Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size Protein localization 0.5459143229774356 3.0012430033712785 0.0026887989779251 0.977425351932279 0.3440493661230855 72 P21796,Q99595,P46379,P12235,O75874,Q9NR77,Q9NS69,Q15067,Q8N4Q1,Q5JRX3,O14925,P09601,Q8N4H5 13 Cholesterol biosynthesis 0.8020754305498897 2.9263549379003817 0.0034295940639015 0.9920705210577214 0.3440493661230855 16 Q16850,Q15125,P37268,P48449,Q15392,Q15800,Q9BWD1,Q14739 8 Metabolism of steroids 0.566204762701364 2.646386125562427 0.0081356891949626 0.999989889155912 0.3440493661230855 46 Q16850,Q15125,P37268,P48449,P38435,Q15392,Q15800,Q9BWD1,P30536,Q14739,P04062 11 Mitochondrial protein import 0.6132276061914052 2.600802757378752 0.0093005911345309 0.999998067138973 0.3446113767742 35 P21796,Q99595,Q9NS69,O14925,Q8N4Q1,Q5JRX3,Q8N4H5 7 Mtor signalling 0.7013252915338039 2.543783805181245 0.010965893332562 0.999999819088597 0.3758245123449769 18 P62942,P06730 2 Sphingolipid metabolism 0.6433915480190671 2.5137014245627674 0.0119471532230108 0.9999999552817608 0.3758245123449769 25 Q16739,P17900,Q96G23,P51648,P07602,Q06136,P10619,O95470,Q13510,O15270,P04062 11 Downstream signaling events of b cell receptor bcr 0.5348259448175513 2.3546213694361473 0.0185415875809429 0.9999999999964057 0.4109427237430454 45 P62942,P28070,P25786,P20618,P28074,P49721,P28072 7 Signaling by the b cell receptor bcr 0.5195232791220582 2.27749234497718 0.0227568412389718 0.9999999999999916 0.4172382720133466 47 P62942,P28070,P25786,P20618,P28074,P49721,P28072 7 Biological oxidations 0.5196050826533065 2.2696314834099884 0.0232299517436043 0.9999999999999958 0.4172382720133466 46 P07099,Q16850,O15217,Q9UJ14,Q9NUJ1,Q96DG6,O43169 7 Mtorc1 mediated signalling 0.7448790814124125 2.252672976027863 0.0242797760732507 0.9999999999999992 0.4234947882577902 12 P62942 1 Metabolism of cofactors 0.937683942002394 2.251356271029267 0.024362981426762 0.9999999999999992 0.4234947882577902 5 P00374,O75874,P35270 3 Metabolism of folate and pterines 0.7678634006845961 2.1812169778261734 0.0291673716519598 1.0 0.4726379662363058 9 P00374,P41440,Q9H2D1,P34896 4 Antigen processing cross presentation 0.4933568941804014 2.1285669178514897 0.0332901080013412 1.0 0.4873073013466599 54 P28070,P25786,P10321,P20618,Q9UIQ6,Q03518,P28074,P49721,P28072 9 Slc mediated transmembrane transport 0.6264673601528256 2.1175580635653937 0.0342125129667945 1.0 0.4873073013466599 18 Q9UBX3,Q96QD8,P12235,Q70HW3,P35613 5 Mrna decay by 3 to 5 exoribonuclease 0.6586188386161331 2.108867820826686 0.034955992497168 1.0 0.4873073013466599 15 Q969T7 1 Gpcr ligand binding 0.7748359506159377 2.1006874666759465 0.0356684102492654 1.0 0.4894589549853089 8 P07602,P42892,Q9BYT8,Q9NRV9 4 Cdt1 association with the cdc6 orc origin complex 0.5232491792625187 2.0914455453388605 0.0364881430262631 1.0 0.4894589549853089 40 P28070,P25786,Q9Y619,P20618,P28074,P49721,P28072 7 Pink1 prkn mediated mitophagy 0.7385685793605429 2.080610106169075 0.0374696081145842 1.0 0.4930580207975195 10 P21796,Q9NS69,Q8N4H5 3 Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.7444632500095646 2.07421433449488 0.0380594095364053 1.0 0.4961819317338765 9 P46379,P09601,P51648 3 Class a 1 rhodopsin like receptors 0.8543575418777626 2.045469761917511 0.0408085673704483 1.0 0.505015357594387 6 P07602,P42892,Q9BYT8,Q9NRV9 4 Peptide ligand binding receptors 0.8543575418777626 2.045469761917511 0.0408085673704483 1.0 0.505015357594387 6 P07602,P42892,Q9BYT8,Q9NRV9 4 Mitotic g1 phase and g1 s transition 0.4426565161648207 2.0047751263884535 0.0449870928304518 1.0 0.5322842580275314 78 P28070,P25786,Q9Y619,P30154,P00374,P20618,P60900,Q9NR33,P31749,P28074,P30153,P49721,P28072 13 Switching of origins to a post replicative state 0.4705746140011868 1.9772560010635911 0.0480127003814279 1.0 0.5444169323750921 58 P28070,P25786,Q9Y619,P60900,P20618,P28074,Q9UJX6,Q9UJX3,P49721,P28072 10 Interleukin 4 and interleukin 13 signaling 0.6631175424249744 1.956780800217755 0.0503732453449654 1.0 0.5584687357930028 13 P31749,P04083,P09601 3 Mitophagy 0.6595979655115446 1.9384634684032809 0.0525667036049737 1.0 0.5737513075643644 13 P21796,Q9NS69,Q8N4H5 3 Transport of inorganic cations anions and amino acids oligopeptides 0.7080286606801428 1.9048574894695616 0.0567985984493533 1.0 0.5871687544884787 9 Q96QD8,Q70HW3 2 Heme degradation 0.9437326242322768 1.896635629228859 0.0578760448045296 1.0 0.5871687544884787 4 P30519 1 Glycosphingolipid metabolism 0.6201156100728795 1.8963975913510105 0.0579074901457277 1.0 0.5871687544884787 15 Q16739,P17900,P07602,P10619,Q13510,P04062 6 Rhoa gtpase cycle 0.4728658399804336 1.8959104141629928 0.0579718916225333 1.0 0.5871687544884787 49 P30519,O15173,P41440,Q14739,Q8NBN3 5 Ctla4 inhibitory signaling 0.8150833175535991 1.887883240122668 0.0590416270038307 1.0 0.5871687544884787 6 P30154,P30153 2 Metabolism of porphyrins 0.6974771896105489 1.8867325467399156 0.0591963077402393 1.0 0.5871687544884787 10 P30519 1 Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 0.4727759867115348 1.8802024021182056 0.0600804983659097 1.0 0.5871687544884787 47 P28070,P25786,P60900,P20618,P28074,Q9UJX6,Q9UJX3,P49721,P28072 9 Glutathione conjugation 0.6064445388069369 1.875387309949407 0.0607394596564514 1.0 0.5871687544884787 16 O15217,Q9UJ14 2 G1 s specific transcription 0.6946013787174601 1.8730009232733027 0.0610682574985208 1.0 0.5871687544884787 10 Q9Y619 1 Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation 0.9372792998942372 1.8723043907631545 0.0611645036684751 1.0 0.5871687544884787 4 P00374,P35270 2 Pyruvate metabolism 0.6143079351066718 1.8638932638193288 0.0623366948920705 1.0 0.5871687544884787 15 P21796,Q15120,O95563,P35613 4 Sphingolipid de novo biosynthesis 0.6916158182121785 1.8587229744486435 0.0630664152374491 1.0 0.5871687544884787 10 O15270,Q06136,O95470,Q96G23 4 Protein protein interactions at synapses 0.6168015050298954 1.8251900811964676 0.0679723500849645 1.0 0.5871687544884787 14 Q14168,P41440 2 Glycerophospholipid biosynthesis 0.5301140944617009 1.8112815094882049 0.0700972864372935 1.0 0.5871687544884787 26 P48651,Q96N66,Q99829,Q9NPH0,Q8IV08,P43304,P67870,Q8NCC3,O15228,P35790,Q9NQZ5,O95674 12 Potential therapeutics for sars 0.4897413309474111 1.7986418315283927 0.0720753557449138 1.0 0.5871687544884787 39 P62942,Q02790,P49356 3 Regulation of pten stability and activity 0.478293676243967 1.788985550578411 0.0736171426377985 1.0 0.5871687544884787 42 P28070,P25786,P20618,P31749,P28074,P49721,P28072 7 Orc1 removal from chromatin 0.4595509346553069 1.7860607248360345 0.0740894264625768 1.0 0.5871687544884787 50 P28070,P25786,Q9Y619,P20618,P28074,P49721,P28072 7 Negative regulation of notch4 signaling 0.4811292981876773 1.7833022811048296 0.0745371102899412 1.0 0.5871687544884787 41 P28070,P25786,P20618,P31749,P28074,P49721,P28072 7 Class i peroxisomal membrane protein import 0.675516868979407 1.7813444927629771 0.0748561901400455 1.0 0.5871687544884787 10 Q5T8D3,Q9NR77 2 Degradation of dvl 0.4858140724315419 1.767211693721911 0.0771927820454754 1.0 0.5871687544884787 39 P28070,P25786,P60900,P20618,P28074,P49721,P28072 7 Iron uptake and transport 0.5771131997514429 1.7627287215720064 0.0779462541779847 1.0 0.5871687544884787 17 P09601,P30519,Q9Y487 3 Regulation of ras by gaps 0.4881625596389403 1.7608626745910902 0.0782616487517708 1.0 0.5871687544884787 38 P28070,P25786,P20618,P28074,P49721,P28072 6 Signaling by notch4 0.4712016354378656 1.7600211072250294 0.0784042278539678 1.0 0.5871687544884787 43 P28070,P25786,P20618,P31749,P28074,P49721,P28072 7 Degradation of axin 0.4909867099524987 1.7592955167529754 0.0785273276988944 1.0 0.5871687544884787 37 P28070,P25786,P20618,P28074,P49721,P28072 6 Mitochondrial calcium ion transport 0.58601753376103 1.757589408832511 0.0788173967317631 1.0 0.5871687544884787 16 P21796,P45880,Q8WWC4 