Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size Sphingolipid metabolism 0.8008610039743459 3.388709236249699 0.0007022243031782 0.6038081634133816 0.1640822169757951 22 P17900,Q06136,P06280,Q96G23,P04062,P10619,P16278,Q13510,O43681 9 Glycosphingolipid metabolism 0.8579257774942916 3.1560725230042435 0.0015990909498608 0.8786757777352311 0.1640822169757951 14 P17900,P06280,P04062,P10619,P16278,Q13510,O43681 7 Metabolism of lipids 0.4965875396757898 3.0833452506874215 0.0020468753491031 0.9328312047018686 0.1640822169757951 126 Q06136,Q9H7Z7,P06280,P50897,P16278,P40939,Q15392,Q14739,O43772,Q8IV08,Q96G23,Q14849,P23786,Q15165,Q16850,Q13510,Q99519,P48449,P10619,Q16836,P16219,Q9UBM7,P17900,Q9UG56,P04062,Q14914,P35790,O43681 28 Selective autophagy 0.6599223032103947 2.739063038384217 0.0061614558195184 0.9997100841888572 0.1640822169757951 25 Q13501,Q8IWA4,Q9BUF5,Q9BVA1,Q8N4H5,P21796,Q9NS69,P68371 8 Autophagy 0.6041894996368226 2.7223047440221544 0.0064828330295032 0.9998107023835412 0.1640822169757951 35 Q8IWA4,Q9BUF5,O95140,Q9Y2Q5,Q9BVA1,Q13409,Q8WUX9,Q9Y4P1,Q8N4H5,P21796,Q6IAA8,Q99816,Q15388,P68371,Q9NS69,Q13501 16 Transport of small molecules 0.4651559809528418 2.693621266363267 0.0070680428540674 0.9999129265246636 0.1640822169757951 130 P30519,P28070,Q8TB61,P49721,Q9HD20,Q8WTV0,P08183,P07237,P21796,P09601,O15439,Q99436,Q15904,P45880,P61421,P28074,P61916,P28072,P63208,Q9H2J7,Q8N4V1,Q9Y277,Q93050,Q9C0H2,Q70HW3,O15118,Q9BUN8,P20618,P60900,P30626,Q9Y487,Q9UBX3,Q99797 33 Mitochondrial protein import 0.6150760864681395 2.6740118928242596 0.0074949793504839 0.9999506013735716 0.1640822169757951 32 O60830,O14925,Q99595,Q8N4H5,P21796,Q13505,Q9NS69 7 Nuclear envelope ne reassembly 0.5415880573963008 2.407065528652509 0.0160812840908772 0.9999999994748852 0.1825288189773744 41 Q9BUF5,Q8IXJ6,Q9BVA1,Q86XL3,Q8NFH4,P68371,P37198,Q9BTX1,Q14739 9 Mitophagy 0.7677635242315003 2.3942089130532023 0.0166562586002767 0.9999999997569688 0.1843201568329952 11 Q8N4H5,P21796,Q9NS69,Q13501 4 Protein localization 0.4706917124766949 2.344302370978532 0.0190627100851521 0.9999999999903804 0.2014246453483615 61 O60830,O14925,P05067,Q99595,O75874,P46379,Q9NX63,Q8N4H5,Q9NR77,P21796,P09601,Q15067,Q13505,O43681,Q9NS69 15 Pink1 prkn mediated mitophagy 0.795375647119218 2.338826795303603 0.0193443993580768 0.9999999999934118 0.2014246453483615 9 Q8N4H5,P21796,Q9NS69,Q13501 4 Cholesterol biosynthesis 0.7292770521494585 2.3218175660348557 0.0202427609890276 0.9999999999980314 0.2084371795588942 12 Q9UBM7,P48449,Q16850,Q14739 4 Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 0.4771078355567703 2.267006891123395 0.0233898047548124 0.9999999999999716 0.2335436565669909 52 O75880,O14949,P36542,Q9Y375,O75306,P31930,Q16134,O75947,Q8IUX1,P13804,O75964,P56134,P00403,P20674,O43676,Q9NPL8,Q9UDW1,P22695,P24539,Q9P032,Q8N183 21 The role of gtse1 in g2 m progression after g2 checkpoint 0.5071963359027455 2.251112004749717 0.0243784442713914 0.9999999999999926 0.2415848838322853 45 P28070,Q9BUF5,O75832,P28072,Q9BVA1,P49721,P20618,P60900,Q99436,P28074,P68371 11 Iron uptake and transport 0.6339271765867909 2.240533993887829 0.0250562764318746 0.999999999999997 0.2464490472926182 18 P30519,P09601,Q93050,Q9Y487,Q15904 5 Rho gtpases activate iqgaps 0.7839721840883651 2.2161588541983073 0.0266806246978883 0.9999999999999996 0.2523699839560633 8 Q9BUF5,P68371 2 Sealing of the nuclear envelope ne by escrt iii 0.8764496358578704 2.1596075321784305 0.0308030648397739 1.0 0.2688638374756424 6 Q9BUF5,P68371 2 Cytoprotection by hmox1 0.4529945738491909 2.155889353289775 0.0310923060170529 1.0 0.2696030219110247 59 P30519,P28070,P28072,P49721,P20618,P60900,P63208,P00403,P20674,P09601,Q99436,P28074 12 Carboxyterminal post translational modifications of tubulin 0.9259214820547425 2.13523523275018 0.0327418003230779 1.0 0.2721109695191203 4 Q9BUF5,P68371 2 Metabolism of cofactors 0.925560620388846 2.133817608146028 0.0328577139549826 1.0 0.2721109695191203 4 P00374,O75874 2 Signaling by interleukins 0.4161221556709102 2.1337988856395507 0.0328592471689819 1.0 0.2721109695191203 95 P28070,P49721,P07237,P09601,Q99436,Q13501,P05067,P11233,P62993,P28074,P52597,P28072,Q13126,P63208,P04083,P20618,P60900,P51809,P22626,Q14738,O14979,Q00169 22 Sphingolipid de novo biosynthesis 0.7613619165143617 2.114203127671482 0.034497921862018 1.0 0.2789463865898147 8 Q06136 1 Post chaperonin tubulin folding pathway 0.8627396957110018 2.104282731088308 0.0353537915234383 1.0 0.2834894961618263 6 Q9BUF5,P68371 2 Assembly and cell surface presentation of nmda receptors 0.7586216570094569 2.1017638809277037 0.035573964573925 1.0 0.2834894961618263 8 Q9BUF5,Q9BVA1,P68371 3 Synthesis of pe 0.9530995106035892 2.080772346376567 0.0374547484768443 1.0 0.2938414195981005 2 Q9UG56 1 Regulation of mrna stability by proteins that bind au rich elements 0.4461326130886716 2.0725473888357313 0.0382144216420448 1.0 0.2978798106288788 56 Q15024,Q01105,P28070,O75832,P04792,P28072,Q9Y2L1,P49721,P20618,P60900,Q99436,P28074,Q14103 13 Gpcr ligand binding 0.748143489989037 2.0540346061636505 0.0399723424250066 1.0 0.3067347612975619 8 P04083,Q9Y3E5,P05067,P42892 4 Metabolism of steroids 0.5198728417567869 2.0534482992097924 0.0400291190767683 1.0 0.3067347612975619 34 P48449,P04062,Q14849,Q16850,Q9UBM7,Q14739 6 Cellular response to chemical stress 0.436899718223053 2.0483806774659463 0.0405227133455081 1.0 0.3073763646960997 68 P30519,P28070,P28072,P49721,P20618,P60900,P63208,P07237,P00403,P20674,P09601,Q99436,P28074 13 Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.6923704283742009 2.0264356111248025 0.042720164772626 1.0 0.3181083455950348 11 P49069,P05067,P46379,P09601,O43681 5 Neutrophil degranulation 0.4163062988145258 2.00847150369389 0.0445932112454345 1.0 0.3301901821431617 144 P30519,Q9H7Z7,O95721,P42785,P06280,P16278,P61020,O75874,P07437,Q9BTY2,Q13510,Q99519,P68371,P61916,P10619,Q93050,P17900,P20618,P10253,O43681 20 Respiratory electron transport 0.4850138266993796 1.9970192581021615 0.0458230909991936 1.0 0.3355268552052071 43 Q8IUX1,O75306,P13804,Q8N183,Q9UDW1,P31930,Q16134,P22695,P00403,P20674,O75880,O43676,O14949,Q9P032,Q9Y375 15 Gap junction trafficking and regulation 0.734630763135221 1.992099900621296 0.0463600978759326 1.0 0.3375834751407692 8 Q9BUF5,P68371 2 Initiation of nuclear envelope ne reformation 0.6179848014921778 1.971115117979682 0.0487107098889605 1.0 0.348916932791576 15 Q86XL3,Q14739 2 Metabolism of porphyrins 0.8256453005536144 1.9529251384744424 0.0508284664558289 1.0 0.3598183316911669 6 P30519 1 Metabolism of folate and pterines 0.7260935531559786 1.9527496373436293 0.0508492688317139 1.0 0.3598183316911669 8 P00374,Q9H2D1 2 Organelle biogenesis and maintenance 0.4238772618516697 1.9493036466241045 0.0512591733625953 1.0 0.3598183316911669 73 Q15691,Q13409,O60645,P48735,A0AVF1,A6NIH7,P07437,P61163,Q13505,P68371,Q9BUF5,P18085,Q9BVA1,O75964,Q9NX63,Q9BW83,Q00059,O75431,Q92973,Q5XKP0,O75935 21 Sialic acid metabolism 0.8428715717359139 1.9301413820225968 0.053589322225787 1.0 0.3598183316911669 5 P10619,P16278 2 Regulation of runx3 expression and activity 0.4991735976566775 1.9285910786166636 0.0537816474530803 1.0 0.3598183316911669 35 P28070,P28072,P49721,P20618,P60900,Q99436,P28074 7 Gamma carboxylation hypusine formation and arylsulfatase activation 0.706304350793219 1.926258488515359 0.0540721059433144 1.0 0.3599345234004468 9 Q9HA64,P49366,Q9BQC3,O60725,O43681 5 Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.6078628113781149 1.9131163691560704 0.0557331566359986 1.0 0.361853696779538 15 Q02818,P05067,P07237,Q9BTY2,O43852 5 The nlrp3 inflammasome 0.8648497956915394 1.89254985944171 0.0584177571035997 1.0 0.3719546080316186 4 P09601 1 Purinergic signaling in leishmaniasis infection 0.8648497956915391 1.8925498594417067 0.0584177571036002 1.0 0.3719546080316186 4 P09601 1 Inflammasomes 0.8648497956915391 1.8925498594417067 0.0584177571036002 1.0 0.3719546080316186 4 P09601 1 Phase i functionalization of compounds 0.642300833567648 1.8749443319075176 0.0608003823317442 1.0 0.3809612021997119 12 P30837,P05091,Q5VT66,O43169,Q16850,P07099,Q15185 7 Signaling by hedgehog 0.4266289598170897 1.8685118616204448 0.0616907583394401 1.0 0.3809612021997119 54 P28070,Q9BUF5,P28072,Q9BVA1,P49721,P20618,P60900,P63208,P07237,Q96J02,Q99436,P28074,P68371 13 Negative regulation of notch4 signaling 0.4837728735628114 1.8619304996641877 0.062612887298141 1.0 0.3809612021997119 38 P28070,P28072,P49721,P20618,P60900,P63208,Q99436,P28074 8 