diff --git a/interpro_active_site/advanced/idx2term.json b/interpro_active_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_active_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_active_site/basic/idx2term.json b/interpro_active_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_active_site/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_active_site/consensus.joblib b/interpro_active_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..f59c39bcf9c7d09bde7c99b219bc7bb3541b4e4a --- /dev/null +++ b/interpro_active_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:ceedf42b4582f2bf1180729e33a4fd0d62d351686878591077e8d08d248cc047 +size 62629 diff --git a/interpro_active_site/df_merge.tsv b/interpro_active_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_active_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_active_site/metrics.json b/interpro_active_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..ec87ed8fe7e0e7307241da31d389069704877091 --- /dev/null +++ b/interpro_active_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2454, + "annotations_size": 50, + "title": "Average number of proteins per term", + "value": 2.3 +} \ No newline at end of file diff --git a/interpro_active_site/paths.json b/interpro_active_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..ea07ff957bc44c4d55f7b51449be9ce1b31c68bb --- /dev/null +++ b/interpro_active_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C340/C340_val_log2fc"} \ No newline at end of file diff --git a/interpro_active_site/result.tsv b/interpro_active_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c9a862ad1fbb6797580a462e48a01ac10c604d4d --- /dev/null +++ b/interpro_active_site/result.tsv @@ -0,0 +1,7 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Serine carboxypeptidase, serine active site [IPR018202] 0.9673602611179124 1.831329934829985 0.0670513121898026 0.96889086682721 0.1457637221517448 3 Q9HB40,Q9H3G5 2 +Histidine acid phosphatase active site [IPR033379] 0.8054649265905265 1.4542303762481574 0.1458824459505403 0.9996233982058736 0.2515214585354144 2 P11117 1 +Ubiquitin-conjugating enzyme, active site [IPR023313] 0.6481375317504068 1.200462870417974 0.2299596244047284 0.999997883224216 0.3616772089779527 6 Q16763 1 +Cysteine peptidase, cysteine active site [IPR000169] 0.6193390452876388 0.5235844503798823 0.6005675990669668 1.0 0.6970860879653368 3 Q13867,P17655 2 +Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345] 0.4804241435562917 0.2323689299772647 0.8162514788022606 1.0 0.8355808896618625 2 Q9NQ88 1 +Tyrosine-protein kinase, active site [IPR008266] 0.457772337821298 0.1200696217327232 0.9044279966079762 1.0 0.9044279966079762 3 Q15375,P41240 2 diff --git a/interpro_active_site/selections.json b/interpro_active_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..52f1243137a2234deace0fea0f2584812013132c --- /dev/null +++ b/interpro_active_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenylosuccinate synthase, active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Cysteine peptidase, cysteine active site [IPR000169]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]", "Uracil-DNA glycosylase, active site [IPR018085]"], "available_proteins": ["ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADSS", "AKT2", "APEH", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "BLMH", "CAMK2D", "CAMK2G", "CAPN1", "CAPN2", "CDC34", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CTSA", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "EPHA7", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLUD1", "GSK3A", "GSK3B", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "LDHA", "LDHB", "LONP1", "MAP2K1", "MARK2", "MDH1", "MDH2", "MTMR6", "NEK9", "NME1", "PAK2", "PBK", "PGAM1", "PKM", "PKN2", "PLK1", "PREP", "PRKACA", "PRPF4B", "PTK7", "PTPN1", "RIPK1", "RNASET2", "ROCK2", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SRPK2", "SUCLG1", "TALDO1", "TIGAR", "TOP1", "TPI1", "TPP2", "TTK", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "UMPS", "UNG", "VRK1"], "leading_proteins": ["ACP2", "BLMH", "CAPN2", "CPVL", "CSK", "EPHA7", "SCPEP1", "TIGAR", "UBE2S"]} \ No newline at end of file diff --git a/interpro_binding_site/advanced/idx2term.json b/interpro_binding_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..1f2df466d020a9613ebb803cec2bf89e8e4d80ca --- /dev/null +++ b/interpro_binding_site/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "EF-Hand 1, calcium-binding site [IPR018247]"} \ No newline at end of file diff --git a/interpro_binding_site/advanced/plot_0.png b/interpro_binding_site/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..f449236e40103bff2615b26e4e29ee381928ccbf --- /dev/null +++ b/interpro_binding_site/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:e3be12578d7a6a81c0fdbcf1a1f98f0dfda4ef98698cc0107f8d6d31fc7a6759 +size 187232 diff --git a/interpro_binding_site/basic/idx2term.json b/interpro_binding_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..1f2df466d020a9613ebb803cec2bf89e8e4d80ca --- /dev/null +++ b/interpro_binding_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "EF-Hand 1, calcium-binding site [IPR018247]"} \ No newline at end of file diff --git a/interpro_binding_site/basic/plot_0.png b/interpro_binding_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..8b3fafbcc030c28ded0b8e791bd331c062239363 --- /dev/null +++ b/interpro_binding_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:79cd235d95cebbd243e09fd2bf176b0077081926a382eede9bac4bd256a8a767 +size 137897 diff --git a/interpro_binding_site/consensus.joblib b/interpro_binding_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..a75aec41a11110ee25e36023ac0eca72b3954537 --- /dev/null +++ b/interpro_binding_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:373b2ce354b18ccf05258ab2db5ac896d51d6e74cf90d7c8caf9230862b80aa2 +size 58703 diff --git a/interpro_binding_site/df_merge.tsv b/interpro_binding_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..cbd1fd810dbba77d79ddb1c3cd5db7def1c91502 --- /dev/null +++ b/interpro_binding_site/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +EF-Hand 1, calcium-binding site [IPR018247] 9 32 2.362191464775633 0.0181672567178221 10.019417475728156 36.70631067961165 0.9532938980945532 0.3894555773109194 3.76037227687173 3.057484685571999 1.1082350706804749 0.3408841825650379 1.0 0.0551599902794207 0.1786715045389017 0.0028924350901622 0.001316772075281 diff --git a/interpro_binding_site/metrics.json b/interpro_binding_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..7a70ec089363c213d20e15fa03d5636bd97f3a4a --- /dev/null +++ b/interpro_binding_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2454, + "annotations_size": 27, + "title": "Average number of proteins per term", + "value": 4.111111111111111 +} \ No newline at end of file diff --git a/interpro_binding_site/paths.json b/interpro_binding_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..f768eaeac25506e42545cf194c3d05dda104fe9d --- /dev/null +++ b/interpro_binding_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C340/C340_val_log2fc"} \ No newline at end of file diff --git a/interpro_binding_site/result.tsv b/interpro_binding_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..966f8d645be07159d55296ec67b75ef68bf8d265 --- /dev/null +++ b/interpro_binding_site/result.tsv @@ -0,0 +1,5 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +EF-Hand 1, calcium-binding site [IPR018247] 0.5710253232717362 2.362191464775633 0.0181672567178221 0.3904451283227663 0.0922401639565371 32 Q02818,Q9Y680,Q9BRK5,P80303,P30626,Q6NUK1,Q14257,Q9NWM8,O43852 9 +Beta tubulin, autoregulation binding site [IPR013838] 0.9726530612244896 2.317108644920705 0.0204978142125638 0.4283291394202846 0.0922401639565371 4 Q9BUF5,P07437,P68371 3 +Peptidase M16, zinc-binding site [IPR001431] 0.6775130296815998 1.238363984782448 0.2155811284974353 0.998578336214912 0.3499096454543592 5 O43847 1 +Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798] 0.5469004893964198 0.4199294669115569 0.6745369806684534 0.9999999999999312 0.7284999391219297 2 P34897 1 diff --git a/interpro_binding_site/selections.json b/interpro_binding_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..9710ba2af837d4ee7a3a503b10d3b6d60c1de7d7 --- /dev/null +++ b/interpro_binding_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Protein kinase, ATP binding site [IPR017441]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]", "Ureohydrolase, manganese-binding site [IPR020855]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT2", "APEX1", "ARG2", "CALU", "CAMK2D", "CAMK2G", "CAPN1", "CAPN2", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "COX2", "COX5B", "CSK", "CSNK1A1", "CYB5B", "DLAT", "DLST", "DST", "EHD1", "EIF2AK2", "EPHA7", "FKBP10", "FKBP14", "FKBP7", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "GSK3B", "HK1", "HK2", "IDE", "ILKAP", "IQGAP1", "LETM1", "MACF1", "MAP2K1", "MARK2", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH14", "MYH9", "MYO1B", "MYO1C", "NRDC", "NUCB1", "NUCB2", "PA2G4", "PAK2", "PAK4", "PC", "PCCA", "PDCD6", "PDHX", "PEF1", "PGD", "PKN2", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PPM1G", "PRKACA", "PRKCSH", "PSAT1", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK2", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SRI", "SRPK1", "SRPK2", "TKT", "TTK", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["CALU", "FKBP14", "FKBP7", "NRDC", "NUCB1", "NUCB2", "RCN2", "SDF4", "SHMT2", "SLC25A24", "SRI", "TUBB", "TUBB4B", "TUBB6"]} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/idx2term.json b/interpro_conserved_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..c2d87a456c859f7d763df70f2e8915263713ecf7 --- /dev/null +++ b/interpro_conserved_site/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Proteasome beta-type subunit, conserved site [IPR016050]"} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/plot_0.png b/interpro_conserved_site/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..c359f4a675bc37906b64fc1df161840f385a0c44 --- /dev/null +++ b/interpro_conserved_site/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:730776dec237959552ebd06506bee53cc1b007294263cb2a7db14e75529adbb9 +size 189488 diff --git a/interpro_conserved_site/basic/idx2term.json b/interpro_conserved_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..c2d87a456c859f7d763df70f2e8915263713ecf7 --- /dev/null +++ b/interpro_conserved_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Proteasome beta-type subunit, conserved site [IPR016050]"} \ No newline at end of file diff --git a/interpro_conserved_site/basic/plot_0.png b/interpro_conserved_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..621f46462ab5f9e15e5979e6e78eb826fd1899b6 --- /dev/null +++ b/interpro_conserved_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:405bf5d41679cc6424eadab19cc97dadc6f66609b8c0e99bf037819116401bf0 +size 143387 diff --git a/interpro_conserved_site/consensus.joblib b/interpro_conserved_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..eb17209878e370eb705b57ea7bb795a7d2ad259f --- /dev/null +++ b/interpro_conserved_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:230a6f1a8fb26c616ad857edcc33a24228e05efc5fc33b8afb68efa86eda438f +size 86123 diff --git a/interpro_conserved_site/df_merge.tsv b/interpro_conserved_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..65cbcebda46b0f8cff867fc654cbf675998fd3fc --- /dev/null +++ b/interpro_conserved_site/df_merge.tsv @@ -0,0 +1,3 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Proteasome beta-type subunit, conserved site [IPR016050] 5 8 2.4991354583278875 0.0124496713168613 3.7135922330097086 7.970873786407767 1.4913184573846054 0.1902243906475925 1.515457478026574 0.1681602725795027 1.0170822776023185 0.2455850375425174 1.0 0.0470522829573702 0.0039921150854813 6.194004931981708e-05 2.1281179634986496e-06 +Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818] 1 5 2.10981464482015 0.0348743245356633 1.8349514563106797 4.495145631067961 -0.0268416016144192 0.3268992301433215 1.18113888908689 0.4999764345469411 1.4254920509394828 0.309635855483207 1.0 0.0002241871259369 0.0009157120850054 0.0055254488719224 0.0209220238917207 diff --git a/interpro_conserved_site/metrics.json b/interpro_conserved_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..89c0135694a618e2dbcdcf86b3ca3a1b6e583883 --- /dev/null +++ b/interpro_conserved_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2454, + "annotations_size": 252, + "title": "Average number of proteins per term", + "value": 2.488095238095238 +} \ No newline at end of file diff --git a/interpro_conserved_site/paths.json b/interpro_conserved_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..c2f06e048b22c2042a95f44ec40ccc5a1b0ed85e --- /dev/null +++ b/interpro_conserved_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C340/C340_val_log2fc"} \ No newline at end of file diff --git a/interpro_conserved_site/result.tsv b/interpro_conserved_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..4e1179e6e9f46bb635bacc27a5d993fcb989081c --- /dev/null +++ b/interpro_conserved_site/result.tsv @@ -0,0 +1,28 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Proteasome beta-type subunit, conserved site [IPR016050] 0.8481977032997318 2.4991354583278875 0.0124496713168613 0.9574472192309592 0.0825609782065543 8 P28070,P28072,P20618,P49721,Q99436 5 +Tubulin, conserved site [IPR017975] 0.9726530612244896 2.317108644920705 0.0204978142125638 0.9945879327175782 0.1033089836313215 4 Q9BUF5,P07437,P68371 3 +Haem oxygenase conserved site [IPR018207] 0.991435562805872 2.2395010215982603 0.0251233349237796 0.9983582080193628 0.1090679488452607 2 P30519 1 +Sterol reductase, conserved site [IPR018083] 0.963295269168024 2.1231837101527073 0.0337384604655155 0.999824667364121 0.1371305167308051 2 Q14739 1 +Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818] 0.8873152080167173 2.10981464482015 0.0348743245356633 0.9998696427794048 0.1394972981426532 5 P48735 1 +3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180] 0.9396411092985296 2.0245803127813957 0.04291047749655 0.999984149403687 0.1501866712379252 2 Q16836 1 +Guanylate kinase, conserved site [IPR020590] 0.9102773246329496 1.901198589597285 0.0572760057708205 0.9999996493213344 0.178192017953664 2 Q14168 1 +Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364] 0.8036526172755745 1.6442491194120992 0.1001247545498675 0.999999999997156 0.2498162192729369 4 Q8N4Q0 1 +Profilin conserved site [IPR027310] 0.7993474714518656 1.4279710796467522 0.1533001828542315 1.0 0.3192698023079863 2 P07737 1 +Clathrin adaptor complex, small chain [IPR000804] 0.7944535073409462 1.4069631466221186 0.159438317092758 1.0 0.3274420832091019 2 P61923 1 +Chromo domain, conserved site [IPR023779] 0.8494492044063684 1.37645728993164 0.1686801015807824 1.0 0.3320889499871653 3 Q13185,P83916 2 +14-3-3 protein, conserved site [IPR023409] 0.6347601898743878 1.1426666095990483 0.2531770382339848 1.0 0.4245067897375093 6 P61981,P27348,Q04917 3 +Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326] 0.7096247960848292 1.0451239726075388 0.2959656757463005 1.0 0.4439485136194507 2 P24534 1 +Actin, conserved site [IPR004001] 0.745716029689144 0.9765435175338548 0.3287951935941045 1.0 0.4704558601695137 3 P61163 1 +Annexin repeat, conserved site [IPR018252] 0.5712647991307751 0.791453646671129 0.4286793152489159 1.0 0.553762970714589 5 P20073,P04083,P50995 3 +Thioredoxin, conserved site [IPR017937] 0.4461416946817904 0.6812651528898246 0.4957037287425352 1.0 0.6063948526364994 10 Q8IXB1,Q9H1E5,P07237 3 +Short-chain dehydrogenase/reductase, conserved site [IPR020904] 0.4479156976000573 0.6519683230489928 0.5144216075444854 1.0 0.6086114793484053 9 Q8NBN7,Q06136 2 +Aldehyde dehydrogenase, glutamic acid active site [IPR029510] 0.4745324682478 0.5984465917620672 0.5495419853778523 1.0 0.6294753650691762 7 O94788,P51648,P30837 3 +HMG box A DNA-binding domain, conserved site [IPR017967] 0.6028333047387474 0.4706184247695404 0.6379132478198473 1.0 0.7019831373388712 3 P26583 1 +Aldehyde dehydrogenase, cysteine active site [IPR016160] 0.4348979185660808 0.4337198266231595 0.6644919072830191 1.0 0.7280520027622644 7 O94788,P51648,P30837 3 +Dynamin, GTPase region, conserved site [IPR019762] 0.5097879282218654 0.3080940396808397 0.7580107764364625 1.0 0.809401337550799 2 O00429 1 +ABC transporter-like, conserved site [IPR017871] 0.3360751075974014 0.1711004517138927 0.8641447806939491 1.0 0.8998464371225551 9 P08183 1 +Syntaxin/epimorphin, conserved site [IPR006012] 0.4818441452468384 0.1612766362946302 0.8718755239001781 1.0 0.8998464371225551 3 Q86Y82,Q9P2W9 2 +Calreticulin/calnexin, conserved site [IPR018124] 0.4802121583027315 0.1582512317858274 0.8742588351992797 1.0 0.8998464371225551 3 O14967,P27797 2 +Adenylate kinase, conserved site [IPR033690] 0.4798041615667128 0.1575001334127116 0.8748507027580397 1.0 0.8998464371225551 3 P00568,P54819 2 +AT hook, DNA-binding motif [IPR017956] 0.4403586849274479 0.0948118560984412 0.9244642694932056 1.0 0.9393749835172897 3 P17096 1 +Ribosomal protein S2, conserved site [IPR018130] 0.3911092985318211 0.0800987456663184 0.9361587203572472 1.0 0.9474377410844428 2 P08865 1 diff --git a/interpro_conserved_site/selections.json b/interpro_conserved_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..905157c65da815ce21b24a0c7d31daea88c42c84 --- /dev/null +++ b/interpro_conserved_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Amyloidogenic glycoprotein, copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Bromodomain, conserved site [IPR018359]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific, conserved site [IPR031303]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "Homeobox, conserved site [IPR017970]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Lysophospholipase patatin, conserved site [IPR001423]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RIO kinase, conserved site [IPR018935]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P, conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class V, conserved site [IPR001426]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]"], "available_proteins": ["AAAS", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ACAA2", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP3M1", "AP3S1", "APEX1", "APLP2", "APP", "ARIH2", "ATAD1", "ATP5C1", "ATP5O", "BAG6", "BAZ1A", "BAZ1B", "BAZ2A", "BCAT2", "BLM", "BOP1", "BPTF", "BRCA1", "BRD2", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CBR1", "CBX1", "CBX3", "CBX5", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDKAL1", "CECR2", "CHAF1B", "CHD4", "CLGN", "CMPK1", "CNDP2", "COPA", "COPZ1", "CORO1B", "CORO1C", "CPOX", "CRYZ", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CYP51A1", "DCAF13", "DCAF7", "DCPS", "DCXR", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX6", "DHCR7", "DHFR", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX38", "DHX40", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DRG1", "DRG2", "DSG2", "DST", "DTYMK", "DYNLL1", "ECH1", "ECHS1", "ECI2", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "ENO1", "EPB41", "EPB41L2", "EPHA7", "EPRS", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXC1", "FOXK1", "FUCA2", "GAA", "GALK1", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GMPPA", "GNPDA1", "GNS", "GPI", "GRHPR", "GRWD1", "GSPT1", "GTF3C2", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HOXA10", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "ILVBL", "IMPDH2", "INA", "IQGAP1", "IVD", "KDM2A", "KDSR", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "LAMP1", "LARS", "LARS2", "LBR", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRWD1", "LSS", "MACF1", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "ME2", "MGST2", "MID1", "MIF", "MPI", "MPP2", "MPP6", "MPST", "MRPL24", "MRPL3", "MRPS11", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFV1", "NEFL", "NEFM", "NES", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD2", "NSF", "NUBP2", "NUDT1", "NUDT12", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL6", "OSBPL9", "P4HB", "PAFAH1B1", "PAICS", "PBRM1", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHGDH", "PHIP", "PI4KB", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PNP", "PNPLA6", "POLD1", "POLR1B", "POLR1C", "POLR2B", "POLR2E", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RCL1", "RDH13", "RDX", "RECQL5", "RIOK2", "RNF114", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSF1", "RTN4IP1", "S100A10", "S100A11", "SART1", "SBDS", "SCD", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A4", "SLIT2", "SMARCA4", "SMU1", "SNRNP40", "SNU13", "SPATA5", "SPTBN1", "SRCAP", "SRM", "STMN1", "STRN4", "STX12", "STX18", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SYNE2", "TAP1", "TAP2", "TBL3", "TCP1", "THOC6", "TK1", "TLN1", "TMX1", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TSFM", "TSPAN6", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UHRF1", "USP10", "USP14", "USP36", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4B", "WARS", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR36", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2"], "leading_proteins": ["ABCB1", "ACTR1A", "AK1", "AK2", "ALDH1A2", "ALDH1B1", "ALDH3A2", "ANXA1", "ANXA11", "ANXA7", "CALR", "CBX1", "CBX3", "CLGN", "COPZ1", "DNAJC10", "DNM1L", "EEF1B2", "HADH", "HMGA1", "HMGB2", "HMOX2", "IDH2", "KDSR", "LBR", "MPP2", "P4HB", "PFN1", "PSMB1", "PSMB2", "PSMB4", "PSMB6", "PSMB7", "RDH13", "RPSA", "STX12", "STX18", "TMX4", "TUBB", "TUBB4B", "TUBB6", "YWHAG", "YWHAH", "YWHAQ", "ZADH2"]} \ No newline at end of file diff --git a/interpro_domain/advanced/idx2term.json b/interpro_domain/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..082e928624676f0ddc62195bb4d4a8e97cbc3560 --- /dev/null +++ b/interpro_domain/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "EF-hand domain [IPR002048]"} \ No newline at end of file diff --git a/interpro_domain/advanced/plot_0.png b/interpro_domain/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..1a695031d1e5e8b49aedb6e88d31b4eabb29cbbc --- /dev/null +++ b/interpro_domain/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:fdef971a1402486b177984e55da616570fc6feab2914b44a9c76066b21d0e4d9 +size 196795 diff --git a/interpro_domain/basic/idx2term.json b/interpro_domain/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..2aac105a4214c8d058207df1bed0a576d23e6a10 --- /dev/null +++ b/interpro_domain/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "EF-hand domain [IPR002048]", "1": "RNA recognition motif domain [IPR000504]", "2": "FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]", "3": "DnaJ domain [IPR001623]", "4": "Proteasome component (PCI) domain [IPR000717]"} \ No newline at end of file diff --git a/interpro_domain/basic/plot_0.png b/interpro_domain/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..5a8e9c9e0be526c7f7614c3c77fb3cd15a354048 --- /dev/null +++ b/interpro_domain/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:fa17298b4a35a77d2b6a4b5d0da6db893d81856d44d08a5da247f1ec22171a7b +size 130563 diff --git a/interpro_domain/basic/plot_1.png b/interpro_domain/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..3f23c711bd295b8ff4a87439530cc1f518a0eee4 --- /dev/null +++ b/interpro_domain/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:b8858aa1f14684c705e70589a08fb41c478561b0f284d26685d07c1b7f50ad87 +size 142782 diff --git a/interpro_domain/basic/plot_2.png b/interpro_domain/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..5211afd4343e28ca904b5b3aecabf2828598547a --- /dev/null +++ b/interpro_domain/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:d14f2b8cc36b295c65855e92f7cfb85eccf38d1123f11ab7bfd15b592648ab7c +size 144379 diff --git a/interpro_domain/basic/plot_3.png b/interpro_domain/basic/plot_3.png new file mode 100644 index 0000000000000000000000000000000000000000..335a63e378b91048b37d32f434e4e4a0606360f5 --- /dev/null +++ b/interpro_domain/basic/plot_3.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:c3542690accf3329ac80e317ded11735118ecf75b06b0b9f209353a22d08aae7 +size 141585 diff --git a/interpro_domain/basic/plot_4.png b/interpro_domain/basic/plot_4.png new file mode 100644 index 0000000000000000000000000000000000000000..8c78f321bc4bfeeb1a1e8ef5cd7a1773dd04a242 --- /dev/null +++ b/interpro_domain/basic/plot_4.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:36b93d3a5b3fd1087c368b6e8cd3c78f93bb1d59cc1dfbf9655f9cbc0c5a8481 +size 152200 diff --git a/interpro_domain/consensus.joblib b/interpro_domain/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..393daddd5eeb84c6b92d7bdbf2dbf4088f796784 --- /dev/null +++ b/interpro_domain/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:d73fc3bbe8cd7df3b9aca6ff1224b5c0ad7869ee056ebbe1ddf08b2bbfb7b3af +size 350648 diff --git a/interpro_domain/df_merge.tsv b/interpro_domain/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..f3a57a0ba6b78f636bdd33a202bb182fb17fc599 --- /dev/null +++ b/interpro_domain/df_merge.tsv @@ -0,0 +1,5 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +EF-hand domain [IPR002048] 10 37 2.218680806632741 0.0265084477027324 12.385922330097088 43.512135922330096 1.0171858714399242 0.3947118087831401 4.608360476919044 4.087317384177653 1.201458704248258 0.3652478399429377 1.0 0.0832266786690803 0.2534337902702077 0.0104482115740687 0.0029592657664503 +Isopropylmalate dehydrogenase-like domain [IPR024084] 1 5 2.10981464482015 0.0348743245356633 1.8349514563106797 4.495145631067961 -0.0268416016144192 0.3268992301433215 1.18113888908689 0.4999764345469411 1.4254920509394828 0.309635855483207 1.0 0.0002241871259369 0.0009157120850054 0.0055254488719224 0.0209220238917207 +Aminopeptidase N-like , N-terminal domain [IPR045357] 2 6 2.0476699020294555 0.0405923549015689 2.121359223300971 5.466019417475728 1.4317001483019938 0.1783942022754649 1.021530403905949 0.5881604361499402 0.986353205880356 0.2226891741813114 1.0 0.0378187125466048 4.800413077288208e-05 0.0007102815399137 0.0003159986655096 +Peptidase M1, membrane alanine aminopeptidase [IPR014782] 2 6 2.0476699020294555 0.0405923549015689 2.121359223300971 5.466019417475728 1.4317001483019938 0.1783942022754649 1.021530403905949 0.5881604361499402 0.986353205880356 0.2226891741813114 1.0 0.0378187125466048 4.800413077288208e-05 0.0007102815399137 0.0003159986655096 diff --git a/interpro_domain/metrics.json b/interpro_domain/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..413d16226aefb2ff00044e2e92a427ad03730c7e --- /dev/null +++ b/interpro_domain/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2454, + "annotations_size": 2199, + "title": "Average number of proteins per term", + "value": 2.050022737608004 +} \ No newline at end of file diff --git a/interpro_domain/paths.json b/interpro_domain/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..644aa076356b8e822c650770d23cfb2ccd77db20 --- /dev/null +++ b/interpro_domain/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C340/C340_val_log2fc"} \ No newline at end of file diff --git a/interpro_domain/result.tsv b/interpro_domain/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..156acac1f7ee6d71685b1c7ad0ae25ca21a1bf59 --- /dev/null +++ b/interpro_domain/result.tsv @@ -0,0 +1,145 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Tubulin/FtsZ, 2-layer sandwich domain [IPR018316] 0.9726530612244896 2.317108644920705 0.0204978142125638 1.0 0.0856933335616498 4 Q9BUF5,P07437,P68371 3 +Tubulin/FtsZ, GTPase domain [IPR003008] 0.9726530612244896 2.317108644920705 0.0204978142125638 1.0 0.0856933335616498 4 Q9BUF5,P07437,P68371 3 +EF-hand domain [IPR002048] 0.530961463799274 2.218680806632741 0.0265084477027324 1.0 0.0995758100683796 37 Q02818,Q9Y680,Q9BRK5,P80303,P30626,P60660,Q6NUK1,Q14257,Q9NWM8,O43852 10 +ERAP1-like C-terminal domain [IPR024571] 0.944639847254494 2.208493834385211 0.0272098671403557 1.0 0.100560601985746 4 Q9UIQ6,P55786 2 +TRAM/LAG1/CLN8 homology domain [IPR006634] 0.9677814029363774 2.141800408539122 0.0322095465498275 1.0 0.1130707386926124 2 Q96G23 1 +Isopropylmalate dehydrogenase-like domain [IPR024084] 0.8873152080167173 2.10981464482015 0.0348743245356633 1.0 0.1189978458648424 5 P48735 1 +Aminopeptidase N-like , N-terminal domain [IPR045357] 0.8487956553260017 2.0476699020294555 0.0405923549015689 1.0 0.1306919303492682 6 Q9UIQ6,P55786 2 +Peptidase M1, membrane alanine aminopeptidase [IPR014782] 0.8487956553260017 2.0476699020294555 0.0405923549015689 1.0 0.1306919303492682 6 Q9UIQ6,P55786 2 +3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176] 0.9396411092985296 2.0245803127813957 0.04291047749655 1.0 0.1363585838365804 2 Q16836 1 +3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108] 0.9396411092985296 2.0245803127813957 0.04291047749655 1.0 0.1363585838365804 2 Q16836 1 +Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547] 0.9282218597063596 1.9767220324643264 0.0480730589506812 1.0 0.1458105608724801 2 O15460 1 +MD-2-related lipid-recognition domain [IPR003172] 0.921288743882542 1.9475874080892863 0.0514643516468977 1.0 0.1519061869416486 2 P17900 1 +L27 domain, C-terminal [IPR014775] 0.9102773246329496 1.901198589597285 0.0572760057708205 1.0 0.1601909766371808 2 Q14168 1 +L27 domain [IPR004172] 0.9102773246329496 1.901198589597285 0.0572760057708205 1.0 0.1601909766371808 2 Q14168 1 +Post-SET domain [IPR003616] 0.9041598694942864 1.8753676346288648 0.0607421645252332 1.0 0.1659149542919129 2 Q03164 1 +RNA recognition motif domain [IPR000504] 0.378074170879189 1.8015209851561067 0.0716208027380918 1.0 0.1818639090312515 103 Q13242,Q14011,Q9UHX1,Q8WXF1,Q99729,Q92804,Q76FK4,Q16630,Q01844,P09651,Q8IY67,Q9BWF3,P31483,P33240,P98175,Q86V81,Q9NW64,Q9P2N5,P51991,P62995,P84103,P52597,P38159,Q96I25,P31943,Q01085,O60506,P23246,P52756,Q9Y5S9,P55795,Q07955,P31942,Q15233,Q13151,Q14103,O43390,Q15056,P26368,P22626,P35637,Q12849,O75494,Q96EP5,O14979,Q96PK6 46 +Peptidase M16, C-terminal [IPR007863] 0.7370053953010196 1.7846845193587506 0.0743125033406748 1.0 0.1865447429750502 7 O43847,P22695,P31930 3 +Peptidase M16, N-terminal [IPR011765] 0.7370053953010196 1.7846845193587506 0.0743125033406748 1.0 0.1865447429750502 7 O43847,P22695,P31930 3 +Cytochrome b5-like heme/steroid binding domain [IPR001199] 0.7235262421569126 1.7248398151995277 0.0845563442326717 1.0 0.2016696322859492 7 Q8WUJ1,O43169 2 +CARG-binding factor, N-terminal [IPR012956] 0.8584828711256134 1.6813127852766698 0.0927021757953812 1.0 0.2138827848523954 2 Q99729 1 +Fzo/mitofusin HR2 domain [IPR006884] 0.8552202283849897 1.6673827907161785 0.0954383136064214 1.0 0.2183859017903441 2 Q8IWA4 1 +Polyketide synthase, enoylreductase domain [IPR020843] 0.7454167904723265 1.6177321585524065 0.1057203323735573 1.0 0.2327117226120647 6 Q8N4Q0,Q8WWV3 2 +EB1, C-terminal [IPR004953] 0.8417618270799367 1.6098450380566791 0.1074316901858076 1.0 0.2346000861157806 2 Q15555 1 +Chromo domain [IPR023780] 0.7820704257969376 1.555665654831928 0.119787617623607 1.0 0.2544447821921686 4 Q13185,P83916 2 +FAD linked oxidase, N-terminal [IPR006094] 0.8201468189233188 1.5172299880830096 0.1292086275019155 1.0 0.2662884459950443 2 Q15392 1 +FAD-binding domain, PCMH-type [IPR016166] 0.8201468189233188 1.5172299880830096 0.1292086275019155 1.0 0.2662884459950443 2 Q15392 1 +NECAP, PHear domain [IPR012466] 0.816884176182707 1.5032344200080852 0.1327786045219285 1.0 0.2708535726750658 2 Q9NVZ3 1 +Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337] 0.8058727569331184 1.455980892087177 0.1453979018861548 1.0 0.2848490006824648 2 O60506 1 +RNA recognition motif domain, eukaryote [IPR003954] 0.5554846707895763 1.4066507766796772 0.1595309684809702 1.0 0.3002327704783304 12 P31483,Q14011,Q9UHX1,Q01085 4 +Alcohol dehydrogenase, N-terminal [IPR013154] 0.7164092991088973 1.4034084501435753 0.1604950746135216 1.0 0.3008769557332771 5 Q8N4Q0 1 +Reticulon [IPR003388] 0.7915986949428915 1.3947091429242993 0.1631035666761513 1.0 0.3025521889093968 2 O95197 1 +Chromo domain subgroup [IPR017984] 0.8494492044063684 1.37645728993164 0.1686801015807824 1.0 0.3091062861467837 3 Q13185,P83916 2 +Chromo shadow domain [IPR008251] 0.8494492044063684 1.37645728993164 0.1686801015807824 1.0 0.3091062861467837 3 Q13185,P83916 2 +Guanylate kinase/L-type calcium channel beta subunit [IPR008145] 0.7374326042682576 1.3712656051135812 0.1702921735319846 1.0 0.3115411727095127 4 Q14168 1 +Guanylate kinase-like domain [IPR008144] 0.7374326042682576 1.3712656051135812 0.1702921735319846 1.0 0.3115411727095127 4 Q14168 1 +OCRE domain [IPR041591] 0.7577487765089719 1.2496015075705116 0.2114451521464175 1.0 0.3571181947542029 2 P98175 1 +Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862] 0.8097955485409687 1.22265608465917 0.2214596203344563 1.0 0.3680950152044365 3 O15460 1 +Marvel domain [IPR008253] 0.744698205546495 1.1938524607785177 0.2325356862663188 1.0 0.3786605213089629 2 O43760 1 +GOLD domain [IPR009038] 0.6922448979591808 1.1838762639886198 0.2364620473344807 1.0 0.3806588887910125 4 Q9Y3B3,Q9H3P7,P49755 3 +Far upstream element-binding protein, C-terminal [IPR015096] 0.7373572593800987 1.1625723546090996 0.245003052663109 1.0 0.3884367071421606 2 Q96AE4 1 +14-3-3 domain [IPR023410] 0.6347601898743878 1.1426666095990483 0.2531770382339848 1.0 0.3982377017714826 6 P61981,P27348,Q04917 3 +Dynamin-type guanine nucleotide-binding (G) domain [IPR030381] 0.6328978718167115 1.1346218405662776 0.2565337980958255 1.0 0.4003675103000144 6 Q8IWA4 1 +Dynamin, N-terminal [IPR045063] 0.6328978718167115 1.1346218405662776 0.2565337980958255 1.0 0.4003675103000144 6 Q8IWA4 1 +Target SNARE coiled-coil homology domain [IPR000727] 0.667224418404735 1.0803661544198857 0.2799791612906099 1.0 0.423051500752052 4 Q9UNK0,O95721 2 +SET domain [IPR001214] 0.7674006701798807 1.0592500979631432 0.2894858948065049 1.0 0.4292511683610952 3 Q03164 1 +Zinc finger C2H2 AKAP95-type [IPR034736] 0.7120717781402975 1.055431335949665 0.29122809764737 1.0 0.4306728895269446 2 Q9ULX6 1 +Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038] 0.7096247960848292 1.0451239726075388 0.2959656757463005 1.0 0.4332585524983041 2 P24534 1 +Elongation factor 1 beta central acidic region, eukaryote [IPR018940] 0.7096247960848292 1.0451239726075388 0.2959656757463005 1.0 0.4332585524983041 2 P24534 1 +Fragile X-related 1 protein, C-terminal region 1 [IPR032172] 0.7092169657422516 1.0434072988357477 0.2967596945501372 1.0 0.4336194606475783 2 P51114 1 +Zinc finger, CHHC-type [IPR012996] 0.7572419420644685 1.020407065811077 0.3075354442037334 1.0 0.4434560274124655 3 P52597,P31943 2 +LEM domain [IPR003887] 0.6238487538961888 1.0108099325686115 0.3121074082845871 1.0 0.446534932217181 5 Q9Y2U8,Q86XL3 2 +NOPS [IPR012975] 0.754385964912281 1.0095163671466845 0.3127270561959967 1.0 0.4471305569408302 3 Q8WXF1,P23246 2 +Zinc finger, RanBP2-type [IPR001876] 0.5094374431513398 0.9557446505302828 0.3392012581445858 1.0 0.4729889452504401 9 P35637,Q92804 2 +Ancestral coatomer element 1, Sec16/Sec31 [IPR024298] 0.6859706362153364 0.9462158300471588 0.3440385136618098 1.0 0.4779804953973415 2 O15027 1 +CSN8/PSMD8/EIF3K [IPR033464] 0.7265086603774438 0.9040418891982872 0.3659731898995677 1.0 0.496774718882191 3 Q99627 1 +U2A'/phosphoprotein 32 family A, C-terminal [IPR003603] 0.6725122349102785 0.8906525976750244 0.3731155723858286 1.0 0.5046009493705025 2 Q92688 1 +Fragile X-related 1 protein, C-terminal core [IPR022034] 0.7095063239494073 0.8406258604223189 0.4005575665772056 1.0 0.5264949724466678 3 P51114,Q06787 2 +Synaptic functional regulator FMRP, KH0 domain [IPR040472] 0.7095063239494073 0.8406258604223189 0.4005575665772056 1.0 0.5264949724466678 3 P51114,Q06787 2 +Fxr1, tudor domain [IPR041560] 0.7095063239494073 0.8406258604223189 0.4005575665772056 1.0 0.5264949724466678 3 P51114,Q06787 2 +Agenet-like domain [IPR008395] 0.7095063239494073 0.8406258604223189 0.4005575665772056 1.0 0.5264949724466678 3 P51114,Q06787 2 +ABC transporter type 1, transmembrane domain [IPR011527] 0.5640427011505411 0.8392374562165842 0.4013360722994201 1.0 0.5270467462015089 6 P08183 1 +FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179] 0.4692481916726755 0.7559471567258431 0.4496808790472157 1.0 0.5670001450830433 9 Q9Y680,Q00688,P26885,Q9NWM8,Q96AY3 5 +Metaxin, glutathione S-transferase domain [IPR033468] 0.6743892552988815 0.7126305448747322 0.4760744054612253 1.0 0.5845193356496229 3 Q13505 1 +Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564] 0.6743892552988815 0.7126305448747322 0.4760744054612253 1.0 0.5845193356496229 3 Q13505 1 +SH3 domain [IPR001452] 0.3786273874628865 0.6901578266901605 0.4900949413376743 1.0 0.5927362915591093 22 Q9UQB8,Q14168,Q9NZW5 3 +EF hand associated, type-1 [IPR013566] 0.6211256117455195 0.6853804047367859 0.4931039059249764 1.0 0.5935060148489454 2 Q8IXI1 1 +EF hand associated, type-2 [IPR013567] 0.6211256117455195 0.6853804047367859 0.4931039059249764 1.0 0.5935060148489454 2 Q8IXI1 1 +MIRO domain [IPR020860] 0.6211256117455195 0.6853804047367859 0.4931039059249764 1.0 0.5935060148489454 2 Q8IXI1 1 +Peptidase C2, calpain, catalytic domain [IPR001300] 0.619086460032632 0.6775200537153125 0.4980760508708892 1.0 0.5958825431747543 2 P17655 1 +Peptidase C2, calpain, domain III [IPR022683] 0.619086460032632 0.6775200537153125 0.4980760508708892 1.0 0.5958825431747543 2 P17655 1 +Peptidase C2, calpain, large subunit, domain III [IPR022682] 0.619086460032632 0.6775200537153125 0.4980760508708892 1.0 0.5958825431747543 2 P17655 1 +Calpain subdomain III [IPR033883] 0.619086460032632 0.6775200537153125 0.4980760508708892 1.0 0.5958825431747543 2 P17655 1 +Tyrosine-protein kinase, catalytic domain [IPR020635] 0.6141924959217027 0.6587622194579056 0.5100484716271583 1.0 0.6039830851416914 2 Q15375 1 +UBX domain [IPR001012] 0.6541436803673615 0.6411781449286058 0.5214069473390364 1.0 0.6123192273976081 3 Q9UNZ2 1 +Death domain [IPR000488] 0.6483068135454905 0.6209607671148147 0.534625437143172 1.0 0.6213749134660863 3 Q96FV9,Q12955 2 +Ricin B, lectin domain [IPR000772] 0.6393308853529265 0.5902397891383343 0.5550298999112839 1.0 0.6367370341206156 3 Q9UMS4,Q10472 2 +Prolyl 4-hydroxylase, alpha subunit [IPR006620] 0.4679617290939928 0.5703474394750994 0.5684420710832585 1.0 0.646590998859427 7 O15460 1 +Oxoglutarate/iron-dependent dioxygenase [IPR005123] 0.4679617290939928 0.5703474394750994 0.5684420710832585 1.0 0.646590998859427 7 O15460 1 +Legume-like lectin [IPR005052] 0.5840130505709693 0.5468256479520451 0.5844985207016271 1.0 0.6593845243675468 2 Q12907 1 +B-box-type zinc finger [IPR000315] 0.5318367346938727 0.5449339288798186 0.5857989600253113 1.0 0.6593845243675468 4 Q13263,Q12899,Q9UPN9 3 +Serine hydroxymethyltransferase-like domain [IPR039429] 0.5469004893964198 0.4199294669115569 0.6745369806684534 1.0 0.737596628786638 2 P34897 1 +DnaJ domain [IPR001623] 0.3604006109650538 0.4078942192512672 0.6833513369557811 1.0 0.7453817410544458 14 Q99543,Q8WXX5,O75937,Q13217,Q8IXB1 5 +Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091] 0.4180154910765672 0.3677531167506733 0.7130573302364904 1.0 0.7747100144219577 7 P16219 1 +Zinc finger, CCCH-type [IPR000571] 0.3724302655116486 0.3655178865047098 0.7147248576069178 1.0 0.7761382527790678 11 Q9NW64,Q9P2N5,Q8IWR0,Q96GM8 4 +Glucosamine/galactosamine-6-phosphate isomerase [IPR006148] 0.5289559543230089 0.3637673959912566 0.7160317112522443 1.0 0.7771736095970806 2 O95336 1 +Aldehyde dehydrogenase domain [IPR015590] 0.3824266676754498 0.3521192955933475 0.7247487981414227 1.0 0.7846984771605064 9 O94788,P51648,P30837 3 +Ribosomal protein S10 domain [IPR027486] 0.5224306688417732 0.3442930217434618 0.7306259317158899 1.0 0.7895068421834113 2 P60866 1 +PITH domain [IPR010400] 0.5154975530179531 0.3241863244071596 0.7457969750202127 1.0 0.8027447616590542 2 Q9GZP4 1 +Alcohol dehydrogenase-like, C-terminal [IPR013149] 0.4310577740559467 0.3202428681169919 0.7487842288489137 1.0 0.805171892048294 6 Q8N4Q0 1 +GTPase effector domain [IPR020850] 0.5097879282218654 0.3080940396808397 0.7580107764364625 1.0 0.8123127180232852 2 O00429 1 +Dynamin GTPase effector [IPR003130] 0.5097879282218654 0.3080940396808397 0.7580107764364625 1.0 0.8123127180232852 2 O00429 1 +Dynamin stalk domain [IPR000375] 0.5097879282218654 0.3080940396808397 0.7580107764364625 1.0 0.8123127180232852 2 O00429 1 +Chromo/chromo shadow domain [IPR000953] 0.4266589186549413 0.305547316920649 0.7599493380829627 1.0 0.8139934702603191 6 Q13185,P83916 2 +FCP1 homology domain [IPR004274] 0.5081566068515619 0.3035752121107942 0.7614515387167815 1.0 0.8148087268312421 2 Q05D32 1 +Proteasome component (PCI) domain [IPR000717] 0.3297196784467691 0.2992611587260076 0.7647407881526767 1.0 0.8179304441380039 17 P60228,Q99627,P48556,Q9BT78,Q7L2H7 5 +AP complex, mu/sigma subunit [IPR022775] 0.437174282004364 0.2939874609439734 0.7687674849348043 1.0 0.8206798604572533 5 P61923 1 +PDZ domain [IPR001478] 0.3404866415315078 0.2887064698968115 0.7728060111825465 1.0 0.8241515124104849 13 Q14168,Q9NZW5 2 +Peroxiredoxin, C-terminal [IPR019479] 0.4497959183673415 0.2755580446681805 0.7828875378779225 1.0 0.8332863968023 4 P32119,P30041,P30048 3 +Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant [IPR000866] 0.4497959183673415 0.2755580446681805 0.7828875378779225 1.0 0.8332863968023 4 P32119,P30041,P30048 3 +B-box, C-terminal [IPR003649] 0.5316197470420256 0.2692939052029608 0.78770352195051 1.0 0.8375178319333667 3 Q13263,Q9UPN9 2 +Ubiquitin system component CUE [IPR003892] 0.5314604047303941 0.2689013002981928 0.7880056363211168 1.0 0.8375178319333667 3 Q9Y679 1 +PTBP1, RNA recognition motif 2-like [IPR021790] 0.5303957568339488 0.2662854603523814 0.7900193699443316 1.0 0.8388472209114367 3 Q8WVV9,P26599 2 +CRIB domain [IPR000095] 0.4926590538336183 0.262450587753067 0.792974075683069 1.0 0.840097429815647 2 O96013 1 +p21 activated kinase binding domain [IPR033923] 0.4926590538336183 0.262450587753067 0.792974075683069 1.0 0.840097429815647 2 O96013 1 +ENTH domain [IPR013809] 0.492251223491031 0.2614133905523975 0.7937737317963602 1.0 0.840097429815647 2 Q13492 1 +Proteasome activator PA28, C-terminal domain [IPR003186] 0.5273289556283682 0.2588222087647908 0.7957724214885944 1.0 0.8408955093000572 3 Q9UL46 1 +Proteasome activator PA28, N-terminal domain [IPR003185] 0.5273289556283682 0.2588222087647908 0.7957724214885944 1.0 0.8408955093000572 3 Q9UL46 1 +Syntaxin, N-terminal domain [IPR006011] 0.4816476345840199 0.235279865916175 0.8139915212136193 1.0 0.8568536884388458 2 Q86Y82 1 +SH2 domain [IPR000980] 0.4127032459666241 0.2218356947274076 0.8244417912982387 1.0 0.8666097031858637 5 Q7KZ85 1 +Dynamin, GTPase domain [IPR001401] 0.5099959200326435 0.2186946807741671 0.8268878928223689 1.0 0.8683507527776452 3 O00429,O60313 2 +Glutathione S-transferase, N-terminal [IPR004045] 0.3948965323409548 0.2067602914739015 0.8361970688127103 1.0 0.8764525044419209 6 Q9H7Z7 1 +60S ribosomal protein L10P, insertion domain [IPR040637] 0.4624796084828763 0.1922142527944003 0.8475743819519233 1.0 0.8866869961523688 2 Q9UKD2 1 +C-CAP/cofactor C-like domain [IPR017901] 0.4592169657422552 0.1854305609697427 0.8528913398614397 1.0 0.8914011674692519 2 O75695 1 +CARP motif [IPR006599] 0.4592169657422552 0.1854305609697427 0.8528913398614397 1.0 0.8914011674692519 2 O75695 1 +ABC transporter-like, ATP-binding domain [IPR003439] 0.3360751075974014 0.1711004517138927 0.8641447806939491 1.0 0.90187677871191 9 P08183 1 +Staufen, C-terminal [IPR032478] 0.4506525285481258 0.1683888267852185 0.8662773975326201 1.0 0.9036736229479276 2 O95793 1 +Dual specificity protein phosphatase domain [IPR020422] 0.4420880913539993 0.1524586526690709 0.8788251995421921 1.0 0.9156025498162766 2 Q99956 1 +Dual specificity phosphatase, catalytic domain [IPR000340] 0.4420880913539993 0.1524586526690709 0.8788251995421921 1.0 0.9156025498162766 2 Q99956 1 +Domain of unknown function DUF4749 [IPR031847] 0.4416802610114196 0.1517277973296535 0.8794016318981703 1.0 0.9156025498162766 2 Q96HC4 1 +Immunoglobulin V-set domain [IPR013106] 0.4404567699836864 0.1495503341162671 0.8811193950062448 1.0 0.9164622617688024 2 Q9Y624 1 +RING-type zinc-finger, LisH dimerisation motif [IPR027370] 0.4704202366381086 0.1408059974326015 0.8880232050074126 1.0 0.9228558732567582 3 Q9UPN9,O15344 2 +HDGF-related, PWWP domain [IPR035496] 0.4638922888617001 0.1298505413594051 0.8966846751576705 1.0 0.9296603492087304 3 P51858,Q7Z4V5 2 +Nucleotidyl transferase domain [IPR005835] 0.4143556280587285 0.1084386695874087 0.9136477280774726 1.0 0.9450194515721364 2 Q96IJ6 1 +SCP2 sterol-binding domain [IPR003033] 0.4475724194206439 0.1048161421424636 0.9165217010295909 1.0 0.9471011374831156 3 P22307,Q6YN16 2 +Exportin-2, central domain [IPR013713] 0.4447164422684638 0.1007782577984135 0.9197264867191666 1.0 0.9499664369635732 3 O15397,P55060 2 +Lamin tail domain [IPR001322] 0.4283965728274241 0.0796273941586637 0.9365336070019998 1.0 0.965512143364931 3 P20700,Q03252 2 +Tyrosine-specific protein phosphatases domain [IPR000387] 0.4263565891472868 0.0772098447773083 0.938456610027922 1.0 0.9670412771562326 3 P51452,Q99956 2 +Heat shock chaperonin-binding [IPR006636] 0.4247246022031825 0.075311342209227 0.9399669973345108 1.0 0.96814399397592 3 Q9NRR5,P54727 2 +PWI domain [IPR002483] 0.3470804409963287 0.07215289031026 0.9424802354904316 1.0 0.9702781076046156 5 P49756,Q9P2N5,Q5T8P6,O43395 4 +DDE superfamily endonuclease domain [IPR004875] 0.362561174551386 0.0548991693614683 0.9562187936362204 1.0 0.9804588643794442 2 P07199 1 +HTH CenpB-type DNA-binding domain [IPR006600] 0.362561174551386 0.0548991693614683 0.9562187936362204 1.0 0.9804588643794442 2 P07199 1 +ERM family, FERM domain C-lobe [IPR041789] 0.4010607915136749 0.0512165369805654 0.9591529745335116 1.0 0.9821003237237764 3 P26038,P35241 2 +Intermediate filament head, DNA-binding domain [IPR006821] 0.3352851606690825 0.0438251327678045 0.965043793275437 1.0 0.985662471626886 4 P08670 1 +PWWP domain [IPR000313] 0.3240517958286456 0.041931532276672 0.9665532793744284 1.0 0.98638039762219 6 O96028 1 +Thioesterase domain [IPR006683] 0.3409461663947814 0.0418179587821896 0.9666438184974168 1.0 0.98638039762219 2 O00154 1 +Ubiquitin-associated domain [IPR015940] 0.2936125829290161 0.0408246072998019 0.9674357219203352 1.0 0.9867305902146648 9 Q13501 1 +Endonuclease/exonuclease/phosphatase [IPR005135] 0.3269387755101985 0.0345088477381227 0.972471387077021 1.0 0.9900298982325784 4 Q6L8Q7,O95551,Q9ULM6 3 +Brix domain [IPR007109] 0.343533251733981 0.0157720472556526 0.987416248721656 1.0 1.0 3 Q9NQ55,Q9H7B2 2 +Sterile alpha motif domain [IPR001660] 0.2991836734693837 0.0100717080758427 0.9919640754853656 1.0 1.0 4 Q15375,Q8IXK0,Q9Y3Z3 3 +Zinc finger, C3HC4 RING-type [IPR018957] 0.313749490004077 0.0070003422550446 0.9944145806131202 1.0 1.0 3 P38398,Q5VTR2 2 +Flavoprotein pyridine nucleotide cytochrome reductase [IPR001709] 0.3133414932680503 0.0069124818985344 0.9944846813388976 1.0 1.0 3 P16435,Q9UHQ9 2 +Oxidoreductase FAD/NAD(P)-binding [IPR001433] 0.3133414932680503 0.0069124818985344 0.9944846813388976 1.0 1.0 3 P16435,Q9UHQ9 2 +FAD-binding domain, ferredoxin reductase-type [IPR017927] 0.3133414932680503 0.0069124818985344 0.9944846813388976 1.0 1.0 3 P16435,Q9UHQ9 2 +F-box domain [IPR001810] 0.2986536107711117 0.0042174984773395 0.9966349330556296 1.0 1.0 3 Q14241,Q9Y2K7 2 diff --git a/interpro_domain/selections.json b/interpro_domain/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..389df473f60d829de75df7f4ea4bcfbb9666d706 --- /dev/null +++ b/interpro_domain/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1-acyl-sn-glycerol-3-phosphate acyltransferase [IPR004552]", "116kDa U5 small nuclear ribonucleoprotein component, C-terminal [IPR035655]", "116kDa U5 small nuclear ribonucleoprotein component, N-terminal [IPR031950]", "14-3-3 domain [IPR023410]", "18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23, C-terminal [IPR022238]", "2-oxoacid dehydrogenase acyltransferase, catalytic domain [IPR001078]", "2-oxoglutarate dehydrogenase E1 component, N-terminal domain [IPR032106]", "26S proteasome non-ATPase regulatory subunit RPN1, C-terminal [IPR041433]", "26S proteasome regulatory subunit RPN2, C-terminal [IPR040623]", "26S proteasome regulatory subunit RPN5, C-terminal domain [IPR040896]", "26S proteasome regulatory subunit Rpn6, N-terminal [IPR040773]", "26S proteasome regulatory subunit Rpn7, N-terminal [IPR045135]", "26S proteasome regulatory subunit, C-terminal [IPR013586]", "2Fe-2S ferredoxin-type iron-sulfur binding domain [IPR001041]", "3'-5' exonuclease domain [IPR002562]", "3-beta hydroxysteroid dehydrogenase/isomerase [IPR002225]", "3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108]", "3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176]", "3-hydroxyisobutyrate dehydrogenase, NAD-binding domain [IPR029154]", "3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal [IPR001104]", "4'-phosphopantetheinyl transferase domain [IPR008278]", "40S ribosomal protein S11, N-terminal [IPR032440]", "40S ribosomal protein S4, C-terminal domain [IPR032277]", "40S ribosomal protein SA, C-terminal domain [IPR032281]", "4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]", "6-phosphogluconate dehydrogenase, C-terminal [IPR006114]", "6-phosphogluconate dehydrogenase, NADP-binding [IPR006115]", "6-phosphogluconolactonase, DevB-type [IPR005900]", "60S ribosomal protein L10P, insertion domain [IPR040637]", "60S ribosomal protein L4, C-terminal domain [IPR025755]", "6S proteasome subunit Rpn6, C-terminal helix domain [IPR040780]", "A kinase-anchoring protein AKAP5 and AKAP12, calmodulin (CaM)-binding motif [IPR001573]", "AAA ATPase, AAA+ lid domain [IPR041569]", "AAA+ ATPase domain [IPR003593]", "AARP2CN [IPR012948]", "AATF leucine zipper-containing domain [IPR025160]", "ABC transporter type 1, transmembrane domain [IPR011527]", "ABC transporter-like, ATP-binding domain [IPR003439]", "ABC-transporter extension domain [IPR032781]", "ADAM10/ADAM17 catalytic domain [IPR034025]", "ADAM17, membrane-proximal domain [IPR032029]", "ADAR1, first double-stranded RNA binding domain [IPR044456]", "ADAR1, third double-stranded RNA binding domain [IPR044457]", "ADNP, zinc finger domain [IPR045762]", "AGC-kinase, C-terminal [IPR000961]", "AIMP2, lysyl-tRNA synthetase binding domain [IPR031889]", "AIMP2, thioredoxin-like domain [IPR041503]", "ALIX V-shaped domain [IPR025304]", "AMP-binding enzyme, C-terminal domain [IPR025110]", "AMP-dependent synthetase/ligase [IPR000873]", "AP complex, mu/sigma subunit [IPR022775]", "AP-2 complex subunit mu, N-terminal [IPR043532]", "AP-3 complex subunit beta 1, serine-rich domain [IPR029394]", "AP-3 complex subunit beta, C-terminal domain [IPR029390]", "AP-3 complex subunit delta domain, metazoa [IPR010474]", "AP180 N-terminal homology (ANTH) domain [IPR011417]", "APC10/DOC domain [IPR004939]", "ARHGEF1-like, PH domain [IPR041020]", "ARHGEF2, PH domain [IPR037806]", "ARID DNA-binding domain [IPR001606]", "ATP synthase, F1 complex, alpha subunit nucleotide-binding domain [IPR033732]", "ATP synthase, alpha subunit, C-terminal [IPR000793]", "ATP-citrate lyase/succinyl-CoA ligase [IPR005811]", "ATP-citrate synthase, citrate-binding domain [IPR032263]", "ATP-cone domain [IPR005144]", "ATP-dependent DNA helicase RecQ, zinc-binding domain [IPR032284]", "ATP-dependent RNA helicase Ski2, C-terminal [IPR012961]", "ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain [IPR044728]", "ATP-dependent helicase, C-terminal [IPR006555]", "ATP-grasp fold [IPR011761]", "ATP-grasp fold, succinyl-CoA synthetase-type [IPR013650]", "ATP-sulfurylase PUA-like domain [IPR025980]", "ATP:guanido phosphotransferase, N-terminal [IPR022413]", "ATP:guanido phosphotransferase, catalytic domain [IPR022414]", "ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]", "ATPase, AAA-type, core [IPR003959]", "ATPase, BadF/BadG/BcrA/BcrD type [IPR002731]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain [IPR004100]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain [IPR000194]", "ATPase, V1 complex, subunit H, C-terminal [IPR011987]", "ATPase, dynein-related, AAA domain [IPR011704]", "ATPsynthase alpha/beta subunit, N-terminal extension [IPR031686]", "AWS domain [IPR006560]", "Acetyl-CoA carboxylase [IPR034733]", "Acetyl-CoA carboxylase, central domain [IPR013537]", "Acetyl-coA carboxylase zinc finger domain [IPR041010]", "Acetyl-coenzyme A carboxyltransferase, C-terminal [IPR011763]", "Acetyl-coenzyme A carboxyltransferase, N-terminal [IPR011762]", "Acid ceramidase, N-terminal [IPR029130]", "Acinus, RNA recognition motif [IPR034257]", "Aconitase A, swivel domain [IPR044137]", "Aconitase A/isopropylmalate dehydratase small subunit, swivel domain [IPR000573]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain [IPR001030]", "Actin-depolymerising factor homology domain [IPR002108]", "Activator of Hsp90 ATPase, N-terminal [IPR015310]", "Acyl transferase [IPR014043]", "Acyl-CoA dehydrogenase/oxidase C-terminal [IPR009075]", "Acyl-CoA dehydrogenase/oxidase, N-terminal [IPR013786]", "Acyl-CoA oxidase, C-terminal [IPR002655]", "Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091]", "Acyl-CoA-binding protein, ACBP [IPR000582]", "Acyl-coenzyme A oxidase, N-terminal [IPR029320]", "Acylamino-acid-releasing enzyme, N-terminal domain [IPR045550]", "Acylglycerol kinase, C-terminal [IPR045579]", "Adenosine deaminase/editase [IPR002466]", "Adenylate cyclase-associated CAP, C-terminal [IPR013912]", "Adenylate cyclase-associated CAP, N-terminal [IPR013992]", "Adenylate kinase, active site lid domain [IPR007862]", "Adenylosuccinate lyase C-terminal [IPR019468]", "Afadin, cargo binding domain [IPR037977]", "Agenet-like domain [IPR008395]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal [IPR007886]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain [IPR007698]", "Alanyl-tRNA synthetase, class IIc, N-terminal [IPR018164]", "Alanyl-tRNA synthetase, class IIc, core domain [IPR018165]", "Alcohol dehydrogenase, N-terminal [IPR013154]", "Alcohol dehydrogenase-like, C-terminal [IPR013149]", "Aldehyde dehydrogenase domain [IPR015590]", "Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant [IPR000866]", "Alpha Spectrin, SH3 domain [IPR035825]", "Alpha crystallin/Hsp20 domain [IPR002068]", "Alpha galactosidase A, C-terminal beta-sandwich domain [IPR035373]", "Alpha-2-macroglobulin RAP, C-terminal [IPR010483]", "Alpha-2-macroglobulin RAP, domain 2 [IPR038001]", "Alpha-2-macroglobulin RAP, domain 3 [IPR037999]", "Alpha-2-macroglobulin receptor-associated protein, domain 1 [IPR009066]", "Alpha-D-phosphohexomutase, C-terminal [IPR005843]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain I [IPR005844]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain II [IPR005845]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain III [IPR005846]", "Alpha-L-fucosidase, C-terminal [IPR031919]", "Alpha-N-acetylglucosaminidase, C-terminal [IPR024732]", "Alpha-N-acetylglucosaminidase, N-terminal [IPR024240]", "Alpha-N-acetylglucosaminidase, tim-barrel domain [IPR024733]", "Alpha-glycerophosphate oxidase, C-terminal [IPR031656]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like [IPR027450]", "Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal [IPR024366]", "Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain [IPR024367]", "Alpha/beta hydrolase fold-1 [IPR000073]", "Amidase signature domain [IPR023631]", "Amidohydrolase-related [IPR006680]", "Amidophosphoribosyltransferase, N-terminal [IPR035584]", "Amine oxidase [IPR002937]", "Amino acid permease, N-terminal [IPR013612]", "Amino acid permease/ SLC12A domain [IPR004841]", "Aminoacyl-tRNA synthetase, class II (D/K/N) [IPR004364]", "Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) [IPR002314]", "Aminoacyl-tRNA synthetase, class II [IPR006195]", "Aminoacyl-tRNA synthetase, class Ia [IPR002300]", "Aminomethyltransferase, folate-binding domain [IPR006222]", "Aminopeptidase N-like , N-terminal domain [IPR045357]", "Aminopeptidase P [IPR033740]", "Aminopeptidase P, N-terminal [IPR007865]", "Aminotransferase class V domain [IPR000192]", "Aminotransferase, class I/classII [IPR004839]", "Amyloidogenic glycoprotein, E2 domain [IPR024329]", "Amyloidogenic glycoprotein, amyloid-beta peptide [IPR013803]", "Amyloidogenic glycoprotein, copper-binding [IPR011178]", "Amyloidogenic glycoprotein, extracellular [IPR008154]", "Amyloidogenic glycoprotein, heparin-binding [IPR015849]", "Anaphase-promoting complex subunit 1, C-terminal [IPR041221]", "Anaphase-promoting complex subunit 4, WD40 domain [IPR024977]", "Anaphase-promoting complex subunit 5 domain [IPR026000]", "Ancestral coatomer element 1, Sec16/Sec31 [IPR024298]", "Angiomotin, C-terminal [IPR024646]", "Anillin homology domain [IPR012966]", "Anillin, N-terminal domain [IPR031970]", "Anillin, PH domain [IPR037840]", "Anion-transporting ATPase-like domain [IPR025723]", "Ankyrin repeat and LEM domain-containing protein 2, LEM domain [IPR035006]", "Ankyrin, UPA domain [IPR040745]", "Ankyrin-3, death domain [IPR037971]", "Anticodon-binding [IPR004154]", "Anticodon-binding domain [IPR019181]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal [IPR006190]", "ApaG domain [IPR007474]", "Apoptosis-antagonizing transcription factor, C-terminal [IPR012617]", "Arf GTPase activating protein [IPR001164]", "Arginyl tRNA synthetase N-terminal domain [IPR005148]", "Arginyl-tRNA synthetase, catalytic core domain [IPR035684]", "Ariadne domain [IPR045840]", "Armadillo repeat-containing domain [IPR006911]", "Aromatic amino acid beta-eliminating lyase/threonine aldolase [IPR001597]", "Asn/Gln amidotransferase [IPR018027]", "Asparagine synthase [IPR001962]", "Asparagine synthase, N-terminal domain [IPR033738]", "Aspartate/glutamate/uridylate kinase [IPR001048]", "Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain [IPR006131]", "Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding [IPR006132]", "Aspartic peptidase, DDI1-type [IPR019103]", "Aspartyl beta-hydroxylase/Triadin domain [IPR007943]", "Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic [IPR006075]", "Aspartyl/asparaginy/proline hydroxylase [IPR007803]", "Ataxin 2, SM domain [IPR025852]", "Ataxin-10 domain [IPR019156]", "Ataxin-2, C-terminal [IPR009818]", "Aurora-A binding [IPR015128]", "Autophagy-related, C-terminal [IPR015412]", "B(0)AT2, solute-binding domain [IPR042934]", "B-block binding subunit of TFIIIC [IPR007309]", "B-box, C-terminal [IPR003649]", "B-box-type zinc finger [IPR000315]", "B3/B4 tRNA-binding domain [IPR005146]", "B30.2/SPRY domain [IPR001870]", "BAP29/BAP31, transmembrane domain [IPR040463]", "BAR domain [IPR004148]", "BAT2, N-terminal [IPR009738]", "BAZ2A/BAZ2B, bromodomain [IPR037374]", "BDHCT [IPR012532]", "BEACH domain [IPR000409]", "BING4, C-terminal domain [IPR012952]", "BOP1, N-terminal domain [IPR012953]", "BP28, C-terminal domain [IPR012954]", "BRCA1, serine-rich domain [IPR025994]", "BRCT domain [IPR001357]", "BRK domain [IPR006576]", "BRO1 domain [IPR004328]", "BSD domain [IPR005607]", "BTB/Kelch-associated [IPR011705]", "BTB/POZ domain [IPR000210]", "BURAN domain [IPR045354]", "BZW1/2, W2 domain [IPR043510]", "Bacterial Ig-like, group 2 [IPR003343]", "Bacterial surface antigen (D15) [IPR000184]", "Band 4.1 domain [IPR019749]", "Band 4.1, C-terminal [IPR008379]", "Band 7 domain [IPR001107]", "Band 7, C-terminal extension [IPR032435]", "Bap31/Bap29 cytoplasmic coiled-coil domain [IPR041672]", "Beta-Casp domain [IPR022712]", "Beta-adaptin appendage, C-terminal subdomain [IPR015151]", "Beta-amyloid precursor protein C-terminal [IPR019543]", "Beta-catenin-like protein 1, N-terminal [IPR013180]", "Beta-galactosidase jelly roll domain [IPR025300]", "Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019]", "Beta-ketoacyl synthase, C-terminal [IPR014031]", "Beta-ketoacyl synthase, N-terminal [IPR014030]", "Bifunctional delta 1-pyrroline-5-carboxylate synthetase, glutamate-5-kinase domain [IPR041744]", "Biliverdin reductase, catalytic [IPR015249]", "Biotin carboxylase, C-terminal [IPR005482]", "Biotin carboxylase-like, N-terminal domain [IPR005481]", "Biotin carboxylation domain [IPR011764]", "Biotin protein ligase, C-terminal [IPR003142]", "Biotin-protein ligase, N-terminal [IPR019197]", "Biotin/lipoyl attachment [IPR000089]", "Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain [IPR004143]", "Bloom syndrome protein, BDHCT-box associated domain [IPR032439]", "Bloom syndrome protein, N-terminal domain [IPR032437]", "Bms1/Tsr1-type G domain [IPR030387]", "Borealin, N-terminal [IPR018851]", "Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal [IPR018955]", "Brdt, bromodomain, repeat I [IPR043508]", "Brdt, bromodomain, repeat II [IPR043509]", "Brix domain [IPR007109]", "Bromo adjacent homology (BAH) domain [IPR001025]", "Bromodomain [IPR001487]", "Bromodomain adjacent to zinc finger domain protein 1A, bromodomain [IPR037325]", "Brr2, N-terminal helicase PWI domain [IPR041094]", "Butyrophylin-like, SPRY domain [IPR003879]", "C-CAP/cofactor C-like domain [IPR017901]", "C-terminal associated domain of TOPRIM [IPR031660]", "C2 DOCK-type domain [IPR027007]", "C2 domain [IPR000008]", "C4-type zinc-finger of DNA polymerase delta [IPR025687]", "CAAX prenyl protease 1, N-terminal [IPR032456]", "CAP Gly-rich domain [IPR000938]", "CAPN2, penta-EF hand, calcium binding motif [IPR042736]", "CARG-binding factor, N-terminal [IPR012956]", "CARP motif [IPR006599]", "CBS domain [IPR000644]", "CCAAT-binding factor [IPR005612]", "CCD97-like, C-terminal [IPR040233]", "CCR4-NOT transcription complex subunit 1, CAF1-binding domain [IPR032191]", "CCR4-NOT transcription complex subunit 1, HEAT repeat [IPR032194]", "CCR4-NOT transcription complex subunit 1, TTP binding domain [IPR032193]", "CCR4-NOT transcription complex subunit 1, domain 4 [IPR024557]", "CCR4-NOT transcription complex subunit 6 [IPR034966]", "CCR4-Not complex component, Not N-terminal domain [IPR007207]", "CCR4-Not complex component, Not1, C-terminal [IPR007196]", "CD2-associated protein, first SH3 domain [IPR035775]", "CD2-associated protein, second SH3 domain [IPR035776]", "CD2-associated protein, third SH3 domain [IPR035777]", "CD80-like, immunoglobulin C2-set [IPR013162]", "CDC48, N-terminal subdomain [IPR003338]", "CDC48, domain 2 [IPR004201]", "CELF1/2, RNA recognition motif 1 [IPR034196]", "CELF1/2, RNA recognition motif 2 [IPR034198]", "CELF1/2, RNA recognition motif 3 [IPR034199]", "CENP-T/Histone H4, histone fold [IPR035425]", "CEP170, C-terminal [IPR029300]", "CFA20 domain [IPR007714]", "CHD subfamily II, SANT-like domain [IPR009462]", "CHD, C-terminal 2 [IPR012957]", "CHD, N-terminal [IPR012958]", "CHIP, N-terminal tetratricopeptide repeat domain [IPR041312]", "CHIP/LubX , U box domain [IPR045202]", "CHORD domain [IPR007051]", "CID domain [IPR006569]", "CIDE-N domain [IPR003508]", "CLASP N-terminal domain [IPR024395]", "CLU central domain [IPR033646]", "CLU domain [IPR025697]", "CNNM, transmembrane domain [IPR002550]", "COMM domain [IPR017920]", "COP9 signalosome complex subunit 4, helix turn helix domain [IPR041406]", "COP9 signalosome complex subunit 7, helix I [IPR041481]", "COS domain [IPR017903]", "CPH domain [IPR021097]", "CPL domain [IPR012959]", "CPSF2, metallo-hydrolase domain [IPR035639]", "CPSF7, RNA recognition motif [IPR034773]", "CRA domain [IPR013144]", "CRIB domain [IPR000095]", "CRK, C-terminal SH3 domain [IPR035458]", "CRK, N-terminal SH3 domain [IPR035457]", "CS domain [IPR007052]", "CSK-like, SH2 domain [IPR035027]", "CSN8/PSMD8/EIF3K [IPR033464]", "CTLH, C-terminal LisH motif [IPR006595]", "CTLH/CRA C-terminal to LisH motif domain [IPR024964]", "CTP synthase GATase domain [IPR033828]", "CTP synthase, N-terminal [IPR017456]", "CUB domain [IPR000859]", "CYRIA/CYRIB, Rac1 binding domain [IPR009828]", "Cadherin-like [IPR002126]", "Calcineurin-like phosphoesterase domain, ApaH type [IPR004843]", "Calcineurin-like phosphoesterase domain, lpxH-type [IPR024654]", "Calcium/calmodulin-dependent protein kinase II, association-domain [IPR013543]", "Calcyclin-binding Protein, CS domain [IPR037893]", "Calpain subdomain III [IPR033883]", "Calponin homology domain [IPR001715]", "Caprin-1 dimerization domain [IPR041637]", "Carbamoyl-phosphate synthase large subunit, CPSase domain [IPR005483]", "Carbamoyl-phosphate synthase small subunit, GATase1 domain [IPR035686]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain [IPR002474]", "Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain [IPR005479]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain [IPR005480]", "Carbohydrate kinase PfkB [IPR011611]", "Carboxylase, conserved domain [IPR003379]", "Carboxypeptidase D, carboxypeptidase-like domain 2 [IPR034224]", "Carboxypeptidase D, carboxypeptidase-like domain 3 [IPR033848]", "Cation-transporting P-type ATPase, C-terminal [IPR006068]", "Cation-transporting P-type ATPase, N-terminal [IPR004014]", "Cdc23 [IPR007192]", "Cdc37, C-terminal [IPR013873]", "Cdc37, Hsp90 binding [IPR013874]", "Cdc37, N-terminal domain [IPR013855]", "Cell division control protein 73, C-terminal [IPR031336]", "Cellular tumor antigen p53, transactivation domain 2 [IPR040926]", "Centromere protein CENP-B, C-terminal domain [IPR015115]", "Chaperone DnaJ, C-terminal [IPR002939]", "Chitinase II [IPR011583]", "Choline/carnitine acyltransferase domain [IPR039551]", "Choloylglycine hydrolase/NAAA C-terminal [IPR029132]", "Chromatin assembly factor 1 subunit B, C-terminal domain [IPR029129]", "Chromatin target of PRMT1 protein, C-terminal [IPR025715]", "Chromo domain [IPR023780]", "Chromo domain subgroup [IPR017984]", "Chromo shadow domain [IPR008251]", "Chromo/chromo shadow domain [IPR000953]", "Chromosome passenger complex (CPC) protein INCENP N-terminal [IPR022006]", "Circularly permuted (CP)-type guanine nucleotide-binding (G) domain [IPR030378]", "Class I myosin tail homology domain [IPR010926]", "Class I myosin, motor domain [IPR036072]", "Class II PurE [IPR033626]", "Class II aldolase/adducin N-terminal [IPR001303]", "Class VI myosin, motor domain [IPR036114]", "Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain [IPR003164]", "Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain [IPR008152]", "Clathrin, heavy chain, linker, core motif [IPR015348]", "Clathrin/coatomer adaptor, adaptin-like, N-terminal [IPR002553]", "Cleavage and polyadenylation specificity factor 2, C-terminal [IPR025069]", "Cleavage stimulation factor subunit 1, dimerisation domain [IPR032028]", "Cleavage stimulation factor subunit 2, hinge domain [IPR025742]", "Cleavage/polyadenylation specificity factor, A subunit, C-terminal [IPR004871]", "Cleavage/polyadenylation specificity factor, A subunit, N-terminal [IPR018846]", "Clp ATPase, C-terminal [IPR019489]", "Clustered mitochondria protein, N-terminal [IPR028275]", "Cns1/TTC4, wheel domain [IPR044059]", "CoA-binding [IPR003781]", "Coatomer beta subunit, C-terminal [IPR011710]", "Coatomer beta subunit, appendage platform domain [IPR029446]", "Coatomer subunit gamma, C-terminal [IPR032154]", "Coatomer, WD associated region [IPR006692]", "Coatomer, alpha subunit, C-terminal [IPR010714]", "Coatomer, gamma subunit, appendage, Ig-like subdomain [IPR013040]", "Cobalamin (vitamin B12)-binding domain [IPR006158]", "Cobalamin (vitamin B12)-binding module, cap domain [IPR003759]", "Cobalamin adenosyltransferase-like [IPR016030]", "Coilin, N-terminal domain [IPR031722]", "Cold shock domain [IPR011129]", "Cold-shock (CSD) domain [IPR019844]", "Cold-shock protein, DNA-binding [IPR002059]", "Complex 1 LYR protein domain [IPR008011]", "Condensin complex subunit 1, C-terminal [IPR032682]", "Condensin complex subunit 1, N-terminal [IPR024324]", "Cop9 signalosome subunit 5 C-terminal domain [IPR040961]", "Copine, C-terminal [IPR010734]", "Copine, C2B domain [IPR037768]", "Core histone macro-H2A, macro domain [IPR035796]", "Cortactin, SH3 domain [IPR035716]", "Creatinase, N-terminal [IPR000587]", "Cullin homology domain [IPR016158]", "Cullin protein, neddylation domain [IPR019559]", "Cullin, N-terminal [IPR001373]", "Cupin-like domain 8 [IPR041667]", "Cwf19-like protein, C-terminal domain-2 [IPR006767]", "Cwf19-like, C-terminal domain-1 [IPR006768]", "Cyclic nucleotide-binding domain [IPR000595]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain [IPR002130]", "Cystatin domain [IPR000010]", "Cysteine-rich flanking region, C-terminal [IPR000483]", "Cystine knot, C-terminal [IPR006207]", "Cytochrome C oxidase subunit II, transmembrane domain [IPR011759]", "Cytochrome b5-like heme/steroid binding domain [IPR001199]", "Cytochrome c oxidase assembly factor 3, mitochondrial, coiled-coil domain [IPR018628]", "Cytochrome c oxidase subunit 2, C-terminal [IPR034210]", "Cytochrome c oxidase subunit II-like C-terminal [IPR002429]", "Cytochrome c oxidase, subunit II [IPR014222]", "Cytoplasmic activation/proliferation-associated protein-1 C term [IPR022070]", "Cytoskeleton-associated protein 2, C-terminal [IPR029197]", "D-3-phosphoglycerate dehydrogenase, ASB domain [IPR045626]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain [IPR006140]", "D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain [IPR006139]", "DALR anticodon binding [IPR008909]", "DAZ-associated protein 1, RNA recognition motif 1 [IPR034134]", "DAZ-associated protein 1, RNA recognition motif 2 [IPR034131]", "DBC1/CARP1 catalytically inactive NUDIX hydrolase domain [IPR025954]", "DBINO domain [IPR020838]", "DBP10, C-terminal [IPR012541]", "DDE superfamily endonuclease domain [IPR004875]", "DDHD domain [IPR004177]", "DDT domain [IPR018501]", "DDX18/Has1, DEAD-box helicase domain [IPR044773]", "DDX41, DEAD-box helicase domain [IPR044113]", "DDX47/Rrp3, DEAD-box helicase domain [IPR044765]", "DDX52/Rok1, DEAD-box helicase domain [IPR044764]", "DEAD box protein 17, ATP-binding domain [IPR046330]", "DEAD/DEAH box helicase domain [IPR011545]", "DEAD2 [IPR010614]", "DEK, C-terminal [IPR014876]", "DEUBAD domain [IPR044867]", "DExH-box ATP-dependent RNA helicase, R3H domain [IPR034083]", "DFDF domain [IPR025762]", "DHHA1 domain [IPR003156]", "DHX15, DEXH-box helicase domain [IPR044756]", "DHX8/ Prp22, DEXH-box helicase domain [IPR044762]", "DHX9, DEXH-box helicase domain [IPR044447]", "DHX9, first double-stranded RNA binding domain [IPR044445]", "DHX9, second double-stranded RNA binding domain [IPR044446]", "DJ-1/PfpI [IPR002818]", "DMAP1-binding domain [IPR010506]", "DNA (cytosine-5)-methyltransferase 1, replication foci domain [IPR022702]", "DNA binding HTH domain, Psq-type [IPR007889]", "DNA damage inducible protein 1 ubiquitin-like domain [IPR033882]", "DNA fragmentation factor 45kDa, middle domain [IPR015121]", "DNA ligase 3, BRCT domain [IPR031916]", "DNA ligase, ATP-dependent, C-terminal [IPR012309]", "DNA ligase, ATP-dependent, N-terminal [IPR012308]", "DNA ligase, ATP-dependent, central [IPR012310]", "DNA mismatch repair protein MutS, C-terminal [IPR000432]", "DNA mismatch repair protein MutS, clamp [IPR007861]", "DNA mismatch repair protein MutS, connector domain [IPR007860]", "DNA mismatch repair protein MutS, core [IPR007696]", "DNA mismatch repair protein MutS-like, N-terminal [IPR007695]", "DNA polymerase epsilon, catalytic subunit A, C-terminal [IPR013697]", "DNA replication complex GINS protein SLD5, C-terminal [IPR031633]", "DNA replication factor RFC1, C-terminal [IPR013725]", "DNA topoisomerase 2, TOPRIM domain [IPR034157]", "DNA topoisomerase I, DNA binding, eukaryotic-type [IPR008336]", "DNA topoisomerase I, catalytic core, eukaryotic-type [IPR013500]", "DNA topoisomerase I, eukaryotic-type [IPR013499]", "DNA topoisomerase, type IIA, domain A [IPR002205]", "DNA topoisomerase, type IIA, subunit B, domain 2 [IPR013506]", "DNA-dependent protein kinase catalytic subunit, CC3 [IPR012582]", "DNA-dependent protein kinase catalytic subunit, CC5 [IPR045581]", "DNA-dependent protein kinase catalytic subunit, catalytic domain [IPR037706]", "DNA-directed DNA polymerase, family B, exonuclease domain [IPR006133]", "DNA-directed DNA polymerase, family B, multifunctional domain [IPR006134]", "DNA-directed RNA polymerase I subunit RPA2, domain 4 [IPR009674]", "DNA-directed RNA polymerase III subunit RPC1, C-terminal [IPR035698]", "DNA-directed RNA polymerase III subunit RPC1, N-terminal [IPR035697]", "DNA-directed RNA polymerase, N-terminal [IPR029262]", "DNA-directed RNA polymerase, RpoA/D/Rpb3-type [IPR011263]", "DNA-directed RNA polymerase, insert domain [IPR011262]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120]", "DNA-repair protein Xrcc1, N-terminal [IPR002706]", "DNA2/NAM7 helicase, helicase domain [IPR041677]", "DNA2/NAM7 helicase-like, C-terminal [IPR041679]", "DOCKER domain [IPR027357]", "DPF1-3, N-terminal domain [IPR025750]", "DSBA-like thioredoxin domain [IPR001853]", "DTHCT [IPR012542]", "DWNN domain [IPR014891]", "DZF domain [IPR006561]", "Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791]", "Dbl homology (DH) domain [IPR000219]", "Death domain [IPR000488]", "Dedicator of cytokinesis C, C2 domain [IPR037808]", "Dedicator of cytokinesis C/D, N-terminal [IPR021816]", "Dehydrogenase, E1 component [IPR001017]", "Deoxynucleoside kinase domain [IPR031314]", "Desmoplakin, SH3 domain [IPR041615]", "Desmoplakin, spectrin-like domain [IPR041573]", "Deubiquitinating enzyme MINDY-3/4, conserved domain [IPR025257]", "Diacylglycerol kinase, catalytic domain [IPR001206]", "Diaphanous autoregulatory (DAD) domain [IPR014767]", "Dihydrofolate reductase domain [IPR001796]", "Dilute domain [IPR002710]", "Dipeptidyl peptidase 8 /9 ,N-terminal [IPR045785]", "Dipeptidylpeptidase IV, N-terminal domain [IPR002469]", "Dis3-like cold-shock domain 2 [IPR041505]", "Disintegrin domain [IPR001762]", "Disulphide isomerase [IPR005788]", "DnaJ domain [IPR001623]", "DnaJ-like protein C11, C-terminal [IPR024586]", "Domain of unknown function DUF1087 [IPR009463]", "Domain of unknown function DUF1115 [IPR010541]", "Domain of unknown function DUF1605 [IPR011709]", "Domain of unknown function DUF1731 [IPR013549]", "Domain of unknown function DUF1747 [IPR013719]", "Domain of unknown function DUF1899 [IPR015048]", "Domain of unknown function DUF3350 [IPR021785]", "Domain of unknown function DUF3385, target of rapamycin protein [IPR024585]", "Domain of unknown function DUF3456 [IPR021852]", "Domain of unknown function DUF3480 [IPR022557]", "Domain of unknown function DUF3517 [IPR021905]", "Domain of unknown function DUF382 [IPR007180]", "Domain of unknown function DUF4149 [IPR025423]", "Domain of unknown function DUF4217 [IPR025313]", "Domain of unknown function DUF4749 [IPR031847]", "Domain of unknown function DUF5600 [IPR040990]", "Domain of unknown function DUF5921 [IPR045803]", "Double-stranded RNA-binding domain [IPR014720]", "Down-regulated-in-metastasis protein [IPR011430]", "Drebrin-like protein, SH3 domain [IPR035717]", "Drought induced 19 protein type, zinc-binding domain [IPR008598]", "Dual specificity phosphatase, catalytic domain [IPR000340]", "Dual specificity protein phosphatase domain [IPR020422]", "Dullard phosphatase domain, eukaryotic [IPR011948]", "Dynamin GTPase effector [IPR003130]", "Dynamin stalk domain [IPR000375]", "Dynamin, GTPase domain [IPR001401]", "Dynamin, N-terminal [IPR045063]", "Dynamin-like GTPase OPA1, C-terminal [IPR045817]", "Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]", "Dynein associated protein [IPR022157]", "Dynein heavy chain AAA lid domain [IPR041658]", "Dynein heavy chain region D6 P-loop domain [IPR004273]", "Dynein heavy chain, AAA 5 extension domain [IPR041466]", "Dynein heavy chain, AAA module D4 [IPR024317]", "Dynein heavy chain, ATP-binding dynein motor region [IPR035706]", "Dynein heavy chain, C-terminal domain [IPR041228]", "Dynein heavy chain, coiled coil stalk [IPR024743]", "Dynein heavy chain, hydrolytic ATP-binding dynein motor region [IPR035699]", "Dynein heavy chain, linker [IPR013602]", "Dynein heavy chain, tail [IPR013594]", "Dyskerin-like [IPR012960]", "E2 binding [IPR014929]", "E3 ligase, CCCH-type zinc finger [IPR041367]", "E3 ubiquitin ligase EDD, ubiquitin-associated domain [IPR024725]", "E3 ubiquitin ligase UBR4, C-terminal [IPR025704]", "E3 ubiquitin ligase, domain of unknown function DUF908 [IPR010309]", "E3 ubiquitin ligase, domain of unknown function DUF913 [IPR010314]", "E3 ubiquitin-protein ligase RNF114, RING finger, HC subclass [IPR042716]", "E3 ubiquitin-protein ligase UBR4, N-terminal [IPR045841]", "EB1, C-terminal [IPR004953]", "EBP50, C-terminal [IPR015098]", "ECSIT, C-terminal domain [IPR029342]", "EF hand associated, type-1 [IPR013566]", "EF hand associated, type-2 [IPR013567]", "EF-hand domain [IPR002048]", "EF-hand domain, type 1 [IPR015153]", "EF-hand domain, type 2 [IPR015154]", "EF-hand, Ca insensitive [IPR014837]", "EFG, domain V [IPR035649]", "EGF-like calcium-binding domain [IPR001881]", "EGF-like domain [IPR000742]", "EGF-like domain, extracellular [IPR013111]", "EH domain [IPR000261]", "EH domain-containing protein, N-terminal [IPR031692]", "EIF2AK2, first double-stranded RNA binding domain [IPR044452]", "EIF2AK2, second double-stranded RNA binding domain [IPR044453]", "ELM2 domain [IPR000949]", "ELMO domain [IPR006816]", "ENTH domain [IPR013809]", "ER membrane protein complex subunit 1, C-terminal [IPR011678]", "ER membrane protein complex subunit 7, beta-sandwich domain [IPR019008]", "ERAP1-like C-terminal domain [IPR024571]", "ERCC3/RAD25/XPB helicase, C-terminal domain [IPR032438]", "ERM family, FERM domain C-lobe [IPR041789]", "ERV/ALR sulfhydryl oxidase domain [IPR017905]", "ERdj5, C-terminal thioredoxin domain [IPR035674]", "ERdj5, first thioredoxin domain [IPR035673]", "ERp29, N-terminal [IPR012883]", "EWS, RNA recognition motif [IPR034869]", "EXPERA domain [IPR033118]", "Electron transfer flavoprotein, alpha subunit, C-terminal [IPR014731]", "Electron transfer flavoprotein, alpha subunit, N-terminal [IPR033947]", "Electron transfer flavoprotein, alpha/beta-subunit, N-terminal [IPR014730]", "Electron transfer flavoprotein, beta subunit, N-terminal [IPR033948]", "Elongation Factor G, domain II [IPR041095]", "Elongation factor 1 beta central acidic region, eukaryote [IPR018940]", "Elongation factor 1B gamma, C-terminal [IPR001662]", "Elongation factor EFG, domain V-like [IPR000640]", "Elongation factor G, domain III [IPR009022]", "Elongation factor Tu (EF-Tu), GTP-binding domain [IPR041709]", "Elongation factor Tu, domain 2 [IPR033720]", "Elp3/MiaB/NifB [IPR006638]", "Emerin, LEM domain [IPR034989]", "Endonuclease/exonuclease/phosphatase [IPR005135]", "Endophilin-A, SH3 domain [IPR035824]", "Endophilin-B1, BAR domain [IPR035695]", "Endoplasmic reticulum resident protein 29, C-terminal [IPR011679]", "Endoplasmic reticulum resident protein 44, TRX-like domain b [IPR041870]", "Endoplasmic reticulum resident protein 44, TRX-like domain b' [IPR041862]", "Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]", "Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]", "Enhancer of mRNA-decapping protein 4, WD40 repeat region [IPR032401]", "Enolase, C-terminal TIM barrel domain [IPR020810]", "Enolase, N-terminal [IPR020811]", "Enoyl-CoA hydratase/isomerase domain [IPR045004]", "Ephrin receptor ligand binding domain [IPR001090]", "Ephrin receptor, transmembrane domain [IPR027936]", "Ephrin type-A receptor 7, ligand binding domain [IPR034283]", "Era-type guanine nucleotide-binding (G) domain [IPR030388]", "Eukaryotic Ribosomal Protein L27, KOW domain [IPR041991]", "Eukaryotic glycogen debranching enzyme, N-terminal domain [IPR029436]", "Eukaryotic translation initiation factor 3 subunit E, N-terminal [IPR019010]", "Eukaryotic translation initiation factor 3 subunit G, N-terminal [IPR024675]", "Exocyst complex component EXOC2/Sec5, N-terminal domain [IPR039481]", "Exonuclease 1-like, PIN-like domain [IPR044752]", "Exonuclease, RNase T/DNA polymerase III [IPR013520]", "Exonuclease-1, H3TH domain [IPR037315]", "Exoribonuclease, phosphorolytic domain 1 [IPR001247]", "Exoribonuclease, phosphorolytic domain 2 [IPR015847]", "Exosome complex component CSL4, C-terminal [IPR019495]", "Exosome complex component, N-terminal domain [IPR025721]", "Exosome complex exonuclease RRP44, S1 domain [IPR033770]", "Exosome-associated factor Rrp6, N-terminal [IPR012588]", "Exportin-1, C-terminal [IPR014877]", "Exportin-1/Importin-beta-like [IPR013598]", "Exportin-2, C-terminal [IPR005043]", "Exportin-2, central domain [IPR013713]", "Exportin-5, C-terminal domain [IPR045478]", "Extended PHD (ePHD) domain [IPR034732]", "Extended synaptotagmin, C-terminal C2 domain [IPR037752]", "Extended synaptotagmin, C2A domain [IPR037733]", "Extended synaptotagmin, C2B domain [IPR037749]", "F-BAR domain [IPR031160]", "F-box domain [IPR001810]", "FACT complex subunit POB3-like, N-terminal PH domain [IPR035417]", "FACT complex subunit Spt16 domain [IPR013953]", "FACT complex subunit Spt16, N-terminal lobe domain [IPR029148]", "FACT complex subunit Spt16, peptidase M24-like domain [IPR033825]", "FAD dependent oxidoreductase [IPR006076]", "FAD dependent oxidoreductase, central domain [IPR032503]", "FAD linked oxidase, N-terminal [IPR006094]", "FAD-binding domain, PCMH-type [IPR016166]", "FAD-binding domain, ferredoxin reductase-type [IPR017927]", "FAD-dependent oxidoreductase 2, FAD binding domain [IPR003953]", "FAD-linked oxidase, C-terminal [IPR004113]", "FAD/NAD(P)-binding domain [IPR023753]", "FAF1, UBA-like domain [IPR044541]", "FANCI helical domain 1 [IPR029310]", "FANCI helical domain 2 [IPR029312]", "FANCI solenoid 1 cap [IPR029305]", "FANCI solenoid 1 domain [IPR029308]", "FANCI solenoid 2 domain [IPR029315]", "FANCI solenoid 3 domain [IPR029313]", "FANCI solenoid 4 domain [IPR029314]", "FAS-associated factor 1-like, UBX domain [IPR033043]", "FAST kinase leucine-rich [IPR010622]", "FAST kinase-like protein, subdomain 2 [IPR013579]", "FATC domain [IPR003152]", "FCH domain [IPR001060]", "FCP1 homology domain [IPR004274]", "FDF domain [IPR019050]", "FERM adjacent (FA) [IPR014847]", "FERM central domain [IPR019748]", "FERM domain [IPR000299]", "FERM, C-terminal PH-like domain [IPR018980]", "FERM, N-terminal [IPR018979]", "FF domain [IPR002713]", "FFD box [IPR025761]", "FGFR1 oncogene partner (FOP), N-terminal dimerisation domain [IPR018993]", "FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]", "FKBP12-rapamycin binding domain [IPR009076]", "FKBP3, basic tilted helix bundle domain [IPR041200]", "FY-rich, C-terminal [IPR003889]", "FY-rich, N-terminal [IPR003888]", "FYVE zinc finger [IPR000306]", "Far upstream element-binding protein, C-terminal [IPR015096]", "Fascin domain [IPR022768]", "Fatty acid desaturase domain [IPR005804]", "Fatty acyl-CoA reductase, C-terminal [IPR033640]", "Fatty acyl-coenzyme A reductase, NAD-binding domain [IPR013120]", "Fcf2 pre-rRNA processing, C-terminal [IPR014810]", "Ferric reductase transmembrane component-like domain [IPR013130]", "Ferrochelatase, C-terminal [IPR033644]", "Ferrochelatase, N-terminal [IPR033659]", "Fibronectin type II domain [IPR000562]", "Fibronectin type III [IPR003961]", "First polo-box domain [IPR033701]", "Flavodoxin-like [IPR001094]", "Flavodoxin/nitric oxide synthase [IPR008254]", "Flavoprotein pyridine nucleotide cytochrome reductase [IPR001709]", "Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain [IPR008333]", "Follistatin-like, N-terminal [IPR003645]", "Fork head domain [IPR001766]", "Forkhead-associated (FHA) domain [IPR000253]", "Formin, FH2 domain [IPR015425]", "Formin, FH3 domain [IPR010472]", "Formin, GTPase-binding domain [IPR010473]", "Formyl transferase, N-terminal [IPR002376]", "Fragile X-related 1 protein, C-terminal core [IPR022034]", "Fragile X-related 1 protein, C-terminal region 1 [IPR032172]", "Fragile X-related 1 protein, C-terminal region 3 [IPR032177]", "Fragile X-related mental retardation protein, C-terminal region 2 [IPR032196]", "Fumarase C, C-terminal [IPR018951]", "Fumarate lyase, N-terminal [IPR022761]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal [IPR015939]", "Fumarylacetoacetase, N-terminal [IPR015377]", "Fumarylacetoacetase-like, C-terminal [IPR011234]", "Fxr1, tudor domain [IPR041560]", "Fzo/mitofusin HR2 domain [IPR006884]", "G-patch domain [IPR000467]", "G-protein, beta subunit [IPR001632]", "G3BP1, RNA recognition motif [IPR034374]", "G3BP2, RNA recognition motif [IPR034376]", "GAD domain [IPR029351]", "GAR domain [IPR003108]", "GAT domain [IPR004152]", "GB1/RHD3-type guanine nucleotide-binding (G) domain [IPR030386]", "GCC2, Rab binding domain [IPR032023]", "GHMP kinase N-terminal domain [IPR006204]", "GHMP kinase, C-terminal domain [IPR013750]", "GINS complex protein Sld5, alpha-helical domain [IPR038749]", "GINS subunit, domain A [IPR021151]", "GMP phosphodiesterase, delta subunit [IPR008015]", "GMP synthase, C-terminal [IPR001674]", "GMP synthase, glutamine amidotransferase [IPR004739]", "GMP synthetase ATP pyrophosphatase domain [IPR025777]", "GNAT domain [IPR000182]", "GOLD domain [IPR009038]", "GPAT/DHAPAT, acyltransferase domain [IPR041728]", "GPR domain [IPR000965]", "GRAM domain [IPR004182]", "GRASP-type PDZ domain [IPR024958]", "GRB2, C-terminal SH3 domain [IPR035643]", "GRB2, N-terminal SH3 domain [IPR035641]", "GRIP domain [IPR000237]", "GRSF-1, RNA recognition motif 1 [IPR034425]", "GRSF-1, RNA recognition motif 2 [IPR034424]", "GRSF-1, RNA recognition motif 3 [IPR034426]", "GTP binding domain [IPR006073]", "GTP binding protein 1-like, GTP-binding domain [IPR035531]", "GTP binding protein, second domain [IPR031662]", "GTP-binding protein TrmE, N-terminal [IPR018948]", "GTP1/OBG domain [IPR006169]", "GTPase effector domain [IPR020850]", "GUCT [IPR012562]", "GYF domain [IPR003169]", "Galactokinase, N-terminal domain [IPR019539]", "Galactose mutarotase, N-terminal barrel [IPR031727]", "Gamma tubulin complex component protein, N-terminal [IPR041470]", "Gamma tubulin complex component, C-terminal [IPR040457]", "Gamma-adaptin ear (GAE) domain [IPR008153]", "Gamma-glutamyl cyclotransferase-like [IPR013024]", "Gelsolin-like domain [IPR007123]", "Gfo/Idh/MocA-like oxidoreductase, N-terminal [IPR000683]", "GlmS/AgaS, SIS domain 1 [IPR035466]", "GlmS/FrlB, SIS domain 2 [IPR035490]", "Glucosamine/galactosamine-6-phosphate isomerase [IPR006148]", "Glucose-6-phosphate dehydrogenase, C-terminal [IPR022675]", "Glucose-6-phosphate dehydrogenase, NAD-binding [IPR022674]", "Glucosidase 2 subunit beta-like [IPR036607]", "Glucosidase II beta subunit, N-terminal [IPR028146]", "Glucosyltransferase 24, catalytic domain [IPR040497]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal [IPR006096]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain [IPR006097]", "Glutaminase, EF-hand domain [IPR041541]", "Glutamine amidotransferase [IPR017926]", "Glutamine amidotransferase type 2 domain [IPR017932]", "Glutamine-Leucine-Glutamine, QLQ [IPR014978]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2 [IPR007638]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal [IPR007639]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain [IPR020059]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain [IPR020058]", "Glutaredoxin [IPR002109]", "Glutaredoxin, PICOT-like [IPR033658]", "Glutathione S-transferase, C-terminal [IPR004046]", "Glutathione S-transferase, C-terminal-like [IPR010987]", "Glutathione S-transferase, N-terminal [IPR004045]", "Glutathione S-transferases, class Zeta , C-terminal [IPR034330]", "Glutathione S-transferases, class Zeta , N-terminal [IPR034333]", "Glutathione synthase, substrate-binding domain [IPR004887]", "Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain [IPR020828]", "Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain [IPR020829]", "Glycerol-3-phosphate acyltransferase-like, C-terminal domain [IPR045520]", "Glycine cleavage T-protein, C-terminal barrel domain [IPR013977]", "Glycogen debranching enzyme, C-terminal [IPR032790]", "Glycogen debranching enzyme, central domain [IPR032788]", "Glycogen debranching enzyme, glucanotransferase domain [IPR032792]", "Glycogen synthase kinase 3, catalytic domain [IPR039192]", "Glycoside hydrolase 35, catalytic domain [IPR031330]", "Glycoside hydrolase family 18, catalytic domain [IPR001223]", "Glycoside hydrolase family 2, catalytic domain [IPR006103]", "Glycoside hydrolase family 20, catalytic domain [IPR015883]", "Glycoside hydrolase family 31, N-terminal domain [IPR025887]", "Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich [IPR006102]", "Glycosyl hydrolase family 30, TIM-barrel domain [IPR033453]", "Glycosyl hydrolase family 30, beta sandwich domain [IPR033452]", "Glycosyl hydrolase family 63, C-terminal [IPR031335]", "Glycosyl hydrolase family 63, N-terminal [IPR031631]", "Glycosyl hydrolase, family 13, catalytic domain [IPR006047]", "Glycosyl hydrolases family 2, sugar binding domain [IPR006104]", "Glycosyl transferase CAP10 domain [IPR006598]", "Glycosyltransferase 2-like [IPR001173]", "Glycyl-tRNA synthetase-like core domain [IPR033731]", "Glyoxalase domain-containing protein 4, C-terminal [IPR043194]", "Glyoxalase/fosfomycin resistance/dioxygenase domain [IPR004360]", "Guanine nucleotide exchange factor, N-terminal [IPR032691]", "Guanine nucleotide-binding protein-like 3, N-terminal domain [IPR014813]", "Guanylate kinase-like domain [IPR008144]", "Guanylate kinase/L-type calcium channel beta subunit [IPR008145]", "Guanylate-binding protein, N-terminal [IPR015894]", "Guanylate-binding protein/Atlastin, C-terminal [IPR003191]", "HBS1-like protein, N-terminal [IPR015033]", "HD domain [IPR006674]", "HD/PDEase domain [IPR003607]", "HDGF-related, PWWP domain [IPR035496]", "HECT domain [IPR000569]", "HELLS, N-terminal [IPR044753]", "HELP [IPR005108]", "HERC2, APC10 domain [IPR037976]", "HERC2, zinc finger, ZZ-type [IPR041987]", "HHH domain 9 [IPR041692]", "HIRAN domain [IPR014905]", "HIT-like domain [IPR011146]", "HR1 rho-binding domain [IPR011072]", "HRDC domain [IPR002121]", "HSPA4, nucleotide-binding domain [IPR042052]", "HSPA4L, nucleotide-binding domain [IPR042708]", "HSPH1, nucleotide-binding domain [IPR042053]", "HTH CenpB-type DNA-binding domain [IPR006600]", "HTTM [IPR011020]", "HUWE1, UBA domain [IPR041918]", "Heat shock 70kDa protein 14, nucleotide-binding domain [IPR042049]", "Heat shock chaperonin-binding [IPR006636]", "Heat shock protein DnaJ, cysteine-rich domain [IPR001305]", "Heat shock protein Hsp90, N-terminal [IPR020575]", "Heat shock protein beta-1, ACD domain [IPR037876]", "Helical and beta-bridge domain [IPR010643]", "Helicase XPB/Ssl2, N-terminal domain [IPR032830]", "Helicase domain [IPR007807]", "Helicase superfamily 1/2, ATP-binding domain [IPR014001]", "Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type [IPR014013]", "Helicase, C-terminal [IPR001650]", "Helicase-associated domain [IPR007502]", "Helicase-like, DEXD box c2 type [IPR006554]", "Helicase/SANT-associated domain [IPR014012]", "Helicase/UvrB, N-terminal [IPR006935]", "Helix-hairpin-helix DNA-binding motif, class 1 [IPR003583]", "Helix-turn-helix DNA-binding domain of Spt6 [IPR028088]", "Hemimethylated DNA-binding domain [IPR011722]", "Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 1 [IPR034544]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 2 [IPR034548]", "Heterogeneous nuclear ribonucleoprotein R, RNA recognition motif 2 [IPR034411]", "Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]", "Hexokinase, C-terminal [IPR022673]", "Hexokinase, N-terminal [IPR022672]", "High mobility group box domain 5 [IPR029215]", "High mobility group box domain [IPR009071]", "Histidine kinase domain [IPR005467]", "Histidine kinase/HSP90-like ATPase [IPR003594]", "Histone H2A, C-terminal domain [IPR032454]", "Histone H2A/H2B/H3 [IPR007125]", "Histone acetyl transferase HAT1 N-terminal [IPR019467]", "Histone deacetylase domain [IPR023801]", "Histone deacetylase interacting domain [IPR013194]", "Histone-arginine methyltransferase CARM1, N-terminal [IPR020989]", "Histone-binding protein RBBP4, N-terminal [IPR022052]", "HnRNP M, nuclear localisation signal [IPR024666]", "Homeobox domain [IPR001356]", "Homeobox domain, metazoa [IPR020479]", "Homocysteine-binding domain [IPR003726]", "Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120]", "HuR, RNA recognition motif 2 [IPR034996]", "Hyaluronan/mRNA-binding protein [IPR006861]", "Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain [IPR013746]", "Hydroxymethylglutaryl-coenzyme A synthase, N-terminal [IPR013528]", "I/LWEQ domain [IPR002558]", "IBR domain [IPR002867]", "IF2a, S1-like domain [IPR044126]", "IGF2BP1, RNA recognition motif 1 [IPR034837]", "IGF2BP1, RNA recognition motif 2 [IPR034842]", "IGF2BP3, RNA recognition motif 2 [IPR034844]", "IMD/I-BAR domain [IPR013606]", "IMP dehydrogenase/GMP reductase [IPR001093]", "IPT domain [IPR002909]", "IRG-type guanine nucleotide-binding (G) domain [IPR030385]", "IRS-type PTB domain [IPR002404]", "IRSp53, SH3 domain [IPR035594]", "ISWI, HAND domain [IPR015194]", "Ima1, N-terminal domain [IPR018617]", "Immunoglobulin C1-set [IPR003597]", "Immunoglobulin I-set [IPR013098]", "Immunoglobulin V-set domain [IPR013106]", "Immunoglobulin subtype 2 [IPR003598]", "Immunoglobulin subtype [IPR003599]", "Immunoglobulin-like domain [IPR007110]", "Importin-alpha, importin-beta-binding domain [IPR002652]", "Importin-beta, N-terminal domain [IPR001494]", "Initiation factor eIF-4 gamma, MA3 [IPR003891]", "Inner centromere protein, ARK-binding domain [IPR005635]", "Integrator complex subunit 11, MBL-fold [IPR041897]", "Integrator complex subunit 14, C-terminal [IPR045814]", "Integrator complex subunit 3, N-terminal [IPR019333]", "Integrin beta N-terminal [IPR033760]", "Integrin beta subunit, VWA domain [IPR002369]", "Integrin beta subunit, cytoplasmic domain [IPR014836]", "Integrin beta subunit, tail [IPR012896]", "Integrin beta, epidermal growth factor-like domain 1 [IPR040622]", "Integrin-linked protein kinase, pseudokinase domain [IPR035692]", "Intermediate filament head, DNA-binding domain [IPR006821]", "Intermediate filament, rod domain [IPR039008]", "Intracellular hyaluronan-binding protein 4, N-terminal domain [IPR032381]", "Ion transporter-like, CBS domain [IPR044751]", "Iron sulphur domain-containing, mitoNEET, N-terminal [IPR019610]", "Iron-binding zinc finger, CDGSH type [IPR018967]", "Isochorismatase-like [IPR000868]", "Isoleucyl tRNA synthetase type 1, anticodon-binding domain [IPR033708]", "Isoleucyl tRNA synthetase type 2, anticodon-binding domain [IPR033709]", "Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain [IPR044861]", "Isopropylmalate dehydrogenase-like domain [IPR024084]", "JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]", "JNK-interacting protein, leucine zipper II [IPR032486]", "JNK/Rab-associated protein-1, N-terminal [IPR019143]", "JmjC domain [IPR003347]", "Jumonji, helical domain [IPR041070]", "K Homology domain [IPR004087]", "K Homology domain, type 1 [IPR004088]", "K Homology domain, type 2 [IPR004044]", "KASH domain [IPR012315]", "KHDRBS, Qua1 domain [IPR032571]", "KMT2A, PHD domain 1 [IPR042023]", "KMT2A, PHD domain 2 [IPR042025]", "KMT2A, PHD domain 3 [IPR044133]", "KMT2A, ePHD domain [IPR041958]", "KOW [IPR005824]", "Kinase associated domain 1 (KA1) [IPR001772]", "Kindlin-2, N-terminal [IPR040790]", "Kindlin/fermitin, PH domain [IPR037837]", "Kinesin motor domain [IPR001752]", "Kinesin-associated [IPR032405]", "Kinesin-associated microtubule-binding domain [IPR025901]", "Kinesin-like [IPR022164]", "Kinesin-like protein Kif23, Arf6-interacting domain [IPR032384]", "Kri1-like, C-terminal [IPR024626]", "Krr1, KH1 domain [IPR041174]", "Ku, C-terminal [IPR014893]", "Ku70/Ku80 C-terminal arm [IPR005160]", "Ku70/Ku80 beta-barrel domain [IPR006164]", "Ku70/Ku80, N-terminal alpha/beta [IPR005161]", "L27 domain [IPR004172]", "L27 domain, C-terminal [IPR014775]", "LAIKA domain [IPR045353]", "LARP4, RNA recognition motif [IPR034903]", "LARP5, RNA recognition motif [IPR034900]", "LARP7, RNA recognition motif 1 [IPR034887]", "LARP7, RNA recognition motif 2 [IPR034910]", "LEM domain [IPR003887]", "LEM-like domain [IPR013146]", "LETM1, ribosome-binding domain [IPR033122]", "LETM1-like [IPR011685]", "LIS1 homology motif [IPR006594]", "LSM domain, eukaryotic/archaea-type [IPR001163]", "LSM-interacting domain [IPR008669]", "La protein, xRRM domain [IPR014886]", "La-related protein 7, La domain [IPR034946]", "La-type HTH domain [IPR006630]", "Lactate/malate dehydrogenase, C-terminal [IPR022383]", "Lactate/malate dehydrogenase, N-terminal [IPR001236]", "Lamin tail domain [IPR001322]", "Lamin-B receptor of TUDOR domain [IPR019023]", "Lamina-associated polypeptide 2 alpha, C-terminal [IPR021623]", "Laminin G domain [IPR001791]", "Large proline-rich protein BAG6 [IPR021925]", "Lasp1, SH3 domain [IPR035630]", "Legume-like lectin [IPR005052]", "Lens epithelium-derived growth factor, integrase-binding domain [IPR021567]", "Lethal giant larvae homologue 2 [IPR013577]", "Leucine zipper, homeobox-associated [IPR003106]", "Leucine-rich repeat N-terminal domain [IPR000372]", "Linker histone H1/H5, domain H15 [IPR005818]", "Listerin, zinc finger, RING-type [IPR039804]", "Lon, substrate-binding domain [IPR003111]", "Longin domain [IPR010908]", "Lsm14-like, N-terminal [IPR025609]", "Lsm16, N-terminal [IPR034107]", "LsmAD domain [IPR009604]", "Lysine-tRNA ligase, class II, N-terminal [IPR044136]", "Lysophosphatidylcholine acyltransferase LPCAT1-like [IPR045252]", "Lysyl-tRNA synthetase, class II, C-terminal [IPR018149]", "M60-like domain, N-terminal [IPR035423]", "MAGE homology domain [IPR002190]", "MAN1, RNA recognition motif [IPR034394]", "MATH/TRAF domain [IPR002083]", "MCM N-terminal domain [IPR027925]", "MCM OB domain [IPR033762]", "MCM domain [IPR001208]", "MCM, AAA-lid domain [IPR041562]", "MD-2-related lipid-recognition domain [IPR003172]", "MDM2-binding protein, N-terminal domain [IPR029421]", "MDM2-binding protein, central domain [IPR029420]", "MDN2-binding protein, C-terminal domain [IPR029418]", "MEF-2, RNA recognition motif 1 [IPR034630]", "MEF-2, RNA recognition motif 3 [IPR034631]", "MENTAL domain [IPR019498]", "MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]", "MHC class I, alpha chain, C-terminal [IPR010579]", "MHC class I-like antigen recognition-like [IPR011161]", "MIF4G-like, type 1 [IPR015172]", "MIF4G-like, type 2 [IPR015174]", "MIF4G-like, type 3 [IPR003890]", "MIRO domain [IPR020860]", "MIT domain [IPR007330]", "MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding [IPR021043]", "MMS19, C-terminal [IPR024687]", "MMS19, N-terminal [IPR029240]", "MOSC, N-terminal beta barrel [IPR005303]", "MPN domain [IPR037518]", "MPP2, SH3 domain [IPR035602]", "MPP6, SH3 domain [IPR035603]", "MRG domain [IPR026541]", "MRH domain [IPR044865]", "MRPL44, double-stranded RNA binding domain [IPR044444]", "MTMR6, PH-GRAM domain [IPR035998]", "Macro domain [IPR002589]", "Mad3/Bub1 homology region 1 [IPR013212]", "Major facilitator superfamily domain [IPR020846]", "Major sperm protein (MSP) domain [IPR000535]", "Malectin domain [IPR021720]", "Malic enzyme, N-terminal domain [IPR012301]", "Malic enzyme, NAD-binding [IPR012302]", "Man1/Src1, C-terminal [IPR018996]", "Manganese/iron superoxide dismutase, C-terminal [IPR019832]", "Manganese/iron superoxide dismutase, N-terminal [IPR019831]", "MaoC-like dehydratase domain [IPR002539]", "Marvel domain [IPR008253]", "Matrin-3, RNA recognition motif 1 [IPR034928]", "Matrin-3, RNA recognition motif 2 [IPR034930]", "Matrin/U1-C, C2H2-type zinc finger [IPR000690]", "Matrin/U1-C-like, C2H2-type zinc finger [IPR003604]", "Mcm6, C-terminal winged-helix domain [IPR041024]", "Metallo-beta-lactamase [IPR001279]", "Metastasis-associated protein MTA1, R1 domain [IPR035170]", "Metaxin, glutathione S-transferase domain [IPR033468]", "Methionine synthase, B12-binding domain [IPR033706]", "Methionine--tRNA ligase, N-terminal [IPR041598]", "Methioninyl-tRNA synthetase core domain [IPR033911]", "Methionyl-tRNA synthetase, anticodon-binding domain [IPR041872]", "Methionyl/Leucyl tRNA synthetase [IPR015413]", "Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding [IPR013155]", "Methyl-CpG DNA binding [IPR001739]", "Methyl-CpG binding protein 2/3, C-terminal domain [IPR025884]", "Methyl-CpG-binding domain protein 2/3, p55-binding region [IPR032343]", "Methylglyoxal synthase-like domain [IPR011607]", "Methylthiotransferase, N-terminal [IPR013848]", "Methyltransferase domain 25 [IPR041698]", "Methyltransferase type 11 [IPR013216]", "Methyltransferase type 12 [IPR013217]", "Mib-herc2 [IPR010606]", "Midasin AAA lid domain 5 [IPR041190]", "Midasin, AAA lid domain 7 [IPR040848]", "Midline-1, COS domain [IPR040859]", "Minichromosome loss protein Mcl1, middle region [IPR022100]", "Mitochondrial apoptosis-inducing factor, C-terminal domain [IPR029324]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs [IPR034884]", "Mitochondrial degradasome RNA helicase subunit, C-terminal domain [IPR022192]", "Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564]", "Mitochondrial ribosomal protein L46 NUDIX [IPR033650]", "MnmE, helical domain [IPR025867]", "MoaB/Mog domain [IPR001453]", "Molybdenum cofactor sulfurase, C-terminal [IPR005302]", "Molybdopterin oxidoreductase [IPR006656]", "Molybdopterin oxidoreductase, 4Fe-4S domain [IPR006963]", "Mre11 nuclease, N-terminal metallophosphatase domain [IPR041796]", "Mre11, DNA-binding [IPR007281]", "Mu homology domain [IPR028565]", "Mu2, C-terminal domain [IPR043512]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal [IPR031717]", "Multiple myeloma tumor-associated protein 2-like, N-terminal [IPR019315]", "Myb domain [IPR017930]", "Myo-inositol-1-phosphate synthase, GAPDH-like [IPR013021]", "Myosin VI, cargo binding domain [IPR032412]", "Myosin head, motor domain [IPR001609]", "Myosin phosphatase-RhoA interacting protein, PH domain [IPR039597]", "Myosin tail [IPR002928]", "Myosin, N-terminal, SH3-like [IPR004009]", "Myotubularin-like phosphatase domain [IPR010569]", "Myristoyl-CoA:protein N-myristoyltransferase, C-terminal [IPR022677]", "Myristoyl-CoA:protein N-myristoyltransferase, N-terminal [IPR022676]", "N-acetylgalactosaminyltransferase [IPR045885]", "N-acetylneuraminic acid synthase, N-terminal [IPR013132]", "NAD(P) binding domain of glutamate dehydrogenase [IPR033922]", "NAD(P) transhydrogenase, alpha subunit, C-terminal [IPR024605]", "NAD-dependent epimerase/dehydratase [IPR001509]", "NAD/GMP synthase [IPR022310]", "NADH pyrophosphatase-like, N-terminal [IPR015375]", "NADH-quinone oxidoreductase, chain G, C-terminal [IPR015405]", "NADH-quinone oxidoreductase, subunit D [IPR001135]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain [IPR011538]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain [IPR019575]", "NADH:ubiquinone oxidoreductase intermediate-associated protein 30 [IPR013857]", "NADH:ubiquinone oxidoreductase, 30kDa subunit [IPR001268]", "NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding [IPR019574]", "NADH:ubiquinone oxidoreductase-like, 20kDa subunit [IPR006137]", "NADP transhydrogenase beta-like domain [IPR034300]", "NADP-dependent oxidoreductase domain [IPR023210]", "NDUFB9, LYR domain [IPR045292]", "NECAP, PHear domain [IPR012466]", "NEDD8 ultimate buster 1, ubiquitin-like domain [IPR041207]", "NET domain [IPR027353]", "NF-kappaB-repression factor, R3H domain [IPR034071]", "NFACT protein, C-terminal [IPR021846]", "NFACT, RNA-binding domain [IPR008532]", "NGN domain [IPR005100]", "NGN domain, eukaryotic [IPR039385]", "NHL2, NHL repeat domain [IPR045302]", "NLE [IPR012972]", "NOG, C-terminal [IPR012973]", "NOG1, N-terminal helical domain [IPR041623]", "NOP5, N-terminal [IPR012974]", "NOPS [IPR012975]", "NOSIC [IPR012976]", "NOT2/NOT3/NOT5, C-terminal [IPR007282]", "NP60, PWWP domain [IPR035501]", "NPL4, zinc-binding putative [IPR007716]", "NSD, Cys-His rich domain [IPR041306]", "NUC153 [IPR012580]", "NUC205 domain [IPR012584]", "NUDIX hydrolase [IPR020476]", "NUDIX hydrolase domain [IPR000086]", "NVL2, nucleolin binding domain [IPR031996]", "Nascent polypeptide-associated complex NAC domain [IPR002715]", "Neurobeachin-like, DUF1088 [IPR010508]", "Neurobeachin/BDCP, DUF4704 [IPR031570]", "Nicastrin, small lobe [IPR041084]", "Nicotinamide phosphoribosyltransferase, N-terminal domain [IPR041529]", "Nicotinate/nicotinamide phosphoribosyltransferase [IPR041525]", "Niemann-Pick C1, N-terminal [IPR032190]", "Nin one binding (NOB1) Zn-ribbon-like [IPR014881]", "Nischarin, PX domain [IPR037904]", "Nitric oxide synthase-interacting protein, zinc-finger [IPR031790]", "Nop domain [IPR002687]", "Nop2p [IPR011023]", "Npc2 like, ML domain [IPR033916]", "Nrap protein domain 1 [IPR035082]", "Nrap protein, domain 2 [IPR035367]", "Nrap protein, domain 3 [IPR035368]", "Nrap protein, domain 4 [IPR035369]", "Nrap protein, domain 5 [IPR035370]", "Nrap protein, domain 6 [IPR035371]", "Nuclear RNA export factor Tap, RNA-binding domain [IPR015245]", "Nuclear condensin complex subunit 3, C-terminal domain [IPR025977]", "Nuclear migration protein nudC [IPR032572]", "Nuclear pore complex protein Nup214, phenylalanine-glycine (FG) domain [IPR041553]", "Nuclear pore complex, NUP2/50/61 [IPR015007]", "Nuclear pore localisation protein NPL4, C-terminal [IPR007717]", "Nuclear pore localisation protein Npl4, ubiquitin-like domain [IPR024682]", "Nuclear protein 96 [IPR021967]", "Nuclear transport factor 2 domain [IPR002075]", "Nuclear transport factor 2, eukaryote [IPR018222]", "Nuclear-interacting partner of ALK/Rsm1-like [IPR013909]", "Nucleolar GTP-binding protein 1, Rossman-fold domain [IPR010674]", "Nucleolar GTP-binding protein 2, N-terminal domain [IPR012971]", "Nucleolar complex-associated protein 3, N-terminal [IPR011501]", "Nucleolar protein 7, C-terminal [IPR012579]", "Nucleolar protein 8, RNA recognition motif [IPR034138]", "Nucleolin, RNA recognition motif 1 [IPR034230]", "Nucleolin, RNA recognition motif 2 [IPR034233]", "Nucleolin, RNA recognition motif 3 [IPR034234]", "Nucleolin, RNA recognition motif 4 [IPR034235]", "Nucleophosmin, C-terminal [IPR032569]", "Nucleoplasmin core domain [IPR024057]", "Nucleoporin Nup153, N-terminal [IPR013913]", "Nucleoporin Nup188, N-terminal [IPR018864]", "Nucleoporin Nup54, alpha-helical domain [IPR025712]", "Nucleoporin, NSP1-like, C-terminal [IPR007758]", "Nucleoporin, Nup133/Nup155-like, C-terminal [IPR007187]", "Nucleoporin, Nup133/Nup155-like, N-terminal [IPR014908]", "Nucleoprotein TPR/MLP1 [IPR012929]", "Nucleoside diphosphate kinase-like domain [IPR034907]", "Nucleoside phosphorylase domain [IPR000845]", "Nucleotide exchange factor Fes1 [IPR013918]", "Nucleotidyl transferase domain [IPR005835]", "NudC N-terminal domain [IPR025934]", "NudC domain-containing protein 2, p23 domain [IPR037902]", "NuoE domain [IPR042128]", "Nup358/RanBP2 E3 ligase domain [IPR022011]", "Nup54, C-terminal interacting domain [IPR040985]", "NusG, N-terminal [IPR006645]", "O-GlcNAc transferase, C-terminal [IPR029489]", "OB-fold nucleic acid binding domain, AA-tRNA synthetase-type [IPR004365]", "OBG-type guanine nucleotide-binding (G) domain [IPR031167]", "OCRE domain [IPR041591]", "OTU domain [IPR003323]", "Occludin homology domain [IPR010844]", "Orotate phosphoribosyl transferase domain [IPR004467]", "Orotidine 5'-phosphate decarboxylase domain [IPR001754]", "Ovarian carcinoma immunoreactive antigen domain [IPR009764]", "Oxidoreductase FAD/NAD(P)-binding [IPR001433]", "Oxidoreductase, N-terminal domain [IPR041694]", "Oxoglutarate/iron-dependent dioxygenase [IPR005123]", "Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain [IPR019601]", "P-type ATPase, haloacid dehalogenase domain [IPR044492]", "P-type trefoil domain [IPR000519]", "PA domain [IPR003137]", "PABP, RNA recognition motif 2 [IPR045305]", "PACSIN1/PACSIN2, SH3 domain [IPR035743]", "PACSIN2, F-BAR domain [IPR037453]", "PADR1 domain [IPR012982]", "PAP/25A-associated [IPR002058]", "PARN, R3H domain [IPR034042]", "PB1 domain [IPR000270]", "PDIP3, RNA recognition motif [IPR034784]", "PDZ domain 6 [IPR041489]", "PDZ domain [IPR001478]", "PH-BEACH domain [IPR023362]", "PIK-related kinase [IPR014009]", "PIK-related kinase, FAT [IPR003151]", "PIN domain [IPR002716]", "PITH domain [IPR010400]", "PLAA family ubiquitin binding domain [IPR015155]", "PLD-like domain [IPR032803]", "POLO box domain [IPR000959]", "POPLD domain [IPR012590]", "POTRA domain [IPR034746]", "PP5, C-terminal metallophosphatase domain [IPR041753]", "PPIL4-like, cyclophilin domain [IPR035538]", "PPM-type phosphatase domain [IPR001932]", "PPP domain [IPR013235]", "PRMT5 arginine-N-methyltransferase [IPR035075]", "PRMT5, TIM barrel domain [IPR035247]", "PRMT5, oligomerisation domain [IPR035248]", "PRO8NT domain [IPR012591]", "PROCN domain [IPR012592]", "PROCT domain [IPR012984]", "PRP1 splicing factor, N-terminal [IPR010491]", "PRP8 domain IV core [IPR021983]", "PSF, NOPS domain [IPR034526]", "PSF, RNA recognition motif 1 [IPR034525]", "PSI domain [IPR016201]", "PSP, proline-rich [IPR006568]", "PSP1, RNA recognition motif 1 [IPR034522]", "PSP1, RNA recognition motif 2 [IPR034523]", "PTB/PI domain [IPR006020]", "PTBP1, RNA recognition motif 1 [IPR035000]", "PTBP1, RNA recognition motif 2-like [IPR021790]", "PTBP1, RNA recognition motif 3 [IPR035001]", "PUA domain [IPR002478]", "PUF60, RNA recognition motif 1 [IPR034209]", "PUF60, RNA recognition motif 2 [IPR034211]", "PUF60, RNA recognition motif 3 [IPR034212]", "PUL domain [IPR013535]", "PWI domain [IPR002483]", "PWWP domain [IPR000313]", "Paf1 complex subunit Cdc73, N-terminal domain [IPR032041]", "Palladin, C-terminal immunoglobulin-like domain [IPR033017]", "Palmitoyltransferase, DHHC domain [IPR001594]", "Pancreatic trypsin inhibitor Kunitz domain [IPR002223]", "Patatin-like phospholipase domain [IPR002641]", "Pentacotripeptide-repeat region of PRORP [IPR033443]", "Pep3/Vps18/deep orange [IPR007810]", "Peptidase C12, C-terminal domain [IPR041507]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase [IPR001578]", "Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394]", "Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615]", "Peptidase C2, calpain, catalytic domain [IPR001300]", "Peptidase C2, calpain, domain III [IPR022683]", "Peptidase C2, calpain, large subunit, domain III [IPR022682]", "Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal [IPR015211]", "Peptidase M1, membrane alanine aminopeptidase [IPR014782]", "Peptidase M12B, ADAM/reprolysin [IPR001590]", "Peptidase M12B, propeptide [IPR002870]", "Peptidase M13, C-terminal domain [IPR018497]", "Peptidase M13, N-terminal domain [IPR008753]", "Peptidase M14, carboxypeptidase A [IPR000834]", "Peptidase M16, C-terminal [IPR007863]", "Peptidase M16, N-terminal [IPR011765]", "Peptidase M16, middle/third domain [IPR032632]", "Peptidase M16C associated [IPR013578]", "Peptidase M17, leucyl aminopeptidase, C-terminal [IPR000819]", "Peptidase M17, leucyl aminopeptidase, N-terminal [IPR008283]", "Peptidase M20, dimerisation domain [IPR011650]", "Peptidase M24 [IPR000994]", "Peptidase M24, C-terminal domain [IPR032416]", "Peptidase M28 [IPR007484]", "Peptidase M3A/M3B catalytic domain [IPR001567]", "Peptidase M41 [IPR000642]", "Peptidase M41, FtsH extracellular [IPR011546]", "Peptidase M48 [IPR001915]", "Peptidase S16, Lon proteolytic domain [IPR008269]", "Peptidase S24/S26A/S26B/S26C [IPR015927]", "Peptidase S26 [IPR019533]", "Peptidase S53, activation domain [IPR015366]", "Peptidase S59, nucleoporin [IPR007230]", "Peptidase S8/S53 domain [IPR000209]", "Peptidase S8A, tripeptidyl peptidase II [IPR022229]", "Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375]", "Peptidase S9A, N-terminal domain [IPR023302]", "Peptidase family M60 domain [IPR031161]", "Peptide chain release factor class I [IPR000352]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type [IPR000297]", "Pericentriolar material 1 protein, C-terminal [IPR031446]", "Peripheral subunit-binding domain [IPR004167]", "Peroxiredoxin, C-terminal [IPR019479]", "Peroxisome membrane anchor protein Pex14p, N-terminal [IPR006785]", "PheRS DNA binding domain 2 [IPR040586]", "PheRS, DNA binding domain 1 [IPR040724]", "PheRS, DNA binding domain 3 [IPR040725]", "Phenylacetic acid degradation-related domain [IPR003736]", "Phenylalanine--tRNA ligase beta subunit, B1 domain [IPR040659]", "Phenylalanyl tRNA synthetase beta chain, core domain [IPR041616]", "Phenylalanyl-tRNA synthetase [IPR002319]", "Phosducin, thioredoxin-like domain [IPR024253]", "Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403]", "Phosphoadenosine phosphosulphate reductase [IPR002500]", "Phosphofructokinase domain [IPR000023]", "Phosphoglucose isomerase, SIS domain 1 [IPR035476]", "Phosphoglucose isomerase, SIS domain 2 [IPR035482]", "Phosphoinositide 3-kinase, accessory (PIK) domain [IPR001263]", "Phospholipase D/Transphosphatidylase [IPR001736]", "Phospholipase/carboxylesterase/thioesterase [IPR003140]", "Phospholipid/glycerol acyltransferase [IPR002123]", "Phosphopantetheine binding ACP domain [IPR009081]", "Phosphoribosylformylglycinamidine synthase, N-terminal [IPR040707]", "Phosphoribosylformylglycinamidine synthase, linker domain [IPR041609]", "Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain [IPR020561]", "Phosphoribosylglycinamide synthetase, C-domain [IPR020560]", "Phosphoribosylglycinamide synthetase, N-terminal [IPR020562]", "Phosphoribosyltransferase domain [IPR000836]", "Phosphorylated adapter RNA export protein, RNA-binding domain [IPR019385]", "Phosphotyrosine protein phosphatase I [IPR023485]", "Phox homology [IPR001683]", "Pinin/SDK [IPR006787]", "Pinin/SDK/MemA protein [IPR006786]", "Pirin, C-terminal domain [IPR008778]", "Pirin, N-terminal domain [IPR003829]", "Plasma membrane calcium transporting P-type ATPase, C-terminal [IPR022141]", "Pleckstrin homology domain 8 [IPR041680]", "Pleckstrin homology domain 9 [IPR041681]", "Pleckstrin homology domain [IPR001849]", "Pleckstrin homology domain, spectrin-type [IPR001605]", "Plectin/S10, N-terminal [IPR005326]", "Polo-like kinase 1, catalytic domain [IPR033702]", "Poly A polymerase, head domain [IPR002646]", "Poly(A) polymerase, RNA-binding domain [IPR007010]", "Poly(A) polymerase, central domain [IPR007012]", "Poly(A)-specific ribonuclease, RNA-binding [IPR014789]", "Poly(ADP-ribose) polymerase, catalytic domain [IPR012317]", "Poly(ADP-ribose) polymerase, regulatory domain [IPR004102]", "Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004]", "Polyamine biosynthesis domain [IPR030374]", "Polycomb protein, VEFS-Box [IPR019135]", "Polyketide synthase, C-terminal extension [IPR032821]", "Polyketide synthase, beta-ketoacyl synthase domain [IPR020841]", "Polyketide synthase, dehydratase domain [IPR020807]", "Polyketide synthase, enoylreductase domain [IPR020843]", "Polyketide synthase, ketoreductase domain [IPR013968]", "Polyketide synthase, phosphopantetheine-binding domain [IPR020806]", "Polymerase, nucleotidyl transferase domain [IPR002934]", "Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2 [IPR034798]", "Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain [IPR032319]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain [IPR015848]", "Polysaccharide biosynthesis domain [IPR021148]", "Pop1, N-terminal [IPR009723]", "Possible tRNA binding domain [IPR027992]", "Post-SET domain [IPR003616]", "Potassium channel tetramerisation-type BTB domain [IPR003131]", "Pre-PUA domain [IPR041366]", "Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term [IPR021718]", "Pre-mRNA polyadenylation factor Fip1 domain [IPR007854]", "Pre-mRNA processing factor 4 (PRP4)-like [IPR014906]", "Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal [IPR021786]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding [IPR019581]", "Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding [IPR019580]", "Pre-mRNA-splicing factor 19 [IPR013915]", "Pre-mRNA-splicing factor 3 [IPR013881]", "Pre-rRNA-processing protein Ipi1, N-terminal [IPR024679]", "Pre-rRNA-processing protein RIX1, N-terminal [IPR012583]", "Prenylcysteine lyase [IPR010795]", "Probable RNA-binding protein 19, RNA recognition motif 1 [IPR034418]", "Probable RNA-binding protein 19, RNA recognition motif 2 [IPR034417]", "Probable RNA-binding protein 19, RNA recognition motif 3 [IPR034419]", "Probable RNA-binding protein 19, RNA recognition motif 4 [IPR034420]", "Probable RNA-binding protein 19, RNA recognition motif 5 [IPR034423]", "Probable RNA-binding protein 19, RNA recognition motif 6 [IPR034421]", "Proliferating cell nuclear antigen, PCNA, C-terminal [IPR022649]", "Proliferating cell nuclear antigen, PCNA, N-terminal [IPR022648]", "Proline-tRNA ligase, class II, C-terminal [IPR016061]", "Prolyl 3,4-dihydroxylase TPA1/OFD1, N-terminal domain [IPR039558]", "Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]", "Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547]", "Prolyl 4-hydroxylase, alpha subunit [IPR006620]", "Prolyl-tRNA synthetase, catalytic domain [IPR033721]", "Propionyl-coenzyme A carboxylase, BT domain [IPR041265]", "Prostaglandin E synthase 2, C-terminal [IPR034335]", "Proteasomal ATPase OB C-terminal domain [IPR032501]", "Proteasome activator Blm10, mid region [IPR032430]", "Proteasome activator PA28, C-terminal domain [IPR003186]", "Proteasome activator PA28, N-terminal domain [IPR003185]", "Proteasome activator complex subunit 4 C-terminal domain [IPR021843]", "Proteasome alpha-subunit, N-terminal domain [IPR000426]", "Proteasome beta subunit, C-terminal [IPR024689]", "Proteasome component (PCI) domain [IPR000717]", "Protein Kinase B beta, catalytic domain [IPR034677]", "Protein Kinase B, pleckstrin homology domain [IPR039026]", "Protein O-mannosyl-transferase TMTC, DUF1736 [IPR013618]", "Protein RED, C-terminal [IPR012492]", "Protein disulfide-isomerase A3, first redox inactive TRX-like domain b [IPR041868]", "Protein disulfide-isomerase A4, TRX-like domain b [IPR041866]", "Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [IPR002219]", "Protein kinase domain [IPR000719]", "Protein kinase, C-terminal [IPR017892]", "Protein of unknown function DUF3504 [IPR021893]", "Protein of unknown function DUF3715 [IPR022188]", "Protein phosphatase 1 binding domain [IPR029334]", "Protein polybromo-1, Bromodomain 5 [IPR037968]", "Protein quaking, putative nuclear localisation signal [IPR032367]", "Protein-only RNase P, C-terminal [IPR031595]", "Protein-tyrosine phosphatase, catalytic [IPR003595]", "Prp31 C-terminal [IPR019175]", "Pseudouridine synthase I, TruA, alpha/beta domain [IPR020097]", "Pseudouridine synthase II, N-terminal [IPR002501]", "Pseudouridine synthase, TruD, insertion domain [IPR011760]", "Pterin-binding domain [IPR000489]", "Pumilio homology domain [IPR033133]", "PurE domain [IPR000031]", "PurM-like, C-terminal domain [IPR010918]", "PurM-like, N-terminal domain [IPR016188]", "Putative 5-3 exonuclease [IPR004859]", "Putative RNA methylase domain [IPR000241]", "Putative RNA-binding protein 27, RNA recognition motif [IPR034451]", "Putative WW-binding domain and destruction box [IPR033461]", "Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain [IPR004099]", "Pyrroline-5-carboxylate reductase, catalytic, N-terminal [IPR028939]", "Pyrroline-5-carboxylate reductase, dimerisation domain [IPR029036]", "Pyruvate carboxyltransferase [IPR000891]", "Pyruvate kinase, C-terminal [IPR015795]", "Pyruvate kinase, barrel [IPR015793]", "R3H domain [IPR001374]", "RABX5, catalytic core helical domain [IPR041545]", "RAD23A/RAD23B, UBA1 domain [IPR041811]", "RAD50, zinc hook [IPR013134]", "RAD51 interacting motif [IPR031419]", "RAP domain [IPR013584]", "RBM10, OCRE domain [IPR035618]", "RBM12, RNA recognition motif 1 [IPR034591]", "RBM12, RNA recognition motif 2 [IPR034594]", "RBM12, RNA recognition motif 3 [IPR034855]", "RBM12, RNA recognition motif 4 [IPR034856]", "RBM12, RNA recognition motif 5 [IPR034854]", "RBM14, RNA recognition motif 1 [IPR034506]", "RBM14, RNA recognition motif 2 [IPR034507]", "RBM15, RNA recognition motif 1 [IPR034470]", "RBM15, RNA recognition motif 2 [IPR034472]", "RBM15, RNA recognition motif 3 [IPR034473]", "RBM1CTR [IPR012604]", "RBM25, RNA recognition motif [IPR034268]", "RBM26, RNA recognition motif 1 [IPR034859]", "RBM26-like, RNA recognition motif 2 [IPR039511]", "RBM3/CIRBP, RNA recognition motif [IPR034278]", "RBM34, RNA recognition motif 1 [IPR034220]", "RBM34, RNA recognition motif 2 [IPR034221]", "RBM4, RNA recognition motif 1 [IPR034897]", "RBM4, RNA recognition motif 2 [IPR034898]", "RBM45, RNA recognition motif 1 [IPR034203]", "RBM45, RNA recognition motif 2 [IPR034206]", "RBM45, RNA recognition motif 3 [IPR034207]", "RBM45, RNA recognition motif 4 [IPR034208]", "RBM8, RNA recognition motif [IPR033744]", "RDD [IPR010432]", "RED-like, N-terminal [IPR012916]", "RH1 domain [IPR034743]", "RH2 domain [IPR034744]", "RHIM domain [IPR025735]", "RII binding domain [IPR018459]", "RING-type zinc-finger, LisH dimerisation motif [IPR027370]", "RIO kinase [IPR000687]", "RIO2 kinase winged helix domain, N-terminal [IPR015285]", "RIP1, Death domain [IPR037934]", "RL domain [IPR041252]", "RLI, domain 1 [IPR034348]", "RNA 3'-terminal phosphate cyclase domain [IPR023797]", "RNA 3'-terminal phosphate cyclase, insert domain [IPR013791]", "RNA binding activity-knot of a chromodomain [IPR025995]", "RNA exonuclease 4, DEDDh 3'-5' exonuclease domain [IPR037431]", "RNA helicase UPF1, 1B domain [IPR040812]", "RNA helicase UPF1, Cys/His rich zinc-binding domain [IPR018999]", "RNA helicase, DEAD-box type, Q motif [IPR014014]", "RNA polymerase III Rpc82, C -terminal [IPR008806]", "RNA polymerase III subunit RPC82-related, helix-turn-helix [IPR013197]", "RNA polymerase Rpb1, domain 1 [IPR007080]", "RNA polymerase Rpb1, domain 3 [IPR007066]", "RNA polymerase Rpb1, domain 4 [IPR007083]", "RNA polymerase Rpb1, domain 5 [IPR007081]", "RNA polymerase Rpb1, domain 6 [IPR007075]", "RNA polymerase Rpb1, domain 7 [IPR007073]", "RNA polymerase Rpb2, domain 2 [IPR007642]", "RNA polymerase Rpb2, domain 3 [IPR007645]", "RNA polymerase Rpb2, domain 4 [IPR007646]", "RNA polymerase Rpb2, domain 5 [IPR007647]", "RNA polymerase Rpb2, domain 7 [IPR007641]", "RNA polymerase Rpb7-like , N-terminal [IPR005576]", "RNA polymerase, N-terminal [IPR006592]", "RNA polymerase, Rpb5, N-terminal [IPR005571]", "RNA polymerase, alpha subunit [IPR000722]", "RNA polymerase, beta subunit, protrusion [IPR007644]", "RNA polymerase, subunit H/Rpb5 C-terminal [IPR000783]", "RNA recognition motif domain [IPR000504]", "RNA recognition motif domain, eukaryote [IPR003954]", "RNA recognition motif, spliceosomal PrP8 [IPR019582]", "RNA-binding S4 domain [IPR002942]", "RNA-binding domain, S1 [IPR022967]", "RNA-binding protein 10, RNA recognition motif 2 [IPR034992]", "RNA-binding protein 5, RNA recognition motif 1 [IPR034991]", "RNA-binding protein 5, RNA recognition motif 2 [IPR034993]", "RNA-binding protein Musashi homologue, RNA recognition motif 1 [IPR034130]", "RNA-binding protein Musashi homologue, RNA recognition motif 2 [IPR034126]", "RNA-polymerase II-associated protein 3-like, C-terminal domain [IPR025986]", "RNA-recognition motif (RRM) Nup35-type domain [IPR007846]", "RNPS1, RNA recognition motif [IPR034201]", "RNase L inhibitor RLI-like, possible metal-binding domain [IPR007209]", "ROCK, Rho binding domain [IPR015008]", "ROK, N-terminal [IPR012987]", "RPN1, N-terminal [IPR040892]", "RPN13, DEUBAD domain [IPR032368]", "RQC domain [IPR018982]", "RUN domain [IPR004012]", "RZZ complex, subunit KNTC1/ROD, C-terminal [IPR019527]", "Rab geranylgeranyltransferase, alpha subunit, insert-domain [IPR009087]", "Rab-GTPase-TBC domain [IPR000195]", "Rab-binding domain FIP-RBD [IPR019018]", "Rab3-GAP regulatory subunit, N-terminal [IPR032839]", "Rab3GAP catalytic subunit, C-terminal [IPR045698]", "Rab3GAP catalytic subunit, conserved domain [IPR026147]", "Rab3GAP regulatory subunit, C-terminal [IPR029257]", "Rad21/Rec8-like protein, C-terminal, eukaryotic [IPR006909]", "Rad21/Rec8-like protein, N-terminal [IPR006910]", "Rad50, ATP-binding cassette domain [IPR045171]", "Rad50/SbcC-type AAA domain [IPR038729]", "Radical SAM [IPR007197]", "Raly, RNA recognition motif [IPR034502]", "Ran binding domain [IPR000156]", "Ran binding protein 9/10, SPRY domain [IPR035782]", "Ran-GTPase activating protein 1, C-terminal [IPR009109]", "Ran-specific GTPase-activating protein 1, Ran-binding domain [IPR045256]", "Rap/Ran-GAP domain [IPR000331]", "Ras GTPase-activating domain [IPR001936]", "Ras-associating (RA) domain [IPR000159]", "RasGAP protein, C-terminal [IPR000593]", "RecF/RecN/SMC, N-terminal [IPR003395]", "RecQ helicase-like 5 [IPR010716]", "Redoxin [IPR013740]", "Replication factor A, C-terminal [IPR013955]", "Replication factor C, C-terminal [IPR013748]", "Replication factor-A protein 1, N-terminal [IPR007199]", "Replication protein A, OB domain [IPR031657]", "Reticulon [IPR003388]", "Rho GTPase-binding/formin homology 3 (GBD/FH3) domain [IPR014768]", "Rho-associated protein kinase 2, HR1 domain [IPR037311]", "Rhodanese-like domain [IPR001763]", "Ribonuclease H1, N-terminal [IPR011320]", "Ribonuclease HII/HIII domain [IPR024567]", "Ribonuclease II/R [IPR001900]", "Ribonuclease, PIN domain [IPR033411]", "Ribonucleoprotein PTB-binding 1, RNA recognition motif 1 [IPR034633]", "Ribonucleotide reductase large subunit, C-terminal [IPR000788]", "Ribonucleotide reductase large subunit, N-terminal [IPR013509]", "Ribonucleotide reductase, class I , alpha subunit [IPR013346]", "Ribose-phosphate pyrophosphokinase, N-terminal domain [IPR029099]", "Ribosomal L28e/Mak16 [IPR029004]", "Ribosomal Protein L6, KOW domain [IPR041997]", "Ribosomal Proteins L2, RNA binding domain [IPR022666]", "Ribosomal RNA adenine methylase transferase, N-terminal [IPR020598]", "Ribosomal RNA methyltransferase FtsJ domain [IPR002877]", "Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381 [IPR024576]", "Ribosomal RNA methyltransferase, Spb1, C-terminal [IPR012920]", "Ribosomal RNA small subunit methyltransferase F, N-terminal [IPR031341]", "Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain [IPR029190]", "Ribosomal RNA-processing protein 7, C-terminal domain [IPR024326]", "Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906]", "Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A [IPR023573]", "Ribosomal protein L10e/L16 [IPR016180]", "Ribosomal protein L11, C-terminal [IPR020783]", "Ribosomal protein L11, N-terminal [IPR020784]", "Ribosomal protein L14, KOW motif [IPR041985]", "Ribosomal protein L14e domain [IPR002784]", "Ribosomal protein L18e/L15P [IPR021131]", "Ribosomal protein L19, eukaryotic [IPR033935]", "Ribosomal protein L19/L19e [IPR000196]", "Ribosomal protein L2, C-terminal [IPR022669]", "Ribosomal protein L23/L25, N-terminal [IPR005633]", "Ribosomal protein L26/L24, KOW domain [IPR041988]", "Ribosomal protein L30, N-terminal [IPR012988]", "Ribosomal protein L30, ferredoxin-like fold domain [IPR016082]", "Ribosomal protein L46, N-terminal [IPR021757]", "Ribosomal protein L5 eukaryotic, C-terminal [IPR025607]", "Ribosomal protein L5, C-terminal [IPR031309]", "Ribosomal protein L5, N-terminal [IPR031310]", "Ribosomal protein L6, N-terminal [IPR005568]", "Ribosomal protein L6, alpha-beta domain [IPR020040]", "Ribosomal protein L7, eukaryotic/archaeal [IPR035808]", "Ribosomal protein L7/L12, C-terminal [IPR013823]", "Ribosomal protein L7/L12, oligomerisation [IPR008932]", "Ribosomal protein L7Ae/L30e/S12e/Gadd45 [IPR004038]", "Ribosomal protein L9, N-terminal [IPR020070]", "Ribosomal protein S10 domain [IPR027486]", "Ribosomal protein S13/S15, N-terminal [IPR012606]", "Ribosomal protein S23/S25, mitochondrial [IPR023611]", "Ribosomal protein S24/S35, mitochondrial, conserved domain [IPR019349]", "Ribosomal protein S3, C-terminal [IPR001351]", "Ribosomal protein S4, KOW domain [IPR041982]", "Ribosomal protein S4/S9, N-terminal [IPR001912]", "Ribosomal protein S4e, N-terminal [IPR013843]", "Ribosomal protein S4e, central region [IPR013845]", "Ribosomal protein S5, C-terminal [IPR005324]", "Ribosomal protein S5, N-terminal [IPR013810]", "Ribosomal protein S6 kinase alpha-3, C-terminal catalytic domain [IPR041905]", "Ribosomal protein S7 domain [IPR023798]", "Ribosomal protein/NADH dehydrogenase domain [IPR007741]", "Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034]", "Ribosome biogenesis protein Bms1, N-terminal [IPR037875]", "Ribosome maturation protein Sdo1/SBDS, C-terminal [IPR018978]", "Ribosome maturation protein Sdo1/SBDS, N-terminal [IPR019783]", "Ribosome receptor lysine/proline rich [IPR007794]", "Ribosome recycling factor domain [IPR023584]", "Ribosome-associated complex head domain [IPR032003]", "Ricin B, lectin domain [IPR000772]", "Roadblock/LAMTOR2 domain [IPR004942]", "Rpn11/EIF3F, C-terminal [IPR024969]", "Rpn13/ADRM1, Pru domain [IPR044868]", "RrmJ-type ribose 2-O-methyltransferase domain [IPR025816]", "Rrp40, S1 domain [IPR037319]", "Rrp44-like cold shock domain [IPR033771]", "Rrp7, RRM-like N-terminal domain [IPR040447]", "Rrp7A, RNA recognition motif [IPR034890]", "RuvB-like, AAA-lid domain [IPR041048]", "S-adenosyl-L-homocysteine hydrolase, NAD binding domain [IPR015878]", "S-adenosylmethionine synthetase, C-terminal [IPR022630]", "S-adenosylmethionine synthetase, N-terminal [IPR022628]", "S-adenosylmethionine synthetase, central domain [IPR022629]", "S1 domain [IPR003029]", "S1-like RNA binding domain [IPR025223]", "S100/CaBP-9k-type, calcium binding, subdomain [IPR013787]", "SAB domain [IPR007477]", "SAC domain [IPR002013]", "SAF domain [IPR013974]", "SAICAR synthetase/ADE2, N-terminal [IPR028923]", "SAM-dependent methyltransferase RsmB/NOP2-type [IPR001678]", "SANT domain [IPR017884]", "SANT/Myb domain [IPR001005]", "SAP domain [IPR003034]", "SART3, RNA recognition motif 1 [IPR034217]", "SART3, RNA recognition motif 2 [IPR034218]", "SCAF8, RNA recognition motif [IPR034370]", "SCP2 sterol-binding domain [IPR003033]", "SEC23-interacting protein, SAM domain [IPR037603]", "SEP domain [IPR012989]", "SERRATE/Ars2 , C-terminal [IPR007042]", "SERRATE/Ars2, N-terminal [IPR021933]", "SET domain [IPR001214]", "SF3A2 domain [IPR031781]", "SF3A3 domain [IPR031774]", "SF3B4, RNA recognition motif 1 [IPR034158]", "SF3B4, RNA recognition motif 2 [IPR034159]", "SF3B6, RNA recognition motif [IPR034150]", "SGNH hydrolase-type esterase domain [IPR013830]", "SGS domain [IPR007699]", "SGTA, homodimerisation domain [IPR032374]", "SH2 domain [IPR000980]", "SH3 domain [IPR001452]", "SHARP, RNA recognition motif 1 [IPR034172]", "SHARP, RNA recognition motif 2 [IPR034173]", "SHARP, RNA recognition motif 3 [IPR034174]", "SHARP, RNA recognition motif 4 [IPR034175]", "SIS domain [IPR001347]", "SKI-interacting protein SKIP, SNW domain [IPR004015]", "SKP1 component, POZ domain [IPR016073]", "SKP1 component, dimerisation [IPR016072]", "SLC12A transporter, C-terminal [IPR018491]", "SLIDE domain [IPR015195]", "SLIRP, RNA recognition motif [IPR034152]", "SMAP1-like, ArfGAP domain [IPR044732]", "SMARCA1, N-terminal [IPR044755]", "SMARCC, C-terminal [IPR032451]", "SMARCC, N-terminal [IPR032450]", "SMARCC, SWIRM-associated domain [IPR032448]", "SMCs flexible hinge [IPR010935]", "SMYD3, SET domain [IPR044420]", "SNARE-complex protein Syntaxin-18, N-terminal [IPR019529]", "SNF2, N-terminal [IPR000330]", "SNX2, PX domain [IPR037918]", "SNX6, PX domain [IPR042136]", "SNX9, SH3 domain [IPR035558]", "SPF45, RNA recognition motif [IPR034653]", "SPRY domain [IPR003877]", "SPRY-associated [IPR006574]", "SR140, RNA recognition motif [IPR035009]", "SRA-YDG [IPR003105]", "SRCR domain [IPR001190]", "SRCR-like domain [IPR017448]", "SRP9 domain [IPR039432]", "SRSF1, RNA recognition motif 1 [IPR034520]", "SRSF7, RNA recognition motif [IPR034651]", "SRSF9, RNA recognition motif 1 [IPR034503]", "SRSF9, RNA recognition motif 2 [IPR034995]", "SSRP1 domain [IPR024954]", "STAG [IPR013721]", "STAR protein, homodimerisation region [IPR032377]", "START domain [IPR002913]", "STAT transcription factor, DNA-binding [IPR013801]", "STAT transcription factor, all-alpha domain [IPR013800]", "STAT transcription factor, protein interaction [IPR013799]", "STAT3, SH2 domain [IPR035855]", "STI1 domain [IPR041243]", "STRBP, first double-stranded RNA binding domain [IPR044472]", "SUI1 domain [IPR001950]", "SUMO-activating enzyme subunit 2, C-terminal domain [IPR032426]", "SUN domain [IPR012919]", "SUZ-C domain [IPR024642]", "SWAP/Surp [IPR000061]", "SWI/SNF-like complex subunit BAF250, C-terminal [IPR033388]", "SWIB domain [IPR019835]", "SWIB/MDM2 domain [IPR003121]", "SWIRM domain [IPR007526]", "Saccharopine dehydrogenase, NADP binding domain [IPR005097]", "Saccharopine dehydrogenase-like, C-terminal [IPR032095]", "Sam68, tyrosine-rich domain [IPR032335]", "Saposin B type domain [IPR008139]", "Schlafen group 3-like, DNA/RNA helicase domain [IPR018647]", "Schlafen, AlbA_2 domain [IPR007421]", "Sec16, central conserved domain [IPR024340]", "Sec23, C-terminal [IPR037550]", "Sec23/Sec24 beta-sandwich [IPR012990]", "Sec23/Sec24, helical domain [IPR006900]", "Sec23/Sec24, trunk domain [IPR006896]", "Sec24-like, trunk domain [IPR041742]", "Sec63 domain [IPR004179]", "Sec7 domain [IPR000904]", "Second polo-box domain [IPR033695]", "Sedolisin domain [IPR030400]", "Senescence/spartin-associated, C-terminal [IPR009686]", "Sentrin-specific protease 3/5, conserved domain [IPR045577]", "Septin-type guanine nucleotide-binding (G) domain [IPR030379]", "Sequestosome-1, PB1 domain [IPR034866]", "Sequestosome-1, UBA domain [IPR033741]", "Serine aminopeptidase, S33 [IPR022742]", "Serine hydroxymethyltransferase-like domain [IPR039429]", "Serine-tRNA ligase catalytic core domain [IPR033729]", "Serine-tRNA synthetase, type1, N-terminal [IPR015866]", "Serine-threonine protein phosphatase, N-terminal [IPR031675]", "Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245]", "Serine/arginine-rich splicing factor SRSF4-like, RNA recognition motif 1 [IPR035585]", "Serine/threonine-protein PRP4, catalytic domain [IPR044092]", "Serine/threonine-protein kinase N, C2 domain [IPR037784]", "Serine/threonine-protein kinase N, first HR1 domain [IPR037313]", "Serine/threonine-protein kinase Nek9, catalytic domain [IPR042767]", "Serine/threonine-protein kinase Rio2 [IPR030484]", "Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase [IPR006186]", "Serpin H1, serpin domain [IPR033830]", "Serpin domain [IPR023796]", "Siah interacting protein, N-terminal [IPR015120]", "Sialidase [IPR011040]", "Signal recognition particle SRP54, helical bundle [IPR013822]", "Signal recognition particle receptor, alpha subunit, N-terminal [IPR007222]", "Signal recognition particle subunit SRP68, RNA-binding domain [IPR034652]", "Signal recognition particle, SRP54 subunit, GTPase domain [IPR000897]", "Signal recognition particle, SRP54 subunit, M-domain [IPR004125]", "Signal recognition particle, SRP72 subunit, RNA-binding [IPR013699]", "Sin3, C-terminal [IPR031693]", "Sirtuin family, catalytic core domain [IPR026590]", "Sister chromatid cohesion C-terminal domain [IPR024986]", "Ski2, N-terminal domain [IPR040801]", "Small G protein signalling modulator 1/2, Rab-binding domain [IPR021935]", "Small GTP-binding protein domain [IPR005225]", "Small nuclear ribonucleoprotein D1 [IPR034102]", "Small-subunit processome, Utp12 [IPR007148]", "Small-subunit processome, Utp13 [IPR013934]", "Small-subunit processome, Utp21 [IPR007319]", "Smc1, ATP-binding cassette domain [IPR028468]", "Smc2, ATP-binding cassette domain [IPR027120]", "Snf2, ATP coupling domain [IPR029295]", "Snu114, GTP-binding domain [IPR044121]", "Sof1-like protein [IPR007287]", "Solute carrier family 3 member 2, N-terminal domain [IPR031984]", "Sortilin, C-terminal [IPR031777]", "Sortilin, N-terminal [IPR031778]", "Sorting Nexin 1, PX domain [IPR034901]", "Sorting nexin Vps5-like, C-terminal [IPR015404]", "Sorting nexin protein, WASP-binding domain [IPR019497]", "Sorting nexin, N-terminal [IPR005329]", "Sorting nexin-9, BAR domain [IPR037425]", "Sorting nexin-9, PX domain [IPR037426]", "Spen paralogue and orthologue SPOC, C-terminal [IPR012921]", "Spen paralogue/orthologue C-terminal, metazoa [IPR010912]", "Spermidine synthase, tetramerisation domain [IPR035246]", "Splicing factor 1, helix-hairpin domain [IPR032570]", "Splicing factor 3A subunit 1, conserved domain [IPR022030]", "Splicing factor 3A subunit 1, ubiquitin domain [IPR035563]", "Splicing factor 3B subunit 1 [IPR015016]", "Splicing factor ELAV/Hu, RNA recognition motif 1 [IPR034775]", "Splicing factor RBM39, linker [IPR029123]", "Splicing factor SF3a60 /Prp9 subunit, C-terminal [IPR024598]", "Splicing factor SF3a60 binding domain [IPR021966]", "Spt5 C-terminal domain [IPR024945]", "Spt5 transcription elongation factor, N-terminal [IPR022581]", "Spt5, KOW domain repeat 1 [IPR041973]", "Spt5, KOW domain repeat 2 [IPR041975]", "Spt5, KOW domain repeat 3 [IPR041976]", "Spt5, KOW domain repeat 4 [IPR041977]", "Spt5, KOW domain repeat 5 [IPR041978]", "Spt5, KOW domain repeat 6 [IPR041980]", "Spt6 acidic, N-terminal domain [IPR028083]", "Spt6, SH2 domain [IPR035420]", "Spt6, SH2 domain, C terminus [IPR035018]", "Spt6, SH2 domain, N terminus [IPR035019]", "Squalene cyclase, C-terminal [IPR032696]", "Squalene cyclase, N-terminal [IPR032697]", "Squalene epoxidase [IPR013698]", "Srp40, C-terminal [IPR007718]", "StAR-related lipid transfer protein 3, C-terminal [IPR029867]", "Staphylococcal nuclease (SNase-like), OB-fold [IPR016071]", "Staufen 1, third double-stranded RNA binding domain [IPR044475]", "Staufen 2, first double-stranded RNA binding domain [IPR044476]", "Staufen 2, fourth double-stranded RNA binding domain [IPR044474]", "Staufen 2, second double-stranded RNA binding domain [IPR044464]", "Staufen 2, third double-stranded RNA binding domain [IPR044473]", "Staufen, C-terminal [IPR032478]", "Steadiness box (SB) domain [IPR017916]", "Sterile alpha motif domain [IPR001660]", "Sterol-sensing domain [IPR000731]", "Striatin, N-terminal [IPR013258]", "Strictosidine synthase, conserved region [IPR018119]", "Stromalin conservative domain [IPR020839]", "Structural maintenance of chromosomes 3, ABC domain, eukaryotic [IPR041741]", "Structural maintenance of chromosomes 4, ABC domain, eukaryotic [IPR041738]", "Succinate dehydogenase/fumarate reductase N-terminal [IPR025192]", "Sulfatase, N-terminal [IPR000917]", "Sulfhydryl oxidase, Trx-like domain [IPR041269]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain [IPR040986]", "Sulphate adenylyltransferase [IPR002650]", "Sulphate adenylyltransferase catalytic domain [IPR024951]", "Suppressor of forked [IPR008847]", "Suppressor of white apricot, N-terminal domain [IPR019147]", "Survival motor neuron [IPR010304]", "Sushi/SCR/CCP domain [IPR000436]", "Suv3, C-terminal domain 1 [IPR041082]", "Suv3, DEXQ-box helicase domain [IPR044774]", "Suv3, N-terminal [IPR041453]", "Symplekin C-terminal [IPR022075]", "Symplekin/Pta1, N-terminal [IPR032460]", "Synaptic functional regulator FMRP, KH0 domain [IPR040472]", "Synaptotagmin, SMP domain [IPR039010]", "Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468]", "Syntaxin, N-terminal domain [IPR006011]", "Syntaxin-8, SNARE domain [IPR041875]", "TAP C-terminal (TAP-C) domain [IPR005637]", "TAR DNA-binding protein 43, N-terminal [IPR041105]", "TATA box binding protein associated factor (TAF) [IPR004823]", "TATA-binding protein interacting (TIP20) [IPR013932]", "TBCE, ubiquitin-like (Ubl) domain [IPR044079]", "TCB1D9/TCB1D9B, PH-GRAM domain 1 [IPR036014]", "TCB1D9/TCB1D9B, PH-GRAM domain 2 [IPR036017]", "TFG box [IPR025768]", "TFG, PB1 domain [IPR034857]", "TFIIEalpha/SarR/Rpc3 HTH domain [IPR024550]", "TGS [IPR004095]", "THIF-type NAD/FAD binding fold [IPR000594]", "THO complex subunit 2, N-terminal domain [IPR032302]", "THO complex, subunitTHOC2, C-terminal [IPR021418]", "THO complex, subunitTHOC2, N-terminal [IPR021726]", "THUMP domain [IPR004114]", "TIA-1, RNA recognition motif 2 [IPR034830]", "TIA-1, RNA recognition motif 3 [IPR034832]", "TIAR, RNA recognition motif 1 [IPR034492]", "TIAR, RNA recognition motif 2 [IPR034494]", "TIAR, RNA recognition motif 3 [IPR034496]", "TIF1-beta, RING finger, HC subclass [IPR042713]", "TIP49, P-loop domain [IPR010339]", "TOG domain [IPR034085]", "TOPK, catalytic domain [IPR041989]", "TOPRIM domain [IPR006171]", "TPX2 central domain [IPR027330]", "TPX2, C-terminal [IPR027329]", "TRAM domain [IPR002792]", "TRAM/LAG1/CLN8 homology domain [IPR006634]", "TRAM1-like protein [IPR013599]", "TRASH domain [IPR011017]", "TRIAD supradomain [IPR044066]", "TRIM25, PRY/SPRY domain [IPR042753]", "TROVE domain [IPR008858]", "TUTase nucleotidyltransferase domain [IPR045100]", "Talin, N-terminal F0 domain [IPR032425]", "Talin, central [IPR015224]", "Talin-1/2, rod-segment [IPR037438]", "Tankyrase 1-binding protein, C-terminal [IPR032764]", "Target SNARE coiled-coil homology domain [IPR000727]", "Telomere length regulation protein, conserved domain [IPR019337]", "Telomere-associated protein Rif1, N-terminal [IPR022031]", "Tensin phosphatase, C2 domain [IPR014020]", "Tensin-type phosphatase domain [IPR029023]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain [IPR020631]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain [IPR020630]", "Tetratricopeptide repeat-like domain [IPR018704]", "Tetratricopeptide, SHNi-TPR domain [IPR019544]", "Tfc3, extended winged-helix domain [IPR035625]", "Thg1 C-terminal domain [IPR025845]", "Thiamine pyrophosphate enzyme, C-terminal TPP-binding [IPR011766]", "Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain [IPR012001]", "Thiamine pyrophosphate enzyme, central domain [IPR012000]", "Thioesterase [IPR001031]", "Thioesterase domain [IPR006683]", "Thiolase, C-terminal [IPR020617]", "Thiolase, N-terminal [IPR020616]", "Thioredoxin domain [IPR013766]", "Thioredoxin domain-containing protein 17-like domain [IPR010357]", "Thioredoxin-like fold [IPR012336]", "Thioredoxin-related transmembrane protein 2, thioredoxin domain [IPR037463]", "Threonine-tRNA ligase catalytic core domain [IPR033728]", "Threonyl/alanyl tRNA synthetase, SAD [IPR012947]", "Thymidylate kinase-like domain [IPR039430]", "Thymidylate synthase/dCMP hydroxymethylase domain [IPR023451]", "Tim10-like [IPR004217]", "Tim44-like domain [IPR007379]", "Timeless, C-terminal [IPR007725]", "Timeless, N-terminal [IPR006906]", "Toll-interacting protein, C2 domain [IPR037301]", "Toll-interacting protein, CUE domain [IPR041799]", "TopBP1, first BRCT domain [IPR044737]", "Topoisomerase I C-terminal domain [IPR025834]", "Trafficking protein particle complex subunit 11 [IPR021773]", "Trafficking protein particle complex subunit 11, C-terminal [IPR025876]", "Trans-isoprenyl diphosphate synthases, head-to-head [IPR033904]", "Transcription elongation factor S-II, central domain [IPR003618]", "Transcription elongation factor Spt6, YqgF domain [IPR028231]", "Transcription elongation factor Spt6, helix-hairpin-helix motif [IPR032706]", "Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type [IPR003617]", "Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958]", "Transcription factor IIIC subunit 5, HTH domain [IPR019136]", "Transcription factor IIIC subunit Tfc1/Sfc1, triple barrel domain [IPR041499]", "Transcription factor IIIC, 90kDa subunit, N-terminal [IPR024761]", "Transcription factor IIIC, putative zinc-finger [IPR024764]", "Transcription factor IIS, N-terminal [IPR017923]", "Transcription factor TFE/TFIIEalpha HTH domain [IPR017919]", "Transcription factor TFIIE alpha subunit, C-terminal [IPR021600]", "Transcription initiation factor IIE subunit alpha, N-terminal [IPR002853]", "Transcription termination and cleavage factor, C-terminal domain [IPR026896]", "Transcriptional coactivator p15 (PC4), C-terminal [IPR003173]", "Transcriptional repressor p66, coiled-coil MBD2-interaction domain [IPR032346]", "Transferrin receptor protein 1/2, PA domain [IPR037324]", "Transferrin receptor-like, dimerisation domain [IPR007365]", "Transketolase, C-terminal domain [IPR033248]", "Transketolase, N-terminal [IPR005474]", "Transketolase-like, pyrimidine-binding domain [IPR005475]", "Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038]", "Translation elongation factor EFG/EF2, domain IV [IPR005517]", "Translation elongation factor EFTs/EF1B, dimerisation [IPR014039]", "Translation elongation factor EFTu-like, domain 2 [IPR004161]", "Translation elongation factor EFTu/EF1A, C-terminal [IPR004160]", "Translation elongation factor, IF5A C-terminal [IPR020189]", "Translation initiation factor IF- 2, domain 3 [IPR023115]", "Translation initiation factor IF-2, domain II [IPR044145]", "Translation initiation factor IF2/IF5 domain [IPR002735]", "Translation initiation factor eIF-2B subunit epsilon, N-terminal [IPR035543]", "Translation initiation factor eIF-2B subunit epsilon, W2 domain [IPR044123]", "Translation initiation factor, beta propellor-like domain [IPR013979]", "Translational (tr)-type GTP-binding domain [IPR000795]", "Translationally controlled tumour protein (TCTP) domain [IPR034737]", "Translocon Sec61/SecY, plug domain [IPR019561]", "Transmembrane protein 201, C-terminal [IPR018861]", "Treacle protein domain [IPR003993]", "Tripeptidyl-peptidase II domain [IPR034051]", "TrmE-type guanine nucleotide-binding domain [IPR031168]", "Tuberin, N-terminal [IPR024584]", "Tuberin-type domain [IPR018515]", "Tubulin binding cofactor C-like domain [IPR012945]", "Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]", "Tubulin/FtsZ, GTPase domain [IPR003008]", "Tudor domain [IPR002999]", "Tumour suppressor p53-binding protein-1 Tudor domain [IPR015125]", "Tyrosine-protein kinase BAZ1B, bromodomain [IPR037375]", "Tyrosine-protein kinase ephrin type A/B receptor-like [IPR011641]", "Tyrosine-protein kinase, catalytic domain [IPR020635]", "Tyrosine-specific protein phosphatase, PTPase domain [IPR000242]", "Tyrosine-specific protein phosphatases domain [IPR000387]", "U-box domain [IPR003613]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 1 [IPR034407]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 2 [IPR034409]", "U1 small nuclear ribonucleoprotein of 70kDa N-terminal [IPR022023]", "U1-C, C2H2-type zinc finger [IPR013085]", "U2A'/phosphoprotein 32 family A, C-terminal [IPR003603]", "U3 small nucleolar RNA-associated protein 10, N-terminal [IPR022125]", "U3 small nucleolar RNA-associated protein 15, C-terminal [IPR018983]", "UAS [IPR006577]", "UBX domain [IPR001012]", "UDP-glucose/GDP-mannose dehydrogenase, C-terminal [IPR014027]", "UDP-glucose/GDP-mannose dehydrogenase, N-terminal [IPR001732]", "UDP-glucose/GDP-mannose dehydrogenase, dimerisation [IPR014026]", "UDP-glucose:glycoprotein glucosyltransferase, thioredoxin-like domain 4 [IPR040525]", "UGGT, thioredoxin-like domain 1 [IPR040693]", "UGGT, thioredoxin-like domain 2 [IPR040694]", "UGGT, thioredoxin-like domain 3 [IPR040692]", "UHRF1, tandem tudor domain [IPR021991]", "UNC-45/Cro1/She4, central domain [IPR024660]", "UPF0113, PUA domain [IPR005155]", "UPF0113, pre-PUA domain [IPR040598]", "UPF3 domain [IPR005120]", "UPF3B, RNA recognition motif-like domain [IPR034979]", "USP8 dimerisation domain [IPR015063]", "UVR domain [IPR001943]", "Ubiquitin E2 variant, N-terminal [IPR008883]", "Ubiquitin carboxyl-terminal hydrolase 47, C-terminal [IPR045578]", "Ubiquitin carboxyl-terminal hydrolase 5, UBA1 domain [IPR041812]", "Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain [IPR024729]", "Ubiquitin carboxyl-terminal hydrolase, C-terminal [IPR029346]", "Ubiquitin conjugation factor E4, core [IPR019474]", "Ubiquitin specific protease domain [IPR028889]", "Ubiquitin system component CUE [IPR003892]", "Ubiquitin-activating enzyme E1, C-terminal [IPR018965]", "Ubiquitin-activating enzyme E1, FCCH domain [IPR032418]", "Ubiquitin-activating enzyme E1, four-helix bundle [IPR032420]", "Ubiquitin-activating enzyme, SCCH domain [IPR019572]", "Ubiquitin-associated domain [IPR015940]", "Ubiquitin-conjugating enzyme E2 [IPR000608]", "Ubiquitin-like domain [IPR000626]", "Ubiquitin-specific peptidase 48 [IPR033841]", "Ubiquitin-specific-processing protease 48, Ubl domain [IPR044743]", "Ubiquitin/SUMO-activating enzyme ubiquitin-like domain [IPR028077]", "Ubiquitinyl hydrolase, variant UBP zinc finger [IPR041432]", "Ubiquitinyl hydrolase-L5 [IPR033837]", "Ulp1 protease family, C-terminal catalytic domain [IPR003653]", "Uncharacterised domain CHP00451 [IPR004521]", "Uncharacterised domain NUC173 [IPR012978]", "Uncharacterised domain NUC202 [IPR012980]", "Uracil-DNA glycosylase-like [IPR005122]", "Uroporphyrinogen decarboxylase (URO-D) [IPR000257]", "Uso1/p115-like vesicle tethering protein, C-terminal [IPR006955]", "VASP tetramerisation [IPR014885]", "VHS domain [IPR002014]", "VIP36, lectin domain [IPR035664]", "VPS10 [IPR006581]", "VPS13, repeated coiled region [IPR031642]", "VPS9 domain [IPR003123]", "Vacuolar protein sorting-associated protein 13, C-terminal [IPR031645]", "Vacuolar protein sorting-associated protein 13, SHR-binding domain [IPR009543]", "Vacuolar protein sorting-associated protein 13, second N-terminal domain [IPR031646]", "Vacuolar protein sorting-associated protein 13-like, N-terminal domain [IPR026854]", "Vacuolar protein sorting-associated protein 4, MIT domain [IPR045253]", "Valyl tRNA synthetase, anticodon-binding domain [IPR033705]", "Vertebrate SNX3, PX domain [IPR042137]", "Vertebrate ubiquitin-conjugating enzyme E2 K, UBA domain [IPR042599]", "Vesicle tethering protein Uso1/P115-like , head domain [IPR006953]", "Vicinal oxygen chelate (VOC) domain [IPR037523]", "Vinculin-binding site-containing domain [IPR015009]", "Virilizer, N-terminal [IPR031801]", "Vitamin B12-dependent methionine synthase, activation domain [IPR004223]", "Vps16, C-terminal [IPR006925]", "Vps16, N-terminal [IPR006926]", "Vps4 oligomerisation, C-terminal [IPR015415]", "Vps53-like, N-terminal [IPR007234]", "W2 domain [IPR003307]", "WAPL domain [IPR012502]", "WD repeat-containing protein 18, C-terminal domain [IPR026987]", "WGR domain [IPR008893]", "WH1/EVH1 domain [IPR000697]", "WH2 domain [IPR003124]", "WHEP-TRS domain [IPR000738]", "WHIM1 domain [IPR028942]", "WHIM2 domain [IPR028941]", "WSTF/Acf1/Cbp146 [IPR013136]", "WW domain [IPR001202]", "WWE domain [IPR004170]", "Wings apart-like protein, C-terminal [IPR022771]", "Wolframin, EF-hand domain [IPR045460]", "Wolframin, OB-fold domain [IPR045461]", "Wolframin, cysteine-rich domain [IPR045400]", "XPC-binding domain [IPR015360]", "XPG, N-terminal [IPR006085]", "XPG-I domain [IPR006086]", "XRCC1, first (central) BRCT domain [IPR045080]", "Xrn1, helical domain [IPR041412]", "YKT6, SNARE motif [IPR045848]", "YTH domain [IPR007275]", "YchF, C-terminal domain [IPR013029]", "YchF, N-terminal [IPR041706]", "YjeF N-terminal domain [IPR004443]", "YqgF/RNase H-like domain [IPR006641]", "Z-binding domain [IPR042371]", "ZAP, helix turn helix N-terminal domain [IPR041360]", "ZAP, zinc finger [IPR040954]", "ZC3H15/TMA46 family, C-terminal [IPR032378]", "ZO-1, SH3 domain [IPR035597]", "ZO-2, SH3 domain [IPR035598]", "ZU5 domain [IPR000906]", "Zasp-like motif [IPR006643]", "Zinc finger C2H2 AKAP95-type [IPR034736]", "Zinc finger C2H2-type [IPR013087]", "Zinc finger C2HC RNF-type [IPR034734]", "Zinc finger, C2H2, LYAR-type [IPR014898]", "Zinc finger, C3HC-like [IPR012935]", "Zinc finger, C3HC4 RING-type [IPR018957]", "Zinc finger, CCCH-type [IPR000571]", "Zinc finger, CCHC-type [IPR001878]", "Zinc finger, CHHC-type [IPR012996]", "Zinc finger, CW-type [IPR011124]", "Zinc finger, CXXC-type [IPR002857]", "Zinc finger, ClpX C4-type [IPR010603]", "Zinc finger, FCS-type [IPR012313]", "Zinc finger, FPG/IleRS-type [IPR010663]", "Zinc finger, FYVE-related [IPR017455]", "Zinc finger, GATA-type [IPR000679]", "Zinc finger, LIM-type [IPR001781]", "Zinc finger, MIZ-type [IPR004181]", "Zinc finger, MYM-type [IPR010507]", "Zinc finger, MYND-type [IPR002893]", "Zinc finger, PARP-type [IPR001510]", "Zinc finger, PHD-finger [IPR019787]", "Zinc finger, PHD-type [IPR001965]", "Zinc finger, RING-CH-type [IPR011016]", "Zinc finger, RING-type [IPR001841]", "Zinc finger, RanBP2-type [IPR001876]", "Zinc finger, Sec23/Sec24-type [IPR006895]", "Zinc finger, TFIIB-type [IPR013137]", "Zinc finger, TFIIS-type [IPR001222]", "Zinc finger, UBP-type [IPR001607]", "Zinc finger, UBR-type [IPR003126]", "Zinc finger, ZZ-type [IPR000433]", "Zinc finger, double-stranded RNA binding [IPR022755]", "Zinc knuckle CX2CX3GHX4C [IPR025829]", "Zinc ribbon, NADH pyrophosphatase [IPR015376]", "Zinc-finger C2H2-type 11 [IPR041697]", "Zinc-ribbon domain [IPR026870]", "Zn-dependent metallo-hydrolase, RNA specificity domain [IPR011108]", "cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117]", "dUTPase, trimeric [IPR033704]", "dUTPase-like [IPR029054]", "eIF3 subunit M, C-terminal helix domain [IPR040750]", "eIF3B, RNA recognition motif [IPR034363]", "eIF3G, RNA recognition motif [IPR034240]", "eIF3h, C-terminal [IPR045810]", "eIF4H, RNA recognition motif [IPR034229]", "eRF1 domain 1/Pelota-like [IPR005140]", "eRF1 domain 2 [IPR005141]", "eRF1 domain 3 [IPR005142]", "hnRNP A0, RNA recognition motif 1 [IPR034801]", "hnRNP A1, RNA recognition motif 1 [IPR034845]", "hnRNP A1, RNA recognition motif 2 [IPR034803]", "hnRNP A2/B1, RNA recognition motif 1 [IPR034486]", "hnRNP A3, RNA recognition motif 1 [IPR034513]", "hnRNP A3, RNA recognition motif 2 [IPR034516]", "hnRNP DL, RNA recognition motif 1 [IPR034847]", "hnRNP-L, RNA recognition motif 1 [IPR035005]", "hnRNP-L, RNA recognition motif 2 [IPR035008]", "hnRNP-L, RNA recognition motif 3 [IPR034816]", "hnRNP-L, RNA recognition motif 4 [IPR034817]", "hnRNPAB, RNA recognition motif 1 [IPR034846]", "hnRNPH3, RNA recognition motif 2 [IPR034970]", "hnRNPH3, RNA recognition motif 3 [IPR034969]", "hnRNPM, RNA recognition motif 3 [IPR034990]", "hnRPLL, RNA recognition motif 1 [IPR034985]", "hnRPLL, RNA recognition motif 2 [IPR034986]", "hnRPLL, RNA recognition motif 3 [IPR034983]", "hnRPLL, RNA recognition motif 4 [IPR034987]", "mRNA splicing factor Cwf21 domain [IPR013170]", "p21 activated kinase binding domain [IPR033923]", "p21-activated kinase 2, catalytic domain [IPR035064]", "p53 transactivation domain [IPR013872]", "p53, DNA-binding domain [IPR011615]", "p53, tetramerisation domain [IPR010991]", "p54nrb, RNA recognition motif 1 [IPR034552]", "rRNA-processing arch domain [IPR025696]", "snRNP70, RNA recognition motif [IPR034143]", "tRNA methyltransferase TRM10-type domain [IPR028564]", "tRNA methyltransferase TRMD/TRM10-type domain [IPR016009]", "tRNA nucleotidyltransferase/poly(A) polymerase, RNA and SrmB- binding domain [IPR032828]", "tRNA pseudouridylate synthase B, C-terminal [IPR032819]", "tRNA synthetase, B5-domain [IPR005147]", "tRNA synthetases class I, catalytic domain [IPR032678]", "tRNA(Met) cytidine acetyltransferase TmcA, N-terminal [IPR013562]", "tRNA-binding domain [IPR002547]", "tRNAHis guanylyltransferase catalytic domain [IPR024956]", "tRNase Z endonuclease [IPR027794]", "v-SNARE, coiled-coil homology domain [IPR042855]", "von Willebrand factor, type A [IPR002035]"], "available_proteins": ["AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABHD10", "ABHD12", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN4", "ADAM17", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADRM1", "ADSL", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK2", "AKAP1", "AKAP12", "AKAP13", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC5", "ANK3", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "APLP2", "APMAP", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARMCX3", "ARMT1", "ASAH1", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "ATP6V1H", "ATXN10", "ATXN2L", "AUP1", "BAG6", "BAIAP2", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BIRC6", "BLM", "BLVRA", "BMS1", "BOP1", "BPTF", "BRCA1", "BRD2", "BRIX1", "BROX", "BSG", "BTF3", "BUB1B", "BUD23", "BZW1", "C1orf35", "CACYBP", "CAD", "CALU", "CAMK2D", "CAMK2G", "CAND1", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CARM1", "CARS", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC97", "CD2AP", "CDC23", "CDC34", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CEBPZ", "CECR2", "CELF1", "CENPB", "CEP170", "CERS2", "CFAP20", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHD4", "CHERP", "CHID1", "CHORDC1", "CHRAC1", "CHTF18", "CIAPIN1", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLIC1", "CLINT1", "CLPB", "CLPX", "CLTC", "CLUH", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT3", "CNOT6", "CNPY2", "COA3", "COIL", "COMMD2", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "CORO1B", "CORO1C", "COTL1", "COX2", "COX6C", "CPD", "CPNE1", "CPNE3", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CRKL", "CRYZ", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNBL1", "CTPS1", "CTPS2", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CWF19L1", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYFIP1", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF13", "DCTN1", "DDB1", "DDI2", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DFFA", "DGCR8", "DGUOK", "DHCR24", "DHFR", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIAPH1", "DIAPH3", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNTTIP2", "DOCK7", "DPF2", "DPM1", "DPP9", "DPYSL2", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "ECE1", "ECI2", "ECSIT", "EDC3", "EDC4", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B3", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "EMC1", "EMC7", "EMD", "EML4", "ENAH", "ENO1", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERLIN2", "ERP29", "ERP44", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOSC1", "EXOSC10", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM208A", "FAM49B", "FAM8A1", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FDFT1", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FOXC1", "FOXK1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GARS", "GART", "GATAD2A", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GIGYF2", "GINS4", "GLA", "GLB1", "GLDC", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMPPA", "GMPS", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGB1", "GORASP2", "GOT1", "GOT2", "GPATCH4", "GPD2", "GPI", "GPRASP2", "GPS1", "GRB2", "GRHPR", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF3C1", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDLBP", "HEATR1", "HECTD1", "HELLS", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIC2", "HIF1AN", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOXA10", "HP1BP3", "HPRT1", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA4", "HSPA4L", "HSPB1", "HSPBP1", "HSPH1", "HTRA2", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFT27", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMPDH2", "INA", "INCENP", "INF2", "INTS11", "INTS14", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRGQ", "IRS4", "ISOC1", "ISYNA1", "ITCH", "ITGB1", "IVD", "KARS", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0391", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMTOR2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3BP", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC47", "LSM12", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LYAR", "LYPLA1", "MACF1", "MAGED2", "MAK16", "MAP2K1", "MAPRE1", "MAPRE2", "MARC1", "MARK2", "MARS", "MAT2A", "MATR3", "MBD3", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "METAP2", "METTL13", "MFN1", "MFN2", "MIA3", "MICU1", "MICU2", "MID1", "MINDY3", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOGS", "MORF4L1", "MOV10", "MPP2", "MPP6", "MPRIP", "MPST", "MRE11", "MRPL11", "MRPL12", "MRPL15", "MRPL2", "MRPL24", "MRPL39", "MRPL44", "MRPL45", "MRPL46", "MRPL48", "MRPL58", "MRPL9", "MRPS23", "MRPS25", "MRPS35", "MRPS5", "MRPS7", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MTA1", "MTA2", "MTAP", "MTBP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MTX3", "MYEF2", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAA40", "NAA50", "NAGK", "NAGLU", "NAMPT", "NANS", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPG", "NCBP1", "NCL", "NCLN", "NCSTN", "NDUFA10", "NDUFA9", "NDUFAF1", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NEMF", "NENF", "NES", "NEU1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC3L", "NOC4L", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NPTN", "NRBP1", "NRDC", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NTPCR", "NUB1", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP35", "NUP50", "NUP54", "NUP62", "NUP98", "NUPL2", "NUTF2", "NVL", "NXF1", "OCIAD1", "OCLN", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OSBP", "OSBPL11", "OSBPL6", "OSBPL9", "OTUB1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARN", "PARP1", "PARP2", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCM1", "PCNA", "PCYOX1", "PDCD11", "PDCD4", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFKL", "PFKM", "PFKP", "PGD", "PGLS", "PGM1", "PGM2", "PGM3", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF6", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIN4", "PIR", "PITHD1", "PITRM1", "PKM", "PKN2", "PLAA", "PLD3", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POP1", "POR", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1R10", "PPP5C", "PQBP1", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREP", "PREPL", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSPC1", "PTBP1", "PTCD1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPN1", "PUF60", "PUM3", "PUS1", "PUS7", "PWP2", "PYCR1", "PYCR2", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RABGGTA", "RAC1", "RAD21", "RAD23B", "RAD50", "RAD51AP1", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM34", "RBM39", "RBM4", "RBM45", "RBM5", "RBM8A", "RBMX", "RCL1", "RCN1", "RCN2", "RCOR1", "RDX", "RECQL", "RECQL5", "REPS1", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIF1", "RIOK2", "RIPK1", "RNASEH2A", "RNF114", "RNF20", "RNF40", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPAP3", "RPF2", "RPL10", "RPL11", "RPL12", "RPL14", "RPL18", "RPL18A", "RPL19", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL30", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPRD1A", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS2", "RPS20", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS9", "RPSA", "RRBP1", "RRM1", "RRP12", "RRP7A", "RSF1", "RTN3", "RTN4", "RTN4IP1", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAR1A", "SARNP", "SARS", "SARS2", "SART3", "SBDS", "SCAF8", "SCCPDH", "SCP2", "SCRIB", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEL1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGTA", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SIN3A", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC18B1", "SLC25A12", "SLC25A13", "SLC25A24", "SLC27A4", "SLC3A2", "SLC6A15", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMU1", "SMYD3", "SNAP29", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX2", "SNX3", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPEN", "SPTAN1", "SPTBN1", "SPTLC1", "SQLE", "SQSTM1", "SRCAP", "SRI", "SRM", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSRP1", "STAG2", "STARD3", "STAT3", "STAU1", "STAU2", "STEAP3", "STIP1", "STOML2", "STRBP", "STRN4", "STUB1", "STX12", "STX18", "STX7", "STX8", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TAF15", "TAGLN2", "TAP1", "TAP2", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCE", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TDP2", "TDRKH", "TECR", "TELO2", "TEX10", "TFAM", "TFG", "TFRC", "THG1L", "THOC1", "THOC2", "THOC3", "THOP1", "THUMPD3", "TIA1", "TIAL1", "TIMELESS", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TKT", "TLN1", "TMED10", "TMED7", "TMED9", "TMEM201", "TMEM205", "TMEM97", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX4", "TNKS1BP1", "TNPO1", "TOE1", "TOLLIP", "TOM1", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOX4", "TP53", "TP53BP1", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRNT1", "TROVE2", "TSC2", "TSFM", "TSG101", "TSR1", "TSTA3", "TTC4", "TTK", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBL5", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UCHL5", "UGDH", "UGGT1", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF3B", "UQCRC1", "UQCRC2", "UROD", "USO1", "USP10", "USP14", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP20", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VCP", "VIM", "VIRMA", "VPS13A", "VPS16", "VPS18", "VPS29", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WDHD1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR43", "WDR46", "WFS1", "WIZ", "XPNPEP1", "XPO1", "XPO5", "XPO7", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YBX1", "YKT6", "YME1L1", "YTHDC1", "YTHDC2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBTB10", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZDHHC20", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZNF148", "ZNF281", "ZNF318", "ZNF326", "ZNF638", "ZNF687", "ZRANB2", "ZYX"], "leading_proteins": ["ABCB1", "ACADS", "ACBD3", "ACOT7", "AKAP8L", "ALDH1A2", "ALDH1B1", "ALDH3A2", "ALYREF", "ANK3", "ANKLE2", "ANP32B", "AUP1", "BAIAP2", "BRCA1", "CALU", "CAPN2", "CBX1", "CBX3", "CENPB", "CERS2", "CIRBP", "CNOT6", "COPS4", "COPS8", "COPZ1", "CPSF6", "CSE1L", "CSTF2", "CTDSPL2", "CYB5B", "CYB5D2", "CYB5R1", "DAZAP1", "DHCR24", "DNAJC10", "DNAJC2", "DNAJC3", "DNAJC8", "DNAJC9", "DNM1L", "DUSP3", "DUSP9", "EEF1B2", "EIF3E", "EIF3M", "EIF4H", "ELOA", "EPHA7", "EWSR1", "F11R", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP7", "FMR1", "FUBP1", "FUS", "FXR1", "GALNT1", "GM2A", "GMPPA", "GRSF1", "HADH", "HDGF", "HDGFL2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPLL", "HNRNPR", "HSDL2", "IDH2", "IPO8", "KDM2A", "KMT2A", "LEMD3", "LMAN2", "LMNB1", "LMNB2", "LNPEP", "MAPRE2", "MFN1", "MID1", "MPP2", "MPP6", "MRTO4", "MSN", "MTX1", "MYL6", "NECAP2", "NOL8", "NONO", "NPEPPS", "NRDC", "NSD2", "NSFL1C", "NUCB1", "NUCB2", "OPA1", "P4HA2", "PAK4", "PDE12", "PDLIM5", "PGLS", "PHC2", "PICALM", "PITHD1", "POR", "PPAN", "PRDX2", "PRDX3", "PRDX6", "PRPF19", "PRPF3", "PSMD8", "PSME2", "PSPC1", "PTBP1", "PTGES2", "PUF60", "RAD23B", "RAVER1", "RBM10", "RBM14", "RBM17", "RBM22", "RBM25", "RBM26", "RBM27", "RBM4", "RBM5", "RBM8A", "RBMX", "RCN2", "RDX", "RHOT2", "RNF20", "RP2", "RPF2", "RPS20", "RTN3", "RTN4IP1", "SAMHD1", "SCP2", "SDF4", "SEC16A", "SFPQ", "SHMT2", "SLC25A24", "SNAP29", "SQSTM1", "SRI", "SRSF1", "SRSF10", "SRSF3", "SRSF9", "STAU1", "STX12", "STX8", "SUPT6H", "SYNCRIP", "SYNGR2", "TAF15", "TDP2", "THOC1", "TIA1", "TIAL1", "TMED10", "TMED7", "TOE1", "TRA2B", "TRIM26", "TRIM28", "TRIM33", "TUBB", "TUBB4B", "TUBB6", "U2AF2", "UBQLN4", "UQCRC1", "UQCRC2", "VIM", "YWHAG", "YWHAH", "YWHAQ", "ZADH2", "ZC3H7A"]} \ No newline at end of file diff --git a/interpro_family/advanced/idx2term.json b/interpro_family/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..cf1055ec529245b750ed79c477a9951fd7878bb0 --- /dev/null +++ b/interpro_family/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Proteasome, subunit alpha/beta [IPR001353]", "1": "Proteasome B-type subunit [IPR023333]"} \ No newline at end of file diff --git a/interpro_family/advanced/plot_0.png b/interpro_family/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..51eeab3b8242ecb88fb3866ba270e4d4bad4ed51 --- /dev/null +++ b/interpro_family/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:af0f6d9b5dd6d6ec5f3204e3c77ae82da66d7e897b96df35c2147b4bd56c36d6 +size 188600 diff --git a/interpro_family/advanced/plot_1.png b/interpro_family/advanced/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..ca0a5a8de0aa41e900f8360ad738176a46d5024e --- /dev/null +++ b/interpro_family/advanced/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:8b5ea8654bc9b04a4f05c34fb0d80de7217ce7ea8a41afbc74c2f7d754d0c4fe +size 180393 diff --git a/interpro_family/basic/idx2term.json b/interpro_family/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..eb5f9b5ee8bd556b1d647ca91e471f46ae326cc6 --- /dev/null +++ b/interpro_family/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Proteasome, subunit alpha/beta [IPR001353]", "1": "Proteasome B-type subunit [IPR023333]", "2": "Mitochondrial carrier protein [IPR002067]", "3": "Small GTPase [IPR001806]"} \ No newline at end of file diff --git a/interpro_family/basic/plot_0.png b/interpro_family/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..61ba6e0169bfbe80677c10bd352efb1570da6909 --- /dev/null +++ b/interpro_family/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:f407e436ea853ebf121cf397c5d8efc0cca4e801b9cb835194d10903e34630a3 +size 144757 diff --git a/interpro_family/basic/plot_1.png b/interpro_family/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..6ea66541122dca1ae701602cf1f03cea408a8657 --- /dev/null +++ b/interpro_family/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:87c003336ffb7f1f530ae012e76cb17f38697ef7fe5003be9e1eb0fbcbf32797 +size 135329 diff --git a/interpro_family/basic/plot_2.png b/interpro_family/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..da7ba2ad3b7aabc0ba151ecd720ce2ad6fda24a6 --- /dev/null +++ b/interpro_family/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:d148c7110c8b5faf56e5f2172f491bb1010282beeffe7de7205dfeddb836679d +size 132074 diff --git a/interpro_family/basic/plot_3.png b/interpro_family/basic/plot_3.png new file mode 100644 index 0000000000000000000000000000000000000000..00969c18e86caee1603dd6ba5826b0cd81251aec --- /dev/null +++ b/interpro_family/basic/plot_3.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:975a7410997720c83e532e37fca31b371a3c8a65054a4ce8d03dda7654e33680 +size 143226 diff --git a/interpro_family/consensus.joblib b/interpro_family/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..a2f7649051b9461a4b4e080afcc67ab918c224b7 --- /dev/null +++ b/interpro_family/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:b6ae1b7f7f1ff4535e3ed1c8f7fa77df1aa1ad45ea0034c273883226cbfe102c +size 387626 diff --git a/interpro_family/df_merge.tsv b/interpro_family/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..258f1233b7cf676a50389fcbde8857f4f432c356 --- /dev/null +++ b/interpro_family/df_merge.tsv @@ -0,0 +1,4 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Proteasome, subunit alpha/beta [IPR001353] 6 14 2.904972243201195 0.0036728567008292 5.075242718446602 13.970873786407768 1.2284854682369022 0.3020132543529001 2.3027355385508845 0.1681602725795027 1.1101966392985694 0.3179790146746512 1.0 0.0742352733278267 0.0102498345034834 2.7582058036655703e-05 4.444471381104669e-06 +Proteasome B-type subunit [IPR023333] 5 7 2.3269246462379427 0.0199692761892675 3.699029126213592 6.970873786407767 1.6670727234653664 0.1509307531330224 1.4503762582219135 0.1681602725795027 0.9611878160538336 0.233503072382129 1.0 0.0424464003246627 0.0032139762811053 3.788095303003865e-05 8.872830475208381e-07 +Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930] 2 6 2.0476699020294555 0.0405923549015689 2.121359223300971 5.466019417475728 1.4317001483019938 0.1783942022754649 1.021530403905949 0.5881604361499402 0.986353205880356 0.2226891741813114 1.0 0.0378187125466048 4.800413077288208e-05 0.0007102815399137 0.0003159986655096 diff --git a/interpro_family/metrics.json b/interpro_family/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..87952d9686e51d168b62f1d550fe41ce3d7ba19f --- /dev/null +++ b/interpro_family/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2454, + "annotations_size": 1958, + "title": "Average number of proteins per term", + "value": 1.2584269662921348 +} \ No newline at end of file diff --git a/interpro_family/paths.json b/interpro_family/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..218b444e261d50dea45f05dc06757188382704a1 --- /dev/null +++ b/interpro_family/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_family/fragment/C340/C340_val_log2fc"} \ No newline at end of file diff --git a/interpro_family/result.tsv b/interpro_family/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..1eea95d4a2a62962191b845486c32f16ce8d6201 --- /dev/null +++ b/interpro_family/result.tsv @@ -0,0 +1,76 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Proteasome, subunit alpha/beta [IPR001353] 0.8064897327358946 2.904972243201195 0.0036728567008292 0.9992569092909042 0.0472065482393559 14 P28070,P28072,P20618,P49721,P60900,Q99436 6 +Proteasome B-type subunit [IPR023333] 0.8630343481895583 2.3269246462379427 0.0199692761892675 1.0 0.0749039133689385 7 P28070,P28072,P20618,P49721,Q99436 5 +Tubulin [IPR000217] 0.9726530612244896 2.317108644920705 0.0204978142125638 1.0 0.076156964379886 4 Q9BUF5,P07437,P68371 3 +Beta tubulin [IPR002453] 0.9726530612244896 2.317108644920705 0.0204978142125638 1.0 0.076156964379886 4 Q9BUF5,P07437,P68371 3 +Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678] 0.9955138662316476 2.2562662087550547 0.0240539642911794 1.0 0.0818443997521306 2 O60830 1 +Haem oxygenase [IPR002051] 0.991435562805872 2.2395010215982603 0.0251233349237796 1.0 0.0832343312703222 2 P30519 1 +Haem oxygenase-like [IPR016053] 0.991435562805872 2.2395010215982603 0.0251233349237796 1.0 0.0832343312703222 2 P30519 1 +Nucleobindin [IPR040250] 0.9865415986949422 2.2193515102081456 0.0264628197905196 1.0 0.0856433076856818 2 P80303 1 +Aminopeptidase N-type [IPR034016] 0.944639847254494 2.208493834385211 0.0272098671403557 1.0 0.0869117779132408 4 Q9UIQ6,P55786 2 +Isocitrate dehydrogenase NADP-dependent [IPR004790] 0.9824632952691674 2.2025343585866346 0.0276275848855775 1.0 0.0873906481517947 2 P48735 1 +CD36 family [IPR002159] 0.9743066884176168 2.1688301319916365 0.0300955827046567 1.0 0.0926527530435815 2 Q8WTV0 1 +Ergosterol biosynthesis ERG4/ERG24 [IPR001171] 0.963295269168024 2.1231837101527073 0.0337384604655155 1.0 0.09904033821811 2 Q14739 1 +ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028] 0.9510603588907004 2.072273521851118 0.0382399402686557 1.0 0.1064502666594156 2 Q93050 1 +V-type ATPase, V0 complex, 116kDa subunit family [IPR002490] 0.9510603588907004 2.072273521851118 0.0382399402686557 1.0 0.1064502666594156 2 Q93050 1 +Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930] 0.8487956553260017 2.0476699020294555 0.0405923549015689 1.0 0.1108169125252862 6 Q9UIQ6,P55786 2 +Mpv17/PMP22 [IPR007248] 0.94086460032626 2.0296983025033355 0.0423872155654043 1.0 0.1134990116160808 2 Q567V2 1 +Prolyl 4-hydroxylase [IPR045054] 0.9282218597063596 1.9767220324643264 0.0480730589506812 1.0 0.1211416337521671 2 O15460 1 +Eukaryotic porin/Tom40 [IPR027246] 0.8668971632003581 1.9007729842365364 0.0573317541155944 1.0 0.1377369012985692 4 P21796 1 +Transmembrane protein GPR107/GPR108-like [IPR009637] 0.9070146818923268 1.8874272356065016 0.0591028847453987 1.0 0.1409202473855931 2 Q5VW38 1 +Mitochondrial carrier UCP-like [IPR002030] 0.8976345840130443 1.847769719462736 0.0646356631641551 1.0 0.1485448186448271 2 Q9H2D1 1 +Peptidase S10, serine carboxypeptidase [IPR001563] 0.9673602611179124 1.831329934829985 0.0670513121898026 1.0 0.1517762650492873 3 Q9HB40,Q9H3G5 2 +Mitochondrial carrier protein [IPR002067] 0.6801943515255906 1.738338908982345 0.082151114271346 1.0 0.1715834945888887 8 Q9UJS0,Q9HC21,Q6NUK1,O43808,P12235 5 +TAF15/EWS/TLS family [IPR034870] 0.9420644634842928 1.73451495194823 0.0828267551369634 1.0 0.1724699971560761 3 P35637,Q92804 2 +Mitofusin family [IPR027094] 0.8552202283849897 1.6673827907161785 0.0954383136064214 1.0 0.187996195212649 2 Q8IWA4 1 +Small GTPase superfamily, ARF type [IPR024156] 0.8486949429037527 1.639500344187042 0.1011090990521026 1.0 0.195817622100907 2 P18085 1 +Microtubule-associated protein RP/EB [IPR027328] 0.8417618270799367 1.6098450380566791 0.1074316901858076 1.0 0.203828730023073 2 Q15555 1 +Porin, eukaryotic type [IPR001925] 0.9009996596613834 1.576281992071584 0.1149608298491906 1.0 0.2135495826737448 3 P21796 1 +Ribonuclease CAF1 [IPR006941] 0.8900139811029816 1.5337763410794345 0.125084685308618 1.0 0.2267613912641462 3 Q9UIV1 1 +Transmembrane protein 126 [IPR009801] 0.817292006525276 1.5049840337321174 0.132328181658238 1.0 0.2354599406541894 2 Q9H061 1 +Prefoldin alpha-like [IPR004127] 0.808319738988581 1.4664835553412292 0.1425165980078646 1.0 0.246009088089336 2 Q99471 1 +Peptidase T1A, proteasome beta-subunit [IPR000243] 0.872297021623831 1.4651180605013994 0.1428887100116065 1.0 0.2462540314432355 3 Q99436,P28072 2 +HnRNP R/Q splicing factor [IPR006535] 0.8058727569331184 1.455980892087177 0.1453979018861548 1.0 0.2495084065671264 2 O60506 1 +Profilin [IPR005455] 0.7993474714518656 1.4279710796467522 0.1533001828542315 1.0 0.2589833977813506 2 P07737 1 +Profilin1/2/3, vertebrate [IPR005454] 0.7993474714518656 1.4279710796467522 0.1533001828542315 1.0 0.2589833977813506 2 P07737 1 +G-protein alpha subunit, group I [IPR001408] 0.7777324632952722 1.335210595282506 0.1818074300784689 1.0 0.2913084681617365 2 P04899 1 +14-3-3 protein [IPR000308] 0.6347601898743878 1.1426666095990483 0.2531770382339848 1.0 0.3613082311673593 6 P61981,P27348,Q04917 3 +RNA-binding protein 26/27 [IPR045137] 0.7296084828711263 1.1296300882051329 0.258632127199095 1.0 0.3660329543095851 2 Q9P2N5 1 +Snf7 family [IPR005024] 0.7141109298531847 1.064030147362307 0.2873150426825583 1.0 0.392303245169072 2 Q8WUX9 1 +A-kinase anchoring protein 95 (AKAP95) [IPR007071] 0.7120717781402975 1.055431335949665 0.29122809764737 1.0 0.3954400937541959 2 Q9ULX6 1 +Short-chain dehydrogenase/reductase SDR [IPR002347] 0.4746332672194224 1.0370671636187547 0.2997045570658878 1.0 0.4015878087968158 13 Q3SXM5,Q8NBN7,Q06136,P35270 4 +Glutathione Transferase family [IPR040079] 0.5352193317019664 1.0368291553369755 0.2998154852914121 1.0 0.4015878087968158 8 Q13505,Q9H7Z7 2 +Small GTPase [IPR001806] 0.410972724440345 0.9789544804834636 0.3276024713245007 1.0 0.4251587473305498 24 Q969Q5,P61020,P62820,P11233,Q9BW83,Q3YEC7 6 +CPSF6/7 family [IPR034772] 0.682707993474707 0.9326927192052088 0.3509786451552645 1.0 0.44521468960967 2 Q16630 1 +Vacuolar protein sorting-associated protein 33 [IPR027121] 0.6802610114192518 0.9225720063890502 0.3562302895704048 1.0 0.4492163246489071 2 Q96AX1 1 +Fragile X mental retardation syndrome-related protein [IPR040148] 0.7095063239494073 0.8406258604223189 0.4005575665772056 1.0 0.4890453217314586 3 P51114,Q06787 2 +Nucleosome assembly protein (NAP) [IPR002164] 0.7037943696450512 0.8195104485487047 0.412495243109745 1.0 0.4993798090985702 3 Q01105,P55209 2 +Annexin [IPR001464] 0.5712647991307751 0.791453646671129 0.4286793152489159 1.0 0.5121135443913223 5 P20073,P04083,P50995 3 +Transmembrane emp24 domain-containing protein [IPR015720] 0.6919624643002876 0.7761151834660455 0.4376809794423688 1.0 0.5186027495130032 3 Q9Y3B3,P49755 2 +Small GTPase superfamily, ARF/SAR type [IPR006689] 0.5579837854816598 0.7372387374400469 0.460977180082053 1.0 0.5356636905641898 5 P40616,P18085 2 +Actin-related protein 2/3 complex subunit 1 [IPR017383] 0.6309135399673756 0.7234564982674133 0.4693994710675331 1.0 0.5416297335284583 2 Q92747 1 +Guanine nucleotide binding protein (G-protein), alpha subunit [IPR001019] 0.6771062613093392 0.7223634154826346 0.470071073432708 1.0 0.5416297335284583 3 P04899 1 +Mitochondrial Rho GTPase [IPR021181] 0.6211256117455195 0.6853804047367859 0.4931039059249764 1.0 0.5587369489589722 2 Q8IXI1 1 +ADP/ATP carrier protein, eukaryotic type [IPR002113] 0.6658714110377577 0.6823304677398914 0.4950300117278075 1.0 0.5593010749931027 3 P12235 1 +Peptidase C2, calpain family [IPR022684] 0.619086460032632 0.6775200537153125 0.4980760508708892 1.0 0.5614466940732303 2 P17655 1 +Prohibitin [IPR000163] 0.5938009787928237 0.5823722571000661 0.5603159643187638 1.0 0.6084851126656349 2 P35232 1 +Serine hydroxymethyltransferase [IPR001085] 0.5469004893964198 0.4199294669115569 0.6745369806684534 1.0 0.6999170154471815 2 P34897 1 +Prenylated rab acceptor PRA1 [IPR004895] 0.5326264274062044 0.3749496827260881 0.7076978884768188 1.0 0.7312255755343595 2 O60831 1 +Heterogeneous nuclear ribonucleoprotein C [IPR017347] 0.5195758564437285 0.3359397172520815 0.7369163257414633 1.0 0.7586131260787514 2 P07910 1 +Syntaxin [IPR045242] 0.5372843674743434 0.2834356636412116 0.7768428931244891 1.0 0.7959593437349293 3 Q9UNK0 1 +Prefoldin beta-like [IPR002777] 0.4991843393148482 0.279363037483271 0.7799662340949358 1.0 0.7987311121118642 2 Q9UHV9 1 +HnRNP-L/PTB [IPR006536] 0.5303957568339488 0.2662854603523814 0.7900193699443316 1.0 0.8077587082772852 3 Q8WVV9,P26599 2 +Proteasome activator PA28 [IPR009077] 0.5273289556283682 0.2588222087647908 0.7957724214885944 1.0 0.8129253924252212 3 Q9UL46 1 +Peroxiredoxin, AhpC-type [IPR024706] 0.4828711256117546 0.2382125910767575 0.8117162119108603 1.0 0.8277814286049294 2 P32119 1 +Dynamin [IPR022812] 0.5099959200326435 0.2186946807741671 0.8268878928223689 1.0 0.8423759074642031 3 O00429,O60313 2 +Sodium/potassium-transporting ATPase subunit beta [IPR000402] 0.4628874388254634 0.1930734901046376 0.8469014138482109 1.0 0.8605256711545392 2 P54709 1 +Calreticulin/calnexin [IPR001580] 0.4802121583027315 0.1582512317858274 0.8742588351992797 1.0 0.8860242232506158 3 O14967,P27797 2 +Adenylate kinase/UMP-CMP kinase [IPR000850] 0.4798041615667128 0.1575001334127116 0.8748507027580397 1.0 0.8861653781687748 3 P00568,P54819 2 +Ribosomal protein L10P [IPR001790] 0.4626682986536047 0.1278564753717123 0.8982625558855957 1.0 0.9084700849297502 3 Q9UKD2,Q7Z7H8 2 +Ribosomal protein S2 [IPR001865] 0.3911092985318211 0.0800987456663184 0.9361587203572472 1.0 0.9441110433661232 2 P08865 1 +ABC transporter Tap-like [IPR013305] 0.376835236541598 0.0662671272616936 0.9471651543221644 1.0 0.9534958211633924 2 Q03519 1 +Ezrin/radixin/moesin [IPR011174] 0.4010607915136749 0.0512165369805654 0.9591529745335116 1.0 0.9640767577703367 3 P26038,P35241 2 +Actin family [IPR004000] 0.3288239375983738 0.0503814177488855 0.959818444067335 1.0 0.9642506482728792 6 P61163,O96019 2 +E3 ubiquitin ligase Bre1 [IPR013956] 0.3136215334420895 0.0310872688870848 0.9751999427199364 1.0 0.9786988661433292 2 Q5VTR2 1 +NudC family [IPR037898] 0.3062805872756884 0.0290828444232227 0.9767985181779124 1.0 0.9798009726395248 2 Q9Y266 1 +Sec1-like protein [IPR001619] 0.3155102040816291 0.0232743885361727 0.981431401166208 1.0 0.983944026361206 4 Q8WVM8,Q96AX1,Q9H267 3 diff --git a/interpro_family/selections.json b/interpro_family/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..b0cbae342f4f646b9fd38aa26ed853222e6924ef --- /dev/null +++ b/interpro_family/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["-alpha-acetyltransferase 35, NatC auxiliary subunit [IPR007244]", "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, eukaryotes [IPR027496]", "1-Cys peroxiredoxin [IPR045020]", "14-3-3 protein [IPR000308]", "14-3-3 theta [IPR042584]", "18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23-like [IPR039769]", "2-amino-3-ketobutyrate coenzyme A ligase [IPR011282]", "2-deoxynucleoside 5-phosphate N-hydrolase 1, DNPH1 [IPR028607]", "2-oxoglutarate dehydrogenase E1 component [IPR011603]", "2-phosphoglycolate phosphatase, eukaryotic [IPR006349]", "26S Proteasome non-ATPase regulatory subunit 1 [IPR035266]", "26S Proteasome non-ATPase regulatory subunit 11 [IPR035295]", "26S Proteasome non-ATPase regulatory subunit 12 [IPR035297]", "26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4 [IPR040134]", "26S Proteasome non-ATPase regulatory subunit 13 [IPR035298]", "26S Proteasome non-ATPase regulatory subunit 14 [IPR035299]", "26S Proteasome non-ATPase regulatory subunit 6 [IPR035268]", "26S Proteasome non-ATPase regulatory subunit 7/8 [IPR033858]", "26S Proteasome regulatory subunit 4 [IPR035244]", "26S Proteasome regulatory subunit 6A [IPR035254]", "26S Proteasome regulatory subunit 6B [IPR035256]", "26S Proteasome regulatory subunit 7 [IPR035245]", "26S proteasome non-ATPase regulatory subunit 10-like [IPR039334]", "26S proteasome non-ATPase regulatory subunit 3 [IPR035267]", "26S proteasome non-ATPase regulatory subunit Rpn12 [IPR006746]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit [IPR016643]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit [IPR016642]", "26S proteasome regulatory subunit 10B [IPR035263]", "26S proteasome regulatory subunit P45-like [IPR005937]", "26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 [IPR019585]", "28S ribosomal protein S25, mitochondrial [IPR040049]", "28S ribosomal protein S27, mitochondrial [IPR019266]", "3'-5' RNA helicase YTHDC2-like [IPR031083]", "3-hydroxyacyl-CoA dehydrogenase [IPR022694]", "3-hydroxyisobutyrate dehydrogenase [IPR011548]", "3-hydroxyisobutyrate dehydrogenase-related [IPR015815]", "3-ketodihydrosphingosine reductase KDSR-like [IPR045022]", "3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase [IPR039357]", "39S ribosomal protein L46, mitochondrial [IPR040008]", "40S Ribosomal protein S10 [IPR037447]", "40S ribosomal protein S1/3, eukaryotes [IPR027500]", "40S ribosomal protein SA [IPR027504]", "4F2 cell-surface antigen heavy chain [IPR042280]", "5'-3' exoribonuclease [IPR027073]", "5'-3' exoribonuclease type 2 [IPR017151]", "5-lipoxygenase-activating protein [IPR001446]", "50S ribosomal protein L18Ae/60S ribosomal protein L20 and L18a [IPR028877]", "6-Phosphogluconolactonase [IPR039104]", "6-phosphogluconate dehydrogenase [IPR006183]", "6-phosphogluconate dehydrogenase, decarboxylating [IPR006113]", "60S acidic ribosomal protein P0 [IPR030670]", "60S ribosomal protein L18a/ L20, eukaryotes [IPR021138]", "60S ribosomal protein L19 [IPR039547]", "60S ribosomal protein L35 [IPR045059]", "60S ribosomal protein L6E [IPR000915]", "60kDa SS-A/Ro ribonucleoprotein [IPR040322]", "A-kinase anchor protein 12 [IPR028540]", "A-kinase anchor protein 13 [IPR028852]", "A-kinase anchor protein 17A [IPR034355]", "A-kinase anchoring protein 95 (AKAP95) [IPR007071]", "AAA ATPase, CDC48 family [IPR005938]", "ABC transporter Tap-like [IPR013305]", "ADF/Cofilin [IPR017904]", "ADP-ribose pyrophosphatase, mitochondrial [IPR039989]", "ADP-ribosylation factor 1-5 [IPR045872]", "ADP-ribosylation factor-like protein 2 [IPR045873]", "ADP-ribosylation factor-like protein 2/3 [IPR044612]", "ADP-ribosylation factor-like protein 6-interacting protein 1 [IPR033301]", "ADP-ribosylation/Crystallin J1 [IPR005502]", "ADP-specific phosphofructokinase/glucokinase [IPR007666]", "ADP/ATP carrier protein, eukaryotic type [IPR002113]", "AH receptor-interacting protein [IPR031208]", "AIP/AIPL1 [IPR039663]", "AP complex subunit beta [IPR026739]", "AP endonuclease 1 [IPR004808]", "AP-1/2/4 complex subunit beta [IPR016342]", "AP-3 complex subunit beta [IPR026740]", "AP-3 complex subunit sigma [IPR027155]", "ATP synthase membrane subunit K [IPR009125]", "ATP synthase, F0 complex, subunit B [IPR013837]", "ATP synthase, F0 complex, subunit B/MI25 [IPR008688]", "ATP synthase, F0 complex, subunit D, mitochondrial [IPR008689]", "ATP synthase, F0 complex, subunit E, mitochondrial [IPR008386]", "ATP synthase, F0 complex, subunit G, mitochondrial [IPR006808]", "ATP synthase, F1 complex, alpha subunit [IPR005294]", "ATP synthase, F1 complex, beta subunit [IPR005722]", "ATP synthase, F1 complex, gamma subunit [IPR000131]", "ATP-binding cassette sub-family C member 4 [IPR030240]", "ATP-citrate synthase [IPR014608]", "ATP-dependent 6-phosphofructokinase [IPR022953]", "ATP-dependent 6-phosphofructokinase, eukaryotic-type [IPR009161]", "ATP-dependent 6-phosphofructokinase, vertebrate-type [IPR041914]", "ATP-dependent Clp protease proteolytic subunit [IPR001907]", "ATP-dependent RNA helicase DHX29 [IPR034730]", "ATP-dependent RNA helicase Ski2-like [IPR016438]", "ATP-dependent helicase Rad3/Chl1-like [IPR013020]", "ATP:cob(I)alamin adenosyltransferase, PduO-type [IPR029499]", "ATP:guanido phosphotransferase [IPR000749]", "ATPase family AAA domain-containing protein 3 [IPR039188]", "ATPase, OSCP/delta subunit [IPR000711]", "ATPase, V0 complex, c/d subunit [IPR002843]", "ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028]", "ATPase, V0 complex, subunit d [IPR016727]", "ATPase, V1 complex, subunit A [IPR005725]", "ATPase, V1 complex, subunit B [IPR005723]", "ATPase, V1 complex, subunit C [IPR004907]", "ATPase, V1 complex, subunit H [IPR004908]", "Acetyl-coenzyme A transporter 1-like [IPR024371]", "Acid ceramidase-like [IPR016699]", "Acidic leucine-rich nuclear phosphoprotein 32 [IPR045081]", "Acireductone dioxygenase ARD family [IPR004313]", "Aconitase, mitochondrial-like [IPR006248]", "Aconitase/Iron-responsive element-binding protein 2 [IPR006249]", "Actin family [IPR004000]", "Actin-related protein 2/3 complex subunit 1 [IPR017383]", "Actin-related protein 2/3 complex subunit 1A [IPR030140]", "Actin-related protein 2/3 complex subunit 1B [IPR030141]", "Actin-related protein 2/3 complex subunit 3 [IPR007204]", "Actin-related protein 2/3 complex subunit 4 [IPR008384]", "Actin-related protein 3 [IPR015623]", "Actin-related protein 6 [IPR030054]", "Activator of 90kDa heat shock protein ATPase-like [IPR039981]", "Activator of Hsp90 ATPase homologue 1-like [IPR013538]", "Active zone protein ELKS [IPR019323]", "Activity-dependent neuroprotector homeobox protein [IPR038861]", "Acyl-CoA desaturase [IPR015876]", "Acyl-CoA oxidase [IPR012258]", "Acyl-coenzyme A thioesterase 13 [IPR039298]", "Acylneuraminate cytidylyltransferase [IPR003329]", "Acyltransferase ChoActase/COT/CPT [IPR000542]", "Adaptor protein complex AP-1, gamma subunit [IPR017107]", "Adaptor protein complex AP-2, alpha subunit [IPR017104]", "Adaptor protein complex AP-3, delta subunit [IPR017105]", "Adaptor protein complex, sigma subunit [IPR016635]", "Adenine phosphoribosyl transferase [IPR005764]", "Adenosine kinase [IPR001805]", "Adenosylhomocysteinase-like [IPR000043]", "Adenylate cyclase-associated CAP [IPR001837]", "Adenylate kinase 2 [IPR028587]", "Adenylate kinase isoenzyme 1 [IPR028582]", "Adenylate kinase isoenzyme 6 [IPR020618]", "Adenylate kinase subfamily [IPR006259]", "Adenylate kinase, isozyme 1/5 [IPR006267]", "Adenylate kinase/UMP-CMP kinase [IPR000850]", "Adenylosuccinate lyase [IPR004769]", "Adenylosuccinate synthetase [IPR001114]", "Adenylosuccinate synthetase isozyme 2, chordates [IPR027529]", "Adenylyl cyclase-associated protein CAP1 [IPR028415]", "Adenylyl-sulfate kinase [IPR002891]", "AdoMet-dependent rRNA methyltransferase Spb1-like [IPR028589]", "Aladin [IPR045139]", "Alanine-tRNA ligase, class IIc [IPR002318]", "Alanine-tRNA ligase, eukaryota/bacteria [IPR023033]", "Alcohol dehydrogenase class III [IPR014183]", "Aldehyde dehydrogenase NAD(P)-dependent [IPR012394]", "Aldehyde dehydrogenase family 7 member A1-like [IPR044638]", "Aldo-keto reductase [IPR020471]", "Aldo-keto reductase family 1 member A1 [IPR044481]", "Alkyldihydroxyacetonephosphate synthase [IPR025650]", "Alpha E-catenin/Alpha T-catenin [IPR030047]", "Alpha crystallin/Small heat shock protein, animal type [IPR001436]", "Alpha-2-macroglobulin receptor-associated protein [IPR038003]", "Alpha-D-phosphohexomutase superfamily [IPR005841]", "Alpha-L-fucosidase, metazoa-type [IPR016286]", "Alpha-N-acetylglucosaminidase [IPR007781]", "Alpha-N-methyltransferase NTM1 [IPR008576]", "Alpha-adducin [IPR027766]", "Alpha-catenin [IPR001033]", "Alpha-internexin [IPR027703]", "Alpha-ketoglutarate-dependent dioxygenase FTO [IPR032868]", "Amidase [IPR000120]", "Amidophosphoribosyltransferase [IPR005854]", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 [IPR042360]", "Aminoacyl-tRNA synthetase, class Ic [IPR002305]", "Aminopeptidase N-type [IPR034016]", "Aminopeptidase, leukotriene A4 hydrolase-like [IPR034015]", "Aminotransferase class IV [IPR001544]", "Aminotransferase class-III [IPR005814]", "AmpG-like permease/Acetyl-coenzyme A transporter 1 [IPR004752]", "Amyloid-beta precursor protein [IPR028866]", "Amyloidogenic glycoprotein [IPR008155]", "Anamorsin [IPR007785]", "Anaphase-promoting complex subunit 1 [IPR024990]", "Anaphase-promoting complex subunit 16 [IPR029641]", "Anaphase-promoting complex subunit 5 [IPR037679]", "Ancient conserved domain protein family [IPR045095]", "Angiomotin [IPR009114]", "Ankycorbin [IPR042420]", "Ankyrin repeat and LEM domain-containing protein 2 [IPR035007]", "Annexin A1 [IPR002388]", "Annexin A11 [IPR008157]", "Annexin A2 [IPR002389]", "Annexin A6 [IPR002393]", "Annexin [IPR001464]", "Antifreeze, type III [IPR006013]", "Antigen peptide transporter 1 [IPR013306]", "Antigen peptide transporter 2 [IPR005293]", "Apolipoprotein L [IPR008405]", "Apoptosis inhibitory 5 [IPR008383]", "Apoptosis regulator, Mcl-1 [IPR013281]", "Arginase [IPR014033]", "Arginine-tRNA ligase [IPR001278]", "Armadillo repeat-containing protein 6 [IPR040104]", "Arsenical pump ATPase, ArsA/GET3 [IPR016300]", "Arsenical pump ATPase, ArsA/GET3, eukaryotic [IPR027542]", "Arylesterase [IPR002640]", "Asparaginase-like 1, metazoa [IPR033844]", "Asparagine synthase, glutamine-hydrolyzing [IPR006426]", "Asparagine-tRNA ligase [IPR004522]", "Asparaginyl endopeptidase [IPR043577]", "Aspartate carbamoyltransferase [IPR002082]", "Aspartate-tRNA ligase, type 1 [IPR004524]", "Aspartate-tRNA synthetase, type 2 [IPR004523]", "Aspartate/ornithine carbamoyltransferase [IPR006130]", "Aspartate/other aminotransferase [IPR000796]", "Aspartyl/Asparaginyl-tRNA synthetase, class IIb [IPR002312]", "Aspartyl/asparaginyl beta-hydroxylase family [IPR039038]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit [IPR004413]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, subunit B /E [IPR017959]", "Ataxin2-like [IPR045117]", "Atypical dual specificity phosphatase, subfamily A [IPR020405]", "B-cell receptor-associated protein 29/31 [IPR008417]", "BBP/SF1 family [IPR031150]", "BCP1 family [IPR025602]", "BLOC-2 complex, Hps6 subunit [IPR017218]", "BRCA1-A complex subunit BRE [IPR010358]", "BRCA1-associated [IPR031099]", "BRI3-binding protein [IPR033367]", "BRISC and BRCA1-A complex member 1 [IPR026126]", "BRO1 domain-containing protein BROX [IPR038898]", "BTB-kelch protein [IPR017096]", "Bacterial/eukaryotic lysine-tRNA ligase, class II [IPR034762]", "Baculoviral IAP repeat-containing protein 6 [IPR022103]", "Band 4.1 protein, chordates [IPR021187]", "Band 4.1-like protein 2 [IPR030546]", "Barrier- to-autointegration factor, BAF [IPR004122]", "Basigin [IPR044157]", "Basigin-like [IPR043204]", "Bcl-2 family [IPR026298]", "Bcl-2-associated transcription factor 1 [IPR026668]", "Bcl2-like [IPR002475]", "Beta tubulin [IPR002453]", "Beta-1,4-glucuronyltransferase 1 [IPR043189]", "Beta-N-acetylglucosaminidase [IPR011496]", "Beta-catenin [IPR013284]", "Beta-catenin-like protein 1 [IPR039678]", "Beta-galactosidase 1-like [IPR026283]", "Beta-hexosaminidase [IPR025705]", "Beta-lactamase HcpB-like [IPR040239]", "Bifunctional purine biosynthesis protein PurH-like [IPR002695]", "Biliverdin reductase A [IPR017094]", "Biotin--acetyl-CoA-carboxylase ligase [IPR004408]", "BolA protein [IPR002634]", "BolA-like protein 2 [IPR045115]", "Brain acid soluble protein 1 [IPR008408]", "Branched-chain amino acid aminotransferase II [IPR005786]", "Branched-chain aminotransferase [IPR033939]", "Breast cancer type 1 susceptibility protein (BRCA1) [IPR011364]", "Bromodomain adjacent to zinc finger domain protein 2A [IPR028940]", "Bystin [IPR007955]", "C-5 cytosine methyltransferase [IPR001525]", "C-terminal binding protein [IPR043322]", "CAAX prenyl protease 1 [IPR027057]", "CCR4-NOT complex, subunit 3/ 5 [IPR012270]", "CCR4-NOT transcription complex subunit 1 [IPR040398]", "CCR4-NOT transcription complex subunit 10 [IPR039740]", "CCR4-NOT transcription complex subunit 7 [IPR039636]", "CCR4-NOT transcription complex subunit 7/8/Pop2 [IPR039637]", "CCR4-NOT transcription complex subunit 9 [IPR007216]", "CD2-associated protein [IPR028445]", "CD36 family [IPR002159]", "CD36/scavenger receptor class B member 1 [IPR005428]", "CDGSH iron-sulfur domain-containing protein 1/2 [IPR045131]", "CDK5 regulatory subunit-associated protein 3 [IPR008491]", "CDP-alcohol phosphatidyltransferase [IPR000462]", "CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote [IPR014387]", "CEBPZ/Mak21-like [IPR040155]", "CHORD domain containing protein [IPR039790]", "CLIP-associating protein 1 [IPR028399]", "CLU domain containing protein [IPR027523]", "COMM domain-containing protein 2 [IPR037354]", "COMPASS component Swd2/WDR82 [IPR037867]", "COP9 Signalosome complex subunit 7A [IPR037757]", "COP9 signalosome complex subunit 1 [IPR033008]", "COP9 signalosome complex subunit 2 [IPR037750]", "COP9 signalosome complex subunit 3 [IPR037753]", "COP9 signalosome complex subunit 4 [IPR037754]", "COP9 signalosome complex subunit 5 [IPR037740]", "COP9 signalosome subunit 6 [IPR033859]", "COP9 signalosome, subunit CSN8 [IPR033205]", "COPII coat assembly protein, Sec16 [IPR024880]", "CPSF6/7 family [IPR034772]", "CTP synthase [IPR004468]", "CXXC motif containing zinc binding protein, eukaryotic [IPR008584]", "CYFIP-related Rac1 interactor [IPR039789]", "Calcium homeostasis endoplasmic reticulum protein [IPR039037]", "Calcium load-activated calcium channel [IPR008559]", "Calcium uptake protein 1/2/3 [IPR039800]", "Calcium-binding mitochondrial carrier protein Aralar2 [IPR029658]", "Calcium-binding protein CAB45 [IPR027240]", "Caldesmon [IPR006017]", "Caldesmon/lymphocyte specific protein [IPR006018]", "Calpain-1 [IPR029643]", "Calpain-2 [IPR029539]", "Calpastatin [IPR026998]", "Calponin-2 [IPR029974]", "Calponin/LIMCH1 [IPR001997]", "Calreticulin [IPR009169]", "Calreticulin/calnexin [IPR001580]", "Calumenin [IPR027239]", "Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 1 [IPR030376]", "Caprin [IPR028816]", "Carbamoyl-phosphate synthase, large subunit [IPR006275]", "Carbamoyl-phosphate synthase, small subunit [IPR006274]", "Carbohydrate sulfotransferase 8-10 [IPR018011]", "Cartilage-associated protein [IPR033212]", "Casein kinase II, regulatory subunit [IPR000704]", "Cat eye syndrome critical region protein 2 [IPR029614]", "Cat eye syndrome critical region protein 5 [IPR029621]", "Catechol O-methyltransferase, eukaryotic [IPR017128]", "Catenin delta-1 [IPR028439]", "Ccdc97-like [IPR018613]", "Cdc37 [IPR004918]", "Cdc42 [IPR037874]", "Cdc73/Parafibromin [IPR007852]", "Cell cycle and apoptosis regulator protein 2 [IPR028811]", "Cell cycle and apoptosis regulator protein [IPR025224]", "Cell division cycle protein 123 [IPR009772]", "Cell division protein borealin [IPR018867]", "Cell growth-regulating nucleolar protein [IPR039999]", "Cell-cycle alteration and expression-elevated protein in tumour [IPR032337]", "Centromere protein I [IPR012485]", "Centrosomal protein of 170kDa [IPR026644]", "Ceroid-lipofuscinosis neuronal protein 5 [IPR026138]", "Cgr1-like [IPR005579]", "Chaperone DnaJ [IPR012724]", "Chaperone DnaK [IPR012725]", "Chaperone tailless complex polypeptide 1 (TCP-1) [IPR017998]", "Chaperonin Cpn60/GroEL [IPR001844]", "Chaperonin Cpn60/GroEL/TCP-1 family [IPR002423]", "Chloride channel ClC-3 [IPR002245]", "Chloride channel, voltage gated [IPR001807]", "Chloride intracellular channel protein 1 [IPR030259]", "Chromatid cohesion factor MAU2 [IPR019440]", "Chromatin assembly factor 1 subunit Cac2/CHAF1B/FAS2 [IPR045145]", "Chromatin-remodeling complex component Sfh1/SNF5 [IPR017393]", "Chromobox protein homologue 3 [IPR038033]", "Chromosome alignment-maintaining phosphoprotein 1 [IPR039330]", "Cilia- and flagella-associated protein 20/CFAP20DC [IPR040441]", "Cip1-interacting zinc finger protein [IPR026811]", "Citrate synthase [IPR002020]", "Citrate synthase, eukaryotic-type [IPR010109]", "Class I-like SAM-dependent O-methyltransferase [IPR002935]", "Clathrin adaptor, mu subunit [IPR001392]", "Clathrin coat assembly protein AP180-like [IPR045192]", "Clathrin interactor 1 [IPR030544]", "Clathrin, heavy chain [IPR016341]", "Cleavage and polyadenylation specificity factor subunit 2 [IPR027075]", "Cleavage and polyadenylation specificity factor subunit 6 [IPR034769]", "Cleavage and polyadenylation specificity factor subunit 7 [IPR034770]", "Cleavage stimulation factor subunit 1-like [IPR044633]", "Cleavage stimulation factor subunit 2 [IPR033105]", "Cleavage/polyadenylation specificity factor subunit 5 [IPR016706]", "Cleft lip and palate transmembrane 1 [IPR008429]", "Cleft lip and palate transmembrane protein 1-like protein [IPR030434]", "Clp protease proteolytic subunit /Translocation-enhancing protein TepA [IPR023562]", "Clp protease, ATP-binding subunit ClpX [IPR004487]", "ClpA/B family [IPR001270]", "Co-chaperone protein p23-like [IPR045250]", "Coactosin-like protein [IPR030502]", "Coatomer alpha subunit [IPR016391]", "Coatomer beta subunit (COPB1) [IPR016460]", "Coatomer beta' subunit (COPB2) [IPR016453]", "Coatomer delta subunit [IPR027059]", "Coatomer gamma subunit [IPR017106]", "Coatomer subunit zeta [IPR039652]", "Cobalamin-dependent methionine synthase [IPR011822]", "Cofilin 1 [IPR027234]", "Cohesin subunit Scc3/SA [IPR039662]", "Coiled-coil domain-containing protein 124/Oxs1 [IPR010422]", "Coiled-coil domain-containing protein 86 [IPR026570]", "Coilin [IPR024822]", "Complex I intermediate-associated protein 30, mitochondrial [IPR039131]", "Condensin complex subunit 2/barren [IPR022816]", "Condensin complex subunit 3 [IPR027165]", "Condensin subunit 1 [IPR007673]", "Condensin subunit 1/Condensin-2 complex subunit D3 [IPR026971]", "Conserved oligomeric Golgi complex subunit 7 [IPR019335]", "Constitutive coactivator of PPAR-gamma [IPR026784]", "Copine [IPR045052]", "Copper chaperone SCO1/SenC [IPR003782]", "Coproporphyrinogen III oxidase, aerobic [IPR001260]", "Core histone macro-H2A [IPR021171]", "Coronin 1B [IPR027340]", "Coronin 1C [IPR027333]", "Coronin [IPR015505]", "Cortactin [IPR015503]", "Cullin [IPR045093]", "Cullin-4B [IPR033044]", "Cullin-associated NEDD8-dissociated protein 1/2 [IPR039852]", "Cwf19-like protein [IPR040194]", "Cyclic nucleotide phosphodiesterase [IPR008431]", "Cyclin-dependent kinase 6 [IPR028788]", "Cyclophilin-RNA interacting protein [IPR035542]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase [IPR024936]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like [IPR044666]", "Cysteine protease ATG4B, metazoa [IPR032916]", "Cysteine-tRNA ligase [IPR015803]", "Cysteinyl-tRNA synthetase/mycothiol ligase [IPR024909]", "Cystinyl aminopeptidase [IPR034017]", "Cytochrome P450 [IPR001128]", "Cytochrome P450, E-class, group IV [IPR002403]", "Cytochrome b-c1 complex subunit 8 [IPR004205]", "Cytochrome b-c1 complex subunit 9 [IPR008027]", "Cytochrome c oxidase assembly factor 3, mitochondrial [IPR041752]", "Cytochrome c oxidase subunit 6C [IPR004204]", "Cytochrome c oxidase subunit IV [IPR013288]", "Cytochrome c oxidase subunit IV family [IPR004203]", "Cytochrome c oxidase subunit VII [IPR039297]", "Cytochrome c oxidase subunit VIIa, metazoa [IPR003177]", "Cytochrome c oxidase subunit VIIc [IPR004202]", "Cytochrome c oxidase, subunit Va/VI [IPR003204]", "Cytochrome c oxidase, subunit Vb [IPR002124]", "Cytochrome c/quinol oxidase subunit II [IPR045187]", "Cytochrome c1 [IPR002326]", "Cytoplasmic FMR1-interacting [IPR008081]", "Cytoplasmic dynein 1 intermediate chain 1/2 [IPR025956]", "Cytoskeleton-associated protein 2 family [IPR026165]", "Cytoskeleton-associated protein 4 [IPR028428]", "Cytosolic Fe-S cluster assembly factor NUBP2/Cfd1, eukaryotes [IPR028600]", "Cytosolic acyl coenzyme A thioester hydrolase [IPR040170]", "Cytosolic nonspecific dipeptidase/DUG1 [IPR017153]", "D-3-phosphoglycerate dehydrogenase [IPR006236]", "DAD/Ost2 [IPR003038]", "DDRGK domain containing protein [IPR019153]", "DDX54/DBP10 family [IPR033517]", "DENR family, eukaryotes [IPR005873]", "DNA (cytosine-5)-methyltransferase 1-like [IPR017198]", "DNA damage-binding protein 1 [IPR031297]", "DNA double-strand break repair protein Mre11 [IPR003701]", "DNA fragmentation factor 45 [IPR017299]", "DNA helicase, ATP-dependent, RecQ type [IPR004589]", "DNA ligase, ATP-dependent [IPR000977]", "DNA mismatch repair Msh2-type [IPR011184]", "DNA mismatch repair MutS family [IPR045076]", "DNA mismatch repair protein Msh2 [IPR032642]", "DNA mismatch repair protein MutS/MSH [IPR017261]", "DNA polymerase V/Myb-binding protein 1A [IPR007015]", "DNA polymerase epsilon catalytic subunit [IPR029703]", "DNA primase large subunit, eukaryotic/archaeal [IPR007238]", "DNA primase, large subunit, eukaryotic [IPR016558]", "DNA primase, small subunit [IPR002755]", "DNA primase, small subunit, eukaryotic/archaeal [IPR014052]", "DNA repair protein Rad50, eukaryotes [IPR004584]", "DNA repair/transcription protein MET18/MMS19 [IPR039920]", "DNA replication licensing factor Mcm2 [IPR008045]", "DNA replication licensing factor Mcm3 [IPR008046]", "DNA replication licensing factor Mcm5 [IPR008048]", "DNA replication licensing factor Mcm6 [IPR008049]", "DNA replication licensing factor Mcm7 [IPR008050]", "DNA topoisomerase I [IPR001631]", "DNA topoisomerase II, eukaryotic-type [IPR001154]", "DNA topoisomerase II-beta [IPR028467]", "DNA topoisomerase, type IIA [IPR001241]", "DNA-directed DNA polymerase, family B [IPR006172]", "DNA-directed RNA pol I, largest subunit [IPR015699]", "DNA-directed RNA polymerase I, subunit RPA34.5 [IPR013240]", "DNA-directed RNA polymerase III subunit RPC3 [IPR039748]", "DNA-directed RNA polymerase subunit Rpo5/Rpb5 [IPR014381]", "DNA-directed RNA polymerase, phage-type [IPR002092]", "DNA-directed RNA polymerase, subunit 2 [IPR015712]", "DNA-directed RNA polymerase, subunit beta-prime [IPR045867]", "DNA-directed RNA polymerases I and III subunit AC40 [IPR033901]", "DNA2/NAM7-like helicase [IPR045055]", "DPM1-like [IPR039528]", "Death-inducer obliterator 1 [IPR033082]", "Dedicator of cytokinesis [IPR026791]", "Delta l-pyrroline-5-carboxylate synthetase [IPR005766]", "Delta(24)-sterol reductase [IPR040165]", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase Ech1-like [IPR045002]", "Deoxyhypusine hydroxylase [IPR027517]", "Deoxyhypusine synthase [IPR002773]", "Deoxynucleoside kinase [IPR002624]", "Deoxyuridine triphosphate nucleotidohydrolase [IPR008181]", "Dephospho-CoA kinase [IPR001977]", "Derlin [IPR007599]", "Dermcidin [IPR028130]", "Dermcidin/Lacritin [IPR043557]", "Desmoglein [IPR009123]", "Desmoplakin [IPR028462]", "Desmosomal cadherin [IPR009122]", "Destrin [IPR029924]", "Deubiquitinating enzyme MINDY-3/4 [IPR039785]", "Developmentally regulated GTP-binding protein [IPR045001]", "Dihydrofolate reductase [IPR012259]", "Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component [IPR045257]", "Dihydrolipoamide dehydrogenase [IPR006258]", "Dihydrolipoamide succinyltransferase [IPR006255]", "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex [IPR006257]", "Dihydropyrimidinase-related protein 2 [IPR030615]", "Dihydroxyacetone phosphate acyltransferase [IPR028353]", "Dipeptidyl-peptidase 3 [IPR005317]", "Diphthamide synthesis DHP2 [IPR010014]", "Diphthamide synthesis DPH1/DPH2 [IPR016435]", "Divalent ion tolerance protein, CutA [IPR004323]", "DnaJ homolog subfamily A member 1/2-like [IPR044713]", "DnaJ homolog subfamily C member 8 [IPR042858]", "DnaJ homologue subfamily C member 10 [IPR021170]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48kDa subunit [IPR005013]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1 [IPR008814]", "Drebrin [IPR028438]", "Drebrin-like protein [IPR029923]", "Dynactin subunit 3 [IPR009991]", "Dynactin subunit 4 [IPR008603]", "Dynamin [IPR022812]", "Dynamin-1-like protein [IPR030556]", "Dynamin-2 [IPR027188]", "Dynamin-like 120kDa protein, mitochondrial [IPR033047]", "Dynamitin [IPR028133]", "Dynein 1 light intermediate chain [IPR008467]", "Dynein family light intermediate chain [IPR022780]", "Dynein light chain, type 1/2 [IPR001372]", "Dynein regulator LIS1 [IPR017252]", "Dystrophin/utrophin [IPR035436]", "E3 SUMO-protein ligase Nse2 (Mms21) [IPR026846]", "E3 UFM1-protein ligase 1 [IPR018611]", "E3 ubiquitin ligase Bre1 [IPR013956]", "E3 ubiquitin ligase RBR family [IPR031127]", "E3 ubiquitin ligase UBR4-like [IPR045189]", "E3 ubiquitin-protein ligase ARIH2 [IPR031126]", "E3 ubiquitin-protein ligase CHIP/LubX [IPR045200]", "E3 ubiquitin-protein ligase HECTD1/TRIP12-like [IPR045322]", "E3 ubiquitin-protein ligase RBBP6 family [IPR033489]", "E3 ubiquitin-protein ligase UBR7 [IPR040204]", "E3 ubiquitin-protein ligase listerin [IPR039795]", "E3 ubiquitin-protein ligase, SMURF1 type [IPR024928]", "EB1, Metazoa [IPR027739]", "EB2, vertebrate [IPR027735]", "ECSIT [IPR010418]", "EH domain-containing protein 1/3 [IPR029951]", "ELL/occludin family [IPR031176]", "ELMO domain-containing protein 2 [IPR030724]", "ER lumen protein retaining receptor [IPR000133]", "ER membrane protein complex subunit 1 [IPR026895]", "ER membrane protein complex subunit 2-like [IPR039856]", "ER membrane protein complex subunit 7 [IPR039163]", "ERAP2 aminopeptidase [IPR033528]", "ERG2/sigma1 receptor-like [IPR006716]", "ERp19 [IPR037462]", "Electron transfer flavoprotein alpha subunit/FixB [IPR001308]", "Electron transfer flavoprotein, beta subunit [IPR012255]", "Electron transfer flavoprotein-ubiquinone oxidoreductase [IPR040156]", "Elongation factor G1-like [IPR045044]", "Elongator complex protein 1 [IPR006849]", "Elongator complex protein 2 [IPR037289]", "Elongin B [IPR039049]", "Emerin [IPR035004]", "Endophilin-A [IPR028501]", "Endophilin-B1 [IPR028503]", "Endoplasmic reticulum aninopeptidase 1 [IPR033520]", "Endoplasmic reticulum oxidoreductin 1 [IPR007266]", "Endoplasmic reticulum protein SC65 [IPR033213]", "Endoplasmic reticulum resident protein 29 [IPR016855]", "Endoplasmic reticulum vesicle transporter [IPR045888]", "Endosulphine [IPR006760]", "Endothelin-converting enzyme 1 [IPR029734]", "Enhancer of mRNA-decapping protein 4-like [IPR045152]", "Enhancer of rudimentary [IPR000781]", "Enolase [IPR000941]", "Enoyl-CoA hydratase/isomerase [IPR001753]", "Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type [IPR032259]", "Ephrin receptor type-A /type-B [IPR016257]", "Epimerase family protein SDR39U1 [IPR010099]", "Epoxide hydrolase [IPR016292]", "Epoxide hydrolase-like [IPR000639]", "Ergosterol biosynthesis ERG4/ERG24 [IPR001171]", "Erlin1/2 [IPR033294]", "Esterase-like [IPR000801]", "Eukaryotic porin/Tom40 [IPR027246]", "Eukaryotic rRNA processing [IPR008610]", "Eukaryotic translation elongation factor 1 epsilon-1 [IPR042450]", "Eukaryotic translation initiation factor 3 subunit A [IPR027512]", "Eukaryotic translation initiation factor 3 subunit B [IPR011400]", "Eukaryotic translation initiation factor 3 subunit D [IPR007783]", "Eukaryotic translation initiation factor 3 subunit E [IPR016650]", "Eukaryotic translation initiation factor 3 subunit F [IPR027531]", "Eukaryotic translation initiation factor 3 subunit G [IPR017334]", "Eukaryotic translation initiation factor 3 subunit H [IPR027524]", "Eukaryotic translation initiation factor 3 subunit I [IPR027525]", "Eukaryotic translation initiation factor 3 subunit J [IPR013906]", "Eukaryotic translation initiation factor 3 subunit K [IPR009374]", "Eukaryotic translation initiation factor 3 subunit M [IPR027528]", "Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7 [IPR045237]", "Eukaryotic translation initiation factor 4 gamma 1 [IPR037584]", "Eukaryotic translation initiation factor 4 gamma 3 [IPR037585]", "Eukaryotic translation initiation factor 4B [IPR033107]", "Exocyst complex component EXOC2/Sec5 [IPR029175]", "Exocyst complex component EXOC3/Sec6 [IPR010326]", "Exocyst complex component EXOC5/Sec10 [IPR033960]", "Exocyst complex component Exo70 [IPR004140]", "Exocyst complex component Sec10-like [IPR009976]", "Exonuclease 1 [IPR032641]", "Exosome complex RNA-binding protein 1/RRP40/RRP4 [IPR026699]", "Exosome complex component Csl4 [IPR039771]", "Exosome complex exonuclease Rrp6-like [IPR045092]", "Exportin 4/7-like [IPR044189]", "Exportin-1/5 [IPR045065]", "Exportin-5 [IPR040018]", "Exportin-7 [IPR040021]", "Ezrin/radixin/moesin [IPR011174]", "Ezrin/radixin/moesin-like [IPR000798]", "F-actin-capping protein subunit alpha [IPR002189]", "F-actin-capping protein subunit beta [IPR001698]", "FACT complex subunit Spt16 [IPR040258]", "FAD synthetase with the MoaB/Mog domain [IPR012183]", "FAD-dependent glycerol-3-phosphate dehydrogenase [IPR000447]", "FAD-dependent oxidoreductase SdhA/FrdA/AprA [IPR030664]", "FAM98 [IPR018797]", "FUN14 [IPR007014]", "Family of unknown function DUF5525 [IPR037656]", "Fanconi anemia group I protein [IPR026171]", "Fascin [IPR010431]", "Fascin, metazoans [IPR024703]", "Fascin-1 [IPR030146]", "Fatty acid desaturase [IPR012171]", "Fatty acid oxidation complex, alpha subunit, mitochondrial [IPR012803]", "Fatty acid transport protein 4 [IPR030304]", "Fatty acyl-CoA reductase [IPR026055]", "Fcf2/DNTTIP2 [IPR039883]", "Ferrochelatase [IPR001015]", "Fibrillarin [IPR000692]", "Filamin family [IPR044801]", "Filamin-B [IPR029874]", "Fimbrin/Plastin [IPR039959]", "Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 [IPR033756]", "Flap endonuclease 1 [IPR023426]", "Flotillin family [IPR027705]", "Forkhead box protein C1 [IPR033067]", "Formate-tetrahydrofolate ligase, FTHFS [IPR000559]", "Formin, protein diaphanous homologue 1 [IPR027653]", "Formin, protein diaphanous homologue 3 [IPR027654]", "Four and a half LIM domains protein 1 [IPR042997]", "Fragile X mental retardation syndrome-related protein [IPR040148]", "Fructosamine/Ketosamine-3-kinase [IPR016477]", "Fructose-bisphosphate aldolase, class-I [IPR000741]", "Fumarate hydratase, class II [IPR005677]", "Fumarate lyase family [IPR000362]", "Fumarylacetoacetase [IPR005959]", "G-protein alpha subunit, group 12/13 [IPR000469]", "G-protein alpha subunit, group I [IPR001408]", "G-rich sequence factor 1 [IPR033106]", "GDP dissociation inhibitor [IPR018203]", "GDP-L-fucose synthase/GDP-L-colitose synthase [IPR028614]", "GINS complex subunit Sld5 [IPR008591]", "GINS complex, subunit Psf1 [IPR005339]", "GPCR-associated sorting protein [IPR043374]", "GPI transamidase component Gaa1 [IPR007246]", "GPI transamidase component PIG-T [IPR007245]", "GRASP55/65 [IPR007583]", "GRIP1-associated protein 1 [IPR026204]", "GTP-binding protein 1 [IPR039263]", "GTP-binding protein Era [IPR005662]", "GTP-binding protein Obg/CgtA [IPR014100]", "Galactokinase [IPR000705]", "Gamma-adducin [IPR027772]", "Gamma-glutamylcyclotransferase [IPR017939]", "Gamma-tubulin complex component protein [IPR007259]", "Ganglioside GM2 activator [IPR028996]", "Gem-associated protein 4 [IPR033265]", "General transcription factor 3C polypeptide 4 [IPR044230]", "Geranylgeranyl transferase type-2 subunit alpha [IPR032955]", "Glomulin/ALF4 [IPR019516]", "Glucosamine-6-phosphate isomerase [IPR004547]", "Glucosamine-fructose-6-phosphate aminotransferase, isomerising [IPR005855]", "Glucose-6-phosphate dehydrogenase [IPR001282]", "Glucosidase II beta subunit-like [IPR039794]", "Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase [IPR005715]", "Glutamate carboxypeptidase 2-like [IPR039373]", "Glutamate/acetylglutamate kinase [IPR001057]", "Glutamate/phenylalanine/leucine/valine dehydrogenase [IPR006095]", "Glutaminase [IPR015868]", "Glutamine-tRNA synthetase [IPR004514]", "Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic [IPR004526]", "Glutamyl-tRNA(Gln) amidotransferase A subunit [IPR004412]", "Glutamyl/glutaminyl-tRNA synthetase [IPR000924]", "Glutathione S-transferase Omega/Tau-like [IPR045073]", "Glutathione S-transferase kappa [IPR044088]", "Glutathione S-transferase, Mu class [IPR003081]", "Glutathione S-transferase, omega-class [IPR005442]", "Glutathione S-transferases, class Zeta [IPR005955]", "Glutathione Transferase family [IPR040079]", "Glutathione reductase, eukaryote/bacterial [IPR006322]", "Glutathione synthase [IPR005615]", "Glyceraldehyde-3-phosphate dehydrogenase, type I [IPR006424]", "Glyceraldehyde/Erythrose phosphate dehydrogenase family [IPR020831]", "Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase [IPR022284]", "Glycine cleavage system P protein [IPR020581]", "Glycine dehydrogenase (decarboxylating) [IPR003437]", "Glycogen debranching enzyme [IPR010401]", "Glycogen debranching enzyme, metazoa [IPR006421]", "Glycogen synthase [IPR008631]", "Glycogen synthase kinase-3 beta [IPR033573]", "Glycogen/starch/alpha-glucan phosphorylase [IPR011833]", "Glycoside hydrolase family 30 [IPR001139]", "Glycoside hydrolase family 31 [IPR000322]", "Glycoside hydrolase family 63 [IPR004888]", "Glycoside hydrolase, family 2 [IPR006101]", "Glycoside hydrolase, family 27 [IPR002241]", "Glycoside hydrolase, family 29 [IPR000933]", "Glycoside hydrolase, family 35 [IPR001944]", "Glycosyl transferase, family 25 [IPR002654]", "Glycosyl transferase, family 35 [IPR000811]", "Glycyl-tRNA synthetase [IPR002315]", "Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2 [IPR027031]", "Glyoxalase I [IPR004361]", "Glyoxalase domain-containing protein 4 [IPR043193]", "Golgi apparatus protein 1 [IPR039728]", "Golgi integral membrane protein 4 [IPR042336]", "Golgi to ER traffic protein 4 [IPR007317]", "Golgin subfamily A member 3 [IPR033288]", "Golgin subfamily B member 1 [IPR026202]", "Graves disease carrier protein [IPR002167]", "GroES chaperonin family [IPR020818]", "Growth arrest/ DNA-damage-inducible protein-interacting protein 1 [IPR018472]", "GrpE nucleotide exchange factor [IPR000740]", "Guanine nucleotide binding protein (G-protein), alpha subunit [IPR001019]", "Guanine nucleotide-exchange factor Sec12-like [IPR045260]", "Guided entry of tail-anchored proteins factor CAMLG [IPR016719]", "H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 [IPR007504]", "H/ACA ribonucleoprotein complex, subunit Nhp2, eukaryote [IPR002415]", "HAD hydrolase, subfamily IA [IPR006439]", "HAD-superfamily hydrolase, subfamily IA, REG-2-like [IPR011949]", "HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase [IPR008380]", "HAD-superfamily hydrolase, subfamily IIA [IPR006357]", "HAD-superfamily hydrolase, subfamily IIA, CECR5 [IPR006353]", "HAUS augmin-like complex subunit 5 [IPR029131]", "HAUS complex subunit 5, metazoa [IPR026215]", "HCCA isomerase/glutathione S-transferase kappa [IPR014440]", "HMG-CoA lyase [IPR043594]", "HS1-associating protein X-1 [IPR017248]", "Haem oxygenase [IPR002051]", "Haem oxygenase-like [IPR016053]", "Haloacid dehalogenase-like hydrolase [IPR041492]", "Ham1-like protein [IPR002637]", "Heat shock 70kDa protein 13 [IPR042048]", "Heat shock protein 70 family [IPR013126]", "Heat shock protein Hsp90 family [IPR001404]", "Heat shock protein Sti1-like [IPR045248]", "Helicase MOV-10 [IPR026122]", "Helicase XPB/Ssl2 [IPR001161]", "Helicase superfamily 1/2, DinG/Rad3-like [IPR045028]", "Heterochromatin protein 1-binding protein 3 [IPR033061]", "Heterogeneous nuclear ribonucleoprotein C [IPR017347]", "Heterogeneous nuclear ribonucleoprotein K [IPR033090]", "Heterogeneous nuclear ribonucleoprotein M [IPR024667]", "Heterogeneous nuclear ribonucleoprotein U [IPR026745]", "Heterogeneous nuclear ribonucleoprotein U-like protein 1 [IPR027025]", "Hexokinase [IPR001312]", "High mobility group protein HMG-I/HMG-Y, chordates [IPR031079]", "High mobility group protein HMGA [IPR000116]", "High mobility group protein HMGB1 [IPR031076]", "High mobility group protein HMGB3 [IPR031077]", "Histidine acid phosphatase, eukaryotic [IPR016274]", "Histidine phosphatase superfamily, clade-1 [IPR013078]", "Histidine phosphatase superfamily, clade-2 [IPR000560]", "Histidine triad (HIT) protein [IPR001310]", "Histone H2A [IPR002119]", "Histone H4 [IPR001951]", "Histone PARylation factor 1 [IPR019361]", "Histone acetyltransferase type B, catalytic subunit [IPR017380]", "Histone deacetylase [IPR003084]", "Histone deacetylase complex, SAP18 subunit [IPR017250]", "Histone deacetylase family [IPR000286]", "Histone demethylase JHDM2-like [IPR045109]", "Histone lysine-specific demethylase [IPR017366]", "Histone-lysine N-methyltransferase 2A [IPR037927]", "Histone-lysine N-methyltransferase Smyd3 [IPR025805]", "HnRNP R/Q splicing factor [IPR006535]", "HnRNP-L/PTB [IPR006536]", "Holocytochrome c/c1 synthase [IPR000511]", "Homeobox protein Hox-A10/abdominal-B-like [IPR046333]", "Host cell factor 1 [IPR037854]", "Host cell factor [IPR043536]", "Huntingtin [IPR000091]", "Huntingtin family [IPR028426]", "Hydantoinase/dihydropyrimidinase [IPR011778]", "Hydroxymethylglutaryl-CoA synthase, eukaryotic [IPR010122]", "Hypoxanthine phosphoribosyl transferase [IPR005904]", "Hypoxia-inducible factor 1-alpha inhibitor [IPR027445]", "I-BAR domain containing protein IRSp53 [IPR030128]", "I-BAR domain containing protein IRSp53/IRTKS/Pinkbar [IPR027681]", "ICln [IPR003521]", "Immunity-related GTPase family Q protein [IPR040070]", "Importin beta family [IPR040122]", "Importin subunit alpha [IPR024931]", "Inhibitor of nuclear factor kappa-B kinase-interacting protein [IPR024152]", "Initiation factor 2B alpha/beta/delta [IPR011559]", "Initiation factor 2B-related [IPR000649]", "Initiation factor 4G [IPR045208]", "Inner centromere protein [IPR039130]", "Inner nuclear membrane protein Man1 [IPR034997]", "Inorganic pyrophosphatase [IPR008162]", "Inosine triphosphate pyrophosphatase [IPR027502]", "Inosine-5'-monophosphate dehydrogenase [IPR005990]", "Insulin receptor substrate [IPR039011]", "Integral membrane protein EMC3/TMCO1-like [IPR002809]", "Integrator complex subunit 14 [IPR039841]", "Integrator complex subunit 3 [IPR045334]", "Integrin beta subunit [IPR015812]", "Integrin beta-1 subunit [IPR027071]", "Interferon-induced protein with tetratricopeptide repeat 5 [IPR024125]", "Interleukin enhancer-binding factor 3 [IPR033099]", "Intracellular chloride channel [IPR002946]", "Intraflagellar transport protein 27 homologue, eukaryotes [IPR034112]", "Inverted formin-2 [IPR027649]", "Iron regulatory protein 1 [IPR029784]", "Isocitrate dehydrogenase NAD-dependent [IPR004434]", "Isocitrate dehydrogenase NADP-dependent [IPR004790]", "Isoleucine-tRNA ligase [IPR002301]", "Isoleucine-tRNA ligase, type 1 [IPR023585]", "Isoleucine-tRNA ligase, type 2 [IPR023586]", "Isopentenyl-diphosphate delta-isomerase, type 1 [IPR011876]", "Isoprenylcysteine carboxyl methyltransferase [IPR007269]", "Isovaleryl-CoA dehydrogenase [IPR034183]", "J-protein Zuotin/DnaJC2 [IPR044634]", "JNK-interacting protein 3/4 [IPR039911]", "Junction plakoglobin [IPR030461]", "Junctional adhesion molecule A [IPR042456]", "KH domain-containing BBP-like [IPR045071]", "KIF-1 binding protein [IPR022083]", "KRR1 interacting protein 1 [IPR018034]", "Kelch-like ECH-associated protein 1 [IPR030563]", "Keratin, type I [IPR002957]", "Keratinocyte-associated transmembrane protein 2 [IPR037645]", "Kindlin/fermitin [IPR037843]", "Kinectin [IPR024854]", "Kinesin light chain [IPR002151]", "Kinesin-like protein KIF22 (Kid) [IPR026986]", "Kinesin-like protein [IPR027640]", "Ku70 [IPR006165]", "Ku80 [IPR024193]", "Kynurenine--oxoglutarate transaminase 3 [IPR034612]", "L-lactate dehydrogenase [IPR011304]", "L-lactate/malate dehydrogenase [IPR001557]", "LAMTOR1/MEH1 [IPR028209]", "LETM1/MDM38-like [IPR044202]", "LIM domain and actin-binding protein 1 [IPR028740]", "LIM domain and actin-binding protein LIMA-like [IPR045268]", "La domain containing protein [IPR045180]", "LanC-like protein, eukaryotic [IPR020464]", "Lanthionine synthetase C-like [IPR007822]", "Las1 [IPR007174]", "Lethal(2) giant larvae protein [IPR000664]", "Leucine-rich PPR motif-containing protein [IPR033490]", "Leucine-rich repeat protein SHOC2 [IPR027036]", "Leucine-tRNA ligase [IPR002302]", "Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic [IPR004493]", "Leukotriene A4 hydrolase/leucine aminopeptidase [IPR012777]", "Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase [IPR014190]", "Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3 [IPR027141]", "Linker histone H1/H5 [IPR005819]", "Lipase, eukaryotic [IPR025483]", "Lipid droplet-associated hydrolase [IPR019363]", "Lon protease [IPR027065]", "Lon protease homologue, chloroplastic/mitochondrial [IPR027503]", "Lon protease, bacterial/eukaryotic-type [IPR004815]", "Long-chain fatty acid CoA synthetase, eukaryotic [IPR045311]", "Low temperature viability protein Ltv1 [IPR007307]", "Luc7-related [IPR004882]", "Lupus La protein [IPR002344]", "Lysine-tRNA ligase, class II [IPR002313]", "Lysophosphatidylserine lipase ABHD12 [IPR026605]", "Lysosome membrane protein II [IPR005429]", "Lysosome-associated membrane glycoprotein [IPR002000]", "MCT-1/Tma20 [IPR016437]", "MDN2-binding protein [IPR039061]", "MICOS complex subunit MIC19/MIC25 [IPR007964]", "MICOS complex subunit MIC26/MIC27 [IPR019166]", "MICOS complex subunit MIC26/MIC27, animal [IPR033182]", "MICOS complex subunit Mic13 [IPR026769]", "MOB kinase activator family [IPR005301]", "MRG [IPR008676]", "MRPS27/PTCD2 [IPR034913]", "Macrophage migration inhibitory factor [IPR001398]", "Magnesium transporter protein 1 [IPR006844]", "Major centromere autoantigen B [IPR033062]", "Major facilitator superfamily [IPR011701]", "Mak16 protein [IPR006958]", "Malate dehydrogenase, NAD-dependent, cytosolic [IPR011274]", "Malate dehydrogenase, type 1 [IPR010097]", "Malate dehydrogenase, type 2 [IPR010945]", "Malectin [IPR039155]", "Malic oxidoreductase [IPR001891]", "Manganese/iron superoxide dismutase [IPR001189]", "Mannose-6-phosphate isomerase [IPR016305]", "Mannose-6-phosphate isomerase, type I [IPR001250]", "Mediator complex, subunit Med16 [IPR021665]", "Medium-chain dehydrogenase/reductase [IPR045010]", "Medium-chain specific acyl-CoA dehydrogenase [IPR034180]", "Melanoma-associated antigen D2 [IPR028810]", "Melanoma-associated antigen [IPR037445]", "Membrane bound O-acyl transferase, MBOAT [IPR004299]", "Membrane magnesium transporter [IPR018937]", "Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein [IPR001129]", "Mesoderm induction early response protein/metastasis-associated protein [IPR040138]", "Metal-dependent protein hydrolase [IPR003226]", "Metastasis-associated protein MTA2 [IPR037964]", "Methionine-tRNA ligase, type 1 [IPR023458]", "Methionyl-tRNA synthetase [IPR014758]", "Methyl-CpG binding protein MeCP2 [IPR017353]", "Methyl-CpG binding protein MeCP2/MBD4 [IPR045138]", "Methyl-CpG-binding domain protein 3 [IPR037965]", "Methylcrotonoyl-CoA carboxylase beta chain MCCB/AccD1-like [IPR045190]", "Methylmalonate-semialdehyde dehydrogenase [IPR010061]", "Methylthioadenosine phosphorylase (MTAP) [IPR010044]", "Methylthioribose-1-phosphate isomerase [IPR005251]", "Methylthiotransferase [IPR005839]", "Methyltransferase, trithorax [IPR016569]", "Mevalonate/galactokinase [IPR006206]", "MiaB-like tRNA modifying enzyme, archaeal-type [IPR006466]", "Microprocessor complex subunit DGCR8 [IPR040375]", "Microtubule associated protein 1 [IPR026074]", "Microtubule-associated protein 1B [IPR027321]", "Microtubule-associated protein 1S [IPR027322]", "Microtubule-associated protein 4 [IPR027323]", "Microtubule-associated protein Jupiter [IPR033335]", "Microtubule-associated protein RP/EB [IPR027328]", "Microtubule-associated protein, MAP65/Ase1/PRC1 [IPR007145]", "Midasin [IPR012099]", "Midline-1 [IPR027727]", "Mini-chromosome maintenance complex protein 4 [IPR008047]", "Mini-chromosome maintenance complex-binding protein [IPR019140]", "Mini-chromosome maintenance protein [IPR031327]", "Mitochondrial 18kDa protein [IPR019560]", "Mitochondrial 28S ribosomal protein S31 [IPR026299]", "Mitochondrial 28S ribosomal protein S34 [IPR032053]", "Mitochondrial ATP synthase subunit g, animal [IPR016702]", "Mitochondrial ATPase inhibitor [IPR007648]", "Mitochondrial F1-F0 ATP synthase subunit F, predicted [IPR019344]", "Mitochondrial Rho GTPase 1 [IPR029506]", "Mitochondrial Rho GTPase [IPR021181]", "Mitochondrial carrier UCP-like [IPR002030]", "Mitochondrial carrier protein [IPR002067]", "Mitochondrial glycoprotein [IPR003428]", "Mitochondrial import inner membrane translocase subunit Tim44 [IPR017303]", "Mitochondrial import inner membrane translocase subunit Tim50 [IPR027111]", "Mitochondrial import inner membrane translocase subunit Tim8/13 [IPR039238]", "Mitochondrial import receptor subunit TOM5, metazoa [IPR029179]", "Mitochondrial import receptor subunit Tom22 [IPR005683]", "Mitochondrial inner membrane protein Mitofilin [IPR019133]", "Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678]", "Mitochondrial inner membrane translocase complex, subunit Tim23 [IPR005681]", "Mitochondrial outer membrane translocase complex, subunit Tom5 [IPR019603]", "Mitochondrial outer membrane transport complex protein, metaxin [IPR017410]", "Mitochondrial phosphate carrier protein Pic2/Mir1-like [IPR044677]", "Mitochondrial processing peptidase subunit beta [IPR037718]", "Mitochondrial ribonuclease P catalytic subunit [IPR033495]", "Mitochondrial ribosomal protein L48 [IPR027487]", "Mitochondrial-processing peptidase subunit alpha [IPR037715]", "Mitofusin family [IPR027094]", "Mitofusin-1 [IPR027088]", "Mitofusin-2 [IPR027089]", "Mitogen-activated protein (MAP) kinase phosphatase [IPR008343]", "Mitotic spindle checkpoint protein Bub1/Mad3 [IPR015661]", "Monocarboxylate transporter 1 [IPR030757]", "Monocarboxylate transporter [IPR004743]", "Monothiol glutaredoxin-related [IPR004480]", "Mortality factor 4-like protein 1 [IPR038011]", "Mpv17/PMP22 [IPR007248]", "Mrp/NBP35 ATP-binding protein [IPR019591]", "Multidrug resistance protein 1 [IPR030258]", "Multiple myeloma tumor-associated protein 2-like [IPR039207]", "Myelin expression factor 2 [IPR034632]", "Myo-inositol-1-phosphate synthase [IPR002587]", "Myotubularin family [IPR030564]", "Myotubularin-related protein 6 [IPR030581]", "Myristoyl-CoA:protein N-myristoyltransferase [IPR000903]", "Myristoylated alanine-rich C-kinase substrate MARCKS [IPR002101]", "N-acetyl-D-glucosamine kinase NAGK-like [IPR039758]", "N-acetylglucosamine-6-sulfatase [IPR012251]", "N-acetylglucosamine-6-sulfatase, metazoan [IPR015981]", "N-acetyltransferase B complex, non-catalytic subunit [IPR019183]", "N-alpha-acetyltransferase 40 [IPR039949]", "N-terminal acetyltransferase A, auxiliary subunit [IPR021183]", "NAD kinase 2, mitochondrial [IPR012355]", "NAD kinase [IPR002504]", "NAD(P) transhydrogenase, alpha subunit [IPR026255]", "NAD(P)H-quinone oxidoreductase subunit D/H [IPR022885]", "NAD/FAD transporter SLC25A32-like [IPR044712]", "NADH dehydrogenase, subunit C [IPR010218]", "NADH ubiquinone oxidoreductase, F subunit [IPR011537]", "NADH-quinone oxidoreductase subunit E-like [IPR002023]", "NADH-ubiquinone oxidoreductase, 20 Kd subunit [IPR006138]", "NADH-ubiquinone reductase complex 1 MLRQ subunit [IPR010530]", "NADH:cytochrome b5 reductase-like [IPR001834]", "NADH:ubiquinone oxidoreductase, ESSS subunit [IPR019329]", "NADH:ubiquinone oxidoreductase, subunit G [IPR010228]", "NADH:ubiquinone oxidoreductase, subunit NDUFB4 [IPR009866]", "NADPH-cytochrome P450 reductase [IPR023208]", "NDRG [IPR004142]", "NEDD8 ultimate buster 1 [IPR039749]", "NEDD8-activating enzyme E1 catalytic subunit [IPR030468]", "NOL6/Upt22 [IPR005554]", "NPC1-like [IPR004765]", "NSF attachment protein [IPR000744]", "Na(+)/H(+) exchange regulatory cofactor NHERF-1 [IPR031199]", "Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 [IPR017300]", "Nck-associated protein 1 [IPR019137]", "Nectin-2 [IPR033318]", "Nesprin-2 [IPR030266]", "Nestin [IPR031211]", "Neurofilament light polypeptide [IPR027692]", "Neurofilament medium polypeptide [IPR027697]", "Neuroplastin [IPR027112]", "Neutral amino acid SLC6 transporter [IPR002438]", "Nicalin [IPR016574]", "Nicastrin [IPR008710]", "Nicotinamide phosphoribosyl transferase [IPR016471]", "Nitric oxide synthase-interacting protein [IPR016818]", "Nonaspanin (TM9SF) [IPR004240]", "Nonsense-mediated mRNA decay protein 3 [IPR039722]", "Not2/Not3/Not5 [IPR040168]", "Nuclear RNA export factor [IPR030217]", "Nuclear cap-binding protein subunit 1 [IPR027159]", "Nuclear factor hnRNPA1 [IPR021662]", "Nuclear fragile X mental retardation-interacting protein 2 [IPR032747]", "Nuclear mitotic apparatus protein 1 [IPR026650]", "Nuclear polyadenylated RNA-binding protein Nab2/ZC3H14 [IPR040366]", "Nuclear pore complex protein NUP98-NUP96 [IPR037637]", "Nuclear pore complex protein Nup133-like [IPR037624]", "Nuclear pore complex protein [IPR026054]", "Nuclear pore glycoprotein p62, metazoa [IPR033072]", "Nuclear pore membrane glycoprotein 210-like [IPR045197]", "Nuclear pore protein 84/107 [IPR007252]", "Nuclear protein localization protein 4 [IPR016563]", "Nuclear transport factor 2/Mtr2 [IPR045875]", "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 [IPR026633]", "Nucleobindin [IPR040250]", "Nucleobindin-1 [IPR040253]", "Nucleobindin-2 [IPR028813]", "Nucleolar GTP-binding protein 1 [IPR024926]", "Nucleolar GTP-binding protein 2 [IPR024929]", "Nucleolar and spindle-associated protein 1 [IPR026756]", "Nucleolar complex protein 2 [IPR005343]", "Nucleolar complex protein 4 [IPR027193]", "Nucleolar complex-associated protein 3 [IPR016903]", "Nucleolar protein 11 [IPR042859]", "Nucleolar protein 7 [IPR039626]", "Nucleolar protein Nop56/Nop58 [IPR045056]", "Nucleolar, Nop52 [IPR010301]", "Nucleoplasmin family [IPR004301]", "Nucleoporin NSP1/NUP62 [IPR026010]", "Nucleoporin NUP88/NUP82 [IPR037700]", "Nucleoporin Nup120/160 [IPR021717]", "Nucleoporin Nup186/Nup192/Nup205 [IPR021827]", "Nucleoporin Nup188 [IPR044840]", "Nucleoporin Nup37 [IPR037626]", "Nucleoporin Nup54/Nup57/Nup44 [IPR024864]", "Nucleoporin Nup85-like [IPR011502]", "Nucleoporin Nup88 [IPR019321]", "Nucleoporin Seh1 [IPR037597]", "Nucleoporin interacting component Nup93/Nic96 [IPR007231]", "Nucleoporin peptidase S59-like [IPR037665]", "Nucleoporin protein Ndc1-Nup [IPR019049]", "Nucleoporin, NUP53 [IPR017389]", "Nucleoporin, Nup155-like [IPR004870]", "Nucleoside 2-deoxyribosyltransferase [IPR007710]", "Nucleoside diphosphate kinase [IPR001564]", "Nucleoside-triphosphatase, THEP1 type [IPR004948]", "Nucleosome assembly protein (NAP) [IPR002164]", "Nucleosome-remodeling factor subunit BPTF [IPR038028]", "NudC domain-containing protein 1 [IPR037895]", "NudC family [IPR037898]", "OBG-type GTPase [IPR045086]", "OCIA domain-containing protein 1/2 [IPR040187]", "Occludin [IPR002958]", "Oligoribonuclease [IPR022894]", "Oligosaccharyl transferase complex, subunit OST3/OST6 [IPR021149]", "Oligosaccharyl transferase, STT3 subunit [IPR003674]", "Optic atrophy 3-like [IPR010754]", "Ornithine aminotransferase [IPR010164]", "Orotate phosphoribosyltransferase [IPR023031]", "Orotidine 5'-phosphate decarboxylase [IPR014732]", "Oxidized purine nucleoside triphosphate [IPR003563]", "Oxysterol-binding protein [IPR000648]", "P-type ATPase [IPR001757]", "P-type ATPase subfamily IIC, subunit alpha [IPR005775]", "P-type ATPase, subfamily IIA, SERCA-type [IPR005782]", "P-type ATPase, subfamily V [IPR006544]", "P-type ATPase, subfamily IIB [IPR006408]", "PA2G4 family [IPR004545]", "PAT complex subunit CCDC47 [IPR012879]", "PDCD5-like [IPR002836]", "PDK/BCKDK protein kinase [IPR039028]", "PDZ and LIM domain protein 1 [IPR028537]", "PEST proteolytic signal-containing nuclear protein [IPR029169]", "PH-interacting protein [IPR028738]", "PHF5-like [IPR005345]", "PITH domain-containing protein 1-like [IPR045099]", "Pachytene checkpoint protein 2-like [IPR044539]", "Palmitoyl protein thioesterase [IPR002472]", "Palmitoyl-protein thioesterase 1 [IPR030294]", "Pantothenate kinase, acetyl-CoA regulated, two-domain type [IPR015844]", "Paraneoplastic encephalomyelitis antigen [IPR002343]", "Paraoxonase2 [IPR008364]", "Pentatricopeptide repeat domain-containing protein 3 [IPR037387]", "Peptidase A22B, signal peptide peptidase [IPR007369]", "Peptidase C13, legumain [IPR001096]", "Peptidase C1B, bleomycin hydrolase [IPR004134]", "Peptidase C2, calpain family [IPR022684]", "Peptidase C26 [IPR011697]", "Peptidase C26, gamma-glutamyl hydrolase [IPR015527]", "Peptidase C54 [IPR005078]", "Peptidase C65, otubain [IPR019400]", "Peptidase C69, dipeptidase A [IPR005322]", "Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930]", "Peptidase M1, aminopeptidase B [IPR015571]", "Peptidase M13 [IPR000718]", "Peptidase M14B, caboxypeptidase D [IPR015567]", "Peptidase M17, leucine aminopeptidase [IPR023042]", "Peptidase M17, leucine aminopeptidase/peptidase B [IPR011356]", "Peptidase M20 [IPR002933]", "Peptidase M24, methionine aminopeptidase [IPR001714]", "Peptidase M24A, methionine aminopeptidase, subfamily 2 [IPR002468]", "Peptidase M3A/M3B [IPR045090]", "Peptidase S10, serine carboxypeptidase [IPR001563]", "Peptidase S1C [IPR001940]", "Peptidase S26B [IPR001733]", "Peptidase S28 [IPR008758]", "Peptidase S8, subtilisin-related [IPR015500]", "Peptidase S9A, prolyl oligopeptidase [IPR002470]", "Peptidase T1A, proteasome beta-subunit [IPR000243]", "Peptidase T2, asparaginase 2 [IPR000246]", "Peptidase family M49 [IPR039461]", "Peptidase, FtsH [IPR005936]", "Peptide chain release factor eRF1/aRF1 [IPR004403]", "Peptidyl-prolyl cis-trans isomerase FKBP2/11 [IPR044609]", "Peptidyl-prolyl cis-trans isomerase FKBP3 [IPR043368]", "Peptidyl-prolyl cis-trans isomerase FKBP4 [IPR031212]", "Peptidyl-prolyl cis-trans isomerase FKBP5 [IPR031210]", "Peptidyl-prolyl cis-trans isomerase PIN4 [IPR043323]", "Peptidyl-tRNA hydrolase, PTH2 [IPR002833]", "Pericentriolar material 1 protein [IPR024138]", "Perilipin [IPR004279]", "Periodic tryptophan protein 1 [IPR044285]", "Periodic tryptophan protein 2 [IPR027145]", "Peroxiredoxin, AhpC-type [IPR024706]", "Peroxiredoxin-5-like [IPR037944]", "Peroxisomal acyl-coenzyme A oxidase [IPR034171]", "Peroxisomal membrane protein 14 [IPR025655]", "Peroxysomal long chain fatty acyl transporter [IPR005283]", "Pescadillo [IPR010613]", "Phenylalanine-tRNA ligase, class IIc, beta subunit [IPR045060]", "Phenylalanyl-tRNA synthetase, class IIc, alpha subunit [IPR004529]", "Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archael/eukaryotic type [IPR004531]", "Phosducin-like [IPR045037]", "Phosphatidate cytidylyltransferase, mitochondrial [IPR015222]", "Phosphatidyl serine synthase [IPR004277]", "Phosphatidylethanolamine-binding protein [IPR008914]", "Phosphatidylethanolamine-binding protein, eukaryotic [IPR035810]", "Phosphatidylinositol kinase [IPR015433]", "Phosphatidylinositol