3 Degradation of beta catenin by the destruction complex 0.454347661979919 1.7394122507602732 0.0819622748897663 1.0 0.5983720835928892 50 P28070,P25786,P30154,P20618,P28074,P30153,P49721,P28072 8 Costimulation by the cd28 family 0.6012187442570811 1.7389660701422094 0.0820407312884354 1.0 0.5983720835928892 14 P30154,P31749,P30153 3 Regulation of runx3 expression and activity 0.4882288095750117 1.7376353025225186 0.0822750952670097 1.0 0.5983720835928892 37 P28070,P25786,P20618,P28074,P49721,P28072 6 Phase i functionalization of compounds 0.6002575663468402 1.733621529723453 0.0829852578432288 1.0 0.5983720835928892 14 P07099,Q96DG6,O43169 3 Interferon gamma signaling 0.5963919120508636 1.7120967119550814 0.0868788472226249 1.0 0.600397220391458 14 P19474,P04439,P15260,P10321 4 Regulation of hmox1 expression and activity 0.4540042371286362 1.7100470234071232 0.0872571779107158 1.0 0.600397220391458 46 P28070,P25786,P20618,P28074,P09601,P49721,P28072 7 Cyclin a cdk2 associated events at s phase entry 0.4680771841222897 1.703929068400422 0.0883943396198669 1.0 0.6016201965067176 42 P28070,P25786,P20618,P31749,P28074,P49721,P28072 7 G1 s dna damage checkpoints 0.4657802921656149 1.684701495976168 0.0920461777496546 1.0 0.6138477492383118 42 P28070,P25786,P60900,P20618,P28074,P49721,P28072 7 Regulation of mrna stability by proteins that bind au rich elements 0.4276205009911401 1.6773464855364877 0.0934747474118871 1.0 0.6138477492383118 65 P28070,P25786,P60900,Q92945,P20618,Q01105,P28072,P31749,P28074,P49721,Q92973 11 Fgfr1 mutant receptor activation 0.6528970247957122 1.6715413787262088 0.0946147926610134 1.0 0.6138477492383118 10 P62993,Q92614,O15164,O95429,O95684 5 Collagen biosynthesis and modifying enzymes 0.6464460139703914 1.6702634994073928 0.0948672414695257 1.0 0.6138477492383118 11 P13674,Q32P28,O15460 3 Stabilization of p53 0.4697000236942311 1.6624284752640983 0.0964268933991723 1.0 0.6138477492383118 40 P28070,P25786,P20618,P28074,P49721,P28072 6 Formation of atp by chemiosmotic coupling 0.6499807659647172 1.6572954885863838 0.0974597489676381 1.0 0.6138477492383118 10 P00846 1 Apc c mediated degradation of cell cycle proteins 0.4411901176800417 1.6550034697635525 0.097923794079046 1.0 0.6138477492383118 54 P28070,P25786,P60900,P20618,P28074,Q96DE5,Q9UJX6,Q9UJX3,P49721,P28072 10 Signaling by fgfr1 in disease 0.6407466730727308 1.6419873926351878 0.1005926168719832 1.0 0.6138477492383118 11 P62993,Q92614,O15164,O95429,O95684 5 Interconversion of nucleotide di and triphosphates 0.5244221006456301 1.63870321302182 0.1012750845812302 1.0 0.6138477492383118 22 P17812,Q9H773 2 Apc cdc20 mediated degradation of nek2a 0.6460603073431066 1.6381126456779287 0.1013981975125597 1.0 0.6138477492383118 10 Q96DE5,O60566,Q9UJX6,Q9UJX3,Q16763 5 Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components 0.6460603073431066 1.6381126456779287 0.1013981975125597 1.0 0.6138477492383118 10 Q96DE5,O60566,Q9UJX6,Q9UJX3,Q16763 5 Initiation of nuclear envelope ne reformation 0.5558079444169375 1.6353465679926011 0.1019764166210477 1.0 0.6138477492383118 17 Q14739,Q86XL3 2 Cross presentation of soluble exogenous antigens endosomes 0.4720035670384296 1.6318269940737429 0.1027159369992449 1.0 0.6138477492383118 38 P28070,P25786,P20618,P28074,P49721,P28072 6 Hedgehog on state 0.4589529010872109 1.6273230651997674 0.1036685017037901 1.0 0.6138477492383118 42 P28070,P25786,P20618,P28074,P49721,P28072 6 Synthesis of pg 0.9194469492034866 1.6228360532744146 0.1046244563786298 1.0 0.6138477492383118 2 O95674 1 Pre notch processing in golgi 0.7781874751243236 1.6205629043113112 0.1051114133458217 1.0 0.6138477492383118 5 P16615,Q15363,P15291 3 Ub specific processing proteases 0.4058924420434177 1.6205157705073263 0.1051215294155913 1.0 0.6138477492383118 73 P21796,P28070,P45880,P25786,P20618,Q96FW1,P28074,P49721,P28072 9 Asymmetric localization of pcp proteins 0.4669405475153834 1.614693782182292 0.1063770247259574 1.0 0.6138477492383118 39 P28070,P25786,P60900,P20618,P28074,P49721,P28072 7 Collagen formation 0.5762593112579283 1.5992266502997394 0.1097702507557301 1.0 0.6232117462260806 14 P13674,P07858,Q32P28,O15460 4 Signaling by cytosolic fgfr1 fusion mutants 0.6618267239987132 1.5862086515404366 0.1126919858802901 1.0 0.6321526538623449 8 P62993,Q92614,O95684,O15164 4 Metabolism of polyamines 0.4617997094848026 1.5727343924209969 0.1157803327175062 1.0 0.6432907914151158 39 P28070,P25786,P20618,P28074,P49721,P28072 6 Hedgehog ligand biogenesis 0.4554364456530581 1.5704496276239093 0.1163105445489554 1.0 0.6432907914151158 41 P28070,P25786,P20618,P28074,P49721,P28072 6 Cytoprotection by hmox1 0.4082757895053391 1.55547694808508 0.1198325204983699 1.0 0.6439854536706291 69 P28070,P25786,P60900,P20618,P30519,P28074,P09601,P49721,P28072,O75880 10 Phase ii conjugation of compounds 0.4795411159370384 1.5526792552351991 0.120499780721974 1.0 0.6443616357546299 32 O15217,Q9UJ14,Q9NUJ1 3 Degradation of gli1 by the proteasome 0.4526460276575921 1.5470539436097712 0.1218502384660142 1.0 0.6474156066420683 41 P28070,P25786,P20618,P28074,P49721,P28072 6 Defective cftr causes cystic fibrosis 0.4484021996953661 1.537998444231924 0.1240489951788779 1.0 0.6517200940741071 42 P28070,P25786,P20618,P28074,P49721,P28072 6 Abc transporter disorders 0.448402199695366 1.537998444231922 0.1240489951788783 1.0 0.6517200940741071 42 P28070,P25786,P20618,P28074,P49721,P28072 6 Mastl facilitates mitotic progression 0.7571085470481644 1.534615561798824 0.1248782878285403 1.0 0.6536380269984567 5 P30154 1 Platelet sensitization by ldl 0.7280941309537796 1.530093892146032 0.1259934898894186 1.0 0.6538988254811995 6 P30154 1 Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.6483972812803394 1.523282884351952 0.1276879473355365 1.0 0.6561482841183777 8 Q16763,Q96DE5,Q9UJX6,Q9UJX3 4 Transcriptional regulation by runx3 0.4464473848425531 1.5213626197172851 0.1281688639301856 1.0 0.6562245833225506 42 P28070,P25786,P20618,P28074,P49721,P28072 6 Enos activation 0.8417162337108871 1.507356465762852 0.1317193112714272 1.0 0.663659384845578 4 P35270 1 Ras processing 0.7224888931855009 1.5066779607165155 0.131893223397308 1.0 0.663659384845578 6 O60725,P49356 2 Synaptic adhesion like molecules 0.7219713429718511 1.504514014602784 0.1324490675721643 1.0 0.663659384845578 6 P41440 1 Regulation of lipid metabolism by pparalpha 0.5075237768278555 1.4998100365635527 0.1336636167638709 1.0 0.664558780940393 21 O60244,P37268,P23786,Q15067,Q13503 5 Formyl peptide receptors bind formyl peptides and many other ligands 0.8887886985272013 1.49696867816241 0.1344014082607652 1.0 0.664558780940393 2 Q9NRV9 1 Cristae formation 0.5106459387775721 1.4952518476614431 0.1348487268095617 1.0 0.664558780940393 20 Q5XKP0,O75964,Q9NX63,P00846,Q9Y512 5 Metabolism of vitamins and cofactors 0.4433227220289227 1.494716284905395 0.1349885023785173 1.0 0.664558780940393 42 P78417,P43490,Q9H2D1,P00374,O75874,P34896,P31749,Q8N0U8,P35270,P41440,Q9BQG2 11 Scf skp2 mediated degradation of p27 p21 0.4439642697920383 1.4739253887239403 0.14050168106797 1.0 0.6845203008432587 41 P28070,P25786,P20618,P28074,P49721,P28072 6 Regulation of runx2 expression and activity 0.4369286376847252 1.4672069098254794 0.1423197778116047 1.0 0.6858003681734175 43 P28070,P25786,P20618,P28074,P49721,P28072 6 Negative regulation of mapk pathway 0.588313261537033 1.4635856729543042 0.1433071894892805 1.0 0.6858003681734175 12 P30154,P30086,P30153 3 Synthesis of dna 0.3982113807803324 1.458792399661137 0.144622255117585 1.0 0.6858003681734175 85 P28070,P25786,Q9Y619,Q9UJX3,P60900,P20618,Q9NR33,Q14181,P51530,P28074,Q9UJX6,P41440,P49721,P28072 14 Immunoregulatory interactions between a lymphoid and a non lymphoid cell 0.7380809893937735 1.4566570520496884 0.1452110706229898 1.0 0.6858003681734175 5 Q5KU26,P04439,P10321 3 Signaling by