diff --git a/interpro_active_site/advanced/idx2term.json b/interpro_active_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_active_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_active_site/basic/idx2term.json b/interpro_active_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_active_site/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_active_site/consensus.joblib b/interpro_active_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..f423c9ca03cba00107fcd8599bb9ac7b754bd1f0 --- /dev/null +++ b/interpro_active_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:16e7d2b8662dbd1ade8648bfd26d03cf712e1ad9e7c691ed44f5894ad133618a +size 75042 diff --git a/interpro_active_site/df_merge.tsv b/interpro_active_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_active_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_active_site/metrics.json b/interpro_active_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..64091ac6a62b9b5501664c1f6bcdf012c9b590de --- /dev/null +++ b/interpro_active_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3120, + "annotations_size": 54, + "title": "Average number of proteins per term", + "value": 2.574074074074074 +} \ No newline at end of file diff --git a/interpro_active_site/paths.json b/interpro_active_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..8e82a54cf612c719c3026eef3a1d67c4eca2a42f --- /dev/null +++ b/interpro_active_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C390/C390_val_log2fc"} \ No newline at end of file diff --git a/interpro_active_site/result.tsv b/interpro_active_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..dea0d47dc12b39fad8969963741966dfb2cc0611 --- /dev/null +++ b/interpro_active_site/result.tsv @@ -0,0 +1,4 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Histidine acid phosphatase active site [IPR033379] 0.9900577293136624 1.7568362546023455 0.0789457235473234 0.988213033222178 0.2131534535777732 2 Q9NPH0 1 +Serine carboxypeptidase, serine active site [IPR018202] 0.9711260827718956 1.7225723835136637 0.0849658826709092 0.991727943210552 0.2184836982966236 3 Q9HB40,Q9H3G5 2 +Tyrosine-protein kinase, active site [IPR008266] 0.4287006022453715 0.0332753281212976 0.973455028168854 1.0 0.99182210417204 3 Q15375 1 diff --git a/interpro_active_site/selections.json b/interpro_active_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..df0ca6de48bc2c92c14ccc15d9c4528c55c70842 --- /dev/null +++ b/interpro_active_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthase, F0 complex, subunit A, active site [IPR023011]", "ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenosine/AMP deaminase active site [IPR006650]", "Adenylosuccinate synthase, active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Coenzyme A transferase active site [IPR004164]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]", "Uracil-DNA glycosylase, active site [IPR018085]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADA", "ADSS", "AKT2", "APEH", "ATP5A1", "ATP5B", "ATP6", "ATP6V1A", "ATP6V1B2", "AURKA", "BLMH", "CAMK2D", "CAMK2G", "CAPN1", "CAPN2", "CDK1", "CDK12", "CDK16", "CDK2", "CDK4", "CDK5", "CDK7", "CDK9", "CHEK2", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK1E", "CSNK2A2", "CTSA", "CTSC", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "EPHA7", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLUD1", "GSK3A", "GSK3B", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "LDHA", "LDHB", "LONP1", "MAP2K1", "MAP2K2", "MAP3K7", "MAPK1", "MAPK3", "MARK2", "MDH1", "MDH2", "NEK9", "NME1", "NME2", "OXCT1", "PAK2", "PBK", "PGAM1", "PKM", "PKMYT1", "PKN2", "PLK1", "PREP", "PRKAA2", "PRKACA", "PRKCD", "PRPF4B", "PTK7", "PTPN1", "PTPN11", "PTPRF", "RIPK1", "RNASET2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SLK", "SND1", "SRPK1", "STK38", "SUCLG1", "TALDO1", "TIGAR", "TOP1", "TPI1", "TPP2", "TRIO", "TTK", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "UMPS", "UNG", "VRK1"], "leading_proteins": ["ACP6", "CPVL", "EPHA7", "SCPEP1"]} \ No newline at end of file diff --git a/interpro_binding_site/advanced/idx2term.json b/interpro_binding_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..e1e55d708cde8a0c4c8bfcfc03da5a1ee13fbe7c --- /dev/null +++ b/interpro_binding_site/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Beta tubulin, autoregulation binding site [IPR013838]", "1": "EF-Hand 1, calcium-binding site [IPR018247]"} \ No newline at end of file diff --git a/interpro_binding_site/advanced/plot_0.png b/interpro_binding_site/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..c1ed5b8e62b0bfb9b9c76b3973a1749f104411b4 --- /dev/null +++ b/interpro_binding_site/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:6ca7bc411c7cef54f1ce697070371e2b4b466d216e52a916c720eb16c3a57ac1 +size 165966 diff --git a/interpro_binding_site/advanced/plot_1.png b/interpro_binding_site/advanced/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..b490bbfff0435bc9cd64f11183d5f248e1b4ce28 --- /dev/null +++ b/interpro_binding_site/advanced/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:4d4115bcb15d85251410c7c272b3d93a871a0f6c7389708018c07f7e8aeb46d6 +size 184102 diff --git a/interpro_binding_site/basic/idx2term.json b/interpro_binding_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..e1e55d708cde8a0c4c8bfcfc03da5a1ee13fbe7c --- /dev/null +++ b/interpro_binding_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Beta tubulin, autoregulation binding site [IPR013838]", "1": "EF-Hand 1, calcium-binding site [IPR018247]"} \ No newline at end of file diff --git a/interpro_binding_site/basic/plot_0.png b/interpro_binding_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..5052ec502e0e21e4436e1a9e4fda037922537e7e --- /dev/null +++ b/interpro_binding_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:aabd96c8e83527725f8ed3a854a9de41265759526118cdee3c9ed3fe2976fce7 +size 141641 diff --git a/interpro_binding_site/basic/plot_1.png b/interpro_binding_site/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..09b302282f21ece8de7eae89b3f18d54e6f8dc5c --- /dev/null +++ b/interpro_binding_site/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:82514f7db5b7699a4fb51c61eb17538d72df45330c039b5d8ad1bc5f223a2e67 +size 138119 diff --git a/interpro_binding_site/consensus.joblib b/interpro_binding_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..ea57c831e6d7dbe8d0b4ad9e0aaf60b5df29a6e8 --- /dev/null +++ b/interpro_binding_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:211f67e9849b4767c14e62d2f5eba1e824f24dc2be33c2994ff4b4b6d4f4239b +size 73158 diff --git a/interpro_binding_site/df_merge.tsv b/interpro_binding_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..3910969096a6b1a55c9d1162385d626b769be56f --- /dev/null +++ b/interpro_binding_site/df_merge.tsv @@ -0,0 +1,3 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Beta tubulin, autoregulation binding site [IPR013838] 5 6 2.217143950031643 0.0266132563012388 3.5533980582524274 5.54126213592233 0.5823511994709325 0.3808337519133083 1.5578062452886454 0.9632803779920796 1.1906256051626651 0.3058955364405814 1.0025096548661049e-05 1.0 1.0 0.1973959389561772 2.8311070051942505e-05 +EF-Hand 1, calcium-binding site [IPR018247] 16 35 2.0624093515123887 0.039168779739376 10.019417475728156 36.70631067961165 0.9532938980945532 0.3894555773109194 3.76037227687173 3.057484685571999 1.1082350706804749 0.3408841825650379 0.0036456478209502 0.0531691841805127 0.0402942577421927 0.2974580094294764 0.0047064147832106 diff --git a/interpro_binding_site/metrics.json b/interpro_binding_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..62627a3d22a61100589cee93f1c0245085f429c7 --- /dev/null +++ b/interpro_binding_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3120, + "annotations_size": 31, + "title": "Average number of proteins per term", + "value": 4.645161290322581 +} \ No newline at end of file diff --git a/interpro_binding_site/paths.json b/interpro_binding_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..54c54f7bcbbb7036d6122d24c9305a7874f51623 --- /dev/null +++ b/interpro_binding_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C390/C390_val_log2fc"} \ No newline at end of file diff --git a/interpro_binding_site/result.tsv b/interpro_binding_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..fa96fd982432d6ec461c0643a0c3575c3bac065a --- /dev/null +++ b/interpro_binding_site/result.tsv @@ -0,0 +1,5 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Beta tubulin, autoregulation binding site [IPR013838] 0.8188824662813031 2.217143950031643 0.0266132563012388 0.5666405718212666 0.1031263681673007 6 Q13885,Q9BVA1,P07437,Q9BUF5,P68371 5 +EF-Hand 1, calcium-binding site [IPR018247] 0.482097893902239 2.0624093515123887 0.039168779739376 0.7102254164194555 0.1317848851353061 35 Q6NUK1,P80303,Q9UBV8,Q15293,Q9NWM8,Q02818,O75746,Q9BRK5,Q9H4M9,Q9H223,P41208,Q96D71,O43852,Q14257,O95202,Q9BPX6 16 +Peptidase M16, zinc-binding site [IPR001431] 0.7181612291797281 1.6287438640597718 0.1033672527912181 0.9660333680332208 0.2670320697106469 5 Q10713 1 +Hexokinase, binding site [IPR019807] 0.7174470814625031 0.6573595275132368 0.5109497688022031 0.9999999997656 0.6570080745391734 2 P52789 1 diff --git a/interpro_binding_site/selections.json b/interpro_binding_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..cfe0fa37e6f61974aa64d19f6d402756db8f63cc --- /dev/null +++ b/interpro_binding_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Coenzyme A transferase binding site [IPR004163]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]", "Ureohydrolase, manganese-binding site [IPR020855]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT2", "APEX1", "ARG2", "AURKA", "BPNT1", "CALU", "CAMK2D", "CAMK2G", "CAPN1", "CAPN2", "CDK1", "CDK12", "CDK16", "CDK2", "CDK4", "CDK5", "CDK7", "CDK9", "CETN2", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK1E", "CSNK2A2", "CYB5B", "DBT", "DLAT", "DLST", "DST", "EHD1", "EHD4", "EIF2AK2", "EPHA7", "EPS15", "EPS15L1", "FKBP10", "FKBP14", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "GSK3B", "HK1", "HK2", "HMBS", "IDE", "ILKAP", "IQGAP1", "IQGAP2", "IQGAP3", "LETM1", "MACF1", "MAP2K1", "MAP2K2", "MAP3K7", "MAPK1", "MAPK14", "MAPK3", "MARK2", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH14", "MYH9", "MYO1B", "MYO1C", "MYO1D", "NFS1", "NRDC", "NUCB1", "NUCB2", "OXCT1", "OXSR1", "PA2G4", "PAK2", "PAK4", "PC", "PCCA", "PDCD6", "PDHX", "PEF1", "PGD", "PKMYT1", "PKN2", "PLCG1", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1F", "PPM1G", "PRKAA2", "PRKACA", "PRKCD", "PRKCSH", "PSAT1", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "STK26", "STK38", "STK4", "TKT", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["CALU", "CETN2", "EHD1", "EHD4", "FKBP14", "HK2", "LETM1", "MICU1", "NUCB1", "NUCB2", "PEF1", "PMPCA", "RCN1", "RCN2", "REPS1", "SDF4", "SLC25A12", "SLC25A24", "TUBB", "TUBB2A", "TUBB2B", "TUBB4B", "TUBB6"]} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/idx2term.json b/interpro_conserved_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..50f5f6bf60392487b8c5de4caa387f8f05e828fe --- /dev/null +++ b/interpro_conserved_site/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Intermediate filament protein, conserved site [IPR018039]", "1": "Syntaxin/epimorphin, conserved site [IPR006012]", "2": "Tubulin, conserved site [IPR017975]"} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/plot_0.png b/interpro_conserved_site/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..53d48a9d469615a5bd7fdfcf4114c3f39f771ede --- /dev/null +++ b/interpro_conserved_site/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:9e3fac147208ba32115305bff69ddbeb721b21778bb0c852915c61316eca4636 +size 182790 diff --git a/interpro_conserved_site/advanced/plot_1.png b/interpro_conserved_site/advanced/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..a11db2dc0708cf006da6fcd21616d0cea817b816 --- /dev/null +++ b/interpro_conserved_site/advanced/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:8849a7af81c3940ba96a40bc4180767a11ae870292617fde3b1dbb76798d359b +size 182121 diff --git a/interpro_conserved_site/advanced/plot_2.png b/interpro_conserved_site/advanced/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..893c18557de0a58408779fed09570177d3a7e94a --- /dev/null +++ b/interpro_conserved_site/advanced/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:fef9f3573b6f89cd30d86f91af71ea4c31b5f5a60b2617590aa4976ee790afdc +size 178919 diff --git a/interpro_conserved_site/basic/idx2term.json b/interpro_conserved_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..7d4c93b48b94f1735325759cf4befb083d2b7756 --- /dev/null +++ b/interpro_conserved_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Intermediate filament protein, conserved site [IPR018039]", "1": "Syntaxin/epimorphin, conserved site [IPR006012]", "2": "Tubulin, conserved site [IPR017975]", "3": "14-3-3 protein, conserved site [IPR023409]"} \ No newline at end of file diff --git a/interpro_conserved_site/basic/plot_0.png 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sha256:5357168823c234223683a7c8cb7cd876c5afa6b1f4a3757e220e96d57426d31a +size 91068 diff --git a/interpro_conserved_site/df_merge.tsv b/interpro_conserved_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..a1a44ba75da7dfae0bb9affb1bd0ac936b535e16 --- /dev/null +++ b/interpro_conserved_site/df_merge.tsv @@ -0,0 +1,4 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Intermediate filament protein, conserved site [IPR018039] 7 8 2.539423265749998 0.0111035399638976 4.060679611650485 7.546116504854369 0.7869831563787604 0.2926647109331939 1.9153715257926656 0.8924219614624045 1.3691577499316503 0.3120813432784052 0.1557086547662877 1.0 1.0 0.3559534457378639 0.0097510399506001 +Syntaxin/epimorphin, conserved site [IPR006012] 5 7 2.1265644208842 0.033456291328977 2.592233009708738 5.847087378640777 0.9961908981999794 0.2839139128702306 1.4759357288864456 1.4239341993278547 1.138258151200134 0.2914162845337057 0.0127797815125809 0.0595353304203936 0.0066572828402184 0.0033170374819039 0.0027630263410089 +Tubulin, conserved site [IPR017975] 5 7 2.0895229346523223 0.0366606756361753 3.6140776699029127 5.883495145631068 0.537603280896448 0.3771225437200781 1.6631634011190108 1.117390952728082 1.2199662970774952 0.3090115161057067 0.000508394757649 1.0 1.0 0.3559534457378639 0.0013369974246366 diff --git a/interpro_conserved_site/metrics.json b/interpro_conserved_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..142cadf773562fd6f5635f5a414f48737127daa2 --- /dev/null +++ b/interpro_conserved_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3120, + "annotations_size": 274, + "title": "Average number of proteins per term", + "value": 2.6605839416058394 +} \ No newline at end of file diff --git a/interpro_conserved_site/paths.json b/interpro_conserved_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..f243d1338238c3e7438c0a86172aa37d2330360b --- /dev/null +++ b/interpro_conserved_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C390/C390_val_log2fc"} \ No newline at end of file diff --git a/interpro_conserved_site/result.tsv b/interpro_conserved_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..4c2c82d7a6087207ab594bfcf28f1e0b3537145b --- /dev/null +++ b/interpro_conserved_site/result.tsv @@ -0,0 +1,32 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Intermediate filament protein, conserved site [IPR018039] 0.8206940874036005 2.539423265749998 0.0111035399638976 0.9530835335744045 0.1847406372560039 8 P20700,P48681,Q03252,Q16352,P07197,P08670,P07196 7 +Syntaxin/epimorphin, conserved site [IPR006012] 0.772314206387499 2.1265644208842 0.033456291328977 0.999910733082885 0.200900502486241 7 O15400,Q9P2W9,O60499,O43752,Q13190 5 +Tubulin, conserved site [IPR017975] 0.7644139892546106 2.0895229346523223 0.0366606756361753 0.9999640643778894 0.200900502486241 7 Q13885,Q9BVA1,P07437,Q9BUF5,P68371 5 +Tetraspanin, conserved site [IPR018503] 0.985246953175112 1.7369545789164331 0.0823951884768312 0.9999999999414324 0.3178829091749875 2 O60637 1 +Haem oxygenase conserved site [IPR018207] 0.9637588197562574 1.6480032080369134 0.0993520128786429 0.9999999999996468 0.3501861484121711 2 P30519 1 +Lysosome-associated membrane glycoprotein, conserved site [IPR018134] 0.9111610006414366 1.4297608656439509 0.1527856645457981 1.0 0.4228613341974614 2 P13473 1 +Glycoside hydrolase, family 29, conserved site [IPR018526] 0.9047466324567028 1.4031554358688756 0.1605704932530476 1.0 0.4328190112903487 2 P04066 1 +Guanylate kinase, conserved site [IPR020590] 0.6470316262682072 1.3003329514863775 0.1934868790114459 1.0 0.4776162599021277 5 Q14168,Q00013,Q9NZW5 3 +Heavy-metal-associated, conserved site [IPR017969] 0.8726747915330345 1.2704320630502226 0.2039307681959257 1.0 0.4857485196951406 2 P35670 1 +ABC transporter-like, conserved site [IPR017871] 0.5569203774798983 1.0666529256909665 0.2861285915877549 1.0 0.5850689111570512 7 O75027 1 +Short-chain dehydrogenase/reductase, conserved site [IPR020904] 0.4897841585870228 1.059660799449052 0.2892989427197867 1.0 0.5853595965441283 11 Q9Y394,Q8NBN7,Q53GQ0 3 +Proteasome beta-type subunit, conserved site [IPR016050] 0.5194304377633512 1.0073281489658956 0.3137771069729922 1.0 0.6097512575219849 8 P28074 1 +Polyprenyl synthetase, conserved site [IPR033749] 0.7896087235407556 0.9329898898351252 0.3508251884184408 1.0 0.6359649547981845 2 O95749 1 +DnaJ domain, conserved site [IPR018253] 0.4681837359336919 0.9301290194261876 0.3523042872590358 1.0 0.6359649547981845 11 Q9Y2G8,Q96KC8 2 +Immunoglobulin/major histocompatibility complex, conserved site [IPR003006] 0.7639512508017945 0.8323456310676945 0.4052138810796455 1.0 0.6918050525257065 2 P04439 1 +Mini-chromosome maintenance, conserved site [IPR018525] 0.5255185569075023 0.8265316911399233 0.4085025484606701 1.0 0.6918050525257065 6 Q14566 1 +Aldehyde dehydrogenase, cysteine active site [IPR016160] 0.5024325576522944 0.7904179727767047 0.4292837093694726 1.0 0.6918050525257065 7 P51648 1 +Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364] 0.7148813341885802 0.648053493256476 0.5169503523137564 1.0 0.7578416431898952 2 Q8N4Q0 1 +Thioredoxin, conserved site [IPR017937] 0.4266551344638164 0.6203691127130389 0.5350148027782946 1.0 0.7578416431898952 10 Q9H3N1,Q9H1E5,O43396,P07237 4 +Ubiquitin interacting motif [IPR003903] 0.4962402201446313 0.6082227466882916 0.5430397501234105 1.0 0.7578416431898952 5 Q8IZ07 1 +14-3-3 protein, conserved site [IPR023409] 0.4457289659601848 0.4561499034339971 0.6482821868260846 1.0 0.8252432377230629 6 P62258,Q04917,P31946,P61981,P63104 5 +Aldehyde dehydrogenase, glutamic acid active site [IPR029510] 0.4305827642097777 0.4399371006240634 0.6599826640677797 1.0 0.8252432377230629 7 P51648 1 +Acyl-CoA-binding protein, ACBP, conserved site [IPR022408] 0.6289288005131448 0.3661449829219831 0.7142568930227418 1.0 0.8435620202078933 2 Q9H3P7 1 +HMG box A DNA-binding domain, conserved site [IPR017967] 0.5723452037215345 0.2804682819180716 0.7791182566736246 1.0 0.8969680770108114 3 O15347,P09429 2 +Mitogen-activated protein (MAP) kinase, conserved site [IPR003527] 0.5540583894770699 0.2351465793245906 0.8140949669977326 1.0 0.9179507035283077 3 Q16539,P27361 2 +Cyclic nucleotide-binding, conserved site [IPR018488] 0.5311096856959532 0.1436931392035492 0.8857427890965717 1.0 0.9517393106371004 2 P13861 1 +Dynamin, GTPase region, conserved site [IPR019762] 0.4906991661321282 0.0882429420638139 0.9296835875838516 1.0 0.9654606633747382 2 P50570 1 +AMP-binding, conserved site [IPR020845] 0.3428571428571468 0.0650037313980638 0.9481710293144564 1.0 0.9766874512487258 5 O95573,Q6P1M0,P33121,O60488 4 +Histidine triad, conserved site [IPR019808] 0.4544579858883832 0.0551313724907688 0.9560338025112088 1.0 0.9774375443584744 2 Q9BX68 1 +Actin, conserved site [IPR004001] 0.438241899262121 0.042053832785386 0.9664557836859506 1.0 0.9807736471479648 3 P61163,P42025 2 +Heat shock protein Hsp90, conserved site [IPR019805] 0.408084696823869 0.0174706566868775 0.986061141844707 1.0 0.9969769478429878 3 P07900,P14625 2 diff --git a/interpro_conserved_site/selections.json b/interpro_conserved_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..5767c5ceb349b52b2e04a5fc1296b7beae322719 --- /dev/null +++ b/interpro_conserved_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Bax inhibitor 1, conserved site [IPR006213]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAMSAP, spectrin and Ca2+/calmodulin-binding region [IPR031372]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific, conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family A, conserved site [IPR019760]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "Dihydroorotate dehydrogenase, conserved site [IPR001295]", "DnaJ domain, conserved site [IPR018253]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Ependymin, conserved site [IPR018224]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Ferritin, conserved site [IPR014034]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glutathione peroxidase conserved site [IPR029760]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Heavy-metal-associated, conserved site [IPR017969]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site [IPR023076]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Integrin alpha chain, C-terminal cytoplasmic region, conserved site [IPR018184]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Lysophospholipase patatin, conserved site [IPR001423]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RIO kinase, conserved site [IPR018935]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P, conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "Ribosome-binding factor A, conserved site [IPR020053]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor TFIIB, conserved site [IPR023486]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class V, conserved site [IPR001426]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPA, conserved site [IPR022658]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]", "Zinc finger, XPA-type, conserved site [IPR022652]", "tRNA-dihydrouridine synthase, conserved site [IPR018517]"], "available_proteins": ["AAAS", "AAMP", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK4", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANKRD13A", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "APEX1", "ARHGEF7", "ARIH2", "ATAD1", "ATAD2", "ATP5C1", "ATP5O", "ATP7A", "ATP7B", "BAG6", "BAZ1A", "BAZ1B", "BCS1L", "BOP1", "BPNT1", "BRCA1", "BRD1", "BRD2", "BRD3", "BRD4", "BUD31", "CAD", "CALR", "CAMSAP3", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBR1", "CBX1", "CBX3", "CBX5", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDH2", "CDK5RAP1", "CDKAL1", "CETN2", "CHAF1B", "CHD1", "CHD1L", "CHD4", "CLGN", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "CORO1C", "CPOX", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYP51A1", "DCAF13", "DCAF7", "DCPS", "DCXR", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHFR", "DHODH", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX38", "DHX40", "DHX8", "DHX9", "DIDO1", "DIS3", "DLG1", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC16", "DNAJC2", "DNAJC21", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DRG1", "DRG2", "DSG2", "DST", "DTYMK", "DUS2", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EHHADH", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "EIF4E2", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPRS", "EPS15", "ETFA", "ETFB", "EXO1", "EZR", "FARP2", "FBL", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXK1", "FOXK2", "FTL", "FUCA1", "FUCA2", "GAA", "GALK1", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GGPS1", "GLA", "GLB1", "GLO1", "GMPPA", "GNPDA1", "GNS", "GOLGA2", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "GTF2B", "GTF3C2", "GUF1", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCR", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "ILVBL", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INTS12", "IQGAP1", "IQGAP2", "IQGAP3", "ITGAV", "IVD", "KDM2A", "KDM5A", "KDSR", "KIF11", "KIF14", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK14", "MAPK3", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "ME2", "MGST2", "MID1", "MIF", "MPI", "MPP1", "MPP2", "MPP6", "MPST", "MRC2", "MRPL13", "MRPL3", "MRPS11", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NEFL", "NEFM", "NES", "NF1", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD1", "NSD2", "NSF", "NUBP2", "NUDT1", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PEX1", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF3", "PHGDH", "PHIP", "PI4KA", "PIK3C2A", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PNP", "PNPLA6", "POLA1", "POLD1", "POLG", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR2E", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS1", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "QDPR", "RACK1", "RAE1", "RANBP2", "RARS", "RASA1", "RBFA", "RCL1", "RDH13", "RDX", "RIDA", "RIOK2", "RNF2", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSF1", "RTCA", "S100A10", "S100A11", "SART1", "SBDS", "SCAF11", "SCAP", "SCD", "SCP2", "SDHB", "SEC61A1", "SERPINB1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A4", "SLC2A1", "SLC2A8", "SLIT2", "SMARCA4", "SMS", "SMU1", "SNRNP40", "SNU13", "SORD", "SPATA5", "SPATA5L1", "SPTBN1", "SPTBN2", "SRCAP", "SRM", "STAM", "STMN1", "STRN", "STX10", "STX12", "STX18", "STX4", "STX5", "STX6", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SYNE1", "SYNE2", "TBL3", "TCP1", "TFB1M", "THOC6", "TK1", "TLN1", "TLN2", "TMBIM6", "TMX1", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM13", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TRMT11", "TSFM", "TSPAN3", "TSPAN6", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBG1", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UBA5", "UHRF1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP28", "USP33", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4A", "VPS4B", "WARS", "WARS2", "WDR1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR5", "WDR61", "WDR7", "WDR77", "XPA", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2"], "leading_proteins": ["ABCB7", "ACBD3", "ACSL1", "ACSL3", "ACSL4", "ACTR1A", "ACTR1B", "ALDH3A2", "ANKRD13A", "ATP7B", "DHRS7", "DNAJC1", "DNAJC16", "DNM2", "FUCA1", "GGPS1", "HINT2", "HLA-A", "HMGB1", "HMGB3", "HMOX2", "HSD17B12", "HSP90AA1", "HSP90B1", "INA", "LAMP2", "LMNB1", "LMNB2", "MAPK14", 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"Target SNARE coiled-coil homology domain [IPR000727]", "9": "SH3 domain [IPR001452]", "10": "PDZ domain [IPR001478]", "11": "Sterile alpha motif domain [IPR001660]", "12": "14-3-3 domain [IPR023410]", "13": "Protein kinase, C-terminal [IPR017892]", "14": "B-box-type zinc finger [IPR000315]"} \ No newline at end of file diff --git a/interpro_domain/basic/plot_0.png b/interpro_domain/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..e19c3b62fa6472df293d58c51b87e23e420b1fd5 --- /dev/null +++ b/interpro_domain/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:47d5bd3bba8d46399f36b7faa0f2d72ff23e33ef832ba9c1017f544a78f95ef4 +size 144858 diff --git a/interpro_domain/basic/plot_1.png b/interpro_domain/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..b88dc1670c7c0aecc5c80c5cfa0af449cea3ff04 --- /dev/null +++ b/interpro_domain/basic/plot_1.png @@ -0,0 +1,3 @@ +version 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overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +P-type ATPase, haloacid dehalogenase domain [IPR044492] 7 8 2.7360476652840746 0.0062182018272194 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 1.387816695443604e-05 1.0 1.0 0.0152248647419399 5.100313122590283e-06 +Intermediate filament, rod domain [IPR039008] 7 8 2.539423265749998 0.0111035399638976 4.060679611650485 7.546116504854369 0.7869831563787604 0.2926647109331939 1.9153715257926656 0.8924219614624045 1.3691577499316503 0.3120813432784052 0.2129060007756208 1.0 1.0 0.4160065505344545 0.0200033311952484 +EF-hand domain [IPR002048] 19 42 2.3664690972745497 0.0179586734580241 12.385922330097088 43.512135922330096 1.0171858714399242 0.3947118087831401 4.608360476919044 4.087317384177653 1.201458704248258 0.3652478399429377 0.0018132074343934 0.0803264485172424 0.0714976342213511 0.2217728174508684 0.0032143698496569 +Cation-transporting P-type ATPase, C-terminal [IPR006068] 4 5 2.268224098030487 0.0233155513984633 2.2985436893203883 4.150485436893204 0.5310155053290574 0.3897464493012307 1.1928988171245156 0.7984662222288074 1.1360507856968378 0.3059467081218019 0.0004059252135544 1.0 1.0 0.0229613270793894 5.436360967141595e-05 +Cation-transporting P-type ATPase, N-terminal [IPR004014] 4 5 2.268224098030487 0.0233155513984633 2.2985436893203883 4.150485436893204 0.5310155053290574 0.3897464493012307 1.1928988171245156 0.7984662222288074 1.1360507856968378 0.3059467081218019 0.0004059252135544 1.0 1.0 0.0229613270793894 5.436360967141595e-05 +LEM domain [IPR003887] 4 6 2.1599450062333303 0.030776927092343 2.237864077669903 5.759708737864078 0.8787481060627674 0.3228260833428172 1.2758866328838632 0.4653299410110203 1.033781091163317 0.2887768895441466 3.287944493314721e-05 1.0 1.0 0.0081566962170519 1.5236816634742336e-06 +Immunoglobulin-like domain [IPR007110] 8 13 2.116601952687457 0.0342936442633112 4.480582524271845 12.427184466019416 0.4075261998509777 0.4433674298264088 2.6479725987944898 3.173316973839475 1.1756568118942026 0.3233613924696422 0.6526078420709629 1.0 1.0 0.7615373729224523 0.8052822553147774 +GOLD domain [IPR009038] 5 7 2.1020620297116426 0.0355478424592528 2.8762135922330097 6.247572815533981 0.4192390492462461 0.3068843884052658 1.4199402534298398 0.930533270242389 1.3963570929114475 0.294203492723015 0.0127797815125809 1.0 1.0 0.0379575415698398 0.0027630263410089 +Tubulin/FtsZ, 2-layer sandwich domain [IPR018316] 5 7 2.0895229346523223 0.0366606756361753 3.6140776699029127 5.883495145631068 0.537603280896448 0.3771225437200781 1.6631634011190108 1.117390952728082 1.2199662970774952 0.3090115161057067 0.0003792915561059 1.0 1.0 0.3400030327298383 0.0010053263520343 +Tubulin/FtsZ, GTPase domain [IPR003008] 5 7 2.0895229346523223 0.0366606756361753 3.6140776699029127 5.883495145631068 0.537603280896448 0.3771225437200781 1.6631634011190108 1.117390952728082 1.2199662970774952 0.3090115161057067 0.000508394757649 1.0 1.0 0.3559534457378639 0.0013369974246366 +Band 7 domain [IPR001107] 6 7 1.9746404883921191 0.0483089608858686 3.825242718446602 7.354368932038835 0.2848798017769268 0.3662852929750465 1.8717479731706237 0.7075565364256523 1.25010454777189 0.3076860385713043 0.0460411511547768 1.0 1.0 0.1973959389561772 0.0076703518288617 +Peptidase M16, N-terminal [IPR011765] 2 7 1.9673585519977208 0.0491418891833179 2.6067961165048543 7.0 0.7914914082442276 0.4366893661235884 1.5075062759483802 0.0 0.8715475629418188 0.3304871916560691 0.0018641172205925 1.0 0.0653907127050202 0.0112385866308786 0.0034377129995212 +Peptidase M16, C-terminal [IPR007863] 2 7 1.9673585519977208 0.0491418891833179 2.6067961165048543 7.0 0.7914914082442276 0.4366893661235884 1.5075062759483802 0.0 0.8715475629418188 0.3304871916560691 0.0018641172205925 1.0 0.0653907127050202 0.0112385866308786 0.0034377129995212 diff --git a/interpro_domain/metrics.json b/interpro_domain/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..ba759ffe8b88745fc0c9aeebb7d2b50f3088e83f --- /dev/null +++ b/interpro_domain/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3120, + "annotations_size": 2560, + "title": "Average number of proteins per term", + "value": 2.15859375 +} \ No newline at end of file diff --git a/interpro_domain/paths.json b/interpro_domain/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..6898439551a8afb2fc2d1f2fc6c299321fac8a9d --- /dev/null +++ b/interpro_domain/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C390/C390_val_log2fc"} \ No newline at end of file diff --git a/interpro_domain/result.tsv b/interpro_domain/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..09d8c78013145a92331eeb1dc48b8baace6d35a0 --- /dev/null +++ b/interpro_domain/result.tsv @@ -0,0 +1,232 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +P-type ATPase, haloacid dehalogenase domain [IPR044492] 0.8631105398457536 2.7360476652840746 0.0062182018272194 0.9999998838397732 0.3127751556412145 8 P16615,P98194,P20020,P05023,Q04656,Q9HD20,P35670 7 +Intermediate filament, rod domain [IPR039008] 0.8206940874036005 2.539423265749998 0.0111035399638976 0.9999999999996144 0.3127751556412145 8 P20700,P48681,Q03252,Q16352,P07197,P08670,P07196 7 +EF-hand domain [IPR002048] 0.5041369431306325 2.3664690972745497 0.0179586734580241 1.0 0.3127751556412145 42 Q6NUK1,Q9UBV8,Q9NWM8,O95202,Q8NF37,P80303,Q15293,Q02818,O75746,Q9H4M9,P41208,Q96D71,Q9UJS0,Q9BRK5,Q9H223,O43852,Q14257,Q9BPX6,Q8IYU8 19 +Cation-transporting P-type ATPase, C-terminal [IPR006068] 0.8622792937399686 2.268224098030487 0.0233155513984633 1.0 0.3127751556412145 5 P20020,P16615,P98194,P05023 4 +Cation-transporting P-type ATPase, N-terminal [IPR004014] 0.8622792937399686 2.268224098030487 0.0233155513984633 1.0 0.3127751556412145 5 P20020,P16615,P98194,P05023 4 +Cytochrome b5-like heme/steroid binding domain [IPR001199] 0.931757166268923 2.234204434927569 0.0254696247701968 1.0 0.3127751556412145 4 O43169,Q9UMX5 2 +LEM domain [IPR003887] 0.8061358253085664 2.1599450062333303 0.030776927092343 1.0 0.3127751556412145 6 P50402,Q86XL3,Q9Y2U8,P42167 4 +Immunoglobulin-like domain [IPR007110] 0.6440187365292319 2.116601952687457 0.0342936442633112 1.0 0.3142765227988738 13 P10321,P04439,Q08722,P35613,O75962,Q5ZPR3,P78310,P10586 8 +GOLD domain [IPR009038] 0.7670845653884082 2.1020620297116426 0.0355478424592528 1.0 0.3142765227988738 7 Q15363,Q9BVK6,Q9Y3A6,P49755,Q9Y3B3 5 +Tubulin/FtsZ, 2-layer sandwich domain [IPR018316] 0.7644139892546106 2.0895229346523223 0.0366606756361753 1.0 0.3142765227988738 7 Q13885,Q9BVA1,P07437,Q9BUF5,P68371 5 +Tubulin/FtsZ, GTPase domain [IPR003008] 0.7644139892546106 2.0895229346523223 0.0366606756361753 1.0 0.3142765227988738 7 Q13885,Q9BVA1,P07437,Q9BUF5,P68371 5 +Reticulon [IPR003388] 0.8903039513319416 2.0650782084328054 0.0389156009390116 1.0 0.3204685614840465 4 O95197,O75298 2 +Band 7 domain [IPR001107] 0.7401220687439651 1.9746404883921191 0.0483089608858686 1.0 0.3337831506966954 7 O75477,P35232,O94905,Q99623,Q9UJZ1,O75955 6 +Peptidase M16, N-terminal [IPR011765] 0.7385927749789158 1.9673585519977208 0.0491418891833179 1.0 0.3354990332298467 7 Q10713,P22695 2 +Peptidase M16, C-terminal [IPR007863] 0.7385927749789158 1.9673585519977208 0.0491418891833179 1.0 0.3354990332298467 7 Q10713,P22695 2 +Target SNARE coiled-coil homology domain [IPR000727] 0.666589094041113 1.8748251710155437 0.0608167791424465 1.0 0.3612319132358773 9 O15400,Q86Y82,O95721,O60499,O43752,Q12846,Q13190 7 +Intermediate filament head, DNA-binding domain [IPR006821] 0.82894736842104 1.8096946286884377 0.0703431559525675 1.0 0.376700714861263 4 P08670,P07196,Q16352 3 +Dynamin-type guanine nucleotide-binding (G) domain [IPR030381] 0.7086667258805256 1.7105138407319658 0.0871708962473132 1.0 0.4082846393297641 6 Q9H4M9,O95140,O60313 3 +Dynamin, N-terminal [IPR045063] 0.7086667258805256 1.7105138407319658 0.0871708962473132 1.0 0.4082846393297641 6 Q9H4M9,O95140,O60313 3 +Sorting nexin Vps5-like, C-terminal [IPR015404] 0.8050539527732883 1.708750885461934 0.0874971039484222 1.0 0.4082846393297641 4 O60749 1 +Choline/carnitine acyltransferase domain [IPR039551] 0.949326491340603 1.5881568732825069 0.112250870429079 1.0 0.4388529718725426 2 P23786 1 +Immunoglobulin C1-set [IPR003597] 0.764441591784338 1.5355537099764758 0.1246478746361385 1.0 0.4623589448550588 4 P10321,P04439,Q5ZPR3 3 +Peptidase M48 [IPR001915] 0.9281590763309876 1.5003059421585574 0.1335351709349801 1.0 0.4768478479484487 2 O75844 1 +Alpha/beta hydrolase fold-1 [IPR000073] 0.6635466770071682 1.495820454958156 0.1347004494596428 1.0 0.4768478479484487 6 Q9NUJ1,P38571 2 +Zinc finger, RanBP2-type [IPR001876] 0.6107233165504758 1.493476447104051 0.1353125150405922 1.0 0.4768478479484487 8 Q92804,P98175,P35637,P52756 4 +Immunoglobulin subtype [IPR003599] 0.5931149518746635 1.4817597305316363 0.1384042375611982 1.0 0.4768478479484487 9 P35613,O75962,P78310,Q5ZPR3 4 +Immunoglobulin subtype 2 [IPR003598] 0.5931149518746635 1.4817597305316363 0.1384042375611982 1.0 0.4768478479484487 9 P35613,O75962,P78310,Q5ZPR3 4 +GMP phosphodiesterase, delta subunit [IPR008015] 0.921103271327782 1.471018608994737 0.141286084359103 1.0 0.4777970620334264 2 O43924 1 +ABC transporter type 1, transmembrane domain [IPR011527] 0.9054809490010516 1.4667231401015344 0.1424513853740832 1.0 0.4790113612006966 3 O75027 1 +Marvel domain [IPR008253] 0.9143681847338032 1.4430677505139 0.1490013869054842 1.0 0.4934586681475287 2 O43760 1 +ATPase family AAA domain-containing protein 3, N-terminal [IPR021911] 0.9095574085952532 1.4231083739082355 0.1547047412260829 1.0 0.4986341046119511 2 Q9NVI7 1 +Peptidase M1, membrane alanine aminopeptidase [IPR014782] 0.6702116377227508 1.4079887549565422 0.1591343997921734 1.0 0.4986341046119511 5 P55786,Q9UIQ6,Q9NZ08 3 +Aminopeptidase N-like , N-terminal domain [IPR045357] 0.6702116377227508 1.4079887549565422 0.1591343997921734 1.0 0.4986341046119511 5 P55786,Q9UIQ6,Q9NZ08 3 +Alpha-L-fucosidase, C-terminal [IPR031919] 0.9047466324567028 1.4031554358688756 0.1605704932530476 1.0 0.4999125963563519 2 P04066 1 +RBM3/CIRBP, RNA recognition motif [IPR034278] 0.9021808851828164 1.3925170822581088 0.1637658724915489 1.0 0.5064725903478251 2 P98179 1 +ERAP1-like C-terminal domain [IPR024571] 0.8857876162977171 1.389661445379369 0.1646317075850432 1.0 0.5064725903478251 3 P55786,Q9UIQ6 2 +Complex 1 LYR protein domain [IPR008011] 0.8986529826812171 1.3778936045097483 0.1682361398310967 1.0 0.5066876681971855 2 Q9Y6M9 1 +SH3 domain [IPR001452] 0.401388254585435 1.3642386053047988 0.1724924815818038 1.0 0.5104979801727374 40 Q96RU3,Q5JRA6,Q92783,Q9NZW5,Q96PC5,Q9H6R6,Q00013,O00459,Q9Y371,P20936,Q14847,Q9UQB8,O75962,P46108,Q14168,Q14185 16 +Zinc finger, CCHC-type [IPR001878] 0.6325963644546376 1.3466163482068874 0.1781038261720602 1.0 0.5143672696178634 6 Q16629,Q9NUD5 2 +Major facilitator superfamily domain [IPR020846] 0.6560893448751185 1.3424536284435429 0.1794489562398729 1.0 0.5165278612851285 5 Q9NY64 1 +Ricin B, lectin domain [IPR000772] 0.719002212111152 1.3399807024753747 0.180251618830384 1.0 0.5165278612851285 4 Q10472 1 +Fatty acid hydroxylase [IPR006694] 0.8877485567671579 1.3327321841799835 0.1826197075227158 1.0 0.5217705929220453 2 Q15800 1 +Metaxin, glutathione S-transferase domain [IPR033468] 0.8851828094932795 1.3221160574230244 0.1861295075541953 1.0 0.5294350437097112 2 Q13505 1 +Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564] 0.8851828094932795 1.3221160574230244 0.1861295075541953 1.0 0.5294350437097112 2 Q13505 1 +Sterol-sensing domain [IPR000731] 0.8649342316329784 1.3080595934232562 0.190853097156268 1.0 0.5369054161758751 3 O15118,Q12770 2 +Immunoglobulin V-set domain [IPR013106] 0.7059880489089587 1.2837698011950676 0.1992225129622964 1.0 0.5414115001947758 4 P78310 1 +Heavy metal-associated domain, copper ion-binding [IPR006122] 0.8726747915330345 1.2704320630502226 0.2039307681959257 1.0 0.5490976129259266 2 P35670 1 +Heavy metal-associated domain, HMA [IPR006121] 0.8726747915330345 1.2704320630502226 0.2039307681959257 1.0 0.5490976129259266 2 P35670 1 +FAD linked oxidase, N-terminal [IPR006094] 0.871391917896088 1.2651385806618702 0.2058216548930707 1.0 0.5492448068484684 2 O00116 1 +FAD-binding domain, PCMH-type [IPR016166] 0.871391917896088 1.2651385806618702 0.2058216548930707 1.0 0.5492448068484684 2 O00116 1 +Phospholipase D/Transphosphatidylase [IPR001736] 0.8691468890314449 1.2558787294392235 0.2091599415498852 1.0 0.5525794121441757 2 Q8IV08 1 +Plasma membrane calcium transporting P-type ATPase, C-terminal [IPR022141] 0.8614496472097508 1.2241697478436695 0.2208881988693567 1.0 0.559988121413887 2 P20020 1 +Syntaxin 6, N-terminal [IPR015260] 0.8611289288005299 1.222849944902407 0.2213863772609108 1.0 0.559988121413887 2 O60499 1 +Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862] 0.8608082103912842 1.2215302603931086 0.2218853155099061 1.0 0.559988121413887 2 Q32P28 1 +Man1/Src1, C-terminal [IPR018996] 0.8588838999358559 1.213614680325004 0.2248948984904886 1.0 0.5608984718470009 2 Q9Y2U8 1 +Lamin tail domain [IPR001322] 0.8193776066730817 1.1303912421760849 0.2583114027736037 1.0 0.6089108573668744 3 P20700,Q03252 2 +Phospholipid/glycerol acyltransferase [IPR002123] 0.5829438086194203 1.1052145067619623 0.2690666524034237 1.0 0.6217136204008834 6 Q8NF37,Q9NUQ2 2 +SUN coiled coil domain 2 [IPR040994] 0.8322642719692112 1.1046436110732898 0.2693140461167997 1.0 0.6217136204008834 2 Q9UH99 1 +Fibronectin type II domain [IPR000562] 0.8127088634088742 1.104522994598588 0.269366334404014 1.0 0.6217136204008834 3 Q9UBV2 1 +Zinc finger, CHHC-type [IPR012996] 0.8116778954122539 1.100528358975971 0.2711019804821171 1.0 0.6217136204008834 3 P55795,P31943 2 +ABC transporter-like, ATP-binding domain [IPR003439] 0.5569203774798983 1.0666529256909665 0.2861285915877549 1.0 0.6411501089021425 7 O75027 1 +Zinc finger C2H2 AKAP95-type [IPR034736] 0.7939669385472305 1.032123997302596 0.3020140333731704 1.0 0.6530033154014496 3 Q9ULX6 1 +L27 domain [IPR004172] 0.6412066752246299 1.004520115224254 0.3151279805453857 1.0 0.6694835105362551 4 Q14168,O14936,Q9NZW5 3 +Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337] 0.8062860808210388 0.99956007989521 0.3175234502644071 1.0 0.6717851509726299 2 O60506 1 +Glycoside hydrolase family 20, catalytic domain [IPR015883] 0.8053239255933463 0.9956984460629288 0.3193966853674606 1.0 0.6727469856751668 2 P06865 1 +Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019] 0.8053239255933463 0.9956984460629288 0.3193966853674606 1.0 0.6727469856751668 2 P06865 1 +PSI domain [IPR016201] 0.799550994227068 0.9725806503769104 0.3307617633405506 1.0 0.6799047186420561 2 P05556 1 +CARG-binding factor, N-terminal [IPR012956] 0.7973059653624112 0.963615345798956 0.3352388102215364 1.0 0.682603563920452 2 Q99729 1 +Syntaxin, N-terminal domain [IPR006011] 0.7712544112928964 0.9451581165392944 0.3445781586563963 1.0 0.6923115932715822 3 Q12846,O15400 2 +DnaJ domain [IPR001623] 0.4131624499448728 0.942233513789178 0.3460730991046543 1.0 0.6937722268660259 18 Q13217,Q9Y2G8,Q9UGP8,Q96KC8 4 +Zinc finger, TFIIB-type [IPR013137] 0.7908915971776813 0.9380816071785688 0.3482024732278717 1.0 0.6971771047434967 2 P29083 1 +FAD dependent oxidoreductase [IPR006076] 0.7686878408726099 0.935395975401612 0.3495842702305727 1.0 0.6977744256104422 3 Q96CU9,Q9H9P8 2 +SWIRM domain [IPR007526] 0.6230805236288062 0.9271474734671742 0.3538499705068447 1.0 0.7022138949593199 4 Q8NB78 1 +Peptidase M41 [IPR000642] 0.7873636946760736 0.9240918947173076 0.3554384729456581 1.0 0.7042743736384558 2 Q9Y4W6 1 +MHC class I alpha chain, alpha1 alpha2 domains [IPR001039] 0.7641963426371582 0.9183484135225084 0.3584364887148501 1.0 0.7067490231242598 3 P10321,P04439 2 +MHC class I, alpha chain, C-terminal [IPR010579] 0.7641963426371582 0.9183484135225084 0.3584364887148501 1.0 0.7067490231242598 3 P10321,P04439 2 +MHC class I-like antigen recognition-like [IPR011161] 0.7641963426371582 0.9183484135225084 0.3584364887148501 1.0 0.7067490231242598 3 P10321,P04439 2 +NOPS [IPR012975] 0.7619505935194094 0.909842581703404 0.3629055343746175 1.0 0.7067490231242598 3 P23246,Q8WXF1 2 +MRH domain [IPR044865] 0.7579285276276021 0.8946401479983707 0.3709794828717094 1.0 0.7103272072936248 3 P20645 1 +Peptidase M28 [IPR007484] 0.7571382739813944 0.8916580286928709 0.3725762565613122 1.0 0.7128514325836766 3 P02786,Q969V3 2 +TRAM/LAG1/CLN8 homology domain [IPR006634] 0.7774214239897528 0.8848875915962534 0.3762172610440744 1.0 0.7182074483764582 2 Q15629 1 +Legume-like lectin [IPR005052] 0.7761385503527891 0.8798540523680861 0.3789383785411142 1.0 0.7207148952936496 2 Q12907 1 +N-acetylgalactosaminyltransferase [IPR045885] 0.7732520846696862 0.8685506078045404 0.3850929802238485 1.0 0.7273231192116618 2 Q10472 1 +EH domain-containing protein, N-terminal [IPR031692] 0.7697241821680552 0.8547778030897675 0.3926741687526647 1.0 0.7288575917313943 2 Q9H4M9 1 +Domain of unknown function DUF5600 [IPR040990] 0.7697241821680552 0.8547778030897675 0.3926741687526647 1.0 0.7288575917313943 2 Q9H4M9 1 +Cyclic nucleotide-binding domain [IPR000595] 0.5460981675643182 0.8317341573423771 0.4055590160077054 1.0 0.7354194965255384 5 Q6P4Q7 1 +OCRE domain [IPR041591] 0.7402564966679867 0.8283666010765561 0.4074629152614664 1.0 0.7354194965255384 3 P52756 1 +MCM, AAA-lid domain [IPR041562] 0.5255185569075023 0.8265316911399233 0.4085025484606701 1.0 0.7354194965255384 6 Q14566 1 +MCM OB domain [IPR033762] 0.5255185569075023 0.8265316911399233 0.4085025484606701 1.0 0.7354194965255384 6 Q14566 1 +MCM domain [IPR001208] 0.5255185569075023 0.8265316911399233 0.4085025484606701 1.0 0.7354194965255384 6 Q14566 1 +MCM N-terminal domain [IPR027925] 0.5255185569075023 0.8265316911399233 0.4085025484606701 1.0 0.7354194965255384 6 Q14566 1 +PDZ domain [IPR001478] 0.3803348431338538 0.8110383601025564 0.417343641954718 1.0 0.7391551596343375 20 O43464,Q00013,O00560,P57105,Q14168 5 +Autophagy-related, C-terminal [IPR015412] 0.7543296985246934 0.7952675606454707 0.4264578792109048 1.0 0.7391551596343375 2 Q709C8 1 +Vacuolar protein sorting-associated protein 13, second N-terminal domain [IPR031646] 0.7543296985246934 0.7952675606454707 0.4264578792109048 1.0 0.7391551596343375 2 Q709C8 1 +Vacuolar protein sorting-associated protein 13, SHR-binding domain [IPR009543] 0.7543296985246934 0.7952675606454707 0.4264578792109048 1.0 0.7391551596343375 2 Q709C8 1 +Vacuolar protein sorting-associated protein 13-like, N-terminal domain [IPR026854] 0.7543296985246934 0.7952675606454707 0.4264578792109048 1.0 0.7391551596343375 2 Q709C8 1 +VPS13, repeated coiled region [IPR031642] 0.7543296985246934 0.7952675606454707 0.4264578792109048 1.0 0.7391551596343375 2 Q709C8 1 +Vacuolar protein sorting-associated protein 13, C-terminal [IPR031645] 0.7543296985246934 0.7952675606454707 0.4264578792109048 1.0 0.7391551596343375 2 Q709C8 1 +Tim44-like domain [IPR007379] 0.7501603592046165 0.7793280984705657 0.4357864667933806 1.0 0.742751900792979 2 O43615 1 +Armadillo repeat-containing domain [IPR006911] 0.7495189223861431 0.7768830437493716 0.4372277760589573 1.0 0.7432291545225305 2 Q9UH62 1 +Ion transporter-like, CBS domain [IPR044751] 0.7456703014753088 0.7622539580604624 0.4459084475806301 1.0 0.7514981078383233 2 Q6P4Q7 1 +CNNM, transmembrane domain [IPR002550] 0.7456703014753088 0.7622539580604624 0.4459084475806301 1.0 0.7514981078383233 2 Q6P4Q7 1 +Far upstream element-binding protein, C-terminal [IPR015096] 0.7431045542014092 0.7525413700425085 0.4517255608611406 1.0 0.7543492731927722 2 Q96AE4 1 +Oxoglutarate/iron-dependent dioxygenase [IPR005123] 0.5251974176389436 0.7367837079252172 0.4612538923318459 1.0 0.7565263271105991 5 Q32P28 1 +Prolyl 4-hydroxylase, alpha subunit [IPR006620] 0.5251974176389436 0.7367837079252172 0.4612538923318459 1.0 0.7565263271105991 5 Q32P28 1 +Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal [IPR018955] 0.710619185113891 0.7195343396595459 0.4718117518621465 1.0 0.7629136329159144 3 Q15118,Q15120 2 +Histidine kinase domain [IPR005467] 0.710619185113891 0.7195343396595459 0.4718117518621465 1.0 0.7629136329159144 3 Q15118,Q15120 2 +Proteasome activator PA28, N-terminal domain [IPR003185] 0.7086942572986783 0.7125840507061497 0.4761031840298393 1.0 0.7655930597464753 3 P61289,Q9UL46 2 +Proteasome activator PA28, C-terminal domain [IPR003186] 0.7086942572986783 0.7125840507061497 0.4761031840298393 1.0 0.7655930597464753 3 P61289,Q9UL46 2 +Arf GTPase activating protein [IPR001164] 0.7322001282873615 0.7116402634821991 0.4766875675671882 1.0 0.7660515837865673 2 Q8N6T3 1 +Class II aldolase/adducin N-terminal [IPR001303] 0.7270686337395744 0.692615948797198 0.4885505987827829 1.0 0.7742355517310324 2 P35611 1 +Chromo domain subgroup [IPR017984] 0.701636188642924 0.687239072367404 0.4919320861004332 1.0 0.7752749949349175 3 Q13185,P45973 2 +Chromo shadow domain [IPR008251] 0.701636188642924 0.687239072367404 0.4919320861004332 1.0 0.7752749949349175 3 Q13185,P45973 2 +PB1 domain [IPR000270] 0.725465041693391 0.6867016603605939 0.4922707504634087 1.0 0.7752749949349175 2 Q13501 1 +Sterile alpha motif domain [IPR001660] 0.495504174694938 0.683520728074927 0.4942778568473231 1.0 0.7763124292988065 6 Q15375,Q9Y3Z3,Q13136,Q9Y6Y8,Q8IXK0 5 +SCP2 sterol-binding domain [IPR003033] 0.6965030478023723 0.6689500410373761 0.5035273473780708 1.0 0.786473465093265 3 P22307,Q6YN16 2 +Rho GTPase-activating protein domain [IPR000198] 0.5592375526496844 0.6617976142145944 0.5081009353411421 1.0 0.7903702489339048 4 O00459 1 +Acyl-CoA oxidase, C-terminal [IPR002655] 0.7180885182809715 0.6596924841978095 0.5094511907471833 1.0 0.7903702489339048 2 Q15067 1 +Hexokinase, C-terminal [IPR022673] 0.7174470814625031 0.6573595275132368 0.5109497688022031 1.0 0.7903702489339048 2 P52789 1 +Hexokinase, N-terminal [IPR022672] 0.7174470814625031 0.6573595275132368 0.5109497688022031 1.0 0.7903702489339048 2 P52789 1 +L27 domain, C-terminal [IPR014775] 0.6897658004491455 0.6451399744723221 0.5188364808378438 1.0 0.7953421502663953 3 Q14168,Q9NZW5 2 +Heat shock chaperonin-binding [IPR006636] 0.483543102588765 0.6275191475422597 0.5303189889563091 1.0 0.8023738840000896 6 P54727,Q9UHD9,Q9NRR5 3 +Major sperm protein (MSP) domain [IPR000535] 0.6718860167738868 0.5831165040858051 0.5598148741435278 1.0 0.8206048375459376 3 Q8NHP6 1 +Guanylate kinase/L-type calcium channel beta subunit [IPR008145] 0.4592951848080729 0.5766335124935358 0.5641870554600921 1.0 0.8226955474591521 7 Q14168,Q00013 2 +Guanylate kinase-like domain [IPR008144] 0.4592951848080729 0.5766335124935358 0.5641870554600921 1.0 0.8226955474591521 7 Q14168,Q00013 2 +Zinc finger, CW-type [IPR011124] 0.6914688903143118 0.5651809086120597 0.5719507207928771 1.0 0.828104052082417 2 Q8NB78 1 +Glycosyltransferase 2-like [IPR001173] 0.6604610031548539 0.5444627620315858 0.5861230667215298 1.0 0.835453814480577 3 Q10472 1 +Aldehyde dehydrogenase domain [IPR015590] 0.4222879963146634 0.5430789796987616 0.5870754247657917 1.0 0.8355424597134864 9 P51648 1 +Acyltransferase, C-terminal domain [IPR032098] 0.6831302116741607 0.5366345642675623 0.5915200639188809 1.0 0.8370875420853151 2 Q9NUQ2 1 +Fatty acid desaturase domain [IPR005804] 0.6815266196279633 0.5312080534870416 0.5952746127769541 1.0 0.8407259250626883 2 O95864 1 +ELMO domain [IPR006816] 0.6789608723540941 0.5225692402369079 0.6012740507641163 1.0 0.8441841537113314 2 Q8IZ81 1 +RNA binding activity-knot of a chromodomain [IPR025995] 0.6728672225785726 0.5022721020657671 0.6154761305302783 1.0 0.8489325938348666 2 Q9UBU8 1 +EB1, C-terminal [IPR004953] 0.6703014753046788 0.4938208777722779 0.6214326872003304 1.0 0.8508193452201511 2 Q15555 1 +U2A'/phosphoprotein 32 family A, C-terminal [IPR003603] 0.6696600384862085 0.4917170382974885 0.6229193916348488 1.0 0.8514007702003271 2 Q92688 1 +Extended synaptotagmin, C2A domain [IPR037733] 0.6664528543938385 0.4812523692096672 0.6303371448891792 1.0 0.8551473719747212 2 A0FGR8 1 +Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468] 0.6664528543938385 0.4812523692096672 0.6303371448891792 1.0 0.8551473719747212 2 A0FGR8 1 +Synaptotagmin, SMP domain [IPR039010] 0.6664528543938385 0.4812523692096672 0.6303371448891792 1.0 0.8551473719747212 2 A0FGR8 1 +Extended synaptotagmin, C2B domain [IPR037749] 0.6664528543938385 0.4812523692096672 0.6303371448891792 1.0 0.8551473719747212 2 A0FGR8 1 +Extended synaptotagmin, C-terminal C2 domain [IPR037752] 0.6664528543938385 0.4812523692096672 0.6303371448891792 1.0 0.8551473719747212 2 A0FGR8 1 +CBS domain [IPR000644] 0.4484793438043655 0.4682546330965952 0.6396025070531406 1.0 0.8604216595144718 6 Q6P4Q7,P51790 2 +Amino acid permease/ SLC12A domain [IPR004841] 0.6587556125721588 0.4565168720772241 0.6480183409932256 1.0 0.8645126971032674 2 P55011 1 +SLC12A transporter, C-terminal [IPR018491] 0.6587556125721588 0.4565168720772241 0.6480183409932256 1.0 0.8645126971032674 2 P55011 1 +14-3-3 domain [IPR023410] 0.4457289659601848 0.4561499034339971 0.6482821868260846 1.0 0.8645126971032674 6 P62258,Q04917,P31946,P61981,P63104 5 +ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain [IPR044728] 0.6536241180243928 0.4403340444621568 0.6596951868007606 1.0 0.8699372215003541 2 Q14240 1 +FAD/NAD(P)-binding domain [IPR023753] 0.455511998982988 0.4364009972783361 0.6625458155259532 1.0 0.8708415584287841 5 O95831 1 +Phox homology [IPR001683] 0.4011637694958569 0.4331957652450436 0.6648725551137589 1.0 0.8710715153998069 9 O60749 1 +RNA recognition motif domain, eukaryote [IPR003954] 0.375127049781502 0.4183435944114434 0.6756959204137027 1.0 0.8722937160797862 12 Q14011,Q9UHX1 2 +Fragile X-related 1 protein, C-terminal core [IPR022034] 0.6456061577934531 0.4155609196597404 0.6777313286260527 1.0 0.8722937160797862 2 P51116 1 +Synaptic functional regulator FMRP, KH0 domain [IPR040472] 0.6456061577934531 0.4155609196597404 0.6777313286260527 1.0 0.8722937160797862 2 P51116 1 +Fragile X-related 1 protein, C-terminal region 1 [IPR032172] 0.6456061577934531 0.4155609196597404 0.6777313286260527 1.0 0.8722937160797862 2 P51116 1 +Agenet-like domain [IPR008395] 0.6456061577934531 0.4155609196597404 0.6777313286260527 1.0 0.8722937160797862 2 P51116 1 +Fxr1, tudor domain [IPR041560] 0.6456061577934531 0.4155609196597404 0.6777313286260527 1.0 0.8722937160797862 2 P51116 1 +Acyl-CoA-binding protein, ACBP [IPR000582] 0.6289288005131448 0.3661449829219831 0.7142568930227418 1.0 0.8846142458336812 2 Q9H3P7 1 +UBX domain [IPR001012] 0.4191751398009222 0.3430473129715396 0.7315628667444622 1.0 0.8913855016020101 6 Q96CS3,O94888 2 +EH domain [IPR000261] 0.416410758542861 0.2863879493021181 0.7745810034216751 1.0 0.9039117344937514 5 Q96D71,Q9H4M9 2 +v-SNARE, coiled-coil homology domain [IPR042855] 0.5360296168690051 0.1942467443063497 0.845982683181215 1.0 0.9322925824123592 3 O75396 1 +Longin domain [IPR010908] 0.5360296168690051 0.1942467443063497 0.845982683181215 1.0 0.9322925824123592 3 O75396 1 +YTH domain [IPR007275] 0.5580500320718353 0.1925798459558121 0.8472880300548071 1.0 0.9329278954581962 2 Q96MU7 1 +Flavoprotein pyridine nucleotide cytochrome reductase [IPR001709] 0.533081492039295 0.1879291209057812 0.8509322142538598 1.0 0.9337275904371544 3 P16435 1 +Oxidoreductase FAD/NAD(P)-binding [IPR001433] 0.533081492039295 0.1879291209057812 0.8509322142538598 1.0 0.9337275904371544 3 P16435 1 +FAD-binding domain, ferredoxin reductase-type [IPR017927] 0.533081492039295 0.1879291209057812 0.8509322142538598 1.0 0.9337275904371544 3 P16435 1 +Adenylate kinase, active site lid domain [IPR007862] 0.5522771007055741 0.1812858647944552 0.8561432004630964 1.0 0.9366352962331312 2 P27144 1 +Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958] 0.5245428296438965 0.1702313725732733 0.8648281800395003 1.0 0.939698171404224 3 Q9NRG0,Q9NR33 2 +Exosome complex component, N-terminal domain [IPR025721] 0.5455420141116034 0.1686736313493046 0.8660533607018368 1.0 0.939698171404224 2 Q9Y3B2 1 +Heat shock protein Hsp90, N-terminal [IPR020575] 0.4082156611039822 0.1525943600492813 0.8787181729390967 1.0 0.9435899843641308 4 P07900,P14625,Q12931 3 +UAS [IPR006577] 0.5148948757239215 0.1513198523866374 0.8797234096603006 1.0 0.9438775895768524 3 Q96CS3 1 +cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117] 0.5311096856959532 0.1436931392035492 0.8857427890965717 1.0 0.9492223805292876 2 P13861 1 +NECAP, PHear domain [IPR012466] 0.527902501603585 0.1385192250391934 0.8898300766929288 1.0 0.9515309090784868 2 Q9NVZ3 1 +GYF domain [IPR003169] 0.5253367543296915 0.1344782393102756 0.893024417295027 1.0 0.9533386409401164 2 O95400 1 +Cobalamin (vitamin B12)-binding domain [IPR006158] 0.5246953175112181 0.1334815854040452 0.8938125266635537 1.0 0.9533386409401164 2 Q99707 1 +Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2 [IPR034798] 0.5169980756895376 0.1219433864625659 0.9029438545779214 1.0 0.9599403105147336 2 P26599 1 +Dbl homology (DH) domain [IPR000219] 0.3860718870346706 0.1025868307551662 0.9182908952252076 1.0 0.9710139164710994 4 Q14155,O94887,O75962 3 +Sec23, C-terminal [IPR037550] 0.5003207184092308 0.0995682544846086 0.920687097799154 1.0 0.9729946099026348 2 Q15436 1 +Protein kinase, C-terminal [IPR017892] 0.3509955041746909 0.0961975772065381 0.9233636550017392 1.0 0.9747674048678154 6 P51812,Q05655,Q16513,Q15418,P31751 5 +FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179] 0.331221498622832 0.0935035115423586 0.9255035601112452 1.0 0.9766237072896898 8 Q9NWM8,Q02790 2 +AP complex, mu/sigma subunit [IPR022775] 0.3534510433386879 0.0909686945159704 0.9275174660470812 1.0 0.9768026936978738 5 Q9Y2T2,P53680,P61923,P48444 4 +RNA-binding protein Musashi homologue, RNA recognition motif 1 [IPR034130] 0.4916613213598396 0.0893248180279078 0.9288237709695236 1.0 0.9768026936978738 2 Q96DH6 1 +RNA-binding protein Musashi homologue, RNA recognition motif 2 [IPR034126] 0.4916613213598396 0.0893248180279078 0.9288237709695236 1.0 0.9768026936978738 2 Q96DH6 1 +GTPase effector domain [IPR020850] 0.4906991661321282 0.0882429420638139 0.9296835875838516 1.0 0.9768026936978738 2 P50570 1 +Dynamin GTPase effector [IPR003130] 0.4906991661321282 0.0882429420638139 0.9296835875838516 1.0 0.9768026936978738 2 P50570 1 +Dynamin stalk domain [IPR000375] 0.4906991661321282 0.0882429420638139 0.9296835875838516 1.0 0.9768026936978738 2 P50570 1 +CRIB domain [IPR000095] 0.4900577293136547 0.0875278612610543 0.9302519403263344 1.0 0.9768026936978738 2 O96013 1 +p21 activated kinase binding domain [IPR033923] 0.4900577293136547 0.0875278612610543 0.9302519403263344 1.0 0.9768026936978738 2 O96013 1 +CALCOCO1/2, zinc finger UBZ1-type [IPR041641] 0.4878127004489978 0.0850637399958413 0.9322107170794988 1.0 0.9768560932147018 2 Q9P1Z2 1 +Calcium binding and coiled-coil domain-like [IPR012852] 0.4878127004489978 0.0850637399958413 0.9322107170794988 1.0 0.9768560932147018 2 Q9P1Z2 1 +SKICH domain [IPR041611] 0.4878127004489978 0.0850637399958413 0.9322107170794988 1.0 0.9768560932147018 2 Q9P1Z2 1 +Amine oxidase [IPR002937] 0.4735322425409134 0.0834580648324836 0.9334873204339892 1.0 0.977793592598614 3 P50336,Q8NB78 2 +Zinc finger, UBP-type [IPR001607] 0.3756387192070441 0.0817928408460057 0.9348114491769496 1.0 0.978101453120332 4 Q7Z569,P45974 2 +GRAM domain [IPR004182] 0.4846055163566352 0.0816469770753038 0.9349274436661924 1.0 0.978101453120332 2 Q969T9 1 +Plectin/S10, N-terminal [IPR005326] 0.4836433611289251 0.0806454452373138 0.935723923807782 1.0 0.9781919117676896 2 P46783 1 +Immunoglobulin I-set [IPR013098] 0.3749996137732891 0.0805772970122155 0.9357781218433874 1.0 0.9781919117676896 4 O75962,P10586 2 +Mab-21 domain [IPR024810] 0.4801154586273171 0.0770648348115183 0.9385719675313275 1.0 0.9803118061526718 2 Q9NQG6 1 +E3 ligase, CCCH-type zinc finger [IPR041367] 0.4788325849903713 0.0757981775256036 0.9395796660794375 1.0 0.9809640885658076 2 Q9UPT8 1 +DZF domain [IPR006561] 0.3690629011553296 0.0696074786745025 0.9445060842602384 1.0 0.9832563738784276 4 Q12906,Q12905,Q96SI9 3 +GAR domain [IPR003108] 0.4711353431686956 0.0685860908863894 0.9453190906584334 1.0 0.9832563738784276 2 Q9UPN3 1 +DBC1/CARP1 catalytically inactive NUDIX hydrolase domain [IPR025954] 0.470493906350219 0.0680145762601414 0.9457740309766844 1.0 0.9832563738784276 2 Q8N163 1 +LAIKA domain [IPR045353] 0.470493906350219 0.0680145762601414 0.9457740309766844 1.0 0.9832563738784276 2 Q8N163 1 +S1-like RNA binding domain [IPR025223] 0.470493906350219 0.0680145762601414 0.9457740309766844 1.0 0.9832563738784276 2 Q8N163 1 +BURAN domain [IPR045354] 0.470493906350219 0.0680145762601414 0.9457740309766844 1.0 0.9832563738784276 2 Q8N163 1 +CELF1/2, RNA recognition motif 1 [IPR034196] 0.4701731879409794 0.0677304927473649 0.9460001753369404 1.0 0.9832563738784276 2 O95319 1 +CELF1/2, RNA recognition motif 2 [IPR034198] 0.4701731879409794 0.0677304927473649 0.9460001753369404 1.0 0.9832563738784276 2 O95319 1 +CELF1/2, RNA recognition motif 3 [IPR034199] 0.4701731879409794 0.0677304927473649 0.9460001753369404 1.0 0.9832563738784276 2 O95319 1 +SUN domain [IPR012919] 0.4608085508120833 0.0668435675193291 0.9467062390818652 1.0 0.9835908977473924 3 Q9UH99 1 +AMP-dependent synthetase/ligase [IPR000873] 0.3428571428571468 0.0650037313980638 0.9481710293144564 1.0 0.9843138017214148 5 O95573,Q6P1M0,P33121,O60488 4 +Peptidase M3A/M3B catalytic domain [IPR001567] 0.4581328200192496 0.0635966393329192 0.9492914077509058 1.0 0.9850774235274904 3 Q9BYT8,Q99797 2 +Ku70/Ku80, N-terminal alpha/beta [IPR005161] 0.4525336754329619 0.053759645545207 0.9571266611883332 1.0 0.991199131327724 2 P12956 1 +Ku70/Ku80 beta-barrel domain [IPR006164] 0.4525336754329619 0.053759645545207 0.9571266611883332 1.0 0.991199131327724 2 P12956 1 +Ku70/Ku80 C-terminal arm [IPR005160] 0.4525336754329619 0.053759645545207 0.9571266611883332 1.0 0.991199131327724 2 P12956 1 +Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120] 0.4464400256574654 0.0496483680888315 0.960402601970788 1.0 0.9926952469123216 2 Q9Y305 1 +FF domain [IPR002713] 0.4361770365618917 0.0434853759487206 0.9653146218015536 1.0 0.9933670334340964 2 O75400 1 +Mu homology domain [IPR028565] 0.3533376123234999 0.0433424088190161 0.9654285856187624 1.0 0.9933670334340964 4 Q9BXS5,P48444,Q9Y2T2 3 +NudC N-terminal domain [IPR025934] 0.4134060295060852 0.0328512764934559 0.973793187527781 1.0 0.9989628872703772 2 Q9Y266 1 +Gamma tubulin complex component, C-terminal [IPR040457] 0.412764592687614 0.0326059623547174 0.9739888150886178 1.0 0.9989628872703772 2 Q9BSJ2 1 +Gamma tubulin complex component protein, N-terminal [IPR041470] 0.412764592687614 0.0326059623547174 0.9739888150886178 1.0 0.9989628872703772 2 Q9BSJ2 1 +Kinesin-associated [IPR032405] 0.4047466324566984 0.0297625634150401 0.9762564155977628 1.0 1.0 2 Q15058 1 +Fibronectin type III [IPR003961] 0.3239213506839039 0.0240457286708706 0.9808161330340064 1.0 1.0 5 Q15375 1 +RABX5, catalytic core helical domain [IPR041545] 0.3835792174470755 0.0240137346349209 0.9808416532122308 1.0 1.0 2 Q14C86 1 +VPS9 domain [IPR003123] 0.3835792174470755 0.0240137346349209 0.9808416532122308 1.0 1.0 2 Q14C86 1 +Ribosome receptor lysine/proline rich [IPR007794] 0.3287363694676017 0.0171480069505246 0.986318540523894 1.0 1.0 2 Q86UP2 1 +EF-hand, Ca insensitive [IPR014837] 0.4071222329162652 0.0168318660028307 0.9865707481005596 1.0 1.0 3 Q13813,O43707 2 +Copine, C2B domain [IPR037768] 0.2838357921744662 0.015730949485784 0.9874490359300508 1.0 1.0 2 O75131 1 +Copine, C-terminal [IPR010734] 0.2838357921744662 0.015730949485784 0.9874490359300508 1.0 1.0 2 O75131 1 +VHS domain [IPR002014] 0.3332526164526609 0.0155565927854348 0.987588135427373 1.0 1.0 4 Q92783,O14964 2 +Disulphide isomerase [IPR005788] 0.317495987158913 0.0117506395008171 0.9906245619194542 1.0 1.0 5 Q8NBS9,P13667,Q15084,P07237 4 +B-box-type zinc finger [IPR000315] 0.319524727039169 0.010845339802277 0.9913468404482184 1.0 1.0 6 P19474,O60858,Q12899,O15344,Q13263 5 +Tyrosine-specific protein phosphatase, PTPase domain [IPR000242] 0.3955138283719797 0.0097700453201155 0.9922047556951958 1.0 1.0 3 P18031 1 +Protein-tyrosine phosphatase, catalytic [IPR003595] 0.3955138283719797 0.0097700453201155 0.9922047556951958 1.0 1.0 3 P18031 1 +Zinc finger, ZZ-type [IPR000433] 0.3869104908565923 0.0052595700925606 0.9958034895747598 1.0 1.0 3 P46939,Q13501 2 +ARID DNA-binding domain [IPR001606] 0.3811357074109737 0.0025518882016442 0.9979638900129166 1.0 1.0 3 P29375,Q4LE39 2 +Heat shock protein DnaJ, cysteine-rich domain [IPR001305] 0.3808148861084363 0.002408651190108 0.9980781762613292 1.0 1.0 3 Q96EY1,O60884 2 +MIT domain [IPR007330] 0.3763233878729565 0.000480048216981 0.9996169769539408 1.0 1.0 3 O75351,Q8N0X7 2 diff --git a/interpro_domain/selections.json b/interpro_domain/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..0e14691bc0ec38ef831230c1a53fef60317f31c9 --- /dev/null +++ b/interpro_domain/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1-acyl-sn-glycerol-3-phosphate acyltransferase [IPR004552]", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain [IPR035724]", "116kDa U5 small nuclear ribonucleoprotein component, C-terminal [IPR035655]", "116kDa U5 small nuclear ribonucleoprotein component, N-terminal [IPR031950]", "14-3-3 domain [IPR023410]", "16S/18S rRNA aminocarboxypropyltransferase Tsr3, C-terminal [IPR007177]", "18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23, C-terminal [IPR022238]", "2-oxoacid dehydrogenase acyltransferase, catalytic domain [IPR001078]", "2-oxoglutarate dehydrogenase E1 component, N-terminal domain [IPR032106]", "26S proteasome non-ATPase regulatory subunit RPN1, C-terminal [IPR041433]", "26S proteasome regulatory subunit RPN2, C-terminal [IPR040623]", "26S proteasome regulatory subunit RPN5, C-terminal domain [IPR040896]", "26S proteasome regulatory subunit Rpn6, N-terminal [IPR040773]", "26S proteasome regulatory subunit Rpn7, N-terminal [IPR045135]", "26S proteasome regulatory subunit, C-terminal [IPR013586]", "2Fe-2S ferredoxin-type iron-sulfur binding domain [IPR001041]", "3'-5' exonuclease domain [IPR002562]", "3-beta hydroxysteroid dehydrogenase/isomerase [IPR002225]", "3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108]", "3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176]", "3-hydroxyisobutyrate dehydrogenase, NAD-binding domain [IPR029154]", "3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal [IPR001104]", "3-oxoacid CoA-transferase, subunit A [IPR012792]", "3-oxoacid CoA-transferase, subunit B [IPR012791]", "4'-phosphopantetheinyl transferase domain [IPR008278]", "40S ribosomal protein S11, N-terminal [IPR032440]", "40S ribosomal protein S4, C-terminal domain [IPR032277]", "40S ribosomal protein SA, C-terminal domain [IPR032281]", "4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]", "5'-AMP-activated protein kinase catalytic subunit alpha-2, C-terminal [IPR039148]", "6-phosphogluconate dehydrogenase, C-terminal [IPR006114]", "6-phosphogluconate dehydrogenase, NADP-binding [IPR006115]", "6-phosphogluconolactonase, DevB-type [IPR005900]", "60S ribosomal protein L10P, insertion domain [IPR040637]", "60S ribosomal protein L4, C-terminal domain [IPR025755]", "6S proteasome subunit Rpn6, C-terminal helix domain [IPR040780]", "A kinase-anchoring protein AKAP5 and AKAP12, calmodulin (CaM)-binding motif [IPR001573]", "AAA ATPase, AAA+ lid domain [IPR041569]", "AAA+ ATPase domain [IPR003593]", "AAR2, C-terminal [IPR033648]", "AAR2, N-terminal [IPR033647]", "AARP2CN [IPR012948]", "AATF leucine zipper-containing domain [IPR025160]", "ABC transporter type 1, transmembrane domain [IPR011527]", "ABC transporter-like, ATP-binding domain [IPR003439]", "ABC-transporter extension domain [IPR032781]", "ABC1 atypical kinase-like domain [IPR004147]", "ADAR1, first double-stranded RNA binding domain [IPR044456]", "ADAR1, third double-stranded RNA binding domain [IPR044457]", "ADCK3-like domain [IPR034646]", "ADNP, zinc finger domain [IPR045762]", "AGC-kinase, C-terminal [IPR000961]", "AIMP2, lysyl-tRNA synthetase binding domain [IPR031889]", "AIMP2, thioredoxin-like domain [IPR041503]", "ALIX V-shaped domain [IPR025304]", "AMP-binding enzyme, C-terminal domain [IPR025110]", "AMP-dependent synthetase/ligase [IPR000873]", "AMPK, C-terminal adenylate sensor domain [IPR032270]", "AP complex, mu/sigma subunit [IPR022775]", "AP-2 complex subunit mu, N-terminal [IPR043532]", "AP-3 complex subunit beta 1, serine-rich domain [IPR029394]", "AP-3 complex subunit beta, C-terminal domain [IPR029390]", "AP-3 complex subunit delta domain, metazoa [IPR010474]", "AP180 N-terminal homology (ANTH) domain [IPR011417]", "APC10/DOC domain [IPR004939]", "ARHGEF1-like, PH domain [IPR041020]", "ARHGEF2, PH domain [IPR037806]", "ARID DNA-binding domain [IPR001606]", "ARMET, C-terminal [IPR019345]", "ARMET, N-terminal [IPR045332]", "ASCH domain [IPR007374]", "ATP synthase, F1 complex, alpha subunit nucleotide-binding domain [IPR033732]", "ATP synthase, alpha subunit, C-terminal [IPR000793]", "ATP-citrate lyase/succinyl-CoA ligase [IPR005811]", "ATP-citrate synthase, citrate-binding domain [IPR032263]", "ATP-cone domain [IPR005144]", "ATP-dependent DNA helicase RecQ, zinc-binding domain [IPR032284]", "ATP-dependent RNA helicase Ski2, C-terminal [IPR012961]", "ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain [IPR044728]", "ATP-grasp fold [IPR011761]", "ATP-grasp fold, succinyl-CoA synthetase-type [IPR013650]", "ATP-sulfurylase PUA-like domain [IPR025980]", "ATP:guanido phosphotransferase, N-terminal [IPR022413]", "ATP:guanido phosphotransferase, catalytic domain [IPR022414]", "ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]", "ATPase, AAA-type, core [IPR003959]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain [IPR004100]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain [IPR000194]", "ATPase, V1 complex, subunit H, C-terminal [IPR011987]", "ATPase, dynein-related, AAA domain [IPR011704]", "ATPsynthase alpha/beta subunit, N-terminal extension [IPR031686]", "AWS domain [IPR006560]", "Abscisic acid G-protein coupled receptor-like domain [IPR025969]", "Acetyl-CoA carboxylase [IPR034733]", "Acetyl-CoA carboxylase, central domain [IPR013537]", "Acetyl-coA carboxylase zinc finger domain [IPR041010]", "Acetyl-coenzyme A carboxyltransferase, C-terminal [IPR011763]", "Acetyl-coenzyme A carboxyltransferase, N-terminal [IPR011762]", "Acid ceramidase, N-terminal [IPR029130]", "Acinus, RNA recognition motif [IPR034257]", "Aconitase A, swivel domain [IPR044137]", "Aconitase A/isopropylmalate dehydratase small subunit, swivel domain [IPR000573]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain [IPR001030]", "Actin-depolymerising factor homology domain [IPR002108]", "Activating signal cointegrator 1 complex subunit 2, CUE domain [IPR041800]", "Activator of Hsp90 ATPase, N-terminal [IPR015310]", "Acyl transferase [IPR014043]", "Acyl-CoA dehydrogenase family member 10/11, N-terminal [IPR041726]", "Acyl-CoA dehydrogenase/oxidase C-terminal [IPR009075]", "Acyl-CoA dehydrogenase/oxidase, N-terminal [IPR013786]", "Acyl-CoA oxidase, C-terminal [IPR002655]", "Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091]", "Acyl-CoA-binding protein, ACBP [IPR000582]", "Acyl-coenzyme A oxidase, N-terminal [IPR029320]", "Acylamino-acid-releasing enzyme, N-terminal domain [IPR045550]", "Acylglycerol kinase, C-terminal [IPR045579]", "Acyltransferase, C-terminal domain [IPR032098]", "Adenomatous polyposis coli protein basic domain [IPR009234]", "Adenomatous polyposis coli, N-terminal dimerisation domain [IPR032038]", "Adenosine deaminase domain [IPR001365]", "Adenosine deaminase/editase [IPR002466]", "Adenylate cyclase-associated CAP, C-terminal [IPR013912]", "Adenylate cyclase-associated CAP, N-terminal [IPR013992]", "Adenylate kinase, active site lid domain [IPR007862]", "Adenylosuccinate lyase C-terminal [IPR019468]", "Afadin, cargo binding domain [IPR037977]", "Agenet-like domain [IPR008395]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal [IPR007886]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain [IPR007698]", "Alanyl-tRNA synthetase, class IIc, N-terminal [IPR018164]", "Alanyl-tRNA synthetase, class IIc, core domain [IPR018165]", "Alcohol dehydrogenase, N-terminal [IPR013154]", "Alcohol dehydrogenase-like, C-terminal [IPR013149]", "Aldehyde dehydrogenase domain [IPR015590]", "Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant [IPR000866]", "Alpha Spectrin, SH3 domain [IPR035825]", "Alpha crystallin/Hsp20 domain [IPR002068]", "Alpha galactosidase A, C-terminal beta-sandwich domain [IPR035373]", "Alpha-2-macroglobulin RAP, C-terminal [IPR010483]", "Alpha-2-macroglobulin RAP, domain 2 [IPR038001]", "Alpha-2-macroglobulin RAP, domain 3 [IPR037999]", "Alpha-2-macroglobulin receptor-associated protein, domain 1 [IPR009066]", "Alpha-D-phosphohexomutase, C-terminal [IPR005843]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain I [IPR005844]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain II [IPR005845]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain III [IPR005846]", "Alpha-L-fucosidase, C-terminal [IPR031919]", "Alpha-N-acetylglucosaminidase, C-terminal [IPR024732]", "Alpha-N-acetylglucosaminidase, N-terminal [IPR024240]", "Alpha-N-acetylglucosaminidase, tim-barrel domain [IPR024733]", "Alpha-dystroglycan N-terminal domain 2 [IPR041631]", "Alpha-glycerophosphate oxidase, C-terminal [IPR031656]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like [IPR027450]", "Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal [IPR024366]", "Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain [IPR024367]", "Alpha/beta hydrolase fold-1 [IPR000073]", "Amidase signature domain [IPR023631]", "Amidohydrolase-related [IPR006680]", "Amidophosphoribosyltransferase, N-terminal [IPR035584]", "Amine oxidase [IPR002937]", "Amino acid permease, N-terminal [IPR013612]", "Amino acid permease/ SLC12A domain [IPR004841]", "Amino acid transporter, transmembrane domain [IPR013057]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding [IPR045462]", "Aminoacyl-tRNA synthetase, class II (D/K/N) [IPR004364]", "Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) [IPR002314]", "Aminoacyl-tRNA synthetase, class II [IPR006195]", "Aminoacyl-tRNA synthetase, class Ia [IPR002300]", "Aminoglycoside phosphotransferase [IPR002575]", "Aminopeptidase N-like , N-terminal domain [IPR045357]", "Aminopeptidase P [IPR033740]", "Aminopeptidase P, N-terminal [IPR007865]", "Aminotransferase class V domain [IPR000192]", "Aminotransferase, class I/classII [IPR004839]", "Anaphase-promoting complex subunit 1, C-terminal [IPR041221]", "Anaphase-promoting complex subunit 2, C-terminal [IPR014786]", "Anaphase-promoting complex subunit 4 long domain [IPR024790]", "Anaphase-promoting complex subunit 4, WD40 domain [IPR024977]", "Anaphase-promoting complex subunit 5 domain [IPR026000]", "Ancestral coatomer element 1, Sec16/Sec31 [IPR024298]", "Angiomotin, C-terminal [IPR024646]", "Anillin homology domain [IPR012966]", "Anillin, N-terminal domain [IPR031970]", "Anillin, PH domain [IPR037840]", "Anion-transporting ATPase-like domain [IPR025723]", "Ankyrin repeat and LEM domain-containing protein 2, LEM domain [IPR035006]", "Ankyrin, UPA domain [IPR040745]", "Ankyrin-3, death domain [IPR037971]", "Anoctamin, dimerisation domain [IPR032394]", "Anticodon-binding [IPR004154]", "Anticodon-binding domain [IPR019181]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal [IPR006190]", "ApaG domain [IPR007474]", "Apoptosis-antagonizing transcription factor, C-terminal [IPR012617]", "Archaeal primase DnaG/twinkle, TOPRIM domain [IPR034154]", "Arf GTPase activating protein [IPR001164]", "Arfaptin homology (AH) domain [IPR010504]", "Arginyl tRNA synthetase N-terminal domain [IPR005148]", "Arginyl-tRNA synthetase, catalytic core domain [IPR035684]", "Ariadne domain [IPR045840]", "Armadillo repeat-containing domain [IPR006911]", "Aromatic amino acid beta-eliminating lyase/threonine aldolase [IPR001597]", "Asn/Gln amidotransferase [IPR018027]", "Asparagine synthase [IPR001962]", "Asparagine synthase, N-terminal domain [IPR033738]", "Aspartate/glutamate/uridylate kinase [IPR001048]", "Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain [IPR006131]", "Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding [IPR006132]", "Aspartic peptidase, DDI1-type [IPR019103]", "Aspartyl beta-hydroxylase/Triadin domain [IPR007943]", "Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic [IPR006075]", "Aspartyl/asparaginy/proline hydroxylase [IPR007803]", "Ataxin 2, SM domain [IPR025852]", "Ataxin-10 domain [IPR019156]", "Ataxin-2, C-terminal [IPR009818]", "Aurora kinase A [IPR030611]", "Aurora-A binding [IPR015128]", "Autophagy-related protein 13, N-terminal [IPR018731]", "Autophagy-related, C-terminal [IPR015412]", "B-block binding subunit of TFIIIC [IPR007309]", "B-box, C-terminal [IPR003649]", "B-box-type zinc finger [IPR000315]", "B3/B4 tRNA-binding domain [IPR005146]", "B30.2/SPRY domain [IPR001870]", "BAG domain [IPR003103]", "BAP29/BAP31, transmembrane domain [IPR040463]", "BAR domain [IPR004148]", "BAT2, N-terminal [IPR009738]", "BCL10, CARD domain [IPR042143]", "BCS1, N-terminal [IPR014851]", "BEACH domain [IPR000409]", "BEN domain [IPR018379]", "BING4, C-terminal domain [IPR012952]", "BOP1, N-terminal domain [IPR012953]", "BP28, C-terminal domain [IPR012954]", "BR140-related, PWWD domain [IPR035502]", "BRAP2, RNA recognition motif [IPR034932]", "BRCA1, serine-rich domain [IPR025994]", "BRCA1-associated 2 [IPR011422]", "BRCT domain [IPR001357]", "BRK domain [IPR006576]", "BRO1 domain [IPR004328]", "BRPF2, PHD domain [IPR042009]", "BRPF2, ePHD domain [IPR042004]", "BSD domain [IPR005607]", "BTB/Kelch-associated [IPR011705]", "BTB/POZ domain [IPR000210]", "BURAN domain [IPR045354]", "BZW1/2, W2 domain [IPR043510]", "Bacterial Ig-like, group 2 [IPR003343]", "Bacterial surface antigen (D15) [IPR000184]", "Band 3 cytoplasmic domain [IPR013769]", "Band 4.1 domain [IPR019749]", "Band 4.1, C-terminal [IPR008379]", "Band 7 domain [IPR001107]", "Band 7, C-terminal extension [IPR032435]", "Bap31/Bap29 cytoplasmic coiled-coil domain [IPR041672]", "Beta-Casp domain [IPR022712]", "Beta-adaptin appendage, C-terminal subdomain [IPR015151]", "Beta-catenin-interacting ICAT domain [IPR009428]", "Beta-catenin-like protein 1, N-terminal [IPR013180]", "Beta-galactosidase jelly roll domain [IPR025300]", "Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019]", "Beta-ketoacyl synthase, C-terminal [IPR014031]", "Beta-ketoacyl synthase, N-terminal [IPR014030]", "Beta-trefoil DNA-binding domain [IPR015350]", "Bicarbonate transporter, C-terminal [IPR011531]", "Bifunctional delta 1-pyrroline-5-carboxylate synthetase, glutamate-5-kinase domain [IPR041744]", "Biliverdin reductase, catalytic [IPR015249]", "Bin3-type S-adenosyl-L-methionine binding domain [IPR024160]", "Biotin carboxylase, C-terminal [IPR005482]", "Biotin carboxylase-like, N-terminal domain [IPR005481]", "Biotin carboxylation domain [IPR011764]", "Biotin protein ligase, C-terminal [IPR003142]", "Biotin-protein ligase, N-terminal [IPR019197]", "Biotin/lipoyl attachment [IPR000089]", "Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain [IPR004143]", "Bms1/Tsr1-type G domain [IPR030387]", "Borealin, N-terminal [IPR018851]", "Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal [IPR018955]", "Brdt, bromodomain, repeat I [IPR043508]", "Brdt, bromodomain, repeat II [IPR043509]", "Brix domain [IPR007109]", "Bromo adjacent homology (BAH) domain [IPR001025]", "Bromodomain [IPR001487]", "Bromodomain adjacent to zinc finger domain protein 1A, bromodomain [IPR037325]", "Bromodomain protein 4, C-terminal [IPR031354]", "Brr2, N-terminal helicase PWI domain [IPR041094]", "Bud22 domain [IPR015158]", "Butyrophylin-like, SPRY domain [IPR003879]", "C-CAP/cofactor C-like domain [IPR017901]", "C-terminal associated domain of TOPRIM [IPR031660]", "C-type lectin-like [IPR001304]", "C2 DOCK-type domain [IPR027007]", "C2 domain [IPR000008]", "C2 phosphatidylinositol 3-kinase-type domain [IPR002420]", "C2CD5, C2 domain [IPR037785]", "C4-type zinc-finger of DNA polymerase delta [IPR025687]", "CAAX prenyl protease 1, N-terminal [IPR032456]", "CALCOCO1/2, zinc finger UBZ1-type [IPR041641]", "CAP Gly-rich domain [IPR000938]", "CAPN2, penta-EF hand, calcium binding motif [IPR042736]", "CARD domain [IPR001315]", "CARG-binding factor, N-terminal [IPR012956]", "CARP motif [IPR006599]", "CASK, SH3 domain [IPR035473]", "CBS domain [IPR000644]", "CCAAT-binding factor [IPR005612]", "CCDC93, coiled-coil domain [IPR019159]", "CCR4-NOT transcription complex subunit 1, CAF1-binding domain [IPR032191]", "CCR4-NOT transcription complex subunit 1, HEAT repeat [IPR032194]", "CCR4-NOT transcription complex subunit 1, TTP binding domain [IPR032193]", "CCR4-NOT transcription complex subunit 1, domain 4 [IPR024557]", "CCR4-Not complex component, Not N-terminal domain [IPR007207]", "CCR4-Not complex component, Not1, C-terminal [IPR007196]", "CCZ1/INTU, second Longin domain [IPR043988]", "CCZ1/INTU/HPS4, third Longin domain [IPR043989]", "CCZ1/INTU/HSP4, first Longin domain [IPR043987]", "CD2-associated protein, first SH3 domain [IPR035775]", "CD2-associated protein, second SH3 domain [IPR035776]", "CD2-associated protein, third SH3 domain [IPR035777]", "CD209-like, C-type lectin-like domain [IPR033989]", "CD47 immunoglobulin-like [IPR013270]", "CD47 transmembrane [IPR013147]", "CD80-like, immunoglobulin C2-set [IPR013162]", "CDC48, N-terminal subdomain [IPR003338]", "CDC48, domain 2 [IPR004201]", "CDH1/2, SANT-Helical linker 1 [IPR040793]", "CELF1/2, RNA recognition motif 1 [IPR034196]", "CELF1/2, RNA recognition motif 2 [IPR034198]", "CELF1/2, RNA recognition motif 3 [IPR034199]", "CENP-T/Histone H4, histone fold [IPR035425]", "CENP-V/GFA domain [IPR006913]", "CEP170, C-terminal [IPR029300]", "CFA20 domain [IPR007714]", "CHCH [IPR010625]", "CHD subfamily II, SANT-like domain [IPR009462]", "CHD, C-terminal 2 [IPR012957]", "CHD, N-terminal [IPR012958]", "CHIP, N-terminal tetratricopeptide repeat domain [IPR041312]", "CHIP/LubX , U box domain [IPR045202]", "CHORD domain [IPR007051]", "CID domain [IPR006569]", "CIDE-N domain [IPR003508]", "CKK domain [IPR014797]", "CLASP N-terminal domain [IPR024395]", "CLU central domain [IPR033646]", "CLU domain [IPR025697]", "CNNM, transmembrane domain [IPR002550]", "COMM domain [IPR017920]", "COMMD1 N-terminal domain [IPR033776]", "COP9 signalosome complex subunit 4, helix turn helix domain [IPR041406]", "COP9 signalosome complex subunit 7, helix I [IPR041481]", "COS domain [IPR017903]", "CP2 transcription factor [IPR007604]", "CPH domain [IPR021097]", "CPL domain [IPR012959]", "CPSF2, metallo-hydrolase domain [IPR035639]", "CPSF7, RNA recognition motif [IPR034773]", "CRAL-TRIO lipid binding domain [IPR001251]", "CRIB domain [IPR000095]", "CRK, C-terminal SH3 domain [IPR035458]", "CRK, N-terminal SH3 domain [IPR035457]", "CS domain [IPR007052]", "CSK-like, SH2 domain [IPR035027]", "CSN8/PSMD8/EIF3K [IPR033464]", "CTLH, C-terminal LisH motif [IPR006595]", "CTP synthase GATase domain [IPR033828]", "CTP synthase, N-terminal [IPR017456]", "CUB domain [IPR000859]", "CYRIA/CYRIB, Rac1 binding domain [IPR009828]", "CYTH domain [IPR023577]", "Cadherin prodomain [IPR014868]", "Cadherin, cytoplasmic domain [IPR000233]", "Cadherin-like [IPR002126]", "Calcineurin-like phosphoesterase domain, ApaH type [IPR004843]", "Calcineurin-like phosphoesterase domain, lpxH-type [IPR024654]", "Calcium binding and coiled-coil domain-like [IPR012852]", "Calcium uniporter protein, C-terminal [IPR006769]", "Calcium/calmodulin-dependent protein kinase II, association-domain [IPR013543]", "Calcyclin-binding Protein, CS domain [IPR037893]", "Calmodulin-regulated spectrin-associated protein, CH domain [IPR022613]", "Calpain subdomain III [IPR033883]", "Calponin homology domain [IPR001715]", "Caprin-1 dimerization domain [IPR041637]", "Carbamoyl-phosphate synthase large subunit, CPSase domain [IPR005483]", "Carbamoyl-phosphate synthase small subunit, GATase1 domain [IPR035686]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain [IPR002474]", "Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain [IPR005479]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain [IPR005480]", "Carbohydrate kinase PfkB [IPR011611]", "Carboxylase, conserved domain [IPR003379]", "Carboxypeptidase D, carboxypeptidase-like domain 2 [IPR034224]", "Carboxypeptidase D, carboxypeptidase-like domain 3 [IPR033848]", "Carnitine O-palmitoyltransferase, N-terminal [IPR032476]", "Casein kinase substrate, phosphoprotein PP28 [IPR019380]", "Caspase recruitment domain [IPR031964]", "Cathepsin C [IPR039412]", "Cathepsin C exclusion [IPR014882]", "Cation-transporting P-type ATPase, C-terminal [IPR006068]", "Cation-transporting P-type ATPase, N-terminal [IPR004014]", "Cationic amino acid transporter, C-terminal [IPR029485]", "Cdc23 [IPR007192]", "Cdc37, C-terminal [IPR013873]", "Cdc37, Hsp90 binding [IPR013874]", "Cdc37, N-terminal domain [IPR013855]", "Cell division control protein 73, C-terminal [IPR031336]", "Cellular tumor antigen p53, transactivation domain 2 [IPR040926]", "Centrosomal CEP44 domain [IPR029157]", "Centrosomal protein of 290kDa, coiled-coil region [IPR032321]", "Centrosomin, N-terminal motif 1 [IPR012943]", "Chaperone DnaJ, C-terminal [IPR002939]", "Chitinase II [IPR011583]", "Choline/carnitine acyltransferase domain [IPR039551]", "Choloylglycine hydrolase/NAAA C-terminal [IPR029132]", "Chromatin assembly factor 1 subunit B, C-terminal domain [IPR029129]", "Chromatin assembly factor 1 subunit p150, C-terminal [IPR029105]", "Chromatin assembly factor 1 subunit p150, N-terminal [IPR029091]", "Chromatin target of PRMT1 protein, C-terminal [IPR025715]", "Chromo domain [IPR023780]", "Chromo domain subgroup [IPR017984]", "Chromo shadow domain [IPR008251]", "Chromo/chromo shadow domain [IPR000953]", "Chromosome passenger complex (CPC) protein INCENP N-terminal [IPR022006]", "Chromosome segregation protein Spc25, C-terminal [IPR013255]", "Circularly permuted (CP)-type guanine nucleotide-binding (G) domain [IPR030378]", "Class I myosin tail homology domain [IPR010926]", "Class I myosin, motor domain [IPR036072]", "Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain [IPR041715]", "Class II PurE [IPR033626]", "Class II aldolase/adducin N-terminal [IPR001303]", "Class VI myosin, motor domain [IPR036114]", "Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain [IPR003164]", "Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain [IPR008152]", "Clathrin, heavy chain, linker, core motif [IPR015348]", "Clathrin/coatomer adaptor, adaptin-like, N-terminal [IPR002553]", "Cleavage and polyadenylation specificity factor 2, C-terminal [IPR025069]", "Cleavage stimulation factor subunit 1, dimerisation domain [IPR032028]", "Cleavage stimulation factor subunit 2, hinge domain [IPR025742]", "Cleavage/polyadenylation specificity factor, A subunit, C-terminal [IPR004871]", "Cleavage/polyadenylation specificity factor, A subunit, N-terminal [IPR018846]", "Clp ATPase, C-terminal [IPR019489]", "Clustered mitochondria protein, N-terminal [IPR028275]", "Cns1/TTC4, wheel domain [IPR044059]", "CoA-binding [IPR003781]", "Coagulation factor 5/8 C-terminal domain [IPR000421]", "Coatomer beta subunit, C-terminal [IPR011710]", "Coatomer beta subunit, appendage platform domain [IPR029446]", "Coatomer subunit gamma, C-terminal [IPR032154]", "Coatomer, WD associated region [IPR006692]", "Coatomer, alpha subunit, C-terminal [IPR010714]", "Coatomer, gamma subunit, appendage, Ig-like subdomain [IPR013040]", "Cobalamin (vitamin B12)-binding domain [IPR006158]", "Cobalamin (vitamin B12)-binding module, cap domain [IPR003759]", "Cobalamin adenosyltransferase-like [IPR016030]", "Coilin, N-terminal domain [IPR031722]", "Cold shock domain [IPR011129]", "Cold-shock (CSD) domain [IPR019844]", "Cold-shock protein, DNA-binding [IPR002059]", "Complex 1 LYR protein domain [IPR008011]", "Condensin complex subunit 1, C-terminal [IPR032682]", "Condensin complex subunit 1, N-terminal [IPR024324]", "Conserved oligomeric Golgi complex, subunit 4 [IPR013167]", "Cop9 signalosome subunit 5 C-terminal domain [IPR040961]", "Copine, C-terminal [IPR010734]", "Copine, C2B domain [IPR037768]", "Core histone macro-H2A, macro domain [IPR035796]", "Cortactin, SH3 domain [IPR035716]", "Cortactin-binding protein-2, N-terminal [IPR019131]", "Creatinase, N-terminal [IPR000587]", "Cro/C1-type helix-turn-helix domain [IPR001387]", "Cullin homology domain [IPR016158]", "Cullin protein, neddylation domain [IPR019559]", "Cullin, N-terminal [IPR001373]", "Cwf19-like protein, C-terminal domain-2 [IPR006767]", "Cwf19-like, C-terminal domain-1 [IPR006768]", "Cyclic nucleotide-binding domain [IPR000595]", "Cyclin, C-terminal domain [IPR004367]", "Cyclin, N-terminal [IPR006671]", "Cyclin-like [IPR013763]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain [IPR002130]", "Cystatin domain [IPR000010]", "Cysteine-rich flanking region, C-terminal [IPR000483]", "Cystine knot, C-terminal [IPR006207]", "Cytidyltransferase-like domain [IPR004821]", "Cytochrome C oxidase subunit II, transmembrane domain [IPR011759]", "Cytochrome b-c1 complex subunit Rieske, transmembrane domain [IPR004192]", "Cytochrome b5-like heme/steroid binding domain [IPR001199]", "Cytochrome c oxidase assembly factor 3, mitochondrial, coiled-coil domain [IPR018628]", "Cytochrome c oxidase subunit 2, C-terminal [IPR034210]", "Cytochrome c oxidase subunit II-like C-terminal [IPR002429]", "Cytochrome c oxidase, subunit II [IPR014222]", "Cytoplasmic activation/proliferation-associated protein-1 C term [IPR022070]", "Cytoskeleton-associated protein 2, C-terminal [IPR029197]", "D-3-phosphoglycerate dehydrogenase, ASB domain [IPR045626]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain [IPR006140]", "D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain [IPR006139]", "DALR anticodon binding [IPR008909]", "DAMP1, SANT/Myb-like domain [IPR032563]", "DAZ-associated protein 1, RNA recognition motif 1 [IPR034134]", "DAZ-associated protein 1, RNA recognition motif 2 [IPR034131]", "DBC1/CARP1 catalytically inactive NUDIX hydrolase domain [IPR025954]", "DBINO domain [IPR020838]", "DBP10, C-terminal [IPR012541]", "DDE superfamily endonuclease domain [IPR004875]", "DDHD domain [IPR004177]", "DDT domain [IPR018501]", "DDX18/Has1, DEAD-box helicase domain [IPR044773]", "DDX41, DEAD-box helicase domain [IPR044113]", "DDX47/Rrp3, DEAD-box helicase domain [IPR044765]", "DDX52/Rok1, DEAD-box helicase domain [IPR044764]", "DEAD box protein 17, ATP-binding domain [IPR046330]", "DEAD/DEAH box helicase domain [IPR011545]", "DEK, C-terminal [IPR014876]", "DEUBAD domain [IPR044867]", "DFDF domain [IPR025762]", "DG-type SEA domain [IPR030398]", "DHHA1 domain [IPR003156]", "DHX15, DEXH-box helicase domain [IPR044756]", "DHX8/ Prp22, DEXH-box helicase domain [IPR044762]", "DHX9, DEXH-box helicase domain [IPR044447]", "DHX9, first double-stranded RNA binding domain [IPR044445]", "DHX9, second double-stranded RNA binding domain [IPR044446]", "DJ-1/PfpI [IPR002818]", "DMAP1-binding domain [IPR010506]", "DML1/Misato, tubulin domain [IPR029209]", "DNA (cytosine-5)-methyltransferase 1, replication foci domain [IPR022702]", "DNA damage inducible protein 1 ubiquitin-like domain [IPR033882]", "DNA fragmentation factor 45kDa, middle domain [IPR015121]", "DNA helicase, DnaB-like, C-terminal [IPR007694]", "DNA ligase 3, BRCT domain [IPR031916]", "DNA ligase, ATP-dependent, C-terminal [IPR012309]", "DNA ligase, ATP-dependent, N-terminal [IPR012308]", "DNA ligase, ATP-dependent, central [IPR012310]", "DNA methyltransferase 1-associated 1 [IPR008468]", "DNA mismatch repair protein MutS, C-terminal [IPR000432]", "DNA mismatch repair protein MutS, clamp [IPR007861]", "DNA mismatch repair protein MutS, connector domain [IPR007860]", "DNA mismatch repair protein MutS, core [IPR007696]", "DNA mismatch repair protein MutS-like, N-terminal [IPR007695]", "DNA mitochondrial polymerase, exonuclease domain [IPR041336]", "DNA polymerase alpha catalytic subunit, N-terminal domain [IPR024647]", "DNA polymerase alpha catalytic subunit, catalytic domain [IPR045846]", "DNA polymerase alpha/delta/epsilon, subunit B [IPR007185]", "DNA polymerase delta subunit 2, C-terminal domain [IPR041863]", "DNA polymerase delta subunit, OB-fold domain [IPR040663]", "DNA polymerase epsilon subunit B, N-terminal [IPR024639]", "DNA polymerase epsilon, catalytic subunit A, C-terminal [IPR013697]", "DNA repair Nbs1, C-terminal [IPR013908]", "DNA replication complex GINS protein SLD5, C-terminal [IPR031633]", "DNA replication factor Dna2, N-terminal [IPR014808]", "DNA replication factor RFC1, C-terminal [IPR013725]", "DNA topoisomerase 2, TOPRIM domain [IPR034157]", "DNA topoisomerase I, DNA binding, eukaryotic-type [IPR008336]", "DNA topoisomerase I, catalytic core, eukaryotic-type [IPR013500]", "DNA topoisomerase I, eukaryotic-type [IPR013499]", "DNA topoisomerase, type IIA, domain A [IPR002205]", "DNA topoisomerase, type IIA, subunit B, domain 2 [IPR013506]", "DNA-dependent protein kinase catalytic subunit, CC3 [IPR012582]", "DNA-dependent protein kinase catalytic subunit, CC5 [IPR045581]", "DNA-dependent protein kinase catalytic subunit, catalytic domain [IPR037706]", "DNA-directed DNA polymerase, family A, palm domain [IPR001098]", "DNA-directed DNA polymerase, family B, exonuclease domain [IPR006133]", "DNA-directed DNA polymerase, family B, multifunctional domain [IPR006134]", "DNA-directed RNA polymerase I subunit RPA2, domain 4 [IPR009674]", "DNA-directed RNA polymerase III subunit RPC1, C-terminal [IPR035698]", "DNA-directed RNA polymerase III subunit RPC1, N-terminal [IPR035697]", "DNA-directed RNA polymerase III subunit RPC5, C-terminal [IPR045576]", "DNA-directed RNA polymerase, N-terminal [IPR029262]", "DNA-directed RNA polymerase, RpoA/D/Rpb3-type [IPR011263]", "DNA-directed RNA polymerase, insert domain [IPR011262]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120]", "DNA-repair protein Xrcc1, N-terminal [IPR002706]", "DNA/RNA non-specific endonuclease [IPR001604]", "DNA/RNA-binding domain, Est1-type [IPR018834]", "DNA/RNA-binding protein Kin17, WH-like domain [IPR019447]", "DNA2/NAM7 helicase, helicase domain [IPR041677]", "DNA2/NAM7 helicase-like, C-terminal [IPR041679]", "DOCKER domain [IPR027357]", "DPF1-3, N-terminal domain [IPR025750]", "DSBA-like thioredoxin domain [IPR001853]", "DTHCT [IPR012542]", "DUS-like, FMN-binding domain [IPR035587]", "DUS2, double-stranded RNA binding domain [IPR044463]", "DWNN domain [IPR014891]", "DZF domain [IPR006561]", "Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791]", "Dbl homology (DH) domain [IPR000219]", "Death domain [IPR000488]", "Dedicator of cytokinesis C, C2 domain [IPR037808]", "Dedicator of cytokinesis C/D, N-terminal [IPR021816]", "Dedicator of cytokinesis, N-terminal domain [IPR032376]", "Dehydrogenase, E1 component [IPR001017]", "Deoxynucleoside kinase domain [IPR031314]", "Desmoplakin, SH3 domain [IPR041615]", "Desmoplakin, spectrin-like domain [IPR041573]", "Deubiquitinating enzyme MINDY-3/4, conserved domain [IPR025257]", "DhaK domain [IPR004006]", "DhaL domain [IPR004007]", "Diacylglycerol kinase, catalytic domain [IPR001206]", "Diacylglycerol/phorbol-ester binding [IPR020454]", "Diaphanous autoregulatory (DAD) domain [IPR014767]", "Dicer dimerisation domain [IPR005034]", "Dicer, double-stranded RNA-binding domain [IPR044441]", "Dihydrofolate reductase domain [IPR001796]", "Dihydroorotate dehydrogenase domain [IPR005720]", "Dilute domain [IPR002710]", "Dipeptidyl peptidase 8 /9 ,N-terminal [IPR045785]", "Dipeptidylpeptidase IV, N-terminal domain [IPR002469]", "Dis3-like cold-shock domain 2 [IPR041505]", "Disks large homologue 1, N-terminal PEST domain [IPR019590]", "Disulphide isomerase [IPR005788]", "DnaJ domain [IPR001623]", "DnaJ homolog subfamily C member 16, TRX domain [IPR043361]", "DnaJ homologue subfamily C, GRV2/DNAJC13, N-terminal domain [IPR045802]", "DnaJ-like protein C11, C-terminal [IPR024586]", "Dolichyldiphosphatase, PAP2 domain [IPR039667]", "Domain of unknown function DM14 [IPR006608]", "Domain of unknown function DUF1087 [IPR009463]", "Domain of unknown function DUF1115 [IPR010541]", "Domain of unknown function DUF155 [IPR003734]", "Domain of unknown function DUF1605 [IPR011709]", "Domain of unknown function DUF1731 [IPR013549]", "Domain of unknown function DUF1747 [IPR013719]", "Domain of unknown function DUF1899 [IPR015048]", "Domain of unknown function DUF3350 [IPR021785]", "Domain of unknown function DUF3385, target of rapamycin protein [IPR024585]", "Domain of unknown function DUF3456 [IPR021852]", "Domain of unknown function DUF3480 [IPR022557]", "Domain of unknown function DUF3517 [IPR021905]", "Domain of unknown function DUF3677 [IPR022145]", "Domain of unknown function DUF3699 [IPR022168]", "Domain of unknown function DUF382 [IPR007180]", "Domain of unknown function DUF4149 [IPR025423]", "Domain of unknown function DUF4171 [IPR025228]", "Domain of unknown function DUF4208 [IPR025260]", "Domain of unknown function DUF4217 [IPR025313]", "Domain of unknown function DUF4749 [IPR031847]", "Domain of unknown function DUF5600 [IPR040990]", "Domain of unknown function DUF5604 [IPR040880]", "Domain of unknown function DUF5921 [IPR045803]", "Domain of unknown function DUF625 [IPR006887]", "Double-stranded RNA-binding domain [IPR014720]", "Down-regulated-in-metastasis protein [IPR011430]", "Drebrin-like protein, SH3 domain [IPR035717]", "Dual specificity phosphatase, catalytic domain [IPR000340]", "Dual specificity protein phosphatase domain [IPR020422]", "Dynamin GTPase effector [IPR003130]", "Dynamin stalk domain [IPR000375]", "Dynamin, GTPase domain [IPR001401]", "Dynamin, N-terminal [IPR045063]", "Dynamin-like GTPase OPA1, C-terminal [IPR045817]", "Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]", "Dynein associated protein [IPR022157]", "Dynein heavy chain AAA lid domain [IPR041658]", "Dynein heavy chain region D6 P-loop domain [IPR004273]", "Dynein heavy chain, AAA 5 extension domain [IPR041466]", "Dynein heavy chain, AAA module D4 [IPR024317]", "Dynein heavy chain, ATP-binding dynein motor region [IPR035706]", "Dynein heavy chain, C-terminal domain [IPR041228]", "Dynein heavy chain, coiled coil stalk [IPR024743]", "Dynein heavy chain, hydrolytic ATP-binding dynein motor region [IPR035699]", "Dynein heavy chain, linker [IPR013602]", "Dynein heavy chain, tail [IPR013594]", "Dyskerin-like [IPR012960]", "Dystroglycan, C-terminal [IPR008465]", "Dystroglycan-type cadherin-like [IPR006644]", "E1A-binding protein p400, N-terminal [IPR031575]", "E2 binding [IPR014929]", "E3 ligase, CCCH-type zinc finger [IPR041367]", "E3 ubiquitin ligase EDD, ubiquitin-associated domain [IPR024725]", "E3 ubiquitin ligase UBR4, C-terminal [IPR025704]", "E3 ubiquitin ligase, domain of unknown function DUF908 [IPR010309]", "E3 ubiquitin ligase, domain of unknown function DUF913 [IPR010314]", "E3 ubiquitin-protein ligase UBR4, N-terminal [IPR045841]", "EB-1 binding [IPR009232]", "EB1, C-terminal [IPR004953]", "EBP50, C-terminal [IPR015098]", "ECSIT, C-terminal domain [IPR029342]", "EF hand associated, type-1 [IPR013566]", "EF hand associated, type-2 [IPR013567]", "EF-hand domain [IPR002048]", "EF-hand domain, type 1 [IPR015153]", "EF-hand domain, type 2 [IPR015154]", "EF-hand, Ca insensitive [IPR014837]", "EFG, domain V [IPR035649]", "EGF-like calcium-binding domain [IPR001881]", "EGF-like domain [IPR000742]", "EGF-like domain, extracellular [IPR013111]", "EH domain [IPR000261]", "EH domain-containing protein, N-terminal [IPR031692]", "EIF2AK2, first double-stranded RNA binding domain [IPR044452]", "EIF2AK2, second double-stranded RNA binding domain [IPR044453]", "ELK domain [IPR005539]", "ELM2 domain [IPR000949]", "ELMO domain [IPR006816]", "ELMO, armadillo-like helical domain [IPR024574]", "ELYS, beta-propeller domain [IPR032040]", "ELYS-like domain [IPR025151]", "ENTH domain [IPR013809]", "ER membrane protein complex subunit 1, C-terminal [IPR011678]", "ER membrane protein complex subunit 7, beta-sandwich domain [IPR019008]", "ERAP1-like C-terminal domain [IPR024571]", "ERCC3/RAD25/XPB helicase, C-terminal domain [IPR032438]", "ERM family, FERM domain C-lobe [IPR041789]", "ERV/ALR sulfhydryl oxidase domain [IPR017905]", "ERdj5, C-terminal thioredoxin domain [IPR035674]", "ERdj5, first thioredoxin domain [IPR035673]", "ERp29, N-terminal [IPR012883]", "EVE domain [IPR002740]", "EWS, RNA recognition motif [IPR034869]", "EXPERA domain [IPR033118]", "Electron transfer flavoprotein, alpha subunit, C-terminal [IPR014731]", "Electron transfer flavoprotein, alpha subunit, N-terminal [IPR033947]", "Electron transfer flavoprotein, alpha/beta-subunit, N-terminal [IPR014730]", "Electron transfer flavoprotein, beta subunit, N-terminal [IPR033948]", "Elongation Factor G, domain II [IPR041095]", "Elongation factor 1 beta central acidic region, eukaryote [IPR018940]", "Elongation factor 1B gamma, C-terminal [IPR001662]", "Elongation factor 4, domain IV [IPR035654]", "Elongation factor EFG, domain V-like [IPR000640]", "Elongation factor G, domain III [IPR009022]", "Elongation factor Tu (EF-Tu), GTP-binding domain [IPR041709]", "Elongation factor Tu, domain 2 [IPR033720]", "Elp3/MiaB/NifB [IPR006638]", "Emerin, LEM domain [IPR034989]", "Endonuclease/exonuclease/phosphatase [IPR005135]", "Endophilin B2, SH3 domain [IPR035640]", "Endophilin-A, SH3 domain [IPR035824]", "Endophilin-B1, BAR domain [IPR035695]", "Endoplasmic reticulum resident protein 29, C-terminal [IPR011679]", "Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]", "Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]", "Enhancer of mRNA-decapping protein 4, WD40 repeat region [IPR032401]", "Enhancer of polycomb-like, N-terminal [IPR019542]", "Enolase, C-terminal TIM barrel domain [IPR020810]", "Enolase, N-terminal [IPR020811]", "Enoyl-CoA hydratase/isomerase domain [IPR045004]", "Ephrin receptor ligand binding domain [IPR001090]", "Ephrin receptor, transmembrane domain [IPR027936]", "Ephrin type-A receptor 7, ligand binding domain [IPR034283]", "Era-type guanine nucleotide-binding (G) domain [IPR030388]", "Eukaryotic Ribosomal Protein L27, KOW domain [IPR041991]", "Eukaryotic glycogen debranching enzyme, N-terminal domain [IPR029436]", "Eukaryotic translation initiation factor 2D, SUI1 domain [IPR039759]", "Eukaryotic translation initiation factor 3 subunit E, N-terminal [IPR019010]", "Eukaryotic translation initiation factor 3 subunit G, N-terminal [IPR024675]", "Exocyst complex component EXOC2/Sec5, N-terminal domain [IPR039481]", "Exonuclease 1-like, PIN-like domain [IPR044752]", "Exonuclease, RNase T/DNA polymerase III [IPR013520]", "Exonuclease-1, H3TH domain [IPR037315]", "Exoribonuclease, phosphorolytic domain 1 [IPR001247]", "Exoribonuclease, phosphorolytic domain 2 [IPR015847]", "Exosome complex component CSL4, C-terminal [IPR019495]", "Exosome complex component, N-terminal domain [IPR025721]", "Exosome complex exonuclease RRP44, S1 domain [IPR033770]", "Exosome-associated factor Rrp6, N-terminal [IPR012588]", "Exportin-1, C-terminal [IPR014877]", "Exportin-1/Importin-beta-like [IPR013598]", "Exportin-2, C-terminal [IPR005043]", "Exportin-2, central domain [IPR013713]", "Exportin-5, C-terminal domain [IPR045478]", "Exportin-T, C-terminal domain [IPR045546]", "Extended PHD (ePHD) domain [IPR034732]", "Extended synaptotagmin, C-terminal C2 domain [IPR037752]", "Extended synaptotagmin, C2A domain [IPR037733]", "Extended synaptotagmin, C2B domain [IPR037749]", "Extracellular Endonuclease, subunit A [IPR020821]", "F-BAR domain [IPR031160]", "F-box domain [IPR001810]", "FACT complex subunit POB3-like, N-terminal PH domain [IPR035417]", "FACT complex subunit Spt16 domain [IPR013953]", "FACT complex subunit Spt16, N-terminal lobe domain [IPR029148]", "FACT complex subunit Spt16, peptidase M24-like domain [IPR033825]", "FAD dependent oxidoreductase [IPR006076]", "FAD linked oxidase, N-terminal [IPR006094]", "FAD-binding domain, PCMH-type [IPR016166]", "FAD-binding domain, ferredoxin reductase-type [IPR017927]", "FAD-dependent oxidoreductase 2, FAD binding domain [IPR003953]", "FAD-linked oxidase, C-terminal [IPR004113]", "FAD/NAD(P)-binding domain [IPR023753]", "FAF1, UBA-like domain [IPR044541]", "FAM3C (ILEI) domain [IPR039475]", "FANCI helical domain 1 [IPR029310]", "FANCI helical domain 2 [IPR029312]", "FANCI solenoid 1 cap [IPR029305]", "FANCI solenoid 1 domain [IPR029308]", "FANCI solenoid 2 domain [IPR029315]", "FANCI solenoid 3 domain [IPR029313]", "FANCI solenoid 4 domain [IPR029314]", "FARP1/FARP2/FRMD7, FERM domain C-lobe [IPR041788]", "FAS-associated factor 1-like, UBX domain [IPR033043]", "FAST kinase leucine-rich [IPR010622]", "FAST kinase-like protein, subdomain 2 [IPR013579]", "FATC domain [IPR003152]", "FCH domain [IPR001060]", "FCP1 homology domain [IPR004274]", "FDF domain [IPR019050]", "FERM adjacent (FA) [IPR014847]", "FERM central domain [IPR019748]", "FERM domain [IPR000299]", "FERM, C-terminal PH-like domain [IPR018980]", "FERM, N-terminal [IPR018979]", "FF domain [IPR002713]", "FFD box [IPR025761]", "FGFR1 oncogene partner (FOP), N-terminal dimerisation domain [IPR018993]", "FHOD1, N-terminal GTPase-binding domain [IPR041387]", "FIST, C-domain [IPR019494]", "FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]", "FKBP12-rapamycin binding domain [IPR009076]", "FKBP3, basic tilted helix bundle domain [IPR041200]", "FYVE zinc finger [IPR000306]", "Far upstream element-binding protein, C-terminal [IPR015096]", "Far11/STRP, C-terminal [IPR021819]", "Far11/STRP, N-terminal [IPR012486]", "Fascin domain [IPR022768]", "Fatty acid desaturase domain [IPR005804]", "Fatty acid hydroxylase [IPR006694]", "Fatty acyl-CoA reductase, C-terminal [IPR033640]", "Fatty acyl-coenzyme A reductase, NAD-binding domain [IPR013120]", "Fcf2 pre-rRNA processing, C-terminal [IPR014810]", "Ferritin-like diiron domain [IPR009040]", "Ferritin/DPS protein domain [IPR008331]", "Ferrochelatase, C-terminal [IPR033644]", "Ferrochelatase, N-terminal [IPR033659]", "Fibronectin type II domain [IPR000562]", "Fibronectin type III [IPR003961]", "First polo-box domain [IPR033701]", "Flavodoxin-like [IPR001094]", "Flavodoxin/nitric oxide synthase [IPR008254]", "Flavoprotein pyridine nucleotide cytochrome reductase [IPR001709]", "Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain [IPR008333]", "Follistatin-like, N-terminal [IPR003645]", "Fork head domain [IPR001766]", "Forkhead-associated (FHA) domain [IPR000253]", "Formin, FH2 domain [IPR015425]", "Formin, FH3 domain [IPR010472]", "Formin, GTPase-binding domain [IPR010473]", "Formin-binding protein 1, F-BAR domain [IPR037449]", "Formyl transferase, N-terminal [IPR002376]", "Fragile X-related 1 protein, C-terminal core [IPR022034]", "Fragile X-related 1 protein, C-terminal region 1 [IPR032172]", "Fragile X-related 1 protein, C-terminal region 3 [IPR032177]", "Freud, C2 domain [IPR037772]", "Fumarase C, C-terminal [IPR018951]", "Fumarate lyase, N-terminal [IPR022761]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal [IPR015939]", "Fumarylacetoacetase, N-terminal [IPR015377]", "Fumarylacetoacetase-like, C-terminal [IPR011234]", "Fungal lipase-like domain [IPR002921]", "Fxr1, tudor domain [IPR041560]", "Fzo/mitofusin HR2 domain [IPR006884]", "G-patch domain [IPR000467]", "G-patch domain and KOW motifs-containing protein, KOW 1 [IPR041993]", "G-patch domain and KOW motifs-containing protein, KOW 2 [IPR041994]", "G-protein, beta subunit [IPR001632]", "G3BP1, RNA recognition motif [IPR034374]", "G3BP2, RNA recognition motif [IPR034376]", "GAD domain [IPR029351]", "GAR domain [IPR003108]", "GAT domain [IPR004152]", "GB1/RHD3-type guanine nucleotide-binding (G) domain [IPR030386]", "GCC2, Rab binding domain [IPR032023]", "GCF, C-terminal [IPR022783]", "GHMP kinase N-terminal domain [IPR006204]", "GHMP kinase, C-terminal domain [IPR013750]", "GINS complex protein Sld5, alpha-helical domain [IPR038749]", "GINS subunit, domain A [IPR021151]", "GMP phosphodiesterase, delta subunit [IPR008015]", "GMP synthase, C-terminal [IPR001674]", "GMP synthase, glutamine amidotransferase [IPR004739]", "GMP synthetase ATP pyrophosphatase domain [IPR025777]", "GNAT domain [IPR000182]", "GOLD domain [IPR009038]", "GPAT/DHAPAT, acyltransferase domain [IPR041728]", "GPI ethanolamine phosphate transferase 2, C-terminal [IPR045687]", "GPI ethanolamine phosphate transferase 2, N-terminal [IPR037674]", "GPR domain [IPR000965]", "GRAM domain [IPR004182]", "GRASP-type PDZ domain [IPR024958]", "GRB2, C-terminal SH3 domain [IPR035643]", "GRB2, N-terminal SH3 domain [IPR035641]", "GRIP domain [IPR000237]", "GRSF-1, RNA recognition motif 1 [IPR034425]", "GRSF-1, RNA recognition motif 2 [IPR034424]", "GRSF-1, RNA recognition motif 3 [IPR034426]", "GTP binding domain [IPR006073]", "GTP binding protein 1-like, GTP-binding domain [IPR035531]", "GTP binding protein, second domain [IPR031662]", "GTP-binding protein LepA, C-terminal [IPR013842]", "GTP-binding protein TrmE, N-terminal [IPR018948]", "GTPase effector domain [IPR020850]", "GUCT [IPR012562]", "GYF domain 2 [IPR025640]", "GYF domain [IPR003169]", "Galactokinase, N-terminal domain [IPR019539]", "Galactose mutarotase, N-terminal barrel [IPR031727]", "Galectin, carbohydrate recognition domain [IPR001079]", "Gamma tubulin complex component protein, N-terminal [IPR041470]", "Gamma tubulin complex component, C-terminal [IPR040457]", "Gamma-adaptin ear (GAE) domain [IPR008153]", "Gamma-butyrobetaine hydroxylase-like, N-terminal [IPR010376]", "Gamma-glutamyl cyclotransferase-like [IPR013024]", "Gcp-like domain [IPR000905]", "Gelsolin-like domain [IPR007123]", "Gfo/Idh/MocA-like oxidoreductase, N-terminal [IPR000683]", "GlmS/AgaS, SIS domain 1 [IPR035466]", "GlmS/FrlB, SIS domain 2 [IPR035490]", "Glucosamine/galactosamine-6-phosphate isomerase [IPR006148]", "Glucose-6-phosphate dehydrogenase, C-terminal [IPR022675]", "Glucose-6-phosphate dehydrogenase, NAD-binding [IPR022674]", "Glucosidase 2 subunit beta-like [IPR036607]", "Glucosidase II beta subunit, N-terminal [IPR028146]", "Glucosyltransferase 24, catalytic domain [IPR040497]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal [IPR006096]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain [IPR006097]", "Glutaminase, EF-hand domain [IPR041541]", "Glutamine amidotransferase [IPR017926]", "Glutamine amidotransferase type 2 domain [IPR017932]", "Glutamine-Leucine-Glutamine, QLQ [IPR014978]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2 [IPR007638]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal [IPR007639]", "Glutamyl-tRNA synthetase [IPR033910]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain [IPR020059]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain [IPR020058]", "Glutaredoxin [IPR002109]", "Glutaredoxin, PICOT-like [IPR033658]", "Glutathione S-transferase, C-terminal [IPR004046]", "Glutathione S-transferase, C-terminal-like [IPR010987]", "Glutathione S-transferase, N-terminal [IPR004045]", "Glutathione S-transferases, class Zeta , C-terminal [IPR034330]", "Glutathione S-transferases, class Zeta , N-terminal [IPR034333]", "Glutathione synthase, substrate-binding domain [IPR004887]", "Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain [IPR020828]", "Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain [IPR020829]", "Glycerol-3-phosphate acyltransferase-like, C-terminal domain [IPR045520]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal [IPR006109]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal [IPR011128]", "Glycerophosphodiester phosphodiesterase domain [IPR030395]", "Glycogen debranching enzyme, C-terminal [IPR032790]", "Glycogen debranching enzyme, central domain [IPR032788]", "Glycogen debranching enzyme, glucanotransferase domain [IPR032792]", "Glycogen synthase kinase 3, catalytic domain [IPR039192]", "Glycolipid transfer protein domain [IPR014830]", "Glycoside hydrolase 35, catalytic domain [IPR031330]", "Glycoside hydrolase family 18, catalytic domain [IPR001223]", "Glycoside hydrolase family 2, catalytic domain [IPR006103]", "Glycoside hydrolase family 20, catalytic domain [IPR015883]", "Glycoside hydrolase family 31, N-terminal domain [IPR025887]", "Glycoside hydrolase family 38, N-terminal domain [IPR000602]", "Glycoside hydrolase family 38, central domain [IPR015341]", "Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich [IPR006102]", "Glycosyl hydrolase family 30, TIM-barrel domain [IPR033453]", "Glycosyl hydrolase family 30, beta sandwich domain [IPR033452]", "Glycosyl hydrolase family 38, C-terminal [IPR011682]", "Glycosyl hydrolase family 63, C-terminal [IPR031335]", "Glycosyl hydrolase family 63, N-terminal [IPR031631]", "Glycosyl hydrolase, family 13, catalytic domain [IPR006047]", "Glycosyl hydrolases family 2, sugar binding domain [IPR006104]", "Glycosyl transferase CAP10 domain [IPR006598]", "Glycosyl transferase, family 1 [IPR001296]", "Glycosyltransferase 2-like [IPR001173]", "Glycyl-tRNA synthetase-like core domain [IPR033731]", "Glyoxalase domain-containing protein 4, C-terminal [IPR043194]", "Glyoxalase/fosfomycin resistance/dioxygenase domain [IPR004360]", "Golgi pH regulator, conserved domain [IPR022535]", "Golgin subfamily A, conserved domain [IPR043976]", "Growth hormone-inducible transmembrane protein [IPR035871]", "Guanine nucleotide exchange factor, N-terminal [IPR032691]", "Guanine nucleotide-binding protein-like 3, N-terminal domain [IPR014813]", "Guanylate kinase-like domain [IPR008144]", "Guanylate kinase/L-type calcium channel beta subunit [IPR008145]", "Guanylate-binding protein, N-terminal [IPR015894]", "Guanylate-binding protein/Atlastin, C-terminal [IPR003191]", "HAD-superfamily hydrolase, subfamily IIID [IPR011943]", "HBS1-like protein, N-terminal [IPR015033]", "HD domain [IPR006674]", "HD/PDEase domain [IPR003607]", "HDGF-related, PWWP domain [IPR035496]", "HECT domain [IPR000569]", "HELLS, N-terminal [IPR044753]", "HELP [IPR005108]", "HHH domain 9 [IPR041692]", "HIRAN domain [IPR014905]", "HIT-like domain [IPR011146]", "HORMA domain [IPR003511]", "HR1 rho-binding domain [IPR011072]", "HRDC domain [IPR002121]", "HSPA4, nucleotide-binding domain [IPR042052]", "HSPA4L, nucleotide-binding domain [IPR042708]", "HSPH1, nucleotide-binding domain [IPR042053]", "HTH CenpB-type DNA-binding domain [IPR006600]", "HTTM [IPR011020]", "HUWE1, UBA domain [IPR041918]", "Heat shock 70kDa protein 14, nucleotide-binding domain [IPR042049]", "Heat shock chaperonin-binding [IPR006636]", "Heat shock protein DnaJ, cysteine-rich domain [IPR001305]", "Heat shock protein Hsp90, N-terminal [IPR020575]", "Heat shock protein beta-1, ACD domain [IPR037876]", "Heavy metal-associated domain, HMA [IPR006121]", "Heavy metal-associated domain, copper ion-binding [IPR006122]", "Helicase XPB/Ssl2, N-terminal domain [IPR032830]", "Helicase domain [IPR007807]", "Helicase superfamily 1/2, ATP-binding domain [IPR014001]", "Helicase, C-terminal [IPR001650]", "Helicase-associated domain [IPR007502]", "Helicase/SANT-associated domain [IPR014012]", "Helicase/UvrB, N-terminal [IPR006935]", "Helix-hairpin-helix DNA-binding motif, class 1 [IPR003583]", "Helix-turn-helix DNA-binding domain of Spt6 [IPR028088]", "Hemimethylated DNA-binding domain [IPR011722]", "Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain [IPR024641]", "Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 1 [IPR034544]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 2 [IPR034548]", "Heterogeneous nuclear ribonucleoprotein R, RNA recognition motif 2 [IPR034411]", "Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]", "Hexokinase, C-terminal [IPR022673]", "Hexokinase, N-terminal [IPR022672]", "High mobility group box domain 5 [IPR029215]", "High mobility group box domain [IPR009071]", "Histidine kinase domain [IPR005467]", "Histidine kinase/HSP90-like ATPase [IPR003594]", "Histidyl-anticodon-binding [IPR033656]", "Histone H2A, C-terminal domain [IPR032454]", "Histone H2A/H2B/H3 [IPR007125]", "Histone acetyl transferase HAT1 N-terminal [IPR019467]", "Histone acetyltransferase domain, MYST-type [IPR002717]", "Histone deacetylase domain [IPR023801]", "Histone deacetylase interacting domain [IPR013194]", "Histone methyltransferase, Tudor domain 1 [IPR041291]", "Histone methyltransferase, Tudor domain 2 [IPR041292]", "Histone-arginine methyltransferase CARM1, N-terminal [IPR020989]", "Histone-binding protein RBBP4, N-terminal [IPR022052]", "HnRNP M, nuclear localisation signal [IPR024666]", "Homeobox domain [IPR001356]", "Homocysteine-binding domain [IPR003726]", "Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120]", "HuR, RNA recognition motif 2 [IPR034996]", "Hyaluronan/mRNA-binding protein [IPR006861]", "Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain [IPR013746]", "Hydroxymethylglutaryl-coenzyme A synthase, N-terminal [IPR013528]", "I/LWEQ domain [IPR002558]", "IBR domain [IPR002867]", "IF2a, S1-like domain [IPR044126]", "IGF2BP1, RNA recognition motif 1 [IPR034837]", "IGF2BP1, RNA recognition motif 2 [IPR034842]", "IGF2BP2, RNA recognition motif 1 [IPR034843]", "IGF2BP3, RNA recognition motif 2 [IPR034844]", "ILEI/PANDER domain [IPR039477]", "IMD/I-BAR domain [IPR013606]", "IMP dehydrogenase/GMP reductase [IPR001093]", "IPS1, CARD domain [IPR042144]", "IPT domain [IPR002909]", "IRG-type guanine nucleotide-binding (G) domain [IPR030385]", "IRS-type PTB domain [IPR002404]", "IRSp53, SH3 domain [IPR035594]", "ISWI, HAND domain [IPR015194]", "Ima1, N-terminal domain [IPR018617]", "Immunoglobulin C1-set [IPR003597]", "Immunoglobulin I-set [IPR013098]", "Immunoglobulin V-set domain [IPR013106]", "Immunoglobulin [IPR013151]", "Immunoglobulin subtype 2 [IPR003598]", "Immunoglobulin subtype [IPR003599]", "Immunoglobulin-like domain [IPR007110]", "Importin-alpha, importin-beta-binding domain [IPR002652]", "Importin-beta, N-terminal domain [IPR001494]", "Initiation factor eIF-4 gamma, MA3 [IPR003891]", "Inner centromere protein, ARK-binding domain [IPR005635]", "Inositol polyphosphate 5-phosphatase, clathrin binding domain [IPR031995]", "Inositol polyphosphate-related phosphatase [IPR000300]", "Int12, PHD finger [IPR039054]", "Integrator complex subunit 11, MBL-fold [IPR041897]", "Integrator complex subunit 14, C-terminal [IPR045814]", "Integrator complex subunit 3, N-terminal [IPR019333]", "Integrin alpha-2 [IPR013649]", "Integrin beta N-terminal [IPR033760]", "Integrin beta subunit, VWA domain [IPR002369]", "Integrin beta subunit, cytoplasmic domain [IPR014836]", "Integrin beta subunit, tail [IPR012896]", "Integrin beta, epidermal growth factor-like domain 1 [IPR040622]", "Interferon regulatory factor 2-binding protein 1 & 2, zinc finger [IPR022750]", "Intermediate filament head, DNA-binding domain [IPR006821]", "Intermediate filament, rod domain [IPR039008]", "Intracellular hyaluronan-binding protein 4, N-terminal domain [IPR032381]", "Intron-binding protein aquarius, N-terminal [IPR032174]", "Ion transporter-like, CBS domain [IPR044751]", "Iron sulphur domain-containing, mitoNEET, N-terminal [IPR019610]", "Iron-binding zinc finger, CDGSH type [IPR018967]", "Isochorismatase-like [IPR000868]", "Isoleucyl tRNA synthetase type 1, anticodon-binding domain [IPR033708]", "Isoleucyl tRNA synthetase type 2, anticodon-binding domain [IPR033709]", "Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain [IPR044861]", "Isopropylmalate dehydrogenase-like domain [IPR024084]", "JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]", "JNK-interacting protein, leucine zipper II [IPR032486]", "JNK/Rab-associated protein-1, N-terminal [IPR019143]", "JmjC domain [IPR003347]", "JmjN domain [IPR003349]", "Jumonji, helical domain [IPR041070]", "K Homology domain [IPR004087]", "K Homology domain, type 1 [IPR004088]", "K Homology domain, type 2 [IPR004044]", "KASH domain [IPR012315]", "KHDRBS, Qua1 domain [IPR032571]", "KN17, SH3-like C-terminal domain [IPR041330]", "KOW [IPR005824]", "Kin17, KOW domain [IPR041995]", "Kinase associated domain 1 (KA1) [IPR001772]", "Kindlin-2, N-terminal [IPR040790]", "Kindlin/fermitin, PH domain [IPR037837]", "Kinesin motor domain [IPR001752]", "Kinesin-associated [IPR032405]", "Kinesin-associated microtubule-binding domain [IPR025901]", "Kinesin-like KIF1-type [IPR022140]", "Kinesin-like [IPR022164]", "Kinesin-like protein Kif23, Arf6-interacting domain [IPR032384]", "Kri1-like, C-terminal [IPR024626]", "Krr1, KH1 domain [IPR041174]", "Ku, C-terminal [IPR014893]", "Ku70/Ku80 C-terminal arm [IPR005160]", "Ku70/Ku80 beta-barrel domain [IPR006164]", "Ku70/Ku80, N-terminal alpha/beta [IPR005161]", "L27 domain [IPR004172]", "L27 domain, C-terminal [IPR014775]", "L27-1 [IPR015143]", "LAIKA domain [IPR045353]", "LARP4, RNA recognition motif [IPR034903]", "LARP5, RNA recognition motif [IPR034900]", "LARP7, RNA recognition motif 1 [IPR034887]", "LARP7, RNA recognition motif 2 [IPR034910]", "LEM domain [IPR003887]", "LEM-like domain [IPR013146]", "LETM1, ribosome-binding domain [IPR033122]", "LETM1-like [IPR011685]", "LIM interaction domain [IPR041363]", "LIS1 homology motif [IPR006594]", "LRRC8, pannexin-like TM region [IPR021040]", "LSM domain, eukaryotic/archaea-type [IPR001163]", "LSM-interacting domain [IPR008669]", "LYRM2, LYR domain [IPR045293]", "La protein, xRRM domain [IPR014886]", "La-related protein 7, La domain [IPR034946]", "La-type HTH domain [IPR006630]", "Lactate/malate dehydrogenase, C-terminal [IPR022383]", "Lactate/malate dehydrogenase, N-terminal [IPR001236]", "Lamin tail domain [IPR001322]", "Lamin-B receptor of TUDOR domain [IPR019023]", "Lamina-associated polypeptide 2 alpha, C-terminal [IPR021623]", "Laminin G domain [IPR001791]", "Laminin IV type B [IPR013015]", "Laminin, N-terminal [IPR008211]", "Laminin-type EGF domain [IPR002049]", "Large proline-rich protein BAG6 [IPR021925]", "Lasp1, SH3 domain [IPR035630]", "Legume-like lectin [IPR005052]", "Lens epithelium-derived growth factor, integrase-binding domain [IPR021567]", "Lethal giant larvae homologue 2 [IPR013577]", "Leucine zipper, homeobox-associated [IPR003106]", "Leucine-rich repeat N-terminal domain [IPR000372]", "Leukocyte surface antigen CD47, IgV [IPR037805]", "Linker histone H1/H5, domain H15 [IPR005818]", "Liprin-alpha, SAM domain repeat 1 [IPR037620]", "Liprin-alpha, SAM domain repeat 2 [IPR037621]", "Liprin-alpha, SAM domain repeat 3 [IPR037622]", "Lon, substrate-binding domain [IPR003111]", "Longin domain [IPR010908]", "Lsm14-like, N-terminal [IPR025609]", "Lsm16, N-terminal [IPR034107]", "LsmAD domain [IPR009604]", "Lunapark domain [IPR019273]", "Lysine-specific demethylase-like domain [IPR013637]", "Lysine-tRNA ligase, class II, N-terminal [IPR044136]", "Lysophosphatidylcholine acyltransferase LPCAT1-like [IPR045252]", "Lysyl-tRNA synthetase, class II, C-terminal [IPR018149]", "M60-like domain, N-terminal [IPR035423]", "MAGE homology domain [IPR002190]", "MAM domain [IPR000998]", "MAN1, RNA recognition motif [IPR034394]", "MANSC domain [IPR013980]", "MATH/TRAF domain [IPR002083]", "MCM N-terminal domain [IPR027925]", "MCM OB domain [IPR033762]", "MCM domain [IPR001208]", "MCM, AAA-lid domain [IPR041562]", "MD-2-related lipid-recognition domain [IPR003172]", "MDM2-binding protein, N-terminal domain [IPR029421]", "MDM2-binding protein, central domain [IPR029420]", "MDN2-binding protein, C-terminal domain [IPR029418]", "MEF-2, RNA recognition motif 1 [IPR034630]", "MEF-2, RNA recognition motif 3 [IPR034631]", "MENTAL domain [IPR019498]", "MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]", "MHC class I, alpha chain, C-terminal [IPR010579]", "MHC class I-like antigen recognition-like [IPR011161]", "MIA2, SH3 domain [IPR035555]", "MIF4G-like, type 1 [IPR015172]", "MIF4G-like, type 2 [IPR015174]", "MIF4G-like, type 3 [IPR003890]", "MIRO domain [IPR020860]", "MIT domain [IPR007330]", "MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding [IPR021043]", "MMS19, C-terminal [IPR024687]", "MMS19, N-terminal [IPR029240]", "MOSC, N-terminal beta barrel [IPR005303]", "MPN domain [IPR037518]", "MPP1, SH3 domain [IPR035475]", "MPP2, SH3 domain [IPR035602]", "MPP6, SH3 domain [IPR035603]", "MRG domain [IPR026541]", "MRH domain [IPR044865]", "MRPL44, double-stranded RNA binding domain [IPR044444]", "MST4, kinase domain [IPR035056]", "MYST, zinc finger domain [IPR040706]", "Mab-21 domain [IPR024810]", "Macro domain [IPR002589]", "Mad3/Bub1 homology region 1 [IPR013212]", "Major facilitator superfamily domain [IPR020846]", "Major sperm protein (MSP) domain [IPR000535]", "Malectin domain [IPR021720]", "Malic enzyme, N-terminal domain [IPR012301]", "Malic enzyme, NAD-binding [IPR012302]", "Man1/Src1, C-terminal [IPR018996]", "Manganese/iron superoxide dismutase, C-terminal [IPR019832]", "Manganese/iron superoxide dismutase, N-terminal [IPR019831]", "MaoC-like dehydratase domain [IPR002539]", "Marvel domain [IPR008253]", "Matrin-3, RNA recognition motif 1 [IPR034928]", "Matrin-3, RNA recognition motif 2 [IPR034930]", "Matrin/U1-C, C2H2-type zinc finger [IPR000690]", "Matrin/U1-C-like, C2H2-type zinc finger [IPR003604]", "Mcm6, C-terminal winged-helix domain [IPR041024]", "Mediator complex, subunit Med1 [IPR019680]", "Membrane insertase YidC/Oxa1, C-terminal [IPR028055]", "Metallo-beta-lactamase [IPR001279]", "Metastasis-associated protein MTA1, R1 domain [IPR035170]", "Metaxin, glutathione S-transferase domain [IPR033468]", "Methionine synthase, B12-binding domain [IPR033706]", "Methionine--tRNA ligase, N-terminal [IPR041598]", "Methioninyl-tRNA synthetase core domain [IPR033911]", "Methionyl-tRNA synthetase, anticodon-binding domain [IPR041872]", "Methionyl/Leucyl tRNA synthetase [IPR015413]", "Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding [IPR013155]", "Methyl-CpG DNA binding [IPR001739]", "Methyl-CpG binding protein 2/3, C-terminal domain [IPR025884]", "Methyl-CpG-binding domain protein 2/3, p55-binding region [IPR032343]", "Methylglyoxal synthase-like domain [IPR011607]", "Methylmalonyl-CoA mutase, C-terminal [IPR006159]", "Methylmalonyl-CoA mutase, alpha chain, catalytic [IPR006098]", "Methylmalonyl-CoA mutase, alpha/beta chain, catalytic [IPR006099]", "Methylthiotransferase, N-terminal [IPR013848]", "Methyltransferase domain 25 [IPR041698]", "Methyltransferase domain [IPR025714]", "Methyltransferase type 11 [IPR013216]", "Methyltransferase type 12 [IPR013217]", "Mff-like domain [IPR039433]", "Mib-herc2 [IPR010606]", "Micro-fibrillar-associated protein 1, C-terminal [IPR009730]", "Midasin AAA lid domain 5 [IPR041190]", "Midasin, AAA lid domain 7 [IPR040848]", "Midline-1, COS domain [IPR040859]", "Misato Segment II tubulin-like domain [IPR019605]", "Mitochondrial apoptosis-inducing factor, C-terminal domain [IPR029324]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs [IPR034884]", "Mitochondrial degradasome RNA helicase subunit, C-terminal domain [IPR022192]", "Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564]", "Mitochondrial ribosomal protein L46 NUDIX [IPR033650]", "MnmE, helical domain [IPR025867]", "MoaB/Mog domain [IPR001453]", "Modifier of rudimentary, Modr [IPR009851]", "Molybdenum cofactor sulfurase, C-terminal [IPR005302]", "Molybdopterin oxidoreductase [IPR006656]", "Molybdopterin oxidoreductase, 4Fe-4S domain [IPR006963]", "Morc, S5 domain 2-like [IPR041006]", "Mre11 nuclease, N-terminal metallophosphatase domain [IPR041796]", "Mre11, DNA-binding [IPR007281]", "Mst1 SARAH domain [IPR024205]", "Mu homology domain [IPR028565]", "Mu2, C-terminal domain [IPR043512]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal [IPR031717]", "Multiple myeloma tumor-associated protein 2-like, N-terminal [IPR019315]", "Multiprotein bridging factor 1, N-terminal [IPR013729]", "Mvd1, C-terminal [IPR041431]", "Myb domain [IPR017930]", "Myo-inositol-1-phosphate synthase, GAPDH-like [IPR013021]", "Myosin VI, cargo binding domain [IPR032412]", "Myosin head, motor domain [IPR001609]", "Myosin phosphatase-RhoA interacting protein, PH domain [IPR039597]", "Myosin tail [IPR002928]", "Myosin, N-terminal, SH3-like [IPR004009]", "Myosin-binding domain [IPR026859]", "Myristoyl-CoA:protein N-myristoyltransferase, C-terminal [IPR022677]", "Myristoyl-CoA:protein N-myristoyltransferase, N-terminal [IPR022676]", "N-CoR, GPS2-interacting domain [IPR031557]", "N-acetylgalactosaminyltransferase [IPR045885]", "N-acetylneuraminic acid synthase, N-terminal [IPR013132]", "N-terminal extension of GAT domain [IPR041198]", "NAD(P) binding domain of glutamate dehydrogenase [IPR033922]", "NAD(P) transhydrogenase, alpha subunit, C-terminal [IPR024605]", "NAD(P)-binding domain [IPR016040]", "NAD-dependent epimerase/dehydratase [IPR001509]", "NAD/GMP synthase [IPR022310]", "NADH dehydrogenase subunit 5, C-terminal [IPR010934]", "NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal [IPR001516]", "NADH-quinone oxidoreductase, chain G, C-terminal [IPR015405]", "NADH-quinone oxidoreductase, subunit D [IPR001135]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain [IPR011538]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain [IPR019575]", "NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit [IPR001750]", "NADH:ubiquinone oxidoreductase, 30kDa subunit [IPR001268]", "NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding [IPR019574]", "NADH:ubiquinone oxidoreductase-like, 20kDa subunit [IPR006137]", "NADP transhydrogenase beta-like domain [IPR034300]", "NADP-dependent oxidoreductase domain [IPR023210]", "NDUFB9, LYR domain [IPR045292]", "NECAP, PHear domain [IPR012466]", "NEDD8 ultimate buster 1, ubiquitin-like domain [IPR041207]", "NEMO, Zinc finger [IPR034735]", "NET domain [IPR027353]", "NF-kappa-B essential modulator NEMO, CC2-LZ domain [IPR032419]", "NF-kappa-B essential modulator NEMO, N-terminal [IPR021063]", "NF-kappaB-repression factor, R3H domain [IPR034071]", "NFACT protein, C-terminal [IPR021846]", "NFACT, RNA-binding domain [IPR008532]", "NFRKB winged helix-like domain [IPR025220]", "NGN domain [IPR005100]", "NGN domain, eukaryotic [IPR039385]", "NHL2, NHL repeat domain [IPR045302]", "NIF system FeS cluster assembly, NifU, N-terminal [IPR002871]", "NIPSNAP [IPR012577]", "NLE [IPR012972]", "NOG, C-terminal [IPR012973]", "NOG1, N-terminal helical domain [IPR041623]", "NOP5, N-terminal [IPR012974]", "NOPS [IPR012975]", "NOSIC [IPR012976]", "NOT2/NOT3/NOT5, C-terminal [IPR007282]", "NP60, PWWP domain [IPR035501]", "NPL4, zinc-binding putative [IPR007716]", "NSD, Cys-His rich domain [IPR041306]", "NUC153 [IPR012580]", "NUC205 domain [IPR012584]", "NUDIX hydrolase [IPR020476]", "NUDIX hydrolase domain [IPR000086]", "NVL2, nucleolin binding domain [IPR031996]", "Nascent polypeptide-associated complex NAC domain [IPR002715]", "Negative elongation factor E, RNA recognition motif [IPR034637]", "Neurabin-1/2, PDZ domain [IPR040645]", "Neurobeachin-like, DUF1088 [IPR010508]", "Neurobeachin/BDCP, DUF4704 [IPR031570]", "Neuroblastoma-amplified sequence, N-terminal [IPR029145]", "Neuropilin, C-terminal [IPR022579]", "Nibrin, second BRCT domain [IPR032429]", "Nicastrin, small lobe [IPR041084]", "Nicotinamide phosphoribosyltransferase, N-terminal domain [IPR041529]", "Nicotinate/nicotinamide phosphoribosyltransferase [IPR041525]", "Niemann-Pick C1, N-terminal [IPR032190]", "Nin one binding (NOB1) Zn-ribbon-like [IPR014881]", "Nischarin, PX domain [IPR037904]", "Nitric oxide synthase-interacting protein, zinc-finger [IPR031790]", "Non-canonical purine NTP phosphatase/PRRC1 [IPR026533]", "Nop domain [IPR002687]", "Nop2p [IPR011023]", "Novel protein kinase C delta, catalytic domain [IPR034667]", "Npc2 like, ML domain [IPR033916]", "Nrap protein domain 1 [IPR035082]", "Nrap protein, domain 2 [IPR035367]", "Nrap protein, domain 3 [IPR035368]", "Nrap protein, domain 4 [IPR035369]", "Nrap protein, domain 5 [IPR035370]", "Nrap protein, domain 6 [IPR035371]", "Nuclear RNA export factor Tap, RNA-binding domain [IPR015245]", "Nuclear condensin complex subunit 3, C-terminal domain [IPR025977]", "Nuclear migration protein nudC [IPR032572]", "Nuclear pore complex protein Nup214, phenylalanine-glycine (FG) domain [IPR041553]", "Nuclear pore complex, NUP2/50/61 [IPR015007]", "Nuclear pore localisation protein NPL4, C-terminal [IPR007717]", "Nuclear pore localisation protein Npl4, ubiquitin-like domain [IPR024682]", "Nuclear protein 96 [IPR021967]", "Nuclear speckle splicing regulatory protein 1, N-terminal [IPR018612]", "Nuclear transport factor 2 domain [IPR002075]", "Nuclear transport factor 2, eukaryote [IPR018222]", "Nuclear-interacting partner of ALK/Rsm1-like [IPR013909]", "Nucleolar GTP-binding protein 1, Rossman-fold domain [IPR010674]", "Nucleolar GTP-binding protein 2, N-terminal domain [IPR012971]", "Nucleolar complex-associated protein 3, N-terminal [IPR011501]", "Nucleolar pre-ribosomal-associated protein 1, C-terminal domain [IPR032436]", "Nucleolar pre-ribosomal-associated protein 1, N-terminal [IPR021714]", "Nucleolar protein 7, C-terminal [IPR012579]", "Nucleolar protein 8, RNA recognition motif [IPR034138]", "Nucleolin, RNA recognition motif 1 [IPR034230]", "Nucleolin, RNA recognition motif 2 [IPR034233]", "Nucleolin, RNA recognition motif 3 [IPR034234]", "Nucleolin, RNA recognition motif 4 [IPR034235]", "Nucleophosmin, C-terminal [IPR032569]", "Nucleoplasmin core domain [IPR024057]", "Nucleoporin Nup153, N-terminal [IPR013913]", "Nucleoporin Nup188, N-terminal [IPR018864]", "Nucleoporin Nup54, alpha-helical domain [IPR025712]", "Nucleoporin, NSP1-like, C-terminal [IPR007758]", "Nucleoporin, Nup133/Nup155-like, C-terminal [IPR007187]", "Nucleoporin, Nup133/Nup155-like, N-terminal [IPR014908]", "Nucleoprotein TPR/MLP1 [IPR012929]", "Nucleoredoxin, redox inactive TRX-like domain b' [IPR041861]", "Nucleoside diphosphate kinase-like domain [IPR034907]", "Nucleoside phosphorylase domain [IPR000845]", "Nucleotide exchange factor Fes1 [IPR013918]", "Nucleotidyl transferase domain [IPR005835]", "NudC N-terminal domain [IPR025934]", "NudC domain-containing protein 2, p23 domain [IPR037902]", "NudC domain-containing protein 3, p23 domain [IPR037905]", "NuoE domain [IPR042128]", "Nup358/RanBP2 E3 ligase domain [IPR022011]", "Nup54, C-terminal interacting domain [IPR040985]", "NusG, N-terminal [IPR006645]", "O-GlcNAc transferase, C-terminal [IPR029489]", "OB-fold nucleic acid binding domain, AA-tRNA synthetase-type [IPR004365]", "OBG-type guanine nucleotide-binding (G) domain [IPR031167]", "OCRE domain [IPR041591]", "OCRL1, PH domain [IPR037787]", "OCRL1/INPP5B, INPP5c domain [IPR037793]", "OTU domain [IPR003323]", "Occludin homology domain [IPR010844]", "Orc1-like, AAA ATPase domain [IPR041664]", "Origin recognition complex subunit 3, N-terminal [IPR045667]", "Origin recognition complex subunit 3, insertion domain [IPR045663]", "Origin recognition complex subunit 3, winged helix C-terminal [IPR040855]", "Orotate phosphoribosyl transferase domain [IPR004467]", "Orotidine 5'-phosphate decarboxylase domain [IPR001754]", "Ovarian carcinoma immunoreactive antigen domain [IPR009764]", "Oxidoreductase FAD/NAD(P)-binding [IPR001433]", "Oxidoreductase, N-terminal domain [IPR041694]", "Oxoglutarate/iron-dependent dioxygenase [IPR005123]", "P-type ATPase, haloacid dehalogenase domain [IPR044492]", "P-type trefoil domain [IPR000519]", "PA domain [IPR003137]", "PABP, RNA recognition motif 2 [IPR045305]", "PACSIN1/PACSIN2, SH3 domain [IPR035743]", "PACSIN2, F-BAR domain [IPR037453]", "PADR1 domain [IPR012982]", "PAP/25A-associated [IPR002058]", "PARN, R3H domain [IPR034042]", "PAZ domain [IPR003100]", "PB1 domain [IPR000270]", "PD-(D/E)XK endonuclease-like domain, AddAB-type [IPR038726]", "PDIP3, RNA recognition motif [IPR034784]", "PDZ domain 6 [IPR041489]", "PDZ domain [IPR001478]", "PDZ-associated domain of NMDA receptors [IPR019583]", "PET domain [IPR010442]", "PET testin [IPR033724]", "PH-BEACH domain [IPR023362]", "PHR [IPR012983]", "PI31 proteasome regulator, N-terminal [IPR021625]", "PI3K p85 subunit, C-terminal SH2 domain [IPR035020]", "PI3K p85 subunit, N-terminal SH2 domain [IPR035022]", "PI3K regulatory subunit p85-related , inter-SH2 domain [IPR032498]", "PI3K-C2-alpha, catalytic domain [IPR037705]", "PI4-kinase, N-terminal [IPR045495]", "PIH1, N-terminal [IPR012981]", "PIH1D1/2/3, CS-like domain [IPR041442]", "PIK-related kinase [IPR014009]", "PIK-related kinase, FAT [IPR003151]", "PIN domain [IPR002716]", "PITH domain [IPR010400]", "PKD domain [IPR000601]", "PKD/Chitinase domain [IPR022409]", "PLAA family ubiquitin binding domain [IPR015155]", "PLC-gamma, C-terminal SH2 domain [IPR035023]", "PLC-gamma, N-terminal SH2 domain [IPR035024]", "PLD-like domain [IPR032803]", "POLO box domain [IPR000959]", "POPLD domain [IPR012590]", "POTRA domain [IPR034746]", "PP5, C-terminal metallophosphatase domain [IPR041753]", "PPIL4-like, cyclophilin domain [IPR035538]", "PPM-type phosphatase domain [IPR001932]", "PPP domain [IPR013235]", "PRELI/MSF1 domain [IPR006797]", "PRKAA2, UBA-like autoinhibitory domain [IPR028783]", "PRKRA, first double-stranded RNA binding domain [IPR044465]", "PRKRA, second double-stranded RNA binding domain [IPR044466]", "PRKRA, third double-stranded RNA binding domain [IPR044467]", "PRMT5 arginine-N-methyltransferase [IPR035075]", "PRMT5, TIM barrel domain [IPR035247]", "PRMT5, oligomerisation domain [IPR035248]", "PRO8NT domain [IPR012591]", "PROCN domain [IPR012592]", "PROCT domain [IPR012984]", "PRP1 splicing factor, N-terminal [IPR010491]", "PRP8 domain IV core [IPR021983]", "PSF, NOPS domain [IPR034526]", "PSF, RNA recognition motif 1 [IPR034525]", "PSI domain [IPR016201]", "PSP, proline-rich [IPR006568]", "PSP1, RNA recognition motif 1 [IPR034522]", "PSP1, RNA recognition motif 2 [IPR034523]", "PTB/PI domain [IPR006020]", "PTBP1, RNA recognition motif 1 [IPR035000]", "PTBP1, RNA recognition motif 2-like [IPR021790]", "PTBP1, RNA recognition motif 3 [IPR035001]", "PTBP2, RNA recognition motif 1 [IPR035002]", "PTBP2, RNA recognition motif 3 [IPR034799]", "PTBP2, RNA recognition motif 4 [IPR034800]", "PUA domain [IPR002478]", "PUF60, RNA recognition motif 1 [IPR034209]", "PUF60, RNA recognition motif 2 [IPR034211]", "PUF60, RNA recognition motif 3 [IPR034212]", "PUL domain [IPR013535]", "PWI domain [IPR002483]", "PWWP domain [IPR000313]", "Paf1 complex subunit Cdc73, N-terminal domain [IPR032041]", "Palladin, C-terminal immunoglobulin-like domain [IPR033017]", "Palmitoyltransferase, DHHC domain [IPR001594]", "Patatin-like phospholipase domain [IPR002641]", "Pentacotripeptide-repeat region of PRORP [IPR033443]", "Pep3/Vps18/deep orange [IPR007810]", "Peptidase C12, C-terminal domain [IPR041507]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase [IPR001578]", "Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394]", "Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615]", "Peptidase C1A, papain C-terminal [IPR000668]", "Peptidase C2, calpain, catalytic domain [IPR001300]", "Peptidase C2, calpain, domain III [IPR022683]", "Peptidase C2, calpain, large subunit, domain III [IPR022682]", "Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal [IPR015211]", "Peptidase M1, membrane alanine aminopeptidase [IPR014782]", "Peptidase M13, C-terminal domain [IPR018497]", "Peptidase M13, N-terminal domain [IPR008753]", "Peptidase M14, carboxypeptidase A [IPR000834]", "Peptidase M16, C-terminal [IPR007863]", "Peptidase M16, N-terminal [IPR011765]", "Peptidase M16, middle/third domain [IPR032632]", "Peptidase M16C associated [IPR013578]", "Peptidase M17, leucyl aminopeptidase, C-terminal [IPR000819]", "Peptidase M17, leucyl aminopeptidase, N-terminal [IPR008283]", "Peptidase M20, dimerisation domain [IPR011650]", "Peptidase M24 [IPR000994]", "Peptidase M24, C-terminal domain [IPR032416]", "Peptidase M28 [IPR007484]", "Peptidase M3A/M3B catalytic domain [IPR001567]", "Peptidase M41 [IPR000642]", "Peptidase M41, FtsH extracellular [IPR011546]", "Peptidase M48 [IPR001915]", "Peptidase S16, Lon proteolytic domain [IPR008269]", "Peptidase S53, activation domain [IPR015366]", "Peptidase S54, rhomboid domain [IPR022764]", "Peptidase S59, nucleoporin [IPR007230]", "Peptidase S8/S53 domain [IPR000209]", "Peptidase S8A, tripeptidyl peptidase II [IPR022229]", "Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375]", "Peptidase S9A, N-terminal domain [IPR023302]", "Peptidase family M60 domain [IPR031161]", "Peptide chain release factor class I [IPR000352]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type [IPR000297]", "Pericentrin/AKAP-450 centrosomal targeting domain [IPR019528]", "Pericentriolar material 1 protein, C-terminal [IPR031446]", "Peripheral subunit-binding domain [IPR004167]", "Peroxiredoxin, C-terminal [IPR019479]", "Peroxisome biogenesis factor 1, N-terminal, alpha/beta [IPR015343]", "Peroxisome biogenesis factor 1, N-terminal, psi beta-barrel fold [IPR015342]", "Peroxisome membrane anchor protein Pex14p, N-terminal [IPR006785]", "PheRS DNA binding domain 2 [IPR040586]", "PheRS, DNA binding domain 1 [IPR040724]", "PheRS, DNA binding domain 3 [IPR040725]", "Phenylacetic acid degradation-related domain [IPR003736]", "Phenylalanine--tRNA ligase beta subunit, B1 domain [IPR040659]", "Phenylalanyl tRNA synthetase beta chain, core domain [IPR041616]", "Phenylalanyl-tRNA synthetase [IPR002319]", "Phosducin, thioredoxin-like domain [IPR024253]", "Phosphatidic acid phosphatase type 2/haloperoxidase [IPR000326]", "Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403]", "Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain [IPR000341]", "Phosphatidylinositol 3-kinase regulatory subunit beta, SH3 domain [IPR035586]", "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PX domain [IPR042133]", "Phosphatidylinositol-4-phosphate 5-kinase, core [IPR002498]", "Phosphatidylinositol-specific phospholipase C, X domain [IPR000909]", "Phosphoadenosine phosphosulphate reductase [IPR002500]", "Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain [IPR035077]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal [IPR035078]", "Phosphofructokinase domain [IPR000023]", "Phosphoglucose isomerase, SIS domain 1 [IPR035476]", "Phosphoglucose isomerase, SIS domain 2 [IPR035482]", "Phosphoinositide 3-kinase, accessory (PIK) domain [IPR001263]", "Phospholipase C, phosphatidylinositol-specific, Y domain [IPR001711]", "Phospholipase D-like domain [IPR025202]", "Phospholipase D/Transphosphatidylase [IPR001736]", "Phospholipase/carboxylesterase/thioesterase [IPR003140]", "Phospholipid/glycerol acyltransferase [IPR002123]", "Phosphopantetheine binding ACP domain [IPR009081]", "Phosphoribosylformylglycinamidine synthase, N-terminal [IPR040707]", "Phosphoribosylformylglycinamidine synthase, linker domain [IPR041609]", "Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain [IPR020561]", "Phosphoribosylglycinamide synthetase, C-domain [IPR020560]", "Phosphoribosylglycinamide synthetase, N-terminal [IPR020562]", "Phosphoribosyltransferase domain [IPR000836]", "Phosphoribulokinase/uridine kinase [IPR006083]", "Phosphorylated adapter RNA export protein, RNA-binding domain [IPR019385]", "Phosphotyrosine protein phosphatase I [IPR023485]", "Phox homology [IPR001683]", "Pinin/SDK [IPR006787]", "Pinin/SDK/MemA protein [IPR006786]", "Pirin, C-terminal domain [IPR008778]", "Pirin, N-terminal domain [IPR003829]", "Plasma membrane calcium transporting P-type ATPase, C-terminal [IPR022141]", "Pleckstrin homology domain 9 [IPR041681]", "Pleckstrin homology domain [IPR001849]", "Pleckstrin homology domain, spectrin-type [IPR001605]", "Plectin/S10, N-terminal [IPR005326]", "Plexin, TIG domain 1 [IPR041019]", "Plexin, cytoplasmic RasGAP domain [IPR013548]", "Plus-3 domain [IPR004343]", "Polo-like kinase 1, catalytic domain [IPR033702]", "Poly(A) polymerase, RNA-binding domain [IPR007010]", "Poly(A) polymerase, central domain [IPR007012]", "Poly(A)-specific ribonuclease, RNA-binding [IPR014789]", "Poly(ADP-ribose) polymerase, catalytic domain [IPR012317]", "Poly(ADP-ribose) polymerase, regulatory domain [IPR004102]", "Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004]", "Polyamine biosynthesis domain [IPR030374]", "Polycomb group protein, RNA binding region [IPR033763]", "Polycomb protein, VEFS-Box [IPR019135]", "Polyketide synthase, C-terminal extension [IPR032821]", "Polyketide synthase, beta-ketoacyl synthase domain [IPR020841]", "Polyketide synthase, dehydratase domain [IPR020807]", "Polyketide synthase, enoylreductase domain [IPR020843]", "Polyketide synthase, ketoreductase domain [IPR013968]", "Polyketide synthase, phosphopantetheine-binding domain [IPR020806]", "Polymerase, nucleotidyl transferase domain [IPR002934]", "Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2 [IPR034798]", "Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain [IPR032319]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain [IPR015848]", "Polysaccharide biosynthesis domain [IPR021148]", "Pop1, N-terminal [IPR009723]", "Porphobilinogen deaminase, C-terminal [IPR022418]", "Porphobilinogen deaminase, N-terminal [IPR022417]", "Possible tRNA binding domain [IPR027992]", "Post-SET domain [IPR003616]", "Potassium channel tetramerisation-type BTB domain [IPR003131]", "Potentiating neddylation domain [IPR005176]", "Pre-PUA domain [IPR041366]", "Pre-SET domain [IPR007728]", "Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term [IPR021718]", "Pre-mRNA polyadenylation factor Fip1 domain [IPR007854]", "Pre-mRNA processing factor 4 (PRP4)-like [IPR014906]", "Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal [IPR021786]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding [IPR019581]", "Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding [IPR019580]", "Pre-mRNA-splicing factor 19 [IPR013915]", "Pre-mRNA-splicing factor 3 [IPR013881]", "Pre-rRNA-processing protein Ipi1, N-terminal [IPR024679]", "Pre-rRNA-processing protein RIX1, N-terminal [IPR012583]", "Prenylcysteine lyase [IPR010795]", "Probable RNA-binding protein 19, RNA recognition motif 1 [IPR034418]", "Probable RNA-binding protein 19, RNA recognition motif 2 [IPR034417]", "Probable RNA-binding protein 19, RNA recognition motif 3 [IPR034419]", "Probable RNA-binding protein 19, RNA recognition motif 4 [IPR034420]", "Probable RNA-binding protein 19, RNA recognition motif 5 [IPR034423]", "Probable RNA-binding protein 19, RNA recognition motif 6 [IPR034421]", "Proliferating cell nuclear antigen, PCNA, C-terminal [IPR022649]", "Proliferating cell nuclear antigen, PCNA, N-terminal [IPR022648]", "Proline-tRNA ligase, class II, C-terminal [IPR016061]", "Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]", "Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547]", "Prolyl 4-hydroxylase, alpha subunit [IPR006620]", "Prolyl-tRNA synthetase, catalytic domain [IPR033721]", "Propionyl-coenzyme A carboxylase, BT domain [IPR041265]", "Prostaglandin E synthase 2, C-terminal [IPR034335]", "Proteasomal ATPase OB C-terminal domain [IPR032501]", "Proteasome activator PA28, C-terminal domain [IPR003186]", "Proteasome activator PA28, N-terminal domain [IPR003185]", "Proteasome alpha-subunit, N-terminal domain [IPR000426]", "Proteasome beta subunit, C-terminal [IPR024689]", "Proteasome component (PCI) domain [IPR000717]", "Protein FAM210A/B-like domain [IPR009688]", "Protein Kinase B beta, catalytic domain [IPR034677]", "Protein Kinase B, pleckstrin homology domain [IPR039026]", "Protein O-mannosyl-transferase TMTC, DUF1736 [IPR013618]", "Protein RED, C-terminal [IPR012492]", "Protein disulfide-isomerase A3, first redox inactive TRX-like domain b [IPR041868]", "Protein disulfide-isomerase A4, TRX-like domain b [IPR041866]", "Protein kinase A anchor protein, nuclear localisation signal domain [IPR019510]", "Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [IPR002219]", "Protein kinase domain [IPR000719]", "Protein kinase, C-terminal [IPR017892]", "Protein of unknown function DUF3504 [IPR021893]", "Protein of unknown function DUF3715 [IPR022188]", "Protein phosphatase 1 binding domain [IPR029334]", "Protein polybromo-1, Bromodomain 5 [IPR037968]", "Protein quaking, putative nuclear localisation signal [IPR032367]", "Protein-only RNase P, C-terminal [IPR031595]", "Protein-tyrosine phosphatase, catalytic [IPR003595]", "Prp31 C-terminal [IPR019175]", "Pseudouridine synthase I, TruA, alpha/beta domain [IPR020097]", "Pseudouridine synthase II, N-terminal [IPR002501]", "Pseudouridine synthase, RsuA/RluA-like [IPR006145]", "Pseudouridine synthase, TruD, insertion domain [IPR011760]", "Pterin-binding domain [IPR000489]", "Pumilio homology domain [IPR033133]", "Pumilio, RNA binding domain [IPR033712]", "PurE domain [IPR000031]", "PurM-like, C-terminal domain [IPR010918]", "PurM-like, N-terminal domain [IPR016188]", "Putative 5-3 exonuclease [IPR004859]", "Putative RNA methylase domain [IPR000241]", "Putative RNA-binding protein 27, RNA recognition motif [IPR034451]", "Putative RNA-binding protein 47, RNA recognition motif 2 [IPR034440]", "Putative RNA-binding protein 47, RNA recognition motif 3 [IPR034445]", "Putative WW-binding domain and destruction box [IPR033461]", "Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain [IPR004099]", "Pyridoxamine kinase/Phosphomethylpyrimidine kinase [IPR013749]", "Pyrroline-5-carboxylate reductase, catalytic, N-terminal [IPR028939]", "Pyrroline-5-carboxylate reductase, dimerisation domain [IPR029036]", "Pyruvate carboxyltransferase [IPR000891]", "Pyruvate kinase, C-terminal [IPR015795]", "Pyruvate kinase, barrel [IPR015793]", "R3H domain [IPR001374]", "RABX5, catalytic core helical domain [IPR041545]", "RAD23A/RAD23B, UBA1 domain [IPR041811]", "RAD50, zinc hook [IPR013134]", "RAP domain [IPR013584]", "RAWUL domain [IPR032443]", "RBB1NT [IPR012603]", "RBM10, OCRE domain [IPR035618]", "RBM12, RNA recognition motif 1 [IPR034591]", "RBM12, RNA recognition motif 2 [IPR034594]", "RBM12, RNA recognition motif 3 [IPR034855]", "RBM12, RNA recognition motif 4 [IPR034856]", "RBM12, RNA recognition motif 5 [IPR034854]", "RBM12B, RNA recognition motif 2 [IPR034588]", "RBM12B, RNA recognition motif 3 [IPR034858]", "RBM14, RNA recognition motif 1 [IPR034506]", "RBM14, RNA recognition motif 2 [IPR034507]", "RBM15, RNA recognition motif 1 [IPR034470]", "RBM15, RNA recognition motif 2 [IPR034472]", "RBM15, RNA recognition motif 3 [IPR034473]", "RBM1CTR [IPR012604]", "RBM25, RNA recognition motif [IPR034268]", "RBM26, RNA recognition motif 1 [IPR034859]", "RBM26-like, RNA recognition motif 2 [IPR039511]", "RBM3/CIRBP, RNA recognition motif [IPR034278]", "RBM34, RNA recognition motif 1 [IPR034220]", "RBM34, RNA recognition motif 2 [IPR034221]", "RBM4, RNA recognition motif 1 [IPR034897]", "RBM4, RNA recognition motif 2 [IPR034898]", "RBM42, RNA recognition motif [IPR034215]", "RBM45, RNA recognition motif 1 [IPR034203]", "RBM45, RNA recognition motif 2 [IPR034206]", "RBM45, RNA recognition motif 3 [IPR034207]", "RBM45, RNA recognition motif 4 [IPR034208]", "RBM6, OCRE domain [IPR035617]", "RBM6, RNA recognition motif 1 [IPR034123]", "RBM6, RNA recognition motif 2 [IPR034125]", "RBM7, RNA recognition motif [IPR034500]", "RBM8, RNA recognition motif [IPR033744]", "RBP-J/Cbf11/Cbf12, DNA binding [IPR015351]", "RBP-Jkappa, IPT domain [IPR038007]", "RED-like, N-terminal [IPR012916]", "RH1 domain [IPR034743]", "RH2 domain [IPR034744]", "RHIM domain [IPR025735]", "RII binding domain [IPR018459]", "RING finger protein 219, RING finger [IPR035691]", "RING-type zinc-finger, LisH dimerisation motif [IPR027370]", "RIO kinase [IPR000687]", "RIO2 kinase winged helix domain, N-terminal [IPR015285]", "RIP1, Death domain [IPR037934]", "RL domain [IPR041252]", "RLI, domain 1 [IPR034348]", "RNA 3'-terminal phosphate cyclase domain [IPR023797]", "RNA 3'-terminal phosphate cyclase, insert domain [IPR013791]", "RNA binding activity-knot of a chromodomain [IPR025995]", "RNA exonuclease 4, DEDDh 3'-5' exonuclease domain [IPR037431]", "RNA helicase UPF1, 1B domain [IPR040812]", "RNA helicase UPF1, Cys/His rich zinc-binding domain [IPR018999]", "RNA helicase, DEAD-box type, Q motif [IPR014014]", "RNA methyltransferase bin3, C-terminal [IPR010675]", "RNA polymerase III Rpc82, C -terminal [IPR008806]", "RNA polymerase III subunit RPC82-related, helix-turn-helix [IPR013197]", "RNA polymerase Rpb1, domain 1 [IPR007080]", "RNA polymerase Rpb1, domain 3 [IPR007066]", "RNA polymerase Rpb1, domain 4 [IPR007083]", "RNA polymerase Rpb1, domain 5 [IPR007081]", "RNA polymerase Rpb1, domain 6 [IPR007075]", "RNA polymerase Rpb1, domain 7 [IPR007073]", "RNA polymerase Rpb2, domain 2 [IPR007642]", "RNA polymerase Rpb2, domain 3 [IPR007645]", "RNA polymerase Rpb2, domain 4 [IPR007646]", "RNA polymerase Rpb2, domain 5 [IPR007647]", "RNA polymerase Rpb2, domain 7 [IPR007641]", "RNA polymerase Rpb4/RPC9, core [IPR006590]", "RNA polymerase Rpb7-like , N-terminal [IPR005576]", "RNA polymerase, N-terminal [IPR006592]", "RNA polymerase, Rpb5, N-terminal [IPR005571]", "RNA polymerase, alpha subunit [IPR000722]", "RNA polymerase, beta subunit, protrusion [IPR007644]", "RNA polymerase, subunit H/Rpb5 C-terminal [IPR000783]", "RNA recognition motif domain [IPR000504]", "RNA recognition motif domain, eukaryote [IPR003954]", "RNA recognition motif, spliceosomal PrP8 [IPR019582]", "RNA-binding S4 domain [IPR002942]", "RNA-binding domain, S1 [IPR022967]", "RNA-binding protein 10, RNA recognition motif 2 [IPR034992]", "RNA-binding protein 5, RNA recognition motif 1 [IPR034991]", "RNA-binding protein 5, RNA recognition motif 2 [IPR034993]", "RNA-binding protein Musashi homologue, RNA recognition motif 1 [IPR034130]", "RNA-binding protein Musashi homologue, RNA recognition motif 2 [IPR034126]", "RNA-polymerase II-associated protein 3-like, C-terminal domain [IPR025986]", "RNA-recognition motif (RRM) Nup35-type domain [IPR007846]", "RNPS1, RNA recognition motif [IPR034201]", "RNase L inhibitor RLI-like, possible metal-binding domain [IPR007209]", "ROCK, Rho binding domain [IPR015008]", "ROK, N-terminal [IPR012987]", "RPN1, N-terminal [IPR040892]", "RQC domain [IPR018982]", "RUN domain [IPR004012]", "Rab geranylgeranyltransferase, alpha subunit, insert-domain [IPR009087]", "Rab-GTPase-TBC domain [IPR000195]", "Rab-binding domain FIP-RBD [IPR019018]", "Rab3-GAP regulatory subunit, N-terminal [IPR032839]", "Rab3GAP catalytic subunit, C-terminal [IPR045698]", "Rab3GAP catalytic subunit, conserved domain [IPR026147]", "Rab3GAP regulatory subunit, C-terminal [IPR029257]", "Rabaptin coiled-coil domain [IPR018514]", "Rabaptin, GTPase-Rab5 binding domain [IPR015390]", "Rad21/Rec8-like protein, C-terminal, eukaryotic [IPR006909]", "Rad21/Rec8-like protein, N-terminal [IPR006910]", "Rad50, ATP-binding cassette domain [IPR045171]", "Rad50/SbcC-type AAA domain [IPR038729]", "Rad60/SUMO-like domain [IPR022617]", "Radical SAM [IPR007197]", "Radical SAM, C-terminal extension [IPR032432]", "Raly, RNA recognition motif [IPR034502]", "Ran binding domain [IPR000156]", "Ran-GTPase activating protein 1, C-terminal [IPR009109]", "Ran-specific GTPase-activating protein 1, Ran-binding domain [IPR045256]", "Rap/Ran-GAP domain [IPR000331]", "Rap1 Myb domain [IPR015010]", "Ras GTPase-activating domain [IPR001936]", "Ras GTPase-activating protein 1, C-terminal SH2 domain [IPR035842]", "Ras GTPase-activating protein 1, N-terminal SH2 domain [IPR035841]", "Ras guanine-nucleotide exchange factors catalytic domain [IPR001895]", "Ras-associating (RA) domain [IPR000159]", "Ras-like guanine nucleotide exchange factor, N-terminal [IPR000651]", "RasGAP protein, C-terminal [IPR000593]", "RasGAP, SH3 domain [IPR035652]", "RecF/RecN/SMC, N-terminal [IPR003395]", "Redoxin [IPR013740]", "Replication factor A, C-terminal [IPR013955]", "Replication factor C, C-terminal [IPR013748]", "Replication factor Mcm10, C-terminal [IPR015411]", "Replication factor-A protein 1, N-terminal [IPR007199]", "Replication protein A, C-terminal [IPR014892]", "Replication protein A, OB domain [IPR031657]", "Replication termination factor 2, RING-finger [IPR027799]", "Reticulon [IPR003388]", "Rho GTPase-activating protein domain [IPR000198]", "Rho GTPase-binding/formin homology 3 (GBD/FH3) domain [IPR014768]", "Rho guanine nucleotide exchange factor 7, SH3 