ZYX"], "leading_proteins": ["AKT2", "APLP2", "ARL1", "ATP2B1", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "BAIAP2", "CEP170", "CHMP3", "CLASP1", "COPB2", "COPG1", "CSNK1A1", "CSNK2B", "CTTN", "DHCR24", "DNAJC7", "DPH2", "GORASP2", "GPR107", "HLA-A", "KIF4A", "KIFBP", "KLC4", "KPNA1", "LAMP1", "LSM14B", "MAPRE1", "MFN1", "MYH9", "NAPG", "NECAP1", "NECAP2", "NUP35", "PACSIN2", "PAK4", "PRKACA", "PSME4", "RABGGTA", "RAN", "RER1", "RHOG", "SCAMP2", "SLC25A17", "SLC35F2", "SLC6A15", "SLK", "SPTLC1", "SQSTM1", "SRI", "STX12", "SYAP1", "TFRC", "TJP2", "TMCO1", "TMEM192", "TRAPPC11", "VPS33A", "YWHAG", "YWHAQ"]} \ No newline at end of file diff --git a/panther_protein_class/advanced/idx2term.json b/panther_protein_class/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..93deef8a2dfdee0e8671c0fa2a77c4e58c042866 --- /dev/null +++ b/panther_protein_class/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "serine protease", "1": "membrane trafficking regulatory protein"} \ No newline at end of file diff --git a/panther_protein_class/advanced/plot_0.png b/panther_protein_class/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..6e53dd45221028af9e19dd9915fda84e7041e6b3 --- /dev/null +++ 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transporter", "3": "transporter", "4": "protein modifying enzyme", "5": "membrane traffic protein", "6": "translation initiation factor", "7": "ATP-binding cassette (ABC) transporter", "8": "chaperone", "9": "isomerase"} \ No newline at end of file diff --git a/panther_protein_class/basic/plot_0.png b/panther_protein_class/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..8e282c86de438cfc1a0b491a86bc2f3b2997e001 --- /dev/null +++ b/panther_protein_class/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:7bb38abf6cb416baafc7a62c9626b0c363823c49e8ef9a101e06613df10dbd2c +size 134463 diff --git a/panther_protein_class/basic/plot_1.png b/panther_protein_class/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..19416be270dbf23ba6ad89157e3c3892847af479 --- /dev/null +++ b/panther_protein_class/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid 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file mode 100644 index 0000000000000000000000000000000000000000..92254ac42a2c009cd1d4c709ab7f3518f760652a --- /dev/null +++ b/panther_protein_class/df_merge.tsv @@ -0,0 +1,4 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 +serine protease 5 17 2.64748184586297 0.0081093713711759 5.662621359223301 17.516990291262136 1.1445634795625386 0.1820139001244477 2.0809494011218104 1.6626107291843584 1.568325484830445 0.2384821649427795 9.216009865625694e-05 0.0013159065844779 0.0011585880107859 0.0023530303459661 +cysteine protease 2 19 2.1217259081728383 0.03386076166328 7.415048543689321 25.01941747572815 -0.1289544806835841 0.4980087250959599 4.133108887425229 4.865133695414516 1.110132682191423 0.3188225521304443 0.3491693980885609 0.0537433156025904 0.3575433799302857 0.8046349163957593 +membrane trafficking regulatory protein 5 14 1.9638768826153548 0.0495443713356194 4.949029126213592 18.78640776699029 1.0645815505395402 0.2320552342124929 2.3097144002673033 2.893415643517755 1.4460865220385617 0.2677048300346334 0.0021878047045258 0.0150469902773183 0.0017538141840637 0.013971578774249 diff --git a/panther_protein_class/metrics.json b/panther_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..17ba491dc80b23585e89d4eb50199e088222c2a4 --- /dev/null +++ b/panther_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2453, + "annotations_size": 150, + "title": "Average number of proteins per term", + "value": 11.54 +} \ No newline at end of file diff --git a/panther_protein_class/paths.json b/panther_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..7bcc5a52cacd1ab805b2873f8bd8c18d0213bb7a --- /dev/null +++ b/panther_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/panther_protein_class/fragment/C334/C334_val_log2fc"} \ No newline at end of file diff --git a/panther_protein_class/result.tsv b/panther_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..acf600ee6ecd31efac24b177a0eec38aa89ca9b4 --- /dev/null +++ b/panther_protein_class/result.tsv @@ -0,0 +1,49 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +galactosidase 0.988168094655243 2.673640075632873 0.0075032933293452 0.6768819996582205 0.0865764614924457 2 P06280 1 +serine protease 0.8257835874357418 2.64748184586297 0.0081093713711759 0.7051724518433039 0.0868861218340281 17 Q9HB40,P10619,O14773,P42785,Q9H3G5 5 +defense/immunity protein 0.960424316605468 2.559816923863299 0.0104727317322006 0.7938587167917759 0.1047273173220064 2 Q8IWZ3 1 +cysteine protease 0.6905573303668673 2.1217259081728383 0.03386076166328 0.99429890726009 0.20316456997968 19 Q92820,Q99538 2 +glycosidase 0.9594127614153104 2.0836247024065817 0.0371943182350382 0.9966053369426776 0.2145826052021438 4 Q9BTY2,P06865 2 +ion channel 0.9502280928488605 2.0605324733253436 0.0393476647319486 0.9975737451083936 0.2185981373997145 3 Q9C0H2 1 +phospholipase 0.9414505597304176 2.017232086358622 0.0436712991044196 0.9987666723371192 0.2192711593235974 4 Q8NHP8 1 +membrane trafficking regulatory protein 0.7193937976220491 1.9638768826153548 0.0495443713356194 0.9995104725580728 0.2314006548888822 14 Q96AX1,P11279,Q8WTV0,O43760,Q14108 5 +metalloprotease 0.6199976515053114 1.9394150852698735 0.0524508151081466 0.9996907822941632 0.2314006548888822 23 Q9UIQ6,P02786 2 +protease inhibitor 0.8141784041220478 1.9122230509018725 0.0558475907153463 0.9998195670474554 0.2393468173514845 8 P05067 1 +G-protein coupled receptor 0.8017135862913158 1.882597090600185 0.0597549909701529 0.999903137534448 0.2489791290423038 2 Q5VW38 1 +primary active transporter 0.6300230482001782 1.866487174674517 0.0619732367768981 0.9999320351381826 0.2502222900026563 20 O60888,P05026,Q8N4H5,P54709,O96008,Q9NS69,Q9H2J7 7 +transfer/carrier protein 0.7279071080083578 1.7967850983250848 0.0723697429712675 0.999987228677464 0.266537382832251 10 O15127,P17900 2 +transporter 0.5134011682238353 1.7937470534082125 0.0728535513074819 0.9999881899735092 0.266537382832251 49 O43772,Q99595,Q567V2,Q9UI26,Q9HD45,O60830,O95373,Q9H2D1 8 +tight junction 0.7384740922072672 1.601967157585206 0.1091628722075119 0.9999999705051392 0.3474052407147904 2 Q9UDY2 1 +major histocompatibility complex protein 0.8285714285714267 1.592957716481764 0.1111696770287329 0.99999997897048 0.3474052407147904 3 P10321,P01889 2 +transmembrane signal receptor 0.8079257286540267 1.5240081838170063 0.127506666855671 0.9999999986988792 0.3608679250632199 6 Q15375,Q8WUJ1 2 +oxidase 0.6602697186139608 1.503903696573888 0.1326061650839129 0.9999999994599305 0.3626111150139738 10 Q8NB78,P14406 2 +calmodulin-related 0.6504010934053661 1.5025411502540629 0.132957408838457 0.9999999994917648 0.3626111150139738 11 Q02818,Q14257,O43852,Q9BRK5 4 +small GTPase 0.6362433827891079 1.3596820892030552 0.1739305483822495 0.9999999999996432 0.420799713828023 9 Q3YEC7,P11233 2 +nucleic acid metabolism protein 0.7290949856642376 1.235677182275257 0.2165785824165746 1.0 0.5076060525388468 5 P49750 1 +viral or transposable element protein 0.7281632653061199 1.199042425101285 0.2305114495228739 1.0 0.5319494988989398 3 Q9H2J4,Q9NUD5 2 +protease 0.4406912632556773 1.1583317745981188 0.2467286693131685 1.0 0.5607469757117466 40 P28072,P49721,O75976 3 +SNARE protein 0.6703708515787876 1.0091816700180414 0.3128875157572586 1.0 0.6610299628674478 6 P51809,Q86Y82 2 +hydrolase 0.4592061083253937 0.9092014045244298 0.3632438229638199 1.0 0.6847552836800248 20 Q99519,O95336,Q96C86,P15586 4 +cytoskeletal protein 0.651020408163262 0.8998042487799076 0.3682244328944235 1.0 0.6847552836800248 3 Q16181,Q15019 2 +tubulin 0.6472842267532041 0.8953518470013279 0.3705990328579616 1.0 0.6847552836800248 4 Q9BUF5,P68371 2 +protein modifying enzyme 0.4504438509187363 0.8595011226744528 0.3900641008807799 1.0 0.696543037287107 20 Q92791,P50897,O15460,O60568,Q99873 5 +membrane traffic protein 0.3969952863244629 0.8330293180168314 0.4048281946956968 1.0 0.7090176116898472 45 P11717,O75436,Q9Y3E7,Q99523,Q99747,A6NIH7,Q12907 7 +translation initiation factor 0.3881092558392199 0.7594232932797335 0.4475993838625942 1.0 0.7459989731043237 44 Q04637,P78344,Q9Y262,O75822,Q15056,P46199,Q9ULC4,O75153,Q14232,Q9UJA5,P55010,O15372,O75821,P20042,P63241,Q01085,Q9NR50 17 +translational protein 0.5373317013463953 0.7135491400957221 0.4755060166918408 1.0 0.7838011264151221 2 Q12904 1 +ATP synthase 0.4280249728727638 0.6719966929008376 0.5015858016856318 1.0 0.8178029375309215 18 Q93050,Q15904,Q9Y487 3 +ATP-binding cassette (ABC) transporter 0.4912386004925087 0.6034883490717036 0.5461838639648484 1.0 0.8539849975242874 8 Q9NVZ3,Q8NC96,P08183,O15439,Q03519 5 +transferase 0.3782057642256523 0.52280055871404 0.601113050767567 1.0 0.8745013264690115 24 Q8NCH0,O43505 2 +chaperone 0.3515921193723485 0.516336934804277 0.6056191040758714 1.0 0.8745013264690115 55 O95433,Q15185,O14967,O95456,Q8IXB1,Q96KC8,Q14203,Q9Y680,Q8WUA2,Q9UHV9,Q99543,P30533,O60884,Q9NWM8,Q99471,O00170,Q8WXX5 17 +actin or actin-binding cytoskeletal protein 0.3883501889018168 0.4910607007352278 0.6233835159126302 1.0 0.888983523862218 19 O15143,Q9NYL9,Q9UHB6,Q16527 4 +voltage-gated ion channel 0.4991836734693838 0.3754487550359286 0.7073267510538759 1.0 0.9389293155582424 3 P45880,P21796 2 +nucleotide kinase 0.3807060375441552 0.3295370618385326 0.7417497855278965 1.0 0.9410450802877932 11 Q13126 1 +DNA helicase 0.3766288181923404 0.3149019984134865 0.7528360642302345 1.0 0.9410450802877932 11 P54132 1 +G-protein modulator 0.445487954267047 0.2439041101286476 0.8073050858781954 1.0 0.988926251034252 4 P52565,P31150,P50395 3 +protein-binding activity modulator 0.4433473158931544 0.2388993692483916 0.8111836146679035 1.0 0.988926251034252 4 O14530 1 +non-motor microtubule binding protein 0.340058839240832 0.2091055011491914 0.8343658803392964 1.0 0.9910518513587528 14 Q15555,P13693,Q66K74,O43663 4 +microtubule or microtubule-binding cytoskeletal protein 0.3354267608607704 0.1766384011277739 0.8597924286021152 1.0 0.9939478347180009 9 Q8WVJ2,Q08378,P63167 3 +translation factor 0.2979838818756035 0.0595340124330129 0.952526775506214 1.0 1.0 8 P51114,Q06787 2 +isomerase 0.2973415132924275 0.0586081487478912 0.9532642200798508 1.0 1.0 8 Q13907,O43708,Q9BV20,P46926,P60174,P34949,P06744 7 +secondary carrier transporter 0.2829833163958097 0.0572416485043217 0.9543527018212956 1.0 1.0 10 P55011 1 +phosphatase modulator 0.2840816326530562 0.0349996264373578 0.9720800387518442 1.0 1.0 3 Q5H9R7,P30153 2 +glycosyltransferase 0.2670669383565252 0.0052773220652705 0.9957893257463816 1.0 1.0 15 Q10472 1 diff --git a/panther_protein_class/selections.json b/panther_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..8e29ac8f81516a566b52d7c0971d8e3b781df842 --- /dev/null +++ b/panther_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthase", "ATP-binding cassette (ABC) transporter", "C2H2 zinc finger transcription factor", "DNA glycosylase", "DNA helicase", "DNA ligase", "DNA metabolism protein", "DNA methyltransferase", "DNA polymerase processivity factor", "DNA topoisomerase", "DNA-binding transcription factor", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "G-protein", "G-protein coupled receptor", "G-protein modulator", "GTPase-activating protein", "Hsp90 family chaperone", "P53-like transcription factor", "RNA helicase", "RNA metabolism protein", "RNA methyltransferase", "RNA processing factor", "RNA splicing factor", "SNARE protein", "acetyltransferase", "actin and actin related protein", "actin binding motor protein", "actin or actin-binding cytoskeletal protein", "acyltransferase", "aldolase", "amino acid kinase", "amino acid transporter", "aminoacyl-tRNA synthetase", "apolipoprotein", "aspartic protease", "basic helix-loop-helix transcription factor", "basic leucine zipper transcription factor", "cadherin", "calcium-binding protein", "calmodulin-related", "carbohydrate kinase", "centromere DNA-binding protein", "chaperone", "chaperonin", "chromatin/chromatin-binding, or -regulatory protein", "cyclase", "cysteine protease", "cytokine", "cytoskeletal protein", "damaged DNA-binding protein", "decarboxylase", "defense/immunity protein", "dehydratase", "dehydrogenase", "endodeoxyribonuclease", "endoribonuclease", "epimerase/racemase", "esterase", "exodeoxyribonuclease", "exoribonuclease", "extracellular matrix glycoprotein", "extracellular matrix protein", "galactosidase", "general transcription factor", "glucosidase", "glycosidase", "glycosyltransferase", "guanyl-nucleotide exchange factor", "heterotrimeric G-protein", "histone", "histone modifying enzyme", "homeodomain transcription factor", "hydratase", "hydrolase", "integrin", "intermediate filament binding protein", "ion channel", "isomerase", "kinase", "kinase activator", "kinase inhibitor", "kinase modulator", "ligase", "lipase", "lyase", "mRNA capping factor", "mRNA polyadenylation factor", "major histocompatibility complex protein", "membrane traffic protein", "membrane trafficking regulatory protein", "metalloprotease", "methyltransferase", "microtubule binding motor protein", "microtubule or microtubule-binding cytoskeletal protein", "mitochondrial carrier protein", "mutase", "non-motor actin binding protein", "non-motor microtubule binding protein", "non-receptor serine/threonine protein kinase", "nucleic acid metabolism protein", "nucleotide kinase", "nucleotide phosphatase", "nucleotidyltransferase", "oxidase", "oxidoreductase", "oxygenase", "peptide hormone", "peroxidase", "phosphatase", "phosphatase activator", "phosphatase modulator", "phosphodiesterase", "phospholipase", "primary active transporter", "primase", "protease", "protease inhibitor", "protein modifying enzyme", "protein phosphatase", "protein-binding activity modulator", "pyrophosphatase", "reductase", "ribosomal protein", "scaffold/adaptor protein", "secondary carrier transporter", "serine protease", "small GTPase", "structural protein", "tight junction", "transaminase", "transcription cofactor", "transfer/carrier protein", "transferase", "transketolase", "translation elongation factor", "translation factor", "translation initiation factor", "translation release factor", "translational protein", "transmembrane signal receptor", "transporter", "tubulin", "tyrosine protein kinase receptor", "ubiquitin-protein ligase", "vesicle coat protein", "viral or transposable element protein", "voltage-gated ion channel", "winged helix/forkhead transcription factor", "zinc finger transcription factor"], "available_proteins": ["AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCF1", "ABCF2", "ABHD10", "ABHD12", "ABHD6", "ACAA2", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR6", "ADAM17", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGPAT1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK6", "AKAP1", "AKAP12", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "ALYREF", "ANAPC1", "ANAPC7", "ANKHD1", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APLP2", "APOL2", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARG2", "ARHGDIA", "ARIH1", "ARIH2", "ARL1", "ARL6IP5", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD5", "ATG4B", "ATL2", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1H", "ATPIF1", "ATXN2L", "AUP1", "B4GAT1", "BAG6", "BAIAP2", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCLAF1", "BLM", "BLMH", "BLVRA", "BOP1", "BRCA1", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BZW1", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBR1", "CCAR1", "CCAR2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD3EAP", "CDC23", "CDC27", "CDC37", "CDC42", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CEBPZ", "CENPB", "CEP170", "CFL1", "CFL2", "CHAF1B", "CHERP", "CHKA", "CHMP3", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT3", "CNOT6", "CNOT7", "CNP", "COA3", "COIL", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1B", "CORO1C", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX7A2", "COX7C", "CPD", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSE1L", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DCAF13", "DCAKD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDOST", "DEK", "DENR", "DERL1", "DGCR8", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DPF2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "ECE1", "ECH1", "ECHS1", "ECI2", "ECSIT", "EDC4", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF2", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOB", "ELP1", "EMC2", "EMG1", "ENAH", "ENO1", "ENY2", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERH", "ERO1A", "ERP29", "ESD", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC3", "EXOC5", "EXOC7", "EXOSC1", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "FAHD1", "FAM98A", "FARSA", "FARSB", "FBL", "FDFT1", "FDPS", "FECH", "FEN1", "FH", "FKBP14", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATB", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDI1", "GDI2", "GFPT1", "GGH", "GINS1", "GLA", "GLB1", "GLDC", "GLE1", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOT1", "GOT2", "GPATCH4", "GPD2", "GPI", "GPR107", "GPR108", "GPRASP2", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HADHB", "HAT1", "HBS1L", "HCCS", "HDGF", "HDGFL2", "HDHD5", "HDLBP", "HEATR1", "HECTD1", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIC2", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HM13", "HMGA1", "HMGCL", "HMOX1", "HMOX2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HOXA10", "HP1BP3", "HPF1", "HPRT1", "HSD17B10", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HTRA2", "HUWE1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IGBP1", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMPDH2", "INTS11", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "ISOC1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "KARS", "KCTD12", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0368", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KLC2", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRR1", "KYAT3", "L2HGDH", "LAMP1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LBR", "LDAH", "LDHA", "LDHB", "LETM1", "LGMN", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LRPAP1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSS", "LTN1", "LYAR", "LYPLA1", "MACF1", "MAGED2", "MAGT1", "MAP1B", "MAP1S", "MAP2K1", "MAPRE1", "MAPRE2", "MARK2", "MARS", "MAT2A", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "METAP2", "METTL13", "MGEA5", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINPP1", "MMAB", "MMS19", "MOB4", "MOGS", "MORF4L1", "MPHOSPH10", "MPI", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MYBBP1A", "MYEF2", "MYG1", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAA15", "NAA25", "NAA35", "NAA50", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCBP1", "NCOA5", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA9", "NDUFAF2", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEDD4L", "NENF", "NEU1", "NHP2", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLN", "NME1", "NMT1", "NNT", "NOC4L", "NOL6", "NOL9", "NOM1", "NONO", "NOP56", "NOP58", "NPEPPS", "NPM1", "NPTN", "NRBP1", "NRDC", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUMA1", "NUP107", "NUP153", "NUP155", "NUP160", "NUP210", "NUP214", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCIAD1", "OCLN", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OTUB1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPN1", "PACSIN2", "PAFAH1B3", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PARG", "PARN", "PARP1", "PARP2", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCMT1", "PCNA", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PEBP1", "PECR", "PEPD", "PES1", "PEX14", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHC2", "PHF6", "PHGDH", "PI4KB", "PICALM", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLAA", "PLBD2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLD1", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1R10", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PPP6R3", "PPT1", "PQBP1", "PRAF2", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTCD1", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PUF60", "PURA", "PUS1", "PWP1", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB3GAP1", "RAB3GAP2", "RABGAP1", "RABGGTA", "RABL6", "RAC1", "RAD23B", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM34", "RBM4", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDX", "RECQL", "RECQL5", "REEP5", "REPS1", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIF1", "RIOK2", "RIPK1", "RNASEH2A", "RNPS1", "ROCK2", "RP2", "RPA1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP7A", "RRS1", "RSF1", "RSL1D1", "RTN4IP1", "S100A10", "S100A11", "SACM1L", "SAE1", "SAMHD1", "SAP18", "SAP30BP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF8", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCO1", "SCP2", "SCPEP1", "SCRIB", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35B2", "SLC6A15", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", 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4.245230977176689 1.1861053756197322 0.2707159726336181 0.0017602267192959 0.0005921611108071 0.0043507381112598 0.1462874219335119 +Hydrolase 8 77 2.777502211802482 0.0054778467260065 21.012135922330096 100.5121359223301 -0.2860490073063528 0.5453469972424007 9.92849915333812 10.239716522783334 1.1334611818491105 0.3594139124058108 7.567254105389467e-05 0.0021773201461115 0.0533687534221917 0.0473229142699032 +Protease 14 97 2.6800167221926614 0.0073618482408051 23.87864077669903 112.97330097087378 0.5565894930811873 0.44121745363286 8.615285022365173 8.917462185063522 1.4311973593718734 0.3778605174872721 7.719523531021813e-06 1.901656435268133e-05 0.000547035380149 0.0600890679496982 +Cysteine protease 4 33 2.2923715959557094 0.0218842096177733 11.349514563106796 41.019417475728154 -0.0736176267625159 0.5381635561769765 6.110564999958674 6.0266086077619905 1.1118643140276536 0.3333143711920384 0.1366182888425317 0.040634807083858 0.1042208499332746 0.6299619137463013 +SLC superfamily of solute carriers 9 32 2.1128381335752984 0.0346146245498426 18.888349514563107 44.33009708737864 2.1618907004737498 0.1690913715307362 9.633686860107934 5.825351940723624 1.7350998035598977 0.2760301582542676 0.5945506711510287 0.1035973042213631 0.1576947011522689 0.3974235273281969 diff --git a/pharos_dto/metrics.json b/pharos_dto/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..10e4b6a4ec52f7f147b5f3a136568493ac165d4f --- /dev/null +++ b/pharos_dto/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2453, + "annotations_size": 1637, + "title": "Average number of proteins per term", + "value": 3.1081246182040316 +} \ No newline at end of file diff --git a/pharos_dto/paths.json b/pharos_dto/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..2a73d8542b60c48651954b56b5a97ca7e541b168 --- /dev/null +++ b/pharos_dto/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_dto/fragment/C334/C334_val_log2fc"} \ No newline at end of file diff --git a/pharos_dto/result.tsv b/pharos_dto/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..435740c95c81f9be2406d01e585c749b14ba06e3 --- /dev/null +++ b/pharos_dto/result.tsv @@ -0,0 +1,68 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Receptor 0.8104452067477961 2.790113872583047 0.0052689506480543 0.999824535780306 0.0126285098255709 20 Q8WTV0,Q9UQB8,Q9ULC4,Q567V2,P11717,Q14108,A6NIH7 7 +Hydrolase 0.574732414360723 2.777502211802482 0.0054778467260065 0.9998755847408208 0.0129397331752854 77 P06865,Q99519,P11117,P07686,P10253,P50897,P16278,P15586 8 +Protease 0.5292730343518975 2.6800167221926614 0.0073618482408051 0.9999944177831908 0.0159409332939126 97 Q9HB40,Q8NHP8,Q9UIQ6,Q4KMP7,P10619,Q99538,P02786,O14773,P42785,Q92820,P42892,Q5BJF2,Q9H3G5,Q13510 14 +Cysteine protease 0.6365548132725467 2.2923715959557094 0.0218842096177733 0.9999999999999998 0.0371622937181483 33 Q92820,Q99538,Q8NHP8,Q13510 4 +SLC35 family of nucleotide sugar transporters 0.884944920440641 