flt3 fusion proteins 0.73747235149987 1.454158240012011 0.1459024397981061 1.0 0.6858003681734175 5 P62993,Q92614 2 Striated muscle contraction 0.6714567361980852 1.4533657253320271 0.1461222375369497 1.0 0.6858003681734175 7 P06753,P67936,P08670,P09493 4 Cellular response to hypoxia 0.4404725141690257 1.4443717297121343 0.1486344385306008 1.0 0.6893965689417525 41 P28070,P25786,P20618,P28074,P49721,P28072 6 Proton coupled monocarboxylate transport 0.8746618575292989 1.4389562920399648 0.1501629068079828 1.0 0.6922366011915911 2 P35613 1 Transcriptional regulation by runx2 0.4191455732887725 1.4315099801759277 0.1522841087388426 1.0 0.6939029938650179 52 P28070,P25786,P60900,P20618,P31749,P28074,Q96PK6,P49721,P28072 9 Auf1 hnrnp d0 binds and destabilizes mrna 0.4351726866524332 1.4249022943667746 0.1541854463449854 1.0 0.6969738523238163 42 P28070,P25786,P20618,P28074,P49721,P28072 6 Dap12 interactions 0.729966333414034 1.4233183253706196 0.1546438970015078 1.0 0.6969738523238163 5 P62993,P10321 2 Gamma carboxylation hypusine formation and arylsulfatase activation 0.6077352777752063 1.4223037891151182 0.1549380793873256 1.0 0.6969738523238163 9 O60725,P38435 2 E2f mediated regulation of dna replication 0.5965468281993893 1.420158454008614 0.1555615558028495 1.0 0.6975499062751981 11 P30154,P30153,Q14181,Q9Y619 4 Retrograde transport at the trans golgi network 0.4949915798318632 1.4169177711052972 0.1565069701189214 1.0 0.6987298264440901 21 Q5VZE5,Q7Z6M1,P53365,Q96JB2,O43752 5 Metabolism of nitric oxide nos3 activation and regulation 0.663031728487838 1.4158575855682618 0.1568172053667134 1.0 0.6987298264440901 7 P35270 1 Er to golgi anterograde transport 0.3866073046525649 1.4129074717908925 0.1576829318838668 1.0 0.7003708772633581 76 Q96JB2,O15027,Q9BVK6,P18085,Q96PC5,O43731,Q15363,Q92734,P24390,Q8IUR0,P84085,Q9Y6Y8,P49257 13 Synthesis of leukotrienes lt and eoxins ex 0.8659452960625176 1.4031804334286253 0.1605630407740301 1.0 0.7050160445775834 2 Q14914 1 Cell surface interactions at the vascular wall 0.5594570122625899 1.4018705732794732 0.1609538992251462 1.0 0.7050160445775834 13 P14174,P62993,P35613 3 Endosomal vacuolar pathway 0.8108270676691745 1.38807806771638 0.1651132742863095 1.0 0.7197507436381542 4 P04439,Q9UIQ6,P10321 3 Mapk family signaling cascades 0.3967843566683857 1.380901438514197 0.1673092676001883 1.0 0.7263367935053346 92 P28070,P25786,P30154,P60900,P20618,P49356,O43924,P30086,P28074,P30153,Q14168,P07196,O60725,P28482,P49721,P28072 16 Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.5052493716918807 1.379775218631113 0.167655864978149 1.0 0.7263367935053346 18 Q02818,Q07065,Q9BTY2,P11047 4 Ripk1 mediated regulated necrosis 0.5873515490837531 1.373494074098447 0.1695988021968113 1.0 0.7302602859116525 11 P49327,P41440 2 Pp2a mediated dephosphorylation of key metabolic factors 0.8956593583182051 1.371413963626983 0.1702459469972357 1.0 0.730650343626168 3 P30154 1 Egr2 and sox10 mediated initiation of schwann cell myelination 0.6150038505520744 1.3654575292783198 0.1721092929661591 1.0 0.730650343626168 8 Q16850,Q9NR77 2 Collagen degradation 0.8545235948301795 1.356343567933741 0.1749898793997719 1.0 0.7332909231990443 2 P07858 1 Tnfr2 non canonical nf kb pathway 0.4259105901953144 1.3450307326444788 0.1786153101236576 1.0 0.7440543096275442 42 P28070,P25786,P20618,P28074,P49721,P28072 6 Dectin 1 mediated noncanonical nf kb signaling 0.4259105901953144 1.3450307326444788 0.1786153101236576 1.0 0.7440543096275442 42 P28070,P25786,P20618,P28074,P49721,P28072 6 Tcf dependent signaling in response to wnt 0.3991144570803667 1.340914013055957 0.1799483719847041 1.0 0.745197963983716 62 P28070,P25786,P30154,P60900,P20618,P31749,P28074,P30153,P49721,P28072 10 Intra golgi traffic 0.5211539174212563 1.327305013364862 0.1844078061289875 1.0 0.7521627031387428 15 Q96JB2,O43752,O95721,O00461 4 Vitamin d calciferol metabolism 0.8811895194680883 1.3175828469344768 0.1876433307975387 1.0 0.7536787951412471 3 P04062 1 Uch proteinases 0.4127660904621072 1.3107652919551478 0.1899370720361326 1.0 0.7543280076048999 45 P28070,P25786,P20618,P28074,Q8NB78,P49721,P28072 7 Disassembly of the destruction complex and recruitment of axin to the membrane 0.5831030627510476 1.3006561692451015 0.1933761714800956 1.0 0.7543280076048999 9 P30154,P30153 2 Transport of small molecules 0.4230450804167072 1.3003372155111423 0.1934854182081642 1.0 0.7543280076048999 145 P28070,P25786,Q9UBX3,P12235,P30519,Q9HD20,Q8WTV0,Q9NQ11,O15118,P28074,Q9Y487,Q8WWC4,Q70HW3,P53985,Q93050,P60900,P20618,P09601,P49721,P28072,P21796,P08183,P45880,Q9BUN8,Q96TA2,Q9BU23,P35613,P02786,Q96QD8,P16615 30 Platelet aggregation plug formation 0.6710274741643452 1.2902093909207932 0.196977966449287 1.0 0.7543280076048999 6 P46108,P31749 2 Integrin signaling 0.6710274741643452 1.2902093909207932 0.196977966449287 1.0 0.7543280076048999 6 P46108,P31749 2 Smac xiap regulated apoptotic response 0.8379921851517733 1.2886846544793078 0.1975077395209705 1.0 0.7543280076048999 2 Q9NR28 1 Keratan sulfate biosynthesis 0.8373910429816522 1.2862281368293011 0.198363454082123 1.0 0.7543280076048999 2 O43505 1 Phospholipid metabolism 0.4098816054431516 1.284742194457259 0.1988823882836379 1.0 0.7543280076048999 45 P48651,Q96N66,Q99829,Q9NPH0,Q8IV08,Q9UBF8,P43304,P67870,Q8NCC3,O15228,P42356,P35790,Q9NQZ5,O95674 14 Abc family proteins mediated transport 0.4046908682575409 1.2831832673365495 0.1994278767633965 1.0 0.7543280076048999 50 P08183,P28070,P25786,P60900,P20618,Q9BUN8,P28074,P49721,P28072 9 Pcp ce pathway 0.404597398245032 1.2773099592510897 0.2014928389269741 1.0 0.7543280076048999 49 P28070,P25786,P60900,P20618,P28074,P49721,P28072 7 Signaling by ctnnb1 phospho site mutants 0.5963838388008063 1.276747628728105 0.2016913603822931 1.0 0.7543280076048999 8 P30154 1 Beta catenin phosphorylation cascade 0.5963838388008063 1.276747628728105 0.2016913603822931 1.0 0.7543280076048999 8 P30154 1 Alpha oxidation of phytanate 0.7819095280086266 1.2762366328298644 0.2018718826500933 1.0 0.7543280076048999 4 Q9BY49 1 Platelet homeostasis 0.5721787230802928 1.2705830387442083 0.2038770241554295 1.0 0.7551396987087367 10 P30154,P30153,Q16539,P16615,Q16537 5 The role of gtse1 in g2 m progression after g2 checkpoint 0.4026716242305845 1.2642359617218784 0.2061453468106424 1.0 0.7551396987087367 50 P28070,P25786,P20618,P28074,P49721,P28072 6 Runx1 regulates transcription of genes involved in differentiation of hscs 0.4164862244333699 1.2632093795139068 0.2065139429231015 1.0 0.7551396987087367 42 P28070,P25786,P20618,P28074,P49721,P28072 6 Dna replication pre initiation 0.3876259685964412 1.2512172938851946 0.2108552103550893 1.0 0.7551396987087367 64 P28070,P25786,Q9Y619,P60900,P20618,Q9NR33,P28074,P49721,P28072 9 Fceri mediated nf kb activation 0.4061540018146253 1.251033621256108 0.2109222112633939 1.0 0.7551396987087367 45 P28070,P25786,P20618,P28074,P49721,P28072 6 Signaling by fgfr in disease 0.4696313853169913 1.2474912885939988 0.2122174124688367 1.0 0.7551396987087367 21 P62993,Q92614,P19388,O15164,O95429,O95684 6 Signaling by notch 0.3893994880711754 1.241881797691012 0.2142801768986713 1.0 0.7580565052093698 62 P28070,P25786,P78536,P60900,O75832,P20618,Q99436,P31749,P28074,Q15363,P67809,P16615,P49721,P28072,P15291 15 Ire1alpha activates chaperones 0.4474002878896818 1.2351753538198873 0.2167652497300136 1.0 0.7590155062241741 27 O43909,P43307,O43731,Q9NWM8 4 Caspase activation via death receptors in the presence of ligand 0.8247670574090753 1.2347190566677388 0.2169350810312655 1.0 0.7590155062241741 2 P49327 1 Regulation by c flip 0.8247670574090753 1.2347190566677388 0.2169350810312655 1.0 0.7590155062241741 2 P49327 1 Copi dependent golgi to er retrograde traffic 0.3969394409140203 1.2278971497189808 0.2194855796318295 1.0 0.7590155062241741 53 