Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size Protein localization 0.6530490782954795 5.109470761832318 3.230624786028237e-07 0.0004554144357622 4.555180948313913e-05 75 O60830,Q13011,Q9UJS0,Q9NS69,Q99595,P56589,Q8N4H5,P21796,P05067,P09601,O75381,Q9Y512,P50402,P06576,Q13505,Q9NX63,Q5JRX3,O75431,Q3ZCQ8,O00116,Q5T8D3,Q9NR77,O96008,O95169,Q9Y3D6,P51648,Q15388,O14925,P22307,O15254,Q9BY49,Q8NBU5,P40855,O43681,O14734,Q10713,P12236,O43615,Q15067 39 Sphingolipid metabolism 0.7700438865962509 4.385366796864988 1.1579049724819155e-05 0.0161939988157403 0.001088430674133 28 O95470,P07602,O15121,P17900,P04062,Q13510,P10619,P06280,O15270,Q9NZJ7,Q16739,Q06136,P51648,P06865,O15269,P27544,P07686,Q96G23,P16278 19 Mitochondrial protein import 0.7273114534382974 4.368348057827128 1.2518986749032734e-05 0.0174969999999384 0.0011032357072585 34 O60830,Q9UJS0,Q9NS69,Q99595,Q8N4H5,P21796,Q9Y512,P06576,Q13505,Q9NX63,Q5JRX3,Q3ZCQ8,O96008,O95169,Q15388,O14925,Q10713,P12236,O43615 19 Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 0.6048116386430609 4.3312851061157005 1.4824158254267417e-05 0.0206852808266747 0.0012295331257952 67 P20674,P56385,Q9NX14,P13073,O75306,P24539,O43676,O75947,P00846,O75964,O43920,O14548,Q16134,O95168,Q9UDW1,Q86Y39,P14927,P06576,Q9Y375,O96000,P22695,P48047,O43674,P03886,P36542,O14949,O95169,Q9Y6M9,P21912,P00403,Q9P032,Q8N183,O43819,O75880 34 The citric acid tca cycle and respiratory electron transport 0.5076049165807075 4.122349534336935 3.7502757004759246e-05 0.0515060602757634 0.0029377159653728 99 P20674,P56385,Q9NX14,O75306,P13073,P24539,O43676,O75947,P00846,O75964,P21796,O43920,Q13423,O14548,O95168,Q9UDW1,Q86Y39,P14927,P06576,Q9Y375,O96000,Q9H9P8,P22695,P48047,P36542,O43674,P03886,O14949,O95169,P35613,P48735,Q9Y6M9,P21912,P00403,Q8N183,O43819,O75880 37 Cristae formation 0.7670719346704209 3.758827595553792 0.0001707114144786 0.2139411700870074 0.0104389060397956 21 Q5XKP0,P56385,Q9Y512,P36542,Q9BUR5,P24539,Q6UXV4,O75947,P00846,P06576,Q13505,O75964,Q9NX63,Q16891,O75431 15 Respiratory electron transport 0.5711801309533924 3.746859691005798 0.0001790621761124 0.2231440012759298 0.0104389060397956 57 P20674,Q9NX14,P13073,O75306,O43676,O43920,O14548,Q16134,Q9NPL8,O95168,Q9UDW1,Q86Y39,P14927,Q9Y375,O96000,P22695,O43674,P03886,O14949,O95169,Q9Y6M9,P21912,P00403,Q9P032,Q8N183,O43819,O75880 27 Ion channel transport 0.6467639232332606 3.679580523820096 0.0002336179152411 0.2806733720229076 0.0126692792496148 32 Q9Y5K8,Q9C0H2,P98194,Q93050,P51790,Q15904,P05023,Q13555,P35670,P16615,P36543,Q9HD20,Q9Y487,P20020,Q4KMQ2 15 Transport of small molecules 0.4891883569049816 3.550463120809777 0.0003845540100078 0.4186053178374871 0.0193650412182504 167 P98194,Q9C0H2,O75027,Q9Y5K8,Q5T3U5,Q8WWC4,P30519,O94905,Q9BPX6,P56589,P45880,Q6PIU2,Q99623,O00400,O15118,P21796,P08183,Q9HD20,P63010,P35232,P20020,P09601,Q9Y4W6,Q8WTV0,Q8N4V1,Q9H0U3,P28072,P08195,P16615,P35670,O75477,Q8NEW0,P30825,Q4KMQ2,P33527,Q9UJZ1,Q9Y5Y0,P49721,O95202,P61916,Q15904,P02786,Q96TA2,Q9NRK6,P63218,P55011,Q93050,P35613,Q9H2J7,Q9Y487,Q9UBV2,Q8IYU8,Q99808,P51790,Q99576,Q9Y277,Q15043,P38571,P40855,Q10713,P02794,Q8TB61,Q13555,P05023,P12236,Q9GZP9,Q9UBX3,P36543,Q70HW3 69 Glycosphingolipid metabolism 0.8117346150477578 3.5216499584844003 0.0004288700279613 0.4538362538417849 0.0208519565319127 16 P06865,P17900,P07686,Q16739,P04062,P07602,Q13510,P10619,P06280,P16278 10 Mitochondrial biogenesis 0.5936757487803395 3.4835108621379747 0.0004948830388478 0.5023995348461293 0.022509196283078 39 Q5XKP0,P56385,Q00059,Q9Y512,P36542,Q9BUR5,P24539,Q6UXV4,O75947,P00846,P06576,Q13505,O75964,Q9NX63,Q16891,Q04837,O75431,P48735 18 Mitochondrial calcium ion transport 0.7522075641627132 3.1803090583613196 0.0014711805674123 0.8745555164854205 0.0576212388903173 16 Q9BPX6,Q9UJZ1,Q8IYU8,Q9Y4W6,Q8WWC4,Q9Y277,P45880,O95202,Q10713,Q99623,P21796,P35232 12 Glycosaminoglycan metabolism 0.7246257389934463 3.10651988693064 0.0018930357500288 0.9308660967013253 0.0710184254183701 17 P15586,P06865,Q96L58,Q8NCH0,P07686,Q8TB61,Q7LGA3,P54802,P16278 9 Slc mediated transmembrane transport 0.6491871145044434 3.1032665431883584 0.0019139717488638 0.9328808636357064 0.0710184254183701 23 Q99808,Q15043,Q8TB61,O00400,P08195,P35613,P12236,Q9UBX3,Q70HW3,Q9H2J7,Q8NEW0,P30825 12 Class i peroxisomal membrane protein import 0.8103142508700258 3.024352272362279 0.0024916612465464 0.9703302285171818 0.0878310589407616 11 O75381,P56589,P40855,Q9Y3D6,P51648,Q5T8D3,Q9NR77 7 Mitochondrial translation 0.4841822121428014 2.962329503437983 0.0030532085080416 0.98658805394131 0.0989950708800835 63 Q9Y3D9,Q7Z7H8,Q9H2W6,Q9NX20,P82663,Q13084,P82673,Q96EY7,Q92665,Q9BYD6,P82664,Q96GC5,Q8IXM3,Q9Y3B7,Q9BRJ2,Q13405,P82650,P52815,Q15070,Q9BYD1,Q16540,P82933,Q96A35,Q9NQ50,Q92552,Q9Y3D3,Q9BYD2,Q8TAE8 28 Phospholipid metabolism 0.4978379792910498 2.9441345501520098 0.0032385917008543 0.9896815804776594 0.0989950708800835 53 Q6UWP7,Q8IY17,Q9UG56,Q8TBX8,Q8IV08,Q9NQZ5,P40939,Q96N66,Q92604,P20339,Q9NPH0,Q96PE3,Q9BTU6,Q9NTJ5,Q9HCL2,O15228,Q9HBU6,Q9NZC3,P55084,Q9BZF1,P35790,Q8NCC3,Q10713,Q8NF37 24 Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.674049314709529 2.8855444805007893 0.0039073724256137 0.9959949005614416 0.1059499061560661 18 O76024,O43852,P05067,Q13217,Q86UP2,Q07065,Q15293,P14625,Q02818,Q9BTY2 10 Ion transport by p type atpases 0.7591868405131906 2.839933434921399 0.0045122948493758 0.9982993307559714 0.106729818141297 12 P98194,Q13555,P35670,P16615,Q9HD20,P20020 6 Cholesterol biosynthesis 0.6328264775972391 2.817259037408527 0.0048435443877692 0.998936287820242 0.106729818141297 20 Q14534,Q15392,Q14739,O76062,Q16850,O75845,P37268,Q15125 8 Complex i biogenesis 0.5389549467310124 2.8122110563155416 0.0049202207107563 0.9990457972998458 0.106729818141297 33 O43920,Q9NX14,O95168,Q9NPL8,O75306,O43674,P03886,O43676,Q86Y39,O95169,Q9P032,Q9Y375,Q8N183,O96000,Q9Y6M9 15 Glycerophospholipid biosynthesis 0.5388145579101559 2.8109808216891605 0.0049390729821321 0.9990709498384048 0.106729818141297 33 Q9HCL2,O15228,P40939,Q6UWP7,P35790,Q96N66,Q9HBU6,Q9UG56,Q8NCC3,Q92604,Q9NPH0,Q8NF37,Q8IV08,Q9NQZ5,P55084 15 Pink1 prkn mediated mitophagy 0.7912003133785269 2.6340313063361975 0.0084377707635618 0.9999935261144682 0.1250409824226367 9 Q9NS69,Q8N4H5,O96008,P21796,Q15388 5 Mitophagy 0.705303317856751 2.62783602388072 0.0085929926361876 0.9999948084415774 0.1250409824226367 13 Q9NS69,Q8N4H5,O96008,P21796,Q15388 5 Gpcr ligand binding 0.7606526939331482 2.6156448480482246 0.0089059137854676 0.9999966735003204 0.1250409824226367 10 Q9NRV9,Q9NZJ7,P07602,P42892,Q9BYT8,P05067 6 Sphingolipid de novo biosynthesis 0.7157861440032263 2.6009521238626117 0.009296542701779 0.9999980919630348 0.1250409824226367 12 