transfer protein [IPR001666]", "Phosphatidylinositol-binding clathrin assembly protein [IPR030412]", "Phosphatidylinositol-glycan biosynthesis class S protein [IPR019540]", "Phosphatidylserine decarboxylase [IPR033177]", "Phosphatidylserine decarboxylase, eukaryotic type 1 [IPR033661]", "Phosphatidylserine decarboxylase-related [IPR003817]", "Phosphoacetylglucosamine mutase [IPR016657]", "Phosphodiesterase MJ0936/Vps29 [IPR000979]", "Phosphoglucomutase [IPR045244]", "Phosphoglucose isomerase (PGI) [IPR001672]", "Phosphoglycerate kinase [IPR001576]", "Phosphoglycerate mutase 1 [IPR005952]", "Phospholipase B-like [IPR007000]", "Phosphoribosylformylglycinamidine cyclo-ligase [IPR004733]", "Phosphoribosylformylglycinamidine synthase PurL [IPR010073]", "Phosphoribosylglycinamide formyltransferase [IPR004607]", "Phosphoribosylglycinamide synthetase [IPR000115]", "Phosphorylated adapter RNA export protein [IPR039047]", "Phosphoserine aminotransferase [IPR022278]", "Phosphotyrosyl phosphatase activator, PTPA [IPR004327]", "Pinin [IPR039853]", "Pirin [IPR012093]", "Plakin [IPR043197]", "Plakophilin/Delta catenin [IPR028435]", "Plasma membrane calcium-transporting ATPase 1 [IPR030320]", "Plasminogen activator inhibitor 1 RNA-binding protein [IPR027205]", "Plastin-1 [IPR030235]", "Plastin-2/3 [IPR039956]", "Plectin [IPR030269]", "Polo kinase kinase [IPR022165]", "Poly(A) polymerase [IPR014492]", "Poly(ADP-ribose) glycohydrolase [IPR007724]", "Poly-U binding splicing factor, PUF60-like [IPR006532]", "Polyadenylate binding protein, human types 1, 2, 3, 4 [IPR006515]", "Polyadenylate-binding protein 2 [IPR034911]", "Polyprenyl synthetase [IPR000092]", "Polyribonucleotide 5-hydroxyl-kinase Clp1/Grc3 [IPR045116]", "Polyribonucleotide nucleotidyltransferase [IPR012162]", "Porin, eukaryotic type [IPR001925]", "Pre-mRNA 3' end processing protein Pfs2-like [IPR045245]", "Pre-mRNA-processing factor 19 [IPR038959]", "Pre-mRNA-processing factor 6/Prp1/STA1 [IPR027108]", "Pre-mRNA-processing factor Prp40 [IPR039726]", "Pre-mRNA-processing-splicing factor 8 [IPR027652]", "Pre-mRNA-splicing factor Cwf15/Cwc15 [IPR006973]", "Pre-mRNA-splicing factor 38 [IPR005037]", "Pre-mRNA-splicing factor Cwc2/Slt11 [IPR039171]", "Pre-mRNA-splicing factor SPF27 [IPR008409]", "Pre-mRNA-splicing factor Syf1-like [IPR045075]", "Pre-rRNA-processing protein Esf1 [IPR039754]", "Pre-rRNA-processing protein PNO1-like [IPR039912]", "Prefoldin alpha subunit, archaea-type [IPR011599]", "Prefoldin alpha-like [IPR004127]", "Prefoldin beta-like [IPR002777]", "Prefoldin subunit 2 [IPR027235]", "Prefoldin subunit 3 [IPR016655]", "Prenylated rab acceptor PRA1 [IPR004895]", "Prenylcysteine oxidase [IPR017046]", "Prenyltransferase subunit beta [IPR045089]", "Presenilin/signal peptide peptidase [IPR006639]", "Primosome PriB/single-strand DNA-binding [IPR000424]", "Probable ubiquitin carboxyl-terminal hydrolase FAF-X [IPR031226]", "Profilin [IPR005455]", "Profilin-1 [IPR029892]", "Profilin-2 [IPR029891]", "Profilin1/2/3, vertebrate [IPR005454]", "Programmed cell death protein 4 [IPR039778]", "Prohibitin [IPR000163]", "Proliferating cell nuclear antigen, PCNA [IPR000730]", "Proline-rich AKT1 substrate 1 protein [IPR026682]", "Proline-rich protein PRCC [IPR018800]", "Proline-tRNA ligase, class IIa, archaeal-type [IPR004499]", "Prolyl 3-hydroxylase 1 [IPR039837]", "Prolyl 3-hydroxylase [IPR039575]", "Prolyl 4-hydroxylase [IPR045054]", "Prostaglandin E synthase 2 [IPR034334]", "Prostaglandin reductase 2 [IPR037399]", "Proteasomal ubiquitin receptor Rpn13/ADRM1 [IPR006773]", "Proteasome B-type subunit [IPR023333]", "Proteasome activator PA28 [IPR009077]", "Proteasome activator complex subunit 4 [IPR035309]", "Proteasome alpha-type subunit [IPR023332]", "Proteasome assembly chaperone 1 [IPR016565]", "Proteasome assembly chaperone 2 [IPR019151]", "Proteasome assembly chaperone 2, eukaryotic [IPR016562]", "Proteasome assembly chaperone 3 [IPR018788]", "Proteasome beta 3 subunit [IPR033811]", "Proteasome component Ecm29 [IPR024372]", "Proteasome subunit alpha 1 [IPR035144]", "Proteasome subunit alpha 3 [IPR037555]", "Proteasome subunit alpha 7 [IPR035190]", "Proteasome subunit alpha2 [IPR034644]", "Proteasome subunit alpha4 [IPR034647]", "Proteasome subunit alpha5 [IPR033812]", "Proteasome subunit alpha6 [IPR034642]", "Proteasome subunit beta 1 [IPR035202]", "Proteasome subunit beta 2 [IPR035206]", "Proteasome subunit beta 4 [IPR016295]", "Proteasome subunit beta 5 [IPR037558]", "Proteasome subunit beta 6 [IPR035140]", "Proteasome subunit beta 7 [IPR035216]", "Proteasome, subunit alpha/beta [IPR001353]", "Protein AATF/Bfr2 [IPR039223]", "Protein BRAWNIN [IPR027858]", "Protein CIP2A [IPR042510]", "Protein CUSTOS [IPR026694]", "Protein Cms1 [IPR032704]", "Protein DEK [IPR044198]", "Protein ERGIC-53 [IPR033085]", "Protein FAM8A1 [IPR039871]", "Protein FRG1 [IPR010414]", "Protein ICln/Lot5/Saf5 [IPR039924]", "Protein LYRIC [IPR031402]", "Protein Lsm12-like [IPR039683]", "Protein NDRG3 [IPR030692]", "Protein PBDC1, metazoa/fungi [IPR008476]", "Protein PRRC2 [IPR033184]", "Protein Peter Pan-like [IPR045112]", "Protein RCC2 [IPR028641]", "Protein Red-like [IPR039896]", "Protein S100-A10 [IPR028476]", "Protein S100-A11 [IPR028482]", "Protein SON [IPR032922]", "Protein Sgt1-like [IPR044563]", "Protein TFG [IPR033512]", "Protein XRP2 [IPR039093]", "Protein arginine N-methyltransferase PRMT5 [IPR007857]", "Protein arginine N-methyltransferase [IPR025799]", "Protein arginine methyltransferase NDUFAF7 [IPR003788]", "Protein canopy homolog [IPR042415]", "Protein disulfide-isomerase A6-like [IPR044569]", "Protein disulphide isomerase [IPR005792]", "Protein disulphide-isomerase A4 [IPR017068]", "Protein farnesyltransferase subunit beta [IPR026872]", "Protein flightless-1 [IPR029919]", "Protein import receptor MAS20 [IPR002056]", "Protein import receptor MAS20, metazoan [IPR022422]", "Protein kinase C and casein kinase substrate in neurons protein 2 [IPR028521]", "Protein kinase Mps1 family [IPR027084]", "Protein of unknown function DUF1075 [IPR009432]", "Protein of unknown function DUF2046 [IPR019152]", "Protein of unknown function DUF719 [IPR007998]", "Protein patched/dispatched [IPR003392]", "Protein phosphatase 2A regulatory subunit PR55 [IPR000009]", "Protein phosphatase 2A, regulatory B subunit, B56 [IPR002554]", "Protein phosphatase 2C family [IPR015655]", "Protein phosphatase methylesterase, eukaryotic [IPR016812]", "Protein regulator of cytokinesis 1 [IPR032921]", "Protein transport Sec61-beta/Sbh [IPR030671]", "Protein transport protein SEC31-like [IPR040251]", "Protein transport protein Sec23 [IPR037364]", "Protein transport protein SecG/Sec61-beta/Sbh [IPR016482]", "Protein virilizer [IPR026736]", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase [IPR000682]", "Protein-S-isoprenylcysteine O-methyltransferase [IPR025770]", "Protein-glutamate O-methyltransferase [IPR039763]", "Protein-tyrosine phosphatase, low molecular weight [IPR017867]", "Protein-tyrosine phosphatase, low molecular weight, mammalian [IPR002115]", "Protein-tyrosine phosphatase, non-receptor type-1/2 [IPR012265]", "Protein-tyrosine phosphatase-like, PTPLA [IPR007482]", "Protein/nucleic acid deglycase DJ-1 [IPR006287]", "Proteinase inhibitor I25A, stefin [IPR001713]", "Pseudouridine synthase I, TruA [IPR001406]", "Pseudouridine synthase PUS1/ PUS2-like [IPR041708]", "Pseudouridine synthase, TruD [IPR001656]", "Pumilio homologue 3 [IPR040059]", "Purine 5'-nucleotidase [IPR016695]", "Purine nucleoside phosphorylase I, inosine/guanosine-specific [IPR011270]", "Purine nucleoside phosphorylase [IPR011268]", "Purine-rich element binding protein family [IPR006628]", "Purine-rich element-binding protein alpha [IPR030500]", "Putative peptidyl-tRNA hydrolase PTRHD1 [IPR042237]", "Pyridine nucleotide-disulphide oxidoreductase, class I [IPR001100]", "Pyridoxal phosphate-dependent decarboxylase [IPR002129]", "Pyrimidine 5'-nucleotidase, eukaryotic [IPR006434]", "Pyrroline-5-carboxylate reductase [IPR000304]", "Pyruvate carboxylase [IPR005930]", "Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y [IPR017597]", "Pyruvate dehydrogenase E1 component subunit beta [IPR027110]", "Pyruvate kinase [IPR001697]", "RAD3/XPD family [IPR001945]", "RAD51-associated protein 1 [IPR026632]", "RINT-1/Tip20 [IPR007528]", "RLI1 [IPR013283]", "RNA (C5-cytosine) methyltransferase [IPR023267]", "RNA (C5-cytosine) methyltransferase, NOP2 [IPR023273]", "RNA 3'-terminal phosphate cyclase [IPR000228]", "RNA 3'-terminal phosphate cyclase type 2 [IPR016443]", "RNA binding protein HABP4/SERBP1 [IPR039764]", "RNA cytidine acetyltransferase NAT10 [IPR033688]", "RNA demethylase ALKBH5 [IPR032860]", "RNA exonuclease 4 [IPR034920]", "RNA polymerase I associated factor, A49-like [IPR009668]", "RNA polymerase II associated factor Paf1 [IPR007133]", "RNA polymerase II subunit A [IPR006811]", "RNA polymerase II transcription factor SIII, subunit A [IPR010684]", "RNA polymerase II transcriptional coactivator Sub1/Tcp4-like [IPR045125]", "RNA polymerase subunit Rpb7-like [IPR045113]", "RNA transcription, translation and transport factor protein [IPR019265]", "RNA-binding motif protein 8 [IPR008111]", "RNA-binding protein 10 [IPR033095]", "RNA-binding protein 26 [IPR034861]", "RNA-binding protein 26/27 [IPR045137]", "RNA-binding protein 45 [IPR033101]", "RNA-binding protein 5 [IPR033094]", "RNA-binding protein EWS [IPR033109]", "RNA-binding protein FUS [IPR034459]", "RNA-binding protein NOB1 [IPR039907]", "RNA-induced silencing complex, nuclease component Tudor-SN [IPR016685]", "RNA-splicing ligase RtcB homologue, eukaryotic [IPR027513]", "RNA-splicing ligase, RtcB [IPR001233]", "RNase P subunit p30 [IPR002738]", "RPA-related protein RADX [IPR040893]", "RZZ complex, subunit Zw10 [IPR009361]", "Rab GDI protein [IPR000806]", "Rab GTPase-activating protein 1 [IPR033185]", "Rab-like protein 6 [IPR040385]", "Rab24 [IPR041828]", "Rab35 [IPR041815]", "Rab3GAP catalytic subunit [IPR045700]", "Rab3GAP regulatory subunit [IPR026059]", "Rad21/Rec8-like protein [IPR039781]", "Ragulator complex protein LAMTOR2-like [IPR037587]", "RalBP1-associated Eps domain-containing protein 1 [IPR026814]", "Ran GTPase [IPR002041]", "Ran binding protein RanBP1-like [IPR045255]", "Ras GTPase GNL1-like [IPR043358]", "Ras GTPase-activating protein-binding protein 1 [IPR034375]", "Ras GTPase-activating protein-binding protein 2 [IPR034377]", "Ras GTPase-activating protein-binding protein [IPR039539]", "Ras-related protein Rab14 [IPR030702]", "Ras-related protein Ral [IPR028412]", "Reduced folate carrier [IPR002666]", "Reduced folate transporter SLC19A1 [IPR028339]", "Remodeling and spacing factor 1-like [IPR028938]", "Remodelling complex subunit Rsc/polybromo [IPR037382]", "Replication factor A protein 1 [IPR004591]", "Replication factor A protein 3 [IPR013970]", "Replication factor C subunit 1 [IPR012178]", "Reticulon-4-interacting protein 1 [IPR037397]", "Retrieval of early ER protein Rer1 [IPR004932]", "Rho protein GDP-dissociation inhibitor [IPR000406]", "Rho-associated protein kinase 1/2 [IPR020684]", "Rho-related GTP-binding protein RhoG [IPR042734]", "Ribonuclease CAF1 [IPR006941]", "Ribonuclease H2, subunit A [IPR004649]", "Ribonuclease HII/HIII [IPR001352]", "Ribonuclease III [IPR011907]", "Ribonuclease Nob1, eukaryote [IPR017117]", "Ribonuclease T2, eukaryotic [IPR033697]", "Ribonuclease T2-like [IPR001568]", "Ribonucleases P/MRP protein subunit Pop1 [IPR039182]", "Ribonucleoprotein PTB-binding 1 [IPR034635]", "Ribonucleoside-diphosphate reductase large subunit [IPR039718]", "Ribonucleotide reductase small subunit [IPR033909]", "Ribonucleotide reductase small subunit family [IPR000358]", "Ribophorin I [IPR007676]", "Ribose-phosphate pyrophosphokinase [IPR005946]", "Ribosomal RNA adenine dimethylase [IPR011530]", "Ribosomal RNA adenine methyltransferase KsgA/Erm [IPR001737]", "Ribosomal RNA assembly KRR1 [IPR024166]", "Ribosomal RNA large subunit methyltransferase E [IPR015507]", "Ribosomal RNA processing protein 8 [IPR007823]", "Ribosomal RNA-processing protein 15 [IPR012459]", "Ribosomal RNA-processing protein 7 [IPR040446]", "Ribosomal RNA-processing protein Rrp9-like [IPR039241]", "Ribosomal biogenesis NSA2 family [IPR039411]", "Ribosomal biogenesis regulatory protein [IPR007023]", "Ribosomal biogenesis, methyltransferase, EMG1/NEP1 [IPR005304]", "Ribosomal protein L1 [IPR002143]", "Ribosomal protein L1, mitochondrial [IPR005879]", "Ribosomal protein L1/ribosomal biogenesis protein [IPR028364]", "Ribosomal protein L10P [IPR001790]", "Ribosomal protein L10e [IPR001197]", "Ribosomal protein L11, bacterial-type [IPR006519]", "Ribosomal protein L11/L12 [IPR000911]", "Ribosomal protein L12/P1/P2 family [IPR027534]", "Ribosomal protein L13 [IPR005822]", "Ribosomal protein L13, eukaryotic/archaeal [IPR005755]", "Ribosomal protein L13e [IPR001380]", "Ribosomal protein L14 [IPR039660]", "Ribosomal protein L14P [IPR000218]", "Ribosomal protein L15 [IPR030878]", "Ribosomal protein L15, bacterial-type [IPR005749]", "Ribosomal protein L15e [IPR000439]", "Ribosomal protein L18e [IPR000039]", "Ribosomal protein L19 [IPR001857]", "Ribosomal protein L2 [IPR002171]", "Ribosomal protein L2, archaeal-type [IPR023672]", "Ribosomal protein L21 [IPR001787]", "Ribosomal protein L21-like [IPR028909]", "Ribosomal protein L21e [IPR001147]", "Ribosomal protein L22/L17 [IPR001063]", "Ribosomal protein L22/L17, eukaryotic/archaeal [IPR005721]", "Ribosomal protein L22e [IPR002671]", "Ribosomal protein L23 [IPR019985]", "Ribosomal protein L24 [IPR003256]", "Ribosomal protein L24e-related [IPR000988]", "Ribosomal protein L25/L23 [IPR013025]", "Ribosomal protein L27e [IPR001141]", "Ribosomal protein L28/L24 [IPR026569]", "Ribosomal protein L28e [IPR002672]", "Ribosomal protein L29/L35 [IPR001854]", "Ribosomal protein L29e [IPR002673]", "Ribosomal protein L3 [IPR000597]", "Ribosomal protein L3, archaeal/eukaryotic type [IPR045077]", "Ribosomal protein L3, bacterial/organelle-type [IPR019927]", "Ribosomal protein L30/YlxQ [IPR039109]", "Ribosomal protein L30e [IPR000231]", "Ribosomal protein L31e [IPR000054]", "Ribosomal protein L32e [IPR001515]", "Ribosomal protein L34Ae [IPR008195]", "Ribosomal protein L35A [IPR001780]", "Ribosomal protein L36e [IPR000509]", "Ribosomal protein L37/S30 [IPR010793]", "Ribosomal protein L37ae [IPR002674]", "Ribosomal protein L37e [IPR001569]", "Ribosomal protein L38e [IPR002675]", "Ribosomal protein L4, eukaryotic and archaeal type [IPR045240]", "Ribosomal protein L4/L1e [IPR002136]", "Ribosomal protein L44e [IPR000552]", "Ribosomal protein L47, mitochondrial [IPR010729]", "Ribosomal protein L5 [IPR002132]", "Ribosomal protein L5 eukaryotic/L18 archaeal [IPR005485]", "Ribosomal protein L53, mitochondrial [IPR019716]", "Ribosomal protein L6 [IPR000702]", "Ribosomal protein L7, eukaryotic [IPR005998]", "Ribosomal protein L7/L12 [IPR000206]", "Ribosomal protein L7/L30 [IPR039699]", "Ribosomal protein L7A/L8 [IPR001921]", "Ribosomal protein L7Ae/L8/Nhp2 family [IPR018492]", "Ribosomal protein L9 [IPR000244]", "Ribosomal protein P2 [IPR044076]", "Ribosomal protein S10 [IPR001848]", "Ribosomal protein S10, eukaryotic/archaeal [IPR005729]", "Ribosomal protein S11 [IPR001971]", "Ribosomal protein S12/S23 [IPR006032]", "Ribosomal protein S12e [IPR000530]", "Ribosomal protein S13 [IPR001892]", "Ribosomal protein S15 [IPR000589]", "Ribosomal protein S15P [IPR023029]", "Ribosomal protein S17, archaeal/eukaryotic [IPR028333]", "Ribosomal protein S17/S11 [IPR000266]", "Ribosomal protein S17e [IPR001210]", "Ribosomal protein S19/S15 [IPR002222]", "Ribosomal protein S19A/S15e [IPR005713]", "Ribosomal protein S19e [IPR001266]", "Ribosomal protein S2 [IPR001865]", "Ribosomal protein S2, bacteria/mitochondria/plastid [IPR005706]", "Ribosomal protein S2, eukaryotic [IPR027498]", "Ribosomal protein S2, eukaryotic/archaeal [IPR005707]", "Ribosomal protein S21e [IPR001931]", "Ribosomal protein S22, mitochondrial [IPR019374]", "Ribosomal protein S23, eukaryotic/archaeal [IPR005680]", "Ribosomal protein S23, mitochondrial [IPR019520]", "Ribosomal protein S23/S29, mitochondrial [IPR019368]", "Ribosomal protein S24/S35, mitochondrial [IPR039848]", "Ribosomal protein S24e [IPR001976]", "Ribosomal protein S25 [IPR004977]", "Ribosomal protein S28e [IPR000289]", "Ribosomal protein S29, mitochondrial [IPR008092]", "Ribosomal protein S3, eukaryotic/archaeal [IPR005703]", "Ribosomal protein S30 [IPR006846]", "Ribosomal protein S30, mitochondrial [IPR039982]", "Ribosomal protein S3Ae [IPR001593]", "Ribosomal protein S4/S9 [IPR022801]", "Ribosomal protein S4/S9, eukaryotic/archaeal [IPR005710]", "Ribosomal protein S4e [IPR000876]", "Ribosomal protein S5 [IPR000851]", "Ribosomal protein S5, eukaryotic/archaeal [IPR005711]", "Ribosomal protein S5/S7 [IPR000235]", "Ribosomal protein S5/S7, eukaryotic/archaeal [IPR005716]", "Ribosomal protein S6 kinase II [IPR016239]", "Ribosomal protein S6, eukaryotic [IPR014401]", "Ribosomal protein S6e [IPR001377]", "Ribosomal protein S7e [IPR000554]", "Ribosomal protein S8 [IPR000630]", "Ribosomal protein S8e [IPR001047]", "Ribosomal protein S8e/ribosomal biogenesis NSA2 [IPR022309]", "Ribosomal protein S9 [IPR000754]", "Ribosome assembly factor Mrt4 [IPR033867]", "Ribosome biogenesis factor, NIP7 [IPR016686]", "Ribosome biogenesis protein BRX1 [IPR026532]", "Ribosome biogenesis protein Bms1/Tsr1 [IPR039761]", "Ribosome biogenesis protein Nop16 [IPR019002]", "Ribosome biogenesis protein Nop53/GLTSCR2 [IPR011687]", "Ribosome biogenesis protein Rpf2 [IPR039770]", "Ribosome maturation protein Sdo1/SBDS [IPR002140]", "Ribosome maturation protein Sdo1/SBDS-like [IPR039100]", "Ribosome recycling factor [IPR002661]", "Ribosome-binding ATPase YchF/Obg-like ATPase 1 [IPR004396]", "Ribosome-binding protein 1 [IPR040248]", "RuvB-like [IPR027238]", "RuvB-like helicase 1 [IPR037938]", "RuvB-like helicase 2 [IPR037942]", "S-adenosylmethionine synthetase [IPR002133]", "S-formylglutathione hydrolase [IPR014186]", "S-phase kinase-associated protein 1 [IPR016897]", "S-phase kinase-associated protein 1-like [IPR001232]", "SAP30-binding protein [IPR012479]", "SCAMP [IPR007273]", "SERRATE/Ars2 [IPR039727]", "SH3-binding, glutamic acid-rich protein [IPR006993]", "SIT4 phosphatase-associated protein family [IPR007587]", "SKI-interacting protein, SKIP [IPR017862]", "SLC12A transporter family [IPR004842]", "SNF5/SMARCB1/INI1 [IPR006939]", "SNU66/SART1 family [IPR005011]", "SOS response associated peptidase (SRAP) [IPR003738]", "SOUL haem-binding protein [IPR006917]", "SUMO-activating enzyme subunit Uba2 [IPR030661]", "SWI/SNF complex subunit BAF57 [IPR030089]", "SWI/SNF complex subunit BRG1 [IPR030100]", "SWI/SNF complex subunit SMARCC1 [IPR030087]", "SWI/SNF complex subunit SMARCC2 [IPR038044]", "SWI/SNF-like complex subunit BAF250a [IPR030094]", "SWI/SNF-like complex subunit BAF250/Osa [IPR021906]", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [IPR038041]", "Scaffold attachment factor B1 [IPR034781]", "Scaffold attachment factor B2 [IPR034782]", "Scavenger mRNA decapping enzyme DcpS/DCS2 [IPR008594]", "Scc2/Nipped-B family [IPR033031]", "Schlafen family [IPR029684]", "Sds3-like [IPR013907]", "Sec1-like protein [IPR001619]", "Sec13/Seh1 family [IPR037363]", "SecY/SEC61-alpha family [IPR002208]", "Selenophosphate synthetase [IPR004536]", "Sentrin-specific protease 3 [IPR037945]", "Sepiapterin reductase [IPR006393]", "Septin 2 [IPR008113]", "Septin 7 [IPR008115]", "Septin 9 [IPR030645]", "Septin [IPR016491]", "Serine hydroxymethyltransferase [IPR001085]", "Serine-tRNA ligase, type1 [IPR002317]", "Serine/arginine-rich splicing factor 10 [IPR034476]", "Serine/arginine-rich splicing factor 11 [IPR034447]", "Serine/arginine-rich splicing factor 2-like [IPR034893]", "Serine/threonine protein phosphatase 5 [IPR011236]", "Serine/threonine-protein kinase PAK2 [IPR035065]", "Serine/threonine-protein kinase TOR [IPR026683]", "Serine/threonine-protein phosphatase 2A subunit A, metazoa [IPR031090]", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit [IPR037979]", "Serpin H1 [IPR033547]", "Serpin family [IPR000215]", "Short transmembrane mitochondrial protein 1 [IPR027854]", "Short-chain dehydrogenase/reductase SDR [IPR002347]", "Sialidase family [IPR026856]", "Sigma intracellular receptor 2 [IPR016964]", "Signal peptidase complex catalytic subunit SEC11A [IPR037712]", "Signal peptidase complex subunit 3 [IPR007653]", "Signal peptidase complex subunit Spc2/SPCS2 [IPR009582]", "Signal recognition particle SRP9 [IPR039914]", "Signal recognition particle receptor, beta subunit [IPR019009]", "Signal recognition particle subunit SRP68 [IPR026258]", "Signal recognition particle, SRP14 subunit [IPR003210]", "Signal recognition particle, SRP19 subunit [IPR002778]", "Signal recognition particle, SRP54 subunit [IPR022941]", "Signal recognition particle, SRP54 subunit, eukaryotic [IPR006325]", "Signal recognition particle, SRP72 subunit [IPR026270]", "Signal recognition particle, SRP9 subunit [IPR008832]", "Sin3 associated polypeptide p18 [IPR010516]", "Single-stranded DNA-binding protein [IPR011344]", "Sirtuin family [IPR003000]", "Sirtuin, class I [IPR017328]", "Sister chromatid cohesion protein Pds5 [IPR039776]", "Ski3/TTC37 [IPR039226]", "Sm-like protein Lsm6/SmF [IPR016487]", "Smac/DIABLO protein [IPR015142]", "Small (40S) ribosomal subunit Asc1/RACK1 [IPR045223]", "Small GTPase Rho [IPR003578]", "Small GTPase [IPR001806]", "Small GTPase superfamily, ARF type [IPR024156]", "Small GTPase superfamily, ARF/SAR type [IPR006689]", "Small GTPase superfamily, SAR1-type [IPR006687]", "Small GTPase, Ras-type [IPR020849]", "Small nuclear ribonucleoprotein E [IPR027078]", "Small nuclear ribonucleoprotein Sm D2 [IPR027248]", "Small nuclear ribonucleoprotein Sm D3 [IPR034099]", "Small-subunit processome, Utp11 [IPR007144]", "Small-subunit processome, Utp14 [IPR006709]", "Smooth muscle protein/calponin [IPR003096]", "Snf7 family [IPR005024]", "Sodium/potassium-transporting ATPase subunit beta [IPR000402]", "Sodium/potassium-transporting ATPase subunit beta, chordates [IPR015565]", "Sodium:dicarboxylate symporter [IPR001991]", "Sodium:neurotransmitter symporter [IPR000175]", "Solute carrier family 12 member 1/2 [IPR002443]", "Solute carrier family 12 member 2 [IPR002444]", "Solute carrier family 35 member SLC35F1/F2/F6 [IPR009262]", "Sorting nexin 9 family [IPR014536]", "Sorting nexin-1 [IPR028660]", "Sorting nexin-2 [IPR028653]", "Sorting nexin-5/6/32 [IPR014637]", "Sorting nexin-6 [IPR028657]", "Sorting nexin-9 [IPR028644]", "Spartin-like [IPR045036]", "Spectrin, beta subunit [IPR016343]", "Spermatid perinuclear RNA-binding protein [IPR030446]", "Spermidine/spermine synthase, eukaryotes [IPR030668]", "Spermidine/spermine synthases [IPR001045]", "Sphingomyelin phosphodiesterase 4 [IPR024129]", "Sphingosine N-acyltransferase Lag1/Lac1-like [IPR016439]", "Splicing factor 3A subunit 1 [IPR045146]", "Splicing factor 3A subunit 3 [IPR031776]", "Splicing factor 3B subunit 1-like [IPR038737]", "Splicing factor 45 [IPR040052]", "Splicing factor ELAV/Hu [IPR006548]", "Splicing factor, RBM39-like [IPR006509]", "Splicing factor, arginine/serine-rich 19 [IPR042841]", "Squalene cyclase [IPR018333]", "Squalene monooxygenase [IPR040125]", "Squalene synthase-like [IPR006449]", "Squalene/phytoene synthase [IPR002060]", "Stathmin family [IPR000956]", "Steroidogenic acute regulatory protein-like [IPR000799]", "Sterol transport protein NPC2-like [IPR039670]", "Stomatin/HflK/HflC family [IPR001972]", "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 [IPR038892]", "Structural maintenance of chromosomes protein 1A, metazoan [IPR029683]", "Structural maintenance of chromosomes protein [IPR024704]", "Structure-specific recognition protein [IPR000969]", "Succinate dehydrogenase, flavoprotein subunit [IPR011281]", "Succinate dehydrogenase/fumarate reductase iron-sulphur protein [IPR004489]", "Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [IPR014006]", "Succinate semialdehyde dehydrogenase [IPR010102]", "Succinate--CoA synthetase, beta subunit [IPR005809]", "Succinyl-CoA ligase, alpha subunit [IPR005810]", "Sulfhydryl oxidase [IPR039798]", "Sulfotransferase [IPR005331]", "Sulfurtransferase TST/MPST-like [IPR045078]", "Suppressor of white apricot [IPR040397]", "Surface antigen D15-like [IPR039910]", "Surfeit locus 6 [IPR007019]", "Symplekin/Pta1 [IPR021850]", "Synaptobrevin [IPR001388]", "Synaptogyrin [IPR016579]", "Syntaxin [IPR045242]", "Synthesis of cytochrome c oxidase, Sco1/Sco2 [IPR017276]", "T-complex protein 1, alpha subunit [IPR012715]", "T-complex protein 1, beta subunit [IPR012716]", "T-complex protein 1, delta subunit [IPR012717]", "T-complex protein 1, epsilon subunit [IPR012718]", "T-complex protein 1, eta subunit [IPR012720]", "T-complex protein 1, gamma subunit [IPR012719]", "T-complex protein 1, theta subunit [IPR012721]", "T-complex protein 1, zeta subunit [IPR012722]", "TAF15/EWS/TLS family [IPR034870]", "TAP46-like protein [IPR007304]", "TATA binding associated factor 15 [IPR034875]", "TB2/DP1/HVA22-related protein [IPR004345]", "TCF25/Rqc1 [IPR006994]", "TH1 protein [IPR006942]", "THO complex subunit 2 [IPR040007]", "THO complex subunit 6 [IPR042626]", "THO complex, subunit THOC1 [IPR021861]", "THRAP3/BCLAF1 family [IPR029199]", "TIP41-like protein [IPR007303]", "TMEM192 family [IPR029399]", "TMEM33/Pom33 family [IPR005344]", "TMEM85/ER membrane protein complex subunit 4 [IPR009445]", "TOX high mobility group box family member 4 [IPR037985]", "TPX2 [IPR009675]", "TRAPP I complex, subunit 5 [IPR016696]", "TREX component Tex1/THOC3 [IPR040132]", "Tankyrase 1-binding protein-like [IPR040006]", "Target of Myb protein 1 [IPR014645]", "Taxilin family [IPR026183]", "Telomere-associated protein Rif1 [IPR028566]", "Testis-expressed protein 10/pre-rRNA-processing protein Ipi1 [IPR037947]", "Tetrahydrofolate dehydrogenase/cyclohydrolase [IPR000672]", "Tetraspanin, animals [IPR000301]", "Tetraspanin/Peripherin [IPR018499]", "Tetratricopeptide repeat protein 19 [IPR040395]", "Tetratricopeptide repeat protein 21A/21B [IPR040364]", "Tetratricopeptide repeat protein 26 [IPR030511]", "Tetratricopeptide repeat protein 38 [IPR033891]", "ThiF/MoeB/HesA family [IPR045886]", "Thiamine pyrophosphate enzyme [IPR045229]", "Thiolase [IPR002155]", "Thioredoxin domain-containing protein 17-like [IPR045108]", "Thioredoxin-related transmembrane protein 2 [IPR039101]", "Thioredoxin/glutathione reductase selenoprotein [IPR006338]", "Threonine-tRNA ligase, class IIa [IPR002320]", "Thymidine kinase [IPR001267]", "Thymidylate kinase [IPR018094]", "Thymidylate synthase [IPR000398]", "Thymidylate synthase/dCMP hydroxymethylase [IPR045097]", "Thyroid hormone receptor-associated protein 3 [IPR026667]", "Tight junction protein ZO [IPR005417]", "Tight junction protein ZO-1 [IPR005418]", "Tight junction protein ZO-2 [IPR005419]", "Tim23-like [IPR045238]", "Tim44-like [IPR039544]", "Timeless [IPR044998]", "TmcA/NAT10/Kre33 [IPR032672]", "Tom40 [IPR037930]", "Torsin-1A-interacting protein 1/2 [IPR008662]", "TraB/PrgY/GumN family [IPR002816]", "Trans-isoprenyl diphosphate synthases, eukaryotic-type [IPR044844]", "Transaldolase type 1 [IPR004730]", "Transaldolase/Fructose-6-phosphate aldolase [IPR001585]", "Transcription elongation factor SPT5 [IPR039659]", "Transcription elongation factor Spt5, eukaryote [IPR017071]", "Transcription elongation factor Spt6 [IPR017072]", "Transcription elongation factor, IIS-type [IPR035100]", "Transcription elongation factor, TFIIS [IPR006289]", "Transcription elongation regulator 1-like [IPR045148]", "Transcription facto Tfc3-like [IPR044210]", "Transcription factor BTF3 [IPR039370]", "Transcription factor E [IPR039997]", "Transcription factor II-I [IPR016659]", "Transcription factor IIIC subunit Tfc1/Sfc1 [IPR040454]", "Transcription factor STAT [IPR001217]", "Transcription factor Tfc4/TFIIIC-102/Sfc4 [IPR039340]", "Transcription factor, enhancer of yellow 2 [IPR018783]", "Transcription intermediary factor 1-beta [IPR037373]", "Transcriptional regulator TACO1-like [IPR002876]", "Transcriptional regulatory protein Sin3-like [IPR039774]", "Transcriptional regulatory protein Sin3a [IPR037969]", "Transcriptional repressor p66 [IPR040386]", "Transducin beta-like protein 2 [IPR042410]", "Transferrin receptor protein 1 [IPR029513]", "Transgelin-2 [IPR001061]", "Translation Initiation factor eIF- 4e [IPR001040]", "Translation elongation factor EF1A, eukaryotic/archaeal [IPR004539]", "Translation elongation factor EFG/EF2 [IPR004540]", "Translation elongation factor EFTs/EF1B [IPR001816]", "Translation elongation factor EFTu/EF1A, bacterial/organelle [IPR004541]", "Translation elongation factor IF5A-like [IPR001884]", "Translation initiation factor 2, alpha subunit [IPR011488]", "Translation initiation factor 2A [IPR011387]", "Translation initiation factor 3 complex subunit L [IPR019382]", "Translation initiation factor IF- 2 [IPR015760]", "Translation initiation factor IF2/IF5 [IPR045196]", "Translation initiation factor IF6 [IPR002769]", "Translation initiation factor aIF-2, bacterial-like [IPR000178]", "Translational activator Gcn1 [IPR033173]", "Translationally controlled tumour protein [IPR018105]", "Translin [IPR033956]", "Translin family [IPR002848]", "Translocation associated membrane protein [IPR016447]", "Translocation protein Sec63 [IPR027137]", "Translocon-associated [IPR008855]", "Translocon-associated protein (TRAP), alpha subunit [IPR005595]", "Transmembrane emp24 domain-containing protein 7 [IPR015718]", "Transmembrane emp24 domain-containing protein [IPR015720]", "Transmembrane protein 109 [IPR039492]", "Transmembrane protein 126 [IPR009801]", "Transmembrane protein 201 [IPR040041]", "Transmembrane protein 205 [IPR042623]", "Transmembrane protein 214 [IPR019308]", "Transmembrane protein 230 [IPR044234]", "Transmembrane protein 230/134 [IPR008590]", "Transmembrane protein 43 family [IPR012430]", "Transmembrane protein 65 [IPR019537]", "Transmembrane protein GPR107/GPR108-like [IPR009637]", "Transport protein particle (TRAPP) component [IPR007194]", "Treacle protein [IPR017859]", "Tricarboxylate/iron carrier [IPR004686]", "Triosephosphate isomerase [IPR000652]", "Triosephosphate isomerase, bacterial/eukaryotic [IPR022896]", "Tropomodulin [IPR004934]", "Tropomodulin-3 [IPR030133]", "Tropomyosin [IPR000533]", "Tryptophan-tRNA ligase [IPR002306]", "Tuberin [IPR003913]", "Tuberin/Ral GTPase-activating protein subunit alpha [IPR027107]", "Tubulin [IPR000217]", "Tubulin binding cofactor A [IPR004226]", "Tubulin--tyrosine ligase-like protein 12 [IPR027749]", "Tubulin-specific chaperone E [IPR044994]", "Tubulin-tyrosine ligase/Tubulin polyglutamylase [IPR004344]", "Tumour protein D52 [IPR007327]", "Tweety [IPR006990]", "Twinfilin [IPR028458]", "Type 1 protein exporter [IPR039421]", "Type II pantothenate kinase [IPR004567]", "Tyrosine-tRNA ligase [IPR002307]", "Tyrosine-tRNA ligase, bacterial-type [IPR024088]", "U1 small nuclear ribonucleoprotein C [IPR017340]", "U2 small nuclear ribonucleoprotein A' [IPR044640]", "U2 snRNP auxilliary factor, large subunit, splicing factor [IPR006529]", "U3 small nucleolar RNA-associated protein 10 [IPR040191]", "U3 small nucleolar RNA-associated protein 18 [IPR045161]", "U3 small nucleolar RNA-associated protein 25 [IPR010678]", "U3 small nucleolar RNA-associated protein 6 [IPR013949]", "U3 small nucleolar ribonucleoprotein complex, subunit Mpp10 [IPR012173]", "U4/U6 small nuclear ribonucleoprotein Prp3 [IPR027104]", "U4/U6 small nuclear ribonucleoprotein Prp31 [IPR027105]", "U6 snRNA-associated Sm-like protein LSm2 [IPR016654]", "UAA transporter [IPR013657]", "UBAP2/protein lingerer [IPR022166]", "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110kDa subunit [IPR037919]", "UDP-glucose 6-dehydrogenase, eukaryotic type [IPR028356]", "UDP-glucose/GDP-mannose dehydrogenase [IPR017476]", "UDP-glucose:Glycoprotein Glucosyltransferase [IPR009448]", "UDP-sugar pyrophosphorylase [IPR039741]", "UDPGP family [IPR002618]", "UHRF1/2-like [IPR045134]", "UMP-CMP kinase [IPR006266]", "USP39 [IPR033809]", "UTP--glucose-1-phosphate uridylyltransferase [IPR016267]", "UV excision repair protein Rad23 [IPR004806]", "Ubiquitin carboxyl-terminal hydrolase 10 [IPR028767]", "Ubiquitin carboxyl-terminal hydrolase 14-like [IPR044635]", "Ubiquitin conjugation factor E4 [IPR045132]", "Ubiquitin fusion degradation protein Ufd1-like [IPR004854]", "Ubiquitin thioesterase OTUB1 [IPR030298]", "Ubiquitin thioesterase Otubain [IPR016615]", "Ubiquitin-activating enzyme E1 [IPR018075]", "Ubiquitin-fold modifier-conjugating enzyme 1 [IPR014806]", "Ubiquitin-like modifier Hub1/Ubl5 [IPR039732]", "Ubiquitin-protein ligase E3B/C [IPR044611]", "Ubiquitin/SUMO-activating enzyme E1 [IPR000011]", "Ubiquitinyl hydrolase [IPR016652]", "Ubiquitinyl hydrolase, UCH37 type [IPR017390]", "Uncharacterized protein KIAA2013-like [IPR018795]", "Uracil-DNA glycosylase family 1 [IPR002043]", "Ureohydrolase [IPR006035]", "Uroporphyrinogen decarboxylase HemE [IPR006361]", "V-type ATPase, V0 complex, 116kDa subunit family [IPR002490]", "V-type ATP synthase catalytic alpha chain [IPR022878]", "V-type ATP synthase regulatory subunit B/beta [IPR022879]", "V-type ATPase subunit E [IPR002842]", "V0 complex accessory subunit Ac45 [IPR008388]", "Vacuolar protein sorting protein 26 related [IPR028934]", "Vacuolar protein sorting-associated protein 13 [IPR026847]", "Vacuolar protein sorting-associated protein 16 [IPR016534]", "Vacuolar protein sorting-associated protein 29 [IPR028661]", "Vacuolar protein sorting-associated protein 33 [IPR027121]", "Vacuolar protein sorting-associated protein 35 [IPR005378]", "Vacuolar protein sorting-associated protein 4 [IPR031255]", "Vacuolar protein sorting-associated protein 51 [IPR014812]", "Vacuolar protein sorting-associated protein 53 [IPR039766]", "Vacuolar protein sorting-associated protein 9-like [IPR045046]", "Vacuolar protein sorting-associated protein Ist1 [IPR005061]", "Vacuolar protein-sorting protein Bro1-like [IPR045251]", "Valine-tRNA ligase [IPR002303]", "Vesicle-associated membrane-protein-associated protein [IPR016763]", "Vesicle-fusing ATPase [IPR039812]", "Vesicle-trafficking protein Sec22 [IPR044565]", "Villin/Gelsolin [IPR007122]", "Vimentin [IPR027699]", "Vinculin [IPR017997]", "Vinculin/alpha-catenin [IPR006077]", "Vitamin K-dependent gamma-carboxylase [IPR007782]", "Voltage-dependent anion-selective channel protein 1 [IPR030270]", "Voltage-dependent anion-selective channel protein 2 [IPR030277]", "Voltage-dependent anion-selective channel protein 3 [IPR030271]", "WD repeat BOP1/Erb1 [IPR028598]", "WD repeat Prp46/PLRG1-like [IPR045241]", "WD repeat WDR12/Ytm1 [IPR028599]", "WD repeat-containing protein 11 [IPR039694]", "WD repeat-containing protein 91 [IPR039724]", "WD repeat-containing protein DCAF7-like [IPR045159]", "WD repeat-containing protein WDR18/Ipi3/RID3 [IPR045227]", "WD repeat-containing protein WDR46/Utp7 [IPR040315]", "WD40 repeat-containing protein SMU1 [IPR045184]", "WW domain binding protein 11 [IPR019007]", "Wings apart-like protein [IPR039874]", "Wolframin [IPR026208]", "Wolframin family [IPR026209]", "XMAP215 family [IPR045110]", "XPG/Rad2 endonuclease [IPR006084]", "Xaa-Arg dipeptidase [IPR017144]", "YAP-binding/ALF4/Glomulin [IPR013877]", "YEATS [IPR005033]", "YLP motif-containing protein 1 [IPR026314]", "YTH domain containing protein [IPR045168]", "YjeF N-terminal domain-containing protein NAXE-like [IPR032976]", "Zinc finger CCCH domain-containing protein A/B [IPR039691]", "Zinc finger CCHC domain-containing protein 3 [IPR042509]", "Zinc finger FYVE domain containing protein, SARA/endofin [IPR035438]", "Zinc finger FYVE domain-containing protein, endofin [IPR017165]", "Zinc finger Ran-binding domain-containing protein 2 [IPR017337]", "Zinc finger protein 532-like [IPR045914]", "Zinc finger protein 638 [IPR033096]", "cAMP-dependent protein kinase catalytic subunit [IPR044109]", "cAMP-dependent protein kinase regulatory subunit [IPR012198]", "dCTP pyrophosphatase 1 [IPR025984]", "hnRNP A2/B1 [IPR034489]", "mRNA 3'-end-processing protein Rna14-like [IPR045243]", "mRNA export factor GLE1-like [IPR012476]", "mRNA export factor Gle2/RAE1 [IPR037631]", "p53 tumour suppressor family [IPR002117]", "rRNA biogenesis protein Rrp5 [IPR045209]", "tRNA (C5-cytosine) methyltransferase, NCL1 [IPR023270]", "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 [IPR017423]", "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit [IPR028884]", "tRNA (guanine-N1-)-methyltransferase, eukaryotic [IPR007356]", "tRNA methyltransferase 10 homologue C [IPR025812]", "tRNA modification GTPase MnmE [IPR004520]", "tRNA pseudouridine synthase B family [IPR004802]", "tRNA-specific 2-thiouridylase [IPR004506]", "tRNAHis guanylyltransferase Thg1 [IPR007537]"], "available_proteins": ["AAAS", "AARS", "AARS2", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABHD12", "ABHD6", "ACAA2", "ACADM", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSL1", "ACTL6A", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR6", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFG3L2", "AGL", "AGPS", "AHCY", "AHCYL1", "AHSA1", "AIMP2", "AIP", "AK1", "AK2", "AK6", "AKAP12", "AKAP13", "AKAP17A", "AKAP8L", "AKR1A1", "AKR1B1", "AKT1S1", "ALDH18A1", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALKBH5", "AMOT", "ANAPC1", "ANAPC16", "ANAPC5", "ANKLE2", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEX1", "API5", "APLP2", "APOL2", "APOO", "APP", "APRT", "ARCN1", "ARF4", "ARG2", "ARHGDIA", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARMC6", "ARMT1", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD3A", "ATAD3B", "ATG4B", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATPIF1", "ATXN2L", "B4GAT1", "BABAM1", "BABAM2", "BAIAP2", "BANF1", "BASP1", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCLAF1", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPTF", "BRCA1", "BRI3BP", "BRIX1", "BRMS1L", "BROX", "BSG", "BTF3", "BUB1B", "BUD23", "BYSL", "C12orf43", "C12orf73", "C15orf39", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C5orf15", "CAD", "CALD1", "CALR", "CALU", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBR1", "CBX3", "CCAR1", "CCAR2", "CCDC124", "CCDC47", "CCDC6", "CCDC86", "CCDC97", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD3EAP", "CDC123", "CDC37", "CDC42", "CDC73", "CDCA8", "CDIPT", "CDK5RAP3", "CDK6", "CDKAL1", "CEBPZ", "CECR2", "CENPB", "CENPI", "CEP170", "CERS2", "CFAP20", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHCHD3", "CHERP", "CHMP3", "CHMP7", "CHORDC1", "CHST14", "CIAPIN1", "CIP2A", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLGN", "CLIC1", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT10", "CNOT3", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG7", "COIL", "COLGALT1", "COMMD2", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "CORO1B", "CORO1C", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF2", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRNKL1", "CRTAP", "CS", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDB1", "DDOST", "DDRGK1", "DDX54", "DEK", "DENR", "DERL1", "DFFA", "DGCR8", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7", "DHX29", "DIABLO", "DIAPH1", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DKC1", "DLAT", "DLD", "DLST", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJC10", "DNAJC2", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPH2", "DPM1", "DPP3", "DPYSL2", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1I2", "DYNC1LI1", "DYNLL1", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI2", "ECSIT", "EDC4", "EEF1A2", "EEF1E1", "EEF1G", "EHD1", "EIF2A", "EIF2B1", "EIF2B2", "EIF2B4", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EMG1", "ENO1", "ENSA", "ENY2", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERGIC3", "ERH", "ERLIN2", "ERO1A", "ERP29", "ESD", "ESF1", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC3", "EZR", "F11R", "FADS2", "FAH", "FAM114A2", "FAM120B", "FAM162A", "FAM49B", "FAM8A1", "FAM98A", "FANCI", "FAR1", "FARSA", "FARSB", "FAU", "FBL", "FDFT1", "FDPS", "FECH", "FEN1", "FERMT2", "FH", "FHL1", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GALK1", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GBA", "GCAT", "GCN1", "GDI1", "GDI2", "GEMIN4", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GINS1", "GINS4", "GLA", "GLB1", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GM2A", "GNA13", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLGB1", "GOLIM4", "GORASP2", "GOT1", "GOT2", "GPAA1", "GPD2", "GPI", "GPR107", "GPR108", "GPRASP2", "GPS1", "GRIPAP1", "GRPEL1", "GRSF1", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAUS5", "HAX1", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDHD3", "HDHD5", "HEATR1", "HEBP1", "HECTD1", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIF1AN", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPC", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HOXA10", "HP1BP3", "HPF1", "HPRT1", "HPS6", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTRA2", "HTT", "HYOU1", "IARS", "IARS2", "ICMT", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IGBP1", "IK", "IKBIP", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMPDH2", "INA", "INCENP", "INF2", "INTS14", "INTS3", "IPO4", "IPO5", "IRGQ", "IRS4", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JPT2", "JUP", "KARS", "KDELR1", "KDM1A", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KIAA0368", "KIAA0391", "KIAA2013", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF5B", "KIFBP", "KLC2", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "LAMP1", "LAMTOR1", "LAMTOR2", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDAH", "LDHA", "LDHB", "LEMD3", "LETM1", "LGMN", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LNPEP", "LONP1", "LRPAP1", "LRPPRC", "LRRC47", "LSM12", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L3", "LYAR", "MACF1", "MAGED2", "MAGT1", "MAK16", "MAP1B", "MAP1S", "MAP4", "MAPRE1", "MAPRE2", "MARCKS", "MARCKSL1", "MARS", "MAT2A", "MAU2", "MBD3", "MBOAT7", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED16", "METAP2", "MFN1", "MFN2", "MGEA5", "MGST2", "MGST3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MLEC", "MMAB", "MMGT1", "MMS19", "MOB4", "MOGS", "MORF4L1", "MOV10", "MPHOSPH10", "MPI", "MPST", "MPV17L2", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL53", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTBP", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTR", "MTX1", "MTX2", "MTX3", "MYBBP1A", "MYEF2", "MYG1", "NAA15", "NAA25", "NAA35", "NAA40", "NADK2", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NAT10", "NAXE", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCLN", "NCSTN", "NDC1", "NDRG3", "NDUFA4", "NDUFAF1", "NDUFAF7", "NDUFB11", "NDUFB4", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NELFCD", "NES", "NEU1", "NHP2", "NIP7", "NIPBL", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL11", "NOL6", "NOL7", "NOL9", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NPTN", "NSA2", "NSF", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT21", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUSAP1", "NUTF2", "NXF1", "OAT", "OCIAD1", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL11", "OSBPL6", "OSBPL9", "OTUB1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PBDC1", "PBRM1", "PC", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6IP", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDS5A", "PDS5B", "PEBP1", "PECR", "PES1", "PEX14", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PHAX", "PHB", "PHB2", "PHF5A", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIGS", "PIGT", "PIN4", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PKM", "PLBD2", "PLEC", "PLIN3", "PLRG1", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "POLD1", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PPP6R3", "PPT1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF40A", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSAT1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PTBP1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTRH2", "PTRHD1", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RABGGTA", "RABL6", "RAC1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAD51AP1", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM10", "RBM17", "RBM22", "RBM26", "RBM27", "RBM39", "RBM45", "RBM5", "RBM8A", "RCC2", "RCL1", "RDH11", "RDH13", "RDX", "RECQL", "RECQL5", "REEP5", "REPS1", "RER1", "REXO2", "REXO4", "RFC1", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIF1", "RINT1", "RNASEH2A", "RNASET2", "RNF20", "RNF40", "RNPEP", "ROCK2", "RP2", "RPA1", "RPA3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP15", "RRP1B", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SAE1", "SAFB", "SAFB2", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SARS", "SARS2", "SART1", "SBDS", "SCAF1", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCD", "SCFD1", "SCO1", "SCPEP1", "SCRN1", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A3", "SF3B1", "SFSWAP", "SFXN1", "SGPL1", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A24", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC3A2", "SLC6A15", "SLC9A3R1", "SLFN11", "SLK", "SMARCA4", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMCHD1", "SMPD4", "SMU1", "SMYD3", "SND1", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SNX6", "SNX9", "SOD2", "SON", "SPAG9", 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a/interpro_homologous_superfamily/basic/plot_8.png b/interpro_homologous_superfamily/basic/plot_8.png new file mode 100644 index 0000000000000000000000000000000000000000..e04eb76192365903cadac9fe8eb551d313a45675 --- /dev/null +++ b/interpro_homologous_superfamily/basic/plot_8.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:c136d97d2700c43ab923b3a8f8ae8b3f16824ed92badb5df77a9aeebfada1fa1 +size 149584 diff --git a/interpro_homologous_superfamily/basic/plot_9.png b/interpro_homologous_superfamily/basic/plot_9.png new file mode 100644 index 0000000000000000000000000000000000000000..dd1c5fb2ba682cc2d9851e30fa003e17b87fabbc --- /dev/null +++ b/interpro_homologous_superfamily/basic/plot_9.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:14278d9d3f3ede5f732537ff9972c3206b66a4af059f5e55513cefd21ff097f5 +size 151097 diff --git a/interpro_homologous_superfamily/consensus.joblib b/interpro_homologous_superfamily/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..0525ce1c7cab998662e7e156ffe17b4c203ce8c6 --- /dev/null +++ b/interpro_homologous_superfamily/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:ebcb4cb4e0870f7d0666b632a3c19a95fbcfdf43cc2a184c52b1a529a661658f +size 159622 diff --git a/interpro_homologous_superfamily/df_merge.tsv b/interpro_homologous_superfamily/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..771a8775193cecee0a5e5da53d6ec77ff4d9b9a7 --- /dev/null +++ b/interpro_homologous_superfamily/df_merge.tsv @@ -0,0 +1,7 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Mitochondrial carrier domain superfamily [IPR023395] 11 18 2.7586513649843054 0.0058040418852931 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 1.0 0.0142466262053111 0.0058560324261939 0.002055769463525 1.0422745207145842e-06 +Nucleophile aminohydrolases, N-terminal [IPR029055] 6 18 2.6559824538510592 0.0079077728746754 6.097087378640777 17.820388349514563 1.118176330768516 0.343571999079937 2.960138290874742 0.7151426259133536 1.128434210928413 0.3328142150103464 1.0 0.1135912525516411 0.02421661276018 0.0002808583984775 0.0001279618339571 +Glycoside hydrolase superfamily [IPR017853] 5 14 2.655801188993942 0.0079120244400254 7.094660194174757 15.565533980582524 0.5992585613623983 0.1928722204186086 2.565315823223627 1.245604487832095 1.9386029676344616 0.2695693578719223 1.0 0.1178616319260966 0.2243071172363204 2.8484663686520977e-05 0.0001679272331028 +EF-hand domain pair [IPR011992] 11 42 2.1951933122363965 0.0281497338090916 13.3252427184466 49.37378640776699 0.9065364020670126 0.4404331516970506 4.9772339658485505 4.730718887980642 1.169914018421813 0.3730081256676846 1.0 0.1241751068215353 0.3502235543165021 0.0117044098486948 0.0079400605485958 +Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097] 2 6 2.0476699020294555 0.0405923549015689 2.111650485436894 5.548543689320389 1.4203309343737989 0.1835434124596617 1.027373025804284 0.6683357213562342 0.9844971330203006 0.2264468231852968 1.0 0.0424464003246627 7.149857972393559e-05 0.0010464818333657 0.0005472376514181 +Peptidase M4/M1, CTD superfamily [IPR027268] 2 6 2.0476699020294555 0.0405923549015689 2.111650485436894 5.548543689320389 1.4203309343737989 0.1835434124596617 1.027373025804284 0.6683357213562342 0.9844971330203006 0.2264468231852968 1.0 0.0424464003246627 7.149857972393559e-05 0.0010464818333657 0.0005472376514181 diff --git a/interpro_homologous_superfamily/metrics.json b/interpro_homologous_superfamily/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..d479145896924d03615d58c5d5ca097ce15daa29 --- /dev/null +++ b/interpro_homologous_superfamily/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2454, + "annotations_size": 866, + "title": "Average number of proteins per term", + "value": 4.364896073903003 +} \ No newline at end of file diff --git a/interpro_homologous_superfamily/paths.json b/interpro_homologous_superfamily/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..42e4eaec3511a6c8cfcc94e215157e46b8611ee5 --- /dev/null +++ b/interpro_homologous_superfamily/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_homologous_superfamily/fragment/C340/C340_val_log2fc"} \ No newline at end of file diff --git a/interpro_homologous_superfamily/result.tsv b/interpro_homologous_superfamily/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..a815e8083d346960854ca0c9f7e41312698004eb --- /dev/null +++ b/interpro_homologous_superfamily/result.tsv @@ -0,0 +1,112 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Mitochondrial carrier domain superfamily [IPR023395] 0.7241678660715116 2.7586513649843054 0.0058040418852931 0.9935323560603644 0.0764221334919746 18 Q9Y619,O43772,Q9BSK2,Q9HC21,Q02978,Q6NUK1,O43808,Q9H2D1,P12235,Q9UBX3,Q70HW3 11 +Nucleophile aminohydrolases, N-terminal [IPR029055] 0.7058184926308413 2.6559824538510592 0.0079077728746754 0.9989670656456356 0.0764221334919746 18 P28070,P28072,P20618,P49721,P60900,Q99436 6 +Glycoside hydrolase superfamily [IPR017853] 0.7570551767930472 2.655801188993942 0.0079120244400254 0.99897089197831 0.0764221334919746 14 P06280,P04062,O60502,P16278,P10253 5 +Tubulin/FtsZ, C-terminal [IPR008280] 0.9726530612244896 2.317108644920705 0.0204978142125638 0.9999999837563134 0.1002887407236172 4 Q9BUF5,P07437,P68371 3 +Tubulin/FtsZ, GTPase domain superfamily [IPR036525] 0.9726530612244896 2.317108644920705 0.0204978142125638 0.9999999837563134 0.1002887407236172 4 Q9BUF5,P07437,P68371 3 +Tubulin, C-terminal [IPR023123] 0.9726530612244896 2.317108644920705 0.0204978142125638 0.9999999837563134 0.1002887407236172 4 Q9BUF5,P07437,P68371 3 +Tubulin/FtsZ-like, C-terminal domain [IPR037103] 0.9726530612244896 2.317108644920705 0.0204978142125638 0.9999999837563134 0.1002887407236172 4 Q9BUF5,P07437,P68371 3 +Haem oxygenase-like, multi-helical [IPR016084] 0.991435562805872 2.2395010215982603 0.0251233349237796 0.999999999730587 0.1139099897591263 2 P30519 1 +EF-hand domain pair [IPR011992] 0.5119633185376344 2.1951933122363965 0.0281497338090916 0.9999999999817591 0.1212819377048428 42 P60903,Q02818,Q9Y680,Q9BRK5,P80303,P30626,P60660,Q6NUK1,Q14257,Q9NWM8,O43852 11 +Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097] 0.8487956553260017 2.0476699020294555 0.0405923549015689 0.9999999999999998 0.1535064600207805 6 Q9UIQ6,P55786 2 +Peptidase M4/M1, CTD superfamily [IPR027268] 0.8487956553260017 2.0476699020294555 0.0405923549015689 0.9999999999999998 0.1535064600207805 6 Q9UIQ6,P55786 2 +L27 domain superfamily [IPR036892] 0.9102773246329496 1.901198589597285 0.0572760057708205 1.0 0.1897385764956057 2 Q14168 1 +Porin domain superfamily [IPR023614] 0.8668971632003581 1.9007729842365364 0.0573317541155944 1.0 0.1897385764956057 4 P21796 1 +START-like domain superfamily [IPR023393] 0.8620097046566976 1.8811332259894 0.0599537982372846 1.0 0.194613387398411 4 Q14849 1 +FAD/NAD(P)-binding domain superfamily [IPR036188] 0.5912881862534467 1.8805096525939589 0.0600386521003344 1.0 0.194613387398411 16 Q16134,O95831,Q9UHG3 3 +Metalloenzyme, LuxS/M16 peptidase-like [IPR011249] 0.7370053953010196 1.7846845193587506 0.0743125033406748 1.0 0.2174142834223797 7 O43847,P22695,P31930 3 +Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400] 0.7235262421569126 1.7248398151995277 0.0845563442326717 1.0 0.2295479439043691 7 Q8WUJ1,O43169 2 +Alpha/Beta hydrolase fold [IPR029058] 0.5318878494754753 1.6801979725371323 0.092918803697124 1.0 0.246833386508311 20 Q9HB40,P42785,P50897,P10619,Q9H6V9,P07099,Q9H3G5 7 +Glycosyl hydrolase, all-beta [IPR013780] 0.7814880742744533 1.6769802432431566 0.0935463452801079 1.0 0.2477404740445672 5 P06280,P10253 2 +Chromo-like domain superfamily [IPR016197] 0.7699012942236292 1.6286104488476325 0.1033955108919939 1.0 0.2618143638376221 5 Q13185,P83916 2 +EB1, C-terminal domain superfamily [IPR036133] 0.8417618270799367 1.6098450380566791 0.1074316901858076 1.0 0.268889721678929 2 Q15555 1 +MFS transporter superfamily [IPR036259] 0.7574183324676556 1.576318221053186 0.1149524844780585 1.0 0.2796316054999962 5 Q6NT16 1 +DHS-like NAD/FAD-binding domain superfamily [IPR029035] 0.7443854634544664 1.521538047737703 0.1281248708695459 1.0 0.2982691886371688 5 P49366,Q8IXJ6,P13804,Q13423 4 +FAD-binding, type PCMH-like superfamily [IPR036318] 0.8201468189233188 1.5172299880830096 0.1292086275019155 1.0 0.2991836134135263 2 Q15392 1 +FAD-binding, type PCMH, subdomain 2 [IPR016169] 0.8201468189233188 1.5172299880830096 0.1292086275019155 1.0 0.2991836134135263 2 Q15392 1 +Profilin superfamily [IPR036140] 0.7993474714518656 1.4279710796467522 0.1533001828542315 1.0 0.3294242142723685 2 P07737 1 +Tetratricopeptide-like helical domain superfamily [IPR011990] 0.3699431315915916 1.415699278710037 0.156863569661501 1.0 0.3354169168564442 82 O15460,Q5R3I4,A0AVF1,Q9NSK0,O75718,O75153,Q08752,P13674,Q9NYH9,Q9BQ70,Q92791,Q6DKK2 12 +Nucleotide-binding alpha-beta plait domain superfamily [IPR012677] 0.3453220789023383 1.2870314284957465 0.1980833339834231 1.0 0.3803551379814732 113 Q13242,Q14011,Q9UHX1,Q8WXF1,Q99729,Q92804,Q76FK4,Q16630,Q01844,P09651,Q8IY67,Q9BWF3,P31483,P33240,P98175,Q86V81,Q9NW64,Q9P2N5,P51991,P62995,P84103,Q9Y2U8,P52597,P38159,Q96I25,P31943,Q01085,O60506,P23246,P52756,Q9Y5S9,P55795,Q07955,P31942,Q15233,Q13151,Q14103,O43390,Q15056,P26368,P22626,Q8NFH5,P35637,Q12849,O75494,Q96EP5,O14979,Q96PK6 48 +GOLD domain superfamily [IPR036598] 0.7630505709624799 1.272290703948699 0.2032698502788539 1.0 0.3851896944015043 2 Q9Y3B3 1 +14-3-3 domain superfamily [IPR036815] 0.6347601898743878 1.1426666095990483 0.2531770382339848 1.0 0.434253382513429 6 P61981,P27348,Q04917 3 +6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily [IPR008927] 0.556553417641398 1.1412994171604178 0.2537453446117956 1.0 0.434253382513429 8 Q16836,P40939 2 +PIN-like domain superfamily [IPR029060] 0.67011436444339 1.0922977191327368 0.2747022625646704 1.0 0.4566068318253447 4 Q9UQ84 1 +SH3-like domain superfamily [IPR036028] 0.4484829290134972 1.071558425916879 0.2839184150617093 1.0 0.4665528414486533 18 Q9UQB8,Q14168,Q9NZW5 3 +Metallopeptidase, catalytic domain superfamily [IPR024079] 0.6361865360830202 1.0629621462309216 0.2877991180949597 1.0 0.4697814585356544 5 P42892,Q99797 2 +Translation elongation factor EF1B/ribosomal protein S6 [IPR014717] 0.7096247960848292 1.0451239726075388 0.2959656757463005 1.0 0.4728898066352329 2 P24534 1 +Translation elongation factor eEF-1beta-like superfamily [IPR036219] 0.7096247960848292 1.0451239726075388 0.2959656757463005 1.0 0.4728898066352329 2 P24534 1 +LEM/LEM-like domain superfamily [IPR011015] 0.6238487538961888 1.0108099325686115 0.3121074082845871 1.0 0.4887613301527169 5 Q9Y2U8,Q86XL3 2 +NAD(P)-binding domain superfamily [IPR036291] 0.3419050867938674 0.9787015362622976 0.3277274727957187 1.0 0.5077137592863907 60 Q8N4Q0,Q06136,Q3SXM5,P35270,Q8WWV3,Q8NBX0,Q16836,Q14914 8 +GroES-like superfamily [IPR011032] 0.5121613537613314 0.9693922297939196 0.3323495277084092 1.0 0.5130386648760826 9 Q8N4Q0,Q8WWV3 2 +Zinc finger, RanBP2-type superfamily [IPR036443] 0.5094374431513398 0.9557446505302828 0.3392012581445858 1.0 0.5199084770853297 9 P35637,Q92804 2 +RNA-binding domain superfamily [IPR035979] 0.3208114986390563 0.9266947187199682 0.3540850603774017 1.0 0.5353359855831691 116 Q13242,Q14011,Q9UHX1,Q8WXF1,Q99729,Q92804,Q76FK4,Q16630,Q01844,P09651,Q8IY67,Q9BWF3,P31483,P33240,P98175,Q86V81,Q9NW64,Q9P2N5,P51991,P62995,P84103,Q9Y2U8,P52597,P38159,Q96I25,P31943,Q01085,O60506,P23246,P52756,Q9Y5S9,P55795,Q07955,P31942,Q15233,Q13151,Q14103,O43390,Q15056,P26368,P22626,Q8NFH5,P35637,Q12849,O75494,Q96EP5,O14979,Q96PK6 48 +Vacuolar protein sorting-associated protein 33, domain 3b [IPR043155] 0.6802610114192518 0.9225720063890502 0.3562302895704048 1.0 0.5374484856584854 2 Q96AX1 1 +Galactose-binding-like domain superfamily [IPR008979] 0.501719938860874 0.9171269206804163 0.3590761357108842 1.0 0.5396102162720683 9 P16278 1 +Beta-hexosaminidase-like, domain 2 [IPR029018] 0.7297601758599669 0.916256377413868 0.3595324420196113 1.0 0.5396102162720683 3 P54802 1 +NAD kinase/diacylglycerol kinase-like domain superfamily [IPR016064] 0.6761827079934692 0.9057470999818172 0.3650697264896876 1.0 0.5413971333438935 2 Q4G0N4 1 +Inorganic polyphosphate/ATP-NAD kinase, N-terminal [IPR017438] 0.6761827079934692 0.9057470999818172 0.3650697264896876 1.0 0.5413971333438935 2 Q4G0N4 1 +Prefoldin [IPR009053] 0.6245962828708637 0.9056913889468148 0.3650992215621638 1.0 0.5413971333438935 4 Q99471 1 +HAD-like superfamily [IPR036412] 0.4376042116172965 0.8907349721228063 0.3730713683440809 1.0 0.5503914906064294 15 Q9HD20,Q969T7 2 +HAD superfamily [IPR023214] 0.4376042116172965 0.8907349721228063 0.3730713683440809 1.0 0.5503914906064294 15 Q9HD20,Q969T7 2 +ABC transporter type 1, transmembrane domain superfamily [IPR036640] 0.5640427011505411 0.8392374562165842 0.4013360722994201 1.0 0.5735264663552769 6 P08183 1 +NAP-like superfamily [IPR037231] 0.7037943696450512 0.8195104485487047 0.412495243109745 1.0 0.5836942492369922 3 Q01105,P55209 2 +Annexin superfamily [IPR037104] 0.5712647991307751 0.791453646671129 0.4286793152489159 1.0 0.5939780592088979 5 P20073,P04083,P50995 3 +WW domain superfamily [IPR036020] 0.4826277028945697 0.7812531120709176 0.4346536413487083 1.0 0.5988782797900635 8 Q8WYQ5 1 +G protein alpha subunit, helical insertion [IPR011025] 0.6771062613093392 0.7223634154826346 0.470071073432708 1.0 0.6236536123060507 3 P04899 1 +Calpain large subunit, domain III superfamily [IPR036213] 0.619086460032632 0.6775200537153125 0.4980760508708892 1.0 0.6425356679336196 2 P17655 1 +DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal [IPR008921] 0.5427047025180521 0.6757324727917617 0.4992105148696297 1.0 0.6425356679336196 5 P35251,P35250 2 +Six-bladed beta-propeller, TolB-like [IPR011042] 0.5569309201219717 0.6384956076520498 0.5231511123680996 1.0 0.6628771151334837 4 Q15165 1 +Death-like domain superfamily [IPR011029] 0.6483068135454905 0.6209607671148147 0.534625437143172 1.0 0.6704050771374064 3 Q96FV9,Q12955 2 +Ribonuclease H superfamily [IPR036397] 0.432315210324336 0.6126659330229478 0.5400972525153007 1.0 0.6749267253654407 10 Q9UIV1 1 +Glutathione S-transferase, C-terminal domain superfamily [IPR036282] 0.3788360052209249 0.5357187108786362 0.5921529701171786 1.0 0.7112405993363061 15 Q13505,Q13155,Q9H7Z7,O75431 4 +Aldolase-type TIM barrel [IPR013785] 0.401864154027192 0.5080647447741735 0.6114079386234894 1.0 0.7275690522079272 11 P43490 1 +Ribonuclease H-like superfamily [IPR012337] 0.3923134278045368 0.5077502728410536 0.611628487306433 1.0 0.7275690522079272 12 Q9UIV1,Q96GM8 2 +Longin-like domain superfamily [IPR011012] 0.4030324297639173 0.4715570329985655 0.6372430017152038 1.0 0.7447401342582544 10 P61923,P51809 2 +PDZ superfamily [IPR036034] 0.3620621266009237 0.4169935361554431 0.6766831356555858 1.0 0.7813416016356101 14 Q14168,Q9NZW5,O43464 3 +Thioredoxin-like superfamily [IPR036249] 0.3144443981205949 0.4150306305122351 0.678119480141206 1.0 0.7813416016356101 40 O95881,Q9H7Z7,Q6ZRP7,Q9H2J4,P07237,O75880,Q9H1E5,P78417,Q8IXB1,Q9UJC5,Q96CS3,P30040 12 +Chaperone J-domain superfamily [IPR036869] 0.3604006109650538 0.4078942192512672 0.6833513369557811 1.0 0.7848571058404594 14 Q99543,Q8WXX5,O75937,Q13217,Q8IXB1 5 +Immunoglobulin E-set [IPR014756] 0.3841535290389969 0.3846698049417037 0.7004820691123159 1.0 0.7981808840148232 10 A6NIH7 1 +K homology domain-like, alpha/beta [IPR015946] 0.5330342577487857 0.3762021041437859 0.7067666512476247 1.0 0.8023349659619562 2 P23396 1 +K homology domain superfamily, prokaryotic type [IPR009019] 0.5330342577487857 0.3762021041437859 0.7067666512476247 1.0 0.8023349659619562 2 P23396 1 +RmlC-like cupin domain superfamily [IPR011051] 0.4828571428571376 0.3760131295385515 0.7069071351373817 1.0 0.8023349659619562 4 O00625,P38435,Q9BV57 3 +HSP20-like chaperone [IPR008978] 0.3864499370117791 0.3693238123914568 0.7118863785058704 1.0 0.8049853341377993 9 Q15185,Q9HB71,P04792 3 +Acyl-CoA dehydrogenase-like, C-terminal [IPR036250] 0.4180154910765672 0.3677531167506733 0.7130573302364904 1.0 0.8049853341377993 7 P16219 1 +Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily [IPR037069] 0.4180154910765672 0.3677531167506733 0.7130573302364904 1.0 0.8049853341377993 7 P16219 1 +Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily [IPR009100] 0.4180154910765672 0.3677531167506733 0.7130573302364904 1.0 0.8049853341377993 7 P16219 1 +Homeobox-like domain superfamily [IPR009057] 0.3412029811459435 0.366636744230253 0.7138899960944918 1.0 0.8049853341377993 17 Q96G23 1 +Aldehyde dehydrogenase, N-terminal [IPR016162] 0.3824266676754498 0.3521192955933475 0.7247487981414227 1.0 0.8129954134591607 9 O94788,P51648,P30837 3 +Aldehyde dehydrogenase, C-terminal [IPR016163] 0.3824266676754498 0.3521192955933475 0.7247487981414227 1.0 0.8129954134591607 9 O94788,P51648,P30837 3 +Aldehyde/histidinol dehydrogenase [IPR016161] 0.3824266676754498 0.3521192955933475 0.7247487981414227 1.0 0.8129954134591607 9 O94788,P51648,P30837 3 +Ribosomal protein S10 domain superfamily [IPR036838] 0.5224306688417732 0.3442930217434618 0.7306259317158899 1.0 0.8164155572464008 2 P60866 1 +PITH domain superfamily [IPR037047] 0.5154975530179531 0.3241863244071596 0.7457969750202127 1.0 0.8290888066335098 2 Q9GZP4 1 +Acyl-CoA N-acyltransferase [IPR016181] 0.4266818363700855 0.305623285060108 0.759891489353326 1.0 0.8401961672545532 6 O60502 1 +CRIB domain superfamily [IPR036936] 0.4926590538336183 0.262450587753067 0.792974075683069 1.0 0.8679331448477617 2 O96013 1 +Proteasome activator PA28, C-terminal domain superfamily [IPR036997] 0.5273289556283682 0.2588222087647908 0.7957724214885944 1.0 0.8679331448477617 3 Q9UL46 1 +Proteasome activator superfamily [IPR036252] 0.5273289556283682 0.2588222087647908 0.7957724214885944 1.0 0.8679331448477617 3 Q9UL46 1 +Proteasome activator PA28, N-terminal domain superfamily [IPR036996] 0.5273289556283682 0.2588222087647908 0.7957724214885944 1.0 0.8679331448477617 3 Q9UL46 1 +SNARE [IPR010989] 0.4816476345840199 0.235279865916175 0.8139915212136193 1.0 0.8811458217137429 2 Q86Y82 1 +SH2 domain superfamily [IPR036860] 0.4127032459666241 0.2218356947274076 0.8244417912982387 1.0 0.8902326574367515 5 Q7KZ85 1 +Ubiquitin-conjugating enzyme/RWD-like [IPR016135] 0.3449101018202837 0.218802275892727 0.8268040739257541 1.0 0.8905625970394316 10 Q16763,P49427,Q99816 3 +Sodium/potassium-transporting ATPase subunit beta superfamily [IPR038702] 0.4628874388254634 0.1930734901046376 0.8469014138482109 1.0 0.9084151172900564 2 P54709 1 +50S ribosomal protein L10, insertion domain superfamily [IPR043164] 0.4624796084828763 0.1922142527944003 0.8475743819519233 1.0 0.9084151172900564 2 Q9UKD2 1 +Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal [IPR016098] 0.4592169657422552 0.1854305609697427 0.8528913398614397 1.0 0.9118566670617368 2 O75695 1 +Adenylate cyclase-associated CAP, C-terminal superfamily [IPR036223] 0.4592169657422552 0.1854305609697427 0.8528913398614397 1.0 0.9118566670617368 2 O75695 1 +TFIIS/LEDGF domain superfamily [IPR035441] 0.3981216823193175 0.1828018829300806 0.8549534711435038 1.0 0.9129342860792532 5 P23193,O75475,Q14241,Q7Z4V5 4 +Calreticulin/calnexin, P domain superfamily [IPR009033] 0.4802121583027315 0.1582512317858274 0.8742588351992797 1.0 0.9301082939589388 3 O14967,P27797 2 +Ribosomal protein L10-like domain superfamily [IPR043141] 0.4626682986536047 0.1278564753717123 0.8982625558855957 1.0 0.9509723391160464 3 Q9UKD2,Q7Z7H8 2 +SCP2 sterol-binding domain superfamily [IPR036527] 0.4475724194206439 0.1048161421424636 0.9165217010295909 1.0 0.966757360647534 3 P22307,Q6YN16 2 +UBA-like superfamily [IPR009060] 0.2984277139092893 0.1013327292564963 0.9192863357144796 1.0 0.9684938767989528 14 Q14157,Q9UNZ2,Q96CS3,Q13501 4 +Ribosomal protein S2, flavodoxin-like domain superfamily [IPR023591] 0.3911092985318211 0.0800987456663184 0.9361587203572472 1.0 0.983076489289372 2 P08865 1 +Lamin tail domain superfamily [IPR036415] 0.4283965728274241 0.0796273941586637 0.9365336070019998 1.0 0.983076489289372 3 P20700,Q03252 2 +Signal recognition particle, SRP9/SRP14 subunit [IPR009018] 0.3837683523654225 0.0726634700843293 0.942073918322588 1.0 0.9876949313164178 2 P49458 1 +Moesin tail domain superfamily [IPR008954] 0.4010607915136749 0.0512165369805654 0.9591529745335116 1.0 0.998349129742814 3 P26038,P35241 2 +Endonuclease/exonuclease/phosphatase superfamily [IPR036691] 0.3269387755101985 0.0345088477381227 0.972471387077021 1.0 1.0 4 Q6L8Q7,O95551,Q9ULM6 3 +Sec1-like, domain 3a [IPR043127] 0.3155102040816291 0.0232743885361727 0.981431401166208 1.0 1.0 4 Q8WVM8,Q96AX1,Q9H267 3 +Sec1-like superfamily [IPR036045] 0.3155102040816291 0.0232743885361727 0.981431401166208 1.0 1.0 4 Q8WVM8,Q96AX1,Q9H267 3 +Sec1-like, domain 2 [IPR027482] 0.3155102040816291 0.0232743885361727 0.981431401166208 1.0 1.0 4 Q8WVM8,Q96AX1,Q9H267 3 +Sec1-like, domain 1 [IPR043154] 0.3155102040816291 0.0232743885361727 0.981431401166208 1.0 1.0 4 Q8WVM8,Q96AX1,Q9H267 3 +PWI domain superfamily [IPR036483] 0.3467972256221946 0.0170594099538825 0.986389220360641 1.0 1.0 3 P49756,O43395 2 +Sterile alpha motif/pointed domain superfamily [IPR013761] 0.2991836734693837 0.0100717080758427 0.9919640754853656 1.0 1.0 4 Q15375,Q8IXK0,Q9Y3Z3 3 +Riboflavin synthase-like beta-barrel [IPR017938] 0.3133414932680503 0.0069124818985344 0.9944846813388976 1.0 1.0 3 P16435,Q9UHQ9 2 +Ferredoxin-NADP reductase (FNR), nucleotide-binding domain [IPR039261] 0.3133414932680503 0.0069124818985344 0.9944846813388976 1.0 1.0 3 P16435,Q9UHQ9 2 +Zinc finger, CCCH-type superfamily [IPR036855] 0.2964712138120444 0.003619635953299 0.997111954663552 1.0 1.0 5 Q8IWR0 1 diff --git a/interpro_homologous_superfamily/selections.json b/interpro_homologous_superfamily/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..d5304f064836252d540d70e41d43d401c002accd --- /dev/null +++ b/interpro_homologous_superfamily/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 domain superfamily [IPR036815]", "2Fe-2S ferredoxin-like superfamily [IPR036010]", "30s ribosomal protein S13, C-terminal [IPR027437]", "4'-phosphopantetheinyl transferase domain superfamily [IPR037143]", "5'-3' exonuclease, C-terminal domain superfamily [IPR036279]", "50S ribosomal protein L10, insertion domain superfamily [IPR043164]", "50S ribosomal protein L30e-like [IPR029064]", "6-phosphogluconate dehydrogenase, domain 2 [IPR013328]", "6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily [IPR008927]", "ABC transporter type 1, transmembrane domain superfamily [IPR036640]", "ACP-like superfamily [IPR036736]", "ADF-H/Gelsolin-like domain superfamily [IPR029006]", "ADP-ribosylation/Crystallin J1 superfamily [IPR036705]", "AF1104-like superfamily [IPR036075]", "AH/BAR domain superfamily [IPR027267]", "AICAR transformylase, duplicated domain superfamily [IPR024051]", "AICAR transformylase, insert domain superfamily [IPR024050]", "AMP-binding enzyme, C-terminal domain superfamily [IPR045851]", "ANL, N-terminal domain [IPR042099]", "ANTH domain superfamily [IPR014712]", "AP-2 complex subunit mu, C-terminal superfamily [IPR036168]", "ARFGAP/RecO-like zinc finger [IPR037278]", "ARID DNA-binding domain superfamily [IPR036431]", "ATP synthase subunit alpha, N-terminal domain-like superfamily [IPR023366]", "ATP synthase, F0 complex, subunit D superfamily, mitochondrial [IPR036228]", "ATP synthase, F1 complex, gamma subunit superfamily [IPR035968]", "ATP synthase, alpha subunit, C-terminal domain superfamily [IPR038376]", "ATP-NAD kinase, PpnK-type, C-terminal [IPR017437]", "ATP-grasp fold, subdomain 1 [IPR013815]", "ATP:guanido phosphotransferase, N-terminal domain superfamily [IPR036802]", "ATPase, F1/V1 complex, beta/alpha subunit, C-terminal [IPR024034]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily [IPR036121]", "ATPase, V1 complex, subunit H, C-terminal domain superfamily [IPR038497]", "ATPase, nucleotide binding domain [IPR043129]", "Acetylglutamate kinase-like superfamily [IPR036393]", "Aconitase, domain 2 [IPR015932]", "Aconitase, iron-sulfur domain [IPR036008]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 [IPR015931]", "Aconitase/3-isopropylmalate dehydratase, swivel [IPR015928]", "Actin-crosslinking [IPR008999]", "Actin-related protein 2/3 complex subunit 3 superfamily [IPR036753]", "Activator of Hsp90 ATPase, Aha1 [IPR036338]", "Acyl transferase domain superfamily [IPR001227]", "Acyl transferase/acyl hydrolase/lysophospholipase [IPR016035]", "Acyl-CoA N-acyltransferase [IPR016181]", "Acyl-CoA binding protein superfamily [IPR035984]", "Acyl-CoA dehydrogenase-like, C-terminal [IPR036250]", "Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily [IPR009100]", "Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily [IPR037069]", "Adenine nucleotide alpha hydrolase-like domains [IPR023382]", "Adenosylhomocysteinase-like superfamily [IPR042172]", "Adenylate cyclase-associated CAP, C-terminal superfamily [IPR036223]", "Adenylate cyclase-associated CAP, N-terminal domain superfamily [IPR036222]", "Adenylosuccinate synthetase, domain 1 [IPR042109]", "Adenylosuccinate synthetase, domain 2 [IPR042110]", "Adenylosuccinate synthetase, domain 3 [IPR042111]", "Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily [IPR018162]", "Aldehyde dehydrogenase, C-terminal [IPR016163]", "Aldehyde dehydrogenase, N-terminal [IPR016162]", "Aldehyde/histidinol dehydrogenase [IPR016161]", "Aldolase-type TIM barrel [IPR013785]", "Alkaline-phosphatase-like, core domain superfamily [IPR017850]", "Allosteric substrate binding domain superfamily [IPR029009]", "Alpha-D-phosphohexomutase, C-terminal domain superfamily [IPR036900]", "Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III [IPR016055]", "Alpha-catenin/vinculin-like superfamily [IPR036723]", "Alpha-glycerophosphate oxidase, C-terminal domain superfamily [IPR038299]", "Alpha-helical ferredoxin [IPR009051]", "Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily [IPR036784]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily [IPR037151]", "Alpha/Beta hydrolase fold [IPR029058]", "Alpha/beta knot methyltransferases [IPR029028]", "Amidase signature (AS) superfamily [IPR036928]", "Aminoacyl-tRNA synthetase, class Ia, anticodon-binding [IPR009080]", "Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097]", "Aminotransferase-like, PLP-dependent enzymes [IPR036038]", "Amyloidogenic glycoprotein, amyloid-beta peptide superfamily [IPR037071]", "Amyloidogenic glycoprotein, copper-binding domain superfamily [IPR036669]", "Amyloidogenic glycoprotein, heparin-binding domain superfamily [IPR036454]", "Ankyrin repeat-containing domain superfamily [IPR036770]", "Annexin superfamily [IPR037104]", "Anticodon-binding domain superfamily [IPR036621]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain superfamily [IPR036732]", "ApaG domain superfamily [IPR036767]", "ArfGAP domain superfamily [IPR038508]", "Arginyl tRNA synthetase N-terminal domain superfamily [IPR036695]", "Armadillo-like helical [IPR011989]", "Armadillo-type fold [IPR016024]", "Arp2/3 complex subunit 2/4 [IPR034666]", "Arrestin-like, C-terminal [IPR014752]", "Aspartate decarboxylase-like domain superfamily [IPR009010]", "Aspartate/ornithine carbamoyltransferase superfamily [IPR036901]", "Aspartic peptidase domain superfamily [IPR021109]", "Aspartyl/glutamyl-tRNA amidotransferase subunit B-like [IPR003789]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C-terminal, domain 2 [IPR023168]", "At2g17340, three-helix bundle domain [IPR035073]", "B30.2/SPRY domain superfamily [IPR043136]", "BEACH domain superfamily [IPR036372]", "BRCT domain superfamily [IPR036420]", "BRK domain superfamily [IPR037259]", "BRO1 domain superfamily [IPR038499]", "BSD domain superfamily [IPR035925]", "Bacterial exopeptidase dimerisation domain [IPR036264]", "Band 7/SPFH domain superfamily [IPR036013]", "Barrier-to-autointegration factor, BAF superfamily [IPR036617]", "Bcl-2-like superfamily [IPR036834]", "Beta-Galactosidase/glucuronidase domain superfamily [IPR036156]", "Beta-grasp domain superfamily [IPR012675]", "Beta-hexosaminidase-like, domain 2 [IPR029018]", "Beta-lactamase/transpeptidase-like [IPR012338]", "BolA-like superfamily [IPR036065]", "Branched-chain-amino-acid aminotransferase-like, C-terminal [IPR043132]", "Branched-chain-amino-acid aminotransferase-like, N-terminal [IPR043131]", "Bromo adjacent homology (BAH) domain superfamily [IPR043151]", "Bromodomain-like superfamily [IPR036427]", "C2 domain superfamily [IPR035892]", "CAP Gly-rich domain superfamily [IPR036859]", "CCR4-NOT complex subunit 2/3/5, N-terminal domain superfamily [IPR038635]", "CCR4-NOT subunit 1, TTP binding domain superfamily [IPR038535]", "CDC48 domain 2-like superfamily [IPR029067]", "CDP-alcohol phosphatidyltransferase, transmembrane domain [IPR043130]", "CENP-B, dimerisation domain superfamily [IPR034882]", "CH domain superfamily [IPR036872]", "CRIB domain superfamily [IPR036936]", "CSTF1, dimerization domain superfamily [IPR038184]", "Cadherin-like superfamily [IPR015919]", "Calcyclin-binding protein, N-terminal [IPR037201]", "Calpain large subunit, domain III superfamily [IPR036213]", "Calreticulin/calnexin, P domain superfamily [IPR009033]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily [IPR036480]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily [IPR036897]", "Carbohydrate-binding-like fold [IPR013784]", "Carboxypeptidase-like, regulatory domain superfamily [IPR008969]", "Carnitine o-acyltransferase, N-terminal [IPR042572]", "Casein kinase II subunit beta-like [IPR035991]", "Casein kinase II, regulatory subunit, N-terminal [IPR016149]", "Catenin binding domain superfamily [IPR027397]", "Cdc37, Hsp90-binding domain superfamily [IPR038189]", "Cell division control protein 73, C-terminal domain superfamily [IPR038103]", "Chaperone J-domain superfamily [IPR036869]", "Chitinase insertion domain superfamily [IPR029070]", "Chloramphenicol acetyltransferase-like domain superfamily [IPR023213]", "Chloride channel, core [IPR014743]", "Choline/Carnitine o-acyltransferase, domain 2 [IPR042231]", "Chromo-like domain superfamily [IPR016197]", "Citrate synthase superfamily [IPR036969]", "Citrate synthase-like, large alpha subdomain [IPR016142]", "Citrate synthase-like, small alpha subdomain [IPR016143]", "Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm [IPR010978]", "Class I glutamine amidotransferase-like [IPR029062]", "Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) [IPR045864]", "Class II aldolase/adducin N-terminal domain superfamily [IPR036409]", "Clathrin adaptor, appendage, Ig-like subdomain superfamily [IPR013041]", "Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain [IPR013037]", "Clathrin heavy chain, N-terminal [IPR016025]", "ClpP/crotonase-like domain superfamily [IPR029045]", "Coatomer, gamma subunit, appendage domain superfamily [IPR037067]", "Coatomer/calthrin adaptor appendage, C-terminal subdomain [IPR009028]", "Cobalamin adenosyltransferase-like superfamily [IPR036451]", "Cobalamin-binding domain superfamily [IPR036724]", "Concanavalin A-like lectin/glucanase domain superfamily [IPR013320]", "Creatinase/Aminopeptidase P/Spt16, N-terminal [IPR029149]", "Creatinase/aminopeptidase-like [IPR036005]", "Cullin homology domain superfamily [IPR036317]", "Cullin repeat-like-containing domain superfamily [IPR016159]", "Cupredoxin [IPR008972]", "Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal [IPR016098]", "Cyclic nucleotide-binding-like [IPR018490]", "Cyclic phosphodiesterase [IPR009097]", "Cyclophilin-like domain superfamily [IPR029000]", "Cytidine deaminase-like [IPR016193]", "Cytochrome C oxidase subunit II, transmembrane domain superfamily [IPR036257]", "Cytochrome P450 superfamily [IPR036396]", "Cytochrome b-c1 complex subunit 8 superfamily [IPR036642]", "Cytochrome b-c1 complex subunit 9 superfamily [IPR036656]", "Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400]", "Cytochrome c oxidase subunit IV superfamily [IPR036639]", "Cytochrome c oxidase subunit VIIc superfamily [IPR036636]", "Cytochrome c oxidase, subunit VIIa superfamily [IPR036539]", "Cytochrome c oxidase, subunit Va/VI superfamily [IPR036545]", "Cytochrome c oxidase, subunit Vb superfamily [IPR036972]", "Cytochrome c-like domain superfamily [IPR036909]", "Cytochrome c1, transmembrane anchor, C-terminal [IPR021157]", "Cytochrome cd1-nitrite reductase-like, haem d1 domain superfamily [IPR011048]", "DHS-like NAD/FAD-binding domain superfamily [IPR029035]", "DNA breaking-rejoining enzyme, catalytic core [IPR011010]", "DNA fragmentation factor 45kDa, C-terminal [IPR027296]", "DNA ligase, ATP-dependent, N-terminal domain superfamily [IPR036599]", "DNA mismatch repair protein MutS, N-terminal [IPR016151]", "DNA mismatch repair protein MutS, core domain superfamily [IPR036187]", "DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal [IPR008921]", "DNA polymerase family B, thumb domain [IPR042087]", "DNA polymerase, palm domain superfamily [IPR023211]", "DNA topoisomerase I, DNA binding, N-terminal domain 1 [IPR013034]", "DNA topoisomerase I, DNA binding, N-terminal domain 2 [IPR013030]", "DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily [IPR036202]", "DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type [IPR014711]", "DNA topoisomerase I, catalytic core, alpha/beta subdomain [IPR014727]", "DNA topoisomerase, type IIA, alpha-helical domain superfamily [IPR013757]", "DNA topoisomerase, type IIA, domain A, alpha-beta [IPR013758]", "DNA topoisomerase, type IIA, subunit B, C-terminal [IPR013759]", "DNA topoisomerase, type IIA-like domain superfamily [IPR013760]", "DNA-binding domain superfamily [IPR016177]", "DNA-directed RNA polymerase, N-terminal domain superfamily [IPR037159]", "DNA-directed RNA polymerase, insert domain superfamily [IPR036643]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily [IPR037033]", "DNA/RNA polymerase superfamily [IPR043502]", "DUSP-like superfamily [IPR035927]", "Dbl homology (DH) domain superfamily [IPR035899]", "Death-like domain superfamily [IPR011029]", "Dedicator of cytokinesis, C-terminal, lobe A [IPR043161]", "Dedicator of cytokinesis, C-terminal, lobe C [IPR043162]", "Deoxyhypusine synthase superfamily [IPR036982]", "Diaphanous, GTPase-binding domain superfamily [IPR044933]", "Dihydrofolate reductase-like domain superfamily [IPR024072]", "Dihydropteroate synthase-like [IPR011005]", "Diphthamide synthesis DPH1/DPH2, domain 1 [IPR042263]", "Diphthamide synthesis DPH1/DPH2, domain 3 [IPR042265]", "Disintegrin domain superfamily [IPR036436]", "Dynein heavy chain AAA lid domain superfamily [IPR042219]", "Dynein heavy chain, AAA1 domain, small subdomain [IPR043157]", "Dynein heavy chain, C-terminal domain, barrel region [IPR043160]", "Dynein heavy chain, domain 2, N-terminal [IPR042222]", "Dynein heavy chain, linker, subdomain 3 [IPR042228]", "Dynein light chain superfamily [IPR037177]", "E2 domain superfamily [IPR036176]", "E3-binding domain superfamily [IPR036625]", "EB1, C-terminal domain superfamily [IPR036133]", "EF-G domain III/V-like [IPR035647]", "EF-hand domain pair [IPR011992]", "ENTH/VHS [IPR008942]", "ERO1-like superfamily [IPR037192]", "ERV/ALR sulfhydryl oxidase domain superfamily [IPR036774]", "ESCRT assembly domain [IPR037202]", "EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2 [IPR042044]", "Elongation factor EF1B gamma, C-terminal domain superfamily [IPR036433]", "Elongation factor Ts, dimerisation domain superfamily [IPR036402]", "Endonuclease/exonuclease/phosphatase superfamily [IPR036691]", "Endoplasmic reticulum resident protein 29, C-terminal domain superfamily [IPR036356]", "Enhancer of mRNA-decapping protein 4, conserved C-terminal domain [IPR044938]", "Enhancer of rudimentary superfamily [IPR035912]", "Enolase-like, C-terminal domain superfamily [IPR036849]", "Enolase-like, N-terminal [IPR029017]", "Enoyl-CoA hydratase, C-terminal [IPR014748]", "Eukaryotic translation initiation factor 3-like domain superfamily [IPR023194]", "Exocyst complex component EXOC3/Sec6, C-terminal domain [IPR042532]", "Exoribonuclease, PH domain 2 superfamily [IPR036345]", "F-actin capping protein, alpha subunit, domain 1 [IPR042489]", "F-actin-capping protein subunit alpha/beta [IPR037282]", "F-actin-capping protein subunit alpha/beta, domain 2 [IPR042276]", "F-actin-capping protein subunit beta, N-terminal domain [IPR043175]", "F-box-like domain superfamily [IPR036047]", "F1F0 ATP synthase OSCP/delta subunit, N-terminal domain superfamily [IPR026015]", "FAD-binding, type PCMH, subdomain 1 [IPR016167]", "FAD-binding, type PCMH, subdomain 2 [IPR016169]", "FAD-binding, type PCMH-like superfamily [IPR036318]", "FAD-linked oxidase-like, C-terminal [IPR016164]", "FAD/NAD(P)-binding domain superfamily [IPR036188]", "FAD/NAD-linked reductase, dimerisation domain superfamily [IPR016156]", "FCS-type zinc finger superfamily [IPR038603]", "FERM superfamily, second domain [IPR035963]", "FERM/acyl-CoA-binding protein superfamily [IPR014352]", "FF domain superfamily [IPR036517]", "FIP-RBD, C-terminal domain superfamily [IPR037245]", "FKBP12-rapamycin binding domain superfamily [IPR036738]", "FTO, C-terminal domain superfamily [IPR038413]", "Ferredoxin-NADP reductase (FNR), nucleotide-binding domain [IPR039261]", "Ferritin-like superfamily [IPR009078]", "Fibronectin type II domain superfamily [IPR036943]", "Fibronectin type III superfamily [IPR036116]", "Flavoprotein-like superfamily [IPR029039]", "Formin, FH2 domain superfamily [IPR042201]", "Formyl transferase, N-terminal domain superfamily [IPR036477]", "Fumarase/histidase, N-terminal [IPR024083]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily [IPR037099]", "Fumarylacetoacetase, N-terminal domain superfamily [IPR036462]", "Fumarylacetoacetase-like, C-terminal domain superfamily [IPR036663]", "G protein alpha subunit, helical insertion [IPR011025]", "GAD-like domain superfamily [IPR004115]", "GAR domain superfamily [IPR036534]", "GAT domain superfamily [IPR038425]", "GHMP kinase, C-terminal domain superfamily [IPR036554]", "GINS, helical bundle-like domain superfamily [IPR036224]", "GLE1-like superfamily [IPR038506]", "GM2-AP, lipid-recognition domain superfamily [IPR036846]", "GMP phosphodiesterase, delta subunit superfamily [IPR037036]", "GOLD domain superfamily [IPR036598]", "GSKIP domain superfamily [IPR023231]", "GTF2I-like repeat superfamily [IPR036647]", "GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 [IPR027266]", "GTP-binding protein, orthogonal bundle domain superfamily [IPR023179]", "GTP1/OBG domain superfamily [IPR036726]", "GYF-like domain superfamily [IPR035445]", "Galactose mutarotase-like domain superfamily [IPR011013]", "Galactose oxidase/kelch, beta-propeller [IPR011043]", "Galactose-binding-like domain superfamily [IPR008979]", "Gamma-glutamyl cyclotransferase-like superfamily [IPR036568]", "Gamma-tubulin complex component, C-terminal domain superfamily [IPR042241]", "Gelsolin-like domain superfamily [IPR036180]", "Glutamine synthetase/guanido kinase, catalytic domain [IPR014746]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1 [IPR042558]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2 [IPR042559]", "Glutathione S-transferase, C-terminal domain superfamily [IPR036282]", "Glutathione synthase, C-terminal, eukaryotic [IPR014709]", "Glutathione synthase, N-terminal, eukaryotic [IPR014049]", "Glutathione synthase, alpha-helical [IPR014042]", "Glutathione synthase, substrate-binding domain superfamily [IPR037013]", "Glycine cleavage T-protein/YgfZ, C-terminal [IPR029043]", "Glycoside hydrolase superfamily [IPR017853]", "Glycosyl hydrolase family 63, N-terminal domain superfamily [IPR038518]", "Glycosyl hydrolase, all-beta [IPR013780]", "Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [IPR029068]", "GroEL-like apical domain superfamily [IPR027409]", "GroEL-like equatorial domain superfamily [IPR027413]", "GroES chaperonin superfamily [IPR037124]", "GroES-like superfamily [IPR011032]", "Growth arrest and DNA damage-inducible proteins-interacting protein 1 domain superfamily [IPR043035]", "Growth factor receptor cysteine-rich domain superfamily [IPR009030]", "GrpE nucleotide exchange factor, coiled-coil [IPR013805]", "GrpE nucleotide exchange factor, head [IPR009012]", "Guanylate-binding protein, C-terminal domain superfamily [IPR036543]", "H/ACA RNP complex subunit Gar1/Naf1, Cbf5-binding domain [IPR038664]", "HAD superfamily [IPR023214]", "HAD-like superfamily [IPR036412]", "HAD-superfamily hydrolase, subfamily IA, REG-2-like, capping domain superfamily [IPR044924]", "HBS1-like protein, N-terminal domain superfamily [IPR037189]", "HECT, E3 ligase catalytic domain [IPR035983]", "HIT-like superfamily [IPR036265]", "HIV integrase-binding domain superfamily [IPR036218]", "HR1 repeat superfamily [IPR036274]", "HRDC domain superfamily [IPR044876]", "HRDC-like superfamily [IPR010997]", "HSP20-like chaperone [IPR008978]", "HSP40/DnaJ peptide-binding [IPR008971]", "HSP90, C-terminal domain [IPR037196]", "Haem oxygenase-like, multi-helical [IPR016084]", "Heat shock protein 70kD, C-terminal domain superfamily [IPR029048]", "Heat shock protein 70kD, peptide-binding domain superfamily [IPR029047]", "Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410]", "Hemimethylated DNA-binding domain superfamily [IPR036623]", "High mobility group box domain superfamily [IPR036910]", "Histidine kinase/HSP90-like ATPase superfamily [IPR036890]", "Histidine phosphatase superfamily [IPR029033]", "Histone acetyl transferase 1, N-terminal domain superfamily [IPR037113]", "Histone acetyltransferase HAT1, C-terminal [IPR013523]", "Histone deacetylase domain superfamily [IPR037138]", "Histone-fold [IPR009072]", "Homeobox-like domain superfamily [IPR009057]", "Homocysteine-binding domain superfamily [IPR036589]", "HotDog domain superfamily [IPR029069]", "Hypoxia-inducible factor 1-alpha inhibitor, domain II [IPR027452]", "I/LWEQ domain superfamily [IPR035964]", "ISWI, HAND domain superfamily [IPR036306]", "Immunoglobulin E-set [IPR014756]", "Immunoglobulin-like domain superfamily [IPR036179]", "Immunoglobulin-like fold [IPR013783]", "Importin-alpha, importin-beta-binding domain superfamily [IPR036975]", "Initiation factor 2B-like, C-terminal [IPR042529]", "Inorganic polyphosphate/ATP-NAD kinase, N-terminal [IPR017438]", "Inorganic pyrophosphatase superfamily [IPR036649]", "Inosine triphosphate pyrophosphatase-like [IPR029001]", "Integrase-like, N-terminal [IPR017856]", "Integrin beta tail domain superfamily [IPR036349]", "Integrin domain superfamily [IPR032695]", "Invasin/intimin cell-adhesion fragments [IPR008964]", "Isochorismatase-like superfamily [IPR036380]", "Isopenicillin N synthase-like superfamily [IPR027443]", "Isoprenoid synthase domain superfamily [IPR008949]", "K Homology domain, type 1 superfamily [IPR036612]", "K homology domain superfamily, prokaryotic type [IPR009019]", "K homology domain-like, alpha/beta [IPR015946]", "KA1 domain/Ssp2, C-terminal [IPR028375]", "Kelch-type beta propeller [IPR015915]", "Kinesin motor domain superfamily [IPR036961]", "Kinesin-like protein Kif23, Arf6-interacting domain superfamily [IPR038105]", "Kringle-like fold [IPR013806]", "Ku, C-terminal domain superfamily [IPR036494]", "Ku70, bridge and pillars domain superfamily [IPR027388]", "L-Aspartase-like [IPR008948]", "L21-like superfamily [IPR036164]", "L27 domain superfamily [IPR036892]", "L28p-like [IPR034704]", "LAP1C-like, C-terminal domain superfamily [IPR038599]", "LDL receptor-like superfamily [IPR036055]", "LEM/LEM-like domain superfamily [IPR011015]", "LIS1, N-terminal [IPR037190]", "LSM domain superfamily [IPR010920]", "Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal [IPR015955]", "Lamin tail domain superfamily [IPR036415]", "Leucine-rich repeat domain superfamily [IPR032675]", "LexA/Signal peptidase-like superfamily [IPR036286]", "Longin-like domain superfamily [IPR011012]", "MAGE homology domain, winged helix WH1 motif [IPR041898]", "MAGE homology domain, winged helix WH2 motif [IPR041899]", "MAN1, winged-helix domain [IPR041885]", "MFS transporter superfamily [IPR036259]", "MHC class I-like antigen recognition-like superfamily [IPR037055]", "MHC classes I/II-like antigen recognition protein [IPR011162]", "MIT domain superfamily [IPR036181]", "MOB kinase activator superfamily [IPR036703]", "MRG, C-terminal domain superfamily [IPR038217]", "MRP-L47 superfamily, mitochondrial [IPR038340]", "Macro domain-like [IPR043472]", "Malic enzyme, N-terminal domain superfamily [IPR037062]", "Malonyl-CoA ACP transacylase, ACP-binding [IPR016036]", "Manganese/iron superoxide dismutase, C-terminal domain superfamily [IPR036314]", "Manganese/iron superoxide dismutase, N-terminal domain superfamily [IPR036324]", "Mannose-6-phosphate receptor binding domain superfamily [IPR009011]", "Membrane associated eicosanoid/glutathione metabolism-like domain superfamily [IPR023352]", "Metal-dependent hydrolase [IPR032466]", "Metal-dependent hydrolase, composite domain superfamily [IPR011059]", "Metallo-dependent phosphatase-like [IPR029052]", "Metalloenzyme, LuxS/M16 peptidase-like [IPR011249]", "Metallopeptidase, catalytic domain superfamily [IPR024079]", "Methionine synthase domain [IPR036594]", "Methionyl-tRNA synthetase, Zn-domain [IPR029038]", "Methylglyoxal synthase-like domain superfamily [IPR036914]", "Methylthioribose-1-phosphate isomerase, N-terminal [IPR027363]", "Methylthiotransferase, N-terminal domain superfamily [IPR038135]", "Mib/herc2 domain superfamily [IPR037252]", "MitoNEET, CDGSH iron-sulfur domain [IPR042216]", "Mitochondrial carrier domain superfamily [IPR023395]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamily [IPR037169]", "Mitochondrial glycoprotein superfamily [IPR036561]", "Mitochondrial outer membrane translocase complex, Tom20 domain superfamily [IPR023392]", "MoaB/Mog-like domain superfamily [IPR036425]", "Moesin tail domain superfamily [IPR008954]", "Mre11, capping domain [IPR038487]", "Mss4-like superfamily [IPR011057]", "Mss4/translationally controlled tumour-associated TCTP [IPR011323]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily [IPR042179]", "MutS, connector domain superfamily [IPR036678]", "Myosin S1 fragment, N-terminal [IPR008989]", "NAC A/B domain superfamily [IPR038187]", "NAD kinase/diacylglycerol kinase-like domain superfamily [IPR016064]", "NAD(P)-binding domain superfamily [IPR036291]", "NADH-quinone oxidoreductase subunit E, N-terminal [IPR041921]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily [IPR037225]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily [IPR037207]", "NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily [IPR037232]", "NADP-dependent oxidoreductase domain superfamily [IPR036812]", "NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily [IPR023173]", "NAP-like superfamily [IPR037231]", "NET domain superfamily [IPR038336]", "NO signalling/Golgi transport ligand-binding domain superfamily [IPR024096]", "NOB1 zinc finger-like superfamily [IPR036283]", "NSFL1 cofactor p47, SEP domain superfamily [IPR036241]", "NTF2-like domain superfamily [IPR032710]", "NUDIX hydrolase-like domain superfamily [IPR015797]", "NVL2, N-terminal domain superfamily [IPR038100]", "NagB/RpiA transferase-like [IPR037171]", "Neurolysin/Thimet oligopeptidase, N-terminal [IPR024080]", "Neurolysin/Thimet oligopeptidase, domain 2 [IPR024077]", "Nicotinate phosphoribosyltransferase-like, C-terminal [IPR036068]", "Nitrogen regulatory PII-like, alpha/beta [IPR011322]", "Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal [IPR015867]", "Nitrous oxide reductase, N-terminal [IPR011045]", "Nop domain superfamily [IPR036070]", "Nop, C-terminal domain [IPR042239]", "Nucleic acid-binding, OB-fold [IPR012340]", "Nucleophile aminohydrolases, N-terminal [IPR029055]", "Nucleoplasmin core domain superfamily [IPR036824]", "Nucleoporin, Nup155-like, C-terminal, subdomain 1 [IPR042533]", "Nucleoporin, Nup155-like, C-terminal, subdomain 2 [IPR042537]", "Nucleoporin, Nup155-like, C-terminal, subdomain 3 [IPR042538]", "Nucleoside diphosphate kinase-like domain superfamily [IPR036850]", "Nucleoside phosphorylase superfamily [IPR035994]", "Nucleotide-binding alpha-beta plait domain superfamily [IPR012677]", "Nucleotide-diphospho-sugar transferases [IPR029044]", "Nucleotidyltransferase superfamily [IPR043519]", "Nucleotidyltransferase, class I-like, C-terminal [IPR011068]", "NusG, N-terminal domain superfamily [IPR036735]", "Oxygen-dependent coproporphyrinogen III oxidase superfamily [IPR036406]", "Oxysterol-binding protein superfamily [IPR037239]", "P-loop containing nucleoside triphosphate hydrolase [IPR027417]", "P-type ATPase, A domain superfamily [IPR008250]", "P-type ATPase, cytoplasmic domain N [IPR023299]", "P-type ATPase, transmembrane domain superfamily [IPR023298]", "P-type trefoil domain superfamily [IPR044913]", "PABC (PABP) domain [IPR036053]", "PADR1 domain superfamily [IPR038650]", "PBDC1-like domain superfamily [IPR023139]", "PDCD5-like superfamily [IPR036883]", "PDZ superfamily [IPR036034]", "PEBP-like superfamily [IPR036610]", "PFU domain superfamily [IPR038122]", "PH-like domain superfamily [IPR011993]", "PIN-like domain superfamily [IPR029060]", "PITH domain superfamily [IPR037047]", "PNPase/RNase PH domain superfamily [IPR027408]", "POLO box domain superfamily [IPR036947]", "PPM-type phosphatase domain superfamily [IPR036457]", "PRP4-like superfamily [IPR036285]", "PTPA superfamily [IPR037218]", "PUA domain superfamily [IPR036974]", "PUA-like superfamily [IPR015947]", "PWI domain superfamily [IPR036483]", "PX domain superfamily [IPR036871]", "Paired amphipathic helix superfamily [IPR036600]", "Pancreatic trypsin inhibitor Kunitz domain superfamily [IPR036880]", "PapD-like superfamily [IPR008962]", "Papain-like cysteine peptidase superfamily [IPR038765]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily [IPR036959]", "Peptidase C65, otubain, subdomain 2 [IPR042467]", "Peptidase C65, otubain, subdomain 1 [IPR042468]", "Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily [IPR038502]", "Peptidase M13, domain 2 [IPR042089]", "Peptidase M4/M1, CTD superfamily [IPR027268]", "Peptidase M41-like [IPR037219]", "Peptidase M60, enhancin-like domain 3 [IPR042279]", "Peptidase S1, PA clan [IPR009003]", "Peptidase S59, nucleoporin superfamily [IPR036903]", "Peptidase S8/S53 domain superfamily [IPR036852]", "Peptidyl-tRNA hydrolase II domain superfamily [IPR023476]", "Phenylalanyl-tRNA synthetase-like, B3/B4 [IPR020825]", "Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily [IPR036940]", "Phosphofructokinase superfamily [IPR035966]", "Phosphoglucose isomerase, C-terminal [IPR023096]", "Phosphoglycerate kinase superfamily [IPR036043]", "Phosphoglycerate kinase, N-terminal [IPR015824]", "Phospholipase B-like, domain 1 [IPR043040]", "Phospholipase B-like, domain 2 [IPR043041]", "Phospholipase B-like, domain 3 [IPR043042]", "Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily [IPR036604]", "Phosphoribosylglycinamide synthetase, C-domain superfamily [IPR037123]", "Phosphoribosyltransferase-like [IPR029057]", "Phosphorylated adapter RNA export protein, RNA-binding domain superfamily [IPR038092]", "Phosphotyrosine protein phosphatase I superfamily [IPR036196]", "Phosphotyrosyl phosphatase activator, C-terminal lid domain [IPR043170]", "Plakin repeat superfamily [IPR035915]", "Poly(ADP-ribose) polymerase, regulatory domain superfamily [IPR036616]", "Polyketide synthase, dehydratase domain superfamily [IPR042104]", "Polymerase/histidinol phosphatase-like [IPR016195]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily [IPR036456]", "Porin domain superfamily [IPR023614]", "Pre-ATP-grasp domain superfamily [IPR016185]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily [IPR042516]", "Prefoldin [IPR009053]", "Profilin superfamily [IPR036140]", "Prolyl-tRNA synthetase, class II [IPR017449]", "Proteasomal ubiquitin receptor Rpn13/ADRM1, Pru domain superfamily [IPR038633]", "Proteasome activator PA28, C-terminal domain superfamily [IPR036997]", "Proteasome activator PA28, N-terminal domain superfamily [IPR036996]", "Proteasome activator superfamily [IPR036252]", "Proteasome assembly chaperone 2 superfamily [IPR038389]", "Protein arginine methyltransferase NDUFAF7 superfamily [IPR038375]", "Protein kinase-like domain superfamily [IPR011009]", "Protein-tyrosine phosphatase-like [IPR029021]", "Prp8 RNase domain IV, fingers region [IPR043173]", "Prp8 RNase domain IV, palm region [IPR043172]", "Pseudouridine synthase I, TruA, C-terminal [IPR020095]", "Pseudouridine synthase TruA/RsuA/RluB/E/F, N-terminal [IPR020094]", "Pseudouridine synthase, TruD, catalytic domain [IPR042214]", "Pseudouridine synthase, catalytic domain superfamily [IPR020103]", "PurM-like, C-terminal domain superfamily [IPR036676]", "PurM-like, N-terminal domain superfamily [IPR036921]", "Putative DNA-binding domain superfamily [IPR009061]", "Pyridoxal phosphate-dependent transferase [IPR015424]", "Pyridoxal phosphate-dependent transferase, major domain [IPR015421]", "Pyridoxal phosphate-dependent transferase, small domain [IPR015422]", "Pyruvate kinase, C-terminal domain superfamily [IPR036918]", "Pyruvate kinase, insert domain superfamily [IPR015806]", "Pyruvate kinase-like domain superfamily [IPR040442]", "Pyruvate kinase-like, insert domain superfamily [IPR011037]", "Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily [IPR015813]", "Quinoprotein alcohol dehydrogenase-like superfamily [IPR011047]", "Quinoprotein amine dehydrogenase, beta chain-like [IPR011044]", "R3H domain superfamily [IPR036867]", "RAP domain superfamily [IPR036744]", "RGS domain superfamily [IPR036305]", "RNA 3'-terminal phosphate cyclase domain superfamily [IPR037136]", "RNA 3'-terminal phosphate cyclase, insert domain superfamily [IPR036553]", "RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta [IPR013792]", "RNA polymerase Rpb1, clamp domain superfamily [IPR044893]", "RNA polymerase Rpb1, domain 3 superfamily [IPR042102]", "RNA polymerase Rpb1, domain 7 superfamily [IPR038593]", "RNA polymerase Rpb1, funnel domain superfamily [IPR038120]", "RNA polymerase Rpb2, OB-fold [IPR014724]", "RNA polymerase Rpb2, domain 2 superfamily [IPR037034]", "RNA polymerase Rpb5, N-terminal domain superfamily [IPR036710]", "RNA polymerase Rpb7-like, N-terminal domain superfamily [IPR036898]", "RNA polymerase, RBP11-like subunit [IPR036603]", "RNA-binding S4 domain superfamily [IPR036986]", "RNA-binding domain superfamily [IPR035979]", "RPB5-like RNA polymerase subunit superfamily [IPR035913]", "RPN13, DEUBAD domain superfamily [IPR038108]", "RRF superfamily [IPR036191]", "RUN domain superfamily [IPR037213]", "Rab geranylgeranyltransferase, alpha subunit, insert-domain superfamily [IPR036254]", "Rab-GTPase-TBC domain superfamily [IPR035969]", "Radical SAM, alpha/beta horseshoe [IPR023404]", "Ran-GTPase activating protein 1, C-terminal domain superfamily [IPR036720]", "Rap/Ran-GAP superfamily [IPR035974]", "Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II [IPR009091]", "Regulatory factor, effector binding domain superfamily [IPR011256]", "Rho GDP-dissociation inhibitor domain superfamily [IPR024792]", "Rho GTPase activation protein [IPR008936]", "Rhodanese-like domain superfamily [IPR036873]", "Rhomboid-like superfamily [IPR035952]", "Riboflavin synthase-like beta-barrel [IPR017938]", "Ribokinase-like [IPR029056]", "Ribonuclease H superfamily [IPR036397]", "Ribonuclease H-like superfamily [IPR012337]", "Ribonuclease H1, N-terminal domain superfamily [IPR037056]", "Ribonuclease HII, helix-loop-helix cap domain superfamily [IPR023160]", "Ribonuclease III, endonuclease domain superfamily [IPR036389]", "Ribonuclease T2-like superfamily [IPR036430]", "Ribonuclease Z/Hydroxyacylglutathione hydrolase-like [IPR036866]", "Ribonucleotide reductase R1 subunit, N-terminal [IPR008926]", "Ribonucleotide reductase-like [IPR012348]", "Ribosomal L15/L27a, N-terminal [IPR027386]", "Ribosomal L18e/L15P superfamily [IPR036227]", "Ribosomal RNA-processing protein 8, N-terminal domain [IPR042036]", "Ribosomal protein L1, 3-layer alpha/beta-sandwich [IPR016095]", "Ribosomal protein L1-like [IPR023674]", "Ribosomal protein L10-like domain superfamily [IPR043141]", "Ribosomal protein L10e/L16 superfamily [IPR036920]", "Ribosomal protein L11, C-terminal domain superfamily [IPR036769]", "Ribosomal protein L11/L12, N-terminal domain superfamily [IPR036796]", "Ribosomal protein L13 superfamily [IPR036899]", "Ribosomal protein L14 superfamily [IPR036853]", "Ribosomal protein L15e core domain superfamily [IPR024794]", "Ribosomal protein L19 superfamily [IPR038657]", "Ribosomal protein L19/L19e superfamily [IPR035970]", "Ribosomal protein L19/L19e, domain 1 [IPR015972]", "Ribosomal protein L2, domain 2 [IPR014722]", "Ribosomal protein L2, domain 3 [IPR014726]", "Ribosomal protein L21 superfamily [IPR036948]", "Ribosomal protein L22/L17 superfamily [IPR036394]", "Ribosomal protein L22e superfamily [IPR038526]", "Ribosomal protein L23/L15e core domain superfamily [IPR012678]", "Ribosomal protein L24e/L24 superfamily [IPR038630]", "Ribosomal protein L25/Gln-tRNA synthetase, N-terminal [IPR020056]", "Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily [IPR011035]", "Ribosomal protein L27e superfamily [IPR038655]", "Ribosomal protein L28/L24 superfamily [IPR037147]", "Ribosomal protein L29/L35 superfamily [IPR036049]", "Ribosomal protein L3, domain 3, archaeal type superfamily [IPR044892]", "Ribosomal protein L30, ferredoxin-like fold domain superfamily [IPR036919]", "Ribosomal protein L31e domain superfamily [IPR023621]", "Ribosomal protein L32e superfamily [IPR036351]", "Ribosomal protein L35A superfamily [IPR038661]", "Ribosomal protein L36e domain superfamily [IPR038097]", "Ribosomal protein L37ae/L37e [IPR011331]", "Ribosomal protein L38e superfamily [IPR038464]", "Ribosomal protein L4 domain superfamily [IPR023574]", "Ribosomal protein L5 domain superfamily [IPR022803]", "Ribosomal protein L6, alpha-beta domain superfamily [IPR036789]", "Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like [IPR014719]", "Ribosomal protein L7/L12, oligomerisation domain superfamily [IPR036235]", "Ribosomal protein L9, N-terminal domain superfamily [IPR036935]", "Ribosomal protein L9/RNase H1, N-terminal [IPR009027]", "Ribosomal protein P1/P2, N-terminal domain [IPR038716]", "Ribosomal protein S10 domain superfamily [IPR036838]", "Ribosomal protein S11 superfamily [IPR036967]", "Ribosomal protein S13-like, H2TH [IPR010979]", "Ribosomal protein S17e-like superfamily [IPR036401]", "Ribosomal protein S19/S15, superfamily [IPR023575]", "Ribosomal protein S2, flavodoxin-like domain superfamily [IPR023591]", "Ribosomal protein S21e superfamily [IPR038579]", "Ribosomal protein S3, C-terminal domain superfamily [IPR036419]", "Ribosomal protein S4e, central domain superfamily [IPR038237]", "Ribosomal protein S5 domain 2-type fold [IPR020568]", "Ribosomal protein S5 domain 2-type fold, subgroup [IPR014721]", "Ribosomal protein S7 domain superfamily [IPR036823]", "Ribosomal protein S8 superfamily [IPR035987]", "Ribosomal protein S8e subdomain, eukaryotes [IPR042563]", "Ribosome maturation protein SBDS, N-terminal domain superfamily [IPR036786]", "Ribosome maturation protein Sdo1/SBDS, central domain superfamily [IPR037188]", "Ribosome-associated complex head domain superfamily [IPR042569]", "Ribulose-phosphate binding barrel [IPR011060]", "Ricin B-like lectins [IPR035992]", "RmlC-like cupin domain superfamily [IPR011051]", "RmlC-like jelly roll fold [IPR014710]", "Rossmann-like alpha/beta/alpha sandwich fold [IPR014729]", "Rudiment single hybrid motif [IPR011054]", "RuvA domain 2-like [IPR010994]", "RuvBL1/2, DNA/RNA binding domain [IPR042487]", "S-adenosyl-L-methionine-dependent methyltransferase [IPR029063]", "S-adenosylmethionine synthetase superfamily [IPR022636]", "S15/NS1, RNA-binding [IPR009068]", "SAP domain superfamily [IPR036361]", "SCP2 sterol-binding domain superfamily [IPR036527]", "SGNH hydrolase superfamily [IPR036514]", "SH2 domain superfamily [IPR036860]", "SH3-like domain superfamily [IPR036028]", "SKP1-like, dimerisation domain superfamily [IPR036296]", "SKP1/BTB/POZ domain superfamily [IPR011333]", "SMAD/FHA domain superfamily [IPR008984]", "SMCs flexible hinge superfamily [IPR036277]", "SNARE [IPR010989]", "SNF2-like, N-terminal domain superfamily [IPR038718]", "SNase-like, OB-fold superfamily [IPR035437]", "SOS response associated peptidase-like [IPR036590]", "SPOC-like, C-terminal domain superfamily [IPR016194]", "SRA-YDG superfamily [IPR036987]", "SRCR-like domain superfamily [IPR036772]", "SRP/SRP receptor, N-terminal [IPR036225]", "SRP68, N-terminal domain superfamily [IPR038253]", "SSRP1 domain superfamily [IPR038167]", "START-like domain superfamily [IPR023393]", "STAT transcription factor, DNA-binding, N-terminal [IPR012345]", "STAT transcription factor, N-terminal domain superfamily [IPR036535]", "STAT transcription factor, coiled coil [IPR015988]", "SUI1 domain superfamily [IPR036877]", "SWAP/Surp superfamily [IPR035967]", "SWIB/MDM2 domain superfamily [IPR036885]", "Scavenger mRNA decapping enzyme, N-terminal [IPR011145]", "Schlafen, AlbA_2 domain superfamily [IPR038461]", "ScpA-like, C-terminal [IPR023093]", "Sec1-like superfamily [IPR036045]", "Sec1-like, domain 1 [IPR043154]", "Sec1-like, domain 2 [IPR027482]", "Sec1-like, domain 3a [IPR043127]", "Sec23/Sec24 helical domain superfamily [IPR036175]", "Sec7 domain superfamily [IPR035999]", "Sec7, C-terminal domain superfamily [IPR023394]", "SecY domain superfamily [IPR023201]", "Secretoglobin superfamily [IPR035960]", "Serine carboxypeptidase S28, SKS domain [IPR042269]", "Serine-tRNA synthetase, type1, N-terminal domain superfamily [IPR042103]", "Serpin superfamily [IPR036186]", "Serpin superfamily, domain 1 [IPR042178]", "Serpin superfamily, domain 2 [IPR042185]", "Sialidase superfamily [IPR036278]", "Signal recognition particle SRP54, N-terminal domain superfamily [IPR042101]", "Signal recognition particle, SRP54 subunit, M-domain superfamily [IPR036891]", "Signal recognition particle, SRP9/SRP14 subunit [IPR009018]", "Signal recognition particle, subunit SRP19-like superfamily [IPR036521]", "Sin3 associated polypeptide p18 superfamily [IPR042534]", "Single hybrid motif [IPR011053]", "Sirtuin, catalytic core small domain superfamily [IPR026591]", "Six-bladed beta-propeller, TolB-like [IPR011042]", "Six-hairpin glycosidase superfamily [IPR008928]", "Six-hairpin glycosidase-like superfamily [IPR012341]", "Smac/DIABLO-like superfamily [IPR009062]", "Sodium/potassium-transporting ATPase subunit beta superfamily [IPR038702]", "Sodium:dicarboxylate symporter superfamily [IPR036458]", "Sodium:neurotransmitter symporter superfamily [IPR037272]", "Soluble quinoprotein glucose/sorbosone dehydrogenase [IPR011041]", "Spermadhesin, CUB domain superfamily [IPR035914]", "Spermidine synthase, tetramerisation domain superfamily [IPR037163]", "Spt6, Death-like domain [IPR042066]", "Stathmin superfamily [IPR036002]", "Sterile alpha motif/pointed domain superfamily [IPR013761]", "Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily [IPR027477]", "Succinyl-CoA synthetase-like [IPR016102]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain superfamily [IPR042568]", "Sushi/SCR/CCP superfamily [IPR035976]", "TAP42/TAP46-like superfamily [IPR038511]", "TBP domain superfamily [IPR012295]", "TCP-1-like chaperonin intermediate domain superfamily [IPR027410]", "TEL2, C-terminal domain superfamily [IPR038528]", "TFIIIC, subcomplex tauA subunit Sfc1, triple barrel domain superfamily [IPR042536]", "TFIIS/LEDGF domain superfamily [IPR035441]", "TGS-like [IPR012676]", "TGS-like domain superfamily [IPR023192]", "TRAF-like [IPR008974]", "TROVE domain superfamily [IPR037214]", "Talin, central domain superfamily [IPR036476]", "Tautomerase/MIF superfamily [IPR014347]", "Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid [IPR008930]", "Tetraspanin, EC2 domain superfamily [IPR008952]", "Tetratricopeptide-like helical domain superfamily [IPR011990]", "Tex-like domain superfamily [IPR023323]", "Tex-like protein, HTH domain superfamily [IPR023319]", "Thiamin diphosphate-binding fold [IPR029061]", "Thiolase-like [IPR016039]", "Thioredoxin-like superfamily [IPR036249]", "Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily [IPR018163]", "Thymidylate synthase/dCMP hydroxymethylase superfamily [IPR036926]", "Tim10-like domain superfamily [IPR035427]", "Transcription elongation factor S-II, central domain superfamily [IPR036575]", "Transcription factor EnY2 superfamily [IPR038212]", "Transcription termination and cleavage factor, C-terminal domain superfamily [IPR038192]", "Transcriptional regulator TACO1-like, domain 3 [IPR026564]", "Transferrin receptor-like, dimerisation domain superfamily [IPR036757]", "Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II [IPR009014]", "Translation Initiation factor eIF- 4e-like [IPR023398]", "Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal [IPR009001]", "Translation elongation factor EF1B/ribosomal protein S6 [IPR014717]", "Translation elongation factor eEF-1beta-like superfamily [IPR036219]", "Translation initiation factor 2, alpha subunit, C-terminal [IPR024055]", "Translation initiation factor 2, alpha subunit, middle domain superfamily [IPR024054]", "Translation initiation factor 3, subunit 12, N-terminal, eukaryotic [IPR016020]", "Translation initiation factor IF-2, domain 3 superfamily [IPR036925]", "Translation initiation factor IF2/IF5, N-terminal [IPR016189]", "Translation initiation factor IF2/IF5, zinc-binding [IPR016190]", "Translation initiation factor eIF-2B subunit alpha, N-terminal [IPR042528]", "Translation protein SH3-like domain superfamily [IPR008991]", "Translation protein, beta-barrel domain superfamily [IPR009000]", "Translin superfamily [IPR036081]", "Translin, C-terminal [IPR016069]", "Translin, N-terminal [IPR016068]", "Trimeric LpxA-like superfamily [IPR011004]", "Triosephosphate isomerase superfamily [IPR035990]", "Tubulin binding cofactor A superfamily [IPR036126]", "Tubulin, C-terminal [IPR023123]", "Tubulin/FtsZ, C-terminal [IPR008280]", "Tubulin/FtsZ, GTPase domain superfamily [IPR036525]", "Tubulin/FtsZ-like, C-terminal domain [IPR037103]", "UBA-like superfamily [IPR009060]", "UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily [IPR036220]", "UROD/MetE-like superfamily [IPR038071]", "Ubiquitin activating enzyme, alpha domain superfamily [IPR023318]", "Ubiquitin-activating enzyme E1, C-terminal domain superfamily [IPR038252]", "Ubiquitin-activating enzyme E1, FCCH domain superfamily [IPR042302]", "Ubiquitin-activating enzyme E1, SCCH domain [IPR042063]", "Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 [IPR042449]", "Ubiquitin-activating enzyme [IPR035985]", "Ubiquitin-conjugating enzyme/RWD-like [IPR016135]", "Ubiquitin-like domain superfamily [IPR029071]", "Ufd1-like, Nn domain [IPR042299]", "Uracil-DNA glycosylase-like domain superfamily [IPR036895]", "Ureohydrolase domain superfamily [IPR023696]", "V-type ATP synthase c/d subunit, domain 3 superfamily [IPR044911]", "V-type ATP synthase subunit c/d subunit superfamily [IPR036079]", "V-type ATPase subunit C/d [IPR035067]", "V-type ATPase subunit E, C-terminal domain superfamily [IPR038495]", "VASP tetramerisation domain superfamily [IPR038023]", "VPS9 domain superfamily [IPR037191]", "Vacuolar ATP synthase subunit C superfamily [IPR036132]", "Vacuolar protein sorting-associated protein 33, domain 3b [IPR043155]", "Vacuolar protein sorting-associated protein 35, C-terminal [IPR042491]", "Vacuolar protein sorting-associated protein IST1-like [IPR042277]", "Valyl-tRNA synthetase, tRNA-binding arm superfamily [IPR037118]", "Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain [IPR009008]", "Vanillyl-alcohol oxidase, C-terminal subdomain 2 [IPR016171]", "Vitamin B12-dependent methionine synthase, activation domain superfamily [IPR037010]", "Vps16, C-terminal domain superfamily [IPR038132]", "Vps53, C-terminal domain superfamily [IPR038260]", "WD40-repeat-containing domain superfamily [IPR036322]", "WD40/YVTN repeat-like-containing domain superfamily [IPR015943]", "WGR domain superfamily [IPR036930]", "WW domain superfamily [IPR036020]", "WWE domain superfamily [IPR037197]", "Winged helix DNA-binding domain superfamily [IPR036390]", "Winged helix-like DNA-binding domain superfamily [IPR036388]", "XPC-binding domain superfamily [IPR036353]", "YEATS superfamily [IPR038704]", "YebC-like [IPR029072]", "YjeF N-terminal domain superfamily [IPR036652]", "YqgF/RNase H-like domain superfamily [IPR037027]", "Zinc finger C2H2 superfamily [IPR036236]", "Zinc finger, CCCH-type superfamily [IPR036855]", "Zinc finger, CCHC-type superfamily [IPR036875]", "Zinc finger, FYVE/PHD-type [IPR011011]", "Zinc finger, PARP-type superfamily [IPR036957]", "Zinc finger, RING/FYVE/PHD-type [IPR013083]", "Zinc finger, RanBP2-type superfamily [IPR036443]", "Zinc finger, Sec23/Sec24-type superfamily [IPR036174]", "Zinc finger, ZZ-type superfamily [IPR043145]", "Zinc-binding ribosomal protein [IPR011332]", "dUTPase-like superfamily [IPR036157]", "eRF1, domain 1 [IPR024049]", "eRF1, domain 2 superfamily [IPR042226]", "p53-like tetramerisation domain superfamily [IPR036674]", "p53-like transcription factor, DNA-binding [IPR008967]", "p53/RUNT-type transcription factor, DNA-binding domain superfamily [IPR012346]", "ssDNA-binding transcriptional regulator [IPR009044]", "tRNA (guanine-N1-)-methyltransferase, N-terminal [IPR029026]", "tRNA methyltransferase TRM10-type domain superfamily [IPR038459]", "tRNA modification GTPase MnmE domain 2 [IPR027368]", "tRNA-splicing ligase RtcB-like superfamily [IPR036025]", "tRNAHis guanylyltransferase Thg1 superfamily [IPR038469]", "von Willebrand factor A-like domain superfamily [IPR036465]"], "available_proteins": ["AAAS", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABHD10", "ABHD12", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR6", "ADAM17", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK6", "AKAP1", "AKAP13", "AKAP17A", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "ALYREF", "ANAPC1", "ANAPC5", "ANAPC7", "ANK3", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG4B", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5H", "ATP5O", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATXN10", "BABAM1", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAT2", "BCL2L12", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPTF", "BRCA1", "BRD2", "BROX", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BZW1", "C1QBP", "CACYBP", "CAD", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CDC23", "CDC27", "CDC34", "CDC37", "CDC42", "CDC5L", "CDC73", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CEBPZ", "CECR2", "CELF1", "CENPB", "CEP170", "CERS2", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHD4", "CHERP", "CHID1", "CHKA", "CHORDC1", "CHRAC1", "CHTF18", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLINT1", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT10", "CNOT3", "CNOT6", "CNOT7", "CNOT9", "CNP", "COA7", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPZ1", "CORO1B", "CORO1C", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2B", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYP51A1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF13", "DCAF7", "DCAKD", "DCPS", "DCTN1", "DCXR", "DDB1", "DDI2", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DENR", "DERL1", "DFFA", "DGCR8", "DGUOK", "DHCR24", "DHFR", "DHPS", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DOHH", "DPF2", "DPH2", "DPM1", "DPP9", "DPYSL2", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "ECE1", "ECH1", "ECHS1", "ECI2", "EDC3", "EDC4", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3B", "EIF3E", "EIF3G", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELOA", "ELOB", "ELP1", "ELP2", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "ENY2", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERH", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM120B", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FEN1", "FERMT2", "FH", "FKBP10", "FKBP14", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FOXK1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCN1", "GDI1", "GDI2", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GIGYF2", "GINS1", "GINS4", "GLA", "GLB1", "GLDC", "GLE1", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GNS", "GORASP2", "GOT1", "GOT2", "GPD2", "GPI", "GPRASP2", "GPS1", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGFL2", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIC2", "HIF1AN", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMCES", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOXA10", "HP1BP3", "HPRT1", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IDE", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP3", "IGF2R", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMPDH2", "INF2", "INTS11", "INTS14", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRS4", "ISOC1", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC2", "KLC4", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRR1", "KYAT3", "L2HGDH", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LDAH", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3BP", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LYAR", "LYPLA1", "MACF1", "MAGED2", "MAGT1", "MAP2K1", "MAPRE1", "MAPRE2", "MARC1", "MARK2", "MARS", "MAT2A", "MATR3", "MAU2", "MBD3", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED16", "METAP2", "METTL13", "MFN1", "MFN2", "MGEA5", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MMAB", "MMS19", "MOB4", "MOGS", "MORF4L1", "MOV10", "MPI", "MPP2", "MPP6", "MPRIP", "MPST", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL38", "MRPL39", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL9", "MRPS11", "MRPS2", "MRPS25", "MRPS27", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MYBBP1A", "MYEF2", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPG", "NCBP1", "NCL", "NCOA5", "NDRG3", "NDUFA10", "NDUFA9", "NDUFAF1", "NDUFAF7", "NDUFS1", "NDUFS3", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4L", "NEK9", "NENF", "NEU1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL11", "NOL8", "NOL9", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NPTN", "NRBP1", "NRDC", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT12", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP98", "NUTF2", "NVL", "NXF1", "OAT", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OSBP", "OSBPL11", "OSBPL6", "OSBPL9", "OTUB1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAFAH1B1", "PAFAH1B3", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARN", "PARP1", "PARP2", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCMT1", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF6", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIR", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLAA", "PLBD2", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNO1", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1R10", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PPP6R3", "PPT1", "PQBP1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG2", "PSPC1", "PTBP1", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTRH2", "PTRHD1", "PUF60", "PUM3", "PUS1", "PUS7", "PWP1", "PWP2", "PYCR1", "PYCR2", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RABGGTA", "RABL6", "RAC1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM34", "RBM39", "RBM4", "RBM45", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "RECQL5", "REPS1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIF1", "RINT1", "RIOK2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF114", "RNF20", "RNF40", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA3", "RPAP3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPP30", "RPRD1A", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS8", "RPS9", "RPSA", "RRM1", "RRM2", "RRP12", "RRP7A", "RRP8", "RRP9", "RSF1", "RSL1D1", "RTCB", "RTN4IP1", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART3", "SBDS", "SCAF8", "SCCPDH", "SCFD1", "SCO1", "SCP2", "SCPEP1", "SCRIB", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERPINB6", "SERPINH1", "SET", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3B1", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SIN3A", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC3A2", "SLC6A15", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMU1", "SMYD3", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNX1", "SNX12", "SNX2", "SNX3", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SQLE", "SQSTM1", "SRCAP", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAG2", "STARD3", "STAT3", "STEAP3", "STIP1", "STMN1", "STOML2", "STRAP", "STRBP", "STRN4", "STUB1", "STX12", "STX7", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "TACO1", "TAF15", "TAGLN2", "TALDO1", "TAP1", "TAP2", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCE", "TBL2", "TBL3", "TCAF1", "TCEA1", "TCERG1", "TCF25", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TEX10", "TFAM", "TFRC", "THG1L", "THOC1", "THOC3", "THOC6", "THOP1", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TK1", "TKT", "TLN1", "TMED7", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX4", "TNPO1", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOX4", "TP53", "TP53BP1", "TPD52L2", "TPI1", "TPP1", "TPP2", "TPT1", "TRA2A", "TRA2B", "TRAP1", "TRAPPC5", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRMU", "TRNT1", "TROVE2", "TSC2", "TSFM", "TSG101", "TSN", "TSPAN6", "TSTA3", "TTC1", "TTC19", "TTC21B", "TTC26", "TTC37", "TTC38", "TTC4", "TTK", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBL5", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UCHL5", "UFC1", "UFD1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF3B", "UQCR10", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USO1", "USP10", "USP14", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIRMA", "VPS16", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR43", "WDR45B", "WDR46", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIZ", "WRAP53", "XAB2", "XPNPEP1", "XPO1", "XPO4", "XPO5", "XPO7", "XRCC1", "XRCC5", "XRCC6", "YARS", "YARS2", "YBX1", "YEATS2", "YEATS4", "YKT6", "YLPM1", "YME1L1", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBTB10", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3HAV1", "ZCCHC3", "ZFR", "ZFYVE16", "ZNF148", "ZNF281", "ZNF638", "ZNF687", "ZRANB2"], "leading_proteins": ["ABCB1", "ACADS", "ADI1", "AIFM1", "AIMP2", "ALDH1A2", "ALDH1B1", "ALDH3A2", "ALYREF", "ANK3", "ANKLE2", "ANXA1", "ANXA11", "ANXA7", "ATP13A1", "ATP1B3", "BAIAP2", "CACYBP", "CALR", "CALU", "CAPN2", "CBX1", "CBX3", "CDC34", "CERS2", "CIRBP", "CLGN", "CLUH", "CNOT6", "CNOT7", "COPZ1", "CPSF6", "CPVL", "CRTAP", "CSTF2", "CTSA", "CYB5B", "CYB5D2", "CYB5R1", "DAZAP1", "DGCR8", "DHCR24", "DHPS", "DNAJC10", "DNAJC2", "DNAJC3", "DNAJC8", "DNAJC9", "ECE1", "EEF1B2", "EIF4H", "ELOA", "EPHA7", "EPHX1", "ERP29", "ETFA", "ETFDH", "EWSR1", "EXO1", "FAF2", "FKBP14", "FKBP7", "FUS", "GAA", "GBA", "GGCX", "GLA", "GLB1", "GNAI2", "GRSF1", "GSTO1", "HADH", "HADHA", "HDGFL2", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPR", "HSDL1", "HSDL2", "HSPB1", "HTRA2", "KDSR", "KLC4", "LDAH", "LEMD3", "LMNB1", "LMNB2", "LNPEP", "MAPRE2", "MGEA5", "MIPEP", "MPP2", "MPP6", "MRPL10", "MRTO4", "MSN", "MTX1", "MTX2", "MYL6", "NADK2", "NAGLU", "NAMPT", "NAP1L1", "NNT", "NOL8", "NONO", "NPEPPS", "NRDC", "NSFL1C", "NT5C3B", "NUCB1", "NUCB2", "NUP35", "P3H4", "P4HA1", "P4HA2", "P4HB", "PAK4", "PCYOX1", "PDCL3", "PDE12", "PFDN5", "PFN1", "PHC2", "PIR", "PITHD1", "PON2", "POR", "PPID", "PPT1", "PRCP", "PRPF3", "PSIP1", "PSMA6", "PSMB1", "PSMB2", "PSMB4", "PSMB6", "PSMB7", "PSME2", "PSPC1", "PTGES2", "PTGES3", "PTGR1", "PUF60", "QSOX2", "RAVER1", "RBM10", "RBM14", "RBM17", "RBM22", "RBM25", "RBM27", "RBM4", "RBM5", "RBM8A", "RBMX", "RCN2", "RDX", "RFC1", "RFC2", "RP2", "RPS20", "RPS3", "RPSA", "RTN4IP1", "S100A10", "SAMHD1", "SCCPDH", "SCFD1", "SCO1", "SCP2", "SCPEP1", "SDF4", "SET", "SFPQ", "SH3BGRL2", "SIRT2", "SLC18B1", "SLC25A10", "SLC25A11", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A32", "SLC25A33", "SLC25A4", "SPR", "SQSTM1", "SRI", "SRP9", "SRSF1", "SRSF10", "SRSF3", "SRSF9", "STARD3", "STX12", "SUPT6H", "SYNCRIP", "TAF15", "TCEA1", "TCF25", "TDP2", "THOC1", "TIA1", "TIAL1", "TMED7", "TMX4", "TOE1", "TRA2B", "TSG101", "TTC19", "TTC26", "TTC38", "TUBB", "TUBB4B", "TUBB6", "TXNDC12", "U2AF2", "UBAP2L", "UBE2S", "UNC119B", "UQCRC1", "UQCRC2", "UTP6", "VAMP7", "VDAC1", "VPS33A", "VPS33B", "YWHAG", "YWHAH", "YWHAQ", "ZADH2", "ZC3H7A"]} \ No newline at end of file diff --git a/interpro_ptm/advanced/idx2term.json b/interpro_ptm/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/basic/idx2term.json b/interpro_ptm/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/consensus.joblib b/interpro_ptm/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..a144667c3b2c580fdc6f6f841a49b9ac0d5e4a98 --- /dev/null +++ b/interpro_ptm/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:0fe1773da7ebc2ddc111d19080c94c5b63eef66a86bc56ba787aa10620cde823 +size 54415 diff --git a/interpro_ptm/df_merge.tsv b/interpro_ptm/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_ptm/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_ptm/metrics.json b/interpro_ptm/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..ffac594347a467d2bdba5968427fd5740f9cf71a --- /dev/null +++ b/interpro_ptm/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2454, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 2.0 +} \ No newline at end of file diff --git a/interpro_ptm/paths.json b/interpro_ptm/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..842baf272780dabad8729a4ce296cc8be2adcc72 --- /dev/null +++ b/interpro_ptm/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_ptm/fragment/C340/C340_val_log2fc"} \ No newline at end of file diff --git a/interpro_ptm/result.tsv b/interpro_ptm/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..911c0f98110fcfc0055bf4e7c9370c039a6363c6 --- /dev/null +++ b/interpro_ptm/result.tsv @@ -0,0 +1 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size diff --git a/interpro_ptm/selections.json b/interpro_ptm/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..ba167973c9dfeba13469336bf16fd928d590fc8f --- /dev/null +++ b/interpro_ptm/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["EGF-type aspartate/asparagine hydroxylation site [IPR000152]", "P-type ATPase, phosphorylation site [IPR018303]", "Phosphopantetheine attachment site [IPR006162]", "Translation elongation factor, IF5A, hypusine site [IPR019769]"], "available_proteins": ["ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "EIF5A", "FASN", "SLIT2"], "leading_proteins": []} \ No newline at end of file diff --git a/interpro_repeat/advanced/idx2term.json b/interpro_repeat/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6dce773863970e13dd9ed6c0019ab4c4e97de280 --- /dev/null +++ b/interpro_repeat/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Mitochondrial substrate/solute carrier [IPR018108]"} \ No newline at end of file diff --git a/interpro_repeat/advanced/plot_0.png b/interpro_repeat/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..14223ccfd12d6df9882a778241f5f277a1bb1547 --- /dev/null +++ b/interpro_repeat/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:a7bfb35fc7735e4c778267de081618b0d1ba5beb105165ce2c181c25dcff8bb9 +size 183752 diff --git a/interpro_repeat/basic/idx2term.json b/interpro_repeat/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..89347332fd727e794f5dc31a862dff01327a7f4e --- /dev/null +++ b/interpro_repeat/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Mitochondrial substrate/solute carrier [IPR018108]", "1": "Tetratricopeptide repeat [IPR019734]"} \ No newline at end of file diff --git a/interpro_repeat/basic/plot_0.png b/interpro_repeat/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..6fe294ea88431bcf58f7e25a424a70cf07a3962d --- /dev/null +++ b/interpro_repeat/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:3beaee0af66b7dd80934d2b76d60add635266d96312679114e8211165644c90b +size 146179 diff --git a/interpro_repeat/basic/plot_1.png b/interpro_repeat/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..b1c4c69f74cbd8f4bc8243fab4b48c975cb816f9 --- /dev/null +++ b/interpro_repeat/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:61e8ebe40d5c1e55f8a8b13eb0a943be3d16af758be0f463e73e7e3aa9a9e5e7 +size 146982 diff --git a/interpro_repeat/consensus.joblib b/interpro_repeat/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..f1f9b2ca1fb27b721b19dea811beb6055c3ea09f --- /dev/null +++ b/interpro_repeat/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:9a4d2a464a2d38c0fffa18d0d022bcfa53a19a541d1993c7b76047a032fc7f30 +size 59207 diff --git a/interpro_repeat/df_merge.tsv b/interpro_repeat/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..6bf20ce0473c257a5e82a6a88878eb630f878827 --- /dev/null +++ b/interpro_repeat/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Mitochondrial substrate/solute carrier [IPR018108] 11 18 2.7586513649843054 0.0058040418852931 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 1.0 0.0142466262053111 0.0058560324261939 0.002055769463525 1.0422745207145842e-06 diff --git a/interpro_repeat/metrics.json b/interpro_repeat/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..6d3dd7508acc85a5bf718cdc1086306bd94a53d0 --- /dev/null +++ b/interpro_repeat/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2454, + "annotations_size": 68, + "title": "Average number of proteins per term", + "value": 5.25 +} \ No newline at end of file diff --git a/interpro_repeat/paths.json b/interpro_repeat/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..9123f2757d699a78f7d7ca1505c58ad7998e7e3e --- /dev/null +++ b/interpro_repeat/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_repeat/fragment/C340/C340_val_log2fc"} \ No newline at end of file diff --git a/interpro_repeat/result.tsv b/interpro_repeat/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..e887eb4072160312d24092e80a4ba68a252874af --- /dev/null +++ b/interpro_repeat/result.tsv @@ -0,0 +1,6 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Mitochondrial substrate/solute carrier [IPR018108] 0.7241678660715116 2.7586513649843054 0.0058040418852931 0.3268752847157973 0.0549920379066506 18 Q9Y619,O43772,Q9BSK2,Q9HC21,Q02978,Q6NUK1,O43808,Q9H2D1,P12235,Q9UBX3,Q70HW3 11 +Sel1-like repeat [IPR006597] 0.8189233278955945 1.511982018594934 0.1305384369997404 0.9999260349843508 0.3346281925036551 2 Q96BR5 1 +Annexin repeat [IPR018502] 0.5712647991307751 0.791453646671129 0.4286793152489159 1.0 0.6336998573244843 5 P20073,P04083,P50995 3 +Tetratricopeptide repeat [IPR019734] 0.3403456521181746 0.6999830513126302 0.4839378890975272 1.0 0.675583048225861 44 O15460,Q9NSK0,Q08752,A0AVF1,Q6DKK2 5 +Hexapeptide repeat [IPR001451] 0.3813213703099515 0.0703378564614251 0.943924752008799 1.0 0.9580131811432586 2 Q96IJ6 1 diff --git a/interpro_repeat/selections.json b/interpro_repeat/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..58619bee0462b9ca28d8bc6dc69b4bf240d6856b --- /dev/null +++ b/interpro_repeat/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Ankyrin repeat [IPR002110]", "Annexin repeat [IPR018502]", "Armadillo [IPR000225]", "Atypical Arm repeat [IPR032413]", "BIR repeat [IPR001370]", "Beta-propeller repeat TECPR [IPR006624]", "Calponin repeat [IPR000557]", "Cation-independent mannose-6-phosphate receptor repeat [IPR000479]", "Chromosome region maintenance repeat [IPR041123]", "Clathrin, heavy chain, propeller repeat [IPR022365]", "Clathrin, heavy chain/VPS, 7-fold repeat [IPR000547]", "Cysteine-rich Golgi apparatus protein 1 repeat [IPR001893]", "Cysteine-rich Golgi apparatus protein 1 repeat, eukaryote [IPR017873]", "Exportin-1, repeat 2 [IPR041235]", "Exportin-1, repeat 3 [IPR040485]", "Filamin/ABP280 repeat [IPR001298]", "Filamin/ABP280 repeat-like [IPR017868]", "G-protein beta WD-40 repeat [IPR020472]", "GTF2I-like repeat [IPR004212]", "HAT (Half-A-TPR) repeat [IPR003107]", "HEAT repeat [IPR000357]", "HEAT repeat associated with sister chromatid cohesion protein [IPR026003]", "HEAT, type 2 [IPR021133]", "HUWE1/Rev1, ubiquitin binding region [IPR025527]", "Hexapeptide repeat [IPR001451]", "Hs1/Cortactin [IPR003134]", "Huntingtin, middle-repeat [IPR024613]", "Importin repeat 4 [IPR041653]", "Importin repeat 6 [IPR041389]", "Importin repeat [IPR040928]", "KI67R [IPR012568]", "Kelch repeat type 1 [IPR006652]", "Kinesin light chain repeat [IPR015792]", "Leucine rich repeat 4 [IPR025875]", "Leucine-rich repeat [IPR001611]", "Leucine-rich repeat, cysteine-containing subtype [IPR006553]", "Leucine-rich repeat, typical subtype [IPR003591]", "Low-density lipoprotein (LDL) receptor class A repeat [IPR002172]", "Microtubule associated protein, tubulin-binding repeat [IPR001084]", "Mitochondrial substrate/solute carrier [IPR018108]", "NHL repeat [IPR001258]", "Nebulin repeat [IPR000900]", "Neuraxin/MAP1B repeat [IPR000102]", "P120R repeat [IPR012586]", "PBS lyase HEAT-like repeat [IPR004155]", "PFTB repeat [IPR001330]", "Paired amphipathic helix [IPR003822]", "Pentatricopeptide repeat [IPR002885]", "Plectin repeat [IPR001101]", "Proteasome/cyclosome repeat [IPR002015]", "Protein of unknown function DM15 [IPR006607]", "Protein prenyltransferase, alpha subunit [IPR002088]", "Proteinase inhibitor I27, calpastatin [IPR001259]", "Pumilio RNA-binding repeat [IPR001313]", "Putative TPR-like repeat [IPR031545]", "Pyrrolo-quinoline quinone repeat [IPR002372]", "RNA helicase p68 repeat [IPR012587]", "RNA polymerase II, heptapeptide repeat, eukaryotic [IPR000684]", "Regulator of chromosome condensation, RCC1 [IPR000408]", "Sel1-like repeat [IPR006597]", "Spectrin repeat [IPR002017]", "Spectrin/alpha-actinin [IPR018159]", "Tetratricopeptide repeat 1 [IPR001440]", "Tetratricopeptide repeat 2 [IPR013105]", "Tetratricopeptide repeat [IPR019734]", "Vesicle tethering protein p115, armadillo tether-repeat [IPR041209]", "WD40 repeat [IPR001680]", "Wolframin, Sel1-like repeat [IPR045458]"], "available_proteins": ["AAAS", "ACTN1", "ACTN4", "AIP", "ANAPC5", "ANAPC7", "ANK3", "ANKHD1", "ANKRD17", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP2B1", "ARMC6", "ARMCX3", "ARPC1A", "ARPC1B", "ASPH", "BIRC6", "BOP1", "BUB3", "CAST", "CDC23", "CDC27", "CHAF1B", "CKAP5", "CLASP1", "CLPB", "CLTC", "CNN2", "CNN3", "CNOT10", "CNOT6", "COA7", "COPA", "COPB2", "CORO1B", "CORO1C", "CRNKL1", "CSTF1", "CSTF3", "CTNNB1", "CTNND1", "CTTN", "DCAF13", "DCAF7", "DDX5", "DNAAF5", "DNAJC3", "DNAJC7", "DOHH", "DSP", "DST", "DYNC1I2", "EDC4", "EIF2B5", "EIF3I", "ELP2", "EMC1", "EMC2", 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1.0902328246323953e-05 +Protein targeting 22 90 3.0173096873165264 0.0025502912230657 30.48543689320388 111.54126213592232 1.595466660966077 0.3336055854889273 10.683999539888966 11.70327920021055 1.673091584234216 0.3988264387816677 1.0 0.1192613506521148 0.0007232310681177 0.00037790881714 7.140522729643657e-05 +Anion transmembrane transport 17 32 2.996571508703872 0.0027303419310578 18.02912621359223 42.29854368932039 1.9137296804814252 0.1915609440243116 8.771596162415214 5.032004157423188 1.8922368499585025 0.2935375719655638 1.0 0.1008495778431075 0.0234054255443748 0.0056398831246448 2.2862914665466935e-05 +Alcohol biosynthetic process 8 25 2.92683107449974 0.0034243481986595 9.344660194174756 36.09466019417476 1.0726679306851277 0.3539682718575088 3.792896481514287 3.1078151772256564 1.1587776417647702 0.3419459456532639 1.0 0.3467229085425889 0.0002051469607709 0.000259969323856 0.0031651417497532 +Circulatory system process 10 58 2.892299832947769 0.003824327857739 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0.424605725297311 4.713262264354627 5.1877801804871915 1.1130427360157376 0.3580104692277669 1.0 0.4701418449361933 0.0016933870815106 0.0043991787336563 0.0235993900287678 +Protein targeting to mitochondrion 11 40 2.794511688508691 0.0051978161724131 14.980582524271844 46.067961165048544 1.7767024064550243 0.249920045184344 6.494927942714517 4.708517660750424 1.5433015545903224 0.3384144763122346 1.0 0.0085976741283889 0.0016161749700128 4.818008338446824e-05 1.684086605424508e-05 +Lytic vacuole organization 5 18 2.778270544054384 0.0054649095541432 8.677184466019417 23.79368932038835 1.067589638534915 0.1668002350701783 2.8744208086829883 3.077266940940983 2.0111064761459874 0.2496786569477077 1.0 0.2516504230112798 0.0203848430395501 0.0031264397563519 0.0021062451144682 +Protein transmembrane transport 6 21 2.6822943524690857 0.0073119091885829 8.992718446601941 25.191747572815533 1.6893060623430327 0.189108476986505 4.473486660459625 2.7693940759543416 1.4682653164365471 0.2783169275392022 1.0 0.0020640692536444 0.0001546792596973 0.0016490180911792 0.0035335621175587 +Protein localization to mitochondrion 12 48 2.666646192419419 0.0076612277963896 18.37621359223301 58.6747572815534 1.743973973786015 0.2835887708870952 7.329731795051445 5.553888141183353 1.6030721833013164 0.3628376459321563 1.0 0.0149620345130709 0.0039499040991049 5.6497138129392335e-05 5.369696142035333e-05 +Mitochondrial respiratory chain complex assembly 15 28 2.656408114790152 0.0078977970452416 14.427184466019416 38.300970873786405 1.6683402305651691 0.229838901803248 5.648441561419256 5.588363345618 1.6629328950455762 0.3088219725228932 1.0 0.3561784256622231 0.0018751862862679 0.0015514010815503 0.0003832480042546 +Organic anion transport 15 34 2.649877175435206 0.008052103794057 18.575242718446603 46.57281553398058 1.6158560948583975 0.2692356013040078 9.46386426798458 5.9518324529926545 1.7470285445738305 0.3371920110610632 1.0 1.0 0.7570799902201406 0.1351139466185282 0.0038434544843807 +Carbohydrate derivative transport 9 14 2.646211266794224 0.0081398961489591 7.924757281553398 17.024271844660195 1.3665639952580566 0.1869571280171947 4.210097511648942 2.624454303682939 1.5541767319140831 0.2467993156006303 1.0 0.1991580424676108 0.3622612502953293 0.0244406528674846 5.116743504388379e-05 +Ceramide metabolic process 6 14 2.638433341366648 0.0083290073246569 8.191747572815533 19.060679611650485 1.0632949889077032 0.1865092544415649 3.2982239784478966 2.5917545738626013 1.8901201919357584 0.2494992632187684 1.0 0.2406936845278361 0.0177960185678587 0.0024061053673092 0.0187445781233054 +Intracellular protein transmembrane transport 5 18 2.6113130164735665 0.0090195296181936 7.233009708737864 21.9004854368932 1.450039081018812 0.2247265328975946 3.8281123729210935 2.4627910122818513 1.3220665029303609 0.2876555154826584 1.0 0.0196403757049561 0.0009182879541791 0.0043649502990921 0.0052617874550274 +Organic acid transport 12 33 2.605213583456876 0.0091817004050165 16.199029126213592 46.1626213592233 1.6912598339530378 0.23494744574913 7.685833584742487 5.405881453891157 1.4084922190667013 0.315570201131532 1.0 0.4854356723902606 0.3851788136583873 0.0058885527356408 0.0023758316122762 +Protein transmembrane import into intracellular organelle 3 12 2.5900577031880743 0.0095959845425974 4.951456310679611 13.45631067961165 1.503963012554726 0.1758225015375162 2.735521961789203 1.4944992929031071 1.2360761671845495 0.245991671368161 1.0 0.0090330503435184 0.0029806631250197 0.0055331858379351 0.0132180269039013 +Regulation of hormone levels 14 45 2.575827937461045 0.0100000395066282 15.682038834951456 62.25485436893204 0.7754141622249116 0.4638741971732045 6.630568201753413 6.49574922456989 1.111399769110166 0.3798141702267368 1.0 0.2801791252263636 0.0598707219111325 0.016104158939004 0.0584973832054215 +Membrane lipid catabolic process 5 11 2.566934034586998 0.0102602129001125 5.854368932038835 11.361650485436892 0.500872843713425 0.1363587272813367 1.9603237645724247 0.9867004907377388 2.113024793917032 0.2289617793743788 1.0 0.0919337377678228 0.0008978593047678 5.415752101895563e-06 0.0002599861644489 +Sphingolipid biosynthetic process 3 11 2.5445548224002645 0.0109417134559817 6.543689320388349 16.33252427184466 1.3108583596388097 0.2293036031089034 3.2058099533310203 2.4273143169149307 1.5209865792019848 0.2861850290041513 1.0 0.0325345581006573 0.0195000915431133 0.053649406266927 0.3148491478678726 +Inorganic anion transport 9 15 2.5432330544859507 0.0109831944899152 9.900485436893204 25.351941747572816 1.3590123122148194 0.2025490755989976 4.608697956226863 4.352203003870329 1.5972877171217004 0.2769639658120273 1.0 0.0432831882721129 0.0044625009891105 0.0013192316861744 0.0004094755795658 +Membrane lipid biosynthetic process 4 16 2.5424770133697367 0.0110069840938784 8.866504854368932 23.050970873786408 1.3229385051208649 0.2431293012321725 4.229937732502716 3.4850337476777224 1.635527795490498 0.2996124846932806 1.0 0.0589240460435226 0.0082058667706489 0.0478393395788808 0.3591751057655991 +Steroid biosynthetic process 6 33 2.538883497403543 0.0111206848308436 11.728155339805824 44.80825242718446 0.9874364787035632 0.3935759881445143 5.016369659264937 4.35272817633461 1.2862817592315925 0.3680333006848349 1.0 0.078986772223975 0.0003487389907513 0.008907043045769 0.0178357245909755 +Oxidative phosphorylation 11 47 2.5300314700681628 0.0114052296493001 18.140776699029125 60.61893203883495 0.8137621380364766 0.3661293054253088 7.750013302753429 5.582386553809936 1.7413544544034578 0.3762713520958283 1.0 0.1115719060554689 0.0284415048722066 2.872931465890857e-05 0.0001743407477391 +Cellular respiration 16 84 2.527219072472472 0.0114969762263783 27.975728155339805 102.1019417475728 0.3887198796668061 0.4496840882999475 12.70690482749566 7.191843824002275 1.6294784865611704 0.3894421445164553 1.0 0.002043613805171 0.0023833705705514 3.041491313067087e-06 0.0001050209211645 +Blood vessel endothelial cell migration 4 19 2.507405643174154 0.0121621048364946 4.536407766990291 22.449029126213592 0.7681724367497832 0.3963490094539818 2.4704338498615206 2.406468634828595 1.0319905271466427 0.3120666413936225 1.0 0.0045553852335938 0.0304335118961749 0.0266777247012389 0.2457491918799613 +Iron ion homeostasis 5 15 2.498682305023934 0.0124656007156171 4.468446601941747 17.140776699029125 1.0306963602610326 0.26770320823289 2.1032740346004313 1.762496954108992 1.1437451534606062 0.2692749918411525 0.0099793916623619 0.0248381956323572 0.0876106046642714 0.0013464853239791 0.034492515261231 +Transition metal ion homeostasis 6 19 2.471313106842631 0.0134617895853623 6.640776699029126 24.57281553398058 0.9239194315613378 0.3015424973151205 2.934079531592402 2.8081087224394015 1.2471169312381896 0.2974369333820005 0.0156316289009573 0.0564048148733258 0.1821593613874541 0.0031061282245647 0.0377489247785575 +Ion transmembrane transport 41 121 2.4668754447354733 0.0136297759010901 47.09466019417476 154.11893203883494 1.555073205784263 0.3634279635891347 19.61122797656 15.97124025754773 1.9676287128633565 0.411597796705808 1.0 0.3775589691339882 0.0331515832532143 0.0015642901479476 7.881557728869421e-05 +Cellular monovalent inorganic cation homeostasis 5 17 2.46659346005271 0.0136405126462768 8.191747572815533 25.12378640776699 1.1978511848260835 0.2636491484517694 3.558748260132903 2.9783551257949803 1.4212259473978417 0.3021468238591936 1.0 0.2552681350600493 0.0212914346042941 0.0033989983353886 0.0262857775313941 +Vacuole organization 12 36 2.4586072536175605 0.0139477107977719 14.220873786407768 51.74514563106796 0.8524122478550634 0.3147425083910056 5.370022076358251 7.439112114793103 1.7567175511320523 0.3563110134355993 1.0 0.5287686777468734 0.1908142682494453 0.1719391325579152 0.0697898046379425 +Nucleotide transport 8 12 2.451648175395153 0.0142203624688599 6.189320388349515 13.405339805825244 1.3859091987706234 0.2148450774807873 3.399469193898354 2.266957807297256 1.34942986946681 0.2785977875693559 1.0 0.1178616319260966 0.0260710687649276 0.0032545859437725 1.907673106738708e-06 +Carboxylic acid transport 8 25 2.439568866538996 0.0147047996017923 12.351941747572816 33.69417475728155 1.517249458545343 0.2522623764771551 6.23371050940395 4.11174791553619 1.419876490432768 0.3135855212793009 1.0 1.0 0.6429167118783385 0.0413515024466966 0.0292206700466903 +Glycosphingolipid metabolic process 4 7 2.4356562479182973 0.0148648032254461 4.764563106796117 9.184466019417476 0.4485135251287195 0.1553285492394019 1.7516723087054535 1.7320372023153958 1.93068386398988 0.2217231968869004 1.0 0.1471951297158956 0.0405463165390607 0.0010720436073174 0.0195746287107578 +Ceramide catabolic process 4 7 2.4170050064322126 0.0156488018886364 3.8592233009708736 6.531553398058253 0.1286784152295923 0.1423502941444668 1.429436503356119 0.7012295128365029 2.0219843992394857 0.2259194528389771 1.0 1.0 0.0057815105752346 5.41373461507268e-06 0.0001501374850564 +Protein import into mitochondrial matrix 2 9 2.4070682147905296 0.0160811658075357 3.3276699029126213 9.03883495145631 1.4677455160780188 0.1396272549365287 1.9612536628062327 0.7162785445212654 1.2893924319512868 0.2212161399323651 1.0 0.0022827689145391 0.0090253131212995 0.0050923434600555 0.0047081007231922 +Regulation of endothelial cell migration 4 22 2.403665943689168 0.0162315982387348 5.495145631067961 27.978155339805824 0.5955926179251096 0.4502618340992453 2.841693008322481 3.167187428757454 1.0132828172462562 0.3207559953771818 1.0 0.0131788445501069 0.078476478485312 0.1033455447275472 0.3749175416707638 +Polyol biosynthetic process 3 8 2.3745241538527586 0.0175715865141041 2.9635922330097086 12.021844660194176 0.4599160783460149 0.4354618009678472 1.610383391828647 1.311638897421378 1.0038412166581965 0.2944331431932714 1.0 1.0 0.045127039841821 0.0096252938706505 0.0853276090719553 +Phospholipid transport 4 9 2.370340238909479 0.0177717225743592 4.038834951456311 13.844660194174756 0.8595089147672731 0.22382450694892 1.931709490395295 2.5542930986961077 1.4491821424024287 0.2459407475876757 1.0 0.2183067054048652 0.0876106046642714 0.0341229578056568 0.0968560278048493 +Negative regulation of secretion 6 13 2.36134273881879 0.0182088930524222 4.148058252427185 18.021844660194176 0.8973427539161298 0.3984823243406039 2.1406652437798495 2.8560969523306214 0.8942114095598058 0.3123655158346225 1.0 0.2695684389372801 0.0251363642152908 0.0200399882581909 0.0122020548708259 +Negative regulation of response to external stimulus 6 35 2.357152194616336 0.0184156974835312 9.381067961165048 47.019417475728154 0.8063071074275461 0.4700507256615295 4.127569023520378 6.3589713134688575 0.9364755672970396 0.3491987458588393 1.0 0.048700724445905 0.2311252530092082 0.1198631926711832 0.1210626462601338 +Regulation of phospholipase activity 4 8 2.3501408241954698 0.0187663095737773 2.3033980582524274 8.655339805825243 0.4716760674233964 0.3608985608449799 1.8831620038679 1.0692732451911044 1.1444196149370027 0.2826906840950133 1.0 0.1305522111527444 0.2467424796819782 0.154226710893935 0.0114560670370992 +Monovalent inorganic cation homeostasis 5 18 2.3477267990645205 0.0188883699159778 9.014563106796116 27.87378640776699 1.1567920478867002 0.2845186374336156 4.051822262152646 3.607380814764068 1.4117439861533438 0.3149022278800241 1.0 0.297366720714231 0.0338721796728873 0.0082077294132096 0.023341028568652 +Regulation of cellular ph 5 12 2.341902896040096 0.0191857058552933 6.885922330097087 20.844660194174757 1.215766922704761 0.2375185297794358 2.9319293283093293 2.765976649626597 1.4143296516981956 0.2875299337708636 1.0 0.2107016729382093 0.0118453859760714 0.0010882828125207 0.0289999376209375 +Regulation of ph 5 12 2.341902896040096 0.0191857058552933 6.890776699029126 20.859223300970875 1.2151699598837196 0.2373503364294603 2.930458126920059 2.7746402510870145 1.4154672965603718 0.2873526492076106 1.0 0.2220822570468345 0.0139156518076104 0.0014919193154812 0.0374739153185052 +Regulation of lipase activity 5 11 2.340927725067814 0.0192358904854941 3.262135922330097 11.20873786407767 0.5080857493577803 0.3640362286084045 2.107366483573331 1.390020380944142 1.1722840995258883 0.3007278087276755 1.0 0.1755724648168266 0.3236452024265956 0.2511786735203468 0.0114133363368107 +Positive regulation of epithelial cell migration 6 21 2.3273412226466954 0.0199471114050877 5.648058252427185 28.92718446601942 0.4281502818361513 0.5649469814193326 3.094768701695654 4.042197186207753 0.7930122889691048 0.3121124271075066 1.0 0.0818055658937606 0.2498296739424394 0.0909960920222553 0.1981327083689323 +Regulation of oxidative phosphorylation 1 7 2.32045393102211 0.0203163343209742 2.0266990291262137 8.405339805825243 0.5212596953879275 0.3786062166885635 1.6210885042287937 1.4888813260225289 1.142050430358633 0.295953719868097 1.0 0.0026008925831016 0.0102498345034834 0.0557098434243155 0.1778574078192432 +Liposaccharide metabolic process 5 12 2.319229646137469 0.0203825878110497 7.393203883495145 16.839805825242717 0.7162233803449398 0.1804705798886219 2.8837934205508033 2.921890590438037 1.8930166841377585 0.2403675114219934 1.0 0.2443632781182481 0.0186371594327644 0.0026306375243077 0.0587745096161565 +Peptidyl proline modification 7 30 2.3123136305942493 0.0207604060746733 7.95873786407767 32.38106796116505 0.6521103584457676 0.5266525958057561 3.2591538539789924 3.194797169860135 0.931894104733149 0.3508680261875629 1.0 0.0230489069918226 0.0118453859760714 0.0001580597168237 0.000467430048284 +Sterol homeostasis 5 9 2.2980189488755616 0.0215607106723185 3.2597087378640777 11.594660194174756 0.7425754872590924 0.2773502445350785 1.6018884221780605 1.6170423171351411 1.3033948892752858 0.2615762483252933 1.0 0.0142466262053111 0.0523352985295366 0.0128293519549119 0.0088977066355322 +Diol biosynthetic process 3 5 2.2856268153593837 0.0222761000305087 2.5315533980582523 7.747572815533981 0.934609081792458 0.2730932800244148 1.324333323602112 0.9054146354978068 1.183401939154622 0.2688651038177358 1.0 1.0 0.0067896670197663 0.0001991597833083 0.0026623648375823 +Diol metabolic process 3 5 2.2856268153593837 0.0222761000305087 2.5315533980582523 7.747572815533981 0.934609081792458 0.2730932800244148 1.324333323602112 0.9054146354978068 1.183401939154622 0.2688651038177358 1.0 1.0 0.0102498345034834 0.0004788146962384 0.0060423314672148 +Ph reduction 4 8 2.265579991541642 0.0234771112850182 4.422330097087379 12.509708737864075 1.1966830084586066 0.1930048880851129 1.91475781321527 1.7851607614701208 1.4167744165903868 0.2497649393583847 1.0 0.1263420182810564 0.0024390672757694 0.0004897389809093 0.0098610483774859 +Respiratory electron transport chain 9 38 2.246151908989729 0.02469427938745 15.4126213592233 50.33495145631068 0.497076868891423 0.4388579749555677 7.129498131980449 4.223655269147207 1.4894225458303931 0.3736358875877055 1.0 0.3716405295483306 0.2390296323992287 0.0001017171643149 0.0166863175624847 +Regulation of epithelial cell migration 6 32 2.239285394363578 0.0251373525960223 7.686893203883495 41.150485436893206 0.4683916151372655 0.5421818797250589 4.038230298045284 4.831799475569947 0.8737130528383311 0.3302003727650362 1.0 0.0311325232191064 0.1619396552785848 0.1319695637736293 0.2497156582251711 +Aerobic respiration 13 72 2.232422855444294 0.0255870286384061 23.075242718446603 86.43446601941747 0.4685851027775424 0.4381258038241513 10.546552774557412 6.275478278783705 1.570513830163352 0.3792860784147517 1.0 0.0069963732250582 0.0044497862190796 2.9295115710827377e-05 0.0002180288234627 +Vacuolar acidification 4 6 2.231369475420447 0.0256566650738527 3.4757281553398056 8.922330097087379 1.27407749822917 0.1611429668415415 1.4148632661931722 1.303016071016461 1.4195929612668792 0.2212670077717619 1.0 0.083126337411673 0.0006517968090871 5.200397996359343e-05 0.0012775061284849 +Nucleotide transmembrane transport 6 9 2.2258005320421703 0.0260275451738709 4.029126213592233 9.24271844660194 1.3657020532080593 0.1972377481261837 2.230443861436908 1.484326001257553 1.1744026177454787 0.2553979780962895 1.0 0.0742352733278267 0.0102498345034834 0.0004788146962384 4.444471381104669e-06 +Oligosaccharide metabolic process 3 6 2.2190602665308083 0.0264826247338496 3.0606796116504853 6.179611650485437 -0.0148577354153068 0.2267163537664357 1.4017006052191363 1.1242135739548185 1.7186048285621385 0.2671195008920222 1.0 1.0 0.2012104780589677 0.0020400745925255 0.0225482630910853 +Sterol biosynthetic process 4 18 2.2068062094754857 0.0273276010691749 7.281553398058253 24.52912621359223 1.190088798384403 0.3136799329736269 3.292879861326439 2.61838648411319 1.1232845583768152 0.3105481837594456 1.0 0.2030241760545403 0.0010831329822185 0.0052710570752827 0.0067157825595968 +Negative regulation of epithelial cell apoptotic process 0 6 2.181427723633449 0.029151794927819 1.6237864077669903 6.706310679611651 0.225100363063322 0.5337462830315725 1.406198909064463 1.464352794705454 0.8369835800966049 0.2591125404708713 1.0 0.1135912525516411 0.2166826538338764 0.4573561220916043 0.7085155867377892 +Glycoside metabolic process 3 8 2.1704043064608403 0.0299762308540401 3.283980582524272 8.611650485436893 0.5062828222010527 0.3204164092287125 1.4990079825210394 0.6824144700308834 1.298018080705215 0.2868097664691992 1.0 1.0 0.1362380906066266 0.000366006536683 0.0047081007231922 +Modified amino acid transport 3 5 2.143523360546897 0.0320710973461288 2.029126213592233 5.587378640776699 1.6181581718562612 0.1578136127091599 1.2124460606928238 1.444653995706506 0.7704353439327314 0.2037484924456972 1.0 0.0919337377678228 0.0158256043387446 0.0011814468070448 0.0138168318064428 +Chemical homeostasis 33 133 2.1335366424316 0.0328807290952239 43.762135922330096 177.7597087378641 0.7082111793088889 0.511106347874914 13.668464281922288 17.87763227716401 1.3204137511810292 0.4179418895476048 0.1064646802046236 0.049697097202694 0.1740773688744091 0.0493820297218256 0.0629578730185151 +Energy derivation by oxidation of organic compounds 17 102 2.131348640301669 0.0330604306925486 30.652912621359224 122.18932038834951 0.2541815110246533 0.5071130371174295 12.61138398748304 8.311769788309597 1.4201467433346076 0.3884313364311733 1.0 0.0059885984942463 0.0093039035177462 2.3340469237952927e-05 0.0002648635690959 +Lipid storage 3 12 2.131036836945289 0.033086107551034 4.543689320388349 16.905339805825243 0.2970217553985043 0.3661937485285719 2.202279044729986 2.0116820549871304 1.1851757279860726 0.2726034839593525 1.0 0.2333020504203794 0.0161789595718159 0.0432632841258681 0.1233028492671564 +Glycolipid catabolic process 3 6 2.1286426037627604 0.0332838408522253 3.6310679611650487 6.451456310679611 0.1059933679561382 0.1697430158083476 1.434595381284437 0.7664524352299261 1.9023109688101565 0.2365791262889882 1.0 1.0 0.1105474823156849 0.0001405335592956 0.0019152907278613 +Endothelial cell proliferation 5 12 2.122864083730718 0.0337652429018313 3.737864077669903 17.388349514563107 0.8369436650143091 0.4126693113525184 2.24564806763238 2.518795403681403 0.8441326938580735 0.2996825893791121 1.0 0.0479057539651017 0.1579906452537346 0.0312610879309806 0.1378034958599644 +Response to oxidative stress 22 73 2.112215575399742 0.0346679631847688 18.145631067961165 95.9757281553398 0.5057872201816154 0.5358657948719677 6.785060354870026 9.30128883458378 0.9511882590088212 0.3606217523881886 0.0566504553877448 0.0515614855824522 0.0075474342657837 0.0007344886330701 0.0140399049005922 +Vitamin transmembrane transport 3 6 2.104710532457144 0.0353165131024564 2.9344660194174756 6.094660194174757 1.6910321805591797 0.1136175735100163 1.344920850275403 0.8913122381585616 1.0580472895861666 0.1862049292817703 1.0 0.0697581245313758 0.0090253131212995 0.000366006536683 0.0005047578024907 +Vitamin transport 3 6 2.104710532457144 0.0353165131024564 3.587378640776699 7.597087378640777 1.658661901456128 0.1256251915839625 1.8073839707699664 1.6422194495621811 1.0713624000848283 0.1994200282768667 1.0 0.1093006244161378 0.0224191931510111 0.0024022577840735 0.0049936971639372 +Lipoprotein metabolic process 4 15 2.0955926537988643 0.0361183414523296 5.504854368932039 19.114077669902912 1.0723975558987071 0.2794846862458811 2.648039342123219 3.7213756556771336 1.2556798055308762 0.2951644225033464 1.0 0.0627750690965546 0.049541392930243 0.0543296939149059 0.3881562566414057 +Hormone metabolic process 7 22 2.0819741189782683 0.0373448337895379 8.95631067961165 28.65776699029126 1.130508313948193 0.2963365150575847 3.9674689274001818 2.5345884681715156 1.346801337886388 0.3240077568826507 1.0 0.078986772223975 0.0145653075103282 0.0851257395407892 0.0942978413596304 +Folic acid metabolic process 2 7 2.077262091397928 0.0377773758494772 1.91747572815534 7.140776699029126 1.2977645388348351 0.249592124826322 1.215987926650751 0.8615786924829095 0.8405378716662024 0.2600707347072601 1.0 1.0 0.0078714328443906 0.0041470760753771 0.0270223565022924 +Ceramide biosynthetic process 2 6 2.055937975513289 0.0397884950843951 4.033980582524272 10.24757281553398 1.048715387316577 0.2344614502118888 2.237979905601341 2.0281678881596505 1.4071730245015133 0.2685344998940062 1.0 0.1553991536419083 0.045127039841821 0.051542815486873 0.2357230015553132 +Exonucleolytic catabolism of deadenylated mrna 6 8 2.054774283890188 0.0399008111693981 2.54126213592233 9.24757281553398 0.1824640915196664 0.5478662477472535 2.1294847271416195 1.1134085390345203 0.8697427405429277 0.2885247436984134 1.0 0.0017062060788896 0.0067896670197663 0.0379575415698398 0.0002343739811342 +2 oxoglutarate metabolic process 1 9 2.0511743817906347 0.0402499677606309 3.453883495145631 9.264563106796116 -0.1064110443111423 0.384612626342152 2.2992842841711263 0.7004898101848963 1.2698803823360194 0.3050485324830972 1.0 0.0022827689145391 0.0090253131212995 0.0495157384890535 0.1604664600419098 +Positive regulation of endothelial cell migration 4 15 2.046621537078782 0.0406952585434423 4.131067961165049 20.038834951456312 0.4292798614901122 0.501424383087746 2.512552144122521 2.5795022101891343 0.8904747448054084 0.2977037285288963 1.0 0.0444222413024675 0.1478341052968547 0.0884683246757208 0.2457491918799613 +Dicarboxylic acid transport 6 13 2.0446125814428737 0.0408930681308461 5.718446601941747 16.097087378640776 1.1205667041867788 0.2998586575349944 3.584398436287638 2.226340822602054 1.0973546365412417 0.2986830136605488 1.0 1.0 0.3367676981326228 0.2691814013824262 0.0143931802338971 +Regulation of protein secretion 9 27 2.044531017754608 0.0409011163906334 9.725728155339803 40.37135922330097 0.4397575592309385 0.6317801864713505 4.052449601261029 5.3326667855507255 0.7141892385666174 0.3295535821820476 1.0 0.4517357114503159 0.1194557751624266 0.1802028808367961 0.3868563782749007 +Regulation of phospholipid metabolic process 1 8 2.0370484781922955 0.0416451841906124 1.9296116504854368 9.635922330097088 0.662129324721178 0.4086518494099616 1.5555715225620497 1.3998858739150144 0.9005081411083155 0.2701938615678836 1.0 0.0058373227860703 0.0224191931510111 0.1131762501747812 0.1058637057364033 +Response to food 1 5 2.032926883565408 0.0420599105189372 1.720873786407767 5.783980582524272 1.3281223897944048 0.1823213242558801 0.9790282548915298 0.8299231919143666 1.0823564620426191 0.211054619984942 1.0 0.0607401038440192 0.1191939669275513 0.0379575415698398 0.1267898121563239 +Pigment metabolic process 1 17 2.0297698611268817 0.0423799378612426 6.730582524271845 27.429611650485437 0.7330558837492486 0.3938325994367372 3.1680652652278396 2.973572406869117 1.1788232115476622 0.3357800616079686 0.0107599726091932 0.0285808600856777 0.0995728547031488 0.1467586347483675 0.4967049557976621 +Response to oxygen levels 11 50 2.026632192975734 0.0427000416866292 12.5 62.737864077669904 0.8042614609462893 0.4659445696529398 5.042296826006319 7.106965221607376 0.959407798819026 0.3671515409983293 0.0375014983415002 0.2372519605391938 0.1181156312231897 0.0442169217875986 0.2182871238991032 +Intestinal absorption 1 8 2.01052049972434 0.0443761287815405 1.7354368932038835 8.587378640776699 0.5171971357504386 0.4141116500991276 1.4895775622567284 1.230532256111229 1.0157231952918233 0.2848944302917708 1.0 0.0697581245313758 0.1362380906066266 0.0495157384890535 0.1604664600419098 +Positive regulation of endocytosis 4 14 2.0037799302524184 0.0450936396390533 4.560679611650485 19.640776699029125 0.3893750024867851 0.549188937881148 2.507020729109805 3.151065065533248 0.827344309517849 0.2971633472740571 1.0 0.2588687133858448 0.4548903476361624 0.4433113407838488 0.1764937042945174 +Lipid metabolic process 45 200 2.0036136275411014 0.0451114649239612 70.49514563106796 273.7014563106796 0.4234492243219149 0.5257500979287635 24.98470358696109 28.74867152381156 1.6795947056521872 0.4126649977131845 1.0 0.0002481450571086 1.1437136520384283e-06 1.0471673906877366e-08 4.414945816331493e-07 +Glycoside catabolic process 3 5 1.9986280714552644 0.045648610774333 2.995145631067961 5.604368932038835 0.914408298188202 0.1915126053981477 1.4021397407455505 0.554137429771367 1.5051386650706404 0.245673751384095 1.0 1.0 0.075113296023457 2.1451255431067108e-05 0.0003159986655096 +Antigen processing and presentation 3 20 1.9984723585292508 0.0456654737640613 6.201456310679611 22.17718446601942 0.8231471183465873 0.4220086818460768 2.970845032857872 3.056135613532617 0.9682333159777928 0.3245513416930483 1.0 0.2406936845278361 0.1057169178564165 0.0483010618227088 0.1376570310950861 +Regulation of atp metabolic process 4 21 1.9975783832909624 0.0457623887472988 5.475728155339806 26.274271844660195 0.334640781503248 0.5621665759070464 3.158728576082886 2.9845912055027837 0.8610357625710494 0.3157017370833172 1.0 0.0335548880884004 0.1151189883762866 0.0145897333531984 0.1604828788989237 +Isocitrate metabolic process 1 6 1.991274569781428 0.0464507096384831 2.3276699029126213 5.495145631067961 -0.2061858290398174 0.3041702034210444 1.4604532504880654 0.4999764345469411 1.4464876184642763 0.300957520728341 1.0 0.0003352480301583 0.0013648737359616 0.0081566962170519 0.0303937179684932 +Amide transport 9 29 1.9855134090384423 0.0470873797575055 9.512135922330096 37.99757281553398 0.8625203235532012 0.4243895840783888 3.9342099663331425 4.541875701235624 0.963016155404646 0.3369249994514658 1.0 1.0 0.3851788136583873 0.0178098913666631 0.123160583704977 +Lipid biosynthetic process 16 97 1.9826828302920592 0.0474028686348333 38.012135922330096 141.7257281553398 0.5620793375816577 0.4367444072022249 15.729119254593195 17.314902336322657 1.553306672697969 0.3832082090559359 1.0 0.0155375157211394 0.0026870897089852 0.0145880615629743 0.1217297319434546 +Sulfur compound transport 5 8 1.9784670280113812 0.0478760446661414 3.504854368932039 9.429611650485436 1.339223354728307 0.2167503093092372 2.046184165461596 2.1092484385198076 1.0728301411615704 0.2604171804663498 1.0 1.0 1.0 0.1887844423268079 0.0043697957441019 +Regulation of epithelial cell apoptotic process 0 8 1.9784313495048196 0.0478800660516682 2.344660194174758 10.32766990291262 0.1848086455249497 0.5810956584673603 1.8148913768528188 2.0859938395889146 0.7613408224721018 0.2673333584754002 1.0 0.1795501084992132 0.3302382631712943 0.6333450487016228 0.8677910749665385 +Peptidyl proline hydroxylation 3 8 1.964963299905784 0.049418485388869 2.9393203883495147 7.366504854368932 0.8317722887875127 0.3653030215718857 1.5036226559632782 0.8268224457358132 1.022007383809078 0.3112189596123257 1.0 1.0 0.1105474823156849 0.0025975272437437 0.0019152907278613 +Peptide catabolic process 2 10 1.9618527858085235 0.0497796260491172 3.871359223300971 10.351941747572816 1.5413280472635258 0.1625248535751528 1.454973091229298 0.9501768442987896 1.1353491763523988 0.2229381591694359 1.0 0.0875404472016038 0.0007685743700876 0.0101015401572799 0.0016660348526245 diff --git a/msigdb_gobp/metrics.json b/msigdb_gobp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..c125dbbb9d6d9ddefd2780b17dd3d77342e1838b --- /dev/null +++ b/msigdb_gobp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2454, + "annotations_size": 6160, + "title": "Average number of proteins per term", + "value": 15.79512987012987 +} \ No newline at end of file diff --git a/msigdb_gobp/paths.json b/msigdb_gobp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..622f9d533899f424367522afc177d4950706da59 --- /dev/null +++ b/msigdb_gobp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gobp/fragment/C340/C340_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gobp/result.tsv b/msigdb_gobp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c4bc5a336d88f78f70ed8ac1a7405918b8db674d --- /dev/null +++ b/msigdb_gobp/result.tsv @@ -0,0 +1,1546 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Lipid localization 0.6148622534827887 3.603086905498626 0.0003144603327556 0.8559190926175203 0.1624579319174096 54 Q14108,P17900,P61916,O43772,P04062,Q14849,P08183,Q8WTV0,P23786,P31751,P04083,Q9UHB6,Q9H6V9,P35790,Q9BQE5,O15439,Q99720,Q00169 18 +Secondary alcohol metabolic process 0.7478547214420208 3.5964659959445826 0.0003225697278377 0.8629418609025975 0.1624579319174096 33 P48449,P05067,Q9UBM7,O75874,Q14849,Q8WTV0,P04062,Q9UHB6,Q16850,Q9BQE5,P48735,Q15392,Q14739 13 +Alcohol metabolic process 0.604867618450552 3.5954332202375885 0.0003238521975779 0.8640207037100804 0.1624579319174096 62 P61916,P48449,P05067,O94788,Q9UBM7,O75874,Q14849,Q8WTV0,P04062,P35270,P00374,Q9UHB6,Q16850,Q9BQE5,P48735,Q13510,Q15392,Q14739 18 +Anion transport 0.6258408072869222 3.3509492043778684 0.000805350735054 0.993007794551738 0.1624579319174096 48 Q9Y619,Q8TB61,P08183,Q6NUK1,P21796,O43808,O15439,P45880,Q02978,Q9H2D1,Q9UHG3,P41440,Q15041,Q9H2J7,Q9HC21,P04083,Q9Y277,P55011,Q9C0H2,Q9UBX3,O43681 21 +Sphingolipid metabolic process 0.7861932555023231 3.3077140453461333 0.0009406080047351 0.9969629603242603 0.1624579319174096 22 P17900,Q06136,P06280,Q96G23,P04062,P50897,P16278,Q13510 8 +Mitochondrial transport 0.558988935093334 3.288064671465921 0.0010087866340511 0.9980053010429412 0.1624579319174096 71 Q9UJS0,O60830,Q99595,Q6NUK1,Q8N4H5,Q10713,Q5JRX3,Q9UJZ1,Q9NS69,P45880,O43772,O75947,Q14849,P23786,O43464,O14737,Q15785,O14925,P55786,O75964,P56134,O95831,Q15388,P12235,Q96EK5,O75431,Q9UII2,O95140,P24539,Q9UBX3,Q99797 31 +Steroid metabolic process 0.5858337007565774 3.2374109051507594 0.0012061959671625 0.999409565518772 0.1624579319174096 52 P48449,P05067,Q9UBM7,P04062,Q14849,Q8WTV0,Q9UHB6,Q16850,Q9BQE5,Q13510,Q15392,Q14739 12 +Transmembrane transport 0.5243996480836552 3.231650108253862 0.0012307766043382 0.9994926215243228 0.1624579319174096 164 Q9Y619,O60830,Q8TB61,Q99523,Q9HD20,Q99595,Q8WTV0,P08183,Q6NUK1,P21796,O15439,Q9NS69,P45880,Q8IXU6,P61421,O43772,P05067,P31930,Q9BSK2,P23786,Q9H2D1,Q9UHG3,Q6NT16,P41440,O14925,O75964,O75844,Q8N4V1,Q9H2J7,Q15629,P00403,P20674,O95831,Q9C0H2,Q70HW3,Q9UDW1,P30626,P04062,Q9UBX3,Q99797 40 +Organic hydroxy compound metabolic process 0.5330239817257122 3.226033563361287 0.0012551863679861 0.9995635359776234 0.1624579319174096 84 Q8WTV0,Q9BQE5,P48735,Q15392,Q14739,P05067,O75874,Q14849,Q16850,Q13510,P61916,P48449,P00374,Q9UBM7,O94788,P04062,P35270,Q9UHB6,Q14914 19 +Membrane lipid metabolic process 0.7175266159973177 3.194398382684118 0.0014012260567739 0.9998226890421832 0.1624579319174096 28 P17900,Q06136,P06280,Q96G23,P04062,P50897,Q8NBX0,P16278,Q13510 9 +Mitochondrial transmembrane transport 0.6247188430386641 3.048103269603581 0.0023029077203593 0.9999993207462726 0.1624579319174096 41 Q9Y619,O60830,O43772,Q9BSK2,O75964,Q99595,P23786,P21796,O95831,Q9H2D1 10 +Organophosphate ester transport 0.7492355676391863 3.045081383725342 0.0023261735506834 0.9999994116366276 0.1624579319174096 21 Q14108,P41440,P61916,Q8TB61,Q9BSK2,P08183,Q8WTV0,Q9H2D1,O15439,Q00169 10 +Regulation of blood pressure 0.8180172739540353 3.04070418658738 0.002360255941944 0.9999995232920214 0.1624579319174096 15 P42785,Q9HB40,Q9UIQ6,P09601 4 +Sterol metabolic process 0.6868998812176008 3.0387340880607465 0.0023757445160401 0.999999566770324 0.1624579319174096 29 P48449,P05067,Q9UBM7,P04062,Q14849,Q8WTV0,Q9UHB6,Q16850,Q9BQE5,Q15392,Q14739 11 +Protein targeting 0.5026133333286019 3.0173096873165264 0.0025502912230657 0.9999998525623308 0.1624579319174096 90 O60830,Q99523,Q99595,P46379,Q8N4H5,P31751,Q5JRX3,Q9NS69,Q5W0Z9,O43464,O14737,O60725,Q14108,O14925,P55786,Q15041,Q15629,O95831,P43307,Q9UII2,O43681,Q99797 22 +Anion transmembrane transport 0.6624202417441524 2.9965715087038713 0.0027303419310578 0.9999999515100296 0.1624579319174096 32 Q9Y619,P45880,P41440,Q8TB61,P55011,Q15041,P08183,Q9HC21,Q02978,P21796,Q9Y277,O43808,Q9H2D1,O15439,Q9UHG3,P12235,Q9UBX3 17 +Alcohol biosynthetic process 0.6900991829871675 2.9268310744997397 0.0034243481986595 0.9999999993343014 0.1624579319174096 25 P48449,P04062,P35270,P00374,Q16850,Q13510,Q9UBM7,Q14739 8 +Circulatory system process 0.5302562540795668 2.892299832947769 0.003824327857739 0.9999999999438516 0.1624579319174096 58 Q9NZ08,Q9HB40,P41440,P42785,Q9UIQ6,O75844,P08183,P09601,O15439,P10253 10 +Organic acid transmembrane transport 0.7102056852786338 2.874469494041494 0.0040470686410143 0.999999999985839 0.1624579319174096 22 Q9Y619,P41440,O43772,Q9H2J7,P23786,P08183,Q02978,P31751,Q9H2D1,Q9UBX3 10 +Mitochondrion organization 0.4884119566681107 2.8531667774189833 0.0043285897794296 0.999999999997518 0.1624579319174096 153 O60830,Q99595,Q9Y4P1,Q8N4H5,P14406,P21796,Q9H061,O75880,Q5JRX3,Q9UJZ1,Q9NS69,Q9Y375,P45880,Q13501,O75306,Q9NUQ9,Q9BSK2,O43464,O14737,Q99536,P11233,Q15785,Q13505,Q8IWA4,Q9BWH2,O14925,P55786,Q9NX63,O75153,Q69YU5,O95831,O43676,Q9UH62,Q6DKK2,Q9UII2,O75431,Q00059,O75832,O95140,Q9UG56,P04062,Q5XKP0,Q9P032,Q8N183,Q99797 45 +Organic hydroxy compound biosynthetic process 0.6115496204739685 2.8002393750454493 0.0051064724074076 0.99999999999998 0.1624579319174096 36 P48449,P04062,P35270,P00374,Q16850,Q13510,Q9UBM7,Q14739 8 +Protein targeting to mitochondrion 0.5953196907635991 2.794511688508691 0.0051978161724131 0.9999999999999886 0.1624579319174096 40 O60830,O14925,P55786,Q99595,O14737,Q8N4H5,O95831,Q5JRX3,Q9UII2,Q9NS69,Q99797 11 +Lytic vacuole organization 0.7277014320996268 2.7782705440543833 0.0054649095541432 0.9999999999999978 0.1624579319174096 18 Q14108,P04062,P11117,P50897,O75503 5 +Protein transmembrane transport 0.6863068937295467 2.6822943524690857 0.0073119091885829 1.0 0.170950836682285 21 O60830,O14925,Q99595,Q15629,O95831,Q9NS69 6 +Protein localization to mitochondrion 0.5421400474457493 2.666646192419419 0.0076612277963896 1.0 0.1746552726728183 48 O60830,O14925,P55786,Q99595,O14737,Q8N4H5,P11233,O95831,Q5JRX3,Q9UII2,Q9NS69,Q99797 12 +Mitochondrial respiratory chain complex assembly 0.6332579981382197 2.656408114790152 0.0078977970452416 1.0 0.1746552726728183 28 Q8IUX1,O75306,Q8N183,Q9BSK2,Q16795,Q9H061,Q9Y2R0,O75880,Q69YU5,O95831,O43676,Q9P032,Q00059,Q6DKK2,Q9Y375 15 +Organic anion transport 0.6001810264674218 2.649877175435206 0.008052103794057 1.0 0.1746552726728183 34 Q9Y619,P41440,Q8TB61,P55011,Q15041,Q9H2J7,Q9HC21,Q6NUK1,Q02978,P04083,O43808,Q9H2D1,O15439,P12235,Q9UBX3 15 +Carbohydrate derivative transport 0.7551837446440104 2.6462112667942237 0.0081398961489591 1.0 0.1746552726728183 14 P41440,P61916,Q8TB61,L0R6Q1,Q8WTV0,Q9HC21,Q6NUK1,O43808,O15439 9 +Ceramide metabolic process 0.7536675872370955 2.638433341366648 0.0083290073246569 1.0 0.1746552726728183 14 P17900,P06280,Q96G23,P04062,Q13510,Q99519 6 +Intracellular protein transmembrane transport 0.6979088188565499 2.6113130164735665 0.0090195296181936 1.0 0.1803905923638727 18 O60830,O14925,Q99595,Q15629,O95831 5 +Organic acid transport 0.5996825496509351 2.605213583456876 0.0091817004050165 1.0 0.1824236650175757 33 Q9Y619,P41440,O43772,Q9H2J7,P08183,P23786,Q02978,P31751,P04083,Q9H2D1,O15439,Q9UBX3 12 +Protein transmembrane import into intracellular organelle 0.7837928344248724 2.5900577031880743 0.0095959845425974 1.0 0.1840124476108116 12 O60830,Q99595,O95831 3 +Regulation of hormone levels 0.5458235436880196 2.575827937461045 0.0100000395066282 1.0 0.1840124476108116 45 Q9HB40,O15382,O94788,P30626,O75844,Q14849,P51809,P62820,P04083,Q16836,P40939,Q8NBN7,Q9UBM7,P42892 14 +Membrane lipid catabolic process 0.804362378321826 2.566934034586998 0.0102602129001125 1.0 0.1840124476108116 11 P17900,P06280,P04062,P50897,Q13510 5 +Sphingolipid biosynthetic process 0.7995755280585076 2.5445548224002645 0.0109417134559817 1.0 0.1840124476108116 11 Q13510,Q96G23,Q06136 3 +Inorganic anion transport 0.7216539382886376 2.5432330544859507 0.0109831944899152 1.0 0.1840124476108116 15 P45880,P08183,Q02978,P21796,O15439,Q9UHG3,O43681,Q9UBX3,Q9C0H2 9 +Membrane lipid biosynthetic process 0.7074937904169394 2.5424770133697367 0.0110069840938784 1.0 0.1840124476108116 16 Q8NBX0,Q96G23,Q13510,Q06136 4 +Steroid biosynthetic process 0.5903845833668658 2.538883497403543 0.0111206848308436 1.0 0.1840124476108116 33 P48449,Q14849,Q16850,Q13510,Q9UBM7,Q14739 6 +Oxidative phosphorylation 0.531040142851177 2.5300314700681628 0.0114052296493001 1.0 0.1840124476108116 47 O75306,Q9UDW1,P31930,Q9BSK2,O75964,P00403,P14406,P20674,O43676,O14949,Q9Y375 11 +Cellular respiration 0.4657409215518097 2.527219072472472 0.0114969762263783 1.0 0.1840124476108116 84 O75306,P13804,Q9UDW1,P31930,Q9BSK2,Q16134,O75964,O75874,P04062,P00403,P14406,P20674,O43676,P48735,O14949,Q9Y375 16 +Blood vessel endothelial cell migration 0.6723320527521471 2.507405643174154 0.0121621048364946 1.0 0.1906324829333505 19 P42785,P04792,Q8WTV0,P09601 4 +Iron ion homeostasis 0.7133169829683966 2.498682305023934 0.0124656007156171 1.0 0.1924513794691778 15 P61421,P30519,P09601,Q9Y487,Q15904 5 +Transition metal ion homeostasis 0.6661555618657419 2.471313106842631 0.0134617895853623 1.0 0.2012124185015762 19 P30519,P61421,P05067,P09601,Q9Y487,Q15904 6 +Ion transmembrane transport 0.4417155140817601 2.4668754447354733 0.0136297759010901 1.0 0.2015001388514759 121 Q9Y619,Q8TB61,Q9HD20,P08183,Q13423,P21796,O43808,O15439,Q9UJZ1,P45880,P61421,O43772,P05067,P31930,O75947,Q02978,P78417,Q9H2D1,Q9UHG3,P41440,O75964,P56134,O75844,Q8N4V1,Q9H2J7,Q15041,Q9HC21,P00403,P20674,Q9Y277,Q9UM00,P55011,P12235,Q9C0H2,Q70HW3,Q9UDW1,P30626,P24539,Q06787,Q13642,Q9UBX3 41 +Cellular monovalent inorganic cation homeostasis 0.6796015866046393 2.46659346005271 0.0136405126462768 1.0 0.2015001388514759 17 P50897,Q93050,Q9Y487,O75503,Q15904 5 +Vacuole organization 0.5652149481832918 2.4586072536175605 0.0139477107977719 1.0 0.2055452117566386 36 Q14108,Q9UNZ2,O95140,P04062,P11117,Q9Y4P1,P62820,P50897,P54802,Q6IAA8,O75503,P10253 12 +Nucleotide transport 0.7554348879625273 2.451648175395153 0.0142203624688599 1.0 0.207578248867062 12 P41440,Q8TB61,Q9BSK2,Q9HC21,Q6NUK1,O43808,Q9H2D1,O15439 8 +Carboxylic acid transport 0.613218349512299 2.4395688665389956 0.0147047996017923 1.0 0.2126327829742749 25 Q9Y619,P41440,Q9H2J7,Q02978,P04083,Q9H2D1,O15439,Q9UBX3 8 +Glycosphingolipid metabolic process 0.8892576304548667 2.4356562479182973 0.0148648032254461 1.0 0.2144430629244689 7 P17900,P06280,P04062,P16278 4 +Ceramide catabolic process 0.8847350280084607 2.4170050064322126 0.0156488018886364 1.0 0.2236580501948973 7 P17900,P06280,P04062,Q13510 4 +Protein import into mitochondrial matrix 0.8105357545976348 2.4070682147905296 0.0160811658075357 1.0 0.2272017921431651 9 O60830,Q99595 2 +Regulation of endothelial cell migration 0.6321649688032078 2.403665943689168 0.0162315982387348 1.0 0.2288023916489859 22 P42785,P04792,Q8WTV0,P09601 4 +Polyol biosynthetic process 0.8196415021492831 2.3745241538527586 0.0175715865141041 1.0 0.2432381414087229 8 P00374,Q13510,P04062 3 +Phospholipid transport 0.8023606729786222 2.370340238909479 0.0177717225743592 1.0 0.245456975466486 9 Q14108,P61916,P08183,Q8WTV0 4 +Negative regulation of secretion 0.7128788304638871 2.36134273881879 0.0182088930524222 1.0 0.2465203982481779 13 P04083,Q16836,Q16850,P40939,P09601,P04899 6 +Negative regulation of response to external stimulus 0.5546688061231719 2.357152194616336 0.0184156974835312 1.0 0.2485641661988944 35 O43657,Q9UIV1,P80303,Q9UMX5,Q96G23,P04062 6 +Regulation of phospholipase activity 0.8141048477490305 2.3501408241954698 0.0187663095737773 1.0 0.2507602320487384 8 Q9Y263,P04083,P50897,P18085 4 +Monovalent inorganic cation homeostasis 0.652124158077203 2.3477267990645205 0.0188883699159778 1.0 0.2511739976360448 18 P50897,O75503,Q9Y487,Q93050,Q15904 5 +Regulation of cellular ph 0.7332963352997688 2.3419028960400956 0.0191857058552933 1.0 0.2511739976360448 12 P50897,Q93050,Q9Y487,O75503,Q15904 5 +Regulation of ph 0.7332963352997688 2.3419028960400956 0.0191857058552933 1.0 0.2511739976360448 12 P50897,Q93050,Q9Y487,O75503,Q15904 5 +Regulation of lipase activity 0.7566318573606453 2.340927725067814 0.0192358904854941 1.0 0.2511739976360448 11 Q99523,P18085,Q9Y263,P04083,P50897 5 +Positive regulation of epithelial cell migration 0.6274354204807616 2.3273412226466954 0.0199471114050877 1.0 0.256522351263759 21 P07737,P04792,Q8WTV0,P04083,Q15555,P09601 6 +Regulation of oxidative phosphorylation 0.8614844987624684 2.32045393102211 0.0203163343209742 1.0 0.259644438624899 7 P14406 1 +Liposaccharide metabolic process 0.7287599044541305 2.319229646137469 0.0203825878110497 1.0 0.2599376315805323 12 P17900,P06280,P04062,Q8NBX0,P16278 5 +Peptidyl proline modification 0.5735157767260454 2.3123136305942493 0.0207604060746733 1.0 0.2615216797954759 30 O15460,Q9Y680,O75718,Q08752,Q9BV86,P13674,Q9NWM8 7 +Sterol homeostasis 0.7863703986179009 2.2980189488755616 0.0215607106723185 1.0 0.267770116414279 9 P61916,O15118,Q8WTV0,Q9UHB6,Q5BJF2 5 +Diol biosynthetic process 0.9316106706163754 2.2856268153593833 0.0222761000305087 1.0 0.2725812083072532 5 P00374,Q13510,P04062 3 +Diol metabolic process 0.9316106706163754 2.2856268153593833 0.0222761000305087 1.0 0.2725812083072532 5 P00374,Q13510,P04062 3 +Ph reduction 0.7950305285932012 2.265579991541642 0.0234771112850182 1.0 0.2813599329099467 8 Q93050,Q9Y487,P50897,O75503 4 +Respiratory electron transport chain 0.5314903843953683 2.2461519089897295 0.02469427938745 1.0 0.2932464589668523 38 O75306,P13804,Q9UDW1,Q16134,P04062,P00403,O43676,O14949,Q9Y375 9 +Regulation of epithelial cell migration 0.5541062780876097 2.239285394363578 0.0251373525960223 1.0 0.2949449371266622 32 P07737,P04792,P42785,Q8WTV0,P04083,P09601 6 +Aerobic respiration 0.4512040001216633 2.232422855444294 0.0255870286384061 1.0 0.2968288068033554 72 O75306,Q9UDW1,P31930,Q9BSK2,O75964,O75874,P00403,P14406,P20674,O43676,P48735,O14949,Q9Y375 13 +Vacuolar acidification 0.8943587781441618 2.231369475420447 0.0256566650738527 1.0 0.2970771745393479 6 Q93050,Q9Y487,P50897,O75503 4 +Nucleotide transmembrane transport 0.7705423901032811 2.2258005320421703 0.0260275451738709 1.0 0.2985655088846278 9 P41440,Q8TB61,Q9BSK2,O43808,Q9H2D1,O15439 6 +Oligosaccharide metabolic process 0.8912765798983049 2.2190602665308083 0.0264826247338496 1.0 0.2996949595902456 6 P17900,P06280,P10253 3 +Sterol biosynthetic process 0.62825044740961 2.2068062094754857 0.0273276010691749 1.0 0.3033337246045766 18 Q9UBM7,P48449,Q16850,Q14739 4 +Regulation of phospholipid catabolic process 0.9824632952691672 2.2025343585866315 0.0276275848855778 1.0 0.3049926933605006 2 Q8WTV0 1 +Lysosomal lumen acidification 0.977569331158237 2.182322949782231 0.0290857064017719 1.0 0.3176736727569423 2 P50897 1 +Sphingoid metabolic process 0.9350863620528916 2.171171801153702 0.0299181880977841 1.0 0.3228209476588934 4 Q13510,Q06136 2 +Glycoside metabolic process 0.7737919641955768 2.1704043064608403 0.0299762308540401 1.0 0.3228209476588934 8 P06280,P04062,Q9NUJ1 3 +Modified amino acid transport 0.8957438933297802 2.143523360546897 0.0320710973461288 1.0 0.3365552975334821 5 O15439,O43772,Q9H2D1 3 +Positive regulation of nitric oxide synthase activity 0.9673735725937987 2.14010911256927 0.0323459498297156 1.0 0.3382870134992329 2 Q8WTV0 1 +Chemical homeostasis 0.4209566972051233 2.1335366424316 0.0328807290952239 1.0 0.3391188394581857 133 P30519,Q86YV9,Q9HD20,P42785,Q8WTV0,P50897,Q9Y639,P09601,Q15120,O75880,Q5BJF2,Q15904,Q9UJZ1,P61421,P05067,Q6IAA8,P78417,O75503,P61916,Q9UM00,Q15067,Q93050,P85037,O15118,P04899,P30626,P04062,Q9UHB6,P49366,P13693,Q9Y487,Q13642,Q8N183 33 +Energy derivation by oxidation of organic compounds 0.4055933777279205 2.131348640301669 0.0330604306925486 1.0 0.3391188394581857 102 O75306,P13804,Q9UDW1,P31930,Q9BSK2,Q16134,O75964,O75874,P04062,P00403,P14406,P20674,O43676,P48735,O14949,P10253,Q9Y375 17 +Lipid storage 0.6915857689149998 2.131036836945289 0.033086107551034 1.0 0.3391188394581857 12 P17900,Q9H6V9,Q8WTV0 3 +Glycolipid catabolic process 0.8687660132897059 2.1286426037627604 0.0332838408522253 1.0 0.3405422424441246 6 P17900,P06280,P04062 3 +Endothelial cell proliferation 0.6899903225609673 2.122864083730718 0.0337652429018313 1.0 0.3415334914208229 12 O94788,Q9H2J4,Q8WTV0,P09601,Q9UII2 5 +Response to oxidative stress 0.4389895809465089 2.112215575399742 0.0346679631847688 1.0 0.346033393122415 73 P30519,Q9NR28,P04792,P07237,Q6NUK1,P09601,Q15392,O75306,Q8IXJ6,P05067,Q16134,O75874,O43464,Q15165,Q99720,P28074,O43169,P18074,P00374,P04083,O95831,P04062 22 +Vitamin transmembrane transport 0.8628453901821916 2.104710532457144 0.0353165131024564 1.0 0.346033393122415 6 P04062,Q8WTV0,Q9H2D1 3 +Vitamin transport 0.8628453901821916 2.104710532457144 0.0353165131024564 1.0 0.346033393122415 6 P04062,Q8WTV0,Q9H2D1 3 +Regulation of response to food 0.9571778140293608 2.0977535301127537 0.0359269234749917 1.0 0.3485194466235417 2 P80303 1 +Negative regulation of response to food 0.9571778140293608 2.0977535301127537 0.0359269234749917 1.0 0.3485194466235417 2 P80303 1 +Regulation of appetite 0.9571778140293608 2.0977535301127537 0.0359269234749917 1.0 0.3485194466235417 2 P80303 1 +Lipoprotein metabolic process 0.639937203281788 2.0955926537988643 0.0361183414523296 1.0 0.3487214140318833 15 P50897,P04062,Q9NUJ1,Q9BQE5 4 +Tetrahydrobiopterin metabolic process 0.9555464926590528 2.0909637014414564 0.0365313179772508 1.0 0.3510653958500237 2 P00374 1 +Hormone metabolic process 0.5813765212724349 2.0819741189782683 0.0373448337895379 1.0 0.3560513126811133 22 Q9HB40,O94788,O75844,Q14849,Q8NBN7,Q9UBM7,P42892 7 +Phosphatidylethanolamine metabolic process 0.9530995106035892 2.080772346376567 0.0374547484768443 1.0 0.3560513126811133 2 Q9UG56 1 +Phosphatidylethanolamine biosynthetic process 0.9530995106035892 2.080772346376567 0.0374547484768443 1.0 0.3560513126811133 2 Q9UG56 1 +Folic acid metabolic process 0.8040743696257615 2.077262091397928 0.0377773758494772 1.0 0.3574633413713978 7 P00374,Q9H2D1 2 +Response to l glutamate 0.9070807223831822 2.060955188882992 0.0393073153686502 1.0 0.3652082393226029 4 Q9UQB8 1 +Ceramide biosynthetic process 0.8508268502972908 2.055937975513289 0.0397884950843951 1.0 0.3684448652388768 6 Q13510,Q96G23 2 +Exonucleolytic catabolism of deadenylated mrna 0.7483054398197825 2.054774283890188 0.0399008111693981 1.0 0.3684992455824476 8 Q15024,Q9NQT5,Q9Y2L1,Q9UIV1,Q969T7,Q96C86 6 +2 oxoglutarate metabolic process 0.7328255656410523 2.0511743817906347 0.0402499677606309 1.0 0.3706125581546885 9 P48735 1 +Positive regulation of endothelial cell migration 0.6312629541919375 2.046621537078782 0.0406952585434423 1.0 0.3714448120793702 15 P04083,P04792,Q8WTV0,P09601 4 +Dicarboxylic acid transport 0.6529539968165954 2.0446125814428737 0.0408930681308461 1.0 0.3714739044845724 13 P41440,Q15041,Q02978,Q9H2D1,P55011,Q9UBX3 6 +Regulation of protein secretion 0.5474822675108427 2.0445310177546077 0.0409011163906334 1.0 0.3714739044845724 27 P30626,Q32P28,P49755,Q08752,Q16836,P40939,Q16850,P55011,Q8N183 9 +Glycosylceramide metabolic process 0.944127243066885 2.0433369509568253 0.041019094135855 1.0 0.3714739044845724 2 P04062 1 +Glycosylceramide catabolic process 0.944127243066885 2.0433369509568253 0.041019094135855 1.0 0.3714739044845724 2 P04062 1 +Regulation of phospholipid metabolic process 0.7444281605132075 2.0370484781922955 0.0416451841906124 1.0 0.3739855563444432 8 Q8WTV0 1 +Response to food 0.8681990276067342 2.0329268835654077 0.0420599105189372 1.0 0.3739855563444432 5 P80303 1 +Pigment metabolic process 0.6046818449224023 2.0297698611268817 0.0423799378612426 1.0 0.3739855563444432 17 P30519 1 +Response to oxygen levels 0.4610112863974451 2.026632192975734 0.0427000416866292 1.0 0.3739855563444432 50 P30519,P61421,O75306,P55786,P07237,Q9Y4P3,O95831,P09601,Q15120,Q9Y487,Q15904 11 +Intestinal absorption 0.7386399429134739 2.0105204997243393 0.0443761287815405 1.0 0.3801904774607643 8 Q8WTV0 1 +Positive regulation of endocytosis 0.6347651328312496 2.0037799302524184 0.0450936396390533 1.0 0.3832918950780706 14 P41440,P50897,Q99816,P61978 4 +Lipid metabolic process 0.4344653086927935 2.0036136275411014 0.0451114649239612 1.0 0.3832918950780706 200 Q9HB40,Q06136,Q9H7Z7,O14880,P06280,Q8WTV0,P50897,P16278,P40939,Q9BQE5,Q15120,Q15392,Q14739,O15382,Q8N4Q0,P05067,Q16134,Q96G23,O75874,Q14849,P23786,Q8NBX0,Q8NHP8,Q9H6V9,Q16850,P07099,Q13510,Q99519,P61916,P48449,P13804,O75844,P04083,Q16836,P16219,Q15067,Q9UBM7,P17900,Q9UG56,O94788,P04062,Q9UHB6,Q14914,P35790,O43681 45 +Glycoside catabolic process 0.8597191569974942 1.9986280714552644 0.045648610774333 1.0 0.3855680898684985 5 P06280,P04062,Q9NUJ1 3 +Antigen processing and presentation 0.5815115422247965 1.9984723585292508 0.0456654737640613 1.0 0.3855680898684985 20 Q9NZ08,Q9UIQ6,P04062 3 +Regulation of atp metabolic process 0.5749731918934515 1.9975783832909624 0.0457623887472988 1.0 0.3856310734382504 21 Q9BSK2,P00403,P14406,P05067 4 +Acute inflammatory response 0.8908029761631766 1.99635079701439 0.0458957524751593 1.0 0.3856996388089787 4 P42785 1 +Microglia differentiation 0.9327079934747134 1.9955427885317856 0.045983712239408 1.0 0.3859123533988464 2 P04062 1 +Isocitrate metabolic process 0.8349883392938369 1.991274569781428 0.0464507096384831 1.0 0.3859769004050877 6 P48735 1 +Modulation of excitatory postsynaptic potential 0.8891669159926041 1.989835868056029 0.0466090188680359 1.0 0.3859769004050877 4 Q9UQB8 1 +Response to cisplatin 0.9306688417618224 1.9869909609123269 0.0469233985386656 1.0 0.3869452945089431 2 P09601 1 +Amide transport 0.5319369199315622 1.9855134090384423 0.0470873797575055 1.0 0.3877784215323986 29 P41440,P30626,P08183,P62820,P04083,Q16836,P40939,Q9H2D1,O15439 9 +Lipid biosynthetic process 0.4008535665518397 1.9826828302920592 0.0474028686348333 1.0 0.3898553682117134 97 P48449,Q06136,Q9UG56,Q9H7Z7,O94788,Q96G23,O75874,Q14849,Q8WTV0,P04062,Q8NBX0,P35790,Q16850,Q13510,Q9UBM7,Q14739 16 +Sulfur compound transport 0.7316688750661346 1.9784670280113816 0.0478760446661414 1.0 0.3918124458999699 8 Q8TB61,Q02978,O15439,Q9UBX3,Q70HW3 5 +Peptidyl proline hydroxylation 0.7287394206794627 1.964963299905784 0.049418485388869 1.0 0.4010699031855333 8 O75718,O15460,P13674 3 +Peptide catabolic process 0.6994548141310553 1.9618527858085235 0.0497796260491172 1.0 0.4015764298476746 10 Q9UIQ6,P55786 2 +Intracellular lipid transport 0.7271437401261035 1.9575993818434256 0.0502770399614374 1.0 0.4027393578185362 8 P61916,O43772,P23786 3 +Protein insertion into membrane 0.5618132658085583 1.9547239946399924 0.0506156563838464 1.0 0.4044000561925995 22 Q8N4V1,P46379,O14737,Q15629,O43681,Q9NS69 6 +Guanine nucleotide transport 0.9216965742251232 1.949302799794172 0.0512592744329651 1.0 0.4059569509889325 2 O15439 1 +Guanine nucleotide transmembrane transport 0.9216965742251232 1.949302799794172 0.0512592744329651 1.0 0.4059569509889325 2 O15439 1 +Folate transmembrane transport 0.921696574225118 1.949302799794148 0.051259274432968 1.0 0.4059569509889325 2 Q9H2D1 1 +Folic acid transport 0.921696574225118 1.949302799794148 0.051259274432968 1.0 0.4059569509889325 2 Q9H2D1 1 +Endothelial cell migration 0.5296026344746537 1.9425372204104336 0.0520720985926181 1.0 0.4070638395926202 28 P42785,P04792,Q8WTV0,P09601 4 +Protein depalmitoylation 0.8755015875419456 1.935268114048615 0.0529574030341686 1.0 0.4070638395926202 4 P50897 1 +Macromolecule depalmitoylation 0.8755015875419456 1.935268114048615 0.0529574030341686 1.0 0.4070638395926202 4 P50897 1 +Lipoprotein catabolic process 0.8755015875419456 1.935268114048615 0.0529574030341686 1.0 0.4070638395926202 4 P50897 1 +Cytochrome complex assembly 0.770911937247426 1.933707487755807 0.0531491026966035 1.0 0.4070638395926202 7 Q9BSK2,Q69YU5 2 +Electron transport chain 0.4376283241624238 1.9320112766942696 0.0533581140420416 1.0 0.4070638395926202 53 O75306,P13804,O15460,Q9UDW1,Q16134,P04062,P00403,O43676,O14949,Q9Y375 10 +Response to reactive oxygen species 0.5582495322539647 1.9313430238856024 0.0534406461124254 1.0 0.4070638395926202 22 P00374,Q99720,O95831,P09601 4 +Regulation of hormone secretion 0.5881890374617282 1.9304813262337672 0.0535472267943486 1.0 0.4070638395926202 17 P30626,P51809,P04083,Q16836,P40939 5 +Cellular hormone metabolic process 0.6203277990688857 1.9233321181997949 0.0544383534184544 1.0 0.4070638395926202 14 Q9HB40,O94788,Q14849,Q8NBN7,P42892 5 +Protein insertion into er membrane 0.6303296421123483 1.9218894129274051 0.0546196742649804 1.0 0.4070638395926202 13 Q15629,O43681,Q8N4V1,P46379 4 +Positive regulation of cell migration involved in sprouting angiogenesis 0.9151712887438764 1.9218331109278608 0.0546267605649841 1.0 0.4070638395926202 2 P09601 1 +Positive regulation of viral genome replication 0.5858972621238343 1.9165953238778488 0.0552893625449235 1.0 0.4070638395926202 17 Q08752 1 +Post translational protein modification 0.6900503666566329 1.9162288875224536 0.0553359679178804 1.0 0.4070638395926202 10 O60725,Q9HA64 2 +Negative regulation of inflammatory response 0.8160857716598585 1.9135319844490883 0.0556799829303344 1.0 0.4070638395926202 6 P04062 1 +Purine nucleotide transport 0.7019407309467265 1.9055400682230996 0.0567099041680274 1.0 0.4109800113824107 9 P41440,Q8TB61,Q6NUK1,O43808,O15439,P12235,P12236 7 +Negative regulation of cell population proliferation 0.4167379271433213 1.8886718504613107 0.0589358127746926 1.0 0.416081994546864 75 Q13155,Q99627,Q9NR77,P09601,Q15392,Q96DY7,P37198,Q8IXJ6,P05067,Q9UIV1,Q96G23,O14737,P15531,Q99816,Q01085,Q96J02,Q9UII2,O95140,P17096,O94788 20 +Cellular lipid metabolic process 0.4061077435247264 1.888662082138672 0.0589371225059367 1.0 0.416081994546864 142 Q9HB40,Q06136,Q9H7Z7,P06280,Q8WTV0,P50897,P16278,P40939,Q15120,Q8N4Q0,Q16134,Q96G23,O75874,P23786,Q8NBX0,Q8NHP8,P07099,Q13510,Q99519,P61916,P48449,P13804,O75844,P04083,Q16836,P16219,P17900,Q9UG56,O94788,P04062,Q14914,P35790 32 +Response to hydrogen peroxide 0.5757655894664933 1.8884358340363048 0.0589674644869175 1.0 0.416081994546864 18 Q99720,O95831,P09601 3 +Cellular iron ion homeostasis 0.6632769410544777 1.8801872812565523 0.0600825583900119 1.0 0.4229812110656842 11 P61421,Q9Y487,Q15904,P09601 4 +Macroautophagy 0.4181514703306017 1.87865310213742 0.0602918753186565 1.0 0.4239702647978588 72 Q96AX1,Q9Y3C8,O95721,Q86Y82,Q9Y4P1,O00267,P21796,P09601,Q13501,P61421,P08754,Q9Y679,O43464,P62820,Q99816,P17612,O75436,Q93050,P12235,O15118,Q9UNZ2,O95140,P36543,Q8WUX9,P51809,P04062,Q9Y263,Q9Y487 28 +Cellular transition metal ion homeostasis 0.6014241290610669 1.8760261304386787 0.0606516918880688 1.0 0.4246200203693064 15 P61421,P05067,P09601,Q9Y487,Q15904 5 +Ion transport 0.4102070737776472 1.8737532906609848 0.0609644370899062 1.0 0.4251617101558241 154 Q9Y619,Q9UJS0,Q8TB61,Q9HD20,P08183,Q658P3,Q6NUK1,Q13423,P21796,O43808,O15439,Q9UJZ1,P36542,P45880,P61421,O43772,P05067,Q04917,P31930,O75947,Q02978,P78417,Q9H2D1,Q9UHG3,P41440,O75964,P56134,O75844,Q8N4V1,Q9H2J7,Q15041,O15173,P04083,P00403,Q9HC21,P20674,Q9Y277,Q9UM00,P55011,P12235,Q9C0H2,Q70HW3,P04899,Q9UDW1,P30626,P51809,P24539,Q06787,P13693,Q13642,Q9UBX3,O43681 52 +Regulation of mast cell activation involved in immune response 0.903752039151706 1.8736441064626517 0.0609794945204176 1.0 0.4251617101558241 2 P09601 1 +Negative regulation of transport 0.4362375682539607 1.8733978535929587 0.0610134661976864 1.0 0.4251617101558241 52 P05067,P30626,P04083,Q16836,P21796,Q16850,P40939,P09601 8 +Porphyrin containing compound metabolic process 0.6807405656763759 1.8708395858088256 0.0613673189036541 1.0 0.4267094290681005 10 P30519 1 +Lipid homeostasis 0.5726121834715648 1.8689325667010772 0.0616321967286448 1.0 0.4267094290681005 18 Q86YV9,P61916,O15118,Q8WTV0,Q9UHB6,Q6IAA8,Q15067,Q5BJF2 8 +Positive regulation of chemokine production 0.7554162235841965 1.8658773284302947 0.0620585302090568 1.0 0.4276068748185571 7 P09601 1 +Tetrapyrrole catabolic process 0.9724583984196932 1.8507714999923324 0.0642024328182171 1.0 0.4362714740443556 3 P30519 1 +Negative regulation of blood pressure 0.9688464065367174 1.836999854633652 0.0662099168468566 1.0 0.446520799408392 3 Q9HB40 1 +Inflammatory response 0.4396955899570595 1.824223193153125 0.0681183366056925 1.0 0.4546100794963766 50 P28070,P05067,P42785,P60900,Q8IV08,P04062,P04083,P09601,Q9BQE5 9 +Tail anchored membrane protein insertion into er membrane 0.6711273124193348 1.82373918429566 0.0681915119244565 1.0 0.4546100794963766 10 O43681,Q8N4V1,P49069,P46379 4 +Response to corticosteroid 0.5215703360312803 1.8185096746992229 0.0689862693781149 1.0 0.458520996219131 25 P04062,P04083,O95831,P16278 4 +Negative regulation of protein secretion 0.7930807199148417 1.8181033946582543 0.0690483312619796 1.0 0.458520996219131 6 Q16836,Q16850 2 +Respiratory chain complex iii assembly 0.9628722970216248 1.8141949376142448 0.0696477192835536 1.0 0.4596480030304716 3 Q9BSK2,Q69YU5 2 +Smad protein signal transduction 0.6962624617300783 1.8139340953226184 0.0696878727830416 1.0 0.4596480030304716 8 Q9UIQ6,Q96PK6 2 +Regulation of viral genome replication 0.5275590196444496 1.813334952805688 0.0697801754543552 1.0 0.4596480030304716 24 Q08752 1 +Intermembrane lipid transfer 0.8141661200792236 1.812434930605721 0.0699190196275671 1.0 0.4596480030304716 5 P61916,Q14849 2 +Positive regulation of fatty acid metabolic process 0.8890701468189246 1.8114799602376737 0.0700665883753532 1.0 0.4596480030304716 2 P04083 1 +Response to light intensity 0.8890701468189237 1.8114799602376708 0.0700665883753537 1.0 0.4596480030304716 2 Q8NBN7 1 +Ion homeostasis 0.4068725022770854 1.8063938967875257 0.0708568342352886 1.0 0.4599347722754248 78 P30519,P61421,P13693,P04899,P05067,Q9HD20,P30626,Q13642,P50897,Q9Y639,P09601,Q9UM00,Q93050,Q9Y487,O75503,O75880,Q15904,Q9UJZ1 18 +Nuclear transcribed mrna catabolic process exonucleolytic 0.6289663259428908 1.8043847638633523 0.071171009889345 1.0 0.4610625391113425 12 Q15024,Q9NQT5,Q9Y2L1,Q9UIV1,Q969T7,Q96C86 6 +Negative regulation of hormone secretion 0.8416802934869185 1.7990953579921924 0.0720035978287518 1.0 0.4610625391113425 4 Q16836,P40939 2 +Negative regulation of peptide secretion 0.8416802934869185 1.7990953579921924 0.0720035978287518 1.0 0.4610625391113425 4 Q16836,P40939 2 +Cellular response to oxygen levels 0.5060157328618355 1.7959177646576048 0.0725075967074166 1.0 0.4613862119499665 29 P61421,O75306,P55786,P07237,Q9Y4P3,O95831,P09601,Q15120,Q9Y487,Q15904 10 +Protein localization to synapse 0.664799279785048 1.7926080539369549 0.0730356176967657 1.0 0.4613862119499665 10 Q9UQB8,Q14168 2 +Organic hydroxy compound transport 0.5431942426992614 1.791538993575524 0.0732068430202212 1.0 0.4613862119499665 21 O15439,Q14849,Q8WTV0,Q9UHB6 4 +Plasma lipoprotein particle clearance 0.6629142066106524 1.783315081242604 0.0745350277887737 1.0 0.4613862119499665 10 Q8WTV0 1 +Establishment of protein localization to membrane 0.4116513099440021 1.7788970026836095 0.0752566496134803 1.0 0.4613862119499665 68 O15118,P49069,Q9HD20,Q15041,Q5W0Z9,P46379,Q8N4V1,O14737,P31751,Q15629,P43307,O43681,O60725,Q15904,Q9NS69 15 +Positive regulation of dephosphorylation 0.661703239724203 1.7773406653743975 0.07551220675551 1.0 0.4613862119499665 10 Q86XL3,P04062 2 +Positive regulation of protein dephosphorylation 0.661703239724203 1.7773406653743975 0.07551220675551 1.0 0.4613862119499665 10 Q86XL3,P04062 2 +Regulation of plasma lipoprotein particle levels 0.6234917509747904 1.775263350774568 0.0758544137851426 1.0 0.4613862119499665 12 Q8WTV0 1 +Low density lipoprotein particle clearance 0.6746604109309625 1.7749776982095002 0.0759015696543741 1.0 0.4613862119499665 9 Q8WTV0 1 +Regulation of monooxygenase activity 0.6879367779489503 1.7748346931728594 0.0759251860806449 1.0 0.4613862119499665 8 P00374,Q8WTV0 2 +Tetrapyrrole metabolic process 0.6233433893098903 1.774472933591391 0.075984955277889 1.0 0.4613862119499665 12 P30519 1 +Negative regulation of immune response 0.5725888506141732 1.7690630880761522 0.0768833469465344 1.0 0.4613862119499665 16 P28070,Q9UIV1,P09601 3 +Mast cell activation 0.8329581439431967 1.763732823156537 0.0777769722001191 1.0 0.4651516007308097 4 P09601 1 +Membrane protein proteolysis 0.6584075621442599 1.761062879260319 0.0782277609916966 1.0 0.4669408989426851 10 Q16740,O43847 2 +Cell migration involved in sprouting angiogenesis 0.7787355859006134 1.758162009789389 0.0787199472376212 1.0 0.4669700090716114 6 P09601 1 +Succinate transmembrane transport 0.876427406199022 1.7577777131789762 0.0787853388710233 1.0 0.4669700090716114 2 Q9UBX3 1 +Sulfate transport 0.876427406199022 1.7577777131789762 0.0787853388710233 1.0 0.4669700090716114 2 Q9UBX3 1 +Oxaloacetate transport 0.876427406199022 1.7577777131789762 0.0787853388710233 1.0 0.4669700090716114 2 Q9UBX3 1 +Tissue migration 0.466069179499457 1.7574620059776271 0.0788390924406616 1.0 0.4669700090716114 40 P07737,P04792,P42785,Q8WTV0,P04083,P09601 6 +Response to wounding 0.4137533099330218 1.7538169441356106 0.0794618787314371 1.0 0.4684191242553241 59 P42785,Q96G23,Q8WTV0,P00374,P09601 5 +Antigen processing and presentation of peptide antigen 0.5998365683237719 1.7538048101254549 0.0794639585790282 1.0 0.4684191242553241 13 Q9UIQ6 1 +Mitochondrial membrane organization 0.4703121888245459 1.750593772763518 0.0800159087034602 1.0 0.4707717264692597 38 P45880,Q8IWA4,Q9NX63,O14737,Q5XKP0,Q9NS69,Q13505 7 +Cellular carbohydrate metabolic process 0.4432031203719256 1.7487570796407117 0.0803330187635651 1.0 0.4715732166266835 47 Q14108,P85037,O75874,O75844,P31751,P16278,Q9NUJ1,Q15120,P48735,Q15185,P10253 11 +Tricarboxylic acid metabolic process 0.655862655346433 1.7484750728662524 0.0803817982886392 1.0 0.4715732166266835 10 P48735 1 +Purine containing compound transmembrane transport 0.7281641340574448 1.745468464832448 0.0809033571111288 1.0 0.4724804406888415 7 P41440,Q8TB61,O43808,O15439,P12235 5 +Mitophagy 0.5879358704332547 1.7402025313220784 0.081823461314878 1.0 0.4750264250958898 14 O95140,Q9Y4P1,O43464,P21796,Q13501 5 +Negative regulation of transmembrane transport 0.5772242749493183 1.7352743556573187 0.0826922217366374 1.0 0.4750264250958898 15 P31751,P30626,P21796,P78417 4 +Cellular response to inorganic substance 0.4943772812910625 1.7348122311353311 0.0827740690462168 1.0 0.4750264250958898 30 P05067,Q92542,Q9UNS1,Q6NUK1,O95831,P09601,Q14103,P55011,Q14168 9 +Regulation of leukocyte migration 0.5560371160989436 1.733706617469729 0.0829701517812158 1.0 0.4750264250958898 17 P05067,P09601 2 +Collateral sprouting in absence of injury 0.8707177814029318 1.7334770862319946 0.0830109067363111 1.0 0.4750264250958898 2 P05067 1 +Steroid hormone biosynthetic process 0.8254981062464732 1.7334123090197953 0.0830224113398818 1.0 0.4750264250958898 4 Q9UBM7,Q14849 2 +Regulation of nervous system process 0.6786367444198992 1.7309812076088005 0.0834551162628292 1.0 0.4750264250958898 8 Q9UQB8,P04062 2 +Regulation of secretion 0.4098131006944022 1.7303158472375462 0.0835738597179895 1.0 0.4750264250958898 63 P11279,P30626,Q08752,P04083,Q16836,Q16850,P11233,P40939,P09601 9 +Positive regulation of blood vessel endothelial cell migration 0.7240415161464152 1.727133587295146 0.0841436747537081 1.0 0.4750264250958898 7 P04792,P09601 2 +Regulation of nitric oxide synthase activity 0.7931805447992274 1.7256158237100745 0.0844165506856966 1.0 0.4750264250958898 5 P00374,Q8WTV0 2 +Positive regulation of monooxygenase activity 0.8205637973957316 1.7133205203612762 0.0866535892509945 1.0 0.4750264250958898 4 Q8WTV0 1 +Atp metabolic process 0.387111879999984 1.7111091831730794 0.0870609592519391 1.0 0.4750264250958898 90 P85037,O75306,Q9UDW1,P05067,P31930,Q9BSK2,O75964,P22695,Q9NTK5,P00403,P14406,P20674,O43676,O14949,Q9UII2,Q9Y375 16 +Antigen processing and presentation of peptide antigen via mhc class i 0.6292588989075715 1.7062229210575666 0.0879665827138751 1.0 0.4750264250958898 11 Q9UIQ6 1 +Regulation of response to external stimulus 0.3809524950026041 1.705414737748411 0.0881171016142989 1.0 0.4750264250958898 95 Q9NZ08,P28070,O43657,P04792,P11279,Q9UIV1,Q9BVA1,P05067,P80303,Q9UMX5,Q96G23,O75844,P04062,P60900,P51809,P04083,Q9NUD5 17 +Fatty acid beta oxidation using acyl coa dehydrogenase 0.6729726110359522 1.7041821295185244 0.0883470667316508 1.0 0.4750264250958898 8 Q16134,P13804 2 +Sterol transport 0.5509583032810126 1.7022426567937574 0.0887098893793161 1.0 0.4750264250958898 17 Q14849,Q8WTV0,Q9UHB6 3 +Ganglioside metabolic process 0.817596225292864 1.7012232276295238 0.0889010777799923 1.0 0.4750264250958898 4 P17900 1 +Ganglioside catabolic process 0.817596225292864 1.7012232276295238 0.0889010777799923 1.0 0.4750264250958898 4 P17900 1 +Regulation of steroid biosynthetic process 0.7179047899492099 1.699784907050635 0.089171391501555 1.0 0.4750264250958898 7 Q13510 1 +Regulation of lysosomal lumen ph 0.9327506612953422 1.6987319660495843 0.0893696975623106 1.0 0.4750264250958898 3 P50897 1 +Regulation of dna binding 0.5225310547254636 1.6936312410993417 0.0903353776640303 1.0 0.4750264250958898 22 Q8IXJ6,P30626,O75844,P18074,P09601 5 +Regulation of macroautophagy 0.4609739832549237 1.6925646639519014 0.0905383618896529 1.0 0.4750264250958898 39 P04062,P21796,P09601,Q93050,Q9Y487 5 +Negative regulation of ion transport 0.6263890888592398 1.691406480964489 0.0907591953465296 1.0 0.4750264250958898 11 P30626,P21796,P78417 3 +Negative regulation of ion transmembrane transport 0.6263890888592398 1.691406480964489 0.0907591953465296 1.0 0.4750264250958898 11 P30626,P21796,P78417 3 +Negative regulation of neuron apoptotic process 0.5213627318159348 1.685754154121522 0.0918431614778938 1.0 0.4750264250958898 22 P50897,P09601 2 +Adipose tissue development 0.7613600815821042 1.6851315431999516 0.0919631950749138 1.0 0.4750264250958898 6 P43490,Q8N0X7 2 +Regulation of synapse structure or activity 0.4937622203577395 1.6814767493482106 0.0926703488969302 1.0 0.4750264250958898 28 Q9UQB8,P50897,P07437 3 +Positive regulation of macroautophagy 0.5867027753186738 1.6804898146254812 0.0928620543747276 1.0 0.4750264250958898 13 P21796 1 +Organic cation transport 0.8122448979591815 1.6793830320644392 0.0930774180342108 1.0 0.4750264250958898 4 O43772,O43808,Q70HW3 3 +Cellular carbohydrate catabolic process 0.557430987332022 1.677752559710284 0.0933954140855839 1.0 0.4752027569717456 16 Q14108,Q9NUJ1 2 +Negative regulation of fat cell differentiation 0.7814217030836514 1.6767036553578971 0.0936004454762375 1.0 0.4754702917765681 5 Q8N4Q0,Q99523 2 +Glyoxylate metabolic process 0.926967948410584 1.6764816045545416 0.0936438964571579 1.0 0.4754702917765681 3 P48735 1 +Polyol metabolic process 0.5658014139984422 1.6681137245811934 0.0952931531763201 1.0 0.4799720552462241 15 P00374,Q13510,P04062 3 +Negative regulation of cell activation 0.6017054583773014 1.658516581579579 0.0972132434990626 1.0 0.4879553181863855 12 P04083,P09601,Q96J02 3 +Cellular response to nutrient 0.8070655774944194 1.6582143491764167 0.0972742095345586 1.0 0.4879553181863855 4 Q96C86,P09601 2 +Xenobiotic transport 0.9220726234190136 1.657626652288017 0.097392846699142 1.0 0.4881529175481815 3 O15439,P08183 2 +Regulation of oxidoreductase activity 0.5729569576248394 1.654322911037949 0.0980619202652526 1.0 0.4900540974123954 14 P00374,Q8WTV0 2 +Phosphatidylcholine metabolic process 0.6624511423058215 1.6542243153196547 0.0980819441518361 1.0 0.4900540974123954 8 Q8WTV0 1 +Peptidyl proline hydroxylation to 4 hydroxy l proline 0.7740585287038033 1.6459843617649057 0.0997669786960706 1.0 0.4945076034181682 5 P13674,O15460 2 +Biological process involved in interaction with host 0.4417726314579991 1.6448565317876396 0.0999994008171549 1.0 0.4945076034181682 44 Q14108,P11279,Q86V81,Q08752,Q8WTV0,P07237,Q9BTY2,Q99816,Q96J02 9 +Retinal rod cell development 0.8499184339314871 1.6447304928527149 0.1000254016004931 1.0 0.4945076034181682 2 Q15555 1 +Camera type eye photoreceptor cell differentiation 0.8499184339314871 1.6447304928527149 0.1000254016004931 1.0 0.4945076034181682 2 Q15555 1 +Retinal rod cell differentiation 0.8499184339314871 1.6447304928527149 0.1000254016004931 1.0 0.4945076034181682 2 Q15555 1 +Atp synthesis coupled electron transport 0.4913696263809173 1.642231667822121 0.100542002164184 1.0 0.4948239429836825 27 O75306,Q9UDW1,P00403,O43676,O14949,Q9Y375 6 +Oligosaccharide catabolic process 0.9177407682825351 1.6409280790457816 0.100812345526708 1.0 0.4948239429836825 3 P17900 1 +Chemokine production 0.658999825397701 1.6377878775441312 0.1014659512496498 1.0 0.4964497694184615 8 P09601 1 +Pteridine containing compound metabolic process 0.5505097861398072 1.6357784198851453 0.1018859700760932 1.0 0.4978305631829532 16 P41440,Q9NRN7,P35270,P00374,Q9H2D1 5 +Positive regulation of mitochondrial translation 0.7715085288105366 1.6353299106931989 0.1019799065856437 1.0 0.4978305631829532 5 Q92552,Q567V2,Q07021 3 +Protein targeting to membrane 0.4926228456411035 1.631408191169152 0.1028042176620818 1.0 0.5006118425283984 26 Q5W0Z9,P46379,Q15629,P31751,P43307,O60725,O43681 7 +Positive regulation of lipase activity 0.7012174888823255 1.6250870812268423 0.1041440051770403 1.0 0.5051394266854872 7 Q9Y263,P18085 2 +Regulation of nuclear transcribed mrna catabolic process nonsense mediated decay 0.7963883554537458 1.614484366661418 0.1064224051183919 1.0 0.5141796338885042 4 Q99729 1 +Neuron death 0.3994085165057717 1.6144638177180624 0.1064268589059536 1.0 0.5141796338885042 62 Q01105,Q9NR28,P05067,Q9UMX5,P04062,Q99720,O43464,P31751,P50897,O95831,P09601,Q15392 12 +Myeloid leukocyte activation 0.5933416608721973 1.6133447968823424 0.106669619197663 1.0 0.5141796338885042 12 P04083,P05067,P09601 3 +Organic hydroxy compound catabolic process 0.6538441851912613 1.6131908797176306 0.1067030442823326 1.0 0.5141796338885042 8 P05091,P21964,P30837,Q8WTV0 4 +Sphingosine biosynthetic process 0.9104856202007616 1.6129330651880174 0.1067590506076943 1.0 0.5141796338885042 3 Q13510 1 +Metal ion homeostasis 0.3987593845998061 1.611948984838399 0.1069730414523613 1.0 0.5147585340745059 63 P30519,P61421,P13693,Q9Y487,P04899,P05067,Q9HD20,P30626,O75880,Q9Y639,P09601,Q15904,Q9UM00,Q9UJZ1 14 +Neuron maturation 0.7658387573227303 1.611612095442425 0.107046376972312 1.0 0.5147585340745059 5 O75503 1 +Secretion 0.3658880912243449 1.6101279768194612 0.1073699206148488 1.0 0.5154043703618187 107 Q86YV9,Q9H7Z7,O95721,Q08752,P50897,P40939,P09601,O15439,Q9BRK5,P62820,P15531,Q16850,P11233,Q13505,P04083,P00403,Q16836,P11279,P30626,P51809 20 +Protein localization to microtubule end 0.8417618270799367 1.6098450380566791 0.1074316901858076 1.0 0.5154043703618187 2 Q15555 1 +Export across plasma membrane 0.6969225908720263 1.6057864655985843 0.1083208354009479 1.0 0.516992866004772 7 P08183 1 +Retinoic acid metabolic process 0.9078993866694116 1.6029457804994485 0.1089466251073116 1.0 0.5178327242754938 3 Q9HB40 1 +External encapsulating structure organization 0.5198751917552875 1.6015275058292255 0.109260132844327 1.0 0.5179827023686236 20 P41440,P05067,O75718,P18074,P13674,Q92791 6 +Glial cell proliferation 0.9073812906191336 1.6009445626117755 0.109389198345341 1.0 0.5179827023686236 3 Q96G23 1 +Nadh dehydrogenase complex assembly 0.5246604820788727 1.598997268707974 0.109821209485126 1.0 0.5191854569672882 19 O75306,Q8N183,Q9H061,O43676,Q9P032,Q9Y375 6 +Lipid catabolic process 0.3994856604519061 1.5970245048008689 0.1102602450131224 1.0 0.5204621527056204 57 P17900,P13804,Q16134,P06280,O75874,P04062,Q8WTV0,P23786,P50897,Q8NHP8,Q9H6V9,P40939,Q16836,P16219,Q13510,Q99519 16 +Regulation of dna methylation 0.6493245468235097 1.5915856893358904 0.1114778276746597 1.0 0.5217312165017728 8 Q03164,O75844 2 +Regulation of fat cell differentiation 0.6367315164204242 1.5906252146558435 0.1116939464294244 1.0 0.5217312165017728 9 Q8N4Q0,Q99523 2 +Entry into host 0.4835494748101973 1.5848013242598034 0.1130114814405611 1.0 0.5217312165017728 27 Q14108,P11279,Q8WTV0,P07237,Q9BTY2,Q96J02 6 +Negative regulation of calcium ion transmembrane transport 0.7590474280979265 1.5831528110540842 0.1133866390449389 1.0 0.5217312165017728 5 P30626,P21796,P78417 3 +Negative regulation of calcium ion transport 0.7590474280979265 1.5831528110540842 0.1133866390449389 1.0 0.5217312165017728 5 P30626,P21796,P78417 3 +Positive regulation of long term synaptic potentiation 0.7589817416555543 1.5828772924298211 0.1134494353071697 1.0 0.5217312165017728 5 P05067,Q13501 2 +Copper ion homeostasis 0.8352365415986875 1.5819088217228712 0.1136703867693356 1.0 0.5217312165017728 2 P05067 1 +Cellular copper ion homeostasis 0.8352365415986875 1.5819088217228712 0.1136703867693356 1.0 0.5217312165017728 2 P05067 1 +Positive regulation of phospholipase activity 0.7368050763499083 1.5811813191745316 0.1138365854222938 1.0 0.5217312165017728 6 Q9Y263,P18085 2 +Homologous chromosome pairing at meiosis 0.7367964695882832 1.581144740564817 0.1138449468903748 1.0 0.5217312165017728 6 Q92791,Q9BTX1 2 +Natural killer cell mediated immunity 0.6344941063504782 1.5796543945832693 0.1141860350456465 1.0 0.5220555835771888 9 P11279,P07437,P68371 3 +Positive regulation of epithelial cell proliferation 0.5871196181540321 1.579618569480672 0.1141942440510968 1.0 0.5220555835771888 12 P26583,Q9NQC3,O75340,Q9H2J4,P15531,P09601 6 +Modification of postsynaptic structure 0.6905493217211459 1.5770915842797295 0.1147744533628425 1.0 0.522097875172964 7 Q9UQB8 1 +Glycosaminoglycan catabolic process 0.7869387755102015 1.5756866581493525 0.1150980337072316 1.0 0.522097875172964 4 P15586,P54802,P16278 3 +Aminoglycan catabolic process 0.7869387755102015 1.5756866581493525 0.1150980337072316 1.0 0.522097875172964 4 P15586,P54802,P16278 3 +Digestive system process 0.6211951728341499 1.5754812877568247 0.1151453943405877 1.0 0.522097875172964 10 Q8WTV0 1 +Purine ribonucleoside metabolic process 0.645924674422213 1.5753076791258076 0.115185442322331 1.0 0.522097875172964 8 O60725 1 +Ribonucleoside metabolic process 0.645924674422213 1.5753076791258076 0.115185442322331 1.0 0.522097875172964 8 O60725 1 +Apoptotic cell clearance 0.6882627507654357 1.5667810961724915 0.1171658674853977 1.0 0.5251619360562856 7 Q8WTV0 1 +Collateral sprouting 0.784347135302462 1.5650312519947525 0.1175755816599122 1.0 0.5251619360562856 4 P05067 1 +Fatty acid transmembrane transport 0.7528458601895978 1.5571195624461989 0.119442101291308 1.0 0.5273025181129478 5 O43772,P23786 2 +Regulation of cell migration involved in sprouting angiogenesis 0.8954606258618966 1.5548578745860238 0.1199799219510964 1.0 0.5273025181129478 3 P09601 1 +Positive regulation of oxidoreductase activity 0.6842957688840959 1.5488744632207807 0.1214119008209633 1.0 0.5281176452333127 7 Q8WTV0 1 +Macrophage differentiation 0.7498192011738586 1.5443990059253012 0.1224917007253152 1.0 0.5310758093908515 5 P04062 1 +Regulation of anion transport 0.6147089034764895 1.5428159053545194 0.1228754492263592 1.0 0.5319133993214148 10 P55011,Q15041,P14174,P08183 4 +Aminoglycan metabolic process 0.5791955306515632 1.5365207903453508 0.1244107027616894 1.0 0.5349927247012841 12 O43505,Q8NCH0,P54802,O60701,P16278,P15586 6 +Long chain fatty acid transport 0.6134330866702362 1.536380405469179 0.1244451096296608 1.0 0.5349927247012841 10 P04083,O43772,P23786 3 +Folic acid containing compound metabolic process 0.551931762744502 1.5325742472971355 0.1253807907528055 1.0 0.5382199798169213 14 P00374,P41440,Q9NRN7,Q9H2D1 4 +Neuron apoptotic process 0.4263228306899586 1.5316085965516548 0.1256190498818432 1.0 0.5388672334764306 45 Q01105,Q9NR28,P05067,P04062,P31751,P50897,O95831,P09601,Q99720 9 +Response to activity 0.6244402775668932 1.5302342630383394 0.1259587532247912 1.0 0.5392205495219717 9 Q16836,P40939 2 +Nuclear transcribed mrna catabolic process deadenylation dependent decay 0.4982607238766967 1.5287290166863363 0.1263316358093131 1.0 0.5392205495219717 22 Q15024,Q9UIV1,Q9Y2L1,Q969T7,Q9NQT5,Q96C86,O60506,Q14103 8 +Regulation of systemic arterial blood pressure 0.7241606690572829 1.5273422466487108 0.1266759294557722 1.0 0.5392205495219717 6 P42785 1 +Signal release 0.4437455461934118 1.5271571972954283 0.1267219268780106 1.0 0.5392205495219717 38 O95721,P30626,P51809,P04083,P50897,Q16836,P40939,O15439 8 +Cellular lipid catabolic process 0.4126795635805087 1.5262632350717995 0.1269443207856744 1.0 0.5392205495219717 49 P17900,P13804,Q16134,P06280,O75874,P04062,Q8WTV0,P23786,P50897,Q8NHP8,Q16836,P40939,P16219,Q13510,Q99519 15 +Membrane raft organization 0.623571448287145 1.52595429430703 0.1270212475787668 1.0 0.5392205495219717 9 P41440,P50897,P60903 3 +Negative regulation of ryanodine sensitive calcium release channel activity 0.8217781402936366 1.524226542056343 0.1274521298870115 1.0 0.5392205495219717 2 P30626 1 +Positive regulation of sequestering of calcium ion 0.8217781402936366 1.524226542056343 0.1274521298870115 1.0 0.5392205495219717 2 P30626 1 +Negative regulation of calcium ion transport into cytosol 0.8217781402936366 1.524226542056343 0.1274521298870115 1.0 0.5392205495219717 2 P30626 1 +Protein import 0.3867305965997513 1.517465358675809 0.1291492332215231 1.0 0.5419341121557103 70 O60830,Q99595,O14737,O95831,Q9UI26,Q9NS69,Q13501 7 +Neuropeptide signaling pathway 0.8197389885807516 1.5154807161826735 0.1296507101978437 1.0 0.5421997165409427 2 Q99523 1 +Regulation of steroid metabolic process 0.6092928481265701 1.515473141609284 0.1296526270235078 1.0 0.5421997165409427 10 Q13510 1 +Regulation of leukocyte degranulation 0.7720481497833426 1.5143844949241962 0.1299283494558096 1.0 0.542784861662971 4 P11279,P09601 2 +Regulation of lipid catabolic process 0.7426487446291737 1.5142250209489936 0.1299687777520912 1.0 0.542784861662971 5 Q8WTV0 1 +Protein quality control for misfolded or incompletely synthesized proteins 0.590633161044719 1.5050978458220836 0.1322989227732565 1.0 0.549535646853176 11 Q16740,Q9BUN8,P46379 3 +Positive regulation of anion transmembrane transport 0.7696586420839249 1.5045301978633432 0.1324449039197532 1.0 0.5495793453418005 4 P08183 1 +Modification of postsynaptic actin cytoskeleton 0.7403078320161998 1.5043631858111306 0.1324878778948983 1.0 0.5495793453418005 5 Q9UQB8 1 +Response to mitochondrial depolarisation 0.62954645179818 1.4965964593598535 0.1344982919797184 1.0 0.5524147621232822 8 Q13501,P04062,Q9UII2,O43464 4 +Export from cell 0.3596663629782695 1.4955928040868411 0.1347597994927232 1.0 0.5524147621232822 99 Q86YV9,P11279,O95721,Q9BRK5,P30626,P51809,P08183,Q08752,P04083,P50897,Q16836,P62820,Q16850,P09601,P40939,O15439,P11233 17 +Homologous chromosome segregation 0.6722341158727491 1.4942873798933107 0.1351005222490071 1.0 0.5531865051089541 7 Q92791,Q9BTX1 2 +Ethanol catabolic process 0.8144371941272364 1.492735821963916 0.1355063525687581 1.0 0.5538898316288887 2 P30837 1 +Primary alcohol catabolic process 0.8144371941272364 1.492735821963916 0.1355063525687581 1.0 0.5538898316288887 2 P30837 1 +Positive regulation of vasculature development 0.5361455923601128 1.4917109301138591 0.1357749424934451 1.0 0.5538898316288887 15 Q9NZ08,P04792,P09601 3 +Cellular ion homeostasis 0.385909161049779 1.4912961110935354 0.1358837695091441 1.0 0.5539669226845322 67 P61421,P13693,P05067,Q9HD20,P30626,P50897,P09601,O75503,Q9Y487,Q93050,Q15904 11 +Cell recognition 0.5080369330935762 1.4909169745598094 0.1359832941918861 1.0 0.554006013374351 19 P45880,P05067,Q9Y639,Q8WTV0 4 +Positive regulation of receptor mediated endocytosis 0.6712859737137113 1.4899877125235557 0.136227466793497 1.0 0.5540145307909751 7 P50897,P61978 2 +Mast cell activation involved in immune response 0.8784829682588702 1.4891030640379932 0.1364602310879785 1.0 0.554482205476219 3 P09601 1 +Lipid droplet organization 0.6701745060467458 1.4849458372668307 0.1375581723778314 1.0 0.5553082712920515 7 Q9Y679,Q08752 2 +Response to acid chemical 0.5068507820258048 1.4831648413116048 0.1380306199079757 1.0 0.5557389353186065 19 Q9Y2Q5,Q9UQB8,Q99729,Q6IAA8,O95831,Q14103 6 +Plasma membrane to endosome transport 0.7643972568057056 1.482817135616842 0.1381230020724386 1.0 0.5557398385148414 4 P61020 1 +Regulation of response to extracellular stimulus 0.8767727862206887 1.4824733095438007 0.1382144003061203 1.0 0.5557445860872723 3 P80303 1 +Autophagy of mitochondrion 0.4665350574843864 1.4784367849890594 0.1392909055897331 1.0 0.5582511245496136 28 Q9BWH2,O95140,P04062,O43464,Q9Y4P1,P21796,Q9UII2,Q13501 8 +Positive regulation of anion transport 0.6673324825332458 1.472046237271293 0.1410083920651441 1.0 0.5596850318224282 7 P55011,Q15041,P14174,P08183 4 +Selective autophagy 0.4949899987094199 1.4702981888274622 0.141481011376124 1.0 0.5596850318224282 21 O95140,Q9Y679,O43464,Q9Y4P1,P21796,P12235,Q13501 7 +Protein processing 0.4327444347053762 1.4702527842666997 0.1414933035919408 1.0 0.5596850318224282 40 P60903,Q9UG56,Q92542,O75844,O43464,Q10713,P78536,Q5JRX3,O75503,Q15392,Q99797,Q9UJZ1,P42892,P67812 14 +Connective tissue development 0.5412165629031847 1.470018656382264 0.1415567012304128 1.0 0.5596850318224282 14 P43490,O75844,Q8N0X7 3 +Skeletal muscle tissue regeneration 0.760815637560275 1.4680249307469917 0.1420974510169457 1.0 0.560384313869645 4 P04083 1 +Gamma aminobutyric acid signaling pathway 0.8079119086460047 1.464733167931972 0.1429937319622163 1.0 0.5621692658300147 2 P04899 1 +Wound healing 0.4190060509848923 1.4639202303709635 0.1432157451187563 1.0 0.5626332843951143 45 P04792,P42785,Q8WTV0,P04083,P09601 5 +Digestion 0.5826306974668738 1.462997228133829 0.1434681374179902 1.0 0.5630790499486741 11 Q8WTV0 1 +Hormone biosynthetic process 0.7073712730824091 1.4555648282149054 0.1455129568698101 1.0 0.5656574798247141 6 Q9UBM7,Q14849 2 +Leukocyte degranulation 0.7071469454487769 1.4546037402679637 0.1457789949545067 1.0 0.5656574798247141 6 P11279,P09601 2 +Walking behavior 0.755475505054323 1.4459542103087752 0.1481900453783258 1.0 0.5712146596228969 4 O75844,O43464 2 +Signal peptide processing 0.7259964536338706 1.443963386445617 0.1487492747400156 1.0 0.5715253693090078 5 O75503 1 +Isoprenoid metabolic process 0.5005038132596251 1.4415967409439978 0.1494161683814112 1.0 0.5715253693090078 19 Q9HB40,P61916,P48449,O94788,O43464,Q8NBN7 6 +Regulation of aerobic respiration 0.578537370446496 1.4414105593012734 0.1494687288890928 1.0 0.5715253693090078 11 P14406 1 +Response to estrogen 0.5945848929862536 1.4409289730947912 0.1496047498179864 1.0 0.5716906072449109 10 P09601 1 +Axon ensheathment in central nervous system 0.8013866231647562 1.436724407245743 0.1507963169462249 1.0 0.5748176438049171 2 P18074 1 +Camera type eye morphogenesis 0.7234456587955458 1.4331799038671438 0.1518064311695952 1.0 0.5772392691387078 5 Q15555,O95140,Q8NBN7 3 +Sensory perception of light stimulus 0.5348401716293977 1.4326411745436711 0.1519604085352563 1.0 0.5774683014047991 14 Q15555,P50897,Q99797 3 +Modification of synaptic structure 0.6042667150966072 1.4305031732046134 0.1525726557340871 1.0 0.5794374595080006 9 Q9UQB8,P07737,P35080 3 +Regulation of anion transmembrane transport 0.7008872073069907 1.42776499554711 0.1533595113317658 1.0 0.580279232066141 6 P08183 1 +Carbohydrate catabolic process 0.4175552416026672 1.424367022571054 0.1543402552293227 1.0 0.5806439282453036 44 Q14108,P17900,P05067,P16278,Q9NUJ1,P10253,Q99519 7 +Negative regulation of exocytosis 0.6561987270246789 1.421411985518952 0.1551970241273652 1.0 0.5819367563187199 7 P04899,P04083,P09601 3 +Leukocyte mediated cytotoxicity 0.5578228828651336 1.4195145615857951 0.155749054608834 1.0 0.5825222686037751 12 P11279,P07437,P68371 3 +Regulation of receptor mediated endocytosis 0.5012350839698079 1.4167016200811824 0.156570183192592 1.0 0.5838210220740722 18 P50897,P05067 2 +Regulation of neuronal action potential 0.7960848287112435 1.4139657065777282 0.1573719717547967 1.0 0.5853933248849928 2 P04062 1 +Regulation of transmission of nerve impulse 0.7960848287112435 1.4139657065777282 0.1573719717547967 1.0 0.5853933248849928 2 P04062 1 +Outer mitochondrial membrane organization 0.7181750136934415 1.4108826769838008 0.1582792108437729 1.0 0.5876826589700722 5 Q9NS69 1 +Regulation of mast cell activation 0.8558999346239105 1.4014964119140016 0.1610656797678702 1.0 0.5920478878644309 3 P09601 1 +Regulation of peptide transport 0.5290112562969138 1.3983788529728585 0.1619993300451059 1.0 0.5920478878644309 14 P30626,Q16836,P40939 3 +Regulation of amyloid fibril formation 0.714685421831483 1.3961092760523477 0.1626815909057382 1.0 0.5920478878644309 5 Q99471,P05067 2 +Negative regulation of neuron death 0.4372040278174571 1.3955584966231709 0.1628474878800825 1.0 0.5920478878644309 34 P50897,P09601,Q9UMX5 3 +Regulation of neuronal synaptic plasticity 0.6086411461972188 1.395481208264556 0.1628707776490141 1.0 0.5920478878644309 8 P05067,P61006,Q96A49,Q9Y639,Q15042 5 +Chemical synaptic transmission postsynaptic 0.5854151398172341 1.3942534710140908 0.1632410761276863 1.0 0.5920478878644309 10 Q9UQB8,Q14168 2 +Regulation of postsynaptic membrane potential 0.5854151398172341 1.3942534710140908 0.1632410761276863 1.0 0.5920478878644309 10 Q9UQB8,Q14168 2 +Atp transport 0.7129740332883363 1.3888610504942869 0.164875006423804 1.0 0.5939356956553408 5 Q6NUK1,P12235,O43808 3 +Regulation of defense response 0.3766004720864747 1.3878488286520951 0.1651830825776967 1.0 0.5946913194964976 67 Q9NZ08,P28070,Q8IXJ6,P11279,O43657,Q9UIV1,P05067,Q96PK6,Q8WXF1,P60900,O75844,P04062,P51809,P04083,Q96J02,Q9NUD5 16 +Response to testosterone 0.6061334920572063 1.3833086587703902 0.1665702441708936 1.0 0.5963419279239278 8 Q13126 1 +Cellular modified amino acid metabolic process 0.412966084837735 1.382107164288688 0.1669387990330553 1.0 0.5963419279239278 44 P41440,Q9NRN7,Q9H7Z7,O75874,P23786,P00374,Q9H2D1,Q9UHG3,O60725 9 +Regulation of phospholipase a2 activity 0.8506731946144488 1.3812084863451384 0.167214866211582 1.0 0.5963419279239278 3 P04083,P50897 2 +Collagen fibril organization 0.6055511989084303 1.3804808950639376 0.1674386280133393 1.0 0.5963419279239278 8 P13674,Q92791 2 +Retina morphogenesis in camera type eye 0.8502651978784198 1.3796247588454942 0.1677022102122247 1.0 0.5963419279239278 3 Q15555,Q8NBN7 2 +Eye photoreceptor cell development 0.8502651978784198 1.3796247588454942 0.1677022102122247 1.0 0.5963419279239278 3 Q15555,Q8NBN7 2 +Associative learning 0.5823195289360185 1.3784642511583678 0.1680599978694705 1.0 0.5963419279239278 10 P50897,P05067 2 +Regulation of insulin secretion 0.5328893526276179 1.374856145789224 0.1691760474477897 1.0 0.5979475446397186 13 P30626,Q16836,P40939 3 +Pyridine containing compound metabolic process 0.6459786459260723 1.374804780373301 0.1691919756991931 1.0 0.5979475446397186 7 P43490 1 +Terpenoid metabolic process 0.5073388964821057 1.3702857091652365 0.1705977322986298 1.0 0.5983513606234907 16 Q9HB40,P48449,O94788,O43464,Q8NBN7 5 +Pyrimidine nucleoside triphosphate metabolic process 0.5910459904516272 1.364777557720644 0.1723229744858039 1.0 0.6010812700071076 9 Q9H773,P23919,P15531,P04818,P17812 5 +Multi multicellular organism process 0.4839565895282723 1.362858731106341 0.1729270371574713 1.0 0.6028469433446654 20 P41440,Q9UIQ6,Q9BQE5 3 +Peripheral nervous system development 0.5900154345830941 1.359643366194373 0.1739428078834408 1.0 0.6030465324140707 9 P31751,Q9NR77,Q8IXJ6 3 +Terpenoid biosynthetic process 0.7058387127120558 1.3586216670922926 0.1742665056923629 1.0 0.6030465324140707 5 P48449 1 +Regulation of protein folding 0.8442680172857078 1.3563452840985506 0.1749893336170973 1.0 0.6032895611499624 3 Q9H2J4 1 +Negative regulation of defense response 0.4678616496556249 1.3544643561205418 0.1755882776724022 1.0 0.6032895611499624 23 P28070,O43657,Q8IXJ6,Q9UIV1,P04062,Q96J02 6 +Positive regulation of actin filament polymerization 0.5887469730057838 1.3533219106505825 0.1759528123838674 1.0 0.6034907150805251 9 Q9UQB8,P62993,P07737 3 +Alcohol catabolic process 0.6821595049572112 1.3472612860229447 0.1778960958986188 1.0 0.6044346115474309 6 P05091,P30837,Q8WTV0 3 +Fatty acid transport 0.5440114775857345 1.343367436664458 0.1791530256149538 1.0 0.6056279912079385 12 P04083,O43772,P23786,P31751 4 +Hormone transport 0.4761541964692387 1.3421914137775603 0.1795339397533353 1.0 0.605948012756777 21 P30626,P51809,P62820,P04083,Q16836,P40939 6 +Regulation of cellular respiration 0.5270696565837348 1.341360335807778 0.1798034889814288 1.0 0.605948012756777 13 P14406 1 +Organelle membrane fusion 0.4933037323175343 1.3383854743794958 0.1807708115126967 1.0 0.605948012756777 17 Q8IWA4,P04083,P51809,O95721 4 +Negative regulation of dna binding 0.6378545034885075 1.33767865886551 0.1810012107107095 1.0 0.605948012756777 7 P09601 1 +Cell maturation 0.4846913972721733 1.337429667406714 0.1810824258499457 1.0 0.605948012756777 19 O75503,P04062,P05067,P18074 4 +Negative regulation of immune effector process 0.6797272011370229 1.3367858083387156 0.1812925629075876 1.0 0.605948012756777 6 P09601 1 +Negative regulation of lyase activity 0.7777324632952722 1.335210595282506 0.1818074300784689 1.0 0.6069478377939876 2 P04899 1 +Negative regulation of adenylate cyclase activity 0.7777324632952722 1.335210595282506 0.1818074300784689 1.0 0.6069478377939876 2 P04899 1 +Monocarboxylic acid transport 0.6370885864841449 1.3341753429622567 0.1821463983419695 1.0 0.6071546611398986 7 O15439,P04083,P28288,P14174 4 +Negative regulation of cation channel activity 0.7281749117774697 1.3328907662573413 0.1825676532056985 1.0 0.607241746017119 4 P30626,P78417 2 +Cell death in response to oxidative stress 0.4837991637553807 1.3315276270535474 0.1830154607683316 1.0 0.607241746017119 19 Q9NR28,P04792,P04062,O43464,P07237,Q99720 6 +Skin development 0.4442080519076078 1.328678779240336 0.1839539689346119 1.0 0.607241746017119 29 O75844,P04062,P18074,P04083,Q99816,Q15185,Q13510,Q15392 8 +Positive regulation of autophagy 0.4831777331264597 1.32741546971467 0.1843712851646584 1.0 0.6076656589696606 19 P21796 1 +Neural retina development 0.6349220991966644 1.324263014077892 0.1854157094702309 1.0 0.6092979154762029 7 Q15555,Q8NBN7,O96019 3 +Protein localization to phagophore assembly site 0.7260621488523948 1.324129623821941 0.1854599986230325 1.0 0.6092979154762029 4 O95140 1 +Endoplasmic reticulum organization 0.4233255570784014 1.3225624418169435 0.1859809312649492 1.0 0.6100332995698015 36 Q9NQC3,O95197,P49069,P57088,Q15041,Q8N4V1,P46379,Q15629,Q7L5D6,Q15042,O15027,Q96A33,O43681 13 +Carbohydrate derivative catabolic process 0.4374416819569336 1.3192979117903996 0.1870695356787912 1.0 0.6117493216247845 31 P17900,Q9H773,Q13126,P06280,P04062,O60502,Q9BTY2,P16278,Q9NUJ1 9 +Mononuclear cell migration 0.4860215194886533 1.3179053087842756 0.187535348342863 1.0 0.6117493216247845 18 P05067,P04062,P04083,P78536,Q07021,P55011 6 +Keratan sulfate metabolic process 0.8343533251734052 1.317864066674836 0.1875491564850331 1.0 0.6117493216247845 3 O43505,P16278 2 +Isoprenoid biosynthetic process 0.6750467352020445 1.316617079589626 0.1879670108322511 1.0 0.611985616663143 6 P48449 1 +Detection of stimulus 0.5700016767497302 1.3154905713721885 0.1883450840614089 1.0 0.6125176149495004 10 Q9UNS1,Q8WTV0 2 +Regulation of cholesterol metabolic process 0.7239164219123373 1.3152308224639475 0.1884323392646028 1.0 0.6125176149495004 4 Q9UBM7 1 +Cellular response to arsenic containing substance 0.632662117736168 1.31391868593747 0.1888735697278332 1.0 0.6129932505392268 7 P09651,P09601 2 +Regulation of long term neuronal synaptic plasticity 0.6949685132942487 1.312503396189208 0.1893503408971297 1.0 0.6131814165869385 5 P05067 1 +Regulation of epidermal growth factor activated receptor activity 0.7230714781859905 1.3117264217354945 0.1896124585265008 1.0 0.6131814165869385 4 P05067,Q99816 2 +Pyrimidine deoxyribonucleotide biosynthetic process 0.722991245738501 1.3113936517243914 0.1897248025025779 1.0 0.6131814165869385 4 P23919,P04818 2 +Myeloid cell activation involved in immune response 0.6946376697251323 1.3110989602894436 0.1898243319981494 1.0 0.6131814165869385 5 P09601 1 +Chloride transport 0.6318341086133923 1.3101277004705654 0.1901526389619032 1.0 0.613909987424174 7 Q9UHG3,Q9C0H2 2 +Membrane organization 0.3747125148196309 1.3075239448121914 0.1910348281195819 1.0 0.6148247341779649 171 O95721,Q86XL3,P08183,P46379,P31751,P50897,Q15392,Q9NS69,P45880,P60903,Q8IXJ6,Q14849,O14737,P62820,Q13505,Q8IWA4,P41440,P61916,O75340,Q9UQB8,O75844,Q8N4V1,Q9NX63,Q15041,Q15629,P04083,Q9UII2,O75431,O15118,O95140,P51809,Q5XKP0,Q00169,O43681 34 +Notch receptor processing 0.7703915171288749 1.3037368212348557 0.1923233303734155 1.0 0.6170373516147082 2 Q92542 1 +Regulation of endocytosis 0.4290555073872181 1.301282575208144 0.193161749344314 1.0 0.6187575027317331 33 P41440,P05067,P61978,P61020,P50897,Q8N6T3,Q99816 7 +Endocytosis 0.3587308453173592 1.2994121670156968 0.1938025183817937 1.0 0.6187575027317331 84 Q14108,P41440,O15118,Q5VW38,P05067,Q99523,P61020,Q9Y217,P51809,Q8WTV0,P62820,P50897,P15531,Q99816,P62993,Q08380 16 +Middle ear morphogenesis 0.7691680261011458 1.2984936620608336 0.194117752827343 1.0 0.6192466894958224 2 P54802 1 +Response to toxic substance 0.4131796288437097 1.2981869335948295 0.1942231070020208 1.0 0.6192620802962983 40 O14880,P00374,Q15165,O95831,P07099 5 +Water soluble vitamin metabolic process 0.4866446012367088 1.2956586113136357 0.1950931265861983 1.0 0.62033672082699 17 P41440,Q96EY8,Q9NRN7,Q8NFF5,P00374,P78417,Q9H2D1 7 +Ovulation cycle 0.6907258469251656 1.2944903427236585 0.1954961029177091 1.0 0.6210706518685345 5 P04083 1 +Negative regulation of establishment of protein localization 0.4863656094523117 1.2938658721378375 0.1957117545731399 1.0 0.6213924956083366 17 Q16836,Q16850 2 +Negative regulation of regulated secretory pathway 0.7185485955176505 1.2929660259696758 0.196022809679041 1.0 0.6217819297749192 4 P04899,P09601 2 +Lactation 0.5872827768708457 1.2915528325804146 0.1965120475057593 1.0 0.6226924962116654 8 P00403,Q13505 2 +Cellular response to cold 0.7671288743882531 1.2897568705504523 0.1971350869754951 1.0 0.6243455710894857 2 Q13217 1 +Positive regulation of ligase activity 0.7667210440456806 1.2880097960119978 0.1977425532046566 1.0 0.6250108914938874 2 Q13155 1 +Regulation of ligase activity 0.7667210440456806 1.2880097960119978 0.1977425532046566 1.0 0.6250108914938874 2 Q13155 1 +Protein maturation 0.3698029405324887 1.2867494448682346 0.1981816330137129 1.0 0.6260506971099855 60 P60903,Q9NRN7,Q9UG56,O75844,O43464,P49366,Q5JRX3,O75503,Q86UY6,Q15392,Q99797,Q9UJZ1,P42892,P67812 14 +Vascular transport 0.5633120437019815 1.2812020321185222 0.2001227125461548 1.0 0.6279958783924168 10 O15439,P08183 2 +Histone h4 k16 acetylation 0.6250701350213086 1.2791398403128609 0.200847816208423 1.0 0.6292726102260824 7 O75844 1 +Vascular process in circulatory system 0.446689884877505 1.2785698482530474 0.2010485734109277 1.0 0.6292983801886762 25 O15439,Q9HB40,P41440,P08183 4 +Positive regulation of endothelial cell proliferation 0.6242426124562652 1.2753464861474142 0.2021866308259365 1.0 0.6315768995374084 7 P26583,O75340,Q9H2J4,P09601 4 +Nadp metabolic process 0.4915061649783575 1.2715217374299668 0.2035430992536908 1.0 0.6330854373521833 16 P48735 1 +Maternal process involved in female pregnancy 0.6833447718241402 1.2631404126011625 0.2065387227552524 1.0 0.6355037623238536 5 Q9BQE5 1 +Regulation of mitochondrion organization 0.4141148286074726 1.2578129674123064 0.2084594048818653 1.0 0.6387031219424557 37 Q9NUQ9,O75832,Q9UG56,O43464,O14737,Q99536,P21796,P11233,P12235,Q9UII2,Q13501 11 +Positive regulation of mononuclear cell migration 0.6203153567391385 1.2573380857681964 0.2086312384107764 1.0 0.6387031219424557 7 P78536,P05067,Q07021 3 +Positive regulation of viral process 0.4489092925421478 1.2560237910337633 0.2091073444856079 1.0 0.6387031219424557 24 Q08752 1 +Inflammatory cell apoptotic process 0.8176331970218143 1.2530167240747716 0.210199620380826 1.0 0.6409485908971801 3 O75844 1 +Regulation of membrane potential 0.3783843680788576 1.252781478724324 0.210285243864156 1.0 0.6409485908971801 51 Q8IWA4,P05067,Q9BSK2,Q9UQB8,P30626,O75844,P04062,P31751,Q14168,Q9UII2 10 +Positive regulation of vesicle fusion 0.8167055027884939 1.2494215977084095 0.2115109130208103 1.0 0.6426399556009301 3 P04083 1 +Negative regulation of cytokine production 0.4561913143128256 1.2371781996823106 0.2160209330397033 1.0 0.6476214802559089 22 P04062,P04083,Q9Y639,P09601,P31483 5 +Anatomical structure maturation 0.4410261813966485 1.236720789069259 0.2161907579743884 1.0 0.6476214802559089 25 P05067,O94788,P04062,P18074,O75503 5 +Regulated exocytosis 0.4388800077334681 1.23519388373025 0.216758355020854 1.0 0.6476214802559089 26 P11279,P04899,Q9BRK5,O95721,P35080,P51809,Q06787,P09601,O15439,O43760 10 +Regeneration 0.4453204069532183 1.2299740067057003 0.2187068387376423 1.0 0.6498958642662213 24 P00374,Q96G23,P09601 3 +Regulation of inflammatory response 0.4550069595597525 1.228881404802734 0.219116274338722 1.0 0.6504849397236279 22 P28070,P05067,P60900,P04062,P04083 5 +Regulation of histone h4 acetylation 0.7026153677198737 1.2268726700211938 0.2198704520745553 1.0 0.6514680061468306 4 O75844 1 +Positive regulation of response to endoplasmic reticulum stress 0.6742592118389341 1.224538763176755 0.220749052669912 1.0 0.6523155948440064 5 P46379 1 +Cellular response to increased oxygen levels 0.6733404259412907 1.220634874909381 0.2222242957032196 1.0 0.6541633095650127 5 Q9Y487,Q15904 2 +Cellular response to chemical stress 0.3640530617373003 1.2194475382841543 0.2226743761560448 1.0 0.6542452649418433 58 Q9NR28,P04792,Q8IXJ6,P04062,P07237,Q6NUK1,O43464,P00374,P04083,O95831,P09601,Q99720 12 +Mitochondrial electron transport cytochrome c to oxygen 0.6725935611472895 1.2174614808336823 0.2234286834246126 1.0 0.6553908047121971 5 P13073,P00403,P20674 3 +Pyridine nucleotide biosynthetic process 0.80835016648829 1.2170606174243632 0.2235811533191758 1.0 0.655525894548369 3 P43490 1 +Regulation of centriole replication 0.6722239468470154 1.2158910119893984 0.2240264424069371 1.0 0.6557603722554294 5 Q96PK6 1 +Peptide transport 0.4483407110016013 1.21573222192913 0.2240869453892335 1.0 0.6557603722554294 23 P30626,P62820,P04083,Q16836,P40939,O15439 6 +Negative regulation of mrna metabolic process 0.4074362542602863 1.214554418888352 0.2245360824875448 1.0 0.656451005279201 38 Q13242,Q14011,Q99729,Q92804,O00267,P98175,Q92615,Q9Y2W1,Q5VTR2,P38159,O60506,Q13151,Q14103,P26368,P61978,P22626,P35637,O75494,Q06787,Q07021,P07910 21 +Cell killing 0.4739484835968981 1.2138779427838546 0.2247943369310929 1.0 0.6565827953985456 17 P11279,P51809,P07437,P81605,P68371 5 +Cellular response to dsrna 0.6104704414544533 1.212158118287373 0.2254518600083479 1.0 0.6575679250243481 7 Q9NUD5 1 +Cellular response to estradiol stimulus 0.806731127187302 1.2107943206644525 0.2259742423763717 1.0 0.6584679910304873 3 O95831 1 +Mucopolysaccharide metabolic process 0.6099707315479698 1.2098637457134434 0.2263311807349608 1.0 0.658642113867082 7 O43505,P15586,O60701,P16278 4 +Positive regulation of cell junction assembly 0.5702967835694108 1.208570234404699 0.2268279976407419 1.0 0.6593961611453375 8 P60903 1 +Negative regulation of circadian rhythm 0.7471451876019564 1.204292812129701 0.2284764238833068 1.0 0.6604143022712659 2 P23246 1 +Negative regulation of transcription regulatory region dna binding 0.7471451876019457 1.2042928121296554 0.2284764238833243 1.0 0.6604143022712659 2 P30626 1 +Leukotriene metabolic process 0.6970134853386281 1.2036430581276854 0.2287275695443453 1.0 0.6604143022712659 4 O14880,Q14914 2 +Regulation of autophagy 0.35937840374217 1.2029483120347415 0.2289963231104059 1.0 0.6604143022712659 69 P04792,O75844,P04062,P10619,P21796,P09601,Q93050,Q9Y487 8 +Positive regulation of protein secretion 0.4959786260184716 1.2027474891587673 0.2290740507112585 1.0 0.6604143022712659 14 Q08752 1 +Pyrimidine nucleotide