Auf1 hnrnp d0 binds and destabilizes mrna 0.4751946264218293 1.858902743807184 0.0630409251228083 1.0 0.3809612021997119 41 P28070,P04792,P28072,P49721,P20618,P60900,Q99436,P28074,Q14103 9 Mitochondrial biogenesis 0.5234850467051749 1.8524637523612075 0.0639592579751107 1.0 0.3809612021997119 26 O75431,P36542,O75947,O75964,P56134,Q9NX63,P24539,Q5XKP0,P48735,Q00059,Q13505 11 Heme degradation 0.9724583984196932 1.8507714999923324 0.0642024328182171 1.0 0.3809612021997119 3 P30519 1 Gap junction assembly 0.9722562219502244 1.8500009811798488 0.0643134081741507 1.0 0.3809612021997119 3 Q9BUF5,P68371 2 Transport of connexons to the plasma membrane 0.9722562219502244 1.8500009811798488 0.0643134081741507 1.0 0.3809612021997119 3 Q9BUF5,P68371 2 Activation of ampk downstream of nmdars 0.9722562219502244 1.8500009811798488 0.0643134081741507 1.0 0.3809612021997119 3 Q9BUF5,P68371 2 Cyclin a cdk2 associated events at s phase entry 0.4740695157152956 1.849324842495366 0.0644109206628793 1.0 0.3809612021997119 41 P28070,P28072,P49721,P20618,P60900,P63208,P31751,Q99436,P28074 9 Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand 0.5211917601509661 1.8362140161972291 0.0663260105221077 1.0 0.3868039020714071 26 Q9BUF5,Q9BVA1,Q13409,P61163,O75935,P68371 6 Hedgehog off state 0.4478147970917663 1.8261163584445963 0.0678327366415671 1.0 0.3937239265462783 48 P28070,Q9BUF5,P28072,Q9BVA1,P49721,P20618,P60900,P63208,Q96J02,Q99436,P28074,P68371 12 The citric acid tca cycle and respiratory electron transport 0.4029053635977557 1.824277983838565 0.0681100570960178 1.0 0.3937239265462783 84 O75306,P13804,Q9UDW1,P31930,Q16134,O75964,P00403,P21796,P20674,O43676,Q15120,P48735,O14949,Q9Y375 14 Interleukin 1 signaling 0.4610258734002399 1.8169301078696096 0.069227815881526 1.0 0.3956671519416329 44 P28070,P28072,P05067,P49721,P20618,P60900,P63208,Q99436,P28074,Q13501 10 Signaling by notch4 0.4726099230214455 1.812898977473371 0.0698474039880072 1.0 0.3956671519416329 40 P28070,O75832,P28072,Q13573,P49721,P20618,Q92542,P60900,P63208,Q9UL46,Q99436,P28074 12 Glycosaminoglycan metabolism 0.6495986253498568 1.8106135515007704 0.0702006930061993 1.0 0.3956671519416329 11 O43505,Q8TB61,Q8NCH0,P54802,P16278,P15586 6 Class a 1 rhodopsin like receptors 0.7427768572288509 1.8102060832795552 0.0702638346018571 1.0 0.3956671519416329 7 P04083,P05067,P42892 3 Peptide ligand binding receptors 0.7427768572288509 1.8102060832795552 0.0702638346018571 1.0 0.3956671519416329 7 P04083,P05067,P42892 3 Mrna decay by 3 to 5 exoribonuclease 0.6295801763115362 1.807644572921652 0.070661836269084 1.0 0.3956671519416329 12 Q15024,Q9GZS3,Q9Y2L1,Q969T7,Q96C86,Q9Y3B2 6 Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways 0.785864315449778 1.7879903311863996 0.0737775677732699 1.0 0.4034806403534016 6 P05067,P09601 2 Cdt1 association with the cdc6 orc origin complex 0.4751635591979369 1.7713615363761548 0.0765006004718902 1.0 0.4079393641869078 37 Q9Y619,P28070,P28072,P49721,P20618,P60900,Q99436,P28074 8 Uch proteinases 0.4551115596062008 1.764385108404798 0.0776671636241923 1.0 0.4111057094646004 44 P85037,P28070,P28072,P49721,P20618,P60900,O96019,Q8NB78,Q99436,P28074 10 Antigen processing cross presentation 0.439659567549017 1.7497492192902475 0.080161596598683 1.0 0.4161865666217614 48 P28070,O75832,P28072,P49721,P20618,P60900,Q9UIQ6,Q99436,P28074 9 Interleukin 12 signaling 0.5019983646688797 1.7421089980875193 0.0814893733910073 1.0 0.4161865666217614 28 P52597,Q13126,P51809,P22626,P07237,P11233,P78417,O14979,Q00169 9 Irs mediated signalling 0.8723491027732468 1.7404230253244222 0.0817847653680072 1.0 0.4161865666217614 2 P31751 1 Insulin receptor signalling cascade 0.8723491027732468 1.7404230253244222 0.0817847653680072 1.0 0.4161865666217614 2 P31751 1 Signalling to ras 0.8723491027732444 1.7404230253244108 0.0817847653680092 1.0 0.4161865666217614 2 P11233 1 Slc mediated transmembrane transport 0.5661141184286013 1.7301641942150805 0.0836009435934428 1.0 0.4209532258505143 16 Q8TB61,P30626,Q9H2J7,P55011,Q9UBX3,Q70HW3 6 Rac2 gtpase cycle 0.5024395857179548 1.7229730376685188 0.0848934009537607 1.0 0.4254353705591508 27 Q86XL3,O15173,Q9UH62,Q13505,Q14739 5 Scf skp2 mediated degradation of p27 p21 0.4598309559994086 1.7042973468443776 0.0883255504003797 1.0 0.4300336586534078 40 P28070,P28072,P49721,P20618,P60900,P63208,Q99436,P28074 8 Runx1 regulates transcription of genes involved in differentiation of hscs 0.4566760349020988 1.677302418330899 0.0934833599224029 1.0 0.4384735529456481 40 P28070,P28072,P49721,P20618,P60900,Q03164,Q96J02,Q99436,P28074 9 Cristae formation 0.5413337929900055 1.673232288169315 0.0942815763718083 1.0 0.4390101769605474 18 P36542,O75947,O75964,P56134,Q9NX63,P24539,Q5XKP0,Q13505,O75431 9 Interconversion of nucleotide di and triphosphates 0.563930655492376 1.6570716528992058 0.0975049894448991 1.0 0.4424882401037752 15 Q9H773,P23919,P15531,P04818,P17812,P54819 6 Kinesins 0.5822597298085339 1.655567135410831 0.0978095102359415 1.0 0.4424882401037752 13 Q9BUF5,Q9BVA1,P68371 3 Translocation of slc2a4 glut4 to the plasma membrane 0.4956250963180169 1.6531339764121782 0.0983035998404546 1.0 0.4424882401037752 26 Q9BUF5,Q9BVA1,Q9UIQ6,P61106,P31751,O60645,P11233,P27348,P68371 9 Interleukin 1 family signaling 0.4392192062597166 1.649916101231316 0.098960097057573 1.0 0.4435238137741795 45 P28070,P28072,P05067,P49721,P20618,P60900,P63208,Q99436,P28074,Q13501 10 Diseases associated with glycosylation precursor biosynthesis 0.6612269192549458 1.6483968435662897 0.0992712633257837 1.0 0.4435238137741795 8 P10619,P16278 2 Signaling by the b cell receptor bcr 0.4529053398307095 1.6449449063869164 0.0999811730873549 1.0 0.4451864396254523 40 P28070,P28072,P49721,P20618,P60900,P63208,Q99436,P62993,P28074 9 Biological oxidations 0.4712019213180426 1.6402170862424192 0.1009600379354012 1.0 0.4480314141375717 33 P21964,Q8TB61,P30837,P05091,O14880,Q5VT66,O43169,O60701,O75223,Q16850,P78417,P07099,Q9NUJ1,Q15185 14 Intraflagellar transport 0.6572007345443599 1.6292105476547774 0.1032684548471956 1.0 0.4513957252191481 8 Q9BUF5,P68371,Q9BVA1,A0AVF1 4 Mitotic g2 g2 m phases 0.3948407547922049 1.6286137292831655 0.1033948160034556 1.0 0.4513957252191481 73 P28070,Q9BUF5,P28072,Q9BVA1,P49721,P20618,P60900,Q13409,P63208,P07437,P61163,O75935,Q99436,P28074,P68371 15 Egr2 and sox10 mediated initiation of schwann cell myelination 0.7697159042244854 1.6278351761842804 0.1035598395962686 1.0 0.4513957252191481 5 Q16850 1 Keratan sulfate keratin metabolism 0.769682389060704 1.6276950164537298 0.1035895703428591 1.0 0.4513957252191481 5 O43505,P16278 2 Mitotic g1 phase and g1 s transition 0.3996992824622336 1.6268306558991037 0.1037730688478011 1.0 0.4513957252191481 64 Q9Y619,P28070,P28072,P49721,P20618,P60900,P63208,P31751,P00374,Q99436,P35244,P28074 12 Aggrephagy 0.5944290910923916 1.619228585051656 0.1053980897817838 1.0 0.4554579748602989 12 Q9BUF5,P68371 2 Diseases of glycosylation 0.5656038232078135 1.611899536897882 0.1069838029975094 1.0 0.4592991841036747 14 O75340,P16278,P10619,Q99519 4 Beta oxidation of butanoyl coa to acetyl coa 0.793644395703129 1.6032272617108407 0.1088844887577902 1.0 0.4614862079440977 4 Q16836,P40939 2 Regulation of pten stability and activity 0.4503518135225565 1.602310040318675 0.1090870665358652 1.0 0.4614862079440977 39 P28070,P28072,P49721,P20618,P60900,P31751,Q99436,P28074 8 G1 s specific transcription 0.6510878933275539 1.6000196654355163 0.109594220854706 1.0 0.4614862079440977 8 P00374 1 Synthesis of substrates in n glycan biosythesis 0.5717690280462068 1.5964852891020889 0.1103804875976293 1.0 0.4633168237378198 13 P10619,P16278 2 Abc family proteins mediated transport 0.4266715041714302 1.5942776472958553 0.1108738618977416 1.0 0.4639103174007093 47 P28070,P28072,Q9BUN8,P49721,P20618,P60900,P08183,Q99436,P28074,O15439 10 Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation 0.9031380737702478 1.584548695039582 0.1130689095611638 1.0 0.4715975405114367 3 P00374 1 Mucopolysaccharidoses 0.7869387755102017 1.5756866581493534 0.1150980337072313 1.0 0.4740600263316592 4 P15586,P54802,P16278 3 Degradation of gli1 by the proteasome 0.4424215566414024 1.5544524010928764 0.1200765421542142 1.0 0.4862640645629325 40 P28070,P28072,P49721,P20618,P60900,P63208,Q96J02,Q99436,P28074 9 Mitochondrial calcium ion transport 0.5548254557871203 1.549410569333299 0.1212830546127381 1.0 0.4862640645629325 14 P21796 1 Signaling by fgfr 0.5542053756971682 1.545804861047485 0.1221517027054421 1.0 