P27544,O95470,Q96G23,O15121,Q06136,P51648,O15270 7 Formation of atp by chemiosmotic coupling 0.7551197000288449 2.5868269438260425 0.0096864227458497 0.9999989046474036 0.126824297277066 10 P56134,P56385,P48047,P36542,P24539,O75947,P06576,P00846,O75964 9 Slc transporter disorders 0.5130696952781235 2.5826061712768205 0.0098057185886006 0.9999990757626004 0.1268446166048346 33 Q8TEM1,P57740,Q7Z3B4,Q9BTX1,Q8N1F7,P37198,O15504,O00400,Q9NRG9,Q8WUM0,Q6P1M0,P08195,Q8NFH4,P11166,Q99567,P35613,Q9BVL2,P12270 18 Processing of smdt1 0.7255441084167673 2.5744938692618504 0.0100386865616037 0.9999993367233556 0.1286777095623757 11 Q9BPX6,Q9UJZ1,Q8IYU8,Q9Y4W6,Q8WWC4,Q10713,Q99623,P35232 8 Heparan sulfate heparin hs gag metabolism 0.9027958117048206 2.429870556275852 0.015104216157991 0.9999999995210476 0.1658321812861092 5 Q96L58,P54802,P16278 3 Class a 1 rhodopsin like receptors 0.8325213973687894 2.4263780910730923 0.0152503730134625 0.99999999961148 0.1658321812861092 7 Q9NRV9,Q9NZJ7,P07602,P42892,P05067 5 Peptide ligand binding receptors 0.8325213973687894 2.4263780910730923 0.0152503730134625 0.99999999961148 0.1658321812861092 7 Q9NRV9,Q9NZJ7,P07602,P42892,P05067 5 Metabolism of fat soluble vitamins 0.8972287916656843 2.40627321697897 0.0161162067151545 0.9999999998875996 0.168081268607 5 Q9Y5Z9,Q8N0U8 2 Chondroitin sulfate dermatan sulfate metabolism 0.8428180494659704 2.396651216168452 0.0165456648035005 0.9999999999392676 0.168081268607 6 Q8NCH0,P06865,Q96L58,P07686 4 Rnd2 gtpase cycle 0.5938396026374467 2.3548152814909153 0.0185319152997218 0.9999999999964893 0.1765280299462543 18 Q86UP2,P02786,Q07065,P51648,Q9Y2U8,P38159 6 Peroxisomal lipid metabolism 0.6682922872957071 2.3314191296939395 0.0197312697914144 0.9999999999993738 0.1794909058444801 12 O15254,P22307,Q9BY49,P51648,Q5T8D3,Q15067 6 Depolymerisation of the nuclear lamina 0.7030281351936882 2.310564619888108 0.0208569153752107 0.999999999999876 0.1828961353082908 10 P50402,P42167,P20700,Q9Y2U8 4 Metabolism of lipids 0.4124984981027777 2.310072114998123 0.0208841619441089 0.9999999999998808 0.1828961353082908 202 Q15392,Q6UWP7,Q9NPJ6,O95470,P50897,Q9P035,Q9UG56,Q9UMR5,O76062,P07602,Q15165,Q8IY17,O15121,Q8IV08,Q9NQZ5,O43772,P37268,O75845,Q96PE3,Q14534,Q14739,P17900,Q16836,Q96N66,P50416,P04062,Q92604,P04035,Q9NPH0,P30536,Q13510,P10619,Q9BTU6,P06280,Q9NTJ5,Q5T8D3,Q15125,Q9H7Z7,O15270,Q9Y2W1,O00116,Q9HCL2,Q9NZJ7,Q16739,O95864,Q9HBU6,Q8WVX9,Q9NZC3,Q06136,P51648,P05166,Q9BZF3,P22307,P30084,Q15067,Q15800,P06865,O15269,O15254,P35790,Q9BY49,P27544,P07686,Q8NCC3,Q96G23,Q10713,Q53GQ0,Q16850,O43681,Q8NF37,Q9NVC6,P23786,P38435,P16278 74 Diseases associated with glycosaminoglycan metabolism 0.8741404263742958 2.3077400601464704 0.0210135985247823 0.9999999999999012 0.1828961353082908 5 Q8NCH0,P06865,Q96L58 3 Transport of inorganic cations anions and amino acids oligopeptides 0.7226267240368374 2.2853065949574547 0.0222948565078309 0.9999999999999843 0.1905196828851005 9 P08195,Q9UBX3,Q9H2J7,Q70HW3,P30825 5 Transferrin endocytosis and recycling 0.6589084922503948 2.2771527830562586 0.0227771036187964 0.9999999999999922 0.1923096772604972 12 Q15904,P02786,P36543,Q93050,Q9Y487 5 Keratan sulfate degradation 0.934062769939534 2.2683348067921174 0.0233088079880265 0.9999999999999964 0.1950599756534543 4 P06865,P15586,P16278 3 Rhog gtpase cycle 0.4647393058970192 2.237289837690893 0.0252674029756536 0.9999999999999998 0.2047530930785727 37 P42167,Q14739,Q6IAA8,P84095,Q8TAA9,O95202,P49257,Q86UP2,P50402,P02786,Q13190,Q86XL3,Q9Y2U8,O15173,P61604 15 Egr2 and sox10 mediated initiation of schwann cell myelination 0.8067103796272848 2.2337400838228896 0.0255001799313514 1.0 0.205458592589746 6 Q16850,Q9NR77 2 Keratan sulfate keratin metabolism 0.8525413589507443 2.2145918804736247 0.0267880898375081 1.0 0.2086903610084808 5 P15586,P06865,P16278 3 Iron uptake and transport 0.5412930639031872 2.2057216615069075 0.0274034942715963 1.0 0.2099941680595158 21 P09601,Q9Y5Y0,P30519,Q15904,P02794,P02786,P36543,Q93050,Q9Y487 9 Rnd1 gtpase cycle 0.6187125706268797 2.2001146114019328 0.0277987644664603 1.0 0.210732569342522 14 P02786,P51648,Q9Y2U8,P38159,O75976 5 Platelet calcium homeostasis 0.8477140598958107 2.193645957712526 0.0282608717625689 1.0 0.2130899956428997 5 Q13586,P16615 2 Regulation of glucokinase by glucokinase regulatory protein 0.502907555499637 2.1748355944715203 0.029642438690401 1.0 0.2188263798610759 26 P57740,Q7Z3B4,Q9BTX1,P37198,Q8N1F7,O15504,Q9NRG9,Q8NFH4,Q99567,Q9BVL2,P12270 11 Sumoylation of ubiquitinylation proteins 0.502907555499637 2.1748355944715203 0.029642438690401 1.0 0.2188263798610759 26 P57740,Q7Z3B4,Q9BTX1,P37198,Q8N1F7,O15504,Q9NRG9,Q8NFH4,Q99567,Q9BVL2,P12270 11 Metabolism of porphyrins 0.673550354607618 2.150217330661248 0.0315380279246204 1.0 0.2242155576987496 10 P09601,P30519 2 Initiation of nuclear envelope ne reformation 0.563980118925582 2.148871254140728 0.0316446070794689 1.0 0.2242155576987496 18 P42167,P20700,Q14739,P50402,Q86XL3,Q9Y2U8 6 Nuclear envelope breakdown 0.4424065556096157 2.1311573849029912 0.033076178460716 1.0 0.2280339600260538 41 P42167,P02545,P20700,P57740,Q7Z3B4,Q9BTX1,P37198,Q8N1F7,O15504,P50402,Q9NRG9,Q8NFH4,Q99567,Q9Y2U8,Q9BVL2,P12270 16 Sumoylation of rna binding proteins 0.4638397962726405 2.1302149225918985 0.0331538736208092 1.0 0.2280339600260538 33 Q8TEM1,Q8IXK0,P57740,Q7Z3B4,Q9BTX1,P61978,P37198,Q8N1F7,O15504,Q9NRG9,Q8NFH4,Q99567,P07910,Q9BVL2,P12270 15 Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.6321972257292217 2.1208405793825413 0.0339352205079317 1.0 0.2306489185554688 12 P09601,O43681,P50402,Q13190,P51648,P05067 6 Mucopolysaccharidoses 0.8977983871696716 2.120550766306798 0.033959625061583 1.0 0.2306489185554688 4 P54802,P16278 2 Viral messenger rna synthesis 0.4549379730215752 2.116274902299018 0.0343214340093822 1.0 0.2315465165226267 36 P57740,Q7Z3B4,P19388,Q9BTX1,P37198,Q8N1F7,O15504,P35269,Q9NRG9,Q8NFH4,Q99567,O15514,Q9BVL2,P12270 14 Transport of the slbp dependant mature mrna 0.464758444037478 2.096495435332097 0.0360382644233268 1.0 0.2419712039851942 31 P57740,Q7Z3B4,Q9BTX1,P37198,Q8N1F7,O15504,Q86V81,Q9NRG9,Q8NFH4,Q99567,Q9BVL2,P12270 12 Transport of mature mrnas derived from intronless transcripts 0.4473289891808661 2.0674913221840825 0.0386878810582418 1.0 0.2511801538686555 37 P57740,Q7Z3B4,Q9BTX1,Q6UN15,P37198,Q8N1F7,O15504,Q86V81,Q9NRG9,Q8NFH4,Q99567,Q9BVL2,P12270 13 Heme degradation 0.8841895583847195 2.064529465983288 0.0389675430812621 1.0 0.2511801538686555 4 P30519 1 Hcmv late events 0.4422480269218594 2.0434842343621193 0.0410045264776077 1.0 0.2553400305426475 38 P57740,Q7Z3B4,Q9BTX1,P61978,Q9H9H4,P37198,Q8N1F7,O15504,Q9H444,Q9NRG9,Q8NFH4,Q99567,Q9HD42,Q9BVL2,P12270 15 Stimuli sensing