2.2431442006842084 0.0248875171637157 1.0 0.0410280620312212 2 Q8IXU6 1 +SLC superfamily of solute carriers 0.6129545907655704 2.1128381335752984 0.0346146245498426 1.0 0.0534567362151815 32 P55011,O43772,Q9BSK2,P08195,Q8IXU6,Q9Y6C9,Q9H2J7,O43808,Q9H2D1 9 +Ion channel 0.9502280928488605 2.0605324733253436 0.0393476647319486 1.0 0.0592023227630513 3 Q9C0H2 1 +Glycosidase 0.9429283008906896 2.032958868758724 0.0420566786733429 1.0 0.0621360857294787 3 P06865 1 +Phosphatase inhibitor 0.9146401390521736 1.9360121318075043 0.052866215128775 1.0 0.0742849735328796 5 P55209,Q01105,Q92688 3 +Transporter 0.4429736066966989 1.926133828885911 0.0540876655756101 1.0 0.075676503031858 146 Q9C0E2,Q9BSK2,O43760,P17900,O15439,Q8IXU6,Q9Y6C9,Q93050,Q9BVK6,Q8TB61,Q8TEX9,P61421,P11279,P05026,Q99523,Q9Y487,P54709,P24390,Q9H2J7,P55011,Q96AX1,O43772,Q86Y82,P51809,Q9HD45,Q03519,Q9H2D1,Q15334,Q12907,O75436,Q9BQE5,O95721,P08195,P08183,O43808 35 +Protease inhibitor 0.8031546820660727 1.868583153508942 0.0616808313593795 1.0 0.0843760422041211 8 P05067 1 +HDAC class I 0.7768257853937219 1.7727359328011207 0.0762724739474052 1.0 0.0998864318815218 2 Q13547 1 +Reductase 0.6551299828939566 1.718878216556352 0.085636549402861 1.0 0.1096925128110199 15 Q15392,Q9UBM7,Q14739 3 +Metalloprotease 0.5449421654048155 1.6982297125321428 0.0894644147133985 1.0 0.1133539062583849 33 Q9UIQ6,P02786 2 +Small GTPase 0.5773567152537554 1.5777720651542682 0.1146179835954155 1.0 0.1383699403729315 20 P11233,Q96P70,P55060,O00429,Q9UI26,P84095,O15397,O95373,P62826 9 +STE20 family 0.8232653061224477 1.5722371993506736 0.1158955513292547 1.0 0.1393982494680309 3 O96013,Q13177 2 +Epigenetic regulator 0.5479617302728277 1.5630074114632668 0.1180508515810483 1.0 0.1411608795019548 24 Q13547,Q16637,P25440,Q92769,P83916,P26358,Q8NB78,Q9H7B4,Q13185,Q7LBC6,Q99873 11 +Intracellular calcium-sensing protein 0.63170769627466 1.5032486396681108 0.1327749390150994 1.0 0.1551410243880925 13 Q02818,Q14257,O43852,Q9BRK5 4 +Calmodulin 0.63170769627466 1.5032486396681108 0.1327749390150994 1.0 0.1551410243880925 13 Q02818,Q14257,O43852,Q9BRK5 4 +Calcium-binding protein 0.6097224593722592 1.4967644596757352 0.1344545569966595 1.0 0.1564338640911364 15 Q02818,Q14257,O43852,Q9BRK5 4 +Exoribonuclease 0.7995343366204103 1.492757869773267 0.1355005790870032 1.0 0.157215671345281 6 Q9ULM6,Q9Y2L1,Q15024,Q9Y3B2 4 +Phosphatase modulator 0.7506850459436197 1.4792240510829846 0.1390804435551995 1.0 0.1605430918468614 7 P55209,Q01105,Q92688 3 +Adenylate kinase family 0.7099143206854379 1.4739333160508938 0.14049954644363 1.0 0.1617424455191437 2 P00568 1 +Translation initiation factor 0.5547438561642857 1.4514909043518778 0.1466432131650448 1.0 0.1675191486051488 20 Q04637,P78344,Q9Y262,O75822,Q15056,O75153,Q9UJA5,P55010,P20042,P63241 10 +Translation factor 0.5158218734026885 1.3750269020640735 0.1691231045571306 1.0 0.1879528324236407 25 Q04637,Q15056,O75822,Q9UJA5,O75153,P55010,P20042,P63241 8 +Chromodomain 0.7681632653061208 1.3561700717575036 0.1750450620131087 1.0 0.1930775479276326 3 Q13185,P83916 2 +G-protein 0.5101932165133192 1.340087040136445 0.1802170489507328 1.0 0.1974667397137548 25 Q8NHH9,Q9NTK5,P11233,Q96P70,P55060,O00429,Q9UI26,P84095,O15397,O95373,P62826 11 +Enzyme modulator 0.4135463945323536 1.3275300377379524 0.1843334103856813 1.0 0.2011691952009068 86 P55209,P05067,Q9H4M9,P11233,Q9Y3E7,Q99733,Q9UI26,P84095,Q01105,P43487,Q92688,Q9Y263,O95373,Q06481,O14530 15 +Ca2+-ATPases 0.7480100456000256 1.2769644190177607 0.2016148092835794 1.0 0.2171338439455391 3 P20020 1 +SLC25 family of mitochondrial transporters 0.5351458119158323 1.2475264634876817 0.2122045231105751 1.0 0.2273421494319447 18 Q9H2D1,O43772,O43808,Q9BSK2 4 +Eraser 0.7322188206411657 1.240707523684023 0.2147138139211084 1.0 0.2295864890909499 6 Q13547,Q8NB78,Q7LBC6 3 +Tight junction 0.7387755102040794 1.2406903301345458 0.2147201678669787 1.0 0.2295864890909499 3 Q9UDY2,Q16625 2 +Cell-cell junction 0.7387755102040794 1.2406903301345458 0.2147201678669787 1.0 0.2295864890909499 3 Q9UDY2,Q16625 2 +Histone deacetylase 0.738208911703877 1.2384655187028546 0.2155434998359797 1.0 0.2303163898377929 3 Q13547 1 +SRPK family 0.6556507547939642 1.229984279445311 0.2187029917975613 1.0 0.2333877428765371 2 P78362 1 +Protein methyltransferase 0.729200759001186 1.229379162243833 0.2189296792593773 1.0 0.2334774494772643 6 Q9H7B4 1 +Methyl-lysine/arginine binding protein 0.7261910864097879 1.224572422907256 0.2207363635791477 1.0 0.235250929153037 5 Q16637,Q13185,P83916 3 +CDK4 subfamily 0.6491228070175454 1.2006963303682936 0.2298690181268103 1.0 0.2446655283963514 2 Q00534 1 +Tudor domain 0.6409628722970252 1.1641392500747887 0.2443675845887134 1.0 0.2597595688128077 2 Q16637 1 +Na+/K+-ATPases 0.7183053883754241 1.160409546632847 0.2458821017557042 1.0 0.2611998705866891 3 P05026 1 +Writer 0.6693319644999733 1.1596805914393995 0.2461788750833986 1.0 0.2613455372967079 7 Q9H7B4 1 +Damaged DNA-binding protein 0.6389228886168921 1.1550108790913514 0.2480859714422814 1.0 0.2631994395664385 2 Q9NYH9 1 +Nucleotide kinase 0.7102040816326505 1.1287135137260107 0.2590187066869776 1.0 0.2745294361525522 3 P23919,P00568 2 +Mitochondrial nucleotide transporter subfamily 0.5814742103531951 1.1216624544670817 0.262005986027866 1.0 0.2774280718807352 9 Q9H2D1,O43808 2 +Serine protease 0.469553875918518 1.086095121828228 0.2774369103560405 1.0 0.2935773899501218 25 Q9HB40,P10619,Q9H3G5,O14773 4 +Phosphatase 0.4836676533516477 1.0484762866314123 0.2944192221651125 1.0 0.3108918999404995 20 P11117,Q8IWA4 2 +V-type ATPase 0.6409514194298518 1.0481724633491645 0.2945591550444195 1.0 0.3108918999404995 7 Q93050,Q9Y487 2 +Membrane trafficking regulatory protein 0.5078663502346615 1.0305378202853646 0.302757607856831 1.0 0.3189280592417197 16 O43760,Q96AX1,P11279,Q15334 4 +SNARE protein 0.6703708515787876 1.0091816700180414 0.3128875157572586 1.0 0.3293870503502459 6 P51809,Q86Y82 2 +P-type ATPases 0.6524223273263811 0.9425824922843136 0.3458944984156082 1.0 0.3627349736747923 6 P54709,P20020,P05026 3 +Tubulin 0.6472842267532041 0.8953518470013279 0.3705990328579616 1.0 0.3883934806584398 4 Q9BUF5,P68371 2 +Extracellular structure 0.561811857910971 0.7429287209361243 0.4575248360781843 1.0 0.4779630865730617 7 Q92791,Q32P28,Q96CW1 3 +Atypical group 0.5950228271486231 0.7030354235839011 0.4820336739507702 1.0 0.5029248720569859 4 Q9BVS4,P42345 2 +Cytokine 0.5234598123215082 0.6568343176199228 0.5112874554667246 1.0 0.5320899965664515 2 P43490 1 +STE group 0.5480506148708614 0.5401970984913869 0.5890611134497761 1.0 0.6099260232240882 4 O96013,Q13177 2 +Chaperone 0.3567618104928796 0.4252148941522534 0.6706800275522751 1.0 0.6900711534274508 34 Q15185,O14967,P61981,Q14203,Q9UHV9,Q99471,O00170,P27348 8 +Acyltransferase 0.4714768483758107 0.4235916864793946 0.6718636193569387 1.0 0.6908547392508221 7 Q92696 1 +Nuclease 0.3573967289909446 0.4034322478396286 0.6866302674936806 1.0 0.7047108137223543 30 Q9UQ84,Q9UHB6,Q9Y2L1,Q5JSZ5 4 +Non-motor microtubule binding protein 0.3789337986605804 0.3231493656390083 0.7465821256755776 1.0 0.7628932208058181 11 Q15555,P13693,Q66K74,O43663 4 +Reader 0.3649271813517976 0.2741341775482409 0.7839815096168246 1.0 0.7976244445262535 11 Q16637,P25440,P83916,Q13185,P45973 5 +Non-protein kinase 0.3621868869113022 0.2711473609418354 0.7862776966804506 1.0 0.7990190120232568 12 P35790,P23919 2 +Extracellular matrix glycoprotein 0.4306820739399662 0.210454588356395 0.833312891154532 1.0 0.8451878580049373 4 Q32P28 1 +Glycosyltransferase 0.3393853737176661 0.1922024197259493 0.8475836505732861 1.0 0.8570070636123962 11 Q10472 1 +Enzyme 0.2823479450403948 0.184039539232713 0.8539824368370947 1.0 0.8629439809273606 519 Q13126,Q9HB40,Q10472,P14406,Q8NHP8,Q9UIQ6,Q4KMP7,O15127,P11117,Q99538,Q9UHB6,P02786,Q8TBC4,P10253,Q13423,P42892,P50897,P55786,Q9H3G5,P16278,P15586,Q5JSZ5,P06865,Q99519,Q8NCN5,P07686,P10619,O14773,Q9H4L7,Q92820,Q10471,Q8IWA4,Q9Y2L1,Q6ZRP7,P38571,Q5BJF2,Q9BV86,Q13510,Q9NRN7,Q9ULM6,Q9UBM7,Q9H0R6,Q9UQ84,Q15392,O43847,O95881,Q7Z2Z2,Q9NRF8,O15269,Q14739,P42785,Q96C86,O95831,Q8NCH0 54 +Transaminase 0.3657902186292168 0.1043127166053615 0.9169211865769088 1.0 0.9225568423026426 5 O15269 1 +Microtubule family cytoskeletal protein 0.3027696488913705 0.099048921187855 0.921099427554283 1.0 0.9261915005567328 31 Q8WVJ2,P68371,O95239,Q15691,Q9BUF5,O43663,P07437,Q15555,Q66K74,Q9BW19,Q02241,P13693,P63167 13 +Protein kinase 0.2854005687604806 0.0252214845522923 0.9798783002114332 1.0 0.9828803783370812 45 Q13177,O96013,P67870,P48729,P42345,Q9UHY1,Q9H2G2,P31751,Q9BVS4,Q15375,Q13546 11 diff --git a/pharos_dto/selections.json b/pharos_dto/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..fd7ce0afece32cd44776edd5d7967b21adf4fd21 --- /dev/null +++ b/pharos_dto/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase", "10 kDa heat shock protein, mitochondrial", "116 kDa U5 small nuclear ribonucleoprotein component", "14-3-3 protein beta/alpha", "14-3-3 protein epsilon", "14-3-3 protein eta", "14-3-3 protein gamma", "14-3-3 protein theta", "14-3-3 protein zeta/delta", "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "2',5'-phosphodiesterase 12", "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial", "26S proteasome non-ATPase regulatory subunit 1", "26S proteasome non-ATPase regulatory subunit 12", "26S proteasome non-ATPase regulatory subunit 13", "26S proteasome non-ATPase regulatory subunit 14", "26S proteasome non-ATPase regulatory subunit 2", "26S proteasome non-ATPase regulatory subunit 3", "26S proteasome non-ATPase regulatory subunit 4", "26S proteasome non-ATPase regulatory subunit 7", "26S proteasome non-ATPase regulatory subunit 8", "26S proteasome regulatory subunit 10B", "26S proteasome regulatory subunit 4", "26S proteasome regulatory subunit 6A", "26S proteasome regulatory subunit 6B", "26S proteasome regulatory subunit 7", "26S proteasome regulatory subunit 8", "28S ribosomal protein S11, mitochondrial", "28S ribosomal protein S2, mitochondrial", "28S ribosomal protein S27, mitochondrial", "28S ribosomal protein S29, mitochondrial", "28S ribosomal protein S35, mitochondrial", "28S ribosomal protein S5, mitochondrial", "28S ribosomal protein S7, mitochondrial", "3-hydroxyacyl-CoA dehydrogenase type-2", "3-hydroxyisobutyrate dehydrogenase, mitochondrial", "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial", "3-ketoacyl-CoA thiolase, mitochondrial", "3-mercaptopyruvate sulfurtransferase", "39S ribosomal protein L1, mitochondrial", "39S ribosomal protein L11, mitochondrial", "39S ribosomal protein L12, mitochondrial", "39S ribosomal protein L14, mitochondrial", "39S ribosomal protein L19, mitochondrial", "39S ribosomal protein L2, mitochondrial", "39S ribosomal protein L21, mitochondrial", "39S ribosomal protein L24, mitochondrial", "39S ribosomal protein L38, mitochondrial", "39S ribosomal protein L39, mitochondrial", "39S ribosomal protein L44, mitochondrial", "39S ribosomal protein L47, mitochondrial", "39S ribosomal protein L48, mitochondrial", "39S ribosomal protein L9, mitochondrial", "4-trimethylaminobutyraldehyde dehydrogenase", "40S ribosomal protein S10", "40S ribosomal protein S11", "40S ribosomal protein S12", "40S ribosomal protein S13", "40S ribosomal protein S14", "40S ribosomal protein S15", "40S ribosomal protein S15a", "40S ribosomal protein S17", "40S ribosomal protein S18", "40S ribosomal protein S19", "40S ribosomal protein S2", "40S ribosomal protein S20", "40S ribosomal protein S21", "40S ribosomal protein S23", "40S ribosomal protein S24", "40S ribosomal protein S28", "40S ribosomal protein S3", "40S ribosomal protein S3a", "40S ribosomal protein S4, X isoform", "40S ribosomal protein S5", "40S ribosomal protein S6", "40S ribosomal protein S7", "40S ribosomal protein S8", "40S ribosomal protein S9", "40S ribosomal protein SA", "45 kDa calcium-binding protein", "4F2 cell-surface antigen heavy chain", "5'-nucleotidase domain-containing protein 1", "5'-nucleotidase domain-containing protein 2", "6-phosphogluconate dehydrogenase, decarboxylating", "6-phosphogluconolactonase", "60 kDa SS-A/Ro ribonucleoprotein", "60S ribosomal protein L10", "60S ribosomal protein L10a", "60S ribosomal protein L11", "60S ribosomal protein L12", "60S ribosomal protein L13", "60S ribosomal protein L13a", "60S ribosomal protein L14", "60S ribosomal protein L15", "60S ribosomal protein L18", "60S ribosomal protein L19", "60S ribosomal protein L21", "60S ribosomal protein L22", "60S ribosomal protein L23", "60S ribosomal protein L23a", "60S ribosomal protein L24", "60S ribosomal protein L27", "60S ribosomal protein L27a", "60S ribosomal protein L28", "60S ribosomal protein L29", "60S ribosomal protein L3", "60S ribosomal protein L30", "60S ribosomal protein L31", "60S ribosomal protein L32", "60S ribosomal protein L35", "60S ribosomal protein L35a", "60S ribosomal protein L36", "60S ribosomal protein L36a", "60S ribosomal protein L37", "60S ribosomal protein L38", "60S ribosomal protein L5", "60S ribosomal protein L6", "60S ribosomal protein L7", "60S ribosomal protein L7-like 1", "60S ribosomal protein L7a", "60S ribosomal protein L8", "60S ribosomal protein L9", "7,8-dihydro-8-oxoguanine triphosphatase", "7-dehydrocholesterol reductase", "7-methylguanosine phosphate-specific 5'-nucleotidase", "A-kinase anchor protein 1, mitochondrial", "ABCB subfamily", "ABCC subfamily", "ABCD subfamily of peroxisomal ABC transporters", "ADP-dependent glucokinase", "ADP-ribose pyrophosphatase, mitochondrial", "ADP-sugar pyrophosphatase", "ADP/ATP translocase 1", "ADP/ATP translocase 2", "ADP/ATP translocase 3", "AFG3-like protein 2", "AGC group", "AH receptor-interacting protein", "AK1 subfamily", "AK2 subfamily", "AKT family", "AP-1 complex subunit beta-1", "AP-1 complex subunit gamma-1", "AP-1 complex subunit mu-1", "AP-2 complex subunit alpha-1", "AP-2 complex subunit alpha-2", "AP-2 complex subunit beta", "AP-2 complex subunit mu", "AP-3 complex subunit beta-1", "AP-3 complex subunit delta-1", "AP-3 complex subunit mu-1", "AP-3 complex subunit sigma-1", "ATP synthase F(0) complex subunit B1, mitochondrial", "ATP synthase subunit alpha, mitochondrial", "ATP synthase subunit beta, mitochondrial", "ATP synthase subunit d, mitochondrial", "ATP synthase subunit e, mitochondrial", "ATP synthase subunit f, mitochondrial", "ATP synthase subunit gamma, mitochondrial", "ATP-binding cassette sub-family B member 7, mitochondrial", "ATP-binding cassette sub-family D member 3", "ATP-binding cassette sub-family F member 1", "ATP-binding cassette sub-family F member 2", "ATP-binding cassette transporter family", "ATP-citrate synthase", "ATP-dependent 6-phosphofructokinase, muscle type", "ATP-dependent 6-phosphofructokinase, platelet type", "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial", "ATP-dependent DNA helicase Q1", "ATP-dependent DNA helicase Q5", "ATP-dependent PFK group I subfamily", "ATP-dependent RNA helicase A", "ATP-dependent RNA helicase DHX29", "ATP-dependent RNA helicase DHX8", "ATP-dependent zinc metalloprotease YME1L1", "ATPase ASNA1", "ATPase family AAA domain-containing protein 3A", "ATPase family AAA domain-containing protein 3B", "ATPase inhibitor, mitochondrial", "Acetolactate synthase-like protein", "Acetyl-CoA acetyltransferase, cytosolic", "Acetyl-CoA acetyltransferase, mitochondrial", "Acetyl-coenzyme A transporter 1", "Acetyltransferase", "Acid ceramidase", "Acidic leucine-rich nuclear phosphoprotein 32 family member B", "Acidic leucine-rich nuclear phosphoprotein 32 family member E", "Aconitate hydratase, mitochondrial", "Actin and actin related protein", "Actin binding motor protein", "Actin family cytoskeletal protein", "Actin-like protein 6A", "Actin-related protein 2", "Actin-related protein 2/3 complex subunit 1A", "Actin-related protein 2/3 complex subunit 1B", "Actin-related protein 2/3 complex subunit 3", "Actin-related protein 2/3 complex subunit 4", "Actin-related protein 3", "Actin-related protein 6", "Acyl-CoA dehydrogenase family member 9, mitochondrial", "Acyl-CoA synthetase family member 3, mitochondrial", "Acyl-coenzyme A thioesterase 9, mitochondrial", "Acylamino-acid-releasing enzyme", "Acylpyruvase FAHD1, mitochondrial", "Acyltransferase", "Adenosine 3'-phospho 5'-phosphosulfate transporter 1", "Adenosine kinase", "Adenosylhomocysteinase", "Adenylate kinase 2, mitochondrial", "Adenylate kinase family", "Adenylate kinase isoenzyme 1", "Adenylate kinase isoenzyme 6", "Adenylosuccinate lyase", "Adenylosuccinate synthetase isozyme 2", "Adenylyl cyclase-associated protein 1", "Afadin", "Aflatoxin B1 aldehyde reductase member 2", "Alanine--tRNA ligase, cytoplasmic", "Alanine--tRNA ligase, mitochondrial", "Alanine/serine/cysteine transporter subfamily", "Alanyl-tRNA editing protein Aarsd1", "Alcohol dehydrogenase [NADP(+)]", "Alcohol dehydrogenase class-3", "Aldehyde dehydrogenase X, mitochondrial", "Aldehyde dehydrogenase, mitochondrial", "Aldose reductase", "Alpha-adducin", "Alpha-aminoadipic semialdehyde dehydrogenase", "Alpha-centractin", "Alpha-enolase", "Alpha-soluble NSF attachment protein", "Alpha-taxilin", "Amidophosphoribosyltransferase", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1", "Aminoacyl-tRNA synthetase", "Amyloid-beta A4 protein", "Amyloid-like protein 2", "Anaphase-promoting complex subunit 1", "Ancient ubiquitous protein 1", "Anion channel tweety (tweety) family", "Antibacterial response protein", "Antigen peptide transporter 1", "Antigen peptide transporter 2", "Apolipoprotein", "Apolipoprotein L2", "Apoptosis-inducing factor 1, mitochondrial", "Arginase-2, mitochondrial", "Asparagine synthetase [glutamine-hydrolyzing]", "Asparagine--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, mitochondrial", "Aspartic protease", "Ataxin-2-like protein", "Atlastin-2", "Atp-dependent 6-phosphofructokinase, liver type", "Atypical group", "B-cell receptor-associated protein 31", "BTB/POZ domain-containing protein KCTD12", "BUB family", "Basic leucine zipper and W2 domain-containing protein 1", "Bcl-2-associated transcription factor 1", "Beta-centractin", "Beta-galactosidase", "Beta-hexosaminidase subunit alpha", "Beta-hexosaminidase subunit beta", "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1", "Bifunctional glutamate/proline--tRNA ligase", "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial", "Bifunctional purine biosynthesis protein PURH", "Biliverdin reductase A", "Biotin--protein ligase", "Bleomycin hydrolase", "Brain-specific angiogenesis inhibitor 1-associated protein 2", "Branched-chain-amino-acid aminotransferase, mitochondrial", "Breast cancer type 1 susceptibility protein", "Bromodomain", "Bromodomain-containing protein 2", "C-1-tetrahydrofolate synthase, cytoplasmic", "C-Jun-amino-terminal kinase-interacting protein 4", "C-terminal-binding protein 1", "C-terminal-binding protein 2", "C2H2 zinc finger transcription factor", "CAAX prenyl protease 1 homolog", "CAD protein", "CAMK group", "CAMK2 family", "CAMKL family", "CCAAT/enhancer-binding protein zeta", "CCK4 family", "CCR4-NOT transcription complex subunit 1", "CCR4-NOT transcription complex subunit 3", "CCR4-NOT transcription complex subunit 6", "CCR4-NOT transcription complex subunit 7", "CDK family", "CDK1 subfamily", "CDK4 subfamily", "CDK5 subfamily", "CK1 family", "CK1 group", "CK2 family", "CLIP-associating protein 1", "CLIP-associating protein 2", "CMGC group", "COP9 signalosome complex subunit 3", "COP9 signalosome complex subunit 5", "COP9 signalosome complex subunit 6", "COP9 signalosome complex subunit 8", "CSK family", "CTP synthase 1", "CTP synthase 2", "Ca2+-ATPases", "Cadherin", "Calcium homeostasis endoplasmic reticulum protein", "Calcium uptake protein 1, mitochondrial", "Calcium uptake protein 2, mitochondrial", "Calcium-binding mitochondrial carrier protein Aralar1", "Calcium-binding mitochondrial carrier protein Aralar2", "Calcium-binding mitochondrial carrier protein SCaMC-1", "Calcium-binding protein", "Calcium/calmodulin-dependent protein kinase type ii subunit delta", "Calcium/calmodulin-dependent protein kinase type ii subunit gamma", "Calcyclin-binding protein", "Calmegin", "Calmodulin", "Calnexin", "Calpain-1 catalytic subunit", "Calpain-2 catalytic subunit", "Calponin-2", "Calponin-3", "Calreticulin", "Calumenin", "Camp-dependent protein kinase catalytic subunit alpha", "Cancer-related nucleoside-triphosphatase", "Caprin-1", "Carbohydrate kinase", "Carbohydrate sulfotransferase 14", "Carnitine O-palmitoyltransferase 2, mitochondrial", "Cartilage-associated protein", "Casein kinase i isoform alpha", "Casein kinase ii subunit beta", "Cat eye syndrome critical region protein 2", "Catechol O-methyltransferase", "Catenin alpha-1", "Catenin delta-1", "Cation-independent mannose-6-phosphate receptor", "Cell adhesion", "Cell cycle and apoptosis regulator protein 2", "Cell division control protein 42 homolog", "Cell division cycle and apoptosis regulator protein 1", "Cell-cell junction", "Cellular structure", "Cellular tumor antigen p53", "Centromere/kinetochore protein zw10 homolog", "Centrosomal protein of 170 kDa", "Chaperone", "Chaperonin", "Charged multivesicular body protein 3", "Charged multivesicular body protein 7", "Chloride channel family", "Chloride intracellular channel protein 1", "Choline kinase alpha", "Choline/ethanolamine kinase family", "Chromatin accessibility complex protein 1", "Chromatin assembly factor 1 subunit B", "Chromatin/chromatin-binding protein", "Chromobox protein homolog 1", "Chromobox protein homolog 3", "Chromobox protein homolog 5", "Chromodomain", "Chromosome-associated kinesin KIF4A", "Cilia- and flagella-associated protein 20", "Citrate synthase, mitochondrial", "ClC-3/CLCN3 subfamily", "Clathrin heavy chain 1", "Cleavage and polyadenylation specificity factor subunit 1", "Cleavage and polyadenylation specificity factor subunit 3", "Cleavage and polyadenylation specificity factor subunit 5", "Cleavage and polyadenylation specificity factor subunit 6", "Cleavage and polyadenylation specificity factor subunit 7", "Cleavage stimulation factor subunit 2", "Cleavage stimulation factor subunit 3", "Cleft lip and palate transmembrane protein 1", "Clustered mitochondria protein homolog", "Coactosin-like protein", "Coatomer subunit alpha", "Coatomer subunit beta", "Coatomer subunit beta'", "Coatomer subunit delta", "Coatomer subunit gamma-1", "Coatomer subunit gamma-2", "Coatomer subunit zeta-1", "Cohesin subunit SA-2", "Coilin", "Cold-inducible RNA-binding protein", "Condensin complex subunit 1", "Core histone macro-H2A.1", "Core histone macro-H2A.2", "Coronin-1B", "Coronin-1C", "Creatine kinase B-type", "Creatine kinase U-type, mitochondrial", "Crooked neck-like protein 1", "Cullin-1", "Cullin-2", "Cullin-4A", "Cullin-4B", "Cullin-5", "Cullin-associated NEDD8-dissociated protein 1", "Cyclase", "Cyclin-dependent kinase 1", "Cyclin-dependent kinase 12", "Cyclin-dependent kinase 2", "Cyclin-dependent kinase 4", "Cyclin-dependent kinase 6", "Cyclin-dependent-like kinase 5", "Cyclin-g-associated kinase", "Cystatin-B", "Cysteine and glycine-rich protein 2", "Cysteine and histidine-rich domain-containing protein 1", "Cysteine protease", "Cysteine protease ATG4B", "Cysteine protease inhibitor", "Cysteine--tRNA ligase, cytoplasmic", "Cytochrome b-c1 complex subunit 1, mitochondrial", "Cytochrome b-c1 complex subunit 2, mitochondrial", "Cytochrome b-c1 complex subunit 9", "Cytochrome b5 type B", "Cytochrome c oxidase subunit 2", "Cytochrome c oxidase subunit 5A, mitochondrial", "Cytochrome c oxidase subunit 5B, mitochondrial", "Cytochrome c oxidase subunit 7A2, mitochondrial", "Cytochrome c oxidase subunit 7C, mitochondrial", "Cytochrome c oxidase subunit NDUFA4", "Cytochrome c-type heme lyase", "Cytokine", "Cytoplasmic FMR1-interacting protein 1", "Cytoplasmic aconitate hydratase", "Cytoplasmic dynein 1 heavy chain 1", "Cytoplasmic dynein 1 intermediate chain 2", "Cytoplasmic dynein 1 light intermediate chain 1", "Cytoskeleton-associated protein 5", "Cytosol aminopeptidase", "Cytosolic acyl coenzyme A thioester hydrolase", "Cytosolic non-specific