Q9BVK6,P18085,Q9P2W9,Q02224,O43731,Q15363,P84085,P24390 8 Antigen presentation folding assembly and peptide loading of class i mhc 0.5113816647355728 1.227720181999987 0.219552027581231 1.0 0.7590155062241741 14 Q9NZ08,P04439,Q03518,P10321 4 Ion transport by p type atpases 0.5679106796563065 1.2251877185317686 0.2205045007590733 1.0 0.7590155062241741 9 Q9NQ11,Q9HD20 2 Regulation of tp53 expression and degradation 0.5580042083257318 1.2235999334557333 0.2211031847329212 1.0 0.7590155062241741 11 P30154,P30153 2 Cargo concentration in the er 0.5266922722767197 1.2207531229767954 0.2221795074270678 1.0 0.7590155062241741 13 Q96PC5,Q12907,P49755,Q15363,P49257 5 S phase 0.3856374331970735 1.2202051329211028 0.2223871215425927 1.0 0.7590155062241741 96 P28070,P25786,Q9Y619,Q9UJX3,P60900,P20618,Q9NR33,Q14181,P31749,P51530,P28074,Q9UJX6,P41440,P49721,P28072 15 Pyruvate metabolism and citric acid tca cycle 0.4315762537601511 1.2195451218040083 0.2226373608455851 1.0 0.7590155062241741 34 P21796,O95563,P48735,P35613 4 Unblocking of nmda receptors glutamate binding and activation 0.6784083768273073 1.2106963443437435 0.2260118039797358 1.0 0.7622185531535711 5 Q14168 1 Ras activation upon ca2 influx through nmda receptor 0.6784083768273073 1.2106963443437435 0.2260118039797358 1.0 0.7622185531535711 5 Q14168 1 Long term potentiation 0.6784083768273073 1.2106963443437435 0.2260118039797358 1.0 0.7622185531535711 5 Q14168 1 Fgfr2 alternative splicing 0.4865134515520085 1.210589202240707 0.2260528846090608 1.0 0.7622185531535711 17 P31943,P52597,Q01085,P09651 4 Mapk6 mapk4 signaling 0.3967256006918476 1.2082835476703515 0.2269382146214884 1.0 0.7622185531535711 50 P28070,P25786,P20618,P28074,P49721,P28072 6 Gene and protein expression by jak stat signaling after interleukin 12 stimulation 0.4484207856287172 1.202063130832196 0.2293390695839114 1.0 0.7623326804343953 25 P14174,P78417,P22626,P11233,O14979,Q13126 6 Transport to the golgi and subsequent modification 0.3718661798761572 1.1986417080285818 0.2306672931514999 1.0 0.7623326804343953 81 Q8IUR0,Q9Y6Y8,O15027,Q9BVK6,P18085,Q96PC5,Q15363,O43731,Q92734,Q96JB2,O60476,P84085,P24390,P49257 14 Resolution of d loop structures through synthesis dependent strand annealing sdsa 0.6139912908856291 1.1960714148858549 0.2316686914830712 1.0 0.7623326804343953 7 Q9UQ84 1 Resolution of d loop structures 0.6139912908856291 1.1960714148858549 0.2316686914830712 1.0 0.7623326804343953 7 Q9UQ84 1 Interleukin 12 signaling 0.4412791817857351 1.1901513079225026 0.2339869271832964 1.0 0.7635393010355018 27 P14174,P78417,P22626,P11233,O14979,Q13126 6 Synthesis of very long chain fatty acyl coas 0.576784139331066 1.1829699054891023 0.236821074654141 1.0 0.7668754308293029 8 Q9P035,Q9NZ01 2 Erks are inactivated 0.6454700698594521 1.1820423134852276 0.2371889117983334 1.0 0.7668754308293029 6 P30154,P30153 2 Cellular response to chemical stress 0.368369157497834 1.177866091764897 0.2388499949912297 1.0 0.7668754308293029 79 P28070,P25786,P60900,P20618,P30519,P28074,P09601,P49721,P28072,O75880 10 Phosphorylation of the apc c 0.5490407708549633 1.1775800998904111 0.2389640471871978 1.0 0.7668754308293029 11 Q9UJX4,Q96DE5,Q9UJX6,Q9UJX3,Q16763 5 Regulation of glycolysis by fructose 2 6 bisphosphate metabolism 0.7524780562826037 1.162570487988538 0.2450038103781513 1.0 0.7704953571589979 4 P30154 1 Apc c cdc20 mediated degradation of cyclin b 0.547771770295508 1.147220734105309 0.2512904043688784 1.0 0.7815184351890774 10 Q16763,Q96DE5,Q9UJX6,Q9UJX3 4 Methylation 0.568562832485095 1.1435484410086638 0.2528109544803594 1.0 0.7815184351890774 8 P78417,P21964 2 Tnf signaling 0.5457391559550735 1.136921120039171 0.2555712621962964 1.0 0.7815184351890774 10 O95429,O15111,P78536,Q8TCT8 4 Inhibition of replication initiation of damaged dna by rb1 e2f1 0.6346658485479747 1.136273807186864 0.2558419893432626 1.0 0.7815184351890774 6 P30154,P30153,Q14181 3 Interleukin 12 family signaling 0.4269611011607056 1.1195204695113974 0.2629181632661295 1.0 0.7815184351890774 30 P14174,P78417,P22626,P11233,O14979,Q13126 6 Extracellular matrix organization 0.4225877151125421 1.1145425736486378 0.2650464908029013 1.0 0.7815184351890774 32 Q32P28,P11047,P78536,P13674,P07858,O75718,O15460,P35613 8 Glycosaminoglycan metabolism 0.4783132416351052 1.1142595448907655 0.2651678569879376 1.0 0.7815184351890774 16 O43505,Q7LGA3,Q8NCH0,P54802,P15291,P08236 6 Tcr signaling 0.3865698485745374 1.1122042567879349 0.2660503380861103 1.0 0.7815184351890774 50 P28070,P25786,P20618,P28074,P49721,P28072 6 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0.7392036837174847 1.1114680107892625 0.2663669520203802 1.0 0.7815184351890774 4 P12235,P36404 2 Deadenylation dependent mrna decay 0.4010693178106215 1.1057622938040237 0.2688294193630836 1.0 0.7815184351890774 41 Q969T7,Q6PGP7,P06730 3 Negative regulation of nmda receptor mediated neuronal transmission 0.6265849632172984 1.1020480585802483 0.2704407788899212 1.0 0.7815184351890774 6 Q14168 1 N glycan trimming and elongation in the cis golgi 0.7920048091373555 1.101982665783539 0.270469207664695 1.0 0.7815184351890774 2 O60476 1 Nicotinate metabolism 0.7351926293723677 1.0960568497880785 0.2730538965212528 1.0 0.7815184351890774 4 P43490 1 Intra golgi and retrograde golgi to er traffic 0.3791273585935242 1.0949726365544874 0.2735286246375972 1.0 0.7815184351890774 102 Q9P2W9,P18085,Q9BVK6,Q5VZE5,Q7Z6M1,P20645,O00461,Q02224,P53365,Q15363,O43731,O60476,Q13561,Q96JB2,O43752,O95721,P84085,P24390 18 Response to elevated platelet cytosolic ca2 0.4170592046559103 1.0868772085389198 0.2770910800616746 1.0 0.786627982266201 33 Q9NTK5,O94919,P07602,Q9NUQ9,Q8NBX0 5 Complement cascade 0.7880973850315587 1.0862706762983996 0.2773592564875002 1.0 0.786627982266201 2 P10909 1 Interleukin 1 signaling 0.3841723535228503 1.0855767983768525 0.277666269308453 1.0 0.786627982266201 49 P28070,P25786,P20618,P28074,P49721,P28072 6 Ros and rns production in phagocytes 0.556043970219003 1.0834663123619672 0.2786014957811784 1.0 0.7876925824495968 8 Q9Y487 1 Glycogen storage diseases 0.7302255639097761 1.0769954161659387 0.2814823135260031 1.0 0.7909331829362596 4 P10253,Q04446,P46976 3 Neddylation 0.3575717959146423 1.0736760707461117 0.2829678899174588 1.0 0.7909331829362596 77 P28070,Q5TAQ9,P25786,P20618,Q9BTE7,P28074,O94888,P49721,P28072 9 Insulin receptor recycling 0.5369058947913582 1.070489897589615 0.2843988538662745 1.0 0.7909331829362596 9 Q9Y487 1 Signaling by interleukins 0.3852180630555883 1.0694157892254224 0.28488235578268 1.0 0.7909331829362596 114 P14174,P28070,P25786,P30154,P28074,P30153,P60900,P20618,P09601,P49721,P28072,P78417,P22626,P11233,O14979,P31749,P52597,Q13126,P46108,P04083,P28482,P08670 22 P38mapk events 0.7823865344153749 1.0633628412940652 0.2876174371496136 1.0 0.7909331829362596 2 P11233 1 Negative regulation of the pi3k akt network 0.4764063856351728 1.0614999600610522 0.2884627510546085 1.0 0.7909331829362596 15 P30154,P31749,P30153,P28482 4 Deubiquitination 0.3701648794024236 1.06031998243914 0.2889990514396177 1.0 0.7909331829362596 94 P21796,P28070,P45880,P25786,P20618,Q96FW1,P54725,P28074,Q8NB78,P49721,P28072 11 Diseases of dna repair 0.5289528926442868 1.0517732751367448 0.2929035831474524 1.0 0.7909331829362596 10 Q9UQ84 1 Dna replication 0.3661558956855192 1.0408551119268987 0.2979427974330702 1.0 0.7909331829362596 91 P28070,P25786,Q9Y619,Q9UJX3,P60900,P20618,Q9NR33,Q14181,P51530,P28074,Q9UJX6,P41440,P49721,P28072 14 Cyclin a b1 b2 associated events during g2 m transition 0.52207624361547 1.038733972358598 0.2989284767576685 1.0 0.7909331829362596 11 P30154 1 Mitochondrial biogenesis 0.4017662359276125 1.0352929102281947 0.3005321398230816 1.0 0.7909331829362596 37 Q5XKP0,Q04837,Q9BUR5,O75964,Q9NX63,P48735,P00846,Q9Y512,Q96RS0 9 Transcriptional regulation by mecp2 0.4707745366934094 1.027857933245063 