channels 0.6536520169289339 2.0403342927847277 0.0413170414632575 1.0 0.2553400305426475 10 Q9C0H2 1 Insulin receptor recycling 0.6303138966099822 2.038798736939097 0.0414701184356498 1.0 0.2553400305426475 11 Q93050,Q9Y487,Q15904,P36543 4 Synthesis of pc 0.7623711359674851 2.0295941688311703 0.0423978081279785 1.0 0.2565704268688831 6 Q9NQZ5,P35790 2 Rac2 gtpase cycle 0.4405841519038181 1.9762741683044691 0.0481237336253856 1.0 0.2736067113378783 36 Q14739,Q9Y512,P50402,P02786,Q13505,Q86XL3,Q9Y2U8,O15173 8 Endosomal vacuolar pathway 0.859352977108578 1.9615202315914977 0.0498183672860594 1.0 0.2798561668260712 4 Q9UIQ6,P10321 2 Interactions of vpr with host cellular proteins 0.445634203120085 1.9576716314066045 0.0502685560929054 1.0 0.2801528224940582 33 Q8TEM1,P05141,P57740,Q7Z3B4,Q9BTX1,P37198,Q8N1F7,O15504,Q9NRG9,Q9BVL2,P12236,Q8NFH4,Q99567,P17096,P12270 15 Ire1alpha activates chaperones 0.4895268640377963 1.945587774399136 0.0517042767429152 1.0 0.2858942361078841 24 Q9NWM8,P02545,O43731,Q9Y5M8,O95070,P43307,O14773 7 Rab geranylgeranylation 0.499927221010967 1.9320456374810615 0.0533538732177305 1.0 0.2903361128496185 22 P61026,P20337,P20340,P61020,Q969Q5,P51148,P20339,Q9H0U4,Q9NP72,P61019,P53611 11 Sumoylation of sumoylation proteins 0.466708967337779 1.930382254396696 0.0535594920486808 1.0 0.2903361128496185 27 P57740,Q7Z3B4,Q9BTX1,P37198,Q8N1F7,O15504,Q9NRG9,Q8NFH4,Q99567,Q9BVL2,P12270 11 Apoptotic cleavage of cellular proteins 0.48680547158106 1.9232641042883456 0.0544468901917307 1.0 0.2904968942895257 24 P20700,P02545,P08670,Q16625,P51572 5 Muscle contraction 0.4646902352008894 1.9126332799784245 0.0557950160871878 1.0 0.294647837763801 27 P08670,P67936,P05023,Q9NYL9,Q13555,P16615,Q13586,P20020,P28289 9 Interleukin 4 and interleukin 13 signaling 0.583409334041804 1.900138698276478 0.0574149204293175 1.0 0.2983247708085174 13 P09601,P08670 2 Reduction of cytosolic ca levels 0.8331685611695301 1.851887302581376 0.0640420076274133 1.0 0.3190785539033666 4 P16615 1 Transport of bile salts and organic acids metal ions and amine compounds 0.766977547788583 1.836612617571361 0.066267103306866 1.0 0.3278477742550214 5 Q9H2J7,P35613,Q8NEW0 3 Pre notch processing in golgi 0.762960829493093 1.818533444219915 0.0689826398507653 1.0 0.3291250058536567 5 Q9UBV2,P16615,Q15363,P20340 4 Response to elevated platelet cytosolic ca2 0.4348832510229531 1.8162871784035923 0.0693263310202383 1.0 0.3291250058536567 31 Q8NBX0,Q9NZJ7,O43852,Q6UXV4,Q9BWS9,P07602,P05067,Q08380 8 Striated muscle contraction 0.7501402539682342 1.7606424943518766 0.0782989314848681 1.0 0.3515971127186753 5 P28289,P08670,P67936 3 Transport of vitamins nucleosides and related molecules 0.6237210076109647 1.756871475701368 0.078939718584871 1.0 0.3533492165227561 9 Q8TB61,O00400,Q99808 3 Beta oxidation of lauroyl coa to decanoyl coa coa 0.8062194068528656 1.7380180021295015 0.0822076417793677 1.0 0.3618152851686229 4 Q16836,P30084,P55084 3 Ros and rns production in phagocytes 0.5991808156524567 1.7329341007558985 0.0831073823655179 1.0 0.3618152851686229 10 Q93050,Q9Y487,P36543 3 Beta oxidation of hexanoyl coa to butanoyl coa 0.740783410138251 1.7182188175075246 0.085756710469909 1.0 0.3653080415787667 5 Q16836,P40939,P30084,P55084 4 Nuclear signaling by erbb4 0.7984954155008731 1.7052019610626925 0.0881567644079073 1.0 0.3672603067488535 4 Q92542 1 Organelle biogenesis and maintenance 0.3396089452207083 1.69838971189598 0.0894342325676469 1.0 0.3672603067488535 108 P56385,Q96CS2,P24539,P00846,O75964,A6NIH7,Q9Y512,P06576,Q13505,Q9NX63,Q04837,Q00059,P36542,Q6UXV4,P41208,Q5XKP0,Q9BUR5,Q9H6D7,Q10713,Q16891,O95684,O75935 22 Vitamin d calciferol metabolism 0.7956459440733419 1.6930766944690283 0.0904408697292369 1.0 0.3672603067488535 4 P04062 1 Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux 0.7880180990186209 1.6605693421875884 0.0967999705210038 1.0 0.3831177446230393 4 Q8NB78 1 Rhod gtpase cycle 0.428566094453479 1.6535146268686007 0.0982261717568979 1.0 0.3840814063829736 28 P42167,Q14739,P20700,Q8TAA9,Q5JTV8,P49257,P50402,Q9Y2U8,O15173,Q9H0H5 10 Cs ds degradation 0.9335251798561148 1.6516391497573824 0.0986081341210187 1.0 0.3840814063829736 2 P06865 1 Nuclear pore complex npc disassembly 0.4184865751650107 1.6432404054245338 0.1003332030098616 1.0 0.3875885376545338 30 P57740,Q7Z3B4,Q9BTX1,P37198,Q8N1F7,O15504,Q9NRG9,Q8NFH4,Q99567,Q9BVL2,P12270 11 Diseases of carbohydrate metabolism 0.5825807002957415 1.6374386282716615 0.1015388525143921 1.0 0.3911742678833138 10 P15586,P54802,P16278 3 Cargo concentration in the er 0.5085218297459306 1.622861297506249 0.1046190586004365 1.0 0.3986834395313932 16 Q12907,Q5JRA6,P49755,Q96PC5,Q15363,P49257,O75396,Q13190 8 Wax and plasmalogen biosynthesis 0.7774258566081297 1.6153159275109896 0.1062422961716285 1.0 0.4026647903966416 4 O15228,O00116,Q8WVX9 3 Diseases of glycosylation 0.4583603806442519 1.5998882951735098 0.109623366398887 1.0 0.4110876239958264 22 P06865,Q96L58,Q8NCH0,P07686,P10619,Q10469,P16278 7 Alpha linolenic omega3 and linoleic omega6 acid metabolism 0.6514585027282143 1.5609274497464145 0.1185408697877334 1.0 0.4360233253226079 7 O95864,O14734,Q15067,P33121,P22307 5 Synthesis of very long chain fatty acyl coas 0.6611927398444287 1.5479315632752704 0.1216387743968896 1.0 0.4440130942165023 6 Q9NZ01,Q9P035,Q53GQ0,O95573,P33121 5 Synthesis of bile acids and bile salts 0.6474613379506795 1.5410148444004728 0.1233131731984698 1.0 0.4467427269829295 7 Q9H4L5,P22307,O14734,Q9BZF3 4 Bile acid and bile salt metabolism 0.6474613379506795 1.5410148444004728 0.1233131731984698 1.0 0.4467427269829295 7 Q9H4L5,P22307,O14734,Q9BZF3 4 Cardiac conduction 0.5261647240901004 1.5385733537020276 0.1239084878714202 1.0 0.4468311199455309 13 Q13555,Q13586,P16615,P20020 4 Rnd3 gtpase cycle 0.4871771492564123 1.5327213320272426 0.1253445308385357 1.0 0.4508566032712636 17 Q14254,Q9NYL9,Q07065,Q9Y2U8,P38159,O75976 6 Phase i functionalization of compounds 0.5246506223958189 1.5288601836643048 0.1262991087175089 1.0 0.4531342068490778 13 O43169,P07099,P16435,Q16850 4 Ion homeostasis 0.5342276488193453 1.5250873303353198 0.1272373168886504 1.0 0.4553416670380638 12 Q13555,Q13586,P16615,P20020 4 Synaptic adhesion like molecules 0.6556247788075587 1.520870756959848 0.1282922737147913 1.0 0.4557652324752532 6 O95197,P41440,O75955 3 Lysosome vesicle biogenesis 0.4855074776995881 1.5207388384622331 0.1283253881508337 1.0 0.4557652324752532 17 O00189,P05067 2 Export of viral ribonucleoproteins from nucleus 0.4129321180298339 1.508702037048667 0.1313749447423637 1.0 0.4602077519499434 28 P57740,Q7Z3B4,Q9BTX1,P37198,Q8N1F7,O15504,Q9NRG9,Q8NFH4,Q99567,Q9BVL2,P12270 11 Fgfr2 alternative splicing 0.4737623809587219 