dipeptidase", "Cytosolic purine 5'-nucleotidase", "D-3-phosphoglycerate dehydrogenase", "DCK/DGK family", "DDB1- and CUL4-associated factor 13", "DMPK family", "DNA (cytosine-5)-methyltransferase 1", "DNA binding protein", "DNA damage-binding protein 1", "DNA helicase", "DNA ligase", "DNA ligase 3", "DNA methyltransferase", "DNA mismatch repair protein Msh2", "DNA mismatch repair protein Msh3", "DNA mismatch repair protein Msh6", "DNA polymerase processivity factor", "DNA primase small subunit", "DNA replication complex GINS protein PSF1", "DNA replication licensing factor MCM2", "DNA replication licensing factor MCM3", "DNA replication licensing factor MCM4", "DNA replication licensing factor MCM5", "DNA replication licensing factor MCM6", "DNA replication licensing factor MCM7", "DNA topoisomerase", "DNA topoisomerase 1", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "DNA-directed RNA polymerase I subunit RPA1", "DNA-directed RNA polymerase I subunit RPA2", "DNA-directed RNA polymerase II subunit RPB1", "DNA-directed RNA polymerase II subunit RPB2", "DNA-directed RNA polymerase II subunit RPB7", "DNA-directed RNA polymerase III subunit RPC1", "DNA-directed RNA polymerase III subunit RPC3", "DNA-directed RNA polymerase, mitochondrial", "DNA-directed RNA polymerases I and III subunit RPAC1", "DNA-directed RNA polymerases I, II, and III subunit RPABC1", "DNAPK subfamily", "DYRK family", "Damaged DNA-binding protein", "Deacetylase", "Deaminase", "Death-inducer obliterator 1", "Decarboxylase", "Dedicator of cytokinesis protein 7", "Dehydratase", "Dehydrogenase", "Delta(24)-sterol reductase", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial", "Delta-1-pyrroline-5-carboxylate synthase", "Density-regulated protein", "Deoxyguanosine kinase, mitochondrial", "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial", "Derlin-1", "Desmoglein-2", "Desmoplakin", "Digestive organ expansion factor homolog", "Dihydrofolate reductase", "Dihydrolipoyl dehydrogenase, mitochondrial", "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "Dihydropyrimidinase-related protein 2", "Dipeptidyl peptidase 3", "Dipeptidyl peptidase 9", "Dna-dependent protein kinase catalytic subunit", "Dolichol-phosphate mannosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B", "Double-stranded RNA-specific adenosine deaminase", "Drebrin", "Drebrin-like protein", "Dual specificity mitogen-activated protein kinase kinase 1", "Dual specificity protein kinase ttk", "Dynactin subunit 1", "Dynactin subunit 2", "Dynamin-1-like protein", "Dynamin-2", "Dynamin-like 120 kDa protein, mitochondrial", "Dynein light chain 1, cytoplasmic", "Dystonin", "E3 SUMO-protein ligase RanBP2", "E3 ubiquitin-protein ligase ARIH1", "E3 ubiquitin-protein ligase ARIH2", "E3 ubiquitin-protein ligase HUWE1", "E3 ubiquitin-protein ligase Itchy homolog", "E3 ubiquitin-protein ligase NEDD4-like", "E3 ubiquitin-protein ligase RBBP6", "E3 ubiquitin-protein ligase listerin", "EH domain-containing protein 1", "ELKS/Rab6-interacting/CAST family member 1", "ELMO domain-containing protein 2", "ER lumen protein-retaining receptor 1", "ER membrane protein complex subunit 2", "ERO1-like protein alpha", "Electron transfer flavoprotein subunit alpha, mitochondrial", "Electron transfer flavoprotein subunit beta", "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial", "Elongation factor 1-alpha 2", "Elongation factor 1-beta", "Elongation factor 1-delta", "Elongation factor 2", "Elongation factor Ts, mitochondrial", "Elongation factor Tu, mitochondrial", "Elongation factor-like GTPase 1", "Elongator complex protein 1", "Elongin-B", "Endoplasmic reticulum aminopeptidase 1", "Endoplasmic reticulum aminopeptidase 2", "Endoplasmic reticulum protein SC65", "Endoplasmic reticulum resident protein 29", "Endoplasmin", "Endoribonuclease", "Endothelin-converting enzyme 1", "Enhancer of mRNA-decapping protein 4", "Enhancer of rudimentary homolog", "Enoyl-CoA delta isomerase 2, mitochondrial", "Enoyl-CoA hydratase, mitochondrial", "Enzyme", "Enzyme modulator", "Eph family", "Ephrin type-a receptor 7", "Epigenetic regulator", "Epimerase family protein SDR39U1", "Epimerase/racemase", "Epiplakin", "Eraser", "Esterase", "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A", "Eukaryotic peptide chain release factor subunit 1", "Eukaryotic translation initiation factor 2 subunit 1", "Eukaryotic translation initiation factor 2 subunit 2", "Eukaryotic translation initiation factor 2A", "Eukaryotic translation initiation factor 3 subunit A", "Eukaryotic translation initiation factor 3 subunit B", "Eukaryotic translation initiation factor 3 subunit D", "Eukaryotic translation initiation factor 3 subunit E", "Eukaryotic translation initiation factor 3 subunit F", "Eukaryotic translation initiation factor 3 subunit H", "Eukaryotic translation initiation factor 3 subunit I", "Eukaryotic translation initiation factor 3 subunit J", "Eukaryotic translation initiation factor 3 subunit L", "Eukaryotic translation initiation factor 4 gamma 1", "Eukaryotic translation initiation factor 4 gamma 2", "Eukaryotic translation initiation factor 4 gamma 3", "Eukaryotic translation initiation factor 4B", "Eukaryotic translation initiation factor 4E", "Eukaryotic translation initiation factor 4H", "Eukaryotic translation initiation factor 5", "Eukaryotic translation initiation factor 5A-1", "Eukaryotic translation initiation factor 5B", "Eukaryotic translation initiation factor 6", "Exocyst complex component 3", "Exocyst complex component 5", "Exocyst complex component 7", "Exodeoxyribonuclease", "Exonuclease 1", "Exoribonuclease", "Exosome complex component CSL4", "Exosome complex component MTR3", "Exosome complex component RRP40", "Exosome complex component RRP42", "Exosome complex component RRP46", "Exosome complex exonuclease RRP44", "Exportin-1", "Exportin-2", "Exportin-4", "Exportin-5", "Exportin-7", "Extracellular matrix glycoprotein", "Extracellular structure", "Ezrin", "F-actin-capping protein subunit alpha-1", "F-actin-capping protein subunit alpha-2", "F-actin-capping protein subunit beta", "F-type ATPase", "F-type and V-type ATPases", "FACT complex subunit SPT16", "FRAP subfamily", "Far upstream element-binding protein 1", "Far upstream element-binding protein 2", "Far upstream element-binding protein 3", "Farnesyl pyrophosphate synthase", "Fascin", "Fatty acid synthase", "Ferrochelatase, mitochondrial", "Flap endonuclease 1", "Folate transporter 1", "Forkhead box protein C1", "Fragile X mental retardation syndrome-related protein 1", "Fragile X mental retardation syndrome-related protein 2", "Fumarate hydratase, mitochondrial", "G patch domain-containing protein 4", "G-protein", "G-protein coupled receptor", "G-protein modulator", "G-rich sequence factor 1", "GDP-L-fucose synthase", "GMP synthase [glutamine-hydrolyzing]", "GSK family", "GSK subfamily", "GTP-binding nuclear protein Ran", "GTP-binding protein 1", "GTPase Era, mitochondrial", "GTPase-activating protein and VPS9 domain-containing protein 1", "Galactokinase", "Galactosidase", "Gamma-adducin", "Gamma-glutamyl hydrolase", "Gamma-taxilin", "Gamma-tubulin complex component 2", "Gamma-tubulin complex component 3", "Ganglioside GM2 activator", "General transcription factor 3C polypeptide 3", "General transcription factor 3C polypeptide 5", "General vesicular transport factor p115", "Geranylgeranyl transferase type-2 subunit alpha", "Glucosamine-6-phosphate isomerase 1", "Glucose-6-phosphate 1-dehydrogenase", "Glucose-6-phosphate isomerase", "Glucosidase", "Glucosidase 2 subunit beta", "Glutamate dehydrogenase 1, mitochondrial", "Glutaminase kidney isoform, mitochondrial", "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1", "Glutamine--tRNA ligase", "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial", "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial", "Glutaredoxin-3", "Glutaredoxin-related protein 5, mitochondrial", "Glutathione reductase, mitochondrial", "Glutathione synthetase", "Glyceraldehyde-3-phosphate dehydrogenase", "Glycerol-3-phosphate dehydrogenase, mitochondrial", "Glycerol-3-phosphate phosphatase", "Glycine dehydrogenase (decarboxylating), mitochondrial", "Glycine--tRNA ligase", "Glycogen debranching enzyme", "Glycogen phosphorylase, brain form", "Glycogen phosphorylase, liver form", "Glycogen synthase kinase-3 alpha", "Glycogen synthase kinase-3 beta", "Glycosidase", "Glycosyltransferase", "Glycylpeptide N-tetradecanoyltransferase 1", "Glyoxylate reductase/hydroxypyruvate reductase", "Growth factor", "GrpE protein homolog 1, mitochondrial", "Guanine nucleotide-binding protein G(i) subunit alpha-2", "Guanine nucleotide-binding protein G(k) subunit alpha", "Guanine nucleotide-binding protein subunit alpha-13", "Guanyl-nucleotide exchange factor", "H(+)/Cl(-) exchange transporter 3", "H/ACA ribonucleoprotein complex subunit 1", "H/ACA ribonucleoprotein complex subunit 2", "HBS1-like protein", "HDAC class I", "HDAC class III", "HEAT repeat-containing protein 1", "Haloacid dehalogenase-like hydrolase domain-containing 5", "Heat shock protein 75 kDa, mitochondrial", "Heat shock protein HSP 90-alpha", "Heat shock protein HSP 90-beta", "Helicase", "Helix-turn-helix transcription factor", "Hepatoma-derived growth factor", "Hepatoma-derived growth factor-related protein 2", "Heterogeneous nuclear ribonucleoprotein F", "Heterogeneous nuclear ribonucleoprotein H", "Heterogeneous nuclear ribonucleoprotein H2", "Heterogeneous nuclear ribonucleoprotein H3", "Heterogeneous nuclear ribonucleoprotein K", "Heterogeneous nuclear ribonucleoprotein M", "Heterogeneous nuclear ribonucleoprotein Q", "Heterogeneous nuclear ribonucleoprotein R", "Heterotrimeric G-protein", "Hexokinase family", "Hexokinase-1", "Hexokinase-2", "High mobility group protein B1", "High mobility group protein B2", "High mobility group protein B3", "High mobility group protein HMG-I/HMG-Y", "Histidine triad nucleotide-binding protein 2, mitochondrial", "Histone", "Histone H1.0", "Histone H1.2", "Histone H1.3", "Histone H1.4", "Histone H1x", "Histone H2AX", "Histone H4", "Histone acetyltransferase type B catalytic subunit", "Histone deacetylase", "Histone deacetylase 1", "Histone deacetylase 2", "Histone deacetylase complex subunit SAP18", "Histone-arginine methyltransferase CARM1", "Histone-lysine N-methyltransferase NSD2", "Histone-lysine N-methyltransferase SMYD3", "Hormone", "Hsp90 co-chaperone Cdc37", "Hsp90 family chaperone", "Hydrolase", "Hydroxylase", "Hydroxymethylglutaryl-CoA lyase, mitochondrial", "Hypoxanthine-guanine phosphoribosyltransferase", "ILK subfamily", "Immune response", "Immunoglobulin fold transcription factor", "Immunoglobulin-binding protein 1", "Importin subunit alpha-1", "Importin subunit alpha-3", "Importin subunit alpha-4", "Importin subunit alpha-5", "Importin subunit beta-1", "Importin-11", "Importin-4", "Importin-5", "Importin-7", "Importin-8", "Importin-9", "Inactive serine/threonine-protein kinase vrk3", "Inactive tyrosine-protein kinase 7", "Induced myeloid leukemia cell differentiation protein Mcl-1", "Inorganic pyrophosphatase", "Inorganic pyrophosphatase 2, mitochondrial", "Inosine triphosphate pyrophosphatase", "Inosine-5'-monophosphate dehydrogenase 2", "Insulin-degrading enzyme", "Insulin-like growth factor 2 mRNA-binding protein 1", "Insulin-like growth factor 2 mRNA-binding protein 3", "Integrator complex subunit 11", "Integrin beta-1", "Integrin-linked kinase-associated serine/threonine phosphatase 2C", "Integrin-linked protein kinase", "Interferon-induced, double-stranded rna-activated protein kinase", "Interleukin enhancer-binding factor 3", "Intermediate filament", "Intermediate filament binding protein", "Intracellular calcium-sensing protein", "Intracellular chloride channel (clic) family", "Ion channel", "Isoaspartyl peptidase/L-asparaginase", "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial", "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial", "Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial", "Isoleucine--tRNA ligase, cytoplasmic", "Isoleucine--tRNA ligase, mitochondrial", "Isomerase", "Isopentenyl-diphosphate Delta-isomerase 1", "Isovaleryl-CoA dehydrogenase, mitochondrial", "Jumonji domain-containing", "KH domain-containing, RNA-binding, signal transduction-associated protein 1", "KRAB box transcription factor", "KRR1 small subunit processome component homolog", "Ketosamine-3-kinase", "Kinase", "Kinase activator", "Kinase inhibitor", "Kinase modulator", "Kinesin-1 heavy chain", "Kinesin-like protein KIF11", "Kinesin-like protein KIF14", "Kinesin-like protein KIF22", "Kinesin-like protein KIF23", "Kinesin-like protein KIF2A", "Kinesin-like protein KIF2C", "Kinesin-like protein KIFC1", "Kynurenine--oxoglutarate transaminase 3", "L-2-hydroxyglutarate dehydrogenase, mitochondrial", "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase", "L-lactate dehydrogenase A chain", "L-lactate dehydrogenase B chain", "LIM domain and actin-binding protein 1", "LU7TM family", "La-related protein 1", "La-related protein 4", "La-related protein 4B", "La-related protein 7", "Lamin-B receptor", "Lamina-associated polypeptide 2, isoform alpha", "Lanosterol 14-alpha demethylase", "Large proline-rich protein BAG6", "Legumain", "Lethal(2) giant larvae protein homolog 1", "Leucine-rich repeat and WD repeat-containing protein 1", "Leucine-rich repeat-containing protein 47", "Leucyl-cystinyl aminopeptidase", "Ligase", "Lipase", "Lipid kinase", "Lon protease homolog, mitochondrial", "Long-chain fatty acid transport protein 4", "Long-chain-fatty-acid--CoA ligase 1", "Long-chain-fatty-acid--CoA ligase 3", "Long-chain-fatty-acid--CoA ligase 4", "Lupus La protein", "Lyase", "Lymphokine-activated killer t-cell-originated protein kinase", "Lysine demethylase", "Lysine--tRNA ligase", "Lysine-specific demethylase", "Lysine-specific demethylase 3B", "Lysine-specific histone demethylase 1A", "Lysine-specific histone demethylase 1B", "Lysophosphatidic acid phosphatase type 6", "Lysophosphatidylcholine acyltransferase 1", "Lysophospholipid acyltransferase 7", "Lysosomal Pro-X carboxypeptidase", "Lysosomal acid lipase/cholesteryl ester hydrolase", "Lysosomal acid phosphatase", "Lysosomal alpha-glucosidase", "Lysosomal protective protein", "Lysosome membrane protein 2", "Lysosome-associated membrane glycoprotein 1", "MAGUK p55 subfamily member 2", "MAGUK p55 subfamily member 6", "MARK subfamily", "MFS-type transporter SLC18B1", "MLK family", "MMS19 nucleotide excision repair protein homolog", "MOB-like protein phocein", "Magnesium transporter protein 1", "Major histocompatibility complex antigen", "Malate dehydrogenase, cytoplasmic", "Malate dehydrogenase, mitochondrial", "Malignant T-cell-amplified sequence 1", "Mannose-6-phosphate isomerase", "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "Melanoma-associated antigen D2", "Membrane trafficking regulatory protein", "Membrane-associated progesterone receptor component 1", "Membrane-associated progesterone receptor component 2", "Metalloprotease", "Metastasis-associated protein MTA1", "Metastasis-associated protein MTA2", "Methyl-CpG-binding domain", "Methyl-CpG-binding protein 2", "Methyl-lysine/arginine binding protein", "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial", "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial", "Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial", "Methylosome subunit pICln", "Methyltransferase", "Microsomal glutathione S-transferase 2", "Microsomal glutathione S-transferase 3", "Microtubule binding motor protein", "Microtubule family cytoskeletal protein", "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5", "Microtubule-associated protein 1B", "Microtubule-associated protein 1S", "Microtubule-associated protein RP/EB family member 1", "Microtubule-associated protein RP/EB family member 2", "Minor histocompatibility antigen H13", "Miscellaneous SLC25 mitochondrial transporters", "Mitochondrial 2-oxoglutarate/malate carrier protein", "Mitochondrial Rho GTPase 1", "Mitochondrial Rho GTPase 2", "Mitochondrial amino acid transporter subfamily", "Mitochondrial carnitine/acylcarnitine carrier protein", "Mitochondrial carrier homolog 1", "Mitochondrial carrier homolog 2", "Mitochondrial di- and tri-carboxylic acid transporter subfamily", "Mitochondrial dicarboxylate carrier", "Mitochondrial folate transporter/carrier", "Mitochondrial import receptor subunit TOM20 homolog", "Mitochondrial import receptor subunit TOM40 homolog", "Mitochondrial nucleotide transporter subfamily", "Mitochondrial ornithine transporter 1", "Mitochondrial phosphate transporters", "Mitochondrial proton/calcium exchanger protein", "Mitochondrial thiamine pyrophosphate carrier", "Mitochondrial-processing peptidase subunit alpha", "Mitochondrial-processing peptidase subunit beta", "Mitofusin-1", "Mitofusin-2", "Mitotic checkpoint protein BUB3", "Mitotic checkpoint serine/threonine-protein kinase bub1 beta", "Moesin", "Monoacylglycerol lipase ABHD12", "Monoacylglycerol lipase ABHD6", "Monocarboxylate transporter 1", "Monofunctional C1-tetrahydrofolate synthase, mitochondrial", "Mortality factor 4-like protein 1", "Mpv17-like protein 2", "Multidrug resistance protein 1", "Multidrug resistance-associated protein 4", "Multifunctional protein ADE2", "Mutase", "Myb-binding protein 1A", "Myelin expression factor 2", "Myosin light polypeptide 6", "Myosin phosphatase Rho-interacting protein", "Myotubularin-related protein 6", "N-acetyl-D-glucosamine kinase", "N-acetylglucosamine-6-sulfatase", "N-acylneuraminate cytidylyltransferase", "N-alpha-acetyltransferase 15, NatA auxiliary subunit", "N-alpha-acetyltransferase 25, NatB auxiliary subunit", "N-alpha-acetyltransferase 35, NatC auxiliary subunit", "N-alpha-acetyltransferase 50", "N-terminal Xaa-Pro-Lys N-methyltransferase 1", "NAD kinase 2, mitochondrial", "NAD(P) transhydrogenase, mitochondrial", "NAD-dependent malic enzyme, mitochondrial", "NAD-dependent protein deacetylase sirtuin-2", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial", "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial", "NADP-dependent malic enzyme", "NAK family", "NEDD8-activating enzyme E1 catalytic subunit", "NEK family", "NF-kappa-B-repressing factor", "NHP2-like protein 1", "NRBP family", "NSFL1 cofactor p47", "Na+/K+-ATPases", "Nardilysin", "Neuferricin", "Neurolysin, mitochondrial", "Neuropathy target esterase", "Neuroplastin", "Neutral alpha-glucosidase AB", "Neutral amino acid transporter B(0)", "Neutral amino acid transporter subfamily", "Nicotinamide phosphoribosyltransferase", "Nipped-B-like protein", "Nischarin", "Non-POU domain-containing octamer-binding protein", "Non-motor actin binding protein", "Non-motor microtubule binding protein", "Non-protein kinase", "Nuclear RNA export factor 1", "Nuclear cap-binding protein subunit 1", "Nuclear migration protein nudC", "Nuclear pore complex protein Nup107", "Nuclear pore complex protein Nup153", "Nuclear pore complex protein Nup160", "Nuclear pore complex protein Nup214", "Nuclear pore complex protein Nup85", "Nuclear pore complex protein Nup88", "Nuclear pore complex protein Nup93", "Nuclear pore complex protein Nup98-Nup96", "Nuclear pore glycoprotein p62", "Nuclear pore membrane glycoprotein 210", "Nuclear receptor coactivator 5", "Nuclear receptor-binding protein", "Nuclease", "Nucleic acid binding", "Nucleobindin-1", "Nucleobindin-2", "Nucleolar MIF4G domain-containing protein 1", "Nucleolar complex protein 4 homolog", "Nucleolar protein 56", "Nucleolar protein 58", "Nucleolar protein 6", "Nucleolin", "Nucleophosmin", "Nucleoporin GLE1", "Nucleoporin Nup37", "Nucleoporin SEH1", "Nucleoporin p54", "Nucleoside diphosphate kinase A", "Nucleoside kinase", "Nucleosome assembly protein 1-like 1", "Nucleosome assembly protein 1-like 4", "Nucleotide kinase", "Nucleotide phosphatase", "Nucleotidyltransferase", "NudC domain-containing protein 2", "OCIA domain-containing protein 1", "Obg-like ATPase 1", "Occludin", "Ornithine aminotransferase, mitochondrial", "Other 7TM proteins", "Other group", "Other small molecule kinase", "Oxidase", "Oxidoreductase", "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial", "Oxygenase", "P-type ATPases", "P53-like transcription factor", "PAKA subfamily", "PAKB subfamily", "PC4 and SFRS1-interacting protein", "PDHK family", "PDZ and LIM domain protein 1", "PDZ and LIM domain protein 5", "PDZ and LIM domain protein 7", "PEK family", "PH-interacting protein", "PHD finger protein 6", "PI3/PI4 kinase family", "PIKK family", "PKA family", "PKN family", "PLK family", "Paired amphipathic helix protein Sin3a", "Palmitoyl-protein thioesterase 1", "Pantothenate kinase 4", "Paraspeckle component 1", "Pentatricopeptide repeat-containing protein 1, mitochondrial", "Peptidase M20 domain-containing protein 2", "Peptidyl-prolyl cis-trans isomerase FKBP4", "Peptidyl-prolyl cis-trans isomerase FKBP5", "Peptidyl-prolyl cis-trans isomerase-like 1", "Perilipin-3", "Periodic tryptophan protein 1 homolog", "Peroxidase", "Peroxiredoxin-2", "Peroxiredoxin-4", "Peroxiredoxin-6", "Peroxisomal NADH pyrophosphatase NUDT12", "Peroxisomal acyl-coenzyme A oxidase 1", "Peroxisomal membrane protein 2", "Peroxisomal membrane protein PEX14", "Peroxisomal membrane protein PMP34", "Peroxisomal trans-2-enoyl-CoA reductase", "Pescadillo homolog", "Phenylalanine--tRNA ligase beta subunit", "Phosphatase", "Phosphatase activator", "Phosphatase inhibitor", "Phosphatase modulator", "Phosphate carrier protein, mitochondrial", "Phosphatidylethanolamine-binding protein 1", "Phosphatidylinositol 4-kinase beta", "Phosphatidylinositol transfer protein alpha isoform", "Phosphatidylinositol transfer protein beta isoform", "Phosphatidylinositol-binding clathrin assembly protein", "Phosphatidylserine synthase 1", "Phosphodiesterase", "Phosphofructokinase type A (PFKA) family", "Phosphoglycerate kinase 1", "Phosphoglycerate kinase family", "Phospholipase", "Phospholipase A-2-activating protein", "Phosphoribosyl pyrophosphate synthase-associated protein 1", "Phosphoribosyl pyrophosphate synthase-associated protein 2", "Phosphorylase", "Phosphorylated adapter RNA export protein", "Pirin", "Plasma membrane calcium-transporting ATPase 1", "Plasma membrane calcium-transporting ATPase 4", "Plasminogen activator inhibitor 1 RNA-binding protein", "Plastin-1", "Plastin-3", "Plectin", "Pogo transposable element with ZNF domain", "Poly(A) RNA polymerase, mitochondrial", "Poly(A) polymerase alpha", "Poly(A)-specific ribonuclease PARN", "Poly(ADP-ribose) glycohydrolase", "Poly(rC)-binding protein 1", "Poly(rC)-binding protein 2", "Polycomb protein SUZ12", "Polyglutamine-binding protein 1", "Polyhomeotic-like protein 2", "Polymerase", "Polymerase delta-interacting protein 3", "Polypeptide N-acetylgalactosaminyltransferase 1", "Polypeptide N-acetylgalactosaminyltransferase 2", "Polyribonucleotide nucleotidyltransferase 1, mitochondrial", "Pre-mRNA-processing factor 6", "Pre-mRNA-processing-splicing factor 8", "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15", "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16", "Pre-mRNA-splicing factor RBM22", "Pre-mRNA-splicing factor SPF27", "Pre-mRNA-splicing factor SYF1", "Prefoldin subunit 2", "Prefoldin subunit 3", "Prefoldin subunit 5", "Presequence protease, mitochondrial", "Primase", "Probable 18S rRNA (guanine-N(7))-methyltransferase", "Probable ATP-dependent RNA helicase DHX37", "Probable ATP-dependent RNA helicase DHX40", "Probable RNA-binding protein 19", "Probable U3 small nucleolar RNA-associated protein 11", "Probable global transcription activator SNF2L1", "Probable leucine--tRNA ligase, mitochondrial", "Probable serine carboxypeptidase CPVL", "Procollagen galactosyltransferase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2", "Programmed cell death 6-interacting protein", "Programmed cell death protein 4", "Programmed cell death protein 5", "Prolactin regulatory element-binding protein", "Proliferating cell nuclear antigen", "Prolyl 3-hydroxylase 1", "Prolyl endopeptidase", "Propionyl-CoA carboxylase alpha chain, mitochondrial", "Propionyl-CoA