0.4862640645629325 14 P52597,P31943,Q01085,P62993,P31483,P19388 6 Signaling by fgfr2 0.5542053756971682 1.545804861047485 0.1221517027054421 1.0 0.4862640645629325 14 P52597,P31943,Q01085,P62993,P31483,P19388 6 Regulation of hmox1 expression and activity 0.4307994856264715 1.5454911220061271 0.1222275146877496 1.0 0.4862640645629325 44 P28070,P28072,P49721,P20618,P60900,P63208,P09601,Q99436,P28074 9 Cross presentation of soluble exogenous antigens endosomes 0.4495578781575782 1.542645903788448 0.1229167139083395 1.0 0.4862640645629325 36 P28070,P28072,P49721,P20618,P60900,Q99436,P28074 7 Degradation of axin 0.4495578781575782 1.542645903788448 0.1229167139083395 1.0 0.4862640645629325 36 P28070,P28072,P49721,P20618,P60900,Q99436,P28074 7 Hedgehog on state 0.4403702757791169 1.536657224506875 0.1243772712832411 1.0 0.4862640645629325 40 P28070,P28072,P49721,P20618,P60900,Q96J02,Q99436,P28074 8 Tristetraprolin ttp zfp36 binds and destabilizes mrna 0.6377836667705102 1.536242958388133 0.1244788036651862 1.0 0.4862640645629325 8 Q15024,Q92973,Q9Y3B2,Q9Y2L1 4 Signaling by erbb4 0.6795217998884238 1.5272940509426982 0.126687908133507 1.0 0.491101949764595 7 Q92542,P62993,Q96J02 3 Formyl peptide receptors bind formyl peptides and many other ligands 0.8867708539260755 1.5212172634924643 0.128205324615223 1.0 0.4955267385421231 3 P05067 1 Defective cftr causes cystic fibrosis 0.4382216226769579 1.5179866119802583 0.1290177737383477 1.0 0.4957592588546425 40 P28070,P28072,Q9BUN8,P49721,P20618,P60900,Q99436,P28074 8 Abc transporter disorders 0.4382216226769579 1.5179866119802583 0.1290177737383477 1.0 0.4957592588546425 40 P28070,P28072,Q9BUN8,P49721,P20618,P60900,Q99436,P28074 8 Switching of origins to a post replicative state 0.3923786412747579 1.5148910503378792 0.1297999971858507 1.0 0.4973151054969515 54 Q9Y619,P28070,P28072,P49721,Q96DE5,P20618,P60900,P63208,Q16763,Q99436,P28074 11 Rac3 gtpase cycle 0.4831932139090512 1.5024113791050098 0.1329908994012851 1.0 0.5063325969302183 24 Q14739 1 Activation of bad and translocation to mitochondria 0.6303363632293295 1.5004034423064048 0.1335099284006733 1.0 0.5063325969302183 8 P61981,P31751,P27348,Q04917 4 Downstream signaling events of b cell receptor bcr 0.4403461957908564 1.4982264992780563 0.1340744129959379 1.0 0.5063325969302183 38 P28070,P28072,P49721,P20618,P60900,P63208,Q99436,P28074 8 Neurotransmitter clearance 0.8144371941272437 1.4927358219639473 0.1355063525687498 1.0 0.5078730383903669 2 P21964 1 Biosynthesis of specialized proresolving mediators spms 0.8136215334420772 1.4892359629545089 0.1364252438088713 1.0 0.5078730383903669 2 Q14914 1 Synthesis of leukotrienes lt and eoxins ex 0.8136215334420772 1.4892359629545089 0.1364252438088713 1.0 0.5078730383903669 2 Q14914 1 Fc epsilon receptor fceri signaling 0.4243768406493928 1.4869121180912608 0.1370380232734798 1.0 0.5078730383903669 44 P28070,O75832,P28072,P49721,P20618,P60900,P63208,Q99436,P62993,P28074 10 Metabolism of polyamines 0.4409114079984866 1.4860935468290593 0.1372543789714373 1.0 0.5078730383903669 37 P28070,P28072,P49721,P20618,P60900,Q99436,P28074 7 Asymmetric localization of pcp proteins 0.439660067098418 1.4755270606685735 0.1400708985422538 1.0 0.5097435813972832 37 P28070,P28072,P49721,P20618,P60900,Q99436,P28074 7 Recruitment of numa to mitotic centrosomes 0.4652639315350108 1.4688641904385007 0.1418696291242851 1.0 0.5097435813972832 28 Q9BUF5,Q9BVA1,P07437,P61163,O75935,P68371 6 Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 0.5407859335353216 1.4674978541116013 0.142240672585894 1.0 0.5097435813972832 14 P10619,P16278,Q99519 3 Deadenylation dependent mrna decay 0.4528635413882227 1.466486347916922 0.1425158377640223 1.0 0.5097435813972832 32 Q9H9A5,Q15024,Q9GZS3,Q92600,Q9Y2L1,Q9UIV1,Q969T7,Q9NQT5,Q96C86,P62312,Q9Y3B2 11 Miro gtpase cycle 0.7598526971971389 1.464046468619551 0.1431812521324591 1.0 0.5097435813972832 4 Q8IWA4 1 Regulation of localization of foxo transcription factors 0.7093012999252557 1.4638315253269456 0.1432399864507179 1.0 0.5097435813972832 6 P31751,P27348 2 Regulation of ras by gaps 0.4381698766031217 1.462931062482184 0.143486243321997 1.0 0.5097435813972832 37 P28070,P28072,P49721,P20618,P60900,Q99436,P28074 7 Degradation of dvl 0.4381698766031217 1.462931062482184 0.143486243321997 1.0 0.5097435813972832 37 P28070,P28072,P49721,P20618,P60900,Q99436,P28074 7 Tnfr2 non canonical nf kb pathway 0.4311990402691236 1.4567487948188798 0.145185735147215 1.0 0.511668054112106 40 P28070,P28072,P49721,P20618,P60900,P63208,Q99436,P28074 8 Dectin 1 mediated noncanonical nf kb signaling 0.4311990402691237 1.4567487948188798 0.145185735147215 1.0 0.511668054112106 40 P28070,P28072,P49721,P20618,P60900,P63208,Q99436,P28074 8 Beta oxidation of hexanoyl coa to butanoyl coa 0.7284429359805323 1.4543010172745832 0.1458628685596235 1.0 0.5117315154889494 5 Q16836,P40939 2 Rhoa gtpase cycle 0.4400977308134199 1.4496353156231816 0.1471602424083609 1.0 0.5144753302233943 35 P30519,Q15904,Q14739 3 Hedgehog ligand biogenesis 0.4296193992988844 1.4429295066182122 0.1490403301614919 1.0 0.517036026731959 40 P28070,P28072,P49721,P20618,P60900,P07237,Q99436,P28074 8 Adora2b mediated anti inflammatory cytokines production 0.7042227950591013 1.4420711674452542 0.1492822978980397 1.0 0.517036026731959 6 P04899,P08754,Q9Y3E5,P10644 4 Synthesis of dna 0.3793220443861023 1.4403083869674496 0.1497801696203939 1.0 0.517036026731959 71 Q9Y619,P41440,P28070,P28072,P49721,Q96DE5,P20618,P60900,P63208,P35250,Q16763,Q99436,Q9BRT9,P35244,P28074 15 Nrif signals cell death from the nucleus 0.8013866231647531 1.4367244072457288 0.1507963169462289 1.0 0.517036026731959 2 Q13501 1 Transport of inorganic cations anions and amino acids oligopeptides 0.6594672904696586 1.4362926728786851 0.1509190781174934 1.0 0.517036026731959 7 P30626,Q9H2J7,Q9UBX3,Q70HW3 4 Signaling by insulin receptor 0.5774933319580285 1.4358992592174598 0.1510310093261033 1.0 0.517036026731959 11 P61421,P31751,Q93050,Q9Y487,Q15904 5 Formation of tubulin folding intermediates by cct tric 0.5770295233741582 1.4334501955460266 0.1517292223029951 1.0 0.5180806087962372 11 Q9BUF5,P68371 2 Signaling by type 1 insulin like growth factor 1 receptor igf1r 0.863600256537606 1.431380401732114 0.1523212221140448 1.0 0.5187580639439564 3 P31751 1 Transcriptional regulation by runx2 0.4150200107487478 1.4268787305855264 0.1536148525574314 1.0 0.5218154012131305 45 P28070,P28072,P49721,P20618,P60900,P63208,P31751,Q99436,P28074,Q96PK6 10 Ksrp khsrp binds and destabilizes mrna 0.6029329014340844 1.4238845610254265 0.1544798917466159 1.0 0.5234048774345496 9 Q15024,Q92945,Q9NQT5,Q9Y2L1,Q9Y3B2 5 Stabilization of p53 0.4328844213358963 1.4181461128864508 0.1561481107072226 1.0 0.5263509204913542 37 P28070,P28072,P49721,P20618,P60900,Q99436,P28074 7 Interleukin 12 family signaling 0.4525407257064078 1.4147155770044724 0.1571519053430123 1.0 0.5268217818282318 30 P52597,Q13126,P51809,P22626,P07237,P11233,P78417,O14979,Q00169 9 Fceri mediated nf kb activation 0.4261921863502991 1.41289193215793 0.1576875016388497 1.0 0.5268217818282318 40 P28070,O75832,P28072,P49721,P20618,P60900,P63208,Q99436,P28074 9 Apoptotic factor mediated response 0.795676998368667 1.412215053680839 0.1578866493339541 1.0 0.5268217818282318 2 Q9NR28 1 Copi independent golgi to er retrograde traffic 0.4807558211086847 1.4082243907564809 0.1590646360806891 1.0 0.5280785651243028 22 Q9BUF5,Q9BVA1,Q13409,P61163,O75935,P68371 6 Clec7a dectin 1 signaling 0.4167851194397178 1.3930188268922528 0.1636140975671498 1.0 0.5391520977492418 43 P28070,O75832,P28072,P49721,P20618,P60900,P63208,Q99436,P28074 9 Orc1 removal from chromatin 0.4054770461803641 1.3929750229804596 0.163627343778222 1.0 0.5391520977492418 47 Q9Y619,P28070,P28072,P49721,P20618,P60900,P63208,Q99436,P28074 9 Response to elevated platelet cytosolic ca2 0.461923184473284 1.3905184047267831 0.164371514456447 1.0 0.5402535063680728 25 P07737,P05067,Q8NBX0,O15439,O43852,Q08380 6 Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 0.410438172735878 1.3841602878659665 0.166309380163546 1.0 0.5449355032415709 45 P28070,P28072,P49721,Q96DE5,P20618,P60900,Q16763,Q99436,P28074 9 Gene and protein expression by jak stat signaling after interleukin 12 stimulation 0.4584504727433218 1.3809678147281084 0.1672888569426232 1.0 0.5457591917088549 26 P52597,Q13126,P22626,P11233,P78417,O14979,Q00169 7 Cooperation of prefoldin and tric cct in actin and tubulin folding 0.5170265826812676 1.3765544070448597 