1.499728214722054 0.1336848188409338 1.0 0.4602077519499434 18 P19388,P09651,P35269,P31943,O15514,P52597,Q01085 7 Transport of mature transcript to cytoplasm 0.35729481186822 1.4994833150660642 0.1337482939905505 1.0 0.4602077519499434 66 P26368,Q8TEM1,Q8N1F7,P57740,Q7Z3B4,O95391,Q6UN15,P37198,Q8NFH4,P82979,P12270,O60508,O15504,Q86V81,Q01130,Q13242,Q9BTX1,Q9NRG9,Q07955,Q6I9Y2,Q99567,Q9BVL2 22 Pre notch expression and processing 0.5093066029849873 1.4979176147625304 0.1341546565294253 1.0 0.4602077519499434 14 Q9UBV2,Q9HCE1,P16104,P20340,Q15363,P16615,Q13573,Q04721 8 Nuclear import of rev protein 0.4030929621408754 1.4955729035139562 0.1347649886594495 1.0 0.4602077519499434 30 Q8TEM1,P06748,P57740,Q7Z3B4,Q9BTX1,P37198,Q8N1F7,O15504,Q9NRG9,Q8NFH4,Q99567,Q9BVL2,P12270 13 Maturation of sars cov 2 spike protein 0.5293586720162863 1.4946527525775617 0.1350050909935451 1.0 0.4602077519499434 12 P04843,P39656,P27824,P14314,Q9H0U3,P46977,P04844,Q10469,Q13724 9 Beta oxidation of pristanoyl coa 0.749208177368273 1.4941943486358888 0.1351248292959408 1.0 0.4602077519499434 4 O14734,O15254,P22307 3 Formyl peptide receptors bind formyl peptides and many other ligands 0.9054279013422636 1.468186678331826 0.1420535218575047 1.0 0.4653071870252241 3 P05067 1 Glycerophospholipid catabolism 0.8863309352517978 1.457076079720738 0.1450953804704453 1.0 0.4725707840375806 2 Q9NZC3 1 Beta oxidation of butanoyl coa to acetyl coa 0.74057011229485 1.4569767397174642 0.1451228010555123 1.0 0.4725707840375806 4 Q16836,P40939,P30084 3 Hs gag degradation 0.8990996797932187 1.4437895972772512 0.1487981690913575 1.0 0.4790078046091647 3 P54802 1 Beta oxidation of decanoyl coa to octanoyl coa coa 0.6720782338837009 1.4029131436264928 0.1606427409645188 1.0 0.5033472550221589 5 Q16836,P30084,P55084 3 Beta oxidation of octanoyl coa to hexanoyl coa 0.6720782338837009 1.4029131436264928 0.1606427409645188 1.0 0.5033472550221589 5 Q16836,P30084,P55084 3 Sumoylation of chromatin organization proteins 0.3832834592173896 1.400429336087172 0.1613847902941325 1.0 0.5034348546785993 36 Q8TEM1,Q8IXK0,P57740,Q7Z3B4,Q9BTX1,Q8N1F7,P37198,O15504,Q9NRG9,Q9BVL2,Q8NFH4,Q99567,P45973,P12270 14 Plasma lipoprotein clearance 0.4944158940723632 1.3990221635019249 0.1618063369033113 1.0 0.5036356181758698 14 Q8WTV0,P38571,Q6PIU2,O15118,P63010 5 Intra golgi traffic 0.4934444457068215 1.392549486639132 0.1637560671449947 1.0 0.5050769032179021 14 O00461,Q13190,O95721,O95249,Q8TBA6 5 Selective autophagy 0.3854070880724564 1.3685372665746849 0.1711439652686253 1.0 0.5200711013550898 33 Q9NS69,P08670,Q8N4H5,P21796,Q15388 5 Collagen biosynthesis and modifying enzymes 0.5130166123643576 1.3360862749629223 0.1815210755469782 1.0 0.5286013710554694 11 P13674,O75718,Q32P28,Q02809,O15460 5 Ns1 mediated effects on host pathways 0.3820644042198004 1.3351603347343772 0.1818238758595054 1.0 0.5286013710554694 33 P57740,Q7Z3B4,Q9BTX1,Q86U42,P37198,Q8N1F7,O15504,Q9NRG9,Q8NFH4,Q99567,Q9BVL2,P12270 12 Amino acid transport across the plasma membrane 0.7112006910452178 1.330097682455367 0.1834860890313925 1.0 0.5286249580171989 4 Q9H2J7,P08195,P30825 3 Synthesis of pa 0.5119345381460353 1.3294287871174246 0.1837065456939202 1.0 0.5286249580171989 11 Q9HCL2,Q9NPH0,Q6UWP7,Q8NF37 4 Ptk6 regulates proteins involved in rna processing 0.8624064478986733 1.3022763825276076 0.1928219221914522 1.0 0.5481429642942492 3 O75525,Q07666 2 Alpha oxidation of phytanate 0.8588799160377004 1.2886844706294114 0.1975078034628374 1.0 0.5569720057652017 3 P51648 1 Basigin interactions 0.6069606351436772 1.2826632942961471 0.1996100648410608 1.0 0.5595431241071486 6 P35613,P08195,P05556 3 Acyl chain remodelling of pg 0.8394244604316534 1.263808319480118 0.206298834387042 1.0 0.5673278874600542 2 Q8NF37 1 Post translational modification synthesis of gpi anchored proteins 0.5908014468480987 1.2562505183973411 0.2090251558839069 1.0 0.5675814500656791 7 Q92643,O43292,O60762,Q5H8A4,Q96S52 5 Synthesis of pe 0.8497409326424811 1.253481005735498 0.2100307073977507 1.0 0.568413238830765 3 Q9HBU6,P35790 2 Peroxisomal protein import 0.421900259052092 1.2419782145878115 0.2142446000523601 1.0 0.5753997829977672 20 Q13011,O15254,O75381,Q9BY49,O14734,Q15067,O00116,P22307 8 Rhobtb1 gtpase cycle 0.4213133957610769 1.2373055315512484 0.2159736750492351 1.0 0.576747882233753 20 P38159,P08670,Q9BT78 3 Purinergic signaling in leishmaniasis infection 0.6351856535537708 1.2317621457464765 0.2180379476009641 1.0 0.5767983229218753 5 P09601 1 Inflammasomes 0.6351856535537708 1.2317621457464765 0.2180379476009641 1.0 0.5767983229218753 5 P09601 1 The nlrp3 inflammasome 0.6351856535537708 1.2317621457464765 0.2180379476009641 1.0 0.5767983229218753 5 P09601 1 Abc transporters in lipid homeostasis 0.8427165324408619 1.2264480026759854 0.2200301313070527 1.0 0.5809784365972741 3 P56589 1 Transcriptional regulation by small rnas 0.3584093652685573 1.1999847297830513 0.2301452710241289 1.0 0.5911304146661125 39 P16104,P57740,Q7Z3B4,P19388,Q9BTX1,P37198,Q8N1F7,O15504,Q9NRG9,Q8NFH4,Q99567,O15514,Q9BVL2,P12270 14 Attachment of gpi anchor to upar 0.6806795277857847 1.1980112763154684 0.2309126270925754 1.0 0.5911304146661125 4 Q96S52,Q92643,O43292 3 Metal ion slc transporters 0.8227338129496389 1.195367389178534 0.2319435210320506 1.0 0.5911304146661125 2 Q8NEW0 1 Zinc transporters 0.8227338129496389 1.195367389178534 0.2319435210320506 1.0 0.5911304146661125 2 Q8NEW0 1 G alpha i signalling events 0.3992033871887264 1.1832521886873342 0.2367092151574557 1.0 0.5911304146661125 24 P05067,Q9NRV9,Q9NZJ7,P07602 4 Formation of fibrin clot clotting cascade 0.8181294964028761 1.176539000162718 0.2393795572932107 1.0 0.594234464407442 2 P42785 1 Intrinsic pathway of fibrin clot formation 0.8181294964028761 1.176539000162718 0.2393795572932107 1.0 0.594234464407442 2 P42785 1 Chondroitin sulfate biosynthesis 0.8155395683453225 1.1659595162129206 0.2436308139287661 1.0 0.6028766846487127 2 Q8N6G5 1 Extracellular matrix organization 0.3762415809342821 1.1641878464531927 0.2443478944236932 1.0 0.6028766846487127 28 P55081,O75718,Q08722,Q32P28,Q92542,P35613,P05067,O15460 8 Tysnd1 cleaves peroxisomal proteins 0.6176447459308172 1.150282743474172 0.2500274359344923 1.0 0.6099285201862182 5 O00116,P22307,Q15067 3 Unfolded protein response upr 0.3486889709384149 1.1373662881984816 0.2553851940760137 1.0 0.6197816241775892 41 Q9NWM8,P02545,O76024,Q96B26,O43731,Q92945,Q9Y5M8,O95070,P43307,O14773,P14625 11 Collagen formation 0.4619645244973785 1.1220151411336936 0.2618560021905098 1.0 0.6224475404106187 13 O15460,O75718,Q32P28 3 Plasma lipoprotein assembly remodeling and clearance 0.421929430478263 1.1125832878844493 0.265887441273809 1.0 