carboxylase beta chain, mitochondrial", "Prostaglandin E synthase 2", "Prostaglandin E synthase 3", "Prostaglandin reductase 1", "Prostaglandin reductase 2", "Prostaglandin reductase 3", "Protease", "Protease inhibitor", "Protein AATF", "Protein CMSS1", "Protein DDI1 homolog 2", "Protein ERGIC-53", "Protein FRG1", "Protein LSM14 homolog B", "Protein NDRG3", "Protein PRRC2A", "Protein PRRC2B", "Protein PRRC2C", "Protein RRP5 homolog", "Protein Red", "Protein S100-A10", "Protein S100-A11", "Protein SCAF8", "Protein SCO1 homolog, mitochondrial", "Protein SET", "Protein Wiz", "Protein XRP2", "Protein arginine N-methyltransferase 1", "Protein arginine N-methyltransferase 3", "Protein arginine N-methyltransferase 5", "Protein arginine methyltransferase", "Protein farnesyltransferase subunit beta", "Protein gpr107", "Protein kinase", "Protein kinase C and casein kinase substrate in neurons protein 2", "Protein methyltransferase", "Protein phosphatase", "Protein phosphatase 1G", "Protein phosphatase methylesterase 1", "Protein polybromo-1", "Protein quaking", "Protein regulator of cytokinesis 1", "Protein transport protein Sec23A", "Protein transport protein Sec24A", "Protein transport protein Sec24B", "Protein transport protein Sec24C", "Protein transport protein Sec31A", "Protein transport protein Sec61 subunit alpha isoform 1", "Protein tweety homolog 3", "Protein unc-119 homolog B", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase", "Protein/nucleic acid deglycase DJ-1", "Purine nucleoside phosphorylase", "Puromycin-sensitive aminopeptidase", "Putative oxidoreductase GLYR1", "Putative phospholipase B-like 2", "Pyrophosphatase", "Pyruvate carboxylase, mitochondrial", "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial", "Pyruvate dehydrogenase protein X component, mitochondrial", "Pyruvate kinase pkm", "RIO family", "RIO2 subfamily", "RIPK family", "RNA 3'-terminal phosphate cyclase-like protein", "RNA binding protein", "RNA helicase", "RNA polymerase II subunit A C-terminal domain phosphatase SSU72", "RNA-binding motif protein, X chromosome", "RNA-binding protein 12", "RNA-binding protein 14", "RNA-binding protein 26", "RNA-binding protein 27", "RNA-binding protein 4", "RNA-binding protein EWS", "RNA-binding protein FUS", "RNA-binding protein with serine-rich domain 1", "ROCK subfamily", "RSK family", "RSK subfamily", "Rab GDP dissociation inhibitor alpha", "Rab GDP dissociation inhibitor beta", "Rab GTPase-activating protein 1", "Rab3 GTPase-activating protein non-catalytic subunit", "Rac-beta serine/threonine-protein kinase", "Radixin", "RalBP1-associated Eps domain-containing protein 1", "Ran GTPase-activating protein 1", "Ran-binding protein 3", "Ran-binding protein 9", "Ran-specific GTPase-activating protein", "Ras GTPase-activating protein-binding protein 1", "Ras GTPase-activating protein-binding protein 2", "Ras GTPase-activating-like protein IQGAP1", "Ras-related C3 botulinum toxin substrate 1", "Ras-related protein Ral-A", "Reader", "Receptor", "Receptor expression-enhancing protein 5", "Receptor-interacting serine/threonine-protein kinase 1", "Reductase", "Regulation of nuclear pre-mRNA domain-containing protein 1A", "Regulation of nuclear pre-mRNA domain-containing protein 2", "Regulator of nonsense transcripts 1", "Remodeling and spacing factor 1", "Replication factor C subunit 2", "Replication factor C subunit 3", "Replication factor C subunit 4", "Replication factor C subunit 5", "Replication protein A 70 kDa DNA-binding subunit", "Reticulocalbin-1", "Reticulocalbin-2", "Retinal dehydrogenase 2", "Retinoid-inducible serine carboxypeptidase", "Retinol dehydrogenase 11", "Rho GDP-dissociation inhibitor 1", "Rho-associated protein kinase 2", "Rho-related GTP-binding protein RhoG", "Ribonuclease H2 subunit A", "Ribonuclease P protein subunit p30", "Ribonucleoprotein", "Ribonucleoprotein PTB-binding 1", "Ribonucleoside-diphosphate reductase large subunit", "Ribonucleoside-diphosphate reductase subunit M2", "Ribosomal L1 domain-containing protein 1", "Ribosomal RNA small subunit methyltransferase NEP1", "Ribosomal RNA-processing protein 7 homolog A", "Ribosomal protein", "Ribosomal protein s6 kinase alpha-1", "Ribosomal protein s6 kinase alpha-3", "Ribosome biogenesis protein BOP1", "Ribosome biogenesis protein BRX1 homolog", "Ribosome biogenesis regulatory protein homolog", "Ribosome maturation protein SBDS", "Ribosome production factor 2 homolog", "Ribosome-recycling factor, mitochondrial", "S-adenosylhomocysteine hydrolase-like protein 1", "S-adenosylmethionine mitochondrial carrier protein", "S-adenosylmethionine synthase isoform type-2", "S-formylglutathione hydrolase", "S-methyl-5'-thioadenosine phosphorylase", "S-phase kinase-associated protein 1", "SAP30-binding protein", "SEC23-interacting protein", "SET domain", "SLC superfamily of solute carriers", "SLC1 family of amino acid transporters", "SLC12 family of cation-coupled chloride transporters", "SLC16 family of monocarboxylate transporters", "SLC18 family of vesicular amine transporters", "SLC19 family of vitamin transporters", "SLC25 family of mitochondrial transporters", "SLC27 family of fatty acid transporters", "SLC3 and SLC7 families of heteromeric amino acid transporters (HATs)", "SLC3 family", "SLC33 acetylCoA transporter", "SLC35 family of nucleotide sugar transporters", "SLC55 Mitochondrial cation/proton exchangers", "SLC56 Sideroflexins", "SLC58 MagT-like magnesium transporter family", "SLC6 neurotransmitter transporter family", "SLK subfamily", "SNARE protein", "SNW domain-containing protein 1", "SRPK family", "STE group", "STE20 family", "STE7 family", "SUMO-activating enzyme subunit 1", "SUMO-activating enzyme subunit 2", "SWI/SNF complex subunit SMARCC1", "SWI/SNF complex subunit SMARCC2", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1", "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "Scavenger receptor class B member 1", "Sec1 family domain-containing protein 1", "Secretory carrier-associated membrane protein 1", "Secretory carrier-associated membrane protein 2", "Secretory carrier-associated membrane protein 3", "Selenide, water dikinase 1", "Sentrin-specific protease 3", "Septin-2", "Septin-7", "Septin-9", "Serine hydroxymethyltransferase, cytosolic", "Serine hydroxymethyltransferase, mitochondrial", "Serine palmitoyltransferase 1", "Serine protease", "Serine protease inhibitor", "Serine--tRNA ligase, cytoplasmic", "Serine--tRNA ligase, mitochondrial", "Serine/arginine repetitive matrix protein 1", "Serine/arginine-rich splicing factor 1", "Serine/arginine-rich splicing factor 10", "Serine/arginine-rich splicing factor 11", "Serine/arginine-rich splicing factor 2", "Serine/arginine-rich splicing factor 3", "Serine/arginine-rich splicing factor 4", "Serine/arginine-rich splicing factor 5", "Serine/arginine-rich splicing factor 7", "Serine/arginine-rich splicing factor 9", "Serine/threonine-protein kinase mark2", "Serine/threonine-protein kinase mtor", "Serine/threonine-protein kinase n2", "Serine/threonine-protein kinase nek9", "Serine/threonine-protein kinase pak 2", "Serine/threonine-protein kinase pak 4", "Serine/threonine-protein kinase plk1", "Serine/threonine-protein kinase prp4 homolog", "Serine/threonine-protein kinase rio2", "Serine/threonine-protein kinase vrk1", "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "Serine/threonine-protein phosphatase 2A activator", "Serine/threonine-protein phosphatase 6 regulatory subunit 3", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit", "Serpin B6", "Serpin H1", "Sialic acid synthase", "Sialidase-1", "Sideroflexin-1", "Sigma intracellular receptor 2", "Signal peptidase complex catalytic subunit SEC11A", "Signal peptidase complex subunit 2", "Signal peptidase complex subunit 3", "Signal recognition particle 14 kDa protein", "Signal recognition particle 19 kDa protein", "Signal recognition particle 54 kDa protein", "Signal recognition particle 9 kDa protein", "Signal recognition particle receptor subunit alpha", "Signal recognition particle subunit SRP68", "Signal transducer and activator of transcription 3", "Signaling", "Single-stranded DNA-binding protein, mitochondrial", "Sister chromatid cohesion protein PDS5 homolog A", "Sister chromatid cohesion protein PDS5 homolog B", "Small GTPase", "Small nuclear ribonucleoprotein E", "Small nuclear ribonucleoprotein Sm D1", "Small nuclear ribonucleoprotein Sm D2", "Small nuclear ribonucleoprotein Sm D3", "Sodium-dependent neutral amino acid transporter B(0)AT2", "Sodium/potassium-transporting ATPase subunit alpha-1", "Sodium/potassium-transporting ATPase subunit beta-1", "Sodium/potassium-transporting ATPase subunit beta-3", "Solute carrier family 12 member 2", "Solute carrier family 25 member 33", "Solute carrier family 35 member F2", "Sortilin", "Sorting nexin-1", "Sorting nexin-2", "Spermatid perinuclear RNA-binding protein", "Spermidine synthase", "Splicing factor 1", "Splicing factor 3A subunit 1", "Splicing factor 3A subunit 2", "Splicing factor 3A subunit 3", "Splicing factor 3B subunit 1", "Splicing factor 3B subunit 3", "Splicing factor 45", "Splicing factor, proline- and glutamine-rich", "Splicing factor, suppressor of white-apricot homolog", "Squalene monooxygenase", "Squamous cell carcinoma antigen recognized by T-cells 3", "Src substrate cortactin", "Srsf protein kinase 1", "Srsf protein kinase 2", "Staphylococcal nuclease domain-containing protein 1", "Ste20-like serine/threonine-protein kinase", "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating", "Stomatin-like protein 2, mitochondrial", "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial", "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial", "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial", "Succinate-semialdehyde dehydrogenase, mitochondrial", "Sulfhydryl oxidase 2", "Superoxide dismutase [Mn], mitochondrial", "Surfeit locus protein 6", "Survival motor neuron protein", "Synaptic functional regulator FMR1", "Synaptogyrin-2", "Synaptosomal-associated protein 29", "Syntaxin-12", "Syntaxin-18", "Syntaxin-7", "Syntaxin-8", "Syntaxin-binding protein 3", "T-complex protein 1 subunit alpha", "T-complex protein 1 subunit beta", "T-complex protein 1 subunit delta", "T-complex protein 1 subunit epsilon", "T-complex protein 1 subunit eta", "T-complex protein 1 subunit gamma", "T-complex protein 1 subunit theta", "T-complex protein 1 subunit zeta", "TATA-binding protein-associated factor 2N", "TBC1 domain family member 10B", "TBC1 domain family member 13", "TBC1 domain family member 15", "TBC1 domain family member 4", "TBC1 domain family member 9B", "THO complex subunit 1", "THO complex subunit 2", "THO complex subunit 3", "THO complex subunit 4", "TK group", "TKL group", "TOPK family", "TP53-binding protein 1", "TTK family", "Target of EGR1 protein 1", "Targeting protein for Xklp2", "Thimet oligopeptidase", "Thioredoxin domain-containing protein 12", "Thioredoxin domain-containing protein 17", "Thioredoxin domain-containing protein 9", "Thioredoxin reductase 1, cytoplasmic", "Thioredoxin-dependent peroxide reductase, mitochondrial", "Threonine--tRNA ligase, cytoplasmic", "Threonine--tRNA ligase, mitochondrial", "Thymidine kinase family", "Thymidine kinase, cytosolic", "Thymidylate kinase", "Thymidylate kinase family", "Thymidylate synthase", "Thyroid hormone receptor-associated protein 3", "Tight junction", "Tight junction protein ZO-1", "Tight junction protein ZO-2", "Transaminase", "Transcription activator BRG1", "Transcription cofactor", "Transcription elongation factor A protein 1", "Transcription elongation factor SPT6", "Transcription elongation regulator 1", "Transcription factor", "Transcriptional activator protein Pur-alpha", "Transcriptional repressor p66-alpha", "Transferase", "Transferrin receptor protein 1", "Transformer-2 protein homolog alpha", "Transformer-2 protein homolog beta", "Transforming protein RhoA", "Transgelin-2", "Transketolase", "Translation elongation factor", "Translation factor", "Translation initiation factor", "Translation initiation factor IF-2, mitochondrial", "Translation release factor", "Translationally-controlled tumor protein", "Translocation protein SEC63 homolog", "Translocon-associated protein subunit alpha", "Transmembrane 9 superfamily member 3", "Transmembrane emp24 domain-containing protein 10", "Transmembrane emp24 domain-containing protein 7", "Transmembrane emp24 domain-containing protein 9", "Transport and Golgi organization protein 1 homolog", "Transporter", "Transportin-1", "Trifunctional enzyme subunit alpha, mitochondrial", "Trifunctional enzyme subunit beta, mitochondrial", "Trifunctional purine biosynthetic protein adenosine-3", "Triosephosphate isomerase", "Tripeptidyl-peptidase 1", "Tripeptidyl-peptidase 2", "Tropomodulin-3", "Tropomyosin alpha-3 chain", "Tryptophan--tRNA ligase, cytoplasmic", "Tuberin", "Tubulin", "Tubulin beta chain", "Tubulin beta-2B chain", "Tubulin beta-4B chain", "Tubulin beta-6 chain", "Tubulin-specific chaperone A", "Tubulin-specific chaperone E", "Tudor and KH domain-containing protein", "Tudor domain", "Tumor susceptibility gene 101 protein", "Twinfilin-1", "Twinfilin-2", "Tyrosine--tRNA ligase, cytoplasmic", "Tyrosine--tRNA ligase, mitochondrial", "Tyrosine-protein kinase csk", "U1 small nuclear ribonucleoprotein 70 kDa", "U1 small nuclear ribonucleoprotein A", "U2 small nuclear ribonucleoprotein A'", "U2 snRNP-associated SURP motif-containing protein", "U3 small nucleolar RNA-associated protein 14 homolog A", "U3 small nucleolar RNA-associated protein 6 homolog", "U3 small nucleolar ribonucleoprotein protein IMP3", "U3 small nucleolar ribonucleoprotein protein MPP10", "U4/U6 small nuclear ribonucleoprotein Prp3", "U4/U6 small nuclear ribonucleoprotein Prp31", "U4/U6 small nuclear ribonucleoprotein Prp4", "U4/U6.U5 tri-snRNP-associated protein 1", "U4/U6.U5 tri-snRNP-associated protein 2", "U6 snRNA-associated Sm-like protein LSm2", "U6 snRNA-associated Sm-like protein LSm6", "UDP-glucose:glycoprotein glucosyltransferase 1", "UMP-CMP kinase", "UV excision repair protein RAD23 homolog B", "Ubiquitin carboxyl-terminal hydrolase 10", "Ubiquitin carboxyl-terminal hydrolase 14", "Ubiquitin carboxyl-terminal hydrolase 36", "Ubiquitin carboxyl-terminal hydrolase 47", "Ubiquitin carboxyl-terminal hydrolase 5", "Ubiquitin carboxyl-terminal hydrolase 7", "Ubiquitin carboxyl-terminal hydrolase 8", "Ubiquitin carboxyl-terminal hydrolase isozyme L5", "Ubiquitin conjugation factor E4 A", "Ubiquitin thioesterase OTUB1", "Ubiquitin-conjugating enzyme E2 L3", "Ubiquitin-like modifier-activating enzyme 1", "Ubiquitin-like modifier-activating enzyme 6", "Ubiquitin-protein ligase", "Unclassified protein", "Unconventional myosin-Ib", "Unconventional myosin-Ic", "Unconventional myosin-VI", "V-type ATPase", "V-type proton ATPase 116 kDa subunit a isoform 1", "V-type proton ATPase 116 kDa subunit a isoform 2", "V-type proton ATPase catalytic subunit A", "V-type proton ATPase subunit B, brain isoform", "V-type proton ATPase subunit C 1", "V-type proton ATPase subunit H", "V-type proton ATPase subunit d 1", "VRK family", "Vacuolar protein sorting-associated protein 18 homolog", "Vacuolar protein sorting-associated protein 26A", "Vacuolar protein sorting-associated protein 29", "Vacuolar protein sorting-associated protein 33A", "Vacuolar protein sorting-associated protein 33B", "Vacuolar protein sorting-associated protein 35", "Vacuolar protein sorting-associated protein 4B", "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial", "Very-long-chain enoyl-CoA reductase", "Vesicle coat protein", "Vesicle-associated membrane protein 7", "Vesicle-associated membrane protein-associated protein A", "Vesicle-associated membrane protein-associated protein B/C", "Vesicle-fusing ATPase", "Vesicular integral-membrane protein VIP36", "WD repeat and HMG-box DNA-binding protein 1", "WD repeat-containing protein 1", "WD repeat-containing protein 82", "Winged helix/forkhead transcription factor", "Writer", "X-ray repair cross-complementing protein 5", "X-ray repair cross-complementing protein 6", "Xaa-Pro dipeptidase", "YEATS domain-containing protein 2", "YEATS domain-containing protein 4", "YLP motif-containing protein 1", "Zinc finger CCCH domain-containing protein 15", "Zinc finger CCCH domain-containing protein 7A", "Zinc finger CCHC domain-containing protein 8", "Zinc finger MYM-type protein 2", "Zinc finger MYM-type protein 4", "Zinc finger RNA-binding protein", "Zinc finger and BTB domain-containing protein 10", "Zinc finger protein 148", "Zinc finger protein 281", "Zinc finger protein ubi-d4", "Zinc finger transcription factor", "Zyxin", "[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial", "eIF-2-alpha kinase activator GCN1", "eukaryotic two domain clade \"e\" sub-subfamily", "m7GpppX diphosphatase", "mRNA export factor", "mRNA polyadenylation factor", "mRNA processing factor", "mRNA splicing factor", "pre-mRNA 3' end processing protein WDR33", "rRNA 2'-O-methyltransferase fibrillarin", "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6", "tRNA (cytosine(34)-C(5))-methyltransferase", "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4", "tRNA pseudouridine synthase A"], "available_proteins": ["AARS", "AARS2", "AARSD1", "AASDHPPT", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCF1", "ABCF2", "ABHD12", "ABHD6", "ACAA2", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT9", "ACOX1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR6", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADPGK", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AHCY", "AHCYL1", "AIFM1", "AIMP1", "AIP", "AK1", "AK2", "AK6", "AKAP1", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALYREF", "ANAPC1", "ANP32B", "ANP32E", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APLP2", "APOL2", "APP", "ARCN1", "ARG2", "ARHGDIA", "ARIH1", "ARIH2", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ASRGL1", "ATAD3A", "ATAD3B", "ATG4B", "ATIC", "ATL2", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1H", "ATPIF1", "ATXN2L", "AUP1", "BAG6", "BAIAP2", "BCAP31", "BCAS2", "BCAT2", "BCLAF1", "BLMH", "BLVRA", "BOP1", "BRCA1", "BRD2", "BRIX1", "BUB1B", "BUB3", "BUD23", "BZW1", "CACYBP", "CAD", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC37", "CDC42", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CEBPZ", "CECR2", "CEP170", "CFAP20", "CHAF1B", "CHERP", "CHKA", "CHMP3", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CIRBP", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLNS1A", "CLPTM1", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT3", "CNOT6", "CNOT7", "CNP", "COIL", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS3", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1B", "CORO1C", "COTL1", "COX2", "COX5A", "COX5B", "COX7A2", "COX7C", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRNKL1", "CRTAP", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL4A", "CUL4B", "CUL5", "CYB5B", "CYB5D2", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DCAF13", "DCPS", "DCTN1", "DCTN2", "DDB1", "DDI2", "DDOST", "DENR", "DERL1", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX29", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIDO1", "DIEXF", "DIS3", "DLD", "DLST", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPF2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DSG2", "DSP", "DST", "DTYMK", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "ECE1", "ECH1", "ECHS1", "ECI2", "EDC4", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3H", "EIF3I", "EIF3J", "EIF3L", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELMOD2", "ELOB", "ELP1", "EMC2", "EMG1", "ENO1", "EPHA7", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERH", "ERO1A", "ERP29", "ESD", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC3", "EXOC5", "EXOC7", "EXOSC1", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "FAHD1", "FARSB", "FASN", "FBL", "FDPS", "FECH", "FEN1", "FH", "FKBP4", "FKBP5", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FRG1", "FSCN1", "FUBP1", "FUBP3", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GCAT", "GCN1", "GDI1", "GDI2", "GFPT1", "GGH", "GINS1", "GLB1", "GLDC", "GLE1", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNPDA1", "GNS", "GPATCH4", "GPD2", "GPI", "GPR107", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GTF3C3", "GTF3C5", "GTPBP1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HADHA", "HADHB", "HAT1", "HBS1L", "HCCS", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD5", "HEATR1", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HPRT1", "HSD17B10", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HUWE1", "IARS", "IARS2", "IDE", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IGBP1", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMPDH2", "INTS11", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "ITCH", "ITGB1", "ITPA", "IVD", "KARS", "KCTD12", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KHDRBS1", "KHSRP", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRR1", "KYAT3", "L2HGDH", "LAMP1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LETM1", "LGMN", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LRRC47", "LRWD1", "LSM14B", "LSM2", "LSM6", "LTN1", "MACF1", "MAGED2", "MAGT1", "MAP1B", "MAP1S", "MAP2K1", "MAPRE1", "MAPRE2", "MARK2", "MAT2A", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MFN1", "MFN2", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MMS19", "MOB4", "MORF4L1", "MPHOSPH10", "MPI", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRPL1", "MRPL11", "MRPL12", "MRPL14", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL38", "MRPL39", "MRPL44", "MRPL47", "MRPL48", "MRPL9", "MRPS11", "MRPS2", "MRPS27", "MRPS35", "MRPS5", "MRPS7", "MRRF", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MYBBP1A", "MYEF2", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAA15", "NAA25", "NAA35", "NAA50", "NADK2", "NAGK", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NCAPD2", "NCBP1", "NCL", "NCOA5", "NDRG3", "NDUFA10", "NDUFA4", "NDUFA5", "NDUFA9", "NDUFB11", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS7", "NEDD4L", "NEK9", "NEU1", "NHP2", "NIPBL", "NISCH", "NKRF", "NLN", "NME1", "NMT1", "NNT", "NOC4L", "NOL6", "NOM1", "NONO", "NOP56", "NOP58", "NPEPPS", "NPM1", "NPTN", "NRBP1", "NRDC", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUP107", "NUP153", "NUP160", "NUP210", "NUP214", "NUP37", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCIAD1", "OCLN", "OLA1", "OPA1", "OTUB1", "P3H1", "P3H4", "PACSIN2", "PAICS", "PAK2", "PAK4", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCMT1", "PCNA", "PDCD11", "PDCD4", "PDCD5", "PDCD6IP", "PDE12", "PDHX", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PEBP1", "PECR", "PEPD", "PES1", "PEX14", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PGD", "PGK1", "PGLS", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHC2", "PHF6", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIR", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLAA", "PLBD2", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLDIP3", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PPA1", "PPA2", "PPAT", "PPIL1", "PPM1G", "PPME1", "PPP1CA", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP6R3", "PPT1", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX6", "PREB", "PREP", "PRIM1", "PRKACA", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF3", "PRPF31", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSIP1", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSPC1", "PTCD1", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PURA", "PUS1", "PWP1", "PXMP2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB3GAP2", "RABGAP1", "RABGGTA", "RAC1", "RAD23B", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAVER1", "RBBP6", "RBM12", "RBM14", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM4", "RBMX", "RCL1", "RCN1", "RCN2", "RDH11", "RDX", "RECQL", "RECQL5", "REEP5", "REPS1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIOK2", "RIPK1", "RNASEH2A", "RNPS1", "ROCK2", "RP2", "RPA