0.1686500552041647 1.0 0.5477218292233211 15 Q9BUF5,P68371 2 G1 s dna damage checkpoints 0.4259592074700865 1.3749815466163813 0.1691371657768525 1.0 0.5477218292233211 38 P28070,P28072,P49721,P20618,P60900,Q99436,P28074 7 Signaling by notch 0.3901364796905253 1.3725816303420892 0.1698824458343764 1.0 0.5487869206120296 51 P28070,O75832,P28072,Q13573,P49721,P20618,Q92542,P60900,P63208,Q9UL46,Q96J02,Q99436,P28074,Q9UBV2 14 Translesion synthesis by polk 0.5900893591835995 1.3600117052776437 0.1738262197934506 1.0 0.557408257604384 9 P41440,P35250 2 Insulin receptor recycling 0.5898253045347839 1.3586959832160277 0.1742429454726906 1.0 0.557408257604384 9 Q93050,Q9Y487,Q15904 3 Transcriptional regulation by runx3 0.4202463026151529 1.342419171005913 0.1794601221542007 1.0 0.5678251015246967 39 P28070,O75832,P28072,Q13573,P49721,P20618,P60900,Q99436,P28074 9 Cilium assembly 0.3997108776660872 1.3376182963625092 0.1810208970512872 1.0 0.5678251015246967 47 Q9BUF5,Q15691,P18085,Q9BVA1,Q9BW83,Q13409,Q92973,P07437,P61163,O75935,A0AVF1,A6NIH7,P68371 13 Adenylate cyclase inhibitory pathway 0.7777324632952722 1.335210595282506 0.1818074300784689 1.0 0.5678251015246967 2 P04899 1 G alpha z signalling events 0.7777324632952722 1.335210595282506 0.1818074300784689 1.0 0.5678251015246967 2 P04899 1 Gaba b receptor activation 0.7777324632952722 1.335210595282506 0.1818074300784689 1.0 0.5678251015246967 2 P04899 1 Adp signalling through p2y purinoceptor 12 0.7777324632952722 1.335210595282506 0.1818074300784689 1.0 0.5678251015246967 2 P04899 1 Tcr signaling 0.4099843568935282 1.3309551810210976 0.183203758668581 1.0 0.5693188289281057 43 P28070,O75832,P28072,P49721,P20618,P60900,P63208,Q99436,P28074 9 C type lectin receptors clrs 0.4046271969735107 1.3297735041291656 0.1835929082717502 1.0 0.5693188289281057 45 P28070,O75832,P28072,P49721,P20618,P60900,P63208,Q99436,P28074 9 Dna replication pre initiation 0.3785521613563039 1.328357174661424 0.1840601399788202 1.0 0.5693188289281057 53 Q9Y619,P28070,P28072,P49721,P20618,P60900,Q99436,P35244,P28074 9 Mapk6 mapk4 signaling 0.3986250262646402 1.3271673732462537 0.1844533225487248 1.0 0.5693188289281057 47 P28070,P04792,P28072,P49721,P20618,P60900,Q99436,P28074 8 Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex 0.5943264232929587 1.3258860795685503 0.1848774345836337 1.0 0.5693188289281057 8 Q9Y3B8,Q04917,P06493,P62258,P61981,P27348 6 Recycling pathway of l1 0.4986253516178517 1.3160105243009286 0.1881705103287108 1.0 0.5764841771054924 16 Q9BUF5,P68371 2 Fgfr2 alternative splicing 0.5380719736313622 1.31050752512544 0.1900242001986556 1.0 0.5764841771054924 12 P52597,P31943,Q01085,P31483,P19388 5 Flt3 signaling 0.8314432864844534 1.3065722776610884 0.1913580169071145 1.0 0.5764841771054924 3 P31751 1 Regulated proteolysis of p75ntr 0.7703915171288749 1.3037368212348557 0.1923233303734155 1.0 0.5764841771054924 2 Q92542 1 Activation of nmda receptors and postsynaptic events 0.5047969465434192 1.302382337493933 0.1927857173835656 1.0 0.5764841771054924 15 Q9BUF5,Q9BVA1,P68371 3 Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 0.5775357379806114 1.297358883754008 0.1945077326361879 1.0 0.5764841771054924 9 Q9H9A5,Q92600,Q9UIV1 3 Pcp ce pathway 0.4011261560987246 1.2968978469215229 0.1946663374391213 1.0 0.5764841771054924 45 P28070,P07737,P28072,P49721,P20618,P60900,Q99436,P28074 8 Copi mediated anterograde transport 0.4104108062829305 1.292482797854756 0.1961899994100053 1.0 0.5764841771054924 41 Q9BUF5,Q9BVA1,Q13409,P62820,P61923,P61163,O75935,P24390,P68371 9 Plasma lipoprotein assembly 0.7671288743882516 1.2897568705504454 0.1971350869754975 1.0 0.5764841771054924 2 P07237 1 Costimulation by the cd28 family 0.575632352633346 1.2878427198056877 0.1978007180801539 1.0 0.5767728903310685 9 P31751,Q14738 2 Deubiquitination 0.3612629314661017 1.264851689346162 0.2059244981196595 1.0 0.5824216491882216 76 P45880,P85037,P28070,P28072,P49721,P20618,Q9NXR7,P60900,O96019,Q8NB78,P21796,Q9Y277,Q99436,P28074 14 Beta oxidation of lauroyl coa to decanoyl coa coa 0.7105535291101744 1.2597998413236415 0.2077415770545907 1.0 0.5837160066994499 4 Q16836 1 Negative regulation of the pi3k akt network 0.661684456024624 1.2589716203299983 0.2080405827058991 1.0 0.5837160066994499 6 P31751,Q14738 2 Dna replication 0.3605483231769574 1.2498182125635378 0.2113659614968568 1.0 0.5902125789255451 75 Q9Y619,P41440,P28070,P28072,P49721,Q96DE5,P20618,P60900,P63208,P35250,Q16763,Q99436,Q9BRT9,P35244,P28074 15 Transferrin endocytosis and recycling 0.5417414071002763 1.2460063575401823 0.2127620611723557 1.0 0.5928549611525684 11 Q93050,Q9Y487,Q15904 3 Butyrate response factor 1 brf1 binds and destabilizes mrna 0.6157557872312931 1.2364191797467214 0.2163027904210996 1.0 0.5975337869097194 7 Q15024,Q9Y3B2,Q9Y2L1,Q9NQT5 4 Ctla4 inhibitory signaling 0.8133243898048134 1.2363219749755547 0.2163389059285232 1.0 0.5975337869097194 3 Q14738 1 Activation of gene expression by srebf srebp 0.506903809274691 1.224774726894712 0.2206601097661882 1.0 0.6044579397165353 13 P48449,Q16850 2 Cellular response to hypoxia 0.4065622795799651 1.2224920320941053 0.22152161521929 1.0 0.6044579397165353 39 P28070,P28072,P49721,P20618,P60900,Q99436,P28074 7 Tp53 regulates transcription of cell cycle genes 0.4914921234100527 1.2213041110799985 0.2219708974376351 1.0 0.6044579397165353 15 Q9H9A5,Q92600,Q9UIV1 3 Synaptic adhesion like molecules 0.6729075248767409 1.2187954968128183 0.222921821118891 1.0 0.6050436053998419 5 O95197 1 Aquaporin mediated transport 0.700552003644253 1.2183155286565388 0.2231040912172406 1.0 0.6050436053998419 4 Q99797,P10644 2 Atf4 activates genes in response to endoplasmic reticulum stress 0.5601471192976013 1.2102889695047552 0.2261680288048326 1.0 0.6051963870136237 9 Q15024,Q92945,Q9NQT5,Q9Y2L1,Q9Y3B2 5 Glucuronidation 0.8064613745864434 1.209750428931039 0.2263746728359001 1.0 0.6051963870136237 3 Q9NUJ1 1 Ion channel transport 0.4418005783711198 1.204385182118446 0.2284407365946168 1.0 0.6094835846795648 24 P61421,P30626,Q93050,Q9Y487,Q15904,Q9C0H2 6 Wnt ligand biogenesis and trafficking 0.6936921396314761 1.1898745251231488 0.2340957124989275 1.0 0.6183129239951634 4 O60493 1 Deadenylation of mrna 0.4861533322806265 1.1886739623097466 0.2345679904992093 1.0 0.6183212229559156 15 Q9H9A5,Q92600,Q9UIV1 3 Metabolism of steroid hormones 0.8001260217413965 1.1852473953465408 0.2359196456720815 1.0 0.6194065597525966 3 Q14849 1 Extra nuclear estrogen signaling 0.599127799327684 1.1600625757003071 0.2460233297829801 1.0 0.6328668852180371 7 P04899,P31751,P04792 3 Nuclear signaling by erbb4 0.6861728761531789 1.158719951104145 0.2465703557393446 1.0 0.6328668852180371 4 Q92542 1 Mitotic metaphase and anaphase 0.3382011698238639 1.158136144782925 0.2468084817921632 1.0 0.6328668852180371 117 P28070,P49721,Q86XL3,Q13409,Q99436,P37198,Q14739,Q8IXJ6,Q8NFH4,P68371,Q9BUF5,P28072,Q9BVA1,Q96DE5,P20618,P60900,Q14738,Q16763,Q9BTX1 19 Beta catenin independent wnt signaling 0.3809899609356952 1.1563565266674334 0.2475353558519373 1.0 0.6334982505103949 47 P28070,P07737,P28072,P49721,P20618,P60900,Q99436,P28074 8 O linked glycosylation 0.7915261462618517 1.1520335231951355 0.2493072980589852 1.0 0.6355648333495987 3 Q10472 1 O linked glycosylation of mucins 0.7915261462618517 1.1520335231951355 0.2493072980589852 1.0 0.6355648333495987 3 Q10472 1 Mitochondrial fatty acid beta oxidation of saturated fatty acids 0.5960825656118913 1.1460725904611395 0.251765117684239 1.0 0.6405915542622144 7 Q16836,P40939 2 Degradation of beta catenin by the destruction complex 0.381455771352041 1.1349602130362832 0.2563919891666271 1.0 0.6463412054888908 46 P28070,P28072,P49721,P20618,P60900,P63208,Q14738,Q99436,P28074 9 Hs gag degradation 0.786617707058352 1.133105145103941 0.2571701009741707 1.0 0.6463412054888908 3 P54802,P16278 2 Heparan sulfate heparin hs gag metabolism 0.786617707058352 1.133105145103941 0.2571701009741707 1.0 0.6463412054888908 3 P54802,P16278 2 Intra golgi traffic 0.5930492261735465 1.1321371028305425 0.2575767982482513 1.0 0.6463412054888908 7 O00461 1 Regulation of runx2 expression and activity 0.3923652967872599 1.1299560355897096 0.2584947502722821 1.0 0.6463412054888908 41 P28070,P28072,P49721,P20618,P60900,P63208,Q99436,P28074 8 Extracellular matrix organization 0.4304566362717023 1.1216717233973008 0.2620020435552712 1.0 0.6503176900298446 24 O15460,P05067,Q92542,O75718,Q32P28,Q03001,P07237,P13674 8 Protein protein interactions at synapses 0.5305497652408006 