metabolic process 0.5028644735944483 1.2013393713257925 0.2296195839311217 1.0 0.6611496043704408 13 Q9H773,P23919,P15531,P04818,P17812 5 +Nitrogen compound transport 0.3316109995679534 1.200853822581771 0.2298079094250438 1.0 0.6611496043704408 439 Q9UJS0,O60830,Q9Y3B3,Q99595,P49755,Q08752,Q658P3,Q6NUQ1,P50897,Q7L5D6,Q10713,A6NIH7,Q9NS69,O43772,Q9BSK2,Q9Y282,Q16850,Q9H2D1,O60725,Q14108,P55786,Q15629,P10619,Q16836,O95831,P43307,P24390,Q14168,O43681,Q99797,Q9Y619,P04792,O95721,P08183,Q8N4H5,P40939,O15439,A0AVF1,Q15904,Q13501,P61020,Q5W0Z9,O00148,O14737,Q9UI26,P41440,O14925,P20290,Q9H2J7,P04083,Q9BW83,Q9UII2,Q9BUN8,P30626,P51809,P22626,Q9BTX1,Q86YV9,Q8TB61,Q99523,Q9HD20,P46379,Q6NUK1,P31751,P61923,Q5JRX3,P37198,Q9Y679,Q8NFH4,Q86V81,O43464,P62820,Q99816,Q7KZ85,P84103,O75340,P18085,Q15041,O15173,Q9Y277,O95140,Q92973,P82979,P40616,Q9H814,Q8N183,Q16630,Q9Y4P1,P09651,O60645,O43808,Q9NR31,L0R6Q1,Q9BZH6,Q15785,P51991,P27348,Q9UBV2,Q9NVZ3,Q8NC96,O14828,Q9HC21,Q8N6T3,Q15388,Q07955,P55011,P12235,Q92688,Q969Q5,Q9ULX6,P61106,Q8WUX9,Q8NFH5,Q06787,P61981,Q92572,Q96CS3,Q9H6R4 118 +Adp transport 0.6962572999012917 1.2005079954083286 0.2299421093249241 1.0 0.6611496043704408 4 P12235,O43808 2 +Adult locomotory behavior 0.4955535014576026 1.200216173171058 0.2300553957019397 1.0 0.6611496043704408 14 P50897,O75844,P05067,O43464 4 +Positive regulation of glucose import 0.7446982055464859 1.1938524607784795 0.2325356862663337 1.0 0.6625438609623568 2 P31751 1 +Positive regulation of glucose transmembrane transport 0.7446982055464859 1.1938524607784795 0.2325356862663337 1.0 0.6625438609623568 2 P31751 1 +Fatty acid alpha oxidation 0.7434747145187645 1.1886347272414168 0.2345834361894998 1.0 0.6634535986770436 2 O43808 1 +Branched chain amino acid biosynthetic process 0.7434747145187455 1.1886347272413362 0.2345834361895316 1.0 0.6634535986770436 2 O15382 1 +Transepithelial transport 0.8009101591211718 1.1882786891007686 0.2347236308428084 1.0 0.6634535986770436 3 P08183 1 +Reactive oxygen species metabolic process 0.4039837735422076 1.1844598635721304 0.2362310752736509 1.0 0.6638610509515008 38 Q8IXJ6,P18085,P42785,Q9BSK2,P00374,P00403,Q15067,Q15120,P04899,P62993,Q9UII2 11 +Neurotransmitter transport 0.4573011226239728 1.1828973012522244 0.2368498513524102 1.0 0.6652964360833775 20 P41440,P50897,O95721 3 +Cellular response to reactive oxygen species 0.4570542032489805 1.1812212550391432 0.2375148396742963 1.0 0.6662529200335453 20 P00374,Q99720,O95831 3 +Positive regulation of mitochondrion organization 0.464853898814434 1.1793600474611674 0.2382548369353361 1.0 0.6671490183160883 18 O14737,P21796,P11233,Q9UII2 4 +B cell homeostasis 0.7406199021207198 1.17646666883851 0.2394084441432666 1.0 0.6673478882038092 2 P49069 1 +Arachidonic acid secretion 0.740619902120704 1.1764666688384422 0.2394084441432937 1.0 0.6673478882038092 2 P04083 1 +Lipid export from cell 0.7406199021207023 1.1764666688384344 0.2394084441432968 1.0 0.6673478882038092 2 O15439 1 +Prostaglandin transport 0.7406199021207023 1.1764666688384344 0.2394084441432968 1.0 0.6673478882038092 2 O15439 1 +Cation transmembrane transport 0.3402680118170701 1.175369846293508 0.2398467817809013 1.0 0.6673478882038092 94 Q9Y619,Q9HD20,Q13423,P21796,Q9UJZ1,P61421,O43772,P05067,P31930,O75947,P78417,O75964,P56134,Q9H2J7,Q8N4V1,Q9HC21,P00403,P20674,Q9UM00,P55011,P12235,Q70HW3,Q9UDW1,P30626,P24539,Q13642 26 +Cholesterol efflux 0.6421901741689933 1.1747670415084397 0.240087929366392 1.0 0.6673478882038092 6 P61916,O15118,Q8WTV0 3 +Polyamine metabolic process 0.740212071778144 1.1747291607767314 0.2401030889768032 1.0 0.6673478882038092 2 P49366 1 +Spermidine metabolic process 0.740212071778144 1.1747291607767314 0.2401030889768032 1.0 0.6673478882038092 2 P49366 1 +Cellular response to exogenous dsrna 0.6618482620786026 1.1718111084380156 0.2412729018084005 1.0 0.6673478882038092 5 Q9NUD5 1 +Glutamate receptor signaling pathway 0.796409628722976 1.1708869046573844 0.2416442395496136 1.0 0.6673478882038092 3 Q92542,P05067 2 +Regulation of vesicle mediated transport 0.3471316833180576 1.1666826960542755 0.24333853337886 1.0 0.6704886958240802 85 P41440,P11279,P05067,P61978,P61020,P51809,Q8WTV0,P04083,P50897,P31751,P11233,P09601,Q99816 13 +Signaling receptor ligand precursor processing 0.7381729200652463 1.1660446830429054 0.2435963800737486 1.0 0.6704886958240802 2 P42892 1 +Pyramidal neuron differentiation 0.7949019330405024 1.1650641045325465 0.2439930453743102 1.0 0.6711687847983336 3 P04062 1 +Centrosome separation 0.6875692315644679 1.1645034784624868 0.2442200345093468 1.0 0.6711687847983336 4 Q9UNZ2,P37198 2 +Fat cell differentiation 0.4545858045123886 1.1644585627291053 0.2442382266335889 1.0 0.6711687847983336 20 Q9NZ08,Q8IXJ6,Q8N4Q0,Q99523,P31751 5 +Diencephalon development 0.6597576386639923 1.1629318473215902 0.2448571548697873 1.0 0.6716927505354201 5 O94788 1 +Icosanoid transport 0.7938592717267001 1.1610383825207222 0.2456262907519644 1.0 0.6722342510947119 3 O15439 1 +Positive regulation of viral life cycle 0.6847105006305292 1.1526640877450176 0.2490482871197867 1.0 0.6773233768908992 4 Q99816,P07237 2 +O glycan processing 0.7915261462618517 1.1520335231951355 0.2493072980589852 1.0 0.6777285772477267 3 Q10472 1 +Vascular endothelial growth factor receptor signaling pathway 0.656739998080718 1.1501177237775044 0.2500953873654614 1.0 0.6795710569789336 5 P04792 1 +Multicellular organism aging 0.5475061155178325 1.146848159169617 0.2514443813049647 1.0 0.6819668119133253 9 O75844 1 +Hydrogen peroxide biosynthetic process 0.7887334547510163 1.141261315004673 0.2537611953975283 1.0 0.6843997213873793 3 P00403 1 +Regulation of protein complex stability 0.654232507554797 1.1394724134850536 0.2545061679900564 1.0 0.6852089138193826 5 Q13501 1 +Protein localization to cell junction 0.454644318918413 1.137471200203665 0.2553413574402561 1.0 0.6871571698698024 19 Q9UQB8,Q14168 2 +Negative regulation of lipase activity 0.7874337005304013 1.1362502735040427 0.255851835642195 1.0 0.6882302653082626 3 P04083,Q99523 2 +Ubiquitin recycling 0.6801378834543608 1.133736458464333 0.2569051116222958 1.0 0.6893241287588211 4 Q16763 1 +Positive regulation of smooth muscle cell proliferation 0.5922516571371882 1.128473053361096 0.2591201908260829 1.0 0.6927866213058468 7 O95140,P09601 2 +Membrane protein ectodomain proteolysis 0.5538033321962755 1.1278312454500687 0.2593911949588547 1.0 0.6932103084366791 8 Q9NZ08,Q92542,O43847,P38159 4 +Membrane raft assembly 0.630416235703104 1.1239029831818643 0.2610541856407473 1.0 0.6964459868111752 6 P60903 1 +Small molecule biosynthetic process 0.3326740370100985 1.122922934093488 0.2614702262944011 1.0 0.6972539367850695 112 Q9H7Z7,O14880,Q15392,Q14739,O15382,Q9NRN7,Q14849,O60701,Q53GQ0,Q16850,Q15185,Q13510,P48449,Q13126,P00374,P04083,Q9UBM7,O94788,P04062,P35270,Q9UBX3 21 +Cellular response to acid chemical 0.5186783774014924 1.1226271353485548 0.2615958858193248 1.0 0.6972717551853277 11 Q9UQB8,Q99729,Q14103,Q9Y2Q5 4 +Axoneme assembly 0.7837631963704589 1.1221080804986605 0.2618164885947505 1.0 0.6972717551853277 3 A0AVF1 1 +Regulation of erbb signaling pathway 0.5322205528399491 1.121256651565938 0.2621786315454681 1.0 0.6975312692699748 10 Q9NQC3,Q92600,P78536,Q99816,P37198 5 +Positive regulation of interleukin 2 production 0.6297346669033024 1.1209593896637169 0.2623051490440411 1.0 0.6975312692699748 6 P04083 1 +Acidic amino acid transport 0.5414031314176432 1.1161954685586224 0.2643384737573857 1.0 0.6988901631530403 9 Q9UJS0,O14745,Q15041,Q15042,P55011 5 +Tricarboxylic acid cycle 0.4383983929347483 1.1121412965509998 0.2660774032618149 1.0 0.6989166160342396 22 P48735 1 +Regulation of tor signaling 0.5166385752291507 1.1116966377393818 0.2662686059437122 1.0 0.6989166160342396 11 O75340,P04062,Q9Y2Q5,O75844 4 +Corticosteroid receptor signaling pathway 0.647611269906077 1.11137639466889 0.2664063685883149 1.0 0.6989166160342396 5 Q15185,O14497,P27797,Q04917 4 +Energy homeostasis 0.626786488890083 1.1082283361240968 0.2677632161309828 1.0 0.6989166160342396 6 P42785 1 +Regulation of peptidyl lysine acetylation 0.4865222493524614 1.1063219555266532 0.2685871920503793 1.0 0.6989166160342396 13 Q03164,O75844 2 +Mammary gland development 0.4797971543581933 1.1062289227925826 0.2686274471777672 1.0 0.6989166160342396 14 P31751,P00403,Q13505 3 +Cellular response to vitamin 0.7796091864023896 1.1061199828763992 0.2686745905857577 1.0 0.6989166160342396 3 Q96C86 1 +Calcium ion import 0.5384590865891703 1.1014062450104471 0.27071988866523 1.0 0.7006867706629483 9 P21796 1 +Positive regulation of chemotaxis 0.5282752486320124 1.1009195410312511 0.2709316764765921 1.0 0.7009404145719477 10 P04792,Q9ULM6,P78536,Q07021 4 +Response to increased oxygen levels 0.5858309179096621 1.09897924381411 0.2717771195121286 1.0 0.7016993871328667 7 Q9Y487,Q15904 2 +Protein peptidyl prolyl isomerization 0.4408343081600811 1.0989391689992063 0.2717946002758149 1.0 0.7016993871328667 21 Q9Y680,Q08752 2 +Retrograde vesicle mediated transport golgi to endoplasmic reticulum 0.4486455544482832 1.097308370101396 0.2725066131967513 1.0 0.7028293697309103 19 P61923,Q9Y282,P24390 3 +Protein hydroxylation 0.4631188325375989 1.0930932034949763 0.2743528797690553 1.0 0.7037337765559916 16 O75718,O15460,P13674,Q92791 4 +Trna transport 0.6697402373611009 1.090752638789258 0.2753817415106101 1.0 0.7047004501124577 4 Q15388 1 +Organelle fusion 0.4110742285903866 1.089084680780759 0.2761165447298976 1.0 0.7051245182748379 30 Q9UNK0,Q8IWA4,P08754,O95140,O60313,O95721,Q86Y82,Q9NX63,P51809,P31751,Q99536,P04083,Q9UJZ1,Q9Y3E7,Q9P253 15 +Negative regulation of immune system process 0.405923051760399 1.0886153864429609 0.2763235287533154 1.0 0.7051245182748379 32 P28070,Q9UIV1,Q7Z739,P04083,P09601,Q96J02 6 +Mitochondrial atp synthesis coupled proton transport 0.5258873158558744 1.0886088917311911 0.2763263940122498 1.0 0.7051245182748379 10 O75947,O75964,P56134,P24539,Q9UJZ1 5 +Positive regulation of mitochondrial membrane potential 0.6689478584919684 1.0874806779297028 0.2768244332599843 1.0 0.7061029022283658 4 Q8IWA4,P31751 2 +Dna methylation 0.4693165109810051 1.085495516277042 0.2777022484759655 1.0 0.7073286144693472 15 Q03164,O75844 2 +Regulation of short term neuronal synaptic plasticity 0.7190048939641104 1.0847002371899763 0.2780544427918154 1.0 0.7077749452882576 2 Q15042 1 +Biological process involved in symbiotic interaction 0.350260365068879 1.0808732521781956 0.2797534982355936 1.0 0.7103386435001058 64 Q14108,P11279,O15118,Q13573,Q12899,Q8WUX9,Q86V81,Q08752,Q8WTV0,P07237,P81605,Q9BTY2,Q99816,Q96J02 14 +Protein targeting to lysosome 0.5438061040380591 1.0788684129979171 0.280646391719503 1.0 0.7106919662237244 8 Q14108 1 +Mitochondrial transcription 0.6666032605749984 1.0778026669719276 0.2811218291152417 1.0 0.7106919662237244 4 Q9BSK2 1 +Amino acid transmembrane transport 0.5099517514764581 1.0758548404585713 0.2819921813624457 1.0 0.7106919662237244 11 Q9Y619,Q9H2J7,Q15041 3 +Myeloid cell development 0.5233867440361374 1.075717060336963 0.2820538151386167 1.0 0.7106919662237244 10 Q9NYL9,Q15904,P05067 3 +Mitochondrial outer membrane permeabilization involved in programmed cell death 0.523232381418181 1.074921232270588 0.2824099951253405 1.0 0.7106919662237244 10 P45880 1 +Amino acid transport 0.4744713786887535 1.0744032060993782 0.2826420061686416 1.0 0.7106919662237244 14 Q9Y619,Q9H2J7,P55011,Q15041 4 +Dephosphorylation of rna polymerase ii c terminal domain 0.7165579119086455 1.0743595211532833 0.2826615774753449 1.0 0.7106919662237244 2 Q96P16 1 +N terminal protein amino acid modification 0.5426971150992667 1.0734376552757894 0.283074797131956 1.0 0.71086047710267 8 Q9BV86 1 +C4 dicarboxylate transport 0.6183291048603198 1.0717270619328323 0.2838426420485196 1.0 0.7111413936583981 6 Q02978,Q9UBX3,P55011 3 +Negative regulation of gliogenesis 0.7705288964013087 1.0712414702245932 0.2840608694285536 1.0 0.7111413936583981 3 Q96G23 1 +Sarcoplasmic reticulum calcium ion transport 0.6175965874676294 1.0685673379338745 0.2852646726834256 1.0 0.7111413936583981 6 P30626,O75844,P78417 3 +Positive regulation of toll like receptor signaling pathway 0.6370178495007794 1.0664815695829504 0.2862060057466074 1.0 0.7123871267538436 5 P41440 1 +Lymphocyte migration 0.5214549152858452 1.065757441653025 0.2865333038300328 1.0 0.7127201308040126 10 P55011,P04062,P05067 3 +Regulation of lipoprotein particle clearance 0.6166874973434463 1.0646464203643564 0.2870359648511025 1.0 0.7127201308040126 6 Q9Y2B0,Q92945,P30533,P61978 4 +Sprouting angiogenesis 0.5212312667569791 1.0646044289410208 0.2870549747605122 1.0 0.7127201308040126 10 P09601 1 +Late endosome to vacuole transport 0.7141109298531847 1.064030147362307 0.2873150426825583 1.0 0.712958800833956 2 Q8WUX9 1 +Protein localization to presynapse 0.7679427279183293 1.0613269962477687 0.2885413211972421 1.0 0.7141078901466498 3 Q14168 1 +Protein transport along microtubule 0.7679427279183293 1.0613269962477687 0.2885413211972421 1.0 0.7141078901466498 3 Q14168 1 +Axo dendritic protein transport 0.7679427279183293 1.0613269962477687 0.2885413211972421 1.0 0.7141078901466498 3 Q14168 1 +Activation of phospholipase d activity 0.7678155842383836 1.0608398075472447 0.2887627079488137 1.0 0.7142212618305067 3 P18085 1 +Photoreceptor cell development 0.6619172314707498 1.0584765590890457 0.2898382320525479 1.0 0.7158795146125481 4 Q15555,Q8NBN7 2 +Actin cytoskeleton reorganization 0.4427448100610208 1.057748166725494 0.2901702694573584 1.0 0.7160443257315964 19 Q9UQB8,P04083,P11233 3 +Regulation of autophagy of mitochondrion in response to mitochondrial depolarization 0.5766146209736486 1.0566653114367794 0.2906643617000419 1.0 0.7164835806611678 7 P04062,Q9UII2,O43464 3 +Mitochondrial outer membrane permeabilization 0.529134132461403 1.0545640951363635 0.2916247321680627 1.0 0.7172027479996553 9 P45880 1 +Regulation of lipid metabolic process 0.3891279043745991 1.0543974910564753 0.2917009704706128 1.0 0.7172027479996553 38 P61916,Q96G23,O75874,O75844,Q8WTV0,Q15120,Q13510,Q9UBM7 8 +Membrane biogenesis 0.44868596570214 1.05019761308555 0.2936272667394317 1.0 0.7192137397061138 17 P60903,P41440,Q8IXJ6,Q9UNZ2,Q86XL3 5 +Long term synaptic potentiation 0.5279262581061365 1.0484977385796197 0.2944093436559458 1.0 0.7192137397061138 9 Q14168,P05067,Q13501 3 +Regulation of dna damage response signal transduction by p53 class mediator 0.5373339728828666 1.047179370026187 0.2950168582167383 1.0 0.7192137397061138 8 O75844 1 +Regulation of mitochondrial membrane potential 0.4482146205185128 1.047135398345391 0.2950371351746308 1.0 0.7192137397061138 17 Q8IWA4,Q8N0X7,Q9BSK2,P31751,Q9UII2 5 +Regulation of chemotaxis 0.4557948579376026 1.0468711665697674 0.2951590018188663 1.0 0.7192137397061138 16 Q9NUQ9,P04792,Q9BVA1,Q99538,P78536,Q07021,Q9ULM6 7 +Regulation of nik nf kappab signaling 0.4698360087590275 1.0466890308935697 0.2952430244552166 1.0 0.7192137397061138 14 O43657 1 +Cation transport 0.3306238626709607 1.038225576034424 0.2991650481036072 1.0 0.7211934698737191 119 Q9Y619,Q9HD20,Q658P3,Q13423,P21796,O43808,Q9UJZ1,P36542,P61421,O43772,P05067,Q04917,P31930,O75947,P78417,O75964,P56134,O75844,Q8N4V1,Q9H2J7,O15173,Q9HC21,P00403,P20674,Q9UM00,P55011,P12235,Q70HW3,P04899,Q9UDW1,P30626,P51809,P24539,Q06787,P13693,Q13642 36 +Cellular response to hydrogen peroxide 0.468284699088884 1.0374119969702058 0.2995438895782216 1.0 0.7211934698737191 14 Q99720,O95831 2 +Positive regulation of membrane potential 0.6300926516444902 1.037182948721731 0.2996506031448174 1.0 0.7211934698737191 5 Q8IWA4,P31751 2 +Regulation of binding 0.3448641343566835 1.036476719907792 0.2999797947211899 1.0 0.7211934698737191 69 P60903,P41440,Q8IXJ6,P05067,Q9BUN8,P30626,O75844,P18074,P15531,P09601,O75503 11 +Positive regulation of cold induced thermogenesis 0.4882127719806785 1.0328742550389314 0.3016627482459122 1.0 0.72161336933813 12 Q16836,P40939,P23786 3 +Mannosylation 0.6553732507745469 1.0315299284603674 0.3022923808963305 1.0 0.72161336933813 4 Q6ZXV5,O75340 2 +Neuron projection regeneration 0.5340456027866415 1.0310852730739757 0.3025008332579579 1.0 0.72161336933813 8 Q96G23 1 +Regulation of fatty acid biosynthetic process 0.6286189961859546 1.0309545320587683 0.3025621422187083 1.0 0.72161336933813 5 P04083 1 +Negative regulation of bmp signaling pathway 0.6551726202628139 1.0307046227377854 0.3026793562949867 1.0 0.72161336933813 4 Q8N0X7 1 +Organophosphate catabolic process 0.4115852616936987 1.0297549242869464 0.3031250653831834 1.0 0.7217167027842953 26 O75874,Q9H773,Q8WTV0 3 +Regulation of gliogenesis 0.5232749418100229 1.025142405925317 0.3052959989869361 1.0 0.7219192277944421 9 Q96G23 1 +Regulation of dna dependent dna replication 0.4413556071139085 1.0245111343788271 0.3055939144623854 1.0 0.7219192277944421 18 Q9UNS1,O75844,P35250 3 +Cell activation involved in immune response 0.402847090600372 1.023782793150317 0.305937879427161 1.0 0.7219192277944421 30 P11279,P05067,O96028,P51809,P04083,P09601,Q9UQ84 7 +Regulation of platelet activation 0.7043230016313242 1.0228355239952451 0.306385618709333 1.0 0.7225633274308926 2 Q9BWH2 1 +Regulation of vesicle fusion 0.6531287103016916 1.0222999324992628 0.3066389651808736 1.0 0.7228840510961277 4 P04083 1 +Autophagosome maturation 0.4992960015073251 1.0187329236417004 0.308329777657689 1.0 0.7249280268592992 11 Q96AX1,O95721,Q8WUX9,P51809,Q99816,Q9NRR5,Q9Y3E7 7 +Receptor mediated endocytosis 0.3799144580340311 1.01697272448403 0.3091664049703382 1.0 0.7256124746109518 41 Q14108,P50897,Q5VW38,P05067 4 +Negative regulation of small gtpase mediated signal transduction 0.521539353049865 1.0164302797380151 0.3094245325364797 1.0 0.7256124746109518 9 O95140,P37198 2 +Camera type eye development 0.4156615917961042 1.013353300651208 0.3108914368718758 1.0 0.7256124746109518 24 O95140,O94788,O96019,Q15293,P54802,Q15555,Q8NBN7,Q99797 8 +Neuromuscular process 0.4284076910182784 1.012712579275667 0.3111974675860272 1.0 0.7256124746109518 21 P04062,P17900,P10253,O75844 4 +Histone h4 acetylation 0.4502915826636276 1.012114348581128 0.3114833825944005 1.0 0.7256124746109518 16 Q03164,Q86UY6,O75844,O96019 4 +Positive regulation of cysteine type endopeptidase activity 0.423872631710933 1.0095809970578302 0.3126960777491072 1.0 0.7256124746109518 22 O75340,Q9NR28,O43464,O14737,O95831,Q92688 6 +Regulation of defense response to virus 0.4698191924183585 1.0090145851481809 0.3129676394033718 1.0 0.7256124746109518 13 O43657,O75844,Q96ST3,Q07021,Q96J02,O60828 6 +Neuron projection guidance 0.4416941171590439 1.004756377220195 0.3150141738919478 1.0 0.7277826771184079 17 Q9BVA1,Q9Y639,P05067 3 +Epithelial cell proliferation 0.4043531942938308 1.0023302561567131 0.3161841142443355 1.0 0.7278840063177059 28 O94788,Q9H2J4,Q8WTV0,P15531,P09601,Q9UII2 6 +Regulation of excretion 0.6994290375203871 1.002318798035079 0.3161896464147036 1.0 0.7278840063177059 2 P04899 1 +Extracellular transport 0.6994290375203818 1.002318798035057 0.3161896464147142 1.0 0.7278840063177059 2 Q99816 1 +Nucleobase transport 0.7524074853756219 1.0019800001819377 0.3163532523273542 1.0 0.7279551865283908 3 Q9Y277 1 +Nuclear membrane reassembly 0.5645215859275389 1.0012187359165128 0.3167210704406802 1.0 0.7285294226716169 7 Q8IXJ6,Q9UNZ2,Q86XL3 3 +Histone h4 k20 methylation 0.6472567939772322 0.9981870444685886 0.3181886675006462 1.0 0.730030570475877 4 O96028 1 +Carbohydrate metabolic process 0.3235821534247949 0.9979125383239718 0.3183217714769815 1.0 0.730030570475877 112 P06280,P31751,P16278,Q15120,P48735,P05067,O75874,O60701,Q9BTY2,Q15185,Q99519,Q14108,P30837,O75844,Q9NUJ1,P17900,P85037,Q86W56,P10253,Q9UBX3 20 +Synaptonemal complex organization 0.6204697102491762 0.9965572560264138 0.3189794623191311 1.0 0.7311339350185195 5 Q92791 1 +Regulation of fatty acid metabolic process 0.5175539824268678 0.9964320593642394 0.3190402625535358 1.0 0.7311339350185195 9 P04083,Q15120 2 +Leukocyte mediated immunity 0.3810003030051915 0.9961711295851786 0.3191670043019567 1.0 0.7311523787653602 39 P11279,O96028,P07437,P09601,Q9UQ84,P68371 6 +Extrinsic apoptotic signaling pathway via death domain receptors 0.4950020374532536 0.9957223762001224 0.3193850549056889 1.0 0.7313799026836594 11 Q9NR28,P09601 2 +Response to hydroxyurea 0.6464312252051784 0.9948010090408044 0.3198330554011406 1.0 0.7318011605702447 4 Q9UNS1 1 +Regulation of protein adp ribosylation 0.6200080538244234 0.99461117568031 0.3199254099700761 1.0 0.7318011605702447 5 Q15397,Q9NWY4,P18887 3 +Positive regulation of erbb signaling pathway 0.6191131058705572 0.9908394157256706 0.3217639992950993 1.0 0.7327233548077408 5 Q9NQC3,Q92600,P37198 3 +Negative regulation of mrna catabolic process 0.4251760923612345 0.990260264990608 0.3220469229058591 1.0 0.7327233548077408 21 Q14011,Q99729,Q92804,O60506,P35637,Q06787,Q14103,Q13151,Q9Y2W1 9 +Cellular modified amino acid catabolic process 0.6188980935080042 0.989933410936438 0.3222066675436978 1.0 0.7327233548077408 5 Q9UHG3 1 +Vacuolar localization 0.4804254002030306 0.9893955615333953 0.3224696452733417 1.0 0.7327233548077408 12 P51809,P09601 2 +Adult behavior 0.4392548703891779 0.988897038425852 0.3227135196854289 1.0 0.7330071096099714 17 P50897,O75844,P05067,O43464 4 +Response to light stimulus 0.3781649309318189 0.9852828659478786 0.3244851465598379 1.0 0.7349916701342817 40 Q14011,P05067,Q08752,P18074,P31751,Q15555,Q9Y639,Q8NBN7 8 +Regulation of reactive oxygen species metabolic process 0.4001313630414339 0.985103508581444 0.3245732301379735 1.0 0.7349916701342817 29 Q8IXJ6,P18085,P42785,Q9BSK2,P00374,P00403,Q15120,P62993 8 +Activation of cysteine type endopeptidase activity involved in apoptotic process 0.492876129431178 0.984333564898405 0.324951531344726 1.0 0.7349916701342817 11 O75340,Q9NR28,O95831,Q92688 4 +Cardiolipin metabolic process 0.6171845286379258 0.9827152434224088 0.325747606248908 1.0 0.7357169991346616 5 P40939 1 +Membrane protein intracellular domain proteolysis 0.6933115823817331 0.9767565959169984 0.3286896687858491 1.0 0.7384004040719919 2 Q92542 1 +Regulation of low density lipoprotein particle clearance 0.6149448754593636 0.9732874615901465 0.330410452325915 1.0 0.7398963994103864 5 Q9Y2B0,P07355,Q92945,P61978 4 +Inner mitochondrial membrane organization 0.4438364139242577 0.9713333734375522 0.3313822948802134 1.0 0.7398963994103864 16 Q13505,Q9NX63,Q5XKP0 3 +Regulation of peptidyl threonine phosphorylation 0.5950004336323211 0.9713140586813762 0.3313919100605935 1.0 0.7398963994103864 6 P05067 1 +Coenzyme a biosynthetic process 0.6399758164624569 0.968362815188764 0.3328632035422321 1.0 0.7410326468450126 4 Q9NVE7 1 +Ameboidal type cell migration 0.3412004113258939 0.9676406149952606 0.3332238857870839 1.0 0.7412977603347812 57 P07737,P04792,P42785,Q8WTV0,P04083,P09601 6 +Mitochondrial fusion 0.4896486715385783 0.9670494516543644 0.3335193130919693 1.0 0.7412977603347812 11 Q8IWA4,O95140,Q9NX63,Q9UJZ1 4 +Regulation of insulin secretion involved in cellular response to glucose stimulus 0.6131798997796896 0.9658632079946748 0.3341126347813783 1.0 0.7412977603347812 5 P30626 1 +Insulin secretion involved in cellular response to glucose stimulus 0.6131798997796896 0.9658632079946748 0.3341126347813783 1.0 0.7412977603347812 5 P30626 1 +Negative regulation of ion transmembrane transporter activity 0.5201709997957342 0.9632646165500572 0.3354147452734075 1.0 0.7419985966634524 8 O14745,P30626,P62258,Q06787,P78417 5 +Regulation of mitotic cytokinesis 0.6900489396410953 0.9631641072395852 0.3354651743567234 1.0 0.7419985966634524 2 P37198 1 +Cellular homeostasis 0.317781140785292 0.9600196065768944 0.3370453472582952 1.0 0.7441574692154476 107 P61421,P85037,P13693,P05067,Q9HD20,P30626,P10253,Q16763,P50897,P09601,Q15120,O75503,Q9Y487,Q93050,Q15904 15 +Intrinsic apoptotic signaling pathway in response to oxidative stress 0.4748618966502237 0.9583497307455442 0.3378864346544727 1.0 0.7454800993809285 12 Q9NR28,P04792,P07237 3 +Retina development in camera type eye 0.4746896057560785 0.9573886445211398 0.3383711278394408 1.0 0.7455754026315812 12 P54802,Q15555,Q8NBN7,O96019 4 +Determination of adult lifespan 0.5914367604923801 0.9560269351276686 0.3390586264714288 1.0 0.7456049479218668 6 O75844 1 +Regulation of cytoplasmic mrna processing body assembly 0.6880097879282259 0.9546839475900666 0.3397375500342696 1.0 0.7460903059576117 2 Q9ULM6 1 +Regulation of toll like receptor signaling pathway 0.5183516591727972 0.9543854600530322 0.3398885634345729 1.0 0.7461559339832392 8 P41440,Q9NPR9 2 +Plasminogen activation 0.6100427324603466 0.9526792428025052 0.3407526135133338 1.0 0.7462220947580669 5 Q15392 1 +Response to potassium ion 0.7388428314766314 0.9505068130556298 0.3418547937191982 1.0 0.7464528906002645 3 Q14168 1 +Cellular response to potassium ion 0.7388428314766314 0.9505068130556298 0.3418547937191982 1.0 0.7464528906002645 3 Q14168 1 +Regulation of alcohol biosynthetic process 0.7388379429408647 0.9504883293106005 0.3418641812052356 1.0 0.7464528906002645 3 Q9UBM7 1 +Regulation of cholesterol biosynthetic process 0.7388379429408647 0.9504883293106005 0.3418641812052356 1.0 0.7464528906002645 3 Q9UBM7 1 +Establishment of protein localization to mitochondrial membrane 0.4982224384299246 0.9460952020312204 0.3441000307552906 1.0 0.7487305508486719 10 Q9NS69 1 +Mitotic nuclear membrane organization 0.634398262249751 0.9455792986257447 0.3443632070536049 1.0 0.7487742165373125 4 Q86XL3 1 +Response to steroid hormone 0.3389667004576165 0.9437789773608432 0.3452826056019047 1.0 0.7499791433384108 58 O75874,P04062,O15173,P04083,P16278,Q13185,O95831,Q15185 8 +Negative regulation of intracellular estrogen receptor signaling pathway 0.6075825355983382 0.9423518608500242 0.3460125247026762 1.0 0.7510099676700446 5 Q92600,Q9P253 2 +Mitochondrial electron transport nadh to ubiquinone 0.4389482248697762 0.9404535917959594 0.3469849437298249 1.0 0.7515841819247194 16 Q9Y375,O43676 2 +Regulation of translational initiation in response to stress 0.6069540230162718 0.9397152058059622 0.3473636633018955 1.0 0.7515841819247194 5 P19525,Q13217 2 +Response to ketone 0.3921853010420262 0.938970707910918 0.3477457838287305 1.0 0.7520945479064769 30 P04062,Q13126,O95831,P16278 4 +Myotube differentiation 0.4514479222021341 0.9367301062294872 0.34889740580949 1.0 0.7530511632047858 14 P41440,Q8IV08 2 +Cellular aldehyde metabolic process 0.4246619672461454 0.9363249835937998 0.349105888610935 1.0 0.7532372237629982 19 P48735,O75874 2 +Regulation of mrna catabolic process 0.3375265864565733 0.9299210961891738 0.3524119393128013 1.0 0.7539705654945833 60 Q14011,Q9Y2L1,Q99729,Q7Z739,Q92804,P08670,Q9ULM6,Q15024,Q9UIV1,Q969T7,Q96C86,Q9Y2W1,O60506,Q9Y5S9,Q13151,Q14103,Q9NQT5,P35637,Q06787 19 +Negative regulation of mrna splicing via spliceosome 0.4502460862087901 0.92954799650536 0.3526051635018397 1.0 0.7539705654945833 14 Q13242,P98175,P61978,P38159,P22626,O75494,Q07021 7 +Striated muscle cell proliferation 0.6304346484061505 0.9294253077236108 0.3526687173054625 1.0 0.7539705654945833 4 Q12948,P10644 2 +Regulation of t cell migration 0.6298426636096373 0.9270154117284009 0.3539185324885028 1.0 0.75436131489835 4 P05067 1 +Dendritic cell migration 0.6293877551020373 0.9251640409642484 0.3548805850950201 1.0 0.7544655543854794 4 P60953,Q07021,P27797 3 +Leukocyte migration 0.3833428204935545 0.9246164330703538 0.3551654620012583 1.0 0.7544655543854794 33 P04062,P05067,P09601 3 +Substantia nigra development 0.429175452380196 0.923358290236966 0.355820520332061 1.0 0.7547708007043719 17 Q8IXJ6,P00367,Q04917,Q9UQR1,P80723,P24539,P27348,O15027 8 +Gland development 0.3492930443411567 0.9226715142296704 0.3561784149514924 1.0 0.7552698919453332 50 O94788,O75844,P31751,P15531,P04083,P00403,P09601,Q13505 8 +Dicarboxylic acid metabolic process 0.3737770447566029 0.9192921303113823 0.35794279298059 1.0 0.7566669885931485 38 P48735,O75874,Q9H2D1 3 +Protein localization to extracellular region 0.3634927823374171 0.9189726781435276 0.3581098631686126 1.0 0.7567604655638606 44 P30626,Q08752,P04083,Q16836,Q16850,P40939 6 +Centriole assembly 0.5825689779682341 0.9180680745331692 0.3585832276423253 1.0 0.7568986704594213 6 Q96PK6 1 +Negative regulation of transporter activity 0.5015729085219095 0.9163920012872916 0.359461329098278 1.0 0.7571742316766106 9 O14745,P30626,P62258,Q06787,P78417 5 +Negative regulation of protein polymerization 0.4094632594732413 0.9076404533781622 0.3640682139878919 1.0 0.7612841552874454 22 P45880,Q9NYL9 2 +Regulation of carbohydrate catabolic process 0.4656783720268621 0.9071622922481588 0.3643209809049716 1.0 0.7612841552874454 12 Q14108 1 +Alternative mrna splicing via spliceosome 0.3722404550746722 0.905744995426458 0.3650708406765972 1.0 0.7612841552874454 38 Q13242,P62995,Q9UHX1,P98175,P38159,Q96I25,P09651,P23246,Q8IY67,Q9Y5S9,Q06787,Q07955,Q9BWF3,P31483,Q9Y2W1 15 +Negative regulation of amyloid fibril formation 0.6245962828708637 0.9056913889468148 0.3650992215621638 1.0 0.7612841552874454 4 Q99471 1 +Neurotransmitter secretion 0.440015193867117 0.9055280552679006 0.365185703828633 1.0 0.7612841552874454 15 P50897 1 +Locomotory behavior 0.394724499343786 0.9021413073474156 0.3669818083047631 1.0 0.761763217244443 26 O15118,P05067,O75844,O43464,P50897,P10253 6 +Positive regulation of amino acid transport 0.6236093599734855 0.9016869668518944 0.3672231782979072 1.0 0.761763217244443 4 P55011,Q15041 2 +Positive regulation of amine transport 0.6236093599734855 0.9016869668518944 0.3672231782979072 1.0 0.761763217244443 4 P55011,Q15041 2 +Mitochondrial electron transport ubiquinol to cytochrome c 0.725747162971264 0.9011850557268618 0.3674899353338599 1.0 0.761763217244443 3 Q9UDW1 1 +Negative regulation of retinoic acid receptor signaling pathway 0.674959216965744 0.9007104440875848 0.3677422941856618 1.0 0.761763217244443 2 A5YKK6 1 +Regulation of dendritic cell chemotaxis 0.6749592169657439 0.9007104440875827 0.3677422941856629 1.0 0.761763217244443 2 Q07021 1 +Neuron recognition 0.5782840321275785 0.8997734510302291 0.3682408256628022 1.0 0.761763217244443 6 Q9Y639,P05067 2 +Rna phosphodiester bond hydrolysis exonucleolytic 0.4255259147660027 0.8996366399396273 0.3683136518158845 1.0 0.761763217244443 17 Q15024,Q9NQT5,Q9Y2L1,Q9UIV1,Q96GM8,Q96C86 6 +Positive regulation of pattern recognition receptor signaling pathway 0.5065927528484635 0.8971084880656772 0.3696610298611991 1.0 0.7627453212530545 8 Q9NUD5 1 +Cellular ketone metabolic process 0.3940454554297267 0.8969984945300752 0.3697197203545712 1.0 0.7627453212530545 26 P04083,Q14849,Q06136,Q15120 4 +Cellular response to corticosteroid stimulus 0.4764294386931773 0.8963661606927303 0.3700572341970076 1.0 0.7627453212530545 11 P04083,O95831 2 +Negative regulation of autophagy 0.4078244398597084 0.8960451414781564 0.3702286543095183 1.0 0.7627453212530545 22 P85037,P10619,Q8IXJ6,P09601 4 +Vitamin metabolic process 0.4035095662757064 0.893637280341883 0.3715159930054208 1.0 0.7640224843461324 23 P41440,Q96EY8,Q9NRN7,O94788,Q8NFF5,P04062,P00374,P78417,Q9H2D1 9 +Insulin secretion 0.4245652737849929 0.8933942140082639 0.3716461000895665 1.0 0.7640224843461324 17 P04083,Q16836,P40939 3 +Lymphocyte mediated immunity 0.3863940302828208 0.8928558774490193 0.371934358233172 1.0 0.7640224843461324 30 P11279,O96028,P51809,P07437,Q9UQ84,P68371 6 +Gene silencing by rna 0.3731658798032561 0.892798961450112 0.3719648426224109 1.0 0.7640224843461324 36 Q9H9A5,Q92600,Q9UIV1,O75844,P22626,Q01085,Q06787,Q9ULM6,Q9BWF3,Q15631,Q8WYQ5,Q8IWR0 12 +Exit from mitosis 0.4750938662733811 0.8892379883198945 0.3738751906442941 1.0 0.7643780864151515 11 Q16763,Q8IXJ6,Q8WUX9 3 +Regulation of myeloid leukocyte mediated immunity 0.5754954463615044 0.8878860547658234 0.374602046734152 1.0 0.7646015428119705 6 P09601 1 +Immune effector process 0.333949090750406 0.8877228363364684 0.3746898588637548 1.0 0.7646015428119705 57 P11279,P05067,O96028,P07437,P04083,P09601,Q9UQ84,P68371 8 +Regulation of alternative mrna splicing via spliceosome 0.3895707869527536 0.8876496636898163 0.3747292301541134 1.0 0.7646015428119705 28 P62995,Q9UHX1,P98175,P38159,P09651,Q8IY67,Q9Y5S9,Q06787,Q9BWF3,P31483,Q9Y2W1 11 +Positive regulation of carbohydrate metabolic process 0.5936166513366292 0.8839462050317094 0.3767252531314291 1.0 0.7666427351468792 5 P05067 1 +Interleukin 2 production 0.5385186250737108 0.8825611901146524 0.3774734052105528 1.0 0.7671845313769138 7 P04083 1 +Phagolysosome assembly 0.6704730831973915 0.8822871840634258 0.3776215251896013 1.0 0.7671845313769138 2 P61106 1 +Phagosome maturation 0.6704730831973915 0.8822871840634258 0.3776215251896013 1.0 0.7671845313769138 2 P61106 1 +Positive regulation of synaptic transmission 0.4226659248000775 0.8810544290432989 0.3782883609138421 1.0 0.7675416018541723 17 Q14168,P41440,P05067,Q13501 4 +Positive regulation of membrane permeability 0.472379604455559 0.8747608706509635 0.3817040319863283 1.0 0.7711698383193777 11 P45880 1 +Substrate dependent cell migration 0.6167346938775473 0.873858507124603 0.382195313536193 1.0 0.7712389596932561 4 Q14247,Q9Y5K6,P06576 3 +Intracellular sterol transport 0.5909177518345926 0.8727078690392246 0.382822327490024 1.0 0.7716575711186348 5 P61916 1 +Regulation of regulated secretory pathway 0.434443228173437 0.8713510770648856 0.3835624896356635 1.0 0.7720413975926232 15 P11279,P51809,P35080,P09601,P04899 5 +Negative regulation of synapse organization 0.6676182707993492 0.87060097585686 0.3839720634590033 1.0 0.7720413975926232 2 O00264 1 +Branching morphogenesis of a nerve 0.6676182707993469 0.8706009758568507 0.3839720634590085 1.0 0.7720413975926232 2 Q9NQC3 1 +Learning 0.4205734578914244 0.8674645210997559 0.3856875430593387 1.0 0.7720413975926232 17 P50897,Q9Y639,P05067 3 +Positive regulation of secretion 0.3811024261473855 0.8674621965317505 0.3856888162123701 1.0 0.7720413975926232 31 P11279,P30626,P51809,Q08752,Q99816 5 +Positive regulation of lymphocyte migration 0.7165575593781903 0.8668284208540908 0.3860360274056971 1.0 0.7720413975926232 3 P05067 1 +Positive regulation of t cell migration 0.7165575593781903 0.8668284208540908 0.3860360274056971 1.0 0.7720413975926232 3 P05067 1 +Regulation of spontaneous synaptic transmission 0.7165166215297438 0.8666758808408533 0.3861196242644895 1.0 0.7720413975926232 3 P05067 1 +Spontaneous synaptic transmission 0.7165166215297438 0.8666758808408533 0.3861196242644895 1.0 0.7720413975926232 3 P05067 1 +Endomembrane system organization 0.3199381304541012 0.8665143706959734 0.3862081490918985 1.0 0.7720413975926232 122 Q9NQC3,O95197,Q9Y3B3,O95721,Q86XL3,P49755,P46379,P31751,Q13501,Q8IXJ6,P57088,P61020,P62820,Q6IAA8,Q99816,Q14108,P41440,Q9UQB8,O75844,Q8N4V1,Q15041,Q15629,O43760,Q9UNZ2,P49069,Q9ULX6,Q9H8Y8,Q8WUX9,P40616,O43681 30 +Inorganic ion transmembrane transport 0.3209458587504341 0.8651667499553841 0.3869472722725406 1.0 0.7724969899895437 88 Q9HD20,Q13423,P21796,Q9UJZ1,P61421,P31930,O75947,Q02978,P78417,Q9UHG3,O75964,P56134,Q9H2J7,Q8N4V1,P00403,P20674,Q9UM00,P55011,P12235,Q9UDW1,P30626,P24539,Q13642,Q9UBX3 24 +Amine transport 0.5885562145066431 0.8628886979153886 0.3881986652940861 1.0 0.7724969899895437 5 P55011,Q15041 2 +Regulation of amino acid transport 0.5885562145066431 0.8628886979153886 0.3881986652940861 1.0 0.7724969899895437 5 P55011,Q15041 2 +Membrane depolarization during action potential 0.6655791190864635 0.8622723156359513 0.388537683371791 1.0 0.7724969899895437 2 Q04917 1 +Positive regulation of homotypic cell cell adhesion 0.6655791190864633 0.8622723156359505 0.3885376833717915 1.0 0.7724969899895437 2 Q9Y624 1 +Magnesium ion homeostasis 0.6655791190864632 0.8622723156359501 0.3885376833717917 1.0 0.7724969899895437 2 Q6P4Q7 1 +Regulation of peptidyl tyrosine phosphorylation 0.4066818362453821 0.8617235867461105 0.3888396428723624 1.0 0.7724969899895437 21 Q9UIV1,Q9H2J4,P05067 3 +Vascular associated smooth muscle cell proliferation 0.4809965239518428 0.8577393047867605 0.39103643133811 1.0 0.7724969899895437 10 O95140,P09601 2 +Positive regulation of cell substrate junction organization 0.568308815777393 0.8573243006660984 0.3912656821605376 1.0 0.7724969899895437 6 P60903 1 +Response to axon injury 0.4690102023291321 0.8568084834982328 0.3915507364413275 1.0 0.7724969899895437 11 Q96G23 1 +Viral life cycle 0.3263038369710663 0.8551225601027093 0.3924833014190905 1.0 0.7724969899895437 77 Q14108,P11279,Q9UIV1,Q8WTV0,Q08752,P07237,P62820,Q99816,Q96J02 9 +Regulation of dendrite development 0.4186012170663995 0.8546605379037041 0.3927391029322185 1.0 0.7724969899895437 17 Q8WWV3 1 +Ventricular cardiac muscle cell action potential 0.6114285714285677 0.8524630601340557 0.3939571331212184 1.0 0.7724969899895437 4 Q14126,P15924,P14923 3 +T cell migration 0.4967948727133651 0.8495723602606184 0.395562884223076 1.0 0.7731650551067847 8 P55011,P78536,P05067 3 +Regulation of dna directed dna polymerase activity 0.4966806268238127 0.8490193066709638 0.3958705493192855 1.0 0.7731650551067847 8 P35250 1 +Viral genome replication 0.3613635797567947 0.8478791895488754 0.3965052552838095 1.0 0.7741592306016694 41 Q08752 1 +Reactive nitrogen species metabolic process 0.4305260634543469 0.8473510399423799 0.3967994855096313 1.0 0.7742843184451392 15 P35270,O43169 2 +Negative regulation of erbb signaling pathway 0.5657617653634632 0.8465204481949562 0.3972624715750776 1.0 0.7743412493612651 6 P51149,Q99538,P37198,Q99816 4 +Reactive oxygen species biosynthetic process 0.4668056477339087 0.8450750305914747 0.3980689484891642 1.0 0.7743412493612651 11 Q9BSK2,P00403 2 +Activin receptor signaling pathway 0.6610929853181119 0.8440059741622651 0.3986660672363769 1.0 0.7743412493612651 2 Q9Y2U8 1 +Regulation of activin receptor signaling pathway 0.6610929853181119 0.8440059741622651 0.3986660672363769 1.0 0.7743412493612651 2 Q9Y2U8 1 +Response to estradiol 0.441106016623517 0.8420048918751534 0.3997852152534427 1.0 0.7744958512308678 13 O94788,P04083,O95831 3 +Aspartate transmembrane transport 0.6602773246329525 0.8406934408929277 0.4005196960422406 1.0 0.7754139296236717 2 Q9UJS0 1 +Regulation of mitochondrial membrane permeability involved in apoptotic process 0.4773464011147769 0.839087452876265 0.401420236477914 1.0 0.7763732046166248 10 P45880 1 +Ventricular cardiac muscle tissue morphogenesis 0.6590538336052238 0.83572973968212 0.4033069606325501 1.0 0.7770944252413227 2 Q12948 1 +Muscle organ morphogenesis 0.6590538336052238 0.83572973968212 0.4033069606325501 1.0 0.7770944252413227 2 Q12948 1 +Cardiac muscle tissue morphogenesis 0.6590538336052238 0.83572973968212 0.4033069606325501 1.0 0.7770944252413227 2 Q12948 1 +Hepaticobiliary system development 0.390568235917315 0.8291753204651305 0.4070052079229853 1.0 0.7795870898027332 24 O94788,O75844,P09601 3 +Mrna splice site selection 0.4210306689703229 0.8274300625908712 0.4079933470807626 1.0 0.780024524524363 16 Q13242,Q9UHX1,P09234,Q07955,Q15428 5 +Pteridine containing compound biosynthetic process 0.5607467090977871 0.8252943466229292 0.4092045006626885 1.0 0.780759030111698 6 P00374 1 +Inorganic anion transmembrane transport 0.5601545217829837 0.8227921816338511 0.4106261834988061 1.0 0.780759030111698 6 Q02978,Q9UHG3,Q9UBX3 3 +Small gtpase mediated signal transduction 0.3264327782542943 0.8202548845891509 0.4120708196064153 1.0 0.7815136233914775 68 P41440,Q02818,P80303,Q9Y2I1,Q15555,P11233,P09601,Q15392,P37198,Q13501 10 +Myeloid leukocyte differentiation 0.3969254723485473 0.8189855379322619 0.4127946648254403 1.0 0.781842016094917 22 P04062,Q15904,Q14739 3 +Positive regulation of ubiquitin protein ligase activity 0.7035117855480346 0.8184685084073468 0.4130897168382714 1.0 0.781842016094917 3 Q16763 1 +Body fluid secretion 0.4806422830537297 0.8121952630063495 0.4166795972278603 1.0 0.7839787168367806 9 P00403,Q13505 2 +Cellular defense response 0.7016089125009762 0.811459056748761 0.417102096317314 1.0 0.784042804925348 3 Q08380 1 +Pyrimidine deoxyribonucleoside monophosphate biosynthetic process 0.7015154921194331 0.8111152392733675 0.4172994951372959 1.0 0.784042804925348 3 P04818 1 +Dtmp metabolic process 0.7015154921194331 0.8111152392733675 0.4172994951372959 1.0 0.784042804925348 3 P04818 1 +Pyrimidine deoxyribonucleoside monophosphate metabolic process 0.7015154921194331 0.8111152392733675 0.4172994951372959 1.0 0.784042804925348 3 P04818 1 +Endosome organization 0.4108458578461806 0.8043744577508806 0.4211807479457758 1.0 0.7864794949677438 17 Q14108,P61020,Q8WUX9,Q6IAA8,Q99816,Q13501 6 +Positive regulation of mitotic cell cycle phase transition 0.3770110489271595 0.8034286147521121 0.4217270414507474 1.0 0.7870581554910224 29 Q96DY7,Q9NYL9,P05067 3 +Nuclear transcribed mrna catabolic process 0.3511247205519699 0.8019222148778574 0.4225979548950374 1.0 0.7870581554910224 44 Q15024,P60228,Q9UIV1,Q9Y2L1,Q969T7,Q99729,Q96C86,O60506,Q9Y5S9,Q14103,Q9Y2W1 11 +Endoplasmic reticulum tubular network organization 0.4785454575918926 0.8018141866649738 0.4226604510331659 1.0 0.7870581554910224 9 O95197,Q15041,P57088 3 +Transition metal ion transport 0.4694729837460461 0.7989658293506674 0.424310225992905 1.0 0.7891760241897027 10 Q8N4V1,Q9HD20 2 +Positive regulation of g1 s transition of mitotic cell cycle 0.4280904935453707 0.7975102279912545 0.4251547650971379 1.0 0.7893204892934882 14 Q96DY7 1 +Nik nf kappab signaling 0.4223739247512695 0.797500217032322 0.4251605768472148 1.0 0.7893204892934882 15 O43657,P05067 2 +Generation of precursor metabolites and energy 0.3311455522349126 0.7958225866041811 0.4261351616405071 1.0 0.7903541343988567 154 P14406,P48735,O14949,Q9Y375,O75306,P05067,P31930,Q9BSK2,Q16134,O75874,P13804,O75964,P00403,P20674,O43676,Q15067,Q9UII2,P85037,O15460,Q9UDW1,P04062,P10253 22 +Nervous system process 0.3194504397542672 0.7948069927879743 0.4267257826756336 1.0 0.7910414749569376 81 Q14108,P17900,P18085,P05067,Q9UQB8,O75844,P04062,P50897,Q15555,Q9Y639,Q14168,P10253,Q00169,Q8N0X7,Q99797 15 +Positive regulation of small molecule metabolic process 0.4571716278151834 0.7939358608949664 0.4272327715434043 1.0 0.7912669491002318 11 P04083,P00403,P05067 3 +Cristae formation 0.4837269756691222 0.7865333378571904 0.4315550959820915 1.0 0.7940368943771762 8 Q5XKP0 1 +Negative regulation of transcription by competitive promoter binding 0.6468189233278997 0.7864479370788345 0.4316051088385135 1.0 0.7940368943771762 2 Q9Y2K7 1 +Negative regulation of mrna processing 0.405273662817305 0.7863535049712287 0.4316604145806071 1.0 0.7940368943771762 18 Q13242,P98175,P61978,P38159,P22626,O75494,O00267,Q07021 8 +Erbb signaling pathway 0.4140814170578871 0.7837393224876246 0.4331930841400864 1.0 0.7958453320318915 16 Q9NQC3,Q92600,P49069,P78536,Q99816,P62993,P37198 7 +Release of sequestered calcium ion into cytosol by endoplasmic reticulum 0.5939815569909752 0.7827054160133985 0.4338001210466566 1.0 0.7962481363669264 4 P30626,P78417 2 +Regulation of ryanodine sensitive calcium release channel activity 0.5939815569909752 0.7827054160133985 0.4338001210466566 1.0 0.7962481363669264 4 P30626,P78417 2 +Phosphate ion transmembrane transport 0.6930477257866456 0.7800750717691388 0.435346688466713 1.0 0.7974236101560963 3 Q9UBX3 1 +Phosphate ion transport 0.6930477257866456 0.7800750717691388 0.435346688466713 1.0 0.7974236101560963 3 Q9UBX3 1 +Positive regulation of binding 0.353518109728724 0.7762963611692899 0.4375740211163825 1.0 0.7992317121271855 41 P60903,P41440,Q8IXJ6,P60228,P05067,Q9BUN8,P18074,P15531,O75503 9 +Regulation of viral process 0.3596541172756276 0.7761776846251555 0.4376440801598811 1.0 0.7992317121271855 36 Q08752 1 +Cotranslational protein targeting to membrane 0.4292429189851467 0.7734151193803774 0.4392767448717598 1.0 0.7992317121271855 13 Q15629 1 +Phosphatidylglycerol metabolic process 0.5481412240163914 0.7722467392575472 0.4399683037961259 1.0 0.7992317121271855 6 P40939 1 +Response to nerve growth factor 0.5129972593108438 0.7674449160239987 0.4428170319787265 1.0 0.7992317121271855 7 Q99523,P05067 2 +Protein autoprocessing 0.5653440482684586 0.7672063781792181 0.4429588212993196 1.0 0.7992317121271855 5 Q9UG56 1 +Regulation of response to wounding 0.427891344528962 0.7656261291599843 0.4438987926419084 1.0 0.7992317121271855 13 Q96G23 1 +Cellular response to radiation 0.3589524638881114 0.7627031125886745 0.4456404738716757 1.0 0.7998803782514291 35 Q9NXR7,O75844,Q08752,P31751,Q15555 5 +Blood vessel morphogenesis 0.3254890738334278 0.7626911004915371 0.4456476393115105 1.0 0.7998803782514291 53 Q9NZ08,P04792,P42785,Q9H2J4,P04083,P09601 6 +Ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway 0.56402417971138 0.7618177373753474 0.4461687925615556 1.0 0.8003493774546251 5 Q9Y263,Q8WUX9,Q99816 3 +L alpha amino acid transmembrane transport 0.4703525045130509 0.7613802184074159 0.4464299993019531 1.0 0.8005848022416395 9 Q9Y619,Q15041 2 +Process utilizing autophagic mechanism 0.309395495083067 0.7597661624313143 0.4473943724882712 1.0 0.8010531781137195 117 P04792,O95721,Q9Y4P1,O00267,P21796,P09601,Q13501,P61421,Q8IXJ6,Q9Y679,O43464,P62820,Q99816,Q9BWH2,O75844,P10619,Q93050,P12235,Q9UII2,Q969Q5,P85037,O15118,O95140,Q9UNZ2,P04062,P51809,Q9Y263,Q9Y487 28 +Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 0.4251298191437083 0.7497307894077262 0.4534168598943648 1.0 0.8081735697191226 13 O95881,P46379,O95831,Q8IXB1,P30040 5 +Cellular response to vascular endothelial growth factor stimulus 0.5608009505304059 0.7486849483804084 0.4540471177709198 1.0 0.8089045221856356 5 P04792 1 +Inflammasome complex assembly 0.6833830224405874 0.7449666904316693 0.4562918567697844 1.0 0.8102501694153567 3 Q8IXJ6 1 +Atp synthesis coupled proton transport 0.4472957835360776 0.7417959435381242 0.4582109786780186 1.0 0.8118331358441279 11 O75947,O75964,P56134,P24539,Q9UJZ1 5 +Developmental maturation 0.3564961301447232 0.741751959767138 0.4582376320340962 1.0 0.8118331358441279 35 P07737,P05067,O94788,P04062,P18074,O75503 6 +Myelin assembly 0.6824189871492449 0.7414846107411005 0.4583996593315547 1.0 0.8118866881777967 3 Q9NR77 1 +Cardiac conduction system development 0.6349918433931531 0.7394822939397426 0.4596141874374204 1.0 0.8138037926457343 2 P60953 1 +Nucleobase containing compound transport 0.3066885683215584 0.735881507782652 0.4618028120292408 1.0 0.8172092278368639 94 Q8TB61,Q16630,Q6NUK1,P09651,O43808,O15439,P37198,Q9BSK2,L0R6Q1,Q8NFH4,Q86V81,O00148,Q9H2D1,Q7KZ85,P51991,P41440,P84103,Q9HC21,Q15388,Q07955,P12235,Q9ULX6,P22626,P82979,Q8NFH5,Q06787,Q9H814,Q9BTX1 28 +Pyrimidine containing compound metabolic process 0.394416421231799 0.7336801099416757 0.4631437236233398 1.0 0.8188763884959164 19 Q9H773,P23919,Q9HC21,P15531,P04818,P17812 6 +Dsrna processing 0.4220139926749325 0.7318290089918742 0.4642729406876211 1.0 0.8204019835443908 13 O75844,Q8WYQ5,P22626 3 +Substrate dependent cell migration cell extension 0.6329526916802661 0.7314580307084153 0.4644994307457217 1.0 0.8205080413419997 2 Q14247 1 +Tripartite regional subdivision 0.6789278317759713 0.7289062750270262 0.4660589960904775 1.0 0.8218095050316024 3 P80723 1 +Blastoderm segmentation 0.6789278317759713 0.7289062750270262 0.4660589960904775 1.0 0.8218095050316024 3 P80723 1 +Regulation of t cell differentiation 0.4635110998142496 0.7277934167116483 0.4667400550754028 1.0 0.821932172459829 9 O96005,P04083 2 +Negative regulation of nervous system development 0.4211134865304435 0.7266621249417003 0.4674329607823659 1.0 0.8219774588693618 13 Q9NQC3,Q96G23,Q8IXJ6,Q8N0X7 4 +Regulation of phosphatidylinositol 3 kinase activity 0.6313213703099556 0.7250549639943513 0.4684183116591134 1.0 0.8227893127653765 2 P60953 1 +Regulation of translational initiation by eif2 alpha phosphorylation 0.6764769254232434 0.7201061834020769 0.4714596206693384 1.0 0.8248200123042104 3 Q13217 1 +Myeloid cell apoptotic process 0.5771645051671326 0.7164932704435797 0.4736868213481036 1.0 0.8250894201013547 4 P04083,P78536 2 +Regulation of myeloid cell apoptotic process 0.5771645051671326 0.7164932704435797 0.4736868213481036 1.0 0.8250894201013547 4 P04083,P78536 2 +Trophoblast cell migration 0.6752345981232213 0.7156553233280261 0.4742042038367784 1.0 0.8250894201013547 3 Q7Z739,Q07021 2 +Positive regulation of chemokine c x c motif ligand 2 production 0.628874388254489 0.7154781626313498 0.4743136297771073 1.0 0.8250894201013547 2 P14174 1 +Chemokine c x c motif ligand 2 production 0.628874388254489 0.7154781626313498 0.4743136297771073 1.0 0.8250894201013547 2 P14174 1 +Positive regulation of monocyte chemotaxis 0.628874388254488 0.7154781626313454 0.47431362977711 1.0 0.8250894201013547 2 Q99538 1 +Positive regulation of dna ligation 0.6288743882544819 0.7154781626313217 0.4743136297771246 1.0 0.8250894201013547 2 P18887 1 +Regulation of dna ligation 0.6288743882544819 0.7154781626313217 0.4743136297771246 1.0 0.8250894201013547 2 P18887 1 +Positive regulation of toll like receptor 9 signaling pathway 0.6288743882544778 0.7154781626313066 0.474313629777134 1.0 0.8250894201013547 2 Q9NQC3 1 +Regulation of toll like receptor 9 signaling pathway 0.6288743882544778 0.7154781626313066 0.474313629777134 1.0 0.8250894201013547 2 Q9NQC3 1 +Toll like receptor 9 signaling pathway 0.6288743882544778 0.7154781626313066 0.474313629777134 1.0 0.8250894201013547 2 Q9NQC3 1 +Visual behavior 0.5525034555816003 0.715062299182368 0.4745705485178355 1.0 0.8250894201013547 5 P05067 1 +Endoplasmic reticulum calcium ion homeostasis 0.5011875445554516 0.7148620276176847 0.4746943027336365 1.0 0.8250894201013547 7 Q9UM00,P05067 2 +Insulin receptor signaling pathway 0.3884359900959245 0.7135865749547975 0.4754828614441988 1.0 0.8261701403079582 20 P43490,P31751,P62993,Q9UQB8 4 +Cellular response to light stimulus 0.3913098396941872 0.7129890357011412 0.4758525418527006 1.0 0.8261701403079582 19 Q15555,Q08752 2 +Regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay 0.4414504118506765 0.7111012564645104 0.4770214914438981 1.0 0.8268014595651132 11 O60506,Q9UIV1 2 +Cardiac muscle tissue development 0.377715351350941 0.7082549291863841 0.4787869606089714 1.0 0.8279976634899674 23 O75844 1 +Positive regulation of wound healing 0.5311236628687491 0.7014643949331008 0.483013247186522 1.0 0.8322689797675457 6 P04083,Q16625 2 +Regulation of mitotic centrosome separation 0.6703386372909044 0.6981804471269385 0.4850643528702791 1.0 0.8339370398216354 3 Q9UNZ2,P43487 2 +Localization within membrane 0.3124632582095747 0.6928659104250124 0.4883937046811986 1.0 0.8368581977291192 131 Q86YV9,Q9HD20,P46379,P31751,Q9HD45,Q15904,Q9NS69,Q13501,P60903,Q5W0Z9,O14737,P11233,O60725,P41440,Q15041,Q8N4V1,Q15629,P43307,O15118,P49069,Q14168,O43681,Q9BTX1 23 +Regulation of superoxide metabolic process 0.5709724765832758 0.6924133960742208 0.4886777555323216 1.0 0.8370878542025874 4 P04899,P00374 2 +Regulation of potassium ion transmembrane transporter activity 0.4632052330335353 0.6886879105824031 0.4910196856339244 1.0 0.8387912544384288 8 P05026,P62258,P50570,P54709,Q12955,Q13642,Q96PU5 7 +Mesoderm morphogenesis 0.5278295148797771 0.6878924347271637 0.4915205210058992 1.0 0.839181377327145 6 P17612,P10644 2 +Endosome to lysosome transport 0.4135283404583009 0.6832766804947948 0.494432026703741 1.0 0.8414807017417351 13 Q9UNK0,Q96AX1,Q99523,P51809,Q9H267,Q99816,Q9Y3E7,Q9P253 8 +Mitochondrial adp transmembrane transport 0.6658714110377577 0.6823304677398914 0.4950300117278075 1.0 0.8414807017417351 3 P12235 1 +Regulation of exocytosis 0.359838865082106 0.6818028538795264 0.4953636194663713 1.0 0.8414807017417351 30 P11279,P35080,P51809,P04083,P11233,Q99816,P09601,P04899 8 +Prostanoid metabolic process 0.4353203766486793 0.6790679120967834 0.4970948327356184 1.0 0.841745518840969 11 Q8N4Q0,Q9H7Z7,P04083,Q14914,Q15067,Q15185 6 +Self proteolysis 0.6190864600326218 0.6775200537152719 0.498076050870915 1.0 0.8419726875315139 2 Q99538 1 +Regulation of protein acetylation 0.4022855895592501 0.6755178766593884 0.4993467976187931 1.0 0.8434264527918194 15 Q03164,O75844 2 +Positive regulation of mrna splicing via spliceosome 0.4020204780454102 0.6739190456148678 0.5003627828913011 1.0 0.8442196271145734 15 P62995,Q14011,Q13573,P38159,Q96EP5,Q15427,Q9Y2W1 7 +Protein processing involved in protein targeting to mitochondrion 0.6629987476325971 0.6721876212258142 0.5014642605453701 1.0 0.8450932089302844 3 Q99797 1 +Adp biosynthetic process 0.6170473083197326 0.6696856974244738 0.5030581710920363 1.0 0.8454746248627997 2 P54819 1 +Purine nucleoside diphosphate biosynthetic process 0.6170473083197326 0.6696856974244738 0.5030581710920363 1.0 0.8454746248627997 2 P54819 1 +Histone h2a acetylation 0.5233498082651507 0.6695114430231054 0.5031692836621169 1.0 0.8454746248627997 6 Q86UY6 1 +Cognition 0.3599045050035758 0.6694761709652722 0.503191776315874 1.0 0.8454746248627997 29 P17900,P18085,P05067,P50897,Q9Y639 5 +Response to hepatocyte growth factor 0.6621787025703891 0.6692994837333536 0.5033044560668647 1.0 0.8454746248627997 3 Q8IXJ6,Q99538 2 +Monosaccharide catabolic process 0.4109177292159136 0.6684063175635265 0.5038742639014226 1.0 0.84557272980178 13 P16278 1 +Regulation of map kinase activity 0.4108319507046634 0.667918294656651 0.5041857487052819 1.0 0.84557272980178 13 P04062,P37198 2 +Late endosome to lysosome transport 0.661776145640327 0.6678829078694883 0.5042083385746383 1.0 0.84557272980178 3 Q8WUX9 1 +Positive regulation of interleukin 1 beta production 0.564614751956867 0.6678767725641784 0.5042122552248438 1.0 0.84557272980178 4 P04792 1 +Negative regulation of leukocyte chemotaxis 0.6162316476345804 0.6665593449069913 0.5050536449908538 1.0 0.845611419218953 2 P14174 1 +Regulation of long term synaptic potentiation 0.4897821472101616 0.6646191416398685 0.5062941229844737 1.0 0.8458331261354516 7 Q92542,Q9Y639,P05067,Q13501 4 +Negative regulation of response to biotic stimulus 0.3839826082809199 0.6643430984585371 0.5064707426032697 1.0 0.8458331261354516 19 O43657,Q8IXJ6,Q9UIV1,Q96J02 4 +Dna methylation or demethylation 0.3838675810955503 0.6635813955544053 0.5069582679542917 1.0 0.8458331261354516 19 Q03164,O75844 2 +Response to insulin 0.3307474526256959 0.6631374243949404 0.5072425438963826 1.0 0.8458331261354516 47 Q99523,Q9BSK2,Q9UQB8,P43490,P31751,Q16836,P40939 7 +Positive regulation of low density lipoprotein receptor activity 0.6601387188902568 0.6621291038285405 0.507888485189764 1.0 0.8458331261354516 3 Q9Y2B0,P61978 2 +Positive regulation of atp metabolic process 0.539249257444681 0.6619693659930869 0.5079908546056493 1.0 0.8458331261354516 5 P05067 1 +Positive regulation of nucleotide metabolic process 0.539249257444681 0.6619693659930869 0.5079908546056493 1.0 0.8458331261354516 5 P05067 1 +Sulfur amino acid catabolic process 0.6150081566068576 0.6618778341993787 0.5080495184504441 1.0 0.8458331261354516 2 Q13867 1 +Homocysteine metabolic process 0.6150081566068576 0.6618778341993787 0.5080495184504441 1.0 0.8458331261354516 2 Q13867 1 +Regulation of fc receptor mediated stimulatory signaling pathway 0.6141924959217027 0.6587622194579056 0.5100484716271583 1.0 0.8458331261354516 2 Q06481 1 +Fc receptor mediated stimulatory signaling pathway 0.6141924959217027 0.6587622194579056 0.5100484716271583 1.0 0.8458331261354516 2 Q06481 1 +Negative regulation of golgi to plasma membrane protein transport 0.6141924959217027 0.6587622194579056 0.5100484716271583 1.0 0.8458331261354516 2 O75608 1 +Negative regulation of low density lipoprotein particle clearance 0.6141924959216953 0.6587622194578775 0.5100484716271763 1.0 0.8458331261354516 2 Q92945 1 +Posttranslational protein targeting to endoplasmic reticulum membrane 0.4883683038388071 0.6584327488753655 0.5102600975905056 1.0 0.8458331261354516 7 O43681,P46379 2 +Fatty acid derivative metabolic process 0.3988264688579169 0.6546844751745802 0.5126709227924138 1.0 0.8459856450376216 15 P50897 1 +Eye photoreceptor cell differentiation 0.5611653076255169 0.6546485830709683 0.512694036638401 1.0 0.8459856450376216 4 Q15555,Q8NBN7 2 +Heart morphogenesis 0.3765407757776097 0.6534096789862724 0.5134922005854607 1.0 0.8462043754966394 21 O94788,P10253,O75844 3 +Glycerolipid biosynthetic process 0.3658436282493917 0.6486019260348844 0.5165957102720902 1.0 0.8465941288197234 24 Q9UG56,Q8WTV0 2 +Regulation of calcium ion transmembrane transport 0.4027686578246221 0.6483192808687306 0.516778465983259 1.0 0.8465941288197234 14 P30626,P21796,Q06787,P78417 4 +Mammary gland epithelium development 0.5594870691516921 0.6482351218366942 0.5168328888946103 1.0 0.8465941288197234 4 P31751 1 +Intrinsic apoptotic signaling pathway in response to dna damage 0.3787447251033946 0.6481537537796089 0.5168855097962024 1.0 0.8465941288197234 20 P61978,P46379,O43464,P09601,P13693 5 +Arf protein signal transduction 0.6558386022083647 0.6470827467536108 0.517578390992941 1.0 0.8465941288197234 3 Q15555 1 +Negative regulation of protein localization to cell surface 0.6109298531810828 0.6463436028358116 0.5180568556362859 1.0 0.8465941288197234 2 Q13492 1 +Caveolin mediated endocytosis 0.610929853181083 0.6463436028358109 0.5180568556362863 1.0 0.8465941288197234 2 Q9UNF0 1 +Negative regulation of potassium ion transmembrane transport 0.610929853181083 0.6463436028358109 0.5180568556362863 1.0 0.8465941288197234 2 Q12955 1 +Negative regulation of potassium ion transport 0.610929853181083 0.6463436028358109 0.5180568556362863 1.0 0.8465941288197234 2 Q12955 1 +Autophagosome organization 0.3832605710363658 0.6424004681927309 0.5206131957950291 1.0 0.8482640704425289 18 O95140,Q9UNZ2,Q86Y82,P04062,Q9Y4P1,P62820 6 +Midbrain development 0.377846529588991 0.6421125180018625 0.5208001286448816 1.0 0.8482640704425289 20 O14949,Q8IXJ6,P00367,Q04917,Q9UQR1,P80723,P24539,P27348,O15027 9 +Regulation of mrna metabolic process 0.3047626467062109 0.6388891008493749 0.5228950788254316 1.0 0.8492047681425413 124 Q13242,Q14011,Q9UHX1,Q9Y2L1,P08670,Q99729,Q92804,Q7Z739,Q16630,P09651,Q8IY67,O00267,Q9ULM6,Q9BWF3,P31483,Q15024,Q69YN4,Q9UIV1,Q969T7,Q96C86,Q7KZ85,Q9Y2W1,P84103,Q13573,P38159,O60506,Q9Y5S9,Q13151,Q14103,Q9NQT5,P61978,P22626,P35637,O75494,Q96EP5,Q06787,Q07021 37 +Very long chain fatty acid catabolic process 0.6533165847170875 0.6383022402618687 0.5232769539725819 1.0 0.8495891184431746 3 Q15067 1 +Regulation of establishment of protein localization to mitochondrion 0.3907016047723038 0.6379418056345026 0.5235115627588289 1.0 0.8495891184431746 16 O14737,Q9UII2,P55786 3 +Tor signaling 0.3906931715745869 0.6378896705739104 0.5235455022094628 1.0 0.8495891184431746 16 O75340,P04062,Q9Y2Q5,O75844 4 +Synaptic vesicle membrane organization 0.6528482047128774 0.6366752292123726 0.5243364117621394 1.0 0.8499769201196785 3 O95721 1 +Rrna catabolic process 0.4519167598564902 0.6356583490560446 0.5249991294429022 1.0 0.8501673163669834 8 Q15024,Q9Y6V7,Q9NQT5,Q9Y2L1 4 +Negative regulation of signaling receptor activity 0.6523867809057625 0.6350735181710878 0.5253804675584455 1.0 0.8505502444572993 3 Q99816,P30533 2 +3 utr mediated mrna stabilization 0.5147271772300784 0.6343945384212164 0.5258233729996262 1.0 0.8508200624317567 6 Q13151,P07910,P98175,Q92615 4 +L amino acid transport 0.4359894891616202 0.6307934417601629 0.5281755920803055 1.0 0.8528339835425117 10 Q9Y619,Q15041 2 +Positive regulation of cell death 0.2963149753033657 0.6278513754685138 0.5301013069069369 1.0 0.8543757327437811 97 Q9NR28,O94788,Q08752,O14737,P04083,O95831,P09601,Q9NS69,Q13501 9 +Eye morphogenesis 0.4501742412904725 0.6275328223371167 0.530310028075172 1.0 0.8544885621090922 8 Q15555,O95140,Q8NBN7 3 +Tolerance induction 0.5531934078379807 0.6243194626765973 0.5324178046392058 1.0 0.8564237910298879 4 Q96J02 1 +Regulation of muscle organ development 0.5119302239711268 0.6230831361591733 0.533229891031374 1.0 0.8564237910298879 6 P41440 1 +Release of cytochrome c from mitochondria 0.413978928139164 0.6228831750590338 0.5333612951551028 1.0 0.8564237910298879 12 O14737,O75832,O75223 3 +Positive regulation of transport 0.3036007055721885 0.6226289307448434 0.5335283950433136 1.0 0.8564237910298879 124 Q16630,P08183,Q08752,P31751,P50897,Q9Y282,O43464,O14737,Q99816,P41440,P55786,Q15041,P04083,Q9UII2,P11279,P61978,P30626,P51809,Q9Y263,Q03164,P04899,Q13642 22 +Phagocytosis 0.3583284984165187 0.6203409164237808 0.5350333622239272 1.0 0.8564237910298879 25 P04083,Q8WTV0 2 +Erythrocyte development 0.5285746178362639 0.6198367907884158 0.5353652440835832 1.0 0.8564237910298879 5 Q9NYL9 1 +Intrinsic apoptotic signaling pathway 0.309480775206092 0.6185662471153518 0.5362021431907644 1.0 0.8564237910298879 64 P45880,P13693,Q9NR28,P04792,P46379,P07237,O43464,O95831,P09601,Q8IXB1 10 +Regulation of rna splicing 0.3062967936157905 0.6183207864279449 0.5363639024629212 1.0 0.8564237910298879 78 Q13242,Q14011,Q9UHX1,P09651,Q8IY67,Q9BWF3,P31483,P98175,Q9NW64,Q9Y2W1,P62995,P84103,P52597,Q13573,P38159,P31943,P52756,Q9Y5S9,P55795,Q07955,P26368,P61978,P22626,P35637,Q12849,O75494,Q96EP5,Q06787,Q07021,P31942 30 +Interleukin 1 production 0.4409090953652469 0.6183007492792996 0.5363771080833291 1.0 0.8564237910298879 9 P04792,P05067 2 +Superoxide metabolic process 0.5102153441886951 0.6161681896438915 0.5377835208140844 1.0 0.8575327386694225 6 P04899,P00374 2 +Nucleoside triphosphate metabolic process 0.3357669734265612 0.6148524734847264 0.5386521519126208 1.0 0.8575391112523281 41 Q8IWA4,Q9UJS0,P08754,Q9H773,P23919,O75947,O75964,P56134,P15531,P00403,P24539,P17812,Q9UJZ1,P36542 14 +Regulation of blood circulation 0.3677740466431904 0.6143676078087911 0.5389724358113384 1.0 0.8575391112523281 22 P30626,P10253,O75844 3 +Zymogen activation 0.4781039848944215 0.6138296356633138 0.5393279115018734 1.0 0.8575953751385952 7 Q15392 1 +Regulation of small molecule metabolic process 0.3380420036517798 0.613813780122812 0.5393383901439801 1.0 0.8575953751385952 39 P85037,P05067,O75844,P04083,P00403,Q15120,Q9UBM7 7 +Maintenance of location 0.3141695349148585 0.6129008244970897 0.5399419180696006 1.0 0.8581705389456146 52 P17900,P04062,Q8WTV0,Q9H6V9,P24390 5 +Regulation of cellular carbohydrate metabolic process 0.3675547471223414 0.6128429416356449 0.5399801941057678 1.0 0.8581705389456146 22 Q14108,P85037,O75844,Q15120 4 +Calcium ion export across plasma membrane 0.6015497553017956 0.6110469769111979 0.5411684808692425 1.0 0.8581705389456146 2 P62258 1 +Tube morphogenesis 0.307247119412095 0.6107892502781609 0.5413391108976762 1.0 0.8581705389456146 73 Q9NZ08,P07737,P04792,P42785,Q9UNS1,Q9H2J4,P04083,P11233,P09601 9 +Regulation of carbohydrate metabolic process 0.354955770767023 0.610592368177857 0.5414694764034298 1.0 0.8581705389456146 27 Q14108,P85037,P05067,O75844,Q15120 5 +Regulation of release of cytochrome c from mitochondria 0.4465155925663829 0.6105293871448714 0.54151118261065 1.0 0.8581705389456146 8 O14737,O75832 2 +Cardiac muscle cell proliferation 0.64504283965729 0.6097364024848406 0.5420364363366499 1.0 0.8585611848376866 3 Q12948,P10644 2 +Myeloid leukocyte mediated immunity 0.4315993548490986 0.6091435212083188 0.5424293124289266 1.0 0.8589502584872234 10 P09601 1 +Collagen biosynthetic process 0.5482584434985495 0.6057237063909034 0.5446982392301893 1.0 0.8603618289813201 4 Q92791 1 +Response to radiation 0.3081106608337663 0.605270525870659 0.5449992619697634 1.0 0.8603618289813201 66 Q14011,Q70UQ0,P05067,Q9BRK5,Q9NXR7,O75844,Q08752,P18074,P31751,P04083,Q15555,Q9Y639,Q8NBN7 13 +Positive regulation of actin filament bundle assembly 0.4381114078264531 0.6049369393253731 0.5452208978195068 1.0 0.8603618289813201 9 P60903 1 +Regulation of viral entry into host cell 0.5240916160429967 0.6023285881524194 0.5469554347824717 1.0 0.8619200507188605 5 Q12899,P07237 2 +Cardiac ventricle morphogenesis 0.6425948592411254 0.6013575955586796 0.5476018356889139 1.0 0.8622526646717914 3 P15924,Q12948 2 +Neuromuscular process controlling balance 0.4202813891318666 0.6012945684255137 0.5476438066273865 1.0 0.8622526646717914 11 P17900,P10253 2 +Regulation of response to oxidative stress 0.3790979578126351 0.6005505691204086 0.5481393697644776 1.0 0.8622526646717914 17 P00374,P04792,O43464,P07237 4 +Positive regulation of cell population proliferation 0.2984089353660472 0.6005401116938095 0.5481463368270674 1.0 0.8622526646717914 91 O43663,O75340,O95140,Q9UIV1,Q9BSK2,O94788,Q9H2J4,Q01085,P43490,P04083,P31751,P15531,P49366,P09601,P04899,P43307 16 +U4 snrna 3 end processing 0.5467656762964208 0.6001270806455768 0.5484215459338224 1.0 0.8624653364698356 4 Q15024,Q9NQT5 2 +Establishment of protein localization to organelle 0.3139051684719192 0.5986856671748173 0.549382516787549 1.0 0.8637560753984945 147 O60830,Q99523,Q99595,P46379,Q8N4H5,Q5JRX3,P37198,Q9NS69,Q13501,O43464,O14737,P11233,Q9UI26,Q14108,O14925,P55786,Q15629,O95831,Q9UII2,P11279,O43681,Q99797 22 +L glutamate transmembrane transport 0.5055344474116781 0.597375018434537 0.5502570287478732 1.0 0.8641286038839444 6 Q15041 1 +Regulation of mrna splicing via spliceosome 0.3076702638944233 0.5970726060366907 0.5504589064634353 1.0 0.8641286038839444 58 Q13242,Q14011,Q9UHX1,P09651,Q8IY67,Q9BWF3,P31483,P98175,Q9Y2W1,P62995,P84103,Q13573,P38159,P52756,Q9Y5S9,P61978,P22626,O75494,Q96EP5,Q06787,Q07021 21 +Mitochondrial protein processing 0.5046268740216552 0.5937454829889518 0.5526823571789101 1.0 0.8660705469911184 6 Q9UJZ1,Q99797 2 +Regulation of transporter activity 0.338463156649062 0.588646697967177 0.556098300946634 1.0 0.8690582323225419 35 P05067,Q04917,P30626,P08183,Q03164,Q06787,P78417,Q13642 8 +Regulation of mononuclear cell migration 0.4176512830933981 0.587831132561518 0.5566456450839707 1.0 0.8690582323225419 11 P78536,P05067,Q07021 3 +Response to ischemia 0.4333926429247621 0.5825075255185 0.560224873991412 1.0 0.8690582323225419 9 O95831 1 +Regulation of phospholipase c activity 0.5938009787928237 0.5823722571000661 0.5603159643187638 1.0 0.8690582323225419 2 P35232 1 +Activation of phospholipase c activity 0.5938009787928237 0.5823722571000661 0.5603159643187638 1.0 0.8690582323225419 2 P35232 1 +Activation of protein kinase c activity 0.5938009787928237 0.5823722571000661 0.5603159643187638 1.0 0.8690582323225419 2 P35232 1 +Chaperone mediated protein folding 0.3377038209951379 0.5822392816430165 0.5604055175508225 1.0 0.8690582323225419 35 O14737,Q9H2J4,P04792,Q08752 4 +Regulation of adenylate cyclase activity 0.6360939183764318 0.5792763475520438 0.5624027223641028 1.0 0.8690582323225419 3 P04899 1 +Regulation of cyclase activity 0.6360939183764318 0.5792763475520438 0.5624027223641028 1.0 0.8690582323225419 3 P04899 1 +Molting cycle 0.4254920098881576 0.5792233349720091 0.562438487469286 1.0 0.8690582323225419 10 P18074,O75844 2 +Negative regulation of rna splicing 0.3860606065192049 0.5783953012764851 0.5629972655291253 1.0 0.8690582323225419 15 Q13242,P98175,P61978,P38159,P22626,O75494,Q07021 7 +Regulation of ventricular cardiac muscle cell action potential 0.6352509179926586 0.5764315451821792 0.5643235274821701 1.0 0.8690582323225419 3 P15924,P14923 2 +Bundle of his cell to purkinje myocyte communication 0.6352509179926586 0.5764315451821792 0.5643235274821701 1.0 0.8690582323225419 3 P15924,P14923 2 +Desmosome organization 0.6352509179926586 0.5764315451821792 0.5643235274821701 1.0 0.8690582323225419 3 P15924,P14923 2 +Cardiac muscle cell cardiac muscle cell adhesion 0.6352509179926586 0.5764315451821792 0.5643235274821701 1.0 0.8690582323225419 3 P15924,P14923 2 +Negative regulation of rna catabolic process 0.349133883203037 0.5755682422000894 0.5649070519579635 1.0 0.8697394251589742 28 Q14011,Q99729,Q92804,O60506,P35637,Q06787,Q14103,Q9H814,Q13151,Q9Y2W1 10 +Regulation of nucleotide metabolic process 0.3930266855509213 0.5675538635055871 0.5703379423233386 1.0 0.8759116740742372 13 P05067,Q15120 2 +Primary mirna processing 0.5149519415885941 0.5670067736657679 0.5707095795528168 1.0 0.8762639606294496 5 Q8WYQ5 1 +Regulation of neuron projection development 0.3044315496171182 0.564277900023356 0.572565019337397 1.0 0.8778107486324499 55 Q14108,Q9UQB8,Q96G23,Q8WWV3 4 +Regulation of cardiac muscle contraction 0.4294601622643671 0.5639282788904249 0.5728029436447981 1.0 0.8779462883433581 9 P30626,P17612,P78417 3 +Regulation of reactive oxygen species biosynthetic process 0.4289354231852295 0.5614572321882235 0.574485877700535 1.0 0.8782537931817654 9 Q9BSK2 1 +Negative regulation of map kinase activity 0.4954464307970159 0.5573069835474812 0.5773177051038436 1.0 0.8798500508998238 6 P04062 1 +Dendritic cell chemotaxis 0.6291309669522699 0.5559113927865523 0.578271429547232 1.0 0.8798500508998238 3 Q07021,P27797 2 +Uv protection 0.5345242411418634 0.5547607265988974 0.5790583332545682 1.0 0.8798500508998238 4 P18074 1 +T cell chemotaxis 0.6283901379066829 0.5534435017190862 0.5799597579075415 1.0 0.8798500508998238 3 P55011 1 +Lymphocyte chemotaxis 0.6283901379066829 0.5534435017190862 0.5799597579075415 1.0 0.8798500508998238 3 P55011 1 +Receptor localization to synapse 0.4201806926247534 0.553407050497758 0.5799847121499471 1.0 0.8798500508998238 10 Q14168 1 +Cellular response to molecule of bacterial origin 0.3644136161192362 0.552360866498955 0.5807011366125268 1.0 0.8798500508998238 20 P26583,Q8IXJ6,Q9NUQ9,P08670,Q8WTV0,Q9Y263,P14174 7 +Regulation of homotypic cell cell adhesion 0.6270909832721335 0.5491242598651421 0.5829201775747266 1.0 0.8801474248978061 3 Q12955,Q9Y624 2 +Vesicle targeting 0.3687016912617135 0.5485711305058475 0.583299802466825 1.0 0.8801474248978061 18 O75340,O95721,Q14849,Q9BZH6,Q9NR31 5 +Regulation of protein targeting 0.3609810425638336 0.5474702337905716 0.584055714945396 1.0 0.8801474248978061 21 O14737,P31751,Q9UII2,P55786 4 +Regulation of ion transmembrane transport 0.3224345631138322 0.5467772635979444 0.5845317651979856 1.0 0.8801474248978061 45 P05067,Q04917,P30626,Q15041,O75844,P08183,P21796,Q06787,P78417,Q13642 10 +Amyloid precursor protein catabolic process 0.3882964851196852 0.541256838177823 0.5883305658678224 1.0 0.8818399509188181 13 Q9NQC3,O95197,Q92542,P49755,Q15392 5 +Regulation of leukocyte chemotaxis 0.4246173844429523 0.5411989128756065 0.5883704867331725 1.0 0.8818399509188181 9 O00429,Q99538,P09429,P78536,Q07021,P14174,P27797 7 +Regulation of complement activation 0.6240058235457098 0.5389115031154388 0.5899479195834831 1.0 0.8824864460015193 3 Q07021 1 +Regulation of humoral immune response 0.6240058235457098 0.5389115031154388 0.5899479195834831 1.0 0.8824864460015193 3 Q07021 1 +Complement activation 0.6240058235457098 0.5389115031154388 0.5899479195834831 1.0 0.8824864460015193 3 Q07021 1 +Regulation of multicellular organism growth 0.3877811676831703 0.5384027240593537 0.5902990461491844 1.0 0.882797311065544 13 O75844,P05067 2 +Positive regulation of cell cycle g1 s phase transition 0.3645937720471383 0.537078936571939 0.5912130896925627 1.0 0.8835207745041693 19 Q96DY7 1 +Positive regulation of exocytosis 0.4066824617360079 0.5322049557797095 0.5945840509709219 1.0 0.886193504471541 11 P11279,P51809 2 +Mrna 5 splice site recognition 0.5280245471933015 0.5310818278657045 0.595362076325985 1.0 0.8869239153973563 4 P09234 1 +Positive regulation of locomotion 0.3013371685445396 0.5306157854992684 0.5956850545678058 1.0 0.8871000164114087 55 O75340,P07737,P04792,P05067,Q8WTV0,Q9Y263,P31751,P04083,Q15555,P09601 10 +Carbohydrate homeostasis 0.3403273125962597 0.5285180850825861 0.5971397981472149 1.0 0.8871000164114087 30 P85037,P42785,P30626,P49366,Q15120 5 +Protein localization to endoplasmic reticulum 0.3371343371690654 0.5284192149317278 0.5972084039055376 1.0 0.8871000164114087 32 Q15629,P20290,P24390,O43681 4 +Sensory system development 0.3427891496224107 0.5273446046584972 0.5979543044669331 1.0 0.8879938561996884 28 O95140,O94788,O96019,Q15293,P54802,Q15555,Q8NBN7,Q99797 8 +Regulation of neuron differentiation 0.3648047363181831 0.5237208252690483 0.6004727288106015 1.0 0.8900264365005314 18 Q8WUJ1 1 +Leukotriene biosynthetic process 0.6191650135163984 0.5230157606100262 0.6009632855558138 1.0 0.8903159786012056 3 O14880 1 +Transmembrane receptor protein tyrosine kinase signaling pathway 0.300784979124907 0.5211935402664398 0.6022319536941856 1.0 0.8917665468163902 58 Q9NQC3,O75340,Q8IXJ6,Q92600,P04792,Q99523,P49069,Q9UQB8,P61106,P43490,P31751,P78536,Q9Y639,Q99816,P04899,Q92572,P62993,P37198 18 +Regulation of transcription regulatory region dna binding 0.4199761642749704 0.5195819935835735 0.6033549509643357 1.0 0.8927906985805494 9 O75844 1 +Cellular oxidant detoxification 0.3712850566440032 0.5191613106538447 0.6036482564266215 1.0 0.8927906985805494 16 P00374 1 +Iron ion transport 0.4264482604295838 0.5188328675829661 0.603877295628811 1.0 0.892915060267277 8 Q8N4V1,O15173 2 +Negative regulation of cellular response to growth factor stimulus 0.4262787818659663 0.5180710561130071 0.604408693762696 1.0 0.8934863339520537 8 O75340,Q8N0X7 2 +Demethylation 0.3836338914964431 0.5155141354233994 0.6061937944713187 1.0 0.894408089567263 13 Q16850 1 +Negative regulation of amyloid precursor protein catabolic process 0.4846734696690801 0.5152396776620769 0.6063855457945997 1.0 0.8944192913109069 6 Q9NQC3,O95197 2 +Regulation of generation of precursor metabolites and energy 0.3399256688064835 0.514862414974021 0.6066491665619083 1.0 0.8944192913109069 29 Q9BSK2,P14406 2 +Regulation of monocyte chemotaxis 0.6164830681354578 0.5142785533540108 0.6070572539133008 1.0 0.8944193295158542 3 Q99538,P09429 2 +Negative regulation of histone acetylation 0.5009860237790233 0.5140981856455855 0.6071833458627625 1.0 0.8944193295158542 5 Q01105,Q13363 2 +Protein deneddylation 0.4253831262365006 0.5140489065549199 0.607217798057679 1.0 0.8944193295158542 8 Q99627,Q9BT78 2 +Amyloid beta formation 0.4252542131125726 0.5134705281432719 0.6076222215023372 1.0 0.8945872094776285 8 Q9NQC3,O95197,Q92542 3 +Regulation of nucleotide biosynthetic process 0.4838353479839089 0.5120006702616092 0.6086505404719524 1.0 0.8950566219956321 6 Q15120 1 +Glutathione metabolic process 0.3700412964536431 0.5116526581419969 0.6088941246741135 1.0 0.8951760878263816 16 O75874 1 +Dna replication checkpoint signaling 0.6150787485475322 0.5097237748962069 0.6102449942452233 1.0 0.8958214658552258 3 Q9Y619 1 +Regulation of mitochondrial membrane permeability 0.3786447288079313 0.5094881155893319 0.6104101264976989 1.0 0.8958214658552258 14 P45880 1 +Organonitrogen compound catabolic process 0.3409313489095117 0.5088368638837989 0.6108665776208873 1.0 0.8958214658552258 297 P30519,P28070,Q9H773,P49721,Q16740,Q9UIQ6,P06280,O60502,Q8WTV0,P46379,P50897,P16278,P09601,Q99436,P42892,Q13501,Q6ZXV5,O15382,Q8IXJ6,Q9NRN7,Q9Y679,Q9H2J4,O43464,Q16850,Q99816,O75503,Q9UHG3,Q13510,P28074,Q99519,P13804,P28072,P55786,Q13126,O43847,O75844,P63208,P10619,Q9NUJ1,Q96J02,Q8IXB1,Q9UII2,Q9NZ08,P17900,Q68CQ4,O75832,Q9UG56,P20618,Q9BUN8,P60900,P49069,Q9Y4X5,P04062,Q16763,P54802,Q9Y263 56 +Monocyte chemotaxis 0.4995756296618593 0.5088327262308238 0.6108694781145061 1.0 0.8958214658552258 5 P04083 1 +Negative regulation of lipoprotein particle clearance 0.6144430844553248 0.507666674061637 0.6116871235865617 1.0 0.8962875074436776 3 Q92945,P30533 2 +Nucleoside monophosphate phosphorylation 0.4991110569612949 0.5071016089879906 0.6120835261237656 1.0 0.8964533934997161 5 P23919,Q9Y3D8,P54819 3 +Negative regulation of defense response to virus 0.4825235575757199 0.506941360529436 0.6121959637607817 1.0 0.8964533934997161 6 O43657,Q96J02 2 +Mitochondrion localization 0.3738965295267148 0.5067870070407277 0.6123042738543227 1.0 0.8964533934997161 15 Q8IWA4,Q9UH62,O75153 3 +Response to xenobiotic stimulus 0.3038833317923361 0.5049132859765795 0.6136197420974954 1.0 0.8980512262581544 52 O43169,P08183,Q16836,P07099,P09601 5 +Skin epidermis development 0.4096106714690382 0.5026630299990531 0.6152012064344798 1.0 0.8989744899746996 10 P18074,O75844 2 +Positive regulation of i kappab kinase nf kappab signaling 0.3452241684956603 0.5004045702908692 0.6167902359270125 1.0 0.900338353865023 24 O43657,Q8TB61,P09601 3 +Regulation of system process 0.3140420945522331 0.500056431151739 0.6170353431088078 1.0 0.9004827561123564 47 P05067,Q9UQB8,P30626,P04062,O75844,P10253 6 +Embryonic appendage morphogenesis 0.4508273926543878 0.4984567812079607 0.6181621240108974 1.0 0.901326415490734 7 O94788 1 +Negative regulation of alpha beta t cell activation 0.5188420371727122 0.4981555839805754 0.6183743855967041 1.0 0.901326415490734 4 P04083 1 +Positive regulation of regulated secretory pathway 0.518803824416814 0.4980199113142768 0.6184700080886445 1.0 0.901326415490734 4 P11279 1 +Positive regulation of dna damage response signal transduction by p53 class mediator 0.569738988580759 0.496454951879784 0.6195734628409286 1.0 0.9015719032817464 2 P17844 1 +Sensory perception 0.3361496151142618 0.4960784052574588 0.6198390943927949 1.0 0.9015719032817464 30 Q14108,P50897,Q15555,Q99797 4 +Regulation of mrna binding 0.4795698744296928 0.4955961577250533 0.6201793642056508 1.0 0.9015719032817464 6 P60228 1 +Positive regulation of er associated ubiquitin dependent protein catabolic process 0.5693311582381807 0.4950430111365008 0.6205697599436721 1.0 0.90179516896745 2 P51572 1 +Rna stabilization 0.344057547038691 0.4921248183999166 0.6226311083551703 1.0 0.9038955602092296 24 Q14011,Q92804,O60506,P35637,Q9H814,Q13151,Q14103 7 +Neuron development 0.3022503956960644 0.4906900366316302 0.6236456944207815 1.0 0.9043133159448622 139 P50897,Q9NR77,Q9Y639,O14949,P42892,P05067,Q96G23,Q8WWV3,O43464,O60701,O75503,Q8N0X7,Q14108,P41440,P18085,Q9BVA1,Q9UQB8,P00374,Q9BW83,Q15428,P04062,Q9Y263,Q15555,Q8NBN7 24 +Regulation of post translational protein modification 0.6091041398869907 0.4905046323780223 0.6237768526393415 1.0 0.9043133159448622 3 O75718 1 +Regulation of vasculature development 0.3382919774110749 0.4856910736094219 0.627186213470424 1.0 0.906745735095462 27 Q9NZ08,P04792,P09601 3 +Cardiac ventricle development 0.3880501125860649 0.4855395970117777 0.6272936315666604 1.0 0.906745735095462 12 O75844 1 +Negative regulation of translational elongation 0.5660685154975559 0.4838043427963616 0.6285247327214414 1.0 0.9071490987732144 2 P49458 1 +Regulation of heart contraction 0.3537887681391763 0.482364928379159 0.6295467307622502 1.0 0.9080956604820092 20 P10253,O75844 2 +Penetration of zona pellucida 0.5636215334420955 0.475442640284719 0.6344715080646921 1.0 0.910498196971449 2 P07686 1 +Xenobiotic metabolic process 0.4103394190347419 0.4752666573217576 0.6345969213811342 1.0 0.910498196971449 9 P07099 1 +Positive regulation of hormone secretion 0.4164637562056603 0.4743633948061757 0.6352407916066567 1.0 0.910498196971449 8 P30626 1 +Regulation of cation channel activity 0.3723695063267448 0.4741505211617648 0.6353925739564987 1.0 0.910498196971449 14 P30626,P78417,Q06787,P05067 4 +Schwann cell development 0.4900718562562043 0.4737544363577052 0.6356750295949483 1.0 0.910498196971449 5 P31751 1 +Positive regulation of leukocyte migration 0.4034856211163036 0.4736873880892268 0.6357228482425652 1.0 0.910498196971449 10 P78536,P05067,Q07021 3 +Er associated misfolded protein catabolic process 0.4734497228452012 0.4723010271164358 0.6367119373370063 1.0 0.9108559066409564 6 Q9BUN8,P46379 2 +Negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway 0.4733945169243985 0.4720922422636829 0.6368609495284141 1.0 0.910857545645468 6 P04792 1 +Negative regulation of lymphocyte activation 0.394446401356583 0.4712976666193616 0.6374281817338532 1.0 0.9112456717290636 11 P04083,Q96J02 2 +Lysosomal transport 0.3340794186663013 0.4702425685244 0.638181724205308 1.0 0.9118996569484336 29 Q14108,P11279,Q99523,P51809,Q99816 5 +Dna modification 0.3408139947976339 0.4691781428483734 0.6389423072953018 1.0 0.9125216861992458 24 Q03164,O75844 2 +Positive regulation of interleukin 1 production 0.4436466934645554 0.469000975747024 0.6390689385683432 1.0 0.9125216861992458 7 P04792 1 +Regulation of voltage gated calcium channel activity 0.5102259743993662 0.4678623828862397 0.6398830057801859 1.0 0.91305983683251 4 P30626 1 +Response to hormone 0.3010934834150683 0.4672781189468271 0.6403009092608036 1.0 0.9132330634513892 140 Q99523,Q15185,P42785,Q9BSK2,Q9UQB8,O75874,P04062,P43490,P04083,P31751,Q16836,P16278,P09601,O95831,P40939,Q13185,Q15392,Q96PK6 18 +Circadian regulation of gene expression 0.3669219516456995 0.4663212948017829 0.6409855383749543 1.0 0.913437996114879 15 P43490 1 +Natural killer cell activation involved in immune response 0.60046020464143 0.4631717448531647 0.6432412674343508 1.0 0.913437996114879 3 P11279 1 +Natural killer cell degranulation 0.60046020464143 0.4631717448531647 0.6432412674343508 1.0 0.913437996114879 3 P11279 1 +Positive regulation of leukocyte degranulation 0.60046020464143 0.4631717448531647 0.6432412674343508 1.0 0.913437996114879 3 P11279 1 +Dendritic spine maintenance 0.5599510603588999 0.4630106259060928 0.6433567506057773 1.0 0.913437996114879 2 Q14247 1 +Heart process 0.335231526920889 0.4569008217799518 0.6477423333057253 1.0 0.9153688399089857 26 P30626,O75844,P14923,P78417,P04899,P10253,P17612 7 +Receptor recycling 0.4686746102148387 0.4543340676984351 0.6495883993256251 1.0 0.9165058497127464 6 P49069,P42892 2 +Vacuolar transport 0.3274367049835848 0.4512142412082893 0.6518351465577574 1.0 0.9184136557172428 32 P61421,Q14108,P11279,Q99523,P51809,Q99816 6 +Positive regulation of activated t cell proliferation 0.5550570962479702 0.4466461672887962 0.6551305560702076 1.0 0.920252517455832 2 P09429 1 +Regulation of neurotransmitter levels 0.3432423771709868 0.4461620532943934 0.6554801914114925 1.0 0.920252517455832 22 P50897,O95721 2 +Negative regulation of establishment of protein localization to mitochondrion 0.5542414355628134 0.4439427581306673 0.6570839697589483 1.0 0.9203294769414988 2 P49257 1 +Lens development in camera type eye 0.5938795534700935 0.442756519912367 0.6579418560536316 1.0 0.9203294769414988 3 Q99797 1 +Regulation of granulocyte differentiation 0.553833605220238 0.4425936595186462 0.6580596717351863 1.0 0.9203294769414988 2 Q13619 1 +Response to uv 0.3338877497821201 0.4422965562450897 0.6582746226305591 1.0 0.9203294769414988 25 P18074,Q14011,Q08752 3 +Nerve development 0.4639922700406496 0.4369028445516943 0.6621818089162828 1.0 0.924044233007948 6 Q9H061 1 +Anterograde axonal transport 0.3955002925862957 0.4364413293784288 0.6625165583577144 1.0 0.924044233007948 10 Q14168 1 +Schwann cell differentiation 0.4638415548584161 0.4363449330976304 0.6625864857034158 1.0 0.924044233007948 6 P31751 1 +Negative regulation of guanyl nucleotide exchange factor activity 0.5517944535073472 0.4358744097088727 0.6629278528196445 1.0 0.924044233007948 2 P16949 1 +Plasma membrane organization 0.3507794110392242 0.4354699952402892 0.6632213135323008 1.0 0.924044233007948 18 Q9UQB8,P41440 2 +Negative regulation of inclusion body assembly 0.5513866231647705 0.4345358404953982 0.6638993743278412 1.0 0.924044233007948 2 P25685 1 +Negative regulation of neuron projection development 0.3570021325850301 0.4338473148307016 0.6643993203125436 1.0 0.924044233007948 16 Q9NQC3,Q9NR77,Q96G23,Q8N0X7 4 +Positive regulation of deoxyribonuclease activity 0.5509787928221954 0.4331990422216369 0.6648701746391601 1.0 0.9240975351482912 2 P23396 1 +Wound healing spreading of epidermal cells 0.4785626786443437 0.4322794339058362 0.6655383327446063 1.0 0.9248175343349369 5 O75122,Q96AC1,Q7Z460,P78536 4 +Positive regulation of rna splicing 0.3453335691136694 0.4274723448468466 0.6690353239318516 1.0 0.9273756965392004 20 P62995,Q14011,Q13573,P26368,P38159,Q9NW64,Q96EP5,Q9Y2W1 8 +Regulation of cellular ketone metabolic process 0.3762096236744398 0.4247935752071363 0.6709871616577185 1.0 0.9290359442147778 12 P04083,Q15120 2 +Hydrogen peroxide metabolic process 0.3985000187892449 0.4220020467736174 0.6730235234880237 1.0 0.9311810401102298 9 P00403 1 +Amyloid fibril formation 0.4316925771740109 0.4209722760041828 0.6737753265469464 1.0 0.9316399576945432 7 Q99471,P05067 2 +L serine catabolic process 0.5469004893964198 0.4199294669115569 0.6745369806684534 1.0 0.932108920471545 2 P34897 1 +Positive regulation of cell cycle phase transition 0.3165910718512271 0.4195024449670022 0.6748489682248184 1.0 0.932108920471545 38 Q96DY7,Q9NYL9,P05067 3 +Protein targeting to vacuole 0.3914057620515919 0.4175951885780284 0.6762431151849895 1.0 0.932108920471545 10 Q14108 1 +Establishment of protein localization to vacuole 0.3914057620515919 0.4175951885780284 0.6762431151849895 1.0 0.932108920471545 10 Q14108 1 +Estrogen metabolic process 0.4950583223386636 0.4160861790753892 0.6773469429968686 1.0 0.932831744977647 4 Q53GQ0 1 +Negative regulation of cellular amide metabolic process 0.290658560640769 0.415857220495247 0.6775144849074664 1.0 0.932831744977647 73 Q9NQC3,O95197,Q14011,Q92600,Q9Y2L1,Q7Z739,Q10713,Q9ULM6,Q9BWF3,P31483,Q00577,Q9H9A5,Q15024,Q9UIV1,Q969T7,Q96C86,P04818,P60228,O60506,P00374,Q14103,Q9NQT5,Q06787 23 +Retinal metabolic process 0.5849016521318513 0.4154821746398324 0.6777889615848565 1.0 0.9330011180698806 3 O94788 1 +Positive regulation of release of cytochrome c from mitochondria 0.4734815080923312 0.4143468660706756 0.6786200958341964 1.0 0.9335193814959022 5 O14737 1 +Urogenital system development 0.3174972257278188 0.4137101406909811 0.6790863996001784 1.0 0.933952270939294 35 O94788,P04083,Q9BW83,O75844 4 +Regulation of pattern recognition receptor signaling pathway 0.3530225684212968 0.4104738357221106 0.6814583928111775 1.0 0.9350947982653208 16 P41440,O43657,Q9NUD5 3 +Protein mannosylation 0.5829247102985022 0.4095692513191935 0.682121956873253 1.0 0.935321928902938 3 Q6ZXV5 1 +Protein o linked mannosylation 0.5829247102985023 0.4095692513191926 0.6821219568732537 1.0 0.935321928902938 3 Q6ZXV5 1 +Response to extracellular stimulus 0.2907955074895597 0.4085117184971308 0.6828980290268161 1.0 0.9354988548493406 62 Q9H773,O94788,P80303,Q9UMX5,O95831,P09601 6 +Response to salt 0.5825486493103693 0.4084483573250096 0.6829445373794618 1.0 0.9354988548493406 3 Q14103 1 +Lipid modification 0.3158044181613784 0.4074291667097026 0.683692808723328 1.0 0.9358336431467597 37 P13804,Q16134,P04062,P23786,P31751,Q16836,P16219,P40939,Q15067 9 +Homeostatic process 0.3283192115433638 0.40708093021561 0.6839485489361545 1.0 0.9358336431467597 227 P30519,Q86YV9,P04792,Q9HD20,P42785,Q9UIQ6,Q8WTV0,P50897,P40939,P09601,Q15120,Q9Y639,Q5BJF2,Q15904,Q13501,P61421,P05067,P23786,O75503,P61916,O43847,P18074,P04083,Q16836,Q15067,Q93050,Q9UII2,P85037,P30626,P04062,Q9UHB6,Q16763,Q15555,P13693,Q9Y487,P10253,Q9NYL9 37 +Regulation of transmembrane transport 0.2919228484467106 0.4047272247380902 0.6856780280618437 1.0 0.9371864545009324 53 P05067,P30626,Q15041,O75844,P08183,P31751,P21796 7 +Cellular response to biotic stimulus 0.3263738796356558 0.4044392829944552 0.6858897180787942 1.0 0.9371864545009324 28 P26583,Q8IXJ6,Q9NUQ9,P08670,O75844,Q8WTV0,Q9Y263,Q9UM00,Q96A33,P14174 10 +Positive regulation of tumor necrosis factor mediated signaling pathway 0.4703960800326726 0.4035771360532152 0.6865237016406127 1.0 0.9372781598294084 5 Q13546,P61086,P78536,P0DMV9 4 +Regulation of tumor necrosis factor mediated signaling pathway 0.4703960800326726 0.4035771360532152 0.6865237016406127 1.0 0.9372781598294084 5 Q13546,P61086,P78536,P0DMV9 4 +Positive regulation of transporter activity 0.3557285578979571 0.402467826818156 0.6873397616016859 1.0 0.9374145314027752 15 Q03164 1 +Sodium ion homeostasis 0.4523426741011247 0.3943908521149363 0.6932924965901024 1.0 0.9415083287026084 6 P04899 1 +Rrna 3 end processing 0.4883576574041772 0.39389524254376 0.693658382926801 1.0 0.941590048221484 4 Q15024,Q9NQT5 2 +Natural killer cell activation 0.4675032042630747 0.3935639719376521 0.6939029850061333 1.0 0.9417145599554486 5 P11279,P51809 2 +Ncrna export from nucleus 0.4671782393185357 0.3924443577657878 0.6947299165225393 1.0 0.9422599396985368 5 Q9H814 1 +Response to nutrient 0.3266480981913839 0.3907696226990622 0.6959675307480717 1.0 0.942422690982484 25 P09601 1 +Regulation of oxidative stress induced intrinsic apoptotic signaling pathway 0.3842088232789019 0.3849185394517617 0.7002977697378325 1.0 0.9453943154909158 10 P04792,P07237 2 +Retinoic acid receptor signaling pathway 0.422238429441031 0.383973521996186 0.7009980724161664 1.0 0.9457126967384168 7 O94788 1 +Mismatch repair 0.3892930063363016 0.3816012840038938 0.7027571316842967 1.0 0.9458417089309517 9 Q9UQ84 1 +Sulfur compound biosynthetic process 0.3169514222961117 0.3808729759341285 0.7032975058965838 1.0 0.9458417089309517 33 Q8TB61,Q13126,P50897,O60701,Q53GQ0,Q15120 6 +Protein localization to lysosome 0.375457696668018 0.3797296789069522 0.7041460869004721 1.0 0.9458466755987138 11 Q14108 1 +Vesicle fusion with golgi apparatus 0.5334420880913646 0.3774564986386338 0.7058343866375092 1.0 0.9468510064649514 2 O60763 1 +Regulation of membrane permeability 0.3407291716842209 0.3736173966332929 0.7086889891455401 1.0 0.948450613567412 18 P45880 1 +Antigen processing and presentation of endogenous peptide antigen 0.3929837568873343 0.3735750721571449 0.7087204828329217 1.0 0.948450613567412 8 Q9NZ08,P10321 2 +Antigen processing and presentation of endogenous antigen 0.3929837568873343 0.3735750721571449 0.7087204828329217 1.0 0.948450613567412 8 Q9NZ08,P10321 2 +Leukocyte differentiation 0.3023883808697841 0.3727837881577633 0.7093093697201143 1.0 0.948620433668238 46 P05067,P04062,P04083,P24390,Q15904,Q14739 6 +Photoreceptor cell differentiation 0.4604539616596634 0.3695185352301157 0.7117412601217603 1.0 0.9503037108823368 5 Q15555,Q8NBN7 2 +Response to nitric oxide 0.4453029333335832 0.3693363563999676 0.7118770296923989 1.0 0.9503037108823368 6 O95831 1 +Cellular response to reactive nitrogen species 0.4453029333335832 0.3693363563999676 0.7118770296923989 1.0 0.9503037108823368 6 O95831 1 +Execution phase of apoptosis 0.37304665671372 0.3684019910229225 0.7125735130788171 1.0 0.9503037108823368 11 Q8IXJ6,O95831 2 +Nucleobase containing small molecule interconversion 0.4799999999999946 0.3668477647902742 0.7137325765853264 1.0 0.951336069008967 4 P00568,P54819,Q9Y3D8 3 +Apoptotic mitochondrial changes 0.3219288989672342 0.3658924818949727 0.7144453065395608 1.0 0.9513582119074137 27 P45880,O75832,O14737,O75223,P12235,Q9UII2 6 +Organ growth 0.3452557598515745 0.3654380325547791 0.7147844555414515 1.0 0.9515708509689168 16 P06493,P16435,O75844,P80723,Q96HC4,Q9UGN5,Q99956,P10644,Q12948 9 +Retina homeostasis 0.5677170667584337 0.3652645411676486 0.7149139445266472 1.0 0.9515708509689168 3 P04792 1 +Amine catabolic process 0.4792367698017795 0.36441396709487 0.71554890724239 1.0 0.9516192753643588 4 P49366 1 +Peptidyl tyrosine modification 0.3216686736992298 0.3640172702146769 0.7158451130759551 1.0 0.9516192753643588 27 Q9UIV1,P05067 2 +Regulation of actomyosin structure organization 0.3407240264655523 0.3637861572572433 0.7160177003424055 1.0 0.9516192753643588 17 P60903 1 +Amino sugar catabolic process 0.5289559543230106 0.3637673959912614 0.7160317112522407 1.0 0.9516192753643588 2 Q9UJ70 1 +N acetylneuraminate catabolic process 0.5289559543230106 0.3637673959912614 0.7160317112522407 1.0 0.9516192753643588 2 Q9UJ70 1 +Regulation of heart rate 0.3901575854694155 0.3618552247282096 0.717460221154997 1.0 0.9524196121107708 8 P15924,P30626,P62258,P14923,P17612 5 +Positive regulation of organic acid transport 0.4431171332857161 0.361660354047715 0.7176058571696413 1.0 0.9524196121107708 6 P55011,Q15041,P14174 3 +Regulation of wound healing spreading of epidermal cells 0.4783673469387716 0.3616490913504004 0.7176142746262784 1.0 0.9524196121107708 4 O75122,Q96AC1,Q7Z460 3 +Positive regulation of extrinsic apoptotic signaling pathway 0.3900245298446552 0.3613058496595069 0.717870821271154 1.0 0.9524196121107708 8 Q13546,P30101,P30153,P62136,O43464,Q9UNN5,Q13177 7 +Response to dexamethasone 0.3886213081816934 0.3555253703869539 0.7221960419261482 1.0 0.9558933429877682 8 P04062 1 +Actin filament bundle organization 0.31026753409338 0.3546660947150528 0.7228397542493621 1.0 0.9560576268471436 35 Q9UQB8,P60903,Q9UHB6 3 +Rna destabilization 0.3134027176665129 0.3529216154863137 0.7241472054130269 1.0 0.9567838401491894 33 Q15024,Q9UIV1,Q9Y2L1,Q969T7,Q7Z739,O60506,Q14103 7 +Intracellular receptor signaling pathway 0.2985087759891328 0.3510780660743116 0.725529782650784 1.0 0.9575830411736712 47 P42785,O43657,O94788,Q9NUD5 4 +Cellular response to carbohydrate stimulus 0.3526919391653033 0.350370834543131 0.7260604115499716 1.0 0.9575830411736712 13 P62995,P30626,Q15120,P17612,Q8N183 5 +Glycosylation 0.3169881209946286 0.3499342444566856 0.726388046482362 1.0 0.957737664026402 30 O43505,Q6ZXV5,O75340,P04062,O60502,Q10472,O75503 7 +Exocytosis 0.2888144839859384 0.3489264532900029 0.7271445249556105 1.0 0.9583248339166798 52 P11279,P04899,Q9BRK5,O95721,P35080,P51809,P04083,O60645,P11233,P09601,Q99816,O15439,Q06787,O43760 14 +Sulfur compound metabolic process 0.2841351219473549 0.3464023758406853 0.7290403398523493 1.0 0.9591650840847772 76 Q9H7Z7,Q13126,O75874,P50897,P16278,O60725 6 +Detection of abiotic stimulus 0.4534587315420304 0.3461758199059339 0.7292105855106501 1.0 0.9591650840847772 5 Q9UNS1 1 +Regulation of protein tyrosine kinase activity 0.3807892847870506 0.3451760816690995 0.7299619990567265 1.0 0.9591650840847772 9 P05067 1 +Positive regulation of filopodium assembly 0.4719221932129985 0.3414079261211277 0.7327965089998092 1.0 0.9618637322477784 4 P11233 1 +Retinal ganglion cell axon guidance 0.558955528355775 0.3407346826168752 0.7333033264584521 1.0 0.9621791376637328 3 Q15375,O94813 2 +Protein folding in endoplasmic reticulum 0.3796077961114996 0.3401876485480355 0.7337152191332086 1.0 0.9623002460667488 9 Q8IXB1,Q13217,P07237 3 +Golgi to lysosome transport 0.4706273848389135 0.3373968202894919 0.7358177813193443 1.0 0.9635709041086652 4 P11279 1 +Monocarboxylic acid metabolic process 0.2858939212303268 0.3365564450228219 0.7364512943278574 1.0 0.9637858451369452 129 Q9HB40,Q9H7Z7,P21796,P40939,Q15120,P48735,Q8N4Q0,P05067,Q16134,O75874,P23786,P07099,Q13510,P13804,P04083,Q16836,P16219,Q15067,Q9NUJ1,O94788,Q14914 21 +Positive regulation of mrna metabolic process 0.2875537277134194 0.3360467566901637 0.7368356078490348 1.0 0.9640839728865876 52 Q15024,Q14011,Q9UIV1,Q9Y2L1,Q969T7,Q13573,P38159,Q7Z739,Q96C86,O60506,Q96EP5,Q14103,Q9Y2W1 13 +Protein maturation by protein folding 0.4499795835034624 0.3347668281246576 0.7378009854061691 1.0 0.9643168708755022 5 Q96HE7,O76024,O00170,P27797 4 +Negative regulation of leukocyte cell cell adhesion 0.3728701480254092 0.334709398410501 0.7378443110927462 1.0 0.9643168708755022 10 P04083,Q96J02 2 +Organelle disassembly 0.3048201765679764 0.3318131564909705 0.7400303491604521 1.0 0.9660672854552154 40 Q9BWH2,O95140,P04062,O43464,Q9Y4P1,P21796,P12235,Q9UII2,Q13501 9 +Regulation of endodeoxyribonuclease activity 0.5552835577315408 0.3306811721673276 0.7408853253911352 1.0 0.9660994082153668 3 P06748,P09429 2 +Bone mineralization 0.4335833883074859 0.3287823178567826 0.7423202290517068 1.0 0.9667426238812924 6 O75844 1 +Regulation of ion transport 0.2831585825882702 0.32794421563662 0.7429538414940939 1.0 0.9669731462432252 59 P04899,P05067,P30626,Q15041,O75844,P08183,P51809,P21796,P78417,P55011,Q13642 11 +Lung epithelium development 0.4660922122424916 0.32349719597546 0.746318730758218 1.0 0.9676735944623784 4 Q13155 1 +Production of molecular mediator involved in inflammatory response 0.3754770526883854 0.3228927444853876 0.7467764713170348 1.0 0.9676735944623784 9 Q8IV08 1 +Regulation of guanyl nucleotide exchange factor activity 0.5520195838433347 0.3218601759005745 0.7475586240757566 1.0 0.9676735944623784 3 Q9Y2S7,P16949 2 +Vasculature development 0.2829795066684294 0.3210697872406691 0.7481575054601988 1.0 0.9680004691524522 65 Q9NZ08,P04792,P42785,O94788,Q9H2J4,P04083,P09601 7 +Appendage morphogenesis 0.3799395116077647 0.3203204952468823 0.7487253880515283 1.0 0.9683284464407756 8 O94788 1 +Regulation of biological process involved in symbiotic interaction 0.3798325136061306 0.3198928270717447 0.7490495755691309 1.0 0.9683573449072836 8 Q9BTY2,Q12899,P07237 3 +Peroxisome organization 0.4648979591836686 0.3198762605155968 0.7490621344940269 1.0 0.9683573449072836 4 O00429,P28288,O75381 3 +Positive regulation of protein k63 linked ubiquitination 0.5126427406199141 0.3160867813894545 0.7519366397127274 1.0 0.970446900953136 2 O00571 1 +Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 0.5122349102773354 0.314938391592642 0.7528084314528654 1.0 0.971162290628199 2 P05141 1 +Cellular response to insulin stimulus 0.3028206734690863 0.3147295801933416 0.752966983018438 1.0 0.9711634454341664 40 Q9BSK2,P43490 2 +Osteoblast proliferation 0.5114192495921792 0.3126481663434963 0.7545479798091261 1.0 0.9712909721569072 2 P19525 1 +Regulation of osteoblast proliferation 0.5114192495921792 0.3126481663434963 0.7545479798091261 1.0 0.9712909721569072 2 P19525 1 +Vascular associated smooth muscle contraction 0.5114192495921754 0.3126481663434861 0.7545479798091339 1.0 0.9712909721569072 2 P20020 1 +Regulation of vascular associated smooth muscle contraction 0.5114192495921754 0.3126481663434861 0.7545479798091339 1.0 0.9712909721569072 2 P20020 1 +Roundabout signaling pathway 0.5114192495921754 0.3126481663434861 0.7545479798091339 1.0 0.9712909721569072 2 O94813 1 +Positive regulation of smooth muscle contraction 0.5114192495921754 0.3126481663434861 0.7545479798091339 1.0 0.9712909721569072 2 Q14247 1 +Negative regulation of vascular associated smooth muscle cell migration 0.5114192495921719 0.3126481663434761 0.7545479798091415 1.0 0.9712909721569072 2 Q14344 1 +Intracellular transport 0.2992409725067647 0.312523602249326 0.7546426286920387 1.0 0.9712909721569072 422 Q9UJS0,O60830,Q9Y3B3,Q99595,P49755,Q03001,Q6NUQ1,Q7L5D6,Q10713,Q9Y5M8,Q9BWF3,Q5SRE5,Q00577,P43487,Q9NS69,P36542,P45880,O43772,Q04917,Q9Y282,Q14849,P07437,Q9NW64,Q9Y512,O75503,O60493,O60725,P17612,P30040,P56537,Q14108,Q9Y5J9,Q9Y266,P55786,O75964,O75844,P14923,Q03519,Q15629,O75436,P10619,O95831,P43307,P24390,Q14168,O43681,Q99797,P04792,Q8N4H5,A0AVF1,Q15904,Q13501,P61421,P05067,P61020,Q5W0Z9,P23786,O00148,O14737,Q9UI26,P61916,O14925,Q9BW83,Q96EK5,Q9UII2,P11279,Q9BUN8,P51809,P22626,Q9UBX3,Q99523,Q13409,P46379,Q6NUK1,P31751,P61923,Q4KMP7,Q5JRX3,P37198,Q9Y679,Q86V81,O43464,P62820,Q99816,Q7KZ85,P84103,O75340,P18085,Q9UHY1,Q15041,Q9UH62,O75431,O15118,O95140,Q92973,P82979,P40616,Q9H814,Q16630,P09651,Q9UJZ1,Q9NR31,O75947,Q9BZH6,Q6IAA8,Q15785,P27348,Q9UBV2,P56134,Q15388,P12235,Q92688,Q969Q5,Q9ULX6,P61106,Q8WUX9,Q8NFH5,O75494,P24539,P62841,P61981,Q92572,Q96CS3,Q9H6R4 124 +Response to misfolded protein 0.3777207538366232 0.3114842249443912 0.7554325335089149 1.0 0.972033431220084 8 Q9BUN8,P46379 2 +Atp biosynthetic process 0.3286691843833058 0.3108678074989474 0.7559011186337439 1.0 0.972033431220084 19 Q9UJS0,O75947,O75964,P56134,P00403,P24539,Q9UJZ1 7 +Spinal cord development 0.4027260412038123 0.3107556052363898 0.755986421652757 1.0 0.972033431220084 7 P18074 1 +Negative regulation of actin filament depolymerization 0.3388224367817189 0.3091312488626311 0.7572216893971069 1.0 0.9724705041625632 15 Q9UHB6 1 +Cardiac chamber development 0.3444286308044506 0.3083658710399834 0.7578039484090047 1.0 0.9724705041625632 13 O75844 1 +Macropinocytosis 0.5097879282218627 0.3080940396808321 0.7580107764364683 1.0 0.9724705041625632 2 Q06481 1 +Response to abiotic stimulus 0.3035658046680343 0.307252320740887 0.7586513240045574 1.0 0.9724705041625632 170 P30519,Q14011,Q70UQ0,P08183,Q08752,P07237,P31751,Q9Y639,P09601,Q15120,Q15904,P61421,O75306,Q8IXJ6,P05067,Q9BRK5,Q9NXR7,Q9UNS1,O43464,P62993,P55786,O75844,P18074,P04083,P00403,O95831,P04062,Q15555,Q9Y4P3,Q8NBN7,Q9Y487 31 +Establishment of epithelial cell polarity 0.4017163874131637 0.3070930261092127 0.7587725657729085 1.0 0.9724705041625632 7 O14745,P26038,P61586,P60953,Q13308,Q7Z460 6 +Paraxial mesoderm development 0.509380097879288 0.3069610141577257 0.758873046738374 1.0 0.9724705041625632 2 Q12948 1 +Positive regulation of map kinase activity 0.4268790849673221 0.3062773890741565 0.7593934534305458 1.0 0.9724705041625632 6 P23396,Q12802,P41240,P14174,P30040 5 +Positive regulation of release of sequestered calcium ion into cytosol 0.4591080666227715 0.3025589176327605 0.762226026752582 1.0 0.9745355593183695 4 P30626 1 +Positive regulation of calcium ion transport into cytosol 0.4591080666227715 0.3025589176327605 0.762226026752582 1.0 0.9745355593183695 4 P30626 1 +Calcium ion regulated exocytosis 0.3747877127230287 0.2999082944044058 0.7642471073777757 1.0 0.9754643417766632 8 P51809,Q9BRK5 2 +Response to dsrna 0.3505353503158834 0.2989072252768687 0.7650108340310129 1.0 0.9754643417766632 12 Q9NUD5 1 +Pyrimidine nucleoside triphosphate biosynthetic process 0.3993813223947061 0.2986730757573457 0.7651895022841522 1.0 0.9754643417766632 7 P23919,P15531,P17812 3 +Positive regulation of basement membrane assembly involved in embryonic body morphogenesis 0.5061174551386728 0.2979766783227282 0.765720963533445 1.0 0.9754643417766632 2 O75122 1 +Positive regulation of extracellular matrix assembly 0.5061174551386728 0.2979766783227282 0.765720963533445 1.0 0.9754643417766632 2 O75122 1 +Regulation of extracellular matrix assembly 0.5061174551386728 0.2979766783227282 0.765720963533445 1.0 0.9754643417766632 2 O75122 1 +Enzyme linked receptor protein signaling pathway 0.2758092919801095 0.2973504505632972 0.7661989684277402 1.0 0.9754643417766632 89 O75340,Q8IXJ6,P04792,Q99523,P49069,Q9UQB8,Q9UIQ6,P43490,P31751,Q9Y639,Q99816,P53999,P62993,P37198,Q8N0X7,Q96PK6 16 +Positive regulation of cyclin dependent protein kinase activity 0.5418537150989221 0.2951013754489979 0.767916439034009 1.0 0.97615983605126 3 O75832 1 +Regulation of striated muscle contraction 0.363614660819218 0.2950068267493192 0.7679886646827114 1.0 0.97615983605126 10 P30626,P17612,P78417 3 +Hematopoietic stem cell homeostasis 0.4564723685834139 0.2948084464880449 0.7681402136954638 1.0 0.97615983605126 4 Q14157 1 +Regulation of actin filament length 0.3017155009596567 0.2945480075459449 0.7683391847704684 1.0 0.97615983605126 38 Q9UQB8,Q9NYL9,Q9UHB6 3 +I kappab kinase nf kappab signaling 0.3027401123177869 0.2941530566917213 0.7686409498586579 1.0 0.97615983605126 35 O43657,P04792,Q8TB61,P09601,Q13501 5 +Regulation of body fluid levels 0.3021941710758142 0.2917452361290189 0.7704814195992671 1.0 0.9773052649621168 36 Q86YV9,P04792,P04062,P00403,P15531,Q13505 6 +Detoxification 0.3169091763253255 0.2879575772382616 0.7733792122786767 1.0 0.9796454755576082 23 P00374,O14880 2 +Granulocyte activation 0.434981761377547 0.2872043073094131 0.7739558884387825 1.0 0.9801743981872738 5 P04083 1 +Transcription elongation from rna polymerase i promoter 0.4536988799531032 0.286744378830138 0.7743080543840883 1.0 0.9802470161211124 4 P18074,O15160 2 +Bone development 0.3244689441848488 0.2856216172776078 0.7751679447041948 1.0 0.980902740217305 19 O75844,Q15904 2 +Nucleoside bisphosphate biosynthetic process 0.3160146180121406 0.2821345666700038 0.7778403290218681 1.0 0.982644662349382 23 P50897,Q8TB61,Q9NVE7,Q15120 4 +Icosanoid biosynthetic process 0.3694643007901629 0.2792135993352554 0.7800809077423738 1.0 0.9842338794859624 8 O14880,P04083,Q9H7Z7 3 +Peroxisomal transport 0.4987765089722762 0.2782886371398065 0.7807907979979023 1.0 0.9842338794859624 2 P28288 1 +Activation of innate immune response 0.3296673412002637 0.2777510593783826 0.7812034623435771 1.0 0.9842338794859624 16 Q96PK6,Q8WXF1,Q96ST3,P23246,Q15233,Q9NUD5 6 +Regulation of necrotic cell death 0.3593139836698282 0.2769866531531814 0.7817903545920541 1.0 0.9842338794859624 10 Q13510 1 +Regulation of striated muscle cell differentiation 0.3683565004088391 0.2749596128431049 0.7833472670367954 1.0 0.9845784870325768 8 P42345,Q13547,P49840,O94826,P67809,Q9UGN5,Q9BYT8 7 +Response to endoplasmic reticulum stress 0.2787225190651971 0.2741852503796959 0.78394226243839 1.0 0.9846897900569688 69 Q9Y3C8,P46379,P07237,Q7L5D6,Q6ZXV5,O95881,P57088,Q9Y679,Q9UBU6,Q13217,Q9UBV2,P30040,P41440,Q92905,Q9BS26,Q9UM00,O95831,Q8IXB1,Q96A33,Q9BUN8,Q9H8Y8,Q9Y4P3,O15027,Q96CS3 24 +Type b pancreatic cell apoptotic process 0.4303797468354408 0.273163883809989 0.7847272410779114 1.0 0.9846897900569688 5 P20810,O76024,O00330,P05198 4 +Negative regulation of dna damage response signal transduction by p53 class mediator 0.533107074101332 0.2729723219404565 0.7848744917499539 1.0 0.9846897900569688 3 O75832 1 +Response to iron ii ion 0.4959216965742338 0.2708324532571367 0.7865198982738795 1.0 0.9854490933688598 2 P21399 1 +Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand 0.4477582279047028 0.2697940621930093 0.7873186911773771 1.0 0.9854490933688598 4 P62136,O43464 2 +Nucleoside bisphosphate catabolic process 0.4955138662316531 0.2697765539809296 0.78733216146878 1.0 0.9854490933688598 2 O00154 1 +Fatty acid derivative catabolic process 0.4955138662316531 0.2697765539809296 0.78733216146878 1.0 0.9854490933688598 2 O00154 1 +Ketone body metabolic process 0.4955138662316529 0.2697765539809285 0.7873321614687809 1.0 0.9854490933688598 2 P35914 1 +Negative regulation of release of cytochrome c from mitochondria 0.4473041988956101 0.2685169624901039 0.7883014199541145 1.0 0.9854490933688598 4 O75832 1 +Regulation of cell population proliferation 0.2994818077754312 0.2674188896757313 0.789146657013232 1.0 0.9856332942419928 167 Q13155,P31751,Q9NR77,P09601,P35244,Q15392,Q96DY7,P37198,Q8IXJ6,Q9UIV1,P05067,Q9BSK2,Q96G23,Q9UNS1,Q9H2J4,P43490,O14737,P15531,Q99816,O75340,O75844,Q01085,P04083,Q96J02,P43307,Q9UII2,O43663,O95140,P17096,O94788,P49366,P04899,Q9P032 33 +Tissue regeneration 0.4281231857398854 0.2663786142144245 0.789947633792754 1.0 0.9859844841476658 5 P04083 1 +Regulation of calcium ion transport 0.3177502293146477 0.2662748174532403 0.7900275659671432 1.0 0.9859844841476658 21 P30626,P21796,Q06787,P78417,P04899 5 +Monosaccharide metabolic process 0.2784777638610788 0.2653584135743659 0.790733369249371 1.0 0.9859844841476658 53 P85037,O75844,Q9BTY2,P16278,Q15120,P10253,Q9UBX3 7 +Positive regulation of defense response to virus by host 0.4461224489795861 0.2652053038805921 0.7908513092506524 1.0 0.9859844841476658 4 O60828,O94826,Q96ST3 3 +Positive regulation of establishment of protein localization to mitochondrion 0.3432965436717698 0.2651669516273433 0.7908808526423334 1.0 0.9859844841476658 12 O14737,P55786 2 +Nuclear transcribed mrna catabolic process exonucleolytic 3 5 0.4140276243913809 0.2646633167324975 0.7912688390138065 1.0 0.9859844841476658 6 Q15024,Q9NQT5,Q5RKV6 3 +Regulation of immune response 0.2707910930214198 0.2645974992778468 0.791319546780707 1.0 0.9859844841476658 94 P28070,Q8WXF1,Q7Z739,P46379,P09601,Q9UJZ1,Q9UIV1,Q7KZ85,P41440,P04083,Q96J02,Q9NUD5,Q9NZ08,P11279,O43657,Q9NPR9,O96028,P51809,Q96PK6 19 +Response to bacterium 0.2905777929517423 0.2634364133596303 0.7922142276652209 1.0 0.9859844841476658 46 P26583,Q9NZ08,Q9NUQ9,Q8IXJ6,Q9UQB8,P08670,P61106,Q8WTV0,P81605,Q9Y263,P62820,P78536,Q9BTY2,Q9ULM6,Q13151 15 +N acetylneuraminate metabolic process 0.5291717666258735 0.263293973741545 0.7923240041356348 1.0 0.9859844841476658 3 Q9UJ70,Q8NFW8 2 +Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis 0.4926590538336147 0.2624505877530576 0.7929740756830763 1.0 0.986015402948678 2 P23396 1 +Regulation of innate immune response 0.297613583886136 0.2608408835233389 0.7942152149918309 1.0 0.9869610095520835 38 P26583,Q9NZ08,P11279,Q96PK6,Q9UIV1,Q8WXF1,Q7Z739,Q96ST3,P23246,Q14166,Q15233,Q9NUD5 12 +Positive regulation of leukocyte chemotaxis 0.3881759527979099 0.2592904100981813 0.7954111780933977 1.0 0.987411117142878 7 Q99538,P09429,P78536,Q07021,P27797 5 +Regulation of protein dephosphorylation 0.3165756162635374 0.259038293853464 0.7956056943680627 1.0 0.987411117142878 21 Q86XL3,P04062,Q14738 3 +Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator 0.3639558137720252 0.2582454313886236 0.7962174975217295 1.0 0.9878549415375336 8 P46379,Q13573,P61978 3 +Lung cell differentiation 0.5266957957503572 0.2572947384353654 0.7969512538876948 1.0 0.988367168099094 3 Q13155 1 +Stem cell proliferation 0.3543007822484063 0.2563457129840615 0.7976839022885998 1.0 0.9888776087940784 10 P04062 1 +Proton transmembrane transport 0.2965116043840757 0.2560873951852367 0.7978833547239805 1.0 0.9889258481085956 39 P61421,Q9UDW1,P31930,O75947,O75964,P56134,Q13423,P00403,P20674,P24539,P12235,Q9UJZ1 12 +Myeloid cell homeostasis 0.3020305793341247 0.2552736756861902 0.7985117303161027 1.0 0.9895055841374356 32 P18074,P04083,Q9NYL9,P09601 4 +Purine deoxyribonucleoside metabolic process 0.4889885807504165 0.2532007083633775 0.8001131191518402 1.0 0.9906117543730644 2 P00491 1 +Lymphocyte activation involved in immune response 0.3091980078884304 0.2530773308600438 0.8002084561299299 1.0 0.9906117543730644 24 P11279,O96028,P51809,P04083,Q9UQ84 5 +Protein adp ribosylation 0.3472057561049482 0.2521329803001211 0.8009382786514041 1.0 0.9907224758520792 11 Q8IXJ6,Q9NWY4 2 +Positive regulation of mitotic cell cycle 0.2969491669125838 0.2521291717562757 0.800941222360934 1.0 0.9907224758520792 37 Q96DY7,Q9NYL9,P05067 3 +Protein catabolic process 0.3156764517066264 0.2510924995856461 0.801742594654351 1.0 0.9914402418777742 218 P28070,P49721,Q16740,Q9UIQ6,O60502,P46379,P50897,Q99436,Q13501,Q6ZXV5,Q8IXJ6,Q9Y679,Q9H2J4,O43464,Q16850,Q99816,O75503,Q9UHG3,P28074,P28072,O43847,O75844,P63208,P10619,Q9NUJ1,Q96J02,Q8IXB1,Q9UII2,Q68CQ4,O75832,Q9UG56,P20618,Q9BUN8,P60900,P49069,Q9Y4X5,P04062,Q16763 38 +Regulation of vesicle size 0.5238678090575334 0.2505285930232773 0.8021785955240568 1.0 0.9914566910971488 3 P20339,Q13492 2 +Striated muscle cell differentiation 0.2967904257508723 0.2485403197145938 0.8037163778776297 1.0 0.9925607232811144 36 P41440,Q8IV08,O75844,Q9NYL9 4 +Organic cyclic compound catabolic process 0.283749454231159 0.2472209291724137 0.8047372487881179 1.0 0.9934231367805224 137 P30519,Q14011,P21964,Q9H773,Q9Y2L1,Q99729,Q7Z739,Q92804,Q8WTV0,P09601,Q9Y3B2,Q15024,Q9H9A5,Q9NRN7,Q9UIV1,Q969T7,P62312,P60228,O00584,Q13126,O60506,Q9Y5S9,O95831,Q13151,Q14103,P35637,Q9H814 27 +Vesicle organization 0.276168506537878 0.2461978435722742 0.8055290847755447 1.0 0.9937663365564856 65 Q14108,P60903,Q99523,O95721,P61020,P51809,P31751,P62820,P04083,Q99816,Q13501 11 +Endoplasmic reticulum membrane organization 0.4078535148802954 0.2454267832053588 0.8061259930424305 1.0 0.9941073469670192 6 Q15041 1 +Regulation of response to biotic stimulus 0.2743117167466271 0.2450537436462906 0.8064148182592334 1.0 0.9941073469670192 54 Q9NZ08,P11279,Q8IXJ6,O43657,Q96PK6,Q9UIV1,Q8WXF1,O75844,Q96J02,Q9NUD5 10 +Negative regulation of intracellular steroid hormone receptor signaling pathway 0.3514729950900201 0.2448828713066844 0.806547124684531 1.0 0.9941073469670192 10 P38398,P35232,Q92600,Q99623,Q13547,A5YKK6,P61586,P27797,Q9P253 9 +Import across plasma membrane 0.3291996535673058 0.2443909323023719 0.8069280638778666 1.0 0.9943342415458408 14 P41440,Q15041,P31751 3 +Appendage development 0.3557374204551877 0.2436492611688979 0.807502472857438 1.0 0.9946441177368164 9 O94788 1 +Regulation of endoplasmic reticulum tubular network organization 0.4378911641647595 0.2426427628831521 0.8082821509697247 1.0 0.9954054478155746 4 Q15041,P57088 2 +Positive regulation of protein binding 0.322952360323563 0.2412739028633008 0.8093428359928012 1.0 0.9960360533095842 16 P41440,P05067,Q9BUN8 3 +Tetrahydrofolate metabolic process 0.3503620843189975 0.2404161630123547 0.8100076493284765 1.0 0.9960360533095842 10 P00374 1 +Positive regulation of cell division 0.3497984173816043 0.2381577801534631 0.811758721601296 1.0 0.9960360533095842 10 P37198 1 +T cell differentiation 0.3128740859117631 0.2364172127237532 0.8131089408954071 1.0 0.9960360533095842 21 P04083,P24390,P04062 3 +Mitochondrial cytochrome c oxidase assembly 0.5152712115966734 0.2305323369356335 0.8176781388249805 1.0 0.9970255822871652 3 O75880 1 +Respiratory chain complex iv assembly 0.5152712115966734 0.2305323369356335 0.8176781388249805 1.0 0.9970255822871652 3 O75880 1 +Positive regulation of cellular response to transforming growth factor beta stimulus 0.5152569005288717 0.2304997740603096 0.817703439034247 1.0 0.9970255822871652 3 Q13573 1 +Amyloid precursor protein metabolic process 0.3258912680681908 0.2280232485219684 0.8196281668632701 1.0 0.9985274399841982 14 Q9NQC3,O95197,Q92542,P49755,Q15392 5 +Negative regulation of intrinsic apoptotic signaling pathway 0.301092241342656 0.2276227628229763 0.8199395222673349 1.0 0.9985274399841982 29 P45880,P13693,P04792 3 +Positive regulation of wound healing spreading of epidermal cells 0.4779771615008196 0.2266126762401718 0.8207249344940191 1.0 0.9985274399841982 2 Q96AC1 1 +Positive regulation of striated muscle cell differentiation 0.4779771615008164 0.2266126762401638 0.8207249344940253 1.0 0.9985274399841982 2 Q9UGN5 1 +Behavioral response to pain 0.477977161500816 0.2266126762401633 0.8207249344940257 1.0 0.9985274399841982 2 P17655 1 +Response to pain 0.477977161500816 0.2266126762401633 0.8207249344940257 1.0 0.9985274399841982 2 P17655 1 +Positive regulation of ion transport 0.3015794186133688 0.2264705505572953 0.8208354614959061 1.0 0.9985274399841982 28 P30626,Q15041,P51809,P08183,O00483,P78417,P55011,Q13642,P14174 9 +Establishment of epithelial cell apical basal polarity 0.4015522875817013 0.2263273972866318 0.8209467912191621 1.0 0.9985274399841982 6 O14745,P26038,P61586,P60953,Q13308 5 +Negative regulation of dna binding transcription factor activity 0.3143218768377993 0.2260040350960553 0.8211982819681924 1.0 0.9985274399841982 19 P30626,P09601,Q96J02 3 +Proteoglycan metabolic process 0.5131395734342793 0.2257089334093899 0.8214278095181484 1.0 0.9985274399841982 3 O60701 1 +Proteoglycan biosynthetic process 0.5131395734342793 0.2257089334093899 0.8214278095181484 1.0 0.9985274399841982 3 O60701 1 +Positive regulation of ubiquitin protein transferase activity 0.378093008828318 0.2253874730013764 0.821677856051932 1.0 0.9985274399841982 7 Q16763 1 +Golgi localization 0.4136382196815061 0.224443247438788 0.8224124223346334 1.0 0.9988289671887502 5 O14745,P63104,P48444,P60953 4 +Regulation of organic acid transport 0.3503928622287592 0.2232540460465883 0.823337790564727 1.0 0.9988616877502516 9 P55011,P31751,Q15041,P14174 4 +Negative regulation of type b pancreatic cell apoptotic process 0.4302040816326474 0.2223889675814195 0.8240110994013201 1.0 0.9988616877502516 4 P20810,O76024,O00330 3 +Negative chemotaxis 0.511627906976746 0.2223212491169318 0.8240638115857617 1.0 0.9988616877502516 3 Q15375,O94813 2 +Regulation of smooth muscle contraction 0.5116279069767431 0.2223212491169258 0.8240638115857664 1.0 0.9988616877502516 3 Q14247,P20020 2 +Ribonucleoside triphosphate biosynthetic process 0.3017489096255743 0.2200933618556214 0.8257984445353768 1.0 0.9998488375270692 25 Q9UJS0,O75947,O75964,P56134,P15531,P00403,P24539,P17812,Q9UJZ1 9 +Positive regulation of protein acetylation 0.4115965700285757 0.2187652646678764 0.8268329062382307 1.0 1.0 5 P38398,Q9Y230,Q49A26,O00571 4 +Cellular response to retinoic acid 0.3529412588269646 0.217764762758693 0.8276124009168218 1.0 1.0 8 O94788,O43464 2 +Positive regulation of protein tyrosine kinase activity 0.4265306122448936 0.2129964838529582 0.8313297052384645 1.0 1.0 4 Q15334,P78536,Q13177 3 +Interleukin 6 production 0.3432367698560226 0.2122733689493733 0.8318937704997154 1.0 1.0 10 P04062 1 +Embryonic body morphogenesis 0.5063239494084087 0.2106523235331045 0.8331585800211365 1.0 1.0 3 O75122,Q9Y2X9 2 +Cardiac muscle contraction 0.3196457943744566 0.2090028700612686 0.8344459981118244 1.0 1.0 15 P30626,P10253,P17612,P78417 4 +Positive regulation of vascular associated smooth muscle cell proliferation 0.4248157645971296 0.2086763435597025 0.8347009086789525 1.0 1.0 4 P04899,O95140 2 +Phosphatidylinositol dephosphorylation 0.5045201330855263 0.2067614865810569 0.8361961354211935 1.0 1.0 3 Q9Y217 1 +Phospholipid dephosphorylation 0.5045201330855263 0.2067614865810569 0.8361961354211935 1.0 1.0 3 Q9Y217 1 +Macrophage chemotaxis 0.4690048939641162 0.2062616339930626 0.8365865457675261 1.0 1.0 2 P14174 1 +Macrophage migration 0.4690048939641162 0.2062616339930626 0.8365865457675261 1.0 1.0 2 P14174 1 +Small molecule metabolic process 0.3062270115196527 0.2061293607898009 0.8366898646198746 1.0 1.0 391 Q9Y619,Q9HB40,Q06136,Q9H773,Q9H7Z7,O14880,Q8WTV0,P50897,P21796,P16278,P40939,Q9BQE5,P48735,Q15120,Q15392,Q14739,O15382,Q8N4Q0,P05067,Q969T7,Q16134,O75874,Q14849,P23786,P43490,Q9BTY2,Q16850,P07099,Q9H2D1,Q13510,O60725,Q8IWA4,P41440,P61916,P48449,P13804,P30837,Q13126,O75964,O75844,P00374,P04083,Q16836,P00403,P16219,Q9NUJ1,Q9UBM7,O94788,P04062,P35270,Q9UHB6,Q14914,Q14168,P10253 54 +Regulation of glucose metabolic process 0.3106569625171826 0.204994858993552 0.8375761416643379 1.0 1.0 19 P85037,O75844,Q15120 3 +Glucose import 0.3493382876883903 0.204964406114846 0.8375999344128744 1.0 1.0 8 Q99523 1 +Regulation of receptor internalization 0.3447852760736181 0.2023847743373626 0.8396159304390756 1.0 1.0 9 Q8NBU5,P41440,P07355,P30533,O75955,Q96CW1,Q15334,Q06787 8 +Carbohydrate transmembrane transport 0.3443348429090689 0.2007326861201749 0.8409076000470714 1.0 1.0 9 Q99523 1 +Pigment granule localization 0.4215136658767908 0.2004742683459387 0.8411096803832985 1.0 1.0 4 P62820,Q96AX1 2 +Establishment of protein localization to endoplasmic reticulum 0.3067385832769892 0.1995710773839819 0.8418160496108538 1.0 1.0 21 Q15629,O43681 2 +Multicellular organismal movement 0.3696669644813772 0.198249786126955 0.8428496367188236 1.0 1.0 7 P10253,P78417 2 +Nuclear envelope organization 0.3047011775159801 0.1978596726244376 0.8431548569337486 1.0 1.0 22 Q8IXJ6,Q9UNZ2,Q9ULX6,Q86XL3,O75844 5 +Regulation of intracellular lipid transport 0.4645187601957615 0.1965354504442286 0.8441910882438928 1.0 1.0 2 P07355 1 +Positive regulation of intracellular lipid transport 0.4645187601957615 0.1965354504442286 0.8441910882438928 1.0 1.0 2 P07355 1 +Positive regulation of sterol transport 0.4645187601957615 0.1965354504442286 0.8441910882438928 1.0 1.0 2 P07355 1 +Nuclear ncrna surveillance 0.4989720082611441 0.1950434606665188 0.8453589242316009 1.0 1.0 3 Q15024 1 +Viral budding 0.4027490441833923 0.1948514313261495 0.8455092574922434 1.0 1.0 5 Q8WUX9,Q99816 2 +Cellular response to lipoprotein particle stimulus 0.4189546737578012 0.1942246031082643 0.8460000191755723 1.0 1.0 4 O15118 1 +Protein k29 linked ubiquitination 0.4983200853652366 0.1936913907406663 0.8464175333801904 1.0 1.0 3 Q16763 1 +Positive regulation of potassium ion import across plasma membrane 0.4628874388254634 0.1930734901046376 0.8469014138482109 1.0 1.0 2 P54709 1 +Regulation of potassium ion import 0.4628874388254634 0.1930734901046376 0.8469014138482109 1.0 1.0 2 P54709 1 +Protein insertion into mitochondrial inner membrane 0.4977560179518642 0.1925257633000282 0.8473303891811064 1.0 1.0 3 Q9Y5J9,Q53H12 2 +Multivesicular body organization 0.3897754714840525 0.1921433404562645 0.8476299265763982 1.0 1.0 6 Q8WUX9,Q99816 2 +Negative regulation of fatty acid biosynthetic process 0.4973480212158365 0.1916851007337874 0.8479888774596234 1.0 1.0 3 P38398,P49748 2 +Germ cell migration 0.4620717781402932 0.1913575188368866 0.8482455000607925 1.0 1.0 2 Q12948 1 +Negative regulation of viral life cycle 0.4969246769554816 0.1908149908539866 0.8486705434783266 1.0 1.0 3 Q12899 1 +Negative regulation of viral entry into host cell 0.4969246769554816 0.1908149908539866 0.8486705434783266 1.0 1.0 3 Q12899 1 +Regulation of exit from mitosis 0.3888276992259383 0.1894808372195543 0.8497159727322381 1.0 1.0 6 P50748,Q8IXJ6,Q9UJX2 3 +Taxis 0.2796530381432892 0.1892460434008218 0.8498999821888309 1.0 1.0 48 P26583,Q9NUQ9,P04792,O00264,P05067,Q9BVA1,P04083,Q9Y639,Q9ULM6,P11233,P55011,Q07021,P42892 13 +Regulation of action potential 0.3446595448003201 0.1886824760201054 0.8503416869910021 1.0 1.0 8 P04062,Q06787 2 +Polarized epithelial cell differentiation 0.344644317252669 0.1886301244637613 0.8503827207334143 1.0 1.0 8 O14745,P26038,P61586,P60953,Q13308,P61026,P15311 7 +Bile acid metabolic process 0.3665713118103858 0.1885653859154662 0.8504334641006839 1.0 1.0 7 O15118,Q99714,P22307,Q9BZF3,P28288,Q96SU4 6 +Positive regulation of type i interferon production 0.3153124570750583 0.1873879158536218 0.8513564965418139 1.0 1.0 15 Q9NUD5 1 +Interleukin 8 production 0.3655793766913211 0.1854955160833226 0.8528403968875091 1.0 1.0 7 P04083 1 +Formation of translation preinitiation complex 0.3432422620003333 0.1838279652118622 0.8541484169120213 1.0 1.0 8 P55010 1 +Regulation of leukocyte mediated immunity 0.2960403191009014 0.1837282092407607 0.8542266778317495 1.0 1.0 26 P11279,O96028,P51809,P09601 4 +Convergent extension 0.457585644371954 0.1820989505270499 0.8555050723219613 1.0 1.0 2 Q13263 1 +Axis elongation 0.457585644371954 0.1820989505270499 0.8555050723219613 1.0 1.0 2 Q13263 1 +Amyloid beta metabolic process 0.3353226533561526 0.1820905220469233 0.8555116867006147 1.0 1.0 10 Q9NQC3,O95197,Q92542 3 +Establishment of golgi localization 0.413469387755097 0.1811456332596742 0.8562532668773053 1.0 1.0 4 O14745,P63104,P60953 3 +Endothelin receptor signaling pathway 0.4567699836867901 0.1804482272463529 0.8568006957932921 1.0 1.0 2 P60953 1 +T cell extravasation 0.4567699836867859 0.1804482272463444 0.8568006957932988 1.0 1.0 2 Q9Y624 1 +Glial cell development 0.3081582389202488 0.1792576401516222 0.8577354063091902 1.0 1.0 17 Q8IXJ6,P05067,Q92542,Q96P11,P18074,P31751 6 +Regulation of signaling receptor activity 0.3292861115242326 0.1780346010737336 0.8586958020758788 1.0 1.0 11 P05067 1 +Positive regulation of histone acetylation 0.4114285714285659 0.1763911357896019 0.8599866680988257 1.0 1.0 4 P38398,Q9Y230,Q49A26 3 +Positive regulation of peptidyl lysine acetylation 0.4114285714285659 0.1763911357896019 0.8599866680988257 1.0 1.0 4 P38398,Q9Y230,Q49A26 3 +Skeletal muscle contraction 0.4894303116427002 0.1757801244602636 0.8604666848775671 1.0 1.0 3 P10253 1 +Snrna processing 0.3398040435785067 0.1722044448125854 0.863276803628338 1.0 1.0 8 Q15024,Q96SY0,Q96GM8 3 +Negative regulation of protein containing complex assembly 0.2896137830360683 0.1720692406099436 0.863383094493597 1.0 1.0 33 P45880,P04062,Q9NYL9 3 +Response to organic cyclic compound 0.2802174339449372 0.1699939600239353 0.8650148867192349 1.0 1.0 141 P41440,P05067,P49721,O94788,Q13126,O75874,P04062,P00374,P04083,P16278,P07099,O95831,Q9NUD5 13 +Membrane fusion 0.2926961360492249 0.1693876256021604 0.8654917562031705 1.0 1.0 29 Q8IWA4,P04083,P51809,O95721 4 +Regulation of mitochondrial fission 0.3813842701481841 0.1690442154966052 0.8657618628865731 1.0 1.0 6 P11233 1 +Positive regulation of dna binding 0.3151103014451287 0.1689969949861634 0.8657990050574809 1.0 1.0 13 P18074,Q8IXJ6 2 +Mitotic cytokinetic process 0.3804693932857983 0.1665911223459843 0.8676917794245256 1.0 1.0 6 Q8WUX9,P37198 2 +Negative regulation of receptor internalization 0.4838841289269712 0.1651056173308559 0.8688608517019705 1.0 1.0 3 P07355,P30533 2 +Cardiac conduction 0.3080385756838827 0.1635722551750613 0.8700678876455683 1.0 1.0 16 O75844 1 +Medium chain fatty acyl coa metabolic process 0.4473898858075039 0.1621890678294753 0.8711569684279172 1.0 1.0 2 O00154 1 +Protein destabilization 0.3365423144146104 0.161381533783175 0.8717929099393311 1.0 1.0 8 Q68CQ4 1 +Peptidyl lysine acetylation 0.290101501051991 0.1613315168290938 0.8718323015439438 1.0 1.0 31 Q01105,O75844,P46379,Q03164,Q86UY6 5 +Positive regulation of neuron projection development 0.2962538255997232 0.1578943569715028 0.8745400447709879 1.0 1.0 23 Q14108 1 +Voluntary musculoskeletal movement 0.4781721746226102 0.1545167683736005 0.8772022907432868 1.0 1.0 3 Q96QK1,P18887 2 +Response to topologically incorrect protein 0.2812560327203196 0.1527518307069687 0.8785939853484994 1.0 1.0 43 Q92905,P04792,O95140,Q9BUN8,P57088,P48723,Q9Y679,P46379,Q15629,Q13217,Q9Y4P3,Q96CS3 12 +Regulation of protein polymerization 0.2690937945181965 0.1519778115977074 0.8792044361272802 1.0 1.0 52 P45880,Q9UQB8,Q9NYL9 3 +Nucleolar chromatin organization 0.4001899461275625 0.1513099447633182 0.879731224817206 1.0 1.0 4 Q8IXJ6 1 +Ruffle organization 0.3109917679286012 0.1508331314545933 0.8801073501279948 1.0 1.0 13 Q9UHB6 1 +Macromolecule deacylation 0.2876940898811232 0.1506763631024838 0.8802310198402392 1.0 1.0 32 Q8IXJ6,Q13363,Q9UIF9,P50897,Q5PSV4,Q9NUJ1,Q96PK6 7 +Response to epinephrine 0.474967336917047 0.1487561505404402 0.8817460523657217 1.0 1.0 3 Q8IXJ6 1 +Cellular response to epinephrine stimulus 0.474967336917047 0.1487561505404402 0.8817460523657217 1.0 1.0 3 Q8IXJ6 1 +Regulation of intrinsic apoptotic signaling pathway in response to dna damage 0.3325011035423825 0.1482536843984867 0.8821425658466346 1.0 1.0 8 P13693 1 +Defense response 0.292175017479097 0.1474922411870759 0.882743503392482 1.0 1.0 170 P28070,P10321,P42785,Q8WXF1,P09601,Q9BQE5,Q8IXJ6,Q9UIV1,P05067,Q8IV08,P07437,P62820,Q08380,P68371,O00584,O75844,Q01085,O60506,P04083,Q96J02,Q13151,Q9NUD5,Q9NZ08,P11279,O43657,P49069,P60900,P04062,P51809,P81605,Q9Y263,Q9P032,Q96PK6 33 +Regulation of establishment of protein localization 0.2576446854959703 0.144543418053867 0.8850713737555269 1.0 1.0 105 P55786,Q9Y282,P30626,O96028,Q08752,O14737,P31751,O43464,Q16836,Q16850,P40939,Q9UII2 12 +Regulation of mrna processing 0.2666382741438868 0.1443966644240409 0.8851872506117835 1.0 1.0 76 Q13242,Q14011,Q9UHX1,Q16630,P09651,Q8IY67,O00267,Q9BWF3,P31483,Q69YN4,P98175,Q7KZ85,Q9Y2W1,P62995,P84103,Q13573,P38159,P52756,Q9Y5S9,P61978,P22626,O75494,Q96EP5,Q06787,Q07021 25 +Fatty acid elongation 0.4363784665579132 0.1424555287121952 0.88672020399606 1.0 1.0 2 Q9NZ01 1 +Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 0.4692622782712728 0.1388232734851777 0.8895898024772615 1.0 1.0 3 P78417 1 +Regulation of actin filament bundle assembly 0.299633228762291 0.1385599896715945 0.8897978618634792 1.0 1.0 18 P60903 1 +Extracellular vesicle biogenesis 0.3696069398405759 0.1384745286159409 0.8898653988849838 1.0 1.0 6 Q92905,Q9Y3E7,Q99816 3 +Erythrocyte homeostasis 0.2885245941112503 0.138184208675535 0.8900948350159741 1.0 1.0 28 P18074,Q9NYL9,P09601 3 +Golgi to vacuole transport 0.3691978794003649 0.1374526302974076 0.8906730328184564 1.0 1.0 6 P11279,Q99523 2 +Response to fungus 0.3934693877550969 0.1372149144270161 0.8908609224080934 1.0 1.0 4 Q14019,P04406,P81605 3 +Defense response to fungus 0.3934693877550969 0.1372149144270161 0.8908609224080934 1.0 1.0 4 Q14019,P04406,P81605 3 +Protein polyubiquitination 0.2812616868331768 0.136529344989594 0.8914028277968038 1.0 1.0 40 P55786,Q9Y4X5,P63208,Q9UIQ6,Q16763,Q9Y263,Q96J02 7 +Histone h3 deacetylation 0.3789408600834041 0.1363424696609325 0.8915505513983213 1.0 1.0 5 P23246,Q8IXJ6 2 +Ethanol metabolic process 0.4671607446681854 0.1352683061927316 0.8923997427256196 1.0 1.0 3 P30837 1 +Physiological cardiac muscle hypertrophy 0.3680555555555573 0.1346133151540731 0.892917613464727 1.0 1.0 6 P49840,O94826,Q12802,Q96HC4,Q9UGN5 5 +Regulation of actin filament organization 0.267271723059444 0.1343768904219088 0.8931045546553555 1.0 1.0 52 Q9UQB8,P60903,Q9NYL9,Q9UHB6 4 +Positive regulation of t cell proliferation 0.3280897468145051 0.1342871196518558 0.8931755380183126 1.0 1.0 8 P04083 1 +Positive regulation of mrna processing 0.2978262916550094 0.1339283335411437 0.8934592451898151 1.0 1.0 19 P62995,P08621,Q14011,Q13573,P38159,Q96EP5,Q15427,Q9Y2W1 8 +Tube development 0.2604990108444613 0.1331743905487406 0.89405546380225 1.0 1.0 94 Q9NZ08,P04792,P07737,P42785,O94788,Q9UNS1,Q9H2J4,P46379,P04083,P11233,P09601,Q15185,Q9UII2,P42892 14 +Regulation of wound healing 0.3213251208656976 0.1316967092163782 0.8952241885117784 1.0 1.0 10 P55011,P04083,Q16625 3 +Aminoglycan biosynthetic process 0.3668588263142839 0.1316615705654376 0.8952519830807366 1.0 1.0 6 O43505,Q8NCH0,O60701 3 +Axon development 0.2650607479226544 0.1312399139071293 0.8955855222702485 1.0 1.0 62 P41440,P05067,Q9BVA1,Q9UQB8,Q96G23,P00374,Q9Y639,P42892 8 +Bile acid biosynthetic process 0.3664215686274531 0.1305889057971638 0.896100519457232 1.0 1.0 6 P22307,Q99714,Q9BZF3,P28288,Q96SU4 5 +Response to interferon beta 0.3760612207555702 0.1298655011407003 0.8966728391965741 1.0 1.0 5 O43464 1 +Cellular response to interferon beta 0.3760612207555702 0.1298655011407003 0.8966728391965741 1.0 1.0 5 O43464 1 +Dendritic cell differentiation 0.4286296900489451 0.129665138784374 0.896831364882335 1.0 1.0 2 P09429 1 +Regulation of dendritic cell differentiation 0.4286296900489451 0.129665138784374 0.896831364882335 1.0 1.0 2 P09429 1 +Ventricular cardiac muscle cell development 0.4282218597063648 0.1290168711505112 0.8973442991525162 1.0 1.0 2 P06493 1 +Ventricular cardiac muscle cell differentiation 0.4282218597063648 0.1290168711505112 0.8973442991525162 1.0 1.0 2 P06493 1 +Stress fiber assembly 0.2958142441376044 0.1289855557321459 0.8973690782032218 1.0 1.0 20 P60903 1 +Positive regulation of potassium ion transmembrane transporter activity 0.4630762953896444 0.1285190575049474 0.8977382175773054 1.0 1.0 3 P50570,P54709 2 +Cd40 signaling pathway 0.4622603019175869 0.1271959992500542 0.8987852717992018 1.0 1.0 3 P35232,Q99623 2 +Mitochondrial gene expression 0.2752490764805066 0.1267618445041381 0.8991288957332104 1.0 1.0 46 Q567V2 1 +Insulin metabolic process 0.4265905383360521 0.1264485878838035 0.8993768432085751 1.0 1.0 2 Q96HE7 1 +Tubulin complex assembly 0.3877387149228393 0.1257366907207785 0.8999403573431797 1.0 1.0 4 P61758 1 +Positive regulation of muscle cell differentiation 0.3869387755101977 0.1241742402858545 0.9011773176362547 1.0 1.0 4 P42345,Q9UGN5,Q9BWF3 3 +Peptide antigen assembly with mhc protein complex 0.4249592169657438 0.1239198785770413 0.9013787134335652 1.0 1.0 2 P27797 1 +Endoplasmic reticulum to cytosol transport 0.3149817336368929 0.1234780924108319 0.9017285212465806 1.0 1.0 11 Q9Y679,Q9UBV2,Q9BUN8 3 +Serine family amino acid catabolic process 0.4598123215014352 0.1232773436411435 0.901887481125936 1.0 1.0 3 P34896,P34897 2 +Lipoprotein biosynthetic process 0.3187183011398586 0.1227585679323243 0.902298284034008 1.0 1.0 10 P04062 1 +Muscle cell proliferation 0.2919621697503188 0.122597403083099 0.9024259109707472 1.0 1.0 22 P04899,O95140,P09601 3 +Regulation of oxidative stress induced cell death 0.3009977478121736 0.1190584511417619 0.905229047728268 1.0 1.0 15 P04792,O43464,P07237 3 +Regulation of receptor recycling 0.3710372953340689 0.1188835063913364 0.9053676490761138 1.0 1.0 5 P42892 1 +Positive regulation of catabolic process 0.2594754225371956 0.1188283350491167 0.9054113596019132 1.0 1.0 111 Q15024,Q6ZXV5,Q8IXJ6,O75832,Q9UIV1,Q969T7,P05067,Q9Y2L1,O43847,P04062,P46379,O60506,P31751,P21796,P09601,Q96J02,Q14103,Q9UII2 18 +Cellular extravasation 0.4569563443492446 0.1188012333508774 0.905432831533238 1.0 1.0 3 P05556,Q9Y624 2 +Cell adhesion mediated by integrin 0.4569563443492423 0.1188012333508738 0.905432831533241 1.0 1.0 3 P05556,P78536 2 +Regulation of myelination 0.3424407847481975 0.1186913485146403 0.905519890979886 1.0 1.0 7 Q8IXJ6 1 +Response to retinoic acid 0.3174715283928467 0.1185352154995195 0.9056435938394416 1.0 1.0 10 O94788,O43464 2 +Regulation of cysteine type endopeptidase activity 0.2784373043358261 0.1181623918878554 0.9059389880699502 1.0 1.0 41 O75340,Q9NR28,O43464,O14737,O95831,Q15392 6 +Positive regulation of immune effector process 0.2829210011503934 0.1171313503695666 0.906755966721038 1.0 1.0 32 P04083,P11279,O96028,P09601 4 +Cellular response to ionizing radiation 0.2953000686810726 0.1159734020684987 0.9076736216046531 1.0 1.0 18 Q9NXR7,O75844 2 +Regulation of skeletal muscle cell differentiation 0.4532843737250125 0.1131972414119579 0.9098741826464 1.0 1.0 3 Q9BYT8,P17844 2 +Suppression of viral release by host 0.381167574299555 0.1131915535136068 0.9098786919511452 1.0 1.0 4 Q12899 1 +Negative regulation of striated muscle cell differentiation 0.3679052674561055 0.1122429618179564 0.9106307657676171 1.0 1.0 5 Q13547,O94826,P67809,P49840 4 +Histone h3 k4 trimethylation 0.3383898664998573 0.107984868128417 0.9140076954994364 1.0 1.0 7 Q03164 1 +Exocytic process 0.3061803675095929 0.1078971655279322 0.9140772655778096 1.0 1.0 12 O95721 1 +Regulation of myotube differentiation 0.4492044063647555 0.1071691092858867 0.91465482148025 1.0 1.0 3 P42345,Q9BYT8 2 +Nucleoside triphosphate biosynthetic process 0.2828894376455787 0.1071189679100555 0.9146945995304204 1.0 1.0 30 Q9UJS0,P23919,O75947,O75964,P56134,P15531,P00403,P24539,P17812,Q9UJZ1,P36542 11 +Endosome transport via multivesicular body sorting pathway 0.364100738268503 0.1043904945593156 0.9168594657119804 1.0 1.0 5 Q8WUX9,Q99523 2 +Multivesicular body sorting pathway 0.364100738268503 0.1043904945593156 0.9168594657119804 1.0 1.0 5 Q8WUX9,Q99523 2 +Organism emergence from protective structure 0.4110929853181091 0.1040041803075097 0.9171660311583594 1.0 1.0 2 Q8IWS0 1 +Rna surveillance 0.3538754894490053 0.1011592722797069 0.9194240268276476 1.0 1.0 6 Q15024,Q9NQT5,Q5RKV6 3 +Positive regulation of peptidase activity 0.2774883399779222 0.1010349352105304 0.9195227277717776 1.0 1.0 35 O75340,Q9NR28,P05067,Q92542,Q9UL46,O43464,O14737,O95831,Q92688 9 +Regulation of gene silencing by rna 0.2969133261572934 0.1004992273681752 0.9199479962042728 1.0 1.0 15 O75844 1 +Response to lipid 0.2593068496455364 0.1001879010110765 0.9201951512782824 1.0 1.0 113 O15118,O94788,Q13126,O75874,P04062,Q8WTV0,O43464,O15173,P04083,O95831,P16278,Q15120,Q13185,Q15185,Q13151,Q14103 16 +Mrna catabolic process 0.2610677418751895 0.1000175154688741 0.9203304198381412 1.0 1.0 85 Q14011,Q92945,Q9Y2L1,P08670,Q99729,Q92804,Q7Z739,Q9ULM6,Q5RKV6,Q6PGP7,Q8NC51,Q969Z0,Q15024,Q9H9A5,P98175,Q9UIV1,Q969T7,Q96C86,Q92615,P62312,Q9Y2W1,P51114,P60228,P51116,O60506,Q9Y5S9,Q13151,Q14103,Q9NQT5,Q9UKD2,P35637,Q06787,P07910 33 +Keratinocyte differentiation 0.2980440717519484 0.0996919754567121 0.9205888714626516 1.0 1.0 14 P04083,Q13510 2 +Positive regulation of phosphoprotein phosphatase activity 0.3714285714285683 0.0958137517549423 0.9236684952897464 1.0 1.0 4 Q15257,P42345,Q8IV63 3 +Positive regulation of phosphatase activity 0.3714285714285683 0.0958137517549423 0.9236684952897464 1.0 1.0 4 Q15257,P42345,Q8IV63 3 +Secondary metabolic process 0.3697959183673425 0.0930424966289724 0.9258698002021748 1.0 1.0 4 P15121,P40616,P14550 3 +Muscle tissue development 0.2746709136301642 0.0927604783100535 0.9260938493259584 1.0 1.0 42 O94788,P41440,O75844,P60660 4 +Negative regulation of catabolic process 0.2606799493996155 0.0924669086996096 0.9263270815857956 1.0 1.0 84 P85037,Q14011,Q8IXJ6,O15118,P49069,Q99729,Q92804,Q9H2J4,P46379,P35637,O60506,P10619,Q16850,P09601,Q13151,Q14103 16 +Regulation of mrna export from nucleus 0.3693003939880565 0.0922094458574162 0.926531633311853 1.0 1.0 4 Q7KZ85 1 +Regulation of cation transmembrane transport 0.2762440034466012 0.0920147187150286 0.926686345360238 1.0 1.0 35 P05067,Q04917,P30626,P21796,Q06787,P78417,Q13642 7 +Androgen metabolic process 0.4381884944920391 0.0919277966978184 0.9267554063935036 1.0 1.0 3 O95470,P51659 2 +Lipophagy 0.3687183546550762 0.0912357344253685 0.9273052813817716 1.0 1.0 4 Q9Y679,O15269 2 +Cell communication by electrical coupling involved in cardiac conduction 0.3568018228846258 0.0899858421873101 0.9282984654794864 1.0 1.0 5 P30626 1 +Regulation by virus of viral protein levels in host cell 0.4365565075479396 0.0897969734755803 0.9284485532920695 1.0 1.0 3 Q16531,O95793 2 +Response to cold 0.3054697426846642 0.0897110271231381 0.9285168529015984 1.0 1.0 11 P00403,Q14011,Q13217 3 +Regulation of cell growth involved in cardiac muscle cell development 0.3677551020408127 0.0896356270991678 0.9285767720176672 1.0 1.0 4 O94826,Q9UGN5,P49840 3 +Chaperone mediated protein complex assembly 0.2960759667414601 0.0884595881362923 0.9295114023751958 1.0 1.0 13 Q15185,Q9Y375 2 +Neural nucleus development 0.2888997719656882 0.0870341219445527 0.930644389615793 1.0 1.0 19 Q8IXJ6,P00367,Q04917,Q9UQR1,P80723,P24539,P27348,O15027 8 +Microtubule bundle formation 0.3003762168203807 0.0860765467237009 0.9314055674185108 1.0 1.0 12 O43663,Q15555,A0AVF1 3 +Collagen metabolic process 0.3087120395465604 0.0826516140375245 0.9341285595686746 1.0 1.0 9 P08670,Q92791 2 +Zymogen inhibition 0.430028559771521 0.0815971655145861 0.9349670553716128 1.0 1.0 3 P20810,Q9HB09 2 +Positive regulation of substrate adhesion dependent cell spreading 0.3029532677768124 0.0811329684866661 0.9353362070427962 1.0 1.0 11 P60903 1 +Meiosis i cell cycle process 0.2940619621018045 0.080471784023433 0.9358620365266996 1.0 1.0 13 Q92791,Q9BTX1 2 +Regulation of actin filament based movement 0.3438883878638628 0.0796269245845467 0.936533980482037 1.0 1.0 6 P30626 1 +Regulation of mitochondrial mrna stability 0.3902936378466533 0.0792380730749677 0.936843261846582 1.0 1.0 2 Q969Z0 1 +Positive regulation by host of viral transcription 0.3507554103715825 0.0787125418749785 0.9372612694602538 1.0 1.0 5 Q9H1E3,Q14684,Q12824,Q13573 4 +Negative regulation of mrna 3 end processing 0.360090224498739 0.0774056747292465 0.9383008265483936 1.0 1.0 4 Q5VTR2,O00267 2 +Cell communication by electrical coupling 0.325704944830412 0.076458379668256 0.9390544252202592 1.0 1.0 7 P05023,P05026,P30626,Q12955,Q16643,P17612 6 +Defense response to symbiont 0.2642555297188552 0.0755460090181108 0.9397802921954288 1.0 1.0 50 O75844,Q9UIV1,Q9NUD5 3 +Pyrimidine ribonucleoside triphosphate metabolic process 0.3487679827818767 0.0751376622251921 0.940105182382847 1.0 1.0 5 P15531 1 +Pyrimidine ribonucleoside triphosphate biosynthetic process 0.3487679827818767 0.0751376622251921 0.940105182382847 1.0 1.0 5 P15531 1 +Epithelial cell maturation 0.3858075040783058 0.0746592569456024 0.9404858254052172 1.0 1.0 2 P04818 1 +Amino acid import 0.3248876174908039 0.0745326012022489 0.9405866012905316 1.0 1.0 7 Q9H9B4,O14745,P08195,P05556,Q15041,O75915 6 +Golgi vesicle budding 0.4218686250510007 0.0720644355636027 0.942550628918072 1.0 1.0 3 Q9BVK6,P49755 2 +Copi coated vesicle budding 0.4218686250510007 0.0720644355636027 0.942550628918072 1.0 1.0 3 Q9BVK6,P49755 2 +Positive regulation of cytokine production 0.2664261106291507 0.0706795988644729 0.9436527579705178 1.0 1.0 48 P41440,P04792,P05067,P09601,Q9NUD5 5 +Response to lithium ion 0.3813213703099518 0.0703378564614254 0.9439247520087988 1.0 1.0 2 P27797 1 +Cilium organization 0.2675170332452818 0.0698479054722994 0.9443147172052728 1.0 1.0 47 P61421,P18085,O95721,Q9BW83,P62820,Q15555,Q4KMP7,O15439,A0AVF1,A6NIH7 10 +Calcium ion transport 0.2722592976230801 0.0694343938774077 0.944643852616486 1.0 1.0 41 P04899,P30626,O75844,P21796,Q9UM00,P13693,Q9UJZ1 7 +Regulation of lyase activity 0.3544911417428858 0.0690325693001351 0.9449636947756874 1.0 1.0 4 P04899 1 +Vesicle targeting rough er to cis golgi 0.3052676532617278 0.0684123542627075 0.9454573875925174 1.0 1.0 8 O75340,P49755,Q9NR31 3 +Protein localization to postsynapse 0.3442221314822434 0.0672034491483891 0.9464197393111488 1.0 1.0 5 Q96QK1,Q4V328,P61006,Q15334 4 +Late endosome to golgi transport 0.4173806609547069 0.0671542181707138 0.9464589314114016 1.0 1.0 3 Q8IWJ2,O60493 2 +Golgi disassembly 0.4165646674826654 0.0662864206101712 0.9471497942298156 1.0 1.0 3 P06493,Q92538 2 +Regulation of t cell proliferation 0.2899711802871095 0.0660828752689429 0.9473118446024208 1.0 1.0 14 P04083,P49366,Q96J02 3 +Multicellular organismal signaling 0.2804762556407807 0.0660148723730954 0.9473659848420652 1.0 1.0 23 P04062,O75844 2 +Coenzyme a metabolic process 0.3370232037484653 0.0658148224142164 0.947525255242889 1.0 1.0 6 Q9NVE7 1 +Very long chain fatty acid metabolic process 0.32074767580862 0.0649768974443177 0.9481923945435804 1.0 1.0 7 Q9NZ01,Q15067 2 +Regulation of nad p h oxidase activity 0.4152363355717549 0.0648900509489732 0.9482615420922424 1.0 1.0 3 P04899 1 +Positive regulation of nad p h oxidase activity 0.4152363355717549 0.0648900509489732 0.9482615420922424 1.0 1.0 3 P04899 1 +Platelet derived growth factor receptor signaling pathway 0.3514285714285665 0.0646510219080574 0.9484518600410708 1.0 1.0 4 P18031,O14745,O95470 3 +Dna deamination 0.4147212741938799 0.0643540194370401 0.9486883412653404 1.0 1.0 3 Q9NQT5 1 +Regulation of anaphase promoting complex dependent catabolic process 0.3727569331158216 0.0627780329575539 0.9499432585187024 1.0 1.0 2 P24941 1 +Negative regulation of leukocyte proliferation 0.3408455236929773 0.0615280543277945 0.9509386726033348 1.0 1.0 5 Q96J02 1 +Negative regulation of t cell proliferation 0.3408455236929773 0.0615280543277945 0.9509386726033348 1.0 1.0 5 Q96J02 1 +Gliogenesis 0.2692038693999659 0.0600357069910707 0.9521271959013444 1.0 1.0 44 O75306,Q8IXJ6,P05067,Q96G23,P04062,P18074,P31751,P04083 8 +Regulation of receptor binding 0.366639477977167 0.0579096668066598 0.9538205830479898 1.0 1.0 2 P07355 1 +Calcium ion regulated exocytosis of neurotransmitter 0.3666394779771588 0.0579096668066534 0.9538205830479948 1.0 1.0 2 Q15042 1 +Ribonucleoside triphosphate metabolic process 0.2733871550551058 0.0575487732104283 0.9541080550519973 1.0 1.0 33 Q8IWA4,Q9UJS0,O75947,O75964,P56134,P15531,P00403,P24539,P17812,Q9UJZ1,P36542 11 +Primary alcohol metabolic process 0.286918430752661 0.0570031133115135 0.954542715111884 1.0 1.0 15 O94788,P51648,Q8NBN7,P30837 4 +Regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator 0.345265149782442 0.0562535288029456 0.9551398388181432 1.0 1.0 4 P61978 1 +Kinetochore assembly 0.3625611745513908 0.0548991693614716 0.9562187936362176 1.0 1.0 2 P50748 1 +Neurotransmitter receptor transport endosome to postsynaptic membrane 0.3440816326530553 0.0547047008401794 0.9563737242440766 1.0 1.0 4 Q96QK1,Q4V328,P61006 3 +Neurotransmitter receptor transport to plasma membrane 0.3440816326530553 0.0547047008401794 0.9563737242440766 1.0 1.0 4 Q96QK1,Q4V328,P61006 3 +Proteasome assembly 0.3160618717253687 0.0545638370305417 0.956485949686772 1.0 1.0 7 O75832 1 +Negative regulation of cell projection organization 0.2783492871266791 0.0542194390739184 0.9567603333222684 1.0 1.0 23 Q9NQC3,P08670,Q96G23,P35080,Q9NR77,Q8N0X7 6 +Phosphorylation of rna polymerase ii c terminal domain 0.3613376835236579 0.0540316103094638 0.9569099796328104 1.0 1.0 2 Q9NYV4 1 +Positive regulation of rna binding 0.3360576748491153 0.0537978878662394 0.9570961923230388 1.0 1.0 5 P60228 1 +Regulation of exosomal secretion 0.3356472029399803 0.0531524150195938 0.957610469295844 1.0 1.0 5 P51149,Q8WUM4,Q9Y3E7,Q99816 4 +Necrotic cell death 0.2864324903772234 0.0519198907064627 0.9585925251581108 1.0 1.0 14 Q13510 1 +Negative regulation of axonogenesis 0.3347613666460751 0.0517686783988204 0.9587130130892833 1.0 1.0 5 Q8N0X7 1 +Positive regulation of early endosome to late endosome transport 0.4010607915136749 0.0512165369805654 0.9591529745335116 1.0 1.0 3 P26038,P35241 2 +Positive regulation of cytoplasmic transport 0.4010607915136749 0.0512165369805654 0.9591529745335116 1.0 1.0 3 P26038,P35241 2 +Cellular sodium ion homeostasis 0.3340138832176432 0.0506108847161284 0.9596355891933144 1.0 1.0 5 P55011,Q96PU5,P54709,P05026 4 +Mesenchymal cell development 0.2965769379286182 0.0486238841789897 0.9612190356524948 1.0 1.0 9 O94788 1 +Neural crest cell differentiation 0.2965769379286182 0.0486238841789897 0.9612190356524948 1.0 1.0 9 O94788 1 +Negative regulation of peptidyl lysine acetylation 0.313235322555629 0.0484902196101125 0.9613255588946245 1.0 1.0 7 Q01105,Q13363 2 +Negative regulation of cell cycle checkpoint 0.3977968176254577 0.0483769721774701 0.9614158113528228 1.0 1.0 3 Q96FV9,Q13838 2 +Negative regulation of dna damage checkpoint 0.3977968176254577 0.0483769721774701 0.9614158113528228 1.0 1.0 3 Q96FV9,Q13838 2 +Positive regulation of endothelial cell development 0.3523654159869486 0.0481517649690497 0.9615952915402408 1.0 1.0 2 Q9Y624 1 +Glomerular epithelial cell differentiation 0.3511419249592129 0.0474135448993317 0.9621836338931128 1.0 1.0 2 P80723 1 +Mesoderm development 0.2956110407552349 0.0460601945280021 0.9632622724799732 1.0 1.0 9 P17612,P63173,P10644 3 +B cell activation involved in immune response 0.2842808110658985 0.0460011496444449 0.9633093335974484 1.0 1.0 15 O96028,Q9UQ84 2 +Somatic diversification of immunoglobulins involved in immune response 0.2842808110658985 0.0460011496444449 0.9633093335974484 1.0 1.0 15 O96028,Q9UQ84 2 +Immunoglobulin production involved in immunoglobulin mediated immune response 0.2842808110658985 0.0460011496444449 0.9633093335974484 1.0 1.0 15 O96028,Q9UQ84 2 +Midbody abscission 0.3355102040816274 0.0440897411598496 0.9648328702025644 1.0 1.0 4 Q8WUM4,Q8WUX9,Q9Y3E7 3 +Apoptotic process involved in morphogenesis 0.3438009787928232 0.0432874404049167 0.9654724029437594 1.0 1.0 2 Q12948 1 +Dopamine metabolic process 0.3288547210105502 0.0428639347602333 0.965809998204698 1.0 1.0 5 P21964 1 +Regulation of synaptic vesicle recycling 0.3287055941200523 0.0426463234713139 0.9659834682678308 1.0 1.0 5 Q7L576,Q96CW1,Q4V328,Q9Y263 4 +Cellular potassium ion homeostasis 0.3338775510204038 0.0421861914335766 0.9663502704009894 1.0 1.0 4 P55011,P54709,P05026 3 +Potassium ion import across plasma membrane 0.3338775510204038 0.0421861914335766 0.9663502704009894 1.0 1.0 4 P55011,P54709,P05026 3 +Potassium ion homeostasis 0.3338775510204038 0.0421861914335766 0.9663502704009894 1.0 1.0 4 P55011,P54709,P05026 3 +Post chaperonin tubulin folding pathway 0.389636882904935 0.041761292596414 0.9666889921099496 1.0 1.0 3 O75347,O75695 2 +Regulation of dna dependent dna replication initiation 0.337683523654157 0.0402269199946696 0.9679122159434972 1.0 1.0 2 P24941 1 +Adherens junction maintenance 0.3368678629690035 0.0398435193833172 0.9682178803095448 1.0 1.0 2 Q96AC1 1 +Cell cell junction maintenance 0.3368678629690035 0.0398435193833172 0.9682178803095448 1.0 1.0 2 Q96AC1 1 +Protein methylation 0.2673736011618611 0.039809532775991 0.9682449762011758 1.0 1.0 43 Q9BV86,O60725 2 +Renal water homeostasis 0.385964912280698 0.0390027841602101 0.9688881688654478 1.0 1.0 3 O76024,P17612 2 +Regulation of steroid hormone biosynthetic process 0.333605220228386 0.0383657887098611 0.9693960375436596 1.0 1.0 2 P16435 1 +Regulation of hormone biosynthetic process 0.333605220228386 0.0383657887098611 0.9693960375436596 1.0 1.0 2 P16435 1 +Regulation of heart rate by cardiac conduction 0.3254389546753815 0.0379679574328705 0.9697132298624858 1.0 1.0 5 Q14126,P14923,P62258,P15924 4 +Regulation of cardiac muscle cell action potential 0.3254389546753802 0.0379679574328688 0.9697132298624872 1.0 1.0 5 Q14126,P16615,P14923,P15924 4 +Regulation of cardiac muscle contraction by calcium ion signaling 0.3254389546753802 0.0379679574328688 0.9697132298624872 1.0 1.0 5 P16615,P78417,P05026,P17612 4 +Phospholipid biosynthetic process 0.2711529847389866 0.0376912811587367 0.9699338276861909 1.0 1.0 32 O75874,Q9UG56 2 +Amino acid import across plasma membrane 0.3246222948142105 0.0368246970273469 0.9706247820203804 1.0 1.0 5 P05556,O75915,Q15041,P08195 4 +Regulation of histone phosphorylation 0.3829035844187092 0.0368034490845569 0.9706417239415012 1.0 1.0 3 Q9ULX6 1 +Morphogenesis of a branching structure 0.2889778868922091 0.0363294288577687 0.971019684587509 1.0 1.0 11 P62993,Q9UNS1 2 +Positive regulation of neurotransmitter secretion 0.3283034257748742 0.0361483217523587 0.9711640922972802 1.0 1.0 2 Q15042 1 +Negative regulation of protein localization 0.2701766588006321 0.0359849032453692 0.9712943966232764 1.0 1.0 33 Q16836,Q16850,P40939 3 +Catechol containing compound metabolic process 0.3197105147628428 0.0345838754852745 0.9724115593073634 1.0 1.0 6 P21964 1 +Regulation of rna binding 0.2911661764690025 0.0333349640548248 0.973407471960998 1.0 1.0 8 P60228 1 +Regulation of filopodium assembly 0.2905182042568198 0.0329015827033598 0.973753070665798 1.0 1.0 9 Q06787,P51114,P11233 3 +Torc2 signaling 0.3172920065252863 0.0322141692398468 0.9743012566246784 1.0 1.0 2 Q96A49 1 +Valine metabolic process 0.3208320419662696 0.031655497821627 0.9747467846778776 1.0 1.0 5 O15382,P31937 2 +Ribonucleoprotein complex localization 0.3179051093741795 0.0316230154871339 0.9747726888622265 1.0 1.0 6 Q7KZ85 1 +Protein localization to endoplasmic reticulum exit site 0.3240816326530569 0.0315384347396216 0.9748401408900224 1.0 1.0 4 P51572,O15027,Q92538 3 +Regulation of histone h2b ubiquitination 0.3136215334420895 0.0310872688870848 0.9751999427199364 1.0 1.0 2 Q5VTR2 1 +Sperm capacitation 0.3128058727569293 0.0308484962236362 0.9753903644111676 1.0 1.0 2 P17612 1 +Single strand break repair 0.3123980424143517 0.0307306612914923 0.9754843385299898 1.0 1.0 2 P18887 1 +Non lytic viral release 0.3736232559448429 0.0306739962247768 0.9755295294076268 1.0 1.0 3 Q8WUX9 1 +Regulation of intracellular estrogen receptor signaling pathway 0.2876432078559747 0.028030483046923 0.9776378387381112 1.0 1.0 10 P38398,Q86X55,Q92600,Q99623,Q13309,P09874,O94874,A5YKK6,Q9P253 9 +Carbohydrate transport 0.2835241744401555 0.0276268301776769 0.977959782441987 1.0 1.0 12 P31751,Q99523 2 +Regulation of phosphatidylcholine biosynthetic process 0.3684210526315781 0.0275766811564361 0.9779997803325332 1.0 1.0 3 Q8NF37,P17655 2 +Negative regulation of organ growth 0.3676050591595255 0.0271120427285882 0.9783703695838248 1.0 1.0 3 O94826,P49840 2 +Negative regulation of cell growth involved in cardiac muscle cell development 0.3676050591595255 0.0271120427285882 0.9783703695838248 1.0 1.0 3 O94826,P49840 2 +Negative regulation of cardiac muscle tissue growth 0.3676050591595255 0.0271120427285882 0.9783703695838248 1.0 1.0 3 O94826,P49840 2 +Positive regulation of histone h3 k4 methylation 0.2876021548547617 0.025640517685427 0.979544068243854 1.0 1.0 9 Q9GZS3,Q03164 2 +Regulation of calcium ion dependent exocytosis 0.3156390363413665 0.0249350769452948 0.9801067485691868 1.0 1.0 5 Q00535,P16615,P04899,Q15042 4 +Positive regulation of collagen metabolic process 0.2850734094616609 0.0248765259676768 0.9801534510032596 1.0 1.0 2 P08670 1 +Neuron differentiation 0.2819347869905798 0.0245640803310155 0.9804026703920335 1.0 1.0 167 Q8WUJ1,P50897,Q9NR77,Q9Y639,O14949,P42892,P05067,Q96G23,Q8WWV3,O43464,O60701,O75503,Q8N0X7,Q14108,P41440,P18085,Q9BVA1,Q9UQB8,P18074,P00374,Q9BW83,Q15428,O94788,P04062,Q9Y263,Q15555,Q8NBN7 27 +Modulation by host of viral genome replication 0.3011851246424193 0.0243573806601005 0.9805675435364528 1.0 1.0 7 P35232,P23284,P11142,Q9H1E3,Q06787,Q9H6S0 6 +Chromosome organization involved in meiotic cell cycle 0.2786689717143567 0.0231089927968983 0.9815633323881744 1.0 1.0 13 Q92791,Q9BTX1 2 +Cellular anion homeostasis 0.358589417355015 0.0223449196137555 0.9821728171453092 1.0 1.0 3 P55011 1 +Roof of mouth development 0.3579359442461602 0.0220247098749824 0.982428244686893 1.0 1.0 3 Q92688 1 +Positive regulation of supramolecular fiber organization 0.2680620524342119 0.0220026569854927 0.9824458360840058 1.0 1.0 33 Q9UQB8,P60903,P07737 3 +Regulation of calcium ion transmembrane transporter activity 0.2832906396938337 0.0195181949037079 0.9844277223735058 1.0 1.0 11 P30626,Q06787,P78417 3 +Trna aminoacylation for mitochondrial protein translation 0.3100490196078451 0.0193827638531631 0.984535760279261 1.0 1.0 6 Q6PI48,Q5JTZ9,Q9Y2Z4,Q9BW92,Q9NP81 5 +Glomerular epithelium development 0.35128518971848 0.0189507147150974 0.984880422299346 1.0 1.0 3 P80723,Q12948 2 +Glomerulus development 0.35128518971848 0.0189507147150974 0.984880422299346 1.0 1.0 3 P80723,Q12948 2 +Leukocyte homeostasis 0.2846706885946118 0.0186733347422777 0.9851017003386668 1.0 1.0 8 P04083,P78536,P49069 3 +Positive regulation of response to wounding 0.2980450625238295 0.0185370725267908 0.9852104030409964 1.0 1.0 7 P04083,Q16625 2 +Toll like receptor signaling pathway 0.2828806325328536 0.0183388059918233 0.9853685699606032 1.0 1.0 11 P41440 1 +Positive regulation of receptor internalization 0.3476132190942457 0.0173926953840679 0.9861233365144856 1.0 1.0 3 Q96CW1,Q06787 2 +Gtp metabolic process 0.2838922985540186 0.0166923644993624 0.98668203856064 1.0 1.0 9 Q8IWA4 1 +Amine biosynthetic process 0.3071729587249149 0.0161320115348793 0.9871290753228066 1.0 1.0 4 P05091 1 +Apoptotic process involved in development 0.3439412484700098 0.0159290149327421 0.9872910223675708 1.0 1.0 3 Q12948,O94813 2 +Regulation of superoxide anion generation 0.3430427058420169 0.0155847953275259 0.9875656357821094 1.0 1.0 3 P04899 1 +Regulation of b cell proliferation 0.3423092615259045 0.0153078092424978 0.9877866123394264 1.0 1.0 3 P14174,P02786 2 +Positive regulation of b cell proliferation 0.3423092615259045 0.0153078092424978 0.9877866123394264 1.0 1.0 3 P14174,P02786 2 +Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 0.3423092615259033 0.0153078092424972 0.9877866123394268 1.0 1.0 3 O60341,P14174 2 +Regulation of electron transfer activity 0.3414932680538519 0.0150038210271511 0.9880291319873564 1.0 1.0 3 O00483,Q99623 2 +Morphogenesis of embryonic epithelium 0.2739736401945234 0.0140000047580912 0.9888299772412024 1.0 1.0 19 O94788,P07737 2 +Trophectodermal cell differentiation 0.3040816326530555 0.0136985911593082 0.9890704474346126 1.0 1.0 4 O75175,Q13895,A5YKK6 3 +Regulation of protein containing complex disassembly 0.2654819762685701 0.0135210498510335 0.989212091784402 1.0 1.0 38 P04062,O75844,Q9UHB6 3 +Toxin transport 0.2811565404871635 0.0134277576550731 0.9892865214301618 1.0 1.0 11 Q93050 1 +Regulation of blood brain barrier permeability 0.3370053039575675 0.0134086723536376 0.9893017479266996 1.0 1.0 3 Q16625,Q9UDY2 2 +Positive regulation of blood brain barrier permeability 0.3370053039575675 0.0134086723536376 0.9893017479266996 1.0 1.0 3 Q16625,Q9UDY2 2 +Positive regulation of vascular permeability 0.3370053039575675 0.0134086723536376 0.9893017479266996 1.0 1.0 3 Q16625,Q9UDY2 2 +Escrt complex disassembly 0.3353733170134623 0.0128599839331165 0.9897395001805588 1.0 1.0 3 P53990,Q8WUX9 2 +Positive regulation of transmembrane transport 0.2714777762669714 0.0116006470471866 0.9907442304254088 1.0 1.0 22 P31751,P30626,Q15041,P08183 4 +Regulation of ras protein signal transduction 0.2703776924626352 0.0113982487211759 0.9909057102474086 1.0 1.0 23 P41440,Q15555,P37198,Q13501 4 +Positive regulation of neurotransmitter transport 0.3284373725010173 0.0107051992796933 0.9914586499163516 1.0 1.0 3 P05556,Q15042 2 +Negative regulation of sodium ion transport 0.325173398612809 0.0097856550644399 0.992192301516565 1.0 1.0 3 O14745,Q96PU5 2 +Negative regulation of sodium ion transmembrane transport 0.325173398612809 0.0097856550644399 0.992192301516565 1.0 1.0 3 O14745,Q96PU5 2 +L aspartate transmembrane transport 0.324357405140752 0.0095647767001185 0.992368528704425 1.0 1.0 3 Q9UJS0,O75746 2 +Negative regulation of cell cell adhesion 0.2776946400178584 0.0091945142506087 0.9926639423994448 1.0 1.0 12 P04083,Q96J02 2 +Pyrimidine containing compound biosynthetic process 0.2774989100441765 0.0085921132575117 0.993144569836947 1.0 1.0 12 P23919,P15531,P17812,P04818 4 +Negative regulation of protein serine threonine kinase activity 0.2744161920404059 0.008461585911396 0.993248711805099 1.0 1.0 13 P04062,P37198 2 +Protein localization to vacuole 0.2743777516068237 0.0083316424938524 0.9933523879968496 1.0 1.0 13 Q14108 1 +Axonal transport of mitochondrion 0.295102040816321 0.0072567552234689 0.9942099978631108 1.0 1.0 4 P27695,O60313,Q9UH62 3 +Positive regulation of rna export from nucleus 0.3148317877403469 0.0072371011257137 0.994225679152486 1.0 1.0 3 Q16630 1 +Positive regulation of nucleobase containing compound transport 0.3148317877403469 0.0072371011257137 0.994225679152486 1.0 1.0 3 Q16630 1 +Anterior posterior axis specification 0.2943814639435831 0.0067788623994975 0.9945912917760382 1.0 1.0 4 P80723 1 +Embryonic axis specification 0.2943814639435831 0.0067788623994975 0.9945912917760382 1.0 1.0 4 P80723 1 +Embryonic pattern specification 0.2943814639435831 0.0067788623994975 0.9945912917760382 1.0 1.0 4 P80723 1 +Response to zinc ion 0.3125254997959972 0.0067390207048244 0.9946230801229856 1.0 1.0 3 P04179,P09960 2 +Negative regulation of cell development 0.2725756698732473 0.006533160108879 0.9947873294972562 1.0 1.0 18 Q96G23,Q8IXJ6 2 +Positive regulation of translation 0.2550574227620336 0.0062861356571596 0.9949844224442388 1.0 1.0 51 Q14011,P60228,P08670,Q7Z739,Q96P11,Q567V2,Q92552,O60506,Q13217,Q9Y2R0,Q06787,Q07021,Q14103,P56537 14 +Production of molecular mediator of immune response 0.2670157673787624 0.0057510315212037 0.9954113660349128 1.0 1.0 30 P09601 1 +Skeletal muscle cell differentiation 0.2998366013071917 0.0050132926559336 0.9959999879465038 1.0 1.0 6 P17844,P50402,P61201,Q9BYT8,Q92841 5 +Protein polyufmylation 0.2868217054263536 0.0026205733970895 0.9979090873392024 1.0 1.0 3 O94874,Q9Y3C8 2 +Reticulophagy 0.2868217054263536 0.0026205733970895 0.9979090873392024 1.0 1.0 3 O94874,Q9Y3C8 2 +Positive regulation of calcium ion transmembrane transport 0.2887937387008241 0.0025070338936163 0.997999678458284 1.0 1.0 7 P30626 1 +Regulation of collagen metabolic process 0.28518971848225 0.0024344065971862 0.9980576264799148 1.0 1.0 3 P05556,P08670 2 +Positive regulation of calcium ion transport 0.2772923223137792 0.0015785411469383 0.9987405069133316 1.0 1.0 9 P30626 1 diff --git a/msigdb_gobp/selections.json b/msigdb_gobp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..b855c94603f37cacb8b41d9671d09585f08f9f44 --- /dev/null +++ b/msigdb_gobp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["10 formyltetrahydrofolate metabolic process", "2 oxoglutarate metabolic process", "2fe 2s cluster assembly", "3 phosphoadenosine 5 phosphosulfate biosynthetic process", "3 phosphoadenosine 5 phosphosulfate metabolic process", "3 utr mediated mrna destabilization", "3 utr mediated mrna stabilization", "5 phosphoribose 1 diphosphate metabolic process", "5s class rrna transcription by rna polymerase iii", "Abscission", "Acetyl coa biosynthetic process", "Acetyl coa biosynthetic process from pyruvate", "Acetyl coa metabolic process", "Acid secretion", "Acidic amino acid transport", "Acrosome assembly", "Actin crosslink formation", "Actin cytoskeleton reorganization", "Actin filament based movement", "Actin filament based process", "Actin filament based transport", "Actin filament bundle organization", "Actin filament depolymerization", "Actin filament network formation", "Actin filament organization", "Actin filament polymerization", "Actin filament severing", "Actin mediated cell contraction", "Actin modification", "Actin myosin filament sliding", "Actin nucleation", "Actin polymerization dependent cell motility", "Actin polymerization or depolymerization", "Action potential", "Activated t cell proliferation", "Activation induced cell death of t cells", "Activation of adenylate cyclase activity", "Activation of cysteine type endopeptidase activity", "Activation of cysteine type endopeptidase activity involved in apoptotic process", "Activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome c", "Activation of gtpase activity", "Activation of immune response", "Activation of innate immune response", "Activation of nf kappab inducing kinase activity", "Activation of phospholipase c activity", "Activation of phospholipase d activity", "Activation of protein kinase activity", "Activation of protein kinase b activity", "Activation of protein kinase c activity", "Activin receptor signaling pathway", "Actomyosin contractile ring organization", "Actomyosin structure organization", "Acute inflammatory response", "Acute inflammatory response to antigenic stimulus", "Acute phase response", "Acyl carnitine transmembrane transport", "Acylglycerol homeostasis", "Adaptation of signaling pathway", "Adaptive immune response", "Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", "Adaptive thermogenesis", "Adenosine metabolic process", "Adenosine to inosine editing", "Adenylate cyclase activating adrenergic receptor signaling pathway", "Adenylate cyclase activating adrenergic receptor signaling pathway involved in heart process", "Adenylate cyclase activating dopamine receptor signaling pathway", "Adenylate cyclase activating g protein coupled receptor signaling pathway", "Adenylate cyclase inhibiting dopamine receptor signaling pathway", "Adenylate cyclase inhibiting g protein coupled receptor signaling pathway", "Adenylate cyclase modulating g protein coupled receptor signaling pathway", "Adherens junction assembly", "Adherens junction maintenance", "Adherens junction organization", "Adhesion of symbiont to host", "Adhesion of symbiont to host cell", "Adiponectin activated signaling pathway", "Adipose tissue development", "Adp biosynthetic process", "Adp metabolic process", "Adp transport", "Adrenergic receptor signaling pathway", "Adult behavior", "Adult locomotory behavior", "Aerobic respiration", "Aggrephagy", "Aggresome assembly", "Aging", "Alanine transport", "Alcohol biosynthetic process", "Alcohol catabolic process", "Alcohol metabolic process", "Aldehyde biosynthetic process", "Aldehyde catabolic process", "Alditol biosynthetic process", "Alditol catabolic process", "Alditol metabolic process", "Alditol phosphate metabolic process", "Alkanesulfonate metabolic process", "Allantoin metabolic process", "Alpha amino acid catabolic process", "Alpha amino acid metabolic process", "Alpha beta t cell activation", "Alpha beta t cell differentiation", "Alpha beta t cell proliferation", "Alpha ketoglutarate transport", "Alpha linolenic acid metabolic process", "Alternative mrna splicing via spliceosome", "Ameboidal type cell migration", "Amelogenesis", "Amide biosynthetic process", "Amide transport", "Amine biosynthetic process", "Amine catabolic process", "Amine metabolic process", "Amine transport", "Amino acid activation", "Amino acid betaine biosynthetic process", "Amino acid betaine metabolic process", "Amino acid betaine transport", "Amino acid homeostasis", "Amino acid import", "Amino acid import across plasma membrane", "Amino acid neurotransmitter reuptake", "Amino acid salvage", "Amino acid transmembrane transport", "Amino acid transport", "Amino sugar biosynthetic process", "Amino sugar catabolic process", "Amino sugar metabolic process", "Aminoacyl trna metabolism involved in translational fidelity", "Aminoglycan biosynthetic process", "Aminoglycan catabolic process", "Aminoglycan metabolic process", "Aminoglycoside antibiotic metabolic process", "Aminophospholipid transport", "Ammonium ion metabolic process", "Ammonium transmembrane transport", "Amp biosynthetic process", "Amp metabolic process", "Amp salvage", "Ampa glutamate receptor clustering", "Amygdala development", "Amyloid beta clearance", "Amyloid beta clearance by cellular catabolic process", "Amyloid beta clearance by transcytosis", "Amyloid beta formation", "Amyloid beta metabolic process", "Amyloid fibril formation", "Amyloid precursor protein biosynthetic process", "Amyloid precursor protein catabolic process", "Amyloid precursor protein metabolic process", "Anagen", "Anaphase promoting complex dependent catabolic process", "Anatomical structure arrangement", "Anatomical structure formation involved in morphogenesis", "Anatomical structure homeostasis", "Anatomical structure maturation", "Androgen metabolic process", "Androgen receptor signaling pathway", "Angiogenesis involved in wound healing", "Angiotensin activated signaling pathway", "Animal organ formation", "Animal organ maturation", "Animal organ morphogenesis", "Animal organ regeneration", "Anion homeostasis", "Anion transmembrane transport", "Anion transport", "Anoikis", "Anterior head development", "Anterior posterior axis specification", "Anterior posterior pattern specification", "Anterograde axonal transport", "Anterograde axonal transport of mitochondrion", "Anterograde dendritic transport", "Anterograde dendritic transport of neurotransmitter receptor complex", "Anterograde neuronal dense core vesicle transport", "Antibacterial humoral response", "Antigen processing and presentation", "Antigen processing and presentation of endogenous antigen", "Antigen processing and presentation of endogenous peptide antigen", "Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway", "Antigen processing and presentation of exogenous antigen", "Antigen processing and presentation of exogenous peptide antigen", "Antigen processing and presentation of exogenous peptide antigen via mhc class i", "Antigen processing and presentation of exogenous peptide antigen via mhc class ii", "Antigen processing and presentation of lipid antigen via mhc class ib", "Antigen processing and presentation of peptide antigen", "Antigen processing and presentation of peptide antigen via mhc class i", "Antigen processing and presentation of peptide antigen via mhc class ib", "Antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii", "Antigen processing and presentation via mhc class ib", "Antigen receptor mediated signaling pathway", "Antimicrobial humoral immune response mediated by antimicrobial peptide", "Antimicrobial humoral response", "Antiviral innate immune response", "Aorta development", "Aorta morphogenesis", "Aortic valve morphogenesis", "Apical junction assembly", "Apical protein localization", "Apolipoprotein a i mediated signaling pathway", "Apoptotic cell clearance", "Apoptotic chromosome condensation", "Apoptotic dna fragmentation", "Apoptotic mitochondrial changes", "Apoptotic process involved in development", "Apoptotic process involved in heart morphogenesis", "Apoptotic process involved in morphogenesis", "Apoptotic signaling pathway", "Appendage development", "Appendage morphogenesis", "Arachidonic acid metabolic process", "Arachidonic acid secretion", "Arf protein signal transduction", "Arginine catabolic process", "Arginine metabolic process", "Aromatic amino acid family catabolic process", "Aromatic amino acid family metabolic process", "Aromatic amino acid transport", "Arp2 3 complex mediated actin nucleation", "Artery development", "Artery morphogenesis", "Asparagine metabolic process", "Aspartate family amino acid biosynthetic process", "Aspartate family amino acid catabolic process", "Aspartate family amino acid metabolic process", "Aspartate metabolic process", "Aspartate transmembrane transport", "Associative learning", "Astral microtubule organization", "Astrocyte activation", "Astrocyte cell migration", "Astrocyte development", "Astrocyte differentiation", "Asymmetric cell division", "Asymmetric neuroblast division", "Atf6 mediated unfolded protein response", "Atp biosynthetic process", "Atp metabolic process", "Atp synthesis coupled electron transport", "Atp synthesis coupled proton transport", "Atp transport", "Atrial cardiac muscle cell membrane repolarization", "Atrial cardiac muscle cell to av node cell signaling", "Atrial septum development", "Atrial septum morphogenesis", "Attachment of gpi anchor to protein", "Attachment of mitotic spindle microtubules to kinetochore", "Attachment of spindle microtubules to kinetochore", "Auditory receptor cell development", "Auditory receptor cell morphogenesis", "Autonomic nervous system development", "Autophagic cell death", "Autophagosome maturation", "Autophagosome membrane docking", "Autophagosome organization", "Autophagy of mitochondrion", "Autophagy of nucleus", "Axial mesoderm development", "Axis elongation", "Axis specification", "Axo dendritic protein transport", "Axo dendritic transport", "Axon choice point recognition", "Axon development", "Axon ensheathment in central nervous system", "Axon extension", "Axon midline choice point recognition", "Axonal fasciculation", "Axonal transport", "Axonal transport of mitochondrion", "Axonemal dynein complex assembly", "Axoneme assembly", "Axonogenesis involved in innervation", "Azole transmembrane transport", "B cell activation", "B cell activation involved in immune response", "B cell apoptotic process", "B cell differentiation", "B cell homeostasis", "B cell lineage commitment", "B cell mediated immunity", "B cell proliferation", "Barbed end actin filament capping", "Base conversion or substitution editing", "Base excision repair", "Base excision repair ap site formation", "Base excision repair gap filling", "Basement membrane assembly", "Basement membrane organization", "Behavior", "Behavioral response to cocaine", "Behavioral response to ethanol", "Behavioral response to pain", "Benzene containing compound metabolic process", "Bergmann glial cell differentiation", "Bicarbonate transport", "Bile acid and bile salt transport", "Bile acid biosynthetic process", "Bile acid metabolic process", "Bile acid secretion", "Binding of sperm to zona pellucida", "Biological adhesion", "Biological phase", "Biological process involved in interaction with host", "Biological process involved in interaction with symbiont", "Biological process involved in interspecies interaction between organisms", "Biological process involved in intraspecies interaction between organisms", "Biological process involved in symbiotic interaction", "Biomineralization", "Blastocyst development", "Blastocyst formation", "Blastocyst growth", "Blastoderm segmentation", "Bleb assembly", "Blood vessel endothelial cell migration", "Blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Blood vessel maturation", "Blood vessel morphogenesis", "Blood vessel remodeling", "Body fluid secretion", "Body morphogenesis", "Bone cell development", "Bone development", "Bone growth", "Bone marrow development", "Bone maturation", "Bone mineralization", "Bone morphogenesis", "Bone remodeling", "Bone resorption", "Box c d snornp assembly", "Bradykinin catabolic process", "Brain morphogenesis", "Brainstem development", "Branched chain amino acid biosynthetic process", "Branched chain amino acid catabolic process", "Branched chain amino acid metabolic process", "Branched chain amino acid transport", "Branching involved in blood vessel morphogenesis", "Branching involved in labyrinthine layer morphogenesis", "Branching involved in mammary gland duct morphogenesis", "Branching morphogenesis of a nerve", "Branching morphogenesis of an epithelial tube", "Brown fat cell differentiation", "Bundle of his cell to purkinje myocyte communication", "C 5 methylation of cytosine", "C terminal protein amino acid modification", "C21 steroid hormone biosynthetic process", "C21 steroid hormone metabolic process", "C4 dicarboxylate transport", "Calcineurin mediated signaling", "Calcium import into the mitochondrion", "Calcium ion export", "Calcium ion export across plasma membrane", "Calcium ion import", "Calcium ion import into cytosol", "Calcium ion import into sarcoplasmic reticulum", "Calcium ion regulated exocytosis", "Calcium ion regulated exocytosis of neurotransmitter", "Calcium ion transmembrane transport", "Calcium ion transmembrane transport via high voltage gated calcium channel", "Calcium ion transport", "Calcium ion transport into cytosol", "Calcium mediated signaling", "Calcium mediated signaling using intracellular calcium source", "Calmodulin dependent kinase signaling pathway", "Camera type eye development", "Camera type eye morphogenesis", "Camera type eye photoreceptor cell differentiation", "Camp mediated signaling", "Cannabinoid signaling pathway", "Canonical wnt signaling pathway", "Canonical wnt signaling pathway involved in heart development", "Canonical wnt signaling pathway involved in osteoblast differentiation", "Canonical wnt signaling pathway involved in regulation of cell proliferation", "Cap dependent translational initiation", "Carbohydrate biosynthetic process", "Carbohydrate catabolic process", "Carbohydrate derivative biosynthetic process", "Carbohydrate derivative catabolic process", "Carbohydrate derivative metabolic process", "Carbohydrate derivative transport", "Carbohydrate homeostasis", "Carbohydrate mediated signaling", "Carbohydrate metabolic process", "Carbohydrate phosphorylation", "Carbohydrate transmembrane transport", "Carbohydrate transport", "Carboxylic acid transport", "Cardiac atrium development", "Cardiac atrium morphogenesis", "Cardiac cell development", "Cardiac chamber development", "Cardiac chamber morphogenesis", "Cardiac conduction", "Cardiac conduction system development", "Cardiac epithelial to mesenchymal transition", "Cardiac left ventricle morphogenesis", "Cardiac muscle cell action potential", "Cardiac muscle cell action potential involved in contraction", "Cardiac muscle cell cardiac muscle cell adhesion", "Cardiac muscle cell contraction", "Cardiac muscle cell differentiation", "Cardiac muscle cell membrane repolarization", "Cardiac muscle cell proliferation", "Cardiac muscle contraction", "Cardiac muscle tissue development", "Cardiac muscle tissue morphogenesis", "Cardiac neural crest cell development involved in outflow tract morphogenesis", "Cardiac neural crest cell differentiation involved in heart development", "Cardiac neural crest cell migration involved in outflow tract morphogenesis", "Cardiac septum development", "Cardiac septum morphogenesis", "Cardiac ventricle development", "Cardiac ventricle morphogenesis", "Cardioblast differentiation", "Cardioblast proliferation", "Cardiocyte differentiation", "Cardiolipin acyl chain remodeling", "Cardiolipin biosynthetic process", "Cardiolipin metabolic process", "Carnitine metabolic process", "Carnitine transport", "Cartilage development", "Cartilage development involved in endochondral bone morphogenesis", "Catechol containing compound biosynthetic process", "Catechol containing compound catabolic process", "Catechol containing compound metabolic process", "Catecholamine uptake", "Catecholamine uptake involved in synaptic transmission", "Cation transmembrane transport", "Cation transport", "Caveola assembly", "Caveolin mediated endocytosis", "Cd4 positive alpha beta t cell activation", "Cd4 positive alpha beta t cell differentiation", "Cd4 positive alpha beta t cell proliferation", "Cd4 positive or cd8 positive alpha beta t cell lineage commitment", "Cd40 signaling pathway", "Cd8 positive alpha beta t cell activation", "Cd8 positive alpha beta t cell proliferation", "Cdc42 protein signal transduction", "Cdp choline pathway", "Cdp diacylglycerol metabolic process", "Cell activation", "Cell activation involved in immune response", "Cell adhesion mediated by integrin", "Cell adhesion molecule production", "Cell aging", "Cell cell adhesion", "Cell cell adhesion mediated by cadherin", "Cell cell adhesion mediated by integrin", "Cell cell adhesion via plasma membrane adhesion molecules", "Cell cell junction assembly", "Cell cell junction maintenance", "Cell cell junction organization", "Cell cell recognition", "Cell cell signaling", "Cell cell signaling by wnt", "Cell cell signaling involved in cardiac conduction", "Cell chemotaxis", "Cell communication by electrical coupling", "Cell communication by electrical coupling involved in cardiac conduction", "Cell communication involved in cardiac conduction", "Cell cycle", "Cell cycle checkpoint signaling", "Cell cycle dna replication", "Cell cycle dna replication initiation", "Cell cycle g1 s phase transition", "Cell cycle g2 m phase transition", "Cell cycle phase transition", "Cell cycle process", "Cell death in response to hydrogen peroxide", "Cell death in response to oxidative stress", "Cell differentiation in hindbrain", "Cell differentiation in spinal cord", "Cell differentiation involved in embryonic placenta development", "Cell differentiation involved in kidney development", "Cell differentiation involved in metanephros development", "Cell differentiation involved in phenotypic switching", "Cell division", "Cell fate commitment", "Cell fate commitment involved in formation of primary germ layer", "Cell fate determination", "Cell fate specification", "Cell growth", "Cell junction assembly", "Cell junction disassembly", "Cell junction maintenance", "Cell junction organization", "Cell killing", "Cell matrix adhesion", "Cell maturation", "Cell migration", "Cell migration in hindbrain", "Cell migration involved in gastrulation", "Cell migration involved in heart development", "Cell migration involved in sprouting angiogenesis", "Cell morphogenesis", "Cell morphogenesis involved in differentiation", "Cell morphogenesis involved in neuron differentiation", "Cell motility involved in cerebral cortex radial glia guided migration", "Cell part morphogenesis", "Cell projection assembly", "Cell projection organization", "Cell proliferation in forebrain", "Cell proliferation in hindbrain", "Cell proliferation involved in heart morphogenesis", "Cell recognition", "Cell redox homeostasis", "Cell substrate adhesion", "Cell substrate junction organization", "Cell surface receptor signaling pathway involved in cell cell signaling", "Cell surface receptor signaling pathway involved in heart development", "Cell volume homeostasis", "Cellular aldehyde metabolic process", "Cellular amide metabolic process", "Cellular amino acid biosynthetic process", "Cellular amino acid catabolic process", "Cellular amino acid metabolic process", "Cellular anion homeostasis", "Cellular carbohydrate biosynthetic process", "Cellular carbohydrate catabolic process", "Cellular carbohydrate metabolic process", "Cellular component assembly involved in morphogenesis", "Cellular component disassembly", "Cellular component disassembly involved in execution phase of apoptosis", "Cellular component maintenance", "Cellular component morphogenesis", "Cellular copper ion homeostasis", "Cellular defense response", "Cellular detoxification of aldehyde", "Cellular extravasation", "Cellular glucan metabolic process", "Cellular glucose homeostasis", "Cellular homeostasis", "Cellular hormone metabolic process", "Cellular hyperosmotic response", "Cellular hyperosmotic salinity response", "Cellular ion homeostasis", "Cellular iron ion homeostasis", "Cellular ketone metabolic process", "Cellular lipid catabolic process", "Cellular lipid metabolic process", "Cellular macromolecule biosynthetic process", "Cellular macromolecule localization", "Cellular metabolic compound salvage", "Cellular modified amino acid biosynthetic process", "Cellular modified amino acid catabolic process", "Cellular modified amino acid metabolic process", "Cellular monovalent inorganic anion homeostasis", "Cellular monovalent inorganic cation homeostasis", "Cellular nitrogen compound catabolic process", "Cellular oxidant detoxification", "Cellular pigmentation", "Cellular polysaccharide catabolic process", "Cellular potassium ion homeostasis", "Cellular process involved in reproduction in multicellular organism", "Cellular protein catabolic process", "Cellular respiration", "Cellular response to abiotic stimulus", "Cellular response to acid chemical", "Cellular response to acidic ph", "Cellular response to alcohol", "Cellular response to aldehyde", "Cellular response to alkaloid", "Cellular response to amyloid beta", "Cellular response to antibiotic", "Cellular response to arsenic containing substance", "Cellular response to atp", "Cellular response to biotic stimulus", "Cellular response to brain derived neurotrophic factor stimulus", "Cellular response to cadmium ion", "Cellular response to calcium ion", "Cellular response to camp", "Cellular response to carbohydrate stimulus", "Cellular response to chemical stress", "Cellular response to cold", "Cellular response to copper ion", "Cellular response to corticosteroid stimulus", "Cellular response to dexamethasone stimulus", "Cellular response to dna damage stimulus", "Cellular response to dsrna", "Cellular response to electrical stimulus", "Cellular response to endogenous stimulus", "Cellular response to epinephrine stimulus", "Cellular response to estradiol stimulus", "Cellular response to estrogen stimulus", "Cellular response to ethanol", "Cellular response to ether", "Cellular response to exogenous dsrna", "Cellular response to external stimulus", "Cellular response to extracellular stimulus", "Cellular response to fatty acid", "Cellular response to fluid shear stress", "Cellular response to follicle stimulating hormone stimulus", "Cellular response to gamma radiation", "Cellular response to glucose starvation", "Cellular response to gonadotropin stimulus", "Cellular response to growth hormone stimulus", "Cellular response to heat", "Cellular response to heparin", "Cellular response to histamine", "Cellular response to hormone stimulus", "Cellular response to hydrogen peroxide", "Cellular response to hyperoxia", "Cellular response to increased oxygen levels", "Cellular response to indole 3 methanol", "Cellular response to inorganic substance", "Cellular response to insulin like growth factor stimulus", "Cellular response to insulin stimulus", "Cellular response to interferon alpha", "Cellular response to interferon beta", "Cellular response to interferon gamma", "Cellular response to interleukin 1", "Cellular response to ionizing radiation", "Cellular response to iron ion", "Cellular response to ketone", "Cellular response to leptin stimulus", "Cellular response to leucine", "Cellular response to leucine starvation", "Cellular response to light intensity", "Cellular response to light stimulus", "Cellular response to lipid", "Cellular response to lipoprotein particle stimulus", "Cellular response to lithium ion", "Cellular response to low density lipoprotein particle stimulus", "Cellular response to magnesium ion", "Cellular response to manganese ion", "Cellular response to mechanical stimulus", "Cellular response to mineralocorticoid stimulus", "Cellular response to molecule of bacterial origin", "Cellular response to muramyl dipeptide", "Cellular response to nitrogen compound", "Cellular response to nitrosative stress", "Cellular response to nutrient", "Cellular response to organic cyclic compound", "Cellular response to osmotic stress", "Cellular response to oxidised low density lipoprotein particle stimulus", "Cellular response to oxygen containing compound", "Cellular response to oxygen glucose deprivation", "Cellular response to oxygen levels", "Cellular response to oxygen radical", "Cellular response to parathyroid hormone stimulus", "Cellular response to peptide", "Cellular response to peptide hormone stimulus", "Cellular response to peptidoglycan", "Cellular response to ph", "Cellular response to potassium ion", "Cellular response to prostaglandin e stimulus", "Cellular response to prostaglandin stimulus", "Cellular response to radiation", "Cellular response to reactive nitrogen species", "Cellular response to reactive oxygen species", "Cellular response to retinoic acid", "Cellular response to salt", "Cellular response to salt stress", "Cellular response to sodium arsenite", "Cellular response to starvation", "Cellular response to steroid hormone stimulus", "Cellular response to sterol depletion", "Cellular response to stress", "Cellular response to testosterone stimulus", "Cellular response to thyroid hormone stimulus", "Cellular response to topologically incorrect protein", "Cellular response to toxic substance", "Cellular response to unfolded protein", "Cellular response to uv", "Cellular response to uv a", "Cellular response to uv c", "Cellular response to vascular endothelial growth factor stimulus", "Cellular response to virus", "Cellular response to vitamin", "Cellular response to vitamin d", "Cellular response to water stimulus", "Cellular response to x ray", "Cellular response to xenobiotic stimulus", "Cellular response to zinc ion", "Cellular senescence", "Cellular sodium ion homeostasis", "Cellular sphingolipid homeostasis", "Cellular transition metal ion homeostasis", "Cellular triglyceride homeostasis", "Cellular trivalent inorganic anion homeostasis", "Cenp a containing chromatin organization", "Central nervous system development", "Central nervous system maturation", "Central nervous system myelin formation", "Central nervous system neuron axonogenesis", "Central nervous system neuron development", "Central nervous system neuron differentiation", "Central nervous system projection neuron axonogenesis", "Centriole assembly", "Centriole centriole cohesion", "Centriole elongation", "Centromere complex assembly", "Centromeric sister chromatid cohesion", "Centrosome duplication", "Centrosome separation", "Ceramide biosynthetic process", "Ceramide catabolic process", "Ceramide metabolic process", "Ceramide transport", "Cerebellar cortex development", "Cerebellar cortex formation", "Cerebellar cortex morphogenesis", "Cerebellar granular layer development", "Cerebellar granular layer formation", "Cerebellar granular layer morphogenesis", "Cerebellar purkinje cell layer development", "Cerebellar purkinje cell layer formation", "Cerebellar purkinje cell layer morphogenesis", "Cerebral cortex cell migration", "Cerebral cortex development", "Cerebral cortex neuron differentiation", "Cerebral cortex radially oriented cell migration", "Cerebral cortex regionalization", "Cerebral cortex tangential migration", "Cerebrospinal fluid circulation", "Cgmp mediated signaling", "Changes to dna methylation involved in embryo development", "Chaperone cofactor dependent protein refolding", "Chaperone mediated autophagy", "Chaperone mediated protein complex assembly", "Chaperone mediated protein folding", "Chemical homeostasis", "Chemical homeostasis within a tissue", "Chemical synaptic transmission postsynaptic", "Chemokine c c motif ligand 5 production", "Chemokine c x c motif ligand 2 production", "Chemokine production", "Chemosensory behavior", "Chloride transmembrane transport", "Chloride transport", "Cholesterol catabolic process", "Cholesterol efflux", "Cholesterol storage", "Choline metabolic process", "Chondrocyte development", "Chondrocyte development involved in endochondral bone morphogenesis", "Chondrocyte differentiation", "Chondrocyte differentiation involved in endochondral bone morphogenesis", "Chondrocyte proliferation", "Chondroitin sulfate biosynthetic process", "Chondroitin sulfate proteoglycan biosynthetic process", "Chondroitin sulfate proteoglycan metabolic process", "Chromatin assembly or disassembly", "Chromatin disassembly", "Chromatin organization", "Chromatin remodeling", "Chromatin remodeling at centromere", "Chromosome attachment to the nuclear envelope", "Chromosome condensation", "Chromosome localization", "Chromosome movement towards spindle pole", "Chromosome organization", "Chromosome organization involved in meiotic cell cycle", "Chromosome segregation", "Chromosome separation", "Cilium movement", "Cilium or flagellum dependent cell motility", "Cilium organization", "Circadian regulation of gene expression", "Circadian rhythm", "Circulatory system development", "Circulatory system process", "Citrate metabolic process", "Citrulline biosynthetic process", "Citrulline metabolic process", "Clathrin coat assembly", "Clathrin dependent endocytosis", "Cleavage furrow formation", "Cleavage involved in rrna processing", "Cobalamin metabolic process", "Cobalt ion transport", "Cochlea development", "Cochlea morphogenesis", "Coenzyme a biosynthetic process", "Coenzyme a metabolic process", "Cognition", "Cohesin loading", "Collagen biosynthetic process", "Collagen catabolic process", "Collagen fibril organization", "Collagen metabolic process", "Collateral sprouting", "Collateral sprouting in absence of injury", "Collecting duct development", "Columnar cuboidal epithelial cell development", "Columnar cuboidal epithelial cell differentiation", "Columnar cuboidal epithelial cell maturation", "Common partner smad protein phosphorylation", "Complement activation", "Complement dependent cytotoxicity", "Connective tissue development", "Connective tissue replacement", "Constitutive heterochromatin assembly", "Constitutive secretory pathway", "Convergent extension", "Convergent extension involved in axis elongation", "Cop9 signalosome assembly", "Copi coated vesicle budding", "Copii coated vesicle budding", "Copii coated vesicle cargo loading", "Copper ion homeostasis", "Copper ion import", "Copper ion transport", "Coronary artery morphogenesis", "Coronary vasculature development", "Coronary vasculature morphogenesis", "Corpus callosum development", "Corpus callosum morphogenesis", "Cortical actin cytoskeleton organization", "Cortical cytoskeleton organization", "Corticospinal tract morphogenesis", "Corticosteroid receptor signaling pathway", "Cotranslational protein targeting to membrane", "Cranial ganglion development", "Cranial nerve development", "Cranial skeletal system development", "Crd mediated mrna stabilization", "Cristae formation", "Cyclic gmp amp transmembrane import across plasma membrane", "Cyclic nucleotide catabolic process", "Cyclic nucleotide mediated signaling", "Cyclic nucleotide metabolic process", "Cyclooxygenase pathway", "Cysteine metabolic process", "Cytochrome complex assembly", "Cytokine mediated signaling pathway", "Cytokine production", "Cytokine production involved in immune response", "Cytokine production involved in inflammatory response", "Cytokinesis", "Cytokinetic process", "Cytoplasm organization", "Cytoplasmic microtubule organization", "Cytoplasmic pattern recognition receptor signaling pathway", "Cytoplasmic pattern recognition receptor signaling pathway in response to virus", "Cytoplasmic sequestering of nf kappab", "Cytoplasmic sequestering of protein", "Cytoplasmic sequestering of transcription factor", "Cytoplasmic translation", "Cytoplasmic translational elongation", "Cytoplasmic translational initiation", "Cytoskeleton dependent cytokinesis", "Cytoskeleton dependent intracellular transport", "Cytoskeleton organization", "Cytosolic calcium ion transport", "Cytosolic transport", "D amino acid transport", "Damp metabolic process", "De novo amp biosynthetic process", "De novo protein folding", "De novo pyrimidine nucleobase biosynthetic process", "Deadenylation dependent decapping of nuclear transcribed mrna", "Decidualization", "Dedifferentiation", "Defense response", "Defense response to bacterium", "Defense response to fungus", "Defense response to gram negative bacterium", "Defense response to gram positive bacterium", "Defense response to other organism", "Defense response to symbiont", "Defense response to tumor cell", "Definitive erythrocyte differentiation", "Definitive hemopoiesis", "Demethylation", "Dendrite arborization", "Dendrite development", "Dendrite extension", "Dendrite morphogenesis", "Dendrite self avoidance", "Dendritic cell chemotaxis", "Dendritic cell cytokine production", "Dendritic cell differentiation", "Dendritic cell migration", "Dendritic spine development", "Dendritic spine maintenance", "Dendritic spine morphogenesis", "Dendritic transport", "Dense core granule transport", "Dentate gyrus development", "Deoxyribonucleoside catabolic process", "Deoxyribonucleoside diphosphate metabolic process", "Deoxyribonucleoside metabolic process", "Deoxyribonucleoside monophosphate biosynthetic process", "Deoxyribonucleoside monophosphate catabolic process", "Deoxyribonucleoside monophosphate metabolic process", "Deoxyribonucleoside triphosphate biosynthetic process", "Deoxyribonucleoside triphosphate catabolic process", "Deoxyribonucleoside triphosphate metabolic process", "Deoxyribonucleotide biosynthetic process", "Deoxyribose phosphate catabolic process", "Deoxyribose phosphate metabolic process", "Dephosphorylation", "Dephosphorylation of rna polymerase ii c terminal domain", "Depyrimidination", "Dermatan sulfate biosynthetic process", "Dermatan sulfate metabolic process", "Dermatan sulfate proteoglycan metabolic process", "Desmosome organization", "Detection of abiotic stimulus", "Detection of biotic stimulus", "Detection of external biotic stimulus", "Detection of light stimulus", "Detection of mechanical stimulus", "Detection of molecule of bacterial origin", "Detection of muscle stretch", "Detection of other organism", "Detection of stimulus", "Detection of virus", "Detection of visible light", "Determination of adult lifespan", "Determination of dorsal ventral asymmetry", "Detoxification", "Detoxification of copper ion", "Detoxification of nitrogen compound", "Development of primary female sexual characteristics", "Development of primary sexual characteristics", "Development of secondary female sexual characteristics", "Development of secondary sexual characteristics", "Developmental cell growth", "Developmental growth", "Developmental growth involved in morphogenesis", "Developmental induction", "Developmental maturation", "Developmental pigmentation", "Developmental process involved in reproduction", "Diadenosine polyphosphate catabolic process", "Diadenosine polyphosphate metabolic process", "Diapedesis", "Diaphragm development", "Dicarboxylic acid biosynthetic process", "Dicarboxylic acid catabolic process", "Dicarboxylic acid metabolic process", "Dicarboxylic acid transport", "Diencephalon development", "Diet induced thermogenesis", "Digestion", "Digestive system development", "Digestive system process", "Digestive tract morphogenesis", "Diol biosynthetic process", "Diol metabolic process", "Diphosphoinositol polyphosphate metabolic process", "Disaccharide metabolic process", "Diterpenoid biosynthetic process", "Divalent inorganic cation homeostasis", "Dna biosynthetic process", "Dna catabolic process", "Dna catabolic process endonucleolytic", "Dna catabolic process exonucleolytic", "Dna conformation change", "Dna damage response signal transduction by p53 class mediator", "Dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest", "Dna damage response signal transduction resulting in transcription", "Dna dealkylation", "Dna dealkylation involved in dna repair", "Dna deamination", "Dna dependent dna replication", "Dna dependent dna replication maintenance of fidelity", "Dna double strand break processing", "Dna geometric change", "Dna integration", "Dna integrity checkpoint signaling", "Dna ligation", "Dna ligation involved in dna repair", "Dna metabolic process", "Dna methylation", "Dna methylation dependent heterochromatin assembly", "Dna methylation involved in gamete generation", "Dna methylation on cytosine", "Dna methylation or demethylation", "Dna modification", "Dna packaging", "Dna protection", "Dna recombination", "Dna repair", "Dna replication", "Dna replication checkpoint signaling", "Dna replication dependent chromatin organization", "Dna replication independent chromatin organization", "Dna replication initiation", "Dna replication synthesis of rna primer", "Dna strand elongation", "Dna strand elongation involved in dna replication", "Dna synthesis involved in dna repair", "Dna templated transcription elongation", "Dna templated transcription initiation", "Dna templated transcription termination", "Dna topological change", "Dna unwinding involved in dna replication", "Dolichol metabolic process", "Dopamine biosynthetic process", "Dopamine metabolic process", "Dopamine receptor signaling pathway", "Dopamine transport", "Dopaminergic neuron differentiation", "Dorsal root ganglion development", "Dorsal ventral axis specification", "Dorsal ventral neural tube patterning", "Dorsal ventral pattern formation", "Dosage compensation", "Double strand break repair", "Double strand break repair via break induced replication", "Double strand break repair via classical nonhomologous end joining", "Double strand break repair via nonhomologous end joining", "Dsrna processing", "Dtmp metabolic process", "Dttp metabolic process", "Dump metabolic process", "Ear development", "Ear morphogenesis", "Early endosome to golgi transport", "Eating behavior", "Ectoderm development", "Ectodermal placode development", "Ectopic germ cell programmed cell death", "Egg activation", "Electron transport chain", "Embryo development", "Embryo development ending in birth or egg hatching", "Embryo implantation", "Embryonic appendage morphogenesis", "Embryonic axis specification", "Embryonic body morphogenesis", "Embryonic brain development", "Embryonic camera type eye development", "Embryonic cleavage", "Embryonic cranial skeleton morphogenesis", "Embryonic digestive tract development", "Embryonic digestive tract morphogenesis", "Embryonic digit morphogenesis", "Embryonic forelimb morphogenesis", "Embryonic heart tube development", "Embryonic hemopoiesis", "Embryonic hindlimb morphogenesis", "Embryonic morphogenesis", "Embryonic neurocranium morphogenesis", "Embryonic organ development", "Embryonic organ morphogenesis", "Embryonic pattern specification", "Embryonic placenta development", "Embryonic placenta morphogenesis", "Embryonic process involved in female pregnancy", "Embryonic skeletal joint development", "Embryonic skeletal joint morphogenesis", "Embryonic skeletal system development", "Embryonic skeletal system morphogenesis", "Embryonic viscerocranium morphogenesis", "Enamel mineralization", "Endocannabinoid signaling pathway", "Endochondral bone morphogenesis", "Endocrine pancreas development", "Endocrine process", "Endocrine system development", "Endocytic recycling", "Endocytosis", "Endoderm development", "Endoderm formation", "Endodermal cell differentiation", "Endodermal cell fate commitment", "Endomembrane system organization", "Endonucleolytic cleavage in 5 ets of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage in its1 to separate ssu rrna from 5 8s rrna and lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage involved in rrna processing", "Endoplasmic reticulum calcium ion homeostasis", "Endoplasmic reticulum localization", "Endoplasmic reticulum mannose trimming", "Endoplasmic reticulum membrane organization", "Endoplasmic reticulum organization", "Endoplasmic reticulum plasma membrane tethering", "Endoplasmic reticulum to cytosol transport", "Endoplasmic reticulum to golgi vesicle mediated transport", "Endoplasmic reticulum tubular network organization", "Endoplasmic reticulum unfolded protein response", "Endosomal lumen acidification", "Endosomal transport", "Endosome organization", "Endosome to lysosome transport", "Endosome to lysosome transport via multivesicular body sorting pathway", "Endosome to plasma membrane protein transport", "Endosome transport via multivesicular body sorting pathway", "Endothelial cell activation", "Endothelial cell apoptotic process", "Endothelial cell chemotaxis", "Endothelial cell development", "Endothelial cell matrix adhesion", "Endothelial cell migration", "Endothelial cell morphogenesis", "Endothelial cell proliferation", "Endothelin receptor signaling pathway", "Endothelium development", "Energy derivation by oxidation of organic compounds", "Energy homeostasis", "Energy reserve metabolic process", "Engulfment of apoptotic cell", "Ensheathment of neurons", "Enteroendocrine cell differentiation", "Entrainment of circadian clock", "Entry into host", "Entry of bacterium into host cell", "Enzyme directed rrna pseudouridine synthesis", "Enzyme linked receptor protein signaling pathway", "Eosinophil activation", "Eosinophil mediated immunity", "Ephrin receptor signaling pathway", "Epiboly", "Epidermal cell differentiation", "Epidermis development", "Epidermis morphogenesis", "Epigenetic maintenance of chromatin in transcription competent conformation", "Epithelial cell apoptotic process", "Epithelial cell cell adhesion", "Epithelial cell development", "Epithelial cell differentiation", "Epithelial cell differentiation involved in kidney development", "Epithelial cell differentiation involved in prostate gland development", "Epithelial cell maturation", "Epithelial cell morphogenesis", "Epithelial cell proliferation", "Epithelial cell proliferation involved in lung morphogenesis", "Epithelial cell proliferation involved in prostate gland development", "Epithelial fluid transport", "Epithelial structure maintenance", "Epithelial to mesenchymal transition", "Epithelial tube branching involved in lung morphogenesis", "Epithelial tube formation", "Epithelial tube morphogenesis", "Epithelium development", "Epoxide metabolic process", "Er associated misfolded protein catabolic process", "Er nucleus signaling pathway", "Er overload response", "Erad pathway", "Erbb signaling pathway", "Erbb2 signaling pathway", "Erk1 and erk2 cascade", "Error free translesion synthesis", "Erythrocyte development", "Erythrocyte homeostasis", "Erythrocyte maturation", "Escrt complex disassembly", "Establishment of cell polarity", "Establishment of centrosome localization", "Establishment of endothelial barrier", "Establishment of endothelial intestinal barrier", "Establishment of epithelial cell apical basal polarity", "Establishment of epithelial cell polarity", "Establishment of golgi localization", "Establishment of lymphocyte polarity", "Establishment of meiotic spindle localization", "Establishment of mitochondrion localization", "Establishment of mitotic spindle localization", "Establishment of organelle localization", "Establishment of pigment granule localization", "Establishment of planar polarity involved in neural tube closure", "Establishment of planar polarity of embryonic epithelium", "Establishment of protein localization", "Establishment of protein localization to chromatin", "Establishment of protein localization to chromosome", "Establishment of protein localization to endoplasmic reticulum", "Establishment of protein localization to membrane", "Establishment of protein localization to mitochondrial membrane", "Establishment of protein localization to organelle", "Establishment of protein localization to plasma membrane", "Establishment of protein localization to telomere", "Establishment of protein localization to vacuole", "Establishment of rna localization", "Establishment of sister chromatid cohesion", "Establishment of spindle orientation", "Establishment of tissue polarity", "Establishment or maintenance of bipolar cell polarity", "Establishment or maintenance of cell polarity", "Establishment or maintenance of cytoskeleton polarity", "Establishment or maintenance of monopolar cell polarity", "Establishment or maintenance of transmembrane electrochemical gradient", "Estrogen biosynthetic process", "Estrogen metabolic process", "Estrous cycle", "Ethanol catabolic process", "Ethanol metabolic process", "Ethanol oxidation", "Ether biosynthetic process", "Ether metabolic process", "Excitatory synapse assembly", "Excretion", "Execution phase of apoptosis", "Exit from mitosis", "Exocrine pancreas development", "Exocrine system development", "Exocyst localization", "Exocytic process", "Exocytosis", "Exonucleolytic catabolism of deadenylated mrna", "Exploration behavior", "Export across plasma membrane", "Export from cell", "External encapsulating structure organization", "Extracellular exosome assembly", "Extracellular matrix assembly", "Extracellular matrix disassembly", "Extracellular regulation of signal transduction", "Extracellular transport", "Extracellular vesicle biogenesis", "Extrinsic apoptotic signaling pathway", "Extrinsic apoptotic signaling pathway via death domain receptors", "Eye morphogenesis", "Eye photoreceptor cell development", "Eye photoreceptor cell differentiation", "Eyelid development in camera type eye", "Face development", "Facultative heterochromatin assembly", "Farnesyl diphosphate metabolic process", "Fas signaling pathway", "Fat cell differentiation", "Fat cell proliferation", "Fat soluble vitamin metabolic process", "Fatty acid alpha oxidation", "Fatty acid beta oxidation", "Fatty acid beta oxidation using acyl coa dehydrogenase", "Fatty acid beta oxidation using acyl coa oxidase", "Fatty acid biosynthetic process", "Fatty acid catabolic process", "Fatty acid derivative biosynthetic process", "Fatty acid derivative catabolic process", "Fatty acid derivative metabolic process", "Fatty acid elongation", "Fatty acid homeostasis", "Fatty acid metabolic process", "Fatty acid omega oxidation", "Fatty acid transmembrane transport", "Fatty acid transport", "Fatty acyl coa biosynthetic process", "Fatty acyl coa catabolic process", "Fatty acyl coa metabolic process", "Fc gamma receptor signaling pathway", "Fc receptor mediated stimulatory signaling pathway", "Fc receptor signaling pathway", "Fear response", "Feeding behavior", "Female gamete generation", "Female meiosis chromosome segregation", "Female meiosis i", "Female meiotic nuclear division", "Female sex differentiation", "Fermentation", "Fertilization", "Fibroblast activation", "Fibroblast apoptotic process", "Fibroblast growth factor production", "Fibroblast growth factor receptor signaling pathway", "Fibroblast migration", "Fibroblast proliferation", "Filopodium assembly", "Flavin containing compound metabolic process", "Flavonoid metabolic process", "Fluid transport", "Focal adhesion assembly", "Folate import across plasma membrane", "Folate transmembrane transport", "Folic acid containing compound biosynthetic process", "Folic acid containing compound catabolic process", "Folic acid containing compound metabolic process", "Folic acid metabolic process", "Folic acid transport", "Forebrain cell migration", "Forebrain development", "Forebrain dorsal ventral pattern formation", "Forebrain generation of neurons", "Forebrain morphogenesis", "Forebrain neuron development", "Forebrain neuron differentiation", "Forebrain radial glial cell differentiation", "Forebrain regionalization", "Foregut morphogenesis", "Forelimb morphogenesis", "Formate metabolic process", "Formation of extrachromosomal circular dna", "Formation of primary germ layer", "Formation of translation preinitiation complex", "Free ubiquitin chain polymerization", "Fructose 1 6 bisphosphate metabolic process", "Fructose 2 6 bisphosphate metabolic process", "Fructose 6 phosphate metabolic process", "Fructose metabolic process", "Fucose metabolic process", "Fungiform papilla development", "Fungiform papilla morphogenesis", "G protein coupled acetylcholine receptor signaling pathway", "G protein coupled opioid receptor signaling pathway", "G protein coupled purinergic receptor signaling pathway", "G protein coupled receptor internalization", "G protein coupled receptor signaling pathway", "G protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger", "G protein coupled receptor signaling pathway involved in heart process", "G quadruplex dna unwinding", "G0 to g1 transition", "G1 to g0 transition", "Galactose catabolic process", "Galactose metabolic process", "Gamete generation", "Gamma aminobutyric acid metabolic process", "Gamma aminobutyric acid signaling pathway", "Gamma aminobutyric acid transport", "Ganglion development", "Ganglioside catabolic process", "Ganglioside metabolic process", "Gap junction assembly", "Gap junction mediated intercellular transport", "Gas homeostasis", "Gastrulation", "Gastrulation with mouth forming second", "Gdp mannose metabolic process", "Gdp metabolic process", "Gene silencing by rna", "Generation of precursor metabolites and energy", "Genitalia development", "Genitalia morphogenesis", "Genomic imprinting", "Germ cell development", "Germ cell migration", "Germ cell proliferation", "Germinal center formation", "Gland development", "Gland morphogenesis", "Glandular epithelial cell development", "Glandular epithelial cell differentiation", "Glial cell apoptotic process", "Glial cell development", "Glial cell differentiation", "Glial cell fate commitment", "Glial cell migration", "Glial cell proliferation", "Gliogenesis", "Glomerular epithelial cell development", "Glomerular epithelial cell differentiation", "Glomerular epithelium development", "Glomerular visceral epithelial cell migration", "Glomerulus development", "Glucan biosynthetic process", "Glucocorticoid biosynthetic process", "Glucocorticoid metabolic process", "Glucosamine containing compound catabolic process", "Glucosamine containing compound metabolic process", "Glucose 6 phosphate metabolic process", "Glucose catabolic process", "Glucose import", "Glucose import in response to insulin stimulus", "Glucose metabolic process", "Glucosylceramide metabolic process", "Glutamate biosynthetic process", "Glutamate catabolic process", "Glutamate homeostasis", "Glutamate metabolic process", "Glutamate receptor signaling pathway", "Glutamate reuptake", "Glutamate secretion", "Glutamate secretion neurotransmission", "Glutamine family amino acid biosynthetic process", "Glutamine family amino acid catabolic process", "Glutamine family amino acid metabolic process", "Glutamine metabolic process", "Glutamine transport", "Glutathione metabolic process", "Glycerol 3 phosphate metabolic process", "Glycerol ether metabolic process", "Glycerolipid biosynthetic process", "Glycerolipid catabolic process", "Glycerolipid metabolic process", "Glycerophospholipid biosynthetic process", "Glycerophospholipid catabolic process", "Glycerophospholipid metabolic process", "Glycine biosynthetic process", "Glycine metabolic process", "Glycolipid biosynthetic process", "Glycolipid catabolic process", "Glycolipid transport", "Glycolytic fermentation", "Glycolytic process through fructose 6 phosphate", "Glycoprotein biosynthetic process", "Glycoprotein catabolic process", "Glycoprotein metabolic process", "Glycosaminoglycan catabolic process", "Glycoside catabolic process", "Glycoside metabolic process", "Glycosphingolipid metabolic process", "Glycosyl compound biosynthetic process", "Glycosyl compound catabolic process", "Glycosyl compound metabolic process", "Glycosylation", "Glycosylceramide catabolic process", "Glycosylceramide metabolic process", "Glyoxylate metabolic process", "Gmp biosynthetic process", "Gmp metabolic process", "Gmp salvage", "Golgi disassembly", "Golgi localization", "Golgi organization", "Golgi ribbon formation", "Golgi to endosome transport", "Golgi to lysosome transport", "Golgi to plasma membrane protein transport", "Golgi to plasma membrane transport", "Golgi to vacuole transport", "Golgi vesicle budding", "Golgi vesicle transport", "Gpi anchor metabolic process", "Granulocyte activation", "Granulocyte chemotaxis", "Granulocyte differentiation", "Granulocyte migration", "Granzyme mediated programmed cell death signaling pathway", "Grooming behavior", "Growth", "Growth hormone receptor signaling pathway via jak stat", "Growth hormone secretion", "Growth plate cartilage chondrocyte differentiation", "Growth plate cartilage development", "Gtp biosynthetic process", "Gtp metabolic process", "Guanine metabolic process", "Guanine nucleotide transmembrane transport", "Guanine nucleotide transport", "Hair cell differentiation", "Hair cycle phase", "Hair follicle maturation", "Hair follicle placode formation", "Head development", "Head morphogenesis", "Heart development", "Heart formation", "Heart growth", "Heart morphogenesis", "Heart process", "Heart valve development", "Heart valve morphogenesis", "Heat acclimation", "Hematopoietic progenitor cell differentiation", "Hematopoietic stem cell differentiation", "Hematopoietic stem cell homeostasis", "Hematopoietic stem cell proliferation", "Heme transport", "Hemidesmosome assembly", "Hemoglobin biosynthetic process", "Hemoglobin metabolic process", "Hemostasis", "Heparan sulfate proteoglycan biosynthetic process", "Heparan sulfate proteoglycan metabolic process", "Hepatic stellate cell activation", "Hepaticobiliary system development", "Hepatocyte differentiation", "Hepatocyte growth factor receptor signaling pathway", "Heterochromatin organization", "Heterotypic cell cell adhesion", "High density lipoprotein particle assembly", "High density lipoprotein particle clearance", "High density lipoprotein particle remodeling", "Hindbrain development", "Hindbrain maturation", "Hindbrain morphogenesis", "Hindbrain radial glia guided cell migration", "Hindlimb morphogenesis", "Hippo signaling", "Hippocampus development", "His purkinje system development", "Histamine production involved in inflammatory response", "Histamine secretion", "Histamine transport", "Histidine metabolic process", "Histone arginine methylation", "Histone deacetylation", "Histone deubiquitination", "Histone exchange", "Histone h2a acetylation", "Histone h2a k63 linked ubiquitination", "Histone h2a monoubiquitination", "Histone h2a phosphorylation", "Histone h2a ubiquitination", "Histone h2b ubiquitination", "Histone h3 acetylation", "Histone h3 deacetylation", "Histone h3 k14 acetylation", "Histone h3 k27 methylation", "Histone h3 k27 trimethylation", "Histone h3 k36 demethylation", "Histone h3 k36 methylation", "Histone h3 k4 demethylation", "Histone h3 k4 dimethylation", "Histone h3 k4 methylation", "Histone h3 k4 monomethylation", "Histone h3 k4 trimethylation", "Histone h3 k9 acetylation", "Histone h3 k9 demethylation", "Histone h3 k9 dimethylation", "Histone h3 k9 methylation", "Histone h3 k9 modification", "Histone h3 k9 trimethylation", "Histone h4 acetylation", "Histone h4 deacetylation", "Histone h4 k16 acetylation", "Histone h4 k20 methylation", "Histone h4 k20 trimethylation", "Histone h4 k5 acetylation", "Histone h4 r3 methylation", "Histone lysine demethylation", "Histone methylation", "Histone modification", "Histone monoubiquitination", "Histone mrna catabolic process", "Histone mrna metabolic process", "Histone phosphorylation", "Histone serine phosphorylation", "Histone threonine phosphorylation", "Histone ubiquitination", "Homeostasis of number of cells", "Homeostasis of number of cells within a tissue", "Homeostatic process", "Homocysteine metabolic process", "Homologous chromosome pairing at meiosis", "Homologous chromosome segregation", "Homologous recombination", "Homophilic cell adhesion via plasma membrane adhesion molecules", "Homotypic cell cell adhesion", "Hormone biosynthetic process", "Hormone catabolic process", "Hormone mediated signaling pathway", "Hormone metabolic process", "Hormone transport", "Humoral immune response", "Humoral immune response mediated by circulating immunoglobulin", "Hyaluronan biosynthetic process", "Hyaluronan metabolic process", "Hydrogen peroxide biosynthetic process", "Hydrogen peroxide catabolic process", "Hydrogen peroxide metabolic process", "Hydrogen sulfide biosynthetic process", "Hydrogen sulfide metabolic process", "Hyperosmotic response", "Hyperosmotic salinity response", "Hypothalamus cell differentiation", "Hypothalamus development", "Hypoxia inducible factor 1alpha signaling pathway", "I kappab kinase nf kappab signaling", "I kappab phosphorylation", "Icosanoid biosynthetic process", "Icosanoid metabolic process", "Icosanoid transport", "Immune effector process", "Immune response", "Immune response regulating cell surface receptor signaling pathway", "Immune response regulating signaling pathway", "Immune response to tumor cell", "Immune system development", "Immunoglobulin production", "Immunoglobulin production involved in immunoglobulin mediated immune response", "Immunoglobulin v d j recombination", "Immunological synapse formation", "Imp biosynthetic process", "Imp catabolic process", "Imp metabolic process", "Imp salvage", "Import across plasma membrane", "Import into cell", "Import into nucleus", "In utero embryonic development", "Inclusion body assembly", "Indolalkylamine metabolic process", "Indole containing compound biosynthetic process", "Indole containing compound metabolic process", "Inflammasome complex assembly", "Inflammatory cell apoptotic process", "Inflammatory response", "Inflammatory response to antigenic stimulus", "Inflammatory response to wounding", "Innate immune response", "Innate immune response activating signal transduction", "Innate immune response in mucosa", "Inner cell mass cell differentiation", "Inner cell mass cell proliferation", "Inner dynein arm assembly", "Inner ear auditory receptor cell differentiation", "Inner ear morphogenesis", "Inner ear receptor cell development", "Inner ear receptor cell stereocilium organization", "Inner mitochondrial membrane organization", "Innervation", "Inorganic anion transmembrane transport", "Inorganic anion transport", "Inorganic ion import across plasma membrane", "Inorganic ion transmembrane transport", "Inosine metabolic process", "Inositol lipid mediated signaling", "Inositol metabolic process", "Inositol phosphate catabolic process", "Inositol phosphate mediated signaling", "Inositol phosphate metabolic process", "Insulin like growth factor receptor signaling pathway", "Insulin metabolic process", "Insulin processing", "Insulin receptor signaling pathway", "Insulin secretion", "Insulin secretion involved in cellular response to glucose stimulus", "Integrated stress response signaling", "Integrin activation", "Integrin mediated signaling pathway", "Intercellular transport", "Interferon alpha production", "Interferon beta production", "Interferon gamma mediated signaling pathway", "Interferon gamma production", "Interleukin 1 mediated signaling pathway", "Interleukin 1 production", "Interleukin 10 production", "Interleukin 12 production", "Interleukin 13 production", "Interleukin 17 production", "Interleukin 18 production", "Interleukin 2 production", "Interleukin 23 production", "Interleukin 6 mediated signaling pathway", "Interleukin 6 production", "Interleukin 8 production", "Intermediate filament based process", "Intermediate filament bundle assembly", "Intermediate filament organization", "Intermembrane lipid transfer", "Interstrand cross link repair", "Intestinal absorption", "Intestinal epithelial cell development", "Intestinal epithelial cell differentiation", "Intestinal hexose absorption", "Intestinal lipid absorption", "Intra golgi vesicle mediated transport", "Intracellular distribution of mitochondria", "Intracellular estrogen receptor signaling pathway", "Intracellular lipid transport", "Intracellular mrna localization", "Intracellular protein transmembrane transport", "Intracellular protein transport", "Intracellular receptor signaling pathway", "Intracellular sterol transport", "Intracellular transport", "Intracellular transport of virus", "Intraciliary retrograde transport", "Intraciliary transport", "Intraciliary transport involved in cilium assembly", "Intrinsic apoptotic signaling pathway", "Intrinsic apoptotic signaling pathway by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to dna damage", "Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "Intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "Intrinsic apoptotic signaling pathway in response to hypoxia", "Intrinsic apoptotic signaling pathway in response to osmotic stress", "Intrinsic apoptotic signaling pathway in response to oxidative stress", "Ion homeostasis", "Ion transmembrane transport", "Ion transport", "Ire1 mediated unfolded protein response", "Ires dependent viral translational initiation", "Iron coordination entity transport", "Iron ion homeostasis", "Iron ion transmembrane transport", "Iron ion transport", "Iron sulfur cluster assembly", "Isocitrate metabolic process", "Isoleucine metabolic process", "Isopentenyl diphosphate biosynthetic process", "Isoprenoid biosynthetic process", "Isoprenoid metabolic process", "Isotype switching to iga isotypes", "Isotype switching to igg isotypes", "Jnk cascade", "Keratan sulfate metabolic process", "Keratinization", "Keratinocyte development", "Keratinocyte differentiation", "Keratinocyte migration", "Keratinocyte proliferation", "Ketone biosynthetic process", "Ketone body biosynthetic process", "Ketone body metabolic process", "Ketone catabolic process", "Kidney epithelium development", "Kidney mesenchyme development", "Kidney morphogenesis", "Killing by host of symbiont cells", "Killing of cells of another organism", "Kinetochore assembly", "Kinetochore organization", "Kynurenine metabolic process", "L alanine transport", "L alpha amino acid transmembrane transport", "L amino acid transport", "L ascorbic acid metabolic process", "L aspartate transmembrane transport", "L glutamate import across plasma membrane", "L glutamate transmembrane transport", "L kynurenine metabolic process", "L methionine salvage from methylthioadenosine", "L phenylalanine metabolic process", "L proline biosynthetic process", "L serine biosynthetic process", "L serine catabolic process", "L serine metabolic process", "L serine transport", "Labyrinthine layer blood vessel development", "Labyrinthine layer development", "Labyrinthine layer morphogenesis", "Lacrimal gland development", "Lactate metabolic process", "Lactate transmembrane transport", "Lactation", "Lamellipodium assembly", "Lamellipodium morphogenesis", "Lamellipodium organization", "Late endosome to golgi transport", "Late endosome to lysosome transport", "Late endosome to vacuole transport", "Late endosome to vacuole transport via multivesicular body sorting pathway", "Lateral ventricle development", "Layer formation in cerebral cortex", "Learned vocalization behavior or vocal learning", "Learning", "Lens development in camera type eye", "Lens fiber cell development", "Lens fiber cell differentiation", "Lens morphogenesis in camera type eye", "Leptin mediated signaling pathway", "Leucine catabolic process", "Leucine import across plasma membrane", "Leucine metabolic process", "Leucine transport", "Leukocyte adhesion to vascular endothelial cell", "Leukocyte aggregation", "Leukocyte apoptotic process", "Leukocyte cell cell adhesion", "Leukocyte chemotaxis", "Leukocyte degranulation", "Leukocyte differentiation", "Leukocyte homeostasis", "Leukocyte mediated cytotoxicity", "Leukocyte mediated immunity", "Leukocyte migration", "Leukocyte proliferation", "Leukocyte tethering or rolling", "Leukotriene b4 metabolic process", "Leukotriene biosynthetic process", "Leukotriene metabolic process", "Leukotriene transport", "Leydig cell differentiation", "Ligand gated ion channel signaling pathway", "Limb joint morphogenesis", "Limbic system development", "Linoleic acid metabolic process", "Lipid biosynthetic process", "Lipid catabolic process", "Lipid digestion", "Lipid droplet formation", "Lipid droplet organization", "Lipid export from cell", "Lipid glycosylation", "Lipid homeostasis", "Lipid import into cell", "Lipid localization", "Lipid metabolic process", "Lipid modification", "Lipid oxidation", "Lipid phosphorylation", "Lipid storage", "Lipid translocation", "Lipid transport across blood brain barrier", "Lipophagy", "Lipopolysaccharide mediated signaling pathway", "Lipoprotein biosynthetic process", "Lipoprotein catabolic process", "Lipoprotein localization", "Lipoprotein metabolic process", "Liposaccharide metabolic process", "Lipoxin metabolic process", "Liver morphogenesis", "Liver regeneration", "Localization within membrane", "Locomotion", "Locomotion involved in locomotory behavior", "Locomotor rhythm", "Locomotory behavior", "Locomotory exploration behavior", "Long chain fatty acid biosynthetic process", "Long chain fatty acid import across plasma membrane", "Long chain fatty acid metabolic process", "Long chain fatty acid transport", "Long chain fatty acyl coa biosynthetic process", "Long chain fatty acyl coa metabolic process", "Long term memory", "Long term synaptic depression", "Long term synaptic potentiation", "Low density lipoprotein particle clearance", "Low density lipoprotein receptor particle metabolic process", "Lung alveolus development", "Lung associated mesenchyme development", "Lung cell differentiation", "Lung epithelium development", "Lung lobe development", "Lung morphogenesis", "Lung saccule development", "Lung secretory cell differentiation", "Luteinization", "Luteolysis", "Lymph vessel development", "Lymph vessel morphogenesis", "Lymphangiogenesis", "Lymphocyte activation", "Lymphocyte activation involved in immune response", "Lymphocyte aggregation", "Lymphocyte anergy", "Lymphocyte apoptotic process", "Lymphocyte chemotaxis", "Lymphocyte costimulation", "Lymphocyte homeostasis", "Lymphocyte mediated immunity", "Lymphocyte migration", "Lymphoid progenitor cell differentiation", "Lysine catabolic process", "Lysine metabolic process", "Lysosomal lumen acidification", "Lysosomal membrane organization", "Lysosomal microautophagy", "Lysosomal protein catabolic process", "Lysosomal transport", "Lytic vacuole organization", "Macroautophagy", "Macromolecule catabolic process", "Macromolecule deacylation", "Macromolecule depalmitoylation", "Macrophage activation", "Macrophage apoptotic process", "Macrophage chemotaxis", "Macrophage differentiation", "Macrophage inflammatory protein 1 alpha production", "Macrophage migration", "Macrophage proliferation", "Macropinocytosis", "Magnesium ion homeostasis", "Magnesium ion transport", "Maintenance of apical basal cell polarity", "Maintenance of blood brain barrier", "Maintenance of cell number", "Maintenance of cell polarity", "Maintenance of centrosome location", "Maintenance of dna methylation", "Maintenance of dna repeat elements", "Maintenance of gastrointestinal epithelium", "Maintenance of lens transparency", "Maintenance of location", "Maintenance of location in cell", "Maintenance of organelle location", "Maintenance of postsynaptic specialization structure", "Maintenance of presynaptic active zone structure", "Maintenance of protein localization in endoplasmic reticulum", "Maintenance of protein localization in organelle", "Maintenance of protein location", "Maintenance of protein location in cell", "Maintenance of protein location in mitochondrion", "Maintenance of protein location in nucleus", "Maintenance of sister chromatid cohesion", "Maintenance of synapse structure", "Malate metabolic process", "Male gamete generation", "Male genitalia development", "Male mating behavior", "Male meiosis i", "Male meiotic nuclear division", "Male sex determination", "Male sex differentiation", "Malonyl coa metabolic process", "Mammalian oogenesis stage", "Mammary gland alveolus development", "Mammary gland development", "Mammary gland duct morphogenesis", "Mammary gland epithelial cell differentiation", "Mammary gland epithelial cell proliferation", "Mammary gland epithelium development", "Mammary gland involution", "Mammary gland morphogenesis", "Manganese ion transmembrane transport", "Manganese ion transport", "Mannose metabolic process", "Mannosylation", "Mapk cascade", "Mast cell activation", "Mast cell activation involved in immune response", "Mast cell cytokine production", "Maternal placenta development", "Maternal process involved in female pregnancy", "Mating", "Mating behavior", "Maturation of 5 8s rrna", "Maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of lsu rrna", "Maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of ssu rrna", "Maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Mature ribosome assembly", "Mda 5 signaling pathway", "Mechanoreceptor differentiation", "Mechanosensory behavior", "Medium chain fatty acid biosynthetic process", "Medium chain fatty acid catabolic process", "Medium chain fatty acid metabolic process", "Medium chain fatty acyl coa metabolic process", "Megakaryocyte differentiation", "Meiosis i cell cycle process", "Meiosis ii cell cycle process", "Meiotic cell cycle", "Meiotic cell cycle checkpoint signaling", "Meiotic cell cycle phase transition", "Meiotic cell cycle process", "Meiotic chromosome condensation", "Meiotic chromosome segregation", "Meiotic chromosome separation", "Meiotic cytokinesis", "Meiotic dna double strand break formation", "Meiotic sister chromatid cohesion centromeric", "Meiotic spindle organization", "Melanocyte differentiation", "Membrane biogenesis", "Membrane depolarization", "Membrane depolarization during action potential", "Membrane depolarization during cardiac muscle cell action potential", "Membrane disassembly", "Membrane docking", "Membrane fission", "Membrane fusion", "Membrane fusion involved in viral entry into host cell", "Membrane hyperpolarization", "Membrane invagination", "Membrane lipid biosynthetic process", "Membrane lipid catabolic process", "Membrane lipid metabolic process", "Membrane organization", "Membrane protein ectodomain proteolysis", "Membrane protein intracellular domain proteolysis", "Membrane protein proteolysis", "Membrane raft assembly", "Membrane raft localization", "Membrane raft organization", "Membrane repolarization", "Membrane repolarization during action potential", "Membrane repolarization during atrial cardiac muscle cell action potential", "Membrane repolarization during cardiac muscle cell action potential", "Membrane to membrane docking", "Membranous septum morphogenesis", "Memory", "Mesenchymal cell development", "Mesenchymal cell differentiation", "Mesenchymal cell proliferation", "Mesenchymal cell proliferation involved in lung development", "Mesenchymal stem cell differentiation", "Mesenchymal stem cell proliferation", "Mesenchymal to epithelial transition", "Mesenchymal to epithelial transition involved in metanephros morphogenesis", "Mesenchyme development", "Mesenchyme morphogenesis", "Mesoderm development", "Mesoderm morphogenesis", "Mesodermal cell differentiation", "Mesonephric tubule morphogenesis", "Mesonephros development", "Metal ion export", "Metal ion homeostasis", "Metal ion transport", "Metanephric collecting duct development", "Metanephric epithelium development", "Metanephric mesenchyme development", "Metanephric nephron development", "Metanephric nephron morphogenesis", "Metanephric part of ureteric bud development", "Metanephric renal vesicle morphogenesis", "Metanephric tubule development", "Metanephros development", "Metanephros morphogenesis", "Metaphase anaphase transition of cell cycle", "Metaphase plate congression", "Metencephalon development", "Methionine biosynthetic process", "Methionine metabolic process", "Methylation", "Methylglyoxal metabolic process", "Methylguanosine cap decapping", "Mhc class i biosynthetic process", "Mhc class ii biosynthetic process", "Microglia differentiation", "Microglial cell activation", "Microglial cell proliferation", "Microtubule anchoring", "Microtubule anchoring at centrosome", "Microtubule anchoring at microtubule organizing center", "Microtubule based movement", "Microtubule based process", "Microtubule based transport", "Microtubule bundle formation", "Microtubule cytoskeleton organization", "Microtubule cytoskeleton organization involved in mitosis", "Microtubule depolymerization", "Microtubule nucleation", "Microtubule organizing center localization", "Microtubule organizing center organization", "Microtubule polymerization", "Microtubule polymerization or depolymerization", "Microvillus assembly", "Microvillus organization", "Midbody abscission", "Midbrain development", "Midbrain dopaminergic neuron differentiation", "Middle ear morphogenesis", "Midgut development", "Minus end directed organelle transport along microtubule", "Mirna catabolic process", "Mirna loading onto risc involved in gene silencing by mirna", "Mirna metabolic process", "Mismatch repair", "Mitochondrial acetyl coa biosynthetic process from pyruvate", "Mitochondrial adp transmembrane transport", "Mitochondrial atp synthesis coupled proton transport", "Mitochondrial calcium ion homeostasis", "Mitochondrial calcium ion transmembrane transport", "Mitochondrial cytochrome c oxidase assembly", "Mitochondrial depolarization", "Mitochondrial dna metabolic process", "Mitochondrial dna repair", "Mitochondrial dna replication", "Mitochondrial electron transport cytochrome c to oxygen", "Mitochondrial electron transport nadh to ubiquinone", "Mitochondrial electron transport ubiquinol to cytochrome c", "Mitochondrial fission", "Mitochondrial fragmentation involved in apoptotic process", "Mitochondrial fusion", "Mitochondrial gene expression", "Mitochondrial genome maintenance", "Mitochondrial membrane organization", "Mitochondrial outer membrane permeabilization", "Mitochondrial outer membrane permeabilization involved in programmed cell death", "Mitochondrial protein catabolic process", "Mitochondrial protein processing", "Mitochondrial respirasome assembly", "Mitochondrial respiratory chain complex assembly", "Mitochondrial ribosome assembly", "Mitochondrial rna 3 end processing", "Mitochondrial rna catabolic process", "Mitochondrial rna metabolic process", "Mitochondrial rna modification", "Mitochondrial rna processing", "Mitochondrial transcription", "Mitochondrial translation", "Mitochondrial translational elongation", "Mitochondrial transmembrane transport", "Mitochondrial transport", "Mitochondrial trna processing", "Mitochondrion distribution", "Mitochondrion endoplasmic reticulum membrane tethering", "Mitochondrion localization", "Mitochondrion morphogenesis", "Mitochondrion organization", "Mitophagy", "Mitotic cell cycle", "Mitotic cell cycle checkpoint signaling", "Mitotic cell cycle phase transition", "Mitotic cell cycle process", "Mitotic chromosome condensation", "Mitotic cytokinesis", "Mitotic cytokinetic process", "Mitotic dna integrity checkpoint signaling", "Mitotic dna replication", "Mitotic dna replication checkpoint signaling", "Mitotic g1 s transition checkpoint signaling", "Mitotic g2 dna damage checkpoint signaling", "Mitotic g2 m transition checkpoint", "Mitotic intra s dna damage checkpoint signaling", "Mitotic metaphase plate congression", "Mitotic nuclear division", "Mitotic nuclear membrane disassembly", "Mitotic nuclear membrane organization", "Mitotic recombination", "Mitotic sister chromatid cohesion", "Mitotic sister chromatid segregation", "Mitotic spindle assembly", "Mitotic spindle midzone assembly", "Mitotic spindle organization", "Modification dependent macromolecule catabolic process", "Modification of postsynaptic actin cytoskeleton", "Modification of postsynaptic structure", "Modification of synaptic structure", "Modified amino acid transport", "Modulation by host of symbiont catalytic activity", "Modulation by host of symbiont process", "Modulation by host of viral genome replication", "Modulation by host of viral process", "Modulation of age related behavioral decline", "Modulation of excitatory postsynaptic potential", "Molting cycle", "Monoacylglycerol catabolic process", "Monoacylglycerol metabolic process", "Monoamine transport", "Monocarboxylic acid biosynthetic process", "Monocarboxylic acid catabolic process", "Monocarboxylic acid metabolic process", "Monocarboxylic acid transport", "Monocyte chemotaxis", "Monocyte differentiation", "Mononuclear cell differentiation", "Mononuclear cell migration", "Monosaccharide biosynthetic process", "Monosaccharide catabolic process", "Monosaccharide metabolic process", "Monoubiquitinated protein deubiquitination", "Monovalent inorganic anion homeostasis", "Monovalent inorganic cation homeostasis", "Morphogenesis of a branching structure", "Morphogenesis of a polarized epithelium", "Morphogenesis of an endothelium", "Morphogenesis of an epithelial bud", "Morphogenesis of an epithelial fold", "Morphogenesis of an epithelial sheet", "Morphogenesis of an epithelium", "Morphogenesis of embryonic epithelium", "Motor behavior", "Motor learning", "Motor neuron apoptotic process", "Motor neuron axon guidance", "Mrna 3 end processing", "Mrna 3 end processing by stem loop binding and cleavage", "Mrna 3 splice site recognition", "Mrna 5 splice site recognition", "Mrna alternative polyadenylation", "Mrna catabolic process", "Mrna cis splicing via spliceosome", "Mrna cleavage", "Mrna cleavage involved in mrna processing", "Mrna destabilization mediated gene silencing", "Mrna export from nucleus", "Mrna metabolic process", "Mrna methylation", "Mrna modification", "Mrna processing", "Mrna pseudouridine synthesis", "Mrna splice site selection", "Mrna transcription", "Mrna transport", "Mucopolysaccharide metabolic process", "Multi multicellular organism process", "Multi organism reproductive process", "Multicellular organism aging", "Multicellular organism growth", "Multicellular organism reproduction", "Multicellular organismal homeostasis", "Multicellular organismal movement", "Multicellular organismal response to stress", "Multicellular organismal signaling", "Multivesicular body organization", "Multivesicular body sorting pathway", "Muscle adaptation", "Muscle cell apoptotic process", "Muscle cell cellular homeostasis", "Muscle cell development", "Muscle cell differentiation", "Muscle cell migration", "Muscle cell proliferation", "Muscle contraction", "Muscle hypertrophy", "Muscle hypertrophy in response to stress", "Muscle organ development", "Muscle organ morphogenesis", "Muscle structure development", "Muscle system process", "Muscle tissue development", "Myd88 dependent toll like receptor signaling pathway", "Myelin assembly", "Myelin maintenance", "Myeloid cell activation involved in immune response", "Myeloid cell apoptotic process", "Myeloid cell development", "Myeloid cell differentiation", "Myeloid cell homeostasis", "Myeloid dendritic cell activation", "Myeloid dendritic cell cytokine production", "Myeloid leukocyte activation", "Myeloid leukocyte cytokine production", "Myeloid leukocyte differentiation", "Myeloid leukocyte mediated immunity", "Myeloid leukocyte migration", "Myeloid progenitor cell differentiation", "Myoblast differentiation", "Myoblast fusion", "Myoblast migration", "Myofibroblast differentiation", "Myotube cell development", "Myotube differentiation", "N acetylglucosamine metabolic process", "N acetylneuraminate catabolic process", "N acetylneuraminate metabolic process", "N glycan processing", "N terminal peptidyl methionine acetylation", "N terminal protein amino acid acetylation", "N terminal protein amino acid modification", "N terminal protein lipidation", "Nad biosynthesis via nicotinamide riboside salvage pathway", "Nad metabolic process", "Nadh dehydrogenase complex assembly", "Nadh metabolic process", "Nadh oxidation", "Nadh regeneration", "Nadp metabolic process", "Nadph regeneration", "Natural killer cell activation", "Natural killer cell activation involved in immune response", "Natural killer cell degranulation", "Natural killer cell differentiation", "Natural killer cell mediated immune response to tumor cell", "Natural killer cell mediated immunity", "Ncrna 3 end processing", "Ncrna catabolic process", "Ncrna export from nucleus", "Ncrna metabolic process", "Ncrna processing", "Ncrna transcription", "Necroptotic