0.3040166600053722 1.0 0.7932797668065923 15 Q14739,Q13451 2 Tp53 regulates transcription of cell death genes 0.6072918591826397 1.020433341900532 0.3075229877441476 1.0 0.7988789054312914 6 P49327 1 Peroxisomal lipid metabolism 0.5171674004651381 1.013425340573748 0.3108570405328561 1.0 0.8031907163452606 11 Q9BY49,Q5T8D3,Q15067 3 Interferon alpha beta signaling 0.5208906712223451 1.010850939043996 0.3120877784701972 1.0 0.8031907163452606 10 P01889,P04439,P10321 3 Copii mediated vesicle transport 0.4141661324739594 0.999077171609802 0.3177573088364811 1.0 0.8090457338910767 28 O15027,Q15363,Q8IUR0,Q9Y6Y8,P49257 5 Trna modification in the nucleus and cytosol 0.4589362392320075 0.9958114837725648 0.3193417495170187 1.0 0.8101498798557881 16 Q96PZ0,Q5VV42,O75648 3 Apoptotic factor mediated response 0.5371342608939917 0.9927045858404476 0.320853939472485 1.0 0.8103247793518226 8 P28482,P42574,Q9NR28,P42771 4 Aberrant regulation of mitotic exit in cancer due to rb1 defects 0.5198774417480962 0.9853792612600992 0.3244378126207299 1.0 0.8128264059964193 9 Q16763,Q96DE5,Q9UJX6,Q9UJX3 4 Noncanonical activation of notch3 0.7616471295461205 0.980810533624582 0.3266861827773948 1.0 0.8155569953024324 2 P67809 1 Selective autophagy 0.3969299129057335 0.9759216996255716 0.3291032678644821 1.0 0.8167894882538567 36 P21796,Q9NS69,O95140,P08670,Q8N4H5 5 Copi mediated anterograde transport 0.3689856850825234 0.9756149377897434 0.3292553192321172 1.0 0.8167894882538567 56 Q9BVK6,P18085,Q15363,O43731,Q96JB2,P24390 6 Beta catenin independent wnt signaling 0.3701161672484454 0.9737654062678278 0.3301730332632049 1.0 0.8167894882538567 54 P28070,P25786,P60900,P20618,P28074,P49721,P28072 7 Signaling by ntrk2 trkb 0.6192270049797177 0.9671295615288952 0.3334792691774666 1.0 0.8167894882538567 5 P62993 1 Rnd1 gtpase cycle 0.4472170523213147 0.964830440864226 0.3346297462262544 1.0 0.8167894882538567 17 P02786,Q9BXS4,P51648,P38159,O75976 5 Signalling to ras 0.7826217678893479 0.9550813630953096 0.3395365529201966 1.0 0.8256778350805472 3 P62993,P11233 2 Nicotinamide salvaging 0.7752609840986655 0.92859236903531 0.3531003780510047 1.0 0.8398063045537408 3 P43490 1 Caspase activation via extrinsic apoptotic signalling pathway 0.6086735327799321 0.9240884918877548 0.3554402444774855 1.0 0.8414180833516418 5 P49327,P42574 2 Diseases of glycosylation 0.4335463721212413 0.921667743022394 0.3567019110733496 1.0 0.8414180833516418 18 Q06210,O43505,Q8NCH0,P10619,O75340 5 Clec7a dectin 1 signaling 0.3642476989891615 0.8991761059386426 0.3685588653556289 1.0 0.8491866697708841 50 P28070,P25786,P20618,P28074,P49721,P28072 6 Signaling by fgfr2 0.4095993727806228 0.8989636003018752 0.3686720492478272 1.0 0.8491866697708841 24 P31943,P62993,P52597,P30153,P09651,P28482,Q01085 7 Signaling by fgfr 0.4095993727806228 0.8989636003018752 0.3686720492478272 1.0 0.8491866697708841 24 P31943,P62993,P52597,P30153,P09651,P28482,Q01085 7 Unfolded protein response upr 0.3686240549821016 0.883838553162695 0.3767833713021453 1.0 0.8491866697708841 44 Q06210,O43731,Q9NWM8,O43909,P43307 5 Met promotes cell motility 0.4975082517660726 0.8737897140631352 0.3822327830354275 1.0 0.8491866697708841 9 P46108,P11047 2 Hdr through homologous recombination hrr 0.3993941076531432 0.8721131680902968 0.3831466431367163 1.0 0.8491866697708841 26 Q9UQ84,Q9NR33,O14757,P41440,P51530 5 Signaling by insulin receptor 0.4446913936699437 0.8720114842474207 0.3832021124923148 1.0 0.8491866697708841 15 P28482,Q93050,Q9Y487 3 Fc epsilon receptor fceri signaling 0.3591511294564616 0.8714250227053407 0.3835221279760306 1.0 0.8491866697708841 55 P28070,P25786,P60900,P20618,P28074,P28482,P49721,P28072 8 Hedgehog off state 0.3594836524822954 0.8692109303474584 0.3847317699862258 1.0 0.8491866697708841 54 P28070,P25786,P20618,P28074,P49721,P28072 6 O linked glycosylation of mucins 0.6744324151263548 0.8655086264131893 0.3867596832675337 1.0 0.8491866697708841 4 O43505 1 O linked glycosylation 0.6744324151263548 0.8655086264131893 0.3867596832675337 1.0 0.8491866697708841 4 O43505 1 Rhog gtpase cycle 0.3775637340555155 0.8639586162974403 0.3876106246456625 1.0 0.8491866697708841 39 Q13576,P02786,Q86XL3,P34897,O15173,P49257,Q14739,P50402 8 Regulation of mecp2 expression and activity 0.487291889351065 0.8596028449787307 0.390008006231247 1.0 0.8491866697708841 11 Q14739 1 Myoclonic epilepsy of lafora 0.7297865945295994 0.8564752446686955 0.3917349600792741 1.0 0.8491866697708841 2 P46976 1 Basigin interactions 0.5676249788706201 0.8537978072896589 0.3932170296406454 1.0 0.8491866697708841 6 P35613 1 Antigen processing ubiquitination proteasome degradation 0.3499574254164792 0.8352724179509995 0.4035643435091307 1.0 0.8562244796939472 93 P19474,P28070,P25786,Q8IWV7,P20618,P60900,Q9UIQ6,P55786,P28074,Q9UJX6,Q9UJX3,P49721,P28072 13 Rac3 gtpase cycle 0.3776501412277614 0.8334829377395582 0.404572416667929 1.0 0.8562244796939472 37 Q14739,Q9UQB8,O15173 3 Cyclin d associated events in g1 0.4892444422875579 0.8327177902922741 0.4050039087188699 1.0 0.8562244796939472 9 P30154 1 Interaction between l1 and ankyrins 0.6643336693726601 0.827960813012573 0.4076926929099915 1.0 0.858104949287002 4 Q13813,O15020 2 Regulation of tnfr1 signaling 0.5319567732865794 0.8279095240193369 0.4077217408188951 1.0 0.858104949287002 7 O15111,Q8TCT8 2 Signalling to erks 0.4871053201195928 0.8221058235228841 0.4110166713973864 1.0 0.8600899472827115 9 P46108,P28482,P11233 3 Heme signaling 0.5011715795712579 0.8208719789224392 0.4117191935145934 1.0 0.8600899472827115 8 P09601,Q96RS0 2 Transferrin endocytosis and recycling 0.4819690854862068 0.8138254820308959 0.4157449348858131 1.0 0.8650564478161402 10 Q93050,Q9Y487 2 Recycling of eif2 gdp 0.52528597230585 0.7983459466069642 0.4246697616526833 1.0 0.8786687626000137 7 P05198,Q9UI10,Q13144,P20042,Q9NR50,P49770 6 Ion channel transport 0.3913560070705141 0.7900719686974754 0.4294857392587676 1.0 0.880226959063093 25 Q93050,Q9HD20,Q9Y487 3 Activation of gene expression by srebf srebp 0.406175219006273 0.7880025885931925 0.4306951917400139 1.0 0.8802902813692574 19 P48449,Q16850,Q9UBM7,P37268 4 Interleukin 1 family signaling 0.3511140097269564 0.7866949015654419 0.4314604893761857 1.0 0.8802902813692574 54 P28070,P25786,P20618,P28074,P49721,P28072 6 Synthesis of pc 0.5743445495693594 0.7857440334789776 0.4320174605299409 1.0 0.8802902813692574 5 P35790,Q9NQZ5 2 Ptk6 regulates proteins involved in rna processing 0.7294046903186846 0.7668834501432941 0.4431508143534173 1.0 0.8913662094423023 3 O75525,Q07666 2 The citric acid tca cycle and respiratory electron transport 0.3500293985841034 0.765814510378426 0.443786679056809 1.0 0.8913718175634624 101 P21796,P35613,O43676,P20674,O75964,Q9UDW1,O75306,Q9NPL8,O75438,O95168,P48735,Q86Y39,P00846,Q16134,Q15120,O75880,O95563,O14949 18 Metabolism of water soluble vitamins and cofactors 0.3748666603863634 0.7639783129250759 0.4448801665903934 1.0 0.8922952629049486 34 P78417,P43490,Q9H2D1,P00374,P34896,P41440,Q9BQG2 7 G2 m checkpoints 0.3371827261924928 0.7510657800608036 0.4526130688089396 1.0 0.898842314362464 86 Q9UQ84,P28070,P25786,Q9Y619,P60900,P20618,P51530,P28074,P49721,P28072 10 Activated notch1 transmits signal to the nucleus 0.7236921226698645 0.7472261478007161 0.4549270630420503 1.0 0.9021652179763476 3 Q92542,P78536 2 Cytochrome c mediated apoptotic response 0.6417991285526942 0.7453355809226236 0.4560688764835878 1.0 0.9031574937959096 4 P28482,Q9NR28 2 Regulation of cholesterol biosynthesis by srebp srebf 0.3836937867277377 0.7347560763122316 0.4624880618889948 1.0 0.9087476062438782 25 P48449,Q16850,Q9UBM7,P37268 4 Disorders of transmembrane transporters 0.325718641927923 0.7347354908424286 0.4625006011981407 1.0 0.9087476062438782 74 P28070,P25786,P20618,P28074,Q9BTX1,P49721,P28072,P35613 8 Rnd2 gtpase cycle 0.4019357979972039 