0.6224475404106187 18 Q8WTV0,P38571,P61916,Q6PIU2,Q9BU23,O15118,P63010 7 Er quality control compartment erqc 0.6581404631233281 1.1006345725599709 0.2710557323592586 1.0 0.6263891143038742 4 Q9GZP9 1 Nuclear envelope ne reassembly 0.3340403651810717 1.0938771413433372 0.2740088653806101 1.0 0.6283045769520779 50 P42167,P02545,Q14739,P20700,Q9BTX1,Q7Z3B4,P37198,Q8N1F7,P50402,Q9H444,Q86XL3,Q8NFH4,Q9Y2U8 13 Acyl chain remodeling of cl 0.8059873344847401 1.085688101367978 0.2776170066740064 1.0 0.6323747647986253 3 Q6UWP7,P55084 2 Ra biosynthesis pathway 0.6536135905557314 1.08112150953186 0.2796430665716749 1.0 0.6359624578484865 4 Q9HBH5,Q8NBN7,O94788 3 Linoleic acid la metabolism 0.7905035971223007 1.0642067912066488 0.2872350312032485 1.0 0.6428593555501277 2 O95864 1 Miscellaneous transport and binding events 0.552079968755993 1.0602289200124857 0.2890404672611297 1.0 0.6458748951476909 7 Q8N4V1 1 Regulation of lipid metabolism by pparalpha 0.382656165288344 1.040526005445747 0.2980955885252192 1.0 0.6604847456319797 24 Q9NPJ6,P50416,Q9NVC6,P04035,P23786,Q15067,P37268 7 Hyaluronan uptake and degradation 0.5900452700472361 1.022386485301544 0.3065980144160281 1.0 0.670237519886201 5 P06865 1 Hyaluronan metabolism 0.5900452700472361 1.022386485301544 0.3065980144160281 1.0 0.670237519886201 5 P06865 1 Sialic acid metabolism 0.5835090191704588 0.9922142467709216 0.3210930241841201 1.0 0.6891037505321299 5 P16278 1 Ldl clearance 0.4476801641836095 0.9777034654716114 0.3282210073057459 1.0 0.7011994246986389 12 P38571,P63010,O15118,Q6PIU2 4 Cytochrome p450 arranged by substrate type 0.7731854945292516 0.9613845990329506 0.3363588250620846 1.0 0.7095033830573161 3 Q16850 1 Neurotransmitter release cycle 0.5405553113306552 0.9560702562765604 0.3390367407347483 1.0 0.7109181621441222 6 O94925,O14795,P51649,O75915 4 Diseases associated with o glycosylation of proteins 0.7623021582733795 0.9510828486289326 0.3415623206302496 1.0 0.7124302841548119 2 O43505 1 Notch2 activation and transmission of signal to the nucleus 0.7623021582733793 0.9510828486289312 0.3415623206302502 1.0 0.7124302841548119 2 Q92542 1 Mitotic prophase 0.3175569839573515 0.9386244943469868 0.3479235722147127 1.0 0.7214297600334485 61 P02545,Q8N1F7,Q9H0U4,Q01105,P57740,Q7Z3B4,P37198,P50402,Q08379,Q8NFH4,P61019,P12270,P20700,O15504,Q9Y2U8,P42167,P16104,Q9BTX1,Q9NRG9,Q99567,Q9BVL2 21 Miro gtpase cycle 0.5715105909462106 0.937008468895314 0.3487542016310994 1.0 0.7220901972097653 5 O95140,Q8IXI1,Q8IWA4 3 Trans golgi network vesicle budding 0.3291375152092424 0.9239284214091475 0.3555235843455391 1.0 0.7225946573491348 41 Q99523,P15586,O00189,Q14789,P11717,O60749,P02794,P02786,P55327,Q9Y5X3,Q12846,P05067,O75976 13 Mrna splicing 0.3080093630695257 0.8944872485663411 0.3710612493157827 1.0 0.734826350470862 151 P26368,Q16629,P08579,Q13435,Q8N684,P42285,P33240,Q15637,Q13247,P55795,P52756,Q96I25,P67809,P62310,Q9P013,Q8IWZ8,Q9BXP5,Q9BUJ2,Q7RTV0,O95391,Q6UN15,O60828,Q15427,Q9UHX1,P35637,Q9UBB9,O75400,Q13573,P22626,Q9P2I0,P09234,P09012,O75934,P19388,Q12996,Q8WWY3,O60508,P17844,O43290,O43390,P09651,Q12874,Q9Y2W2,Q01130,Q99459,P35269,Q86V81,Q13242,O95400,O15514,P62995,P61978,Q86U42,P51991,Q15717,O75937,P31943,Q07955,Q13151,O75494,P52272,P07910,P38159,Q92733,P52597 65 Signaling by insulin receptor 0.3988159855163868 0.8903552923020471 0.373275140329554 1.0 0.7371399830037412 17 Q93050,Q9Y487,Q15904,P36543 4 Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol 0.7489925158318884 0.8710562010660118 0.3837234673091372 1.0 0.7504162120747343 3 O14734,P22307 2 Nrif signals cell death from the nucleus 0.7415827338129477 0.8693629126287663 0.3846486618409437 1.0 0.7511836747863305 2 Q92542 1 Metabolism of folate and pterines 0.4887409648740347 0.8603643806373739 0.389588214071102 1.0 0.754343933445826 8 Q9H2D1,P41440,P13995 3 Metabolism of steroids 0.3126200495329155 0.8432969048573878 0.3990624134228242 1.0 0.7594425259559135 53 Q14534,Q15392,Q14739,O76062,P04062,Q53GQ0,Q16850,P38435,O75845,P30536,Q9BZF3,P37268,Q15125 13 Synthesis secretion and deacylation of ghrelin 0.7409326424870375 0.8412958428614875 0.4001822189634074 1.0 0.7594425259559135 3 P67812,Q15005 2 Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip 0.7409326424870375 0.8412958428614875 0.4001822189634074 1.0 0.7594425259559135 3 P67812,Q15005 2 Interactions of rev with host cellular proteins 0.3327720808212502 0.8403270245123303 0.4007250531101689 1.0 0.7594425259559135 33 Q8TEM1,P06748,P57740,Q7Z3B4,Q9BTX1,P37198,Q8N1F7,O15504,Q9NRG9,Q8NFH4,Q99567,Q9BVL2,P12270 13 Cobalamin cbl vitamin b12 transport and metabolism 0.5957888446034816 0.834734358094015 0.4038672921009061 1.0 0.7613006442009059 4 P33527,Q96EY8 2 Diseases associated with n glycosylation of proteins 0.506526194314522 0.8310632183287526 0.4059379170226005 1.0 0.7622231082626783 7 Q9BT22,Q96AA3,Q10469 3 Autophagy 0.3103738410998925 0.8152971834848503 0.414902220581778 1.0 0.7655327362128745 52 Q9NS69,P08670,Q8N4H5,O96008,Q7Z3C6,P21796,Q15388,Q8IWA4 8 Ripk1 mediated regulated necrosis 0.4210277316166945 0.8092979196911363 0.4183438025553567 1.0 0.7680530750039752 12 O00560,P41440,O75955 3 Integrin cell surface interactions 0.5886868856155281 0.805037038093798 0.4207983067926575 1.0 0.7685564929762267 4 P35613,Q08722 2 Processing of capped intron containing pre mrna 0.316668164706899 0.7963081635166119 0.4258529418130452 1.0 0.771790035933668 194 P26368,P08579,Q96FV9,Q15637,P67809,Q7Z3B4,Q7RTV0,O60828,Q9UHX1,Q9UBB9,Q8NFH4,Q9P2I0,Q12996,O60508,O43290,Q01130,Q99459,Q86U42,O75937,Q13151,O75494,P38159,Q8N1F7,P33240,Q96I25,P57740,P35637,O75400,Q12874,Q9Y2W2,P35269,O15514,Q9BTX1,Q6I9Y2,P07910,Q92733,Q8N684,P55795,P62310,Q9P013,Q8IWZ8,O95391,Q15007,P22626,P09234,P09012,O75934,P12270,Q8WWY3,P17844,P09651,O15504,P62995,P61978,Q9NRG9,P31943,Q07955,P52272,Q99567,P52597,Q9BVL2,Q8TEM1,Q16629,Q13435,P42285,P52756,Q9BXP5,Q9BUJ2,Q6UN15,P37198,Q15427,P82979,Q13573,P19388,O43390,Q86V81,Q13242,O95400,P51991,Q15717,Q8WUM0,Q13247 82 O linked glycosylation 0.7271157167530122 0.7907369923347646 0.4290974845446769 1.0 0.7736923954066425 3 Q10472,O43505 2 O linked glycosylation of mucins 0.7271157167530122 0.7907369923347646 0.4290974845446769 1.0 0.7736923954066425 3 Q10472,O43505 2 Meiotic synapsis 0.3846824770755614 0.7879962709458513 0.430698887122189 1.0 0.7744004859653723 17 Q9UH99,P20700 2 Rhoa gtpase cycle 0.3080307120830091 0.7872460252686633 0.4311378592076718 1.0 0.7744004859653723 50 Q14254,P30519,O75955,Q86UP2,Q9P0I2,Q9H0H5,Q14739,P51572,Q96CS3,O15173,Q5T8D3,P41440,Q96HY6,Q15904,P02786,P42167,P49257,Q8NBN3,Q13190,Q07021 20 Platelet adhesion to exposed collagen 0.717985611510789 0.7781820396679099 0.4364617033638187 1.0 0.7819707773100183 2 P07948 