1.1126445994456595 0.2658610977576345 1.0 0.6574201254119368 10 Q14168,O95197 2 Signaling by nuclear receptors 0.3899994935363752 1.1085333524023202 0.2676315433718992 1.0 0.6585339809362575 41 P04792,O94788,Q08752,P31751,Q8NB78,Q8NBN7,Q15120,P19388 8 Diseases of carbohydrate metabolism 0.5498030298272513 1.1082388481066028 0.2677586774628893 1.0 0.6585339809362575 8 P15586,P54802,P10253,P16278 4 Ub specific processing proteases 0.3526012404844825 1.101807002814029 0.2705455852867267 1.0 0.6595405602523104 62 P45880,P28072,P20618,P49721,P21796 5 Gaba receptor activation 0.7780497756018002 1.100123020582604 0.2712785249159444 1.0 0.6595405602523104 3 P04899,Q9Y639 2 G alpha s signalling events 0.7780497756017962 1.100123020582588 0.2712785249159513 1.0 0.6595405602523104 3 P04899,Q9Y3E5 2 G2 m checkpoints 0.3481070409788076 1.0980433769181854 0.2721855486240261 1.0 0.6595405602523104 74 Q9Y619,P28070,P28072,P49721,P20618,Q9NXR7,P60900,O96028,P35250,Q99436,P35244,Q9UQ84 12 S phase 0.3437098024644901 1.0914576626808676 0.2750715514782231 1.0 0.6598260634641896 81 Q9Y619,P41440,P28070,P28072,P20618,P49721,Q96DE5,P60900,P63208,P35250,Q16763,P31751,Q99436,Q9BRT9,P35244,P28074 16 Cdc42 gtpase cycle 0.4334477408136626 1.077224298623888 0.2813800723581763 1.0 0.6676847744504973 22 Q14739 1 Leishmania infection 0.4174593350384861 1.0741252235661207 0.2827665608874592 1.0 0.6676847744504973 26 P08754,P05067,Q9UQB8,P78536,P09601,P10644,P04899,P62993,Q9Y3E5 9 Activated notch1 transmits signal to the nucleus 0.770705834353328 1.071920118276924 0.2837559130907185 1.0 0.6678398097385126 3 Q92542,Q96J02 2 Apc c mediated degradation of cell cycle proteins 0.3601916118033547 1.0654260243860991 0.2866831851804459 1.0 0.6723281816153517 51 P28070,P28072,P49721,Q96DE5,P20618,P60900,P63208,Q16763,Q99436,P28074 10 Translation of replicase and assembly of the replication transcription complex 0.7141109298531847 1.064030147362307 0.2873150426825583 1.0 0.6726131905073035 2 Q8WUX9 1 Innate immune system 0.3725552189897549 1.0596562130988578 0.2893010299858698 1.0 0.6737346855893396 229 P30519,P28070,Q9H7Z7,P49721,P42785,O95721,P06280,P16278,P09601,P61421,P05067,P61020,Q8IV08,O75874,P07437,Q9BTY2,Q13510,P68371,Q99519,P61916,O00584,P28072,Q9UQB8,P10619,Q93050,P17900,P11279,P20618,P60900,Q9Y487,P10253,O43681 32 Complex i biogenesis 0.4305395954293891 1.0566932769467638 0.2906515943000485 1.0 0.6737346855893396 22 Q8IUX1,O75306,Q8N183,Q9NPL8,O43676,Q9P032,Q9Y375 7 Collagen biosynthesis and modifying enzymes 0.5057084508112548 1.0531067583657734 0.2922920657361734 1.0 0.6737346855893396 11 O75718,O15460,P13674 3 G alpha i signalling events 0.4451063857126948 1.0492761164473867 0.2940510550390618 1.0 0.6737346855893396 18 P08754,P05067,Q14738,P04083,Q9ULM6,P10644,P04899 7 Transport of vitamins nucleosides and related molecules 0.5749217456041295 1.0488973121489138 0.2942253827440217 1.0 0.6737346855893396 7 P12236,P12235,Q8TB61 3 Anti inflammatory response favouring leishmania parasite infection 0.5271324743886833 1.044511346744622 0.2962488722708258 1.0 0.6737346855893396 9 P08754,P78536,P10644,P04899,Q9Y3E5 5 Ptk6 regulates proteins involved in rna processing 0.7084013050570973 1.039975017343152 0.2983515076054592 1.0 0.6737346855893396 2 P23246 1 Hcmv early events 0.3865567467244188 1.0318080775730687 0.3021620344955302 1.0 0.6761452656453462 38 Q9BUF5,Q9BVA1,Q13409,P83916,P37198,Q9BTX1,P68371 7 Ros and rns production in phagocytes 0.5333860978498643 1.0278581921675511 0.3040165381918593 1.0 0.6779928888948742 8 Q93050,Q9Y487 2 Class i peroxisomal membrane protein import 0.6068431741448876 1.0222256845722146 0.3066740970222601 1.0 0.6827642903299642 6 P51648,Q9NR77 2 L1cam interactions 0.4080661732426648 1.0163787988318729 0.3094490376188084 1.0 0.6851700337149833 27 Q9BUF5,P68371 2 Intra golgi and retrograde golgi to er traffic 0.3436787094275522 1.0123020295001943 0.3113936647915591 1.0 0.6851700337149833 66 Q9BUF5,P18085,Q9BVA1,O95721,Q9NSK0,Q13409,O00461,P62820,P61923,Q10472,P61163,O75935,P24390,P68371 14 Hcmv infection 0.3751941179366644 0.9909512716228508 0.321709374753214 1.0 0.7023791787273223 42 Q9BUF5,Q9BVA1,Q13409,Q8NFH4,Q99816,P83916,P37198,Q9BTX1,P68371 9 Tcf dependent signaling in response to wnt 0.3430654678213638 0.9868685144728504 0.3237071012372836 1.0 0.7040362366843892 54 P28070,P28072,P49721,P20618,P60900,Q14738,P31751,Q99436,P28074 9 Hiv transcription initiation 0.5244753567307675 0.984286449498122 0.3249746901593582 1.0 0.7053827522750429 8 P18074,Q92804,P19388 3 Glycerophospholipid biosynthesis 0.4327143167933848 0.9674226563744496 0.3333327885222772 1.0 0.7162103273071841 18 P35790,P40939,Q9UG56 3 Collagen formation 0.4625370091997353 0.9665880591242884 0.333750006259804 1.0 0.7162103273071841 13 O75718,O15460,P13674 3 Pyruvate metabolism 0.4479928597133632 0.954513606396052 0.3398237252558784 1.0 0.7229775386159452 15 P21796 1 Mapk family signaling cascades 0.3350032762504415 0.9539762677015108 0.3400956554946024 1.0 0.7229775386159452 76 P28070,P04792,P28072,P49721,P20618,P60900,Q14738,Q99436,P62993,O60725,Q14168 11 Hdr through single strand annealing ssa 0.472822792394591 0.9469766445656695 0.3436506802017334 1.0 0.7281858464724833 12 Q9UQ84,P35250 2 Regulation of cholesterol biosynthesis by srebp srebf 0.4244299452022591 0.934766378063634 0.3499087102602642 1.0 0.7349836967695952 19 P48449,Q16850 2 Regulation of beta cell development 0.7330245362756858 0.9285445919641232 0.3531251480890138 1.0 0.7370402442080761 3 P31751 1 Transcriptional regulation by runx1 0.3368050539582568 0.9207491325642828 0.3571814179836861 1.0 0.7370402442080761 59 P28070,P28072,P49721,P20618,P60900,O96019,Q03164,Q969G3,Q96J02,Q99436,P28074 11 Signalling to erks 0.6022133439958711 0.919851279241766 0.3576504819391426 1.0 0.7370402442080761 5 P11233 1 Copi dependent golgi to er retrograde traffic 0.3756504170624443 0.914243992064491 0.3605886529701143 1.0 0.7370402442080761 36 Q9BUF5,P24390,Q9BVA1,P68371 4 Formation of atp by chemiosmotic coupling 0.500839838204431 0.9127283062219252 0.3613854527866666 1.0 0.7370402442080761 9 P24539,O75947,P56134,O75964 4 Tysnd1 cleaves peroxisomal proteins 0.6241626868413859 0.9039318016149208 0.3660315649628665 1.0 0.7388016284278744 4 Q15067 1 Chondroitin sulfate dermatan sulfate metabolism 0.7263100888632706 0.9032967884469558 0.366368400564657 1.0 0.7388016284278744 3 Q8NCH0 1 Diseases associated with glycosaminoglycan metabolism 0.7263100888632706 0.9032967884469558 0.366368400564657 1.0 0.7388016284278744 3 Q8NCH0 1 Fatty acid metabolism 0.3632481774725895 0.8979319202518906 0.3692218458077332 1.0 0.7394053582892388 43 O43772,Q9H7Z7,P23786,Q15165,P50897,Q16836,P16219,P40939,Q14914 9 Perk regulates gene expression 0.4761573607739074 0.8949138009164278 0.3708331686795267 1.0 0.7400718221700635 11 Q15024,Q92945,Q9NQT5,Q9Y2L1,Q9Y3B2 5 Asparagine n linked glycosylation 0.3216578008411496 0.8922903131578502 0.3722373450384366 1.0 0.7400718221700635 90 Q99519,Q9BUF5,O75340,Q9BVA1,Q9BUN8,Q13409,P62820,P10619,P61923,P16278,P61163,O75935,P24390,P68371 14 Signaling by retinoic acid 0.4957422167631187 0.8872762553431873 0.3749301861539424 1.0 0.7428532459205526 9 O94788,Q15120 2 Formation of the cornified envelope 0.6195918367346903 0.8854098985388368 0.3759355956214025 1.0 0.7428532459205526 4 Q14126,P15924,P14923 3 Keratinization 0.6195918367346903 0.8854098985388368 0.3759355956214025 1.0 0.7428532459205526 4 Q14126,P15924,P14923 3 Anchoring of the basal body to the plasma membrane 0.3928863622513057 0.8777440355465498 0.3800826414076823 1.0 0.747684957276605 25 P61163,O75935,P07437,P68371 4 Mhc class ii antigen presentation 0.3599274186269269 0.8668961292274967 0.3859989245699613 1.0 0.7498338673409787 43 Q9BUF5,Q9BVA1,Q9NSK0,P10619,P61163,O75935,P68371 7 Circadian clock 0.5694366812265123 0.8621131846768633 0.3886252366921368 1.0 0.753247149941524 6 P43490,P63208 2 Synthesis secretion and deacylation of ghrelin 0.7118221144698362 0.849215290346684 0.3957615065785496 1.0 0.7592629776863586 3 P67812 1 Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip 0.7118221144698362 0.849215290346684 0.3957615065785496 1.0 0.7592629776863586 3 P67812 1 Rhog gtpase cycle 0.3804958974560218 0.8458874323496358 0.3976155441188584 1.0 0.7606056417251894 30 Q14739 1 Fcgr3a mediated il10 synthesis 0.6073108987148642 0.8359140397303763 0.4032032634798488 1.0 0.7657376098940069 4 P10644 1 Cargo recognition for clathrin mediated endocytosis 0.3949976260934871 0.8323303271751353 