signaling pathway", "Necrotic cell death", "Negative chemotaxis", "Negative regulation by host of viral genome replication", "Negative regulation by host of viral process", "Negative regulation by host of viral transcription", "Negative regulation of actin filament bundle assembly", "Negative regulation of actin filament depolymerization", "Negative regulation of actin filament polymerization", "Negative regulation of actin nucleation", "Negative regulation of activated t cell proliferation", "Negative regulation of activin receptor signaling pathway", "Negative regulation of adaptive immune response", "Negative regulation of adenylate cyclase activating adrenergic receptor signaling pathway", "Negative regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Negative regulation of adenylate cyclase activity", "Negative regulation of alcohol biosynthetic process", "Negative regulation of alpha beta t cell activation", "Negative regulation of alpha beta t cell differentiation", "Negative regulation of alpha beta t cell proliferation", "Negative regulation of amine transport", "Negative regulation of amino acid transport", "Negative regulation of amyloid beta clearance", "Negative regulation of amyloid fibril formation", "Negative regulation of amyloid precursor protein biosynthetic process", "Negative regulation of amyloid precursor protein catabolic process", "Negative regulation of androgen receptor signaling pathway", "Negative regulation of anion transmembrane transport", "Negative regulation of anion transport", "Negative regulation of anoikis", "Negative regulation of antigen receptor mediated signaling pathway", "Negative regulation of apoptotic process involved in development", "Negative regulation of apoptotic signaling pathway", "Negative regulation of arp2 3 complex mediated actin nucleation", "Negative regulation of atp biosynthetic process", "Negative regulation of atp dependent activity", "Negative regulation of atp metabolic process", "Negative regulation of autophagosome assembly", "Negative regulation of autophagosome maturation", "Negative regulation of autophagy", "Negative regulation of autophagy of mitochondrion", "Negative regulation of axon extension", "Negative regulation of axonogenesis", "Negative regulation of b cell activation", "Negative regulation of b cell apoptotic process", "Negative regulation of b cell differentiation", "Negative regulation of b cell mediated immunity", "Negative regulation of behavior", "Negative regulation of bicellular tight junction assembly", "Negative regulation of binding", "Negative regulation of biomineralization", "Negative regulation of biosynthetic process", "Negative regulation of blood circulation", "Negative regulation of blood pressure", "Negative regulation of blood vessel endothelial cell migration", "Negative regulation of bmp signaling pathway", "Negative regulation of bone remodeling", "Negative regulation of calcineurin mediated signaling", "Negative regulation of calcium ion dependent exocytosis", "Negative regulation of calcium ion import", "Negative regulation of calcium ion transmembrane transport", "Negative regulation of calcium ion transport", "Negative regulation of calcium ion transport into cytosol", "Negative regulation of calcium mediated signaling", "Negative regulation of camp dependent protein kinase activity", "Negative regulation of camp mediated signaling", "Negative regulation of canonical wnt signaling pathway", "Negative regulation of carbohydrate metabolic process", "Negative regulation of cardiac muscle adaptation", "Negative regulation of cardiac muscle contraction", "Negative regulation of cardiac muscle tissue growth", "Negative regulation of cartilage development", "Negative regulation of catabolic process", "Negative regulation of catalytic activity", "Negative regulation of cation channel activity", "Negative regulation of cd4 positive alpha beta t cell activation", "Negative regulation of cd4 positive alpha beta t cell differentiation", "Negative regulation of cd4 positive alpha beta t cell proliferation", "Negative regulation of cell activation", "Negative regulation of cell adhesion", "Negative regulation of cell aging", "Negative regulation of cell cell adhesion", "Negative regulation of cell cycle", "Negative regulation of cell cycle checkpoint", "Negative regulation of cell cycle g1 s phase transition", "Negative regulation of cell cycle g2 m phase transition", "Negative regulation of cell cycle phase transition", "Negative regulation of cell cycle process", "Negative regulation of cell death", "Negative regulation of cell development", "Negative regulation of cell differentiation", "Negative regulation of cell division", "Negative regulation of cell growth", "Negative regulation of cell growth involved in cardiac muscle cell development", "Negative regulation of cell junction assembly", "Negative regulation of cell killing", "Negative regulation of cell matrix adhesion", "Negative regulation of cell migration involved in sprouting angiogenesis", "Negative regulation of cell morphogenesis involved in differentiation", "Negative regulation of cell population proliferation", "Negative regulation of cell projection organization", "Negative regulation of cell size", "Negative regulation of cell substrate adhesion", "Negative regulation of cell substrate junction organization", "Negative regulation of cell volume", "Negative regulation of cellular amide metabolic process", "Negative regulation of cellular amine metabolic process", "Negative regulation of cellular catabolic process", "Negative regulation of cellular component organization", "Negative regulation of cellular macromolecule biosynthetic process", "Negative regulation of cellular protein catabolic process", "Negative regulation of cellular respiration", "Negative regulation of cellular response to growth factor stimulus", "Negative regulation of cellular response to hypoxia", "Negative regulation of cellular response to insulin stimulus", "Negative regulation of cellular response to vascular endothelial growth factor stimulus", "Negative regulation of cellular senescence", "Negative regulation of centriole replication", "Negative regulation of centrosome duplication", "Negative regulation of chemokine c c motif ligand 5 production", "Negative regulation of chemokine mediated signaling pathway", "Negative regulation of chemokine production", "Negative regulation of chemotaxis", "Negative regulation of cholesterol metabolic process", "Negative regulation of chondrocyte differentiation", "Negative regulation of chromatin binding", "Negative regulation of chromosome organization", "Negative regulation of cilium assembly", "Negative regulation of circadian rhythm", "Negative regulation of cold induced thermogenesis", "Negative regulation of collateral sprouting", "Negative regulation of cyclic nucleotide phosphodiesterase activity", "Negative regulation of cyclin dependent protein serine threonine kinase activity", "Negative regulation of cysteine type endopeptidase activity", "Negative regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Negative regulation of cytokine production", "Negative regulation of cytokine production involved in immune response", "Negative regulation of cytokine production involved in inflammatory response", "Negative regulation of cytoplasmic translation", "Negative regulation of cytoskeleton organization", "Negative regulation of cytosolic calcium ion concentration", "Negative regulation of defense response", "Negative regulation of defense response to bacterium", "Negative regulation of defense response to virus", "Negative regulation of delayed rectifier potassium channel activity", "Negative regulation of dendrite development", "Negative regulation of dendrite morphogenesis", "Negative regulation of dendritic spine development", "Negative regulation of dephosphorylation", "Negative regulation of developmental growth", "Negative regulation of developmental process", "Negative regulation of dna binding", "Negative regulation of dna binding transcription factor activity", "Negative regulation of dna biosynthetic process", "Negative regulation of dna damage checkpoint", "Negative regulation of dna damage response signal transduction by p53 class mediator", "Negative regulation of dna dependent dna replication", "Negative regulation of dna metabolic process", "Negative regulation of dna recombination", "Negative regulation of dna repair", "Negative regulation of dna replication", "Negative regulation of dna templated transcription elongation", "Negative regulation of dna templated transcription initiation", "Negative regulation of double strand break repair via homologous recombination", "Negative regulation of double strand break repair via nonhomologous end joining", "Negative regulation of endocytosis", "Negative regulation of endoplasmic reticulum calcium ion concentration", "Negative regulation of endoplasmic reticulum stress induced eif2 alpha phosphorylation", "Negative regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Negative regulation of endoplasmic reticulum unfolded protein response", "Negative regulation of endothelial cell apoptotic process", "Negative regulation of endothelial cell proliferation", "Negative regulation of epidermal growth factor activated receptor activity", "Negative regulation of epithelial cell apoptotic process", "Negative regulation of epithelial cell differentiation", "Negative regulation of epithelial cell migration", "Negative regulation of epithelial cell proliferation", "Negative regulation of erad pathway", "Negative regulation of erbb signaling pathway", "Negative regulation of erk1 and erk2 cascade", "Negative regulation of erythrocyte differentiation", "Negative regulation of establishment of protein localization", "Negative regulation of establishment of protein localization to mitochondrion", "Negative regulation of excitatory postsynaptic potential", "Negative regulation of execution phase of apoptosis", "Negative regulation of exocytosis", "Negative regulation of extrinsic apoptotic signaling pathway", "Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Negative regulation of fat cell differentiation", "Negative regulation of fatty acid beta oxidation", "Negative regulation of fatty acid biosynthetic process", "Negative regulation of fatty acid metabolic process", "Negative regulation of fatty acid oxidation", "Negative regulation of fatty acid transport", "Negative regulation of feeding behavior", "Negative regulation of fibroblast apoptotic process", "Negative regulation of fibroblast migration", "Negative regulation of fibroblast proliferation", "Negative regulation of filopodium assembly", "Negative regulation of g protein coupled receptor signaling pathway", "Negative regulation of gene expression", "Negative regulation of gene expression epigenetic", "Negative regulation of glial cell differentiation", "Negative regulation of glial cell proliferation", "Negative regulation of gliogenesis", "Negative regulation of glucocorticoid metabolic process", "Negative regulation of gluconeogenesis", "Negative regulation of glucose import", "Negative regulation of glucose transmembrane transport", "Negative regulation of glycogen metabolic process", "Negative regulation of glycolytic process", "Negative regulation of glycoprotein metabolic process", "Negative regulation of golgi to plasma membrane protein transport", "Negative regulation of granulocyte chemotaxis", "Negative regulation of granulocyte differentiation", "Negative regulation of growth", "Negative regulation of gtpase activity", "Negative regulation of guanyl nucleotide exchange factor activity", "Negative regulation of heart rate", "Negative regulation of helicase activity", "Negative regulation of hematopoietic progenitor cell differentiation", "Negative regulation of hemopoiesis", "Negative regulation of histone acetylation", "Negative regulation of histone h3 k27 methylation", "Negative regulation of histone h3 k4 methylation", "Negative regulation of histone h3 k9 methylation", "Negative regulation of histone h3 k9 trimethylation", "Negative regulation of histone h4 acetylation", "Negative regulation of histone methylation", "Negative regulation of histone modification", "Negative regulation of histone phosphorylation", "Negative regulation of homotypic cell cell adhesion", "Negative regulation of hormone biosynthetic process", "Negative regulation of hormone metabolic process", "Negative regulation of hormone secretion", "Negative regulation of hydrogen peroxide mediated programmed cell death", "Negative regulation of hydrolase activity", "Negative regulation of hypoxia induced intrinsic apoptotic signaling pathway", "Negative regulation of i kappab kinase nf kappab signaling", "Negative regulation of immune effector process", "Negative regulation of immune response", "Negative regulation of immune system process", "Negative regulation of immunoglobulin production", "Negative regulation of inclusion body assembly", "Negative regulation of inflammatory response", "Negative regulation of inflammatory response to antigenic stimulus", "Negative regulation of innate immune response", "Negative regulation of insulin secretion involved in cellular response to glucose stimulus", "Negative regulation of interferon gamma production", "Negative regulation of interleukin 12 production", "Negative regulation of interleukin 13 production", "Negative regulation of interleukin 17 production", "Negative regulation of interleukin 2 production", "Negative regulation of interleukin 6 production", "Negative regulation of interleukin 8 production", "Negative regulation of intracellular estrogen receptor signaling pathway", "Negative regulation of intracellular protein transport", "Negative regulation of intracellular signal transduction", "Negative regulation of intracellular steroid hormone receptor signaling pathway", "Negative regulation of intracellular transport", "Negative regulation of intrinsic apoptotic signaling pathway", "Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Negative regulation of ion transmembrane transport", "Negative regulation of ion transmembrane transporter activity", "Negative regulation of ion transport", "Negative regulation of ire1 mediated unfolded protein response", "Negative regulation of isotype switching", "Negative regulation of jnk cascade", "Negative regulation of jun kinase activity", "Negative regulation of keratinocyte proliferation", "Negative regulation of kinase activity", "Negative regulation of lamellipodium assembly", "Negative regulation of lamellipodium organization", "Negative regulation of leukocyte apoptotic process", "Negative regulation of leukocyte cell cell adhesion", "Negative regulation of leukocyte chemotaxis", "Negative regulation of leukocyte degranulation", "Negative regulation of leukocyte mediated immunity", "Negative regulation of leukocyte migration", "Negative regulation of leukocyte proliferation", "Negative regulation of lipase activity", "Negative regulation of lipid biosynthetic process", "Negative regulation of lipid catabolic process", "Negative regulation of lipid localization", "Negative regulation of lipid metabolic process", "Negative regulation of lipid transport", "Negative regulation of lipopolysaccharide mediated signaling pathway", "Negative regulation of lipoprotein lipase activity", "Negative regulation of lipoprotein particle clearance", "Negative regulation of locomotion", "Negative regulation of long term synaptic potentiation", "Negative regulation of low density lipoprotein particle clearance", "Negative regulation of low density lipoprotein receptor activity", "Negative regulation of lyase activity", "Negative regulation of lymphocyte activation", "Negative regulation of lymphocyte apoptotic process", "Negative regulation of lymphocyte differentiation", "Negative regulation of lymphocyte mediated immunity", "Negative regulation of lymphocyte migration", "Negative regulation of macroautophagy", "Negative regulation of macrophage chemotaxis", "Negative regulation of macrophage migration", "Negative regulation of map kinase activity", "Negative regulation of mapk cascade", "Negative regulation of mast cell activation", "Negative regulation of mast cell activation involved in immune response", "Negative regulation of mast cell degranulation", "Negative regulation of megakaryocyte differentiation", "Negative regulation of meiotic cell cycle", "Negative regulation of meiotic nuclear division", "Negative regulation of membrane permeability", "Negative regulation of membrane potential", "Negative regulation of mesenchymal cell proliferation", "Negative regulation of metalloendopeptidase activity", "Negative regulation of metallopeptidase activity", "Negative regulation of metaphase anaphase transition of cell cycle", "Negative regulation of mhc class ii biosynthetic process", "Negative regulation of microtubule polymerization", "Negative regulation of microtubule polymerization or depolymerization", "Negative regulation of mitochondrial fusion", "Negative regulation of mitochondrial membrane permeability", "Negative regulation of mitochondrial membrane permeability involved in apoptotic process", "Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Negative regulation of mitochondrion organization", "Negative regulation of mitophagy", "Negative regulation of mitotic cell cycle", "Negative regulation of mitotic cell cycle phase transition", "Negative regulation of molecular function", "Negative regulation of monocyte chemotaxis", "Negative regulation of monocyte differentiation", "Negative regulation of mononuclear cell migration", "Negative regulation of monooxygenase activity", "Negative regulation of mrna 3 end processing", "Negative regulation of mrna catabolic process", "Negative regulation of mrna metabolic process", "Negative regulation of mrna processing", "Negative regulation of mrna splicing via spliceosome", "Negative regulation of multicellular organism growth", "Negative regulation of multicellular organismal process", "Negative regulation of muscle adaptation", "Negative regulation of muscle cell apoptotic process", "Negative regulation of muscle cell differentiation", "Negative regulation of muscle contraction", "Negative regulation of muscle hypertrophy", "Negative regulation of muscle organ development", "Negative regulation of muscle tissue development", "Negative regulation of myeloid cell apoptotic process", "Negative regulation of myeloid cell differentiation", "Negative regulation of myeloid leukocyte differentiation", "Negative regulation of myeloid leukocyte mediated immunity", "Negative regulation of myoblast differentiation", "Negative regulation of myosin light chain phosphatase activity", "Negative regulation of myotube differentiation", "Negative regulation of natural killer cell mediated immunity", "Negative regulation of necrotic cell death", "Negative regulation of nervous system development", "Negative regulation of neural precursor cell proliferation", "Negative regulation of neuroblast proliferation", "Negative regulation of neuron apoptotic process", "Negative regulation of neuron death", "Negative regulation of neuron differentiation", "Negative regulation of neuron migration", "Negative regulation of neuron projection development", "Negative regulation of neuron projection regeneration", "Negative regulation of neurotransmitter secretion", "Negative regulation of neurotransmitter transport", "Negative regulation of neutrophil migration", "Negative regulation of nf kappab transcription factor activity", "Negative regulation of nik nf kappab signaling", "Negative regulation of nitric oxide metabolic process", "Negative regulation of nitric oxide synthase activity", "Negative regulation of nlrp3 inflammasome complex assembly", "Negative regulation of notch signaling pathway", "Negative regulation of nuclear division", "Negative regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Negative regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Negative regulation of nuclease activity", "Negative regulation of nucleobase containing compound metabolic process", "Negative regulation of nucleocytoplasmic transport", "Negative regulation of nucleotide biosynthetic process", "Negative regulation of nucleotide metabolic process", "Negative regulation of oligodendrocyte differentiation", "Negative regulation of organ growth", "Negative regulation of organelle assembly", "Negative regulation of organelle organization", "Negative regulation of organic acid transport", "Negative regulation of osteoblast differentiation", "Negative regulation of osteoblast proliferation", "Negative regulation of osteoclast differentiation", "Negative regulation of oxidative phosphorylation", "Negative regulation of oxidative stress induced cell death", "Negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Negative regulation of oxidative stress induced neuron death", "Negative regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway", "Negative regulation of oxidoreductase activity", "Negative regulation of p38mapk cascade", "Negative regulation of peptidase activity", "Negative regulation of peptide secretion", "Negative regulation of peptidyl cysteine s nitrosylation", "Negative regulation of peptidyl lysine acetylation", "Negative regulation of peptidyl serine phosphorylation", "Negative regulation of peptidyl threonine phosphorylation", "Negative regulation of peptidyl tyrosine phosphorylation", "Negative regulation of perk mediated unfolded protein response", "Negative regulation of phagocytosis", "Negative regulation of phosphatase activity", "Negative regulation of phosphatidylinositol 3 kinase signaling", "Negative regulation of phospholipase activity", "Negative regulation of phospholipid metabolic process", "Negative regulation of phosphoprotein phosphatase activity", "Negative regulation of phosphorus metabolic process", "Negative regulation of phosphorylation", "Negative regulation of plasma membrane bounded cell projection assembly", "Negative regulation of platelet derived growth factor receptor signaling pathway", "Negative regulation of posttranscriptional gene silencing", "Negative regulation of potassium ion transmembrane transport", "Negative regulation of potassium ion transport", "Negative regulation of production of mirnas involved in gene silencing by mirna", "Negative regulation of production of molecular mediator of immune response", "Negative regulation of programmed necrotic cell death", "Negative regulation of proteasomal protein catabolic process", "Negative regulation of proteasomal ubiquitin dependent protein catabolic process", "Negative regulation of protein acetylation", "Negative regulation of protein autophosphorylation", "Negative regulation of protein binding", "Negative regulation of protein catabolic process", "Negative regulation of protein containing complex assembly", "Negative regulation of protein containing complex disassembly", "Negative regulation of protein dephosphorylation", "Negative regulation of protein export from nucleus", "Negative regulation of protein import into nucleus", "Negative regulation of protein k63 linked ubiquitination", "Negative regulation of protein kinase activity by regulation of protein phosphorylation", "Negative regulation of protein kinase b signaling", "Negative regulation of protein localization", "Negative regulation of protein localization to cell periphery", "Negative regulation of protein localization to cell surface", "Negative regulation of protein localization to membrane", "Negative regulation of protein localization to nucleus", "Negative regulation of protein maturation", "Negative regulation of protein metabolic process", "Negative regulation of protein modification by small protein conjugation or removal", "Negative regulation of protein modification process", "Negative regulation of protein polymerization", "Negative regulation of protein polyubiquitination", "Negative regulation of protein secretion", "Negative regulation of protein serine threonine kinase activity", "Negative regulation of protein sumoylation", "Negative regulation of protein targeting to membrane", "Negative regulation of protein targeting to mitochondrion", "Negative regulation of protein tyrosine kinase activity", "Negative regulation of proteolysis", "Negative regulation of proteolysis involved in cellular protein catabolic process", "Negative regulation of reactive oxygen species biosynthetic process", "Negative regulation of reactive oxygen species metabolic process", "Negative regulation of receptor binding", "Negative regulation of receptor internalization", "Negative regulation of receptor mediated endocytosis", "Negative regulation of receptor signaling pathway via jak stat", "Negative regulation of receptor signaling pathway via stat", "Negative regulation of regulated secretory pathway", "Negative regulation of release of cytochrome c from mitochondria", "Negative regulation of reproductive process", "Negative regulation of respiratory burst", "Negative regulation of respiratory burst involved in inflammatory response", "Negative regulation of response to biotic stimulus", "Negative regulation of response to cytokine stimulus", "Negative regulation of response to dna damage stimulus", "Negative regulation of response to endoplasmic reticulum stress", "Negative regulation of response to external stimulus", "Negative regulation of response to food", "Negative regulation of response to oxidative stress", "Negative regulation of response to reactive oxygen species", "Negative regulation of response to stimulus", "Negative regulation of response to wounding", "Negative regulation of retinoic acid receptor signaling pathway", "Negative regulation of rho protein signal transduction", "Negative regulation of rig i signaling pathway", "Negative regulation of rna catabolic process", "Negative regulation of rna splicing", "Negative regulation of ruffle assembly", "Negative regulation of ryanodine sensitive calcium release channel activity", "Negative regulation of schwann cell proliferation", "Negative regulation of secretion", "Negative regulation of signal transduction by p53 class mediator", "Negative regulation of signal transduction in absence of ligand", "Negative regulation of signaling", "Negative regulation of signaling receptor activity", "Negative regulation of single stranded viral rna replication via double stranded dna intermediate", "Negative regulation of sister chromatid cohesion", "Negative regulation of small gtpase mediated signal transduction", "Negative regulation of small molecule metabolic process", "Negative regulation of smooth muscle cell apoptotic process", "Negative regulation of smooth muscle cell differentiation", "Negative regulation of smooth muscle cell migration", "Negative regulation of smooth muscle cell proliferation", "Negative regulation of smoothened signaling pathway", "Negative regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Negative regulation of sodium ion transmembrane transport", "Negative regulation of sodium ion transport", "Negative regulation of stem cell differentiation", "Negative regulation of steroid metabolic process", "Negative regulation of stress activated protein kinase signaling cascade", "Negative regulation of striated muscle cell apoptotic process", "Negative regulation of striated muscle cell differentiation", "Negative regulation of striated muscle contraction", "Negative regulation of supramolecular fiber organization", "Negative regulation of synapse assembly", "Negative regulation of synapse organization", "Negative regulation of synaptic transmission", "Negative regulation of synaptic transmission glutamatergic", "Negative regulation of synaptic vesicle exocytosis", "Negative regulation of systemic arterial blood pressure", "Negative regulation of t cell apoptotic process", "Negative regulation of t cell differentiation", "Negative regulation of t cell proliferation", "Negative regulation of t cell receptor signaling pathway", "Negative regulation of t helper cell differentiation", "Negative regulation of telomerase activity", "Negative regulation of telomere capping", "Negative regulation of telomere maintenance", "Negative regulation of telomere maintenance via telomerase", "Negative regulation of telomere maintenance via telomere lengthening", "Negative regulation of tissue remodeling", "Negative regulation of toll like receptor signaling pathway", "Negative regulation of tor signaling", "Negative regulation of transcription by competitive promoter binding", "Negative regulation of transcription by rna polymerase i", "Negative regulation of transcription by rna polymerase ii", "Negative regulation of transcription from rna polymerase ii promoter in response to stress", "Negative regulation of transcription initiation from rna polymerase ii promoter", "Negative regulation of transcription regulatory region dna binding", "Negative regulation of transferase activity", "Negative regulation of transforming growth factor beta production", "Negative regulation of transforming growth factor beta receptor signaling pathway", "Negative regulation of transforming growth factor beta1 production", "Negative regulation of translational elongation", "Negative regulation of translational initiation", "Negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Negative regulation of transmembrane transport", "Negative regulation of transport", "Negative regulation of transporter activity", "Negative regulation of trophoblast cell migration", "Negative regulation of tumor necrosis factor superfamily cytokine production", "Negative regulation of type 2 immune response", "Negative regulation of type b pancreatic cell apoptotic process", "Negative regulation of type i interferon mediated signaling pathway", "Negative regulation of type i interferon production", "Negative regulation of tyrosine phosphorylation of stat protein", "Negative regulation of ubiquitin dependent protein catabolic process", "Negative regulation of ubiquitin protein ligase activity", "Negative regulation of ubiquitin protein transferase activity", "Negative regulation of vascular associated smooth muscle cell apoptotic process", "Negative regulation of vascular associated smooth muscle cell differentiation", "Negative regulation of vascular associated smooth muscle cell migration", "Negative regulation of vascular associated smooth muscle cell proliferation", "Negative regulation of vascular endothelial growth factor production", "Negative regulation of vascular endothelial growth factor receptor signaling pathway", "Negative regulation of vascular permeability", "Negative regulation of vascular wound healing", "Negative regulation of vasculature development", "Negative regulation of viral entry into host cell", "Negative regulation of viral genome replication", "Negative regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Negative regulation of viral life cycle", "Negative regulation of viral process", "Negative regulation of viral transcription", "Negative regulation of vitamin metabolic process", "Negative regulation of voltage gated calcium channel activity", "Negative regulation of voltage gated potassium channel activity", "Negative regulation of wnt signaling pathway", "Negative regulation of wound healing", "Nephric duct development", "Nephric duct morphogenesis", "Nephron development", "Nephron epithelium development", "Nephron morphogenesis", "Nephron tubule epithelial cell differentiation", "Nephron tubule formation", "Nerve development", "Nerve growth factor signaling pathway", "Nervous system process", "Nervous system process involved in regulation of systemic arterial blood pressure", "Neural crest cell differentiation", "Neural crest cell migration", "Neural crest formation", "Neural nucleus development", "Neural plate development", "Neural precursor cell proliferation", "Neural retina development", "Neural tube development", "Neural tube formation", "Neural tube patterning", "Neuroblast division", "Neuroblast proliferation", "Neuroendocrine cell differentiation", "Neuroepithelial cell differentiation", "Neurofilament cytoskeleton organization", "Neurogenesis", "Neuroinflammatory response", "Neuromuscular junction development", "Neuromuscular process", "Neuromuscular process controlling balance", "Neuromuscular process controlling posture", "Neuromuscular synaptic transmission", "Neuron apoptotic process", "Neuron cellular homeostasis", "Neuron death", "Neuron death in response to hydrogen peroxide", "Neuron death in response to oxidative stress", "Neuron development", "Neuron differentiation", "Neuron fate commitment", "Neuron fate determination", "Neuron intrinsic apoptotic signaling pathway in response to oxidative stress", "Neuron maturation", "Neuron migration", "Neuron projection arborization", "Neuron projection extension", "Neuron projection extension involved in neuron projection guidance", "Neuron projection guidance", "Neuron projection maintenance", "Neuron projection organization", "Neuron projection regeneration", "Neuron recognition", "Neuron remodeling", "Neuronal action potential", "Neuronal ion channel clustering", "Neuronal stem cell population maintenance", "Neuropeptide signaling pathway", "Neurotransmitter biosynthetic process", "Neurotransmitter catabolic process", "Neurotransmitter gated ion channel clustering", "Neurotransmitter metabolic process", "Neurotransmitter receptor internalization", "Neurotransmitter receptor localization to postsynaptic specialization membrane", "Neurotransmitter receptor transport", "Neurotransmitter receptor transport endosome to postsynaptic membrane", "Neurotransmitter receptor transport postsynaptic endosome to lysosome", "Neurotransmitter receptor transport to plasma membrane", "Neurotransmitter reuptake", "Neurotransmitter secretion", "Neurotransmitter transport", "Neurotransmitter uptake", "Neurotrophin production", "Neurotrophin signaling pathway", "Neurotrophin trk receptor signaling pathway", "Neutral amino acid transport", "Neutral lipid biosynthetic process", "Neutral lipid catabolic process", "Neutral lipid metabolic process", "Neutrophil activation involved in immune response", "Neutrophil apoptotic process", "Neutrophil chemotaxis", "Neutrophil clearance", "Neutrophil degranulation", "Neutrophil differentiation", "Neutrophil homeostasis", "Neutrophil mediated immunity", "Neutrophil migration", "Nik nf kappab signaling", "Nitric oxide mediated signal transduction", "Nitric oxide synthase biosynthetic process", "Nitrogen compound transport", "Nk t cell activation", "Nk t cell differentiation", "Nls bearing protein import into nucleus", "Non canonical wnt signaling pathway", "Non lytic viral release", "Non membrane bounded organelle assembly", "Non motile cilium assembly", "Nonribosomal peptide biosynthetic process", "Nose development", "Notch receptor processing", "Notch signaling pathway", "Nuclear body organization", "Nuclear chromosome segregation", "Nuclear envelope organization", "Nuclear export", "Nuclear membrane organization", "Nuclear membrane reassembly", "Nuclear migration", "Nuclear ncrna surveillance", "Nuclear pore complex assembly", "Nuclear pore organization", "Nuclear transcribed mrna catabolic process", "Nuclear transcribed mrna catabolic process deadenylation dependent decay", "Nuclear transcribed mrna catabolic process deadenylation independent decay", "Nuclear transcribed mrna catabolic process exonucleolytic", "Nuclear transcribed mrna catabolic process exonucleolytic 3 5", "Nuclear transcribed mrna catabolic process nonsense mediated decay", "Nuclear transcribed mrna poly a tail shortening", "Nuclear transport", "Nucleic acid phosphodiester bond hydrolysis", "Nucleobase biosynthetic process", "Nucleobase catabolic process", "Nucleobase containing compound transport", "Nucleobase containing small molecule biosynthetic process", "Nucleobase containing small molecule catabolic process", "Nucleobase containing small molecule interconversion", "Nucleobase containing small molecule metabolic process", "Nucleobase metabolic process", "Nucleobase transport", "Nucleolar chromatin organization", "Nucleolar large rrna transcription by rna polymerase i", "Nucleolus organization", "Nucleoside bisphosphate biosynthetic process", "Nucleoside bisphosphate catabolic process", "Nucleoside bisphosphate metabolic process", "Nucleoside catabolic process", "Nucleoside diphosphate biosynthetic process", "Nucleoside diphosphate catabolic process", "Nucleoside diphosphate metabolic process", "Nucleoside metabolic process", "Nucleoside monophosphate biosynthetic process", "Nucleoside monophosphate catabolic process", "Nucleoside monophosphate metabolic process", "Nucleoside monophosphate phosphorylation", "Nucleoside phosphate biosynthetic process", "Nucleoside phosphate catabolic process", "Nucleoside salvage", "Nucleoside triphosphate biosynthetic process", "Nucleoside triphosphate catabolic process", "Nucleoside triphosphate metabolic process", "Nucleosome assembly", "Nucleosome mobilization", "Nucleosome organization", "Nucleosome positioning", "Nucleotide binding domain leucine rich repeat containing receptor signaling pathway", "Nucleotide binding oligomerization domain containing 2 signaling pathway", "Nucleotide excision repair", "Nucleotide excision repair dna gap filling", "Nucleotide excision repair dna incision", "Nucleotide phosphorylation", "Nucleotide salvage", "Nucleotide sugar biosynthetic process", "Nucleotide sugar metabolic process", "Nucleotide sugar transmembrane transport", "Nucleotide transmembrane transport", "Nucleotide transport", "Nucleus localization", "Nucleus organization", "O glycan processing", "Observational learning", "Odontoblast differentiation", "Odontogenesis", "Odontogenesis of dentin containing tooth", "Olefinic compound biosynthetic process", "Olefinic compound metabolic process", "Olfactory behavior", "Olfactory bulb interneuron development", "Olfactory bulb interneuron differentiation", "Olfactory lobe development", "Oligodendrocyte development", "Oligodendrocyte differentiation", "Oligodendrocyte progenitor proliferation", "Oligopeptide transport", "Oligosaccharide catabolic process", "Oligosaccharide lipid intermediate biosynthetic process", "Oligosaccharide metabolic process", "One carbon metabolic process", "Oocyte construction", "Oocyte differentiation", "Oocyte maturation", "Oogenesis", "Optic nerve development", "Organ growth", "Organ induction", "Organ or tissue specific immune response", "Organelle assembly", "Organelle disassembly", "Organelle fission", "Organelle fusion", "Organelle inheritance", "Organelle localization", "Organelle membrane fusion", "Organelle transport along microtubule", "Organic acid biosynthetic process", "Organic acid catabolic process", "Organic acid metabolic process", "Organic acid transmembrane transport", "Organic acid transport", "Organic anion transport", "Organic cation transport", "Organic cyclic compound catabolic process", "Organic hydroxy compound biosynthetic process", "Organic hydroxy compound catabolic process", "Organic hydroxy compound metabolic process", "Organic hydroxy compound transport", "Organism emergence from protective structure", "Organonitrogen compound biosynthetic process", "Organonitrogen compound catabolic process", "Organophosphate biosynthetic process", "Organophosphate catabolic process", "Organophosphate ester transport", "Organophosphate metabolic process", "Ornithine metabolic process", "Ornithine transport", "Ossification", "Osteoblast differentiation", "Osteoblast proliferation", "Osteoclast development", "Osteoclast differentiation", "Otolith development", "Outer dynein arm assembly", "Outer mitochondrial membrane organization", "Outflow tract morphogenesis", "Ovarian follicle development", "Oviduct development", "Ovulation cycle", "Ovulation cycle process", "Oxaloacetate metabolic process", "Oxaloacetate transport", "Oxidative demethylation", "Oxidative dna demethylation", "Oxidative phosphorylation", "Oxidative rna demethylation", "Oxygen homeostasis", "P body assembly", "P38mapk cascade", "Pallium development", "Pancreas development", "Pancreatic juice secretion", "Pantothenate metabolic process", "Parallel actin filament bundle assembly", "Paranodal junction assembly", "Parathyroid gland development", "Paraxial mesoderm development", "Paraxial mesoderm formation", "Paraxial mesoderm morphogenesis", "Parkin mediated stimulation of mitophagy in response to mitochondrial depolarization", "Pathway restricted smad protein phosphorylation", "Pattern recognition receptor signaling pathway", "Pattern specification process", "Penetration of zona pellucida", "Pentose catabolic process", "Pentose metabolic process", "Pentose phosphate shunt", "Pentose phosphate shunt non oxidative branch", "Peptide antigen assembly with mhc protein complex", "Peptide biosynthetic process", "Peptide catabolic process", "Peptide cross linking", "Peptide metabolic process", "Peptide transport", "Peptidyl amino acid modification", "Peptidyl arginine methylation", "Peptidyl arginine methylation to asymmetrical dimethyl arginine", "Peptidyl arginine modification", "Peptidyl arginine n methylation", "Peptidyl asparagine modification", "Peptidyl cysteine modification", "Peptidyl diphthamide biosynthetic process from peptidyl histidine", "Peptidyl glutamic acid modification", "Peptidyl glutamine methylation", "Peptidyl histidine modification", "Peptidyl l cysteine s palmitoylation", "Peptidyl lysine acetylation", "Peptidyl lysine deacetylation", "Peptidyl lysine dimethylation", "Peptidyl lysine hydroxylation", "Peptidyl lysine methylation", "Peptidyl lysine modification", "Peptidyl lysine trimethylation", "Peptidyl methionine modification", "Peptidyl proline hydroxylation", "Peptidyl proline hydroxylation to 4 hydroxy l proline", "Peptidyl proline modification", "Peptidyl serine autophosphorylation", "Peptidyl serine dephosphorylation", "Peptidyl serine modification", "Peptidyl threonine dephosphorylation", "Peptidyl threonine modification", "Peptidyl tyrosine dephosphorylation", "Peptidyl tyrosine dephosphorylation involved in inactivation of protein kinase activity", "Peptidyl tyrosine modification", "Peripheral nervous system axon regeneration", "Peripheral nervous system development", "Peripheral nervous system myelin maintenance", "Perk mediated unfolded protein response", "Peroxisomal transport", "Peroxisome fission", "Peroxisome organization", "Peroxisome proliferator activated receptor signaling pathway", "Ph reduction", "Phagocytosis", "Phagocytosis recognition", "Phagolysosome assembly", "Phagosome acidification", "Phagosome lysosome fusion", "Phagosome maturation", "Pharyngeal system development", "Phenol containing compound biosynthetic process", "Phenol containing compound catabolic process", "Phenol containing compound metabolic process", "Phenotypic switching", "Phosphagen metabolic process", "Phosphate ion transmembrane transport", "Phosphate ion transport", "Phosphatidic acid metabolic process", "Phosphatidylcholine acyl chain remodeling", "Phosphatidylcholine biosynthetic process", "Phosphatidylcholine catabolic process", "Phosphatidylcholine metabolic process", "Phosphatidylethanolamine biosynthetic process", "Phosphatidylethanolamine metabolic process", "Phosphatidylglycerol acyl chain remodeling", "Phosphatidylglycerol biosynthetic process", "Phosphatidylglycerol metabolic process", "Phosphatidylinositol 3 kinase signaling", "Phosphatidylinositol acyl chain remodeling", "Phosphatidylinositol biosynthetic process", "Phosphatidylinositol dephosphorylation", "Phosphatidylinositol metabolic process", "Phosphatidylinositol phosphate biosynthetic process", "Phosphatidylserine metabolic process", "Phospholipase c activating dopamine receptor signaling pathway", "Phospholipase c activating g protein coupled receptor signaling pathway", "Phospholipid biosynthetic process", "Phospholipid catabolic process", "Phospholipid dephosphorylation", "Phospholipid metabolic process", "Phospholipid transport", "Phosphorylation", "Phosphorylation of rna polymerase ii c terminal domain", "Photoperiodism", "Photoreceptor cell development", "Photoreceptor cell differentiation", "Photoreceptor cell maintenance", "Photoreceptor cell outer segment organization", "Phototransduction", "Phototransduction visible light", "Physiological cardiac muscle hypertrophy", "Pigment accumulation", "Pigment biosynthetic process", "Pigment cell differentiation", "Pigment granule localization", "Pigment granule maturation", "Pigment granule organization", "Pigment metabolic process", "Pigmentation", "Pinocytosis", "Pirna metabolic process", "Pituitary gland development", "Placenta blood vessel development", "Placenta development", "Planar cell polarity pathway involved in neural tube closure", "Plasma lipoprotein particle clearance", "Plasma membrane fusion", "Plasma membrane organization", "Plasma membrane raft assembly", "Plasma membrane raft organization", "Plasma membrane repair", "Plasma membrane to endosome transport", "Plasma membrane tubulation", "Plasminogen activation", "Platelet activating factor metabolic process", "Platelet activation", "Platelet aggregation", "Platelet degranulation", "Platelet derived growth factor receptor beta signaling pathway", "Platelet derived growth factor receptor signaling pathway", "Platelet morphogenesis", "Plus end directed organelle transport along microtubule", "Pml body organization", "Podosome assembly", "Pointed end actin filament capping", "Polarized epithelial cell differentiation", "Poly a plus mrna export from nucleus", "Poly n acetyllactosamine metabolic process", "Polyadenylation dependent rna catabolic process", "Polyadenylation dependent snorna 3 end processing", "Polyamine biosynthetic process", "Polyamine metabolic process", "Polyketide metabolic process", "Polyol biosynthetic process", "Polyol catabolic process", "Polyol metabolic process", "Polyprenol metabolic process", "Polysaccharide biosynthetic process", "Polysaccharide catabolic process", "Polysaccharide metabolic process", "Pons development", "Pore complex assembly", "Porphyrin containing compound metabolic process", "Positive chemotaxis", "Positive regulation by host of viral genome replication", "Positive regulation by host of viral process", "Positive regulation by host of viral transcription", "Positive regulation by symbiont of entry into host", "Positive regulation of 3 utr mediated mrna stabilization", "Positive regulation of actin cytoskeleton reorganization", "Positive regulation of actin filament bundle assembly", "Positive regulation of actin filament depolymerization", "Positive regulation of actin filament polymerization", "Positive regulation of actin nucleation", "Positive regulation of action potential", "Positive regulation of activated t cell proliferation", "Positive regulation of activin receptor signaling pathway", "Positive regulation of acute inflammatory response", "Positive regulation of acute inflammatory response to antigenic stimulus", "Positive regulation of adaptive immune response", "Positive regulation of alcohol biosynthetic process", "Positive regulation of alpha beta t cell activation", "Positive regulation of alpha beta t cell differentiation", "Positive regulation of alpha beta t cell proliferation", "Positive regulation of amine transport", "Positive regulation of amino acid transport", "Positive regulation of amyloid beta clearance", "Positive regulation of amyloid beta formation", "Positive regulation of amyloid precursor protein biosynthetic process", "Positive regulation of amyloid precursor protein catabolic process", "Positive regulation of animal organ morphogenesis", "Positive regulation of anion transmembrane transport", "Positive regulation of anion transport", "Positive regulation of anoikis", "Positive regulation of antigen receptor mediated signaling pathway", "Positive regulation of apoptotic signaling pathway", "Positive regulation of arp2 3 complex mediated actin nucleation", "Positive regulation of aspartic type peptidase activity", "Positive regulation of astrocyte differentiation", "Positive regulation of atp biosynthetic process", "Positive regulation of atp dependent activity", "Positive regulation of atp metabolic process", "Positive regulation of attachment of spindle microtubules to kinetochore", "Positive regulation of autophagy", "Positive regulation of autophagy of mitochondrion", "Positive regulation of axon extension", "Positive regulation of axonogenesis", "Positive regulation of b cell activation", "Positive regulation of b cell mediated immunity", "Positive regulation of b cell proliferation", "Positive regulation of basement membrane assembly involved in embryonic body morphogenesis", "Positive regulation of behavior", "Positive regulation of binding", "Positive regulation of biomineralization", "Positive regulation of blood brain barrier permeability", "Positive regulation of blood circulation", "Positive regulation of blood pressure", "Positive regulation of blood vessel endothelial cell migration", "Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Positive regulation of bmp signaling pathway", "Positive regulation of bone mineralization", "Positive regulation of bone resorption", "Positive regulation of brown fat cell differentiation", "Positive regulation of calcineurin mediated signaling", "Positive regulation of calcium ion dependent exocytosis", "Positive regulation of calcium ion transmembrane transport", "Positive regulation of calcium ion transmembrane transporter activity", "Positive regulation of calcium ion transport", "Positive regulation of calcium ion transport into cytosol", "Positive regulation of calcium mediated signaling", "Positive regulation of camp dependent protein kinase activity", "Positive regulation of canonical wnt signaling pathway", "Positive regulation of carbohydrate metabolic process", "Positive regulation of cardiac muscle cell proliferation", "Positive regulation of cardioblast differentiation", "Positive regulation of cardiocyte differentiation", "Positive regulation of cartilage development", "Positive regulation of catabolic process", "Positive regulation of catalytic activity", "Positive regulation of catecholamine metabolic process", "Positive regulation of cation channel activity", "Positive regulation of cd4 positive alpha beta t cell activation", "Positive regulation of cd4 positive alpha beta t cell differentiation", "Positive regulation of cd8 positive alpha beta t cell activation", "Positive regulation of cell activation", "Positive regulation of cell adhesion", "Positive regulation of cell adhesion molecule production", "Positive regulation of cell aging", "Positive regulation of cell cell adhesion", "Positive regulation of cell cell adhesion mediated by cadherin", "Positive regulation of cell cycle", "Positive regulation of cell cycle checkpoint", "Positive regulation of cell cycle g1 s phase transition", "Positive regulation of cell cycle g2 m phase transition", "Positive regulation of cell cycle phase transition", "Positive regulation of cell cycle process", "Positive regulation of cell death", "Positive regulation of cell development", "Positive regulation of cell differentiation", "Positive regulation of cell division", "Positive regulation of cell growth", "Positive regulation of cell growth involved in cardiac muscle cell development", "Positive regulation of cell junction assembly", "Positive regulation of cell killing", "Positive regulation of cell matrix adhesion", "Positive regulation of cell maturation", "Positive regulation of cell migration by vascular endothelial growth factor signaling pathway", "Positive regulation of cell migration involved in sprouting angiogenesis", "Positive regulation of cell morphogenesis involved in differentiation", "Positive regulation of cell population proliferation", "Positive regulation of cell projection organization", "Positive regulation of cell size", "Positive regulation of cell substrate adhesion", "Positive regulation of cell substrate junction organization", "Positive regulation of cellular amide metabolic process", "Positive regulation of cellular amine metabolic process", "Positive regulation of cellular biosynthetic process", "Positive regulation of cellular carbohydrate metabolic process", "Positive regulation of cellular component biogenesis", "Positive regulation of cellular component organization", "Positive regulation of cellular protein catabolic process", "Positive regulation of cellular respiration", "Positive regulation of cellular response to insulin stimulus", "Positive regulation of cellular response to transforming growth factor beta stimulus", "Positive regulation of centriole elongation", "Positive regulation of centriole replication", "Positive regulation of chemokine c c motif ligand 5 production", "Positive regulation of chemokine c x c motif ligand 2 production", "Positive regulation of chemokine production", "Positive regulation of chemotaxis", "Positive regulation of cholesterol biosynthetic process", "Positive regulation of cholesterol metabolic process", "Positive regulation of cholesterol storage", "Positive regulation of chondrocyte differentiation", "Positive regulation of chromatin binding", "Positive regulation of chromatin organization", "Positive regulation of chromosome condensation", "Positive regulation of chromosome organization", "Positive regulation of chromosome segregation", "Positive regulation of chromosome separation", "Positive regulation of cilium assembly", "Positive regulation of circadian rhythm", "Positive regulation of clathrin dependent endocytosis", "Positive regulation of coagulation", "Positive regulation of cold induced thermogenesis", "Positive regulation of collagen metabolic process", "Positive regulation of collateral sprouting", "Positive regulation of complement activation", "Positive regulation of connective tissue replacement", "Positive regulation of cyclic nucleotide phosphodiesterase activity", "Positive regulation of cyclin dependent protein kinase activity", "Positive regulation of cysteine type endopeptidase activity", "Positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Positive regulation of cytokine production", "Positive regulation of cytokine production involved in immune response", "Positive regulation of cytokine production involved in inflammatory response", "Positive regulation of cytokinesis", "Positive regulation of cytoplasmic translation", "Positive regulation of cytoplasmic transport", "Positive regulation of cytoskeleton organization", "Positive regulation of defense response", "Positive regulation of defense response to virus by host", "Positive regulation of dendrite development", "Positive regulation of dendrite morphogenesis", "Positive regulation of dendritic cell cytokine production", "Positive regulation of dendritic cell differentiation", "Positive regulation of dendritic spine development", "Positive regulation of dendritic spine morphogenesis", "Positive regulation of deoxyribonuclease activity", "Positive regulation of dephosphorylation", "Positive regulation of developmental growth", "Positive regulation of developmental process", "Positive regulation of dna binding", "Positive regulation of dna binding transcription factor activity", "Positive regulation of dna biosynthetic process", "Positive regulation of dna damage response signal transduction by p53 class mediator", "Positive regulation of dna demethylation", "Positive regulation of dna dependent dna replication", "Positive regulation of dna ligation", "Positive regulation of dna metabolic process", "Positive regulation of dna methylation dependent heterochromatin assembly", "Positive regulation of dna recombination", "Positive regulation of dna repair", "Positive regulation of dna replication", "Positive regulation of dna templated transcription elongation", "Positive regulation of dna templated transcription initiation", "Positive regulation of dopamine receptor signaling pathway", "Positive regulation of double strand break repair", "Positive regulation of double strand break repair via homologous recombination", "Positive regulation of double strand break repair via nonhomologous end joining", "Positive regulation of early endosome to late endosome transport", "Positive regulation of embryonic development", "Positive regulation of endocytic recycling", "Positive regulation of endocytosis", "Positive regulation of endoplasmic reticulum unfolded protein response", "Positive regulation of endothelial cell apoptotic process", "Positive regulation of endothelial cell chemotaxis", "Positive regulation of endothelial cell chemotaxis by vegf activated vascular endothelial growth factor receptor signaling pathway", "Positive regulation of endothelial cell development", "Positive regulation of endothelial cell differentiation", "Positive regulation of endothelial cell matrix adhesion via fibronectin", "Positive regulation of endothelial cell migration", "Positive regulation of endothelial cell proliferation", "Positive regulation of epidermal cell differentiation", "Positive regulation of epidermal growth factor activated receptor activity", "Positive regulation of epidermis development", "Positive regulation of epithelial cell apoptotic process", "Positive regulation of epithelial cell differentiation", "Positive regulation of epithelial cell migration", "Positive regulation of epithelial cell proliferation", "Positive regulation of epithelial cell proliferation involved in lung morphogenesis", "Positive regulation of epithelial to mesenchymal transition", "Positive regulation of er associated ubiquitin dependent protein catabolic process", "Positive regulation of erad pathway", "Positive regulation of erbb signaling pathway", "Positive regulation of erk1 and erk2 cascade", "Positive regulation of erythrocyte differentiation", "Positive regulation of establishment of protein localization", "Positive regulation of establishment of protein localization to mitochondrion", "Positive regulation of establishment of protein localization to telomere", "Positive regulation of excitatory postsynaptic potential", "Positive regulation of execution phase of apoptosis", "Positive regulation of exocytosis", "Positive regulation of exosomal secretion", "Positive regulation of extracellular matrix assembly", "Positive regulation of extracellular matrix disassembly", "Positive regulation of extracellular matrix organization", "Positive regulation of extrinsic apoptotic signaling pathway", "Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Positive regulation of fat cell differentiation", "Positive regulation of fatty acid beta oxidation", "Positive regulation of fatty acid biosynthetic process", "Positive regulation of fatty acid metabolic process", "Positive regulation of fatty acid oxidation", "Positive regulation of fatty acid transport", "Positive regulation of fc receptor mediated stimulatory signaling pathway", "Positive regulation of feeding behavior", "Positive regulation of fibroblast growth factor receptor signaling pathway", "Positive regulation of fibroblast migration", "Positive regulation of fibroblast proliferation", "Positive regulation of filopodium assembly", "Positive regulation of focal adhesion assembly", "Positive regulation of g protein coupled receptor signaling pathway", "Positive regulation of g0 to g1 transition", "Positive regulation of g1 s transition of mitotic cell cycle", "Positive regulation of gastrulation", "Positive regulation of gene expression", "Positive regulation of glial cell differentiation", "Positive regulation of glial cell migration", "Positive regulation of glial cell proliferation", "Positive regulation of gliogenesis", "Positive regulation of glucokinase activity", "Positive regulation of gluconeogenesis", "Positive regulation of glucose import", "Positive regulation of glucose metabolic process", "Positive regulation of glucose transmembrane transport", "Positive regulation of glutamate secretion", "Positive regulation of glycogen metabolic process", "Positive regulation of glycogen starch synthase activity", "Positive regulation of glycolytic process", "Positive regulation of glycoprotein metabolic process", "Positive regulation of golgi to plasma membrane protein transport", "Positive regulation of gonad development", "Positive regulation of granulocyte chemotaxis", "Positive regulation of granulocyte differentiation", "Positive regulation of growth", "Positive regulation of gtpase activity", "Positive regulation of hair follicle development", "Positive regulation of heart growth", "Positive regulation of heart rate", "Positive regulation of helicase activity", "Positive regulation of hematopoietic progenitor cell differentiation", "Positive regulation of hemopoiesis", "Positive regulation of heterotypic cell cell adhesion", "Positive regulation of hexokinase activity", "Positive regulation of hippo signaling", "Positive regulation of histone acetylation", "Positive regulation of histone deacetylation", "Positive regulation of histone h3 k27 methylation", "Positive regulation of histone h3 k4 methylation", "Positive regulation of histone h3 k9 acetylation", "Positive regulation of histone h3 k9 methylation", "Positive regulation of histone h4 acetylation", "Positive regulation of histone methylation", "Positive regulation of histone modification", "Positive regulation of histone phosphorylation", "Positive regulation of histone ubiquitination", "Positive regulation of homotypic cell cell adhesion", "Positive regulation of hormone biosynthetic process", "Positive regulation of hormone metabolic process", "Positive regulation of hormone secretion", "Positive regulation of humoral immune response", "Positive regulation of hydrogen peroxide metabolic process", "Positive regulation of hydrolase activity", "Positive regulation of i kappab kinase nf kappab signaling", "Positive regulation of i kappab phosphorylation", "Positive regulation of immune effector process", "Positive regulation of immune response", "Positive regulation of immune system process", "Positive regulation of immunoglobulin production", "Positive regulation of inclusion body assembly", "Positive regulation of inflammatory response", "Positive regulation of inflammatory response to antigenic stimulus", "Positive regulation of innate immune response", "Positive regulation of insulin like growth factor receptor signaling pathway", "Positive regulation of insulin secretion", "Positive regulation of insulin secretion involved in cellular response to glucose stimulus", "Positive regulation of integrin activation", "Positive regulation of integrin mediated signaling pathway", "Positive regulation of interferon alpha production", "Positive regulation of interferon beta production", "Positive regulation of interferon gamma production", "Positive regulation of interleukin 1 beta production", "Positive regulation of interleukin 1 production", "Positive regulation of interleukin 10 production", "Positive regulation of interleukin 12 production", "Positive regulation of interleukin 17 production", "Positive regulation of interleukin 18 production", "Positive regulation of interleukin 2 production", "Positive regulation of interleukin 6 production", "Positive regulation of interleukin 8 production", "Positive regulation of intracellular lipid transport", "Positive regulation of intracellular protein transport", "Positive regulation of intracellular signal transduction", "Positive regulation of intracellular steroid hormone receptor signaling pathway", "Positive regulation of intracellular transport", "Positive regulation of intrinsic apoptotic signaling pathway", "Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Positive regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Positive regulation of ion transmembrane transport", "Positive regulation of ion transport", "Positive regulation of ire1 mediated unfolded protein response", "Positive regulation of isotype switching", "Positive regulation of isotype switching to iga isotypes", "Positive regulation of isotype switching to igg isotypes", "Positive regulation of jnk cascade", "Positive regulation of jun kinase activity", "Positive regulation of keratinocyte differentiation", "Positive regulation of keratinocyte proliferation", "Positive regulation of kinase activity", "Positive regulation of lamellipodium assembly", "Positive regulation of lamellipodium morphogenesis", "Positive regulation of lamellipodium organization", "Positive regulation of leukocyte adhesion to vascular endothelial cell", "Positive regulation of leukocyte apoptotic process", "Positive regulation of leukocyte cell cell adhesion", "Positive regulation of leukocyte chemotaxis", "Positive regulation of leukocyte degranulation", "Positive regulation of leukocyte mediated immunity", "Positive regulation of leukocyte migration", "Positive regulation of leukocyte proliferation", "Positive regulation of ligase activity", "Positive regulation of lipase activity", "Positive regulation of lipid biosynthetic process", "Positive regulation of lipid catabolic process", "Positive regulation of lipid kinase activity", "Positive regulation of lipid localization", "Positive regulation of lipid metabolic process", "Positive regulation of lipid storage", "Positive regulation of lipid transport", "Positive regulation of lipopolysaccharide mediated signaling pathway", "Positive regulation of lipoprotein particle clearance", "Positive regulation of locomotion", "Positive regulation of long term neuronal synaptic plasticity", "Positive regulation of long term synaptic depression", "Positive regulation of long term synaptic potentiation", "Positive regulation of low density lipoprotein receptor activity", "Positive regulation of lyase activity", "Positive regulation of lymphocyte anergy", "Positive regulation of lymphocyte apoptotic process", "Positive regulation of lymphocyte chemotaxis", "Positive regulation of lymphocyte differentiation", "Positive regulation of lymphocyte mediated immunity", "Positive regulation of lymphocyte migration", "Positive regulation of macroautophagy", "Positive regulation of macrophage activation", "Positive regulation of macrophage differentiation", "Positive regulation of maintenance of sister chromatid cohesion", "Positive regulation of mammary gland epithelial cell proliferation", "Positive regulation of map kinase activity", "Positive regulation of mapk cascade", "Positive regulation of mast cell activation", "Positive regulation of mast cell activation involved in immune response", "Positive regulation of megakaryocyte differentiation", "Positive regulation of meiotic cell cycle", "Positive regulation of meiotic nuclear division", "Positive regulation of membrane depolarization", "Positive regulation of membrane permeability", "Positive regulation of membrane potential", "Positive regulation of membrane protein ectodomain proteolysis", "Positive regulation of mesenchymal cell proliferation", "Positive regulation of mesenchymal stem cell proliferation", "Positive regulation of metalloendopeptidase activity", "Positive regulation of metallopeptidase activity", "Positive regulation of metaphase anaphase transition of cell cycle", "Positive regulation of mhc class i biosynthetic process", "Positive regulation of microtubule binding", "Positive regulation of microtubule nucleation", "Positive regulation of microtubule polymerization or depolymerization", "Positive regulation of mirna catabolic process", "Positive regulation of mirna mediated gene silencing by inhibition of translation", "Positive regulation of mirna metabolic process", "Positive regulation of mirna transcription", "Positive regulation of mitochondrial calcium ion concentration", "Positive regulation of mitochondrial depolarization", "Positive regulation of mitochondrial fission", "Positive regulation of mitochondrial membrane potential", "Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Positive regulation of mitochondrial translation", "Positive regulation of mitochondrion organization", "Positive regulation of mitophagy", "Positive regulation of mitophagy in response to mitochondrial depolarization", "Positive regulation of mitotic cell cycle", "Positive regulation of mitotic cell cycle phase transition", "Positive regulation of mitotic cell cycle spindle assembly checkpoint", "Positive regulation of mitotic nuclear division", "Positive regulation of molecular function", "Positive regulation of monocyte chemotaxis", "Positive regulation of monocyte differentiation", "Positive regulation of mononuclear cell migration", "Positive regulation of monooxygenase activity", "Positive regulation of morphogenesis of an epithelium", "Positive regulation of mrna 3 end processing", "Positive regulation of mrna metabolic process", "Positive regulation of mrna processing", "Positive regulation of mrna splicing via spliceosome", "Positive regulation of multicellular organism growth", "Positive regulation of multicellular organismal process", "Positive regulation of muscle cell apoptotic process", "Positive regulation of muscle cell differentiation", "Positive regulation of muscle contraction", "Positive regulation of muscle hypertrophy", "Positive regulation of muscle tissue development", "Positive regulation of myelination", "Positive regulation of myeloid cell apoptotic process", "Positive regulation of myeloid cell differentiation", "Positive regulation of myeloid leukocyte cytokine production involved in immune response", "Positive regulation of myeloid leukocyte differentiation", "Positive regulation of myeloid leukocyte mediated immunity", "Positive regulation of myoblast differentiation", "Positive regulation of myoblast fusion", "Positive regulation of myotube differentiation", "Positive regulation of nad p h oxidase activity", "Positive regulation of natural killer cell activation", "Positive regulation of natural killer cell mediated cytotoxicity", "Positive regulation of natural killer cell mediated immune response to tumor cell", "Positive regulation of natural killer cell mediated immunity", "Positive regulation of necrotic cell death", "Positive regulation of nervous system development", "Positive regulation of nervous system process", "Positive regulation of neural precursor cell proliferation", "Positive regulation of neuroblast proliferation", "Positive regulation of neurogenesis", "Positive regulation of neuron apoptotic process", "Positive regulation of neuron death", "Positive regulation of neuron differentiation", "Positive regulation of neuron migration", "Positive regulation of neuron projection arborization", "Positive regulation of neuron projection development", "Positive regulation of neuron projection regeneration", "Positive regulation of neurotransmitter secretion", "Positive regulation of neurotransmitter transport", "Positive regulation of neurotransmitter uptake", "Positive regulation of neurotrophin trk receptor signaling pathway", "Positive regulation of neutrophil migration", "Positive regulation of nf kappab transcription factor activity", "Positive regulation of nik nf kappab signaling", "Positive regulation of nitric oxide metabolic process", "Positive regulation of nitric oxide synthase activity", "Positive regulation of nitric oxide synthase biosynthetic process", "Positive regulation of nk t cell activation", "Positive regulation of nlrp3 inflammasome complex assembly", "Positive regulation of non motile cilium assembly", "Positive regulation of notch signaling pathway", "Positive regulation of nuclear cell cycle dna replication", "Positive regulation of nuclear division", "Positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Positive regulation of nuclease activity", "Positive regulation of nucleobase containing compound metabolic process", "Positive regulation of nucleobase containing compound transport", "Positive regulation of nucleocytoplasmic transport", "Positive regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Positive regulation of nucleotide binding oligomerization domain containing signaling pathway", "Positive regulation of nucleotide biosynthetic process", "Positive regulation of nucleotide metabolic process", "Positive regulation of oligodendrocyte differentiation", "Positive regulation of organ growth", "Positive regulation of organelle assembly", "Positive regulation of organelle organization", "Positive regulation of organic acid transport", "Positive regulation of ossification", "Positive regulation of osteoblast differentiation", "Positive regulation of oxidative stress induced cell death", "Positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Positive regulation of oxidative stress induced neuron death", "Positive regulation of oxidoreductase activity", "Positive regulation of p38mapk cascade", "Positive regulation of pathway restricted smad protein phosphorylation", "Positive regulation of pattern recognition receptor signaling pathway", "Positive regulation of peptidase activity", "Positive regulation of peptide secretion", "Positive regulation of peptidyl lysine acetylation", "Positive regulation of peptidyl serine phosphorylation", "Positive regulation of peptidyl threonine phosphorylation", "Positive regulation of peptidyl tyrosine phosphorylation", "Positive regulation of phagocytosis", "Positive regulation of phosphatase activity", "Positive regulation of phosphatidylinositol 3 kinase signaling", "Positive regulation of phospholipase a2 activity", "Positive regulation of phospholipase activity", "Positive regulation of phospholipid biosynthetic process", "Positive regulation of phospholipid metabolic process", "Positive regulation of phosphoprotein phosphatase activity", "Positive regulation of phosphorus metabolic process", "Positive regulation of pinocytosis", "Positive regulation of plasma membrane bounded cell projection assembly", "Positive regulation of plasminogen activation", "Positive regulation of platelet aggregation", "Positive regulation of podosome assembly", "Positive regulation of posttranscriptional gene silencing", "Positive regulation of potassium ion import across plasma membrane", "Positive regulation of potassium ion transmembrane transporter activity", "Positive regulation of potassium ion transport", "Positive regulation of production of mirnas involved in gene silencing by mirna", "Positive regulation of production of molecular mediator of immune response", "Positive regulation of programmed necrotic cell death", "Positive regulation of prostaglandin biosynthetic process", "Positive regulation of proteasomal ubiquitin dependent protein catabolic process", "Positive regulation of protein acetylation", "Positive regulation of protein autophosphorylation", "Positive regulation of protein binding", "Positive regulation of protein catabolic process", "Positive regulation of protein containing complex assembly", "Positive regulation of protein containing complex disassembly", "Positive regulation of protein deacetylation", "Positive regulation of protein dephosphorylation", "Positive regulation of protein depolymerization", "Positive regulation of protein deubiquitination", "Positive regulation of protein exit from endoplasmic reticulum", "Positive regulation of protein export from nucleus", "Positive regulation of protein glycosylation", "Positive regulation of protein import", "Positive regulation of protein k63 linked ubiquitination", "Positive regulation of protein kinase a signaling", "Positive regulation of protein kinase activity", "Positive regulation of protein kinase b signaling", "Positive regulation of protein localization", "Positive regulation of protein localization to cell cortex", "Positive regulation of protein localization to cell periphery", "Positive regulation of protein localization to cell surface", "Positive regulation of protein localization to centrosome", "Positive regulation of protein localization to cilium", "Positive regulation of protein localization to early endosome", "Positive regulation of protein localization to membrane", "Positive regulation of protein localization to nucleus", "Positive regulation of protein maturation", "Positive regulation of protein metabolic process", "Positive regulation of protein modification by small protein conjugation or removal", "Positive regulation of protein modification process", "Positive regulation of protein monoubiquitination", "Positive regulation of protein phosphorylation", "Positive regulation of protein polymerization", "Positive regulation of protein polyubiquitination", "Positive regulation of protein secretion", "Positive regulation of protein serine threonine kinase activity", "Positive regulation of protein sumoylation", "Positive regulation of protein targeting to membrane", "Positive regulation of protein tyrosine kinase activity", "Positive regulation of proteolysis", "Positive regulation of proteolysis involved in cellular protein catabolic process", "Positive regulation of pseudopodium assembly", "Positive regulation of reactive oxygen species biosynthetic process", "Positive regulation of reactive oxygen species metabolic process", "Positive regulation of receptor binding", "Positive regulation of receptor catabolic process", "Positive regulation of receptor clustering", "Positive regulation of receptor internalization", "Positive regulation of receptor mediated endocytosis", "Positive regulation of receptor recycling", "Positive regulation of receptor signaling pathway via stat", "Positive regulation of regulated secretory pathway", "Positive regulation of release of cytochrome c from mitochondria", "Positive regulation of release of sequestered calcium ion into cytosol", "Positive regulation of renal sodium excretion", "Positive regulation of reproductive process", "Positive regulation of respiratory burst", "Positive regulation of response to biotic stimulus", "Positive regulation of response to cytokine stimulus", "Positive regulation of response to dna damage stimulus", "Positive regulation of response to endoplasmic reticulum stress", "Positive regulation of response to external stimulus", "Positive regulation of response to oxidative stress", "Positive regulation of response to reactive oxygen species", "Positive regulation of response to tumor cell", "Positive regulation of response to wounding", "Positive regulation of retinoic acid receptor signaling pathway", "Positive regulation of rho protein signal transduction", "Positive regulation of rig i signaling pathway", "Positive regulation of rna binding", "Positive regulation of rna export from nucleus", "Positive regulation of rna metabolic process", "Positive regulation of rna polymerase ii transcription preinitiation complex assembly", "Positive regulation of rna splicing", "Positive regulation of rrna processing", "Positive regulation of ruffle assembly", "Positive regulation of ryanodine sensitive calcium release channel activity", "Positive regulation of secretion", "Positive regulation of sequestering of calcium ion", "Positive regulation of sequestering of triglyceride", "Positive regulation of signal transduction by p53 class mediator", "Positive regulation of signaling", "Positive regulation of signaling receptor activity", "Positive regulation of sister chromatid cohesion", "Positive regulation of skeletal muscle tissue development", "Positive regulation of smad protein signal transduction", "Positive regulation of small gtpase mediated signal transduction", "Positive regulation of small molecule metabolic process", "Positive regulation of smooth muscle cell apoptotic process", "Positive regulation of smooth muscle cell differentiation", "Positive regulation of smooth muscle cell migration", "Positive regulation of smooth muscle cell proliferation", "Positive regulation of smooth muscle contraction", "Positive regulation of smoothened signaling pathway", "Positive regulation of sodium ion transmembrane transport", "Positive regulation of sodium ion transmembrane transporter activity", "Positive regulation of sodium ion transport", "Positive regulation of spindle assembly", "Positive regulation of sprouting angiogenesis", "Positive regulation of stem cell differentiation", "Positive regulation of stem cell proliferation", "Positive regulation of steroid biosynthetic process", "Positive regulation of steroid hormone biosynthetic process", "Positive regulation of steroid metabolic process", "Positive regulation of sterol transport", "Positive regulation of stress activated protein kinase signaling cascade", "Positive regulation of stress fiber assembly", "Positive regulation of striated muscle cell apoptotic process", "Positive regulation of striated muscle cell differentiation", "Positive regulation of striated muscle contraction", "Positive regulation of substrate adhesion dependent cell spreading", "Positive regulation of supramolecular fiber organization", "Positive regulation of synapse assembly", "Positive regulation of synaptic plasticity", "Positive regulation of synaptic transmission", "Positive regulation of synaptic transmission gabaergic", "Positive regulation of synaptic transmission glutamatergic", "Positive regulation of synaptic vesicle endocytosis", "Positive regulation of synaptic vesicle exocytosis", "Positive regulation of synaptic vesicle recycling", "Positive regulation of syncytium formation by plasma membrane fusion", "Positive regulation of systemic arterial blood pressure", "Positive regulation of t cell apoptotic process", "Positive regulation of t cell cytokine production", "Positive regulation of t cell mediated cytotoxicity", "Positive regulation of t cell mediated immune response to tumor cell", "Positive regulation of t cell mediated immunity", "Positive regulation of t cell migration", "Positive regulation of t cell proliferation", "Positive regulation of t cell receptor signaling pathway", "Positive regulation of t cell tolerance induction", "Positive regulation of t helper 1 cell differentiation", "Positive regulation of t helper cell differentiation", "Positive regulation of tau protein kinase activity", "Positive regulation of telomerase activity", "Positive regulation of telomerase rna localization to cajal body", "Positive regulation of telomere capping", "Positive regulation of telomere maintenance", "Positive regulation of telomere maintenance via telomere lengthening", "Positive regulation of tissue remodeling", "Positive regulation of tolerance induction", "Positive regulation of toll like receptor 3 signaling pathway", "Positive regulation of toll like receptor 9 signaling pathway", "Positive regulation of toll like receptor signaling pathway", "Positive regulation of tor signaling", "Positive regulation of torc1 signaling", "Positive regulation of transcription by rna polymerase i", "Positive regulation of transcription by rna polymerase ii", "Positive regulation of transcription by rna polymerase iii", "Positive regulation of transcription elongation from rna polymerase ii promoter", "Positive regulation of transcription from rna polymerase ii promoter in response to endoplasmic reticulum stress", "Positive regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Positive regulation of transcription from rna polymerase ii promoter in response to stress", "Positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus", "Positive regulation of transcription of notch receptor target", "Positive regulation of transcription of nucleolar large rrna by rna polymerase i", "Positive regulation of transcription regulatory region dna binding", "Positive regulation of transferase activity", "Positive regulation of translation", "Positive regulation of translation in response to endoplasmic reticulum stress", "Positive regulation of translation in response to stress", "Positive regulation of translational initiation", "Positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Positive regulation of transmembrane transport", "Positive regulation of transmission of nerve impulse", "Positive regulation of transport", "Positive regulation of transporter activity", "Positive regulation of triglyceride biosynthetic process", "Positive regulation of triglyceride metabolic process", "Positive regulation of trophoblast cell migration", "Positive regulation of tumor necrosis factor mediated signaling pathway", "Positive regulation of tumor necrosis factor superfamily cytokine production", "Positive regulation of type i interferon mediated signaling pathway", "Positive regulation of type i interferon production", "Positive regulation of tyrosine phosphorylation of stat protein", "Positive regulation of ubiquitin dependent protein catabolic process", "Positive regulation of ubiquitin protein ligase activity", "Positive regulation of ubiquitin protein transferase activity", "Positive regulation of unsaturated fatty acid biosynthetic process", "Positive regulation of urine volume", "Positive regulation of vacuole organization", "Positive regulation of vascular associated smooth muscle cell apoptotic process", "Positive regulation of vascular associated smooth muscle cell differentiation", "Positive regulation of vascular associated smooth muscle cell migration", "Positive regulation of vascular associated smooth muscle cell proliferation", "Positive regulation of vascular endothelial cell proliferation", "Positive regulation of vascular endothelial growth factor production", "Positive regulation of vascular endothelial growth factor signaling pathway", "Positive regulation of vascular permeability", "Positive regulation of vasculature development", "Positive regulation of vasculogenesis", "Positive regulation of vasoconstriction", "Positive regulation of vesicle fusion", "Positive regulation of viral genome replication", "Positive regulation of viral life cycle", "Positive regulation of viral process", "Positive regulation of vitamin d receptor signaling pathway", "Positive regulation of voltage gated calcium channel activity", "Positive regulation of wnt signaling pathway", "Positive regulation of wound healing", "Positive regulation of wound healing spreading of epidermal cells", "Positive t cell selection", "Post anal tail morphogenesis", "Post chaperonin tubulin folding pathway", "Post embryonic development", "Post golgi vesicle mediated transport", "Post translational protein modification", "Postreplication repair", "Postsynapse organization", "Postsynapse to nucleus signaling pathway", "Postsynaptic actin cytoskeleton organization", "Postsynaptic cytoskeleton organization", "Postsynaptic membrane organization", "Postsynaptic modulation of chemical synaptic transmission", "Postsynaptic neurotransmitter receptor internalization", "Postsynaptic signal transduction", "Postsynaptic specialization organization", "Posttranscriptional regulation of gene expression", "Posttranslational protein targeting to endoplasmic reticulum membrane", "Posttranslational protein targeting to membrane translocation", "Potassium ion homeostasis", "Potassium ion import across plasma membrane", "Potassium ion transport", "Pre mirna processing", "Prenylation", "Presynapse organization", "Presynaptic active zone organization", "Presynaptic endocytosis", "Presynaptic modulation of chemical synaptic transmission", "Prevention of polyspermy", "Primary alcohol biosynthetic process", "Primary alcohol catabolic process", "Primary alcohol metabolic process", "Primary amino compound biosynthetic process", "Primary amino compound metabolic process", "Primary mirna processing", "Pro b cell differentiation", "Process utilizing autophagic mechanism", "Production of molecular mediator involved in inflammatory response", "Production of molecular mediator of immune response", "Production of sirna involved in rna interference", "Progesterone biosynthetic process", "Progesterone metabolic process", "Progesterone receptor signaling pathway", "Programmed cell death", "Programmed cell death in response to reactive oxygen species", "Programmed cell death involved in cell development", "Programmed necrotic cell death", "Prolactin secretion", "Proline metabolic process", "Proline transport", "Pronephros development", "Proprioception", "Prostaglandin transport", "Prostanoid biosynthetic process", "Prostanoid metabolic process", "Prostate gland development", "Prostate gland growth", "Proteasomal protein catabolic process", "Proteasome assembly", "Proteasome mediated ubiquitin dependent protein catabolic process", "Protection from natural killer cell mediated cytotoxicity", "Protection from non homologous end joining at telomere", "Protein acetylation", "Protein activation cascade", "Protein acylation", "Protein adp ribosylation", "Protein auto adp ribosylation", "Protein autophosphorylation", "Protein autoprocessing", "Protein autoubiquitination", "Protein catabolic process", "Protein catabolic process in the vacuole", "Protein complex oligomerization", "Protein containing complex disassembly", "Protein containing complex localization", "Protein containing complex organization", "Protein containing complex remodeling", "Protein de adp ribosylation", "Protein deglycosylation", "Protein demannosylation", "Protein demethylation", "Protein deneddylation", "Protein depalmitoylation", "Protein dephosphorylation", "Protein depolymerization", "Protein destabilization", "Protein desumoylation", "Protein deubiquitination involved in ubiquitin dependent protein catabolic process", "Protein dna complex assembly", "Protein dna complex disassembly", "Protein dna complex subunit organization", "Protein dna covalent cross linking repair", "Protein exit from endoplasmic reticulum", "Protein export from nucleus", "Protein folding", "Protein folding in endoplasmic reticulum", "Protein geranylgeranylation", "Protein heterooligomerization", "Protein heterotetramerization", "Protein hexamerization", "Protein homooligomerization", "Protein homotetramerization", "Protein hydroxylation", "Protein import", "Protein import into mitochondrial matrix", "Protein import into peroxisome matrix", "Protein insertion into er membrane", "Protein insertion into er membrane by stop transfer membrane anchor sequence", "Protein insertion into membrane", "Protein insertion into mitochondrial inner membrane", "Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway", "Protein k11 linked ubiquitination", "Protein k27 linked ubiquitination", "Protein k29 linked ubiquitination", "Protein k48 linked deubiquitination", "Protein k48 linked ubiquitination", "Protein k6 linked ubiquitination", "Protein k63 linked deubiquitination", "Protein k63 linked ubiquitination", "Protein kinase a signaling", "Protein kinase b signaling", "Protein kinase c signaling", "Protein lipid complex assembly", "Protein lipid complex subunit organization", "Protein localization to adherens junction", "Protein localization to axon", "Protein localization to basolateral plasma membrane", "Protein localization to cell cell junction", "Protein localization to cell cortex", "Protein localization to cell junction", "Protein localization to cell periphery", "Protein localization to cell surface", "Protein localization to chromatin", "Protein localization to chromosome", "Protein localization to chromosome centromeric region", "Protein localization to chromosome telomeric region", "Protein localization to ciliary membrane", "Protein localization to cilium", "Protein localization to condensed chromosome", "Protein localization to cytoplasmic stress granule", "Protein localization to cytoskeleton", "Protein localization to early endosome", "Protein localization to endoplasmic reticulum", "Protein localization to endoplasmic reticulum exit site", "Protein localization to endosome", "Protein localization to extracellular region", "Protein localization to golgi apparatus", "Protein localization to lysosome", "Protein localization to membrane raft", "Protein localization to microtubule", "Protein localization to microtubule end", "Protein localization to microtubule organizing center", "Protein localization to mitochondrion", "Protein localization to non motile cilium", "Protein localization to nuclear body", "Protein localization to nuclear envelope", "Protein localization to nucleolus", "Protein localization to nucleoplasm", "Protein localization to nucleus", "Protein localization to organelle", "Protein localization to perinuclear region of cytoplasm", "Protein localization to phagophore assembly site", "Protein localization to plasma membrane", "Protein localization to postsynapse", "Protein localization to presynapse", "Protein localization to synapse", "Protein localization to vacuole", "Protein mannosylation", "Protein maturation", "Protein maturation by 4fe 4s cluster transfer", "Protein maturation by iron sulfur cluster transfer", "Protein maturation by protein folding", "Protein methylation", "Protein modification by small protein conjugation", "Protein modification by small protein conjugation or removal", "Protein modification by small protein removal", "Protein monoubiquitination", "Protein n linked glycosylation", "Protein neddylation", "Protein nitrosylation", "Protein o linked glycosylation", "Protein o linked glycosylation via serine", "Protein o linked glycosylation via threonine", "Protein o linked mannosylation", "Protein oxidation", "Protein palmitoylation", "Protein peptidyl prolyl isomerization", "Protein poly adp ribosylation", "Protein polyglutamylation", "Protein polymerization", "Protein polyubiquitination", "Protein polyufmylation", "Protein processing", "Protein processing involved in protein targeting to mitochondrion", "Protein quality control for misfolded or incompletely synthesized proteins", "Protein refolding", "Protein repair", "Protein retention in er lumen", "Protein retention in golgi apparatus", "Protein stabilization", "Protein sumoylation", "Protein targeting", "Protein targeting to lysosome", "Protein targeting to membrane", "Protein targeting to mitochondrion", "Protein targeting to peroxisome", "Protein targeting to vacuole", "Protein tetramerization", "Protein transmembrane import into intracellular organelle", "Protein transmembrane transport", "Protein transport along microtubule", "Protein transport within lipid bilayer", "Protein trimerization", "Protein ufmylation", "Proteoglycan biosynthetic process", "Proteoglycan metabolic process", "Proteolysis", "Proton transmembrane transport", "Protoporphyrinogen ix biosynthetic process", "Protoporphyrinogen ix metabolic process", "Proximal distal pattern formation", "Proximal tubule development", "Pseudopodium organization", "Pseudouridine synthesis", "Pteridine containing compound biosynthetic process", "Pteridine containing compound metabolic process", "Pulmonary artery morphogenesis", "Pulmonary valve development", "Pulmonary valve morphogenesis", "Purine containing compound biosynthetic process", "Purine containing compound catabolic process", "Purine containing compound metabolic process", "Purine containing compound salvage", "Purine containing compound transmembrane transport", "Purine deoxyribonucleoside metabolic process", "Purine deoxyribonucleoside monophosphate catabolic process", "Purine deoxyribonucleoside monophosphate metabolic process", "Purine deoxyribonucleoside triphosphate metabolic process", "Purine deoxyribonucleotide biosynthetic process", "Purine deoxyribonucleotide catabolic process", "Purine deoxyribonucleotide metabolic process", "Purine nucleobase biosynthetic process", "Purine nucleobase metabolic process", "Purine nucleoside biosynthetic process", "Purine nucleoside catabolic process", "Purine nucleoside diphosphate biosynthetic process", "Purine nucleoside diphosphate catabolic process", "Purine nucleoside metabolic process", "Purine nucleoside monophosphate biosynthetic process", "Purine nucleoside monophosphate catabolic process", "Purine nucleoside monophosphate metabolic process", "Purine nucleoside triphosphate catabolic process", "Purine nucleotide catabolic process", "Purine nucleotide salvage", "Purine nucleotide transport", "Purine ribonucleoside catabolic process", "Purine ribonucleoside metabolic process", "Purine ribonucleoside salvage", "Purine ribonucleotide salvage", "Purinergic nucleotide receptor signaling pathway", "Pyramidal neuron development", "Pyramidal neuron differentiation", "Pyridine containing compound biosynthetic process", "Pyridine containing compound catabolic process", "Pyridine containing compound metabolic process", "Pyridine nucleotide biosynthetic process", "Pyridine nucleotide metabolic process", "Pyrimidine containing compound biosynthetic process", "Pyrimidine containing compound catabolic process", "Pyrimidine containing compound metabolic process", "Pyrimidine containing compound transmembrane transport", "Pyrimidine deoxyribonucleoside metabolic process", "Pyrimidine deoxyribonucleoside monophosphate biosynthetic process", "Pyrimidine deoxyribonucleoside monophosphate metabolic process", "Pyrimidine deoxyribonucleoside triphosphate metabolic process", "Pyrimidine deoxyribonucleotide biosynthetic process", "Pyrimidine deoxyribonucleotide metabolic process", "Pyrimidine nucleobase biosynthetic process", "Pyrimidine nucleobase catabolic process", "Pyrimidine nucleobase metabolic process", "Pyrimidine nucleoside diphosphate biosynthetic process", "Pyrimidine nucleoside diphosphate metabolic process", "Pyrimidine nucleoside metabolic process", "Pyrimidine nucleoside monophosphate biosynthetic process", "Pyrimidine nucleoside monophosphate metabolic process", "Pyrimidine nucleoside triphosphate biosynthetic process", "Pyrimidine nucleoside triphosphate metabolic process", "Pyrimidine nucleotide catabolic process", "Pyrimidine nucleotide metabolic process", "Pyrimidine ribonucleoside diphosphate metabolic process", "Pyrimidine ribonucleoside monophosphate metabolic process", "Pyrimidine ribonucleoside triphosphate biosynthetic process", "Pyrimidine ribonucleoside triphosphate metabolic process", "Pyrimidine ribonucleotide biosynthetic process", "Pyrimidine ribonucleotide metabolic process", "Pyroptosis", "Pyruvate metabolic process", "Quaternary ammonium group transport", "Quinone metabolic process", "R loop disassembly", "Rab protein signal transduction", "Rac protein signal transduction", "Radial glial cell differentiation", "Rap protein signal transduction", "Ras protein signal transduction", "Reactive nitrogen species metabolic process", "Reactive oxygen species biosynthetic process", "Reactive oxygen species metabolic process", "Receptor catabolic process", "Receptor clustering", "Receptor diffusion trapping", "Receptor internalization", "Receptor localization to synapse", "Receptor mediated endocytosis", "Receptor mediated endocytosis involved in cholesterol transport", "Receptor metabolic process", "Receptor recycling", "Receptor signaling pathway via stat", "Receptor transactivation", "Recognition of apoptotic cell", "Recombinational repair", "Reelin mediated signaling pathway", "Reflex", "Regeneration", "Regionalization", "Regulated exocytosis", "Regulation by virus of viral protein levels in host cell", "Regulation of 3 utr mediated mrna stabilization", "Regulation of actin cytoskeleton reorganization", "Regulation of actin filament based movement", "Regulation of actin filament based process", "Regulation of actin filament bundle assembly", "Regulation of actin filament length", "Regulation of actin filament organization", "Regulation of actin nucleation", "Regulation of action potential", "Regulation of activin receptor signaling pathway", "Regulation of actomyosin structure organization", "Regulation of acute inflammatory response", "Regulation of acute inflammatory response to antigenic stimulus", "Regulation of acyl coa biosynthetic process", "Regulation of adaptive immune response", "Regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Regulation of adenylate cyclase activity", "Regulation of adherens junction organization", "Regulation of aerobic respiration", "Regulation of alcohol biosynthetic process", "Regulation of alpha beta t cell activation", "Regulation of alpha beta t cell differentiation", "Regulation of alternative mrna splicing via spliceosome", "Regulation of amino acid transmembrane transport", "Regulation of amino acid transport", "Regulation of amyloid beta clearance", "Regulation of amyloid fibril formation", "Regulation of amyloid precursor protein catabolic process", "Regulation of anaphase promoting complex dependent catabolic process", "Regulation of anatomical structure morphogenesis", "Regulation of anatomical structure size", "Regulation of androgen receptor signaling pathway", "Regulation of animal organ formation", "Regulation of animal organ morphogenesis", "Regulation of anion channel activity", "Regulation of anion transmembrane transport", "Regulation of anion transport", "Regulation of anoikis", "Regulation of antigen receptor mediated signaling pathway", "Regulation of apoptotic cell clearance", "Regulation of apoptotic dna fragmentation", "Regulation of apoptotic process involved in development", "Regulation of apoptotic signaling pathway", "Regulation of appetite", "Regulation of arachidonic acid secretion", "Regulation of arp2 3 complex mediated actin nucleation", "Regulation of aspartic type endopeptidase activity involved in amyloid precursor protein catabolic process", "Regulation of aspartic type peptidase activity", "Regulation of astrocyte differentiation", "Regulation of atp biosynthetic process", "Regulation of atp dependent activity", "Regulation of atp metabolic process", "Regulation of atrial cardiac muscle cell membrane repolarization", "Regulation of attachment of spindle microtubules to kinetochore", "Regulation of autophagosome maturation", "Regulation of autophagy", "Regulation of autophagy of mitochondrion", "Regulation of autophagy of mitochondrion in response to mitochondrial depolarization", "Regulation of axon diameter", "Regulation of axon guidance", "Regulation of axonogenesis", "Regulation of b cell activation", "Regulation of b cell apoptotic process", "Regulation of b cell differentiation", "Regulation of b cell mediated immunity", "Regulation of b cell proliferation", "Regulation of barbed end actin filament capping", "Regulation of behavior", "Regulation of bicellular tight junction assembly", "Regulation of binding", "Regulation of biological process involved in symbiotic interaction", "Regulation of biomineralization", "Regulation of blood brain barrier permeability", "Regulation of blood circulation", "Regulation of blood pressure", "Regulation of bmp signaling pathway", "Regulation of body fluid levels", "Regulation of bone mineralization", "Regulation of bone remodeling", "Regulation of bone resorption", "Regulation of branching involved in lung morphogenesis", "Regulation of branching morphogenesis of a nerve", "Regulation of brown fat cell differentiation", "Regulation of calcineurin mediated signaling", "Regulation of calcium ion dependent exocytosis", "Regulation of calcium ion export across plasma membrane", "Regulation of calcium ion import", "Regulation of calcium ion transmembrane transport", "Regulation of calcium ion transmembrane transporter activity", "Regulation of calcium ion transport", "Regulation of calcium ion transport into cytosol", "Regulation of calcium mediated signaling", "Regulation of camp dependent protein kinase activity", "Regulation of camp mediated signaling", "Regulation of canonical wnt signaling pathway", "Regulation of carbohydrate biosynthetic process", "Regulation of carbohydrate catabolic process", "Regulation of carbohydrate metabolic process", "Regulation of cardiac conduction", "Regulation of cardiac muscle adaptation", "Regulation of cardiac muscle cell action potential", "Regulation of cardiac muscle cell action potential involved in regulation of contraction", "Regulation of cardiac muscle cell membrane potential", "Regulation of cardiac muscle cell membrane repolarization", "Regulation of cardiac muscle cell proliferation", "Regulation of cardiac muscle contraction", "Regulation of cardiac muscle contraction by calcium ion signaling", "Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion", "Regulation of cardioblast differentiation", "Regulation of cardiocyte differentiation", "Regulation of cartilage development", "Regulation of catabolic process", "Regulation of catecholamine metabolic process", "Regulation of cation channel activity", "Regulation of cation transmembrane transport", "Regulation of caveolin mediated endocytosis", "Regulation of cd4 positive alpha beta t cell activation", "Regulation of cd4 positive alpha beta t cell differentiation", "Regulation of cd8 positive alpha beta t cell activation", "Regulation of cell activation", "Regulation of cell adhesion", "Regulation of cell adhesion mediated by integrin", "Regulation of cell aging", "Regulation of cell cell adhesion", "Regulation of cell cell adhesion mediated by cadherin", "Regulation of cell communication by electrical coupling", "Regulation of cell communication by electrical coupling involved in cardiac conduction", "Regulation of cell cycle", "Regulation of cell cycle checkpoint", "Regulation of cell cycle g1 s phase transition", "Regulation of cell cycle g2 m phase transition", "Regulation of cell cycle phase transition", "Regulation of cell cycle process", "Regulation of cell death", "Regulation of cell development", "Regulation of cell differentiation", "Regulation of cell division", "Regulation of cell growth involved in cardiac muscle cell development", "Regulation of cell junction assembly", "Regulation of cell killing", "Regulation of cell matrix adhesion", "Regulation of cell maturation", "Regulation of cell migration involved in sprouting angiogenesis", "Regulation of cell morphogenesis", "Regulation of cell morphogenesis involved in differentiation", "Regulation of cell population proliferation", "Regulation of cell projection assembly", "Regulation of cell projection organization", "Regulation of cell projection size", "Regulation of cell shape", "Regulation of cell size", "Regulation of cell substrate adhesion", "Regulation of cell substrate junction organization", "Regulation of cellular amide metabolic process", "Regulation of cellular amine metabolic process", "Regulation of cellular amino acid metabolic process", "Regulation of cellular carbohydrate catabolic process", "Regulation of cellular carbohydrate metabolic process", "Regulation of cellular component biogenesis", "Regulation of cellular component movement", "Regulation of cellular component size", "Regulation of cellular ketone metabolic process", "Regulation of cellular localization", "Regulation of cellular macromolecule biosynthetic process", "Regulation of cellular ph", "Regulation of cellular protein catabolic process", "Regulation of cellular respiration", "Regulation of cellular response to growth factor stimulus", "Regulation of cellular response to heat", "Regulation of cellular response to hypoxia", "Regulation of cellular response to insulin stimulus", "Regulation of cellular response to osmotic stress", "Regulation of cellular response to stress", "Regulation of cellular response to transforming growth factor beta stimulus", "Regulation of cellular response to vascular endothelial growth factor stimulus", "Regulation of centriole replication", "Regulation of centrosome cycle", "Regulation of chaperone mediated autophagy", "Regulation of chemokine mediated signaling pathway", "Regulation of chemotaxis", "Regulation of chloride transport", "Regulation of cholesterol biosynthetic process", "Regulation of cholesterol efflux", "Regulation of cholesterol esterification", "Regulation of cholesterol metabolic process", "Regulation of chondrocyte differentiation", "Regulation of chromatin assembly", "Regulation of chromatin assembly or disassembly", "Regulation of chromatin binding", "Regulation of chromatin organization", "Regulation of chromosome condensation", "Regulation of chromosome organization", "Regulation of chromosome segregation", "Regulation of chromosome separation", "Regulation of cilium assembly", "Regulation of cilium beat frequency", "Regulation of cilium beat frequency involved in ciliary motility", "Regulation of cilium dependent cell motility", "Regulation of cilium movement", "Regulation of circadian rhythm", "Regulation of clathrin dependent endocytosis", "Regulation of coagulation", "Regulation of collagen fibril organization", "Regulation of collagen metabolic process", "Regulation of collateral sprouting", "Regulation of complement activation", "Regulation of complement dependent cytotoxicity", "Regulation of connective tissue replacement", "Regulation of core promoter binding", "Regulation of cyclase activity", "Regulation of cyclic nucleotide phosphodiesterase activity", "Regulation of cyclin dependent protein kinase activity", "Regulation of cysteine type endopeptidase activity", "Regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis", "Regulation of cytokinesis", "Regulation of cytoplasmic mrna processing body assembly", "Regulation of cytoplasmic translation", "Regulation of cytoplasmic translational elongation", "Regulation of cytoplasmic translational initiation", "Regulation of cytoplasmic transport", "Regulation of cytoskeleton organization", "Regulation of cytosolic calcium ion concentration", "Regulation of deacetylase activity", "Regulation of defense response", "Regulation of defense response to bacterium", "Regulation of defense response to virus", "Regulation of defense response to virus by host", "Regulation of delayed rectifier potassium channel activity", "Regulation of dendrite development", "Regulation of dendrite extension", "Regulation of dendrite morphogenesis", "Regulation of dendritic cell chemotaxis", "Regulation of dendritic cell differentiation", "Regulation of dendritic spine development", "Regulation of dendritic spine maintenance", "Regulation of dendritic spine morphogenesis", "Regulation of deoxyribonuclease activity", "Regulation of dephosphorylation", "Regulation of developmental growth", "Regulation of digestive system process", "Regulation of dna binding", "Regulation of dna binding transcription factor activity", "Regulation of dna biosynthetic process", "Regulation of dna catabolic process", "Regulation of dna damage checkpoint", "Regulation of dna damage response signal transduction by p53 class mediator", "Regulation of dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator", "Regulation of dna demethylation", "Regulation of dna dependent dna replication", "Regulation of dna dependent dna replication initiation", "Regulation of dna directed dna polymerase activity", "Regulation of dna duplex unwinding", "Regulation of dna helicase activity", "Regulation of dna ligation", "Regulation of dna metabolic process", "Regulation of dna methylation", "Regulation of dna methylation dependent heterochromatin assembly", "Regulation of dna primase activity", "Regulation of dna recombination", "Regulation of dna repair", "Regulation of dna replication", "Regulation of dna strand elongation", "Regulation of dna templated transcription elongation", "Regulation of dna templated transcription in response to stress", "Regulation of dna templated transcription initiation", "Regulation of dna topoisomerase atp hydrolyzing activity", "Regulation of dopamine receptor signaling pathway", "Regulation of dopaminergic neuron differentiation", "Regulation of double strand break repair", "Regulation of double strand break repair via homologous recombination", "Regulation of double strand break repair via nonhomologous end joining", "Regulation of early endosome to late endosome transport", "Regulation of eating behavior", "Regulation of electron transfer activity", "Regulation of embryonic development", "Regulation of endocytic recycling", "Regulation of endocytosis", "Regulation of endodeoxyribonuclease activity", "Regulation of endodermal cell differentiation", "Regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Regulation of endoplasmic reticulum tubular network organization", "Regulation of endoplasmic reticulum unfolded protein response", "Regulation of endosome to plasma membrane protein transport", "Regulation of endothelial cell chemotaxis", "Regulation of endothelial cell development", "Regulation of endothelial cell differentiation", "Regulation of endothelial cell migration", "Regulation of entry of bacterium into host cell", "Regulation of epidermal growth factor activated receptor activity", "Regulation of epidermis development", "Regulation of epithelial cell apoptotic process", "Regulation of epithelial cell differentiation", "Regulation of epithelial cell differentiation involved in kidney development", "Regulation of epithelial cell migration", "Regulation of epithelial cell proliferation involved in lung morphogenesis", "Regulation of epithelial to mesenchymal transition", "Regulation of er associated ubiquitin dependent protein catabolic process", "Regulation of er to golgi vesicle mediated transport", "Regulation of erad pathway", "Regulation of erbb signaling pathway", "Regulation of erythrocyte differentiation", "Regulation of establishment of planar polarity", "Regulation of establishment of protein localization", "Regulation of establishment of protein localization to chromosome", "Regulation of establishment of protein localization to mitochondrion", "Regulation of establishment or maintenance of cell polarity", "Regulation of excretion", "Regulation of execution phase of apoptosis", "Regulation of exit from mitosis", "Regulation of exocytosis", "Regulation of exosomal secretion", "Regulation of extent of cell growth", "Regulation of extracellular matrix assembly", "Regulation of extracellular matrix disassembly", "Regulation of extracellular matrix organization", "Regulation of extrinsic apoptotic signaling pathway", "Regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Regulation of fat cell differentiation", "Regulation of fat cell proliferation", "Regulation of fatty acid beta oxidation", "Regulation of fatty acid biosynthetic process", "Regulation of fatty acid metabolic process", "Regulation of fatty acid oxidation", "Regulation of fatty acid transport", "Regulation of fc gamma receptor signaling pathway involved in phagocytosis", "Regulation of fc receptor mediated stimulatory signaling pathway", "Regulation of feeding behavior", "Regulation of fertilization", "Regulation of fibroblast growth factor receptor signaling pathway", "Regulation of fibroblast migration", "Regulation of filopodium assembly", "Regulation of focal adhesion disassembly", "Regulation of g protein coupled receptor signaling pathway", "Regulation of g0 to g1 transition", "Regulation of gastrulation", "Regulation of gene expression by genomic imprinting", "Regulation of gene expression epigenetic", "Regulation of gene silencing by rna", "Regulation of generation of precursor metabolites and energy", "Regulation of genetic imprinting", "Regulation of germ cell proliferation", "Regulation of glial cell apoptotic process", "Regulation of glial cell differentiation", "Regulation of glial cell migration", "Regulation of glial cell proliferation", "Regulation of gliogenesis", "Regulation of glucagon secretion", "Regulation of glucan biosynthetic process", "Regulation of glucocorticoid biosynthetic process", "Regulation of glucocorticoid metabolic process", "Regulation of glucocorticoid receptor signaling pathway", "Regulation of gluconeogenesis", "Regulation of glucose import", "Regulation of glucose metabolic process", "Regulation of glucose transmembrane transport", "Regulation of glucosylceramidase activity", "Regulation of glutamate receptor clustering", "Regulation of glutamate secretion", "Regulation of glutamine family amino acid metabolic process", "Regulation of glycogen catabolic process", "Regulation of glycogen metabolic process", "Regulation of glycogen starch synthase activity", "Regulation of glycolytic process", "Regulation of glycoprotein metabolic process", "Regulation of golgi organization", "Regulation of golgi to plasma membrane protein transport", "Regulation of gonad development", "Regulation of granulocyte chemotaxis", "Regulation of granulocyte differentiation", "Regulation of growth", "Regulation of gtp binding", "Regulation of gtpase activity", "Regulation of guanyl nucleotide exchange factor activity", "Regulation of hair cycle", "Regulation of hair follicle development", "Regulation of heart contraction", "Regulation of heart growth", "Regulation of heart rate", "Regulation of heart rate by cardiac conduction", "Regulation of heart rate by chemical signal", "Regulation of helicase activity", "Regulation of hematopoietic progenitor cell differentiation", "Regulation of hematopoietic stem cell differentiation", "Regulation of hematopoietic stem cell proliferation", "Regulation of hemoglobin biosynthetic process", "Regulation of hemopoiesis", "Regulation of hepatic stellate cell activation", "Regulation of heterotypic cell cell adhesion", "Regulation of hexokinase activity", "Regulation of high voltage gated calcium channel activity", "Regulation of hippo signaling", "Regulation of histamine secretion by mast cell", "Regulation of histone deacetylase activity", "Regulation of histone deacetylation", "Regulation of histone h2b ubiquitination", "Regulation of histone h3 k14 acetylation", "Regulation of histone h3 k27 methylation", "Regulation of histone h3 k4 methylation", "Regulation of histone h3 k9 methylation", "Regulation of histone h3 k9 trimethylation", "Regulation of histone h4 acetylation", "Regulation of histone h4 k16 acetylation", "Regulation of histone methylation", "Regulation of histone modification", "Regulation of histone phosphorylation", "Regulation of histone ubiquitination", "Regulation of homotypic cell cell adhesion", "Regulation of hormone biosynthetic process", "Regulation of hormone levels", "Regulation of hormone metabolic process", "Regulation of hormone secretion", "Regulation of humoral immune response", "Regulation of hyaluronan biosynthetic process", "Regulation of hydrogen peroxide biosynthetic process", "Regulation of hydrogen peroxide mediated programmed cell death", "Regulation of hydrogen peroxide metabolic process", "Regulation of hydrolase activity", "Regulation of i kappab phosphorylation", "Regulation of icosanoid secretion", "Regulation of immune effector process", "Regulation of immune response", "Regulation of immune system process", "Regulation of immunoglobulin production", "Regulation of inclusion body assembly", "Regulation of inflammatory response", "Regulation of inflammatory response to antigenic stimulus", "Regulation of innate immune response", "Regulation of inositol 1 4 5 trisphosphate sensitive calcium release channel activity", "Regulation of insulin like growth factor receptor signaling pathway", "Regulation of insulin receptor signaling pathway", "Regulation of insulin secretion", "Regulation of insulin secretion involved in cellular response to glucose stimulus", "Regulation of integrin activation", "Regulation of integrin mediated signaling pathway", "Regulation of interleukin 1 mediated signaling pathway", "Regulation of interleukin 6 mediated signaling pathway", "Regulation of intestinal absorption", "Regulation of intracellular estrogen receptor signaling pathway", "Regulation of intracellular lipid transport", "Regulation of intracellular protein transport", "Regulation of intracellular signal transduction", "Regulation of intracellular steroid hormone receptor signaling pathway", "Regulation of intracellular transport", "Regulation of intrinsic apoptotic signaling pathway", "Regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Regulation of inward rectifier potassium channel activity", "Regulation of ion transmembrane transport", "Regulation of ion transport", "Regulation of ire1 mediated unfolded protein response", "Regulation of isomerase activity", "Regulation of isotype switching", "Regulation of jnk cascade", "Regulation of jun kinase activity", "Regulation of keratinocyte differentiation", "Regulation of keratinocyte migration", "Regulation of keratinocyte proliferation", "Regulation of kidney development", "Regulation of l glutamate import across plasma membrane", "Regulation of lamellipodium assembly", "Regulation of lamellipodium morphogenesis", "Regulation of lamellipodium organization", "Regulation of leukocyte adhesion to vascular endothelial cell", "Regulation of leukocyte apoptotic process", "Regulation of leukocyte chemotaxis", "Regulation of leukocyte degranulation", "Regulation of leukocyte differentiation", "Regulation of leukocyte mediated cytotoxicity", "Regulation of leukocyte mediated immunity", "Regulation of leukocyte migration", "Regulation of leukocyte proliferation", "Regulation of ligase activity", "Regulation of lipase activity", "Regulation of lipid biosynthetic process", "Regulation of lipid catabolic process", "Regulation of lipid kinase activity", "Regulation of lipid localization", "Regulation of lipid metabolic process", "Regulation of lipid storage", "Regulation of lipid transport", "Regulation of lipophagy", "Regulation of lipopolysaccharide mediated signaling pathway", "Regulation of lipoprotein lipase activity", "Regulation of lipoprotein metabolic process", "Regulation of lipoprotein particle clearance", "Regulation of locomotion involved in locomotory behavior", "Regulation of long chain fatty acid import across plasma membrane", "Regulation of long chain fatty acid import into cell", "Regulation of long term neuronal synaptic plasticity", "Regulation of long term synaptic depression", "Regulation of long term synaptic potentiation", "Regulation of low density lipoprotein particle clearance", "Regulation of lyase activity", "Regulation of lymphangiogenesis", "Regulation of lymphocyte activation", "Regulation of lymphocyte apoptotic process", "Regulation of lymphocyte chemotaxis", "Regulation of lymphocyte differentiation", "Regulation of lymphocyte mediated immunity", "Regulation of lymphocyte migration", "Regulation of lymphoid progenitor cell differentiation", "Regulation of lysosomal lumen ph", "Regulation of lysosomal protein catabolic process", "Regulation of lysosome organization", "Regulation of macroautophagy", "Regulation of macrophage activation", "Regulation of macrophage apoptotic process", "Regulation of macrophage chemotaxis", "Regulation of macrophage differentiation", "Regulation of macrophage migration", "Regulation of maintenance of sister chromatid cohesion", "Regulation of male gonad development", "Regulation of mammary gland epithelial cell proliferation", "Regulation of map kinase activity", "Regulation of mast cell activation", "Regulation of mast cell activation involved in immune response", "Regulation of matrix metallopeptidase secretion", "Regulation of mda 5 signaling pathway", "Regulation of megakaryocyte differentiation", "Regulation of meiotic cell cycle", "Regulation of meiotic cell cycle phase transition", "Regulation of meiotic nuclear division", "Regulation of membrane depolarization", "Regulation of membrane depolarization during action potential", "Regulation of membrane depolarization during cardiac muscle cell action potential", "Regulation of membrane invagination", "Regulation of membrane lipid distribution", "Regulation of membrane permeability", "Regulation of membrane potential", "Regulation of membrane protein ectodomain proteolysis", "Regulation of membrane repolarization", "Regulation of membrane repolarization during action potential", "Regulation of membrane repolarization during cardiac muscle cell action potential", "Regulation of membrane tubulation", "Regulation of mesenchymal cell proliferation", "Regulation of mesenchymal stem cell differentiation", "Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis", "Regulation of mesoderm development", "Regulation of metal ion transport", "Regulation of metalloendopeptidase activity", "Regulation of metallopeptidase activity", "Regulation of metanephros development", "Regulation of metaphase plate congression", "Regulation of microtubule based movement", "Regulation of microtubule based process", "Regulation of microtubule binding", "Regulation of microtubule cytoskeleton organization", "Regulation of microtubule depolymerization", "Regulation of microtubule nucleation", "Regulation of microtubule polymerization", "Regulation of microtubule polymerization or depolymerization", "Regulation of microvillus assembly", "Regulation of microvillus length", "Regulation of microvillus organization", "Regulation of mirna catabolic process", "Regulation of mirna metabolic process", "Regulation of mirna transcription", "Regulation of mitochondrial atp synthesis coupled electron transport", "Regulation of mitochondrial dna replication", "Regulation of mitochondrial electron transport nadh to ubiquinone", "Regulation of mitochondrial fission", "Regulation of mitochondrial fusion", "Regulation of mitochondrial gene expression", "Regulation of mitochondrial membrane permeability", "Regulation of mitochondrial membrane permeability involved in apoptotic process", "Regulation of mitochondrial membrane potential", "Regulation of mitochondrial mrna stability", "Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Regulation of mitochondrial rna catabolic process", "Regulation of mitochondrion organization", "Regulation of mitophagy", "Regulation of mitotic cell cycle", "Regulation of mitotic cell cycle phase transition", "Regulation of mitotic cell cycle spindle assembly checkpoint", "Regulation of mitotic centrosome separation", "Regulation of mitotic cytokinesis", "Regulation of mitotic nuclear division", "Regulation of mitotic recombination", "Regulation of mitotic sister chromatid segregation", "Regulation of mitotic spindle assembly", "Regulation of modification of postsynaptic structure", "Regulation of modification of synaptic structure", "Regulation of monocyte chemotaxis", "Regulation of monocyte differentiation", "Regulation of mononuclear cell migration", "Regulation of monooxygenase activity", "Regulation of morphogenesis of a branching structure", "Regulation of morphogenesis of an epithelium", "Regulation of mrna 3 end processing", "Regulation of mrna binding", "Regulation of mrna catabolic process", "Regulation of mrna export from nucleus", "Regulation of mrna metabolic process", "Regulation of mrna polyadenylation", "Regulation of mrna processing", "Regulation of mrna splicing via spliceosome", "Regulation of multicellular organism growth", "Regulation of multicellular organismal development", "Regulation of muscle adaptation", "Regulation of muscle cell differentiation", "Regulation of muscle contraction", "Regulation of muscle hypertrophy", "Regulation of muscle organ development", "Regulation of muscle system process", "Regulation of myelination", "Regulation of myeloid cell apoptotic process", "Regulation of myeloid cell differentiation", "Regulation of myeloid leukocyte differentiation", "Regulation of myeloid leukocyte mediated immunity", "Regulation of myoblast differentiation", "Regulation of myoblast fusion", "Regulation of myosin light chain phosphatase activity", "Regulation of myotube differentiation", "Regulation of nad p h oxidase activity", "Regulation of nadp metabolic process", "Regulation of natural killer cell activation", "Regulation of natural killer cell mediated immune response to tumor cell", "Regulation of natural killer cell mediated immunity", "Regulation of necrotic cell death", "Regulation of nervous system development", "Regulation of nervous system process", "Regulation of neural precursor cell proliferation", "Regulation of neuroblast proliferation", "Regulation of neurogenesis", "Regulation of neuromuscular junction development", "Regulation of neuron differentiation", "Regulation of neuron migration", "Regulation of neuron projection arborization", "Regulation of neuron projection development", "Regulation of neuron projection regeneration", "Regulation of neuronal action potential", "Regulation of neuronal synaptic plasticity", "Regulation of neurotransmitter levels", "Regulation of neurotransmitter receptor activity", "Regulation of neurotransmitter transport", "Regulation of neurotransmitter uptake", "Regulation of neurotrophin trk receptor signaling pathway", "Regulation of neutrophil chemotaxis", "Regulation of neutrophil migration", "Regulation of nik nf kappab signaling", "Regulation of nitric oxide mediated signal transduction", "Regulation of nitric oxide metabolic process", "Regulation of nitric oxide synthase activity", "Regulation of nk t cell activation", "Regulation of nk t cell differentiation", "Regulation of nmda receptor activity", "Regulation of non motile cilium assembly", "Regulation of notch signaling pathway", "Regulation of nuclear cell cycle dna replication", "Regulation of nuclear division", "Regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Regulation of nuclear transcribed mrna poly a tail shortening", "Regulation of nuclease activity", "Regulation of nucleobase containing compound transport", "Regulation of nucleocytoplasmic transport", "Regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Regulation of nucleotide binding oligomerization domain containing signaling pathway", "Regulation of nucleotide biosynthetic process", "Regulation of nucleotide metabolic process", "Regulation of oligodendrocyte differentiation", "Regulation of oocyte maturation", "Regulation of organ growth", "Regulation of organelle assembly", "Regulation of organelle organization", "Regulation of organelle transport along microtubule", "Regulation of organic acid transport", "Regulation of ossification", "Regulation of osteoblast differentiation", "Regulation of osteoblast proliferation", "Regulation of osteoclast differentiation", "Regulation of oxidative phosphorylation", "Regulation of oxidative stress induced cell death", "Regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Regulation of oxidoreductase activity", "Regulation of p38mapk cascade", "Regulation of pattern recognition receptor signaling pathway", "Regulation of peptidase activity", "Regulation of peptide transport", "Regulation of peptidyl cysteine s nitrosylation", "Regulation of peptidyl lysine acetylation", "Regulation of peptidyl serine phosphorylation", "Regulation of peptidyl serine phosphorylation of stat protein", "Regulation of peptidyl threonine phosphorylation", "Regulation of peptidyl tyrosine phosphorylation", "Regulation of perk mediated unfolded protein response", "Regulation of ph", "Regulation of phagocytosis", "Regulation of phenotypic switching", "Regulation of phosphatase activity", "Regulation of phosphatidylcholine biosynthetic process", "Regulation of phosphatidylcholine metabolic process", "Regulation of phosphatidylinositol 3 kinase activity", "Regulation of phosphatidylinositol 3 kinase signaling", "Regulation of phospholipase a2 activity", "Regulation of phospholipase activity", "Regulation of phospholipase c activity", "Regulation of phospholipid biosynthetic process", "Regulation of phospholipid catabolic process", "Regulation of phospholipid metabolic process", "Regulation of phosphoprotein phosphatase activity", "Regulation of phosphorus metabolic process", "Regulation of pigmentation", "Regulation of pinocytosis", "Regulation of plasma lipoprotein particle levels", "Regulation of plasma membrane organization", "Regulation of plasminogen activation", "Regulation of platelet activation", "Regulation of platelet aggregation", "Regulation of platelet derived growth factor receptor signaling pathway", "Regulation of podosome assembly", "Regulation of polysaccharide metabolic process", "Regulation of positive chemotaxis", "Regulation of post translational protein modification", "Regulation of postsynapse organization", "Regulation of postsynaptic cytosolic calcium ion concentration", "Regulation of postsynaptic membrane neurotransmitter receptor levels", "Regulation of postsynaptic membrane potential", "Regulation of postsynaptic neurotransmitter receptor internalization", "Regulation of potassium ion import", "Regulation of potassium ion transmembrane transporter activity", "Regulation of potassium ion transport", "Regulation of presynapse organization", "Regulation of presynaptic cytosolic calcium ion concentration", "Regulation of pro b cell differentiation", "Regulation of production of molecular mediator of immune response", "Regulation of production of small rna involved in gene silencing by rna", "Regulation of programmed necrotic cell death", "Regulation of prostaglandin secretion", "Regulation of proteasomal protein catabolic process", "Regulation of proteasomal ubiquitin dependent protein catabolic process", "Regulation of protein acetylation", "Regulation of protein adp ribosylation", "Regulation of protein autophosphorylation", "Regulation of protein autoubiquitination", "Regulation of protein binding", "Regulation of protein catabolic process", "Regulation of protein catabolic process in the vacuole", "Regulation of protein complex stability", "Regulation of protein containing complex assembly", "Regulation of protein containing complex disassembly", "Regulation of protein deacetylation", "Regulation of protein dephosphorylation", "Regulation of protein depolymerization", "Regulation of protein deubiquitination", "Regulation of protein exit from endoplasmic reticulum", "Regulation of protein export from nucleus", "Regulation of protein folding", "Regulation of protein glycosylation", "Regulation of protein import", "Regulation of protein k63 linked ubiquitination", "Regulation of protein kinase a signaling", "Regulation of protein kinase activity", "Regulation of protein kinase c signaling", "Regulation of protein lipidation", "Regulation of protein localization", "Regulation of protein localization to cell cortex", "Regulation of protein localization to cell periphery", "Regulation of protein localization to cell surface", "Regulation of protein localization to centrosome", "Regulation of protein localization to chromatin", "Regulation of protein localization to chromosome telomeric region", "Regulation of protein localization to cilium", "Regulation of protein localization to endosome", "Regulation of protein localization to membrane", "Regulation of protein localization to nucleolus", "Regulation of protein localization to nucleus", "Regulation of protein localization to plasma membrane", "Regulation of protein localization to synapse", "Regulation of protein maturation", "Regulation of protein modification by small protein conjugation or removal", "Regulation of protein modification process", "Regulation of protein monoubiquitination", "Regulation of protein neddylation", "Regulation of protein phosphorylation", "Regulation of protein polymerization", "Regulation of protein polyubiquitination", "Regulation of protein secretion", "Regulation of protein serine threonine kinase activity", "Regulation of protein stability", "Regulation of protein sumoylation", "Regulation of protein targeting", "Regulation of protein targeting to membrane", "Regulation of protein tyrosine kinase activity", "Regulation of protein tyrosine phosphatase activity", "Regulation of proteolysis", "Regulation of proton transport", "Regulation of rac protein signal transduction", "Regulation of ras protein signal transduction", "Regulation of reactive oxygen species biosynthetic process", "Regulation of reactive oxygen species metabolic process", "Regulation of receptor binding", "Regulation of receptor catabolic process", "Regulation of receptor clustering", "Regulation of receptor internalization", "Regulation of receptor localization to synapse", "Regulation of receptor mediated endocytosis", "Regulation of receptor mediated endocytosis involved in cholesterol transport", "Regulation of receptor recycling", "Regulation of receptor signaling pathway via stat", "Regulation of regulated secretory pathway", "Regulation of relaxation of cardiac muscle", "Regulation of relaxation of muscle", "Regulation of release of cytochrome c from mitochondria", "Regulation of release of sequestered calcium ion into cytosol", "Regulation of removal of superoxide radicals", "Regulation of renal system process", "Regulation of reproductive process", "Regulation of respiratory burst", "Regulation of respiratory gaseous exchange", "Regulation of respiratory gaseous exchange by nervous system process", "Regulation of respiratory system process", "Regulation of response to biotic stimulus", "Regulation of response to cytokine stimulus", "Regulation of response to dna damage stimulus", "Regulation of response to endoplasmic reticulum stress", "Regulation of response to external stimulus", "Regulation of response to extracellular stimulus", "Regulation of response to food", "Regulation of response to interferon gamma", "Regulation of response to osmotic stress", "Regulation of response to oxidative stress", "Regulation of response to reactive oxygen species", "Regulation of response to stress", "Regulation of response to tumor cell", "Regulation of response to wounding", "Regulation of retinal ganglion cell axon guidance", "Regulation of retinoic acid receptor signaling pathway", "Regulation of retrograde protein transport er to cytosol", "Regulation of retrograde transport endosome to golgi", "Regulation of rho dependent protein serine threonine kinase activity", "Regulation of rho protein signal transduction", "Regulation of rhodopsin mediated signaling pathway", "Regulation of ribonuclease activity", "Regulation of ribosome biogenesis", "Regulation of rig i signaling pathway", "Regulation of rna binding", "Regulation of rna export from nucleus", "Regulation of rna polymerase ii regulatory region sequence specific dna binding", "Regulation of rna polymerase ii transcription preinitiation complex assembly", "Regulation of rna splicing", "Regulation of rrna processing", "Regulation of ruffle assembly", "Regulation of ryanodine sensitive calcium release channel activity", "Regulation of sarcomere organization", "Regulation of secondary heart field cardioblast proliferation", "Regulation of secretion", "Regulation of sequestering of triglyceride", "Regulation of sequestering of zinc ion", "Regulation of short term neuronal synaptic plasticity", "Regulation of signal transduction by p53 class mediator", "Regulation of signaling receptor activity", "Regulation of sister chromatid cohesion", "Regulation of skeletal muscle adaptation", "Regulation of skeletal muscle cell differentiation", "Regulation of skeletal muscle contraction", "Regulation of skeletal muscle contraction by calcium ion signaling", "Regulation of skeletal muscle tissue development", "Regulation of smad protein complex assembly", "Regulation of smad protein signal transduction", "Regulation of small gtpase mediated signal transduction", "Regulation of small molecule metabolic process", "Regulation of smooth muscle cell chemotaxis", "Regulation of smooth muscle cell differentiation", "Regulation of smooth muscle contraction", "Regulation of smoothened signaling pathway", "Regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Regulation of snrna transcription by rna polymerase ii", "Regulation of sodium ion transmembrane transport", "Regulation of sodium ion transport", "Regulation of sodium proton antiporter activity", "Regulation of spindle assembly", "Regulation of spindle organization", "Regulation of spontaneous synaptic transmission", "Regulation of sprouting angiogenesis", "Regulation of stem cell differentiation", "Regulation of stem cell population maintenance", "Regulation of stem cell proliferation", "Regulation of steroid biosynthetic process", "Regulation of steroid hormone biosynthetic process", "Regulation of steroid metabolic process", "Regulation of sterol transport", "Regulation of stress activated protein kinase signaling cascade", "Regulation of stress granule assembly", "Regulation of striated muscle cell differentiation", "Regulation of striated muscle contraction", "Regulation of substrate adhesion dependent cell spreading", "Regulation of sulfur metabolic process", "Regulation of superoxide anion generation", "Regulation of superoxide dismutase activity", "Regulation of superoxide metabolic process", "Regulation of supramolecular fiber organization", "Regulation of synapse assembly", "Regulation of synapse maturation", "Regulation of synapse structural plasticity", "Regulation of synapse structure or activity", "Regulation of synaptic plasticity", "Regulation of synaptic transmission dopaminergic", "Regulation of synaptic transmission gabaergic", "Regulation of synaptic transmission glutamatergic", "Regulation of synaptic vesicle endocytosis", "Regulation of synaptic vesicle exocytosis", "Regulation of synaptic vesicle priming", "Regulation of synaptic vesicle recycling", "Regulation of syncytium formation by plasma membrane fusion", "Regulation of system process", "Regulation of systemic arterial blood pressure", "Regulation of systemic arterial blood pressure by endothelin", "Regulation of systemic arterial blood pressure by hormone", "Regulation of systemic arterial blood pressure by renin angiotensin", "Regulation of systemic arterial blood pressure mediated by a chemical signal", "Regulation of t cell activation", "Regulation of t cell apoptotic process", "Regulation of t cell chemotaxis", "Regulation of t cell differentiation", "Regulation of t cell differentiation in thymus", "Regulation of t cell mediated cytotoxicity", "Regulation of t cell mediated immune response to tumor cell", "Regulation of t cell mediated immunity", "Regulation of t cell migration", "Regulation of t cell proliferation", "Regulation of t cell receptor signaling pathway", "Regulation of t circle formation", "Regulation of t helper 1 cell differentiation", "Regulation of t helper 1 type immune response", "Regulation of t helper 2 cell differentiation", "Regulation of t helper cell differentiation", "Regulation of tau protein kinase activity", "Regulation of telomerase activity", "Regulation of telomere capping", "Regulation of telomere maintenance", "Regulation of telomere maintenance via telomere lengthening", "Regulation of tetrapyrrole metabolic process", "Regulation of the force of heart contraction", "Regulation of thymocyte apoptotic process", "Regulation of tissue remodeling", "Regulation of tolerance induction", "Regulation of toll like receptor 3 signaling pathway", "Regulation of toll like receptor 4 signaling pathway", "Regulation of toll like receptor 7 signaling pathway", "Regulation of toll like receptor 9 signaling pathway", "Regulation of toll like receptor signaling pathway", "Regulation of tor signaling", "Regulation of torc2 signaling", "Regulation of trail activated apoptotic signaling pathway", "Regulation of trans synaptic signaling", "Regulation of transcription by glucose", "Regulation of transcription by rna polymerase i", "Regulation of transcription by rna polymerase iii", "Regulation of transcription elongation from rna polymerase ii promoter", "Regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Regulation of transcription from rna polymerase ii promoter in response to oxidative stress", "Regulation of transcription involved in g1 s transition of mitotic cell cycle", "Regulation of transcription of nucleolar large rrna by rna polymerase i", "Regulation of transcription regulatory region dna binding", "Regulation of transferase activity", "Regulation of transforming growth factor beta activation", "Regulation of transforming growth factor beta1 production", "Regulation of translation at synapse modulating synaptic transmission", "Regulation of translation in response to endoplasmic reticulum stress", "Regulation of translation in response to stress", "Regulation of translation initiation in response to endoplasmic reticulum stress", "Regulation of translational elongation", "Regulation of translational fidelity", "Regulation of translational initiation", "Regulation of translational initiation by eif2 alpha phosphorylation", "Regulation of translational initiation in response to stress", "Regulation of translational termination", "Regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Regulation of transmembrane transport", "Regulation of transmission of nerve impulse", "Regulation of transport", "Regulation of transporter activity", "Regulation of transposition", "Regulation of triglyceride biosynthetic process", "Regulation of triglyceride metabolic process", "Regulation of tube size", "Regulation of tumor necrosis factor mediated signaling pathway", "Regulation of type b pancreatic cell development", "Regulation of type i interferon mediated signaling pathway", "Regulation of ubiquitin dependent protein catabolic process", "Regulation of ubiquitin protein ligase activity", "Regulation of ubiquitin protein transferase activity", "Regulation of ubiquitin specific protease activity", "Regulation of unsaturated fatty acid biosynthetic process", "Regulation of urine volume", "Regulation of vacuole organization", "Regulation of vascular associated smooth muscle cell differentiation", "Regulation of vascular associated smooth muscle contraction", "Regulation of vascular endothelial growth factor receptor signaling pathway", "Regulation of vascular permeability", "Regulation of vascular wound healing", "Regulation of vasculature development", "Regulation of vasculogenesis", "Regulation of vasoconstriction", "Regulation of ventricular cardiac muscle cell action potential", "Regulation of very low density lipoprotein particle clearance", "Regulation of vesicle fusion", "Regulation of vesicle mediated transport", "Regulation of vesicle size", "Regulation of viral entry into host cell", "Regulation of viral genome replication", "Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Regulation of viral process", "Regulation of viral transcription", "Regulation of vitamin d receptor signaling pathway", "Regulation of vitamin metabolic process", "Regulation of voltage gated calcium channel activity", "Regulation of water loss via skin", "Regulation of wnt signaling pathway", "Regulation of wound healing", "Regulation of wound healing spreading of epidermal cells", "Relaxation of cardiac muscle", "Relaxation of muscle", "Release of cytochrome c from mitochondria", "Release of sequestered calcium ion into cytosol by endoplasmic reticulum", "Renal absorption", "Renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure", "Renal sodium excretion", "Renal sodium ion absorption", "Renal sodium ion transport", "Renal system process", "Renal system process involved in regulation of systemic arterial blood pressure", "Renal tubular secretion", "Renal tubule development", "Renal vesicle development", "Renal vesicle formation", "Renal water homeostasis", "Replacement ossification", "Replication born double strand break repair via sister chromatid exchange", "Replication fork processing", "Replication fork protection", "Replicative senescence", "Reproduction", "Reproductive behavior", "Reproductive system development", "Rescue of stalled ribosome", "Resolution of meiotic recombination intermediates", "Resolution of recombination intermediates", "Respiratory burst", "Respiratory burst involved in defense response", "Respiratory burst involved in inflammatory response", "Respiratory chain complex iii assembly", "Respiratory chain complex iv assembly", "Respiratory electron transport chain", "Respiratory gaseous exchange by respiratory system", "Respiratory system development", "Respiratory system process", "Response to abiotic stimulus", "Response to acetylcholine", "Response to acid chemical", "Response to acidic ph", "Response to actinomycin d", "Response to activity", "Response to alcohol", "Response to aldosterone", "Response to alkaloid", "Response to amine", "Response to amino acid starvation", "Response to ammonium ion", "Response to amphetamine", "Response to amyloid beta", "Response to angiotensin", "Response to antibiotic", "Response to arsenic containing substance", "Response to arsenite ion", "Response to atp", "Response to auditory stimulus", "Response to axon injury", "Response to bacterium", "Response to bmp", "Response to cadmium ion", "Response to caffeine", "Response to calcium ion", "Response to camp", "Response to camptothecin", "Response to carbohydrate", "Response to catecholamine", "Response to cell cycle checkpoint signaling", "Response to chemokine", "Response to cisplatin", "Response to cobalt ion", "Response to cocaine", "Response to cold", "Response to copper ion", "Response to corticosteroid", "Response to corticosterone", "Response to cortisol", "Response to cytokine", "Response to dexamethasone", "Response to dietary excess", "Response to dopamine", "Response to dsrna", "Response to electrical stimulus", "Response to endogenous stimulus", "Response to endoplasmic reticulum stress", "Response to epidermal growth factor", "Response to epinephrine", "Response to estradiol", "Response to estrogen", "Response to ethanol", "Response to ether", "Response to extracellular stimulus", "Response to fatty acid", "Response to fibroblast growth factor", "Response to fluid shear stress", "Response to folic acid", "Response to follicle stimulating hormone", "Response to food", "Response to fungus", "Response to gamma radiation", "Response to glucagon", "Response to glycoside", "Response to gonadotropin", "Response to growth factor", "Response to growth hormone", "Response to heat", "Response to heparin", "Response to hepatocyte growth factor", "Response to herbicide", "Response to histamine", "Response to hormone", "Response to hydrogen peroxide", "Response to hydroperoxide", "Response to hydrostatic pressure", "Response to hydroxyurea", "Response to hyperoxia", "Response to immobilization stress", "Response to increased oxygen levels", "Response to indole 3 methanol", "Response to inorganic substance", "Response to insecticide", "Response to insulin", "Response to interferon alpha", "Response to interferon beta", "Response to interferon gamma", "Response to interleukin 1", "Response to interleukin 12", "Response to interleukin 3", "Response to interleukin 4", "Response to interleukin 6", "Response to interleukin 7", "Response to ionizing radiation", "Response to iron ii ion", "Response to iron ion", "Response to ischemia", "Response to isoquinoline alkaloid", "Response to ketone", "Response to l ascorbic acid", "Response to l glutamate", "Response to l phenylalanine derivative", "Response to lead ion", "Response to lectin", "Response to leptin", "Response to leucine", "Response to leukemia inhibitory factor", "Response to light intensity", "Response to light stimulus", "Response to lipid", "Response to lithium ion", "Response to magnesium ion", "Response to manganese ion", "Response to mechanical stimulus", "Response to mercury ion", "Response to metal ion", "Response to methylmercury", "Response to mineralocorticoid", "Response to misfolded protein", "Response to mitochondrial depolarisation", "Response to molecule of bacterial origin", "Response to monosaccharide", "Response to muramyl dipeptide", "Response to muscle activity", "Response to muscle stretch", "Response to nerve growth factor", "Response to nicotine", "Response to nitric oxide", "Response to nitrogen compound", "Response to nitrosative stress", "Response to nutrient", "Response to oleic acid", "Response to organic cyclic compound", "Response to osmotic stress", "Response to oxidative stress", "Response to oxygen containing compound", "Response to oxygen glucose deprivation", "Response to oxygen levels", "Response to oxygen radical", "Response to pain", "Response to parathyroid hormone", "Response to peptide", "Response to peptide hormone", "Response to peptidoglycan", "Response to ph", "Response to phorbol 13 acetate 12 myristate", "Response to platelet derived growth factor", "Response to potassium ion", "Response to progesterone", "Response to prostaglandin", "Response to prostaglandin e", "Response to purine containing compound", "Response to radiation", "Response to reactive oxygen species", "Response to redox state", "Response to retinoic acid", "Response to salt", "Response to salt stress", "Response to selenium ion", "Response to sodium arsenite", "Response to starvation", "Response to steroid hormone", "Response to sterol depletion", "Response to temperature stimulus", "Response to testosterone", "Response to thyroglobulin triiodothyronine", "Response to thyroid hormone", "Response to thyroxine", "Response to topologically incorrect protein", "Response to toxic substance", "Response to transforming growth factor beta", "Response to tumor cell", "Response to tumor necrosis factor", "Response to type i interferon", "Response to uv", "Response to uv a", "Response to uv b", "Response to uv c", "Response to virus", "Response to vitamin", "Response to vitamin a", "Response to vitamin d", "Response to vitamin e", "Response to vitamin k", "Response to water", "Response to wounding", "Response to x ray", "Response to xenobiotic stimulus", "Response to zinc ion", "Reticulophagy", "Retina development in camera type eye", "Retina homeostasis", "Retina layer formation", "Retina morphogenesis in camera type eye", "Retinal cell apoptotic process", "Retinal cone cell differentiation", "Retinal ganglion cell axon guidance", "Retinal metabolic process", "Retinal rod cell development", "Retinal rod cell differentiation", "Retinoic acid metabolic process", "Retinoic acid receptor signaling pathway", "Retinol metabolic process", "Retrograde axonal transport", "Retrograde transport endosome to golgi", "Retrograde transport vesicle recycling within golgi", "Retrograde vesicle mediated transport golgi to endoplasmic reticulum", "Reverse cholesterol transport", "Reversible differentiation", "Rho protein signal transduction", "Rhodopsin mediated signaling pathway", "Rhythmic behavior", "Rhythmic process", "Riboflavin metabolic process", "Ribonucleoprotein complex biogenesis", "Ribonucleoprotein complex disassembly", "Ribonucleoprotein complex localization", "Ribonucleoprotein complex subunit organization", "Ribonucleoside catabolic process", "Ribonucleoside diphosphate biosynthetic process", "Ribonucleoside diphosphate catabolic process", "Ribonucleoside diphosphate metabolic process", "Ribonucleoside metabolic process", "Ribonucleoside monophosphate biosynthetic process", "Ribonucleoside monophosphate catabolic process", "Ribonucleoside monophosphate metabolic process", "Ribonucleoside triphosphate biosynthetic process", "Ribonucleoside triphosphate metabolic process", "Ribonucleotide catabolic process", "Ribose phosphate biosynthetic process", "Ribose phosphate metabolic process", "Ribosomal large subunit assembly", "Ribosomal large subunit biogenesis", "Ribosomal large subunit export from nucleus", "Ribosomal small subunit assembly", "Ribosomal small subunit biogenesis", "Ribosomal small subunit export from nucleus", "Ribosomal subunit export from nucleus", "Ribosome assembly", "Ribosome associated ubiquitin dependent protein catabolic process", "Ribosome biogenesis", "Ribosome disassembly", "Rig i signaling pathway", "Righting reflex", "Rna 3 end processing", "Rna 5 end processing", "Rna capping", "Rna catabolic process", "Rna decapping", "Rna dependent dna biosynthetic process", "Rna destabilization", "Rna export from nucleus", "Rna guanine n7 methylation", "Rna import into mitochondrion", "Rna interference", "Rna localization", "Rna mediated gene silencing by inhibition of translation", "Rna methylation", "Rna modification", "Rna phosphodiester bond hydrolysis", "Rna phosphodiester bond hydrolysis endonucleolytic", "Rna phosphodiester bond hydrolysis exonucleolytic", "Rna polyadenylation", "Rna polymerase i preinitiation complex assembly", "Rna polymerase ii preinitiation complex assembly", "Rna processing", "Rna secondary structure unwinding", "Rna splicing", "Rna splicing via endonucleolytic cleavage and ligation", "Rna splicing via transesterification reactions", "Rna stabilization", "Rna surveillance", "Roof of mouth development", "Roundabout signaling pathway", "Rrna 3 end processing", "Rrna 5 end processing", "Rrna base methylation", "Rrna catabolic process", "Rrna metabolic process", "Rrna methylation", "Rrna modification", "Rrna pseudouridine synthesis", "Rrna transcription", "Rrna transport", "Ruffle assembly", "Ruffle organization", "S adenosylmethionine cycle", "S adenosylmethionine metabolic process", "Salivary gland development", "Sarcomere organization", "Sarcoplasmic reticulum calcium ion transport", "Satellite cell activation involved in skeletal muscle regeneration", "Scarna localization to cajal body", "Scf dependent proteasomal ubiquitin dependent protein catabolic process", "Schwann cell development", "Schwann cell differentiation", "Schwann cell proliferation", "Second messenger mediated signaling", "Secondary alcohol metabolic process", "Secondary metabolic process", "Secretion", "Secretion by tissue", "Secretory granule localization", "Secretory granule organization", "Segmentation", "Selective autophagy", "Self proteolysis", "Semaphorin plexin signaling pathway", "Semaphorin plexin signaling pathway involved in neuron projection guidance", "Semi lunar valve development", "Sensory organ development", "Sensory organ morphogenesis", "Sensory perception", "Sensory perception of light stimulus", "Sensory perception of mechanical stimulus", "Sensory perception of pain", "Sensory system development", "Septum primum development", "Sequestering of actin monomers", "Sequestering of calcium ion", "Sequestering of iron ion", "Sequestering of metal ion", "Sequestering of triglyceride", "Sequestering of zinc ion", "Serine family amino acid biosynthetic process", "Serine family amino acid catabolic process", "Serine family amino acid metabolic process", "Serine phosphorylation of stat protein", "Serine transport", "Serotonin metabolic process", "Sertoli cell development", "Sertoli cell differentiation", "Sex determination", "Sex differentiation", "Short chain fatty acid catabolic process", "Short chain fatty acid metabolic process", "Short term memory", "Signal peptide processing", "Signal release", "Signal transduction by p53 class mediator", "Signal transduction in absence of ligand", "Signal transduction in response to dna damage", "Signal transduction involved in regulation of gene expression", "Signaling receptor ligand precursor processing", "Single fertilization", "Single strand break repair", "Single stranded viral rna replication via double stranded dna intermediate", "Sister chromatid cohesion", "Sister chromatid segregation", "Skeletal muscle acetylcholine gated channel clustering", "Skeletal muscle adaptation", "Skeletal muscle cell differentiation", "Skeletal muscle cell proliferation", "Skeletal muscle contraction", "Skeletal muscle fiber differentiation", "Skeletal muscle organ development", "Skeletal muscle satellite cell activation", "Skeletal muscle tissue regeneration", "Skeletal myofibril assembly", "Skeletal system development", "Skeletal system morphogenesis", "Skin development", "Skin epidermis development", "Skin morphogenesis", "Smad protein complex assembly", "Smad protein signal transduction", "Small gtpase mediated signal transduction", "Small molecule biosynthetic process", "Small molecule catabolic process", "Small molecule metabolic process", "Small nucleolar ribonucleoprotein complex assembly", "Small rna loading onto risc", "Smooth muscle adaptation", "Smooth muscle cell apoptotic process", "Smooth muscle cell chemotaxis", "Smooth muscle cell differentiation", "Smooth muscle cell migration", "Smooth muscle cell proliferation", "Smooth muscle contraction", "Smoothened signaling pathway", "Smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Sno s rna metabolic process", "Sno s rna processing", "Snorna localization", "Snrna metabolic process", "Snrna modification", "Snrna processing", "Snrna transcription", "Snrna transcription by rna polymerase ii", "Snrna transport", "Sodium ion export across plasma membrane", "Sodium ion homeostasis", "Sodium ion import across plasma membrane", "Sodium ion transmembrane transport", "Sodium ion transport", "Somatic diversification of immune receptors", "Somatic diversification of immune receptors via somatic mutation", "Somatic diversification of immunoglobulins", "Somatic diversification of immunoglobulins involved in immune response", "Somatic diversification of t cell receptor genes", "Somatic stem cell population maintenance", "Somite development", "Somitogenesis", "Specification of animal organ identity", "Specification of symmetry", "Sperm capacitation", "Sperm dna condensation", "Sperm egg recognition", "Sperm motility", "Spermatid differentiation", "Spermatid nucleus differentiation", "Spermatogenesis exchange of chromosomal proteins", "Spermidine metabolic process", "Sphingoid metabolic process", "Sphingolipid biosynthetic process", "Sphingolipid mediated signaling pathway", "Sphingolipid metabolic process", "Sphingolipid translocation", "Sphingomyelin biosynthetic process", "Sphingomyelin catabolic process", "Sphingomyelin metabolic process", "Sphingosine biosynthetic process", "Spinal cord development", "Spinal cord motor neuron differentiation", "Spindle assembly", "Spindle elongation", "Spindle localization", "Spindle midzone assembly", "Spindle organization", "Spleen development", "Spliceosomal complex assembly", "Spliceosomal conformational changes to generate catalytic conformation", "Spliceosomal snrnp assembly", "Spliceosomal tri snrnp complex assembly", "Spontaneous synaptic transmission", "Sprouting angiogenesis", "Srp dependent cotranslational protein targeting to membrane", "Srp dependent cotranslational protein targeting to membrane signal sequence recognition", "Srp dependent cotranslational protein targeting to membrane translocation", "Startle response", "Stem cell differentiation", "Stem cell division", "Stem cell proliferation", "Steroid biosynthetic process", "Steroid catabolic process", "Steroid esterification", "Steroid hormone biosynthetic process", "Steroid hormone mediated signaling pathway", "Steroid metabolic process", "Sterol biosynthetic process", "Sterol homeostasis", "Sterol import", "Sterol metabolic process", "Sterol transport", "Stress activated protein kinase signaling cascade", "Stress fiber assembly", "Stress granule assembly", "Stress granule disassembly", "Stress induced premature senescence", "Stress response to metal ion", "Striated muscle adaptation", "Striated muscle cell apoptotic process", "Striated muscle cell development", "Striated muscle cell differentiation", "Striated muscle cell proliferation", "Striated muscle contraction", "Striatum development", "Subpallium development", "Substantia nigra development", "Substrate adhesion dependent cell spreading", "Substrate dependent cell migration", "Substrate dependent cell migration cell extension", "Substrate independent telencephalic tangential migration", "Subtelomeric heterochromatin assembly", "Succinate metabolic process", "Succinate transmembrane transport", "Succinyl coa metabolic process", "Suckling behavior", "Sugar mediated signaling pathway", "Sulfate transport", "Sulfur amino acid biosynthetic process", "Sulfur amino acid catabolic process", "Sulfur amino acid metabolic process", "Sulfur compound biosynthetic process", "Sulfur compound catabolic process", "Sulfur compound metabolic process", "Sulfur compound transport", "Superoxide anion generation", "Superoxide metabolic process", "Suppression of viral release by host", "Supramolecular fiber organization", "Sympathetic ganglion development", "Sympathetic nervous system development", "Synapse assembly", "Synapse maturation", "Synapse organization", "Synapse pruning", "Synaptic assembly at neuromuscular junction", "Synaptic signaling", "Synaptic transmission dopaminergic", "Synaptic transmission gabaergic", "Synaptic transmission glutamatergic", "Synaptic vesicle budding", "Synaptic vesicle clustering", "Synaptic vesicle cytoskeletal transport", "Synaptic vesicle docking", "Synaptic vesicle endosomal processing", "Synaptic vesicle exocytosis", "Synaptic vesicle localization", "Synaptic vesicle maturation", "Synaptic vesicle membrane organization", "Synaptic vesicle priming", "Synaptic vesicle recycling", "Synaptic vesicle recycling via endosome", "Synaptic vesicle transport", "Synaptic vesicle uncoating", "Synaptonemal complex organization", "Syncytium formation", "T cell activation", "T cell activation involved in immune response", "T cell apoptotic process", "T cell chemotaxis", "T cell cytokine production", "T cell differentiation", "T cell differentiation in thymus", "T cell differentiation involved in immune response", "T cell extravasation", "T cell homeostasis", "T cell lineage commitment", "T cell mediated cytotoxicity", "T cell mediated immune response to tumor cell", "T cell mediated immunity", "T cell migration", "T cell proliferation", "T cell proliferation involved in immune response", "T cell receptor signaling pathway", "T cell selection", "T cell tolerance induction", "T helper 1 cell differentiation", "T helper 1 type immune response", "T helper 17 cell differentiation", "T helper 17 cell lineage commitment", "T helper 17 type immune response", "T helper 2 cell differentiation", "T helper cell lineage commitment", "T tubule organization", "Tail anchored membrane protein insertion into er membrane", "Tangential migration from the subventricular zone to the olfactory bulb", "Taxis", "Telencephalon development", "Telencephalon glial cell migration", "Telencephalon regionalization", "Telomerase holoenzyme complex assembly", "Telomerase rna localization", "Telomere capping", "Telomere maintenance", "Telomere maintenance in response to dna damage", "Telomere maintenance via recombination", "Telomere maintenance via semi conservative replication", "Telomere maintenance via telomere lengthening", "Telomere organization", "Telomeric d loop disassembly", "Telomeric loop disassembly", "Temperature homeostasis", "Terminal button organization", "Termination of rna polymerase ii transcription", "Terpenoid biosynthetic process", "Terpenoid metabolic process", "Tertiary alcohol metabolic process", "Tetrahydrobiopterin metabolic process", "Tetrahydrofolate biosynthetic process", "Tetrahydrofolate interconversion", "Tetrahydrofolate metabolic process", "Tetrapyrrole biosynthetic process", "Tetrapyrrole catabolic process", "Tetrapyrrole metabolic process", "Thalamus development", "Thiamine containing compound metabolic process", "Thiamine transport", "Thioester biosynthetic process", "Thioester metabolic process", "Thorax and anterior abdomen determination", "Threonine catabolic process", "Threonine metabolic process", "Thrombin activated receptor signaling pathway", "Thrombopoietin mediated signaling pathway", "Thymocyte apoptotic process", "Thymus development", "Thyroid gland development", "Thyroid hormone mediated signaling pathway", "Tight junction organization", "Tissue development", "Tissue migration", "Tissue morphogenesis", "Tissue regeneration", "Tissue remodeling", "Tolerance induction", "Toll like receptor 3 signaling pathway", "Toll like receptor 4 signaling pathway", "Toll like receptor 7 signaling pathway", "Toll like receptor 8 signaling pathway", "Toll like receptor 9 signaling pathway", "Toll like receptor signaling pathway", "Tongue development", "Tongue morphogenesis", "Tooth mineralization", "Tor signaling", "Torc1 signaling", "Torc2 signaling", "Toxin metabolic process", "Toxin transport", "Trabecula morphogenesis", "Trachea development", "Trachea formation", "Trachea morphogenesis", "Trail activated apoptotic signaling pathway", "Trans synaptic signaling by trans synaptic complex", "Trans synaptic signaling modulating synaptic transmission", "Transcription by rna polymerase i", "Transcription by rna polymerase iii", "Transcription coupled nucleotide excision repair", "Transcription dependent tethering of rna polymerase ii gene dna at nuclear periphery", "Transcription elongation from rna polymerase i promoter", "Transcription elongation from rna polymerase ii promoter", "Transcription initiation from rna polymerase i promoter", "Transcription initiation from rna polymerase ii promoter", "Transcription initiation from rna polymerase iii promoter", "Transcription preinitiation complex assembly", "Transcytosis", "Transdifferentiation", "Transepithelial chloride transport", "Transepithelial transport", "Transferrin transport", "Transforming growth factor beta activation", "Transforming growth factor beta production", "Transforming growth factor beta receptor signaling pathway", "Transforming growth factor beta1 production", "Transition between fast and slow fiber", "Transition metal ion homeostasis", "Transition metal ion transport", "Translational elongation", "Translational initiation", "Translational readthrough", "Translational termination", "Translesion synthesis", "Translocation of molecules into host", "Transmembrane receptor protein serine threonine kinase signaling pathway", "Transmembrane receptor protein tyrosine kinase signaling pathway", "Transmembrane transport", "Transmission of nerve impulse", "Transport along microtubule", "Transport of virus", "Transposition", "Transposition rna mediated", "Tricarboxylic acid cycle", "Tricarboxylic acid metabolic process", "Triglyceride biosynthetic process", "Triglyceride metabolic process", "Tripartite regional subdivision", "Tripeptide transmembrane transport", "Tripeptide transport", "Trivalent inorganic anion homeostasis", "Trna 3 end processing", "Trna 5 end processing", "Trna 5 leader removal", "Trna aminoacylation for mitochondrial protein translation", "Trna catabolic process", "Trna metabolic process", "Trna methylation", "Trna modification", "Trna processing", "Trna pseudouridine synthesis", "Trna thio modification", "Trna threonylcarbamoyladenosine metabolic process", "Trna transcription", "Trna transport", "Trna wobble base modification", "Trna wobble uridine modification", "Trophectodermal cell differentiation", "Trophoblast cell migration", "Trophoblast giant cell differentiation", "Tryptophan transport", "Tube development", "Tube formation", "Tube morphogenesis", "Tubulin complex assembly", "Tubulin deacetylation", "Tumor necrosis factor mediated signaling pathway", "Tumor necrosis factor superfamily cytokine production", "Type 2 immune response", "Type b pancreatic cell apoptotic process", "Type b pancreatic cell development", "Type i interferon production", "Type i pneumocyte differentiation", "Tyrosine catabolic process", "Tyrosine metabolic process", "Tyrosine phosphorylation of stat protein", "U4 snrna 3 end processing", "Ubiquinone metabolic process", "Ubiquitin dependent endocytosis", "Ubiquitin dependent erad pathway", "Ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin dependent smad protein catabolic process", "Ubiquitin independent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin recycling", "Udp glucose metabolic process", "Udp n acetylglucosamine biosynthetic process", "Udp n acetylglucosamine metabolic process", "Ump biosynthetic process", "Unsaturated fatty acid biosynthetic process", "Unsaturated fatty acid metabolic process", "Urate metabolic process", "Urate transport", "Urea cycle", "Urea metabolic process", "Ureter development", "Urinary bladder smooth muscle contraction", "Urinary tract smooth muscle contraction", "Urogenital system development", "Uronic acid metabolic process", "Uterus development", "Uterus morphogenesis", "Utp biosynthetic process", "Utp metabolic process", "Uv damage excision repair", "Uv protection", "V d j recombination", "Vacuolar acidification", "Vacuolar localization", "Vacuolar transport", "Vacuole organization", "Valine metabolic process", "Vascular associated smooth muscle cell apoptotic process", "Vascular associated smooth muscle cell differentiation", "Vascular associated smooth muscle cell migration", "Vascular associated smooth muscle cell proliferation", "Vascular associated smooth muscle contraction", "Vascular endothelial cell proliferation", "Vascular endothelial growth factor production", "Vascular endothelial growth factor receptor 2 signaling pathway", "Vascular endothelial growth factor receptor signaling pathway", "Vascular endothelial growth factor signaling pathway", "Vascular process in circulatory system", "Vascular transport", "Vascular wound healing", "Vasculature development", "Vasculogenesis", "Vasoconstriction", "Vasodilation", "Ventral spinal cord development", "Ventricular cardiac muscle cell action potential", "Ventricular cardiac muscle cell development", "Ventricular cardiac muscle cell differentiation", "Ventricular cardiac muscle cell membrane repolarization", "Ventricular cardiac muscle tissue development", "Ventricular cardiac muscle tissue morphogenesis", "Ventricular compact myocardium morphogenesis", "Ventricular septum development", "Ventricular septum morphogenesis", "Ventricular system development", "Very long chain fatty acid catabolic process", "Very long chain fatty acid metabolic process", "Very low density lipoprotein particle assembly", "Very low density lipoprotein particle clearance", "Vesicle budding from membrane", "Vesicle cargo loading", "Vesicle cytoskeletal trafficking", "Vesicle docking", "Vesicle docking involved in exocytosis", "Vesicle fusion to plasma membrane", "Vesicle fusion with golgi apparatus", "Vesicle localization", "Vesicle mediated transport", "Vesicle mediated transport between endosomal compartments", "Vesicle mediated transport in synapse", "Vesicle mediated transport to the plasma membrane", "Vesicle organization", "Vesicle targeting", "Vesicle targeting rough er to cis golgi", "Vesicle targeting to from or within golgi", "Vesicle tethering", "Vesicle tethering to golgi", "Vesicle transport along microtubule", "Vesicle uncoating", "Viral budding", "Viral gene expression", "Viral genome replication", "Viral life cycle", "Viral process", "Viral protein processing", "Viral release from host cell", "Viral rna genome replication", "Viral transcription", "Viral translation", "Viral translational termination reinitiation", "Virion assembly", "Virion attachment to host cell", "Visual behavior", "Vitamin a metabolic process", "Vitamin b6 metabolic process", "Vitamin biosynthetic process", "Vitamin catabolic process", "Vitamin d metabolic process", "Vitamin d receptor signaling pathway", "Vitamin k metabolic process", "Vitamin metabolic process", "Vitamin transmembrane transport", "Vitamin transport", "Vocalization behavior", "Voluntary musculoskeletal movement", "Walking behavior", "Water homeostasis", "Water soluble vitamin biosynthetic process", "Water soluble vitamin metabolic process", "Water transport", "White fat cell differentiation", "Wnt protein secretion", "Wnt signaling pathway involved in heart development", "Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "Wound healing", "Wound healing involved in inflammatory response", "Wound healing spreading of epidermal cells", "Xenobiotic catabolic process", "Xenobiotic export", "Xenobiotic metabolic process", "Xenobiotic transmembrane transport", "Xenobiotic transport", "Xenobiotic transport across blood brain barrier", "Xmp metabolic process", "Zinc ion homeostasis", "Zygotic determination of anterior posterior axis embryo", "Zymogen activation", "Zymogen inhibition"], "available_proteins": ["AAAS", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ACTR6", "ADAM17", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC5", "ANAPC7", "ANK3", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APOL2", "APOO", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG4B", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "B4GAT1", "BABAM1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCL2L12", "BCLAF1", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPTF", "BRCA1", "BRD2", "BRIX1", "BRMS1L", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BYSL", "BZW1", "C12orf43", "C12orf73", "C19orf70", "C1QBP", "CACYBP", "CAD", "CALD1", "CALR", "CAMK2D", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC47", "CCDC6", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD3EAP", "CDC123", "CDC23", "CDC27", "CDC34", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKAL1", "CEBPZ", "CECR2", "CELF1", "CENPI", "CERS2", "CFAP20", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD4", "CHERP", "CHID1", "CHKA", "CHMP3", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIAPIN1", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT10", "CNOT3", "CNOT6", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COG7", "COIL", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "CORO1B", "CORO1C", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DGCR8", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPF2", "DPH2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "ENSA", "ENY2", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERH", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAM120B", "FAM162A", "FAM208A", "FAM49B", "FAM8A1", "FAM98A", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FOXK1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GIGYF2", "GINS1", "GINS4", "GLA", "GLB1", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLGB1", "GORASP2", "GOT1", "GOT2", "GPAA1", "GPATCH4", "GPD2", "GPI", "GPR107", "GPR108", "GPS1", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAUS5", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIC2", "HIF1AN", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HOXA10", "HP1BP3", "HPF1", "HPRT1", "HPS6", "HSD17B10", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMPDH2", "INA", "INCENP", "INF2", "INTS11", "INTS14", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRS4", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC2", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMP1", "LAMTOR1", "LAMTOR2", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDAH", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3BP", "LGMN", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L3", "LYAR", "LYPLA1", "MACF1", "MAGED2", "MAGT1", "MAK16", "MAP1B", "MAP1S", "MAP2K1", "MAP4", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARCKSL1", "MARK2", "MARS", "MAT2A", "MATR3", "MAU2", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED16", "METAP2", "METTL13", "MFN1", "MFN2", "MGEA5", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMGT1", "MMS19", "MOGS", "MORF4L1", "MOV10", "MPHOSPH10", "MPI", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL44", "MRPL47", "MRPL58", "MRPL9", "MRPS11", "MRPS2", "MRPS27", "MRPS30", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MYBBP1A", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFAF7", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFCD", "NEMF", "NENF", "NES", "NEU1", "NHP2", "NIFK", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL11", "NOL6", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NPTN", "NRBP1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "OAT", "OCIAD1", "OCLN", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL11", "OSBPL6", "OSBPL9", "OTUB1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIGS", "PIGT", "PIN4", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLAA", "PLBD2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1R10", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PPP6R3", "PPT1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTRH2", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RABGGTA", "RAC1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAD51AP1", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM39", "RBM4", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "RECQL5", "REEP5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIF1", "RINT1", "RIOK2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF114", "RNF20", "RNF40", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF8", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC3A2", "SLC6A15", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX2", "SNX3", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPCS2", "SPCS3", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SQLE", "SQSTM1", "SRCAP", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSRP1", "SSU72", "STAG2", "STARD3", "STAT3", "STAU1", "STAU2", "STEAP3", "STIP1", "STMN1", "STOML2", "STRAP", "STRBP", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TACO1", "TAF15", "TAGLN2", "TALDO1", "TAMM41", "TAP1", "TAP2", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF25", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TFAM", "TFG", "TFRC", "THG1L", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIPRL", "TJP1", "TJP2", "TK1", "TKT", "TLN1", "TM9SF3", "TMCO1", "TMED10", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM126B", "TMEM201", "TMEM214", "TMEM230", "TMEM33", "TMEM43", "TMEM65", "TMEM97", "TMOD3", "TMTC3", "TMX1", "TMX2", "TNKS1BP1", "TNPO1", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TP53", "TP53BP1", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC5", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRMT6", "TRMU", "TRNT1", "TROVE2", "TSC2", "TSFM", "TSG101", "TSN", "TSPAN6", "TSR1", "TSTA3", "TTC1", "TTC19", "TTC21B", "TTC26", "TTC37", "TTC4", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBL5", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UCHL5", "UFC1", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF3B", "UQCR10", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USO1", "USP10", "USP14", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VPS13A", "VPS16", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WBP11", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR43", "WDR45B", "WDR46", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIZ", "WRAP53", "XAB2", "XPNPEP1", "XPO1", "XPO4", "XPO5", "XPO7", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YEATS2", "YEATS4", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBTB10", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZDHHC20", "ZFYVE16", "ZMPSTE24", "ZMYM4", "ZNF148", "ZNF281", "ZNF318", "ZNF326", "ZNF638", "ZRANB2", "ZW10", "ZYX"], "leading_proteins": ["AARS2", "AASDHPPT", "ABCB1", "ABCC4", "ABCD3", "ABHD10", "ACADS", "ACADVL", "ACO1", "ACOT7", "ACOX1", "ACP2", "ACTL6A", "ADAM17", "AGK", "AIFM1", "AIMP2", "AIP", "AK1", "AK2", "AK6", "AKAP13", "AKAP8L", "AKR1A1", "AKR1B1", "AKT2", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALYREF", "ANK3", "ANKLE2", "ANP32B", "ANXA1", "ANXA2", "AP2M1", "AP3S1", "APEX1", "APLP2", "APOL2", "APP", "ARCN1", "ARF4", "ARFGAP1", "ARID1A", "ARIH1", "ARL1", "ARL6IP1", "ARL6IP5", "ARMCX3", "ASAH1", "ASNA1", "ATAD1", "ATG4B", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5J2", "ATP5L", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1E1", "ATPIF1", "AUP1", "B4GAT1", "BABAM2", "BAG6", "BAIAP2", "BASP1", "BAZ2A", "BCAP31", "BCAT2", "BCL2L12", "BLMH", "BRCA1", "BRMS1L", "BTF3", "BYSL", "C12orf73", "C19orf70", "C1QBP", "CALR", "CAMLG", "CAPN2", "CARM1", "CAST", "CBX3", "CCDC47", "CD2AP", "CDC23", "CDC42", "CDK1", "CDK12", "CDK2", "CDK5", "CERS2", "CHCHD3", "CHKA", "CHMP3", "CHMP7", "CHST14", "CIRBP", "CLASP1", "CLASP2", "CLN5", "CLPP", "CLPTM1", "CLUH", "CMAS", "CNNM4", "CNOT1", "CNOT10", "CNOT3", "CNOT6", "CNOT7", "CNOT9", "CNPY2", "COA3", "COMT", "COPS2", "COPS4", "COPS5", "COPS8", "COPZ1", "COTL1", "COX2", "COX4I1", "COX5A", "COX7A2", "CPSF6", "CPT2", "CRTAP", "CSK", "CTBP1", "CTPS1", "CTSA", "CTTN", "CUL4A", "CYB5B", "CYB5D2", "CYFIP1", "CYP51A1", "DARS2", "DAZAP1", "DBN1", "DCD", "DCPS", "DCTPP1", "DDB1", "DDX17", "DDX39A", "DDX39B", "DDX3X", "DDX49", "DDX5", "DERL1", "DGCR8", "DHCR24", "DHCR7", "DHFR", "DHPS", "DIABLO", "DIEXF", "DIS3", "DNAJB1", "DNAJC10", "DNAJC3", "DNM1L", "DNM2", "DSG2", "DSP", "DST", "DTYMK", "DUSP9", "DYNC1I2", "ECE1", "EIF2AK2", "EIF2S1", "EIF3E", "EIF5", "EIF6", "EMD", "EPHA7", "EPHX1", "ERAP1", "ERCC2", "ERGIC3", "ERO1A", "ERP29", "ERP44", "ETFA", "ETFDH", "EXO1", "EXOC3", "EXOSC1", "EXOSC3", "EXOSC6", "EXOSC7", "EZR", "F11R", "FAF1", "FAF2", "FAM49B", "FAM8A1", "FERMT2", "FHL1", "FKBP14", "FKBP7", "FLAD1", "FLOT1", "FMR1", "FN3KRP", "FOXC1", "FOXK1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "GAA", "GALNT1", "GAPDH", "GBA", "GBF1", "GCC2", "GET4", "GGCT", "GLA", "GLB1", "GLUD1", "GLYR1", "GM2A", "GNA13", "GNAI2", "GNAI3", "GNS", "GORASP2", "GPR107", "GPR108", "GRB2", "GRIPAP1", "GRSF1", "GSK3A", "GSTO1", "HADH", "HADHA", "HDAC1", "HEXB", "HIBADH", "HLA-C", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HPF1", "HPS6", "HSD17B10", "HSD17B12", "HSD17B4", "HSPA13", "HSPA1B", "HSPA8", "HSPB1", "HTRA2", "ICMT", "IDH1", "IDH2", "IFT27", "IKBIP", "INTS14", "IPO11", "IST1", "ITCH", "ITGB1", "JUP", "KDELR1", "KDM1A", "KDM2A", "KDSR", "KHSRP", "KIFBP", "KMT2A", "KNTC1", "LAMP1", "LAMTOR1", "LAMTOR2", "LARP4B", "LBR", "LDAH", "LEMD3", "LGALS3BP", "LGMN", "LIMA1", "LLGL1", "LMAN1", "LNPEP", "LPCAT1", "LRPAP1", "LSM6", "LSS", "LTA4H", "LYPLA1", "MAPRE2", "MFN1", "MFN2", 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0.0003514888174985 +Proteasome core complex beta subunit complex 5 7 2.3269246462379427 0.0199692761892675 3.699029126213592 6.970873786407767 1.6670727234653664 0.1509307531330224 1.4503762582219135 0.1681602725795027 0.9611878160538336 0.233503072382129 1.0 0.0424464003246627 0.0032139762811053 3.788095303003865e-05 8.872830475208381e-07 +Vacuole 41 163 2.2971429037179427 0.0216106189745919 55.029126213592235 212.35679611650485 0.7895788564169173 0.4204713883128338 16.092847298969616 21.031446114270427 2.221429361906059 0.4148180554719883 1.0 0.0051479490811534 7.106055552165301e-06 2.4409818209674115e-08 9.10009265384925e-06 +Endoplasmic reticulum lumen 12 50 2.260834440504281 0.0237695110424742 18.07766990291262 59.737864077669904 0.9896277047863468 0.3946249358858228 7.513340007333169 6.273245958458151 1.4320597420402308 0.3846324865730224 1.0 0.559981185156499 0.2259947926684591 0.0002227949702616 0.0072924037832047 +Secretory granule membrane 19 55 2.238855781076321 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0.0625314301217693 0.0180565405233996 0.0494824412948022 +Endocytic vesicle membrane 6 31 2.111480763240557 0.0347310096678414 11.41019417475728 40.75728155339806 0.6528171904926832 0.3529092384633215 4.825015011915381 4.780047567333447 1.5638167276319088 0.3380752375601685 1.0 0.4215392305763319 0.0971065943925469 0.0194178363725262 0.1761767748095188 +Tim23 mitochondrial import inner membrane translocase complex 2 6 2.096633576190672 0.0360260246450101 2.2694174757281553 6.342233009708738 1.5180442383336388 0.125307709046494 1.369833329272529 0.8106469094037756 1.2674744491900518 0.2021471972412396 1.0 0.0012105019492812 0.0048484802924912 0.001983278822638 0.0136322353881827 +Caveola 2 12 2.043771225535058 0.0409761530526 2.9466019417475726 14.70873786407767 0.8985606687711867 0.3693669899268542 1.8868639175868975 1.4590265937218798 0.8676345315740439 0.2906359774944637 1.0 0.0257535715284909 0.0905584027773802 0.1300529274831162 0.4593832053652316 +Cell surface 15 62 2.024777703467492 0.0428901955521385 21.233009708737864 77.5995145631068 0.4772545566224628 0.498248600191797 7.455308766626032 8.832436895439663 1.3320096182828691 0.3812427248674431 1.0 0.7859178232186557 0.8154651699745918 0.1404953813735639 0.2563028213322827 +Proton transporting two sector atpase complex proton transporting domain 6 9 2.01233302058255 0.0441848438407059 4.053398058252427 10.283980582524272 1.020958321179617 0.2307004649223604 1.8491832641634656 1.1862626633334956 1.3576055733210162 0.273185751006507 1.0 1.0 0.0090253131212995 0.000366006536683 2.6076404564241632e-06 +Respiratory chain complex iv 3 9 1.972279801594907 0.0485776741071377 3.754854368932039 9.74271844660194 0.8119042784517004 0.2590637228606872 2.032646352020888 1.0643473720992946 1.3870085883810457 0.2875864020654643 1.0 0.083126337411673 0.1611939416425752 0.0007750266814789 0.0094142249651338 +Endoplasmic reticulum golgi intermediate compartment membrane 6 17 1.9615826288692195 0.0498110963263727 10.49271844660194 25.839805825242717 1.5441023898993702 0.2324243418613106 5.505729177420246 3.7718384126099376 1.49831312620529 0.2965572765953523 1.0 0.2333020504203794 0.0995728547031488 0.1467586347483675 0.2711827902426199 +Intrinsic component of endoplasmic reticulum membrane 14 45 1.9604896475856743 0.0499385868178772 21.439320388349515 53.03155339805825 1.5445183869163015 0.2945609219212759 9.936629672422429 6.151523176643304 2.1054078800196185 0.3580268322643601 1.0 0.4570575797650001 0.0075508250565443 0.0327491618218664 0.0010205904556214 diff --git a/msigdb_gocc/metrics.json b/msigdb_gocc/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..e0b24de421a3fefe05892fbc1c3237e9be1c476c --- /dev/null +++ b/msigdb_gocc/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2454, + "annotations_size": 882, + "title": "Average number of proteins per term", + "value": 23.478458049886623 +} \ No newline at end of file diff --git a/msigdb_gocc/paths.json b/msigdb_gocc/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..922ed0d0f6aea5875a412b305cf2e50e3e5877d5 --- /dev/null +++ b/msigdb_gocc/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gocc/fragment/C340/C340_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gocc/result.tsv b/msigdb_gocc/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..97a1aa162e8d8f09068ccf0d9c4e1460e1bf8694 --- /dev/null +++ b/msigdb_gocc/result.tsv @@ -0,0 +1,227 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Vacuolar lumen 0.6463529946027492 3.863136862061187 0.0001119402496756 0.0940188932464903 0.0679710399230497 54 Q9H7Z7,P06280,P50897,P16278,Q8IV08,P07437,Q8NHP8,Q9BTY2,Q13510,P68371,Q14108,Q99519,P61916,P10619,P17900,P04062,P11117,P10253,O43681 19 +Intrinsic component of organelle membrane 0.5555783863286736 3.7843201085400606 0.0001541293422291 0.1271159564779748 0.0679710399230497 100 O60830,Q8TB61,P10321,Q86XL3,Q99595,Q6ZRP7,O75880,O43808,P42892,Q14739,P57088,P61020,Q16134,Q9Y282,Q9Y679,L0R6Q1,Q5W0Z9,Q13505,Q8IWA4,Q9BWH2,O14925,O75844,Q8N4V1,Q9NX63,Q15041,Q15629,Q9HC21,Q9UM00,Q9UH62,Q15388,Q9UBM7,O75431,O43505,O15118,O95140,Q9UG56,Q9BUN8,P49069,Q9Y4P3,Q5XKP0 40 +Lysosomal lumen 0.7669884873358388 3.576515916050712 0.0003482041253739 0.2644740964036249 0.1023720128599422 30 Q14108,P17900,P61916,Q8IV08,P06280,P04062,P11117,P50897,Q8NHP8,P10619,P16278,Q13510,P10253,O43681,Q99519 15 +Inner mitochondrial membrane protein complex 0.5595008605646141 3.1935536854889257 0.0014053320418421 0.7107241750090831 0.1977967968205764 62 O60830,O75306,O14925,Q9UDW1,P31930,O75964,Q99595,Q9NX63,P00403,P14406,P20674,O43676,Q5XKP0,Q13505,O14949,Q9Y375 16 +Azurophil granule 0.5622303358814614 3.158318668628597 0.0015868199408684 0.7535723409200508 0.1977967968205764 55 P17900,P61916,P11279,O00584,Q9H7Z7,O95721,P42785,P06280,P07437,P10619,Q9BTY2,P16278,P10253,O43681,P68371 15 +Proteasome core complex 0.8064897327358946 2.904972243201195 0.0036728567008292 0.9610479256942536 0.1977967968205764 14 P28070,P28072,P20618,P49721,P60900,Q99436 6 +Intrinsic component of mitochondrial inner membrane 0.6818235250224178 2.7598650010997305 0.0057825251207086 0.993993963488826 0.1977967968205764 23 O60830,O14925,Q9UG56,Q16134,Q99595,Q5XKP0,Q13505 7 +Intrinsic component of mitochondrial membrane 0.6123419831595031 2.7366303630768973 0.0062071995549086 0.9958796290452456 0.1977967968205764 34 Q8IWA4,Q9BWH2,O60830,O75431,O95140,O14925,Q9UG56,Q16134,Q99595,Q9NX63,Q9HC21,O75880,Q15388,Q9UH62,Q5XKP0,Q13505 16 +Mitochondrial protein containing complex 0.4668332792002377 2.7252191660275784 0.0064258816381066 0.996606575681368 0.1977967968205764 128 O60830,Q99595,Q567V2,Q8N4H5,P14406,P21796,P40939,O14949,Q9Y375,Q9NS69,O75306,P31930,Q13505,Q8IWA4,O14925,O75964,Q9NX63,P00403,P20674,O43676,Q9UDW1,Q5XKP0 22 +Organelle inner membrane 0.486379696491169 2.7092189777758495 0.0067441811369912 0.9974419674252506 0.1977967968205764 186 Q9Y619,O60830,Q99595,Q567V2,Q6NUK1,P14406,Q9H061,P40939,O14949,Q9Y375,Q14739,O75306,O43772,P31930,Q9BSK2,Q16134,P23786,Q9H2D1,Q99720,Q13505,O14925,O75964,O75844,Q9NX63,P00403,Q69YU5,O95831,O43676,P20674,Q13185,Q6DKK2,Q70HW3,Q9UDW1,Q9UG56,P22695,Q8NBN7,Q5XKP0,Q9UBX3 38 +Respirasome 0.6120375222904416 2.6528737672573826 0.0079809711883618 0.9991476018578505 0.1997899858469607 32 O75306,Q9UDW1,P31930,P00403,P14406,P20674,O43676,O14949,Q6DKK2,Q9Y375 10 +Azurophil granule lumen 0.5781162543561352 2.5320215731097733 0.0113407013672519 0.9999572289366312 0.217699740984195 35 P17900,P61916,Q9H7Z7,P06280,P07437,P10619,Q9BTY2,P16278,O43681,P68371 10 +Membrane microdomain 0.5097883383073248 2.520680699114181 0.0117128082403077 0.9999693130849872 0.217699740984195 51 P60903,P05067,Q8WTV0,P07437,P50897,P21796,P09601 7 +Outer membrane 0.4703984366199282 2.4526401737491166 0.0141812115154678 0.99999661908484 0.2335749803770448 74 Q8N4H5,P21796,P09601,Q9NS69,P45880,Q8WWV3,Q99720,Q8N0X7,Q13505,Q8IWA4,Q9NX63,O43169,Q9Y277,Q9UH62,Q8WY22,Q9UBM7,O75431,O95140,Q5XKP0 19 +Endoplasmic reticulum 0.4356550952043775 2.4496249325125423 0.0143005090026762 0.9999969613723868 0.2335749803770448 376 P30519,Q06136,P80303,P09601,Q9BQE5,Q5BJF2,Q14739,Q02818,Q9Y282,Q96G23,Q14849,Q9H6V9,Q16850,P07099,O75503,Q13510,O60725,Q14108,P48449,Q9UQB8,O75844,Q8N4V1,Q15629,P10619,P43307,P24390,Q9UBM7,Q9NZ08,O15460,Q9UMX5,P04062,O43852,Q92791,O43681,Q99797,O95197,Q9Y680,O14880,Q86XL3,Q15392,Q15904,Q13501,P05067,Q8IV08,Q9H2J4,Q5W0Z9,P13674,Q14257,Q9BTY2,Q9NWM8,Q99720,P61916,O00584,O75718,Q6UXD5,Q9BUN8,P30626,P51809,Q9Y4P3,Q86YV9,Q01105,Q70UQ0,Q8TB61,Q99523,Q9HD20,Q969V3,P07237,P61923,Q6ZXV5,Q9BRK5,Q9Y217,Q9Y679,O43464,P62820,Q53GQ0,Q15738,O75340,Q15041,O15173,O60506,Q10472,Q9UM00,Q8IXB1,P67812,O15118,P49069 86 +Cytochrome complex 0.7280708501513194 2.439729174947529 0.0146982764054415 0.999997871508653 0.2357069052654441 13 Q9UDW1,P31930,P00403,P14406,P20674,O14949 6 +Proteasome core complex beta subunit complex 0.8630343481895583 2.3269246462379427 0.0199692761892675 0.9999999812324564 0.2752015874833438 7 P28070,P28072,P20618,P49721,Q99436 5 +Vacuole 0.4466358431495604 2.2971429037179427 0.0216106189745919 0.9999999957209612 0.2932394759321551 163 Q86YV9,Q99523,Q9H7Z7,O95721,P42785,P06280,Q9UIQ6,Q8WTV0,P50897,P16278,Q5BJF2,P42892,Q13501,P61421,Q92820,Q8IV08,Q14849,P07437,Q15165,Q8NHP8,Q9BTY2,O75503,Q9UHG3,Q13510,P68371,Q14108,Q99519,P41440,P61916,O00584,Q01085,P10619,Q93050,P17900,P11279,P04062,P11117,P51809,Q9Y487,P10253,O43681 41 +Endoplasmic reticulum lumen 0.4862565603420825 2.260834440504281 0.0237695110424742 0.9999999993901996 0.3102393966901096 50 Q9NZ08,Q02818,O15460,O00584,Q9Y680,P05067,P13674,Q14257,Q9BTY2,Q9NWM8,O43852,O43681 12 +Secretory granule membrane 0.4633829493091044 2.2388557810763214 0.025165301433391 0.9999999998273672 0.3117823701159743 55 P30519,P10321,Q9Y2Q5,O95721,P42785,P49755,O60645,O15439,P20073,P61020,Q6IAA8,Q93050,Q969Q5,P11279,Q92542,P30626,P61106,P51809,P10253 19 +Intrinsic component of golgi membrane 0.7883039954905577 2.2355530153887817 0.0253810652119705 0.9999999998579854 0.3117823701159743 8 O43505,Q8TB61,Q9Y282,Q6ZRP7,Q5W0Z9 5 +Vesicle lumen 0.4129020972658629 2.2217492062379804 0.0263002591328755 0.9999999999382128 0.3117823701159743 102 P17900,Q99519,P61916,O00584,Q9H7Z7,P20618,P05067,P06280,O75874,P07437,Q8NBX0,P10619,Q9BTY2,P16278,Q08380,O43681,P68371 17 +Early endosome 0.4488303252151227 2.198392247575855 0.0279211656747675 0.999999999985786 0.3240324753308549 71 Q86YV9,P61421,P41440,Q99523,Q5VW38,P05067,P61020,Q9BUN8,Q8IV08,Q9UIQ6,Q8N4V1,P31751,P62820,P04083,Q99816,Q13510,Q9Y2I1 17 +Outer mitochondrial membrane protein complex 0.6408088878876285 2.1690626688890897 0.0300779263929564 0.999999999997996 0.3321001216637968 16 Q8IWA4,Q8N4H5,Q5XKP0,Q9NS69,Q13505 5 +Pore complex 0.7689874213255904 2.1487246790044177 0.0316562311788146 0.9999999999995236 0.3379516384137162 8 P21796 1 +Nuclear inner membrane 0.6365735055619707 2.144760865923057 0.0319719716190567 0.9999999999996426 0.3379516384137162 16 Q99720,O75844,Q13185,Q14739 4 +Endocytic vesicle membrane 0.5411725212645101 2.111480763240557 0.0347310096678414 0.9999999999999712 0.3480994378072294 31 P61421,Q14108,P11279,Q8WTV0,Q93050,Q9Y487 6 +Tim23 mitochondrial import inner membrane translocase complex 0.8608506909905418 2.0966335761906714 0.0360260246450101 0.9999999999999912 0.3523129818948517 6 O60830,Q99595 2 +Caveola 0.6746290096697393 2.043771225535058 0.0409761530526 1.0 0.374138071291342 12 Q8WTV0,P09601 2 +Cell surface 0.4384480603076301 2.0247777034674916 0.0428901955521385 1.0 0.3821126512826891 62 P41440,P11279,Q99523,P05067,O96005,O43847,Q8WTV0,P08183,P07237,P04083,Q9Y639,P11233,O15439,Q9UII2,P42892 15 +External side of apical plasma membrane 0.9384176182707996 2.0194604273797863 0.043439386376558 1.0 0.3831353878412423 2 P08183 1 +Proton transporting two sector atpase complex proton transporting domain 0.7245393697368127 2.01233302058255 0.0441848438407059 1.0 0.3858518046287393 9 P61421,O75947,O75964,P56134,Q93050,Q9Y487 6 +Respiratory chain complex iv 0.7160324436415635 1.972279801594907 0.0485776741071377 1.0 0.4065653560124058 9 P00403,P14406,P20674 3 +Endoplasmic reticulum golgi intermediate compartment membrane 0.5933351355568103 1.9615826288692195 0.0498110963263727 1.0 0.4065653560124058 17 Q9Y3B3,Q9Y282,P49755,Q10472,P24390,Q15904 6 +Intrinsic component of endoplasmic reticulum membrane 0.4737950088001573 1.9604896475856743 0.0499385868178772 1.0 0.4065653560124058 45 P10321,Q8TB61,Q9BUN8,P49069,Q9Y282,Q86XL3,Q9Y679,Q15041,Q8N4V1,O75844,Q15629,Q9Y4P3,Q9UM00,Q9UBM7 14 +Platelet dense granule 0.9237357259380108 1.9578767947243012 0.0502444714346397 1.0 0.4065653560124058 2 O15439 1 +Azurophil granule membrane 0.5911049476768485 1.9481175880688544 0.0514008947722397 1.0 0.4084287314334726 17 P42785,P11279,P10253,O95721 4 +Mitochondrion 0.3200028147081556 1.934959303894364 0.0529952898364047 1.0 0.4102199962094138 495 Q9Y619,O60830,P28070,Q9NR28,Q9H773,Q9H7Z7,Q3SXM5,Q16740,Q99595,Q567V2,Q8N4H5,Q9NR77,P14406,P21796,Q9H061,P09601,P40939,P48735,Q15120,O14949,Q9NS69,Q9Y375,P45880,Q13501,O75306,O43772,O15382,P31930,Q9BSK2,Q16134,O75874,Q14849,P23786,Q8WWV3,Q15165,Q8NBX0,P13674,P11233,Q9H2D1,Q13505,Q8IWA4,P13804,O00584,O14925,P30837,O75964,O43847,Q9NX63,O43169,P00374,P00403,Q16836,Q69YU5,O95831,O43676,Q9NUJ1,P16219,P20674,Q8WY22,Q96EK5,Q6DKK2,Q9UII2,Q70HW3,Q9UDW1,Q9UG56,Q9UMX5,P22695,Q86W56,Q8NBN7,Q5XKP0,O75648,Q9H0R6,Q99797 73 +Intraciliary transport particle b 0.9115008156606864 1.9063597709474949 0.0566035443435208 1.0 0.4230875094151307 2 A0AVF1 1 +Autolysosome 0.9082381729200666 1.8925928840313624 0.0584120308170237 1.0 0.4232567275548995 2 Q13501 1 +Secondary lysosome 0.9082381729200666 1.8925928840313624 0.0584120308170237 1.0 0.4232567275548995 2 Q13501 1 +Plasma membrane raft 0.592468917175227 1.8875015063181677 0.0590929039333372 1.0 0.423739359912223 16 Q8WTV0,P09601 2 +Phagocytic vesicle membrane 0.5741733808269351 1.8785935642516352 0.0603000105866184 1.0 0.4274101369105174 18 P61421,Q9Y487,P11279,Q93050 4 +Lipid droplet 0.5121339466133502 1.841022023685313 0.0656183313372364 1.0 0.4521513143706452 29 Q01105,P48449,Q9Y679,Q8NBX0,Q9H6V9,Q99720,Q8N0X7 7 +Endosome lumen 0.8463288085543177 1.8179022928609951 0.069079067818587 1.0 0.4621660882573855 4 Q9UIQ6 1 +Compact myelin 0.8817292006525239 1.780316383665273 0.0750241973314904 1.0 0.4761716525704297 2 Q9NR77 1 +Oxidoreductase complex 0.4501613068899836 1.7802018984092856 0.0750429248381969 1.0 0.4761716525704297 46 O75306,P13804,Q9UDW1,P31930,P22695,O43169,P13674,O43676,O14949,Q9Y375 10 +External side of plasma membrane 0.5508758985389561 1.7671790306607058 0.0771982503233505 1.0 0.4766465230973728 19 P41440,P11279,O96005,P08183,P07237,P04083,O15439 7 +Cd40 receptor complex 0.8768352365415932 1.7595123686927796 0.0784905212765476 1.0 0.4807544428188544 2 Q9NR28 1 +Endoplasmic reticulum golgi intermediate compartment 0.4706943689848952 1.753772567578598 0.0794694853745514 1.0 0.4819435304875412 38 Q02818,P80303,Q9Y217,Q9Y282,P07237,P24390,Q15904 7 +Dendritic shaft 0.7993119524825216 1.751046087376684 0.0799379716545387 1.0 0.4819435304875412 5 Q9UQB8,Q14168 2 +Golgi lumen 0.8287780993710494 1.7467518469857335 0.0806803925970527 1.0 0.4819435304875412 4 O00461,P05067 2 +Nuclear outer membrane endoplasmic reticulum membrane network 0.4201139452353384 1.730864524585028 0.0834759301980319 1.0 0.4843800686491061 238 P30519,O95197,Q70UQ0,Q8TB61,Q06136,Q99523,Q9HD20,O14880,Q969V3,Q86XL3,P61923,P09601,Q9BQE5,Q5BJF2,Q15392,Q15904,Q14739,Q9Y282,Q96G23,Q8IV08,Q14849,Q9Y679,O43464,Q53GQ0,Q16850,P07099,O60725,Q99720,Q14108,Q15738,O75340,P48449,Q6UXD5,O75844,Q8N4V1,Q15041,Q15629,Q10472,Q9UM00,P43307,P24390,Q9UBM7,P67812,Q9NZ08,Q9BUN8,P49069,P30626,P51809,Q9Y4P3,O43852 50 +Proton transporting v type atpase v0 domain 0.9355365157078754 1.7094421774348316 0.0873690738372252 1.0 0.4907944620811166 3 Q93050,Q9Y487 2 +Vacuolar proton transporting v type atpase v0 domain 0.9355365157078754 1.7094421774348316 0.0873690738372252 1.0 0.4907944620811166 3 Q93050,Q9Y487 2 +Er ubiquitin ligase complex 0.8195918367346926 1.7093594551337243 0.0873843863802938 1.0 0.4907944620811166 4 Q9Y679,Q9BUN8,Q9UBU6 3 +Intrinsic component of mitochondrial outer membrane 0.6604898256432745 1.7064727461758362 0.087920096381878 1.0 0.4907944620811166 9 Q8IWA4,O95140,Q9UH62,Q9BWH2 4 +Lewy body 0.8535889070146756 1.6604149228866574 0.0968310101028508 1.0 0.5216948318419028 2 Q13501 1 +Nucleoid 0.4915400915762832 1.6434799651998555 0.1002836672281346 1.0 0.5262951015056074 27 P45880,P21796 2 +Mitochondrial envelope 0.41334797175372 1.6313430683564218 0.1028179505061197 1.0 0.5276734526139977 241 Q9UJS0,O60830,Q99595,Q567V2,P14406,P21796,Q9Y2R0,P09601,Q10713,Q9NS69,P36542,P45880,O43772,O00264,Q9BSK2,Q16134,Q16795,Q9H2W6,Q8WWV3,Q9Y512,P82650,Q9H2D1,Q13505,O75964,O43169,Q69YU5,O95831,O43676,Q6DKK2,Q9UDW1,Q9UG56,Q5XKP0,Q9Y619,Q9NR28,Q8N4H5,Q9H061,P40939,O14949,Q9Y375,O75306,P31930,P23786,Q8IWA4,O00584,O14925,Q9NX63,P00403,P20674,Q8WY22,Q70HW3,P22695,Q8NBN7,Q9UBX3,Q6NUK1,O43464,Q02978,Q8N0X7,Q9Y277,Q9UH62,O75431,O95140,Q5VT66,Q9P032,Q8N183,Q13423,O75880,Q9UJZ1,O75947,Q99536,Q96IX5,Q96BR5,Q15785,Q9BWH2,Q8IUX1,P56134,Q9HC21,Q15388,P12235,Q9BRJ2,Q9NPL8,Q92552,P24539,Q96A26,Q96AY3 84 +Respiratory chain complex iii 0.7704591812751138 1.6309431962869283 0.102902305951936 1.0 0.5276734526139977 5 O14949,Q9UDW1,P31930 3 +Multivesicular body 0.6389404791468419 1.6014465587781674 0.1092780475790076 1.0 0.5475171442202091 9 P11279,Q8WUX9,Q99816,P10644,P13693 5 +Vacuolar membrane 0.3757584004087298 1.5987512300140512 0.1098758894863685 1.0 0.5475171442202091 92 Q86YV9,O95721,P42785,Q9UIQ6,Q8WTV0,P61421,Q8IV08,Q14849,O75503,Q99519,Q14108,P41440,P10619,Q93050,P11279,P04062,P11117,P51809,Q9Y487,P10253 20 +Ragulator complex 0.822593800978793 1.527724486366383 0.126580957893001 1.0 0.5848637590973137 2 Q9Y2Q5 1 +Ccr4 not complex 0.679551807786432 1.527429803763326 0.1266541700539534 1.0 0.5848637590973137 7 Q9H9A5,Q92600,Q9UIV1 3 +Cis golgi network 0.6297660954462794 1.4976551390731463 0.1342228729359882 1.0 0.604002928211947 8 P24390,O00461 2 +Micos complex 0.7554991560456584 1.446051999229658 0.1481626175687829 1.0 0.6348026519934776 4 Q5XKP0 1 +Brush border membrane 0.7043127884592264 1.4424569953974469 0.1491734950659662 1.0 0.6348026519934776 6 Q9UHB6 1 +Organelle membrane contact site 0.5440396443228602 1.4388159645406604 0.1502026719609284 1.0 0.6348026519934776 13 Q14849 1 +Exocytic vesicle 0.4573977076389718 1.4094504124356622 0.1587020263636613 1.0 0.6450469458652043 28 P61421,P50897,P05067,P61020 4 +Glial cell projection 0.7171066502419436 1.406360577475027 0.1596170803402778 1.0 0.6457902057803904 5 Q8IXJ6,P05067 2 +Gamma secretase complex 0.7858890701468184 1.3702043669142827 0.1706231155227713 1.0 0.657184210582663 2 Q92542 1 +Nuclear envelope lumen 0.7067605547630004 1.362530061503013 0.173030663714953 1.0 0.657184210582663 5 P07437 1 +Proton transporting v type atpase complex 0.5898253045347839 1.3586959832160277 0.1742429454726906 1.0 0.657184210582663 9 Q93050,Q9Y487,Q15904 3 +Tertiary granule 0.4315461345035847 1.3490130240747304 0.1773327827972011 1.0 0.657184210582663 34 P42785,Q13510,Q93050,O75874 4 +Side of membrane 0.3759402912096061 1.341066050400094 0.1798990086620862 1.0 0.657184210582663 54 P41440,P17900,Q9NR28,P11279,P04899,O96005,P08183,P07237,O43464,P04083,P10619,O15439,P42892 13 +Chromaffin granule membrane 0.7781402936378403 1.336959789311049 0.1812357626905356 1.0 0.657184210582663 2 P30626 1 +Chromaffin granule 0.7781402936378403 1.336959789311049 0.1812357626905356 1.0 0.657184210582663 2 P30626 1 +Postsynaptic density membrane 0.6372342637810903 1.3348417132832948 0.1819281578323925 1.0 0.657184210582663 7 Q14168,Q99720 2 +Cytolytic granule 0.8301610600076443 1.301597440145403 0.1930540353644274 1.0 0.6598998758773686 3 Q01085 1 +Ciliary transition zone 0.6865816303706735 1.276890032780828 0.2016410735156082 1.0 0.6598998758773686 5 A6NIH7 1 +Ficolin 1 rich granule membrane 0.4918531401729214 1.273692859689735 0.2027722879632618 1.0 0.6598998758773686 16 P42785,Q93050,P10253 3 +Postsynaptic specialization membrane 0.5724855889095783 1.2721015016947983 0.2033370577054067 1.0 0.6598998758773686 9 Q14168,Q99720 2 +Golgi cisterna membrane 0.5720600214685602 1.2699718665385926 0.2040946516836341 1.0 0.6598998758773686 9 Q10472,O00461,Q99523 3 +Juxtaparanode region of axon 0.8207809049688433 1.2652178208818303 0.2057932558711444 1.0 0.6598998758773686 3 Q14168 1 +Hrd1p ubiquitin ligase erad l complex 0.8192574459404364 1.25931211368322 0.2079176195045833 1.0 0.6598998758773686 3 Q9Y679,Q9BUN8 2 +Proton transporting two sector atpase complex 0.4721718858597602 1.254398532668666 0.2096971856314522 1.0 0.6598998758773686 19 P61421,O75947,O75964,P56134,Q96IX5,P24539,Q93050,Q9Y487,Q15904 9 +Paraspeckles 0.6580148289412837 1.2431274036321096 0.2138208890056492 1.0 0.6673626556166687 6 Q8WXF1,P23246,Q15233,Q16630 4 +Golgi membrane 0.3454018220255204 1.2175184089864206 0.2234070366219844 1.0 0.6817045695100037 92 O95197,Q9Y3B3,Q8TB61,P10321,Q9H7Z7,O95721,Q8NCH0,Q6ZRP7,P49755,P61923,Q10713,Q15392,P08754,Q9Y282,Q8IV08,L0R6Q1,Q5W0Z9,P62820,Q14108,Q8N4V1,Q10472,Q8N6T3,Q9UM00,Q9BW83,P24390,O43505,Q9H8Y8,O00461,P61106,P40616 30 +Nadh dehydrogenase complex 0.4822461002927083 1.2134802475012345 0.2249462618232183 1.0 0.6817045695100037 16 Q9Y375,O43676 2 +Endocytic vesicle 0.3609011656405356 1.2114493931530457 0.2257232188968467 1.0 0.6817045695100037 67 P61421,Q14108,P11279,P61020,O00461,Q8WTV0,P11233,Q93050,Q9Y487 9 +Proteasome complex 0.3918605771495975 1.2095230819698606 0.2264619488281531 1.0 0.6817045695100037 45 P28070,P04792,P28072,P49721,P20618,P60900,Q99436,P28074 8 +Mib complex 0.5468946349040822 1.196839683881035 0.2313690473213345 1.0 0.691754236398024 10 Q13505,Q9NX63,Q5XKP0 3 +Proton transporting atp synthase complex coupling factor f o 0.6446532536573898 1.1854090926582896 0.235855738393143 1.0 0.6934158708758404 6 O75947,P56134,O75964 3 +Peptidase complex 0.3603191945970274 1.1745866333824373 0.2401601335119987 1.0 0.6980921870199813 55 P28070,P04792,P28072,P49721,P20618,P60900,O43464,Q99436,P28074,P67812 10 +Dna replication factor c complex 0.6414306237312147 1.1714853058664016 0.2414037608175672 1.0 0.6980921870199813 6 P35250 1 +Organelle subcompartment 0.382750336534276 1.1645015997723462 0.2442207954121633 1.0 0.6993595504984678 278 P30519,O95197,Q70UQ0,Q8TB61,Q06136,Q99523,Q9HD20,O14880,Q969V3,Q86XL3,P61923,P09601,Q9BQE5,Q5BJF2,Q15392,Q15904,Q14739,P05067,Q9Y282,Q96G23,Q8IV08,Q14849,Q9Y679,O43464,Q53GQ0,Q16850,P07099,O60725,Q99720,Q14108,Q15738,O75340,P48449,Q6UXD5,O75844,Q8N4V1,Q15041,Q15629,Q10472,Q9UM00,P43307,P24390,Q9UBM7,P67812,Q9NZ08,Q9NPR9,Q9BUN8,P49069,Q9H8Y8,P30626,O00461,P04062,P51809,Q9Y4P3,P40616,O43852 56 +Secretory vesicle 0.3726472305221527 1.1249604350295916 0.260605800433187 1.0 0.7101143967727126 207 P30519,Q9H7Z7,O95721,P42785,P06280,P50897,P16278,O15439,P45880,P61421,P05067,P61020,O75874,P07437,Q8NBX0,Q9BTY2,Q13510,Q08380,P68371,Q99519,P61916,O00584,Q9UQB8,Q9NTK5,P10619,Q93050,P17900,P11279,P20618,P30626,Q9Y487,P10253,O43681 33 +Messenger ribonucleoprotein complex 0.6492433311675733 1.1182996460161114 0.2634390380685787 1.0 0.7101143967727126 5 P51991,Q99729 2 +Tertiary granule lumen 0.4766139849595281 1.0872094548318962 0.2769442532726744 1.0 0.7101143967727126 14 O75874 1 +Er membrane insertion complex 0.7743245925629482 1.0858088377692028 0.2775635755488206 1.0 0.7101143967727126 3 P46379 1 +Proton transporting atp synthase complex 0.5249297003077263 1.0836718817103692 0.2785103070714614 1.0 0.7101143967727126 10 O75947,P56134,O75964,Q96IX5,P24539 5 +Main axon 0.5800059709752955 1.0722315786060306 0.2836160299574999 1.0 0.7101143967727126 7 Q14168,P05067 2 +Secretory granule 0.3640430944288019 1.068289670659163 0.2853898664233418 1.0 0.7101143967727126 190 P30519,Q9H7Z7,O95721,P42785,P06280,P16278,O15439,P45880,P05067,P61020,O75874,P07437,Q8NBX0,Q9BTY2,Q13510,Q08380,P68371,Q99519,P61916,O00584,Q9UQB8,Q9NTK5,P10619,Q93050,P17900,P11279,P20618,P30626,Q9Y487,P10253,O43681 31 +Endopeptidase complex 0.3633675796814927 1.0666723702087555 0.2861198079625697 1.0 0.7101143967727126 50 P28070,P04792,P28072,P49721,P20618,P60900,O43464,Q99436,P28074 9 +Escrt iii complex 0.7141109298531847 1.064030147362307 0.2873150426825583 1.0 0.7101143967727126 2 Q8WUX9 1 +Amphisome membrane 0.7141109298531847 1.064030147362307 0.2873150426825583 1.0 0.7101143967727126 2 Q8WUX9 1 +Multivesicular body membrane 0.7141109298531847 1.064030147362307 0.2873150426825583 1.0 0.7101143967727126 2 Q8WUX9 1 +Ficolin 1 rich granule 0.3437200209693852 1.0639099268067689 0.2873695056266854 1.0 0.7101143967727126 77 P20618,P42785,O75874,P16278,Q93050,Q13510 6 +Cornified envelope 0.6357697019191391 1.0611976786750494 0.2886000741232455 1.0 0.7101143967727126 5 P04083,P04080,P14923,P15924 4 +Specific granule 0.4156429961839921 1.0479596757002156 0.2946571858840845 1.0 0.7120209258897604 25 P30519,O00264,Q9Y2Q5,Q9BS26,Q92820,Q6IAA8,Q99519 7 +Blood microparticle 0.458277574722173 1.0177019520063193 0.308819619341935 1.0 0.7234939182894978 15 P04062,P07737 2 +Mitochondrial proton transporting atp synthase complex coupling factor f o 0.6242034285996296 1.0123067808847657 0.3113913936908514 1.0 0.7234939182894978 5 O75947,O75964 2 +Platelet alpha granule 0.462136943563579 1.0006432027069612 0.3169993355185163 1.0 0.7300089136483848 14 Q8NBX0,Q9NTK5,P05067 3 +Neuronal ribonucleoprotein granule 0.7429620563035563 0.96609954168215 0.333994373860734 1.0 0.7498226426951324 3 Q99729,Q06787 2 +Autophagosome 0.432336509506915 0.9649261421240936 0.3345818064744508 1.0 0.7498226426951324 18 Q969Q5,Q13501,P11279,Q96AX1,O95721,Q9Y679,Q8WUX9,Q9Y3E7,Q9P253 9 +Cop9 signalosome 0.5102827859990389 0.9599792034146738 0.3370656817241808 1.0 0.7526378007107025 9 Q99627,P62993,Q9BT78 3 +Early endosome membrane 0.3883049241493281 0.944796958357988 0.3447625450297833 1.0 0.7602014117906721 32 Q86YV9,P61020,Q8IV08,Q8N4V1,P04083,Q99816,Q96J02 7 +Dynactin complex 0.6045084794856047 0.9294628314471932 0.3526492789369762 1.0 0.7661001576906724 5 P61163 1 +Nuclear cyclin dependent protein kinase holoenzyme complex 0.6794453507340978 0.91920267072849 0.3579895744742973 1.0 0.7689156392850591 2 Q9P287 1 +Prefoldin complex 0.6245962828708637 0.9056913889468148 0.3650992215621638 1.0 0.7740805611005491 4 Q99471 1 +Basal part of cell 0.3688293294457766 0.8648856305546339 0.3871015652096243 1.0 0.7844549126164714 37 P42785,P41440,Q14168,O15439 4 +Envelope 0.3426328450335695 0.8617896709685832 0.3888032698836732 1.0 0.7844549126164714 384 Q9Y619,O60830,Q9NR28,Q99523,P80303,O14880,Q99595,Q567V2,Q6ZRP7,Q6NUK1,Q8N4H5,P14406,P21796,Q9H061,P09601,P40939,Q9H1E5,Q5BJF2,O14949,P37198,Q9NS69,Q14739,P45880,Q9Y375,O75306,O43772,P05067,P31930,Q9BSK2,Q16134,Q9Y217,Q8NFH4,P07437,Q8WWV3,P23786,O43464,Q9H2D1,Q99720,Q13505,Q9UI26,Q8IWA4,O00584,O14925,O75964,O75844,Q9NX63,O43169,P00403,Q69YU5,O95831,O43676,P20674,Q13185,Q8WY22,Q9UBM7,Q9UJC5,Q6DKK2,Q70HW3,Q9UDW1,Q9UG56,P22695,Q8NBN7,Q5XKP0,Q9UBX3,Q9BTX1 65 +Amphisome 0.7144022847817313 0.8588040242498417 0.3904486469825696 1.0 0.7844549126164714 3 Q8WUX9,Q13501 2 +Escrt complex 0.7144022847817288 0.8588040242498324 0.3904486469825747 1.0 0.7844549126164714 3 Q8WUX9,Q99816 2 +Platelet alpha granule lumen 0.4881645655379714 0.849532771178905 0.3955849029261586 1.0 0.7869281491157255 9 Q8NBX0,P05067 2 +Cleavage furrow 0.4676164021081002 0.8493889494630769 0.3956649000929146 1.0 0.7869281491157255 11 P11233,Q9UHB6 2 +Signal peptidase complex 0.7118221144698362 0.849215290346684 0.3957615065785496 1.0 0.7869281491157255 3 P67812 1 +Basement membrane 0.6598694942903753 0.8390381908243019 0.4014478788408622 1.0 0.7893294230412303 2 Q03001 1 +Nuclear pore central transport channel 0.6062156500349325 0.8315206121454736 0.4056795889739417 1.0 0.7933689522727642 4 P37198 1 +Clathrin coated endocytic vesicle membrane 0.4609917777290822 0.814185186192455 0.4155388705924669 1.0 0.7936523516224643 11 Q14108 1 +Organelle envelope lumen 0.3699187519282305 0.8132323382283083 0.4160848618788995 1.0 0.7936523516224643 33 Q9NR28,O00584,O14925,P05067,P07437,O43464,Q96BR5,O95831,Q9HB71,Q9UJZ1 10 +Endoplasmic reticulum tubular network membrane 0.6529363784665534 0.8110058963837495 0.4173622846299958 1.0 0.7936523516224643 2 Q9NQC3 1 +Presynapse 0.3235914401460497 0.8082327474029563 0.4189566093992689 1.0 0.7936523516224643 74 O95721,P50897,O60645,Q9Y639,P61421,P05067,P61020,Q96CX2,P41440,Q9UQB8,Q13363,Q9BT78,O43760,P11279,Q92542,P35080,O75494,Q06787,Q07021 19 +Transport vesicle 0.324625982291643 0.8053226585812777 0.4206335096441069 1.0 0.7936523516224643 70 Q9Y3B3,P10321,Q99523,P50897,P61923,Q9NR31,P61421,P05067,P61020,P62820,O75340,Q9BT78,P24390,O43760,P11279,Q92542,O00461,P61106,P51809,Q92572 20 +Neurofibrillary tangle 0.647634584013053 0.7897123419027448 0.4296957819179912 1.0 0.7937571571072892 2 P07197 1 +Snare complex 0.4654329447837779 0.7784457702186554 0.4363062648382143 1.0 0.7967331792697826 10 O95721 1 +Lamellar body 0.6366231647634633 0.7459177606758073 0.455717095657224 1.0 0.8088994474205075 2 P51149 1 +Golgi cisterna 0.4480742798056301 0.7458938994347099 0.4557315107580391 1.0 0.8088994474205075 11 Q10472,O00461,Q99523 3 +Intrinsic component of plasma membrane 0.3206068881339603 0.7403725755506567 0.4590739546375644 1.0 0.8126378445772537 57 P41440,P11279,Q9NR28,O43657,P05067,O43813,O96005,Q9UIQ6,Q9H2J7,Q8WTV0,O43464,Q02978,Q9Y639,Q99797 14 +Myelin sheath 0.4728357713269997 0.7344014948246852 0.4627040760216572 1.0 0.8145808284453128 8 Q9NR77 1 +Lumenal side of membrane 0.4640625834575828 0.7304942573462181 0.4650881219254397 1.0 0.8155223131972918 9 P10619 1 +Gtpase complex 0.6771062613093392 0.7223634154826346 0.470071073432708 1.0 0.8168215076285663 3 P04899 1 +Nuclear exosome rnase complex 0.4997605509071732 0.7085448066073423 0.4786069975491769 1.0 0.8228681712249006 7 Q15024,Q9Y3B2,Q9Y2L1 3 +Schaffer collateral ca1 synapse 0.4103582561938286 0.6927524818752125 0.488464897323702 1.0 0.8356548226924094 14 Q9BVA1 1 +Copii coated er to golgi transport vesicle 0.3729357907787443 0.6741103799232852 0.5002411408147553 1.0 0.8367813664691665 23 Q9Y3B3,O75340,P10321,P05067,Q9Y282,Q9NR31 6 +Transcription factor tfiid complex 0.5649156625227767 0.6690336045713209 0.5034740418071499 1.0 0.8367813664691665 4 P18074 1 +Autophagosome membrane 0.4899698180308414 0.6654410440989488 0.5057684402604181 1.0 0.8367813664691665 7 P11279,O95721 2 +Endosome 0.3201640034036844 0.6602568934316918 0.5090889877119891 1.0 0.8367813664691665 151 Q86YV9,P10321,Q99523,Q9Y2Q5,Q9UIQ6,P31751,Q15904,P42892,Q13501,P61421,Q5VW38,P05067,Q9BRK5,P61020,Q8IV08,Q14849,P62820,Q99816,Q13510,P62993,Q14108,P41440,O75340,Q8N4V1,P04083,Q96J02,Q93050,P11279,O15118,Q9BUN8,O00461,P51809,P13693,Q9Y487,Q9Y2I1 35 +Membrane protein complex 0.3453120468368186 0.6579312054295291 0.5105823377547796 1.0 0.8367813664691665 228 Q9Y3B3,O60830,Q9NR28,P10321,Q9Y2Q5,O95721,Q99595,P49755,Q8N4H5,P61923,P14406,Q9Y5M8,P21796,O14949,Q15904,Q9NS69,P36542,P45880,Q9Y375,P08754,O75306,P60903,P61421,Q9NR31,P31930,Q16795,Q9Y679,O75947,O43464,Q9UBU6,Q9Y512,Q96IX5,Q53GQ0,Q6IAA8,Q99816,O60493,P62993,P17612,Q9UBV2,Q13505,Q9NVZ3,Q8IWA4,P41440,O75340,Q8NC96,O14925,Q96S52,O75964,P56134,Q15041,P14923,Q8N4V1,Q03519,Q9NX63,P00403,P20674,Q9Y277,O43676,Q15388,Q93050,P12235,Q9C0H2,O75431,P67812,Q9UDW1,Q9BUN8,Q92542,P22695,Q8WUX9,P51809,Q92572,P24539,Q5XKP0,P04899,Q9Y487,Q96CS3 76 +Smooth endoplasmic reticulum 0.4485930020154298 0.6552370828219317 0.5123151223280611 1.0 0.8367813664691665 9 Q13217,O00264,P05067 3 +Cytoplasmic ubiquitin ligase complex 0.5139437494137171 0.6312221239634921 0.5278952980693581 1.0 0.8511949778741752 6 Q9Y679,Q9BUN8,Q9UBU6 3 +Early phagosome 0.6446348429212594 0.6083375615822838 0.5429636136457805 1.0 0.860111813975103 3 O60493,Q06481 2 +Kinetochore microtubule 0.5078109521813662 0.6064996935183655 0.5441829858052984 1.0 0.860111813975103 6 P50748,Q8WUX9,Q9Y3E7 3 +Guanyl nucleotide exchange factor complex 0.6374166646843211 0.5837488118106019 0.5593893217880024 1.0 0.8716985544470285 3 Q9Y2Q5 1 +Apical plasma membrane 0.3311985334641479 0.5323441439324383 0.5944876634075011 1.0 0.8885627761554843 36 P61421,P41440,P08183,O15439,Q99797 5 +Endoplasmic reticulum chaperone complex 0.487716262663618 0.5270409692197671 0.5981651382983433 1.0 0.8885627761554843 6 P07237 1 +Chromocenter 0.5042724109267454 0.5264245693779107 0.5985932485576793 1.0 0.8885627761554843 5 P45973,P83916 2 +Camp dependent protein kinase complex 0.6167029179526213 0.5149928797065978 0.6065579956089922 1.0 0.8931288015477981 3 P10644 1 +Golgi stack 0.3632426119774394 0.5009487909065452 0.6164071632313688 1.0 0.8999770532423222 17 Q9UNZ2,Q99523,O00461,P61106,Q10472 5 +Trna methyltransferase complex 0.5160061167065237 0.4881182190979513 0.6254661068740424 1.0 0.9043624692834514 4 P57081 1 +Endoplasmic reticulum protein containing complex 0.2966438446252006 0.4782059655677653 0.6325036169664879 1.0 0.9100623004313906 56 Q96CS3,Q9BUN8,P49069,Q96S52,Q9Y679,Q15041,Q8N4V1,Q9UBU6,P07237,Q6NUQ1,P13674,Q9Y5M8,Q53GQ0,Q8IXB1,Q9UBV2,O43681,P67812 17 +Golgi transport complex 0.5546492659053928 0.4452935955848411 0.6561075955338425 1.0 0.9231393714889058 2 P60953 1 +Derlin 1 retrotranslocation complex 0.5036328456677166 0.445102979797172 0.6562453355142222 1.0 0.9231393714889058 4 Q9BUN8 1 +Perinuclear region of cytoplasm 0.3019972154672391 0.4378390974537585 0.6615029267521992 1.0 0.925097958020322 146 Q01105,Q99523,Q9H7Z7,Q9UIQ6,P16278,P09601,P42892,Q8IXJ6,P05067,Q9Y217,Q9H2J4,Q5W0Z9,O75503,O75340,Q10472,O95831,Q93050,P11279,Q15056,O94788,O75935,Q9Y487 22 +Phagocytic vesicle 0.3217332124403243 0.4329267367458447 0.6650679954095313 1.0 0.925097958020322 34 Q9UNK0,P61421,P11279,P10321,P08670,P61106,P51809,Q03519,O60493,Q9Y487,Q93050 11 +Neuron projection terminus 0.3676429537060228 0.4287914205050365 0.6680750230585952 1.0 0.925097958020322 13 Q9UQB8 1 +Extrinsic component of mitochondrial inner membrane 0.5489396411093052 0.4265417750662865 0.6697131143816257 1.0 0.925097958020322 2 Q96BW9 1 +Clathrin coated endocytic vesicle 0.3633318106407922 0.4239694085643634 0.671588123561611 1.0 0.925097958020322 14 Q14108 1 +Ficolin 1 rich granule lumen 0.2911710226268768 0.4131933035479568 0.679464993942859 1.0 0.9252383813186922 61 Q13510,O75874,P16278 3 +Synaptic vesicle membrane 0.390408357865244 0.4130317278796925 0.6795833681955252 1.0 0.9252383813186922 10 Q86Y82,P20339,O00429,P61020,P51149,O76024,O43760 7 +External encapsulating structure 0.3368281261751248 0.4031943821231299 0.6868052321742804 1.0 0.9276603595370831 22 P20073,P60903,Q32P28,Q03001,P04083,Q53GQ0,Q08380 7 +Phagophore assembly site membrane 0.578947368421057 0.3977779205114211 0.6907938940509297 1.0 0.9287808148672562 3 P51149,Q9H0U4 2 +Tubular endosome 0.5774408202695626 0.3933486213266688 0.6940620117145699 1.0 0.9313848477358556 3 O75436 1 +Coated vesicle 0.2891239957430657 0.3918167987734386 0.6951935818971104 1.0 0.9313848477358556 69 Q14108,Q9Y3B3,Q8NC96,P10321,Q99523,Q5VW38,P05067,Q9NVZ3,O75340,Q9Y282,P61106,P51809,P61923,P24390,P42892,Q9NR31 16 +Microbody membrane 0.3451741870769876 0.3903962721126106 0.6962435440365708 1.0 0.9313848477358556 17 Q9NR77,O43808,Q15067,P51648,Q99614 5 +Neuromuscular junction 0.3507432730289747 0.3745222462357234 0.7080158088129433 1.0 0.9376425576171412 15 Q14168,O43760,P05067,P10644 4 +Sarcolemma 0.3303618454914083 0.360435231512774 0.7185216837144064 1.0 0.942459968684084 22 P41440,P11279,P04083 3 +Ciliary tip 0.4553974106671852 0.3525917898817494 0.7243944935100146 1.0 0.942577560097534 5 Q9BW83,A0AVF1 2 +Intrinsic component of presynaptic membrane 0.4553283412569895 0.3523624969814471 0.7245664237484446 1.0 0.942577560097534 5 Q9Y639 1 +Mcrd mediated mrna stability complex 0.4725978729599279 0.3435085049715738 0.731215943617106 1.0 0.9489101158870896 4 O60506 1 +Eukaryotic translation initiation factor 3 complex 0.3471942060864408 0.3368568491279125 0.7362248154816937 1.0 0.9489101158870896 14 Q92905,P60228,O15372,Q9Y262,Q7L2H7,P56537 6 +Vesicle membrane 0.3094048364350354 0.3285808041637905 0.74247255920035 1.0 0.9496788140165932 181 P30519,Q86YV9,Q9Y3B3,P10321,Q99523,Q9Y2Q5,O95721,P42785,Q9UIQ6,P49755,Q8WTV0,P61923,O60645,O15439,Q15904,P42892,Q9NR31,P61421,P61020,Q8IV08,Q14849,P62820,Q6IAA8,P11233,Q99816,P62993,Q9NVZ3,Q14108,O75340,Q8NC96,O14828,Q8N4V1,P04083,Q96J02,Q93050,P55011,P24390,O43760,Q969Q5,P11279,O15118,Q92542,P30626,O00461,P61106,P51809,Q8WUX9,Q92572,Q9Y487,P10253 50 +Collagen containing extracellular matrix 0.3293507510791697 0.3262185967846505 0.7442589721488138 1.0 0.9496788140165932 20 P20073,P60903,Q32P28,Q03001,P04083,Q08380 6 +Hops complex 0.465638852695067 0.3221206778474284 0.747361273827114 1.0 0.9496788140165932 4 Q96AX1,Q9P253 2 +Nuclear pore outer ring 0.3802125919869282 0.3214126945649771 0.7478976642031689 1.0 0.9496788140165932 8 Q8NFH4,Q96EE3,Q8WUM0,Q8NFH3,Q9BW27,P57740,Q12769 7 +Basolateral plasma membrane 0.3102436503987664 0.2998285567416699 0.7643079317240673 1.0 0.9575562440065728 30 O15439,P41440,Q14168 3 +Basal cortex 0.5061174551386728 0.2979766783227282 0.765720963533445 1.0 0.9579658011865226 2 O75122 1 +Cell division site 0.335893048268753 0.293403768976307 0.7692135449331052 1.0 0.958088456176068 15 P11233,Q9UHB6 2 +Nuclear outer membrane 0.36053187702086 0.282060984341955 0.7778967490361408 1.0 0.9636305233846576 10 Q9UBM7 1 +Chromatin silencing complex 0.4163395345466618 0.2719955945370849 0.7856254067447237 1.0 0.9684410203422306 6 Q8IXJ6,Q13185 2 +Ciliary base 0.4161163348670391 0.2712846968243955 0.7861720754705637 1.0 0.9684410203422306 6 A0AVF1,P10644 2 +Neuron spine 0.3069059064270379 0.2636986490697054 0.7920121365868069 1.0 0.9729174156957712 28 Q9UQB8,Q14168 2 +Microbody 0.295327720437403 0.2357145214516341 0.8136542008810279 1.0 0.9796346901445612 35 P48735,Q9NR77,Q8N4Q0,O75874 4 +P body 0.3034527801976607 0.2313784385873485 0.8170208142438937 1.0 0.9796346901445612 25 Q9UIV1,P60900,Q7Z739,P62312,Q13501 5 +Cul4a ring e3 ubiquitin ligase complex 0.5010199918400638 0.1993249747570617 0.8420085440987319 1.0 0.9922469477710943 3 Q13619,Q92990 2 +Sperm midpiece 0.3920333578067929 0.1985402353024728 0.8426224080278342 1.0 0.9922469477710943 6 Q9BW83,Q13501 2 +Golgi apparatus 0.3116058392468986 0.1878087211654577 0.8510265989230312 1.0 0.99387317810399 219 O95197,Q9Y3B3,Q8TB61,Q99523,Q9H7Z7,O95721,Q8NCH0,P80303,P06280,P10321,Q6ZRP7,Q15691,P49755,Q9NX40,P50897,P61923,O60645,P16278,Q15392,Q9NR31,Q02818,Q5VW38,P05067,Q9BRK5,Q9Y282,Q8IV08,L0R6Q1,Q5W0Z9,Q9BZH6,P62820,O75503,P62993,Q14108,P18085,O14828,Q9UQB8,Q8N4V1,Q10472,Q8N6T3,Q9UM00,Q93050,P24390,Q9BW83,O43505,O15118,Q9UNZ2,Q9NPR9,Q92542,Q9H8Y8,Q9UQR1,O00461,P04062,P51809,P61106,O43290,P40616,O95456,Q92572,O43852 59 +Apical part of cell 0.2814040390812391 0.180792964686503 0.856530085480196 1.0 0.9973293489749516 46 P61421,P41440,P05067,P08183,O15439,Q99797 6 +Nuclear ubiquitin ligase complex 0.3250455448950329 0.1614098524492417 0.8717706072888292 1.0 1.0 11 Q96DE5,Q9NXR7 2 +Rna polymerase ii transcription regulator complex 0.3021879126002535 0.15210728432493 0.8791023190024827 1.0 1.0 18 P18074,Q13185,Q99729,P17096 4 +Clathrin coated vesicle 0.2807985337602345 0.1295357119686546 0.896933768916027 1.0 1.0 39 Q14108,Q8NC96,Q5VW38,Q99523,P61106,P51809,P49755,Q9NVZ3,P42892 9 +Prp19 complex 0.3203764320785595 0.1284271187590834 0.8978109711874862 1.0 1.0 10 Q8WYA6,P11142,Q9BZJ0,Q9NW64,O43660,O75934,Q9P013,Q9HCS7,Q9UMS4 9 +Mitochondrial crista 0.4261827079934746 0.1258127050892638 0.8998801844849162 1.0 1.0 2 O60313 1 +Endosome membrane 0.2604573636958779 0.1216343528149786 0.9031886058654268 1.0 1.0 92 Q86YV9,P10321,Q99523,Q15904,P42892,P61421,P61020,Q8IV08,Q14849,Q99816,Q14108,Q8N4V1,P04083,Q96J02,Q93050,P11279,O15118,O00461,P51809,Q9Y487 20 +Specific granule lumen 0.3096383791432708 0.1212867287106311 0.9034639313689754 1.0 1.0 12 Q92820,Q99519,Q9BS26 3 +Postsynaptic recycling endosome 0.4188417618270784 0.1147874994393484 0.908613557560914 1.0 1.0 2 Q86Y82 1 +Perinuclear endoplasmic reticulum 0.3662719477337698 0.1088430223008462 0.913326999640591 1.0 1.0 5 P51572,Q9BZF3,P17655,Q8N5K1 4 +Platelet alpha granule membrane 0.4139477977161517 0.1078759776964728 0.9140940729215834 1.0 1.0 2 Q06481 1 +Immunological synapse 0.3086987946345035 0.100938581678944 0.919599215746262 1.0 1.0 11 Q9Y639,P10644 2 +Pigment granule 0.260265113570076 0.0938129842890187 0.9252577172043916 1.0 1.0 57 P41440,P11279,P57088,Q92820,P61020,Q92542,P49755,P07237,P62820,P55209,Q93050,O43852,O14773 13 +Lamin filament 0.4283965728274153 0.0796273941586531 0.9365336070020084 1.0 1.0 3 P20700,P56537 2 +Retromer complex 0.3062142273099028 0.0709242229628063 0.9434580647815892 1.0 1.0 8 Q9UBQ0,O75436,O60749,Q9UMY4,Q9UNH7,O60493,Q96QK1 7 +Postsynaptic endosome 0.4190126478988113 0.068912778455793 0.9450590469647656 1.0 1.0 3 Q86Y82,P20339 2 +Aryl hydrocarbon receptor complex 0.3711256117455116 0.0614375272798199 0.951010766346382 1.0 1.0 2 O00170 1 +Spectrin associated cytoskeleton 0.4104447164422709 0.0600191521692055 0.952140380961892 1.0 1.0 3 Q12955,P11171 2 +Ap 3 adaptor complex 0.4041952139849163 0.0540501995483348 0.9568951692082412 1.0 1.0 3 Q92572 1 +Zonula adherens 0.3314285714285662 0.0394006940326494 0.9685709265826244 1.0 1.0 4 P35221,Q92692,P14923 3 +Transcription elongation factor complex 0.2868194426074599 0.038461062050445 0.9693200764805998 1.0 1.0 12 Q7KZ85,Q9GZS3,O00267 3 +Pericentric heterochromatin 0.2920468757600906 0.0367877151947291 0.9706542692737448 1.0 1.0 9 Q13185,P83916 2 +Presynaptic active zone 0.2823079521667296 0.0358669250754987 0.9713884688557148 1.0 1.0 14 P41440,Q9Y639,Q13363,P05067 4 +Zymogen granule 0.3799248598883318 0.0347492094384253 0.9722797211422444 1.0 1.0 3 P49755 1 +Hulc complex 0.3136215334420895 0.0310872688870848 0.9751999427199364 1.0 1.0 2 Q5VTR2 1 +Rough endoplasmic reticulum 0.2655169279361977 0.0054154636905659 0.9956791062517056 1.0 1.0 33 Q9UQB8,Q5BJF2 2 +Neurofilament 0.2949816401468769 0.003672625455672 0.9970696754387656 1.0 1.0 3 Q16352,P07197 2 +Sin3 complex 0.2853061224489745 0.0012299678793125 0.9990186278662532 1.0 1.0 4 Q13547,Q96ST3,Q9UBU8 3 diff --git a/msigdb_gocc/selections.json b/msigdb_gocc/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..ea206889e7ae11a695796bfe4580c5840582ac02 --- /dev/null +++ b/msigdb_gocc/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["90s preribosome", "9plus0 non motile cilium", "9plus2 motile cilium", "A band", "Acrosomal membrane", "Acrosomal vesicle", "Actin based cell projection", "Actin cytoskeleton", "Actin filament", "Actin filament bundle", "Actomyosin", "Adherens junction", "Aggresome", "Alpha dna polymerase primase complex", "Alveolar lamellar body", "Aminoacyl trna synthetase multienzyme complex", "Ampa glutamate receptor complex", "Amphisome", "Amphisome membrane", "Anaphase promoting complex", "Anchored component of membrane", "Anchored component of plasma membrane", "Anchored component of postsynaptic membrane", "Anchored component of synaptic membrane", "Anchored component of synaptic vesicle membrane", "Anchoring junction", "Annulate lamellae", "Ap 1 adaptor complex", "Ap 3 adaptor complex", "Ap type membrane coat adaptor complex", "Apical dendrite", "Apical junction complex", "Apical part of cell", "Apical plasma membrane", "Apicolateral plasma membrane", "Arp2 3 protein complex", "Aryl hydrocarbon receptor complex", "Aster", "Astrocyte end foot", "Astrocyte projection", "Atac complex", "Atpase complex", "Atpase dependent transmembrane transport complex", "Autolysosome", "Autophagosome", "Autophagosome membrane", "Axolemma", "Axon", "Axon cytoplasm", "Axon hillock", "Axon initial segment", "Axonal growth cone", "Azurophil granule", "Azurophil granule lumen", "Azurophil granule membrane", "B wich complex", "Barr body", "Basal cortex", "Basal dendrite", "Basal part of cell", "Basement membrane", "Basolateral plasma membrane", "Bcl 2 family protein complex", "Beta catenin destruction complex", "Beta catenin tcf complex", "Bleb", "Bloc complex", "Blood microparticle", "Box c d rnp complex", "Box h aca rnp complex", "Box h aca snornp complex", "Box h aca telomerase rnp complex", "Brca1 a complex", "Brca1 c complex", "Brisc complex", "Brush border", "Brush border membrane", "Cajal body", "Calcium and calmodulin dependent protein kinase complex", "Calcium channel complex", "Camp dependent protein kinase complex", "Carboxy terminal domain protein kinase complex", "Caspase complex", "Catalytic complex", "Catalytic step 1 spliceosome", "Catalytic step 2 spliceosome", "Catenin complex", "Cation channel complex", "Cation transporting atpase complex", "Caveola", "Ccaat binding factor complex", "Ccr4 not complex", "Ccr4 not core complex", "Cd40 receptor complex", "Cd95 death inducing signaling complex", "Cdc73 paf1 complex", "Cell body", "Cell body membrane", "Cell cell contact zone", "Cell cell junction", "Cell cortex", "Cell cortex region", "Cell division site", "Cell leading edge", "Cell pole", "Cell projection membrane", "Cell substrate junction", "Cell surface", "Cell tip", "Cell trailing edge", "Central element", "Centriolar satellite", "Centriolar subdistal appendage", "Centriole", "Centrosome", "Cerebellar mossy fiber", "Chaperone complex", "Chaperonin containing t complex", "Chitosome", "Chloride channel complex", "Cholinergic synapse", "Chromaffin granule", "Chromaffin granule membrane", "Chromatin", "Chromatin silencing complex", "Chromatoid body", "Chromocenter", "Chromosomal region", "Chromosome", "Chromosome centromeric core domain", "Chromosome centromeric region", "Chromosome passenger complex", "Chromosome telomeric region", "Chromosome telomeric repeat region", "Cia complex", "Ciliary basal body", "Ciliary base", "Ciliary membrane", "Ciliary plasm", "Ciliary rootlet", "Ciliary tip", "Ciliary transition zone", "Cilium", "Cis golgi network", "Cis golgi network membrane", "Clathrin adaptor complex", "Clathrin coat", "Clathrin coat of coated pit", "Clathrin coat of endocytic vesicle", "Clathrin coated endocytic vesicle", "Clathrin coated endocytic vesicle membrane", "Clathrin coated pit", "Clathrin coated vesicle", "Clathrin coated vesicle membrane", "Clathrin complex", "Clathrin sculpted gamma aminobutyric acid transport vesicle", "Clathrin sculpted vesicle", "Clathrin vesicle coat", "Cleavage furrow", "Cluster of actin based cell projections", "Coated vesicle", "Coated vesicle membrane", "Cohesin complex", "Collagen containing extracellular matrix", "Collagen trimer", "Commitment complex", "Compact myelin", "Condensed chromosome", "Condensed chromosome centromeric region", "Condensed nuclear chromosome", "Condensin complex", "Contractile fiber", "Contractile ring", "Cop9 signalosome", "Copi coated vesicle", "Copi coated vesicle membrane", "Copi vesicle coat", "Copii coated er to golgi transport vesicle", "Copii vesicle coat", "Core mediator complex", "Cornified envelope", "Cortical actin cytoskeleton", "Cortical cytoskeleton", "Cortical endoplasmic reticulum", "Cortical granule", "Costamere", "Crd mediated mrna stability complex", "Ctf18 rfc like complex", "Cul2 ring ubiquitin ligase complex", "Cul3 ring ubiquitin ligase complex", "Cul4 ring e3 ubiquitin ligase complex", "Cul4a ring e3 ubiquitin ligase complex", "Cul4b ring e3 ubiquitin ligase complex", "Cul5 ring ubiquitin ligase complex", "Cullin ring ubiquitin ligase complex", "Cuticular plate", "Cyclin a2 cdk2 complex", "Cyclin cdk positive transcription elongation factor complex", "Cyclin dependent protein kinase holoenzyme complex", "Cytochrome complex", "Cytolytic granule", "Cytoplasmic dynein complex", "Cytoplasmic exosome rnase complex", "Cytoplasmic microtubule", "Cytoplasmic region", "Cytoplasmic side of endoplasmic reticulum membrane", "Cytoplasmic side of endosome membrane", "Cytoplasmic side of lysosomal membrane", "Cytoplasmic side of membrane", "Cytoplasmic stress granule", "Cytoplasmic ubiquitin ligase complex", "Cytoskeleton of presynaptic active zone", "Cytosolic large ribosomal subunit", "Cytosolic region", "Cytosolic ribosome", "Cytosolic small ribosomal subunit", "Death inducing signaling complex", "Dendrite cytoplasm", "Dendrite membrane", "Dendrite terminus", "Dendritic growth cone", "Dendritic shaft", "Dendritic spine membrane", "Dendritic tree", "Dense body", "Dense core granule", "Dentate gyrus mossy fiber", "Derlin 1 retrotranslocation complex", "Desmosome", "Dihydrolipoyl dehydrogenase complex", "Distal axon", "Dna packaging complex", "Dna polymerase complex", "Dna repair complex", "Dna replication factor c complex", "Dna replication preinitiation complex", "Dopaminergic synapse", "Dynactin complex", "Dynein axonemal particle", "Dynein complex", "Dystrophin associated glycoprotein complex", "Early endosome", "Early endosome lumen", "Early endosome membrane", "Early phagosome", "Elongator holoenzyme complex", "Elongin complex", "Emc complex", "Endocytic vesicle", "Endocytic vesicle lumen", "Endocytic vesicle membrane", "Endolysosome", "Endolysosome lumen", "Endolysosome membrane", "Endopeptidase complex", "Endoplasmic reticulum", "Endoplasmic reticulum chaperone complex", "Endoplasmic reticulum exit site", "Endoplasmic reticulum golgi intermediate compartment", "Endoplasmic reticulum golgi intermediate compartment membrane", "Endoplasmic reticulum lumen", "Endoplasmic reticulum palmitoyltransferase complex", "Endoplasmic reticulum plasma membrane contact site", "Endoplasmic reticulum protein containing complex", "Endoplasmic reticulum quality control compartment", "Endoplasmic reticulum tubular network", "Endoplasmic reticulum tubular network membrane", "Endoribonuclease complex", "Endosome", "Endosome lumen", "Endosome membrane", "Envelope", "Enzyme activator complex", "Epsilon dna polymerase complex", "Equatorial microtubule organizing center", "Er membrane insertion complex", "Er to golgi transport vesicle membrane", "Er ubiquitin ligase complex", "Esc e z complex", "Escrt complex", "Escrt i complex", "Escrt iii complex", "Euchromatin", "Eukaryotic translation initiation factor 2 complex", "Eukaryotic translation initiation factor 2b complex", "Eukaryotic translation initiation factor 3 complex", "Eukaryotic translation initiation factor 3 complex eif3m", "Eukaryotic translation initiation factor 4f complex", "Excitatory synapse", "Exocyst", "Exocytic vesicle", "Exon exon junction complex", "Exoribonuclease complex", "External encapsulating structure", "External side of apical plasma membrane", "External side of plasma membrane", "Extrinsic component of cytoplasmic side of plasma membrane", "Extrinsic component of endoplasmic reticulum membrane", "Extrinsic component of endosome membrane", "Extrinsic component of external side of plasma membrane", "Extrinsic component of membrane", "Extrinsic component of mitochondrial inner membrane", "Extrinsic component of organelle membrane", "Extrinsic component of plasma membrane", "Extrinsic component of postsynaptic membrane", "Extrinsic component of postsynaptic specialization membrane", "Extrinsic component of synaptic membrane", "F actin capping protein complex", "Fascia adherens", "Female germ cell nucleus", "Female pronucleus", "Fibrillar center", "Ficolin 1 rich granule", "Ficolin 1 rich granule lumen", "Ficolin 1 rich granule membrane", "Filamentous actin", "Filopodium", "Filopodium membrane", "Filopodium tip", "Filtration diaphragm", "Flemming body", "Flotillin complex", "Gaba ergic synapse", "Gamma secretase complex", "Gamma tubulin complex", "Gamma tubulin large complex", "Gap junction", "Gator2 complex", "Gemini of coiled bodies", "Germ cell nucleus", "Glial cell projection", "Glutamatergic synapse", "Glycinergic synapse", "Glycogen granule", "Glycoprotein complex", "Golgi apparatus", "Golgi apparatus subcompartment", "Golgi associated vesicle", "Golgi associated vesicle membrane", "Golgi cis cisterna", "Golgi cisterna", "Golgi cisterna membrane", "Golgi lumen", "Golgi medial cisterna", "Golgi membrane", "Golgi stack", "Golgi transport complex", "Gpi anchor transamidase complex", "Granular component", "Growth cone membrane", "Gtpase complex", "Guanyl nucleotide exchange factor complex", "H4 h2a histone acetyltransferase complex", "H4 histone acetyltransferase complex", "Haus complex", "Hemidesmosome", "Hemoglobin complex", "Heterochromatin", "Hfe transferrin receptor complex", "High density lipoprotein particle", "Hippocampal mossy fiber", "Hippocampal mossy fiber to ca3 synapse", "Histone deacetylase complex", "Histone methyltransferase complex", "Histone pre mrna 3 end processing complex", "Hops complex", "Host cellular component", "Hrd1p ubiquitin ligase erad l complex", "Hulc complex", "I band", "Ikappab kinase complex", "Immunological synapse", "Inclusion body", "Inflammasome complex", "Inhibitory synapse", "Inner mitochondrial membrane protein complex", "Ino80 complex", "Ino80 type complex", "Insulin responsive compartment", "Integral component of cytoplasmic side of endoplasmic reticulum membrane", "Integral component of lysosomal membrane", "Integral component of presynaptic active zone membrane", "Integral component of synaptic vesicle membrane", "Integrator complex", "Integrin complex", "Intercalated disc", "Intercellular bridge", "Intercellular canaliculus", "Intermediate filament", "Intermediate filament cytoskeleton", "Intracellular protein containing complex", "Intraciliary transport particle", "Intraciliary transport particle a", "Intraciliary transport particle b", "Intrinsic component of endoplasmic reticulum membrane", "Intrinsic component of golgi membrane", "Intrinsic component of mitochondrial inner membrane", "Intrinsic component of mitochondrial membrane", "Intrinsic component of mitochondrial outer membrane", "Intrinsic component of nuclear inner membrane", "Intrinsic component of organelle membrane", "Intrinsic component of peroxisomal membrane", "Intrinsic component of plasma membrane", "Intrinsic component of postsynaptic density membrane", "Intrinsic component of postsynaptic membrane", "Intrinsic component of postsynaptic specialization membrane", "Intrinsic component of presynaptic active zone membrane", "Intrinsic component of presynaptic membrane", "Intrinsic component of synaptic membrane", "Intrinsic component of synaptic vesicle membrane", "Intrinsic component of vacuolar membrane", "Ion channel complex", "Iron sulfur cluster assembly complex", "Iswi type complex", "Juxtaparanode region of axon", "Keratin filament", "Kinesin complex", "Kinetochore microtubule", "Lamellar body", "Lamellipodium", "Lamellipodium membrane", "Lamin filament", "Large ribosomal subunit", "Late endosome", "Late endosome membrane", "Lateral element", "Lateral part of cell", "Lateral plasma membrane", "Leading edge membrane", "Lewy body", "Lipid droplet", "Lipopolysaccharide receptor complex", "Low density lipoprotein particle", "Lsm1 7 pat1 complex", "Lsm2 8 complex", "Lumenal side of endoplasmic reticulum membrane", "Lumenal side of membrane", "Lysosomal lumen", "M band", "Magnesium dependent protein serine threonine phosphatase complex", "Main axon", "Male germ cell nucleus", "Male pronucleus", "Manchette", "Mcm complex", "Mcrd mediated mrna stability complex", "Mediator complex", "Meiotic cohesin complex", "Meiotic spindle", "Membrane coat", "Membrane microdomain", "Membrane protein complex", "Messenger ribonucleoprotein complex", "Methylosome", "Methyltransferase complex", "Mhc class i peptide loading complex", "Mhc class i protein complex", "Mhc protein complex", "Mib complex", "Micos complex", "Microbody", "Microbody lumen", "Microbody membrane", "Microtubule", "Microtubule associated complex", "Microtubule bundle", "Microtubule cytoskeleton", "Microtubule end", "Microtubule minus end", "Microtubule organizing center", "Microtubule organizing center attachment site", "Microtubule plus end", "Microvillus", "Microvillus membrane", "Midbody", "Mismatch repair complex", "Mitochondria associated endoplasmic reticulum membrane", "Mitochondrial alpha ketoglutarate dehydrogenase complex", "Mitochondrial crista", "Mitochondrial envelope", "Mitochondrial intermembrane space protein transporter complex", "Mitochondrial large ribosomal subunit", "Mitochondrial matrix", "Mitochondrial permeability transition pore complex", "Mitochondrial protein containing complex", "Mitochondrial proton transporting atp synthase complex coupling factor f o", "Mitochondrial pyruvate dehydrogenase complex", "Mitochondrial small ribosomal subunit", "Mitochondrial tricarboxylic acid cycle enzyme complex", "Mitochondrion", "Mitotic cohesin complex", "Mitotic spindle", "Mitotic spindle astral microtubule", "Mitotic spindle microtubule", "Mitotic spindle midzone", "Mitotic spindle pole", "Mll1 2 complex", "Mll3 4 complex", "Mmxd complex", "Motile cilium", "Mpp7 dlg1 lin7 complex", "Mrna cleavage and polyadenylation specificity factor complex", "Mrna cleavage factor complex", "Mrna editing complex", "Multimeric ribonuclease p complex", "Multivesicular body", "Multivesicular body membrane", "Myelin sheath", "Myelin sheath abaxonal region", "Myelin sheath adaxonal region", "Myofilament", "Myosin complex", "Myosin filament", "Myosin ii complex", "N terminal protein acetyltransferase complex", "Nadh dehydrogenase complex", "Nascent polypeptide associated complex", "Nata complex", "Nbaf complex", "Neurofibrillary tangle", "Neurofilament", "Neuromuscular junction", "Neuron projection", "Neuron projection cytoplasm", "Neuron projection membrane", "Neuron projection terminus", "Neuron spine", "Neuron to neuron synapse", "Neuronal dense core vesicle", "Neuronal ribonucleoprotein granule", "Neurotransmitter receptor complex", "Nlrp3 inflammasome complex", "Nls dependent protein nuclear import complex", "Node of ranvier", "Non motile cilium", "Nonhomologous end joining complex", "Npbaf complex", "Nsl complex", "Nuclear body", "Nuclear chromosome", "Nuclear cyclin dependent protein kinase holoenzyme complex", "Nuclear envelope", "Nuclear envelope lumen", "Nuclear exosome rnase complex", "Nuclear inclusion body", "Nuclear inner membrane", "Nuclear lamina", "Nuclear membrane", "Nuclear outer membrane", "Nuclear outer membrane endoplasmic reticulum membrane network", "Nuclear periphery", "Nuclear pore", "Nuclear pore central transport channel", "Nuclear pore nuclear basket", "Nuclear pore outer ring", "Nuclear protein containing complex", "Nuclear replication fork", "Nuclear rna export factor complex", "Nuclear speck", "Nuclear stress granule", "Nuclear ubiquitin ligase complex", "Nucleocytoplasmic transport complex", "Nucleoid", "Nucleolar ribonuclease p complex", "Nucleolus", "Nucleotide activated protein kinase complex", "Nucleotide excision repair complex", "Nurd complex", "Nurf complex", "Oligosaccharyltransferase complex", "Organellar ribosome", "Organelle envelope lumen", "Organelle inner membrane", "Organelle membrane contact site", "Organelle subcompartment", "Origin recognition complex", "Outer dense fiber", "Outer kinetochore", "Outer membrane", "Outer mitochondrial membrane protein complex", "Oxidoreductase complex", "Oxoglutarate dehydrogenase complex", "P body", "Palmitoyltransferase complex", "Pam complex tim23 associated import motor", "Parallel fiber to purkinje cell synapse", "Paranodal junction", "Paranode region of axon", "Paraspeckles", "Pcg protein complex", "Peptidase complex", "Peptidase inhibitor complex", "Pericentric heterochromatin", "Pericentriolar material", "Periciliary membrane compartment", "Perikaryon", "Perinuclear endoplasmic reticulum", "Perinuclear region of cytoplasm", "Perinucleolar compartment", "Phagocytic cup", "Phagocytic vesicle", "Phagocytic vesicle membrane", "Phagolysosome", "Phagophore assembly site", "Phagophore assembly site membrane", "Phosphatase complex", "Photoreceptor connecting cilium", "Photoreceptor inner segment", "Photoreceptor outer segment", "Photoreceptor ribbon synapse", "Pi body", "Picln sm protein complex", "Pigment granule", "Pinosome", "Pip body", "Plasma membrane protein complex", "Plasma membrane raft", "Plasma membrane region", "Plasma membrane signaling receptor complex", "Platelet alpha granule", "Platelet alpha granule lumen", "Platelet alpha granule membrane", "Platelet dense granule", "Platelet dense granule lumen", "Platelet dense granule membrane", "Platelet dense tubular network", "Platelet dense tubular network membrane", "Pml body", "Podosome", "Polar microtubule", "Pole plasm", "Polymeric cytoskeletal fiber", "Polysomal ribosome", "Polysome", "Pore complex", "Post mrna release spliceosomal complex", "Postsynapse", "Postsynaptic cytoskeleton", "Postsynaptic cytosol", "Postsynaptic density intracellular component", "Postsynaptic density membrane", "Postsynaptic endosome", "Postsynaptic membrane", "Postsynaptic recycling endosome", "Postsynaptic specialization intracellular component", "Postsynaptic specialization membrane", "Prc1 complex", "Pre snornp complex", "Precatalytic spliceosome", "Prefoldin complex", "Preribosome", "Preribosome large subunit precursor", "Preribosome small subunit precursor", "Prespliceosome", "Presynapse", "Presynaptic active zone", "Presynaptic active zone cytoplasmic component", "Presynaptic active zone membrane", "Presynaptic cytoskeleton", "Presynaptic cytosol", "Presynaptic endocytic zone", "Presynaptic membrane", "Pronucleus", "Protease inhibitor complex", "Proteasome accessory complex", "Proteasome complex", "Proteasome core complex", "Proteasome core complex alpha subunit complex", "Proteasome core complex beta subunit complex", "Proteasome regulatory particle", "Proteasome regulatory particle base subcomplex", "Proteasome regulatory particle lid subcomplex", "Protein acetyltransferase complex", "Protein complex involved in cell adhesion", "Protein dna complex", "Protein kinase complex", "Protein lipid complex", "Protein phosphatase type 1 complex", "Protein phosphatase type 2a complex", "Proton transporting atp synthase complex", "Proton transporting atp synthase complex catalytic core f 1", "Proton transporting atp synthase complex coupling factor f o", "Proton transporting two sector atpase complex", "Proton transporting two sector atpase complex catalytic domain", "Proton transporting two sector atpase complex proton transporting domain", "Proton transporting v type atpase complex", "Proton transporting v type atpase v0 domain", "Proton transporting v type atpase v1 domain", "Proximal dendrite", "Prp19 complex", "Pseudopodium", "Ptw pp1 phosphatase complex", "Pwp2p containing subcomplex of 90s preribosome", "R2tp complex", "Ragulator complex", "Rdna heterochromatin", "Receptor complex", "Recycling endosome", "Recycling endosome membrane", "Replication fork", "Replisome", "Respirasome", "Respiratory chain complex iii", "Respiratory chain complex iv", "Retromer complex", "Ribbon synapse", "Ribonuclease mrp complex", "Ribonuclease p complex", "Ribonucleoprotein complex", "Ribonucleoprotein granule", "Ribose phosphate diphosphokinase complex", "Ribosomal subunit", "Ribosome", "Ripoptosome", "Risc loading complex", "Rna cap binding complex", "Rna polymerase complex", "Rna polymerase i complex", "Rna polymerase ii core complex", "Rna polymerase ii holoenzyme", "Rna polymerase ii transcription regulator complex", "Rna polymerase ii transcription repressor complex", "Rna polymerase iii complex", "Rna polymerase iii transcription regulator complex", "Rnai effector complex", "Rough endoplasmic reticulum", "Rough endoplasmic reticulum membrane", "Rpap3 r2tp prefoldin like complex", "Ruffle", "Ruffle membrane", "Saga complex", "Saga type complex", "Sarcolemma", "Sarcoplasm", "Sarcoplasmic reticulum lumen", "Sarcoplasmic reticulum membrane", "Scar complex", "Scf ubiquitin ligase complex", "Schaffer collateral ca1 synapse", "Schmidt lanterman incisure", "Sec61 translocon complex", "Secondary lysosome", "Secretory granule", "Secretory granule membrane", "Secretory vesicle", "Seh1 associated complex", "Septin cytoskeleton", "Serine protease inhibitor complex", "Serine type endopeptidase complex", "Serine type peptidase complex", "Set1c compass complex", "Sex chromatin", "Sex chromosome", "Side of membrane", "Signal peptidase complex", "Signal recognition particle", "Sin3 complex", "Sin3 type complex", "Site of dna damage", "Site of double strand break", "Site of polarized growth", "Sm like protein family complex", "Small ribosomal subunit", "Small subunit processome", "Smc5 smc6 complex", "Smn complex", "Smn sm protein complex", "Smooth endoplasmic reticulum", "Smooth endoplasmic reticulum membrane", "Snare complex", "Sno s rna containing ribonucleoprotein complex", "Sodium potassium exchanging atpase complex", "Somatodendritic compartment", "Sorting endosome", "Spanning component of membrane", "Specific granule", "Specific granule lumen", "Specific granule membrane", "Spectrin", "Spectrin associated cytoskeleton", "Sperm annulus", "Sperm connecting piece", "Sperm fibrous sheath", "Sperm head", "Sperm head plasma membrane", "Sperm midpiece", "Sperm plasma membrane", "Sperm principal piece", "Spermatoproteasome complex", "Spindle", "Spindle microtubule", "Spindle midzone", "Spindle pole", "Spindle pole centrosome", "Spliceosomal complex", "Spliceosomal snrnp complex", "Spliceosomal tri snrnp complex", "Stereocilium bundle", "Stereocilium membrane", "Stereocilium tip", "Striated muscle thin filament", "Sumo ligase complex", "Supramolecular complex", "Supramolecular polymer", "Swi snf complex", "Swr1 complex", "Synapse", "Synaptic membrane", "Synaptic vesicle membrane", "Synaptonemal structure", "T tubule", "Telomerase holoenzyme complex", "Terminal bouton", "Tertiary granule", "Tertiary granule lumen", "Tertiary granule membrane", "Tetraspanin enriched microdomain", "Tho complex", "Tight junction", "Tim22 mitochondrial import inner membrane insertion complex", "Tim23 mitochondrial import inner membrane translocase complex", "Tor complex", "Torc1 complex", "Trans golgi network", "Trans golgi network membrane", "Trans golgi network transport vesicle", "Trans golgi network transport vesicle membrane", "Transcription elongation factor complex", "Transcription export complex", "Transcription export complex 2", "Transcription factor tfiid complex", "Transcription factor tfiih holo complex", "Transcription factor tfiiic complex", "Transcription preinitiation complex", "Transcription regulator complex", "Transcription repressor complex", "Transferase complex", "Transferase complex transferring phosphorus containing groups", "Translation preinitiation complex", "Translocon complex", "Transport vesicle", "Transport vesicle membrane", "Transporter complex", "Trapp complex", "Tricarboxylic acid cycle enzyme complex", "Triglyceride rich plasma lipoprotein particle", "Trna methyltransferase complex", "Trna splicing ligase complex", "Tubular endosome", "U1 snrnp", "U12 type spliceosomal complex", "U2 snrnp", "U2 type catalytic step 2 spliceosome", "U2 type spliceosomal complex", "U2af complex", "U4 snrnp", "U5 snrnp", "U6 snrnp", "U7 snrnp", "Ubiquitin conjugating enzyme complex", "Ubiquitin ligase complex", "Unconventional myosin complex", "Uniplex complex", "Vacuolar lumen", "Vacuolar membrane", "Vacuolar proton transporting v type atpase v0 domain", "Vacuole", "Varicosity", "Vcp npl4 ufd1 aaa atpase complex", "Vesicle coat", "Vesicle lumen", "Vesicle membrane", "Vesicle tethering complex", "Wash complex", "Weibel palade body", "Wnt signalosome", "X chromosome", "Xy body", "Zona pellucida receptor complex", "Zonula adherens", "Zymogen granule", "Zymogen granule membrane"], "available_proteins": ["AAAS", "AARS", "AARS2", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR6", "ADAM17", "ADAR", "ADD1", "ADD3", "ADH5", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8L", "AKR1A1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOL2", "APOO", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARMCX3", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASPH", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "B4GAT1", "BABAM1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCLAF1", "BIRC6", "BLM", "BMS1", "BOLA2*", "BOP1", "BPTF", "BRCA1", "BRD2", "BRI3BP", "BRIX1", "BRMS1L", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BYSL", "C12orf43", "C12orf73", "C19orf70", "C1QBP", "C1orf35", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CAST", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC47", "CCDC86", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD3EAP", "CDC23", "CDC27", "CDC34", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKAL1", "CEBPZ", "CECR2", "CELF1", "CENPB", "CENPI", "CEP170", "CERS2", "CFAP20", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD4", "CHERP", "CHID1", "CHMP3", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLTC", "CMPK1", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT10", "CNOT3", "CNOT6", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG7", "COIL", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "CORO1B", "CORO1C", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CWC15", "CWF19L1", "CXorf57", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF13", "DCAF7", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DERL1", "DFFA", "DGCR8", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNTTIP2", "DOCK7", "DPF2", "DPM1", "DPP9", "DPYSL2", "DRG1", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI2", "ECSIT", "EDC3", "EDC4", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5A", "EIF6", "ELAC2", "ELAVL1", "ELOA", "ELOB", "ELP1", "ELP2", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "ENY2", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERH", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAHD1", "FAM162A", "FAM208A", "FAM49B", "FAM8A1", "FAM98A", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP4", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNTB", "FOXC1", "FOXK1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUCA2", "FUNDC2", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GGCX", "GGH", "GIGYF2", "GINS1", "GINS4", "GLA", "GLB1", "GLDC", "GLE1", "GLG1", "GLMN", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GNA13", "GNAI2", "GNAI3", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNS", "GOLGA3", "GOLGB1", "GOLIM4", "GORASP2", "GOT2", "GPAA1", "GPATCH4", "GPD2", "GPI", "GPR107", "GPR108", "GPS1", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSR", "GSTK1", "GSTM3", "GSTZ1", "GTF2E1", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAUS5", "HAX1", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HELLS", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIF1AN", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HOXA10", "HP1BP3", "HPF1", "HPS6", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILK", "ILVBL", "IMMT", "IMP3", "IMPDH2", "INA", "INCENP", "INF2", "INTS11", "INTS14", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "ISOC1", "IST1", "ITCH", "ITGB1", "IVD", "JUP", "KARS", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KIAA0368", "KIAA0391", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC2", "KLC4", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMP1", "LAMTOR1", "LAMTOR2", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDAH", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3BP", "LGMN", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC59", "LRWD1", "LSM2", "LSM6", "LSS", "LTA4H", "LTV1", "LUC7L", "LUC7L3", "LYAR", "LYPLA1", "MACF1", "MAGED2", "MAGT1", "MAK16", "MAP1B", "MAP1S", "MAP2K1", "MAP4", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARK2", "MARS", "MAT2A", "MATR3", "MAU2", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED16", "METTL13", "MFN1", "MFN2", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMGT1", "MMS19", "MOB4", "MOGS", "MORF4L1", "MOV10", "MPHOSPH10", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MTA1", "MTA2", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTPN", "MTX1", "MTX2", "MTX3", "MYBBP1A", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAGLU", "NAMPT", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFAF7", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFCD", "NENF", "NES", "NEU1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NISCH", "NKRF", "NLE1", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPLOC4", "NPM1", "NPTN", "NRBP1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "OAT", "OCIAD1", "OCLN", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL11", "OSBPL6", "OSBPL9", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAK2", "PAK4", "PALLD", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCM1", "PCNA", "PCNP", "PCYOX1", "PDCD11", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PECR", "PEF1", "PELP1", "PES1", "PEX14", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGK1", "PGM1", "PGM2", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHF6", "PHIP", "PI4KB", "PICALM", "PIGS", "PIGT", "PIN4", "PISD", "PITPNB", "PITRM1", "PKM", "PKN2", "PLAA", "PLBD2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA2", "PPAN", "PPIB", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPP1CA", "PPP1R10", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PPT1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2C", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTK7", "PTPA", "PTPN1", "PTRH2", "PUM3", "PURA", "PUS1", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RABGGTA", "RABL6", "RAC1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAD51AP1", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RARS2", "RBBP6", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM27", "RBM28", "RBM34", "RBM39", "RBM4", "RBM45", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "RECQL5", "REEP5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIF1", "RINT1", "RIOK2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF20", "RNF40", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA3", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF8", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCP2", "SCRIB", "SCRN1", "SDF4", "SDHA", "SDHB", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFXN1", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SIRT2", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35A4", "SLC35B2", "SLC3A2", "SLC6A15", "SLC9A3R1", "SLFN11", "SLIRP", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX2", "SNX3", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPCS2", "SPCS3", "SPEN", "SPTAN1", "SPTBN1", "SPTLC1", "SQLE", "SQSTM1", "SRCAP", "SRI", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "SSU72", "STAG2", "STARD3", "STAT3", "STAU1", "STAU2", "STEAP3", "STIP1", "STMN1", "STOML2", "STRAP", "STRBP", "STRN4", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TACO1", "TAF15", "TAMM41", "TAP1", "TAP2", "TARDBP", "TARS2", "TBCA", "TBCE", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TEX10", "TFAM", "TFG", "TFRC", "THG1L", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMMDC1", "TJP1", "TJP2", "TKT", "TLN1", "TMCO1", "TMED10", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM126B", "TMEM192", "TMEM201", "TMEM214", "TMEM230", "TMEM33", 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sha256:55bd4ce0da96927f496cdb9e5d961c0c033edba9376de072c758de607bd8401d +size 136258 diff --git a/msigdb_gomf/basic/plot_9.png b/msigdb_gomf/basic/plot_9.png new file mode 100644 index 0000000000000000000000000000000000000000..e61b1fd19045921ec0ed594147b0cbbb6753e167 --- /dev/null +++ b/msigdb_gomf/basic/plot_9.