domain [IPR035789]", "Rho-associated protein kinase 1, HR1 [IPR037310]", "Rho-associated protein kinase 2, HR1 domain [IPR037311]", "Rhodanese-like domain [IPR001763]", "Ribonuclease H1, N-terminal [IPR011320]", "Ribonuclease HII/HIII domain [IPR024567]", "Ribonuclease II/R [IPR001900]", "Ribonuclease III domain [IPR000999]", "Ribonuclease, PIN domain [IPR033411]", "Ribonucleoprotein PTB-binding 1, RNA recognition motif 1 [IPR034633]", "Ribonucleotide reductase large subunit, C-terminal [IPR000788]", "Ribonucleotide reductase large subunit, N-terminal [IPR013509]", "Ribonucleotide reductase, class I , alpha subunit [IPR013346]", "Ribose-phosphate pyrophosphokinase, N-terminal domain [IPR029099]", "Ribosomal L28e/Mak16 [IPR029004]", "Ribosomal Protein L6, KOW domain [IPR041997]", "Ribosomal Proteins L2, RNA binding domain [IPR022666]", "Ribosomal RNA adenine methylase transferase, N-terminal [IPR020598]", "Ribosomal RNA methyltransferase FtsJ domain [IPR002877]", "Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381 [IPR024576]", "Ribosomal RNA methyltransferase, Spb1, C-terminal [IPR012920]", "Ribosomal RNA small subunit methyltransferase F, N-terminal [IPR031341]", "Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain [IPR029190]", "Ribosomal RNA-processing protein 7, C-terminal domain [IPR024326]", "Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906]", "Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A [IPR023573]", "Ribosomal protein L10e/L16 [IPR016180]", "Ribosomal protein L11, C-terminal [IPR020783]", "Ribosomal protein L11, N-terminal [IPR020784]", "Ribosomal protein L14, KOW motif [IPR041985]", "Ribosomal protein L14e domain [IPR002784]", "Ribosomal protein L18e/L15P [IPR021131]", "Ribosomal protein L19, eukaryotic [IPR033935]", "Ribosomal protein L19/L19e [IPR000196]", "Ribosomal protein L2, C-terminal [IPR022669]", "Ribosomal protein L23/L25, N-terminal [IPR005633]", "Ribosomal protein L26/L24, KOW domain [IPR041988]", "Ribosomal protein L30, N-terminal [IPR012988]", "Ribosomal protein L30, ferredoxin-like fold domain [IPR016082]", "Ribosomal protein L46, N-terminal [IPR021757]", "Ribosomal protein L5 eukaryotic, C-terminal [IPR025607]", "Ribosomal protein L5, C-terminal [IPR031309]", "Ribosomal protein L5, N-terminal [IPR031310]", "Ribosomal protein L6, N-terminal [IPR005568]", "Ribosomal protein L6, alpha-beta domain [IPR020040]", "Ribosomal protein L7, eukaryotic/archaeal [IPR035808]", "Ribosomal protein L7/L12, C-terminal [IPR013823]", "Ribosomal protein L7/L12, oligomerisation [IPR008932]", "Ribosomal protein L7Ae/L30e/S12e/Gadd45 [IPR004038]", "Ribosomal protein L9, N-terminal [IPR020070]", "Ribosomal protein S10 domain [IPR027486]", "Ribosomal protein S13/S15, N-terminal [IPR012606]", "Ribosomal protein S23/S25, mitochondrial [IPR023611]", "Ribosomal protein S24/S35, mitochondrial, conserved domain [IPR019349]", "Ribosomal protein S3, C-terminal [IPR001351]", "Ribosomal protein S4, KOW domain [IPR041982]", "Ribosomal protein S4/S9, N-terminal [IPR001912]", "Ribosomal protein S4e, N-terminal [IPR013843]", "Ribosomal protein S4e, central region [IPR013845]", "Ribosomal protein S5, C-terminal [IPR005324]", "Ribosomal protein S5, N-terminal [IPR013810]", "Ribosomal protein S6 kinase alpha-3, C-terminal catalytic domain [IPR041905]", "Ribosomal protein S7 domain [IPR023798]", "Ribosomal protein/NADH dehydrogenase domain [IPR007741]", "Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034]", "Ribosome biogenesis protein Bms1, N-terminal [IPR037875]", "Ribosome maturation protein Sdo1/SBDS, C-terminal [IPR018978]", "Ribosome maturation protein Sdo1/SBDS, N-terminal [IPR019783]", "Ribosome receptor lysine/proline rich [IPR007794]", "Ribosome-associated complex head domain [IPR032003]", "Ricin B, lectin domain [IPR000772]", "Rieske iron-sulphur protein, C-terminal [IPR005805]", "Right handed beta helix domain [IPR039448]", "RmlD-like substrate binding domain [IPR029903]", "Roadblock/LAMTOR2 domain [IPR004942]", "Rpn11/EIF3F, C-terminal [IPR024969]", "RrmJ-type ribose 2-O-methyltransferase domain [IPR025816]", "Rrp40, S1 domain [IPR037319]", "Rrp44-like cold shock domain [IPR033771]", "Rrp7, RRM-like N-terminal domain [IPR040447]", "Rrp7A, RNA recognition motif [IPR034890]", "RuvB-like, AAA-lid domain [IPR041048]", "S-adenosyl-L-homocysteine hydrolase, NAD binding domain [IPR015878]", "S-adenosylmethionine synthetase, C-terminal [IPR022630]", "S-adenosylmethionine synthetase, N-terminal [IPR022628]", "S-adenosylmethionine synthetase, central domain [IPR022629]", "S1 domain [IPR003029]", "S1-like RNA binding domain [IPR025223]", "S100/CaBP-9k-type, calcium binding, subdomain [IPR013787]", "SAB domain [IPR007477]", "SAC domain [IPR002013]", "SAC3/GANP/THP3, conserved domain [IPR005062]", "SAF domain [IPR013974]", "SAICAR synthetase/ADE2, N-terminal [IPR028923]", "SAM domain [IPR041418]", "SAM-dependent methyltransferase RsmB/NOP2-type [IPR001678]", "SANT domain [IPR017884]", "SANT/Myb domain [IPR001005]", "SAP domain [IPR003034]", "SARAH domain [IPR011524]", "SART3, RNA recognition motif 1 [IPR034217]", "SART3, RNA recognition motif 2 [IPR034218]", "SCAF4, RNA recognition motif [IPR034369]", "SCP2 sterol-binding domain [IPR003033]", "SDA1 domain [IPR007949]", "SEC23-interacting protein, SAM domain [IPR037603]", "SEP domain [IPR012989]", "SERRATE/Ars2 , C-terminal [IPR007042]", "SERRATE/Ars2, N-terminal [IPR021933]", "SET domain [IPR001214]", "SF3A2 domain [IPR031781]", "SF3A3 domain [IPR031774]", "SF3B4, RNA recognition motif 1 [IPR034158]", "SF3B4, RNA recognition motif 2 [IPR034159]", "SF3B6, RNA recognition motif [IPR034150]", "SGNH hydrolase-type esterase domain [IPR013830]", "SGS domain [IPR007699]", "SGTA, homodimerisation domain [IPR032374]", "SH2 domain [IPR000980]", "SH3 domain [IPR001452]", "SH3-like domain, bacterial-type [IPR003646]", "SHARP, RNA recognition motif 1 [IPR034172]", "SHARP, RNA recognition motif 2 [IPR034173]", "SHARP, RNA recognition motif 3 [IPR034174]", "SHARP, RNA recognition motif 4 [IPR034175]", "SIS domain [IPR001347]", "SKI-interacting protein SKIP, SNW domain [IPR004015]", "SKICH domain [IPR041611]", "SKP1 component, POZ domain [IPR016073]", "SKP1 component, dimerisation [IPR016072]", "SLC12A transporter, C-terminal [IPR018491]", "SLED domain [IPR021987]", "SLIDE domain [IPR015195]", "SLIRP, RNA recognition motif [IPR034152]", "SMARCA1, N-terminal [IPR044755]", "SMARCC, C-terminal [IPR032451]", "SMARCC, N-terminal [IPR032450]", "SMARCC, SWIRM-associated domain [IPR032448]", "SMCs flexible hinge [IPR010935]", "SNAP-25 domain [IPR000928]", "SNARE-complex protein Syntaxin-18, N-terminal [IPR019529]", "SNF2, N-terminal [IPR000330]", "SNX17, atypical FERM-like domain [IPR037836]", "SNX2, PX domain [IPR037918]", "SNX5, PX domain [IPR042135]", "SNX6, PX domain [IPR042136]", "SNX9, SH3 domain [IPR035558]", "SPF45, RNA recognition motif [IPR034653]", "SPIN90, SH3 domain [IPR035514]", "SPIN90/Ldb17, leucine-rich domain [IPR018556]", "SPRY domain [IPR003877]", "SPRY-associated [IPR006574]", "SR140, RNA recognition motif [IPR035009]", "SRA-YDG [IPR003105]", "SRCR domain [IPR001190]", "SRCR-like domain [IPR017448]", "SREK1, RNA recognition motif 2 [IPR034192]", "SRP9 domain [IPR039432]", "SRSF1, RNA recognition motif 1 [IPR034520]", "SRSF6, RNA recognition motif 1 [IPR034511]", "SRSF7, RNA recognition motif [IPR034651]", "SRSF9, RNA recognition motif 1 [IPR034503]", "SRSF9, RNA recognition motif 2 [IPR034995]", "SSRP1 domain [IPR024954]", "STAG [IPR013721]", "STAM1, SH3 domain [IPR035657]", "STAMBP/STALP-like, MPN domain [IPR044098]", "STAR protein, homodimerisation region [IPR032377]", "STARD7, START domain [IPR041949]", "START domain [IPR002913]", "STAT transcription factor, DNA-binding [IPR013801]", "STAT transcription factor, all-alpha domain [IPR013800]", "STAT transcription factor, protein interaction [IPR013799]", "STAT1, SH2 domain [IPR035859]", "STAT3, SH2 domain [IPR035855]", "STI1 domain [IPR041243]", "STRBP, first double-stranded RNA binding domain [IPR044472]", "SUI1 domain [IPR001950]", "SUMO-activating enzyme subunit 2, C-terminal domain [IPR032426]", "SUN coiled coil domain 2 [IPR040994]", "SUN domain [IPR012919]", "SUN domain-containing protein 1, N-terminal [IPR032680]", "SUZ-C domain [IPR024642]", "SWAP/Surp [IPR000061]", "SWI/SNF-like complex subunit BAF250, C-terminal [IPR033388]", "SWIB domain [IPR019835]", "SWIB/MDM2 domain [IPR003121]", "SWIRM domain [IPR007526]", "Saccharopine dehydrogenase, NADP binding domain [IPR005097]", "Saccharopine dehydrogenase-like, C-terminal [IPR032095]", "Sam68, tyrosine-rich domain [IPR032335]", "Saposin B type domain [IPR008139]", "Sas10 C-terminal domain [IPR018972]", "Schlafen group 3-like, DNA/RNA helicase domain [IPR018647]", "Schlafen, AlbA_2 domain [IPR007421]", "Sec16, central conserved domain [IPR024340]", "Sec23, C-terminal [IPR037550]", "Sec23/Sec24 beta-sandwich [IPR012990]", "Sec23/Sec24, helical domain [IPR006900]", "Sec23/Sec24, trunk domain [IPR006896]", "Sec24-like, trunk domain [IPR041742]", "Sec39 domain [IPR013244]", "Sec63 domain [IPR004179]", "Sec7 domain [IPR000904]", "Sec8 exocyst complex component specific domain [IPR007191]", "Second polo-box domain [IPR033695]", "Sedolisin domain [IPR030400]", "Sema domain [IPR001627]", "Senescence/spartin-associated, C-terminal [IPR009686]", "Sentrin-specific protease 3/5, conserved domain [IPR045577]", "Septin-type guanine nucleotide-binding (G) domain [IPR030379]", "Sequestosome-1, PB1 domain [IPR034866]", "Sequestosome-1, UBA domain [IPR033741]", "Serine aminopeptidase, S33 [IPR022742]", "Serine hydroxymethyltransferase-like domain [IPR039429]", "Serine-tRNA ligase catalytic core domain [IPR033729]", "Serine-tRNA synthetase, type1, N-terminal [IPR015866]", "Serine-threonine protein phosphatase, N-terminal [IPR031675]", "Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245]", "Serine/arginine-rich splicing factor SRSF4-like, RNA recognition motif 1 [IPR035585]", "Serine/threonine-protein PRP4, catalytic domain [IPR044092]", "Serine/threonine-protein kinase N, C2 domain [IPR037784]", "Serine/threonine-protein kinase N, first HR1 domain [IPR037313]", "Serine/threonine-protein kinase Nek9, catalytic domain [IPR042767]", "Serine/threonine-protein kinase OSR1/WNK, CCT domain [IPR024678]", "Serine/threonine-protein kinase Rio2 [IPR030484]", "Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase [IPR006186]", "Serpin H1, serpin domain [IPR033830]", "Serpin domain [IPR023796]", "Siah interacting protein, N-terminal [IPR015120]", "Signal recognition particle SRP54, helical bundle [IPR013822]", "Signal recognition particle receptor, alpha subunit, N-terminal [IPR007222]", "Signal recognition particle subunit SRP68, RNA-binding domain [IPR034652]", "Signal recognition particle, SRP54 subunit, GTPase domain [IPR000897]", "Signal recognition particle, SRP54 subunit, M-domain [IPR004125]", "Signal recognition particle, SRP72 subunit, RNA-binding [IPR013699]", "Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal [IPR022752]", "Signal transduction histidine kinase-related protein, C-terminal [IPR004358]", "Sin3, C-terminal [IPR031693]", "Sirtuin family, catalytic core domain [IPR026590]", "Sister chromatid cohesion C-terminal domain [IPR024986]", "Ski2, N-terminal domain [IPR040801]", "Sm-like protein Lsm4 [IPR034101]", "Small G protein signalling modulator 1/2, Rab-binding domain [IPR021935]", "Small GTP-binding protein domain [IPR005225]", "Small acidic protein-like domain [IPR028124]", "Small nuclear ribonucleoprotein D1 [IPR034102]", "Small-subunit processome, Utp12 [IPR007148]", "Small-subunit processome, Utp13 [IPR013934]", "Small-subunit processome, Utp21 [IPR007319]", "Smc1, ATP-binding cassette domain [IPR028468]", "Smc2, ATP-binding cassette domain [IPR027120]", "Snf2, ATP coupling domain [IPR029295]", "Snu114, GTP-binding domain [IPR044121]", "Sof1-like protein [IPR007287]", "Solute carrier family 3 member 2, N-terminal domain [IPR031984]", "Sorting Nexin 1, PX domain [IPR034901]", "Sorting nexin Vps5-like, C-terminal [IPR015404]", "Sorting nexin protein, WASP-binding domain [IPR019497]", "Sorting nexin, N-terminal [IPR005329]", "Sorting nexin-17/31, FERM domain [IPR040842]", "Sorting nexin-9, BAR domain [IPR037425]", "Sorting nexin-9, PX domain [IPR037426]", "Spen paralogue and orthologue SPOC, C-terminal [IPR012921]", "Spen paralogue/orthologue C-terminal, metazoa [IPR010912]", "Spermidine synthase, tetramerisation domain [IPR035246]", "Spermine synthase, N-terminal [IPR040900]", "Sphingolipid delta4-desaturase, N-terminal [IPR013866]", "Splicing factor 1, helix-hairpin domain [IPR032570]", "Splicing factor 3A subunit 1, conserved domain [IPR022030]", "Splicing factor 3A subunit 1, ubiquitin domain [IPR035563]", "Splicing factor 3B subunit 1 [IPR015016]", "Splicing factor ELAV/Hu, RNA recognition motif 1 [IPR034775]", "Splicing factor RBM39, linker [IPR029123]", "Splicing factor SF3a60 /Prp9 subunit, C-terminal [IPR024598]", "Splicing factor SF3a60 binding domain [IPR021966]", "Spp2/MOS2, G-patch domain [IPR026822]", "Spt5 C-terminal domain [IPR024945]", "Spt5 transcription elongation factor, N-terminal [IPR022581]", "Spt5, KOW domain repeat 1 [IPR041973]", "Spt5, KOW domain repeat 2 [IPR041975]", "Spt5, KOW domain repeat 3 [IPR041976]", "Spt5, KOW domain repeat 4 [IPR041977]", "Spt5, KOW domain repeat 5 [IPR041978]", "Spt5, KOW domain repeat 6 [IPR041980]", "Spt6 acidic, N-terminal domain [IPR028083]", "Spt6, SH2 domain [IPR035420]", "Spt6, SH2 domain, C terminus [IPR035018]", "Spt6, SH2 domain, N terminus [IPR035019]", "Squalene cyclase, C-terminal [IPR032696]", "Squalene cyclase, N-terminal [IPR032697]", "Squalene epoxidase [IPR013698]", "Srp40, C-terminal [IPR007718]", "Staphylococcal nuclease (SNase-like), OB-fold [IPR016071]", "Staufen 1, third double-stranded RNA binding domain [IPR044475]", "Staufen 2, first double-stranded RNA binding domain [IPR044476]", "Staufen 2, fourth double-stranded RNA binding domain [IPR044474]", "Staufen 2, second double-stranded RNA binding domain [IPR044464]", "Staufen 2, third double-stranded RNA binding domain [IPR044473]", "Staufen, C-terminal [IPR032478]", "Steadiness box (SB) domain [IPR017916]", "Sterile alpha motif domain [IPR001660]", "Sterol-sensing domain [IPR000731]", "Strawberry notch, AAA domain [IPR039187]", "Strawberry notch, helicase C domain [IPR026937]", "Striatin, N-terminal [IPR013258]", "Strictosidine synthase, conserved region [IPR018119]", "Stromalin conservative domain [IPR020839]", "Structural maintenance of chromosomes 3, ABC domain, eukaryotic [IPR041741]", "Structural maintenance of chromosomes 4, ABC domain, eukaryotic [IPR041738]", "Succinate dehydogenase/fumarate reductase N-terminal [IPR025192]", "Sulfatase, N-terminal [IPR000917]", "Sulfatase-modifying factor enzyme [IPR005532]", "Sulfhydryl oxidase, Trx-like domain [IPR041269]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain [IPR040986]", "Sulphate adenylyltransferase [IPR002650]", "Sulphate adenylyltransferase catalytic domain [IPR024951]", "Suppressor of forked [IPR008847]", "Suppressor of white apricot, N-terminal domain [IPR019147]", "Survival motor neuron [IPR010304]", "Suv3, C-terminal domain 1 [IPR041082]", "Suv3, DEXQ-box helicase domain [IPR044774]", "Suv3, N-terminal [IPR041453]", "Symplekin C-terminal [IPR022075]", "Symplekin/Pta1, N-terminal [IPR032460]", "Synaptic functional regulator FMRP, KH0 domain [IPR040472]", "Synaptotagmin, SMP domain [IPR039010]", "Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468]", "Syntaxin 6, N-terminal [IPR015260]", "Syntaxin, N-terminal domain [IPR006011]", "Syntaxin-5, N-terminal, Sly1p-binding domain [IPR021538]", "Syntaxin-8, SNARE domain [IPR041875]", "TAF6, C-terminal HEAT repeat domain [IPR011442]", "TAP C-terminal (TAP-C) domain [IPR005637]", "TAR DNA-binding protein 43, N-terminal [IPR041105]", "TATA box binding protein associated factor (TAF) [IPR004823]", "TATA element modulatory factor 1, TATA binding [IPR022091]", "TATA-binding protein interacting (TIP20) [IPR013932]", "TBCE, ubiquitin-like (Ubl) domain [IPR044079]", "TCB1D9/TCB1D9B, PH-GRAM domain 1 [IPR036014]", "TCB1D9/TCB1D9B, PH-GRAM domain 2 [IPR036017]", "TFG box [IPR025768]", "TFG, PB1 domain [IPR034857]", "TFIIEalpha/SarR/Rpc3 HTH domain [IPR024550]", "TFIIF beta subunit, HTH domain [IPR040450]", "TFIIF, beta subunit, N-terminal [IPR040504]", "TGS [IPR004095]", "THIF-type NAD/FAD binding fold [IPR000594]", "THO complex subunit 2, N-terminal domain [IPR032302]", "THO complex, subunitTHOC2, C-terminal [IPR021418]", "THO complex, subunitTHOC2, N-terminal [IPR021726]", "THUMP domain [IPR004114]", "TIA-1, RNA recognition motif 2 [IPR034830]", "TIA-1, RNA recognition motif 3 [IPR034832]", "TIAR, RNA recognition motif 1 [IPR034492]", "TIAR, RNA recognition motif 2 [IPR034494]", "TIAR, RNA recognition motif 3 [IPR034496]", "TIF1-beta, RING finger, HC subclass [IPR042713]", "TIP49, P-loop domain [IPR010339]", "TOG domain [IPR034085]", "TOPK, catalytic domain [IPR041989]", "TOPRIM domain [IPR006171]", "TPX2 central domain [IPR027330]", "TPX2, C-terminal [IPR027329]", "TRAM domain [IPR002792]", "TRAM/LAG1/CLN8 homology domain [IPR006634]", "TRAM1-like protein [IPR013599]", "TRASH domain [IPR011017]", "TRF2-interacting telomeric protein/Rap1, C-terminal [IPR021661]", "TRIAD supradomain [IPR044066]", "TRIM21, PRY/SPRY domain [IPR035831]", "TRIM25, PRY/SPRY domain [IPR042753]", "TRMT2A, RNA recognition motif [IPR034262]", "TROVE domain [IPR008858]", "TUTase nucleotidyltransferase domain [IPR045100]", "Talin, N-terminal F0 domain [IPR032425]", "Talin, central [IPR015224]", "Talin-1/2, rod-segment [IPR037438]", "Tankyrase 1-binding protein, C-terminal [IPR032764]", "Target SNARE coiled-coil homology domain [IPR000727]", "TatSF1-like, RNA recognition motif 1 [IPR034392]", "TauD/TfdA-like domain [IPR003819]", "Telomerase activating protein Est1, N-terminal [IPR019458]", "Telomere length regulation protein, conserved domain [IPR019337]", "Telomere-associated protein Rif1, N-terminal [IPR022031]", "Tensin phosphatase, C2 domain [IPR014020]", "Tensin-type phosphatase domain [IPR029023]", "Testin, LIM domain 1 [IPR034958]", "Testin, LIM domain 2 [IPR034959]", "Testin, LIM domain 3 [IPR034960]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain [IPR020631]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain [IPR020630]", "Tetratricopeptide repeat protein 7, N-terminal [IPR045819]", "Tetratricopeptide repeat-like domain [IPR018704]", "Tetratricopeptide, SHNi-TPR domain [IPR019544]", "Tfc3, extended winged-helix domain [IPR035625]", "Thiamine pyrophosphate enzyme, C-terminal TPP-binding [IPR011766]", "Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain [IPR012001]", "Thiamine pyrophosphate enzyme, central domain [IPR012000]", "Thioesterase [IPR001031]", "Thioesterase domain [IPR006683]", "Thiolase, C-terminal [IPR020617]", "Thiolase, N-terminal [IPR020616]", "Thioredoxin domain [IPR013766]", "Thioredoxin domain-containing protein 17-like domain [IPR010357]", "Thioredoxin-like fold [IPR012336]", "Thioredoxin-related transmembrane protein 2, thioredoxin domain [IPR037463]", "Threonine-tRNA ligase catalytic core domain [IPR033728]", "Threonyl/alanyl tRNA synthetase, SAD [IPR012947]", "Thymidylate kinase-like domain [IPR039430]", "Thymidylate synthase/dCMP hydroxymethylase domain [IPR023451]", "Tim10-like [IPR004217]", "Tim44-like domain [IPR007379]", "Timeless, C-terminal [IPR007725]", "Timeless, N-terminal [IPR006906]", "Toll-interacting protein, C2 domain [IPR037301]", "Toll-interacting protein, CUE domain [IPR041799]", "Topoisomerase I C-terminal domain [IPR025834]", "Trans-isoprenyl diphosphate synthases, head-to-head [IPR033904]", "Transcription elongation factor S-II, central domain [IPR003618]", "Transcription elongation factor Spt6, YqgF domain [IPR028231]", "Transcription elongation factor Spt6, helix-hairpin-helix motif [IPR032706]", "Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type [IPR003617]", "Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958]", "Transcription factor CP2, SAM domain [IPR037599]", "Transcription factor IIIC subunit 5, HTH domain [IPR019136]", "Transcription factor IIIC subunit Tfc1/Sfc1, triple barrel domain [IPR041499]", "Transcription factor IIIC, 90kDa subunit, N-terminal [IPR024761]", "Transcription factor IIIC, putative zinc-finger [IPR024764]", "Transcription factor IIS, N-terminal [IPR017923]", "Transcription factor TFE/TFIIEalpha HTH domain [IPR017919]", "Transcription factor TFIIB, cyclin-like domain [IPR013150]", "Transcription factor TFIIE alpha subunit, C-terminal [IPR021600]", "Transcription factor Tfb2, C-terminal domain [IPR040662]", "Transcription initiation factor IIE subunit alpha, N-terminal [IPR002853]", "Transcription termination and cleavage factor, C-terminal domain [IPR026896]", "Transcriptional coactivator p15 (PC4), C-terminal [IPR003173]", "Transcriptional repressor p66, coiled-coil MBD2-interaction domain [IPR032346]", "Transferrin receptor protein 1/2, PA domain [IPR037324]", "Transferrin receptor-like, dimerisation domain [IPR007365]", "Transforming acidic coiled-coil-containing protein, C-terminal [IPR007707]", "Transketolase, C-terminal domain [IPR033248]", "Transketolase, N-terminal [IPR005474]", "Transketolase-like, pyrimidine-binding domain [IPR005475]", "Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038]", "Translation elongation factor EFG/EF2, domain IV [IPR005517]", "Translation elongation factor EFTs/EF1B, dimerisation [IPR014039]", "Translation elongation factor EFTu-like, domain 2 [IPR004161]", "Translation elongation factor EFTu/EF1A, C-terminal [IPR004160]", "Translation elongation factor, IF5A C-terminal [IPR020189]", "Translation initiation factor IF- 2, domain 3 [IPR023115]", "Translation initiation factor IF2/IF5 domain [IPR002735]", "Translation initiation factor eIF-2B subunit epsilon, N-terminal [IPR035543]", "Translation initiation factor eIF-2B subunit epsilon, W2 domain [IPR044123]", "Translation initiation factor, beta propellor-like domain [IPR013979]", "Translational (tr)-type GTP-binding domain [IPR000795]", "Translationally controlled tumour protein (TCTP) domain [IPR034737]", "Translocon Sec61/SecY, plug domain [IPR019561]", "Transmembrane protein 201, C-terminal [IPR018861]", "Treacle protein domain [IPR003993]", "Tripeptidyl-peptidase II domain [IPR034051]", "TrmE-type guanine nucleotide-binding domain [IPR031168]", "TryX and NRX, thioredoxin domain [IPR045870]", "Tuberin, N-terminal [IPR024584]", "Tuberin-type domain [IPR018515]", "Tubulin-folding cofactor B, N-terminal ubiquitin-like domain [IPR045172]", "Tubulin-specific chaperone D, C-terminal [IPR022577]", "Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]", "Tubulin/FtsZ, GTPase domain [IPR003008]", "Tudor domain [IPR002999]", "Tumour suppressor p53-binding protein-1 Tudor domain [IPR015125]", "Tyrosine-protein kinase BAZ1B, bromodomain [IPR037375]", "Tyrosine-protein kinase ephrin type A/B receptor-like [IPR011641]", "Tyrosine-protein kinase, catalytic domain [IPR020635]", "Tyrosine-specific protein phosphatase, PTPase domain [IPR000242]", "Tyrosine-specific protein phosphatases domain [IPR000387]", "U-box domain [IPR003613]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 1 [IPR034407]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 2 [IPR034409]", "U1 small nuclear ribonucleoprotein of 70kDa N-terminal [IPR022023]", "U1-C, C2H2-type zinc finger [IPR013085]", "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 2 [IPR034562]", "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 1 [IPR034564]", "U2A'/phosphoprotein 32 family A, C-terminal [IPR003603]", "U3 small nucleolar RNA-associated protein 10, N-terminal [IPR022125]", "U3 small nucleolar RNA-associated protein 15, C-terminal [IPR018983]", "UAS [IPR006577]", "UBAC1, UBA domain 1 [IPR041926]", "UBAC1, UBA domain 2 [IPR041927]", "UBX domain [IPR001012]", "UBXN1, UBA domain [IPR041923]", "UDP-glucose/GDP-mannose dehydrogenase, C-terminal [IPR014027]", "UDP-glucose/GDP-mannose dehydrogenase, N-terminal [IPR001732]", "UDP-glucose/GDP-mannose dehydrogenase, dimerisation [IPR014026]", "UDP-glucose:glycoprotein glucosyltransferase, thioredoxin-like domain 4 [IPR040525]", "UGGT, thioredoxin-like domain 1 [IPR040693]", "UGGT, thioredoxin-like domain 2 [IPR040694]", "UGGT, thioredoxin-like domain 3 [IPR040692]", "UHRF1, tandem tudor domain [IPR021991]", "UNC-45/Cro1/She4, central domain [IPR024660]", "UPF0113, PUA domain [IPR005155]", "UPF0113, pre-PUA domain [IPR040598]", "UPF3 domain [IPR005120]", "UPF3B, RNA recognition motif-like domain [IPR034979]", "USP8 dimerisation domain [IPR015063]", "UVR domain [IPR001943]", "Ubiquinol-cytochrome c reductase 8kDa, N-terminal [IPR015248]", "Ubiquinol-cytochrome c reductase, iron-sulphur subunit [IPR006317]", "Ubiquitin E2 variant, N-terminal [IPR008883]", "Ubiquitin carboxyl-terminal hydrolase 47, C-terminal [IPR045578]", "Ubiquitin carboxyl-terminal hydrolase 5, UBA1 domain [IPR041812]", "Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain [IPR024729]", "Ubiquitin carboxyl-terminal hydrolase, C-terminal [IPR029346]", "Ubiquitin conjugation factor E4, core [IPR019474]", "Ubiquitin specific protease domain [IPR028889]", "Ubiquitin system component CUE [IPR003892]", "Ubiquitin-activating enzyme E1, C-terminal [IPR018965]", "Ubiquitin-activating enzyme E1, FCCH domain [IPR032418]", "Ubiquitin-activating enzyme E1, four-helix bundle [IPR032420]", "Ubiquitin-activating enzyme, SCCH domain [IPR019572]", "Ubiquitin-associated domain [IPR015940]", "Ubiquitin-conjugating enzyme E2 [IPR000608]", "Ubiquitin-like domain [IPR000626]", "Ubiquitin-like domain, USP-type [IPR028135]", "Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain [IPR032353]", "Ubiquitin-specific peptidase 48 [IPR033841]", "Ubiquitin-specific-processing protease 48, Ubl domain [IPR044743]", "Ubiquitin/SUMO-activating enzyme ubiquitin-like domain [IPR028077]", "Ubiquitinyl hydrolase, variant UBP zinc finger [IPR041432]", "Ubiquitinyl hydrolase-L5 [IPR033837]", "Ulp1 protease family, C-terminal catalytic domain [IPR003653]", "Uncharacterised domain CHP00451 [IPR004521]", "Uncharacterised domain NUC130/133, N-terminal [IPR012977]", "Uncharacterised domain NUC173 [IPR012978]", "Uncharacterised domain NUC202 [IPR012980]", "Upstream-binding protein 1, SAM domain [IPR037600]", "Uracil-DNA glycosylase-like [IPR005122]", "Uroporphyrinogen decarboxylase (URO-D) [IPR000257]", "Uso1/p115-like vesicle tethering protein, C-terminal [IPR006955]", "VASP tetramerisation [IPR014885]", "VHS domain [IPR002014]", "VIP36, lectin domain [IPR035664]", "VPS13, repeated coiled region [IPR031642]", "VPS9 domain [IPR003123]", "Vacuolar protein sorting-associated protein 13, C-terminal [IPR031645]", "Vacuolar protein sorting-associated protein 13, SHR-binding domain [IPR009543]", "Vacuolar protein sorting-associated protein 13, second N-terminal domain [IPR031646]", "Vacuolar protein sorting-associated protein 13-like, N-terminal domain [IPR026854]", "Vacuolar protein sorting-associated protein 4, MIT domain [IPR045253]", "Valyl tRNA synthetase, anticodon-binding domain [IPR033705]", "Vertebrate SNX3, PX domain [IPR042137]", "Vertebrate ubiquitin-conjugating enzyme E2 K, UBA domain [IPR042599]", "Vesicle tethering protein Uso1/P115-like , head domain [IPR006953]", "Vicinal oxygen chelate (VOC) domain [IPR037523]", "Vinculin-binding site-containing domain [IPR015009]", "Virilizer, N-terminal [IPR031801]", "Vitamin B12-dependent methionine synthase, activation domain [IPR004223]", "Vitamin K epoxide reductase [IPR012932]", "Vps16, C-terminal [IPR006925]", "Vps16, N-terminal [IPR006926]", "Vps4 oligomerisation, C-terminal [IPR015415]", "Vps53-like, N-terminal [IPR007234]", "W2 domain [IPR003307]", "WAPL domain [IPR012502]", "WD repeat-containing protein 18, C-terminal domain [IPR026987]", "WGR domain [IPR008893]", "WH1/EVH1 domain [IPR000697]", "WH2 domain [IPR003124]", "WHEP-TRS domain [IPR000738]", "WHIM1 domain [IPR028942]", "WHIM2 domain [IPR028941]", "WSTF/Acf1/Cbp146 [IPR013136]", "WW domain [IPR001202]", "WWE domain [IPR004170]", "Wings apart-like protein, C-terminal [IPR022771]", "Wolframin, EF-hand domain [IPR045460]", "Wolframin, OB-fold domain [IPR045461]", "Wolframin, cysteine-rich domain [IPR045400]", "XPA, C-terminal [IPR022656]", "XPC-binding domain [IPR015360]", "XPG, N-terminal [IPR006085]", "XPG-I domain [IPR006086]", "XRCC1, first (central) BRCT domain [IPR045080]", "XRN2-binding (XTBD) domain [IPR021859]", "Xrn1, helical domain [IPR041412]", "YKT6, SNARE motif [IPR045848]", "YTH domain [IPR007275]", "YchF, C-terminal domain [IPR013029]", "YchF, N-terminal [IPR041706]", "Yip1 domain [IPR006977]", "YjeF N-terminal domain [IPR004443]", "YqgF/RNase H-like domain [IPR006641]", "Z-binding domain [IPR042371]", "ZAP, helix turn helix N-terminal domain [IPR041360]", "ZAP, zinc finger [IPR040954]", "ZC3H15/TMA46 family, C-terminal [IPR032378]", "ZN598/Hel2, RING finger [IPR041888]", "ZO-1, SH3 domain [IPR035597]", "ZO-2, SH3 domain [IPR035598]", "ZU5 domain [IPR000906]", "ZZZ3, zinc finger, ZZ-type [IPR041981]", "Zasp-like motif [IPR006643]", "Zinc finger C2H2 AKAP95-type [IPR034736]", "Zinc finger C2H2-type [IPR013087]", "Zinc finger, A20-type [IPR002653]", "Zinc finger, B-box, chordata [IPR020457]", "Zinc finger, C2H2, LYAR-type [IPR014898]", "Zinc finger, C2HC5-type [IPR009349]", "Zinc finger, C3HC-like [IPR012935]", "Zinc finger, C3HC4 RING-type [IPR018957]", "Zinc finger, C5HC2-type [IPR004198]", "Zinc finger, CCCH-type [IPR000571]", "Zinc finger, CCHC-type [IPR001878]", "Zinc finger, CHCC-type [IPR019401]", "Zinc finger, CHHC-type [IPR012996]", "Zinc finger, CW-type [IPR011124]", "Zinc finger, CXXC-type [IPR002857]", "Zinc finger, ClpX C4-type [IPR010603]", "Zinc finger, DNA-directed DNA polymerase, family B, alpha [IPR015088]", "Zinc finger, FCS-type [IPR012313]", "Zinc finger, FPG/IleRS-type [IPR010663]", "Zinc finger, FYVE-related [IPR017455]", "Zinc finger, GATA-type [IPR000679]", "Zinc finger, GRF-type [IPR010666]", "Zinc finger, LIM-type [IPR001781]", "Zinc finger, MIZ-type [IPR004181]", "Zinc finger, MYM-type [IPR010507]", "Zinc finger, MYND-type [IPR002893]", "Zinc finger, Mcm10/DnaG-type [IPR015408]", "Zinc finger, NF-X1-type [IPR000967]", "Zinc finger, PARP-type [IPR001510]", "Zinc finger, PHD-finger [IPR019787]", "Zinc finger, PHD-type [IPR001965]", "Zinc finger, RING-CH-type [IPR011016]", "Zinc finger, RING-type [IPR001841]", "Zinc finger, RanBP2-type [IPR001876]", "Zinc finger, Sec23/Sec24-type [IPR006895]", "Zinc finger, TFIIB-type [IPR013137]", "Zinc finger, TFIIS-type [IPR001222]", "Zinc finger, UBP-type [IPR001607]", "Zinc finger, UBR-type [IPR003126]", "Zinc finger, ZPR1-type [IPR004457]", "Zinc finger, ZZ-type [IPR000433]", "Zinc finger, double-stranded RNA binding [IPR022755]", "Zinc knuckle CX2CX3GHX4C [IPR025829]", "Zinc-finger CCCH domain [IPR041686]", "Zinc-ribbon domain [IPR026870]", "Zn-dependent metallo-hydrolase, RNA specificity domain [IPR011108]", "cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117]", "cGMP-dependent protein kinase, interacting domain [IPR031775]", "dUTPase, trimeric [IPR033704]", "dUTPase-like [IPR029054]", "eIF3 subunit M, C-terminal helix domain [IPR040750]", "eIF3B, RNA recognition motif [IPR034363]", "eIF3G, RNA recognition motif [IPR034240]", "eIF3h, C-terminal [IPR045810]", "eIF4H, RNA recognition motif [IPR034229]", "eRF1 domain 1/Pelota-like [IPR005140]", "eRF1 domain 2 [IPR005141]", "eRF1 domain 3 [IPR005142]", "hnRNP A0, RNA recognition motif 1 [IPR034801]", "hnRNP A1, RNA recognition motif 1 [IPR034845]", "hnRNP A1, RNA recognition motif 2 [IPR034803]", "hnRNP A2/B1, RNA recognition motif 1 [IPR034486]", "hnRNP A3, RNA recognition motif 1 [IPR034513]", "hnRNP A3, RNA recognition motif 2 [IPR034516]", "hnRNP DL, RNA recognition motif 1 [IPR034847]", "hnRNP-L, RNA recognition motif 1 [IPR035005]", "hnRNP-L, RNA recognition motif 2 [IPR035008]", "hnRNP-L, RNA recognition motif 3 [IPR034816]", "hnRNP-L, RNA recognition motif 4 [IPR034817]", "hnRNPAB, RNA recognition motif 1 [IPR034846]", "hnRNPH3, RNA recognition motif 2 [IPR034970]", "hnRNPH3, RNA recognition motif 3 [IPR034969]", "hnRNPM, RNA recognition motif 3 [IPR034990]", "hnRPLL, RNA recognition motif 1 [IPR034985]", "hnRPLL, RNA recognition motif 2 [IPR034986]", "hnRPLL, RNA recognition motif 3 [IPR034983]", "hnRPLL, RNA recognition motif 4 [IPR034987]", "mRNA (guanine-N(7))-methyltransferase domain [IPR004971]", "mRNA splicing factor Cwf21 domain [IPR013170]", "mRNA-decapping enzyme, C-terminal [IPR031953]", "p21 activated kinase binding domain [IPR033923]", "p21-activated kinase 2, catalytic domain [IPR035064]", "p53 transactivation domain [IPR013872]", "p53, DNA-binding domain [IPR011615]", "p53, tetramerisation domain [IPR010991]", "p54nrb, RNA recognition motif 1 [IPR034552]", "rRNA-processing arch domain [IPR025696]", "snRNP70, RNA recognition motif [IPR034143]", "tRNA methyltransferase TRM10-type domain [IPR028564]", "tRNA methyltransferase TRMD/TRM10-type domain [IPR016009]", "tRNA pseudouridylate synthase B, C-terminal [IPR032819]", "tRNA synthetase, B5-domain [IPR005147]", "tRNA synthetases class I, catalytic domain [IPR032678]", "tRNA(Met) cytidine acetyltransferase TmcA, N-terminal [IPR013562]", "tRNA-binding domain [IPR002547]", "tRNA-guanine(15) transglycosylase-like [IPR002616]", "tRNase Z endonuclease [IPR027794]", "v-SNARE, coiled-coil homology domain [IPR042855]", "von Willebrand factor, type A [IPR002035]"], "available_proteins": ["AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN4", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADSL", "AFDN", "AFG3L2", "AGFG1", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK2", "AK4", "AKAP1", "AKAP12", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG1", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANLN", "ANO6", "ANP32B", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APC", "APEH", "APEX1", "APMAP", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARHGAP17", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID4B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6", "ARL8B", "ARMCX3", "ARMT1", "ASAH1", "ASCC1", "ASCC2", "ASCC3", "ASH2L", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATG13", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "ATP6V1H", "ATP7A", "ATP7B", "ATXN10", "ATXN2", "ATXN2L", "AUP1", "AURKA", "BAG2", "BAG5", "BAG6", "BAIAP2", "BAZ1A", "BAZ1B", "BCAP31", "BCKDK", "BCL10", "BCS1L", "BEND3", "BIRC6", "BLVRA", "BLVRB", "BMS1", "BOP1", "BPHL", "BRAP", "BRCA1", "BRD1", "BRD2", "BRD3", "BRD4", "BRD7", "BRIX1", "BSG", "BTF3", "BUB1B", "BUD23", "BZW1", "BZW2", "C1orf35", "C2CD5", "CACYBP", "CAD", "CALCOCO1", "CALU", "CAMK2D", "CAMK2G", "CAMSAP3", "CAND1", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CBX1", "CBX3", "CBX5", "CC2D1A", "CCAR1", "CCAR2", "CCDC93", "CCNB1", "CCNK", "CCZ1B", "CD276", "CD2AP", "CD2BP2", "CD47", "CDC23", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDK1", "CDK12", "CDK16", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK5RAP2", "CDK7", "CDK9", "CDKAL1", "CDKN2AIP", "CEBPZ", "CELF1", "CELF2", "CENPV", "CEP170", "CEP290", "CEP44", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHD1", "CHD1L", "CHD4", "CHD8", "CHEK2", "CHERP", "CHID1", "CHORDC1", "CHP1", "CHRAC1", "CIAPIN1", "CIRBP", "CISD1", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP2", "CLCN3", "CLIC1", "CLIC4", "CLINT1", "CLPB", "CLPX", "CLTC", "CLUH", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT3", "CNPY2", "COA3", "COASY", "COG4", "COIL", "COLEC12", "COMMD1", "COMMD4", "COMMD7", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "COQ8A", "CORO1C", "COTL1", "COX2", "COX6C", "CPD", "CPNE1", "CPNE3", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRK", "CRKL", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK1E", "CSNK2A2", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNBL1", "CTPS1", "CTPS2", "CTSC", "CTTN", "CTTNBP2NL", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUL7", "CWF19L1", "CXADR", "CYB5B", "CYB5R1", "CYB5R3", "CYFIP1", "CYFIP2", "DAG1", "DAGLB", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCP1B", "DCTN1", "DCUN1D5", "DDB1", "DDI2", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DFFA", "DGCR8", "DHCR24", "DHFR", "DHODH", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNTTIP2", "DOCK1", "DOCK7", "DOLPP1", "DPF2", "DPM1", "DPP9", "DPYSL2", "DR1", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUS2", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC2H1", "EARS2", "ECE1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFHD2", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHHADH", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B3", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP3", "EMC1", "EMC7", "EMC8", "EMD", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERLIN1", "ERLIN2", "ERMP1", "ERP29", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC4", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM129B", "FAM208A", "FAM208B", "FAM210A", "FAM3C", "FAM49B", "FANCI", "FAR1", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD2", "FBXO22", "FBXO7", "FDFT1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FNBP1", "FNBP4", "FNDC3A", "FOXK1", "FOXK2", "FOXRED1", "FSCN1", "FTL", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCN1", "GDAP1", "GDE1", "GDPD1", "GEMIN5", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GIPC1", "GLA", "GLB1", "GLDC", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLTP", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPS", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGB1", "GORASP2", "GOT1", "GOT2", "GPAT4", "GPATCH4", "GPATCH8", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR89B", "GPRASP2", "GPS1", "GPT2", "GRB2", "GRHPR", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2H4", "GTF3C1", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAT1", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDLBP", "HEATR1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCR", "HMGCS1", "HMGXB4", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA4", "HSPA4L", "HSPB1", "HSPBP1", "HSPH1", "HTATSF1", "HTRA2", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKG", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMP3", "IMPDH1", "IMPDH2", "INA", "INCENP", "INF2", "INPP4A", "INTS1", "INTS11", "INTS12", "INTS14", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "IRF2BPL", "IRGQ", "IRS4", "ISCU", "ISOC1", "ISYNA1", "ITGAV", "ITGB1", "ITPRIP", "IVD", "IWS1", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0391", "KIAA1468", "KIF11", "KIF14", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIN", "KNOP1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMB1", "LAMTOR2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LCLAT1", "LDB1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC47", "LRRC8C", "LSM12", "LSM14B", "LSM2", "LSM4", "LSM6", "LSS", "LTA4H", "LYAR", "LYPLA1", "LYPLA2", "LYRM2", "LZIC", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAK16", "MAN2A1", "MANF", "MAP2K1", "MAP2K2", "MAP3K7", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARK2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MCAT", "MCCC1", "MCCC2", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MEPCE", "METAP2", "METTL13", "MFAP1", "MFF", "MFN2", "MFSD10", "MFSD8", "MGME1", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIEF1", "MINDY3", "MIPEP", "MKI67", "MLEC", "MMAB", "MMS19", "MOGS", "MORC2", "MORF4L1", "MOSPD2", "MOV10", "MPP1", "MPP2", "MPP6", "MPRIP", "MPST", "MRC2", "MRE11", "MRPL11", "MRPL12", "MRPL15", "MRPL2", "MRPL39", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL48", "MRPL58", "MRPL9", "MRPS23", "MRPS25", "MRPS35", "MRPS5", "MRPS7", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MUT", "MVD", "MYCBP2", "MYEF2", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA40", "NAA50", "NAE1", "NAGLU", "NAMPT", "NANS", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCBP1", "NCKIPSD", "NCL", "NCLN", "NCOR1", "NCSTN", "ND5", "NDUFA10", "NDUFA2", "NDUFA8", "NDUFA9", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFE", "NEMF", "NENF", "NES", "NF1", "NFATC2IP", "NFRKB", "NFS1", "NFXL1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP2", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRP1", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NTPCR", "NUB1", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDCD2", "NUDCD3", "NUDT1", "NUDT19", "NUDT21", "NUDT5", "NUDT9", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP35", "NUP50", "NUP54", "NUP62", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OMA1", "OPA1", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP2", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARL", "PARN", "PARP1", "PARP2", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCM1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDXK", "PEF1", "PELP1", "PEPD", "PES1", "PEX1", "PEX14", "PFAS", "PFKL", "PFKM", "PFKP", "PGD", "PGLS", "PGM1", "PGM2", "PGM3", "PGRMC1", "PHAX", "PHB", "PHB2", "PHC2", "PHF10", "PHF3", "PHF6", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PICALM", "PIGG", "PIH1D1", "PIK3C2A", "PIK3R2", "PIN4", "PINX1", "PIP4K2C", "PIR", "PITHD1", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLAA", "PLCG1", "PLD3", "PLD6", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLE4", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3C", "POLR3E", "POLRMT", "POP1", "POR", "PPAN", "PPAT", "PPFIA1", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R9B", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PQBP1", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PRELID3B", "PREP", "PREPL", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSPC1", "PTBP1", "PTBP2", "PTCD1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPN1", "PTPN11", "PTPRF", "PUF60", "PUM1", "PUM3", "PUS1", "PUS7", "PWP2", "PYCR1", "PYCR2", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RABGEF1", "RABGGTA", "RAC1", "RACGAP1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RALA", "RALGAPB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANGAP1", "RAP2B", "RAPGEF2", "RARS", "RASA1", "RAVER1", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM47", "RBM5", "RBM6", "RBM7", "RBM8A", "RBMX", "RBPJ", "RCL1", "RCN1", "RCN2", "RDX", "RECQL", "REPS1", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT2", "RIF1", "RIOK2", "RIPK1", "RMND1", "RNASEH2A", "RNF2", "RNF20", "RNF219", "RNF40", "RNMT", "RNPEP", "RNPS1", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL11", "RPL12", "RPL14", "RPL18", "RPL18A", "RPL19", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL30", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS2", "RPS20", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS9", "RPSA", "RPUSD3", "RRAS2", "RRBP1", "RRM1", "RRP12", "RRP7A", "RSF1", "RTCA", "RTF1", "RTFDC1", "RTN1", "RTN2", "RTN3", "RTN4", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAR1A", "SARNP", "SARS", "SARS2", "SART3", "SBDS", "SBNO1", "SC5D", "SCAF11", "SCAF4", "SCAP", "SCCPDH", "SCML2", "SCO2", "SCP2", "SCRIB", "SCYL2", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC63", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB1", "SERPINB6", "SERPINH1", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHCBP1", "SHMT1", "SHMT2", "SIN3A", "SIN3B", "SIRT1", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A9", "SLC16A1", "SLC25A12", "SLC25A13", "SLC25A24", "SLC27A4", "SLC2A1", "SLC2A8", "SLC38A1", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC7A1", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMG5", "SMN1*", "SMNDC1", "SMS", "SMU1", "SNAP23", "SNAP29", "SND1", "SNIP1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX2", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC25", "SPECC1L", "SPEN", "SPRYD7", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRFBP1", "SRI", "SRM", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK26", "STK38", "STK4", "STOML2", "STRBP", "STRIP1", "STRN", "STUB1", "STX10", "STX12", "STX18", "STX4", "STX5", "STX6", "STX7", "STX8", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUMF2", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE1", "SYNE2", "SYNGR2", "SYNJ2BP", "TAB1", "TACC3", "TAF15", "TAF6L", "TAGLN2", "TARDBP", "TARS", "TARS2", "TARSL2", "TAX1BP1", "TBC1D10A", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCB", "TBCD", "TBCE", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TDP2", "TECR", "TELO2", "TERF2IP", "TES", "TEX10", "TFAM", "TFB1M", "TFCP2", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOP1", "THTPA", "THUMPD1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIMELESS", "TIMM13", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TKFC", "TKT", "TLCD1", "TLN1", "TLN2", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM201", "TMEM205", "TMEM97", "TMF1", "TMLHE", "TMPO", "TMPO", "TMPPE", "TMTC3", "TMX1", "TMX2", "TMX4", "TNKS1BP1", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOM1", "TOP1", "TOP2A", "TOP2B", "TP53", "TP53BP1", "TPBG", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRIM13", "TRIM21", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIO", "TRIP10", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TROVE2", "TRRAP", "TRUB1", "TSC2", "TSFM", "TSG101", "TSR1", "TSR3", "TTC4", "TTC7B", "TTF2", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBG1", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TWNK", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", 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overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +P-type ATPase [IPR001757] 7 8 2.7360476652840746 0.0062182018272194 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 1.387816695443604e-05 1.0 1.0 0.0152248647419399 5.100313122590283e-06 +Mitochondrial carrier protein [IPR002067] 9 11 2.395193234924033 0.0166116081152698 5.686893203883495 11.07766990291262 0.8032246115450145 0.31892620527414 3.2338505495684404 1.5403272908315857 1.3918146051602212 0.3274613788058813 0.0068595428648402 1.0 1.0 1.0 0.00223229240551 +Beta tubulin [IPR002453] 5 6 2.217143950031643 0.0266132563012388 3.5533980582524274 5.54126213592233 0.5823511994709325 0.3808337519133083 1.5578062452886454 0.9632803779920796 1.1906256051626651 0.3058955364405814 1.0025096548661049e-05 1.0 1.0 0.1973959389561772 2.8311070051942505e-05 +Tubulin [IPR000217] 5 7 2.0895229346523223 0.0366606756361753 3.6140776699029127 5.883495145631068 0.537603280896448 0.3771225437200781 1.6631634011190108 1.117390952728082 1.2199662970774952 0.3090115161057067 0.000508394757649 1.0 1.0 0.3559534457378639 0.0013369974246366 +Transmembrane emp24 domain-containing protein [IPR015720] 5 6 2.0298944380450106 0.0423672705758955 2.6432038834951457 5.099514563106796 0.3626508447128717 0.2724944971681708 1.287119696753696 0.8431907483703972 1.4713835809049645 0.2794327521776852 0.0028961418368086 1.0 1.0 0.0147480216610697 0.0003286021100258 +Syntaxin [IPR045242] 6 7 1.9975462087608609 0.0457658799847124 2.674757281553398 5.815533980582524 0.7134969984167514 0.3462495636510407 1.4434464182805606 1.4295601388514203 1.142372356309129 0.3001529293380739 0.1024144220510148 1.0 0.1265462710440741 0.0435926191526008 0.0277461310389573 +Short-chain dehydrogenase/reductase SDR [IPR002347] 5 17 1.976948335843752 0.0480474703627842 5.718446601941747 18.0995145631068 0.008772682461134 0.4543214138763476 3.0550530344439446 1.989608869519688 1.0849187974128112 0.2985111477910666 0.0086872632138223 1.0 0.2732850813359189 0.1887844423268079 0.0045924061823516 diff --git a/interpro_family/metrics.json b/interpro_family/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..54a3cbbbc90c04d585316e2702d4c230114fbb7f --- /dev/null +++ b/interpro_family/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3120, + "annotations_size": 2421, + "title": "Average number of proteins per term", + "value": 1.2833539859562164 +} \ No newline at end of file diff --git a/interpro_family/paths.json b/interpro_family/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..30c1ba0784210331b17b3f209dcd404ad260f8f4 --- /dev/null +++ b/interpro_family/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_family/fragment/C390/C390_val_log2fc"} \ No newline at end of file diff --git a/interpro_family/result.tsv b/interpro_family/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..0d41f866694c08a3b2796159bcdcac2c0ae53ab9 --- /dev/null +++ b/interpro_family/result.tsv @@ -0,0 +1,121 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +P-type ATPase [IPR001757] 0.8631105398457536 2.7360476652840746 0.0062182018272194 0.9999997235585512 0.2046111419325319 8 P16615,P98194,P20020,P05023,Q04656,Q9HD20,P35670 7 +Mitochondrial carrier protein [IPR002067] 0.724082894023374 2.3951932349240335 0.0166116081152698 1.0 0.2046111419325319 11 P12236,P12235,Q6NUK1,Q9BQT8,O75746,Q9HC21,Q9UJS0,O43808,P05141 9 +Beta tubulin [IPR002453] 0.8188824662813031 2.217143950031643 0.0266132563012388 1.0 0.2046111419325319 6 Q13885,Q9BVA1,P07437,Q9BUF5,P68371 5 +Eukaryotic porin/Tom40 [IPR027246] 0.9058151096950652 2.128696365717083 0.0332793897230625 1.0 0.205696546142816 4 P21796,Q9Y277 2 +Tubulin [IPR000217] 0.7644139892546106 2.0895229346523223 0.0366606756361753 1.0 0.2067344785293815 7 Q13885,Q9BVA1,P07437,Q9BUF5,P68371 5 +Transmembrane emp24 domain-containing protein [IPR015720] 0.7774566473988342 2.0298944380450106 0.0423672705758955 1.0 0.2173965502365605 6 Q15363,Q9BVK6,Q9Y3B3,P49755,Q9Y3A6 5 +Syntaxin [IPR045242] 0.7449405717956795 1.9975462087608609 0.0457658799847124 1.0 0.2217320223225297 7 O15400,Q86Y82,O60499,O43752,Q12846,Q13190 6 +Short-chain dehydrogenase/reductase SDR [IPR002347] 0.5692199742495336 1.976948335843752 0.0480474703627842 1.0 0.2236057262860579 17 Q9Y394,Q3SXM5,Q8NBN7,Q9BY49,Q53GQ0 5 +Nucleosome assembly protein (NAP) [IPR002164] 0.8333649540570884 1.8282713808478468 0.0675088327698043 1.0 0.2487654248640735 4 Q01105,Q99733 2 +Porin, eukaryotic type [IPR001925] 0.9865255052935508 1.7821946048425896 0.0747175023142978 1.0 0.2580143477668793 3 P21796,Q9Y277 2 +Histidine phosphatase superfamily, clade-2 [IPR000560] 0.98637847391115 1.7816262474635394 0.0748102012232232 1.0 0.2580143477668793 3 Q9NPH0 1 +Nucleobindin [IPR040250] 0.9874919820397692 1.746234376377055 0.0807702336745936 1.0 0.2657279829606269 2 P80303 1 +Tetraspanin/Peripherin [IPR018499] 0.985246953175112 1.7369545789164331 0.0823951884768312 1.0 0.2684774580113169 2 O60637 1 +Tetraspanin, animals [IPR000301] 0.985246953175112 1.7369545789164331 0.0823951884768312 1.0 0.2684774580113169 2 O60637 1 +Sulfotransferase [IPR005331] 0.9820397690827471 1.723692804558283 0.0847633146758246 1.0 0.2716914431525309 2 Q7LGA3 1 +Peptidase S10, serine carboxypeptidase [IPR001563] 0.9711260827718956 1.7225723835136637 0.0849658826709092 1.0 0.2716914431525309 3 Q9HB40,Q9H3G5 2 +Mitochondrial carrier UCP-like [IPR002030] 0.9737010904425948 1.6891869184276285 0.0911836151050586 1.0 0.282657531586872 2 Q9H2D1 1 +Palmitoyl protein thioesterase [IPR002472] 0.9688903143040436 1.669264547069232 0.0950649630423108 1.0 0.2866566230489269 2 P50897 1 +Cleft lip and palate transmembrane protein 1-like protein [IPR030434] 0.968248877485572 1.6666074657836425 0.0955924833956261 1.0 0.2871332534749513 2 Q96KA5 1 +Cleft lip and palate transmembrane 1 [IPR008429] 0.968248877485572 1.6666074657836425 0.0955924833956261 1.0 0.2871332534749513 2 Q96KA5 1 +CD36 family [IPR002159] 0.9679281590763342 1.6652788603445623 0.0958571340301026 1.0 0.2872154968897011 2 Q14108 1 +Cytochrome P450 [IPR001128] 0.9650416933932058 1.6533195227553723 0.0982658517841232 1.0 0.2905778488187296 2 Q6UW02 1 +Transmembrane protein GPR107/GPR108-like [IPR009637] 0.964079538165496 1.64933234562145 0.0990795665507457 1.0 0.291552997792963 2 Q8NBN3 1 +Haem oxygenase [IPR002051] 0.9637588197562574 1.6480032080369134 0.0993520128786429 1.0 0.291552997792963 2 P30519 1 +Haem oxygenase-like [IPR016053] 0.9637588197562574 1.6480032080369134 0.0993520128786429 1.0 0.291552997792963 2 P30519 1 +V-type ATPase, V0 complex, 116kDa subunit family [IPR002490] 0.9586273252084688 1.626731955292978 0.1037940388096883 1.0 0.2989163379056743 2 Q93050 1 +ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028] 0.9586273252084688 1.626731955292978 0.1037940388096883 1.0 0.2989163379056743 2 Q93050 1 +Acyltransferase ChoActase/COT/CPT [IPR000542] 0.949326491340603 1.5881568732825069 0.112250870429079 1.0 0.3122203615326867 2 P23786 1 +Proteasome B-type subunit [IPR023333] 0.6538582434633117 1.5550993263665784 0.1199224153804408 1.0 0.3213649681742741 7 P28074 1 +Type 1 protein exporter [IPR039421] 0.9387427838357932 1.544237510574375 0.1225308047565727 1.0 0.3245591666473333 2 O75027 1 +MICOS complex subunit MIC26/MIC27 [IPR019166] 0.937780628608082 1.540244025419943 0.1235008821652261 1.0 0.3257033068867238 2 Q9BUR5 1 +MICOS complex subunit MIC26/MIC27, animal [IPR033182] 0.937780628608082 1.540244025419943 0.1235008821652261 1.0 0.3257033068867238 2 Q9BUR5 1 +Yif1 family [IPR005578] 0.9310455420141112 1.5122876782599552 0.1304606942706916 1.0 0.3363635152602177 2 Q5BJH7 1 +Transmembrane protein 126 [IPR009801] 0.9288005131494624 1.5029685462628457 0.1328471551913157 1.0 0.3392647286056702 2 Q9H061 1 +Bcl-2 family [IPR026298] 0.9246311738293778 1.4856618615889672 0.1373685832877489 1.0 0.3453471860224716 2 Q07820 1 +Bcl2-like [IPR002475] 0.9246311738293778 1.4856618615889672 0.1373685832877489 1.0 0.3453471860224716 2 Q07820 1 +Synthesis of cytochrome c oxidase, Sco1/Sco2 [IPR017276] 0.911481719050673 1.431091444395131 0.152404008992129 1.0 0.3655079978906889 2 O43819 1 +Copper chaperone SCO1/SenC [IPR003782] 0.911481719050673 1.431091444395131 0.152404008992129 1.0 0.3655079978906889 2 O43819 1 +Lysosome-associated membrane glycoprotein [IPR002000] 0.9111610006414366 1.4297608656439509 0.1527856645457981 1.0 0.3655079978906889 2 P13473 1 +ATPase family AAA domain-containing protein 3 [IPR039188] 0.9095574085952532 1.4231083739082355 0.1547047412260829 1.0 0.3678049435360319 2 Q9NVI7 1 +Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930] 0.6702116377227508 1.4079887549565422 0.1591343997921734 1.0 0.3684520522163166 5 P55786,Q9UIQ6,Q9NZ08 3 +Glycoside hydrolase, family 29 [IPR000933] 0.9047466324567028 1.4031554358688756 0.1605704932530476 1.0 0.3705607699873114 2 P04066 1 +Alpha-L-fucosidase, metazoa-type [IPR016286] 0.9047466324567028 1.4031554358688756 0.1605704932530476 1.0 0.3705607699873114 2 P04066 1 +Aminopeptidase N-type [IPR034016] 0.8857876162977171 1.389661445379369 0.1646317075850432 1.0 0.3763676714479599 3 P55786,Q9UIQ6 2 +Mpv17/PMP22 [IPR007248] 0.8976908274535107 1.3739063200456034 0.1694707673243041 1.0 0.3832731768330563 2 Q567V2 1 +SCAMP [IPR007273] 0.7245203106914826 1.3637978926228138 0.1726311837432648 1.0 0.3876995323213767 4 O15127,O14828 2 +GPI mannosyltransferase [IPR005599] 0.8838999358563189 1.316809647622584 0.1879024381712566 1.0 0.4087257886905771 2 Q9BV10 1 +P-type ATPase, subfamily IB [IPR027256] 0.8726747915330345 1.2704320630502226 0.2039307681959257 1.0 0.4282015523003782 2 P35670 1 +Erlin1/2 [IPR033294] 0.8643361128928804 1.2360531873253449 0.2164387940170404 1.0 0.4428459667375453 2 O94905 1 +P-type ATPase, subfamily IIB [IPR006408] 0.8614496472097508 1.2241697478436695 0.2208881988693567 1.0 0.4474125665522132 2 P20020 1 +TB2/DP1/HVA22-related protein [IPR004345] 0.8579217447081462 1.2096585470649046 0.2264099423815304 1.0 0.4545095111987439 2 Q00765 1 +Tumour protein D52 [IPR007327] 0.8399615137908916 1.1360401610500408 0.2559397566306907 1.0 0.4890529998444374 2 P55327 1 +SUN domain-containing protein 1-5 [IPR045119] 0.8322642719692112 1.1046436110732898 0.2693140461167997 1.0 0.5050420647937818 2 Q9UH99 1 +Nonaspanin (TM9SF) [IPR004240] 0.8036573628488787 1.0694970014961356 0.2848457792624961 1.0 0.5206627636071605 3 Q9HD45,Q99805 2 +Prohibitin [IPR000163] 0.8229634381013664 1.0668529177705697 0.2860382583464584 1.0 0.5214598068198614 2 Q99623 1 +Prenylated rab acceptor PRA1 [IPR004895] 0.7965992941931304 1.0422622234504757 0.29729012149314 1.0 0.5319180543966245 3 Q9UI14,O60831 2 +A-kinase anchoring protein 95 (AKAP95) [IPR007071] 0.7939669385472305 1.032123997302596 0.3020140333731704 1.0 0.5359093488460049 3 Q9ULX6 1 +TAF15/EWS/TLS family [IPR034870] 0.7863330125120237 1.0027870877983436 0.3159636001470787 1.0 0.5483375905888761 3 P35637,Q92804 2 +Beta-hexosaminidase [IPR025705] 0.8053239255933463 0.9956984460629288 0.3193966853674606 1.0 0.5515402106095735 2 P06865 1 +Tricarboxylate/iron carrier [IPR004686] 0.780558229066408 0.9806634825011972 0.326758717574898 1.0 0.5571006022879071 3 Q6P4A7,Q9H9B4 2 +Anoctamin [IPR007632] 0.7979474021809033 0.9661753942475466 0.3339564231067666 1.0 0.5628853867840538 2 Q9NW15 1 +Calcium uptake protein 1/2/3 [IPR039800] 0.7957023733162354 0.957220436576764 0.3384560040317601 1.0 0.564622565705252 2 Q9BPX6 1 +Polyprenyl synthetase [IPR000092] 0.7717397944210005 0.9470059451443734 0.3436357494993149 1.0 0.569823390094412 3 O95749 1 +ADP/ATP carrier protein, eukaryotic type [IPR002113] 0.7667629130574232 0.9280841320201298 0.3533639300257807 1.0 0.5783355719496764 3 P12236,P12235 2 +Peptidase, FtsH [IPR005936] 0.7873636946760736 0.9240918947173076 0.3554384729456581 1.0 0.5798628995966565 2 Q9Y4W6 1 +Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein [IPR001129] 0.7677998717126349 0.8472856434255989 0.3968359268355486 1.0 0.6150702809659816 2 Q99735 1 +Mini-chromosome maintenance protein [IPR031327] 0.5255185569075023 0.8265316911399233 0.4085025484606701 1.0 0.6239650913711561 6 Q14566 1 +Peptidase T1A, proteasome beta-subunit [IPR000243] 0.7384942874714464 0.8218089530834357 0.4111856373929312 1.0 0.626482333623843 3 P28074 1 +Sodium/potassium-transporting ATPase subunit beta [IPR000402] 0.7584990378447709 0.8112855707981952 0.4172016943837082 1.0 0.6316731095077909 2 P05026 1 +Vacuolar protein sorting-associated protein 13 [IPR026847] 0.7543296985246934 0.7952675606454707 0.4264578792109048 1.0 0.6377112573005563 2 Q709C8 1 +Ancient conserved domain protein family [IPR045095] 0.7456703014753088 0.7622539580604624 0.4459084475806301 1.0 0.6547562874607693 2 Q6P4Q7 1 +Prefoldin beta-like [IPR002777] 0.7168081202373366 0.7419858802720349 0.4580958904975301 1.0 0.6648981719991128 3 O15212 1 +Torsin-1A-interacting protein 1/2 [IPR008662] 0.7395766516998055 0.7392405865800653 0.4597609195723933 1.0 0.665320493894061 2 Q5JTV8 1 +Flotillin family [IPR027705] 0.7389352148813322 0.7368291194637256 0.4612262725285374 1.0 0.6670422973665406 2 O75955 1 +PDK/BCKDK protein kinase [IPR039028] 0.710619185113891 0.7195343396595459 0.4718117518621465 1.0 0.6731032712187723 3 Q15118,Q15120 2 +Proteasome activator PA28 [IPR009077] 0.7086942572986783 0.7125840507061497 0.4761031840298393 1.0 0.6764353336480288 3 P61289,Q9UL46 2 +THRAP3/BCLAF1 family [IPR029199] 0.7309172546504146 0.7068703158753725 0.479647072388397 1.0 0.678418841932455 2 Q9Y2W1 1 +Paraneoplastic antigen Ma [IPR026523] 0.727710070558055 0.6949858241128113 0.4870641854850863 1.0 0.6827923526690179 2 Q9H0W5 1 +Heterogeneous nuclear ribonucleoprotein C [IPR017347] 0.7273893521488126 0.6938005909145409 0.487807272001332 1.0 0.6830430338433919 2 P07910 1 +Synaptobrevin [IPR001388] 0.723220012828734 0.6784469307382635 0.4974883613894683 1.0 0.6917974284456649 2 O75396 1 +Peroxisomal acyl-coenzyme A oxidase [IPR034171] 0.7180885182809715 0.6596924841978095 0.5094511907471833 1.0 0.7011832477537979 2 Q15067 1 +Acyl-CoA oxidase [IPR012258] 0.7180885182809715 0.6596924841978095 0.5094511907471833 1.0 0.7011832477537979 2 Q15067 1 +Hexokinase [IPR001312] 0.7174470814625031 0.6573595275132368 0.5109497688022031 1.0 0.7016670684662081 2 P52789 1 +Torsin [IPR010448] 0.7126363053239532 0.639945061543133 0.5222083168519744 1.0 0.7090669293879025 2 O14657 1 +Torsin 1/2 [IPR017378] 0.7126363053239532 0.639945061543133 0.5222083168519744 1.0 0.7090669293879025 2 O14657 1 +HnRNP R/Q splicing factor [IPR006535] 0.6779670894829048 0.6040112702911307 0.5458361491854054 1.0 0.7232450241752089 3 O60506 1 +Tropomyosin [IPR000533] 0.6734039140198873 0.5883118740150367 0.5563229769966396 1.0 0.7278631257204974 3 P67936,P09493 2 +Major facilitator superfamily [IPR011701] 0.6477382098171327 0.502419187694417 0.615372684710191 1.0 0.7651860655795442 3 Q8NHS3,Q14728 2 +Microtubule-associated protein RP/EB [IPR027328] 0.6703014753046788 0.4938208777722779 0.6214326872003304 1.0 0.7696628351764406 2 Q15555 1 +Proteasome, subunit alpha/beta [IPR001353] 0.3702161910003845 0.4651675431689577 0.6418114798132524 1.0 0.7808168807175296 14 P28074 1 +SLC12A transporter family [IPR004842] 0.6587556125721588 0.4565168720772241 0.6480183409932256 1.0 0.7825431428893463 2 P55011 1 +14-3-3 protein [IPR000308] 0.4457289659601848 0.4561499034339971 0.6482821868260846 1.0 0.7825431428893463 6 P62258,Q04917,P31946,P61981,P63104 5 +Fragile X mental retardation syndrome-related protein [IPR040148] 0.6456061577934531 0.4155609196597404 0.6777313286260527 1.0 0.798825485201399 2 P51116 1 +KH domain-containing BBP-like [IPR045071] 0.602109766443371 0.3618643149206672 0.7174534278777618 1.0 0.8179823395489105 3 Q07666 1 +Dynein 1 light intermediate chain [IPR008467] 0.6161000641436817 0.3301965720116074 0.7412514368590819 1.0 0.8288511695320439 2 Q9Y6G9 1 +Dynein family light intermediate chain [IPR022780] 0.6161000641436817 0.3301965720116074 0.7412514368590819 1.0 0.8288511695320439 2 Q9Y6G9 1 +Small GTPase, Ras-type [IPR020849] 0.4560333761232399 0.2860346796134276 0.7748515601898647 1.0 0.8422700191537902 4 P11233,P61225,P62070 3 +E3 ubiquitin ligase Bre1 [IPR013956] 0.585311096856966 0.251872845932843 0.801139348872423 1.0 0.8548075643984734 2 O75150 1 +Guanine nucleotide binding protein (G-protein), alpha subunit [IPR001019] 0.3996789727126849 0.2281850754300285 0.8195023634863821 1.0 0.8656261876093067 5 P04899,Q14344,P09471,P63096 4 +Paraneoplastic encephalomyelitis antigen [IPR002343] 0.5663887107119887 0.2096781010359291 0.8339189184348761 1.0 0.8745004858702333 2 Q15717 1 +YTH domain containing protein [IPR045168] 0.5580500320718353 0.1925798459558121 0.8472880300548071 1.0 0.8830324239185054 2 Q96MU7 1 +Adenylate kinase subfamily [IPR006259] 0.5522771007055741 0.1812858647944552 0.8561432004630964 1.0 0.8867830176036389 2 P27144 1 +H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 [IPR007504] 0.5493906350224439 0.1758061711288388 0.8604462212937736 1.0 0.8894706668455277 2 Q96HR8 1 +Exosome complex RNA-binding protein 1/RRP40/RRP4 [IPR026699] 0.5455420141116034 0.1686736313493046 0.8660533607018368 1.0 0.8933596873707487 2 Q9NQT5 1 +Heat shock protein Hsp90 family [IPR001404] 0.4082156611039822 0.1525943600492813 0.8787181729390967 1.0 0.8999055400531104 4 P07900,P14625,Q12931 3 +Transport protein particle (TRAPP) component [IPR007194] 0.5314304041051887 0.1442180463396917 0.8853282909955575 1.0 0.906291667019131 2 Q8IUR0 1 +cAMP-dependent protein kinase regulatory subunit [IPR012198] 0.5311096856959532 0.1436931392035492 0.8857427890965717 1.0 0.9063327524948436 2 P13861 1 +G-protein alpha subunit, group I [IPR001408] 0.3995507060333821 0.1320864560372428 0.8949159085621856 1.0 0.9146801860879328 4 P04899,P09471,P63096 3 +Vacuolar protein sorting protein 26 related [IPR028934] 0.5070558050032016 0.1081782476017425 0.9138542995818412 1.0 0.9319466130107994 2 Q4G0F5 1 +Clathrin light chain [IPR000996] 0.5044900577293104 0.1048309760998132 0.9165099300914265 1.0 0.934261280316355 2 P09496 1 +Protein transport protein Sec23 [IPR037364] 0.5003207184092308 0.0995682544846086 0.920687097799154 1.0 0.9373353506189032 2 Q15436 1 +Cell cycle and apoptosis regulator protein [IPR025224] 0.470493906350219 0.0680145762601414 0.9457740309766844 1.0 0.9588437726107844 2 Q8N163 1 +Peptidase M3A/M3B [IPR045090] 0.4581328200192496 0.0635966393329192 0.9492914077509058 1.0 0.9620069058873768 3 Q9BYT8,Q99797 2 +Gamma-tubulin complex component protein [IPR007259] 0.412764592687614 0.0326059623547174 0.9739888150886178 1.0 0.9829207675404518 2 Q9BSJ2 1 +Vacuolar protein sorting-associated protein 9-like [IPR045046] 0.3835792174470755 0.0240137346349209 0.9808416532122308 1.0 0.988661585686079 2 Q14C86 1 +CPSF6/7 family [IPR034772] 0.361770365618984 0.0202041667550609 0.9838805039752014 1.0 0.991250395390746 2 Q8N684 1 +Nuclear pore complex protein [IPR026054] 0.3550352790250094 0.019360513885234 0.9845535098544808 1.0 0.9915158266878944 2 P35658 1 +Acidic leucine-rich nuclear phosphoprotein 32 [IPR045081] 0.3438101347017283 0.0182295307204871 0.9854557444395332 1.0 0.991614995859962 2 Q92688 1 +Copine [IPR045052] 0.2838357921744662 0.015730949485784 0.9874490359300508 1.0 0.9931924038166402 2 O75131 1 +Chaperone DnaJ [IPR012724] 0.3808148861084363 0.002408651190108 0.9980781762613292 1.0 1.0 3 Q96EY1,O60884 2 diff --git a/interpro_family/selections.json b/interpro_family/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f8a7453fc6989f013974e34d9bd383ef22f5c6c2 --- /dev/null +++ b/interpro_family/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["(Uracil-5)-methyltransferase family [IPR010280]", "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, eukaryotes [IPR027496]", "1-Cys peroxiredoxin [IPR045020]", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [IPR028380]", "14-3-3 protein [IPR000308]", "14-3-3 theta [IPR042584]", "14kDa phosphohistidine phosphatase [IPR028441]", "16S/18S rRNA aminocarboxypropyltransferase Tsr3 [IPR022968]", "18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23-like [IPR039769]", "2-amino-3-ketobutyrate coenzyme A ligase [IPR011282]", "2-deoxynucleoside 5-phosphate N-hydrolase 1, DNPH1 [IPR028607]", "2-oxoglutarate dehydrogenase E1 component [IPR011603]", "2-phosphoglycolate phosphatase, eukaryotic [IPR006349]", "26S Proteasome non-ATPase regulatory subunit 1 [IPR035266]", "26S Proteasome non-ATPase regulatory subunit 11 [IPR035295]", "26S Proteasome non-ATPase regulatory subunit 12 [IPR035297]", "26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4 [IPR040134]", "26S Proteasome non-ATPase regulatory subunit 13 [IPR035298]", "26S Proteasome non-ATPase regulatory subunit 14 [IPR035299]", "26S Proteasome non-ATPase regulatory subunit 6 [IPR035268]", "26S Proteasome non-ATPase regulatory subunit 7/8 [IPR033858]", "26S Proteasome regulatory subunit 4 [IPR035244]", "26S Proteasome regulatory subunit 6A [IPR035254]", "26S Proteasome regulatory subunit 6B [IPR035256]", "26S Proteasome regulatory subunit 7 [IPR035245]", "26S proteasome non-ATPase regulatory subunit 10-like [IPR039334]", "26S proteasome non-ATPase regulatory subunit 3 [IPR035267]", "26S proteasome non-ATPase regulatory subunit Rpn12 [IPR006746]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit [IPR016643]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit [IPR016642]", "26S proteasome regulatory subunit 10B [IPR035263]", "26S proteasome regulatory subunit P45-like [IPR005937]", "26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 [IPR019585]", "28S ribosomal protein S17, mitochondrial [IPR039193]", "28S ribosomal protein S25, mitochondrial [IPR040049]", "28S ribosomal protein S26 [IPR026140]", "28S ribosomal protein S27, mitochondrial [IPR019266]", "28kDa heat- and acid-stable phosphoprotein [IPR039876]", "3-hydroxyacyl-CoA dehydrogenase [IPR022694]", "3-hydroxyisobutyrate dehydrogenase [IPR011548]", "3-hydroxyisobutyrate dehydrogenase-related [IPR015815]", "3-ketodihydrosphingosine reductase KDSR-like [IPR045022]", "3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase [IPR039357]", "3-oxoacid CoA-transferase [IPR014388]", "39S ribosomal protein L40, mitochondrial [IPR039145]", "39S ribosomal protein L43/54S ribosomal protein L51 [IPR039927]", "39S ribosomal protein L46, mitochondrial [IPR040008]", "40S Ribosomal protein S10 [IPR037447]", "40S ribosomal protein S1/3, eukaryotes [IPR027500]", "40S ribosomal protein SA [IPR027504]", "4F2 cell-surface antigen heavy chain [IPR042280]", "5'-3' exoribonuclease [IPR027073]", "5'-3' exoribonuclease type 2 [IPR017151]", "5'-AMP-activated protein kinase subunit gamma-1 [IPR039166]", "5-formyltetrahydrofolate cyclo-ligase [IPR002698]", "5-lipoxygenase-activating protein [IPR001446]", "50S ribosomal protein L18Ae/60S ribosomal protein L20 and L18a [IPR028877]", "50S ribosomal protein uL4 [IPR013005]", "6-Phosphogluconolactonase [IPR039104]", "6-phosphogluconate dehydrogenase [IPR006183]", "6-phosphogluconate dehydrogenase, decarboxylating [IPR006113]", "60S acidic ribosomal protein P0 [IPR030670]", "60S ribosomal protein L18a/ L20, eukaryotes [IPR021138]", "60S ribosomal protein L19 [IPR039547]", "60S ribosomal protein L35 [IPR045059]", "60S ribosomal protein L6E [IPR000915]", "60kDa SS-A/Ro ribonucleoprotein [IPR040322]", "A-kinase anchor protein 12 [IPR028540]", "A-kinase anchor protein 17A [IPR034355]", "A-kinase anchor protein 9/Pericentrin [IPR028745]", "A-kinase anchoring protein 95 (AKAP95) [IPR007071]", "A1 cistron-splicing factor, AAR2 [IPR007946]", "AAA ATPase, CDC48 family [IPR005938]", "ADF/Cofilin [IPR017904]", "ADP-ribose pyrophosphatase, mitochondrial [IPR039989]", "ADP-ribosylation factor 1-5 [IPR045872]", "ADP-ribosylation factor-like protein 10 [IPR042951]", "ADP-ribosylation factor-like protein 2 [IPR045873]", "ADP-ribosylation factor-like protein 2/3 [IPR044612]", "ADP-ribosylation factor-like protein 6 [IPR041839]", "ADP-ribosylation factor-like protein 6-interacting protein 1 [IPR033301]", "ADP-ribosylation factor-like protein 8A/8B [IPR044154]", "ADP-ribosylation/Crystallin J1 [IPR005502]", "ADP-specific phosphofructokinase/glucokinase [IPR007666]", "ADP/ATP carrier protein, eukaryotic type [IPR002113]", "AH receptor-interacting protein [IPR031208]", "AIP/AIPL1 [IPR039663]", "AP complex subunit beta [IPR026739]", "AP endonuclease 1 [IPR004808]", "AP-1/2/4 complex subunit beta [IPR016342]", "AP-2 complex subunit sigma [IPR027156]", "AP-3 complex subunit beta [IPR026740]", "ARMET-like [IPR045333]", "AT-rich interactive domain-containing protein 4B [IPR028853]", "ATP synthase membrane subunit K [IPR009125]", "ATP synthase, F0 complex, subunit A [IPR000568]", "ATP synthase, F0 complex, subunit A, bacterial/mitochondria [IPR045083]", "ATP synthase, F0 complex, subunit B [IPR013837]", "ATP synthase, F0 complex, subunit B/MI25 [IPR008688]", "ATP synthase, F0 complex, subunit D, mitochondrial [IPR008689]", "ATP synthase, F0 complex, subunit E, mitochondrial [IPR008386]", "ATP synthase, F0 complex, subunit G, mitochondrial [IPR006808]", "ATP synthase, F1 complex, alpha subunit [IPR005294]", "ATP synthase, F1 complex, beta subunit [IPR005722]", "ATP synthase, F1 complex, gamma subunit [IPR000131]", "ATP-citrate synthase [IPR014608]", "ATP-dependent 6-phosphofructokinase [IPR022953]", "ATP-dependent 6-phosphofructokinase, eukaryotic-type [IPR009161]", "ATP-dependent 6-phosphofructokinase, vertebrate-type [IPR041914]", "ATP-dependent Clp protease proteolytic subunit [IPR001907]", "ATP-dependent RNA helicase DHX29 [IPR034730]", "ATP-dependent RNA helicase Ski2-like [IPR016438]", "ATP11 [IPR010591]", "ATP:cob(I)alamin adenosyltransferase, PduO-type [IPR029499]", "ATP:guanido phosphotransferase [IPR000749]", "ATPase family AAA domain-containing protein 2 [IPR031252]", "ATPase family AAA domain-containing protein 3 [IPR039188]", "ATPase family AAA domain-containing protein ATAD2-like [IPR045199]", "ATPase, OSCP/delta subunit [IPR000711]", "ATPase, V0 complex, c/d subunit [IPR002843]", "ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028]", "ATPase, V0 complex, subunit d [IPR016727]", "ATPase, V1 complex, subunit A [IPR005725]", "ATPase, V1 complex, subunit B [IPR005723]", "ATPase, V1 complex, subunit C [IPR004907]", "ATPase, V1 complex, subunit H [IPR004908]", "Acid ceramidase-like [IPR016699]", "Acidic leucine-rich nuclear phosphoprotein 32 [IPR045081]", "Acireductone dioxygenase ARD family [IPR004313]", "Aconitase, mitochondrial-like [IPR006248]", "Aconitase/Iron-responsive element-binding protein 2 [IPR006249]", "Actin family [IPR004000]", "Actin-related protein 10 [IPR027127]", "Actin-related protein 2/3 complex subunit 1 [IPR017383]", "Actin-related protein 2/3 complex subunit 1A [IPR030140]", "Actin-related protein 2/3 complex subunit 1B [IPR030141]", "Actin-related protein 2/3 complex subunit 2 [IPR007188]", "Actin-related protein 2/3 complex subunit 3 [IPR007204]", "Actin-related protein 2/3 complex subunit 4 [IPR008384]", "Actin-related protein 2/3 complex subunit 5 [IPR006789]", "Actin-related protein 3 [IPR015623]", "Activating signal cointegrator 1 complex subunit 1 [IPR009210]", "Activating signal cointegrator 1-like [IPR039128]", "Activator of 90kDa heat shock protein ATPase-like [IPR039981]", "Activator of Hsp90 ATPase homologue 1-like [IPR013538]", "Active zone protein ELKS [IPR019323]", "Activity-dependent neuroprotector homeobox protein [IPR038861]", "Acyl-CoA desaturase [IPR015876]", "Acyl-CoA oxidase [IPR012258]", "Acyl-coenzyme A diphosphatase NUDT19 [IPR039121]", "Acyl-coenzyme A thioesterase 13 [IPR039298]", "Acylneuraminate cytidylyltransferase [IPR003329]", "Acyltransferase ChoActase/COT/CPT [IPR000542]", "Adaptor protein complex AP-1, gamma subunit [IPR017107]", "Adaptor protein complex AP-2, alpha subunit [IPR017104]", "Adaptor protein complex AP-3, delta subunit [IPR017105]", "Adaptor protein complex, sigma subunit [IPR016635]", "Adenine phosphoribosyl transferase [IPR005764]", "Adenomatous polyposis coli (APC) family [IPR026818]", "Adenomatous polyposis coli [IPR026836]", "Adenosine deaminase [IPR028893]", "Adenosine kinase [IPR001805]", "Adenosine/adenine deaminase [IPR006330]", "Adenosylhomocysteinase-like [IPR000043]", "Adenylate cyclase-associated CAP [IPR001837]", "Adenylate kinase 2 [IPR028587]", "Adenylate kinase 3/4, mitochondrial [IPR028586]", "Adenylate kinase 4, mitochondrial [IPR028585]", "Adenylate kinase isoenzyme 1 [IPR028582]", "Adenylate kinase subfamily [IPR006259]", "Adenylate kinase, isozyme 1/5 [IPR006267]", "Adenylate kinase/UMP-CMP kinase [IPR000850]", "Adenylosuccinate lyase [IPR004769]", "Adenylosuccinate synthetase [IPR001114]", "Adenylosuccinate synthetase isozyme 2, chordates [IPR027529]", "Adenylyl cyclase-associated protein CAP1 [IPR028415]", "Adenylyl-sulfate kinase [IPR002891]", "AdoMet-dependent rRNA methyltransferase Spb1-like [IPR028589]", "Aladin [IPR045139]", "Alanine-tRNA ligase, class IIc [IPR002318]", "Alanine-tRNA ligase, eukaryota/bacteria [IPR023033]", "Alcohol dehydrogenase class III [IPR014183]", "Aldehyde dehydrogenase NAD(P)-dependent [IPR012394]", "Aldehyde dehydrogenase family 7 member A1-like [IPR044638]", "Aldo-keto reductase [IPR020471]", "Aldo-keto reductase family 1 member A1 [IPR044481]", "Alkyldihydroxyacetonephosphate synthase [IPR025650]", "Alpha E-catenin/Alpha T-catenin [IPR030047]", "Alpha crystallin/Small heat shock protein, animal type [IPR001436]", "Alpha-1,2-mannosyltransferase ALG9-like [IPR039484]", "Alpha-2-macroglobulin receptor-associated protein [IPR038003]", "Alpha-D-phosphohexomutase superfamily [IPR005841]", "Alpha-L-fucosidase, metazoa-type [IPR016286]", "Alpha-N-acetylglucosaminidase [IPR007781]", "Alpha-adducin [IPR027766]", "Alpha-catenin [IPR001033]", "Alpha-internexin [IPR027703]", "Alpha-ketoglutarate-dependent dioxygenase FTO [IPR032868]", "Amidase [IPR000120]", "Amidophosphoribosyltransferase [IPR005854]", "Amino acid/polyamine transporter I [IPR002293]", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 [IPR042360]", "Aminoacyl-tRNA synthetase, class Ic [IPR002305]", "Aminopeptidase N-type [IPR034016]", "Aminopeptidase, leukotriene A4 hydrolase-like [IPR034015]", "Aminotransferase ALAT1/2-like [IPR045088]", "Aminotransferase class-III [IPR005814]", "Anamorsin [IPR007785]", "Anaphase-promoting complex subunit 1 [IPR024990]", "Anaphase-promoting complex subunit 16 [IPR029641]", "Anaphase-promoting complex subunit 2 [IPR044554]", "Anaphase-promoting complex subunit 4 [IPR024789]", "Anaphase-promoting complex subunit 4, metazoa [IPR017169]", "Anaphase-promoting complex subunit 5 [IPR037679]", "Ancient conserved domain protein family [IPR045095]", "Angiomotin [IPR009114]", "Ankycorbin [IPR042420]", "Ankyrin repeat and LEM domain-containing protein 2 [IPR035007]", "Ankyrin repeat domain-containing protein 13 [IPR021832]", "Annexin A1 [IPR002388]", "Annexin A11 [IPR008157]", "Annexin A2 [IPR002389]", "Annexin A3 [IPR002390]", "Annexin A4 [IPR002391]", "Annexin A6 [IPR002393]", "Annexin [IPR001464]", "Anoctamin [IPR007632]", "Anoctamin-10 [IPR031291]", "Anoctamin-6 [IPR031295]", "Antifreeze, type III [IPR006013]", "Apoptosis inhibitory 5 [IPR008383]", "Apoptosis regulator, Mcl-1 [IPR013281]", "Arfaptin family [IPR030798]", "Arfaptin-1 [IPR030793]", "Arginase [IPR014033]", "Arginine-tRNA ligase [IPR001278]", "Armadillo repeat-containing protein 6 [IPR040104]", "Arsenical pump ATPase, ArsA/GET3 [IPR016300]", "Arsenical pump ATPase, ArsA/GET3, eukaryotic [IPR027542]", "Arylesterase [IPR002640]", "Asparaginase-like 1, metazoa [IPR033844]", "Asparagine synthase, glutamine-hydrolyzing [IPR006426]", "Asparagine-tRNA ligase [IPR004522]", "Aspartate carbamoyltransferase [IPR002082]", "Aspartate-tRNA ligase, type 1 [IPR004524]", "Aspartate-tRNA synthetase, type 2 [IPR004523]", "Aspartate/ornithine carbamoyltransferase [IPR006130]", "Aspartate/other aminotransferase [IPR000796]", "Aspartyl/Asparaginyl-tRNA synthetase, class IIb [IPR002312]", "Aspartyl/asparaginyl beta-hydroxylase family [IPR039038]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit [IPR004413]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, subunit B /E [IPR017959]", "Associate of Myc 1 [IPR026060]", "Ataxin2 [IPR033093]", "Ataxin2-like [IPR045117]", "Atypical dual specificity phosphatase, subfamily A [IPR020405]", "Atypical kinase COQ8A [IPR034640]", "Aurora kinase [IPR030616]", "Autophagy protein Atg8 ubiquitin-like [IPR004241]", "Autophagy-related protein 13 [IPR040182]", "B-cell lymphoma/leukemia 10/E10 [IPR033238]", "B-cell receptor-associated protein 29/31 [IPR008417]", "BAG family molecular chaperone regulator 2 [IPR037689]", "BBP/SF1 family [IPR031150]", "BCP1 family [IPR025602]", "BEN domain-containing protein 3 [IPR033583]", "BLOC-2 complex, Hps6 subunit [IPR017218]", "BRCA1-A complex subunit BRE [IPR010358]", "BRCA1-associated ATM activator 1 [IPR038904]", "BRCA1-associated [IPR031099]", "Bacterial/eukaryotic lysine-tRNA ligase, class II [IPR034762]", "Baculoviral IAP repeat-containing protein 6 [IPR022103]", "Band 4.1 protein, chordates [IPR021187]", "Band 4.1-like protein 2 [IPR030546]", "Band 4.1-like protein 3 [IPR030691]", "Band 4.1-like protein 5 [IPR030694]", "Barrier- to-autointegration factor, BAF [IPR004122]", "Basigin [IPR044157]", "Basigin-like [IPR043204]", "Bax inhibitor 1-related [IPR006214]", "Bcl-2 family [IPR026298]", "Bcl-2-associated transcription factor 1 [IPR026668]", "Bcl-2-like protein 13 [IPR042398]", "Bcl2-like [IPR002475]", "Bet3 family [IPR016721]", "Beta tubulin [IPR002453]", "Beta-1,4-glucuronyltransferase 1 [IPR043189]", "Beta-N-acetylglucosaminidase [IPR011496]", "Beta-catenin [IPR013284]", "Beta-catenin-like protein 1 [IPR039678]", "Beta-galactosidase 1-like [IPR026283]", "Beta-hexosaminidase [IPR025705]", "Beta-lactamase HcpB-like [IPR040239]", "Bicarbonate transporter, eukaryotic [IPR003020]", "Bicaudal-D protein [IPR018477]", "Bifunctional purine biosynthesis protein PurH-like [IPR002695]", "Biliverdin reductase A [IPR017094]", "Biogenesis of lysosome-related organelles complex 1 subunit 1 [IPR009395]", "Biotin--acetyl-CoA-carboxylase ligase [IPR004408]", "BolA protein [IPR002634]", "BolA-like protein 2 [IPR045115]", "Brain acid soluble protein 1 [IPR008408]", "Breast cancer type 1 susceptibility protein (BRCA1) [IPR011364]", "Bud22/Serum response factor-binding protein 1 [IPR037393]", "Bystin [IPR007955]", "C-5 cytosine methyltransferase [IPR001525]", "C-terminal binding protein [IPR043322]", "C2 domain-containing protein 5 [IPR038983]", "CAAX prenyl protease 1 [IPR027057]", "CCR4-NOT complex, subunit 3/ 5 [IPR012270]", "CCR4-NOT transcription complex subunit 1 [IPR040398]", "CCR4-NOT transcription complex subunit 7 [IPR039636]", "CCR4-NOT transcription complex subunit 7/8/Pop2 [IPR039637]", "CCR4-NOT transcription complex subunit 9 [IPR007216]", "CD166 antigen [IPR039810]", "CD2 antigen cytoplasmic tail-binding protein 2/Lin1 [IPR039905]", "CD2-associated protein [IPR028445]", "CD36 family [IPR002159]", "CD36/scavenger receptor class B member 1 [IPR005428]", "CDGSH iron-sulfur domain-containing protein 1/2 [IPR045131]", "CDK5 regulatory subunit-associated protein 3 [IPR008491]", "CDP-alcohol phosphatidyltransferase [IPR000462]", "CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote [IPR014387]", "CEBPZ/Mak21-like [IPR040155]", "CGG triplet repeat-binding protein 1 [IPR033375]", "CHORD domain containing protein [IPR039790]", "CLU domain containing protein [IPR027523]", "COMM domain-containing protein 1 [IPR037351]", "COMM domain-containing protein 4 [IPR037356]", "COMM domain-containing protein 7 [IPR037358]", "COMPASS component Swd2/WDR82 [IPR037867]", "COP9 Signalosome complex subunit 7A [IPR037757]", "COP9 signalosome complex subunit 1 [IPR033008]", "COP9 signalosome complex subunit 2 [IPR037750]", "COP9 signalosome complex subunit 3 [IPR037753]", "COP9 signalosome complex subunit 4 [IPR037754]", "COP9 signalosome complex subunit 5 [IPR037740]", "COP9 signalosome subunit 6 [IPR033859]", "COP9 signalosome, subunit CSN8 [IPR033205]", "COPII coat assembly protein, Sec16 [IPR024880]", "COX15/CtaA family [IPR003780]", "CPI-17 [IPR008025]", "CPSF6/7 family [IPR034772]", "CTP synthase [IPR004468]", "CWF11 family [IPR026300]", "CXXC motif containing zinc binding protein, eukaryotic [IPR008584]", "CYFIP-related Rac1 interactor [IPR039789]", "Cadherin [IPR039808]", "Calcium homeostasis endoplasmic reticulum protein [IPR039037]", "Calcium load-activated calcium channel [IPR008559]", "Calcium uptake protein 1/2/3 [IPR039800]", "Calcium-binding mitochondrial carrier protein Aralar2 [IPR029658]", "Calcium-binding protein CAB45 [IPR027240]", "Calcium-transporting ATPase type 2C member 1 [IPR030336]", "Caldesmon [IPR006017]", "Caldesmon/lymphocyte specific protein [IPR006018]", "Calmodulin-regulated spectrin-associated protein [IPR032940]", "Calpain-1 [IPR029643]", "Calpain-2 [IPR029539]", "Calpastatin [IPR026998]", "Calponin-2 [IPR029974]", "Calponin/LIMCH1 [IPR001997]", "Calreticulin [IPR009169]", "Calreticulin/calnexin [IPR001580]", "Calumenin [IPR027239]", "Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 1 [IPR030376]", "Caprin [IPR028816]", "Carbamoyl-phosphate synthase, large subunit [IPR006275]", "Carbamoyl-phosphate synthase, small subunit [IPR006274]", "Carbohydrate sulfotransferase 8-10 [IPR018011]", "Cartilage-associated protein [IPR033212]", "Casein Kinase 2, subunit alpha [IPR045216]", "Casein kinase II, regulatory subunit [IPR000704]", "Cat eye syndrome critical region protein 5 [IPR029621]", "Catechol O-methyltransferase, eukaryotic [IPR017128]", "Catenin delta-1 [IPR028439]", "Cation efflux protein [IPR002524]", "Cation-dependent mannose-6-phosphate receptor [IPR000296]", "Cationic amino acid transport permease [IPR004755]", "Cdc37 [IPR004918]", "Cdc42 [IPR037874]", "Cdc42-interacting protein 4 [IPR028498]", "Cdc73/Parafibromin [IPR007852]", "Cell cycle and apoptosis regulator protein 2 [IPR028811]", "Cell cycle and apoptosis regulator protein [IPR025224]", "Cell cycle checkpoint, Hus1 [IPR016580]", "Cell division cycle protein 123 [IPR009772]", "Cell division protein borealin [IPR018867]", "Cell growth-regulating nucleolar protein [IPR039999]", "Cell-cycle alteration and expression-elevated protein in tumour [IPR032337]", "Centrin 2 [IPR037629]", "Centrosomal protein of 170kDa [IPR026644]", "Centrosomal protein of 290kDa [IPR026201]", "Centrosomal protein of 44kDa [IPR033603]", "Cerebellar degeneration-related protein 2 [IPR026079]", "Ceroid-lipofuscinosis neuronal protein 5 [IPR026138]", "Cgr1-like [IPR005579]", "Chaperone DnaJ [IPR012724]", "Chaperone DnaK [IPR012725]", "Chaperone tailless complex polypeptide 1 (TCP-1) [IPR017998]", "Chaperonin Cpn60/GroEL [IPR001844]", "Chaperonin Cpn60/GroEL/TCP-1 family [IPR002423]", "Charged multivesicular body protein 1a [IPR029888]", "Checkpoint protein Hus1/Mec3 [IPR007150]", "Chitobiosyldiphosphodolichol beta-mannosyltransferase ALG1-like [IPR026051]", "Chloride channel ClC-3 [IPR002245]", "Chloride channel, voltage gated [IPR001807]", "Chloride intracellular channel protein 1 [IPR030259]", "Chloride intracellular channel protein 4/6 [IPR030257]", "Choline transporter-like [IPR007603]", "Chromatin assembly factor 1 subunit A [IPR022043]", "Chromatin assembly factor 1 subunit Cac2/CHAF1B/FAS2 [IPR045145]", "Chromatin-remodeling complex component Sfh1/SNF5 [IPR017393]", "Chromobox protein homologue 3 [IPR038033]", "Chromodomain-helicase-DNA-binding protein 1-like [IPR031053]", "Chromodomain-helicase-DNA-binding protein 8 [IPR034724]", "Chromosome alignment-maintaining phosphoprotein 1 [IPR039330]", "Cilia- and flagella-associated protein 20/CFAP20DC [IPR040441]", "Cip1-interacting zinc finger protein [IPR026811]", "Citrate synthase [IPR002020]", "Citrate synthase, eukaryotic-type [IPR010109]", "Class I-like SAM-dependent O-methyltransferase [IPR002935]", "Clathrin adaptor, mu subunit [IPR001392]", "Clathrin coat assembly protein AP180-like [IPR045192]", "Clathrin interactor 1 [IPR030544]", "Clathrin light chain [IPR000996]", "Clathrin, heavy chain [IPR016341]", "Cleavage and polyadenylation specificity factor subunit 2 [IPR027075]", "Cleavage and polyadenylation specificity factor subunit 6 [IPR034769]", "Cleavage and polyadenylation specificity factor subunit 7 [IPR034770]", "Cleavage stimulation factor subunit 1-like [IPR044633]", "Cleavage stimulation factor subunit 2 [IPR033105]", "Cleavage/polyadenylation specificity factor subunit 5 [IPR016706]", "Cleft lip and palate transmembrane 1 [IPR008429]", "Cleft lip and palate transmembrane protein 1-like protein [IPR030434]", "Clp protease proteolytic subunit /Translocation-enhancing protein TepA [IPR023562]", "Clp protease, ATP-binding subunit ClpX [IPR004487]", "ClpA/B family [IPR001270]", "Cmr1/WDR76 [IPR033052]", "Co-chaperone protein p23-like [IPR045250]", "Coactosin-like protein [IPR030502]", "Coatomer alpha subunit [IPR016391]", "Coatomer beta subunit (COPB1) [IPR016460]", "Coatomer beta' subunit (COPB2) [IPR016453]", "Coatomer delta subunit [IPR027059]", "Coatomer gamma subunit [IPR017106]", "Coatomer subunit zeta [IPR039652]", "Coatomer, epsilon subunit [IPR006822]", "Cobalamin-dependent methionine synthase [IPR011822]", "Coenzyme A transferase family I [IPR004165]", "Cofactor of BRCA1 [IPR010405]", "Cofilin 1 [IPR027234]", "Cohesin subunit Scc3/SA [IPR039662]", "Coiled-coil and C2 domain-containing protein 1 [IPR039725]", "Coiled-coil domain-containing protein 124/Oxs1 [IPR010422]", "Coiled-coil domain-containing protein 127 [IPR034607]", "Coiled-coil domain-containing protein 138 [IPR038798]", "Coiled-coil domain-containing protein 22 [IPR008530]", "Coiled-coil domain-containing protein 86 [IPR026570]", "Coiled-coil domain-containing protein 90-like [IPR024461]", "Coiled-coil domain-containing protein 93 [IPR039116]", "Coilin [IPR024822]", "Condensin complex subunit 2/barren [IPR022816]", "Condensin complex subunit 3 [IPR027165]", "Condensin subunit 1 [IPR007673]", "Condensin subunit 1/Condensin-2 complex subunit D3 [IPR026971]", "Condensin-2 complex subunit G2 [IPR024741]", "Conserved oligomeric Golgi complex subunit 7 [IPR019335]", "Conserved oligomeric Golgi complex subunit 8 [IPR007255]", "Conserved oligomeric Golgi complex subunit 8, Metazoal and Viridiplantae [IPR016632]", "Conserved oligomeric Golgi complex, subunit 3 [IPR007265]", "Constitutive coactivator of PPAR-gamma [IPR026784]", "Copine [IPR045052]", "Copper chaperone SCO1/SenC [IPR003782]", "Coproporphyrinogen III oxidase, aerobic [IPR001260]", "Core histone macro-H2A [IPR021171]", "Core-binding factor, beta subunit [IPR003417]", "Coronin 1C [IPR027333]", "Coronin [IPR015505]", "Cortactin [IPR015503]", "Csn12 family [IPR045114]", "Cullin [IPR045093]", "Cullin-4B [IPR033044]", "Cullin-7 [IPR031223]", "Cullin-associated NEDD8-dissociated protein 1/2 [IPR039852]", "Cwf19-like protein [IPR040194]", "Cyclic nucleotide phosphodiesterase [IPR008431]", "Cyclin [IPR039361]", "Cyclin-dependent kinase 7 [IPR037770]", "Cyclin/Cyclin-like subunit Ssn8 [IPR043198]", "Cyclophilin-RNA interacting protein [IPR035542]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase [IPR024936]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like [IPR044666]", "Cysteine desulfurase IscS [IPR010240]", "Cysteine desulfurase [IPR016454]", "Cysteine protease ATG4B, metazoa [IPR032916]", "Cysteine-tRNA ligase [IPR015803]", "Cysteinyl-tRNA synthetase/mycothiol ligase [IPR024909]", "Cystinyl aminopeptidase [IPR034017]", "Cytochrome B561-related [IPR019176]", "Cytochrome P450 [IPR001128]", "Cytochrome P450, E-class, group I [IPR002401]", "Cytochrome P450, E-class, group IV [IPR002403]", "Cytochrome b-c1 complex subunit 7 [IPR003197]", "Cytochrome b-c1 complex subunit 8 [IPR004205]", "Cytochrome b-c1 complex subunit 9 [IPR008027]", "Cytochrome c oxidase assembly factor 3, mitochondrial [IPR041752]", "Cytochrome c oxidase assembly protein COX14 [IPR029208]", "Cytochrome c oxidase assembly protein CtaG/Cox11 [IPR007533]", "Cytochrome c oxidase subunit 6C [IPR004204]", "Cytochrome c oxidase subunit IV [IPR013288]", "Cytochrome c oxidase subunit IV family [IPR004203]", "Cytochrome c oxidase subunit VII [IPR039297]", "Cytochrome c oxidase subunit VIIa, metazoa [IPR003177]", "Cytochrome c oxidase subunit VIIa-related, mitochondrial [IPR017267]", "Cytochrome c oxidase subunit VIIc [IPR004202]", "Cytochrome c oxidase, subunit Va/VI [IPR003204]", "Cytochrome c oxidase, subunit Vb [IPR002124]", "Cytochrome c/quinol oxidase subunit II [IPR045187]", "Cytochrome c1 [IPR002326]", "Cytoplasmic FMR1-interacting [IPR008081]", "Cytoplasmic dynein 2 heavy chain 1 [IPR026815]", "Cytoskeleton-associated protein 2 family [IPR026165]", "Cytoskeleton-associated protein 4 [IPR028428]", "Cytosolic Fe-S cluster assembly factor NUBP2/Cfd1, eukaryotes [IPR028600]", "Cytosolic acyl coenzyme A thioester hydrolase [IPR040170]", "Cytosolic nonspecific dipeptidase/DUG1 [IPR017153]", "Cytospin-A [IPR040166]", "D-3-phosphoglycerate dehydrogenase [IPR006236]", "DAD/Ost2 [IPR003038]", "DDRGK domain containing protein [IPR019153]", "DDX54/DBP10 family [IPR033517]", "DENR family, eukaryotes [IPR005873]", "DNA (cytosine-5)-methyltransferase 1-like [IPR017198]", "DNA damage-binding protein 1 [IPR031297]", "DNA double-strand break repair protein Mre11 [IPR003701]", "DNA fragmentation factor 45 [IPR017299]", "DNA helicase, ATP-dependent, RecQ type [IPR004589]", "DNA ligase, ATP-dependent [IPR000977]", "DNA mismatch repair Msh2-type [IPR011184]", "DNA mismatch repair MutS family [IPR045076]", "DNA mismatch repair protein Msh2 [IPR032642]", "DNA mismatch repair protein MutS/MSH [IPR017261]", "DNA polymerase V/Myb-binding protein 1A [IPR007015]", "DNA polymerase delta/II small subunit family [IPR024826]", "DNA polymerase epsilon catalytic subunit [IPR029703]", "DNA polymerase epsilon, subunit B [IPR016266]", "DNA primase large subunit, eukaryotic/archaeal [IPR007238]", "DNA primase, large subunit, eukaryotic [IPR016558]", "DNA primase, small subunit [IPR002755]", "DNA primase, small subunit, eukaryotic/archaeal [IPR014052]", "DNA repair protein Rad50, eukaryotes [IPR004584]", "DNA repair/transcription protein MET18/MMS19 [IPR039920]", "DNA replication ATP-dependent helicase/nuclease Dna2 [IPR026851]", "DNA replication complex GINS protein Psf2 [IPR007257]", "DNA replication licensing factor Mcm2 [IPR008045]", "DNA replication licensing factor Mcm3 [IPR008046]", "DNA replication licensing factor Mcm5 [IPR008048]", "DNA replication licensing factor Mcm6 [IPR008049]", "DNA replication licensing factor Mcm7 [IPR008050]", "DNA topoisomerase I [IPR001631]", "DNA topoisomerase II, eukaryotic-type [IPR001154]", "DNA topoisomerase II-beta [IPR028467]", "DNA topoisomerase, type IIA [IPR001241]", "DNA-directed DNA polymerase, family B [IPR006172]", "DNA-directed DNA-polymerase, family A, mitochondria [IPR002297]", "DNA-directed RNA pol I, largest subunit [IPR015699]", "DNA-directed RNA polymerase I, subunit RPA34.5 [IPR013240]", "DNA-directed RNA polymerase II subunit Rpb4-like [IPR045222]", "DNA-directed RNA polymerase III subunit RPC3 [IPR039748]", "DNA-directed RNA polymerase III subunit Rpc5 [IPR006886]", "DNA-directed RNA polymerase subunit RPABC5/Rpb10 [IPR000268]", "DNA-directed RNA polymerase subunit Rpo5/Rpb5 [IPR014381]", "DNA-directed RNA polymerase, phage-type [IPR002092]", "DNA-directed RNA polymerase, subunit 2 [IPR015712]", "DNA-directed RNA polymerase, subunit beta-prime [IPR045867]", "DNA-directed RNA polymerases I and III subunit AC40 [IPR033901]", "DNA2/NAM7-like helicase [IPR045055]", "DPM1-like [IPR039528]", "Death-inducer obliterator 1 [IPR033082]", "Dedicator of cytokinesis [IPR026791]", "Defective-in-cullin neddylation protein [IPR014764]", "Delta l-pyrroline-5-carboxylate synthetase [IPR005766]", "Delta(24)-sterol reductase [IPR040165]", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase Ech1-like [IPR045002]", "Delta-1-pyrroline-5-carboxylate dehydrogenase [IPR005931]", "Deoxyhypusine hydroxylase [IPR027517]", "Deoxyuridine triphosphate nucleotidohydrolase [IPR008181]", "Dephospho-CoA kinase [IPR001977]", "Derlin [IPR007599]", "Dermcidin [IPR028130]", "Dermcidin/Lacritin [IPR043557]", "Desmoglein [IPR009123]", "Desmoplakin [IPR028462]", "Desmosomal cadherin [IPR009122]", "Destrin [IPR029924]", "Deubiquitinating enzyme MINDY-3/4 [IPR039785]", "Developmentally regulated GTP-binding protein [IPR045001]", "Dihydrofolate reductase [IPR012259]", "Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component [IPR045257]", "Dihydrolipoamide dehydrogenase [IPR006258]", "Dihydrolipoamide succinyltransferase [IPR006255]", "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex [IPR006257]", "Dihydroorotate dehydrogenase, class 2 [IPR005719]", "Dihydropyrimidinase-related protein 2 [IPR030615]", "Dihydroxyacetone kinase [IPR012734]", "Dihydroxyacetone phosphate acyltransferase [IPR028353]", "Dim1 family [IPR004123]", "Dimethylarginine dimethylaminohydrolase [IPR033199]", "Dipeptidyl-peptidase 3 [IPR005317]", "Diphosphomevalonate decarboxylase [IPR029765]", "Diphosphomevalonate/phosphomevalonate decarboxylase [IPR005935]", "Diphthamide synthesis DHP2 [IPR010014]", "Diphthamide synthesis DPH1/DPH2 [IPR016435]", "Disks large 1-like [IPR016313]", "Divalent ion tolerance protein, CutA [IPR004323]", "DnaJ homolog subfamily A member 1/2-like [IPR044713]", "DnaJ homolog subfamily C member 8 [IPR042858]", "DnaJ homologue subfamily C member 10 [IPR021170]", "DnaJ homologue subfamily C, GRV2/DNAJC13 [IPR044978]", "Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase [IPR039485]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48kDa subunit [IPR005013]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1 [IPR008814]", "Dolichyldiphosphatase 1 [IPR039666]", "Drebrin [IPR028438]", "Drebrin-like protein [IPR029923]", "Dual specificity protein phosphatase 12 [IPR016278]", "Dymeclin [IPR019142]", "Dynactin subunit 3 [IPR009991]", "Dynactin subunit 4 [IPR008603]", "Dynamin [IPR022812]", "Dynamin-1-like protein [IPR030556]", "Dynamin-2 [IPR027188]", "Dynamin-like 120kDa protein, mitochondrial [IPR033047]", "Dynamitin [IPR028133]", "Dynein 1 light intermediate chain [IPR008467]", "Dynein family light intermediate chain [IPR022780]", "Dynein heavy chain [IPR026983]", "Dynein light chain, type 1/2 [IPR001372]", "Dynein regulator LIS1 [IPR017252]", "Dyslexia-associated protein KIAA0319-like [IPR029865]", "Dystrophin/utrophin [IPR035436]", "E3 SUMO-protein ligase Nse2 (Mms21) [IPR026846]", "E3 UFM1-protein ligase 1 [IPR018611]", "E3 ubiquitin ligase Bre1 [IPR013956]", "E3 ubiquitin ligase RBR family [IPR031127]", "E3 ubiquitin ligase UBR4-like [IPR045189]", "E3 ubiquitin-protein ligase ARIH2 [IPR031126]", "E3 ubiquitin-protein ligase CHIP/LubX [IPR045200]", "E3 ubiquitin-protein ligase HECTD1/TRIP12-like [IPR045322]", "E3 ubiquitin-protein ligase RBBP6 family [IPR033489]", "E3 ubiquitin-protein ligase RING1/RING2 [IPR043540]", "E3 ubiquitin-protein ligase RING2 [IPR037937]", "E3 ubiquitin-protein ligase UBR7 [IPR040204]", "E3 ubiquitin-protein ligase ZNF598/Hel2 [IPR044288]", "E3 ubiquitin-protein ligase, SMURF1 type [IPR024928]", "EB1, Metazoa [IPR027739]", "EB2, vertebrate [IPR027735]", "ECSIT [IPR010418]", "EF-hand domain-containing protein D1/2 [IPR040365]", "EH domain-containing protein 1/3 [IPR029951]", "EH domain-containing protein 4 [IPR029952]", "ELL/occludin family [IPR031176]", "ELMO domain-containing protein 2 [IPR030724]", "ELP3/YhcC [IPR039661]", "ER lumen protein retaining receptor [IPR000133]", "ER membrane protein complex subunit 1 [IPR026895]", "ER membrane protein complex subunit 2-like [IPR039856]", "ER membrane protein complex subunit 3 [IPR008568]", "ER membrane protein complex subunit 7 [IPR039163]", "ER membrane protein complex subunit 8/9 [IPR005366]", "ERG2/sigma1 receptor-like [IPR006716]", "ERp19 [IPR037462]", "ESCRT-II complex, Vps25 subunit [IPR008570]", "Ecd family [IPR010770]", "Electron transfer flavoprotein alpha subunit/FixB [IPR001308]", "Electron transfer flavoprotein, beta subunit [IPR012255]", "Electron transfer flavoprotein-ubiquinone oxidoreductase [IPR040156]", "Elongation factor 4 [IPR006297]", "Elongation factor G1-like [IPR045044]", "Elongator complex protein 1 [IPR006849]", "Elongator complex protein 2 [IPR037289]", "Elongator complex protein 3-like [IPR034687]", "Elongin B [IPR039049]", "Elongin-C [IPR039948]", "Emerin [IPR035004]", "Endonuclease domain-containing 1 protein [IPR039015]", "Endophilin-A [IPR028501]", "Endophilin-B1 [IPR028503]", "Endoplasmic reticulum aninopeptidase 1 [IPR033520]", "Endoplasmic reticulum oxidoreductin 1 [IPR007266]", "Endoplasmic reticulum protein SC65 [IPR033213]", "Endoplasmic reticulum resident protein 29 [IPR016855]", "Endoplasmic reticulum vesicle transporter [IPR045888]", "Endothelin-converting enzyme 1 [IPR029734]", "Engulfment and cell motility protein 2 [IPR030713]", "Enhancer of mRNA-decapping protein 4-like [IPR045152]", "Enhancer of rudimentary [IPR000781]", "Enolase [IPR000941]", "Enoyl-CoA hydratase/isomerase [IPR001753]", "Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type [IPR032259]", "Ependymin [IPR001299]", "Ephrin receptor type-A /type-B [IPR016257]", "Epimerase family protein SDR39U1 [IPR010099]", "Epoxide hydrolase [IPR016292]", "Epoxide hydrolase-like [IPR000639]", "Equilibrative nucleoside transporter 1 [IPR030195]", "Equilibrative nucleoside transporter [IPR002259]", "Ergosterol biosynthesis ERG4/ERG24 [IPR001171]", "Erlin1/2 [IPR033294]", "Est1/Ebs1-like [IPR045153]", "Esterase-like [IPR000801]", "Eukaryotic porin/Tom40 [IPR027246]", "Eukaryotic rRNA processing [IPR008610]", "Eukaryotic translation elongation factor 1 epsilon-1 [IPR042450]", "Eukaryotic translation initiation factor 2D [IPR039757]", "Eukaryotic translation initiation factor 3 subunit A [IPR027512]", "Eukaryotic translation initiation factor 3 subunit B [IPR011400]", "Eukaryotic translation initiation factor 3 subunit D [IPR007783]", "Eukaryotic translation initiation factor 3 subunit E [IPR016650]", "Eukaryotic translation initiation factor 3 subunit F [IPR027531]", "Eukaryotic translation initiation factor 3 subunit G [IPR017334]", "Eukaryotic translation initiation factor 3 subunit H [IPR027524]", "Eukaryotic translation initiation factor 3 subunit I [IPR027525]", "Eukaryotic translation initiation factor 3 subunit J [IPR013906]", "Eukaryotic translation initiation factor 3 subunit K [IPR009374]", "Eukaryotic translation initiation factor 3 subunit M [IPR027528]", "Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7 [IPR045237]", "Eukaryotic translation initiation factor 4 gamma 1 [IPR037584]", "Eukaryotic translation initiation factor 4 gamma 3 [IPR037585]", "Eukaryotic translation initiation factor 4B [IPR033107]", "Exocyst complex component EXOC2/Sec5 [IPR029175]", "Exocyst complex component EXOC5/Sec10 [IPR033960]", "Exocyst complex component EXOC6/Sec15 [IPR007225]", "Exocyst complex component Exo70 [IPR004140]", "Exocyst complex component Sec10-like [IPR009976]", "Exocyst complex component Sec8/EXOC4 [IPR039682]", "Exonuclease 1 [IPR032641]", "Exosome complex RNA-binding protein 1/RRP40/RRP4 [IPR026699]", "Exosome complex component Csl4 [IPR039771]", "Exosome complex component RRP45 [IPR033100]", "Exosome complex component Rrp43 [IPR033196]", "Exosome complex exonuclease Rrp6-like [IPR045092]", "Exportin 4/7-like [IPR044189]", "Exportin-1/5 [IPR045065]", "Exportin-5 [IPR040018]", "Exportin-7 [IPR040021]", "Exportin-T [IPR040017]", "Ezrin/radixin/moesin [IPR011174]", "Ezrin/radixin/moesin-like [IPR000798]", "F-actin-capping protein subunit alpha [IPR002189]", "F-actin-capping protein subunit beta [IPR001698]", "FACT complex subunit Spt16 [IPR040258]", "FAD synthetase with the MoaB/Mog domain [IPR012183]", "FAD-dependent glycerol-3-phosphate dehydrogenase [IPR000447]", "FAD-dependent oxidoreductase SdhA/FrdA/AprA [IPR030664]", "FAM105 [IPR023235]", "FAM177 family [IPR028260]", "FAM3 family [IPR039220]", "FAM98 [IPR018797]", "FH1/FH2 domain-containing protein 1 [IPR027647]", "FUN14 [IPR007014]", "Fanconi anaemia protein FANCD2 [IPR029448]", "Fanconi anemia group I protein [IPR026171]", "Far11/STRP [IPR040185]", "Fascin [IPR010431]", "Fascin, metazoans [IPR024703]", "Fascin-1 [IPR030146]", "Fatty acid desaturase [IPR012171]", "Fatty acid oxidation complex, alpha subunit, mitochondrial [IPR012803]", "Fatty acid transport protein 4 [IPR030304]", "Fatty acyl-CoA reductase [IPR026055]", "Fcf2/DNTTIP2 [IPR039883]", "Ferredoxin-NADP+ reductase, adrenodoxin-type [IPR021163]", "Ferritin [IPR001519]", "Ferrochelatase [IPR001015]", "Fibrillarin [IPR000692]", "Filamin family [IPR044801]", "Filamin-B [IPR029874]", "Fimbrin/Plastin [IPR039959]", "Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 [IPR033756]", "Flap endonuclease 1 [IPR023426]", "Flotillin family [IPR027705]", "Formate-tetrahydrofolate ligase, FTHFS [IPR000559]", "Formin, protein diaphanous homologue 1 [IPR027653]", "Formin, protein diaphanous homologue 3 [IPR027654]", "Formin-binding protein 1 [IPR028532]", "Four and a half LIM domains protein 1 [IPR042997]", "Fragile X mental retardation syndrome-related protein [IPR040148]", "Fructose-bisphosphate aldolase, class-I [IPR000741]", "Fumarate hydratase, class II [IPR005677]", "Fumarate lyase family [IPR000362]", "Fumarylacetoacetase [IPR005959]", "G-protein alpha subunit, group 12/13 [IPR000469]", "G-protein alpha subunit, group I [IPR001408]", "G-rich sequence factor 1 [IPR033106]", "G10 protein [IPR001748]", "GDP dissociation inhibitor [IPR018203]", "GDP-fucose protein O-fucosyltransferase 1 [IPR039922]", "GDP-fucose protein O-fucosyltransferase [IPR019378]", "GH3 family [IPR004993]", "GINS complex subunit Sld5 [IPR008591]", "GINS complex, subunit Psf1 [IPR005339]", "GINS complex, subunit Psf3 [IPR010492]", "GOSR2/Membrin/Bos1 [IPR027027]", "GPCR-associated sorting protein [IPR043374]", "GPI ethanolamine phosphate transferase 2 [IPR039527]", "GPI mannosyltransferase [IPR005599]", "GPI transamidase component PIG-T [IPR007245]", "GPI-anchor transamidase [IPR028361]", "GRASP55/65 [IPR007583]", "GRIM-19 [IPR009346]", "GTP-binding protein 1 [IPR039263]", "GTP-binding protein Era [IPR005662]", "Galactokinase [IPR000705]", "Galectin-3 [IPR015534]", "Galectin-like [IPR044156]", "Gamma tubulin [IPR002454]", "Gamma-adducin [IPR027772]", "Gamma-glutamylcyclotransferase [IPR017939]", "Gamma-tubulin complex component protein [IPR007259]", "Ganglioside GM2 activator [IPR028996]", "Ganglioside-induced differentiation-associated protein 1 [IPR034336]", "Gem-associated protein 4 [IPR033265]", "General transcription factor 3C polypeptide 4 [IPR044230]", "Geranylgeranyl transferase type-2 subunit alpha [IPR032955]", "Glia maturation factor [IPR011171]", "Glomulin/ALF4 [IPR019516]", "Glu-tRNAGln amidotransferase C subunit [IPR003837]", "Glucosamine 6-phosphate N-acetyltransferase [IPR039143]", "Glucosamine-6-phosphate isomerase [IPR004547]", "Glucosamine-fructose-6-phosphate aminotransferase, isomerising [IPR005855]", "Glucose transporter GLUT [IPR045263]", "Glucose transporter, type 1 (GLUT1) [IPR002439]", "Glucose-6-phosphate dehydrogenase [IPR001282]", "Glucosidase II beta subunit-like [IPR039794]", "Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase [IPR005715]", "Glutamate carboxypeptidase 2-like [IPR039373]", "Glutamate-cysteine ligase catalytic subunit [IPR004308]", "Glutamate-tRNA ligase, bacterial/mitochondrial [IPR004527]", "Glutamate/acetylglutamate kinase [IPR001057]", "Glutamate/phenylalanine/leucine/valine dehydrogenase [IPR006095]", "Glutaminase [IPR015868]", "Glutamine-tRNA synthetase [IPR004514]", "Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic [IPR004526]", "Glutamyl-tRNA(Gln) amidotransferase A subunit [IPR004412]", "Glutamyl/glutaminyl-tRNA synthetase [IPR000924]", "Glutathione S-transferase Omega/Tau-like [IPR045073]", "Glutathione S-transferase kappa [IPR044088]", "Glutathione S-transferase, Mu class [IPR003081]", "Glutathione S-transferase, omega-class [IPR005442]", "Glutathione S-transferases, class Zeta [IPR005955]", "Glutathione Transferase family [IPR040079]", "Glutathione peroxidase Gpx7, putative [IPR013376]", "Glutathione peroxidase [IPR000889]", "Glutathione reductase, eukaryote/bacterial [IPR006322]", "Glutathione synthase [IPR005615]", "Glutathione-specific gamma-glutamylcyclotransferase [IPR006840]", "Glyceraldehyde-3-phosphate dehydrogenase, type I [IPR006424]", "Glyceraldehyde/Erythrose phosphate dehydrogenase family [IPR020831]", "Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase [IPR022284]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent [IPR006168]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic [IPR017751]", "Glycine cleavage system P protein [IPR020581]", "Glycine dehydrogenase (decarboxylating) [IPR003437]", "Glycogen debranching enzyme [IPR010401]", "Glycogen debranching enzyme, metazoa [IPR006421]", "Glycogen synthase [IPR008631]", "Glycogen synthase kinase-3 beta [IPR033573]", "Glycogen/starch/alpha-glucan phosphorylase [IPR011833]", "Glycoside hydrolase family 30 [IPR001139]", "Glycoside hydrolase family 31 [IPR000322]", "Glycoside hydrolase family 47 [IPR001382]", "Glycoside hydrolase family 63 [IPR004888]", "Glycoside hydrolase, family 2 [IPR006101]", "Glycoside hydrolase, family 27 [IPR002241]", "Glycoside hydrolase, family 29 [IPR000933]", "Glycoside hydrolase, family 35 [IPR001944]", "Glycosyl transferase family 29 [IPR001675]", "Glycosyl transferase, family 25 [IPR002654]", "Glycosyl transferase, family 31 [IPR002659]", "Glycosyl transferase, family 35 [IPR000811]", "Glycosyl transferase, family 8 [IPR002495]", "Glycyl-tRNA synthetase [IPR002315]", "Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2 [IPR027031]", "Glyoxalase I [IPR004361]", "Glyoxalase domain-containing protein 4 [IPR043193]", "Golgi SNAP receptor complex, subunit 1 [IPR023601]", "Golgi apparatus protein 1 [IPR039728]", "Golgi phosphoprotein 3-like [IPR008628]", "Golgi to ER traffic protein 4 [IPR007317]", "Golgin subfamily A [IPR024858]", "Golgin subfamily A member 3 [IPR033288]", "Golgin subfamily A member 5 [IPR019177]", "Golgin subfamily B member 1 [IPR026202]", "Graves disease carrier protein [IPR002167]", "GroES chaperonin family [IPR020818]", "Growth arrest/ DNA-damage-inducible protein-interacting protein 1 [IPR018472]", "GrpE nucleotide exchange factor [IPR000740]", "Guanine nucleotide binding protein (G-protein), alpha subunit [IPR001019]", "Guanine nucleotide-exchange factor Sec12-like [IPR045260]", "H/ACA ribonucleoprotein complex non-core subunit Naf1 [IPR040309]", "H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 [IPR007504]", "H/ACA ribonucleoprotein complex, subunit Nhp2, eukaryote [IPR002415]", "H/ACA ribonucleoprotein complex, subunit Nop10 [IPR007264]", "HAD hydrolase, LHPP/HDHD2 [IPR006355]", "HAD hydrolase, subfamily IA [IPR006439]", "HAD-superfamily hydrolase, subfamily IA, REG-2-like [IPR011949]", "HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase [IPR008380]", "HAD-superfamily hydrolase, subfamily IIA [IPR006357]", "HAD-superfamily hydrolase, subfamily IIA, CECR5 [IPR006353]", "HAUS augmin-like complex subunit 1 [IPR026243]", "HAUS augmin-like complex subunit 2 [IPR028346]", "HAUS augmin-like complex subunit 2, metazoa [IPR026242]", "HAUS augmin-like complex subunit 4 [IPR029327]", "HAUS augmin-like complex subunit 4, metazoa [IPR026214]", "HAUS augmin-like complex subunit 5 [IPR029131]", "HAUS complex subunit 5, metazoa [IPR026215]", "HCCA isomerase/glutathione S-transferase kappa [IPR014440]", "HMG domain-containing protein 4 [IPR042477]", "HMG-CoA lyase [IPR043594]", "HS1-associating protein X-1 [IPR017248]", "Haem oxygenase [IPR002051]", "Haem oxygenase-like [IPR016053]", "Haloacid dehalogenase-like hydrolase [IPR041492]", "Ham1-like protein [IPR002637]", "Heat shock 70kDa protein 13 [IPR042048]", "Heat shock protein 70 family [IPR013126]", "Heat shock protein Hsp90 family [IPR001404]", "Heat shock protein Sti1-like [IPR045248]", "Helicase MOV-10 [IPR026122]", "Helicase XPB/Ssl2 [IPR001161]", "Heme A synthase, type 2 [IPR023754]", "Heparan sulphate 2-O-sulfotransferase [IPR007734]", "Heterochromatin protein 1-binding protein 3 [IPR033061]", "Heterogeneous nuclear ribonucleoprotein C [IPR017347]", "Heterogeneous nuclear ribonucleoprotein K [IPR033090]", "Heterogeneous nuclear ribonucleoprotein M [IPR024667]", "Heterogeneous nuclear ribonucleoprotein U [IPR026745]", "Heterogeneous nuclear ribonucleoprotein U-like protein 1 [IPR027025]", "Hexokinase [IPR001312]", "High mobility group protein HMG-I/HMG-Y, chordates [IPR031079]", "High mobility group protein HMGA [IPR000116]", "High mobility group protein HMGB1 [IPR031076]", "High mobility group protein HMGB3 [IPR031077]", "High mobility group protein HMGN [IPR000079]", "Higher eukaryotic phosphomevalonate kinase [IPR005919]", "Histidine acid phosphatase, eukaryotic [IPR016274]", "Histidine phosphatase superfamily, clade-1 [IPR013078]", "Histidine phosphatase superfamily, clade-2 [IPR000560]", "Histidine triad (HIT) protein [IPR001310]", "Histidine-tRNA ligase [IPR015807]", "Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit [IPR004516]", "Histone H2A [IPR002119]", "Histone H4 [IPR001951]", "Histone acetyltransferase type B, catalytic subunit [IPR017380]", "Histone chaperone ASF1-like [IPR006818]", "Histone deacetylase [IPR003084]", "Histone deacetylase complex, SAP18 subunit [IPR017250]", "Histone deacetylase family [IPR000286]", "Histone demethylase JHDM2-like [IPR045109]", "Histone lysine-specific demethylase [IPR017366]", "Histone methyltransferase complex subunit ASH2 [IPR037353]", "Histone-lysine N-methyltransferase EHMT1 [IPR038035]", "Histone-lysine N-methyltransferase EHMT1/EHMT2 [IPR043550]", "Histone-lysine N-methyltransferase EHMT2 [IPR038034]", "Histone-lysine N-methyltransferase SETDB1 [IPR025796]", "HnRNP R/Q splicing factor [IPR006535]", "HnRNP-L/PTB [IPR006536]", "Holocytochrome c/c1 synthase [IPR000511]", "Host cell factor 1 [IPR037854]", "Host cell factor [IPR043536]", "Huntingtin [IPR000091]", "Huntingtin family [IPR028426]", "Hydantoinase/dihydropyrimidinase [IPR011778]", "Hydroxymethylglutaryl-CoA reductase, class I/II [IPR002202]", "Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type [IPR004554]", "Hydroxymethylglutaryl-CoA reductase, metazoan [IPR004816]", "Hydroxymethylglutaryl-CoA synthase, eukaryotic [IPR010122]", "Hypoxanthine phosphoribosyl transferase [IPR005904]", "I-BAR domain containing protein IRSp53 [IPR030128]", "I-BAR domain containing protein IRSp53/IRTKS/Pinkbar [IPR027681]", "ICln [IPR003521]", "ISC system FeS cluster assembly, IscU scaffold [IPR011339]", "Immunity-related GTPase family Q protein [IPR040070]", "Importin beta family [IPR040122]", "Importin subunit alpha [IPR024931]", "Inhibitor of nuclear factor kappa-B kinase-interacting protein [IPR024152]", "Initiation factor 2B-related [IPR000649]", "Initiation factor 4G [IPR045208]", "Inner centromere protein [IPR039130]", "Inner nuclear membrane protein Man1 [IPR034997]", "Inorganic pyrophosphatase [IPR008162]", "Inosine triphosphate pyrophosphatase [IPR027502]", "Inosine-5'-monophosphate dehydrogenase [IPR005990]", "Inositol 1,4,5-trisphosphate receptor-interacting protein [IPR024797]", "Inositol 1,4,5-trisphosphate receptor-interacting protein family [IPR026250]", "Inositol 3,4-bisphosphate 4-phosphatase [IPR039034]", "Inositol monophosphatase-like [IPR000760]", "Insulin receptor substrate [IPR039011]", "Insulin-like growth factor 2 mRNA-binding protein 2 [IPR028743]", "Integral membrane protein EMC3/TMCO1-like [IPR002809]", "Integrator complex subunit 1 [IPR038902]", "Integrator complex subunit 10 [IPR026164]", "Integrator complex subunit 12 [IPR039053]", "Integrator complex subunit 14 [IPR039841]", "Integrator complex subunit 3 [IPR045334]", "Integrator complex subunit 8 [IPR038751]", "Integrin alpha chain [IPR000413]", "Integrin beta subunit [IPR015812]", "Integrin beta-1 subunit [IPR027071]", "Interferon-inducible double-stranded RNA-dependent protein kinase activator A [IPR033363]", "Interleukin enhancer-binding factor 3 [IPR033099]", "Intracellular chloride channel [IPR002946]", "Intraflagellar transport protein 27 homologue, eukaryotes [IPR034112]", "Intron Large complex component GCFC2-like [IPR012890]", "Inverted formin-2 [IPR027649]", "Iron regulatory protein 1 [IPR029784]", "Isocitrate dehydrogenase NAD-dependent [IPR004434]", "Isocitrate dehydrogenase NADP-dependent [IPR004790]", "Isoleucine-tRNA ligase [IPR002301]", "Isoleucine-tRNA ligase, type 1 [IPR023585]", "Isoleucine-tRNA ligase, type 2 [IPR023586]", "Isopentenyl-diphosphate delta-isomerase, type 1 [IPR011876]", "Isoprenylcysteine carboxyl methyltransferase [IPR007269]", "Isovaleryl-CoA dehydrogenase [IPR034183]", "J-protein Zuotin/DnaJC2 [IPR044634]", "JNK-interacting protein 3/4 [IPR039911]", "Janus [IPR007702]", "Junction plakoglobin [IPR030461]", "Junctional adhesion molecule A [IPR042456]", "KH domain-containing BBP-like [IPR045071]", "KIF-1 binding protein [IPR022083]", "KIN17-like protein [IPR037321]", "KRR1 interacting protein 1 [IPR018034]", "Kae1/TsaD family [IPR017861]", "Keratin, type I [IPR002957]", "Keratinocyte-associated transmembrane protein 2 [IPR037645]", "Kindlin/fermitin [IPR037843]", "Kinectin [IPR024854]", "Kinesin light chain [IPR002151]", "Kinesin-like protein KIF20A [IPR027326]", "Kinesin-like protein KIF22 (Kid) [IPR026986]", "Kinesin-like protein [IPR027640]", "Kinetochore protein Spc25 [IPR045143]", "Kinetochore-Ndc80 subunit Spc24 [IPR013252]", "Ku70 [IPR006165]", "Ku80 [IPR024193]", "Kynurenine--oxoglutarate transaminase 3 [IPR034612]", "L-lactate dehydrogenase [IPR011304]", "L-lactate/malate dehydrogenase [IPR001557]", "LAMTOR1/MEH1 [IPR028209]", "LAR-interacting protein, Liprin [IPR029515]", "LEM domain-containing protein 2 [IPR034994]", "LETM1/MDM38-like [IPR044202]", "LIM domain and actin-binding protein 1 [IPR028740]", "LIM domain and actin-binding protein LIMA-like [IPR045268]", "LIM domain-binding protein 1 [IPR030167]", "LIM-domain binding protein/SEUSS [IPR029005]", "LRP chaperone MESD [IPR019330]", "La domain containing protein [IPR045180]", "Las1 [IPR007174]", "Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase [IPR003386]", "Lethal(2) giant larvae protein [IPR000664]", "Leucine zipper transcription factor-like protein 1 [IPR026157]", "Leucine-rich PPR motif-containing protein [IPR033490]", "Leucine-rich repeat protein SHOC2 [IPR027036]", "Leucine-tRNA ligase [IPR002302]", "Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic [IPR004493]", "Leukocyte elastase inhibitor (serpin B1) [IPR015557]", "Leukocyte surface antigen CD47 [IPR006704]", "Leukotriene A4 hydrolase/leucine aminopeptidase [IPR012777]", "Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase [IPR014190]", "LicD family [IPR007074]", "Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3 [IPR027141]", "Linker histone H1/H5 [IPR005819]", "Lipase maturation factor [IPR009613]", "Lipase, eukaryotic [IPR025483]", "Lipid droplet-associated hydrolase [IPR019363]", "Liprin-alpha-1 [IPR030438]", "Lon protease [IPR027065]", "Lon protease homologue, chloroplastic/mitochondrial [IPR027503]", "Lon protease, bacterial/eukaryotic-type [IPR004815]", "Long-chain fatty acid CoA synthetase, eukaryotic [IPR045311]", "Low temperature viability protein Ltv1 [IPR007307]", "Luc7-related [IPR004882]", "Lunapark family [IPR040115]", "Lupus La protein [IPR002344]", "Lysine-tRNA ligase, class II [IPR002313]", "Lysophosphatidylserine lipase ABHD12 [IPR026605]", "Lysosomal thioesterase PPT2 [IPR030295]", "Lysosome membrane protein II [IPR005429]", "Lysosome-associated membrane glycoprotein [IPR002000]", "MCT-1/Tma20 [IPR016437]", "MCU family [IPR039055]", "MDN2-binding protein [IPR039061]", "MICOS complex subunit MIC19/MIC25 [IPR007964]", "MICOS complex subunit MIC26/MIC27 [IPR019166]", "MICOS complex subunit MIC26/MIC27, animal [IPR033182]", "MICOS complex subunit Mic13 [IPR026769]", "MRG [IPR008676]", "MRPS27/PTCD2 [IPR034913]", "MT-A70-like [IPR007757]", "Macrophage migration inhibitory factor [IPR001398]", "Mad2-like [IPR045091]", "Magnesium transporter protein 1 [IPR006844]", "Major facilitator superfamily [IPR011701]", "Major facilitator, sugar transporter-like [IPR005828]", "Mak16 protein [IPR006958]", "Malate dehydrogenase, NAD-dependent, cytosolic [IPR011274]", "Malate dehydrogenase, type 1 [IPR010097]", "Malate dehydrogenase, type 2 [IPR010945]", "Malectin [IPR039155]", "Malic oxidoreductase [IPR001891]", "Manganese/iron superoxide dismutase [IPR001189]", "Mannose-6-phosphate isomerase [IPR016305]", "Mannose-6-phosphate isomerase, type I [IPR001250]", "Mannose-6-phosphate receptor [IPR028927]", "Matrix-remodeling-associated protein 7 [IPR026622]", "Mediator complex, subunit Med14 [IPR013947]", "Mediator complex, subunit Med16 [IPR021665]", "Mediator complex, subunit Med23 [IPR021629]", "Mediator complex, subunit Med24, [IPR021429]", "Mediator complex, subunit Med4 [IPR019258]", "Medium-chain dehydrogenase/reductase [IPR045010]", "Medium-chain specific acyl-CoA dehydrogenase [IPR034180]", "Melanoma-associated antigen D2 [IPR028810]", "Melanoma-associated antigen [IPR037445]", "Membrane insertase YidC/ALB3/OXA1/COX18 [IPR001708]", "Membrane bound O-acyl transferase, MBOAT [IPR004299]", "Membrane magnesium transporter [IPR018937]", "Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein [IPR001129]", "Mesoderm induction early response protein/metastasis-associated protein [IPR040138]", "Metal-dependent protein hydrolase [IPR003226]", "Metastasis-associated protein MTA2 [IPR037964]", "Methionine-tRNA ligase, type 1 [IPR023458]", "Methionyl-tRNA synthetase [IPR014758]", "Methyl-CpG binding protein MeCP2 [IPR017353]", "Methyl-CpG binding protein MeCP2/MBD4 [IPR045138]", "Methyl-CpG-binding domain protein 3 [IPR037965]", "Methylcrotonoyl-CoA carboxylase beta chain MCCB/AccD1-like [IPR045190]", "Methylmalonate-semialdehyde dehydrogenase [IPR010061]", "Methylpurine-DNA glycosylase [IPR003180]", "Methylthioadenosine phosphorylase (MTAP) [IPR010044]", "Methylthiotransferase [IPR005839]", "Methyltransferase Ppm1/Ppm2/Tcmp [IPR007213]", "Mevalonate/galactokinase [IPR006206]", "Mff/Tango-11 [IPR008518]", "MiaB-like tRNA modifying enzyme, archaeal-type [IPR006466]", "Microfibrillar-associated protein 1 [IPR033194]", "Microprocessor complex subunit DGCR8 [IPR040375]", "Microtubule associated protein 1 [IPR026074]", "Microtubule-associated protein 1B [IPR027321]", "Microtubule-associated protein 1S [IPR027322]", "Microtubule-associated protein 4 [IPR027323]", "Microtubule-associated protein 7 family [IPR008604]", "Microtubule-associated protein Jupiter [IPR033335]", "Microtubule-associated protein RP/EB [IPR027328]", "Microtubule-associated protein, MAP65/Ase1/PRC1 [IPR007145]", "Midasin [IPR012099]", "Midline-1 [IPR027727]", "Mini-chromosome maintenance complex protein 4 [IPR008047]", "Mini-chromosome maintenance complex-binding protein [IPR019140]", "Mini-chromosome maintenance protein [IPR031327]", "Minichromosome maintenance protein 10 [IPR040184]", "Mitochondrial 18kDa protein [IPR019560]", "Mitochondrial 28S ribosomal protein S31 [IPR026299]", "Mitochondrial 28S ribosomal protein S34 [IPR032053]", "Mitochondrial ATP synthase subunit g, animal [IPR016702]", "Mitochondrial ATPase inhibitor [IPR007648]", "Mitochondrial F1-F0 ATP synthase subunit F, predicted [IPR019344]", "Mitochondrial Rho GTPase [IPR021181]", "Mitochondrial antiviral-signalling protein, metazoan [IPR026148]", "Mitochondrial calcium uniporter regulator 1 [IPR012439]", "Mitochondrial carrier UCP-like [IPR002030]", "Mitochondrial carrier protein [IPR002067]", "Mitochondrial dynamics protein MID49/MID51 [IPR045909]", "Mitochondrial glycoprotein [IPR003428]", "Mitochondrial import inner membrane translocase subunit Tim44 [IPR017303]", "Mitochondrial import inner membrane translocase subunit Tim50 [IPR027111]", "Mitochondrial import inner membrane translocase subunit Tim8/13 [IPR039238]", "Mitochondrial import receptor subunit TOM5, metazoa [IPR029179]", "Mitochondrial import receptor subunit TOM6 homologue [IPR029182]", "Mitochondrial import receptor subunit Tom22 [IPR005683]", "Mitochondrial inner membrane protein Mitofilin [IPR019133]", "Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678]", "Mitochondrial inner membrane translocase complex, subunit Tim23 [IPR005681]", "Mitochondrial outer membrane translocase complex, subunit Tom5 [IPR019603]", "Mitochondrial phosphate carrier protein Pic2/Mir1-like [IPR044677]", "Mitochondrial processing peptidase subunit beta [IPR037718]", "Mitochondrial pyruvate carrier [IPR005336]", "Mitochondrial ribonuclease P catalytic subunit [IPR033495]", "Mitochondrial ribosomal protein L48 [IPR027487]", "Mitochondrial-processing peptidase subunit alpha [IPR037715]", "Mitofusin family [IPR027094]", "Mitofusin-2 [IPR027089]", "Mitogen-activated protein (MAP) kinase kinase kinase 7 [IPR017421]", "Mitogen-activated protein (MAP) kinase p38-like [IPR008352]", "Mitogen-activated protein (MAP) kinase phosphatase [IPR008343]", "Mitogen-activated protein (MAP) kinase, ERK1/2 [IPR008349]", "Mitogen-activated protein kinase 14 [IPR038784]", "Mitotic spindle checkpoint protein Bub1/Mad3 [IPR015661]", "Mo25-like [IPR013878]", "Molecular chaperone regulator BAG [IPR039773]", "Molybdate-anion transporter [IPR008509]", "Molybdate-anion transporter, animal type [IPR030163]", "Monocarboxylate transporter 1 [IPR030757]", "Monocarboxylate transporter [IPR004743]", "Monothiol glutaredoxin-related [IPR004480]", "Mortality factor 4-like protein 1 [IPR038011]", "Mpv17/PMP22 [IPR007248]", "Mrp/NBP35 ATP-binding protein [IPR019591]", "Multidrug resistance protein 1 [IPR030258]", "Multiple myeloma tumor-associated protein 2-like [IPR039207]", "Myelin expression factor 2 [IPR034632]", "Myeloid-derived growth factor [IPR018887]", "Myo-inositol-1-phosphate synthase [IPR002587]", "Myristoyl-CoA:protein N-myristoyltransferase [IPR000903]", "N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 [IPR033202]", "N-acetylglucosamine-6-sulfatase [IPR012251]", "N-acetylglucosamine-6-sulfatase, metazoan [IPR015981]", "N-acetyltransferase Ard1-like [IPR045047]", "N-acetyltransferase B complex, non-catalytic subunit [IPR019183]", "N-alpha-acetyltransferase 40 [IPR039949]", "N-cadherin [IPR030051]", "N-terminal acetyltransferase A, auxiliary subunit [IPR021183]", "N6-adenosine-methyltransferase MT-A70-like [IPR025848]", "NAD kinase 2, mitochondrial [IPR012355]", "NAD kinase [IPR002504]", "NAD(P) transhydrogenase, alpha subunit [IPR026255]", "NAD(P)H-quinone oxidoreductase subunit D/H [IPR022885]", "NAD/FAD transporter SLC25A32-like [IPR044712]", "NADH dehydrogenase, subunit C [IPR010218]", "NADH ubiquinone oxidoreductase, F subunit [IPR011537]", "NADH-plastoquinone oxidoreductase, chain 5 subgroup [IPR018393]", "NADH-quinone oxidoreductase subunit E-like [IPR002023]", "NADH-quinone oxidoreductase, chain 5-like [IPR003945]", "NADH-quinone oxidoreductase, chain I [IPR010226]", "NADH-ubiquinone oxidoreductase, 20 Kd subunit [IPR006138]", "NADH-ubiquinone oxidoreductase, subunit 10 [IPR019377]", "NADH-ubiquinone reductase complex 1 MLRQ subunit [IPR010530]", "NADH:cytochrome b5 reductase-like [IPR001834]", "NADH:ubiquinone oxidoreductase, ESSS subunit [IPR019329]", "NADH:ubiquinone oxidoreductase, iron-sulphur subunit 5 [IPR019342]", "NADH:ubiquinone oxidoreductase, subunit G [IPR010228]", "NADH:ubiquinone oxidoreductase, subunit NDUFB4 [IPR009866]", "NADPH-cytochrome P450 reductase [IPR023208]", "NDRG [IPR004142]", "NDUFAF3/Mth938 domain-containing protein [IPR007523]", "NEDD8 ultimate buster 1 [IPR039749]", "NEDD8-activating enzyme E1 catalytic subunit [IPR030468]", "NEDD8-activating enzyme E1 regulatory subunit APP-BP1 [IPR030667]", "NOL6/Upt22 [IPR005554]", "NPC1-like [IPR004765]", "NSF attachment protein [IPR000744]", "Na(+)/H(+) exchange regulatory cofactor NHERF-1 [IPR031199]", "Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 [IPR017300]", "Nck-associated protein 1 [IPR019137]", "Negative cofactor 2 complex subunit beta [IPR042225]", "Negative elongation factor E [IPR033102]", "Nesprin-2 [IPR030266]", "Nestin [IPR031211]", "Neurabin-2 [IPR029921]", "Neurabin-like family [IPR043446]", "Neurochondrin [IPR008709]", "Neurofilament light polypeptide [IPR027692]", "Neurofilament medium polypeptide [IPR027697]", "Neuropilin [IPR014648]", "Neuropilin-1 [IPR027146]", "Niban-like [IPR026088]", "Nibrin [IPR016592]", "Nibrin-related [IPR040227]", "Nicalin [IPR016574]", "Nicastrin [IPR008710]", "Nicotinamide phosphoribosyl transferase [IPR016471]", "Nitric oxide synthase-interacting protein [IPR016818]", "Nonaspanin (TM9SF) [IPR004240]", "Nonsense-mediated mRNA decay protein 3 [IPR039722]", "Not2/Not3/Not5 [IPR040168]", "Nuclear RNA export factor [IPR030217]", "Nuclear cap-binding protein subunit 1 [IPR027159]", "Nuclear factor hnRNPA1 [IPR021662]", "Nuclear factor related to kappa-B-binding protein [IPR024867]", "Nuclear fragile X mental retardation-interacting protein 2 [IPR032747]", "Nuclear mitotic apparatus protein 1 [IPR026650]", "Nuclear polyadenylated RNA-binding protein Nab2/ZC3H14 [IPR040366]", "Nuclear pore complex protein NUP98-NUP96 [IPR037637]", "Nuclear pore complex protein Nup133-like [IPR037624]", "Nuclear pore complex protein [IPR026054]", "Nuclear pore glycoprotein p62, metazoa [IPR033072]", "Nuclear pore membrane glycoprotein 210-like [IPR045197]", "Nuclear pore protein 84/107 [IPR007252]", "Nuclear protein DGCR14/ESS-2 [IPR019148]", "Nuclear protein localization protein 4 [IPR016563]", "Nuclear speckle splicing regulatory protein 1 [IPR042816]", "Nuclear transport factor 2/Mtr2 [IPR045875]", "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 [IPR026633]", "Nucleobindin [IPR040250]", "Nucleobindin-1 [IPR040253]", "Nucleobindin-2 [IPR028813]", "Nucleolar GTP-binding protein 1 [IPR024926]", "Nucleolar GTP-binding protein 2 [IPR024929]", "Nucleolar complex protein 2 [IPR005343]", "Nucleolar complex protein 4 [IPR027193]", "Nucleolar complex-associated protein 3 [IPR016903]", "Nucleolar pre-ribosomal-associated protein 1 [IPR039844]", "Nucleolar protein 10/Enp2 [IPR040382]", "Nucleolar protein 11 [IPR042859]", "Nucleolar protein 14 [IPR007276]", "Nucleolar protein 7 [IPR039626]", "Nucleolar protein 9 [IPR040000]", "Nucleolar protein Nop56/Nop58 [IPR045056]", "Nucleolar, Nop52 [IPR010301]", "Nucleoplasmin family [IPR004301]", "Nucleoporin NSP1/NUP62 [IPR026010]", "Nucleoporin NUP88/NUP82 [IPR037700]", "Nucleoporin Nup120/160 [IPR021717]", "Nucleoporin Nup186/Nup192/Nup205 [IPR021827]", "Nucleoporin Nup188 [IPR044840]", "Nucleoporin Nup37 [IPR037626]", "Nucleoporin Nup54/Nup57/Nup44 [IPR024864]", "Nucleoporin Nup85-like [IPR011502]", "Nucleoporin Nup88 [IPR019321]", "Nucleoporin Seh1 [IPR037597]", "Nucleoporin interacting component Nup93/Nic96 [IPR007231]", "Nucleoporin p58/p45 [IPR024882]", "Nucleoporin peptidase S59-like [IPR037665]", "Nucleoporin protein Ndc1-Nup [IPR019049]", "Nucleoporin, NUP53 [IPR017389]", "Nucleoporin, Nup155-like [IPR004870]", "Nucleoside 2-deoxyribosyltransferase [IPR007710]", "Nucleoside diphosphate kinase [IPR001564]", "Nucleoside transporter ENT1/ENT2 [IPR034764]", "Nucleoside-triphosphatase, THEP1 type [IPR004948]", "Nucleosome assembly protein (NAP) [IPR002164]", "NudC domain-containing protein 1 [IPR037895]", "NudC domain-containing protein 3 [IPR027761]", "NudC family [IPR037898]", "Nurim-like [IPR033580]", "OCIA domain-containing protein 1/2 [IPR040187]", "ODR-4-like [IPR029454]", "ORC ubiquitin ligase 1 [IPR039209]", "Occludin [IPR002958]", "Oligosaccharyl transferase complex, subunit OST3/OST6 [IPR021149]", "Oligosaccharyl transferase, STT3 subunit [IPR003674]", "Optic atrophy 3-like [IPR010754]", "Origin recognition complex, subunit 2 [IPR007220]", "Origin recognition complex, subunit 3 [IPR020795]", "Origin recognition complex, subunit 5 [IPR020796]", "Ornithine aminotransferase [IPR010164]", "Orotate phosphoribosyltransferase [IPR023031]", "Orotidine 5'-phosphate decarboxylase [IPR014732]", "Oxidized purine nucleoside triphosphate [IPR003563]", "Oxysterol-binding protein [IPR000648]", "P-type ATPase [IPR001757]", "P-type ATPase subfamily IIC, subunit alpha [IPR005775]", "P-type ATPase, subfamily IIA, SERCA-type [IPR005782]", "P-type ATPase, subfamily V [IPR006544]", "P-type ATPase, subfamily IB [IPR027256]", "P-type ATPase, subfamily IIA, PMR1-type [IPR006413]", "P-type ATPase, subfamily IIB [IPR006408]", "PA2G4 family [IPR004545]", "PAT complex subunit CCDC47 [IPR012879]", "PDCD5-like [IPR002836]", "PDK/BCKDK protein kinase [IPR039028]", "PDZ and LIM domain protein 1 [IPR028537]", "PDZ domain-containing protein GIPC1/2/3 [IPR017379]", "PEST proteolytic signal-containing nuclear protein [IPR029169]", "PH-interacting protein [IPR028738]", "PHD finger protein 10 [IPR038045]", "PHF5-like [IPR005345]", "PITH domain-containing protein 1-like [IPR045099]", "Pachytene checkpoint protein 2-like [IPR044539]", "Palmitoyl protein thioesterase [IPR002472]", "Palmitoyl-protein thioesterase 1 [IPR030294]", "Pantothenate kinase, acetyl-CoA regulated, two-domain type [IPR015844]", "Paraneoplastic antigen Ma [IPR026523]", "Paraneoplastic encephalomyelitis antigen [IPR002343]", "Paraoxonase2 [IPR008364]", "Pentatricopeptide repeat domain-containing protein 3 [IPR037387]", "Peptidase A22B, signal peptide peptidase [IPR007369]", "Peptidase C13, legumain [IPR001096]", "Peptidase C1B, bleomycin hydrolase [IPR004134]", "Peptidase C2, calpain family [IPR022684]", "Peptidase C26 [IPR011697]", "Peptidase C26, gamma-glutamyl hydrolase [IPR015527]", "Peptidase C54 [IPR005078]", "Peptidase C65, otubain [IPR019400]", "Peptidase C69, dipeptidase A [IPR005322]", "Peptidase C78, ubiquitin fold modifier-specific peptidase 1/ 2 [IPR012462]", "Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930]", "Peptidase M1, aminopeptidase B [IPR015571]", "Peptidase M13 [IPR000718]", "Peptidase M14B, caboxypeptidase D [IPR015567]", "Peptidase M17, leucine aminopeptidase [IPR023042]", "Peptidase M17, leucine aminopeptidase/peptidase B [IPR011356]", "Peptidase M20 [IPR002933]", "Peptidase M24, methionine aminopeptidase [IPR001714]", "Peptidase M24A, methionine aminopeptidase, subfamily 2 [IPR002468]", "Peptidase M28 family [IPR045175]", "Peptidase M3A/M3B [IPR045090]", "Peptidase S10, serine carboxypeptidase [IPR001563]", "Peptidase S1C [IPR001940]", "Peptidase S28 [IPR008758]", "Peptidase S8, subtilisin-related [IPR015500]", "Peptidase S9A, prolyl oligopeptidase [IPR002470]", "Peptidase T1A, proteasome beta-subunit [IPR000243]", "Peptidase T2, asparaginase 2 [IPR000246]", "Peptidase family M49 [IPR039461]", "Peptidase, FtsH [IPR005936]", "Peptide chain release factor eRF1/aRF1 [IPR004403]", "Peptidyl-prolyl cis-trans isomerase FKBP2/11 [IPR044609]", "Peptidyl-prolyl cis-trans isomerase FKBP3 [IPR043368]", "Peptidyl-prolyl cis-trans isomerase FKBP4 [IPR031212]", "Peptidyl-prolyl cis-trans isomerase FKBP5 [IPR031210]", "Peptidyl-prolyl cis-trans isomerase PIN4 [IPR043323]", "Peptidyl-tRNA hydrolase, PTH2 [IPR002833]", "Pericentriolar material 1 protein [IPR024138]", "Perilipin [IPR004279]", "Periodic tryptophan protein 1 [IPR044285]", "Periodic tryptophan protein 2 [IPR027145]", "Periphilin-1 [IPR028851]", "Peroxiredoxin, AhpC-type [IPR024706]", "Peroxiredoxin-5-like [IPR037944]", "Peroxiredoxin-like 2A [IPR032802]", "Peroxiredoxin-like 2A/B/C [IPR032801]", "Peroxisomal acyl-coenzyme A oxidase [IPR034171]", "Peroxisomal membrane protein 14 [IPR025655]", "Peroxisome biogenesis factor 1 [IPR025653]", "Peroxysomal long chain fatty acyl transporter [IPR005283]", "Pescadillo [IPR010613]", "Pex19 protein [IPR006708]", "Phenylalanine-tRNA ligase, class IIc, beta subunit [IPR045060]", "Phenylalanyl-tRNA synthetase, class IIc, alpha subunit [IPR004529]", "Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archael/eukaryotic type [IPR004531]", "Phosducin-like [IPR045037]", "Phosphatidate cytidylyltransferase [IPR000374]", "Phosphatidate cytidylyltransferase, eukaryota [IPR016720]", "Phosphatidyl serine synthase [IPR004277]", "Phosphatidylethanolamine-binding protein [IPR008914]", "Phosphatidylethanolamine-binding protein, eukaryotic [IPR035810]", "Phosphatidylinositol kinase [IPR015433]", "Phosphatidylinositol transfer protein [IPR001666]", "Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma [IPR016279]", "Phosphatidylinositol-4-phosphate 5-kinase [IPR023610]", "Phosphatidylinositol-binding clathrin assembly protein [IPR030412]", "Phosphatidylinositol-glycan biosynthesis class S protein [IPR019540]", "Phosphatidylserine decarboxylase [IPR033177]", "Phosphatidylserine decarboxylase, eukaryotic type 1 [IPR033661]", "Phosphatidylserine decarboxylase-related [IPR003817]", "Phosphoacetylglucosamine mutase [IPR016657]", "Phosphodiesterase MJ0936/Vps29 [IPR000979]", "Phosphoenolpyruvate carboxykinase, GTP-utilising [IPR008209]", "Phosphoglucomutase [IPR045244]", "Phosphoglucose isomerase (PGI) [IPR001672]", "Phosphoglycerate kinase [IPR001576]", "Phosphoglycerate mutase 1 [IPR005952]", "Phosphoinositide phospholipase C family [IPR001192]", "Phospholipase B-like [IPR007000]", "Phosphoribosylformylglycinamidine cyclo-ligase [IPR004733]", "Phosphoribosylformylglycinamidine synthase PurL [IPR010073]", "Phosphoribosylglycinamide formyltransferase [IPR004607]", "Phosphoribosylglycinamide synthetase [IPR000115]", "Phosphorylated adapter RNA export protein [IPR039047]", "Phosphoserine aminotransferase [IPR022278]", "Phosphoserine phosphatase [IPR004469]", "Phosphotyrosyl phosphatase activator, PTPA [IPR004327]", "Pinin [IPR039853]", "Pirin [IPR012093]", "Plakin [IPR043197]", "Plakophilin/Delta catenin [IPR028435]", "Plasma membrane calcium-transporting ATPase 1 [IPR030320]", "Plasminogen activator inhibitor 1 RNA-binding protein [IPR027205]", "Plastin-1 [IPR030235]", "Plastin-2/3 [IPR039956]", "Plectin [IPR030269]", "Plexin family [IPR031148]", "Polo kinase kinase [IPR022165]", "Poly(A) polymerase [IPR014492]", "Poly-U binding splicing factor, PUF60-like [IPR006532]", "Polyadenylate binding protein, human types 1, 2, 3, 4 [IPR006515]", "Polyadenylate-binding protein 2 [IPR034911]", "Polyadenylate-binding protein-interacting protein 2-like [IPR040396]", "Polycomb protein EED [IPR037352]", "Polyprenyl synthetase [IPR000092]", "Polyribonucleotide 5-hydroxyl-kinase Clp1/Grc3 [IPR045116]", "Polyribonucleotide nucleotidyltransferase [IPR012162]", "Porin, eukaryotic type [IPR001925]", "Porphobilinogen deaminase [IPR000860]", "Pre-B-cell leukemia transcription factor-interacting protein 1 [IPR033589]", "Pre-mRNA-processing factor 19 [IPR038959]", "Pre-mRNA-processing factor 6/Prp1/STA1 [IPR027108]", "Pre-mRNA-processing factor Prp40 [IPR039726]", "Pre-mRNA-processing-splicing factor 8 [IPR027652]", "Pre-mRNA-splicing factor 38 [IPR005037]", "Pre-mRNA-splicing factor Cwc2/Slt11 [IPR039171]", "Pre-mRNA-splicing factor SPF27 [IPR008409]", "Pre-mRNA-splicing factor Spp2-like [IPR045166]", "Pre-mRNA-splicing factor Syf1-like [IPR045075]", "Pre-mRNA-splicing regulator WTAP [IPR033757]", "Pre-rRNA-processing protein Esf1 [IPR039754]", "Pre-rRNA-processing protein PNO1-like [IPR039912]", "Prefoldin alpha subunit, archaea-type [IPR011599]", "Prefoldin alpha-like [IPR004127]", "Prefoldin beta-like [IPR002777]", "Prefoldin subunit 2 [IPR027235]", "Prefoldin subunit 3 [IPR016655]", "Prefoldin, subunit 4 [IPR016661]", "Prenylated rab acceptor PRA1 [IPR004895]", "Prenylcysteine oxidase [IPR017046]", "Prenyltransferase subunit beta [IPR045089]", "Presenilin/signal peptide peptidase [IPR006639]", "Primosome PriB/single-strand DNA-binding [IPR000424]", "Probable ubiquitin carboxyl-terminal hydrolase FAF-X [IPR031226]", "Profilin [IPR005455]", "Profilin-1 [IPR029892]", "Profilin-2 [IPR029891]", "Profilin1/2/3, vertebrate [IPR005454]", "Prohibitin [IPR000163]", "Proliferating cell nuclear antigen, PCNA [IPR000730]", "Proline-rich AKT1 substrate 1 protein [IPR026682]", "Proline-rich protein PRCC [IPR018800]", "Proline-tRNA ligase, class IIa, archaeal-type [IPR004499]", "Prolyl 3-hydroxylase 1 [IPR039837]", "Prolyl 3-hydroxylase [IPR039575]", "Prolyl 4-hydroxylase [IPR045054]", "Prostaglandin E synthase 2 [IPR034334]", "Prostaglandin reductase 2 [IPR037399]", "Proteasome B-type subunit [IPR023333]", "Proteasome activator PA28 [IPR009077]", "Proteasome alpha-type subunit [IPR023332]", "Proteasome assembly chaperone 1 [IPR016565]", "Proteasome assembly chaperone 3 [IPR018788]", "Proteasome beta 3 subunit [IPR033811]", "Proteasome component Ecm29 [IPR024372]", "Proteasome subunit alpha 1 [IPR035144]", "Proteasome subunit alpha 3 [IPR037555]", "Proteasome subunit alpha 7 [IPR035190]", "Proteasome subunit alpha2 [IPR034644]", "Proteasome subunit alpha4 [IPR034647]", "Proteasome subunit alpha5 [IPR033812]", "Proteasome subunit alpha6 [IPR034642]", "Proteasome subunit beta 1 [IPR035202]", "Proteasome subunit beta 2 [IPR035206]", "Proteasome subunit beta 4 [IPR016295]", "Proteasome subunit beta 5 [IPR037558]", "Proteasome subunit beta 6 [IPR035140]", "Proteasome subunit beta 7 [IPR035216]", "Proteasome, subunit alpha/beta [IPR001353]", "Protein AATF/Bfr2 [IPR039223]", "Protein BRAWNIN [IPR027858]", "Protein CIP2A [IPR042510]", "Protein CUSTOS [IPR026694]", "Protein Cms1 [IPR032704]", "Protein DEK [IPR044198]", "Protein ERGIC-53 [IPR033085]", "Protein FAM210A/B-like [IPR045866]", "Protein FAM3C [IPR039219]", "Protein FRG1 [IPR010414]", "Protein ICln/Lot5/Saf5 [IPR039924]", "Protein LYRIC [IPR031402]", "Protein LZIC [IPR040065]", "Protein Lsm12-like [IPR039683]", "Protein NDRG3 [IPR030692]", "Protein Njmu-R1 [IPR028280]", "Protein PBDC1, metazoa/fungi [IPR008476]", "Protein PRRC1 [IPR026534]", "Protein PRRC2 [IPR033184]", "Protein Peter Pan-like [IPR045112]", "Protein RCC2 [IPR028641]", "Protein Red-like [IPR039896]", "Protein S100-A10 [IPR028476]", "Protein S100-A11 [IPR028482]", "Protein S100-A13 [IPR028487]", "Protein SMG8 [IPR028802]", "Protein SON [IPR032922]", "Protein Sec13 [IPR037596]", "Protein Sgt1-like [IPR044563]", "Protein Spindly, chordates [IPR028593]", "Protein TFG [IPR033512]", "Protein Yip1/4-like [IPR045231]", "Protein arginine N-methyltransferase PRMT5 [IPR007857]", "Protein arginine N-methyltransferase [IPR025799]", "Protein arginine methyltransferase NDUFAF7 [IPR003788]", "Protein canopy homolog [IPR042415]", "Protein diaphanous homologue 2 [IPR027644]", "Protein disulfide-isomerase A6-like [IPR044569]", "Protein disulphide isomerase [IPR005792]", "Protein disulphide-isomerase A4 [IPR017068]", "Protein farnesyltransferase subunit beta [IPR026872]", "Protein flightless-1 [IPR029919]", "Protein import receptor MAS20 [IPR002056]", "Protein import receptor MAS20, metazoan [IPR022422]", "Protein jagunal [IPR009787]", "Protein kinase C and casein kinase substrate in neurons protein 2 [IPR028521]", "Protein kinase C and casein kinase substrate in neurons protein 3 [IPR028523]", "Protein kinase C, delta [IPR027436]", "Protein kinase C, delta/epsilon/eta/theta types [IPR014376]", "Protein kinase Mps1 family [IPR027084]", "Protein of unknown function DUF1075 [IPR009432]", "Protein of unknown function DUF2046 [IPR019152]", "Protein of unknown function DUF2373 [IPR019327]", "Protein of unknown function DUF3512 [IPR021900]", "Protein of unknown function DUF4615 [IPR029274]", "Protein of unknown function DUF4726 [IPR031714]", "Protein of unknown function DUF719 [IPR007998]", "Protein patched/dispatched [IPR003392]", "Protein phosphatase 1 regulatory subunit 12A/B/C [IPR017401]", "Protein phosphatase 2A regulatory subunit PR55 [IPR000009]", "Protein phosphatase 2A, regulatory B subunit, B56 [IPR002554]", "Protein phosphatase 2C family [IPR015655]", "Protein phosphatase methylesterase, eukaryotic [IPR016812]", "Protein regulator of cytokinesis 1 [IPR032921]", "Protein strawberry notch [IPR026741]", "Protein suppressor of sable-like [IPR045124]", "Protein transport Sec61-beta/Sbh [IPR030671]", "Protein transport protein Got1 [IPR045176]", "Protein transport protein SEC31-like [IPR040251]", "Protein transport protein Sec23 [IPR037364]", "Protein transport protein SecG/Sec61-beta/Sbh [IPR016482]", "Protein virilizer [IPR026736]", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase [IPR000682]", "Protein-S-isoprenylcysteine O-methyltransferase [IPR025770]", "Protein-glutamate O-methyltransferase [IPR039763]", "Protein-tyrosine phosphatase, low molecular weight [IPR017867]", "Protein-tyrosine phosphatase, low molecular weight, mammalian [IPR002115]", "Protein-tyrosine phosphatase, non-receptor type-1/2 [IPR012265]", "Protein-tyrosine phosphatase, non-receptor type-6, -11 [IPR012152]", "Protein-tyrosine phosphatase-like, PTPLA [IPR007482]", "Protein/nucleic acid deglycase DJ-1 [IPR006287]", "Proteinase inhibitor I25A, stefin [IPR001713]", "Protoporphyrinogen oxidase [IPR004572]", "Pseudouridine synthase I, TruA [IPR001406]", "Pseudouridine synthase PUS1/ PUS2-like [IPR041708]", "Pseudouridine synthase, TruD [IPR001656]", "Pterin 4 alpha carbinolamine dehydratase [IPR001533]", "Pumilio homologue 3 [IPR040059]", "Purine 5'-nucleotidase [IPR016695]", "Purine nucleoside phosphorylase I, inosine/guanosine-specific [IPR011270]", "Purine nucleoside phosphorylase [IPR011268]", "Purine-rich element binding protein family [IPR006628]", "Purine-rich element-binding protein alpha [IPR030500]", "Putative RNA-binding protein 47 [IPR034442]", "Putative peptidyl-tRNA hydrolase PTRHD1 [IPR042237]", "Putative ribosome-binding factor A, mitochondrial [IPR039212]", "Pyridine nucleotide-disulphide oxidoreductase, class I [IPR001100]", "Pyridoxal phosphate-dependent decarboxylase [IPR002129]", "Pyridoxine kinase [IPR004625]", "Pyrimidine 5'-nucleotidase, eukaryotic [IPR006434]", "Pyrroline-5-carboxylate reductase [IPR000304]", "Pyruvate carboxylase [IPR005930]", "Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y [IPR017597]", "Pyruvate dehydrogenase E1 component subunit beta [IPR027110]", "Pyruvate kinase [IPR001697]", "Queuine tRNA-ribosyltransferase accessory subunit QTRTD1 [IPR028592]", "RAB11-binding protein RELCH [IPR040362]", "RINT-1/Tip20 [IPR007528]", "RLI1 [IPR013283]", "RNA (C5-cytosine) methyltransferase [IPR023267]", "RNA (C5-cytosine) methyltransferase, NOP2 [IPR023273]", "RNA 3'-terminal phosphate cyclase [IPR000228]", "RNA 3'-terminal phosphate cyclase type 1 [IPR017770]", "RNA 3'-terminal phosphate cyclase type 2 [IPR016443]", "RNA binding protein HABP4/SERBP1 [IPR039764]", "RNA cytidine acetyltransferase NAT10 [IPR033688]", "RNA demethylase ALKBH5 [IPR032860]", "RNA exonuclease 4 [IPR034920]", "RNA methyltransferase Bin3-like [IPR039772]", "RNA polymerase I associated factor, A49-like [IPR009668]", "RNA polymerase II associated factor Paf1 [IPR007133]", "RNA polymerase II transcription factor SIII, subunit A [IPR010684]", "RNA polymerase II transcriptional coactivator Sub1/Tcp4-like [IPR045125]", "RNA polymerase subunit Rpb4/RPC9 [IPR005574]", "RNA polymerase subunit Rpb7-like [IPR045113]", "RNA polymerase, Rpb8 [IPR005570]", "RNA polymerase-associated protein Ctr9 [IPR031101]", "RNA transcription, translation and transport factor protein [IPR019265]", "RNA-binding motif protein 8 [IPR008111]", "RNA-binding protein 10 [IPR033095]", "RNA-binding protein 26 [IPR034861]", "RNA-binding protein 26/27 [IPR045137]", "RNA-binding protein 45 [IPR033101]", "RNA-binding protein 5 [IPR033094]", "RNA-binding protein 6 [IPR028806]", "RNA-binding protein EWS [IPR033109]", "RNA-binding protein FUS [IPR034459]", "RNA-binding protein NOB1 [IPR039907]", "RNA-induced silencing complex, nuclease component Tudor-SN [IPR016685]", "RNA-splicing ligase RtcB homologue, eukaryotic [IPR027513]", "RNA-splicing ligase, RtcB [IPR001233]", "RNase P subunit p30 [IPR002738]", "RPA-related protein RADX [IPR040893]", "RZZ complex, subunit Zw10 [IPR009361]", "RZZ complex, subunit Zwilch [IPR018630]", "Rab GDI protein [IPR000806]", "Rab GTPase-activating protein 1 [IPR033185]", "Rab-like protein 6 [IPR040385]", "Rab21 [IPR041833]", "Rab24 [IPR041828]", "Rab3 [IPR037872]", "Rab35 [IPR041815]", "Rab3GAP catalytic subunit [IPR045700]", "Rab3GAP regulatory subunit [IPR026059]", "Rab4 [IPR041819]", "Rabaptin [IPR003914]", "Rabaptin-5 [IPR029880]", "Rad21/Rec8-like protein [IPR039781]", "Ragulator complex protein LAMTOR2-like [IPR037587]", "Ral GTPase-activating protein subunit beta [IPR039930]", "RalBP1-associated Eps domain-containing protein 1 [IPR026814]", "Ran GTPase [IPR002041]", "Ran binding protein RanBP1-like [IPR045255]", "Rap guanine nucleotide exchange factor 2 [IPR030739]", "Rap1 GTPase-GDP dissociation stimulator 1 [IPR040144]", "Ras GTPase GNL1-like [IPR043358]", "Ras GTPase-activating protein 1 [IPR028554]", "Ras GTPase-activating protein [IPR039360]", "Ras GTPase-activating protein-binding protein 1 [IPR034375]", "Ras GTPase-activating protein-binding protein 2 [IPR034377]", "Ras GTPase-activating protein-binding protein [IPR039539]", "Ras-like guanine nucleotide exchange factor [IPR008937]", "Ras-related protein Rab-23 [IPR034114]", "Ras-related protein Rab14 [IPR030702]", "Ras-related protein Ral [IPR028412]", "Ras-related protein Rap2 [IPR041840]", "Reduced folate carrier [IPR002666]", "Reduced folate transporter SLC19A1 [IPR028339]", "Remodeling and spacing factor 1-like [IPR028938]", "Remodelling complex subunit Rsc/polybromo [IPR037382]", "Renin receptor-like [IPR012493]", "Replication factor A protein 1 [IPR004591]", "Replication factor A protein 2 [IPR014646]", "Replication factor A protein 3 [IPR013970]", "Replication factor A protein-like [IPR040260]", "Replication factor C subunit 1 [IPR012178]", "Replication termination factor 2 [IPR006735]", "Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit [IPR017287]", "Retinoblastoma-binding protein 5/Swd1 [IPR037850]", "Retrieval of early ER protein Rer1 [IPR004932]", "Rho GDP/GTP exchange factor Kalirin/TRIO [IPR028570]", "Rho protein GDP-dissociation inhibitor [IPR000406]", "Rho-associated protein kinase 1/2 [IPR020684]", "Ribonuclease CAF1 [IPR006941]", "Ribonuclease H2, subunit A [IPR004649]", "Ribonuclease HII/HIII [IPR001352]", "Ribonuclease III [IPR011907]", "Ribonuclease Nob1, eukaryote [IPR017117]", "Ribonuclease T2, eukaryotic [IPR033697]", "Ribonuclease T2-like [IPR001568]", "Ribonucleases P/MRP protein subunit Pop1 [IPR039182]", "Ribonucleoprotein PTB-binding 1 [IPR034635]", "Ribonucleoside-diphosphate reductase large subunit [IPR039718]", "Ribonucleotide reductase small subunit [IPR033909]", "Ribonucleotide reductase small subunit family [IPR000358]", "Ribophorin I [IPR007676]", "Ribose-phosphate pyrophosphokinase [IPR005946]", "Ribose-phosphate pyrophosphokinase, bacterial-type [IPR037515]", "Ribosomal RNA adenine dimethylase [IPR011530]", "Ribosomal RNA adenine methyltransferase KsgA/Erm [IPR001737]", "Ribosomal RNA assembly KRR1 [IPR024166]", "Ribosomal RNA large subunit methyltransferase E [IPR015507]", "Ribosomal RNA processing protein 8 [IPR007823]", "Ribosomal RNA-processing protein 15 [IPR012459]", "Ribosomal RNA-processing protein 7 [IPR040446]", "Ribosomal RNA-processing protein Rrp9-like [IPR039241]", "Ribosomal biogenesis NSA2 family [IPR039411]", "Ribosomal biogenesis regulatory protein [IPR007023]", "Ribosomal biogenesis, methyltransferase, EMG1/NEP1 [IPR005304]", "Ribosomal protein L1 [IPR002143]", "Ribosomal protein L1, mitochondrial [IPR005879]", "Ribosomal protein L1/ribosomal biogenesis protein [IPR028364]", "Ribosomal protein L10P [IPR001790]", "Ribosomal protein L10e [IPR001197]", "Ribosomal protein L11, bacterial-type [IPR006519]", "Ribosomal protein L11/L12 [IPR000911]", "Ribosomal protein L12/P1/P2 family [IPR027534]", "Ribosomal protein L13 [IPR005822]", "Ribosomal protein L13, bacterial-type [IPR005823]", "Ribosomal protein L13, eukaryotic/archaeal [IPR005755]", "Ribosomal protein L13e [IPR001380]", "Ribosomal protein L14 [IPR039660]", "Ribosomal protein L14P [IPR000218]", "Ribosomal protein L15 [IPR030878]", "Ribosomal protein L15, bacterial-type [IPR005749]", "Ribosomal protein L15e [IPR000439]", "Ribosomal protein L18e [IPR000039]", "Ribosomal protein L19 [IPR001857]", "Ribosomal protein L2 [IPR002171]", "Ribosomal protein L2, archaeal-type [IPR023672]", "Ribosomal protein L20 [IPR005813]", "Ribosomal protein L21 [IPR001787]", "Ribosomal protein L21-like [IPR028909]", "Ribosomal protein L21e [IPR001147]", "Ribosomal protein L22, bacterial/chloroplast-type [IPR005727]", "Ribosomal protein L22/L17 [IPR001063]", "Ribosomal protein L22/L17, eukaryotic/archaeal [IPR005721]", "Ribosomal protein L22e [IPR002671]", "Ribosomal protein L23 [IPR019985]", "Ribosomal protein L24e-related [IPR000988]", "Ribosomal protein L25/L23 [IPR013025]", "Ribosomal protein L26/L24, eukaryotic/archaeal [IPR005756]", "Ribosomal protein L27 [IPR001684]", "Ribosomal protein L27/L41, mitochondrial [IPR019189]", "Ribosomal protein L27e [IPR001141]", "Ribosomal protein L28/L40, mitochondrial [IPR019192]", "Ribosomal protein L28e [IPR002672]", "Ribosomal protein L29/L35 [IPR001854]", "Ribosomal protein L29e [IPR002673]", "Ribosomal protein L3 [IPR000597]", "Ribosomal protein L3, archaeal/eukaryotic type [IPR045077]", "Ribosomal protein L3, bacterial/organelle-type [IPR019927]", "Ribosomal protein L30/YlxQ [IPR039109]", "Ribosomal protein L30e [IPR000231]", "Ribosomal protein L31e [IPR000054]", "Ribosomal protein L32e [IPR001515]", "Ribosomal protein L33 [IPR001705]", "Ribosomal protein L34Ae [IPR008195]", "Ribosomal protein L35A [IPR001780]", "Ribosomal protein L36e [IPR000509]", "Ribosomal protein L37/S30 [IPR010793]", "Ribosomal protein L37ae [IPR002674]", "Ribosomal protein L37e [IPR001569]", "Ribosomal protein L38e [IPR002675]", "Ribosomal protein L4, eukaryotic and archaeal type [IPR045240]", "Ribosomal protein L4/L1e [IPR002136]", "Ribosomal protein L44e [IPR000552]", "Ribosomal protein L47, mitochondrial [IPR010729]", "Ribosomal protein L49/IMG2 [IPR007740]", "Ribosomal protein L5 [IPR002132]", "Ribosomal protein L5 eukaryotic/L18 archaeal [IPR005485]", "Ribosomal protein L50, mitochondria [IPR018305]", "Ribosomal protein L53, mitochondrial [IPR019716]", "Ribosomal protein L6 [IPR000702]", "Ribosomal protein L7, eukaryotic [IPR005998]", "Ribosomal protein L7/L12 [IPR000206]", "Ribosomal protein L7/L30 [IPR039699]", "Ribosomal protein L7A/L8 [IPR001921]", "Ribosomal protein L7Ae/L8/Nhp2 family [IPR018492]", "Ribosomal protein L9 [IPR000244]", "Ribosomal protein P2 [IPR044076]", "Ribosomal protein S10 [IPR001848]", "Ribosomal protein S10, eukaryotic/archaeal [IPR005729]", "Ribosomal protein S11 [IPR001971]", "Ribosomal protein S12/S23 [IPR006032]", "Ribosomal protein S12e [IPR000530]", "Ribosomal protein S13 [IPR001892]", "Ribosomal protein S15 [IPR000589]", "Ribosomal protein S15, bacterial-type [IPR005290]", "Ribosomal protein S15P [IPR023029]", "Ribosomal protein S17, archaeal/eukaryotic [IPR028333]", "Ribosomal protein S17/S11 [IPR000266]", "Ribosomal protein S17e [IPR001210]", "Ribosomal protein S19/S15 [IPR002222]", "Ribosomal protein S19A/S15e [IPR005713]", "Ribosomal protein S19e [IPR001266]", "Ribosomal protein S2 [IPR001865]", "Ribosomal protein S2, bacteria/mitochondria/plastid [IPR005706]", "Ribosomal protein S2, eukaryotic [IPR027498]", "Ribosomal protein S2, eukaryotic/archaeal [IPR005707]", "Ribosomal protein S21 [IPR001911]", "Ribosomal protein S21e [IPR001931]", "Ribosomal protein S22, mitochondrial [IPR019374]", "Ribosomal protein S23, eukaryotic/archaeal [IPR005680]", "Ribosomal protein S23, mitochondrial [IPR019520]", "Ribosomal protein S23/S29, mitochondrial [IPR019368]", "Ribosomal protein S24/S35, mitochondrial [IPR039848]", "Ribosomal protein S24e [IPR001976]", "Ribosomal protein S25 [IPR004977]", "Ribosomal protein S27 [IPR000592]", "Ribosomal protein S28, mitochondrial [IPR019375]", "Ribosomal protein S28e [IPR000289]", "Ribosomal protein S29, mitochondrial [IPR008092]", "Ribosomal protein S3, eukaryotic/archaeal [IPR005703]", "Ribosomal protein S30 [IPR006846]", "Ribosomal protein S30, mitochondrial [IPR039982]", "Ribosomal protein S3Ae [IPR001593]", "Ribosomal protein S4/S9 [IPR022801]", "Ribosomal protein S4/S9, eukaryotic/archaeal [IPR005710]", "Ribosomal protein S4e [IPR000876]", "Ribosomal protein S5 [IPR000851]", "Ribosomal protein S5, eukaryotic/archaeal [IPR005711]", "Ribosomal protein S5/S7 [IPR000235]", "Ribosomal protein S5/S7, eukaryotic/archaeal [IPR005716]", "Ribosomal protein S6 kinase II [IPR016239]", "Ribosomal protein S6, eukaryotic [IPR014401]", "Ribosomal protein S6e [IPR001377]", "Ribosomal protein S7e [IPR000554]", "Ribosomal protein S8 [IPR000630]", "Ribosomal protein S8e [IPR001047]", "Ribosomal protein S8e/ribosomal biogenesis NSA2 [IPR022309]", "Ribosomal protein S9 [IPR000754]", "Ribosome assembly factor Mrt4 [IPR033867]", "Ribosome biogenesis factor, NIP7 [IPR016686]", "Ribosome biogenesis protein BRX1 [IPR026532]", "Ribosome biogenesis protein Bms1/Tsr1 [IPR039761]", "Ribosome biogenesis protein Nop16 [IPR019002]", "Ribosome biogenesis protein Rpf2 [IPR039770]", "Ribosome maturation protein Sdo1/SBDS [IPR002140]", "Ribosome maturation protein Sdo1/SBDS-like [IPR039100]", "Ribosome-binding ATPase YchF/Obg-like ATPase 1 [IPR004396]", "Ribosome-binding factor A [IPR000238]", "Ribosome-binding protein 1 [IPR040248]", "RidA family [IPR006056]", "Rieske iron-sulphur protein [IPR014349]", "RuvB-like [IPR027238]", "RuvB-like helicase 1 [IPR037938]", "RuvB-like helicase 2 [IPR037942]", "S-adenosylmethionine synthetase [IPR002133]", "S-formylglutathione hydrolase [IPR014186]", "S-phase kinase-associated protein 1 [IPR016897]", "S-phase kinase-associated protein 1-like [IPR001232]", "SAC3/GANP/THP3 [IPR045107]", "SAFB-like transcription modulator [IPR034780]", "SAP30-binding protein [IPR012479]", "SAPAP family [IPR005026]", "SCAMP [IPR007273]", "SERRATE/Ars2 [IPR039727]", "SHC SH2 domain-binding protein 1-like [IPR045140]", "SIT4 phosphatase-associated protein family [IPR007587]", "SKI-interacting protein, SKIP [IPR017862]", "SLC12A