0.4052225169336174 1.0 0.7684651472208746 23 Q14108,Q8NC96,Q99627,P51809,P62993,Q9NVZ3 6 Platelet homeostasis 0.5616568572583582 0.8291417823052145 0.4070241832695651 1.0 0.7706383627644703 6 P30626 1 Separation of sister chromatids 0.3164592848870311 0.8165518090540048 0.414184604522672 1.0 0.7743195868948678 89 Q9BUF5,P28070,P28072,Q9BVA1,P49721,P20618,Q96DE5,P60900,Q13409,Q8NFH4,Q14738,Q16763,Q99436,P68371 14 Golgi to er retrograde transport 0.3256491250404781 0.7964283233576072 0.4257831211273661 1.0 0.7848082961015235 55 Q9BUF5,P18085,Q9BVA1,Q9NSK0,Q13409,P62820,P61923,P61163,O75935,P24390,P68371 11 Homologous dna pairing and strand exchange 0.4325319534995443 0.7923933004567556 0.4281313845955958 1.0 0.7848082961015235 13 Q9UQ84,P35250 2 Regulation of plk1 activity at g2 m transition 0.3800332106004766 0.7909423465858779 0.4289776356788837 1.0 0.7849311400930012 26 P63208,Q13409,P07437,P61163,O75935,P68371 6 Signaling by notch3 0.6943652711187154 0.7848882536087521 0.4325190896766591 1.0 0.7884649518586954 3 Q13573 1 Beta oxidation of decanoyl coa to octanoyl coa coa 0.5665092123475332 0.7719685527141887 0.4401330531819569 1.0 0.7960494142983977 5 Q16836 1 Beta oxidation of octanoyl coa to hexanoyl coa 0.5665092123475332 0.7719685527141887 0.4401330531819569 1.0 0.7960494142983977 5 Q16836 1 Interleukin 3 interleukin 5 and gm csf signaling 0.5909937586710283 0.7708617734530661 0.4407888673443767 1.0 0.7960494142983977 4 P62993 1 Suppression of apoptosis 0.642332789559546 0.7685507758116781 0.4421600367997103 1.0 0.7972187804405172 2 P23246 1 Notch3 activation and transmission of signal to the nucleus 0.6398858075040726 0.7588305185500082 0.4479539469372793 1.0 0.8010899620940761 2 Q92542 1 Noncanonical activation of notch3 0.6398858075040726 0.7588305185500082 0.4479539469372793 1.0 0.8010899620940761 2 Q92542 1 Er to golgi anterograde transport 0.3197283755683071 0.7306689382066952 0.4649813927488631 1.0 0.8161724748684904 57 Q9BUF5,Q9BVA1,Q13409,P62820,P61923,P61163,O75935,P24390,P68371 9 Transport to the golgi and subsequent modification 0.3197283755683071 0.7306689382066952 0.4649813927488631 1.0 0.8161724748684904 57 Q9BUF5,Q9BVA1,Q13409,P62820,P61923,P61163,O75935,P24390,P68371 9 Aurka activation by tpx2 0.3762186821513884 0.7241321161385859 0.4689846292953783 1.0 0.8163218067884455 24 P61163,O75935,P07437,P68371 4 Signal amplification 0.6771062613093392 0.7223634154826346 0.470071073432708 1.0 0.8163218067884455 3 P04899 1 Recruitment of mitotic centrosome proteins and complexes 0.3720796118122752 0.7223207350234929 0.4700973075511609 1.0 0.8163218067884455 25 P61163,O75935,P07437,P68371 4 Attenuation phase 0.4523739340403859 0.7124968505973204 0.4761571609893211 1.0 0.8225100107259833 10 P04792 1 Hsf1 activation 0.4181419413913793 0.7096355286807532 0.4779301815832348 1.0 0.8234143520610504 13 P35244,P04792 2 Disorders of transmembrane transporters 0.3148638286974781 0.6974270130316855 0.4855356011846283 1.0 0.8277676889765694 72 P28070,P28072,Q9BUN8,P49721,P20618,P60900,Q8NFH4,Q99436,P28074,P37198,Q9BTX1 11 Triglyceride catabolism 0.5718929079301444 0.6959817174424593 0.4864402793444471 1.0 0.8277676889765694 4 P62136,P17612 2 Triglyceride metabolism 0.5718929079301444 0.6959817174424593 0.4864402793444471 1.0 0.8277676889765694 4 P62136,P17612 2 Regulation of glycolysis by fructose 2 6 bisphosphate metabolism 0.6694408684347481 0.6949877299939304 0.4870629910781572 1.0 0.8277676889765694 3 Q14738 1 Interleukin 4 and interleukin 13 signaling 0.4372316231370312 0.689036998738002 0.4907999846651065 1.0 0.8314580717077255 11 P09601 1 Neurotransmitter receptors and postsynaptic signal transmission 0.3710504039414331 0.686449016204873 0.4924300040471283 1.0 0.8331485819436651 24 Q9BUF5,Q9BVA1,P68371 3 Hdr through homologous recombination hrr 0.3863818512340429 0.6802453562638934 0.4963491177619386 1.0 0.838399456809382 19 P41440,Q9UQ84,P35250 3 Metabolism of vitamins and cofactors 0.3515482898794536 0.6795242497667077 0.4968057479272589 1.0 0.838399456809382 34 P41440,Q9NRN7,Q9NVE7,O75874,P35270,P43490,P00374,Q9H2D1 8 Activation of atr in response to replication stress 0.4073258214227673 0.6749645390528759 0.4996982947716673 1.0 0.8422024968146515 14 Q9Y619,P35250 2 Protein folding 0.3607038936321509 0.6642305516377401 0.5065427622875203 1.0 0.8441157772570679 28 Q9BUF5,Q9BVA1,P68371 3 Activation of bh3 only proteins 0.4423049604817888 0.6621282645613219 0.5078890230133517 1.0 0.8441157772570679 10 P61981,P31751,P27348 3 Cd28 co stimulation 0.5211046068085311 0.6603332117595745 0.50904002167248 1.0 0.8441157772570679 6 P31751 1 Proton coupled monocarboxylate transport 0.6146003262642801 0.6603194848950628 0.5090488286827877 1.0 0.8441157772570679 2 P53985 1 Signaling by vegf 0.3857313309152291 0.6584537101384801 0.5102466323575783 1.0 0.8441157772570679 18 Q9UQB8,P04792 2 Sulfur amino acid metabolism 0.4483720191231903 0.6541703260530172 0.5130020770735291 1.0 0.8441157772570679 9 Q13126 1 Plasma lipoprotein assembly remodeling and clearance 0.4187575863762063 0.6487020126736721 0.5165310032222723 1.0 0.8478055569700559 12 P61916,Q8WTV0,P07237 3 Processing of dna double strand break ends 0.3677840788614574 0.6374266088380364 0.5238470007195555 1.0 0.8555518549546148 23 Q9NXR7,Q9UNS1,O96028,P35250,Q9UQ84 5 Transcription of the hiv genome 0.38970535692694 0.6317856905266604 0.5275269252586283 1.0 0.8604956528352378 16 Q92804,P18074,O00267,P29083,P19388 5 Prevention of phagosomal lysosomal fusion 0.6446348429212578 0.6083375615822774 0.5429636136457847 1.0 0.8764451809830109 3 Q9H267,P51149 2 Translesion synthesis by polh 0.4092553604384739 0.597497070075297 0.5501755625671594 1.0 0.8834151785406787 12 P41440,P35250 2 Esr mediated signaling 0.3502234462863768 0.5942126591727478 0.5523698868470008 1.0 0.8834151785406787 29 P04792,Q08752,P31751,Q15185,P19388 5 Mitochondrial fatty acid beta oxidation 0.396924157534946 0.5893475625017025 0.5556281449973781 1.0 0.8834151785406787 13 Q16836,P40939 2 Stimuli sensing channels 0.5013970631190727 0.5808677963679876 0.5613295580583941 1.0 0.8834151785406787 6 Q9C0H2 1 Pyruvate metabolism and citric acid tca cycle 0.3397178567502414 0.5808255236329881 0.5613580510896963 1.0 0.8834151785406787 34 P48735,P21796 2 Rac1 gtpase cycle 0.3469603942288164 0.5803393048712278 0.5616858267200977 1.0 0.8834151785406787 30 Q14739 1 Peroxisomal lipid metabolism 0.468604911612058 0.5730859129158123 0.566586524911727 1.0 0.8868516438705778 7 P51648,Q15067 2 Synthesis of pips at the plasma membrane 0.5394383937592495 0.5728559055365088 0.5667422624598775 1.0 0.8868516438705778 4 Q9Y217 1 Ddx58 ifih1 mediated induction of interferon alpha beta 0.4234185235431245 0.5691213329210625 0.569273802019268 1.0 0.8868516438705778 10 P05067 1 Transcriptional regulation by mecp2 0.3912438343450101 0.557621874645769 0.577102616036516 1.0 0.8924983038765686 13 Q14739 1 Pten regulation 0.3035930019094658 0.5539180214096752 0.5796349511014678 1.0 0.8924983038765686 56 P28070,O75832,P28072,Q9Y2Q5,P49721,P20618,P60900,P31751,Q6IAA8,Q99436,P28074 11 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0.5334569691471595 0.5508522989993305 0.5817349292326077 1.0 0.8924983038765686 4 P12235 1 Darpp 32 events 0.4631489103709634 0.549942913551405 0.5823585290848627 1.0 0.8924983038765686 7 P10644,P62136,P17612,Q14738 4 Striated muscle contraction 0.6258771479888539 0.5450986266647466 0.5856856871806364 1.0 0.8934418237315725 3 Q9NYL9 1 Dual incision in gg ner 0.3653360249721198 0.5419016834228149 0.5878862370162352 1.0 0.895445551452891 19 P18074,P41440,P35250 3 Hemostasis 0.2931147582825972 0.5398039961934251 0.5893322108659014 1.0 0.8958937184789596 92 Q8IWA4,P60903,Q9BUF5,P07737,Q9BVA1,P05067,P42785,Q9NSK0,P30626,Q9NTK5,Q8NBX0,O15439,O43852,Q08380,P68371 15 Erks are inactivated 0.528453608382613 0.5326356844168353 0.5942857952558636 1.0 0.9003088254565841 4 Q8IV63,Q14738 2 Alpha oxidation of phytanate 0.6172641658364153 0.5168180055316896 0.6052832096839913 1.0 0.904025871273002 3 P51648 1 Pka mediated phosphorylation of creb 0.6167029179526213 0.5149928797065978 0.6065579956089922 1.0 0.904025871273002 3 P10644 1 Glucagon signaling in metabolic regulation 0.6167029179526213 0.5149928797065978 0.6065579956089922 1.0 0.904025871273002 3 P10644 1 Creb1 phosphorylation through the activation of adenylate cyclase 0.6167029179526213 0.5149928797065978 0.6065579956089922 1.0 0.904025871273002 3 P10644 1 Pka activation in glucagon signalling 0.6167029179526213 