0.7190965700368633 0.4720814205377597 1.0 0.9087476062438782 18 Q07065,P02786,P51648,P38159,Q9Y2I1 5 Organelle biogenesis and maintenance 0.3496202642341423 0.7187721171146692 0.4722813402401107 1.0 0.9087476062438782 106 Q04837,Q96CS2,Q86X55,P30153,Q99996,P48735,A6NIH7,P00846,Q9H6D7,Q92973,P78371,O95684,Q68CZ6,P18085,Q9BUR5,A0AVF1,P00367,O95613,Q9NX63,Q13561,Q9Y512,Q96RS0,Q5XKP0,O75964,O43924,O00471,O43805,P48643 28 Cd28 co stimulation 0.4764477452978664 0.7042570063795283 0.4812727356421571 1.0 0.9087476062438782 8 P31749,P62993 2 Translocation of slc2a4 glut4 to the plasma membrane 0.3573243809221501 0.6903283360628064 0.4899877322350288 1.0 0.9087476062438782 39 O60343,P31749,Q9UIQ6 3 Transcriptional regulation by ventx 0.4185466798005144 0.6874074452710167 0.491826007195896 1.0 0.9087476062438782 14 Q9UJX4,Q96DE5,Q9HCE1,Q9UJX6,Q9UJX3,Q16763 6 Signaling by wnt in cancer 0.4560375642223674 0.6841095533153403 0.4939059897592188 1.0 0.9087476062438782 10 P30154 1 Rhod gtpase cycle 0.3715851134082813 0.6791822721911094 0.4970223784808545 1.0 0.9087476062438782 28 Q14739,O15173 2 Signaling by pdgf 0.4968078249335536 0.6736240428414059 0.5005503636294768 1.0 0.9087476062438782 7 P46108 1 Downstream signal transduction 0.4968078249335536 0.6736240428414059 0.5005503636294768 1.0 0.9087476062438782 7 P46108 1 Assembly and cell surface presentation of nmda receptors 0.4479773623764218 0.6595022125958645 0.5095733257301469 1.0 0.9087476062438782 11 Q14168 1 C type lectin receptors clrs 0.3381047300115526 0.6583570272322055 0.5103087417018215 1.0 0.9087476062438782 54 P28070,P25786,P20618,P28074,P49721,P28072 6 Transport of bile salts and organic acids metal ions and amine compounds 0.6159295787051282 0.6529279497281317 0.5138027292277818 1.0 0.9087476062438782 4 P35613 1 Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux 0.5397333305847878 0.6501378807202864 0.5156031622797626 1.0 0.9087476062438782 5 Q8NB78,Q9HCE1 2 Fatty acyl coa biosynthesis 0.401838840710532 0.6482736120300931 0.5168079981687885 1.0 0.9087476062438782 16 P50897,P49327,Q9UMR5,Q9NZ01 4 Pten regulation 0.3321552608108856 0.6468451884603057 0.5177321429287369 1.0 0.9087476062438782 62 P28070,P25786,P60900,O75832,P20618,Q99436,P31749,Q9Y2Q5,P28074,Q9HCE1,P28482,P49721,P28072 13 Degradation of the extracellular matrix 0.433940369654378 0.6420789597945533 0.5208219163677734 1.0 0.9087476062438782 12 P17655,P78536,P11047,P07858,P42574,P35613 6 Constitutive signaling by akt1 e17k in cancer 0.4880120632013021 0.6357268751687072 0.5249544563675925 1.0 0.9087476062438782 7 P31749 1 Activation of rac1 downstream of nmdars 0.6693718064322232 0.6330721260031636 0.5266865437882553 1.0 0.9087476062438782 2 Q14012 1 Nef and signal transduction 0.6693718064322162 0.6330721260031381 0.526686543788272 1.0 0.9087476062438782 2 Q13177 1 Transport of vitamins nucleosides and related molecules 0.5136099465096391 0.6328928552918882 0.5268036138116936 1.0 0.9087476062438782 6 P12235,P36404 2 Map2k and mapk activation 0.4453240716407732 0.6312022937871627 0.5279082623645555 1.0 0.9087476062438782 10 P28482,P30086 2 Diseases associated with glycosaminoglycan metabolism 0.5334779698655268 0.6261984098314268 0.531184810112677 1.0 0.9087476062438782 5 Q8NCH0 1 Class i mhc mediated antigen processing presentation 0.3492185440058656 0.625532681509251 0.531621505744676 1.0 0.9087476062438782 117 P19474,P28070,P25786,P10321,Q9UJX3,Q8IWV7,P20618,Q9UIQ6,Q03518,P55786,P28074,Q9UJX6,Q9NZ08,P49721,P28072 15 Activation of smo 0.6645626690712318 0.6162151255549349 0.537752546891479 1.0 0.9111378893179332 2 P48729 1 Diseases associated with n glycosylation of proteins 0.528009642798636 0.6054406691812673 0.5448862355005213 1.0 0.9155129111989664 5 O75340,Q13724,P15291 3 Rnd3 gtpase cycle 0.3776960345624982 0.6021829876898817 0.5470523386026727 1.0 0.915623999284426 19 Q07065,Q9Y2I1,P38159 3 Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 0.320699122971204 0.5991706782030227 0.5490590738225727 1.0 0.915623999284426 69 Q8N183,O43676,P20674,O75964,Q9Y6M9,Q9NPL8,Q9UDW1,O75306,O75438,O95168,Q16134,Q86Y39,P00846,O75880,O14949 15 Signaling by hedgehog 0.328190195045433 0.5902287183504983 0.5550373210337609 1.0 0.915623999284426 60 P28070,P25786,P20618,P28074,P49721,P28072 6 Dna damage reversal 0.5234657039711075 0.5883196092216509 0.5563177859614452 1.0 0.915623999284426 5 Q9C0B1,Q9H1I8,Q8N3C0,Q6P6C2 4 Cargo trafficking to the periciliary membrane 0.3675572128050557 0.5850925484895655 0.5584854889671353 1.0 0.915623999284426 23 P18085,O43924,O00471,A6NIH7,P48643 5 Erk mapk targets 0.4378010821346668 0.5813793875212268 0.5609847864811548 1.0 0.915623999284426 9 P30154,P30153 2 Mapk targets nuclear events mediated by map kinases 0.4378010821346668 0.5813793875212268 0.5609847864811548 1.0 0.915623999284426 9 P30154,P30153 2 Akt phosphorylates targets in the cytosol 0.4995916062739166 0.5775038058701563 0.563599168386987 1.0 0.915623999284426 6 P31749 1 Synthesis of substrates in n glycan biosythesis 0.3844352263053896 0.5746198696710332 0.5655484109973083 1.0 0.915623999284426 17 P10619,Q86YN1,Q9Y5P6 3 Platelet calcium homeostasis 0.6707757065544068 0.5721631655865278 0.5672114392862828 1.0 0.915623999284426 3 P16615,P30626 2 Reduction of cytosolic ca levels 0.6707757065544068 0.5721631655865278 0.5672114392862828 1.0 0.915623999284426 3 P16615,P30626 2 Acyl chain remodelling of pg 0.6513375413285267 0.5707213365060497 0.5681885532064044 1.0 0.915623999284426 2 Q92604 1 Carnitine metabolism 0.4972700375582454 0.5684337293853032 0.5697404928985319 1.0 0.915623999284426 6 O43772 1 Cilium assembly 0.3176796548242335 0.5656750509022797 0.5716146984169108 1.0 0.915623999284426 69 P18085,O95613,P48643,Q96CS2,A0AVF1,O43924,Q13561,P30153,Q99996,O00471,A6NIH7,O43805,Q9H6D7,Q92973,P78371,O95684,Q68CZ6 17 Met activates rap1 and rac1 0.4947671313598972 0.5586903931973374 0.5763730368460245 1.0 0.9160047606455112 6 P46108 1 G alpha i signalling events 0.3557621134146377 0.5530211482388935 0.5802489289147919 1.0 0.9166563058144124 26 P30154,P07602,P04083,P30153,Q9NRV9 5 Formation of apoptosome 0.6610270613591128 0.5415699080200966 0.588114826569162 1.0 0.9184067141881676 3 Q9NR28 1 Fcgamma receptor fcgr dependent phagocytosis 0.351575816098489 0.5357405933799355 0.5921378444546386 1.0 0.9232891306668118 29 P46108,P28482,Q8IV08,Q9UQB8 4 Rhoc gtpase cycle 0.3473449257373482 0.5331537954534895 0.5939271227209564 1.0 0.924778616327576 33 Q14739,P41440 2 Nr1h2 and nr1h3 mediated signaling 0.4575242646536214 0.5075478234008696 0.611770489860713 1.0 0.9335541738469246 7 P49327,Q8NB78,Q9HCE1 3 Intrinsic pathway for apoptosis 0.3596843380437467 0.5061655912847388 0.6127404079988028 1.0 0.9335541738469246 21 Q9NR28,P31749,P42771,P28482,P42574 5 Parasite infection 0.3596698133665332 0.4958158188310927 0.6200243630823472 1.0 0.9346834081583992 20 P46108,P28482,Q9UQB8 3 Sulfur amino acid metabolism 0.41543844458654 0.486868649354042 0.6263514172047615 1.0 0.9409067652350472 10 Q13126 1 Diseases associated with glycosylation precursor biosynthesis 0.4278580376592774 0.4828255036123269 0.6292196406241937 1.0 0.9434944132043288 8 P10619 1 Rho gtpases activate ktn1 0.4165703830608948 0.4814322924327374 0.6302092902933674 1.0 0.9439730646096396 9 P84095,Q07866,Q9NSK0,Q9H0B6 4 Separation of sister chromatids 0.3308917676402702 0.4748822355453859 0.6348709139824544 1.0 0.9442322847098334 109 P28070,P25786,P30154,O75832,P28074,P30153,Q9UJX6,Q96EA4,P60900,P20618,O43683,Q02224,Q96DE5,Q9H900,Q8NBT2,P49721,P28072,Q99436,O60566,Q16763,Q9UJX4,Q9UJX3,Q53HL2 23 Signaling by moderate kinase activity braf mutants 0.400842641419338 0.4723231568645931 0.6366961439380514 1.0 0.9442322847098334 12 P30086 1 Rac2 gtpase cycle 0.3341933809723206 0.4709417331900071 0.6376823446528057 1.0 0.9442322847098334 37 Q14739,Q86XL3,O15173 3 Estrogen dependent nuclear