transporter family [IPR004842]", "SNF5/SMARCB1/INI1 [IPR006939]", "SNU66/SART1 family [IPR005011]", "SNX17/27/31 [IPR037831]", "SOS response associated peptidase (SRAP) [IPR003738]", "SOUL haem-binding protein [IPR006917]", "SPIN90/Ldb17 [IPR030125]", "SPRY domain-containing protein 7 [IPR035766]", "STEEP-like [IPR029704]", "SUMO-activating enzyme subunit Uba2 [IPR030661]", "SUN domain-containing protein 1 [IPR018539]", "SUN domain-containing protein 1-5 [IPR045119]", "SUN domain-containing protein 2 [IPR030272]", "SURP and G-patch domain-containing protein 1/2 [IPR040169]", "SWI/SNF complex subunit BAF57 [IPR030089]", "SWI/SNF complex subunit BRG1 [IPR030100]", "SWI/SNF complex subunit SMARCC1 [IPR030087]", "SWI/SNF complex subunit SMARCC2 [IPR038044]", "SWI/SNF-like complex subunit BAF250a [IPR030094]", "SWI/SNF-like complex subunit BAF250/Osa [IPR021906]", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [IPR038041]", "SWR1-complex protein 4/DNA methyltransferase 1-associated protein 1 [IPR027109]", "Sas10/Utp3/C1D [IPR007146]", "Scaffold attachment factor B1 [IPR034781]", "Scaffold attachment factor B2 [IPR034782]", "Scavenger mRNA decapping enzyme DcpS/DCS2 [IPR008594]", "Scc2/Nipped-B family [IPR033031]", "Schlafen family [IPR029684]", "Sda1 [IPR027312]", "Sec1-like protein [IPR001619]", "Sec13/Seh1 family [IPR037363]", "Sec20 [IPR005606]", "SecY/SEC61-alpha family [IPR002208]", "Selenophosphate synthetase [IPR004536]", "Sentrin-specific protease 3 [IPR037945]", "Sepiapterin reductase [IPR006393]", "Septin 2 [IPR008113]", "Septin 7 [IPR008115]", "Septin 9 [IPR030645]", "Septin [IPR016491]", "Serine hydroxymethyltransferase [IPR001085]", "Serine-tRNA ligase, type1 [IPR002317]", "Serine/arginine-rich splicing factor 10 [IPR034476]", "Serine/arginine-rich splicing factor 11 [IPR034447]", "Serine/arginine-rich splicing factor 6 [IPR029541]", "Serine/threonine protein phosphatase 5 [IPR011236]", "Serine/threonine-protein kinase OSR1 [IPR028749]", "Serine/threonine-protein kinase PAK2 [IPR035065]", "Serine/threonine-protein kinase TOR [IPR026683]", "Serine/threonine-protein phosphatase 2A subunit A, metazoa [IPR031090]", "Serine/threonine-protein phosphatase 4 regulatory subunit 1 [IPR031087]", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit [IPR037979]", "Serpin H1 [IPR033547]", "Serpin family [IPR000215]", "Shootin-1 [IPR024849]", "Short transmembrane mitochondrial protein 1 [IPR027854]", "Short-chain dehydrogenase/reductase SDR [IPR002347]", "Sialyltransferase [IPR012163]", "Sideroflexin-4 [IPR028825]", "Sigma intracellular receptor 2 [IPR016964]", "Signal peptidase complex subunit 3 [IPR007653]", "Signal peptidase complex subunit Spc2/SPCS2 [IPR009582]", "Signal recognition particle SRP9 [IPR039914]", "Signal recognition particle receptor, beta subunit [IPR019009]", "Signal recognition particle subunit SRP68 [IPR026258]", "Signal recognition particle, SRP14 subunit [IPR003210]", "Signal recognition particle, SRP54 subunit [IPR022941]", "Signal recognition particle, SRP54 subunit, eukaryotic [IPR006325]", "Signal recognition particle, SRP72 subunit [IPR026270]", "Signal recognition particle, SRP9 subunit [IPR008832]", "Sin3 associated polypeptide p18 [IPR010516]", "Single-stranded DNA-binding protein [IPR011344]", "Sirtuin family [IPR003000]", "Sirtuin, class I [IPR017328]", "Sister chromatid cohesion protein Pds5 [IPR039776]", "Ski3/TTC37 [IPR039226]", "Slowmo/Ups family [IPR037365]", "Sm-like protein Lsm6/SmF [IPR016487]", "Smac/DIABLO protein [IPR015142]", "Small (40S) ribosomal subunit Asc1/RACK1 [IPR045223]", "Small GTPase Rho [IPR003578]", "Small GTPase [IPR001806]", "Small GTPase superfamily, ARF type [IPR024156]", "Small GTPase superfamily, ARF/SAR type [IPR006689]", "Small GTPase superfamily, SAR1-type [IPR006687]", "Small GTPase, Ras-type [IPR020849]", "Small nuclear ribonucleoprotein E [IPR027078]", "Small nuclear ribonucleoprotein Sm D2 [IPR027248]", "Small nuclear ribonucleoprotein Sm D3 [IPR034099]", "Small-subunit processome, Utp11 [IPR007144]", "Small-subunit processome, Utp14 [IPR006709]", "Smg8/Smg9 [IPR019354]", "Smooth muscle protein/calponin [IPR003096]", "Snapin [IPR017246]", "Snapin/Pallidin/Snn1 [IPR028119]", "Snf7 family [IPR005024]", "Sodium/potassium-transporting ATPase subunit beta [IPR000402]", "Sodium/potassium-transporting ATPase subunit beta, chordates [IPR015565]", "Sodium:dicarboxylate symporter [IPR001991]", "Solute carrier family 12 member 1/2 [IPR002443]", "Solute carrier family 12 member 2 [IPR002444]", "Solute carrier family 12 member 9 [IPR030345]", "Solute carrier family 35 member SLC35F1/F2/F6 [IPR009262]", "Sorbitol dehydrogenase-like [IPR045306]", "Sorting nexin 9 family [IPR014536]", "Sorting nexin-1 [IPR028660]", "Sorting nexin-17 [IPR028666]", "Sorting nexin-2 [IPR028653]", "Sorting nexin-5 [IPR028654]", "Sorting nexin-5/6/32 [IPR014637]", "Sorting nexin-6 [IPR028657]", "Sorting nexin-9 [IPR028644]", "Spartin-like [IPR045036]", "Spectrin, beta subunit [IPR016343]", "Spermatid perinuclear RNA-binding protein [IPR030446]", "Spermidine/spermine synthase, eukaryotes [IPR030668]", "Spermidine/spermine synthases [IPR001045]", "Spermine synthase, animal [IPR015576]", "Sphingolipid delta(4)-desaturase DES1 [IPR031196]", "Sphingolipid delta4-desaturase [IPR011388]", "Sphingomyelin phosphodiesterase 4 [IPR024129]", "Spindle and kinetochore-associated protein 3 [IPR033341]", "Splicing factor 3A subunit 1 [IPR045146]", "Splicing factor 3A subunit 3 [IPR031776]", "Splicing factor 3B subunit 1-like [IPR038737]", "Splicing factor 45 [IPR040052]", "Splicing factor ELAV/Hu [IPR006548]", "Splicing factor, RBM39-like [IPR006509]", "Splicing factor, arginine/serine-rich 19 [IPR042841]", "Squalene cyclase [IPR018333]", "Squalene monooxygenase [IPR040125]", "Squalene synthase-like [IPR006449]", "Squalene/phytoene synthase [IPR002060]", "Stathmin family [IPR000956]", "Sterol O-acyltransferase, ACAT/DAG/ARE types [IPR014371]", "Sterol O-acyltransferase, metazoa [IPR030687]", "Sterol regulatory element-binding protein cleavage-activating protein [IPR030225]", "Sterol transport protein NPC2-like [IPR039670]", "Stomatin/HflK/HflC family [IPR001972]", "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 [IPR038892]", "Structural maintenance of chromosomes protein 1A, metazoan [IPR029683]", "Structural maintenance of chromosomes protein [IPR024704]", "Structure-specific recognition protein [IPR000969]", "Succinate dehydrogenase, flavoprotein subunit [IPR011281]", "Succinate dehydrogenase/fumarate reductase iron-sulphur protein [IPR004489]", "Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [IPR014006]", "Succinate semialdehyde dehydrogenase [IPR010102]", "Succinate--CoA synthetase, beta subunit [IPR005809]", "Succinyl-CoA ligase, alpha subunit [IPR005810]", "Sugar/inositol transporter [IPR003663]", "Sulfhydryl oxidase [IPR039798]", "Sulfotransferase [IPR005331]", "Sulfurtransferase TST/MPST-like [IPR045078]", "Suppressor of hairless-like [IPR040159]", "Suppressor of white apricot [IPR040397]", "Surface antigen D15-like [IPR039910]", "Surfeit locus 1/4 [IPR045214]", "Surfeit locus 4 [IPR002995]", "Surfeit locus 6 [IPR007019]", "Symplekin/Pta1 [IPR021850]", "Synaptobrevin [IPR001388]", "Synaptogyrin [IPR016579]", "Syntaxin [IPR045242]", "Syntenin-1 [IPR030528]", "Synthesis of cytochrome c oxidase, Sco1/Sco2 [IPR017276]", "T-complex protein 1, alpha subunit [IPR012715]", "T-complex protein 1, beta subunit [IPR012716]", "T-complex protein 1, delta subunit [IPR012717]", "T-complex protein 1, epsilon subunit [IPR012718]", "T-complex protein 1, eta subunit [IPR012720]", "T-complex protein 1, gamma subunit [IPR012719]", "T-complex protein 1, theta subunit [IPR012721]", "T-complex protein 1, zeta subunit [IPR012722]", "TACC family [IPR039915]", "TAF15/EWS/TLS family [IPR034870]", "TATA binding associated factor 15 [IPR034875]", "TATA element modulatory factor 1 DNA binding [IPR022092]", "TB2/DP1/HVA22-related protein [IPR004345]", "TE2IP/Rap1 [IPR039595]", "TH1 protein [IPR006942]", "THO complex subunit 2 [IPR040007]", "THO complex subunit 6 [IPR042626]", "THO complex, subunit 5 [IPR019163]", "THO complex, subunit THOC1 [IPR021861]", "THRAP3/BCLAF1 family [IPR029199]", "THUMP domain-containing protein 1-like [IPR040183]", "TIP41-like protein [IPR007303]", "TMEM14 family [IPR005349]", "TMEM192 family [IPR029399]", "TMEM33/Pom33 family [IPR005344]", "TMEM70 family [IPR009724]", "TMEM70/TMEM186/TMEM223 protein family [IPR045325]", "TMEM85/ER membrane protein complex subunit 4 [IPR009445]", "TPP-binding domain containing protein HACL1-like [IPR045025]", "TPX2 [IPR009675]", "TRAPP I complex, subunit 5 [IPR016696]", "TRAPP III complex, Trs85 [IPR024420]", "TREX component Tex1/THOC3 [IPR040132]", "Tankyrase 1-binding protein-like [IPR040006]", "Target of Myb protein 1 [IPR014645]", "TatSF1-like [IPR034393]", "Taxilin family [IPR026183]", "Telomerase RNA component interacting RNase [IPR038838]", "Telomere-associated protein Rif1 [IPR028566]", "Testin [IPR027683]", "Testis-expressed protein 10/pre-rRNA-processing protein Ipi1 [IPR037947]", "Tetrahydrofolate dehydrogenase/cyclohydrolase [IPR000672]", "Tetraspanin, animals [IPR000301]", "Tetraspanin/Peripherin [IPR018499]", "Tetratricopeptide repeat protein 19 [IPR040395]", "Tetratricopeptide repeat protein 26 [IPR030511]", "Tetratricopeptide repeat protein 38 [IPR033891]", "The Golgi pH regulator/GPCR-type G protein [IPR015672]", "ThiF/MoeB/HesA family [IPR045886]", "Thiamine pyrophosphate enzyme [IPR045229]", "Thiamine triphosphatase, eukaryotes [IPR012177]", "Thiamine-triphosphatase [IPR039582]", "Thiolase [IPR002155]", "Thioredoxin domain-containing protein 17-like [IPR045108]", "Thioredoxin-related transmembrane protein 2 [IPR039101]", "Thioredoxin/glutathione reductase selenoprotein [IPR006338]", "Threonine-tRNA ligase, class IIa [IPR002320]", "Thymidine kinase [IPR001267]", "Thymidylate kinase [IPR018094]", "Thymidylate synthase [IPR000398]", "Thymidylate synthase/dCMP hydroxymethylase [IPR045097]", "Thyroid hormone receptor-associated protein 3 [IPR026667]", "Tight junction protein ZO [IPR005417]", "Tight junction protein ZO-1 [IPR005418]", "Tight junction protein ZO-2 [IPR005419]", "Tim23-like [IPR045238]", "Tim44-like [IPR039544]", "Timeless [IPR044998]", "Tissue alpha-L-fucosidase [IPR028755]", "TmcA/NAT10/Kre33 [IPR032672]", "Tom40 [IPR037930]", "Torsin 1/2 [IPR017378]", "Torsin [IPR010448]", "Torsin-1A [IPR030549]", "Torsin-1A-interacting protein 1/2 [IPR008662]", "Torsin-1B [IPR030550]", "TraB/PrgY/GumN family [IPR002816]", "Trafficking protein particle complex subunit 2 [IPR006722]", "Trafficking protein particle complex subunit 2-like [IPR044760]", "Trans-isoprenyl diphosphate synthases, eukaryotic-type [IPR044844]", "Transaldolase type 1 [IPR004730]", "Transaldolase/Fructose-6-phosphate aldolase [IPR001585]", "Transcription elongation factor SPT5 [IPR039659]", "Transcription elongation factor Spt5, eukaryote [IPR017071]", "Transcription elongation factor Spt6 [IPR017072]", "Transcription elongation factor, IIS-type [IPR035100]", "Transcription elongation factor, TFIIS [IPR006289]", "Transcription elongation factor, mitochondrial [IPR039150]", "Transcription elongation regulator 1-like [IPR045148]", "Transcription facto Tfc3-like [IPR044210]", "Transcription factor BTF3 [IPR039370]", "Transcription factor E [IPR039997]", "Transcription factor II-I [IPR016659]", "Transcription factor IIIC subunit Tfc1/Sfc1 [IPR040454]", "Transcription factor NFX1 family [IPR034078]", "Transcription factor STAT [IPR001217]", "Transcription factor TFIIB [IPR000812]", "Transcription factor TFIIH subunit p52/Tfb2 [IPR004598]", "Transcription factor Tfc4/TFIIIC-102/Sfc4 [IPR039340]", "Transcription initiation factor IIF, beta subunit [IPR003196]", "Transcription initiation factor TFIID subunit 6 [IPR037796]", "Transcription intermediary factor 1-beta [IPR037373]", "Transcription-associated protein 1 [IPR033317]", "Transcriptional regulatory protein Sin3-like [IPR039774]", "Transcriptional regulatory protein Sin3a [IPR037969]", "Transcriptional repressor p66 [IPR040386]", "Transducin beta-like protein 2 [IPR042410]", "Transferrin receptor protein 1 [IPR029513]", "Transgelin-2 [IPR001061]", "Translation Initiation factor eIF- 4e [IPR001040]", "Translation elongation factor EF1A, eukaryotic/archaeal [IPR004539]", "Translation elongation factor EFG/EF2 [IPR004540]", "Translation elongation factor EFTs/EF1B [IPR001816]", "Translation elongation factor EFTu/EF1A, bacterial/organelle [IPR004541]", "Translation elongation factor IF5A-like [IPR001884]", "Translation initiation factor 2, alpha subunit [IPR011488]", "Translation initiation factor 2A [IPR011387]", "Translation initiation factor 3 complex subunit L [IPR019382]", "Translation initiation factor IF- 2 [IPR015760]", "Translation initiation factor IF2/IF5 [IPR045196]", "Translation initiation factor IF6 [IPR002769]", "Translation machinery-associated protein 16 [IPR021346]", "Translational activator Gcn1 [IPR033173]", "Translationally controlled tumour protein [IPR018105]", "Translin family [IPR002848]", "Translocation associated membrane protein [IPR016447]", "Translocation protein Sec62 [IPR004728]", "Translocation protein Sec63 [IPR027137]", "Translocator protein [IPR030164]", "Translocon-associated [IPR008855]", "Translocon-associated protein (TRAP), alpha subunit [IPR005595]", "Translocon-associated protein subunit gamma [IPR009779]", "Transmembrane emp24 domain-containing protein 5 [IPR015717]", "Transmembrane emp24 domain-containing protein 7 [IPR015718]", "Transmembrane emp24 domain-containing protein [IPR015720]", "Transmembrane protein 109 [IPR039492]", "Transmembrane protein 126 [IPR009801]", "Transmembrane protein 201 [IPR040041]", "Transmembrane protein 205 [IPR042623]", "Transmembrane protein 214 [IPR019308]", "Transmembrane protein 230 [IPR044234]", "Transmembrane protein 230/134 [IPR008590]", "Transmembrane protein 43 family [IPR012430]", "Transmembrane protein 65 [IPR019537]", "Transmembrane protein GPR107/GPR108-like [IPR009637]", "Transmembrane protein TqsA-like [IPR002549]", "Transport protein particle (TRAPP) component [IPR007194]", "Treacle protein [IPR017859]", "Tricarboxylate/iron carrier [IPR004686]", "Trimethyllysine dioxygenase [IPR012776]", "Triosephosphate isomerase [IPR000652]", "Triosephosphate isomerase, bacterial/eukaryotic [IPR022896]", "Tropomodulin [IPR004934]", "Tropomodulin-3 [IPR030133]", "Tropomyosin [IPR000533]", "Tryptophan-tRNA ligase [IPR002306]", "Tryptophan-tRNA ligase, bacterial-type [IPR024109]", "TspO/MBR-related protein [IPR004307]", "Tuberin [IPR003913]", "Tuberin/Ral GTPase-activating protein subunit alpha [IPR027107]", "Tubulin [IPR000217]", "Tubulin binding cofactor A [IPR004226]", "Tubulin--tyrosine ligase-like protein 12 [IPR027749]", "Tubulin-folding cofactor D [IPR033162]", "Tubulin-specific chaperone E [IPR044994]", "Tubulin-tyrosine ligase/Tubulin polyglutamylase [IPR004344]", "Tumour protein D52 [IPR007327]", "Twinfilin [IPR028458]", "Twinkle-like protein [IPR027032]", "Type 1 protein exporter [IPR039421]", "Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase [IPR002591]", "Type II pantothenate kinase [IPR004567]", "Type II phosphatidylinositol 4-kinase Lsb6/PI4K2 [IPR039756]", "Tyrosine-tRNA ligase [IPR002307]", "Tyrosine-tRNA ligase, bacterial-type [IPR024088]", "Tyrosine/threonine-protein kinase, Cdc2 inhibitor [IPR016235]", "U1 small nuclear ribonucleoprotein C [IPR017340]", "U2 auxiliary factor small subunit [IPR009145]", "U2 small nuclear ribonucleoprotein A' [IPR044640]", "U2 snRNP auxilliary factor, large subunit, splicing factor [IPR006529]", "U3 small nucleolar RNA-associated protein 10 [IPR040191]", "U3 small nucleolar RNA-associated protein 18 [IPR045161]", "U3 small nucleolar RNA-associated protein 25 [IPR010678]", "U3 small nucleolar RNA-associated protein 6 [IPR013949]", "U3 small nucleolar ribonucleoprotein complex, subunit Mpp10 [IPR012173]", "U3 snoRNP protein/Ribosome production factor 1 [IPR044281]", "U4/U6 small nuclear ribonucleoprotein Prp3 [IPR027104]", "U4/U6 small nuclear ribonucleoprotein Prp31 [IPR027105]", "U6 snRNA-associated Sm-like protein LSm2 [IPR016654]", "UAA transporter [IPR013657]", "UBAP2/protein lingerer [IPR022166]", "UBX domain-containing protein 2/7 [IPR017346]", "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110kDa subunit [IPR037919]", "UDP-glucose 6-dehydrogenase, eukaryotic type [IPR028356]", "UDP-glucose/GDP-mannose dehydrogenase [IPR017476]", "UDP-glucose:Glycoprotein Glucosyltransferase [IPR009448]", "UDP-sugar pyrophosphorylase [IPR039741]", "UDPGP family [IPR002618]", "UHRF1/2-like [IPR045134]", "UMP-CMP kinase [IPR006266]", "USP39 [IPR033809]", "UTP--glucose-1-phosphate uridylyltransferase [IPR016267]", "UV excision repair protein Rad23 [IPR004806]", "Ubiquilin-1/2 [IPR028430]", "Ubiquinol-cytochrome c chaperone, CBP3 [IPR007129]", "Ubiquinol-cytochrome c chaperone/UPF0174 [IPR021150]", "Ubiquitin binding protein, Hrs/VPS27 [IPR017073]", "Ubiquitin carboxyl-terminal hydrolase 10 [IPR028767]", "Ubiquitin carboxyl-terminal hydrolase 14-like [IPR044635]", "Ubiquitin conjugation factor E4 [IPR045132]", "Ubiquitin fusion degradation protein Ufd1-like [IPR004854]", "Ubiquitin thioesterase OTUB1 [IPR030298]", "Ubiquitin thioesterase Otubain [IPR016615]", "Ubiquitin thioesterase otulin [IPR023237]", "Ubiquitin-activating enzyme E1 [IPR018075]", "Ubiquitin-fold modifier-conjugating enzyme 1 [IPR014806]", "Ubiquitin-like modifier Hub1/Ubl5 [IPR039732]", "Ubiquitin-like-conjugating enzyme Atg3/Atg10 [IPR007135]", "Ubiquitin-protein ligase E3A [IPR017134]", "Ubiquitin-protein ligase E3B/C [IPR044611]", "Ubiquitin-specific peptidase 24 [IPR033382]", "Ubiquitin/SUMO-activating enzyme E1 [IPR000011]", "Ubiquitinyl hydrolase [IPR016652]", "Ubiquitinyl hydrolase, UCH37 type [IPR017390]", "Uncharacterised conserved protein UCP013899, metal binding [IPR016617]", "Uncharacterised protein family UPF0449 [IPR028227]", "Uncharacterized protein KIAA2013-like [IPR018795]", "Uracil-DNA glycosylase family 1 [IPR002043]", "Ureohydrolase [IPR006035]", "Uridine kinase-like [IPR000764]", "Uridine-cytidine kinase 2 [IPR029925]", "Uroporphyrinogen decarboxylase HemE [IPR006361]", "V-type ATPase, V0 complex, 116kDa subunit family [IPR002490]", "V-type ATP synthase catalytic alpha chain [IPR022878]", "V-type ATP synthase regulatory subunit B/beta [IPR022879]", "V-type ATPase subunit E [IPR002842]", "V0 complex accessory subunit Ac45 [IPR008388]", "VPRBP/DCAF1 family [IPR033270]", "Vacuolar fusion protein Ccz1 [IPR013176]", "Vacuolar import/degradation protein Vid24 [IPR018618]", "Vacuolar protein sorting protein 26 related [IPR028934]", "Vacuolar protein sorting-associated protein 13 [IPR026847]", "Vacuolar protein sorting-associated protein 16 [IPR016534]", "Vacuolar protein sorting-associated protein 29 [IPR028661]", "Vacuolar protein sorting-associated protein 33 [IPR027121]", "Vacuolar protein sorting-associated protein 35 [IPR005378]", "Vacuolar protein sorting-associated protein 4 [IPR031255]", "Vacuolar protein sorting-associated protein 51 [IPR014812]", "Vacuolar protein sorting-associated protein 53 [IPR039766]", "Vacuolar protein sorting-associated protein 9-like [IPR045046]", "Vacuolar protein sorting-associated protein Ist1 [IPR005061]", "Vacuolar protein-sorting protein Bro1-like [IPR045251]", "Valine-tRNA ligase [IPR002303]", "Vang-like protein [IPR009539]", "Vesicle transport protein, Got1/SFT2-like [IPR007305]", "Vesicle-associated membrane-protein-associated protein [IPR016763]", "Vesicle-fusing ATPase [IPR039812]", "Vesicle-trafficking protein Sec22 [IPR044565]", "Vezatin [IPR026858]", "Villin/Gelsolin [IPR007122]", "Vimentin [IPR027699]", "Vinculin [IPR017997]", "Vinculin/alpha-catenin [IPR006077]", "Vitamin K epoxide reductase complex subunit 1 [IPR042406]", "Vitamin K-dependent gamma-carboxylase [IPR007782]", "Voltage-dependent anion-selective channel protein 1 [IPR030270]", "Voltage-dependent anion-selective channel protein 2 [IPR030277]", "Voltage-dependent anion-selective channel protein 3 [IPR030271]", "WD repeat BOP1/Erb1 [IPR028598]", "WD repeat Prp46/PLRG1-like [IPR045241]", "WD repeat WDR12/Ytm1 [IPR028599]", "WD repeat domain phosphoinositide-interacting protein 2 [IPR032911]", "WD repeat-containing protein 41 [IPR040102]", "WD repeat-containing protein 73 [IPR042795]", "WD repeat-containing protein DCAF7-like [IPR045159]", "WD repeat-containing protein WDR18/Ipi3/RID3 [IPR045227]", "WD repeat-containing protein WDR46/Utp7 [IPR040315]", "WD40 repeat-containing protein SMU1 [IPR045184]", "WDR74/Nsa1 [IPR037379]", "WW domain binding protein 11 [IPR019007]", "WW domain-binding protein 2 [IPR033598]", "WW domain-binding protein 2-like [IPR044852]", "Wings apart-like protein [IPR039874]", "Wolframin [IPR026208]", "Wolframin family [IPR026209]", "XMAP215 family [IPR045110]", "XPA [IPR000465]", "XPG/Rad2 endonuclease [IPR006084]", "Xaa-Arg dipeptidase [IPR017144]", "YAP-binding/ALF4/Glomulin [IPR013877]", "YLP motif-containing protein 1 [IPR026314]", "YTH domain containing protein [IPR045168]", "YgfZ/GcvT [IPR045179]", "Yif1 family [IPR005578]", "YjeF N-terminal domain-containing protein NAXE-like [IPR032976]", "YjgF/YER057c/UK114 family [IPR006175]", "ZPR1 family [IPR040141]", "ZZ-type zinc finger-containing protein 3 [IPR037830]", "Zinc finger CCCH domain-containing protein A/B [IPR039691]", "Zinc finger CCHC domain-containing protein 3 [IPR042509]", "Zinc finger FYVE domain containing protein, SARA/endofin [IPR035438]", "Zinc finger FYVE domain-containing protein, endofin [IPR017165]", "Zinc finger protein 638 [IPR033096]", "Zinc transporter 9 [IPR040177]", "Zinc transporter Msc2-like [IPR045316]", "Zinc/iron permease [IPR003689]", "cAMP-dependent protein kinase catalytic subunit [IPR044109]", "cAMP-dependent protein kinase regulatory subunit [IPR012198]", "dCTP pyrophosphatase 1 [IPR025984]", "dTDP-4-dehydrorhamnose reductase family [IPR005913]", "hnRNP A2/B1 [IPR034489]", "mRNA 3'-end-processing protein Rna14-like [IPR045243]", "mRNA cap guanine-N7 methyltransferase [IPR039753]", "mRNA cap guanine-N7 methyltransferase, eukaryotes [IPR016899]", "mRNA export factor Gle2/RAE1 [IPR037631]", "mRNA splicing factor Cwf18-like [IPR013169]", "mRNA-decapping enzyme subunit 1 [IPR010334]", "p53 tumour suppressor family [IPR002117]", "rRNA biogenesis protein RRP36 [IPR009292]", "rRNA biogenesis protein Rrp5 [IPR045209]", "tRNA (C5-cytosine) methyltransferase, NCL1 [IPR023270]", "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 [IPR017423]", "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit [IPR028884]", "tRNA (guanine-N-7) methyltransferase catalytic subunit Trm8, eukaryote [IPR025763]", "tRNA (guanine-N-7) methyltransferase, Trmb type [IPR003358]", "tRNA (guanine-N1-)-methyltransferase, eukaryotic [IPR007356]", "tRNA (uracil(54)-C(5))-methyltransferase, eukaryotic type [IPR045850]", "tRNA N6-adenosine threonylcarbamoyltransferase Kae1, archaea and eukaryote [IPR034680]", "tRNA guanosine-2'-O-methyltransferase, TRM11 [IPR016691]", "tRNA methyltransferase 10 homologue C [IPR025812]", "tRNA methyltransferase, Trm1 [IPR002905]", "tRNA modification GTPase MnmE [IPR004520]", "tRNA pseudouridine synthase B family [IPR004802]", "tRNA pseudouridine synthase II, TruB [IPR014780]", "tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase MiaB [IPR006463]", "tRNA-specific 2-thiouridylase [IPR004506]"], "available_proteins": ["AAAS", "AAR2", "AARS", "AARS2", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABHD12", "ACAA1", "ACAA2", "ACADM", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACTL6A", "ACTR10", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADA", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFG3L2", "AGL", "AGPS", "AHCY", "AHCYL1", "AHSA1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "AKT1S1", "ALCAM", "ALDH18A1", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALG9", "ALKBH5", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANKLE2", "ANKRD13A", "ANO10", "ANO6", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APC", "APEX1", "API5", "APOO", "APOOL", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFIP1", "ARG2", "ARHGDIA", "ARID1A", "ARID4B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARL6", "ARL6IP1", "ARL6IP5", "ARL8B", "ARMC1", "ARMC6", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC1", "ASF1A", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD2", "ATAD3A", "ATAD3B", "ATG13", "ATG3", "ATG4B", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATP7B", "ATPAF1", "ATPIF1", "ATXN2", "ATXN2L", "AURKA", "B3GALT6", "B4GAT1", "BABAM2", "BAG2", "BAG5", "BAIAP2", "BANF1", "BASP1", "BCAP31", "BCAS2", "BCCIP", "BCKDK", "BCL10", "BCL2L13", "BCLAF1", "BEND3", "BICD2", "BIRC6", "BLMH", "BLOC1S1", "BLVRA", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPNT1", "BRAT1", "BRCA1", "BRD7", "BRIX1", "BSG", "BTF3", "BUB1B", "BUD23", "BUD31", "BYSL", "C12orf43", "C12orf73", "C17orf75", "C19orf25", "C19orf70", "C1QBP", "C1orf122", "C1orf123", "C1orf35", "C2CD5", "C5orf15", "C7orf50", "C8orf33", "CAB39", "CAD", "CALD1", "CALR", "CALU", "CAMSAP3", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CAST", "CBFB", "CBR1", "CBX3", "CC2D1A", "CCAR1", "CCAR2", "CCDC12", "CCDC124", "CCDC127", "CCDC138", "CCDC22", "CCDC47", "CCDC6", "CCDC8", "CCDC86", "CCDC93", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CCZ1B", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC37", "CDC42", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK5RAP1", "CDK5RAP3", "CDK7", "CDKAL1", "CDR2L", "CDS2", "CEBPZ", "CELF2", "CEP170", "CEP290", "CEP44", "CETN2", "CFAP20", "CFL1", "CFL2", "CGGBP1", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1L", "CHD8", "CHERP", "CHMP1A", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHST14", "CIAPIN1", "CIP2A", "CISD1", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT3", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COASY", "COG3", "COG7", "COG8", "COIL", "COLGALT1", "COMMD1", "COMMD4", "COMMD7", "COMT", "COMTD1", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "COQ8A", "CORO1C", "COTL1", "COX11", "COX14", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7A2L", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF2", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRNKL1", "CRTAP", "CS", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUL7", "CUTA", "CWF19L1", "CXorf56", "CXorf57", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DCAF1", "DCAF7", "DCAKD", "DCD", "DCP1B", "DCPS", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D5", "DCXR", "DDAH2", "DDB1", "DDOST", "DDRGK1", "DDX54", "DEGS1", "DEK", "DENR", "DERL1", "DFFA", "DGCR8", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHRS7", "DHRS7B", "DHTKD1", "DHX29", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DIDO1", "DIEXF", "DKC1", "DLAT", "DLD", "DLG1", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJC10", "DNAJC13", "DNAJC2", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOCK7", "DOHH", "DOLPP1", "DPH2", "DPM1", "DPP3", "DPYSL2", "DR1", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYM", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC4", "EED", "EEF1A2", "EEF1E1", "EEF1G", "EFHD2", "EHD1", "EHD4", "EHHADH", "EHMT1", "EHMT2", "EIF2A", "EIF2B1", "EIF2B2", "EIF2B4", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC3", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "ENDOD1", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERC1", "ERCC3", "ERGIC1", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESS2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC4", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC8", "EXOSC9", "EZR", "F11R", "FADS2", "FAH", "FAM114A2", "FAM120A", "FAM129B", "FAM162A", "FAM177A1", "FAM210A", "FAM213A", "FAM3C", "FAM49B", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP2", "FARSA", "FARSB", "FAU", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FH", "FHL1", "FHOD1", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKRP", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FNBP1", "FNTB", "FRG1", "FSCN1", "FTL", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALK1", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GCAT", "GCFC2", "GCLC", "GCN1", "GDAP1", "GDI1", "GDI2", "GEMIN4", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GGPS1", "GHDC", "GHITM", "GID4", "GINS1", "GINS2", "GINS3", "GINS4", "GIPC1", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GM2A", "GMFB", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAO1", "GNL1", "GNL2", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLPH3", "GOLT1B", "GORASP2", "GOSR1", "GOSR2", "GOT1", "GOT2", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR89B", "GPRASP2", "GPS1", "GPT2", "GPX8", "GRPEL1", "GRSF1", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2H4", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD2", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAT1", "HAUS1", "HAUS2", "HAUS4", "HAUS5", "HAX1", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDHD2", "HDHD3", "HDHD5", "HEATR1", "HEBP1", "HECTD1", "HELZ", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB3", "HMGCL", "HMGCR", "HMGCS1", "HMGN1", "HMGXB4", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPC", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUS1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IGF2BP2", "IK", "IKBIP", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INCENP", "INF2", "INPP4A", "INTS1", "INTS10", "INTS12", "INTS14", "INTS3", "INTS8", "IPO4", "IPO5", "IRGQ", "IRS4", "ISCU", "IST1", "ISYNA1", "ITGAV", "ITGB1", "ITPA", "ITPRIP", "IVD", "JAGN1", "JPT2", "JUP", "KARS", "KDELR1", "KDM1A", "KDM3B", "KDSR", "KHDRBS1", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1468", "KIAA2013", "KIF14", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC4", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LCMT2", "LDAH", "LDB1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMF2", "LNPEP", "LNPK", "LONP1", "LRPAP1", "LRPPRC", "LRRC47", "LSM12", "LSM2", "LSM4", "LSM6", "LSS", "LTA4H", "LTV1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LZIC", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAK16", "MAN1A1", "MAN1A2", "MANF", "MAP1B", "MAP1S", "MAP3K7", "MAP4", "MAP7D1", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARS", "MAT2A", "MAT2B", "MAVS", "MBD3", "MBOAT7", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED14", "MED16", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METAP2", "METTL1", "METTL3", "MFAP1", "MFF", "MFN2", "MFSD10", "MFSD5", "MFSD8", "MGEA5", "MGST2", "MGST3", "MICU1", "MICU2", "MID1", "MIEF1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MLEC", "MMAB", "MMGT1", "MMS19", "MOGS", "MORF4L1", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPI", "MPST", "MPV17L2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL27", "MRPL3", "MRPL33", "MRPL37", "MRPL38", "MRPL4", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL9", "MRPS11", "MRPS15", "MRPS17", "MRPS2", "MRPS21", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTBP", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTOR", "MTR", "MTX1", "MTX2", "MVD", "MXRA7", "MYBBP1A", "MYCBP", "MYDGF", "MYEF2", "MYG1", "NAA10", "NAA15", "NAA25", "NAA40", "NADK2", "NAE1", "NAF1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NAT10", "NAXE", "NBN", "NCAPD2", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCDN", "NCKAP1", "NCKIPSD", "NCLN", "NCSTN", "ND5", "NDC1", "NDRG3", "NDUFA13", "NDUFA4", "NDUFAF3", "NDUFAF7", "NDUFB10", "NDUFB11", "NDUFB4", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS5", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEDD4L", "NEFL", "NEFM", "NELFB", "NELFCD", "NELFE", "NES", "NF1", "NFRKB", "NFS1", "NFXL1", "NHP2", "NIP7", "NIPBL", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL9", "NOP10", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRM", "NRP1", "NSA2", "NSF", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDCD3", "NUDT1", "NUDT19", "NUDT21", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NXF1", "OAT", "OCIAD1", "OCLN", "ODR4", "OGDH", "OGT", "OLA1", "OPA1", "OPA3", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAIP2", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARN", "PBDC1", "PBRM1", "PBXIP1", "PC", "PCBD1", "PCID2", "PCK2", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD5", "PDCD6IP", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDS5A", "PDS5B", "PDSS2", "PDXDC1", "PDXK", "PEBP1", "PECR", "PES1", "PEX1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PHAX", "PHB", "PHB2", "PHF10", "PHF5A", "PHGDH", "PHIP", "PHPT1", "PI4K2A", "PI4KA", "PICALM", "PIGG", "PIGK", "PIGS", "PIGT", "PIK3C2A", "PIN4", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PKM", "PKMYT1", "PLA2G15", "PLBD2", "PLCG1", "PLEC", "PLIN3", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNMA8A", "PNN", "PNO1", "PNP", "PNPT1", "POFUT1", "POLA1", "POLD1", "POLD2", "POLE", "POLE2", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR2L", "POLR3A", "POLR3C", "POLR3E", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPFIA1", "PPHLN1", "PPIH", "PPIL1", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1R12A", "PPP1R14B", "PPP1R9B", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP5C", "PPP6R3", "PPT1", "PPT2", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX5", "PRDX6", "PREB", "PRELID3B", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF40A", "PRPF6", "PRPF8", "PRPS1", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PSAT1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSMG1", "PSMG3", "PSPH", "PTBP1", "PTBP2", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTRH2", "PTRHD1", "PUF60", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RABAC1", "RABEP1", "RABGAP1", "RABGEF1", "RABGGTA", "RABL6", "RAC1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALGAPB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RAP1GDS1", "RAP2B", "RAPGEF2", "RARS", "RASA1", "RAVER1", "RBBP5", "RBBP6", "RBFA", "RBM10", "RBM17", "RBM22", "RBM26", "RBM27", "RBM39", "RBM45", "RBM47", "RBM5", "RBM6", "RBM8A", "RBPJ", "RCC2", "RCL1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REPS1", "RER1", "REXO4", "RFC1", "RHOA", "RHOT2", "RIDA", "RIF1", "RINT1", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF219", "RNF40", "RNMT", "RNPEP", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPA3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS27", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCA", "RTCB", "RTFDC1", "RTRAF", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SAE1", "SAFB", "SAFB2", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SARS", "SARS2", "SART1", "SBDS", "SBNO1", "SCAF1", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCAP", "SCARB1", "SCARB2", "SCD", "SCFD1", "SCO1", "SCO2", "SCPEP1", "SCRN1", "SCRN3", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETDB1", "SF1", "SF3A1", "SF3A3", "SF3B1", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SH3GL1", "SH3GLB1", "SHCBP1", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIN3A", "SIN3B", "SIRT1", "SIRT2", "SKA3", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC2A8", "SLC30A5", "SLC30A9", "SLC35A4", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC44A1", "SLC4A7", "SLC7A1", "SLC9A3R1", "SLFN11", "SLK", "SLTM", "SMARCA4", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMCHD1", "SMG5", "SMG8", "SMPD4", "SMS", "SMU1", "SNAPIN", "SND1", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX2", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPART", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPDL1", "SPECC1L", "SPR", "SPRYD7", "SPTBN1", "SPTBN2", "SQLE", "SRFBP1", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPRB", "SRRT", "SRSF10", "SRSF11", "SRSF6", "SSB", "SSBP1", "SSR1", "SSR3", "SSR4", "SSRP1", "ST3GAL4", "STAG1", "STAG2", "STAT1", "STAT3", "STIP1", "STMN1", "STOML2", "STRBP", "STRIP1", "STT3A", "STT3B", "STUB1", "STX10", "STX12", "STX4", "STX5", "STX6", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SURF4", "SURF6", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TAB1", "TACC3", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TARS", "TARS2", "TARSL2", "TBCA", "TBCD", "TBCE", "TBL2", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TECR", "TEFM", "TERF2IP", "TES", "TEX10", "TFB1M", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THTPA", "THUMPD1", "TIGAR", "TIMELESS", "TIMM13", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIPRL", "TJP1", "TJP2", "TK1", "TKFC", "TM9SF2", "TM9SF3", "TM9SF4", "TMA16", "TMBIM6", "TMCO1", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM126B", "TMEM14C", "TMEM192", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM230", "TMEM245", "TMEM33", "TMEM43", "TMEM65", "TMEM70", "TMEM87A", "TMEM97", "TMF1", "TMLHE", "TMOD3", "TMX2", "TNKS1BP1", "TNPO1", "TOE1", "TOM1", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM6", "TOP1", "TOP2A", "TOP2B", "TOR1A", "TOR1AIP1", "TOR1AIP2", "TOR1B", "TP53", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP2", "TPT1", "TPX2", "TRABD", "TRAM1", "TRAP1", "TRAPPC2L", "TRAPPC3", "TRAPPC5", "TRAPPC8", "TRIM28", "TRIO", "TRIP10", "TRIP12", "TRIP13", "TRIP4", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSC2", "TSFM", "TSNAX", "TSPAN3", "TSPAN6", "TSPO", "TSPYL1", "TSR1", "TSR3", "TTC19", "TTC26", "TTC37", "TTC38", "TTK", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBG1", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC9", "TXNL4A", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2", "UBAP2L", "UBE3A", "UBE3C", "UBE4A", "UBL5", "UBQLN2", "UBR4", "UBR7", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UFSP2", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNG", "UPF1", "UPF3B", "UQCC1", "UQCR10", "UQCRB", "UQCRFS1", "UQCRQ", "URB1", "UROD", "USMG5", "USP10", "USP14", "USP24", "USP39", "USP5", "USP9X", "UTP11", "UTP14A", "UTP18", "UTP3", "UTP6", "UTRN", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VEZT", "VIM", "VIRMA", "VKORC1L1", "VPS13A", "VPS13C", "VPS16", "VPS25", "VPS26A", "VPS26B", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4A", "VPS4B", "VPS51", "VPS53", "WAPL", "WARS", "WARS2", "WBP11", "WBP2", "WDR12", "WDR18", "WDR4", "WDR41", "WDR46", "WDR73", "WDR74", "WDR76", "WDR82", "WFS1", "WIPI2", "WTAP", "XAB2", "XPA", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YIF1A", "YIF1B", "YIPF4", "YLPM1", "YME1L1", "YTHDC1", "YTHDF2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H14", "ZC3H4", "ZC3H7B", "ZCCHC3", "ZFYVE16", "ZMPSTE24", "ZNF326", "ZNF598", "ZNF638", "ZPR1", "ZW10", "ZWILCH", "ZZZ3"], "leading_proteins": ["ABCB7", "ACOX1", "ACP6", "AFG3L2", "AK4", "AKAP8L", "ALG12", "ANO10", "ANP32B", "APOO", "ATAD3A", "ATP13A1", "ATP1A1", "ATP1B1", "ATP2A2", "ATP2B1", "ATP2C1", "ATP6V0A1", "ATP7A", "ATP7B", "CCAR2", "CCDC8", "CLPTM1L", "CLTA", "CNNM4", "CPNE3", "CPSF7", "CPT2", "CPVL", "CYP20A1", "DHRS7", "DNAJA2", "DNAJA3", "DYNC1LI1", "ELAVL1", "ERAP1", "ERLIN2", "EXOSC3", "FLOT1", "FUCA1", "FUS", "FXR2", "GAPVD1", "GGPS1", "GNA13", "GNAI1", "GNAI2", "GNAO1", "HEXA", "HK2", "HMOX2", "HNRNPC", "HS2ST1", "HSD17B12", "HSDL1", 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b/interpro_homologous_superfamily/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..5c3d519d194c2f342eee04d08ead428c04299968 --- /dev/null +++ b/interpro_homologous_superfamily/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:5a2b3ccba797f08a6944eee7644389232838a26bf75f0a4517e1d48ea0c51a26 +size 133936 diff --git a/interpro_homologous_superfamily/df_merge.tsv b/interpro_homologous_superfamily/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..f2a30bdd41a6530b223b2111060a6aca354183c9 --- /dev/null +++ b/interpro_homologous_superfamily/df_merge.tsv @@ -0,0 +1,21 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Mitochondrial carrier domain superfamily [IPR023395] 16 19 3.202275118127538 0.0013634671142808 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 1.3618089061616092e-06 0.1644315705571846 0.0513963234576887 0.002055769463525 1.1521546305420906e-06 +Alpha/Beta hydrolase fold [IPR029058] 11 25 3.1095185917385244 0.0018739249076147 7.793689320388349 25.487864077669904 0.3803730368869525 0.1931612116461074 2.8504230618688027 2.5849355029363217 1.9090082785106757 0.2379814650369476 9.554899159960085e-06 0.0395283360833688 4.202207334542924e-05 4.125356967472877e-06 7.825314737739928e-05 +Glycoside hydrolase superfamily [IPR017853] 8 15 2.787438810180193 0.0053126486296897 7.094660194174757 15.565533980582524 0.5992585613623983 0.1928722204186086 2.565315823223627 1.245604487832095 1.9386029676344616 0.2695693578719223 3.472776208258202e-07 1.0 1.0 0.0032545859437725 2.07553330550362e-06 +P-type ATPase, A domain superfamily [IPR008250] 7 8 2.7360476652840746 0.0062182018272194 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 1.387816695443604e-05 1.0 1.0 0.0152248647419399 5.100313122590283e-06 +P-type ATPase, cytoplasmic domain N [IPR023299] 7 8 2.7360476652840746 0.0062182018272194 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 1.387816695443604e-05 1.0 1.0 0.0152248647419399 5.100313122590283e-06 +P-type ATPase, transmembrane domain superfamily [IPR023298] 7 8 2.7360476652840746 0.0062182018272194 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 1.9281545264565708e-05 1.0 1.0 0.0172025832638257 7.490488694519441e-06 +HAD-like superfamily [IPR036412] 10 21 2.50752949718454 0.0121578433613458 5.905339805825243 19.805825242718445 0.5764874318568468 0.4905542596212732 2.7813998415737995 2.7290535093395536 0.8549369097345116 0.3043048374614219 0.0022385611820026 1.0 0.4407605172427877 0.0564393829037643 0.0001244263791846 +HAD superfamily [IPR023214] 10 21 2.50752949718454 0.0121578433613458 5.905339805825243 19.805825242718445 0.5764874318568467 0.4905542596212732 2.7813998415737995 2.7290535093395536 0.8549369097345116 0.3043048374614219 0.0014241522214034 1.0 0.4186050092003007 0.0457432535763689 6.44525697009205e-05 +Histidine phosphatase superfamily [IPR029033] 1 6 2.260587556270465 0.023784809026955 1.1262135922330097 5.514563106796117 0.7684120115144248 0.3501978831807532 1.087703661549979 0.6771453167512235 0.986671075305162 0.2738673806375665 0.1419136078203099 0.0028214739728005 0.0113213926532688 0.0621585272883563 0.1985866733922443 +Tubulin/FtsZ, GTPase domain superfamily [IPR036525] 5 8 2.239458624262987 0.0251260905899621 3.7524271844660193 6.847087378640777 0.510735400099038 0.3891602594566672 2.000453572849188 1.1755668998633355 1.2190917823770269 0.3170422836523225 0.0006679426562608 1.0 1.0 0.3715199079432311 0.0017429018144962 +LEM/LEM-like domain superfamily [IPR011015] 4 6 2.1599450062333303 0.030776927092343 2.237864077669903 5.759708737864078 0.8787481060627674 0.3228260833428172 1.2758866328838632 0.4653299410110203 1.033781091163317 0.2887768895441466 3.287944493314721e-05 1.0 1.0 0.0081566962170519 1.5236816634742336e-06 +Immunoglobulin-like domain superfamily [IPR036179] 8 13 2.116601952687457 0.0342936442633112 4.480582524271845 12.427184466019416 0.4075261998509777 0.4433674298264088 2.6479725987944898 3.173316973839475 1.1756568118942026 0.3233613924696422 0.6661680865289195 1.0 1.0 0.7700300254631364 0.8160819690349158 +FAD/NAD(P)-binding domain superfamily [IPR036188] 9 18 2.103290841670821 0.0354403535297656 5.128640776699029 19.483009708737864 1.1388517428876976 0.3148047818604211 2.42568278788952 1.8971625900564304 0.9268276914308484 0.2996934003616133 0.017409601938399 0.1683799151698467 0.0538434207197609 0.0671599559498881 0.0390278099301106 +Tubulin/FtsZ-like, C-terminal domain [IPR037103] 5 7 2.0895229346523223 0.0366606756361753 3.6140776699029127 5.883495145631068 0.537603280896448 0.3771225437200781 1.6631634011190108 1.117390952728082 1.2199662970774952 0.3090115161057067 0.0002765798097399 1.0 1.0 0.3236592382947187 0.0007388687073799 +Tubulin/FtsZ, C-terminal [IPR008280] 5 7 2.0895229346523223 0.0366606756361753 3.6140776699029127 5.883495145631068 0.537603280896448 0.3771225437200781 1.6631634011190108 1.117390952728082 1.2199662970774952 0.3090115161057067 0.000508394757649 1.0 1.0 0.3559534457378639 0.0013369974246366 +Tubulin, C-terminal [IPR023123] 5 7 2.0895229346523223 0.0366606756361753 3.6140776699029127 5.883495145631068 0.537603280896448 0.3771225437200781 1.6631634011190108 1.117390952728082 1.2199662970774952 0.3090115161057067 0.000508394757649 1.0 1.0 0.3559534457378639 0.0013369974246366 +EF-hand domain pair [IPR011992] 19 48 2.087301562160325 0.0368608836714499 13.3252427184466 49.37378640776699 0.9065364020670126 0.4404331516970506 4.9772339658485505 4.730718887980642 1.169914018421813 0.3730081256676846 0.0111495721659109 0.1200428680404904 0.1231026090672371 0.3673553326047718 0.0203675612264561 +Band 7/SPFH domain superfamily [IPR036013] 6 7 1.9746404883921191 0.0483089608858686 3.825242718446602 7.354368932038835 0.2848798017769268 0.3662852929750465 1.8717479731706237 0.7075565364256523 1.25010454777189 0.3076860385713043 0.0560883044213639 1.0 1.0 0.2167775624926856 0.0105668672564949 +Metalloenzyme, LuxS/M16 peptidase-like [IPR011249] 2 7 1.9673585519977208 0.0491418891833179 2.6067961165048543 7.0 0.7914914082442276 0.4366893661235884 1.5075062759483802 0.0 0.8715475629418188 0.3304871916560691 0.0018641172205925 1.0 0.0653907127050202 0.0112385866308786 0.0034377129995212 +Glycosyl hydrolase, all-beta [IPR013780] 5 7 1.9651085188918735 0.0494016788431057 3.628640776699029 7.919902912621359 0.108448733903935 0.2677010542317815 1.6191976609214136 0.9906808437954988 1.5895506376095985 0.2857304479214345 0.0012582535978488 1.0 1.0 0.0379575415698398 0.0027630263410089 diff --git a/interpro_homologous_superfamily/metrics.json b/interpro_homologous_superfamily/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..9a15431dda5dad1a10c471b443b7483115461b16 --- /dev/null +++ b/interpro_homologous_superfamily/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3120, + "annotations_size": 953, + "title": "Average number of proteins per term", + "value": 4.826862539349423 +} \ No newline at end of file diff --git a/interpro_homologous_superfamily/paths.json b/interpro_homologous_superfamily/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..22f1a1533067b490e170f6c1dd08a258c829077f --- /dev/null +++ b/interpro_homologous_superfamily/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_homologous_superfamily/fragment/C390/C390_val_log2fc"} \ No newline at end of file diff --git a/interpro_homologous_superfamily/result.tsv b/interpro_homologous_superfamily/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..2ec279a46896018e15f83949d0d9453f40d9461b --- /dev/null +++ b/interpro_homologous_superfamily/result.tsv @@ -0,0 +1,126 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Mitochondrial carrier domain superfamily [IPR023395] 0.7329135042392056 3.202275118127538 0.0013634671142808 0.727541998508189 0.3068606651764416 19 P12236,Q9H936,O43772,Q6NUK1,P12235,Q9Y6C9,Q70HW3,O75746,Q9BQT8,Q9H2D1,Q9HC21,Q9UBX3,Q9UJS0,O43808,P05141,Q9NZJ7 16 +Alpha/Beta hydrolase fold [IPR029058] 0.6680814364055043 3.1095185917385244 0.0018739249076147 0.8326262268760378 0.3068606651764416 25 Q9UMR5,Q9NUJ1,Q9H3G5,P38571,Q9H6V9,P50897,P42785,P07099,Q9HB40,Q8NCC3,P10619 11 +Glycoside hydrolase superfamily [IPR017853] 0.7257396051445099 2.7874388101801935 0.0053126486296897 0.9937579761582022 0.3068606651764416 15 P06280,P08236,Q9BTY2,P04066,P04062,P16278,P54802,P06865 8 +P-type ATPase, A domain superfamily [IPR008250] 0.8631105398457536 2.7360476652840746 0.0062182018272194 0.997379650156626 0.3068606651764416 8 P16615,P98194,P20020,P05023,Q04656,Q9HD20,P35670 7 +P-type ATPase, cytoplasmic domain N [IPR023299] 0.8631105398457536 2.7360476652840746 0.0062182018272194 0.997379650156626 0.3068606651764416 8 P16615,P98194,P20020,P05023,Q04656,Q9HD20,P35670 7 +P-type ATPase, transmembrane domain superfamily [IPR023298] 0.8631105398457536 2.7360476652840746 0.0062182018272194 0.997379650156626 0.3068606651764416 8 P16615,P98194,P20020,P05023,Q04656,Q9HD20,P35670 7 +HAD-like superfamily [IPR036412] 0.604002559197749 2.5075294971845397 0.0121578433613458 0.9999913455232172 0.3068606651764416 21 P16615,P98194,P20020,P05023,Q04656,P23634,Q9HD20,Q3ZCQ8,P35670,Q969T7 10 +HAD superfamily [IPR023214] 0.604002559197749 2.5075294971845397 0.0121578433613458 0.9999913455232172 0.3068606651764416 21 P16615,P98194,P20020,P05023,Q04656,P23634,Q9HD20,Q3ZCQ8,P35670,Q969T7 10 +Histidine phosphatase superfamily [IPR029033] 0.8286196732568796 2.260587556270465 0.023784809026955 0.999999999891127 0.3084808573764702 6 Q9NPH0 1 +Tubulin/FtsZ, GTPase domain superfamily [IPR036525] 0.7579265360023 2.239458624262987 0.0251260905899621 0.9999999999706324 0.3090532103244804 8 Q13885,Q9BVA1,P07437,Q9BUF5,P68371 5 +Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400] 0.931757166268923 2.234204434927569 0.0254696247701968 0.9999999999790108 0.3090532103244804 4 O43169,Q9UMX5 2 +LEM/LEM-like domain superfamily [IPR011015] 0.8061358253085664 2.1599450062333303 0.030776927092343 0.9999999999998846 0.3090532103244804 6 P50402,Q86XL3,Q9Y2U8,P42167 4 +Porin domain superfamily [IPR023614] 0.9058151096950652 2.128696365717083 0.0332793897230625 0.9999999999999902 0.3090532103244804 4 P21796,Q9Y277 2 +Immunoglobulin-like domain superfamily [IPR036179] 0.6440187365292319 2.116601952687457 0.0342936442633112 0.9999999999999964 0.3090532103244804 13 P10321,P04439,Q08722,P35613,O75962,Q5ZPR3,P78310,P10586 8 +FAD/NAD(P)-binding domain superfamily [IPR036188] 0.5762958961020178 2.103290841670821 0.0354403535297656 0.9999999999999988 0.3090532103244804 18 P09622,Q14534,Q16134,O95831,Q9H9P8,Q96CU9,Q9UHG3,Q8NB78,Q6NUM9 9 +Tubulin/FtsZ-like, C-terminal domain [IPR037103] 0.7644139892546106 2.0895229346523223 0.0366606756361753 0.9999999999999996 0.3090532103244804 7 Q13885,Q9BVA1,P07437,Q9BUF5,P68371 5 +Tubulin/FtsZ, C-terminal [IPR008280] 0.7644139892546106 2.0895229346523223 0.0366606756361753 0.9999999999999996 0.3090532103244804 7 Q13885,Q9BVA1,P07437,Q9BUF5,P68371 5 +Tubulin, C-terminal [IPR023123] 0.7644139892546106 2.0895229346523223 0.0366606756361753 0.9999999999999996 0.3090532103244804 7 Q13885,Q9BVA1,P07437,Q9BUF5,P68371 5 +EF-hand domain pair [IPR011992] 0.4610686410568 2.0873015621603255 0.0368608836714499 0.9999999999999996 0.3090532103244804 48 Q6NUK1,Q9UBV8,Q9NWM8,O95202,Q8NF37,P80303,Q15293,Q02818,O75746,Q9H4M9,P41208,Q96D71,Q9UJS0,Q9BRK5,Q9H223,O43852,Q14257,Q9BPX6,Q8IYU8 19 +Band 7/SPFH domain superfamily [IPR036013] 0.7401220687439651 1.9746404883921191 0.0483089608858686 1.0 0.324688275430895 7 O75477,P35232,O94905,Q99623,Q9UJZ1,O75955 6 +Metalloenzyme, LuxS/M16 peptidase-like [IPR011249] 0.7385927749789158 1.9673585519977208 0.0491418891833179 1.0 0.324688275430895 7 Q10713,P22695 2 +Glycosyl hydrolase, all-beta [IPR013780] 0.7381204888158128 1.9651085188918735 0.0494016788431057 1.0 0.324688275430895 7 P06280,Q9BTY2,P10253,P04066,Q16706 5 +GOLD domain superfamily [IPR036598] 0.8517330894050188 1.9052075217139568 0.0567531008522257 1.0 0.3350132724629841 4 Q15363,Q9Y3B3 2 +SNARE [IPR010989] 0.7188987199297667 1.8730640076501348 0.0610595467608077 1.0 0.3505406509822274 7 O15400,O60499,O43752,Q12846,Q13190 5 +NAP-like superfamily [IPR037231] 0.8333649540570884 1.8282713808478468 0.0675088327698043 1.0 0.3673700413748202 4 Q01105,Q99733 2 +Tetraspanin, EC2 domain superfamily [IPR008952] 0.985246953175112 1.7369545789164331 0.0823951884768312 1.0 0.4011557994468111 2 O60637 1 +MFS transporter superfamily [IPR036259] 0.6296770064760743 1.6791786781264246 0.0931172261193609 1.0 0.420572116074649 9 P41440,Q16625,Q9NY64 3 +Cytochrome P450 superfamily [IPR036396] 0.9650416933932058 1.6533195227553723 0.0982658517841232 1.0 0.427613501142783 2 Q6UW02 1 +Haem oxygenase-like, multi-helical [IPR016084] 0.9637588197562574 1.6480032080369134 0.0993520128786429 1.0 0.4284274582504376 2 P30519 1 +SH3-like domain superfamily [IPR036028] 0.4332897340349427 1.6198547070750249 0.1052634912674095 1.0 0.4348881948834287 35 Q96RU3,Q5JRA6,Q92783,Q9NZW5,Q96PC5,Q00013,O00459,Q9Y371,P20936,Q14847,Q9UQB8,O75962,P46108,Q14168,Q14185 15 +Isoprenoid synthase domain superfamily [IPR008949] 0.7828199241298437 1.6141605105563086 0.1064926150294047 1.0 0.4348881948834287 4 O95749 1 +Choline/Carnitine o-acyltransferase, domain 2 [IPR042231] 0.949326491340603 1.5881568732825069 0.112250870429079 1.0 0.4457294979954679 2 P23786 1 +Zinc finger, RanBP2-type superfamily [IPR036443] 0.6107233165504758 1.493476447104051 0.1353125150405922 1.0 0.4665527646836281 8 Q92804,P98175,P35637,P52756 4 +AH/BAR domain superfamily [IPR027267] 0.515609923004998 1.4892852642870706 0.136412266385679 1.0 0.4665527646836281 15 O60749,Q96RU3,Q9Y5X3,Q9Y371,P53367,Q9UQB8 6 +Bcl-2-like superfamily [IPR036834] 0.9246311738293778 1.4856618615889672 0.1373685832877489 1.0 0.4665527646836281 2 Q07820 1 +Alkaline-phosphatase-like, core domain superfamily [IPR017850] 0.9214239897370108 1.4723497642086485 0.1409264513878836 1.0 0.4703944475034508 2 Q5H8A4 1 +GMP phosphodiesterase, delta subunit superfamily [IPR037036] 0.921103271327782 1.471018608994737 0.141286084359103 1.0 0.4703944475034508 2 O43924 1 +ABC transporter type 1, transmembrane domain superfamily [IPR036640] 0.9054809490010516 1.4667231401015344 0.1424513853740832 1.0 0.4703944475034508 3 O75027 1 +Immunoglobulin-like fold [IPR013783] 0.415506115370351 1.4345837619557091 0.1514057445271035 1.0 0.4809655817810989 32 Q15375,P04439,P10321,P08236,Q08722,Q8IZA0,P35613,O15031,O75962,Q14118,Q5ZPR3,P78310,Q8NHP6,P10586 14 +Peptidase M4/M1, CTD superfamily [IPR027268] 0.6702116377227508 1.4079887549565422 0.1591343997921734 1.0 0.4892099451675527 5 P55786,Q9UIQ6,Q9NZ08 3 +Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097] 0.6702116377227508 1.4079887549565422 0.1591343997921734 1.0 0.4892099451675527 5 P55786,Q9UIQ6,Q9NZ08 3 +Rhomboid-like superfamily [IPR035952] 0.8813341885824242 1.3062003258496329 0.1914844420495374 1.0 0.519899354054727 2 Q9H300 1 +Prefoldin [IPR009053] 0.6419778947232611 1.276807930595658 0.2016700649847322 1.0 0.5344633163844588 5 O15212,Q9UHV9 2 +FAD-binding, type PCMH-like superfamily [IPR036318] 0.871391917896088 1.2651385806618702 0.2058216548930707 1.0 0.5344633163844588 2 O00116 1 +FAD-binding, type PCMH, subdomain 2 [IPR016169] 0.871391917896088 1.2651385806618702 0.2058216548930707 1.0 0.5344633163844588 2 O00116 1 +START-like domain superfamily [IPR023393] 0.8410180460853771 1.2146244532515842 0.2245093579828521 1.0 0.5610597860247006 3 O95433 1 +MAN1, winged-helix domain [IPR041885] 0.8588838999358559 1.213614680325004 0.2248948984904886 1.0 0.5610597860247006 2 Q9Y2U8 1 +Lamin tail domain superfamily [IPR036415] 0.8193776066730817 1.1303912421760849 0.2583114027736037 1.0 0.6057306622393075 3 P20700,Q03252 2 +Regulatory factor, effector binding domain superfamily [IPR011256] 0.8383579217447266 1.1294907974426178 0.2586908494558217 1.0 0.6057306622393075 2 Q9Y6I9 1 +RmlC-like jelly roll fold [IPR014710] 0.5286398077518861 1.1267733252781007 0.2598383313154628 1.0 0.606926298391265 9 Q8IY17,Q6P4Q7,P38435,Q9BV57 4 +DHS-like NAD/FAD-binding domain superfamily [IPR029035] 0.5833189671738152 1.107042579012683 0.2682755196548023 1.0 0.6168551547959001 6 A1L0T0,Q13423 2 +Fibronectin type II domain superfamily [IPR036943] 0.8127088634088742 1.104522994598588 0.269366334404014 1.0 0.6168551547959001 3 Q9UBV2 1 +Kringle-like fold [IPR013806] 0.8127088634088742 1.104522994598588 0.269366334404014 1.0 0.6168551547959001 3 Q9UBV2 1 +Ricin B-like lectins [IPR035992] 0.8087798324602065 1.0893062969503309 0.2760188368547847 1.0 0.6248122363957478 3 Q10472 1 +Beta-hexosaminidase-like, domain 2 [IPR029018] 0.80558229066409 1.076936892308486 0.2815084600194968 1.0 0.6342259158358876 3 P06865,P54802 2 +C-type lectin fold [IPR016187] 0.788473881715264 1.011004332506981 0.3120143561794011 1.0 0.655790094532204 3 Q9UBG0 1 +L27 domain superfamily [IPR036892] 0.6412066752246299 1.004520115224254 0.3151279805453857 1.0 0.6560294987954065 4 Q14168,O14936,Q9NZW5 3 +Sterile alpha motif/pointed domain superfamily [IPR013761] 0.5134034205203475 0.9750336201849444 0.3295435833631699 1.0 0.6577984334464635 8 Q15375,Q9NZI7 2 +Chaperone J-domain superfamily [IPR036869] 0.4131624499448728 0.942233513789178 0.3460730991046543 1.0 0.6742831484819385 18 Q13217,Q9Y2G8,Q9UGP8,Q96KC8 4 +Peptidase M41-like [IPR037219] 0.7873636946760736 0.9240918947173076 0.3554384729456581 1.0 0.682666499808615 2 Q9Y4W6 1 +MHC class I-like antigen recognition-like superfamily [IPR037055] 0.7641963426371582 0.9183484135225084 0.3584364887148501 1.0 0.682666499808615 3 P10321,P04439 2 +MHC classes I/II-like antigen recognition protein [IPR011162] 0.7641963426371582 0.9183484135225084 0.3584364887148501 1.0 0.682666499808615 3 P10321,P04439 2 +Heavy metal-associated domain superfamily [IPR036163] 0.7639711021456532 0.9174947590733288 0.3588834379896286 1.0 0.682666499808615 3 P35670 1 +Mannose-6-phosphate receptor binding domain superfamily [IPR009011] 0.7579285276276021 0.8946401479983707 0.3709794828717094 1.0 0.6918658457470432 3 P20645 1 +Peptidase S1, PA clan [IPR009003] 0.7745349583066332 0.8735705593569408 0.3823521649902788 1.0 0.7102955423698551 2 Q7KZN9 1 +Membrane associated eicosanoid/glutathione metabolism-like domain superfamily [IPR023352] 0.7677998717126349 0.8472856434255989 0.3968359268355486 1.0 0.7203516919510053 2 Q99735 1 +Zinc finger, CCHC-type superfamily [IPR036875] 0.7422274812094225 0.8357127487264787 0.4033165214652878 1.0 0.7264186952575216 3 Q9NUD5 1 +Cyclic nucleotide-binding-like [IPR018490] 0.5460981675643182 0.8317341573423771 0.4055590160077054 1.0 0.7264186952575216 5 Q6P4Q7 1 +Sodium/potassium-transporting ATPase subunit beta superfamily [IPR038702] 0.7584990378447709 0.8112855707981952 0.4172016943837082 1.0 0.7264186952575216 2 P05026 1 +LAP1C-like, C-terminal domain superfamily [IPR038599] 0.7395766516998055 0.7392405865800653 0.4597609195723933 1.0 0.7589656079190595 2 Q5JTV8 1 +Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily [IPR036784] 0.710619185113891 0.7195343396595459 0.4718117518621465 1.0 0.7660763101037612 3 Q15118,Q15120 2 +Proteasome activator PA28, C-terminal domain superfamily [IPR036997] 0.7086942572986783 0.7125840507061497 0.4761031840298393 1.0 0.7660763101037612 3 P61289,Q9UL46 2 +Proteasome activator superfamily [IPR036252] 0.7086942572986783 0.7125840507061497 0.4761031840298393 1.0 0.7660763101037612 3 P61289,Q9UL46 2 +Proteasome activator PA28, N-terminal domain superfamily [IPR036996] 0.7086942572986783 0.7125840507061497 0.4761031840298393 1.0 0.7660763101037612 3 P61289,Q9UL46 2 +ARFGAP/RecO-like zinc finger [IPR037278] 0.7322001282873615 0.7116402634821991 0.4766875675671882 1.0 0.7660763101037612 2 Q8N6T3 1 +ArfGAP domain superfamily [IPR038508] 0.7322001282873615 0.7116402634821991 0.4766875675671882 1.0 0.7660763101037612 2 Q8N6T3 1 +Class II aldolase/adducin N-terminal domain superfamily [IPR036409] 0.7270686337395744 0.692615948797198 0.4885505987827829 1.0 0.7696145901006016 2 P35611 1 +Galactose-binding-like domain superfamily [IPR008979] 0.4371152312121502 0.6792562483275776 0.4969755129804125 1.0 0.7761330208124241 10 Q15375,P16278,P08236 3 +SCP2 sterol-binding domain superfamily [IPR036527] 0.6965030478023723 0.6689500410373761 0.5035273473780708 1.0 0.7789960422910738 3 P22307,Q6YN16 2 +PDZ superfamily [IPR036034] 0.3597381653718837 0.6613804180035119 0.5083683806978465 1.0 0.7852108051945668 21 O43464,Q00013,O00560,P57105,Q14168 5 +FAD/NAD-linked reductase, dimerisation domain superfamily [IPR016156] 0.5562167060715338 0.649653069696384 0.515916344674284 1.0 0.7904634670009528 4 O95831 1 +Chloramphenicol acetyltransferase-like domain superfamily [IPR023213] 0.4746357120343629 0.5862977221375771 0.557675461502857 1.0 0.8201615969324424 6 P23786 1 +PapD-like superfamily [IPR008962] 0.6718860167738868 0.5831165040858051 0.5598148741435278 1.0 0.8207941658552322 3 Q8NHP6 1 +Aldehyde/histidinol dehydrogenase [IPR016161] 0.4222879963146634 0.5430789796987616 0.5870754247657917 1.0 0.840926016592293 9 P51648 1 +Aldehyde dehydrogenase, C-terminal [IPR016163] 0.4222879963146634 0.5430789796987616 0.5870754247657917 1.0 0.840926016592293 9 P51648 1 +Aldehyde dehydrogenase, N-terminal [IPR016162] 0.4222879963146634 0.5430789796987616 0.5870754247657917 1.0 0.840926016592293 9 P51648 1 +RmlC-like cupin domain superfamily [IPR011051] 0.5208053958814791 0.5113965572128115 0.6090734051626749 1.0 0.8412274711884482 4 Q9BV57,P38435 2 +EB1, C-terminal domain superfamily [IPR036133] 0.6703014753046788 0.4938208777722779 0.6214326872003304 1.0 0.8526666446415683 2 Q15555 1 +14-3-3 domain superfamily [IPR036815] 0.4457289659601848 0.4561499034339971 0.6482821868260846 1.0 0.8687557682213138 6 P62258,Q04917,P31946,P61981,P63104 5 +PX domain superfamily [IPR036871] 0.4011637694958569 0.4331957652450436 0.6648725551137589 1.0 0.8721890664485193 9 O60749 1 +Galactose mutarotase-like domain superfamily [IPR011013] 0.6223063191491638 0.4219383864873471 0.6730699903835116 1.0 0.8721890664485193 3 P10253 1 +Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid [IPR008930] 0.6398332264272069 0.3981248917189904 0.69053812681825 1.0 0.8721890664485193 2 P48449 1 +Nucleophile aminohydrolases, N-terminal [IPR029055] 0.3333914700238272 0.366641549179252 0.7138864115086445 1.0 0.8721890664485193 18 P28074 1 +Acyl-CoA binding protein superfamily [IPR035984] 0.6289288005131448 0.3661449829219831 0.7142568930227418 1.0 0.8721890664485193 2 Q9H3P7 1 +G protein alpha subunit, helical insertion [IPR011025] 0.3996789727126849 0.2281850754300285 0.8195023634863821 1.0 0.925535900262066 5 P04899,Q14344,P09471,P63096 4 +Ferredoxin-NADP reductase (FNR), nucleotide-binding domain [IPR039261] 0.533081492039295 0.1879291209057812 0.8509322142538598 1.0 0.9434879762257138 3 P16435 1 +Riboflavin synthase-like beta-barrel [IPR017938] 0.533081492039295 0.1879291209057812 0.8509322142538598 1.0 0.9434879762257138 3 P16435 1 +H/ACA RNP complex subunit Gar1/Naf1, Cbf5-binding domain [IPR038664] 0.5493906350224439 0.1758061711288388 0.8604462212937736 1.0 0.9470103462740728 2 Q96HR8 1 +Beta-grasp domain superfamily [IPR012675] 0.3484510999803863 0.159509556529837 0.8732674296923595 1.0 0.9522012133830876 8 P21912 1 +HSP90, C-terminal domain [IPR037196] 0.4082156611039822 0.1525943600492813 0.8787181729390967 1.0 0.9537795202858304 4 P07900,P14625,Q12931 3 +NO signalling/Golgi transport ligand-binding domain superfamily [IPR024096] 0.5314304041051887 0.1442180463396917 0.8853282909955575 1.0 0.9587702969531436 2 Q8IUR0 1 +Pyridoxal phosphate-dependent transferase, small domain [IPR015422] 0.3131104080226189 0.13416114770144 0.8932751477486627 1.0 0.9624896473563466 14 O95470 1 +Cobalamin-binding domain superfamily [IPR036724] 0.5246953175112181 0.1334815854040452 0.8938125266635537 1.0 0.9624896473563466 2 Q99707 1 +Ankyrin repeat-containing domain superfamily [IPR036770] 0.3117491019175985 0.1270786112325938 0.8988781799645451 1.0 0.9657911400276452 14 Q8IZ07 1 +Cyclic phosphodiesterase [IPR009097] 0.5157152020525906 0.1200955955637419 0.9044074213710293 1.0 0.969516617060282 2 Q8N9N2 1 +Arrestin-like, C-terminal [IPR014752] 0.5070558050032016 0.1081782476017425 0.9138542995818412 1.0 0.9763488200689404 2 Q4G0F5 1 +Dbl homology (DH) domain superfamily [IPR035899] 0.3860718870346706 0.1025868307551662 0.9182908952252076 1.0 0.9788939856259764 4 Q14155,O94887,O75962 3 +Pyridoxal phosphate-dependent transferase [IPR015424] 0.3001111087857676 0.0917199481760163 0.9269205478448644 1.0 0.9836918508865876 15 O95470 1 +Pyridoxal phosphate-dependent transferase, major domain [IPR015421] 0.3001111087857676 0.0917199481760163 0.9269205478448644 1.0 0.9836918508865876 15 O95470 1 +CRIB domain superfamily [IPR036936] 0.4900577293136547 0.0875278612610543 0.9302519403263344 1.0 0.9850334434788852 2 O96013 1 +GAR domain superfamily [IPR036534] 0.4711353431686956 0.0685860908863894 0.9453190906584334 1.0 0.9910771104482806 2 Q9UPN3 1 +ANL, N-terminal domain [IPR042099] 0.3428571428571468 0.0650037313980638 0.9481710293144564 1.0 0.9918847320929496 5 O95573,Q6P1M0,P33121,O60488 4 +Neurolysin/Thimet oligopeptidase, domain 2 [IPR024077] 0.4581328200192496 0.0635966393329192 0.9492914077509058 1.0 0.9919678855116372 3 Q9BYT8,Q99797 2 +PD-(D/E)XK endonuclease-like domain superfamily [IPR011604] 0.4611930724823534 0.0602202361801133 0.9519802288212712 1.0 0.9926008293946078 2 P51530 1 +Neurolysin/Thimet oligopeptidase, N-terminal [IPR024080] 0.457985888389989 0.0577404057359916 0.9539554082444754 1.0 0.9935732284775792 2 Q9BYT8 1 +FF domain superfamily [IPR036517] 0.4361770365618917 0.0434853759487206 0.9653146218015536 1.0 0.995680224460383 2 O75400 1 +AP-2 complex subunit mu, C-terminal superfamily [IPR036168] 0.3533376123234999 0.0433424088190161 0.9654285856187624 1.0 0.995680224460383 4 Q9BXS5,P48444,Q9Y2T2 3 +Gamma-tubulin complex component, C-terminal domain superfamily [IPR042241] 0.412764592687614 0.0326059623547174 0.9739888150886178 1.0 0.9991510665010256 2 Q9BSJ2 1 +Fibronectin type III superfamily [IPR036116] 0.3239213506839039 0.0240457286708706 0.9808161330340064 1.0 1.0 5 Q15375 1 +VPS9 domain superfamily [IPR037191] 0.3835792174470755 0.0240137346349209 0.9808416532122308 1.0 1.0 2 Q14C86 1 +Zinc finger, ZZ-type superfamily [IPR043145] 0.3869104908565923 0.0052595700925606 0.9958034895747598 1.0 1.0 3 P46939,Q13501 2 +ARID DNA-binding domain superfamily [IPR036431] 0.3811357074109737 0.0025518882016442 0.9979638900129166 1.0 1.0 3 P29375,Q4LE39 2 +Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410] 0.3808148861084363 0.002408651190108 0.9980781762613292 1.0 1.0 3 Q96EY1,O60884 2 +MIT domain superfamily [IPR036181] 0.3763233878729565 0.000480048216981 0.9996169769539408 1.0 1.0 3 O75351,Q8N0X7 2 +Longin-like domain superfamily [IPR011012] 0.2936635574139538 0.000479949649551 0.9996170555993624 1.0 1.0 11 P51809,Q96CW1,O15498,P53680,Q9BXS5,P08240,Q9Y2T2,O75396,P61923,P48444 10 diff --git a/interpro_homologous_superfamily/selections.json b/interpro_homologous_superfamily/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..e14ec3a1b5e1d1be5b5fee7582377488ea554e62 --- /dev/null +++ b/interpro_homologous_superfamily/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 domain superfamily [IPR036815]", "2Fe-2S ferredoxin-like superfamily [IPR036010]", "30s ribosomal protein S13, C-terminal [IPR027437]", "4'-phosphopantetheinyl transferase domain superfamily [IPR037143]", "5'-3' exonuclease, C-terminal domain superfamily [IPR036279]", "5-formyltetrahydrofolate cyclo-ligase-like domain superfamily [IPR024185]", "50S ribosomal protein L10, insertion domain superfamily [IPR043164]", "50S ribosomal protein L30e-like [IPR029064]", "6-phosphogluconate dehydrogenase, domain 2 [IPR013328]", "6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily [IPR008927]", "AAR2, C-terminal domain superfamily [IPR038514]", "AAR2, N-terminal domain superfamily [IPR038516]", "ABC transporter type 1, transmembrane domain superfamily [IPR036640]", "ACP-like superfamily [IPR036736]", "ADF-H/Gelsolin-like domain superfamily [IPR029006]", "ADP-ribosylation/Crystallin J1 superfamily [IPR036705]", "AF1104-like superfamily [IPR036075]", "AH/BAR domain superfamily [IPR027267]", "AICAR transformylase, duplicated domain superfamily [IPR024051]", "AICAR transformylase, insert domain superfamily [IPR024050]", "AMP-binding enzyme, C-terminal domain superfamily [IPR045851]", "ANL, N-terminal domain [IPR042099]", "ANTH domain superfamily [IPR014712]", "AP-2 complex subunit mu, C-terminal superfamily [IPR036168]", "APC, N-terminal coiled-coil domain superfamily [IPR036149]", "ARFGAP/RecO-like zinc finger [IPR037278]", "ARID DNA-binding domain superfamily [IPR036431]", "ATP synthase subunit alpha, N-terminal domain-like superfamily [IPR023366]", "ATP synthase, F0 complex, subunit A superfamily [IPR035908]", "ATP synthase, F0 complex, subunit D superfamily, mitochondrial [IPR036228]", "ATP synthase, F1 complex, gamma subunit superfamily [IPR035968]", "ATP synthase, alpha subunit, C-terminal domain superfamily [IPR038376]", "ATP-NAD kinase, PpnK-type, C-terminal [IPR017437]", "ATP-grasp fold, subdomain 1 [IPR013815]", "ATP:guanido phosphotransferase, N-terminal domain superfamily [IPR036802]", "ATPase, F1/V1 complex, beta/alpha subunit, C-terminal [IPR024034]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily [IPR036121]", "ATPase, V1 complex, subunit H, C-terminal domain superfamily [IPR038497]", "ATPase, nucleotide binding domain [IPR043129]", "Acetylglutamate kinase-like superfamily [IPR036393]", "Aconitase, domain 2 [IPR015932]", "Aconitase, iron-sulfur domain [IPR036008]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 [IPR015931]", "Aconitase/3-isopropylmalate dehydratase, swivel [IPR015928]", "Actin-crosslinking [IPR008999]", "Actin-related protein 2/3 complex subunit 3 superfamily [IPR036753]", "Actin-related protein 2/3 complex subunit 5 superfamily [IPR036743]", "Activator of Hsp90 ATPase, Aha1 [IPR036338]", "Acyl transferase domain superfamily [IPR001227]", "Acyl transferase/acyl hydrolase/lysophospholipase [IPR016035]", "Acyl-CoA N-acyltransferase [IPR016181]", "Acyl-CoA binding protein superfamily [IPR035984]", "Acyl-CoA dehydrogenase-like, C-terminal [IPR036250]", "Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily [IPR009100]", "Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily [IPR037069]", "Adenine nucleotide alpha hydrolase-like domains [IPR023382]", "Adenomatous polyposis coli protein [IPR026831]", "Adenosylhomocysteinase-like superfamily [IPR042172]", "Adenylate cyclase-associated CAP, C-terminal superfamily [IPR036223]", "Adenylate cyclase-associated CAP, N-terminal domain superfamily [IPR036222]", "Adenylate kinase, active site lid domain superfamily [IPR036193]", "Adenylosuccinate synthetase, domain 1 [IPR042109]", "Adenylosuccinate synthetase, domain 2 [IPR042110]", "Adenylosuccinate synthetase, domain 3 [IPR042111]", "Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily [IPR018162]", "Aldehyde dehydrogenase, C-terminal [IPR016163]", "Aldehyde dehydrogenase, N-terminal [IPR016162]", "Aldehyde/histidinol dehydrogenase [IPR016161]", "Aldolase-type TIM barrel [IPR013785]", "Alkaline-phosphatase-like, core domain superfamily [IPR017850]", "Allosteric substrate binding domain superfamily [IPR029009]", "Alpha-D-phosphohexomutase, C-terminal domain superfamily [IPR036900]", "Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III [IPR016055]", "Alpha-catenin/vinculin-like superfamily [IPR036723]", "Alpha-dystroglycan domain 2 [IPR027468]", "Alpha-glycerophosphate oxidase, C-terminal domain superfamily [IPR038299]", "Alpha-helical ferredoxin [IPR009051]", "Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily [IPR036784]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily [IPR037151]", "Alpha/Beta hydrolase fold [IPR029058]", "Alpha/beta knot methyltransferases [IPR029028]", "Amidase signature (AS) superfamily [IPR036928]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 [IPR020751]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding superfamily [IPR008925]", "Aminoacyl-tRNA synthetase, class Ia, anticodon-binding [IPR009080]", "Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097]", "Ankyrin repeat-containing domain superfamily [IPR036770]", "Annexin superfamily [IPR037104]", "Anticodon-binding domain superfamily [IPR036621]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain superfamily [IPR036732]", "ApaG domain superfamily [IPR036767]", "ArfGAP domain superfamily [IPR038508]", "Arginyl tRNA synthetase N-terminal domain superfamily [IPR036695]", "Armadillo-like helical [IPR011989]", "Armadillo-type fold [IPR016024]", "Arp2/3 complex subunit 2/4 [IPR034666]", "Arrestin-like, C-terminal [IPR014752]", "Aspartate decarboxylase-like domain superfamily [IPR009010]", "Aspartate/ornithine carbamoyltransferase superfamily [IPR036901]", "Aspartic peptidase domain superfamily [IPR021109]", "Aspartyl/glutamyl-tRNA amidotransferase subunit B-like [IPR003789]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C-terminal, domain 2 [IPR023168]", "At2g17340, three-helix bundle domain [IPR035073]", "B30.2/SPRY domain superfamily [IPR043136]", "BAG domain superfamily [IPR036533]", "BEACH domain superfamily [IPR036372]", "BRCT domain superfamily [IPR036420]", "BRK domain superfamily [IPR037259]", "BRO1 domain superfamily [IPR038499]", "BSD domain superfamily [IPR035925]", "Bacterial exopeptidase dimerisation domain [IPR036264]", "Band 7/SPFH domain superfamily [IPR036013]", "Barrier-to-autointegration factor, BAF superfamily [IPR036617]", "Bcl-2-like superfamily [IPR036834]", "Beta-Galactosidase/glucuronidase domain superfamily [IPR036156]", "Beta-catenin-interacting ICAT superfamily [IPR036911]", "Beta-grasp domain superfamily [IPR012675]", "Beta-hexosaminidase-like, domain 2 [IPR029018]", "Beta-lactamase/transpeptidase-like [IPR012338]", "Beta-trefoil domain superfamily [IPR036358]", "BolA-like superfamily [IPR036065]", "Bromo adjacent homology (BAH) domain superfamily [IPR043151]", "Bromodomain-like superfamily [IPR036427]", "C-type lectin fold [IPR016187]", "C-type lectin-like/link domain superfamily [IPR016186]", "C2 domain superfamily [IPR035892]", "CAP Gly-rich domain superfamily [IPR036859]", "CCR4-NOT complex subunit 2/3/5, N-terminal domain superfamily [IPR038635]", "CCR4-NOT subunit 1, TTP binding domain superfamily [IPR038535]", "CDC48 domain 2-like superfamily [IPR029067]", "CDP-alcohol phosphatidyltransferase, transmembrane domain [IPR043130]", "CH domain superfamily [IPR036872]", "CKK domain superfamily [IPR038209]", "CPI-17 superfamily [IPR036658]", "CRAL-TRIO lipid binding domain superfamily [IPR036865]", "CRAL/TRIO, N-terminal domain superfamily [IPR036273]", "CRIB domain superfamily [IPR036936]", "CSTF1, dimerization domain superfamily [IPR038184]", "CYTH-like domain superfamily [IPR033469]", "Cadherin-like superfamily [IPR015919]", "Calcyclin-binding protein, N-terminal [IPR037201]", "Calpain large subunit, domain III superfamily [IPR036213]", "Calreticulin/calnexin, P domain superfamily [IPR009033]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily [IPR036480]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily [IPR036897]", "Carbohydrate-binding-like fold [IPR013784]", "Carboxypeptidase-like, regulatory domain superfamily [IPR008969]", "Carnitine o-acyltransferase, N-terminal [IPR042572]", "Casein kinase II subunit beta-like [IPR035991]", "Casein kinase II, regulatory subunit, N-terminal [IPR016149]", "Catenin binding domain superfamily [IPR027397]", "Cathepsin C, exclusion domain superfamily [IPR036496]", "Cation efflux transmembrane domain superfamily [IPR027469]", "Cdc37, Hsp90-binding domain superfamily [IPR038189]", "Cell division control protein 73, C-terminal domain superfamily [IPR038103]", "Chaperone J-domain superfamily [IPR036869]", "Chitinase insertion domain superfamily [IPR029070]", "Chloramphenicol acetyltransferase-like domain superfamily [IPR023213]", "Chloride channel, core [IPR014743]", "Choline/Carnitine o-acyltransferase, domain 2 [IPR042231]", "Chromo-like domain superfamily [IPR016197]", "Citrate synthase superfamily [IPR036969]", "Citrate synthase-like, large alpha subdomain [IPR016142]", "Citrate synthase-like, small alpha subdomain [IPR016143]", "Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm [IPR010978]", "Class I glutamine amidotransferase-like [IPR029062]", "Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) [IPR045864]", "Class II aldolase/adducin N-terminal domain superfamily [IPR036409]", "Clathrin adaptor, appendage, Ig-like subdomain superfamily [IPR013041]", "Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain [IPR013037]", "Clathrin heavy chain, N-terminal [IPR016025]", "ClpP/crotonase-like domain superfamily [IPR029045]", "Coatomer, gamma subunit, appendage domain superfamily [IPR037067]", "Coatomer/calthrin adaptor appendage, C-terminal subdomain [IPR009028]", "Cobalamin (vitamin B12)-dependent enzyme, catalytic [IPR016176]", "Cobalamin adenosyltransferase-like superfamily [IPR036451]", "Cobalamin-binding domain superfamily [IPR036724]", "Concanavalin A-like lectin/glucanase domain superfamily [IPR013320]", "Core-binding factor, beta subunit superfamily [IPR036552]", "Creatinase/Aminopeptidase P/Spt16, N-terminal [IPR029149]", "Creatinase/aminopeptidase-like [IPR036005]", "Cullin homology domain superfamily [IPR036317]", "Cullin repeat-like-containing domain superfamily [IPR016159]", "Cupredoxin [IPR008972]", "Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal [IPR016098]", "Cyclic nucleotide-binding-like [IPR018490]", "Cyclic phosphodiesterase [IPR009097]", "Cyclin-like superfamily [IPR036915]", "Cyclophilin-like domain superfamily [IPR029000]", "Cytidine deaminase-like [IPR016193]", "Cytochrome C oxidase subunit II, transmembrane domain superfamily [IPR036257]", "Cytochrome P450 superfamily [IPR036396]", "Cytochrome b-c1 complex subunit 7 superfamily [IPR036544]", "Cytochrome b-c1 complex subunit 8 superfamily [IPR036642]", "Cytochrome b-c1 complex subunit 9 superfamily [IPR036656]", "Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400]", "Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily [IPR037008]", "Cytochrome c oxidase assembly protein CtaG/Cox11, domain superfamily [IPR023471]", "Cytochrome c oxidase subunit IV superfamily [IPR036639]", "Cytochrome c oxidase subunit VIIc superfamily [IPR036636]", "Cytochrome c oxidase, subunit VIIa superfamily [IPR036539]", "Cytochrome c oxidase, subunit Va/VI superfamily [IPR036545]", "Cytochrome c