1 Maturation of sars cov 1 spike protein 0.5790474402815935 0.765012853242039 0.4442638909390504 1.0 0.792926691422862 4 Q13724,P27824 2 Signaling by retinoic acid 0.405852319279617 0.7570994432950503 0.4489902875723972 1.0 0.7963223968265158 13 Q15118,Q9HBH5,P50416,Q8NBN7,P11177,Q15120,O94788 7 Retrograde transport at the trans golgi network 0.3732824169130681 0.7488079177483346 0.4539729868064079 1.0 0.8030117463113089 18 P20340,Q7Z6M1,O60499,Q5VZE5,Q9UP83,Q13439 6 Defective intrinsic pathway for apoptosis 0.3895138603756299 0.7478457062138663 0.4545532294913901 1.0 0.8030117463113089 15 P20700,P02545,P05067,Q08379 4 Rhobtb gtpase cycle 0.3236884253142792 0.7227311148105847 0.4698450955952609 1.0 0.8197065576123278 30 Q96DH6,Q9BT78,P08670,Q8N684,P62995,Q9NYL9,P07910,P38159 8 Trafficking and processing of endosomal tlr 0.7030215827338107 0.7216350721380724 0.4705188703172576 1.0 0.8197065576123278 2 P14625 1 Incretin synthesis secretion and inactivation 0.5238618990683093 0.7215449566254608 0.4705742911127717 1.0 0.8197065576123278 5 P67812,Q15005 2 Synthesis secretion and inactivation of glucagon like peptide 1 glp 1 0.5238618990683093 0.7215449566254608 0.4705742911127717 1.0 0.8197065576123278 5 P67812,Q15005 2 Hiv transcription initiation 0.3801868505088532 0.7173885418743197 0.4731343876368683 1.0 0.8203740015973028 16 Q92804,P19388,P35269 3 Release of apoptotic factors from the mitochondria 0.7061024755325176 0.7151363472765064 0.4745247963154979 1.0 0.8203740015973028 3 O60443,Q9NR28 2 Rna polymerase ii transcription termination 0.3014058807429487 0.7147401314310758 0.4747696349669497 1.0 0.8203740015973028 47 P26368,O95391,Q6UN15,O60508,Q86U42,Q86V81,Q01130,Q07955,Q13242,P82979,Q6I9Y2 11 Sumoylation of dna damage response and repair proteins 0.3010073935190766 0.7101592575564603 0.4776053828770197 1.0 0.8220777076087781 47 Q8TEM1,Q8IXK0,P57740,Q7Z3B4,Q9BTX1,Q96SB8,P37198,Q8N1F7,O15504,Q9NRG9,Q8NFH4,P41208,Q99567,Q9BVL2,P12270 15 Noncanonical activation of notch3 0.6987050359712207 0.705533780138156 0.4804781176155668 1.0 0.8231763618930124 2 Q92542 1 Sulfur amino acid metabolism 0.4233226319436224 0.7013537477031561 0.483082279060264 1.0 0.8256315314848148 10 Q9UBX3 1 Unwinding of dna 0.3988659583924988 0.671373561511854 0.5019825831165432 1.0 0.8426136216599118 12 P33991 1 Proton coupled monocarboxylate transport 0.6883453237410047 0.6673105347178901 0.504573798668265 1.0 0.8444578456106288 2 P35613 1 Apoptotic execution phase 0.3129532161455939 0.6639466755392673 0.5067244409747627 1.0 0.8446148496004998 35 P20700,P02545,P08670,Q16625,P51572 5 Glutamate neurotransmitter release cycle 0.6894070236039068 0.6563819455033473 0.5115784040701912 1.0 0.8486182938105524 3 O14795,O75915 2 Beta oxidation of very long chain fatty acids 0.4771168345474428 0.6515109162545751 0.5147167326970457 1.0 0.8508338047224815 6 O14734,Q15067 2 Cohesin loading onto chromatin 0.409576002307474 0.6226780268647087 0.5334961249797279 1.0 0.8657500933605928 10 Q9NTI5,O60216,Q9UQE7,Q9Y6X3,Q7Z5K2,Q8WVM7,Q8N3U4,Q14683,Q29RF7 9 Ubiquinol biosynthesis 0.6796200345423054 0.6225622562504032 0.5335722206598263 1.0 0.8657500933605928 3 Q9Y2Z9,Q86YH6 2 Ptk6 expression 0.6733812949640263 0.6132387305388499 0.5397184990003505 1.0 0.8707129102866067 2 P04150 1 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0.4945920403691447 0.5940927343597343 0.5524500901678908 1.0 0.8793658073960333 5 Q99808 1 Binding and uptake of ligands by scavenger receptors 0.4573715342430948 0.5911057729845118 0.5544495520324211 1.0 0.8793658073960333 7 P02794,Q8WTV0 2 Peptide hormone metabolism 0.3489390198184767 0.5715378565321414 0.5676351064464817 1.0 0.8926663128918721 18 Q8NEW0,P67812 2 Dopamine neurotransmitter release cycle 0.6607194244604289 0.5686521801356754 0.5695922060311704 1.0 0.8933537380466634 2 O14795 1 Free fatty acids regulate insulin secretion 0.6604316546762563 0.5676522027458233 0.5702711528701592 1.0 0.8934248061632494 2 O95573 1 Regulation of mecp2 expression and activity 0.387066461801559 0.5658064380482635 0.5715253694663647 1.0 0.8937385663725886 11 Q13555,Q14739 2 Prevention of phagosomal lysosomal fusion 0.5273190489430939 0.557775009646069 0.576998029507489 1.0 0.897962513917426 4 P20339 1 Pi metabolism 0.3310652076343763 0.5403514056130906 0.5889547134658157 1.0 0.908562522961488 21 Q8IY17,Q10713,P20339,Q9NZC3,Q96PE3,Q9BTU6,Q9NTJ5 7 Mitotic telophase cytokinesis 0.3695150115473403 0.528570022586878 0.5971037602749045 1.0 0.9142483475930546 13 Q9NTI5,O60216,Q9UQE7,Q9Y6X3,Q6KC79,O95235,Q02241,Q7Z5K2,Q8WVM7,Q8N3U4,Q14683,Q29RF7 12 Pre notch processing in the endoplasmic reticulum 0.6483453237410043 0.5262232982420376 0.5987330681741754 1.0 0.9156330001362118 2 Q04721 1 Transcriptional regulation by mecp2 0.3507908508354204 0.5167312414303281 0.6053437841589306 1.0 0.9170792932905698 16 Q13555,Q14739,P18031 3 Immunoregulatory interactions between a lymphoid and a non lymphoid cell 0.4759221047617582 0.5157520758661908 0.6060275781138798 1.0 0.9170792932905698 5 P10321 1 Shc1 events in erbb2 signaling 0.6448920863309322 0.514598920514467 0.606833319602909 1.0 0.9170792932905698 2 Q05655 1 Role of lat2 ntal lab on calcium mobilization 0.6448920863309322 0.514598920514467 0.606833319602909 1.0 0.9170792932905698 2 P07948 1 Mitochondrial fatty acid beta oxidation of unsaturated fatty acids 0.5156444351635417 0.5133161856245863 0.607730163773414 1.0 0.9174513179020491 4 P55084 1 Establishment of sister chromatid cohesion 0.4208705678870104 0.5107914064523573 0.6094971272240959 1.0 0.918152723702965 8 O60216,Q9UQE7,Q7Z5K2,Q8WVM7,Q8N3U4,Q14683,Q29RF7 7 Gene and protein expression by jak stat signaling after interleukin 12 stimulation 0.3195963230050146 0.5068478604411967 0.6122615719126192 1.0 0.9183923134838956 24 O14979,P20700,Q13126,P78417,P22626 5 Interleukin 12 signaling 0.3127373200339016 0.5022600449532288 0.615484610677248 1.0 0.920289820842969 26 O14979,P20700,Q13126,P78417,P22626 5 Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.3758593732639054 0.5009284387777482 0.6164214870589504 1.0 0.9207142974079662 11 Q96DE5,Q9UJX6,Q9UJX4,P30260,Q9UJX3 5 Signaling by flt3 fusion proteins 0.4708939608506812 0.4951344429708087 0.62050522247675 1.0 0.9233734107686582 5 P62993,Q14789 2 Antigen presentation folding assembly and peptide loading of class i mhc 0.3503211793726885 0.4874342964175852 0.6259505939056957 1.0 0.9261944980938726 15 P51572,Q9NZ08,P10321 3 Platelet homeostasis 0.367626091595241 0.4832941632813263 0.6288868837580599 1.0 0.926319394996898 12 P20020,Q13586,P16615 3 Fcgr activation 0.6336690647481983 0.4775131225630611 0.6329967787044264 1.0 0.926319394996898 2 P07948 1 Adenylate cyclase inhibitory pathway 