1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRM1", "RRM2", "RRP7A", "RRS1", "RSF1", "RSL1D1", "S100A10", "S100A11", "SAE1", "SAP18", "SAP30BP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF8", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCO1", "SCPEP1", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B3", "SFPQ", "SFSWAP", "SFXN1", "SHMT1", "SHMT2", "SIN3A", "SIRT2", "SKP1", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35B2", "SLC35F2", "SLC3A2", "SLC6A15", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMN1*", "SMYD3", "SNAP29", "SND1", "SNRNP70", "SNRPA", "SNRPA1", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SOD2", "SORT1", "SPAG9", "SPCS2", "SPCS3", "SPTLC1", "SQLE", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSU72", "STAG2", "STAT3", "STOML2", "STRBP", "STT3A", "STT3B", "STX12", "STX18", "STX7", "STX8", "STXBP3", "SUCLA2", "SUCLG2", "SUPT16H", "SUPT6H", "SURF6", "SUZ12", "SYNCRIP", "SYNGR2", "TAF15", "TAGLN2", "TAP1", "TAP2", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCE", "TCEA1", "TCERG1", "TCP1", "TDRKH", "TECR", "TFRC", "THOC1", "THOC2", "THOC3", "THOP1", "THRAP3", "TJP1", "TJP2", "TK1", "TKT", "TM9SF3", "TMED10", "TMED7", "TMED9", "TMEM97", "TMOD3", "TMPO", "TNPO1", "TOE1", "TOMM20", "TOMM40", "TOP1", "TP53", "TP53BP1", "TPI1", "TPM3", "TPP1", "TPP2", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAP1", "TRMT6", "TROVE2", "TSC2", "TSFM", "TSG101", "TSTA3", "TTK", "TTYH3", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC9", "TXNRD1", "TYMS", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2L3", "UBE4A", "UCHL5", "UGGT1", "UNC119B", "UPF1", "UQCR10", "UQCRC1", "UQCRC2", "USO1", "USP10", "USP14", "USP36", "USP39", "USP47", "USP5", "USP7", "USP8", "UTP11", "UTP14A", "UTP6", "VAMP7", "VAPA", "VAPB", "VBP1", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4B", "VRK1", "VRK3", "WARS", "WDHD1", "WDR1", "WDR33", "WDR4", "WDR82", "WIZ", "XAB2", "XPO1", "XPO4", "XPO5", "XPO7", "XRCC5", "XRCC6", "YARS", "YARS2", "YEATS2", "YEATS4", "YLPM1", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBTB10", "ZC3H15", "ZC3H7A", "ZCCHC8", "ZFR", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZNF148", "ZNF281", "ZW10", "ZYX"], "leading_proteins": ["AASDHPPT", "ABCB1", "ABCC4", "ACP2", "AIFM1", "AIP", "AK1", "AKT2", "ANP32B", "AP2M1", "APLP2", "APOL2", "APP", "ASAH1", "ATL2", "ATP1B1", "ATP1B3", "ATP2B1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "BAIAP2", "BRD2", "CALU", "CBX1", "CBX3", "CBX5", "CDK6", "CHKA", "CHMP3", "CHST14", "CLGN", "CLUH", "CNOT6", "COX7A2", "CPVL", "CSE1L", "CSNK1A1", "CSNK2B", "CTPS2", "CTSA", "DCPS", "DCTN1", "DHCR24", "DHCR7", "DIS3", "DNM1L", "DNMT1", "DTYMK", "DYNLL1", "ECE1", "EFL1", "EHD1", "EIF2S2", "EIF3J", "EIF3L", "EIF4G1", "EIF4G2", "EIF4H", "EIF5", "EIF5A", "EPHA7", "EXO1", "EXOSC1", "EXOSC7", "GAA", "GALNT1", "GALNT2", "GGH", "GLB1", "GM2A", "GNS", "HDAC1", "HDAC2", "HEXA", "HEXB", "IGF2R", "IPO11", "IPO4", "IPO7", "IPO8", "IPO9", "KDELR1", "KDM1B", "KDM3B", "KIF23", "KIF4A", "KIFC1", "LAMP1", "LBR", "LGMN", "LIMA1", "LIPA", "LLGL1", "LMAN2", "LNPEP", "MAP1S", "MAPRE1", "MAPRE2", "MCTS1", "MFN1", "MPV17L2", "MTAP", "MTCH2", "MTOR", "NAMPT", "NAP1L1", "NAP1L4", "NEU1", "NNT", "NPEPPS", "NRBP1", "NRDC", "NTMT1", "NUCB1", "NUDCD2", "OCLN", "OLA1", "P3H1", "P3H4", "PAK2", "PAK4", "PDPR", "PFDN2", "PFDN5", "PLAA", "PLBD2", "PPT1", "PRC1", "PRCP", "PRMT1", "PRRC2B", "PTGES3", "QRSL1", "QSOX2", "RABGGTA", "RALA", "RAN", "RANBP1", "RCN2", "RHOG", "RIOK2", "RIPK1", "SCAMP2", "SCARB1", "SCARB2", "SCPEP1", "SDF4", "SET", "SLC12A2", "SLC25A17", "SLC25A20", "SLC25A32", "SLC25A33", "SLC35B2", "SLC35F2", "SLC3A2", "SLC6A15", "SLK", "SMARCAD1", "SMN1*", "SMYD3", "SNAP29", "SORT1", "SPTLC1", "SRPK2", "STX12", "SYNGR2", "TAP2", "TBC1D10B", "TFRC", "TJP2", "TM9SF3", "TMED9", "TMEM97", "TPP1", "TPT1", "TRMT6", "TTYH3", "TUBB", "TUBB4B", "TUBB6", "TXNDC12", "TXNDC9", "UBA3", "UNC119B", "UTP6", "VAMP7", "VPS26A", "VPS33A", "XPO4", "YWHAG", "YWHAQ"]} \ No newline at end of file diff --git a/pharos_protein_category/advanced/idx2term.json b/pharos_protein_category/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6e0847ffc649d08286e63465c7dfff7898d31ecd --- /dev/null +++ b/pharos_protein_category/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Tbio"} \ No newline at end of file diff --git a/pharos_protein_category/advanced/plot_0.png b/pharos_protein_category/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..2caf30f4fd4239e98b5eebad4ddd9a7b90197fb2 --- /dev/null +++ b/pharos_protein_category/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:87dbe41c6b26d4ad4efb9dfae47adfa0f8681642a54667e629de2636d68acc3c +size 215192 diff --git a/pharos_protein_category/basic/idx2term.json b/pharos_protein_category/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..1ecb89658c764c3c7d364255096dd065b0ba0c3f --- /dev/null +++ b/pharos_protein_category/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Tbio", "1": "Tchem", "2": "Tclin"} \ No newline at end of file diff --git a/pharos_protein_category/basic/plot_0.png b/pharos_protein_category/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..08e52dbdae49baa2b9f7949c535d3c2ed2f09a25 --- /dev/null +++ b/pharos_protein_category/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:b977cbd8104cb93c5da5dbac80784e12c0a558f94e868987be90fa62b80f6bf4 +size 131375 diff --git a/pharos_protein_category/basic/plot_1.png b/pharos_protein_category/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..00496a9b54381a3201b1c4cc301612e659e62ef8 --- /dev/null +++ b/pharos_protein_category/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:b75e167063b46e958b7eee8cbe875e2cf91a247501da0fdc482a8f83c1b05960 +size 125698 diff --git a/pharos_protein_category/basic/plot_2.png b/pharos_protein_category/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..5ee2a0cfe180fd22d5cd7e51ef154b38b8f2fa7f --- /dev/null +++ b/pharos_protein_category/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:6d5b059f994fe8817b58a43f5d79c7b697b7c89e9a4bf491b77aef2b2e89460d +size 134378 diff --git a/pharos_protein_category/consensus.joblib b/pharos_protein_category/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..66f00ba9c9c4084893086d3ccac50c983980ce09 --- /dev/null +++ b/pharos_protein_category/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:761baf979b58b69808874a5d733154d072426b7694b3f6ebf7dfbcd11caf42f2 +size 60515 diff --git a/pharos_protein_category/df_merge.tsv b/pharos_protein_category/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..d526b18a493ebaff7577ddd83d2b7a5bde41c39a --- /dev/null +++ b/pharos_protein_category/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 +Tbio 197 1912 4.7643236099547 1.894881914729282e-06 467.6796116504854 2434.25 -0.5416405556668178 0.3215141878443288 119.73666199244032 234.70955636597876 4.704421961664106 0.4116627836259234 0.9249403249089838 0.9029438964499884 0.2531473194462259 0.0132566443527043 diff --git a/pharos_protein_category/metrics.json b/pharos_protein_category/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..f545bf251b2e14a9ed1dbc8f95a64ddbec7590fb --- /dev/null +++ b/pharos_protein_category/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2453, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 613.0 +} \ No newline at end of file diff --git a/pharos_protein_category/paths.json b/pharos_protein_category/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..3e0493b14e28d8b4f2c86361695920551d90eb07 --- /dev/null +++ b/pharos_protein_category/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_protein_category/fragment/C334/C334_val_log2fc"} \ No newline at end of file diff --git a/pharos_protein_category/result.tsv b/pharos_protein_category/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..bbe11ad64f25fdd5afc6199b20a61295ee62e0f4 --- /dev/null +++ b/pharos_protein_category/result.tsv @@ -0,0 +1,4 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Tbio 0.1942463837132993 4.7643236099547 1.894881914729282e-06 7.579506115483518e-06 7.579527658921127e-06 1912 Q6UXD5,Q9HB40,O00584,Q08380,Q8NHP8,O75503,P11117,Q9C0H2,Q8IV08,P61916,P02786,O75153,P17900,P50897,O75976,O43505,Q14108,Q9H3G5,Q06481,P15586,O60888,Q99519,P11279,Q8IWZ3,O94813,O00461,O14773,O15118,Q567V2,Q8NB78,P54802,Q92542,Q92896,O43657,A6NIH7,Q9BV86,O43852,Q13501,O43772,O43818,Q99595,P10321,Q14126,Q9UQ84,Q9UQB8,P48723,O00148,Q14849,Q9BRK5,Q9Y624,Q9UI26,Q15392,Q86UY6,Q9HC35,Q9UNS1,P28072,Q9H2D1,Q14257,O94927,Q14739,Q3YEC7,O75179,O75436,O95456,Q9BQE5,Q07021,P11233,P08195,P67870,Q5VT66,P49427,Q96EK5,Q9NWM8,Q9UHY1,Q01105,Q8IY67,Q92688,O43464,Q12899,Q16527,Q96C86,O95831,P35613,Q8NCH0,Q8TCG1,P55209,Q10472,Q4KMP7,Q9UHX1,O15127,Q8IXB1,Q92692,Q9UHB6,Q9ULC4,Q8TBC4,O43760,Q13423,Q8IY95,Q9UMX5,Q9Y282,Q14527,Q93050,O95373,P13693,Q658P3,Q8TEX9,Q9NYL9,Q15185,P60900,P83916,Q16630,Q7Z4V5,Q8IXK0,Q8NCN5,Q96G23,P26368,Q99733,Q9Y487,Q9H4L7,O60884,Q96JB3,Q10471,Q8IWA4,Q9Y2L1,Q6ZRP7,Q16763,Q66K74,P23919,Q99747,O00170,O14979,Q96AX1,Q9NRN7,Q9ULM6,Q86Y82,Q9H0R6,Q12802,Q9UHG3,Q7Z739,P61163,P80303,P51809,P01889,O43663,O15143,O14925,O43847,O95881,P43487,Q03519,Q7Z2Z2,Q96PU8,Q9ULM3,Q5SRE5,Q9NRF8,Q15334,Q12907,Q9BZZ5,Q9UG56,Q9BZH6,Q9BRT9,P29083,O95721,Q8N1G2,Q9Y680,Q9Y3E7,Q9NXR7,Q99543,Q92804,Q93034,P84095,P17858,O60701,O43808,Q7Z6Z7,Q9BQC3,Q9P287,Q15165,P82979,O15460,O14530,P35637,Q14738,Q9C0E2,Q9H3P7,Q6FI81,Q9H4M9,Q9BSK2,Q92791,Q01844,P53999,O95336,O43396,P58546,Q9BW92,Q9BW91,Q9NRX1 197 +Tchem 0.4049284905115764 1.4423380281086955 0.149207037184806 0.4760431093440524 0.298414074369612 261 P05067,Q13126,Q9UIQ6,Q99538,Q9Y2K7,Q9BTY2,P42892,P54132,P55786,P11717,P16278,P06865,Q8WTV0,Q15904,P07686,P10619,Q99523,Q92820,Q15375,P51790,Q9H2J7,P38571,Q5BJF2,Q13510,P35790,Q02818,Q9UBM7,P04062,P08236,O15269,Q15056,P42785,Q9H7B4,Q99873 34 +Tclin 0.3586120302488089 0.7230238365924835 0.4696652398109857 0.9208956486765038 0.626220319747981 70 Q13547,P55011,Q9P032,P49721,P05026,Q9Y2I1,P06280,P42345,Q9BUF5,P10253,P54709,O43676,P05556 13 diff --git a/pharos_protein_category/selections.json b/pharos_protein_category/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..52351a629446c76286f5974b2ecfd2387b7af83e --- /dev/null +++ b/pharos_protein_category/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Tbio", "Tchem", "Tclin", "Tdark"], "available_proteins": ["AAAS", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABHD10", "ABHD12", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR6", "ADAM17", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC5", "ANAPC7", "ANK3", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOL2", "APOO", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG4B", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "B4GAT1", "BABAM1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCL2L12", "BCLAF1", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPTF", "BRCA1", "BRD2", "BRI3BP", "BRIX1", "BRMS1L", "BROX", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BYSL", "BZW1", "C12orf43", "C12orf73", "C15orf39", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C5orf15", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC47", "CCDC6", "CCDC86", "CCDC97", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD3EAP", "CDC123", "CDC23", "CDC27", "CDC34", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKAL1", "CEBPZ", "CECR2", "CELF1", "CENPB", "CENPI", "CEP170", "CERS2", "CFAP20", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD4", "CHERP", "CHID1", "CHKA", "CHMP3", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT10", "CNOT3", "CNOT6", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG7", "COIL", "COLGALT1", "COMMD2", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "CORO1B", "CORO1C", "COTL1", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DGCR8", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPF2", "DPH2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "ENSA", "ENY2", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERH", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120B", "FAM162A", "FAM208A", "FAM49B", "FAM8A1", "FAM98A", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FDFT1", "FDPS", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FOXK1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GIGYF2", "GINS1", "GINS4", "GLA", "GLB1", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLGB1", "GOLIM4", "GORASP2", "GOT1", "GOT2", "GPAA1", "GPATCH4", "GPD2", "GPI", "GPR107", "GPR108", "GPRASP2", "GPS1", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAUS5", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIC2", "HIF1AN", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOXA10", "HP1BP3", "HPF1", "HPRT1", "HPS6", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMPDH2", "INA", "INCENP", "INF2", "INTS11", "INTS14", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRGQ", "IRS4", "ISOC1", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JPT2", "JUP", "KARS", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIAA2013", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC2", "KLC4", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMP1", "LAMTOR1", "LAMTOR2", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDAH", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3BP", "LGMN", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L3", "LYAR", "LYPLA1", "MACF1", "MAGED2", "MAGT1", "MAK16", "MAP1B", "MAP1S", "MAP2K1", "MAP4", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARCKSL1", "MARK2", "MARS", "MAT2A", "MATR3", "MAU2", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED16", "METAP2", "METTL13", "MFN1", "MFN2", "MGEA5", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MINPP1", "MKI67", "MLEC", "MMAB", "MMGT1", "MMS19", "MOB4", "MOGS", "MORF4L1", "MOV10", "MPHOSPH10", "MPI", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MYBBP1A", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFAF7", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFCD", "NEMF", "NENF", "NES", "NEU1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NPTN", "NRBP1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT12", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "OAT", "OCIAD1", "OCLN", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL11", "OSBPL6", "OSBPL9", "OTUB1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIGS", "PIGT", "PIN4", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLAA", "PLBD2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1R10", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PPP6R3", "PPT1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTRH2", "PTRHD1", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RABGGTA", "RABL6", "RAC1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAD51AP1", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM34", "RBM39", "RBM4", "RBM45", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "RECQL5", "REEP5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIF1", "RINT1", "RIOK2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF114", "RNF20", "RNF40", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA3", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF8", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC3A2", "SLC6A15", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX2", "SNX3", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPCS2", "SPCS3", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SQLE", "SQSTM1", "SRCAP", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "SSU72", "STAG2", "STARD3", "STAT3", "STAU1", "STAU2", "STEAP3", "STIP1", "STMN1", "STOML2", "STRAP", "STRBP", "STRN4", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TACO1", "TAF15", "TAGLN2", "TALDO1", "TAMM41", "TAP1", "TAP2", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF25", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TEX10", "TFAM", "TFG", "TFRC", "THG1L", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMMDC1", "TIPRL", "TJP1", "TJP2", "TK1", "TKT", "TLN1", "TM9SF3", "TMCO1", "TMED10", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM126B", "TMEM192", "TMEM201", "TMEM205", "TMEM214", "TMEM230", "TMEM33", "TMEM43", "TMEM65", "TMEM97", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX4", "TNKS1BP1", "TNPO1", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOX4", "TP53", "TP53BP1", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC5", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRMT6", "TRMU", "TRNT1", "TROVE2", "TSC2", "TSFM", "TSG101", "TSN", "TSPAN6", "TSR1", "TSTA3", "TTC1", "TTC19", "TTC21B", "TTC26", "TTC37", "TTC38", "TTC4", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBL5", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UCHL5", "UFC1", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF3B", "UQCR10", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USMG5", "USO1", "USP10", "USP14", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VPS13A", "VPS16", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WBP11", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR43", "WDR45B", "WDR46", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIZ", "WRAP53", "XAB2", "XPNPEP1", "XPO1", "XPO4", "XPO5", "XPO7", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YEATS2", "YEATS4", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBTB10", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZDHHC20", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZNF148", "ZNF281", "ZNF318", "ZNF326", "ZNF638", "ZNF687", "ZRANB2", "ZW10", "ZYX"], "leading_proteins": ["AASDHPPT", "ACBD3", "ACP2", "ACTR1A", "AIFM1", "AIP", "AKAP13", "ANKHD1", "ANKRD17", "ANP32B", "API5", "APLP2", "APOL2", "APP", "ARPC1B", "ASAH1", "ATP1B1", "ATP1B3", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "B4GAT1", "BABAM2", "BAIAP2", "BCCIP", "BLM", "BSG", "C1QBP", "CALU", "CBX1", "CDC34", "CERS2", "CHKA", "CHMP3", "CHST14", "CIAPIN1", "CIP2A", "CLCN3", "CLN5", "CLUH", "CMTR1", "CNOT6", "CPD", "CPSF6", "CPVL", "CSNK2B", "CSRP2", "CTPS2", "CTSA", "CUL5", "CUTA", "DCPS", "DDX39A", "DHCR24", "DHCR7", "DIS3", "DNAJA2", "DNAJC10", "DNAJC2", "DPH2", "DSG2", "DTYMK", "ECE1", "EFL1", "EHD1", "EIF4H", "EML4", "EPHA7", "ERGIC3", "EWSR1", "EXO1", "F11R", "FKBP14", "FKBP7", "FUCA2", "FUS", "GAA", "GALNT1", "GALNT2", "GBA", "GGH", 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file mode 100644 index 0000000000000000000000000000000000000000..3084167bab3da0a271f2f77a2af01dad26a63bf5 --- /dev/null +++ b/protein_atlas_biological_process/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:44f976db2e85306a3c1cc85957258aad76b0e9ca86e18e308a7147132231e1bd +size 71913 diff --git a/protein_atlas_biological_process/df_merge.tsv b/protein_atlas_biological_process/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..e86e2ad7240eb6c78d266c943e0f9919654559c4 --- /dev/null +++ b/protein_atlas_biological_process/df_merge.tsv @@ -0,0 +1,9 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 +Lipid degradation 2 10 2.386220101416421 0.0170225597401247 3.3980582524271843 13.851941747572816 -0.343369950147961 0.3045532232627618 1.531797635657744 2.5957248490069755 1.3205422581136184 0.2334417912419557 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0.0213173747373747 7.703883495145631 26.439320388349515 1.128083592407629 0.3052190273048834 3.279782799169419 3.1412859163137186 1.216134343451914 0.3162944576553002 0.0296703391700837 1.5043426137713009e-05 0.0003553897568888 0.0169271631671333 +Transport 77 374 2.145927989290232 0.0318787243441029 127.39320388349516 491.7621359223301 1.4832290368286314 0.5289485259644714 40.31460927260851 50.077723312236 2.248556521823017 0.4543981544818752 0.1247122395209128 0.022111363679642 0.0019152775148941 4.984264471153878e-08 +Ion transport 13 40 2.1089560607060327 0.0349483745047778 19.82766990291262 54.68446601941748 1.177785596906995 0.303722365376275 8.99659651977233 7.41832233515522 1.8666057057567336 0.3607289685223158 0.2424615860147684 0.1196626533568286 0.0983459396182325 0.0488446126882417 +Sphingolipid metabolism 3 7 1.9606235394639264 0.0499229543477923 5.075242718446602 9.720873786407768 1.0723891387155546 0.1672146303539832 2.245095774833478 1.0461446620678432 1.744521381224598 0.248179764200939 0.0892490045576324 3.0155128003151412e-05 0.0010078083449561 0.012134686324044 diff --git a/protein_atlas_biological_process/metrics.json b/protein_atlas_biological_process/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..8f38504849f0309a41aa8d79661524d016588fd1 --- /dev/null +++ b/protein_atlas_biological_process/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2453, + "annotations_size": 159, + "title": "Average number of proteins per term", + "value": 25.59119496855346 +} \ No newline at end of file diff --git a/protein_atlas_biological_process/paths.json b/protein_atlas_biological_process/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..558326a2d7f9deba5b6b2539ebe169bffef5c7b6 --- /dev/null +++ b/protein_atlas_biological_process/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_biological_process/fragment/C334/C334_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_biological_process/result.tsv b/protein_atlas_biological_process/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..1e47e88812d6adca0f2d48774d66ca36ec468529 --- /dev/null +++ b/protein_atlas_biological_process/result.tsv @@ -0,0 +1,48 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Lipid degradation 0.870464171654516 2.386220101416421 0.0170225597401247 0.9347734268128454 0.0917823328387358 10 Q99519,Q8NHP8 2 +Cholesterol metabolism 0.7818929018647325 2.3853681030363205 0.0170620394420966 0.9351886434395328 0.0917823328387358 16 Q9UBM7,P61916,O15118,Q15392,P04062,Q14739 6 +Sterol metabolism 0.7631658240798275 2.3560201425679743 0.018471916043016 0.9484137299977544 0.0917823328387358 17 Q9UBM7,P61916,O15118,Q15392,P04062,Q14739 6 +Cell adhesion 0.6982624390468588 2.3217945400736077 0.020244001395719 0.9612964276407492 0.0975392794521007 22 Q14126,P05067,Q92692,Q08380 4 +Steroid metabolism 0.7392814245771633 2.302315705982609 0.0213173747373747 0.9674868800865696 0.0996900759777229 18 Q9UBM7,P61916,O15118,Q15392,P04062,Q14739 6 +Transport 0.3607134190960662 2.145927989290232 0.0318787243441029 0.9942079468688432 0.1333872939661151 374 Q9C0H2,P61916,Q8IXU6,O60830,P11717,Q15904,Q99523,O00461,O15118,P51790,Q9H2J7,A6NIH7,O43772,Q99595,Q14849,Q9UI26,Q8N4H5,Q9H2D1,O75436,Q9BQE5,P08195,Q8N4V1,O15127,Q8NC96,Q9Y282,Q93050,O95373,Q658P3,Q8TEX9,Q9Y487,Q99747,P55011,Q96AX1,Q9HD20,Q86Y82,P51809,O14925,Q03519,Q96PU8,Q5SRE5,Q12907,O95721,Q9Y3E7,P08183,O43808,P82979,Q9C0E2,Q9H4M9,Q9BSK2,O43396,P31751,O15439,Q9Y6C9,Q9BVK6,Q8TB61,P61421,P05026,O14828,Q06787,Q7Z392,Q9UID3,Q9NVZ3,Q9NPA8,Q969Q5,P54709,P24390,O96008,O14949,Q9NS69,Q9Y4C2,P49069,Q14203,Q9UM00,Q6NUQ1,Q8NFH4,P20020,O43676 77 +Ion transport 0.567837375442319 2.1089560607060327 0.0349483745047778 0.9965042778577364 0.1424818345194788 40 P55011,P61421,P05026,Q15904,Q9C0H2,Q9Y487,Q9UM00,P54709,O96008,P51790,Q93050,Q9H2J7,Q658P3 13 +Sphingolipid metabolism 0.8761490268244538 1.9606235394639264 0.0499229543477923 0.9997091605965552 0.1804034032113406 7 P17900,P04062,Q13510 3 +Immunity 0.4827393768496912 1.89799132284939 0.0576972250871778 0.9999212438030668 0.1932202738559282 68 Q13501,O75179,O00584,Q07021,P10321,Q9UQ84,Q8IV08,Q9NUD5,P01889,Q12899 10 +Lipid transport 0.6486032006944555 1.847255207008844 0.0647101615369796 0.9999759868941824 0.2057783136875952 18 P61916,Q14849,O15118 3 +Amino-acid transport 0.8775054775272595 1.7776462313636794 0.0754619757268906 0.9999961802088588 0.2307395027033771 4 Q9H2J7 1 +Endocytosis 0.5734488883101428 1.7275807488137245 0.0840634166980249 0.9999991358294368 0.2487171783460636 25 P05067,Q99523,P02786 3 +Sodium transport 0.833277720783636 1.632428691037821 0.1025892091380773 0.999999966456012 0.2861698991746368 5 P55011,Q9H2J7,P05026 3 +Chemotaxis 0.8302040816326511 1.599329143739696 0.109747487160756 0.999999990611416 0.3008594906648311 3 O94813,P26583 2 +Notch signaling pathway 0.8185863998459193 1.5636304562067134 0.1179043781634998 