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:7aeed955d4a57d81f1ffe22ffc224ed1457ca79843c0ea951db2db79d579b4e8 +size 137884 diff --git a/msigdb_gomf/consensus.joblib b/msigdb_gomf/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..d2ec4ee5f9a87b7c5e8cb0c0b1a35d25b9af420f --- /dev/null +++ b/msigdb_gomf/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:57de6589ee07ac24047bca550fd16ca69c790f04b783f4158ff3cd745fe68012 +size 183956 diff --git a/msigdb_gomf/df_merge.tsv b/msigdb_gomf/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..9565e43d3393bf12adf081a7bbd108ba69de32d8 --- /dev/null +++ b/msigdb_gomf/df_merge.tsv @@ -0,0 +1,53 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Transporter activity 40 132 4.039996123847591 5.345208483187314e-05 62.22330097087379 172.27912621359224 2.173366592838491 0.2707201784543502 25.984753572620328 19.29276868436311 2.593156143256053 0.3916539604106395 1.0 0.0001458723093882 2.104321745202813e-06 8.309287879703148e-09 2.87728760604891e-09 +Ion transmembrane transporter activity 33 77 3.317474285895882 0.0009083527648872 37.34466019417476 101.497572815534 2.0154097423383375 0.2561362875319209 17.172953606300336 11.579295798802024 2.277787478419462 0.3756175790939143 1.0 0.186256583845972 0.010420981582986 5.988838088600445e-05 2.0460685018040805e-06 +Hydrolase activity acting on glycosyl bonds 10 24 3.146750533462721 0.0016509575495002 10.133495145631068 28.40776699029126 0.6089784953463463 0.2409908190925149 3.36301188653944 3.2424277527979313 1.935823411407979 0.3010513017078077 1.0 0.297366720714231 0.0054554424478239 1.2254814710404596e-06 0.0001674298904421 +Peptidase activity 23 98 3.0727811939390164 0.0021207392407731 29.021844660194176 113.626213592233 1.2572335980018865 0.3731282983707893 8.334453494010912 9.805689463637474 1.5136028692995414 0.3922229485757941 1.0 0.0026017792618755 2.425289924198528e-05 0.000706875479708 0.0001620732349227 +Hydrolase activity hydrolyzing o glycosyl compounds 9 18 2.909955545555812 0.0036148016748498 8.830097087378642 20.84223300970874 0.5983257656540719 0.2104301479001341 3.2223833352824554 2.4557961681485057 1.9540573665272416 0.2728112677124137 1.0 0.2068720246529641 0.0111977735740575 1.627158857801424e-07 1.264215009532698e-05 +Inorganic molecular entity transmembrane transporter activity 26 59 2.881993253065733 0.003951681949154 28.058252427184467 75.9635922330097 1.5031303400189615 0.2894264293069549 11.721339963426631 9.38477049228959 2.153051736566399 0.3821536813265525 1.0 0.3265601827841695 0.0307457901430655 0.0002628203994875 4.060158703582795e-05 +Endopeptidase activity 16 55 2.8292069532745123 0.0046663513099953 19.08495145631068 62.800970873786405 1.5604938505680932 0.2935756148549138 5.629332570724372 6.156865220927466 1.27979578418692 0.359984229645684 1.0 0.1896040470106967 0.0054813378254122 0.0022666889994947 0.0010209383960808 +Anion transmembrane transporter activity 17 30 2.8259231003473486 0.0047144580592728 18.594660194174757 45.61893203883495 1.6222323024349488 0.2373683627198559 9.346785472607134 6.017202751823004 1.8117646078257517 0.3183345645365742 1.0 0.1225807784723296 0.0340768670265117 0.0111927939680839 0.000105466830385 +Tetrapyrrole binding 6 14 2.802107692933323 0.0050769922667321 7.402912621359223 16.83252427184466 2.0044897428967667 0.1259264696495541 2.9589081005845346 2.0417036568087963 1.3464702305086589 0.2177422235164347 0.0105648562333688 0.0021781449325651 0.0001691618749341 0.0002941476334404 0.0009777151340482 +Exopeptidase activity 7 29 2.78675461383692 0.005323877629114 9.74514563106796 31.84223300970874 1.193034763402526 0.2308543476384821 3.0338864063053523 1.9513159274241312 1.6646797512653713 0.2911825093455628 1.0 0.0002008886603826 1.1440103838425673e-07 9.996092046331004e-05 0.0001328154988147 +Lipid binding 17 100 2.7711196420640816 0.005586389630751 30.883495145631063 138.65533980582524 0.9844637598707308 0.4289871747751645 8.92748670410201 14.760635317682617 1.446857667744565 0.4068298387995807 1.0 0.0052997906703188 0.070000542170405 0.0767687656812329 0.3232152414586814 +Serine hydrolase activity 4 17 2.6917215140584902 0.0071084274640031 6.934466019417476 18.83009708737864 1.2767207242593377 0.1489147276149277 2.386872767465543 1.965791668457755 1.709796217367629 0.2208345231085202 1.0 7.841716015172386e-05 9.59009812667239e-05 0.0057706709278987 0.0018554206644335 +Amide binding 14 90 2.67553651243055 0.0074609745758442 22.521844660194176 102.53398058252426 0.8716704131409604 0.4134472412494542 7.596116055031058 7.786365397071367 1.2519470693533183 0.3815633057547212 1.0 0.002970936132822 0.0001693703441638 0.0001367141746284 5.072641078026057e-05 +Nucleobase containing compound transmembrane transporter activity 10 14 2.674155808479455 0.0074917635579692 6.529126213592233 14.04126213592233 1.4296604886183193 0.212054291115069 3.2696940585469636 1.915888183904924 1.3255809572534116 0.2748813593420038 1.0 0.1430638950507344 0.0383266740374144 0.0069928111010265 1.453506221138282e-07 +Steroid binding 7 18 2.630977047728499 0.0085139785766805 8.424757281553399 21.398058252427184 1.4469817519716153 0.1523451695819165 3.035656818503787 2.066091501771892 1.85140774519605 0.2395996334984524 1.0 0.0016453439849387 0.0012677167474155 0.0010882828125207 0.0021262481017553 +Cholesterol binding 4 10 2.628939683392906 0.0085651551270997 5.25 13.29126213592233 1.1679703080780182 0.1357521674166823 1.9454015982929531 1.7674569958716484 1.7544522374432017 0.2116991383290636 1.0 0.0003865639533612 0.0001888015632795 0.0006827439557333 0.0026462677024259 +Organic acid transmembrane transporter activity 7 16 2.6005544861501138 0.0093073237643483 8.592233009708737 21.276699029126213 1.5973629153049684 0.1905568538747131 4.4420473133518055 2.549726956007885 1.3213968531498468 0.2647933566957936 1.0 1.0 0.4860789703868964 0.0058282629537454 0.0157807212414745 +Sterol binding 4 13 2.5468732998146306 0.010869288872203 5.495145631067961 16.27912621359223 1.1610523788441311 0.1592175050218891 2.159304933149918 1.9111962434971217 1.7231989277496158 0.231586711794193 1.0 0.0006661905409434 0.0003881131251702 0.0016056440309417 0.0068057981890614 +Oxidoreductase activity 39 190 2.521805818393524 0.01167541389567 52.54126213592233 227.42961165048544 0.490492706528076 0.5955656171597654 20.033606385640603 16.688970744458114 1.2909283370539455 0.4039853598071011 0.0911948275777874 7.109535134557627e-05 2.253610948288298e-08 3.036740787455048e-12 3.4626126869349854e-11 +Threonine type peptidase activity 5 9 2.5204619110817696 0.0117200921821576 3.8106796116504857 8.762135922330097 1.392634148189787 0.2146040118876429 1.6274593113109357 0.6695334565847216 1.0340073360925757 0.2572219198248905 1.0 0.0652597674910206 0.0078714328443906 0.0002735626391213 2.5790420180080805e-05 +Peptide binding 8 61 2.5133679888858733 0.0119584524044593 17.133495145631066 70.30339805825243 1.21997288878307 0.3503559587509399 5.621054768990946 6.443005397350486 1.219878183292811 0.3773673755377006 1.0 0.0333931709842731 0.0030251437486506 0.0092019955481875 0.0018348624553955 +Alcohol binding 4 13 2.505040037123373 0.0122437532952397 5.70873786407767 16.094660194174757 1.0972550148478282 0.1642412137618775 2.3364194162363723 2.1334758164294443 1.72577974721897 0.2306417307890987 1.0 0.0017444833819259 0.0013677912764581 0.0068683859678987 0.0316686896009918 +Threonine type endopeptidase activity 5 8 2.4991354583278875 0.0124496713168613 3.7135922330097086 7.970873786407767 1.4913184573846054 0.1902243906475925 1.515457478026574 0.1681602725795027 1.0170822776023185 0.2455850375425174 1.0 0.0470522829573702 0.0039921150854813 6.194004931981708e-05 2.1281179634986496e-06 +Serine type exopeptidase activity 3 7 2.472213765688372 0.0134279196376194 3.783980582524272 6.997572815533981 1.020609253431403 0.1137432544246352 1.3363606860118669 0.0492066381861973 1.87035730934538 0.1990592265121372 1.0 8.586603742440297e-06 1.0152328729907457e-06 3.788095303003865e-05 0.0005472376514181 +Carboxypeptidase activity 3 12 2.466156655914497 0.0136571589904437 3.941747572815534 11.944174757281552 0.6619369631013473 0.2217581052142344 1.5253536449314826 0.7722681563953175 1.6063564059694095 0.2594343390807456 1.0 0.0001966568602221 7.654983120717976e-05 0.0024022577840735 0.0260591762772921 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 5 24 2.4524879366209515 0.0141872136357594 9.395631067961164 29.8373786407767 1.5709767518568172 0.2393367467664754 3.119976403291062 3.762391942431812 1.2135099906711824 0.3124947384976632 0.0181601378063976 0.0734458650364987 0.0126378967280994 0.0247674911995091 0.0781023944722422 +Nucleotide transmembrane transporter activity 8 12 2.451648175395153 0.0142203624688599 5.606796116504855 12.029126213592232 1.4217258291760082 0.2036087501116975 3.0234925518113496 1.8899648667798992 1.291115513359647 0.2666064512499804 1.0 0.0963063052639835 0.0173819675279631 0.0014320459890063 2.2271125946053025e-07 +Organophosphate ester transmembrane transporter activity 8 12 2.451648175395153 0.0142203624688599 5.665048543689321 12.143203883495143 1.4298365636921646 0.2056324024803549 3.029697948284232 1.927415248708952 1.2819429632405106 0.2680490563295835 1.0 0.1006582454154426 0.0190005699483642 0.0017174581383874 3.60952156437701e-07 +Phosphatidylcholine binding 3 8 2.451115375526049 0.0142414296888107 2.2524271844660193 7.929611650485437 1.2697801287388335 0.1567893034984199 1.081337239384838 1.04388968498945 1.4953842980517238 0.2256102823610289 1.0 0.0026008925831016 0.000453663444764 0.0061570039439817 0.0060423314672148 +Organic anion transmembrane transporter activity 11 22 2.4371610530442767 0.0148030846935056 12.951456310679612 30.182038834951456 1.56101282472555 0.2452312368187786 6.880574373146614 3.5222410835885483 1.575669523214114 0.314839840161206 1.0 1.0 0.565173788309953 0.1492356701793886 0.0024004575856903 +Nadp binding 4 16 2.388907503637795 0.0168985562271943 3.966019417475728 17.985436893203882 0.66085030998649 0.497161667914878 2.1141710210905544 1.9470619024167608 0.8006079385844883 0.3067322240884021 1.0 0.0121686135974036 0.0003475618019176 0.0014099836558107 0.0059055963574577 +Molecular transducer activity 9 23 2.387153027750508 0.0169794219816343 10.91747572815534 33.40533980582524 1.343848990749489 0.2329582295822712 4.7124072380860955 5.830391636254363 1.6098335072319665 0.2956883791113679 1.0 0.7160221244847005 0.4597588064413886 0.7507835861640124 0.8007041281508098 +Serine type carboxypeptidase activity 3 5 2.377196291714637 0.0174448020821023 3.0558252427184467 4.997572815533981 1.0019911760482532 0.1105835516254352 1.1231414198895626 0.0492066381861973 1.8086551291944464 0.1930654928989846 1.0 1.0361647864625089e-06 4.151068855161726e-08 1.6228361660218084e-06 2.53552831216742e-05 +Protein transporter activity 4 14 2.356345990066395 0.0184557188359806 6.053398058252427 14.696601941747574 1.6882240898296943 0.1359359142649309 2.957968193176 1.443999336657768 1.4805047019217734 0.2345897542974644 1.0 0.0002227197090729 0.0017488676437986 0.0028063338575205 0.0009678132279787 +Calcium ion binding 14 62 2.352311960176656 0.0186571203291225 21.00485436893204 81.67961165048544 0.6464856503310022 0.4940276647939897 7.408010340962093 8.52860815905726 1.2261945166831902 0.3858741960292539 1.0 0.3860509975104039 0.7551722514244638 0.0723082521777716 0.2584714363587629 +Protein transmembrane transporter activity 2 11 2.3377973458948884 0.0193977633686011 4.37621359223301 11.264563106796116 1.6409152716253632 0.1284874270119089 2.3258190399954897 0.995332092405782 1.387057072324357 0.2266762256512647 1.0 6.765318543664244e-05 0.0005470061355849 0.0006143549700213 0.0009601967587914 +Macromolecule transmembrane transporter activity 2 12 2.3338892592275724 0.0196015213055928 4.820388349514563 12.281553398058252 1.6605285757306012 0.1306403746261988 2.4754663863133306 1.0160601209961664 1.3599823000893485 0.2280235038874096 1.0 0.0001122733832082 0.0008978593047678 0.0011814468070448 0.0002599861644489 +Cation transmembrane transporter activity 22 56 2.280519968505786 0.0225768678511195 25.62135922330097 70.51699029126213 1.766742880952279 0.2698419237572138 12.29126021871486 8.422243011776631 2.00238274385689 0.3706372466673562 1.0 0.6755398045514229 0.186637380486808 0.0039501779963618 0.0007312053705791 +Lipid transporter activity 6 14 2.248109030946414 0.0245692383600355 6.546116504854369 19.805825242718445 0.7389006587243017 0.301332987440896 3.074370954053146 3.741159812966952 1.4134673193588587 0.2984913911167897 1.0 0.310874529382391 0.1717287687817776 0.0380983070787084 0.076084322036482 +Monooxygenase activity 2 5 2.209862474108653 0.0271147082985261 4.043689320388349 8.322815533980583 1.6049222537693364 0.1501440468766332 1.612461779657682 1.2307404965531048 1.237349324058907 0.2369071661653372 0.0052894412236981 0.0073558029266518 0.0021930786590517 0.0264830942684438 0.0384644870542898 +Exogenous protein binding 3 14 2.1937290984179967 0.0282548906261759 4.509708737864078 15.157766990291265 0.7214109752050332 0.2527966464979699 2.499010078306418 1.9009100692398744 1.5211756979359785 0.2791170769282048 1.0 0.1952735388158895 0.0705821305211966 0.0940672040532474 0.1688710877285008 +Growth factor receptor binding 8 16 2.1893235507143176 0.0285733318044942 5.233009708737864 16.303398058252426 0.6012049824390195 0.4932334837741021 2.455245557470486 2.477606131434232 0.8745174126419827 0.327387299755004 1.0 1.0 0.416129272954638 0.1467586347483675 0.0473842035132311 +Quaternary ammonium group binding 2 11 2.182184536090068 0.0290959161188466 2.8567961165048543 12.12864077669903 0.9707568143407772 0.2573327609820879 1.4849985868988949 1.260087490061347 1.304146106648176 0.2795917987269193 1.0 0.0049155620827658 0.0011959433226113 0.0152248647419399 0.0193421266882966 +Electron transfer activity 9 41 2.1798086275767647 0.0292716501492624 14.919902912621358 52.12621359223301 0.5312195787834075 0.4459804256520286 6.65997259318913 4.498499451328372 1.405540355221493 0.3721784721862224 1.0 0.0832266786690803 0.0161267578272062 0.0001434833065057 0.0083741768444535 +Inorganic anion transmembrane transporter activity 7 11 2.1681776641434967 0.0301451715540661 7.427184466019417 19.274271844660195 1.0921593405593897 0.2441056926448881 3.717191605498929 3.7816647851785734 1.4014196343960104 0.2816216967014333 1.0 0.0257535715284909 0.0139156518076104 0.0081044088621321 0.0007365436562396 +Phosphatidylserine binding 1 9 2.137985056548042 0.0325179560880597 2.029126213592233 10.060679611650484 0.6615116985008255 0.3340719518205703 1.5854698894895154 0.9597266622759548 1.1646704221215245 0.2873190862432436 1.0 0.1263420182810564 0.0299460957191466 0.1457934990596532 0.3923613968521051 +Isocitrate dehydrogenase activity 1 5 2.10981464482015 0.0348743245356633 1.8349514563106797 4.495145631067961 -0.0268416016144192 0.3268992301433215 1.18113888908689 0.4999764345469411 1.4254920509394828 0.309635855483207 1.0 0.0002241871259369 0.0009157120850054 0.0055254488719224 0.0209220238917207 +Phospholipid binding 9 61 2.094582396613866 0.0362081314099356 18.890776699029125 88.4635922330097 0.777309720287493 0.452120200534915 6.970479526806733 10.51702894240924 1.1988133109990275 0.3785217149858343 1.0 0.0564535296707662 0.1699463357209449 0.5970108358969223 0.6992155418503764 +Modified amino acid binding 4 19 2.0594712061548144 0.0394491206020624 4.446601941747573 21.354368932038835 0.8157790161756342 0.4133026066112408 2.099367243274066 1.7995833767593454 0.9656025978141096 0.3166170247143811 1.0 0.2068720246529641 0.0111977735740575 0.0057706709278987 0.0264834749534085 +Metalloendopeptidase activity 5 15 2.0591327097971788 0.0394815271246753 5.449029126213592 14.364077669902912 1.4597326207035937 0.2246869419023046 2.4848715129851016 0.6671711573432166 0.9390012824303952 0.2775881383017788 1.0 1.0 0.0405463165390607 0.0078094686864188 0.0043697957441019 +Flavin adenine dinucleotide binding 6 24 1.9664172684997356 0.0492504303041285 7.37621359223301 27.813106796116504 0.6719710250262334 0.465219074258643 3.908755076189923 2.8788689557398657 1.0329905694282788 0.3336749641062707 1.0 0.2588687133858448 0.1215022402141297 0.0006936045596716 0.00925879907482 +Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor 5 11 1.9629640886165816 0.0496503469451432 3.8398058252427183 12.78883495145631 0.8288316105774708 0.2715528044153261 1.786836430207192 1.277729935586139 1.1940635938633195 0.228034100916913 1.0 0.0053672672920639 0.0013656945298514 1.3272125229579008e-05 0.0005987051287191 diff --git a/msigdb_gomf/metrics.json b/msigdb_gomf/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..c721e1b6ce1a4212081e526a6d6df17a0049a32e --- /dev/null +++ b/msigdb_gomf/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2454, + "annotations_size": 1306, + "title": "Average number of proteins per term", + "value": 14.02833078101072 +} \ No newline at end of file diff --git a/msigdb_gomf/paths.json b/msigdb_gomf/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..cf247ea31ac489f0e9593cfea4e1be92b992bf75 --- /dev/null +++ b/msigdb_gomf/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gomf/fragment/C340/C340_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gomf/result.tsv b/msigdb_gomf/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c14d924a3b97ceb25e9de98c307e0ddaa6fa3c76 --- /dev/null +++ b/msigdb_gomf/result.tsv @@ -0,0 +1,368 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Transporter activity 0.5869001020851053 4.039996123847591 5.345208483187314e-05 0.0674292775399389 0.0698084227904276 132 Q9Y619,O60830,Q8TB61,Q9HD20,Q99595,Q8WTV0,P08183,P21796,O15439,Q9NS69,P45880,Q8IXU6,P61421,O43772,O75306,P31930,Q9BSK2,Q14849,Q9H2D1,Q6NT16,P41440,P61916,O14925,O75964,Q9H2J7,Q8N4V1,P00403,P20674,O43676,Q93050,Q9C0H2,Q70HW3,P17900,Q9UDW1,P04062,Q9Y487,Q9UBX3,Q00169,O43681,Q99797 40 +Ion transmembrane transporter activity 0.5535079098199427 3.317474285895882 0.0009083527648872 0.6948182660604922 0.1090122238687909 77 Q9Y619,Q8TB61,Q9HD20,Q6NUK1,Q13423,P21796,O43808,O15439,P45880,P61421,O43772,P31930,O75947,Q02978,Q9H2D1,P41440,O75964,P56134,Q9H2J7,Q8N4V1,Q9HC21,P00403,P20674,Q9Y277,Q9UM00,Q93050,P55011,Q9C0H2,Q70HW3,Q9UDW1,Q9Y487,Q9UBX3,O43681 33 +Hydrolase activity acting on glycosyl bonds 0.7369585542822352 3.1467505334627215 0.0016509575495002 0.8844361834746814 0.1090122238687909 24 P17900,P06280,P04062,O60502,Q9BTY2,P16278,Q9NUJ1,O75503,P10253,Q99519 10 +Peptidase activity 0.493154891052509 3.0727811939390164 0.0021207392407731 0.9375023609170005 0.1090122238687909 98 Q9HB40,P28070,P49721,P42785,Q969V3,Q16740,Q9UIQ6,Q5JRX3,Q99436,Q9H3G5,P42892,Q92820,O43464,P28072,P55786,O43847,O75844,P10619,Q9NZ08,P20618,P60900,P22695,Q99797 23 +Hydrolase activity hydrolyzing o glycosyl compounds 0.751647314116239 2.909955545555812 0.0036148016748498 0.99116897527193 0.1090122238687909 18 P17900,P06280,P04062,O60502,Q9BTY2,P16278,Q9NUJ1,P10253,Q99519 9 +Inorganic molecular entity transmembrane transporter activity 0.5283160378870895 2.881993253065733 0.003951681949154 0.9943217981967688 0.1090122238687909 59 Q9HD20,Q13423,P21796,O15439,P45880,P61421,P31930,O75947,Q02978,O75964,P56134,Q9H2J7,Q8N4V1,P00403,P20674,Q9UM00,Q9Y277,P55011,Q93050,P12235,Q9C0H2,Q9UDW1,Q9Y487,Q9UBX3,O43681,Q99797 26 +Endopeptidase activity 0.5256742215660407 2.8292069532745123 0.0046663513099953 0.9977761562625468 0.1090122238687909 55 Q9NZ08,P28070,P28072,P49721,P20618,P60900,Q16740,O43847,O75844,P22695,O43464,Q5JRX3,Q99436,P28074,P42892,Q99797 16 +Anion transmembrane transporter activity 0.6485506917856342 2.8259231003473486 0.0047144580592728 0.997912194273756 0.1090122238687909 30 Q9Y619,P45880,P41440,Q8TB61,P55011,Q9HC21,Q6NUK1,Q02978,P21796,Q9Y277,O43808,Q9H2D1,O15439,O43681,P12235,Q9UBX3,Q9C0H2 17 +Tetrapyrrole binding 0.785891163802192 2.802107692933323 0.0050769922667321 0.998702661885424 0.1090122238687909 14 P30519,Q8WUJ1,Q9H7Z7,O43169,Q16850,P09601 6 +Exopeptidase activity 0.6480077884628921 2.7867546138369197 0.005323877629114 0.999061810455698 0.1090122238687909 29 Q9HB40,P55786,P42785,Q9UIQ6,O75844,P10619,Q9H3G5 7 +Lipid binding 0.4625351172621855 2.7711196420640816 0.005586389630751 0.9993353697804304 0.1090122238687909 100 P45880,Q14108,P28070,P60903,P07737,P61916,O94788,P04062,Q14849,Q8WTV0,Q9Y2I1,P04083,P50897,P21796,Q15067,Q9BQE5,A6NIH7 17 +Serine hydrolase activity 0.7198217046284059 2.6917215140584902 0.0071084274640031 0.9999100952151124 0.1177663791584164 17 P42785,Q9HB40,Q16740,Q9H3G5 4 +Amide binding 0.4708471475165048 2.67553651243055 0.0074609745758442 0.9999434601358586 0.1186418678206875 90 P45880,Q9NZ08,Q9Y680,Q9H7Z7,P55786,Q9NXR7,Q9UIQ6,Q8WTV0,Q08752,P00374,P21796,P40939,P24390,Q15392 14 +Nucleobase containing compound transmembrane transporter activity 0.7606433616186996 2.674155808479455 0.0074917635579692 0.9999457049725996 0.1186418678206875 14 P41440,Q8TB61,Q9BSK2,L0R6Q1,Q9HC21,Q6NUK1,O43808,Q9H2D1,P51991,O15439 10 +Steroid binding 0.7013852784335047 2.630977047728499 0.0085139785766805 0.9999858650622746 0.1233949514521509 18 P45880,Q14108,P61916,P04062,Q14849,O15173,P21796 7 +Cholesterol binding 0.8429028769304076 2.628939683392906 0.0085651551270997 0.9999867865223976 0.1233949514521509 10 Q14108,P45880,P21796,Q14849 4 +Organic acid transmembrane transporter activity 0.7181465066429598 2.6005544861501138 0.0093073237643483 0.9999950309667508 0.1284704459137584 16 Q9Y619,P41440,Q9H2J7,P08183,Q9H2D1,O15439,Q9UBX3 7 +Sterol binding 0.7490788054937361 2.5468732998146306 0.010869288872203 0.9999993671302754 0.1330394556657329 13 Q14108,P45880,P21796,Q14849 4 +Oxidoreductase activity 0.4722590272444121 2.5218058183935237 0.01167541389567 0.9999997817890116 0.1366646463383739 190 P30519,Q06136,Q9H7Z7,Q3SXM5,O14880,P14406,P40939,P09601,P48735,O15439,Q15392,Q14739,O75306,Q8N4Q0,P31930,Q16134,O75874,Q8WWV3,P13674,Q8NBX0,Q16850,Q9UHG3,P13804,P30837,O43169,P00374,P00403,Q16836,P16219,O95831,O43676,P20674,Q9UBM7,O15460,Q9UDW1,O94788,P35270,Q14914,Q8NB78 39 +Threonine type peptidase activity 0.8360118124975103 2.5204619110817696 0.0117200921821576 0.9999997942993516 0.1366646463383739 9 P28070,P28072,P20618,P49721,Q99436 5 +Peptide binding 0.4879120050808652 2.5133679888858733 0.0119584524044593 0.999999849886182 0.1369977091247713 61 Q9NZ08,Q9H7Z7,P55786,Q9UIQ6,Q8WTV0,Q08752,P24390,Q15392 8 +Alcohol binding 0.7408427926562152 2.505040037123373 0.0122437532952397 0.999999897051724 0.1377904299984826 13 Q14108,P45880,P21796,Q14849 4 +Threonine type endopeptidase activity 0.8481977032997318 2.4991354583278875 0.0124496713168613 0.9999999215912244 0.1377904299984826 8 P28070,P28072,P20618,P49721,Q99436 5 +Serine type exopeptidase activity 0.8981519133160661 2.4722137656883714 0.0134279196376194 0.9999999785098166 0.1398444148389983 7 P42785,Q9HB40,Q9H3G5 3 +Carboxypeptidase activity 0.7583843538470842 2.466156655914497 0.0136571589904437 0.999999984135252 0.1398444148389983 12 P42785,Q9HB40,Q9H3G5 3 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 0.6236971833009859 2.4524879366209515 0.0141872136357594 0.9999999921377374 0.1398444148389983 24 P30519,O15460,Q8NB78,Q16850,P09601 5 +Nucleotide transmembrane transporter activity 0.7554348879625273 2.451648175395153 0.0142203624688599 0.9999999924755458 0.1398444148389983 12 P41440,Q8TB61,Q9BSK2,Q9HC21,Q6NUK1,O43808,Q9H2D1,O15439 8 +Organophosphate ester transmembrane transporter activity 0.7554348879625273 2.451648175395153 0.0142203624688599 0.9999999924755458 0.1398444148389983 12 P41440,Q8TB61,Q9BSK2,Q9HC21,Q6NUK1,O43808,Q9H2D1,O15439 8 +Phosphatidylcholine binding 0.8371411300610554 2.4511153755260495 0.0142414296888107 0.9999999926826568 0.1398444148389983 8 Q14108,P45880,P21796 3 +Organic anion transmembrane transporter activity 0.6375678634414733 2.4371610530442767 0.0148030846935056 0.9999999965238808 0.1442748403710328 22 Q9Y619,P41440,Q8TB61,Q9HC21,Q6NUK1,Q02978,O43808,Q9H2D1,O15439,P12235,Q9UBX3 11 +Nadp binding 0.6796963752915666 2.388907503637795 0.0168985562271943 0.9999999997845116 0.148930756758065 16 P00374,Q9UBM7,O75874,Q14739 4 +Molecular transducer activity 0.6216278091660881 2.3871530277505077 0.0169794219816343 0.9999999998064614 0.148930756758065 23 Q14108,O15118,Q99523,Q9BUN8,O43813,Q8WTV0,O15173,Q15629,Q99720 9 +Serine type carboxypeptidase activity 0.9550204716533108 2.377196291714637 0.0174448020821023 0.9999999998957236 0.148930756758065 5 P42785,Q9HB40,Q9H3G5 3 +Sphingolipid binding 0.9835752341177858 2.359121704955508 0.0183182469715661 0.9999999999673592 0.1513428518623236 4 P21796 1 +Protein transporter activity 0.6996721297860227 2.356345990066395 0.0184557188359806 0.9999999999728152 0.1513428518623236 14 O60830,Q99595,O14925,Q9NS69 4 +Calcium ion binding 0.4708231385209574 2.352311960176656 0.0186571203291225 0.9999999999792062 0.1513428518623236 62 P13693,P60903,Q02818,Q9Y680,Q9BRK5,P80303,P30626,P60660,Q6NUK1,P04083,Q14257,Q9NWM8,O43852,O43681 14 +Protein transmembrane transporter activity 0.7559801230379917 2.3377973458948884 0.0193977633686011 0.9999999999922428 0.1554201163152947 11 O60830,Q99595 2 +Macromolecule transmembrane transporter activity 0.731691531469775 2.3338892592275724 0.0196015213055928 0.9999999999940866 0.1560950416164897 12 O60830,Q99595 2 +Cation transmembrane transporter activity 0.4671472866581968 2.280519968505786 0.0225768678511195 0.9999999999998884 0.174469759843563 56 Q9Y619,Q9HD20,Q13423,O43808,P61421,O43772,P31930,O75947,O75964,P56134,Q9H2J7,Q8N4V1,Q9HC21,P00403,P20674,Q9UM00,P55011,Q93050,P12235,Q70HW3,Q9UDW1,Q9Y487 22 +Lipid transporter activity 0.6794517833868735 2.248109030946414 0.0245692383600355 0.9999999999999922 0.1854764468104418 14 P17900,P61916,Q14849,P08183,O15439,Q00169 6 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen 0.991435562805872 2.2395010215982603 0.0251233349237796 0.9999999999999964 0.1874918594883209 2 P30519 1 +Monooxygenase activity 0.9124194805416044 2.2098624741086534 0.0271147082985261 0.9999999999999998 0.1967322724326396 5 P30519,P09601 2 +Exogenous protein binding 0.6693930582134588 2.1937290984179967 0.0282548906261759 1.0 0.2016441921190478 14 Q14108,P11279,Q8WTV0 3 +Growth factor receptor binding 0.6443494485240387 2.1893235507143176 0.0285733318044942 1.0 0.202808539873204 16 Q9NZ08,Q92600,P18085,P05067,Q92542,Q9H2J4,Q9Y639,P62993 8 +Quaternary ammonium group binding 0.7238937394213176 2.182184536090068 0.0290959161188466 1.0 0.2044306553354357 11 P45880,P21796 2 +Electron transfer activity 0.5135693047631052 2.1798086275767647 0.0292716501492624 1.0 0.2044319523793411 41 O75306,P13804,O15460,Q9UDW1,P31930,Q16134,P00403,P14406,O43676 9 +Inorganic anion transmembrane transporter activity 0.721035051786418 2.1681776641434967 0.0301451715540661 1.0 0.208304730421219 11 P45880,Q02978,P21796,O15439,O43681,Q9UBX3,Q9C0H2 7 +Phosphatidylserine binding 0.7514791146538923 2.137985056548042 0.0325179560880597 1.0 0.2164405124882528 9 Q8WTV0 1 +Isocitrate dehydrogenase activity 0.8873152080167173 2.10981464482015 0.0348743245356633 1.0 0.2232640580567464 5 P48735 1 +Phospholipid binding 0.4458279759612421 2.094582396613866 0.0362081314099356 1.0 0.2273452866412303 61 P45880,Q14108,P07737,Q8WTV0,P04083,P50897,P21796,Q9Y2I1,Q00169 9 +Modified amino acid binding 0.5975767843755038 2.0594712061548144 0.0394491206020624 1.0 0.241074739912486 19 Q14108,P00374,Q9H7Z7,Q8WTV0 4 +Metalloendopeptidase activity 0.6334743300656444 2.0591327097971788 0.0394815271246753 1.0 0.241074739912486 15 O43847,O75844,P22695,Q5JRX3,Q99797 5 +Galactoside binding 0.9441272430668805 2.043336950956805 0.041019094135857 1.0 0.2468706771494436 2 P16278 1 +Galactosidase activity 0.9441272430668805 2.043336950956805 0.041019094135857 1.0 0.2468706771494436 2 P16278 1 +Efflux transmembrane transporter activity 0.9384176182707996 2.0194604273797863 0.043439386376558 1.0 0.2507318192177979 2 P08183 1 +Abc type xenobiotic transporter activity 0.9384176182707996 2.0194604273797863 0.043439386376558 1.0 0.2507318192177979 2 P08183 1 +5 3 exodeoxyribonuclease activity 0.931076672104401 1.9887017360673191 0.046734134265618 1.0 0.2522098320285029 2 Q9UQ84 1 +Phospholipase d activity 0.9310766721044 1.9887017360673152 0.0467341342656184 1.0 0.2522098320285029 2 P09601 1 +Flavin adenine dinucleotide binding 0.5499401406901216 1.9664172684997352 0.0492504303041285 1.0 0.2621626082448872 24 P13804,Q16134,P16219,Q8NB78,O95831,Q15392 6 +Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor 0.6796856070530847 1.9629640886165816 0.0496503469451432 1.0 0.2621626082448872 11 Q8N4Q0,Q9H7Z7,Q14914,Q9UBM7,Q14739 5 +Cadherin binding involved in cell cell adhesion 0.6781557307939751 1.9552782401490632 0.0505502381028908 1.0 0.2651349837846402 11 Q9UQB8,Q9NYL9 2 +Folic acid transmembrane transporter activity 0.921696574225118 1.949302799794148 0.051259274432968 1.0 0.2677784496378252 2 Q9H2D1 1 +Atpase binding 0.5534129718955896 1.94334733937846 0.0519742053540253 1.0 0.2693583817157026 23 Q16740,P11233,Q93050,Q9Y487,Q9UII2 5 +Palmitoyl protein hydrolase activity 0.8755015875419456 1.935268114048615 0.0529574030341686 1.0 0.2722927888292292 4 P50897 1 +Sulfur compound transmembrane transporter activity 0.7683829027598055 1.9226692308146685 0.0545216034093012 1.0 0.2760280160122685 7 Q8TB61,Q02978,O15439,Q9UBX3,Q70HW3 5 +Cargo receptor activity 0.8410251495504664 1.9226082179878168 0.0545292711570943 1.0 0.2760280160122685 5 Q14108,Q8WTV0 2 +Protein methyltransferase activity 0.5803887446046487 1.916952977456932 0.0552439057664424 1.0 0.2784210568828603 18 Q9BV86,Q03164,O60725 3 +Purine nucleotide transmembrane transporter activity 0.7019407309467265 1.9055400682230996 0.0567099041680274 1.0 0.2826837207765033 9 P41440,Q8TB61,Q6NUK1,O43808,O15439,P12235,P12236 7 +Wide pore channel activity 0.8668971632003581 1.9007729842365364 0.0573317541155944 1.0 0.2827481002314089 4 P21796 1 +Porin activity 0.8668971632003581 1.9007729842365364 0.0573317541155944 1.0 0.2827481002314089 4 P21796 1 +Ceramide binding 0.9855194246419592 1.9004635238025571 0.057372317428272 1.0 0.2827481002314089 3 P21796 1 +Carbohydrate derivative transmembrane transporter activity 0.700291142536537 1.8976957886130803 0.0577361676676191 1.0 0.2828711232338409 9 P41440,Q8TB61,L0R6Q1,Q6NUK1,O43808,P12235,P12236 7 +Gated channel activity 0.6988035447634837 1.8906161704006827 0.0586756000785801 1.0 0.284867663555469 9 P45880,P21796 2 +Structural constituent of cytoskeleton 0.5247910964712863 1.8839568780164129 0.0595708086018829 1.0 0.2862541694113494 27 Q9BUF5,P07437,P68371 3 +G protein alpha subunit binding 0.9743746720118934 1.8580726849019604 0.0631586931824657 1.0 0.2945901903439293 3 P80303 1 +Vitamin transmembrane transporter activity 0.8213629451705584 1.842062478882854 0.0654660113617811 1.0 0.2979045673814847 5 P04062,Q9H2D1 2 +Passive transmembrane transporter activity 0.5246327238543281 1.8399921254577885 0.0657693934167917 1.0 0.2982459298692016 25 P45880,O75964,P21796,Q9C0H2 4 +Metallopeptidase activity 0.4801334079694296 1.8319545487438031 0.0669581924904241 1.0 0.302405056603351 38 Q9NZ08,P55786,Q969V3,O43847,Q9UIQ6,O75844,P22695,Q5JRX3,Q99797 9 +Transition metal ion transmembrane transporter activity 0.8931484502446921 1.8287701357051311 0.0674340506140569 1.0 0.302642165298826 2 Q8N4V1 1 +Beta n acetylhexosaminidase activity 0.8457867875855827 1.8157108325607771 0.0694147414889765 1.0 0.3083525591313039 4 P17900 1 +Lipid transfer activity 0.8141661200792236 1.812434930605721 0.0699190196275671 1.0 0.3095397953681449 5 P61916,Q14849 2 +Nad binding 0.5144151023801158 1.809569020616564 0.0703626477064232 1.0 0.3097343816680473 27 O75306,Q8IXJ6,P30837,P05091,O75874,Q13423,O60701,Q16836,P40939,P48735 10 +Lipopolysaccharide binding 0.7425237677781248 1.8090882248697533 0.0704372981281853 1.0 0.3097343816680473 7 Q8WTV0 1 +Metalloaminopeptidase activity 0.6476645378705452 1.8007347158727869 0.0717447030457327 1.0 0.3133731845408929 11 Q9UIQ6,P55786 2 +Hsp70 protein binding 0.5877919141373014 1.7969975272262055 0.0723360123250982 1.0 0.3149027736552609 15 Q08752,P37198,O75937,P46379 4 +Glucosidase activity 0.8098868597297795 1.794782212558424 0.0726884058869914 1.0 0.3153855750445541 5 P04062 1 +Fad binding 0.6752501220761781 1.7778185834888942 0.075433655337525 1.0 0.3230044389206808 9 Q8NB78,Q15392,O95831 3 +Cell cell adhesion mediator activity 0.561245273659663 1.7658655609961766 0.0774184061949341 1.0 0.3263166845640277 17 Q9UQB8,P04083,Q9NYL9 3 +Amyloid beta binding 0.6856649714744523 1.7641394091476952 0.0777085108880812 1.0 0.3263166845640277 8 Q99471,Q8WTV0,P61758 3 +Signaling receptor regulator activity 0.6016310938565244 1.763779992282921 0.0777690273026787 1.0 0.3263166845640277 13 P43490,Q9UMX5 2 +Succinate transmembrane transporter activity 0.876427406199022 1.7577777131789762 0.0787853388710233 1.0 0.3263166845640277 2 Q9UBX3 1 +Sulfate transmembrane transporter activity 0.876427406199022 1.7577777131789762 0.0787853388710233 1.0 0.3263166845640277 2 Q9UBX3 1 +Oxidoreduction driven active transmembrane transporter activity 0.5436731360784892 1.756778066976621 0.0789556449634247 1.0 0.3263166845640277 20 O75306,Q9UDW1,P31930,P00403,O43676 5 +Arylesterase activity 0.8711256117455053 1.7352137851232017 0.0827029457041921 1.0 0.3407257005983435 2 Q15165 1 +Oxidoreductase activity acting on a sulfur group of donors oxygen as acceptor 0.8242171196854136 1.7281990968378744 0.0839525356118757 1.0 0.343705365232319 4 Q9UHG3,Q6ZRP7 2 +Oxidoreductase activity acting on the ch ch group of donors 0.5248427919389852 1.7091988569808594 0.0874141205337379 1.0 0.3521196344221504 22 Q8N4Q0,Q9H7Z7,Q9UBM7,Q14914,P16219,Q15392,Q14739 7 +Proline rich region binding 0.8176072052508813 1.7012680061776122 0.0888926728409824 1.0 0.3543723900073989 4 Q9UQB8 1 +Peptidyl proline dioxygenase activity 0.7872164252554892 1.700830330902104 0.0889748520041822 1.0 0.3543723900073989 5 P13674,O15460 2 +Cell adhesion mediator activity 0.5401163534210633 1.6984984013363158 0.0894137341604393 1.0 0.3543723900073989 19 Q9UQB8,P04083,Q9NYL9 3 +Amide transmembrane transporter activity 0.7638859404302689 1.6957760201500975 0.0899283054386015 1.0 0.3543723900073989 6 O15439,Q9H2D1 2 +Organic cation transmembrane transporter activity 0.8122448979591815 1.6793830320644392 0.0930774180342108 1.0 0.3554359881657293 4 O43772,O43808,Q70HW3 3 +Metalloexopeptidase activity 0.5401895640639759 1.6659972345188223 0.095713965252056 1.0 0.3595847352442093 18 Q9UIQ6,O75844,P55786 3 +Scavenger receptor activity 0.924112607099146 1.665485968942928 0.0958158406316882 1.0 0.3595847352442093 3 Q14108,Q8WTV0 2 +Modified amino acid transmembrane transporter activity 0.922072623419015 1.6576266522880214 0.0973928466991411 1.0 0.3633624927826887 3 O15439,Q9H2D1 2 +Xenobiotic transmembrane transporter activity 0.9220726234190136 1.657626652288017 0.097392846699142 1.0 0.3633624927826887 3 O15439,P08183 2 +Protein lipid complex binding 0.920978855463789 1.6534115682063757 0.0982471301020346 1.0 0.3633624927826887 3 Q8WTV0 1 +High density lipoprotein particle binding 0.920978855463789 1.6534115682063757 0.0982471301020346 1.0 0.3633624927826887 3 Q8WTV0 1 +Mhc class i protein binding 0.6492027633237317 1.651586717690526 0.0986188295277643 1.0 0.3633624927826887 9 P07437,P68371 2 +Oxidoreductase activity acting on ch oh group of donors 0.4269984263072812 1.6300360632108306 0.1030938752567878 1.0 0.3709107467916388 48 Q8N4Q0,Q06136,O75874,P35270,Q14914,O60701,Q53GQ0,P40939,Q16836,Q8NBN7,P48735,O15439 12 +Nadph binding 0.7988253000627611 1.6244756092683803 0.1042743418063836 1.0 0.3731021654770877 4 Q14739 1 +Hexosaminidase activity 0.7681906463121456 1.621455208398484 0.1049200487474648 1.0 0.3743868406125385 5 P17900,O60502 2 +Quinone binding 0.7970845561181552 1.6173393367729656 0.1058050525455862 1.0 0.3754929310449338 4 Q16134 1 +Procollagen proline dioxygenase activity 0.7957017460127602 1.611668251556137 0.1070341499043416 1.0 0.3766265902272463 4 P13674,O15460 2 +Anion channel activity 0.743618279469788 1.6101068725389516 0.1073745270094757 1.0 0.3766265902272463 6 P45880,P21796 2 +Nadplus binding 0.7577572609560482 1.5777403813252031 0.1146252652471568 1.0 0.3933851726305753 5 Q16836,P40939 2 +Sulfuric ester hydrolase activity 0.8340130505709535 1.5766683029117283 0.1148718674284223 1.0 0.3933851726305753 2 O43681 1 +Histone methyltransferase activity 0.5854935422691376 1.570787768382547 0.1162319541641248 1.0 0.3953097191102785 12 Q9BV86,Q03164 2 +Voltage gated channel activity 0.6868412986296928 1.5603675163684962 0.118673056603312 1.0 0.4015207562795999 7 P21796 1 +Voltage gated anion channel activity 0.780268197986453 1.5482486591506972 0.1215624401768331 1.0 0.4081247991540979 4 P21796 1 +Procollagen proline 4 dioxygenase activity 0.8902488780089788 1.5346858055874173 0.1248610241606216 1.0 0.4158515257357485 3 P13674,O15460 2 +Peptidyl proline 4 dioxygenase activity 0.8902488780089788 1.5346858055874173 0.1248610241606216 1.0 0.4158515257357485 3 P13674,O15460 2 +Active transmembrane transporter activity 0.3938201219591775 1.5321428873515277 0.125487178472152 1.0 0.4159549621437325 55 P61421,P41440,O75306,Q9UDW1,Q9HD20,P31930,Q9H2J7,P08183,P00403,P20674,O43676,O15439,Q9UBX3 13 +Aminopeptidase activity 0.5497716735610512 1.5199901568621317 0.1285134495250683 1.0 0.4230289732569696 14 Q9UIQ6,P55786 2 +Palmitoyltransferase activity 0.7730189264627398 1.5183866866099789 0.1289169459083261 1.0 0.4230289732569696 4 Q5W0Z9 1 +Demethylase activity 0.6739158914910115 1.5019109203437204 0.1331201159670252 1.0 0.433041879126933 7 Q16850 1 +Steroid dehydrogenase activity 0.7387587192122176 1.4978341778806716 0.1341763385416587 1.0 0.4348245611300406 5 Q3SXM5,Q53GQ0 2 +Poly a specific ribonuclease activity 0.7125643431202193 1.4777989724727667 0.1394615935019509 1.0 0.4503814949221346 6 Q9UIV1 1 +Mhc protein binding 0.6014890178611043 1.4759725633799747 0.1399512578241031 1.0 0.4503814949221346 10 P07437,P68371 2 +Solute sodium symporter activity 0.8079119086459963 1.4647331679319353 0.1429937319622263 1.0 0.4521787262534323 2 Q9H2J7 1 +Phosphotransferase activity phosphate group as acceptor 0.6214494913801051 1.4575135857881774 0.1449746639349141 1.0 0.454939607613786 8 Q14168,P23919,P15531 3 +Nadh dehydrogenase activity 0.5390400147353455 1.4572724369375851 0.1450411921294263 1.0 0.454939607613786 14 O95831,O43676 2 +3 hydroxyacyl coa dehydrogenase activity 0.7073881292394132 1.4556370430639294 0.1454929821533745 1.0 0.454939607613786 6 Q16836,P40939 2 +G protein activity 0.5643242773972245 1.4552193627315475 0.1456085420999713 1.0 0.454939607613786 12 P61020,P11233 2 +Phosphoric diester hydrolase activity 0.617575595900095 1.438777786066071 0.1502134921342031 1.0 0.4648787221025337 8 P09601 1 +Solute anion antiporter activity 0.7172618448748065 1.4070175243870977 0.1594221923794418 1.0 0.4766346271463784 5 Q02978,P41440,P12235 3 +Atp transmembrane transporter activity 0.7129740332883363 1.3888610504942869 0.164875006423804 1.0 0.4811330856709351 5 Q6NUK1,P12235,O43808 3 +Thiolester hydrolase activity 0.5509168936895068 1.3814877343654373 0.1671290465876165 1.0 0.4811330856709351 12 P50897 1 +Sterol transfer activity 0.8464581256921336 1.364846661009018 0.1723012496759466 1.0 0.4811330856709351 3 Q14849 1 +Primary active transmembrane transporter activity 0.4207157552969637 1.3647413625839269 0.1723343543923932 1.0 0.4811330856709351 40 P61421,O75306,Q9UDW1,P31930,P08183,P00403,P20674,O43676,O15439 9 +Phosphatidylcholine transporter activity 0.8462983541217695 1.364226468758467 0.172496300108621 1.0 0.4811330856709351 3 P08183 1 +Phospholipid transporter activity 0.8462983541217697 1.364226468758467 0.172496300108621 1.0 0.4811330856709351 3 P08183 1 +Phosphatidylinositol bisphosphate phosphatase activity 0.7838499184339339 1.3614541929357586 0.1733702000597481 1.0 0.4811330856709351 2 Q9Y217 1 +Rna strand annealing activity 0.7059868413720406 1.3592497288861958 0.1740674680219833 1.0 0.4811330856709351 5 P23588,Q15056,Q06787 3 +Peptide receptor activity 0.7826264274061879 1.3562045824222495 0.1750340844330802 1.0 0.4811330856709351 2 Q99720 1 +Collagen binding 0.6404537580975114 1.3495637218424092 0.1771559675752196 1.0 0.4811330856709351 7 O75718,Q92791 2 +Oxidoreductase activity acting on a sulfur group of donors disulfide as acceptor 0.7773246329526958 1.3334614622803949 0.1823804141653719 1.0 0.4812790245222431 2 Q8IXB1 1 +Snap receptor activity 0.5951795140261619 1.3300406699116325 0.1835048717636325 1.0 0.4819482541437848 8 Q9UNK0,P51809,O95721 3 +Insulin like growth factor receptor binding 0.7756933115823815 1.3264655667191476 0.1846855333195289 1.0 0.4820347340716429 2 P61981 1 +Minor groove of adenine thymine rich dna binding 0.7184183191976661 1.292425619918247 0.1962097890348975 1.0 0.4973048671599749 4 Q03164,Q14103 2 +Cytokine receptor binding 0.4856763827143618 1.2894361688225449 0.1972464940190406 1.0 0.4973048671599749 17 Q9NZ08,Q9NXR7,P62993,Q9H2J4 4 +Proton transmembrane transporter activity 0.4322807900534156 1.2783424604089737 0.2011287026406742 1.0 0.503207060629733 31 P61421,Q9UDW1,P31930,O75964,P00403,Q93050,Q9Y487 7 +Oxidoreductase activity acting on other nitrogenous compounds as donors 0.7061914802255016 1.241705297738033 0.2143453146090799 1.0 0.5222667553721239 4 Q5VT66,O43169 2 +Oxidoreductase activity acting on a heme group of donors 0.6771850639922747 1.2369705050695436 0.2160980328611448 1.0 0.524542367538615 5 P00403,P16435,P20674 3 +Exonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters 0.4506307847310362 1.2320723894586263 0.2179220442422711 1.0 0.525103671181561 23 Q9UIV1,Q9Y2L1,Q96GM8,Q8IV08,Q9UQ84 5 +Folic acid binding 0.8099243257302474 1.223154673400362 0.2212712817245195 1.0 0.531213775610703 3 P00374 1 +Transferase activity transferring alkyl or aryl other than methyl groups 0.4708692765868816 1.218843367399184 0.2229036478913688 1.0 0.5331724618060948 18 Q96EY8,O43813,O14880,P49366,Q9BQC3,P78417,O00116 7 +Copper ion binding 0.6481737483168828 1.2006193379430663 0.2298988962358601 1.0 0.5470025405798741 6 O60888,P00403 2 +Adp transmembrane transporter activity 0.6962572999012917 1.2005079954083286 0.2299421093249241 1.0 0.5470025405798741 4 P12235,O43808 2 +Dicarboxylic acid transmembrane transporter activity 0.6461360616734958 1.1918156565858886 0.2333335353496344 1.0 0.5530555302479538 6 Q02978,P41440,Q9UBX3 3 +Active ion transmembrane transporter activity 0.4149207922570064 1.185575092615201 0.2357901433306819 1.0 0.5547271234906211 33 P61421,P41440,Q9UDW1,P31930,Q9HD20,Q9H2J7,P00403,P20674,O15439 9 +Nucleoside diphosphate kinase activity 0.687801524619234 1.1654657031361189 0.2438305352029304 1.0 0.5586713666228545 4 P15531 1 +Translation repressor activity 0.5603619958532944 1.1599487100932544 0.2460696890389431 1.0 0.5608499369718319 8 P00374,Q14011,Q00577,Q06787 4 +Cyclic nucleotide binding 0.6852191115178907 1.1547701701583233 0.2481845556459951 1.0 0.5628767762801341 4 P41440 1 +Phosphotyrosine residue binding 0.7918596020548695 1.1533202285655917 0.248778970253948 1.0 0.5630298332574841 3 P07737 1 +Dna clamp loader activity 0.5957427833247367 1.144511587781788 0.2524115350235307 1.0 0.5641803505710657 7 P35250 1 +Trna guanine methyltransferase activity 0.681779328569939 1.140529470378374 0.2540657820859981 1.0 0.5662285177548013 4 O75648 1 +Single stranded dna exodeoxyribonuclease activity 0.6795164091738155 1.131164992370375 0.2579856534452505 1.0 0.5722690178810387 4 Q9UQ84 1 +5 3 exonuclease activity 0.5917679728052105 1.12625102293374 0.2600592822000593 1.0 0.5746826100732276 7 Q9UQ84 1 +G protein coupled receptor activity 0.7829457364341149 1.1189603430054382 0.2631570577032982 1.0 0.5762963663725118 3 Q99720,O43813 2 +Sterol transporter activity 0.5896140107855412 1.1163561165052944 0.264269729848869 1.0 0.5762963663725118 7 P61916,Q14849 2 +Nucleoside monophosphate kinase activity 0.5867213222884871 1.1030688500407602 0.2699972669908999 1.0 0.5799526345369153 7 Q14168,P23919 2 +Vitamin d receptor binding 0.7780217513139124 1.1000152743522278 0.2713254668469029 1.0 0.5799526345369153 3 Q9Y2W1 1 +Abc type transporter activity 0.5813148660534473 1.0782408219787822 0.2809262986983261 1.0 0.5915475411465346 7 O15439,P08183 2 +Ionotropic glutamate receptor binding 0.6169737329483491 1.0658809027657643 0.2864774828590195 1.0 0.5976670808528427 6 Q13501 1 +Cis trans isomerase activity 0.4305619316330403 1.0568510170730592 0.2905795865415055 1.0 0.6025137241225997 22 Q9Y680,Q08752 2 +Oxidoreductase activity acting on the ch nh group of donors 0.5336715133127642 1.029254752156198 0.3033599797010162 1.0 0.6219593932331667 8 Q16134 1 +Pentosyltransferase activity 0.4722996389606262 1.0234686416191343 0.3060863191985041 1.0 0.6239097829759468 13 P43490 1 +Cardiolipin binding 0.6986133768352364 0.998904982900749 0.3178407221625985 1.0 0.6415764809031741 2 Q9UJZ1 1 +Guanyl nucleotide binding 0.3281156621161647 0.995497367948058 0.3194944237667898 1.0 0.6428657941427652 92 Q8IWA4,P41440,Q9BUF5,O95140,Q3YEC7,Q9BVA1,P18085,P61020,P07437,Q9NTK5,P62820,P15531,P40616,P11233,Q9BW83,P55010,P68371 17 +Signaling receptor binding 0.3382005226528392 0.9943355071089556 0.3200595547078497 1.0 0.6428657941427652 139 Q92600,P06280,P08236,P46379,Q03001,P07237,Q9Y639,Q9BQE5,Q9UJZ1,Q13501,P26583,P20073,P08754,Q9NUQ9,P05067,Q04917,Q9NXR7,Q9H2J4,P07437,P43490,P78536,P11233,P62993,P68371,P41440,P18085,Q13573,O43813,P04083,Q96J02,Q9NZ08,P17096,Q9BUN8,Q92542,P61981,Q9UMX5,P30626,P04062,Q07021,P04899,Q9Y2I1 41 +Misfolded protein binding 0.5074410454934171 0.9935368194404148 0.3204484165290506 1.0 0.6428657941427652 10 Q8IXB1,P46379,Q9BUN8,P48723 4 +Nedd8 specific protease activity 0.7470420236638091 0.9815774125631624 0.3263080797221596 1.0 0.6486799877417991 3 Q9BT78,Q92905 2 +Hormone binding 0.5973693486563529 0.9814851920095886 0.3263535332222873 1.0 0.6486799877417991 6 O43847 1 +Aspartic endopeptidase activity intramembrane cleaving 0.6933115823817331 0.9767565959169984 0.3286896687858491 1.0 0.6486799877417991 2 Q92542 1 +Steroid dehydrogenase activity acting on the ch oh group of donors nad or nadp as acceptor 0.6419793800125133 0.9765608980785798 0.328786585241186 1.0 0.6486799877417991 4 Q53GQ0 1 +Exoribonuclease activity 0.4281216636964442 0.9595660617709352 0.3372736566224181 1.0 0.656982017123273 19 Q15024,Q9UIV1,Q9Y2L1,Q9NQT5,Q96GM8,Q96C86,Q9Y3B2 7 +Thiol oxidase activity 0.7406488661426018 0.9573389587085188 0.3383961974243568 1.0 0.6576568955895982 3 Q6ZRP7 1 +Actin monomer binding 0.6073427833383094 0.9413459996221404 0.3465275769443161 1.0 0.6654830356355382 5 Q9UHB6 1 +Lipase binding 0.6847471451876068 0.941140877513352 0.3466326698207096 1.0 0.6654830356355382 2 Q96CS3 1 +Retromer complex binding 0.628979591836731 0.9235032887753832 0.3557449872979685 1.0 0.6708069557252143 4 O60493,P51149,Q99523 3 +Macrolide binding 0.582530789339679 0.9179048829232448 0.3586686650548856 1.0 0.6720851412500525 6 Q00688,Q96AY3,Q9Y680 3 +Fk506 binding 0.582530789339679 0.9179048829232448 0.3586686650548856 1.0 0.6720851412500525 6 Q00688,Q96AY3,Q9Y680 3 +Epidermal growth factor receptor binding 0.6007585936001404 0.9137644409393924 0.3608406348808683 1.0 0.6736252413567364 5 P62993,P18085 2 +Mrna 3 utr au rich region binding 0.4914684365106221 0.91139656653059 0.3620864620462702 1.0 0.6736252413567364 10 Q13151,P31483,Q01085 3 +Nadplus kinase activity 0.6761827079934692 0.9057470999818172 0.3650697264896876 1.0 0.6782091931657639 2 Q4G0N4 1 +Complement component c1q complex binding 0.6749592169657439 0.9007104440875827 0.3677422941856629 1.0 0.6786318297332156 2 Q07021 1 +Oxidoreductase activity acting on other nitrogenous compounds as donors cytochrome as acceptor 0.7255438834601688 0.9004226786052487 0.3678953563944231 1.0 0.6786318297332156 3 O43169 1 +Nitrite reductase activity 0.7255438834601688 0.9004226786052487 0.3678953563944231 1.0 0.6786318297332156 3 O43169 1 +Ubiquitin ligase substrate adaptor activity 0.7238687232200967 0.8941441705066183 0.3712447588002909 1.0 0.6794832889594868 3 O75340 1 +Protein kinase a regulatory subunit binding 0.5938751284176427 0.8850234071712388 0.3761440070019906 1.0 0.6813371333489593 5 P17612,Q9H3P7,Q9ULX6 3 +N methyltransferase activity 0.4419109644630982 0.8797790953194572 0.3789789914232409 1.0 0.6836278491695478 14 Q03164,O96028 2 +Amino acid transmembrane transporter activity 0.5010881680293803 0.870377323654758 0.3840942348793039 1.0 0.6871603708936588 8 Q9Y619 1 +Ubiquinol cytochrome c reductase activity 0.716457397788005 0.8664552134232402 0.3862405767024306 1.0 0.6873603293144723 3 Q9UDW1 1 +Oxidoreductase activity acting on diphenols and related substances as donors 0.716457397788005 0.8664552134232402 0.3862405767024306 1.0 0.6873603293144723 3 Q9UDW1 1 +Glutamate receptor binding 0.4979524630235509 0.8551778644192249 0.3924526886054913 1.0 0.6938166788005239 8 Q13501 1 +Phosphatidic acid binding 0.6635399673735759 0.8539596121979937 0.3931273677736506 1.0 0.6938166788005239 2 O60313 1 +C4 dicarboxylate transmembrane transporter activity 0.5854905624024472 0.8501627797570908 0.3952345918819766 1.0 0.694719215340325 5 Q02978,Q9UBX3 2 +Iron ion binding 0.4134783937953266 0.8403925945518418 0.400688299913009 1.0 0.6970030320744806 18 O15460,Q16850 2 +Exoribonuclease activity producing 5 phosphomonoesters 0.4212891409057541 0.829057185925897 0.4070720488721708 1.0 0.7022933894677083 16 Q9Y2L1,Q9UIV1,Q96GM8 3 +Lipase inhibitor activity 0.7034896106735193 0.8183867564872472 0.4131363814477069 1.0 0.7071886082922727 3 P04083 1 +Transforming growth factor beta receptor binding 0.6521207177814068 0.8077216729445059 0.4192508242685631 1.0 0.7075681674072637 2 Q96AC1 1 +Type i transforming growth factor beta receptor binding 0.6521207177814068 0.8077216729445059 0.4192508242685631 1.0 0.7075681674072637 2 Q96AC1 1 +Phosphatidylglycerol binding 0.7002693347613949 0.8065317559520946 0.4199363052054834 1.0 0.7075681674072637 3 Q00169 1 +Gtpase activity 0.3241215961342226 0.7909848444384109 0.4289528355093637 1.0 0.7163841472829016 67 Q8IWA4,Q9BUF5,O95140,P18085,Q9BVA1,P61020,P07437,P62820,P40616,P11233,Q9BW83,P68371 12 +Glutathione transferase activity 0.5174394720886001 0.7873504314906711 0.431076755125918 1.0 0.7170962914296019 7 O14880,O43813 2 +Glucocorticoid receptor binding 0.6455954323001629 0.7815572465041055 0.4344748210405063 1.0 0.7173503366357791 2 Q04917 1 +Carbon nitrogen lyase activity 0.685693219601537 0.7533261445668671 0.4512539517626903 1.0 0.7330070410473553 3 Q9HDC9 1 +Secondary active transmembrane transporter activity 0.4139706948078349 0.7462957953585001 0.4554887508207188 1.0 0.7375793657261371 15 P41440,Q9H2J7,Q02978,P55011,Q9UBX3 5 +G protein beta gamma subunit complex binding 0.6771062613093392 0.7223634154826346 0.470071073432708 1.0 0.7551462746782506 3 P04899 1 +Trna methyltransferase activity 0.5543045850778674 0.7223371314304918 0.4700872291833213 1.0 0.7551462746782506 5 O75648 1 +Rage receptor binding 0.6288743882544799 0.7154781626313138 0.4743136297771295 1.0 0.758850015142716 2 P26583 1 +Transmembrane receptor protein kinase activity 0.6284665579119131 0.713885320474729 0.4752980952425281 1.0 0.758850015142716 2 Q15375 1 +Transmembrane receptor protein tyrosine kinase activity 0.6284665579119131 0.713885320474729 0.4752980952425281 1.0 0.758850015142716 2 Q15375 1 +Exodeoxyribonuclease activity 0.4592567033501075 0.7069995925491073 0.4795667309929901 1.0 0.7647303427067705 9 Q9UQ84 1 +Protein serine threonine kinase inhibitor activity 0.5274695764316857 0.686412279608431 0.4924531631650708 1.0 0.773872522040062 6 P04792,P10644 2 +Magnesium ion binding 0.315075206050416 0.6809627769225023 0.4958950438214486 1.0 0.7743896695683111 63 P48735,Q9H773,Q969T7 3 +Protein disulfide isomerase activity 0.4611408395862599 0.6789424467136744 0.4971743293567203 1.0 0.7743896695683111 8 Q6ZRP7,P30040,P07237 3 +Calcium dependent cysteine type endopeptidase activity 0.619086460032632 0.6775200537153125 0.4980760508708892 1.0 0.7743896695683111 2 P17655 1 +Hsp90 protein binding 0.3881934274821162 0.6584771806706569 0.5102315554245724 1.0 0.7819649727310563 17 P37198,Q08752 2 +Poly a binding 0.4290406348008733 0.6464403044529872 0.5179942454807338 1.0 0.787315982516457 11 O14979 1 +Protein phosphorylated amino acid binding 0.5175229813624291 0.645741203303812 0.518446971641771 1.0 0.787315982516457 6 P07737 1 +Lysine n methyltransferase activity 0.5160686328958144 0.6398338905207512 0.522280596972561 1.0 0.7893934288332636 6 Q03164 1 +Histone lysine n methyltransferase activity 0.5160686328958144 0.6398338905207512 0.522280596972561 1.0 0.7893934288332636 6 Q03164 1 +Oxidoreductase activity acting on a sulfur group of donors 0.3740149046764364 0.6361090735425189 0.5247053319138906 1.0 0.7912992649879228 21 Q8IXB1,Q9UHG3,Q6ZRP7,P07237 4 +Opsonin binding 0.647082823337418 0.6167446701488597 0.5374031521706593 1.0 0.7993718869417779 3 P27797,Q07021 2 +Complement binding 0.647082823337418 0.6167446701488597 0.5374031521706593 1.0 0.7993718869417779 3 P27797,Q07021 2 +Aldehyde dehydrogenase nad p plus activity 0.4780875214830192 0.6137585557081628 0.5393748877644984 1.0 0.7999274282992987 7 O94788,P51648,P30837 3 +Fatty acid binding 0.5474639491616367 0.6027433468597233 0.5466794403289241 1.0 0.8029347736667093 4 Q15067 1 +Bubble dna binding 0.5986949429037591 0.6004299353308717 0.5482197424028161 1.0 0.8029347736667093 2 P09429 1 +G rich strand telomeric dna binding 0.6419375023842857 0.5991134957209848 0.5490972026499641 1.0 0.8030469727445163 3 P22626 1 +Myosin v binding 0.6385148918808702 0.5874701411627327 0.5568879982776744 1.0 0.8117139796324139 3 P61006,P61106 2 +Phosphoric ester hydrolase activity 0.3311801622184546 0.585387645448327 0.5582870940380407 1.0 0.8119409185007584 42 Q969T7,Q8IV08,P11117,Q14738,P09601 5 +Polyubiquitin modification dependent protein binding 0.4162956089250441 0.5809094043359802 0.561301513782267 1.0 0.812458432443434 11 Q9NXR7,Q13501 2 +Growth factor binding 0.4155986529086619 0.5773557985653612 0.5636991271456719 1.0 0.812458432443434 11 O43847 1 +Solute cation symporter activity 0.5405785631323777 0.5770770819922045 0.5638873853851236 1.0 0.812458432443434 4 P55011,Q9H2J7 2 +Protein binding involved in heterotypic cell cell adhesion 0.6352509179926586 0.5764315451821792 0.5643235274821701 1.0 0.812458432443434 3 P15924,P14923 2 +Cell adhesive protein binding involved in bundle of his cell purkinje myocyte communication 0.6352509179926586 0.5764315451821792 0.5643235274821701 1.0 0.812458432443434 3 P15924,P14923 2 +L ascorbic acid binding 0.4679617290939928 0.5703474394750994 0.5684420710832585 1.0 0.8140190184591398 7 O15460 1 +Antiporter activity 0.4291107772539029 0.562282774244056 0.573923372777772 1.0 0.8182793939386138 9 Q02978,P41440,Q9UBX3 3 +Chemoattractant activity 0.6299511786423492 0.558647840062364 0.5764020835955919 1.0 0.8187214974270827 3 P26583 1 +4 iron 4 sulfur cluster binding 0.3712261953675557 0.5508515654581321 0.5817354321236268 1.0 0.8187214974270827 17 Q16134,O75306 2 +Exonuclease activity 0.3426652532307318 0.5467421501567622 0.5845558919087113 1.0 0.8189754769171723 30 Q15024,Q9UIV1,Q9Y2L1,Q9NQT5,Q96GM8,Q8IV08,Q96C86,Q9Y3B2,Q9UQ84 9 +Nuclear receptor binding 0.3462641073959576 0.5451570748923215 0.5856454911671347 1.0 0.8189754769171723 27 P17096,Q9UIF9,Q08752,Q969G3,Q9Y2W1 5 +Proton channel activity 0.418317627474548 0.5443995941679689 0.5861665250137298 1.0 0.8189754769171723 10 O75947,P24539,O75964,P56134 4 +Proton transporting atp synthase activity rotational mechanism 0.418317627474548 0.5443995941679689 0.5861665250137298 1.0 0.8189754769171723 10 O75947,P24539,O75964,P56134 4 +Myosin binding 0.4248625979856534 0.5423456476439767 0.587580414909181 1.0 0.8189754769171723 9 O14745,P61106,P11233 3 +Translation repressor activity mrna regulatory element binding 0.4894032983110322 0.5336119361292585 0.5936100483707467 1.0 0.8231565038024603 6 P00374,Q00577 2 +Poly purine tract binding 0.3828613918294758 0.5334363405618309 0.5937315670611927 1.0 0.8231565038024603 14 Q96EP5,O14979 2 +Metal ion transmembrane transporter activity 0.3617085425071976 0.5183768472194745 0.6041953653498369 1.0 0.8309990169649054 19 Q9H2J7,Q8N4V1,Q9HD20 3 +Adenylate kinase activity 0.61729906160751 0.5169315564462948 0.6052039380626124 1.0 0.8311212861301491 3 P54819,Q9Y3D8 2 +Oligopeptide binding 0.4899112429496269 0.473167846931119 0.6360934350880014 1.0 0.8535629282899926 5 Q9H7Z7 1 +Peptide transmembrane transporter activity 0.6024284755758335 0.4693449765688172 0.6388230714921947 1.0 0.8540594589464428 3 O15439 1 +Mannosyltransferase activity 0.6014917064951613 0.4664031333439743 0.6409269691083486 1.0 0.8540594589464428 3 Q6ZXV5 1 +Aldo keto reductase nadp activity 0.4428185611688234 0.4656319703924073 0.6414789548142275 1.0 0.8540594589464428 7 P35270 1 +Glycosyltransferase activity 0.3228616350465448 0.4620076661776279 0.6440758228959991 1.0 0.8548404722583077 36 Q6ZXV5,Q8IXJ6,O75340,Q13126,P04062,P43490,Q10472 7 +Transmembrane transporter binding 0.3356662915298196 0.4600673871923351 0.6454678520322632 1.0 0.8558182890904931 26 P60903,P30626,P21796 3 +Ubiquitin binding 0.3389998798109044 0.4563937242123762 0.6481068778312131 1.0 0.8570849486238051 24 Q96CS3,Q8IXJ6,P04792,Q9UNZ2,Q9Y679,Q9Y263,P54727,Q99816,P37198,Q13501 10 +Sh2 domain binding 0.4686314989795506 0.4541727189579307 0.6497045169506639 1.0 0.8570849486238051 6 Q13501 1 +Dopamine receptor binding 0.4842792976725225 0.4527361201377259 0.6507387669370104 1.0 0.8575830773155758 5 Q96QK1,O14745,P50570,Q14344 4 +Glyceraldehyde 3 phosphate dehydrogenase nadplus non phosphorylating activity 0.4827781389363836 0.4473361836234406 0.6546323452372822 1.0 0.860976679637352 5 P51648,P30837 2 +Heparin binding 0.3941229713689634 0.4300820082709875 0.6671359871957918 1.0 0.8730256505788618 10 O14737,P05067 2 +Atpase activator activity 0.3845217234795816 0.4229432972421619 0.6723366320100532 1.0 0.8745733480130773 11 Q8IXB1,Q99543 2 +Molecular function activator activity 0.3845217234795816 0.4229432972421619 0.6723366320100532 1.0 0.8745733480130773 11 Q8IXB1,Q99543 2 +Gtp dependent protein binding 0.4582657263997632 0.415847820811298 0.6775213635274919 1.0 0.8752155299375909 6 P61020 1 +Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amides 0.3881004094910528 0.402514449155225 0.6873054566793664 1.0 0.8826164468271903 10 Q13510 1 +Calcium dependent protein binding 0.3429759106935684 0.3772170676442929 0.7060122974502754 1.0 0.8982714078725891 17 P20073,O75340,P60903,P04083,Q99816 5 +Cation channel activity 0.3472163915579164 0.3767300570921292 0.7063742234955199 1.0 0.8982714078725891 16 O75947,O75964,P56134,P24539,Q9UM00 5 +Acetylglucosaminyltransferase activity 0.4784163954678356 0.3618048571514355 0.7174978622275026 1.0 0.9059308177496888 4 O43505 1 +Poly g binding 0.4571661553535126 0.3584813079529773 0.7199831537721177 1.0 0.9059308177496888 5 Q96EP5,O14979 2 +Guanyl nucleotide exchange factor activity 0.3211490561905806 0.3556557681268917 0.7220983737634616 1.0 0.9073001957462976 26 P80303 1 +Long chain fatty acid transporter activity 0.525693311582393 0.3539645979342236 0.7233654145867037 1.0 0.9075074269454706 2 P28288 1 +Mirna binding 0.3610405290011265 0.349329119299806 0.7268422397399568 1.0 0.907510482887556 12 P22626,P09651,Q06787,Q9BWF3,Q8IWR0 5 +Heat shock protein binding 0.2987780736767099 0.3390600602536928 0.7345644854307765 1.0 0.912390424481447 46 Q99543,Q8WXX5,O75937,P55011,P46379,Q08752,Q15785,Q8IXB1,Q15185,Q00059,P37198 11 +Ribonuclease activity 0.3052859788788776 0.319959176462532 0.7489992774892609 1.0 0.9140351107081148 37 O00584,Q9UIV1,Q9Y2L1,Q96GM8,Q9UQ84 5 +Oxidoreductase activity acting on paired donors with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 0.5134584013050628 0.3183900961578281 0.7501890498383357 1.0 0.9140351107081148 2 O00767 1 +Phosphatidylinositol 3 kinase binding 0.5097879282218719 0.3080940396808578 0.7580107764364488 1.0 0.9183321651447144 2 O14654 1 +Nucleobase containing compound kinase activity 0.3490700432235207 0.2920081162360288 0.770280418433269 1.0 0.926055680536354 12 Q14168,P15531 2 +Dna secondary structure binding 0.3548509388594369 0.2854739525226101 0.7752810573755113 1.0 0.926055680536354 11 Q03164,Q14103 2 +Acyl coa binding 0.3612076374729141 0.2848864009089024 0.7757311749668998 1.0 0.926055680536354 10 P40939 1 +Fatty acid derivative binding 0.3612076374729141 0.2848864009089024 0.7757311749668998 1.0 0.926055680536354 10 P40939 1 +Nuclear import signal receptor activity 0.3562569018314514 0.2643518440078274 0.791508814862228 1.0 0.9373339574766586 10 Q9UI26 1 +Glycosaminoglycan binding 0.3325920079597431 0.2613906870693118 0.7937912381081045 1.0 0.9373339574766586 14 O14737,Q53GQ0,P15586,P05067 4 +Hexosyltransferase activity 0.3071144956797864 0.2558511169688967 0.7980658015029922 1.0 0.941530204844542 25 Q6ZXV5,O75340,Q13126,P04062,Q10472 5 +Chaperone binding 0.2987749980150089 0.2507131269326167 0.8020359109418354 1.0 0.9432780774487928 34 Q14108,Q8WXX5,Q15185,P55011,O75347,Q7L5D6,Q13217,O43808,Q8IXB1,O60884 10 +Adrenergic receptor binding 0.5236059875186173 0.249906835556503 0.8026593969129272 1.0 0.9432780774487928 3 Q07021 1 +Peptide antigen binding 0.4076920472753291 0.2449305561590405 0.8065102017538821 1.0 0.9432780774487928 6 Q15392,P10321 2 +Metal cluster binding 0.3054167319647812 0.2444677042238964 0.8068686115505719 1.0 0.9432780774487928 25 Q16134,O75306 2 +D1 dopamine receptor binding 0.4836867862969126 0.2401798142325716 0.8101908616446434 1.0 0.9432780774487928 2 Q96QK1 1 +Beta 2 adrenergic receptor binding 0.4836867862969026 0.2401798142325476 0.810190861644662 1.0 0.9432780774487928 2 O14745 1 +Myosin ii binding 0.4836867862969026 0.2401798142325476 0.810190861644662 1.0 0.9432780774487928 2 O14745 1 +Acetylcholine receptor binding 0.4836867862969007 0.240179814232543 0.8101908616446656 1.0 0.9432780774487928 2 O15258 1 +Antigen binding 0.3819955038748719 0.2383295569835418 0.811625498555693 1.0 0.9432780774487928 7 Q15392,P10321 2 +N acyltransferase activity 0.3373389111901711 0.2380712289794052 0.8118258491978891 1.0 0.9432780774487928 12 Q96G23,Q86UY6 2 +Chloride channel inhibitor activity 0.4816476345840199 0.235279865916175 0.8139915212136193 1.0 0.9438247861357544 2 Q9UNK0 1 +Mitochondrial ribosome binding 0.5133008565543365 0.2260719861229776 0.8211454324122822 1.0 0.9473638999385516 3 Q92552 1 +Nedd8 transferase activity 0.4763458401305078 0.222823972060955 0.8236725100065199 1.0 0.9479283472173828 2 Q8TBC4 1 +2 oxoglutarate dependent dioxygenase activity 0.3244336579729946 0.2208803716926937 0.825185581093222 1.0 0.9479283472173828 14 P13674,O15460 2 +Sodium ion transmembrane transporter activity 0.3996720497135385 0.2207355849895762 0.8252983219871024 1.0 0.9479283472173828 6 P55011,Q9H2J7 2 +Mhc class ib protein binding 0.5094068252746925 0.2173934751900866 0.8279017156637707 1.0 0.9481618785349024 3 Q9NUQ9 1 +S100 protein binding 0.3520032706459546 0.2144107750347698 0.8302267397828533 1.0 0.948195119747998 8 P07355,P50995,Q09666,P31949,P16615,Q9HB71,P15311 7 +Deoxyribonuclease activity 0.3206284031051456 0.2139599781736524 0.8305782672218298 1.0 0.948195119747998 15 Q8IV08,Q9UQ84 2 +Phosphatidylinositol phosphate phosphatase activity 0.5045201330855263 0.2067614865810569 0.8361961354211935 1.0 0.9501865688443416 3 Q9Y217 1 +Vitamin binding 0.290733588988032 0.2052003770885267 0.837415574839079 1.0 0.9501865688443416 38 O15460,O94788,P04062,P00374,P13674 5 +Carboxylic acid binding 0.2964869221203704 0.2005160769302897 0.8410769857424563 1.0 0.9518625276135204 30 P41440,O15460,P00374,P13674,Q15067 5 +3 5 exonuclease activity 0.3068972692863975 0.2005133221166276 0.84107914001991 1.0 0.9518625276135204 21 Q9UIV1,Q9Y2L1,Q96GM8 3 +Long chain fatty acyl coa binding 0.4645187601957582 0.1965354504442216 0.8441910882438983 1.0 0.9537314543655114 2 O00154 1 +Transcription coregulator binding 0.3131386803713785 0.1895927478119678 0.8496282705467189 1.0 0.9553831367198764 16 Q9UQB8,Q13185,Q00059,P17096 4 +Oxidoreductase activity acting on the ch nh2 group of donors 0.4596247960848301 0.1862697432310035 0.8522332336073364 1.0 0.9554742049633452 2 P00367 1 +Symporter activity 0.3841894248404228 0.1766465375604928 0.8597860371645805 1.0 0.9613703463501216 6 Q9H2J7 1 +Atpase coupled transmembrane transporter activity 0.3036799596423122 0.1729557009033464 0.8626862483304745 1.0 0.9637880584427714 20 O15439,P08183,P61421 3 +Single stranded telomeric dna binding 0.4066360743458576 0.1654665311012189 0.8685767909969331 1.0 0.9687116046473054 4 P22626 1 +Chloride channel regulator activity 0.4818441452468437 0.1612766362946406 0.8718755239001699 1.0 0.969690469963538 3 Q9UNK0,O14745 2 +Transferase activity transferring sulphur containing groups 0.4037668261838342 0.1590887037394538 0.8735989879851598 1.0 0.969690469963538 4 O75648 1 +Structural constituent of eye lens 0.4793985258560667 0.1567554656335683 0.8754375721164678 1.0 0.9702308022969148 3 Q99797 1 +Map kinase phosphatase activity 0.4420880913539993 0.1524586526690709 0.8788251995421921 1.0 0.9718422613057602 2 Q99956 1 +Protein tyrosine serine threonine phosphatase activity 0.4420880913539993 0.1524586526690709 0.8788251995421921 1.0 0.9718422613057602 2 Q99956 1 +Dioxygenase activity 0.3024096532683112 0.1489835964439195 0.8815665766430858 1.0 0.973225654349848 17 O15460,O00625,P16435,P07237,P13674 5 +Monosaccharide binding 0.2886332200047665 0.1358323198048613 0.8919538403332605 1.0 0.9797238986335056 26 O75503,O15460 2 +Molecular carrier activity 0.2881735507680829 0.1329108077740928 0.8942639193736772 1.0 0.9806118209084992 26 Q92973,Q8N4V1,Q9UI26 3 +Phosphatidylethanolamine binding 0.3885714285714243 0.1273735248070181 0.8986447696869913 1.0 0.981449469038258 4 P30086,Q9BSJ8,P50995 3 +Nuclear receptor coactivator activity 0.3027721979456365 0.1272565050611611 0.8987373842853461 1.0 0.981449469038258 15 Q92600,P17096,Q99816,Q9Y2W1,Q96PK6 5 +Chemokine binding 0.4622603019175925 0.1271959992500631 0.8987852717991947 1.0 0.981449469038258 3 Q9ULM6,P09429 2 +Extracellular matrix binding 0.4622603019175875 0.127195999250055 0.8987852717992011 1.0 0.981449469038258 3 O94813,P08865 2 +Laminin binding 0.4622603019175875 0.127195999250055 0.8987852717992011 1.0 0.981449469038258 3 O94813,P08865 2 +C3hc4 type ring finger domain binding 0.4614443084455355 0.125881363343481 0.8998258352101143 1.0 0.9817648628107012 3 P0DMV9,P31689 2 +Sequence specific single stranded dna binding 0.3725842849627703 0.1222218905304211 0.9027232902862876 1.0 0.9824638475949096 5 P22626 1 +Phosphoprotein binding 0.2950943193621034 0.111669041254718 0.911085827259054 1.0 0.9879276299724296 17 P62993,Q9Y4P3,P07737 3 +Carbohydrate binding 0.2769923737074954 0.0981067726308149 0.921847509691295 1.0 0.9945609033587473 38 O75503,O15460,P10253 3 +Histone methyltransferase binding 0.3512480389264707 0.0953300719646547 0.9240526574439332 1.0 0.9951930045920648 6 P83916 1 +Oxidoreductase activity acting on nad p h 0.2875562911651855 0.0904164912263124 0.9279562522645888 1.0 0.9972574283657636 21 O95831,O43676 2 +U3 snorna binding 0.305888567578769 0.0809396026254841 0.9354899849275098 1.0 1.0 10 O43818 1 +Gdp binding 0.288827622142294 0.080863524385089 0.935550488257534 1.0 1.0 17 P61020 1 +Retinoic acid receptor binding 0.347826367734198 0.0734664799860571 0.9414349170664696 1.0 1.0 5 P17096 1 +Phosphatidylinositol 3 5 bisphosphate binding 0.4218686250509987 0.0720644355636004 0.9425506289180738 1.0 1.0 3 O60493,Q5MNZ6 2 +Aspartic type peptidase activity 0.4194206446348466 0.0693572204947508 0.9447052799785078 1.0 1.0 3 Q92542,Q8TCT9 2 +Phosphatidylinositol 3 phosphate binding 0.4173806609547115 0.0671542181707185 0.9464589314113978 1.0 1.0 3 O60493,Q5MNZ6 2 +Tap1 binding 0.376835236541598 0.0662671272616936 0.9471651543221644 1.0 1.0 2 Q03519 1 +S adenosylmethionine dependent methyltransferase activity 0.2766059655523168 0.0659030933155918 0.9474549778296304 1.0 1.0 30 P21964,Q96P11,O96028,Q03164,O75648,O60725 6 +Poly pyrimidine tract binding 0.2898764083047225 0.0656989525692246 0.9476175063420528 1.0 1.0 14 P26368,P31943,Q96EP5,Q06787,P07910 5 +Phosphatidylinositol binding 0.2716719252927725 0.058251804619918 0.9535480566248092 1.0 1.0 36 Q9Y2I1,P07737,Q8WTV0 3 +Phosphatidylinositol 4 phosphate binding 0.3658238172920076 0.057292789803555 0.9543119638238532 1.0 1.0 2 O60493 1 +Endoribonuclease activity 0.2824148216356726 0.0519497327044039 0.9585687467781407 1.0 1.0 18 Q9UQ84 1 +Phosphate ion binding 0.336734693877547 0.0455420234625077 0.9636752797498472 1.0 1.0 4 Q8NCH0,P00491,P30520 3 +Ribosomal small subunit binding 0.2876990274086736 0.041402934914479 0.9669746730817794 1.0 1.0 12 Q15056 1 +Oxidoreductase activity acting on ch or ch2 groups 0.3307504078303399 0.0371441673493859 0.9703700558568265 1.0 1.0 2 P31350 1 +Solute proton symporter activity 0.3295269168026095 0.0366404275447141 0.9707717086392916 1.0 1.0 2 O00400 1 +Integrin binding 0.2814718452893495 0.0345121851147444 0.9724687258209586 1.0 1.0 15 P20073,Q03001,P07237,P78536,Q96AC1,Q9Y2I1 6 +Ubiquitin specific protease binding 0.3031434319482877 0.0280851144465349 0.9775942663421752 1.0 1.0 7 Q9BUN8 1 +Disulfide oxidoreductase activity 0.2747988494427601 0.0165152678942023 0.9868233217311946 1.0 1.0 18 O95881,Q6ZRP7,P07237,P78417,Q8IXB1 5 +Potassium ion transmembrane transporter activity 0.3337413300693576 0.0123275176065426 0.990164313147114 1.0 1.0 3 P55011,P05026 2 +Dna binding bending 0.304331989368688 0.0111263557307808 0.9911226357081776 1.0 1.0 6 P26583,Q00059 2 +Acidic amino acid transmembrane transporter activity 0.324357405140752 0.0095647767001185 0.992368528704425 1.0 1.0 3 Q9UJS0,O75746 2 +L aspartate transmembrane transporter activity 0.324357405140752 0.0095647767001185 0.992368528704425 1.0 1.0 3 Q9UJS0,O75746 2 +Cytochrome b5 reductase activity acting on nad p h 0.3133414932680503 0.0069124818985344 0.9944846813388976 1.0 1.0 3 P16435,Q9UHQ9 2 +Oxidoreductase activity acting on nad p h heme protein as acceptor 0.3133414932680503 0.0069124818985344 0.9944846813388976 1.0 1.0 3 P16435,Q9UHQ9 2 +Regulatory rna binding 0.2743626515954536 0.0063697793694518 0.9949176857537956 1.0 1.0 14 P22626,P09651,Q06787,Q9BWF3,Q8IWR0 5 +Prenyltransferase activity 0.2848979591836689 0.0010002228747832 0.9992019377439184 1.0 1.0 4 P37268,P14324,P49356 3 diff --git a/msigdb_gomf/selections.json b/msigdb_gomf/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..be6e8b273fc7c2ec241f93f17d95b5148c227b5f --- /dev/null +++ b/msigdb_gomf/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1 4 alpha oligoglucan phosphorylase activity", "1 acylglycerophosphocholine o acyltransferase activity", "1 alkyl 2 acetylglycerophosphocholine esterase activity", "1 phosphatidylinositol 4 kinase activity", "1 phosphatidylinositol binding", "14 3 3 protein binding", "17 beta hydroxysteroid dehydrogenase nadplus activity", "17 beta hydroxysteroid dehydrogenase nadpplus activity", "2 acylglycerol 3 phosphate o acyltransferase activity", "2 iron 2 sulfur cluster binding", "2 oxoglutarate dependent dioxygenase activity", "3 5 dna helicase activity", "3 5 exodeoxyribonuclease activity", "3 5 exonuclease activity", "3 beta hydroxy delta5 steroid dehydrogenase activity", "3 hydroxyacyl coa dehydratase activity", "3 hydroxyacyl coa dehydrogenase activity", "4 iron 4 sulfur cluster binding", "5 3 dna helicase activity", "5 3 exodeoxyribonuclease activity", "5 3 exonuclease activity", "5 deoxyribose 5 phosphate lyase activity", "5s rrna binding", "7s rna binding", "7sk snrna binding", "Abc type glutathione s conjugate transporter activity", "Abc type transporter activity", "Abc type xenobiotic transporter activity", "Acetyl coa c acetyltransferase activity", "Acetyl coa c acyltransferase activity", "Acetyl coa hydrolase activity", "Acetylcholine receptor binding", "Acetylgalactosaminyltransferase activity", "Acetylglucosaminyltransferase activity", "Acetyltransferase activity", "Acid amino acid ligase activity", "Acid phosphatase activity", "Acid thiol ligase activity", "Acidic amino acid transmembrane transporter activity", "Actin binding", "Actin filament binding", "Actin monomer binding", "Actinin binding", "Active ion transmembrane transporter activity", "Active transmembrane transporter activity", "Acyl carnitine transmembrane transporter activity", "Acyl coa binding", "Acyl coa dehydrogenase activity", "Acyl coa oxidase activity", "Acylglycerol lipase activity", "Acylglycerol o acyltransferase activity", "Acyltransferase activity", "Acyltransferase acyl groups converted into alkyl on transfer", "Adenosine deaminase activity", "Adenyl nucleotide binding", "Adenyl nucleotide exchange factor activity", "Adenylate cyclase binding", "Adenylate kinase activity", "Adenylyltransferase activity", "Adp binding", "Adp ribose diphosphatase activity", "Adp transmembrane transporter activity", "Adrenergic receptor binding", "Alanine transmembrane transporter activity", "Alcohol binding", "Alcohol dehydrogenase activity zinc dependent", "Alcohol dehydrogenase nad p plus activity", "Alcohol dehydrogenase nadpplus activity", "Aldehyde dehydrogenase nad p plus activity", "Aldehyde lyase activity", "Alditol nadpplus 1 oxidoreductase activity", "Aldo keto reductase nadp activity", "Alkali metal ion binding", "Alpha actinin binding", "Alpha catenin binding", "Alpha glucosidase activity", "Alpha tubulin binding", "Amide binding", "Amide transmembrane transporter activity", "Amidine lyase activity", "Amino acid binding", "Amino acid cation symporter activity", "Amino acid sodium symporter activity", "Amino acid transmembrane transporter activity", "Aminoacyl trna editing activity", "Aminoacylase activity", "Aminopeptidase activity", "Ammonium transmembrane transporter activity", "Amp activated protein kinase activity", "Amp binding", "Amyloid beta binding", "Anaphase promoting complex binding", "Androgen receptor binding", "Androstan 3 alpha 17 beta diol dehydrogenase activity", "Anion cation symporter activity", "Anion channel activity", "Anion sodium symporter activity", "Anion transmembrane transporter activity", "Ankyrin binding", "Ankyrin repeat binding", "Annealing activity", "Antigen binding", "Antioxidant activity", "Antiporter activity", "Apolipoprotein a i binding", "Apolipoprotein binding", "Apolipoprotein receptor binding", "Arachidonate coa ligase activity", "Arginine binding", "Armadillo repeat domain binding", "Aromatic amino acid transmembrane transporter activity", "Arp2 3 complex binding", "Arrestin family protein binding", "Aryl hydrocarbon receptor binding", "Arylesterase activity", "Arylsulfatase activity", "Aspartic endopeptidase activity intramembrane cleaving", "Aspartic type endopeptidase inhibitor activity", "Aspartic type peptidase activity", "Atp dependent activity", "Atp dependent activity acting on dna", "Atp dependent activity acting on rna", "Atp dependent chromatin remodeler activity", "Atp dependent dna dna annealing activity", "Atp dependent peptidase activity", "Atp dependent protein binding", "Atp hydrolysis activity", "Atp transmembrane transporter activity", "Atpase activator activity", "Atpase binding", "Atpase coupled cation transmembrane transporter activity", "Atpase coupled inorganic anion transmembrane transporter activity", "Atpase coupled intramembrane lipid transporter activity", "Atpase coupled ion transmembrane transporter activity", "Atpase coupled lipid transmembrane transporter activity", "Atpase coupled transmembrane transporter activity", "Atpase inhibitor activity", "Atpase regulator activity", "Axon guidance receptor activity", "Azole transmembrane transporter activity", "Basal transcription machinery binding", "Beta 1 3 galactosyltransferase activity", "Beta 2 adrenergic receptor binding", "Beta 2 microglobulin binding", "Beta catenin binding", "Beta galactosidase activity", "Beta n acetylhexosaminidase activity", "Beta tubulin binding", "Bh domain binding", "Bh3 domain binding", "Bhlh transcription factor binding", "Bile acid binding", "Bile acid transmembrane transporter activity", "Biotin binding", "Box h aca snorna binding", "Branched chain amino acid transmembrane transporter activity", "Bubble dna binding", "C acetyltransferase activity", "C acyltransferase activity", "C c chemokine binding", "C methyltransferase activity", "C palmitoyltransferase activity", "C x c chemokine binding", "C x3 c chemokine binding", "C2h2 zinc finger domain binding", "C3hc4 type ring finger domain binding", "C4 dicarboxylate transmembrane transporter activity", "Cadherin binding", "Cadherin binding involved in cell cell adhesion", "Calcium cation antiporter activity", "Calcium channel regulator activity", "Calcium dependent cysteine type endopeptidase activity", "Calcium dependent phospholipid binding", "Calcium dependent protein binding", "Calcium dependent protein kinase activity", "Calcium dependent protein serine threonine phosphatase activity", "Calcium independent phospholipase a2 activity", "Calcium ion binding", "Calcium ion transmembrane transporter activity", "Calmodulin binding", "Calmodulin dependent protein kinase activity", "Camp binding", "Camp dependent protein kinase activity", "Camp dependent protein kinase inhibitor activity", "Camp dependent protein kinase regulator activity", "Carbohydrate binding", "Carbohydrate derivative transmembrane transporter activity", "Carbohydrate kinase activity", "Carbohydrate phosphatase activity", "Carbon carbon lyase activity", "Carbon nitrogen ligase activity with glutamine as amido n donor", "Carbon nitrogen lyase activity", "Carbon oxygen lyase activity", "Carbon sulfur lyase activity", "Carbonyl reductase nadph activity", "Carboxy lyase activity", "Carboxylic acid binding", "Carboxylic ester hydrolase activity", "Carboxypeptidase activity", "Cardiolipin binding", "Cargo adaptor activity", "Cargo receptor activity", "Carnitine o acyltransferase activity", "Catalytic activity acting on a glycoprotein", "Catalytic activity acting on a nucleic acid", "Catalytic activity acting on a rrna", "Catalytic activity acting on a trna", "Catalytic activity acting on dna", "Catalytic activity acting on rna", "Cation cation antiporter activity", "Cation channel activity", "Cation chloride symporter activity", "Cation transmembrane transporter activity", "Ccr chemokine receptor binding", "Ccr3 chemokine receptor binding", "Ccr5 chemokine receptor binding", "Cdp alcohol phosphatidyltransferase activity", "Cell adhesion mediator activity", "Cell adhesion molecule binding", "Cell adhesive protein binding involved in bundle of his cell purkinje myocyte communication", "Cell cell adhesion mediator activity", "Cell matrix adhesion mediator activity", "Centromeric dna binding", "Ceramide binding", "Channel inhibitor activity", "Channel regulator activity", "Chaperone binding", "Chemoattractant activity", "Chemokine binding", "Chemokine receptor binding", "Chemorepellent activity", "Chitin binding", "Chloride channel inhibitor activity", "Chloride channel regulator activity", "Cholesterol binding", "Chondroitin sulfate binding", "Chromatin binding", "Chromatin dna binding", "Chromo shadow domain binding", "Cis regulatory region sequence specific dna binding", "Cis trans isomerase activity", "Class i dna apurinic or apyrimidinic site endonuclease activity", "Clathrin binding", "Clathrin heavy chain binding", "Clathrin light chain binding", "Co smad binding", "Coa hydrolase activity", "Cobalamin binding", "Collagen binding", "Collagen binding involved in cell matrix adhesion", "Complement binding", "Complement component c1q complex binding", "Complement component c3b binding", "Copper chaperone activity", "Copper ion binding", "Core promoter sequence specific dna binding", "Coreceptor activity", "Coreceptor activity involved in wnt signaling pathway", "Coreceptor activity involved in wnt signaling pathway planar cell polarity pathway", "Cullin family protein binding", "Cuprous ion binding", "Cxcr chemokine receptor binding", "Cyclic nucleotide binding", "Cyclic nucleotide dependent protein kinase activity", "Cyclic nucleotide phosphodiesterase activity", "Cyclin binding", "Cyclin dependent protein kinase activity", "Cyclin dependent protein serine threonine kinase regulator activity", "Cyclohydrolase activity", "Cyclosporin a binding", "Cysteine type endopeptidase activity", "Cysteine type endopeptidase inhibitor activity", "Cysteine type endopeptidase inhibitor activity involved in apoptotic process", "Cysteine type endopeptidase regulator activity involved in apoptotic process", "Cysteine type exopeptidase activity", "Cysteine type peptidase activity", "Cytidylyltransferase activity", "Cytochrome b5 reductase activity acting on nad p h", "Cytokine activity", "Cytokine binding", "Cytokine receptor activity", "Cytokine receptor binding", "Cytoskeletal anchor activity", "Cytoskeletal motor activity", "Cytoskeletal protein binding", "Cytoskeleton nuclear membrane anchor activity", "D loop dna binding", "D threo aldose 1 dehydrogenase activity", "D1 dopamine receptor binding", "Damaged dna binding", "Deacetylase activity", "Dead h box rna helicase binding", "Deaminase activity", "Death domain binding", "Death receptor activity", "Death receptor binding", "Demethylase activity", "Deoxynucleoside kinase activity", "Deoxyribonuclease activity", "Diacylglycerol binding", "Diacylglycerol kinase activity", "Dicarboxylic acid transmembrane transporter activity", "Dihydropyrimidinase activity", "Dioxygenase activity", "Dipeptidase activity", "Dipeptidyl peptidase activity", "Diphosphotransferase activity", "Disordered domain specific binding", "Disulfide oxidoreductase activity", "Dna apurinic or apyrimidinic site endonuclease activity", "Dna binding bending", "Dna binding transcription activator activity", "Dna binding transcription factor activity", "Dna binding transcription factor binding", "Dna binding transcription repressor activity", "Dna clamp loader activity", "Dna directed dna polymerase activity", "Dna dna annealing activity", "Dna helicase activity", "Dna insertion or deletion binding", "Dna methyltransferase activity", "Dna n glycosylase activity", "Dna polymerase activity", "Dna polymerase binding", "Dna replication origin binding", "Dna secondary structure binding", "Dna topoisomerase activity", "Dna translocase activity", "Dolichyl diphosphooligosaccharide protein glycotransferase activity", "Dolichyl phosphate mannose protein mannosyltransferase activity", "Dopamine receptor binding", "Double stranded methylated dna binding", "Double stranded rna adenosine deaminase activity", "Double stranded rna binding", "Double stranded telomeric dna binding", "Dttp diphosphatase activity", "Dynactin binding", "Dynein complex binding", "Dynein heavy chain binding", "Dynein intermediate chain binding", "Dynein light chain binding", "Dynein light intermediate chain binding", "Dystroglycan binding", "E box binding", "Efflux transmembrane transporter activity", "Electron transfer activity", "Endodeoxyribonuclease activity", "Endodeoxyribonuclease activity producing 5 phosphomonoesters", "Endonuclease activity", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Endopeptidase activator activity", "Endopeptidase activity", "Endopeptidase regulator activity", "Endopolyphosphatase activity", "Endoribonuclease activity", "Endoribonuclease activity producing 5 phosphomonoesters", "Enoyl coa hydratase activity", "Enzyme activator activity", "Enzyme inhibitor activity", "Enzyme regulator activity", "Ephrin receptor activity", "Ephrin receptor binding", "Epidermal growth factor receptor binding", "Epoxide hydrolase activity", "Er retention sequence binding", "Erbb 3 class receptor binding", "Estradiol 17 beta dehydrogenase activity", "Estrogen receptor binding", "Ether hydrolase activity", "Eukaryotic initiation factor 4e binding", "Exodeoxyribonuclease activity", "Exogenous protein binding", "Exonuclease activity", "Exonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Exopeptidase activity", "Exoribonuclease activity", "Exoribonuclease activity producing 5 phosphomonoesters", "Extracellular matrix binding", "Fad binding", "Fatty acid binding", "Fatty acid derivative binding", "Fatty acid ligase activity", "Fatty acid synthase activity", "Fatty acid transmembrane transporter activity", "Ferric iron binding", "Ferrous iron binding", "Fibroblast growth factor binding", "Fibroblast growth factor receptor binding", "Fibronectin binding", "Fk506 binding", "Flap endonuclease activity", "Flavin adenine dinucleotide binding", "Flippase activity", "Floppase activity", "Fmn binding", "Folic acid binding", "Folic acid transmembrane transporter activity", "Four way junction dna binding", "Four way junction helicase activity", "Frizzled binding", "Fructose 2 6 bisphosphate 2 phosphatase activity", "Fructose 6 phosphate binding", "Fructose binding", "G protein activity", "G protein alpha subunit binding", "G protein beta gamma subunit complex binding", "G protein beta subunit binding", "G protein coupled chemoattractant receptor activity", "G protein coupled glutamate receptor binding", "G protein coupled opioid receptor activity", "G protein coupled receptor activity", "G protein coupled receptor binding", "G protein coupled serotonin receptor binding", "G quadruplex dna binding", "G quadruplex rna binding", "G rich strand telomeric dna binding", "Galactosidase activity", "Galactoside binding", "Galactosyltransferase activity", "Gamma aminobutyric acid transmembrane transporter activity", "Gamma catenin binding", "Gamma tubulin binding", "Ganglioside binding", "Gated channel activity", "Gdp binding", "Gdp dissociation inhibitor activity", "General transcription initiation factor activity", "General transcription initiation factor binding", "Glucocorticoid receptor binding", "Glucose binding", "Glucosidase activity", "Glucosyltransferase activity", "Glucuronosyltransferase activity", "Glutamate receptor binding", "Glutathione disulfide oxidoreductase activity", "Glutathione oxidoreductase activity", "Glutathione peroxidase activity", "Glutathione transferase activity", "Glutathione transmembrane transporter activity", "Glyceraldehyde 3 phosphate dehydrogenase nadplus non phosphorylating activity", "Glycerophospholipid flippase activity", "Glycine binding", "Glycolipid binding", "Glycolipid mannosyltransferase activity", "Glycosaminoglycan binding", "Glycosphingolipid binding", "Glycosyltransferase activity", "Gpi anchor binding", "Gpi linked ephrin receptor activity", "Growth factor activity", "Growth factor binding", "Growth factor receptor binding", "Gtp dependent protein binding", "Gtpase activating protein binding", "Gtpase activator activity", "Gtpase activity", "Gtpase binding", "Gtpase inhibitor activity", "Guanyl nucleotide binding", "Guanyl nucleotide exchange factor activity", "Guanylate kinase activity", "Guanylyltransferase activity", "H4 histone acetyltransferase activity", "Heat shock protein binding", "Helicase activity", "Heme transmembrane transporter activity", "Heparin binding", "Hexokinase activity", "Hexosaminidase activity", "Hexosyltransferase activity", "High density lipoprotein particle binding", "Histone acetyltransferase binding", "Histone arginine n methyltransferase activity", "Histone binding", "Histone deacetylase activity h3 k14 specific", "Histone deacetylase binding", "Histone deacetylase regulator activity", "Histone h3 di monomethyl lysine 9 demethylase activity", "Histone h3 methyl lysine 36 demethylase activity", "Histone h3 methyl lysine 4 demethylase activity", "Histone h3 methyl lysine 9 demethylase activity", "Histone kinase activity", "Histone lysine n methyltransferase activity", "Histone methyltransferase activity", "Histone methyltransferase activity h3 k36 specific", "Histone methyltransferase activity h3 k4 specific", "Histone methyltransferase activity h4 k20 specific", "Histone methyltransferase binding", "Histone serine kinase activity", "Histone threonine kinase activity", "Hormone activity", "Hormone binding", "Hormone receptor binding", "Hsp70 protein binding", "Hsp90 protein binding", "Hyaluronic acid binding", "Hyalurononglucosaminidase activity", "Hydro lyase activity", "Hydrolase activity acting on acid anhydrides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amidines", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amidines", "Hydrolase activity acting on ester bonds", "Hydrolase activity acting on ether bonds", "Hydrolase activity acting on glycosyl bonds", "Hydrolase activity hydrolyzing n glycosyl compounds", "Hydrolase activity hydrolyzing o glycosyl compounds", "Hydroxymethyl formyl and related transferase activity", "I smad binding", "Identical protein binding", "Immune receptor activity", "Immunoglobulin binding", "Immunoglobulin receptor binding", "Importin alpha family protein binding", "Inorganic anion transmembrane transporter activity", "Inorganic diphosphatase activity", "Inorganic molecular entity transmembrane transporter activity", "Inorganic phosphate transmembrane transporter activity", "Inositol phosphate phosphatase activity", "Inositol polyphosphate 5 phosphatase activity", "Inositol tetrakisphosphate phosphatase activity", "Inositol trisphosphate phosphatase activity", "Insulin binding", "Insulin like growth factor binding", "Insulin like growth factor ii binding", "Insulin like growth factor receptor binding", "Insulin receptor binding", "Insulin receptor substrate binding", "Integrin binding", "Interleukin 1 binding", "Interleukin 1 receptor binding", "Interleukin 2 receptor binding", "Interleukin 6 receptor binding", "Intermediate filament binding", "Intracellular calcium activated chloride channel activity", "Intraciliary transport particle b binding", "Intramembrane lipid transporter activity", "Intramolecular oxidoreductase activity", "Intramolecular oxidoreductase activity interconverting aldoses and ketoses", "Intramolecular oxidoreductase activity transposing c c bonds", "Intramolecular transferase activity", "Intramolecular transferase activity phosphotransferases", "Intronic transcription regulatory region sequence specific dna binding", "Ion gated channel activity", "Ion transmembrane transporter activity", "Ionotropic glutamate receptor binding", "Iron ion binding", "Iron ion transmembrane transporter activity", "Isocitrate dehydrogenase activity", "Isomerase activity", "Isopeptidase activity", "Isoprenoid binding", "Jun kinase binding", "Jun kinase kinase kinase activity", "K48 linked polyubiquitin modification dependent protein binding", "K63 linked polyubiquitin modification dependent protein binding", "Keratin filament binding", "Kinase activator activity", "Kinase activity", "Kinase binding", "Kinase inhibitor activity", "Kinase regulator activity", "Kinesin binding", "Kinetochore binding", "L alanine transmembrane transporter activity", "L amino acid transmembrane transporter activity", "L ascorbic acid binding", "L aspartate transmembrane transporter activity", "L glutamine transmembrane transporter activity", "L lactate dehydrogenase activity", "L leucine transmembrane transporter activity", "L ornithine transmembrane transporter activity", "L serine transmembrane transporter activity", "Lactate dehydrogenase activity", "Lactate transmembrane transporter activity", "Lamin binding", "Laminin 1 binding", "Laminin binding", "Large ribosomal subunit rrna binding", "Leucine binding", "Leucine zipper domain binding", "Leukotriene c4 synthase activity", "Ligand gated ion channel activity", "Ligase activity", "Ligase activity forming carbon carbon bonds", "Ligase activity forming carbon nitrogen bonds", "Ligase activity forming carbon oxygen bonds", "Ligase activity forming carbon sulfur bonds", "Ligase activity forming phosphoric ester bonds", "Lim domain binding", "Lipase activator activity", "Lipase activity", "Lipase binding", "Lipase inhibitor activity", "Lipid binding", "Lipid kinase activity", "Lipid transfer activity", "Lipid transporter activity", "Lipopolysaccharide binding", "Lipopolysaccharide immune receptor activity", "Lipoprotein particle receptor activity", "Lipoprotein particle receptor binding", "Long chain acyl coa dehydrogenase activity", "Long chain fatty acid binding", "Long chain fatty acid coa ligase activity", "Long chain fatty acid transporter activity", "Long chain fatty acyl coa binding", "Low density lipoprotein particle binding", "Low density lipoprotein particle receptor binding", "Lrr domain binding", "Lyase activity", "Lys48 specific deubiquitinase activity", "Lys63 specific deubiquitinase activity", "Lysine acetylated histone binding", "Lysine n methyltransferase activity", "Lysophosphatidic acid binding", "Lysophosphatidic acid phosphatase activity", "Lysophospholipase activity", "Lysophospholipid acyltransferase activity", "M7g 5 pppn diphosphatase activity", "Macrolide binding", "Macromolecule transmembrane transporter activity", "Magnesium ion binding", "Magnesium ion transmembrane transporter activity", "Malate dehydrogenase activity", "Manganese ion binding", "Manganese ion transmembrane transporter activity", "Mannose binding", "Mannosyltransferase activity", "Map kinase kinase activity", "Map kinase kinase kinase activity", "Map kinase phosphatase activity", "Map kinase scaffold activity", "Map kinase tyrosine serine threonine phosphatase activity", "Mdm2 mdm4 family protein binding", "Medium chain fatty acid coa ligase activity", "Membrane insertase activity", "Metal cluster binding", "Metal dependent deubiquitinase activity", "Metal ion proton antiporter activity", "Metal ion transmembrane transporter activity", "Metalloaminopeptidase activity", "Metallocarboxypeptidase activity", "Metallochaperone activity", "Metallodipeptidase activity", "Metalloendopeptidase activity", "Metalloexopeptidase activity", "Metallopeptidase activity", "Methyl cpg binding", "Methylated histone binding", "Mhc class i protein binding", "Mhc class ib protein binding", "Mhc class ii protein complex binding", "Mhc protein binding", "Mhc protein complex binding", "Microfilament motor activity", "Microtubule binding", "Microtubule minus end binding", "Microtubule motor activity", "Microtubule plus end binding", "Minor groove of adenine thymine rich dna binding", "Minus end directed microtubule motor activity", "Mirna binding", "Misfolded protein binding", "Mismatch repair complex binding", "Mismatched dna binding", "Mitochondrial ribosome binding", "Mitochondrion targeting sequence binding", "Mitogen activated protein kinase binding", "Mitogen activated protein kinase kinase kinase binding", "Mitogen activated protein kinase p38 binding", "Modification dependent protein binding", "Modified amino acid binding", "Modified amino acid transmembrane transporter activity", "Molecular adaptor activity", "Molecular carrier activity", "Molecular function activator activity", "Molecular function inhibitor activity", "Molecular function regulator", "Molecular transducer activity", "Molybdopterin cofactor binding", "Monocarboxylic acid binding", "Monocarboxylic acid transmembrane transporter activity", "Monooxygenase activity", "Monosaccharide binding", "Mrf binding", "Mrna 3 utr au rich region binding", "Mrna 3 utr binding", "Mrna 5 utr binding", "Mrna binding", "Mrna methyltransferase activity", "Muscle alpha actinin binding", "Mutlalpha complex binding", "Myosin binding", "Myosin ii binding", "Myosin v binding", "Myristoyltransferase activity", "N acetylgalactosamine 4 o sulfotransferase activity", "N acetyllactosaminide beta 1 3 n acetylglucosaminyltransferase activity", "N acetyltransferase activity", "N acylsphingosine amidohydrolase activity", "N acyltransferase activity", "N methyltransferase activity", "N6 methyladenosine containing rna binding", "Nad binding", "Nad dependent protein deacetylase activity", "Nad p h oxidase h2o2 forming activity", "Nad p plus protein arginine adp ribosyltransferase activity", "Nad retinol dehydrogenase activity", "Nadh dehydrogenase activity", "Nadh pyrophosphatase activity", "Nadp binding", "Nadp retinol dehydrogenase activity", "Nadph binding", "Nadplus adp ribosyltransferase activity", "Nadplus binding", "Nadplus kinase activity", "Nedd8 specific protease activity", "Nedd8 transferase activity", "Nerve growth factor binding", "Neuroligin family protein binding", "Neurotransmitter receptor regulator activity", "Neurotransmitter transmembrane transporter activity", "Neurotrophin binding", "Neurotrophin receptor activity", "Neurotrophin receptor binding", "Neurotrophin trk receptor binding", "Neutral amino acid transmembrane transporter activity", "Nf kappab binding", "Nitric oxide synthase binding", "Nitric oxide synthase regulator activity", "Nitrite reductase activity", "Non membrane spanning protein tyrosine kinase activity", "Non membrane spanning protein tyrosine phosphatase activity", "Notch binding", "Nuclear export signal receptor activity", "Nuclear import signal receptor activity", "Nuclear localization sequence binding", "Nuclear receptor activity", "Nuclear receptor binding", "Nuclear receptor coactivator activity", "Nuclease activity", "Nucleobase containing compound kinase activity", "Nucleobase containing compound transmembrane transporter activity", "Nucleobase transmembrane transporter activity", "Nucleocytoplasmic carrier activity", "Nucleoside binding", "Nucleoside diphosphatase activity", "Nucleoside diphosphate kinase activity", "Nucleoside kinase activity", "Nucleoside monophosphate kinase activity", "Nucleoside triphosphatase regulator activity", "Nucleoside triphosphate diphosphatase activity", "Nucleosomal dna binding", "Nucleosome binding", "Nucleotidase activity", "Nucleotide diphosphatase activity", "Nucleotide phosphatase activity acting on free nucleotides", "Nucleotide sugar transmembrane transporter activity", "Nucleotide transmembrane transporter activity", "Nucleotidyltransferase activity", "O acetyltransferase activity", "O acyltransferase activity", "O methyltransferase activity", "O palmitoyltransferase activity", "Oleate transmembrane transporter activity", "Oligopeptide binding", "Oligopeptide transmembrane transporter activity", "Oligosaccharide binding", "Oligosaccharyl transferase activity", "Omega peptidase activity", "Opsonin binding", "Organic acid binding", "Organic acid sodium symporter activity", "Organic acid transmembrane transporter activity", "Organic anion transmembrane transporter activity", "Organic cation transmembrane transporter activity", "Organic hydroxy compound transmembrane transporter activity", "Organophosphate ester transmembrane transporter activity", "Oxidative phosphorylation uncoupler activity", "Oxidative rna demethylase activity", "Oxidized dna binding", "Oxidoreductase activity", "Oxidoreductase activity acting on a heme group of donors", "Oxidoreductase activity acting on a sulfur group of donors", "Oxidoreductase activity acting on a sulfur group of donors disulfide as acceptor", "Oxidoreductase activity acting on a sulfur group of donors nad p as acceptor", "Oxidoreductase activity acting on a sulfur group of donors oxygen as acceptor", "Oxidoreductase activity acting on ch oh group of donors", "Oxidoreductase activity acting on ch or ch2 groups", "Oxidoreductase activity acting on diphenols and related substances as donors", "Oxidoreductase activity acting on metal ions", "Oxidoreductase activity acting on metal ions nad or nadp as acceptor", "Oxidoreductase activity acting on nad p h", "Oxidoreductase activity acting on nad p h heme protein as acceptor", "Oxidoreductase activity acting on nad p h oxygen as acceptor", "Oxidoreductase activity acting on nad p h quinone or similar compound as acceptor", "Oxidoreductase activity acting on other nitrogenous compounds as donors", "Oxidoreductase activity acting on other nitrogenous compounds as donors cytochrome as acceptor", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water", "Oxidoreductase activity acting on peroxide as acceptor", "Oxidoreductase activity acting on single donors with incorporation of molecular oxygen", "Oxidoreductase activity acting on the aldehyde or oxo group of donors", "Oxidoreductase activity acting on the aldehyde or oxo group of donors disulfide as acceptor", "Oxidoreductase activity acting on the aldehyde or oxo group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors", "Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors oxygen as acceptor", "Oxidoreductase activity acting on the ch nh group of donors", "Oxidoreductase activity acting on the ch nh group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch nh2 group of donors", "Oxidoreduction driven active transmembrane transporter activity", "Oxo acid lyase activity", "Oxygen binding", "Oxygen sensor activity", "Oxysterol binding", "P type calcium transporter activity", "P type potassium transmembrane transporter activity", "P type transmembrane transporter activity", "P53 binding", "Palmitoyl coa hydrolase activity", "Palmitoyl protein hydrolase activity", "Palmitoyltransferase activity", "Passive transmembrane transporter activity", "Pattern recognition receptor activity", "Pdz domain binding", "Pentosyltransferase activity", "Peptidase activator activity", "Peptidase activator activity involved in apoptotic process", "Peptidase activity", "Peptidase regulator activity", "Peptide alpha n acetyltransferase activity", "Peptide antigen binding", "Peptide binding", "Peptide hormone binding", "Peptide hormone receptor binding", "Peptide lysine n acetyltransferase activity", "Peptide n acetyltransferase activity", "Peptide receptor activity", "Peptide transmembrane transporter activity", "Peptidoglycan binding", "Peptidyl proline 4 dioxygenase activity", "Peptidyl proline dioxygenase activity", "Peroxiredoxin activity", "Peroxisome proliferator activated receptor binding", "Peroxisome targeting sequence binding", "Phosphatase activator activity", "Phosphatase activity", "Phosphatase binding", "Phosphatase inhibitor activity", "Phosphatase regulator activity", "Phosphate ion binding", "Phosphatidic acid binding", "Phosphatidyl phospholipase b activity", "Phosphatidylcholine binding", "Phosphatidylcholine floppase activity", "Phosphatidylcholine transfer activity", "Phosphatidylcholine transporter activity", "Phosphatidylethanolamine binding", "Phosphatidylethanolamine flippase activity", "Phosphatidylglycerol binding", "Phosphatidylinositol 3 4 5 trisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate 5 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 5 bisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate phosphatase activity", "Phosphatidylinositol 3 kinase binding", "Phosphatidylinositol 3 kinase regulator activity", "Phosphatidylinositol 3 kinase regulatory subunit binding", "Phosphatidylinositol 3 phosphate binding", "Phosphatidylinositol 4 5 bisphosphate 5 phosphatase activity", "Phosphatidylinositol 4 5 bisphosphate binding", "Phosphatidylinositol 4 5 bisphosphate phosphatase activity", "Phosphatidylinositol 4 phosphate binding", "Phosphatidylinositol 5 phosphate binding", "Phosphatidylinositol binding", "Phosphatidylinositol bisphosphate binding", "Phosphatidylinositol bisphosphate phosphatase activity", "Phosphatidylinositol kinase activity", "Phosphatidylinositol monophosphate phosphatase activity", "Phosphatidylinositol phosphate 4 phosphatase activity", "Phosphatidylinositol phosphate 5 phosphatase activity", "Phosphatidylinositol phosphate binding", "Phosphatidylinositol phosphate phosphatase activity", "Phosphatidylinositol transfer activity", "Phosphatidylinositol trisphosphate phosphatase activity", "Phosphatidylserine binding", "Phosphodiesterase i activity", "Phosphofructokinase activity", "Phospholipase a2 activity", "Phospholipase a2 inhibitor activity", "Phospholipase activity", "Phospholipase binding", "Phospholipase c activity", "Phospholipase d activity", "Phospholipase inhibitor activity", "Phospholipid binding", "Phospholipid transfer activity", "Phospholipid transporter activity", "Phosphoprotein binding", "Phosphoprotein phosphatase activity", "Phosphoric diester hydrolase activity", "Phosphoric ester hydrolase activity", "Phosphorus oxygen lyase activity", "Phosphoserine residue binding", "Phosphotransferase activity for other substituted phosphate groups", "Phosphotransferase activity nitrogenous group as acceptor", "Phosphotransferase activity phosphate group as acceptor", "Phosphotyrosine residue binding", "Plus end directed microtubule motor activity", "Poly a binding", "Poly a specific ribonuclease activity", "Poly g binding", "Poly purine tract binding", "Poly pyrimidine tract binding", "Polynucleotide adenylyltransferase activity", "Polypeptide n acetylgalactosaminyltransferase activity", "Polysaccharide binding", "Polysome binding", "Polyubiquitin modification dependent protein binding", "Porin activity", "Potassium channel inhibitor activity", "Potassium channel regulator activity", "Potassium chloride symporter activity", "Potassium ion binding", "Potassium ion transmembrane transporter activity", "Pre mirna binding", "Pre mrna 3 splice site binding", "Pre mrna 5 splice site binding", "Pre mrna binding", "Pre mrna intronic binding", "Prenyltransferase activity", "Primary active transmembrane transporter activity", "Primary mirna binding", "Procollagen proline 4 dioxygenase activity", "Procollagen proline dioxygenase activity", "Profilin binding", "Proline rich region binding", "Promoter specific chromatin binding", "Protease binding", "Proteasome activating activity", "Proteasome binding", "Protein adp ribosylase activity", "Protein antigen binding", "Protein arginine n methyltransferase activity", "Protein arginine omega n asymmetric methyltransferase activity", "Protein arginine omega n monomethyltransferase activity", "Protein binding involved in heterotypic cell cell adhesion", "Protein c terminus binding", "Protein carboxyl o methyltransferase activity", "Protein carrier chaperone", "Protein containing complex binding", "Protein cysteine s stearoyltransferase activity", "Protein deacetylase activity", "Protein demethylase activity", "Protein dimerization activity", "Protein disaggregase activity", "Protein disulfide isomerase activity", "Protein disulfide reductase nad p activity", "Protein domain specific binding", "Protein folding chaperone", "Protein geranylgeranyltransferase activity", "Protein heterodimerization activity", "Protein homodimerization activity", "Protein kinase a binding", "Protein kinase a catalytic subunit binding", "Protein kinase a regulatory subunit binding", "Protein kinase activity", "Protein kinase b binding", "Protein kinase c activity", "Protein kinase c binding", "Protein lipid complex binding", "Protein macromolecule adaptor activity", "Protein membrane adaptor activity", "Protein methyltransferase activity", "Protein n terminus binding", "Protein phosphatase 1 binding", "Protein phosphatase 2a binding", "Protein phosphatase 2b binding", "Protein phosphatase activator activity", "Protein phosphatase binding", "Protein phosphatase regulator activity", "Protein phosphorylated amino acid binding", "Protein prenyltransferase activity", "Protein self association", "Protein serine kinase activity", "Protein serine threonine kinase activator activity", "Protein serine threonine kinase activity", "Protein serine threonine kinase inhibitor activity", "Protein serine threonine phosphatase activity", "Protein serine threonine tyrosine kinase activity", "Protein tag", "Protein transmembrane transporter activity", "Protein transporter activity", "Protein tyrosine kinase activator activity", "Protein tyrosine kinase activity", "Protein tyrosine kinase binding", "Protein tyrosine kinase inhibitor activity", "Protein tyrosine phosphatase activity", "Protein tyrosine serine threonine phosphatase activity", "Protein tyrosine threonine phosphatase activity", "Proteoglycan binding", "Proton channel activity", "Proton transmembrane transporter activity", "Proton transporting atp synthase activity rotational mechanism", "Pseudouridine synthase activity", "Purine nucleotide transmembrane transporter activity", "Pyrimidine nucleotide binding", "Pyrimidine nucleotide sugar transmembrane transporter activity", "Pyrophosphate hydrolysis driven proton transmembrane transporter activity", "Pyruvate dehydrogenase acetyl transferring kinase activity", "Pyruvate dehydrogenase activity", "Quaternary ammonium group binding", "Quaternary ammonium group transmembrane transporter activity", "Quinone binding", "R smad binding", "Racemase and epimerase activity", "Racemase and epimerase activity acting on carbohydrates and derivatives", "Rage receptor binding", "Rdna binding", "Receptor antagonist activity", "Receptor tyrosine kinase binding", "Regulatory rna binding", "Retinal binding", "Retinal dehydrogenase activity", "Retinoic acid binding", "Retinoic acid receptor binding", "Retinoid x receptor binding", "Retromer complex binding", "Ribonuclease activity", "Ribonuclease p activity", "Ribonuclease p rna binding", "Ribonucleoprotein complex binding", "Ribonucleotide binding", "Ribose phosphate diphosphokinase activity", "Ribosomal large subunit binding", "Ribosomal protein s6 kinase activity", "Ribosomal small subunit binding", "Ribosome binding", "Rna 2 o methyltransferase activity", "Rna 7 methylguanosine cap binding", "Rna adenylyltransferase activity", "Rna binding", "Rna binding involved in posttranscriptional gene silencing", "Rna cap binding", "Rna directed dna polymerase activity", "Rna dna hybrid ribonuclease activity", "Rna methyltransferase activity", "Rna polymerase activity", "Rna polymerase binding", "Rna polymerase core enzyme binding", "Rna polymerase i general transcription initiation factor activity", "Rna polymerase i transcription regulatory region sequence specific dna binding", "Rna polymerase ii activity", "Rna polymerase ii c terminal domain binding", "Rna polymerase ii c terminal domain phosphoserine binding", "Rna polymerase ii core promoter sequence specific dna binding", "Rna polymerase ii ctd heptapeptide repeat kinase activity", "Rna polymerase ii ctd heptapeptide repeat phosphatase activity", "Rna polymerase ii general transcription initiation factor activity", "Rna polymerase ii general transcription initiation factor binding", "Rna polymerase ii intronic transcription regulatory region sequence specific dna binding", "Rna polymerase ii specific dna binding transcription factor binding", "Rna polymerase iii transcription regulatory region sequence specific dna binding", "Rna stem loop binding", "Rna strand annealing activity", "Roundabout binding", "Rrna adenine methyltransferase activity", "Rrna binding", "Rrna cytosine methyltransferase activity", "S acyltransferase activity", "S adenosyl l methionine binding", "S adenosylmethionine dependent methyltransferase activity", "S methyltransferase activity", "S100 protein binding", "Salt transmembrane transporter activity", "Scaffold protein binding", "Scavenger receptor activity", "Secondary active transmembrane transporter activity", "Sequence specific dna binding", "Sequence specific mrna binding", "Sequence specific single stranded dna binding", "Serine hydrolase activity", "Serine transmembrane transporter activity", "Serine type carboxypeptidase activity", "Serine type endopeptidase inhibitor activity", "Serine type exopeptidase activity", "Sh2 domain binding", "Sh3 domain binding", "Signal recognition particle binding", "Signal sequence binding", "Signaling adaptor activity", "Signaling receptor binding", "Signaling receptor complex adaptor activity", "Signaling receptor inhibitor activity", "Signaling receptor regulator activity", "Single stranded dna 3 5 exodeoxyribonuclease activity", "Single stranded dna binding", "Single stranded dna endodeoxyribonuclease activity", "Single stranded dna exodeoxyribonuclease activity", "Single stranded dna helicase activity", "Single stranded rna binding", "Single stranded telomeric dna binding", "Sirna binding", "Smad binding", "Small molecule sensor activity", "Small protein activating enzyme binding", "Small ribosomal subunit rrna binding", "Snap receptor activity", "Snare binding", "Snorna binding", "Snrna binding", "Snrnp binding", "Sodium channel inhibitor activity", "Sodium channel regulator activity", "Sodium chloride symporter activity", "Sodium ion binding", "Sodium ion transmembrane transporter activity", "Solute anion antiporter activity", "Solute cation antiporter activity", "Solute cation symporter activity", "Solute proton antiporter activity", "Solute proton symporter activity", "Solute sodium symporter activity", "Spectrin binding", "Sphingolipid binding", "Sphingolipid transfer activity", "Sphingolipid transporter activity", "Sphingomyelin phosphodiesterase activity", "Sphingosine n acyltransferase activity", "Steroid binding", "Steroid dehydrogenase activity", "Steroid dehydrogenase activity acting on the ch oh group of donors nad or nadp as acceptor", "Steroid hormone binding", "Steroid hormone receptor activity", "Sterol binding", "Sterol esterase activity", "Sterol transfer activity", "Sterol transporter activity", "Structural constituent of cytoskeleton", "Structural constituent of eye lens", "Structural constituent of muscle", "Structural constituent of nuclear pore", "Structural constituent of postsynapse", "Structural constituent of postsynaptic actin cytoskeleton", "Structural constituent of presynaptic active zone", "Structural constituent of ribosome", "Structural constituent of synapse", "Structural molecule activity", "Structural molecule activity conferring elasticity", "Succinate transmembrane transporter activity", "Sulfate binding", "Sulfate transmembrane transporter activity", "Sulfatide binding", "Sulfotransferase activity", "Sulfur compound binding", "Sulfur compound transmembrane transporter activity", "Sulfuric ester hydrolase activity", "Sulfurtransferase activity", "Sumo binding", "Sumo ligase activity", "Sumo specific protease activity", "Sumo transferase activity", "Supercoiled dna binding", "Superoxide dismutase activity", "Symporter activity", "Syntaxin 1 binding", "Syntaxin binding", "T cell receptor binding", "Tap binding", "Tap1 binding", "Tat protein binding", "Tau protein binding", "Tau protein kinase activity", "Tbp class protein binding", "Telomerase activity", "Telomerase rna binding", "Telomeric dna binding", "Testosterone dehydrogenase nad p activity", "Testosterone dehydrogenase nadplus activity", "Tetrapyrrole binding", "Tfiib class transcription factor binding", "Tfiid class transcription factor complex binding", "Thiamine pyrophosphate binding", "Thioesterase binding", "Thiol oxidase activity", "Thiolester hydrolase activity", "Thioredoxin disulfide reductase activity", "Threonine type endopeptidase activity", "Threonine type peptidase activity", "Thyroid hormone receptor binding", "Titin binding", "Toll like receptor binding", "Toxic substance binding", "Tpr domain binding", "Transcription coactivator activity", "Transcription coactivator binding", "Transcription coregulator activity", "Transcription coregulator binding", "Transcription corepressor activity", "Transcription corepressor binding", "Transcription elongation regulator activity", "Transcription factor binding", "Transcription regulator activity", "Transcription regulator inhibitor activity", "Transferase activity transferring alkyl or aryl other than methyl groups", "Transferase activity transferring nitrogenous groups", "Transferase activity transferring one carbon groups", "Transferase activity transferring phosphorus containing groups", "Transferase activity transferring sulphur containing groups", "Transferrin receptor binding", "Transforming growth factor beta receptor binding", "Transition metal ion binding", "Transition metal ion transmembrane transporter activity", "Transketolase or transaldolase activity", "Translation activator activity", "Translation elongation factor activity", "Translation factor activity rna binding", "Translation initiation factor activity", "Translation initiation factor binding", "Translation regulator activity", "Translation regulator activity nucleic acid binding", "Translation repressor activity", "Translation repressor activity mrna regulatory element binding", "Translation termination factor activity", "Transmembrane receptor protein kinase activity", "Transmembrane receptor protein tyrosine kinase activity", "Transmembrane transporter binding", "Transporter activity", "Tripeptide transmembrane transporter activity", "Trna binding", "Trna cytosine methyltransferase activity", "Trna guanine methyltransferase activity", "Trna methyltransferase activity", "Trna specific adenosine deaminase activity", "Trna specific ribonuclease activity", "Tropomyosin binding", "Tubulin binding", "Tumor necrosis factor activated receptor activity", "Tumor necrosis factor receptor binding", "Tumor necrosis factor receptor superfamily binding", "Type 1 fibroblast growth factor receptor binding", "Type i transforming growth factor beta receptor binding", "U1 snrna binding", "U2 snrna binding", "U3 snorna binding", "U4 snrna binding", "U6 snrna binding", "Ubiquinol cytochrome c reductase activity", "Ubiquinone binding", "Ubiquitin binding", "Ubiquitin conjugating enzyme binding", "Ubiquitin ligase substrate adaptor activity", "Ubiquitin like modifier activating enzyme activity", "Ubiquitin like protein binding", "Ubiquitin like protein conjugating enzyme activity", "Ubiquitin like protein conjugating enzyme binding", "Ubiquitin like protein ligase activity", "Ubiquitin like protein ligase binding", "Ubiquitin like protein specific isopeptidase activity", "Ubiquitin like protein specific protease activity", "Ubiquitin like protein transferase activity", "Ubiquitin protein transferase activator activity", "Ubiquitin protein transferase inhibitor activity", "Ubiquitin protein transferase regulator activity", "Ubiquitin specific protease binding", "Ubiquitin ubiquitin ligase activity", "Ubiquitination like modification dependent protein binding", "Udp galactose beta n acetylglucosamine beta 1 3 galactosyltransferase activity", "Udp glucosyltransferase activity", "Udp glycosyltransferase activity", "Udp xylosyltransferase activity", "Unfolded protein binding", "Unmethylated cpg binding", "Uridylyltransferase activity", "Vascular endothelial growth factor receptor 2 binding", "Vascular endothelial growth factor receptor binding", "Very long chain fatty acid coa ligase activity", "Vinculin binding", "Virion binding", "Vitamin b6 binding", "Vitamin binding", "Vitamin d binding", "Vitamin d receptor binding", "Vitamin transmembrane transporter activity", "Voltage gated anion channel activity", "Voltage gated calcium channel activity", "Voltage gated calcium channel activity involved in regulation of cytosolic calcium levels", "Voltage gated cation channel activity", "Voltage gated channel activity", "Voltage gated chloride channel activity", "Volume sensitive anion channel activity", "Water channel activity", "Water transmembrane transporter activity", "Wd40 repeat domain binding", "Wide pore channel activity", "Ww domain binding", "Xenobiotic transmembrane transporter activity", "Y form dna binding", "Zinc ion binding"], "available_proteins": ["AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABHD10", "ABHD12", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR6", "ADAM17", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC5", "ANAPC7", "ANK3", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3M1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOL2", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARMT1", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG4B", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATPIF1", "ATXN2L", "AUP1", "B4GAT1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAT2", "BCCIP", "BCLAF1", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPTF", "BRCA1", "BRD2", "BRIX1", "BRMS1L", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BYSL", "BZW1", "C1QBP", "C1orf123", "C1orf35", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC47", "CCDC6", "CCDC86", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD3EAP", "CDC23", "CDC27", "CDC34", "CDC37", "CDC42", "CDC5L", "CDC73", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKAL1", "CEBPZ", "CECR2", "CELF1", "CENPB", "CERS2", "CFAP20", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD4", "CHERP", "CHID1", "CHKA", "CHMP3", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT6", "CNOT7", "CNOT9", "CNP", "COIL", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS4", "COPS5", "COPS6", "CORO1B", "CORO1C", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX7A2", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DGCR8", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIAPH1", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPF2", "DPH2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI2", "EDC3", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOB", "ELP1", "ELP2", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "ENSA", "ENY2", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERH", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOSC1", "EXOSC10", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAHD1", "FAM208A", "FAM49B", "FAM98A", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FDFT1", "FDPS", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FOXK1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GIGYF2", "GLA", "GLB1", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLGB1", "GOT1", "GOT2", "GPAA1", "GPATCH4", "GPD2", "GPI", "GPR107", "GPRASP2", "GPS1", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C4", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIC2", "HIF1AN", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOXA10", "HP1BP3", "HPF1", "HPRT1", "HPS6", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMPDH2", "INA", "INCENP", "INF2", "INTS11", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRGQ", "IRS4", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC2", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMP1", "LAMTOR1", "LAMTOR2", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDAH", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3BP", "LGMN", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LUC7L", "LUC7L3", "LYAR", "LYPLA1", "MACF1", "MAGT1", "MAK16", "MAP1B", "MAP1S", "MAP2K1", "MAP4", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARCKSL1", "MARK2", "MARS", "MAT2A", "MATR3", "MAU2", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED16", "METAP2", "METTL13", "MFN1", "MFN2", "MGEA5", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMGT1", "MMS19", "MOGS", "MORF4L1", "MOV10", "MPHOSPH10", "MPI", "MPP2", "MPRIP", "MPST", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL39", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL58", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTPN", "MTR", "MYBBP1A", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDUFA10", "NDUFA4", "NDUFA5", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFAF7", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFCD", "NEMF", "NENF", "NES", "NEU1", "NHP2", "NIFK", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NPTN", "NRBP1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP35", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "OAT", "OCLN", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OSBP", "OSBPL11", "OSBPL6", "OSBPL9", "OTUB1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCM1", "PCMT1", "PCNA", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIN4", "PIR", "PISD", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLAA", "PLBD2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1R10", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PPP6R3", "PPT1", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTRH2", "PTRHD1", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RABGGTA", "RABL6", "RAC1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAD51AP1", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM34", "RBM39", "RBM4", "RBM45", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "RECQL5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIOK2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF114", "RNF20", "RNF40", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP1B", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF8", "SCAMP1", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC3A2", "SLC6A15", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMYD3", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX2", "SNX3", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPCS2", "SPCS3", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SQLE", "SQSTM1", "SRCAP", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "SSU72", "STAG2", "STARD3", "STAT3", "STAU1", "STAU2", "STEAP3", "STIP1", "STMN1", "STOML2", "STRAP", "STRBP", "STRN4", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYNCRIP", "SYNE2", "TACO1", "TAF15", "TAGLN2", "TALDO1", "TAMM41", "TAP1", "TAP2", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF25", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TFAM", "TFG", "TFRC", "THG1L", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TK1", "TKT", "TLN1", "TMCO1", "TMED10", "TMED9", "TMEM109", "TMEM192", "TMEM201", "TMEM43", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TNKS1BP1", "TNPO1", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOX4", "TP53", "TP53BP1", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRMT6", "TRMU", "TRNT1", "TROVE2", "TSC2", "TSFM", "TSG101", "TSN", "TSR1", "TSTA3", "TTC1", "TTC21B", "TTC26", "TTC4", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBL5", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UCHL5", "UFC1", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF3B", "UQCR10", "UQCRC1", "UQCRC2", "UROD", "USO1", "USP10", "USP14", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VPS16", "VPS18", "VPS33B", "VPS35", "VPS4B", "VRK1", "VRK3", "WARS", "WBP11", "WDHD1", "WDR1", "WDR12", "WDR3", "WDR33", "WDR36", "WDR4", "WDR43", "WDR45B", "WDR46", "WDR5", "WDR6", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIZ", "WRAP53", "XPNPEP1", "XPO1", "XPO4", "XPO5", "XPO7", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YEATS2", "YEATS4", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBTB10", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZDHHC20", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZNF148", "ZNF281", "ZNF318", "ZNF326", "ZNF638", "ZRANB2", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ABCC4", "ABCD3", "ABHD10", "ACADS", "ACBD3", "ACOT7", "ACOX1", "ACP2", "ADAM17", "ADSS", "AGPS", "AHNAK", "AIFM1", "AK2", "AK6", "AKAP8L", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ANXA1", "ANXA11", "ANXA2", "ANXA7", "APMAP", "APOL2", "APP", "ARF4", "ARL1", "ASAH1", "ASNA1", "ATP13A1", "ATP1B1", "ATP2A2", "ATP5F1", "ATP5H", "ATP5J2", "ATP5L", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATPIF1", "AUP1", "B4GAT1", "BABAM2", "BAG6", "BAIAP2", "BAZ2A", "C1QBP", "CACYBP", "CALR", "CALU", "CAPN2", "CBX1", "CBX3", "CERS2", "CHST14", "CIRBP", "CLN5", "CLPP", "CNOT6", "CNOT7", "CNOT9", "COMT", "COPS4", "COPS5", "COX2", "COX5A", "COX7A2", "CPVL", "CRTAP", "CTSA", "CUTA", "CYB5B", "CYB5D2", "CYB5R1", "CYP51A1", "DAZAP1", "DCPS", "DCTPP1", "DERL1", "DHCR24", "DHCR7", "DHFR", "DHPS", "DIS3", "DNAJA1", "DNAJA2", "DNAJC10", "DNAJC2", "DNAJC3", "DNAJC8", "DNAJC9", "DNM2", "DPH2", "DSP", "DST", "DTYMK", "DUSP9", "ECE1", "EIF4B", "EIF4H", "EIF5", "EPHA7", "ERAP1", "ERP29", "ESYT1", "ETFA", "ETFDH", "EXO1", "EXOSC1", "EXOSC3", "EXOSC7", "EZR", "FAF2", "FAM49B", "FDFT1", "FDPS", "FERMT2", "FKBP10", "FKBP14", "FKBP3", "FKBP7", "FMR1", "FNTB", "FUCA2", "GAA", "GALNT1", "GBA", "GET4", "GGH", "GLA", "GLB1", "GLUD1", "GM2A", "GNA13", "GNAI2", "GNAI3", "GNS", "GRB2", "GSTO1", "GUSB", "HADH", "HADHA", "HLA-C", "HM13", "HMGA1", "HMGB1", "HMGB2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPH1", "HSD17B12", "HSDL1", "HSPA13", "HSPA1B", "HSPB1", "HTRA2", "ICMT", "IDH1", "IDH2", "IFT27", "IPO11", "IRS4", "ITCH", "JUP", "KDELR1", "KDM1B", "KDSR", "KMT2A", "LAMP1", "LANCL1", "LBR", "LIMA1", "LNPEP", "MARC1", "MFN1", "MFN2", "MGEA5", "MGST3", "MIPEP", "MMAB", "MMGT1", "MPP2", "MRPS27", "MTAP", "MTMR6", "MYL6", "NAA40", "NADK2", "NAMPT", "NCLN", "NCSTN", "NDUFB3", "NDUFS2", "NENF", "NEU1", "NISCH", "NME1", "NNT", "NPC1", "NPC2", "NPEPPS", "NPTN", "NRDC", "NSD2", "NSFL1C", "NSUN5", "NT5C3B", "NTMT1", "NUCB1", "NUCB2", "NUP62", "OLA1", "OPA1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PCYOX1", "PDCD5", "PDCD6", "PDCL3", "PEBP1", "PFDN5", "PFN1", "PGRMC2", "PIR", "PITPNA", "PITRM1", "PLAA", "PLD3", "PNP", "PON2", "POR", "PPID", "PPP2R5D", "PPT1", "PRCP", "PRKACA", "PRKAR1A", "PSMA6", "PSMB1", 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0.3367867805298957 1.0 0.4879422487809789 0.1503379894830936 0.006170616419179 0.0153263743673802 +Abnormal neuron morphology 8 27 2.3470991051348618 0.018920221515845 6.186893203883495 28.24514563106796 0.6484714329574719 0.4735595458743487 3.2896606279139218 2.2567268866496706 0.9337112301481814 0.3347227917865519 1.0 1.0 0.1411421437582085 0.0002170138050277 0.0014152418620824 +Wide anterior fontanel 6 16 2.344240733875612 0.019065860922057 6.883495145631068 22.87135922330097 0.5984883047357004 0.51093763506043 3.004207311482479 3.16541613655465 0.8343647618961921 0.3244934138131808 1.0 0.2516504230112798 0.4440833899821513 0.0031264397563519 0.024234085217851 +Fatigable weakness of swallowing muscles 4 13 2.330011129620235 0.01980556289246 3.604368932038835 13.28640776699029 0.7350730209032469 0.4315977104446384 2.070664341544873 1.3796403459639466 0.8910590288568366 0.3148309196851129 1.0 1.0 0.2540772386550496 0.0006827439557333 0.0026462677024259 +Fatigable weakness of respiratory muscles 4 14 2.32924565826018 0.0198460553745523 3.781553398058252 14.49514563106796 0.6722462704336608 0.4649039538010518 2.229730602074667 1.5192856420985286 0.8723926977398212 0.3188845594433921 1.0 1.0 0.3102657432506607 0.002055769463525 0.0088977066355322 +Abnormality of the ribs 17 46 2.3199272996554665 0.0203448104814301 15.46359223300971 63.26456310679612 0.6596881680500318 0.4822792711086646 5.162987649103379 7.327989071924885 1.0464354559452582 0.3722680363619953 0.0396173017666411 0.07440901727418 0.01433463197651 0.0260669626113182 0.0043508167056441 +Proximal tubulopathy 9 19 2.3159043859886763 0.0205634898049626 7.269417475728155 23.25 0.6812729764745832 0.3939568357360496 3.269858916003623 2.8782959157530654 1.2124757185225692 0.3205652179980567 1.0 0.187449079081247 0.0651781855152293 0.0005352167677164 0.0001658127509287 +Agitation 11 31 2.309984080273628 0.0208890355060573 7.783980582524272 33.74514563106796 0.4932072887206141 0.539498681697567 3.185134719927712 2.715579061450019 0.8594629025665722 0.3326769094795885 1.0 1.0 0.1751944604904992 0.0005596761316752 0.0003180118516883 +Increased bone mineral density 9 23 2.298154849066153 0.021552977434208 6.242718446601942 24.75 1.1480702818250033 0.3148175930983396 2.4533156459354677 2.2345749579547443 1.0849696139569316 0.312718333498069 1.0 0.3075216202298709 0.0375044006736284 8.331817056305445e-05 0.0002478460802896 +Retinopathy 8 22 2.2948864641253497 0.0217396317311726 7.716019417475728 27.516990291262136 0.7648928031827923 0.4912060355555205 3.3040774573673595 3.4588008851352714 0.8590527654816497 0.3424638793573584 1.0 0.3241278561278478 0.185657500723835 0.0007216204137279 0.0016206046884794 +Micromelia 6 19 2.293453115267274 0.0218219316683623 5.094660194174757 22.143203883495147 0.8629445430209934 0.441515711810184 2.300964472974588 2.4557002100293746 0.9703688762337884 0.333324080713348 0.0138792179413717 0.0003610843580779 0.0006115018545631 0.0015612560180347 0.0200631156523385 +Neurodegeneration 6 26 2.2720992387936736 0.0230805170862242 6.381067961165049 28.4126213592233 0.4868261799791588 0.5776802355314765 3.0342592105069612 2.3821007132544736 0.7766560160165384 0.3229356835194168 1.0 1.0 0.0251363642152908 0.000923573561466 0.0122020548708259 +Hypoglycemic coma 5 9 2.270118436086904 0.0232003980282329 2.941747572815534 8.725728155339805 0.2432727608444667 0.4894449727236479 1.7957622321824631 0.5745561426457271 0.957288443769672 0.2970452414924103 1.0 0.0652597674910206 0.0078714328443906 0.0002735626391213 2.5790420180080805e-05 +Paraparesis 6 24 2.267655228145227 0.0233502286979998 6.871359223300971 28.233009708737864 0.6400248426097842 0.4864726145707422 2.711080302193058 2.7797949337481977 0.9964067729408944 0.345088346487725 1.0 1.0 0.1151189883762866 0.0005673930602398 0.0076148036114981 +Low frustration tolerance 3 7 2.261248297421463 0.0237438858757426 2.2402912621359223 8.861650485436893 0.6170800437496735 0.4474642212406593 1.8402268519458895 1.0394103977385205 0.9109780988264436 0.3087684537640934 0.0031361768388165 0.0742352733278267 0.144637307685789 0.0004788146962384 0.0060423314672148 +Fatigable weakness of bulbar muscles 4 14 2.2547879252919545 0.0241466435512573 4.063106796116505 15.25242718446602 0.7188062683419271 0.4547422847838221 2.248170358195387 1.4859761696395852 0.8778510505210118 0.3261836450387849 1.0 1.0 0.3367676981326228 0.0032221742646108 0.0143931802338971 +Respiratory distress 11 42 2.2526973747686325 0.0242782365929061 12.805825242718448 52.09466019417476 0.6386570898760532 0.4437575130669694 5.288397728288474 5.051988998968333 1.24726945526474 0.3693239953771813 0.02611336682764 0.1354750356227081 0.0412611149036703 9.270672493242102e-05 0.0050036983612911 +Abnormality of corneal stroma 4 10 2.2490752719554683 0.0245077075043025 4.733009708737864 13.131067961165048 0.6716440045814968 0.2233795964932449 1.7589100966397004 2.506749302052849 1.61853564814875 0.2527544669587041 1.0 0.2480154974279715 0.0195000915431133 0.0136344588869589 0.0629042462862528 +Bulbar signs 4 9 2.2369814683004576 0.0252875512588226 4.888349514563107 12.016990291262136 1.527818207801298 0.1656113111527082 2.218011046873564 1.4803576942139227 1.2783367300196684 0.2344360472575242 1.0 1.0 1.0 0.0069928111010265 0.0172708661402063 +Abnormal rib cage morphology 17 52 2.236417491464495 0.0253244364297511 17.694174757281555 75.7135922330097 0.5488633555797945 0.5379800174608891 5.594611229067785 9.71314341791714 0.9782995531616954 0.3690468558866111 0.0490139609894677 0.1213579811006091 0.0363775905610641 0.0860893707958554 0.0358303458048183 +Hypoketotic hypoglycemia 4 7 2.235355828774311 0.0253939975497496 2.3470873786407767 7.560679611650485 1.365087782487965 0.212332843161917 1.4324316558480732 0.6923349575659244 0.8002406012991511 0.2265642620801705 1.0 0.0516364610584135 0.0048484802924912 9.549361773523036e-05 9.117164830587188e-05 +Dyspnea 17 82 2.204531978136187 0.0274869535813773 21.026699029126213 99.08495145631068 0.338494152708191 0.5916975591038598 7.650862365043173 8.679854297666031 0.9096277682010132 0.3494553445560299 0.0505437226338604 0.3582794844835456 0.0413338875524734 1.7620509975988434e-05 0.0017138049207078 +Abnormal circulating fatty acid concentration 8 17 2.201159791508939 0.0277247136714486 5.851941747572815 19.300970873786408 0.8709428538401427 0.3748768442629192 3.3070858195646933 2.246183176686473 0.9913820617853404 0.2893310559059322 1.0 0.1835089509173778 0.0625314301217693 0.0004698927732866 0.0001368435057556 +Vascular neoplasm 4 27 2.199465603770258 0.0278448322990483 7.924757281553398 36.20388349514563 0.3258157858828113 0.6059539058091996 3.6279214795080814 4.218795722199633 0.7682389896955812 0.3040770756760007 0.0226256880583409 0.0180869455940733 0.005348854267881 0.0615701180840998 0.1942687219099621 +Abnormal periventricular white matter morphology 6 31 2.1975960560932246 0.0279779045335335 8.133495145631068 39.449029126213595 0.0967860419836868 0.5875341906013771 3.8540288360874926 4.20757800279889 0.8600230585764621 0.3110636695940621 0.0187431780938963 0.3716405295483306 0.0664874170634557 0.0084325378638661 0.0900813011244875 +Periventricular white matter hyperintensities 2 6 2.197172161182038 0.028008153009112 2.978155339805826 8.604368932038835 0.7206271937008832 0.2495118997135797 1.313488091366194 1.3113693798075805 1.4898193087366574 0.2872267653893681 1.0 1.0 0.0090253131212995 0.0050923434600555 0.0326009204464092 +Dementia 13 50 2.1928562107117218 0.0283177405266767 17.021844660194176 58.19174757281554 0.9978727756866732 0.3214313161707923 5.814027938449679 5.568168011495494 1.793982160512653 0.3770196158976925 1.0 1.0 0.148051344240397 0.0001147533965622 0.000295286471728 +Biliary cirrhosis 1 5 2.188204587834814 0.0286547030779265 1.9733009708737863 6.650485436893204 1.1218722294682368 0.279893930524248 1.1603338056285764 0.598683634692072 0.8535321112514973 0.2502325498718601 1.0 0.0014481500629001 0.0057815105752346 0.032628233248221 0.1106683855513067 +Paralysis 9 41 2.1864399915577324 0.0287834304719658 11.973300970873789 49.77427184466019 0.3832615945381613 0.5794597756013246 5.247909040538532 4.060228388511806 0.8696445876444047 0.3456413265115501 1.0 1.0 0.2534337902702077 0.0001434833065057 7.905535910051942e-05 +Abnormal pericardium morphology 3 10 2.183322355622148 0.029012079359548 3.487864077669903 10.762135922330096 1.0304485268572945 0.2849705132346721 1.7172308655515107 1.695717994097398 1.0794817436655069 0.2735310781030822 1.0 1.0 0.0042717712834537 0.0086864012748381 0.0784062010361378 +Arthritis 8 34 2.1822745695780696 0.029089274688008 10.45631067961165 41.12864077669903 0.9299077951686036 0.3844403642845474 3.7326340917241647 4.351147052994631 1.200139433310656 0.3557501916131977 1.0 0.4072806445693771 0.0006199102456503 0.001172923761026 0.0145010060309367 +Abnormal larynx morphology 2 21 2.1798500502101623 0.0292685785200585 6.839805825242719 27.718446601941743 0.5738284857128313 0.4761706892213789 2.8749956456134265 3.1319446353032743 0.987106786856402 0.3377886307734372 0.0204912599751884 0.0904452781629929 0.0820650305700749 0.4670496335734261 0.7497583054454451 +Mucosal telangiectasiae 3 7 2.1671160140416603 0.0302260091447108 3.2354368932038833 9.689320388349516 0.8501086222195428 0.291727970426265 1.410916714116348 1.5996305775803197 1.2598794700933909 0.2907637890882055 1.0 0.1263420182810564 0.0299460957191466 0.0042924995678 0.0432317268333426 +Generalized muscle weakness 7 28 2.1593064361878853 0.0308264011504886 7.728155339805825 32.1626213592233 0.5657235813512097 0.5484647799965952 3.662839300714657 2.6485498729392836 0.8197648550400668 0.3335986274065884 1.0 1.0 0.2210940975250464 0.0015514010815503 0.0117444524522708 +Hypothermia 1 7 2.1573954763251613 0.0309748634008442 2.4174757281553396 9.49271844660194 1.0856169578047503 0.2588610618328691 1.611694349619475 1.8201795996814751 1.0634596616937388 0.2538467530049644 1.0 0.1049896535105009 0.2012104780589677 0.1053546389470493 0.3038418993250599 +Arteriosclerosis 5 14 2.152883219018684 0.0313278576459672 4.885922330097087 14.944174757281552 0.0721468675738393 0.2032976413320727 1.852339343238996 2.0572604199467093 1.788928597657784 0.2405012300780825 1.0 0.2068720246529641 0.0111977735740575 0.0009743779436676 0.0075456004444188 +Epidermal acanthosis 0 8 2.15068514191039 0.0315010599006733 3.087378640776699 9.521844660194176 -0.1968593612572628 0.468167729423918 1.8635845828423945 1.433648511155872 1.0045877831038132 0.281519192096159 1.0 0.1135912525516411 0.2166826538338764 0.4573561220916043 0.7085155867377892 +Abnormality of glycolipid metabolism 2 6 2.1495757061176217 0.0315887917752348 3.83495145631068 7.228155339805825 0.3163887308740252 0.1681411938672545 1.311614193945771 0.5964160722258837 1.870431483654663 0.2292796295173983 1.0 1.0 0.0930016660897952 0.0014684283121974 0.0102762365494686 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20.01941747572815 0.4670703905456849 0.5376214087969519 2.554791232762714 1.8952192409705757 0.8387891641382008 0.309595447618788 1.0 1.0 0.0338721796728873 0.0018365459096632 0.023341028568652 +Abnormal form of the vertebral bodies 19 68 2.129132471434066 0.0332433019158249 19.968446601941743 83.88349514563107 0.6644002102675167 0.5345165392282933 7.187939907318809 8.37593753149639 0.9881357365384656 0.3722270618536288 0.0476744094319509 0.0063027604866577 0.0099144414073817 0.0161407084239078 0.0076091334619777 +Polyneuropathy 5 14 2.124688738154366 0.0336125937895654 5.689320388349515 18.633495145631063 1.1475655107151586 0.297256939859202 2.871111980426299 2.8359934163787166 1.1251440285742276 0.3008764483611514 1.0 1.0 0.3986935444378103 0.0362911702166911 0.0374739153185052 +Ectrodactyly 5 11 2.124253820275105 0.0336489249866829 4.12378640776699 15.87864077669903 0.8198140763126681 0.3757221931635416 2.0209382693093176 2.284355849612238 1.0264971379648948 0.291688305539228 1.0 1.0 0.0789500483472863 0.0009743779436676 0.0075456004444188 +Abnormality of the vasculature of the eye 15 64 2.1093771883353565 0.034912036916578 16.27912621359223 72.06553398058253 0.403343228775578 0.4479390001832676 5.629952078086087 5.671259209870798 1.3806507490937323 0.3789287537753926 1.0 0.2998540533025085 0.02342829326042 0.0012511485276846 0.0263598539532629 +Elevated pulmonary artery pressure 5 13 2.1081139808312925 0.035021131398099 7.422330097087379 24.033980582524272 0.8771466934674594 0.3206437689207037 3.083196929894625 3.78086786662344 1.283632173810104 0.3146045769490745 1.0 1.0 0.2139520870514039 0.0637395822669413 0.2559567804287034 +Abnormality of the biliary system 18 90 2.0981924350748296 0.0358881496168952 24.728155339805824 113.4878640776699 0.4226772043353868 0.5416117734931738 8.513489210598458 10.938368752781027 1.0946055307638114 0.3805906621326833 1.0 0.1288043366290671 0.0131575448938431 5.709861457667247e-05 0.0007309875928728 +Abnormal lower motor neuron morphology 3 8 2.0970049159438817 0.0359931401716537 2.1771844660194173 8.701456310679612 0.8468629004048428 0.2893246976958152 1.3759952567341256 1.207057649999096 1.1584035743641086 0.2695692447215745 1.0 1.0 0.2166826538338764 0.0028063338575205 0.0298799397306715 +Abnormal delivery 4 18 2.0948683558655468 0.0361826965471896 5.699029126213592 21.5873786407767 0.8953606264352741 0.420193574632847 2.851791981194637 2.0047603353673553 0.8292150006712276 0.3226752218541708 1.0 1.0 0.0876106046642714 0.0074685925596388 0.0968560278048493 +Mortality aging 22 83 2.086052135099072 0.0369739007680314 25.191747572815533 104.62135922330096 -0.006207101289445 0.6010003282911466 9.143655546432974 10.3112875325876 0.9630218641257098 0.3455719864134562 1.0 0.1151104414766776 0.218711052695476 0.0009456035437835 5.4056687298775766e-05 +Restlessness 11 35 2.080926323539133 0.0374406502931985 8.504854368932039 39.24271844660194 0.1249492740128899 0.6154777150489179 3.557089970251174 3.226004831545494 0.8088352215696927 0.3132120729514256 1.0 1.0 0.2318437245510384 0.0019103185828395 0.0017443747591126 +Abnormality of pancreas physiology 5 33 2.079533800192038 0.0375683144574334 8.33495145631068 41.74514563106796 0.2260468842809028 0.6100794420799563 3.683397775478612 4.537930832541139 0.7462521675115479 0.2917658993245175 0.0201029320171089 0.0131788445501069 0.0177897684291767 0.0382007550618062 0.1219034690910463 +Rhizomelia 4 10 2.075080067244321 0.0379791147651247 4.276699029126213 11.868932038834952 1.3783619481702345 0.228956695884812 2.09278482575067 1.6655579622091714 0.936017394236602 0.2616202806826952 1.0 0.1991580424676108 0.0733374275738533 0.0048028453089964 0.0218949055651906 +Abnormality of femur morphology 8 47 2.067817613417509 0.03865717679541 17.20873786407767 66.68203883495146 0.8363246416857221 0.4265359075043799 5.791282481104246 7.777760660479065 1.2398669594969238 0.3848538433547022 0.0378863630370249 0.0668873192346767 0.041094153442678 0.0197776675024878 0.0868216587291676 +Psychomotor deterioration 2 8 2.0645008375096983 0.0389702545732819 3.2645631067961167 8.910194174757281 0.9753014938956188 0.1960965459818884 1.3866235282600423 0.7031088807706056 1.4929387846379636 0.2609606457365817 1.0 0.0607401038440192 0.1191939669275513 0.0033170374819039 0.0220005392397008 +Toe walking 4 16 2.06291102956675 0.0391210820126679 6.740291262135922 22.805825242718445 1.1386089770349623 0.3130572717722256 3.272869930973316 2.572476621751866 1.068544148592376 0.2998505070337083 1.0 1.0 0.3927678686332497 0.0074685925596388 0.034492515261231 +Emg chronic denervation signs 5 10 2.062268645085812 0.0391821664599936 4.550970873786408 13.815533980582524 0.6176194543661773 0.3415909714455588 2.199917039284479 1.6085184210885628 1.2249413291120588 0.2985007469873863 1.0 1.0 0.208984012191681 0.0024022577840735 0.0007662488934102 +Clumsiness 6 17 2.0619358503165697 0.0392138438068043 6.75 20.57766990291262 0.9027704056640264 0.2559090219975202 2.4698423753801175 2.2221930931993956 1.527926415027724 0.282470536898918 1.0 1.0 0.0818055658939264 0.0010882828125207 0.0084488258349492 +Abnormal epidermal morphology 1 16 2.05981325832023 0.0394163965986922 4.716019417475728 17.939320388349515 0.174215235977072 0.5180036624559629 2.3595366666310484 1.948040470331747 0.9178221827497226 0.2842129908772916 1.0 0.1913705796369965 0.0678620701894922 0.2871762535363917 0.6317161202206396 +Cerebral inclusion bodies 6 12 2.051379711860586 0.0402299832266546 3.844660194174758 13.655339805825244 0.5051551663301821 0.4226246963159299 1.8115448621120656 1.6612796655742368 1.090041660052819 0.3107400387490911 1.0 1.0 1.0 0.0078094686864188 0.0008143039286516 +Abnormal tissue metabolite concentration 2 10 2.050320169169294 0.0403331976628389 5.895631067961165 14.650485436893204 0.4799987914691458 0.2340469593783387 2.3926019349714145 2.328417679576543 1.7567023743300048 0.2768423789344761 1.0 1.0 0.2756599666896902 0.0444854600227105 0.2100885178951895 +Abnormal circulating fatty acid anion concentration 7 14 2.0500839868583185 0.0403562357402209 3.4684466019417477 13.439320388349516 0.6959006280700144 0.4066366331458161 2.303748425990877 1.289881278600975 0.9955896787866196 0.2877623152669635 1.0 0.1006582454154426 0.0190005699483642 1.001077164406324e-05 4.729552973964105e-06 +Abnormal cranial nerve physiology 8 51 2.048611388355003 0.040500130151083 15.28640776699029 70.41019417475728 0.3474177643184146 0.6276590204132638 5.1247078731555415 8.772153257771443 0.7667367226441726 0.3323095327727143 0.0442255192051858 0.0962045324719342 0.02342829326042 0.1007206487772324 0.2078763692979986 +Muscle spasm 10 49 2.042410586577211 0.0411108204960342 12.46116504854369 57.41990291262136 0.5782385518256496 0.5270109112328661 4.685854213547734 5.0957713280196595 0.8793305042203639 0.3427211662973412 1.0 1.0 0.6980596213140103 0.000170845725604 0.0002336376849139 +Abnormality of the upper respiratory tract 11 78 2.038758224123083 0.0414741635837787 19.66504854368932 95.80582524271844 0.4534569687157453 0.5959175600884278 6.924659870205313 10.36312380503997 0.9632839800839448 0.3651113920771414 0.0572219514671371 0.1694970960273094 0.0249010677279274 0.0549915539276149 0.0477043223658178 +Platyspondyly 4 25 2.0372276967714176 0.0416272295424648 8.28640776699029 33.730582524271846 0.6662607465302498 0.4948187493576657 3.3732974430890796 4.074278380383408 0.9978722835718216 0.3450714604006198 1.0 0.0006546615435026 0.0012443166286699 0.0499487852123864 0.208479757572215 +Congestive heart failure 14 55 2.030363470562397 0.0423196069288969 13.735436893203884 61.70631067961165 0.0374429268338024 0.7117971406415442 6.533736687408398 4.475245719845195 0.6357585088219058 0.2862155515906742 1.0 0.1757629685498992 0.4557560675355755 0.0001135136162722 0.0002007162018065 +Neonatal hypoglycemia 3 8 2.025010258677093 0.0428663108423945 2.237864077669903 10.04368932038835 0.7747126119899399 0.4306543785319578 1.853027777096223 1.7524002902489448 0.8324785090654103 0.3000381254726006 1.0 0.1178616319260966 0.0260710687649276 0.0239571113561098 0.0340142536491894 +Abnormality of extrapyramidal motor function 14 61 2.020471083828352 0.0433345465945336 17.723300970873787 74.23058252427184 0.6611914449106878 0.5008095396366101 5.517064505158221 6.985611887807198 1.1554912414277594 0.3847143245763222 1.0 0.6312378177493598 0.320671241621328 0.0004400111129202 0.0020292280108345 +Aplasia hypoplasia involving the vertebral column 2 12 2.007327698822709 0.0447147817037452 4.679611650485437 14.847087378640778 0.8883735186508074 0.3527358077962234 2.3127489306396716 2.051146083169333 0.9597872998017484 0.2871451112966173 1.0 0.0180235679120217 0.0082729445560879 0.0846608217542885 0.0538789205814144 +Disproportionate short limb short stature 4 14 2.0070623242503904 0.0447430272292965 6.587378640776699 19.902912621359224 1.344701363676014 0.2682000023842777 2.8599402401133336 3.1206003999939886 0.9439707190715964 0.2973700803613334 1.0 0.2801168002074996 0.1411421437582085 0.0238750792658836 0.0440048441687529 +Short palpebral fissure 7 25 2.002219134011353 0.0452611686894099 6.29126213592233 27.92233009708738 0.3913672129346548 0.6272266742698988 3.03660857057613 3.451295860157005 0.6967404872312752 0.3059936066215196 0.0162154195614219 0.060198214592267 0.0467208448743291 0.0499487852123864 0.0454306863099482 +Loss of speech 4 16 1.9984660829884024 0.0456661534861255 5.453883495145631 19.1626213592233 0.4726173662677797 0.3013153148889984 2.223071754411353 1.8941045281154043 1.521023928928509 0.3006842241053739 1.0 0.1835089509173778 0.0625314301217693 0.0032221742646108 0.0143931802338971 +Abnormal cartilage morphology 2 9 1.9982700559190811 0.0456873900400822 3.1990291262135924 12.25242718446602 0.2463325696611419 0.4916908795514706 1.9381702483974472 1.2343658928045838 1.0349646859752573 0.2956464310458583 0.0056806937145166 0.000349084453734 0.0027014769688677 0.0319451393300601 0.1610434863229046 +Abnormality of the metaphysis 6 35 1.99324505661766 0.0462346195359082 9.87621359223301 51.49514563106796 0.3562011438392169 0.6166342982450355 4.530020385411355 8.226317920685393 0.7780483709827255 0.3214835918572445 1.0 0.0066943338481014 0.0041834474178984 0.0856589374667302 0.3420918954695657 +Ventricular tachycardia 2 9 1.987402124703448 0.0468778524262742 3.029126213592233 13.262135922330096 0.686137979317516 0.4029577645071625 1.751317455154925 1.7554971361746374 0.9579673572740748 0.2804177345045502 1.0 0.1221118561195742 0.2318581098993339 0.1374615323876937 0.138008760806013 +Cardiac conduction abnormality 6 19 1.985155853294268 0.0471271342614678 7.54126213592233 30.07766990291262 0.9307918135366152 0.3911403090848463 3.486554807604548 3.5456504747498965 0.9289536354013204 0.3216072900435658 1.0 0.3371313972628795 0.565173788309953 0.0543296939149059 0.1136586988698017 +Hepatic necrosis 3 9 1.9800464685970007 0.0476983074196624 3.0849514563106797 8.78883495145631 -0.2360939247565092 0.5184113252809801 2.025341094986612 0.6359547534904771 0.9180889033358086 0.2939072102435344 1.0 0.0561990347849709 0.0057815105752346 0.0001405335592956 0.0019152907278613 +Abnormality of pulmonary circulation 6 16 1.979005172472088 0.0478154239040131 8.439320388349515 28.538834951456312 0.8940347945025898 0.342085103264471 3.349932259027002 4.295622811850572 1.233599840087162 0.3264185554851845 1.0 1.0 0.0857236814467353 0.0446619282438801 0.2549188981524166 +Proportionate short stature 6 31 1.9733272999414968 0.0484582845270777 8.20873786407767 34.116504854368934 0.7111768198576495 0.4559300049156646 3.388318218343798 3.7920483254309434 0.966379822462628 0.3393663702605685 1.0 0.0933835795341615 0.0201682074965487 0.0147861479784934 0.0717381307100851 +Limb undergrowth 7 40 1.966913468334172 0.0491931875494435 10.648058252427184 51.10436893203884 0.3980398713744312 0.5752346762319336 4.664982243954684 7.303495661229484 0.9215304205365352 0.3350258300048305 0.0353833668332636 0.0111376955132978 0.0319499068250687 0.0736185453642521 0.3780140021928362 +Glutaric aciduria 1 5 1.963771209034229 0.0495566303450059 2.953883495145631 5.070388349514563 -0.7439973413085805 0.412964258453206 1.4039851277181692 0.4750031626467979 0.9287128633054128 0.3052431646176438 1.0 0.0378187125466048 0.075113296023457 0.0147480216610697 0.0532360743035436 +Hypoplastic vertebral bodies 1 5 1.9620286219853524 0.0497591520501856 1.9757281553398056 5.771844660194175 0.8508946908089206 0.2775138956505893 1.1057630163966317 0.6800795892498206 1.1536023105486033 0.2559235656158802 1.0 0.0017062060788896 0.0067896670197663 0.0379575415698398 0.0220005392397008 +Zonular cataract 1 8 1.9617515338392084 0.049791418822837 3.04126213592233 10.71359223300971 0.6482844736848132 0.4757859716104625 1.6665604248665455 1.9447488940504751 0.8413866153147622 0.3111450918700563 1.0 0.1093006244161378 0.208984012191681 0.1131762501747812 0.3218399169332961 diff --git a/msigdb_hp/metrics.json b/msigdb_hp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..b8cb9ee6b0c4ad244d7e553f9c093a85a922ea18 --- /dev/null +++ b/msigdb_hp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2454, + "annotations_size": 4423, + "title": "Average number of proteins per term", + "value": 19.19647298213882 +} \ No newline at end of file diff --git a/msigdb_hp/paths.json b/msigdb_hp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..d97deb0ec116046a667099365c5485b5e592cce0 --- /dev/null +++ b/msigdb_hp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_hp/fragment/C340/C340_val_log2fc"} \ No newline at end of file diff --git a/msigdb_hp/result.tsv b/msigdb_hp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..14fa7eb64dd57d5e6d726510e5a90249d7bedc5f --- /dev/null +++ b/msigdb_hp/result.tsv @@ -0,0 +1,1540 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Corneal opacity 0.6063364704928143 2.910438593763209 0.0036092188120868 0.9999998866122332 0.2167786961687932 41 Q15056,Q06136,P06280,O75844,O96028,P04062,P35250,P18074,P10619,Q9Y4P3,P16278,Q13510,Q9UBM7,Q99519 14 +Abnormal biliary tract morphology 0.735108036459772 2.775635953849278 0.0055093859600379 0.9999999999755744 0.2167786961687932 17 Q14108,P04062,Q5XKP0,P09601,Q14739 5 +Mental deterioration 0.4900324527682664 2.742114552613642 0.0061045048385093 0.9999999999982702 0.2167786961687932 81 P21964,P09651,P50897,P16278,Q9BQE5,P31483,Q13501,O75306,P05067,O43464,O75503,Q13510,Q14108,P61916,P18074,P00403,P17900,O15118,O95140,P04062,P22626,P35637,Q03164,P54802,Q5XKP0,Q9Y487,O43681 27 +Abnormality of the larynx 0.5946324993376887 2.7299143579896965 0.0063350780665594 0.99999999999938 0.2167786961687932 38 Q13501,Q9UHX1,Q92804,P35637,Q15165,Q13510,Q9UBM7,Q14739 8 +Skin nodule 0.7171791539277541 2.6771244384481867 0.0074257049921677 0.9999999999999952 0.2333648435461103 17 Q9NZ08,O75874,P35637,P48735,Q13510 5 +Abnormal vascular physiology 0.5858875937568561 2.6378431110714984 0.0083435172783432 1.0 0.2505809900808559 37 Q14108,Q9NZ08,O15460,Q15056,P05067,P06280,O75844,P04062,P35250,P00403,Q9Y4P3,P20674,Q9NWM8,Q14739 14 +Disproportionate short stature 0.7000875815798746 2.623642520481269 0.0086995039700523 1.0 0.2505809900808559 18 Q9UHX1,Q15392,Q03164,P16278,Q9UBM7,Q14739 6 +Abnormal larynx physiology 0.75044719379337 2.6218871497306333 0.0087444380748844 1.0 0.2505809900808559 14 Q92804,P35637,Q15165,Q13510,Q13501 5 +Subcutaneous nodule 0.7343570329913282 2.610638644451055 0.0090373330864605 1.0 0.2505809900808559 15 Q9NZ08,O75874,P35637,P48735,Q13510 5 +Xerostomia 0.733312831652234 2.6051194456091555 0.0091842235913943 1.0 0.2505809900808559 15 Q13501,Q92804,P35637,Q15165,Q14739 5 +Neonatal death 0.7581451394731233 2.5926699761423264 0.0095234108146287 1.0 0.2505809900808559 13 P13804,Q16134,P04062,Q9H0R6,Q14739 5 +Biliary tract abnormality 0.6792140490767686 2.5926007047557476 0.0095253289653829 1.0 0.2505809900808559 20 Q14108,P04062,Q5XKP0,P09601,O43681,Q14739 6 +Dysphagia 0.4451662303507149 2.590012135268672 0.0095972548668101 1.0 0.2505809900808559 101 Q01105,Q9UHX1,Q9NR77,P48735,P37198,Q13501,Q14739,O75306,P07737,P05067,Q8NFF5,O75874,Q13510,Q99720,Q8N0X7,Q99519,Q14108,Q9BUF5,P61916,Q15067,O15118,P04062,P35637,Q03164,Q9Y263 25 +Cherry red spot of the macula 0.8509209218081859 2.5860831947642944 0.0097073496908084 1.0 0.2505809900808559 9 P17900,P10619,Q13510,P16278 4 +Abnormal circulating lipid concentration 0.4935342740269313 2.5830668047712337 0.0097926359083209 1.0 0.2505809900808559 63 P28070,P06280,P35250,P31751,P40939,O75880,Q15392,Q15904,Q14739,O43772,P23786,Q15738,P61916,O75844,Q16836,P16219,Q9UBM7,O75431,Q15056,Q9Y4P3,O75648,Q13642 22 +Cerebral palsy 0.847459755854857 2.570897394694405 0.0101435374914811 1.0 0.2505809900808559 9 P48735,O75874,Q9BVA1 3 +Amyotrophic lateral sclerosis 0.7078804668073777 2.5445925705766426 0.0109405308527159 1.0 0.2505809900808559 16 P07737,Q92804,P22626,P35637,Q15165,Q99720,Q13501 7 +Motor neuron atrophy 0.6535347285665013 2.535347214471744 0.0112335919753456 1.0 0.2505809900808559 22 P07737,Q92804,P22626,P35637,Q15165,Q13510,Q99720,Q13501 8 +Respiratory failure 0.4999363939079638 2.5307268265915503 0.0113826460457491 1.0 0.2505809900808559 53 Q9Y619,O75306,P61916,P07737,Q92804,P23786,P35637,Q15165,P40939,Q5XKP0,Q13510,P10253,Q13501 13 +Abnormal vertebral morphology 0.4571718583971839 2.462783009132606 0.0137863322815876 1.0 0.2871155335230421 86 Q9Y619,Q9UHX1,P35250,Q6NUK1,P07237,P16278,P10644,P48735,Q14739,O75874,Q99519,Q14108,Q15738,O75718,P10619,Q9Y5S9,O95831,Q9UM00,Q96J02,Q9UBM7,Q15056,P61978,P04062,O96028,P54802,Q9Y4P3 26 +Hallucinations 0.5642881306881664 2.451630666144161 0.0142210543577443 1.0 0.2898604766096924 36 P04062,P35637,P50897,Q9BQE5,O75503,Q6DKK2,O43681,Q13501 8 +Dicarboxylic aciduria 0.6464334777461377 2.443597082870979 0.0145416565800664 1.0 0.2942340218780757 21 O43772,P13804,Q16134,P23786,Q16836,P40939,P48735 7 +Abnormal retinal artery morphology 0.6576174461561763 2.421152595577206 0.0154713812295634 1.0 0.3081124381952941 19 P17900,Q15056,P35250,P10619,P16278,Q13510,Q99519 7 +Abnormal arterial physiology 0.5980634847370174 2.3651492331542814 0.0180228069388292 1.0 0.3081124381952941 26 Q9NZ08,O15460,Q15056,P05067,P06280,O75844,P35250,Q9NWM8,Q14739 9 +Abnormality of head blood vessel 0.6330543597572755 2.3618982980926178 0.0181816292943639 1.0 0.3081124381952941 21 P17900,Q15056,P35250,P10619,P16278,Q13510,Q99519 7 +Heterogeneous 0.5596142219675246 2.3538112085376226 0.0185820459884795 1.0 0.3101448656869627 34 Q9Y619,P61916,P04792,P05067,O75844,Q9NR77,Q16836,P40939,Q9BQE5 9 +Abnormal neuron morphology 0.5914005547219652 2.3470991051348618 0.018920221515845 1.0 0.3131952351519528 27 P07737,Q92804,P22626,P35637,Q15165,Q13510,Q99720,Q13501 8 +Wide anterior fontanel 0.6717104545847233 2.344240733875612 0.019065860922057 1.0 0.3131952351519528 16 P13804,Q16134,O75718,Q14738,P20674,Q9Y487 6 +Fatigable weakness of swallowing muscles 0.7068476749550112 2.330011129620235 0.01980556289246 1.0 0.3133437767622385 13 P35637,Q15165,Q92804,Q13501 4 +Fatigable weakness of respiratory muscles 0.6945841108996661 2.32924565826018 0.0198460553745523 1.0 0.3133437767622385 14 P35637,Q15165,Q92804,Q13501 4 +Abnormality of the ribs 0.5110376958510974 2.3199272996554665 0.0203448104814301 1.0 0.319096087799168 46 Q9Y619,Q15738,Q9UHX1,O75718,O75844,O96028,P07237,P54802,Q03164,Q9Y5S9,P16278,Q9UM00,O95831,P15586,Q9UBM7,O75431,Q14739 17 +Proximal tubulopathy 0.6398733665837898 2.3159043859886763 0.0205634898049626 1.0 0.321386273524205 19 Q8IUX1,O75306,P13804,Q8N183,Q16134,P00403,O43676,Q9P032,Q9Y375 9 +Agitation 0.5685852649763271 2.309984080273628 0.0208890355060573 1.0 0.32263121756046 31 P48449,P07737,P05067,Q92804,P04062,O43464,P35637,P09651,Q15165,P42892,Q13501 11 +Increased bone mineral density 0.6076574938648645 2.298154849066153 0.021552977434208 1.0 0.3287200661775935 23 Q14108,Q15056,Q13126,P04062,P35250,P18074,Q15392,Q14739,Q13501 9 +Retinopathy 0.6147702441536547 2.2948864641253497 0.0217396317311726 1.0 0.3304274609861741 22 Q9NZ08,O75306,O96028,P07437,P18074,P40939,Q9Y375,Q99519 8 +Micromelia 0.636117783005414 2.293453115267274 0.0218219316683623 1.0 0.3305424786615293 19 Q9UHX1,Q9UBM7,O75874,P48735,Q15392,Q14739 6 +Neurodegeneration 0.5841921178775485 2.2720992387936736 0.0230805170862242 1.0 0.3351078883232989 26 P17900,Q92804,P35637,Q15165,Q6DKK2,Q13501 6 +Hypoglycemic coma 0.7802391281364836 2.2701184360869036 0.0232003980282329 1.0 0.3353443152904387 9 P13804,Q16134,P31751,Q16836,P40939 5 +Paraparesis 0.5951449285792033 2.267655228145227 0.0233502286979998 1.0 0.3364106238803041 24 Q9Y619,P04062,P35637,Q5XKP0,Q13510,Q6DKK2 6 +Low frustration tolerance 0.8473586161201362 2.261248297421463 0.0237438858757426 1.0 0.3409714520402908 7 Q03164,Q9UHX1,P04062 3 +Fatigable weakness of bulbar muscles 0.6806917668504211 2.2547879252919545 0.0241466435512573 1.0 0.3445180787974563 14 P35637,Q15165,Q92804,Q13501 4 +Respiratory distress 0.5189137206106424 2.2526973747686325 0.0242782365929061 1.0 0.3452818020913956 42 Q9Y619,O75306,Q9UHX1,P13804,Q16134,P04062,P23786,P16219,O95831,Q13510,P10253 11 +Abnormality of corneal stroma 0.7597995291141689 2.2490752719554683 0.0245077075043025 1.0 0.3474281740113145 10 P10619,Q13510,P04062,P16278 4 +Bulbar signs 0.7729839062859776 2.2369814683004576 0.0252875512588226 1.0 0.352108703847973 9 P35637,Q99720,P04062,O43681 4 +Abnormal rib cage morphology 0.4738690639041417 2.236417491464495 0.0253244364297511 1.0 0.352108703847973 52 Q9Y619,Q15738,Q9UHX1,O75718,O75844,O96028,P07237,P54802,Q03164,Q9Y5S9,P16278,Q9UM00,O95831,P15586,Q9UBM7,O75431,Q14739 17 +Hypoketotic hypoglycemia 0.841211715644892 2.235355828774311 0.0253939975497496 1.0 0.352108703847973 7 Q16836,O43772,P40939,P23786 4 +Dyspnea 0.4386052609703875 2.204531978136187 0.0274869535813773 1.0 0.3624354088659007 82 Q9Y619,O75306,Q9UHX1,P07737,P13804,Q16134,P06280,O75844,P04062,Q92804,P23786,P35637,Q15165,O95831,Q13510,P10253,Q13501 17 +Lymphangioma 0.9824632952691674 2.2025343585866346 0.0276275848855775 1.0 0.3624354088659007 2 P48735 1 +Hemangiomatosis 0.9824632952691674 2.2025343585866346 0.0276275848855775 1.0 0.3624354088659007 2 P48735 1 +Visceral angiomatosis 0.9824632952691674 2.2025343585866346 0.0276275848855775 1.0 0.3624354088659007 2 P48735 1 +Abnormal circulating fatty acid concentration 0.6336055547930053 2.201159791508939 0.0277247136714486 1.0 0.3624354088659007 17 O43772,P23786,Q16836,P16219,P40939,O75880,O75648,O75431 8 +Vascular neoplasm 0.5697755703317354 2.199465603770258 0.0278448322990483 1.0 0.3624354088659007 27 P48735,P10619,Q9UHX1,O75874 4 +Abnormal periventricular white matter morphology 0.5529869842826768 2.1975960560932246 0.0279779045335335 1.0 0.3624354088659007 31 P17900,Q9UHX1,O96028,P18074,O75503,O43681 6 +Periventricular white matter hyperintensities 0.8858064083203965 2.197172161182038 0.028008153009112 1.0 0.3624354088659007 6 O75503,P17900 2 +Dementia 0.47886248689803 2.1928562107117218 0.0283177405266767 1.0 0.3630416415927289 50 Q14108,P17900,P61916,P05067,P04062,P22626,P35637,P00403,Q9Y487,Q13510,P31483,O43681,Q13501 13 +Biliary cirrhosis 0.9069623936817937 2.188204587834814 0.0286547030779265 1.0 0.3660074014633573 5 P09601 1 +Paralysis 0.5143767028831511 2.1864399915577324 0.0287834304719658 1.0 0.3660074014633573 41 P17900,P04792,Q92804,P04062,P35637,Q15165,Q9NR77,P10253,Q13501 9 +Abnormal pericardium morphology 0.745804756428922 2.1833223556221477 0.029012079359548 1.0 0.3676053198430273 10 Q9NZ08,O15460,Q14108 3 +Arthritis 0.5367497316630174 2.1822745695780696 0.029089274688008 1.0 0.3676053198430273 34 Q14108,Q9NZ08,P28070,O15460,O75844,P04062,Q13510,Q14739 8 +Abnormal larynx morphology 0.6037164477592626 2.1798500502101623 0.0292685785200585 1.0 0.3688174438581743 21 Q9UHX1,Q14739 2 +Mucosal telangiectasiae 0.8250996183238081 2.1671160140416603 0.0302260091447108 1.0 0.3758464407645656 7 P06280,P10619,Q14739 3 +Generalized muscle weakness 0.5601592642571969 2.1593064361878853 0.0308264011504886 1.0 0.3808524365603665 28 Q92804,P35637,Q15165,O95831,P40939,P10253,Q13501 7 +Hypothermia 0.8228147596113519 2.1573954763251613 0.0309748634008442 1.0 0.3816206708131864 7 O43772 1 +Arteriosclerosis 0.6618809701008339 2.1528832190186837 0.0313278576459672 1.0 0.3830660931651893 14 P61916,O75844,P16278,Q13510,Q99519 5 +Abnormality of glycolipid metabolism 0.8739574673996872 2.1495757061176217 0.0315887917752348 1.0 0.3830660931651893 6 P17900,O43681 2 +Schizophrenia 0.6612209342868207 2.149284808752692 0.0316118299808487 1.0 0.3830660931651893 14 P04062,Q9BQE5 2 +Abnormal circulating acetylcarnitine concentration 0.8178002061178566 2.1360241727877 0.032677443565209 1.0 0.3910590507854113 7 Q16836,O43772,P40939,P23786 4 +Cognitive impairment 0.421989861091932 2.1342579710446365 0.032821669638712 1.0 0.3910590507854113 135 Q9Y619,P21964,P06280,P09651,P50897,P16278,Q9BQE5,P10644,P31483,Q13501,O75306,P05067,O43464,Q969G3,O75503,Q13510,Q99720,Q8N0X7,Q14108,P61916,Q9BVA1,P18074,P00403,O95831,Q6DKK2,Q9NZ08,P17900,O15118,O95140,P04062,P35270,P22626,P35637,Q03164,Q9Y263,P54802,Q5XKP0,Q9Y487,O43681 39 +Metaphyseal cupping 0.9657422512234894 2.1333416622762535 0.0328967088905243 1.0 0.3910590507854113 2 Q14739 1 +Prominent sternum 0.965742251223489 2.133341662276251 0.0328967088905245 1.0 0.3910590507854113 2 P16278 1 +Tissue ischemia 0.6092886553252792 2.1312668041406524 0.0330671682102066 1.0 0.3910590507854113 19 Q9NZ08,O15460,Q15056,P05067,P06280,O75844,P35250 7 +Abnormal form of the vertebral bodies 0.4446027501718866 2.129132471434066 0.0332433019158249 1.0 0.3916557768844699 68 Q9Y619,Q9UHX1,P35250,Q6NUK1,P07237,P16278,P10644,P48735,Q14739,O75874,Q99519,Q9UM00,O95831,Q96J02,Q9UBM7,Q15056,O96028,P54802,Q9Y4P3 19 +Polyneuropathy 0.6567169845454137 2.124688738154366 0.0336125937895654 1.0 0.3916557768844699 14 O95721,P31930,Q15041,O95831,Q15120 5 +Ectrodactyly 0.7121013349299659 2.124253820275105 0.0336489249866829 1.0 0.3916557768844699 11 P48449,P04792,Q99720,Q9NR77,Q9UBM7 5 +Abnormality of the vasculature of the eye 0.4454689505853937 2.1093771883353565 0.034912036916578 1.0 0.4012913579631918 64 Q9NZ08,Q99519,P28070,O75306,P17900,Q15056,P06280,P35250,P18074,P10619,Q15555,P16278,Q13510,Q8WYQ5,Q14739 15 +Elevated pulmonary artery pressure 0.6647869728837342 2.1081139808312925 0.035021131398099 1.0 0.4012913579631918 13 Q14108,P04062,O75844,P00403,P20674 5 +Increased cerebral lipofuscin 0.9168135223734118 2.0993942280951243 0.0357821630846146 1.0 0.4078982147506462 4 P50897 1 +Abnormality of the biliary system 0.419727224552241 2.0981924350748296 0.0358881496168952 1.0 0.4080547191658807 90 Q14108,P61916,P13804,Q15056,Q16134,P04062,O96028,P35250,P00374,Q9Y4P3,P40939,P09601,Q5XKP0,Q13510,Q9UBM7,Q15904,O43681,Q14739 18 +Abnormal lower motor neuron morphology 0.7575743354505154 2.0970049159438817 0.0359931401716537 1.0 0.4081991255877555 8 P35637,Q13510,Q13501 3 +Abnormal delivery 0.609573877132696 2.0948683558655468 0.0361826965471896 1.0 0.4082552725209688 18 Q9Y619,Q9Y487,Q9UBM7,O75844 4 +Mortality aging 0.4268718339684829 2.086052135099072 0.0369739007680314 1.0 0.4150648809568603 83 O95721,P35250,Q6NUK1,P16278,Q15904,Q14739,P05067,Q16134,O43464,Q15738,P13804,O75718,O75844,P18074,Q9Y5S9,P20674,Q15067,Q00059,Q15056,P04062,Q9Y4P3,Q9H0R6 22 +Restlessness 0.518591557976111 2.0809263235391335 0.0374406502931985 1.0 0.4181818087040837 35 P48449,P07737,P05067,Q92804,P04062,O43464,P35637,P09651,Q15165,P42892,Q13501 11 +Abnormality of pancreas physiology 0.527957495146612 2.079533800192038 0.0375683144574334 1.0 0.4185350842608633 33 Q9NZ08,Q9UHX1,P09601,Q15904,Q14739 5 +Rhizomelia 0.7230031965831489 2.075080067244321 0.0379791147651247 1.0 0.4199540615153666 10 Q03164,Q9UBM7,Q15392,Q14739 4 +Abnormality of femur morphology 0.4781754166915831 2.0678176134175095 0.03865717679541 1.0 0.4252206202350305 47 Q9Y619,Q9UHX1,O75844,P04062,P16278,O95831,Q9Y487,Q14739 8 +Psychomotor deterioration 0.7504362987032481 2.0645008375096983 0.0389702545732819 1.0 0.4252206202350305 8 Q03164,P50897 2 +Toe walking 0.6223981031279684 2.06291102956675 0.0391210820126679 1.0 0.4252206202350305 16 P35637,O95831,P40939,O43681 4 +Emg chronic denervation signs 0.7203234574865742 2.062268645085812 0.0391821664599936 1.0 0.4252206202350305 10 O95140,P04792,P22626,Q13510,O43681 5 +Clumsiness 0.6100656245564204 2.0619358503165697 0.0392138438068043 1.0 0.4252206202350305 17 Q9NR77,Q15067,O75503,Q13510,O43681,Q13501 6 +Abnormal epidermal morphology 0.6218642865561296 2.05981325832023 0.0394163965986922 1.0 0.4252206202350305 16 Q06136 1 +Atrioventricular canal defect 0.9061731440042218 2.057363497056574 0.0396512736656613 1.0 0.4252206202350305 4 Q9UHX1 1 +Cerebral inclusion bodies 0.6761005732061238 2.051379711860586 0.0402299832266546 1.0 0.4252206202350305 12 P61916,O15118,P05067,P04062,P22626,P31483 6 +Abnormal tissue metabolite concentration 0.7178277823441251 2.050320169169294 0.0403331976628389 1.0 0.4252206202350305 10 P17900,O43681 2 +Abnormal circulating fatty acid anion concentration 0.6431353946862987 2.0500839868583185 0.0403562357402209 1.0 0.4252206202350305 14 O43772,P23786,Q16836,P16219,P40939,O75880,O75648 7 +Abnormal cranial nerve physiology 0.4588539143829672 2.048611388355003 0.040500130151083 1.0 0.4252206202350305 51 Q9NZ08,Q9BUF5,Q9UHX1,O75874,Q9NR77,P48735,Q13510,Q13501 8 +Angiokeratoma 0.9441272430668805 2.043336950956805 0.041019094135857 1.0 0.4252206202350305 2 P16278 1 +Muscle spasm 0.4670462996246208 2.042410586577211 0.0411108204960342 1.0 0.4252206202350305 49 P04792,P07737,P06280,Q92804,P04062,P35637,Q15165,Q9NR77,P40939,Q13501 10 +Abnormality of the upper respiratory tract 0.4277059321396104 2.038758224123083 0.0414741635837787 1.0 0.4252206202350305 78 Q13501,O15460,Q9UHX1,P28070,Q92804,P35637,Q15165,P16278,Q13510,Q9UBM7,Q14739 11 +Platyspondyly 0.5530930336962709 2.0372276967714176 0.0416272295424648 1.0 0.4252206202350305 25 P48735,O75874,P16278,Q14739 4 +Congestive heart failure 0.4423318859625235 2.030363470562397 0.0423196069288969 1.0 0.4252206202350305 55 O75306,Q15056,O95721,P06280,P07437,P35250,P22626,P00403,Q15555,P16278,P40939,P10253,Q9Y375,Q70HW3 14 +Neonatal hypoglycemia 0.74179937407224 2.025010258677093 0.0428663108423945 1.0 0.4252206202350305 8 Q16836,O43772,P40939 3 +Increased c peptide level 0.9396411092985296 2.0245803127813957 0.04291047749655 1.0 0.4252206202350305 2 Q16836 1 +Abnormality of extrapyramidal motor function 0.4385755268740102 2.020471083828352 0.0433345465945336 1.0 0.4259304435280493 61 P17900,Q15056,P05067,P31930,P04062,P35270,P35250,P18074,P35637,P16278,O14949,Q99720,Q6DKK2,Q13501 14 +Patchy changes of bone mineral density 0.8959790395175393 2.0169364813913813 0.0437021423612513 1.0 0.4281072643997573 4 Q13126,Q14739 2 +Fractures of the long bones 0.9355628058727544 2.0075066986574477 0.044695738093424 1.0 0.430725210502453 2 Q13126 1 +Aplasia hypoplasia involving the vertebral column 0.6675982954103714 2.007327698822709 0.0447147817037452 1.0 0.430725210502453 12 P16278,Q14739 2 +Disproportionate short limb short stature 0.635357010820683 2.0070623242503904 0.0447430272292965 1.0 0.430725210502453 14 Q03164,Q9UBM7,Q15392,Q14739 4 +Short palpebral fissure 0.5479950255194532 2.002219134011353 0.0452611686894099 1.0 0.4317224888347334 25 Q9Y619,Q9UHX1,O75844,P07437,Q6NUK1,Q03164,Q15555 7 +Loss of speech 0.6113323187520373 1.9984660829884024 0.0456661534861255 1.0 0.432709477831443 16 P17900,P50897,O43681,Q13501 4 +Abnormal cartilage morphology 0.7215481940291222 1.9982700559190816 0.0456873900400822 1.0 0.432709477831443 9 P48735,Q9UHX1 2 +Abnormality of the metaphysis 0.5073749360284784 1.9932450566176596 0.0462346195359082 1.0 0.4369566713831669 35 Q13126,O75874,P16278,O95831,P48735,Q14739 6 +Ventricular tachycardia 0.719239819499971 1.987402124703448 0.0468778524262742 1.0 0.437906123610236 9 O43772,P23786 2 +Cardiac conduction abnormality 0.5855567874132164 1.985155853294268 0.0471271342614678 1.0 0.437906123610236 19 O75306,O43772,P06280,P23786,P00403,P04899 6 +High frequency sensorineural hearing impairment 0.887276325978263 1.982302519922 0.0474453921722524 1.0 0.4386291186065856 4 Q13510,O75844 2 +Hepatic necrosis 0.7176790457449048 1.9800464685970007 0.0476983074196624 1.0 0.4386291186065856 9 Q16134,Q16836,P40939 3 +Abnormality of pulmonary circulation 0.6080068661003505 1.9790051724720876 0.0478154239040131 1.0 0.4386291186065856 16 Q9NZ08,Q14108,P04062,O75844,P00403,P20674 6 +Proportionate short stature 0.522460017868001 1.9733272999414968 0.0484582845270777 1.0 0.4386291186065856 31 Q9Y619,P10619,Q16836,P16278,P40939,Q14739 6 +Limb undergrowth 0.4909814752338017 1.966913468334172 0.0491931875494435 1.0 0.4402771959607627 40 Q9UHX1,Q9UBM7,O75874,Q03164,P48735,Q15392,Q14739 7 +Glutaric aciduria 0.8511305486422189 1.963771209034229 0.0495566303450059 1.0 0.440454890906816 5 Q16134 1 +Hypoplastic vertebral bodies 0.8507019427189222 1.9620286219853524 0.0497591520501856 1.0 0.440454890906816 5 P16278 1 +Zonular cataract 0.7280433082985869 1.9617515338392084 0.049791418822837 1.0 0.440454890906816 8 Q8WWV3 1 +Retrocollis 0.9241435562805848 1.959590998654675 0.0500436143111402 1.0 0.4410358606704648 2 P35637 1 +Central scotoma 0.776699839387449 1.95892167466358 0.0501219602581752 1.0 0.4410358606704648 7 O75306,Q9H061,Q8WWV3 3 +Orthostatic hypotension due to autonomic dysfunction 0.7760543465108685 1.9561129798042187 0.0504518464515928 1.0 0.4410358606704648 7 P04062 1 +Vacuolated lymphocytes 0.922512234910272 1.9527329914908496 0.0508512422563549 1.0 0.4427461505902716 2 P16278 1 +Reduced consciousness confusion 0.3960373752632912 1.9402744846644553 0.0523463405473543 1.0 0.4513213727893726 98 Q9Y619,P40939,Q9Y375,O75306,O43772,P05067,Q16134,P23786,P13804,P18074,P00403,Q16836,P16219,O43676,Q9UBM7,Q9NZ08,P04062,P35270,O43681 19 +Decreased plasma carnitine 0.6543697462034291 1.938345483042027 0.0525810868394067 1.0 0.4523833895027859 12 O43772,P23786,Q16836,P40939,O75880,O75648 6 +Skin ulcer 0.5386359479312645 1.9375833315493871 0.052674077683458 1.0 0.4523833895027859 25 P48735,O15460,O75874,Q14739 4 +Prenatal maternal abnormality 0.6940662014610841 1.9357389803199871 0.0528996777192372 1.0 0.4528129883698199 10 O43772,Q14739 2 +Hepatomegaly 0.4075766723795559 1.9319502423109691 0.0533656476282631 1.0 0.4538771108507285 138 Q9Y619,Q9UJS0,P28070,P08236,Q658P3,Q6NUQ1,Q01844,P31751,P16278,P09601,P40939,O75880,P15586,Q15904,Q9Y375,Q14739,O75306,O43772,Q16134,P23786,Q13510,Q9Y3E5,Q99519,Q14108,Q8IUX1,P61916,P13804,O75340,Q96EY8,Q9HC21,P00374,P20674,O43676,Q15067,Q96J02,O75431,O15118,O95140,Q9NPL8,P04062,P54802,Q9P032,Q07021,O75648,P10253,Q8N183 46 +Abnormal umbilicus morphology 0.4773450689947044 1.9309319335137385 0.0534914704720064 1.0 0.4538771108507285 43 Q99519,Q15056,O75844,P07437,P35250,Q6NUK1,P18074,Q15555,Q9Y4P3,Q9NWM8,Q9Y487,Q8WYQ5,Q14739 13 +Abnormal heart valve morphology 0.4316940159061097 1.9309225971652615 0.0534926252219434 1.0 0.4538771108507285 57 Q9UHX1,P21964,Q8NCH0,P06280,P35250,Q6NUK1,P16278,P10644,Q6ZXV5,O75844,Q13363,P37268,O75431,Q15056,P61978,O96028,P04062,Q14738,Q9Y4P3,Q06787 20 +Abnormal conjunctiva morphology 0.5509546743493902 1.9269172346177357 0.053989945292626 1.0 0.4565918317959558 23 Q9NZ08,P28070,P06280,P10619,Q13510,Q14739 6 +Abnormality of the anterior fontanelle 0.5360413408134169 1.9195806417767216 0.054910891183677 1.0 0.4613542476073444 25 Q9Y619,P13804,Q16134,O75718,Q14738,P20674,Q9Y487 7 +Elevated circulating glutaric acid concentration 0.8710602398916452 1.91747573354264 0.0551775209597575 1.0 0.4613542476073444 4 Q16134 1 +Hyporeflexia of upper limbs 0.9131321370309948 1.9132387092488412 0.0557175000867329 1.0 0.4623611686371853 2 Q9NR77 1 +Toxemia of pregnancy 0.837323470052084 1.9074898090246573 0.0564571894692671 1.0 0.4673010266724022 5 Q14739 1 +Abnormality of salivation 0.4917134475654423 1.906326585434643 0.0566078470744106 1.0 0.4673010266724022 37 Q9BVA1,Q92804,P35637,Q15165,Q9NR77,Q14739,Q13501 7 +Rimmed vacuoles 0.6271689698585317 1.9046086897298495 0.0568309561779334 1.0 0.4680881176443195 13 P22626,O14979,Q13642,P31483,Q13501 5 +Abnormal middle phalanx morphology of the hand 0.7636716035977718 1.9020725859342087 0.0571616658285687 1.0 0.4690650240440808 7 Q9UHX1 1 +Pedal edema 0.835443037974678 1.8998015887282576 0.057459162374851 1.0 0.4697631703955012 5 Q14108,Q9Y5S9,P04062,Q9Y263 4 +Epiphyseal stippling 0.6841744408873965 1.8876070611175824 0.0590787214404975 1.0 0.4793610897021733 10 Q15738,P10644,O00116,Q9UBM7,Q14739,Q99519 6 +Generalized hirsutism 0.5639172099545401 1.886890691478875 0.0591750293867028 1.0 0.4793610897021733 20 Q06136,P07437,Q03164,Q15555,Q9BW83 5 +Macrovesicular hepatic steatosis 0.8082843748726766 1.881269070049501 0.0599353262131128 1.0 0.4816956679827865 6 O75648,Q5XKP0,Q9Y375,P23786 4 +Abnormality of exocrine pancreas physiology 0.5913896353015082 1.8811106089263223 0.0599568741554223 1.0 0.4816956679827865 16 Q9UHX1,P09601 2 +Blepharophimosis 0.4799869407527296 1.8750446651201964 0.0607865790932624 1.0 0.4816956679827865 40 Q9Y619,Q15056,P38159,O75844,P07437,P35250,Q03164,Q15555,O60701,Q9Y4P3,O75648,Q8WYQ5 12 +Metaphyseal widening 0.6114923556740391 1.873738933251058 0.0609664169230721 1.0 0.4816956679827865 14 P16278,Q14739 2 +Aortic valve stenosis 0.8290403305479347 1.8735830150956048 0.0609879208840968 1.0 0.4816956679827865 5 O75844,P16278 2 +Abnormally lax or hyperextensible skin 0.496509973274193 1.871991237683587 0.0612078157702 1.0 0.4825707115001691 34 Q9UHX1,Q15056,P04062,P07437,P35250,Q15555,Q9Y4P3,Q9NWM8,Q9Y487,Q15904 10 +Abnormality of the tarsal bones 0.5487958052075903 1.8690208955837615 0.0616199073079184 1.0 0.4826879968086534 22 Q9UHX1,O75844,P40939,Q14739 4 +Exaggerated startle response 0.7080097968614653 1.8688403258163784 0.0616450326017958 1.0 0.4826879968086534 8 P16278 1 +Hypergonadotropic hypogonadism 0.6803106918531555 1.8687384103963305 0.0616592173178587 1.0 0.4826879968086534 10 Q16740,P48449 2 +Upper limb asymmetry 0.9017128874388192 1.865023761841688 0.0621780736002808 1.0 0.4850328386843776 2 P07437 1 +Fasciculations 0.5217632983934054 1.8623119447079235 0.0625591327797541 1.0 0.4864197848947698 27 P07737,P04792,Q96GM8,P06280,P35637,O95831,Q13510,Q13501 8 +Chronic diarrhea 0.6396201858081095 1.86080239436694 0.0627720872592842 1.0 0.4864197848947698 12 P18074,Q13510,Q15904,Q14738 4 +Bone pain 0.5710310640407946 1.8591377827907885 0.0630076109848101 1.0 0.4867100049961553 18 Q14108,P48735,P04062,O75874 4 +Dysostosis multiplex 0.7535033373412747 1.8574715047249597 0.0632441016110323 1.0 0.4867100049961553 7 P54802,P10619,P16278,P15586,Q99519 5 +Abnormality of skull ossification 0.6386577957785555 1.8557199727188989 0.0634934824514541 1.0 0.4867100049961553 12 O75718,O75844,Q9HC21,Q6NUK1,P54802,Q14739 6 +Confusion 0.6078870607536577 1.8534245359014427 0.0638215332593385 1.0 0.4875995598093373 14 Q9Y619,Q9NZ08,P05067,Q16836,P40939 5 +Mitochondrial inheritance 0.898858075040784 1.852947783970273 0.0638898432132393 1.0 0.4875995598093373 2 P00403 1 +Abnormal arachnoid mater morphology 0.8007860966937578 1.850163940211744 0.0642899245126162 1.0 0.4888201383221885 6 Q9UHX1,Q15904 2 +Abnormal c peptide level 0.8538382882521476 1.8482242791327388 0.06456990450204 1.0 0.4892599696549959 4 Q16836 1 +Abnormal placenta morphology 0.7494494652425755 1.8396342383645583 0.0658219541825102 1.0 0.4941403452457162 7 P16278 1 +Abnormal csf protein level 0.687347561317304 1.835917729963703 0.0663698250611153 1.0 0.4959206406807529 9 Q9NR77,O15382,O43681 3 +Hyperintensity of cerebral white matter on mri 0.6047779563167184 1.8358699167402392 0.0663768978709034 1.0 0.4959206406807529 14 O75503,P17900,P10253 3 +Ethylmalonic aciduria 0.8185021451624085 1.8302944579228897 0.0672059196643442 1.0 0.4979698728045716 5 Q16134,P13804 2 +Respiratory arrest 0.8485353783258403 1.8268197685248715 0.0677268725673245 1.0 0.4985194193199805 4 O43772 1 +Osteoarthritis 0.6854027160336825 1.82660065104132 0.0677598354314183 1.0 0.4985194193199805 9 Q14108,O75844 2 +Abnormal circulating free fatty acid concentration 0.8482536413992724 1.825681532637244 0.0678982465034301 1.0 0.4985194193199805 4 Q16836,P40939 2 +Abnormality of the mitochondrion 0.4092055547958089 1.823182811145498 0.0682757075422566 1.0 0.4985194193199805 77 O75306,O43772,P13804,Q70HW3,Q16134,P23786,P35637,P00403,Q16836,P20674,P40939,O43676,O75648,Q9H0R6,Q9Y375,Q13501 16 +Aplasia hypoplasia of toe 0.5159956624447217 1.8209391039758072 0.0686161141576822 1.0 0.4985194193199805 27 Q9UHX1,O96028,Q13363,O96019,Q03164,P10644,O75648,Q13510,Q9UBM7 9 +Abnormal morphology of the conjunctival vasculature 0.8158843363677554 1.81951535490425 0.0688328423767725 1.0 0.4985194193199805 5 P06280,P10619 2 +Avascular necrosis 0.5646366411870037 1.8194178871357465 0.0688476998204836 1.0 0.4985194193199805 18 Q9NZ08,Q14108,P04062,O75844 4 +Abnormal glial cell morphology 0.461175291386567 1.8182539564450388 0.0690253266355509 1.0 0.4985194193199805 44 O75306,Q16134,O75874,P04062,P35637,O95831,P48735,Q13501 8 +Abnormal light and dark adapted electroretinogram 0.7927306482905089 1.8166445241252849 0.0692715612564243 1.0 0.4985194193199805 6 Q15555,P50897,Q15067 3 +Abnormal full field electroretinogram 0.7927306482905089 1.8166445241252849 0.0692715612564243 1.0 0.4985194193199805 6 Q15555,P50897,Q15067 3 +Progressive psychomotor deterioration 0.7440696418454553 1.8159142354063869 0.0693835292733162 1.0 0.4985194193199805 7 P16278 1 +Crumpled long bones 0.8898858075040799 1.8149393304687913 0.0695332334965752 1.0 0.4985194193199805 2 O75718 1 +Capillary hemangioma 0.8147268044804271 1.8147458747676848 0.069562971635658 1.0 0.4985194193199805 5 Q9UHX1 1 +Thin ribs 0.6500481213518126 1.812908012229807 0.0698460102657201 1.0 0.4985194193199805 11 O75844,O95831 2 +Parathyroid adenoma 0.8135751394726727 1.809998617737022 0.0702960015238607 1.0 0.4985194193199805 5 P48735 1 +Abnormality of the parathyroid morphology 0.8135751394726727 1.809998617737022 0.0702960015238607 1.0 0.4985194193199805 5 P48735 1 +Neoplasm of the parathyroid gland 0.8135751394726727 1.809998617737022 0.0702960015238607 1.0 0.4985194193199805 5 P48735 1 +Ventricular hypertrophy 0.4964719600823699 1.8071236666871255 0.0707429993153359 1.0 0.4985194193199805 32 O43772,P06280,P10253,O75844,P23786,Q6NUK1,P00403,P78536,P40939,O75880,Q07021,Q13642,P12235,Q15233,O75431 15 +Pulmonary hypoplasia 0.5569295653091043 1.805604269607388 0.0709801752839898 1.0 0.4985194193199805 19 P13804,Q16134,O75844,Q6NUK1,Q9UBM7,Q14739 6 +Osteolysis 0.5453360824350338 1.8055732065699357 0.0709850309773632 1.0 0.4985194193199805 21 Q14108,O75874,O75844,P04062,P48735,Q13501 6 +Heart block 0.5886122333188015 1.801772117891257 0.0715812662051289 1.0 0.4985194193199805 15 P04899,P06280,O43772,P23786 4 +Raynaud phenomenon 0.7887086576831632 1.7998693322597958 0.0718812731299303 1.0 0.4985194193199805 6 Q14739 1 +Weakness of long finger extensor muscles 0.8849918433931445 1.7941732835608517 0.0727855149939011 1.0 0.4985194193199805 2 Q13501 1 +Abnormal atrioventricular valve physiology 0.4793423862671304 1.7872820905595952 0.0738919071467474 1.0 0.4988694486879638 36 Q9NZ08,O75306,Q15056,P06280,O75844,P04062,P35250,Q6NUK1,Q9Y4P3,P40939,Q13642,Q15904,O75431 13 +Reduced visual acuity 0.3886869210245376 1.7861376001379614 0.0740769814718287 1.0 0.4988694486879638 94 Q9NZ08,P17900,Q9UHX1,Q8WWV3,P50897,Q9H061,P16278,O43676,Q9Y375,O43681,P68371 11 +Abnormal sternum morphology 0.3992326889613404 1.781593545441326 0.0748155377693622 1.0 0.4988694486879638 84 Q9Y619,Q99519,Q9UHX1,Q15056,O75718,P04062,O96028,P07437,P35250,Q03164,Q15555,P16278,O95831,Q9Y487,Q13510,Q14739 16 +Sclerocornea 0.7361245160734012 1.780783778392085 0.0749477804593239 1.0 0.4988694486879638 7 Q6NUK1,Q9UBM7,O96028 3 +Insidious onset 0.8369323199198807 1.77985738362824 0.0750993036207554 1.0 0.4988694486879638 4 P04062 1 +Pelvic kidney 0.6888552375408639 1.7791554598651411 0.0752142783016363 1.0 0.4988694486879638 8 P35250,Q9UHX1,Q15056 3 +Abnormal cornea morphology 0.3837974464347758 1.774204882767202 0.0760292668550457 1.0 0.4988694486879638 116 Q06136,P06280,P35250,P16278,Q14739,P07437,Q9NWM8,Q13510,Q8WYQ5,Q99519,O75844,P18074,P10619,Q9UBM7,Q96EK5,Q9NZ08,Q15056,P04062,O96028,Q14738,Q15555,Q9Y4P3,O75648 23 +Variable expressivity 0.4156948716361478 1.7741022396743604 0.0760462404020176 1.0 0.4988694486879638 59 P17900,Q9BUF5,Q9BVA1,P35270,P00374,Q9NR77,P00403,Q9H061,Q13510,Q9Y375 10 +Abnormality of the gastric mucosa 0.5837809630183537 1.7736173709295882 0.0761264623857691 1.0 0.4988694486879638 15 Q15056,P04062,Q14739,P35250 4 +Joint stiffness 0.4382981501726024 1.77279667193323 0.0762624050960201 1.0 0.4988694486879638 49 O15460,Q15056,O95140,O75844,O75874,P35250,P18074,P54802,Q9Y4P3,P16278,P48735,P51648,Q13642,O75431 14 +Exostoses 0.9513492872510284 1.7701161158999756 0.0767077993868983 1.0 0.4988694486879638 3 P48735 1 +Hyperinsulinemic hypoglycemia 0.781408765577422 1.7693565832019096 0.0768343862450615 1.0 0.4988694486879638 6 Q16836 1 +Postural tremor 0.5924128166624882 1.7657264172653486 0.0774417585618323 1.0 0.500204679512505 14 Q14108,Q9NR77,P35637 3 +Ragged red muscle fibers 0.6213500248979301 1.7638467820381425 0.0777577787494419 1.0 0.5013449787300022 12 P00403,O95831,Q9H2D1,O75648,Q70HW3 5 +Dilated cardiomyopathy 0.4971742548367707 1.7558603835492723 0.0791122508841437 1.0 0.5026350838666592 30 O75306,P23786,Q16836,P16278,P40939 5 +Decerebrate rigidity 0.946470433237478 1.751417981810341 0.0798739378030344 1.0 0.5026350838666592 3 P16278 1 +Pain 0.3954354385681197 1.7493868224844442 0.0802241771337854 1.0 0.5026350838666592 142 P28070,P21964,P06280,Q92804,P35250,Q01844,P09651,Q9NR77,Q13423,P40939,P48735,P42892,Q13501,Q14739,P07737,O75874,Q8NFH4,P23786,Q02978,Q15165,Q969G3,Q13510,Q14108,O75844,P18074,Q70HW3,Q9NZ08,O15460,Q15056,O95140,P04062,P22626,P35637,Q9Y4P3,Q13642 35 +Abnormal oral physiology 0.4394553969360523 1.747829812837015 0.0804935012908274 1.0 0.5026350838666592 48 Q13501,O15460,P07737,Q9BVA1,Q92804,Q14738,P35637,P09651,Q9NR77,Q15165,P10644,Q8N0X7,Q14739 13 +Dysdiadochokinesis 0.5982826114285188 1.7451586087624136 0.0809572639248543 1.0 0.5026350838666592 13 O75503,Q6DKK2,Q13501 3 +Impaired temperature sensation 0.7978187387453352 1.744857700818249 0.081009641906717 1.0 0.5026350838666592 5 Q9NR77,P04792 2 +Hydrops fetalis 0.4761262461250868 1.744457675242577 0.0810793155374534 1.0 0.5026350838666592 35 P04062,P10619,P16278,P40939,Q13510,Q14739,Q99519 7 +Abnormal aortic valve physiology 0.4919750356147694 1.743651675722443 0.0812198465921507 1.0 0.5026350838666592 31 Q9NZ08,Q9UHX1,Q15056,O75844,P04062,P35250,Q9Y4P3,P16278 8 +Morphological abnormality of the pyramidal tract 0.5471265770995732 1.7433018820269823 0.0812808967971028 1.0 0.5026350838666592 19 Q9Y619,Q15056,P35250,P35637,O95831,Q13501 6 +Chondrosarcoma 0.9436964504283984 1.7407777687480728 0.0817225402611949 1.0 0.5026350838666592 3 P48735,O75874 2 +Cardiac arrest 0.5072315550732837 1.7366796514532123 0.0824437314330255 1.0 0.50365832061916 26 O15460,O43772,Q15056,P04062,P35250,Q9Y4P3,P04899 7 +Unusual infection by anatomical site 0.6662398048569169 1.7343248806981162 0.0828604552580281 1.0 0.5055059222155286 9 Q9NZ08,Q14739 2 +Abnormal epiphyseal ossification 0.5957415172963839 1.731003534488907 0.0834511340697534 1.0 0.5059397126164724 13 Q15738,Q9UG56,P10644,O00116,Q9UBM7,Q14739,Q99519 7 +Disproportionate short trunk short stature 0.8246058139530235 1.729781167504277 0.0836693803905259 1.0 0.5059397126164724 4 Q9UHX1 1 +Abnormal enchondral ossification 0.5332372973434806 1.7260216083117268 0.0843435253809332 1.0 0.5059397126164724 21 Q9Y619,Q15738,Q9UG56,O96028,P10644,O00116,Q9UBM7,Q14739,Q99519 9 +Pericardial effusion 0.7926354590465714 1.723352564618448 0.0848247874578913 1.0 0.5059397126164724 5 Q14108 1 +Abnormal renal tubule morphology 0.5748980294172703 1.721634113949198 0.0851358194040337 1.0 0.5059397126164724 15 O75306,Q15056,P06280,P23786,P35250 5 +Vertebral hypoplasia 0.6632016469716129 1.719617705401587 0.0855019556351164 1.0 0.5059397126164724 9 P16278 1 +Postural instability 0.5744224397759595 1.7188430925095566 0.0856429465597936 1.0 0.5059397126164724 15 O75503,P41440,Q9NR77,P04062 4 +Abnormality of the parathyroid gland 0.5742837966775846 1.7180293093881505 0.0857912693787823 1.0 0.5059397126164724 15 P21964,O75874,P00403,P40939,P48735,Q8WYQ5 6 +Abnormal social behavior 0.4245691465899513 1.716844264931917 0.0860076306951549 1.0 0.5063683793671286 51 O75306,Q9UHX1,Q15056,P05067,P35250,P18074,O43676,Q15067,Q5XKP0,O43681,Q9Y375 11 +Vertebral segmentation defect 0.5133539736973926 1.7148406526456974 0.0863744459301458 1.0 0.5073495011275367 24 Q9Y619,Q9UHX1,Q15056,O96028,P35250,Q9Y5S9,Q9Y4P3,Q9UM00 8 +Neoplasm of the adrenal cortex 0.8198371553338988 1.71035931461772 0.0871994496214472 1.0 0.5105310251040542 4 P48735 1 +Thickened skin 0.3962214995923642 1.704417988598646 0.0883030256084926 1.0 0.5137719479654954 80 Q15738,Q99519,P28070,P48449,Q06136,O95721,P06280,O75844,P04062,P07437,P18074,P31751,Q15555,P16278,Q9NWM8,P51648,O75431,Q14739 18 +Vascular skin abnormality 0.3807989792679574 1.7035050060992714 0.0884736019646863 1.0 0.5137719479654954 95 Q14108,Q99519,O75306,Q06136,Q13126,P06280,O75844,P04062,P18074,P10619,P16278,Q9NWM8,Q9Y487,Q9UBM7,Q14739 15 +Short middle phalanx of finger 0.9336414579204482 1.702157281536016 0.088725888321671 1.0 0.5137719479654954 3 Q9UHX1 1 +Stenosis of the external auditory canal 0.7647645086766282 1.6994762797133105 0.0892294801984281 1.0 0.5137719479654954 6 P55011,P16435,O96028,Q13363 4 +Tinnitus 0.6092692309799502 1.699201511132613 0.0892812217689904 1.0 0.5137719479654954 12 Q9NR28,Q02978,Q9NR77,O95831,Q969G3 5 +Joint subluxation 0.7863941263031555 1.6974093214322856 0.0896193014815076 1.0 0.5137719479654954 5 Q9UHX1 1 +Lateral clavicle hook 0.8621533442088027 1.6969745367844895 0.0897014746873567 1.0 0.5137719479654954 2 Q9Y619 1 +Fasting hyperinsulinemia 0.8156786329408277 1.693400764497751 0.0903792094723592 1.0 0.5137719479654954 4 Q16836 1 +Venous thrombosis 0.5886566718619539 1.6914307948647516 0.0907545549103914 1.0 0.5137719479654954 13 P48735,O75874 2 +Recurrent aspiration pneumonia 0.7628244785515246 1.6913039487165464 0.0907787662663128 1.0 0.5137719479654954 6 Q13510,P04062 2 +Hemivertebrae 0.656092197070032 1.6851214280058633 0.0919651462302353 1.0 0.5137719479654954 9 Q9UHX1 1 +Abnormal lung lobation 0.624631851313717 1.682323646193309 0.092506098271843 1.0 0.5137719479654954 11 Q9UHX1,Q14739 2 +Hypoplasia of the odontoid process 0.7824372977258243 1.6809353084906526 0.0927754807866656 1.0 0.5137719479654954 5 P16278 1 +Fluctuations in consciousness 0.8122031643020702 1.679212578758999 0.093110621341256 1.0 0.5144288961406541 4 O75306,P04062 2 +Abnormal retinal vascular morphology 0.4455610611615119 1.678946573198965 0.0931624566603355 1.0 0.5144288961406541 44 P17900,O75306,Q15056,P35250,P10619,Q15555,P16278,Q13510,Q8WYQ5,Q99519 10 +Generalized aminoaciduria 0.7817797202315162 1.678195548669509 0.0933089304643661 1.0 0.5145952611519845 5 Q16134 1 +Abnormal aortic valve morphology 0.4831327227834585 1.6759817927514442 0.0937417590074531 1.0 0.5150820360041678 31 Q9UHX1,Q15056,P61978,P06280,O75844,P04062,P35250,Q6NUK1,Q14738,Q9Y4P3 10 +Abnormal elasticity of skin 0.4162253576023132 1.674638414353554 0.0940051974495084 1.0 0.5150820360041678 52 Q9UHX1,Q15056,Q13126,O75844,P04062,P07437,P35250,Q15555,Q9Y4P3,Q9NWM8,Q9Y487,Q15904 12 +Progressive neurologic deterioration 0.5411550208774376 1.6721022426365406 0.0945041624862714 1.0 0.5150820360041678 18 P04062,P16278,Q5XKP0 3 +Frontotemporal dementia 0.6404305032452502 1.6718102325323452 0.0945617484140592 1.0 0.5150820360041678 10 P05067,P22626,P35637,P31483,Q13501 5 +Symptomatic seizures 0.6651050408590446 1.6668468617695726 0.0955448593421781 1.0 0.5197969408000664 8 P31751,Q16836,P40939 3 +Hepatic failure 0.4599373886942329 1.6639112791641637 0.0961301606526339 1.0 0.5210460662011247 38 Q9Y619,O15460,O43772,P04062,P23786,Q16836,P40939,Q96J02,O75648,Q13510,Q00059 11 +Cardiac valve calcification 0.8082541243796696 1.66307472641028 0.0962974782517098 1.0 0.5210460662011247 4 P04062,O75844 2 +Mitral valve calcification 0.8082541243796696 1.66307472641028 0.0962974782517098 1.0 0.5210460662011247 4 P04062,O75844 2 +Abnormality of the wrist 0.5292345735224124 1.662874347035724 0.0963375903879519 1.0 0.5210460662011247 20 Q13510,O75844,P16278 3 +Bifid tongue 0.8539967373572509 1.6621570656677105 0.0964812860544248 1.0 0.5210460662011247 2 Q9UBM7 1 +Oligosacchariduria 0.9228886168910676 1.6607707287475209 0.0967595020809732 1.0 0.5219113142733474 3 P10253,P16278 2 +Skin rash 0.5390078203305906 1.6585194840797253 0.0972126581575971 1.0 0.5231009425858365 18 P28070,Q06136,Q14739 3 +Hypoglycemic seizures 0.7082243398971892 1.65650960577024 0.0976186614077294 1.0 0.5231009425858365 7 P31751,Q16836,P40939 3 +Abnormal bleeding 0.3846392677373593 1.6559878724595662 0.0977242748104005 1.0 0.5231009425858365 88 Q14108,Q9NZ08,O15460,Q9UHX1,Q99519,Q86YV9,P05067,Q6ZXV5,Q13126,O75844,P04062,P11117,P23786,Q02978,Q9NWM8,Q9Y487,Q14739 17 +Focal t2 hyperintense brainstem lesion 0.5635338475842534 1.6547279766087493 0.097979689426886 1.0 0.5233866743177743 15 Q8IUX1,O75306,Q8N183,O43676,Q9P032,Q9Y375 6 +Diffuse cerebral atrophy 0.6492603364962983 1.651867383828353 0.0985615883592219 1.0 0.524146581504769 9 P16278 1 +Flared iliac wing 0.8053309355759568 1.6511180595852188 0.0987144703580087 1.0 0.524146581504769 4 P16278 1 +Edema of the dorsum of feet 0.8503262642740619 1.6464736565608604 0.099666279395739 1.0 0.5247904211516442 2 Q9Y5S9 1 +Edema of the dorsum of hands 0.8503262642740619 1.6464736565608604 0.099666279395739 1.0 0.5247904211516442 2 Q9Y5S9 1 +Contractures of the large joints 0.8503262642740617 1.646473656560859 0.0996662793957392 1.0 0.5247904211516442 2 O75431 1 +Impaired oropharyngeal swallow response 0.850326264274055 1.6464736565608302 0.0996662793957452 1.0 0.5247904211516442 2 Q9NR77 1 +Abnormality of the gingiva 0.4550928821038339 1.6426912314726376 0.100446833920732 1.0 0.5276441169018977 39 Q14108,Q15056,Q9UBM7,P04062,P35250,P16278,Q15392,Q14739,Q99519 9 +Mesomelia 0.7708827330143422 1.6327139821862793 0.1025291653377835 1.0 0.5316371609484368 5 Q14739 1 +Optic neuropathy 0.5390553136342267 1.6281075996607977 0.1035020724051358 1.0 0.5339511983009357 17 Q8IUX1,O75306,Q8N183,O43676,Q9P032,Q9Y375 6 +Spastic paraparesis 0.533990426081091 1.6267091230062032 0.1037988902440796 1.0 0.5339511983009357 18 P04062,Q6DKK2,Q5XKP0 3 +Abnormal sternal ossification 0.7992530723019726 1.626228811592005 0.1039009892190336 1.0 0.5339511983009357 4 Q9Y619,O96028 2 +Limb ataxia 0.5284949911051698 1.6237737786780415 0.1044240982433437 1.0 0.5339511983009357 19 Q14108,Q8IV08,P04062,Q9NR77,Q13501 5 +Mitral stenosis 0.798341189794654 1.6224912827721778 0.1046981981157912 1.0 0.534200045988378 4 O75844 1 +Coarse facial features 0.4023280011999 1.6212788980861317 0.1049578385264822 1.0 0.534825483643584 55 Q9Y2Q5,P06280,P35250,P16278,P15586,Q969G3,Q99519,P38159,P18074,Q92785,P10619,O95831,Q15056,P61978,Q9UQR1,Q9Y263,P54802,Q9Y4P3,Q06787,Q13642 20 +Supernumerary bones of the axial skeleton 0.7674920994266082 1.6185323406226362 0.1055479229545217 1.0 0.5359798659332373 5 Q9Y5S9,Q9UHX1 2 +Preaxial hand polydactyly 0.7672100371688867 1.6173519675679968 0.1058023276147399 1.0 0.5366556135779758 5 Q9UHX1 1 +Shuffling gait 0.6542465386398143 1.6151123362724105 0.1062863699299276 1.0 0.5384932579611341 8 O75844 1 +Abnormality of prothrombin 0.611288750124913 1.6131014806672814 0.106722462242278 1.0 0.5394668005686807 11 Q16836,Q5XKP0 2 +Diffuse white matter abnormalities 0.910375212561898 1.6125067856502064 0.1068517045223262 1.0 0.5395035263724305 3 P16278 1 +Wormian bones 0.5744130530921231 1.611406745066562 0.1070910980539356 1.0 0.5399162338519856 13 O75718,O75844,O95831,Q9Y487 4 +Long toe 0.6976866595788707 1.6092222578813535 0.1075677511428705 1.0 0.5403592280280763 7 Q15738,Q9UHX1,P23786 3 +Macular degeneration 0.5915220582592192 1.6034923502240324 0.1088259966929945 1.0 0.5451595730760888 12 Q13510,P50897,P04062 3 +Sensory axonal neuropathy 0.5728619267974555 1.6026555054641576 0.1090107320439131 1.0 0.5451595730760888 13 O95140,Q8IV08,P22626,O95831,Q15067 5 +Abnormal mitral valve physiology 0.4800792215303213 1.6023365072881317 0.1090812168601262 1.0 0.5451595730760888 29 Q9NZ08,O75306,Q15056,P06280,O75844,P04062,P35250,Q9Y4P3,P40939,O75431 10 +Abnormalities of placenta or umbilical cord 0.5910076413584056 1.600705382824947 0.109442188379955 1.0 0.5462772908827731 12 P16278 1 +Aplasia hypoplasia of the femur 0.6074807453568691 1.5932655471424455 0.1111006321888772 1.0 0.5490481521468201 11 Q9UHX1 1 +Abnormal endocardium morphology 0.5709398705284001 1.59180176207847 0.111429254116391 1.0 0.5495922139187167 13 Q9NZ08,Q15056,P06280,P04062,P35250 5 +Thoracic scoliosis 0.6239916301737788 1.5895367581628346 0.1119392621070649 1.0 0.551344494765644 10 Q9UHX1 1 +Hypomimic face 0.6928038064090364 1.587249450260277 0.1124561590247981 1.0 0.5522840015639933 7 Q9Y263,P04062,P35270 3 +Enchondroma 0.6472880878646778 1.581838084560656 0.1136865383497613 1.0 0.5531281777533914 8 P48735 1 +Abnormal oral mucosa morphology 0.4145139732926465 1.5796635227136442 0.1141839434895557 1.0 0.5531281777533914 50 Q14108,Q9NZ08,Q15056,Q9UBM7,P04062,P35250,P16278,Q15392,Q14739,Q99519 10 +Congenital craniofacial dysostosis 0.8344208809135426 1.5784152248077954 0.1144702498132255 1.0 0.5531281777533914 2 Q6NUK1 1 +Aplasia hypoplasia of the nasal bone 0.8344208809135426 1.5784152248077954 0.1144702498132255 1.0 0.5531281777533914 2 Q6NUK1 1 +Bacterial endocarditis 0.8344208809135304 1.578415224807743 0.1144702498132375 1.0 0.5531281777533914 2 P04062 1 +Bilateral tonic clonic seizure with generalized onset 0.6906613604469973 1.5775965759570336 0.1146583195090138 1.0 0.5531281777533914 7 Q13510 1 +Abnormal blood glucose concentration 0.3882532914142672 1.5773065877099353 0.1147249973248185 1.0 0.5531281777533914 76 P31751,Q13423,P40939,O75880,Q9Y375,O75306,O43772,Q16134,P23786,Q9BZH6,P13804,O75844,Q16836,P16219,O43676,Q00059,P22695,Q14738,Q5XKP0,Q9H0R6,Q9P032,Q8N183 22 +Pulmonary infiltrates 0.6904895808101011 1.5768223063619775 0.1148364175161831 1.0 0.5531281777533914 7 Q9NZ08,Q13510 2 +Asymmetric septal hypertrophy 0.8340130505709626 1.576668302911767 0.1148718674284134 1.0 0.5531281777533914 2 P54802 1 +Infectious encephalitis 0.7355587525738323 1.5758834667743569 0.1150526618885643 1.0 0.5531281777533914 6 Q14739 1 +Talipes calcaneovalgus 0.7867362785185827 1.574854323482976 0.115290073908878 1.0 0.5531739091488879 4 Q9UBM7 1 +Velopharyngeal insufficiency 0.7865946783009279 1.5742722736890586 0.1154245168498366 1.0 0.5531739091488879 4 Q9BUF5 1 +Thoracic kyphosis 0.5675217013989294 1.572473096399904 0.1158408737481808 1.0 0.5537709053157566 13 Q9UHX1,P04062,O95831 3 +Bradycardia 0.6887329334764496 1.5689018770769263 0.1166708044453883 1.0 0.5558560418111068 7 O43772,O75880,O43464 3 +Aortic valve calcification 0.898333431875202 1.565971418348841 0.1173553085208176 1.0 0.5558560418111068 3 O75844 1 +Abnormal corneal epithelium morphology 0.5389257691748222 1.56514472618067 0.1175489783985588 1.0 0.5558560418111068 16 Q9NZ08,O75844,Q14739,P18074 4 +Abnormal astrocyte morphology 0.5843869032403034 1.5647739793452915 0.1176359150068735 1.0 0.5558560418111068 12 P48735,O75874,O95831,Q13501 4 +Premature rupture of membranes 0.753884308556445 1.5614817423298086 0.1184101283720164 1.0 0.5558560418111068 5 O75844 1 +Abnormality of fontanelles 0.4515194646947717 1.558935880005996 0.1190115570589269 1.0 0.5576145305843581 36 Q9Y619,P13804,Q16134,O75718,O75844,Q14738,P20674,Q9Y487 8 +Gastrointestinal hemorrhage 0.4798697939203869 1.5576683159392095 0.1193118949993303 1.0 0.5579877720771679 27 Q9UHX1,Q14739 2 +Decreased activity of mitochondrial complex i 0.4796960574636516 1.5563855148810146 0.1196164475431882 1.0 0.5580839108475966 27 Q8IUX1,O75306,Q8N183,O43676,O75648,Q9H0R6,Q9P032,Q9UBX3,Q9Y375,Q70HW3 10 +Airway obstruction 0.5643209480893794 1.554343522554121 0.1201024971750945 1.0 0.5597611643892975 13 O75844,P09601 2 +Visual loss 0.4395955075036211 1.5512828171446504 0.1208339227866883 1.0 0.5601490028861033 41 O75306,P48449,O15460,P50897,P40939,O75503,Q99519 7 +Abnormal cellular phenotype 0.3840243779123731 1.5497508389440633 0.1212013306916321 1.0 0.5601490028861033 150 P28070,P21964,Q9Y2Q5,P40939,P09601,O75880,P15586,Q15904,Q9Y375,Q13501,Q14739,O75306,O43772,Q16134,P23786,Q969G3,O75503,Q13510,Q8WYQ5,Q14108,P13804,O75844,P18074,P00403,Q16836,P20674,Q9Y5S9,O43676,Q96J02,Q70HW3,P04062,P35637,P17812,O75648,Q9H0R6,Q9P032,Q9UBX3,Q8N183 38 +Glomerulopathy 0.6283933207688865 1.5496892329155705 0.1212161236648226 1.0 0.5601490028861033 9 Q9NZ08,Q14108 2 +Osteopetrosis 0.8274877650897143 1.5487070525135749 0.1214521577589349 1.0 0.5601490028861033 2 Q15392 1 +Aplastic clavicle 0.8274877650897134 1.5487070525135709 0.1214521577589358 1.0 0.5601490028861033 2 Q9Y619 1 +Coma 0.4728914542162918 1.54802928180967 0.1216152467027353 1.0 0.5603169126731236 29 Q9Y619,O43772,P05067,Q16134,P23786,Q16836,P40939 7 +Decreased calvarial ossification 0.7791032633979109 1.543452916080892 0.1227209230883228 1.0 0.5630649821780621 4 O75844 1 +Severe lactic acidosis 0.8920873222046485 1.5418029573072871 0.1231214832249896 1.0 0.5637445016954794 3 Q70HW3 1 +Pleural effusion 0.6259443453093386 1.537640101082976 0.124136636767471 1.0 0.5671130083022635 9 Q14739 1 +Osteolytic defects of the distal phalanges of the hand 0.7774865684339162 1.5367954668061288 0.1243434038915323 1.0 0.5671130083022635 4 O75844 1 +Gingival overgrowth 0.4875828100461081 1.533596870287809 0.1251288587538035 1.0 0.5688026128140524 24 Q13155,Q99519,Q15056,P35250,Q9Y4P3,P16278,Q9UM00,Q9UBM7,Q14739 9 +Coxa valga 0.5780307493853964 1.53017231318191 0.1259740826299031 1.0 0.5709849693789367 12 O75844,P16278 2 +Unilateral renal agenesis 0.523266361539915 1.5289439729464511 0.1262783338707078 1.0 0.5709849693789367 17 Q9UBM7,Q9UHX1 2 +Renal tubular dysfunction 0.4759473383255032 1.528669199831338 0.1263464714975162 1.0 0.5709849693789367 27 Q8IUX1,O75306,P13804,Q8N183,Q4G0N4,Q16134,P00403,O43676,Q9P032,Q9Y375 10 +Cutaneous photosensitivity 0.5085650671018145 1.5269117561827494 0.1267829558410673 1.0 0.5720401695161347 20 Q14108,Q9UBM7,Q06136 3 +Sensorimotor neuropathy 0.4865882391775913 1.5265387733287947 0.1268757418709762 1.0 0.5720401695161347 24 P41440,Q9NR77,O95831,P40939,Q15120 5 +Abnormality of facial soft tissue 0.3717954508693544 1.524237739376083 0.1274493337431415 1.0 0.5729982286122594 90 Q99519,Q9BUF5,Q9UHX1,P28070,Q15056,P10253,O75844,P04062,P35270,P35250,Q14738,Q8NFH4,P16219,Q9Y4P3,Q969G3,Q13510,Q9UBM7,Q13501 18 +Abnormal femoral neck head morphology 0.4598958107746956 1.5221683957710352 0.1279668918627889 1.0 0.5735337263057698 32 Q9Y619,O75844,O95831,P16278,Q9Y487,Q14739 6 +Organic aciduria 0.4563148867321882 1.5216441682511974 0.1280982641375565 1.0 0.5735337263057698 33 O43772,Q96EY8,P13804,Q4G0N4,Q16134,Q8NFF5,P23786,Q9HC21,Q16836,P16219,P40939,O75880,P48735 13 +Capillary malformation 0.593421454818885 1.5197343306197029 0.1285777596128081 1.0 0.5739149122139626 11 P35250,Q9UHX1,Q9Y4P3,Q15056 4 +Abnormal lung development 0.4485744859269091 1.5197324292196102 0.1285782376840003 1.0 0.5739149122139626 35 Q9UHX1,P13804,Q16134,O75844,O96028,Q6NUK1,Q9UBM7,Q8WYQ5,Q14739 9 +Abnormal aortic arch morphology 0.67782661960357 1.5196231130489697 0.12860572549625 1.0 0.5739149122139626 7 Q9UHX1 1 +Abnormal heart valve physiology 0.3897766949379414 1.519173312455673 0.1287188769876217 1.0 0.5739149122139626 64 Q9NZ08,O75306,Q9UHX1,Q15056,P06280,O75844,P04062,P35250,Q6NUK1,Q9Y4P3,P40939,P16278,Q15904 13 +Mild postnatal growth retardation 0.8197389885807503 1.5154807161826676 0.1296507101978452 1.0 0.5765813426710206 2 P10644 1 +Hand polydactyly 0.4963018497547059 1.5153068382820534 0.1296947173791132 1.0 0.5765813426710206 22 Q9UHX1,O96028,Q9Y263,Q9UM00,Q15067,Q9BW83,Q9UBM7,Q14739 8 +Kyphosis 0.3635111662783422 1.5152544088860094 0.1297079891380659 1.0 0.5765813426710206 115 Q9UHX1,P35250,P07237,Q9NR77,P16278,Q9Y375,Q14739,Q9NWM8,Q8N0X7,Q99519,Q14108,Q15738,O75844,O96019,P18074,O95831,Q9UBM7,Q9Y487,Q15056,O95140,P51648,P04062,O96028,Q9Y263,Q9Y4P3,O75648,Q13642,Q9P032 28 +Ureteral duplication 0.7717833358718053 1.513292625256694 0.1302053451372475 1.0 0.5782110858855884 4 O75844 1 +Breech presentation 0.6755729681282445 1.5094186621407526 0.1311918268941192 1.0 0.5814681997836025 7 Q9Y619,Q9UBM7 2 +Abnormal aortic valve cusp morphology 0.5108651678427965 1.5093798765997224 0.1312017326213057 1.0 0.5814681997836025 19 Q9UHX1,Q15056,Q14738,Q6NUK1,P35250,Q9Y4P3 6 +Angina pectoris 0.8825933309370947 1.5050332971966869 0.1323155163600371 1.0 0.5839034709560479 3 O75844 1 +Acidemia 0.590464587055524 1.5042124073817456 0.1325266840614283 1.0 0.5839034709560479 11 P48735,Q16134 2 +Orthostatic hypotension 0.5903607941097053 1.5036672017790822 0.1326670782601648 1.0 0.5839034709560479 11 P04062 1 +Parkinsonism with favorable response to dopaminergic medication 0.6308949243151484 1.503094792811605 0.1328146014181959 1.0 0.5839034709560479 8 P04062,P31930 2 +Abnormal urine ph 0.4502341875525094 1.5020799394357744 0.1330764650106373 1.0 0.5839034709560479 34 O43772,Q96EY8,P13804,Q4G0N4,Q16134,Q8NFF5,P23786,Q9HC21,Q16836,P16219,P40939,O75880,P48735 13 +Abnormal atrioventricular conduction 0.6063313998793238 1.5004972965158214 0.1334856332782492 1.0 0.5839034709560479 10 O43772 1 +Increased serum pyruvate 0.4693899334169342 1.4999069709349375 0.1336385020207744 1.0 0.5839034709560479 28 Q8IUX1,O75306,Q8N183,P22695,O95831,O43676,Q5JRX3,Q9P032,Q9Y375,Q70HW3 10 +Malrotation of small bowel 0.7682118799314419 1.498561640955657 0.1339873902424213 1.0 0.5839034709560479 4 O96028,Q13363 2 +Hemiparesis 0.5543508448107319 1.497688287678551 0.1342142562632804 1.0 0.5839034709560479 13 Q9NZ08,P00403,Q9BVA1 3 +Urinary glycosaminoglycan excretion 0.7386688444262863 1.4974553154027674 0.1342748243091553 1.0 0.5839034709560479 5 P15586,P54802,P16278,P08236 4 +Eeg with generalized slow activity 0.6727961122313315 1.4968353599137043 0.1344361030648762 1.0 0.5839034709560479 7 O75503 1 +Bulbar palsy 0.6054304780928654 1.4959379460214235 0.1346698266963693 1.0 0.5839034709560479 10 P35637,P31483,O43681,Q13501 4 +Late onset 0.6165681167550173 1.491403459824168 0.1358556003070636 1.0 0.5859277156008176 9 P31751,P31483,P31930 3 +Abnormal iliac wing morphology 0.6715861131418925 1.4913489275570482 0.1358699094651181 1.0 0.5859277156008176 7 P16278 1 +Neurofibrillary tangles 0.7661728200107859 1.490146928585789 0.1361856072211584 1.0 0.5859277156008176 4 P61916,P05067 2 +Drowsiness 0.7657681078774811 1.4884764156111847 0.1366252973337967 1.0 0.5859277156008176 4 P35270 1 +Sensory ataxia 0.7656575859432219 1.488020198311173 0.1367455669924833 1.0 0.5859277156008176 4 P54802,Q9NR77 2 +Nephrotic syndrome 0.497562912787411 1.4876927750518945 0.136831933840192 1.0 0.5859277156008176 21 Q14108,O95721,Q8NCH0,Q9BW83,P06280,P51809,Q07021,P57081 8 +Abnormality of the pancreas 0.3893666851010286 1.4874227437833891 0.1369031936412794 1.0 0.5859277156008176 56 Q9NZ08,Q9UHX1,Q01844,P09601,Q15904,Q14739 6 +Decreased light and dark adapted electroretinogram amplitude 0.8780459918980451 1.4874091578395454 0.1369067796552081 1.0 0.5859277156008176 3 P50897 1 +Echolalia 0.6157058339976398 1.4871431880954007 0.1369769970452736 1.0 0.5859277156008176 9 Q9UHX1 1 +Abnormality of the peripheral nervous system 0.3798926530092585 1.481391078712881 0.1385023906541094 1.0 0.5875430903700074 76 Q9Y619,P41440,P04792,O95721,P31930,P06280,Q9UBM7,P04062,Q9NR77,O95831,Q15067,Q15120,Q99720,O43681,Q99519 15 +Supernumerary tooth 0.734460626354141 1.4797074508567876 0.1389513363373691 1.0 0.5875430903700074 5 Q9UHX1 1 +Abnormal mitochondria in muscle tissue 0.5106079110186013 1.4771913463752575 0.1396243528006118 1.0 0.5875430903700074 18 Q8IUX1,O75306,Q8N183,P00403,O43676,Q9P032,Q9Y375 7 +External ear malformation 0.612830767039544 1.472928779786907 0.1407702408289961 1.0 0.5890851552542273 9 Q8NCH0,Q15555,Q00577,P07437 4 +Hepatosplenomegaly 0.4568078493460107 1.471844335295284 0.141062918165834 1.0 0.5890851552542273 31 P04062,P10619,P16278,Q13510,Q14739 5 +Intellectual disability progressive 0.5842659287449705 1.4716111650514592 0.1411259088100993 1.0 0.5890851552542273 11 P18074,O95831,O95721 3 +Calcinosis 0.7320036110057212 1.469337804316019 0.1417411878008267 1.0 0.5890851552542273 5 Q14739 1 +Abnormality of the hallux 0.4277232415706632 1.4686099395519794 0.1419386173528241 1.0 0.5890851552542273 42 Q9UHX1,P04792,Q15056,O95140,O96028,Q13363,P04062,P35250,O96019,Q9Y4P3,P10644,O75648,Q13642,Q9Y3E5,Q96J02 15 +Abnormality of peripheral nerves 0.4405919733981892 1.4678827782776798 0.1421360669358367 1.0 0.5890851552542273 36 Q9Y619,P04792,O95721,P31930,Q9NR77,O95831,Q15120,Q99720,O43681 9 +Nausea and vomiting 0.3622438233178878 1.4676668955988894 0.1421947271825874 1.0 0.5890851552542273 119 Q9Y619,P06280,Q92804,P35250,Q01844,P40939,Q9Y375,Q13501,P42892,O75306,P07737,Q16134,P23786,O43464,Q02978,Q15165,P13804,P00403,Q16836,O43676,Q9UBM7,Q9NZ08,Q15056,P22695,P11117,P35637,Q9Y4P3,O75648 28 +Wide cranial sutures 0.6662740025701643 1.467239201259 0.1423109963849902 1.0 0.5890851552542273 7 O75844 1 +Abnormal circulating dicarboxylic acid concentration 0.4386508129237331 1.4669977242631524 0.1423766744216072 1.0 0.5890851552542273 37 P41440,P13804,Q16134,P22695,P23786,P48735,Q14739 7 +Brachydactyly 0.4098423226443506 1.465656950425989 0.1427417677518025 1.0 0.5894928466538027 48 P48449,Q9UHX1,Q06136,O95831,Q14739 5 +Hyperconvex nail 0.6226044653911003 1.463094978936896 0.1434413916003392 1.0 0.5907403924836689 8 Q9Y619,O96028,P48651,P42892 4 +Abnormality of hepatobiliary system physiology 0.3852805583027279 1.4619301554745123 0.1437603504278879 1.0 0.5907403924836689 62 Q9Y619,O75306,O43772,O15460,Q9H0R6,P22695,P04062,P23786,Q16836,P40939,Q5XKP0,Q96J02,O75648,Q13510,Q00059 15 +Aplasia hypoplasia of the ribs 0.5310519591428869 1.4611336039576464 0.1439787798094947 1.0 0.5907403924836689 15 Q03164,Q9UHX1,Q14739 3 +Cholestatic liver disease 0.7589955672359794 1.4605046558552237 0.1441514288982994 1.0 0.5909006209612405 4 Q9UBM7 1 +Metatarsus adductus 0.6092565542869927 1.4552375745886 0.1456035019463213 1.0 0.5940998977016413 9 Q9UBM7,Q15392,O96028,Q13363 4 +Abnormal femoral neck morphology 0.4700077010305569 1.449534953121261 0.1471882464478593 1.0 0.5963166840986538 25 Q9Y619,O75718,O75844,Q9Y5S9,P16278,O95831,Q9Y487 7 +Abnormal pulmonary interstitial morphology 0.4673353107710682 1.4466165695649096 0.1480043428572266 1.0 0.5963166840986538 26 Q14108,Q13510,P09601 3 +Increased susceptibility to fractures 0.4226533139459109 1.4463256819580137 0.1480858757274321 1.0 0.5963166840986538 43 Q14108,Q13126,O75718,O75874,P04062,P22626,P48735,Q14739,Q13501 9 +Abnormal brainstem mri signal intensity 0.5055977933503293 1.4448949162266702 0.1484874045139677 1.0 0.596512070994804 18 Q8IUX1,O75306,Q8N183,O95831,O43676,Q9P032,Q9Y375 7 +Broad palm 0.7248358831058033 1.439057707124319 0.1501341734163963 1.0 0.6002338659971069 5 Q13642,O95831,Q14739 3 +Increased connective tissue 0.6598922573363969 1.4382264623634142 0.1503698092283518 1.0 0.6002338659971069 7 P31751,O95831 2 +Multiple prenatal fractures 0.7245854708907499 1.4379990869092705 0.1504343132199765 1.0 0.6002338659971069 5 Q14739 1 +Neck flexor weakness 0.8646864403732301 1.4355949817431994 0.1511176235269209 1.0 0.6002338659971069 3 P35637 1 +Neoplasm of the adrenal gland 0.5934630150803653 1.4352263422770004 0.1512226094084083 1.0 0.6002338659971069 10 P48735 1 +Stillbirth 0.5934157972169031 1.4349862790741756 0.1512910075614675 1.0 0.6002338659971069 10 O75844,Q14739 2 +Multiple enchondromatosis 0.7236065350746623 1.4338601576968424 0.1516121736234947 1.0 0.6002338659971069 5 P48735 1 +Aplasia hypoplasia of the lungs 0.4734753288582475 1.4330640233055116 0.151839541634287 1.0 0.6002338659971069 24 P13804,Q16134,O75844,O96028,Q6NUK1,Q9UBM7,Q14739 7 +Hypotension 0.4942735090457105 1.4319075425148071 0.1521702833707821 1.0 0.6002338659971069 20 O43772,P04062 2 +Dystrophic toenail 0.7518941210131418 1.4311425475242336 0.1523893653471777 1.0 0.6002338659971069 4 O75844 1 +Slurred speech 0.6581166546034916 1.4301452227184843 0.1526753431592729 1.0 0.6002338659971069 7 Q9Y487,P16278,Q99519 3 +Areflexia 0.3819880848809667 1.4298807707394208 0.1527512418736722 1.0 0.6002338659971069 63 O43505,P41440,O75340,P04792,O95140,O95721,P61978,Q15041,Q14738,Q9NR77,O60701,P40939,O95831,Q15120,Q15067,Q13510,P10253,Q13501 18 +Abnormal systemic arterial morphology 0.357683743180188 1.4297341371485317 0.1527933386374043 1.0 0.6002338659971069 116 Q9UHX1,P35250,Q6NUK1,P16278,Q6ZXV5,P05067,Q9NWM8,Q13510,Q8WYQ5,Q99519,P61916,O75844,O96019,P18074,P10619,Q9Y5S9,Q9UBM7,P17900,O15460,Q15056,O15118,P04062,Q9Y4P3,O75648,P10253 25 +Ascites 0.4730037268534995 1.429688154551496 0.152806541513168 1.0 0.6002338659971069 24 Q14108,P04062,Q01844,Q13510,Q14739,Q99519 6 +Abnormal thoracic spine morphology 0.4829296540844907 1.423256151234139 0.1546619132576119 1.0 0.6041831966848639 22 P04062,Q9UHX1,O75844,O95831 4 +Abnormality of the odontoid process 0.6994230250316283 1.4214818525067434 0.1551767256427088 1.0 0.6041831966848639 6 P16278 1 +Ectopic kidney 0.574561916565952 1.4204132747985527 0.155487400380303 1.0 0.6041831966848639 11 P35250,Q9UHX1,Q15056 3 +Paroxysmal involuntary eye movements 0.5153775143803077 1.4201690751731957 0.1555584644007024 1.0 0.6041831966848639 16 Q8IUX1,O75306,Q8N183,O43676,Q9P032,Q9Y375 6 +Pituitary adenoma 0.5744298363743103 1.4197151297872876 0.1556906315976127 1.0 0.6041831966848639 11 P48735 1 +Chorioretinal degeneration 0.7197249215119935 1.4174415980337025 0.1563538579366521 1.0 0.6041831966848639 5 Q9Y619 1 +Lipid accumulation in hepatocytes 0.3820330011073774 1.416823119981017 0.1565346483292771 1.0 0.6041831966848639 59 O75431,O43772,P13804,Q16134,P23786,P22626,P31751,P09651,Q16836,P16219,P40939,Q15067,Q5XKP0,O75648,Q00059,Q15904,Q9Y375 17 +Abnormal sensory nerve conduction velocity 0.7482001688117873 1.4158577319055572 0.1568171625128247 1.0 0.6041831966848639 4 Q9NR77,O95140 2 +Chronic pulmonary obstruction 0.697151987439549 1.4117323981030534 0.15802877008639 1.0 0.6072643354405762 6 P09601 1 +Cardiomegaly 0.445911476654386 1.4111748592237243 0.1581930612475899 1.0 0.6073679773420921 32 Q15056,P04062,P23786,P35250,P20674,P10253,Q14739,Q99519 8 +Severe short stature 0.4861965052952677 1.4106546049047624 0.1583464823179072 1.0 0.6074297409298385 21 Q9Y619,P10619,P16278 3 +Ankylosis 0.7177941578382795 1.4092707061122531 0.1587551373623033 1.0 0.607521561044646 5 P48651,P16435,O75844 3 +Loss of subcutaneous adipose tissue in limbs 