oxidase, subunit Vb superfamily [IPR036972]", "Cytochrome c-like domain superfamily [IPR036909]", "Cytochrome c1, transmembrane anchor, C-terminal [IPR021157]", "Cytochrome cd1-nitrite reductase-like, haem d1 domain superfamily [IPR011048]", "DCN1-like, PONY binding domain [IPR042460]", "DHS-like NAD/FAD-binding domain superfamily [IPR029035]", "DNA breaking-rejoining enzyme, catalytic core [IPR011010]", "DNA fragmentation factor 45kDa, C-terminal [IPR027296]", "DNA ligase, ATP-dependent, N-terminal domain superfamily [IPR036599]", "DNA mismatch repair protein MutS, N-terminal [IPR016151]", "DNA mismatch repair protein MutS, core domain superfamily [IPR036187]", "DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal [IPR008921]", "DNA polymerase alpha, zinc finger domain superfamily [IPR038256]", "DNA polymerase family B, thumb domain [IPR042087]", "DNA polymerase, palm domain superfamily [IPR023211]", "DNA repair protein XRCC4-like, C-terminal [IPR014751]", "DNA topoisomerase I, DNA binding, N-terminal domain 1 [IPR013034]", "DNA topoisomerase I, DNA binding, N-terminal domain 2 [IPR013030]", "DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily [IPR036202]", "DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type [IPR014711]", "DNA topoisomerase I, catalytic core, alpha/beta subdomain [IPR014727]", "DNA topoisomerase, type IIA, alpha-helical domain superfamily [IPR013757]", "DNA topoisomerase, type IIA, domain A, alpha-beta [IPR013758]", "DNA topoisomerase, type IIA, subunit B, C-terminal [IPR013759]", "DNA topoisomerase, type IIA-like domain superfamily [IPR013760]", "DNA-binding domain superfamily [IPR016177]", "DNA-directed RNA polymerase, N-terminal domain superfamily [IPR037159]", "DNA-directed RNA polymerase, insert domain superfamily [IPR036643]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily [IPR037033]", "DNA/RNA non-specific endonuclease superfamily [IPR044929]", "DNA/RNA polymerase superfamily [IPR043502]", "DNA/RNA-binding protein KIN17, WH-like domain superfamily [IPR038254]", "DUSP-like superfamily [IPR035927]", "Dbl homology (DH) domain superfamily [IPR035899]", "Death-like domain superfamily [IPR011029]", "Dedicator of cytokinesis, C-terminal, lobe A [IPR043161]", "Dedicator of cytokinesis, C-terminal, lobe C [IPR043162]", "Dedicator of cytokinesis, N-terminal, subdomain 1 [IPR042455]", "DhaL domain superfamily [IPR036117]", "Diaphanous, GTPase-binding domain superfamily [IPR044933]", "Dicer dimerisation domain superfamily [IPR038248]", "Dihydrofolate reductase-like domain superfamily [IPR024072]", "Dihydropteroate synthase-like [IPR011005]", "Dimeric alpha-beta barrel [IPR011008]", "Diphthamide synthesis DPH1/DPH2, domain 1 [IPR042263]", "Diphthamide synthesis DPH1/DPH2, domain 3 [IPR042265]", "Dynein heavy chain AAA lid domain superfamily [IPR042219]", "Dynein heavy chain, AAA1 domain, small subdomain [IPR043157]", "Dynein heavy chain, C-terminal domain, barrel region [IPR043160]", "Dynein heavy chain, domain 2, N-terminal [IPR042222]", "Dynein heavy chain, linker, subdomain 3 [IPR042228]", "Dynein light chain superfamily [IPR037177]", "E3-binding domain superfamily [IPR036625]", "EB1, C-terminal domain superfamily [IPR036133]", "EF-G domain III/V-like [IPR035647]", "EF-hand domain pair [IPR011992]", "ENTH/VHS [IPR008942]", "ERO1-like superfamily [IPR037192]", "ERV/ALR sulfhydryl oxidase domain superfamily [IPR036774]", "ESCRT assembly domain [IPR037202]", "ESCRT-II complex, Vps25 subunit, N-terminal winged helix [IPR014041]", "EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2 [IPR042044]", "Elongation factor EF1B gamma, C-terminal domain superfamily [IPR036433]", "Elongation factor Ts, dimerisation domain superfamily [IPR036402]", "Endonuclease/exonuclease/phosphatase superfamily [IPR036691]", "Endoplasmic reticulum resident protein 29, C-terminal domain superfamily [IPR036356]", "Enhancer of mRNA-decapping protein 4, conserved C-terminal domain [IPR044938]", "Enhancer of rudimentary superfamily [IPR035912]", "Enolase-like, C-terminal domain superfamily [IPR036849]", "Enolase-like, N-terminal [IPR029017]", "Enoyl-CoA hydratase, C-terminal [IPR014748]", "Eukaryotic translation initiation factor 3-like domain superfamily [IPR023194]", "Exocyst complex component EXOC6/Sec15, C-terminal, domain 1 [IPR042045]", "Exoribonuclease, PH domain 2 superfamily [IPR036345]", "F-actin capping protein, alpha subunit, domain 1 [IPR042489]", "F-actin-capping protein subunit alpha/beta [IPR037282]", "F-actin-capping protein subunit alpha/beta, domain 2 [IPR042276]", "F-actin-capping protein subunit beta, N-terminal domain [IPR043175]", "F-box-like domain superfamily [IPR036047]", "F1F0 ATP synthase OSCP/delta subunit, N-terminal domain superfamily [IPR026015]", "FAD-binding, type PCMH, subdomain 1 [IPR016167]", "FAD-binding, type PCMH, subdomain 2 [IPR016169]", "FAD-binding, type PCMH-like superfamily [IPR036318]", "FAD-linked oxidase-like, C-terminal [IPR016164]", "FAD/NAD(P)-binding domain superfamily [IPR036188]", "FAD/NAD-linked reductase, dimerisation domain superfamily [IPR016156]", "FCS-type zinc finger superfamily [IPR038603]", "FERM superfamily, second domain [IPR035963]", "FERM/acyl-CoA-binding protein superfamily [IPR014352]", "FF domain superfamily [IPR036517]", "FIP-RBD, C-terminal domain superfamily [IPR037245]", "FKBP12-rapamycin binding domain superfamily [IPR036738]", "FTO, C-terminal domain superfamily [IPR038413]", "Ferredoxin-NADP reductase (FNR), nucleotide-binding domain [IPR039261]", "Ferritin-like [IPR012347]", "Ferritin-like superfamily [IPR009078]", "Fibronectin type II domain superfamily [IPR036943]", "Fibronectin type III superfamily [IPR036116]", "Flavoprotein-like superfamily [IPR029039]", "Formin, FH2 domain superfamily [IPR042201]", "Formyl transferase, N-terminal domain superfamily [IPR036477]", "Formyl transferase-like, C-terminal domain superfamily [IPR011034]", "Fumarase/histidase, N-terminal [IPR024083]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily [IPR037099]", "Fumarylacetoacetase, N-terminal domain superfamily [IPR036462]", "Fumarylacetoacetase-like, C-terminal domain superfamily [IPR036663]", "G protein alpha subunit, helical insertion [IPR011025]", "GAD-like domain superfamily [IPR004115]", "GAR domain superfamily [IPR036534]", "GAT domain superfamily [IPR038425]", "GBBH-like, N-terminal domain superfamily [IPR038492]", "GHMP kinase, C-terminal domain superfamily [IPR036554]", "GINS complex, subunit Psf3 superfamily [IPR038437]", "GINS, helical bundle-like domain superfamily [IPR036224]", "GM2-AP, lipid-recognition domain superfamily [IPR036846]", "GMP phosphodiesterase, delta subunit superfamily [IPR037036]", "GOLD domain superfamily [IPR036598]", "GSKIP domain superfamily [IPR023231]", "GT29-like superfamiliy [IPR038578]", "GTF2I-like repeat superfamily [IPR036647]", "GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 [IPR027266]", "GTP-binding protein, orthogonal bundle domain superfamily [IPR023179]", "GYF-like domain superfamily [IPR035445]", "Galactose mutarotase-like domain superfamily [IPR011013]", "Galactose oxidase/kelch, beta-propeller [IPR011043]", "Galactose-binding-like domain superfamily [IPR008979]", "Gamma-glutamyl cyclotransferase-like superfamily [IPR036568]", "Gamma-tubulin complex component, C-terminal domain superfamily [IPR042241]", "Gelsolin-like domain superfamily [IPR036180]", "Globular protein, non-globular alpha/beta subunit [IPR011070]", "Glu-tRNAGln amidotransferase superfamily, subunit C [IPR036113]", "Glutamine synthetase/guanido kinase, catalytic domain [IPR014746]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1 [IPR042558]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2 [IPR042559]", "Glutathione S-transferase, C-terminal domain superfamily [IPR036282]", "Glutathione synthase, C-terminal, eukaryotic [IPR014709]", "Glutathione synthase, N-terminal, eukaryotic [IPR014049]", "Glutathione synthase, alpha-helical [IPR014042]", "Glutathione synthase, substrate-binding domain superfamily [IPR037013]", "Glycolipid transfer protein superfamily [IPR036497]", "Glycoside hydrolase 38, N-terminal domain superfamily [IPR027291]", "Glycoside hydrolase families 57/38, central domain superfamily [IPR028995]", "Glycoside hydrolase family 38, central domain superfamily [IPR037094]", "Glycoside hydrolase superfamily [IPR017853]", "Glycoside hydrolase/deacetylase, beta/alpha-barrel [IPR011330]", "Glycosyl hydrolase family 63, N-terminal domain superfamily [IPR038518]", "Glycosyl hydrolase, all-beta [IPR013780]", "Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [IPR029068]", "Golgi phosphoprotein 3-like domain superfamily [IPR038261]", "GroEL-like apical domain superfamily [IPR027409]", "GroEL-like equatorial domain superfamily [IPR027413]", "GroES chaperonin superfamily [IPR037124]", "GroES-like superfamily [IPR011032]", "Growth arrest and DNA damage-inducible proteins-interacting protein 1 domain superfamily [IPR043035]", "Growth factor receptor cysteine-rich domain superfamily [IPR009030]", "GrpE nucleotide exchange factor, coiled-coil [IPR013805]", "GrpE nucleotide exchange factor, head [IPR009012]", "Guanylate-binding protein, C-terminal domain superfamily [IPR036543]", "H/ACA RNP complex subunit Gar1/Naf1, Cbf5-binding domain [IPR038664]", "H/ACA ribonucleoprotein complex, subunit Nop10 superfamily [IPR036756]", "HAD superfamily [IPR023214]", "HAD-like superfamily [IPR036412]", "HAD-superfamily hydrolase, subfamily IA, REG-2-like, capping domain superfamily [IPR044924]", "HBS1-like protein, N-terminal domain superfamily [IPR037189]", "HECT, E3 ligase catalytic domain [IPR035983]", "HIT-like superfamily [IPR036265]", "HIV integrase-binding domain superfamily [IPR036218]", "HORMA domain superfamily [IPR036570]", "HR1 repeat superfamily [IPR036274]", "HRDC domain superfamily [IPR044876]", "HRDC-like superfamily [IPR010997]", "HSP20-like chaperone [IPR008978]", "HSP40/DnaJ peptide-binding [IPR008971]", "HSP90, C-terminal domain [IPR037196]", "Haem oxygenase-like, multi-helical [IPR016084]", "Heat shock protein 70kD, C-terminal domain superfamily [IPR029048]", "Heat shock protein 70kD, peptide-binding domain superfamily [IPR029047]", "Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410]", "Heavy metal-associated domain superfamily [IPR036163]", "Helix hairpin bin domain superfamily [IPR029012]", "Hemimethylated DNA-binding domain superfamily [IPR036623]", "High mobility group box domain superfamily [IPR036910]", "His-Me finger superfamily [IPR044925]", "Histidine kinase/HSP90-like ATPase superfamily [IPR036890]", "Histidine phosphatase superfamily [IPR029033]", "Histone acetyl transferase 1, N-terminal domain superfamily [IPR037113]", "Histone acetyltransferase HAT1, C-terminal [IPR013523]", "Histone chaperone ASF1-like superfamily [IPR036747]", "Histone deacetylase domain superfamily [IPR037138]", "Histone-fold [IPR009072]", "Homeobox-like domain superfamily [IPR009057]", "Homocysteine-binding domain superfamily [IPR036589]", "HotDog domain superfamily [IPR029069]", "Hydroxymethylglutaryl-CoA reductase, N-terminal [IPR023282]", "Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily [IPR009023]", "Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily [IPR023074]", "Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily [IPR009029]", "I/LWEQ domain superfamily [IPR035964]", "ISWI, HAND domain superfamily [IPR036306]", "Immunoglobulin E-set [IPR014756]", "Immunoglobulin-like domain superfamily [IPR036179]", "Immunoglobulin-like fold [IPR013783]", "Importin-alpha, importin-beta-binding domain superfamily [IPR036975]", "Initiation factor 2B-like, C-terminal [IPR042529]", "Inorganic polyphosphate/ATP-NAD kinase, N-terminal [IPR017438]", "Inorganic pyrophosphatase superfamily [IPR036649]", "Inosine triphosphate pyrophosphatase-like [IPR029001]", "Integrin alpha, N-terminal [IPR028994]", "Integrin beta tail domain superfamily [IPR036349]", "Integrin domain superfamily [IPR032695]", "Interferon regulatory factor 2-binding protein 1/2, C3HC4-type RING finger superfamily [IPR044882]", "Invasin/intimin cell-adhesion fragments [IPR008964]", "Isochorismatase-like superfamily [IPR036380]", "Isopenicillin N synthase-like superfamily [IPR027443]", "Isoprenoid synthase domain superfamily [IPR008949]", "Janus superfamily [IPR038596]", "K Homology domain, type 1 superfamily [IPR036612]", "K homology domain superfamily, prokaryotic type [IPR009019]", "K homology domain-like, alpha/beta [IPR015946]", "KA1 domain/Ssp2, C-terminal [IPR028375]", "Kelch-type beta propeller [IPR015915]", "Kinesin motor domain superfamily [IPR036961]", "Kinesin-like protein Kif23, Arf6-interacting domain superfamily [IPR038105]", "Kringle-like fold [IPR013806]", "Ku, C-terminal domain superfamily [IPR036494]", "Ku70, bridge and pillars domain superfamily [IPR027388]", "L-Aspartase-like [IPR008948]", "L21-like superfamily [IPR036164]", "L27 domain superfamily [IPR036892]", "LAP1C-like, C-terminal domain superfamily [IPR038599]", "LDL receptor-like superfamily [IPR036055]", "LEM/LEM-like domain superfamily [IPR011015]", "LIS1, N-terminal [IPR037190]", "LSM domain superfamily [IPR010920]", "Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal [IPR015955]", "Lambda repressor-like, DNA-binding domain superfamily [IPR010982]", "Lamin tail domain superfamily [IPR036415]", "LepA, C-terminal domain superfamily [IPR038363]", "Leucine-rich repeat domain superfamily [IPR032675]", "Longin-like domain superfamily [IPR011012]", "MAGE homology domain, winged helix WH1 motif [IPR041898]", "MAGE homology domain, winged helix WH2 motif [IPR041899]", "MAN1, winged-helix domain [IPR041885]", "MFS transporter superfamily [IPR036259]", "MHC class I-like antigen recognition-like superfamily [IPR037055]", "MHC classes I/II-like antigen recognition protein [IPR011162]", "MIT domain superfamily [IPR036181]", "MRG, C-terminal domain superfamily [IPR038217]", "MRP-L47 superfamily, mitochondrial [IPR038340]", "MTH938-like superfamily [IPR036748]", "Macro domain-like [IPR043472]", "Malic enzyme, N-terminal domain superfamily [IPR037062]", "Malonyl-CoA ACP transacylase, ACP-binding [IPR016036]", "Manganese/iron superoxide dismutase, C-terminal domain superfamily [IPR036314]", "Manganese/iron superoxide dismutase, N-terminal domain superfamily [IPR036324]", "Mannose-6-phosphate receptor binding domain superfamily [IPR009011]", "Membrane associated eicosanoid/glutathione metabolism-like domain superfamily [IPR023352]", "Metal-dependent hydrolase [IPR032466]", "Metal-dependent hydrolase, composite domain superfamily [IPR011059]", "Metallo-dependent phosphatase-like [IPR029052]", "Metalloenzyme, LuxS/M16 peptidase-like [IPR011249]", "Metallopeptidase, catalytic domain superfamily [IPR024079]", "Methionine synthase domain [IPR036594]", "Methionyl-tRNA synthetase, Zn-domain [IPR029038]", "Methylglyoxal synthase-like domain superfamily [IPR036914]", "Methylpurine-DNA glycosylase superfamily [IPR036995]", "Methylthiotransferase, N-terminal domain superfamily [IPR038135]", "Mib/herc2 domain superfamily [IPR037252]", "MitoNEET, CDGSH iron-sulfur domain [IPR042216]", "Mitochondrial carrier domain superfamily [IPR023395]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamily [IPR037169]", "Mitochondrial glycoprotein superfamily [IPR036561]", "Mitochondrial outer membrane translocase complex, Tom20 domain superfamily [IPR023392]", "MoaB/Mog-like domain superfamily [IPR036425]", "Moesin tail domain superfamily [IPR008954]", "Mre11, capping domain [IPR038487]", "Mss4-like superfamily [IPR011057]", "Mss4/translationally controlled tumour-associated TCTP [IPR011323]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily [IPR042179]", "MutS, connector domain superfamily [IPR036678]", "Myosin S1 fragment, N-terminal [IPR008989]", "NAC A/B domain superfamily [IPR038187]", "NAD kinase/diacylglycerol kinase-like domain superfamily [IPR016064]", "NAD(P)-binding domain superfamily [IPR036291]", "NADH-quinone oxidoreductase subunit E, N-terminal [IPR041921]", "NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily [IPR037225]", "NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily [IPR037207]", "NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily [IPR037232]", "NADP-dependent oxidoreductase domain superfamily [IPR036812]", "NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily [IPR023173]", "NAP-like superfamily [IPR037231]", "NET domain superfamily [IPR038336]", "NFRKB winged helix-like domain superfamily [IPR038106]", "NO signalling/Golgi transport ligand-binding domain superfamily [IPR024096]", "NOB1 zinc finger-like superfamily [IPR036283]", "NSFL1 cofactor p47, SEP domain superfamily [IPR036241]", "NTF2-like domain superfamily [IPR032710]", "NUDIX hydrolase-like domain superfamily [IPR015797]", "NVL2, N-terminal domain superfamily [IPR038100]", "NagB/RpiA transferase-like [IPR037171]", "Neurolysin/Thimet oligopeptidase, N-terminal [IPR024080]", "Neurolysin/Thimet oligopeptidase, domain 2 [IPR024077]", "Nibrin, second BRCT domain superfamily [IPR043014]", "Nicotinate phosphoribosyltransferase-like, C-terminal [IPR036068]", "Nitrogen regulatory PII-like, alpha/beta [IPR011322]", "Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal [IPR015867]", "Nitrous oxide reductase, N-terminal [IPR011045]", "Nop domain superfamily [IPR036070]", "Nop, C-terminal domain [IPR042239]", "Nucleic acid-binding, OB-fold [IPR012340]", "Nucleophile aminohydrolases, N-terminal [IPR029055]", "Nucleoplasmin core domain superfamily [IPR036824]", "Nucleoporin, Nup155-like, C-terminal, subdomain 1 [IPR042533]", "Nucleoporin, Nup155-like, C-terminal, subdomain 2 [IPR042537]", "Nucleoporin, Nup155-like, C-terminal, subdomain 3 [IPR042538]", "Nucleoside diphosphate kinase-like domain superfamily [IPR036850]", "Nucleoside phosphorylase superfamily [IPR035994]", "Nucleotide-binding alpha-beta plait domain superfamily [IPR012677]", "Nucleotide-diphospho-sugar transferases [IPR029044]", "Nucleotidyltransferase superfamily [IPR043519]", "Nucleotidyltransferase, class I-like, C-terminal [IPR011068]", "NusG, N-terminal domain superfamily [IPR036735]", "Oxygen-dependent coproporphyrinogen III oxidase superfamily [IPR036406]", "Oxysterol-binding protein superfamily [IPR037239]", "P-loop containing nucleoside triphosphate hydrolase [IPR027417]", "P-type ATPase, A domain superfamily [IPR008250]", "P-type ATPase, cytoplasmic domain N [IPR023299]", "P-type ATPase, transmembrane domain superfamily [IPR023298]", "P-type trefoil domain superfamily [IPR044913]", "PABC (PABP) domain [IPR036053]", "PADR1 domain superfamily [IPR038650]", "PAZ domain superfamily [IPR036085]", "PBDC1-like domain superfamily [IPR023139]", "PD-(D/E)XK endonuclease-like domain superfamily [IPR011604]", "PDCD5-like superfamily [IPR036883]", "PDZ superfamily [IPR036034]", "PEBP-like superfamily [IPR036610]", "PFU domain superfamily [IPR038122]", "PH-like domain superfamily [IPR011993]", "PHR domain superfamily [IPR038648]", "PIN-like domain superfamily [IPR029060]", "PITH domain superfamily [IPR037047]", "PKD domain superfamily [IPR035986]", "PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily [IPR017946]", "PNPase/RNase PH domain superfamily [IPR027408]", "POLO box domain superfamily [IPR036947]", "PPM-type phosphatase domain superfamily [IPR036457]", "PRC-barrel-like superfamily [IPR011033]", "PRP4-like superfamily [IPR036285]", "PTPA superfamily [IPR037218]", "PUA domain superfamily [IPR036974]", "PUA-like superfamily [IPR015947]", "PWI domain superfamily [IPR036483]", "PX domain superfamily [IPR036871]", "Paired amphipathic helix superfamily [IPR036600]", "PapD-like superfamily [IPR008962]", "Papain-like cysteine peptidase superfamily [IPR038765]", "Pectin lyase fold [IPR012334]", "Pectin lyase fold/virulence factor [IPR011050]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily [IPR036959]", "Peptidase C65, otubain, subdomain 2 [IPR042467]", "Peptidase C65, otubain, subdomain 1 [IPR042468]", "Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily [IPR038502]", "Peptidase M13, domain 2 [IPR042089]", "Peptidase M4/M1, CTD superfamily [IPR027268]", "Peptidase M41-like [IPR037219]", "Peptidase M60, enhancin-like domain 3 [IPR042279]", "Peptidase S1, PA clan [IPR009003]", "Peptidase S59, nucleoporin superfamily [IPR036903]", "Peptidase S8/S53 domain superfamily [IPR036852]", "Peptidyl-tRNA hydrolase II domain superfamily [IPR023476]", "Pex19, C-terminal domain superfamily [IPR038322]", "Phenylalanyl-tRNA synthetase-like, B3/B4 [IPR020825]", "Phosphatidic acid phosphatase type 2/haloperoxidase superfamily [IPR036938]", "Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily [IPR036940]", "Phosphatidylinositol-4-phosphate 5-kinase, N-terminal [IPR027484]", "Phosphoenolpyruvate carboxykinase, C-terminal [IPR013035]", "Phosphoenolpyruvate carboxykinase, N-terminal [IPR008210]", "Phosphofructokinase superfamily [IPR035966]", "Phosphoglucose isomerase, C-terminal [IPR023096]", "Phosphoglycerate kinase superfamily [IPR036043]", "Phosphoglycerate kinase, N-terminal [IPR015824]", "Phosphoinositide 3-kinase, accessory (PIK) domain superfamily [IPR042236]", "Phospholipase B-like, domain 1 [IPR043040]", "Phospholipase B-like, domain 2 [IPR043041]", "Phospholipase B-like, domain 3 [IPR043042]", "Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily [IPR036604]", "Phosphoribosylglycinamide synthetase, C-domain superfamily [IPR037123]", "Phosphoribosyltransferase-like [IPR029057]", "Phosphorylated adapter RNA export protein, RNA-binding domain superfamily [IPR038092]", "Phosphotransferase/anion transporter [IPR016152]", "Phosphotyrosine protein phosphatase I superfamily [IPR036196]", "Phosphotyrosyl phosphatase activator, C-terminal lid domain [IPR043170]", "Plakin repeat superfamily [IPR035915]", "Plus3-like superfamily [IPR036128]", "Poly(ADP-ribose) polymerase, regulatory domain superfamily [IPR036616]", "Polyketide synthase, dehydratase domain superfamily [IPR042104]", "Polymerase/histidinol phosphatase-like [IPR016195]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily [IPR036456]", "Porin domain superfamily [IPR023614]", "Porphobilinogen deaminase, C-terminal domain superfamily [IPR036803]", "Pre-ATP-grasp domain superfamily [IPR016185]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily [IPR042516]", "Prefoldin [IPR009053]", "Profilin superfamily [IPR036140]", "Prolyl-tRNA synthetase, class II [IPR017449]", "Proteasome activator PA28, C-terminal domain superfamily [IPR036997]", "Proteasome activator PA28, N-terminal domain superfamily [IPR036996]", "Proteasome activator superfamily [IPR036252]", "Protein arginine methyltransferase NDUFAF7 superfamily [IPR038375]", "Protein kinase-like domain superfamily [IPR011009]", "Protein-tyrosine phosphatase-like [IPR029021]", "Prp8 RNase domain IV, fingers region [IPR043173]", "Prp8 RNase domain IV, palm region [IPR043172]", "Pseudouridine synthase I, TruA, C-terminal [IPR020095]", "Pseudouridine synthase TruA/RsuA/RluB/E/F, N-terminal [IPR020094]", "Pseudouridine synthase, TruD, catalytic domain [IPR042214]", "Pseudouridine synthase, catalytic domain superfamily [IPR020103]", "Pterin 4 alpha carbinolamine dehydratase superfamily [IPR036428]", "PurM-like, C-terminal domain superfamily [IPR036676]", "PurM-like, N-terminal domain superfamily [IPR036921]", "Putative DNA-binding domain superfamily [IPR009061]", "Pyridoxal phosphate-dependent transferase [IPR015424]", "Pyridoxal phosphate-dependent transferase, major domain [IPR015421]", "Pyridoxal phosphate-dependent transferase, small domain [IPR015422]", "Pyruvate kinase, C-terminal domain superfamily [IPR036918]", "Pyruvate kinase, insert domain superfamily [IPR015806]", "Pyruvate kinase-like domain superfamily [IPR040442]", "Pyruvate kinase-like, insert domain superfamily [IPR011037]", "Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily [IPR015813]", "Queuine tRNA-ribosyltransferase-like [IPR036511]", "Quinoprotein alcohol dehydrogenase-like superfamily [IPR011047]", "Quinoprotein amine dehydrogenase, beta chain-like [IPR011044]", "R3H domain superfamily [IPR036867]", "RAP domain superfamily [IPR036744]", "RBP-J/Cbf11, DNA binding domain superfamily [IPR037095]", "RGS domain superfamily [IPR036305]", "RNA 3'-terminal phosphate cyclase domain superfamily [IPR037136]", "RNA 3'-terminal phosphate cyclase, insert domain superfamily [IPR036553]", "RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta [IPR013792]", "RNA polymerase Rpb1, clamp domain superfamily [IPR044893]", "RNA polymerase Rpb1, domain 3 superfamily [IPR042102]", "RNA polymerase Rpb1, domain 7 superfamily [IPR038593]", "RNA polymerase Rpb1, funnel domain superfamily [IPR038120]", "RNA polymerase Rpb2, OB-fold [IPR014724]", "RNA polymerase Rpb2, domain 2 superfamily [IPR037034]", "RNA polymerase Rpb5, N-terminal domain superfamily [IPR036710]", "RNA polymerase Rpb7-like, N-terminal domain superfamily [IPR036898]", "RNA polymerase subunit RPB10 [IPR023580]", "RNA polymerase, RBP11-like subunit [IPR036603]", "RNA-binding S4 domain superfamily [IPR036986]", "RNA-binding domain superfamily [IPR035979]", "RPB5-like RNA polymerase subunit superfamily [IPR035913]", "RUN domain superfamily [IPR037213]", "Rab geranylgeranyltransferase, alpha subunit, insert-domain superfamily [IPR036254]", "Rab-GTPase-TBC domain superfamily [IPR035969]", "Radical SAM, alpha/beta horseshoe [IPR023404]", "Ran-GTPase activating protein 1, C-terminal domain superfamily [IPR036720]", "Rap/Ran-GAP superfamily [IPR035974]", "Ras guanine nucleotide exchange factor domain superfamily [IPR023578]", "Ras guanine-nucleotide exchange factor, catalytic domain superfamily [IPR036964]", "Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II [IPR009091]", "Regulatory factor, effector binding domain superfamily [IPR011256]", "Restriction endonuclease type II-like [IPR011335]", "Rho GDP-dissociation inhibitor domain superfamily [IPR024792]", "Rho GTPase activation protein [IPR008936]", "Rhodanese-like domain superfamily [IPR036873]", "Rhomboid-like superfamily [IPR035952]", "Riboflavin synthase-like beta-barrel [IPR017938]", "Ribokinase-like [IPR029056]", "Ribonuclease H superfamily [IPR036397]", "Ribonuclease H-like superfamily [IPR012337]", "Ribonuclease H1, N-terminal domain superfamily [IPR037056]", "Ribonuclease HII, helix-loop-helix cap domain superfamily [IPR023160]", "Ribonuclease III, endonuclease domain superfamily [IPR036389]", "Ribonuclease T2-like superfamily [IPR036430]", "Ribonuclease Z/Hydroxyacylglutathione hydrolase-like [IPR036866]", "Ribonucleotide reductase R1 subunit, N-terminal [IPR008926]", "Ribonucleotide reductase-like [IPR012348]", "Ribosomal L15/L27a, N-terminal [IPR027386]", "Ribosomal L18e/L15P superfamily [IPR036227]", "Ribosomal RNA-processing protein 8, N-terminal domain [IPR042036]", "Ribosomal protein L1, 3-layer alpha/beta-sandwich [IPR016095]", "Ribosomal protein L1-like [IPR023674]", "Ribosomal protein L10-like domain superfamily [IPR043141]", "Ribosomal protein L10e/L16 superfamily [IPR036920]", "Ribosomal protein L11, C-terminal domain superfamily [IPR036769]", "Ribosomal protein L11/L12, N-terminal domain superfamily [IPR036796]", "Ribosomal protein L13 superfamily [IPR036899]", "Ribosomal protein L14 superfamily [IPR036853]", "Ribosomal protein L15e core domain superfamily [IPR024794]", "Ribosomal protein L19 superfamily [IPR038657]", "Ribosomal protein L19/L19e superfamily [IPR035970]", "Ribosomal protein L19/L19e, domain 1 [IPR015972]", "Ribosomal protein L2, domain 2 [IPR014722]", "Ribosomal protein L2, domain 3 [IPR014726]", "Ribosomal protein L20, C-terminal [IPR035566]", "Ribosomal protein L21 superfamily [IPR036948]", "Ribosomal protein L22/L17 superfamily [IPR036394]", "Ribosomal protein L22e superfamily [IPR038526]", "Ribosomal protein L23/L15e core domain superfamily [IPR012678]", "Ribosomal protein L24e/L24 superfamily [IPR038630]", "Ribosomal protein L25/Gln-tRNA synthetase, N-terminal [IPR020056]", "Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily [IPR011035]", "Ribosomal protein L27e superfamily [IPR038655]", "Ribosomal protein L29/L35 superfamily [IPR036049]", "Ribosomal protein L3, domain 3, archaeal type superfamily [IPR044892]", "Ribosomal protein L30, ferredoxin-like fold domain superfamily [IPR036919]", "Ribosomal protein L31e domain superfamily [IPR023621]", "Ribosomal protein L32e superfamily [IPR036351]", "Ribosomal protein L33 superfamily [IPR038584]", "Ribosomal protein L35A superfamily [IPR038661]", "Ribosomal protein L36e domain superfamily [IPR038097]", "Ribosomal protein L37ae/L37e [IPR011331]", "Ribosomal protein L38e superfamily [IPR038464]", "Ribosomal protein L4 domain superfamily [IPR023574]", "Ribosomal protein L5 domain superfamily [IPR022803]", "Ribosomal protein L6, alpha-beta domain superfamily [IPR036789]", "Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like [IPR014719]", "Ribosomal protein L7/L12, oligomerisation domain superfamily [IPR036235]", "Ribosomal protein L9, N-terminal domain superfamily [IPR036935]", "Ribosomal protein L9/RNase H1, N-terminal [IPR009027]", "Ribosomal protein P1/P2, N-terminal domain [IPR038716]", "Ribosomal protein S10 domain superfamily [IPR036838]", "Ribosomal protein S11 superfamily [IPR036967]", "Ribosomal protein S13-like, H2TH [IPR010979]", "Ribosomal protein S17e-like superfamily [IPR036401]", "Ribosomal protein S19/S15, superfamily [IPR023575]", "Ribosomal protein S2, flavodoxin-like domain superfamily [IPR023591]", "Ribosomal protein S21 superfamily [IPR038380]", "Ribosomal protein S21e superfamily [IPR038579]", "Ribosomal protein S27, zinc-binding domain superfamily [IPR023407]", "Ribosomal protein S3, C-terminal domain superfamily [IPR036419]", "Ribosomal protein S4e, central domain superfamily [IPR038237]", "Ribosomal protein S5 domain 2-type fold [IPR020568]", "Ribosomal protein S5 domain 2-type fold, subgroup [IPR014721]", "Ribosomal protein S7 domain superfamily [IPR036823]", "Ribosomal protein S8 superfamily [IPR035987]", "Ribosomal protein S8e subdomain, eukaryotes [IPR042563]", "Ribosome maturation protein SBDS, N-terminal domain superfamily [IPR036786]", "Ribosome maturation protein Sdo1/SBDS, central domain superfamily [IPR037188]", "Ribosome-associated complex head domain superfamily [IPR042569]", "Ribosome-binding factor A domain superfamily [IPR023799]", "Ribulose-phosphate binding barrel [IPR011060]", "Ricin B-like lectins [IPR035992]", "RmlC-like cupin domain superfamily [IPR011051]", "RmlC-like jelly roll fold [IPR014710]", "Rossmann-like alpha/beta/alpha sandwich fold [IPR014729]", "Rpb4/RPC9 superfamily [IPR038324]", "Rudiment single hybrid motif [IPR011054]", "RutC-like superfamily [IPR035959]", "RuvA domain 2-like [IPR010994]", "RuvBL1/2, DNA/RNA binding domain [IPR042487]", "S-adenosyl-L-methionine-dependent methyltransferase [IPR029063]", "S-adenosylmethionine synthetase superfamily [IPR022636]", "S15/NS1, RNA-binding [IPR009068]", "SAP domain superfamily [IPR036361]", "SCP2 sterol-binding domain superfamily [IPR036527]", "SGNH hydrolase superfamily [IPR036514]", "SH2 domain superfamily [IPR036860]", "SH3-like domain superfamily [IPR036028]", "SKP1-like, dimerisation domain superfamily [IPR036296]", "SKP1/BTB/POZ domain superfamily [IPR011333]", "SLED domain superfamily [IPR038348]", "SMAD/FHA domain superfamily [IPR008984]", "SMCs flexible hinge superfamily [IPR036277]", "SNARE [IPR010989]", "SNF2-like, N-terminal domain superfamily [IPR038718]", "SNase-like, OB-fold superfamily [IPR035437]", "SOS response associated peptidase-like [IPR036590]", "SPOC-like, C-terminal domain superfamily [IPR016194]", "SRA-YDG superfamily [IPR036987]", "SRCR-like domain superfamily [IPR036772]", "SRP/SRP receptor, N-terminal [IPR036225]", "SRP68, N-terminal domain superfamily [IPR038253]", "SSRP1 domain superfamily [IPR038167]", "START-like domain superfamily [IPR023393]", "STAT transcription factor, DNA-binding, N-terminal [IPR012345]", "STAT transcription factor, N-terminal domain superfamily [IPR036535]", "STAT transcription factor, coiled coil [IPR015988]", "STAT1, C-terminal domain superfamily [IPR038295]", "SUI1 domain superfamily [IPR036877]", "SWAP/Surp superfamily [IPR035967]", "SWIB/MDM2 domain superfamily [IPR036885]", "Scavenger mRNA decapping enzyme, N-terminal [IPR011145]", "Schlafen, AlbA_2 domain superfamily [IPR038461]", "ScpA-like, C-terminal [IPR023093]", "Sec1-like superfamily [IPR036045]", "Sec1-like, domain 1 [IPR043154]", "Sec1-like, domain 2 [IPR027482]", "Sec1-like, domain 3a [IPR043127]", "Sec23/Sec24 helical domain superfamily [IPR036175]", "Sec7 domain superfamily [IPR035999]", "Sec7, C-terminal domain superfamily [IPR023394]", "SecY domain superfamily [IPR023201]", "Sema domain superfamily [IPR036352]", "Serine carboxypeptidase S28, SKS domain [IPR042269]", "Serine-tRNA synthetase, type1, N-terminal domain superfamily [IPR042103]", "Serpin superfamily [IPR036186]", "Serpin superfamily, domain 1 [IPR042178]", "Serpin superfamily, domain 2 [IPR042185]", "Seven-hairpin glycosidases [IPR036026]", "Signal recognition particle SRP54, N-terminal domain superfamily [IPR042101]", "Signal recognition particle, SRP54 subunit, M-domain superfamily [IPR036891]", "Signal recognition particle, SRP9/SRP14 subunit [IPR009018]", "Sin3 associated polypeptide p18 superfamily [IPR042534]", "Single hybrid motif [IPR011053]", "Sirtuin, catalytic core small domain superfamily [IPR026591]", "Six-bladed beta-propeller, TolB-like [IPR011042]", "Six-hairpin glycosidase superfamily [IPR008928]", "Six-hairpin glycosidase-like superfamily [IPR012341]", "Smac/DIABLO-like superfamily [IPR009062]", "Sodium/potassium-transporting ATPase subunit beta superfamily [IPR038702]", "Sodium:dicarboxylate symporter superfamily [IPR036458]", "Soluble quinoprotein glucose/sorbosone dehydrogenase [IPR011041]", "Spermadhesin, CUB domain superfamily [IPR035914]", "Spermidine synthase, tetramerisation domain superfamily [IPR037163]", "Spt6, Death-like domain [IPR042066]", "Stathmin superfamily [IPR036002]", "Sterile alpha motif/pointed domain superfamily [IPR013761]", "Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily [IPR027477]", "Succinyl-CoA synthetase-like [IPR016102]", "Sulfatase-modifying factor enzyme superfamily [IPR042095]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain superfamily [IPR042568]", "TBP domain superfamily [IPR012295]", "TCP-1-like chaperonin intermediate domain superfamily [IPR027410]", "TEL2, C-terminal domain superfamily [IPR038528]", "TFIIIC, subcomplex tauA subunit Sfc1, triple barrel domain superfamily [IPR042536]", "TFIIS/LEDGF domain superfamily [IPR035441]", "TGS-like [IPR012676]", "TGS-like domain superfamily [IPR023192]", "TMEM14 superfamily [IPR044890]", "TRAF-like [IPR008974]", "TRF2-interacting telomeric protein/Rap1, C-terminal domain superfamily [IPR038104]", "TROVE domain superfamily [IPR037214]", "Talin, central domain superfamily [IPR036476]", "Taurine dioxygenase TauD-like superfamily [IPR042098]", "Tautomerase/MIF superfamily [IPR014347]", "Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid [IPR008930]", "Tetraspanin, EC2 domain superfamily [IPR008952]", "Tetratricopeptide-like helical domain superfamily [IPR011990]", "Tex-like domain superfamily [IPR023323]", "Tex-like protein, HTH domain superfamily [IPR023319]", "Thiamin diphosphate-binding fold [IPR029061]", "Thiolase-like [IPR016039]", "Thioredoxin-like superfamily [IPR036249]", "Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily [IPR018163]", "Thymidylate synthase/dCMP hydroxymethylase superfamily [IPR036926]", "Tim10-like domain superfamily [IPR035427]", "Tma16 superfamily [IPR038356]", "Transcription Factor IIF, Rap30/Rap74, interaction [IPR011039]", "Transcription elongation factor S-II, central domain superfamily [IPR036575]", "Transcription termination and cleavage factor, C-terminal domain superfamily [IPR038192]", "Transferrin receptor-like, dimerisation domain superfamily [IPR036757]", "Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II [IPR009014]", "Translation Initiation factor eIF- 4e-like [IPR023398]", "Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal [IPR009001]", "Translation elongation factor EF1B/ribosomal protein S6 [IPR014717]", "Translation elongation factor eEF-1beta-like superfamily [IPR036219]", "Translation initiation factor 2, alpha subunit, C-terminal [IPR024055]", "Translation initiation factor 2, alpha subunit, middle domain superfamily [IPR024054]", "Translation initiation factor 3, subunit 12, N-terminal, eukaryotic [IPR016020]", "Translation initiation factor IF-2, domain 3 superfamily [IPR036925]", "Translation initiation factor IF2/IF5, N-terminal [IPR016189]", "Translation initiation factor IF2/IF5, zinc-binding [IPR016190]", "Translation initiation factor eIF-2B subunit alpha, N-terminal [IPR042528]", "Translation protein SH3-like domain superfamily [IPR008991]", "Translation protein, beta-barrel domain superfamily [IPR009000]", "Translin superfamily [IPR036081]", "Translin, C-terminal [IPR016069]", "Translin, N-terminal [IPR016068]", "Trimeric LpxA-like superfamily [IPR011004]", "Triosephosphate isomerase superfamily [IPR035990]", "TspO/MBR-related superfamily [IPR038330]", "Tubulin binding cofactor A superfamily [IPR036126]", "Tubulin, C-terminal [IPR023123]", "Tubulin/FtsZ, C-terminal [IPR008280]", "Tubulin/FtsZ, GTPase domain superfamily [IPR036525]", "Tubulin/FtsZ-like, C-terminal domain [IPR037103]", "UBA-like superfamily [IPR009060]", "UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily [IPR036220]", "UROD/MetE-like superfamily [IPR038071]", "Ubiquitin activating enzyme, alpha domain superfamily [IPR023318]", "Ubiquitin-activating enzyme E1, C-terminal domain superfamily [IPR038252]", "Ubiquitin-activating enzyme E1, FCCH domain superfamily [IPR042302]", "Ubiquitin-activating enzyme E1, SCCH domain [IPR042063]", "Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 [IPR042449]", "Ubiquitin-activating enzyme [IPR035985]", "Ubiquitin-conjugating enzyme/RWD-like [IPR016135]", "Ubiquitin-like domain superfamily [IPR029071]", "Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain superfamily [IPR042556]", "Ufd1-like, Nn domain [IPR042299]", "Uracil-DNA glycosylase-like domain superfamily [IPR036895]", "Ureohydrolase domain superfamily [IPR023696]", "V-type ATP synthase c/d subunit, domain 3 superfamily [IPR044911]", "V-type ATP synthase subunit c/d subunit superfamily [IPR036079]", "V-type ATPase subunit C/d [IPR035067]", "V-type ATPase subunit E, C-terminal domain superfamily [IPR038495]", "VASP tetramerisation domain superfamily [IPR038023]", "VKOR domain superfamily [IPR038354]", "VPS9 domain superfamily [IPR037191]", "Vacuolar ATP synthase subunit C superfamily [IPR036132]", "Vacuolar protein sorting-associated protein 33, domain 3b [IPR043155]", "Vacuolar protein sorting-associated protein 35, C-terminal [IPR042491]", "Vacuolar protein sorting-associated protein IST1-like [IPR042277]", "Valyl-tRNA synthetase, tRNA-binding arm superfamily [IPR037118]", "Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain [IPR009008]", "Vanillyl-alcohol oxidase, C-terminal subdomain 2 [IPR016171]", "Vesicle transport v-SNARE, N-terminal domain superfamily [IPR038407]", "Vitamin B12-dependent methionine synthase, activation domain superfamily [IPR037010]", "Vps16, C-terminal domain superfamily [IPR038132]", "Vps53, C-terminal domain superfamily [IPR038260]", "WD40-repeat-containing domain superfamily [IPR036322]", "WD40/YVTN repeat-like-containing domain superfamily [IPR015943]", "WGR domain superfamily [IPR036930]", "WW domain superfamily [IPR036020]", "WWE domain superfamily [IPR037197]", "Winged helix DNA-binding domain superfamily [IPR036390]", "Winged helix-like DNA-binding domain superfamily [IPR036388]", "XPA domain superfamily [IPR037129]", "XPC-binding domain superfamily [IPR036353]", "YjeF N-terminal domain superfamily [IPR036652]", "YqgF/RNase H-like domain superfamily [IPR037027]", "ZPR1, A/B domain [IPR042451]", "ZPR1, zinc finger domain [IPR042452]", "Zinc finger C2H2 superfamily [IPR036236]", "Zinc finger, C2H2C-type superfamily [IPR036060]", "Zinc finger, CCCH-type superfamily [IPR036855]", "Zinc finger, CCHC-type superfamily [IPR036875]", "Zinc finger, FYVE/PHD-type [IPR011011]", "Zinc finger, NHR/GATA-type [IPR013088]", "Zinc finger, PARP-type superfamily [IPR036957]", "Zinc finger, RING/FYVE/PHD-type [IPR013083]", "Zinc finger, RanBP2-type superfamily [IPR036443]", "Zinc finger, Sec23/Sec24-type superfamily [IPR036174]", "Zinc finger, ZZ-type superfamily [IPR043145]", "Zinc-binding ribosomal protein [IPR011332]", "dUTPase-like superfamily [IPR036157]", "eRF1, domain 1 [IPR024049]", "eRF1, domain 2 superfamily [IPR042226]", "p53-like tetramerisation domain superfamily [IPR036674]", "p53-like transcription factor, DNA-binding [IPR008967]", "p53/RUNT-type transcription factor, DNA-binding domain superfamily [IPR012346]", "rRNA adenine dimethylase-like, C-terminal [IPR023165]", "ssDNA-binding transcriptional regulator [IPR009044]", "tRNA (guanine-N1-)-methyltransferase, N-terminal [IPR029026]", "tRNA methyltransferase TRM10-type domain superfamily [IPR038459]", "tRNA methyltransferase, Trm1, C-terminal [IPR042296]", "tRNA modification GTPase MnmE domain 2 [IPR027368]", "tRNA-splicing ligase RtcB-like superfamily [IPR036025]", "von Willebrand factor A-like domain superfamily [IPR036465]"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGFG1", "AGK", "AGL", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AKAP1", "AKAP17A", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALKBH5", "ALYREF", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD13A", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APC", "APEH", "APEX1", "API5", "APMAP", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARG2", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID4B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARL6", "ARL8B", "ARMC1", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASCC1", "ASCC2", "ASCC3", "ASF1A", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATG13", "ATG4B", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5H", "ATP5O", "ATP6", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATP7B", "ATXN10", "ATXN2", "AURKA", "BAG5", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCKDK", "BCL10", "BCL2L13", "BCS1L", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BOLA2*", "BOP1", "BPHL", "BRAP", "BRAT1", "BRCA1", "BRD1", "BRD2", "BRD3", "BRD4", "BRD7", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BZW1", "BZW2", "C1QBP", "C2CD5", "CAB39", "CACYBP", "CAD", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAMSAP3", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CC2D1A", "CCAR1", "CCAR2", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD276", "CD2AP", "CD2BP2", "CD47", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK16", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK7", "CDK9", "CDKAL1", "CEBPZ", "CELF1", "CELF2", "CENPV", "CEP170", "CETN2", "CFL1", "CFL2", "CHAC2", "CHAF1B", "CHAMP1", "CHD1", "CHD1L", "CHD4", "CHD8", "CHEK2", "CHERP", "CHID1", "CHKA", "CHORDC1", "CHP1", "CHRAC1", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CIZ1", "CKAP5", "CKB", "CKMT1A*", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT3", "CNOT7", "CNOT9", "CNP", "COA7", "COASY", "COG8", "COLEC12", "COLGALT1", "COMT", "COMTD1", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPZ1", "COQ8A", "CORO1C", "COTL1", "COX11", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7A2L", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK1E", "CSNK2A2", "CSNK2B", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUL7", "CUTA", "CWF19L1", "CXADR", "CXorf57", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYP20A1", "CYP51A1", "DAG1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCP1B", "DCPS", "DCTN1", "DCUN1D5", "DCXR", "DDB1", "DDI2", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DENR", "DERL1", "DFFA", "DGCR8", "DHCR24", "DHFR", "DHODH", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLST", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DOCK1", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH2", "DPM1", "DPP9", "DPYSL2", "DR1", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUS2", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDC4", "EDF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFHD2", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHHADH", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3B", "EIF3E", "EIF3G", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMO2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC3", "ERCC6L", "ERH", "ERLIN1", "ERLIN2", "ERO1A", "ERP29", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC6", "EXOC6B", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM120A", "FAM129B", "FAR1", "FARP2", "FARSA", "FARSB", "FASN", "FBL", "FBXO22", "FBXO7", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FH", "FHOD1", "FKBP10", "FKBP14", "FKBP4", "FKBP5", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FNBP1", "FNBP4", "FNDC3A", "FNTB", "FOXK1", "FOXK2", "FOXRED1", "FRG1", "FSCN1", "FTL", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCDH", "GCLC", "GCN1", "GDAP1", "GDE1", "GDI1", "GDI2", "GDPD1", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GGH", "GGPS1", "GIGYF2", "GINS1", "GINS2", "GINS3", "GINS4", "GIPC1", "GLA", "GLB1", "GLDC", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLTP", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAO1", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GNPNAT1", "GNS", "GOLPH3", "GORASP2", "GOSR2", "GOT1", "GOT2", "GPATCH8", "GPD1L", "GPD2", "GPI", "GPKOW", "GPRASP2", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2I", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAT1", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGFL2", "HDHD2", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMCES", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCR", "HMGCS1", "HMGXB4", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDE", "IDI1", "IFT27", "IFT88", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMP3", "IMPDH1", "IMPDH2", "INF2", "INPP4A", "INTS1", "INTS11", "INTS12", "INTS14", "INTS8", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "IRF2BPL", "IRS4", "ISOC1", "IST1", "ISYNA1", "ITGAV", "ITGB1", "ITPA", "IVD", "IWS1", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1468", "KIF11", "KIF14", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC4", "KLHDC4", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRR1", "KYAT3", "L2HGDH", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LCMT2", "LDAH", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC57", "LRRC59", "LRRC8C", "LRWD1", "LSM14B", "LSM2", "LSM4", "LSM6", "LSS", "LTA4H", "LYAR", "LYPLA1", "LYPLA2", "LZIC", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAN1A1", "MAN1A2", "MAN2A1", "MANF", "MAP2K1", "MAP2K2", "MAP3K7", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARK2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED16", "MEPCE", "METAP2", "METTL1", "METTL13", "METTL3", "MFN2", "MFSD10", "MFSD5", "MFSD8", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MMAB", "MMS19", "MOGS", "MORC2", "MORF4L1", "MOSPD2", "MOV10", "MPG", "MPI", "MPP1", "MPP2", "MPP6", "MPRIP", "MPST", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL3", "MRPL33", "MRPL38", "MRPL39", "MRPL4", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL9", "MRPS11", "MRPS15", "MRPS17", "MRPS2", "MRPS21", "MRPS25", "MRPS27", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSI2", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MUT", "MVD", "MYBBP1A", "MYCBP2", "MYEF2", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAF1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPG2", "NCBP1", "NCDN", "NCKIPSD", "NCL", "NCOA5", "NCOR1", "NDRG3", "NDUFA10", "NDUFA2", "NDUFA9", "NDUFAF3", "NDUFAF7", "NDUFS1", "NDUFS3", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEDD4L", "NEK9", "NELFE", "NENF", "NF1", "NFATC2IP", "NFRKB", "NFS1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP2", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL8", "NOL9", "NOM1", "NONO", "NOP10", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC2", "NPEPPS", "NPHP3", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRP1", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDCD2", "NUDCD3", "NUDT1", "NUDT16L1", "NUDT19", "NUDT21", "NUDT5", "NUDT9", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXCT1", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAK1IP1", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARL", "PARN", "PARP1", "PARP2", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCMT1", "PCYOX1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDS5A", "PDS5B", "PDSS2", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PHAX", "PHB", "PHB2", "PHC2", "PHF10", "PHF3", "PHF6", "PHGDH", "PHIP", "PHPT1", "PI4KA", "PICALM", "PIGG", "PIK3C2A", "PIK3R2", "PIP4K2C", "PIR", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNO1", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE4", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR2L", "POLR3A", "POLR3C", "POLRMT", "PON2", "POR", "PPA1", "PPA2", "PPAT", "PPFIA1", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R14B", "PPP1R9B", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRKAA2", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPSAP1", "PRPSAP2", "PRRC1", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSME1", "PSME2", "PSME3", "PSPC1", "PSPH", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PTRHD1", "PUF60", "PUM1", "PUM3", "PUS1", "PUS7", "PWP1", "PWP2", "PYCR1", "PYCR2", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB3B", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RABGAP1", "RABGEF1", "RABGGTA", "RABL3", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALGAPB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANGAP1", "RAP1GDS1", "RAP2B", "RAPGEF2", "RARS", "RASA1", "RAVER1", "RBBP5", "RBBP6", "RBFA", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM47", "RBM5", "RBM6", "RBM7", "RBM8A", "RBMX", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REPS1", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT2", "RIDA", "RIF1", "RINT1", "RIOK2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF219", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPA3", "RPAP3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS27", "RPS28", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRAS2", "RRM1", "RRM2", "RRP12", "RRP7A", "RRP8", "RRP9", "RSF1", "RSL1D1", "RSU1", "RTCA", "RTCB", "RTF1", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART3", "SBDS", "SBNO1", "SCAF11", "SCAF4", "SCAP", "SCCPDH", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCYL2", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC13", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3B1", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHCBP1", "SHMT1", "SHMT2", "SHOC2", "SIN3A", "SIN3B", "SIRT1", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC2A8", "SLC30A5", "SLC30A9", "SLC3A2", "SLC4A1AP", "SLC4A7", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMG5", "SMS", "SMU1", "SND1", "SNIP1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNX1", "SNX17", "SNX2", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPECC1L", "SPEN", "SPR", "SPRYD7", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "ST3GAL4", "STAG1", "STAG2", "STAM", "STARD7", "STAT1", "STAT3", "STIP1", "STK26", "STK38", "STK4", "STMN1", "STOML2", "STRAP", "STRBP", "STRN", "STUB1", "STX10", "STX12", "STX4", "STX5", "STX6", "STX7", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUMF2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SYAP1", "SYMPK", "SYNCRIP", "SYNE1", "SYNE2", "SYNJ2BP", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TARDBP", "TARS", "TARS2", "TARSL2", "TBC1D10A", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TCAF1", "TCEA1", "TCERG1", "TCP1", "TDP2", "TECR", "TEFM", "TELO2", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFRC", "THEM6", "THOC1", "THOC3", "THOC6", "THOP1", "THTPA", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMM13", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TK1", "TKFC", "TKT", "TLN1", "TLN2", "TMA16", "TMED2", "TMED5", "TMED7", "TMEM14C", "TMLHE", "TMOD3", "TMPO", "TMPO", "TMPPE", "TMTC3", "TMX1", "TMX2", "TMX4", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1A", "TOR1AIP1", "TOR1AIP2", "TOR1B", "TP53", "TP53BP1", "TPBG", "TPD52L2", "TPI1", "TPM4", "TPP1", "TPP2", "TPT1", "TRA2A", "TRA2B", "TRAP1", "TRAPPC2L", "TRAPPC3", "TRAPPC5", "TRAPPC8", "TRIM13", "TRIM21", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIO", "TRIP10", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSC2", "TSFM", "TSG101", "TSNAX", "TSPAN3", "TSPAN6", "TSPO", "TSPYL1", "TTC1", "TTC19", "TTC26", "TTC37", "TTC38", "TTC4", "TTC7B", "TTF2", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBG1", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TWNK", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNL4A", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAC1", "UBAP2", "UBAP2L", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBL5", "UBLCP1", "UBP1", "UBQLN2", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP28", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIRMA", "VKORC1L1", "VPS16", "VPS25", "VPS26A", "VPS26B", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WARS2", "WDR1", "WDR12", "WDR18", "WDR26", "WDR3", "WDR36", "WDR4", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR7", "WDR70", "WDR73", "WDR74", "WDR75", "WDR76", "WDR77", "WDR82", "WFS1", "WIPI2", "WIZ", "WRAP53", "XAB2", "XPA", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "YARS", "YARS2", "YBX1", "YBX3", "YKT6", "YLPM1", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3H7B", "ZC3HAV1", "ZCCHC3", "ZFR", "ZFYVE16", "ZNF281", "ZNF512", "ZNF512B", "ZNF638", "ZPR1", "ZZZ3"], "leading_proteins": ["ABCB7", "ABHD10", "ACBD3", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ADD1", "ADI1", "AFG3L2", "AGPS", "AHSA1", "AIFM1", "ALDH3A2", "ANKLE2", "ANKRD13A", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "ARCN1", "ARFGAP1", "ARFIP1", "ARHGEF7", "ARID4B", "ASCC1", "ATP13A1", "ATP1A1", "ATP1B1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP7A", "ATP7B", "BAIAP2", "BSG", "CALU", "CASK", "CD276", "CD47", "CETN2", "CNNM4", "COPZ1", "COX15", "CPT2", "CPVL", "CRK", "CTSA", "CXADR", "CYB5B", "CYP20A1", "DAG1", "DLD", "DNA2", "DNAJA2", "DNAJA3", "DNAJC1", "DNAJC16", "DNAJC3", "DOCK1", "EHD1", "EHD4", "EMD", "EPHA7", "EPHX1", "ERAP1", "ERLIN1", "ERLIN2", "ETFDH", "FARP2", "FKBP14", "FLOT1", "FNBP1", "FOXRED1", "FUCA1", "FUCA2", "FUS", "GAA", "GALNT1", "GAPVD1", "GBA", "GGCX", "GGPS1", "GLA", "GLB1", "GNA13", "GNAI1", "GNAI2", "GNAO1", "GUSB", "HEXA", "HLA-A", "HLA-C", "HMOX2", "HSDL2", "HSP90AA1", "HSP90B1", "HTRA2", "ILVBL", "KDM1B", "KDM5A", "KIAA0319L", "L2HGDH", "LASP1", "LDAH", "LEMD3", "LETM1", "LIPA", "LMNB1", "LMNB2", "LNPEP", "LPCAT1", "LSS", "M6PR", "MACF1", "MAN2A1", "MAPRE2", "MCL1", "MGST2", "MIA2", "MIA3", "MICU1", "MICU2", "MIPEP", "MOSPD2", "MPP1", "MPP2", "MPP6", "MRC2", "MTCH1", "MTCH2", "MTR", "NAF1", "NAGLU", "NAP1L4", "NENF", "NLN", "NNT", "NPEPPS", "NT5C3B", "NUCB1", "NUCB2", "OCLN", "PAK4", "PARL", "PCYOX1", "PDE6D", "PDK1", "PDK3", "PEF1", "PFDN2", "PFDN6", "PHB", "PHB2", "PIGG", "PIK3R2", "PLA2G15", "PLXNB2", "PMPCA", "PNPLA6", "POR", "PPT1", "PPT2", "PRCP", "PRPF40A", "PSMB5", "PSME2", "PSME3", "PTPRF", "RASA1", "RBM10", "RBM5", "RCN1", "RCN2", "REPS1", "RETSAT", "SCP2", "SCPEP1", "SDCBP", "SDF4", "SDHB", "SEC22B", "SEC63", "SEL1L", "SET", "SGPL1", "SH3GLB1", "SLC19A1", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC2A8", "SNX2", "SNX5", "SPART", "SQLE", "SQSTM1", "SRPRA", "STAM", "STOML2", "STX10", "STX4", "STX5", "STX6", "STX7", "SYNJ2BP", "TAF15", "TEX264", "TIMM50", "TMED2", "TMED7", "TMPO", "TOR1AIP1", "TRAP1", "TRAPPC5", "TRIO", "TSPAN3", "TUBB", "TUBB2A", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "UBP1", "UQCRC2", "UTRN", "VAMP7", "VDAC1", "VDAC3", "VPS26B", "VPS4B", "YKT6", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAZ", "ZCCHC3"]} \ No newline at end of file diff --git a/interpro_ptm/advanced/idx2term.json b/interpro_ptm/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6b2b1d3e31851c6905a093a9239a9bf9fdb4ccf5 --- /dev/null +++ b/interpro_ptm/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "P-type ATPase, phosphorylation site [IPR018303]"} \ No newline at end of file diff --git a/interpro_ptm/advanced/plot_0.png b/interpro_ptm/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..1eaaa0f6a647acb519cf4cb66cfd3eb8c1fe96b0 --- /dev/null +++ b/interpro_ptm/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:8ab9bbd0925fb865b4562046fb71551aa19546c972b92008e1950f8d584be530 +size 161943 diff --git a/interpro_ptm/basic/idx2term.json b/interpro_ptm/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6b2b1d3e31851c6905a093a9239a9bf9fdb4ccf5 --- /dev/null +++ b/interpro_ptm/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "P-type ATPase, phosphorylation site [IPR018303]"} \ No newline at end of file diff --git a/interpro_ptm/basic/plot_0.png b/interpro_ptm/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..59695dc16d82a72db251c9896cf9753fb5663a47 --- /dev/null +++ b/interpro_ptm/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:cc58d504706e6d4608b1df1bbc402437367007fff41e3b3b9d7510b3d7fa9636 +size 142043 diff --git a/interpro_ptm/consensus.joblib b/interpro_ptm/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..328ff8d767ab3bb92c65776b4f917c8db612e6a8 --- /dev/null +++ b/interpro_ptm/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:d47d4243bc1ce785a2fa71b549fc925a1fae3e1430ad0ac374ec4d9f83e9d390 +size 69356 diff --git a/interpro_ptm/df_merge.tsv b/interpro_ptm/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..9ad23106507c750f7309806247e0a89ce425c442 --- /dev/null +++ b/interpro_ptm/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +P-type ATPase, phosphorylation site [IPR018303] 7 8 2.7360476652840746 0.0062182018272194 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 1.387816695443604e-05 1.0 1.0 0.0152248647419399 5.100313122590283e-06 diff --git a/interpro_ptm/metrics.json b/interpro_ptm/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..9ae8063041931439e10fce1ac0e86b9f7193a8a4 --- /dev/null +++ b/interpro_ptm/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3120, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 2.75 +} \ No newline at end of file diff --git a/interpro_ptm/paths.json b/interpro_ptm/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..0cbaf5f17a05a21a5864f636a1cc5b5fb5cf7323 --- /dev/null +++ b/interpro_ptm/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_ptm/fragment/C390/C390_val_log2fc"} \ No newline at end of file diff --git a/interpro_ptm/result.tsv b/interpro_ptm/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..a5fce584e38644ef89c54e64711791c3455ef557 --- /dev/null +++ b/interpro_ptm/result.tsv @@ -0,0 +1,2 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +P-type ATPase, phosphorylation site [IPR018303] 0.8631105398457536 2.7360476652840746 0.0062182018272194 0.0246417713428435 0.0248728073088777 8 P16615,P98194,P20020,P05023,Q04656,Q9HD20,P35670 7 diff --git a/interpro_ptm/selections.json b/interpro_ptm/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..e85d5a3a5913910981b62cc7b4b6eeff45bb6764 --- /dev/null +++ b/interpro_ptm/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["EGF-type aspartate/asparagine hydroxylation site [IPR000152]", "P-type ATPase, phosphorylation site [IPR018303]", "Phosphopantetheine attachment site [IPR006162]", "Translation elongation factor, IF5A, hypusine site [IPR019769]"], "available_proteins": ["ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP7A", "ATP7B", "EIF5A", "FASN", "SLIT2"], "leading_proteins": ["ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2C1", "ATP7A", "ATP7B"]} \ No newline at end of file diff --git a/interpro_repeat/advanced/idx2term.json b/interpro_repeat/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6dce773863970e13dd9ed6c0019ab4c4e97de280 --- /dev/null +++ b/interpro_repeat/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Mitochondrial substrate/solute carrier [IPR018108]"} \ No newline at end of file diff --git a/interpro_repeat/advanced/plot_0.png b/interpro_repeat/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..e0c42d20f71739033026562eb171e5b6a99d28d1 --- /dev/null +++ b/interpro_repeat/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:23f5808ec1afea1f2a1c993e3f43a3e3ecfcd2921ee74e78810eaca5dbed6f3e +size 183780 diff --git a/interpro_repeat/basic/idx2term.json b/interpro_repeat/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6dce773863970e13dd9ed6c0019ab4c4e97de280 --- /dev/null +++ b/interpro_repeat/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Mitochondrial substrate/solute carrier [IPR018108]"} \ No newline at end of file diff --git a/interpro_repeat/basic/plot_0.png b/interpro_repeat/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..11d4364ad1653e34218f5f18317b3f73b8da137c --- /dev/null +++ b/interpro_repeat/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:4bcb3fc5c1339c253d0c7bf52c7076494d1969f0f19b05c758be0cb7f42a8ef3 +size 148568 diff --git a/interpro_repeat/consensus.joblib b/interpro_repeat/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..b5c9cfe2e3159925a00525d5c242260a307f4eca --- /dev/null +++ b/interpro_repeat/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:525b36cabe02329029355a795676099ba108ac2b5361d6497a296b11e0565be6 +size 76181 diff --git a/interpro_repeat/df_merge.tsv b/interpro_repeat/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..b9a59e7b08fa547b04a8156228de07085c8e4454 --- /dev/null +++ b/interpro_repeat/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Mitochondrial substrate/solute carrier [IPR018108] 16 19 3.202275118127538 0.0013634671142808 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 1.3618089061616092e-06 0.1644315705571846 0.0513963234576887 0.002055769463525 1.1521546305420906e-06 diff --git a/interpro_repeat/metrics.json b/interpro_repeat/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..598235056cbd8fb41753160daa14b5b4b10da55a --- /dev/null +++ b/interpro_repeat/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3120, + "annotations_size": 81, + "title": "Average number of proteins per term", + "value": 5.074074074074074 +} \ No newline at end of file diff --git a/interpro_repeat/paths.json b/interpro_repeat/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..fe1c39eec34c16044afcbdfca79ac19b48ed1fdb --- /dev/null +++ b/interpro_repeat/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_repeat/fragment/C390/C390_val_log2fc"} \ No newline at end of file diff --git a/interpro_repeat/result.tsv b/interpro_repeat/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..93c3eb6dbd3737aaefec2fc7491dca9386d4ccff --- /dev/null +++ b/interpro_repeat/result.tsv @@ -0,0 +1,4 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Mitochondrial substrate/solute carrier [IPR018108] 0.7329135042392056 3.202275118127538 0.0013634671142808 0.1046281713602653 0.110440836256746 19 P12236,Q9H936,O43772,Q6NUK1,P12235,Q9Y6C9,Q70HW3,O75746,Q9BQT8,Q9H2D1,Q9HC21,Q9UBX3,Q9UJS0,O43808,P05141,Q9NZJ7 16 +Sel1-like repeat [IPR006597] 0.7938662189010136 1.0317363042353993 0.3021956653786688 0.99999999999978 0.597020704772492 3 Q9UBV2 1 +Tetratricopeptide repeat 2 [IPR013105] 0.4677574590952916 0.0756748547435929 0.9396777816228736 1.0 0.9884922118370488 3 Q14318,Q02790 2 diff --git a/interpro_repeat/selections.json b/interpro_repeat/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..685d63081761b050ffc99581412028531ba14c11 --- /dev/null +++ b/interpro_repeat/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Adenomatous polyposis coli (APC) repeat [IPR041257]", "Adenomatous polyposis coli protein repeat [IPR009223]", "Adenomatous polyposis coli protein, 15 residue repeat [IPR009240]", "Ankyrin repeat [IPR002110]", "Annexin repeat [IPR018502]", "Armadillo [IPR000225]", "Atypical Arm repeat [IPR032413]", "BIR repeat [IPR001370]", "BspA type Leucine rich repeat region [IPR026906]", "Calponin repeat [IPR000557]", "Cation-independent mannose-6-phosphate receptor repeat [IPR000479]", "Chromosome region maintenance repeat [IPR041123]", "Clathrin, heavy chain, propeller repeat [IPR022365]", "Clathrin, heavy chain/VPS, 7-fold repeat [IPR000547]", "Collagen triple helix repeat [IPR008160]", "Cysteine-rich Golgi apparatus protein 1 repeat [IPR001893]", "Cysteine-rich Golgi apparatus protein 1 repeat, eukaryote [IPR017873]", "Exportin-1, repeat 2 [IPR041235]", "Exportin-1, repeat 3 [IPR040485]", "FG-GAP repeat [IPR013517]", "Filamin/ABP280 repeat [IPR001298]", "Filamin/ABP280 repeat-like [IPR017868]", "G-protein beta WD-40 repeat [IPR020472]", "GTF2I-like repeat [IPR004212]", "HAT (Half-A-TPR) repeat [IPR003107]", "HEAT repeat [IPR000357]", "HEAT repeat associated with sister chromatid cohesion protein [IPR026003]", "HEAT, type 2 [IPR021133]", "HUWE1/Rev1, ubiquitin binding region [IPR025527]", "Hexapeptide repeat [IPR001451]", "Hs1/Cortactin [IPR003134]", "Huntingtin, middle-repeat [IPR024613]", "Importin repeat 4 [IPR041653]", "Importin repeat 6 [IPR041389]", "Importin repeat [IPR040928]", "Integrin alpha beta-propellor [IPR013519]", "KI67R [IPR012568]", "Kelch repeat type 1 [IPR006652]", "Kelch repeat type 2 [IPR011498]", "Kinesin light chain repeat [IPR015792]", "Leucine rich repeat 4 [IPR025875]", "Leucine-rich repeat [IPR001611]", "Leucine-rich repeat, cysteine-containing subtype [IPR006553]", "Leucine-rich repeat, typical subtype [IPR003591]", "Low-density lipoprotein (LDL) receptor class A repeat [IPR002172]", "Mbt repeat [IPR004092]", "Microtubule associated protein, tubulin-binding repeat [IPR001084]", "Mitochondrial substrate/solute carrier [IPR018108]", "NHL repeat [IPR001258]", "Nebulin repeat [IPR000900]", "Neuraxin/MAP1B repeat [IPR000102]", "P120R repeat [IPR012586]", "PBS lyase HEAT-like repeat [IPR004155]", "PFTB repeat [IPR001330]", "Paired amphipathic helix [IPR003822]", "Parallel beta-helix repeat [IPR006626]", "Pentatricopeptide repeat [IPR002885]", "Plectin repeat [IPR001101]", "Plexin repeat [IPR002165]", "Proteasome/cyclosome repeat [IPR002015]", "Protein of unknown function DM15 [IPR006607]", "Protein prenyltransferase, alpha subunit [IPR002088]", "Proteinase inhibitor I27, calpastatin [IPR001259]", "Pumilio RNA-binding repeat [IPR001313]", "Putative TPR-like repeat [IPR031545]", "Pyrrolo-quinoline quinone repeat [IPR002372]", "RNA helicase p68 repeat [IPR012587]", "RNA polymerase II, heptapeptide repeat, eukaryotic [IPR000684]", "Regulator of chromosome condensation, RCC1 [IPR000408]", "Ribonuclease inhibitor, leucine rich repeat cap [IPR041302]", "SAMP [IPR009224]", "Sel1-like repeat [IPR006597]", "Spectrin repeat [IPR002017]", "Spectrin/alpha-actinin [IPR018159]", "Tetratricopeptide repeat 1 [IPR001440]", "Tetratricopeptide repeat 2 [IPR013105]", "Tetratricopeptide repeat [IPR019734]", "Vesicle tethering protein p115, armadillo tether-repeat [IPR041209]", "WD40 repeat [IPR001680]", "Wolframin, Sel1-like repeat [IPR045458]", "Zinc finger, C2H2C-type [IPR002515]"], "available_proteins": ["AAAS", "AAMP", "ACTN1", "ACTN4", "AIP", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKRD13A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP2B1", "APC", "ARMC1", "ARMC6", "ARMCX3", "ARPC1A", "ARPC1B", "ASPH", "BIRC6", "BOP1", "BRAT1", "BUB3", "CAST", "CDC23", "CDC27", "CHAF1B", "CKAP5", "CLPB", "CLTC", "CNN2", "CNN3", "COA7", "COLEC12", "COPA", "COPB2", "CORO1C", "CRNKL1", "CSTF1", "CSTF3", "CTNNB1", "CTNND1", "CTR9", "CTTN", "DCAF13", "DCAF7", "DDX5", "DNAAF5", "DNAJC3", "DNAJC7", "DOHH", "DSP", "DST", "EDC4", "EED", "EHMT1", "EHMT2", "EIF2B5", "EIF3I", "ELP2", "EMC1", "EMC2", "EML4", "EPPK1", "FKBP4", "FKBP5", "FKBP8", "FLII", "FLNA", "FLNB", "FLNC", "FNTA", "FNTB", "GCN1", "GEMIN5", "GLG1", "GLS", "GMPPA", "GRWD1", "GTF2I", "GTF3C2", "GTF3C3", "HCFC1", "HECTD1", "HTT", "HUWE1", "IFT88", "IGF2R", "IPO4", "IPO5", "ITGAV", "JUP", "KAT7", "KDELC2", "KDM2A", "KIAA1468", "KLC1", "KLC4", "KLHDC4", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "LARP1", "LASP1", "LLGL1", "LRBA", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC57", "LRRC59", "LRRC8C", "LRWD1", "MACF1", "MAP1B", "MAP4", "MED16", "MKI67", "MRPS27", "MTCH1", "MTCH2", "MTPN", "MYCBP2", "NAA15", "NASP", "NEK9", "NHLRC2", "NIPBL", "NISCH", "NLE1", "NOL10", "NOP2", "NOP9", "NPHP3", "NUP214", "NUP37", "NUP43", "NXF1", "OGT", "P4HA1", "PAFAH1B1", "PAK1IP1", "PDCD11", "PHIP", "PLAA", "PLEC", "PLRG1", "PLXNB2", "POLR2A", "PPID", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP4R1", "PPP5C", "PREB", "PRKCSH", "PRMT9", "PRPF19", "PRPF4", "PRPF6", "PSMD1", "PSMD10", "PSMD2", "PTCD1", "PTCD3", "PUM1", "PUM3", "PWP1", "PWP2", "RABGGTA", "RACK1", "RAE1", "RAI14", "RANBP2", "RANGAP1", "RAP1GDS1", "RBBP5", "RCC1", "RCC2", "RNH1", "RPAP3", "RRP9", "RSU1", "SART3", "SCAP", "SCML2", "SCRIB", "SEC13", "SEC31A", "SEH1L", "SEL1L", "SGTA", "SHCBP1", "SHOC2", "SIN3A", "SIN3B", "SKP2", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLIT2", "SMU1", "SNRNP40", "SNRPA1", "SPTAN1", "SPTBN1", "SPTBN2", "SRP72", "STIP1", "STRAP", "STRN", "STUB1", "SUGT1", "SYNE1", "SYNE2", "TAGLN2", "TBL2", "TBL3", "TEX10", "THOC3", "THOC6", "TMTC3", "TOMM34", "TOMM70", "TPBG", "TRIO", "TTC1", "TTC19", "TTC26", "TTC37", "TTC4", "TTC7B", "UNC45A", "USO1", "UTP15", "UTP18", "UTP4", "UTP6", "UTRN", "VPS18", "WDR1", "WDR12", "WDR18", "WDR26", "WDR3", "WDR36", "WDR4", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR7", "WDR70", "WDR73", "WDR74", "WDR75", "WDR76", "WDR77", "WDR82", "WFS1", "WIPI2", "WRAP53", "XAB2", "XPO1", "ZC3H7B"], "leading_proteins": ["FKBP4", "FKBP8", "MTCH1", "MTCH2", "SEL1L", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6"]} \ No newline at end of file diff --git a/msigdb_gobp/advanced/idx2term.json b/msigdb_gobp/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9830deaf51a72ed9189b598992b271b700c2e2e6 --- /dev/null +++ b/msigdb_gobp/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Anion transport", "1": "Mitochondrial transmembrane transport", "2": "Anion transmembrane transport", "3": "Mitochondrial transport", "4": "Membrane lipid metabolic process", "5": "Protein localization to mitochondrion", "6": 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0000000000000000000000000000000000000000..31f40aeba40a91d5e6ee63b352698fd194edf67a --- /dev/null +++ b/msigdb_gobp/df_merge.tsv @@ -0,0 +1,216 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Anion transport 46 70 4.243047985714493 2.2050426251141172e-05 26.953883495145632 69.53155339805825 1.854216838065017 0.2425457725148559 12.138973160217668 8.434296289414672 2.014686633079497 0.3448588040224388 3.4711311133895884e-06 0.0003264881681153 0.0006627325516806 0.0003424829441338 1.2533897888423431e-05 +Mitochondrial transmembrane transport 35 49 4.223888258014254 2.401231397808345e-05 19.070388349514563 50.63834951456311 1.9310146760091371 0.188342667216329 9.760351579527285 3.939196260509299 1.9786128158557912 0.3017981993827387 4.883483689500796e-10 4.620057885845172e-05 1.6342529313586228e-05 3.55842041397339e-05 7.618601004410258e-12 +Anion transmembrane transport 34 41 4.19903356319418 2.680565904933374e-05 18.02912621359223 42.29854368932039 1.9137296804814252 0.1915609440243116 8.771596162415214 5.032004157423188 1.8922368499585025 0.2935375719655638 0.0001174101190831 0.0001718447263906 9.714238185978128e-05 0.0015161779380161 0.0003214671808756 +Mitochondrial transport 38 83 4.117587469597863 3.8285923580128056e-05 26.76456310679612 83.42233009708738 1.9353944346565397 0.260698067067068 11.29934298946582 6.8259418360610375 1.9296757414965091 0.3685496297416806 6.903298991981865e-14 0.0001307993031292 6.034652924825416e-07 6.378827315920776e-07 4.7525094268716e-15 +Membrane lipid metabolic process 20 36 4.059811677418075 4.911231092274981e-05 15.813106796116504 37.71116504854369 1.423850539998867 0.1808469841706369 6.252884620395072 4.742042041181393 2.289538519382486 0.2724480316274368 1.888413003247048e-07 0.109317488334835 0.028278569718715 1.7678621856310766e-07 2.6596484244335136e-07 +Protein localization to mitochondrion 27 60 3.946924389578105 7.916154260190211e-05 18.37621359223301 58.6747572815534 1.743973973786015 0.2835887708870952 7.329731795051445 5.553888141183353 1.6030721833013164 0.3628376459321563 9.218656570163079e-10 0.0141530490628759 0.0005873272870129 5.6497138129392335e-05 3.938101222010811e-11 +Mitochondrial respiratory chain complex assembly 18 40 3.890989788192895 9.98361350619259e-05 14.427184466019416 38.300970873786405 1.6683402305651691 0.229838901803248 5.648441561419256 5.588363345618 1.6629328950455762 0.3088219725228932 1.6768465818465615e-09 0.0682233334158436 0.0002332117630992 2.46487561955855e-07 9.480959994040974e-09 +Mitochondrial membrane organization 25 44 3.78155002117849 0.0001558548962798 16.983009708737864 46.91019417475728 1.283632855732258 0.3380738792929293 7.413069190635445 4.027718639381892 1.6948461264793506 0.367302285357348 2.7153545877621497e-08 0.0748672511654648 0.0135945544498884 4.6621634009032395e-07 7.317389282109348e-10 +Sphingolipid metabolic process 15 27 3.738365106118082 0.0001852208294428 12.631067961165048 29.174757281553397 1.3566630100256978 0.1614907042591146 4.986857078326301 3.461093559903884 2.232073980338918 0.2503191978902473 3.363168741635684e-06 0.0721850613161859 0.061711249787699 1.5216723372235428e-05 1.0242384721834147e-05 +Organic anion transport 31 47 3.70729044324294 0.0002094886377843 18.575242718446603 46.57281553398058 1.6158560948583975 0.2692356013040078 9.46386426798458 5.9518324529926545 1.7470285445738305 0.3371920110610632 0.0042871150666001 0.4955746593898518 0.1608702453512187 0.0232625208838642 0.0101510925435695 +Organic acid transmembrane transport 22 30 3.668097562794492 0.0002443619448366 12.37621359223301 29.983009708737864 1.9038035525846064 0.1759244630123113 6.520447095353999 3.550222565141749 1.416714921004232 0.2641413901650407 0.001091562086318 0.3154415256826839 0.0415809882988902 0.0126135475433129 0.0015858816854951 +Inner mitochondrial membrane organization 16 21 3.614652920175154 0.0003007502579539 9.985436893203884 20.800970873786408 1.138268089020681 0.2873707765098114 4.6289277788641146 2.4012939531921327 1.609232985153232 0.3229583948801056 6.496171838891283e-10 1.0 0.3009165941166509 1.6510644959116593e-07 5.547005144081462e-11 +Protein targeting to mitochondrion 23 48 3.579465971109962 0.0003442970760358 14.980582524271844 46.067961165048544 1.7767024064550243 0.249920045184344 6.494927942714517 4.708517660750424 1.5433015545903224 0.3384144763122346 4.1776552785312416e-08 0.008121261283644 0.0015449109291633 0.0012481596775334 8.068301246082364e-10 +Glycoprotein metabolic process 20 58 3.3948452460680443 0.0006866740232189 18.59223300970874 59.577669902912625 0.8707431654759812 0.409720724299967 7.543964208858723 9.989377193127202 1.488085349392555 0.3835029669336279 0.001434807783217 0.6598712392014866 0.1725838712124082 0.003278514197237 0.0032371410837193 +Membrane lipid biosynthetic process 11 22 3.347160145416039 0.0008164402950321 8.866504854368932 23.050970873786408 1.3229385051208649 0.2431293012321725 4.229937732502716 3.4850337476777224 1.635527795490498 0.2996124846932806 0.0013231080936128 0.3219228357858488 0.1862598674919939 0.0035695402472551 0.0005580518501476 +Proton transmembrane transport 14 46 3.3405334370083333 0.0008361761116042 14.28640776699029 43.01699029126213 0.7821394801431882 0.3918912894345224 6.076814900000799 3.1076483585332 1.5710697941383835 0.3739424994204808 3.363168741635684e-06 0.000966616101208 3.158896646363367e-05 2.463765146783068e-06 1.0242384721834147e-05 +Ceramide metabolic process 9 17 3.314460358823578 0.0009182019820059 8.191747572815533 19.060679611650485 1.0632949889077032 0.1865092544415649 3.2982239784478966 2.5917545738626013 1.8901201919357584 0.2494992632187684 6.384973781123121e-05 0.236404668572991 0.1039407380726692 0.0004129808075874 0.0003655904724143 +Oxidative phosphorylation 19 64 3.307108516402709 0.0009426436777244 18.140776699029125 60.61893203883495 0.8137621380364766 0.3661293054253088 7.750013302753429 5.582386553809936 1.7413544544034578 0.3762713520958283 3.1925743908811816e-08 1.8317171140167018e-05 1.8920581249478457e-07 5.514070101096918e-06 2.2960543316699705e-07 +Organophosphate ester transport 15 26 3.297022274986638 0.0009771575116197 10.29126213592233 27.364077669902912 1.4948680330369015 0.1889391065154625 4.84293313185659 4.31957284765524 1.6451867819665518 0.2532208690981375 0.000988883953264 0.0531691841805127 0.175896893635733 0.0028924350901622 0.0047064147832106 +Endoplasmic reticulum organization 24 46 3.287126227800677 0.0010121545357693 14.91747572815534 43.67718446601942 1.1418424810127707 0.3725584991544436 6.208589840117394 4.768440325801463 1.6823827875834556 0.3705219831566139 1.2149046059405925e-06 0.0496186824069471 0.0060698672163979 8.331817056305445e-05 9.382205426599828e-08 +Glycoprotein biosynthetic process 18 51 3.265562835832312 0.0010924676422123 16.72087378640777 51.87378640776699 1.042113998842759 0.381483262234126 6.756316800759528 8.908847583990125 1.5232206853916193 0.3819786061588057 0.0012862064563682 0.5954641326339 0.275702193658781 0.0021759005991081 0.0021991781612957 +Protein transmembrane transport 14 24 3.2479821556942547 0.0011622655945404 8.992718446601941 25.191747572815533 