0.999999997827344 0.3177423072541776 6 P05067 1 +Tyrosine catabolism 0.7258261933904564 1.545336580807595 0.1222648715783043 0.9999999990119172 0.3186904029663998 2 P16930 1 +Phenylalanine catabolism 0.7258261933904564 1.545336580807595 0.1222648715783043 0.9999999990119172 0.3186904029663998 2 P16930 1 +Potassium transport 0.7792865912129832 1.40178461001335 0.1609795755258847 0.9999999999992416 0.3999336329471198 4 P55011,P05026 2 +Neurogenesis 0.461838525018843 1.286298515076339 0.1983389005381759 0.9999999999999994 0.4706848535159697 39 P55209,Q8WUJ1,O94813,Q96EK5,Q15375 5 +Cholesterol biosynthesis 0.6067126074639021 1.267559212063944 0.2049554056071776 1.0 0.4792339631109006 10 Q15392,Q9UBM7 2 +Sterol biosynthesis 0.574644066016555 1.1604530783992235 0.2458643869784398 1.0 0.5355514271117393 11 Q15392,Q9UBM7 2 +Sodium/potassium transport 0.7183053883754241 1.160409546632847 0.2458821017557042 1.0 0.5355514271117393 3 P05026 1 +Innate immunity 0.4231657410904308 1.0928228225000391 0.2744715990942699 1.0 0.5818797900798521 52 O75179,O00584,Q07021,P10321,Q9NUD5,Q12899 6 +Apoptosis 0.3800454653110594 1.0607745771263843 0.2887923584383396 1.0 0.5963374674246233 95 Q13501,P05067,Q9BZZ5,Q6FI81,Q9UHX1,Q07021,Q9Y3E7,Q9NXR7,Q15375,Q03164,O43464,Q66K74,Q5J8M3,O95831,Q658P3 15 +Symport 0.666512815381703 0.9973011971124448 0.318618332843577 1.0 0.6242814008823624 5 Q9H2J7 1 +Lipid metabolism 0.3754673665711767 0.9773548953706712 0.3283934847307368 1.0 0.6290911333998452 92 P35790,Q99519,Q15185,Q8NHP8,Q9UBM7,Q9UHB6,P61916,O15118,P17900,Q15392,P04062,P38571,O15269,Q14739,Q13510 15 +Exocytosis 0.5004932652660629 0.8253826071068806 0.4091544062572667 1.0 0.6920803254777171 11 P11233,P51809,Q9BRK5 3 +Hydrogen ion transport 0.438281887840775 0.7259789644301077 0.4678516662422241 1.0 0.7381357913944802 18 Q93050,Q15904,Q9Y487 3 +Necrosis 0.5928070401263108 0.7243046705315791 0.468878710256871 1.0 0.7381357913944802 5 Q96HS1,Q13546 2 +Adaptive immunity 0.4379650151583846 0.6159640797041143 0.5379182273594338 1.0 0.7636517691977678 14 P09429,Q07021,P10321,P01889,Q6P179,Q03519 6 +Carbohydrate metabolism 0.3944037491997361 0.5779186828126276 0.5633190211101047 1.0 0.7774187383025329 22 Q99519,Q8NCH0,O60701 3 +Steroid biosynthesis 0.4214579612297575 0.5650160532938959 0.5720628451660148 1.0 0.7774187383025329 15 Q15392,Q9UBM7 2 +Host-virus interaction 0.3450115074844674 0.4670439711217097 0.6404684190130172 1.0 0.8279225904314612 214 Q9H3P7,Q92692,P02786,O43760,Q13573,O95373,Q14108,P11279,Q8WTV0,P25440,O15118,P05556,P49721,P10321,Q7Z739,P01889,Q9Y624,Q03519,P28072,O75179,Q9P032,Q07021,P29083,Q15056,Q93034,Q01105,Q92688,P35613 28 +Unfolded protein response 0.5015130880603904 0.4219380026227091 0.6730702705776495 1.0 0.8570782270487242 6 Q13217 1 +Lipid biosynthesis 0.3437212162066287 0.419830203054588 0.67460949909115 1.0 0.8570782270487242 40 P35790,Q15185,P38398,Q9UG56,Q9UBM7,Q96G23,Q15392,Q14739 8 +Differentiation 0.3238482144436685 0.4022194514823573 0.6875225281225652 1.0 0.8570782270487242 68 Q13501,Q96EP5,Q9BW83,Q96A49,P15531,O94813,Q99523,Q96EK5,Q7Z6Z7,P51114,Q16527,Q96PU8 12 +Isoprene biosynthesis 0.451652386780903 0.3899858395092545 0.696547018007847 1.0 0.8570782270487242 2 P14324 1 +Glycogen metabolism 0.479471099069683 0.3569589059226607 0.7211225700522679 1.0 0.8570782270487242 6 P31751,P06737 2 +Phospholipid biosynthesis 0.3909645194891343 0.345724739558118 0.7295495899898614 1.0 0.8570782270487242 9 P35790 1 +Cell shape 0.4720757066578516 0.3361295804278624 0.7367731528847186 1.0 0.8570782270487242 6 Q96AC1,P35579 2 +Phospholipid metabolism 0.3462407196950687 0.208835408915299 0.8345767284092667 1.0 0.9411184384189604 10 P35790 1 +Myogenesis 0.378571317275986 0.1240277545187153 0.9012932997965593 1.0 0.974868263045258 5 P51114 1 +Wnt signaling pathway 0.3054953745503433 0.107914886436978 0.914063208415532 1.0 0.9820003387707404 16 P67870,P48729 2 +Branched-chain amino acid catabolism 0.3280293757649926 0.09966632361784 0.9206092372406048 1.0 0.9823950920889676 2 P31937 1 +DNA condensation 0.3259803921568649 0.056467700596252 0.9549692256445204 1.0 1.0 5 Q15021,Q9NTJ3,O95347,Q9BPX3 4 +Pyrimidine biosynthesis 0.3144587166204836 0.0462223600228152 0.9631330207983108 1.0 1.0 5 Q9NRF8 1 +Translocation 0.2859143676342539 0.0329331216174765 0.973727919882944 1.0 1.0 43 Q9NS69,Q99595,Q9NPA8,O14925,O60830,Q5SRE5 6 diff --git a/protein_atlas_biological_process/selections.json b/protein_atlas_biological_process/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..fc64d117608479c5525d48957bd33f7295913331 --- /dev/null +++ b/protein_atlas_biological_process/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthesis", "Adaptive immunity", "Amino-acid biosynthesis", "Amino-acid transport", "Angiogenesis", "Antiport", "Antiviral defense", "Apoptosis", "Arginine metabolism", "Aromatic hydrocarbons catabolism", "Asparagine biosynthesis", "Autophagy", "B-cell activation", "Biological rhythms", "Biomineralization", "Branched-chain amino acid biosynthesis", "Branched-chain amino acid catabolism", "Calcium transport", "Carbohydrate metabolism", "Catecholamine metabolism", "Cell adhesion", "Cell cycle", "Cell division", "Cell shape", "Chemotaxis", "Cholesterol biosynthesis", "Cholesterol metabolism", "Chromosome partition", "Cilium biogenesis/degradation", "Coenzyme A biosynthesis", "Collagen degradation", "Complement pathway", "DNA condensation", "DNA damage", "DNA excision", "DNA recombination", "DNA repair", "DNA replication", "DNA synthesis", "Detoxification", "Differentiation", "ER-Golgi transport", "Electron transport", "Endocytosis", "Exocytosis", "Fatty acid biosynthesis", "Fatty acid metabolism", "Fertilization", "GMP biosynthesis", "GPI-anchor biosynthesis", "Galactose metabolism", "Gastrulation", "Gluconate utilization", "Gluconeogenesis", "Glucose metabolism", "Glutathione biosynthesis", "Glycogen biosynthesis", "Glycogen metabolism", "Glycolysis", "Glyoxylate bypass", "Growth arrest", "Growth regulation", "Hearing", "Heme biosynthesis", "Host-virus interaction", "Hydrogen ion transport", "Hypusine biosynthesis", "Immunity", "Inflammatory response", "Inhibition of host STAT1 by virus", "Inhibition of host STAT2 by virus", "Inhibition of host innate immune response by virus", "Inhibition of host interferon signaling pathway by virus", "Innate immunity", "Inositol biosynthesis", "Ion transport", "Iron transport", "Isoprene biosynthesis", "Leukotriene biosynthesis", "Lipid biosynthesis", "Lipid degradation", "Lipid metabolism", "Lipid transport", "Meiosis", "Methionine biosynthesis", "Methotrexate resistance", "Mitosis", "Myogenesis", "Necrosis", "Neurogenesis", "Neurotransmitter degradation", "Neurotransmitter transport", "Nonsense-mediated mRNA decay", "Notch signaling pathway", "Nucleotide biosynthesis", "Nucleotide metabolism", "One-carbon metabolism", "Oogenesis", "Osteogenesis", "Pentose shunt", "Peptide transport", "Phagocytosis", "Phenylalanine catabolism", "Phospholipid biosynthesis", "Phospholipid metabolism", "Plasminogen activation", "Polyamine biosynthesis", "Porphyrin biosynthesis", "Potassium transport", "Proline biosynthesis", "Prostaglandin biosynthesis", "Prostaglandin metabolism", "Protein biosynthesis", "Protein transport", "Purine biosynthesis", "Purine salvage", "Pyridine nucleotide biosynthesis", "Pyrimidine biosynthesis", "RNA-mediated gene silencing", "Respiratory chain", "Ribosome biogenesis", "Sensory transduction", "Serine biosynthesis", "Sodium transport", "Sodium/potassium transport", "Spermatogenesis", "Spermidine biosynthesis", "Sphingolipid metabolism", "Steroid biosynthesis", "Steroid metabolism", "Sterol biosynthesis", "Sterol metabolism", "Stress response", "Sugar transport", "Symport", "Transcription", "Transcription regulation", "Transcription termination", "Translation regulation", "Translocation", "Transport", "Tricarboxylic acid cycle", "Tyrosine catabolism", "Ubl conjugation pathway", "Unfolded protein response", "Urea cycle", "Viral RNA replication", "Viral immunoevasion", "Viral penetration into host nucleus", "Virus entry into host cell", "Vision", "Wnt signaling pathway", "Xylose metabolism", "mRNA capping", "mRNA processing", "mRNA splicing", "mRNA transport", "rRNA processing", "tRNA processing"], "available_proteins": ["AAAS", "AARS", "AARS2", "AARSD1", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABHD12", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOX1", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN4", "ACTR3", "ADAM17", "ADAR", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AKAP17A", "AKAP8L", "AKT2", "ALDH18A1", "ALDH3A2", "ALDOA", "ALDOC", "ALKBH5", "ANAPC1", "ANAPC16", "ANAPC5", "ANAPC7", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "ANXA1", "ANXA11", "ANXA2", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEX1", "API5", "APOL2", "APOO", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARG2", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL2", "ARL3", "ARL6IP1", "ARMT1", "ASAH1", "ASNA1", "ASNS", "ATAD5", "ATG4B", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "AUP1", "BABAM1", "BABAM2", "BAG6", "BANF1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCL2L12", "BCLAF1", "BIRC6", "BLM", "BMS1", "BOP1", "BPTF", "BRCA1", "BRD2", "BRIX1", "BRMS1L", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BYSL", "BZW1", "C12orf43", "C1QBP", "CACYBP", "CAD", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAPRIN1", "CARM1", "CARS", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC86", "CD2AP", "CD3EAP", "CDC123", "CDC23", "CDC27", "CDC34", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKAL1", "CEBPZ", "CELF1", "CERS2", "CFL1", "CHAF1B", "CHCHD3", "CHD4", "CHID1", "CHKA", "CHMP3", "CHMP7", "CHORDC1", "CHST14", "CHTF18", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP5", "CLASP1", "CLASP2", "CLCN3", "CLIC1", "CLINT1", "CLPTM1", "CLTC", "CMPK1", "CMTR1", "CNNM4", "CNOT1", "CNOT10", "CNOT3", "CNOT6", "CNOT7", "CNOT9", "COG7", "COMMD2", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS6", "COPS7A", "COPZ1", "COX2", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CRNKL1", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2B", "CSRP2", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CWC15", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF13", "DCAF7", "DCPS", "DCTN1", "DCTN3", "DCXR", "DDB1", "DDRGK1", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX46", "DDX47", "DDX5", "DDX51", "DDX54", "DDX56", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLST", "DNAAF5", "DNAJA3", "DNAJB1", "DNAJC2", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPF2", "DPYSL2", "DSG2", "DST", "DTYMK", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "EBNA1BP2", "ECH1", "ECHS1", "ECSIT", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "EMC4", "EMG1", "EML4", "ENO1", "ENSA", "ENY2", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERH", "ERLIN2", "ERO1A", "ERP44", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAM120B", "FAM162A", "FAM208A", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP8", "FLII", "FLNA", "FLNB", "FLOT2", "FMR1", "FOXC1", "FOXK1", "FRG1", "FTSJ3", "FUBP1", "FUBP3", "FXR1", "G3BP1", "G3BP2", "G6PD", "GADD45GIP1", "GAK", "GALK1", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GBA", "GBF1", "GCC2", "GCN1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GINS1", "GINS4", "GLE1", "GM2A", "GMPS", "GNAI2", "GNAI3", "GNL2", "GNL3L", "GNPDA1", "GOLIM4", "GORASP2", "GOT1", "GOT2", "GPAA1", "GPI", "GRB2", "GRIPAP1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSS", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP10", "GTPBP3", "GTPBP4", "GYS1", "H2AFX", "HACD3", "HADH", "HADHA", "HADHB", "HAUS5", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HELLS", "HERC2", "HIBADH", "HIBCH", "HIC2", "HIF1AN", "HINT2", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH3", "HNRNPK", "HNRNPM", 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https://git-lfs.github.com/spec/v1 +oid sha256:ae5e6a7a8b508c0c14b5ff6899f0a2a9a33630c950e73ded15e1e29e977ef6a0 +size 67338 diff --git a/protein_atlas_disease_involvement/df_merge.tsv b/protein_atlas_disease_involvement/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..2e18d860ef1d2b3a09eda66b77799d6a37def8a6 --- /dev/null +++ b/protein_atlas_disease_involvement/df_merge.tsv @@ -0,0 +1,3 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 +Neurodegeneration 14 107 3.322806759894541 0.0008911662587085 27.95631067961165 134.69660194174756 0.269943056894121 0.615157984625689 9.104465669482156 13.994023970959963 0.954862652984542 0.3632698211987682 8.938086723003522e-05 6.350793990316081e-06 0.0064039869836025 0.0348404467407174 +Mucopolysaccharidosis 4 5 1.9660084521602823 0.049297634282126 2.254854368932039 4.752427184466019 0.4843930061917075 0.2034155563537636 0.9831595235232706 0.7286567852681505 1.626107445717624 0.2463507210616131 0.0012601973854463 2.7271245685342773e-06 3.419148340727646e-06 9.8492817269125e-05 diff --git a/protein_atlas_disease_involvement/metrics.json b/protein_atlas_disease_involvement/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..fc65ece9371cba4aa84d3e3e33bf5f90ff29bd6a --- /dev/null +++ b/protein_atlas_disease_involvement/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2453, + "annotations_size": 108, + "title": "Average number of proteins per term", + "value": 18.583333333333332 +} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/paths.json b/protein_atlas_disease_involvement/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..a2cdb54ffaa265c7bea76fabe841e38946626dce --- /dev/null +++ b/protein_atlas_disease_involvement/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_disease_involvement/fragment/C334/C334_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/result.tsv b/protein_atlas_disease_involvement/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..048062449304ecf89d98eaf5636bb62a064c0d64 --- /dev/null +++ b/protein_atlas_disease_involvement/result.tsv @@ -0,0 +1,30 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Neurodegeneration 0.5660439534440458 3.3228067598945414 0.0008911662587085 0.0917983713164858 0.0149647245456567 107 Q13501,P05067,P06865,O75503,P07686,Q8IV08,O14773,P04062,P50897,P54802,O43464,Q14108,O15269,Q13510 14 +Niemann-Pick disease 0.9812321501427994 2.6453145553576793 0.0081615008789004 0.5873100654151725 0.0801310995382952 2 P61916 1 +Hirschsprung disease 0.9555283557731552 2.5395861740620314 0.0110983700600932 0.7004053782696398 0.0949370846492592 2 P42892 1 +Neuronal ceroid lipofuscinosis 0.9820408163265304 2.179884156671267 0.0292660496181134 0.9595588368120512 0.1319738817441566 3 P50897,O75503 2 +Gangliosidosis 0.9840751327072272 2.1740933379332943 0.0296981261955568 0.9614573148105 0.1319738817441566 4 P06865,P17900,P16278 3 +Mucopolysaccharidosis 0.9227941176470588 1.9660084521602823 0.049297634282126 0.995745837672932 0.1717465968538586 5 P08236,P54802,P16278,P15586 4 +Ehlers-Danlos syndrome 0.8857141218647078 1.814572981927849 0.069589557674154 0.9995861392821034 0.2087686730224622 3 Q9NWM8 1 +Spinocerebellar ataxia 0.7795800333454606 1.7746243920866451 0.0759599269374664 0.9998029361223753 0.2135516660197914 8 Q8IV08 1 +Parkinsonism 0.7023771028574652 1.461539025527432 0.1438675738268064 0.9999999481889724 0.3297724811506483 8 P04062,Q14203,O43464 3 +Parkinson disease 0.7423416176102404 1.4466061782398254 0.1480072548502815 0.9999999693043492 0.3297724811506483 7 P04062 1 +Disease variant 0.3262407249063524 1.44210616384083 0.1492724264765901 0.9999999738558216 0.3297724811506483 635 P05067,O00584,O75503,P06280,Q8IV08,P61916,P02786,P10253,P17900,P42892,P50897,O43505,Q14108,P16278,P15586,P06865,Q99519,Q15904,P07686,P10619,O14773,O15118,P54802,Q92542,P38571,Q13510,Q13501,O43772,Q9UBM7,Q14126,Q15392,P04062,P08236,Q9H2D1,O15269,Q14739,Q07021,P67870,Q01105,O43464,Q96C86,O95831 42 +Epilepsy 0.4203600703824335 1.0693296458230757 0.2849211566662823 0.9999999999999998 0.5398506126308508 52 Q5MNZ6,O75503,P67870,O14773,Q8NC96,O43464,Q9ULM3,Q14108,Q13510 9 +Cushing syndrome 0.6631996494922532 0.9554179012262812 0.3393664048300859 1.0 0.5737969764030323 4 P17612,O00170 2 +FDA approved drug targets 0.3718634578843461 0.9479337257383552 0.3431631943893003 1.0 0.5737969764030323 93 P55011,P05067,Q13547,P49721,Q9Y2I1,P49069,Q02880,P02786,P42345,Q13423,P10253,P20020,P05556,P49356 14 +Congenital disorder of glycosylation 0.4938090725439389 0.8207723243595944 0.4117759655561954 1.0 0.6276628695190046 12 Q10471,Q15904 2 +Limb-girdle muscular dystrophy 0.6116910360356738 0.7928661700626989 0.4278557992482819 1.0 0.6383834837167571 5 Q7Z392,O14979 2 +Holoprosencephaly 0.5157078743370053 0.625727557168465 0.5314936549607399 1.0 0.7454716199449339 2 Q8N3U4 1 +Williams-Beuren syndrome 0.5171774007091429 0.5792651210199038 0.5624102962879385 1.0 0.7624563502383849 7 Q15056 1 +Amyotrophic lateral sclerosis 0.4365094710555824 0.5653403880832752 0.5718422626787887 1.0 0.7624563502383849 12 Q13501,P35637 2 +Charcot-Marie-Tooth disease 0.3815167985712197 0.4562994564492253 0.648174654757639 1.0 0.8192906737555743 19 P54802 1 +Craniosynostosis 0.4679722562219589 0.4458389732085778 0.6557135673564976 1.0 0.8192906737555743 2 P16435 1 +Proto-oncogene 0.3401634029607149 0.3191468160337647 0.7496151843077654 1.0 0.8834547560252879 34 P35637,Q9BZH6,Q12802,Q01844,Q92804,Q01105,Q03164 7 +Ichthyosis 0.3972287210621893 0.2806804764130475 0.778955484594009 1.0 0.8834547560252879 8 P04062 1 +Autism 0.4630594254415174 0.2777251017888663 0.7812233898988374 1.0 0.8834547560252879 3 P27635 1 +Autism spectrum disorder 0.3517533630156489 0.2253539063168717 0.8217039667917223 1.0 0.8967088459503266 10 Q05639,P27635,Q02880,Q9H2P0 4 +Schizophrenia 0.3749490004079925 0.1795085743850316 0.8575383852974285 1.0 0.9261414561212228 2 Q9NTZ6 1 +Systemic lupus erythematosus 0.3983673469387722 0.1430305872122432 0.8862660244397216 1.0 0.9476904023711874 3 P05455,P12956 2 +Neuropathy 0.2896342730434486 0.0632300182908862 0.949583341458644 1.0 0.9861057776685918 40 O95721,Q14203,Q13217,P54802,O95831,O15269 6 +Primary microcephaly 0.2809137664884495 0.0371202695665408 0.9703891103880568 1.0 0.9910233265017404 8 Q8NFH4 1 diff --git a/protein_atlas_disease_involvement/selections.json b/protein_atlas_disease_involvement/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..8caa46c6ddb7002f42ad6a16b126685013bd8ac6 --- /dev/null +++ b/protein_atlas_disease_involvement/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Aicardi-Goutieres syndrome", "Albinism", "Allergen", "Alport syndrome", "Alzheimer disease", "Amelogenesis imperfecta", "Amyloidosis", "Amyotrophic lateral sclerosis", "Atrial fibrillation", "Autism", "Autism spectrum disorder", "Bardet-Biedl syndrome", "Bartter syndrome", "Cancer-related genes", "Cardiomyopathy", "Cataract", "Charcot-Marie-Tooth disease", "Ciliopathy", "Cockayne syndrome", "Cone-rod dystrophy", "Congenital adrenal hyperplasia", "Congenital disorder of glycosylation", "Congenital hypothyroidism", "Congenital muscular dystrophy", "Congenital myasthenic syndrome", "Craniosynostosis", "Cushing syndrome", "Deafness", "Diabetes insipidus", "Diabetes mellitus", "Diamond-Blackfan anemia", "Disease variant", "Dwarfism", "Dyskeratosis congenita", "Dystonia", "Dystroglycanopathy", "Ectodermal dysplasia", "Ehlers-Danlos syndrome", "Elliptocytosis", "Emery-Dreifuss muscular dystrophy", "Epidermolysis bullosa", "Epilepsy", "FDA approved drug targets", "Fanconi anemia", "Gangliosidosis", "Gaucher disease", "Glaucoma", "Glutaricaciduria", "Glycogen storage disease", "Gout", "Hereditary hemolytic anemia", "Hereditary nonpolyposis colorectal cancer", "Hereditary spastic paraplegia", "Hermansky-Pudlak syndrome", "Hirschsprung disease", "Holoprosencephaly", "Hypogonadotropic hypogonadism", "Hypotrichosis", "Ichthyosis", "Intrahepatic cholestasis", "Joubert syndrome", "Kallmann syndrome", "Kartagener syndrome", "Leber congenital amaurosis", "Leigh syndrome", "Leukodystrophy", "Li-Fraumeni syndrome", "Limb-girdle muscular dystrophy", "Lissencephaly", "Meckel syndrome", "Mental retardation", "Microphthalmia", "Mucopolysaccharidosis", "Myofibrillar myopathy", "Nemaline myopathy", "Nephronophthisis", "Neurodegeneration", "Neuronal ceroid lipofuscinosis", "Neuropathy", "Niemann-Pick disease", "Non-syndromic deafness", "Obesity", "Oncogene", "Osteogenesis imperfecta", "Palmoplantar keratoderma", "Parkinson disease", "Parkinsonism", "Peroxisome biogenesis disorder", "Peters anomaly", "Pontocerebellar hypoplasia", "Premature ovarian failure", "Primary ciliary dyskinesia", "Primary hypomagnesemia", "Primary microcephaly", "Primary mitochondrial disease", "Progressive external ophthalmoplegia", "Proto-oncogene", "Pyropoikilocytosis", "Retinitis pigmentosa", "Rhizomelic chondrodysplasia punctata", "SCID", "Schizophrenia", "Spinocerebellar ataxia", "Systemic lupus erythematosus", "Tumor suppressor", "Williams-Beuren syndrome", "Xeroderma pigmentosum", "Zellweger syndrome"], "available_proteins": ["AAAS", "AARS", "AARS2", "ABCB1", "ABCB7", "ABHD12", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACLY", "ACO1", "ACO2", "ACOX1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ADAR", "ADD3", "ADK", "ADNP", "ADPRHL2", "ADSL", "AFDN", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP12", "AKAP13", "AKR1B1", "AKT2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ANAPC1", "ANK3", "ANKLE2", "ANLN", "ANXA1", "ANXA11", "ANXA2", "ANXA7", "AP1B1", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "APEX1", "APOL2", "APP", "APRT", "ARCN1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARL2", "ARL3", "ARL6IP1", "ARPC1B", "ASAH1", "ASNS", "ASPH", "ATAD1", "ATAD3A", "ATIC", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP6AP1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATXN10", "B4GAT1", "BANF1", "BAZ1B", "BCAP31", "BCAT2", "BCLAF1", "BIRC6", "BLM", "BLMH", "BMS1", "BPTF", "BRCA1", "BRI3BP", "BUB1B", "BUD23", "C19orf70", "C1QBP", "CAD", "CALR", "CAMK2G", "CAMLG", "CANX", "CAPN1", "CARM1", "CARS", "CAST", "CCAR1", "CCAR2", "CCDC47", "CCDC6", "CCT5", "CDC27", "CDC34", "CDC37", "CDC42", "CDC73", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CFL2", "CHAMP1", "CHD4", "CHST14", "CISD2", "CIZ1", "CKB", "CKMT1A*", "CLIC1", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNNM4", "CNOT1", "CNOT3", "COA3", "COA7", "COG7", "COLGALT1", "COMT", "COPA", "COPB2", "COX2", "COX4I1", "COX5A", "CPOX", "CPSF1", "CPT2", "CRTAP", "CSDE1", "CSE1L", "CSNK2B", "CSTB", "CTBP1", "CTNNB1", "CTNNBL1", "CTNND1", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWF19L1", "CYB5R3", "CYC1", "CYP51A1", "DAD1", "DARS", "DARS2", "DBN1", "DCPS", "DCTN1", "DDOST", "DDRGK1", "DDX10", "DDX3X", "DDX41", "DDX5", "DDX6", "DEK", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHX16", "DHX30", "DHX37", "DHX38", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DIS3", "DKC1", "DLD", "DLST", "DNAAF5", "DNAJB1", "DNAJC2", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPF2", "DPM1", "DSG2", "DSP", "DST", "DYNC1H1", "DYNC1I2", "DYNLL1", "ECE1", "ECHS1", "EDC3", "EEF1A2", "EEF2", "EFL1", "EFTUD2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S2", "EIF3E", "EIF3F", "EIF3H", "EIF4A2", "EIF4A3", "EIF4E", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELP1", "ELP2", "EMC1", "EMD", "EMG1", "EML4", "ENO1", "EPB41", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERC1", "ERCC2", 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"MRPS34", "MRPS7", "MSH2", "MSH6", "MSI2", "MSN", "MTA1", "MTOR", "MTPAP", "MTR", "MYH10", "MYH14", "MYH9", "MYO6", "NAA15", "NAGLU", "NAMPT", "NANS", "NAXE", "NCAPD2", "NCAPH", "NCSTN", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFB11", "NDUFB3", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NEDD4L", "NEFL", "NEK9", "NEU1", "NHLRC2", "NHP2", "NIPBL", "NISCH", "NME1", "NNT", "NONO", "NOP56", "NPC1", "NPC2", "NPM1", "NSD2", "NSDHL", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NUCB2", "NUDT1", "NUMA1", "NUP107", "NUP133", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP37", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "OAT", "OCLN", "OGDH", "OGT", "OPA1", "OPA3", "P3H1", "P4HA2", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PARK7", "PARN", "PARP1", "PARP2", "PBRM1", "PC", "PCBP1", "PCCA", "PCCB", "PCM1", "PCNA", "PDCD4", "PDHA1", "PDHB", "PDK3", "PEPD", "PEX14", "PFKM", "PFN1", "PGK1", "PGM1", "PGM3", "PHB", 