0.5149928797065978 0.6065579956089922 1.0 0.904025871273002 3 P10644 1 Vasopressin regulates renal water homeostasis via aquaporins 0.6167029179526213 0.5149928797065978 0.6065579956089922 1.0 0.904025871273002 3 P10644 1 Unfolded protein response upr 0.3314411225020697 0.5123589590424148 0.6083998086640006 1.0 0.904025871273002 34 Q15024,P61421,Q9Y2L1,Q9NQT5,Q8N6T3,Q13217,Q9Y5M8,Q9NWM8,P43307,Q9Y3B2 10 Carnitine metabolism 0.521969022072788 0.5092963630748135 0.6105445068155979 1.0 0.9051717210157008 4 O43772 1 Plasma lipoprotein clearance 0.4068011854779956 0.4893306538397944 0.6246076223842505 1.0 0.913084326530485 10 Q8WTV0 1 Foxo mediated transcription 0.4065456143701359 0.4881212938637951 0.6254639290919959 1.0 0.913084326530485 10 P61981,P31751,P27348 3 Phospholipid metabolism 0.3387669199002671 0.4827117870102594 0.6293003928294185 1.0 0.913084326530485 26 Q9UG56,P48651,Q8IV08,Q9Y217,P61106,P35790,P40939,Q9NPH0 8 Degradation of the extracellular matrix 0.4463621894938691 0.4800895285233626 0.6311637337958071 1.0 0.913084326530485 7 P17655,P07384,Q92542,P35613,P78536 5 Signaling by notch1 0.4161541458011404 0.4729983954171559 0.63621432395382 1.0 0.913084326530485 8 Q92542,P63208,Q13573,Q96J02 4 Endosomal sorting complex required for transport escrt 0.5109043166892854 0.4702251894242585 0.6381941393495822 1.0 0.9132897672776866 4 Q8WUX9,Q99816 2 Antigen processing ubiquitination proteasome degradation 0.2919864789585938 0.4533604943145455 0.6502891787242344 1.0 0.9215926210306892 80 P28070,P28072,P20618,P55786,P49721,P60900,Q9UIQ6,P63208,Q16763,Q96J02,Q99436,P28074 12 Dap12 interactions 0.5046687600089255 0.4486538123581602 0.6536814082343039 1.0 0.923990181621134 4 P62993 1 Signaling by wnt 0.2937704904672593 0.4480957478490819 0.6540840967014552 1.0 0.923990181621134 71 P28070,P07737,P28072,P49721,P20618,P60900,P63208,Q14738,P31751,Q99436,P28074 11 Golgi cisternae pericentriolar stack reorganization 0.4371675892891046 0.4428054750643019 0.6579064428139059 1.0 0.9255439524942154 7 P62820 1 Recognition of dna damage by pcna containing replication complex 0.3589143230324298 0.4204922753636579 0.6741258712551637 1.0 0.9390965262278708 15 P41440,P35250 2 Regulation of tp53 activity through phosphorylation 0.341351619009193 0.4167425903334518 0.6768666983414144 1.0 0.9390965262278708 21 Q92804,Q9UQ84,P35250 3 Ra biosynthesis pathway 0.5849016521318513 0.4154821746398324 0.6777889615848565 1.0 0.9390965262278708 3 O94788 1 Neuronal system 0.3159202602602184 0.4137897860323088 0.679028064867345 1.0 0.9390965262278708 38 O95197,P41440,P21964,Q9BUF5,Q9BVA1,Q9Y639,P04899,Q14168,P68371 9 Depolymerisation of the nuclear lamina 0.4290968532897489 0.4107229352179375 0.6812757074150775 1.0 0.9411665019148522 7 Q9Y2U8,P06493,P42166,P50402,P20700,P42167 6 Neddylation 0.2907604300898361 0.4077912347412318 0.6834269492877314 1.0 0.9411665019148522 63 P28070,P61962,O75832,P28072,P49721,Q99627,P20618,P60900,P63208,Q9UL46,Q99436,P28074 12 Polymerase switching 0.3811720132956279 0.4068615527991668 0.6841096753859639 1.0 0.9411665019148522 11 P35250 1 Metabolism of water soluble vitamins and cofactors 0.3255881388004856 0.4061337415397437 0.6846443349502431 1.0 0.9411665019148522 29 P41440,Q96EY8,Q9NRN7,Q9NVE7,Q4G0N4,Q8NFF5,P43490,P00374,P78417,Q9H2D1 10 Dual incision in tc ner 0.3260582626115326 0.386603025235767 0.6990501179677162 1.0 0.949134381019734 25 P18074,P41440,P35244,P35250 4 Vitamin b5 pantothenate metabolism 0.572696986872482 0.3795371997691191 0.7042889855514922 1.0 0.9508569303807004 3 Q9NRN7 1 Intrinsic pathway for apoptosis 0.3535077250103671 0.3705194213658855 0.7109955084899457 1.0 0.9508569303807004 14 Q9NR28,P31751,Q07021,P61981,P27348 5 Formation of the early elongation complex 0.3858913912915844 0.3669233072689622 0.7136762255125217 1.0 0.9508569303807004 9 P18074,O00267,P19388 3 Ire1alpha activates chaperones 0.3328784766615665 0.3617175645349459 0.717563100020175 1.0 0.9508569303807004 21 P61421,Q8N6T3,Q13217,Q9Y5M8,Q9NWM8,P43307 6 Transcriptional regulation by e2f6 0.4566054933568634 0.3566107468683953 0.7213832309615862 1.0 0.9508569303807004 5 Q13185 1 Lagging strand synthesis 0.3507474238181942 0.3557315977284326 0.7220415793260992 1.0 0.9508569303807004 14 P41440,P35250 2 Polymerase switching on the c strand of the telomere 0.3620792941494059 0.3544017133814709 0.7230378506940673 1.0 0.9508569303807004 12 P35250 1 Adaptive immune system 0.2988003496523767 0.3457939806470922 0.7294975491736753 1.0 0.9541327530851432 153 P28070,P49721,Q9UIQ6,Q13409,P31751,Q99436,P61163,P62993,P28074,P68371,Q9BUF5,P28072,Q9BVA1,P55786,P63208,P10619,Q96J02,Q9NZ08,P20618,Q9NSK0,P60900,Q14738,Q16763,O75935 24 Pcna dependent long patch base excision repair 0.3481299565745807 0.341809533326411 0.732494234698092 1.0 0.9558687141901836 14 P41440,P35250 2 Transmission across chemical synapses 0.3152236079612881 0.3367468932634806 0.7363077100840338 1.0 0.9565966099271654 30 Q9BUF5,Q9BVA1,P68371 3 Late endosomal microautophagy 0.4063743565600679 0.3240981731655792 0.745863709952745 1.0 0.9565966099271654 7 P08670,Q8WUX9,Q99816 3 Factors involved in megakaryocyte development and platelet production 0.3060747662277348 0.3231548246668813 0.7465779915917539 1.0 0.9565966099271654 36 Q9NSK0,Q9BUF5,Q9BVA1,P68371 4 Gap filling dna repair synthesis and ligation in gg ner 0.3444670670847325 0.3224985991478855 0.7470749988336174 1.0 0.9565966099271654 14 P41440,P35250 2 Ikk complex recruitment mediated by rip1 0.5126427406199049 0.3160867813894278 0.7519366397127476 1.0 0.9565966099271654 2 Q13546 1 Ticam1 rip1 mediated ikk complex recruitment 0.5126427406199049 0.3160867813894278 0.7519366397127476 1.0 0.9565966099271654 2 Q13546 1 Tgf beta receptor signaling in emt epithelial to mesenchymal transition 0.5114192495921792 0.3126481663434963 0.7545479798091261 1.0 0.9565966099271654 2 Q9Y624 1 Apoptosis 0.2805171053553541 0.3119275015102766 0.7550956213484787 1.0 0.9565966099271654 79 P26583,P28070,Q9NR28,O75832,P28072,P49721,P20618,P60900,P08670,P61981,P48556,Q9UL46,P31751,Q07021,Q99436,P27348,P28074 17 Diseases of metabolism 0.3080699779012198 0.3113275213469883 0.7555516471427763 1.0 0.9565966099271654 33 O43505,O75340,Q96EY8,Q8NCH0,O75874,P54802,P10619,P16278,P15586,P10253,Q99519 11 Microrna mirna biogenesis 0.4010837646594071 0.3048048542927703 0.7605147841628144 1.0 0.960896556034346 7 Q8WYQ5 1 Role of abl in robo slit signaling 0.4595918367346883 0.3039905948504864 0.7611350565249295 1.0 0.960896556034346 4 O75122,Q7Z460,O94813 3 Rhoc gtpase cycle 0.3164528170071717 0.3011971631553092 0.7632641529208868 1.0 0.9626623478944772 24 Q14739 1 Telomere c strand lagging strand synthesis 0.3333023327679217 0.2978414858910646 0.7658241495060338 1.0 0.9649677141959394 16 P41440,P35250 2 Phase ii conjugation of compounds 0.3244106186887631 0.2957211007889531 0.7674430814413269 1.0 0.9651621959347984 20 P21964,Q8TB61,O14880,O60701,P78417,Q9NUJ1 6 Energy dependent regulation of mtor by lkb1 ampk 0.4540129456917184 0.2876527830300363 0.7736125366307909 1.0 0.9701439802848548 4 Q9Y2Q5 1 Cytokine signaling in immune system 0.2957688622893631 0.2709375086502372 0.7864390958410084 1.0 0.9771245606178678 158 P28070,P49721,P07237,P31751,P09601,Q99436,P37198,Q13501,P05067,Q8NFH4,P11233,P62993,P28074,P52597,P28072,Q13126,P63208,P04083,O75832,P20618,P60900,P51809,P22626,Q14738,O14979,Q00169,Q9BTX1 27 Resolution of ap sites via the multiple nucleotide patch replacement pathway 0.323329091327045 0.2700676593297519 0.7871082020437135 1.0 0.9771245606178678 18 P41440,Q86W56,P35250 3 Synthesis of ketone bodies 0.4955138662316529 0.2697765539809285 0.7873321614687809 1.0 0.9771245606178678 2 P35914 1 Ketone body metabolism 0.4955138662316529 0.2697765539809285 0.7873321614687809 1.0 0.9771245606178678 2 P35914 1 Homology directed repair 0.2974057557483629 0.2519706881336631 0.801063720436892 1.0 0.9844830539665828 35 P41440,Q9NXR7,Q9UNS1,O96028,P35250,Q9UQ84 6 Programmed cell death 0.2718623688386705 0.2479170301839588 0.8041986029892767 1.0 0.985700308823184 89 P28070,Q9NR28,P49721,P08670,P48556,P31751,Q99436,P26583,P27348,P28074,P41440,P28072,Q9UL46,O75832,P20618,P60900,Q8WUX9,Q07021,P61981 19 Synthesis of gdp mannose 0.4824632952691686 0.2372325989774024 0.8124763477121739 1.0 0.9886518806118616 2 Q96IJ6 1 Pkmts methylate histone lysines 0.4048968353624237 0.2363966242057071 0.8131249154652944 1.0 0.9886518806118616 6 Q03164 1 Termination of translesion dna synthesis 0.3252986779283069 0.2251141927789539 