events downstream of esr membrane signaling 0.4905064478442604 0.4681579073385298 0.6396716710070189 1.0 0.9442322847098334 5 P31749 1 Raf activation 0.4089126033389316 0.4672901692778632 0.6402922889292855 1.0 0.9442322847098334 11 P30154 1 Signaling by wnt 0.3090459238172138 0.4333101715415844 0.6647894496294047 1.0 0.9662706925586684 85 P28070,P25786,P30154,P60900,P20618,P31749,P28074,P30153,P49721,P28072 10 Signaling by vegf 0.3361953869159604 0.4155596118169472 0.6777322858121353 1.0 0.9725905791696704 27 P31749,Q9UQB8 2 Apoptosis 0.3145429942850241 0.4139905698881422 0.6788810130400011 1.0 0.9725905791696704 94 P28070,P25786,Q9NR28,P60900,P20618,P28482,P31749,P28074,P49327,P49721,P28072,O60313 12 Activation of the pre replicative complex 0.3437747845528801 0.4127786352890625 0.6797688058429938 1.0 0.9725905791696704 22 Q9NR33,Q14181,Q9Y619 3 Creb1 phosphorylation through nmda receptor mediated activation of ras signaling 0.4010776336254248 0.4106891370706989 0.6813004933142277 1.0 0.972891576659668 9 P07196,Q14168 2 Metabolism of lipids 0.3639188248309944 0.4065311368136211 0.6843523836367551 1.0 0.9756518604596052 181 P50897,Q16739,P37268,Q16836,Q9NPH0,Q9P035,Q15392,Q8IV08,P51648,Q15067,P07602,Q06136,Q14739,Q9BY49,P35790,O60244,P17900,Q96G23,Q9H4L5,O43772,Q15800,Q14914,Q9UMR5,Q9BWD1,Q13510,P04062,P09960,Q16850,P48449,P23786,Q9UBF8,P30536,Q8NCC3,Q13503,Q9NZ01,P42126,P10619,P49327,O95470,P42356,O15270,Q9NQZ5,P06280,Q15165,Q15125,P38435,Q9UBM7,Q5T8D3,Q01469,O95674 50 Synthesis of bile acids and bile salts 0.4535058681913983 0.4043096795370686 0.6859850084479282 1.0 0.9756518604596052 6 O14734,Q96SU4,Q9H4L5,P22059,P51659 5 Bile acid and bile salt metabolism 0.4535058681913983 0.4043096795370686 0.6859850084479282 1.0 0.9756518604596052 6 O14734,Q96SU4,Q9H4L5,P22059,P51659 5 Cd163 mediating an anti inflammatory response 0.6143467521704198 0.4042821985203777 0.6860052143856599 1.0 0.9756518604596052 3 P78536 1 Rora activates gene expression 0.4683841183809731 0.3922877062748032 0.6948456461450723 1.0 0.977426713213788 5 Q96RS0 1 Signaling by ptk6 0.3656784988191867 0.392207592156248 0.6949048349038369 1.0 0.977426713213788 14 O75525,P46108,P31749 3 Nuclear events kinase and transcription factor activation 0.3841673076908871 0.3900235268616345 0.6965191499437167 1.0 0.977426713213788 12 P30154,P28482,P30153 3 Signaling by retinoic acid 0.3822834203725256 0.3809014067184316 0.7032764086268941 1.0 0.977426713213788 12 Q01469,Q15120,O94788 3 Metalloprotease dubs 0.4254512045541471 0.3799204021238764 0.7040045021662398 1.0 0.977426713213788 7 O95630,Q92783 2 Plasma lipoprotein assembly remodeling and clearance 0.3417971824905482 0.3757926851698998 0.7070710262917208 1.0 0.977426713213788 19 Q8WTV0 1 Heparan sulfate heparin hs gag metabolism 0.4618354494226914 0.3707023220910043 0.7108592605986106 1.0 0.977426713213788 5 Q7LGA3,P54802 2 Disinhibition of snare formation 0.5837090471896598 0.3621508485228054 0.7172393072121745 1.0 0.977426713213788 2 Q12846 1 Pre notch expression and processing 0.3852337663940305 0.3565086772595411 0.721459654921093 1.0 0.977426713213788 11 P16615,Q15363,Q9HCE1,P15291 4 Ksrp khsrp binds and destabilizes mrna 0.3546689623710909 0.352143295436607 0.7247308001939488 1.0 0.977426713213788 15 P31749,Q92945,Q16539 3 Intracellular signaling by second messengers 0.3040873896802363 0.348129882455194 0.7277426433631178 1.0 0.977426713213788 88 P28070,P25786,P30154,P60900,P20618,P31749,P28074,P30153,P28482,P49721,P28072 11 Darpp 32 events 0.3849013040035177 0.346628707656377 0.7288702759489663 1.0 0.977426713213788 10 P30154 1 Mitotic spindle checkpoint 0.3046180788057569 0.34530129723085 0.7298678715312825 1.0 0.977426713213788 59 Q96EA4,P30154,Q9UJX4,O43683,Q02224,Q9H900,P30153,Q9UJX6,Q96DE5,Q8NBT2,O60566,Q16763,Q53HL2,Q9UJX3 14 Signaling by braf and raf1 fusions 0.3331690602196215 0.3443597986018984 0.7305757181664845 1.0 0.977426713213788 22 Q9NRY5,P30086,P51114 3 Golgi to er retrograde transport 0.295443788043944 0.3438733600675525 0.7309415270715209 1.0 0.977426713213788 78 Q9P2W9,P18085,Q9BVK6,Q02224,Q15363,O43731,Q13561,P84085,P24390 9 Rho gtpases activate wasps and waves 0.345287851974469 0.3430901042148942 0.7315306755141464 1.0 0.977426713213788 17 P28482,Q7L576,P62993,Q9UQB8 4 Ncam signaling for neurite out growth 0.4355546386861098 0.3416463917614057 0.7326170200797839 1.0 0.977426713213788 6 P28482,P62993,O15020 3 Homologous dna pairing and strand exchange 0.3481787523313985 0.3369802850514835 0.7361317620585797 1.0 0.977426713213788 16 Q9UQ84,P51530 2 Keratan sulfate keratin metabolism 0.4338285544865295 0.3357925053019337 0.7370273422604867 1.0 0.977426713213788 6 O43505 1 Ra biosynthesis pathway 0.4455475330926611 0.3189506819975155 0.7497639110797805 1.0 0.979704206710698 5 O94788,Q9BTZ2,Q9HBH5,Q8TC12 4 Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 0.3302264648362704 0.3113253342191773 0.7555533096648257 1.0 0.9831969131313074 20 P10619,Q86YN1,Q9Y5P6,Q06210 4 Lagging strand synthesis 0.3294452561999673 0.3065945321876553 0.7591520160178766 1.0 0.98507009369066 20 Q9Y2S7,P51530,Q14181,P41440 4 Cdc42 gtpase cycle 0.3131157378289324 0.2910500858329751 0.7710130137937825 1.0 0.9932171303034272 36 Q14739 1 Mitotic g2 g2 m phases 0.3043649645681628 0.2791743882505388 0.7801109977602405 1.0 1.0 96 P28070,P25786,P30154,P20618,P28074,P30153,Q9H6D7,P49721,P28072,O95684 10 Hdr through single strand annealing ssa 0.3396264008609039 0.2725356135227952 0.7852102115932567 1.0 1.0 15 Q9UQ84 1 Aurka activation by tpx2 0.3095011441857159 0.2713567956666722 0.7861166278300962 1.0 1.0 37 O95613,Q96CS2,Q13561,P30153,Q99996,O43805,Q9H6D7,O95684,Q68CZ6 9 Platelet activation signaling and aggregation 0.2975646391109867 0.2692939369785653 0.7877034975000781 1.0 1.0 57 Q9NTK5,P62993,O94919,P46108,P07602,P31749,P28482,Q9NUQ9,Q8N2K0,Q8NBX0 10 Met receptor recycling 0.4125200078421772 0.2662821927473836 0.790021886301806 1.0 1.0 6 P46108 1 Peroxisomal protein import 0.3225579004964829 0.2653409664227585 0.7907468085032958 1.0 1.0 20 O75874,Q15067 2 Signaling by ntrks 0.3125320593909548 0.2616645766730557 0.7935800529210155 1.0 1.0 32 P62993,P30154,P46108,P11233,P30153,P28482 6 Polymerase switching 0.3371047920440377 0.2448591003904241 0.8065655309399458 1.0 1.0 14 Q9Y2S7,Q14181,P41440 3 Vegfr2 mediated cell proliferation 0.547203848466613 0.2403511143031926 0.8100580726028346 1.0 1.0 3 O43865,P19174 2 Miscellaneous transport and binding events 0.4184717208182967 0.2397424790847037 0.8105299015426899 1.0 1.0 5 Q9UEY8,Q8N4V1,P35611,Q9UNS2 4 Dna replication initiation 0.3672996758412057 0.2346600413691091 0.8144726041316759 1.0 1.0 8 Q9NR33,Q14181 2 Vitamin b5 pantothenate metabolism 0.4739906376879724 0.2287312157660976 0.8190778312078022 1.0 1.0 4 P49327 1 Insulin receptor signalling cascade 0.3992243107639587 0.2257236720060557 0.8214163456017374 1.0 1.0 6 P28482 1 Signal attenuation 0.5387353848740674 0.2229880942398668 0.8235447726517111 1.0 1.0 3 P28482 1 Diseases of carbohydrate metabolism 0.3552738443301556 0.2209169986542768 0.8251570613909212 1.0 1.0 10 P15586,P46976,P10253,Q04446,P54802,P08236 6 Response of eif2ak1 hri to heme deficiency 0.5333734215273591 0.2124070015081766 0.8317895239874593 1.0 1.0 3 P08243,P05198 2 Activation of ppargc1a pgc 1alpha by phosphorylation 0.5315694527961335 0.2089196995646982 0.8345109254593384 1.0 1.0 3 P54646,Q16539 2 Regulation of tp53 activity 0.2914967483036604 0.2087096397802391 0.8346749144082 1.0 1.0 51 Q9UQ84,Q92804,P30154,P30153,P51530 5 Gpvi mediated activation cascade 0.4049338146811089 0.2036914380072387 0.8385946334121408 1.0 1.0 5 Q06124,P61586,P84095,P63000 4 Syndecan interactions 0.4541353383458684 0.1857248886283496 0.852660509579628 1.0 1.0 4 O14936,P12814,Q9Y296 3 Runx2 regulates bone development 0.4531207048775046 0.1836600707316832 0.8542801349289308 