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"VPS33B", "VPS35", "VPS51", "VPS53", "VRK1", "WARS", "WDR1", "WDR11", "WDR36", "WDR4", "WDR45B", "WDR5", "WFS1", "WRAP53", "XPO1", "XRCC1", "XRCC5", "XRCC6", "YARS", "YARS2", "YBX1", "YEATS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAZ", "ZC3H14", "ZCCHC8", "ZMPSTE24", "ZMYM2", "ZNF148"], "leading_proteins": ["ADNP", "AIFM1", "AIP", "AKAP13", "APP", "ASAH1", "ATP2B1", "ATP6AP1", "B4GAT1", "C1QBP", "CAMLG", "CLN5", "CSNK2B", "CTSA", "DCPS", "DCTN1", "DHCR24", "DHCR7", "DNAJC3", "DSG2", "ECE1", "EEF1A2", "EIF4H", "EWSR1", "FKBP14", "FNTB", "FUS", "GAA", "GALNT2", "GBA", "GLA", "GLB1", "GM2A", "GNS", "GUSB", "HDAC1", "HEXA", "HEXB", "HNRNPDL", "HTRA2", "ITGB1", "KMT2A", "LBR", "LIPA", "MTOR", "NAGLU", "NCSTN", "NECAP1", "NEU1", "NISCH", "NNT", "NPC1", "NPC2", "NUP37", "PLD3", "POR", "PPT1", "PRKACA", "PSMB2", "RBM12", "RNASET2", "RPL10", "SCARB2", "SET", "SLC12A2", "SLC25A20", "SLC25A32", "SNAP29", "SPTLC1", "SQSTM1", "SSB", "STAG2", "TAF15", "TFRC", "TOP2B", "TPP1", "TRAPPC11", 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a/protein_atlas_molecular_function/df_merge.tsv b/protein_atlas_molecular_function/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..2ea3899fbd898b91ca2fffa6cabe102a7b76805f --- /dev/null +++ b/protein_atlas_molecular_function/df_merge.tsv @@ -0,0 +1,9 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 +Protease 11 70 3.1103378789120644 0.0018687344766197 20.788834951456312 82.44417475728156 1.1215350835872162 0.3507517256058336 6.07090559629836 8.079357013764625 1.4678877461728397 0.3691345771929886 1.4076449696608436e-05 0.0004141157726374 0.0042179963634048 0.0976681759179421 +Receptor 11 30 3.019506731242488 0.0025318666680713 13.475728155339803 38.71116504854369 1.6655960679271569 0.1791616261110447 5.431559450288914 6.105192092581698 1.9169648296245776 0.2753083483896962 0.0001988835377557 0.000163724242627 0.0032921180030238 0.0640183875781768 +Hydrolase 34 309 2.952453738949846 0.0031525930440741 64.97087378640776 381.1650485436893 -0.1426199141915242 0.6734352746482181 21.484790877323487 36.07841973574662 1.159823788317903 0.3763062344575927 5.004544076297643e-10 5.292437679448305e-09 0.0002655814592617 0.0157229263816104 +Glycosidase 9 15 2.87660318957524 0.0040198073946287 7.798543689320389 18.135922330097088 0.5112745472223946 0.1951515073440806 2.9064203812520417 1.9684331341643595 1.9501681029822375 0.2619382904734375 1.2420126183560555e-09 7.634171089938876e-12 5.946855875018689e-08 3.149462060172679e-05 +Host cell receptor for virus entry 8 14 2.773786360117398 0.0055408051826111 4.509708737864078 15.157766990291265 0.7214109752050332 0.2527966464979699 2.499010078306418 1.9009100692398744 1.5211756979359785 0.2791170769282048 1.7142977313219222e-06 3.0169526186138405e-06 5.898054340284301e-07 0.0001547469331586 +Protease inhibitor 1 7 2.0463750405871703 0.0407194858118593 2.679611650485437 6.827669902912621 -0.1389909380340853 0.4401686430319619 1.73744367643855 1.203518872907143 1.1014803254493444 0.2988298098237953 0.0065792573185243 0.0246740936940832 0.123579290468326 0.1204887281128287 +Carboxypeptidase 4 6 2.033352606458138 0.0420169118694593 3.1359223300970873 6.150485436893204 0.9957728306848488 0.1212034427500092 1.2071674596015187 0.4479454254223922 1.8250051834990677 0.2074401112551974 6.712740949068952e-07 1.094486762177302e-05 2.050947898007762e-05 0.000543833852376 +Metalloprotease 2 24 2.001989750862305 0.0452858338390138 8.160194174757281 26.429611650485437 1.390302281711237 0.2661274848815638 3.192614043118206 1.543038499308978 1.1108461579919544 0.309446154241223 0.0028326312129738 0.0191373699896123 0.0133513277547448 0.0221489740322384 diff --git a/protein_atlas_molecular_function/metrics.json b/protein_atlas_molecular_function/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..5bbd2dc5476cefffea4189531a2738069d341f0e --- /dev/null +++ b/protein_atlas_molecular_function/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2453, + "annotations_size": 93, + "title": "Average number of proteins per term", + "value": 32.784946236559136 +} \ No newline at end of file diff --git a/protein_atlas_molecular_function/paths.json b/protein_atlas_molecular_function/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..4d0ad2dc7ded522b261ac6ede2274d4da2914df6 --- /dev/null +++ b/protein_atlas_molecular_function/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_molecular_function/fragment/C334/C334_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_molecular_function/result.tsv b/protein_atlas_molecular_function/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..4a75282c1a4f9f057395c5ae8e7eef40e9ab38fa --- /dev/null +++ b/protein_atlas_molecular_function/result.tsv @@ -0,0 +1,27 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Protease 0.6225422982402953 3.1103378789120644 0.0018687344766197 0.1596651996858905 0.0193102562584038 70 Q9HB40,Q9UIQ6,P10619,Q99538,O14773,P42785,P42892,O75976,O43464,P28072,Q9H3G5 11 +Receptor 0.777030787506266 3.019506731242488 0.0025318666680713 0.2100314823909568 0.0214057818300579 30 P11279,Q8WTV0,Q99523,P02786,O15118,Q9Y624,Q15375,P11717,Q14108,P35613,Q14739 11 +Hydrolase 0.4741737851791335 2.952453738949846 0.0031525930440741 0.2544658092037209 0.0228700025665011 309 Q9HB40,O00584,Q8NHP8,Q9UIQ6,P06280,P11117,Q8IV08,Q99538,Q9BTY2,P10253,P17900,P42892,P50897,O75976,Q9H3G5,P16278,P15586,P06865,Q99519,P07686,P10619,O14773,Q92820,P54802,P38571,Q13510,Q9UQ84,O00148,P04062,P08236,P28072,P11233,P42785,O43464 34 +Glycosidase 0.9106391601645398 2.8766031895752397 0.0040198073946287 0.3124326523387825 0.0267030062643192 15 P06865,Q99519,P06280,P07686,Q9BTY2,P10253,P04062,P54802,P16278 9 +Host cell receptor for virus entry 0.9041970127181213 2.773786360117398 0.0055408051826111 0.403530846663153 0.034352992132189 14 P11279,Q8WTV0,Q92692,P02786,O15118,Q9Y624,Q14108,P35613 8 +Prenyltransferase 0.8833129334965333 2.2361855870368887 0.0253396169296966 0.908090971880205 0.1178292187230894 2 Q92696 1 +Serine protease inhibitor 0.9594301747051136 2.083688862914197 0.037188477925905 0.9705327955515204 0.1503708020482248 4 P05067 1 +Protease inhibitor 0.899083626255051 2.0463750405871703 0.0407194858118593 0.9790616277459449 0.1563029121543887 7 P05067 1 +Carboxypeptidase 0.9474684687621898 2.033352606458138 0.0420169118694593 0.9815379751281303 0.1563029121543887 6 Q9HB40,P10619,Q9H3G5,O75976 4 +Metalloprotease 0.6220669229624943 2.0019897508623052 0.0452858338390138 0.9865654505739532 0.1619839441164726 24 P42892,Q9UIQ6 2 +Heparin-binding 0.908351860734022 1.892832203606692 0.0583801874832072 0.9962809700811436 0.1906318218487223 6 P05067 1 +Nuclease 0.5825939692361732 1.869925702056364 0.061494136080233 0.9972669969489492 0.1906318218487223 30 Q8IV08,Q9UQ84,O00584,Q9Y2L1 4 +Exonuclease 0.6205886773962775 1.7019799750033853 0.0887591222037358 0.9998238482275936 0.2662773666112075 18 Q9UQ84,Q8IV08,Q9Y2L1 3 +Glycosyltransferase 0.5580881930589162 1.634627949895009 0.1021270647843648 0.99995543602652 0.2926146467287824 25 Q13126,Q10472,P04062,O43505 4 +Endonuclease 0.6473692093663851 1.6265580090583869 0.103831003677955 0.999962652451327 0.2926146467287824 14 Q9UQ84,O00584 2 +Aminopeptidase 0.6133573180989684 1.3359280902226889 0.1815727784868619 0.999999991924933 0.4041772146530481 11 Q9UIQ6 1 +Serine protease 0.6300864030333982 1.3330004829073554 0.182531645327183 0.999999992759004 0.4041772146530481 9 O14773 1 +Tumor antigen 0.674418604651168 1.3143239161352576 0.1887372222582815 0.9999999964352904 0.4081991086051204 2 Q96RS6 1 +Developmental protein 0.390276201607282 0.991969183295804 0.3212125584316951 0.9999999999999998 0.5974553586829531 66 Q8IXK0,O94813,Q99523,Q68CQ4,Q96EK5,Q8NB78,Q69YN4,Q15375,P31751,Q9UNS1,P51114,Q16527,Q9BX40,Q9Y263,Q96PU8 15 +Elongation factor 0.4958341185639865 0.8046243605619676 0.4210364801762538 1.0 0.6992212974355644 11 Q05639,Q9Y450,P26641,P63241,Q7Z2Z2,P49411 6 +Guanine-nucleotide releasing factor 0.4793070651234848 0.6843763400614463 0.4937375523745695 1.0 0.7742570571482703 9 Q02818,Q12802 2 +Thiol protease inhibitor 0.5597057419469951 0.5674148197539435 0.5704323835831033 1.0 0.8155301499150809 3 P20810 1 +DNA-directed DNA polymerase 0.5328878117470672 0.4786019634771599 0.6322218212503365 1.0 0.8281215405110042 3 Q9NRG0 1 +Methyltransferase 0.3407585775197043 0.3028474120121217 0.7620061494567176 1.0 0.9216172372179364 29 Q03164,Q9H7B4,Q9BV86,Q99873 4 +Dioxygenase 0.336957173891974 0.2071181189325333 0.8359176120358818 1.0 0.9597572582634198 15 P13674,Q9Y2K7,Q7LBC6,O60568,O15460 5 +Initiation factor 0.315706442687173 0.1779500896132895 0.8587621727405201 1.0 0.9726314066212848 35 Q04637,P78344,Q7Z478,Q9Y262,O75822,Q15056,P46199,Q9ULC4,Q14232,P55010,O15372,O75821,P20042,Q9NR50 14 diff --git a/protein_atlas_molecular_function/selections.json b/protein_atlas_molecular_function/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..2f203458d2d0e8a0591dc44ac1916096debcc2cb --- /dev/null +++ b/protein_atlas_molecular_function/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin capping", "Actin-binding", "Activator", "Acyltransferase", "Allosteric enzyme", "Aminoacyl-tRNA synthetase", "Aminopeptidase", "Aminotransferase", "Antibiotic", "Antimicrobial", "Antioxidant", "Aspartyl protease", "Blood group antigen", "Calcium channel", "Calmodulin-binding", "Carboxypeptidase", "Chaperone", "Chloride channel", "Chromatin regulator", "Cytokine", "DNA-binding", "DNA-directed DNA polymerase", "Decarboxylase", "Developmental protein", "Dioxygenase", "Dipeptidase", "Elongation factor", "Endonuclease", "Excision nuclease", "Exonuclease", "Fungicide", "GTPase activation", "Glycosidase", "Glycosyltransferase", "Growth factor", "Guanine-nucleotide releasing factor", "Helicase", "Heparin-binding", "Hormone", "Host cell receptor for virus entry", "Hydrolase", "Initiation factor", "Integrin", "Ion channel", "Isomerase", "Kinase", "Ligase", "Lyase", "Metalloenzyme inhibitor", "Metalloprotease", "Methyltransferase", "Mitogen", "Monooxygenase", "Motor protein", "Multifunctional enzyme", "Muscle protein", "Myosin", "Nuclease", "Nucleotidyltransferase", "Oxidoreductase", "Peroxidase", "Phospholipase A2 inhibitor", "Porin", "Prenyltransferase", "Protease", "Protease inhibitor", "Protein phosphatase", "Protein phosphatase inhibitor", "Protein synthesis inhibitor", "RNA-binding", "Receptor", "Repressor", "Ribonucleoprotein", "Ribosomal protein", "Rotamase", "Serine esterase", "Serine protease", "Serine protease inhibitor", "Serine/threonine-protein kinase", "Signal transduction inhibitor", "Thiol protease", "Thiol protease inhibitor", "Threonine protease", "Topoisomerase", "Transducer", "Transferase", "Translational shunt", "Translocase", "Tumor antigen", "Tyrosine-protein kinase", "Voltage-gated channel", "rRNA-binding", "tRNA-binding"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCC4", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR2", "ACTR3", "ADAM17", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "ANKHD1", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA2", "APEH", "APEX1", "APLP2", "APP", "APRT", "ARFGAP1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARMT1", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATG4B", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5B", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "B4GAT1", "BABAM1", "BABAM2", "BAG6", "BANF1", "BAZ1B", "BAZ2A", "BCAT2", "BCLAF1", "BIRC6", "BLM", "BLMH", "BLVRA", "BPTF", "BRCA1", "BRD2", "BRMS1L", "BSG", "BTF3", "BUB1B", "BUD23", "BZW1", "C12orf43", "CAD", "CALD1", "CALR", "CAMK2D", "CAMK2G", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBR1", "CBX3", "CCAR1", "CCAR2", "CCDC47", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC34", "CDC37", "CDC42", "CDC5L", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CEBPZ", "CECR2", "CELF1", "CENPB", "CERS2", "CFL1", "CFL2", "CHCHD3", "CHD4", "CHKA", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIRBP", "CKB", "CKMT1A*", "CLGN", "CLIC1", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT3", "CNOT6", "CNOT7", "CNOT9", "CNP", "COLGALT1", "COMT", "COPA", "COPS5", "CORO1B", "CORO1C", "COTL1", "COX2", "COX4I1", "CPD", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRYZ", "CS", "CSDE1", "CSK", "CSNK1A1", "CSRP2", "CSTB", "CSTF2", "CTBP1", "CTBP2", "CTDSPL2", "CTNNB1", "CTPS1", "CTPS2", "CTSA", "CUL5", "CXorf57", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF13", "DCAF7", "DCD", "DCPS", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DGCR8", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIAPH1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DPF2", "DPH2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DRG1", "DRG2", "DST", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "ECE1", "ECH1", "ECHS1", "ECI2", "EDC3", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EFL1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "EMD", "EMG1", "ENAH", "ENO1", "ENSA", "ENY2", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERCC2", "ERCC3", "ERCC6L", "ERO1A", "ERP44", "ESD", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOSC1", "EXOSC10", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "F11R", "FADS2", "FAH", "FAHD1", "FAM120B", "FAM208A", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FECH", "FEN1", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FOXK1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCN1", "GDI1", "GDI2", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GLA", "GLB1", "GLDC", "GLO1", "GLS", "GLUD1", "GLYR1", "GM2A", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNPAT", "GNPDA1", "GNS", "GOT1", "GOT2", "GPD2", "GPI", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HELLS", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIC2", "HIF1AN", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HLTF", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HOXA10", "HP1BP3", "HPRT1", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HTRA2", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDI1", "IFIT5", "IGBP1", "IGF2BP1", "IGF2BP3", "IGF2R", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMPDH2", "INA", "INF2", "INTS11", "IQGAP1", "IRS4", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "KARS", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0391", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC2", "KLC4", "KMT2A", "KRR1", "KYAT3", "L2HGDH", "LAMP1", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LDAH", "LDHA", "LDHB", "LEMD3", "LGMN", "LIG3", "LIMA1", "LIPA", "LNPEP", "LONP1", "LPCAT1", "LRPAP1", "LRPPRC", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LUC7L3", "LYAR", "LYPLA1", "MACF1", "MAGED2", "MAP1S", "MAP2K1", "MARC1", "MARCKS", "MARCKSL1", "MARK2", "MARS", "MAT2A", "MATR3", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED16", "METAP2", "METTL13", "MFN1", "MFN2", "MGEA5", "MGST2", "MGST3", "MID1", "MIF", "MINDY3", "MINPP1", "MKI67", "MMAB", "MMS19", "MOGS", "MORF4L1", "MOV10", "MPHOSPH10", "MPI", "MPRIP", "MPST", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSI2", "MTA1", "MTA2", "MTAP", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTR", "MYBBP1A", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAA15", "NAA40", "NAA50", "NADK2", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L4", "NARS", "NAT10", "NAXE", "NCL", "NCOA5", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFAF7", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEK9", "NELFCD", "NES", "NEU1", "NHP2", "NIFK", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOL11", "NOL6", "NOL8", "NOL9", "NONO", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDCD1", "NUDT1", "NUDT12", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUP153", "NUP98", "NUSAP1", "NXF1", "OAT", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OTUB1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCMT1", "PCNA", "PCYOX1", "PDCD4", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM7", "PEBP1", "PECR", "PELP1", "PEPD", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB2", "PHC2", "PHF5A", "PHF6", "PHGDH", "PI4KB", "PIN4", "PIR", "PISD", "PITHD1", "PITRM1", "PKM", "PKN2", "PLAA", "PLBD2", "PLD3", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PMPCB", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLD1", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR2B", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1R10", "PPP5C", "PPT1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF31", "PRPF4B", "PRPF8", "PSAT1", "PSIP1", "PSMB5", "PSMB6", "PSMB7", "PSMD10", "PSMD14", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTRH2", "PTRHD1", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB18", "RAB1A", "RAB1B", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RABGAP1", "RABGGTA", "RAC1", "RACK1", "RAD21", "RAD50", "RAD51AP1", "RALA", "RALY", "RANBP1", "RANBP2", "RANGAP1", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM34", "RBM39", "RBM4", "RBM45", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "RECQL5", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC3", "RHOA", "RHOT1", "RHOT2", "RIOK2", "RIPK1", "RNASEH2A", "RNASET2", "RNF114", "RNF20", "RNF40", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPP30", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRM1", "RRM2", "RRP1B", "RRP7A", "RRP8", "RRP9", "RSF1", "RTCB", "RTRAF", "RUVBL1", "RUVBL2", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAP18", "SAP30BP", "SARNP", "SARS", "SARS2", "SART3", "SCAF1", "SCAF8", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCO1", "SCP2", "SCPEP1", "SCRIB", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC61A1", 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0000000000000000000000000000000000000000..8fa47e9790d202ae5e44e2390dc2260121a636b3 --- /dev/null +++ b/protein_atlas_protein_class/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:bc713dc37e9f63ee2f0c49d25abc2c719238e494bf7fc8943ce9c092daf4f7e1 +size 61222 diff --git a/protein_atlas_protein_class/df_merge.tsv b/protein_atlas_protein_class/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..20f9dc09710ea20d2e29dfe1d6b432bfb57b9bbb --- /dev/null +++ b/protein_atlas_protein_class/df_merge.tsv @@ -0,0 +1,6 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 +Predicted membrane proteins 83 396 4.995009932979214 5.883273924562507e-07 204.61650485436897 563.8058252427185 3.080866334016093 0.3028099075873978 81.17076282318972 73.52280648113661 4.068861305085399 0.4187410497068249 9.852423487785978e-06 1.843089555741012e-07 6.991503900675188e-07 0.0029963732733708 +Predicted secreted proteins 11 37 3.3557918059199445 0.0007913811963875 15.29368932038835 51.737864077669904 1.393291060716792 0.256881456821794 5.463351773637434 6.9884942404294375 1.5049506819867255 0.3173597508227758 5.596969801370026e-07 6.219809984111455e-05 0.0062666107198901 0.0677777370039816 +Potential drug targets 34 389 2.587079789124495 0.0096793175762233 97.55339805825244 482.2839805825243 0.1164506319746192 0.6956405557980175 32.086496616991845 44.65677560523076 1.054724020710321 0.3686644405287784 2.6155504011865505e-06 5.409711248566783e-07 0.0001217622030522 0.0052684968305525 +CD markers 9 11 2.377354000378467 0.0174373444382762 6.548543689320389 16.62378640776699 0.159361413045758 0.3347758559744795 3.625700175504636 4.1209525283344535 1.5119526885132668 0.3016304730463651 0.0154102901166228 0.0208434347218513 0.0011950882606879 0.0359730013616337 +Transporters 52 294 2.3528261841964344 0.0186313408940399 108.9004854368932 367.3009708737864 1.469396346451591 0.4764419032567517 40.40141182476491 35.10022679965902 2.352674986871393 0.4490473364946538 0.0004208511408673 8.085957815911396e-05 0.0001471594697896 3.24043071503902e-07 diff --git a/protein_atlas_protein_class/metrics.json b/protein_atlas_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..8e00fc88ad7295e23dc6aff518504d48bf86f3fb --- /dev/null +++ b/protein_atlas_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2453, + "annotations_size": 20, + "title": "Average number of proteins per term", + "value": 406.75 +} \ No newline at end of file diff --git a/protein_atlas_protein_class/paths.json b/protein_atlas_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..20cb6ad476fe1e0ee782888f0f9307e0ec68056f --- /dev/null +++ b/protein_atlas_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_protein_class/fragment/C334/C334_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_protein_class/result.tsv b/protein_atlas_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..f5f63238229b15688ff13cff530327753e82542c --- /dev/null +++ b/protein_atlas_protein_class/result.tsv @@ -0,0 +1,13 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Predicted membrane proteins 0.5153336432002866 4.995009932979214 5.883273924562507e-07 1.1766482084844225e-05 1.1766547849145014e-05 396 Q6UXD5,P05067,Q9UIQ6,P11117,Q9C0H2,Q8IV08,P02786,P42892,O75976,Q8IXU6,O60830,Q5J8M3,P11717,Q14108,Q06481,P11279,Q8WTV0,Q15904,Q8NC54,O94813,Q99523,O00461,O15118,Q567V2,Q15375,P51790,Q92542,Q92896,Q9H2J7,O43657,Q5BJF2,O43772,Q9UBM7,Q99595,P10321,Q14126,Q14849,Q9Y624,Q15392,Q9HD45,O15269,Q14739,Q5W0Z9,Q9BQE5,P08195,Q8N4V1,O43464,O95831,P35613,Q8NCH0,Q8TCG1,Q10472,Q5VW38,O15127,Q8IXB1,Q92692,O43760,Q13423,Q8IY95,Q9Y282,Q93050,Q658P3,Q96G23,Q9Y487,Q8IWA4,Q6ZRP7,P05556,P30519,P55011,Q9HD20,Q86Y82,P51809,P01889,O14925,Q03519,Q5SNT2,Q12907,Q9UG56,Q92804,Q8IYS2,P08183,O43808,Q7Z6Z7 83 +Predicted secreted proteins 0.7829810628101777 3.3557918059199445 0.0007913811963875 0.0157091930522445 0.0052758746425836 37 O60888,P05067,Q9HB40,O00584,Q08380,Q02818,Q8WUJ1,O94813,P61916,P02786,Q9BTY2 11 +Potential drug targets 0.3838863552411818 2.587079789124495 0.0096793175762233 0.1767779699100186 0.0483965878811165 389 O00584,P06280,P11117,Q8IV08,P61916,P42892,P50897,Q14108,P16278,P15586,P06865,Q99519,Q15904,P07686,P10619,Q99523,O14773,O15118,P54802,P38571,Q13510,O43772,Q9UBM7,Q15392,P04062,P08236,Q9H2D1,O15269,Q14739,Q07021,Q9NWM8,O43464,Q96C86,Q8NCH0 34 +CD markers 0.8545786557299835 2.377354000378467 0.0174373444382762 0.2965956074056741 0.0532324025543998 11 P11279,Q92692,P08195,P02786,Q9Y624,P08183,P11717,P35613,P05556 9 +Transporters 0.4472869090766883 2.3528261841964344 0.0186313408940399 0.3134950301396615 0.0532324025543998 294 P05067,Q5VW38,Q9C0E2,Q9BSK2,O15127,Q9C0H2,P61916,P02786,Q8IY95,O15439,Q8IXU6,Q9Y6C9,Q93050,Q5J8M3,P11717,Q14108,O95373,Q8TB61,Q658P3,Q8TEX9,P61421,P11279,Q8WTV0,Q15904,O14828,P05026,Q99523,Q9NPA8,O15118,P54709,P24390,Q8IWA4,Q9H2J7,Q5BJF2,P05556,P55011,O43772,Q9HD20,Q14849,Q9BRK5,Q9UI26,Q03519,Q9H2D1,Q5SRE5,Q5W0Z9,O75436,Q07021,P08195,Q8N4V1,P08183,O43808,P35613 52 +Candidate cardiovascular disease genes 0.6718191789808142 1.169468997972589 0.24221472482373 0.9961012692675788 0.5382549440527334 7 P06865 1 +Enzymes 0.2930790343003069 0.96956645826047 0.3322626387457581 0.999689462872558 0.5719386573155005 740 Q9HB40,O00584,Q9UIQ6,P06280,P11117,Q8IV08,Q99538,P02786,Q9BTY2,P10253,P42892,P50897,O75976,Q9H3G5,P16278,P15586,P06865,Q99519,P07686,P10619,O14773,Q8NB78,Q92820,Q15375,P54802,P38571,Q9BV86,Q13510,P35790,P49721,Q9UBM7,O00148,Q15392,P04062,Q86UY6,P08236,P28072,O15269,Q14739,Q5W0Z9,P11233,P49427,Q9NWM8,P42785,Q9H7B4,Q9UHY1,O43464,Q12899,Q96C86,Q8NCH0,Q99873,Q13126,Q10472,Q9Y2K7,Q8TBC4,Q13423,P54132,Q14527,P55786,Q15185,P60900,Q96G23,Q9H4L7,Q10471,Q6ZRP7,Q16763,P23919,P30519,Q9NRN7,Q9ULM6,Q9H0R6,Q9UHG3,O43847,O95881,Q03164,Q9NRF8,P38398,Q9UG56,Q8N1G2,Q9Y680,Q92696,P17858,P08183,O60701,Q7Z6Z7,Q9BQC3,Q15165 87 +FDA approved drug targets 0.3718634578843461 0.9479337257383552 0.3431631943893003 0.9997765658219772 0.5719386573155005 93 