0.8218904400935279 1.0 0.9890855643071912 14 P41440,P35250 2 P75ntr regulates axonogenesis 0.5104039167686737 0.2195983220575298 0.8261839983190935 1.0 0.9890855643071912 3 Q9NQC3,P61586 2 Regulation of pyruvate dehydrogenase pdh complex 0.3523800987136013 0.2157563968091537 0.8291776380631695 1.0 0.9890855643071912 8 Q15120 1 Glucagon like peptide 1 glp1 regulates insulin secretion 0.4235958306675175 0.205628190051488 0.8370813555860699 1.0 0.9890855643071912 4 P10644 1 Class i mhc mediated antigen processing presentation 0.2622066246326555 0.1972384467795739 0.8436409453391889 1.0 0.9912206331995436 100 Q9NZ08,P28070,P28072,P55786,P49721,P20618,P60900,Q9UIQ6,P63208,Q16763,Q96J02,Q99436,P28074 13 Formation of rna pol ii elongation complex 0.3102381352227599 0.1958513536343749 0.844726513951473 1.0 0.9912206331995436 18 Q9GZS3,P18074,O00267,Q7KZ85,P19388 5 Mrna capping 0.345859153233704 0.1928198222510907 0.8471000788874847 1.0 0.9912206331995436 8 P18074,P19388 2 Budding and maturation of hiv virion 0.3897754714840525 0.1921433404562645 0.8476299265763982 1.0 0.9912206331995436 6 Q8WUX9,Q99816 2 Apc c cdc20 mediated degradation of cyclin b 0.3423678563665997 0.1808512110158537 0.8564843652255538 1.0 0.993066477303894 8 Q96DE5 1 Signaling by receptor tyrosine kinases 0.2681433795344282 0.1715099564731179 0.8638228023046342 1.0 0.9934533351821664 81 P61421,P04792,P52597,Q9UQB8,P31943,Q01085,Q14738,P31751,P11233,Q93050,Q9Y487,P62993,P31483,P19388,Q15904 15 Aryl hydrocarbon receptor signalling 0.4862911526477538 0.169690884785806 0.8652532429934299 1.0 0.9934533351821664 3 Q15185 1 M phase 0.2895680078729793 0.1657250084673768 0.8683733642860583 1.0 0.9934533351821664 161 Q01105,P28070,P49721,Q86XL3,Q13409,Q99436,P37198,Q14739,Q8IXJ6,Q8NFH4,P07437,P62820,P61163,P28074,P68371,Q9BUF5,P28072,Q9BVA1,Q96DE5,O75832,P20618,P60900,Q9H8Y8,Q14738,Q16763,O75935,Q9BTX1 27 Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1 0.4490212071778173 0.165268770305984 0.8687324384621011 1.0 0.9934533351821664 2 P06493 1 Global genome nucleotide excision repair gg ner 0.2883028261941383 0.162507679167689 0.8709060815553813 1.0 0.9934533351821664 33 P41440,Q92905,Q99627,P35250,P35251,O96019,Q9BT78,P18074,P54727,P35244,P18887 11 Rnd3 gtpase cycle 0.3099336177213739 0.1611395793474955 0.8719834677444611 1.0 0.9934533351821664 15 P38159,Q9Y2I1,Q9NYL9,Q03001 4 Smooth muscle contraction 0.3331689585030885 0.1609816909516612 0.872107821057184 1.0 0.9934533351821664 9 P04083 1 Signaling by egfr 0.3877960816327416 0.1570820771604524 0.8751801625742295 1.0 0.9943857364420986 5 P62993 1 Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.3541309047001769 0.1512670644257627 0.8797650490648192 1.0 0.9967048043528944 7 Q96DE5 1 Signaling by notch1 pest domain mutants in cancer 0.3501287423411828 0.1398381605246942 0.8887878617691587 1.0 1.0 7 Q92542,P63208,Q13573 3 Ethanol oxidation 0.4671607446681854 0.1352683061927316 0.8923997427256196 1.0 1.0 3 P30837 1 Ptk6 regulates cell cycle 0.4314845024469808 0.1342726010586785 0.8931870182115467 1.0 1.0 2 P24941 1 Synthesis secretion and inactivation of glucagon like peptide 1 glp 1 0.3915484400662273 0.1333117099813531 0.8939468670362469 1.0 1.0 4 P67812 1 Incretin synthesis secretion and inactivation 0.3915484400662273 0.1333117099813531 0.8939468670362469 1.0 1.0 4 P67812 1 Regulation of insulin secretion 0.324022392533343 0.1302261372321517 0.8963875161379118 1.0 1.0 9 P04899,P29966,P10644 3 Deactivation of the beta catenin transactivating complex 0.3651393466292935 0.1274614655085681 0.8985751704378333 1.0 1.0 6 P31751 1 Integrin cell surface interactions 0.4622603019175798 0.1271959992500426 0.8987852717992109 1.0 1.0 3 P35613,Q9Y624 2 Postmitotic nuclear pore complex npc reformation 0.2940392307594223 0.1261908495956187 0.8995808544285406 1.0 1.0 21 Q92973,Q8NFH4,Q8NFH5,P37198,Q9BTX1 5 Intracellular signaling by second messengers 0.2645263099831829 0.1178855759003228 0.906158322313884 1.0 1.0 72 P28070,O75832,P28072,Q9Y2Q5,P49721,P20618,P60900,Q14738,P31751,Q6IAA8,P10644,Q99436,P62993,P28074 14 Receptor mediated mitophagy 0.4168026101141943 0.1118653866188586 0.9109301417723524 1.0 1.0 2 P67870 1 Synthesis of bile acids and bile salts 0.3662719477337714 0.1088430223008496 0.9133269996405884 1.0 1.0 5 Q9BZF3,P22307,P51659,Q96SU4 4 Bile acid and bile salt metabolism 0.3662719477337714 0.1088430223008496 0.9133269996405884 1.0 1.0 5 Q9BZF3,P22307,P51659,Q96SU4 4 Rho gtpases activate wasps and waves 0.3060838248635058 0.1075274628069524 0.9143705394519012 1.0 1.0 12 Q9UQB8 1 Opioid signalling 0.2990154115759535 0.1003090667134931 0.9200989596030658 1.0 1.0 13 P04899,P08754,Q14738,P10644 4 Phosphorylation of the apc c 0.3140504818472012 0.0986660563577279 0.9214034204229208 1.0 1.0 9 Q96DE5 1 Abortive elongation of hiv 1 transcript in the absence of tat 0.3340235273210029 0.0967881209101611 0.9228946577811804 1.0 1.0 7 O00267,P19388 2 Atf6 atf6 alpha activates chaperone genes 0.4045676998368692 0.0955903564513532 0.923845924562775 1.0 1.0 2 P27797 1 Scavenging by class a receptors 0.4045676998368692 0.0955903564513532 0.923845924562775 1.0 1.0 2 P27797 1 Atf6 atf6 alpha activates chaperones 0.4045676998368692 0.0955903564513532 0.923845924562775 1.0 1.0 2 P27797 1 Trafficking and processing of endosomal tlr 0.4045676998368676 0.0955903564513513 0.9238459245627766 1.0 1.0 2 Q99538 1 Aberrant regulation of mitotic exit in cancer due to rb1 defects 0.3144957581354698 0.0937271534817608 0.925325899861311 1.0 1.0 8 Q96DE5 1 Cell surface interactions at the vascular wall 0.3076923076923082 0.0865955538730798 0.9309930001210645 1.0 1.0 10 P08195,P05026,P05556,P53985,P35613,P54709,Q9Y624,P62993,P14174 9 Signaling by cytosolic fgfr1 fusion mutants 0.3536095576012641 0.0839594519759103 0.9330886705280972 1.0 1.0 5 P62993 1 Formation of incision complex in gg ner 0.3021822419603273 0.0785352206146721 0.9374023147307337 1.0 1.0 11 P18074 1 Dna strand elongation 0.2832765844658595 0.0738860642429724 0.941101044661121 1.0 1.0 22 P41440,Q9BRT9,P35250 3 Muscle contraction 0.2806005834680576 0.066708984739611 0.9468133814596428 1.0 1.0 23 P04083,P30626,Q9NYL9 3 Phosphorylation of emi1 0.3727569331158322 0.0627780329575628 0.9499432585186952 1.0 1.0 2 P06493 1 Interaction between l1 and ankyrins 0.4104447164422667 0.0600191521692013 0.9521403809618952 1.0 1.0 3 Q12955,Q13813 2 Resolution of abasic sites ap sites 0.2815415185361729 0.0583581163585941 0.9534633761865594 1.0 1.0 21 P41440,Q86W56,P35250 3 Signaling by hippo 0.3372805226623173 0.0557369506472787 0.9555513628824104 1.0 1.0 5 P31946,P62258,Q4VCS5,Q9UDY2 4 Signaling by fgfr1 in disease 0.3304902837338277 0.0534242269215696 0.9573939024813248 1.0 1.0 6 P62993 1 Fgfr1 mutant receptor activation 0.3304902837338277 0.0534242269215696 0.9573939024813248 1.0 1.0 6 P62993 1 Regulation of tp53 activity 0.2726614729605437 0.0526400372077881 0.9580187160975552 1.0 1.0 33 P31751,Q92804,Q9UQ84,P35250 4 Detoxification of reactive oxygen species 0.2969325153374165 0.0495730964449351 0.9604625861905428 1.0 1.0 9 P04179,Q96HE7,P30044,P07237,P32119,P30041,Q16881,P30048 8 Mastl facilitates mitotic progression 0.3875968992248083 0.0402123970970361 0.9679237941709172 1.0 1.0 3 P06493,P30153 2 Runx1 regulates expression of components of tight junctions 0.3368678629690008 0.0398435193833161 0.9682178803095456 1.0 1.0 2 Q16625 1 Signaling by fgfr2 in disease 0.3226800061560979 0.039574897535341 0.9684320406212544 1.0 1.0 6 P19388 1 Rab geranylgeranylation 0.2825893219874971 0.0390543518805548 0.9688470551023214 1.0 1.0 15 Q969Q5,P62820,P61020 3 Tp53 regulates metabolic genes 0.2685226266568311 0.0206375584802945 0.9835347795046412 1.0 1.0 32 P13073,P15954,Q9Y2Q5,Q04917,P31751,P00403,Q6IAA8,O75880,P20674,P61981,P27348 11 G2 m dna damage checkpoint 0.2689711473098986 0.0177274803120487 0.9858562579714087 1.0 1.0 30 Q9NXR7,O96028,Q9UQ84,P35250 4 Fcgamma receptor fcgr dependent phagocytosis 0.274104683431097 0.0146094935534563 0.9883437253013267 1.0 1.0 19 Q9UQB8,Q8IV08 2 Activation of the pre replicative complex 0.2751866121649191 0.0110752171987164 0.991163435839444 1.0 1.0 13 Q9Y619 1 G protein mediated events 0.2801297055824631 0.0079495159874298 0.9936572707324338 1.0 1.0 9 P04899,P08754,P10644 3 Notch hlh transcription pathway 0.2851897184822499 0.0024344065971862 0.9980576264799148 1.0 1.0 3 Q13547,Q13573 2 Aspartate and asparagine metabolism 0.2948142098815908 0.0020243022785833 0.9983848415686196 1.0 1.0 5 P00505,O75746,P08243,Q9UJS0 4