1.0 1.0 4 Q96PK6 1 Chylomicron assembly 0.5022542831379735 0.1805822719002687 0.8566954720731437 1.0 1.0 2 P07237 1 Notch3 intracellular domain regulates transcription 0.4971445746919153 0.1721010766805014 0.8633580663249203 1.0 1.0 2 P42224 1 Prolonged erk activation events 0.3785727641786597 0.1675228096824281 0.8669587015920333 1.0 1.0 6 P46108 1 Processing of smdt1 0.3390373379568541 0.1605230871050257 0.8724690365566643 1.0 1.0 11 P35232,Q10713,Q8IYU8,Q96TA2,Q8WWC4 5 Abc transporters in lipid homeostasis 0.4881274421400646 0.1579823217619857 0.8744707289613289 1.0 1.0 2 P40855 1 Synthesis of pips at the golgi membrane 0.3373962597267289 0.1515658068073674 0.8795294039842254 1.0 1.0 10 P42356 1 Mucopolysaccharidoses 0.4338207875191344 0.1469023321489893 0.8832091111068072 1.0 1.0 4 P54802,P08236 2 Smooth muscle contraction 0.3228240643925887 0.1437114798363976 0.8857283057070413 1.0 1.0 13 P06753,P67936,P04083,P09493 4 Notch4 activation and transmission of signal to the nucleus 0.4709948902915556 0.1340922911494326 0.8933295953634512 1.0 1.0 2 Q92542 1 Processive synthesis on the lagging strand 0.3135181938033506 0.133774330059151 0.8935810263627073 1.0 1.0 14 Q9Y2S7,P51530,Q14181 3 Regulation of ifng signaling 0.4243609022556431 0.1306496167678514 0.8960524905833418 1.0 1.0 4 P15260,P42224,P18031 3 Transport and synthesis of paps 0.4667868951006942 0.1288000462940635 0.8975158688982452 1.0 1.0 2 O43252 1 Metabolism of steroid hormones 0.3621545626200903 0.125776228622161 0.8999090591288972 1.0 1.0 6 P30536 1 Mismatch repair 0.3240714726782577 0.1236552962027071 0.9015882083760224 1.0 1.0 12 Q9UQ84 1 Chl1 interactions 0.4538623384430533 0.1139158018566799 0.9093045390404472 1.0 1.0 2 P11142 1 Molecules associated with elastic fibres 0.45386233844304 0.1139158018566656 0.9093045390404584 1.0 1.0 2 P55081 1 Elastic fibre formation 0.45386233844304 0.1139158018566656 0.9093045390404584 1.0 1.0 2 P55081 1 Biosynthesis of specialized proresolving mediators spms 0.4694777012163387 0.1115038844554504 0.9112167854603396 1.0 1.0 3 Q14914 1 Diseases of signal transduction by growth factor receptors and second messengers 0.3258405656809349 0.1082311232864196 0.9138123571458514 1.0 1.0 152 P62942,P28070,P62993,P25786,Q92614,P19388,P30154,O75832,P28074,P30153,Q9NRY5,O95684,P67936,P60900,P20618,O15164,P30086,Q92734,P49721,P28072,O15111,P51114,Q99436,P31749,Q9UBW7,Q6UN15,P78536,O95429,Q07866,P28482 30 Polymerase switching on the c strand of the telomere 0.2978277332646647 0.107378486181547 0.9144887213554213 1.0 1.0 18 P0CG13,Q9Y2S7,Q14181,P41440 4 Growth hormone receptor signaling 0.3532675002008986 0.1049522831909657 0.9164136720233688 1.0 1.0 6 P28482 1 Leishmania infection 0.2866587301136245 0.1016553957193471 0.9190302077226428 1.0 1.0 38 O14641,Q9UQB8,P46108,P09601,P28482 5 Telomere c strand lagging strand synthesis 0.2900025094549634 0.1006034718465021 0.9198652405572794 1.0 1.0 25 Q9Y2S7,P0CG13,Q14181,P41440,P51530 5 Transcriptional regulation by runx1 0.2776149003132866 0.099123704895316 0.9210400509877944 1.0 1.0 64 P28070,P25786,P20618,P28074,P49721,P28072 6 Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol 0.4530968129885744 0.0930095813536543 0.9258959494014802 1.0 1.0 3 O14734,P51659 2 Beta oxidation of pristanoyl coa 0.4530968129885744 0.0930095813536543 0.9258959494014802 1.0 1.0 3 O14734,P51659 2 Phase 0 rapid depolarisation 0.4271115118725761 0.0892811252956608 0.9288584939911716 1.0 1.0 2 Q9HD47 1 Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde 0.4271115118725544 0.089281125295644 0.928858493991185 1.0 1.0 2 P52292 1 Camk iv mediated phosphorylation of creb 0.4271115118725544 0.089281125295644 0.928858493991185 1.0 1.0 2 P52292 1 Anchoring of the basal body to the plasma membrane 0.2854264946252868 0.087665191341746 0.9301427863571332 1.0 1.0 37 O95613,Q96CS2,Q13561,P30153,Q99996,O43805,Q9H6D7,O95684,Q68CZ6 9 Pd 1 signaling 0.4241058010219601 0.0869953340114751 0.930675220966764 1.0 1.0 2 P41240 1 Sars cov infections 0.2725869799049086 0.0785240718645174 0.9374111827600052 1.0 1.0 69 P62942,Q02790,P49356 3 Hs gag degradation 0.437285335657777 0.0778205004146177 0.9379708389275084 1.0 1.0 3 P54802 1 Maturation of sars cov 1 spike protein 0.3434951943770792 0.0739096047446194 0.9410823132732156 1.0 1.0 5 P26572 1 Regulation of tp53 activity through phosphorylation 0.2851085693882128 0.070522991408397 0.943777401608493 1.0 1.0 32 Q9UQ84,Q92804,P40938,O14757,Q00535,P51530 6 Fceri mediated mapk activation 0.3171377523817493 0.0693672889835971 0.9446972657885376 1.0 1.0 8 P28482,P62993 2 Regulation of ifna signaling 0.4242333132892252 0.0671343506572075 0.9464747477007524 1.0 1.0 3 P42224,P18031 2 Rac1 gtpase cycle 0.2733187509441193 0.0642075084391478 0.9488049988637336 1.0 1.0 46 Q14739,Q9UQB8 2 Wnt mediated activation of dvl 0.4193076404345587 0.0635125752709654 0.9493583458436592 1.0 1.0 3 O14641 1 Recruitment of mitotic centrosome proteins and complexes 0.2814746020515563 0.0633204938603725 0.9495112967678568 1.0 1.0 38 O95613,Q96CS2,Q13561,P30153,Q99996,O43805,Q9H6D7,O95684,Q68CZ6 9 Diseases of mitotic cell cycle 0.3017788658539094 0.0591453582473142 0.9528363311950055 1.0 1.0 13 Q16763,Q96DE5,Q9UJX6,Q9UJX3 4 Inactivation of cdc42 and rac1 0.4046903187011407 0.0540062515672715 0.9569301834823016 1.0 1.0 3 P63000,O94813 2 Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1 0.3962717979555081 0.0493215356600153 0.960663057426736 1.0 1.0 3 P06493,P20248 2 Runx3 regulates p14 arf 0.3017733694018568 0.048191858394273 0.9615633387104288 1.0 1.0 2 P42771 1 Fructose metabolism 0.3935658448586932 0.0479305916240426 0.9617715588112664 1.0 1.0 3 Q3LXA3,Q00796 2 Uptake and function of diphtheria toxin 0.3545864661654179 0.045678467392715 0.963566526422928 1.0 1.0 4 P08238,P07900,Q16881 3 Caspase mediated cleavage of cytoskeletal proteins 0.3225474303634377 0.0429947818582939 0.9657056934828404 1.0 1.0 6 P08670 1 Activation of the ap 1 family of transcription factors 0.361329264957037 0.0351463194130999 0.9719630666580276 1.0 1.0 3 P28482 1 Asparagine n linked glycosylation 0.3006619096061679 0.0349873778278073 0.9720898057464016 1.0 1.0 121 Q86YN1,O43731,Q9Y6Y8,P24390,P18085,Q92734,Q8IUR0,Q9Y5P6,Q9BVK6,Q96PC5,Q06210,Q9BUN8,Q13561,P49257,P10619,P84085,O15027,Q15363,Q96JB2,O60476 20 Nef mediated downregulation of mhc class i complex cell surface expression 0.3382541605525661 0.0338428228086765 0.9730024878253668 1.0 1.0 4 Q9BXS5,P04439 2 N glycan antennae elongation in the medial trans golgi 0.3419823595850818 0.0302590956931429 0.9758604185307064 1.0 1.0 3 P15291 1 Adaptive immune system 0.3371054598262407 0.0268902205092564 0.9785472936015434 1.0 1.0 193 P62942,P28070,P25786,P30154,Q9UIQ6,P28074,P30153,Q9UJX6,P10321,Q8IWV7,P20618,P60900,P49721,P28072,P19474,P31749,P07858,Q9NZ08,P10619,Q03518,P55786,Q9UJX3 22 Adp signalling through p2y purinoceptor 1 0.3054720384846719 0.0249537110423882 0.9800918853356524 1.0 1.0 3 Q16539,P63218 2 Rho gtpases activate iqgaps 0.2995780590717364 0.0234357522790788 0.9813026866362664 1.0 1.0 11 Q13576,P63000,Q9BVA1,P46940,Q13509,Q9BUF5,P35222,P04350,P35221,P60953 10 Wax and plasmalogen biosynthesis 0.3175375956939642 0.0224062846903597 0.9821238671534926 1.0 1.0 4 O15228 1 Cd28 dependent vav1 pathway 0.3100831753141617 0.0223572055519595 0.982163016833178 1.0 1.0 6 P62993 1 Termination of translesion dna synthesis 0.2764519376354654 0.0184265230629903 0.9852985936880948 1.0 1.0 19 Q9NR33,P41440 2 Oncogene induced senescence 0.3038549997815821 0.0166841000592878 0.9866886317116286 1.0 1.0 7 P28482,Q9HCE1,P42771 3 Muscle contraction 0.2754170357333872 0.0123998808206789 0.9901065800685356 1.0 1.0 29 P06753,P67936,Q13177,P09493,P04083,Q99996,P16615,P08670 8 Dna strand elongation 0.2738650491856016 0.0032626989187591 0.9973967475248672 1.0 1.0 29 Q9Y2S7,P51530,Q14181,P41440 4