P55011,P05067,Q13547,P49721,Q9Y2I1,P49069,Q02880,P02786,P42345,Q13423,P10253,P20020,P05556,P49356 14 +Human disease related genes 0.2887921275990939 0.8548862034871354 0.3926141491316872 0.9999533025231924 0.6040217678949035 737 P05067,O00584,O75503,P06280,P11117,Q8IV08,P61916,P10253,P17900,P42892,P50897,O43505,Q14108,P16278,P15586,P06865,Q99519,P07686,P10619,O14773,O15118,P54802,Q92542,P38571,Q13510,Q13501,O43772,Q9UBM7,P10321,Q14126,Q15392,P04062,P08236,O15269,Q14739,Q9BQE5,Q07021,Q15056,Q96EK5,Q9NWM8,Q01105,O43464,Q96C86,O95831 44 +Disease related genes 0.2887073204517738 0.5375466339472056 0.5908900815348486 0.99999998274956 0.7386126019185607 817 P05067,Q13126,O00584,Q9UHX1,O75503,P06280,P11117,Q8IV08,P61916,P02786,P10253,P17900,P42892,P50897,Q13423,Q8NC96,O43505,P54132,Q14108,Q9Y263,P16278,P15586,Q658P3,P06865,Q99519,Q5MNZ6,Q15904,P07686,P10619,Q99523,Q9Y487,O14773,O15118,Q9H4L7,Q9BUF5,Q10471,P54802,Q92542,P38571,O00170,O14979,Q13510,Q13501,Q96AX1,O43772,Q9UBM7,Q9H0R6,P10321,Q14126,P01889,O15143,Q15392,P04062,Q03164,Q03519,Q7Z2Z2,P08236,Q9ULM3,Q9H2D1,Q5SRE5,O15269,Q14739,P38398,Q9P032,Q9BZH6,Q07021,Q15056,P67870,Q96EK5,Q9NWM8,Q01105,O43464,Q96C86,O95831,Q8NCH0 75 +RAS pathway related proteins 0.3281868080159394 0.1856291066085448 0.8527356264863264 1.0 1.0 16 P61020,Q13177,P11233,O96013,P31751 5 +Metabolic proteins 0.2690783604930385 0.1056967761977119 0.915822938245714 1.0 1.0 700 P06280,P11117,Q8IV08,Q99538,P02786,Q9BTY2,P10253,P17900,P50897,O43505,P16278,P15586,P06865,Q99519,Q8WTV0,Q15904,P07686,P10619,O14773,O15118,Q92820,Q15375,P54802,Q9H2J7,P38571,Q13510,P35790,O43772,Q9UBM7,Q14849,Q15392,P04062,Q86UY6,P08236,Q9H2D1,O15269,Q14739,Q5W0Z9,P08195,P67870,P49427,Q9NWM8,Q9H7B4,Q8NCH0,Q99873,Q13126,Q10472,Q8TBC4,Q13423,Q14527,Q93050,P55786,Q15185,P83916,Q8NCN5,Q96G23,Q9Y487,Q10471,Q16763,P23919,P30519,P55011,Q9NRN7,Q9UHG3,Q03164,Q7Z2Z2,Q5SRE5,Q9NRF8,Q9UG56,Q8N1G2,Q9Y680,Q9NXR7,P17858,P08183,O60701,O43808,Q7Z6Z7,Q15165 78 diff --git a/protein_atlas_protein_class/selections.json b/protein_atlas_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..744ecd753314d41f3ff4ae68d93acead9d7c19ac --- /dev/null +++ b/protein_atlas_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Blood group antigen proteins", "CD markers", "Cancer-related genes", "Candidate cardiovascular disease genes", "Citric acid cycle related proteins", "Disease related genes", "Enzymes", "FDA approved drug targets", "Human disease related genes", "Metabolic proteins", "Plasma proteins", "Potential drug targets", "Predicted intracellular proteins", "Predicted membrane proteins", "Predicted secreted proteins", "RAS pathway related proteins", "RNA polymerase related proteins", "Ribosomal proteins", "Transcription factors", "Transporters"], "available_proteins": ["AAAS", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABHD10", "ABHD12", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR6", "ADAM17", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "AMOT", "ANAPC1", "ANAPC16", "ANAPC5", "ANAPC7", "ANK3", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOL2", "APOO", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG4B", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "B4GAT1", "BABAM1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCL2L12", "BCLAF1", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPTF", "BRCA1", "BRD2", "BRI3BP", "BRIX1", "BRMS1L", "BROX", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BYSL", "BZW1", "C12orf43", "C12orf73", "C15orf39", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C5orf15", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC47", "CCDC6", "CCDC86", "CCDC97", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD3EAP", "CDC123", "CDC23", "CDC27", "CDC34", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKAL1", "CEBPZ", "CECR2", "CELF1", "CENPB", "CENPI", "CEP170", "CERS2", "CFAP20", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD4", "CHERP", "CHID1", "CHKA", "CHMP3", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT10", "CNOT3", "CNOT6", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG7", "COIL", "COLGALT1", "COMMD2", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "CORO1B", "CORO1C", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DGCR8", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPF2", "DPH2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "ENSA", "ENY2", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERH", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120B", "FAM162A", "FAM208A", "FAM49B", "FAM8A1", "FAM98A", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FOXK1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GIGYF2", "GINS1", "GINS4", "GLA", "GLB1", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLGB1", "GOLIM4", "GORASP2", "GOT1", "GOT2", "GPAA1", "GPD2", "GPI", "GPR107", "GPR108", "GPRASP2", "GPS1", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAUS5", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIC2", "HIF1AN", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOXA10", "HP1BP3", "HPF1", "HPRT1", "HPS6", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMPDH2", "INA", "INCENP", "INF2", "INTS11", "INTS14", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRGQ", "IRS4", "ISOC1", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JPT2", "JUP", "KARS", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIAA2013", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC2", "KLC4", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMP1", "LAMTOR1", "LAMTOR2", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDAH", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3BP", "LGMN", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L3", "LYAR", "LYPLA1", "MACF1", "MAGED2", "MAGT1", "MAK16", "MAP1B", "MAP1S", "MAP2K1", "MAP4", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARCKSL1", "MARK2", "MARS", "MAT2A", "MATR3", "MAU2", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED16", "METAP2", "METTL13", "MFN1", "MFN2", "MGEA5", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MINPP1", "MKI67", "MLEC", "MMAB", "MMGT1", "MMS19", "MOB4", "MOGS", "MORF4L1", "MOV10", "MPHOSPH10", "MPI", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MYBBP1A", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFAF7", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFCD", "NEMF", "NENF", "NES", "NEU1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NPTN", "NRBP1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT12", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "OAT", "OCIAD1", "OCLN", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL11", "OSBPL6", "OSBPL9", "OTUB1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIGS", "PIGT", "PIN4", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLAA", "PLBD2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1R10", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PPP6R3", "PPT1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTRH2", "PTRHD1", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RABGGTA", "RABL6", "RAC1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAD51AP1", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM34", "RBM39", "RBM4", "RBM45", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "RECQL5", "REEP5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIF1", "RINT1", "RIOK2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF114", "RNF20", "RNF40", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA3", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF8", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", 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--- /dev/null +++ b/protein_atlas_subcellular_location_all/df_merge.tsv @@ -0,0 +1,4 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500 +Golgi apparatus 45 121 3.8902261038561146 0.0001001508614673 46.45873786407767 176.03155339805826 1.3643789213018729 0.3972771337532677 14.511319530749702 26.453870355965975 1.6568954592349954 0.4161874156663988 0.0042316092974786 0.011814196825615 0.0028308501651617 0.003204405085798 +Lysosomes 3 11 2.4767074033981022 0.0132600557936148 3.070388349514563 12.849514563106796 0.5262633691996788 0.494935559010686 2.4420262247147067 1.0913048915370858 0.8749364663493571 0.309114949195179 0.0038211367015083 0.0007914120786236 0.0010078083449561 0.012134686324044 +Endosomes 2 9 2.185511011070129 0.0288513994959664 4.225728155339806 11.570388349514564 -0.0613604201834061 0.6192296032571083 2.891235198776497 1.1833787585037423 0.7895406819612503 0.3021463247611612 0.0802348466038066 0.0117676307173903 0.0075942890928168 0.0472723399635447 diff --git a/protein_atlas_subcellular_location_all/metrics.json b/protein_atlas_subcellular_location_all/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..c4dae5ead7a8909476549dd5105e1117a252db17 --- /dev/null +++ b/protein_atlas_subcellular_location_all/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2453, + "annotations_size": 33, + "title": "Average number of proteins per term", + "value": 116.03030303030303 +} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/paths.json b/protein_atlas_subcellular_location_all/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..47bde05905e1fadc1b07f3aea3416c4387d01be3 --- /dev/null +++ b/protein_atlas_subcellular_location_all/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_subcellular_location_all/fragment/C334/C334_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/result.tsv b/protein_atlas_subcellular_location_all/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..48ebec6b733110aa70e9b2dcf6df781a9e8574aa --- /dev/null +++ b/protein_atlas_subcellular_location_all/result.tsv @@ -0,0 +1,12 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Golgi apparatus 0.6121304554952695 3.8902261038561146 0.0001001508614673 0.0032996879620493 0.0033049784284211 121 P05067,Q9HB40,Q5VW38,Q9H3P7,O15127,O43760,P40616,P50897,O15439,Q8IXU6,Q13610,Q93050,P11717,P16278,Q5MNZ6,O15258,O75955,Q8NC54,P04439,Q9UID3,Q99523,O00461,Q10471,P24390,Q6ZRP7,Q92896,Q6IAA8,Q02818,Q96A49,Q86Y82,P80303,Q6P179,Q9BRK5,Q6NUQ1,Q9HD45,Q9UG56,O95456,Q9Y678,Q9NWM8,Q93034,Q8IYS2,P35606,Q9UH62,Q8NCH0,Q9H8Y8 45 +Lysosomes 0.879103061466179 2.4767074033981022 0.0132600557936148 0.3562912619765875 0.0875163682378582 11 O75436,Q8WTV0,P02786 3 +Endosomes 0.8334012233908275 2.1855110110701292 0.0288513994959664 0.6194359804075433 0.1586826972278157 9 O75436,P02786 2 +Focal adhesion sites 0.5836323859352526 1.7297129018665756 0.0836815824259686 0.9440845633883508 0.262164416502013 23 O60888,P11233,Q9UHB6,Q9Y487,Q96HC4,P08183,P05556 7 +Microtubules 0.520463553628128 1.684499338395425 0.092085207214263 0.9587439122734184 0.262164416502013 38 P55209,Q02818,Q9BZH6,P61163,Q9BUF5,O43663,Q9Y624,Q9HC35,O60830 9 +Vesicles 0.4259599584348522 1.6032891643290963 0.1088708276537224 0.9777135026890612 0.262164416502013 216 P05067,O15127,Q92791,Q9NUD5,Q99538,O75153,P10253,P17900,Q8NC96,P50897,P31751,Q93050,P11717,Q8TB61,Q06481,P16278,P06865,Q99519,P36915,Q8WTV0,O14828,Q7Z392,Q9UID3,P10619,Q9Y487,O15118,P24390,P51790,Q6IAA8,Q9H2J7,P38571,Q9NWV4,P30519,Q13501,P55011,Q9Y4C2,Q9HD20,Q86Y82,Q9H0R6,Q7Z3T8,Q9NRY5,P49069,P51809,Q14849,O15143,Q9HD45,P08236,Q5W0Z9,Q8N1G2,P42785,Q9BX40,P35613,O15460 53 +Cell Junctions 0.4982058168941837 1.4895697273899746 0.1363374067322471 0.9920684945226238 0.2999422948109437 37 Q9Y4C2,Q99519,Q9UDY2,Q14126,Q92692,Q9NV06,Q9Y624,Q9BW91,Q66K74,O43657 10 +Endoplasmic reticulum 0.3387170292961221 0.4962258275976206 0.6197350906678682 0.999999999999986 0.8768674911004339 168 Q92791,Q8IV08,P13674,P30533,Q9H3G5,Q13162,O14967,Q8WUJ1,Q96G23,Q9NVZ3,P27635,Q8TED0,Q70UQ0,Q13217,Q5BJF2,P05556,O43852,O43169,P35790,P08708,Q9UBM7,P51571,Q96CN7,Q14849,Q9UM00,Q03519,Q15631,P20810,Q14257,O15269,Q9Y3U8,Q9Y680,P35606,P50402,O15460,Q96CS3 36 +Mitotic spindle 0.3785029643179536 0.3917904420367533 0.6952130577914442 1.0 0.8768674911004339 16 Q8WVJ2,Q14203,Q15477,Q9BUF5,P07437,P68371,Q02241,Q9NWV4 8 +Lipid droplets 0.3365432372238577 0.0900056217240085 0.9282827474734788 1.0 1.0 7 Q01105 1 +Midbody ring 0.2200898325847318 0.0142088545612009 0.988663355782316 1.0 1.0 4 Q02241,Q06203,Q96JM3 3 diff --git a/protein_atlas_subcellular_location_all/selections.json b/protein_atlas_subcellular_location_all/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..267ca1a22a01384848858fbfca65f81b2a044bbf --- /dev/null +++ b/protein_atlas_subcellular_location_all/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin filaments", "Cell Junctions", "Centriolar satellite", "Centrosome", "Cytokinetic bridge", "Cytoplasmic bodies", "Cytosol", "Endoplasmic reticulum", "Endosomes", "Focal adhesion sites", "Golgi apparatus", "Intermediate filaments", "Kinetochore", "Lipid droplets", "Lysosomes", "Microtubule ends", "Microtubules", "Midbody", "Midbody ring", "Mitochondria", "Mitotic chromosome", "Mitotic spindle", "Nuclear bodies", "Nuclear membrane", "Nuclear speckles", "Nucleoli", "Nucleoli fibrillar center", "Nucleoli rim", "Nucleoplasm", "Peroxisomes", "Plasma membrane", "Rods & Rings", "Vesicles"], "available_proteins": ["AAAS", "AARS", "AARS2", "AARSD1", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABHD10", "ABHD6", "ACAA2", "ACACA", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR6", "ADAM17", "ADAR", "ADD1", "ADD3", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "AMOT", "ANAPC1", "ANAPC16", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOO", "APP", "APRT", "ARCN1", "ARFGAP1", "ARG2", "ARHGDIA", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC3", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG4B", "ATIC", "ATL2", "ATP13A1", "ATP1B3", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6V0A1", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "BABAM1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCL2L12", "BCLAF1", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPTF", "BRCA1", "BRD2", "BRI3BP", "BRIX1", "BRMS1L", "BROX", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BYSL", "BZW1", "C12orf43", "C12orf73", "C15orf39", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C5orf15", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC47", "CCDC6", "CCDC86", "CCDC97", "CCT2", "CCT3", "CCT4", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD3EAP", "CDC123", "CDC27", "CDC34", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CEBPZ", "CECR2", "CELF1", "CENPB", "CENPI", "CEP170", "CERS2", "CFAP20", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD4", "CHID1", "CHKA", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLINT1", "CLNS1A", "CLPP", "CLPTM1", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT10", "CNOT3", "CNOT6", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG7", "COIL", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "CORO1B", "COTL1", "COX4I1", "COX5B", "COX6C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRKL", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF13", "DCAF7", "DCAKD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DGCR8", "DHCR7", "DHFR", "DHPS", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOHH", "DPF2", "DPH2", "DPP3", "DPP9", "DPYSL2", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "EBNA1BP2", "ECH1", "ECHS1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELP1", "ELP2", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "ENSA", "ENY2", "EPB41", "EPB41L2", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERH", "ERLIN2", "ERP29", "ESD", "ESF1", "ESYT1", "ESYT2", "ETFA", "ETFB", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC3", "EXOSC5", "EXOSC7", "EZR", "F11R", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120B", "FAM162A", "FAM208A", "FAM49B", "FAM8A1", "FAM98A", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FOXK1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALK1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GIGYF2", "GINS1", "GINS4", "GLB1", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GOLGA3", "GOLGB1", "GOLIM4", "GORASP2", "GOT1", "GPAA1", "GPD2", "GPI", "GPR107", "GPR108", "GPRASP2", "GPS1", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HERC2", "HEXA", "HIBCH", "HIC2", "HIF1AN", "HINT2", "HIST1H1C", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLCS", "HLTF", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOXA10", "HP1BP3", "HPF1", "HPRT1", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPH1", "HTRA2", "HTT", "HUWE1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IFIT5", "IGBP1", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMPDH2", "INA", "INCENP", "INF2", "INTS11", "INTS14", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRGQ", "ISOC1", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JPT2", "JUP", "KARS", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIAA2013", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KLC2", "KLC4", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMTOR1", "LAMTOR2", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LEMD3", "LETM1", "LGMN", "LIG3", "LIMA1", "LIPA", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM6", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L3", "LYAR", "LYPLA1", "MACF1", "MAGED2", "MAK16", "MAP1B", "MAP1S", "MAP2K1", "MAP4", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARCKSL1", "MARK2", "MARS", "MAT2A", "MATR3", "MAU2", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED16", "METAP2", "METTL13", "MFN1", "MFN2", "MGEA5", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MKI67", "MMAB", "MMS19", "MOGS", "MORF4L1", "MOV10", "MPHOSPH10", "MPI", "MPP2", "MPRIP", "MPST", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL21", "MRPL28", "MRPL37", "MRPL38", "MRPL39", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH2", "MTDH", "MTFP1", "MTHFD1L", "MTHFD2", "MTIF2", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MYBBP1A", "MYG1", "MYH10", "MYH14", "MYH9", "MYO1B", "MYO1C", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAGK", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFB11", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEFL", "NEFM", "NELFCD", "NEMF", "NES", "NEU1", "NHLRC2", "NIFK", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NPTN", "NRBP1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NT5DC1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP188", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUPL2", "NUSAP1", "NVL", "NXF1", "OAT", "OCIAD1", "OCLN", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL11", "OSBPL6", "OSBPL9", "OTUB1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCM1", "PCMT1", "PCNA", "PCNP", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PGAM1", "PGAM5", "PGD", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIN4", "PIR", "PISD", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLAA", "PLD3", "PLEC", "PLIN3", "PLOD1", "PLOD2", "PLRG1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPID", "PPIF", "PPIG", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1R10", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PPP6R3", "PPT1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PRIM2", "PRKACA", "PRKAR1A", "PRKCSH", "PRKDC", "PRMT1", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA4", "PSMA5", "PSMA6", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR2", "PTPA", "PTPN1", "PTRH2", "PTRHD1", "PUF60", "PUM3", "PUS1", "PUS7", "PWP1", "PWP2", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB13", "RAB14", "RAB1A", "RAB1B", "RAB24", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RABL6", "RAC1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAD51AP1", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM34", "RBM39", "RBM4", "RBM45", "RBM5", "RBM8A", "RBMX", "RCC1", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH13", "RDX", "RECQL", "RECQL5", "REEP5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT2", "RIF1", "RINT1", "RIOK2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNF114", "RNF20", "RNF40", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL32", "RPL34", "RPL35", "RPL36", "RPL36A", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF8", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC16A", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SIN3A", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35B2", "SLC35F2", "SLC3A2", "SLC6A15", "SLC9A3R1", "SLFN11", "SLIRP", "SLK", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD2", "SNRPD3", "SNW1", "SNX1", "SNX2", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPCS2", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SQLE", "SQSTM1", "SRCAP", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRPK1", "SRPK2", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "SSU72", "STAG2", "STARD3", "STAT3", "STAU1", "STAU2", "STEAP3", "STIP1", "STMN1", "STOML2", "STRAP", "STRN4", "STT3B", "STUB1", "STX12", "STX18", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TACO1", "TAF15", "TAGLN2", "TALDO1", "TAMM41", "TAP1", "TAP2", "TARDBP", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TDP2", "TDRKH", "TECR", "TELO2", "TEX10", "TFAM", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMMDC1", "TIPRL", "TJP1", "TJP2", "TKT", "TLN1", "TM9SF3", "TMCO1", "TMED10", "TMEM109", "TMEM126A", "TMEM126B", "TMEM192", "TMEM201", "TMEM205", "TMEM214", "TMEM230", "TMEM97", "TMOD3", "TMX1", "TMX2", "TMX4", "TNKS1BP1", "TNPO1", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOX4", "TP53", "TP53BP1", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAP1", "TRAPPC11", "TRAPPC5", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRMT6", "TRMU", "TRNT1", "TROVE2", "TSC2", "TSFM", "TSG101", "TSN", "TSPAN6", "TSR1", "TSTA3", "TTC1", "TTC19", "TTC21B", "TTC37", "TTC38", "TTC4", "TTK", "TTLL12", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UCHL5", "UFC1", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC45A", "UNG", "UPF1", "UPF3B", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USMG5", "USO1", "USP10", "USP14", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VBP1", "VCL", "VCP", "VDAC2", "VDAC3", "VIM", "VIRMA", "VPS26A", "VPS29", "VPS33A", "VPS35", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WBP11", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR45B", "WDR46", "WDR5", "WDR6", "WDR61", "WDR77", "WDR82", "WIZ", "WRAP53", "XAB2", "XPNPEP1", "XPO1", "XPO4", "XPO5", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YEATS2", "YEATS4", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAQ", "ZADH2", "ZBTB10", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZDHHC20", "ZFR", "ZFYVE16", "ZMYM2", "ZMYM4", "ZNF148", "ZNF281", "ZNF318", "ZNF326", "ZNF638", "ZNF687", "ZRANB2", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ABCC4", "ACBD3", "ACTR1A", "AKT2", "APLP2", "APP", "ARL1", "ARMCX3", "ARPC1B", "ATP13A1", "ATP6V0A1", "ATP6V0A2", "BSG", "C1orf123", "C5orf15", "CALU", "CAMLG", "CAST", "CERS2", "CHAMP1", "CHKA", "CHST14", "CLCN3", "CLGN", "CLUH", "CMTR1", "COPB2", "COPG1", "CPVL", "CTSA", "CUL5", "CUTA", "CYB5B", "CYB5D2", "DCAF13", "DCTN1", "DHCR7", "DNAJC3", "DSG2", "EMD", "EML4", "ERAP2", "F11R", "FAF2", "FAM114A2", "FKBP14", "FKBP7", "FLOT1", "GAA", "GALNT2", "GLB1", "GLG1", "GM2A", "GNL1", "GOLIM4", "GORASP2", "GPR107", "GUSB", "HEXA", "HLA-A", "HMOX2", "IGF2R", "IKBIP", "ISOC1", "ITGB1", "KDELR1", "KIAA2013", "KIF23", "LAMTOR1", "LGMN", "LIMA1", "LIPA", "LRPAP1", "LSM14B", "MAP1S", "NAP1L1", "NECAP1", "NECAP2", "NECTIN2", "NEU1", "NPC1", "NUCB1", "NUCB2", "NUDCD2", "NUDT9", "P3H4", "P4HA1", "P4HA2", "PDLIM5", "PISD", "PLD3", "PPAT", "PPT1", "PRC1", "PRCP", "PRDX4", "PSMG1", "PWP1", "QRSL1", "QSOX2", "RALA", "RCN2", "RER1", "RINT1", "RPL10", "RPL36", "RPS17", "SCAMP2", "SCAMP3", "SCARB1", "SCPEP1", "SDF4", "SET", "SKIV2L", "SLC12A2", "SLC35B2", "SLC35F2", "SLC6A15", "SORT1", "SPTLC1", "SQSTM1", "SSR4", "STARD3", "STX12", "SYAP1", "SYNGR2", "TAP2", "TCAF1", "TFRC", "TIMM17B", "TJP2", "TM9SF3", "TMCO1", "TMEM97", "TRAPPC11", "TSN", "TSPAN6", "TUBB", "TUBB4B", "TUBB6", "UTP15", "VAMP7", "VPS26A", "VPS51", "WDR11", "WDR45B", "ZCCHC3", "ZDHHC20", "ZFYVE16"]} \ No newline at end of file