0.6333812949640258 0.4765766178335517 0.6336636368093951 1.0 0.926319394996898 2 P08754 1 Regulation of pyruvate dehydrogenase pdh complex 0.4123895571618586 0.469405738371257 0.6387796474447462 1.0 0.9268291315120964 8 Q15118,P11177,Q15120 3 Gaba receptor activation 0.4644223411609376 0.4689319766550995 0.6391182589399709 1.0 0.9268291315120964 5 Q9Y639,P63218 2 Biological oxidations 0.2823190919097831 0.4671524041650061 0.6403908435515842 1.0 0.9268291315120964 44 O43169,P21964,Q9NX62,P07099,Q9NUJ1,Q8TB61,Q16850,P78417,P16435,Q99735 10 Calnexin calreticulin cycle 0.3914915488754071 0.4611820625833338 0.6446679897622694 1.0 0.9268291315120964 9 Q9UBV2,P30101,Q9GZP9,P27824 4 Citric acid cycle tca cycle 0.3329764076988998 0.4591036439353728 0.6461597400524317 1.0 0.9277853701363836 18 Q13423,P21912 2 Metabolism of steroid hormones 0.4339375582719846 0.4568264659580082 0.6477957812634159 1.0 0.929188251863089 6 P30536 1 Disinhibition of snare formation 0.6214738054116177 0.4336132503440134 0.6645693111142563 1.0 0.9351221526601872 3 Q12846,P05771 2 Interferon gamma signaling 0.3529780084238487 0.429105920553595 0.6678461438494165 1.0 0.9351221526601872 13 Q13555,P10321,P18031 3 Signaling by erbb4 0.403410165870563 0.4264127891047521 0.6698070839307071 1.0 0.9351221526601872 8 Q92542 1 Processing of intronless pre mrnas 0.3382453007475129 0.4109555019319981 0.6811051637541461 1.0 0.9410511096107812 15 Q9P2I0,Q8N684,Q6UN15,Q86U42,P33240 5 Signaling by pdgfr in disease 0.4218343001300303 0.4053062493861274 0.685252413392998 1.0 0.9454069499844688 6 Q6UN15 1 Plasma lipoprotein remodeling 0.6089208633093492 0.3998133960805863 0.689293963211266 1.0 0.9488500695931305 2 Q9BU23 1 Chylomicron assembly 0.6089208633093491 0.3998133960805854 0.6892939632112667 1.0 0.9488500695931305 2 Q9Y6B6 1 Reactions specific to the complex n glycan synthesis pathway 0.6085346429272249 0.3949499432269239 0.6928798305171424 1.0 0.9488500695931305 3 Q10469 1 N glycan antennae elongation in the medial trans golgi 0.6085346429272249 0.3949499432269239 0.6928798305171424 1.0 0.9488500695931305 3 Q10469 1 Traf6 mediated nf kb activation 0.4167361535835224 0.3841027755926188 0.7009022743656459 1.0 0.951203069441513 6 P05067 1 Dna damage recognition in gg ner 0.3216359852723612 0.3818479278468631 0.702574166264422 1.0 0.951203069441513 18 P41208 1 Regulated necrosis 0.3077189337629893 0.3780161765431264 0.7054185769334222 1.0 0.951203069441513 22 O00560,Q9H444,P41440,O75955 4 Translation of sars cov 2 structural proteins 0.3160911695099126 0.3774335640552134 0.7058514276380334 1.0 0.951203069441513 19 P04843,Q9H0U3,P46977,Q10472,P04844,Q10469 6 Tp53 regulates metabolic genes 0.2819942052786045 0.3699753441634374 0.711400861463648 1.0 0.951203069441513 36 P20674,O14548,Q9HCE1,P13073,O43819,O75880 6 Antigen activates b cell receptor bcr leading to generation of second messengers 0.4699412714698533 0.3508547707591871 0.7256973047219175 1.0 0.9607823470966232 4 Q13586 1 Amyloid fiber formation 0.4066252231011618 0.3430078471828329 0.7315925567024837 1.0 0.9658665776690094 6 P05067 1 Fgfr2 mutant receptor activation 0.3416567356752293 0.3362274239634773 0.7366993741692474 1.0 0.968168144032728 12 P19388,P35269 2 Signaling by fgfr2 iiia tm 0.3416567356752293 0.3362274239634773 0.7366993741692474 1.0 0.968168144032728 12 P19388,P35269 2 Rac3 gtpase cycle 0.2790794771770769 0.3354573820747651 0.7372800882267228 1.0 0.968168144032728 35 Q14739,P50402,P02786,Q9Y2U8,O15173 5 Methylation 0.3836475775398452 0.3352853829561387 0.7374098189595837 1.0 0.968168144032728 8 P78417 1 Interleukin 12 family signaling 0.2817252801004739 0.331541948465259 0.7402351606092996 1.0 0.968168144032728 29 O14979,P20700,Q13126,P78417,P22626 5 Gamma carboxylation hypusine formation and arylsulfatase activation 0.3402583540238078 0.3286298344758962 0.7424354948114555 1.0 0.968168144032728 12 O60725,P38435 2 Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways 0.3355052645155917 0.3286224796565357 0.7424410546377482 1.0 0.968168144032728 13 P09601 1 Akt phosphorylates targets in the nucleus 0.5821582733812916 0.3229082457677814 0.7467647313496291 1.0 0.968168144032728 2 P31751 1 Runx2 regulates genes involved in cell migration 0.5821582733812916 0.3229082457677814 0.7467647313496291 1.0 0.968168144032728 2 P31751 1 Downregulation of erbb2 erbb3 signaling 0.5821582733812916 0.3229082457677814 0.7467647313496291 1.0 0.968168144032728 2 P31751 1 Signaling by fgfr 0.2918209810888595 0.308369292085224 0.7578013455525068 1.0 0.9690575692553264 25 P19388,P09651,P35269,P31943,O15514,P52597,Q01085 7 Signaling by fgfr2 0.2918209810888595 0.308369292085224 0.7578013455525068 1.0 0.9690575692553264 25 P19388,P09651,P35269,P31943,O15514,P52597,Q01085 7 Late endosomal microautophagy 0.3342909207856653 0.2966374061960756 0.7667433495401699 1.0 0.9690575692553264 12 Q9H444,P08670 2 Golgi associated vesicle biogenesis 0.276063089455889 0.2924519286647457 0.769941109343173 1.0 0.9690575692553264 32 Q99523,Q14789,P11717,O60749,P02794,P02786,P55327,Q9Y5X3,O75976 9 Nr1h2 and nr1h3 mediated signaling 0.3930687365876372 0.2900942570767338 0.7717441291774048 1.0 0.9690575692553264 6 Q8NB78 1 Postmitotic nuclear pore complex npc reformation 0.2955254214863738 0.2894988324309687 0.7721996732445149 1.0 0.9690575692553264 22 Q9BTX1,Q7Z3B4,P37198,Q8N1F7,Q8NFH4 5 Lysine catabolism 0.3891584335660785 0.2894269772287454 0.7722546531230989 1.0 0.9690575692553264 7 P09622,Q9BQT8,Q92947 3 Interferon alpha beta signaling 0.3432827995251148 0.2709166373887056 0.786455148605453 1.0 0.9787718844244788 10 P10321,P18031 2 G alpha z signalling events 0.3847751514299263 0.2590766266473749 0.7955761184920003 1.0 0.9872598253784391 6 P08754,Q05655,P05771,P63218 4 Defects in cobalamin b12 metabolism 0.5523796295957368 0.2454387772071302 0.8061167071463831 1.0 0.9909253650751674 3 Q96EY8 1 Signaling by notch2 0.552290071094848 0.2452267011512393 0.8062809029325162 1.0 0.9909253650751674 3 Q92542 1 Signaling by gpcr 0.2580328750102539 0.2366360271931541 0.8129391682055918 1.0 0.9932792263170576 47 Q9NRV9,Q9NZJ7,P07602,P42892,P05067 5 Platelet activation signaling and aggregation 0.259677745980905 0.2309977207299706 0.8173165727449572 1.0 0.995809404078734 57 Q8NBX0,Q9Y6I9,Q9NZJ7,O43852,Q6UXV4,Q9BWS9,P07602,P05067,Q08380 9 Cargo recognition for clathrin mediated endocytosis 0.2653743758417768 0.2014625254358747 0.8403369290268099 1.0 1.0 32 Q9BT78,Q99627,P02786,Q14108,Q96D71,P63010 6 Synthesis of pips at the golgi membrane 0.3335684996806768 0.1871824515283051 0.8515175833168351 1.0 1.0 9 Q9BTU6,Q10713 2 Rho gtpase cycle 0.2683352298939717 0.1856925808382424 0.8526858467666965 1.0 1.0 165 