1.6893060623430327 0.189108476986505 4.473486660459625 2.7693940759543416 1.4682653164365471 0.2783169275392022 3.3167149218296684e-05 0.0019447965050573 0.0016384890204764 0.0016490180911792 1.0029805990324731e-06 +Liposaccharide metabolic process 10 17 3.2395410612448745 0.0011972222711393 7.393203883495145 16.839805825242717 0.7162233803449398 0.1804705798886219 2.8837934205508033 2.921890590438037 1.8930166841377585 0.2403675114219934 1.2737294033781711e-05 1.0 0.107004894081217 9.084488218482784e-06 1.7329168891142377e-05 +Organic acid transport 25 44 3.2344849177323898 0.0012186235678988 16.199029126213592 46.1626213592233 1.6912598339530378 0.23494744574913 7.685833584742487 5.405881453891157 1.4084922190667013 0.315570201131532 0.0187968790127338 0.4783938870567416 0.1449031461986719 0.1138666570015389 0.0342361314750581 +Glycerolipid metabolic process 20 63 3.2286197307141085 0.0012438917661257 16.934466019417474 64.79854368932038 -0.000323163470851 0.4552448147740581 9.046432352430308 10.372466251166422 1.3758971299503038 0.353332456533291 0.0081664634013294 0.3229860752418801 0.211584805129799 0.0025475550559014 0.0084959528742768 +Aminoglycan metabolic process 11 16 3.144267493011702 0.001665031653776 6.650485436893204 15.218446601941748 0.5538240398360251 0.1973407167351751 2.4739761552565955 2.4752855115427597 1.8355272359461776 0.2521795038965069 4.1103559978505625e-06 0.2543128795765555 0.0029226642017144 0.0001124126246146 3.5162408817055444e-05 +Lytic vacuole organization 13 24 3.1353092567866776 0.0017167302890439 8.677184466019417 23.79368932038835 1.067589638534915 0.1668002350701783 2.8744208086829883 3.077266940940983 2.0111064761459874 0.2496786569477077 0.0001003682249153 0.0001737607377435 0.0002661164710619 0.0031264397563519 0.0001244263791846 +Carboxylic acid transport 19 32 3.112485954475102 0.0018551884144271 12.351941747572816 33.69417475728155 1.517249458545343 0.2522623764771551 6.23371050940395 4.11174791553619 1.419876490432768 0.3135855212793009 0.1181923690380001 0.3922727602504912 0.0801526286479979 0.2477744336730244 0.1374763991753785 +Nadh dehydrogenase complex assembly 10 28 3.053637214812947 0.0022608530313537 9.266990291262136 26.96359223300971 1.1245271541492263 0.3013677937017552 4.122702675359976 4.029157649894909 1.4460543016521823 0.3224564676521605 1.0692586569304517e-05 1.0 0.0021465314893355 7.83778432534745e-06 1.4366492032750328e-05 +Glycerolipid biosynthetic process 17 42 3.0422614124965004 0.0023480787836616 13.466019417475728 44.71844660194175 0.9430872689732808 0.3767257192898063 6.88753698417372 8.249645447783736 1.3199493331746477 0.3584243730449019 0.0527129946839807 0.577581418089764 0.2522992371519743 0.0312738129317772 0.030091919054275 +Carbohydrate derivative transport 12 16 3.03833815564162 0.0023788684758194 7.924757281553398 17.024271844660195 1.3665639952580566 0.1869571280171947 4.210097511648942 2.624454303682939 1.5541767319140831 0.2467993156006303 0.0003681818874055 1.0 1.0 0.0048028453089964 0.0014891058006406 +Tetrapyrrole metabolic process 7 19 3.028164220522167 0.0024604434053308 5.652912621359223 19.283980582524272 1.0342508202848784 0.290677507336007 2.6828141040028877 2.549402305664568 1.2308389507353266 0.2976223887279709 0.001480117718684 0.1878492321971458 0.0666692325567911 0.0006073886965184 0.00110124435718 +Cytochrome complex assembly 8 12 2.9845071599485773 0.0028403555385372 5.339805825242719 11.616504854368932 1.5489281771301031 0.1834582376033618 2.45860248431673 2.439266047793512 1.3189185418401956 0.2620853228235733 3.869022304188862e-05 0.0110614955842043 0.0041517217414646 0.0001415457384854 0.0001729005795719 +Organelle fusion 30 52 2.977149857718305 0.0029094176131418 14.74514563106796 45.383495145631066 0.6448767361523368 0.5292766623385164 6.293825046556003 6.576179389035289 1.1045479661060835 0.3741954647136961 0.0006014988475365 1.0 0.3068592732118059 0.0069434839747996 1.1075910406921447e-05 +Steroid metabolic process 20 63 2.973789209305864 0.002941470654878 17.82766990291262 66.9247572815534 0.9974586731388552 0.3270410156332073 6.090491666967852 5.93996409793671 1.7133199907504504 0.3720334828404655 3.846216468044711e-05 0.5237470911105582 0.7809139112323245 0.0044922754835291 2.0159575807295905e-05 +Vacuole organization 22 55 2.967741574853195 0.0029999643831937 14.220873786407768 51.74514563106796 0.8524122478550634 0.3147425083910056 5.370022076358251 7.439112114793103 1.7567175511320523 0.3563110134355993 0.0011139493878373 0.0059476608388677 0.016676938082001 0.0812926464798529 0.0034833061200819 +Respiratory electron transport chain 17 53 2.960627415199649 0.0030701309963165 15.4126213592233 50.33495145631068 0.497076868891423 0.4388579749555677 7.129498131980449 4.223655269147207 1.4894225458303931 0.3736358875877055 1.5910754051392514e-07 0.0103010078837755 0.0003120858048586 0.0001017171643149 6.646895390280867e-07 +Porphyrin containing compound metabolic process 7 17 2.955810852643165 0.003118482712086 4.91747572815534 16.531553398058254 1.0269348271542438 0.279733852070357 2.276512713100022 2.089380108414912 1.2578863722796805 0.2914421038569487 0.0003518986673133 0.1524760813950871 0.0443091130960601 0.000167417985794 0.0002147363626889 +Glycerophospholipid biosynthetic process 22 38 2.948650727939288 0.0031916445895756 12.407766990291265 39.55339805825243 0.6228968293784067 0.4586227574071144 6.110530292090928 7.803693618041913 1.233194093755117 0.3515784330467275 0.0983370804935312 0.5327909523059658 0.1991829736874783 0.0924553076159201 0.0474554916638875 +Import across plasma membrane 14 21 2.926252999296048 0.0034307181292692 6.601941747572815 18.643203883495147 0.5666543433877399 0.4743790616320767 3.944616106748078 3.664494750162088 1.0498181035479843 0.3397186310535848 0.3484732068534892 1.0 0.5213291194813008 0.5509866648628524 0.3089718606678731 +Atp synthesis coupled electron transport 12 40 2.9250956812058524 0.0034435032814628 11.567961165048544 37.61407766990291 0.6403585631460136 0.4181082416574377 5.189865284224125 3.9859091462453993 1.417482213086961 0.3703097362636519 9.288960262926536e-06 0.0058176934433743 9.934540328048928e-05 0.0005596761316752 8.638985673939192e-05 +Endoplasmic reticulum membrane organization 6 9 2.921837544634471 0.00347972990024 3.5679611650485437 8.12621359223301 0.656874598832497 0.271683145803182 1.813579499342004 1.2879547393790816 1.532817064292788 0.2945772195616556 1.8990817200445957e-07 0.0595353304203936 0.0066572828402184 8.624555272386569e-06 8.104989222609044e-07 +Membrane lipid catabolic process 7 12 2.908717798124464 0.0036291428905401 5.854368932038835 11.361650485436892 0.500872843713425 0.1363587272813367 1.9603237645724247 0.9867004907377388 2.113024793917032 0.2289617793743788 4.3542840651368e-07 0.0039064712270754 0.0008717411361388 5.415752101895563e-06 2.1902966903943494e-06 +Transition metal ion transport 12 17 2.8612352345625505 0.0042199381348642 4.70873786407767 14.08980582524272 0.8861898222657586 0.2678437025860737 2.4756329698054333 2.718007722894407 1.3738160036140448 0.271065502827487 0.0004431152801346 0.0313211948286675 0.1100932826860655 0.0136344588869589 0.0020026076269409 +Intracellular protein transmembrane transport 11 21 2.859707780269696 0.0042403153728105 7.233009708737864 21.9004854368932 1.450039081018812 0.2247265328975946 3.8281123729210935 2.4627910122818513 1.3220665029303609 0.2876555154826584 0.0016947901282419 0.018891152845815 0.0091243340822671 0.0940672040532474 4.558635539447923e-05 +Carbohydrate derivative catabolic process 13 36 2.8517718196809767 0.004347629704136 9.92233009708738 34.20388349514563 -0.0123085756499559 0.2707665028006943 3.843893961107642 3.291233496452993 1.7787241070250257 0.2878972939517332 0.0001422732793325 1.0 0.2997470465879412 0.0062659657814626 0.001208142066949 +Sphingolipid biosynthetic process 7 15 2.8301311892608028 0.0046528921110899 6.543689320388349 16.33252427184466 1.3108583596388097 0.2293036031089034 3.2058099533310203 2.4273143169149307 1.5209865792019848 0.2861850290041513 0.0079740866190119 0.2436179272361805 0.4353012614103685 0.053649406266927 0.0073008402117251 +Mitochondrial electron transport cytochrome c to oxygen 3 7 2.814429640464091 0.0048863872974129 2.6189320388349513 6.021844660194175 0.7576771538928655 0.3133819177040797 1.4641113893518565 0.9306060741204804 1.2097595052740109 0.2966582872605096 0.000898746356534 0.0550816697898294 0.0001778916397324 0.0001405335592956 0.0019884945269669 +Establishment of protein localization to membrane 36 91 2.798822428283012 0.0051289334474131 23.133495145631063 87.3616504854369 1.231448880072231 0.4195243824117992 8.397245527204214 9.510228790351464 1.3947369206386535 0.4065372973031916 4.864244670711285e-06 0.0152406110107504 0.0465553733545724 0.0001226270718245 1.2718308283772226e-08 +Electron transport chain 20 71 2.778075883918444 0.0054681846285873 19.550970873786408 67.77184466019418 0.3712062453977176 0.4872800905659868 8.486701420407794 5.37626783377928 1.3790913022045077 0.3735693075609537 8.64377913930411e-07 0.0240209396081081 0.0016710768585089 0.0003410608957221 1.365754877843873e-06 +Protein insertion into membrane 14 28 2.7773767860395564 0.0054799612666938 9.861650485436892 27.67718446601942 1.4180388387951812 0.2751856944202687 4.426616888970974 3.3195747527036987 1.508549988584809 0.3318307488597651 2.3312975044275344e-05 0.0238997911322505 0.0128487417044244 0.0002044748778434 6.207469725080071e-07 +Monovalent inorganic cation homeostasis 18 30 2.7570553513585563 0.005832447763171 9.014563106796116 27.87378640776699 1.1567920478867002 0.2845186374336156 4.051822262152646 3.607380814764068 1.4117439861533438 0.3149022278800241 0.0075696537653878 0.2922756805728106 0.033011066423499 0.0018365459096632 0.0026289561565188 +Glycosphingolipid metabolic process 6 9 2.747898697566425 0.0059978537239049 4.764563106796117 9.184466019417476 0.4485135251287195 0.1553285492394019 1.7516723087054535 1.7320372023153958 1.93068386398988 0.2217231968869004 0.0002392207483159 1.0 0.2732850813359189 0.0010720436073174 0.0008647189955035 +Cristae formation 9 10 2.7383016996499445 0.0061757391994858 4.740291262135922 8.861650485436893 0.8982766043222677 0.3392698633906088 2.216011442046921 0.6593503673812457 1.2485531022675598 0.3418736408093433 3.670343353409025e-07 1.0 1.0 1.31526437712885e-05 6.767937567779145e-08 +Metal ion homeostasis 44 82 2.7225088365253063 0.0064788300753353 22.37864077669903 79.5 0.7762327689006491 0.4501210966631583 8.485414676383348 8.298876985671072 1.3957415688189287 0.3857448193070677 1.3219862127270274e-05 0.7155846398970147 0.9237281349260584 0.004637972118601 1.1055453002122732e-05 +Glycosyl compound catabolic process 7 10 2.7158867359865844 0.006609852688838 3.216019417475728 9.74271844660194 -0.2866012386822237 0.2471021044870933 1.8641835401772064 0.9067280280460008 1.4904201092322935 0.2120144867281597 2.213453016494993e-06 1.0 0.2070995190727305 0.0002291586350063 1.0761884384293304e-05 +Amino acid transmembrane transport 12 14 2.712489178753096 0.0066779961746343 6.213592233009709 14.228155339805824 0.7890307267204019 0.3318923540291705 3.493823914060917 1.9561661273054285 1.3497309258640615 0.3227865040448734 0.2801383110615368 1.0 0.3655284832956332 0.6835238209809511 0.1928878867570688 +Hormone metabolic process 10 27 2.704012652850014 0.0068507680464049 8.95631067961165 28.65776699029126 1.130508313948193 0.2963365150575847 3.9674689274001818 2.5345884681715156 1.346801337886388 0.3240077568826507 0.0014140418151011 1.0 0.0665208936004256 0.008907043045769 0.0071979901202258 +Nucleotide transport 10 12 2.6955883634302995 0.0070264438482867 6.189320388349515 13.405339805825244 1.3859091987706234 0.2148450774807873 3.399469193898354 2.266957807297256 1.34942986946681 0.2785977875693559 0.0030137793172406 0.1155957163384056 0.2223047329091382 0.0239571113561098 0.0074494564855197 +Inorganic anion transport 14 24 2.6860972810844177 0.0072292037359844 9.900485436893204 25.351941747572816 1.3590123122148194 0.2025490755989976 4.608697956226863 4.352203003870329 1.5972877171217004 0.2769639658120273 0.0003305827131697 0.0002986444088397 0.0005115527825537 0.0062576945030878 0.0004462881853716 +Protein transmembrane import into intracellular organelle 7 12 2.6841138602471823 0.0072722334986352 4.951456310679611 13.45631067961165 1.503963012554726 0.1758225015375162 2.735521961789203 1.4944992929031071 1.2360761671845495 0.245991671368161 0.0057417875723139 0.1321770275159086 0.0334071197556988 0.1627514901813832 0.0027845492980534 +Phospholipid metabolic process 21 74 2.6776869139646693 0.0074132477051034 18.805825242718445 74.80339805825243 -0.0109191555178773 0.4658808189502442 8.677118948764809 11.032066592781655 1.2956045948013235 0.3559409313369701 0.0052917259854324 0.7029173044859447 0.2278501486536902 0.001253479046918 0.0060664533041377 +Regulation of steroid biosynthetic process 6 11 2.675234776805308 0.0074676934171697 3.186893203883495 10.259708737864075 0.6168896095149775 0.3174156062343823 1.783561142158544 1.373475469974866 1.265753415239616 0.2847701277650337 0.0033396331074836 0.1644315705571846 0.3076603852203092 0.2332121755087385 0.0020709532532559 +Glycerophospholipid metabolic process 16 54 2.668756235709042 0.0076132682131213 14.597087378640778 57.060679611650485 -0.0519222534779674 0.4286122989812534 8.002292830543196 9.368077769293231 1.3877870839733877 0.3500560744701435 0.0321646562395351 0.6254430361790769 0.3177879180268566 0.0112695898534881 0.0226961154677728 +Regulation of steroid metabolic process 6 14 2.653320019370038 0.0079704264057109 4.334951456310679 14.769417475728156 0.4748357054552781 0.3599056508632772 2.2294240946396933 1.955260926764874 1.2378399088740557 0.2930403635554361 0.0155719369465381 0.2180755491779121 0.3955810682553247 0.3583320648627024 0.012256850099211 +Endoplasmic reticulum tubular network organization 6 11 2.646980728523209 0.0081213981081327 4.150485436893204 10.555825242718448 0.8961707031484618 0.3171343629503343 2.1669796342432037 1.8339543060404635 1.2935176897309475 0.3199619326088047 0.0036978306683598 1.0 0.0113213926532688 0.0073447144383531 9.937036022358197e-05 +Pigment metabolic process 9 29 2.634501941071961 0.0084260822026347 6.730582524271845 27.429611650485437 0.7330558837492486 0.3938325994367372 3.1680652652278396 2.973572406869117 1.1788232115476622 0.3357800616079686 0.0002575060825946 0.2291240669446297 0.0157478410048603 0.0003302169514715 0.0002701448047215 +Ion transmembrane transport 82 156 2.6274746207635347 0.0086021258390223 47.09466019417476 154.11893203883494 1.555073205784263 0.3634279635891347 19.61122797656 15.97124025754773 1.9676287128633565 0.411597796705808 9.041468976358186e-09 4.178969391986772e-05 6.49370644714716e-06 1.477085145301308e-05 4.6080501842801975e-08 +Glycosylation 19 46 2.6165272901951937 0.0088829263241481 13.33495145631068 45.42718446601942 0.831363055351092 0.4028474919440285 5.5712021107485015 7.578523489860055 1.3433056638769032 0.3649215649501745 0.0112458292433903 1.0 0.4634232241325184 0.0424513056632203 0.012189756294724 +Cellular ion homeostasis 41 92 2.6012700614128934 0.0092879305500794 24.48543689320388 87.34708737864078 0.921352068115914 0.4223079442129951 9.212290310790763 8.933596252465952 1.5207794649628892 0.4002972861975121 3.0048693214527944e-06 0.7290395724580129 0.4904150555504759 0.0025406668575644 3.1457702434637795e-06 +Endoplasmic reticulum to golgi vesicle mediated transport 28 70 2.6009716863728825 0.0092960125955048 17.32766990291262 65.39077669902913 0.808881464821498 0.4942452999677598 7.539018980743236 6.620812461410292 1.284359804176963 0.3933269611423161 4.087360245025145e-05 0.4205819691215787 0.0246695053344801 0.0001004625143446 9.788867531437944e-06 +Er nucleus signaling pathway 9 14 2.600120178844145 0.0093191117863704 4.563106796116505 13.361650485436892 0.3617919622488442 0.4304556920046536 2.3428051517114805 1.3174649068389608 1.1974910326877934 0.3346175168774911 0.0004223105275086 1.0 1.0 0.0106277501006418 4.047721243423012e-05 +Mitochondrial fusion 11 16 2.5969609936991542 0.0094052603989445 5.730582524271845 14.140776699029129 0.9082040747396848 0.3521825448687026 2.97444400458197 2.016819417247653 1.0465735301082626 0.3054031781597867 0.000773774016396 1.0 1.0 0.0319451393300601 5.065093383128868e-05 +Regulation of hormone levels 14 60 2.5860696531611698 0.0097077310855671 15.682038834951456 62.25485436893204 0.7754141622249116 0.4638741971732045 6.630568201753413 6.49574922456989 1.111399769110166 0.3798141702267368 0.023814593547236 0.644780089608989 0.1559477440516821 0.0375167640954456 0.0629022168304733 +Vitamin transport 6 8 2.563227974096673 0.0103703929990568 3.587378640776699 7.597087378640777 1.658661901456128 0.1256251915839625 1.8073839707699664 1.6422194495621811 1.0713624000848283 0.1994200282768667 0.0002588888842734 0.1071891284628969 0.2070995190727305 0.0193169154759243 0.0008083265510004 +Dicarboxylic acid transport 14 18 2.553777866513862 0.0106561215084053 5.718446601941747 16.097087378640776 1.1205667041867788 0.2998586575349944 3.584398436287638 2.226340822602054 1.0973546365412417 0.2986830136605488 0.0233905612806522 0.1801156574188796 0.0614247268920475 0.2691814013824262 0.0150707717640174 +Inorganic ion transmembrane transport 54 115 2.54999711995652 0.0107723808980431 32.300970873786405 111.99514563106796 0.9881513097876132 0.4268253140664947 13.185263141323642 11.586314982845243 1.7161030277526947 0.4113555760685328 3.0071346163523306e-05 0.0010114048757063 0.0004243546979352 0.0006160911554228 5.370874672582162e-05 +Nuclear envelope organization 17 33 2.5471110784472644 0.0108618852884021 8.555825242718447 29.70873786407767 0.3742592988081523 0.5658154731413123 3.620906131367995 3.382223856109787 0.8839532199066901 0.3277754788938732 0.0486707268156107 1.0 0.3896854720293997 0.3495520980441666 6.207469725080071e-07 +Cellular monovalent inorganic cation homeostasis 16 27 2.532368347294952 0.0113294905759764 8.191747572815533 25.12378640776699 1.1978511848260835 0.2636491484517694 3.558748260132903 2.9783551257949803 1.4212259473978417 0.3021468238591936 0.0095406655710695 0.2507644527164699 0.0207328276809773 0.0033989983353886 0.0025367585545309 +Metal ion export 8 11 2.526425607944156 0.0115229789699717 3.779126213592233 8.553398058252426 0.5059205316086877 0.4155863674545267 2.112664358767855 1.499049247815051 1.150738830143596 0.3315496346975708 0.0010955802287966 1.0 1.0 0.4015375820029667 0.0003689915939861 +Glycoside catabolic process 5 6 2.521894678413271 0.0116724650711264 2.995145631067961 5.604368932038835 0.914408298188202 0.1915126053981477 1.4021397407455505 0.554137429771367 1.5051386650706404 0.245673751384095 9.203475043281534e-08 1.0 1.0 0.0007102815399137 3.274702614006158e-07 +Proteoglycan metabolic process 4 7 2.513596995157957 0.0119506910184141 3.0558252427184467 7.347087378640777 0.90943742591388 0.2775323863615319 1.813993622553226 2.3052106999156825 1.19959130355936 0.2714444012698452 0.0256449511882959 0.1839914155878272 0.0080456420559546 0.0195417527514502 0.0558327828623465 +Lipid localization 18 70 2.508565599145219 0.0121222457525238 20.1504854368932 74.27912621359224 1.3966421040883936 0.3001252105784707 7.306180038477171 9.39465098860316 1.572418240819249 0.3627304234720817 0.0011020189422278 0.2792677388815299 0.1632643902509063 0.0009263382354536 0.0053879562286427 +Cation transmembrane transport 58 123 2.5071807763877576 0.0121698452662111 33.43446601941748 118.4004854368932 1.1701058025505957 0.4085228823574113 14.425169362008605 12.553856783980793 1.6663185381795875 0.4066910074955585 1.0570551447629089e-05 0.0078121497822375 0.0030970494494587 0.0017710553457114 2.7974603066690583e-05 +Protein import into mitochondrial matrix 5 8 2.50209373939112 0.0123461230828143 3.3276699029126213 9.03883495145631 1.4677455160780188 0.1396272549365287 1.9612536628062327 0.7162785445212654 1.2893924319512868 0.2212161399323651 0.0191851660395208 0.0683810764565047 0.0088504827764808 0.0495157384890535 0.0048822579474643 +L amino acid transport 10 12 2.50197636349784 0.0123502169927955 5.114077669902913 11.91504854368932 0.7755289387861473 0.3283794523692901 2.998235059113201 1.3256494094845783 1.3058948249973923 0.3189923022900864 0.1472792808974093 1.0 0.2802926639431586 0.5647101544543685 0.0807266025333323 +Cellular hormone metabolic process 6 16 2.5002322113344597 0.0124111924739784 5.441747572815534 17.32766990291262 0.9908884218524354 0.2940959275691314 2.8170777488519256 1.7185203072340225 1.2515909253444888 0.3031653223897966 0.0035351919501872 1.0 0.08610744549237 0.0341229578056568 0.0110551101007063 +Protein processing 15 45 2.486853296478757 0.0128878532407323 12.08252427184466 45.980582524271846 0.9011703887478908 0.3916089016010577 4.43430858840224 4.931040148104543 1.176660792763282 0.3507158233798557 0.0010970283918881 1.0 0.0447466679201601 0.0192628366959366 0.0011276322830495 +Phospholipid transport 4 14 2.485381040766723 0.0129412831575332 4.038834951456311 13.844660194174756 0.8595089147672731 0.22382450694892 1.931709490395295 2.5542930986961077 1.4491821424024287 0.2459407475876757 0.0486707268156107 0.2143583684675494 0.3896854720293997 0.0341229578056568 0.1000707214680032 +Amino acid transport 14 20 2.4851460146747018 0.0129498306485882 7.771844660194175 19.75 0.8410032854505353 0.3449280742441291 4.117377746800764 3.003739578643708 1.287399790463736 0.3206698223659758 0.2858451600680761 1.0 0.4876012483283494 0.8156459393677341 0.2430359635228135 +Respiratory chain complex iv assembly 5 7 2.484535808526337 0.0129720461075877 2.7475728155339807 6.451456310679611 1.036831430168084 0.2562354664331627 1.605321530277248 1.669274831081891 1.262804896468415 0.2848709091577191 0.0003294901345179 0.1114021565620111 0.0237627189197599 0.0002808583984775 0.0010205277760807 +Mucopolysaccharide metabolic process 6 10 2.4815700243704004 0.0130805006796712 3.400485436893204 8.912621359223301 0.5894446998893683 0.2689339883290864 1.6227448151896249 1.7256308603927724 1.433353391777711 0.275728271795533 0.0016947901282419 1.0 0.0091243340822671 0.0043649502990921 0.0055591316089767 +Purine nucleotide transport 8 10 2.473720389180592 0.0133714302734135 4.970873786407767 10.817961165048544 0.961055494000064 0.2880106547862709 2.8308505383502496 1.988649275322177 1.3314072021441097 0.3042395363852717 0.0416226685335461 1.0 1.0 0.0828772873031817 0.0701952648708137 +Establishment of protein localization to mitochondrial membrane 7 15 2.472861294021342 0.0134036154086099 5.572815533980583 16.524271844660195 1.1986544459127668 0.291784793504827 2.8501471321161915 2.5441524813639957 1.2232399066733852 0.3232066755573589 0.0005152852106469 0.1197698958477507 0.0274603336438859 0.0004102788019959 2.855045826118248e-05 +Phospholipid biosynthetic process 20 54 2.4710797085544227 0.0134705790095501 15.191747572815531 54.88834951456311 0.3601791313916425 0.5325104042072244 6.85810624136386 9.315774292776531 1.1122724170508866 0.3517335331311575 0.0418864245921791 0.6031720335202734 0.2861808409488877 0.0454361539679644 0.0266801883294411 +Transmembrane transport 99 208 2.469677779825461 0.0135234802996664 67.45631067961165 211.1359223300971 1.8122664376950308 0.3598356673827246 27.267027885156203 22.354947126810902 2.251277763144546 0.4188333713481413 3.487000635622325e-13 5.847489231884304e-06 2.631697407787137e-06 7.241351583322856e-07 1.970211989090148e-12 +Signal peptide processing 3 5 2.46295179129942 0.0137798442468717 2.0898058252427183 5.155339805825243 0.788498872885968 0.2357910477072221 1.2938213743418876 0.7208043181852656 1.3841109341751536 0.2490116896927748 0.0006182072975801 1.0 0.1008375048293403 0.0276231155809849 0.0013781701696679 +Regulation of lipid biosynthetic process 8 26 2.449848616741249 0.0142916286711589 5.211165048543689 26.83009708737864 -0.4437734844517033 0.3480223204908034 2.903224120378468 2.997615069864524 1.2473712283529377 0.2827476345582833 0.0246605093510235 0.3472525306689195 0.5823300890010559 0.1723284412806655 0.0301802057555386 +Sterol metabolic process 14 37 2.4324307842165256 0.0149978577316578 11.932038834951456 38.44660194174757 1.1656335789111734 0.2523239777622673 4.346099994655023 4.0619669904912925 1.6676089351046874 0.3062687621764124 0.00011079914626 1.0 1.0 0.0043610876134259 1.2307067154074328e-05 +Protein targeting 42 119 2.417990197716773 0.015606497224845 30.48543689320388 111.54126213592232 1.595466660966077 0.3336055854889273 10.683999539888966 11.70327920021055 1.673091584234216 0.3988264387816677 4.624844315868541e-08 0.0062759976095487 0.0028162377069727 0.00037790881714 2.0049954089114708e-11 +Transition metal ion homeostasis 13 27 2.41375510770715 0.0157890705338106 6.640776699029126 24.57281553398058 0.9239194315613378 0.3015424973151205 2.934079531592402 2.8081087224394015 1.2471169312381896 0.2974369333820005 6.055260106371684e-05 0.3154415256826839 0.5396055987962411 0.0031061282245647 0.0004431313439272 +Regulation of cellular ph 11 22 2.410648696206065 0.0159241786147568 6.885922330097087 20.844660194174757 1.215766922704761 0.2375185297794358 2.9319293283093293 2.765976649626597 1.4143296516981956 0.2875299337708636 0.0117944261645624 0.2068720246493716 0.0115248505447769 0.0063027604866002 0.0022658484440293 +Regulation of ph 11 22 2.410648696206065 0.0159241786147568 6.890776699029126 20.859223300970875 1.2151699598837196 0.2373503364294603 2.930458126920059 2.7746402510870145 1.4154672965603718 0.2873526492076106 0.0155719369465381 0.2180755491779121 0.0135419734012732 0.0081044088621321 0.0033296386804888 +Amide transport 6 34 2.405568576839245 0.0161473210393345 9.512135922330096 37.99757281553398 0.8625203235532012 0.4243895840783888 3.9342099663331425 4.541875701235624 0.963016155404646 0.3369249994514658 0.2916964889634525 0.1357968236714454 0.3803883597337516 0.0479558757106163 0.3477189954247736 +L alpha amino acid transmembrane transport 9 11 2.4048184738197147 0.0161805008430455 4.480582524271845 10.533980582524272 0.7590361902351016 0.3223730555033793 2.606398335255894 1.1951807271273862 1.273814103695318 0.3116596719827348 0.1380592378571038 1.0 0.2732850813359189 0.5539124029112868 0.07392944267488 +Tetrapyrrole biosynthetic process 5 13 2.379057571127711 0.0173569649037093 3.978155339805826 12.308252427184469 0.3532525135599431 0.4350645652075638 2.0813570291196224 1.845916473083467 1.0884111669512433 0.3019410049691661 0.0035816188869452 1.0 0.2297987482657219 0.0037492480554313 0.0015706126808535 +Aminoglycan catabolic process 4 5 2.377813868605584 0.0174156143905361 2.6893203883495147 4.728155339805825 0.5164809724591738 0.1764823388548578 1.1619294817897845 0.7656988020633148 1.69808407883546 0.2279588459746903 5.712917963828504e-05 1.0 1.0 0.0025975272437437 0.0001575214550341 +Glycosaminoglycan catabolic process 4 5 2.377813868605584 0.0174156143905361 2.6432038834951457 4.665048543689321 0.5167433573606753 0.1777854895826483 1.1305026922003756 0.6751064263980151 1.6910244329591049 0.2288538535307848 3.443156653082277e-05 1.0 1.0 0.001983278822638 9.569573614901708e-05 +Terpenoid metabolic process 6 18 2.3710055123002167 0.017739766513501 4.992718446601942 17.42233009708738 0.6301104025923489 0.3704291423404849 2.365292196147205 2.02323551503238 1.1104102314092092 0.2862846297230793 0.0009606853021379 0.1762218760282218 0.0588586045542952 0.0028945217060241 0.0032541181407787 +Ceramide catabolic process 4 7 2.370098410210325 0.0177833511845362 3.8592233009708736 6.531553398058253 0.1286784152295923 0.1423502941444668 1.429436503356119 0.7012295128365029 2.0219843992394857 0.2259194528389771 5.712917963828504e-05 0.0550816697898294 0.0056684159955205 0.0025975272437437 0.0001575214550341 +Entry into host 16 31 2.353619120928017 0.0185916499213056 7.968446601941747 31.24514563106796 0.6061616104105989 0.3954837799611526 3.566493820193545 3.4119437173329663 1.31706945612869 0.333413728218646 0.0105616889225123 0.356510309215238 0.5943645192903619 0.1867445382627056 0.0362411651250499 +Oligosaccharide lipid intermediate biosynthetic process 3 5 2.3395745436273043 0.0193057184819396 2.2742718446601944 5.390776699029126 0.4920123476052065 0.3335995467983793 1.5024311055989734 1.8021595402153228 1.3008390374829126 0.2934249582958821 0.0046090980714051 1.0 1.0 0.0688460117016781 0.0097510399506001 +Cellular transition metal ion homeostasis 10 23 2.3328243626557943 0.0196573654576215 5.893203883495145 20.42233009708738 0.9608801516152976 0.3243056832171095 2.800529150274697 2.6932649561537056 1.130076157725316 0.3011842711337114 3.911463799463137e-05 1.0 1.0 0.0046688430045599 0.0002609651056342 +Aerobic respiration 22 90 2.327372588767349 0.0199454433773809 23.075242718446603 86.43446601941747 0.4685851027775424 0.4381258038241513 10.546552774557412 6.275478278783705 1.570513830163352 0.3792860784147517 5.4826810840958276e-08 9.34487732836072e-05 3.26793645008948e-07 1.3676184949449754e-06 6.51373123685859e-07 +Protein n linked glycosylation 6 17 2.3164957755235123 0.0205312148282372 6.177184466019417 18.78640776699029 0.2004880128160887 0.4683260162783809 3.1676710128395498 3.0254598797887766 1.208633498192774 0.333447209788965 0.0719667164207931 1.0 1.0 0.4015263058449369 0.0570529296125973 +Proteoglycan biosynthetic process 3 6 2.3132161093309698 0.0207107603015905 2.6432038834951457 6.677184466019417 0.8965384350791714 0.2873226841395866 1.6239641738792057 1.992745053805788 1.1569297556833695 0.2755887487741971 0.0468677316875792 0.1524760813950871 0.0443091130960601 0.051542815486873 0.087821349317486 +Mitochondrial cytochrome c oxidase assembly 5 6 2.3100068076531777 0.0208877772338484 2.344660194174758 5.764563106796117 0.9954600272926416 0.2681565835601643 1.449018962088891 1.4364892997002987 1.2150903662861117 0.2820677765861404 0.0013726902925657 0.0987043131013681 0.018640880521655 0.0017174581383874 0.0034992238505004 +Glycolipid catabolic process 4 7 2.3081332106166057 0.0209917285357541 3.6310679611650487 6.451456310679611 0.1059933679561382 0.1697430158083476 1.434595381284437 0.7664524352299261 1.9023109688101565 0.2365791262889882 5.712917963828504e-05 1.0 0.1094892401774078 0.0025975272437437 0.0001575214550341 +Mitochondrial electron transport ubiquinol to cytochrome c 2 5 2.30329675841902 0.0212621519071658 1.5048543689320388 4.206310679611651 0.8658650693935839 0.2665349265497743 0.9514810775456936 0.7935779738409815 1.3072925004771625 0.2886561243868636 0.004218554219783 0.0007650215967213 0.0031504918831051 0.0186627473263165 0.0076703518288617 +Vitamin transmembrane transport 5 6 2.2957852069577034 0.0216881656781389 2.9344660194174756 6.094660194174757 1.6910321805591797 0.1136175735100163 1.344920850275403 0.8913122381585616 1.0580472895861666 0.1862049292817703 0.0001964363060589 0.0683810764565047 0.1349531130589082 0.0495157384890535 0.0005289198821125 +Amino acid import 7 9 2.292575010988804 0.0218724844207132 3.441747572815534 8.407766990291263 0.4366482113195755 0.401453661361528 1.9997584452111057 1.165331680805512 1.104576970757323 0.3040222614424157 0.3157728908665094 1.0 0.2445730022705269 0.5079876539292768 0.4145551447304083 +Nucleotide transmembrane transport 7 8 2.288312074375697 0.0221193538570283 4.029126213592233 9.24271844660194 1.3657020532080593 0.1972377481261837 2.230443861436908 1.484326001257553 1.1744026177454787 0.2553979780962895 0.1284017178718295 0.0727733471903131 0.1432798584585485 0.0557098434243155 0.1807018090276839 +Export across plasma membrane 6 9 2.282705017244823 0.0224477500578701 3.342233009708738 8.672330097087379 0.659462409318522 0.3364871063656119 2.046038764373277 1.5847916183398325 1.1961171404298503 0.3001696886640556 0.0285470554162702 1.0 1.0 0.1627514901813832 0.0553856285019619 +Response to nicotine 0 5 2.2803900500170093 0.022584565218487 0.9684466019417476 5.080097087378641 0.5068538891293205 0.4736423969944768 1.262404284389805 1.3885425726317988 0.8599192085593864 0.2781778596016942 0.6327590455131672 1.0 1.0 0.4573561220916043 0.7122509845733965 +Mitochondrial atp synthesis coupled proton transport 4 11 2.2779003282800976 0.0227325167255465 3.9927184466019416 10.769417475728156 0.5022502301293951 0.29867761594221 2.4440229028906213 0.8937412640542226 1.3849431163992842 0.2834040324316194 0.0046090980714051 0.0031646532309382 0.0006327439593496 0.0086586519898169 0.0013369974246366 +Retrograde vesicle mediated transport golgi to endoplasmic reticulum 13 29 2.269031083508998 0.0232664356924967 7.771844660194175 26.825242718446603 1.1714448828781496 0.3436005361805324 3.811248488859092 3.450558374586287 1.1733172803389544 0.345676809182098 0.0004287665123227 0.1993158438338612 0.0102837000876808 0.0001205669908138 0.0017199102450681 +Membrane protein proteolysis 7 13 2.268883773056079 0.023275394767898 4.138349514563107 11.781553398058252 1.0093176076341577 0.3069750059979975 2.078037067185485 1.3902746514167437 1.0484204695389652 0.2877212872591311 0.0043475295844359 1.0 1.0 0.6242434222626774 0.0028137185393519 +Aminoglycan biosynthetic process 5 9 2.268470348251464 0.0233005542921074 3.0800970873786406 8.300970873786408 0.6387272076133388 0.2830924102482349 1.486473637192798 1.7113836533227735 1.3163721030030058 0.2655273000426038 0.0055637172478833 0.1801156574188796 0.0075361578498098 0.0180565405233996 0.0150707717640174 +Amyloid precursor protein metabolic process 6 17 2.2669112603767942 0.0233956472111191 5.91747572815534 20.04368932038835 1.2306110398413417 0.2828388345239639 2.574706211328507 3.0661056512526157 1.0127867956133585 0.2841981221806073 0.0636242635985585 0.2291240669446297 0.0157478410048603 0.0102355224712358 0.0164244734054917 +Peptide catabolic process 5 10 2.262401451112488 0.023672611362713 3.871359223300971 10.351941747572816 1.5413280472635258 0.1625248535751528 1.454973091229298 0.9501768442987896 1.1353491763523988 0.2229381591694359 0.0006679426562608 0.0858288536093336 0.014058804472369 0.000963248429344 0.000200465132953 +Ceramide biosynthetic process 3 8 2.262082656234362 0.0236922969545785 4.033980582524272 10.24757281553398 1.048715387316577 0.2344614502118888 2.237979905601341 2.0281678881596505 1.4071730245015133 0.2685344998940062 0.0468677316875792 0.1524760813950871 0.2872333566147377 0.2064377407436189 0.087821349317486 +Amyloid beta formation 4 11 2.258055906723336 0.023942174155459 3.4466019417475726 11.150485436893204 0.7369482521385301 0.3719348072839057 1.602353580483856 1.6769930201386472 1.043709172018907 0.2948415726419107 0.0098649842593816 0.1484538203623246 0.0041517217414646 0.0012324742743759 0.0053527619374205 +Early endosome to golgi transport 5 8 2.2537555619439877 0.0242115498224129 2.320388349514563 6.650485436893204 1.001706299736163 0.3202433583076141 1.526233973035193 1.1381191933763375 0.8656979853859356 0.2689019049302471 0.0101209673779209 1.0 0.1094892401774078 0.032628233248221 0.018020673376298 +Diol metabolic process 3 8 2.252067162546252 0.0243180280560839 2.5315533980582523 7.747572815533981 0.934609081792458 0.2730932800244148 1.324333323602112 0.9054146354978068 1.183401939154622 0.2688651038177358 0.002916997936102 0.0727733471903131 0.1432798584585485 0.3236592382947187 0.0062633876942655 +Diol biosynthetic process 3 8 2.252067162546252 0.0243180280560839 2.5315533980582523 7.747572815533981 0.934609081792458 0.2730932800244148 1.324333323602112 0.9054146354978068 1.183401939154622 0.2688651038177358 0.0012582535978488 0.0595353304203936 0.1180585699575878 0.2721697661507766 0.0027630263410089 +Alcohol metabolic process 24 82 2.251823096265964 0.0243334535263017 19.300970873786408 81.99029126213593 1.0392616248309592 0.3936245775900834 6.9548962308345 7.403089286448431 1.208378917036781 0.3759976884392474 2.336611236952492e-05 0.2582163939168242 0.1417075877652198 0.0047266194080703 2.685349699491333e-05 +Purine containing compound transmembrane transport 6 8 2.2436283194177102 0.0248563255918869 3.6432038834951457 8.228155339805825 0.8480777288434221 0.3004167480224937 2.0847056152178514 1.431742605530374 1.2278207398320582 0.2967021731271802 0.4291698817397404 1.0 1.0 0.2897526236095206 0.5020158400168588 +Iron ion transport 7 11 2.23597408751579 0.0253534685867684 2.8762135922330097 9.3252427184466 0.6984692822717036 0.3339124009240178 1.7603279794274296 1.4434464182805606 1.1549328537786283 0.2828654848729625 0.0086872632138223 0.0104419310742173 0.0398064357050217 0.0444854600227105 0.0203628052401783 +Bone morphogenesis 3 7 2.2337811422860026 0.0254974769310196 2.3737864077669903 7.519417475728155 0.7918915806069479 0.3290665752918499 1.3241931901591228 1.4011478132752644 1.0549507058478411 0.2731796281548322 0.0988501735851532 1.0 0.0693457394610891 0.2961580697833918 0.1732034237667374 +Steroid biosynthetic process 14 44 2.233463617131539 0.0255183870089086 11.728155339805824 44.80825242718446 0.9874364787035632 0.3935759881445143 5.016369659264937 4.35272817633461 1.2862817592315925 0.3680333006848349 0.0003930149598911 0.3686542667077518 0.6098780660493645 0.0296866330747937 6.189616675557875e-05 +Mannosylation 3 8 2.232343200823045 0.0255922886946022 2.6262135922330097 6.966019417475728 0.6104715271961744 0.3620085753936749 1.5520397580890246 1.435949900284761 1.1183031747274563 0.2897179829421447 0.0200343776441642 1.0 0.2297987482657219 0.1374615323876937 0.0397044670530444 +Receptor recycling 1 7 2.231288638409944 0.0256620157818054 1.83252427184466 7.075242718446602 0.2017018942761934 0.4536082228606722 1.6905248328776263 1.154000508707628 1.0635166063679875 0.2938337757297349 0.2716923318580232 0.1155957163384056 0.0255840399150975 0.1292409073430241 0.3621483333283614 +Mitochondrion organization 78 191 2.228728217525932 0.0258319935868494 56.45873786407767 188.26941747572815 1.5905300936136977 0.4100157441778524 20.15716756472138 18.40319032732565 2.034523716094369 0.4327537677377048 4.4516088535598464e-18 0.0001640373770479 7.088869679689821e-07 6.588314872579034e-11 6.164918190627336e-19 +Import into cell 15 30 2.2230986396317527 0.0262091493691321 8.441747572815533 26.468446601941743 0.278986899549401 0.5712036628248293 4.717145431684204 4.63434566286081 0.9247855241772484 0.3264760057770247 0.5559328343601505 1.0 0.6211264656767345 0.6995311108717109 0.5382567741709684 +Vascular transport 7 14 2.220912860258834 0.0263568640219287 4.774271844660194 13.094660194174756 0.7274519419599351 0.3186647470404632 2.3913310677559982 2.1617303908189505 1.2183781465172474 0.2807075669512824 0.5894349014223708 1.0 0.3837329617110586 0.3407321567572847 0.4404396671456285 +Glycolipid biosynthetic process 5 8 2.2132504652691107 0.0268803826178005 3.3009708737864076 8.701456310679612 0.8778541677747596 0.2891249509557468 2.0940737065519093 2.1465026455410077 1.206628042966233 0.2848826766737565 0.0511587047594285 1.0 0.2941077913158182 0.0106277501006418 0.0287420990175065 +Ion homeostasis 47 110 2.21283111515295 0.026909291245208 28.021844660194176 105.69174757281552 0.8349951537384392 0.4299135801564597 10.40966729997928 11.411952082971936 1.4722934854811005 0.3963893325418664 6.333193272732474e-06 0.4664905285776053 0.3963517524522892 0.0028194701470885 1.81198636173655e-06 +Atp synthesis coupled proton transport 4 12 2.211358768947548 0.0270110026510113 4.067961165048544 11.769417475728156 0.4798560195228825 0.3249136059986872 2.5150503707528173 0.8937412640542226 1.340203957668315 0.2941072770431484 0.0068595428648402 0.0039064712270754 0.0008717411361388 0.0116756742779249 0.00223229240551 +Amyloid beta metabolic process 4 13 2.19431171289537 0.0282130079776476 3.6771844660194177 13.24514563106796 0.6724101183977472 0.416551332754989 1.8088680779022668 1.8049556184618043 1.0101286409291856 0.3102485572243311 0.0212683179427052 0.1762218760282218 0.0070463522145746 0.0028945217060241 0.0134528362725409 +C4 dicarboxylate transport 7 8 2.1929397296377746 0.0283117217672659 3.441747572815534 7.932038834951456 0.5521079717004741 0.3962643111056436 2.364585978327258 1.2048618010613894 1.0992451565958017 0.3113965023368303 0.1557086547662877 1.0 0.1596960736798767 0.3559534457378639 0.0539281835546241 +Endoplasmic reticulum calcium ion homeostasis 4 8 2.183160836624308 0.029023967716186 3.412621359223301 8.468446601941748 0.7163576234395546 0.3718536853795897 2.0059706805420334 1.5568434939403433 1.1166052913833018 0.3156746531372333 0.0013726902925657 1.0 1.0 0.0152248647419399 0.0034992238505004 +Positive regulation of blood circulation 2 5 2.161591975024487 0.0306496405723804 1.6116504854368932 3.924757281553398 0.6685578971888424 0.3646934888838808 1.007091454748733 1.005648459742718 1.1685725886577618 0.3064822812176077 0.0127797815125809 1.0 0.1180585699575878 0.0033170374819039 0.0225979674873623 +Phosphatidylcholine metabolic process 4 13 2.158278973127796 0.0309061485259856 3.75 12.592233009708735 0.9144963280277142 0.2812959412325629 1.879404212556404 2.4412987678409657 1.1545250012369797 0.2602001877022786 0.017409601938399 1.0 1.0 0.0140312853386763 0.0390278099301106 +Amyloid precursor protein catabolic process 6 14 2.1536225321699964 0.0312697857784676 4.62621359223301 16.47087378640777 1.203006467000838 0.2754962460876 2.1329801006381106 2.1803683249886516 0.947433834000198 0.2709877848980267 0.028033858543733 0.1878492321971458 0.0085749794431607 0.0039562767661884 0.0048940429574069 +Endochondral bone morphogenesis 2 5 2.1489623315243893 0.0316373860576257 1.6480582524271843 5.594660194174757 0.7038217123315962 0.3729755664973352 1.1864612949328115 1.0785960989759678 0.9833570305213049 0.2787707264141815 0.1033774389046965 1.0 0.031373049189738 0.154226710893935 0.1645088237572309 +Sulfur compound transport 6 8 2.1431037978758187 0.0321047645785881 3.504854368932039 9.429611650485436 1.339223354728307 0.2167503093092372 2.046184165461596 2.1092484385198076 1.0728301411615704 0.2604171804663498 0.0389124626724657 1.0 0.2732850813359189 0.0444854600227105 0.07392944267488 +Calcium ion import 7 14 2.1410867290957167 0.032267044675309 4.516990291262136 12.686893203883496 1.0417029373125424 0.2391249176108038 2.3196506830054986 1.9148178088324157 1.3383409214307818 0.27915846054651 0.0556573154678241 0.1604648724397155 0.048990890514732 0.0591065206713347 0.0081853110588452 +Protein localization to extracellular region 16 58 2.135345070624467 0.032732833942948 14.08980582524272 60.1626213592233 0.3740636626751541 0.6804633719835338 5.5124918123942495 7.043227203431352 0.6880222056686158 0.320722083725093 0.0622422956405082 0.2180602949831368 0.536804044935112 0.0146804600150792 0.0685290085705725 +Sphingoid metabolic process 3 5 2.133823096035982 0.0328572645550917 2.337378640776699 5.174757281553398 0.8258730035764346 0.2192038420096116 1.196784089801513 0.5941001920342514 1.4738240163378542 0.2563928956394505 0.0058525380795408 0.0461123069087121 0.0921025797166938 0.2167775624926856 0.0009118158302113 +Iron ion homeostasis 6 17 2.12759032776205 0.0333710648660778 4.468446601941747 17.140776699029125 1.0306963602610326 0.26770320823289 2.1032740346004313 1.762496954108992 1.1437451534606062 0.2692749918411525 0.0035351919501872 0.2143583684675494 0.3896854720293997 0.0074685925596388 0.0110551101007063 +Cytoplasmic pattern recognition receptor signaling pathway in response to virus 2 12 2.126748487247179 0.0334409864574762 2.9635922330097086 12.686893203883496 0.2737645916102473 0.5571094352365948 1.9893245935694983 1.7042274844314875 0.8087934351891028 0.290497350329533 0.1033774389046965 0.1280604643503683 0.2445730022705269 0.0319451393300601 0.1645088237572309 +Oligosaccharide metabolic process 3 6 2.125855299949315 0.0335153098091958 3.0606796116504853 6.179611650485437 -0.0148577354153068 0.2267163537664357 1.4017006052191363 1.1242135739548185 1.7186048285621385 0.2671195008920222 0.0114287110152524 1.0 0.1993869387044997 0.0172025832638257 0.0233101974365333 +Protein localization to endoplasmic reticulum 15 35 2.1208107492550345 0.0339377317482234 9.50242718446602 34.50485436893204 0.9935384348474128 0.428255638055916 4.399083524593319 2.6617527855555916 1.1934894982037212 0.3717243536861919 0.0235975326106129 1.0 0.0173242512102645 0.0483010618227088 7.642967523267423e-05 +Response to increased oxygen levels 2 8 2.117227517650408 0.0342405430441195 1.9563106796116505 8.939320388349515 0.9100937072347148 0.3197058737817761 1.2933864561055997 1.001798152387997 1.0059424935454593 0.2746313949658078 0.0416226685335461 1.0 0.1758008751515455 0.0116756742779249 0.0701952648708137 +Protein maturation 27 68 2.1169148684683474 0.0342670735485393 16.635922330097088 69.29611650485437 0.7279397561088901 0.5092233260742579 5.6828366082703345 6.923625268615643 1.0037762420957868 0.3621314209884535 0.0023570732347449 1.0 0.128026117966102 0.054602117773195 0.0018072660234054 +Respiratory chain complex iii assembly 2 5 2.114453342179156 0.0344765658072627 1.8470873786407769 5.160194174757281 1.360931378136811 0.1995688008303064 1.0650749835200868 1.2360161344522411 1.0120439004969468 0.2366879233397748 0.0028961418368086 0.0370595951599339 0.0743799864466655 0.0147480216610697 0.0053031795330487 +Regulation of cholesterol biosynthetic process 3 5 2.113638776896188 0.0345461312511481 1.6650485436893203 4.609223300970874 0.6675921621720221 0.3903379911361398 1.2205528540330282 0.9058667354361158 1.013338356321453 0.3026321490998659 0.0229393586787355 1.0 1.0 1.0 0.0062633876942655 +Regulation of alcohol biosynthetic process 3 5 2.113638776896188 0.0345461312511481 1.6771844660194175 4.694174757281553 0.6441414994535534 0.3918503348179894 1.2287667805258018 0.964750105248192 1.022157937878104 0.3006721743490211 0.0875376569601171 1.0 1.0 1.0 0.0397044670530444 +Regulation of vacuole organization 6 14 2.1057534242973404 0.0352257765109309 2.8567961165048543 11.82766990291262 0.1258946546155446 0.4588976974701806 2.33512175670257 2.002889031763913 1.0406614763927915 0.2804453828965037 0.0988501735851532 0.1916891885455893 0.3530974878629287 0.6676078298658026 0.1732034237667374 +O glycan processing 2 5 2.1006381852374 0.0356727393680338 1.8762135922330097 5.029126213592233 0.779006640385936 0.3319918611732407 1.1540209287066336 1.1758600296433448 1.0243123329907684 0.2736840802111854 0.0659351237154193 1.0 0.2070995190727305 0.0193169154759243 0.1083207684216986 +Protein exit from endoplasmic reticulum 11 21 2.099547396286064 0.0357686743291494 7.002427184466019 21.233009708737864 0.6943602976218084 0.4745028866201709 3.210645812910548 2.182026685495945 1.0430444956616387 0.3507892727806736 0.0256449511882959 0.1839914155878272 0.3404254693467198 0.6508948194595567 0.0168189007239576 +Folic acid metabolic process 3 8 2.0983623262348408 0.0358731506299003 1.91747572815534 7.140776699029126 1.2977645388348351 0.249592124826322 1.215987926650751 0.8615786924829095 0.8405378716662024 0.2600707347072601 0.1024144220510148 0.0639684350193291 0.1265462710440741 0.2897526236095206 0.0277461310389573 +Mitochondrial calcium ion transmembrane transport 8 10 2.0945419314217 0.0362117318478105 3.4684466019417477 9.04126213592233 0.7792467211325117 0.2463779000555085 2.196969341156949 1.2010296388602075 1.3738174116662032 0.263849842646199 0.0229393586787355 0.0727733471903131 0.1432798584585485 0.3236592382947187 0.0062633876942655 +Cellular respiration 27 106 2.0936334923901887 0.036292641640842 27.975728155339805 102.1019417475728 0.3887198796668061 0.4496840882999475 12.70690482749566 7.191843824002275 1.6294784865611704 0.3894421445164553 4.915477681075383e-09 2.605211951833608e-05 2.346178910411689e-07 6.69150472004988e-07 3.038610429048605e-08 +Vacuolar acidification 3 9 2.086656284303708 0.0369192155766138 3.4757281553398056 8.922330097087379 1.27407749822917 0.1611429668415415 1.4148632661931722 1.303016071016461 1.4195929612668792 0.2212670077717619 0.0046090980714051 0.0814971443263516 0.0006327439593496 0.0007750266814789 0.0097510399506001 +Cell recognition 3 21 2.0750578257142056 0.0379811758126238 5.29126213592233 22.859223300970875 0.9056944851933356 0.3618031966115522 2.859598274322472 2.538937048941188 0.9847101891513528 0.3060121099700091 0.2168319745971527 0.2507644527164699 0.1163398228410075 0.0593060830293246 0.3438081646501767 +Atp biosynthetic process 7 20 2.0720704490459942 0.0382588717240468 6.262135922330097 20.148058252427184 0.2780500302004456 0.4469732075673486 3.3282000880634137 1.2978402958376112 1.0861992627517016 0.3097712264878526 0.0043475295844359 0.0151070197534971 0.000562497610511 0.0153023562212604 0.0005666628036471 +Phosphatidylglycerol metabolic process 3 8 2.0680505863945977 0.0386352665270315 3.7572815533980584 10.78640776699029 0.7074456860764219 0.3298030384317407 2.521619218643941 1.658461595229837 1.2128783939533223 0.2875854965146425 0.0728326355906942 1.0 1.0 0.0215683584236732 0.0308662830144804 +Cartilage development 6 17 2.05677990307298 0.0397074020818144 3.932038834951456 14.283980582524272 0.7074320636322524 0.4287139668901396 2.125947582774665 2.5119975572795252 0.8798730191625526 0.3016172221818579 0.1469404555405523 1.0 0.2178091494673695 0.64921047087108 0.152693888684589 +Response to food 1 6 2.047763961183844 0.0405831331940391 1.720873786407767 5.783980582524272 1.3281223897944048 0.1823213242558801 0.9790282548915298 0.8299231919143666 1.0823564620426191 0.211054619984942 0.0900408634029916 0.0595353304203936 0.0066572828402184 0.0379575415698398 0.1289341732663725 +Mammary gland development 6 22 2.047025478353931 0.0406555830008588 5.216019417475728 20.41747572815534 0.5512318000747981 0.5167791069166561 2.3942560065426757 2.728043047822029 0.8380822573448591 0.3178008321809467 0.048939052832209 1.0 0.0483217377147592 0.1492356701793886 0.1181853417157704 +Organelle membrane fusion 14 33 2.044012256227883 0.0409523363717239 9.026699029126211 29.49271844660194 0.2503440438263548 0.5991935201964022 4.297974887399588 5.110663265938685 0.9179616425810708 0.3357137012753883 0.1163414051507664 1.0 0.1967082241040804 0.0543296939149059 0.0217147780971135 +L glutamate transmembrane transport 6 7 2.04318298150691 0.0410343277921692 3.116504854368932 6.616504854368932 0.3175170990129407 0.3936177213286974 1.7421166172873912 0.8323084155048082 1.211420518243718 0.3212678134420738 0.1024144220510148 1.0 1.0 1.0 0.0277461310389573 +Heparan sulfate proteoglycan biosynthetic process 2 5 2.042595289891456 0.0410925177637016 1.7160194174757282 5.026699029126213 0.5645930836787868 0.419729099473023 1.1572631253827 1.3516497566885952 1.0187409340025655 0.3042431327777389 0.0364081996833034 0.0858288536093336 0.1677870330809631 0.0757571260003459 0.0618109910728358 +Heparan sulfate proteoglycan metabolic process 2 5 2.042595289891456 0.0410925177637016 1.766990291262136 5.121359223300971 0.5642898647972117 0.4173053251695717 1.1613006057834978 1.389918659730618 1.0230121456430192 0.3027926697750463 0.0593556147738179 0.1029565435856987 0.1993869387044997 0.1053546389470493 0.0981468657129251 +Membrane protein ectodomain proteolysis 4 10 2.041685086925807 0.0411827790004213 3.2815533980582523 9.42233009708738 0.914660566901433 0.3175120830558543 1.6482852268027584 1.2623319489295757 0.9882621955102872 0.2679281534911034 0.0066301296997015 1.0 1.0 0.5315101420828222 0.0157766780310383 +Neutral lipid metabolic process 5 14 2.039529958025412 0.0413971644464592 3.7645631067961167 14.638349514563108 -0.2959545341177167 0.2756576316525815 2.469308018590983 2.835760748630011 1.4124950075268554 0.2284226385878861 0.0470159094837035 0.2718096468929847 0.4775398588675821 0.0780890051531907 0.1056700414064192 +Iron ion transmembrane transport 3 5 2.039234350615511 0.0414266441240069 1.2402912621359223 3.104368932038835 0.4251219304669178 0.3841185556700066 0.910045295267336 1.1601307006238253 1.3085169053587704 0.3098538781320883 0.0012582535978488 0.0595353304203936 0.1180585699575878 0.0379575415698398 0.0027630263410089 +Circulatory system process 18 74 2.037996758640956 0.0415502570320442 17.152912621359224 72.00970873786407 0.7968086684699157 0.4206667688960129 5.8797345113877215 8.195718922280731 1.282615010632819 0.3676426088525382 0.0069345548642199 0.6851649519905939 0.0289369860172545 0.005822823094232 0.0264331914580258 +Inorganic anion transmembrane transport 5 8 2.033826222688612 0.0419691196393372 3.4101941747572817 8.983009708737864 1.1245392058053427 0.2357455210082705 2.3748669786284156 1.7214248641786654 1.1968417731555627 0.2697184972505711 0.1033774389046965 0.1280604643503683 0.031373049189738 0.154226710893935 0.1645088237572309 +Sensory perception of light stimulus 4 14 2.033492215127568 0.0420028192870334 5.009708737864078 15.96359223300971 0.918103407248628 0.3572194322029593 2.4583724414330383 3.147064390877318 0.9947617981182544 0.3055434177582076 0.1163882579979216 0.2683427616475903 0.0254749821013702 0.0212699465140733 0.1000607998149871 +Antiviral innate immune response 2 5 2.032152107247017 0.0421382596353845 2.4441747572815533 4.966019417475728 0.1790207298991634 0.4762932720756598 1.3399355326267808 0.1811792000633157 1.0134461763149525 0.3105069800064801 0.0560883044213639 1.0 1.0 0.0229613270793894 0.0817606313480972 +Regulation of cholesterol metabolic process 3 6 2.031780402121197 0.0421758920625259 2.2936893203883497 7.036407766990291 0.4249970400619817 0.3648416816190511 1.505220359503101 1.431658251221006 1.1754439785533268 0.2764552996129673 0.0659351237154193 1.0 1.0 1.0 0.0269295467729808 +Ph reduction 6 13 2.0285083722070443 0.0425083897029499 4.422330097087379 12.509708737864075 1.1966830084586066 0.1930048880851129 1.91475781321527 1.7851607614701208 1.4167744165903868 0.2497649393583847 0.0042223202801658 0.1239247827595126 0.0023694947377154 0.0042924995678 0.001918269568256 +Copper ion homeostasis 5 6 2.0240258796312163 0.0429674890201123 1.6771844660194175 4.669902912621359 0.4484316971142749 0.3058603694529516 1.2128614304476144 1.4202990900289796 1.3716690980071935 0.284002300922153 0.002916997936102 1.0 1.0 0.3236592382947187 0.0062633876942655 +Organophosphate catabolic process 7 36 2.020639545704487 0.0433170921166008 6.774271844660194 36.1626213592233 -0.2921408084661334 0.4220223947837425 3.717580668013521 4.268336903829444 1.180846654986601 0.3079166774800768 0.0589652108234748 1.0 0.0195066935662917 0.0147861479784934 0.1482732403897816 +Sterol biosynthetic process 15 26 2.018735973836073 0.0435146688672649 7.281553398058253 24.52912621359223 1.190088798384403 0.3136799329736269 3.292879861326439 2.61838648411319 1.1232845583768152 0.3105481837594456 0.0004287665123227 1.0 1.0 0.0262238710799836 1.1206321672316697e-05 +Cerebellar purkinje cell layer development 3 9 2.0180159680615835 0.0435895983293763 2.191747572815534 6.961165048543689 0.8392766864609098 0.2843914142715297 1.2383946131318218 1.2878998490964535 1.1730456034866912 0.2696789702944095 0.0046090980714051 0.0814971443263516 0.1596960736798767 0.0688460117016781 0.0097510399506001 +Negative regulation of amyloid precursor protein catabolic process 3 9 2.013185101352726 0.0440951600054448 2.645631067961165 8.78883495145631 0.7296788020743029 0.3749260712143212 1.4314957008524525 1.1001198531094605 1.057374600950545 0.3066940057573566 0.0036978306683598 0.0771453392642774 0.0005309775927247 0.0006143549700213 0.0010053263520343 +Pigment biosynthetic process 7 25 2.001717496297964 0.0453151235770925 6.191747572815534 23.20631067961165 0.1176426516349437 0.5124018007570521 3.0504861707649304 2.789310208180288 0.9995589703296716 0.3059733010449426 0.0019328992996702 1.0 0.0720571885403784 0.0048028453089964 0.0014891058006406 +Regulation of oxidoreductase activity 8 16 1.995646197801905 0.0459724471944011 4.745145631067961 16.524271844660195 0.8435277245089666 0.3527293456818395 2.542951562396442 1.641953963820047 1.0033906386071183 0.2899852749738094 0.001116781538703 1.0 0.4072036678679048 0.0408612650970917 0.001050513287845 +Positive regulation of mitochondrial translation 1 9 1.994612801101203 0.0460851263380774 1.8155339805825244 7.439320388349515 1.1233950947475233 0.2654033071264799 1.4295601388514203 1.5544197944414198 1.0052042080836443 0.2741718924063684 0.1152189229742136 0.0021914548918381 0.0088504827764808 0.0495157384890535 0.1630814235328921 +Embryonic digit morphogenesis 1 7 1.9908514159789212 0.0464972248068542 1.4684466019417477 6.54126213592233 0.5989020645284063 0.4429704011231127 1.569266266788618 1.559731853735315 0.934963282113679 0.3039103680308826 0.5074160191921855 1.0 0.0640285846884502 0.2781824052676386 0.6247651003553614 +Triglyceride metabolic process 4 10 1.9898371031596505 0.0466088827674551 3.4805825242718447 10.771844660194176 0.9779567044833 0.270555786798488 1.9834538010888536 2.3392770219831345 1.099054194056709 0.249087443977639 0.0452942841491596 0.2106238865638343 0.3837329617110586 0.1193188519501932 0.0937879952817309 +Ceramide transport 2 5 1.9857854022393264 0.0470571573401787 1.779126213592233 5.310679611650485 0.994079753441996 0.2057455404068654 1.027416031856974 0.785538294365343 1.3065287972688011 0.2361222749942 0.0127797815125809 1.0 1.0 0.0033170374819039 0.0225979674873623 +Regulation of pattern recognition receptor signaling pathway 2 15 1.985752457351936 0.0470608171296069 4.691747572815534 19.70873786407767 0.80673262224624 0.4173389113947272 2.517825740704142 3.173406084005513 0.919675411949683 0.3119180769844089 0.4412709161763688 0.2543128795765555 0.1194965359594502 0.1881433143308717 0.5853384905806133 +Macromolecule depalmitoylation 2 6 1.9846028985303852 0.0471886696118861 1.91747572815534 5.429611650485437 0.9780254626091984 0.222941388490727 1.137611804765983 0.8139540579221628 1.3123017012345466 0.2566673774233151 0.0101209673779209 0.0550816697898294 0.1094892401774078 0.0025975272437437 0.018020673376298 +Atp transport 5 6 1.9843159745467844 0.0472206264551635 3.4805825242718447 6.233009708737864 0.5838786306840471 0.3211615036091749 1.83337760624298 0.8807971179633459 1.3636108978108328 0.3170401972517012 0.0460411511547768 1.0 1.0 0.1973959389561772 0.0675218785318175 +Isoprenoid metabolic process 7 25 1.9773538822474912 0.0480016430292045 6.351941747572815 23.436893203883496 0.371913197601784 0.4325927382253215 2.8701546111232905 3.133501725907374 1.111400072689174 0.3110459828013394 0.0054203617037941 0.2291240669446297 0.0978881295505725 0.0102355224712358 0.0047453897441578 +Phosphatidylinositol biosynthetic process 8 20 1.971865128343284 0.0486250050672467 6.497572815533981 21.75485436893204 0.2324608584633621 0.5823932566767777 3.2482248971649077 5.447062157148579 0.8872279359639678 0.3154734680996093 0.3321934402638749 1.0 0.2391023108138102 0.4161207629557325 0.1913042575933133 +Fat soluble vitamin metabolic process 2 5 1.9699382874544955 0.0488454437157492 2.3228155339805827 6.029126213592233 -0.0382340901065817 0.3265184074050073 1.1512609528279278 1.1942931506548955 1.2852584674393026 0.2375275324628412 0.0229393586787355 0.0727733471903131 0.1432798584585485 0.3236592382947187 0.0397387250697101 +Regulation of release of cytochrome c from mitochondria 6 11 1.965367009488134 0.0493717749631732 3.6310679611650487 10.805825242718448 0.7924389389582319 0.4006886058463786 1.815469081442188 1.3603843861930187 0.9712392086725492 0.3199873643457663 0.0066301296997015 0.1362745587685063 0.2590666885683055 0.1713585638073601 0.0033138804057902 +Neuron maturation 1 5 1.9653416705263629 0.0493747056681739 1.6966019417475728 5.737864077669903 0.3884050692002241 0.3270287101850628 1.1310653568868725 1.188220216330287 1.2760249805885358 0.2674215567147113 0.2569496365349507 1.0 0.2147385524083838 0.1211421538065826 0.3442759855295882 +Calcium import into the mitochondrion 6 7 1.9639312957256845 0.0495380599569927 2.4563106796116503 6.04126213592233 0.8091317576129835 0.2214807715451704 1.7082137325011066 1.2010296388602073 1.3762222767333927 0.2421218388926935 0.0781545431116171 0.0550816697898294 0.1094892401774078 0.2541534411772372 0.018020673376298 +Mitochondrial calcium ion homeostasis 8 11 1.9623783954794929 0.0497184461462232 4.62621359223301 10.509708737864075 0.2790428491871666 0.3774917598770124 2.1634860921400008 1.7383182679254283 1.294226020505384 0.3175561312397286 0.00821576936754 1.0 1.0 0.4015375820029667 0.0028145739091465 diff --git a/msigdb_gobp/metrics.json b/msigdb_gobp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..19fd7ebbf83fc099e710edf1a36f4bebf2a27183 --- /dev/null +++ b/msigdb_gobp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3120, + "annotations_size": 6492, + "title": "Average number of proteins per term", + "value": 18.90988909426987 +} \ No newline at end of file diff --git a/msigdb_gobp/paths.json b/msigdb_gobp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..0fa65388e35e79b0b674ab76ec2130995b0bea86 --- /dev/null +++ b/msigdb_gobp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gobp/fragment/C390/C390_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gobp/result.tsv b/msigdb_gobp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..022d510408d965d935830b4bcb056153e953ae97 --- /dev/null +++ b/msigdb_gobp/result.tsv @@ -0,0 +1,1595 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Anion transport 0.6274968116367078 4.243047985714493 2.2050426251141175e-05 0.1333784871190637 0.0580074461827603 70 O75915,Q9NW15,P41440,Q6NUK1,P0CG08,Q9H936,Q9H9B4,Q9H2D1,Q02978,Q9UHG3,Q9Y277,O43808,Q15041,Q15907,P21796,Q14728,Q8TDW0,P08195,O60831,O75746,Q9BQT8,P45880,Q96NB2,Q9UJS0,Q9NZD2,Q9NY64,P08183,P12235,Q8TB61,Q08722,P30825,Q15043,P05556,Q9UBX3,P30536,Q9NZJ7,P05141,P12236,O43681,Q9H0H5,Q15758,Q9HC21,P51790,Q4KMQ2,Q9Y6M7,Q13546 46 +Mitochondrial transmembrane transport 0.7009014097095404 4.223888258014254 2.4012313978083455e-05 0.1443465337823112 0.0580074461827603 49 O75027,Q9H9B4,Q9H2D1,Q3ZCQ8,P21796,O95202,O43615,P23786,O60830,O75964,P50416,O75947,O43772,P24539,Q9BQT8,O75746,Q96NB2,Q9UJS0,O14925,P00846,P12235,Q9Y4W6,P06576,O95831,P05141,P56385,Q8NE86,Q9BPX6,Q15388,P12236,Q6P4A7,O96008,Q9UJZ1,Q8WWC4,Q8IYU8 35 +Anion transmembrane transport 0.7327420690036239 4.19903356319418 2.680565904933374e-05 0.1597238330352288 0.0580074461827603 41 O75915,P41440,Q9H936,Q9H9B4,Q9H2D1,Q02978,Q9UHG3,Q9Y277,O43808,Q15041,P21796,Q14728,Q8TDW0,P08195,O60831,O75746,Q9BQT8,P45880,Q96NB2,Q9UJS0,P08183,P12235,Q8TB61,P30825,P05556,Q9UBX3,P05141,P12236,Q15758,Q9HC21,P51790,Q4KMQ2,Q9Y6M7,Q13546 34 +Mitochondrial transport 0.6294832947166886 4.117587469597863 3.8285923580128056e-05 0.2200745759246238 0.0621380539705494 83 Q6NUK1,Q8N4H5,Q9H300,Q9NS69,Q9P0J0,Q3ZCQ8,P23786,O60830,O75964,P50416,O43772,P24539,Q53H12,P45880,Q9UJS0,Q10713,O14925,P00846,Q9Y512,P52789,Q15070,Q9GZY8,O95831,P06576,P55786,P51572,Q9UBX3,P30536,Q9BZL1,Q9Y5J9,P56385,Q15388,O14737,O75431,Q9Y371,Q9Y276,O95140,Q5JRX3 38 +Membrane lipid metabolic process 0.7317004685853774 4.059811677418075 4.911231092274981e-05 0.2730117414874809 0.0637674245020996 36 Q06136,P04062,O15269,P06280,Q13510,Q53H12,P50897,Q9NZD2,Q11206,P17900,Q99805,Q9P035,Q8NBX0,Q9NZJ7,Q5H8A4,O95470,P04066,P16278,Q8NCC3,P06865 20 +Protein localization to mitochondrion 0.6115437758101303 3.946924389578105 7.916154260190211e-05 0.401863970527699 0.0856527890952591 60 Q8N4H5,Q9H300,Q9NS69,Q9P0J0,Q3ZCQ8,O60830,Q53H12,Q10713,O14925,Q9Y512,P52789,Q9GZY8,Q15070,O95831,P55786,P51572,Q9BZL1,Q9Y5J9,P30536,Q15388,Q9Y6C9,O14737,Q9Y371,Q9Y276,O95140,O96008,Q5JRX3 27 +Mitochondrial respiratory chain complex assembly 0.6949340167989021 3.8909897881928943 9.98361350619259e-05 0.4769972436595173 0.0925908841174327 40 Q9H061,Q8IUX1,Q96E52,O95169,Q86Y39,Q15070,O95831,Q9P0J0,Q96CU9,Q9Y6M9,Q9Y276,O96000,Q9Y2R0,O75880,Q69YU5,O95168,O43819,Q9Y512 18 +Mitochondrial membrane organization 0.6660966125073159 3.78155002117849 0.0001558548962798 0.6364683234495376 0.1264762483311351 44 Q5XKP0,Q9NS69,Q9P0J0,Q3ZCQ8,O95202,Q9NVH1,Q9BUR5,Q53H12,P45880,Q13505,Q9NX63,Q9Y512,P12235,Q6UXV4,P52789,Q15070,O60313,Q16891,Q9Y5J9,Q96E52,O14737,O75431,Q9Y276,Q9H3K2,O95140 25 +Sphingolipid metabolic process 0.7462074843769765 3.738365106118082 0.0001852208294428 0.6995773607422868 0.1265566150224194 27 P06280,P17900,Q99805,Q13510,Q9P035,O95470,Q53H12,P50897,P04062,P16278,Q9NZJ7,O15269,Q8NCC3,P06865,Q9NZD2 15 +Organic anion transport 0.6452006113253963 3.70729044324294 0.0002094886377843 0.7433758481568973 0.1265566150224194 47 Q9H936,P41440,Q6NUK1,Q9H9B4,Q9H2D1,Q02978,O43808,Q15041,Q14728,Q8TDW0,P08195,O60831,O75746,Q9BQT8,Q96NB2,Q9UJS0,Q9NZD2,Q9NY64,P12235,Q8TB61,Q08722,P30825,P05556,Q9UBX3,Q9NZJ7,P05141,P12236,Q15758,Q9HC21,Q9Y6M7,O75915 31 +Organic acid transmembrane transport 0.7081164633058195 3.668097562794492 0.0002443619448366 0.79537814338213 0.1321998121566442 30 P41440,Q9H936,Q9H9B4,Q9H2D1,Q15041,P23786,P31751,Q8TDW0,P50416,O43772,P08195,O60831,O75746,Q9BQT8,Q96NB2,Q9UJS0,P08183,P30825,P05556,Q9UBX3,Q15758,O75915 22 +Inner mitochondrial membrane organization 0.7751538855606782 3.614652920175154 0.0003007502579539 0.858118678732178 0.1501900518951588 21 Q96E52,Q6UXV4,Q5XKP0,Q9BUR5,O75431,Q53H12,Q9P0J0,O60313,Q9H3K2,Q16891,Q13505,Q9Y5J9,O95202,Q9NX63,Q9NVH1,Q9Y512 16 +Protein targeting to mitochondrion 0.625773771235253 3.579465971109962 0.0003442970760358 0.8930679281193074 0.1596554726875018 48 Q8N4H5,Q9H300,Q9NS69,Q9P0J0,Q3ZCQ8,O60830,Q53H12,Q10713,O14925,Q9Y512,Q9GZY8,O95831,P55786,P51572,Q9BZL1,Q9Y5J9,P30536,Q15388,O14737,Q9Y371,O95140,O96008,Q5JRX3 23 +Glycoprotein metabolic process 0.562301920725321 3.3948452460680443 0.0006866740232189 0.9884309172314608 0.2856916194006233 58 Q7LGA3,Q9BT22,O15118,Q04656,P46977,Q86YN1,Q96L58,Q10472,Q92542,Q9NX62,Q8NCH0,Q96JB2,Q11206,Q9H0U4,O60476,Q99805,Q9H4A6,Q9BV10,O43505,Q9H6U8 20 +Membrane lipid biosynthetic process 0.724960399344427 3.347160145416039 0.0008164402950321 0.9950208459677358 0.2856916194006233 22 Q99805,Q13510,Q9P035,Q8NBX0,Q5H8A4,O95470,Q53H12,Q06136,P04062,O15269,Q11206 11 +Proton transmembrane transport 0.6046586987039894 3.3405334370083333 0.0008361761116042 0.9956200858482056 0.2856916194006233 46 P13073,P20674,P24539,Q13423,P05023,Q9UDW1,Q99623,Q8TAD4,P51790,Q7KZN9,P00403,P56385,P00846,O75964 14 +Ceramide metabolic process 0.7871176857992221 3.314460358823578 0.0009182019820059 0.9974296305345636 0.2856916194006233 17 P06280,P17900,Q99805,Q13510,O95470,Q53H12,P04062,Q8NCC3,P06865 9 +Oxidative phosphorylation 0.5244684032915528 3.307108516402709 0.0009426436777244 0.997807096668361 0.2856916194006233 64 Q9UDW1,O14949,Q7KZN9,O75964,P13073,P14406,P24539,P14927,O95169,O96000,P00846,P20674,P22695,Q9Y6M9,P56385,P00403,P09622,Q9H3K2,O95168 19 +Organophosphate ester transport 0.6883080281747055 3.297022274986638 0.0009771575116197 0.9982476683146172 0.2856916194006233 26 P08183,P12236,P41440,Q6NUK1,Q14108,P12235,Q8WTV0,Q8TB61,Q96GC9,Q9H2D1,Q08722,Q9HC21,O43808,Q9NZD2,Q8TDW0 15 +Endoplasmic reticulum organization 0.5983317395329814 3.287126227800677 0.0010121545357693 0.9986041264773622 0.2856916194006233 46 Q8N4V1,Q15363,Q15006,P61026,Q9P2W9,Q9NPA0,Q15041,Q5JRA6,Q8NHH9,Q5J8M3,Q00765,Q12907,Q15629,Q8N5M9,Q9H6H4,O95197,Q9NQC3,O14657,O43765,Q12981,O43681,P57088,P46379,Q96A33 24 +Glycoprotein biosynthetic process 0.5777518337019502 3.265562835832312 0.0010924676422123 0.9991717345069292 0.288405190917434 51 O43505,Q7LGA3,Q10472,O60476,Q99805,Q9BT22,Q9BV10,Q9H6U8,O15118,Q04656,P46977,Q92542,Q96JB2,Q86YN1,Q9H4A6,Q8NCH0,Q96L58,Q11206 18 +Protein transmembrane transport 0.6957170227628873 3.2479821556942547 0.0011622655945404 0.9994737933418396 0.288405190917434 24 Q9UGP8,Q15388,O75381,Q07820,Q9NS69,O95831,Q99442,Q3ZCQ8,P49755,O96008,Q15629,O14925,O60830,O75298 14 +Liposaccharide metabolic process 0.7739552554173788 3.2395410612448745 0.0011972222711393 0.999580741685865 0.288405190917434 17 P06280,P17900,Q99805,Q8NBX0,Q5H8A4,P04066,P16278,Q9NZD2,P06865,Q11206 10 +Organic acid transport 0.5986475091583002 3.2344849177323898 0.0012186235678988 0.9996351880612522 0.288405190917434 44 P41440,Q9H936,Q9H9B4,Q9H2D1,Q02978,O43808,Q15041,P23786,P31751,Q8TDW0,P50416,O43772,P08195,O60831,O75746,Q9BQT8,Q96NB2,Q9UJS0,P08183,P30825,P05556,Q9UBX3,Q6P4A7,Q15758,O75915 25 +Glycerolipid metabolic process 0.52175753300298 3.2286197307141085 0.0012438917661257 0.999690444122913 0.288405190917434 63 Q9UG56,Q9NPH0,Q9NTJ5,Q9UBV2,Q99623,Q92643,P50416,Q96N66,Q8NF37,Q53H12,Q9BVG9,Q10713,Q9NX62,P35790,O95674,Q9NZC3,Q8WTV0,Q5H8A4,Q8NCG7,Q8NCC3 20 +Aminoglycan metabolic process 0.773643834030816 3.144267493011702 0.001665031653776 0.9999799723048012 0.3595165495636568 16 O43505,Q7LGA3,P04066,P16278,P15586,P54802,Q9NX62,Q8NCH0,Q96L58,P06865,Q11206 11 +Lytic vacuole organization 0.6787982475301944 3.1353092567866776 0.0017167302890439 0.9999856905512912 0.3595165495636568 24 O14773,P11117,O75503,Q14108,Q9BZG1,P50897,Q9Y3E7,P10253,Q9P253,P04062,O75787,P54802,Q9UQN3 13 +Carboxylic acid transport 0.6141106695202885 3.112485954475102 0.0018551884144271 0.9999941849946924 0.3763713495769004 32 P41440,Q9H936,Q9H9B4,Q9H2D1,Q02978,Q15041,Q8TDW0,P08195,O60831,O75746,Q9BQT8,Q96NB2,Q9UJS0,P30825,P05556,Q9UBX3,Q9NZJ7,Q15758,O75915 19 +Nadh dehydrogenase complex assembly 0.6383465203040242 3.053637214812947 0.0022608530313537 0.9999995846210984 0.4023262686809655 28 Q9H061,O95169,Q86Y39,Q15070,Q9Y276,Q9P0J0,Q96CU9,Q9Y6M9,O96000,Q8IUX1 10 +Glycerolipid biosynthetic process 0.5816552416453998 3.0422614124965004 0.0023480787836616 0.9999997645229228 0.4023262686809655 42 Q96N66,Q8NF37,Q9NUQ2,O95674,P35790,Q8WTV0,Q9UG56,Q5H8A4,O00459,Q9NPH0,Q9NTJ5,Q9BVG9,Q92643,Q96S52,Q10713,Q9NX62,Q8NCC3 17 +Carbohydrate derivative transport 0.7549477007546118 3.0383381556416196 0.0023788684758194 0.9999998072771118 0.4023262686809655 16 P41440,P12235,Q6NUK1,Q8WTV0,Q8TB61,Q08722,L0R6Q1,Q9HC21,O43808,Q9NZD2,Q9NZJ7,Q8TDW0 12 +Tetrapyrrole metabolic process 0.7046057336852957 3.028164220522167 0.0024604434053308 0.9999998866608806 0.4023262686809655 19 P22830,O75027,P30519,P09601,P30536,Q7KZN9,O00264 7 +Cytochrome complex assembly 0.8203855264601553 2.9845071599485773 0.0028403555385372 0.9999999904414074 0.4023262686809655 12 Q15070,Q9Y276,O75880,Q69YU5,Q9Y2R0,Q7KZN9,O43819,Q6DKK2 8 +Organelle fusion 0.5423247823029561 2.977149857718305 0.0029094176131418 0.999999993903 0.4023262686809655 52 Q8TB36,Q9BZG1,O15400,P06493,Q9H300,Q8N2A8,Q13190,P31751,Q9BSR8,Q9H6R6,Q9Y3E7,O43752,Q12846,Q9NX63,Q9UQN3,Q9Y4W6,Q86Y82,Q9GZY8,O60313,O95721,O60499,O95249,Q12981,Q96E52,Q9Y6C9,P02786,Q9P253,O95140,Q9UJZ1,O75396 30 +Steroid metabolic process 0.4971955187961214 2.973789209305864 0.002941470654878 0.9999999950514334 0.4023262686809655 63 O15118,P04062,Q15392,Q12770,Q13510,P04035,Q14534,P16435,P05023,O94905,P30536,P37268,O75845,Q8WTV0,P38571,O95470,Q16850,Q15800,P38435,Q53GQ0 20 +Vacuole organization 0.530158661458846 2.967741574853195 0.0029999643831937 0.9999999966188186 0.4023262686809655 55 O14773,Q9BZG1,Q96GC9,P04062,P11117,P16615,Q14108,Q9UHD9,P50897,Q9Y3E7,Q13099,Q9UQN3,O75503,Q9H0U4,P07686,Q9Y371,P10253,Q9P253,O95140,O75787,P54802,O75396 22 +Respiratory electron transport chain 0.536923990479731 2.960627415199649 0.0030701309963165 0.9999999978589064 0.4023262686809655 53 P13073,P20674,P09622,O95169,P14927,O95168,Q9H3K2,Q9Y6M9,P04062,Q9UDW1,P21912,O96000,Q9UJS0,O14949,Q7KZN9,O43819,P00403 17 +Porphyrin containing compound metabolic process 0.7251849404606926 2.955810852643165 0.003118482712086 0.9999999984372562 0.4023262686809655 17 P22830,O75027,P30519,P09601,P30536,Q7KZN9,O00264 7 +Glycerophospholipid biosynthetic process 0.5806180408164188 2.948650727939288 0.0031916445895756 0.9999999990295808 0.4023262686809655 38 Q9UG56,Q9NPH0,Q9NTJ5,Q92643,Q86UL3,Q8WWI5,Q96N66,Q8NF37,Q969N2,Q8WVX9,Q9BVG9,Q96S52,Q10713,Q9NX62,Q9NUQ2,O95674,P35790,O00459,Q6IAN0,Q8TBX8,Q5H8A4,Q96PE3 22 +Import across plasma membrane 0.6660725217130242 2.926252999296048 0.0034307181292692 0.9999999997955126 0.4023262686809655 21 P05026,P41440,P08195,P05023,P30825,Q15043,Q15758,P05556,P23634,P54709,Q15041,O75915,P31751,Q8TDW0 14 +Atp synthesis coupled electron transport 0.572948640664348 2.9250956812058524 0.0034435032814628 0.9999999998118538 0.4023262686809655 40 P13073,P20674,P09622,O95169,P14927,Q9H3K2,Q9Y6M9,Q9UDW1,O96000,O14949,Q7KZN9,P00403 12 +Endoplasmic reticulum membrane organization 0.878833300446211 2.921837544634471 0.00347972990024 0.999999999851406 0.4023262686809655 9 Q9NQC3,Q15363,Q8NHH9,Q9P2W9,Q15041,Q12981 6 +Membrane lipid catabolic process 0.8055520699807862 2.908717798124464 0.0036291428905401 0.9999999999438643 0.4023262686809655 12 P06280,P17900,Q13510,O95470,P50897,P04066,P06865 7 +Transition metal ion transport 0.7093008268740172 2.8612352345625505 0.0042199381348642 0.999999999998806 0.4023262686809655 17 P98194,O75027,Q8N4V1,Q9H9B4,P02792,Q15043,Q04656,Q8TAD4,Q9HD20,P35670,P02786,Q15907 12 +Intracellular protein transmembrane transport 0.6559984818489533 2.8597077802696957 0.0042403153728105 0.9999999999989546 0.4023262686809655 21 Q9UGP8,Q15388,O75381,O95831,Q99442,Q3ZCQ8,O96008,Q15629,O14925,O60830,O75298 11 +Carbohydrate derivative catabolic process 0.5731874174697552 2.8517718196809767 0.004347629704136 0.9999999999994807 0.4023262686809655 36 P06280,Q9NUJ1,P17900,Q9H773,Q9BTY2,P36639,P00813,P04062,P04066,P16278,P15586,P54802,P06865 13 +Sphingolipid biosynthetic process 0.7332103744306083 2.8301311892608028 0.0046528921110899 0.9999999999999292 0.4023262686809655 15 Q99805,Q13510,Q9P035,O95470,Q53H12,P04062,O15269 7 +Mitochondrial electron transport cytochrome c to oxygen 0.9255982967351836 2.814429640464091 0.0048863872974129 0.9999999999999846 0.4023262686809655 7 P13073,P20674,P00403 3 +Establishment of protein localization to membrane 0.5068216596376113 2.798822428283012 0.0051289334474131 0.9999999999999968 0.4023262686809655 91 Q9BZG1,Q8N4V1,Q15006,P61026,O15118,Q9NS69,Q9P0J0,Q9NPA0,Q9HD20,Q15041,Q15907,P98194,Q9H6R6,Q53H12,P43307,Q9UNL2,Q99442,P40855,Q4J6C6,Q5BJH7,Q15629,Q15904,Q9Y512,Q15070,Q9GZY8,O00560,O43765,Q9Y5J9,Q9H4A6,Q9UGP8,O14737,O43681,O60725,Q9Y276,P46379,Q96A33 36 +Electron transport chain 0.4825863075065552 2.7780758839184436 0.0054681846285873 0.9999999999999996 0.4023262686809655 71 Q9P0J0,P04062,Q9UDW1,Q9Y6N1,O14949,Q7KZN9,P13073,O95169,P14927,P16435,P21912,O96000,Q9UJS0,P20674,Q9Y6M9,O43819,P00403,P09622,Q9H3K2,O95168 20 +Protein insertion into membrane 0.6006825875152725 2.7773767860395564 0.0054799612666938 0.9999999999999996 0.4023262686809655 28 O14737,Q8N4V1,O43681,Q53H12,Q15070,Q9NS69,Q9P0J0,Q9Y276,Q9NPA0,P46379,Q9Y5J9,Q15629,Q96A33,Q9Y512 14 +Monovalent inorganic cation homeostasis 0.5838364500039932 2.7570553513585563 0.005832447763171 1.0 0.4023262686809655 30 P05026,O75503,Q9Y487,P0CG08,P04899,Q05086,P27361,Q92544,P05023,P50897,Q9Y5X3,P06576,P54709,O75787,P51790,Q93050,Q9Y6M7,Q15904 18 +Glycosphingolipid metabolic process 0.8416649833917746 2.7478986975664252 0.0059978537239049 1.0 0.4023262686809655 9 P06280,P17900,Q99805,P16278,Q9NZD2,P06865 6 +Cristae formation 0.8151125401929357 2.7383016996499445 0.0061757391994858 1.0 0.4023262686809655 10 Q96E52,Q6UXV4,Q5XKP0,Q9BUR5,Q16891,O95202,Q9NX63,Q9NVH1,Q9Y512 9 +Metal ion homeostasis 0.4898926330141867 2.7225088365253063 0.0064788300753353 1.0 0.4023262686809655 82 Q8N668,Q9Y487,O75027,P20020,Q9UM00,Q04656,Q9HD20,O75880,P55011,Q9Y6N1,O95202,P05026,P16615,P98194,P02792,P30519,P23634,Q8TAD4,Q9H3K6,O60826,Q15904,P04899,Q9Y4W6,P05023,Q15043,Q6P4Q7,Q16891,P51572,Q96TC7,P35670,O43819,Q9BPX6,Q8NE86,P07686,Q9Y5X3,Q9UJZ1,P09601,P54709,O76024,Q96HE7,P02786,Q8WWC4,Q96A33,Q8IYU8 44 +Glycosyl compound catabolic process 0.8105521012077351 2.7158867359865844 0.006609852688838 1.0 0.4023262686809655 10 P06280,Q9NUJ1,Q9BTY2,P36639,P00813,P04062,P04066 7 +Amino acid transmembrane transport 0.7316641010706004 2.712489178753096 0.0066779961746343 1.0 0.4023262686809655 14 P08195,O60831,O75746,Q9H9B4,P30825,Q15758,P05556,Q96NB2,Q9UJS0,Q15041,O75915,Q8TDW0 12 +Hormone metabolic process 0.5975072127914811 2.704012652850014 0.0068507680464049 1.0 0.4023262686809655 27 Q8NBN7,P05023,P16435,O95470,Q9HB40,Q8TAD4,P30536,O75844,P42892,Q53GQ0 10 +Nucleotide transport 0.7645821401440516 2.6955883634302995 0.0070264438482867 1.0 0.4023262686809655 12 P12236,P41440,P12235,Q6NUK1,Q8TB61,Q9H2D1,Q08722,Q9HC21,O43808,Q8TDW0 10 +Inorganic anion transport 0.6135568554132177 2.6860972810844177 0.0072292037359844 1.0 0.4023262686809655 24 P08183,Q9NW15,O43681,Q4KMQ2,P45880,Q15043,Q9UHG3,Q9Y277,Q9UBX3,P30536,P51790,P21796,Q9Y6M7,Q8TDW0 14 +Protein transmembrane import into intracellular organelle 0.762407053427359 2.6841138602471823 0.0072722334986352 1.0 0.4023262686809655 12 Q15388,O75381,O95831,Q3ZCQ8,O96008,O14925,O60830 7 +Phospholipid metabolic process 0.4767924818203196 2.6776869139646693 0.0074132477051034 1.0 0.4023262686809655 74 Q9UG56,Q9NPH0,Q9NTJ5,O95749,Q99623,Q92643,Q86YN1,O15269,Q96N66,Q8NF37,Q9BVG9,Q10713,Q9NX62,Q8NHP8,P35790,O95674,Q9NZC3,P37268,Q8WTV0,Q5H8A4,Q8NCC3 21 +Regulation of steroid biosynthetic process 0.7776963273478036 2.6752347768053077 0.0074676934171697 1.0 0.4023262686809655 11 Q13510,P05023,P16435,O94905,P30536,Q12770 6 +Glycerophospholipid metabolic process 0.5029699911578783 2.668756235709042 0.0076132682131213 1.0 0.4023262686809655 54 Q96N66,Q8NF37,O95674,P35790,Q8WTV0,Q9UG56,Q5H8A4,Q9NPH0,Q9NZC3,Q9NTJ5,Q9BVG9,Q99623,Q92643,Q10713,Q9NX62,Q8NCC3 16 +Regulation of steroid metabolic process 0.7211283155881724 2.653320019370038 0.0079704264057109 1.0 0.4023262686809655 14 Q13510,P05023,P16435,O94905,P30536,Q12770 6 +Endoplasmic reticulum tubular network organization 0.7722025510711524 2.6469807285232094 0.0081213981081327 1.0 0.4023262686809655 11 Q9NQC3,P57088,Q8NHH9,O95197,Q15041,Q9H6H4 6 +Pigment metabolic process 0.5749957055733336 2.634501941071961 0.0084260822026347 1.0 0.4023262686809655 29 P22830,O75027,P30519,Q04656,P00813,P09601,P30536,Q7KZN9,O00264 9 +Ion transmembrane transport 0.5532124337459512 2.6274746207635347 0.0086021258390223 1.0 0.4023262686809655 156 