0.7463339355464003 1.4081329016557609 0.1590917201293762 1.0 0.607521561044646 4 O75844 1 +Nasogastric tube feeding in infancy 0.6524365683554914 1.4042686534767357 0.1602388649435167 1.0 0.6088801543343422 7 O75648,Q9UHX1 2 +Sea blue histiocytosis 0.8563851489188141 1.403379693494483 0.1605036450631811 1.0 0.6093627657634766 3 P61916,P16278 2 +Abnormal urine protein level 0.3929940351204494 1.4015462022014673 0.1610508015598324 1.0 0.6103921981997762 51 Q14108,Q15056,O95721,P06280,Q8NFH4,P04062,P35250,Q02978,P00403,Q9Y4P3,P09601,Q99519 12 +Cranial asymmetry 0.7444639760932623 1.400390911936131 0.1613962899899568 1.0 0.6111779029328587 4 O96028 1 +Abnormal nerve conduction velocity 0.4410993885370731 1.3991320168868653 0.1617733982477796 1.0 0.611558752521307 33 Q9Y619,P04792,P31930,Q9NR77,O95831,Q15120,Q99720,O43681 8 +Positional foot deformity 0.3770872673795595 1.3982752081409968 0.1620304397362124 1.0 0.6120073739993747 68 Q9Y619,Q9UHX1,P04792,P21964,Q8NCH0,P16435,P08236,Q03001,Q6NUQ1,Q9NR77,Q15392,Q6ZXV5,Q9NWM8,Q9Y3E5,Q8WYQ5,Q13363,Q9HC21,P18074,Q9Y5S9,Q9UM00,Q9UBM7,P61978,Q9UQR1,O96028,Q9Y487,Q96AY3 26 +Arthralgia 0.452967030911179 1.3960853538677025 0.1626887937144383 1.0 0.6124456942360339 29 Q9NZ08,P28070,O15460,Q15056,P06280,P35250,P18074,Q13510 8 +Mitochondrial myopathy 0.4789303208236443 1.3955872368968985 0.1628388280401482 1.0 0.6124456942360339 22 Q8IUX1,O75306,Q8N183,P00403,Q9P032,O43676,P12235,Q9Y375 8 +Abnormal urine carbohydrate level 0.5967172441713726 1.3930042090423875 0.1636185178844382 1.0 0.6141814170243065 9 P10253,P16278 2 +Ectopic calcification 0.4054461347939322 1.3926789081303208 0.1637169094894093 1.0 0.6141814170243065 47 O00584,P05067,O75844,P04062,P23786,P18074,Q9UBM7,Q14739,Q99519 9 +Global brain atrophy 0.500697076719921 1.3856734488095783 0.1658466391873869 1.0 0.6189140583094743 17 P35637,Q9UHX1,Q13501 3 +Chorioretinal atrophy 0.7406702107447338 1.3846790090687258 0.1661506403715447 1.0 0.6189140583094743 4 Q9Y619 1 +Dermatological manifestations of systemic disorders 0.3796220885363349 1.381823608604519 0.167025868215785 1.0 0.6195272116583923 55 P61916,O43772,P13804,Q16134,O75844,P00374,Q15904,Q14739 8 +Periventricular leukomalacia 0.534035033256751 1.3814413766971736 0.1671432911209764 1.0 0.6195272116583923 13 P18074,Q9UHX1 2 +Aplasia hypoplasia involving bones of the thorax 0.4662535064130872 1.3812654293653654 0.1671973635667403 1.0 0.6195272116583923 24 Q03164,Q9UHX1,O75844,Q14739 4 +Renal hypoplasia 0.4710215209599609 1.3767932317278588 0.1685761840078843 1.0 0.6195272116583923 23 Q9UBM7,Q9UHX1,Q15056,P35250 4 +Abnormality of the skull base 0.41495477694945 1.3763446932357724 0.168714942104164 1.0 0.6195272116583923 43 Q9UHX1,P07437,Q9Y487,Q9UBM7,Q14739 5 +Lambdoidal craniosynostosis 0.7871125611745544 1.3754549112075267 0.1689904551730903 1.0 0.6195272116583923 2 P61978 1 +Elbow ankylosis 0.7871125611745527 1.375454911207521 0.168990455173092 1.0 0.6195272116583923 2 P48651 1 +Humeroradial synostosis 0.7871125611745527 1.375454911207521 0.168990455173092 1.0 0.6195272116583923 2 P48651 1 +Facial hemangioma 0.7871125611745374 1.375454911207455 0.1689904551731125 1.0 0.6195272116583923 2 Q9UBM7 1 +Facial capillary hemangioma 0.7871125611745374 1.375454911207455 0.1689904551731125 1.0 0.6195272116583923 2 Q9UBM7 1 +Abnormal circulating cholesterol concentration 0.4654074118845045 1.375182700841483 0.1690748100743015 1.0 0.6195272116583923 24 Q15738,P61916,Q9UBM7,Q15392,Q15904,O75431,Q14739 7 +Aplasia hypoplasia of the tongue 0.7383763184337159 1.375175843160663 0.1690769355995423 1.0 0.6195272116583923 4 P48651,Q9UBM7 2 +Microglossia 0.7383763184337159 1.375175843160663 0.1690769355995423 1.0 0.6195272116583923 4 P48651,Q9UBM7 2 +Heparan sulfate excretion in urine 0.7383673469387733 1.375138671788986 0.1690884571449062 1.0 0.6195272116583923 4 P15586,P54802,P08236 3 +Megalocornea 0.5815609484074422 1.3745927385490244 0.169257741098191 1.0 0.6195272116583923 10 Q96EK5,Q15056,O96028,P35250 4 +Abnormal bone structure 0.36781059166315 1.374287038863221 0.1693525885042408 1.0 0.6195272116583923 143 Q9Y619,P06280,Q86XL3,P35250,P07237,P16278,P48735,Q15392,Q9Y375,Q14739,Q13501,O75874,Q9NWM8,Q13510,Q99519,Q14108,Q13126,O75718,O75844,P18074,O95831,Q9UBM7,Q15056,Q9UG56,P04062,O96028,P51809,P22626,Q9Y4P3,Q9Y487 30 +Abnormal visual fixation 0.7367923909976535 1.368612717182955 0.1711203666508742 1.0 0.6204810259392063 4 Q13510 1 +Abnormal autonomic nervous system physiology 0.4589202018636142 1.3685244845609106 0.1711479633287613 1.0 0.6204810259392063 25 P41440,P06280,P04062,Q15067,O43681,P42892 6 +Phenotypic variability 0.3694771968343317 1.368189075114908 0.1712529003660436 1.0 0.6204810259392063 77 P17900,Q9BUF5,Q9BVA1,P35270,P00374,Q9NR77,P00403,Q9H061,Q92733,O14979,Q13510,Q9Y375 12 +Abnormality of blood circulation 0.3769411176588146 1.36762847034635 0.1714284001125277 1.0 0.6204810259392063 61 Q9NZ08,Q9UHX1,P05067,O75844,P04062,Q9Y487,Q14739 7 +Meningitis 0.7075824262799043 1.3660142116251786 0.1719345027991268 1.0 0.6210938036790739 5 Q9NZ08 1 +Abnormal cardiac test 0.5312644832622587 1.3655115349138702 0.1720923301604622 1.0 0.6210938036790739 13 Q16836,P10253,P40939 3 +Abnormal retinal morphology 0.3770941729344212 1.360961359381889 0.1735259009581895 1.0 0.6221956734508463 167 Q9Y619,Q9UHX1,P35250,P50897,P16278,P40939,Q9Y375,O75306,P07437,O75503,Q13510,Q8WYQ5,P68371,Q99519,P18074,P10619,Q16836,P00403,Q15067,Q9BW83,Q9NZ08,P17900,Q15056,O75648,Q9UG56,P04062,O96028,Q15555,Q9Y4P3,Q5XKP0,Q9Y487 31 +Leukoencephalopathy 0.36884000569962 1.3607422282131163 0.1735951646153826 1.0 0.6221956734508463 77 P17900,O75306,Q9UHX1,O00584,O96028,P18074,O95831,O43676,O75503,O75648,Q9Y375,O43681 12 +Abnormality of the abdominal wall 0.3637281790747624 1.3599957450695326 0.1738312703690283 1.0 0.6221956734508463 84 Q99519,Q9UHX1,Q15056,O75844,P07437,P35250,P18074,Q15555,Q9Y4P3,P16278,Q9NWM8,Q9Y487,Q9UBM7,Q8WYQ5,Q14739 15 +Ulnar deviation of the hand or of fingers of the hand 0.6011943349313227 1.3593087068280427 0.1740487861776976 1.0 0.6221956734508463 8 Q14739 1 +Cardiovascular calcification 0.6425596846242106 1.3591884065856816 0.1740868940531679 1.0 0.6221956734508463 7 P04062,O75844 2 +Rhabdomyolysis 0.5468376470837346 1.358980106810393 0.1741528925462689 1.0 0.6221956734508463 12 O43772,P40939 2 +Advanced eruption of teeth 0.5896357047794134 1.3577511926313617 0.1745426467753286 1.0 0.6225823602316761 9 O75844 1 +Transient ischemic attack 0.6416761156645168 1.3551507614284628 0.1753695286219956 1.0 0.622709737499844 7 O75844 1 +Abnormal diaphysis morphology 0.3984197123731769 1.3549073322540688 0.1754470832701877 1.0 0.622709737499844 48 Q9Y619,Q15056,Q13126,O75718,P35250,P07237,Q9NR77,Q9Y5S9,Q9Y4P3,P16278,Q9Y487,Q8N0X7,Q14739 13 +Hypertrophic cardiomyopathy 0.3580553384451064 1.35393320020882 0.175757690260434 1.0 0.622709737499844 90 P06280,P35250,Q13423,Q9H061,P16278,P40939,P15586,Q9Y375,O75306,Q96IX5,Q8IUX1,P00403,Q16836,O43676,P12235,Q15056,Q9H0R6,P54802,Q9Y4P3,Q9P032,Q5XKP0,Q13642,P10253,Q8N183,Q99797 25 +2 3 toe syndactyly 0.4825433915048816 1.3533719293354889 0.1759368404773182 1.0 0.622709737499844 20 Q9UBM7,Q9UHX1 2 +Short nail 0.7327589803746668 1.351895915702708 0.1764086143086829 1.0 0.622709737499844 4 O75844 1 +Ventricular arrhythmia 0.4495248324560802 1.3496960879077775 0.1771134877392881 1.0 0.6228391383141 28 O75306,O43772,Q8NFF5,P23786,P00403,P04899,P10253,P42892 8 +Abnormal peripheral nervous system physiology 0.4161584676669093 1.3438775651410626 0.1789879818711832 1.0 0.6239863971364564 41 Q9Y619,P04792,O95721,P31930,Q9NR77,O95831,Q15120,Q99720,O43681 9 +Convex nasal ridge 0.5115607639040799 1.3434500868212411 0.1791262778258864 1.0 0.6239863971364564 15 O96028,Q13363,O75844,P18074,Q6NUK1,Q96J02 6 +Fulminant hepatic failure 0.8406589470451441 1.34233644724918 0.179486930852041 1.0 0.6239863971364564 3 Q16836 1 +Pericarditis 0.7018683308491611 1.341783122477619 0.1796663261149311 1.0 0.6239863971364564 5 Q9NZ08 1 +Abnormality of long bone morphology 0.3576911240141789 1.3397499348187234 0.1803266572693695 1.0 0.6239863971364564 128 Q9Y619,Q9UHX1,P35250,P07237,Q9NR77,P16278,P48735,Q13501,Q14739,O75874,Q8N0X7,Q99519,Q15738,Q13126,O75718,O75844,O96019,Q9Y5S9,O95831,Q96J02,Q9UBM7,Q15056,O75648,Q9UG56,O96028,P22626,Q9Y4P3,Q9Y487 28 +Hemianopia 0.6797473959567218 1.336872800074284 0.1812641607397664 1.0 0.6239863971364564 6 P00403,Q9BVA1 2 +Difficulty in tongue movements 0.7777324632952557 1.3352105952824354 0.1818074300784919 1.0 0.6239863971364564 2 P10253 1 +Fetal distress 0.4796471624545285 1.333908915676756 0.1822337092850021 1.0 0.6239863971364564 20 Q8IUX1,O75306,Q8N183,O43676,Q9P032,Q9Y375 6 +Vertebral fusion 0.5845905530909472 1.332592926944969 0.1826654275638652 1.0 0.6239863971364564 9 Q9Y5S9,Q9UHX1,O96028 3 +Polydactyly 0.4327215915325791 1.3311443074857685 0.183141532361472 1.0 0.6245451022627531 33 Q9UHX1,P61978,O96028,Q9Y263,Q9UM00,Q15067,Q9BW83,Q9UBM7,Q14739,Q99519 10 +Abnormal ilium morphology 0.5250956433250664 1.3299822226540152 0.1835241286396414 1.0 0.6248713835891668 13 P16278 1 +Anorexia 0.469408346492479 1.3294697860117342 0.1836930275058532 1.0 0.6248713835891668 22 Q14108,P04062,O15460,Q9NZ08 4 +Alveolar ridge overgrowth 0.7761011419249466 1.3282144425127234 0.1841072745553773 1.0 0.6248713835891668 2 Q15392 1 +Pathologic fracture 0.5722348073665252 1.3269235901472172 0.1845339599587103 1.0 0.6248713835891668 10 Q14108,Q13126,P04062 3 +Multifocal cerebral white matter abnormalities 0.6983087754849129 1.326680489485026 0.1846143976149767 1.0 0.6248713835891668 5 P10253 1 +Sudden death 0.4689778456421505 1.3264728321298438 0.1846831282634882 1.0 0.6248713835891668 22 O15460,Q15056,P35250,Q9Y4P3,P40939,P04899 6 +Atrophy degeneration involving the corticospinal tracts 0.5406993262709465 1.3250510213601292 0.1851542294461552 1.0 0.625142867817057 12 P35637,Q13501,Q15056,P35250 4 +Mutism 0.5162215572476487 1.3229079995521122 0.1858659747237361 1.0 0.6270672816194393 14 P35637,Q13510,Q13501 3 +High hypermetropia 0.5822382789832518 1.3208516723281591 0.186550826478357 1.0 0.6272875284412968 9 Q15056,P68371,P35250 3 +Thickened ribs 0.8343533251734051 1.317864066674836 0.1875491564850331 1.0 0.6284317569191679 3 P54802,P16278 2 +Lewy bodies 0.6960034363941183 1.3168963956699535 0.1878733548278974 1.0 0.6288236376058819 5 P04062 1 +Abnormal myocardium morphology 0.3605012910347641 1.3079589547980524 0.1908872313847756 1.0 0.6375122750472586 138 P06280,P35250,Q9H061,P16278,P40939,P48735,Q9Y375,O75306,O43772,P23786,Q99519,Q14108,P18074,P00403,Q16836,P16219,O43676,Q9NZ08,Q15056,P04062,P22626,Q9Y4P3,Q5XKP0,P10253,Q99797 25 +Breast carcinoma 0.5134562847998417 1.3065411950332486 0.1913685794332547 1.0 0.6375122750472586 14 P48735 1 +Elevated hepatic transaminase 0.3615292621554131 1.306321722596408 0.1914431729594061 1.0 0.6375122750472586 81 Q9Y619,P28070,O43772,O15382,P22695,P23786,Q16836,P20674,P40939,Q5XKP0,Q15067,Q13510,P10253,Q15904,Q14739 15 +Abnormal muscle fiber morphology 0.3725164729921685 1.3058986183383945 0.1915870365244456 1.0 0.6375122750472586 55 O75340,Q70HW3,P05067,P61978,Q99720,P23786,P22626,P35637,P00403,O14979,O95831,O43676,Q9H2D1,O75648,Q13642,P31483,Q13501 17 +Fatigue 0.368751503512175 1.30458249592995 0.192035051816213 1.0 0.6375122750472586 68 Q9NZ08,O15460,P07737,P06280,Q92804,P04062,P18074,Q15165,P35637,Q14739,Q13501 11 +Abnormal talus morphology 0.4838284412830955 1.3036057590310888 0.1923680360854702 1.0 0.6375122750472586 18 Q9UHX1,O75844 2 +Depression 0.3597922153044843 1.303027663021643 0.1925653175363186 1.0 0.6375122750472586 83 O15460,Q15056,P07737,P31930,P06280,P04062,Q92804,P35250,P35637,Q15165,P50897,P00403,Q6DKK2,O43681,Q13501 15 +Malignant neoplasm of the central nervous system 0.4962354359724958 1.3010894705789258 0.1932278314687174 1.0 0.6380559607543556 16 P48735,O75874 2 +Abnormal macrophage morphology 0.671190120125257 1.2999886256876931 0.1936048675998138 1.0 0.6380559607543556 6 Q13510,P16278,Q99519 3 +Foam cells 0.671190120125257 1.2999886256876931 0.1936048675998138 1.0 0.6380559607543556 6 Q13510,P16278,Q99519 3 +Proptosis 0.4255822615875438 1.2997706172854273 0.1936795988792137 1.0 0.6380559607543556 34 P61978,O75718,Q13409,P16435,O75844,Q13363,P07237,Q6NUK1,O96028,Q969G3,Q96J02,P57081,Q9UBM7,O75431 14 +Aplasia hypoplasia of the retina 0.7201470078561492 1.299596347143482 0.1937393523158714 1.0 0.6380559607543556 4 Q99519 1 +Enlarged thorax 0.5658145150977647 1.2940354337991824 0.1956531817308846 1.0 0.6406957700439583 10 Q14739 1 +Acute coronary syndrome 0.4863774192596123 1.2939417635333872 0.1956855373015393 1.0 0.6406957700439583 17 Q9NZ08,Q15056,P06280,O75844,P35250 5 +Adrenocortical abnormality 0.7671288743882574 1.289756870550471 0.1971350869754886 1.0 0.6412409315962306 2 P10644 1 +Primary hypercortisolism 0.7671288743882574 1.289756870550471 0.1971350869754886 1.0 0.6412409315962306 2 P10644 1 +Hypermetric saccades 0.7667210440456753 1.2880097960119736 0.197742553204665 1.0 0.6412409315962306 2 O14773 1 +Hand muscle weakness 0.5756333890596314 1.287847902619315 0.1977989135794149 1.0 0.6412409315962306 9 Q13501,Q9NR77,P31483,Q15120 4 +Abnormality of chorioretinal pigmentation 0.6885357377171224 1.285189611832112 0.1987260328478437 1.0 0.6419274611213306 5 Q5XKP0 1 +Limited extraocular movements 0.7150866247234934 1.2786048325609949 0.2010362473540072 1.0 0.6441305399140624 4 Q9BVA1 1 +Abnormality of temperature regulation 0.3570144730885427 1.2785388614284343 0.2010594914909191 1.0 0.6441305399140624 84 Q9NZ08,O15460,O43772,P28070,P06280,P35270,P23786,P18074,Q9NR77,Q5XKP0,Q13510,P10253,Q14739 13 +Optic disc pallor 0.4147260952898414 1.2779089468074998 0.2012815330952437 1.0 0.6441305399140624 38 Q9UG56,Q8WWV3,Q9H061,O95831,O43676,Q9Y375 6 +Multiple lipomas 0.7642740619902166 1.277529455154213 0.2014153882225366 1.0 0.6441305399140624 2 O95140 1 +Generalized osteosclerosis 0.7642740619901988 1.2775294551541363 0.2014153882225637 1.0 0.6441305399140624 2 Q15392 1 +Cutaneous finger syndactyly 0.7642740619901978 1.277529455154133 0.2014153882225648 1.0 0.6441305399140624 2 Q9Y619 1 +Incoordination 0.3699166426760063 1.276765333237986 0.2016851079253703 1.0 0.6441305399140624 54 Q9Y619,Q01105,O75340,O95140,P04062,Q9NR77,Q6DKK2,P40939,Q15067,O75503,Q13510,P31483,P37198,O43681,Q13501 15 +Abnormal urine cytology 0.4192931292961209 1.275864809708215 0.2020033126238882 1.0 0.6444311515402533 35 Q14108,O15460,P04062,P09601 4 +Calvarial skull defect 0.6654851423574173 1.2753764482144114 0.2021760306843361 1.0 0.6444311515402533 6 Q14739 1 +Intracranial hemorrhage 0.4663789772291962 1.2752193445445097 0.2022316161740609 1.0 0.6444311515402533 21 P05067,P04062,O75844,P23786,Q02978 5 +Glioma 0.5727030292425958 1.2731895502492825 0.2029507877797915 1.0 0.6447258456999404 9 P48735 1 +Abnormality of neutrophil morphology 0.6857077714023494 1.2731782435898338 0.2029547990257807 1.0 0.6447258456999404 5 Q14739 1 +Progressive visual loss 0.4748570829627156 1.2722448895202063 0.203286122754148 1.0 0.6450032431431828 19 O75306,P50897,Q969G3,O75503,Q99519 5 +Microdontia 0.456163960026368 1.2714851281428092 0.2035561148728921 1.0 0.6453969147546967 23 Q9Y619,Q15056,P35250,Q6NUK1,P07237,Q15555,Q9Y4P3,Q9UM00,Q9Y487,P57081 10 +Aspiration pneumonia 0.4454681453402788 1.2695521857287135 0.204244190394701 1.0 0.6458593723872329 25 O95721,P04062,Q6NUK1,P16278,Q13510 5 +Paroxysmal ventricular tachycardia 0.7601957585644414 1.2600709046880314 0.2076437850630537 1.0 0.6513535186765153 2 P04899 1 +Muscle fibrillation 0.5125989930855772 1.257774331040401 0.2084733814234833 1.0 0.6530259524565069 13 Q13510,O95831 2 +Abnormal sacrum morphology 0.4432445400472909 1.2531258364653477 0.210159914739038 1.0 0.6546042254974856 25 Q15056,P61978,O96028,P35250,Q03164,Q9Y4P3,Q9UM00,Q14739 8 +Abnormal carotid artery morphology 0.5277257978428151 1.253125403190074 0.2101600723957561 1.0 0.6546042254974856 12 Q15056,O75844,P35250 3 +Abnormal circulating carboxylic acid concentration 0.3599612277603208 1.2495850506103858 0.2114511669004815 1.0 0.6553884748870965 76 Q9Y619,P41440,O15382,P13804,P05067,Q16134,P22695,P23786,P35270,P20674,Q5XKP0,P48735,Q99797,Q14739 14 +Stroke 0.4426471010063916 1.2487093915907164 0.2117713845897504 1.0 0.6553884748870965 25 Q15056,P05067,O95721,P06280,O75844,P35250,P00403 7 +Neoplasm of the pituitary gland 0.5035787892978781 1.2479512175078882 0.2120489224635675 1.0 0.6553884748870965 14 P48735 1 +Steppage gait 0.4790367548564005 1.2467004394883738 0.2125073576284384 1.0 0.6553884748870965 17 O95140,P04792,Q9NR77,Q15120,Q13642,P31483,Q13501 7 +Abnormality of corneal size 0.428294634729021 1.246629842721953 0.2125332540812563 1.0 0.6553884748870965 31 Q15056,O96028,P07437,P35250,P18074,Q15555,Q9NWM8,Q96EK5 8 +Arm dystonia 0.7072358980072908 1.246037565818772 0.2127506041060767 1.0 0.6553884748870965 4 P35637 1 +Epispadias 0.7069149600810739 1.2447062949024317 0.2132397312221261 1.0 0.6554269153547352 4 P48651,Q9Y619 2 +Aplasia hypoplasia of the hallux 0.4779351538008864 1.2395995159339808 0.2151235598001952 1.0 0.6583644286191174 17 Q9UHX1,O96028,Q13363,O96019,O75648 5 +Abnormal upper motor neuron morphology 0.5551657275761748 1.239375108472217 0.2152066151852509 1.0 0.6583644286191174 10 P35637,Q13501 2 +Thoracic hypoplasia 0.4516130169807716 1.2390759170946626 0.2153173847600511 1.0 0.6583644286191174 23 Q9UHX1,P04062,Q14739 3 +Renal cortical cysts 0.6775885886824066 1.2386850232659317 0.2154621672036016 1.0 0.6583644286191174 5 Q16134 1 +Posteriorly rotated ears 0.3578157511162058 1.2383792342825493 0.2155754767021291 1.0 0.6583644286191174 78 Q9Y619,Q9UHX1,P35250,Q6NUK1,Q15392,P42892,P07437,P23786,P11233,Q15738,Q9Y5S9,Q9UM00,Q96J02,Q9BW83,Q9UBM7,O43505,Q15056,P04062,O96028,Q9Y263,Q15555,Q9Y4P3 22 +Long fingers 0.36486960540093 1.238086638027057 0.2156839378406287 1.0 0.6583644286191174 62 Q15738,Q9UHX1,Q06136,O96028,P07437,P23786,Q9Y263,Q03164,Q15555,Q969G3,Q96EK5,P42892 12 +Aplasia hypoplasia of the clavicles 0.5655634682224785 1.2374398358882357 0.2159238373622383 1.0 0.658642160450469 9 Q9Y619,Q15738,O75844,O75431 4 +Myoglobinuria 0.5651460414007724 1.235348221448575 0.2167009343396198 1.0 0.6591941076919796 9 Q16836,P40939 2 +Shyness 0.7540783034257759 1.2339063313886962 0.2172378099933836 1.0 0.660373081512533 2 Q06787 1 +Renal salt wasting 0.7532626427406237 1.2304200651766926 0.2185398433284289 1.0 0.662135724722412 2 Q13423 1 +Cavum septum pellucidum 0.613975725913394 1.2282495932505224 0.2193532869225227 1.0 0.6636112093422148 7 Q9Y5S9,O96028,Q9BVA1,Q14738 4 +Abnormality of the tongue 0.3618683885003935 1.2267160991387445 0.2199293146352852 1.0 0.6640992009954811 68 O15460,Q15056,P10253,O75844,P35250,Q6NUK1,Q9Y4P3,Q969G3,P16278,O95831,O75648,Q13510,Q9UBM7,O75431,Q99519 15 +Mediastinal lymphadenopathy 0.7023401686086295 1.2257313187969725 0.2202998003875289 1.0 0.6640992009954811 4 O15460 1 +Hip pain 0.6738603953308259 1.2228442057550242 0.2213885453405617 1.0 0.6649000356408692 5 O75844,P22626 2 +Adipose tissue loss 0.5621128189366575 1.2201452170593778 0.2224098299719319 1.0 0.6665492083958444 9 P18074,O75844 2 +Abnormality of facial musculature 0.3645007115213657 1.219735262200894 0.2225652495801553 1.0 0.6665492083958444 55 Q9BUF5,Q9UHX1,P04062,P35270,Q14738,P16219,Q969G3,Q13510,P10253,Q13501 10 +Death in infancy 0.4000956536596587 1.2191963956252052 0.2227696596656587 1.0 0.6665492083958444 42 Q4G0N4,O75718,P04062,O43464,Q6NUK1,Q9BZH6,P18074,Q9Y5S9,P20674,P16278,Q15067,Q9H0R6,Q00059,Q15904 14 +Aplasia hypoplasia involving the pelvis 0.5506465658824506 1.216142115918084 0.2239307893726068 1.0 0.6673654911641459 10 Q15738,O96028,O95831,O75431 4 +Ulnar claw 0.8069175961964854 1.211515946528954 0.2256977268175339 1.0 0.670748952363444 3 P04792 1 +Abnormal foveal morphology 0.6987700795790202 1.210926359940165 0.2259236289599693 1.0 0.670748952363444 4 Q99519 1 +Abnormality of coagulation 0.3919305338953949 1.2101846800214402 0.2262080353306952 1.0 0.670748952363444 45 Q9Y619,Q9Y487,O75340,O75874,Q9Y5S9,Q16836,P40939,Q5XKP0,P48735,O75648 10 +Abnormal meningeal morphology 0.4896340295135032 1.209953280468914 0.226296820627601 1.0 0.670748952363444 15 Q9UHX1,Q15904 2 +Abnormal circulating pyruvate family amino acid concentration 0.4971378686037179 1.2096485284181857 0.2264137883514858 1.0 0.670748952363444 14 Q8IUX1,P22695,P20674,O75880,Q5XKP0,Q99797 6 +Abnormal circulating proteinogenic amino acid derivative concentration 0.4971378686037179 1.2096485284181857 0.2264137883514858 1.0 0.670748952363444 14 Q8IUX1,P22695,P20674,O75880,Q5XKP0,Q99797 6 +Abnormal temper tantrums 0.5596277555880791 1.207684345944635 0.2271687015977188 1.0 0.6720850616499735 9 P04062,Q9BVA1 2 +Conspicuously happy disposition 0.7471451876019564 1.204292812129701 0.2284764238833068 1.0 0.6722815022448829 2 P55795 1 +Medial flaring of the eyebrow 0.7471451876019445 1.2042928121296492 0.2284764238833267 1.0 0.6722815022448829 2 Q9BW83 1 +Preaxial polydactyly 0.6084849624368119 1.20304146098563 0.2289602765973653 1.0 0.6722815022448829 7 Q9UHX1 1 +Perseveration 0.5689607279646587 1.2020343120306785 0.229350234496851 1.0 0.6722815022448829 8 P35637,Q13501 2 +Hirsutism 0.3764787154713349 1.1999524020223034 0.2301578266983777 1.0 0.6722815022448829 50 Q13155,Q06136,P07437,Q6NUK1,Q9Y263,P54802,Q15555,Q03164,P16278,Q969G3,P10644,Q9BW83 12 +Impaired social interactions 0.4102659892649843 1.199780180932757 0.2302247232984575 1.0 0.6722815022448829 35 Q8IUX1,O75306,Q9UHX1,Q8N183,Q9NPL8,O43464,O43676,Q15067,Q5XKP0,Q9P032,Q9Y375 11 +Oculomotor apraxia 0.4505397891712558 1.1975513616453546 0.2310917208726468 1.0 0.6722815022448829 22 Q9Y3C8,P05067,Q9NQT5,Q96GM8,P04062,P35270,Q10713,O14773,Q13501 9 +Axial dystonia 0.8032942196497872 1.1974975693749006 0.2311126743792009 1.0 0.6722815022448829 3 P35637 1 +Weakness of muscles of respiration 0.433637374697399 1.1959002670990388 0.231735480925167 1.0 0.6733803775518796 26 O95140,P22626,Q13642,P09651,O95831,Q15067,Q13510,P10253 8 +Wide intermamillary distance 0.4791729209222846 1.1941787142351947 0.2324080676072204 1.0 0.6745018917498268 16 P61978,P23786,P07437,Q15555,Q9UM00,Q9UBM7,Q96EK5 7 +Abnormality of circulating leptin level 0.6944832933005818 1.1931538851610457 0.232809111215078 1.0 0.6752227533798626 4 O75844 1 +Anonychia 0.5555582142311237 1.187269187262954 0.2351214579309424 1.0 0.6798534646829184 9 Q14739 1 +Hyperkeratosis 0.3894828179700018 1.1870197380307217 0.2352198350332919 1.0 0.6798534646829184 45 Q06136,O95721,P06280,O75844,P04062,Q9NWM8,Q99519 7 +Abnormality of circulating enzyme level 0.35286039712361 1.1867456068152695 0.2353279797489369 1.0 0.6798534646829184 79 P35250,P40939,Q15120,Q5JRX3,P31483,Q13501,Q6ZXV5,O43772,Q8NFF5,P23786,Q9NWM8,O75340,Q16836,O95831,O43505,Q15056,P22626,Q13642,Q9Y4P3,O14979,O75648,Q9H0R6,P10253 23 +Abnormality of the proximal phalanx of the thumb 0.7426590538336041 1.1851571741793512 0.235955308912874 1.0 0.6803326801314485 2 Q15233 1 +Symphalangism of middle phalanx of finger 0.7426590538336041 1.1851571741793512 0.235955308912874 1.0 0.6803326801314485 2 Q15233 1 +Splenomegaly 0.3538703328620921 1.184572975967121 0.2361863270815676 1.0 0.6805551300858459 77 Q14108,Q9NZ08,P28070,Q99519,P04062,Q15392,P16278,Q13510,P10253,Q15904,Q14739 11 +Parkinsonism 0.4437243785431726 1.1827470552738255 0.2369094092138999 1.0 0.6811299399076585 23 P05067,P31930,P04062,P35637,Q99720,Q13501 6 +Paresthesia 0.4528437628766071 1.182014526699856 0.2371999368886772 1.0 0.6811299399076585 21 Q9NZ08,O15460,O95140,P05067,P06280,Q9NR77 6 +Increased adipose tissue 0.6914489309169836 1.1805776395112813 0.2377705508130814 1.0 0.682009822468391 4 P31751 1 +Spina bifida occulta 0.4920452041078029 1.1793164419666529 0.2382721935288367 1.0 0.6825634144935525 14 P35250,Q9UHX1,Q15056 3 +Telangiectasia 0.4270036110133355 1.1773307773178558 0.2390635071842435 1.0 0.6839443028951546 28 O75306,P06280,P10619,Q14739,Q99519 5 +Telangiectasia of the skin 0.4840048318782443 1.175529085887545 0.2397831076817704 1.0 0.6842370772660326 15 P06280,Q14739 2 +Poor eye contact 0.4217804705946399 1.173788634909111 0.2404796973441925 1.0 0.6842370772660326 30 O43676,Q5XKP0,Q9UHX1,Q9Y375 4 +Episodic vomiting 0.562887349596625 1.1723120445854782 0.2410717976199055 1.0 0.6842370772660326 8 Q9Y619,P00403,P22695 3 +Sound sensitivity 0.5626143631669958 1.1709757014440434 0.2416085442487263 1.0 0.6842370772660326 8 P17900,Q15056,P35250 3 +Hyperacusis 0.5626143631669958 1.1709757014440434 0.2416085442487263 1.0 0.6842370772660326 8 P17900,Q15056,P35250 3 +Retinal vascular tortuosity 0.527497560124853 1.1698592043130909 0.2420576335068629 1.0 0.6842370772660326 11 O75306,Q15056,P35250,Q9Y4P3,Q8WYQ5 5 +High myopia 0.5623709394005105 1.1697840514727025 0.2420878833572515 1.0 0.6842370772660326 8 O15460 1 +Shawl scrotum 0.6886171257982563 1.1688443677282878 0.2424663410070406 1.0 0.6842370772660326 4 Q9Y619,Q9UM00 2 +Cholestasis 0.359412640746683 1.1687703330039114 0.2424961761671595 1.0 0.6842370772660326 58 P61916,P13804,Q16134,P00374,P40939,Q13510,Q9UBM7,Q15904,Q14739 9 +Pigmentary retinopathy 0.4051775635003444 1.1681328601639855 0.2427531773683682 1.0 0.6842370772660326 36 O75306,Q9UG56,P00403,Q16836,P40939,Q15067,Q9BW83 7 +Areflexia of lower limbs 0.4550460744237222 1.1675852521070214 0.2429741018809053 1.0 0.6842370772660326 20 P04792,Q15041,Q9NR77,Q15067,Q15120,Q13501 6 +Cold induced muscle cramps 0.7952988412716396 1.1665968061547871 0.2433732337620759 1.0 0.6842370772660326 3 Q9NR77 1 +Sparse eyelashes 0.4825327457825441 1.1665184848115029 0.2434048794034762 1.0 0.6842370772660326 15 P48449 1 +Hyperextensible skin 0.5120512108633413 1.1659067840638495 0.2436521358114405 1.0 0.6842370772660326 12 Q9UHX1,P04062 2 +Submucous cleft of soft and hard palate 0.4588250770689551 1.165423214521943 0.2438477249721213 1.0 0.6843518322028508 19 Q9Y619,O43505,O75844,Q14738,Q15392,Q8WYQ5 6 +Short long bone 0.4456869644210503 1.163455874474432 0.2446445910708159 1.0 0.6861528384947488 22 Q9UHX1 1 +Exodeviation 0.4736073134130703 1.159179355884507 0.246383084471373 1.0 0.6880211864997545 16 Q9UHX1 1 +Abnormality of the gallbladder 0.4235857910837913 1.151011743002004 0.2497274045153461 1.0 0.6912277998506653 28 Q15056,P04062,O96028,P35250,Q9UBM7,O43681 6 +Scotoma 0.5239477300823159 1.1508536969155536 0.2497924295446276 1.0 0.6912277998506653 11 Q9H061,Q8WWV3 2 +Aplasia hypoplasia affecting the fundus 0.4524923500123154 1.1502316057743085 0.2500484919197523 1.0 0.6912277998506653 20 Q86YV9,Q9UHX1,O95721,P61978,Q9BZH6,Q99519 6 +Aortic regurgitation 0.4436044141711415 1.1488061125533369 0.2506359383290126 1.0 0.6919309713568647 22 Q9UHX1,O75844 2 +Glycosuria 0.5580740839439212 1.1487460463933985 0.2506607127578855 1.0 0.6919309713568647 8 Q16134 1 +Abnormal macular morphology 0.4271744187074901 1.1473391082982818 0.2512414967214842 1.0 0.6919309713568647 26 Q86YV9,P04062,P18074,P50897,Q9UM00,Q13510,Q99519 7 +Myoclonic seizure 0.3919965638624561 1.1452529373184666 0.2521043951738091 1.0 0.6922841768357808 42 Q9Y619,P04062,Q8WWV3,P16278,Q5XKP0,O75503,Q13510 7 +Bilateral microphthalmos 0.6555785233866579 1.1451864862836938 0.2521319150884267 1.0 0.6922841768357808 5 Q9UHX1 1 +Abnormality of cardiovascular system electrophysiology 0.3493669672979834 1.14492907550464 0.2522385385053303 1.0 0.6922841768357808 79 O15460,O43772,O75306,Q15056,Q8NFF5,P06280,P04062,P23786,P35250,O43464,P00403,Q16836,Q9Y4P3,P40939,P10253,P42892,Q99519 17 +Delusions 0.4788763693317482 1.1441243054696977 0.2525720890956051 1.0 0.6922841768357808 15 P04062,O43681,Q9BQE5 3 +Abnormal connection of the cardiac segments 0.3958016622290091 1.143546241192135 0.2528118672537316 1.0 0.6922841768357808 40 O15460,Q9UHX1,Q15056,O75844,P35250,Q9Y5S9,Q9Y4P3,Q969G3,Q8WYQ5 9 +Astrocytoma 0.6349482275942333 1.1434789243378256 0.2528398002534291 1.0 0.6922841768357808 6 P48735 1 +Macroglossia 0.4246812417152171 1.1432496874917717 0.2529349377722409 1.0 0.6922841768357808 27 Q15056,P35250,Q9Y4P3,P16278,P10253 5 +Arterial thrombosis 0.63460975351874 1.142016735623692 0.2534470633195691 1.0 0.6932568714053521 6 Q9NZ08 1 +Coronal craniosynostosis 0.7874337005304004 1.136250273504039 0.2558518356421966 1.0 0.6982387500596825 3 Q6NUK1,P07237 2 +Muscle weakness 0.3764045923677223 1.1335521326148692 0.2569824615053977 1.0 0.6982387500596825 222 Q8N183,Q9UHX1,P04792,O95721,Q92804,Q6NUK1,P09651,Q9NR77,P40939,Q15120,P10644,P31483,P37198,Q9Y375,Q14739,Q13501,O75306,O43772,P07737,P48651,Q16134,Q8NFF5,P23786,Q9BZH6,Q15165,Q96BR5,Q969G3,Q9NWM8,Q13510,Q99720,Q9Y3E5,Q8N0X7,Q99519,P41440,Q9BUF5,P13804,O75340,Q8IUX1,Q13126,P00374,P00403,P16219,O95831,O43676,Q15067,Q6DKK2,Q70HW3,O43505,P17900,O15460,O95140,Q96GM8,P61978,P35270,P22626,P35637,Q9Y263,Q9P032,Q5XKP0,O14979,O75648,Q13642,P10253,O43681 64 +Diaphyseal thickening 0.7866177070583519 1.133105145103941 0.2571701009741707 1.0 0.6982387500596825 3 P48651,Q14739 2 +Positive romberg sign 0.5548561665548142 1.1329875029807064 0.2572195013890934 1.0 0.6982387500596825 8 P41440,Q8IV08,O95140,P18887 4 +Abnormality of the alveolar ridges 0.6799109594505631 1.1327974877567026 0.2572993067067899 1.0 0.6982387500596825 4 Q9UBM7 1 +Nevus 0.4319053223008899 1.1322536178575653 0.2575278239452241 1.0 0.6982387500596825 24 Q9UHX1,Q15056,P35250,Q6NUK1,P18074,Q9Y5S9,Q9Y4P3 7 +Pectus excavatum 0.3559275907397593 1.1306051790133331 0.258221306719933 1.0 0.6982387500596825 58 Q9UHX1,Q15056,P61978,O75718,P04062,P07437,P35250,Q03164,Q15555,Q9Y4P3,Q96J02,Q9Y487,O75431 13 +Abnormality of abdominal situs 0.7858869054258644 1.1302889327205998 0.2583544964552358 1.0 0.6982387500596825 3 O96028 1 +Aplasia hypoplasia of the pubic bone 0.7858869054258644 1.1302889327205998 0.2583544964552358 1.0 0.6982387500596825 3 O96028 1 +Rib segmentation abnormalities 0.7858869054258644 1.1302889327205998 0.2583544964552358 1.0 0.6982387500596825 3 O96028 1 +Hypoplastic pubic rami 0.7858869054258644 1.1302889327205998 0.2583544964552358 1.0 0.6982387500596825 3 O96028 1 +Preaxial foot polydactyly 0.7858869054258644 1.1302889327205998 0.2583544964552358 1.0 0.6982387500596825 3 O96028 1 +Craniofacial asymmetry 0.7858869054258644 1.1302889327205998 0.2583544964552358 1.0 0.6982387500596825 3 O96028 1 +Abnormal corpus striatum morphology 0.4905465876995732 1.1297453145858063 0.2585835569970065 1.0 0.6982387500596825 13 O75306,O95831,Q9BVA1 3 +Absent toe 0.4532500227992648 1.1281416827482484 0.2592600879489031 1.0 0.6985758834775495 19 Q9UHX1,O96028,Q13363,O96019,O75648 5 +Hypoplasia of the iris 0.6786074243633835 1.1274043738630883 0.2595715506426155 1.0 0.6985758834775495 4 O96028,Q13363 2 +Rieger anomaly 0.6786074243633835 1.1274043738630883 0.2595715506426155 1.0 0.6985758834775495 4 O96028,Q13363 2 +Dysphonia 0.4204435323061585 1.1267831634037035 0.2598341707156619 1.0 0.6986301137236309 28 Q15056,P35250,Q02978,P18074,Q9Y4P3,Q13510,Q6DKK2,Q99519 8 +Occipital encephalocele 0.7841697266421914 1.1236737392442058 0.261151460947671 1.0 0.7000392266821801 3 O43505,Q6ZXV5 2 +Inguinal hernia 0.3548622486552666 1.1224558188310485 0.261668682604089 1.0 0.7000392266821801 60 Q9UHX1,Q15056,P07437,P35250,Q15555,P16278,Q9NWM8,Q9Y487,Q8WYQ5,Q99519 10 +Slow decrease in visual acuity 0.6300602196077232 1.1223653862980434 0.261707115353605 1.0 0.7000392266821801 6 O75306,Q969G3 2 +Genu valgum 0.4305272398025501 1.1221875624798772 0.2617826997359995 1.0 0.7000392266821801 24 Q9Y619,Q15056,P35250,Q9NR77,Q9Y4P3,P16278,Q8N0X7 7 +Low set posteriorly rotated ears 0.3587018802588308 1.1185239712694033 0.263343274417938 1.0 0.7030775510376895 53 Q8NCH0,P16435,P35250,Q6NUK1,Q10713,Q15392,P08754,P07437,Q13363,Q9Y5S9,Q9UM00,Q96J02,P37268,Q9BW83,Q9UBM7,Q15056,O96028,P04062,Q9Y263,Q15555,Q9Y4P3 21 +Abnormal circulating carbohydrate concentration 0.4095455852309864 1.1180930233920257 0.2635272657872003 1.0 0.7030775510376895 32 Q8IUX1,O75306,Q8N183,Q9NPL8,P22695,O95831,O43676,Q5JRX3,Q9P032,Q9Y375,Q70HW3 11 +Osteolysis involving bones of the feet 0.7816949943498896 1.114145570173272 0.2652167415491651 1.0 0.7043358179211672 3 O75844 1 +Abnormality of the distal phalanges of the toes 0.7816949943498896 1.114145570173272 0.2652167415491651 1.0 0.7043358179211672 3 O75844 1 +Foot acroosteolysis 0.7816949943498896 1.114145570173272 0.2652167415491651 1.0 0.7043358179211672 3 O75844 1 +Temporal pattern 0.6482181583292601 1.1139506570199629 0.2653003555633426 1.0 0.7043358179211672 5 P04062 1 +Endocarditis 0.6477565042534428 1.1119924215003292 0.2661414088033524 1.0 0.7052080518840061 5 Q9NZ08 1 +Generalized joint laxity 0.5163687961215836 1.1102508677980047 0.266890938507381 1.0 0.7052080518840061 11 Q9UHX1 1 +Impaired mastication 0.6267758754060881 1.1081825095593876 0.2677830028895793 1.0 0.7052080518840061 6 O15460 1 +Abnormal size of the palpebral fissures 0.3506379039203443 1.1072802354718645 0.2681727868346306 1.0 0.7052080518840061 70 Q9Y619,Q9UHX1,Q15056,P38159,O75844,P07437,P35250,Q6NUK1,O96019,Q03164,O60701,Q15555,Q9Y4P3,O75648,Q8WYQ5 15 +Lissencephaly 0.3857138279422957 1.1072495463144918 0.2681860514539655 1.0 0.7052080518840061 43 Q15738,Q6ZXV5,P13804,Q9BVA1,O95721,Q16134,Q86XL3,P23786,Q9Y487,Q15392,Q96EK5 11 +Elevated circulating growth hormone concentration 0.724306688417621 1.1071418650389264 0.2682325975527793 1.0 0.7052080518840061 2 P10644 1 +Pituitary prolactin cell adenoma 0.724306688417621 1.1071418650389264 0.2682325975527793 1.0 0.7052080518840061 2 P10644 1 +Diaphragmatic weakness 0.7795016002883941 1.1057061542051128 0.2688537254300061 1.0 0.705721084615381 3 P10253 1 +Obsessive compulsive trait 0.6724882870687624 1.1021045283063513 0.2704162309670526 1.0 0.7085610127768208 4 O75503,Q06787 2 +Morphological abnormality of the corticospinal tract 0.4780566761258855 1.095830536579971 0.2731529423118894 1.0 0.7110979775429589 14 P35637,Q13501,Q15056,P35250 4 +Abnormality of the lymphatic system 0.3364441669831104 1.0948548074278288 0.2735802506733449 1.0 0.7117914404283555 122 Q14108,Q9NZ08,O15460,P28070,Q99519,O75874,P04062,Q15392,Q01844,P10619,P16278,P48735,Q13510,P10253,Q15904,Q14739 16 +Abnormality of epiphysis morphology 0.3898230812062308 1.0900208522328776 0.2757039587279017 1.0 0.7165882975919663 40 Q9Y619,Q9UG56,O95831,P16278,Q9UBM7,Q14739,Q99519 7 +Vasculitis 0.5459193150805114 1.0892175570138385 0.276057958382832 1.0 0.7165882975919663 8 Q9NZ08 1 +Abnormal tongue physiology 0.483579379573875 1.0891857067111566 0.276072000700138 1.0 0.7165882975919663 13 Q13510,O95831 2 +Shallow orbits 0.5455984824075927 1.087646278242695 0.2767512922939881 1.0 0.7177788069571238 8 O75844,O75431,P07237 3 +Abnormal thrombosis 0.4346564383703143 1.085753388398864 0.2775881134446938 1.0 0.7177788069571238 22 P48735,O75874,Q9NZ08 3 +Bladder diverticulum 0.5451243234748315 1.0853241119476618 0.2777781302618218 1.0 0.7177788069571238 8 Q9NWM8,Q15056,P35250 3 +Bradykinesia 0.4467315109022652 1.0844813328461975 0.2781514392932562 1.0 0.7177788069571238 19 P31930,P04062,P35270,O43464,Q96IX5,P12235,Q6DKK2 7 +Nonketotic hypoglycemia 0.6409178855542235 1.0830003328722348 0.2788082752904608 1.0 0.7177788069571238 5 P23786 1 +Keratitis 0.5112013524365463 1.082553580934881 0.2790066205347212 1.0 0.7177788069571238 11 Q9NZ08,Q14739 2 +Paraplegia paraparesis 0.3501359291081884 1.0794723885139637 0.2803771962054362 1.0 0.7197378635035662 64 Q9Y619,O75306,P04062,P18074,P35637,O95831,Q5XKP0,Q13510,Q6DKK2,Q13501 10 +Lower limb muscle weakness 0.404679895173904 1.0784905649322514 0.2808148900936063 1.0 0.7204433056171813 32 P04792,O95140,Q9NR77,P40939,Q969G3,Q15120,Q13510,P37198,Q8N0X7 9 +Abnormal upper limb bone morphology 0.3481024723667369 1.0780246058987104 0.2810227754295049 1.0 0.7205586873766379 70 Q9UHX1,P16435,P08236,P35250,Q6NUK1,P16278,P10644,Q14739,P98175,P48651,O00116,O75844,Q13363,O96019,Q9Y5S9,P55011,Q9UBM7,O75431,Q15056,O96028,Q9Y4P3,O75648,Q96AY3 23 +Alopecia 0.3957662077229384 1.0768595976343682 0.2815429952088941 1.0 0.7207797496663775 35 P48449,O75844,Q06136 3 +Abnormality of bone mineral density 0.3298955490098089 1.0765925662154596 0.2816623267221263 1.0 0.7207797496663775 113 P06280,P35250,P16278,Q15392,Q9Y375,Q13501,Q14739,Q9NWM8,Q13510,Q14108,Q13126,O75718,O75844,P18074,O95831,Q15056,P04062,O96028,P51809,Q9Y487 20 +Horizontal nystagmus 0.4455218705883768 1.0763721822889707 0.2817608381580752 1.0 0.7207797496663775 19 P04062,Q9H061,O95831 3 +Overlapping toe 0.4603576924582185 1.0756732350313047 0.2820734216167238 1.0 0.7211622796594042 16 Q9UHX1 1 +Mandibular prognathia 0.4155434260741263 1.0735515935194944 0.2830237029889249 1.0 0.7218246993898492 27 Q9UHX1 1 +Insulin resistant diabetes mellitus 0.542396896130434 1.0719675231365862 0.2837346195959114 1.0 0.7225655577217525 8 P31751,O75844 2 +Thin skin 0.428226515396424 1.0716177035305725 0.2838917783638839 1.0 0.7225655577217525 23 Q9Y619,Q6ZXV5,Q13126,O75844,P18074,P10644,O75431 7 +Abnormality of the calcaneus 0.6182001796860638 1.0711709181823057 0.2840925853217562 1.0 0.7225655577217525 6 Q14739 1 +Neoplasm of the breast 0.4440162285332996 1.0662759764041712 0.2862989059801506 1.0 0.7235688329154765 19 P48735 1 +Myopathy 0.3433802102552751 1.0662754384156576 0.2862991491047131 1.0 0.7235688329154765 78 P35250,P09651,P40939,P31483,Q9Y375,Q13501,O75306,Q8NFF5,P23786,Q9NWM8,O75340,Q13126,P00403,P16219,O43676,Q15056,P22626,Q9Y4P3,O14979,O75648,Q13642,Q9P032 22 +Abnormality of the chin 0.3500054758191026 1.0643665059395195 0.287162700773907 1.0 0.7244380482822199 57 Q13155,Q9UHX1,Q15056,P48651,Q9UQR1,O75844,P35250,Q6NUK1,O60701,Q9Y4P3,P16278,P11233,P10644,P55011,Q06787,Q96EK5,Q96J02 17 +Distal peripheral sensory neuropathy 0.7677495793046254 1.060586898938211 0.2888776790075087 1.0 0.7251993661922895 3 P40939 1 +Abnormal qt interval 0.5774348967428528 1.0604298385360411 0.2889490934486631 1.0 0.7251993661922895 7 Q16836 1 +Ketotic hypoglycemia 0.76729185867058 1.058833235314801 0.2896757346541272 1.0 0.7251993661922895 3 P16219 1 +Abnormal renal insterstitial morphology 0.5299554913885965 1.0586894822009487 0.2897412194624071 1.0 0.7251993661922895 9 Q15056,P23786,P35250 3 +Keratoconjunctivitis 0.5198592682324223 1.0575312586942776 0.2902691963590902 1.0 0.7251993661922895 10 Q9NZ08,Q14739 2 +Hamartoma 0.4569410293126363 1.054107724636704 0.2918335999692765 1.0 0.7255649312333389 16 P48735 1 +Abnormality of toe 0.3351150733303419 1.0535420903413892 0.2920926141803053 1.0 0.7256043180493575 125 Q9UHX1,P04792,P21964,P35250,Q9NR77,P10644,Q14739,Q96C86,P23786,Q96BR5,P11233,Q969G3,Q13510,Q99720,Q9Y3E5,Q8N0X7,Q15738,O75844,Q13363,O96019,Q9UM00,Q96J02,P55011,Q9UBM7,O75431,Q15056,O95140,P61978,P04062,O96028,Q14738,Q9Y263,Q03164,Q9Y4P3,O75648,Q13642 36 +Abnormal tongue morphology 0.34908461224639 1.05335668769623 0.2921775470146746 1.0 0.7256043180493575 56 O15460,Q15056,P10253,O75844,P35250,Q9Y4P3,P16278,O75648,Q9UBM7,Q99519 10 +Apraxia 0.3490642783868223 1.0520271133611765 0.2927871102284898 1.0 0.7262079043660925 54 Q9Y619,Q9BVA1,P05067,Q96GM8,P04062,P35270,P35637,O75648,Q6DKK2,Q8N0X7,Q13501 11 +Prominent superficial blood vessels 0.5186874154857735 1.051490138574874 0.2930335362136878 1.0 0.7262079043660925 10 Q6NUK1,Q9Y487,O75844 3 +Corneal ulceration 0.632712788498503 1.0482625863146064 0.2945176421670066 1.0 0.7285523105730818 5 O75844 1 +Peptic ulcer 0.5046586406730528 1.047478807188844 0.2948788015642973 1.0 0.7290379761424747 11 Q15056,P04062,P35250 3 +Limb muscle weakness 0.3471388794087525 1.0407811057405023 0.2979771510108271 1.0 0.7293647718930106 62 Q13501,P04792,O95140,Q13126,Q99720,Q9NR77,P40939,Q969G3,Q15120,Q15067,Q13510,P31483,P37198,Q8N0X7,Q14739 15 +Hypokinesia 0.5355315572309189 1.0383572192702633 0.2991037787584452 1.0 0.7293647718930106 8 O95831 1 +Muscle abnormality related to mitochondrial dysfunction 0.4046060308480467 1.037756906423145 0.2993832441177557 1.0 0.7293647718930106 30 Q8IUX1,O75306,Q8N183,Q9NPL8,P00403,Q9P032,O43676,O75648,P12235,Q9UBX3,Q9Y375 11 +Insulin resistance 0.4542006789624955 1.0368045570566478 0.2998269513424514 1.0 0.7293647718930106 16 P31751,O95140,O75431,O75844 4 +Limb girdle muscular dystrophy 0.5345484633322973 1.0335460312226925 0.3013484405988831 1.0 0.7293647718930106 8 Q13642,O14979 2 +Polycystic kidney dysplasia 0.4738909063097897 1.0327413205313916 0.3017249709074363 1.0 0.7293647718930106 13 Q16134,P23786 2 +Ectopia pupillae 0.6281532577919882 1.028986577253383 0.3034859824049307 1.0 0.731110294214057 5 O96028,Q13363 2 +Ventricular preexcitation 0.6277981807593861 1.0274863787439492 0.3041914961425931 1.0 0.7316575295928321 5 O75306,P10253 2 +Abnormality of the autonomic nervous system 0.3840979939215309 1.0237195396666694 0.3059677634990443 1.0 0.7335258281636907 39 P41440,P06280,P04062,Q15067,O43681,Q9UBM7,Q96EK5,P42892 8 +Myositis 0.5228796583437427 1.023158057810635 0.3062331201094181 1.0 0.7337319015406049 9 Q9NZ08,P28070 2 +Emg neuropathic changes 0.4371115902986187 1.0199435688422438 0.3077552247769008 1.0 0.7357292330550503 19 O95140,P04792,P22626,Q9NR77,Q13510,O43681 6 +Abnormal synaptic transmission at the neuromuscular junction 0.41653897074379 1.0197871441845918 0.30782942153427 1.0 0.7357292330550503 24 O75340,P07737,Q96GM8,Q92804,P35637,Q15165,Q13501 7 +Impaired vibration sensation in the lower limbs 0.4993076547808404 1.0187953816993829 0.3083001187145848 1.0 0.7357292330550503 11 Q9NR77 1 +Dysmetria 0.3740376790991243 1.01857600792747 0.3084042992561964 1.0 0.7357292330550503 44 Q99519,P41440,Q15056,Q8N183,Q9NPL8,Q8IV08,P35250,Q10713,Q96BR5,Q9Y4P3,Q06787,Q5JRX3,O75503,O14773,Q9Y3E5,Q6DKK2,Q8N0X7,Q13501 18 +Basal ganglia gliosis 0.60594872205748 1.0183753299040217 0.308499621582166 1.0 0.7357292330550503 6 O75306 1 +Periauricular skin pits 0.5312428337628999 1.0173726522976778 0.3089761866297209 1.0 0.7360228431038262 8 O96028,Q13363,P61978 3 +Aplasia hypoplasia involving the skeletal musculature 0.5216026728064427 1.0167480955442385 0.3092732795490174 1.0 0.7362302020695931 9 Q9Y487,Q9NR77,Q9Y5S9 3 +Slowly progressive 0.3665680776286613 1.0153877811698864 0.3099210152419074 1.0 0.7373752826331126 47 P41440,O75340,P04792,O00584,Q8IV08,Q99720,Q9NR77,O14979,O95831,Q15120,P31483 11 +Abnormality of subcutaneous fat tissue 0.4849936138710955 1.0148990186694318 0.3101539660422192 1.0 0.7375327912928686 12 Q6NUK1,Q9Y487,O75844 3 +Progressive spastic quadriplegia 0.5669896772825365 1.0125255539429945 0.3112868348139455 1.0 0.7391789410614645 7 Q9Y263,P17900,O43681 3 +Increased circulating antibody level 0.4979494675273402 1.0115162386898704 0.3117694129819088 1.0 0.7391789410614645 11 Q14108,P04062 2 +Gliosis 0.3931614173998875 1.0060107596757262 0.3144103942794582 1.0 0.7424902893481717 33 O75306,P13804,Q16134,P04062,P35637,Q13501 6 +Upper limb spasticity 0.6030700228388941 1.0059886044944368 0.3144210517633112 1.0 0.7424902893481717 6 P35637,Q99720 2 +Calvarial hyperostosis 0.6485191498410751 1.0033665800902205 0.3156840226732522 1.0 0.7433765710673224 4 P09651,P22626 2 +Cerebral hemorrhage 0.4962708104392304 1.0025206066223369 0.3160922191907915 1.0 0.7433765710673224 11 Q02978,P23786,P05067 3 +Difficulty walking 0.3444087132224147 1.0017236716491638 0.3164770706126538 1.0 0.7433765710673224 55 O75340,O43681,P04792,O95140,Q15041,Q99720,P35637,Q9NR77,Q969G3,Q15067,Q15120,Q13510,P31483,Q8N0X7,Q13501 15 +Absence of subcutaneous fat 0.6019257943488793 1.0010674490092266 0.316794200755472 1.0 0.7437265127077775 6 O75844 1 +Abnormal blistering of the skin 0.437519231338482 0.9991703021789048 0.3177121996009773 1.0 0.7446958446397046 18 Q06136 1 +Decreased adipose tissue 0.4679852569364824 0.9983283719326392 0.3181201541203409 1.0 0.7451160174697331 13 P18074,Q6NUK1,O75844 3 +Infantile muscular hypotonia 0.3594594887866287 0.9977577312224284 0.3183968512362187 1.0 0.7451160174697331 49 P17900,O75306,Q9BVA1,P16219,Q969G3,P16278,Q9Y487,Q13510,P10253,P37198,Q99519 11 +Turricephaly 0.5625949542099816 0.9923964888719438 0.3210041510668091 1.0 0.749235546263059 7 Q6NUK1,Q13642,P21964,P07237 4 +Myalgia 0.3846343969407508 0.9917251664874288 0.3213316110240272 1.0 0.749604280358266 36 Q9NZ08,O15460,P06280,P40939,Q14739 5 +Abnormality of the neck 0.3308521154220459 0.9870314499637396 0.3236272210482764 1.0 0.7521824480801507 126 Q9UHX1,P35250,P16278,Q13501,Q14739,P07437,Q99720,O75844,P18074,O95831,Q9BW83,Q9UBM7,Q96EK5,Q15056,O96028,Q14738,P35637,Q03164,Q15555,Q9Y487 20 +Atlantoaxial abnormality 0.7480491585451999 0.9854030604129836 0.3244261269804165 1.0 0.7536432561104949 3 Q9NWM8 1 +Hernia 0.319016597884873 0.9835061483021842 0.3253583908038147 1.0 0.7552926608586517 101 Q9UHX1,P35250,Q6NUK1,P16278,Q14739,Q6ZXV5,P07437,Q969G3,Q9NWM8,Q8WYQ5,Q99519,Q15738,P18074,Q9UBM7,Q15056,O96028,Q15555,Q9Y4P3,Q9Y487 19 +Lymphedema 0.492276231783214 0.9811203408521536 0.3265334007405072 1.0 0.7565517189498498 11 Q14739 1 +Abnormality of the calf 0.3719530469274988 0.9792067395693356 0.3274778392610045 1.0 0.7575602909145058 43 Q9Y619,Q15056,Q13126,O75718,P35250,Q9NR77,Q9Y5S9,Q9Y4P3,P16278,O95831,Q8N0X7 11 +Nonimmune hydrops fetalis 0.419406780510651 0.977996993561596 0.3280758110299699 1.0 0.7575602909145058 22 P10619,P04062,Q14739 3 +Hypoplasia of the musculature 0.5958462058165602 0.9749446424209294 0.3295877201339801 1.0 0.7583673616353491 6 Q9Y487,Q9NR77 2 +Central nervous system cyst 0.369393142107134 0.9747410714842052 0.3296887144135128 1.0 0.7583673616353491 44 Q9UHX1,O96028,P23786,P07437,Q969G3,Q9Y487,Q9UBM7,P37198 8 +Abnormal pleura morphology 0.4333810890774904 0.9718285826780736 0.3311358337659189 1.0 0.7583673616353491 18 Q9NZ08,Q14739 2 +Postaxial hand polydactyly 0.5216369903042585 0.970422069457654 0.331836152433322 1.0 0.7583673616353491 8 Q9BW83,Q9UBM7,Q9UM00,Q14739 4 +Congenital ichthyosiform erythroderma 0.6138765961563301 0.9687932349880256 0.332648362597731 1.0 0.7583673616353491 5 P18074,P04062 2 +Proximal symphalangism 0.7429620563035498 0.9660995416821252 0.3339943738607465 1.0 0.7583673616353491 3 P48651,Q15233 2 +Symphalangism affecting the phalanges of the hand 0.7429620563035498 0.9660995416821252 0.3339943738607465 1.0 0.7583673616353491 3 P48651,Q15233 2 +Synostosis of metacarpals metatarsals 0.7429620563035474 0.9660995416821172 0.3339943738607505 1.0 0.7583673616353491 3 P16435,Q15233 2 +Hyporeflexia of lower limbs 0.5206016428642112 0.965366907937269 0.334361070249165 1.0 0.7583673616353491 8 Q9NR77,P04792 2 +Cachexia 0.4495719398247239 0.9642141638168076 0.3349385646952001 1.0 0.7583673616353491 15 Q01844,Q99720,P04062,P35637 4 +Tachycardia 0.4287467646969805 0.963765248087104 0.3351636334102714 1.0 0.7583673616353491 19 Q8NFF5,O43772,P23786,P42892 4 +Nausea 0.4493916822251609 0.9631067642479608 0.3354939475552192 1.0 0.7583673616353491 15 Q16134,P06280,P13804,O43464 4 +Skeletal muscle hypertrophy 0.3813020511825453 0.9630007968413872 0.3355471233824052 1.0 0.7583673616353491 36 Q15056,P61978,P35250,Q9NR77,Q9Y4P3,P16278,O75648,P10253 8 +Dysgraphia 0.4554867674701031 0.9608736133924982 0.3366157195778261 1.0 0.7602981972385009 14 Q13501,Q15056,P05067,P35250 4 +Neuronal loss in central nervous system 0.5554639080822062 0.9597780539087246 0.3371669297895767 1.0 0.7608619032955601 7 P35637,P04062 2 +Abnormal clavicle morphology 0.4415042520691913 0.956599782081405 0.3387692988712181 1.0 0.76200319399616 16 Q9Y619,Q15738,O75844,Q9Y5S9,O75431,Q14739 6 +Early onset of sexual maturation 0.3790472357162434 0.9540016322760018 0.3400828161444673 1.0 0.7631495467803081 37 Q15056,O75874,O96028,P35250,Q9Y4P3,P48735,Q9UBM7 7 +Left ventricular hypertrophy 0.4198917083733922 0.9535321897375012 0.3403204946369995 1.0 0.7631495467803081 21 P06280,P10253,Q6NUK1,P00403,P78536,P40939,O75880,Q07021,P12235,O75431 10 +Abnormal nephron morphology 0.3575935347964617 0.9521456378556086 0.3410231263854026 1.0 0.7633326356288643 48 Q14108,Q9NZ08,O75306,Q15056,P06280,Q8NFH4,P23786,P35250,Q02978,P00403,Q9Y4P3 11 +Developmental cataract 0.3623706474314152 0.9505224957426468 0.3418468289580172 1.0 0.7638315827660359 46 P48449,P13804,Q16134,P18074,Q99797,Q99519 6 +Abnormal waist to hip ratio 0.5901239221947583 0.9503996817841937 0.3419092056190878 1.0 0.7638315827660359 6 P31751 1 +Abnormal electroretinogram 0.3993570806009982 0.949678077793815 0.3422758521332834 1.0 0.7638315827660359 27 P50897,Q15555,P40939,Q15067,Q9BW83 5 +Cyanosis 0.4471394072919361 0.9492711405813856 0.3424827275032021 1.0 0.7638315827660359 15 O43772 1 +Chorioretinal dysplasia 0.6352030762865426 0.948863213989488 0.3426901860674924 1.0 0.7638315827660359 4 O43505,P53701 2 +Abnormal caudate nucleus morphology 0.5527463893644277 0.947364390582444 0.3434531299124188 1.0 0.7643775241866069 7 O75306,Q9BVA1 2 +Limitation of joint mobility 0.3344272986867266 0.9470996472137644 0.3435880044958379 1.0 0.7643775241866069 76 P16435,P08236,Q03001,P35250,P16278,P15586,P48735,P48651,O75874,P23786,O75844,Q9HC21,P18074,Q96J02,P37268,O75431,O15460,Q15056,O95140,P54802,Q9Y4P3,O14979,P51648,Q13642,Q96AY3 25 +Jaundice 0.3684810602282857 0.9468080863175256 0.3437365805125845 1.0 0.7643775241866069 43 P61916,P13804,Q16134,P00374,O75648,Q00059,Q15904,Q14739 8 +Abnormality of upper limb joint 0.3312142158067646 0.9461433442439648 0.3440754786598665 1.0 0.7644134056746631 82 Q9Y619,P35250,Q9NR77,P16278,P10644,P57081,Q15392,P42892,P48651,P23786,Q13510,Q9Y3E5,O75844,Q13363,P18074,Q9Y5S9,O95831,Q96J02,Q15056,O96028,Q03164,Q9Y4P3,Q13642 23 +Anarthria 0.5886059966498218 0.943896497256688 0.3452225421547736 1.0 0.765746404443334 6 P35637 1 +Impaired proprioception 0.3881131365082387 0.9432284646240328 0.3455640568096076 1.0 0.765746404443334 32 Q9Y619,P41440,O95140,Q8IV08,P54802,Q9NR77,Q13217,Q06787,Q15120,O14773,Q8N0X7 11 +Sparse eyebrow 0.4056502929087577 0.9398852404927136 0.3472764288909986 1.0 0.7680018224924435 24 P48449,P61978,O75844,P14923,Q96EK5,Q9UM00,O60828,Q5SRE5,Q00577,O75431 10 +Fever 0.336316864619871 0.9343428100317036 0.3501270880722142 1.0 0.7681560181936017 68 Q9NZ08,P28070,O15460,P06280,P23786,P18074,Q9NR77,Q13510,P10253,Q14739 10 +Vertebral compression fracture 0.4446796816781077 0.9341640783710232 0.3502192621995776 1.0 0.7681560181936017 15 Q14108,O75718,P04062 3 +Entropion 0.5049138887794143 0.9330994882505832 0.3507686033371899 1.0 0.7681560181936017 9 O75844 1 +Lower limb spasticity 0.3371781800955176 0.9330874151604012 0.3507748363260876 1.0 0.7681560181936017 64 Q9Y619,O75306,P04062,P35637,O95831,Q5XKP0,Q99720,Q6DKK2,Q99519 9 +Foot dorsiflexor weakness 0.400244226075093 0.932815299177056 0.3509153406009391 1.0 0.7681560181936017 25 Q13501,P04792,O95140,Q99720,Q9NR77,Q13642,P31483,Q14739 8 +Dyscalculia 0.5136378711789834 0.931399937089335 0.3516467234092366 1.0 0.7681560181936017 8 P35637,P09651,P22626,Q13501 4 +Degeneration of the lateral corticospinal tracts 0.5856647170216818 0.9313053257044104 0.3516956478754127 1.0 0.7681560181936017 6 P35637 1 +Pulmonary fibrosis 0.4302410598528744 0.9302861032425954 0.3522229710703954 1.0 0.7681560181936017 17 P09601 1 +Nuclear cataract 0.6304478054328528 0.9294788767224708 0.3526409672296342 1.0 0.7681560181936017 4 Q99797 1 +Scrotal hypoplasia 0.4297509447776926 0.9270996621411204 0.3538747915585087 1.0 0.7681560181936017 17 P18074,Q15555,Q9UBM7,P07437 4 +Abnormal morphology of the musculature of the neck 0.4939008279697459 0.9238859406739316 0.3555457037906708 1.0 0.7681560181936017 10 P35637,Q99720 2 +Abnormal peripheral nervous system morphology 0.3250317204955652 0.9216833955730744 0.3566937440899944 1.0 0.7681560181936017 124 Q9Y619,Q9UHX1,P04792,O95721,Q9NR77,Q15120,Q13501,P31930,Q8IV08,Q13510,Q99720,Q99519,P41440,Q9BUF5,P00403,P16219,O95831,Q15067,Q6DKK2,P35637,O43681 21 +Abnormality of bladder morphology 0.4932911687672301 0.9207547889972716 0.3571784641318072 1.0 0.7681560181936017 10 Q9NWM8,Q15056,P35250 3 +Abdominal pain 0.3341775649057926 0.9204622067557648 0.3573312739971372 1.0 0.7681560181936017 71 Q14108,Q9NZ08,O15460,Q15056,P06280,Q8NFH4,P04062,P23786,P35250,Q01844,P35637,Q9Y4P3,P42892,Q70HW3 14 +Neoplasm of the skeletal system 0.3761123988931601 0.9182309771447236 0.3584979542974886 1.0 0.7681560181936017 36 P48735,Q13126,Q92804,O75874 4 +Goiter 0.5820928997486132 0.9160338288777315 0.3596491521029827 1.0 0.7681560181936017 6 P48735 1 +Tongue fasciculations 0.5014692354200798 0.9158738195082412 0.3597330797695846 1.0 0.7681560181936017 9 Q13510 1 +Aplasia hypoplasia of the optic nerve 0.4347037845486722 0.9136490573476148 0.360901280099319 1.0 0.7681560181936017 16 Q9UHX1 1 +Aplasia hypoplasia of the phalanges of the hand 0.3701368876719956 0.9129584290996752 0.3612644055860352 1.0 0.7681560181936017 40 Q9UHX1,O75844,Q14739 3 +Minicore myopathy 0.6778140293637871 0.9124704859404544 0.3615210993327458 1.0 0.7681560181936017 2 P51114 1 +Nocturnal hypoventilation 0.6778140293637746 0.9124704859404028 0.3615210993327729 1.0 0.7681560181936017 2 P61978 1 +Progeroid facial appearance 0.5450073995111905 0.912072445837736 0.3617305821657528 1.0 0.7681560181936017 7 O75844 1 +Beaking of vertebral bodies 0.580879273631651 0.9108499012184827 0.3623744655442662 1.0 0.7681560181936017 6 P16278,Q9UM00,P08236 3 +Abnormal abdomen morphology 0.3489322650824266 0.9101202459727225 0.3627590984029303 1.0 0.7681560181936017 178 Q9Y619,P28070,P21964,Q01844,P31751,P16278,P09601,P40939,O75880,P10644,Q15392,Q15904,Q9Y375,Q14739,O75306,O43772,Q16134,P23786,Q13510,Q99519,Q14108,P61916,P13804,O75340,P00374,P10619,Q9Y5S9,P20674,O43676,Q15067,Q96J02,Q00059,O75431,Q9NZ08,O15118,O95140,P04062,P54802,Q9P032,O75648,P10253,Q8N183 42 +Neck muscle weakness 0.4990945983357848 0.9040094913412832 0.3659903685902477 1.0 0.7723165077646305 9 P35637 1 +Abnormal visual electrophysiology 0.370359129911898 0.9013826699057832 0.3673848924289613 1.0 0.7737825615301409 39 P50897,Q15555,P40939,Q15067,O75503,Q9BW83,O43681 7 +Secondary microcephaly 0.3350442997537007 0.899369060398111 0.3684561134645983 1.0 0.7743211253779669 55 Q9UHX1,P00374,P50897,Q5XKP0,Q9Y487 5 +Proximal upper limb amyotrophy 0.578162889871296 0.8992567243140476 0.3685159323808773 1.0 0.7743211253779669 6 O14979 1 +Abnormality of the musculature of the upper arm 0.578162889871296 0.8992567243140476 0.3685159323808773 1.0 0.7743211253779669 6 O14979 1 +Abnormal cranial nerve morphology 0.3516317566538579 0.8927125351150913 0.372011135803201 1.0 0.776037957839017 48 Q9BUF5,Q9UHX1,O75340,P48651,P22626,Q02978,P09651,P16219,Q969G3,P10644,Q13510,Q9Y3E5,Q13501 13 +Lower limb asymmetry 0.6213186011099607 0.8924011212030578 0.3721779703752543 1.0 0.776037957839017 4 P07437 1 +Corneal dystrophy 0.7230396831095003 0.8910395881759313 0.372907932468524 1.0 0.776037957839017 3 P06280 1 +Abnormality of mouth size 0.3148751973246169 0.8888177980317585 0.3741010090189158 1.0 0.7769701525262928 98 Q9Y619,Q01105,P21964,Q8NCH0,P35250,Q6NUK1,P16278,P15586,P57081,Q15392,P48651,Q96C86,P07437,Q969G3,O75844,O96019,Q92785,Q9UM00,P55011,Q9UBM7,O75431,Q9Y487,Q15056,Q9UQR1,P04062,Q15555,Q9Y4P3,O75648 28 +Visual field defect 0.371558067826207 0.8886926027666723 0.3741683076827953 1.0 0.7769701525262928 37 O75306,O15460,Q9BVA1,Q8WWV3,P00403,Q15555,Q9H061,Q969G3 8 +Partial agenesis of the corpus callosum 0.4743168898980591 0.8850924985412392 0.3761067449778346 1.0 0.7789098468059521 11 P18074,P57081,Q15392 3 +Decreased circulating igg level 0.486265928381522 0.8847146092052272 0.376310574279519 1.0 0.7789098468059521 10 P18074,Q15904 2 +Respiratory failure requiring assisted ventilation 0.6190442833702148 0.8831945415554503 0.3771311702749296 1.0 0.7801923134359278 4 P10253 1 +Red eye 0.4198773759169242 0.8826172807692085 0.3774430885934547 1.0 0.7804725483164331 18 Q9NZ08,P28070,Q14739 3 +Weight loss 0.3332333851059412 0.8810483198592232 0.3782916673671617 1.0 0.7818617031611944 59 Q9NZ08,O15460,Q06136,O75844,P04062,Q01844,P35637,Q99720 8 +Intrinsic hand muscle atrophy 0.5922591560897092 0.878291390266805 0.3797856069450847 1.0 0.782754771443667 5 Q9NR77,Q13501 2 +Postaxial polydactyly 0.4473024811184334 0.8779595564934513 0.379965667036013 1.0 0.7827611296228623 13 P98175,P61978,Q9Y263,Q10713,Q9UM00,Q9BW83,Q9UBM7,Q14739 8 +Rib fusion 0.5726923848013303 0.8759526597511652 0.3810557700723422 1.0 0.7827892828676599 6 O96028,Q9UM00 2 +Abnormal lower limb bone morphology 0.3183176894175951 0.8758739786891504 0.3810985470078458 1.0 0.7827892828676599 118 Q9Y619,Q9UHX1,P21964,P06280,P16435,P08236,Q6NUQ1,Q10713,P16278,P40939,P10644,Q5SRE5,Q15392,Q14739,P98175,Q13510,O00116,Q8N0X7,O75718,O75844,Q13363,O96019,P18074,Q9Y5S9,O95831,P55011,Q9UBM7,O75431,O43505,O75648,P04062,O96028,Q9Y263,Q03164,Q06787,Q9Y487,Q96AY3 37 +Retinal dysplasia 0.5364268841923909 0.8730654468818493 0.3826274061354562 1.0 0.7827892828676599 7 O43505,P07437 2 +Basal ganglia cysts 0.5719394345322573 0.8727499426364905 0.3827993893466042 1.0 0.7827892828676599 6 P23786 1 +Upper limb amyotrophy 0.4406329181932035 0.8721559584163029 0.3831233021395772 1.0 0.7827892828676599 14 Q13501,Q9NR77,P04792,Q15120 4 +Prematurely aged appearance 0.3715242058080225 0.8700760183883431 0.3842588623786354 1.0 0.7827892828676599 35 Q15056,Q13126,O75844,P35250,P18074,Q9Y4P3,Q9Y487 7 +Generalized lipodystrophy 0.6157904316152975 0.8700455001004815 0.3842755394014205 1.0 0.7827892828676599 4 O75844 1 +Spinal muscular atrophy 0.500790851349469 0.8689352454829898 0.384882550171338 1.0 0.7827892828676599 8 Q13510 1 +Diplopia 0.4339312376477708 0.8682127598571429 0.3852778702520687 1.0 0.7827892828676599 15 P18074,O15460,P04062 3 +Progressive cerebellar ataxia 0.3832680856686799 0.8679617654866767 0.3854152640732708 1.0 0.7827892828676599 30 Q9Y619,O75306,P35637,Q9Y487,Q13501 5 +Osteolysis involving bones of the upper limbs 0.5889128104691785 0.8643705259865992 0.3873843787216944 1.0 0.7827892828676599 5 O75844 1 +Abnormality of the ureter 0.3508872772697827 0.8612688157430604 0.3890900066059979 1.0 0.7827892828676599 47 Q9UHX1,Q15056,Q86XL3,O75844,P23786,P35250,Q9UBM7 7 +Weakness due to upper motor neuron dysfunction 0.3099446876592632 0.8600871018533011 0.3897410305816673 1.0 0.7827892828676599 106 Q9Y619,Q8N183,Q13423,P57081,P37198,Q13501,O75306,Q4G0N4,Q969G3,Q13510,Q8N0X7,Q9BVA1,Q15041,P18074,P00403,O95831,Q6DKK2,Q9NZ08,P17900,Q96GM8,P04062,P35637,Q5XKP0,Q9UBX3,O43681 25 +Abnormality of the amniotic fluid 0.3310322371757348 0.8599112160750129 0.3898379853115832 1.0 0.7827892828676599 62 Q70HW3,Q9UHX1,O75844,P04062,P23786,P40939,Q9UBM7,Q14739 8 +Facial asymmetry 0.3873057300578653 0.857304828841643 0.3912764405195703 1.0 0.7827892828676599 27 Q03164,Q9UHX1,O96028,Q14738 4 +Recurrent fever 0.4564303461464847 0.8557325917314514 0.3921457083337851 1.0 0.7827892828676599 12 P28070,Q13510 2 +Abnormal metatarsal morphology 0.4253172836245861 0.8544310963723232 0.3928661722315654 1.0 0.7827892828676599 16 O43505,Q9UBM7,P16435,O96028,P08236,Q13363,P10644,Q15392 8 +Myoclonus 0.3296469757794246 0.851999013131784 0.3942146397905524 1.0 0.7827892828676599 66 Q14108,Q01105,P05067,Q96GM8,P04062,P00374,P50897,P00403,O75503,Q13510,Q9UBX3,P37198,Q99519 13 +Frequent falls 0.3831192782888274 0.8514146282333679 0.3945390686327377 1.0 0.7827892828676599 29 O75340,O95140,P04062,Q9NR77,P40939,Q13510,P37198,O43681 8 +Congenital nonbullous ichthyosiform erythroderma 0.6110664876626064 0.8510058812990966 0.3947660857494046 1.0 0.7827892828676599 4 P04062 1 +Right ventricular cardiomyopathy 0.6110204081632615 0.8508204644050139 0.3948690919106563 1.0 0.7827892828676599 4 Q14126,P15924,P14923 3 +Metaphyseal striations 0.6106192056131077 0.8492063409657719 0.3957664855010423 1.0 0.7827892828676599 4 Q13126 1 +Bowing of the legs 0.3669324734250607 0.8483357134935786 0.3962510335963303 1.0 0.7827892828676599 37 Q9Y619,Q15056,Q13126,O75718,P35250,Q9NR77,Q9Y5S9,Q9Y4P3,P16278,Q8N0X7 10 +Abnormal size of the clitoris 0.4544631565061845 0.8448130319838826 0.3982152372712693 1.0 0.7827892828676599 12 Q9Y619,Q9UBM7,Q96GM8 3 +Eyelid myoclonus 0.4952315582156481 0.8420072055855641 0.3997839201714233 1.0 0.7827892828676599 8 P00374,Q13510 2 +Abnormal liver morphology 0.3465597217556348 0.8415737799905121 0.4000265709226995 1.0 0.7827892828676599 185 Q9Y619,P28070,Q01844,P31751,P09651,P16278,P09601,P40939,O75880,Q15904,Q9Y375,Q14739,O75306,O43772,Q16134,P23786,Q13510,Q99519,Q14108,P61916,P13804,O75340,P00374,P10619,Q16836,P16219,P20674,O43676,Q15067,Q9Y5S9,Q96J02,Q9BW83,Q00059,O75431,O15118,O95140,P04062,P22626,P54802,Q9P032,Q5XKP0,O75648,P10253,Q8N183 44 +Reduced subcutaneous adipose tissue 0.5294126719777905 0.8412938604735198 0.4001833292545771 1.0 0.7827892828676599 7 O75844 1 +Gingival bleeding 0.4777028055894249 0.8409073228792115 0.4003998556967554 1.0 0.7827892828676599 10 Q14108 1 +Elfin facies 0.5285950287664061 0.8375978346956569 0.4022566093535711 1.0 0.7827892828676599 7 Q15056,P35250 2 +Bilateral sensorineural hearing impairment 0.4066539979150794 0.8374719903659348 0.4023273147534278 1.0 0.7827892828676599 20 P18074,P35637,P00403,O43681,Q13501 5 +Malabsorption 0.3528408309584948 0.8372674173723502 0.4024422696083041 1.0 0.7827892828676599 45 Q9NZ08,Q15056,P06280,P35250,P18074,P09601,Q14739 7 +2 3 finger syndactyly 0.6590538336052243 0.8357297396821216 0.4033069606325492 1.0 0.7827892828676599 2 P14923 1 +3 4 finger syndactyly 0.6590538336052243 0.8357297396821216 0.4033069606325492 1.0 0.7827892828676599 2 P14923 1 +Hypovolemic shock 0.6590538336052243 0.8357297396821216 0.4033069606325492 1.0 0.7827892828676599 2 P14923 1 +Shock 0.6590538336052243 0.8357297396821216 0.4033069606325492 1.0 0.7827892828676599 2 P14923 1 +Short palm 0.4223268618486082 0.83559112767028 0.4033849617548792 1.0 0.7827892828676599 16 Q9Y619,Q15555,Q9UHX1,P10644 4 +Renal cyst 0.3480840829956459 0.8336715693770002 0.4044660832900431 1.0 0.7827892828676599 47 Q9UHX1,P13804,Q15056,Q16134,P23786,P35250,Q9BW83,Q9UBM7 8 +Abnormal fear anxiety related behavior 0.316828275829678 0.8301742526011939 0.4064402702831025 1.0 0.7827892828676599 90 P21964,P06280,Q92804,P35250,P09651,P10644,Q13501,P07737,P31930,O43464,Q02978,Q15165,Q9BZH6,O75503,Q8N0X7,O96019,P00403,Q9UM00,P55011,P12235,Q6DKK2,P17900,Q15056,P35637,Q03164,Q9Y4P3,Q06787,O75648 28 +Abnormal brain positron emission tomography 0.6054128813062707 0.8283027300465917 0.4074990771362694 1.0 0.7827892828676599 4 Q13501 1 +Color vision defect 0.438592535369895 0.8274427132574764 0.4079861793216499 1.0 0.7827892828676599 13 Q9H061,O95140,Q8WWV3,O43464 4 +Cortical dysplasia 0.3848061802796627 0.827044294957538 0.408211955736772 1.0 0.7827892828676599 26 Q9BVA1,P07437 2 +Narrow nasal ridge 0.5605695515904192 0.8245457072178958 0.4096295560769296 1.0 0.7829695447399567 6 O75844 1 +Skin dimple 0.4009480910525498 0.8219187358901544 0.4111231488962121 1.0 0.7837464762741763 21 Q15056,P61978,O96028,P35250,Q03164,Q9Y4P3,Q9UM00 7 +Bone fracture 0.5776355091634848 0.8176713628976948 0.4135448666688064 1.0 0.7856997187612246 5 Q13126 1 +Abnormality of the metacarpal bones 0.3786365534896617 0.8161941883471242 0.4143890802254995 1.0 0.7869656083458069 29 P48651,Q96S52,P16435,Q32P28,P08236,Q13363,O96028,Q6NUK1,P16278,P10644,Q9UBM7,Q15233,Q14739 13 +Short digit 0.3065611423219536 0.8130676612840072 0.416179266292592 1.0 0.7889276056896446 106 P48449,Q9UHX1,Q06136,O75844,O95831,Q13510,Q9UBM7,Q14739 8 +Emotional lability 0.3434309662481256 0.8108681214072166 0.4174414090048999 1.0 0.7899556303993303 48 Q8N0X7,O75306,P07737,Q92804,P35637,P09651,Q15165,Q969G3,O43681,Q8N183,Q13501 11 +Duplication involving bones of the feet 0.4355821055018252 0.810020936767372 0.4179281426937447 1.0 0.7899556303993303 13 P21964,O96028,Q13363,Q9Y263,Q9UBM7,Q14739 6 +Abnormal erythrocyte sedimentation rate 0.5220893865125416 0.8082522012555647 0.4189454126238625 1.0 0.7902173260232641 7 O15460 1 +Talipes equinovarus 0.33262157058905 0.8079242273573098 0.4191342033988978 1.0 0.7902173260232641 52 Q9Y619,P21964,P04792,Q8NCH0,P16435,P08236,Q03001,Q6NUQ1,Q9NR77,Q15392,Q6ZXV5,Q9NWM8,Q9Y3E5,Q13363,Q9HC21,Q9Y5S9,Q9UM00,P61978,Q9UQR1,O96028,Q9Y487,Q96AY3 22 +Abnormal odontoid tissue morphology 0.3668260270918092 0.8078299657223436 0.4191884722388468 1.0 0.7902173260232641 34 P21964,Q15056,P35250,P18074,P07237,Q9Y4P3,P16278,P51648,Q9UBM7 9 +Urinary bladder sphincter dysfunction 0.5565556776298145 0.8076063674473092 0.4193172200263624 1.0 0.7902173260232641 6 P09651,Q9NR77,P22626 3 +Abnormal esophagus physiology 0.3389827860729062 0.8058064842177497 0.420354438682776 1.0 0.7911834160959336 171 Q9Y619,Q01105,Q9UHX1,P06280,P35250,Q6NUK1,Q9NR77,P48735,P37198,Q13501,Q14739,O75306,Q6ZXV5,P07737,P05067,O75874,Q13510,Q99720,Q99519,Q14108,Q9BUF5,P61916,Q15067,Q9UBM7,Q15056,P04062,O96028,P35637,Q03164,Q9Y4P3 30 +Respiratory insufficiency 0.3265891372451064 0.8045231279776803 0.4210949177971801 1.0 0.7913923218442069 143 Q9Y619,P06280,Q92804,Q6NUK1,Q9NR77,P40939,Q9Y375,Q13501,Q14739,O75306,O43772,P07737,Q8NFF5,P23786,O43464,Q15165,Q13510,P61916,O95831,O43676,Q15067,Q70HW3,O95140,P35637,Q9Y263,Q9P032,Q5XKP0,O75648,Q13642,P10253 30 +Abnormality of the cerebrospinal fluid 0.3077265232791461 0.80340268024746 0.4217420263743734 1.0 0.7913923218442069 109 Q8N183,P21964,P16435,P08236,P07237,Q6NUK1,Q9NR77,P10644,Q15392,Q9Y375,O75306,O15382,P48651,P23786,O43464,Q969G3,Q99519,Q8IUX1,Q13363,Q9HC21,P18074,P00403,O95831,O43676,P55011,Q9UBM7,O43505,O95140,Q9NPL8,P04062,O96028,Q14738,Q9P032,O43681 34 +Abnormality of the spleen 0.3076456419188772 0.8031578190500019 0.4218835222509338 1.0 0.7913923218442069 99 Q14108,Q9NZ08,P28070,Q99519,P04062,Q15392,P10619,P16278,Q13510,P10253,Q15904,Q14739 12 +Blindness 0.3253799471826135 0.8031138956671348 0.4219089068298982 1.0 0.7913923218442069 66 Q9NZ08,P17900,P50897,P16278,O43676,Q9Y375 6 +Long palm 0.6508972267536665 0.8028009243102194 0.4220898078478754 1.0 0.791396023785991 2 P16435 1 +Papule 0.4289160170416569 0.8024122188000886 0.422314547359254 1.0 0.7914818826143984 14 O75844 1 +Photophobia 0.3681234926726379 0.7983439568169653 0.424670916029241 1.0 0.7935443437251091 33 Q9NZ08,P48449,Q8WWV3,P18074,Q15555,P40939 6 +Abnormal insulin level 0.3859734836974922 0.7954902765594747 0.4263283648376186 1.0 0.7947566591851978 24 O75844,P31751,Q15555,Q16836,P40939 5 +Asymmetric growth 0.5192254307306311 0.7953708371315376 0.426397818730833 1.0 0.7947566591851978 7 Q15555,P07437 2 +Abnormality of the thoracic cavity 0.4684407849682664 0.7937184486202623 0.427359357718879 1.0 0.7952516118660587 10 Q01844,O15460 2 +Aqueductal stenosis 0.5965638284390464 0.7929672381896669 0.4277969107962271 1.0 0.7952516118660587 4 P57081 1 +Abnormal gastrointestinal motility 0.3855176762003747 0.7921507241761202 0.428272796564547 1.0 0.7952516118660587 24 Q01844,P06280,Q9UBM7,P35637 4 +Abnormal metabolic brain imaging by mrs 0.4566195282702143 0.7910127960842631 0.4289365244206782 1.0 0.7954659318711361 11 O75306 1 +Posterior embryotoxon 0.4263881939428741 0.7874077705370304 0.4310431993988297 1.0 0.7984296868094743 14 Q15056,Q9Y4P3,Q8WYQ5,P35250 4 +Dolichocephaly 0.3959622553898059 0.7873513570655919 0.4310762134526396 1.0 0.7984296868094743 21 P61978,O95721,O96028,Q14738,Q03164,Q96J02 6 +Vomiting 0.3203290234378619 0.7831582691085374 0.4335341771721037 1.0 0.801800681394671 77 Q9Y619,O75306,P13804,Q16134,P06280,P22695,P11117,P23786,P00403,Q16836,P40939,O43676,Q9UBM7,Q9Y375 14 +Adducted thumb 0.3953355058996675 0.7830098127039489 0.433621349739103 1.0 0.801800681394671 21 Q15056,Q86XL3,P35250,Q9Y5S9,Q9Y4P3,P42892 6 +Abnormal heart sound 0.5931998531914735 0.7796036152545572 0.4356242272860426 1.0 0.8028503794637025 4 P10253 1 +Recurrent fractures 0.3738688460974546 0.7787643571528905 0.4361185374008134 1.0 0.8028503794637025 29 Q13126,O75718,O75874,P48735,Q13501 5 +Ovoid vertebral bodies 0.5495291859353592 0.7780643640899338 0.4365310697421045 1.0 0.8028503794637025 6 P54802,P16278 2 +Aplasia hypoplasia of fingers 0.3225244752997841 0.7778072298977289 0.4366826650756581 1.0 0.8028503794637025 69 Q9UHX1,O75844,O95831,Q13510,Q9UBM7 5 +Short upper lip 0.5926090868027395 0.7772609130447738 0.4370048507959865 1.0 0.8028503794637025 4 O96028 1 +Abnormal systemic blood pressure 0.3214556656603173 0.7750452960832187 0.4383128944771097 1.0 0.8030894499885072 72 P21964,O43772,Q15056,O43681,P06280,O75844,P04062,P35250,Q02978,Q13423,P00403,P49366,Q9Y4P3,Q96J02,Q9BW83,P42892 16 +Lower extremity joint dislocation 0.3236186033735037 0.7740329065228413 0.4389113318847095 1.0 0.8035202073369497 59 Q15738,Q6ZXV5,Q9UHX1,P21964,Q15056,Q9UBM7,O75844,Q13363,O96028,P35250,Q14738,Q9Y5S9,Q9Y4P3,P55011,Q9Y487,Q13642,Q9Y3E5 17 +Renal duplication 0.5126084963046115 0.7657059521167532 0.4438512846690672 1.0 0.810550880301934 7 Q15056,P35250 2 +Abnormal tricuspid valve physiology 0.4165692075884671 0.762106350868544 0.4459965327332269 1.0 0.8124557925366814 15 Q96AX1,P36543,Q6NUK1,P40939,P10644,Q15233,Q15904,O75431 8 +Sensory neuropathy 0.3731682865320701 0.7604618219900755 0.4469785816258764 1.0 0.8138426539247569 28 O95140,Q8IV08,Q15041,P22626,P00403,O95831,P40939,Q15067 8 +Joint contracture of the hand 0.3677051581527596 0.7594200652897724 0.4476013142247761 1.0 0.8138426539247569 31 Q9Y619,O75844,Q13642,P18074,Q9NR77,P57081,Q15392,P42892 8 +Dysesthesia 0.5868203105359264 0.7543738343750694 0.4506247785725557 1.0 0.8150316860643931 4 Q9NR77,Q06787 2 +Primitive reflex 0.5434461112082073 0.7526140423182375 0.4516818768566377 1.0 0.8157570197374066 6 P17900 1 +Underdeveloped supraorbital ridges 0.4684717472968057 0.7521297480489467 0.4519730358902498 1.0 0.8158026940227696 9 Q6NUK1,P16435,P98175,Q99519 4 +Decreased circulating acth level 0.5854691015709595 0.74905003820942 0.4538270466405754 1.0 0.8176281170229184 4 Q969G3,P10644 2 +Sarcoma 0.3392941978747101 0.7471412370989853 0.4549783105529217 1.0 0.8186749357772398 47 Q13126,Q92804,O75874,Q01844,P48735,Q15392 6 +Iris coloboma 0.372621508841131 0.7449153150870711 0.4563229160759456 1.0 0.8197872696197838 27 O75340,Q9UHX1,O96028,Q9UBM7,Q96EK5 5 +Recurrent gastroenteritis 0.6831013943909203 0.7439490686304413 0.4569072881649416 1.0 0.8199609154999244 3 P78536 1 +Irregular hyperpigmentation 0.3207965276481754 0.7439474995502343 0.4569082374641091 1.0 0.8199609154999244 54 Q06136,O75844,P07437,P18074,Q15555,Q14739 6 +Coxa vara 0.4583402921928752 0.7425493402760882 0.4577545691532885 1.0 0.8199609154999244 10 Q9Y487,O95831 2 +Skin pit 0.4664972848966789 0.7424321315953348 0.4578255576852896 1.0 0.8199609154999244 9 O96028,Q13363,P61978 3 +Abnormal cerebral vascular morphology 0.320709219499703 0.7417770059448183 0.4582224544045772 1.0 0.8199609154999244 56 Q15056,P05067,O95721,P06280,O75844,P04062,P23786,P35250,Q02978,P00403,Q9Y4P3,P10253 12 +Aganglionic megacolon 0.4470220103166927 0.7403553530426299 0.459084402071398 1.0 0.8199609154999244 11 Q9UBM7,P21964,Q96EK5,P42892 4 +Postaxial foot polydactyly 0.5587157751049601 0.7402098811587007 0.4591726528307829 1.0 0.8199609154999244 5 Q14739 1 +Abnormality of the 5th toe 0.5587157751049601 0.7402098811587007 0.4591726528307829 1.0 0.8199609154999244 5 Q14739 1 +Periventricular cysts 0.5404593510038749 0.7401642138108544 0.4592003589629918 1.0 0.8199609154999244 6 O96028 1 +Death in childhood 0.3856227404115109 0.7392891085420253 0.4597314614725543 1.0 0.8202469762376392 22 Q9NPL8,O95721,P18074,Q6NUQ1,Q96IX5,P20674,O60828,O75431 8 +Tetralogy of fallot 0.3630368541080324 0.7381819454416755 0.4604038926662572 1.0 0.8204749402053727 32 Q9UHX1,Q15056,P35250,Q9Y5S9,Q9Y4P3,Q969G3,Q8WYQ5 7 +Joint dislocation 0.3188258919974397 0.7348456606640715 0.4624334952248703 1.0 0.8216947636098542 69 Q9Y619,Q9UHX1,P21964,P35250,P10644,Q6ZXV5,Q9Y3E5,Q15738,O75844,Q13363,P18074,Q9Y5S9,P55011,Q9UBM7,Q15056,O96028,Q14738,Q9Y4P3,Q9Y487,Q13642 20 +Oromandibular dystonia 0.5815562669737824 0.7336746422625515 0.463147056786116 1.0 0.8220302697291296 4 P35637 1 +Premature skin wrinkling 0.4108357318619168 0.7272527044499449 0.4670711651968944 1.0 0.8260119007060631 15 Q9Y487,O75844 2 +Renal agenesis 0.3490875772722014 0.7231861844347137 0.4695655055332837 1.0 0.8272854254295499 40 Q9UBM7,Q9UHX1,Q86XL3,Q15392 4 +Narrow palpebral fissure 0.4323403334196172 0.7227318676714508 0.4698446329693864 1.0 0.8272854254295499 12 Q03164,O75648,Q8WYQ5 3 +Rigidity 0.3490254019200384 0.7226265308203645 0.4699093639133389 1.0 0.8272854254295499 40 Q8NC96,P31930,P04062,P35270,O43464,Q9Y263,P16278,P12235,Q06787,Q15392,P37198,O43681 12 +Abnormal femoral head morphology 0.4202562402646142 0.7217464640736059 0.4704503695601676 1.0 0.827356653902434 13 P16278 1 +Mitochondrial respiratory chain defects 0.5776988736831103 0.7185793913273365 0.4724001150818173 1.0 0.8288082939337081 4 O75306 1 +Abnormality of the breast 0.3152924416527046 0.7178723865142266 0.4728359754332569 1.0 0.829244060008444 76 Q9Y619,O75874,O96028,P07437,P23786,Q6NUK1,P18074,P51809,Q14738,Q15555,Q15067,P48735,Q9UBM7,Q96EK5 14 +Hallux valgus 0.4091836270842297 0.7172320678972456 0.4732309154634937 1.0 0.829349644985487 15 Q15056,P04062,P35250,Q9Y4P3,Q96J02 5 +Duplication of hand bones 0.3455252424892098 0.7171667758725723 0.4732711969123602 1.0 0.829349644985487 42 Q9UHX1,O96028,Q9Y263,Q9UM00,Q15067,Q9BW83,Q9UBM7,Q14739 8 +Lethargy 0.3180845032798877 0.7162540904278898 0.4738344691164105 1.0 0.8300078641195578 64 Q9Y619,O75306,O43772,P23786,Q16836,P16219,P40939,O43676,Q9Y375 9 +Abnormal brain lactate level by mrs 0.5011128767486235 0.7145312697995748 0.4748987273811009 1.0 0.8302280913860116 7 O75306 1 +Intestinal malrotation 0.3849724698053335 0.7113862367832678 0.4768449254105507 1.0 0.8326431524243448 21 P21964,Q9UBM7,O96028,Q13363,P55011,Q15392,Q14739 7 +Ovarian neoplasm 0.396297510062115 0.7104522374731858 0.4774237394485421 1.0 0.8333196095134954 17 Q01844,P48735,O75874 3 +Abnormality of the synovia 0.317388056529918 0.7071276479375145 0.4794871558271107 1.0 0.835010974090852 63 Q15738,Q9UHX1,Q9NQT5,O75718,Q9UBM7,P16435,O75844,P08236,Q13363,O96028,Q14738,Q9Y5S9,P16278,P55011,Q9Y487,Q13642,Q9Y3E5,Q96AY3 18 +Mildly elevated creatine kinase 0.3929952425593457 0.7058221581199836 0.480298740567525 1.0 0.8350476924253785 18 O75340,Q16836,P40939,O75648,P31483,Q13501 6 +Abnormal cardiac ventricular function 0.417259666282055 0.7045874024232758 0.4810670404565456 1.0 0.8355900745385397 13 P10253,O75844 2 +Eeg with spike wave complexes 0.4664554103795246 0.7040709608193988 0.481388583386406 1.0 0.8355900745385397 8 O75503 1 +Short clavicles 0.4981882368545361 0.7015941056217863 0.4829323286035025 1.0 0.8366665450110817 7 Q15738,O75844 2 +Bruising susceptibility 0.3728413090839455 0.6994950751366639 0.4842426897147778 1.0 0.8369735540634483 24 Q9NWM8,Q13126,Q14108,P04062 4 +Renovascular hypertension 0.5302068860859644 0.6976826736001484 0.4853756661136497 1.0 0.8369735540634483 6 Q15056,P35250 2 +Phonophobia 0.5302068860859644 0.6976826736001484 0.4853756661136497 1.0 0.8369735540634483 6 Q15056,P35250 2 +Supravalvular aortic stenosis 0.5302068860859644 0.6976826736001484 0.4853756661136497 1.0 0.8369735540634483 6 Q15056,P35250 2 +Nystagmus induced head nodding 0.5302068860859644 0.6976826736001484 0.4853756661136497 1.0 0.8369735540634483 6 Q15056,P35250 2 +Overfriendliness 0.5302068860859644 0.6976826736001484 0.4853756661136497 1.0 0.8369735540634483 6 Q15056,P35250 2 +Flat cornea 0.5302068860859644 0.6976826736001484 0.4853756661136497 1.0 0.8369735540634483 6 Q15056,P35250 2 +Brittle hair 0.4059539692197562 0.6976752296837031 0.4853803224446631 1.0 0.8369735540634483 15 P18074,Q9Y487,O75844 3 +Bundle branch block 0.4967948496209671 0.6954432082495379 0.486777590324204 1.0 0.8381186607177611 7 P04899,P06280,P14923 3 +Malar prominence 0.6235725938009844 0.6948464441457437 0.4871515385575327 1.0 0.838393484451349 2 Q96MF7 1 +Abnormality of the septum pellucidum 0.3565934826997174 0.6856769634725647 0.4929168366218917 1.0 0.8433931018872831 32 O43505,Q9BVA1,P48651,Q13409,Q96C86,Q13363,O96028,Q14738,Q9BZH6,Q9Y5S9,Q15392 11 +Abnormal pharynx morphology 0.3579471411775999 0.6809781310547657 0.4958853282207949 1.0 0.8471613776441004 31 Q86YV9,O15460,P54802,Q969G3,P16278,P15586,Q13510 7 +Abnormal renal cortex morphology 0.3382212973425765 0.6799277624236347 0.4965502018392198 1.0 0.8479697076196407 44 Q14108,Q9NZ08,P13804,Q16134,P06280,Q8NFH4,Q02978,P00403 8 +Synostosis of joints 0.3651785673379067 0.678947073106415 0.4971713978893326 1.0 0.8482647788461317 26 Q9UHX1,Q15056,O96028,P35250 4 +Narrow mouth 0.3149403101468664 0.6783302674939005 0.4975623117920191 1.0 0.8482647788461317 56 Q9Y619,P21964,Q8NCH0,P16435,Q6NUK1,Q15042,Q15392,P08754,Q96C86,P07437,O75844,O96019,P55011,Q15233,O75431,Q9Y487,O15160,P04062,Q96ST3,Q15555,O60828,O75648 22 +Broad nasal tip 0.3451003178070677 0.6763678609081233 0.4988071172425412 1.0 0.8482647788461317 39 Q9UHX1,O95831,P16278 3 +Hypoplastic fingernail 0.412279389183856 0.6761582685318632 0.4989401648957683 1.0 0.8482647788461317 13 P48651,Q969G3,O75431,Q14739 4 +Irregular menstruation 0.5426491173362985 0.6755106200084734 0.4993514064178437 1.0 0.8482647788461317 5 Q06787,P10644 2 +Titubation 0.4527513308421366 0.6753571560415504 0.4994488787899243 1.0 0.8482647788461317 9 P35637,Q99720 2 +Temporal optic disc pallor 0.6182707993474773 0.6743831640267335 0.500067743610112 1.0 0.8482647788461317 2 O60313 1 +Morning glory anomaly 0.6182707993474773 0.6743831640267335 0.500067743610112 1.0 0.8482647788461317 2 O60313 1 +Neoplasm of the nervous system 0.3507918036131113 0.6731908087513664 0.5008259078341037 1.0 0.8482647788461317 34 O75874,P07437,Q01844,Q02978,Q15555,P48735 6 +Hammertoe 0.4062258683413866 0.6685233868409197 0.5037995585377981 1.0 0.8508230039758232 14 O95140,Q99720,Q9NR77,Q9UBM7,Q8N0X7 5 +Undetectable light and dark adapted electroretinogram 0.6615809887567619 0.667196446967647 0.5046466603539899 1.0 0.8516250171755142 3 Q15555 1 +Abnormal pulmonary thoracic imaging finding 0.3894439386889031 0.6664771548188506 0.5051061611056533 1.0 0.8516250171755142 17 Q9NZ08,Q13510 2 +Focal segmental glomerulosclerosis 0.3841966224185977 0.6657604614230874 0.5055642208539286 1.0 0.8516250171755142 19 Q14108,P00403,Q8NFH4 3 +Aplasia hypoplasia affecting the eye 0.3118356926018423 0.6650183997457424 0.5060387245703089 1.0 0.8516250171755142 73 Q86YV9,O43505,Q9UHX1,Q15056,O95721,P61978,O96028,P07437,P35250,Q6NUK1,Q02978,P18074,Q15555,Q9Y4P3,Q9UBM7,Q99519 16 +Supranuclear gaze palsy 0.3891766297226682 0.6647664213933606 0.5061999028158324 1.0 0.8516250171755142 17 P35637,Q99720,P04062,Q13501 4 +Atrophic scars 0.5397310783750263 0.6638849716907602 0.50676393553079 1.0 0.8519699447687625 5 Q8NCH0,Q9NWM8 2 +Abnormality of the palm 0.3038699734176189 0.6630595908025304 0.5072923895821744 1.0 0.8519699447687625 90 Q9Y619,P10644,Q9UHX1,Q06136,O95721,P61978,O96028,Q6NUK1,Q9Y263,Q15555,O95831,Q96J02,Q9Y487,Q13642,O75431,Q14739 16 +Abnormality of adrenal morphology 0.3744090477256045 0.6606287476218619 0.5088504283682607 1.0 0.8519699447687625 22 P48735,O75874 2 +Diminished movement 0.4042448483592058 0.6569384535981065 0.5112204913896214 1.0 0.8519699447687625 14 O95831 1 +Bowel diverticulosis 0.4562431754555313 0.6559050836055205 0.5118851971191678 1.0 0.8527563942968284 8 Q15056,P35250 2 +Abnormal renal physiology 0.3064769336250214 0.6550366547755015 0.5124441545040634 1.0 0.8530449737943067 125 O95721,P06280,P35250,P09601,Q9Y375,O75306,O43772,Q16134,P23786,Q14108,P13804,P00403,O43676,Q9BW83,Q9NZ08,O15460,Q15056,P04062,P51809 19 +Abnormal circulating aromatic amino acid concentration 0.6580290792623913 0.654735649456466 0.5126379684475899 1.0 0.8530465517094395 3 P35270 1 +Megaloblastic anemia 0.4558983704894248 0.6542878018742249 0.5129264031713001 1.0 0.8532055213338324 8 P00374 1 +Congenital hypothyroidism 0.5591514655228885 0.646954389674515 0.5176614630338063 1.0 0.85706021834552 4 Q9Y263,Q13423 2 +Gangrene 0.4391455716935218 0.6464258229651088 0.5180036213747603 1.0 0.85706021834552 10 Q9NZ08 1 +Aplasia hypoplasia of the nipples 0.4287806853168618 0.6450941425019677 0.5188661795156944 1.0 0.85706021834552 11 O96028,P07437 2 +Aortic arch aneurysm 0.4848613345806357 0.643130819406919 0.5201392180677837 1.0 0.8584237916096297 7 Q15056,P35250 2 +Sparse lateral eyebrow 0.5579694279151884 0.6424483017906043 0.5205821463051554 1.0 0.8588343279029104 4 Q00577,P61978 2 +Distal lower limb amyotrophy 0.417513910976065 0.6419699735092403 0.5208926791360564 1.0 0.858979735149457 12 Q9NR77,P04792 2 +Abnormal skin morphology of the palm 0.3095288233533106 0.6411270552360275 0.5214401374870419 1.0 0.858979735149457 74 Q9UHX1,Q06136,O95721,P61978,O96028,Q6NUK1,Q96J02,Q9Y487,O75431,Q14739 10 +Macrogyria 0.5574799272002415 0.6405844678632524 0.5217926935716346 1.0 0.858979735149457 4 Q15392 1 +Ocular anterior segment dysgenesis 0.3104995972134926 0.6405371098699524 0.5218234711116492 1.0 0.858979735149457 70 P48449,P13804,Q15056,Q16134,O96028,P35250,P18074,P00403,Q99797,Q99519 10 +Erythema 0.379909244973432 0.6374113153315508 0.5238569598076073 1.0 0.8592022720284566 19 Q15738,P00403,Q06136,P18074 4 +Agenesis of corpus callosum 0.3107031371114408 0.6365436698349104 0.5244221270451019 1.0 0.8592022720284566 67 O43505,Q9UHX1,Q9BVA1,P61978,P48651,Q13409,Q86XL3,Q13363,P23786,Q9HC21,P18074,Q92785,P00403,O96028,Q969G3,P55011,P57081,Q15392 18 +Ovotestis 0.6080750407830278 0.6355360736433142 0.5250788472287855 1.0 0.8592022720284566 2 P53701 1 +Abnormal metacarpal morphology 0.3672685022206904 0.6337630625717118 0.526235462422989 1.0 0.8592703198069783 23 P16278 1 +Hypocalcemia 0.4265171105097378 0.6333879298777333 0.5264803451677393 1.0 0.8592703198069783 11 P21964,P40939,Q8WYQ5 3 +Peripheral pulmonary artery stenosis 0.4493114438747771 0.6235159293852696 0.5329455377069863 1.0 0.8633649134521284 8 Q15056,P35250 2 +Premature birth 0.3468539477171941 0.6226173077947138 0.5335360347596674 1.0 0.8633649134521284 33 Q9UBM7,O75844,O43676 3 +Psychomotor retardation 0.3522990660714734 0.6222835242308031 0.5337554528844259 1.0 0.8633649134521284 30 Q9Y619,P04062,O95831,P16278,Q99519 5 +Dermal translucency 0.5114919433602704 0.6213143570203024 0.5343928091710861 1.0 0.8633649134521284 6 O75844 1 +Decreased specific antibody response to vaccination 0.6483068135454995 0.6209607671148458 0.5346254371431516 1.0 0.8633649134521284 3 P50851,P17812 2 +Hypohidrosis 0.479473487995149 0.6197477779385255 0.5354238548349028 1.0 0.8633649134521284 7 Q9H4L7,P06280,P04080 3 +Ectropion 0.4336688557372535 0.6193350726609953 0.5356956439840272 1.0 0.8633649134521284 10 P18074,P04062 2 +Aplasia hypoplasia of the nails 0.3172790858185652 0.6189970482700168 0.5359183034163431 1.0 0.8633649134521284 51 Q15056,O75844,P23786,P35250,Q6NUK1,P18074,Q14738,Q9Y4P3,Q969G3,Q9Y487,Q14739 11 +Contractures of the joints of the upper limbs 0.3196448880050368 0.6184924921935148 0.5362507453076084 1.0 0.8633649134521284 50 Q9Y619,P48651,O75844,Q99720,P23786,Q13642,P18074,P35637,Q9NR77,Q9Y3E5,P37268,P57081,Q15392,Q96AY3,P42892 15 +Abnormality of the knee 0.3093427941855871 0.6180606038375388 0.5365353903154171 1.0 0.8633649134521284 65 Q9Y619,Q6ZXV5,O75340,Q15056,Q86XL3,Q15041,P23786,P35250,Q9NR77,Q9Y5S9,Q9Y4P3,P16278,O95831,Q13510,Q8N0X7 15 +Developmental regression 0.2923691660955492 0.6176973853660792 0.5367748358363456 1.0 0.8633649134521284 101 Q9NZ08,P17900,O75306,Q15056,P06280,P35250,P18074,O95831,P16278,Q15067,O75503,Q13510,O43681,Q99519 14 +Proximal muscle weakness 0.3297505265359471 0.6163003244955048 0.5376963247388304 1.0 0.8633649134521284 45 O75340,O95140,Q8NFF5,Q13126,P10253,P22626,Q13642,P35637,Q13510,Q99720,Q13501 11 +Weakness of facial musculature 0.3356128936832499 0.613457249513955 0.5395740417496282 1.0 0.8647335467859162 41 Q9BUF5,Q9UHX1,P16219,Q969G3,Q13510,Q13501 6 +Bird like facies 0.509419075514328 0.6129627510445392 0.5399009695801003 1.0 0.8647335467859162 6 O75844 1 +Corneal erosion 0.5492542559086855 0.6094645914050201 0.5422165358460214 1.0 0.8666827016714553 4 Q96EK5 1 +Sparse and thin eyebrow 0.4314239798858396 0.6082810546234938 0.5430010840850175 1.0 0.8666827016714553 10 P48449,Q96EK5 2 +Abnormality of the phalanges of the toes 0.5080259712464811 0.6073630310308559 0.5436100168733733 1.0 0.8666827016714553 6 O75844 1 +Muscle stiffness 0.4001155682593856 0.6072717477392067 0.5436705844195102 1.0 0.8666827016714553 13 Q15392 1 +Neuronal loss in the cerebral cortex 0.5252893534256797 0.6069949615973297 0.5438542558297415 1.0 0.8666827016714553 5 P35637 1 +Craniofacial dysostosis 0.5484190979954767 0.6063268239855046 0.5442977497416264 1.0 0.8668374423405033 4 Q6NUK1,P10644 2 +Flat face 0.379671445805341 0.6041882026392591 0.5457185234504385 1.0 0.8676345969609428 17 P07437,Q03164,Q15555,Q9UM00,Q9Y487 5 +Skeletal muscle atrophy 0.3055367240406875 0.6033456889561435 0.54627874440595 1.0 0.8679386852268138 130 P04792,Q92804,Q9NR77,P16278,Q15120,Q13501,P07737,Q15165,Q9NWM8,Q13510,Q99720,Q99519,Q9BVA1,Q13126,O95831,Q9BW83,Q6DKK2,Q96GM8,P35637,O14979 20 +Dental crowding 0.3745085644353564 0.6018491970023001 0.5472745237584551 1.0 0.8685862412493948 19 Q15738,Q01105,P08754,O75844,Q96A33,Q9UBM7,Q15233,O75431 8 +Recurrent tonsillitis 0.5986949429037589 0.6004299353308697 0.5482197424028175 1.0 0.8685862412493948 2 Q13546 1 +Serositis 0.3742470614389045 0.6001318758475469 0.5484183504235638 1.0 0.8685862412493948 19 Q9NZ08,O15460 2 +Poor head control 0.3075894395727838 0.5999772924034281 0.5485213690629402 1.0 0.8685862412493948 54 Q8IUX1,O75306,Q8NC96,O75340,Q9Y3C8,P17900,O95721,Q9NPL8,Q9NQT5,P61981,Q8N183,P00374,O43676,Q5XKP0,Q9NWM8,Q9P032,Q9Y375 17 +Action tremor 0.3309688209177621 0.5968118393136991 0.5506330125598575 1.0 0.869984347767157 43 Q14108,P41440,O75306,P18074,P35637,Q9NR77,Q99720,O43681 8 +Arterial stenosis 0.4193731838374432 0.596640394663621 0.5507474957603526 1.0 0.869984347767157 11 Q15056,P35250 2 +Abnormal morphology of myocardial trabeculae 0.5456885680267833 0.5960972178945696 0.5511102826465051 1.0 0.8702466191165626 4 P14923,Q99797 2 +Tapered finger 0.3485744064554121 0.5930000029822541 0.553181150259447 1.0 0.8713391123922842 30 Q06136,P23786,Q03164,Q15555,Q96EK5 5 +Hypoplasia of the frontal lobes 0.4722216615733016 0.5885340425913013 0.5561738908501348 1.0 0.8738852334004737 7 Q9UBM7 1 +Aplasia hypoplasia of the uterus 0.3748154237748017 0.5877982470440939 0.5566677207949526 1.0 0.8740295807866792 18 Q96GM8,Q16740,O96028,Q9BZH6,Q9Y5S9 5 +Abnormal gallbladder morphology 0.3606517183239062 0.5868888517447303 0.557278357550766 1.0 0.8743044262837688 23 Q15056,P04062,O43681,P35250 4 +Abnormal leukocyte physiology 0.3111185270801002 0.5807842590353045 0.5613858652824137 1.0 0.8785621373228347 52 Q14108,P28070,P21964,P04062,P18074,Q9Y5S9,P09601,Q8WYQ5,P17812,Q15904,Q96J02 11 +Heterotropia 0.3367393040568719 0.579452666977194 0.5622837758065491 1.0 0.8785621373228347 36 P18074,Q9UHX1,P04062,P40939 4 +Diminished motivation 0.3592581811740929 0.5770537625891561 0.563903137776063 1.0 0.8796726032415724 23 P35637,P17900,P04062 3 +Brisk reflexes 0.3678812998398686 0.5754115689644949 0.5650129817637763 1.0 0.8796726032415724 20 P35637,O15382,P20674,Q99720 4 +Abnormal urine metabolite level 0.3029542478637401 0.574777321992708 0.5654419059792934 1.0 0.8796726032415724 129 Q9Y619,O95721,P06280,P35250,P16278,P09601,P40939,Q16134,Q8NFH4,P23786,O43464,Q99519,Q14108,P13804,P18074,P00403,Q16836,Q15056,P04062,Q9Y4P3,Q5XKP0,P10253 22 +Distal upper limb amyotrophy 0.4045405665090937 0.5723047181796933 0.5671155538472128 1.0 0.8796726032415724 12 Q13501,Q9NR77,Q15120 3 +Abnormal motor nerve conduction velocity 0.3896148300141135 0.5720973403636583 0.5672560308740082 1.0 0.8796726032415724 14 O95140,P04792,P31930,Q9NR77,Q99720 5 +Abnormal circulating glutamine family amino acid concentration 0.5384571170299219 0.569229770835854 0.5692002196066712 1.0 0.8808861341218708 4 P20674 1 +Gowers sign 0.4369077006449843 0.566274959070321 0.5712068802628305 1.0 0.8826830754236211 8 Q13510 1 +Abnormality of the coagulation cascade 0.3434123090575715 0.5649656102837437 0.5720971554630585 1.0 0.8826830754236211 31 Q9Y619,Q16836,P40939,Q5XKP0,Q9Y487 5 +Abnormality of the nasal tip 0.3026637138328891 0.5629434288246742 0.5734734063314502 1.0 0.8826830754236211 75 O75431,Q9UHX1,P21964,P61978,P38159,Q13409,O75844,P23786,Q03164,P16278,Q969G3,O95831,Q9Y487,Q96EK5,Q8WYQ5,P42892 16 +Esodeviation 0.3484935289158083 0.5618875234323041 0.5741926548202803 1.0 0.8826830754236211 27 P18074,Q9UHX1,P04062,Q14738 4 +Ulnar deviation of finger 0.5136072692275316 0.5618545808303176 0.5742151011209788 1.0 0.8826830754236211 5 Q9UBM7 1 +Abnormal exteroceptive sensation 0.3284351214113156 0.5603089708492451 0.5752687095185256 1.0 0.8826830754236211 42 Q9NZ08,O15460,P04792,P06280,Q9NR77,O95831 6 +Abdominal distention 0.3827368724074168 0.5587115744989577 0.5763585787570853 1.0 0.8826830754236211 15 Q01844,P04062,O43681 3 +Spotty hyperpigmentation 0.5872756933115899 0.5585876281187587 0.5764431854192691 1.0 0.8826830754236211 2 P54132 1 +Constitutional symptom 0.3275637034353418 0.5584410270917651 0.5765432638628722 1.0 0.8826830754236211 187 P28070,P21964,P06280,Q92804,P35250,Q01844,P09651,Q9NR77,Q13423,P40939,P48735,P42892,Q14739,Q13501,P07737,O75874,Q8NFH4,P23786,Q02978,Q15165,Q969G3,Q13510,Q99720,Q14108,Q15738,O75844,P18074,Q70HW3,Q9NZ08,O15460,Q15056,O95140,P04062,P22626,P35637,Q9Y4P3,P04899,Q13642,O43681 39 +Abnormality of the bladder 0.2963268986912938 0.5583069340680398 0.5766348107859862 1.0 0.8826830754236211 89 Q9UHX1,Q15056,Q86XL3,P04062,P22626,P35250,P35637,Q9NR77,Q9NWM8,Q99720,O43681,Q13501 12 +Venous insufficiency 0.5352960622081774 0.5575920438559759 0.5771229905944311 1.0 0.8826830754236211 4 P04062 1 +Varicose veins 0.5352960622081774 0.5575920438559759 0.5771229905944311 1.0 0.8826830754236211 4 P04062 1 +Spina bifida 0.3492596526323661 0.5536782308604092 0.579799076095187 1.0 0.8826830754236211 25 Q9UHX1,Q15056,P35250,Q9Y5S9,Q9Y4P3 5 +Retinal degeneration 0.315412431611177 0.5528423426804239 0.5803713713299052 1.0 0.8826830754236211 49 Q9UG56,P50897,O75503,Q13510,P68371 5 +Deep plantar creases 0.5112166150497918 0.5527241286569775 0.580452328539117 1.0 0.8826830754236211 5 Q9Y487 1 +Peripheral demyelination 0.4008543998665394 0.5527191088215689 0.5804557664197947 1.0 0.8826830754236211 12 Q9NR77,O43681 2 +Abnormality of the pulmonary veins 0.4942657700808809 0.5526587653874749 0.5804970939248868 1.0 0.8826830754236211 6 Q15392 1 +Skeletal dysplasia 0.3381945363413604 0.5517233033010909 0.5811379415857076 1.0 0.8826830754236211 33 P10619,P16278,Q14739 3 +Pulmonary artery stenosis 0.4263114275453179 0.549130264249012 0.5829160572658945 1.0 0.8834973051481434 9 Q15056,P35250 2 +Abnormality of the lymph nodes 0.3357940392927406 0.5482943712011574 0.5834897917367194 1.0 0.8834973051481434 34 Q9NZ08,P28070,Q13510,O15460 4 +Abnormality of the plantar skin of foot 0.332920751023937 0.5469593330246751 0.5844066713476308 1.0 0.8834973051481434 36 Q06136,P61978,O95721,Q9Y487,O75431 5 +Abnormal activity of mitochondrial respiratory chain 0.3240454417888649 0.5466912945736381 0.5845908359853198 1.0 0.8834973051481434 44 P13073,Q8IUX1,O75306,Q8N183,Q9NPL8,Q16795,P52815,P20674,Q9Y2R0,O43676,O75648,Q9H0R6,Q9P032,Q9UBX3,Q9Y375,Q70HW3 16 +Abnormal choroid morphology 0.3682075852089775 0.5454133299526761 0.5854692745623351 1.0 0.8834973051481434 18 Q9Y619,Q5XKP0 2 +Abnormal chorioretinal morphology 0.3682075852089775 0.5454133299526761 0.5854692745623351 1.0 0.8834973051481434 18 Q9Y619,Q5XKP0 2 +Saccadic smooth pursuit 0.5315484767887889 0.5438829028402605 0.5865220549453434 1.0 0.8839562287886829 4 Q10713,Q06787 2 +Abnormal mitochondrial morphology 0.4315987843289377 0.5420922621016702 0.5877549490129095 1.0 0.8839562287886829 8 P35637 1 +Bone spicule pigmentation of the retina 0.4915086133762771 0.5418393372286109 0.5879291897137888 1.0 0.8839562287886829 6 Q9UG56 1 +Joint hypermobility 0.301057914790162 0.5406797272975393 0.5887283540710677 1.0 0.8843247493899437 74 Q9Y619,Q01105,Q6ZXV5,Q9UHX1,Q15738,Q15056,Q9Y487,P35250,P07237,O96019,Q9Y263,Q03164,Q9Y4P3,Q9UM00,Q9NWM8,O75648,Q15904,Q8N0X7 18 +Cupped ear 0.4174268166673636 0.5401019580702768 0.5891267204110857 1.0 0.8843247493899437 10 P08754,P63241,Q96ST3,Q15392,P42892 5 +Plantar hyperkeratosis 0.3431704507647518 0.5397707765765698 0.5893551229395833 1.0 0.8843247493899437 29 Q06136 1 +Abnormal nipple morphology 0.328539718277807 0.5392154514540791 0.5897381999255507 1.0 0.8843247493899437 40 O96028,P23786,P07437,Q6NUK1,P18074,Q14738,Q15555,Q9UM00,Q15067,Q9UBM7,Q96EK5 11 +Abnormality of circulating adrenocorticotropin level 0.4597828429302155 0.5357666447407889 0.5921198374165921 1.0 0.8868764107326742 7 Q13423,P16435,Q969G3,P10644 4 +Abnormality of the urethra 0.285371152603057 0.532463212855062 0.5944052140451088 1.0 0.8886531848495548 102 Q9Y619,P48449,Q9UHX1,Q15056,O75844,O96028,P07437,P35250,P51809,Q15555,Q9Y4P3,Q9UBM7,Q96EK5 13 +Hyperammonemia 0.3392573818386387 0.5320705736165875 0.5946771171693437 1.0 0.8886531848495548 31 Q9Y619,O43772,P23786,Q16836,P40939 5 +Small nail 0.3304119904414199 0.5314950122963166 0.5950757967115381 1.0 0.8886531848495548 37 Q15056,P23786,P35250,Q6NUK1,P18074,Q14738,Q9Y4P3,Q969G3,Q14739 9 +Focal white matter lesions 0.5054348825342297 0.5308035140468842 0.5955549446904538 1.0 0.8886531848495548 5 O00584 1 +Gonadal neoplasm 0.3607358266338369 0.5280179450184921 0.5974868809163811 1.0 0.8893259118959458 20 Q01844,P48735,O75874 3 +Hyperpituitarism 0.3725077906913947 0.5265563411946442 0.5985017169535745 1.0 0.8893259118959458 16 P16435,P51809,Q969G3,Q06787,P10644,P82650,Q15031 7 +Abnormality of the ovary 0.310612199912155 0.5264354900784101 0.5985856625574324 1.0 0.8893259118959458 50 Q15056,O75874,O75844,P51809,P35250,Q01844,Q9Y4P3,P48735,Q9BW83 9 +Hyperlordosis 0.3289873444477871 0.5260812654058548 0.5988317448699156 1.0 0.8893259118959458 38 Q15738,O75340,Q15056,O95140,P22626,P35250,Q9Y4P3,P16278,Q96J02,Q13642 10 +Abnormal atrioventricular valve morphology 0.3453310891283705 0.5249956367618932 0.5995862241179539 1.0 0.8893259118959458 25 Q15056,P04062,O75844,P35250,Q9Y4P3,O75431 6 +Hip dislocation 0.3165198813507419 0.5241041166575806 0.6002061254508775 1.0 0.8893506508774643 47 Q15738,Q9UHX1,Q9UBM7,O75844,Q13363,O96028,Q14738,Q9Y5S9,P55011,Q9Y487,Q13642,Q9Y3E5 12 +Lower limb amyotrophy 0.3761644894610961 0.5200444835055436 0.6030325711152806 1.0 0.89174625945934 15 Q9NR77,P04792 2 +Hydrocephalus 0.3002580335659301 0.5175230483540222 0.604791083823847 1.0 0.8934505556956831 56 P21964,P16435,P08236,P07237,Q6NUK1,P10644,Q15392,P48651,P23786,Q969G3,Q99519,Q13363,P18074,Q9UBM7,O43505,O95140,O96028,P04062,Q14738 19 +Abnormal dermatoglyphics 0.3000761024955385 0.5143671220029076 0.6069953413821223 1.0 0.895809274251961 57 Q9UHX1,Q15056,P61978,O96028,P35250,Q6NUK1,Q9Y4P3,Q96J02,Q9Y487,Q9UBM7,O75431 11 +Abnormal toenail morphology 0.3249138004961028 0.5070605391647747 0.6121123417167289 1.0 0.9012559545316552 40 Q15056,O75844,P23786,P35250,Q14738,Q9Y4P3,Q14739 7 +Abnormal shoulder morphology 0.3416377715272062 0.5037687752688602 0.614423872271652 1.0 0.9034563786760362 26 Q9Y619,Q6ZXV5,Q15056,O96019,P35250,Q9Y4P3,O75648 7 +Horizontal eyebrow 0.5200691508647168 0.5025184781063053 0.6153028577494375 1.0 0.904051563904656 4 P11233 1 +Generalized abnormality of skin 0.3196477395919923 0.5021159189653698 0.6155859829992001 1.0 0.904051563904656 176 Q86YV9,Q06136,P06280,P35250,P16278,Q15904,Q14739,O75306,O43772,Q16134,Q9NWM8,Q99519,Q14108,P61916,P13804,Q13126,O75844,P18074,P00374,P10619,P00403,Q9UBM7,Q15056,O75648,P04062,Q9Y4P3,Q9Y487 27 +Hyperconvex fingernails 0.481247047049297 0.5020302564881918 0.6156462379563246 1.0 0.904051563904656 6 P48651,O96028 2 +Abnormality of urine homeostasis 0.3127790795836182 0.4981184970795811 0.6184005239111958 1.0 0.9069777082385884 160 Q9Y619,O95721,P06280,P35250,P16278,P09601,P40939,P48735,O43772,Q16134,Q8NFF5,Q8NFH4,P23786,O43464,Q99519,Q14108,P13804,P18074,P00403,Q16836,P16219,O15460,Q15056,P04062,Q9Y4P3,Q5XKP0,P10253 27 +3 methylglutaconic aciduria 0.4086371351454245 0.4980353335131212 0.6184591381522908 1.0 0.9069777082385884 10 Q5XKP0 1 +Coloboma 0.3275969112012578 0.4974074149260822 0.6189017777418844 1.0 0.9073260069447644 35 O43505,O75340,Q9UHX1,O96028,Q9UBM7,Q96EK5 6 +Hypoplasia of teeth 0.3672902294283988 0.4950945762669871 0.6205333621641622 1.0 0.907686350864358 16 P18074,P51648,O75844,O75431 4 +Erythroderma 0.44995070795462 0.4948377788218264 0.6207146344984571 1.0 0.907686350864358 7 P48449 1 +Overriding aorta 0.4143548544216316 0.4936342802932847 0.6215644863226961 1.0 0.907686350864358 9 Q15056,P35250 2 +Demyelinating peripheral neuropathy 0.379418838910441 0.4924077976604535 0.6224310879881525 1.0 0.907686350864358 13 P41440,Q9NR77 2 +Retinal arteriolar tortuosity 0.4139243784386415 0.4916583159019446 0.6229609106467677 1.0 0.9078447714640764 9 Q15056,Q9Y4P3,P35250 3 +Abnormality of the pituitary gland 0.297971296458541 0.4913637950685388 0.6231691663834971 1.0 0.9078447714640764 57 P48735,Q9UHX1,O75874 3 +Depletion of mitochondrial dna in muscle tissue 0.6090173236560441 0.4902272924141127 0.6239730700566799 1.0 0.90843742227146 3 Q9UBX3 1 +Abnormality of skeletal muscle fiber size 0.3707395508142138 0.4884116852070518 0.6252582666826212 1.0 0.909641170872327 15 Q13642,O95831,P22626,Q13501 4 +Abnormality of the scrotum 0.3214783366877547 0.4862381600044834 0.6267983185160473 1.0 0.909641170872327 41 Q9Y619,Q96GM8,P51809,P07437,O96019,Q6NUK1,P18074,Q15555,O75648,Q9UBM7,Q96EK5 11 +Abnormality iris morphology 0.2976162689878673 0.4855524579185132 0.6272845110778573 1.0 0.909641170872327 59 Q86YV9,O75340,Q9UHX1,Q15056,O96028,P35250,Q02978,Q9NR77,Q9Y4P3,Q9UBM7,Q96EK5 11 +Abnormal uvea morphology 0.2954958257719189 0.4842472804754747 0.6282103857976404 1.0 0.909641170872327 77 Q9Y619,Q86YV9,O75340,Q9UHX1,Q15056,O96028,P35250,Q02978,Q9NR77,Q9Y4P3,P40939,Q5XKP0,Q9UBM7,Q96EK5 14 +Agenesis of incisor 0.5660685154975618 0.4838043427963816 0.6285247327214272 1.0 0.909641170872327 2 P54132 1 +Decreased pulmonary function 0.606816970810764 0.4832169481177009 0.6289417027410484 1.0 0.909641170872327 3 Q969G3 1 +Abnormality of muscle size 0.3094727958377886 0.483074022944735 0.6290431780080517 1.0 0.909641170872327 155 P04792,Q92804,P35250,Q9NR77,P16278,Q15120,Q13501,P07737,Q15165,Q9NWM8,Q13510,Q99720,Q99519,Q9BVA1,Q13126,O95831,Q9BW83,Q6DKK2,Q15056,Q96GM8,P22626,P35637,Q9Y4P3,O14979,Q9Y487,P10253 26 +Oligohydramnios 0.3512991931961338 0.4824962303181022 0.6294534756795382 1.0 0.909641170872327 21 Q9UHX1,P16435,P14923,P23786,Q6NUK1,P49366,Q07021 7 +Recurrent otitis media 0.3579339421977628 0.480237849242119 0.6310582764031387 1.0 0.909641170872327 18 Q14739 1 +Subcutaneous hemorrhage 0.3310773941028906 0.4800802991568992 0.6311702962082935 1.0 0.909641170872327 32 Q14108,Q13126,P04062,Q9NWM8,Q99519 5 +Abnormal acetabulum morphology 0.3731810365363971 0.4786989321322386 0.6321528256110245 1.0 0.909641170872327 14 P16278 1 +Increased circulating gonadotropin level 0.4109524442330811 0.4780614008733042 0.6326065038181714 1.0 0.909641170872327 9 P82650,Q06787,P16435,P51809 4 +Abnormal pupil morphology 0.3956495261774309 0.47722661037471 0.6332007641666093 1.0 0.909641170872327 11 O96028,Q96ST3,Q13363,Q9NR77,Q12948 5 +Sparse body hair 0.4105213573431776 0.4760957437084211 0.6340061691584691 1.0 0.909641170872327 9 P04080,P48449,P14923,Q9BZH6,Q06787 5 +Rectal prolapse 0.4168221705017534 0.4759446501166887 0.6341138111137066 1.0 0.909641170872327 8 Q15056,P35250 2 +Elevated circulating alanine aminotransferase concentration 0.410456111515514 0.4757983858741065 0.6342180199224252 1.0 0.909641170872327 9 P10253,Q15904 2 +Short ribs 0.4166223688790073 0.4750630194435914 0.6347420559166865 1.0 0.909641170872327 8 Q14739 1 +Aplasia hypoplasia of the patella 0.4902991103312569 0.4745847741565101 0.6350829608079913 1.0 0.909641170872327 5 Q9Y619,Q9Y5S9 2 +Hypoparathyroidism 0.4027275770388863 0.4701250692391524 0.6382656643923097 1.0 0.9113062329075085 10 P00403,P40939,Q8WYQ5 3 +Abnormal circulating protein concentration 0.2909174936861242 0.469192425898472 0.6389320988560252 1.0 0.9113062329075085 121 P35250,P09651,P40939,Q15120,Q5JRX3,P31483,Q13501,Q6ZXV5,O43772,Q8NFF5,Q8NFH4,P23786,Q9NWM8,P41440,O75340,Q16836,O95831,Q00059,O43505,Q9Y487,Q15056,P22626,Q13642,Q9Y4P3,Q5XKP0,O14979,O75648,Q9H0R6,P10253 29 +Aplasia hypoplasia involving the femoral head and neck 0.4725677736259539 0.468968502552514 0.6390921501246019 1.0 0.9113062329075085 6 O95831 1 +Hemifacial spasm 0.6012518860844316 0.4656511014855358 0.6414652586946352 1.0 0.912283228040634 3 Q969G3 1 +Myoclonic spasms 0.6012518860844316 0.4656511014855358 0.6414652586946352 1.0 0.912283228040634 3 Q969G3 1 +Profound sensorineural hearing impairment 0.5093028256819108 0.4646531153016771 0.6421798886081751 1.0 0.9127126116047424 4 Q9NR77 1 +Abnormality of humoral immunity 0.3103353222496486 0.4642049651761755 0.6425009042183996 1.0 0.9128755217982591 47 Q14108,P28070,P04062,P18074,Q9Y5S9,P09601,Q96J02,P17812,Q15904 9 +Tetraplegia 0.4012626365562125 0.4632561811186875 0.6431807505712601 1.0 0.9135479960747218 10 Q13423,O95831,O43681 3 +Death in adulthood 0.383490330854116 0.4619752192355632 0.644099091309664 1.0 0.9140996217649648 12 Q15056,P05067,P35250 3 +Abnormal circulating amino acid concentration 0.3187439575353687 0.4618496684936808 0.6441891297855291 1.0 0.9140996217649648 41 Q9Y619,P41440,O15382,P05067,P35270,P20674,Q5XKP0,Q99797 8 +Abnormality of the fontanelles or cranial sutures 0.2945525522785781 0.4613790038321435 0.6445267125173528 1.0 0.9142853269609532 73 Q9Y619,P21964,Q8NCH0,P16435,P07237,Q6NUK1,Q5SRE5,Q00577,P98175,P48651,Q16134,P13804,O75718,O75844,P18074,Q92785,P20674,Q9UM00,O95831,O75431,P61978,Q14738,Q9Y487,Q96AY3 24 +Abnormal pyramidal sign 0.279957022636539 0.4597535896852936 0.6456930990623149 1.0 0.915646225441686 104 Q9Y619,Q9NR77,P40939,P37198,Q13501,O75306,O15382,O60701,Q99720,Q8N0X7,P41440,P18074,O95831,Q15067,Q6DKK2,Q9NZ08,P17900,O95140,P35637,Q9Y263,O43681 21 +Hyperlipidemia 0.334312535914355 0.4562482024071064 0.6482115067700889 1.0 0.9177463170435668 27 P28070,P06280,O75844,P23786,P31751,O75431 6 +Aplastic hypoplastic toenail 0.3294294889068662 0.4549144031910816 0.649170820466576 1.0 0.918064764424366 31 Q15056,P23786,Q14738,P35250,Q9Y4P3,Q14739 6 +Dystrophic fingernails 0.4399313939498822 0.4539336203696618 0.6498766043485691 1.0 0.918595656930496 7 O75844 1 +Heterotaxy 0.5061298767848694 0.4536782243006774 0.6500604422298988 1.0 0.918595656930496 4 O96028 1 +Vocal cord paralysis 0.3602098414869844 0.4528219790686351 0.6506769356298596 1.0 0.9187698411397732 16 Q02978,Q9NR77,O95140 3 +Chronic hepatic failure 0.5964775141186441 0.4507744390227056 0.6521521256260676 1.0 0.9187698411397732 3 P40939 1 +Epistaxis 0.3681641159987942 0.4506894098205479 0.6522134160592703 1.0 0.9187698411397732 14 Q86YV9,O15460,P04062 3 +Abnormality of fluid regulation 0.2935346320228888 0.4506505952183464 0.6522413950372834 1.0 0.9187698411397732 128 Q14108,Q9NZ08,P28070,Q99519,Q15056,P06280,P04062,P07437,P35250,P23786,P10619,Q15555,Q9Y4P3,P16278,P40939,Q13510,Q9UBM7,Q14739 18 +Periventricular heterotopia 0.4032336167982027 0.4431307849488208 0.6576711392408834 1.0 0.9222929350993854 9 Q6NUK1,Q9UBM7 2 +Abnormality of the nasal bone 0.5936488712476754 0.4420472526338023 0.6584550128021369 1.0 0.9222929350993854 3 Q6NUK1 1 +Motor axonal neuropathy 0.3795867492724603 0.4419693020623345 0.658511420064483 1.0 0.9222929350993854 12 O95831,P22626 2 +Increased csf lactate 0.31647693286356 0.4416981565623384 0.6587076438360895 1.0 0.9222929350993854 41 Q8IUX1,O75306,Q8N183,Q9HC21,O43464,P00403,O95831,O43676,Q9P032,Q9Y375 10 +Proximal amyotrophy 0.3795299859914236 0.4416795773188133 0.6587210902055072 1.0 0.9222929350993854 12 P35637 1 +Head titubation 0.4365740823751237 0.4404249633766655 0.6596293479794892 1.0 0.9226883637296904 7 P35637 1 +Congenital hip dislocation 0.3446375595699862 0.438335988314395 0.6611427414248772 1.0 0.9235956574352774 21 Q15738,Q9UHX1,Q14738,Q9Y487,Q13642 5 +Coarctation of aorta 0.3283388171861411 0.4359242380377942 0.662891698797208 1.0 0.9235956574352774 30 Q9UHX1 1 +Polyhydramnios 0.3191685782351628 0.4357704815899473 0.6630032626423339 1.0 0.9235956574352774 37 Q9UBM7,O75844,Q14739 3 +Gray matter heterotopia 0.3416670055606589 0.4355619313871301 0.6631545961282006 1.0 0.9235956574352774 22 O43505,Q6ZXV5,Q9BVA1,Q86XL3,Q6NUK1,Q9UBM7 6 +Microcornea 0.3440659123595782 0.4345699855344879 0.6638745851337164 1.0 0.9235956574352774 21 Q9NWM8,Q15555,P07437,P18074 4 +Hypoplastic nipples 0.4064254179203914 0.4305710036770402 0.6667803285953449 1.0 0.924862649739892 8 P07437 1 +Hypersplenism 0.4334927306895714 0.428119224744094 0.6685643208376546 1.0 0.9251926269076768 7 Q14108 1 +Broad thumb 0.3430270535952379 0.4277360716832705 0.6688432846733532 1.0 0.9251926269076768 21 O75648,Q9UHX1,O96019 3 +Abnormality of metacarpal epiphyses 0.4772403313304886 0.4275894631830607 0.668950038627798 1.0 0.9251926269076768 5 O96028,Q13363 2 +Equinovarus deformity 0.4765917483783627 0.4252950269714621 0.6706216183614553 1.0 0.9257676086182012 5 Q9NR77 1 +Thoracic kyphoscoliosis 0.4606847072778379 0.4247055432551934 0.671051342348056 1.0 0.926071790079704 6 O75844 1 +Abnormality of circulating glucocorticoid level 0.3925681748819937 0.4229273061712173 0.6723482994495491 1.0 0.9267679500404103 10 P16435,Q13423,Q969G3,P10644,Q9H0R6 5 +Sparse or absent eyelashes 0.3420513821262092 0.4213298703193527 0.6735142212726597 1.0 0.9274450188944502 21 P48449 1 +Abnormal ureter physiology 0.3173721812262439 0.4206171556908777 0.6740346642770167 1.0 0.9274806366506588 37 Q9UHX1,Q15056,Q86XL3,P35250,Q9UBM7 5 +Gastrointestinal obstruction 0.3838024426249372 0.4194794348987166 0.674865781255048 1.0 0.928037245000122 11 Q01844,P18074 2 +Distal muscle weakness 0.3019413329472188 0.418699913860243 0.6754354586499418 1.0 0.928037245000122 49 P41440,O75340,P04792,O95140,Q99720,P22626,P35637,P09651,Q9NR77,Q96BR5,P40939,O95831,P31483,Q13501 14 +Bifid scrotum 0.4746693322762037 0.4185172969470626 0.6755689427876386 1.0 0.928037245000122 5 Q9UBM7 1 +Redundant neck skin 0.4955636942753046 0.4177774335975069 0.6761098514997139 1.0 0.928037245000122 4 Q9Y487,P82650 2 +Acanthosis nigricans 0.3913374200431632 0.4172821529166705 0.6764720410551748 1.0 0.928037245000122 10 P31751,P28070 2 +Psoriasiform dermatitis 0.5851581084023343 0.4162517218961539 0.6772258159164544 1.0 0.9282211911368076 3 P10321 1 +Aplasia hypoplasia affecting the anterior segment of the eye 0.3431509989287086 0.413438308745639 0.6792855122715842 1.0 0.9298916189344528 20 Q15056,O96028,Q9Y4P3,P35250 4 +High pitched voice 0.3903265314972112 0.4126578305547516 0.6798573247309969 1.0 0.9300986536607484 10 O75844,O75431,P07237 3 +Movement abnormality of the tongue 0.583761615761156 0.4120682117894232 0.6802894273795048 1.0 0.9301931191272376 3 P10253 1 +Puberty and gonadal disorders 0.292925882155151 0.4116935071124877 0.6805640846163676 1.0 0.9301931191272376 132 O95721,Q16740,P06280,P35250,P48735,O75874,Q14108,P48449,O75844,P18074,P00403,Q9BW83,Q9UBM7,Q15056,P04062,O96028,P51809,Q15555,Q9Y4P3 19 +Abnormality of prenatal development or birth 0.3144508245051676 0.4114158860969575 0.6807676071930517 1.0 0.9301931191272376 179 Q9Y619,Q9UHX1,P35250,P16278,P40939,Q9Y375,Q13501,Q14739,O75306,O43772,P23786,Q13510,Q99519,P61916,O75718,O75844,P18074,P10619,O43676,Q9UBM7,Q70HW3,Q15056,P04062,O96028,Q9Y4P3,Q9Y487 26 +Cough 0.3348228214624211 0.4074414995718753 0.6836837522997548 1.0 0.9333127272906836 23 Q9NR77,P04062,O15460 3 +Lipodystrophy 0.3222840988102696 0.3995263680380435 0.6895053988317668 1.0 0.9385467668708816 31 P28070,O75844,Q6NUK1,P31751,Q9Y487,O75431 6 +Abnormal myeloid cell morphology 0.4883330672701527 0.3938146189821737 0.6937179104468856 1.0 0.9403353717151623 4 P41440 1 +Functional abnormality of the gastrointestinal tract 0.3244271183889478 0.390959752446911 0.6958269857418302 1.0 0.941149450764665 215 Q9Y619,Q01105,Q9UHX1,P06280,P08183,P35250,Q01844,Q6NUK1,Q9NR77,P48735,P37198,P42892,Q14739,Q13501,O75306,Q6ZXV5,P07737,P05067,O75874,Q13510,Q99720,Q99519,Q14108,Q9BUF5,P61916,P18074,P00403,Q15067,Q9UBM7,Q9NZ08,O15460,Q15056,P04062,O96028,P35637,Q03164,Q9Y4P3 37 +Abnormality of the sense of smell 0.3496495680641799 0.3908170233159705 0.6959324909613205 1.0 0.941149450764665 16 O95140,P04062,O43464,Q969G3,Q9BW83 5 +Regional abnormality of skin 0.2774850646956486 0.3905473090004988 0.6961318795595082 1.0 0.941149450764665 108 Q9UHX1,Q15056,Q06136,O75648,O95721,P61978,O96028,P35250,P18074,Q6NUK1,O96019,Q9Y4P3,Q96J02,Q9Y487,Q9UBM7,O75431,Q14739 17 +Abnormal spermatogenesis 0.369282359974575 0.3899730207800289 0.6965564969620268 1.0 0.941149450764665 12 P16435,P04062,P51809,Q9BZH6,Q13423 5 +Abnormal large intestine physiology 0.3691838560682642 0.3894820634537286 0.6969195765542309 1.0 0.941149450764665 12 P06280,P21964,O43681 3 +Aphasia 0.317968023763507 0.3889171704009329 0.6973374200253171 1.0 0.941149450764665 33 Q15738,P21964,P05067,P22626,O96019,P00403,O75648,P31483,Q13501 9 +Cirrhosis 0.319417933237412 0.3882294270033577 0.6978462580921487 1.0 0.941149450764665 32 Q14108,P04062,Q14739 3 +Opisthotonus 0.3391295924414447 0.3877412658900723 0.6982075144453299 1.0 0.941149450764665 20 P35637,Q99720,P04062,P11117 4 +Hypogonadism 0.2878482354518321 0.3875545637615791 0.6983456986545247 1.0 0.941149450764665 75 P48449,Q15056,O95721,Q16740,O75844,P51809,P35250,P18074,P00403,Q15555,Q9BW83 11 +Muscle fiber atrophy 0.3430092373080937 0.3875333426639621 0.6983614056996679 1.0 0.941149450764665 18 P61978,P23786,P22626,P35637,Q99720 5 +Soft skin 0.4230131330203878 0.3869702632756436 0.698778222702904 1.0 0.941424331104156 7 Q13126 1 +Abnormal circulating bilirubin concentration 0.3287009109059229 0.3845780369590224 0.7005500688828743 1.0 0.9423762027581974 24 P41440,P23786,Q14739 3 +Long eyelashes 0.3202677352860156 0.384024036118758 0.7009606326252094 1.0 0.9424987758226432 31 Q9Y619,Q9UHX1,Q6NUK1,Q03164,P20674,Q969G3 6 +Diabetes insipidus 0.3678476269515837 0.3828341458689402 0.7018427419664055 1.0 0.9424987758226432 12 O15460 1 +Long penis 0.5350734094616708 0.3824937198573541 0.7020951862610285 1.0 0.9424987758226432 2 O00170 1 +Impaired distal proprioception 0.5350734094616704 0.382493719857352 0.7020951862610301 1.0 0.9424987758226432 2 Q6PI48 1 +Abnormality of visual evoked potentials 0.3480137541325653 0.3813376018291497 0.7029527555320683 1.0 0.9427475039991552 16 O75503,O43681 2 +Gastroparesis 0.4486907199151929 0.3813311322014862 0.7029575555480927 1.0 0.9427475039991552 6 O43464,P61978 2 +Progressive spasticity 0.3581052477146955 0.3784274689954253 0.7051130654728879 1.0 0.9439210316545348 13 Q9Y263,P17900,O43681 3 +Enlarged ovaries 0.5711488384195575 0.3750750470999192 0.7076046541471945 1.0 0.9460004524472024 3 P10644 1 +Radioulnar synostosis 0.3500336271429761 0.3705713209533434 0.7109568460899054 1.0 0.9467312663845274 15 Q15056,O96028,P35250 3 +Abnormal pattern of respiration 0.297472156195773 0.3674799112994667 0.7132610737211835 1.0 0.948566336816444 147 Q9Y619,Q9UHX1,P06280,Q92804,Q13501,O75306,O43772,P07737,Q16134,P23786,Q15165,Q13510,P13804,O75844,P16219,O95831,Q96GM8,P22695,P04062,P35637,P10253 21 +Decreased circulating cortisol level 0.4177487363825518 0.3667351368547872 0.7138165945333146 1.0 0.948566336816444 7 Q13423,Q9H0R6,Q969G3 3 +Abnormality of the nasal dorsum 0.3079309796188019 0.3663818982959168 0.71408012518919 1.0 0.948566336816444 41 O95721,P61978,O75844,O96028,Q6NUK1,P18074,P16278,Q96J02,O75431 9 +Spastic tetraplegia 0.3164886820138115 0.3654529432479251 0.7147733270116707 1.0 0.948812252512791 32 P16278,O43681 2 +Finger syndactyly 0.3309548728659895 0.3643313982766433 0.715610556243514 1.0 0.94887026537273 22 Q9Y619,Q9Y2U8,P98175,P48651,Q9Y5S9,Q9BW83,Q9UBM7,Q96EK5 8 +Caesarian section 0.4791836734693824 0.3642448830046235 0.7156751538058845 1.0 0.94887026537273 4 Q96EY7,O60313,O14802 3 +Central hypoventilation 0.458178858228672 0.3618686405157468 0.7174501952844594 1.0 0.9509386316281584 5 O75306 1 +Abnormal morphology of the abdominal musculature 0.4577378215151147 0.3603920834666985 0.7185539459309607 1.0 0.9514800941206176 5 Q6NUK1,P09651 2 +Astrocytosis 0.4426913885402863 0.3601710885431644 0.7187191938632111 1.0 0.9514800941206176 6 Q13501 1 +Abnormal ureter morphology 0.3511749912436772 0.3580151949855082 0.7203319422852059 1.0 0.9530446248063016 14 O75844 1 +Abnormal thorax morphology 0.3062125876943469 0.3564592134855218 0.7214966916024388 1.0 0.9537791066604632 168 Q9Y619,Q9UHX1,P35250,P07237,P16278,Q13501,Q14739,Q6ZXV5,P07437,Q13510,Q99519,Q15738,O75340,O75718,O75844,O96019,P18074,Q9Y5S9,O95831,Q9UM00,Q96J02,Q9UBM7,O75431,Q15056,O75648,P61978,P51648,P04062,O96028,Q9Y263,Q03164,Q15555,Q9Y4P3,P54802,Q9Y487,Q13642 36 +Impaired vibratory sensation 0.3269650780757001 0.3544020074624077 0.7230376303338999 1.0 0.9551957703007286 23 Q9Y619,Q9NR77,Q8N0X7,Q15120 4 +Cutis laxa 0.3238354551268195 0.3511634928113116 0.7254656967183117 1.0 0.9570103151096166 24 Q15056,P35250,Q9Y4P3,Q9Y487,Q15904 5 +Abnormality of the spinal cord 0.2867758714978392 0.3509384542880499 0.7256345215797191 1.0 0.9570103151096166 53 Q9UHX1,Q15056,P05067,O96028,P35250,P16278 6 +Frontal balding 0.523654159869503 0.3479043486391303 0.7279120193125643 1.0 0.9587715489635116 2 O60828 1 +Abnormal male reproductive system physiology 0.3133191121157306 0.3409650057868746 0.7331299261666933 1.0 0.962777215984348 32 Q15056,P16435,P04062,P51809,O43464,Q9BZH6,P35250,Q13423,Q9Y4P3,Q969G3,Q06787 11 +Telecanthus 0.310212537653023 0.3403093267829102 0.7336235941229943 1.0 0.9631395538159704 34 P13804,Q16134,Q86XL3,O75844,Q03164 5 +Accessory spleen 0.4365990129551341 0.3390735993529074 0.7345542862517713 1.0 0.964075254626583 6 O96028,Q15904 2 +Pointed chin 0.3215651199966817 0.3356987031890823 0.7370980838372065 1.0 0.9657467238114056 24 Q15056,P35250,Q9Y4P3,P11233,Q96EK5 5 +Episodic pain 0.372922098305904 0.3349356316873649 0.7376736427337007 1.0 0.9661624287270236 10 Q02978,P23786 2 +Functional motor deficit 0.2739632419427831 0.3332296466926276 0.7389609409140845 1.0 0.9664079359818118 109 P04792,Q9NR77,P40939,Q15120,P10644,P31483,P37198,Q13501,Q8NFF5,P23786,Q969G3,Q9H2D1,Q9NWM8,Q13510,Q99720,Q8N0X7,Q8IUX1,O75340,Q8NC96,Q15041,Q9HC21,P00403,Q15067,P12235,O95140,P61978,P04062,P35637,Q07021,Q13642,O43681 31 +Cerebellar atrophy 0.2729970713104111 0.333019880384636 0.7391192764907486 1.0 0.9664079359818118 99 Q13155,Q10713,Q5JRX3,P57081,Q13501,Q4G0N4,Q16795,Q8IV08,P07437,Q13217,Q96BR5,O75503,O14773,Q9Y3E5,P18887,Q8N0X7,Q14108,P41440,Q9BVA1,Q96S52,Q13363,P18074,P12235,Q6DKK2,P13073,O15160,Q9NQT5,Q9Y263,Q06787,Q5XKP0,O75648 31 +Poor suck 0.3260757658702735 0.3324388491218137 0.7395579076095691 1.0 0.9666266623395756 22 O75306,P22695,O43464,P40939,O75648,Q9UBM7 6 +Decreased activity of mitochondrial complex iv 0.3461409908605972 0.3312982226522082 0.7404192336952584 1.0 0.9669827849713188 14 P13073,P52815,P20674,Q9Y2R0,Q9H0R6,Q70HW3 6 +Corneal neovascularization 0.4686180146524727 0.3312094905234046 0.7404862520230289 1.0 0.9669827849713188 4 P18074 1 +Aplasia hypoplasia of the radius 0.3488282323839125 0.3306013695327141 0.7409456115983346 1.0 0.9671030535633652 13 Q9UBM7,Q9Y5S9,Q96AY3,P10644 4 +Irritability 0.2838088887604364 0.3302192405589698 0.7412343096495158 1.0 0.9671030535633652 66 Q9NZ08,O43772,P50897,O95831,Q13510,Q13501 6 +Abnormality of pelvic girdle bone morphology 0.2749436083139433 0.3297879631494881 0.7415601830540752 1.0 0.9672429046441092 111 Q9Y619,Q9UHX1,P35250,P16278,Q14739,Q15738,O75718,O75844,O96019,Q9Y5S9,O95831,Q9UBM7,O75431,Q9Y487,Q15056,P61978,O96028,Q14738,Q9Y4P3,O75648 20 +Joint hemorrhage 0.5171288743882663 0.328862074409139 0.74225994150692 1.0 0.9678702008505624 2 P49257 1 +Myotonia 0.4074376787903608 0.3280183017897736 0.7428978247055107 1.0 0.9684164688100424 7 P50402,Q13642,P02545,Q9BTV4,Q00577,Q8WXH0 6 +Aplasia hypoplasia involving bones of the lower limbs 0.283522809110858 0.3270326181918005 0.7436432146942997 1.0 0.9686717965448768 66 Q9Y619,O75431,Q9UHX1,Q13510,O96028,Q13363,O96019,Q03164,Q9Y5S9,O95831,Q06787,P10644,P55011,O75648,O00116,Q9UBM7,Q8N0X7 17 +Osteopenia 0.2834477903032734 0.3270225080111473 0.7436508614237645 1.0 0.9686717965448768 63 Q14108,Q15056,Q13126,O75718,O75844,P04062,P35250,P18074,Q9Y4P3,Q9NWM8,Q9Y487 11 +Abnormal phalangeal joint morphology of the hand 0.3246340131121121 0.3230884270602226 0.7466282745323376 1.0 0.9690980136611884 22 Q9Y619,O75844 2 +Abnormality of the hypothalamus pituitary axis 0.2830005803938936 0.322839385164347 0.7468168836931177 1.0 0.9690980136611884 62 P48735,Q9UHX1,O75874 3 +Abnormality of the glabella 0.4460516674717437 0.3220519973261507 0.7474133029942971 1.0 0.969288233913914 5 O96028 1 +Abnormality of the liver 0.3238501584444726 0.3219227353114952 0.7475112290030208 1.0 0.969288233913914 233 Q9Y619,P28070,Q8N183,P21964,P35250,Q01844,P31751,P09651,P16278,P09601,P40939,O75880,P10644,Q15904,Q9Y375,Q14739,O75306,O43772,Q16134,P23786,Q969G3,Q13510,Q99519,Q14108,P61916,P13804,O75340,P00374,P10619,Q16836,P16219,P20674,O43676,Q15067,Q9Y5S9,Q96J02,Q9BW83,Q9UBM7,Q00059,O75431,O15118,Q15056,O95140,P04062,O96028,P22626,P54802,Q9Y4P3,Q9P032,Q5XKP0,O75648,P10253,O43681 53 +Decreased circulating iga level 0.3799747334719037 0.3204613101199819 0.748618655140814 1.0 0.9698712102190452 8 Q15904 1 +Neonatal onset 0.3280109250905878 0.3179060562041532 0.7505561985561471 1.0 0.9720966518927784 20 Q9P032,P16219,P40939,Q15904 4 +Abnormality of the nail 0.2754016852099912 0.3172317103975398 0.7510677901702345 1.0 0.972474483584001 93 Q9Y619,P10321,Q06136,P35250,Q6NUK1,P10644,P42892,Q14739,P48651,P23786,Q969G3,Q15738,O75844,Q13363,P18074,O75431,Q15056,O96028,Q14738,Q9Y4P3,Q9Y487,Q13642 22 +Aplasia cutis congenita of scalp 0.4436605049613135 0.3143997411442467 0.7532174527261377 1.0 0.9736157549601964 5 O96028 1 +Increased muscle lipid content 0.4036846570615957 0.3142451314375738 0.7533348675619729 1.0 0.9736157549601964 7 P23786 1 +Ventricular fibrillation 0.5491636066911519 0.3142323145811398 0.7533446012890537 1.0 0.9736157549601964 3 Q9NX14,P15924 2 +Abnormal hand morphology 0.280111660355725 0.3136738817901688 0.7537687396116304 1.0 0.9736157549601964 81 Q9UHX1,O75844,O95831,Q13510,Q9UBM7 5 +Decreased cervical spine flexion due to contractures of posterior cervical muscles 0.4289215686274528 0.3130778002666763 0.7542215547083879 1.0 0.9736157549601964 6 P50402,Q15149,Q13642,Q9BTV4,Q8WXH0 5 +Progressive microcephaly 0.3096678659343726 0.3129745419135983 0.7543000038145284 1.0 0.9736157549601964 32 Q96GM8,O95721,Q9HC21,Q9Y263,P50897,Q9Y487,Q9Y3E5 7 +Deviation of the hallux 0.314271065139283 0.3111786974266138 0.7556647766520439 1.0 0.9737894013943156 27 Q15056,P04062,O96019,P35250,Q9Y4P3,Q96J02,O75648 7 +Deep palmar crease 0.3605505039115921 0.3109348853041203 0.7558501234067259 1.0 0.9737894013943156 11 Q96AX1,P98175,P61978,Q6NUK1,Q9Y487,O75431 6 +Abnormal aortic morphology 0.2773044154408839 0.3105744400913066 0.756124160748759 1.0 0.9737894013943156 88 O15460,Q9UHX1,Q15056,Q6ZXV5,P61978,P04062,O75844,P35250,Q6NUK1,O96019,Q9Y4P3,Q9Y5S9,Q9NWM8,O75648,Q9UBM7,Q8WYQ5 16 +Abnormal enzyme coenzyme activity 0.2938691721861424 0.3102680797402889 0.7563571028642486 1.0 0.9737894013943156 148 Q9Y619,P28070,P16278,P40939,Q5JRX3,Q15904,Q13501,Q14739,O43772,O15382,P23786,Q13510,P41440,P61916,O75340,P10619,Q16836,P20674,Q15067,Q00059,O75431,O43505,P22695,P04062,P22626,Q5XKP0,O75648,P10253 28 +Cerebellar cyst 0.3115449208472997 0.3094308581558936 0.7569937999730729 1.0 0.9737894013943156 30 Q9Y487,Q9UBM7,P07437 3 +Abnormal ovarian morphology 0.3225054241679546 0.3093483136727603 0.7570565830164244 1.0 0.9737894013943156 22 Q15056,P16435,P51809,P35250,Q9BZH6,P31751,Q9Y4P3,P82650,P10644,Q9BW83 10 +Abnormality of the clitoris 0.335351473852715 0.3092674360103241 0.757118099836775 1.0 0.9737894013943156 16 Q9Y619,Q9UBM7,Q96GM8 3 +Glomerular deposits 0.5101957585644492 0.3092292714158819 0.757147128961124 1.0 0.9737894013943156 2 P57740 1 +Congenital malformation of the great arteries 0.2790104347495827 0.3079688151721408 0.7581060616996336 1.0 0.9746167064305064 83 O15460,Q9UHX1,Q15056,Q6ZXV5,O75844,Q15392,P35250,Q6NUK1,Q9Y4P3,Q9Y5S9,Q969G3,Q9NWM8,Q9UBM7,Q8WYQ5,P42892 15 +Amniotic constriction ring 0.5077487765089779 0.302451048610465 0.7623082445464562 1.0 0.9775516223008376 2 Q9H4L7 1 +Muscle fiber inclusion bodies 0.3754115842866993 0.3023603974697539 0.7623773409413555 1.0 0.9775516223008376 8 O75340,O43676 2 +Joint laxity 0.2808110656430801 0.3012701002969054 0.7632085388750176 1.0 0.9776053771920656 60 Q9Y619,Q9UHX1,Q8NCH0,P35250,P16278,Q32P28,Q96C86,Q9BZH6,Q969G3,O75340,Q96S52,Q92785,P55795,Q96A33,Q15233,Q15056,P61978,P36543,Q9Y4P3,Q06787,Q9Y487,Q96AY3 22 +Renal hypoplasia aplasia 0.2807975957703739 0.2998834980548356 0.7642660220195772 1.0 0.97839323166211 61 O75306,Q9UHX1,Q15056,Q9UBM7,Q86XL3,P35250,Q15392 7 +Abnormal left ventricle morphology 0.3161885741877882 0.2994265915594905 0.764614575205044 1.0 0.97855621126502 24 P06280,P10253,Q6NUK1,P00403,P78536,P40939,O75880,Q07021,P12235,O75431 10 +Abnormal glucose homeostasis 0.2939601140459509 0.2980144934571241 0.7656921017783374 1.0 0.979651769211914 150 Q06136,P35250,P31751,Q13423,P40939,O75880,P10644,Q9Y375,O75306,O43772,Q16134,P23786,Q9BZH6,Q9Y3E5,P13804,O75844,P00403,Q16836,P16219,O43676,Q96J02,Q00059,O75431,Q15056,O95140,P17096,P22695,Q14738,Q15555,Q9Y4P3,Q5XKP0,Q9H0R6,Q9P032,Q8N183 34 +Impaired t cell function 0.3737749004827766 0.2959392977811009 0.7672764392110603 1.0 0.9808276562515952 8 Q8WYQ5,P17812 2 +Supernumerary spleens 0.3969780528916681 0.2900821706534859 0.7717533754068275 1.0 0.9834177512774448 7 O96028,Q15904 2 +Abnormality of the pharynx 0.299802916020749 0.2890985820284293 0.7725059386694828 1.0 0.9834177512774448 40 Q86YV9,O15460,P21964,P54802,Q969G3,P16278,Q13510 7 +Recurrent paroxysmal headache 0.371033445630488 0.285270501615036 0.7754369106049008 1.0 0.9842457667564106 8 Q02978,P00403 2 +Brain imaging abnormality 0.318683802579618 0.2848822898930423 0.7757343246418846 1.0 0.9842457667564106 22 P00403,O75306,Q13501 3 +Macroorchidism 0.4529436699826596 0.2845650146878623 0.7759774177222589 1.0 0.9842457667564106 4 P38159 1 +Protrusio acetabuli 0.5372979094994332 0.2834698986374077 0.7768166531416729 1.0 0.9842457667564106 3 O75718 1 +Gait imbalance 0.3240877891049384 0.2833462494806358 0.7769114272973845 1.0 0.9842457667564106 19 Q9NR77,Q15056,Q9Y4P3,P35250 4 +Progressive external ophthalmoplegia 0.370286666340181 0.2823833759194125 0.7776495606235949 1.0 0.9842457667564106 8 P00403,P16219,P12235 3 +Multiple joint contractures 0.3305030431712816 0.2823492904540092 0.7776756940273442 1.0 0.9842457667564106 16 P41440,O75844 2 +Facial edema 0.310553038175997 0.2815277425539311 0.7783056526896024 1.0 0.9842457667564106 26 P28070,Q15056,P35250,Q9Y4P3,Q99519 5 +Abnormal cerebral artery morphology 0.3467283249632423 0.2810546345245544 0.7786684956144589 1.0 0.9842457667564106 12 P10253 1 +Cerebellar malformation 0.2960301172483793 0.2797568851719006 0.7796640319906962 1.0 0.984428779187796 43 Q15056,P23786,P07437,P35250,Q9Y4P3,Q969G3,Q9Y487,Q9UBM7 8 +Abnormal protein glycosylation 0.3463632926162697 0.2793552942230357 0.7799721758864733 1.0 0.9844900105852928 12 Q9Y487,Q15904 2 +Abnormality of the pubic bone 0.4508893164444124 0.2786725957368408 0.7804960951240827 1.0 0.9846361177221384 4 O96028 1 +Abnormality of the pulmonary vasculature 0.306723307531745 0.274019106267561 0.7840699387443593 1.0 0.985152849949086 30 Q15056,O75718,P35250,Q9Y4P3,O75648,Q15392,Q8WYQ5 7 +Increased serum iron 0.5333376266159441 0.2735447412665798 0.7844345046832588 1.0 0.985152849949086 3 Q658P3 1 +Hyperreflexia 0.3069527633832201 0.2725354547911117 0.7852103336255964 1.0 0.985152849949086 185 Q9Y619,Q86XL3,Q13409,P35250,Q9NR77,Q5JRX3,O14949,P37198,Q13501,Q14739,O75306,O15382,O43464,O60701,O75503,Q99720,Q8N0X7,Q99519,O75340,Q9BVA1,P18074,P20674,O95831,Q15067,Q6DKK2,Q9NZ08,P17900,Q15056,Q96GM8,P04062,P35270,P35637,Q15555,Q9Y4P3,Q5XKP0,O43681 36 +Blue irides 0.3677024882623901 0.2724568668423403 0.785270752402496 1.0 0.985152849949086 8 Q15056,Q9Y4P3,P35250 3 +Reduced brain n acetyl aspartate level by mrs 0.4963295269168155 0.2718906763669898 0.7857060804610676 1.0 0.985152849949086 2 Q9NZJ7 1 +Abnormal brain choline level by mrs 0.4963295269168155 0.2718906763669898 0.7857060804610676 1.0 0.985152849949086 2 Q9NZJ7 1 +Abnormal brain n acetyl aspartate level by mrs 0.4963295269168155 0.2718906763669898 0.7857060804610676 1.0 0.985152849949086 2 Q9NZJ7 1 +Abnormality of hair pigmentation 0.3165324611319883 0.2712295704135913 0.7862144711881676 1.0 0.985152849949086 22 Q86YV9,Q9Y2Q5,Q13126,Q9UM00,P10644,Q9UBM7 6 +Abnormality of the pulmonary artery 0.3092767434234556 0.2704372914808937 0.7868238540645538 1.0 0.985152849949086 25 Q15056,O75718,P35250,Q9Y4P3,O75648,Q8WYQ5 6 +Middle age onset 0.3671408874025457 0.2703129337629962 0.7869195159100433 1.0 0.985152849949086 8 P31930 1 +Ventricular escape rhythm 0.4287464271131057 0.2682460303229599 0.78850994576244 1.0 0.9863064168855408 5 Q13642,Q9BTV4,Q8WXH0,P50402 4 +Abnormal muscle fiber protein expression 0.4287464271131057 0.2682460303229599 0.78850994576244 1.0 0.9863064168855408 5 Q13642,Q9BTV4,Q8WXH0,P50402 4 +Cogwheel rigidity 0.5308018647979137 0.2672817566549624 0.7892522320509681 1.0 0.9869466990712183 3 P37198 1 +Abnormal 5th finger morphology 0.2776087587824423 0.266537335579376 0.789825409360492 1.0 0.9871143785254184 74 Q9Y619,Q9UHX1,Q15056,Q8NFH4,P35250,Q9Y263,Q03164,Q9Y5S9,Q9Y4P3,Q969G3,Q9UM00,Q9BW83,Q9UBM7,Q14739 14 +Hypermetropia 0.2961553507164702 0.2647104711743243 0.7912325103421503 1.0 0.9877975342857322 41 Q9UHX1,Q15056,P35250,Q9Y4P3,Q15904,P68371 6 +Extra axial cerebrospinal fluid accumulation 0.4934747145187655 0.26453202435836 0.7913699915243182 1.0 0.9877975342857322 2 P20700 1 +Petechiae 0.3559962016410611 0.2632812608610286 0.7923338019972175 1.0 0.9880159025186616 10 P04062,Q99519 2 +Increased nuchal translucency 0.3300625162787506 0.2625425348511001 0.7929031969937228 1.0 0.98844724923992 15 Q9UBM7,Q15056,Q9Y4P3,P35250 4 +Pectus carinatum 0.310525964912072 0.2618064856121005 0.7934706386335346 1.0 0.9887062875116244 24 Q9Y619,Q96S52,P08236,Q9Y263,P16278,P55011,Q96AY3,Q99519 8 +Obsessive compulsive behavior 0.3015791874595412 0.2614495474201019 0.7937458519981138 1.0 0.9887062875116244 33 Q15056,P35250,Q9Y4P3,O75503,Q6DKK2,Q13501 6 +Aplasia hypoplasia of the extremities 0.2847760713872749 0.2614031834886499 0.7937816022956767 1.0 0.9887062875116244 137 Q9Y619,Q9UHX1,Q6NUK1,P48735,Q15392,Q14739,O75874,Q969G3,Q13510,Q8N0X7,Q15738,O75718,O75844,O96019,Q9Y5S9,O95831,Q9UBM7,Q96EK5,O96028,Q03164,Q15555,O75648 22 +Biventricular hypertrophy 0.4918433931484612 0.2603785447314269 0.7945717911575689 1.0 0.9891652476559925 2 P36543 1 +Adult onset 0.276393884068056 0.259447386752935 0.7952900716771609 1.0 0.9895678667508366 57 P41440,O15118,P04792,P17096,P31930,Q8IV08,P04062,P31751,O14979,Q969G3,P12235,Q06787,Q13642,P31483,Q9UJV9 15 +Abnormal chromosome morphology 0.4914355628058832 0.2593460532475983 0.7953682492198111 1.0 0.9895678667508366 2 O95453 1 +Polymicrogyria 0.2763590666018945 0.2552099470419471 0.7985609487679981 1.0 0.9906247697804196 59 Q15738,Q01105,Q6ZXV5,Q9BVA1,O95721,P07437,P23786,Q9Y487,Q15392,Q96EK5 10 +Depressed nasal ridge 0.3219829054273352 0.2551299764597954 0.7986227122100185 1.0 0.9906247697804196 17 P16278 1 +Pseudoepiphyses of hand bones 0.4423534795182531 0.2547639853276758 0.7989053931283645 1.0 0.9906247697804196 4 O96028 1 +Pseudoepiphyses 0.4423534795182531 0.2547639853276758 0.7989053931283645 1.0 0.9906247697804196 4 O96028 1 +Pseudoepiphyses of the metacarpals 0.4423534795182531 0.2547639853276758 0.7989053931283645 1.0 0.9906247697804196 4 O96028 1 +Impaired collagen induced platelet aggregation 0.4885807504078314 0.2521847782559086 0.8008982431225202 1.0 0.9920967596813688 2 P27797 1 +Retrognathia 0.276567909592558 0.250556710094254 0.8021568545271363 1.0 0.9927083848834706 65 Q9Y619,Q9UHX1,O75844,P04062,Q15392,Q8WYQ5 6 +Patent ductus arteriosus 0.2764611435677929 0.2493558101732922 0.803085564051095 1.0 0.9930463505978588 70 Q6ZXV5,Q9UHX1,Q15056,Q9UBM7,O75844,P35250,Q6NUK1,Q9Y4P3,Q969G3,Q9NWM8,Q15392,P42892 12 +Abnormal prolactin level 0.4403643301005593 0.2493282061239372 0.8031069147698946 1.0 0.9930463505978588 4 Q969G3 1 +Slender long bone 0.339549202532196 0.2480499916086343 0.8040957274622522 1.0 0.9934400565825536 12 Q9Y619,P37268,Q9Y487,Q96J02 4 +Abnormality of coordination 0.3218695081964735 0.243669423632628 0.8074868560715482 1.0 0.9959605031802726 252 Q9Y619,Q01105,O95721,P35250,P50897,Q9NR77,P16278,P40939,Q5JRX3,O14949,P31483,Q9Y375,Q13501,O75306,P05067,Q8IV08,P07437,Q8WWV3,O75503,Q13510,Q99720,Q99519,Q14108,P41440,P61916,O00584,Q9BVA1,P18074,P00374,P00403,O95831,O43676,Q15067,Q6DKK2,Q9NZ08,O15460,Q15056,P04062,O96028,P35270,Q14738,P35637,Q9Y4P3,Q5XKP0,Q9Y487,O43681 46 +Secondary growth hormone deficiency 0.5200713932247679 0.2415910784913404 0.8090970356794975 1.0 0.9968345929834032 3 Q969G3 1 +Patellar aplasia 0.5197822357764231 0.2409172368773567 0.8096192624576495 1.0 0.9972002221805024 3 Q9Y619 1 +Oculomotor nerve palsy 0.4366961753758982 0.2394417218893283 0.8107630813207798 1.0 0.997486877048002 4 Q969G3 1 +Blistering by anatomical location 0.4832789559543251 0.2391949969818731 0.8109543819158962 1.0 0.997486877048002 2 Q9H4L7 1 +Milia 0.4832789559543251 0.2391949969818731 0.8109543819158962 1.0 0.997486877048002 2 Q9H4L7 1 +Acral blistering 0.4832789559543251 0.2391949969818731 0.8109543819158962 1.0 0.997486877048002 2 Q9H4L7 1 +Azoospermia 0.3438849750305305 0.2379577074201461 0.8119138966565098 1.0 0.997486877048002 11 Q9BZH6,Q13423,P04062,P51809 4 +Decreased absent ankle reflexes 0.3300390663691965 0.2379054495258751 0.8119544287420164 1.0 0.997486877048002 13 Q15120,Q13501,O95140,Q15041 4 +Fatty replacement of skeletal muscle 0.4052690796372426 0.2375269199060685 0.8122480376025059 1.0 0.997486877048002 6 Q8NFF5,P22626 2 +Long philtrum 0.2686386457488721 0.2368682570872431 0.8127589964379305 1.0 0.9977332892714312 94 Q9UHX1,Q15056,O75648,O75718,P07437,P35250,Q14738,Q03164,Q15555,Q9Y4P3,P16278,Q9Y487,Q9UBM7 13 +Exercise intolerance 0.3041486584179294 0.2360064422777747 0.8134276711537214 1.0 0.9982770781112402 25 Q8IUX1,Q8NFF5,P23786,P00403,P40939,Q07021,Q9H2D1,P12235 8 +Distal amyotrophy 0.2873318429759212 0.2339337655810058 0.8150363992517409 1.0 0.9991709011629358 46 P04792,O95140,Q99720,P35637,Q9NR77,Q96BR5,Q15120,Q13510,P31483,Q8N0X7,Q13501 11 +Restless legs 0.4343605358675737 0.233240685782939 0.8155745142419211 1.0 0.9992482206349076 4 O43464 1 +Acute hepatic failure 0.3361536504393342 0.2327569316417664 0.8159501579918178 1.0 0.9994316114089752 12 O75648,Q16836,P40939 3 +Primary adrenal insufficiency 0.3478460567863813 0.2303774926339535 0.8177984490985977 1.0 1.0 10 Q13423,Q9H0R6,Q969G3 3 +Delayed cranial suture closure 0.3028697971790713 0.2291510656931508 0.8187515045334093 1.0 1.0 26 Q8NCH0,O75718,P48651,P16435,O75844,Q9Y487,O75431 7 +Encephalopathy 0.273701283556871 0.2290201599032471 0.8188532471686853 1.0 1.0 78 Q9Y619,O75306,O43772,P04062,P23786,P00403,Q16836,P16219,P40939,O43676,Q9Y375 11 +Camptodactyly of toe 0.4023836080192677 0.2288156229142142 0.8190122235712707 1.0 1.0 6 Q13642,Q14738 2 +Abnormality of alkaline phosphatase level 0.3234547930461791 0.2283299795825185 0.8193897197116142 1.0 1.0 15 Q9UJS0,Q96S52,Q14739,P22626,P09651,Q96AY3,Q13501 7 +Personality changes 0.3231089037978196 0.226562655085952 0.8207638340821428 1.0 1.0 15 P00403,P04062,Q13501 3 +Redundant skin 0.3110192805015612 0.2251904259852661 0.8218311371458855 1.0 1.0 21 Q9Y487,Q15056,Q9Y4P3,P35250 4 +Bone marrow foam cells 0.4308324054370317 0.2240142075298642 0.8227462481417505 1.0 1.0 4 P61916,Q99519 2 +Abnormality of the tonsils 0.4006183618757476 0.2235436613358433 0.823112405897712 1.0 1.0 6 P31751 1 +Wide mouth 0.2782156665973038 0.2227428498640392 0.8237356496631425 1.0 1.0 51 Q01105,Q15056,P55011,P48651,P35250,Q92785,Q9Y4P3,P16278,Q969G3,Q9UM00,P15586,P57081,Q9UBM7 13 +Abnormality of tibia morphology 0.350242416739211 0.2226869609244428 0.8237791502392886 1.0 1.0 9 Q9Y5S9,P16435,O95831 3 +Quadriceps muscle weakness 0.5112144425272875 0.2213994314117386 0.8247814351126304 1.0 1.0 3 O95140 1 +Psychosis 0.3016869834061768 0.2212037073280738 0.8249338227293102 1.0 1.0 26 P61916,O15118,P00403,P16219,Q5JRX3,Q6DKK2,Q8N0X7,Q13501 8 +Coarse hair 0.324475782603035 0.2210862012613548 0.8250253142287167 1.0 1.0 14 P36543,Q6NUK1,P54802,Q9UM00,P15586,Q9Y487,Q96A33 7 +Abnormal urine phosphate concentration 0.4747145187601954 0.2190744640462538 0.8265920423496316 1.0 1.0 2 O14745 1 +Hyperphosphaturia 0.4747145187601954 0.2190744640462538 0.8265920423496316 1.0 1.0 2 O14745 1 +Renal tubular atrophy 0.5095879232966195 0.2177930434165093 0.8275903650172178 1.0 1.0 3 Q96AX1,P57740 2 +Butterfly vertebrae 0.4738988580750508 0.2172144487003928 0.828041225055351 1.0 1.0 2 Q9Y2W2 1 +Abnormal circulating non proteinogenic amino acid concentration 0.3979875856284358 0.2157686594469131 0.8291680790072202 1.0 1.0 6 Q9Y619 1 +Vertigo 0.3093437369155358 0.2151133184884439 0.829678970317687 1.0 1.0 21 Q9NZ08,O15460 2 +Hyperthyroidism 0.3976923209999899 0.2149022036911706 0.8298435667355544 1.0 1.0 6 P21964,P12235 2 +Abnormal circulating estrogen level 0.343865216403227 0.2147195212170713 0.8299860018165994 1.0 1.0 10 Q969G3,P82650,P16435,P51809 4 +Cataplexy 0.5071914437370286 0.2125375913082723 0.8316876539842852 1.0 1.0 3 P61916 1 +Waddling gait 0.3130128616941794 0.2112790867362864 0.8326695009528375 1.0 1.0 18 O75340,Q13510,P22626,Q13642 4 +Aplasia hypoplasia of the skin 0.2783543158434325 0.2068467004571038 0.8361295830639075 1.0 1.0 50 Q9Y619,Q6ZXV5,Q8NCH0,P48651,Q13126,O75844,Q13363,O96028,Q03001,P18074,Q06787,P10644,Q9NWM8,Q15392,P17612,O75431 16 +Vestibular dysfunction 0.3019193576094857 0.2059169445173979 0.8368557892706541 1.0 1.0 24 Q9NZ08,P41440,P06280,O15460 4 +Abnormal circulating gonadotropin concentration 0.3298280598171692 0.2048441866543547 0.8376938629895974 1.0 1.0 12 P16435,P51809,Q969G3,Q06787,P82650 5 +Abnormal shape of the frontal region 0.2723485699821311 0.2045599809864464 0.8379159247029717 1.0 1.0 72 Q9Y619,P16435,P07237,P16278,P15586,Q15392,Q00577,Q14739,P48651,Q99519,Q9Y2U8,P63241,Q13363,P20674,Q15067,Q96J02,Q15233,O75431,P13073,Q9UQR1,O96028,Q14738,Q06787,Q9Y487 24 +Cerebral calcification 0.2983976620503309 0.2045462813194233 0.8379266291491225 1.0 1.0 28 P18074,O00584,P23786,P05067 4 +Adrenal hypoplasia 0.3716279370395298 0.204464934582367 0.8379901912947219 1.0 1.0 7 Q15738,O75844 2 +Cerebral hypoplasia 0.3226440416775517 0.203193776015029 0.838983577385686 1.0 1.0 13 Q9UBM7 1 +Abnormality of the shoulder girdle musculature 0.3010675305174825 0.2004776299875993 0.8411070515430248 1.0 1.0 24 O75340,Q9Y5S9,O14979,Q9Y487,Q13501 5 +Abnormal tracheal morphology 0.296434077336337 0.2001431510275758 0.8413686263978901 1.0 1.0 30 Q9UBM7,Q14739,Q15056,P35250 4 +Oral pharyngeal dysphagia 0.3440759638283202 0.199784833805564 0.8416488630779777 1.0 1.0 9 Q13510 1 +Cranial hyperostosis 0.33990735064777 0.1994337176314193 0.8419234873445693 1.0 1.0 10 P18074,P09651,P22626,P10644 4 +Abnormality of lower limb joint 0.2759271210793415 0.1991418927031596 0.8421517518095802 1.0 1.0 129 Q9Y619,Q9UHX1,Q86XL3,P35250,Q9NR77,P16278,Q6ZXV5,P23786,Q13510,Q8N0X7,Q15738,O75340,O75718,O75844,Q15041,Q9Y5S9,O95831,Q9UBM7,O75431,Q15056,O95140,O96028,Q14738,Q9Y4P3,Q9Y487,Q13642 26 +Abnormality of the optic nerve 0.3051447143443311 0.1968666892010599 0.8439318616853848 1.0 1.0 195 Q8N183,Q9UHX1,P21964,O95721,P06280,P50897,Q9H061,P16278,P10644,P57081,P37198,Q9Y375,O75306,Q6ZXV5,Q8WWV3,Q9BZH6,Q969G3,Q99519,P41440,Q8IUX1,Q8NC96,Q13363,O96019,P18074,Q9HC21,P00403,P16219,O95831,O43676,Q15067,P55011,Q9UBM7,Q9NZ08,O43505,O15460,O95140,Q9UG56,Q96GM8,P61978,P04062,O96028,Q9Y263,Q15555,Q5XKP0,O75648,Q9P032,O43681 47 +Short chin 0.3432578388199313 0.1967973626018702 0.8439861150973167 1.0 1.0 9 O75844,Q96J02,Q03001 3 +Type 1 muscle fiber atrophy 0.3691871577688619 0.1967385315376862 0.8440321555240504 1.0 1.0 7 P61978 1 +Increased circulating lactate dehydrogenase concentration 0.3279296923983459 0.1966195840232354 0.8441252439317184 1.0 1.0 12 P41440,P10253,P23786 3 +Abnormal anterior eye segment morphology 0.3164130580032429 0.1962085033065841 0.8444469727425816 1.0 1.0 238 Q9UHX1,Q06136,P06280,P35250,Q9NR77,P16278,Q14739,Q16134,P07437,Q8WWV3,P23786,Q9NWM8,Q13510,Q8WYQ5,Q99519,P48449,P13804,Q9BVA1,Q13126,O75844,P18074,P10619,P00403,Q9UBM7,Q96EK5,Q9NZ08,Q15056,P04062,O96028,P22626,Q14738,Q15555,Q9Y4P3,O14979,O75648,Q99797 36 +Disproportionate tall stature 0.3003281962037469 0.1957708869033996 0.8447894979982697 1.0 1.0 24 P55011,Q8NCH0,P16435,O96028,Q13363,O96019,Q9NWM8,O75648,Q15031 9 +Abnormality of the female genitalia 0.2626883794346648 0.1957269885618812 0.8448238591413633 1.0 1.0 107 Q9Y619,Q15056,Q96GM8,Q16740,O75874,O75844,Q15392,P35250,Q01844,O96028,P51809,Q9Y4P3,Q6NUK1,P48735,Q9BW83,Q9UBM7 16 +Tetraplegia tetraparesis 0.2894154318981231 0.1946805446134712 0.845643043636827 1.0 1.0 38 P17900,P35637,O95831,Q9UBX3,O43681,Q13501 6 +Memory impairment 0.2946919578668142 0.1938659688594408 0.8462808310388332 1.0 1.0 31 Q9NZ08,P05067,P00403,P31483,O43681,Q13501 6 +Abnormality of the achilles tendon 0.327190827190835 0.1934380447526673 0.8466159226462362 1.0 1.0 12 O60313,Q15041,P50402,Q92734,Q08J23,P02545,Q15149,Q13642,Q9Y3E5,Q9BTV4,Q8WXH0 11 +Abnormality of urine calcium concentration 0.3420392044085808 0.1923700180640157 0.8474523758931185 1.0 1.0 9 Q15056,P35250 2 +Bilateral external ear deformity 0.4973480212158381 0.1916851007337908 0.8479888774596207 1.0 1.0 3 P15924,P14923 2 +Abnormal circulating follicle stimulating hormone concentration 0.3894636602190169 0.1912659080004466 0.8483172694554983 1.0 1.0 6 Q969G3,P51809 2 +Displacement of the urethral meatus 0.2649933396350714 0.1901817826258596 0.849166685954595 1.0 1.0 94 Q9Y619,P48449,Q9UHX1,O75844,O96028,P07437,P51809,Q15555,Q9UBM7,Q96EK5 10 +Periorbital edema 0.2989709814538146 0.1871656279824004 0.8515307734760018 1.0 1.0 24 P28070,Q15056,Q9Y4P3,P35250 4 +Distal upper limb muscle weakness 0.3996552375491388 0.1867598457519929 0.8518489313585711 1.0 1.0 5 Q13501 1 +Patellar dislocation 0.3123158042487267 0.1853539954720508 0.8529513894112875 1.0 1.0 16 Q6ZXV5,Q15056,P35250,Q9Y5S9,Q9Y4P3 5 +Abnormal circulating nitrogen compound concentration 0.2866886288224725 0.1852810884444696 0.8530085704519288 1.0 1.0 41 Q9Y619,O43772,P23786,Q16836,P40939 5 +Neoplasm by histology 0.2691086219518079 0.1802295070687871 0.8569723944212146 1.0 1.0 80 Q13126,O75874,Q92804,P07437,P51809,Q01844,P18074,Q15555,Q02978,P48735,Q15392,Q13501 12 +Abnormal cell morphology 0.4916360669114665 0.1801325606296228 0.857048500998979 1.0 1.0 3 O95453,P15924 2 +Onion bulb formation 0.3846871762780536 0.1780081538412667 0.8587165721740011 1.0 1.0 6 Q9NR77 1 +Pace of progression 0.2770737495512242 0.1774701163388769 0.8591391363370113 1.0 1.0 134 Q14108,P41440,Q9BUF5,Q9NR28,P04792,Q13126,Q8IV08,P04062,Q9NR77,O95831,Q5XKP0,O14979,Q15120,Q13510,Q99720,Q13501 16 +Abnormality of acid base homeostasis 0.2812527221753143 0.1771354058975376 0.8594020317574365 1.0 1.0 142 Q9Y619,P40939,P48735,O14949,Q9Y375,O75306,Q16134,P23786,P13804,P00403,Q16836,P16219,O95831,O43676,P20674,Q70HW3,P22695,Q5XKP0,O75648,Q9H0R6,Q99797 21 +Abnormal facial expression 0.2991383711077631 0.1754533329891659 0.8607234367880363 1.0 1.0 23 P04062,P35270 2 +Supernumerary nipple 0.3404974840457327 0.174531128790708 0.861448068936733 1.0 1.0 8 Q9UM00,Q14738 2 +Neurogenic bladder 0.4887800897592845 0.1745087047387835 0.8614656903385582 1.0 1.0 3 O76024,P83436 2 +Insomnia 0.3146275649214385 0.1739770480298847 0.8618835001544078 1.0 1.0 14 Q15056,Q9Y4P3,P35250 3 +Inappropriate behavior 0.3158240756889557 0.1721839362841635 0.8632929262611237 1.0 1.0 13 P17900 1 +Abnormal basal ganglia mri signal intensity 0.3004308148949475 0.1721631906686797 0.8633092353361298 1.0 1.0 22 O75306,O75340,P16278,Q8N183 4 +Limb girdle muscle weakness 0.3065939716814256 0.1709405131208615 0.8642705406012574 1.0 1.0 17 Q13126 1 +Tremor 0.2754765902072753 0.1704643892332711 0.8646449377253438 1.0 1.0 132 P35250,Q9NR77,Q15120,Q5JRX3,Q13501,O75306,P31930,O43464,O75503,Q13510,Q99720,Q99519,Q14108,P41440,P18074,O95831,Q6DKK2,Q15056,P04062,P35270,P35637,Q9Y4P3,O43681 23 +Excessive daytime somnolence 0.3356256871736216 0.1695249774253852 0.865383727537554 1.0 1.0 9 Q9UBM7 1 +Abnormality of the cervical spine 0.2684585889958297 0.1683300829325258 0.8663236087563624 1.0 1.0 78 Q9UHX1,P07437,P18074,O95831,P16278,Q9BW83,Q9UBM7,Q96EK5 8 +Abnormal saccadic eye movements 0.3060256145477223 0.1679330276658655 0.8666359667709971 1.0 1.0 17 O75306,O95140,Q8IV08,P04062,Q10713,O14773 6 +Abnormal cardiac ventricle morphology 0.2825685852474698 0.1674274695219118 0.8670337126707754 1.0 1.0 146 Q9UHX1,P06280,P35250,Q6NUK1,P40939,P42892,Q14739,O75306,O43772,P23786,Q969G3,Q8WYQ5,Q15738,O75844,P18074,P00403,Q9Y5S9,Q9UBM7,O75431,Q15056,P61978,O96028,Q14738,Q9Y4P3,Q13642,P10253,Q8N183 27 +Ambiguous genitalia 0.308643744387698 0.1666280555806681 0.8676627171453704 1.0 1.0 16 Q9UBM7,Q15392,Q96GM8 3 +Abnormal dermoepidermal junction morphology 0.4834761321909493 0.1643356270851375 0.8694669365736267 1.0 1.0 3 P15924,P14923 2 +Abnormal sclera morphology 0.2988427380176433 0.162723300092019 0.8707363006807787 1.0 1.0 22 O75718,Q96AY3,P07237,Q96EK5,P40939,P10644,Q9Y3B2 7 +Typical absence seizure 0.3299790675147759 0.1623870901139791 0.8710010365069663 1.0 1.0 10 Q01105,Q13510 2 +Recurrent respiratory infections 0.261746369922374 0.1615545962356094 0.8716566144554869 1.0 1.0 96 O15460,Q15056,P04062,O96028,P35250,P18074,Q9Y4P3,P16278,P09601,Q9Y487,Q13510,P10253 12 +Pancreatitis 0.3119476796668462 0.1615257763192184 0.8716793113411796 1.0 1.0 14 Q9NZ08,P00403,Q4G0N4 3 +Eeg with abnormally slow frequencies 0.3119423115131256 0.1615009999194661 0.8716988238734029 1.0 1.0 14 O75503 1 +Profound hearing impairment 0.3890828389288177 0.1601978970869841 0.8727251858833334 1.0 1.0 5 Q9NR77 1 +Abnormal circulating igg level 0.3186335030711517 0.1574175526871838 0.8749157808725221 1.0 1.0 12 P18074,Q15904 2 +Glomerular sclerosis 0.2912502519086674 0.1562371256869918 0.875846113978175 1.0 1.0 28 Q02978,P00403,Q14108,Q8NFH4 4 +Abnormal lymphocyte morphology 0.2918119962978643 0.1562017349403283 0.8758740092382438 1.0 1.0 26 P28070,P16278 2 +Hyperpigmentation of the skin 0.2679872125781789 0.1559744283632193 0.8760531777137059 1.0 1.0 72 Q06136,O75844,P04062,P07437,P18074,Q15555,Q14739 7 +Neoplasm of fatty tissue 0.3858717844017993 0.15247054275059 0.8788158222552054 1.0 1.0 5 Q6P1J9,Q9Y2U8,O95140,P27635 4 +Fibrous tissue neoplasm 0.3080074609093811 0.1519036829474573 0.8792629034348121 1.0 1.0 15 Q13126,Q15392,Q969G3 3 +Achilles tendon contracture 0.3269230769230815 0.1513737537841983 0.879680892314626 1.0 1.0 10 O60313,P50402,Q08J23,P02545,Q15149,Q13642,Q9Y3E5,Q9BTV4,Q8WXH0 9 +Hepatic encephalopathy 0.4757567265622483 0.1501629957010634 0.8806360199619341 1.0 1.0 3 Q9UJS0 1 +Abnormality of skeletal maturation 0.2672748883445921 0.1493862711316002 0.8812488442244026 1.0 1.0 74 Q9Y619,P35250,Q6NUK1,P10644,P57081,P48651,Q9BZH6,Q969G3,Q99519,Q14108,P48449,Q13363,P18074,O95831,Q96J02,Q15056,O96028,P51809,P04062,Q03164,Q9Y4P3 21 +Abnormal drinking behavior 0.4749082007344022 0.1486510760296331 0.8818289678634754 1.0 1.0 3 O76024,Q8N5K1 2 +Hepatic fibrosis 0.2905269817370312 0.1475594419300104 0.8826904652664915 1.0 1.0 25 Q13510,P04062,Q15904 3 +Congenital malformation of the left heart 0.4740922072623489 0.1472057212221676 0.8829696449134237 1.0 1.0 3 Q9UQR1,O14802 2 +Specific learning disability 0.2720175770392617 0.146956710124072 0.8831661895706961 1.0 1.0 50 Q9Y619,O43505,P21964,Q9BVA1,P22626,P35637,P09651,P00403,P10644,Q96EK5,Q8WYQ5,Q8N0X7,Q13501 13 +Abnormality of the abdominal organs 0.3178499275377072 0.146845887933161 0.8832536639274085 1.0 1.0 273 Q9Y619,P28070,Q9UHX1,Q8N183,P21964,P35250,Q01844,P31751,P09651,P16278,P09601,P40939,O75880,P10644,Q15392,Q15904,Q9Y375,Q14739,O75306,O43772,Q16134,Q8NFH4,P23786,Q969G3,Q13510,Q99519,Q14108,P61916,P13804,O75340,P00374,P10619,Q16836,P00403,P16219,O43676,P20674,Q15067,Q9Y5S9,Q9BW83,Q9UBM7,Q96J02,Q00059,O75431,Q9NZ08,O15118,Q15056,O95140,P04062,O96028,P22626,P54802,Q9Y4P3,Q9P032,Q5XKP0,O75648,P10253,O43681 58 +Arthrogryposis multiplex congenita 0.2899247753665275 0.1452810571719316 0.8844889702290486 1.0 1.0 27 P04062,Q15392,O75844 3 +Carious teeth 0.2827731221526162 0.1424349170643473 0.886736483708094 1.0 1.0 38 Q15056,P35250,P18074,Q15555,P16278,Q9Y487 6 +Hyposmia 0.3147946466960073 0.1417731553876417 0.8872591887528765 1.0 1.0 12 Q9BW83,P04062,O43464 3 +Kinetic tremor 0.2893759083441068 0.1417131094283211 0.8873066196259383 1.0 1.0 27 Q14108,P41440,O43681 3 +Spastic paraplegia 0.2818704619248707 0.1413816846096296 0.8875684224924598 1.0 1.0 40 Q9Y619,O75306,Q96GM8,Q15041,P04062,O95831,Q8N0X7 7 +Blue sclerae 0.3006262967651292 0.1397582558551667 0.8888509965090372 1.0 1.0 17 O75718,Q96AY3,P07237,Q9Y3B2,Q96EK5 5 +Abnormality of globe size 0.2807076601978973 0.136410973389968 0.8914963992565983 1.0 1.0 41 O43505,Q9UHX1,P07437,Q6NUK1,P18074,Q15555,O75431 7 +Connective tissue nevi 0.4676480534829678 0.1360876570472998 0.8917519849985105 1.0 1.0 3 Q6NUK1 1 +Conjugated hyperbilirubinemia 0.4323001631321383 0.13561143249328 0.892128467128952 1.0 1.0 2 Q9H267 1 +Angular cheilitis 0.4298531810766887 0.131624840952878 0.8952810362330834 1.0 1.0 2 P20810 1 +Abnormality of the nasal skeleton 0.3903560596554777 0.1309170977635441 0.8958408890342453 1.0 1.0 4 Q6NUK1 1 +Abnormal pulmonary valve morphology 0.3662526662270537 0.130175398277086 0.8964276582711679 1.0 1.0 6 P21964 1 +Alopecia universalis 0.4282218597063644 0.1290168711505104 0.8973442991525169 1.0 1.0 2 P15924 1 +Axial muscle weakness 0.4282218597063635 0.1290168711505093 0.8973442991525178 1.0 1.0 2 Q9Y281 1 +Dysmenorrhea 0.4282218597063609 0.1290168711505048 0.8973442991525213 1.0 1.0 2 O00170 1 +Deformed sella turcica 0.3890181203495533 0.1282559263329386 0.8979464426617163 1.0 1.0 4 P08236,O75431 2 +J shaped sella turcica 0.3890181203495533 0.1282559263329386 0.8979464426617163 1.0 1.0 4 P08236,O75431 2 +Facial hypotonia 0.3227133955853745 0.125963813400633 0.8997605690852439 1.0 1.0 9 P10253 1 +Protruding tongue 0.3226744688151234 0.1258376055118398 0.8998604734734605 1.0 1.0 9 Q99519 1 +Aplasia hypoplasia of the gallbladder 0.425774877650898 0.1251792938652224 0.9003816093933259 1.0 1.0 2 A5YKK6 1 +Abnormal blood inorganic cation concentration 0.2863940288833615 0.1242246165161039 0.9011374320369114 1.0 1.0 28 P21964,Q15056,P35250,Q02978,Q9Y4P3,P40939,Q8WYQ5 7 +Dilated fourth ventricle 0.2847341797371585 0.1240588794270101 0.9012686560375678 1.0 1.0 31 Q9Y487,Q9UBM7,P07437 3 +Meningioma 0.3857142857142812 0.1218014722290854 0.9030562479633876 1.0 1.0 4 P02545,Q969G3,Q12824 3 +Neurofibromas 0.3857142857142808 0.1218014722290846 0.9030562479633883 1.0 1.0 4 Q969G3,Q12824,Q01082 3 +Primitive neuroectodermal tumor 0.3182863753131245 0.1212916532531759 0.903460030947962 1.0 1.0 10 P07437 1 +Thick eyebrow 0.2796197388897021 0.1203418797170046 0.904212329937939 1.0 1.0 39 Q9UHX1,Q6NUK1,Q03164,O95831,Q969G3,Q96EK5 6 +Pituitary growth hormone cell adenoma 0.4577082011263217 0.119969623005633 0.9045072114554122 1.0 1.0 3 P10644 1 +Poikiloderma 0.3714673889876822 0.119807771288792 0.904635425691513 1.0 1.0 5 P18074 1 +Glucose intolerance 0.2605769004823554 0.1180839652318179 0.906001128447174 1.0 1.0 91 Q06136,P35250,P31751,P10644,Q9Y375,O75306,Q9Y3E5,Q8IUX1,O75844,P00403,O43676,Q96J02,P12235,O75431,Q15056,P17096,Q9NPL8,Q15555,Q9Y4P3,Q9P032,Q8N183 21 +Juvenile onset 0.2792357651476961 0.117357281506004 0.906576934503255 1.0 1.0 39 P06280,Q13510,P16278,Q9NR77 4 +Ovarian cyst 0.3021281545504448 0.1173549580771917 0.9065787756092014 1.0 1.0 14 P31751,Q15056,Q9Y4P3,P35250 4 +Abnormality of skin adnexa physiology 0.2829100722762772 0.1170553634835786 0.9068161812695412 1.0 1.0 32 O15460,P61978,P06280,P35270,Q02978 5 +Abnormal csf metabolite level 0.2740212474382921 0.1161384014966998 0.9075428547282413 1.0 1.0 46 Q8IUX1,O75306,Q8N183,Q9HC21,O43464,P00403,O95831,O43676,Q9P032,Q9Y375 10 +Hoarse voice 0.2874287734010077 0.1159534257405454 0.9076894535991528 1.0 1.0 24 Q15056,P35250,Q9Y4P3,Q13510,Q8N0X7 5 +Athetosis 0.3127896572146031 0.1155117340794148 0.90803952028373 1.0 1.0 11 O14949 1 +Recurrent bronchopulmonary infections 0.3693217314758645 0.1152265042592903 0.9082655912293984 1.0 1.0 5 P18074 1 +Localized skin lesion 0.2910212570111825 0.114114820445433 0.9091467739541093 1.0 1.0 173 Q9Y619,Q9UHX1,Q06136,P06280,P35250,P48735,Q15392,Q14739,O75874,Q9NWM8,Q13510,Q13126,O75844,P18074,Q9NZ08,O15460,Q15056,P04062,O96028,P35637,Q03164,Q15555,Q9Y4P3 23 +Protruding ear 0.2792558582586604 0.1140309940318626 0.9092132240008493 1.0 1.0 37 O43505,Q15056,Q06136,P35250,P18074,Q9Y4P3 6 +Functional abnormality of male internal genitalia 0.2851152715349485 0.1138083075872639 0.909389752883818 1.0 1.0 25 Q15056,P16435,P04062,P51809,P35250,Q9BZH6,Q13423,Q9Y4P3 8 +Abnormality of female external genitalia 0.2849645703296717 0.1133600828804497 0.9097450849104892 1.0 1.0 27 Q9Y619,Q96GM8,Q15392,P51809,Q9UBM7 5 +Leukonychia 0.367088607594937 0.1105375815292525 0.9119830467192034 1.0 1.0 5 P20810,P52732,P15924,O15446 4 +Abnormality of nail color 0.367088607594937 0.1105375815292525 0.9119830467192034 1.0 1.0 5 P20810,P52732,P15924,O15446 4 +Reduced tendon reflexes 0.2682658483116222 0.1103061485877617 0.912166581155382 1.0 1.0 127 P04792,O95721,Q03001,Q9NR77,P40939,Q15120,Q9Y3B2,Q13501,O60701,Q96BR5,Q13510,Q99720,Q9Y3E5,P41440,O75340,Q8NC96,Q15041,Q9HC21,P18074,O95831,Q15067,P12235,O43505,O95140,P61978,P04062,Q14738,P35637,P54802,Q06787,O14979,P61981,O75648,Q13642,P10253,Q96AY3,O43681 37 +Abnormal blood phosphate concentration 0.3666802776643573 0.1096889486161882 0.9126560652536392 1.0 1.0 5 Q6P1J9,O14745,Q15813,P10644 4 +Thickened nuchal skin fold 0.3570636043984205 0.1083887770164202 0.9136873033302576 1.0 1.0 6 Q13501 1 +Impaired pain sensation 0.2943154432038851 0.1077803071308724 0.9141699645115776 1.0 1.0 17 O95140,Q9NR77,P04792,O95831 4 +Arnold chiari malformation 0.2998350360150526 0.1073844841760556 0.9144839631602985 1.0 1.0 14 Q15056,P35250 2 +Abnormal internal genitalia 0.2547111398546849 0.1060015701327581 0.9155811064210256 1.0 1.0 101 Q15056,Q96GM8,Q16740,O75874,O75844,O96028,P35250,Q01844,P18074,P51809,P48735,Q9BW83,Q9UBM7 13 +Hypoplastic toenails 0.2885426390172098 0.1031494388327109 0.9178443677374236 1.0 1.0 22 Q15056,P23786,Q14738,P35250,Q9Y4P3 5 +Chorioretinal coloboma 0.4102773246329582 0.1029194128511638 0.9180269302893376 1.0 1.0 2 Q10713 1 +Tapered distal phalanges of finger 0.4102773246329545 0.1029194128511591 0.9180269302893412 1.0 1.0 2 P15924 1 +Diarrhea 0.2601980334442937 0.1023365424723361 0.918489550856764 1.0 1.0 54 P06280,O43464,P18074,Q14738,Q13423,P00403,Q16836,P40939,P54802,Q96J02,Q13510,Q15904,P42892 13 +Abnormality of dental morphology 0.2601591625545747 0.1019536483474483 0.918793466552319 1.0 1.0 54 Q9Y619,Q9Y487,Q15056,O96019,Q6NUK1,P35250,P07237,Q15555,Q9Y4P3,O75648,Q9UBM7 11 +Abnormal scapula morphology 0.2756149150283711 0.1003338406678062 0.9200792920677614 1.0 1.0 42 Q9Y619,Q15738,O75340,Q9UM00,Q9Y487,Q14739,Q13501 7 +Abnormal eyelash morphology 0.2628999428352225 0.1002905789866054 0.9201136366629176 1.0 1.0 70 P48449,Q9UHX1,O75844,Q03164,Q9UBM7 5 +High forehead 0.2626605621430109 0.0975248307796622 0.9223096161055662 1.0 1.0 71 P35250,P57081,Q9Y3B2,Q15904,Q14739,Q16134,P23786,Q99519,Q8NC96,P13804,Q13363,O96019,Q9Y5S9,O75431,Q15056,O96028,Q03164,Q9Y4P3,O75648 19 +Joint contractures involving the joints of the feet 0.313546495351198 0.0971274833461945 0.9226251554867386 1.0 1.0 9 Q13642,P63241,Q14738 3 +Dilation of lateral ventricles 0.2908538702932987 0.0971062408740839 0.9226420247864342 1.0 1.0 19 Q01105,Q9BVA1,Q14738 3 +Abnormal adipose tissue morphology 0.2728173519971116 0.0970589884526103 0.922679549510756 1.0 1.0 45 P28070,O95140,O75844,Q6NUK1,P31751,P18074,Q9Y487,O75431 8 +Woolly hair 0.3602253548971467 0.0966340028403505 0.9230170524883876 1.0 1.0 5 Q6PGP7,Q96A33,P14923 3 +Aortic aneurysm 0.2725632205040165 0.0949229283820603 0.9243760445320794 1.0 1.0 45 Q6ZXV5,O15460,Q15056,O75844,O96019,Q6NUK1,P35250,Q9Y4P3,O75648 9 +Dysarthria 0.2671130855240074 0.0948081299487072 0.9244672291983131 1.0 1.0 127 Q13409,P35250,Q13501,O75306,P07737,Q8IV08,O75503,Q14108,P41440,P61916,P18074,Q6DKK2,Q15056,P04062,P35270,P35637,Q9Y4P3,Q5XKP0,O43681 19 +Cranial nerve compression 0.3127372678237299 0.0946686445899639 0.9245780240829876 1.0 1.0 9 Q02978,P22626 2 +Abnormal fundus autofluorescence imaging 0.4033442088091362 0.0940794730011228 0.9250460262213558 1.0 1.0 2 Q8WWY3 1 +Abnormality of the musculature of the thigh 0.3137290607704127 0.0915543207226292 0.9270521457333144 1.0 1.0 8 O14979 1 +Tritanomaly 0.436964504283965 0.0903266293303488 0.9280276594956848 1.0 1.0 3 O00429,O60313 2 +Anomalous trichromacy 0.436964504283965 0.0903266293303488 0.9280276594956848 1.0 1.0 3 O00429,O60313 2 +Acantholysis 0.3669387755101999 0.0882906530247447 0.9296456677500736 1.0 1.0 4 P01889,P15924,P14923 3 +Gonadal dysgenesis 0.3081715091893842 0.0881106827988268 0.9297887057591596 1.0 1.0 10 P18074,Q96GM8 2 +Abnormal conus terminalis morphology 0.3466183014129047 0.0853438689535054 0.9319880163477215 1.0 1.0 6 O96028 1 +Anteriorly placed anus 0.3071457186496257 0.0848737576134041 0.9323617548808518 1.0 1.0 10 P48651,Q6NUK1,P16435 3 +Ectopic anus 0.3071457186496257 0.0848737576134041 0.9323617548808518 1.0 1.0 10 P48651,Q6NUK1,P16435 3 +Cheilitis 0.430028559771525 0.0815971655145909 0.934967055371609 1.0 1.0 3 P20810,P54132 2 +Sagittal craniosynostosis 0.3619377728173568 0.0802721398313354 0.9360208158861733 1.0 1.0 4 P61978 1 +Dilatation of the cerebral artery 0.3095970971240964 0.0800603960944623 0.9361892209354864 1.0 1.0 8 P10253 1 +Acute pancreatitis 0.4283965728274197 0.0796273941586581 0.9365336070020044 1.0 1.0 3 P35914,Q96MF7 2 +Progressive pes cavus 0.4275428973776419 0.0786096948234502 0.9373430760507804 1.0 1.0 3 Q13642 1 +Prominent forehead 0.2591636252253372 0.0774629658821074 0.9382552516622792 1.0 1.0 59 Q9UHX1,P23786,Q14738,P11233,Q15392,Q14739 6 +Aplasia hypoplasia involving bones of the feet 0.2628792410268007 0.0769715648762797 0.938646165781242 1.0 1.0 51 Q9UBM7,Q13510,Q9UHX1 3 +Hypoplastic fifth toenail 0.3084562238715386 0.0769514969076732 0.938662130353782 1.0 1.0 8 Q969G3,Q14738 2 +Submucous cleft soft palate 0.4259485924112559 0.0767322653938112 0.9388365361280696 1.0 1.0 3 Q15233,O14802 2 +Right bundle branch block 0.342318738984158 0.0763975708967318 0.9391028021033028 1.0 1.0 6 P04899,P14923 2 +Abnormal endocrine physiology 0.3585194367411741 0.0750091159427011 0.9402074588546456 1.0 1.0 4 Q13423 1 +Abnormality of hand joint mobility 0.4241339662026305 0.0746320003340059 0.9405075125305418 1.0 1.0 3 Q9Y263 1 +Hyperextensibility of the finger joints 0.4241339662026305 0.0746320003340059 0.9405075125305418 1.0 1.0 3 Q9Y263 1 +Down sloping shoulders 0.2855504274485856 0.0741760639757005 0.9408702915522944 1.0 1.0 20 O75648,Q15056,Q9Y4P3,P35250 4 +Thoracic aortic aneurysm 0.2780449488325178 0.070897132486229 0.9434796255790544 1.0 1.0 28 Q15056,O75844,P35250,Q9Y4P3,O75648 5 +Abnormal fingernail morphology 0.2731591127542507 0.070821279013729 0.9435399961421088 1.0 1.0 39 Q15056,O75844,P35250,P18074,Q9Y4P3,Q969G3,Q14739 7 +Abnormal nasal mucosa morphology 0.4207046619870246 0.0707685227974774 0.9435819841603365 1.0 1.0 3 Q03519 1 +Abnormal response to endocrine stimulation test 0.4195397591859749 0.0694873384771455 0.9446017107238608 1.0 1.0 3 Q13423 1 +Absent septum pellucidum 0.2775103836748425 0.06756165753233 0.9461345784822894 1.0 1.0 28 O43505,P48651,Q13409,Q96C86,Q13363,O96028,Q9BZH6,Q15392 8 +Papilledema 0.2859541333023108 0.0671174503027225 0.9464882018869792 1.0 1.0 17 O75648,P04062,Q969G3 3 +Phocomelia 0.4164976783684763 0.0662155175355979 0.947206242680771 1.0 1.0 3 Q9Y5S9 1 +Anal stenosis 0.3764274061990204 0.0659092486160744 0.9474500772650774 1.0 1.0 2 Q12948 1 +Abnormality of primary teeth 0.2983290953276526 0.0657702404413218 0.94756074960609 1.0 1.0 11 O75844,Q9UM00 2 +Abnormal sperm motility 0.3760195758564403 0.0655533778333817 0.9477334083242488 1.0 1.0 2 Q86Y56 1 +Distal lower limb muscle weakness 0.2942654398263981 0.0640188700585084 0.948955201493516 1.0 1.0 12 P04792 1 +Nephrolithiasis 0.2849322215687342 0.062288320166312 0.9503332295732464 1.0 1.0 17 Q15056,P35250 2 +Concave nasal ridge 0.367047308319738 0.0582209088756739 0.953572666095552 1.0 1.0 2 Q12948 1 +Hemiplegia hemiparesis 0.2759856811873544 0.0575561271803754 0.9541021971424852 1.0 1.0 27 Q9NZ08,P00403,Q9BVA1 3 +Female infertility 0.3633768352365379 0.0554865872644189 0.9557508153009406 1.0 1.0 2 Q86Y56 1 +Short nose 0.25850600255183 0.053879476429378 0.9570311883468758 1.0 1.0 76 Q9UHX1,Q15056,O75844,P04062,P35250,Q6NUK1,Q14738,Q03164,Q9Y4P3,Q969G3,Q9UM00,Q9Y487,Q15392,P42892 14 +Limb girdle muscle atrophy 0.2911069901967794 0.0529976959900836 0.9577337434689948 1.0 1.0 12 Q13642,O14979 2 +Profound global developmental delay 0.2981573517042979 0.0528651394799929 0.9578393602030224 1.0 1.0 9 P55011,P57081 2 +Muscular ventricular septal defect 0.3998368013055873 0.0501385058793464 0.9600120150564082 1.0 1.0 3 Q9Y2W2,Q5SRE5 2 +Inverted nipples 0.3333825972810761 0.0496400677108197 0.960409216558243 1.0 1.0 5 Q15067 1 +Chordee 0.3282872379705425 0.0494115598358288 0.9605913159990024 1.0 1.0 6 P48651,P16435 2 +Freckling 0.3330165497424974 0.0490800760462257 0.960855481281096 1.0 1.0 5 P18074 1 +Abnormality of the supraorbital ridges 0.2813440868488584 0.0468550558907369 0.9626287489267618 1.0 1.0 18 P38159,P16435,Q6NUK1,Q13642,Q99519 5 +Accelerated skeletal maturation 0.2968090779652241 0.0468411681194948 0.9626398176118788 1.0 1.0 8 Q03164 1 +Genetic anticipation 0.3491027732463253 0.0462158204305314 0.9631382330678177 1.0 1.0 2 Q9UBB4 1 +Sparse scalp hair 0.27365932450171 0.0435471856341666 0.965265351480711 1.0 1.0 27 Q6NUK1,P48449,Q96EK5,P18074 4 +Fetal ultrasound soft marker 0.2947873793151365 0.0419203858779765 0.96656216510082 1.0 1.0 8 Q13501,P61978 2 +Difficulty climbing stairs 0.2900346291077861 0.0395452398087463 0.9684556855540228 1.0 1.0 11 O75340,O95140,P40939 3 +Hypersomnia 0.3344208809135371 0.0387269449184692 0.9691080905808408 1.0 1.0 2 O00170 1 +Emg abnormality 0.2542945064403077 0.0382054432030399 0.9695238810177268 1.0 1.0 56 O75340,P04792,O95140,P22626,Q13642,Q9NR77,Q15120,Q13510,P31483,O43681,Q13501 11 +Abnormality of metacarpophalangeal joint 0.3301726382894856 0.0380044364963894 0.9696841447726668 1.0 1.0 4 P16435,Q15233 2 +Intrauterine growth retardation 0.2764442252245682 0.0374462604360662 0.9701291880217262 1.0 1.0 153 Q9Y619,Q9UHX1,P21964,P07237,Q6NUK1,P16278,P40939,O75880,P10644,P57081,Q15392,Q9Y375,O75306,P48651,Q969G3,Q15738,Q8IUX1,O75844,Q13363,P18074,Q92785,Q16836,P16219,O43676,P37268,Q9UBM7,Q00059,P04062,O96028,Q03164,Q9Y487,Q9H0R6,Q9P032,Q8N183 34 +Hiatus hernia 0.3077237433592167 0.0370981130299676 0.9704067765783352 1.0 1.0 7 Q8NBU5,Q8NCH0,Q8WUM0,P57740,P57081,P54886 6 +Aplasia hypoplasia of the scapulae 0.382734135103091 0.0366843387337051 0.9707366961181568 1.0 1.0 3 Q15738 1 +Abnormal emotion affect behavior 0.289789965434592 0.0366349336996093 0.9707760891524688 1.0 1.0 184 Q01105,Q9UHX1,Q13409,Q92804,P50897,Q13501,O75306,O43772,P07737,Q8NFH4,O43464,Q15165,Q969G3,O75503,Q13510,Q8WYQ5,Q8N0X7,O95831,Q15067,Q9UBM7,Q6DKK2,Q9NZ08,P17900,P04062,P35270,Q14738,P35637,Q03164,O43681 29 +Increased blood pressure 0.254691794548508 0.0359601506208184 0.9713141335860732 1.0 1.0 58 P21964,Q15056,P06280,O75844,P04062,P35250,Q02978,P00403,Q9Y4P3,Q96J02,Q9BW83,P42892 12 +Abnormal nervous system electrophysiology 0.2697301002258837 0.0351954152269586 0.9719239180868366 1.0 1.0 140 Q9Y619,P04792,O95721,P50897,Q9NR77,Q9BQE5,Q15120,Q13501,P31930,O75503,Q99720,Q99519,Q14108,P48449,P18074,P00403,O95831,Q15067,O96028,O43681 20 +Hyperostosis 0.2857155050036803 0.0347985078348055 0.9722404104877302 1.0 1.0 12 P18074,P09651,P22626,P10644 4 +Neoplasm of the tongue 0.3259962297363611 0.033516787210274 0.9732624790947764 1.0 1.0 4 Q969G3 1 +Inflammatory abnormality of the eye 0.2689009634241246 0.0331249185385606 0.973574971530708 1.0 1.0 34 Q9NZ08,P28070,Q14739 3 +Recurrent acute respiratory tract infection 0.3769889840881241 0.0328055371498733 0.9738296625838848 1.0 1.0 3 Q15149,Q03519 2 +Adrenal overactivity 0.3767657846148047 0.0326610104283932 0.973944916461559 1.0 1.0 3 P10644 1 +Increased circulating cortisol level 0.3767657846148047 0.0326610104283932 0.973944916461559 1.0 1.0 3 P10644 1 +Abnormal dentin morphology 0.3240816326530565 0.031538434739621 0.9748401408900228 1.0 1.0 4 P50454,Q96AY3,P23284 3 +Pneumothorax 0.3174288184735674 0.0308511558579635 0.9753882433395652 1.0 1.0 6 Q8NCH0,Q6NUK1 2 +Cutaneous syndactyly 0.2899870562307582 0.0306029085663816 0.9755862225371276 1.0 1.0 8 Q9Y619,P98175 2 +Abnormality of the voice 0.2490728056447441 0.030544470325764 0.9756328277198704 1.0 1.0 105 Q13409,P35250,P07237,Q9NR77,Q02978,Q13510,Q8WYQ5,Q8N0X7,Q99519,O75844,O96019,P18074,Q6DKK2,O75431,Q9Y487,Q15056,O95140,P04062,Q9Y4P3,O75648,Q13642 21 +Hyporeflexia 0.2521785546802567 0.0296454560627421 0.9763498125335994 1.0 1.0 94 P04792,Q9NR77,P40939,Q15120,Q9Y3B2,Q13501,Q96BR5,Q99720,Q9Y3E5,P41440,Q8NC96,Q9HC21,P18074,O95831,Q15067,P12235,O43505,O95140,P04062,P35637,P54802,Q06787,O14979,O75648,Q13642,O43681 26 +Hand oligodactyly 0.3070962479608484 0.0292899531340957 0.9766333397036796 1.0 1.0 2 Q15427 1 +Onycholysis 0.3171837691011592 0.0268908121387165 0.9785468217201708 1.0 1.0 5 P10321 1 +Hypophosphatemia 0.3663810689514462 0.026425644629343 0.9789178398332404 1.0 1.0 3 Q6P1J9,O14745 2 +Decreased facial expression 0.2763617708118899 0.0251989271438063 0.9798962927008834 1.0 1.0 19 P04062,P35270,Q9Y263,Q06787,P12235 5 +Breathing dysregulation 0.2773246329526873 0.0238164121803388 0.9809990487358812 1.0 1.0 2 Q10713 1 +Open mouth 0.2698303950007673 0.0235326008918621 0.981225433929046 1.0 1.0 25 P61978,Q86XL3,P04062,Q03001,Q14738,Q10713,P10644,Q00577,Q8WYQ5,Q15233 10 +Accessory oral frenulum 0.2699836867862926 0.0229980849874665 0.9816518005049404 1.0 1.0 2 P17612 1 +Underdeveloped tragus 0.2699836867862922 0.0229980849874665 0.9816518005049404 1.0 1.0 2 Q5SRE5 1 +Dysgenesis of the cerebellar vermis 0.2679445350734051 0.0227992597493515 0.9818103985066506 1.0 1.0 2 Q10713 1 +Abnormality of dental structure 0.2545533065830378 0.0221961877383535 0.9822914585868876 1.0 1.0 63 Q15056,O75844,P35250,P18074,Q15555,Q9Y4P3,P16278,Q9Y487,Q9UBM7 9 +Abnormal venous morphology 0.2754862728968788 0.0210709433385001 0.9831890636041568 1.0 1.0 19 P21964,P98175,P36543,P48651,P04062,Q6NUK1,Q9Y487 7 +Sandal gap 0.2754551898857576 0.0194941020214854 0.9844469420554612 1.0 1.0 18 Q969G3,O75431,Q14739 3 +Tremor by anatomical site 0.2690751765839609 0.0192847300152203 0.9846139653473108 1.0 1.0 25 P35637,Q9NR77,Q15120 3 +Lactic acidosis 0.2552715540954826 0.0189056857468657 0.9849163437823912 1.0 1.0 71 O75306,P00403,Q16836,P40939,O43676,Q5XKP0,O75648,Q99797,Q9Y375,Q70HW3 10 +Choanal stenosis 0.3507993121270241 0.0187390093574893 0.9850493087444204 1.0 1.0 3 P48651 1 +Genital neoplasm 0.269289748976991 0.018187983338281 0.9854888889592002 1.0 1.0 29 Q01844,P48735,O75874 3 +Pollakisuria 0.3492452060383508 0.0180732827700644 0.9855803917310204 1.0 1.0 3 Q8WVX9,Q06787 2 +Heteronymous hemianopia 0.3087033045465884 0.0173789934437509 0.986134267428962 1.0 1.0 4 Q969G3 1 +Functional abnormality of the inner ear 0.2957010464096836 0.0170894060301014 0.9863652904430056 1.0 1.0 205 Q9NR28,O95721,Q16740,P06280,P35250,Q9NR77,Q9H061,Q15120,Q15904,Q9Y375,Q13501,O75306,Q9NWM8,Q13510,Q99519,P41440,O00584,O75844,P18074,P00403,O95831,O43676,Q15067,Q9UBM7,Q9NZ08,O15460,Q15056,Q9UG56,P04062,O96028,P35637,Q15555,Q5XKP0,O43681 34 +Abnormal blood gas level 0.3467492905920418 0.0170399753204446 0.986404724700948 1.0 1.0 3 Q9Y3E5 1 +Dysuria 0.2962811606048255 0.0153521978360564 0.9877511995273623 1.0 1.0 7 O00170,P07741,Q8N5K1,O76024,P01889,Q8N0X7 6 +Ichthyosis 0.2683293448620832 0.0137796437315559 0.9890057829420515 1.0 1.0 30 Q15738,P48449,O95721,P04062,P18074,P51648,Q13642 7 +Abnormality of retinal pigmentation 0.251981249392852 0.0127661245743717 0.9898143829665916 1.0 1.0 57 O75306,Q9UG56,P18074,P00403,Q16836,P40939,Q15067,Q9BW83 8 +Abnormal iris pigmentation 0.2758793765245256 0.0123560803701027 0.9901415250946606 1.0 1.0 15 Q15056,Q9Y4P3,P35250 3 +Abnormal magnesium concentration 0.333741330069355 0.0123275176065418 0.9901643131471148 1.0 1.0 3 Q15813,Q9NP81 2 +Reduced systolic function 0.3333333333333276 0.0121968984138964 0.9902685243492132 1.0 1.0 3 P15924,P14923 2 +Male sexual dysfunction 0.2815621520247475 0.0121873406608689 0.9902761497660182 1.0 1.0 10 Q9BZH6,Q969G3,O43464 3 +Gaze evoked nystagmus 0.2817868837532344 0.0117588396529582 0.9906180195966694 1.0 1.0 9 P41440,Q9UBB4,Q10713 3 +Occipital meningocele 0.2975497369090955 0.0089226099434209 0.9928808817465596 1.0 1.0 4 P21964 1 +Anterior uveitis 0.3178294573643374 0.0079214636730282 0.9936796525362644 1.0 1.0 3 P01889,P14174 2 +Feeding difficulties in infancy 0.259409515376468 0.0075853193777246 0.9939478488169848 1.0 1.0 125 Q9Y619,Q9BUF5,Q9UHX1,O75306,O75648,P10253,P22695,Q99720,P23786,P35637,P18074,Q16836,P16219,O95831,P40939,Q9Y487,Q9UBM7,O43681 18 +Open bite 0.2746334243486966 0.0073434063425567 0.9941408621152236 1.0 1.0 14 P35250,Q15056,Q9Y4P3,P61978 4 +Pneumonia 0.262489471582204 0.0066163763477964 0.9947209339801092 1.0 1.0 44 Q13510,P04062,P16278 3 +Aplasia hypoplasia involving bones of the upper limbs 0.2491286398973989 0.0065228005958706 0.9947955950166256 1.0 1.0 108 Q9UHX1,O75844,Q03164,O95831,Q13510,Q9UBM7,Q14739 7 +Hypercalcemia 0.2741124925566084 0.00555915797001 0.995564456530858 1.0 1.0 15 Q15056,Q9Y4P3,P35250 3 +Babinski sign 0.2540101595704737 0.0048717578113572 0.9961129150343816 1.0 1.0 73 P41440,O95140,P35637,Q9NR77,O60701,Q6DKK2,P40939,O95831,Q15067,O43681,Q99720,P37198,Q8N0X7,Q13501 14 +Abnormal ventricular septum morphology 0.2502465103472744 0.0048390713197413 0.99613899477397 1.0 1.0 110 O75306,Q9UHX1,Q15056,Q8N183,P61978,P06280,O96028,P35250,P18074,Q14738,Q9Y4P3,Q9Y5S9,Q969G3,Q9UBM7,Q8WYQ5,P42892,Q14739 17 +Hypoventilation 0.278549044335368 0.0046763354937621 0.9962688377073112 1.0 1.0 10 O75306,Q8N183,P61978 3 +Chronic otitis media 0.2715249769469015 0.0045987107602317 0.9963307726177072 1.0 1.0 20 P21964,Q15056,O96028,Q13363,Q03519,P35250,Q9Y4P3,Q06787,P54819 9 +Small earlobe 0.289794634868279 0.0038673015149868 0.9969143475207384 1.0 1.0 4 P21964 1 +Prolonged neonatal jaundice 0.272693284341724 0.0026810372683594 0.9978608443193338 1.0 1.0 13 P61916,Q15904 2 +Acne 0.2767421761898899 0.0012113546228724 0.9990334790851284 1.0 1.0 11 Q9NZ08,Q92542,P21964 3 +Syringomyelia 0.2713178294573598 0.0011332999344398 0.999095757673115 1.0 1.0 3 Q9Y2U8,O60341 2 +Dermal atrophy 0.266000400475892 0.0001728219369065 0.9998621080454606 1.0 1.0 26 Q9NWM8,Q15392,O75844 3 diff --git a/msigdb_hp/selections.json b/msigdb_hp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..397593ea68b86cf78e489471e5bd0336878c11cd --- /dev/null +++ b/msigdb_hp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["11 pairs of ribs", "2 3 finger syndactyly", "2 3 toe cutaneous syndactyly", "2 3 toe syndactyly", "3 4 finger syndactyly", "3 methylglutaconic aciduria", "4 5 toe syndactyly", "Abdominal aortic aneurysm", "Abdominal distention", "Abdominal obesity", "Abdominal pain", "Abdominal wall muscle weakness", "Abducens palsy", "Abnormal 2nd finger morphology", "Abnormal 3rd finger morphology", "Abnormal 5th finger morphology", "Abnormal 5th finger phalanx morphology", "Abnormal abdomen morphology", "Abnormal acetabulum morphology", "Abnormal activity of mitochondrial respiratory chain", "Abnormal adipose tissue morphology", "Abnormal aggressive impulsive or violent behavior", "Abnormal aldolase level", "Abnormal anatomic location of the heart", "Abnormal anterior chamber morphology", "Abnormal anterior eye segment morphology", "Abnormal anterior horn cell morphology", "Abnormal aortic arch morphology", "Abnormal aortic morphology", "Abnormal aortic valve cusp morphology", "Abnormal aortic valve morphology", "Abnormal aortic valve physiology", "Abnormal arachnoid mater morphology", "Abnormal arm span", "Abnormal arterial physiology", "Abnormal astrocyte morphology", "Abnormal atrial arrangement", "Abnormal atrioventricular conduction", "Abnormal atrioventricular valve morphology", "Abnormal atrioventricular valve physiology", "Abnormal auditory evoked potentials", "Abnormal autonomic nervous system physiology", "Abnormal b cell morphology", "Abnormal b cell subset distribution", "Abnormal basal ganglia mri signal intensity", "Abnormal basophil count", "Abnormal basophil morphology", "Abnormal biliary tract morphology", "Abnormal bleeding", "Abnormal blistering of the skin", "Abnormal blood carbon dioxide level", "Abnormal blood chloride concentration", "Abnormal blood gas level", "Abnormal blood glucose concentration", "Abnormal blood inorganic cation concentration", "Abnormal blood ion concentration", "Abnormal blood monovalent inorganic cation concentration", "Abnormal blood phosphate concentration", "Abnormal blood potassium concentration", "Abnormal blood sodium concentration", "Abnormal blood transition element cation concentration", "Abnormal blood zinc concentration", "Abnormal bone structure", "Abnormal brain choline level by mrs", "Abnormal brain lactate level by mrs", "Abnormal brain n acetyl aspartate level by mrs", "Abnormal brain positron emission tomography", "Abnormal brainstem morphology", "Abnormal brainstem mri signal intensity", "Abnormal branching pattern of the aortic arch", "Abnormal breath sound", "Abnormal bronchoalveolar lavage fluid morphology", "Abnormal bronchus morphology", "Abnormal bronchus physiology", "Abnormal c peptide level", "Abnormal c reactive protein level", "Abnormal calcium phosphate regulating hormone level", "Abnormal cardiac atrium morphology", "Abnormal cardiac septum morphology", "Abnormal cardiac test", "Abnormal cardiac ventricle morphology", "Abnormal cardiac ventricular function", "Abnormal cardiomyocyte morphology", "Abnormal carotid artery morphology", "Abnormal cartilage morphology", "Abnormal caudate nucleus morphology", "Abnormal cd4 cd8 ratio", "Abnormal cell morphology", "Abnormal cell proliferation", "Abnormal cellular composition of bronchoalveolar fluid", "Abnormal cellular phenotype", "Abnormal central sensory function", "Abnormal cerebellar vermis morphology", "Abnormal cerebral artery morphology", "Abnormal cerebral cortex morphology", "Abnormal cerebral vascular morphology", "Abnormal cerebral vein morphology", "Abnormal cerebral ventricle morphology", "Abnormal cerebrospinal fluid metabolite concentration", "Abnormal cervical curvature", "Abnormal cervical spine morphology", "Abnormal chorioretinal morphology", "Abnormal choroid morphology", "Abnormal choroid plexus morphology", "Abnormal chromosome morphology", "Abnormal ciliary body morphology", "Abnormal circulating acetylcarnitine concentration", "Abnormal circulating albumin concentration", "Abnormal circulating amino acid concentration", "Abnormal circulating amylase level", "Abnormal circulating androgen level", "Abnormal circulating apolipoprotein concentration", "Abnormal circulating arginine concentration", "Abnormal circulating aromatic amino acid concentration", "Abnormal circulating aspartate family amino acid concentration", "Abnormal circulating bilirubin concentration", "Abnormal circulating branched chain amino acid concentration", "Abnormal circulating carbohydrate concentration", "Abnormal circulating carboxylic acid concentration", "Abnormal circulating ceruloplasmin concentration", "Abnormal circulating cholesterol concentration", "Abnormal circulating citrulline concentration", "Abnormal circulating copper concentration", "Abnormal circulating creatinine concentration", "Abnormal circulating dehydroepiandrosterone concentration", "Abnormal circulating dicarboxylic acid concentration", "Abnormal circulating estrogen level", "Abnormal circulating fatty acid anion concentration", "Abnormal circulating fatty acid concentration", "Abnormal circulating ferritin concentration", "Abnormal circulating follicle stimulating hormone concentration", "Abnormal circulating free fatty acid concentration", "Abnormal circulating gaba concentration", "Abnormal circulating glutamine concentration", "Abnormal circulating glutamine family amino acid concentration", "Abnormal circulating glycine concentration", "Abnormal circulating gonadotropin concentration", "Abnormal circulating hormone concentration", "Abnormal circulating iga level", "Abnormal circulating ige level", "Abnormal circulating igg level", "Abnormal circulating igm level", "Abnormal circulating inhibin level", "Abnormal circulating lipid concentration", "Abnormal circulating long chain fatty acid concentration", "Abnormal circulating metabolite concentration", "Abnormal circulating methionine concentration", "Abnormal circulating monocarboxylic acid cocentration", "Abnormal circulating nitrogen compound concentration", "Abnormal circulating non proteinogenic amino acid concentration", "Abnormal circulating nucleobase concentration", "Abnormal circulating phenylalanine concentration", "Abnormal circulating porphyrin concentration", "Abnormal circulating progesterone level", "Abnormal circulating proline concentration", "Abnormal circulating protein concentration", "Abnormal circulating proteinogenic amino acid concentration", "Abnormal circulating proteinogenic amino acid derivative concentration", "Abnormal circulating pyruvate family amino acid concentration", "Abnormal circulating renin", "Abnormal circulating serine concentration", "Abnormal circulating serine family amino acid concentration", "Abnormal circulating sex hormone concentration", "Abnormal circulating sulfur amino acid concentration", "Abnormal circulating tyrosine concentration", "Abnormal clavicle morphology", "Abnormal cns myelination", "Abnormal cochlea morphology", "Abnormal conjugate eye movement", "Abnormal conjunctiva morphology", "Abnormal connection of the cardiac segments", "Abnormal consumption behavior", "Abnormal conus terminalis morphology", "Abnormal cornea morphology", "Abnormal corneal endothelium morphology", "Abnormal corneal epithelium morphology", "Abnormal coronary artery morphology", "Abnormal corpus callosum morphology", "Abnormal corpus striatum morphology", "Abnormal cortical bone morphology", "Abnormal cortical gyration", "Abnormal cranial nerve morphology", "Abnormal cranial nerve physiology", "Abnormal cry", "Abnormal csf carboxylic acid concentration", "Abnormal csf metabolite level", "Abnormal csf protein level", "Abnormal csf pyruvate family amino acid concentration", "Abnormal cutaneous elastic fiber morphology", "Abnormal delayed hypersensitivity skin test", "Abnormal delivery", "Abnormal dense granules", "Abnormal dental pulp morphology", "Abnormal dental root morphology", "Abnormal dentate nucleus morphology", "Abnormal dentin morphology", "Abnormal dermatoglyphics", "Abnormal dermoepidermal junction morphology", "Abnormal descemet membrane morphology", "Abnormal diaphysis morphology", "Abnormal distal phalanx morphology of finger", "Abnormal dlco", "Abnormal drinking behavior", "Abnormal duodenum morphology", "Abnormal dura mater morphology", "Abnormal eating behavior", "Abnormal echocardiogram", "Abnormal elasticity of skin", "Abnormal electrophysiology of sinoatrial node origin", "Abnormal electroretinogram", "Abnormal emotion affect behavior", "Abnormal enchondral ossification", "Abnormal endocardium morphology", "Abnormal endocrine physiology", "Abnormal enzyme coenzyme activity", "Abnormal eosinophil morphology", "Abnormal epidermal morphology", "Abnormal epiglottis morphology", "Abnormal epiphyseal ossification", "Abnormal epiphysis morphology of the phalanges of the hand", "Abnormal erythrocyte enzyme level", "Abnormal erythrocyte morphology", "Abnormal erythrocyte physiology", "Abnormal erythrocyte sedimentation rate", "Abnormal esophagus morphology", "Abnormal esophagus physiology", "Abnormal external genitalia", "Abnormal exteroceptive sensation", "Abnormal eyebrow morphology", "Abnormal eyelash morphology", "Abnormal eyelid morphology", "Abnormal eyelid physiology", "Abnormal facial expression", "Abnormal facial shape", "Abnormal factor ix activity", "Abnormal fallopian tube morphology", "Abnormal fear anxiety related behavior", "Abnormal female reproductive system physiology", "Abnormal femoral head morphology", "Abnormal femoral neck head morphology", "Abnormal femoral neck morphology", "Abnormal finger phalanx morphology", "Abnormal fingernail morphology", "Abnormal fingertip morphology", "Abnormal foot bone ossification", "Abnormal foramen magnum morphology", "Abnormal forearm bone morphology", "Abnormal form of the vertebral bodies", "Abnormal foveal morphology", "Abnormal full field electroretinogram", "Abnormal fundus autofluorescence imaging", "Abnormal gallbladder morphology", "Abnormal gastrointestinal motility", "Abnormal glial cell morphology", "Abnormal globus pallidus morphology", "Abnormal glomerular basement membrane morphology", "Abnormal glomerular filtration rate", "Abnormal glomerular mesangial cellularity", "Abnormal glomerular mesangium morphology", "Abnormal glucose homeostasis", "Abnormal glycosylation", "Abnormal granulocyte count", "Abnormal granulocytopoietic cell morphology", "Abnormal greater sciatic notch morphology", "Abnormal growth hormone level", "Abnormal hair laboratory examination", "Abnormal hair morphology", "Abnormal hair pattern", "Abnormal hair quantity", "Abnormal hair whorl", "Abnormal hand bone ossification", "Abnormal hand morphology", "Abnormal hdl cholesterol concentration", "Abnormal head movements", "Abnormal heart rate variability", "Abnormal heart sound", "Abnormal heart valve morphology", "Abnormal heart valve physiology", "Abnormal hemoglobin", "Abnormal hemoglobin concentration", "Abnormal hepatic iron concentration", "Abnormal humerus morphology", "Abnormal hypothalamus morphology", "Abnormal hypothalamus physiology", "Abnormal ileum morphology", "Abnormal iliac wing morphology", "Abnormal ilium morphology", "Abnormal immune system morphology", "Abnormal incisor morphology", "Abnormal inflammatory response", "Abnormal insulin level", "Abnormal internal genitalia", "Abnormal intestine morphology", "Abnormal intraocular pressure", "Abnormal involuntary eye movements", "Abnormal iris pigmentation", "Abnormal jaw morphology", "Abnormal joint morphology", "Abnormal labia majora morphology", "Abnormal labia minora morphology", "Abnormal labia morphology", "Abnormal lacrimal duct morphology", "Abnormal lacrimal gland morphology", "Abnormal lactate dehydrogenase level", "Abnormal large intestine morphology", "Abnormal large intestine physiology", "Abnormal larynx morphology", "Abnormal larynx physiology", "Abnormal lateral ventricle morphology", "Abnormal ldl cholesterol concentration", "Abnormal left atrium morphology", "Abnormal left ventricle morphology", "Abnormal left ventricular outflow tract morphology", "Abnormal length of corpus callosum", "Abnormal leukocyte count", "Abnormal leukocyte physiology", "Abnormal levels of alpha fetoprotein", "Abnormal libido", "Abnormal light and dark adapted electroretinogram", "Abnormal lip morphology", "Abnormal liver morphology", "Abnormal liver parenchyma morphology", "Abnormal liver physiology", "Abnormal localization of kidney", "Abnormal location of ears", "Abnormal lower limb bone morphology", "Abnormal lower motor neuron morphology", "Abnormal lumbar spine morphology", "Abnormal lung development", "Abnormal lung lobation", "Abnormal lymphatic vessel morphology", "Abnormal lymphocyte morphology", "Abnormal macrophage morphology", "Abnormal macroscopic urine appearance", "Abnormal macular morphology", "Abnormal magnesium concentration", "Abnormal male reproductive system physiology", "Abnormal mandibular ramus morphology", "Abnormal mast cell morphology", "Abnormal mean corpuscular hemoglobin concentration", "Abnormal mean corpuscular volume", "Abnormal megakaryocyte morphology", "Abnormal meningeal morphology", "Abnormal metabolic brain imaging by mrs", "Abnormal metabolism", "Abnormal metacarpal morphology", "Abnormal metaphyseal trabeculation", "Abnormal metatarsal morphology", "Abnormal midbrain morphology", "Abnormal middle phalanx morphology of the hand", "Abnormal mitochondria in muscle tissue", "Abnormal mitochondrial morphology", "Abnormal mitochondrial shape", "Abnormal mitral valve physiology", "Abnormal monocyte morphology", "Abnormal morphology of myocardial trabeculae", "Abnormal morphology of the abdominal musculature", "Abnormal morphology of the choroidal vasculature", "Abnormal morphology of the conjunctival vasculature", "Abnormal morphology of the great vessels", "Abnormal morphology of the limbic system", "Abnormal morphology of the musculature of the neck", "Abnormal morphology of the olfactory bulb", "Abnormal morphology of the radius", "Abnormal motor evoked potentials", "Abnormal motor nerve conduction velocity", "Abnormal muscle fiber morphology", "Abnormal muscle fiber protein expression", "Abnormal muscle fiber type distribution", "Abnormal muscle glycogen content", "Abnormal myelination", "Abnormal myeloid cell morphology", "Abnormal myeloid leukocyte morphology", "Abnormal myocardium morphology", "Abnormal nasal base", "Abnormal nasal bridge morphology", "Abnormal nasal mucosa morphology", "Abnormal nasolacrimal system morphology", "Abnormal natural killer cell morphology", "Abnormal natural killer cell physiology", "Abnormal nephron morphology", "Abnormal nerve conduction velocity", "Abnormal nervous system electrophysiology", "Abnormal neural tube morphology", "Abnormal neuron morphology", "Abnormal neutrophil count", "Abnormal nipple morphology", "Abnormal number of erythroid precursors", "Abnormal number of granulocyte precursors", "Abnormal number of incisors", "Abnormal number of teeth", "Abnormal odontoid tissue morphology", "Abnormal optical coherence tomography", "Abnormal oral frenulum morphology", "Abnormal oral glucose tolerance", "Abnormal oral mucosa morphology", "Abnormal oral physiology", "Abnormal ossification involving the femoral head and neck", "Abnormal ovarian morphology", "Abnormal ovarian physiology", "Abnormal palate morphology", "Abnormal palmar dermatoglyphics", "Abnormal pancreas morphology", "Abnormal pancreas size", "Abnormal paranasal sinus morphology", "Abnormal parietal bone morphology", "Abnormal parotid gland morphology", "Abnormal patella morphology", "Abnormal pattern of respiration", "Abnormal pelvis bone morphology", "Abnormal pelvis bone ossification", "Abnormal penis morphology", "Abnormal pericardium morphology", "Abnormal peripheral action potential amplitude", "Abnormal peripheral myelination", "Abnormal peripheral nervous system morphology", "Abnormal peripheral nervous system physiology", "Abnormal peristalsis", "Abnormal periventricular white matter morphology", "Abnormal phalangeal joint morphology of the hand", "Abnormal pharynx morphology", "Abnormal pigmentation of the oral mucosa", "Abnormal pineal morphology", "Abnormal placenta morphology", "Abnormal placental membrane morphology", "Abnormal placental size", "Abnormal platelet aggregation", "Abnormal platelet function", "Abnormal platelet granules", "Abnormal platelet morphology", "Abnormal platelet volume", "Abnormal pleura morphology", "Abnormal pons morphology", "Abnormal posterior segment imaging", "Abnormal pr interval", "Abnormal preputium morphology", "Abnormal prolactin level", "Abnormal proportion of cd4 positive t cells", "Abnormal proportion of cd8 positive t cells", "Abnormal proportion of class switched memory b cells", "Abnormal proportion of double negative alpha beta regulatory t cell", "Abnormal prostate morphology", "Abnormal protein glycosylation", "Abnormal protein o linked glycosylation", "Abnormal proximal phalanx morphology of the hand", "Abnormal pulmonary interstitial morphology", "Abnormal pulmonary thoracic imaging finding", "Abnormal pulmonary valve morphology", "Abnormal pulmonary valve physiology", "Abnormal pupil morphology", "Abnormal pupillary function", "Abnormal pupillary light reflex", "Abnormal pyramidal sign", "Abnormal qrs complex", "Abnormal qt interval", "Abnormal rectum morphology", "Abnormal reflex", "Abnormal renal collecting system morphology", "Abnormal renal cortex morphology", "Abnormal renal corticomedullary differentiation", "Abnormal renal echogenicity", "Abnormal renal insterstitial morphology", "Abnormal renal medulla morphology", "Abnormal renal morphology", "Abnormal renal pelvis morphology", "Abnormal renal physiology", "Abnormal renal resorption", "Abnormal renal tubule morphology", "Abnormal renal vascular morphology", "Abnormal respiratory motile cilium morphology", "Abnormal respiratory motile cilium physiology", "Abnormal respiratory system morphology", "Abnormal response to acth stimulation test", "Abnormal response to endocrine stimulation test", "Abnormal response to insulin tolerance test", "Abnormal reticulocyte morphology", "Abnormal retinal artery morphology", "Abnormal retinal morphology", "Abnormal retinal vascular morphology", "Abnormal rib cage morphology", "Abnormal rib ossification", "Abnormal right atrium morphology", "Abnormal right ventricle morphology", "Abnormal saccadic eye movements", "Abnormal sacroiliac joint morphology", "Abnormal sacrum morphology", "Abnormal salivary gland morphology", "Abnormal sarcomere morphology", "Abnormal scalp morphology", "Abnormal scapula morphology", "Abnormal sclera morphology", "Abnormal scrotal rugation", "Abnormal sella turcica morphology", "Abnormal sensory nerve conduction velocity", "Abnormal serum insulin like growth factor 1 level", "Abnormal serum interferon level", "Abnormal serum interleukin level", "Abnormal serum iron concentration", "Abnormal sex determination", "Abnormal shape of the frontal region", "Abnormal shape of the occiput", "Abnormal shape of the palpebral fissure", "Abnormal sharpey fiber morphology", "Abnormal shoulder morphology", "Abnormal shoulder physiology", "Abnormal size of pituitary gland", "Abnormal size of the clitoris", "Abnormal size of the palpebral fissures", "Abnormal skin morphology of the palm", "Abnormal social behavior", "Abnormal soft palate morphology", "Abnormal speech prosody", "Abnormal sperm motility", "Abnormal spermatogenesis", "Abnormal spinal meningeal morphology", "Abnormal sputum", "Abnormal sternal ossification", "Abnormal sternum morphology", "Abnormal stomach morphology", "Abnormal stool composition", "Abnormal subarachnoid space morphology", "Abnormal subclavian artery morphology", "Abnormal subcutaneous fat tissue distribution", "Abnormal substantia nigra morphology", "Abnormal superior cerebellar peduncle morphology", "Abnormal sweat gland morphology", "Abnormal synaptic transmission at the neuromuscular junction", "Abnormal systemic arterial morphology", "Abnormal systemic blood pressure", "Abnormal t cell activation", "Abnormal t cell morphology", "Abnormal t cell proliferation", "Abnormal t cell subset distribution", "Abnormal t wave", "Abnormal talus morphology", "Abnormal temper tantrums", "Abnormal temporal bone morphology", "Abnormal tendon morphology", "Abnormal testis morphology", "Abnormal thalamic mri signal intensity", "Abnormal thalamic size", "Abnormal thoracic spine morphology", "Abnormal thorax morphology", "Abnormal thrombocyte morphology", "Abnormal thrombosis", "Abnormal thumb morphology", "Abnormal thyroid hormone level", "Abnormal thyroid morphology", "Abnormal thyroid stimulating hormone level", "Abnormal tissue metabolite concentration", "Abnormal toenail morphology", "Abnormal tongue morphology", "Abnormal tongue physiology", "Abnormal trabecular bone morphology", "Abnormal tracheal morphology", "Abnormal tracheobronchial morphology", "Abnormal transferrin saturation", "Abnormal tricuspid valve morphology", "Abnormal tricuspid valve physiology", "Abnormal umbilicus morphology", "Abnormal upper limb bone morphology", "Abnormal upper motor neuron morphology", "Abnormal ureter morphology", "Abnormal ureter physiology", "Abnormal urinary color", "Abnormal urinary electrolyte concentration", "Abnormal urine alpha ketoglutarate concentration", "Abnormal urine carbohydrate level", "Abnormal urine carboxylic acid level", "Abnormal urine cytology", "Abnormal urine hormone level", "Abnormal urine magnesium concentration", "Abnormal urine metabolite level", "Abnormal urine ph", "Abnormal urine phosphate concentration", "Abnormal urine potassium concentration", "Abnormal urine protein level", "Abnormal urine sodium concentration", "Abnormal uterus morphology", "Abnormal uvea morphology", "Abnormal uvula morphology", "Abnormal vagina morphology", "Abnormal vascular morphology", "Abnormal vascular physiology", "Abnormal vena cava morphology", "Abnormal venous morphology", "Abnormal ventricular septum morphology", "Abnormal vertebral morphology", "Abnormal vertebral segmentation and fusion", "Abnormal vestibulo ocular reflex", "Abnormal visual electrophysiology", "Abnormal visual field test", "Abnormal visual fixation", "Abnormal vitamin b12 level", "Abnormal vitreous humor morphology", "Abnormal waist to hip ratio", "Abnormal z disc morphology", "Abnormalities of placenta or umbilical cord", "Abnormality iris morphology", "Abnormality of abdominal situs", "Abnormality of acid base homeostasis", "Abnormality of adrenal morphology", "Abnormality of adrenal physiology", "Abnormality of alkaline phosphatase level", "Abnormality of amino acid metabolism", "Abnormality of bladder morphology", "Abnormality of blood circulation", "Abnormality of blood volume homeostasis", "Abnormality of body mass index", "Abnormality of bone marrow cell morphology", "Abnormality of bone mineral density", "Abnormality of canine", "Abnormality of cardiovascular system electrophysiology", "Abnormality of carpal bone ossification", "Abnormality of cartilage of external ear", "Abnormality of central nervous system electrophysiology", "Abnormality of chorioretinal pigmentation", "Abnormality of chromosome segregation", "Abnormality of chromosome stability", "Abnormality of circulating adrenocorticotropin level", "Abnormality of circulating enzyme level", "Abnormality of circulating fibrinogen", "Abnormality of circulating glucocorticoid level", "Abnormality of circulating leptin level", "Abnormality of coagulation", "Abnormality of complement system", "Abnormality of coordination", "Abnormality of corneal size", "Abnormality of corneal stroma", "Abnormality of corneal thickness", "Abnormality of cranial sutures", "Abnormality of dental color", "Abnormality of dental eruption", "Abnormality of dental morphology", "Abnormality of dental structure", "Abnormality of dermal melanosomes", "Abnormality of digestive system morphology", "Abnormality of dna repair", "Abnormality of earlobe", "Abnormality of endocrine pancreas physiology", "Abnormality of epiphysis morphology", "Abnormality of exocrine pancreas physiology", "Abnormality of extrapyramidal motor function", "Abnormality of facial adipose tissue", "Abnormality of facial musculature", "Abnormality of facial skeleton", "Abnormality of facial soft tissue", "Abnormality of female external genitalia", "Abnormality of femur morphology", "Abnormality of fibula morphology", "Abnormality of finger", "Abnormality of fluid regulation", "Abnormality of folate metabolism", "Abnormality of fontanelles", "Abnormality of foveal pigmentation", "Abnormality of frontal sinus", "Abnormality of fundus pigmentation", "Abnormality of globe location", "Abnormality of globe size", "Abnormality of glycolipid metabolism", "Abnormality of hair growth", "Abnormality of hair pigmentation", "Abnormality of hair texture", "Abnormality of hand joint mobility", "Abnormality of head blood vessel", "Abnormality of hepatobiliary system physiology", "Abnormality of hindbrain morphology", "Abnormality of humoral immunity", "Abnormality of immune serum protein physiology", "Abnormality of iron homeostasis", "Abnormality of krebs cycle metabolism", "Abnormality of limb epiphysis morphology", "Abnormality of lipoprotein cholesterol concentration", "Abnormality of long bone morphology", "Abnormality of lower limb epiphysis morphology", "Abnormality of lower limb joint", "Abnormality of lower limb metaphyses", "Abnormality of lower lip", "Abnormality of lysosomal metabolism", "Abnormality of macular pigmentation", "Abnormality of malar bones", "Abnormality of male internal genitalia", "Abnormality of metacarpal epiphyses", "Abnormality of metacarpophalangeal joint", "Abnormality of mouth shape", "Abnormality of mouth size", "Abnormality of muscle size", "Abnormality of nail color", "Abnormality of neuronal migration", "Abnormality of neutrophil morphology", "Abnormality of neutrophil physiology", "Abnormality of neutrophils", "Abnormality of ocular smooth pursuit", "Abnormality of pain sensation", "Abnormality of pancreas physiology", "Abnormality of pelvic girdle bone morphology", "Abnormality of periauricular region", "Abnormality of peripheral nerves", "Abnormality of prenatal development or birth", "Abnormality of primary teeth", "Abnormality of prothrombin", "Abnormality of pulmonary circulation", "Abnormality of refraction", "Abnormality of renal excretion", "Abnormality of renin angiotensin system", "Abnormality of reproductive system physiology", "Abnormality of retinal pigmentation", "Abnormality of salivation", "Abnormality of secondary sexual hair", "Abnormality of skeletal maturation", "Abnormality of skeletal muscle fiber size", "Abnormality of skin adnexa physiology", "Abnormality of skin physiology", "Abnormality of skin pigmentation", "Abnormality of skull ossification", "Abnormality of small intestinal villus morphology", "Abnormality of somatosensory evoked potentials", "Abnormality of subcutaneous fat tissue", "Abnormality of t cell physiology", "Abnormality of taste sensation", "Abnormality of temperature regulation", "Abnormality of thalamus morphology", "Abnormality of the 1st metacarpal", "Abnormality of the 2nd toe", "Abnormality of the 3rd toe", "Abnormality of the 4th metacarpal", "Abnormality of the 5th metacarpal", "Abnormality of the 5th toe", "Abnormality of the abdominal organs", "Abnormality of the abdominal wall", "Abnormality of the achilles tendon", "Abnormality of the adrenal glands", "Abnormality of the alveolar ridges", "Abnormality of the amniotic fluid", "Abnormality of the ankles", "Abnormality of the anterior fontanelle", "Abnormality of the antihelix", "Abnormality of the antitragus", "Abnormality of the anus", "Abnormality of the auditory canal", "Abnormality of the autonomic nervous system", "Abnormality of the axillary hair", "Abnormality of the basal ganglia", "Abnormality of the biliary system", "Abnormality of the bladder", "Abnormality of the brainstem white matter", "Abnormality of the breast", "Abnormality of the calcaneus", "Abnormality of the calf", "Abnormality of the calf musculature", "Abnormality of the calvaria", "Abnormality of the carpal bones", "Abnormality of the cerebral subcortex", "Abnormality of the cerebrospinal fluid", "Abnormality of the cervical spine", "Abnormality of the cheek", "Abnormality of the chin", "Abnormality of the choanae", "Abnormality of the clitoris", "Abnormality of the coagulation cascade", "Abnormality of the columella", "Abnormality of the common coagulation pathway", "Abnormality of the costochondral junction", "Abnormality of the crus of the helix", "Abnormality of the curvature of the cornea", "Abnormality of the curvature of the vertebral column", "Abnormality of the dentition", "Abnormality of the diaphragm", "Abnormality of the diencephalon", "Abnormality of the distal phalanges of the toes", "Abnormality of the distal phalanx of the thumb", "Abnormality of the dorsal column of the spinal cord", "Abnormality of the elbow", "Abnormality of the endometrium", "Abnormality of the epididymis", "Abnormality of the epiphyses of the distal phalanx of finger", "Abnormality of the external nose", "Abnormality of the extraocular muscles", "Abnormality of the extrinsic pathway", "Abnormality of the female genitalia", "Abnormality of the fetal cardiovascular system", "Abnormality of the fifth metatarsal bone", "Abnormality of the fontanelles or cranial sutures", "Abnormality of the foot musculature", "Abnormality of the forearm", "Abnormality of the forehead", "Abnormality of the frontal hairline", "Abnormality of the gallbladder", "Abnormality of the gastric mucosa", "Abnormality of the gingiva", "Abnormality of the glabella", "Abnormality of the glenoid fossa", "Abnormality of the hairline", "Abnormality of the hallux", "Abnormality of the helix", "Abnormality of the hepatic vasculature", "Abnormality of the humeroradial joint", "Abnormality of the humerus", "Abnormality of the hypothalamus pituitary axis", "Abnormality of the hypothenar eminence", "Abnormality of the incisor", "Abnormality of the inner ear", "Abnormality of the internal auditory canal", "Abnormality of the intervertebral disk", "Abnormality of the intrahepatic bile duct", "Abnormality of the intrinsic pathway", "Abnormality of the kidney", "Abnormality of the knee", "Abnormality of the larynx", "Abnormality of the lens", "Abnormality of the leydig cells", "Abnormality of the liver", "Abnormality of the lower urinary tract", "Abnormality of the lymph nodes", "Abnormality of the lymphatic system", "Abnormality of the mastoid", "Abnormality of the maxilla", "Abnormality of the menstrual cycle", "Abnormality of the metacarpal bones", "Abnormality of the metaphysis", "Abnormality of the metopic suture", "Abnormality of the middle ear", "Abnormality of the middle ear ossicles", "Abnormality of the middle phalanx of the 5th finger", "Abnormality of the midface", "Abnormality of the mitochondrion", "Abnormality of the musculature of the hand", "Abnormality of the musculature of the limbs", "Abnormality of the musculature of the lower limbs", "Abnormality of the musculature of the thigh", "Abnormality of the musculature of the upper arm", "Abnormality of the musculature of the upper limbs", "Abnormality of the nail", "Abnormality of the nasal alae", "Abnormality of the nasal bone", "Abnormality of the nasal cavity", "Abnormality of the nasal dorsum", "Abnormality of the nasal septum", "Abnormality of the nasal skeleton", "Abnormality of the nasal tip", "Abnormality of the nasolabial region", "Abnormality of the neck", "Abnormality of the odontoid process", "Abnormality of the optic nerve", "Abnormality of the outer ear", "Abnormality of the ovary", "Abnormality of the palm", "Abnormality of the palpebral fissures", "Abnormality of the pancreas", "Abnormality of the parathyroid gland", "Abnormality of the parathyroid morphology", "Abnormality of the periorbital region", "Abnormality of the peripheral nervous system", "Abnormality of the peritoneum", "Abnormality of the periungual region", "Abnormality of the phalanges of the toes", "Abnormality of the pharynx", "Abnormality of the philtrum", "Abnormality of the pineal gland", "Abnormality of the pinna", "Abnormality of the pituitary gland", "Abnormality of the plantar skin of foot", "Abnormality of the posterior pituitary", "Abnormality of the protein c anticoagulant pathway", "Abnormality of the proximal phalanx of the thumb", "Abnormality of the pubic bone", "Abnormality of the pubic hair", "Abnormality of the pulmonary artery", "Abnormality of the pulmonary vasculature", "Abnormality of the pulmonary veins", "Abnormality of the pylorus", "Abnormality of the radial head", "Abnormality of the radioulnar joints", "Abnormality of the ribs", "Abnormality of the scrotum", "Abnormality of the sense of smell", "Abnormality of the septum pellucidum", "Abnormality of the shoulder girdle musculature", "Abnormality of the skull base", "Abnormality of the small intestine", "Abnormality of the spinal cord", "Abnormality of the spleen", "Abnormality of the stapes", "Abnormality of the subungual region", "Abnormality of the supraorbital ridges", "Abnormality of the synovia", "Abnormality of the tarsal bones", "Abnormality of the temporomandibular joint", "Abnormality of the testis size", "Abnormality of the thenar eminence", "Abnormality of the thoracic cavity", "Abnormality of the thymus", "Abnormality of the thyroid gland", "Abnormality of the tongue", "Abnormality of the tonsils", "Abnormality of the tragus", "Abnormality of the ulna", "Abnormality of the umbilical cord", "Abnormality of the upper arm", "Abnormality of the upper respiratory tract", "Abnormality of the ureter", "Abnormality of the urethra", "Abnormality of the urinary system physiology", "Abnormality of the uterus", "Abnormality of the vasculature of the eye", "Abnormality of the vertebral endplates", "Abnormality of the vestibulocochlear nerve", "Abnormality of the voice", "Abnormality of the wrist", "Abnormality of the zygomatic bone", "Abnormality of thyroid physiology", "Abnormality of tibia morphology", "Abnormality of toe", "Abnormality of ulnar metaphysis", "Abnormality of upper limb epiphysis morphology", "Abnormality of upper limb joint", "Abnormality of upper limb metaphysis", "Abnormality of upper lip", "Abnormality of upper lip vermillion", "Abnormality of urinary uric acid concentration", "Abnormality of urine calcium concentration", "Abnormality of urine catecholamine concentration", "Abnormality of urine homeostasis", "Abnormality of visual evoked potentials", "Abnormality of vitamin a metabolism", "Abnormality of vitamin b metabolism", "Abnormality of vitamin b12 metabolism", "Abnormality of vitamin d metabolism", "Abnormality of vitamin e metabolism", "Abnormality of vitamin k metabolism", "Abnormality of vitamin metabolism", "Abnormality on pulmonary function testing", "Abnormally folded helix", "Abnormally large globe", "Abnormally lax or hyperextensible skin", "Abnormally low pitched voice", "Abnormally ossified vertebrae", "Abnormally shaped carpal bones", "Abscess", "Absence of pubertal development", "Absence of secondary sex characteristics", "Absence of subcutaneous fat", "Absent axillary hair", "Absent brainstem auditory responses", "Absent distal phalanges", "Absent earlobe", "Absent epiphyses", "Absent eyebrow", "Absent facial hair", "Absent fingernail", "Absent forearm bone", "Absent foveal reflex", "Absent frontal sinuses", "Absent hair", "Absent hypoplastic paranasal sinuses", "Absent nares", "Absent nipple", "Absent or minimally ossified vertebral bodies", "Absent outer dynein arms", "Absent palmar crease", "Absent septum pellucidum", "Absent shortened dynein arms", "Absent speech", "Absent sternal ossification", "Absent testis", "Absent thumb", "Absent thumbnail", "Absent toe", "Absent toenail", "Acanthocytosis", "Acantholysis", "Acanthosis nigricans", "Accelerated atherosclerosis", "Accelerated skeletal maturation", "Accessory oral frenulum", "Accessory spleen", "Acetabular dysplasia", "Achilles tendon contracture", "Acidemia", "Acne", "Acne inversa", "Acquired abnormal hair pattern", "Acral blistering", "Acral ulceration", "Acromesomelia", "Acromicria", "Acroparesthesia", "Action tremor", "Acute coronary syndrome", "Acute encephalopathy", "Acute hepatic failure", "Acute kidney injury", "Acute leukemia", "Acute lymphoblastic leukemia", "Acute myeloid leukemia", "Acute pancreatitis", "Acute phase response", "Addictive behavior", "Adducted thumb", "Adenocarcinoma of the colon", "Adenocarcinoma of the intestines", "Adenocarcinoma of the small intestine", "Adenoma sebaceum", "Adenomatous colonic polyposis", "Adipose tissue loss", "Adrenal hyperplasia", "Adrenal hypoplasia", "Adrenal insufficiency", "Adrenal overactivity", "Adrenocortical abnormality", "Adrenocortical carcinoma", "Adrenocorticotropic hormone deficiency", "Adrenocorticotropic hormone excess", "Adrenocorticotropin deficient adrenal insufficiency", "Adult onset", "Adult onset sensorineural hearing impairment", "Advanced eruption of teeth", "Agammaglobulinemia", "Aganglionic megacolon", "Agenesis of central incisor", "Agenesis of cerebellar vermis", "Agenesis of corpus callosum", "Agenesis of incisor", "Agenesis of lateral incisor", "Agenesis of maxillary incisor", "Aggressive behavior", "Agitation", "Agnosia", "Agyria", "Airway obstruction", "Akinesia", "Alacrima", "Albinism", "Albuminuria", "Alexia", "Alkalosis", "Allergic rhinitis", "Allergy", "Alopecia", "Alopecia of scalp", "Alopecia totalis", "Alopecia universalis", "Alternating esotropia", "Alveolar rhabdomyosarcoma", "Alveolar ridge overgrowth", "Alzheimer disease", "Amaurosis fugax", "Ambiguous genitalia", "Ambiguous genitalia female", "Ambiguous genitalia male", "Amblyopia", "Amegakaryocytic thrombocytopenia", "Amelogenesis imperfecta", "Amenorrhea", "Aminoaciduria", "Amniotic constriction ring", "Amyloidosis", "Amyotrophic lateral sclerosis", "Anal atresia", "Anal fissure", "Anal stenosis", "Anaphylactic shock", "Anarthria", "Anasarca", "Anemia of inadequate production", "Anencephaly", "Angina pectoris", "Angioedema", "Angiofibromas", "Angioid streaks of the fundus", "Angiokeratoma", "Angular cheilitis", "Anhidrosis", "Aniridia", "Anisocoria", "Anisocytosis", "Anisopoikilocytosis", "Anisospondyly", "Ankle clonus", "Ankle flexion contracture", "Ankle weakness", "Ankyloblepharon", "Ankyloglossia", "Ankylosis", "Annular pancreas", "Anodontia", "Anomalous trichromacy", "Anonychia", "Anophthalmia", "Anorectal anomaly", "Anorexia", "Anosmia", "Anotia", "Antenatal onset", "Anterior chamber synechiae", "Anterior open bite malocclusion", "Anterior pituitary dysgenesis", "Anterior plagiocephaly", "Anterior rib cupping", "Anterior synechiae of the anterior chamber", "Anterior uveitis", "Anteriorly placed anus", "Anteverted ears", "Anti thyroid peroxidase antibody positivity", "Antineutrophil antibody positivity", "Antinuclear antibody positivity", "Antiphospholipid antibody positivity", "Aortic aneurysm", "Aortic arch aneurysm", "Aortic atherosclerotic lesion", "Aortic dissection", "Aortic regurgitation", "Aortic root aneurysm", "Aortic valve calcification", "Aortic valve stenosis", "Aphasia", "Aphthous ulcer", "Aplasia cutis congenita", "Aplasia cutis congenita of scalp", "Aplasia cutis congenita on trunk or limbs", "Aplasia cutis congenita over the scalp vertex", "Aplasia hypoplasia affecting bones of the axial skeleton", "Aplasia hypoplasia affecting the anterior segment of the eye", "Aplasia hypoplasia affecting the eye", "Aplasia hypoplasia affecting the fundus", "Aplasia hypoplasia involving bones of the feet", "Aplasia hypoplasia involving bones of the lower limbs", "Aplasia hypoplasia involving bones of the thorax", "Aplasia hypoplasia involving bones of the upper limbs", "Aplasia hypoplasia involving forearm bones", "Aplasia hypoplasia involving the carpal bones", "Aplasia hypoplasia involving the femoral head and neck", "Aplasia hypoplasia involving the metacarpal bones", "Aplasia hypoplasia involving the musculature of the upper limbs", "Aplasia hypoplasia involving the nose", "Aplasia hypoplasia involving the pelvis", "Aplasia hypoplasia involving the sinuses", "Aplasia hypoplasia involving the skeletal musculature", "Aplasia hypoplasia involving the skeleton", "Aplasia hypoplasia involving the vertebral column", "Aplasia hypoplasia of fingers", "Aplasia hypoplasia of metatarsal bones", "Aplasia hypoplasia of the 4th metacarpal", "Aplasia hypoplasia of the 5th finger", "Aplasia hypoplasia of the 5th metacarpal", "Aplasia hypoplasia of the abdominal wall musculature", "Aplasia hypoplasia of the bladder", "Aplasia hypoplasia of the breasts", "Aplasia hypoplasia of the capital femoral epiphysis", "Aplasia hypoplasia of the cerebellar vermis", "Aplasia hypoplasia of the cerebellum", "Aplasia hypoplasia of the cerebral white matter", "Aplasia hypoplasia of the clavicles", "Aplasia hypoplasia of the colon", "Aplasia hypoplasia of the distal phalanges of the hand", "Aplasia hypoplasia of the distal phalanx of the thumb", "Aplasia hypoplasia of the ear", "Aplasia hypoplasia of the earlobes", "Aplasia hypoplasia of the epiglottis", "Aplasia hypoplasia of the extremities", "Aplasia hypoplasia of the eyebrow", "Aplasia hypoplasia of the eyelid", "Aplasia hypoplasia of the femur", "Aplasia hypoplasia of the fibula", "Aplasia hypoplasia of the gallbladder", "Aplasia hypoplasia of the hallux", "Aplasia hypoplasia of the humerus", "Aplasia hypoplasia of the lungs", "Aplasia hypoplasia of the nails", "Aplasia hypoplasia of the nasal bone", "Aplasia hypoplasia of the nasal septum", "Aplasia hypoplasia of the nipples", "Aplasia hypoplasia of the optic nerve", "Aplasia hypoplasia of the ovary", "Aplasia hypoplasia of the palmar creases", "Aplasia hypoplasia of the patella", "Aplasia hypoplasia of the phalanges of the hand", "Aplasia hypoplasia of the phalanges of the thumb", "Aplasia hypoplasia of the phalanges of the toes", "Aplasia hypoplasia of the proximal phalanges of the hand", "Aplasia hypoplasia of the pubic bone", "Aplasia hypoplasia of the radius", "Aplasia hypoplasia of the retina", "Aplasia hypoplasia of the ribs", "Aplasia hypoplasia of the sacrum", "Aplasia hypoplasia of the scapulae", "Aplasia hypoplasia of the skin", "Aplasia hypoplasia of the spleen", "Aplasia hypoplasia of the sternum", "Aplasia hypoplasia of the thumb", "Aplasia hypoplasia of the thymus", "Aplasia hypoplasia of the thyroid gland", "Aplasia hypoplasia of the tibia", "Aplasia hypoplasia of the tongue", "Aplasia hypoplasia of the tragus", "Aplasia hypoplasia of the ulna", "Aplasia hypoplasia of the uterus", "Aplasia hypoplasia of the uvula", "Aplasia hypoplasia of the vagina", "Aplasia hypoplasia of toe", "Aplasia involving bones of the extremities", "Aplasia involving bones of the lower limbs", "Aplasia of the fingers", "Aplasia of the middle phalanx of the hand", "Aplasia of the phalanges of the hand", "Aplasia of the phalanges of the toes", "Aplasia of the uterus", "Aplastic anemia", "Aplastic clavicle", "Aplastic hypoplastic lacrimal glands", "Aplastic hypoplastic toenail", "Apnea", "Apneic episodes precipitated by illness fatigue stress", "Appendicular hypotonia", "Apraxia", "Aqueductal stenosis", "Arachnodactyly", "Arachnoid hemangiomatosis", "Areflexia", "Areflexia of lower limbs", "Arm dystonia", "Arnold chiari malformation", "Arnold chiari type i malformation", "Arrhinencephaly", "Arteria lusoria", "Arterial dissection", "Arterial rupture", "Arterial stenosis", "Arterial thrombosis", "Arteriosclerosis", "Arteriovenous malformation", "Arthralgia", "Arthritis", "Arthrogryposis multiplex congenita", "Arthropathy", "Ascending aortic dissection", "Ascending tubular aorta aneurysm", "Ascites", "Aspiration", "Aspiration pneumonia", "Asterixis", "Asthenia", "Asthma", "Astigmatism", "Astrocytoma", "Astrocytosis", "Asymmetric growth", "Asymmetric septal hypertrophy", "Asymmetry of the ears", "Atelectasis", "Athetosis", "Atlantoaxial abnormality", "Atlantoaxial dislocation", "Atlantoaxial instability", "Atonic seizure", "Atopic dermatitis", "Atresia of the external auditory canal", "Atrial arrhythmia", "Atrial flutter", "Atrioventricular canal defect", "Atrophic scars", "Atrophy degeneration affecting the brainstem", "Atrophy degeneration affecting the central nervous system", "Atrophy degeneration affecting the cerebrum", "Atrophy degeneration involving the caudate nucleus", "Atrophy degeneration involving the corticospinal tracts", "Atrophy degeneration involving the spinal cord", "Attention deficit hyperactivity disorder", "Attenuation of retinal blood vessels", "Atypical absence seizure", "Auditory hallucinations", "Autism", "Autistic behavior", "Autoamputation", "Autoamputation of digits", "Autoimmune antibody positivity", "Autoimmune hemolytic anemia", "Autoimmune thrombocytopenia", "Autoimmunity", "Autosomal dominant germline de novo mutation", "Avascular necrosis", "Avascular necrosis of the capital femoral epiphysis", "Axial dystonia", "Axial muscle weakness", "Axillary pterygium", "Axonal degeneration", "Axonal degeneration regeneration", "Axonal loss", "Axonal regeneration", "Azoospermia", "B cell lymphoma", "B lymphocytopenia", "Babinski sign", "Back pain", "Bacterial endocarditis", "Barrel shaped chest", "Barrett esophagus", "Basal cell carcinoma", "Basal ganglia calcification", "Basal ganglia cysts", "Basal ganglia gliosis", "Beaded ribs", "Beaking of vertebral bodies", "Bell shaped thorax", "Benign neoplasm of the central nervous system", "Biconcave vertebral bodies", "Bicornuate uterus", "Bifid nasal tip", "Bifid ribs", "Bifid scrotum", "Bifid tongue", "Bifid uterus", "Bifid uvula", "Bilateral cleft lip", "Bilateral cleft lip and palate", "Bilateral cleft palate", "Bilateral coxa valga", "Bilateral cryptorchidism", "Bilateral external ear deformity", "Bilateral microphthalmos", "Bilateral polymicrogyria", "Bilateral ptosis", "Bilateral sensorineural hearing impairment", "Bilateral single transverse palmar creases", "Bilateral talipes equinovarus", "Bilateral tonic clonic seizure", "Bilateral tonic clonic seizure with focal onset", "Bilateral tonic clonic seizure with generalized onset", "Bile duct proliferation", "Biliary atresia", "Biliary cirrhosis", "Biliary tract abnormality", "Biliary tract neoplasm", "Bimanual synkinesia", "Biparietal narrowing", "Bird like facies", "Birth length greater than 97th percentile", "Birth length less than 3rd percentile", "Biventricular hypertrophy", "Bladder diverticulum", "Bladder neoplasm", "Bleeding with minor or no trauma", "Blepharitis", "Blepharophimosis", "Blindness", "Blistering by anatomical location", "Blistering by histological location", "Bloodstream infectious agent", "Bloody diarrhea", "Blue irides", "Blue nevus", "Blue sclerae", "Blurred vision", "Bone cyst", "Bone fracture", "Bone marrow foam cells", "Bone marrow hypercellularity", "Bone marrow hypocellularity", "Bone pain", "Bone spicule pigmentation of the retina", "Bowel diverticulosis", "Bowing of the arm", "Bowing of the legs", "Brachycephaly", "Brachydactyly", "Brachyturricephaly", "Bradycardia", "Bradykinesia", "Brain imaging abnormality", "Brain neoplasm", "Brain stem compression", "Branchial anomaly", "Branchial cyst", "Branchial fistula", "Breast aplasia", "Breast carcinoma", "Breast hypoplasia", "Breathing dysregulation", "Breech presentation", "Brisk reflexes", "Brittle hair", "Broad alveolar ridges", "Broad based gait", "Broad chin", "Broad clavicles", "Broad columella", "Broad distal phalanx of finger", "Broad eyebrow", "Broad face", "Broad femoral neck", "Broad finger", "Broad foot", "Broad forehead", "Broad jaw", "Broad long bones", "Broad metacarpals", "Broad nail", "Broad nasal tip", "Broad neck", "Broad palm", "Broad philtrum", "Broad ribs", "Broad thumb", "Broad toe", "Bronchiectasis", "Bronchitis", "Bronchomalacia", "Bronchospasm", "Bruising susceptibility", "Brushfield spots", "Bruxism", "Bulbar palsy", "Bulbar signs", "Bulbous nose", "Bull s eye maculopathy", "Bundle branch block", "Burkitt lymphoma", "Butterfly vertebrae", "Cachexia", "Caesarian section", "Cafe au lait spot", "Calcific stippling", "Calcification of the aorta", "Calcinosis", "Calcium nephrolithiasis", "Calcium oxalate nephrolithiasis", "Calvarial hyperostosis", "Calvarial osteosclerosis", "Calvarial skull defect", "Camptodactyly of toe", "Capillary hemangioma", "Capillary malformation", "Capitate hamate fusion", "Carcinoid tumor", "Carcinoma", "Cardiac arrest", "Cardiac conduction abnormality", "Cardiac diverticulum", "Cardiac rhabdomyoma", "Cardiac shunt", "Cardiac valve calcification", "Cardiomegaly", "Cardiorespiratory arrest", "Cardiovascular calcification", "Carious teeth", "Carpal bone hypoplasia", "Carpal synostosis", "Cataplexy", "Caudate atrophy", "Cavernous hemangioma", "Cavum septum pellucidum", "Celiac disease", "Cellular immunodeficiency", "Cellulitis", "Central adrenal insufficiency", "Central apnea", "Central diabetes insipidus", "Central heterochromia", "Central hypothyroidism", "Central hypoventilation", "Central nervous system cyst", "Central opacification of the cornea", "Central primitive neuroectodermal tumor", "Central scotoma", "Central sleep apnea", "Centrally nucleated skeletal muscle fibers", "Centrocecal scotoma", "Cerebellar atrophy", "Cerebellar cortical atrophy", "Cerebellar cyst", "Cerebellar dysplasia", "Cerebellar hemorrhage", "Cerebellar hypoplasia", "Cerebellar malformation", "Cerebellar vermis atrophy", "Cerebral amyloid angiopathy", "Cerebral calcification", "Cerebral cortical atrophy", "Cerebral dysmyelination", "Cerebral edema", "Cerebral hamartoma", "Cerebral hemorrhage", "Cerebral hypomyelination", "Cerebral hypoplasia", "Cerebral inclusion bodies", "Cerebral palsy", "Cerebral venous thrombosis", "Cerebral visual impairment", "Cerebral white matter atrophy", "Cerebral white matter hypoplasia", "Cervical kyphosis", "Cervical myelopathy", "Cervical ribs", "Cervical spinal canal stenosis", "Cervical spine instability", "Cervical subluxation", "Cessation of head growth", "Cheilitis", "Cherry red spot of the macula", "Chest pain", "Chilblains", "Childhood onset", "Childhood onset sensorineural hearing impairment", "Childhood onset truncal obesity", "Chills", "Choanal stenosis", "Choking episodes", "Cholangitis", "Cholecystitis", "Cholestasis", "Cholestatic liver disease", "Chondrocalcinosis", "Chondrosarcoma", "Chordee", "Chorea", "Choreoathetosis", "Choriocarcinoma", "Chorioretinal atrophy", "Chorioretinal coloboma", "Chorioretinal degeneration", "Chorioretinal dysplasia", "Chorioretinal dystrophy", "Chorioretinal hypopigmentation", "Choroid plexus carcinoma", "Choroid plexus cyst", "Choroidal melanoma", "Choroidal neovascularization", "Chromosomal breakage induced by crosslinking agents", "Chromosomal breakage induced by ionizing radiation", "Chromosome breakage", "Chronic atrophic gastritis", "Chronic axonal neuropathy", "Chronic bronchitis", "Chronic constipation", "Chronic diarrhea", "Chronic fatigue", "Chronic hemolytic anemia", "Chronic hepatic failure", "Chronic infection", "Chronic kidney disease", "Chronic leukemia", "Chronic lung disease", "Chronic lymphatic leukemia", "Chronic mucocutaneous candidiasis", "Chronic neutropenia", "Chronic noninfectious lymphadenopathy", "Chronic oral candidiasis", "Chronic otitis media", "Chronic pulmonary obstruction", "Chronic rhinitis", "Chronic sinusitis", "Chylothorax", "Cirrhosis", "Cleft hard palate", "Cleft lip", "Cleft soft palate", "Cleft upper lip", "Clinodactyly", "Clitoral hypoplasia", "Clonic seizure", "Clonus", "Cloverleaf skull", "Clubbing", "Clubbing of fingers", "Clubbing of toes", "Clumsiness", "Cns demyelination", "Cns hypomyelination", "Coarctation of aorta", "Coarse facial features", "Coarse hair", "Cochlear malformation", "Cognitive impairment", "Cogwheel rigidity", "Cold induced muscle cramps", "Colitis", "Collectionism", "Coloboma", "Colon cancer", "Color vision defect", "Color vision test abnormality", "Colorectal polyposis", "Colpocephaly", "Coma", "Combined immunodeficiency", "Communicating hydrocephalus", "Complete atrioventricular canal defect", "Complete duplication of phalanx of hand", "Complex febrile seizure", "Concave nail", "Concave nasal ridge", "Concentric hypertrophic cardiomyopathy", "Cone cone rod dystrophy", "Cone shaped epiphyses of the phalanges of the hand", "Cone shaped epiphysis", "Confetti like hypopigmented macules", "Confusion", "Congenital adrenal hyperplasia", "Congenital bilateral hip dislocation", "Congenital blindness", "Congenital contracture", "Congenital craniofacial dysostosis", "Congenital diaphragmatic hernia", "Congenital hemolytic anemia", "Congenital hepatic fibrosis", "Congenital hip dislocation", "Congenital hypothyroidism", "Congenital ichthyosiform erythroderma", "Congenital localized absence of skin", "Congenital malformation of the great arteries", "Congenital malformation of the left heart", "Congenital malformation of the right heart", "Congenital muscular dystrophy", "Congenital muscular torticollis", "Congenital nonbullous ichthyosiform erythroderma", "Congenital nystagmus", "Congenital onset", "Congenital posterior urethral valve", "Congenital sensorineural hearing impairment", "Congenital stationary night blindness", "Congenital thrombocytopenia", "Congestive heart failure", "Conical tooth", "Conjugated hyperbilirubinemia", "Conjunctival hamartoma", "Connective tissue nevi", "Conspicuously happy disposition", "Constipation", "Constitutional symptom", "Constriction of peripheral visual field", "Contiguous gene syndrome", "Contractures involving the joints of the feet", "Contractures of the joints of the lower limbs", "Contractures of the joints of the upper limbs", "Contractures of the large joints", "Convex nasal ridge", "Coombs positive hemolytic anemia", "Cor pulmonale", "Corneal dystrophy", "Corneal erosion", "Corneal neovascularization", "Corneal opacity", "Corneal scarring", "Corneal ulceration", "Coronal cleft vertebrae", "Coronal craniosynostosis", "Coronary artery atherosclerosis", "Corpus callosum atrophy", "Cortical cataract", "Cortical dysplasia", "Cortical myoclonus", "Cortical thickening of long bone diaphyses", "Corticospinal tract hypoplasia", "Cough", "Coxa valga", "Coxa vara", "Crackles", "Cranial asymmetry", "Cranial hyperostosis", "Cranial nerve compression", "Craniofacial asymmetry", "Craniofacial dysostosis", "Craniofacial hyperostosis", "Craniofacial osteosclerosis", "Craniosynostosis", "Crumpled long bones", "Cryptorchidism", "Csf lymphocytic pleiocytosis", "Csf pleocytosis", "Cubitus valgus", "Cupped ear", "Cupped ribs", "Curly eyelashes", "Curly hair", "Cutaneous abscess", "Cutaneous cyst", "Cutaneous finger syndactyly", "Cutaneous melanoma", "Cutaneous photosensitivity", "Cutaneous syndactyly", "Cutaneous syndactyly of toes", "Cutis laxa", "Cutis marmorata", "Cyanosis", "Cyanotic episode", "Cyclopia", "Cystic hygroma", "Cystic liver disease", "Cystic renal dysplasia", "Cystinuria", "Cystoid macular edema", "Cytochrome c oxidase negative muscle fibers", "Dark urine", "Death in adolescence", "Death in adulthood", "Death in childhood", "Death in infancy", "Decerebrate rigidity", "Decreased absent ankle reflexes", "Decreased activity of mitochondrial complex i", "Decreased activity of mitochondrial complex ii", "Decreased activity of mitochondrial complex iii", "Decreased activity of mitochondrial complex iv", "Decreased activity of nadph oxidase", "Decreased activity of the pyruvate dehydrogenase complex", "Decreased adenosylcobalamin", "Decreased adipose tissue", "Decreased calvarial ossification", "Decreased cd4 cd8 ratio", "Decreased cervical spine flexion due to contractures of posterior cervical muscles", "Decreased circulating acth level", "Decreased circulating aldosterone level", "Decreased circulating androgen concentration", "Decreased circulating antibody level", "Decreased circulating copper concentration", "Decreased circulating cortisol level", "Decreased circulating follicle stimulating hormone concentration", "Decreased circulating gaba concentration", "Decreased circulating gonadotropin concentration", "Decreased circulating iga level", "Decreased circulating igg level", "Decreased circulating igg subclass level", "Decreased circulating level of specific antibody", "Decreased circulating progesterone", "Decreased circulating total iga", "Decreased circulating total igg", "Decreased circulating total igm", "Decreased corneal reflex", "Decreased facial expression", "Decreased fertility", "Decreased fertility in females", "Decreased fertility in males", "Decreased head circumference", "Decreased lacrimation", "Decreased ldl cholesterol concentration", "Decreased libido", "Decreased light and dark adapted electroretinogram amplitude", "Decreased lymphocyte apoptosis", "Decreased lymphocyte proliferation in response to mitogen", "Decreased mean corpuscular volume", "Decreased methylcobalamin", "Decreased methylmalonyl coa mutase activity", "Decreased muscle mass", "Decreased number of large peripheral myelinated nerve fibers", "Decreased number of peripheral myelinated nerve fibers", "Decreased palmar creases", "Decreased patellar reflex", "Decreased plasma carnitine", "Decreased proportion of cd3 positive t cells", "Decreased proportion of cd4 positive helper t cells", "Decreased pulmonary function", "Decreased serum complement c3", "Decreased serum insulin like growth factor 1", "Decreased serum iron", "Decreased size of nerve terminals", "Decreased specific anti polysaccharide antibody level", "Decreased specific antibody response to protein vaccine", "Decreased specific antibody response to vaccination", "Decreased specific pneumococcal antibody level", "Decreased testicular size", "Decreased urine output", "Deep palmar crease", "Deep philtrum", "Deep plantar creases", "Deep set nails", "Deep venous thrombosis", "Deeply set eye", "Defective dna repair after ultraviolet radiation damage", "Defective t cell proliferation", "Deformed rib cage", "Deformed sella turcica", "Deformed tarsal bones", "Degeneration of the lateral corticospinal tracts", "Degeneration of the striatum", "Dehydration", "Delayed ability to roll over", "Delayed ability to sit", "Delayed ability to stand", "Delayed ability to walk", "Delayed closure of the anterior fontanelle", "Delayed cns myelination", "Delayed cranial suture closure", "Delayed epiphyseal ossification", "Delayed eruption of permanent teeth", "Delayed eruption of primary teeth", "Delayed eruption of teeth", "Delayed fine motor development", "Delayed gross motor development", "Delayed menarche", "Delayed myelination", "Delayed ossification of carpal bones", "Delayed puberty", "Delayed social development", "Delirium", "Delusions", "Dementia", "Demyelinating peripheral neuropathy", "Dental crowding", "Dental malocclusion", "Depletion of mitochondrial dna in muscle tissue", "Deposits immunoreactive to beta amyloid protein", "Depressed nasal bridge", "Depressed nasal ridge", "Depressed nasal tip", "Depression", "Dermal atrophy", "Dermal translucency", "Dermatological manifestations of systemic disorders", "Descending aortic dissection", "Desquamation of skin soon after birth", "Developmental cataract", "Developmental glaucoma", "Developmental regression", "Developmental stagnation", "Deviated nasal septum", "Deviation of the 2nd finger", "Deviation of the 3rd finger", "Deviation of the hallux", "Deviation of the hand or of fingers of the hand", "Deviation of the thumb", "Deviation of toes", "Diabetes insipidus", "Dialeptic seizure", "Diaphragmatic eventration", "Diaphragmatic paralysis", "Diaphragmatic weakness", "Diaphyseal sclerosis", "Diaphyseal thickening", "Diarrhea", "Diastasis recti", "Diastema", "Dicarboxylic aciduria", "Difficulty climbing stairs", "Difficulty in tongue movements", "Difficulty running", "Difficulty standing", "Difficulty walking", "Diffuse alveolar hemorrhage", "Diffuse cerebellar atrophy", "Diffuse cerebral atrophy", "Diffuse mesangial sclerosis", "Diffuse palmoplantar hyperkeratosis", "Diffuse white matter abnormalities", "Digenic inheritance", "Dilatation of the cerebral artery", "Dilatation of the ventricular cavity", "Dilated cardiomyopathy", "Dilated fourth ventricle", "Dilated third ventricle", "Dilation of lateral ventricles", "Dilation of virchow robin spaces", "Diminished ability to concentrate", "Diminished motivation", "Diminished movement", "Diplopia", "Disinhibition", "Displacement of the urethral meatus", "Disproportionate short limb short stature", "Disproportionate short stature", "Disproportionate short trunk short stature", "Disproportionate tall stature", "Disseminated intravascular coagulation", "Distal amyotrophy", "Distal arthrogryposis", "Distal joint laxity", "Distal lower limb amyotrophy", "Distal lower limb muscle weakness", "Distal muscle weakness", "Distal peripheral sensory neuropathy", "Distal sensory impairment", "Distal sensory impairment of all modalities", "Distal sensory loss of all modalities", "Distal upper limb amyotrophy", "Distal upper limb muscle weakness", "Disturbance of facial expression", "Dolichocephaly", "Double aortic arch", "Down sloping shoulders", "Downslanted palpebral fissures", "Downturned corners of mouth", "Drowsiness", "Drusen", "Dry hair", "Dry skin", "Duodenal adenocarcinoma", "Duodenal atresia", "Duodenal stenosis", "Duplicated collecting system", "Duplication involving bones of the feet", "Duplication of hand bones", "Duplication of the distal phalanx of hand", "Duplication of thumb phalanx", "Dysarthria", "Dyscalculia", "Dyschromatopsia", "Dysdiadochokinesis", "Dysesthesia", "Dysgenesis of the cerebellar vermis", "Dysgerminoma", "Dysgraphia", "Dyskinesia", "Dyslexia", "Dysmenorrhea", "Dysmetria", "Dysmetric saccades", "Dysostosis multiplex", "Dyspareunia", "Dysphagia", "Dysphasia", "Dysphonia", "Dysplasia of the femoral head", "Dysplastic corpus callosum", "Dyspnea", "Dystonia", "Dystrophic fingernails", "Dystrophic toenail", "Dysuria", "Ear pain", "Early onset absence seizures", "Early onset of sexual maturation", "Easy fatigability", "Ecchymosis", "Echolalia", "Eclabion", "Eclampsia", "Ectodermal dysplasia", "Ectopia lentis", "Ectopia pupillae", "Ectopic anus", "Ectopic calcification", "Ectopic kidney", "Ectrodactyly", "Ectropion", "Ectropion of lower eyelids", "Eczema", "Eczematoid dermatitis", "Edema of the dorsum of feet", "Edema of the dorsum of hands", "Eeg with abnormally slow frequencies", "Eeg with burst suppression", "Eeg with continuous slow activity", "Eeg with focal epileptiform discharges", "Eeg with focal sharp slow waves", "Eeg with focal sharp waves", "Eeg with focal spike waves", "Eeg with focal spikes", "Eeg with frontal epileptiform discharges", "Eeg with generalized sharp slow waves", "Eeg with generalized slow activity", "Eeg with irregular generalized spike and wave complexes", "Eeg with multifocal slow activity", "Eeg with polyspike wave complexes", "Eeg with spike wave complexes", "Elbow ankylosis", "Elbow flexion contracture", "Elevated alkaline phosphatase of bone origin", "Elevated calcitonin", "Elevated circulating alanine aminotransferase concentration", "Elevated circulating aspartate aminotransferase concentration", "Elevated circulating follicle stimulating hormone level", "Elevated circulating glutaric acid concentration", "Elevated circulating growth hormone concentration", "Elevated circulating long chain fatty acid concentration", "Elevated circulating parathyroid hormone level", "Elevated circulating thyroid stimulating hormone concentration", "Elevated creatine kinase after exercise", "Elevated diastolic blood pressure", "Elevated gamma glutamyltransferase level", "Elevated hemoglobin a1c", "Elevated hepatic transaminase", "Elevated lactate pyruvate ratio", "Elevated mean arterial pressure", "Elevated proportion of cd4 negative cd8 negative alpha beta regulatory t cells", "Elevated pulmonary artery pressure", "Elevated serum acid phosphatase", "Elevated systolic blood pressure", "Elevated tissue non specific alkaline phosphatase", "Elevated total serum tryptase", "Elevated urinary carboxylic acid", "Elevated urinary delta aminolevulinic acid", "Elevated urinary dicarboxylic acid level", "Elevated urinary monocarboxylic acid level", "Elfin facies", "Elliptocytosis", "Elongated superior cerebellar peduncle", "Embryonal neoplasm", "Embryonal renal neoplasm", "Emg abnormality", "Emg axonal abnormality", "Emg chronic denervation signs", "Emg decremental response of compound muscle action potential to repetitive nerve stimulation", "Emg impaired neuromuscular transmission", "Emg myopathic abnormalities", "Emg neuropathic changes", "Emg slow motor conduction", "Emotional lability", "Emphysema", "Enamel hypoplasia", "Encephalocele", "Encephalopathy", "Enchondroma", "Endocardial fibrosis", "Endocarditis", "Enlarged cerebellum", "Enlarged cisterna magna", "Enlarged joints", "Enlarged kidney", "Enlarged metaphyses", "Enlarged ovaries", "Enlarged posterior fossa", "Enlarged thorax", "Enlarged tonsils", "Enlargement of the costochondral junction", "Enlargement of the wrists", "Enterocolitis", "Enthesitis", "Entropion", "Enuresis", "Ependymoma", "Epicanthus", "Epicanthus inversus", "Epidermal acanthosis", "Epidermal hyperkeratosis", "Epidermal nevus", "Epidermoid cyst", "Epigastric pain", "Epileptic encephalopathy", "Epileptic spasm", "Epiphora", "Epiphyseal dysplasia", "Epiphyseal stippling", "Epiretinal membrane", "Episodic ataxia", "Episodic hyperhidrosis", "Episodic hypertension", "Episodic pain", "Episodic tachypnea", "Episodic vomiting", "Epispadias", "Epistaxis", "Equinovarus deformity", "Equinus calcaneus", "Erectile dysfunction", "Erlenmeyer flask deformity of the femurs", "Eruption failure", "Erysipelas", "Erythema", "Erythema nodosum", "Erythematous plaque", "Erythrocyte inclusion bodies", "Erythroderma", "Erythroid hyperplasia", "Erythroid hypoplasia", "Esodeviation", "Esophageal atresia", "Esophageal neoplasm", "Esophageal stenosis", "Esophageal stricture", "Esophageal varix", "Esophagitis", "Ethylmalonic aciduria", "Eunuchoid habitus", "Euryblepharon", "Eversion of lateral third of lower eyelids", "Everted upper lip vermilion", "Exaggerated cupid s bow", "Exaggerated startle response", "Exanthem", "Excessive daytime somnolence", "Excessive salivation", "Excessive wrinkled skin", "Excessive wrinkling of palmar skin", "Exercise induced muscle cramps", "Exercise induced muscle fatigue", "Exercise induced muscle stiffness", "Exercise induced myalgia", "Exercise induced myoglobinuria", "Exercise induced rhabdomyolysis", "Exercise intolerance", "Exertional dyspnea", "Exodeviation", "Exostoses", "Expressive aphasia", "Expressive language delay", "External ear malformation", "External genital hypoplasia", "External ophthalmoplegia", "Extra axial cerebrospinal fluid accumulation", "Extrahepatic cholestasis", "Extramedullary hematopoiesis", "Extrapyramidal dyskinesia", "Extrapyramidal muscular rigidity", "Exudative retinal detachment", "Eyelid coloboma", "Eyelid myoclonus", "Facial asymmetry", "Facial capillary hemangioma", "Facial cleft", "Facial diplegia", "Facial edema", "Facial erythema", "Facial grimacing", "Facial hemangioma", "Facial hyperostosis", "Facial hypertrichosis", "Facial hypotonia", "Facial shape deformation", "Facial telangiectasia", "Failure of eruption of permanent teeth", "Failure to thrive", "Failure to thrive in infancy", "Fair hair", "Falls", "Fasciculations", "Fasting hyperinsulinemia", "Fasting hypoglycemia", "Fat malabsorption", "Fatigable weakness of bulbar muscles", "Fatigable weakness of distal limb muscles", "Fatigable weakness of respiratory muscles", "Fatigable weakness of skeletal muscles", "Fatigable weakness of swallowing muscles", "Fatiguable weakness of proximal limb muscles", "Fatigue", "Fatty replacement of skeletal muscle", "Feeding difficulties", "Feeding difficulties in infancy", "Female external genitalia in individual with 46 xy karyotype", "Female hypogonadism", "Female infertility", "Female reproductive system neoplasm", "Female sexual dysfunction", "Femoral bowing", "Femoral hernia", "Fetal akinesia sequence", "Fetal distress", "Fetal onset", "Fetal polyuria", "Fetal ultrasound soft marker", "Fever", "Fibroadenoma of the breast", "Fibrosarcoma", "Fibrous tissue neoplasm", "Fibular aplasia", "Fibular hypoplasia", "Fine hair", "Finger agnosia", "Finger clinodactyly", "Finger swelling", "Finger syndactyly", "Fingerprint intracellular accumulation of autofluorescent lipopigment storage material", "First degree atrioventricular block", "First dorsal interossei muscle weakness", "Flank pain", "Flared iliac wing", "Flared metaphysis", "Flared nostrils", "Flaring of rib cage", "Flat acetabular roof", "Flat cornea", "Flat face", "Flat forehead", "Flat nasal alae", "Flat occiput", "Flattened epiphysis", "Flattened femoral epiphysis", "Flattened femoral head", "Flexion contracture of digit", "Flexion contracture of thumb", "Fluctuations in consciousness", "Flushing", "Foam cells", "Focal aware seizure", "Focal cortical dysplasia", "Focal cortical dysplasia type ii", "Focal dystonia", "Focal emotional seizure", "Focal impaired awareness seizure", "Focal motor seizure", "Focal myoclonic seizure", "Focal non motor seizure", "Focal onset seizure", "Focal segmental glomerulosclerosis", "Focal t2 hyperintense basal ganglia lesion", "Focal t2 hyperintense brainstem lesion", "Focal tonic seizure", "Focal white matter lesions", "Follicular hyperkeratosis", "Follicular hyperplasia", "Follicular thyroid carcinoma", "Food allergy", "Food intolerance", "Foot acroosteolysis", "Foot dorsiflexor weakness", "Foot oligodactyly", "Fractures of the long bones", "Fragile nails", "Fragile skin", "Fragmented epiphyses", "Freckling", "Frequent falls", "Frontal balding", "Frontal cortical atrophy", "Frontal hirsutism", "Frontal lobe dementia", "Frontotemporal cerebral atrophy", "Frontotemporal dementia", "Full cheeks", "Fulminant hepatic failure", "Functional abnormality of male internal genitalia", "Functional abnormality of the gastrointestinal tract", "Functional abnormality of the inner ear", "Functional abnormality of the middle ear", "Functional intestinal obstruction", "Functional motor deficit", "Furrowed tongue", "Fused cervical vertebrae", "Gait ataxia", "Gait disturbance", "Gait imbalance", "Galactorrhea", "Gangrene", "Gastric ulcer", "Gastritis", "Gastroesophageal reflux", "Gastrointestinal atresia", "Gastrointestinal carcinoma", "Gastrointestinal hemorrhage", "Gastrointestinal infarctions", "Gastrointestinal inflammation", "Gastrointestinal obstruction", "Gastrointestinal stroma tumor", "Gastroparesis", "Gastrostomy tube feeding in infancy", "Gaze evoked horizontal nystagmus", "Gaze evoked