Q14254,P67936,P30519,Q9P0I2,Q86UP2,O75955,Q08378,P61604,Q9H0H5,Q14739,Q9Y512,Q5JTV8,P50402,Q13505,P51572,O15173,O75976,Q5T8D3,Q6IAA8,P20700,P84095,P08670,Q9BT78,P41440,Q96HY6,O95202,Q15904,P02786,Q9NYL9,Q86XL3,P51648,Q9Y2U8,P42167,Q96DH6,P62995,P49257,Q8NBN3,Q13190,Q07065,P80723,Q07021,P07910,P38159,Q9UH62 44 N glycan trimming in the er and calnexin calreticulin cycle 0.2967510804731234 0.1845105096300446 0.8536129832075103 1.0 1.0 16 P54727,Q9UBV2,P27824,Q9GZP9,P30101,Q13724 6 Cytoprotection by hmox1 0.2506334973537487 0.1695370166548494 0.8653742586757747 1.0 1.0 70 P20674,P09601,P49721,P30519,Q8TCT9,P13073,O75880 7 Apoptotic factor mediated response 0.3181890719568548 0.157256249095801 0.8750428993374302 1.0 1.0 10 O60443,Q07021,Q9NR28 3 Integrin signaling 0.3527308851850028 0.1548073833756001 0.8769731702952837 1.0 1.0 7 P18031 1 Platelet aggregation plug formation 0.3527308851850028 0.1548073833756001 0.8769731702952837 1.0 1.0 7 P18031 1 Regulation of tp53 activity through association with co factors 0.5020149683361949 0.141011877405926 0.8878605592893454 1.0 1.0 3 P31749,P31751 2 Regulation of innate immune responses to cytosolic dna 0.4982728842832307 0.1344774806321925 0.8930250171836769 1.0 1.0 3 P19474,Q9UJV9 2 Signaling by fgfr2 in disease 0.2936096891715808 0.1330889175612123 0.8941230596812115 1.0 1.0 14 P19388,P35269 2 Regulation of gene expression in beta cells 0.4942429476108057 0.1276332284722115 0.8984392336623805 1.0 1.0 3 P31749,P31751 2 Growth hormone receptor signaling 0.3439468872621772 0.1238579560229647 0.9014277427734324 1.0 1.0 6 P18031 1 Inla mediated entry of listeria monocytogenes into host cells 0.4866187050359668 0.1210833537404867 0.9036250139497076 1.0 1.0 2 O60716 1 Scavenging by class a receptors 0.489927435026988 0.1205256183957762 0.9040667870179172 1.0 1.0 3 P02794 1 Foxo mediated transcription of oxidative stress metabolic and neuronal genes 0.3399596658023647 0.1123795397433192 0.910522477472312 1.0 1.0 6 P04150,P04179,Q13547,Q9NTG7,Q96ST3 5 Abortive elongation of hiv 1 transcript in the absence of tat 0.2802892438993707 0.1115309894086159 0.9111952928953096 1.0 1.0 17 Q8IXH7,P19388,P35269 3 Transcriptional activation of mitochondrial biogenesis 0.2795780101533509 0.1078598071787158 0.9141069002842668 1.0 1.0 17 P06576,Q00059,Q04837 3 Signaling by fgfr in disease 0.264472745342197 0.1017351500623084 0.9189669011675216 1.0 1.0 24 O95684,P35269,P19388,O94905 4 Sars cov 2 infection 0.2551229424550922 0.096264626387503 0.923310404627685 1.0 1.0 28 P04843,P27824,Q9H444,Q9H0U3,P46977,Q10472,P04844,Q10469 8 Ca2 pathway 0.3495861963068754 0.0948991333621714 0.9243949448908766 1.0 1.0 5 Q9HCE1 1 Mitochondrial fatty acid beta oxidation of saturated fatty acids 0.3336469295763151 0.0944589237556027 0.9247446105968165 1.0 1.0 7 Q16836,P40939,P30084,P55084 4 Downregulation of erbb4 signaling 0.4656115107913624 0.0929665938562941 0.9259301004937306 1.0 1.0 2 P46934 1 Signaling by ntrk3 trkc 0.370572991649868 0.0893841762107909 0.9287765986853358 1.0 1.0 4 P19174,P62993,Q07812 3 Trna processing in the nucleus 0.2479928560637775 0.0847662954237989 0.9324471894226328 1.0 1.0 39 Q8TEM1,P57740,Q7Z3B4,Q9BTX1,Q52LJ0,Q8N1F7,P37198,O15504,P33240,Q9NRG9,Q9BVC5,Q8NFH4,Q99567,Q9BVL2,P12270 15 Trna modification in the mitochondrion 0.3651022171033725 0.079473286702689 0.9366561785154844 1.0 1.0 4 Q7L0Y3,Q9Y606,O15091 3 Hur elavl1 binds and stabilizes mrna 0.3277914477315455 0.0794121403080894 0.9367048125690064 1.0 1.0 6 Q01105,Q05655 2 Protein protein interactions at synapses 0.2781095653353957 0.0793543197163835 0.9367508015934394 1.0 1.0 15 O95197,P41440,O75955 3 Ncam signaling for neurite out growth 0.3269951022760085 0.0773647451445972 0.9383333859953152 1.0 1.0 6 Q13813,P27361,P62993,P28482,Q01082 5 Pyruvate metabolism and citric acid tca cycle 0.249063225396984 0.0762111979782705 0.9392510739025428 1.0 1.0 34 Q9H9P8,Q13423,P21912,P21796 4 Synthesis of pips at the plasma membrane 0.2886667067216784 0.0703103451791609 0.9439466486245384 1.0 1.0 11 Q9BTU6,P20339,Q96PE3 3 Dissolution of fibrin clot 0.4342446043165419 0.0610933943661226 0.951284829858032 1.0 1.0 2 P07355 1 Signaling by braf and raf1 fusions 0.2571745974314339 0.0570830201059979 0.9544790623587796 1.0 1.0 24 Q13555,P02545,Q9NRY5 3 Signaling by nodal 0.423021582733808 0.0523527491242328 0.9582476231864888 1.0 1.0 2 P27361 1 Signaling by activin 0.423021582733808 0.0523527491242328 0.9582476231864888 1.0 1.0 2 P27361 1 Smooth muscle contraction 0.2831047286006038 0.0493616294295503 0.9606311061448882 1.0 1.0 11 Q05682,P06753,P08133,P67936 4 Mecp2 regulates transcription of neuronal ligands 0.4277489925158213 0.0428103808164079 0.9658526888824984 1.0 1.0 3 Q96ST3,P51608 2 Signal attenuation 0.4231433506044778 0.0387798024021675 0.9690659480678824 1.0 1.0 3 P62993,P27361 2 Signaling by fgfr4 in disease 0.3758273381294917 0.0280258907608593 0.9776415014133168 1.0 1.0 2 P62993 1 Rhot1 gtpase cycle 0.3735251798561104 0.0272629712036769 0.9782499905818064 1.0 1.0 2 Q8IXI2 1 Repression of wnt target genes 0.3276706017851964 0.0246573362174915 0.9803282854904314 1.0 1.0 4 Q13363,P56545,Q13547 3 Gaba b receptor activation 0.3276194824199684 0.0245974416134646 0.9803760599802438 1.0 1.0 4 P63218 1 Adp signalling through p2y purinoceptor 12 0.3276194824199684 0.0245974416134646 0.9803760599802438 1.0 1.0 4 P63218 1 Golgi cisternae pericentriolar stack reorganization 0.2738407497374364 0.0234580246353486 0.9812849207511938 1.0 1.0 12 Q9H0U4,Q08379 2 Chl1 interactions 0.3545323741007146 0.0221136581015466 0.9823572915511568 1.0 1.0 2 P05556 1 Sumoylation of dna replication proteins 0.2413978971384992 0.0208960532696776 0.9833285749724192 1.0 1.0 35 P57740,Q7Z3B4,Q9BTX1,P37198,Q8N1F7,O15504,Q9NRG9,Q8NFH4,Q99567,Q9BVL2,P12270 11 Recognition and association of dna glycosylase with site containing an affected purine 0.3236395047509332 0.0200532348101878 0.9840009058498742 1.0 1.0 4 P16104,Q9NYB0,Q15554 3 Regulation of tlr by endogenous ligand 0.3246043165467574 0.0172568016013671 0.9862317477946518 1.0 1.0 2 O60443 1 Met interacts with tns proteins 0.3208633093525129 0.0168587220060642 0.9865493231502452 1.0 1.0 2 P05556 1 Notch2 intracellular domain regulates transcription 0.3168345323740956 0.0164708430417623 0.9868587628143844 1.0 1.0 2 Q04721 1 G alpha s signalling events 0.3053014547256172 0.0118228467675651 0.990566952858026 1.0 1.0 5 P08754,P04899,P63218 3 Regulation of kit signaling 0.3158376002960034 0.0118134365320919 0.9905744606153066 1.0 1.0 4 P07948,P62993 2 Runx1 interacts with co factors whose precise effect on runx1 targets is not known 0.2575209418514663 0.0041009190633376 0.9967279491655694 1.0 1.0 17 Q969G3,Q8IXK0,Q96GM5,Q8TAQ2,Q92922 5