nystagmus", "Generalized abnormality of skin", "Generalized aminoaciduria", "Generalized amyotrophy", "Generalized clonic seizure", "Generalized dystonia", "Generalized edema", "Generalized hirsutism", "Generalized hyperkeratosis", "Generalized hyperpigmentation", "Generalized hyperreflexia", "Generalized hypertrichosis", "Generalized hypopigmentation", "Generalized hypopigmentation of hair", "Generalized hypotonia", "Generalized joint laxity", "Generalized limb muscle atrophy", "Generalized lipodystrophy", "Generalized lymphadenopathy", "Generalized muscle weakness", "Generalized myoclonic atonic seizure", "Generalized myoclonic seizure", "Generalized neonatal hypotonia", "Generalized onset motor seizure", "Generalized onset seizure", "Generalized osteoporosis", "Generalized osteosclerosis", "Generalized tonic seizure", "Genetic anticipation", "Genital neoplasm", "Genu valgum", "Genu varum", "Germ cell neoplasia", "Germinoma", "Giant platelets", "Gingival bleeding", "Gingival fibromatosis", "Gingival overgrowth", "Gingival recession", "Gingivitis", "Glaucoma", "Glioblastoma multiforme", "Glioma", "Gliosis", "Global brain atrophy", "Glomerular deposits", "Glomerular sclerosis", "Glomerulonephritis", "Glomerulopathy", "Glomus jugular tumor", "Glossitis", "Glossoptosis", "Glucose intolerance", "Glutaric aciduria", "Glycosuria", "Goiter", "Gonadal dysgenesis", "Gonadal neoplasm", "Gonadoblastoma", "Gonosomal inheritance", "Gout", "Gowers sign", "Grammar specific speech disorder", "Granulocytopenia", "Granulomatosis", "Gray matter heterotopia", "Gynecomastia", "Hallucinations", "Hallux valgus", "Hamartoma", "Hamartoma of the eye", "Hamartoma of tongue", "Hamartomatous polyposis", "Hammertoe", "Hamstring contractures", "Hand apraxia", "Hand clenching", "Hand muscle weakness", "Hand oligodactyly", "Hand polydactyly", "Hand tremor", "Handgrip myotonia", "Happy demeanor", "Hashimoto thyroiditis", "Head banging", "Head titubation", "Head tremor", "Headache", "Heart block", "Heat intolerance", "Heinz bodies", "Hemangioblastoma", "Hemangiomatosis", "Hematological neoplasm", "Hemianopia", "Hemiatrophy", "Hemifacial spasm", "Hemihypertrophy", "Hemimegalencephaly", "Hemiparesis", "Hemiplegia hemiparesis", "Hemivertebrae", "Hemoglobinuria", "Hemolytic anemia", "Hemoptysis", "Hemorrhage of the eye", "Heparan sulfate excretion in urine", "Hepatic cysts", "Hepatic encephalopathy", "Hepatic failure", "Hepatic fibrosis", "Hepatic necrosis", "Hepatitis", "Hepatoblastoma", "Hepatocellular adenoma", "Hepatocellular carcinoma", "Hepatomegaly", "Hepatosplenomegaly", "Hereditary nonpolyposis colorectal carcinoma", "Hernia", "Heterochromia iridis", "Heterogeneous", "Heteronymous hemianopia", "Heterophoria", "Heterotaxy", "Heterotropia", "Hiatus hernia", "High anterior hairline", "High forehead", "High frequency hearing impairment", "High frequency sensorineural hearing impairment", "High hypermetropia", "High myopia", "High narrow palate", "High palate", "High pitched voice", "Highly arched eyebrow", "Hip contracture", "Hip dislocation", "Hip dysplasia", "Hip flexor weakness", "Hip osteoarthritis", "Hip pain", "Hip subluxation", "Hirsutism", "Hoarse cry", "Hoarse voice", "Hodgkin lymphoma", "Holoprosencephaly", "Homocystinuria", "Honeycomb lung", "Horizontal eyebrow", "Horizontal nystagmus", "Horizontal pendular nystagmus", "Horseshoe kidney", "Humeroradial synostosis", "Hydranencephaly", "Hydrocele testis", "Hydrocephalus", "Hydrops fetalis", "Hydroureter", "Hydroxyprolinuria", "Hyperactive deep tendon reflexes", "Hyperactive patellar reflex", "Hyperactivity", "Hyperacusis", "Hyperaldosteronism", "Hyperammonemia", "Hyperautofluorescent retinal lesion", "Hypercalcemia", "Hyperchloremic acidosis", "Hypercholesterolemia", "Hypercoagulability", "Hyperconvex fingernails", "Hyperconvex nail", "Hyperesthesia", "Hyperextensibility at wrists", "Hyperextensibility of the finger joints", "Hyperextensible skin", "Hypergalactosemia", "Hyperglycemia", "Hypergonadotropic hypogonadism", "Hypergranulosis", "Hyperhidrosis", "Hyperhomocystinemia", "Hyperinsulinemic hypoglycemia", "Hyperintensity of cerebral white matter on mri", "Hyperkalemia", "Hyperkeratosis", "Hyperketonemia", "Hyperkinetic movements", "Hyperlipidemia", "Hyperlipoproteinemia", "Hyperlordosis", "Hypermethioninemia", "Hypermetric saccades", "Hypermetropia", "Hypernatriuria", "Hyperorality", "Hyperostosis", "Hyperoxaluria", "Hyperparathyroidism", "Hyperphosphatemia", "Hyperphosphaturia", "Hyperpigmentation in sun exposed areas", "Hyperpigmentation of the skin", "Hyperpituitarism", "Hyperplasia of the maxilla", "Hyperreflexia", "Hyperreflexia in upper limbs", "Hypersomnia", "Hypersplenism", "Hypertelorism", "Hypertension associated with pheochromocytoma", "Hypertensive crisis", "Hyperthyroidism", "Hypertonia", "Hypertrichosis", "Hypertriglyceridemia", "Hypertrophic cardiomyopathy", "Hypertrophic nerve changes", "Hyperuricemia", "Hyperuricosuria", "Hyperventilation", "Hypoamylasemia", "Hypocalcemia", "Hypocalcemic seizures", "Hypocalcemic tetany", "Hypochloremia", "Hypocholesterolemia", "Hypochromia", "Hypochromic anemia", "Hypochromic microcytic anemia", "Hypodontia", "Hypoglycemic coma", "Hypoglycemic seizures", "Hypogonadism", "Hypogonadotropic hypogonadism", "Hypohidrosis", "Hypoinsulinemia", "Hypointensity of cerebral white matter on mri", "Hypokalemia", "Hypokalemic alkalosis", "Hypokalemic metabolic alkalosis", "Hypoketotic hypoglycemia", "Hypokinesia", "Hypolipidemia", "Hypolipoproteinemia", "Hypomelanotic macule", "Hypomethioninemia", "Hypometric saccades", "Hypomimic face", "Hypoparathyroidism", "Hypophosphatemia", "Hypophosphatemic rickets", "Hypopigmentation of the fundus", "Hypopigmentation of the skin", "Hypopigmented macule", "Hypopigmented skin patches", "Hypopituitarism", "Hypoplasia of penis", "Hypoplasia of teeth", "Hypoplasia of the brainstem", "Hypoplasia of the corpus callosum", "Hypoplasia of the ear cartilage", "Hypoplasia of the epiglottis", "Hypoplasia of the femoral head", "Hypoplasia of the fovea", "Hypoplasia of the frontal lobes", "Hypoplasia of the iris", "Hypoplasia of the musculature", "Hypoplasia of the odontoid process", "Hypoplasia of the olfactory bulb", "Hypoplasia of the pons", "Hypoplasia of the radius", "Hypoplasia of the uterus", "Hypoplasia of the vagina", "Hypoplasia of the ventral pons", "Hypoplastic anemia", "Hypoplastic aortic arch", "Hypoplastic cervical vertebrae", "Hypoplastic dermoepidermal hemidesmosomes", "Hypoplastic facial bones", "Hypoplastic female external genitalia", "Hypoplastic fifth fingernail", "Hypoplastic fifth toenail", "Hypoplastic fingernail", "Hypoplastic frontal sinuses", "Hypoplastic heart", "Hypoplastic helices", "Hypoplastic hippocampus", "Hypoplastic ilia", "Hypoplastic iris stroma", "Hypoplastic labia majora", "Hypoplastic labia minora", "Hypoplastic nipples", "Hypoplastic pelvis", "Hypoplastic pubic rami", "Hypoplastic toenails", "Hypoplastic vertebral bodies", "Hypoproteinemia", "Hyporeflexia", "Hyporeflexia of lower limbs", "Hyporeflexia of upper limbs", "Hyposmia", "Hypotelorism", "Hypotension", "Hypothalamic gonadotropin releasing hormone deficiency", "Hypothalamic hamartoma", "Hypothalamic hypothyroidism", "Hypothermia", "Hypotriglyceridemia", "Hypouricemia", "Hypoventilation", "Hypovolemic shock", "Hypsarrhythmia", "Ichthyosis", "Ileus", "Immotile sperm", "Immunodeficiency", "Immunologic hypersensitivity", "Impacted tooth", "Impaired adp induced platelet aggregation", "Impaired antigen specific response", "Impaired collagen induced platelet aggregation", "Impaired distal proprioception", "Impaired distal tactile sensation", "Impaired distal vibration sensation", "Impaired epinephrine induced platelet aggregation", "Impaired glucose tolerance", "Impaired horizontal smooth pursuit", "Impaired mastication", "Impaired neutrophil bactericidal activity", "Impaired oropharyngeal swallow response", "Impaired pain sensation", "Impaired proprioception", "Impaired smooth pursuit", "Impaired social interactions", "Impaired t cell function", "Impaired tactile sensation", "Impaired tandem gait", "Impaired temperature sensation", "Impaired use of nonverbal behaviors", "Impaired vibration sensation at ankles", "Impaired vibration sensation in the lower limbs", "Impaired vibratory sensation", "Impaired visuospatial constructive cognition", "Impairment in personality functioning", "Impairment of activities of daily living", "Impotence", "Inability to walk", "Inappropriate antidiuretic hormone secretion", "Inappropriate behavior", "Inappropriate crying", "Inappropriate laughter", "Incisor macrodontia", "Incomitant strabismus", "Incomplete partition of the cochlea type ii", "Incomplete penetrance", "Incoordination", "Increased adipose tissue", "Increased arm span", "Increased aspartate family amino acid level in urine", "Increased b cell count", "Increased blood pressure", "Increased blood urea nitrogen", "Increased body mass index", "Increased body weight", "Increased bone mineral density", "Increased c peptide level", "Increased cerebral lipofuscin", "Increased circulating acth level", "Increased circulating androgen concentration", "Increased circulating antibody level", "Increased circulating cortisol level", "Increased circulating gonadotropin level", "Increased circulating iga level", "Increased circulating igg level", "Increased circulating igm level", "Increased circulating lactate dehydrogenase concentration", "Increased circulating prolactin concentration", "Increased circulating renin level", "Increased connective tissue", "Increased csf lactate", "Increased density of long bones", "Increased endomysial connective tissue", "Increased fecal porphyrin", "Increased female libido", "Increased head circumference", "Increased hepatic glycogen content", "Increased hepatocellular lipid droplets", "Increased intracranial pressure", "Increased intramyocellular lipid droplets", "Increased laxity of ankles", "Increased ldl cholesterol concentration", "Increased level of hippuric acid in urine", "Increased level of l fucose in urine", "Increased mean corpuscular hemoglobin concentration", "Increased mean corpuscular volume", "Increased megakaryocyte count", "Increased muscle fatiguability", "Increased muscle glycogen content", "Increased muscle lipid content", "Increased nuchal translucency", "Increased overbite", "Increased proportion of cd25 mast cells", "Increased proteinogenic amino acid level in urine", "Increased sensitivity to ionizing radiation", "Increased serine family amino acid in urine", "Increased serum iron", "Increased serum lactate", "Increased serum pyruvate", "Increased serum serotonin", "Increased serum testosterone level", "Increased skull ossification", "Increased sulfur amino acid level in urine", "Increased susceptibility to fractures", "Increased theta frequency activity in eeg", "Increased total bilirubin", "Increased urinary cortisol level", "Increased urinary non proteinogenic amino acid level", "Increased urine alpha ketoglutarate concentration", "Increased urine proteinogenic amino acid derivative level", "Increased vertebral height", "Ineffective esophageal peristalsis", "Infantile axial hypotonia", "Infantile encephalopathy", "Infantile muscular hypotonia", "Infantile onset", "Infantile spasms", "Infection related seizure", "Infectious encephalitis", "Inferior lens subluxation", "Inferior vermis hypoplasia", "Infertility", "Inflammation of the large intestine", "Inflammatory abnormality of the eye", "Inflexible adherence to routines or rituals", "Inguinal hernia", "Insidious onset", "Insomnia", "Inspiratory stridor", "Insulin resistance", "Insulin resistant diabetes mellitus", "Intellectual disability borderline", "Intellectual disability mild", "Intellectual disability moderate", "Intellectual disability profound", "Intellectual disability progressive", "Intellectual disability severe", "Intercostal muscle weakness", "Interictal eeg abnormality", "Intermittent diarrhea", "Internally nucleated skeletal muscle fibers", "Interrupted aortic arch", "Interstitial cardiac fibrosis", "Interstitial pneumonitis", "Intestinal atresia", "Intestinal fistula", "Intestinal hypoplasia", "Intestinal malrotation", "Intestinal polyp", "Intestinal pseudo obstruction", "Intraalveolar phospholipid accumulation", "Intracellular accumulation of autofluorescent lipopigment storage material", "Intracranial hemorrhage", "Intracranial meningioma", "Intractable diarrhea", "Intrauterine growth retardation", "Intrinsic hand muscle atrophy", "Intussusception", "Inverted nipples", "Involuntary movements", "Iridocyclitis", "Iris atrophy", "Iris coloboma", "Iris hypopigmentation", "Iron accumulation in brain", "Iron accumulation in globus pallidus", "Iron deficiency anemia", "Irregular epiphyses", "Irregular femoral epiphysis", "Irregular hyperpigmentation", "Irregular menstruation", "Irregular vertebral endplates", "Irritability", "Ischemic stroke", "J shaped sella turcica", "Jaundice", "Jerky head movements", "Joint contracture of the hand", "Joint contractures involving the joints of the feet", "Joint dislocation", "Joint hemorrhage", "Joint hyperflexibility", "Joint hypermobility", "Joint laxity", "Joint stiffness", "Joint subluxation", "Joint swelling", "Juvenile aseptic necrosis", "Juvenile cataract", "Juvenile myelomonocytic leukemia", "Juvenile onset", "Juvenile rheumatoid arthritis", "Keloids", "Keratitis", "Keratoconjunctivitis", "Keratosis pilaris", "Ketoacidosis", "Ketonuria", "Ketosis", "Ketotic hypoglycemia", "Kinetic tremor", "Knee clonus", "Knee dislocation", "Knee flexion contracture", "Kyphoscoliosis", "Kyphosis", "Labial hypertrophy", "Lack of insight", "Lack of peer relationships", "Lack of skin elasticity", "Lack of t cell function", "Lacrimal duct atresia", "Lacrimal duct stenosis", "Lacrimation abnormality", "Lactic acidosis", "Lacticaciduria", "Lactose intolerance", "Lagopthalmos", "Lambdoidal craniosynostosis", "Language impairment", "Large basal ganglia", "Large beaked nose", "Large earlobe", "Large face", "Large fleshy ears", "Large for gestational age", "Large foramen magnum", "Large forehead", "Large hands", "Large intestinal polyposis", "Large placenta", "Large sella turcica", "Laryngeal cleft", "Laryngeal dystonia", "Laryngeal hypoplasia", "Laryngeal stenosis", "Laryngeal stridor", "Laryngomalacia", "Laryngotracheomalacia", "Late onset", "Lateral clavicle hook", "Left atrial enlargement", "Left to right shunt", "Left ventricular hypertrophy", "Left ventricular noncompaction cardiomyopathy", "Left ventricular outflow tract obstruction", "Left ventricular systolic dysfunction", "Leg muscle stiffness", "Leiomyosarcoma", "Lens subluxation", "Lethal skeletal dysplasia", "Lethargy", "Leukemia", "Leukocytosis", "Leukodystrophy", "Leukoencephalopathy", "Leukonychia", "Leukopenia", "Lewy bodies", "Leydig cell neoplasia", "Lichenification", "Limb ataxia", "Limb dystonia", "Limb fasciculations", "Limb girdle muscle atrophy", "Limb girdle muscle weakness", "Limb girdle muscular dystrophy", "Limb hypertonia", "Limb joint contracture", "Limb muscle weakness", "Limb myoclonus", "Limb pain", "Limb tremor", "Limb undergrowth", "Limitation of joint mobility", "Limitation of knee mobility", "Limitation of movement at ankles", "Limitation of neck motion", "Limited elbow extension", "Limited elbow movement", "Limited extraocular movements", "Limited hip extension", "Limited hip movement", "Limited wrist movement", "Lingual dystonia", "Lipid accumulation in hepatocytes", "Lipoatrophy", "Lipodystrophy", "Lipoma", "Lissencephaly", "Localized hirsutism", "Localized osteoporosis", "Localized skin lesion", "Long clavicles", "Long ear", "Long eyelashes", "Long fingers", "Long foot", "Long hallux", "Long neck", "Long nose", "Long palm", "Long palpebral fissure", "Long penis", "Long philtrum", "Long thorax", "Long toe", "Long tract signs", "Lop ear", "Loss of ability to walk", "Loss of consciousness", "Loss of eyelashes", "Loss of purkinje cells in the cerebellar vermis", "Loss of speech", "Loss of subcutaneous adipose tissue in limbs", "Loss of voice", "Low alkaline phosphatase", "Low anterior hairline", "Low apgar score", "Low back pain", "Low frustration tolerance", "Low grade fever", "Low hanging columella", "Low levels of vitamin d", "Low posterior hairline", "Low set nipples", "Low set posteriorly rotated ears", "Lower extremity joint dislocation", "Lower eyelid coloboma", "Lower limb amyotrophy", "Lower limb asymmetry", "Lower limb hyperreflexia", "Lower limb hypertonia", "Lower limb metaphyseal irregularity", "Lower limb muscle weakness", "Lower limb pain", "Lower limb spasticity", "Lower limb undergrowth", "Lumbar hyperlordosis", "Lumbar kyphosis", "Lumbar scoliosis", "Lung adenocarcinoma", "Lymphangiectasis", "Lymphangioma", "Lymphedema", "Lymphocytosis", "Lymphoma", "Lymphopenia", "Lymphoproliferative disorder", "Macrocephaly at birth", "Macrocytic anemia", "Macrodactyly", "Macrodontia", "Macrodontia of permanent maxillary central incisor", "Macroglossia", "Macrogyria", "Macroorchidism", "Macroscopic hematuria", "Macrotia", "Macrovesicular hepatic steatosis", "Macular atrophy", "Macular coloboma", "Macular degeneration", "Macular hyperpigmentation", "Macular hypoplasia", "Macular purpura", "Macular thickening", "Macule", "Malabsorption", "Malar prominence", "Malar rash", "Male hypogonadism", "Male infertility", "Male pseudohermaphroditism", "Male reproductive system neoplasm", "Male sexual dysfunction", "Malignant genitourinary tract tumor", "Malignant hyperthermia", "Malignant neoplasm of the central nervous system", "Malnutrition", "Malrotation of small bowel", "Mandibular aplasia", "Mandibular prognathia", "Mania", "Mask like facies", "Mastoiditis", "Maternal hypertension", "Maturity onset diabetes of the young", "Meconium stained amniotic fluid", "Medial flaring of the eyebrow", "Median cleft lip", "Median cleft palate", "Mediastinal lymphadenopathy", "Medullary nephrocalcinosis", "Medulloblastoma", "Megalencephaly", "Megaloblastic anemia", "Megalocornea", "Melanocytic nevus", "Melanoma", "Melena", "Membranoproliferative glomerulonephritis", "Memory impairment", "Meningioma", "Meningitis", "Meningocele", "Menorrhagia", "Mental deterioration", "Mesomelia", "Metabolic acidosis", "Metabolic alkalosis", "Metacarpophalangeal joint contracture", "Metamorphopsia", "Metaphyseal chondrodysplasia", "Metaphyseal cupping", "Metaphyseal dysplasia", "Metaphyseal irregularity", "Metaphyseal sclerosis", "Metaphyseal striations", "Metaphyseal widening", "Metatarsal synostosis", "Metatarsus adductus", "Metatarsus valgus", "Methemoglobinemia", "Methylmalonic acidemia", "Methylmalonic aciduria", "Metopic synostosis", "Metrorrhagia", "Microcornea", "Microcytic anemia", "Microdontia", "Microglossia", "Micrographia", "Micromelia", "Micronodular cirrhosis", "Micropenis", "Microphallus", "Microretrognathia", "Microscopic hematuria", "Microtia third degree", "Microvesicular hepatic steatosis", "Middle age onset", "Midface retrusion", "Midline defect of the nose", "Migraine", "Mild global developmental delay", "Mild hearing impairment", "Mild microcephaly", "Mild postnatal growth retardation", "Mild short stature", "Mildly elevated creatine kinase", "Milia", "Minicore myopathy", "Minimal change glomerulonephritis", "Misalignment of incisors", "Missing ribs", "Mitochondrial inheritance", "Mitochondrial myopathy", "Mitochondrial respiratory chain defects", "Mitral stenosis", "Mitral valve calcification", "Mitral valve prolapse", "Mitten deformity", "Mixed demyelinating and axonal polyneuropathy", "Mixed hearing impairment", "Mixed hypo and hyperpigmentation of the skin", "Moderate albuminuria", "Moderate global developmental delay", "Moderate sensorineural hearing impairment", "Moderately reduced visual acuity", "Molar tooth sign on mri", "Molluscoid pseudotumors", "Molluscum contagiosum", "Monochromacy", "Monocytosis", "Monotonic speech", "Mood swings", "Morning glory anomaly", "Morning myoclonic jerks", "Morphological abnormality of the corticospinal tract", "Morphological abnormality of the middle ear", "Morphological abnormality of the pyramidal tract", "Mortality aging", "Motor axonal neuropathy", "Motor delay", "Motor deterioration", "Motor neuron atrophy", "Motor polyneuropathy", "Motor regression", "Motor seizure", "Motor tics", "Mottled pigmentation", "Movement abnormality of the tongue", "Moyamoya phenomenon", "Mucosal telangiectasiae", "Multicystic kidney dysplasia", "Multifactorial inheritance", "Multifocal cerebral white matter abnormalities", "Multifocal epileptiform discharges", "Multifocal seizures", "Multiple cafe au lait spots", "Multiple enchondromatosis", "Multiple gastric polyps", "Multiple impacted teeth", "Multiple joint contractures", "Multiple joint dislocation", "Multiple lentigines", "Multiple lipomas", "Multiple mitochondrial dna deletions", "Multiple myeloma", "Multiple prenatal fractures", "Multiple renal cysts", "Multiple rib fractures", "Multiple rows of eyelashes", "Multiple suture craniosynostosis", "Muscle abnormality related to mitochondrial dysfunction", "Muscle fiber atrophy", "Muscle fiber inclusion bodies", "Muscle fiber necrosis", "Muscle fiber splitting", "Muscle fiber tubular inclusions", "Muscle fibrillation", "Muscle flaccidity", "Muscle hypertrophy of the lower extremities", "Muscle spasm", "Muscle stiffness", "Muscle weakness", "Muscular dystrophy", "Muscular hypotonia of the trunk", "Muscular ventricular septal defect", "Mutism", "Myalgia", "Mydriasis", "Myelodysplasia", "Myelofibrosis", "Myeloid leukemia", "Myelomeningocele", "Myelopathy", "Myeloproliferative disorder", "Myocardial fibrosis", "Myoclonic seizure", "Myoclonic spasms", "Myoclonus", "Myofibrillar myopathy", "Myoglobinuria", "Myopathic facies", "Myopathy", "Myopia", "Myositis", "Myotonia", "Naevus flammeus of the eyelid", "Nail dysplasia", "Nail dystrophy", "Nail pits", "Narrow face", "Narrow foot", "Narrow forehead", "Narrow iliac wing", "Narrow internal auditory canal", "Narrow mouth", "Narrow nasal bridge", "Narrow nasal ridge", "Narrow nose", "Narrow palate", "Narrow palm", "Narrow palpebral fissure", "Narrow pelvis bone", "Narrow vertebral interpedicular distance", "Nasal congestion", "Nasal regurgitation", "Nasal speech", "Nasogastric tube feeding", "Nasogastric tube feeding in infancy", "Nasolacrimal duct obstruction", "Natal tooth", "Nausea", "Nausea and vomiting", "Neck flexor weakness", "Neck muscle weakness", "Negativism", "Nemaline bodies", "Neonatal alloimmune thrombocytopenia", "Neonatal asphyxia", "Neonatal breathing dysregulation", "Neonatal death", "Neonatal hyperbilirubinemia", "Neonatal hypoglycemia", "Neonatal hypotonia", "Neonatal insulin dependent diabetes mellitus", "Neonatal onset", "Neonatal respiratory distress", "Neoplasm", "Neoplasm by histology", "Neoplasm of fatty tissue", "Neoplasm of head and neck", "Neoplasm of striated muscle", "Neoplasm of the adrenal cortex", "Neoplasm of the adrenal gland", "Neoplasm of the breast", "Neoplasm of the colon", "Neoplasm of the ear", "Neoplasm of the endocrine system", "Neoplasm of the eye", "Neoplasm of the gallbladder", "Neoplasm of the gastrointestinal tract", "Neoplasm of the genitourinary tract", "Neoplasm of the heart", "Neoplasm of the inner ear", "Neoplasm of the large intestine", "Neoplasm of the larynx", "Neoplasm of the liver", "Neoplasm of the male external genitalia", "Neoplasm of the nervous system", "Neoplasm of the oral cavity", "Neoplasm of the pancreas", "Neoplasm of the parathyroid gland", "Neoplasm of the peripheral nervous system", "Neoplasm of the pituitary gland", "Neoplasm of the rectum", "Neoplasm of the respiratory system", "Neoplasm of the skeletal system", "Neoplasm of the skin", "Neoplasm of the small intestine", "Neoplasm of the stomach", "Neoplasm of the thyroid gland", "Neoplasm of the tongue", "Neoplasm of the tracheobronchial system", "Nephritis", "Nephrocalcinosis", "Nephrogenic diabetes insipidus", "Nephrolithiasis", "Nephronophthisis", "Nephropathy", "Nephrotic syndrome", "Neuralgia", "Neurodegeneration", "Neuroendocrine neoplasm", "Neurofibrillary tangles", "Neurofibromas", "Neurogenic bladder", "Neuroinflammation", "Neuromuscular dysphagia", "Neuronal loss in basal ganglia", "Neuronal loss in central nervous system", "Neuronal loss in the cerebral cortex", "Neuropathic arthropathy", "Neutropenia in presence of anti neutropil antibodies", "Neutrophilia", "Nevus", "Night sweats", "No social interaction", "Nocturia", "Nocturnal hypoventilation", "Nocturnal seizures", "Nodular goiter", "Non hodgkin lymphoma", "Non medullary thyroid carcinoma", "Non midline cleft lip", "Non midline cleft palate", "Non motor seizure", "Non obstructive azoospermia", "Noncommunicating hydrocephalus", "Noncompaction cardiomyopathy", "Nonimmune hydrops fetalis", "Nonketotic hypoglycemia", "Nonprogressive", "Nonprogressive cerebellar ataxia", "Nonprogressive encephalopathy", "Nonspherocytic hemolytic anemia", "Normochromic anemia", "Normocytic anemia", "Nuclear cataract", "Numerous nevi", "Numerous pigmented freckles", "Nyctalopia", "Nystagmus induced head nodding", "Obsessive compulsive behavior", "Obsessive compulsive trait", "Obstructive sleep apnea", "Occipital cortical atrophy", "Occipital encephalocele", "Occipital meningocele", "Ocular albinism", "Ocular anterior segment dysgenesis", "Ocular pain", "Oculogyric crisis", "Oculomotor apraxia", "Oculomotor nerve palsy", "Oligoarthritis", "Oligodactyly", "Oligodontia", "Oligohydramnios", "Oligomenorrhea", "Oligosacchariduria", "Oligospermia", "Oliguria", "Olivopontocerebellar atrophy", "Olivopontocerebellar hypoplasia", "Omphalocele", "Onion bulb formation", "Onset", "Onychogryposis", "Onychogryposis of toenails", "Onycholysis", "Onychomycosis", "Open angle glaucoma", "Open bite", "Open mouth", "Open operculum", "Ophthalmoparesis", "Opisthotonus", "Opportunistic infection", "Opsoclonus", "Optic atrophy", "Optic disc coloboma", "Optic disc hypoplasia", "Optic disc pallor", "Optic nerve dysplasia", "Optic nerve hypoplasia", "Optic neuropathy", "Oral aversion", "Oral cavity bleeding", "Oral cleft", "Oral leukoplakia", "Oral mucosal blisters", "Oral pharyngeal dysphagia", "Oral ulcer", "Orchitis", "Organic aciduria", "Orofacial dyskinesia", "Oromandibular dystonia", "Oromotor apraxia", "Oroticaciduria", "Orthopnea", "Orthostatic hypotension", "Orthostatic hypotension due to autonomic dysfunction", "Osteoarthritis", "Osteochondroma", "Osteochondrosis", "Osteolysis", "Osteolysis involving bones of the feet", "Osteolysis involving bones of the upper limbs", "Osteolytic defects of the distal phalanges of the hand", "Osteomalacia", "Osteomyelitis", "Osteopenia", "Osteopetrosis", "Osteoporosis", "Osteosarcoma", "Otitis media", "Otosclerosis", "Oval face", "Ovarian carcinoma", "Ovarian cyst", "Ovarian gonadoblastoma", "Ovarian neoplasm", "Ovarian papillary adenocarcinoma", "Overfolding of the superior helices", "Overfriendliness", "Overgrowth", "Overhanging nasal tip", "Overlapping fingers", "Overlapping toe", "Overriding aorta", "Overtubulated long bones", "Overweight", "Ovoid vertebral bodies", "Ovotestis", "Pace of progression", "Pain", "Pain in head and neck region", "Pain insensitivity", "Pallor", "Palmar hyperhidrosis", "Palmar pits", "Palmar telangiectasia", "Palmoplantar blistering", "Palmoplantar cutis laxa", "Palmoplantar hyperhidrosis", "Palpebral edema", "Palpitations", "Pancreatic adenocarcinoma", "Pancreatic cysts", "Pancreatic endocrine tumor", "Pancreatic fibrosis", "Pancreatic hypoplasia", "Pancreatic islet cell hyperplasia", "Pancreatitis", "Pancytopenia", "Panhypogammaglobulinemia", "Panhypopituitarism", "Panniculitis", "Papillary renal cell carcinoma", "Papillary thyroid carcinoma", "Papilledema", "Papilloma", "Papule", "Paracentral scotoma", "Paraganglioma", "Parakeratosis", "Paralysis", "Paranoia", "Paraparesis", "Paraplegia", "Paraplegia paraparesis", "Parasomnia", "Parathyroid adenoma", "Parathyroid carcinoma", "Parathyroid hyperplasia", "Paresthesia", "Parietal bossing", "Parietal cortical atrophy", "Parietal foramina", "Parkinsonism", "Parkinsonism with favorable response to dopaminergic medication", "Paronychia", "Paroxysmal bursts of laughter", "Paroxysmal dystonia", "Paroxysmal involuntary eye movements", "Paroxysmal ventricular tachycardia", "Partial agenesis of the corpus callosum", "Partial albinism", "Partial anomalous pulmonary venous return", "Partial duplication of the phalanx of hand", "Patchy alopecia", "Patchy changes of bone mineral density", "Patchy hypopigmentation of hair", "Patchy palmoplantar hyperkeratosis", "Patellar aplasia", "Patellar dislocation", "Patellar hypoplasia", "Patellar subluxation", "Patent ductus arteriosus", "Patent foramen ovale", "Pathologic fracture", "Pectus carinatum", "Pectus excavatum", "Pectus excavatum of inferior sternum", "Pedal edema", "Pediatric onset", "Pelvic girdle muscle weakness", "Pelvic kidney", "Pendular nystagmus", "Penetrating foot ulcers", "Peptic ulcer", "Perianal abscess", "Periauricular skin pits", "Pericardial effusion", "Pericarditis", "Perifoveal ring of hyperautofluorescence", "Perimembranous ventricular septal defect", "Periodic paralysis", "Periodontitis", "Periorbital edema", "Periorbital fullness", "Peripheral arterial stenosis", "Peripheral axonal degeneration", "Peripheral axonal neuropathy", "Peripheral cyanosis", "Peripheral demyelination", "Peripheral edema", "Peripheral hypermyelination", "Peripheral hypomyelination", "Peripheral neuropathy", "Peripheral opacification of the cornea", "Peripheral pulmonary artery stenosis", "Peripheral retinal avascularization", "Peripheral visual field loss", "Periportal fibrosis", "Perisylvian polymicrogyria", "Peritoneal abscess", "Peritonitis", "Periventricular cysts", "Periventricular heterotopia", "Periventricular leukomalacia", "Periventricular nodular heterotopia", "Periventricular white matter hyperintensities", "Peroneal muscle atrophy", "Perseveration", "Persistence of hemoglobin f", "Persistence of primary teeth", "Persistent ebv viremia", "Persistent head lag", "Personality changes", "Pes cavus", "Pes planus", "Pes valgus", "Petechiae", "Peters anomaly", "Pharyngitis", "Phenotypic variability", "Pheochromocytoma", "Phimosis", "Phocomelia", "Phonophobia", "Photophobia", "Photopsia", "Photoreceptor layer loss on macular oct", "Phthisis bulbi", "Physical urticaria", "Pierre robin sequence", "Pigmentary retinopathy", "Pili canaliculi", "Pili torti", "Pilomatrixoma", "Pineal cyst", "Pituitary adenoma", "Pituitary growth hormone cell adenoma", "Pituitary hypothyroidism", "Pituitary prolactin cell adenoma", "Plagiocephaly", "Plantar hyperkeratosis", "Platybasia", "Platyspondyly", "Pleural effusion", "Pleuritis", "Pneumonia", "Pneumothorax", "Poikilocytosis", "Poikiloderma", "Pointed chin", "Polar cataract", "Pollakisuria", "Polyarticular arthropathy", "Polycystic kidney dysplasia", "Polycystic liver disease", "Polycythemia", "Polydactyly", "Polygenic inheritance", "Polyhydramnios", "Polymicrogyria", "Polyneuropathy", "Polyphagia", "Polysplenia", "Polyuria", "Pontocerebellar atrophy", "Poor appetite", "Poor coordination", "Poor eye contact", "Poor fine motor coordination", "Poor gross motor coordination", "Poor head control", "Poor motor coordination", "Poor speech", "Poor suck", "Poor wound healing", "Porencephalic cyst", "Porokeratosis", "Porphyrinuria", "Portal fibrosis", "Portal vein thrombosis", "Positional foot deformity", "Positive romberg sign", "Post partum hemorrhage", "Postaxial foot polydactyly", "Postaxial hand polydactyly", "Postaxial polydactyly", "Posterior blepharitis", "Posterior embryotoxon", "Posterior fossa cyst", "Posterior pharyngeal cleft", "Posterior pituitary dysgenesis", "Posterior polar cataract", "Posterior subcapsular cataract", "Posteriorly rotated ears", "Postexertional malaise", "Postnatal growth retardation", "Postural instability", "Postural tremor", "Potter facies", "Preauricular skin tag", "Preaxial foot polydactyly", "Preaxial hand polydactyly", "Preaxial polydactyly", "Precocious atherosclerosis", "Predominantly lower limb lymphedema", "Prelingual sensorineural hearing impairment", "Premature adrenarche", "Premature arteriosclerosis", "Premature birth", "Premature coronary artery atherosclerosis", "Premature graying of hair", "Premature loss of primary teeth", "Premature loss of teeth", "Premature osteoarthritis", "Premature ovarian insufficiency", "Premature pubarche", "Premature rupture of membranes", "Premature skin wrinkling", "Premature thelarche", "Premature ventricular contraction", "Prematurely aged appearance", "Prenatal maternal abnormality", "Prenatal movement abnormality", "Primary adrenal insufficiency", "Primary amenorrhea", "Primary congenital glaucoma", "Primary gonadal insufficiency", "Primary hypercortisolism", "Primary hyperparathyroidism", "Primary microcephaly", "Primary peritoneal carcinoma", "Primitive neuroectodermal tumor", "Primitive reflex", "Productive cough", "Profound global developmental delay", "Profound hearing impairment", "Profound sensorineural hearing impairment", "Progeroid facial appearance", "Progressive", "Progressive cerebellar ataxia", "Progressive distal muscle weakness", "Progressive encephalopathy", "Progressive external ophthalmoplegia", "Progressive extrapyramidal movement disorder", "Progressive flexion contractures", "Progressive gait ataxia", "Progressive hearing impairment", "Progressive inability to walk", "Progressive leukoencephalopathy", "Progressive macrocephaly", "Progressive microcephaly", "Progressive muscle weakness", "Progressive neurologic deterioration", "Progressive night blindness", "Progressive peripheral neuropathy", "Progressive pes cavus", "Progressive proximal muscle weakness", "Progressive psychomotor deterioration", "Progressive pulmonary function impairment", "Progressive sensorineural hearing impairment", "Progressive spastic paraparesis", "Progressive spastic paraplegia", "Progressive spastic quadriplegia", "Progressive spasticity", "Progressive visual field defects", "Progressive visual loss", "Prolonged bleeding after dental extraction", "Prolonged bleeding after surgery", "Prolonged bleeding following circumcision", "Prolonged bleeding following procedure", "Prolonged bleeding time", "Prolonged neonatal jaundice", "Prolonged partial thromboplastin time", "Prolonged qtc interval", "Prominent antihelix", "Prominent antitragus", "Prominent digit pad", "Prominent ear helix", "Prominent eyelashes", "Prominent forehead", "Prominent metopic ridge", "Prominent nasal bridge", "Prominent nasal tip", "Prominent nasolabial fold", "Prominent nose", "Prominent occiput", "Prominent sternum", "Prominent superficial blood vessels", "Prominent supraorbital ridges", "Prominent umbilicus", "Prominent veins on trunk", "Proportionate short stature", "Proportionate tall stature", "Proptosis", "Prostate neoplasm", "Protein avoidance", "Protein losing enteropathy", "Protruding ear", "Protruding tongue", "Protrusio acetabuli", "Protuberant abdomen", "Proximal amyotrophy", "Proximal femoral epiphysiolysis", "Proximal femoral metaphyseal abnormality", "Proximal femoral metaphyseal irregularity", "Proximal muscle weakness", "Proximal muscle weakness in lower limbs", "Proximal muscle weakness in upper limbs", "Proximal renal tubular acidosis", "Proximal symphalangism", "Proximal tubulopathy", "Proximal upper limb amyotrophy", "Pruritus", "Pseudoarthrosis", "Pseudobulbar paralysis", "Pseudobulbar signs", "Pseudoepiphyses", "Pseudoepiphyses of hand bones", "Pseudoepiphyses of the metacarpals", "Pseudohypoaldosteronism", "Pseudohypoparathyroidism", "Psoriasiform dermatitis", "Psychogenic non epileptic seizure", "Psychomotor deterioration", "Psychomotor retardation", "Psychosis", "Psychotic episodes", "Psychotic mentation", "Pterygium", "Ptosis", "Puberty and gonadal disorders", "Pulmonary artery atresia", "Pulmonary artery dilatation", "Pulmonary artery hypoplasia", "Pulmonary artery stenosis", "Pulmonary carcinoid tumor", "Pulmonary cyst", "Pulmonary edema", "Pulmonary embolism", "Pulmonary fibrosis", "Pulmonary hemorrhage", "Pulmonary hypoplasia", "Pulmonary infiltrates", "Pulmonary insufficiency", "Pulmonary interstitial high resolution computed tomography abnormality", "Pulmonary venous hypertension", "Pulmonic stenosis", "Pulverulent cataract", "Punctate cataract", "Pure red cell aplasia", "Purpura", "Pustule", "Pyelonephritis", "Pyoderma gangrenosum", "Pyridoxine responsive sideroblastic anemia", "Quadriceps muscle weakness", "Radial bowing", "Radial deviation of the 2nd finger", "Radial deviation of the hand", "Radial deviation of the hand or of fingers of the hand", "Radioulnar dislocation", "Radioulnar synostosis", "Ragged red muscle fibers", "Rapidly progressive", "Raynaud phenomenon", "Reactive hypoglycemia", "Receptive language delay", "Rectal fistula", "Rectal prolapse", "Recurrent", "Recurrent abscess formation", "Recurrent acute respiratory tract infection", "Recurrent aspiration pneumonia", "Recurrent bacterial infections", "Recurrent bacterial skin infections", "Recurrent bronchitis", "Recurrent bronchopulmonary infections", "Recurrent corneal erosions", "Recurrent ear infections", "Recurrent fever", "Recurrent fractures", "Recurrent gastroenteritis", "Recurrent hand flapping", "Recurrent herpes", "Recurrent hypoglycemia", "Recurrent infection of the gastrointestinal tract", "Recurrent joint dislocation", "Recurrent lower respiratory tract infections", "Recurrent mycobacterial infections", "Recurrent opportunistic infections", "Recurrent otitis media", "Recurrent pancreatitis", "Recurrent paroxysmal headache", "Recurrent pharyngitis", "Recurrent pneumonia", "Recurrent respiratory infections", "Recurrent sinopulmonary infections", "Recurrent sinusitis", "Recurrent skin infections", "Recurrent staphylococcal infections", "Recurrent staphylococcus aureus infections", "Recurrent tonsillitis", "Recurrent upper and lower respiratory tract infections", "Recurrent urinary tract infections", "Recurrent viral infections", "Red eye", "Red green dyschromatopsia", "Red hair", "Reduced antigen specific t cell proliferation", "Reduced antithrombin iii activity", "Reduced brain n acetyl aspartate level by mrs", "Reduced c peptide level", "Reduced circulating prolactin concentration", "Reduced consciousness confusion", "Reduced delayed hypersensitivity", "Reduced factor viii activity", "Reduced factor xi activity", "Reduced factor xii activity", "Reduced factor xiii activity", "Reduced forced expiratory volume in one second", "Reduced forced vital capacity", "Reduced natural killer cell count", "Reduced pancreatic beta cells", "Reduced protein c activity", "Reduced protein s activity", "Reduced renal corticomedullary differentiation", "Reduced sperm motility", "Reduced subcutaneous adipose tissue", "Reduced systolic function", "Reduced tendon reflexes", "Reduced visual acuity", "Reduced vital capacity", "Reduction of neutrophil motility", "Redundant neck skin", "Redundant skin", "Refractory anemia", "Regional abnormality of skin", "Relative macrocephaly", "Renal agenesis", "Renal angiomyolipoma", "Renal cell carcinoma", "Renal cortical cysts", "Renal cortical microcysts", "Renal cyst", "Renal duplication", "Renal dysplasia", "Renal fanconi syndrome", "Renal fibrosis", "Renal hamartoma", "Renal hypoplasia", "Renal hypoplasia aplasia", "Renal insufficiency", "Renal magnesium wasting", "Renal malrotation", "Renal phosphate wasting", "Renal potassium wasting", "Renal salt wasting", "Renal tubular acidosis", "Renal tubular atrophy", "Renal tubular dysfunction", "Renal tubular epithelial necrosis", "Renovascular hypertension", "Repetitive compulsive behavior", "Respiratory alkalosis", "Respiratory arrest", "Respiratory distress", "Respiratory failure", "Respiratory failure requiring assisted ventilation", "Respiratory insufficiency", "Respiratory insufficiency due to defective ciliary clearance", "Respiratory paralysis", "Respiratory tract infection", "Response to drugs acting on neuromuscular transmission", "Resting tremor", "Restless legs", "Restlessness", "Restrictive behavior", "Restrictive cardiomyopathy", "Restrictive ventilatory defect", "Reticulated skin pigmentation", "Reticulocytopenia", "Reticulocytosis", "Retinal arteriolar tortuosity", "Retinal atrophy", "Retinal coloboma", "Retinal degeneration", "Retinal detachment", "Retinal dysplasia", "Retinal dystrophy", "Retinal fold", "Retinal hamartoma", "Retinal hemorrhage", "Retinal neovascularization", "Retinal perforation", "Retinal pigment epithelial atrophy", "Retinal pigment epithelial mottling", "Retinal telangiectasia", "Retinal thinning", "Retinal vascular tortuosity", "Retinopathy", "Retrocollis", "Retrognathia", "Rhabdomyolysis", "Rhabdomyosarcoma", "Rhegmatogenous retinal detachment", "Rheumatoid arthritis", "Rheumatoid factor positive", "Rhinitis", "Rhizomelia", "Rib fusion", "Rib segmentation abnormalities", "Rickets", "Ridged nail", "Rieger anomaly", "Right aortic arch with mirror image branching", "Right bundle branch block", "Right ventricular cardiomyopathy", "Right ventricular dilatation", "Right ventricular hypertrophy", "Rigidity", "Rimmed vacuoles", "Rod cone dystrophy", "Rotary nystagmus", "Round ear", "Round face", "Saccadic oscillation", "Saccadic smooth pursuit", "Sagittal craniosynostosis", "Sandal gap", "Sarcoma", "Scaling skin", "Scanning speech", "Scaphocephaly", "Scapular winging", "Scarring", "Scarring alopecia of scalp", "Schistocytosis", "Schizencephaly", "Schizophrenia", "Schwannoma", "Scleral staphyloma", "Sclerocornea", "Scleroderma", "Sclerosis of hand bone", "Sclerosis of skull base", "Scotoma", "Scrotal hypoplasia", "Sea blue histiocytosis", "Seborrheic dermatitis", "Second degree atrioventricular block", "Secondary amenorrhea", "Secondary growth hormone deficiency", "Secondary microcephaly", "Secretory diarrhea", "Secundum atrial septal defect", "Segmental peripheral demyelination remyelination", "Selective tooth agenesis", "Self injurious behavior", "Self mutilation", "Semilobar holoprosencephaly", "Senile plaques", "Sensorimotor neuropathy", "Sensory ataxia", "Sensory axonal neuropathy", "Sensory neuropathy", "Sepsis", "Septate vagina", "Septic arthritis", "Septo optic dysplasia", "Serositis", "Severe combined immunodeficiency", "Severe cytomegalovirus infection", "Severe demyelination of the white matter", "Severe expressive language delay", "Severe failure to thrive", "Severe global developmental delay", "Severe hearing impairment", "Severe infection", "Severe intrauterine growth retardation", "Severe lactic acidosis", "Severe muscular hypotonia", "Severe photosensitivity", "Severe postnatal growth retardation", "Severe short limb dwarfism", "Severe short stature", "Severe varicella zoster infection", "Severe viral infection", "Severely reduced visual acuity", "Shagreen patch", "Shallow anterior chamber", "Shallow orbits", "Shawl scrotum", "Shield chest", "Shock", "Short 1st metacarpal", "Short attention span", "Short chin", "Short clavicles", "Short digit", "Short face", "Short femur", "Short foot", "Short fourth metatarsal", "Short lingual frenulum", "Short long bone", "Short lower limbs", "Short middle phalanx of finger", "Short nail", "Short nose", "Short palm", "Short palpebral fissure", "Short phalanx of the thumb", "Short philtrum", "Short proximal phalanx of finger", "Short ribs", "Short stepped shuffling gait", "Short sternum", "Short thorax", "Short thumb", "Short tibia", "Short umbilical cord", "Short upper lip", "Shortened pr interval", "Shortened qt interval", "Shortening of all distal phalanges of the fingers", "Shortening of all middle phalanges of the fingers", "Shoulder dislocation", "Shoulder girdle muscle atrophy", "Shoulder girdle muscle weakness", "Shoulder pain", "Shuffling gait", "Shyness", "Sideroblastic anemia", "Simple ear", "Simple febrile seizure", "Simplified gyral pattern", "Single fiber emg abnormality", "Single naris", "Single transverse palmar crease", "Single ventricle", "Sinus bradycardia", "Sinus tachycardia", "Sirenomelia", "Skeletal dysplasia", "Skeletal muscle atrophy", "Skeletal muscle hypertrophy", "Skeletal myopathy", "Skin appendage neoplasm", "Skin dimple", "Skin erosion", "Skin nodule", "Skin picking", "Skin pit", "Skin plaque", "Skin rash", "Skin tags", "Skin ulcer", "Skin vesicle", "Skull asymmetry", "Slanting of the palpebral fissure", "Sleep apnea", "Sleep disturbance", "Sleep wake cycle disturbance", "Slender build", "Slender finger", "Slender long bone", "Sloping forehead", "Slow decrease in visual acuity", "Slow pupillary light response", "Slow saccadic eye movements", "Slowly progressive", "Slurred speech", "Small anterior fontanelle", "Small basal ganglia", "Small cerebral cortex", "Small earlobe", "Small epiphyses", "Small face", "Small for gestational age", "Small hand", "Small intestinal dysmotility", "Small nail", "Small placenta", "Smooth muscle antibody positivity", "Smooth philtrum", "Snoring", "Social and occupational deterioration", "Soft doughy skin", "Soft skin", "Soft tissue sarcoma", "Solitary median maxillary central incisor", "Somatic mosaicism", "Somatic mutation", "Somatic sensory dysfunction", "Sound sensitivity", "Sparse and thin eyebrow", "Sparse body hair", "Sparse eyebrow", "Sparse eyelashes", "Sparse hair", "Sparse lateral eyebrow", "Sparse or absent eyelashes", "Sparse scalp hair", "Spastic ataxia", "Spastic diplegia", "Spastic dysarthria", "Spastic gait", "Spastic hyperactive bladder", "Spastic paraparesis", "Spastic paraparetic gait", "Spastic paraplegia", "Spastic tetraparesis", "Spastic tetraplegia", "Spasticity", "Specific learning disability", "Speech apraxia", "Speech articulation difficulties", "Spina bifida", "Spina bifida occulta", "Spinal canal stenosis", "Spinal cord compression", "Spinal cord lesion", "Spinal cord tumor", "Spinal muscular atrophy", "Spinal rigidity", "Splanchnic vein thrombosis", "Splenomegaly", "Split nail", "Spoken word recognition deficit", "Spondyloepimetaphyseal dysplasia", "Spondyloepiphyseal dysplasia", "Spondylolisthesis", "Spondylolysis", "Spontaneous abortion", "Spontaneous hemolytic crises", "Spontaneous pain sensation", "Spontaneous recurrent epistaxis", "Sporadic", "Spotty hyperpigmentation", "Spotty hypopigmentation", "Sprengel anomaly", "Squamous cell carcinoma", "Squamous cell carcinoma of the skin", "Square face", "Squared iliac bones", "Stage 5 chronic kidney disease", "Staring gaze", "Status epilepticus", "Status epilepticus with prominent motor symptoms", "Stenosis of the external auditory canal", "Steppage gait", "Stereotypical hand wringing", "Stereotypy", "Steroid resistant nephrotic syndrome", "Stiff skin", "Stillbirth", "Stomach cancer", "Stomatitis", "Stomatocytosis", "Stooped posture", "Streak ovary", "Striae distensae", "Stridor", "Stroke", "Stroke like episode", "Stuttering", "Subacute progressive viral hepatitis", "Subarachnoid hemorrhage", "Subcapsular cataract", "Subcortical band heterotopia", "Subcortical cerebral atrophy", "Subcortical heterotopia", "Subcutaneous hemorrhage", "Subcutaneous nodule", "Subdural hemorrhage", "Subependymal cysts", "Subglottic stenosis", "Submucous cleft of soft and hard palate", "Submucous cleft soft palate", "Subretinal fluid", "Subsarcolemmal accumulations of abnormally shaped mitochondria", "Substantia nigra gliosis", "Subvalvular aortic stenosis", "Sudden death", "Sudden episodic apnea", "Sudden loss of visual acuity", "Suicidal ideation", "Sunken cheeks", "Supernumerary bones of the axial skeleton", "Supernumerary nipple", "Supernumerary spleens", "Supernumerary tooth", "Supranuclear gaze palsy", "Supranuclear ophthalmoplegia", "Supravalvular aortic stenosis", "Supraventricular arrhythmia", "Supraventricular tachycardia", "Symphalangism affecting the phalanges of the hand", "Symphalangism of middle phalanx of finger", "Symptomatic seizures", "Syncope", "Syndactyly", "Synostosis involving bones of the hand", "Synostosis involving bones of the lower limbs", "Synostosis involving bones of the upper limbs", "Synostosis involving digits", "Synostosis of carpal bones", "Synostosis of carpals tarsals", "Synostosis of joints", "Synostosis of metacarpals metatarsals", "Synovitis", "Syringomyelia", "Systemic lupus erythematosus", "T cell lymphoma", "T lymphocytopenia", "Tachycardia", "Tachypnea", "Talipes calcaneovalgus", "Talipes equinovalgus", "Talipes equinovarus", "Talipes valgus", "Tall stature", "Tapered distal phalanges of finger", "Tapered finger", "Tarsal synostosis", "Telangiectasia", "Telangiectasia of the skin", "Telecanthus", "Temperature instability", "Temporal cortical atrophy", "Temporal optic disc pallor", "Temporal pattern", "Tented upper lip vermilion", "Teratoma", "Testicular adrenal rest tumor", "Testicular atrophy", "Testicular dysgenesis", "Tetany", "Tetralogy of fallot", "Tetraparesis", "Tetraplegia", "Tetraplegia tetraparesis", "Thenar muscle atrophy", "Thick cerebral cortex", "Thick corpus callosum", "Thick eyebrow", "Thick hair", "Thick lower lip vermilion", "Thick nasal alae", "Thick upper lip vermilion", "Thick vermilion border", "Thickened calvaria", "Thickened cortex of long bones", "Thickened ears", "Thickened helices", "Thickened nuchal skin fold", "Thickened ribs", "Thickened skin", "Thin bony cortex", "Thin clavicles", "Thin eyebrow", "Thin lower lip vermilion", "Thin nail", "Thin ribs", "Thin skin", "Thin upper lip vermilion", "Thin vermilion border", "Thinning of descemet membrane", "Third degree atrioventricular block", "Thoracic aortic aneurysm", "Thoracic hypoplasia", "Thoracic kyphoscoliosis", "Thoracic kyphosis", "Thoracic scoliosis", "Thoracolumbar kyphoscoliosis", "Thoracolumbar kyphosis", "Thoracolumbar scoliosis", "Thrombocytosis", "Thromboembolism", "Thyroid adenoma", "Thyroid carcinoma", "Thyroiditis", "Tibial bowing", "Tibial torsion", "Tics", "Tiger tail banding", "Tinnitus", "Tip toe gait", "Tissue ischemia", "Titubation", "Toe clinodactyly", "Toe syndactyly", "Toe walking", "Toenail dysplasia", "Tongue atrophy", "Tongue fasciculations", "Tongue nodules", "Tongue thrusting", "Tonic seizure", "Tooth malposition", "Torsion dystonia", "Total anomalous pulmonary venous return", "Toxemia of pregnancy", "Tracheal stenosis", "Tracheobronchomalacia", "Tracheoesophageal fistula", "Tracheomalacia", "Tractional retinal detachment", "Transient global amnesia", "Transient ischemic attack", "Transient neonatal diabetes mellitus", "Transient neutropenia", "Transposition of the great arteries", "Tremor", "Tremor by anatomical site", "Triangular face", "Triangular mouth", "Triangular shaped phalanges of the hand", "Triceps weakness", "Trichorrhexis nodosa", "Tricuspid atresia", "Tricuspid stenosis", "Tricuspid valve prolapse", "Trigonocephaly", "Triphalangeal thumb", "Trismus", "Tritanomaly", "Trophic changes related to pain", "Truncal ataxia", "Truncal obesity", "Truncal titubation", "Truncus arteriosus", "Tube feeding", "Tubulointerstitial nephritis", "Turricephaly", "Type 1 fibers relatively smaller than type 2 fibers", "Type 1 muscle fiber atrophy", "Type 2 muscle fiber atrophy", "Type 2 muscle fiber predominance", "Type i diabetes mellitus", "Type i transferrin isoform profile", "Type ii diabetes mellitus", "Type ii lissencephaly", "Type ii transferrin isoform profile", "Typical absence seizure", "U shaped upper lip vermilion", "Ulnar bowing", "Ulnar claw", "Ulnar deviation of finger", "Ulnar deviation of the 2nd finger", "Ulnar deviation of the hand", "Ulnar deviation of the hand or of fingers of the hand", "Ulnar deviation of the wrist", "Uncombable hair", "Unconjugated hyperbilirubinemia", "Underdeveloped nasal alae", "Underdeveloped supraorbital ridges", "Underdeveloped tragus", "Undetectable electroretinogram", "Undetectable light and dark adapted electroretinogram", "Undetectable visual evoked potentials", "Unexplained fevers", "Unilateral primary pulmonary dysgenesis", "Unilateral ptosis", "Unilateral renal agenesis", "Unsteady gait", "Unusual fungal infection", "Unusual infection", "Unusual infection by anatomical site", "Unusual skin infection", "Upgaze palsy", "Uplifted earlobe", "Upper airway obstruction", "Upper extremity joint dislocation", "Upper eyelid coloboma", "Upper limb amyotrophy", "Upper limb asymmetry", "Upper limb hypertonia", "Upper limb muscle weakness", "Upper limb pain", "Upper limb postural tremor", "Upper limb spasticity", "Upper limb undergrowth", "Upper motor neuron dysfunction", "Upslanted palpebral fissure", "Ureteral duplication", "Ureteral obstruction", "Ureteral stenosis", "Ureterocele", "Ureteropelvic junction obstruction", "Urethral obstruction", "Urethral stenosis", "Urethral stricture", "Urethral valve", "Uric acid nephrolithiasis", "Urinary bladder sphincter dysfunction", "Urinary glycosaminoglycan excretion", "Urinary incontinence", "Urinary retention", "Urinary tract neoplasm", "Urinary urgency", "Urogenital fistula", "Urogenital sinus anomaly", "Urticaria", "Uterine prolapse", "Uveal melanoma", "Uveitis", "Vacuolated lymphocytes", "Vaginal atresia", "Vaginal fistula", "Vaginal neoplasm", "Variable expressivity", "Varicose veins", "Vascular calcification", "Vascular dilatation", "Vascular neoplasm", "Vascular skin abnormality", "Vascular tortuosity", "Vasculitis", "Vegetative state", "Vein of galen aneurysmal malformation", "Velopharyngeal insufficiency", "Venous insufficiency", "Venous malformation", "Venous thrombosis", "Ventilator dependence with inability to wean", "Ventricular arrhythmia", "Ventricular escape rhythm", "Ventricular fibrillation", "Ventricular hypertrophy", "Ventricular preexcitation", "Ventricular septal hypertrophy", "Ventricular tachycardia", "Ventriculomegaly", "Verrucae", "Vertebral arch anomaly", "Vertebral clefting", "Vertebral compression fracture", "Vertebral fusion", "Vertebral hypoplasia", "Vertebral segmentation defect", "Vertebral wedging", "Vertical nystagmus", "Vertical supranuclear gaze palsy", "Vertigo", "Very long chain fatty acid accumulation", "Vestibular dysfunction", "Viral encephalitis", "Viral hepatitis", "Viral infection induced rhabdomyolysis", "Visceral angiomatosis", "Visual acuity test abnormality", "Visual field defect", "Visual fixation instability", "Visual hallucinations", "Visual impairment", "Visual loss", "Vitamin b12 deficiency", "Vitiligo", "Vitreoretinopathy", "Vitreous floaters", "Vitreous hemorrhage", "Vitritis", "Vocal cord paralysis", "Vocal cord paresis", "Volvulus", "Vomiting", "Waddling gait", "Weak cry", "Weak voice", "Weakness due to upper motor neuron dysfunction", "Weakness of facial musculature", "Weakness of long finger extensor muscles", "Weakness of muscles of respiration", "Weakness of the intrinsic hand muscles", "Webbed neck", "Weight loss", "Wheezing", "White forelock", "White hair", "Wide anterior fontanel", "Wide cranial sutures", "Wide intermamillary distance", "Wide mouth", "Wide nasal bridge", "Wide nasal ridge", "Wide nose", "Widely patent fontanelles and sutures", "Widely spaced incisors", "Widely spaced teeth", "Widened cerebral subarachnoid space", "Widened subarachnoid space", "Widow s peak", "Woolly hair", "Wormian bones", "Wrist flexion contracture", "Writer s cramp", "X linked dominant inheritance", "X linked recessive inheritance", "Xanthomatosis", "Xerostomia", "Yellow white lesions of the retina", "Young adult onset", "Zonular cataract"], "available_proteins": ["AAAS", "AARS", "AARS2", "AASS", "ABCB1", "ABCB7", "ABCD3", "ABHD12", "ACACA", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACO2", "ACOX1", "ACP2", "ACSF3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ADAM17", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADPRHL2", "ADSL", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKT2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ANAPC1", "ANK3", "ANKLE2", "ANKRD17", "ANLN", "ANXA11", "AP1B1", "AP2M1", "AP3B1", "AP3D1", "APOL2", "APP", "APRT", "ARCN1", "ARHGDIA", "ARHGEF2", "ARID1A", "ARL2", "ARL3", "ARL6IP1", "ARPC1B", "ASAH1", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD3A", "ATIC", "ATP1A1", "ATP2A2", "ATP2B4", "ATP5A1", "ATP6AP1", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATXN10", "B4GAT1", "BANF1", "BAZ1B", "BCAP31", "BCAT2", "BLM", "BLVRA", "BMS1", "BPTF", "BRCA1", "BUB1B", "BUB3", "BUD23", "C19orf70", "C1QBP", "CAD", "CALD1", "CALR", "CAMK2G", "CAPN1", "CARS", "CAST", "CCDC47", "CCT5", "CD2AP", "CD3EAP", "CDC42", "CDC73", "CDK4", "CDK5", "CDK6", "CFL2", "CHAMP1", "CHD4", "CHORDC1", "CHST14", "CISD2", "CIZ1", "CLASP1", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNNM4", "CNOT1", "CNOT3", "CNP", "COA3", "COA7", "COG7", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COX2", "COX4I1", "COX5A", "CPNE1", "CPOX", "CPSF1", "CPT2", "CRKL", "CRTAP", "CSNK2B", "CSTB", "CTBP1", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTSA", "CUL3", "CUL4B", "CWF19L1", "CYB5R3", "CYC1", "DARS", "DARS2", "DCPS", "DCTN1", "DCTN4", "DCXR", "DDB1", "DDOST", "DDRGK1", "DDX3X", "DDX41", "DDX6", "DGCR8", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHX16", "DHX30", "DHX37", "DHX38", "DIABLO", "DIAPH1", "DIAPH3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPF2", "DPM1", "DPP9", "DSG2", "DSP", "DST", "DYNC1H1", "DYNC1I2", "DYNLL1", "ECE1", "ECHS1", "EDC3", "EEF1A2", "EEF2", "EFL1", "EFTUD2", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF3F", "EIF4A3", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELP1", "ELP2", "EMC1", "EMD", "EMG1", "EPB41", "EPRS", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERLIN2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXOC2", "EXOC7", "EXOSC1", "EXOSC3", "EZR", "FAH", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FDFT1", "FDPS", "FECH", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FOXC1", "FRG1", "FSCN1", "FTO", "FUS", "FXR1", "G6PD", "GAA", "GALK1", "GALNT2", "GANAB", "GAPVD1", "GARS", "GATB", "GBA", "GCDH", "GDI1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGCX", "GIGYF2", "GINS1", "GLA", "GLB1", "GLDC", "GLE1", "GLMN", "GLRX5", "GLS", "GLUD1", "GM2A", "GMPPA", "GNAI2", "GNAI3", "GNPAT", "GNS", "GOT2", "GPAA1", "GPD2", "GPI", "GPRASP2", "GRHPR", "GSR", "GSS", "GSTM3", "GTF2I", "GTPBP3", "GUSB", "GYS1", "H2AFY", "HADH", "HADHA", "HADHB", "HAX1", "HCCS", "HCFC1", "HELLS", "HERC2", "HEXA", "HEXB", "HIBCH", "HIST1H1E", "HK1", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HMGA1", "HMGB3", "HMGCL", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HPRT1", "HPS6", "HSD17B10", "HSD17B4", "HSPA9", "HSPB1", "HSPD1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFT27", "IGBP1", "IGF2R", "INF2", "IRS4", "ITCH", "ITPA", "IVD", "JUP", "KARS", "KDM1A", "KDM3B", "KDSR", "KEAP1", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF4A", "KIFBP", "KLC2", "KMT2A", "L2HGDH", "LAMTOR2", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LEMD3", "LETM1", "LIPA", "LLGL1", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LONP1", "LRBA", "LRPAP1", "LRPPRC", "LSS", "MACF1", "MAGED2", "MAGT1", "MAP1B", "MAP2K1", "MAPRE2", "MARS", "MAT2A", "MATR3", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "MECP2", "MFN2", "MIA3", "MICU1", "MID1", "MIF", "MINPP1", "MIPEP", "MMAB", "MOGS", "MPI", "MRE11", "MRPL12", "MRPL3", "MRPL44", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS34", "MRPS35", "MRPS7", "MSH2", "MSH3", "MSH6", "MSN", "MTAP", "MTCH1", "MTHFD1", "MTOR", "MTPAP", "MTR", "MTX2", "MYH14", "MYH9", "MYO6", "NAA15", "NADK2", "NAGLU", "NANS", "NARS", "NAXE", "NCAPD2", "NCAPH", "NCSTN", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFB11", "NDUFB3", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NEDD4L", "NEFL", "NEK9", "NEMF", "NEU1", "NHLRC2", "NHP2", "NIPBL", "NNT", "NONO", "NOP56", "NPC1", "NPC2", "NPM1", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NT5C2", "NUMA1", "NUP107", "NUP133", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP37", "NUP62", "NUP85", "NUP88", "NUP93", "OAT", "OCLN", "OGDH", "OGT", "OPA1", "OPA3", "P3H1", "P4HA2", "P4HB", "PABPN1", "PAFAH1B1", "PALLD", "PARK7", "PARN", "PBRM1", "PC", "PCCA", "PCCB", "PCNA", "PDCD6", "PDHA1", "PDHB", "PDHX", "PDK3", "PEPD", "PEX14", "PFKM", "PFN1", "PGK1", "PGM1", "PGM3", "PHB", "PHF6", "PHGDH", "PHIP", "PICALM", "PIGS", "PIGT", "PISD", "PITRM1", "PLAA", "PLD3", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLD1", "POLE", 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sha256:f41b701482db610b9dc0d56feabb4ffaed029ecedc430e2662026c4d490a4d7c +size 136472 diff --git a/msigdb_kegg/consensus.joblib b/msigdb_kegg/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..3524c8878e72f9196f2e15d50ef67b048ede0b1c --- /dev/null +++ b/msigdb_kegg/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:708af61f3af98d308360dd320fb1518109140c83cf684f909b91d3ca99e5df78 +size 64661 diff --git a/msigdb_kegg/df_merge.tsv b/msigdb_kegg/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..e5a34519aeb18a6ead05ba8aa153801387ad7530 --- /dev/null +++ b/msigdb_kegg/df_merge.tsv @@ -0,0 +1,12 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Lysosome 19 40 3.320683305666205 0.0008979736902952 21.740291262135923 48.609223300970875 0.8281821627988494 0.1302152537326229 7.142313942893836 4.247239237941681 3.086075071395461 0.2389623217115766 1.0 0.0818055658937606 4.9146476127391394e-06 1.7787636833476229e-12 1.821524931049836e-10 +Sphingolipid metabolism 6 10 2.7232041302351537 0.0064652096650719 5.672330097087379 11.759708737864075 0.9805985471070467 0.1821702203806468 2.452838935293596 1.3449033287601222 1.7625559835482287 0.2542774311591588 1.0 0.0063255491406275 0.0017488676437986 1.4492280010576038e-06 0.0001279618339571 +Parkinsons disease 11 44 2.720762127627512 0.0065131610596675 16.90776699029126 54.04126213592233 1.0315348591123816 0.3152611195514452 7.595108151251147 4.223805209268991 1.8494970521239744 0.3626807692210581 1.0 0.0014681613257241 0.0032220444708257 6.51109102422212e-06 7.299059024329607e-06 +Oxidative phosphorylation 13 48 2.5289292216942467 0.0114411096788056 18.79854368932039 59.0752427184466 1.0149760730411637 0.3252836463038503 7.263801581344288 4.652138947381941 1.8018345229041028 0.3643612228552857 1.0 0.3926779415133941 0.0177897684291767 1.5943182612816704e-07 7.299059024329607e-06 +Cardiac muscle contraction 6 17 2.424528015894797 0.0153283005706059 7.728155339805825 19.856796116504853 1.0644813600437804 0.240240383706381 3.4195161605095614 1.765741250102918 1.6465694074711887 0.3002212677564749 1.0 0.1952735388158895 0.3559802976275766 9.063996119237736e-05 0.0052617874550274 +Gap junction 3 11 2.215849451950786 0.0267018143649895 6.849514563106796 16.725728155339805 0.1092386662992923 0.5937456832302471 4.017760903410304 2.3953875993966403 0.9524162344483764 0.3203538229624096 1.0 0.2552681350600493 0.0028574061260132 0.0593060830293246 0.0716644021219785 +Calcium signaling pathway 2 14 2.2042092892954672 0.0275096287908995 5.735436893203883 16.946601941747574 1.0005800740695592 0.3113014190776675 2.984654368989517 2.3866666657890168 1.2450167285670062 0.3187454651207294 1.0 0.003696507335194 0.0251363642152908 0.2067196289529824 0.2015721806705039 +Huntingtons disease 11 62 2.189853708138703 0.0285348481536265 19.631067961165048 76.91504854368932 0.635715043905642 0.4301008974270168 9.08454389027927 5.4148363920790175 1.5734816663041495 0.3870978376334237 1.0 0.0055731314175051 0.0148644194292276 0.0002537727744554 0.0002770502147712 +Other glycan degradation 3 6 2.174425552755473 0.0296731907972898 3.966019417475728 7.12378640776699 0.0449593300314452 0.158186848086018 1.7909726921672984 0.8075596903062239 1.9584092358200416 0.2320333335657103 1.0 0.0652597674910206 0.1277572387780678 0.0002735626391213 0.0035872092776678 +Pathogenic escherichia coli infection 3 20 2.122973528363381 0.0337560701685999 8.04368932038835 23.04126213592233 -0.1828642907559088 0.5748742925026463 4.5754764175075255 2.330828920267767 0.9569379411043492 0.3191018272971252 1.0 0.1952735388158895 0.0009182879541791 0.0227330174276438 0.0633296250195141 +Porphyrin and chlorophyll metabolism 1 10 1.9885645812464567 0.0467492840772276 3.728155339805826 13.315533980582524 1.2215621624941897 0.2689555702886888 1.770547470360957 1.4201912411596824 1.0389071586082248 0.2908939383930566 0.0039194514344562 0.0040679264544396 0.0158256043387446 0.0828772873031817 0.068509275445109 diff --git a/msigdb_kegg/metrics.json b/msigdb_kegg/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..eb5d230b521cead1b1a5d117af5e88ae62efb33b --- /dev/null +++ b/msigdb_kegg/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2454, + "annotations_size": 178, + "title": "Average number of proteins per term", + "value": 12.831460674157304 +} \ No newline at end of file diff --git a/msigdb_kegg/paths.json b/msigdb_kegg/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..2e9d9fb593f3f69be01c5376d862f23d4a58475e --- /dev/null +++ b/msigdb_kegg/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_kegg/fragment/C340/C340_val_log2fc"} \ No newline at end of file diff --git a/msigdb_kegg/result.tsv b/msigdb_kegg/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..2364aae273d3b579b4c952ee4c6373c355610ace --- /dev/null +++ b/msigdb_kegg/result.tsv @@ -0,0 +1,58 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Lysosome 0.6670921813493906 3.320683305666205 0.0008979736902952 0.147780473912793 0.1598393168725468 40 P06280,P50897,P16278,Q15904,P61421,O75503,Q13510,Q99519,Q14108,P61916,P10619,Q93050,P17900,P11279,P04062,P11117,Q9Y487,P10253,O43681 19 +Sphingolipid metabolism 0.8641477591086919 2.7232041302351537 0.0064652096650719 0.6847986184804005 0.2769712032611243 10 Q06136,P06280,P04062,P16278,Q13510,O43681 6 +Parkinsons disease 0.5682435878762925 2.7207621276275114 0.0065131610596675 0.6874949454817106 0.2769712032611243 44 P45880,O75306,Q9UDW1,P31930,Q08752,P00403,P14406,P21796,P20674,O43676,O14949 11 +Oxidative phosphorylation 0.5260730415363883 2.5289292216942467 0.0114411096788056 0.871040536687913 0.334672697510458 48 P61421,Q9Y487,O75306,Q9UDW1,P31930,O75964,P00403,P14406,P20674,O43676,Q93050,O14949,Q15904 13 +Cardiac muscle contraction 0.6722113860611538 2.424528015894797 0.0153283005706059 0.936044313383744 0.334672697510458 17 Q9UDW1,P31930,P00403,P14406,P20674,O14949 6 +Gap junction 0.7307840959244845 2.215849451950786 0.0267018143649895 0.9919132753718406 0.3772734258512561 11 Q9BUF5,P07437,P68371 3 +Calcium signaling pathway 0.6713264518897678 2.2042092892954672 0.0275096287908995 0.9930243420109868 0.3772734258512561 14 P21796,Q08752 2 +Huntingtons disease 0.4546231183942142 2.189853708138703 0.0285348481536265 0.9942184234040264 0.3772734258512561 62 P45880,O75306,Q9UDW1,P31930,Q08752,P00403,P14406,P21796,P20674,O43676,O14949 11 +Other glycan degradation 0.8801358977197136 2.174425552755473 0.0296731907972898 0.9953074440175316 0.3772734258512561 6 Q9BTY2,P04062,P16278 3 +Pathogenic escherichia coli infection 0.6014110631618745 2.122973528363381 0.0337560701685999 0.9977846283685556 0.4005720326673859 20 Q9BUF5,P07437,P68371 3 +Renin angiotensin system 0.906117138439243 2.057141817648767 0.0396725862270415 0.9992575963086046 0.4413575217758367 4 Q9UIQ6 1 +Porphyrin and chlorophyll metabolism 0.7049830293818287 1.9885645812464572 0.0467492840772276 0.9998009918142344 0.4458112508754734 10 P30519 1 +Pantothenate and coa biosynthesis 0.880505709624792 1.7751174545143236 0.0758784955278484 0.9999992060820668 0.5627655084982092 2 O15382 1 +Riboflavin metabolism 0.7808534612563355 1.674335395603369 0.0940647018425333 0.9999999769166782 0.5710801421005153 5 Q8NFF5,Q9Y217,P11117 3 +Steroid hormone biosynthesis 0.8425774877650911 1.613335403759916 0.1066716587967702 0.9999999980946358 0.5710801421005153 2 Q53GQ0 1 +Glycosaminoglycan degradation 0.7422625943155745 1.60435619161721 0.1086355616143306 0.999999998712213 0.5710801421005153 6 P15586,P54802,P16278,P08236 4 +Proteasome 0.4530985412784207 1.5569645561942227 0.1194789007859664 0.9999999998542264 0.5710801421005153 35 P28070,P28072,P20618,P49721,P60900,Q99436 6 +Galactose metabolism 0.5613582187266741 1.5375364024138842 0.12416200782642 0.99999999994358 0.5710801421005153 13 P10253,P16278 2 +Alzheimers disease 0.4202981465830543 1.50406638461175 0.1325642746440036 0.9999999999898552 0.5710801421005153 46 O75306,Q9UDW1,P05067,P31930,P00403,P14406,P20674,O43676,O14949 9 +Folate biosynthesis 0.8800489596083266 1.4951729747528073 0.134869304682637 0.9999999999936824 0.5710801421005153 3 P00374,P35270 2 +Steroid biosynthesis 0.6291967664365083 1.494910812448633 0.1349377200393395 0.9999999999937708 0.5710801421005153 8 Q9UBM7,P48449,Q16850 3 +Biosynthesis of unsaturated fatty acids 0.6208870651582963 1.4547949060328482 0.1457260488489813 0.9999999999993328 0.5813169431433377 8 P40939,Q15067 2 +Glutathione metabolism 0.5064424167818204 1.450345673226359 0.146962148547473 0.9999999999994844 0.5813169431433377 18 P48735,O75874 2 +Vibrio cholerae infection 0.4972573743023968 1.390941087671329 0.1642432920381709 0.9999999999999865 0.5979479984430189 18 Q93050,Q9Y487,P24390,Q15904 4 +Snare interactions in vesicular transport 0.5951795140261619 1.3300406699116325 0.1835048717636325 0.9999999999999998 0.6281512918062805 8 Q9UNK0,P51809,O95721 3 +Epithelial cell signaling in helicobacter pylori infection 0.4915433672131879 1.2216170633234136 0.2218524728616597 1.0 0.6808575891271627 15 Q93050,Q9Y487,Q15904 3 +O glycan biosynthesis 0.7915261462618517 1.1520335231951355 0.2493072980589852 1.0 0.7274868697458913 3 Q10472 1 +Metabolism of xenobiotics by cytochrome p450 0.5524459311975334 1.1211831791961342 0.262209898163523 1.0 0.7327343806933841 8 P07099 1 +Tryptophan metabolism 0.4890215039004161 1.120870227519666 0.262343105522469 1.0 0.7327343806933841 13 P51648,Q16836,P40939,P30837 4 +Nicotinate and nicotinamide metabolism 0.6469737361351089 1.1086723746172975 0.267571543511629 1.0 0.7327343806933841 5 P43490 1 +Fatty acid metabolism 0.4054450824497288 0.9075844129592472 0.3640978325623392 1.0 0.874237669240417 23 P30837,P23786,Q16836,P16219,P40939 5 +Abc transporters 0.5640427011505411 0.8392374562165842 0.4013360722994201 1.0 0.8819484057937875 6 P08183 1 +Citrate cycle tca cycle 0.3903007281581258 0.8272132540509199 0.4081162005997671 1.0 0.8859107769116896 24 P48735 1 +Ascorbate and aldarate metabolism 0.5443942225043765 0.7565726110095178 0.4493059554089327 1.0 0.9521007150332146 6 P51648,O60701,P30837 3 +Mismatch repair 0.4064488756673962 0.7359059766600925 0.4617879197806482 1.0 0.952611341617326 16 P41440,Q9UQ84,P35250 3 +Butanoate metabolism 0.3994839686315902 0.7309645203599231 0.4648008244826795 1.0 0.952611341617326 17 P30837,Q16836,P16219,P40939,P51648 5 +Limonene and pinene degradation 0.4890422910134341 0.6613806164104494 0.508368253490715 1.0 0.9598991867102254 7 P51648,P40939,P30837 3 +Nucleotide excision repair 0.3762202499227419 0.59684982327352 0.5506076501262511 1.0 0.9698368245864668 18 P18074,P41440,P35250 3 +Glycerolipid metabolism 0.4288522735545346 0.5956557788567758 0.5514052056072534 1.0 0.9698368245864668 10 P51648,P06280,P30837 3 +Glycerophospholipid metabolism 0.4108094502856747 0.5083725582045914 0.6111920938734148 1.0 0.9987610029030124 10 Q9UG56 1 +Lysine degradation 0.3476067795075591 0.4281363508447568 0.6685518528346814 1.0 0.9987610029030124 19 Q9NRN7,P30837,O96028,Q16836,P40939,P51648 6 +Fc epsilon ri signaling pathway 0.4955424732054682 0.417706367390858 0.6761618162926331 1.0 0.9987610029030124 4 P31751 1 +Vegf signaling pathway 0.4330445388428362 0.3269542501163779 0.7437024882305436 1.0 0.9987610029030124 6 P04792 1 +Apoptosis 0.33597415489897 0.2319544027127207 0.8165734293226272 1.0 1.0 12 P31751,O95831 2 +Jak stat signaling pathway 0.480259426496869 0.1583383856576241 0.8741901622602115 1.0 1.0 3 P31751 1 +Long term depression 0.3870960054523105 0.1553976822523805 0.8765078112654694 1.0 1.0 5 P04899,P08754,P30153 3 +Notch signaling pathway 0.3527962220953703 0.1474241096926624 0.8827972766499066 1.0 1.0 7 Q92542,Q13363,Q13573 3 +Histidine metabolism 0.3678516497157984 0.1341087282617938 0.8933165978391486 1.0 1.0 6 P51648,P30837 2 +Rna degradation 0.2847139360720335 0.119331504046559 0.9050127251979644 1.0 1.0 30 Q9H9A5,Q15024,Q9GZS3,Q92600,Q9Y2L1,Q9UIV1,Q9NQT5,Q96C86,P62312,Q9Y3B2 10 +Valine leucine and isoleucine degradation 0.2825847241693587 0.0983119722199328 0.9216845717799664 1.0 1.0 27 Q16836,O15382,P40939,P30837 4 +Dilated cardiomyopathy 0.3337418300653614 0.0594993543614781 0.9525543797127748 1.0 1.0 6 P05556,P50402,P16615,P02545,P17612 5 +Drug metabolism cytochrome p450 0.3112404737483291 0.0442980768021206 0.9646668046610782 1.0 1.0 7 O14880 1 +Beta alanine metabolism 0.2934193424773168 0.0439184002346205 0.9649694481852876 1.0 1.0 10 P51648,P40939,P30837 3 +Pentose and glucuronate interconversions 0.3242026236650008 0.0362412701673386 0.971089978754661 1.0 1.0 5 O60701 1 +Primary immunodeficiency 0.3769889840881228 0.0328055371498724 0.9738296625838856 1.0 1.0 3 P13051,Q03519 2 +Acute myeloid leukemia 0.3088170968257927 0.0175576264983092 0.9859917606169252 1.0 1.0 6 P31751 1 +Prion diseases 0.257037943696446 0.0002248793117246 0.9998205722706432 1.0 1.0 3 P31948,P17612 2 diff --git a/msigdb_kegg/selections.json b/msigdb_kegg/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..84849fc0e2fc1cca786c6cb99ac03b9429ddfd82 --- /dev/null +++ b/msigdb_kegg/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Abc transporters", "Acute myeloid leukemia", "Adherens junction", "Adipocytokine signaling pathway", "Alanine aspartate and glutamate metabolism", "Aldosterone regulated sodium reabsorption", "Allograft rejection", "Alpha linolenic acid metabolism", "Alzheimers disease", "Amino sugar and nucleotide sugar metabolism", "Aminoacyl trna biosynthesis", "Amyotrophic lateral sclerosis als", "Antigen processing and presentation", "Apoptosis", "Arachidonic acid metabolism", "Arginine and proline metabolism", "Arrhythmogenic right ventricular cardiomyopathy arvc", "Ascorbate and aldarate metabolism", "Autoimmune thyroid disease", "Axon guidance", "B cell receptor signaling pathway", "Basal cell carcinoma", "Basal transcription factors", "Base excision repair", "Beta alanine metabolism", "Biosynthesis of unsaturated fatty acids", "Bladder cancer", "Butanoate metabolism", "Calcium signaling pathway", "Cardiac muscle contraction", "Cell adhesion molecules cams", "Cell cycle", "Chemokine signaling pathway", "Chronic myeloid leukemia", "Citrate cycle tca cycle", "Colorectal cancer", "Cysteine and methionine metabolism", "Cytokine cytokine receptor interaction", "Cytosolic dna sensing pathway", "Dilated cardiomyopathy", "Dna replication", "Dorso ventral axis formation", "Drug metabolism cytochrome p450", "Drug metabolism other enzymes", "Ecm receptor interaction", "Endocytosis", "Endometrial cancer", "Epithelial cell signaling in helicobacter pylori infection", "Erbb signaling pathway", "Ether lipid metabolism", "Fatty acid metabolism", "Fc epsilon ri signaling pathway", "Fc gamma r mediated phagocytosis", "Focal adhesion", "Folate biosynthesis", "Fructose and mannose metabolism", "Galactose metabolism", "Gap junction", "Glioma", "Glutathione metabolism", "Glycerolipid metabolism", "Glycerophospholipid metabolism", "Glycine serine and threonine metabolism", "Glycolysis gluconeogenesis", "Glycosaminoglycan biosynthesis chondroitin sulfate", "Glycosaminoglycan biosynthesis keratan sulfate", "Glycosaminoglycan degradation", "Glycosphingolipid biosynthesis ganglio series", "Glycosphingolipid biosynthesis globo series", "Glycosphingolipid biosynthesis lacto and neolacto series", "Glycosylphosphatidylinositol gpi anchor biosynthesis", "Glyoxylate and dicarboxylate metabolism", "Gnrh signaling pathway", "Graft versus host disease", "Hedgehog signaling pathway", "Hematopoietic cell lineage", "Histidine metabolism", "Homologous recombination", "Huntingtons disease", "Hypertrophic cardiomyopathy hcm", "Inositol phosphate metabolism", "Insulin signaling pathway", "Jak stat signaling pathway", "Leishmania infection", "Leukocyte transendothelial migration", "Limonene and pinene degradation", "Long term depression", "Long term potentiation", "Lysine degradation", "Lysosome", "Mapk signaling pathway", "Maturity onset diabetes of the young", "Melanogenesis", "Melanoma", "Metabolism of xenobiotics by cytochrome p450", "Mismatch repair", "Mtor signaling pathway", "N glycan biosynthesis", "Natural killer cell mediated cytotoxicity", "Neurotrophin signaling pathway", "Nicotinate and nicotinamide metabolism", "Nitrogen metabolism", "Nod like receptor signaling pathway", "Non homologous end joining", "Non small cell lung cancer", "Notch signaling pathway", "Nucleotide excision repair", "O glycan biosynthesis", "Olfactory transduction", "One carbon pool by folate", "Oocyte meiosis", "Other glycan degradation", "Oxidative phosphorylation", "P53 signaling pathway", "Pancreatic cancer", "Pantothenate and coa biosynthesis", "Parkinsons disease", "Pathogenic escherichia coli infection", "Pathways in cancer", "Pentose and glucuronate interconversions", "Pentose phosphate pathway", "Peroxisome", "Phenylalanine metabolism", "Phosphatidylinositol signaling system", "Porphyrin and chlorophyll metabolism", "Ppar signaling pathway", "Primary bile acid biosynthesis", "Primary immunodeficiency", "Prion diseases", "Progesterone mediated oocyte maturation", "Propanoate metabolism", "Prostate cancer", "Proteasome", "Protein export", "Proximal tubule bicarbonate reclamation", "Purine metabolism", "Pyrimidine metabolism", "Pyruvate metabolism", "Regulation of actin cytoskeleton", "Regulation of autophagy", "Renal cell carcinoma", "Renin angiotensin system", "Retinol metabolism", "Riboflavin metabolism", "Ribosome", "Rig i like receptor signaling pathway", "Rna degradation", "Rna polymerase", "Selenoamino acid metabolism", "Small cell lung cancer", "Snare interactions in vesicular transport", "Sphingolipid metabolism", "Spliceosome", "Starch and sucrose metabolism", "Steroid biosynthesis", "Steroid hormone biosynthesis", "Sulfur metabolism", "Systemic lupus erythematosus", "T cell receptor signaling pathway", "Taste transduction", "Terpenoid backbone biosynthesis", "Tgf beta signaling pathway", "Thyroid cancer", "Tight junction", "Toll like receptor signaling pathway", "Tryptophan metabolism", "Type i diabetes mellitus", "Type ii diabetes mellitus", "Tyrosine metabolism", "Ubiquitin mediated proteolysis", "Valine leucine and isoleucine biosynthesis", "Valine leucine and isoleucine degradation", "Vascular smooth muscle contraction", "Vasopressin regulated water reabsorption", "Vegf signaling pathway", "Vibrio cholerae infection", "Viral myocarditis", "Wnt signaling pathway"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ACAA2", "ACACA", "ACACB", "ACADM", "ACADS", 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"BCAT2", "BIRC6", "BLM", "BLVRA", "BRCA1", "BUB1B", "BUB3", "BUD23", "CACYBP", "CAD", "CALD1", "CALR", "CAMK2D", "CAMK2G", "CANX", "CAPN1", "CAPN2", "CARS", "CBR1", "CCDC6", "CDC23", "CDC27", "CDC34", "CDC42", "CDC5L", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CFL1", "CFL2", "CHERP", "CHKA", "CHMP3", "CHORDC1", "CHST14", "CKB", "CKMT1A*", "CLN5", "CLTC", "CMAS", "CMPK1", "CNOT1", "CNOT10", "CNOT3", "CNOT6", "CNOT7", "CNOT9", "COMT", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPOX", "CPT2", "CRKL", "CRNKL1", "CS", "CSK", "CSNK1A1", "CSNK2B", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CWC15", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DARS", "DARS2", "DCPS", "DCTN1", "DCTN2", "DCTN4", "DCXR", "DDB1", "DDOST", "DDX23", "DDX39B", "DDX3X", "DDX42", "DDX46", "DDX5", "DDX6", "DERL1", "DFFA", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", 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17.473300970873787 52.5752427184466 0.7619430018929745 0.3962973483509951 7.757662405441163 5.39117119769307 1.7039672197087123 0.3858226471737118 1.0 0.3867386931517215 0.2570393345333788 3.019421083423849e-05 8.882953739560154e-05 +Gap junction trafficking and regulation 2 8 1.992099900621296 0.0463600978759326 4.633495145631068 11.28640776699029 0.0348608183519093 0.586148089004064 2.81796325564593 1.3583648468018643 0.9454550113075428 0.3181586964978685 1.0 1.0 0.0024390672757694 0.0291459656321865 0.1493820048813357 +Initiation of nuclear envelope ne reformation 2 15 1.971115117979682 0.0487107098889605 5.029126213592233 17.313106796116504 0.6703973563590633 0.4764668209175622 2.443363552582699 1.0411546326925285 0.8298821064609638 0.3128165384367375 1.0 0.0919337377678228 0.1774332758731671 0.0828772873031817 0.068509275445109 diff --git a/msigdb_reactome/metrics.json b/msigdb_reactome/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..0cacc638ff3ca0e0846ebcf64b81aa6fa72fa407 --- /dev/null +++ b/msigdb_reactome/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2454, + "annotations_size": 1318, + "title": "Average number of proteins per term", + "value": 16.749620637329286 +} \ No newline at end of file diff --git a/msigdb_reactome/paths.json b/msigdb_reactome/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..0d91712a97b004935cd84369bb17e315f05b8055 --- /dev/null +++ b/msigdb_reactome/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_reactome/fragment/C340/C340_val_log2fc"} \ No newline at end of file diff --git a/msigdb_reactome/result.tsv b/msigdb_reactome/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..8a9e3f12c6cf6bdf13386638db8f91f0eb3aa457 --- /dev/null +++ b/msigdb_reactome/result.tsv @@ -0,0 +1,443 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Sphingolipid metabolism 0.8008610039743459 3.388709236249699 0.0007022243031782 0.6038081634133816 0.1640822169757951 22 P17900,Q06136,P06280,Q96G23,P04062,P10619,P16278,Q13510,O43681 9 +Glycosphingolipid metabolism 0.8579257774942916 3.1560725230042435 0.0015990909498608 0.8786757777352311 0.1640822169757951 14 P17900,P06280,P04062,P10619,P16278,Q13510,O43681 7 +Metabolism of lipids 0.4965875396757898 3.0833452506874215 0.0020468753491031 0.9328312047018686 0.1640822169757951 126 Q06136,Q9H7Z7,P06280,P50897,P16278,P40939,Q15392,Q14739,O43772,Q8IV08,Q96G23,Q14849,P23786,Q15165,Q16850,Q13510,Q99519,P48449,P10619,Q16836,P16219,Q9UBM7,P17900,Q9UG56,P04062,Q14914,P35790,O43681 28 +Selective autophagy 0.6599223032103947 2.739063038384217 0.0061614558195184 0.9997100841888572 0.1640822169757951 25 Q13501,Q8IWA4,Q9BUF5,Q9BVA1,Q8N4H5,P21796,Q9NS69,P68371 8 +Autophagy 0.6041894996368226 2.7223047440221544 0.0064828330295032 0.9998107023835412 0.1640822169757951 35 Q8IWA4,Q9BUF5,O95140,Q9Y2Q5,Q9BVA1,Q13409,Q8WUX9,Q9Y4P1,Q8N4H5,P21796,Q6IAA8,Q99816,Q15388,P68371,Q9NS69,Q13501 16 +Transport of small molecules 0.4651559809528418 2.693621266363267 0.0070680428540674 0.9999129265246636 0.1640822169757951 130 P30519,P28070,Q8TB61,P49721,Q9HD20,Q8WTV0,P08183,P07237,P21796,P09601,O15439,Q99436,Q15904,P45880,P61421,P28074,P61916,P28072,P63208,Q9H2J7,Q8N4V1,Q9Y277,Q93050,Q9C0H2,Q70HW3,O15118,Q9BUN8,P20618,P60900,P30626,Q9Y487,Q9UBX3,Q99797 33 +Mitochondrial protein import 0.6150760864681395 2.6740118928242596 0.0074949793504839 0.9999506013735716 0.1640822169757951 32 O60830,O14925,Q99595,Q8N4H5,P21796,Q13505,Q9NS69 7 +Nuclear envelope ne reassembly 0.5415880573963008 2.407065528652509 0.0160812840908772 0.9999999994748852 0.1825288189773744 41 Q9BUF5,Q8IXJ6,Q9BVA1,Q86XL3,Q8NFH4,P68371,P37198,Q9BTX1,Q14739 9 +Mitophagy 0.7677635242315003 2.3942089130532023 0.0166562586002767 0.9999999997569688 0.1843201568329952 11 Q8N4H5,P21796,Q9NS69,Q13501 4 +Protein localization 0.4706917124766949 2.344302370978532 0.0190627100851521 0.9999999999903804 0.2014246453483615 61 O60830,O14925,P05067,Q99595,O75874,P46379,Q9NX63,Q8N4H5,Q9NR77,P21796,P09601,Q15067,Q13505,O43681,Q9NS69 15 +Pink1 prkn mediated mitophagy 0.795375647119218 2.338826795303603 0.0193443993580768 0.9999999999934118 0.2014246453483615 9 Q8N4H5,P21796,Q9NS69,Q13501 4 +Cholesterol biosynthesis 0.7292770521494585 2.3218175660348557 0.0202427609890276 0.9999999999980314 0.2084371795588942 12 Q9UBM7,P48449,Q16850,Q14739 4 +Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 0.4771078355567703 2.267006891123395 0.0233898047548124 0.9999999999999716 0.2335436565669909 52 O75880,O14949,P36542,Q9Y375,O75306,P31930,Q16134,O75947,Q8IUX1,P13804,O75964,P56134,P00403,P20674,O43676,Q9NPL8,Q9UDW1,P22695,P24539,Q9P032,Q8N183 21 +The role of gtse1 in g2 m progression after g2 checkpoint 0.5071963359027455 2.251112004749717 0.0243784442713914 0.9999999999999926 0.2415848838322853 45 P28070,Q9BUF5,O75832,P28072,Q9BVA1,P49721,P20618,P60900,Q99436,P28074,P68371 11 +Iron uptake and transport 0.6339271765867909 2.240533993887829 0.0250562764318746 0.999999999999997 0.2464490472926182 18 P30519,P09601,Q93050,Q9Y487,Q15904 5 +Rho gtpases activate iqgaps 0.7839721840883651 2.2161588541983073 0.0266806246978883 0.9999999999999996 0.2523699839560633 8 Q9BUF5,P68371 2 +Sealing of the nuclear envelope ne by escrt iii 0.8764496358578704 2.1596075321784305 0.0308030648397739 1.0 0.2688638374756424 6 Q9BUF5,P68371 2 +Cytoprotection by hmox1 0.4529945738491909 2.155889353289775 0.0310923060170529 1.0 0.2696030219110247 59 P30519,P28070,P28072,P49721,P20618,P60900,P63208,P00403,P20674,P09601,Q99436,P28074 12 +Carboxyterminal post translational modifications of tubulin 0.9259214820547425 2.13523523275018 0.0327418003230779 1.0 0.2721109695191203 4 Q9BUF5,P68371 2 +Metabolism of cofactors 0.925560620388846 2.133817608146028 0.0328577139549826 1.0 0.2721109695191203 4 P00374,O75874 2 +Signaling by interleukins 0.4161221556709102 2.1337988856395507 0.0328592471689819 1.0 0.2721109695191203 95 P28070,P49721,P07237,P09601,Q99436,Q13501,P05067,P11233,P62993,P28074,P52597,P28072,Q13126,P63208,P04083,P20618,P60900,P51809,P22626,Q14738,O14979,Q00169 22 +Sphingolipid de novo biosynthesis 0.7613619165143617 2.114203127671482 0.034497921862018 1.0 0.2789463865898147 8 Q06136 1 +Post chaperonin tubulin folding pathway 0.8627396957110018 2.104282731088308 0.0353537915234383 1.0 0.2834894961618263 6 Q9BUF5,P68371 2 +Assembly and cell surface presentation of nmda receptors 0.7586216570094569 2.1017638809277037 0.035573964573925 1.0 0.2834894961618263 8 Q9BUF5,Q9BVA1,P68371 3 +Synthesis of pe 0.9530995106035892 2.080772346376567 0.0374547484768443 1.0 0.2938414195981005 2 Q9UG56 1 +Regulation of mrna stability by proteins that bind au rich elements 0.4461326130886716 2.0725473888357313 0.0382144216420448 1.0 0.2978798106288788 56 Q15024,Q01105,P28070,O75832,P04792,P28072,Q9Y2L1,P49721,P20618,P60900,Q99436,P28074,Q14103 13 +Gpcr ligand binding 0.748143489989037 2.0540346061636505 0.0399723424250066 1.0 0.3067347612975619 8 P04083,Q9Y3E5,P05067,P42892 4 +Metabolism of steroids 0.5198728417567869 2.0534482992097924 0.0400291190767683 1.0 0.3067347612975619 34 P48449,P04062,Q14849,Q16850,Q9UBM7,Q14739 6 +Cellular response to chemical stress 0.436899718223053 2.0483806774659463 0.0405227133455081 1.0 0.3073763646960997 68 P30519,P28070,P28072,P49721,P20618,P60900,P63208,P07237,P00403,P20674,P09601,Q99436,P28074 13 +Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.6923704283742009 2.0264356111248025 0.042720164772626 1.0 0.3181083455950348 11 P49069,P05067,P46379,P09601,O43681 5 +Neutrophil degranulation 0.4163062988145258 2.00847150369389 0.0445932112454345 1.0 0.3301901821431617 144 P30519,Q9H7Z7,O95721,P42785,P06280,P16278,P61020,O75874,P07437,Q9BTY2,Q13510,Q99519,P68371,P61916,P10619,Q93050,P17900,P20618,P10253,O43681 20 +Respiratory electron transport 0.4850138266993796 1.9970192581021615 0.0458230909991936 1.0 0.3355268552052071 43 Q8IUX1,O75306,P13804,Q8N183,Q9UDW1,P31930,Q16134,P22695,P00403,P20674,O75880,O43676,O14949,Q9P032,Q9Y375 15 +Gap junction trafficking and regulation 0.734630763135221 1.992099900621296 0.0463600978759326 1.0 0.3375834751407692 8 Q9BUF5,P68371 2 +Initiation of nuclear envelope ne reformation 0.6179848014921778 1.971115117979682 0.0487107098889605 1.0 0.348916932791576 15 Q86XL3,Q14739 2 +Metabolism of porphyrins 0.8256453005536144 1.9529251384744424 0.0508284664558289 1.0 0.3598183316911669 6 P30519 1 +Metabolism of folate and pterines 0.7260935531559786 1.9527496373436293 0.0508492688317139 1.0 0.3598183316911669 8 P00374,Q9H2D1 2 +Organelle biogenesis and maintenance 0.4238772618516697 1.9493036466241045 0.0512591733625953 1.0 0.3598183316911669 73 Q15691,Q13409,O60645,P48735,A0AVF1,A6NIH7,P07437,P61163,Q13505,P68371,Q9BUF5,P18085,Q9BVA1,O75964,Q9NX63,Q9BW83,Q00059,O75431,Q92973,Q5XKP0,O75935 21 +Sialic acid metabolism 0.8428715717359139 1.9301413820225968 0.053589322225787 1.0 0.3598183316911669 5 P10619,P16278 2 +Regulation of runx3 expression and activity 0.4991735976566775 1.9285910786166636 0.0537816474530803 1.0 0.3598183316911669 35 P28070,P28072,P49721,P20618,P60900,Q99436,P28074 7 +Gamma carboxylation hypusine formation and arylsulfatase activation 0.706304350793219 1.926258488515359 0.0540721059433144 1.0 0.3599345234004468 9 Q9HA64,P49366,Q9BQC3,O60725,O43681 5 +Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.6078628113781149 1.9131163691560704 0.0557331566359986 1.0 0.361853696779538 15 Q02818,P05067,P07237,Q9BTY2,O43852 5 +The nlrp3 inflammasome 0.8648497956915394 1.89254985944171 0.0584177571035997 1.0 0.3719546080316186 4 P09601 1 +Purinergic signaling in leishmaniasis infection 0.8648497956915391 1.8925498594417067 0.0584177571036002 1.0 0.3719546080316186 4 P09601 1 +Inflammasomes 0.8648497956915391 1.8925498594417067 0.0584177571036002 1.0 0.3719546080316186 4 P09601 1 +Phase i functionalization of compounds 0.642300833567648 1.8749443319075176 0.0608003823317442 1.0 0.3809612021997119 12 P30837,P05091,Q5VT66,O43169,Q16850,P07099,Q15185 7 +Signaling by hedgehog 0.4266289598170897 1.8685118616204448 0.0616907583394401 1.0 0.3809612021997119 54 P28070,Q9BUF5,P28072,Q9BVA1,P49721,P20618,P60900,P63208,P07237,Q96J02,Q99436,P28074,P68371 13 +Negative regulation of notch4 signaling 0.4837728735628114 1.8619304996641877 0.062612887298141 1.0 0.3809612021997119 38 P28070,P28072,P49721,P20618,P60900,P63208,Q99436,P28074 8 +Auf1 hnrnp d0 binds and destabilizes mrna 0.4751946264218293 1.858902743807184 0.0630409251228083 1.0 0.3809612021997119 41 P28070,P04792,P28072,P49721,P20618,P60900,Q99436,P28074,Q14103 9 +Mitochondrial biogenesis 0.5234850467051749 1.8524637523612075 0.0639592579751107 1.0 0.3809612021997119 26 O75431,P36542,O75947,O75964,P56134,Q9NX63,P24539,Q5XKP0,P48735,Q00059,Q13505 11 +Heme degradation 0.9724583984196932 1.8507714999923324 0.0642024328182171 1.0 0.3809612021997119 3 P30519 1 +Gap junction assembly 0.9722562219502244 1.8500009811798488 0.0643134081741507 1.0 0.3809612021997119 3 Q9BUF5,P68371 2 +Transport of connexons to the plasma membrane 0.9722562219502244 1.8500009811798488 0.0643134081741507 1.0 0.3809612021997119 3 Q9BUF5,P68371 2 +Activation of ampk downstream of nmdars 0.9722562219502244 1.8500009811798488 0.0643134081741507 1.0 0.3809612021997119 3 Q9BUF5,P68371 2 +Cyclin a cdk2 associated events at s phase entry 0.4740695157152956 1.849324842495366 0.0644109206628793 1.0 0.3809612021997119 41 P28070,P28072,P49721,P20618,P60900,P63208,P31751,Q99436,P28074 9 +Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand 0.5211917601509661 1.8362140161972291 0.0663260105221077 1.0 0.3868039020714071 26 Q9BUF5,Q9BVA1,Q13409,P61163,O75935,P68371 6 +Hedgehog off state 0.4478147970917663 1.8261163584445963 0.0678327366415671 1.0 0.3937239265462783 48 P28070,Q9BUF5,P28072,Q9BVA1,P49721,P20618,P60900,P63208,Q96J02,Q99436,P28074,P68371 12 +The citric acid tca cycle and respiratory electron transport 0.4029053635977557 1.824277983838565 0.0681100570960178 1.0 0.3937239265462783 84 O75306,P13804,Q9UDW1,P31930,Q16134,O75964,P00403,P21796,P20674,O43676,Q15120,P48735,O14949,Q9Y375 14 +Interleukin 1 signaling 0.4610258734002399 1.8169301078696096 0.069227815881526 1.0 0.3956671519416329 44 P28070,P28072,P05067,P49721,P20618,P60900,P63208,Q99436,P28074,Q13501 10 +Signaling by notch4 0.4726099230214455 1.812898977473371 0.0698474039880072 1.0 0.3956671519416329 40 P28070,O75832,P28072,Q13573,P49721,P20618,Q92542,P60900,P63208,Q9UL46,Q99436,P28074 12 +Glycosaminoglycan metabolism 0.6495986253498568 1.8106135515007704 0.0702006930061993 1.0 0.3956671519416329 11 O43505,Q8TB61,Q8NCH0,P54802,P16278,P15586 6 +Class a 1 rhodopsin like receptors 0.7427768572288509 1.8102060832795552 0.0702638346018571 1.0 0.3956671519416329 7 P04083,P05067,P42892 3 +Peptide ligand binding receptors 0.7427768572288509 1.8102060832795552 0.0702638346018571 1.0 0.3956671519416329 7 P04083,P05067,P42892 3 +Mrna decay by 3 to 5 exoribonuclease 0.6295801763115362 1.807644572921652 0.070661836269084 1.0 0.3956671519416329 12 Q15024,Q9GZS3,Q9Y2L1,Q969T7,Q96C86,Q9Y3B2 6 +Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways 0.785864315449778 1.7879903311863996 0.0737775677732699 1.0 0.4034806403534016 6 P05067,P09601 2 +Cdt1 association with the cdc6 orc origin complex 0.4751635591979369 1.7713615363761548 0.0765006004718902 1.0 0.4079393641869078 37 Q9Y619,P28070,P28072,P49721,P20618,P60900,Q99436,P28074 8 +Uch proteinases 0.4551115596062008 1.764385108404798 0.0776671636241923 1.0 0.4111057094646004 44 P85037,P28070,P28072,P49721,P20618,P60900,O96019,Q8NB78,Q99436,P28074 10 +Antigen processing cross presentation 0.439659567549017 1.7497492192902475 0.080161596598683 1.0 0.4161865666217614 48 P28070,O75832,P28072,P49721,P20618,P60900,Q9UIQ6,Q99436,P28074 9 +Interleukin 12 signaling 0.5019983646688797 1.7421089980875193 0.0814893733910073 1.0 0.4161865666217614 28 P52597,Q13126,P51809,P22626,P07237,P11233,P78417,O14979,Q00169 9 +Irs mediated signalling 0.8723491027732468 1.7404230253244222 0.0817847653680072 1.0 0.4161865666217614 2 P31751 1 +Insulin receptor signalling cascade 0.8723491027732468 1.7404230253244222 0.0817847653680072 1.0 0.4161865666217614 2 P31751 1 +Signalling to ras 0.8723491027732444 1.7404230253244108 0.0817847653680092 1.0 0.4161865666217614 2 P11233 1 +Slc mediated transmembrane transport 0.5661141184286013 1.7301641942150805 0.0836009435934428 1.0 0.4209532258505143 16 Q8TB61,P30626,Q9H2J7,P55011,Q9UBX3,Q70HW3 6 +Rac2 gtpase cycle 0.5024395857179548 1.7229730376685188 0.0848934009537607 1.0 0.4254353705591508 27 Q86XL3,O15173,Q9UH62,Q13505,Q14739 5 +Scf skp2 mediated degradation of p27 p21 0.4598309559994086 1.7042973468443776 0.0883255504003797 1.0 0.4300336586534078 40 P28070,P28072,P49721,P20618,P60900,P63208,Q99436,P28074 8 +Runx1 regulates transcription of genes involved in differentiation of hscs 0.4566760349020988 1.677302418330899 0.0934833599224029 1.0 0.4384735529456481 40 P28070,P28072,P49721,P20618,P60900,Q03164,Q96J02,Q99436,P28074 9 +Cristae formation 0.5413337929900055 1.673232288169315 0.0942815763718083 1.0 0.4390101769605474 18 P36542,O75947,O75964,P56134,Q9NX63,P24539,Q5XKP0,Q13505,O75431 9 +Interconversion of nucleotide di and triphosphates 0.563930655492376 1.6570716528992058 0.0975049894448991 1.0 0.4424882401037752 15 Q9H773,P23919,P15531,P04818,P17812,P54819 6 +Kinesins 0.5822597298085339 1.655567135410831 0.0978095102359415 1.0 0.4424882401037752 13 Q9BUF5,Q9BVA1,P68371 3 +Translocation of slc2a4 glut4 to the plasma membrane 0.4956250963180169 1.6531339764121782 0.0983035998404546 1.0 0.4424882401037752 26 Q9BUF5,Q9BVA1,Q9UIQ6,P61106,P31751,O60645,P11233,P27348,P68371 9 +Interleukin 1 family signaling 0.4392192062597166 1.649916101231316 0.098960097057573 1.0 0.4435238137741795 45 P28070,P28072,P05067,P49721,P20618,P60900,P63208,Q99436,P28074,Q13501 10 +Diseases associated with glycosylation precursor biosynthesis 0.6612269192549458 1.6483968435662897 0.0992712633257837 1.0 0.4435238137741795 8 P10619,P16278 2 +Signaling by the b cell receptor bcr 0.4529053398307095 1.6449449063869164 0.0999811730873549 1.0 0.4451864396254523 40 P28070,P28072,P49721,P20618,P60900,P63208,Q99436,P62993,P28074 9 +Biological oxidations 0.4712019213180426 1.6402170862424192 0.1009600379354012 1.0 0.4480314141375717 33 P21964,Q8TB61,P30837,P05091,O14880,Q5VT66,O43169,O60701,O75223,Q16850,P78417,P07099,Q9NUJ1,Q15185 14 +Intraflagellar transport 0.6572007345443599 1.6292105476547774 0.1032684548471956 1.0 0.4513957252191481 8 Q9BUF5,P68371,Q9BVA1,A0AVF1 4 +Mitotic g2 g2 m phases 0.3948407547922049 1.6286137292831655 0.1033948160034556 1.0 0.4513957252191481 73 P28070,Q9BUF5,P28072,Q9BVA1,P49721,P20618,P60900,Q13409,P63208,P07437,P61163,O75935,Q99436,P28074,P68371 15 +Egr2 and sox10 mediated initiation of schwann cell myelination 0.7697159042244854 1.6278351761842804 0.1035598395962686 1.0 0.4513957252191481 5 Q16850 1 +Keratan sulfate keratin metabolism 0.769682389060704 1.6276950164537298 0.1035895703428591 1.0 0.4513957252191481 5 O43505,P16278 2 +Mitotic g1 phase and g1 s transition 0.3996992824622336 1.6268306558991037 0.1037730688478011 1.0 0.4513957252191481 64 Q9Y619,P28070,P28072,P49721,P20618,P60900,P63208,P31751,P00374,Q99436,P35244,P28074 12 +Aggrephagy 0.5944290910923916 1.619228585051656 0.1053980897817838 1.0 0.4554579748602989 12 Q9BUF5,P68371 2 +Diseases of glycosylation 0.5656038232078135 1.611899536897882 0.1069838029975094 1.0 0.4592991841036747 14 O75340,P16278,P10619,Q99519 4 +Beta oxidation of butanoyl coa to acetyl coa 0.793644395703129 1.6032272617108407 0.1088844887577902 1.0 0.4614862079440977 4 Q16836,P40939 2 +Regulation of pten stability and activity 0.4503518135225565 1.602310040318675 0.1090870665358652 1.0 0.4614862079440977 39 P28070,P28072,P49721,P20618,P60900,P31751,Q99436,P28074 8 +G1 s specific transcription 0.6510878933275539 1.6000196654355163 0.109594220854706 1.0 0.4614862079440977 8 P00374 1 +Synthesis of substrates in n glycan biosythesis 0.5717690280462068 1.5964852891020889 0.1103804875976293 1.0 0.4633168237378198 13 P10619,P16278 2 +Abc family proteins mediated transport 0.4266715041714302 1.5942776472958553 0.1108738618977416 1.0 0.4639103174007093 47 P28070,P28072,Q9BUN8,P49721,P20618,P60900,P08183,Q99436,P28074,O15439 10 +Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation 0.9031380737702478 1.584548695039582 0.1130689095611638 1.0 0.4715975405114367 3 P00374 1 +Mucopolysaccharidoses 0.7869387755102017 1.5756866581493534 0.1150980337072313 1.0 0.4740600263316592 4 P15586,P54802,P16278 3 +Degradation of gli1 by the proteasome 0.4424215566414024 1.5544524010928764 0.1200765421542142 1.0 0.4862640645629325 40 P28070,P28072,P49721,P20618,P60900,P63208,Q96J02,Q99436,P28074 9 +Mitochondrial calcium ion transport 0.5548254557871203 1.549410569333299 0.1212830546127381 1.0 0.4862640645629325 14 P21796 1 +Signaling by fgfr 0.5542053756971682 1.545804861047485 0.1221517027054421 1.0 0.4862640645629325 14 P52597,P31943,Q01085,P62993,P31483,P19388 6 +Signaling by fgfr2 0.5542053756971682 1.545804861047485 0.1221517027054421 1.0 0.4862640645629325 14 P52597,P31943,Q01085,P62993,P31483,P19388 6 +Regulation of hmox1 expression and activity 0.4307994856264715 1.5454911220061271 0.1222275146877496 1.0 0.4862640645629325 44 P28070,P28072,P49721,P20618,P60900,P63208,P09601,Q99436,P28074 9 +Cross presentation of soluble exogenous antigens endosomes 0.4495578781575782 1.542645903788448 0.1229167139083395 1.0 0.4862640645629325 36 P28070,P28072,P49721,P20618,P60900,Q99436,P28074 7 +Degradation of axin 0.4495578781575782 1.542645903788448 0.1229167139083395 1.0 0.4862640645629325 36 P28070,P28072,P49721,P20618,P60900,Q99436,P28074 7 +Hedgehog on state 0.4403702757791169 1.536657224506875 0.1243772712832411 1.0 0.4862640645629325 40 P28070,P28072,P49721,P20618,P60900,Q96J02,Q99436,P28074 8 +Tristetraprolin ttp zfp36 binds and destabilizes mrna 0.6377836667705102 1.536242958388133 0.1244788036651862 1.0 0.4862640645629325 8 Q15024,Q92973,Q9Y3B2,Q9Y2L1 4 +Signaling by erbb4 0.6795217998884238 1.5272940509426982 0.126687908133507 1.0 0.491101949764595 7 Q92542,P62993,Q96J02 3 +Formyl peptide receptors bind formyl peptides and many other ligands 0.8867708539260755 1.5212172634924643 0.128205324615223 1.0 0.4955267385421231 3 P05067 1 +Defective cftr causes cystic fibrosis 0.4382216226769579 1.5179866119802583 0.1290177737383477 1.0 0.4957592588546425 40 P28070,P28072,Q9BUN8,P49721,P20618,P60900,Q99436,P28074 8 +Abc transporter disorders 0.4382216226769579 1.5179866119802583 0.1290177737383477 1.0 0.4957592588546425 40 P28070,P28072,Q9BUN8,P49721,P20618,P60900,Q99436,P28074 8 +Switching of origins to a post replicative state 0.3923786412747579 1.5148910503378792 0.1297999971858507 1.0 0.4973151054969515 54 Q9Y619,P28070,P28072,P49721,Q96DE5,P20618,P60900,P63208,Q16763,Q99436,P28074 11 +Rac3 gtpase cycle 0.4831932139090512 1.5024113791050098 0.1329908994012851 1.0 0.5063325969302183 24 Q14739 1 +Activation of bad and translocation to mitochondria 0.6303363632293295 1.5004034423064048 0.1335099284006733 1.0 0.5063325969302183 8 P61981,P31751,P27348,Q04917 4 +Downstream signaling events of b cell receptor bcr 0.4403461957908564 1.4982264992780563 0.1340744129959379 1.0 0.5063325969302183 38 P28070,P28072,P49721,P20618,P60900,P63208,Q99436,P28074 8 +Neurotransmitter clearance 0.8144371941272437 1.4927358219639473 0.1355063525687498 1.0 0.5078730383903669 2 P21964 1 +Biosynthesis of specialized proresolving mediators spms 0.8136215334420772 1.4892359629545089 0.1364252438088713 1.0 0.5078730383903669 2 Q14914 1 +Synthesis of leukotrienes lt and eoxins ex 0.8136215334420772 1.4892359629545089 0.1364252438088713 1.0 0.5078730383903669 2 Q14914 1 +Fc epsilon receptor fceri signaling 0.4243768406493928 1.4869121180912608 0.1370380232734798 1.0 0.5078730383903669 44 P28070,O75832,P28072,P49721,P20618,P60900,P63208,Q99436,P62993,P28074 10 +Metabolism of polyamines 0.4409114079984866 1.4860935468290593 0.1372543789714373 1.0 0.5078730383903669 37 P28070,P28072,P49721,P20618,P60900,Q99436,P28074 7 +Asymmetric localization of pcp proteins 0.439660067098418 1.4755270606685735 0.1400708985422538 1.0 0.5097435813972832 37 P28070,P28072,P49721,P20618,P60900,Q99436,P28074 7 +Recruitment of numa to mitotic centrosomes 0.4652639315350108 1.4688641904385007 0.1418696291242851 1.0 0.5097435813972832 28 Q9BUF5,Q9BVA1,P07437,P61163,O75935,P68371 6 +Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 0.5407859335353216 1.4674978541116013 0.142240672585894 1.0 0.5097435813972832 14 P10619,P16278,Q99519 3 +Deadenylation dependent mrna decay 0.4528635413882227 1.466486347916922 0.1425158377640223 1.0 0.5097435813972832 32 Q9H9A5,Q15024,Q9GZS3,Q92600,Q9Y2L1,Q9UIV1,Q969T7,Q9NQT5,Q96C86,P62312,Q9Y3B2 11 +Miro gtpase cycle 0.7598526971971389 1.464046468619551 0.1431812521324591 1.0 0.5097435813972832 4 Q8IWA4 1 +Regulation of localization of foxo transcription factors 0.7093012999252557 1.4638315253269456 0.1432399864507179 1.0 0.5097435813972832 6 P31751,P27348 2 +Regulation of ras by gaps 0.4381698766031217 1.462931062482184 0.143486243321997 1.0 0.5097435813972832 37 P28070,P28072,P49721,P20618,P60900,Q99436,P28074 7 +Degradation of dvl 0.4381698766031217 1.462931062482184 0.143486243321997 1.0 0.5097435813972832 37 P28070,P28072,P49721,P20618,P60900,Q99436,P28074 7 +Tnfr2 non canonical nf kb pathway 0.4311990402691236 1.4567487948188798 0.145185735147215 1.0 0.511668054112106 40 P28070,P28072,P49721,P20618,P60900,P63208,Q99436,P28074 8 +Dectin 1 mediated noncanonical nf kb signaling 0.4311990402691237 1.4567487948188798 0.145185735147215 1.0 0.511668054112106 40 P28070,P28072,P49721,P20618,P60900,P63208,Q99436,P28074 8 +Beta oxidation of hexanoyl coa to butanoyl coa 0.7284429359805323 1.4543010172745832 0.1458628685596235 1.0 0.5117315154889494 5 Q16836,P40939 2 +Rhoa gtpase cycle 0.4400977308134199 1.4496353156231816 0.1471602424083609 1.0 0.5144753302233943 35 P30519,Q15904,Q14739 3 +Hedgehog ligand biogenesis 0.4296193992988844 1.4429295066182122 0.1490403301614919 1.0 0.517036026731959 40 P28070,P28072,P49721,P20618,P60900,P07237,Q99436,P28074 8 +Adora2b mediated anti inflammatory cytokines production 0.7042227950591013 1.4420711674452542 0.1492822978980397 1.0 0.517036026731959 6 P04899,P08754,Q9Y3E5,P10644 4 +Synthesis of dna 0.3793220443861023 1.4403083869674496 0.1497801696203939 1.0 0.517036026731959 71 Q9Y619,P41440,P28070,P28072,P49721,Q96DE5,P20618,P60900,P63208,P35250,Q16763,Q99436,Q9BRT9,P35244,P28074 15 +Nrif signals cell death from the nucleus 0.8013866231647531 1.4367244072457288 0.1507963169462289 1.0 0.517036026731959 2 Q13501 1 +Transport of inorganic cations anions and amino acids oligopeptides 0.6594672904696586 1.4362926728786851 0.1509190781174934 1.0 0.517036026731959 7 P30626,Q9H2J7,Q9UBX3,Q70HW3 4 +Signaling by insulin receptor 0.5774933319580285 1.4358992592174598 0.1510310093261033 1.0 0.517036026731959 11 P61421,P31751,Q93050,Q9Y487,Q15904 5 +Formation of tubulin folding intermediates by cct tric 0.5770295233741582 1.4334501955460266 0.1517292223029951 1.0 0.5180806087962372 11 Q9BUF5,P68371 2 +Signaling by type 1 insulin like growth factor 1 receptor igf1r 0.863600256537606 1.431380401732114 0.1523212221140448 1.0 0.5187580639439564 3 P31751 1 +Transcriptional regulation by runx2 0.4150200107487478 1.4268787305855264 0.1536148525574314 1.0 0.5218154012131305 45 P28070,P28072,P49721,P20618,P60900,P63208,P31751,Q99436,P28074,Q96PK6 10 +Ksrp khsrp binds and destabilizes mrna 0.6029329014340844 1.4238845610254265 0.1544798917466159 1.0 0.5234048774345496 9 Q15024,Q92945,Q9NQT5,Q9Y2L1,Q9Y3B2 5 +Stabilization of p53 0.4328844213358963 1.4181461128864508 0.1561481107072226 1.0 0.5263509204913542 37 P28070,P28072,P49721,P20618,P60900,Q99436,P28074 7 +Interleukin 12 family signaling 0.4525407257064078 1.4147155770044724 0.1571519053430123 1.0 0.5268217818282318 30 P52597,Q13126,P51809,P22626,P07237,P11233,P78417,O14979,Q00169 9 +Fceri mediated nf kb activation 0.4261921863502991 1.41289193215793 0.1576875016388497 1.0 0.5268217818282318 40 P28070,O75832,P28072,P49721,P20618,P60900,P63208,Q99436,P28074 9 +Apoptotic factor mediated response 0.795676998368667 1.412215053680839 0.1578866493339541 1.0 0.5268217818282318 2 Q9NR28 1 +Copi independent golgi to er retrograde traffic 0.4807558211086847 1.4082243907564809 0.1590646360806891 1.0 0.5280785651243028 22 Q9BUF5,Q9BVA1,Q13409,P61163,O75935,P68371 6 +Clec7a dectin 1 signaling 0.4167851194397178 1.3930188268922528 0.1636140975671498 1.0 0.5391520977492418 43 P28070,O75832,P28072,P49721,P20618,P60900,P63208,Q99436,P28074 9 +Orc1 removal from chromatin 0.4054770461803641 1.3929750229804596 0.163627343778222 1.0 0.5391520977492418 47 Q9Y619,P28070,P28072,P49721,P20618,P60900,P63208,Q99436,P28074 9 +Response to elevated platelet cytosolic ca2 0.461923184473284 1.3905184047267831 0.164371514456447 1.0 0.5402535063680728 25 P07737,P05067,Q8NBX0,O15439,O43852,Q08380 6 +Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 0.410438172735878 1.3841602878659665 0.166309380163546 1.0 0.5449355032415709 45 P28070,P28072,P49721,Q96DE5,P20618,P60900,Q16763,Q99436,P28074 9 +Gene and protein expression by jak stat signaling after interleukin 12 stimulation 0.4584504727433218 1.3809678147281084 0.1672888569426232 1.0 0.5457591917088549 26 P52597,Q13126,P22626,P11233,P78417,O14979,Q00169 7 +Cooperation of prefoldin and tric cct in actin and tubulin folding 0.5170265826812676 1.3765544070448597 0.1686500552041647 1.0 0.5477218292233211 15 Q9BUF5,P68371 2 +G1 s dna damage checkpoints 0.4259592074700865 1.3749815466163813 0.1691371657768525 1.0 0.5477218292233211 38 P28070,P28072,P49721,P20618,P60900,Q99436,P28074 7 +Signaling by notch 0.3901364796905253 1.3725816303420892 0.1698824458343764 1.0 0.5487869206120296 51 P28070,O75832,P28072,Q13573,P49721,P20618,Q92542,P60900,P63208,Q9UL46,Q96J02,Q99436,P28074,Q9UBV2 14 +Translesion synthesis by polk 0.5900893591835995 1.3600117052776437 0.1738262197934506 1.0 0.557408257604384 9 P41440,P35250 2 +Insulin receptor recycling 0.5898253045347839 1.3586959832160277 0.1742429454726906 1.0 0.557408257604384 9 Q93050,Q9Y487,Q15904 3 +Transcriptional regulation by runx3 0.4202463026151529 1.342419171005913 0.1794601221542007 1.0 0.5678251015246967 39 P28070,O75832,P28072,Q13573,P49721,P20618,P60900,Q99436,P28074 9 +Cilium assembly 0.3997108776660872 1.3376182963625092 0.1810208970512872 1.0 0.5678251015246967 47 Q9BUF5,Q15691,P18085,Q9BVA1,Q9BW83,Q13409,Q92973,P07437,P61163,O75935,A0AVF1,A6NIH7,P68371 13 +Adenylate cyclase inhibitory pathway 0.7777324632952722 1.335210595282506 0.1818074300784689 1.0 0.5678251015246967 2 P04899 1 +G alpha z signalling events 0.7777324632952722 1.335210595282506 0.1818074300784689 1.0 0.5678251015246967 2 P04899 1 +Gaba b receptor activation 0.7777324632952722 1.335210595282506 0.1818074300784689 1.0 0.5678251015246967 2 P04899 1 +Adp signalling through p2y purinoceptor 12 0.7777324632952722 1.335210595282506 0.1818074300784689 1.0 0.5678251015246967 2 P04899 1 +Tcr signaling 0.4099843568935282 1.3309551810210976 0.183203758668581 1.0 0.5693188289281057 43 P28070,O75832,P28072,P49721,P20618,P60900,P63208,Q99436,P28074 9 +C type lectin receptors clrs 0.4046271969735107 1.3297735041291656 0.1835929082717502 1.0 0.5693188289281057 45 P28070,O75832,P28072,P49721,P20618,P60900,P63208,Q99436,P28074 9 +Dna replication pre initiation 0.3785521613563039 1.328357174661424 0.1840601399788202 1.0 0.5693188289281057 53 Q9Y619,P28070,P28072,P49721,P20618,P60900,Q99436,P35244,P28074 9 +Mapk6 mapk4 signaling 0.3986250262646402 1.3271673732462537 0.1844533225487248 1.0 0.5693188289281057 47 P28070,P04792,P28072,P49721,P20618,P60900,Q99436,P28074 8 +Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex 0.5943264232929587 1.3258860795685503 0.1848774345836337 1.0 0.5693188289281057 8 Q9Y3B8,Q04917,P06493,P62258,P61981,P27348 6 +Recycling pathway of l1 0.4986253516178517 1.3160105243009286 0.1881705103287108 1.0 0.5764841771054924 16 Q9BUF5,P68371 2 +Fgfr2 alternative splicing 0.5380719736313622 1.31050752512544 0.1900242001986556 1.0 0.5764841771054924 12 P52597,P31943,Q01085,P31483,P19388 5 +Flt3 signaling 0.8314432864844534 1.3065722776610884 0.1913580169071145 1.0 0.5764841771054924 3 P31751 1 +Regulated proteolysis of p75ntr 0.7703915171288749 1.3037368212348557 0.1923233303734155 1.0 0.5764841771054924 2 Q92542 1 +Activation of nmda receptors and postsynaptic events 0.5047969465434192 1.302382337493933 0.1927857173835656 1.0 0.5764841771054924 15 Q9BUF5,Q9BVA1,P68371 3 +Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 0.5775357379806114 1.297358883754008 0.1945077326361879 1.0 0.5764841771054924 9 Q9H9A5,Q92600,Q9UIV1 3 +Pcp ce pathway 0.4011261560987246 1.2968978469215229 0.1946663374391213 1.0 0.5764841771054924 45 P28070,P07737,P28072,P49721,P20618,P60900,Q99436,P28074 8 +Copi mediated anterograde transport 0.4104108062829305 1.292482797854756 0.1961899994100053 1.0 0.5764841771054924 41 Q9BUF5,Q9BVA1,Q13409,P62820,P61923,P61163,O75935,P24390,P68371 9 +Plasma lipoprotein assembly 0.7671288743882516 1.2897568705504454 0.1971350869754975 1.0 0.5764841771054924 2 P07237 1 +Costimulation by the cd28 family 0.575632352633346 1.2878427198056877 0.1978007180801539 1.0 0.5767728903310685 9 P31751,Q14738 2 +Deubiquitination 0.3612629314661017 1.264851689346162 0.2059244981196595 1.0 0.5824216491882216 76 P45880,P85037,P28070,P28072,P49721,P20618,Q9NXR7,P60900,O96019,Q8NB78,P21796,Q9Y277,Q99436,P28074 14 +Beta oxidation of lauroyl coa to decanoyl coa coa 0.7105535291101744 1.2597998413236415 0.2077415770545907 1.0 0.5837160066994499 4 Q16836 1 +Negative regulation of the pi3k akt network 0.661684456024624 1.2589716203299983 0.2080405827058991 1.0 0.5837160066994499 6 P31751,Q14738 2 +Dna replication 0.3605483231769574 1.2498182125635378 0.2113659614968568 1.0 0.5902125789255451 75 Q9Y619,P41440,P28070,P28072,P49721,Q96DE5,P20618,P60900,P63208,P35250,Q16763,Q99436,Q9BRT9,P35244,P28074 15 +Transferrin endocytosis and recycling 0.5417414071002763 1.2460063575401823 0.2127620611723557 1.0 0.5928549611525684 11 Q93050,Q9Y487,Q15904 3 +Butyrate response factor 1 brf1 binds and destabilizes mrna 0.6157557872312931 1.2364191797467214 0.2163027904210996 1.0 0.5975337869097194 7 Q15024,Q9Y3B2,Q9Y2L1,Q9NQT5 4 +Ctla4 inhibitory signaling 0.8133243898048134 1.2363219749755547 0.2163389059285232 1.0 0.5975337869097194 3 Q14738 1 +Activation of gene expression by srebf srebp 0.506903809274691 1.224774726894712 0.2206601097661882 1.0 0.6044579397165353 13 P48449,Q16850 2 +Cellular response to hypoxia 0.4065622795799651 1.2224920320941053 0.22152161521929 1.0 0.6044579397165353 39 P28070,P28072,P49721,P20618,P60900,Q99436,P28074 7 +Tp53 regulates transcription of cell cycle genes 0.4914921234100527 1.2213041110799985 0.2219708974376351 1.0 0.6044579397165353 15 Q9H9A5,Q92600,Q9UIV1 3 +Synaptic adhesion like molecules 0.6729075248767409 1.2187954968128183 0.222921821118891 1.0 0.6050436053998419 5 O95197 1 +Aquaporin mediated transport 0.700552003644253 1.2183155286565388 0.2231040912172406 1.0 0.6050436053998419 4 Q99797,P10644 2 +Atf4 activates genes in response to endoplasmic reticulum stress 0.5601471192976013 1.2102889695047552 0.2261680288048326 1.0 0.6051963870136237 9 Q15024,Q92945,Q9NQT5,Q9Y2L1,Q9Y3B2 5 +Glucuronidation 0.8064613745864434 1.209750428931039 0.2263746728359001 1.0 0.6051963870136237 3 Q9NUJ1 1 +Ion channel transport 0.4418005783711198 1.204385182118446 0.2284407365946168 1.0 0.6094835846795648 24 P61421,P30626,Q93050,Q9Y487,Q15904,Q9C0H2 6 +Wnt ligand biogenesis and trafficking 0.6936921396314761 1.1898745251231488 0.2340957124989275 1.0 0.6183129239951634 4 O60493 1 +Deadenylation of mrna 0.4861533322806265 1.1886739623097466 0.2345679904992093 1.0 0.6183212229559156 15 Q9H9A5,Q92600,Q9UIV1 3 +Metabolism of steroid hormones 0.8001260217413965 1.1852473953465408 0.2359196456720815 1.0 0.6194065597525966 3 Q14849 1 +Extra nuclear estrogen signaling 0.599127799327684 1.1600625757003071 0.2460233297829801 1.0 0.6328668852180371 7 P04899,P31751,P04792 3 +Nuclear signaling by erbb4 0.6861728761531789 1.158719951104145 0.2465703557393446 1.0 0.6328668852180371 4 Q92542 1 +Mitotic metaphase and anaphase 0.3382011698238639 1.158136144782925 0.2468084817921632 1.0 0.6328668852180371 117 P28070,P49721,Q86XL3,Q13409,Q99436,P37198,Q14739,Q8IXJ6,Q8NFH4,P68371,Q9BUF5,P28072,Q9BVA1,Q96DE5,P20618,P60900,Q14738,Q16763,Q9BTX1 19 +Beta catenin independent wnt signaling 0.3809899609356952 1.1563565266674334 0.2475353558519373 1.0 0.6334982505103949 47 P28070,P07737,P28072,P49721,P20618,P60900,Q99436,P28074 8 +O linked glycosylation 0.7915261462618517 1.1520335231951355 0.2493072980589852 1.0 0.6355648333495987 3 Q10472 1 +O linked glycosylation of mucins 0.7915261462618517 1.1520335231951355 0.2493072980589852 1.0 0.6355648333495987 3 Q10472 1 +Mitochondrial fatty acid beta oxidation of saturated fatty acids 0.5960825656118913 1.1460725904611395 0.251765117684239 1.0 0.6405915542622144 7 Q16836,P40939 2 +Degradation of beta catenin by the destruction complex 0.381455771352041 1.1349602130362832 0.2563919891666271 1.0 0.6463412054888908 46 P28070,P28072,P49721,P20618,P60900,P63208,Q14738,Q99436,P28074 9 +Hs gag degradation 0.786617707058352 1.133105145103941 0.2571701009741707 1.0 0.6463412054888908 3 P54802,P16278 2 +Heparan sulfate heparin hs gag metabolism 0.786617707058352 1.133105145103941 0.2571701009741707 1.0 0.6463412054888908 3 P54802,P16278 2 +Intra golgi traffic 0.5930492261735465 1.1321371028305425 0.2575767982482513 1.0 0.6463412054888908 7 O00461 1 +Regulation of runx2 expression and activity 0.3923652967872599 1.1299560355897096 0.2584947502722821 1.0 0.6463412054888908 41 P28070,P28072,P49721,P20618,P60900,P63208,Q99436,P28074 8 +Extracellular matrix organization 0.4304566362717023 1.1216717233973008 0.2620020435552712 1.0 0.6503176900298446 24 O15460,P05067,Q92542,O75718,Q32P28,Q03001,P07237,P13674 8 +Protein protein interactions at synapses 0.5305497652408006 1.1126445994456595 0.2658610977576345 1.0 0.6574201254119368 10 Q14168,O95197 2 +Signaling by nuclear receptors 0.3899994935363752 1.1085333524023202 0.2676315433718992 1.0 0.6585339809362575 41 P04792,O94788,Q08752,P31751,Q8NB78,Q8NBN7,Q15120,P19388 8 +Diseases of carbohydrate metabolism 0.5498030298272513 1.1082388481066028 0.2677586774628893 1.0 0.6585339809362575 8 P15586,P54802,P10253,P16278 4 +Ub specific processing proteases 0.3526012404844825 1.101807002814029 0.2705455852867267 1.0 0.6595405602523104 62 P45880,P28072,P20618,P49721,P21796 5 +Gaba receptor activation 0.7780497756018002 1.100123020582604 0.2712785249159444 1.0 0.6595405602523104 3 P04899,Q9Y639 2 +G alpha s signalling events 0.7780497756017962 1.100123020582588 0.2712785249159513 1.0 0.6595405602523104 3 P04899,Q9Y3E5 2 +G2 m checkpoints 0.3481070409788076 1.0980433769181854 0.2721855486240261 1.0 0.6595405602523104 74 Q9Y619,P28070,P28072,P49721,P20618,Q9NXR7,P60900,O96028,P35250,Q99436,P35244,Q9UQ84 12 +S phase 0.3437098024644901 1.0914576626808676 0.2750715514782231 1.0 0.6598260634641896 81 Q9Y619,P41440,P28070,P28072,P20618,P49721,Q96DE5,P60900,P63208,P35250,Q16763,P31751,Q99436,Q9BRT9,P35244,P28074 16 +Cdc42 gtpase cycle 0.4334477408136626 1.077224298623888 0.2813800723581763 1.0 0.6676847744504973 22 Q14739 1 +Leishmania infection 0.4174593350384861 1.0741252235661207 0.2827665608874592 1.0 0.6676847744504973 26 P08754,P05067,Q9UQB8,P78536,P09601,P10644,P04899,P62993,Q9Y3E5 9 +Activated notch1 transmits signal to the nucleus 0.770705834353328 1.071920118276924 0.2837559130907185 1.0 0.6678398097385126 3 Q92542,Q96J02 2 +Apc c mediated degradation of cell cycle proteins 0.3601916118033547 1.0654260243860991 0.2866831851804459 1.0 0.6723281816153517 51 P28070,P28072,P49721,Q96DE5,P20618,P60900,P63208,Q16763,Q99436,P28074 10 +Translation of replicase and assembly of the replication transcription complex 0.7141109298531847 1.064030147362307 0.2873150426825583 1.0 0.6726131905073035 2 Q8WUX9 1 +Innate immune system 0.3725552189897549 1.0596562130988578 0.2893010299858698 1.0 0.6737346855893396 229 P30519,P28070,Q9H7Z7,P49721,P42785,O95721,P06280,P16278,P09601,P61421,P05067,P61020,Q8IV08,O75874,P07437,Q9BTY2,Q13510,P68371,Q99519,P61916,O00584,P28072,Q9UQB8,P10619,Q93050,P17900,P11279,P20618,P60900,Q9Y487,P10253,O43681 32 +Complex i biogenesis 0.4305395954293891 1.0566932769467638 0.2906515943000485 1.0 0.6737346855893396 22 Q8IUX1,O75306,Q8N183,Q9NPL8,O43676,Q9P032,Q9Y375 7 +Collagen biosynthesis and modifying enzymes 0.5057084508112548 1.0531067583657734 0.2922920657361734 1.0 0.6737346855893396 11 O75718,O15460,P13674 3 +G alpha i signalling events 0.4451063857126948 1.0492761164473867 0.2940510550390618 1.0 0.6737346855893396 18 P08754,P05067,Q14738,P04083,Q9ULM6,P10644,P04899 7 +Transport of vitamins nucleosides and related molecules 0.5749217456041295 1.0488973121489138 0.2942253827440217 1.0 0.6737346855893396 7 P12236,P12235,Q8TB61 3 +Anti inflammatory response favouring leishmania parasite infection 0.5271324743886833 1.044511346744622 0.2962488722708258 1.0 0.6737346855893396 9 P08754,P78536,P10644,P04899,Q9Y3E5 5 +Ptk6 regulates proteins involved in rna processing 0.7084013050570973 1.039975017343152 0.2983515076054592 1.0 0.6737346855893396 2 P23246 1 +Hcmv early events 0.3865567467244188 1.0318080775730687 0.3021620344955302 1.0 0.6761452656453462 38 Q9BUF5,Q9BVA1,Q13409,P83916,P37198,Q9BTX1,P68371 7 +Ros and rns production in phagocytes 0.5333860978498643 1.0278581921675511 0.3040165381918593 1.0 0.6779928888948742 8 Q93050,Q9Y487 2 +Class i peroxisomal membrane protein import 0.6068431741448876 1.0222256845722146 0.3066740970222601 1.0 0.6827642903299642 6 P51648,Q9NR77 2 +L1cam interactions 0.4080661732426648 1.0163787988318729 0.3094490376188084 1.0 0.6851700337149833 27 Q9BUF5,P68371 2 +Intra golgi and retrograde golgi to er traffic 0.3436787094275522 1.0123020295001943 0.3113936647915591 1.0 0.6851700337149833 66 Q9BUF5,P18085,Q9BVA1,O95721,Q9NSK0,Q13409,O00461,P62820,P61923,Q10472,P61163,O75935,P24390,P68371 14 +Hcmv infection 0.3751941179366644 0.9909512716228508 0.321709374753214 1.0 0.7023791787273223 42 Q9BUF5,Q9BVA1,Q13409,Q8NFH4,Q99816,P83916,P37198,Q9BTX1,P68371 9 +Tcf dependent signaling in response to wnt 0.3430654678213638 0.9868685144728504 0.3237071012372836 1.0 0.7040362366843892 54 P28070,P28072,P49721,P20618,P60900,Q14738,P31751,Q99436,P28074 9 +Hiv transcription initiation 0.5244753567307675 0.984286449498122 0.3249746901593582 1.0 0.7053827522750429 8 P18074,Q92804,P19388 3 +Glycerophospholipid biosynthesis 0.4327143167933848 0.9674226563744496 0.3333327885222772 1.0 0.7162103273071841 18 P35790,P40939,Q9UG56 3 +Collagen formation 0.4625370091997353 0.9665880591242884 0.333750006259804 1.0 0.7162103273071841 13 O75718,O15460,P13674 3 +Pyruvate metabolism 0.4479928597133632 0.954513606396052 0.3398237252558784 1.0 0.7229775386159452 15 P21796 1 +Mapk family signaling cascades 0.3350032762504415 0.9539762677015108 0.3400956554946024 1.0 0.7229775386159452 76 P28070,P04792,P28072,P49721,P20618,P60900,Q14738,Q99436,P62993,O60725,Q14168 11 +Hdr through single strand annealing ssa 0.472822792394591 0.9469766445656695 0.3436506802017334 1.0 0.7281858464724833 12 Q9UQ84,P35250 2 +Regulation of cholesterol biosynthesis by srebp srebf 0.4244299452022591 0.934766378063634 0.3499087102602642 1.0 0.7349836967695952 19 P48449,Q16850 2 +Regulation of beta cell development 0.7330245362756858 0.9285445919641232 0.3531251480890138 1.0 0.7370402442080761 3 P31751 1 +Transcriptional regulation by runx1 0.3368050539582568 0.9207491325642828 0.3571814179836861 1.0 0.7370402442080761 59 P28070,P28072,P49721,P20618,P60900,O96019,Q03164,Q969G3,Q96J02,Q99436,P28074 11 +Signalling to erks 0.6022133439958711 0.919851279241766 0.3576504819391426 1.0 0.7370402442080761 5 P11233 1 +Copi dependent golgi to er retrograde traffic 0.3756504170624443 0.914243992064491 0.3605886529701143 1.0 0.7370402442080761 36 Q9BUF5,P24390,Q9BVA1,P68371 4 +Formation of atp by chemiosmotic coupling 0.500839838204431 0.9127283062219252 0.3613854527866666 1.0 0.7370402442080761 9 P24539,O75947,P56134,O75964 4 +Tysnd1 cleaves peroxisomal proteins 0.6241626868413859 0.9039318016149208 0.3660315649628665 1.0 0.7388016284278744 4 Q15067 1 +Chondroitin sulfate dermatan sulfate metabolism 0.7263100888632706 0.9032967884469558 0.366368400564657 1.0 0.7388016284278744 3 Q8NCH0 1 +Diseases associated with glycosaminoglycan metabolism 0.7263100888632706 0.9032967884469558 0.366368400564657 1.0 0.7388016284278744 3 Q8NCH0 1 +Fatty acid metabolism 0.3632481774725895 0.8979319202518906 0.3692218458077332 1.0 0.7394053582892388 43 O43772,Q9H7Z7,P23786,Q15165,P50897,Q16836,P16219,P40939,Q14914 9 +Perk regulates gene expression 0.4761573607739074 0.8949138009164278 0.3708331686795267 1.0 0.7400718221700635 11 Q15024,Q92945,Q9NQT5,Q9Y2L1,Q9Y3B2 5 +Asparagine n linked glycosylation 0.3216578008411496 0.8922903131578502 0.3722373450384366 1.0 0.7400718221700635 90 Q99519,Q9BUF5,O75340,Q9BVA1,Q9BUN8,Q13409,P62820,P10619,P61923,P16278,P61163,O75935,P24390,P68371 14 +Signaling by retinoic acid 0.4957422167631187 0.8872762553431873 0.3749301861539424 1.0 0.7428532459205526 9 O94788,Q15120 2 +Formation of the cornified envelope 0.6195918367346903 0.8854098985388368 0.3759355956214025 1.0 0.7428532459205526 4 Q14126,P15924,P14923 3 +Keratinization 0.6195918367346903 0.8854098985388368 0.3759355956214025 1.0 0.7428532459205526 4 Q14126,P15924,P14923 3 +Anchoring of the basal body to the plasma membrane 0.3928863622513057 0.8777440355465498 0.3800826414076823 1.0 0.747684957276605 25 P61163,O75935,P07437,P68371 4 +Mhc class ii antigen presentation 0.3599274186269269 0.8668961292274967 0.3859989245699613 1.0 0.7498338673409787 43 Q9BUF5,Q9BVA1,Q9NSK0,P10619,P61163,O75935,P68371 7 +Circadian clock 0.5694366812265123 0.8621131846768633 0.3886252366921368 1.0 0.753247149941524 6 P43490,P63208 2 +Synthesis secretion and deacylation of ghrelin 0.7118221144698362 0.849215290346684 0.3957615065785496 1.0 0.7592629776863586 3 P67812 1 +Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip 0.7118221144698362 0.849215290346684 0.3957615065785496 1.0 0.7592629776863586 3 P67812 1 +Rhog gtpase cycle 0.3804958974560218 0.8458874323496358 0.3976155441188584 1.0 0.7606056417251894 30 Q14739 1 +Fcgr3a mediated il10 synthesis 0.6073108987148642 0.8359140397303763 0.4032032634798488 1.0 0.7657376098940069 4 P10644 1 +Cargo recognition for clathrin mediated endocytosis 0.3949976260934871 0.8323303271751353 0.4052225169336174 1.0 0.7684651472208746 23 Q14108,Q8NC96,Q99627,P51809,P62993,Q9NVZ3 6 +Platelet homeostasis 0.5616568572583582 0.8291417823052145 0.4070241832695651 1.0 0.7706383627644703 6 P30626 1 +Separation of sister chromatids 0.3164592848870311 0.8165518090540048 0.414184604522672 1.0 0.7743195868948678 89 Q9BUF5,P28070,P28072,Q9BVA1,P49721,P20618,Q96DE5,P60900,Q13409,Q8NFH4,Q14738,Q16763,Q99436,P68371 14 +Golgi to er retrograde transport 0.3256491250404781 0.7964283233576072 0.4257831211273661 1.0 0.7848082961015235 55 Q9BUF5,P18085,Q9BVA1,Q9NSK0,Q13409,P62820,P61923,P61163,O75935,P24390,P68371 11 +Homologous dna pairing and strand exchange 0.4325319534995443 0.7923933004567556 0.4281313845955958 1.0 0.7848082961015235 13 Q9UQ84,P35250 2 +Regulation of plk1 activity at g2 m transition 0.3800332106004766 0.7909423465858779 0.4289776356788837 1.0 0.7849311400930012 26 P63208,Q13409,P07437,P61163,O75935,P68371 6 +Signaling by notch3 0.6943652711187154 0.7848882536087521 0.4325190896766591 1.0 0.7884649518586954 3 Q13573 1 +Beta oxidation of decanoyl coa to octanoyl coa coa 0.5665092123475332 0.7719685527141887 0.4401330531819569 1.0 0.7960494142983977 5 Q16836 1 +Beta oxidation of octanoyl coa to hexanoyl coa 0.5665092123475332 0.7719685527141887 0.4401330531819569 1.0 0.7960494142983977 5 Q16836 1 +Interleukin 3 interleukin 5 and gm csf signaling 0.5909937586710283 0.7708617734530661 0.4407888673443767 1.0 0.7960494142983977 4 P62993 1 +Suppression of apoptosis 0.642332789559546 0.7685507758116781 0.4421600367997103 1.0 0.7972187804405172 2 P23246 1 +Notch3 activation and transmission of signal to the nucleus 0.6398858075040726 0.7588305185500082 0.4479539469372793 1.0 0.8010899620940761 2 Q92542 1 +Noncanonical activation of notch3 0.6398858075040726 0.7588305185500082 0.4479539469372793 1.0 0.8010899620940761 2 Q92542 1 +Er to golgi anterograde transport 0.3197283755683071 0.7306689382066952 0.4649813927488631 1.0 0.8161724748684904 57 Q9BUF5,Q9BVA1,Q13409,P62820,P61923,P61163,O75935,P24390,P68371 9 +Transport to the golgi and subsequent modification 0.3197283755683071 0.7306689382066952 0.4649813927488631 1.0 0.8161724748684904 57 Q9BUF5,Q9BVA1,Q13409,P62820,P61923,P61163,O75935,P24390,P68371 9 +Aurka activation by tpx2 0.3762186821513884 0.7241321161385859 0.4689846292953783 1.0 0.8163218067884455 24 P61163,O75935,P07437,P68371 4 +Signal amplification 0.6771062613093392 0.7223634154826346 0.470071073432708 1.0 0.8163218067884455 3 P04899 1 +Recruitment of mitotic centrosome proteins and complexes 0.3720796118122752 0.7223207350234929 0.4700973075511609 1.0 0.8163218067884455 25 P61163,O75935,P07437,P68371 4 +Attenuation phase 0.4523739340403859 0.7124968505973204 0.4761571609893211 1.0 0.8225100107259833 10 P04792 1 +Hsf1 activation 0.4181419413913793 0.7096355286807532 0.4779301815832348 1.0 0.8234143520610504 13 P35244,P04792 2 +Disorders of transmembrane transporters 0.3148638286974781 0.6974270130316855 0.4855356011846283 1.0 0.8277676889765694 72 P28070,P28072,Q9BUN8,P49721,P20618,P60900,Q8NFH4,Q99436,P28074,P37198,Q9BTX1 11 +Triglyceride catabolism 0.5718929079301444 0.6959817174424593 0.4864402793444471 1.0 0.8277676889765694 4 P62136,P17612 2 +Triglyceride metabolism 0.5718929079301444 0.6959817174424593 0.4864402793444471 1.0 0.8277676889765694 4 P62136,P17612 2 +Regulation of glycolysis by fructose 2 6 bisphosphate metabolism 0.6694408684347481 0.6949877299939304 0.4870629910781572 1.0 0.8277676889765694 3 Q14738 1 +Interleukin 4 and interleukin 13 signaling 0.4372316231370312 0.689036998738002 0.4907999846651065 1.0 0.8314580717077255 11 P09601 1 +Neurotransmitter receptors and postsynaptic signal transmission 0.3710504039414331 0.686449016204873 0.4924300040471283 1.0 0.8331485819436651 24 Q9BUF5,Q9BVA1,P68371 3 +Hdr through homologous recombination hrr 0.3863818512340429 0.6802453562638934 0.4963491177619386 1.0 0.838399456809382 19 P41440,Q9UQ84,P35250 3 +Metabolism of vitamins and cofactors 0.3515482898794536 0.6795242497667077 0.4968057479272589 1.0 0.838399456809382 34 P41440,Q9NRN7,Q9NVE7,O75874,P35270,P43490,P00374,Q9H2D1 8 +Activation of atr in response to replication stress 0.4073258214227673 0.6749645390528759 0.4996982947716673 1.0 0.8422024968146515 14 Q9Y619,P35250 2 +Protein folding 0.3607038936321509 0.6642305516377401 0.5065427622875203 1.0 0.8441157772570679 28 Q9BUF5,Q9BVA1,P68371 3 +Activation of bh3 only proteins 0.4423049604817888 0.6621282645613219 0.5078890230133517 1.0 0.8441157772570679 10 P61981,P31751,P27348 3 +Cd28 co stimulation 0.5211046068085311 0.6603332117595745 0.50904002167248 1.0 0.8441157772570679 6 P31751 1 +Proton coupled monocarboxylate transport 0.6146003262642801 0.6603194848950628 0.5090488286827877 1.0 0.8441157772570679 2 P53985 1 +Signaling by vegf 0.3857313309152291 0.6584537101384801 0.5102466323575783 1.0 0.8441157772570679 18 Q9UQB8,P04792 2 +Sulfur amino acid metabolism 0.4483720191231903 0.6541703260530172 0.5130020770735291 1.0 0.8441157772570679 9 Q13126 1 +Plasma lipoprotein assembly remodeling and clearance 0.4187575863762063 0.6487020126736721 0.5165310032222723 1.0 0.8478055569700559 12 P61916,Q8WTV0,P07237 3 +Processing of dna double strand break ends 0.3677840788614574 0.6374266088380364 0.5238470007195555 1.0 0.8555518549546148 23 Q9NXR7,Q9UNS1,O96028,P35250,Q9UQ84 5 +Transcription of the hiv genome 0.38970535692694 0.6317856905266604 0.5275269252586283 1.0 0.8604956528352378 16 Q92804,P18074,O00267,P29083,P19388 5 +Prevention of phagosomal lysosomal fusion 0.6446348429212578 0.6083375615822774 0.5429636136457847 1.0 0.8764451809830109 3 Q9H267,P51149 2 +Translesion synthesis by polh 0.4092553604384739 0.597497070075297 0.5501755625671594 1.0 0.8834151785406787 12 P41440,P35250 2 +Esr mediated signaling 0.3502234462863768 0.5942126591727478 0.5523698868470008 1.0 0.8834151785406787 29 P04792,Q08752,P31751,Q15185,P19388 5 +Mitochondrial fatty acid beta oxidation 0.396924157534946 0.5893475625017025 0.5556281449973781 1.0 0.8834151785406787 13 Q16836,P40939 2 +Stimuli sensing channels 0.5013970631190727 0.5808677963679876 0.5613295580583941 1.0 0.8834151785406787 6 Q9C0H2 1 +Pyruvate metabolism and citric acid tca cycle 0.3397178567502414 0.5808255236329881 0.5613580510896963 1.0 0.8834151785406787 34 P48735,P21796 2 +Rac1 gtpase cycle 0.3469603942288164 0.5803393048712278 0.5616858267200977 1.0 0.8834151785406787 30 Q14739 1 +Peroxisomal lipid metabolism 0.468604911612058 0.5730859129158123 0.566586524911727 1.0 0.8868516438705778 7 P51648,Q15067 2 +Synthesis of pips at the plasma membrane 0.5394383937592495 0.5728559055365088 0.5667422624598775 1.0 0.8868516438705778 4 Q9Y217 1 +Ddx58 ifih1 mediated induction of interferon alpha beta 0.4234185235431245 0.5691213329210625 0.569273802019268 1.0 0.8868516438705778 10 P05067 1 +Transcriptional regulation by mecp2 0.3912438343450101 0.557621874645769 0.577102616036516 1.0 0.8924983038765686 13 Q14739 1 +Pten regulation 0.3035930019094658 0.5539180214096752 0.5796349511014678 1.0 0.8924983038765686 56 P28070,O75832,P28072,Q9Y2Q5,P49721,P20618,P60900,P31751,Q6IAA8,Q99436,P28074 11 +Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0.5334569691471595 0.5508522989993305 0.5817349292326077 1.0 0.8924983038765686 4 P12235 1 +Darpp 32 events 0.4631489103709634 0.549942913551405 0.5823585290848627 1.0 0.8924983038765686 7 P10644,P62136,P17612,Q14738 4 +Striated muscle contraction 0.6258771479888539 0.5450986266647466 0.5856856871806364 1.0 0.8934418237315725 3 Q9NYL9 1 +Dual incision in gg ner 0.3653360249721198 0.5419016834228149 0.5878862370162352 1.0 0.895445551452891 19 P18074,P41440,P35250 3 +Hemostasis 0.2931147582825972 0.5398039961934251 0.5893322108659014 1.0 0.8958937184789596 92 Q8IWA4,P60903,Q9BUF5,P07737,Q9BVA1,P05067,P42785,Q9NSK0,P30626,Q9NTK5,Q8NBX0,O15439,O43852,Q08380,P68371 15 +Erks are inactivated 0.528453608382613 0.5326356844168353 0.5942857952558636 1.0 0.9003088254565841 4 Q8IV63,Q14738 2 +Alpha oxidation of phytanate 0.6172641658364153 0.5168180055316896 0.6052832096839913 1.0 0.904025871273002 3 P51648 1 +Pka mediated phosphorylation of creb 0.6167029179526213 0.5149928797065978 0.6065579956089922 1.0 0.904025871273002 3 P10644 1 +Glucagon signaling in metabolic regulation 0.6167029179526213 0.5149928797065978 0.6065579956089922 1.0 0.904025871273002 3 P10644 1 +Creb1 phosphorylation through the activation of adenylate cyclase 0.6167029179526213 0.5149928797065978 0.6065579956089922 1.0 0.904025871273002 3 P10644 1 +Pka activation in glucagon signalling 0.6167029179526213 0.5149928797065978 0.6065579956089922 1.0 0.904025871273002 3 P10644 1 +Vasopressin regulates renal water homeostasis via aquaporins 0.6167029179526213 0.5149928797065978 0.6065579956089922 1.0 0.904025871273002 3 P10644 1 +Unfolded protein response upr 0.3314411225020697 0.5123589590424148 0.6083998086640006 1.0 0.904025871273002 34 Q15024,P61421,Q9Y2L1,Q9NQT5,Q8N6T3,Q13217,Q9Y5M8,Q9NWM8,P43307,Q9Y3B2 10 +Carnitine metabolism 0.521969022072788 0.5092963630748135 0.6105445068155979 1.0 0.9051717210157008 4 O43772 1 +Plasma lipoprotein clearance 0.4068011854779956 0.4893306538397944 0.6246076223842505 1.0 0.913084326530485 10 Q8WTV0 1 +Foxo mediated transcription 0.4065456143701359 0.4881212938637951 0.6254639290919959 1.0 0.913084326530485 10 P61981,P31751,P27348 3 +Phospholipid metabolism 0.3387669199002671 0.4827117870102594 0.6293003928294185 1.0 0.913084326530485 26 Q9UG56,P48651,Q8IV08,Q9Y217,P61106,P35790,P40939,Q9NPH0 8 +Degradation of the extracellular matrix 0.4463621894938691 0.4800895285233626 0.6311637337958071 1.0 0.913084326530485 7 P17655,P07384,Q92542,P35613,P78536 5 +Signaling by notch1 0.4161541458011404 0.4729983954171559 0.63621432395382 1.0 0.913084326530485 8 Q92542,P63208,Q13573,Q96J02 4 +Endosomal sorting complex required for transport escrt 0.5109043166892854 0.4702251894242585 0.6381941393495822 1.0 0.9132897672776866 4 Q8WUX9,Q99816 2 +Antigen processing ubiquitination proteasome degradation 0.2919864789585938 0.4533604943145455 0.6502891787242344 1.0 0.9215926210306892 80 P28070,P28072,P20618,P55786,P49721,P60900,Q9UIQ6,P63208,Q16763,Q96J02,Q99436,P28074 12 +Dap12 interactions 0.5046687600089255 0.4486538123581602 0.6536814082343039 1.0 0.923990181621134 4 P62993 1 +Signaling by wnt 0.2937704904672593 0.4480957478490819 0.6540840967014552 1.0 0.923990181621134 71 P28070,P07737,P28072,P49721,P20618,P60900,P63208,Q14738,P31751,Q99436,P28074 11 +Golgi cisternae pericentriolar stack reorganization 0.4371675892891046 0.4428054750643019 0.6579064428139059 1.0 0.9255439524942154 7 P62820 1 +Recognition of dna damage by pcna containing replication complex 0.3589143230324298 0.4204922753636579 0.6741258712551637 1.0 0.9390965262278708 15 P41440,P35250 2 +Regulation of tp53 activity through phosphorylation 0.341351619009193 0.4167425903334518 0.6768666983414144 1.0 0.9390965262278708 21 Q92804,Q9UQ84,P35250 3 +Ra biosynthesis pathway 0.5849016521318513 0.4154821746398324 0.6777889615848565 1.0 0.9390965262278708 3 O94788 1 +Neuronal system 0.3159202602602184 0.4137897860323088 0.679028064867345 1.0 0.9390965262278708 38 O95197,P41440,P21964,Q9BUF5,Q9BVA1,Q9Y639,P04899,Q14168,P68371 9 +Depolymerisation of the nuclear lamina 0.4290968532897489 0.4107229352179375 0.6812757074150775 1.0 0.9411665019148522 7 Q9Y2U8,P06493,P42166,P50402,P20700,P42167 6 +Neddylation 0.2907604300898361 0.4077912347412318 0.6834269492877314 1.0 0.9411665019148522 63 P28070,P61962,O75832,P28072,P49721,Q99627,P20618,P60900,P63208,Q9UL46,Q99436,P28074 12 +Polymerase switching 0.3811720132956279 0.4068615527991668 0.6841096753859639 1.0 0.9411665019148522 11 P35250 1 +Metabolism of water soluble vitamins and cofactors 0.3255881388004856 0.4061337415397437 0.6846443349502431 1.0 0.9411665019148522 29 P41440,Q96EY8,Q9NRN7,Q9NVE7,Q4G0N4,Q8NFF5,P43490,P00374,P78417,Q9H2D1 10 +Dual incision in tc ner 0.3260582626115326 0.386603025235767 0.6990501179677162 1.0 0.949134381019734 25 P18074,P41440,P35244,P35250 4 +Vitamin b5 pantothenate metabolism 0.572696986872482 0.3795371997691191 0.7042889855514922 1.0 0.9508569303807004 3 Q9NRN7 1 +Intrinsic pathway for apoptosis 0.3535077250103671 0.3705194213658855 0.7109955084899457 1.0 0.9508569303807004 14 Q9NR28,P31751,Q07021,P61981,P27348 5 +Formation of the early elongation complex 0.3858913912915844 0.3669233072689622 0.7136762255125217 1.0 0.9508569303807004 9 P18074,O00267,P19388 3 +Ire1alpha activates chaperones 0.3328784766615665 0.3617175645349459 0.717563100020175 1.0 0.9508569303807004 21 P61421,Q8N6T3,Q13217,Q9Y5M8,Q9NWM8,P43307 6 +Transcriptional regulation by e2f6 0.4566054933568634 0.3566107468683953 0.7213832309615862 1.0 0.9508569303807004 5 Q13185 1 +Lagging strand synthesis 0.3507474238181942 0.3557315977284326 0.7220415793260992 1.0 0.9508569303807004 14 P41440,P35250 2 +Polymerase switching on the c strand of the telomere 0.3620792941494059 0.3544017133814709 0.7230378506940673 1.0 0.9508569303807004 12 P35250 1 +Adaptive immune system 0.2988003496523767 0.3457939806470922 0.7294975491736753 1.0 0.9541327530851432 153 P28070,P49721,Q9UIQ6,Q13409,P31751,Q99436,P61163,P62993,P28074,P68371,Q9BUF5,P28072,Q9BVA1,P55786,P63208,P10619,Q96J02,Q9NZ08,P20618,Q9NSK0,P60900,Q14738,Q16763,O75935 24 +Pcna dependent long patch base excision repair 0.3481299565745807 0.341809533326411 0.732494234698092 1.0 0.9558687141901836 14 P41440,P35250 2 +Transmission across chemical synapses 0.3152236079612881 0.3367468932634806 0.7363077100840338 1.0 0.9565966099271654 30 Q9BUF5,Q9BVA1,P68371 3 +Late endosomal microautophagy 0.4063743565600679 0.3240981731655792 0.745863709952745 1.0 0.9565966099271654 7 P08670,Q8WUX9,Q99816 3 +Factors involved in megakaryocyte development and platelet production 0.3060747662277348 0.3231548246668813 0.7465779915917539 1.0 0.9565966099271654 36 Q9NSK0,Q9BUF5,Q9BVA1,P68371 4 +Gap filling dna repair synthesis and ligation in gg ner 0.3444670670847325 0.3224985991478855 0.7470749988336174 1.0 0.9565966099271654 14 P41440,P35250 2 +Ikk complex recruitment mediated by rip1 0.5126427406199049 0.3160867813894278 0.7519366397127476 1.0 0.9565966099271654 2 Q13546 1 +Ticam1 rip1 mediated ikk complex recruitment 0.5126427406199049 0.3160867813894278 0.7519366397127476 1.0 0.9565966099271654 2 Q13546 1 +Tgf beta receptor signaling in emt epithelial to mesenchymal transition 0.5114192495921792 0.3126481663434963 0.7545479798091261 1.0 0.9565966099271654 2 Q9Y624 1 +Apoptosis 0.2805171053553541 0.3119275015102766 0.7550956213484787 1.0 0.9565966099271654 79 P26583,P28070,Q9NR28,O75832,P28072,P49721,P20618,P60900,P08670,P61981,P48556,Q9UL46,P31751,Q07021,Q99436,P27348,P28074 17 +Diseases of metabolism 0.3080699779012198 0.3113275213469883 0.7555516471427763 1.0 0.9565966099271654 33 O43505,O75340,Q96EY8,Q8NCH0,O75874,P54802,P10619,P16278,P15586,P10253,Q99519 11 +Microrna mirna biogenesis 0.4010837646594071 0.3048048542927703 0.7605147841628144 1.0 0.960896556034346 7 Q8WYQ5 1 +Role of abl in robo slit signaling 0.4595918367346883 0.3039905948504864 0.7611350565249295 1.0 0.960896556034346 4 O75122,Q7Z460,O94813 3 +Rhoc gtpase cycle 0.3164528170071717 0.3011971631553092 0.7632641529208868 1.0 0.9626623478944772 24 Q14739 1 +Telomere c strand lagging strand synthesis 0.3333023327679217 0.2978414858910646 0.7658241495060338 1.0 0.9649677141959394 16 P41440,P35250 2 +Phase ii conjugation of compounds 0.3244106186887631 0.2957211007889531 0.7674430814413269 1.0 0.9651621959347984 20 P21964,Q8TB61,O14880,O60701,P78417,Q9NUJ1 6 +Energy dependent regulation of mtor by lkb1 ampk 0.4540129456917184 0.2876527830300363 0.7736125366307909 1.0 0.9701439802848548 4 Q9Y2Q5 1 +Cytokine signaling in immune system 0.2957688622893631 0.2709375086502372 0.7864390958410084 1.0 0.9771245606178678 158 P28070,P49721,P07237,P31751,P09601,Q99436,P37198,Q13501,P05067,Q8NFH4,P11233,P62993,P28074,P52597,P28072,Q13126,P63208,P04083,O75832,P20618,P60900,P51809,P22626,Q14738,O14979,Q00169,Q9BTX1 27 +Resolution of ap sites via the multiple nucleotide patch replacement pathway 0.323329091327045 0.2700676593297519 0.7871082020437135 1.0 0.9771245606178678 18 P41440,Q86W56,P35250 3 +Synthesis of ketone bodies 0.4955138662316529 0.2697765539809285 0.7873321614687809 1.0 0.9771245606178678 2 P35914 1 +Ketone body metabolism 0.4955138662316529 0.2697765539809285 0.7873321614687809 1.0 0.9771245606178678 2 P35914 1 +Homology directed repair 0.2974057557483629 0.2519706881336631 0.801063720436892 1.0 0.9844830539665828 35 P41440,Q9NXR7,Q9UNS1,O96028,P35250,Q9UQ84 6 +Programmed cell death 0.2718623688386705 0.2479170301839588 0.8041986029892767 1.0 0.985700308823184 89 P28070,Q9NR28,P49721,P08670,P48556,P31751,Q99436,P26583,P27348,P28074,P41440,P28072,Q9UL46,O75832,P20618,P60900,Q8WUX9,Q07021,P61981 19 +Synthesis of gdp mannose 0.4824632952691686 0.2372325989774024 0.8124763477121739 1.0 0.9886518806118616 2 Q96IJ6 1 +Pkmts methylate histone lysines 0.4048968353624237 0.2363966242057071 0.8131249154652944 1.0 0.9886518806118616 6 Q03164 1 +Termination of translesion dna synthesis 0.3252986779283069 0.2251141927789539 0.8218904400935279 1.0 0.9890855643071912 14 P41440,P35250 2 +P75ntr regulates axonogenesis 0.5104039167686737 0.2195983220575298 0.8261839983190935 1.0 0.9890855643071912 3 Q9NQC3,P61586 2 +Regulation of pyruvate dehydrogenase pdh complex 0.3523800987136013 0.2157563968091537 0.8291776380631695 1.0 0.9890855643071912 8 Q15120 1 +Glucagon like peptide 1 glp1 regulates insulin secretion 0.4235958306675175 0.205628190051488 0.8370813555860699 1.0 0.9890855643071912 4 P10644 1 +Class i mhc mediated antigen processing presentation 0.2622066246326555 0.1972384467795739 0.8436409453391889 1.0 0.9912206331995436 100 Q9NZ08,P28070,P28072,P55786,P49721,P20618,P60900,Q9UIQ6,P63208,Q16763,Q96J02,Q99436,P28074 13 +Formation of rna pol ii elongation complex 0.3102381352227599 0.1958513536343749 0.844726513951473 1.0 0.9912206331995436 18 Q9GZS3,P18074,O00267,Q7KZ85,P19388 5 +Mrna capping 0.345859153233704 0.1928198222510907 0.8471000788874847 1.0 0.9912206331995436 8 P18074,P19388 2 +Budding and maturation of hiv virion 0.3897754714840525 0.1921433404562645 0.8476299265763982 1.0 0.9912206331995436 6 Q8WUX9,Q99816 2 +Apc c cdc20 mediated degradation of cyclin b 0.3423678563665997 0.1808512110158537 0.8564843652255538 1.0 0.993066477303894 8 Q96DE5 1 +Signaling by receptor tyrosine kinases 0.2681433795344282 0.1715099564731179 0.8638228023046342 1.0 0.9934533351821664 81 P61421,P04792,P52597,Q9UQB8,P31943,Q01085,Q14738,P31751,P11233,Q93050,Q9Y487,P62993,P31483,P19388,Q15904 15 +Aryl hydrocarbon receptor signalling 0.4862911526477538 0.169690884785806 0.8652532429934299 1.0 0.9934533351821664 3 Q15185 1 +M phase 0.2895680078729793 0.1657250084673768 0.8683733642860583 1.0 0.9934533351821664 161 Q01105,P28070,P49721,Q86XL3,Q13409,Q99436,P37198,Q14739,Q8IXJ6,Q8NFH4,P07437,P62820,P61163,P28074,P68371,Q9BUF5,P28072,Q9BVA1,Q96DE5,O75832,P20618,P60900,Q9H8Y8,Q14738,Q16763,O75935,Q9BTX1 27 +Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1 0.4490212071778173 0.165268770305984 0.8687324384621011 1.0 0.9934533351821664 2 P06493 1 +Global genome nucleotide excision repair gg ner 0.2883028261941383 0.162507679167689 0.8709060815553813 1.0 0.9934533351821664 33 P41440,Q92905,Q99627,P35250,P35251,O96019,Q9BT78,P18074,P54727,P35244,P18887 11 +Rnd3 gtpase cycle 0.3099336177213739 0.1611395793474955 0.8719834677444611 1.0 0.9934533351821664 15 P38159,Q9Y2I1,Q9NYL9,Q03001 4 +Smooth muscle contraction 0.3331689585030885 0.1609816909516612 0.872107821057184 1.0 0.9934533351821664 9 P04083 1 +Signaling by egfr 0.3877960816327416 0.1570820771604524 0.8751801625742295 1.0 0.9943857364420986 5 P62993 1 +Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.3541309047001769 0.1512670644257627 0.8797650490648192 1.0 0.9967048043528944 7 Q96DE5 1 +Signaling by notch1 pest domain mutants in cancer 0.3501287423411828 0.1398381605246942 0.8887878617691587 1.0 1.0 7 Q92542,P63208,Q13573 3 +Ethanol oxidation 0.4671607446681854 0.1352683061927316 0.8923997427256196 1.0 1.0 3 P30837 1 +Ptk6 regulates cell cycle 0.4314845024469808 0.1342726010586785 0.8931870182115467 1.0 1.0 2 P24941 1 +Synthesis secretion and inactivation of glucagon like peptide 1 glp 1 0.3915484400662273 0.1333117099813531 0.8939468670362469 1.0 1.0 4 P67812 1 +Incretin synthesis secretion and inactivation 0.3915484400662273 0.1333117099813531 0.8939468670362469 1.0 1.0 4 P67812 1 +Regulation of insulin secretion 0.324022392533343 0.1302261372321517 0.8963875161379118 1.0 1.0 9 P04899,P29966,P10644 3 +Deactivation of the beta catenin transactivating complex 0.3651393466292935 0.1274614655085681 0.8985751704378333 1.0 1.0 6 P31751 1 +Integrin cell surface interactions 0.4622603019175798 0.1271959992500426 0.8987852717992109 1.0 1.0 3 P35613,Q9Y624 2 +Postmitotic nuclear pore complex npc reformation 0.2940392307594223 0.1261908495956187 0.8995808544285406 1.0 1.0 21 Q92973,Q8NFH4,Q8NFH5,P37198,Q9BTX1 5 +Intracellular signaling by second messengers 0.2645263099831829 0.1178855759003228 0.906158322313884 1.0 1.0 72 P28070,O75832,P28072,Q9Y2Q5,P49721,P20618,P60900,Q14738,P31751,Q6IAA8,P10644,Q99436,P62993,P28074 14 +Receptor mediated mitophagy 0.4168026101141943 0.1118653866188586 0.9109301417723524 1.0 1.0 2 P67870 1 +Synthesis of bile acids and bile salts 0.3662719477337714 0.1088430223008496 0.9133269996405884 1.0 1.0 5 Q9BZF3,P22307,P51659,Q96SU4 4 +Bile acid and bile salt metabolism 0.3662719477337714 0.1088430223008496 0.9133269996405884 1.0 1.0 5 Q9BZF3,P22307,P51659,Q96SU4 4 +Rho gtpases activate wasps and waves 0.3060838248635058 0.1075274628069524 0.9143705394519012 1.0 1.0 12 Q9UQB8 1 +Opioid signalling 0.2990154115759535 0.1003090667134931 0.9200989596030658 1.0 1.0 13 P04899,P08754,Q14738,P10644 4 +Phosphorylation of the apc c 0.3140504818472012 0.0986660563577279 0.9214034204229208 1.0 1.0 9 Q96DE5 1 +Abortive elongation of hiv 1 transcript in the absence of tat 0.3340235273210029 0.0967881209101611 0.9228946577811804 1.0 1.0 7 O00267,P19388 2 +Atf6 atf6 alpha activates chaperone genes 0.4045676998368692 0.0955903564513532 0.923845924562775 1.0 1.0 2 P27797 1 +Scavenging by class a receptors 0.4045676998368692 0.0955903564513532 0.923845924562775 1.0 1.0 2 P27797 1 +Atf6 atf6 alpha activates chaperones 0.4045676998368692 0.0955903564513532 0.923845924562775 1.0 1.0 2 P27797 1 +Trafficking and processing of endosomal tlr 0.4045676998368676 0.0955903564513513 0.9238459245627766 1.0 1.0 2 Q99538 1 +Aberrant regulation of mitotic exit in cancer due to rb1 defects 0.3144957581354698 0.0937271534817608 0.925325899861311 1.0 1.0 8 Q96DE5 1 +Cell surface interactions at the vascular wall 0.3076923076923082 0.0865955538730798 0.9309930001210645 1.0 1.0 10 P08195,P05026,P05556,P53985,P35613,P54709,Q9Y624,P62993,P14174 9 +Signaling by cytosolic fgfr1 fusion mutants 0.3536095576012641 0.0839594519759103 0.9330886705280972 1.0 1.0 5 P62993 1 +Formation of incision complex in gg ner 0.3021822419603273 0.0785352206146721 0.9374023147307337 1.0 1.0 11 P18074 1 +Dna strand elongation 0.2832765844658595 0.0738860642429724 0.941101044661121 1.0 1.0 22 P41440,Q9BRT9,P35250 3 +Muscle contraction 0.2806005834680576 0.066708984739611 0.9468133814596428 1.0 1.0 23 P04083,P30626,Q9NYL9 3 +Phosphorylation of emi1 0.3727569331158322 0.0627780329575628 0.9499432585186952 1.0 1.0 2 P06493 1 +Interaction between l1 and ankyrins 0.4104447164422667 0.0600191521692013 0.9521403809618952 1.0 1.0 3 Q12955,Q13813 2 +Resolution of abasic sites ap sites 0.2815415185361729 0.0583581163585941 0.9534633761865594 1.0 1.0 21 P41440,Q86W56,P35250 3 +Signaling by hippo 0.3372805226623173 0.0557369506472787 0.9555513628824104 1.0 1.0 5 P31946,P62258,Q4VCS5,Q9UDY2 4 +Signaling by fgfr1 in disease 0.3304902837338277 0.0534242269215696 0.9573939024813248 1.0 1.0 6 P62993 1 +Fgfr1 mutant receptor activation 0.3304902837338277 0.0534242269215696 0.9573939024813248 1.0 1.0 6 P62993 1 +Regulation of tp53 activity 0.2726614729605437 0.0526400372077881 0.9580187160975552 1.0 1.0 33 P31751,Q92804,Q9UQ84,P35250 4 +Detoxification of reactive oxygen species 0.2969325153374165 0.0495730964449351 0.9604625861905428 1.0 1.0 9 P04179,Q96HE7,P30044,P07237,P32119,P30041,Q16881,P30048 8 +Mastl facilitates mitotic progression 0.3875968992248083 0.0402123970970361 0.9679237941709172 1.0 1.0 3 P06493,P30153 2 +Runx1 regulates expression of components of tight junctions 0.3368678629690008 0.0398435193833161 0.9682178803095456 1.0 1.0 2 Q16625 1 +Signaling by fgfr2 in disease 0.3226800061560979 0.039574897535341 0.9684320406212544 1.0 1.0 6 P19388 1 +Rab geranylgeranylation 0.2825893219874971 0.0390543518805548 0.9688470551023214 1.0 1.0 15 Q969Q5,P62820,P61020 3 +Tp53 regulates metabolic genes 0.2685226266568311 0.0206375584802945 0.9835347795046412 1.0 1.0 32 P13073,P15954,Q9Y2Q5,Q04917,P31751,P00403,Q6IAA8,O75880,P20674,P61981,P27348 11 +G2 m dna damage checkpoint 0.2689711473098986 0.0177274803120487 0.9858562579714087 1.0 1.0 30 Q9NXR7,O96028,Q9UQ84,P35250 4 +Fcgamma receptor fcgr dependent phagocytosis 0.274104683431097 0.0146094935534563 0.9883437253013267 1.0 1.0 19 Q9UQB8,Q8IV08 2 +Activation of the pre replicative complex 0.2751866121649191 0.0110752171987164 0.991163435839444 1.0 1.0 13 Q9Y619 1 +G protein mediated events 0.2801297055824631 0.0079495159874298 0.9936572707324338 1.0 1.0 9 P04899,P08754,P10644 3 +Notch hlh transcription pathway 0.2851897184822499 0.0024344065971862 0.9980576264799148 1.0 1.0 3 Q13547,Q13573 2 +Aspartate and asparagine metabolism 0.2948142098815908 0.0020243022785833 0.9983848415686196 1.0 1.0 5 P00505,O75746,P08243,Q9UJS0 4 diff --git a/msigdb_reactome/selections.json b/msigdb_reactome/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..dbc5be1afa7f36c236caccbdb34336645c385ffd --- /dev/null +++ b/msigdb_reactome/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2 ltr circle formation", "Abacavir metabolism", "Abacavir transmembrane transport", "Abacavir transport and metabolism", "Abc family proteins mediated transport", "Abc transporter disorders", "Abc transporters in lipid homeostasis", "Aberrant regulation of mitotic exit in cancer due to rb1 defects", "Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects", "Abortive elongation of hiv 1 transcript in the absence of tat", "Acetylcholine regulates insulin secretion", "Activated notch1 transmits signal to the nucleus", "Activated ntrk2 signals through cdk5", "Activated ntrk2 signals through frs2 and frs3", "Activated ntrk2 signals through fyn", "Activated ntrk2 signals through pi3k", "Activated ntrk2 signals through ras", "Activated ntrk3 signals through ras", "Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3", "Activated tak1 mediates p38 mapk activation", "Activation of ampk downstream of nmdars", "Activation of anterior hox genes in hindbrain development during early embryogenesis", "Activation of atr in response to replication stress", "Activation of bad and translocation to mitochondria", "Activation of bh3 only proteins", "Activation of gene expression by srebf srebp", "Activation of kainate receptors upon glutamate binding", "Activation of nima kinases nek9 nek6 nek7", "Activation of nmda receptors and postsynaptic events", "Activation of noxa and translocation to mitochondria", "Activation of puma and translocation to mitochondria", "Activation of rac1", "Activation of rac1 downstream of nmdars", "Activation of smo", "Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s", "Activation of the pre replicative complex", "Activation of the tfap2 ap 2 family of transcription factors", "Acyl chain remodeling of cl", "Acyl chain remodelling of pc", "Acyl chain remodelling of pg", "Acyl chain remodelling of pi", "Adaptive immune system", "Adenylate cyclase inhibitory pathway", "Adherens junctions interactions", "Adora2b mediated anti inflammatory cytokines production", "Adp signalling through p2y purinoceptor 12", "Adrenaline noradrenaline inhibits insulin secretion", "Advanced glycosylation endproduct receptor signaling", "Aflatoxin activation and detoxification", "Aggrephagy", "Akt phosphorylates targets in the cytosol", "Akt phosphorylates targets in the nucleus", "Alk mutants bind tkis", "Alpha linolenic omega3 and linoleic omega6 acid metabolism", "Alpha oxidation of phytanate", "Amino acid transport across the plasma membrane", "Amino acids regulate mtorc1", "Amyloid fiber formation", "Anchoring of the basal body to the plasma membrane", "Androgen biosynthesis", "Anti inflammatory response favouring leishmania parasite infection", "Antigen activates b cell receptor bcr leading to generation of second messengers", "Antigen presentation folding assembly and peptide loading of class i mhc", "Antigen processing cross presentation", "Antigen processing ubiquitination proteasome degradation", "Antimicrobial peptides", "Antiviral mechanism by ifn stimulated genes", "Apc c cdc20 mediated degradation of cyclin b", "Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1", "Apc c mediated degradation of cell cycle proteins", "Apc cdc20 mediated degradation of nek2a", "Apex1 independent resolution of ap sites via the single nucleotide replacement pathway", "Apobec3g mediated resistance to hiv 1 infection", "Apoptosis", "Apoptosis induced dna fragmentation", "Apoptotic cleavage of cell adhesion proteins", "Apoptotic cleavage of cellular proteins", "Apoptotic execution phase", "Apoptotic factor mediated response", "Aquaporin mediated transport", "Arachidonate production from dag", "Arachidonic acid metabolism", "Arms mediated activation", "Aryl hydrocarbon receptor signalling", "Asparagine n linked glycosylation", "Aspartate and asparagine metabolism", "Assembly and cell surface presentation of nmda receptors", "Assembly of collagen fibrils and other multimeric structures", "Assembly of the hiv virion", "Assembly of the orc complex at the origin of replication", "Association of tric cct with target proteins during biosynthesis", "Asymmetric localization of pcp proteins", "Atf4 activates genes in response to endoplasmic reticulum stress", "Atf6 atf6 alpha activates chaperone genes", "Atf6 atf6 alpha activates chaperones", "Attachment and entry", "Attachment of gpi anchor to upar", "Attenuation phase", "Auf1 hnrnp d0 binds and destabilizes mrna", "Aurka activation by tpx2", "Autophagy", "B wich complex positively regulates rrna expression", "Base excision repair", "Base excision repair ap site formation", "Basigin interactions", "Bbsome mediated cargo targeting to cilium", "Beta catenin independent wnt signaling", "Beta catenin phosphorylation cascade", "Beta oxidation of butanoyl coa to acetyl coa", "Beta oxidation of decanoyl coa to octanoyl coa coa", "Beta oxidation of hexanoyl coa to butanoyl coa", "Beta oxidation of lauroyl coa to decanoyl coa coa", "Beta oxidation of octanoyl coa to hexanoyl coa", "Beta oxidation of pristanoyl coa", "Beta oxidation of very long chain fatty acids", "Bh3 only proteins associate with and inactivate anti apoptotic bcl 2 members", "Bile acid and bile salt metabolism", "Binding and uptake of ligands by scavenger receptors", "Binding of tcf lef ctnnb1 to target gene promoters", "Biological oxidations", "Biosynthesis of epa derived spms", "Biosynthesis of specialized proresolving mediators spms", "Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein", "Biotin transport and metabolism", "Bmal1 clock npas2 activates circadian gene expression", "Branched chain amino acid catabolism", "Budding and maturation of hiv virion", "Butyrate response factor 1 brf1 binds and destabilizes mrna", "C type lectin receptors clrs", "Ca dependent events", "Ca2 pathway", "Calnexin calreticulin cycle", "Camk iv mediated phosphorylation of creb", "Carboxyterminal post translational modifications of tubulin", "Cardiac conduction", "Cargo concentration in the er", "Cargo recognition for clathrin mediated endocytosis", "Cargo trafficking to the periciliary membrane", "Carnitine metabolism", "Caspase activation via death receptors in the presence of ligand", "Caspase activation via extrinsic apoptotic signalling pathway", "Caspase mediated cleavage of cytoskeletal proteins", "Cation coupled chloride cotransporters", "Cd163 mediating an anti inflammatory response", "Cd209 dc sign signaling", "Cd28 co stimulation", "Cd28 dependent pi3k akt signaling", "Cd28 dependent vav1 pathway", "Cdc42 gtpase cycle", "Cdc6 association with the orc origin complex", "Cdt1 association with the cdc6 orc origin complex", "Cell cell communication", "Cell cell junction organization", "Cell cycle", "Cell cycle checkpoints", "Cell cycle mitotic", "Cell death signalling via nrage nrif and nade", "Cell extracellular matrix interactions", "Cell junction organization", "Cell surface interactions at the vascular wall", "Cellular response to chemical stress", "Cellular response to heat stress", "Cellular response to hypoxia", "Cellular response to starvation", "Cellular responses to stimuli", "Cellular senescence", "Chaperone mediated autophagy", "Chemokine receptors bind chemokines", "Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex", "Chl1 interactions", "Cholesterol biosynthesis", "Choline catabolism", "Chondroitin sulfate dermatan sulfate metabolism", "Chrebp activates metabolic gene expression", "Chromatin modifying enzymes", "Chromosome maintenance", "Chylomicron assembly", "Cilium assembly", "Circadian clock", "Citric acid cycle tca cycle", "Class a 1 rhodopsin like receptors", "Class b 2 secretin family receptors", "Class i mhc mediated antigen processing presentation", "Class i peroxisomal membrane protein import", "Clathrin mediated endocytosis", "Clec7a dectin 1 induces nfat activation", "Clec7a dectin 1 signaling", "Cobalamin cbl vitamin b12 transport and metabolism", "Coenzyme a biosynthesis", "Cohesin loading onto chromatin", "Collagen biosynthesis and modifying enzymes", "Collagen degradation", "Collagen formation", "Competing endogenous rnas cernas regulate pten translation", "Complement cascade", "Complex i biogenesis", "Condensation of prometaphase chromosomes", "Condensation of prophase chromosomes", "Constitutive signaling by aberrant pi3k in cancer", "Constitutive signaling by akt1 e17k in cancer", "Constitutive signaling by egfrviii", "Constitutive signaling by ligand responsive egfr cancer variants", "Constitutive signaling by overexpressed erbb2", "Conversion from apc c cdc20 to apc c cdh1 in late anaphase", "Cooperation of pdcl phlp1 and tric cct in g protein beta folding", "Cooperation of prefoldin and tric cct in actin and tubulin folding", "Copi dependent golgi to er retrograde traffic", "Copi independent golgi to er retrograde traffic", "Copi mediated anterograde transport", "Copii mediated vesicle transport", "Costimulation by the cd28 family", "Creatine metabolism", "Creb phosphorylation", "Creb1 phosphorylation through nmda receptor mediated activation of ras signaling", "Creb1 phosphorylation through the activation of adenylate cyclase", "Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde", "Cristae formation", "Crmps in sema3a signaling", "Cross presentation of soluble exogenous antigens endosomes", "Cs ds degradation", "Ctla4 inhibitory signaling", "Cyclin a b1 b2 associated events during g2 m transition", "Cyclin a cdk2 associated events at s phase entry", "Cyclin d associated events in g1", "Cytochrome c mediated apoptotic response", "Cytochrome p450 arranged by substrate type", "Cytokine signaling in immune system", "Cytoprotection by hmox1", "Cytosolic iron sulfur cluster assembly", "Cytosolic sensors of pathogen associated dna", "Cytosolic sulfonation of small molecules", "Cytosolic trna aminoacylation", "Dag and ip3 signaling", "Dap12 interactions", "Dap12 signaling", "Darpp 32 events", "Dcc mediated attractive signaling", "Ddx58 ifih1 mediated induction of interferon alpha beta", "Deactivation of the beta catenin transactivating complex", "Deadenylation dependent mrna decay", "Deadenylation of mrna", "Death receptor signalling", "Dectin 1 mediated noncanonical nf kb signaling", "Defective cftr causes cystic fibrosis", "Defective chst14 causes eds musculocontractural type", "Defective factor ix causes hemophilia b", "Defective intrinsic pathway for apoptosis", "Defective ripk1 mediated regulated necrosis", "Defects in biotin btn metabolism", "Defects in cobalamin b12 metabolism", "Defects in vitamin and cofactor metabolism", "Defects of contact activation system cas and kallikrein kinin system kks", "Degradation of axin", "Degradation of beta catenin by the destruction complex", "Degradation of cysteine and homocysteine", "Degradation of dvl", "Degradation of gli1 by the proteasome", "Degradation of the extracellular matrix", "Depolymerisation of the nuclear lamina", "Deposition of new cenpa containing nucleosomes at the centromere", "Dermatan sulfate biosynthesis", "Detoxification of reactive oxygen species", "Deubiquitination", "Developmental biology", "Dex h box helicases activate type i ifn and inflammatory cytokines production", "Digestion", "Digestion and absorption", "Disassembly of the destruction complex and recruitment of axin to the membrane", "Diseases associated with glycosaminoglycan metabolism", "Diseases associated with glycosylation precursor biosynthesis", "Diseases associated with n glycosylation of proteins", "Diseases associated with o glycosylation of proteins", "Diseases of carbohydrate metabolism", "Diseases of dna repair", "Diseases of glycosylation", "Diseases of immune system", "Diseases of metabolism", "Diseases of mismatch repair mmr", "Diseases of mitotic cell cycle", "Diseases of programmed cell death", "Diseases of signal transduction by growth factor receptors and second messengers", "Disinhibition of snare formation", "Disorders of transmembrane transporters", "Displacement of dna glycosylase by apex1", "Dissolution of fibrin clot", "Dna damage bypass", "Dna damage recognition in gg ner", "Dna damage reversal", "Dna damage telomere stress induced senescence", "Dna double strand break repair", "Dna double strand break response", "Dna methylation", "Dna repair", "Dna replication", "Dna replication initiation", "Dna replication pre initiation", "Dna strand elongation", "Dopamine clearance from the synaptic cleft", "Downregulation of erbb2 erbb3 signaling", "Downregulation of erbb2 signaling", "Downregulation of erbb4 signaling", "Downregulation of smad2 3 smad4 transcriptional activity", "Downregulation of tgf beta receptor signaling", "Downstream signal transduction", "Downstream signaling events of b cell receptor bcr", "Downstream signaling of activated fgfr1", "Downstream signaling of activated fgfr2", "Downstream signaling of activated fgfr3", "Downstream signaling of activated fgfr4", "Dscam interactions", "Dual incision in gg ner", "Dual incision in tc ner", "E2f enabled inhibition of pre replication complex formation", "E2f mediated regulation of dna replication", "E3 ubiquitin ligases ubiquitinate target proteins", "Early phase of hiv life cycle", "Ecm proteoglycans", "Effects of pip2 hydrolysis", "Egfr downregulation", "Egfr transactivation by gastrin", "Egr2 and sox10 mediated initiation of schwann cell myelination", "Elastic fibre formation", "Endogenous sterols", "Endosomal sorting complex required for transport escrt", "Endosomal vacuolar pathway", "Energy dependent regulation of mtor by lkb1 ampk", "Enos activation", "Eph ephrin mediated repulsion of cells", "Eph ephrin signaling", "Epha mediated growth cone collapse", "Ephb mediated forward signaling", "Ephrin signaling", "Epigenetic regulation of gene expression", "Er quality control compartment erqc", "Er to golgi anterograde transport", "Erbb2 regulates cell motility", "Ercc6 csb and ehmt2 g9a positively regulate rrna expression", "Erk mapk targets", "Erks are inactivated", "Erythrocytes take up carbon dioxide and release oxygen", "Erythropoietin activates ras", "Esr mediated signaling", "Establishment of sister chromatid cohesion", "Estrogen dependent gene expression", "Estrogen dependent nuclear events downstream of esr membrane signaling", "Ethanol oxidation", "Eukaryotic translation elongation", "Eukaryotic translation initiation", "Export of viral ribonucleoproteins from nucleus", "Extension of telomeres", "Extra nuclear estrogen signaling", "Extracellular matrix organization", "Factors involved in megakaryocyte development and platelet production", "Fanconi anemia pathway", "Fasl cd95l signaling", "Fatty acid metabolism", "Fatty acyl coa biosynthesis", "Fbxw7 mutants and notch1 in cancer", "Fc epsilon receptor fceri signaling", "Fceri mediated ca 2 mobilization", "Fceri mediated mapk activation", "Fceri mediated nf kb activation", "Fcgamma receptor fcgr dependent phagocytosis", "Fcgr3a mediated il10 synthesis", "Fgfr1 mutant receptor activation", "Fgfr2 alternative splicing", "Fgfr2 mutant receptor activation", "Fibronectin matrix formation", "Flt3 signaling", "Flt3 signaling in disease", "Folding of actin by cct tric", "Formation of apoptosome", "Formation of atp by chemiosmotic coupling", "Formation of fibrin clot clotting cascade", "Formation of incision complex in gg ner", "Formation of rna pol ii elongation complex", "Formation of senescence associated heterochromatin foci sahf", "Formation of tc ner pre incision complex", "Formation of the beta catenin tcf transactivating complex", "Formation of the cornified envelope", "Formation of the early elongation complex", "Formation of tubulin folding intermediates by cct tric", "Formation of xylulose 5 phosphate", "Formyl peptide receptors bind formyl peptides and many other ligands", "Foxo mediated transcription", "Foxo mediated transcription of oxidative stress metabolic and neuronal genes", "Free fatty acids regulate insulin secretion", "Frs mediated fgfr1 signaling", "Frs mediated fgfr2 signaling", "Frs mediated fgfr3 signaling", "Frs mediated fgfr4 signaling", "Fructose metabolism", "G alpha 12 13 signalling events", "G alpha i signalling events", "G alpha q signalling events", "G alpha s signalling events", "G alpha z signalling events", "G beta gamma signalling through cdc42", "G beta gamma signalling through pi3kgamma", "G protein beta gamma signalling", "G protein mediated events", "G0 and early g1", "G1 s dna damage checkpoints", "G1 s specific transcription", "G2 m checkpoints", "G2 m dna damage checkpoint", "G2 m dna replication checkpoint", "G2 phase", "Gab1 signalosome", "Gaba b receptor activation", "Gaba receptor activation", "Gaba synthesis release reuptake and degradation", "Galactose catabolism", "Gamma carboxylation hypusine formation and arylsulfatase activation", "Gamma carboxylation transport and amino terminal cleavage of proteins", "Gap filling dna repair synthesis and ligation in gg ner", "Gap junction assembly", "Gap junction degradation", "Gap junction trafficking and regulation", "Gastrin creb signalling pathway via pkc and mapk", "Gdp fucose biosynthesis", "Gene and protein expression by jak stat signaling after interleukin 12 stimulation", "Gene silencing by rna", "Generation of second messenger molecules", "Global genome nucleotide excision repair gg ner", "Glucagon like peptide 1 glp1 regulates insulin secretion", "Glucagon signaling in metabolic regulation", "Gluconeogenesis", "Glucose metabolism", "Glucuronidation", "Glutamate and glutamine metabolism", "Glutamate neurotransmitter release cycle", "Glutathione conjugation", "Glutathione synthesis and recycling", "Glycerophospholipid biosynthesis", "Glycerophospholipid catabolism", "Glycogen breakdown glycogenolysis", "Glycogen metabolism", "Glycogen storage diseases", "Glycogen synthesis", "Glycolysis", "Glycosaminoglycan metabolism", "Glycosphingolipid metabolism", "Glyoxylate metabolism and glycine degradation", "Golgi associated vesicle biogenesis", "Golgi cisternae pericentriolar stack reorganization", "Golgi to er retrograde transport", "Gp1b ix v activation signalling", "Gpcr ligand binding", "Gpvi mediated activation cascade", "Grb2 events in erbb2 signaling", "Grb2 sos provides linkage to mapk signaling for integrins", "Growth hormone receptor signaling", "Hats acetylate histones", "Hcmv early events", "Hcmv infection", "Hcmv late events", "Hdacs deacetylate histones", "Hdl assembly", "Hdl clearance", "Hdms demethylate histones", "Hdr through homologous recombination hrr", "Hdr through mmej alt nhej", "Hdr through single strand annealing ssa", "Hedgehog ligand biogenesis", "Hedgehog off state", "Hedgehog on state", "Heme biosynthesis", "Heme degradation", "Heme signaling", "Hemostasis", "Heparan sulfate heparin hs gag metabolism", "Hiv elongation arrest and recovery", "Hiv infection", "Hiv life cycle", "Hiv transcription elongation", "Hiv transcription initiation", "Homologous dna pairing and strand exchange", "Homology directed repair", "Host interactions of hiv factors", "Hs gag degradation", "Hsf1 activation", "Hsf1 dependent transactivation", "Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand", "Hur elavl1 binds and stabilizes mrna", "Hyaluronan metabolism", "Hyaluronan uptake and degradation", "Ikk complex recruitment mediated by rip1", "Immunoregulatory interactions between a lymphoid and a non lymphoid cell", "Inactivation of cdc42 and rac1", "Inactivation of csf3 g csf signaling", "Incretin synthesis secretion and inactivation", "Infection with mycobacterium tuberculosis", "Infectious disease", "Inflammasomes", "Influenza infection", "Inhibition of dna recombination at telomere", "Inhibition of replication initiation of damaged dna by rb1 e2f1", "Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components", "Initiation of nuclear envelope ne reformation", "Inla mediated entry of listeria monocytogenes into host cells", "Inlb mediated entry of listeria monocytogenes into host cell", "Innate immune system", "Inositol phosphate metabolism", "Insertion of tail anchored proteins into the endoplasmic reticulum membrane", "Insulin processing", "Insulin receptor recycling", "Insulin receptor signalling cascade", "Integration of energy metabolism", "Integration of provirus", "Integrin cell surface interactions", "Integrin signaling", "Interaction between l1 and ankyrins", "Interactions of rev with host cellular proteins", "Interactions of vpr with host cellular proteins", "Interconversion of nucleotide di and triphosphates", "Interferon alpha beta signaling", "Interferon gamma signaling", "Interferon signaling", "Interleukin 1 family signaling", "Interleukin 1 signaling", "Interleukin 10 signaling", "Interleukin 12 family signaling", "Interleukin 12 signaling", "Interleukin 15 signaling", "Interleukin 17 signaling", "Interleukin 2 family signaling", "Interleukin 20 family signaling", "Interleukin 21 signaling", "Interleukin 23 signaling", "Interleukin 27 signaling", "Interleukin 3 interleukin 5 and gm csf signaling", "Interleukin 35 signalling", "Interleukin 37 signaling", "Interleukin 4 and interleukin 13 signaling", "Interleukin 6 family signaling", "Interleukin 6 signaling", "Interleukin 7 signaling", "Interleukin 9 signaling", "Interleukin receptor shc signaling", "Intra golgi and retrograde golgi to er traffic", "Intra golgi traffic", "Intracellular signaling by second messengers", "Intraflagellar transport", "Intrinsic pathway for apoptosis", "Intrinsic pathway of fibrin clot formation", "Ion channel transport", "Ion homeostasis", "Ion transport by p type atpases", "Ionotropic activity of kainate receptors", "Irak1 recruits ikk complex", "Irak4 deficiency tlr2 4", "Ire1alpha activates chaperones", "Irf3 mediated activation of type 1 ifn", "Irf3 mediated induction of type i ifn", "Iron uptake and transport", "Irs mediated signalling", "Jnk c jun kinases phosphorylation and activation mediated by activated human tak1", "Josephin domain dubs", "Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Keratan sulfate keratin metabolism", "Keratinization", "Ketone body metabolism", "Killing mechanisms", "Kinesins", "Ksrp khsrp binds and destabilizes mrna", "L1cam interactions", "Lagging strand synthesis", "Laminin interactions", "Late endosomal microautophagy", "Ldl clearance", "Ldl remodeling", "Leishmania infection", "Lgi adam interactions", "Linoleic acid la metabolism", "Lipophagy", "Listeria monocytogenes entry into host cells", "Long term potentiation", "Loss of function of mecp2 in rett syndrome", "Loss of mecp2 binding ability to the ncor smrt complex", "Lrr flii interacting protein 1 lrrfip1 activates type i ifn production", "Lysine catabolism", "Lysosome vesicle biogenesis", "M phase", "Map2k and mapk activation", "Map3k8 tpl2 dependent mapk1 3 activation", "Mapk family signaling cascades", "Mapk targets nuclear events mediated by map kinases", "Mapk3 erk1 activation", "Mapk6 mapk4 signaling", "Mastl facilitates mitotic progression", "Maturation of protein 3a", "Maturation of sars cov 1 nucleoprotein", "Maturation of sars cov 1 spike protein", "Maturation of sars cov 2 nucleoprotein", "Maturation of sars cov 2 spike protein", "Mecp2 regulates neuronal receptors and channels", "Mecp2 regulates transcription factors", "Mecp2 regulates transcription of neuronal ligands", "Meiosis", "Meiotic recombination", "Meiotic synapsis", "Membrane trafficking", "Met activates pi3k akt signaling", "Met activates ptk2 signaling", "Met activates ptpn11", "Met activates rap1 and rac1", "Met activates ras signaling", "Met interacts with tns proteins", "Met promotes cell motility", "Met receptor recycling", "Metabolic disorders of biological oxidation enzymes", "Metabolism of amino acids and derivatives", "Metabolism of carbohydrates", "Metabolism of cofactors", "Metabolism of fat soluble vitamins", "Metabolism of folate and pterines", "Metabolism of ingested semet sec mesec into h2se", "Metabolism of lipids", "Metabolism of nitric oxide nos3 activation and regulation", "Metabolism of nucleotides", "Metabolism of polyamines", "Metabolism of porphyrins", "Metabolism of rna", "Metabolism of steroid hormones", "Metabolism of steroids", "Metabolism of vitamins and cofactors", "Metabolism of water soluble vitamins and cofactors", "Metalloprotease dubs", "Methionine salvage pathway", "Methylation", "Mhc class ii antigen presentation", "Microrna mirna biogenesis", "Miro gtpase cycle", "Miscellaneous transport and binding events", "Mismatch repair", "Mitochondrial biogenesis", "Mitochondrial calcium ion transport", "Mitochondrial fatty acid beta oxidation", "Mitochondrial fatty acid beta oxidation of saturated fatty acids", "Mitochondrial fatty acid beta oxidation of unsaturated fatty acids", "Mitochondrial iron sulfur cluster biogenesis", "Mitochondrial protein import", "Mitochondrial translation", "Mitochondrial trna aminoacylation", "Mitophagy", "Mitotic g1 phase and g1 s transition", "Mitotic g2 g2 m phases", "Mitotic metaphase and anaphase", "Mitotic prometaphase", "Mitotic prophase", "Mitotic spindle checkpoint", "Mitotic telophase cytokinesis", "Molecules associated with elastic fibres", "Mrna capping", "Mrna decay by 3 to 5 exoribonuclease", "Mrna decay by 5 to 3 exoribonuclease", "Mrna editing", "Mrna splicing", "Mrna splicing minor pathway", "Mtor signalling", "Mtorc1 mediated signalling", "Mucopolysaccharidoses", "Muscle contraction", "Myd88 independent tlr4 cascade", "Myoclonic epilepsy of lafora", "Myogenesis", "N glycan trimming in the er and calnexin calreticulin cycle", "Na cl dependent neurotransmitter transporters", "Nade modulates death signalling", "Ncam signaling for neurite out growth", "Nectin necl trans heterodimerization", "Neddylation", "Nef and signal transduction", "Nef mediated cd4 down regulation", "Nef mediated cd8 down regulation", "Nef mediated downregulation of mhc class i complex cell surface expression", "Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters", "Negative epigenetic regulation of rrna expression", "Negative feedback regulation of mapk pathway", "Negative regulation of fgfr1 signaling", "Negative regulation of fgfr2 signaling", "Negative regulation of fgfr3 signaling", "Negative regulation of fgfr4 signaling", "Negative regulation of flt3", "Negative regulation of mapk pathway", "Negative regulation of met activity", "Negative regulation of nmda receptor mediated neuronal transmission", "Negative regulation of notch4 signaling", "Negative regulation of the pi3k akt network", "Negative regulators of ddx58 ifih1 signaling", "Nephrin family interactions", "Nervous system development", "Netrin 1 signaling", "Neurexins and neuroligins", "Neuronal system", "Neurotransmitter clearance", "Neurotransmitter receptors and postsynaptic signal transmission", "Neurotransmitter release cycle", "Neutrophil degranulation", "Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10", "Nf kb is activated and signals survival", "Ngf stimulated transcription", "Nicotinamide salvaging", "Nicotinate metabolism", "Nod1 2 signaling pathway", "Non integrin membrane ecm interactions", "Noncanonical activation of notch3", "Nonhomologous end joining nhej", "Nonsense mediated decay nmd", "Nostrin mediated enos trafficking", "Notch hlh transcription pathway", "Notch1 intracellular domain regulates transcription", "Notch2 activation and transmission of signal to the nucleus", "Notch3 activation and transmission of signal to the nucleus", "Notch3 intracellular domain regulates transcription", "Notch4 activation and transmission of signal to the nucleus", "Notch4 intracellular domain regulates transcription", "Nr1h2 and nr1h3 mediated signaling", "Nr1h2 nr1h3 regulate gene expression linked to lipogenesis", "Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux", "Nrage signals death through jnk", "Nrcam interactions", "Nrif signals cell death from the nucleus", "Ns1 mediated effects on host pathways", "Ntrk2 activates rac1", "Nuclear envelope breakdown", "Nuclear envelope ne reassembly", "Nuclear events kinase and transcription factor activation", "Nuclear events stimulated by alk signaling in cancer", "Nuclear import of rev protein", "Nuclear pore complex npc disassembly", "Nuclear receptor transcription pathway", "Nuclear signaling by erbb4", "Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways", "Nucleotide biosynthesis", "Nucleotide catabolism", "Nucleotide excision repair", "Nucleotide salvage", "O linked glycosylation", "O linked glycosylation of mucins", "Oas antiviral response", "Oncogene induced senescence", "Oncogenic mapk signaling", "Opioid signalling", "Orc1 removal from chromatin", "Organelle biogenesis and maintenance", "Organic anion transporters", "Other interleukin signaling", "Other semaphorin interactions", "Ovarian tumor domain proteases", "Oxidative stress induced senescence", "P130cas linkage to mapk signaling for integrins", "P38mapk events", "P75 ntr receptor mediated signalling", "P75ntr negatively regulates cell cycle via sc1", "P75ntr recruits signalling complexes", "P75ntr regulates axonogenesis", "P75ntr signals via nf kb", "Parasite infection", "Passive transport by aquaporins", "Pcna dependent long patch base excision repair", "Pcp ce pathway", "Pd 1 signaling", "Pentose phosphate pathway", "Peptide hormone metabolism", "Peptide ligand binding receptors", "Perk regulates gene expression", "Peroxisomal lipid metabolism", "Peroxisomal protein import", "Pexophagy", "Phase 0 rapid depolarisation", "Phase i functionalization of compounds", "Phase ii conjugation of compounds", "Phenylalanine and tyrosine metabolism", "Phenylalanine metabolism", "Phosphate bond hydrolysis by nudt proteins", "Phospholipid metabolism", "Phosphorylation of emi1", "Phosphorylation of the apc c", "Pi 3k cascade fgfr1", "Pi 3k cascade fgfr2", "Pi 3k cascade fgfr3", "Pi 3k cascade fgfr4", "Pi metabolism", "Pi3k akt activation", "Pi3k akt signaling in cancer", "Pi3k events in erbb2 signaling", "Pi5p regulates tp53 acetylation", "Pink1 prkn mediated mitophagy", "Piwi interacting rna pirna biogenesis", "Pka activation in glucagon signalling", "Pka mediated phosphorylation of creb", "Pka mediated phosphorylation of key metabolic factors", "Pkmts methylate histone lysines", "Plasma lipoprotein assembly", "Plasma lipoprotein assembly remodeling and clearance", "Plasma lipoprotein clearance", "Plasma lipoprotein remodeling", "Platelet activation signaling and aggregation", "Platelet adhesion to exposed collagen", "Platelet aggregation plug formation", "Platelet calcium homeostasis", "Platelet homeostasis", "Platelet sensitization by ldl", "Polb dependent long patch base excision repair", "Polo like kinase mediated events", "Polymerase switching", "Polymerase switching on the c strand of the telomere", "Positive epigenetic regulation of rrna expression", "Post chaperonin tubulin folding pathway", "Post translational modification synthesis of gpi anchored proteins", "Post translational protein modification", "Postmitotic nuclear pore complex npc reformation", "Potential therapeutics for sars", "Pou5f1 oct4 sox2 nanog activate genes related to proliferation", "Pp2a mediated dephosphorylation of key metabolic factors", "Prc2 methylates histones and dna", "Pre notch expression and processing", "Pre notch processing in golgi", "Pregnenolone biosynthesis", "Prevention of phagosomal lysosomal fusion", "Processing and activation of sumo", "Processing of capped intron containing pre mrna", "Processing of capped intronless pre mrna", "Processing of dna double strand break ends", "Processing of intronless pre mrnas", "Processing of smdt1", "Processive synthesis on the c strand of the telomere", "Processive synthesis on the lagging strand", "Programmed cell death", "Prolactin receptor signaling", "Prolonged erk activation events", "Propionyl coa catabolism", "Protein folding", "Protein localization", "Protein methylation", "Protein protein interactions at synapses", "Protein repair", "Protein ubiquitination", "Proton coupled monocarboxylate transport", "Pten regulation", "Ptk6 expression", "Ptk6 regulates cell cycle", "Ptk6 regulates proteins involved in rna processing", "Ptk6 regulates rho gtpases ras gtpase and map kinases", "Purine catabolism", "Purine ribonucleoside monophosphate biosynthesis", "Purine salvage", "Purinergic signaling in leishmaniasis infection", "Pyrimidine salvage", "Pyroptosis", "Pyruvate metabolism", "Pyruvate metabolism and citric acid tca cycle", "Ra biosynthesis pathway", "Rab gefs exchange gtp for gdp on rabs", "Rab geranylgeranylation", "Rab regulation of trafficking", "Rac1 gtpase cycle", "Rac2 gtpase cycle", "Rac3 gtpase cycle", "Raf activation", "Raf independent mapk1 3 activation", "Rap1 signalling", "Ras activation upon ca2 influx through nmda receptor", "Ras processing", "Receptor mediated mitophagy", "Recognition and association of dna glycosylase with site containing an affected purine", "Recognition of dna damage by pcna containing replication complex", "Recruitment of mitotic centrosome proteins and complexes", "Recruitment of numa to mitotic centrosomes", "Recycling of eif2 gdp", "Recycling pathway of l1", "Reduction of cytosolic ca levels", "Regulated necrosis", "Regulated proteolysis of p75ntr", "Regulation by c flip", "Regulation of bach1 activity", "Regulation of beta cell development", "Regulation of cholesterol biosynthesis by srebp srebf", "Regulation of commissural axon pathfinding by slit and robo", "Regulation of cytoskeletal remodeling and cell spreading by ipp complex components", "Regulation of expression of slits and robos", "Regulation of fzd by ubiquitination", "Regulation of gene expression in beta cells", "Regulation of gene expression in early pancreatic precursor cells", "Regulation of gene expression in late stage branching morphogenesis pancreatic bud precursor cells", "Regulation of glucokinase by glucokinase regulatory protein", "Regulation of glycolysis by fructose 2 6 bisphosphate metabolism", "Regulation of hmox1 expression and activity", "Regulation of hsf1 mediated heat shock response", "Regulation of ifna signaling", "Regulation of ifng signaling", "Regulation of innate immune responses to cytosolic dna", "Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps", "Regulation of insulin secretion", "Regulation of kit signaling", "Regulation of lipid metabolism by pparalpha", "Regulation of localization of foxo transcription factors", "Regulation of mecp2 expression and activity", "Regulation of mrna stability by proteins that bind au rich elements", "Regulation of plk1 activity at g2 m transition", "Regulation of pten gene transcription", "Regulation of pten localization", "Regulation of pten mrna translation", "Regulation of pten stability and activity", "Regulation of pyruvate dehydrogenase pdh complex", "Regulation of ras by gaps", "Regulation of runx1 expression and activity", "Regulation of runx2 expression and activity", "Regulation of runx3 expression and activity", "Regulation of signaling by cbl", "Regulation of tlr by endogenous ligand", "Regulation of tnfr1 signaling", "Regulation of tp53 activity", "Regulation of tp53 activity through acetylation", "Regulation of tp53 activity through association with co factors", "Regulation of tp53 activity through methylation", "Regulation of tp53 activity through phosphorylation", "Regulation of tp53 expression and degradation", "Release of apoptotic factors from the mitochondria", "Release of hh np from the secreting cell", "Repression of wnt target genes", "Reproduction", "Resolution of abasic sites ap sites", "Resolution of ap sites via the multiple nucleotide patch replacement pathway", "Resolution of d loop structures", "Resolution of d loop structures through synthesis dependent strand annealing sdsa", "Resolution of sister chromatid cohesion", "Respiratory electron transport", "Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins", "Response of eif2ak1 hri to heme deficiency", "Response of eif2ak4 gcn2 to amino acid deficiency", "Response of mtb to phagocytosis", "Response to elevated platelet cytosolic ca2", "Ret signaling", "Retrograde neurotrophin signalling", "Retrograde transport at the trans golgi network", "Rho gtpase cycle", "Rho gtpase effectors", "Rho gtpases activate cit", "Rho gtpases activate formins", "Rho gtpases activate iqgaps", "Rho gtpases activate ktn1", "Rho gtpases activate nadph oxidases", "Rho gtpases activate paks", "Rho gtpases activate pkns", "Rho gtpases activate rhotekin and rhophilins", "Rho gtpases activate rocks", "Rho gtpases activate wasps and waves", "Rhoa gtpase cycle", "Rhob gtpase cycle", "Rhobtb gtpase cycle", "Rhobtb1 gtpase cycle", "Rhobtb2 gtpase cycle", "Rhobtb3 atpase cycle", "Rhoc gtpase cycle", "Rhod gtpase cycle", "Rhof gtpase cycle", "Rhog gtpase cycle", "Rhoh gtpase cycle", "Rhoj gtpase cycle", "Rhoq gtpase cycle", "Rhot1 gtpase cycle", "Rhou gtpase cycle", "Rhov gtpase cycle", "Rip mediated nfkb activation via zbp1", "Ripk1 mediated regulated necrosis", "Rmts methylate histone arginines", "Rna polymerase i promoter escape", "Rna polymerase i transcription", "Rna polymerase i transcription initiation", "Rna polymerase i transcription termination", "Rna polymerase ii transcribes snrna genes", "Rna polymerase ii transcription", "Rna polymerase ii transcription termination", "Rna polymerase iii chain elongation", "Rna polymerase iii transcription", "Rna polymerase iii transcription initiation from type 1 promoter", "Rna polymerase iii transcription initiation from type 3 promoter", "Rna polymerase iii transcription termination", "Rnd1 gtpase cycle", "Rnd2 gtpase cycle", "Rnd3 gtpase cycle", "Robo receptors bind akap5", "Role of abl in robo slit signaling", "Role of lat2 ntal lab on calcium mobilization", "Role of phospholipids in phagocytosis", "Role of second messengers in netrin 1 signaling", "Rora activates gene expression", "Ros and rns production in phagocytes", "Rrna modification in the nucleus and cytosol", "Rrna processing", "Rrna processing in the mitochondrion", "Rsk activation", "Runx1 interacts with co factors whose precise effect on runx1 targets is not known", "Runx1 regulates expression of components of tight junctions", "Runx1 regulates genes involved in megakaryocyte differentiation and platelet function", "Runx1 regulates transcription of genes involved in differentiation of hscs", "Runx2 regulates bone development", "Runx2 regulates genes involved in cell migration", "Runx3 regulates cdkn1a transcription", "Runx3 regulates notch signaling", "Runx3 regulates p14 arf", "Runx3 regulates wnt signaling", "S phase", "Sars cov 1 infection", "Sars cov 2 infection", "Sars cov infections", "Scavenging by class a receptors", "Scavenging by class b receptors", "Scavenging by class f receptors", "Scf skp2 mediated degradation of p27 p21", "Sealing of the nuclear envelope ne by escrt iii", "Selective autophagy", "Selenoamino acid metabolism", "Sema3a pak dependent axon repulsion", "Sema3a plexin repulsion signaling by inhibiting integrin adhesion", "Sema4d in semaphorin signaling", "Sema4d induced cell migration and growth cone collapse", "Sema4d mediated inhibition of cell attachment and migration", "Semaphorin interactions", "Senescence associated secretory phenotype sasp", "Sensing of dna double strand breaks", "Sensory perception", "Sensory processing of sound", "Sensory processing of sound by outer hair cells of the cochlea", "Separation of sister chromatids", "Serine biosynthesis", "Shc mediated cascade fgfr1", "Shc mediated cascade fgfr3", "Shc mediated cascade fgfr4", "Shc related events triggered by igf1r", "Shc1 events in egfr signaling", "Shc1 events in erbb2 signaling", "Shc1 events in erbb4 signaling", "Sialic acid metabolism", "Signal amplification", "Signal attenuation", "Signal regulatory protein family interactions", "Signal transduction by l1", "Signaling by alk", "Signaling by alk in cancer", "Signaling by bmp", "Signaling by braf and raf1 fusions", "Signaling by csf3 g csf", "Signaling by ctnnb1 phospho site mutants", "Signaling by cytosolic fgfr1 fusion mutants", "Signaling by egfr", "Signaling by egfr in cancer", "Signaling by erbb2", "Signaling by erbb2 ecd mutants", "Signaling by erbb2 in cancer", "Signaling by erbb4", "Signaling by erythropoietin", "Signaling by fgfr", "Signaling by fgfr in disease", "Signaling by fgfr1", "Signaling by fgfr1 in disease", "Signaling by fgfr2", "Signaling by fgfr2 iiia tm", "Signaling by fgfr2 in disease", "Signaling by fgfr3", "Signaling by fgfr3 fusions in cancer", "Signaling by fgfr4", "Signaling by fgfr4 in disease", "Signaling by flt3 fusion proteins", "Signaling by flt3 itd and tkd mutants", "Signaling by gpcr", "Signaling by hedgehog", "Signaling by hippo", "Signaling by insulin receptor", "Signaling by interleukins", "Signaling by kit in disease", "Signaling by leptin", "Signaling by mapk mutants", "Signaling by met", "Signaling by moderate kinase activity braf mutants", "Signaling by mras complex mutants", "Signaling by notch", "Signaling by notch1", "Signaling by notch1 hd domain mutants in cancer", "Signaling by notch1 pest domain mutants in cancer", "Signaling by notch1 t 7 9 notch1 m1580 k2555 translocation mutant", "Signaling by notch2", "Signaling by notch3", "Signaling by notch4", "Signaling by ntrk2 trkb", "Signaling by ntrk3 trkc", "Signaling by ntrks", "Signaling by nuclear receptors", "Signaling by pdgf", "Signaling by pdgfr in disease", "Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants", "Signaling by ptk6", "Signaling by receptor tyrosine kinases", "Signaling by retinoic acid", "Signaling by rho gtpases miro gtpases and rhobtb3", "Signaling by robo receptors", "Signaling by scf kit", "Signaling by tgf beta receptor complex", "Signaling by tgfb family members", "Signaling by the b cell receptor bcr", "Signaling by type 1 insulin like growth factor 1 receptor igf1r", "Signaling by vegf", "Signaling by wnt", "Signaling by wnt in cancer", "Signalling to erks", "Signalling to ras", "Sirt1 negatively regulates rrna expression", "Slbp dependent processing of replication dependent histone pre mrnas", "Slc mediated transmembrane transport", "Slc transporter disorders", "Smac xiap regulated apoptotic response", "Smad2 smad3 smad4 heterotrimer regulates transcription", "Small interfering rna sirna biogenesis", "Smooth muscle contraction", "Snrnp assembly", "Sodium calcium exchangers", "Sos mediated signalling", "Sphingolipid de novo biosynthesis", "Sphingolipid metabolism", "Spry regulation of fgf signaling", "Srp dependent cotranslational protein targeting to membrane", "Stabilization of p53", "Stat3 nuclear events downstream of alk signaling", "Stat5 activation", "Stat5 activation downstream of flt3 itd mutants", "Stimuli sensing channels", "Sting mediated induction of host immune responses", "Striated muscle contraction", "Sulfide oxidation to sulfate", "Sulfur amino acid metabolism", "Sumo is conjugated to e1 uba2 sae1", "Sumo is transferred from e1 to e2 ube2i ubc9", "Sumoylation", "Sumoylation of chromatin organization proteins", "Sumoylation of dna damage response and repair proteins", "Sumoylation of dna methylation proteins", "Sumoylation of dna replication proteins", "Sumoylation of rna binding proteins", "Sumoylation of sumoylation proteins", "Sumoylation of transcription cofactors", "Sumoylation of transcription factors", "Sumoylation of ubiquitinylation proteins", "Suppression of apoptosis", "Suppression of phagosomal maturation", "Surfactant metabolism", "Switching of origins to a post replicative state", "Synaptic adhesion like molecules", "Syndecan interactions", "Synthesis of 5 eicosatetraenoic acids", "Synthesis of active ubiquitin roles of e1 and e2 enzymes", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol", "Synthesis of diphthamide eef2", "Synthesis of dna", "Synthesis of gdp mannose", "Synthesis of ip2 ip and ins in the cytosol", "Synthesis of ketone bodies", "Synthesis of leukotrienes lt and eoxins ex", "Synthesis of lipoxins lx", "Synthesis of pa", "Synthesis of pc", "Synthesis of pe", "Synthesis of pg", "Synthesis of pi", "Synthesis of pips at the er membrane", "Synthesis of pips at the golgi membrane", "Synthesis of pips at the plasma membrane", "Synthesis of prostaglandins pg and thromboxanes tx", "Synthesis of pyrophosphates in the cytosol", "Synthesis of substrates in n glycan biosythesis", "Synthesis of udp n acetyl glucosamine", "Synthesis of very long chain fatty acyl coas", "Synthesis secretion and deacylation of ghrelin", "Synthesis secretion and inactivation of glucagon like peptide 1 glp 1", "Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip", "Tak1 activates nfkb by phosphorylation and activation of ikks complex", "Tbc rabgaps", "Tcf dependent signaling in response to wnt", "Tcr signaling", "Telomere c strand lagging strand synthesis", "Telomere c strand synthesis initiation", "Telomere extension by telomerase", "Telomere maintenance", "Termination of translesion dna synthesis", "Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation", "Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation", "Tgf beta receptor signaling activates smads", "Tgf beta receptor signaling in emt epithelial to mesenchymal transition", "The activation of arylsulfatases", "The canonical retinoid cycle in rods twilight vision", "The citric acid tca cycle and respiratory electron transport", "The nlrp3 inflammasome", "The phototransduction cascade", "The role of gtse1 in g2 m progression after g2 checkpoint", "The role of nef in hiv 1 replication and disease pathogenesis", "Thrombin signalling through proteinase activated receptors pars", "Thromboxane signalling through tp receptor", "Ticam1 rip1 mediated ikk complex recruitment", "Tie2 signaling", "Tight junction interactions", "Tlr3 mediated ticam1 dependent programmed cell death", "Tnf signaling", "Tnfr1 induced nfkappab signaling pathway", "Tnfr1 induced proapoptotic signaling", "Tnfr1 mediated ceramide production", "Tnfr2 non canonical nf kb pathway", "Toll like receptor 9 tlr9 cascade", "Toll like receptor cascades", "Toll like receptor tlr1 tlr2 cascade", "Tp53 regulates metabolic genes", "Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "Tp53 regulates transcription of caspase activators and caspases", "Tp53 regulates transcription of cell cycle genes", "Tp53 regulates transcription of cell death genes", "Tp53 regulates transcription of death receptors and ligands", "Tp53 regulates transcription of dna repair genes", "Tp53 regulates transcription of genes involved in cytochrome c release", "Tp53 regulates transcription of genes involved in g1 cell cycle arrest", "Tp53 regulates transcription of genes involved in g2 cell cycle arrest", "Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain", "Traf3 dependent irf activation pathway", "Traf6 mediated irf7 activation", "Traf6 mediated irf7 activation in tlr7 8 or 9 signaling", "Traf6 mediated nf kb activation", "Trafficking and processing of endosomal tlr", "Trafficking of ampa receptors", "Trafficking of glur2 containing ampa receptors", "Trafficking of myristoylated proteins to the cilium", "Trans golgi network vesicle budding", "Transcription coupled nucleotide excision repair tc ner", "Transcription of e2f targets under negative control by dream complex", "Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1", "Transcription of the hiv genome", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activity of smad2 smad3 smad4 heterotrimer", "Transcriptional regulation by e2f6", "Transcriptional regulation by mecp2", "Transcriptional regulation by runx1", "Transcriptional regulation by runx2", "Transcriptional regulation by runx3", "Transcriptional regulation by small rnas", "Transcriptional regulation by the ap 2 tfap2 family of transcription factors", "Transcriptional regulation by tp53", "Transcriptional regulation by ventx", "Transcriptional regulation of granulopoiesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation of white adipocyte differentiation", "Transferrin endocytosis and recycling", "Translation", "Translation of replicase and assembly of the replication transcription complex", "Translation of sars cov 1 structural proteins", "Translation of sars cov 2 structural proteins", "Translesion synthesis by polh", "Translesion synthesis by polk", "Translesion synthesis by y family dna polymerases bypasses lesions on dna template", "Translocation of slc2a4 glut4 to the plasma membrane", "Transmission across chemical synapses", "Transport and synthesis of paps", "Transport of bile salts and organic acids metal ions and amine compounds", "Transport of connexons to the plasma membrane", "Transport of fatty acids", "Transport of inorganic cations anions and amino acids oligopeptides", "Transport of mature mrnas derived from intronless transcripts", "Transport of mature transcript to cytoplasm", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "Transport of nucleotide sugars", "Transport of small molecules", "Transport of the slbp dependant mature mrna", "Transport of vitamins nucleosides and related molecules", "Transport to the golgi and subsequent modification", "Trif mediated programmed cell death", "Triglyceride catabolism", "Triglyceride metabolism", "Tristetraprolin ttp zfp36 binds and destabilizes mrna", "Trna aminoacylation", "Trna modification in the mitochondrion", "Trna modification in the nucleus and cytosol", "Trna processing", "Trna processing in the mitochondrion", "Trna processing in the nucleus", "Trp channels", "Tryptophan catabolism", "Type i hemidesmosome assembly", "Tyrosine catabolism", "Tysnd1 cleaves peroxisomal proteins", "Ub specific processing proteases", "Uch proteinases", "Unblocking of nmda receptors glutamate binding and activation", "Unfolded protein response upr", "Unwinding of dna", "Uptake and actions of bacterial toxins", "Uptake and function of anthrax toxins", "Uptake and function of diphtheria toxin", "Urea cycle", "Vasopressin regulates renal water homeostasis via aquaporins", "Vegfr2 mediated cell proliferation", "Vegfr2 mediated vascular permeability", "Vesicle mediated transport", "Viral messenger rna synthesis", "Visual phototransduction", "Vitamin b1 thiamin metabolism", "Vitamin b2 riboflavin metabolism", "Vitamin b5 pantothenate metabolism", "Vitamin c ascorbate metabolism", "Vitamin d calciferol metabolism", "Vldl assembly", "Vldlr internalisation and degradation", "Vxpx cargo targeting to cilium", "Wax and plasmalogen biosynthesis", "Wnt ligand biogenesis and trafficking", "Wnt mediated activation of dvl", "Wnt5a dependent internalization of fzd2 fzd5 and ror2", "Wnt5a dependent internalization of fzd4", "Zbp1 dai mediated induction of type i ifns"], "available_proteins": ["AAAS", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADAM17", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANLN", "ANXA1", "ANXA2", "ANXA6", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3M1", "AP3S1", "APEH", "APEX1", "APLP2", "APOO", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP5", "ARMCX3", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD3B", "ATG4B", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "B4GAT1", "BABAM1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BRCA1", "BRD2", "BSG", "BUB1B", "BUB3", "BUD23", "BYSL", "C19orf70", "C1QBP", "C1orf35", "CAD", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD3EAP", "CDC23", "CDC27", "CDC34", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CENPI", "CERS2", "CFL1", "CHAF1B", "CHAMP1", "CHCHD3", "CHD4", "CHERP", "CHID1", "CHKA", "CHMP3", "CHMP7", "CHORDC1", "CHST14", "CHTF18", "CIAPIN1", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLINT1", "CLNS1A", "CLTC", "CMAS", "CMPK1", "CNDP2", "CNN2", "CNOT1", "CNOT10", "CNOT3", "CNOT6", "CNOT7", "CNOT9", "COG7", "COLGALT1", "COMMD2", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CRKL", "CRNKL1", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CWC15", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DCAF13", "DCAF7", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDB1", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX52", "DDX56", "DDX6", "DEK", "DERL1", "DFFA", "DGCR8", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHX15", "DHX16", "DHX36", "DHX37", "DHX38", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DPH2", "DPM1", "DPYSL2", "DSG2", "DSP", "DST", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI2", "ECSIT", "EDC3", "EDC4", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFTUD2", "EHD1", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELOA", "ELOB", "ELP1", "ELP2", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "ENSA", "ENY2", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERCC2", "ERCC3", "ERCC6L", "ERLIN2", "ERO1A", "ERP44", "ESD", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "F11R", "FADS2", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120B", "FAM49B", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FDFT1", "FDPS", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP14", "FKBP4", "FKBP5", "FKBP8", "FLAD1", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FN3KRP", "FNTB", "FOXK1", "FSCN1", "FTO", "FTSJ3", "FUCA2", "FUS", "FXR1", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GINS1", "GINS4", "GLA", "GLB1", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLUD1", "GM2A", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNL3", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLGB1", "GOLIM4", "GORASP2", "GOT1", "GOT2", "GPAA1", "GPD2", "GPI", "GPS1", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP3", "GUSB", "GYS1", "H1F0", "H2AFX", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAUS5", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HEBP1", "HECTD1", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIF1AN", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HPRT1", "HSD17B10", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IGF2BP1", "IGF2BP3", "IGF2R", "ILF2", "ILK", "IMMT", "IMP3", "IMPDH2", "INCENP", "INTS11", "INTS14", "INTS3", "IPO5", "IPO8", "IPO9", "IQGAP1", "IRS4", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0391", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KLC2", "KLC4", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMP1", "LAMTOR1", "LAMTOR2", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3BP", "LGMN", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LNPEP", "LPCAT1", "LRPPRC", "LRRC1", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LTV1", "LYPLA1", "MAGED2", "MAGT1", "MAP2K1", "MAPRE1", "MARC1", "MARCKS", "MARS", "MAT2A", "MAU2", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDC1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED16", "METAP2", "MFN1", "MFN2", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINPP1", "MIPEP", "MLEC", "MMAB", "MMGT1", "MMS19", "MOGS", "MORF4L1", "MOV10", "MPHOSPH10", "MPI", "MPP2", "MPRIP", "MPST", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTR", "MTX1", "MTX2", "MYBBP1A", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1C", "MYO6", "NAA35", "NADK2", "NAGK", "NAGLU", "NAMPT", "NANS", "NAPA", "NAPG", "NARS", "NAT10", "NAXE", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCSTN", "NDC1", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFAF7", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4L", "NEFL", "NEK9", "NELFCD", "NEU1", "NHLRC2", "NHP2", "NIP7", "NIPBL", "NISCH", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC4L", "NOL11", "NOL6", "NOL9", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NPTN", "NRBP1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NT5C2", "NT5C3B", "NUB1", "NUBP2", "NUCB1", "NUDC", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NXF1", "OAT", "OCLN", "OGDH", "OGT", "OLA1", "OPA1", "OSBP", "OSBPL11", "OSBPL6", "OSBPL9", "OTUB1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK2", "PAK4", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCM1", "PCMT1", "PCNA", "PDCD11", "PDCD4", "PDCD6", "PDCD6IP", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA6", "PDK3", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PEBP1", "PECR", "PELP1", "PES1", "PEX14", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIGS", "PIGT", "PIR", "PISD", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PMPCA", "PMPCB", "PNO1", "PNP", "PNPLA6", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPID", "PPIH", "PPIL1", "PPIL4", "PPME1", "PPP1CA", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PPP6R3", "PPT1", "PQBP1", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF6", "PRPF8", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", 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pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Alzheimers disease 18 69 3.5568477911433147 0.0003753314746528 18.929611650485437 83.0752427184466 0.8523996335219438 0.5089902911900335 9.09856474570077 6.061710858604258 1.0800674607776464 0.3865214102951685 1.0 0.0023950081642668 0.0001161422889627 7.813243135463463e-05 0.0011782082468798 +Alzheimers disease and mirna effects 18 70 3.5037356265508284 0.0004587805783535 19.78640776699029 84.62864077669903 0.8675405351918691 0.5019659822826982 9.06411947478317 6.212690980603589 1.0744065053186531 0.3869842050583563 1.0 0.0025583627075256 0.0001303795229508 9.280137958590482e-05 0.0005771442988238 +Sphingolipid metabolism in senescence 4 9 2.820591126421951 0.00479352567105 4.349514563106796 11.679611650485436 1.1898351622318797 0.2087194733713789 1.8732078185138223 1.4259290429724831 1.4063103725171229 0.2533781048666968 1.0 0.000172657384578 6.426860752013887e-05 0.0001850299811141 0.0041129787740785 +Sphingolipid pathway 3 7 2.4632416464851024 0.0137687084219646 4.274271844660194 9.393203883495143 1.2258474538683668 0.1888473674707098 2.02173101931241 1.3620203536909472 1.3696572221543342 0.2416569853225122 1.0 0.0049155620827658 0.0011959433226113 0.0017174581383874 0.0193421266882966 +Degradation pathway of sphingolipids including diseases 4 7 2.4335672717893027 0.01495085693811 3.645631067961165 6.432038834951456 0.0687547082162972 0.1728701573933007 1.3368036576958324 0.5554170290527195 1.9109030412897592 0.2451148181788838 1.0 0.0424464003246627 0.0032139762811053 9.14133433735114e-07 2.6949933129058047e-05 +Electron transport chain oxphos system in mitochondria 10 40 2.2630700170349294 0.0236313734837154 17.57766990291262 50.45631067961165 1.00621396752225 0.3125021459260491 7.648293572467493 4.538458527560961 1.9412236823915887 0.3642771965747766 1.0 0.3561784256622231 0.0584891686146332 1.1116401880288308e-05 5.846117424100816e-06 +Sphingolipid metabolism integrated pathway 2 5 2.2470160837625888 0.0246389992327105 4.058252427184466 8.101941747572816 1.3056837288293504 0.1731905617886817 2.1182299017960826 1.603786816240382 1.4154175704443392 0.233855234687812 1.0 0.0036723611473879 0.0007685743700876 0.0101015401572799 0.0603054088989602 +Sphingolipid metabolism overview 2 5 2.2470160837625888 0.0246389992327105 4.0 7.951456310679611 1.305604070038762 0.1692072490812911 2.0060587839493125 1.5113078035984122 1.4254327231792938 0.2283290755268721 1.0 0.0029386578360865 0.0005470061355849 0.0073447144383531 0.0453992028175155 +Familial partial lipodystrophy fpld 2 7 2.127211775909588 0.0334024911342394 2.7354368932038833 7.351941747572815 1.0487704575374006 0.2220749325398317 1.64741826657551 0.7567951823729889 1.2080189526980365 0.2461617416466816 1.0 1.0 0.0173819675279631 0.0901924811619011 0.0771884402518302 +Pathogenic escherichia coli infection 3 20 2.122973528363381 0.0337560701685999 8.04368932038835 23.04126213592233 -0.1828642907559088 0.5748742925026463 4.5754764175075255 2.330828920267767 0.9569379411043492 0.3191018272971252 1.0 0.1952735388158895 0.0009182879541791 0.0227330174276438 0.0633296250195141 +Cholesterol metabolism with bloch and kandutschrussell pathways 4 18 2.1036146031287672 0.0354120790679368 7.092233009708738 23.070388349514563 1.3045876527781233 0.2885598195159411 3.1892169450204397 2.132138915277104 1.1515799969949023 0.3088028425519339 1.0 0.1635258499471353 0.0004319372914338 0.001820540651884 0.0016618889829961 +Cholesterol biosynthesis with skeletal dysplasias 4 5 2.044100246461125 0.0409436448199667 2.703883495145631 6.024271844660194 1.6250539245333766 0.1427602110791373 1.3052115351448448 0.7101163612316155 0.9675759117714408 0.205892393525391 1.0 0.0331691185540615 3.0215676113329712e-05 1.093284607508717e-05 4.869188728296504e-06 diff --git a/msigdb_wp/metrics.json b/msigdb_wp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..da8610a4af7fd16643d5c3f8623fb7889ca8c61e --- /dev/null +++ b/msigdb_wp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2454, + "annotations_size": 574, + "title": "Average number of proteins per term", + "value": 8.27177700348432 +} \ No newline at end of file diff --git a/msigdb_wp/paths.json b/msigdb_wp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..0cd77d12ebf6d7e49193496998a56985c1758979 --- /dev/null +++ b/msigdb_wp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_wp/fragment/C340/C340_val_log2fc"} \ No newline at end of file diff --git a/msigdb_wp/result.tsv b/msigdb_wp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..f74b8ee2226c5551bda27c6800e85b2c6603ec1f --- /dev/null +++ b/msigdb_wp/result.tsv @@ -0,0 +1,120 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Alzheimers disease 0.5911362217502134 3.5568477911433147 0.0003753314746528 0.1938461770295437 0.1260692247147833 69 P45880,O95197,P28070,Q9BUF5,P28072,P05067,P49721,Q9BVA1,P20618,Q9NSK0,P60900,P07437,Q08752,P31751,P21796,Q99436,P28074,P68371 18 +Alzheimers disease and mirna effects 0.5838247572287294 3.5037356265508284 0.0004587805783535 0.2315659053511057 0.1260692247147833 70 P45880,O95197,P28070,Q9BUF5,P28072,P05067,P49721,Q9BVA1,P20618,Q9NSK0,P60900,P07437,Q08752,P31751,P21796,Q99436,P28074,P68371 18 +Sphingolipid metabolism in senescence 0.9052258646671788 2.820591126421951 0.00479352567105 0.9365878337732548 0.1260692247147833 9 P16278,Q96G23,Q13510,Q06136 4 +Sphingolipid pathway 0.8959653765344436 2.4632416464851024 0.0137687084219646 0.9996502010398692 0.239492079824476 7 Q13510,Q96G23,Q06136 3 +Degradation pathway of sphingolipids including diseases 0.888750582343406 2.4335672717893027 0.01495085693811 0.9998242751493068 0.2524056436022108 7 P17900,P06280,P16278,O43681 4 +Electron transport chain oxphos system in mitochondria 0.5271881662389558 2.2630700170349294 0.0236313734837154 0.9999989077292504 0.3140263836782578 40 O75306,Q9UDW1,P31930,O75964,P00403,P14406,P20674,O43676,O14949,Q9UII2 10 +Sphingolipid metabolism integrated pathway 0.9218107314305344 2.2470160837625888 0.0246389992327105 0.9999993961460584 0.3140263836782578 5 Q96G23,Q06136 2 +Sphingolipid metabolism overview 0.9218107314305344 2.2470160837625888 0.0246389992327105 0.9999993961460584 0.3140263836782578 5 Q96G23,Q06136 2 +Familial partial lipodystrophy fpld 0.8157360011387031 2.1272117759095877 0.0334024911342394 0.9999999966036264 0.3399295487153748 7 O60725,O75844 2 +Pathogenic escherichia coli infection 0.6014110631618745 2.122973528363381 0.0337560701685999 0.9999999972469702 0.3399295487153748 20 Q9BUF5,P07437,P68371 3 +Cholesterol metabolism with bloch and kandutschrussell pathways 0.611024233657492 2.1036146031287672 0.0354120790679368 0.9999999989715004 0.3445175149999281 18 Q9UBM7,P48449,Q16850,Q14739 4 +Cholesterol biosynthesis with skeletal dysplasias 0.8709677419354793 2.044100246461125 0.0409436448199667 0.9999999999621096 0.3613653301470194 5 Q9UBM7,Q15392,Q16850,Q14739 4 +Drug induction of bile acid pathway 0.9384176182707996 2.0194604273797863 0.043439386376558 0.9999999999915088 0.3613653301470194 2 P08183 1 +Ketogenesis and ketolysis 0.8771787641644553 1.9419797514968484 0.0521395516163929 0.9999999999999551 0.3983664788188207 4 O43772 1 +Nonalcoholic fatty liver disease 0.4905366287507638 1.8967930030569164 0.0578552631605306 0.9999999999999986 0.4099866796807977 37 O75306,Q9UDW1,P31930,P22695,P00403,P14406,P20674,O43676,O14949 9 +Mitochondrial long chain fatty acid betaoxidation 0.6426872434277724 1.876981079093448 0.0605206871582284 0.9999999999999998 0.4236448101075991 12 Q16836,O43772,P40939,P23786 4 +Mitochondrial complex iii assembly 0.8029585077395545 1.859185337335355 0.0630008724322155 1.0 0.4356927804348399 6 O14949,Q6DKK2,Q9UDW1,P31930 4 +Relationship between inflammation cox2 and egfr 0.889070146818919 1.8114799602376508 0.0700665883753568 1.0 0.4676537410169166 2 Q9H7Z7 1 +Cholesterol biosynthesis pathway 0.6782157949823868 1.792093233254224 0.0731180326513523 1.0 0.4697890261124846 9 P48449,Q16850 2 +Congenital generalized lipodystrophy cgl 0.8723491027732468 1.7404230253244222 0.0817847653680072 1.0 0.4697890261124846 2 P31751 1 +Fatty acid betaoxidation 0.5518704494524346 1.7079010237480838 0.0876547092108901 1.0 0.4748359425034993 17 Q16836,O43772,P40939,P23786 4 +Vitamin d metabolism 0.930589061125079 1.6904176155641837 0.090948087298941 1.0 0.4748359425034993 3 Q9UBM7 1 +Parkinubiquitin proteasomal system pathway 0.4834496400184727 1.6784151503446825 0.0932660820103332 1.0 0.4748359425034993 31 Q9BUF5,P07437,P68371 3 +Oxidation by cytochrome p450 0.7785578713719425 1.664763859426719 0.0959598768822402 1.0 0.4748359425034993 5 Q16850 1 +Glycosaminoglycan degradation 0.7422625943155745 1.60435619161721 0.1086355616143306 1.0 0.5057044943772101 6 P15586,P54802,P16278,P08236 4 +Tryptophan metabolism 0.5634343713849901 1.5993505526446588 0.109742732755419 1.0 0.5057044943772101 14 O94788,Q16836,P40939 3 +Proteasome degradation 0.4449581558594565 1.5982144912286764 0.1099952497662304 1.0 0.5057044943772101 41 P28070,O75832,P28072,P49721,P20618,P60900,Q99436,P28074 8 +Mitochondrial complex iv assembly 0.6233188557944239 1.586156826924069 0.112703738616263 1.0 0.5057044943772101 10 P00403,P14406 2 +Pregnane x receptor pathway 0.7586988279798726 1.581690569199176 0.1137202266893699 1.0 0.5057044943772101 5 P08183 1 +Camkk2 pathway 0.6909439747937904 1.5788703158148365 0.1143658059663477 1.0 0.5057044943772101 7 P09601 1 +Progeriaassociated lipodystrophy 0.6334070248244654 1.5743204035226783 0.1154133950582134 1.0 0.5057044943772101 9 O60725 1 +S1p receptor signal transduction 0.7783673469387731 1.5404227330322064 0.123457343638897 1.0 0.5132937498579279 4 P04899,P31751,Q13510 3 +Kennedy pathway from sphingolipids 0.7685714285714262 1.500045091547038 0.1336027226352087 1.0 0.5349608713347117 4 P48651,P35790,Q9UG56 3 +Riboflavin and coq disorders 0.8796409628723014 1.493591628200186 0.1352823889279302 1.0 0.5349608713347117 3 Q16134,P13804 2 +Eicosanoid synthesis 0.813621533442078 1.4892359629545122 0.1364252438088704 1.0 0.5349608713347117 2 Q9H7Z7 1 +Folate metabolism 0.5450050953104557 1.4443397927918014 0.1486434175401643 1.0 0.5480203198830538 13 P00374,P41440,Q8WTV0 3 +Ferroptosis 0.5052568698210395 1.442694080447433 0.1491066675109291 1.0 0.5480203198830538 18 P45880,P09601 2 +Inclusion body myositis 0.8013866231647534 1.4367244072457304 0.1507963169462285 1.0 0.5480203198830538 2 P05067 1 +Urea cycle and related diseases 0.7911908646003141 1.392958638689983 0.1636322985610079 1.0 0.5480203198830538 2 Q9Y619 1 +Nad biosynthetic pathways 0.7411527618900497 1.3866778504514166 0.1655400175664911 1.0 0.5480203198830538 4 P43490 1 +Proteoglycan biosynthesis 0.7883360522022822 1.3807057454472065 0.1673694540244357 1.0 0.5480203198830538 2 Q8TB61 1 +Photodynamic therapyinduced nfe2l2 nrf2 survival signaling 0.738254169202818 1.3746697425924854 0.1692338558495489 1.0 0.5480203198830538 4 P07099,P09601 2 +Cytosine methylation 0.7094595292267516 1.373970360537163 0.1694508842082926 1.0 0.5480203198830538 5 P48735 1 +Intracellular trafficking proteins involved in cmt neuropathy 0.6875926561660183 1.3706456409803247 0.1704854478715325 1.0 0.5480203198830538 6 Q9NR77,P04792 2 +Nanomaterial induced apoptosis 0.7365324523820245 1.3675355514350236 0.1714575017825321 1.0 0.5480203198830538 4 Q9NR28,O95831 2 +Mitochondrial complex i assembly model oxphos system 0.4876382570089744 1.3569051315402103 0.1748113561412516 1.0 0.5480203198830538 19 Q8IUX1,O75306,Q8N183,O43676,Q9P032,Q9Y375 6 +Purinergic signaling 0.7777324632952722 1.335210595282506 0.1818074300784689 1.0 0.5495864596482561 2 P04899 1 +Metapathway biotransformation phase i and ii 0.487473752866627 1.327366676880107 0.1843874172244928 1.0 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P61962,Q92600,O95721,Q99627,P08670,P06280,P48556,Q13409,P60660,O60645,P16278,A0AVF1,Q15024,Q9H9A5,Q16795,O43464,Q9HDC9,Q92905,Q9Y266,O15173,Q9BT78,P10619,Q9BW83,P61106,Q15555,Q96PK6 26 +Orexin receptor pathway 0.3877742960095551 0.4010331977658964 0.6883956823716262 1.0 0.9498536578877728 10 P20290,Q00059 2 +Dna replication 0.3337660850036568 0.3828718979548409 0.7018147487794115 1.0 0.9560023922082318 22 Q9Y619,P41440,P35250 3 +Burn wound healing 0.411776510909106 0.3441571844677402 0.7307280795229489 1.0 0.9602270221648792 7 P08670,P07737 2 +Interactions between loxl4 and oxidative stress pathway 0.521615008156617 0.3418958825739356 0.7324292483576724 1.0 0.9602270221648792 2 Q16543 1 +Proximal tubule transport 0.3758941583001867 0.3246286503795741 0.7454621407694519 1.0 0.9633472148583844 9 P08183 1 +16p112 distal deletion syndrome 0.4434463046141277 0.3137175511963102 0.7537355693442234 1.0 0.9633472148583844 5 P20339,P62993,Q8WWM7,Q99873 4 +Ectoderm differentiation 0.3383770323322712 0.3067307226700582 0.7590483429701935 1.0 0.9633472148583844 15 P16278 1 +Nsp1 from sarscov2 inhibits translation initiation in the host cell 0.3428138665705195 0.3002818786141646 0.7639621545779369 1.0 0.9633472148583844 13 P60228,O15372,P56537,P55010 4 +Initiation of transcription and translation elongation at the hiv1 ltr 0.4580336409086784 0.2993893265793533 0.7646430050678406 1.0 0.9633472148583844 4 O00267 1 +Ketone bodies synthesis and degradation 0.4955138662316529 0.2697765539809285 0.7873321614687809 1.0 0.9633472148583844 2 P35914 1 +Neural crest cell migration in cancer 0.3901151950486611 0.2659813718828484 0.7902535555115675 1.0 0.9633472148583844 7 Q99523 1 +Hippo signaling regulation pathways 0.3533169471293026 0.2523425872826287 0.8007762730418941 1.0 0.963746726442211 10 P04899,P08754,P10644 3 +Ras signaling 0.3246105144661668 0.2502014131354784 0.8024315924810659 1.0 0.963746726442211 16 P61020,P31751,P11233 3 +Intraflagellar transport proteins binding to dynein 0.4183150971731158 0.2376703222471867 0.8121368035738608 1.0 0.967150467326548 5 Q9BW83 1 +Complement system in neuronal development and plasticity 0.4003797899737618 0.22283452936012 0.8236642930515852 1.0 0.9788474207279708 6 Q9NR28 1 +Serotonin htr1 group and fos pathway 0.4245973424476608 0.2081290477165091 0.8351282069500994 1.0 0.986344837015138 4 P04899 1 +Atm signaling in development and disease 0.308091904044934 0.1982964130019575 0.842813157978721 1.0 0.9913417063110366 20 Q14739 1 +Glycerolipids and glycerophospholipids 0.4935755352357899 0.1840097080991755 0.8540058390061791 1.0 0.9948981306505188 3 Q9UG56 1 +Myometrial relaxation and contraction pathways 0.3118113380673716 0.1827630030939309 0.8549839788615374 1.0 0.9948981306505188 16 Q04917,P78417,P10644,P61981,P27348 5 +Mthfr deficiency 0.3790408931722919 0.1627869225195113 0.8706862052362805 1.0 1.0 6 P35790 1 +Tnfalpha signaling pathway 0.3185784771625526 0.1571909993525249 0.8750943215960039 1.0 1.0 12 P62993,Q9NR28 2 +Endoplasmic reticulum stress response in coronavirus infection 0.3979591836734643 0.1465558119865373 0.8834826338947193 1.0 1.0 4 P19525,P62136,P05198 3 +Endothelin pathways 0.3676590309467765 0.1336326948624389 0.8936930292943839 1.0 1.0 6 P00403 1 +Allograft rejection 0.3395377432004577 0.1109877280760922 0.9116260781824476 1.0 1.0 7 P10321,P08183 2 +Copper homeostasis 0.3557880954465461 0.1054758577157575 0.9159982258685316 1.0 1.0 6 Q658P3,O75880,P05067 3 +Iron metabolism in placenta 0.4380813191851682 0.0917868630337402 0.9268673817789288 1.0 1.0 3 Q658P3 1 +Novel intracellular components of rigilike receptor rlr pathway 0.3572886892609289 0.090919603423651 0.927556473425846 1.0 1.0 5 Q13546,Q92841,Q13573,O00571 4 +Vitamin d receptor pathway 0.3120897812741542 0.0869505655664309 0.9307108061745484 1.0 1.0 8 P49427,P04080,P08183 3 +Disruption of postsynaptic signaling by cnv 0.3253870228075386 0.0757077613951649 0.9396516010177802 1.0 1.0 7 Q14168,Q06787 2 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["15q112 copy number variation syndrome", "15q133 copy number variation syndrome", "16p112 distal deletion syndrome", "16p112 proximal deletion syndrome", "1q211 copy number variation syndrome", "22q112 copy number variation syndrome", "3q29 copy number variation syndrome", "4hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression", "7oxoc and 7betahc pathways", "7q1123 copy number variation syndrome", "Acetylcholine synthesis", "Acquired partial lipodystrophy barraquersimons syndrome", "Acute viral myocarditis", "Adipogenesis", "Aerobic glycolysis", "Aflatoxin b1 metabolism", "Agerage pathway", "Airway smooth muscle cell contraction", "Alanine and aspartate metabolism", "Allograft rejection", "Alpha 6 beta 4 signaling pathway", "Alternative pathway of fetal androgen synthesis", "Alzheimers disease", "Alzheimers disease and mirna effects", "Amino acid metabolism", "Amino acid metabolism pathway excerpt histidine catabolism extension", "Ampactivated protein kinase ampk signaling", "Amyotrophic lateral sclerosis als", "Androgen receptor signaling pathway", "Angiopoietinlike protein 8 regulatory pathway", "Angiotensin ii receptor type 1 pathway", "Antiviral and antiinflammatory effects of nrf2 on sarscov2 pathway", "Apoptosis", "Apoptosis modulation and signaling", "Apoptosis modulation by hsp70", "Apoptosisrelated network due to altered notch3 in ovarian cancer", "Arachidonate epoxygenase epoxide hydrolase", "Arrhythmogenic right ventricular cardiomyopathy", "Aryl hydrocarbon receptor pathway wp2586", "Aryl hydrocarbon receptor pathway wp2873", "Aspirin and mirnas", "Atm signaling in development and disease", "Atm signaling pathway", "Atr signaling", "Autophagy", "Autosomal recessive osteopetrosis pathways", "B cell receptor signaling pathway", "Base excision repair", "Bdnftrkb signaling", "Benzene metabolism", "Benzoapyrene metabolism", "Bile acids synthesis and enterohepatic circulation", "Biogenic amine synthesis", "Biomarkers for pyrimidine metabolism disorders", "Biomarkers for urea cycle disorders", "Biotin metabolism including iems", "Bladder cancer", "Bmp signaling in eyelid development", "Bmp2wnt4foxo1 pathway in primary endometrial stromal cell differentiation", "Brainderived neurotrophic factor bdnf signaling pathway", "Breast cancer pathway", "Burn wound healing", "Calcium regulation in cardiac cells", "Caloric restriction and aging", "Camkk2 pathway", "Cancer immunotherapy by pd1 blockade", "Cannabinoid receptor signaling", "Cardiac hypertrophic response", "Cardiac progenitor differentiation", "Ccl18 signaling pathway", "Cell cycle", "Cell differentiation expanded index", "Cell differentiation index", "Cell migration and invasion through p75ntr", "Cells and molecules involved in local acute inflammatory response", "Cellular proteostasis", "Cerebral organic acidurias including diseases", "Chemokine signaling pathway", "Cholesterol biosynthesis pathway", "Cholesterol biosynthesis with skeletal dysplasias", "Cholesterol metabolism with bloch and kandutschrussell pathways", "Chromosomal and microsatellite instability in colorectal cancer", "Ciliary landscape", "Ciliopathies", "Circadian rhythm genes", "Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism", "Clear cell renal cell carcinoma pathways", "Codeine and morphine metabolism", "Cohesin complex cornelia de lange syndrome", "Common pathways underlying drug addiction", "Complement and coagulation cascades", "Complement system", "Complement system in neuronal development and plasticity", "Congenital generalized lipodystrophy cgl", "Constitutive androstane receptor pathway", "Control of immune tolerance by vasoactive intestinal peptide", "Copper homeostasis", "Cori cycle", "Corticotropinreleasing hormone signaling pathway", "Cysteine and methionine catabolism", "Cytoplasmic ribosomal proteins", "Cytosine methylation", "Cytosolic dnasensing pathway", "Ddx1 as a regulatory component of the drosha microprocessor", "Degradation pathway of sphingolipids including diseases", "Deregulation of rab and rab effector genes in bladder cancer", "Development of pulmonary dendritic cells and macrophage subsets", "Development of ureteric collection system", "Disorders of folate metabolism and transport", "Disruption of postsynaptic signaling by cnv", "Dna damage response", "Dna damage response only atm dependent", "Dna irdamage and cellular response via atr", "Dna irdouble strand breaks and cellular response via atm", "Dna mismatch repair", "Dna repair pathways full network", "Dna replication", "Dopamine metabolism", "Dopaminergic neurogenesis", "Drug induction of bile acid pathway", "Dual hijack model of vif in hiv infection", "Ebola virus infection in host", "Ebsteinbarr virus lmp1 signaling", "Ectoderm differentiation", "Effect of progerin on genes involved in hutchinsongilford progeria syndrome", "Egfegfr signaling pathway", "Egfr tyrosine kinase inhibitor resistance", "Eicosanoid metabolism via cyclooxygenases cox", "Eicosanoid metabolism via lipooxygenases lox", "Eicosanoid synthesis", "Electron transport chain oxphos system in mitochondria", "Embryonic stem cell pluripotency pathways", "Endochondral ossification", "Endochondral ossification with skeletal dysplasias", "Endoderm differentiation", "Endometrial cancer", "Endoplasmic reticulum stress response in coronavirus infection", "Endothelin pathways", "Energy metabolism", "Envelope proteins and their potential roles in edmd physiopathology", "Epithelial to mesenchymal transition in colorectal cancer", "Epo receptor signaling", "Erbb signaling pathway", "Erk pathway in huntingtons disease", "Estrogen metabolism", "Estrogen receptor pathway", "Estrogen signaling pathway", "Ethanol effects on histone modifications", "Ethanol metabolism production of ros by cyp2e1", "Eukaryotic transcription initiation", "Exerciseinduced circadian regulation", "Exrna mechanism of action and biogenesis", "Extracellular vesiclemediated signaling in recipient cells", "Extracellular vesicles in the crosstalk of cardiac cells", "Factors and pathways affecting insulinlike growth factor igf1akt signaling", "Familial hyperlipidemia type 1", "Familial hyperlipidemia type 3", "Familial hyperlipidemia type 4", "Familial hyperlipidemia type 5", "Familial partial lipodystrophy fpld", "Farnesoid x receptor pathway", "Fas ligand pathway and stress induction of heat shock proteins", "Fatty acid betaoxidation", "Fatty acid biosynthesis", "Fatty acid omegaoxidation", "Fatty acid transporters", "Fbxl10 enhancement of maperk signaling in diffuse large bcell lymphoma", "Ferroptosis", "Fgfr3 signaling in chondrocyte proliferation and terminal differentiation", "Fibrin complement receptor 3 signaling pathway", "Fluoroacetic acid toxicity", "Fluoropyrimidine activity", "Focal adhesion", "Focal adhesion pi3kaktmtorsignaling pathway", "Folate metabolism", "Folatealcohol and cancer pathway hypotheses", "Follicle stimulating hormone fsh signaling pathway", "Foxa2 pathway", "Foxp3 in covid19", "Fragile x syndrome", "Fto obesity variant mechanism", "G protein signaling pathways", "G1 to s cell cycle control", "G13 signaling pathway", "Gaba metabolism aka ghb", "Gaba receptor signaling", "Gammaglutamyl cycle for the biosynthesis and degradation of glutathione including diseases", "Ganglio sphingolipid metabolism", "Gastric cancer network 1", "Gastric cancer network 2", "Gastrin signaling pathway", "Gdnfret signaling axis", "Genes controlling nephrogenesis", "Genes related to primary cilium development based on crispr", "Glial cell differentiation", "Glioblastoma signaling pathways", "Glucocorticoid receptor pathway", "Glucuronidation", "Glutathione metabolism", "Glycerolipids and glycerophospholipids", "Glycerophospholipid biosynthetic pathway", "Glycogen synthesis and degradation", "Glycolysis and gluconeogenesis", "Glycolysis in senescence", "Glycosaminoglycan degradation", "Glycosylation and related congenital defects", "Gpcrs class a rhodopsinlike", "Gpr143 in melanocytes and retinal pigment epithelium cells", "H19 action rbe2f1 signaling and cdkbetacatenin activity", "Hair follicle development cytodifferentiation part 3 of 3", "Hair follicle development organogenesis part 2 of 3", "Head and neck squamous cell carcinoma", "Heart development", "Hedgehog signaling pathway wp4249", "Hedgehog signaling pathway wp47", "Hematopoietic stem cell gene regulation by gabp alphabeta complex", "Heme biosynthesis", "Hepatitis b infection", "Hepatitis c and hepatocellular carcinoma", "Hepatocyte growth factor receptor signaling", "Hereditary leiomyomatosis and renal cell carcinoma pathway", "Hif1a and pparg regulation of glycolysis", "Hijack of ubiquitination by sarscov2", "Hippo signaling regulation pathways", "Hippomerlin signaling dysregulation", "Hippoyap signaling pathway", "Histone modifications", "Homologous recombination", "Hostpathogen interaction of human coronaviruses apoptosis", "Hostpathogen interaction of human coronaviruses autophagy", "Hostpathogen interaction of human coronaviruses interferon induction", "Hostpathogen interaction of human coronaviruses mapk signaling", "Hypertrophy model", "Hypothesized pathways in pathogenesis of cardiovascular disease", "Hypothetical craniofacial development pathway", "Id signaling pathway", "Il1 signaling pathway", "Il10 antiinflammatory signaling pathway", "Il17 signaling pathway", "Il18 signaling pathway", "Il2 signaling pathway", "Il3 signaling pathway", "Il4 signaling pathway", "Il5 signaling pathway", "Il6 signaling pathway", "Il7 signaling pathway", "Il9 signaling pathway", "Imatinib and chronic myeloid leukemia", "Immune response to tuberculosis", "Inclusion body myositis", "Influence of laminopathies on wnt signaling", "Inhibition of exosome biogenesis and secretion by manumycin a in crpc cells", "Initiation of transcription and translation elongation at the hiv1 ltr", "Insulin signaling", "Insulin signaling in adipocytes diabetic condition", "Insulin signaling in adipocytes normal condition", "Integrated cancer pathway", "Integrinmediated cell adhesion", "Interactions between immune cells and micrornas in tumor microenvironment", "Interactions between loxl4 and oxidative stress pathway", "Interactions of natural killer cells in pancreatic cancer", "Interactome of polycomb repressive complex 2 prc2", "Interferon type i signaling pathways", "Interleukin1 il1 structural pathway", "Interleukin1 induced activation of nfkb", "Interleukin11 signaling pathway", "Intracellular trafficking proteins involved in cmt neuropathy", "Intraflagellar transport proteins binding to dynein", "Irinotecan pathway", "Iron metabolism in placenta", "Joubert syndrome", "Kallmann syndrome", "Kennedy pathway from sphingolipids", "Ketogenesis and ketolysis", "Ketone bodies synthesis and degradation", "Kininkallikrein pathway", "Kisspeptinkisspeptin receptor system in the ovary", "Kit receptor signaling pathway", "Krebs cycle disorders", "Kynurenine pathway and links to cell senescence", "Leptin and adiponectin", "Leptin signaling pathway", "Leptininsulin signaling overlap", "Leukocyteintrinsic hippo pathway functions", "Linoleic acid metabolism affected by coronavirus infection", "Lipid metabolism pathway", "Liver x receptor pathway", "Lncrna in canonical wnt signaling and colorectal cancer", "Lncrnamediated mechanisms of therapeutic resistance", "Lung fibrosis", "Male infertility", "Malignant pleural mesothelioma", "Mammalian disorder of sexual development", "Mammary gland development pathway embryonic development stage 1 of 4", "Mammary gland development pathway involution stage 4 of 4", "Mammary gland development pathway pregnancy and lactation stage 3 of 4", "Mammary gland development pathway puberty stage 2 of 4", "Map3k1 role in promoting and blocking gonadal determination", "Mapk cascade", "Mapk pathway in congenital thyroid cancer", "Mapk signaling pathway", "Matrix metalloproteinases", "Mbdnf and probdnf regulation of gaba neurotransmission", "Measles virus infection", "Mechanoregulation and pathology of yaptaz via hippo and nonhippo mechanisms", "Mecp2 and associated rett syndrome", "Melanoma", "Melatonin metabolism and effects", "Mesodermal commitment pathway", "Met in type 1 papillary renal cell carcinoma", "Metabolic pathway of ldl hdl and tg including diseases", "Metabolic reprogramming in colon cancer", "Metabolism of alphalinolenic acid", "Metabolism of spingolipids in er and golgi apparatus", "Metapathway biotransformation phase i and ii", "Metastatic brain tumor", "Methionine de novo and salvage pathway", "Methionine metabolism leading to sulfur amino acids and related disorders", "Methylation pathways", "Mevalonate arm of cholesterol biosynthesis pathway", "Mevalonate pathway", "Mfap5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement", "Microglia pathogen phagocytosis pathway", "Microrna for targeting cancer growth and vascularization in glioblastoma", "Microrna network associated with chronic lymphocytic leukemia", "Micrornas in cardiomyocyte hypertrophy", "Microtubule cytoskeleton regulation", "Mir124 predicted interactions with cell cycle and differentiation", "Mir517 relationship with arcn1 and usp1", "Mirna biogenesis", "Mirna regulation of dna damage response", "Mirna regulation of p53 pathway in prostate cancer", "Mirna regulation of prostate cancer signaling pathways", "Mirnas involved in dna damage response", "Mitochondrial complex i assembly model oxphos system", "Mitochondrial complex ii assembly", "Mitochondrial complex iii assembly", "Mitochondrial complex iv assembly", "Mitochondrial fatty acid synthesis pathway", "Mitochondrial gene expression", "Mitochondrial immune response to sarscov2", "Mitochondrial long chain fatty acid betaoxidation", "Modulators of tcr signaling and t cell activation", "Monoamine transport", "Mrna processing", "Mrna protein and metabolite inducation pathway by cyclosporin a", "Mthfr deficiency", "Myd88 distinct inputoutput pathway", "Myometrial relaxation and contraction pathways", "Nad biosynthetic pathways", "Nad metabolism", "Nad metabolism in oncogeneinduced senescence and mitochondrial dysfunctionassociated senescence", "Nad metabolism sirtuins and aging", "Nanomaterial induced apoptosis", "Nanoparticle triggered autophagic cell death", "Nanoparticle triggered regulated necrosis", "Nanoparticlemediated activation of receptor signaling", "Ncrnas involved in stat3 signaling in hepatocellular carcinoma", "Ncrnas involved in wnt signaling in hepatocellular carcinoma", "Nephrogenesis", "Nephrotic syndrome", "Netrinunc5b signaling pathway", "Network map of sarscov2 signaling pathway", "Neural crest cell migration during development", "Neural crest cell migration in cancer", "Neural crest differentiation", "Neurodegeneration with brain iron accumulation nbia subtypes pathway", "Neuroinflammation", "Neuroinflammation and glutamatergic signaling", "Nicotine effect on dopaminergic neurons", "Nipbl role in dna damage cornelia de lange syndrome", "Nitric oxide metabolism in cystic fibrosis", "Nocgmppkg mediated neuroprotection", "Nonalcoholic fatty liver disease", "Nongenomic actions of 125 dihydroxyvitamin d3", "Nonhomologous end joining", "Nonsmall cell lung cancer", "Notch signaling", "Notch signaling pathway", "Notch1 regulation of endothelial cell calcification", "Novel intracellular components of rigilike receptor rlr pathway", "Nrf2 pathway", "Nrf2are regulation", "Nrp1triggered signaling pathways in pancreatic cancer", "Nsp1 from sarscov2 inhibits translation initiation in the host cell", "Nuclear receptors in lipid metabolism and toxicity", "Nuclear receptors metapathway", "Nucleotide excision repair", "Nucleotide excision repair in xeroderma pigmentosum", "Nucleotide metabolism", "Nucleotidebinding oligomerization domain nod pathway", "Oligodendrocyte specification and differentiation leading to myelin components for cns", "Omega3 omega6 fatty acid synthesis", "Omega9 fatty acid synthesis", "Oncostatin m signaling pathway", "Onecarbon metabolism", "Onecarbon metabolism and related pathways", "Orexin receptor pathway", "Osteoblast differentiation and related diseases", "Osteoclast signaling", "Osteopontin signaling", "Osx and mirnas in tooth development", "Ovarian infertility", "Overlap between signal transduction pathways contributing to lmna laminopathies", "Overview of nanoparticle effects", "Oxidation by cytochrome p450", "Oxidative damage response", "Oxidative phosphorylation", "Oxidative stress response", "Oxysterols derived from cholesterol", "P38 mapk signaling pathway", "P53 transcriptional gene network", "Pancreatic adenocarcinoma pathway", "Parkinsons disease pathway", "Parkinubiquitin proteasomal system pathway", "Pathogenesis of sarscov2 mediated by nsp9nsp10 complex", "Pathogenic escherichia coli infection", "Pathways affected in adenoid cystic carcinoma", "Pathways of nucleic acid metabolism and innate immune sensing", "Pdgf pathway", "Pdgfrbeta pathway", "Pentose phosphate metabolism", "Pentose phosphate pathway in senescent cells", "Peptide gpcrs", "Peroxiredoxin 2 induced ovarian failure", "Phase i biotransformations non p450", "Phosphodiesterases in neuronal function", "Phosphoinositides metabolism", "Photodynamic therapyinduced ap1 survival signaling", "Photodynamic therapyinduced hif1 survival signaling", "Photodynamic therapyinduced nfe2l2 nrf2 survival signaling", "Photodynamic therapyinduced unfolded protein response", "Physicochemical features and toxicityassociated pathways", "Physiological and pathological hypertrophy of the heart", "Pi3kakt signaling pathway", "Pi3kaktmtor signaling pathway and therapeutic opportunities", "Pi3kaktmtor vitd3 signaling", "Pilocytic astrocytoma", "Pkcgamma calcium signaling pathway in ataxia", "Ppar signaling pathway", "Pparalpha pathway", "Praderwilli and angelman syndrome", "Pregnane x receptor pathway", "Preimplantation embryo", "Primary focal segmental glomerulosclerosis fsgs", "Prion disease pathway", "Progeriaassociated lipodystrophy", "Prolactin signaling pathway", "Prostaglandin and leukotriene metabolism in senescence", "Prostaglandin synthesis and regulation", "Proteasome degradation", "Proteoglycan biosynthesis", "Proximal tubule transport", "Ptf1a related regulatory pathway", "Purine metabolism", "Purine metabolism and related disorders", "Purinergic signaling", "Pyrimidine metabolism", "Pyrimidine metabolism and related diseases", "Quercetin and nfkb ap1 induced apoptosis", "Rac1pak1p38mmp2 pathway", "Rala downstream regulated genes", "Ranklrank signaling pathway", "Ras and bradykinin pathways in covid19", "Ras signaling", "Regucalcin in proximal tubule epithelial kidney cells", "Regulation of actin cytoskeleton", "Regulation of apoptosis by parathyroid hormonerelated protein", "Regulation of sister chromatid separation at the metaphaseanaphase transition", "Regulation of wnt bcatenin signaling by small molecule compounds", "Regulatory circuits of the stat3 signaling pathway", "Relationship between inflammation cox2 and egfr", "Reninangiotensinaldosterone system raas", "Resistin as a regulator of inflammation", "Retinoblastoma gene in cancer", "Rett syndrome causing genes", "Riboflavin and coq disorders", "Robo4 and vegf signaling pathways crosstalk", "S1p receptor signal transduction", "Sarscov2 and covid19 pathway", "Sarscov2 b117 variant antagonises innate immune activation", "Sarscov2 innate immunity evasion and cellspecific immune response", "Selective expression of chemokine receptors during tcell polarization", "Selenium micronutrient network", "Serine metabolism", "Serotonin and anxiety", "Serotonin htr1 group and fos pathway", "Serotonin receptor 2 and elksrfgata4 signaling", "Serotonin receptor 467 and nr3c signaling", "Serotonin transporter activity", "Signal transduction through il1r", "Sleep regulation", "Small cell lung cancer", "Smc1smc3 role in dna damage cornelia de lange syndrome", "Somatroph axis gh and its relationship to dietary restriction and aging", "Sphingolipid metabolism in senescence", "Sphingolipid metabolism integrated pathway", "Sphingolipid metabolism overview", "Sphingolipid pathway", "Spinal cord injury", "Splicing factor nova regulated synaptic proteins", "Srebf and mir33 in cholesterol and lipid homeostasis", "Srf and mirs in smooth muscle differentiation and proliferation", "Statin inhibition of cholesterol production", "Steroid biosynthesis", "Sterol regulatory elementbinding proteins srebp signaling", "Striated muscle contraction pathway", "Sudden infant death syndrome sids susceptibility pathways", "Sulfation biotransformation reaction", "Supression of hmgb1 mediated inflammation by thbd", "Synaptic signaling pathways associated with autism spectrum disorder", "Synaptic vesicle pathway", "T cell receptor and costimulatory signaling", "Target of rapamycin tor signaling", "Tca cycle aka krebs or citric acid cycle", "Tca cycle and deficiency of pyruvate dehydrogenase complex pdhc", "Tca cycle in senescence", "Tca cycle nutrient use and invasiveness of ovarian cancer", "Tcell activation sarscov2", "Tcell antigen receptor tcr pathway during staphylococcus aureus infection", "Tcell receptor tcr signaling pathway", "Tgfbeta receptor signaling", "Tgfbeta receptor signaling in skeletal dysplasias", "Tgfbeta signaling in thyroid cells for epithelialmesenchymal transition", "Tgfbeta signaling pathway", "Thermogenesis", "Thiamine metabolic pathways", "Thymic stromal lymphopoietin tslp signaling pathway", "Thyroid hormones production and peripheral downstream signaling effects", "Thyroid stimulating hormone tsh signaling pathway", "Tlr4 signaling and tolerance", "Tnfalpha signaling pathway", "Tnfrelated weak inducer of apoptosis tweak signaling pathway", "Tolllike receptor signaling pathway", "Tolllike receptor signaling related to myd88", "Tp53 network", "Transcription cofactors ski and skil protein partners", "Transcription factors regulate mirnas related to cardiac hypertrophy", "Transcriptional activation by nrf2 in response to phytochemicals", "Translation factors", "Translation inhibitors in chronically activated pdgfra cells", "Transsulfuration and onecarbon metabolism", "Transsulfuration pathway", "Triacylglyceride synthesis", "Tryptophan catabolism leading to nad production", "Tryptophan metabolism", "Tumor suppressor activity of smarcb1", "Type 2 papillary renal cell carcinoma", "Type i collagen synthesis in the context of osteogenesis imperfecta", "Type i interferon induction and signaling during sarscov2 infection", "Type ii diabetes mellitus", "Type ii interferon signaling ifng", "Tyrobp causal network in microglia", "Ultraconserved region 339 modulation of tumor suppressor micrornas in cancer", "Unfolded protein response", "Urea cycle and associated pathways", "Urea cycle and metabolism of amino groups", "Urea cycle and related diseases", "Valproic acid pathway", "Vasopressinregulated water reabsorption", "Vegfavegfr2 signaling pathway", "Vitamin a and carotenoid metabolism", "Vitamin b12 disorders", "Vitamin b12 metabolism", "Vitamin b6dependent and responsive disorders", "Vitamin d metabolism", "Vitamin d receptor pathway", "Vitamin dsensitive calcium signaling in depression", "White fat cell differentiation", "Wnt signaling", "Wnt signaling in kidney disease", "Wnt signaling pathway", "Wnt signaling pathway and pluripotency", "Wntbetacatenin signaling pathway in leukemia"], "available_proteins": ["AARS", "AASS", "ABCB1", "ABCC4", "ABCD3", "ABCF1", "ABCF2", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR2", "ACTR3", "ADAM17", "ADAR", "ADH5", "ADI1", "ADK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AKAP1", "AKAP12", "AKAP13", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "AMOT", "ANAPC1", "ANAPC5", "ANAPC7", "ANK3", "ANLN", "ANXA1", "ANXA2", "ANXA6", "AP1G1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "APEX1", "APLP2", "APMAP", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH2", "ARL2", "ARL3", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ATIC", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0D1", "ATP6V1A", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATPIF1", "ATXN10", "ATXN2L", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAT2", "BCL2L12", "BCLAF1", "BLM", "BLVRA", "BPTF", "BRCA1", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "C15orf39", "C1QBP", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAND1", "CAP1", "CAPN1", "CAPN2", "CAPZB", "CARM1", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR2", "CCDC124", "CCDC6", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CDC23", "CDC27", "CDC34", "CDC37", "CDC42", "CDC73", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CEBPZ", "CECR2", "CELF1", "CENPB", "CEP170", "CERS2", "CFL1", "CFL2", "CHAMP1", "CHD4", "CHKA", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIP2A", "CKB", "CLASP1", "CLASP2", "CLIC1", "CLTC", "CLUH", "CMPK1", "CNN2", "CNOT1", "CNOT10", "CNOT6", "CNOT9", "CNP", "COA3", "COLGALT1", "COMT", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPT2", "CRKL", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DARS", "DBNL", "DCAF7", "DCTN1", "DCTN2", "DCTN4", "DCTPP1", "DDB1", "DDOST", "DDX1", "DDX17", "DDX20", "DDX21", "DDX3X", "DDX5", "DDX52", "DDX56", "DEK", "DERL1", "DFFA", "DGCR8", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX29", "DHX36", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJB1", "DNAJC3", "DNAJC7", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DPF2", "DPM1", "DPP9", "DPYSL2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "ECE1", "ECH1", "ECHS1", "ECSIT", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF4A1", "EIF4A2", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "EMD", "EML4", "ENAH", "ENO1", "EPB41", "EPB41L2", "EPHX1", "EPRS", "ERCC2", "ERCC3", "ESD", "ETF1", "ETFA", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC7", "EXOSC7", "EZR", "F11R", "FADS2", "FAF1", "FAH", "FANCI", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FECH", "FEN1", "FGFR1OP", "FH", "FHL1", "FKBP10", "FKBP2", "FKBP4", "FKBP5", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FOXC1", "FSCN1", "FTO", "FUS", "FXR1", "FXR2", "G3BP1", "G6PD", "GALNT1", "GAPDH", "GART", "GBA", "GCC2", "GCDH", "GDI1", "GFPT1", "GGCT", "GGCX", "GGH", "GIGYF2", "GLA", "GLB1", "GLS", "GLUD1", "GM2A", "GNA13", "GNAI2", "GNAI3", "GNPAT", "GNS", "GOT1", "GOT2", "GPD2", "GPI", "GPS1", "GRB2", "GRSF1", "GSK3A", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2I", "GTPBP4", "GUSB", "GYS1", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HADH", "HADHA", "HADHB", "HAT1", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HEBP1", "HELLS", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIF1AN", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMGCS1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HPRT1", "HSD17B10", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HTRA2", "HTT", "HYOU1", "IARS", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP3", "ILF2", "ILK", "IMP3", "IMPDH2", "INF2", "IPO9", "IQGAP1", "IRS4", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIF22", "KIF23", "KIF2C", "KIF4A", "KIF5B", "KLC2", "KLC4", "KMT2A", "KPNA1", "KPNA4", "KPNB1", "KTN1", "L2HGDH", "LARP1", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LEMD3", "LGALS3BP", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LRPPRC", "LRRC59", "LRWD1", "LSM2", "LSS", "LTA4H", "LUC7L", "MACF1", "MAGT1", "MAP1B", "MAP2K1", "MAP4", "MAPRE1", "MAPRE2", "MARCKS", "MARK2", "MARS", "MAT2A", "MAU2", "MBD3", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDC1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MFN2", "MGST2", "MGST3", "MIA3", "MIF", "MKI67", "MMAB", "MOGS", "MORF4L1", "MOV10", "MPI", "MPP2", "MPST", "MRE11", "MRI1", "MRPL19", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTMR6", "MTOR", "MTR", "MYBBP1A", "MYEF2", "MYH10", "MYH9", "MYL6", "MYO1C", "MYO6", "NAA15", "NAA40", "NAA50", "NAGLU", "NAMPT", "NAP1L1", "NAPA", "NARS", "NAT10", "NCAPG", "NCBP1", "NCKAP1", "NCL", "NCSTN", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFAF7", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFCD", "NEU1", "NIPBL", "NKRF", "NME1", "NONO", "NOP2", "NPC1", "NPC2", "NSDHL", "NSF", "NUDC", "NUDT21", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP214", "NUP62", "NUP88", "NUP98", "NXF1", "OAT", "OCLN", "OGDH", "OGT", "OPA1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PAICS", "PAK2", "PAK4", "PAPOLA", "PAPSS1", "PARK7", "PARN", "PARP1", "PARP2", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCM1", "PCNA", "PDCD4", "PDCD6", "PDCD6IP", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA6", "PDLIM5", "PDLIM7", "PDS5A", "PDS5B", "PEBP1", "PECR", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF6", "PHGDH", "PIGT", "PISD", "PKM", "PKN2", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PMPCA", "PNP", "PNPT1", "POLD1", "POLDIP2", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POR", "PPAT", "PPIB", "PPID", "PPIF", "PPM1G", "PPP1CA", "PPP1R10", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PRCC", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PRIM1", "PRIM2", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF3", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSPC1", "PTBP1", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTRH2", "PURA", "PUS1", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QKI", "RAB10", "RAB13", "RAB14", "RAB2A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RAC1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RALA", "RAN", "RANBP1", "RANBP9", "RANGAP1", "RARS", "RBM14", "RBM17", "RBM39", "RBM4", "RBM5", "RBMX", "RCC1", "RCN1", "RDX", "RECQL", "RECQL5", "RETSAT", "REXO2", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RIF1", "RIPK1", "RNASEH2A", "RNASET2", "RNF20", "RNF40", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RTCB", "RTN3", "RTN4", "RUVBL1", "S100A10", "S100A11", "SACM1L", "SAFB", "SAMHD1", "SAP18", "SAR1A", "SARS", "SCAMP2", "SCARB1", "SCARB2", "SCD", "SCO1", "SCP2", "SCRIB", "SDHA", "SDHB", "SEC23A", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEL1L", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SEZ6L2", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SFPQ", "SFSWAP", "SGPL1", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SIN3A", "SIRT2", "SKP1", "SKP2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35B2", "SLC3A2", "SLC6A15", "SLIT2", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMYD3", "SNAP29", "SND1", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SOD2", "SORT1", "SPEN", "SPTAN1", "SPTBN1", "SPTLC1", "SQLE", "SQSTM1", "SRCAP", "SRM", "SRP54", "SRPK1", "SRPK2", "SRRM1", "SRSF1", "SRSF10", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSR4", "STAG2", "STAT3", "STEAP3", "STIP1", "STMN1", "STRAP", "STUB1", "STXBP3", "STXBP4", "SUCLA2", "SUCLG1", "SUCLG2", "SUGT1", "SUPT5H", "SUZ12", "SYNE2", "TACO1", "TALDO1", "TAP1", "TARDBP", "TBC1D4", "TBCA", "TBL2", "TCP1", "TDP2", "TECR", "TELO2", "TFAM", "TFRC", "THRAP3", "TIGAR", "TIMELESS", "TIMMDC1", "TIPRL", "TJP1", "TJP2", "TK1", "TKT", "TLN1", "TMED10", "TMEM126B", "TMEM43", "TMOD3", "TMPO", "TMPO", "TNKS1BP1", "TNPO1", "TOLLIP", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOPBP1", "TOR1AIP1", "TP53", "TP53BP1", "TPI1", "TPM3", "TPP1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TSC2", "TSG101", "TTC19", "TTC21B", "TTC26", "TTK", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TXNDC5", "TXNRD1", "TYMS", "U2AF2", "UBA1", "UBA3", "UBAP2L", "UBE2L3", "UBE2N", "UBR5", "UBTF", "UCHL5", "UFD1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNG", "UPF1", "UQCR10", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USMG5", "USP10", "USP5", "USP7", "USP8", "USP9X", "UTRN", "VAPA", "VAPB", "VARS1", "VBP1", "VCL", "VDAC1", "VDAC2", "VDAC3", "VIM", "VPS16", "VPS18", "VPS33A", "WAPL", "WARS", "WDHD1", "WDR1", "WDR5", "WFS1", "XAB2", "XPO1", "XPO5", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H15", "ZFR", "ZFYVE16", "ZMPSTE24", "ZNF281", "ZNF318", "ZYX"], "leading_proteins": ["ABCB1", "ABCC4", "ACTN4", "AIFM1", "AKT2", "ALDH1A2", "APMAP", "APP", "ASAH1", "ASNA1", "ATP5B", "ATP5F1", "ATP5H", "ATP5J2", "ATP5L", "ATP6AP1", "ATPIF1", "ATXN2L", "BTF3", "C1QBP", "CBX1", "CBX3", "CDC34", "CDC37", "CERS2", "CHKA", "CNOT10", "CNOT9", "COMT", "COPS4", "COPS5", "COPS8", "COX2", "COX5A", "COX7A2", "CPT2", "CRTAP", "CSNK1A1", "CSTB", "CTSA", "CYP51A1", "DCAF7", "DDX17", "DDX3X", "DHCR24", "DHCR7", "DHFR", "DIABLO", "DYNC1I2", "EIF2AK2", "EIF2S1", "EIF3E", "EIF3H", "EIF5", "EIF6", "EPHX1", "ERCC2", "ETFA", "ETFDH", "EXO1", "EXOC3", "EXOSC7", "FKBP2", "FMR1", "GLA", "GLB1", "GM2A", "GNAI2", "GNAI3", "GNS", "GRB2", "GSTO1", "GUSB", "HADH", "HADHA", "HLA-C", "HMGCL", "HMOX1", "HSPB1", "HTRA2", "ICMT", "IDH2", "IFT27", "KDSR", "KLC4", "KMT2A", "LBR", "LSS", "MAPRE2", "MGST3", "MPP2", "MYL6", "NAGLU", "NAMPT", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFB3", "NDUFS2", "NPC2", "NUDC", "P4HA1", "P4HA2", "PARP2", "PFDN5", "PFN1", "PGRMC2", "PISD", "PON2", "PPID", "PPP1CA", "PRCC", "PRKACA", "PRKAR1A", "PRMT1", "PSMA6", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMD10", "PSMD8", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PXMP2", "RAB14", "RAB5A", "RAB5B", "RALA", "RBM14", "RFC2", "RIPK1", "RTN3", "SCARB1", "SCARB2", "SCO1", "SIRT2", "SLC19A1", "SLC25A15", "SLC25A20", "SLC35B2", "SLC6A15", "SNAP29", "SNW1", "SORT1", "SQSTM1", "STEAP3", "SUPT5H", "TFAM", "TMEM126B", "TTC19", 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sha256:78b2a76df8ba5bde0d73289d0a1b74b5a9e4e9a7439805f3fa1671dbf0a45b72 +size 137697 diff --git a/opencell_localization/basic/plot_3.png b/opencell_localization/basic/plot_3.png new file mode 100644 index 0000000000000000000000000000000000000000..3fd8484d55f100e2b0d1a65aebc979cd91600762 --- /dev/null +++ b/opencell_localization/basic/plot_3.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:06da3a771e5b82cd988f30ce50c5e871d4d6382fc567d8fe96adfd3a71fe5ae4 +size 141969 diff --git a/opencell_localization/consensus.joblib b/opencell_localization/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..5f9d5cb26e5c456ca16c2a05b97738a2143b7b5d --- /dev/null +++ b/opencell_localization/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:cc54f81512489bfdada8377f040ee9fcb8dad587493179766d9d9db4f28ba94c +size 56019 diff --git a/opencell_localization/df_merge.tsv b/opencell_localization/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..a15b555f60504c3a9dca0e3cb487c6fbbf4a5aa9 --- /dev/null +++ b/opencell_localization/df_merge.tsv @@ -0,0 +1,3 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +er 24 69 2.407235220619263 0.0160738132540103 29.17233009708738 87.61893203883496 1.3358083950399515 0.3757472714196316 13.465054065187209 8.223393744963309 2.0429537263872786 0.4010648005920765 1.0 0.148662677751522 0.0122769556361771 0.0215982709727899 0.0004520475487609 +mitochondria 7 11 1.9792562780765453 0.0477871595050176 4.441747572815534 10.567961165048544 1.1937677940164793 0.2159787381789819 2.254231157409949 0.7391563798220593 1.4011905974754153 0.2980089661914649 1.0 0.0017062060788896 0.0067896670197663 0.0033170374819039 7.565932780436378e-07 diff --git a/opencell_localization/metrics.json b/opencell_localization/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..3e07f316f0e1468fa3279ee7bc5bee9755bc1158 --- /dev/null +++ b/opencell_localization/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2454, + "annotations_size": 17, + "title": "Average number of proteins per term", + "value": 78.6470588235294 +} \ No newline at end of file diff --git a/opencell_localization/paths.json b/opencell_localization/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..af60ae9eefb5ec563079392a0ec86254523fe990 --- /dev/null +++ b/opencell_localization/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/opencell_localization/fragment/C340/C340_val_log2fc"} \ No newline at end of file diff --git a/opencell_localization/result.tsv b/opencell_localization/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..d807f67811f26e886e4635a81ce0048c58abde9f --- /dev/null +++ b/opencell_localization/result.tsv @@ -0,0 +1,5 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +er 0.4707683740070504 2.407235220619263 0.0160738132540103 0.2407884129522534 0.136627412659088 69 Q9NQC3,Q9Y3C8,Q06136,Q969V3,P49755,Q9Y5M8,Q15392,Q9NR31,Q14739,O00264,P48651,Q16850,Q15738,O75340,P48449,P18085,Q15041,Q8N4V1,O15173,Q9UM00,Q969Q5,O96005,Q8WUX9,Q9Y487 24 +mitochondria 0.6829329407297522 1.9792562780765457 0.0477871595050176 0.5650107030560289 0.2707939038617667 11 Q8IWA4,P45880,O95140,P21796,Q9Y277,Q15388,Q9NR31 7 +vesicles 0.3334555330715834 1.015482091589707 0.3098760789265828 0.998172908151284 0.6966263860139685 127 Q06136,Q969V3,P31751,P61923,Q9BQC3,Q15392,Q15904,Q13501,P61421,Q8IXU6,P60903,Q5VW38,P61020,P62820,Q15738,Q6NT16,P41440,P48449,Q9H2J7,O15173,Q93050,P11279,O96005 23 +golgi 0.3084391331116859 0.4459292354513474 0.6556483633072645 0.9999999865402628 0.6966263860139685 47 Q8IXU6,Q5VW38,P18085,Q9H8Y8,P62820,P61923,P40616,Q9UM00,Q9Y487,Q15904 10 diff --git a/opencell_localization/selections.json b/opencell_localization/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..20377ba0338f75f66a70821223d7697353fdffa7 --- /dev/null +++ b/opencell_localization/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["big_aggregates", "cell_contact", "centrosome", "chromatin", "cytoplasmic", "cytoskeleton", "er", "focal_adhesions", "golgi", "membrane", "mitochondria", "nuclear_membrane", "nuclear_punctae", "nucleolus_fc_dfc", "nucleolus_gc", "nucleoplasm", "vesicles"], "available_proteins": ["AATF", "ABCE1", "ACLY", "ACTN1", "ACTN4", "ACTR2", "AHCY", "AHSA1", "AKAP12", "AKAP13", "AKAP8L", "AKR1A1", "AKT1S1", "AKT2", "ALDH9A1", "ANAPC16", "ANKRD17", "ANXA11", "AP2B1", "APLP2", "ARF4", "ARFGAP1", "ARID1A", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARPC3", "ATG4B", "ATL2", "ATP1A1", "ATP2B1", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATP6V1H", "ATXN10", "ATXN2L", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAP31", "BLM", "BLVRA", "BMS1", "BOP1", "BRD2", "BTF3", "BUB1B", "BUD23", "BYSL", "C1orf123", "CAD", "CALD1", "CAMK2G", "CANX", "CAPRIN1", "CAPZB", "CBX1", "CCAR1", "CCDC47", "CCDC86", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC23", "CDC27", "CDC37", "CDC42", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CEP170", "CHMP3", "CHMP7", "CKAP2", "CKAP4", "CKAP5", "CKB", "CLASP1", "CLASP2", "CLINT1", "CLNS1A", "CLPTM1", "CLTC", "CNN2", "COIL", "COMMD2", "COPA", "COPB2", "COPG1", "COPG2", "COPZ1", "CORO1B", "CORO1C", "CPSF6", "CSE1L", "CSK", "CSNK1A1", "CSNK2B", "CTBP1", "CTBP2", "CTNNB1", "CTNNBL1", "CTPS1", "CTTN", "CYB5R3", "CYP51A1", "DAD1", "DBNL", "DCTN2", "DDB1", "DDOST", "DDX21", "DDX39B", "DDX47", "DDX5", "DDX56", "DDX6", "DHCR24", "DHX37", "DHX9", "DIAPH1", "DKC1", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC11", "DNAJC2", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DOCK7", "DPH2", "DRG1", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "EBNA1BP2", "EDC3", "EDC4", "EEF1G", "EFTUD2", "EIF2AK2", "EIF3B", "EIF3E", "EIF3G", "EIF3I", "EIF3K", "EIF3M", "EIF4A1", "EIF4A3", "EIF5", "EMC1", "EMC2", "EMC4", "EMC7", "EMG1", "ENO1", "ENY2", "ESD", "ESYT1", "EWSR1", "EZR", "FASN", "FAU", "FBL", "FDPS", "FKBP5", "FKBP8", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAK", "GAPDH", "GAR1", "GBF1", "GDI1", "GDI2", "GET4", "GNL2", "GNL3", "GORASP2", "GPR107", "GRB2", "GSK3A", "GSK3B", "GSPT1", "GTPBP4", "GYS1", "H1F0", "HDAC1", "HDAC2", "HEATR3", "HLA-A", "HMGA1", "HMGB2", "HMGCS1", "HNRNPA0", "HNRNPC", "HNRNPD", "HNRNPH1", "HNRNPL", "HNRNPU", "HSP90AA1", "HSP90AB1", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPB1", "HSPBP1", "HSPH1", "IDI1", "IGF2BP1", "IGF2BP3", "ILF3", "ILK", "IMP3", "INTS14", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IST1", "KDSR", "KEAP1", "KIAA0368", "KIF11", "KIF22", "KIF2A", "KIF2C", "KIF4A", "KIF5B", 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b/panther_protein_class/basic/plot_9.png new file mode 100644 index 0000000000000000000000000000000000000000..d08d5fbb5f0a5000ec6a8435b0b7bad03f40fc4c --- /dev/null +++ b/panther_protein_class/basic/plot_9.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:dad0f7b6d2c038c3946e4de242857fffe91736489a9cf5fe535a7e661f15e104 +size 140320 diff --git a/panther_protein_class/consensus.joblib b/panther_protein_class/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..0b22fc122478a18c1fce4102c403e6766f46fbe0 --- /dev/null +++ b/panther_protein_class/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:da8d33f9a4d95295cf33466dca20c340600f6f28ec863e2c790861a7a97fe70d +size 66779 diff --git a/panther_protein_class/df_merge.tsv b/panther_protein_class/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..cf98b1e76d879b53f97d93cb91c17bb05d65c1b8 --- /dev/null +++ b/panther_protein_class/df_merge.tsv @@ -0,0 +1,11 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +transporter 13 49 3.334200619646625 0.0008554493350083 16.281553398058254 57.34708737864078 1.7781248355514696 0.2510912048406951 6.627271511266295 3.5084386843827997 1.4364723564792363 0.3433005081320681 1.0 0.0023437820755387 0.0055454664314879 0.0001174248355497 0.000142515224654 +oxidoreductase 9 33 2.8493346335171275 0.0043810774034169 12.558252427184469 43.60436893203884 0.9664652969079414 0.3656199292680728 5.072676172192643 3.8442089013841825 1.3118377214144643 0.3470065139863294 1.0 0.0761999214167486 0.0022662731163913 9.306210287408808e-05 0.0155926932163814 +serine protease 4 17 2.731206457029482 0.0063102927261837 5.662621359223301 17.516990291262136 1.1445634795625386 0.1820139001244477 2.0809494011218104 1.6626107291843584 1.568325484830445 0.2384821649427795 1.0 8.508689216563006e-05 0.0001059830796752 0.0063027604866002 0.0084488258349492 +metalloprotease 9 24 2.6030979290159806 0.0092385560548227 8.58495145631068 26.398058252427184 1.4262736372921438 0.246779453311036 3.321022586051017 1.6463540525991265 1.1083706824215755 0.2918245458017476 1.0 0.2295798469686227 0.0001691618749341 4.084602018344024e-05 0.0002126277231718 +oxygenase 2 6 2.408685718979054 0.0160100781987857 3.138349514563106 6.771844660194175 1.5409868347565758 0.1477866581414416 1.2914149665013366 1.041089559555361 1.2379399582807478 0.2357869798067575 0.0047024181847317 0.0058373227860703 0.0015498580582828 0.0193169154759243 0.1058637057364033 +reductase 8 27 2.2009018105879146 0.0277429757371721 6.944174757281553 30.37621359223301 0.2358909849987802 0.4445668095849227 2.9427036720503694 2.2407776980866343 1.072078278953933 0.2941315836599033 1.0 0.0345877004093447 0.0028574061260132 1.3890732957490578e-05 0.0023681951140858 +primary active transporter 4 20 2.0954596938750414 0.0361301478485289 8.614077669902912 23.45631067961165 1.2392440710771837 0.271771563990288 4.792195908457348 3.1431129799052804 1.4794913205770832 0.3014776193450941 1.0 0.0356328568827733 0.1215022402141297 0.0166327696461577 0.0762942115427641 +membrane trafficking regulatory protein 3 14 2.0875818210434884 0.0368355732554868 4.949029126213592 18.78640776699029 1.0645815505395402 0.2320552342124929 2.3097144002673033 2.893415643517755 1.4460865220385617 0.2677048300346334 1.0 0.225839943305071 0.0146485330026984 0.0385372375494843 0.1096897501341629 +secondary carrier transporter 5 10 2.0135510425851684 0.0440566908823805 6.104368932038835 14.6626213592233 1.264699085385324 0.2718921136589474 3.483843477892234 2.781747184831951 1.2916784116683784 0.322278600042778 1.0 1.0 0.5010041483550427 0.8244940603927083 0.2548787269191424 +calmodulin-related 6 11 2.011617457584454 0.0442602776952736 5.053398058252427 12.385922330097088 1.3935892727836532 0.1814075830019033 2.0222219603900085 1.786979844553702 1.206053991839631 0.2252292235861566 1.0 0.0063255491406275 0.02421661276018 2.2359581100408143e-05 1.407612233553433e-05 diff --git a/panther_protein_class/metrics.json b/panther_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..447c20f198c56431ffbd9ea2804468898dc998ce --- /dev/null +++ b/panther_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2454, + "annotations_size": 150, + "title": "Average number of proteins per term", + "value": 11.546666666666667 +} \ No newline at end of file diff --git a/panther_protein_class/paths.json b/panther_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..ba3cdd9965500a6ba4a264781a6067dd4c76c510 --- /dev/null +++ b/panther_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/panther_protein_class/fragment/C340/C340_val_log2fc"} \ No newline at end of file diff --git a/panther_protein_class/result.tsv b/panther_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..e6d8ae9f05087d687cdfdaa64f2a5fa13f061f87 --- /dev/null +++ b/panther_protein_class/result.tsv @@ -0,0 +1,46 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +transporter 0.6173524480943031 3.334200619646625 0.0008554493350083 0.1204741434499083 0.1283174002512545 49 Q9Y619,P41440,O60830,O43772,Q99595,Q567V2,Q9NR77,Q9HD45,Q9H2D1,Q00169,O43681,P37198,Q9UI26 13 +oxidoreductase 0.634548353593025 2.8493346335171275 0.0043810774034169 0.482427344606738 0.1512228067943014 33 O75306,P13804,Q8N4Q0,Q16134,O43169,P00403,O95831,O43676,O14949 9 +serine protease 0.726994275046959 2.731206457029482 0.0063102927261837 0.6130822020799673 0.1512228067943014 17 P42785,Q9HB40,Q16740,Q9H3G5 4 +metalloprotease 0.6474452392604078 2.6030979290159806 0.0092385560548227 0.7514781297460197 0.1512228067943014 24 Q9NZ08,P31930,P55786,O43847,Q9UIQ6,O75844,P22695,Q5JRX3,Q99797 9 +oxygenase 0.939245497568613 2.408685718979054 0.0160100781987857 0.9111622501274328 0.17237947704924 6 P30519,P09601 2 +tubulin 0.9726530612244896 2.317108644920705 0.0204978142125638 0.9552481059457628 0.1921670082427856 4 Q9BUF5,P07437,P68371 3 +reductase 0.5699841201477567 2.2009018105879146 0.0277429757371721 0.9853052087307214 0.2311914644764342 27 Q06136,Q9H7Z7,Q9UDW1,P35270,P00374,Q14914,Q9UBM7,Q14739 8 +primary active transporter 0.5969884507538226 2.0954596938750414 0.0361301478485289 0.9959935521138076 0.245890431640409 20 Q8N4H5,Q9H2J7,O60888,Q9NS69 4 +membrane trafficking regulatory protein 0.649946884548638 2.0875818210434884 0.0368355732554868 0.9964102424781602 0.245890431640409 14 Q14108,P24390,Q8WTV0 3 +galactosidase 0.9441272430668805 2.043336950956805 0.041019094135857 0.99813149608593 0.245890431640409 2 P16278 1 +secondary carrier transporter 0.7101692047668505 2.0135510425851684 0.0440566908823805 0.9988390308706002 0.245890431640409 10 Q6NT16,Q8TB61,Q02978,P55011,Q9UBX3 5 +calmodulin-related 0.6894008382340756 2.011617457584454 0.0442602776952736 0.998875536223901 0.245890431640409 11 P60903,Q02818,P80303,P30626,Q14257,O43852 6 +G-protein coupled receptor 0.9070146818923268 1.8874272356065016 0.0591028847453987 0.9998925217587122 0.2907524880148499 2 Q5VW38 1 +transmembrane signal receptor 0.8013291751673043 1.8524199176708136 0.0639655473632669 0.9999505945206254 0.2907524880148499 6 Q9UMX5,Q99720,Q8WUJ1 3 +mitochondrial carrier protein 0.7049108936281283 1.6416605119860153 0.1006603794995233 0.9999998773806504 0.4040034372697992 7 Q9BSK2,Q6NUK1,Q70HW3 3 +phospholipase 0.7973953036222259 1.618613488122101 0.1055304511573982 0.9999999456957254 0.4040034372697992 4 Q8NHP8 1 +oxidase 0.6277621445154942 1.6084610053922683 0.1077342499386131 0.999999962491179 0.4040034372697992 10 P20674,P14406,Q8NB78,Q6ZRP7 4 +voltage-gated ion channel 0.9009996596613834 1.576281992071584 0.1149608298491906 0.9999999889242326 0.410574392318538 3 P21796 1 +glycosidase 0.7639269826241477 1.4808753958828182 0.1386397805354602 0.999999999810451 0.4402255332156956 4 Q9BTY2 1 +protease 0.4320158523670004 1.4638882181833592 0.1432244930526969 0.9999999999148752 0.4402255332156956 40 P28070,P28072,P20618,P49721,P60900,Q99436 6 +viral or transposable element protein 0.863493745525513 1.430967108726784 0.1524396419561087 0.9999999999831888 0.4402255332156956 3 Q9NUD5 1 +protein modifying enzyme 0.4927466786748873 1.421712591989578 0.1551097031273793 0.9999999999895276 0.4402255332156956 20 O15460,P13674,P50897,O60725,Q92791 5 +G-protein 0.7416602054402819 1.3887796942888044 0.1648997517033712 0.999999999998177 0.4402255332156956 4 P18085,Q9NTK5 2 +esterase 0.6878768071208216 1.3718680211493592 0.170104527159298 0.9999999999992863 0.4402255332156956 6 Q969T7 1 +SNARE protein 0.684925140624491 1.359167335252477 0.1740935695251173 0.9999999999996536 0.4402255332156956 6 Q9UNK0,P51809,O95721 3 +ATP synthase 0.4868350188702513 1.323206053838695 0.1857668633364415 0.999999999999959 0.4402255332156956 18 P61421,O75947,O75964,P56134,P24539,Q96IX5,Q93050,Q9Y487,Q15904 9 +chaperone 0.3655084618395027 1.2305962125035927 0.2184739225141747 1.0 0.4891207220466599 55 Q99543,Q8IXB1,Q99471,Q9Y680,Q8WXX5,O75937,Q00688,P46379,Q08752,P07237,Q9Y2R0,P61758,Q9NWM8,Q15185,Q8N183,O95456 16 +mRNA polyadenylation factor 0.524833361267151 1.0831752006135564 0.2787306650784464 1.0 0.5646388557719496 10 Q9ULM6,Q9UIV1,Q96GM8 3 +ATP-binding cassette (ABC) transporter 0.5434789979193067 1.0772665338559069 0.2813612087502632 1.0 0.5646388557719496 8 Q8NC96,Q03519,P08183,O15439,Q9NVZ3 5 +kinase 0.505786413738724 1.0535247145402966 0.29210057331931 1.0 0.5690270908817728 11 P35790,P15531,Q9HA64,Q9NVE7 4 +heterotrimeric G-protein 0.6534693877550988 1.0237004283168036 0.3059767930259447 1.0 0.5751098859969331 4 P04899,P08754,Q14344 3 +small GTPase 0.5184824298109776 1.0010899384401732 0.3167833289277033 1.0 0.5751098859969331 9 P11233 1 +calcium-binding protein 0.5712647991307751 0.791453646671129 0.4286793152489159 1.0 0.6642099867803258 5 P20073,P04083,P50995 3 +transfer/carrier protein 0.4354924169928136 0.6283364782463436 0.5297835398997361 1.0 0.7493057708931236 10 P17900,P12235,Q9Y5M8,O14828 4 +transferase 0.3629616350710488 0.6277129091162864 0.5301920271745346 1.0 0.7493057708931236 24 O43505,Q9NRN7,P48651,O14880,Q8NFF5,Q9BXW7,P43490,P37268 8 +dehydrogenase 0.3050562025157768 0.5689614388110298 0.569382309203083 1.0 0.7649453880521447 57 P30837,Q3SXM5,O94788,O75874,Q8WWV3,P48735 6 +histone modifying enzyme 0.4352840817559134 0.55885767216021 0.5762588589992823 1.0 0.7649453880521447 8 Q03164,Q9NWY4 2 +protein-binding activity modulator 0.5108411669939181 0.4700050624128469 0.6383514007252631 1.0 0.8046446227629367 4 O14737 1 +exoribonuclease 0.4130389743715089 0.348895406943743 0.7271678335082061 1.0 0.8546949353749135 7 Q15024,Q9Y2L1 2 +peroxidase 0.4497959183673413 0.2755580446681797 0.7828875378779232 1.0 0.9012389711668908 4 P32119,P30041,P30048 3 +nucleic acid metabolism protein 0.3751011956885354 0.1277356270088509 0.8983581947521737 1.0 0.9557002071831636 5 Q8IWR0 1 +aspartic protease 0.4192495921696576 0.1153792094528915 0.9081445573507256 1.0 0.9593076310042876 2 Q8TCT9 1 +hydrolase 0.2908251613024228 0.101961221301809 0.9187874555335191 1.0 0.96376306524495 20 O60502,P07099 2 +actin and actin related protein 0.3288239375983738 0.0503814177488855 0.959818444067335 1.0 0.9877559705679666 6 P61163,O96019 2 +phosphatase modulator 0.3977968176254606 0.0483769721774726 0.9614158113528208 1.0 0.9877559705679666 3 Q5H9R7,P30153 2 diff --git a/panther_protein_class/selections.json b/panther_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..76a7bb15abccd744b22c0ecbd5a204a68aa5d553 --- /dev/null +++ b/panther_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthase", "ATP-binding cassette (ABC) transporter", "C2H2 zinc finger transcription factor", "DNA glycosylase", "DNA helicase", "DNA ligase", "DNA metabolism protein", "DNA methyltransferase", "DNA polymerase processivity factor", "DNA topoisomerase", "DNA-binding transcription factor", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "G-protein", "G-protein coupled receptor", "G-protein modulator", "GTPase-activating protein", "Hsp90 family chaperone", "P53-like transcription factor", "RNA helicase", "RNA metabolism protein", "RNA methyltransferase", "RNA processing factor", "RNA splicing factor", "SNARE protein", "acetyltransferase", "actin and actin related protein", "actin binding motor protein", "actin or actin-binding cytoskeletal protein", "acyltransferase", "aldolase", "amino acid kinase", "amino acid transporter", "aminoacyl-tRNA synthetase", "apolipoprotein", "aspartic protease", "basic helix-loop-helix transcription factor", "basic leucine zipper transcription factor", "cadherin", "calcium-binding protein", "calmodulin-related", "carbohydrate kinase", "centromere DNA-binding protein", "chaperone", "chaperonin", "chromatin/chromatin-binding, or -regulatory protein", "cyclase", "cysteine protease", "cytokine", "cytoskeletal protein", "damaged DNA-binding protein", "decarboxylase", "defense/immunity protein", "dehydratase", "dehydrogenase", "endodeoxyribonuclease", "endoribonuclease", "epimerase/racemase", "esterase", "exodeoxyribonuclease", "exoribonuclease", "extracellular matrix glycoprotein", "extracellular matrix protein", "galactosidase", "general transcription factor", "glucosidase", "glycosidase", "glycosyltransferase", "guanyl-nucleotide exchange factor", "heterotrimeric G-protein", "histone", "histone modifying enzyme", "homeodomain transcription factor", "hydratase", "hydrolase", "integrin", "intermediate filament binding protein", "ion channel", "isomerase", "kinase", "kinase activator", "kinase inhibitor", "kinase modulator", "ligase", "lipase", "lyase", "mRNA capping factor", "mRNA polyadenylation factor", "major histocompatibility complex protein", "membrane traffic protein", "membrane trafficking regulatory protein", "metalloprotease", "methyltransferase", "microtubule binding motor protein", "microtubule or microtubule-binding cytoskeletal protein", "mitochondrial carrier protein", "mutase", "non-motor actin binding protein", "non-motor microtubule binding protein", "non-receptor serine/threonine protein kinase", "nucleic acid metabolism protein", "nucleotide kinase", "nucleotide phosphatase", "nucleotidyltransferase", "oxidase", "oxidoreductase", "oxygenase", "peptide hormone", "peroxidase", "phosphatase", "phosphatase activator", "phosphatase modulator", "phosphodiesterase", "phospholipase", "primary active transporter", "primase", "protease", "protease inhibitor", "protein modifying enzyme", "protein phosphatase", "protein-binding activity modulator", "pyrophosphatase", "reductase", "ribosomal protein", "scaffold/adaptor protein", "secondary carrier transporter", "serine protease", "small GTPase", "structural protein", "tight junction", "transaminase", "transcription cofactor", "transfer/carrier protein", "transferase", "transketolase", "translation elongation factor", "translation factor", "translation initiation factor", "translation release factor", "translational protein", "transmembrane signal receptor", "transporter", "tubulin", "tyrosine protein kinase receptor", "ubiquitin-protein ligase", "vesicle coat protein", "viral or transposable element protein", "voltage-gated ion channel", "winged helix/forkhead transcription factor", "zinc finger transcription factor"], "available_proteins": ["AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCF1", "ABCF2", "ABHD10", "ABHD12", "ABHD6", "ACAA2", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR6", "ADAM17", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGPAT1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK6", "AKAP1", "AKAP12", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "ALYREF", "ANAPC1", "ANAPC7", "ANKHD1", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APLP2", "APOL2", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARG2", "ARHGDIA", "ARIH1", "ARIH2", "ARL1", "ARL6IP5", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD5", "ATG4B", "ATL2", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1H", "ATPIF1", "ATXN2L", "AUP1", "B4GAT1", "BAG6", "BAIAP2", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCLAF1", "BLM", "BLMH", "BLVRA", "BOP1", "BRCA1", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BZW1", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBR1", "CCAR1", "CCAR2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD3EAP", "CDC23", "CDC27", "CDC37", "CDC42", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CEBPZ", "CENPB", "CEP170", "CFL1", "CFL2", "CHAF1B", "CHERP", "CHKA", "CHMP3", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT3", "CNOT6", "CNOT7", "CNP", "COA3", "COIL", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1B", "CORO1C", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX7A2", "COX7C", "CPD", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSE1L", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DCAF13", "DCAKD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDOST", "DEK", "DENR", "DERL1", "DGCR8", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DPF2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "ECE1", "ECH1", "ECHS1", "ECI2", "ECSIT", "EDC4", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF2", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOB", "ELP1", "EMC2", "EMG1", "ENAH", "ENO1", "ENY2", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERH", "ERO1A", "ERP29", "ESD", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC3", "EXOC5", "EXOC7", "EXOSC1", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "FAHD1", "FAM98A", "FARSA", "FARSB", "FBL", "FDFT1", "FDPS", "FECH", "FEN1", "FH", "FKBP14", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATB", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDI1", "GDI2", "GFPT1", "GGH", "GINS1", "GLA", "GLB1", "GLDC", "GLE1", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOT1", "GOT2", "GPATCH4", "GPD2", "GPI", "GPR107", "GPR108", "GPRASP2", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HADHB", "HAT1", "HBS1L", "HCCS", "HDGF", "HDGFL2", "HDHD5", "HDLBP", "HEATR1", "HECTD1", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIC2", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HM13", "HMGA1", "HMGCL", "HMOX1", "HMOX2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HOXA10", "HP1BP3", "HPF1", "HPRT1", "HSD17B10", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HTRA2", "HUWE1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IGBP1", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMPDH2", "INTS11", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "ISOC1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "KARS", "KCTD12", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0368", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KLC2", "KLC4", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRR1", "KYAT3", "L2HGDH", "LAMP1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LBR", "LDAH", "LDHA", "LDHB", "LETM1", "LGMN", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LRPAP1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSS", "LTN1", "LYAR", "LYPLA1", "MACF1", "MAGED2", "MAGT1", "MAP1B", "MAP1S", "MAP2K1", "MAPRE1", "MAPRE2", "MARK2", "MARS", "MAT2A", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "METAP2", "METTL13", "MGEA5", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINPP1", "MIPEP", "MMAB", "MMS19", "MOB4", "MOGS", "MORF4L1", "MPHOSPH10", "MPI", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MYBBP1A", "MYEF2", "MYG1", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAA15", "NAA25", "NAA35", "NAA50", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCBP1", "NCOA5", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA9", "NDUFAF2", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEDD4L", "NENF", "NEU1", "NHP2", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLN", "NME1", "NMT1", "NNT", "NOC4L", "NOL6", "NOL9", "NOM1", "NONO", "NOP56", "NOP58", "NPEPPS", "NPM1", "NPTN", "NRBP1", "NRDC", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUMA1", "NUP107", "NUP153", "NUP155", "NUP160", "NUP210", "NUP214", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCIAD1", "OCLN", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OTUB1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPN1", "PACSIN2", "PAFAH1B3", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PARG", "PARN", "PARP1", "PARP2", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCMT1", "PCNA", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PEBP1", "PECR", "PEPD", "PES1", "PEX14", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHC2", "PHF6", "PHGDH", "PI4KB", "PICALM", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLAA", "PLBD2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLD1", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1R10", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PPP6R3", "PPT1", "PQBP1", "PRAF2", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTCD1", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PUF60", "PURA", "PUS1", "PWP1", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB3GAP1", "RAB3GAP2", "RABGAP1", "RABGGTA", "RABL6", "RAC1", "RAD23B", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM34", "RBM4", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDX", "RECQL", "RECQL5", "REEP5", "REPS1", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIF1", "RIOK2", "RIPK1", "RNASEH2A", "RNPS1", "ROCK2", "RP2", "RPA1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP7A", "RRS1", "RSF1", "RSL1D1", "RTN4IP1", "S100A10", "S100A11", "SACM1L", "SAE1", "SAMHD1", "SAP18", "SAP30BP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF8", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCO1", "SCP2", "SCPEP1", "SCRIB", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35B2", "SLC6A15", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC6", "SMN1*", "SMNDC1", "SMPD4", "SMYD3", "SNAP29", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPCS2", "SPCS3", "SPEN", "SPR", "SPTLC1", "SQLE", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSU72", "STAG2", "STAT3", "STOML2", "STRAP", "STRBP", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUPT16H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYNCRIP", "SYNGR2", "TAF15", "TAGLN2", "TALDO1", "TAP1", "TAP2", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCE", "TBL3", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDRKH", "TECR", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TJP1", "TJP2", "TK1", "TKT", "TM9SF3", "TMED10", "TMED7", "TMED9", "TMOD3", "TMPO", "TMX2", "TNPO1", "TOE1", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TP53", "TP53BP1", "TPI1", "TPM3", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRAP1", "TRIM26", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRMT6", "TRMU", "TRNT1", "TROVE2", "TSC2", "TSFM", "TSG101", "TSTA3", "TTK", "TTYH3", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "UBE3C", "UBE4A", "UBR4", "UBR5", "UBR7", "UBTF", "UCHL5", "UFL1", "UGDH", "UGGT1", "UHRF1", "UMPS", "UNC119B", "UNG", "UQCR10", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USMG5", "USO1", "USP10", "USP14", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP6", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VBP1", "VDAC1", "VDAC2", "VDAC3", "VPS13A", "VPS16", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4B", "VPS53", "VRK1", 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sha256:31df5152caee80114429c573a658936c775490146266609a17e101fdb8bd775c +size 135766 diff --git a/pharos_dto/basic/plot_8.png b/pharos_dto/basic/plot_8.png new file mode 100644 index 0000000000000000000000000000000000000000..0be4f3aaf389eb6ea347f7d94143a1a56c716aa6 --- /dev/null +++ b/pharos_dto/basic/plot_8.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:09e4df26067485eb385d5add2fb6d915b9c63c3e8d636715ec867b3851eb15e1 +size 130334 diff --git a/pharos_dto/basic/plot_9.png b/pharos_dto/basic/plot_9.png new file mode 100644 index 0000000000000000000000000000000000000000..eeb077ea317656edb71574154918edd78e321c38 --- /dev/null +++ b/pharos_dto/basic/plot_9.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:98dea37ca62468b205bd20384991ac069b4c35abd0ccff4e81faa2af3be5a774 +size 135950 diff --git a/pharos_dto/consensus.joblib b/pharos_dto/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..07bfd046916d2f9c538b057fa654e624a9ae0164 --- /dev/null +++ b/pharos_dto/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:66f679837309f8018ed1ef3189c81f47423de73c5c5128c7563a88f050a04fb9 +size 317929 diff --git a/pharos_dto/df_merge.tsv b/pharos_dto/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..7deddcf8c3399c66273b57be77affaf177140f1b --- /dev/null +++ b/pharos_dto/df_merge.tsv @@ -0,0 +1,10 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +SLC superfamily of solute carriers 17 32 3.0787866383834777 0.0020784547759924 18.888349514563107 44.33009708737864 2.1618907004737498 0.1690913715307362 9.633686860107934 5.825351940723624 1.7350998035598977 0.2760301582542676 1.0 0.0566899593979067 0.0319499068250687 0.0322368813739424 0.0066004680757576 +SLC25 family of mitochondrial transporters 11 18 2.7586513649843054 0.0058040418852931 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 1.0 0.0135379522122687 0.0054315442599267 0.001820540651884 7.737005366043537e-07 +Reductase 5 15 2.751288211392267 0.0059361390653125 4.563106796116505 16.313106796116504 1.2016212969729014 0.3130807121312539 1.9089462498224232 1.180966799206311 0.8349037556988175 0.2876306629725971 1.0 0.1305522111527444 0.0027014769688677 5.5308739194744206e-05 0.0022049588120054 +Oxidoreductase 19 97 2.700093287043322 0.0069320035745259 26.983009708737864 113.91747572815534 0.6392672411957 0.4324241122550336 10.483097938966514 7.235161275092307 1.3581321831066435 0.3819609334162012 1.0 0.0182713904115901 0.0002028181450683 1.696814608748335e-07 2.6663978242041004e-05 +Receptor 7 20 2.6958100826443783 0.0070217688757439 8.25242718446602 27.344660194174757 1.739519175745715 0.1905542238199536 2.855648283399814 4.245230977176689 1.1861053756197322 0.2707159726336181 1.0 0.0142331659478869 0.003645938876645 0.0140990291270638 0.137145509827698 +Mitochondrial nucleotide transporter subfamily 6 9 2.2083755961594664 0.0272181015210388 4.216019417475728 9.065533980582524 1.5870110662923598 0.1668197633609344 2.720728714423222 1.1029864386277723 1.1616247375257451 0.2431804664231326 1.0 0.0697581245313758 0.0090253131212995 0.0050923434600555 2.6076404564241632e-06 +Calcium-binding protein 7 15 2.138071162043319 0.0325109680503812 6.135922330097087 18.021844660194176 1.3650952896045327 0.2072953623045914 2.3371152398743247 2.2037057261181348 1.237653756718734 0.2545563939054063 1.0 0.0204708743585679 0.0099655953739765 0.0007742112182462 0.0002849290507727 +Transporter 46 146 2.1272235325714752 0.0334015147497028 57.59466019417476 188.27912621359224 1.4971900036635353 0.4160578104205245 21.77919356765414 18.57070590158326 1.926868489654782 0.421013047757716 1.0 0.2061592057158703 0.0471239735997421 0.0072763089095335 0.0003242502595095 +Metalloprotease 9 34 2.042766370482212 0.0410755711013899 10.080097087378642 37.81310679611651 1.0846602244748076 0.3802793741361127 4.2814674000125414 2.184793664748831 0.9789887795730944 0.3416347995760264 1.0 0.297366720714231 0.0006947605035307 0.0003558175935407 0.002441731581876 diff --git a/pharos_dto/metrics.json b/pharos_dto/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..e5963b61915db63ba10f8afd6a1d70526965f7c0 --- /dev/null +++ b/pharos_dto/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2454, + "annotations_size": 1638, + "title": "Average number of proteins per term", + "value": 3.1086691086691087 +} \ No newline at end of file diff --git a/pharos_dto/paths.json b/pharos_dto/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..fce298e6e537d436215d2fb804fcb1f3040131ea --- /dev/null +++ b/pharos_dto/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_dto/fragment/C340/C340_val_log2fc"} \ No newline at end of file diff --git a/pharos_dto/result.tsv b/pharos_dto/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..a4b593c490306e59ebf2a4d69276b956c3b179ea --- /dev/null +++ b/pharos_dto/result.tsv @@ -0,0 +1,60 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +SLC superfamily of solute carriers 0.6747862225925756 3.0787866383834777 0.0020784547759924 0.9668943690624896 0.0458124223460756 32 Q9Y619,Q8IXU6,P41440,O43772,Q8TB61,Q6NT16,Q9BSK2,Q9H2J7,Q9HC21,Q6NUK1,Q02978,O43808,Q9H2D1,P55011,P12235,Q9UBX3,Q70HW3 17 +SLC25 family of mitochondrial transporters 0.7241678660715116 2.7586513649843054 0.0058040418852931 0.9999277022393216 0.046150585476263 18 Q9Y619,O43772,Q9BSK2,Q9HC21,Q02978,Q6NUK1,O43808,Q9H2D1,P12235,Q9UBX3,Q70HW3 11 +Reductase 0.7612150168088695 2.751288211392267 0.0059361390653125 0.9999418433441112 0.0466235504449406 15 Q9UDW1,Q9H7Z7,P00374,Q9UBM7,Q14739 5 +Oxidoreductase 0.4616517136062469 2.700093287043322 0.0069320035745259 0.9999887389401996 0.0469135031277084 97 Q9H7Z7,P14406,Q15392,Q14739,O75306,Q8N4Q0,Q16134,Q16850,P13804,P30837,O43169,P00374,P00403,P20674,O95831,Q9UBM7,Q9UDW1,O94788,Q14914 19 +Receptor 0.6969266920507501 2.6958100826443783 0.0070217688757439 0.9999902887780616 0.0469135031277084 20 Q14108,Q9BUN8,Q9UQB8,Q567V2,Q8WTV0,Q9NR77,A6NIH7 7 +Tubulin 0.9726530612244896 2.317108644920705 0.0204978142125638 0.999999999999998 0.0734691896721652 4 Q9BUF5,P07437,P68371 3 +Mitochondrial nucleotide transporter subfamily 0.7667439112354153 2.2083755961594664 0.0272181015210388 1.0 0.0865694180416731 9 Q9BSK2,Q9HC21,Q6NUK1,O43808,Q9H2D1,Q70HW3 6 +Calcium-binding protein 0.6475020612012745 2.138071162043319 0.0325109680503812 1.0 0.0977118636083017 15 P60903,Q02818,P80303,P60660,Q14257,P43307,O43852 7 +Transporter 0.4264920737470181 2.1272235325714752 0.0334015147497028 1.0 0.0985796056937176 146 Q9Y619,Q9UJS0,Q9Y3B3,Q8TB61,Q99523,O95721,P08183,Q6NUK1,P61923,O60645,Q9HD45,Q9BQE5,O15439,O43808,P37198,P61421,Q8IXU6,O43772,Q9BSK2,O75947,Q8NFH4,Q02978,Q9H2D1,Q6NT16,P41440,P56134,Q9H2J7,Q9HC21,Q15388,Q93050,P55011,P24390,P12235,O43760,Q70HW3,P17900,P11279,Q9UNZ2,Q92973,Q8WUX9,P51809,Q92572,P24539,Q9Y487,Q9UBX3,Q00169 46 +Metalloprotease 0.5184844803916879 2.042766370482212 0.0410755711013899 1.0 0.1111513082658839 34 Q9NZ08,P31930,P55786,O43847,Q9UIQ6,O75844,P22695,Q5JRX3,Q99797 9 +Intracellular calcium-sensing protein 0.6282609857297692 1.910582945299961 0.0560581977799656 1.0 0.1350343058287996 13 P60903,Q02818,P80303,P60660,Q14257,O43852 6 +Calmodulin 0.6282609857297692 1.910582945299961 0.0560581977799656 1.0 0.1350343058287996 13 P60903,Q02818,P80303,P60660,Q14257,O43852 6 +SLC35 family of nucleotide sugar transporters 0.8943719412724234 1.833953901114555 0.0666608373933939 1.0 0.1485584376195635 2 Q8IXU6 1 +Oxidase 0.6039094273692311 1.8309600832953372 0.0671065012255651 1.0 0.1487793435534678 14 P13804,O43169,P14406,P20674,Q15067 5 +Signaling 0.5981749857240798 1.798478150778965 0.072101268038444 1.0 0.1553972066407518 14 Q8WUJ1 1 +Mitochondrial amino acid transporter subfamily 0.833643873462099 1.7665164651355747 0.0773092417169167 1.0 0.1619341917292962 4 O43772 1 +Mitochondrial di- and tri-carboxylic acid transporter subfamily 0.876427406199022 1.7577777131789762 0.0787853388710233 1.0 0.1637695242014419 2 Q9UBX3 1 +Protease 0.3803758768923615 1.744689915684779 0.0810388596164215 1.0 0.1667608694116815 98 Q9NZ08,Q9HB40,P55786,P42785,Q9UIQ6,O43847,O75844,P10619,Q8NHP8,Q5BJF2,Q13510,Q9H3G5 12 +Exoribonuclease 0.6987983993296546 1.4188008342681688 0.1559570894069604 1.0 0.2606026215455387 6 Q15024,Q9Y3B2,Q9Y2L1,Q9NQT5 4 +Chromodomain 0.8494492044063684 1.37645728993164 0.1686801015807824 1.0 0.2746501057547927 3 Q13185,P83916 2 +SNARE protein 0.684925140624491 1.359167335252477 0.1740935695251173 1.0 0.2801262944359933 6 Q9UNK0,P51809,O95721 3 +Damaged DNA-binding protein 0.7573409461663816 1.247857056115424 0.2120834096046167 1.0 0.3178340575776415 2 Q9NYH9 1 +Esterase 0.5553701435917352 1.18632546456514 0.235493794085229 1.0 0.3386644729689247 9 P50897 1 +Extracellular structure 0.5865346183676365 1.1022113068100994 0.2703698175192608 1.0 0.3722227553519279 7 O75718,Q92791,O43290 3 +Heterotrimeric G-protein 0.6534693877550988 1.0237004283168036 0.3059767930259447 1.0 0.4051657129963601 4 P04899,P08754,Q14344 3 +V-type ATPase 0.5587051858799286 0.9745967634180208 0.3297603197254957 1.0 0.4269939950279541 7 Q93050,Q9Y487 2 +Methyl-lysine/arginine binding protein 0.614762896576444 0.9725217562583036 0.3307910467743742 1.0 0.4274718207129738 5 Q13185,P83916 2 +Glycosidase 0.7330565229398365 0.92866512400627 0.3530626603236344 1.0 0.4457851310815146 3 Q86W56 1 +Serine protease 0.3974869719827796 0.9121781570920626 0.3616749404209174 1.0 0.4536168088893282 25 P42785,Q9HB40,Q9H3G5 3 +Phosphatase 0.4161742283722679 0.902460431729485 0.3668123314857956 1.0 0.4572592077425671 20 Q8IWA4,Q9Y217,P11117,Q14738,O43681 5 +ATP-binding cassette transporter family 0.5640427011505411 0.8392374562165842 0.4013360722994201 1.0 0.4860753172006842 6 P08183 1 +Microtubule family cytoskeletal protein 0.3740147132028357 0.8102741978238586 0.4177826013920751 1.0 0.4984179905901085 31 Q9BUF5,Q9BVA1,P07437,Q15555,P13693,P68371 6 +CDK1 subfamily 0.6447797716150123 0.7783007707902051 0.4363917212099475 1.0 0.5130570317797206 2 P24941 1 +Nucleotide phosphatase 0.4775175806224575 0.7567599318234435 0.4491937019373937 1.0 0.5214594498748766 8 Q8IWA4,O43681 2 +Nucleotide kinase 0.68512707913041 0.7512756155241732 0.4524868011850225 1.0 0.523427528489454 3 P23919 1 +Phosphatase inhibitor 0.5491225218342446 0.7014437326743261 0.4830261377887197 1.0 0.5449013868442996 5 Q01105,P55209 2 +F-type and V-type ATPases 0.4083356418136116 0.680883157695099 0.4959454259347606 1.0 0.5552690414771961 14 P61421,O75947,P56134,P24539,Q93050,Q9Y487 6 +Phosphatase modulator 0.4917639236717345 0.6733068381336603 0.5007521033040485 1.0 0.5579809151102255 7 Q01105,P55209 2 +Adenylate kinase family 0.6170473083197326 0.6696856974244738 0.5030581710920363 1.0 0.5588541638992358 2 P54819 1 +Translation initiation factor 0.372442001445276 0.605859522209787 0.5446080403870162 1.0 0.5923426096639658 20 P60228,Q15056,P63241,O75153,Q9Y262,Q9UJA5,O75822,P55010,P56537 9 +Eraser 0.4853980939731672 0.5180441331954021 0.6044274775607217 1.0 0.6342422858708918 6 Q8NB78 1 +G-protein 0.3382089106823372 0.4733613253408937 0.6359554169804413 1.0 0.658051151619686 25 Q9NTK5,P11233,Q9UI26 3 +Unclassified protein 0.3693008211790085 0.4570124613790022 0.6476620886810109 1.0 0.6693189282394296 14 P15531,Q9HA64,Q9NVE7 3 +F-type ATPase 0.4368932762605671 0.4417048185573689 0.658702822372462 1.0 0.6798709660025789 7 P06576,O75947,P56134,P24539,P36542 5 +Translation factor 0.3242209016559795 0.3736565480838437 0.7086598569532612 1.0 0.7277647935357002 25 P60228,Q15056,P24534,P23588,P63241,O75153,Q9Y262,Q9UJA5,O75822,P55010,P56537 11 +Membrane trafficking regulatory protein 0.3327700238692704 0.2948850171901983 0.768081717841772 1.0 0.7868154182769372 16 P11279,Q96AX1,Q9UNZ2,P24390,O43760 5 +Small GTPase 0.3221855345800603 0.2821256282039455 0.7778471826210618 1.0 0.7958236634186754 20 P11233 1 +Peroxidase 0.4497959183673413 0.2755580446681797 0.7828875378779232 1.0 0.8004805162572024 4 P32119,P30041,P30048 3 +mRNA splicing factor 0.2777091554938664 0.2367082312116469 0.8128831488368724 1.0 0.8280488792256201 52 Q13242,Q14011,Q8WXF1,Q92804,Q01844,Q8IY67,Q9BWF3,P33240,P62312,P62995,P84103,P38159,P23246,Q07955,Q15428,P35637,O75934,O75494,Q96PK6 19 +Nuclease 0.2973241320807914 0.2064337610848913 0.8364521011874653 1.0 0.8499432641098438 30 Q15024,Q9H7B2,Q9Y2L1,Q5JSZ5,Q9NQT5,Q9UHB6,Q9ULM6,Q9Y3B2,Q9UQ84 9 +Hydrolase 0.2707138114481071 0.1923872639017251 0.8474388679931284 1.0 0.8600401894502753 77 Q8IWA4,Q969T7,P11117,Q14738,P50897,P16278,P10253,O43681,Q99519 9 +TK group 0.457772337821298 0.1200696217327232 0.9044279966079762 1.0 0.916173814745742 3 Q15375,P41240 2 +VRK family 0.4163947797716128 0.1112882335777128 0.9113877856896916 1.0 0.9226533949071164 2 Q8IV63 1 +CK1 group 0.4165646674826597 0.066286420610165 0.9471497942298204 1.0 0.9570828889256296 3 P48729,Q8IV63 2 +Dehydrogenase 0.2630996432379229 0.0527950412676274 0.957895212487609 1.0 0.9667482181483078 49 O75306,Q8N4Q0,O94788,Q14914,O95831 5 +Actin and actin related protein 0.3288239375983738 0.0503814177488855 0.959818444067335 1.0 0.96809274099895 6 P61163,O96019 2 +Growth factor 0.3240816326530566 0.0315384347396213 0.9748401408900228 1.0 0.981430947005444 4 O75475,P51858,Q7Z4V5 3 +Tight junction 0.3370053039575675 0.0134086723536376 0.9893017479266996 1.0 0.9947675034401068 3 Q16625,Q9UDY2 2 +Cell-cell junction 0.3370053039575675 0.0134086723536376 0.9893017479266996 1.0 0.9947675034401068 3 Q16625,Q9UDY2 2 diff --git a/pharos_dto/selections.json b/pharos_dto/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..cb27e17bb73e1045e0bd53added784776c4e8b82 --- /dev/null +++ b/pharos_dto/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase", "10 kDa heat shock protein, mitochondrial", "116 kDa U5 small nuclear ribonucleoprotein component", "14-3-3 protein beta/alpha", "14-3-3 protein epsilon", "14-3-3 protein eta", "14-3-3 protein gamma", "14-3-3 protein theta", "14-3-3 protein zeta/delta", "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "2',5'-phosphodiesterase 12", "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial", "26S proteasome non-ATPase regulatory subunit 1", "26S proteasome non-ATPase regulatory subunit 12", "26S proteasome non-ATPase regulatory subunit 13", "26S proteasome non-ATPase regulatory subunit 14", "26S proteasome non-ATPase regulatory subunit 2", "26S proteasome non-ATPase regulatory subunit 3", "26S proteasome non-ATPase regulatory subunit 4", "26S proteasome non-ATPase regulatory subunit 7", "26S proteasome non-ATPase regulatory subunit 8", "26S proteasome regulatory subunit 10B", "26S proteasome regulatory subunit 4", "26S proteasome regulatory subunit 6A", "26S proteasome regulatory subunit 6B", "26S proteasome regulatory subunit 7", "26S proteasome regulatory subunit 8", "28S ribosomal protein S11, mitochondrial", "28S ribosomal protein S2, mitochondrial", "28S ribosomal protein S27, mitochondrial", "28S ribosomal protein S29, mitochondrial", "28S ribosomal protein S35, mitochondrial", "28S ribosomal protein S5, mitochondrial", "28S ribosomal protein S7, mitochondrial", "3-hydroxyacyl-CoA dehydrogenase type-2", "3-hydroxyisobutyrate dehydrogenase, mitochondrial", "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial", "3-ketoacyl-CoA thiolase, mitochondrial", "3-mercaptopyruvate sulfurtransferase", "39S ribosomal protein L1, mitochondrial", "39S ribosomal protein L11, mitochondrial", "39S ribosomal protein L12, mitochondrial", "39S ribosomal protein L14, mitochondrial", "39S ribosomal protein L19, mitochondrial", "39S ribosomal protein L2, mitochondrial", "39S ribosomal protein L21, mitochondrial", "39S ribosomal protein L24, mitochondrial", "39S ribosomal protein L38, mitochondrial", "39S ribosomal protein L39, mitochondrial", "39S ribosomal protein L44, mitochondrial", "39S ribosomal protein L47, mitochondrial", "39S ribosomal protein L48, mitochondrial", "39S ribosomal protein L9, mitochondrial", "4-trimethylaminobutyraldehyde dehydrogenase", "40S ribosomal protein S10", "40S ribosomal protein S11", "40S ribosomal protein S12", "40S ribosomal protein S13", "40S ribosomal protein S14", "40S ribosomal protein S15", "40S ribosomal protein S15a", "40S ribosomal protein S17", "40S ribosomal protein S18", "40S ribosomal protein S19", "40S ribosomal protein S2", "40S ribosomal protein S20", "40S ribosomal protein S21", "40S ribosomal protein S23", "40S ribosomal protein S24", "40S ribosomal protein S28", "40S ribosomal protein S3", "40S ribosomal protein S3a", "40S ribosomal protein S4, X isoform", "40S ribosomal protein S5", "40S ribosomal protein S6", "40S ribosomal protein S7", "40S ribosomal protein S8", "40S ribosomal protein S9", "40S ribosomal protein SA", "45 kDa calcium-binding protein", "4F2 cell-surface antigen heavy chain", "5'-nucleotidase domain-containing protein 1", "5'-nucleotidase domain-containing protein 2", "6-phosphogluconate dehydrogenase, decarboxylating", "6-phosphogluconolactonase", "60 kDa SS-A/Ro ribonucleoprotein", "60S ribosomal protein L10", "60S ribosomal protein L10a", "60S ribosomal protein L11", "60S ribosomal protein L12", "60S ribosomal protein L13", "60S ribosomal protein L13a", "60S ribosomal protein L14", "60S ribosomal protein L15", "60S ribosomal protein L18", "60S ribosomal protein L19", "60S ribosomal protein L21", "60S ribosomal protein L22", "60S ribosomal protein L23", "60S ribosomal protein L23a", "60S ribosomal protein L24", "60S ribosomal protein L27", "60S ribosomal protein L27a", "60S ribosomal protein L28", "60S ribosomal protein L29", "60S ribosomal protein L3", "60S ribosomal protein L30", "60S ribosomal protein L31", "60S ribosomal protein L32", "60S ribosomal protein L35", "60S ribosomal protein L35a", "60S ribosomal protein L36", "60S ribosomal protein L36a", "60S ribosomal protein L37", "60S ribosomal protein L38", "60S ribosomal protein L5", "60S ribosomal protein L6", "60S ribosomal protein L7", "60S ribosomal protein L7-like 1", "60S ribosomal protein L7a", "60S ribosomal protein L8", "60S ribosomal protein L9", "7,8-dihydro-8-oxoguanine triphosphatase", "7-dehydrocholesterol reductase", "7-methylguanosine phosphate-specific 5'-nucleotidase", "A-kinase anchor protein 1, mitochondrial", "ABCB subfamily", "ABCC subfamily", "ABCD subfamily of peroxisomal ABC transporters", "ADP-dependent glucokinase", "ADP-ribose pyrophosphatase, mitochondrial", "ADP-sugar pyrophosphatase", "ADP/ATP translocase 1", "ADP/ATP translocase 2", "ADP/ATP translocase 3", "AFG3-like protein 2", "AGC group", "AH receptor-interacting protein", "AK1 subfamily", "AK2 subfamily", "AKT family", "AP-1 complex subunit beta-1", "AP-1 complex subunit gamma-1", "AP-1 complex subunit mu-1", "AP-2 complex subunit alpha-1", "AP-2 complex subunit alpha-2", "AP-2 complex subunit beta", "AP-2 complex subunit mu", "AP-3 complex subunit beta-1", "AP-3 complex subunit delta-1", "AP-3 complex subunit mu-1", "AP-3 complex subunit sigma-1", "ATP synthase F(0) complex subunit B1, mitochondrial", "ATP synthase subunit alpha, mitochondrial", "ATP synthase subunit beta, mitochondrial", "ATP synthase subunit d, mitochondrial", "ATP synthase subunit e, mitochondrial", "ATP synthase subunit f, mitochondrial", "ATP synthase subunit gamma, mitochondrial", "ATP-binding cassette sub-family B member 7, mitochondrial", "ATP-binding cassette sub-family D member 3", "ATP-binding cassette sub-family F member 1", "ATP-binding cassette sub-family F member 2", "ATP-binding cassette transporter family", "ATP-citrate synthase", "ATP-dependent 6-phosphofructokinase, muscle type", "ATP-dependent 6-phosphofructokinase, platelet type", "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial", "ATP-dependent DNA helicase Q1", "ATP-dependent DNA helicase Q5", "ATP-dependent PFK group I subfamily", "ATP-dependent RNA helicase A", "ATP-dependent RNA helicase DHX29", "ATP-dependent RNA helicase DHX8", "ATP-dependent zinc metalloprotease YME1L1", "ATPase ASNA1", "ATPase family AAA domain-containing protein 3A", "ATPase family AAA domain-containing protein 3B", "ATPase inhibitor, mitochondrial", "Acetolactate synthase-like protein", "Acetyl-CoA acetyltransferase, cytosolic", "Acetyl-CoA acetyltransferase, mitochondrial", "Acetyl-coenzyme A transporter 1", "Acetyltransferase", "Acid ceramidase", "Acidic leucine-rich nuclear phosphoprotein 32 family member B", "Acidic leucine-rich nuclear phosphoprotein 32 family member E", "Aconitate hydratase, mitochondrial", "Actin and actin related protein", "Actin binding motor protein", "Actin family cytoskeletal protein", "Actin-like protein 6A", "Actin-related protein 2", "Actin-related protein 2/3 complex subunit 1A", "Actin-related protein 2/3 complex subunit 1B", "Actin-related protein 2/3 complex subunit 3", "Actin-related protein 2/3 complex subunit 4", "Actin-related protein 3", "Actin-related protein 6", "Acyl-CoA dehydrogenase family member 9, mitochondrial", "Acyl-CoA synthetase family member 3, mitochondrial", "Acyl-coenzyme A thioesterase 9, mitochondrial", "Acylamino-acid-releasing enzyme", "Acylpyruvase FAHD1, mitochondrial", "Acyltransferase", "Adenosine 3'-phospho 5'-phosphosulfate transporter 1", "Adenosine kinase", "Adenosylhomocysteinase", "Adenylate kinase 2, mitochondrial", "Adenylate kinase family", "Adenylate kinase isoenzyme 1", "Adenylate kinase isoenzyme 6", "Adenylosuccinate lyase", "Adenylosuccinate synthetase isozyme 2", "Adenylyl cyclase-associated protein 1", "Afadin", "Aflatoxin B1 aldehyde reductase member 2", "Alanine--tRNA ligase, cytoplasmic", "Alanine--tRNA ligase, mitochondrial", "Alanine/serine/cysteine transporter subfamily", "Alanyl-tRNA editing protein Aarsd1", "Alcohol dehydrogenase [NADP(+)]", "Alcohol dehydrogenase class-3", "Aldehyde dehydrogenase X, mitochondrial", "Aldehyde dehydrogenase, mitochondrial", "Aldose reductase", "Alpha-adducin", "Alpha-aminoadipic semialdehyde dehydrogenase", "Alpha-centractin", "Alpha-enolase", "Alpha-soluble NSF attachment protein", "Alpha-taxilin", "Amidophosphoribosyltransferase", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1", "Aminoacyl-tRNA synthetase", "Amyloid-beta A4 protein", "Amyloid-like protein 2", "Anaphase-promoting complex subunit 1", "Ancient ubiquitous protein 1", "Anion channel tweety (tweety) family", "Antibacterial response protein", "Antigen peptide transporter 1", "Antigen peptide transporter 2", "Apolipoprotein", "Apolipoprotein L2", "Apoptosis-inducing factor 1, mitochondrial", "Arginase-2, mitochondrial", "Asparagine synthetase [glutamine-hydrolyzing]", "Asparagine--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, mitochondrial", "Aspartic protease", "Ataxin-2-like protein", "Atlastin-2", "Atp-dependent 6-phosphofructokinase, liver type", "Atypical group", "B-cell receptor-associated protein 31", "BTB/POZ domain-containing protein KCTD12", "BUB family", "Basic leucine zipper and W2 domain-containing protein 1", "Bcl-2-associated transcription factor 1", "Beta-centractin", "Beta-galactosidase", "Beta-hexosaminidase subunit alpha", "Beta-hexosaminidase subunit beta", "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1", "Bifunctional glutamate/proline--tRNA ligase", "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial", "Bifunctional purine biosynthesis protein PURH", "Biliverdin reductase A", "Biotin--protein ligase", "Bleomycin hydrolase", "Brain-specific angiogenesis inhibitor 1-associated protein 2", "Branched-chain-amino-acid aminotransferase, mitochondrial", "Breast cancer type 1 susceptibility protein", "Bromodomain", "Bromodomain-containing protein 2", "C-1-tetrahydrofolate synthase, cytoplasmic", "C-Jun-amino-terminal kinase-interacting protein 4", "C-terminal-binding protein 1", "C-terminal-binding protein 2", "C2H2 zinc finger transcription factor", "CAAX prenyl protease 1 homolog", "CAD protein", "CAMK group", "CAMK2 family", "CAMKL family", "CCAAT/enhancer-binding protein zeta", "CCK4 family", "CCR4-NOT transcription complex subunit 1", "CCR4-NOT transcription complex subunit 3", "CCR4-NOT transcription complex subunit 6", "CCR4-NOT transcription complex subunit 7", "CDK family", "CDK1 subfamily", "CDK4 subfamily", "CDK5 subfamily", "CK1 family", "CK1 group", "CK2 family", "CLIP-associating protein 1", "CLIP-associating protein 2", "CMGC group", "COP9 signalosome complex subunit 3", "COP9 signalosome complex subunit 5", "COP9 signalosome complex subunit 6", "COP9 signalosome complex subunit 8", "CSK family", "CTP synthase 1", "CTP synthase 2", "Ca2+-ATPases", "Cadherin", "Calcium homeostasis endoplasmic reticulum protein", "Calcium uptake protein 1, mitochondrial", "Calcium uptake protein 2, mitochondrial", "Calcium-binding mitochondrial carrier protein Aralar1", "Calcium-binding mitochondrial carrier protein Aralar2", "Calcium-binding mitochondrial carrier protein SCaMC-1", "Calcium-binding protein", "Calcium/calmodulin-dependent protein kinase type ii subunit delta", "Calcium/calmodulin-dependent protein kinase type ii subunit gamma", "Calcyclin-binding protein", "Calmegin", "Calmodulin", "Calnexin", "Calpain-1 catalytic subunit", "Calpain-2 catalytic subunit", "Calponin-2", "Calponin-3", "Calreticulin", "Calumenin", "Camp-dependent protein kinase catalytic subunit alpha", "Cancer-related nucleoside-triphosphatase", "Caprin-1", "Carbohydrate kinase", "Carbohydrate sulfotransferase 14", "Carnitine O-palmitoyltransferase 2, mitochondrial", "Cartilage-associated protein", "Casein kinase i isoform alpha", "Casein kinase ii subunit beta", "Cat eye syndrome critical region protein 2", "Catechol O-methyltransferase", "Catenin alpha-1", "Catenin delta-1", "Cation-independent mannose-6-phosphate receptor", "Cell adhesion", "Cell cycle and apoptosis regulator protein 2", "Cell division control protein 42 homolog", "Cell division cycle and apoptosis regulator protein 1", "Cell-cell junction", "Cellular structure", "Cellular tumor antigen p53", "Centromere/kinetochore protein zw10 homolog", "Centrosomal protein of 170 kDa", "Chaperone", "Chaperonin", "Charged multivesicular body protein 3", "Charged multivesicular body protein 7", "Chloride channel family", "Chloride intracellular channel protein 1", "Choline kinase alpha", "Choline/ethanolamine kinase family", "Chromatin accessibility complex protein 1", "Chromatin assembly factor 1 subunit B", "Chromatin/chromatin-binding protein", "Chromobox protein homolog 1", "Chromobox protein homolog 3", "Chromobox protein homolog 5", "Chromodomain", "Chromosome-associated kinesin KIF4A", "Cilia- and flagella-associated protein 20", "Citrate synthase, mitochondrial", "ClC-3/CLCN3 subfamily", "Clathrin heavy chain 1", "Cleavage and polyadenylation specificity factor subunit 1", "Cleavage and polyadenylation specificity factor subunit 3", "Cleavage and polyadenylation specificity factor subunit 5", "Cleavage and polyadenylation specificity factor subunit 6", "Cleavage and polyadenylation specificity factor subunit 7", "Cleavage stimulation factor subunit 2", "Cleavage stimulation factor subunit 3", "Cleft lip and palate transmembrane protein 1", "Clustered mitochondria protein homolog", "Coactosin-like protein", "Coatomer subunit alpha", "Coatomer subunit beta", "Coatomer subunit beta'", "Coatomer subunit delta", "Coatomer subunit gamma-1", "Coatomer subunit gamma-2", "Coatomer subunit zeta-1", "Cohesin subunit SA-2", "Coilin", "Cold-inducible RNA-binding protein", "Condensin complex subunit 1", "Core histone macro-H2A.1", "Core histone macro-H2A.2", "Coronin-1B", "Coronin-1C", "Creatine kinase B-type", "Creatine kinase U-type, mitochondrial", "Crooked neck-like protein 1", "Cullin-1", "Cullin-2", "Cullin-4A", "Cullin-4B", "Cullin-5", "Cullin-associated NEDD8-dissociated protein 1", "Cyclase", "Cyclin-dependent kinase 1", "Cyclin-dependent kinase 12", "Cyclin-dependent kinase 2", "Cyclin-dependent kinase 4", "Cyclin-dependent kinase 6", "Cyclin-dependent-like kinase 5", "Cyclin-g-associated kinase", "Cystatin-B", "Cysteine and glycine-rich protein 2", "Cysteine and histidine-rich domain-containing protein 1", "Cysteine protease", "Cysteine protease ATG4B", "Cysteine protease inhibitor", "Cysteine--tRNA ligase, cytoplasmic", "Cytochrome b-c1 complex subunit 1, mitochondrial", "Cytochrome b-c1 complex subunit 2, mitochondrial", "Cytochrome b-c1 complex subunit 9", "Cytochrome b5 type B", "Cytochrome c oxidase subunit 2", "Cytochrome c oxidase subunit 5A, mitochondrial", "Cytochrome c oxidase subunit 5B, mitochondrial", "Cytochrome c oxidase subunit 7A2, mitochondrial", "Cytochrome c oxidase subunit 7C, mitochondrial", "Cytochrome c oxidase subunit NDUFA4", "Cytochrome c-type heme lyase", "Cytokine", "Cytoplasmic FMR1-interacting protein 1", "Cytoplasmic aconitate hydratase", "Cytoplasmic dynein 1 heavy chain 1", "Cytoplasmic dynein 1 intermediate chain 2", "Cytoplasmic dynein 1 light intermediate chain 1", "Cytoskeleton-associated protein 5", "Cytosol aminopeptidase", "Cytosolic acyl coenzyme A thioester hydrolase", "Cytosolic non-specific dipeptidase", "Cytosolic purine 5'-nucleotidase", "D-3-phosphoglycerate dehydrogenase", "DCK/DGK family", "DDB1- and CUL4-associated factor 13", "DMPK family", "DNA (cytosine-5)-methyltransferase 1", "DNA binding protein", "DNA damage-binding protein 1", "DNA helicase", "DNA ligase", "DNA ligase 3", "DNA methyltransferase", "DNA mismatch repair protein Msh2", "DNA mismatch repair protein Msh3", "DNA mismatch repair protein Msh6", "DNA polymerase processivity factor", "DNA primase small subunit", "DNA replication complex GINS protein PSF1", "DNA replication licensing factor MCM2", "DNA replication licensing factor MCM3", "DNA replication licensing factor MCM4", "DNA replication licensing factor MCM5", "DNA replication licensing factor MCM6", "DNA replication licensing factor MCM7", "DNA topoisomerase", "DNA topoisomerase 1", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "DNA-directed RNA polymerase I subunit RPA1", "DNA-directed RNA polymerase I subunit RPA2", "DNA-directed RNA polymerase II subunit RPB1", "DNA-directed RNA polymerase II subunit RPB2", "DNA-directed RNA polymerase II subunit RPB7", "DNA-directed RNA polymerase III subunit RPC1", "DNA-directed RNA polymerase III subunit RPC3", "DNA-directed RNA polymerase, mitochondrial", "DNA-directed RNA polymerases I and III subunit RPAC1", "DNA-directed RNA polymerases I, II, and III subunit RPABC1", "DNAPK subfamily", "DYRK family", "Damaged DNA-binding protein", "Deacetylase", "Deaminase", "Death-inducer obliterator 1", "Decarboxylase", "Dedicator of cytokinesis protein 7", "Dehydratase", "Dehydrogenase", "Delta(24)-sterol reductase", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial", "Delta-1-pyrroline-5-carboxylate synthase", "Density-regulated protein", "Deoxyguanosine kinase, mitochondrial", "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial", "Derlin-1", "Desmoglein-2", "Desmoplakin", "Digestive organ expansion factor homolog", "Dihydrofolate reductase", "Dihydrolipoyl dehydrogenase, mitochondrial", "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "Dihydropyrimidinase-related protein 2", "Dipeptidyl peptidase 3", "Dipeptidyl peptidase 9", "Dna-dependent protein kinase catalytic subunit", "Dolichol-phosphate mannosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B", "Double-stranded RNA-specific adenosine deaminase", "Drebrin", "Drebrin-like protein", "Dual specificity mitogen-activated protein kinase kinase 1", "Dual specificity protein kinase ttk", "Dynactin subunit 1", "Dynactin subunit 2", "Dynamin-1-like protein", "Dynamin-2", "Dynamin-like 120 kDa protein, mitochondrial", "Dynein light chain 1, cytoplasmic", "Dystonin", "E3 SUMO-protein ligase RanBP2", "E3 ubiquitin-protein ligase ARIH1", "E3 ubiquitin-protein ligase ARIH2", "E3 ubiquitin-protein ligase HUWE1", "E3 ubiquitin-protein ligase Itchy homolog", "E3 ubiquitin-protein ligase NEDD4-like", "E3 ubiquitin-protein ligase RBBP6", "E3 ubiquitin-protein ligase listerin", "EH domain-containing protein 1", "ELKS/Rab6-interacting/CAST family member 1", "ELMO domain-containing protein 2", "ER lumen protein-retaining receptor 1", "ER membrane protein complex subunit 2", "ERO1-like protein alpha", "Electron transfer flavoprotein subunit alpha, mitochondrial", "Electron transfer flavoprotein subunit beta", "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial", "Elongation factor 1-alpha 2", "Elongation factor 1-beta", "Elongation factor 1-delta", "Elongation factor 2", "Elongation factor Ts, mitochondrial", "Elongation factor Tu, mitochondrial", "Elongation factor-like GTPase 1", "Elongator complex protein 1", "Elongin-B", "Endoplasmic reticulum aminopeptidase 1", "Endoplasmic reticulum aminopeptidase 2", "Endoplasmic reticulum protein SC65", "Endoplasmic reticulum resident protein 29", "Endoplasmin", "Endoribonuclease", "Endothelin-converting enzyme 1", "Enhancer of mRNA-decapping protein 4", "Enhancer of rudimentary homolog", "Enoyl-CoA delta isomerase 2, mitochondrial", "Enoyl-CoA hydratase, mitochondrial", "Enzyme", "Enzyme modulator", "Eph family", "Ephrin type-a receptor 7", "Epigenetic regulator", "Epimerase family protein SDR39U1", "Epimerase/racemase", "Epiplakin", "Eraser", "Esterase", "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A", "Eukaryotic peptide chain release factor subunit 1", "Eukaryotic translation initiation factor 2 subunit 1", "Eukaryotic translation initiation factor 2 subunit 2", "Eukaryotic translation initiation factor 2A", "Eukaryotic translation initiation factor 3 subunit A", "Eukaryotic translation initiation factor 3 subunit B", "Eukaryotic translation initiation factor 3 subunit D", "Eukaryotic translation initiation factor 3 subunit E", "Eukaryotic translation initiation factor 3 subunit F", "Eukaryotic translation initiation factor 3 subunit H", "Eukaryotic translation initiation factor 3 subunit I", "Eukaryotic translation initiation factor 3 subunit J", "Eukaryotic translation initiation factor 3 subunit L", "Eukaryotic translation initiation factor 4 gamma 1", "Eukaryotic translation initiation factor 4 gamma 2", "Eukaryotic translation initiation factor 4 gamma 3", "Eukaryotic translation initiation factor 4B", "Eukaryotic translation initiation factor 4E", "Eukaryotic translation initiation factor 4H", "Eukaryotic translation initiation factor 5", "Eukaryotic translation initiation factor 5A-1", "Eukaryotic translation initiation factor 5B", "Eukaryotic translation initiation factor 6", "Exocyst complex component 3", "Exocyst complex component 5", "Exocyst complex component 7", "Exodeoxyribonuclease", "Exonuclease 1", "Exoribonuclease", "Exosome complex component CSL4", "Exosome complex component MTR3", "Exosome complex component RRP40", "Exosome complex component RRP42", "Exosome complex component RRP46", "Exosome complex exonuclease RRP44", "Exportin-1", "Exportin-2", "Exportin-4", "Exportin-5", "Exportin-7", "Extracellular matrix glycoprotein", "Extracellular structure", "Ezrin", "F-actin-capping protein subunit alpha-1", "F-actin-capping protein subunit alpha-2", "F-actin-capping protein subunit beta", "F-type ATPase", "F-type and V-type ATPases", "FACT complex subunit SPT16", "FRAP subfamily", "Far upstream element-binding protein 1", "Far upstream element-binding protein 2", "Far upstream element-binding protein 3", "Farnesyl pyrophosphate synthase", "Fascin", "Fatty acid synthase", "Ferrochelatase, mitochondrial", "Flap endonuclease 1", "Folate transporter 1", "Forkhead box protein C1", "Fragile X mental retardation syndrome-related protein 1", "Fragile X mental retardation syndrome-related protein 2", "Fumarate hydratase, mitochondrial", "G patch domain-containing protein 4", "G-protein", "G-protein coupled receptor", "G-protein modulator", "G-rich sequence factor 1", "GDP-L-fucose synthase", "GMP synthase [glutamine-hydrolyzing]", "GSK family", "GSK subfamily", "GTP-binding nuclear protein Ran", "GTP-binding protein 1", "GTPase Era, mitochondrial", "GTPase-activating protein and VPS9 domain-containing protein 1", "Galactokinase", "Galactosidase", "Gamma-adducin", "Gamma-glutamyl hydrolase", "Gamma-taxilin", "Gamma-tubulin complex component 2", "Gamma-tubulin complex component 3", "Ganglioside GM2 activator", "General transcription factor 3C polypeptide 3", "General transcription factor 3C polypeptide 5", "General vesicular transport factor p115", "Geranylgeranyl transferase type-2 subunit alpha", "Glucosamine-6-phosphate isomerase 1", "Glucose-6-phosphate 1-dehydrogenase", "Glucose-6-phosphate isomerase", "Glucosidase", "Glucosidase 2 subunit beta", "Glutamate dehydrogenase 1, mitochondrial", "Glutaminase kidney isoform, mitochondrial", "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1", "Glutamine--tRNA ligase", "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial", "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial", "Glutaredoxin-3", "Glutaredoxin-related protein 5, mitochondrial", "Glutathione reductase, mitochondrial", "Glutathione synthetase", "Glyceraldehyde-3-phosphate dehydrogenase", "Glycerol-3-phosphate dehydrogenase, mitochondrial", "Glycerol-3-phosphate phosphatase", "Glycine dehydrogenase (decarboxylating), mitochondrial", "Glycine--tRNA ligase", "Glycogen debranching enzyme", "Glycogen phosphorylase, brain form", "Glycogen phosphorylase, liver form", "Glycogen synthase kinase-3 alpha", "Glycogen synthase kinase-3 beta", "Glycosidase", "Glycosyltransferase", "Glycylpeptide N-tetradecanoyltransferase 1", "Glyoxylate reductase/hydroxypyruvate reductase", "Growth factor", "GrpE protein homolog 1, mitochondrial", "Guanine nucleotide-binding protein G(i) subunit alpha-2", "Guanine nucleotide-binding protein G(k) subunit alpha", "Guanine nucleotide-binding protein subunit alpha-13", "Guanyl-nucleotide exchange factor", "H(+)/Cl(-) exchange transporter 3", "H/ACA ribonucleoprotein complex subunit 1", "H/ACA ribonucleoprotein complex subunit 2", "HBS1-like protein", "HDAC class I", "HDAC class III", "HEAT repeat-containing protein 1", "Haloacid dehalogenase-like hydrolase domain-containing 5", "Heat shock protein 75 kDa, mitochondrial", "Heat shock protein HSP 90-alpha", "Heat shock protein HSP 90-beta", "Helicase", "Helix-turn-helix transcription factor", "Hepatoma-derived growth factor", "Hepatoma-derived growth factor-related protein 2", "Heterogeneous nuclear ribonucleoprotein F", "Heterogeneous nuclear ribonucleoprotein H", "Heterogeneous nuclear ribonucleoprotein H2", "Heterogeneous nuclear ribonucleoprotein H3", "Heterogeneous nuclear ribonucleoprotein K", "Heterogeneous nuclear ribonucleoprotein M", "Heterogeneous nuclear ribonucleoprotein Q", "Heterogeneous nuclear ribonucleoprotein R", "Heterotrimeric G-protein", "Hexokinase family", "Hexokinase-1", "Hexokinase-2", "High mobility group protein B1", "High mobility group protein B2", "High mobility group protein B3", "High mobility group protein HMG-I/HMG-Y", "Histidine triad nucleotide-binding protein 2, mitochondrial", "Histone", "Histone H1.0", "Histone H1.2", "Histone H1.3", "Histone H1.4", "Histone H1x", "Histone H2AX", "Histone H4", "Histone acetyltransferase type B catalytic subunit", "Histone deacetylase", "Histone deacetylase 1", "Histone deacetylase 2", "Histone deacetylase complex subunit SAP18", "Histone-arginine methyltransferase CARM1", "Histone-lysine N-methyltransferase NSD2", "Histone-lysine N-methyltransferase SMYD3", "Hormone", "Hsp90 co-chaperone Cdc37", "Hsp90 family chaperone", "Hydrolase", "Hydroxylase", "Hydroxymethylglutaryl-CoA lyase, mitochondrial", "Hypoxanthine-guanine phosphoribosyltransferase", "ILK subfamily", "Immune response", "Immunoglobulin fold transcription factor", "Immunoglobulin-binding protein 1", "Importin subunit alpha-1", "Importin subunit alpha-3", "Importin subunit alpha-4", "Importin subunit alpha-5", "Importin subunit beta-1", "Importin-11", "Importin-4", "Importin-5", "Importin-7", "Importin-8", "Importin-9", "Inactive serine/threonine-protein kinase vrk3", "Inactive tyrosine-protein kinase 7", "Induced myeloid leukemia cell differentiation protein Mcl-1", "Inorganic pyrophosphatase", "Inorganic pyrophosphatase 2, mitochondrial", "Inosine triphosphate pyrophosphatase", "Inosine-5'-monophosphate dehydrogenase 2", "Insulin-degrading enzyme", "Insulin-like growth factor 2 mRNA-binding protein 1", "Insulin-like growth factor 2 mRNA-binding protein 3", "Integrator complex subunit 11", "Integrin beta-1", "Integrin-linked kinase-associated serine/threonine phosphatase 2C", "Integrin-linked protein kinase", "Interferon-induced, double-stranded rna-activated protein kinase", "Interleukin enhancer-binding factor 3", "Intermediate filament", "Intermediate filament binding protein", "Intracellular calcium-sensing protein", "Intracellular chloride channel (clic) family", "Ion channel", "Isoaspartyl peptidase/L-asparaginase", "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial", "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial", "Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial", "Isoleucine--tRNA ligase, cytoplasmic", "Isoleucine--tRNA ligase, mitochondrial", "Isomerase", "Isopentenyl-diphosphate Delta-isomerase 1", "Isovaleryl-CoA dehydrogenase, mitochondrial", "Jumonji domain-containing", "KH domain-containing, RNA-binding, signal transduction-associated protein 1", "KRAB box transcription factor", "KRR1 small subunit processome component homolog", "Ketosamine-3-kinase", "Kinase", "Kinase activator", "Kinase inhibitor", "Kinase modulator", "Kinesin-1 heavy chain", "Kinesin-like protein KIF11", "Kinesin-like protein KIF14", "Kinesin-like protein KIF22", "Kinesin-like protein KIF23", "Kinesin-like protein KIF2A", "Kinesin-like protein KIF2C", "Kinesin-like protein KIFC1", "Kynurenine--oxoglutarate transaminase 3", "L-2-hydroxyglutarate dehydrogenase, mitochondrial", "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase", "L-lactate dehydrogenase A chain", "L-lactate dehydrogenase B chain", "LIM domain and actin-binding protein 1", "LU7TM family", "La-related protein 1", "La-related protein 4", "La-related protein 4B", "La-related protein 7", "Lamin-B receptor", "Lamina-associated polypeptide 2, isoform alpha", "Lanosterol 14-alpha demethylase", "Large proline-rich protein BAG6", "Legumain", "Lethal(2) giant larvae protein homolog 1", "Leucine-rich repeat and WD repeat-containing protein 1", "Leucine-rich repeat-containing protein 47", "Leucyl-cystinyl aminopeptidase", "Ligase", "Lipase", "Lipid kinase", "Lon protease homolog, mitochondrial", "Long-chain fatty acid transport protein 4", "Long-chain-fatty-acid--CoA ligase 1", "Long-chain-fatty-acid--CoA ligase 3", "Long-chain-fatty-acid--CoA ligase 4", "Lupus La protein", "Lyase", "Lymphokine-activated killer t-cell-originated protein kinase", "Lysine demethylase", "Lysine--tRNA ligase", "Lysine-specific demethylase", "Lysine-specific demethylase 3B", "Lysine-specific histone demethylase 1A", "Lysine-specific histone demethylase 1B", "Lysophosphatidic acid phosphatase type 6", "Lysophosphatidylcholine acyltransferase 1", "Lysophospholipid acyltransferase 7", "Lysosomal Pro-X carboxypeptidase", "Lysosomal acid lipase/cholesteryl ester hydrolase", "Lysosomal acid phosphatase", "Lysosomal alpha-glucosidase", "Lysosomal protective protein", "Lysosome membrane protein 2", "Lysosome-associated membrane glycoprotein 1", "MAGUK p55 subfamily member 2", "MAGUK p55 subfamily member 6", "MARK subfamily", "MFS-type transporter SLC18B1", "MLK family", "MMS19 nucleotide excision repair protein homolog", "MOB-like protein phocein", "Magnesium transporter protein 1", "Major histocompatibility complex antigen", "Malate dehydrogenase, cytoplasmic", "Malate dehydrogenase, mitochondrial", "Malignant T-cell-amplified sequence 1", "Mannose-6-phosphate isomerase", "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "Melanoma-associated antigen D2", "Membrane trafficking regulatory protein", "Membrane-associated progesterone receptor component 1", "Membrane-associated progesterone receptor component 2", "Metalloprotease", "Metastasis-associated protein MTA1", "Metastasis-associated protein MTA2", "Methyl-CpG-binding domain", "Methyl-CpG-binding protein 2", "Methyl-lysine/arginine binding protein", "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial", "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial", "Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial", "Methylosome subunit pICln", "Methyltransferase", "Microsomal glutathione S-transferase 2", "Microsomal glutathione S-transferase 3", "Microtubule binding motor protein", "Microtubule family cytoskeletal protein", "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5", "Microtubule-associated protein 1B", "Microtubule-associated protein 1S", "Microtubule-associated protein RP/EB family member 1", "Microtubule-associated protein RP/EB family member 2", "Minor histocompatibility antigen H13", "Miscellaneous SLC25 mitochondrial transporters", "Mitochondrial 2-oxoglutarate/malate carrier protein", "Mitochondrial Rho GTPase 1", "Mitochondrial Rho GTPase 2", "Mitochondrial amino acid transporter subfamily", "Mitochondrial carnitine/acylcarnitine carrier protein", "Mitochondrial carrier homolog 1", "Mitochondrial carrier homolog 2", "Mitochondrial di- and tri-carboxylic acid transporter subfamily", "Mitochondrial dicarboxylate carrier", "Mitochondrial folate transporter/carrier", "Mitochondrial import receptor subunit TOM20 homolog", "Mitochondrial import receptor subunit TOM40 homolog", "Mitochondrial intermediate peptidase", "Mitochondrial nucleotide transporter subfamily", "Mitochondrial ornithine transporter 1", "Mitochondrial phosphate transporters", "Mitochondrial proton/calcium exchanger protein", "Mitochondrial thiamine pyrophosphate carrier", "Mitochondrial-processing peptidase subunit alpha", "Mitochondrial-processing peptidase subunit beta", "Mitofusin-1", "Mitofusin-2", "Mitotic checkpoint protein BUB3", "Mitotic checkpoint serine/threonine-protein kinase bub1 beta", "Moesin", "Monoacylglycerol lipase ABHD12", "Monoacylglycerol lipase ABHD6", "Monocarboxylate transporter 1", "Monofunctional C1-tetrahydrofolate synthase, mitochondrial", "Mortality factor 4-like protein 1", "Mpv17-like protein 2", "Multidrug resistance protein 1", "Multidrug resistance-associated protein 4", "Multifunctional protein ADE2", "Mutase", "Myb-binding protein 1A", "Myelin expression factor 2", "Myosin light polypeptide 6", "Myosin phosphatase Rho-interacting protein", "Myotubularin-related protein 6", "N-acetyl-D-glucosamine kinase", "N-acetylglucosamine-6-sulfatase", "N-acylneuraminate cytidylyltransferase", "N-alpha-acetyltransferase 15, NatA auxiliary subunit", "N-alpha-acetyltransferase 25, NatB auxiliary subunit", "N-alpha-acetyltransferase 35, NatC auxiliary subunit", "N-alpha-acetyltransferase 50", "N-terminal Xaa-Pro-Lys N-methyltransferase 1", "NAD kinase 2, mitochondrial", "NAD(P) transhydrogenase, mitochondrial", "NAD-dependent malic enzyme, mitochondrial", "NAD-dependent protein deacetylase sirtuin-2", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial", "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial", "NADP-dependent malic enzyme", "NAK family", "NEDD8-activating enzyme E1 catalytic subunit", "NEK family", "NF-kappa-B-repressing factor", "NHP2-like protein 1", "NRBP family", "NSFL1 cofactor p47", "Na+/K+-ATPases", "Nardilysin", "Neuferricin", "Neurolysin, mitochondrial", "Neuropathy target esterase", "Neuroplastin", "Neutral alpha-glucosidase AB", "Neutral amino acid transporter B(0)", "Neutral amino acid transporter subfamily", "Nicotinamide phosphoribosyltransferase", "Nipped-B-like protein", "Nischarin", "Non-POU domain-containing octamer-binding protein", "Non-motor actin binding protein", "Non-motor microtubule binding protein", "Non-protein kinase", "Nuclear RNA export factor 1", "Nuclear cap-binding protein subunit 1", "Nuclear migration protein nudC", "Nuclear pore complex protein Nup107", "Nuclear pore complex protein Nup153", "Nuclear pore complex protein Nup160", "Nuclear pore complex protein Nup214", "Nuclear pore complex protein Nup85", "Nuclear pore complex protein Nup88", "Nuclear pore complex protein Nup93", "Nuclear pore complex protein Nup98-Nup96", "Nuclear pore glycoprotein p62", "Nuclear pore membrane glycoprotein 210", "Nuclear receptor coactivator 5", "Nuclear receptor-binding protein", "Nuclease", "Nucleic acid binding", "Nucleobindin-1", "Nucleobindin-2", "Nucleolar MIF4G domain-containing protein 1", "Nucleolar complex protein 4 homolog", "Nucleolar protein 56", "Nucleolar protein 58", "Nucleolar protein 6", "Nucleolin", "Nucleophosmin", "Nucleoporin GLE1", "Nucleoporin Nup37", "Nucleoporin SEH1", "Nucleoporin p54", "Nucleoside diphosphate kinase A", "Nucleoside kinase", "Nucleosome assembly protein 1-like 1", "Nucleosome assembly protein 1-like 4", "Nucleotide kinase", "Nucleotide phosphatase", "Nucleotidyltransferase", "NudC domain-containing protein 2", "OCIA domain-containing protein 1", "Obg-like ATPase 1", "Occludin", "Ornithine aminotransferase, mitochondrial", "Other 7TM proteins", "Other group", "Other small molecule kinase", "Oxidase", "Oxidoreductase", "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial", "Oxygenase", "P-type ATPases", "P53-like transcription factor", "PAKA subfamily", "PAKB subfamily", "PC4 and SFRS1-interacting protein", "PDHK family", "PDZ and LIM domain protein 1", "PDZ and LIM domain protein 5", "PDZ and LIM domain protein 7", "PEK family", "PH-interacting protein", "PHD finger protein 6", "PI3/PI4 kinase family", "PIKK family", "PKA family", "PKN family", "PLK family", "Paired amphipathic helix protein Sin3a", "Palmitoyl-protein thioesterase 1", "Pantothenate kinase 4", "Paraspeckle component 1", "Pentatricopeptide repeat-containing protein 1, mitochondrial", "Peptidase M20 domain-containing protein 2", "Peptidyl-prolyl cis-trans isomerase FKBP4", "Peptidyl-prolyl cis-trans isomerase FKBP5", "Peptidyl-prolyl cis-trans isomerase-like 1", "Perilipin-3", "Periodic tryptophan protein 1 homolog", "Peroxidase", "Peroxiredoxin-2", "Peroxiredoxin-4", "Peroxiredoxin-6", "Peroxisomal NADH pyrophosphatase NUDT12", "Peroxisomal acyl-coenzyme A oxidase 1", "Peroxisomal membrane protein 2", "Peroxisomal membrane protein PEX14", "Peroxisomal membrane protein PMP34", "Peroxisomal trans-2-enoyl-CoA reductase", "Pescadillo homolog", "Phenylalanine--tRNA ligase beta subunit", "Phosphatase", "Phosphatase activator", "Phosphatase inhibitor", "Phosphatase modulator", "Phosphate carrier protein, mitochondrial", "Phosphatidylethanolamine-binding protein 1", "Phosphatidylinositol 4-kinase beta", "Phosphatidylinositol transfer protein alpha isoform", "Phosphatidylinositol transfer protein beta isoform", "Phosphatidylinositol-binding clathrin assembly protein", "Phosphatidylserine synthase 1", "Phosphodiesterase", "Phosphofructokinase type A (PFKA) family", "Phosphoglycerate kinase 1", "Phosphoglycerate kinase family", "Phospholipase", "Phospholipase A-2-activating protein", "Phosphoribosyl pyrophosphate synthase-associated protein 1", "Phosphoribosyl pyrophosphate synthase-associated protein 2", "Phosphorylase", "Phosphorylated adapter RNA export protein", "Pirin", "Plasma membrane calcium-transporting ATPase 1", "Plasma membrane calcium-transporting ATPase 4", "Plasminogen activator inhibitor 1 RNA-binding protein", "Plastin-1", "Plastin-3", "Plectin", "Pogo transposable element with ZNF domain", "Poly(A) RNA polymerase, mitochondrial", "Poly(A) polymerase alpha", "Poly(A)-specific ribonuclease PARN", "Poly(ADP-ribose) glycohydrolase", "Poly(rC)-binding protein 1", "Poly(rC)-binding protein 2", "Polycomb protein SUZ12", "Polyglutamine-binding protein 1", "Polyhomeotic-like protein 2", "Polymerase", "Polymerase delta-interacting protein 3", "Polypeptide N-acetylgalactosaminyltransferase 1", "Polypeptide N-acetylgalactosaminyltransferase 2", "Polyribonucleotide nucleotidyltransferase 1, mitochondrial", "Pre-mRNA-processing factor 6", "Pre-mRNA-processing-splicing factor 8", "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15", "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16", "Pre-mRNA-splicing factor RBM22", "Pre-mRNA-splicing factor SPF27", "Pre-mRNA-splicing factor SYF1", "Prefoldin subunit 2", "Prefoldin subunit 3", "Prefoldin subunit 5", "Presequence protease, mitochondrial", "Primase", "Probable 18S rRNA (guanine-N(7))-methyltransferase", "Probable ATP-dependent RNA helicase DHX37", "Probable ATP-dependent RNA helicase DHX40", "Probable RNA-binding protein 19", "Probable U3 small nucleolar RNA-associated protein 11", "Probable global transcription activator SNF2L1", "Probable leucine--tRNA ligase, mitochondrial", "Probable serine carboxypeptidase CPVL", "Procollagen galactosyltransferase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2", "Programmed cell death 6-interacting protein", "Programmed cell death protein 4", "Programmed cell death protein 5", "Prolactin regulatory element-binding protein", "Proliferating cell nuclear antigen", "Prolyl 3-hydroxylase 1", "Prolyl endopeptidase", "Propionyl-CoA carboxylase alpha chain, mitochondrial", "Propionyl-CoA carboxylase beta chain, mitochondrial", "Prostaglandin E synthase 2", "Prostaglandin E synthase 3", "Prostaglandin reductase 1", "Prostaglandin reductase 2", "Prostaglandin reductase 3", "Protease", "Protease inhibitor", "Protein AATF", "Protein CMSS1", "Protein DDI1 homolog 2", "Protein ERGIC-53", "Protein FRG1", "Protein LSM14 homolog B", "Protein NDRG3", "Protein PRRC2A", "Protein PRRC2B", "Protein PRRC2C", "Protein RRP5 homolog", "Protein Red", "Protein S100-A10", "Protein S100-A11", "Protein SCAF8", "Protein SCO1 homolog, mitochondrial", "Protein SET", "Protein Wiz", "Protein XRP2", "Protein arginine N-methyltransferase 1", "Protein arginine N-methyltransferase 3", "Protein arginine N-methyltransferase 5", "Protein arginine methyltransferase", "Protein farnesyltransferase subunit beta", "Protein gpr107", "Protein kinase", "Protein kinase C and casein kinase substrate in neurons protein 2", "Protein methyltransferase", "Protein phosphatase", "Protein phosphatase 1G", "Protein phosphatase methylesterase 1", "Protein polybromo-1", "Protein quaking", "Protein regulator of cytokinesis 1", "Protein transport protein Sec23A", "Protein transport protein Sec24A", "Protein transport protein Sec24B", "Protein transport protein Sec24C", "Protein transport protein Sec31A", "Protein transport protein Sec61 subunit alpha isoform 1", "Protein tweety homolog 3", "Protein unc-119 homolog B", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase", "Protein/nucleic acid deglycase DJ-1", "Purine nucleoside phosphorylase", "Puromycin-sensitive aminopeptidase", "Putative oxidoreductase GLYR1", "Putative phospholipase B-like 2", "Pyrophosphatase", "Pyruvate carboxylase, mitochondrial", "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial", "Pyruvate dehydrogenase protein X component, mitochondrial", "Pyruvate kinase pkm", "RIO family", "RIO2 subfamily", "RIPK family", "RNA 3'-terminal phosphate cyclase-like protein", "RNA binding protein", "RNA helicase", "RNA polymerase II subunit A C-terminal domain phosphatase SSU72", "RNA-binding motif protein, X chromosome", "RNA-binding protein 12", "RNA-binding protein 14", "RNA-binding protein 26", "RNA-binding protein 27", "RNA-binding protein 4", "RNA-binding protein EWS", "RNA-binding protein FUS", "RNA-binding protein with serine-rich domain 1", "ROCK subfamily", "RSK family", "RSK subfamily", "Rab GDP dissociation inhibitor alpha", "Rab GDP dissociation inhibitor beta", "Rab GTPase-activating protein 1", "Rab3 GTPase-activating protein non-catalytic subunit", "Rac-beta serine/threonine-protein kinase", "Radixin", "RalBP1-associated Eps domain-containing protein 1", "Ran GTPase-activating protein 1", "Ran-binding protein 3", "Ran-binding protein 9", "Ran-specific GTPase-activating protein", "Ras GTPase-activating protein-binding protein 1", "Ras GTPase-activating protein-binding protein 2", "Ras GTPase-activating-like protein IQGAP1", "Ras-related C3 botulinum toxin substrate 1", "Ras-related protein Ral-A", "Reader", "Receptor", "Receptor expression-enhancing protein 5", "Receptor-interacting serine/threonine-protein kinase 1", "Reductase", "Regulation of nuclear pre-mRNA domain-containing protein 1A", "Regulation of nuclear pre-mRNA domain-containing protein 2", "Regulator of nonsense transcripts 1", "Remodeling and spacing factor 1", "Replication factor C subunit 2", "Replication factor C subunit 3", "Replication factor C subunit 4", "Replication factor C subunit 5", "Replication protein A 70 kDa DNA-binding subunit", "Reticulocalbin-1", "Reticulocalbin-2", "Retinal dehydrogenase 2", "Retinoid-inducible serine carboxypeptidase", "Retinol dehydrogenase 11", "Rho GDP-dissociation inhibitor 1", "Rho-associated protein kinase 2", "Rho-related GTP-binding protein RhoG", "Ribonuclease H2 subunit A", "Ribonuclease P protein subunit p30", "Ribonucleoprotein", "Ribonucleoprotein PTB-binding 1", "Ribonucleoside-diphosphate reductase large subunit", "Ribonucleoside-diphosphate reductase subunit M2", "Ribosomal L1 domain-containing protein 1", "Ribosomal RNA small subunit methyltransferase NEP1", "Ribosomal RNA-processing protein 7 homolog A", "Ribosomal protein", "Ribosomal protein s6 kinase alpha-1", "Ribosomal protein s6 kinase alpha-3", "Ribosome biogenesis protein BOP1", "Ribosome biogenesis protein BRX1 homolog", "Ribosome biogenesis regulatory protein homolog", "Ribosome maturation protein SBDS", "Ribosome production factor 2 homolog", "Ribosome-recycling factor, mitochondrial", "S-adenosylhomocysteine hydrolase-like protein 1", "S-adenosylmethionine mitochondrial carrier protein", "S-adenosylmethionine synthase isoform type-2", "S-formylglutathione hydrolase", "S-methyl-5'-thioadenosine phosphorylase", "S-phase kinase-associated protein 1", "SAP30-binding protein", "SEC23-interacting protein", "SET domain", "SLC superfamily of solute carriers", "SLC1 family of amino acid transporters", "SLC12 family of cation-coupled chloride transporters", "SLC16 family of monocarboxylate transporters", "SLC18 family of vesicular amine transporters", "SLC19 family of vitamin transporters", "SLC25 family of mitochondrial transporters", "SLC27 family of fatty acid transporters", "SLC3 and SLC7 families of heteromeric amino acid transporters (HATs)", "SLC3 family", "SLC33 acetylCoA transporter", "SLC35 family of nucleotide sugar transporters", "SLC55 Mitochondrial cation/proton exchangers", "SLC56 Sideroflexins", "SLC58 MagT-like magnesium transporter family", "SLC6 neurotransmitter transporter family", "SLK subfamily", "SNARE protein", "SNW domain-containing protein 1", "SRPK family", "STE group", "STE20 family", "STE7 family", "SUMO-activating enzyme subunit 1", "SUMO-activating enzyme subunit 2", "SWI/SNF complex subunit SMARCC1", "SWI/SNF complex subunit SMARCC2", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1", "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "Scavenger receptor class B member 1", "Sec1 family domain-containing protein 1", "Secretory carrier-associated membrane protein 1", "Secretory carrier-associated membrane protein 2", "Secretory carrier-associated membrane protein 3", "Selenide, water dikinase 1", "Sentrin-specific protease 3", "Septin-2", "Septin-7", "Septin-9", "Serine hydroxymethyltransferase, cytosolic", "Serine hydroxymethyltransferase, mitochondrial", "Serine palmitoyltransferase 1", "Serine protease", "Serine protease inhibitor", "Serine--tRNA ligase, cytoplasmic", "Serine--tRNA ligase, mitochondrial", "Serine/arginine repetitive matrix protein 1", "Serine/arginine-rich splicing factor 1", "Serine/arginine-rich splicing factor 10", "Serine/arginine-rich splicing factor 11", "Serine/arginine-rich splicing factor 2", "Serine/arginine-rich splicing factor 3", "Serine/arginine-rich splicing factor 4", "Serine/arginine-rich splicing factor 5", "Serine/arginine-rich splicing factor 7", "Serine/arginine-rich splicing factor 9", "Serine/threonine-protein kinase mark2", "Serine/threonine-protein kinase mtor", "Serine/threonine-protein kinase n2", "Serine/threonine-protein kinase nek9", "Serine/threonine-protein kinase pak 2", "Serine/threonine-protein kinase pak 4", "Serine/threonine-protein kinase plk1", "Serine/threonine-protein kinase prp4 homolog", "Serine/threonine-protein kinase rio2", "Serine/threonine-protein kinase vrk1", "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "Serine/threonine-protein phosphatase 2A activator", "Serine/threonine-protein phosphatase 6 regulatory subunit 3", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit", "Serpin B6", "Serpin H1", "Sialic acid synthase", "Sialidase-1", "Sideroflexin-1", "Sigma intracellular receptor 2", "Signal peptidase complex catalytic subunit SEC11A", "Signal peptidase complex subunit 2", "Signal peptidase complex subunit 3", "Signal recognition particle 14 kDa protein", "Signal recognition particle 19 kDa protein", "Signal recognition particle 54 kDa protein", "Signal recognition particle 9 kDa protein", "Signal recognition particle receptor subunit alpha", "Signal recognition particle subunit SRP68", "Signal transducer and activator of transcription 3", "Signaling", "Single-stranded DNA-binding protein, mitochondrial", "Sister chromatid cohesion protein PDS5 homolog A", "Sister chromatid cohesion protein PDS5 homolog B", "Small GTPase", "Small nuclear ribonucleoprotein E", "Small nuclear ribonucleoprotein Sm D1", "Small nuclear ribonucleoprotein Sm D2", "Small nuclear ribonucleoprotein Sm D3", "Sodium-dependent neutral amino acid transporter B(0)AT2", "Sodium/potassium-transporting ATPase subunit alpha-1", "Sodium/potassium-transporting ATPase subunit beta-1", "Sodium/potassium-transporting ATPase subunit beta-3", "Solute carrier family 12 member 2", "Solute carrier family 25 member 33", "Solute carrier family 35 member F2", "Sortilin", "Sorting nexin-1", "Sorting nexin-2", "Spermatid perinuclear RNA-binding protein", "Spermidine synthase", "Splicing factor 1", "Splicing factor 3A subunit 1", "Splicing factor 3A subunit 2", "Splicing factor 3A subunit 3", "Splicing factor 3B subunit 1", "Splicing factor 3B subunit 3", "Splicing factor 45", "Splicing factor, proline- and glutamine-rich", "Splicing factor, suppressor of white-apricot homolog", "Squalene monooxygenase", "Squamous cell carcinoma antigen recognized by T-cells 3", "Src substrate cortactin", "Srsf protein kinase 1", "Srsf protein kinase 2", "Staphylococcal nuclease domain-containing protein 1", "Ste20-like serine/threonine-protein kinase", "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating", "Stomatin-like protein 2, mitochondrial", "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial", "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial", "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial", "Succinate-semialdehyde dehydrogenase, mitochondrial", "Sulfhydryl oxidase 2", "Superoxide dismutase [Mn], mitochondrial", "Surfeit locus protein 6", "Survival motor neuron protein", "Synaptic functional regulator FMR1", "Synaptogyrin-2", "Synaptosomal-associated protein 29", "Syntaxin-12", "Syntaxin-18", "Syntaxin-7", "Syntaxin-8", "Syntaxin-binding protein 3", "T-complex protein 1 subunit alpha", "T-complex protein 1 subunit beta", "T-complex protein 1 subunit delta", "T-complex protein 1 subunit epsilon", "T-complex protein 1 subunit eta", "T-complex protein 1 subunit gamma", "T-complex protein 1 subunit theta", "T-complex protein 1 subunit zeta", "TATA-binding protein-associated factor 2N", "TBC1 domain family member 10B", "TBC1 domain family member 13", "TBC1 domain family member 15", "TBC1 domain family member 4", "TBC1 domain family member 9B", "THO complex subunit 1", "THO complex subunit 2", "THO complex subunit 3", "THO complex subunit 4", "TK group", "TKL group", "TOPK family", "TP53-binding protein 1", "TTK family", "Target of EGR1 protein 1", "Targeting protein for Xklp2", "Thimet oligopeptidase", "Thioredoxin domain-containing protein 12", "Thioredoxin domain-containing protein 17", "Thioredoxin domain-containing protein 9", "Thioredoxin reductase 1, cytoplasmic", "Thioredoxin-dependent peroxide reductase, mitochondrial", "Threonine--tRNA ligase, cytoplasmic", "Threonine--tRNA ligase, mitochondrial", "Thymidine kinase family", "Thymidine kinase, cytosolic", "Thymidylate kinase", "Thymidylate kinase family", "Thymidylate synthase", "Thyroid hormone receptor-associated protein 3", "Tight junction", "Tight junction protein ZO-1", "Tight junction protein ZO-2", "Transaminase", "Transcription activator BRG1", "Transcription cofactor", "Transcription elongation factor A protein 1", "Transcription elongation factor SPT6", "Transcription elongation regulator 1", "Transcription factor", "Transcriptional activator protein Pur-alpha", "Transcriptional repressor p66-alpha", "Transferase", "Transferrin receptor protein 1", "Transformer-2 protein homolog alpha", "Transformer-2 protein homolog beta", "Transforming protein RhoA", "Transgelin-2", "Transketolase", "Translation elongation factor", "Translation factor", "Translation initiation factor", "Translation initiation factor IF-2, mitochondrial", "Translation release factor", "Translationally-controlled tumor protein", "Translocation protein SEC63 homolog", "Translocon-associated protein subunit alpha", "Transmembrane 9 superfamily member 3", "Transmembrane emp24 domain-containing protein 10", "Transmembrane emp24 domain-containing protein 7", "Transmembrane emp24 domain-containing protein 9", "Transport and Golgi organization protein 1 homolog", "Transporter", "Transportin-1", "Trifunctional enzyme subunit alpha, mitochondrial", "Trifunctional enzyme subunit beta, mitochondrial", "Trifunctional purine biosynthetic protein adenosine-3", "Triosephosphate isomerase", "Tripeptidyl-peptidase 1", "Tripeptidyl-peptidase 2", "Tropomodulin-3", "Tropomyosin alpha-3 chain", "Tryptophan--tRNA ligase, cytoplasmic", "Tuberin", "Tubulin", "Tubulin beta chain", "Tubulin beta-2B chain", "Tubulin beta-4B chain", "Tubulin beta-6 chain", "Tubulin-specific chaperone A", "Tubulin-specific chaperone E", "Tudor and KH domain-containing protein", "Tudor domain", "Tumor susceptibility gene 101 protein", "Twinfilin-1", "Twinfilin-2", "Tyrosine--tRNA ligase, cytoplasmic", "Tyrosine--tRNA ligase, mitochondrial", "Tyrosine-protein kinase csk", "U1 small nuclear ribonucleoprotein 70 kDa", "U1 small nuclear ribonucleoprotein A", "U2 small nuclear ribonucleoprotein A'", "U2 snRNP-associated SURP motif-containing protein", "U3 small nucleolar RNA-associated protein 14 homolog A", "U3 small nucleolar RNA-associated protein 6 homolog", "U3 small nucleolar ribonucleoprotein protein IMP3", "U3 small nucleolar ribonucleoprotein protein MPP10", "U4/U6 small nuclear ribonucleoprotein Prp3", "U4/U6 small nuclear ribonucleoprotein Prp31", "U4/U6 small nuclear ribonucleoprotein Prp4", "U4/U6.U5 tri-snRNP-associated protein 1", "U4/U6.U5 tri-snRNP-associated protein 2", "U6 snRNA-associated Sm-like protein LSm2", "U6 snRNA-associated Sm-like protein LSm6", "UDP-glucose:glycoprotein glucosyltransferase 1", "UMP-CMP kinase", "UV excision repair protein RAD23 homolog B", "Ubiquitin carboxyl-terminal hydrolase 10", "Ubiquitin carboxyl-terminal hydrolase 14", "Ubiquitin carboxyl-terminal hydrolase 36", "Ubiquitin carboxyl-terminal hydrolase 47", "Ubiquitin carboxyl-terminal hydrolase 5", "Ubiquitin carboxyl-terminal hydrolase 7", "Ubiquitin carboxyl-terminal hydrolase 8", "Ubiquitin carboxyl-terminal hydrolase isozyme L5", "Ubiquitin conjugation factor E4 A", "Ubiquitin thioesterase OTUB1", "Ubiquitin-conjugating enzyme E2 L3", "Ubiquitin-like modifier-activating enzyme 1", "Ubiquitin-like modifier-activating enzyme 6", "Ubiquitin-protein ligase", "Unclassified protein", "Unconventional myosin-Ib", "Unconventional myosin-Ic", "Unconventional myosin-VI", "V-type ATPase", "V-type proton ATPase 116 kDa subunit a isoform 1", "V-type proton ATPase 116 kDa subunit a isoform 2", "V-type proton ATPase catalytic subunit A", "V-type proton ATPase subunit B, brain isoform", "V-type proton ATPase subunit C 1", "V-type proton ATPase subunit H", "V-type proton ATPase subunit d 1", "VRK family", "Vacuolar protein sorting-associated protein 18 homolog", "Vacuolar protein sorting-associated protein 26A", "Vacuolar protein sorting-associated protein 29", "Vacuolar protein sorting-associated protein 33A", "Vacuolar protein sorting-associated protein 33B", "Vacuolar protein sorting-associated protein 35", "Vacuolar protein sorting-associated protein 4B", "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial", "Very-long-chain enoyl-CoA reductase", "Vesicle coat protein", "Vesicle-associated membrane protein 7", "Vesicle-associated membrane protein-associated protein A", "Vesicle-associated membrane protein-associated protein B/C", "Vesicle-fusing ATPase", "Vesicular integral-membrane protein VIP36", "WD repeat and HMG-box DNA-binding protein 1", "WD repeat-containing protein 1", "WD repeat-containing protein 82", "Winged helix/forkhead transcription factor", "Writer", "X-ray repair cross-complementing protein 5", "X-ray repair cross-complementing protein 6", "Xaa-Pro dipeptidase", "YEATS domain-containing protein 2", "YEATS domain-containing protein 4", "YLP motif-containing protein 1", "Zinc finger CCCH domain-containing protein 15", "Zinc finger CCCH domain-containing protein 7A", "Zinc finger CCHC domain-containing protein 8", "Zinc finger MYM-type protein 2", "Zinc finger MYM-type protein 4", "Zinc finger RNA-binding protein", "Zinc finger and BTB domain-containing protein 10", "Zinc finger protein 148", "Zinc finger protein 281", "Zinc finger protein ubi-d4", "Zinc finger transcription factor", "Zyxin", "[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial", "eIF-2-alpha kinase activator GCN1", "eukaryotic two domain clade \"e\" sub-subfamily", "m7GpppX diphosphatase", "mRNA export factor", "mRNA polyadenylation factor", "mRNA processing factor", "mRNA splicing factor", "pre-mRNA 3' end processing protein WDR33", "rRNA 2'-O-methyltransferase fibrillarin", "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6", "tRNA (cytosine(34)-C(5))-methyltransferase", "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4", "tRNA pseudouridine synthase A"], "available_proteins": ["AARS", "AARS2", "AARSD1", "AASDHPPT", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCF1", "ABCF2", "ABHD12", "ABHD6", "ACAA2", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT9", "ACOX1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR6", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADPGK", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AHCY", "AHCYL1", "AIFM1", "AIMP1", "AIP", "AK1", "AK2", "AK6", "AKAP1", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALYREF", "ANAPC1", "ANP32B", "ANP32E", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APLP2", "APOL2", "APP", "ARCN1", "ARG2", "ARHGDIA", "ARIH1", "ARIH2", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ASRGL1", "ATAD3A", "ATAD3B", "ATG4B", "ATIC", "ATL2", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1H", "ATPIF1", "ATXN2L", "AUP1", "BAG6", "BAIAP2", "BCAP31", "BCAS2", "BCAT2", "BCLAF1", "BLMH", "BLVRA", "BOP1", "BRCA1", "BRD2", "BRIX1", "BUB1B", "BUB3", "BUD23", "BZW1", "CACYBP", "CAD", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC37", "CDC42", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CEBPZ", "CECR2", "CEP170", "CFAP20", "CHAF1B", "CHERP", "CHKA", "CHMP3", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CIRBP", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLNS1A", "CLPTM1", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT3", "CNOT6", "CNOT7", "CNP", "COIL", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS3", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1B", "CORO1C", "COTL1", "COX2", "COX5A", "COX5B", "COX7A2", "COX7C", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRNKL1", "CRTAP", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL4A", "CUL4B", "CUL5", "CYB5B", "CYB5D2", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DCAF13", "DCPS", "DCTN1", "DCTN2", "DDB1", "DDI2", "DDOST", "DENR", "DERL1", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX29", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIDO1", "DIEXF", "DIS3", "DLD", "DLST", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPF2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DSG2", "DSP", "DST", "DTYMK", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "ECE1", "ECH1", "ECHS1", "ECI2", "EDC4", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3H", "EIF3I", "EIF3J", "EIF3L", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELMOD2", "ELOB", "ELP1", "EMC2", "EMG1", "ENO1", "EPHA7", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERH", "ERO1A", "ERP29", "ESD", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC3", "EXOC5", "EXOC7", "EXOSC1", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "FAHD1", "FARSB", "FASN", "FBL", "FDPS", "FECH", "FEN1", "FH", "FKBP4", "FKBP5", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FRG1", "FSCN1", "FUBP1", "FUBP3", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GCAT", "GCN1", "GDI1", "GDI2", "GFPT1", "GGH", "GINS1", "GLB1", "GLDC", "GLE1", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNPDA1", "GNS", "GPATCH4", "GPD2", "GPI", "GPR107", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GTF3C3", "GTF3C5", "GTPBP1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HADHA", "HADHB", "HAT1", "HBS1L", "HCCS", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD5", "HEATR1", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HPRT1", "HSD17B10", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HUWE1", "IARS", "IARS2", "IDE", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IGBP1", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMPDH2", "INTS11", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "ITCH", "ITGB1", "ITPA", "IVD", "KARS", "KCTD12", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KHDRBS1", "KHSRP", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRR1", "KYAT3", "L2HGDH", "LAMP1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LETM1", "LGMN", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LRRC47", "LRWD1", "LSM14B", "LSM2", "LSM6", "LTN1", "MACF1", "MAGED2", "MAGT1", "MAP1B", "MAP1S", "MAP2K1", "MAPRE1", "MAPRE2", "MARK2", "MAT2A", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MFN1", "MFN2", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MIPEP", "MMS19", "MOB4", "MORF4L1", "MPHOSPH10", "MPI", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRPL1", "MRPL11", "MRPL12", "MRPL14", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL38", "MRPL39", "MRPL44", "MRPL47", "MRPL48", "MRPL9", "MRPS11", "MRPS2", "MRPS27", "MRPS35", "MRPS5", "MRPS7", "MRRF", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MYBBP1A", "MYEF2", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAA15", "NAA25", "NAA35", "NAA50", "NADK2", "NAGK", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NCAPD2", "NCBP1", "NCL", "NCOA5", "NDRG3", "NDUFA10", "NDUFA4", "NDUFA5", "NDUFA9", "NDUFB11", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS7", "NEDD4L", "NEK9", "NEU1", "NHP2", "NIPBL", "NISCH", "NKRF", "NLN", "NME1", "NMT1", "NNT", "NOC4L", "NOL6", "NOM1", "NONO", "NOP56", "NOP58", "NPEPPS", "NPM1", "NPTN", "NRBP1", "NRDC", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUP107", "NUP153", "NUP160", "NUP210", "NUP214", "NUP37", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCIAD1", "OCLN", "OLA1", "OPA1", "OTUB1", "P3H1", "P3H4", "PACSIN2", "PAICS", "PAK2", "PAK4", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCMT1", "PCNA", "PDCD11", "PDCD4", "PDCD5", "PDCD6IP", "PDE12", "PDHX", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PEBP1", "PECR", "PEPD", "PES1", "PEX14", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PGD", "PGK1", "PGLS", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHC2", "PHF6", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIR", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLAA", "PLBD2", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLDIP3", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PPA1", "PPA2", "PPAT", "PPIL1", "PPM1G", "PPME1", "PPP1CA", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP6R3", "PPT1", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX6", "PREB", "PREP", "PRIM1", "PRKACA", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF3", "PRPF31", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSIP1", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSPC1", "PTCD1", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PURA", "PUS1", "PWP1", "PXMP2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB3GAP2", "RABGAP1", "RABGGTA", "RAC1", "RAD23B", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAVER1", "RBBP6", "RBM12", "RBM14", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM4", "RBMX", "RCL1", "RCN1", "RCN2", "RDH11", "RDX", "RECQL", "RECQL5", "REEP5", "REPS1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIOK2", "RIPK1", "RNASEH2A", "RNPS1", "ROCK2", "RP2", "RPA1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRM1", "RRM2", "RRP7A", "RRS1", "RSF1", "RSL1D1", "S100A10", "S100A11", "SAE1", "SAP18", "SAP30BP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF8", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCFD1", "SCO1", "SCPEP1", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B3", "SFPQ", "SFSWAP", "SFXN1", "SHMT1", "SHMT2", "SIN3A", "SIRT2", "SKP1", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35B2", "SLC35F2", "SLC3A2", "SLC6A15", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMN1*", "SMYD3", "SNAP29", "SND1", "SNRNP70", "SNRPA", "SNRPA1", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SOD2", "SORT1", "SPAG9", "SPCS2", "SPCS3", "SPTLC1", "SQLE", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSU72", "STAG2", "STAT3", "STOML2", "STRBP", "STT3A", "STT3B", "STX12", "STX18", "STX7", "STX8", "STXBP3", "SUCLA2", "SUCLG2", "SUPT16H", "SUPT6H", "SURF6", "SUZ12", "SYNCRIP", "SYNGR2", "TAF15", "TAGLN2", "TAP1", "TAP2", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCE", "TCEA1", "TCERG1", "TCP1", "TDRKH", "TECR", "TFRC", "THOC1", "THOC2", "THOC3", "THOP1", "THRAP3", "TJP1", "TJP2", "TK1", "TKT", "TM9SF3", "TMED10", "TMED7", "TMED9", "TMEM97", "TMOD3", "TMPO", "TNPO1", "TOE1", "TOMM20", "TOMM40", "TOP1", "TP53", "TP53BP1", "TPI1", "TPM3", "TPP1", "TPP2", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAP1", "TRMT6", "TROVE2", "TSC2", "TSFM", "TSG101", "TSTA3", "TTK", "TTYH3", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC9", "TXNRD1", "TYMS", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2L3", "UBE4A", "UCHL5", "UGGT1", "UNC119B", "UPF1", "UQCR10", "UQCRC1", "UQCRC2", "USO1", "USP10", "USP14", "USP36", "USP39", "USP47", "USP5", "USP7", "USP8", "UTP11", "UTP14A", "UTP6", "VAMP7", "VAPA", "VAPB", "VBP1", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4B", "VRK1", "VRK3", "WARS", "WDHD1", "WDR1", "WDR33", "WDR4", "WDR82", "WIZ", "XAB2", "XPO1", "XPO4", "XPO5", "XPO7", "XRCC5", "XRCC6", "YARS", "YARS2", "YEATS2", "YEATS4", "YLPM1", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBTB10", "ZC3H15", "ZC3H7A", "ZCCHC8", "ZFR", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZNF148", "ZNF281", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ABCC4", "ACOX1", "ACP2", "ACTL6A", "ACTR1A", "AIFM1", "AK2", "ALDH1A2", "ALDH1B1", "AP3S1", "APOL2", "ASAH1", "ASNA1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5J2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "BAIAP2", "BCAS2", "CALU", "CBX1", "CBX3", "CDK2", "CHMP7", "CIRBP", "CLUH", "CNOT6", "COPZ1", "COX2", "COX5A", "COX7A2", "CPVL", "CRTAP", "CSK", "CSNK1A1", "CSTF2", "CTSA", "CYB5B", "CYB5D2", "CYP51A1", "DERL1", "DHCR24", "DHCR7", "DHFR", "DIS3", "DTYMK", "EEF1B2", "EIF3E", "EIF3J", "EIF3L", "EIF4B", "EIF4H", "EIF5", "EIF5A", "EIF6", "EPHA7", "ERAP1", "ETFA", "ETFDH", "EWSR1", "EXO1", "EXOC3", "EXOSC1", "EXOSC3", "EXOSC7", "FN3KRP", "FUS", "GAA", "GLB1", "GM2A", "GNA13", "GNAI2", "GNAI3", "HDGF", "HDGFL2", "IPO11", "KDELR1", "KDM1B", "LAMP1", "LBR", "LIMA1", "LNPEP", "LSM6", "MAPRE2", "MFN1", "MIPEP", "MPV17L2", "MTMR6", "MYL6", "NAP1L1", "NDUFS2", "NEU1", "NME1", "NPEPPS", "NRDC", "NSFL1C", "NT5C3B", "NUCB1", "NUCB2", "NUP37", "NUP62", "OCLN", "OLA1", "P3H4", "PANK4", "PARG", "PITPNA", "PITRM1", "PLBD2", "PPP2R5D", "PPT1", "PRCP", "PRDX2", "PRDX3", "PRDX6", "PRRC2B", "PSIP1", "PSPC1", "PTGES2", "PTGR1", "PXMP2", "RALA", "RAVER1", "RBM14", "RBM4", "RBMX", "RCN2", "RPF2", "S100A10", "SART1", "SCARB1", "SCARB2", "SCPEP1", "SET", "SF3A2", "SFPQ", "SLC12A2", "SLC18B1", "SLC19A1", "SLC25A10", "SLC25A11", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A32", "SLC25A33", "SLC25A4", "SLC35B2", "SLC35F2", "SLC6A15", "SNAP29", "SORT1", "SRSF1", "SRSF10", "SRSF3", "SRSF9", "SSR1", "STX8", "SYNGR2", "TAF15", "TJP2", "TM9SF3", "TMED7", "TMEM97", "TNPO1", "TOMM20", "TPT1", "TRA2B", "TRMT6", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "UNC119B", "UQCR10", "UQCRC1", "UQCRC2", "UTP6", "VAMP7", "VPS33A", "VRK3", "ZADH2", "ZMPSTE24"]} \ No newline at end of file diff --git a/pharos_protein_category/advanced/idx2term.json b/pharos_protein_category/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..c2c9a89814544d67cab453c74790749979179bf3 --- /dev/null +++ b/pharos_protein_category/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Tclin"} \ No newline at end of file diff --git a/pharos_protein_category/advanced/plot_0.png b/pharos_protein_category/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..5938e0bdee654cc6ef3383ab1db321c6706cd304 --- /dev/null +++ b/pharos_protein_category/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:df9c3a6b07c22535adcbfe98041350d2364051d45e56f98b4671da661b276eb2 +size 181585 diff --git a/pharos_protein_category/basic/idx2term.json b/pharos_protein_category/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9039799419c599c1738578378ceb9d671236c0f3 --- /dev/null +++ b/pharos_protein_category/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Tclin", "1": "Tdark", "2": "Tchem", "3": "Tbio"} \ No newline at end of file diff --git a/pharos_protein_category/basic/plot_0.png b/pharos_protein_category/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..370c4aff9765c53f65979aa3c5d2643e14141610 --- /dev/null +++ b/pharos_protein_category/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:f1dc29e59556958c729879698debdae9afb5cd4d785b148129553dead4cc3fca +size 132676 diff --git a/pharos_protein_category/basic/plot_1.png b/pharos_protein_category/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..ceac5a4da6a83aa5a69032691ab3ba2e7f4d9d2d --- /dev/null +++ b/pharos_protein_category/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:d21117cbf013ecbecb29a317583bdd9f379f60e451987546bd622a5bcf2cd966 +size 133741 diff --git a/pharos_protein_category/basic/plot_2.png b/pharos_protein_category/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..86ef34875cdf4663a58f426ee3a786c8bb8832b6 --- /dev/null +++ b/pharos_protein_category/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:6be1d6f25d8116d8d4ec9ee185ab0ca19259ff4b7dfd60bbdabc688f59433885 +size 130111 diff --git a/pharos_protein_category/basic/plot_3.png b/pharos_protein_category/basic/plot_3.png new file mode 100644 index 0000000000000000000000000000000000000000..a9b086958c4cd925f59b016ff74e7a61f33ebb5c --- /dev/null +++ b/pharos_protein_category/basic/plot_3.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:9a0846b9091063d8a41bc5937dcaa42a6af316ebee83398e87a1a98bb0d65e4c +size 144248 diff --git a/pharos_protein_category/consensus.joblib b/pharos_protein_category/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..3ba18ba4881eb1d516d5e37047ee70d47b2c2036 --- /dev/null +++ b/pharos_protein_category/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:0d1f5f932b433d2b020e3c525fd653f88e6f3b10b896f1ca10cd91b349d3f9d6 +size 54834 diff --git a/pharos_protein_category/df_merge.tsv b/pharos_protein_category/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..b0e87f2ec0561f00a8b87fc31d65dace06c13f6a --- /dev/null +++ b/pharos_protein_category/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Tclin 13 70 2.3909122744235063 0.0168065680730549 19.366504854368937 86.39077669902913 0.9399778874953114 0.4805096456956057 6.659845213621253 7.009024167820235 0.9745051203556824 0.3806460486794667 1.0 0.0877454489981553 0.0012765578089037 0.0008478274223043 0.0019621817114477 diff --git a/pharos_protein_category/metrics.json b/pharos_protein_category/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..3fbe1814ed553a3ac1d0069c50794e10780e587b --- /dev/null +++ b/pharos_protein_category/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2454, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 613.25 +} \ No newline at end of file diff --git a/pharos_protein_category/paths.json b/pharos_protein_category/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..62f775462149d0a78422e4c14d121ee342f72878 --- /dev/null +++ b/pharos_protein_category/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_protein_category/fragment/C340/C340_val_log2fc"} \ No newline at end of file diff --git a/pharos_protein_category/result.tsv b/pharos_protein_category/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..40d3776823814027f31c81afbffad765bab0b1df --- /dev/null +++ b/pharos_protein_category/result.tsv @@ -0,0 +1,5 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Tclin 0.4682737783964055 2.3909122744235063 0.0168065680730549 0.0655504169077634 0.0672262722922196 70 O75306,Q9BUF5,Q9BVA1,P49721,P20618,P06280,P07437,P00374,O43676,P48735,P10253,Q9Y375,P68371 13 +Tdark 0.3448813443135839 0.7144502385945861 0.4749488160321049 0.9240012291218092 0.6673137086894099 209 O60830,Q70UQ0,Q8WUJ1,Q9HD20,Q3SXM5,Q9H4I3,Q8WVC6,Q8N4H5,Q9NR77,P14406,Q9HD45,Q9H1E5,A0AVF1,Q9H9A5,Q8IXU6,Q69YN4,Q6ZXV5,Q8IYS2,Q5VW38,Q9NRY5,Q969T7,Q9NVE7,Q9NUQ9,L0R6Q1,Q8NFH4,Q5W0Z9,Q96IX5,Q8NC54,Q9BVG4,P62312,Q9NVZ3,Q9GZN1,Q9BWH2,Q6NT16,Q8IUX1,Q5JSZ5,Q96DE5,O75964,Q96P11,Q8N4V1,Q15629,Q69YU5,Q9UH62,Q9NUD5,Q5R3I4,Q9NPR9,Q9NSK0,Q9BXW7,Q8NBN7,O75935,Q96SY0 51 +Tchem 0.3431320613846085 0.5560047275263382 0.5782076229654154 0.968348455564744 0.6673137086894099 261 P30519,P04792,Q9H773,Q9H7Z7,P42785,Q9UIQ6,O60502,Q8WTV0,Q08752,P08183,P16278,P09601,Q15120,O15439,Q5BJF2,Q15904,P45880,Q02818,O15382,Q9UIV1,P05067,O75874,P23786,P43490,P13674,Q16850,P07099,Q13510,O60725,P48449,P55786,Q13126,P10619,Q9UBM7,Q9NZ08,P04062,Q03164,P35790 38 +Tbio 0.1573503049106292 0.4298376973270104 0.6673137086894099 0.9877499003171936 0.6673137086894099 1913 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412 diff --git a/pharos_protein_category/selections.json b/pharos_protein_category/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f6c23ecf72c14ee8e9803f0173026aa175dedc28 --- /dev/null +++ b/pharos_protein_category/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Tbio", "Tchem", "Tclin", "Tdark"], "available_proteins": ["AAAS", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABHD10", "ABHD12", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR6", "ADAM17", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC5", "ANAPC7", "ANK3", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOL2", "APOO", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG4B", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "B4GAT1", "BABAM1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCL2L12", "BCLAF1", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPTF", "BRCA1", "BRD2", "BRI3BP", "BRIX1", "BRMS1L", "BROX", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BYSL", "BZW1", "C12orf43", "C12orf73", "C15orf39", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C5orf15", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC47", "CCDC6", "CCDC86", "CCDC97", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD3EAP", "CDC123", "CDC23", "CDC27", "CDC34", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKAL1", "CEBPZ", "CECR2", "CELF1", "CENPB", "CENPI", "CEP170", "CERS2", "CFAP20", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD4", "CHERP", "CHID1", "CHKA", "CHMP3", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT10", "CNOT3", "CNOT6", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG7", "COIL", "COLGALT1", "COMMD2", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "CORO1B", "CORO1C", "COTL1", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DGCR8", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPF2", "DPH2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "ENSA", "ENY2", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERH", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120B", "FAM162A", "FAM208A", "FAM49B", "FAM8A1", "FAM98A", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FDFT1", "FDPS", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FOXK1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GIGYF2", "GINS1", "GINS4", "GLA", "GLB1", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLGB1", "GOLIM4", "GORASP2", "GOT1", "GOT2", "GPAA1", "GPATCH4", "GPD2", "GPI", "GPR107", "GPR108", "GPRASP2", "GPS1", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAUS5", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIC2", "HIF1AN", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOXA10", "HP1BP3", "HPF1", "HPRT1", "HPS6", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMPDH2", "INA", "INCENP", "INF2", "INTS11", "INTS14", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRGQ", "IRS4", "ISOC1", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JPT2", "JUP", "KARS", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIAA2013", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC2", "KLC4", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMP1", "LAMTOR1", "LAMTOR2", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDAH", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3BP", "LGMN", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L3", "LYAR", "LYPLA1", "MACF1", "MAGED2", "MAGT1", "MAK16", "MAP1B", "MAP1S", "MAP2K1", "MAP4", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARCKSL1", "MARK2", "MARS", "MAT2A", "MATR3", "MAU2", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED16", "METAP2", "METTL13", "MFN1", "MFN2", "MGEA5", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMGT1", "MMS19", "MOB4", "MOGS", "MORF4L1", "MOV10", "MPHOSPH10", "MPI", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MYBBP1A", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFAF7", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFCD", "NEMF", "NENF", "NES", "NEU1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NPTN", "NRBP1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT12", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "OAT", "OCIAD1", "OCLN", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL11", "OSBPL6", "OSBPL9", "OTUB1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIGS", "PIGT", "PIN4", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLAA", "PLBD2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1R10", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PPP6R3", "PPT1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTRH2", "PTRHD1", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RABGGTA", "RABL6", "RAC1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAD51AP1", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM34", "RBM39", "RBM4", "RBM45", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "RECQL5", "REEP5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIF1", "RINT1", "RIOK2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF114", "RNF20", "RNF40", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA3", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF8", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35A4", "SLC35B2", "SLC35F2", "SLC3A2", "SLC6A15", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX2", "SNX3", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPCS2", "SPCS3", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SQLE", "SQSTM1", "SRCAP", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "SSU72", "STAG2", "STARD3", "STAT3", "STAU1", "STAU2", "STEAP3", "STIP1", "STMN1", "STOML2", "STRAP", "STRBP", "STRN4", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TACO1", "TAF15", "TAGLN2", "TALDO1", "TAMM41", "TAP1", "TAP2", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF25", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TEX10", "TFAM", "TFG", "TFRC", "THG1L", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMMDC1", "TIPRL", "TJP1", "TJP2", "TK1", "TKT", "TLN1", "TM9SF3", "TMCO1", "TMED10", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM126B", "TMEM192", "TMEM201", "TMEM205", "TMEM214", "TMEM230", "TMEM33", "TMEM43", "TMEM65", "TMEM97", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX4", "TNKS1BP1", "TNPO1", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOX4", "TP53", "TP53BP1", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC5", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRMT6", "TRMU", "TRNT1", "TROVE2", "TSC2", "TSFM", "TSG101", "TSN", "TSPAN6", "TSR1", "TSTA3", "TTC1", "TTC19", "TTC21B", "TTC26", "TTC37", "TTC38", "TTC4", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBL5", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UCHL5", "UFC1", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF3B", "UQCR10", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USMG5", "USO1", "USP10", "USP14", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VPS13A", "VPS16", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4B", "VPS51", 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159, + "title": "Average number of proteins per term", + "value": 25.59119496855346 +} \ No newline at end of file diff --git a/protein_atlas_biological_process/paths.json b/protein_atlas_biological_process/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..04f3020bec357e91b36a2e33d67dcf0619cb2c85 --- /dev/null +++ b/protein_atlas_biological_process/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_biological_process/fragment/C340/C340_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_biological_process/result.tsv b/protein_atlas_biological_process/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..62c9376241a4133d9e97a726884de19e180637c8 --- /dev/null +++ b/protein_atlas_biological_process/result.tsv @@ -0,0 +1,51 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Electron transport 0.6323391439178526 2.8773484881076965 0.0040103244139924 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0.016926632063666 0.9337534872052672 0.117014543396648 7 P17900,Q13510,Q06136 3 +Steroid biosynthesis 0.6826010296915134 2.3323706729624942 0.0196811995394234 0.9575961079151916 0.120334674221657 15 P48449,Q15392,Q53GQ0,Q16850,Q9UBM7,Q14739 6 +Respiratory chain 0.619704333680676 2.325888930527064 0.0200244767188355 0.95989289329584 0.120334674221657 22 O75306,Q9UDW1,P31930,P00403,O43676,O14949,Q6DKK2 7 +Transport 0.4233404503903563 2.2260111586085545 0.0260134339997206 0.9848671154558511 0.1426253795157099 374 O60830,Q99595,Q08752,P21796,Q9BQE5,A6NIH7,Q9NS69,P45880,Q8IXU6,O43772,Q9BSK2,Q16134,Q9Y282,Q14849,Q9H2D1,Q13505,Q6NT16,O75964,Q8N4V1,O43169,Q15629,O43676,Q93050,P24390,Q6DKK2,Q9C0H2,Q9UDW1,O00461,Q9Y487,O43681,Q9Y619,O95197,O95721,P08183,Q8N4H5,O15439,O14949,A0AVF1,Q15904,P61421,O75306,P31930,P61020,P23786,Q99720,Q9UI26,P41440,P61916,P13804,O14925,P20290,Q9H2J7,P00403,Q9BW83,Q70HW3,Q9BUN8,P22695,P51809,P22626,Q9UBX3,Q00169,Q9BTX1,Q8TB61,Q99523,Q9HD20,Q13409,P46379,Q6NUK1,P31751,P61923,Q9H1E5,P37198,Q8NFH4,Q02978,P62820,Q99816,Q7KZ85,P84103,P18085,Q9Y5S9,Q9Y277,Q9UM00,O75431,O15118,P49069,Q92973 86 +Glyoxylate bypass 0.9824632952691674 2.2025343585866346 0.0276275848855775 0.9883751282530628 0.1464261998935612 2 P48735 1 +Translocation 0.4949328133227204 2.081804155651042 0.0373603620272275 0.9976518019773416 0.1747146341861525 43 O60830,O14925,Q99595,Q15629,Q9BTX1,P37198,Q9NS69 7 +Sterol biosynthesis 0.6861023854686222 1.995128942530908 0.0460288184519122 0.999442678756634 0.1866905971233809 11 Q9UBM7,Q16850,Q14739 3 +Lipid biosynthesis 0.4923488454881 1.9782758931220508 0.0478975911197967 0.9995919601603288 0.1866905971233809 40 P48449,Q9H7Z7,Q9UG56,Q96G23,P35790,Q16850,Q9UBM7,Q14739 8 +Cholesterol biosynthesis 0.7022719760343372 1.9754749994184144 0.0482142690163169 0.9996129820103392 0.1866905971233809 10 Q9UBM7,Q16850,Q14739 3 +Ion transport 0.476660925136922 1.8470755098197411 0.0647361973202498 0.9999760929452782 0.2287345638648827 40 P45880,P61421,O75964,P21796,Q93050,Q9Y487,Q15904,Q9C0H2 8 +Lipid metabolism 0.388695941367308 1.7574248023689856 0.0788454288404543 0.9999978675967104 0.2558453711353518 92 Q06136,Q9H7Z7,P40939,Q15392,Q14739,Q96G23,P23786,Q8NHP8,Q9H6V9,Q16850,Q13510,Q99519,P61916,P48449,Q16836,P16219,Q9UBM7,P17900,Q9UG56,P04062,Q9UHB6,Q14914,P35790 23 +Prostaglandin biosynthesis 0.8727569331158183 1.7421591513748396 0.08148059952841 0.9999986477871649 0.2591083065003439 2 Q9H7Z7 1 +Lipid transport 0.5379226400703832 1.65164786503034 0.0986063564172596 0.9999999321727668 0.2948809234587075 18 Q99720,Q14849,Q9BQE5 3 +Hypusine biosynthesis 0.829934747145188 1.5591947481961108 0.118950293491236 0.9999999982008584 0.3438744848201189 2 P49366 1 +Unfolded protein response 0.7290542620198402 1.54820230434477 0.1215735967913329 0.999999998880161 0.3451821766039632 6 Q15629,O95140,Q96CS3,Q9BUN8 4 +Prostaglandin metabolism 0.8731130150958826 1.4682826020816009 0.1420274747748648 0.9999999999735596 0.3853900481216863 3 Q14914,Q9H7Z7 2 +Tricarboxylic acid cycle 0.4769438298710057 1.315717748821179 0.1882687947439334 0.999999999999996 0.4290028645789719 20 P48735 1 +Hydrogen ion transport 0.4845741251269665 1.3084693901734887 0.1907141502393206 0.9999999999999976 0.4290028645789719 18 Q93050,Q9Y487,O75964,Q15904 4 +Cilium biogenesis/degradation 0.5033195536427623 1.2933978514891982 0.1958734928368466 0.9999999999999992 0.4290028645789719 15 A6NIH7,O95721 2 +Angiogenesis 0.5785388346066279 1.065496740144711 0.2866511999863577 1.0 0.5558236682662302 7 Q9H2J4 1 +Viral RNA replication 0.675774877650899 0.9040676495805312 0.3659595310330279 1.0 0.6324735373288201 2 Q15366 1 +RNA-mediated gene silencing 0.4156950171313399 0.7938737746996736 0.4272689183961429 1.0 0.6885406179242842 16 Q9H9A5,Q92600,Q9UIV1,Q06787,Q9ULM6 5 +Phospholipid biosynthesis 0.4764381846018087 0.7913942408605346 0.4287139696509694 1.0 0.6885406179242842 9 Q9UG56 1 +Lipid degradation 0.4653973751351729 0.778265328880671 0.4364126106004693 1.0 0.6916216909725593 10 Q8NHP8,Q9H6V9 2 +Notch signaling pathway 0.5447191104581444 0.7579297957522457 0.4484930118261849 1.0 0.6951183554935129 6 Q92542,Q9UBV2,P05067 3 +Nucleotide metabolism 0.5417625773655619 0.7455926188040614 0.4559135430863805 1.0 0.6951183554935129 6 Q969T7 1 +Phospholipid metabolism 0.4488968690483211 0.6950507522402528 0.4870234962174486 1.0 0.7120188501942236 10 P48651,P35790,Q9UG56 3 +Neurogenesis 0.3470077480104062 0.693312354681987 0.4881135513910086 1.0 0.7120188501942236 39 Q8IXJ6,Q8WUJ1,Q9BVA1,Q8WWV3,O96019,P15531,Q9Y639,Q969G3,Q96EK5 9 +Sodium transport 0.5331271002483633 0.6377315898907612 0.5236484181971881 1.0 0.7404433339395358 5 Q9H2J7 1 +Nucleotide biosynthesis 0.5351216634856583 0.5569519322871308 0.5775602711919927 1.0 0.76311075542424 4 P23919 1 +Chemotaxis 0.6164830681354596 0.5142785533540168 0.6070572539132966 1.0 0.7784040594533399 3 P26583,P09429 2 +Autophagy 0.3395259246061429 0.4600970614790091 0.6454465532111793 1.0 0.8076583864705507 24 Q8IXJ6,O95140,O95721,Q9Y4P1,P62820,Q13501 6 +ATP synthesis 0.4398234522015515 0.4534976999728821 0.650190399171261 1.0 0.8076583864705507 7 O75964,P56134 2 +Adaptive immunity 0.3608905734918045 0.4105740027371961 0.6813849297547241 1.0 0.8207591199318267 14 Q9NZ08,P10321,Q03519,P04083,Q07021 5 +Protein transport 0.3122189294934706 0.3324848204150782 0.7395231999515879 1.0 0.865555947096718 188 Q9Y3B3,O60830,O95721,Q9HD20,Q99595,P49755,Q08752,Q9Y4P1,Q6NUQ1,Q8N4H5,P61923,O60645,A0AVF1,A6NIH7,P37198,Q9NS69,Q9NR31,P61020,Q8NFH4,P62820,Q99816,Q13505,Q9UI26,Q9NVZ3,Q8NC96,O14925,P18085,O14828,P20290,Q15629,Q8N6T3,Q15388,Q9BW83,P24390,O75431,Q969Q5,Q9BUN8,Q92973,P61106,P51809,Q8WUX9,Q8NFH5,Q92572,Q9H814,Q9BTX1 45 +Symport 0.4427878977042591 0.3116240633751276 0.7553262443447022 1.0 0.865555947096718 5 Q9H2J7 1 +Phagocytosis 0.5097879282218627 0.3080940396808321 0.7580107764364683 1.0 0.865555947096718 2 P20339 1 +Inflammatory response 0.352948221127499 0.2770868794866106 0.7817133961990805 1.0 0.8729089785426362 11 Q8IV08 1 +Glucose metabolism 0.3633053146395245 0.2733295453187085 0.7845999058287951 1.0 0.8729089785426362 9 Q15120 1 +ER-Golgi transport 0.2978623218412294 0.2727191911317763 0.7850690813307986 1.0 0.8729089785426362 40 O95197,P18085,P49069,Q9Y282,P49755,P62820,P61923,Q8N6T3,P24390,Q9NR31 10 +Exocytosis 0.3334287077687331 0.1946250711092714 0.8456864744553962 1.0 0.9193028656384822 11 P11233,P51809,Q9BRK5 3 +Isoprene biosynthesis 0.4384176182708154 0.1459715327694388 0.8839438612419925 1.0 0.9468437213438272 2 P14324 1 +Antiport 0.3410768479522277 0.0738724860951361 0.941111848929728 1.0 0.997346089650491 6 P41440,P12235 2 +Peptide transport 0.376835236541598 0.0662671272616936 0.9471651543221644 1.0 0.997346089650491 2 Q03519 1 +Potassium transport 0.3338775510204038 0.0421861914335766 0.9663502704009894 1.0 1.0 4 P55011,P54709,P05026 3 diff --git a/protein_atlas_biological_process/selections.json b/protein_atlas_biological_process/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..6a977db4e98efc67b394ae02b6ca9a704e0156e7 --- /dev/null +++ b/protein_atlas_biological_process/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthesis", "Adaptive immunity", "Amino-acid biosynthesis", "Amino-acid transport", "Angiogenesis", "Antiport", "Antiviral defense", "Apoptosis", "Arginine metabolism", "Aromatic hydrocarbons catabolism", "Asparagine biosynthesis", "Autophagy", "B-cell activation", "Biological rhythms", "Biomineralization", "Branched-chain amino acid biosynthesis", "Branched-chain amino acid catabolism", "Calcium transport", "Carbohydrate metabolism", "Catecholamine metabolism", "Cell adhesion", "Cell cycle", "Cell division", "Cell shape", "Chemotaxis", "Cholesterol biosynthesis", "Cholesterol metabolism", "Chromosome partition", "Cilium biogenesis/degradation", "Coenzyme A biosynthesis", "Collagen degradation", "Complement pathway", "DNA condensation", "DNA damage", "DNA excision", "DNA recombination", "DNA repair", "DNA replication", "DNA synthesis", "Detoxification", "Differentiation", "ER-Golgi transport", "Electron transport", "Endocytosis", "Exocytosis", "Fatty acid biosynthesis", "Fatty acid metabolism", "Fertilization", "GMP biosynthesis", "GPI-anchor biosynthesis", "Galactose metabolism", "Gastrulation", "Gluconate utilization", "Gluconeogenesis", "Glucose metabolism", "Glutathione biosynthesis", "Glycogen biosynthesis", "Glycogen metabolism", "Glycolysis", "Glyoxylate bypass", "Growth arrest", "Growth regulation", "Hearing", "Heme biosynthesis", "Host-virus interaction", "Hydrogen ion transport", "Hypusine biosynthesis", "Immunity", "Inflammatory response", "Inhibition of host STAT1 by virus", "Inhibition of host STAT2 by virus", "Inhibition of host innate immune response by virus", "Inhibition of host interferon signaling pathway by virus", "Innate immunity", "Inositol biosynthesis", "Ion transport", "Iron transport", "Isoprene biosynthesis", "Leukotriene biosynthesis", "Lipid biosynthesis", "Lipid degradation", "Lipid metabolism", "Lipid transport", "Meiosis", "Methionine biosynthesis", "Methotrexate resistance", "Mitosis", "Myogenesis", "Necrosis", "Neurogenesis", "Neurotransmitter degradation", "Neurotransmitter transport", "Nonsense-mediated mRNA decay", "Notch signaling pathway", "Nucleotide biosynthesis", "Nucleotide metabolism", "One-carbon metabolism", "Oogenesis", "Osteogenesis", "Pentose shunt", "Peptide transport", "Phagocytosis", "Phenylalanine catabolism", "Phospholipid biosynthesis", "Phospholipid metabolism", "Plasminogen activation", "Polyamine biosynthesis", "Porphyrin biosynthesis", "Potassium transport", "Proline biosynthesis", "Prostaglandin biosynthesis", "Prostaglandin metabolism", "Protein biosynthesis", "Protein transport", "Purine biosynthesis", "Purine salvage", "Pyridine nucleotide biosynthesis", "Pyrimidine biosynthesis", "RNA-mediated gene silencing", "Respiratory chain", "Ribosome biogenesis", "Sensory transduction", "Serine biosynthesis", "Sodium transport", "Sodium/potassium transport", "Spermatogenesis", "Spermidine biosynthesis", "Sphingolipid metabolism", "Steroid biosynthesis", "Steroid metabolism", "Sterol biosynthesis", "Sterol metabolism", "Stress response", "Sugar transport", "Symport", "Transcription", "Transcription regulation", "Transcription termination", "Translation regulation", "Translocation", "Transport", "Tricarboxylic acid cycle", "Tyrosine catabolism", "Ubl conjugation pathway", "Unfolded protein response", "Urea cycle", "Viral RNA replication", "Viral immunoevasion", "Viral penetration into host nucleus", "Virus entry into host cell", "Vision", "Wnt signaling pathway", "Xylose metabolism", "mRNA capping", "mRNA processing", "mRNA splicing", "mRNA transport", "rRNA processing", "tRNA processing"], "available_proteins": ["AAAS", "AARS", "AARS2", "AARSD1", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABHD12", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOX1", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN4", "ACTR3", "ADAM17", "ADAR", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AKAP17A", "AKAP8L", "AKT2", "ALDH18A1", "ALDH3A2", "ALDOA", "ALDOC", "ALKBH5", "ANAPC1", "ANAPC16", "ANAPC5", "ANAPC7", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "ANXA1", "ANXA11", "ANXA2", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEX1", "API5", "APOL2", "APOO", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARG2", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL2", "ARL3", "ARL6IP1", "ARMT1", "ASAH1", "ASNA1", "ASNS", "ATAD5", "ATG4B", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "AUP1", "BABAM1", "BABAM2", "BAG6", "BANF1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCL2L12", "BCLAF1", "BIRC6", "BLM", "BMS1", "BOP1", "BPTF", "BRCA1", "BRD2", "BRIX1", "BRMS1L", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BYSL", "BZW1", "C12orf43", "C1QBP", "CACYBP", "CAD", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAPRIN1", "CARM1", "CARS", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC86", "CD2AP", "CD3EAP", "CDC123", "CDC23", "CDC27", "CDC34", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKAL1", "CEBPZ", "CELF1", "CERS2", "CFL1", "CHAF1B", "CHCHD3", "CHD4", "CHID1", "CHKA", "CHMP3", "CHMP7", "CHORDC1", "CHST14", "CHTF18", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP5", "CLASP1", "CLASP2", "CLCN3", "CLIC1", "CLINT1", "CLPTM1", "CLTC", "CMPK1", "CMTR1", "CNNM4", "CNOT1", "CNOT10", "CNOT3", "CNOT6", "CNOT7", "CNOT9", "COG7", "COMMD2", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS6", "COPS7A", "COPZ1", "COX2", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CRNKL1", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2B", "CSRP2", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CWC15", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF13", "DCAF7", "DCPS", "DCTN1", "DCTN3", "DCXR", "DDB1", "DDRGK1", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX46", "DDX47", "DDX5", "DDX51", "DDX54", "DDX56", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLST", "DNAAF5", "DNAJA3", "DNAJB1", "DNAJC2", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPF2", "DPYSL2", "DSG2", "DST", "DTYMK", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "EBNA1BP2", "ECH1", "ECHS1", "ECSIT", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "EMC4", "EMG1", "EML4", "ENO1", "ENSA", "ENY2", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERH", "ERLIN2", "ERO1A", "ERP44", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAM120B", "FAM162A", "FAM208A", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP8", "FLII", "FLNA", "FLNB", "FLOT2", "FMR1", "FOXC1", "FOXK1", "FRG1", "FTSJ3", "FUBP1", "FUBP3", "FXR1", "G3BP1", "G3BP2", "G6PD", "GADD45GIP1", "GAK", "GALK1", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GBA", "GBF1", "GCC2", "GCN1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GINS1", "GINS4", "GLE1", "GM2A", "GMPS", "GNAI2", "GNAI3", "GNL2", "GNL3L", "GNPDA1", "GOLIM4", "GORASP2", "GOT1", "GOT2", "GPAA1", "GPI", "GRB2", "GRIPAP1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSS", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP10", "GTPBP3", "GTPBP4", "GYS1", "H2AFX", "HACD3", "HADH", "HADHA", "HADHB", "HAUS5", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HELLS", "HERC2", "HIBADH", "HIBCH", "HIC2", "HIF1AN", "HINT2", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HOXA10", "HPF1", "HPRT1", "HSD17B10", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILVBL", "IMP3", "IMPDH2", "INA", "INCENP", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0391", "KIF11", "KIF23", "KIF2A", "KIF2C", "KIFBP", "KIFC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRR1", "LAMP1", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDAH", "LETM1", "LGALS3BP", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LPCAT1", "LRPPRC", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LUC7L3", "LYAR", "LYPLA1", "MACF1", "MAGT1", "MAP1S", "MAPRE1", "MAPRE2", "MARK2", "MARS", "MAT2A", "MATR3", "MAU2", "MBD3", "MBOAT7", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MDC1", "MDH1", "MDH2", "MECP2", "MED16", "MFN2", "MGEA5", "MGST2", "MIA3", "MICU1", "MID1", "MIF", "MINDY3", "MKI67", "MLEC", "MMGT1", "MMS19", "MOB4", "MORF4L1", "MOV10", "MPHOSPH10", "MRE11", "MRI1", "MRPL58", "MRPS27", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTFP1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MTX3", "MYBBP1A", "MYH10", "MYH14", "MYH9", "MYO1C", "MYO6", "NAA15", "NAMPT", "NAP1L1", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCOA5", "NCSTN", "NDC1", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA9", "NDUFAF4", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4L", "NEK9", "NELFCD", "NES", "NEU1", "NHP2", "NIP7", "NIPBL", "NISCH", "NKRF", "NLE1", "NME1", "NOC2L", "NOL11", "NOL8", "NOL9", "NONO", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPLOC4", "NPM1", "NPTN", "NSA2", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NUBP2", "NUCKS1", "NUDC", "NUDCD1", "NUDT21", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "OGDH", "OGT", "OPA1", "OPA3", "OSBP", "OSBPL11", "OSBPL6", "OSBPL9", "OTUB1", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK2", "PAK4", "PANK4", "PAPOLA", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCM1", "PCNA", "PCNP", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDK3", "PDLIM7", "PDS5A", "PDS5B", "PECR", "PELP1", "PEPD", 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"SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMU1", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX2", "SNX3", "SNX6", "SNX9", "SON", "SORT1", "SPATA5", "SPEN", "SPTLC1", "SQSTM1", "SRCAP", "SRM", "SRPK1", "SRPK2", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSBP1", "SSRP1", "SSU72", "STAG2", "STARD3", "STAT3", "STAU1", "STAU2", "STEAP3", "STMN1", "STRAP", "STRBP", "STUB1", "STX12", "STX18", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNGR2", "TACO1", "TALDO1", "TAMM41", "TAP1", "TAP2", "TARDBP", "TARS", "TARS2", "TCAF1", "TCEA1", "TCERG1", "TCF25", "TDP2", "TDRKH", "TECR", "TFAM", "TFG", "TFRC", "THG1L", "THOC1", "THOC2", "THOC3", "THOC6", "THRAP3", 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b/protein_atlas_disease_involvement/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:c912a7102c9eb5f5b5adf5c0680f62d014703cad87e3c12ebe9ce65e1e3030e8 +size 59760 diff --git a/protein_atlas_disease_involvement/df_merge.tsv b/protein_atlas_disease_involvement/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..9fb872ed4510250114f2d0bc8a08d797fb76de87 --- /dev/null +++ b/protein_atlas_disease_involvement/df_merge.tsv @@ -0,0 +1,3 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Palmoplantar keratoderma 1 6 1.984151581258469 0.0472389443504115 2.1771844660194173 6.66747572815534 -0.1081341805887323 0.4396415732659258 1.523334307555052 1.0537084013340434 1.0756885176480049 0.2789379081020651 1.0 0.083126337411673 0.1611939416425752 0.0688460117016781 0.2133837897484068 +Proto-oncogene 9 34 1.975138957043664 0.0482523809365125 10.220873786407768 42.230582524271846 0.352417122717188 0.6349839081636985 4.025676233803451 6.092151297173746 0.7870476016467428 0.3240376141995099 1.0 0.5147372580778585 0.7688112952019996 0.0278143399550537 0.054961039280446 diff --git a/protein_atlas_disease_involvement/metrics.json b/protein_atlas_disease_involvement/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..3e90258d0d69750138db10646642aafc7b449f88 --- /dev/null +++ b/protein_atlas_disease_involvement/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2454, + "annotations_size": 108, + "title": "Average number of proteins per term", + "value": 18.60185185185185 +} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/paths.json b/protein_atlas_disease_involvement/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..23d75a252e0aa7e1d311cd86240f7da3bf501abf --- /dev/null +++ b/protein_atlas_disease_involvement/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_disease_involvement/fragment/C340/C340_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/result.tsv b/protein_atlas_disease_involvement/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..e600ac12f1d09a43d1c100c479203a5326cc8e52 --- /dev/null +++ b/protein_atlas_disease_involvement/result.tsv @@ -0,0 +1,29 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Gangliosidosis 0.9021612305689062 2.0414718045786304 0.0412039536404336 0.9893724457781252 0.400865933934104 4 P16278 1 +Palmoplantar keratoderma 0.8332501859687254 1.984151581258469 0.0472389443504115 0.994626321624736 0.400865933934104 6 Q06136 1 +Proto-oncogene 0.5097330847319033 1.9751389570436635 0.0482523809365125 0.9952097928360714 0.400865933934104 34 Q01105,Q06136,Q92804,O96028,Q01844,P35637,Q03164,Q92733,Q8WY22 9 +Glutaricaciduria 0.8710602398916452 1.91747573354264 0.0551775209597575 0.997823175196891 0.4150631303234403 4 Q16134 1 +FDA approved drug targets 0.3942326373921958 1.8390843318462344 0.0659027831722129 0.9993656273753264 0.4150631303234403 93 P05067,P49721,P20618,Q16134,O75874,Q99720,P07437,P23786,P00374,Q16836,Q16850,P48735,P10253,P68371 14 +Hirschsprung disease 0.8837683523654174 1.7889781341650728 0.0736183370762906 0.9997409911577432 0.4150631303234403 2 Q96EK5 1 +Niemann-Pick disease 0.8560358890701447 1.6708660147794148 0.0947481456292553 0.999978566272873 0.4158535386438242 2 P61916 1 +Amyotrophic lateral sclerosis 0.6012996425744306 1.6563292342388682 0.0976551633250686 0.9999848562280846 0.4158535386438242 12 P35637,P07737,Q13501 3 +Neuronal ceroid lipofuscinosis 0.91861693778639 1.6443065892976931 0.1001128889327724 0.9999887200440004 0.4158535386438242 3 P50897 1 +Mucopolysaccharidosis 0.7386688444262863 1.4974553154027674 0.1342748243091553 0.9999998273982892 0.4604885464306867 5 P15586,P54802,P16278,P08236 4 +Craniosynostosis 0.7871125611745508 1.3754549112075116 0.1689904551730949 0.9999999979229388 0.513695705315191 2 P07237 1 +Primary mitochondrial disease 0.3725467056296325 1.357796720532591 0.1745281958428959 0.9999999989911136 0.513695705315191 70 Q9Y2R0,O75880,O14949,Q9Y375,O75306,Q8NFF5,Q16795,Q96IX5,Q8IUX1,P00403,P20674,O95831,O43676,P12235,Q00059,Q6DKK2,Q70HW3,Q9NPL8,P22695,Q5XKP0,Q07021,Q9H0R6,Q9P032,Q9UBX3,Q8N183,Q99797 26 +Ichthyosis 0.587381152145044 1.2920327039076207 0.1963458191674152 0.999999999944092 0.5301337117520212 8 Q15738,P04062,P18074,O95721 4 +Deafness 0.3679267762394819 0.9416332986245158 0.3463804154240586 1.0 0.6680193726035416 43 Q9NR28,Q9UG56,Q16740,P18074,O95831,Q15067,Q9NWM8,P68371 8 +Williams-Beuren syndrome 0.538784997902105 0.8837710715245001 0.3768198055318141 1.0 0.6782756499572654 7 Q15056,Q9Y4P3,P35250 3 +Parkinson disease 0.5242910291173419 0.8181705966241587 0.4132597821609387 1.0 0.700588285236164 7 P04062 1 +Neurodegeneration 0.3073123005756287 0.8148408262112978 0.4151634282880971 1.0 0.700588285236164 107 P04792,P50897,Q15120,Q13501,Q8IXJ6,P07737,P05067,Q8IV08,O43464,O75503,Q13510,Q99720,Q8N0X7,Q14108,Q15041,O95831,O95140,Q96GM8,P04062,P35637 20 +Parkinsonism 0.4685309106004549 0.7139186913343464 0.4752774586948507 1.0 0.7548524343977041 8 P04062 1 +Osteogenesis imperfecta 0.4615094278705928 0.5430282134752515 0.5871103771360457 1.0 0.8676945228159169 7 O75718,Q96AY3,P07237 3 +Ehlers-Danlos syndrome 0.5430785678796906 0.2982670843086208 0.765499324471554 1.0 0.9788399326706152 3 Q9NWM8 1 +Emery-Dreifuss muscular dystrophy 0.4287464271131057 0.2682460303229599 0.78850994576244 1.0 0.9788399326706152 5 Q13642,Q9BTV4,Q8WXH0,P50402 4 +Holoprosencephaly 0.4738988580750411 0.2172144487003709 0.8280412250553681 1.0 1.0 2 A5YKK6 1 +Epidermolysis bullosa 0.4834761321909531 0.1643356270851449 0.869466936573621 1.0 1.0 3 P15924,Q03001 2 +Cataract 0.2996252660115405 0.1579584183681923 0.8744895646193573 1.0 1.0 21 P48449,Q9UG56 2 +Dwarfism 0.2781267340427655 0.1055442525698696 0.915943957580032 1.0 1.0 37 O75718,O95831,Q9UG56,Q14739 4 +Cushing syndrome 0.3698324942542174 0.0931041346707471 0.9258208327141908 1.0 1.0 4 P17612,P10644 2 +Charcot-Marie-Tooth disease 0.2876040119988606 0.0804174467454115 0.9359052513466266 1.0 1.0 19 O95140,P04792,O95831,Q15120 4 +Disease variant 0.2435361036404217 0.0176246546895181 0.985938288132154 1.0 1.0 636 Q9UHX1,Q06136,Q16740,P50897,P16278,P48735,Q14739,O43772,Q16134,P07437,Q8WWV3,Q9H2D1,O75503,Q13510,P68371,Q14108,Q9BUF5,P48449,Q9BVA1,O75844,P00374,P10619,Q16836,O95831,O43676,Q9UBM7,P17900,O15460,Q9UG56,P04062,P35270,P35637,O14979,P10253,Q99797,Q9Y619,P28070,Q9NR28,P04792,P06280,Q86XL3,P40939,Q15120,O14949,Q15392,Q15904,Q9Y375,Q13501,O75306,O15382,P07737,P05067,Q8IV08,P23786,Q99720,Q99519,P61916,P13804,O00584,O75718,P18074,P00403,P16219,P20674,Q15067,Q9BW83,Q70HW3,Q96GM8,P22695,P22626,Q14738,O75648,Q9H0R6,Q9UBX3,Q01105,Q13409,P07237,Q6NUK1,P31751,P31483,P37198,P42892,Q6ZXV5,Q8NFF5,Q8NFH4,O43464,Q02978,O60701 88 diff --git a/protein_atlas_disease_involvement/selections.json b/protein_atlas_disease_involvement/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..5caa371b9924d7269b2bb055bf723d7b78ee3815 --- /dev/null +++ b/protein_atlas_disease_involvement/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Aicardi-Goutieres syndrome", "Albinism", "Allergen", "Alport syndrome", "Alzheimer disease", "Amelogenesis imperfecta", "Amyloidosis", "Amyotrophic lateral sclerosis", "Atrial fibrillation", "Autism", "Autism spectrum disorder", "Bardet-Biedl syndrome", "Bartter syndrome", "Cancer-related genes", "Cardiomyopathy", "Cataract", "Charcot-Marie-Tooth disease", "Ciliopathy", "Cockayne syndrome", "Cone-rod dystrophy", "Congenital adrenal hyperplasia", "Congenital disorder of glycosylation", "Congenital hypothyroidism", "Congenital muscular dystrophy", "Congenital myasthenic syndrome", "Craniosynostosis", "Cushing syndrome", "Deafness", "Diabetes insipidus", "Diabetes mellitus", "Diamond-Blackfan anemia", "Disease variant", "Dwarfism", "Dyskeratosis congenita", "Dystonia", "Dystroglycanopathy", "Ectodermal dysplasia", "Ehlers-Danlos syndrome", "Elliptocytosis", "Emery-Dreifuss muscular dystrophy", "Epidermolysis bullosa", "Epilepsy", "FDA approved drug targets", "Fanconi anemia", "Gangliosidosis", "Gaucher disease", "Glaucoma", "Glutaricaciduria", "Glycogen storage disease", "Gout", "Hereditary hemolytic anemia", "Hereditary nonpolyposis colorectal cancer", "Hereditary spastic paraplegia", "Hermansky-Pudlak syndrome", "Hirschsprung disease", "Holoprosencephaly", "Hypogonadotropic hypogonadism", "Hypotrichosis", "Ichthyosis", "Intrahepatic cholestasis", "Joubert syndrome", "Kallmann syndrome", "Kartagener syndrome", "Leber congenital amaurosis", "Leigh syndrome", "Leukodystrophy", "Li-Fraumeni syndrome", "Limb-girdle muscular dystrophy", "Lissencephaly", "Meckel syndrome", "Mental retardation", "Microphthalmia", "Mucopolysaccharidosis", "Myofibrillar myopathy", "Nemaline myopathy", "Nephronophthisis", "Neurodegeneration", "Neuronal ceroid lipofuscinosis", "Neuropathy", "Niemann-Pick disease", "Non-syndromic deafness", "Obesity", "Oncogene", "Osteogenesis imperfecta", "Palmoplantar keratoderma", "Parkinson disease", "Parkinsonism", "Peroxisome biogenesis disorder", "Peters anomaly", "Pontocerebellar hypoplasia", "Premature ovarian failure", "Primary ciliary dyskinesia", "Primary hypomagnesemia", "Primary microcephaly", "Primary mitochondrial disease", "Progressive external ophthalmoplegia", "Proto-oncogene", "Pyropoikilocytosis", "Retinitis pigmentosa", "Rhizomelic chondrodysplasia punctata", "SCID", "Schizophrenia", "Spinocerebellar ataxia", "Systemic lupus erythematosus", "Tumor suppressor", "Williams-Beuren syndrome", "Xeroderma pigmentosum", "Zellweger syndrome"], "available_proteins": ["AAAS", "AARS", "AARS2", "ABCB1", "ABCB7", "ABHD12", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACLY", "ACO1", "ACO2", "ACOX1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ADAR", "ADD3", "ADK", "ADNP", "ADPRHL2", "ADSL", "AFDN", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP12", "AKAP13", "AKR1B1", "AKT2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ANAPC1", "ANK3", "ANKLE2", "ANLN", "ANXA1", "ANXA11", "ANXA2", "ANXA7", "AP1B1", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "APEX1", "APOL2", "APP", "APRT", "ARCN1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARL2", "ARL3", "ARL6IP1", "ARPC1B", "ASAH1", "ASNS", "ASPH", "ATAD1", "ATAD3A", "ATIC", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP6AP1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATXN10", "B4GAT1", "BANF1", "BAZ1B", "BCAP31", "BCAT2", "BCLAF1", "BIRC6", "BLM", "BLMH", "BMS1", "BPTF", "BRCA1", "BRI3BP", "BUB1B", "BUD23", "C19orf70", "C1QBP", "CAD", "CALR", "CAMK2G", "CAMLG", "CANX", "CAPN1", "CARM1", "CARS", "CAST", "CCAR1", "CCAR2", "CCDC47", "CCDC6", "CCT5", "CDC27", "CDC34", "CDC37", "CDC42", "CDC73", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CFL2", "CHAMP1", "CHD4", "CHST14", "CISD2", "CIZ1", "CKB", "CKMT1A*", "CLIC1", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNNM4", "CNOT1", "CNOT3", "COA3", "COA7", "COG7", "COLGALT1", "COMT", "COPA", "COPB2", "COX2", "COX4I1", "COX5A", "CPOX", "CPSF1", "CPT2", "CRTAP", "CSDE1", "CSE1L", "CSNK2B", "CSTB", "CTBP1", "CTNNB1", "CTNNBL1", "CTNND1", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWF19L1", "CYB5R3", "CYC1", "CYP51A1", "DAD1", "DARS", "DARS2", "DBN1", "DCPS", "DCTN1", "DDOST", "DDRGK1", "DDX10", "DDX3X", "DDX41", "DDX5", "DDX6", "DEK", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHX16", "DHX30", "DHX37", "DHX38", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DIS3", "DKC1", "DLD", "DLST", "DNAAF5", "DNAJB1", "DNAJC2", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPF2", "DPM1", "DSG2", "DSP", "DST", "DYNC1H1", "DYNC1I2", "DYNLL1", "ECE1", "ECHS1", "EDC3", "EEF1A2", "EEF2", "EFL1", "EFTUD2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S2", "EIF3E", "EIF3F", "EIF3H", "EIF4A2", "EIF4A3", "EIF4E", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELP1", "ELP2", "EMC1", "EMD", "EMG1", "EML4", "ENO1", "EPB41", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERC1", "ERCC2", "ERCC3", "ERLIN2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXOSC3", "EZR", "FADS2", "FAF1", "FAH", "FANCI", "FAR1", "FARSB", "FASN", "FDPS", "FECH", "FEN1", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKBP5", "FKBP8", "FLAD1", "FLNA", "FLNB", "FLNC", "FMR1", "FNTB", "FOXC1", "FSCN1", "FTO", "FUBP1", "FUS", "G6PD", "GAA", "GALK1", "GALNT2", "GANAB", "GAPDH", "GARS", "GART", "GATB", "GBA", "GCDH", "GDI1", "GEMIN4", "GFM1", "GFPT1", "GGCX", "GIGYF2", "GINS1", "GLA", "GLB1", "GLDC", "GLE1", "GLMN", "GLO1", "GLRX5", "GLS", "GLUD1", "GM2A", "GMPPA", "GMPS", "GNA13", "GNAI3", "GNPAT", "GNS", "GOT1", "GOT2", "GPAA1", "GPI", "GPRASP2", "GRB2", "GSK3A", "GSK3B", "GSR", "GSS", "GSTM3", "GSTZ1", "GTF2I", "GTPBP3", "GUSB", "GYS1", "H4C1*", "HADH", "HADHA", "HADHB", "HAX1", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HELLS", "HERC2", "HEXA", "HEXB", "HIBCH", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLCS", "HMGA1", "HMGB3", "HMGCL", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HPRT1", "HPS6", "HSD17B10", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFT27", "IGBP1", "IGF2R", "ILF3", "ILK", "IMPDH2", "INF2", "IPO7", "IRS4", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KDM1A", "KDM3B", "KDSR", "KEAP1", "KIF11", "KIF14", "KIF22", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KLC2", "KMT2A", "KTN1", "L2HGDH", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LEMD3", "LGALS3BP", "LGMN", "LIPA", "LMNA", "LMNB1", "LMNB2", "LONP1", "LRBA", "LRPPRC", "LSS", "LTA4H", "MACF1", "MAGED2", "MAGT1", "MAP1B", "MAP2K1", "MAP4", "MARS", "MATR3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM5", "MCM7", "MCTS1", "MDC1", "MDH1", "MDH2", "MECP2", "MFN2", "MICU1", "MID1", "MIF", "MINPP1", "MIPEP", "MKI67", "MMAB", "MOGS", "MPI", "MRE11", "MRPL12", "MRPL3", "MRPL44", "MRPS2", "MRPS22", "MRPS23", "MRPS34", "MRPS7", "MSH2", "MSH6", "MSI2", "MSN", "MTA1", "MTOR", "MTPAP", "MTR", "MYH10", "MYH14", "MYH9", "MYO6", "NAA15", "NAGLU", "NAMPT", "NANS", "NAXE", "NCAPD2", "NCAPH", "NCSTN", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFB11", "NDUFB3", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NEDD4L", "NEFL", "NEK9", "NEU1", "NHLRC2", "NHP2", "NIPBL", "NISCH", "NME1", "NNT", "NONO", "NOP56", "NPC1", "NPC2", "NPM1", "NSD2", "NSDHL", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NUCB2", "NUDT1", "NUMA1", "NUP107", "NUP133", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP37", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "OAT", "OCLN", "OGDH", "OGT", "OPA1", "OPA3", "P3H1", "P4HA2", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PARK7", "PARN", "PARP1", "PARP2", "PBRM1", "PC", "PCBP1", "PCCA", "PCCB", "PCM1", "PCNA", "PDCD4", "PDHA1", "PDHB", "PDK3", "PEPD", "PEX14", "PFKM", "PFN1", "PGK1", "PGM1", "PGM3", "PHB", "PHF6", "PHGDH", "PHIP", "PICALM", "PIGS", "PIGT", "PISD", "PKM", "PLAA", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNN", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLD1", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR3A", "POP1", "POR", "PPA2", "PPIB", "PPIF", "PPP2R1A", "PPP2R5D", "PPP5C", "PPT1", "PQBP1", "PRC1", "PRCC", "PRDX2", "PRDX4", "PRDX5", "PREPL", "PRKACA", "PRKAR1A", "PRKCSH", "PRKDC", "PRPF3", "PRPF31", "PRPF4", "PRPF6", "PRPF8", "PSAT1", "PSIP1", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMD12", "PSMD4", "PTDSS1", "PTRH2", "PUF60", "PURA", "PUS1", "PUS7", "PYCR1", "PYCR2", "PYGL", "QARS", "QKI", "QRSL1", "RAB10", "RAB18", "RAB3GAP2", "RAB7A", "RAB8A", "RAC1", "RAD21", "RAD23B", "RANBP2", "RANBP3", "RARS", "RARS2", "RBM10", "RBM12", "RBM15", "RBM28", "RBMX", "RDH11", "RDX", "REPS1", "RFC1", "RFC2", "RHOA", "RINT1", "RIPK1", "RNASEH2A", "RNASET2", "ROCK2", "RP2", "RPL10", "RPL11", "RPL13", "RPL15", "RPL18", "RPL21", "RPL22", "RPL27", "RPL3", "RPL35", "RPL35A", "RPL5", "RPN1", "RPS10", "RPS15", "RPS15A", "RPS17", "RPS19", "RPS2", "RPS23", "RPS24", "RPS28", "RPS3", "RPS6KA1", "RPS6KA3", "RPS7", "RPSA", "RRM1", "RRM2", "RTN4IP1", "SAMHD1", "SARS", "SART1", "SBDS", "SCARB2", "SCO1", "SCRIB", "SDHA", "SDHB", "SEC23A", "SEC31A", "SEC61A1", "SEC63", "SEPT2", "SEPT9", "SERPINB6", "SERPINH1", "SET", "SF3B1", "SFPQ", "SGPL1", "SH3GL1", "SHOC2", "SIGMAR1", "SIN3A", "SIRT2", "SKIV2L", "SKP2", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC3A2", "SLC9A3R1", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC3", "SMCHD1", "SMN1*", "SMPD4", "SMYD3", "SNAP29", "SND1", "SNRNP200", "SNRPE", "SNX3", "SOD2", "SON", "SPART", "SPATA5", "SPEN", "SPR", "SPTAN1", "SPTLC1", "SQLE", "SQSTM1", "SRP54", "SRP72", "SRSF2", "SRSF3", "SSB", "SSR4", "STAG2", "STARD3", "STAT3", "STMN1", "STRAP", "STT3A", "STT3B", "STUB1", "SUCLA2", "SUCLG1", "SUZ12", "SYNE2", "TACO1", "TAF15", "TALDO1", "TAP1", "TARDBP", "TARS", "TARS2", "TBC1D4", "TBCE", "TBL2", "TCEA1", "TCOF1", "TDP2", "TECR", "TELO2", "TFAM", "TFG", "TFRC", "THG1L", "THOC2", "THOC6", "TIA1", "TIMM17A", "TIMM50", "TIMMDC1", "TJP2", "TK1", "TKT", "TMCO1", "TMEM126B", "TMEM230", "TMEM43", "TMTC3", "TMX2", "TOE1", "TOM1", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TP53", "TP53BP1", "TPD52", "TPI1", "TPM3", "TPP1", "TPR", "TPX2", "TRAPPC11", "TRIM25", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRMU", "TRNT1", "TSC2", "TSFM", "TSG101", "TTC19", "TTC21B", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "TWF1", "TXLNA", "TXNRD1", "TYMS", "UBA1", "UBE2N", "UBQLN4", "UBR5", "UBTF", "UFC1", "UGDH", "UGP2", "UMPS", "UNG", "UPF3B", "UQCRC2", "UQCRQ", "UROD", "USMG5", "USP8", "USP9X", "UTP4", "VAPB", "VARS1", "VARS2", "VCL", "VCP", "VIM", "VPS13A", "VPS16", "VPS33A", "VPS33B", "VPS35", "VPS51", "VPS53", "VRK1", "WARS", "WDR1", "WDR11", "WDR36", "WDR4", "WDR45B", "WDR5", "WFS1", "WRAP53", "XPO1", "XRCC1", "XRCC5", "XRCC6", "YARS", "YARS2", "YBX1", "YEATS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAZ", "ZC3H14", "ZCCHC8", "ZMPSTE24", "ZMYM2", "ZNF148"], "leading_proteins": ["ACADS", "ACOX1", "AIFM1", "AKT2", "ANKLE2", "APP", "ARL6IP1", "ASAH1", "ATP6AP1", "BCAT2", "BRI3BP", "C19orf70", "C1QBP", "CLN5", "CLPP", "CNOT1", "COA3", "COX2", "COX5A", "CPT2", "CRTAP", "CTSA", "CYP51A1", "DHCR24", "DHCR7", "DHFR", "DIABLO", "DSP", "DST", "DYNC1I2", "ECE1", "EIF4H", "EMD", "ERCC2", "ETFA", "ETFDH", "EWSR1", "FHL1", "FKBP10", "FKBP14", "FLAD1", "FUS", "GAA", "GBA", "GLA", "GLB1", "GM2A", "GNS", "GUSB", "HADH", "HADHA", "HNRNPA2B1", "HNRNPDL", "HSPB1", "HTRA2", "IDH1", "IDH2", "IFT27", "KDSR", "KIFBP", "KMT2A", "LBR", "LSS", "MFN2", "MIPEP", "NAGLU", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFB3", "NDUFS2", "NEU1", "NPC2", "NSD2", "NSDHL", "NUP37", "NUP62", "P4HA2", "P4HB", "PDK3", "PFN1", "PISD", 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a/protein_atlas_molecular_function/df_merge.tsv b/protein_atlas_molecular_function/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..d2be68c5d0e426bd4592234a05e07b7aa122599c --- /dev/null +++ b/protein_atlas_molecular_function/df_merge.tsv @@ -0,0 +1,8 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Receptor 10 30 3.1188266393152184 0.00181572759707 13.475728155339803 38.71116504854369 1.6655960679271569 0.1791616261110447 5.431559450288914 6.105192092581698 1.9169648296245776 0.2753083483896962 1.0 0.1182182962859897 0.0958446637688343 0.398863617748935 0.5443329692412255 +Protease 11 71 2.86416084978717 0.0041811563279086 20.788834951456312 82.44417475728156 1.1215350835872162 0.3507517256058336 6.07090559629836 8.079357013764625 1.4678877461728397 0.3691345771929886 1.0 0.0047545290563285 1.333514718851362e-05 0.0098791033393096 0.0035372186578423 +Glycosidase 6 15 2.762099767801751 0.0057430926234587 7.798543689320389 18.135922330097088 0.5112745472223946 0.1951515073440806 2.9064203812520417 1.9684331341643595 1.9501681029822375 0.2619382904734375 1.0 0.187449079081247 0.3432341150980792 6.706147432458563e-05 0.0008799913632697 +Oxidoreductase 27 143 2.43968200387726 0.0147001956041372 36.64563106796116 165.7621359223301 0.5091071251362119 0.5527126631147542 14.160338956360992 12.210799107974529 1.1772957028589783 0.3900527505954884 0.067668691199019 0.00023880690681 2.317687312937369e-07 2.3494296994086288e-08 3.6156545047771846e-08 +Host cell receptor for virus entry 3 14 2.1937290984179967 0.0282548906261759 4.509708737864078 15.157766990291265 0.7214109752050332 0.2527966464979699 2.499010078306418 1.9009100692398744 1.5211756979359785 0.2791170769282048 1.0 0.1835089509173778 0.0625314301217693 0.0801176308941427 0.1413381011359915 +Carboxypeptidase 3 6 2.128077910853737 0.0333306244216842 3.1359223300970873 6.150485436893204 0.9957728306848488 0.1212034427500092 1.2071674596015187 0.4479454254223922 1.8250051834990677 0.2074401112551974 1.0 4.557535944516599e-05 1.0516191954151127e-05 0.000366006536683 0.0047081007231922 +Metalloprotease 7 25 2.085090819044658 0.0370610574829399 8.160194174757281 26.429611650485437 1.390302281711237 0.2661274848815638 3.192614043118206 1.543038499308978 1.1108461579919544 0.309446154241223 1.0 0.2443632781182481 0.0002377020434721 0.0026306375243077 0.0016516323552223 diff --git a/protein_atlas_molecular_function/metrics.json b/protein_atlas_molecular_function/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..eb8f2fd80ced8bb8d2e18b36e319cdcc3b5b6dc0 --- /dev/null +++ b/protein_atlas_molecular_function/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2454, + "annotations_size": 93, + "title": "Average number of proteins per term", + "value": 32.81720430107527 +} \ No newline at end of file diff --git a/protein_atlas_molecular_function/paths.json b/protein_atlas_molecular_function/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..88a177364c66e4c09a70ec7ddd0b7c684f5dea9f --- /dev/null +++ b/protein_atlas_molecular_function/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_molecular_function/fragment/C340/C340_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_molecular_function/result.tsv b/protein_atlas_molecular_function/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..4517a3bce583ffb261616accfb917379455e023f --- /dev/null +++ b/protein_atlas_molecular_function/result.tsv @@ -0,0 +1,28 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Receptor 0.6934869701085401 3.1188266393152184 0.00181572759707 0.1555047409427608 0.0663211896078182 30 Q14108,P11279,Q99523,Q8WTV0,O15173,Q9Y2I1,P24390,Q99720,Q9NS69,Q14739 10 +Protease 0.5145731301586265 2.86416084978717 0.0041811563279086 0.3227147344944211 0.0664425405238946 71 Q9NZ08,Q9HB40,P28072,P55786,P42785,Q16740,Q9UIQ6,O43847,O75844,P10619,Q9H3G5 11 +Glycosidase 0.7632994790512263 2.762099767801751 0.0057430926234587 0.4147096477909081 0.0745510404772043 15 P06280,P04062,O60502,Q9BTY2,P16278,P10253 6 +Oxidoreductase 0.4501750842765466 2.43968200387726 0.0147001956041372 0.747732745165063 0.1008769139415104 143 P30519,Q06136,O14880,P40939,P09601,P48735,Q15392,Q14739,O75306,Q8N4Q0,Q16134,O75874,P13674,Q8NBX0,Q16850,Q9UHG3,P30837,P00374,Q16836,P16219,O95831,Q9UBM7,O15460,O94788,P35270,Q14914,Q8NB78 27 +Host cell receptor for virus entry 0.6693930582134588 2.1937290984179967 0.0282548906261759 0.9304383599352776 0.131385241411718 14 Q14108,P11279,Q8WTV0 3 +Carboxypeptidase 0.868626133702689 2.128077910853737 0.0333306244216842 0.9572584468484594 0.140897639600756 6 P42785,Q9HB40,Q9H3G5 3 +Metalloprotease 0.5600963497556782 2.085090819044658 0.0370610574829399 0.9701679020312244 0.1498555802571051 25 Q9NZ08,P55786,O43847,Q9UIQ6,O75844,Q5JRX3,Q99797 7 +Porin 0.8668971632003581 1.9007729842365364 0.0573317541155944 0.9958754587574294 0.2221605471979284 4 P21796 1 +Monooxygenase 0.8299347471451757 1.5591947481960584 0.1189502934912485 0.9999923257099448 0.3671127921138724 2 Q16850 1 +Aminopeptidase 0.598222984804594 1.5448980273049489 0.1223709307046241 0.9999946553044006 0.3671127921138724 11 Q9UIQ6,P55786 2 +Threonine protease 0.872297021623831 1.4651180605013994 0.1428887100116065 0.9999994078100092 0.4101732351147143 3 Q99436,P28072 2 +Rotamase 0.4789908901426788 1.2996796540081244 0.1937107865176526 0.9999999979879024 0.4740816617405708 19 Q9Y680,Q08752 2 +Guanine-nucleotide releasing factor 0.5548181984124485 1.1835557304652515 0.2365889732705786 0.9999999999875108 0.5238755836705669 9 P80303 1 +Exonuclease 0.4295767992738425 0.9466901640136844 0.3437966839875663 1.0 0.5871731865878215 18 Q8IV08,Q9UQ84,Q9UIV1 3 +Ion channel 0.6204566209081588 0.8889102679294526 0.3740513066709909 1.0 0.5997719227655545 4 Q9C0H2 1 +Glycosyltransferase 0.3684477959645241 0.6953046611424603 0.486864393792962 1.0 0.7015304004615374 25 P43490,Q13126 2 +Translocase 0.3739932037123354 0.6359605871577104 0.524802111081778 1.0 0.7177440636853728 21 O15439,P00403,O75306,P08183 4 +Muscle protein 0.5330593899363386 0.5493983398383618 0.5827321131489778 1.0 0.7630358206408838 4 P60660 1 +Endonuclease 0.3835697025330791 0.5374740710044436 0.5909401907195635 1.0 0.7630358206408838 14 O00584,Q9UQ84 2 +Transducer 0.4948204028119967 0.4911919604385587 0.6232906846059478 1.0 0.7630358206408838 5 P04899 1 +Growth factor 0.5681076672104434 0.4908166192634401 0.6235561545022277 1.0 0.7630358206408838 2 P51858 1 +Nuclease 0.33186123682519 0.4629652292871163 0.6433892905167915 1.0 0.7671180002315591 30 Q8IV08,O00584,Q9UQ84,Q9UIV1 4 +Repressor 0.2831069417438692 0.4097732533950441 0.6819722882685604 1.0 0.8028281368224824 92 Q13242,Q14011,Q9UHX1,Q92600,Q8WXF1,Q01844,O00267,Q96JB3,Q9BQ70,Q9UIV1,Q8IXH7,Q9UIF9,Q13217,P62995,P38159,Q9NX63,Q13363,P23246,Q5PSV4,Q13185,Q15233,P85037,P26368,P61978,Q9UQR1,Q8NB78,Q06787,O14979,Q96PK6 29 +Methyltransferase 0.319645518866841 0.3618529642463088 0.7174619104604594 1.0 0.834049470910284 29 Q9BV86,O60725 2 +Chaperone 0.2652475190407387 0.1614328709123383 0.8717524789416333 1.0 0.9277170223055284 88 Q01105,P04792,Q8WXX5,O75347,P46379,Q08752,P07237,O75880,Q9Y375,Q99471,Q9H2J4,Q13217,Q15785,Q7KZ85,Q15185,O60884,Q8IUX1,Q9Y5J9,O75937,Q9BS26,P20290,P61758,Q92688,Q99543,O75832,Q9NPL8,O95456,Q8N183 28 +Hydrolase 0.312294592589548 0.0468196992952876 0.9626569284821258 1.0 0.9947454927648632 310 Q9HB40,Q9H773,P42785,Q16740,Q9UIQ6,P06280,O60502,P50897,P16278,Q9H3G5,Q9UIV1,Q969T7,P61020,Q8IV08,O00148,Q15165,Q8NHP8,Q9H6V9,Q9BTY2,P07099,P11233,Q13510,Q9UQ84,Q99519,Q8IWA4,O00584,P28072,P55786,O43847,O75844,Q9NTK5,P10619,Q9NUJ1,Q9NZ08,P17900,P04062,P11117,P10253,O43681,Q99797 40 +Dioxygenase 0.2760775376829121 0.0131245245791385 0.9895284450976688 1.0 1.0 15 O15460 1 diff --git a/protein_atlas_molecular_function/selections.json b/protein_atlas_molecular_function/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..0bc55b97b89496b578174e2ff67fb9b32fcacedc --- /dev/null +++ b/protein_atlas_molecular_function/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin capping", "Actin-binding", "Activator", "Acyltransferase", "Allosteric enzyme", "Aminoacyl-tRNA synthetase", "Aminopeptidase", "Aminotransferase", "Antibiotic", "Antimicrobial", "Antioxidant", "Aspartyl protease", "Blood group antigen", "Calcium channel", "Calmodulin-binding", "Carboxypeptidase", "Chaperone", "Chloride channel", "Chromatin regulator", "Cytokine", "DNA-binding", "DNA-directed DNA polymerase", "Decarboxylase", "Developmental protein", "Dioxygenase", "Dipeptidase", "Elongation factor", "Endonuclease", "Excision nuclease", "Exonuclease", "Fungicide", "GTPase activation", "Glycosidase", "Glycosyltransferase", "Growth factor", "Guanine-nucleotide releasing factor", "Helicase", "Heparin-binding", "Hormone", "Host cell receptor for virus entry", "Hydrolase", "Initiation factor", "Integrin", "Ion channel", "Isomerase", "Kinase", "Ligase", "Lyase", "Metalloenzyme inhibitor", "Metalloprotease", "Methyltransferase", "Mitogen", "Monooxygenase", "Motor protein", "Multifunctional enzyme", "Muscle protein", "Myosin", "Nuclease", "Nucleotidyltransferase", "Oxidoreductase", "Peroxidase", "Phospholipase A2 inhibitor", "Porin", "Prenyltransferase", "Protease", "Protease inhibitor", "Protein phosphatase", "Protein phosphatase inhibitor", "Protein synthesis inhibitor", "RNA-binding", "Receptor", "Repressor", "Ribonucleoprotein", "Ribosomal protein", "Rotamase", "Serine esterase", "Serine protease", "Serine protease inhibitor", "Serine/threonine-protein kinase", "Signal transduction inhibitor", "Thiol protease", "Thiol protease inhibitor", "Threonine protease", "Topoisomerase", "Transducer", "Transferase", "Translational shunt", "Translocase", "Tumor antigen", "Tyrosine-protein kinase", "Voltage-gated channel", "rRNA-binding", "tRNA-binding"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCC4", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR2", "ACTR3", "ADAM17", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "ANKHD1", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA2", "APEH", "APEX1", "APLP2", "APP", "APRT", "ARFGAP1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARMT1", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATG4B", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5B", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "B4GAT1", "BABAM1", "BABAM2", "BAG6", "BANF1", "BAZ1B", "BAZ2A", "BCAT2", "BCLAF1", "BIRC6", "BLM", "BLMH", "BLVRA", "BPTF", "BRCA1", "BRD2", "BRMS1L", "BSG", "BTF3", "BUB1B", "BUD23", "BZW1", "C12orf43", "CAD", "CALD1", "CALR", "CAMK2D", "CAMK2G", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBR1", "CBX3", "CCAR1", "CCAR2", "CCDC47", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC34", "CDC37", "CDC42", "CDC5L", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK6", "CDKAL1", "CEBPZ", "CECR2", "CELF1", "CENPB", "CERS2", "CFL1", "CFL2", "CHCHD3", "CHD4", "CHKA", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIRBP", "CKB", "CKMT1A*", "CLGN", "CLIC1", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT3", "CNOT6", "CNOT7", "CNOT9", "CNP", "COLGALT1", "COMT", "COPA", "COPS5", "CORO1B", "CORO1C", "COTL1", "COX2", "COX4I1", "CPD", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRYZ", "CS", "CSDE1", "CSK", "CSNK1A1", "CSRP2", "CSTB", "CSTF2", "CTBP1", "CTBP2", "CTDSPL2", "CTNNB1", "CTPS1", "CTPS2", "CTSA", "CUL5", "CXorf57", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF13", "DCAF7", "DCD", "DCPS", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DGCR8", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIAPH1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK7", "DOHH", "DPF2", "DPH2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DRG1", "DRG2", "DST", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "ECE1", "ECH1", "ECHS1", "ECI2", "EDC3", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EFL1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "EMD", "EMG1", "ENAH", "ENO1", "ENSA", "ENY2", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERCC2", "ERCC3", "ERCC6L", "ERO1A", "ERP44", "ESD", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOSC1", "EXOSC10", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "F11R", "FADS2", "FAH", "FAHD1", "FAM120B", "FAM208A", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FECH", "FEN1", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FOXK1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCN1", "GDI1", "GDI2", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GLA", "GLB1", "GLDC", "GLO1", "GLS", "GLUD1", "GLYR1", "GM2A", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNPAT", "GNPDA1", "GNS", "GOT1", "GOT2", "GPD2", "GPI", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HELLS", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIC2", "HIF1AN", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HLTF", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HOXA10", "HP1BP3", "HPRT1", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HTRA2", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDI1", "IFIT5", "IGBP1", "IGF2BP1", "IGF2BP3", "IGF2R", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMP3", "IMPDH2", "INA", "INF2", "INTS11", "IQGAP1", "IRS4", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "KARS", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KHDRBS1", "KHSRP", "KIAA0391", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC2", "KLC4", "KMT2A", "KRR1", "KYAT3", "L2HGDH", "LAMP1", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LDAH", "LDHA", "LDHB", "LEMD3", "LGMN", "LIG3", "LIMA1", "LIPA", "LNPEP", "LONP1", "LPCAT1", "LRPAP1", "LRPPRC", "LRWD1", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LUC7L3", "LYAR", "LYPLA1", "MACF1", "MAGED2", "MAP1S", "MAP2K1", "MARC1", "MARCKS", "MARCKSL1", "MARK2", "MARS", "MAT2A", "MATR3", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED16", "METAP2", "METTL13", "MFN1", "MFN2", "MGEA5", "MGST2", "MGST3", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MMAB", "MMS19", "MOGS", "MORF4L1", "MOV10", "MPHOSPH10", "MPI", "MPRIP", "MPST", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSI2", "MTA1", "MTA2", "MTAP", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTR", "MYBBP1A", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAA15", "NAA40", "NAA50", "NADK2", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L4", "NARS", "NAT10", "NAXE", "NCL", "NCOA5", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFAF7", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECTIN2", "NEDD4L", "NEK9", "NELFCD", "NES", "NEU1", "NHP2", "NIFK", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOL11", "NOL6", "NOL8", "NOL9", "NONO", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDCD1", "NUDT1", "NUDT12", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUP153", "NUP98", "NUSAP1", "NXF1", "OAT", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OTUB1", "P3H1", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCMT1", "PCNA", "PCYOX1", "PDCD4", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM7", "PEBP1", "PECR", "PELP1", "PEPD", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB2", "PHC2", "PHF5A", "PHF6", "PHGDH", "PI4KB", "PIN4", "PIR", "PISD", "PITHD1", "PITRM1", "PKM", "PKN2", "PLAA", "PLBD2", "PLD3", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PMPCB", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLD1", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR2B", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1R10", "PPP5C", "PPT1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF31", "PRPF4B", "PRPF8", "PSAT1", "PSIP1", "PSMB5", "PSMB6", "PSMB7", "PSMD10", "PSMD14", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTRH2", "PTRHD1", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB18", "RAB1A", "RAB1B", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RABGAP1", "RABGGTA", "RAC1", "RACK1", "RAD21", "RAD50", "RAD51AP1", "RALA", "RALY", "RANBP1", "RANBP2", "RANGAP1", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM34", "RBM39", "RBM4", "RBM45", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "RECQL5", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC3", "RHOA", "RHOT1", "RHOT2", "RIOK2", "RIPK1", "RNASEH2A", "RNASET2", "RNF114", "RNF20", "RNF40", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPP30", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRM1", "RRM2", "RRP1B", "RRP7A", "RRP8", "RRP9", "RSF1", "RTCB", "RTRAF", "RUVBL1", "RUVBL2", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAP18", "SAP30BP", "SARNP", "SARS", "SARS2", "SART3", "SCAF1", "SCAF8", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCO1", "SCP2", "SCPEP1", "SCRIB", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC61A1", "SEC63", "SENP3", "SEPHS1", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3B1", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGPL1", "SGTA", "SHMT1", "SHMT2", "SIGMAR1", "SIN3A", "SIRT2", "SKIV2L", "SKIV2L2", "SLC1A5", "SLC27A4", "SLFN11", "SLIRP", "SLIT2", "SLK", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMCHD1", "SMN1*", "SMPD4", "SMYD3", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SOD2", "SON", "SORT1", "SPATA5", "SPCS2", "SPCS3", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SQLE", "SRCAP", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "SSU72", "STAT3", "STAU1", "STAU2", "STEAP3", "STMN1", "STRBP", "STRN4", "STT3A", "STT3B", "STUB1", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYNCRIP", "SYNE2", "TACO1", "TAF15", "TALDO1", "TAMM41", "TAP1", "TAP2", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCE", "TCEA1", "TCERG1", "TCF25", "TCP1", "TDP2", "TDRKH", "TECR", "TFAM", "TFRC", "THG1L", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM50", "TIMM8B", "TIMMDC1", "TJP1", "TK1", "TKT", "TMCO1", "TMEM109", "TMEM126B", "TMOD3", "TMTC3", "TOMM22", "TOMM34", "TOMM40", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOX4", "TP53", "TP53BP1", "TPI1", "TPM3", "TPP1", "TPP2", "TRA2A", "TRA2B", "TRAP1", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRMT10C", "TRMU", "TRNT1", "TROVE2", "TSC2", "TSFM", "TSN", "TSTA3", "TTK", "TTYH3", "TUFM", "TWF1", "TWF2", "TXNDC12", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBR4", "UBR5", "UBR7", "UBTF", "UCHL5", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC45A", "UNG", "UPF1", "UPF3B", "UROD", "USP10", "USP14", "USP36", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTRN", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIRMA", "VPS4B", "VRK1", "WARS", "WDHD1", "WDR1", "WDR18", "WDR43", "WDR5", "WRAP53", "XPNPEP1", "XPO1", "XPO5", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YEATS4", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YTHDF3", "ZADH2", "ZBTB10", "ZC3H14", "ZC3H7A", "ZC3HAV1", "ZCCHC3", "ZDHHC20", "ZFR", "ZMPSTE24", "ZNF148", "ZNF281", "ZNF318", "ZNF326", "ZNF638", "ZNF687", "ZRANB2"], "leading_proteins": ["ABCB1", "ABCC4", "ABHD10", "ACADS", "ACP2", "AIFM1", "ALDH1A2", "ALDH1B1", "ANP32B", "ASAH1", "ASNA1", "BAG6", "BAZ2A", "BRMS1L", "BTF3", "CBX3", "CHCHD3", "CIRBP", "CLPP", "CNOT7", "CNOT9", "COX2", "CPVL", "CTBP1", "CTSA", "CYP51A1", "DCTPP1", "DDX39A", "DHCR24", "DHCR7", "DHFR", "DNAJA2", 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sha256:e14dbe59dd3d6bc690395384f07bf98948ec4435cc576be11a72c578a11b35c4 +size 142067 diff --git a/protein_atlas_protein_class/consensus.joblib b/protein_atlas_protein_class/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..f9ca6166c7ea8153538cb993002509dedf92e6b3 --- /dev/null +++ b/protein_atlas_protein_class/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:b59b3f5ea6d65521cfc9c12a776e2092ded7dbb481a5b5064f2baddc6d876dc7 +size 71670 diff --git a/protein_atlas_protein_class/df_merge.tsv b/protein_atlas_protein_class/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..6e19de526571ba217f5a59122bac14e253d794e1 --- /dev/null +++ b/protein_atlas_protein_class/df_merge.tsv @@ -0,0 +1,3 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Predicted secreted proteins 16 37 3.8150160670340783 0.0001361740731578 15.29368932038835 51.737864077669904 1.393291060716792 0.256881456821794 5.463351773637434 6.9884942404294375 1.5049506819867255 0.3173597508227758 1.0 0.001720850770709 0.0045638686947611 0.0008046975933989 0.0596858327040074 +Predicted membrane proteins 109 396 3.571195401222228 0.0003553556512871 204.61650485436897 563.8058252427185 3.080866334016093 0.3028099075873978 81.17076282318972 73.52280648113661 4.068861305085399 0.4187410497068249 0.3642145098708224 0.000793973243054 9.044403377320622e-06 6.448536182901818e-06 4.422153149950213e-05 diff --git a/protein_atlas_protein_class/metrics.json b/protein_atlas_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..e51ce06d40319b246b28a1d8b9f95df14781d9ba --- /dev/null +++ b/protein_atlas_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2454, + "annotations_size": 20, + "title": "Average number of proteins per term", + "value": 407.05 +} \ No newline at end of file diff --git a/protein_atlas_protein_class/paths.json b/protein_atlas_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..5a1bc05ee54e05a7750456dbdb60a914ff25fa85 --- /dev/null +++ b/protein_atlas_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_protein_class/fragment/C340/C340_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_protein_class/result.tsv b/protein_atlas_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..eeafdab44db81119ac032d598fafeec994be4913 --- /dev/null +++ b/protein_atlas_protein_class/result.tsv @@ -0,0 +1,11 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Predicted secreted proteins 0.7555393351536469 3.8150160670340783 0.0001361740731578 0.0027199610982778 0.001361740731578 37 Q9NZ08,Q9HB40,Q02818,P61916,Q8WUJ1,O00584,P05067,P80303,O75718,Q9UMX5,P43490,O60888,Q15165,P04083,Q9BTY2,Q08380 16 +Predicted membrane proteins 0.4913885877067865 3.5711954012222273 0.0003553556512871 0.0070831713529405 0.0023690376752479 396 P30519,O60830,Q06136,Q9UIQ6,Q99595,Q567V2,Q8WTV0,P09601,Q9BQE5,Q5BJF2,Q9NS69,Q14739,Q8IXU6,O43772,Q5VW38,Q9BSK2,Q16134,Q9Y282,Q96G23,Q14849,Q8NBX0,Q9H6V9,Q16850,O60725,Q13505,Q14108,Q6NT16,O75964,O75844,Q8N4V1,O43169,Q15629,O95831,O43676,Q93050,P43307,P24390,Q9UBM7,Q9C0H2,O43657,Q9UDW1,Q9UG56,O00461,P11117,Q9Y487,Q9Y619,O95197,Q9NR28,Q3SXM5,O14880,Q86XL3,Q92804,P08183,Q9NR77,Q9H061,Q9HD45,O15439,Q15392,Q15904,P60903,O75306,P05067,Q8IV08,Q5W0Z9,Q8NC54,Q99720,Q8IWA4,P41440,O14925,Q6UXD5,Q9H2J7,P00403,Q8WY22,Q70HW3,P11279,Q9NPR9,Q9BUN8,O96005,P51809,Q9UBX3,Q9BTX1,Q70UQ0,Q8TB61,Q99523,Q9HD20,Q9H4I3,Q969V3,Q6ZRP7,Q9Y639,Q9H1E5,P42892,Q6ZXV5,Q8IYS2,Q9Y679,O43464,Q02978,Q53GQ0,Q9HDC9,Q15738,P60228,Q15041,O15173,Q10472,Q9UM00,Q9UH62,Q8IXB1,P67812,O15118,O95140 109 +Metabolic proteins 0.2950675420553807 1.89088775265714 0.0586393296696037 0.7013785540506704 0.1647569579305324 700 P30519,Q06136,Q9H773,Q8WTV0,Q08752,P50897,P16278,P09601,P48735,Q14739,O43772,Q8N4Q0,Q969T7,Q16134,Q96G23,O75874,Q14849,P43490,Q15165,Q8NBX0,Q16850,P07099,Q9H2D1,Q9UHG3,Q13510,O60725,P48449,Q9HA64,P55786,Q13126,O75964,O75844,P00374,P10619,Q16836,O43676,Q93050,Q9UBM7,P17900,O15460,Q9UDW1,Q9UG56,O94788,P04062,P11117,P35270,Q03164,Q14914,P35790,Q9Y487,P10253,Q9Y619,Q9Y680,Q9H7Z7,O14880,P06280,O60502,P08183,P40939,Q15120,O15439,O14949,Q15392,Q15904,P61421,O75306,O15382,P31930,Q9NXR7,Q8IV08,Q5W0Z9,P23786,P13674,Q9BTY2,P83916,Q9NWM8,Q99519,P41440,P13804,P30837,Q9H2J7,P00403,P16219,P20674,Q15067,Q86UY6,Q70HW3,P22695,O96028,Q16763,Q8NBN7,O75648,Q9UBX3,Q9BTX1,Q8TB61,P07237,P31751,P19388,P37198,Q8IXJ6,Q9NRN7,Q9NVE7,Q92820,Q8NFF5,Q9Y217,Q8NFH4,Q02978,P15531,O60701 109 +Enzymes 0.2863812741079306 1.873247537554519 0.0610342106673604 0.7162111123139662 0.1647569579305324 741 P30519,Q9HB40,Q06136,Q9H773,P49721,P42785,Q16740,Q9UIQ6,Q08752,Q9BV86,P50897,P16278,P09601,P48735,Q9H3G5,Q14739,Q8N4Q0,Q9UIV1,Q969T7,Q16134,Q96G23,O75874,P43490,Q15165,Q16850,P07099,Q9UHG3,Q13510,O60725,P48449,Q9HA64,P28072,P55786,Q13126,O43847,O75844,P00374,P10619,Q16836,Q9NUJ1,Q9UBM7,Q9NZ08,O15460,Q9UG56,P20618,O94788,P04062,P11117,P35270,Q03164,Q14914,Q8NB78,P35790,P10253,Q99797,P28070,Q9Y680,Q9H7Z7,O14880,P06280,O60502,P08183,P40939,Q15120,O15439,Q15392,O75306,O15382,P31930,Q8IV08,Q5W0Z9,P23786,O00148,P13674,Q9BTY2,P11233,Q9NWM8,Q99519,O00584,P30837,P18074,P00403,P16219,Q15067,Q86UY6,P60900,P22695,O96028,Q16763,Q86W56,Q8NBN7,O75648,Q9H0R6,Q6ZRP7,P07237,P31751,Q9BQC3,Q5JRX3,Q99436,P42892,Q6ZXV5,Q8IXJ6,Q9NRN7,Q92820,Q8NFF5,Q9Y217,O43464,P15531,O60701 109 +FDA approved drug targets 0.3942326373921958 1.8390843318462344 0.0659027831722129 0.7442347359907406 0.1647569579305324 93 P05067,P49721,P20618,Q16134,O75874,Q99720,P07437,P23786,P00374,Q16836,Q16850,P48735,P10253,P68371 14 +Transporters 0.3815812886163618 1.1610339257519575 0.2456281031125435 0.9964378679129712 0.5100559273056609 294 Q9Y619,Q8TB61,Q99523,Q9HD20,Q969V3,Q8WTV0,P08183,Q6NUK1,Q9NR77,Q9H061,Q9Y639,O15439,Q5BJF2,Q15904,P37198,P45880,Q8IXU6,P61421,O43772,P60903,Q5VW38,P05067,Q6ZXV5,Q9BSK2,Q9BRK5,Q8NFH4,Q14849,Q5W0Z9,Q02978,Q9H2D1,Q99720,Q9UI26,Q14108,Q6NT16,Q8IWA4,P41440,P61916,O75340,O75844,Q8N4V1,Q9H2J7,Q15629,P04083,P00403,Q9Y5S9,P20674,Q9UM00,Q93050,Q8WY22,P24390,Q9C0H2,Q70HW3,P11279,O15118,O95140,Q9BUN8,P49069,O96005,Q92973,Q9BTX1,Q9UBX3,O43681 62 +Citric acid cycle related proteins 0.3903007281581258 0.8272132540509199 0.4081162005997671 0.9999721561645176 0.5251073790826163 24 P48735 1 +CD markers 0.4620951309100176 0.8200410312247568 0.4121927167833488 0.9999757506971328 0.5251073790826163 11 P08183 1 +Human disease related genes 0.2533537576824892 0.8062722225168021 0.4200859032660931 0.9999814956720464 0.5251073790826163 738 Q9UHX1,Q06136,Q16740,P50897,P16278,P09601,Q9BQE5,P48735,Q14739,O43772,Q16134,O75874,P07437,Q8WWV3,P07099,O75503,Q13510,P68371,Q14108,P48449,Q9BVA1,O75844,P00374,P10619,Q16836,O95831,O43676,Q9UBM7,Q6DKK2,P17900,O15460,P04062,P11117,P35270,P35637,Q03164,Q5XKP0,O14979,Q9Y487,P10253,Q99797,Q9Y619,Q9NR28,P04792,Q9H7Z7,O95721,P06280,Q86XL3,P08183,P35250,Q9NR77,Q9H061,P40939,Q15120,O14949,Q15392,Q9Y375,Q13501,O75306,P07737,P05067,Q8IV08,P23786,Q9NWM8,Q99720,Q99519,P61916,P13804,O00584,O75718,P18074,P00403,P16219,Q15067,Q9BW83,Q96EK5,Q70HW3,Q15056,Q96GM8,P22695,O96028,P22626,Q14738,Q15555,Q9Y4P3,O75648,Q9H0R6,Q9UBX3,Q86YV9,Q01105,Q13409,P07237,Q6NUK1,P31751,P31483,P37198,P42892,Q6ZXV5,Q8NFH4,O43464,O60701,Q969G3,Q8N0X7,Q15738,P38159,Q96P11,Q15041,Q9Y5S9,Q9UM00,Q96J02,Q00059,O43505,O15118,O95140,P61978,Q9Y263,P54802,P49366,P17812,P04899,P51648,Q13642,Q9P032,Q8N183,Q13155,P21964,P10321,Q9Y2Q5,Q16204,P09651,Q13423,O75880,P10644,P15586 134 +RAS pathway related proteins 0.3246105144661668 0.2502014131354784 0.8024315924810659 0.9999999999999918 0.9440371676247834 16 P61020,P31751,P11233 3 diff --git a/protein_atlas_protein_class/selections.json b/protein_atlas_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..48537c68ad4a2c2ccee76a2f8dc1ea0169f3a85c --- /dev/null +++ b/protein_atlas_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Blood group antigen proteins", "CD markers", "Cancer-related genes", "Candidate cardiovascular disease genes", "Citric acid cycle related proteins", "Disease related genes", "Enzymes", "FDA approved drug targets", "Human disease related genes", "Metabolic proteins", "Plasma proteins", "Potential drug targets", "Predicted intracellular proteins", "Predicted membrane proteins", "Predicted secreted proteins", "RAS pathway related proteins", "RNA polymerase related proteins", "Ribosomal proteins", "Transcription factors", "Transporters"], "available_proteins": ["AAAS", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABHD10", "ABHD12", "ABHD6", "ACAA2", "ACACA", "ACACB", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ACTR6", "ADAM17", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "AKT2", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "AMOT", "ANAPC1", "ANAPC16", "ANAPC5", "ANAPC7", "ANK3", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOL2", "APOO", "APP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG4B", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "B4GAT1", "BABAM1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCL2L12", "BCLAF1", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPTF", "BRCA1", "BRD2", "BRI3BP", "BRIX1", "BRMS1L", "BROX", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BYSL", "BZW1", "C12orf43", "C12orf73", "C15orf39", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C5orf15", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC47", "CCDC6", "CCDC86", "CCDC97", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD3EAP", "CDC123", "CDC23", "CDC27", "CDC34", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CDKAL1", "CEBPZ", "CECR2", "CELF1", "CENPB", "CENPI", "CEP170", "CERS2", "CFAP20", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD4", "CHERP", "CHID1", "CHKA", "CHMP3", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT10", "CNOT3", "CNOT6", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG7", "COIL", "COLGALT1", "COMMD2", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "CORO1B", "CORO1C", "COTL1", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DGCR8", "DGUOK", "DHCR24", "DHCR7", "DHFR", "DHPS", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK7", "DOHH", "DPF2", "DPH2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELP1", "ELP2", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "ENSA", "ENY2", "EPB41", "EPB41L2", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERGIC3", "ERH", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC5", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120B", "FAM162A", "FAM208A", "FAM49B", "FAM8A1", "FAM98A", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FOXK1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GIGYF2", "GINS1", "GINS4", "GLA", "GLB1", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGA3", "GOLGB1", "GOLIM4", "GORASP2", "GOT1", "GOT2", "GPAA1", "GPD2", "GPI", "GPR107", "GPR108", "GPRASP2", "GPS1", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTO1", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAUS5", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HERC2", "HEXA", "HEXB", "HIBADH", "HIBCH", "HIC2", "HIF1AN", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOXA10", "HP1BP3", "HPF1", "HPRT1", "HPS6", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMPDH2", "INA", "INCENP", "INF2", "INTS11", "INTS14", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRGQ", "IRS4", "ISOC1", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JPT2", "JUP", "KARS", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDSR", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIAA2013", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIFC1", "KLC2", "KLC4", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMP1", "LAMTOR1", "LAMTOR2", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDAH", "LDHA", "LDHB", "LEMD3", "LETM1", "LGALS3BP", "LGMN", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM6", "LSS", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L3", "LYAR", "LYPLA1", "MACF1", "MAGED2", "MAGT1", "MAK16", "MAP1B", "MAP1S", "MAP2K1", "MAP4", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARCKSL1", "MARK2", "MARS", "MAT2A", "MATR3", "MAU2", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED16", "METAP2", "METTL13", "MFN1", "MFN2", "MGEA5", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMGT1", "MMS19", "MOB4", "MOGS", "MORF4L1", "MOV10", "MPHOSPH10", "MPI", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MYBBP1A", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAGK", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA5", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFAF7", "NDUFB11", "NDUFB3", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFCD", "NEMF", "NENF", "NES", "NEU1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NPTN", "NRBP1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT12", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUSAP1", "NUTF2", "NVL", "NXF1", "OAT", "OCIAD1", "OCLN", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL11", "OSBPL6", "OSBPL9", "OTUB1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIGS", "PIGT", "PIN4", "PIR", "PISD", "PITHD1", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLAA", "PLBD2", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1R10", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PPP6R3", "PPT1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSMG3", "PSPC1", "PTBP1", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTRH2", "PTRHD1", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB35", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RABGGTA", "RABL6", "RAC1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAD51AP1", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM34", "RBM39", "RBM4", "RBM45", "RBM5", "RBM8A", "RBMX", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "RECQL5", "REEP5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOG", "RHOT1", "RHOT2", "RIF1", "RINT1", "RIOK2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF114", "RNF20", "RNF40", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPA3", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF8", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SEZ6L2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A33", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35B2", "SLC35F2", "SLC3A2", "SLC6A15", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX12", "SNX2", "SNX3", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPCS2", "SPCS3", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SQLE", "SQSTM1", "SRCAP", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPK2", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "SSU72", "STAG2", "STARD3", "STAT3", "STAU1", "STAU2", "STEAP3", "STIP1", "STMN1", "STOML2", "STRAP", "STRBP", "STRN4", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TACO1", "TAF15", "TAGLN2", "TALDO1", "TAMM41", "TAP1", "TAP2", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF25", "TCOF1", "TCP1", "TDP2", "TDRKH", "TECR", "TELO2", "TEX10", "TFAM", "TFG", "TFRC", "THG1L", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMMDC1", "TIPRL", "TJP1", "TJP2", "TK1", "TKT", "TLN1", "TM9SF3", "TMCO1", "TMED10", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM126B", "TMEM192", "TMEM201", "TMEM205", "TMEM214", "TMEM230", "TMEM33", "TMEM43", "TMEM65", "TMEM97", "TMOD3", "TMTC3", "TMX1", "TMX2", "TMX4", "TNKS1BP1", "TNPO1", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOX4", "TP53", "TP53BP1", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC5", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRMT6", "TRMU", "TRNT1", "TROVE2", "TSC2", "TSFM", "TSG101", "TSN", "TSPAN6", "TSR1", "TSTA3", "TTC1", "TTC19", "TTC21B", "TTC26", "TTC37", "TTC38", "TTC4", "TTK", "TTLL12", "TTYH3", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBL5", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UCHL5", "UFC1", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF3B", "UQCR10", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USMG5", "USO1", "USP10", "USP14", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VPS13A", "VPS16", "VPS18", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WBP11", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR43", "WDR45B", "WDR46", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WDR82", "WDR91", "WFS1", "WIZ", "WRAP53", "XAB2", "XPNPEP1", "XPO1", "XPO4", "XPO5", "XPO7", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YEATS2", "YEATS4", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBTB10", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZDHHC20", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZNF148", "ZNF281", "ZNF318", "ZNF326", "ZNF638", "ZNF687", "ZRANB2", "ZW10", "ZYX"], "leading_proteins": ["AASDHPPT", "ABCB1", "ABCC4", "ABHD10", "ACADS", "ACOX1", "ACP2", "AIFM1", "AIMP2", "AKT2", "ALDH1A2", "ALDH1B1", "ALDH3A2", "ANKLE2", "ANXA1", "APMAP", "APOL2", "APP", "ARL6IP1", "ARMCX3", "ASAH1", "ASNA1", "ATP13A1", "ATP5L", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "AUP1", "B4GAT1", "BABAM2", "BCAT2", "BRI3BP", "C19orf70", "C5orf15", "CAMLG", "CBX1", "CCDC6", "CERS2", "CHKA", "CLN5", "CLPP", "CLPTM1", "CNOT7", "COMT", "COX2", "COX5A", "CPT2", "CPVL", "CRTAP", "CTPS1", "CTSA", "CUTA", "CYB5B", "CYB5D2", "CYP51A1", "DCTPP1", "DDX39A", "DERL1", "DHCR24", "DHCR7", "DHFR", "DHPS", "DIABLO", "DNAJC10", "DPH2", "DYNC1I2", "ECE1", "EIF3E", "EIF4H", "EPHX1", "ERAP1", "ERCC2", "ERGIC3", "ETFA", "ETFDH", "FHL1", "FKBP14", "FKBP7", "FLAD1", "FN3KRP", "FUCA2", "FUS", "GAA", "GALNT1", "GBA", "GGH", "GLA", "GLB1", "GM2A", "GNAI2", "GNS", "GOLIM4", "GPR107", "GPR108", "HADH", "HADHA", "HLA-C", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPK", "HPS6", "HSD17B12", "HSDL1", "HSPB1", "HTRA2", "ICMT", "IDH1", "IDH2", "IFT27", "IKBIP", "IPO11", "ITCH", "KDELR1", "KDM1B", "KDSR", "KIAA2013", "KIFBP", "KMT2A", "LAMP1", "LAMTOR2", "LBR", "LDAH", "LGALS3BP", "LNPEP", "LSS", "MAPRE2", "MFN1", "MFN2", "MGEA5", "MGST3", "MIPEP", "MMGT1", "MPV17L2", "MTAP", "MTMR6", "MTX1", "NAA40", "NAGLU", "NAMPT", "NCLN", "NDC1", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFB3", "NDUFS2", "NENF", "NEU1", "NME1", "NNT", "NPC1", "NPC2", "NPEPPS", "NPTN", "NRDC", "NSD2", "NSDHL", "NSUN5", "NT5C3B", "NTMT1", "NUCB1", "NUCB2", "NUP37", "NUP62", "P4HA1", "P4HA2", "P4HB", "PANK4", "PARG", "PCYOX1", "PDCD6", "PDK3", "PFN1", "PGRMC2", "PISD", "PITRM1", "PLAA", "PLD3", "POLR2E", "PON2", "PPID", "PPP2R5D", "PPT1", "PRCP", "PRKAR1A", "PSMA6", "PSMB1", "PSMB2", "PSMB4", "PSMB6", "PSMB7", "PTGES2", "PTGR1", "PUF60", "PXMP2", "QRSL1", "QSOX2", "RAB5B", "RALA", "RBM8A", "RBMX", "RDH13", "RFC2", "RNASET2", "RTN3", "RTN4IP1", "S100A10", "SCARB1", "SCARB2", "SCCPDH", "SCO1", "SCPEP1", "SDF4", "SEC11A", "SET", "SEZ6L2", "SIGMAR1", "SIRT2", "SLC18B1", "SLC19A1", "SLC25A10", "SLC25A11", "SLC25A15", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A32", "SLC25A33", "SLC35B2", "SLC35F2", "SLC6A15", "SMARCE1", "SNAP29", "SORT1", "SPART", "SPR", "SQSTM1", "SSR1", "STARD3", "TAF15", "TBL2", "TFAM", "TIA1", "TIMM17A", "TIMM17B", "TIMM23", "TM9SF3", "TMCO1", "TMEM126A", "TMEM97", "TMTC3", "TMX4", "TNPO1", "TOE1", "TOMM22", "TRABD", "TRAM1", "TRMU", "TSPAN6", "TTC19", "TTYH3", "TUBB", "TUBB2B", "TUBB4B", "UBE2S", "UGDH", "UQCR10", "UQCRC1", "UQCRC2", "UQCRQ", "VAMP7", "VDAC2", "ZADH2", "ZDHHC20", "ZMPSTE24"]} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/advanced/idx2term.json 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0000000000000000000000000000000000000000..8b8fbb04d6cece5d4c53458898bfcf928dd0f675 --- /dev/null +++ b/protein_atlas_subcellular_location_all/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:3932d7ae9ccb52704f91b611631f8e857b1d154af652d3c9522afe88c1563005 +size 64699 diff --git a/protein_atlas_subcellular_location_all/df_merge.tsv b/protein_atlas_subcellular_location_all/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..393f6b8320a686d4285d7527d9751a129c3725e3 --- /dev/null +++ b/protein_atlas_subcellular_location_all/df_merge.tsv @@ -0,0 +1,4 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Golgi apparatus 29 121 2.756284464233729 0.0058462128615048 46.45873786407767 176.03155339805826 1.3643789213018729 0.3972771337532677 14.511319530749702 26.453870355965975 1.6568954592349954 0.4161874156663988 1.0 0.0036751206154296 0.0252016215986715 0.114773009712369 0.2878532155325714 +Microtubules 11 38 2.329697193553129 0.0198221609855662 11.762135922330096 51.536407766990294 0.1467824701124027 0.6383504938877967 6.107191630577272 6.9907105288235005 0.8576674618245522 0.3225755572425843 1.0 0.0515367168579561 0.0070528673092062 0.0614679474855292 0.0423262825192943 +Mitotic spindle 3 16 2.0302806787636403 0.042328017032496 8.230582524271844 22.633495145631063 -0.213814458319639 0.5636457653325838 4.148076715462782 3.2915225646599717 0.9898553726584056 0.3255608820421566 1.0 0.2480154974279715 0.0025290933815156 0.053649406266927 0.3148491478678726 diff --git a/protein_atlas_subcellular_location_all/metrics.json b/protein_atlas_subcellular_location_all/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..ea499961ec68b2b57358bc672212f3b2f84458bc --- /dev/null +++ b/protein_atlas_subcellular_location_all/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2454, + "annotations_size": 33, + "title": "Average number of proteins per term", + "value": 116.06060606060606 +} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/paths.json b/protein_atlas_subcellular_location_all/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..155ddd3b784c4207658dd5279ee9a18820fee2d1 --- /dev/null +++ b/protein_atlas_subcellular_location_all/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_subcellular_location_all/fragment/C340/C340_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/result.tsv b/protein_atlas_subcellular_location_all/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..a4beb90d19ce78b5cb9c2d1604a07640e9b34bee --- /dev/null +++ b/protein_atlas_subcellular_location_all/result.tsv @@ -0,0 +1,11 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Golgi apparatus 0.4658917133127608 2.756284464233729 0.0058462128615048 0.1759228892430834 0.130826262504737 121 Q9HB40,Q99523,P80303,Q6ZRP7,P35250,P50897,P16278,P09601,Q9HD45,O15439,Q8IXU6,Q02818,Q8N4Q0,Q5VW38,P05067,Q8IYS2,Q9BRK5,Q8NC54,Q9NWM8,Q6NT16,Q9UH62,Q93050,P24390,P67812,Q9NPR9,Q9UG56,Q9H8Y8,O00461,P40616 29 +Microtubules 0.5421422524595673 2.329697193553129 0.0198221609855662 0.4835110724736396 0.130826262504737 38 O60830,Q02818,Q9BUF5,Q9NWY4,Q9BVA1,O43813,Q13409,P07437,P61163,Q9Y2I1,P68371 11 +Mitotic spindle 0.6167848291725273 2.0302806787636403 0.042328017032496 0.7600317349994986 0.1995463660103383 16 Q9BUF5,P07437,P68371 3 +Cytokinetic bridge 0.5608876245533989 1.9486569680694568 0.0513364039758827 0.8243275067983243 0.2117626664005165 22 Q9BUF5,Q9NWY4,Q9BVA1,P07437,P68371 5 +Focal adhesion sites 0.464875576909631 1.3333289834142823 0.1824238663169703 0.9987015334293272 0.4116502013372728 23 O60888,Q9Y487,P08183,Q9UHB6 4 +Lipid droplets 0.6181485622442943 1.2473983936330084 0.2122514552749093 0.9996191174160824 0.4377686265045004 7 Q15738,Q01105,Q969V3 3 +Endoplasmic reticulum 0.3472132667160722 0.9390602586814756 0.3476998069174579 0.9999992470472332 0.6374496460153396 168 O95197,Q70UQ0,Q8WUJ1,Q9Y680,Q86XL3,Q13409,Q5BJF2,Q9H3G5,Q8IV08,Q96G23,Q14849,P13674,Q14257,Q16850,O43169,P43307,Q9UBM7,O15460,Q9BUN8,O96005,P35790,O43852,Q92791 23 +Vesicles 0.3221761378018475 0.3540691383035119 0.7232870699133445 1.0 0.9219409788979516 216 P30519,Q8TB61,Q9HD20,P42785,Q3SXM5,Q8WTV0,P50897,P16278,Q9HD45,Q13501,Q8N4Q0,Q9NRY5,P05067,P61020,Q14849,Q5W0Z9,P13674,Q8NBX0,Q99519,Q9H2J7,O75153,Q01085,P10619,Q93050,P24390,Q9NUD5,P17900,O15460,Q9NPR9,P51809,Q9Y2I1,Q86W56,Q9Y487,Q9H0R6,P10253,Q92791,Q00169 37 +Mitochondria 0.3249207038697903 0.2796010209488475 0.7797836237277855 1.0 0.9530688734450712 326 Q9UJS0,O60830,Q16740,Q99595,P48735,Q9NS69,P45880,O43772,Q9H2D1,Q13505,O75964,P00374,Q16836,Q69YU5,O95831,Q9NUJ1,Q6DKK2,Q9NSK0,Q5XKP0,Q14168,Q99797,P28070,Q9NR28,Q9H7Z7,Q3SXM5,Q8N4H5,P40939,Q15120,O14949,Q9Y375,P60903,O75306,O15382,P31930,P23786,P13674,Q8IWA4,P13804,O14925,P30837,Q9NX63,P16219,Q8WY22,Q9UII2,Q70HW3,P22695,Q8NBN7,O75648,Q9UBX3,Q9H4I3,Q6NUK1,Q5JRX3,Q8TAE8,O43464,Q96CX2,Q9Y277,Q00059,O75431,O95140,Q9BXW7,Q5VT66,Q9P032,Q96SY0,Q8N183,Q9NX40,Q13423,O60645,Q8NCN5,Q4G0N4,P23919,O75947,Q96IX5,Q96BR5,Q15785,Q9Y3E5,Q8IUX1,Q96EY8,P56134,Q9HC21,Q15388,P12235,Q9NPL8,Q92552,P24539,Q07021,Q7Z4V5,Q96A26,Q96AY3 88 +Peroxisomes 0.3286887862405698 0.1756706362684943 0.8605527053782549 1.0 0.979249630258014 11 Q15067,O43808 2 diff --git a/protein_atlas_subcellular_location_all/selections.json b/protein_atlas_subcellular_location_all/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..0451b54d1ab40db07452f9e19774a291b69abc8f --- /dev/null +++ b/protein_atlas_subcellular_location_all/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin filaments", "Cell Junctions", "Centriolar satellite", "Centrosome", "Cytokinetic bridge", "Cytoplasmic bodies", "Cytosol", "Endoplasmic reticulum", "Endosomes", "Focal adhesion sites", "Golgi apparatus", "Intermediate filaments", "Kinetochore", "Lipid droplets", "Lysosomes", "Microtubule ends", "Microtubules", "Midbody", "Midbody ring", "Mitochondria", "Mitotic chromosome", "Mitotic spindle", "Nuclear bodies", "Nuclear membrane", "Nuclear speckles", "Nucleoli", "Nucleoli fibrillar center", "Nucleoli rim", "Nucleoplasm", "Peroxisomes", "Plasma membrane", "Rods & Rings", "Vesicles"], "available_proteins": ["AAAS", "AARS", "AARS2", "AARSD1", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABHD10", "ABHD6", "ACAA2", "ACACA", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACP1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR6", "ADAM17", "ADAR", "ADD1", "ADD3", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK6", "AKAP1", "AKAP12", "AKAP13", "AKAP17A", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "AMOT", "ANAPC1", "ANAPC16", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANKRD17", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOO", "APP", "APRT", "ARCN1", "ARFGAP1", "ARG2", "ARHGDIA", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6IP1", "ARL6IP5", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC3", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG4B", "ATIC", "ATL2", "ATP13A1", "ATP1B3", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6V0A1", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "BABAM1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1B", "BAZ2A", "BCAP31", "BCAS2", "BCAT2", "BCCIP", "BCL2L12", "BCLAF1", "BIRC6", "BLM", "BLMH", "BLVRA", "BMS1", "BOLA2*", "BOP1", "BPTF", "BRCA1", "BRD2", "BRI3BP", "BRIX1", "BRMS1L", "BROX", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BYSL", "BZW1", "C12orf43", "C12orf73", "C15orf39", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C5orf15", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAMLG", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC124", "CCDC47", "CCDC6", "CCDC86", "CCDC97", "CCT2", "CCT3", "CCT4", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD3EAP", "CDC123", "CDC27", "CDC34", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDK6", "CEBPZ", "CECR2", "CELF1", "CENPB", "CENPI", "CEP170", "CERS2", "CFAP20", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD4", "CHID1", "CHKA", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CHTF18", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLINT1", "CLNS1A", "CLPP", "CLPTM1", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT10", "CNOT3", "CNOT6", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG7", "COIL", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "CORO1B", "COTL1", "COX4I1", "COX5B", "COX6C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF6", "CPSF7", "CPT2", "CPVL", "CRKL", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTDSPL2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTTN", "CUL1", "CUL2", "CUL4A", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R1", "CYB5R3", "CYC1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF13", "DCAF7", "DCAKD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DFFA", "DGCR8", "DHCR7", "DHFR", "DHPS", "DHRS7", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DIDO1", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJC1", "DNAJC11", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOHH", "DPF2", "DPH2", "DPP3", "DPP9", "DPYSL2", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1I2", "DYNC1LI1", "DYNLL1", "EBNA1BP2", "ECH1", "ECHS1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFL1", "EFTUD2", "EHD1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELOA", "ELP1", "ELP2", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "ENSA", "ENY2", "EPB41", "EPB41L2", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC6L", "ERH", "ERLIN2", "ERP29", "ESD", "ESF1", "ESYT1", "ESYT2", "ETFA", "ETFB", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC3", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC3", "EXOSC5", "EXOSC7", "EZR", "F11R", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120B", "FAM162A", "FAM208A", "FAM49B", "FAM8A1", "FAM98A", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBL", "FDFT1", "FDPS", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP7", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FOXC1", "FOXK1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALK1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATB", "GBF1", "GCAT", "GCC2", "GCDH", "GCN1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GIGYF2", "GINS1", "GINS4", "GLB1", "GLDC", "GLE1", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GOLGA3", "GOLGB1", "GOLIM4", "GORASP2", "GOT1", "GPAA1", "GPD2", "GPI", "GPR107", "GPR108", "GPRASP2", "GPS1", "GRB2", "GRHPR", "GRIPAP1", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM3", "GSTZ1", "GTF2E1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GTPBP4", "GUSB", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HADH", "HADHA", "HADHB", "HAT1", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HERC2", "HEXA", "HIBCH", "HIC2", "HIF1AN", "HINT2", "HIST1H1C", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLCS", "HLTF", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HOXA10", "HP1BP3", "HPF1", "HPRT1", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPH1", "HTRA2", "HTT", "HUWE1", "IARS", "IARS2", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IFIT5", "IGBP1", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILK", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMPDH2", "INA", "INCENP", "INF2", "INTS11", "INTS14", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IRGQ", "ISOC1", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "JPT2", "JUP", "KARS", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KEAP1", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIAA2013", "KIF11", "KIF14", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "KLC2", "KLC4", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMTOR1", "LAMTOR2", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LEMD3", "LETM1", "LGMN", "LIG3", "LIMA1", "LIPA", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM6", "LTA4H", "LTN1", "LTV1", "LUC7L", "LUC7L3", "LYAR", "LYPLA1", "MACF1", "MAGED2", "MAK16", "MAP1B", "MAP1S", "MAP2K1", "MAP4", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARCKSL1", "MARK2", "MARS", "MAT2A", "MATR3", "MAU2", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED16", "METAP2", "METTL13", "MFN1", "MFN2", "MGEA5", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MIPEP", "MKI67", "MMAB", "MMS19", "MOGS", "MORF4L1", "MOV10", "MPHOSPH10", "MPI", "MPP2", "MPRIP", "MPST", "MRE11", "MRI1", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL21", "MRPL28", "MRPL37", "MRPL38", "MRPL39", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRRF", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH2", "MTDH", "MTFP1", "MTHFD1L", "MTHFD2", "MTIF2", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MYBBP1A", "MYG1", "MYH10", "MYH14", "MYH9", "MYO1B", "MYO1C", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NADK2", "NAGK", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NAPG", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDUFA10", "NDUFA11", "NDUFA4", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFB11", "NDUFB4", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NECTIN2", "NEFL", "NEFM", "NELFCD", "NEMF", "NES", "NEU1", "NHLRC2", "NIFK", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP16", "NOP2", "NOP53", "NOP56", "NOP58", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NPTN", "NRBP1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NT5DC1", "NTMT1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDT1", "NUDT16L1", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP188", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUPL2", "NUSAP1", "NVL", "NXF1", "OAT", "OCIAD1", "OCLN", "OGDH", "OGFOD1", "OGT", "OLA1", "OPA1", "OPA3", "OSBP", "OSBPL11", "OSBPL6", "OSBPL9", "OTUB1", "P3H1", "P3H4", "P4HA1", "P4HA2", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARG", "PARK7", "PARN", "PARP1", "PARP2", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCM1", "PCMT1", "PCNA", "PCNP", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDLIM7", "PDPR", "PDS5A", "PDS5B", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PGAM1", "PGAM5", "PGD", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PI4KB", "PICALM", "PIN4", "PIR", "PISD", "PITPNA", "PITPNB", "PITRM1", "PKM", "PKN2", "PLAA", "PLD3", "PLEC", "PLIN3", "PLOD1", "PLOD2", "PLRG1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLRMT", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPID", "PPIF", "PPIG", "PPIL1", "PPIL4", "PPM1G", "PPME1", "PPP1CA", "PPP1R10", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP5C", "PPP6R3", "PPT1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PRIM2", "PRKACA", "PRKAR1A", "PRKCSH", "PRKDC", "PRMT1", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA4", "PSMA5", "PSMA6", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSMG2", "PSPC1", "PTBP1", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR2", "PTPA", "PTPN1", "PTRH2", "PTRHD1", "PUF60", "PUM3", "PUS1", "PUS7", "PWP1", "PWP2", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "RAB13", "RAB14", "RAB1A", "RAB1B", "RAB24", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABGAP1", "RABL6", "RAC1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAD51AP1", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RARS", "RARS2", "RAVER1", "RBBP6", "RBM10", "RBM12", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM34", "RBM39", "RBM4", "RBM45", "RBM5", "RBM8A", "RBMX", "RCC1", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH13", "RDX", "RECQL", "RECQL5", "REEP5", "REPS1", "RER1", "RETSAT", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT2", "RIF1", "RINT1", "RIOK2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNF114", "RNF20", "RNF40", "RNPEP", "RNPS1", "ROCK2", "RP2", "RPA1", "RPAP3", "RPF2", "RPL10", "RPL10A", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL32", "RPL34", "RPL35", "RPL36", "RPL36A", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP1", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS28", "RPS3", "RPS3A", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCB", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF8", "SCAMP1", "SCAMP2", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC16A", "SEC23A", "SEC23IP", "SEC24A", "SEC24B", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SENP3", "SEPHS1", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SGPL1", "SGTA", "SH3BGRL2", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SIN3A", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC18B1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC33A1", "SLC35B2", "SLC35F2", "SLC3A2", "SLC6A15", "SLC9A3R1", "SLFN11", "SLIRP", "SLK", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SNAP29", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPC", "SNRPD2", "SNRPD3", "SNW1", "SNX1", "SNX2", "SNX6", "SNX9", "SOD2", "SON", "SORT1", "SPAG9", "SPART", "SPATA5", "SPCS2", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SQLE", "SQSTM1", "SRCAP", "SRI", "SRM", "SRP14", "SRP19", "SRP54", "SRP68", "SRPK1", "SRPK2", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF2", "SRSF3", "SRSF4", "SRSF5", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "SSU72", "STAG2", "STARD3", "STAT3", "STAU1", "STAU2", "STEAP3", "STIP1", "STMN1", "STOML2", "STRAP", "STRN4", "STT3B", "STUB1", "STX12", "STX18", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TACO1", "TAF15", "TAGLN2", "TALDO1", "TAMM41", "TAP1", "TAP2", "TARDBP", "TARS", "TARS2", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TDP2", "TDRKH", "TECR", "TELO2", "TEX10", "TFAM", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMMDC1", "TIPRL", "TJP1", "TJP2", "TKT", "TLN1", "TM9SF3", "TMCO1", "TMED10", "TMEM109", "TMEM126A", "TMEM126B", "TMEM192", "TMEM201", "TMEM205", "TMEM214", "TMEM230", "TMEM97", "TMOD3", "TMX1", "TMX2", "TMX4", "TNKS1BP1", "TNPO1", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOX4", "TP53", "TP53BP1", "TPD52", "TPD52L2", "TPI1", "TPM3", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAP1", "TRAPPC11", "TRAPPC5", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRMT10C", "TRMT6", "TRMU", "TRNT1", "TROVE2", "TSC2", "TSFM", "TSG101", "TSN", "TSPAN6", "TSR1", "TSTA3", "TTC1", "TTC19", "TTC21B", "TTC37", "TTC38", "TTC4", "TTK", "TTLL12", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3C", "UBE4A", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UCHL5", "UFC1", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC45A", "UNG", "UPF1", "UPF3B", "UQCRC1", "UQCRC2", "UQCRQ", "UROD", "USMG5", "USO1", "USP10", "USP14", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VBP1", "VCL", "VCP", "VDAC2", "VDAC3", "VIM", "VIRMA", "VPS26A", "VPS29", "VPS33A", "VPS35", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WBP11", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR4", "WDR45B", "WDR46", "WDR5", "WDR6", "WDR61", "WDR77", "WDR82", "WIZ", "WRAP53", "XAB2", "XPNPEP1", "XPO1", "XPO4", "XPO5", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YEATS2", "YEATS4", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAQ", "ZADH2", "ZBTB10", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZDHHC20", "ZFR", "ZFYVE16", "ZMYM2", "ZMYM4", "ZNF148", "ZNF281", "ZNF318", "ZNF326", "ZNF638", "ZNF687", "ZRANB2", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ABCC4", "ABHD10", "ACADS", "ACOX1", "ACTR1A", "AIFM1", "ALDH1B1", "ANKLE2", "APP", "ARL1", "ARMCX3", "ATP13A1", "ATP5F1", "ATP5H", "ATP5J2", "ATP5L", "ATP6V0A1", "ATP6V0A2", "ATPIF1", "BCAT2", "BRI3BP", "C12orf73", "C19orf70", "C1QBP", "C5orf15", "CALU", "CERS2", "CHCHD3", "CHKA", "CLPP", "CLPTM1", "CLUH", "COA7", "CPT2", "CPVL", "CTSA", "CUTA", "CYB5B", "CYB5D2", "CYP51A1", "DERL1", "DHCR7", "DHFR", "DIABLO", "DTYMK", "DYNC1I2", "ETFA", "EXOC3", "FAM114A2", "FAM162A", "FKBP10", "FKBP14", "FKBP7", "GAA", "GADD45GIP1", "GLB1", "GM2A", "GOLIM4", "GORASP2", "GPR107", "GPR108", "HADH", "HADHA", "HDGFL2", "HDHD5", "HMOX1", "HMOX2", "HPF1", "HSDL1", "HTRA2", "IDH2", "IKBIP", "INTS14", "KCTD12", "KDELR1", "KIAA2013", "KLC4", "LANCL1", "LIMA1", "MARC1", "MFN1", "MFN2", "MIPEP", "MMAB", "MPP2", "MRPS27", "MTX1", "MTX2", "NADK2", "NCLN", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFS2", "NEU1", "NISCH", "NNT", "NSDHL", "NUCB1", "NUCB2", "OCIAD1", "P3H4", "P4HA1", "P4HA2", "PARG", "PDK3", "PDPR", "PISD", "PITPNA", "PITRM1", "PLD3", "PPT1", "PRCP", "PSMB4", "PTGES2", "PTRH2", "QRSL1", "QSOX2", "RAB5B", "RCN2", "RDH13", "RFC2", "RTN3", "S100A10", "SCARB1", "SCCPDH", "SCPEP1", "SDF4", "SEC11A", "SET", "SLC18B1", "SLC25A10", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A32", "SLC25A4", "SLC35B2", "SLC35F2", "SLC6A15", "SORT1", "SQSTM1", "SSR1", "STARD3", "TFAM", "TIAL1", "TIMM17A", "TIMM17B", "TIMM23", "TIMMDC1", "TM9SF3", "TMEM126B", "TMEM97", "TOMM20", "TOMM22", "TOMM34", "TOMM5", "TRABD", "TRMU", "TTC19", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "UQCRC1", "UQCRC2", "UQCRQ", "USMG5", "VAMP7", "VDAC2", "VDAC3", "ZADH2", "ZCCHC3", "ZDHHC20"]} \ No newline at end of file