Q8N668,P41440,Q8N4V1,Q9H9B4,Q9H2D1,Q9UDW1,Q9UHG3,Q9Y277,O43808,P21796,Q14728,O75964,Q8TDW0,P13073,P24539,O60831,P45880,P00846,Q9H0U3,Q9BVC6,P20674,P12235,Q9Y4W6,P30825,P05556,Q9UBX3,O75844,P00403,P12236,Q13423,Q96HE7,Q4KMQ2,O75915,Q8IYU8,P0CG08,O75027,Q99623,Q9HD20,Q7KZN9,P05026,O75947,P16615,P08195,Q70HW3,Q96NB2,Q8TAD4,P08183,Q8TB61,P05023,P05141,P36543,Q15758,O00483,Q14847,P54709,Q9UJZ1,Q8WWC4,Q13546,Q9NW15,Q96GC9,Q15041,O95202,P98194,O43772,Q9BQT8,Q9UJS0,Q15043,P35670,P56385,Q9BPX6,Q6P4A7,Q9HC21,P51790,P20020,Q9UM00,Q04656,O75746,P23634,P06576,Q6P4Q7,Q8NE86,Q9Y6M7 82 +Glycosylation 0.5220011577537279 2.6165272901951937 0.0088829263241481 1.0 0.4023262686809655 46 Q9BT22,Q9H9S5,O15118,P46977,P04062,Q16706,Q86YN1,Q96L58,Q10472,Q96JB2,Q11206,O75503,Q9H0U3,P83436,O60476,Q9BV10,O43505,P04843,Q9H6U8 19 +Cellular ion homeostasis 0.4896212906315408 2.6012700614128934 0.0092879305500794 1.0 0.4023262686809655 92 Q9Y487,O75027,P20020,Q9UM00,Q04656,Q9HD20,O75880,O95202,P16615,P98194,P02792,P50897,P23634,Q8TAD4,Q9H3K6,Q15904,O75503,Q9Y4W6,P05023,Q15043,P06576,Q16891,P51572,Q96TC7,P35670,Q93050,O43819,Q9BPX6,Q8NE86,P07686,Q05086,Q92544,P09601,O76024,Q96HE7,P51790,O75787,P02786,Q9Y6M7,Q96A33,Q8IYU8 41 +Endoplasmic reticulum to golgi vesicle mediated transport 0.4652400074090663 2.6009716863728825 0.0092960125955048 1.0 0.4023262686809655 70 Q9UBV8,Q15363,Q96PC5,P61019,Q9P2W9,Q9Y3A6,Q13190,Q12770,Q5JRA6,Q9BSR8,Q969X5,Q8NHH9,Q9NR31,Q12907,Q5BJH7,Q7Z7H5,P49257,Q96JB2,P24390,Q9H0U4,O95249,P51572,Q9Y282,P49755,O95070,Q9BVK6,O75396,Q9Y3B3 28 +Er nucleus signaling pathway 0.711720610741722 2.600120178844145 0.0093191117863704 1.0 0.4023262686809655 14 P16615,P57088,Q15363,O75477,Q9UM00,O94905,O76024,Q96A33,Q12770 9 +Mitochondrial fusion 0.6796100860116173 2.5969609936991542 0.0094052603989445 1.0 0.4023262686809655 16 Q96E52,Q9Y6C9,Q9Y4W6,Q9H6R6,Q9H300,Q9GZY8,O60313,O95140,P02786,Q8N2A8,Q9NX63 11 +Regulation of hormone levels 0.4729915407266759 2.5860696531611698 0.0097077310855671 1.0 0.4023262686809655 60 Q53GQ0,Q8NBN7,P05023,P16435,Q15043,O75844,O95470,Q9HB40,Q8TAD4,P30536,Q15907,Q8N5M9,P42892,P50416 14 +Vitamin transport 0.8257744056008964 2.5632279740966735 0.0103703929990568 1.0 0.4023262686809655 8 Q8WTV0,Q9H2D1,P04062,Q9HC21,P38435,Q9NY64 6 +Dicarboxylic acid transport 0.6449056465517852 2.553777866513862 0.0106561215084053 1.0 0.4023262686809655 18 Q9H936,P41440,O60831,Q9BQT8,O75746,Q9H2D1,Q15758,P05556,Q02978,Q9UBX3,Q9UJS0,Q15041,O75915,Q8TDW0 14 +Inorganic ion transmembrane transport 0.508498187427318 2.54999711995652 0.0107723808980431 1.0 0.4023262686809655 115 Q8N668,Q9H936,O75027,Q8N4V1,P20020,Q96GC9,Q9UM00,Q04656,Q02978,Q9UDW1,Q9UHG3,Q99623,Q9HD20,Q7KZN9,P21796,O95202,O75964,P05026,P13073,O75947,P16615,P24539,P98194,P08195,P23634,Q8TAD4,P00846,Q9H0U3,P20674,P12235,Q9Y4W6,P05023,Q15043,P06576,P05556,Q6P4Q7,Q9UBX3,P35670,P05141,P56385,P00403,Q9BPX6,Q8NE86,P36543,Q13423,O00483,P54709,Q9Y6M7,Q96HE7,P51790,Q4KMQ2,Q9UJZ1,Q8WWC4,Q8IYU8 54 +Nuclear envelope organization 0.5415098490081477 2.5471110784472644 0.0108618852884021 1.0 0.4023262686809655 33 P20700,Q8IXJ6,O75844,Q86XL3,O94901,Q9Y3E7,O14657,Q9Y2U8,P02545,Q9UH99,Q9BTV4,Q8NC56,Q9H6H4,Q8N1F7,P50402,Q9UQN3,Q9ULX6 17 +Cellular monovalent inorganic cation homeostasis 0.5745336732184292 2.532368347294952 0.0113294905759764 1.0 0.4023262686809655 27 P05026,O75503,Q9Y487,P0CG08,Q05086,P27361,Q92544,P05023,P50897,P06576,P54709,O75787,P51790,Q93050,Q9Y6M7,Q15904 16 +Metal ion export 0.7489767171948019 2.5264256079441556 0.0115229789699717 1.0 0.4023262686809655 11 P05026,P20020,P05023,Q04656,P23634,P35670,Q4KMQ2,O95202 8 +Glycoside catabolic process 0.8882466281310177 2.521894678413271 0.0116724650711264 1.0 0.4023262686809655 6 P06280,Q9NUJ1,Q9BTY2,P04062,P04066 5 +Proteoglycan metabolic process 0.856967195530996 2.5135969951579575 0.0119506910184141 1.0 0.4023262686809655 7 Q8NCH0,Q7LGA3,Q99805,Q9NX62 4 +Lipid localization 0.4569101375834584 2.508565599145219 0.0121222457525238 1.0 0.4023262686809655 70 P08183,Q99720,P35790,O43772,Q14108,Q9BUR5,P17900,Q14534,Q8WTV0,Q96GC9,Q9H6V9,O15118,P04062,Q9NZJ7,Q9NZD2,P23786,O15260,P50416 18 +Cation transmembrane transport 0.5123244031824196 2.5071807763877576 0.0121698452662111 1.0 0.4023262686809655 123 Q8N668,Q9NW15,O75027,Q8N4V1,Q9H9B4,P20020,Q96GC9,Q9UM00,Q04656,Q9UDW1,Q99623,Q9HD20,Q7KZN9,P21796,O95202,O75964,P05026,P13073,O75947,P16615,P24539,P98194,O43772,P08195,Q70HW3,Q96NB2,P23634,Q8TAD4,P00846,Q9H0U3,P20674,P12235,Q9Y4W6,P05023,P30825,Q15043,P06576,P05556,Q6P4Q7,P35670,P05141,P56385,P00403,Q9BPX6,Q8NE86,P36543,Q13423,Q15758,O00483,P54709,Q9HC21,Q9Y6M7,Q96HE7,P51790,Q4KMQ2,Q9UJZ1,Q8WWC4,Q8IYU8 58 +Protein import into mitochondrial matrix 0.8127573285605809 2.50209373939112 0.0123461230828143 1.0 0.4023262686809655 8 Q15388,Q3ZCQ8,O96008,O14925,O60830 5 +L amino acid transport 0.7282913848466374 2.50197636349784 0.0123502169927955 1.0 0.4023262686809655 12 P08195,O60831,O75746,Q9H9B4,P30825,Q15758,P05556,Q9UJS0,Q15041,O75915 10 +Cellular hormone metabolic process 0.6636350005449924 2.5002322113344593 0.0124111924739784 1.0 0.4023262686809655 16 Q8NBN7,O95470,Q9HB40,P30536,P42892,Q53GQ0 6 +Protein processing 0.5104200448903247 2.486853296478757 0.0128878532407323 1.0 0.4023262686809655 45 Q92896,O75503,Q96E52,Q9UG56,Q9BXI6,Q9H300,Q92542,Q8TCT9,O75976,Q15005,Q8TAD4,Q10713,O75844,Q5JRX3,P42892 15 +Phospholipid transport 0.6916376771134143 2.485381040766723 0.0129412831575332 1.0 0.4023262686809655 14 P08183,Q14108,Q8WTV0,Q9NZD2 4 +Amino acid transport 0.6054453756339087 2.4851460146747018 0.0129498306485882 1.0 0.4023262686809655 20 Q9H936,Q6P4A7,P08195,Q9H9B4,O60831,O75746,P30825,Q96NB2,P05556,Q15758,Q9UJS0,Q15041,O75915,Q8TDW0 14 +Respiratory chain complex iv assembly 0.850472097086819 2.484535808526337 0.0129720461075877 1.0 0.4023262686809655 7 Q15070,Q9Y276,Q9Y2R0,Q7KZN9,O43819 5 +Mucopolysaccharide metabolic process 0.7636320553601685 2.4815700243704004 0.0130805006796712 1.0 0.4023262686809655 10 O43505,P16278,P15586,Q9NX62,Q8NCH0,Q11206 6 +Purine nucleotide transport 0.7620836190338521 2.473720389180592 0.0133714302734135 1.0 0.4023262686809655 10 P12236,P41440,P12235,Q6NUK1,Q8TB61,Q08722,O43808,Q8TDW0 8 +Establishment of protein localization to mitochondrial membrane 0.6718804365676786 2.472861294021342 0.0134036154086099 1.0 0.4023262686809655 15 Q53H12,Q15070,Q9Y276,Q9NS69,Q9P0J0,Q9Y5J9,Q9Y512 7 +Phospholipid biosynthetic process 0.4830238174544848 2.4710797085544227 0.0134705790095501 1.0 0.4023262686809655 54 Q9UG56,Q9NPH0,Q9NTJ5,O95749,Q92643,Q86YN1,O15269,Q96N66,Q8NF37,Q9BVG9,Q96S52,Q10713,Q9NX62,Q9NUQ2,O95674,P35790,O00459,P07686,Q5H8A4,Q96PE3 20 +Transmembrane transport 0.5781629114840623 2.469677779825461 0.0135234802996664 1.0 0.4023262686809655 208 Q8N668,P41440,Q8N4V1,Q9H9B4,Q9H2D1,Q9NS69,Q9UDW1,Q9UHG3,Q9Y277,O43808,P21796,Q14728,O43615,O60830,O75298,O75964,Q8TDW0,P13073,P24539,O60831,P45880,O14925,P00846,Q9H0U3,Q9BVC6,P20674,P12235,Q9Y4W6,P30825,P05556,Q9UBX3,O75844,P00403,P12236,Q8WTV0,Q13423,Q96HE7,Q4KMQ2,O75915,Q8IYU8,P0CG08,O75027,Q99623,Q9HD20,Q7KZN9,P23786,P31751,P50416,P05026,O75947,P16615,P08195,Q70HW3,Q8TAD4,Q9NY64,P08183,Q8TB61,P05023,P49755,Q07820,P38435,Q9NW15,Q96GC9,Q16625,P04062,Q15041,O95202,P98194,O43772,Q9BQT8,Q8IXU6,Q9UJS0,Q15629,P52789,Q15043,O95831,L0R6Q1,P35670,P56385,Q9BPX6,Q15388,Q6P4A7,Q9HC21,P51790,Q6NUK1,O75381,P20020,Q9UM00,Q04656,Q3ZCQ8,O75746,Q99442,P23634,P06576,Q6P4Q7,Q9UGP8,Q8NE86,O96008,Q9Y6M7 99 +Signal peptide processing 0.9081370775863332 2.46295179129942 0.0137798442468717 1.0 0.4023262686809655 5 O75503,Q15005,Q8TCT9 3 +Regulation of lipid biosynthetic process 0.5695149677451652 2.449848616741249 0.0142916286711589 1.0 0.4023262686809655 26 Q8NF37,Q8WTV0,Q13510,P05023,P16435,O94905,P30536,Q12770 8 +Sterol metabolic process 0.5213451133707167 2.4324307842165256 0.0149978577316578 1.0 0.4023262686809655 37 Q8WTV0,P04035,Q14534,P38571,P16435,O15118,Q16850,Q15800,O94905,P04062,Q15392,P37268,Q12770,O75845 14 +Protein targeting 0.5003322385623821 2.417990197716773 0.015606497224845 1.0 0.4023262686809655 119 Q8N4H5,O75381,Q9H300,Q9NS69,Q9P0J0,Q3ZCQ8,Q15041,O60830,Q14108,Q9H6R6,Q53H12,P43307,Q9UNL2,Q99442,P40855,Q10713,Q5BJH7,Q15629,O14925,Q9Y512,Q9GZY8,O95831,Q9Y5M8,O00560,P55786,P51572,Q9BZL1,P30536,Q9Y5J9,P20645,Q9UGP8,Q15388,O14737,P13473,O43681,O60725,Q9Y371,Q15005,P46379,O95140,P57105,Q5JRX3 42 +Transition metal ion homeostasis 0.5589245538138636 2.41375510770715 0.0157890705338106 1.0 0.4023262686809655 27 Q8N668,Q9Y487,O75027,P30519,Q15043,Q04656,P09601,Q8TAD4,O75880,P35670,O43819,Q9H3K6,Q15904 13 +Regulation of cellular ph 0.5853402106421296 2.410648696206065 0.0159241786147568 1.0 0.4023262686809655 22 O75503,Q9Y487,Q05086,Q92544,P50897,P06576,O75787,P51790,Q93050,Q9Y6M7,Q15904 11 +Regulation of ph 0.5853402106421296 2.410648696206065 0.0159241786147568 1.0 0.4023262686809655 22 O75503,Q9Y487,Q05086,Q92544,P50897,P06576,O75787,P51790,Q93050,Q9Y6M7,Q15904 11 +Amide transport 0.5230926923446075 2.405568576839245 0.0161473210393345 1.0 0.4023262686809655 34 P08183,Q9H2D1,Q15907,Q8N5M9,Q9NZD2,P50416 6 +L alpha amino acid transmembrane transport 0.7258951853610334 2.4048184738197147 0.0161805008430455 1.0 0.4023262686809655 11 O60831,P08195,O75746,P30825,Q15758,P05556,Q9UJS0,Q15041,O75915 9 +Tetrapyrrole biosynthetic process 0.6897698498577512 2.379057571127711 0.0173569649037093 1.0 0.4023262686809655 13 P22830,O75027,P30536,Q7KZN9,O00264 5 +Aminoglycan catabolic process 0.8879614767255223 2.3778138686055836 0.0174156143905361 1.0 0.4023262686809655 5 P04066,P16278,P15586,P54802 4 +Glycosaminoglycan catabolic process 0.8879614767255223 2.3778138686055836 0.0174156143905361 1.0 0.4023262686809655 5 P04066,P16278,P15586,P54802 4 +Terpenoid metabolic process 0.6166296650512675 2.3710055123002167 0.017739766513501 1.0 0.4032502702737112 18 Q9BY49,Q8NBN7,P51648,O95749,Q9HB40,P37268 6 +Ceramide catabolic process 0.8251193603699124 2.370098410210325 0.0177833511845362 1.0 0.4032502702737112 7 P06280,P17900,P06865,Q13510 4 +Entry into host 0.5263892665162483 2.3536191209280175 0.0185916499213056 1.0 0.4041996473361619 31 Q14108,Q8WTV0,P07237,P06493,P08195,P35232,Q9BTY2,O15118,Q15758,P05556,Q9P253,P35613,Q14118,P11279,P02786,P78310 16 +Oligosaccharide lipid intermediate biosynthetic process 0.8789638272564201 2.3395745436273043 0.0193057184819396 1.0 0.4041996473361619 5 Q9BV10,Q86YN1,Q9BT22 3 +Cellular transition metal ion homeostasis 0.5696311952085451 2.3328243626557943 0.0196573654576215 1.0 0.4041996473361619 23 Q9Y487,O75027,Q15043,P09601,Q8TAD4,O75880,P35670,O43819,Q9H3K6,Q15904 10 +Aerobic respiration 0.4627545344110555 2.3273725887673495 0.0199454433773809 1.0 0.4041996473361619 90 Q9UDW1,O14949,Q7KZN9,O75964,P13073,P14406,P24539,O95169,P14927,P21912,O96000,P00846,P20674,Q15070,P22695,Q9Y6M9,P56385,P00403,P09622,Q13423,Q9H3K2,O95168 22 +Protein n linked glycosylation 0.621280967658028 2.3164957755235123 0.0205312148282372 1.0 0.4041996473361619 17 P04843,Q9BT22,Q9H6U8,P46977,Q86YN1,Q9BV10 6 +Proteoglycan biosynthetic process 0.8404813545477773 2.3132161093309698 0.0207107603015905 1.0 0.4041996473361619 6 Q8NCH0,Q7LGA3,Q99805 3 +Mitochondrial cytochrome c oxidase assembly 0.839755940912002 2.3100068076531777 0.0208877772338484 1.0 0.4041996473361619 6 Q15070,Q9Y276,O75880,Q9Y2R0,O43819 5 +Glycolipid catabolic process 0.8115378396826785 2.3081332106166057 0.0209917285357541 1.0 0.4041996473361619 7 P06280,P04066,P17900,P06865 4 +Mitochondrial electron transport ubiquinol to cytochrome c 0.8704638594735209 2.30329675841902 0.0212621519071658 1.0 0.4041996473361619 5 Q9UDW1,O14949 2 +Vitamin transmembrane transport 0.836544637122665 2.2957852069577034 0.0216881656781389 1.0 0.4041996473361619 6 Q8WTV0,Q9H2D1,P04062,Q9HC21,P38435 5 +Amino acid import 0.7480874533045592 2.292575010988804 0.0218724844207132 1.0 0.4041996473361619 9 Q9H9B4,P08195,P30825,Q96NB2,P05556,Q15041,O75915 7 +Nucleotide transmembrane transport 0.7679948586118224 2.2883120743756975 0.0221193538570283 1.0 0.4041996473361619 8 P12236,P41440,P12235,Q8TB61,Q9H2D1,O43808,Q8TDW0 7 +Export across plasma membrane 0.7461159913244458 2.282705017244823 0.0224477500578701 1.0 0.4041996473361619 9 P08183,P05026,P20020,P05023,P35670,Q4KMQ2 6 +Mitochondrial atp synthesis coupled proton transport 0.7021672758031839 2.2779003282800976 0.0227325167255465 1.0 0.4041996473361619 11 P56385,P24539,P00846,O75964 4 +Retrograde vesicle mediated transport golgi to endoplasmic reticulum 0.5285813179816444 2.269031083508998 0.0232664356924967 1.0 0.4044781102327139 29 P83436,Q969X5,Q9P2W9,O15258,Q9Y282,P49755,Q12907,Q9H4A6,Q8TD16,O75396,Q96JB2,Q12981,P24390 13 +Membrane protein proteolysis 0.6703911118919718 2.268883773056079 0.023275394767898 1.0 0.4044781102327139 13 Q9NZ08,P38159,Q9H300,Q92542,Q14118,Q16740,Q8TCT9 7 +Aminoglycan biosynthetic process 0.7432768068753348 2.268470348251464 0.0233005542921074 1.0 0.4044781102327139 9 O43505,Q7LGA3,Q8NCH0,P06865,Q11206 5 +Amyloid precursor protein metabolic process 0.6135505951736584 2.2669112603767942 0.0233956472111191 1.0 0.40476418902401 17 Q9NQC3,Q92542,Q15392,P49755,O95197,O75298 6 +Peptide catabolic process 0.7209495346482615 2.262401451112488 0.023672611362713 1.0 0.40476418902401 10 O14773,Q9NZ08,P55786,Q9UIQ6,P42892 5 +Ceramide biosynthetic process 0.7625819053577693 2.262082656234362 0.0236922969545785 1.0 0.40476418902401 8 P04062,Q53H12,Q13510 3 +Amyloid beta formation 0.6984899311841067 2.2580559067233357 0.023942174155459 1.0 0.405605130321144 11 O95197,O75298,Q92542,Q9NQC3 4 +Early endosome to golgi transport 0.7608669774433251 2.2537555619439873 0.0242115498224129 1.0 0.405605130321144 8 O60749,Q9BVK6,O60499,Q13190,O15260 5 +Diol metabolic process 0.7605194658474764 2.252067162546252 0.0243180280560839 1.0 0.405605130321144 8 O15269,P04062,Q13510 3 +Diol biosynthetic process 0.7605194658474764 2.252067162546252 0.0243180280560839 1.0 0.405605130321144 8 O15269,P04062,Q13510 3 +Alcohol metabolic process 0.4474700341369373 2.2518230962659636 0.0243334535263017 1.0 0.405605130321144 82 Q9Y394,O15118,P04062,Q15392,O15269,Q12770,Q13510,Q14534,P04035,Q8NBN7,P51648,P16435,Q10713,Q9NX62,P00374,Q9BY49,P30837,Q9NZC3,O94905,P37268,O75845,Q8WTV0,Q16850,Q15800 24 +Purine containing compound transmembrane transport 0.7587835997928828 2.2436283194177102 0.0248563255918869 1.0 0.4095615881790111 8 P12236,P41440,P12235,Q8TB61,O43808,Q8TDW0 6 +Iron ion transport 0.6944081999880666 2.23597408751579 0.0253534685867684 1.0 0.4129411103527159 11 O75027,Q8N4V1,Q9H9B4,P02792,Q15043,Q04656,Q15907 7 +Bone morphogenesis 0.7953740521614658 2.2337811422860026 0.0254974769310196 1.0 0.4129411103527159 7 O75844,P16435,Q9NX62 3 +Steroid biosynthetic process 0.485377436928204 2.233463617131539 0.0255183870089086 1.0 0.4129411103527159 44 Q53GQ0,Q13510,Q14534,P04035,P05023,P16435,Q16850,Q15800,O94905,Q15392,P30536,P37268,Q12770,O75845 14 +Mannosylation 0.756464966109408 2.2323432008230455 0.0255922886946022 1.0 0.4129411103527159 8 O43505,Q9BV10,Q9BT22 3 +Receptor recycling 0.7948346668047639 2.2312886384099437 0.0256620157818054 1.0 0.4129411103527159 7 Q15907 1 +Mitochondrion organization 0.5441542905383667 2.2287282175259313 0.0258319935868494 1.0 0.4129411103527159 191 Q8N4H5,Q96A26,Q9NS69,Q9Y2R0,Q69YU5,P21796,O43615,O60830,Q9NVH1,P14406,P35232,P45880,Q96CU9,Q13505,P02545,Q10713,O14925,Q9H061,P12235,O75306,Q15070,Q9Y6M9,Q9UDX5,Q5XKP0,Q9P0J0,Q99623,Q9BUR5,Q9BWH2,Q86Y39,Q53H12,O96000,Q6UXV4,O60313,P55786,Q16891,Q9H4A6,O43819,Q8IUX1,Q96E52,Q9Y6C9,Q9NVI7,Q9Y276,O75153,Q5JRX3,Q9UG56,Q9H300,P04062,O75880,O95202,Q5T9A4,O95169,Q9H6R6,P78310,Q9Y512,P52789,Q9GZY8,O95831,P51572,P30536,Q15388,O75431,Q9Y371,Q9H3K2,O95168,Q6DKK2,Q04656,Q3ZCQ8,Q8N2A8,Q9NX63,Q9BZL1,Q9Y5J9,Q9NX14,Q8NE86,O14737,Q9BUB7,O95140,O96008,Q96I36 78 +Import into cell 0.5168832399228311 2.2230986396317527 0.0262091493691321 1.0 0.4129411103527159 30 P05026,P41440,P08195,P05023,P30825,Q15043,Q15758,P05556,P23634,P54709,Q15041,O75955,O75915,P31751,Q8TDW0 15 +Vascular transport 0.6463939833582182 2.220912860258834 0.0263568640219287 1.0 0.4129411103527159 14 P08183,P41440,P30825,Q15758,P23634,P55011,P02786 7 +Glycolipid biosynthetic process 0.7525492163785812 2.2132504652691107 0.0268803826178005 1.0 0.4129411103527159 8 Q99805,Q8NBX0,Q5H8A4,Q92643,Q11206 5 +Ion homeostasis 0.4730841683935198 2.21283111515295 0.026909291245208 1.0 0.4129411103527159 110 Q8N668,Q9Y487,O75027,P20020,Q9UM00,Q04656,Q9HD20,O75880,Q9Y6N1,O95202,P16615,P98194,P02792,P30519,P50897,P23634,Q8TAD4,Q9H3K6,Q15904,O75503,Q9Y4W6,P05023,Q15043,P06576,Q6P4Q7,Q16891,P51572,Q96TC7,P30536,P35670,Q93050,O43819,Q9BPX6,Q8NE86,P07686,Q05086,Q92544,Q9Y5X3,P09601,O76024,Q96HE7,P51790,O75787,P02786,Q9Y6M7,Q96A33,Q8IYU8 47 +Atp synthesis coupled proton transport 0.6754021619518396 2.2113587689475476 0.0270110026510113 1.0 0.4129411103527159 12 P56385,P24539,P00846,O75964 4 +Keratan sulfate metabolic process 0.9220154043645644 2.194716131410583 0.0281839668428398 1.0 0.4129411103527159 4 O43505,P16278,Q11206 3 +Amyloid beta metabolic process 0.6574178170905748 2.19431171289537 0.0282130079776476 1.0 0.4129411103527159 13 O95197,O75298,Q92542,Q9NQC3 4 +C4 dicarboxylate transport 0.7483933161953629 2.1929397296377746 0.0283117217672659 1.0 0.4129411103527159 8 Q9H936,O75746,Q15758,Q02978,Q9UBX3,Q9UJS0,Q8TDW0 7 +Endoplasmic reticulum calcium ion homeostasis 0.7463959277177792 2.1831608366243076 0.029023967716186 1.0 0.4176720603135808 8 P16615,P51572,O76024,Q96A33 4 +Tetrapyrrole catabolic process 0.9168456321208238 2.173695721276686 0.0297279942150483 1.0 0.4241629416353711 4 P30519 1 +Positive regulation of blood circulation 0.8375907967089427 2.161591975024487 0.0306496405723804 1.0 0.4241917890712444 5 P16615,P00813 2 +Phosphatidylcholine metabolic process 0.6511898190023526 2.158278973127796 0.0309061485259856 1.0 0.4241917890712444 13 Q8NF37,P35790,Q8NCC3,Q8WTV0 4 +Amyloid precursor protein catabolic process 0.6351070011984028 2.1536225321699964 0.0312697857784676 1.0 0.4273756826817089 14 Q9NQC3,Q92542,Q15392,P49755,O95197,O75298 6 +Endochondral bone morphogenesis 0.8346857266505896 2.1489623315243893 0.0316373860576257 1.0 0.4296860047826498 5 O75844,Q9NX62 2 +Sulfur compound transport 0.7382378250604131 2.1431037978758187 0.0321047645785881 1.0 0.434142264379379 8 Q8TB61,Q70HW3,Q9H0H5,Q9HC21,Q9UBX3,Q8TDW0 6 +Calcium ion import 0.6330140494365315 2.1410867290957167 0.032267044675309 1.0 0.434142264379379 14 P16615,Q9BPX6,Q9Y4W6,P23634,P21796,O75844,Q8NE86 7 +Protein localization to extracellular region 0.4379225584177421 2.135345070624467 0.032732833942948 1.0 0.4342977463489089 58 Q5JRA6,P27824,Q96KC8,P04035,Q32P28,Q96PC5,P61026,Q16850,Q9UBV2,P49755,Q9H4A6,Q15907,P20645,Q8N5M9,Q8NE86,P50416 16 +Sphingoid metabolic process 0.8312086218992651 2.133823096035982 0.0328572645550917 1.0 0.4342977463489089 5 O15269,P04062,Q13510 3 +Iron ion homeostasis 0.5920676280968591 2.12759032776205 0.0333710648660778 1.0 0.4347935752935511 17 Q9Y487,O75027,P30519,P09601,Q9H3K6,Q15904 6 +Cytoplasmic pattern recognition receptor signaling pathway in response to virus 0.6603453057363746 2.126748487247179 0.0334409864574762 1.0 0.4347935752935511 12 Q99623,O43657 2 +Oligosaccharide metabolic process 0.7985781516844446 2.125855299949315 0.0335153098091958 1.0 0.4347935752935511 6 P06280,P17900,Q11206 3 +Protein localization to endoplasmic reticulum 0.4887089033611482 2.1208107492550345 0.0339377317482234 1.0 0.4347935752935511 35 Q5JRA6,O43681,Q9NQC3,P61026,Q96HY6,Q9UNL2,Q99442,Q9Y5M8,O43765,P51572,Q15005,P46379,Q15629,Q9UGP8,P24390 15 +Response to increased oxygen levels 0.7329879235260053 2.1172275176504076 0.0342405430441195 1.0 0.4347935752935511 8 Q9Y487,P00846 2 +Protein maturation 0.4202267437948585 2.1169148684683474 0.0342670735485393 1.0 0.4347935752935511 68 Q92896,Q9H9S5,Q9UG56,Q9BXI6,Q9BU89,Q9H300,O75976,Q15392,Q96TA2,Q92542,Q8TAD4,Q10713,Q9H3K6,O75503,O43464,Q9Y4W6,P35670,O75844,Q9BU23,P42892,Q96E52,Q15005,O76024,Q96HE7,O75787,Q8TCT9,Q5JRX3 27 +Respiratory chain complex iii assembly 0.8267681163533596 2.1144533421791554 0.0344765658072627 1.0 0.4347935752935511 5 Q9Y276,Q69YU5 2 +Regulation of cholesterol biosynthetic process 0.826581579383588 2.113638776896188 0.0345461312511481 1.0 0.4347935752935511 5 O94905,P16435,Q12770 3 +Regulation of alcohol biosynthetic process 0.826581579383588 2.113638776896188 0.0345461312511481 1.0 0.4347935752935511 5 O94905,P16435,Q12770 3 +Regulation of vacuole organization 0.6271311496035026 2.1057534242973404 0.0352257765109309 1.0 0.43936828337132 14 Q14108,Q9H0U4,Q9UHD9,Q9Y371,Q13099,O75396 6 +O glycan processing 0.8236066113689064 2.1006381852374 0.0356727393680338 1.0 0.4428057819833186 5 O43505,Q10472 2 +Protein exit from endoplasmic reticulum 0.5464099603473536 2.0995473962860633 0.0357686743291494 1.0 0.4431493010397673 21 Q96CS3,Q9Y679,Q92544,Q9BVK6,Q9NR31,Q8TCT9,Q9UBV2,P51572,Q9BUN8,P49257,O15260 11 +Folic acid metabolic process 0.7291703142068082 2.0983623262348408 0.0358731506299003 1.0 0.4433660267229183 8 Q9H2D1,Q8IYS1,P00374 3 +Mitochondrial calcium ion transmembrane transport 0.689006751548221 2.0945419314217 0.0362117318478105 1.0 0.4436210311567649 10 Q9BPX6,Q9Y4W6,Q8IYU8,O95202,Q9UJZ1,P21796,Q8WWC4,Q8NE86 8 +Cellular respiration 0.4585814704498322 2.0936334923901887 0.036292641640842 1.0 0.4437134266145882 106 Q04656,Q9NZ45,P04062,Q9UDW1,O14949,Q7KZN9,O75964,P13073,P14406,P24539,O95169,P14927,P21912,O96000,Q9UJS0,P00846,P20674,Q15070,P22695,Q9Y6M9,O43819,P56385,P00403,P09622,Q13423,Q9H3K2,O95168 27 +Vacuolar acidification 0.7074289810323028 2.086656284303708 0.0369192155766138 1.0 0.4488381039763612 9 O75503,Q93050,P50897 3 +Cell recognition 0.543037925079149 2.0750578257142056 0.0379811758126238 1.0 0.4591690751872512 21 P45880,Q8WTV0,Q9NQC3 3 +Atp biosynthetic process 0.546504706546101 2.0720704490459942 0.0382588717240468 1.0 0.4599679091666934 20 P24539,O75746,Q9UJS0,P00403,P56385,P00846,O75964 7 +Phosphatidylglycerol metabolic process 0.7230535795440637 2.0680505863945977 0.0386352665270315 1.0 0.4619155622347858 8 Q8NCC3,Q8NF37,Q99623 3 +Cartilage development 0.581279751574037 2.0567799030729796 0.0397074020818144 1.0 0.4653076792692047 17 Q92896,P16435,Q15043,Q04656,Q9NX62,O75844 6 +Response to food 0.7813729986049127 2.047763961183844 0.0405831331940391 1.0 0.4677248237444406 6 P80303 1 +Mammary gland development 0.5351569824282696 2.047025478353931 0.0406555830008588 1.0 0.4677248237444406 22 Q9NQC3,P52789,Q99623,Q13505,P35670,P00403 6 +Organelle membrane fusion 0.4824039513435487 2.044012256227883 0.0409523363717239 1.0 0.4677248237444406 33 Q9BZG1,Q9BSR8,O15400,Q9Y3E7,O95721,O60499,O43752,O95249,Q12846,Q12981,O75396,Q13190,Q9UQN3,P31751 14 +L glutamate transmembrane transport 0.7545775778991228 2.04318298150691 0.0410343277921692 1.0 0.4677248237444406 7 O60831,O75746,P05556,Q9UJS0,Q15041,O75915 6 +Heparan sulfate proteoglycan biosynthetic process 0.8103742028278623 2.0425952898914557 0.0410925177637016 1.0 0.4677248237444406 5 Q7LGA3,Q99805 2 +Heparan sulfate proteoglycan metabolic process 0.8103742028278623 2.0425952898914557 0.0410925177637016 1.0 0.4677248237444406 5 Q7LGA3,Q99805 2 +Membrane protein ectodomain proteolysis 0.6790765806485802 2.041685086925807 0.0411827790004213 1.0 0.4677248237444406 10 Q8TCT9,Q92542,Q14118,Q9NZ08 4 +Neutral lipid metabolic process 0.6161690040537164 2.0395299580254114 0.0413971644464592 1.0 0.4677248237444406 14 Q96N66,Q8WTV0,Q9UBV2,Q8NCC3,P50416 5 +Iron ion transmembrane transport 0.8096104464137965 2.039234350615511 0.0414266441240069 1.0 0.4677248237444406 5 Q15043,O75027,Q8N4V1 3 +Circulatory system process 0.4201376553358007 2.037996758640956 0.0415502570320442 1.0 0.4683060219653325 74 P08183,P16615,Q9UIQ6,Q9NZ08,P20020,P05023,Q9Y5X3,Q16625,P30825,P42785,P00813,P10253,Q6PI78,Q9HB40,P09601,P78310,O75844,P42892 18 +Inorganic anion transmembrane transport 0.7161725435994227 2.033826222688612 0.0419691196393372 1.0 0.4690657667715016 8 Q02978,Q9UBX3,Q9UHG3,P51790,Q4KMQ2 5 +Sensory perception of light stimulus 0.6151736518706239 2.0334922151275676 0.0420028192870334 1.0 0.4690657667715016 14 Q9H6K4,P50897,O43924,O60313 4 +Antiviral innate immune response 0.8080019130606199 2.032152107247017 0.0421382596353845 1.0 0.4690657667715016 5 Q99623,Q9NVI7 2 +Regulation of cholesterol metabolic process 0.7778696240453895 2.031780402121197 0.0421758920625259 1.0 0.4690657667715016 6 O94905,P16435,Q12770 3 +Negative regulation of blood pressure 0.8819830390941723 2.030788854020405 0.0422764181846377 1.0 0.4690657667715016 4 Q9HB40,P42785 2 +Ph reduction 0.6289736255207452 2.0285083722070443 0.0425083897029499 1.0 0.4701268585205294 13 O75503,Q9Y487,Q05086,P50897,P51790,Q93050 6 +Collagen biosynthetic process 0.8805788930048617 2.0249915537775585 0.0428682315233914 1.0 0.4708977310488282 4 P08670 1 +Copper ion homeostasis 0.7761721258830949 2.0240258796312163 0.0429674890201123 1.0 0.4709312059935325 6 Q8N668,Q04656,O75880,P35670,O43819 5 +Organophosphate catabolic process 0.4761023843873754 2.020639545704487 0.0433170921166008 1.0 0.4709312059935325 36 Q8WTV0,Q9NZC3,P00813,Q10713,Q9NX62,Q8NCC3,Q8NHP8 7 +Sterol biosynthetic process 0.5134191415137929 2.0187359738360735 0.0435146688672649 1.0 0.4709312059935325 26 Q14739,P04035,Q14534,O75477,P16435,Q15738,Q16850,Q15800,O94905,P14324,Q15392,P37268,P00387,Q12770,O75845 15 +Cerebellar purkinje cell layer development 0.6940899798006679 2.0180159680615835 0.0435895983293763 1.0 0.4709312059935325 9 P04062,P54802,O14949 3 +Negative regulation of amyloid precursor protein catabolic process 0.6931550777678992 2.013185101352726 0.0440951600054448 1.0 0.4709312059935325 9 O95197,O75298,Q9NQC3 3 +Pigment biosynthetic process 0.5160058565343035 2.001717496297964 0.0453151235770925 1.0 0.4712266584275738 25 P22830,O75027,P00813,Q04656,P30536,Q7KZN9,O00264 7 +Regulation of oxidoreductase activity 0.5832127403724837 1.995646197801905 0.0459724471944011 1.0 0.4712266584275738 16 P06280,Q8WTV0,P16435,Q15070,Q04656,Q99623,P00374,Q8TCT9 8 +Positive regulation of mitochondrial translation 0.6895655416177728 1.994612801101203 0.0460851263380774 1.0 0.4712266584275738 9 Q567V2 1 +Embryonic digit morphogenesis 0.7435309742447027 1.9908514159789217 0.0464972248068542 1.0 0.4712266584275738 7 Q9NX62 1 +Triglyceride metabolic process 0.6693936165039422 1.9898371031596505 0.0466088827674551 1.0 0.4713159920970695 10 Q96N66,Q8WTV0,Q9UBV2,P50416 4 +Ceramide transport 0.7974998819238606 1.9857854022393264 0.0470571573401787 1.0 0.4729393572839139 5 P08183,Q9NZD2 2 +Regulation of pattern recognition receptor signaling pathway 0.5923850301418829 1.985752457351936 0.0470608171296069 1.0 0.4729393572839139 15 O43657,Q9NQC3 2 +Macromolecule depalmitoylation 0.767564122646281 1.9846028985303856 0.0471886696118861 1.0 0.4730807205971016 6 Q9UMR5,P50897 2 +Atp transport 0.7675016056518896 1.9843159745467844 0.0472206264551635 1.0 0.4730807205971016 6 P12236,P12235,Q6NUK1,Q08722,O43808 5 +Isoprenoid metabolic process 0.5128734877491434 1.9773538822474912 0.0480016430292045 1.0 0.4779550100392571 25 Q9Y394,Q8NBN7,P51648,Q9BY49,O95749,Q9HB40,P37268 7 +Phosphatidylinositol biosynthetic process 0.5326202619039886 1.971865128343284 0.0486250050672467 1.0 0.4812096538057408 20 Q96N66,Q5H8A4,O00459,Q9NTJ5,Q92643,Q96S52,Q10713,Q9NX62 8 +Fat soluble vitamin metabolic process 0.7939218542631574 1.9699382874544955 0.0488454437157492 1.0 0.4819219158094898 5 P38435,Q8N0U8 2 +Regulation of release of cytochrome c from mitochondria 0.6452338357245959 1.965367009488134 0.0493717749631732 1.0 0.4842382866636067 11 O14737,Q96A26,Q9H300,Q9GZY8,O60313,Q9H3K2 6 +Neuron maturation 0.7928850771390035 1.9653416705263629 0.0493747056681739 1.0 0.4842382866636067 5 O75503 1 +Calcium import into the mitochondrion 0.7378734339864903 1.9639312957256845 0.0495380599569927 1.0 0.4842382866636067 7 Q9BPX6,Q9Y4W6,Q8IYU8,P21796,Q8WWC4,Q8NE86 6 +Mitochondrial calcium ion homeostasis 0.6446991816567894 1.9623783954794929 0.0497184461462232 1.0 0.4842382866636067 11 Q9BPX6,Q9Y4W6,Q8IYU8,O95202,P51572,Q16891,Q8WWC4,Q8NE86 8 +Negative regulation of steroid metabolic process 0.86489088575096 1.9600072315871304 0.0499949450608692 1.0 0.4842382866636067 4 O94905,P05023,Q12770 3 +Amino acid import across plasma membrane 0.7607578676942768 1.9533140870339931 0.0507823892834384 1.0 0.4842382866636067 6 P08195,P30825,P05556,Q15041,O75915 5 +Sphingosine biosynthetic process 0.86310176693732 1.9525715866254312 0.0508703807000276 1.0 0.4842382866636067 4 P04062,Q13510 2 +Neuromuscular process 0.5093249274107589 1.9496754266268128 0.0512148169971691 1.0 0.486534422757792 25 O14773,P17900,P04062,P07196,O75844 5 +Integrated stress response signaling 0.789267036269942 1.949284298592844 0.0512614826195825 1.0 0.486534422757792 5 P57088,Q96E52,Q15363 3 +Calcium ion export 0.8611033401456016 1.9442601707857377 0.0518640850511964 1.0 0.4892925775833914 4 P20020,O95202 2 +Regulation of anion transport 0.6412874555925605 1.943284138719266 0.0519818368611226 1.0 0.4892925775833914 11 P08183,Q13546,P05556,Q15041,Q15907,O75915 6 +Secondary alcohol metabolic process 0.4617787462848208 1.9431547227518715 0.051997466820437 1.0 0.4892925775833914 40 Q8WTV0,P04035,Q14534,P16435,O15118,Q16850,Q15800,O94905,P04062,Q15392,P37268,Q12770,O75845 13 +Fatty acid transmembrane transport 0.7322640748905013 1.937161644881741 0.0527255871255898 1.0 0.4921960781548981 7 P23786,P50416 2 +Regulation of amyloid precursor protein catabolic process 0.6267710972061121 1.9350668707882088 0.0529820902730884 1.0 0.4921960781548981 12 O95197,O75298,Q9NQC3 3 +Carbohydrate transmembrane transport 0.599016704133416 1.93491132429059 0.0530011783129431 1.0 0.4921960781548981 14 Q16625,O75298,Q9NY64 3 +Regulation of blood pressure 0.5628270648329883 1.934342348343264 0.0530710497086304 1.0 0.4921960781548981 17 Q9NZ08,P05023,Q9Y5X3,P42785,P09601,Q9HB40,Q9UIQ6,P42892 8 +Regulation of lipid metabolic process 0.4468933675742922 1.9251883647861 0.0542057971849272 1.0 0.493051839566146 47 Q96N66,Q8NF37,Q8WTV0,Q13510,P05023,P16435,O94905,Q99623,P30536,Q9NZJ7,Q9H6K4,O75844,Q12770,P50416 14 +Collagen metabolic process 0.6569056213010611 1.922524108844387 0.0545398429943613 1.0 0.493051839566146 10 Q32P28,P08670,Q9UBG0 3 +Regulation of hormone metabolic process 0.7830416173854984 1.9215950899614929 0.0546567269086943 1.0 0.493051839566146 5 P05023,O75844 2 +Alcohol biosynthetic process 0.4632195781160794 1.916085511388788 0.0553542121854615 1.0 0.4977279023656736 37 Q13510,P04035,P16435,Q16850,Q15800,O94905,P04062,Q15392,P00374,O15269,P37268,Q12770,O75845 13 +Carbohydrate transport 0.5600057333355737 1.915476354547585 0.0554317818298852 1.0 0.4977359995015425 17 Q9NY64,Q16625,O75298,P52789 4 +Cellular copper ion homeostasis 0.7812964245856435 1.9138193596028712 0.0556432409534455 1.0 0.4987222264647383 5 O43819,O75880,P35670 3 +Regulation of lysosomal lumen ph 0.7787782707827211 1.9025893174338144 0.0570941541534189 1.0 0.5051994982360092 5 P50897 1 +Regulation of response to extracellular stimulus 0.8494491753605389 1.8956685208290889 0.0580038903668249 1.0 0.5051994982360092 4 P80303 1 +Organic cation transport 0.7481136508888238 1.894915079482513 0.0581036530680787 1.0 0.5051994982360092 6 Q70HW3,Q9HC21,O43772 3 +Regulation of phosphatidylcholine metabolic process 0.8489394968711922 1.8935387226408855 0.0582862637367176 1.0 0.5051994982360092 4 Q8WTV0 1 +Phosphatidylserine metabolic process 0.7765942183139337 1.8928393594396975 0.0583792355659584 1.0 0.5053306630589366 5 Q8NCC3 1 +Neural retina development 0.7218800153765239 1.8873998319304437 0.0591065677205508 1.0 0.5086587261579129 7 P20020,Q8NBN7,P54802 3 +Lysosomal protein catabolic process 0.7461244884508468 1.8856958803139816 0.0593359483734081 1.0 0.5086587261579129 6 O14773,P13473 2 +Protein catabolic process in the vacuole 0.7461244884508468 1.8856958803139816 0.0593359483734081 1.0 0.5086587261579129 6 O14773,P13473 2 +Regulated exocytosis 0.4620420506894656 1.8829736757671631 0.0597039355102171 1.0 0.5086587261579129 35 P16615,Q12846,P61026,O95721,Q9P253,P09601,O43760,P49755,P11279,Q4J6C6,Q15907 11 +Cell cell adhesion via plasma membrane adhesion molecules 0.6297514856954343 1.8784232858273655 0.0603232824857322 1.0 0.5120015436038154 11 P98194,P05556,P35613,O15031,P78310 5 +Negative regulation of g protein coupled receptor signaling pathway 0.6827602026751639 1.86577561309869 0.0620727656185058 1.0 0.5192994773135823 8 P00813,Q9UHD9 2 +Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway 0.6821964581735802 1.8629139465131932 0.0624743743136626 1.0 0.5213157301340591 8 O43657 1 +Glycoside metabolic process 0.6637914595381487 1.8601334747142353 0.0628666441978766 1.0 0.5225896044271479 9 P06280,Q9NUJ1,Q9BTY2,P04062,P04066 5 +Divalent inorganic cation homeostasis 0.4239457629963693 1.8600319726478969 0.0628810025806241 1.0 0.5225896044271479 54 P20020,Q9UM00,Q9HD20,O95202,P16615,P98194,P23634,Q8TAD4,Q9Y4W6,Q15043,Q6P4Q7,Q16891,Q96TC7,P51572,P35670,Q9BPX6,Q8NE86,P07686,O76024,Q96HE7,Q96A33,Q8IYU8 22 +Membrane docking 0.4673070708519417 1.852645324494718 0.0639332114987045 1.0 0.5254637539886844 31 P16615,O15400,Q96GC9,P61026,O95721,O60499,O43752,Q9P253,Q13190 9 +Leukocyte mediated cytotoxicity 0.5853846340210613 1.85090012582578 0.0641839226591587 1.0 0.5254637539886844 14 P51809,P04439,P01889,O15400,P07437,P53634,P46108,P11279,Q9NVJ2,Q9NUQ9,P68371 11 +Positive regulation of response to endoplasmic reticulum stress 0.7142959776792772 1.8508886382811935 0.0641855756181495 1.0 0.5254637539886844 7 Q9UHD9,P57088,P46379,P51572,P18031 5 +Regulation of phospholipid metabolic process 0.6410783056923679 1.8364977084779224 0.0662840806982301 1.0 0.5338911313807815 10 Q99623,Q8WTV0 2 +Purine nucleoside metabolic process 0.6581221324922243 1.8302912978301904 0.0672063919477679 1.0 0.5399800699565708 9 O60725,P00813 2 +Cellular response to oxygen levels 0.4549460944736937 1.829011747656018 0.0673978483903539 1.0 0.5408489885663504 36 Q9Y487,O75306,Q8IXJ6,Q96A26,Q9Y4P3,Q04656,O95831,P55786,Q99623,P09601,P02545,Q15904 12 +Cellular iron ion homeostasis 0.5801200976035104 1.8182534648784263 0.0690254017327174 1.0 0.5474727683071685 14 Q9Y487,O75027,P09601,Q9H3K6,Q15904 5 +Lysosomal lumen acidification 0.8303316434459069 1.81551875173397 0.0694442269227364 1.0 0.5474727683071685 4 P50897 1 +Post embryonic development 0.6056912299441579 1.8126089050527017 0.0698921633597779 1.0 0.5474727683071685 12 O95470,Q9NX62 2 +Response to nitric oxide 0.7060189884522072 1.8108818743916244 0.0701591389106284 1.0 0.5474727683071685 7 P46108,O95831 2 +Cellular response to reactive nitrogen species 0.7060189884522072 1.8108818743916244 0.0701591389106284 1.0 0.5474727683071685 7 P46108,O95831 2 +Release of cytochrome c from mitochondria 0.5786567968313922 1.8091593066186316 0.0704262575782201 1.0 0.5488682643431038 14 O14737,Q96A26,Q9H300,Q9GZY8,O60313,Q9H3K2,Q3ZCQ8 7 +Phospholipid catabolic process 0.6049913725749071 1.808515809324186 0.0705262585449841 1.0 0.5489496243315538 12 Q8NCC3,Q8WTV0,Q8NHP8 3 +Sensory perception 0.4564549287984867 1.8061614359658404 0.0708931267259258 1.0 0.5490912070410991 32 Q14108,P50897,O60313,Q9Y6M9,P23634,Q6P4Q7,O76024,O43924,Q9H6K4 9 +Regulation of cardiac conduction 0.7564599848876403 1.802531570177845 0.0714618123001191 1.0 0.5490912070410991 5 P20020,P16615,Q6PI78 3 +Prostate gland development 0.7563686899724271 1.8021203678025812 0.0715264698387017 1.0 0.5490912070410991 5 Q05086,Q9NZJ7 2 +Reticulophagy 0.7563292759990907 1.8019428382016005 0.0715543994388123 1.0 0.5490912070410991 5 Q9Y6I9 1 +Sodium ion homeostasis 0.7030831301811149 1.7966517912671354 0.0723909167854408 1.0 0.5506719569535892 7 P05026,P04899,P05023,Q9Y5X3,P54709 5 +Lipoprotein localization 0.8254172015404243 1.7948297377043538 0.072680831265649 1.0 0.5506719569535892 4 Q96GC9,O15260,A6NIH7 3 +Negative regulation of secretion 0.5420590349148897 1.7945720171279012 0.0727219148648152 1.0 0.5506719569535892 17 Q16850,P00813,P09601 3 +Positive regulation of immunoglobulin production 0.6023491160490032 1.793046918042125 0.0729654222619644 1.0 0.5506719569535892 12 P35232,Q96FZ2,O96028,Q99623,Q12846 5 +Golgi vesicle budding 0.753968808562573 1.7913055776649478 0.0732442715647458 1.0 0.5506719569535892 5 Q15363,P49755 2 +Neuron recognition 0.7533714835577485 1.7886121709165408 0.0736772963851293 1.0 0.5506719569535892 5 Q9NQC3 1 +Retrograde transport endosome to golgi 0.4492903605242077 1.7880173434623197 0.0737732097385097 1.0 0.5506719569535892 37 O75503,O60749,Q8NBN3,Q9BVK6,Q9BXI6,Q9Y5X3,O60499,O43752,O95249,Q4J6C6,P49257,Q13190,O15260 13 +Phosphatidylinositol metabolic process 0.5001292849390392 1.784218600622954 0.0743881509784736 1.0 0.5506719569535892 22 Q96N66,Q5H8A4,O00459,Q9NTJ5,Q92643,Q96S52,Q10713,Q9NX62 8 +Organic hydroxy compound catabolic process 0.5746064241972906 1.7839421060866478 0.0744330730103139 1.0 0.5506719569535892 14 P21964,Q10713,Q9NX62 3 +Protein insertion into mitochondrial inner membrane 0.7520190581550231 1.782511538946843 0.0746658512242799 1.0 0.5506719569535892 5 Q53H12,Q9P0J0 2 +Phosphatidic acid metabolic process 0.6995539526291177 1.7795186505953688 0.0751547699536439 1.0 0.5506719569535892 7 Q9NPH0 1 +Glycosyl compound metabolic process 0.4691742247802472 1.7783180375352274 0.0753516355273224 1.0 0.5506719569535892 29 P06280,Q9NUJ1,Q9BTY2,O60725,P36639,P00813,P04062,P04066 8 +Golgi organization 0.3935119079175576 1.7776373717582932 0.075463431745433 1.0 0.5506719569535892 62 Q15363,Q96GC9,P61019,Q8TBA6,Q9P2W9,Q9Y3A6,Q13190,O15260,Q9BSR8,Q8NHH9,O43752,Q12907,Q7Z7H5,P49257,Q96JB2,P83436,Q7RTS9,P49755,Q9H4A6,Q9BVK6,Q14789,O75396,Q9Y3B3 23 +Activation of cysteine type endopeptidase activity involved in apoptotic process 0.5990042511252069 1.773429119771452 0.0761576273124735 1.0 0.5542772606643255 12 Q96A26,Q9BXK5,Q9NR28,Q9NZJ7 4 +Inositol phosphate metabolic process 0.6973940848785354 1.7690185205523536 0.0768907839007968 1.0 0.5583612629574644 7 Q10713 1 +Cellular response to sterol depletion 0.7195820410391583 1.7618653592275604 0.0780920486279137 1.0 0.5618730191476438 6 Q15363,O94905,Q12770 3 +Response to sterol depletion 0.7195820410391583 1.7618653592275604 0.0780920486279137 1.0 0.5618730191476438 6 Q15363,O94905,Q12770 3 +Neutral lipid biosynthetic process 0.746890073411447 1.759345355415222 0.0785188673071137 1.0 0.5618730191476438 5 Q8WTV0 1 +Modified amino acid transport 0.8165403216303077 1.7573742821925653 0.0788540339388261 1.0 0.5619323691886493 4 Q9H2D1,O43772 2 +Mammary gland epithelial cell proliferation 0.7461185703771096 1.7558566236107638 0.07911289305024 1.0 0.5631588834234194 5 Q9NQC3 1 +Regulation of phospholipase activity 0.6608565952346331 1.753963315995462 0.0794367931377679 1.0 0.563610558525016 8 P50897 1 +Negative regulation of leukocyte migration 0.7176820374558046 1.752944219117714 0.0796115823558289 1.0 0.5642340531157662 6 P00813 1 +Response to oxygen levels 0.3860565873132793 1.7520746617575669 0.0797609705643371 1.0 0.5644974559485699 65 Q9Y487,Q96A26,Q04656,Q99623,Q12770,P30519,P02545,P00846,Q9NY64,Q15904,O75306,P52789,Q8IXJ6,P00813,O95831,P55786,Q9Y4P3,Q92544,P09601,Q96HE7 20 +Regulation of immunoglobulin production 0.5554833017245737 1.7502017235229668 0.0800835115416871 1.0 0.5644974559485699 15 P35232,Q96FZ2,O96028,Q99623,Q12846 5 +Regulation of protein secretion 0.4438131019622616 1.7486396646008209 0.0803533254590294 1.0 0.5657850204772439 38 Q16850,P49755,Q9H4A6,Q8N5M9,Q96KC8,P50416 6 +Inositol phosphate catabolic process 0.8143157476446867 1.747970992150676 0.0804690505246714 1.0 0.5658505539459118 4 Q10713 1 +Homologous chromosome segregation 0.6227713891834376 1.736017385009505 0.0825607606420824 1.0 0.5762330023870391 10 Q15645,P46379,Q92791,Q9BTX1 4 +Positive regulation of erad pathway 0.8106546854942168 1.7324812690001408 0.0831879092711671 1.0 0.5762330023870391 4 P46379,P51572,Q9UHD9 3 +Regulation of glycoprotein metabolic process 0.6220809995609705 1.7322079744554253 0.0832365397193868 1.0 0.5762330023870391 10 Q99805,Q92542 2 +Intracellular lipid transport 0.59114352716223 1.7271705931188843 0.0841370304707809 1.0 0.5762330023870391 12 P23786,O15118,P50416 3 +Homologous chromosome pairing at meiosis 0.6382765573800728 1.7251023066895483 0.0845090369271184 1.0 0.5762330023870391 9 Q15645,P46379,Q92791,Q9BTX1 4 +Regulation of mitochondrial gene expression 0.5896071810327268 1.7181043707412271 0.0857775797621627 1.0 0.5806043811487871 12 Q567V2 1 +Apoptotic mitochondrial changes 0.4570776258457222 1.7176719392616286 0.0858564704101718 1.0 0.5806043811487871 30 O14737,P52789,Q96A26,P45880,Q9H300,Q9GZY8,O60313,Q9H3K2,P02545,Q3ZCQ8 10 +Regulation of appetite 0.9788325849903796 1.7104254825851952 0.0871872221639191 1.0 0.5843191386227828 2 P80303 1 +Negative regulation of response to food 0.9788325849903796 1.7104254825851952 0.0871872221639191 1.0 0.5843191386227828 2 P80303 1 +Regulation of response to food 0.9788325849903796 1.7104254825851952 0.0871872221639191 1.0 0.5843191386227828 2 P80303 1 +Regulation of anion transmembrane transport 0.7082677443144392 1.708632246130387 0.0875190916500139 1.0 0.5857463329813303 6 P08183,O75915,Q15041,P05556 4 +Lipoprotein metabolic process 0.5079660039542819 1.7074387990937372 0.0877405240068696 1.0 0.5860200430582279 19 Q9NUJ1,Q5HYI8,Q9H6R6,Q5H8A4,P50897,P04062 6 +Membrane fusion 0.4285615866677403 1.7043742814956475 0.088311185543334 1.0 0.5877108119020622 45 Q9BZG1,Q9BSR8,O15400,Q9Y3E7,Q9P2W9,O95721,O43752,O60499,O95249,Q12846,Q12981,O75396,Q13190,Q9UQN3,P31751 15 +T cell differentiation in thymus 0.6340706460513176 1.70266715531558 0.0886303747650814 1.0 0.5877108119020622 9 P04062,O96005,P00813 3 +Body fluid secretion 0.5382795247822862 1.7007584001153802 0.0889883637892425 1.0 0.5880605758562448 16 P52789,P00813,Q13505,P35670,P00403 5 +Positive regulation of toll like receptor signaling pathway 0.7334888482640824 1.698596875703347 0.089395165543598 1.0 0.5885937268854347 5 P41440,Q9NQC3 2 +Xenobiotic transport 0.8010581316256673 1.6917959083216378 0.0906848940275721 1.0 0.5908107371135758 4 P08183,P35670 2 +Signaling receptor ligand precursor processing 0.799101412066732 1.6834858679601523 0.0922810728665504 1.0 0.5923390560962275 4 Q8TAD4,P42892,O75787 3 +Negative regulation of lipid biosynthetic process 0.6292632730247634 1.676964139603598 0.0935494944411703 1.0 0.597178678429558 9 O94905,P05023,Q8NF37,Q12770 4 +Endoplasmic reticulum to cytosol transport 0.5819363215110434 1.6727158319328916 0.0943832510328948 1.0 0.5984079495711414 12 Q96CS3,Q9UBV2,P51572,Q9BUN8,Q8TCT9 5 +Connective tissue development 0.4652400182416238 1.6667196681402088 0.0955701601414857 1.0 0.6017209217889488 27 Q92896,P16435,Q15043,Q04656,Q9NX62,O75844,P43490 7 +Regulation of t cell differentiation in thymus 0.9682488774855684 1.6666074657836278 0.0955924833956289 1.0 0.6017209217889488 2 P00813 1 +Skeletal system morphogenesis 0.512254083260522 1.661130799934236 0.096687179840988 1.0 0.6029713463282368 18 O95470,O75844,P16435,Q9NX62 4 +Regulation of adaptive immune response 0.4902892668920356 1.6595907046208818 0.0969968195809123 1.0 0.6031389902886024 20 P04439,P01889,O15400,Q96FZ2,O96028,P00813,P02786 7 +Chondrocyte differentiation 0.5912258356585032 1.6585526985916388 0.0972059600532671 1.0 0.6031389902886024 11 P16435,Q15043,Q9NX62 3 +Regulation of er to golgi vesicle mediated transport 0.7246205076485335 1.6582278202967995 0.0972714915021821 1.0 0.6031389902886024 5 Q9P2W9,Q9NR31,Q6NUQ1 3 +Positive regulation of lipid biosynthetic process 0.6084058852387043 1.6564580202522248 0.0976290996928725 1.0 0.6041297855532727 10 Q8WTV0,Q12770 2 +Long chain fatty acid transport 0.5786189047591928 1.6530245868115956 0.0983258597864416 1.0 0.6054160949185533 12 P23786,P50416 2 +Natural killer cell mediated immunity 0.6077129042255831 1.6526047292830697 0.0984113349585504 1.0 0.6054160949185533 10 P51809,P04439,P01889,P07437,P46108,P11279,Q9NVJ2,P68371 8 +Plasma membrane organization 0.4444226516767359 1.651241027886697 0.0986893685891474 1.0 0.6054160949185533 31 P16615,P41440,Q4KMQ2,Q96GC9,Q9HD42,Q9Y3E7,Q9Y371,Q9UQB8,Q96CP7,Q12846,O75955,Q9UQN3,P31751 13 +Inorganic ion import across plasma membrane 0.6243475118286863 1.6506167895626225 0.0988168483698885 1.0 0.6054160949185533 9 P05026,P05023,Q15043,P23634,P54709 5 +Chloride transmembrane transport 0.7223841363028679 1.6480272999064474 0.0993470692187368 1.0 0.6054160949185533 5 Q9UHG3,P51790,Q4KMQ2 3 +Regulation of heart contraction 0.4580930562745866 1.6442292866294832 0.1001288496191061 1.0 0.6054160949185533 28 P16615,P20020,P05023,Q6PI78,P10253,P00813,P78310,O75844 8 +Copper ion transport 0.789794608472384 1.64389644256982 0.1001975951270104 1.0 0.6054160949185533 4 Q04656,P35670,Q8N4V1 3 +Phosphatidylcholine catabolic process 0.9618345093008338 1.640027580048845 0.1009994325737213 1.0 0.6058834586017839 2 Q8WTV0 1 +Cellular lipid catabolic process 0.3776041179188997 1.636107345199927 0.1018171232024649 1.0 0.6058834586017839 66 Q13011,P06280,P17900,Q8WTV0,Q13510,O95470,P50897,Q9NZC3,P04066,Q9BWD1,Q8NCC3,P06865,P23786,Q8NHP8,P50416 15 +Chaperone mediated autophagy 0.6698041288725454 1.6339396876200594 0.1022715152801434 1.0 0.6062147697993983 7 P10619 1 +Mitochondrial protein processing 0.6695954036006742 1.6329112321612114 0.1024876674728876 1.0 0.6062147697993983 7 Q9Y4W6,Q96E52,Q96TA2,Q10713 4 +Estrogen metabolic process 0.7183512312936178 1.6296120975650503 0.103183505950144 1.0 0.6062147697993983 5 O95470 1 +Neuromuscular process controlling balance 0.5859045535771545 1.6278024150269743 0.103566788300613 1.0 0.6073672896545438 11 O14773,P07196,P17900 3 +Cartilage development involved in endochondral bone morphogenesis 0.7852585400266834 1.6245636476141627 0.1042555682537726 1.0 0.6097541883815246 4 O75844 1 +Positive regulation of leukocyte proliferation 0.5607461954848497 1.618089248658382 0.1056433651794008 1.0 0.6123542203077414 13 P04439,P27361,P30825,P00813,Q5ZPR3,P02786 6 +Insulin secretion involved in cellular response to glucose stimulus 0.601009355636625 1.6152583268914005 0.1062547641760973 1.0 0.61435093376038 10 Q15907 1 +Outer mitochondrial membrane organization 0.714625600879009 1.6125771156036262 0.106836413579753 1.0 0.6159698019180788 5 Q9NS69,Q9Y512 2 +Regulation of mitochondrion organization 0.4074750110104375 1.6087866364284478 0.1076630039651098 1.0 0.616840147495304 51 Q9UG56,Q96A26,Q9H300,Q8N2A8,P21796,Q709C8,Q9H6R6,Q13501,P02545,O43464,P12235,Q9GZY8,O60313,P30536,Q9H4A6,P05141,Q8NE86,Q96E52,Q9Y6C9,O14737,Q9H3K2,P02786 22 +Hormone biosynthetic process 0.6327343686387809 1.6085869432276525 0.1077066911256097 1.0 0.616840147495304 8 P05023,P16435,Q53GQ0 3 +Cardiac conduction 0.504795433732291 1.6083131420546062 0.1077666138065163 1.0 0.616840147495304 18 P16615,P20020,P05023,Q6PI78,P78310,O75844 6 +Cell adhesion molecule production 0.7813687247590358 1.6079665323084371 0.1078425088427557 1.0 0.616840147495304 4 P41440,Q9H4A6 2 +Er overload response 0.7122359720390725 1.6016394830018807 0.1092353545302482 1.0 0.6192002797736779 5 O76024,Q96A33 2 +Cellular response to virus 0.4824520387230572 1.6006927905024506 0.1094449787582239 1.0 0.6192002797736779 20 Q99623,O43657 2 +Response to cadmium ion 0.557789721068083 1.599916203207671 0.1096171742656475 1.0 0.6192002797736779 13 P09601,P36639,O15118 3 +Organic hydroxy compound biosynthetic process 0.4044317552671746 1.5996054274633904 0.1096861436632412 1.0 0.6192002797736779 52 Q13510,P04035,Q14534,P16435,Q04656,Q16850,O94905,P04062,Q15392,Q15800,P00374,O15269,P37268,Q12770,O75845 15 +Glucose import 0.580823838719461 1.5983597135719525 0.109962945032076 1.0 0.6192002797736779 11 Q16625,O75298 2 +Leukocyte tethering or rolling 0.7788555746547643 1.5972344689680675 0.1102134519843003 1.0 0.6192002797736779 4 Q9H4A6,Q11206 2 +Regulation of morphogenesis of a branching structure 0.9376795284540992 1.5924952819142273 0.111273462384732 1.0 0.6200749509027298 3 Q9NQC3 1 +Calcium ion import into sarcoplasmic reticulum 0.9486850545221328 1.585495693450668 0.1128537546165726 1.0 0.6231974899664647 2 O75844 1 +Regulation of erad pathway 0.6594717814752031 1.5829155989542762 0.1134407028368267 1.0 0.624068800535291 7 P46379,P51572,Q9UHD9 3 +Negative regulation of immune effector process 0.5781248802415697 1.5826869658411824 0.1134928305793663 1.0 0.624068800535291 11 P04439,P09601,Q08722,P46108 4 +Regulation of toll like receptor signaling pathway 0.6809686451441106 1.5791569776379455 0.1143000552998074 1.0 0.626419192009908 6 P41440,O75955,Q9NQC3 3 +Glycerophospholipid catabolic process 0.626732790297964 1.5773108317035258 0.1147240212714615 1.0 0.6268963403815537 8 Q8NCC3,Q8WTV0 2 +Low density lipoprotein particle clearance 0.5942122270330816 1.5772602485847624 0.1147356550371994 1.0 0.6268963403815537 10 P09601,Q8WTV0 2 +Negative regulation of cellular response to growth factor stimulus 0.5771218526276027 1.5768567746611168 0.1148284844690534 1.0 0.6268963403815537 11 O14936,Q8NC56,O14964,P23634,Q9Y2U8,P18031,Q8N0X7 7 +Sterol homeostasis 0.57665183789327 1.5741237231071252 0.1154588490776338 1.0 0.6268963403815537 11 Q8WTV0,O15118 2 +Potassium ion homeostasis 0.7060861511632464 1.5734511391982522 0.115614393616038 1.0 0.6268963403815537 5 P05026,P05023,P54709 3 +Perk mediated unfolded protein response 0.77324680074521 1.5732584963739131 0.1156589753303323 1.0 0.6268963403815537 4 Q15363,P57088 2 +Plasma lipoprotein particle clearance 0.5764459023734672 1.5729260348541874 0.1157359459002036 1.0 0.6268963403815537 11 P09601,Q8WTV0 2 +Regulation of monooxygenase activity 0.5933362134388585 1.5723536867835362 0.1158685486643096 1.0 0.6268963403815537 10 P06280,Q8WTV0,P16435,Q04656,P00374,Q8TCT9 6 +Behavior 0.3810823047894454 1.5723158143278162 0.1158773272424313 1.0 0.6268963403815537 74 O15118,Q04656,P04062,P50416,Q9BPZ3,P04035,P50897,Q92542,P17900,Q15154,P05556,P30536,O75844,Q9NRG9,Q13641,P07686,Q05086,P10253,O76024,P51790,P54802,O00264 22 +Vesicle docking 0.5190403324871905 1.571765826860272 0.1160048695312705 1.0 0.6270637910050028 16 O15400,P61026,Q9P253,O60499,O43752,Q13190 6 +Mating 0.7725730465382151 1.5703761628543025 0.1163276246872149 1.0 0.6270649371981969 4 P00813 1 +Nucleobase containing small molecule catabolic process 0.7048318106573821 1.5676948347351976 0.1169523677118618 1.0 0.6274832819714106 5 P00813 1 +Positive regulation of pattern recognition receptor signaling pathway 0.6087117905425865 1.5663891426697971 0.117257543190536 1.0 0.6284586867922257 9 P41440,Q9NUD5,Q9NQC3 3 +Regulation of glucose import 0.6086133883763531 1.5658570737462512 0.117382081192495 1.0 0.6284586867922257 9 Q16625,O75298 2 +Potassium ion import across plasma membrane 0.6781428590729842 1.565675596696415 0.1174245821132116 1.0 0.6284586867922257 6 P05026,P05023,P54709 3 +Cobalt ion transport 0.9429121231558774 1.5615413040427375 0.1183960862364041 1.0 0.6312378026255718 2 Q8N4V1 1 +Protein targeting to membrane 0.4228197673387969 1.5613001516289902 0.1184529478487346 1.0 0.6312378026255718 39 O43681,Q9H6R6,O60725,P43307,Q9GZY8,Q9UNL2,Q99442,O00560,O43765,P46379,P40855,Q15041,Q5BJH7,Q15629,Q9UGP8 15 +Mammary gland epithelium development 0.6548448925223704 1.5599931261682978 0.1187615055850166 1.0 0.6312378026255718 7 Q9NQC3 1 +Cd40 signaling pathway 0.7700862019661732 1.5597333788767629 0.1188229007552168 1.0 0.6312378026255718 4 P35232,Q99623 2 +Protein localization to lysosome 0.5386766638828586 1.557447362301419 0.1193643087164892 1.0 0.6312378026255718 14 Q14108,P13473,Q9NQC3 3 +Protein depalmitoylation 0.7022248723425208 1.5557239914919292 0.1197737390502131 1.0 0.6312378026255718 5 P50897 1 +Lipoprotein catabolic process 0.7022248723425208 1.5557239914919292 0.1197737390502131 1.0 0.6312378026255718 5 P50897 1 +Receptor localization to synapse 0.5732499062911204 1.5543223128543422 0.1201075537626095 1.0 0.6312378026255718 11 P57105,Q14118,O15400 3 +Double strand break repair via break induced replication 0.6218606379709196 1.5518586774394048 0.1206960422185285 1.0 0.6324121921571328 8 Q14566,Q9Y248 2 +Transepithelial transport 0.7681014296672843 1.551234818609298 0.1208454208335683 1.0 0.6325081929023003 4 P08183 1 +Positive regulation of adaptive immune response 0.5155704575117483 1.5483372761631025 0.1215411141777256 1.0 0.6336403862388905 16 P04439,P01889,O15400,Q96FZ2,P00813,O96028,P02786 7 +Adp transport 0.7670089858793273 1.5465554433434625 0.1219704809502069 1.0 0.6336601534142041 4 P12236,P12235,O43808 3 +Regulation of neurotransmitter uptake 0.6984288876820085 1.5382757823853834 0.1239811984942587 1.0 0.6423670715281146 5 P41440,O75955,P05556 3 +Detection of biotic stimulus 0.7644415917843222 1.535553709976409 0.124647874636155 1.0 0.6442786641225464 4 P04439,P30536,Q8WTV0 3 +Response to ph 0.6977142288478433 1.534988596081381 0.1247866292775694 1.0 0.6442831463233318 5 Q15907 1 +Regulation of cellular extravasation 0.9352148813341884 1.529594314971134 0.1261171775177803 1.0 0.64826026638593 2 Q11206 1 +Neuron apoptotic process 0.4054014450633258 1.5241405741447296 0.1274735989934987 1.0 0.6517837730252763 48 Q01105,Q99720,Q9NR28,Q96A26,Q07820,P50897,Q92542,P04062,P09601,O76024,P07196 11 +Lactation 0.5333632398531643 1.523544100111527 0.1276226362981507 1.0 0.6517837730252763 14 P00403,Q13505,P35670,P52789 4 +Ubiquitin dependent erad pathway 0.4237310029492788 1.5232097099688933 0.1277062475798138 1.0 0.6517837730252763 34 Q96CS3,P27824,Q9UHD9,O75477,O94905,Q9UBV2,O43765,P51572,P46379,Q9BUN8,O76024,Q96A33 12 +Cellular sodium ion homeostasis 0.6950240770465509 1.5226085032329162 0.1278566811294119 1.0 0.6520389425704183 5 P05026,P05023,P54709,P55011 4 +Ion transport 0.4946490717399282 1.5215213768939524 0.1281290510048902 1.0 0.6524029797049 209 Q8N668,P41440,Q8N4V1,Q9H9B4,Q9H2D1,Q9UDW1,Q9UHG3,Q9Y277,O43808,Q15907,P21796,Q14728,O75964,Q8TDW0,P13073,P24539,O60831,P02792,P45880,P00846,Q9H0U3,Q9BVC6,P20674,P12235,Q9Y4W6,P30825,P05556,Q9UBX3,O75844,P00403,P12236,Q13423,Q96HE7,Q4KMQ2,P02786,O75915,Q8IYU8,P0CG08,O75027,Q02790,Q99623,Q9HD20,Q7KZN9,P05026,O75947,P16615,P08195,Q70HW3,Q96NB2,Q8TAD4,Q9NZD2,Q9NY64,P08183,P04899,Q8TB61,P05023,Q08722,Q9NZJ7,P05141,P36543,Q9H0H5,Q15758,O00483,Q14847,P54709,O76024,Q9UJZ1,Q8WWC4,Q13546,Q9NW15,Q9H936,Q96GC9,Q02978,P55011,Q15041,Q8NE01,O95202,Q8WWI5,P98194,O43772,Q9BQT8,Q9UJS0,Q15043,P30536,P35670,P56385,Q9BPX6,Q6P4A7,Q9HC21,P51790,Q6NUK1,P20020,Q9UM00,Q04656,O75746,P23634,P06576,Q6P4Q7,Q8NE86,O43681,O96008,Q9Y6M7 102 +Pattern recognition receptor signaling pathway 0.4517891790469954 1.5208748196960404 0.1282912539843554 1.0 0.6527169442526927 26 Q99623,Q9NQC3,O43657 3 +Regulation of response to osmotic stress 0.6939475138384747 1.5176513912236005 0.1291023040918193 1.0 0.6527448181071741 5 P08183,O95202 2 +Cytoplasmic pattern recognition receptor signaling pathway 0.5196510039839337 1.5160108385900994 0.1295166117830686 1.0 0.6527448181071741 15 Q99623,O43657 2 +Positive regulation of necrotic cell death 0.6928264376652895 1.512487660040621 0.1304098495302503 1.0 0.6527448181071741 5 P00403 1 +Positive regulation of lipid metabolic process 0.5102674187541247 1.5124380028882225 0.1304224732703449 1.0 0.6527448181071741 16 P16435,Q8WTV0,Q12770,P50416 4 +Primary alcohol metabolic process 0.4911733748477827 1.511187356847193 0.1307407227082535 1.0 0.6527448181071741 18 Q9BY49,Q8NBN7,P51648,P30837,Q9NZC3 5 +Cation transport 0.4561732134643828 1.5094617826411856 0.1311808147102193 1.0 0.6527448181071741 159 Q8N668,Q9NW15,O75027,Q8N4V1,Q9H9B4,P20020,Q96GC9,Q9UM00,Q04656,Q9UDW1,Q02790,Q99623,Q9HD20,O43808,Q15907,P21796,Q7KZN9,O95202,O75964,P05026,P13073,O75947,P16615,P24539,P98194,O43772,P08195,P02792,Q70HW3,Q96NB2,P23634,Q8TAD4,P00846,Q9H0U3,P20674,P12235,P04899,Q9Y4W6,P05023,P30825,Q15043,P06576,P05556,Q6P4Q7,P30536,P35670,P05141,O75844,P56385,P00403,Q9BPX6,Q8NE86,P36543,Q13423,Q15758,O00483,Q9UJZ1,P54709,Q9HC21,O76024,Q96HE7,P51790,Q4KMQ2,P02786,Q9Y6M7,Q8WWC4,Q8IYU8 67 +Regulation of defense response to virus 0.5184609467492327 1.5081466841572548 0.1315169892425332 1.0 0.6527448181071741 15 O43657 1 +Phosphatidylethanolamine metabolic process 0.9159448187359628 1.50763819132169 0.1316471525645592 1.0 0.6527448181071741 3 Q8NCC3,P35790 2 +Cellular response to exogenous dsrna 0.6441444978006969 1.506813531611594 0.1318584601057089 1.0 0.6527448181071741 7 P41440,Q9NUD5 2 +Autophagosome membrane docking 0.915303176130894 1.5051302259266577 0.132290599390989 1.0 0.6527448181071741 3 O95721,P16615 2 +Regulation of glucose transmembrane transport 0.5646567430460465 1.5041527077346175 0.1325420515196924 1.0 0.6527448181071741 11 Q16625,O75298 2 +Myeloid leukocyte migration 0.4570002852181876 1.502812209820852 0.1328874764672651 1.0 0.6527448181071741 24 Q8NE86,Q00013,Q08722,P35613,Q4KMQ2,P78310,Q8N5M9,Q8NHP6 8 +Regulation of t cell mediated cytotoxicity 0.7567394094993513 1.502511691690778 0.1329650107555613 1.0 0.6527448181071741 4 P01889,P04439,O15400 3 +Positive regulation of t cell mediated cytotoxicity 0.7567394094993513 1.502511691690778 0.1329650107555613 1.0 0.6527448181071741 4 P01889,P04439,O15400 3 +Regulation of membrane lipid distribution 0.6903771748475944 1.5012004356859554 0.1333037273179316 1.0 0.6527448181071741 5 P08183,Q96GC9,Q4KMQ2 3 +Receptor metabolic process 0.4227231145726955 1.5009934007849164 0.1333572684431208 1.0 0.6527448181071741 32 P41440,Q9UHD9,Q9Y371,P02786,O00560,P05556,Q8IZ07,Q15907,P18031,O75955,P42892 11 +Odontogenesis of dentin containing tooth 0.6646125394381668 1.5009335208152816 0.1333727570551277 1.0 0.6527448181071741 6 P35613 1 +Response to nerve growth factor 0.6118367843059176 1.499325517174491 0.1337892057236209 1.0 0.6527448181071741 8 P33240,Q05086,P46108,Q9H4M9 4 +Regulation of lymphocyte mediated immunity 0.468720061558389 1.4967283434795304 0.1344639580821955 1.0 0.6527448181071741 20 P04439,P01889,O15400,Q96FZ2,O96028,P46108,P11279,P02786 8 +Protein targeting to lysosome 0.5633832702949353 1.4966996553948202 0.1344714259843156 1.0 0.6527448181071741 11 Q14108,P13473 2 +Polyol metabolic process 0.4524406940045739 1.4949938632539437 0.1349160437298802 1.0 0.6527448181071741 25 Q13510,P04062,Q10713,Q9NX62,O15269 5 +Walking behavior 0.7547958314097958 1.494165501963818 0.135132366991121 1.0 0.6530023104413029 4 O75844 1 +Glycerolipid catabolic process 0.5792292514907819 1.4930552205112366 0.1354227328116233 1.0 0.6531681882712174 10 Q9NZC3,Q8NCC3,Q8WTV0 3 +L aspartate transmembrane transport 0.7538510911424794 1.4901074013044664 0.1361959984312313 1.0 0.6555927940719612 4 O75746,Q9UJS0,Q15758 3 +Aspartate transmembrane transport 0.7538510911424783 1.4901074013044622 0.1361959984312324 1.0 0.6555927940719612 4 O75746,Q9UJS0,Q8TDW0 3 +Regulation of leukocyte mediated cytotoxicity 0.640767712164839 1.4899842182625391 0.1362283855827288 1.0 0.6555927940719612 7 P04439,P01889,O15400,P46108,P11279 5 +Nucleoside catabolic process 0.7532054864283853 1.4873337979238994 0.1369266722432462 1.0 0.6557915700765344 4 P00813 1 +Adult behavior 0.4774151025268698 1.4839753644803877 0.1378154563482794 1.0 0.6557915700765344 19 O75844,P50897,O15118 3 +Retina morphogenesis in camera type eye 0.7519255455712173 1.4818339844766228 0.1383844740258326 1.0 0.6557915700765344 4 Q8NBN7,Q16706,P54802 3 +Determination of adult lifespan 0.6604034574789424 1.4807314916582637 0.1386781386923012 1.0 0.6557915700765344 6 O75844 1 +G protein coupled receptor signaling pathway 0.4132638412409524 1.4804939322022128 0.1387414788532543 1.0 0.6557915700765344 40 Q99720,Q9UHD9,Q8NCG7,Q15043,Q9Y3E5,P00813,Q9NZJ7,P42892 8 +Protein localization to vacuole 0.4663078154346625 1.4783681592909983 0.1393092631002761 1.0 0.6557915700765344 20 Q14108,Q92783,P13473,Q9NQC3,Q9Y371,Q9H9H4,P20645 7 +Positive regulation of anion transmembrane transport 0.7509276482159527 1.477545165374612 0.1395295607403817 1.0 0.6557915700765344 4 P08183,Q15041 2 +Regulation of body fluid levels 0.3970089525750938 1.475876443109179 0.1399770644765714 1.0 0.6557915700765344 50 Q9BWH2,P52789,P00813,P04062,Q13505,O76024,P35670,P00403,P38435,Q11206 10 +Cellular response to topologically incorrect protein 0.4199281726809937 1.4753191570936817 0.1401267584195749 1.0 0.6557915700765344 32 Q15363,P57088,Q96HY6,P48723,P46379,Q9BUN8,O76024,Q96HE7,P18031,Q9Y4P3 10 +Chemosensory behavior 0.9220654265554842 1.4750121079290637 0.1402092882418715 1.0 0.6557915700765344 2 Q13641 1 +Olfactory behavior 0.9220654265554842 1.4750121079290637 0.1402092882418715 1.0 0.6557915700765344 2 Q13641 1 +Negative regulation of nitric oxide metabolic process 0.6844042807668935 1.473642414873236 0.1405778949518847 1.0 0.6561372064656024 5 P06280,P30536 2 +Cellular extravasation 0.6067316214880752 1.4724863243009796 0.1408895973217883 1.0 0.6561372064656024 8 Q08722,Q11206,Q9H4A6,P05556 4 +Regulation of ire1 mediated unfolded protein response 0.6828646804338349 1.466531709124166 0.1425034891781051 1.0 0.6575214298111293 5 P57088,Q96HY6 2 +Membrane protein intracellular domain proteolysis 0.9198203976908268 1.4656941095739373 0.1427316396263482 1.0 0.6576393218270071 2 Q92542 1 +Retrograde transport vesicle recycling within golgi 0.6822545707113732 1.4637130958356412 0.1432723557924764 1.0 0.6577213546155473 5 Q96JB2 1 +Lipid biosynthetic process 0.4353213865131354 1.463542798424618 0.1433189115951236 1.0 0.6577213546155473 139 Q9H7Z7,Q9UG56,Q9NPH0,Q9NTJ5,O95749,P04062,Q06136,Q15392,Q92643,Q86YN1,O15269,Q12770,Q96N66,Q8NF37,Q13510,Q14534,P04035,O75477,Q53H12,P16435,Q9BVG9,Q10713,Q9NX62,Q11206,P35790,O95674,Q99805,Q9P035,Q8NBX0,P05023,Q9BY49,O94905,P30536,P37268,O75845,Q8WTV0,O95470,Q5H8A4,Q8NCG7,Q16850,Q15800,O00116,Q8NCC3,Q53GQ0 44 +Mitochondrion endoplasmic reticulum membrane tethering 0.9046319887574942 1.4634023381145254 0.1433573192823474 1.0 0.6577213546155473 3 P16615 1 +Cellular potassium ion homeostasis 0.7474326059050092 1.4625177534411928 0.143599382972976 1.0 0.6579068293577081 4 P05026,P05023,P54709 3 +Neuron cellular homeostasis 0.6565727734533569 1.4623214498474897 0.143653143285626 1.0 0.6579068293577081 6 P20020,P23634,P51790 3 +Excretion 0.6554246500097961 1.4567992565670498 0.1451718011882201 1.0 0.660349200576033 6 P09601 1 +Regulation of amyloid beta clearance 0.6806692398823062 1.4563870231875709 0.1452856608339141 1.0 0.660349200576033 5 Q16850 1 +Endomembrane system organization 0.4688304136724479 1.4544683545499013 0.1458165008812477 1.0 0.660349200576033 181 P41440,Q8N4V1,Q15006,P61026,O94901,Q9P2W9,Q9UQB8,Q13190,Q5JRA6,Q14108,Q9Y3E7,P02545,Q12846,Q8N1F7,O95197,Q9NQC3,Q5JTV8,O43765,Q9H9H4,O75844,Q92783,Q9BVK6,P78537,Q14789,Q4KMQ2,O75396,O75955,Q96A33,Q15363,P61019,P50402,P31751,P16615,Q13501,Q8NHH9,Q5J8M3,Q12907,Q96CP7,Q7Z7H5,Q8N5M9,P49257,Q96JB2,P83436,Q7RTS9,Q9HD42,O95721,O43760,P49755,Q9H4A6,Q12981,Q96GC9,Q86XL3,Q8TBA6,Q9NPA0,Q15041,O15260,Q9Y2U8,Q00765,Q15629,O14657,Q9Y371,Q9P253,P51790,Q9Y3B3,Q9Y3A6,Q9BSR8,O43752,Q8NC56,Q9H6H4,Q9UQN3,Q9ULX6,Q8IXJ6,Q9UH99,Q9BTV4,P20700,O43681,P57088,P46379 78 +Positive regulation of mitochondrial calcium ion concentration 0.6548722553007069 1.4541416643549814 0.1459070343341491 1.0 0.660349200576033 6 P51572,Q8IYU8,Q8NE86,Q9BPX6 4 +Acidic amino acid transport 0.5340689555527535 1.4530452959195823 0.1462111780304875 1.0 0.6605160608181987 13 Q9H936,O60831,O75746,P05556,Q9UJS0,Q15041,O75915,Q8TDW0 8 +Regulation of endoplasmic reticulum tubular network organization 0.6798227608131108 1.452474084140502 0.1463698300641378 1.0 0.6605160608181987 5 Q15041 1 +Dna protection 0.9159717767799932 1.4497220239280748 0.1471360515648814 1.0 0.6621515850593117 2 P36639 1 +Response to muscle activity 0.6791574289211542 1.449397927264393 0.1472264872021007 1.0 0.6621515850593117 5 Q9UDX5 1 +Pigment granule localization 0.6537533075750375 1.4487569645129137 0.1474054659888981 1.0 0.6621515850593117 6 Q15907 1 +Phosphatidylethanolamine biosynthetic process 0.9156510583707498 1.4483911293424525 0.1475076942479387 1.0 0.6621515850593117 2 P35790 1 +Cellular response to increased oxygen levels 0.6782476340463396 1.4451906650514887 0.1484043377352462 1.0 0.6621515850593117 5 Q9Y487 1 +Positive regulation of monooxygenase activity 0.6766445585836983 1.4377750791224402 0.150497882467997 1.0 0.66298127007568 5 P16435,Q8WTV0,P00374 3 +Multicellular organism aging 0.5850054003692086 1.4375316631180697 0.1505669826230045 1.0 0.66298127007568 9 P04062,O75844 2 +Protein insertion into er membrane 0.5199419751176024 1.4374742064569033 0.1505832967635278 1.0 0.66298127007568 14 Q8N4V1,O43681,Q15006,O43765,P46379,Q9NPA0,Q15629,Q96A33 8 +Vitamin d metabolic process 0.9127645926876202 1.4364140112585373 0.1508845685585438 1.0 0.66298127007568 2 P38435 1 +Lipid glycosylation 0.9127645926876196 1.4364140112585355 0.1508845685585442 1.0 0.66298127007568 2 Q11206 1 +Multicellular organismal signaling 0.4484076300670936 1.433527147098731 0.1517072465479911 1.0 0.6645120259586599 24 P16615,P20020,P05023,Q6PI78,P04062,P78310,O75844 7 +Cellular response to cadmium ion 0.739901222895319 1.430104626508211 0.1526869925597402 1.0 0.6674681668159591 4 P09601,Q04656 2 +Protein localization to membrane raft 0.7394094993581464 1.4279870004119264 0.153295600234534 1.0 0.6674681668159591 4 P05026,P41440,O75955 3 +Regulation of cell killing 0.5981794303201674 1.4274045164851283 0.1534633297515664 1.0 0.6677506278466281 8 P04439,P01889,O15400,P46108,P11279 5 +Manganese ion transport 0.89412897016362 1.4223074618577511 0.154937013645938 1.0 0.6723603560089771 3 P98194,Q9HD20 2 +Manganese ion transmembrane transport 0.89412897016362 1.4223074618577511 0.154937013645938 1.0 0.6723603560089771 3 P98194,Q9HD20 2 +Peptidyl proline hydroxylation 0.6476823414802841 1.4195098201721452 0.1557504359246668 1.0 0.6736387941525231 6 Q32P28,P13674,Q96HE7,O75718 4 +Phosphatidylcholine acyl chain remodeling 0.9076330981398386 1.415126332891141 0.1570314586722898 1.0 0.6752600673117632 2 Q8NF37 1 +Regulation of plasma lipoprotein particle levels 0.5279149450294498 1.4146502117764554 0.1571710789603493 1.0 0.6752600673117632 13 P09601,Q8WTV0 2 +Endosome organization 0.4264707455094291 1.4098803466220404 0.1585750167786837 1.0 0.6785574808705561 29 Q14108,Q15075,Q92783,Q13501,Q9Y3E7,O14964,Q9HD42,Q9P253,O43752,O60493,Q9BTU6,Q6IAA8,Q9H9H4,P51790,Q9UQN3,P61020 16 +Cellular response to estradiol stimulus 0.734615386086043 1.4073328351890528 0.159328717149259 1.0 0.6787152439192844 4 O95831 1 +Establishment of pigment granule localization 0.7339625961771672 1.404519368605599 0.1601642482145759 1.0 0.6809514876738593 4 Q15907 1 +Positive regulation of steroid biosynthetic process 0.9044259140474668 1.4018255099373522 0.1609673587737061 1.0 0.6809514876738593 2 Q12770 1 +Positive regulation of alcohol biosynthetic process 0.9044259140474668 1.4018255099373522 0.1609673587737061 1.0 0.6809514876738593 2 Q12770 1 +Positive regulation of steroid metabolic process 0.9044259140474668 1.4018255099373522 0.1609673587737061 1.0 0.6809514876738593 2 Q12770 1 +Positive regulation of cholesterol metabolic process 0.9044259140474668 1.4018255099373522 0.1609673587737061 1.0 0.6809514876738593 2 Q12770 1 +Positive regulation of cholesterol biosynthetic process 0.9044259140474668 1.4018255099373522 0.1609673587737061 1.0 0.6809514876738593 2 Q12770 1 +Regulation of hormone biosynthetic process 0.9044259140474656 1.4018255099373471 0.1609673587737077 1.0 0.6809514876738593 2 P05023 1 +Regulation of steroid hormone biosynthetic process 0.9044259140474656 1.4018255099373471 0.1609673587737077 1.0 0.6809514876738593 2 P05023 1 +Cellular homeostasis 0.4378567013237165 1.4015212306042293 0.1610582633797168 1.0 0.6809514876738593 148 Q9Y487,P0CG08,O75027,P20020,Q9UM00,Q04656,Q9HD20,O75880,Q15907,O95202,P16615,P98194,Q9BWH2,P02792,P50897,P23634,Q8TAD4,Q12846,Q8N5M9,Q9H3K6,Q9UQN3,Q9NWS0,Q15904,O75503,Q9NQC3,Q9Y4W6,P05023,P52789,O00459,Q15043,P06576,Q16891,P51572,Q96TC7,P35670,Q93050,O43819,Q07820,Q9BPX6,Q8NE86,P07686,P62995,P09622,Q05086,Q92544,P13473,P10253,P09601,O76024,Q96HE7,P51790,Q4KMQ2,P02786,O75787,Q9Y6M7,Q96A33,Q8IYU8 57 +Negative regulation of receptor internalization 0.6225227282473891 1.3986883534884087 0.1619064582226466 1.0 0.6834165547616677 7 Q8IZ07,Q9UHD9 2 +Lipid catabolic process 0.3710149306645431 1.3969061738558868 0.1624417877976414 1.0 0.6834165547616677 78 Q13011,P04062,Q8N2A8,P23786,P50416,P06280,Q13510,P50897,Q8NHP8,P17900,Q9H6V9,Q9NZC3,Q8WTV0,P38571,O95470,Q8NCG7,P04066,Q9BWD1,Q8NCC3,P06865,Q15067 21 +Positive regulation of heart rate 0.8873920909258617 1.395941232312503 0.1627321928345839 1.0 0.6834165547616677 3 P00813 1 +Amine transport 0.6212822856380524 1.3924601077285417 0.1637831136717866 1.0 0.6840512596675105 7 O75915,Q15041,P55011,P05556 4 +Cotranslational protein targeting to membrane 0.5129262159612737 1.39224832527033 0.1638472135923283 1.0 0.6840512596675105 14 P43307,Q9UNL2,Q99442,Q15041,Q15629 5 +Purine ribonucleoside metabolic process 0.5915087687622442 1.3921413183700713 0.1638796084195899 1.0 0.6840512596675105 8 P00813 1 +Ribonucleoside metabolic process 0.5915087687622442 1.3921413183700713 0.1638796084195899 1.0 0.6840512596675105 8 P00813 1 +Endothelial cell proliferation 0.4745083618102396 1.3912699912308732 0.1641435700778879 1.0 0.6840512596675105 18 P09601,Q8WTV0 2 +Regulation of mitochondrial fusion 0.6208400335250974 1.3902389481450557 0.1644563300283033 1.0 0.6846487122737431 7 Q96E52,Q8N2A8,Q9Y6C9,Q9H6R6 4 +Positive regulation of nitric oxide synthase activity 0.900577293136636 1.3858694016700843 0.1657867855892165 1.0 0.6868510435011556 2 Q8WTV0 1 +Negative regulation of oxidoreductase activity 0.7293629900129885 1.38468859160714 0.1661477089819911 1.0 0.6868510435011556 4 P06280,Q15070 2 +Regulation of triglyceride metabolic process 0.8845043310875853 1.3846387478697413 0.1661629570798988 1.0 0.6868510435011556 3 Q96N66,Q8WTV0 2 +Nucleus organization 0.3586685567470015 1.376034623237198 0.1688109142245899 1.0 0.6888249246675285 68 Q86XL3,O94901,P50402,Q9Y3E7,Q7Z3B4,Q9Y2U8,P02545,Q8NC56,Q8N1F7,Q9H6H4,Q9UQN3,Q9ULX6,Q9NQC3,Q8NFH5,Q8IXJ6,O14657,Q9UH99,Q9BTX1,Q9BTV4,O75844,P20700 21 +Gpi anchor metabolic process 0.6629720530049892 1.3744162313765496 0.1693124999411954 1.0 0.6891626914982762 5 Q5H8A4,Q92643,Q96S52 3 +Vesicle targeting rough er to cis golgi 0.5582366791529142 1.3741223716355115 0.1694036952243756 1.0 0.6891626914982762 10 Q15363,P49755,Q9NR31 3 +Gland development 0.3616982433898731 1.3735833249303446 0.1695710766263225 1.0 0.6891968351875863 71 P52789,Q9NQC3,Q04656,P00813,Q99623,P09601,Q13505,P30536,P35670,Q9NZJ7,Q14118,O75844,Q9UGP8,P00403,P50416 15 +Lung alveolus development 0.6624904463093123 1.372181063259603 0.170007078984343 1.0 0.6902351199289276 5 P00813,O60476,Q04656 3 +Regulation of g protein coupled receptor signaling pathway 0.4801906370127918 1.366579883613079 0.1717570261171253 1.0 0.696034090856665 17 P04899,Q9UHD9,P35232,Q15043,P00813,P49840,P23634,Q8TEY7 8 +Fatty acid transport 0.497088920630393 1.3660607458792176 0.1719198977377518 1.0 0.6961605725834827 15 P50416,O43772,P23786,O43808 4 +Reactive nitrogen species metabolic process 0.4709882573727228 1.3657969479496277 0.1720027046247545 1.0 0.6961605725834827 18 P06280,P16435,Q08722,P30536,O43169 5 +Cellular response to unfolded protein 0.4326756562948166 1.3616634539804429 0.1733041198089706 1.0 0.6967979178978954 26 Q15363,P57088,Q96HY6,P48723,Q9BUN8,O76024,P18031,Q9Y4P3 8 +Vesicle targeting 0.4508441696101867 1.360024580436792 0.1738221455552668 1.0 0.6967979178978954 20 Q9UBV8,Q15363,Q9NR31,O95721,P49755,O95772 6 +Appendage morphogenesis 0.5398567650455834 1.358224046349857 0.1743926026311519 1.0 0.6967979178978954 11 Q9NX62 1 +Response to endoplasmic reticulum stress 0.3728588016972858 1.355398542096404 0.175290613891397 1.0 0.6967979178978954 83 P41440,Q15363,Q9UM00,Q9UBV2,P18031,P16615,Q96CS3,Q9UHD9,O75477,Q96HY6,Q13217,P27824,O00459,O95831,O60313,O94905,O43765,P51572,Q9Y4P3,Q9H3N1,O75955,P57088,P46379,Q9BUN8,O76024,Q96HE7,Q8TCT9,Q96A33 28 +Regulation of mammary gland epithelial cell proliferation 0.8766450130435426 1.3538790568742665 0.1757749661630583 1.0 0.6974229207391541 3 Q9NQC3 1 +Alcohol catabolic process 0.5285806509189251 1.3518097378575022 0.1764361881830474 1.0 0.6984291059050877 12 Q8WTV0,Q10713,Q9NX62 3 +Protein o linked glycosylation 0.4949053392703519 1.3514579767827544 0.1765487726536505 1.0 0.6984488921800728 15 O43505,Q10472 2 +Polyol catabolic process 0.583569498303357 1.350065646188925 0.1769949266994426 1.0 0.6997874933817182 8 Q10713 1 +Xenobiotic export 0.8906350224502937 1.3446802840838132 0.1787285042659774 1.0 0.7049243315277797 2 P08183 1 +Regulation of amino acid transport 0.6564411949468011 1.344088563368936 0.1789197499065227 1.0 0.7052501617444721 5 O75915,Q15041,P05556 3 +Negative regulation of leukocyte mediated immunity 0.6312733789019845 1.34021042125279 0.1801769444963732 1.0 0.707573922456564 6 P04439,P09601,P46108 3 +Response to zinc ion 0.6106948745514128 1.339200274337841 0.1805054831609205 1.0 0.7075914093590918 7 Q8TAD4,P30536,Q04656 3 +Protein insertion into er membrane by stop transfer membrane anchor sequence 0.6106350181286884 1.3388986761494168 0.1806036607067183 1.0 0.7075914093590918 7 Q15006,Q9NPA0,Q8N4V1 3 +Positive regulation of neural precursor cell proliferation 0.6546296297530261 1.3356697349381983 0.181657245830294 1.0 0.7093350325707566 5 P48681,P55209 2 +Proton transporting two sector atpase complex assembly 0.7157890498665033 1.3261067556060404 0.1848043387674112 1.0 0.7144061650297203 4 Q9BUB7,Q15070 2 +Ribonucleoside triphosphate biosynthetic process 0.4167383917030156 1.3242547497161177 0.1854184532333032 1.0 0.7144061650297203 29 P24539,O75746,Q9UJS0,P00403,P56385,P00846,O75964 7 +Carnitine metabolic process 0.6278072024397245 1.3234177676713337 0.1856964863045107 1.0 0.7144061650297203 6 P16435,P23786,P50416 3 +Positive regulation of cell killing 0.6272345564925245 1.3206421933696608 0.186620697131183 1.0 0.7144061650297203 6 P04439,P01889,O15400,P11279 4 +Positive regulation of triglyceride metabolic process 0.8842206542655673 1.318136143464918 0.1874580771578493 1.0 0.7144061650297203 2 Q8WTV0 1 +Glutamate receptor signaling pathway 0.8842206542655638 1.3181361434649037 0.1874580771578542 1.0 0.7144061650297203 2 Q92542 1 +Response to oxidative stress 0.380939439569517 1.317234246065463 0.1877601180165151 1.0 0.7144061650297203 94 P28074,Q99720,Q6NUK1,Q8N0U8,Q13546,P07237,P06493,Q16134,Q15118,Q8TED1,P36639,Q04656,P04062,Q15392,O43169,P16615,O75569,P30519,P23246,P00374,Q12846,O43464,O75306,Q9NR28,Q8IXJ6,O95831,P46108,Q15165,Q07820,Q05086,P27361,Q15233,P09601,Q96HE7,Q7Z2K6,O95168,O75915 37 +Striated muscle adaptation 0.7132683468945024 1.3152204408544437 0.1884358272884403 1.0 0.7144061650297203 4 P23634,P16615 2 +Toll like receptor 3 signaling pathway 0.7132404827270898 1.3151000919765032 0.1884762657044909 1.0 0.7144061650297203 4 P41440,O75955 2 +Eye photoreceptor cell development 0.7131172715484391 1.3145679247158362 0.1886551559136275 1.0 0.7144061650297203 4 P54802 1 +B cell activation involved in immune response 0.4812042046493111 1.3138365502348437 0.1889012147101294 1.0 0.7144061650297203 16 O96028,Q96FZ2,Q9UQ84,P00813 4 +Neutral amino acid transport 0.6491307877363617 1.310099804199799 0.190162074683351 1.0 0.7144061650297203 5 Q9H9B4,Q96NB2,P08195 3 +Cell maturation 0.4360740213542027 1.3084519395397831 0.190720065585108 1.0 0.7144061650297203 23 O75503,Q15645,P09622,P04062,Q9NZJ7,Q8N2A8 6 +Azole transmembrane transport 0.8816549069916755 1.3075262282857414 0.1910340531290821 1.0 0.7144061650297203 2 P30825 1 +Quaternary ammonium group transport 0.881654906991661 1.3075262282856812 0.1910340531291026 1.0 0.7144061650297203 2 O43772 1 +Response to salt 0.7113338483733398 1.3068646129182937 0.1912586962688447 1.0 0.7144061650297203 4 P07196 1 +Negative regulation of cholesterol metabolic process 0.8646134103304443 1.306804759881827 0.1912790281949261 1.0 0.7144061650297203 3 O94905,Q12770 2 +Negative regulation of alcohol biosynthetic process 0.8646134103304443 1.306804759881827 0.1912790281949261 1.0 0.7144061650297203 3 O94905,Q12770 2 +Heart process 0.4012126292140868 1.3067681709354722 0.1912914581513145 1.0 0.7144061650297203 33 P16615,P20020,P05023,Q6PI78,P10253,P00813,P78310,O75844 8 +Embryonic appendage morphogenesis 0.5460626872786924 1.3046994051497915 0.191995224127063 1.0 0.7144061650297203 10 Q9NX62 1 +Retrograde trans synaptic signaling 0.8806927517639522 1.303548752301563 0.1923874836362735 1.0 0.7144061650297203 2 Q8NCG7 1 +Chloride transport 0.5292466833761567 1.2953299018758082 0.1952064482275208 1.0 0.7157006233699664 11 P08183,Q9NW15,Q9UHG3,P30536 4 +Protein containing complex remodeling 0.8784477228993077 1.2942707382797896 0.1955719201876649 1.0 0.7157006233699664 2 Q8WTV0 1 +Embryonic heart tube development 0.6217281328316104 1.2939356219182574 0.1956876588744129 1.0 0.7157207219226418 6 P42892 1 +Response to mitochondrial depolarisation 0.5582792236078257 1.2908108971655736 0.1967692581961371 1.0 0.7188666427739573 9 Q709C8,P52789,Q13501,P04062,O95140 5 +Protein localization to golgi apparatus 0.5278514988399865 1.28704140428693 0.1980798570922444 1.0 0.7220294397770077 11 P83436,Q709C8,Q8TD16,P49755,Q9H4A6 5 +Rig i signaling pathway 0.5423831327183214 1.2836591283171763 0.1992612511562947 1.0 0.7230774644897895 10 Q99623 1 +Regulation of tor signaling 0.4767790042397082 1.283349129259834 0.1993697876519906 1.0 0.7230774644897895 16 P04062,O75844,Q9H4A6 3 +Polyol biosynthetic process 0.5169796879001636 1.2809879577763184 0.2001978958966694 1.0 0.7240902359689811 12 O15269,P04062,Q13510 3 +Response to corticosterone 0.874599101988464 1.2783750918475634 0.2011172022125289 1.0 0.7256625306587965 2 P07196 1 +Positive regulation of lymphocyte mediated immunity 0.4760089031540986 1.2780375997948787 0.2012361690623711 1.0 0.7256625306587965 16 P04439,P01889,O15400,Q96FZ2,O96028,P11279,P02786 7 +Negative regulation of blood circulation 0.8572012747406568 1.2778222424158303 0.2013121099378454 1.0 0.7256625306587965 3 P16615 1 +Negative regulation of amyloid fibril formation 0.6419778947232611 1.276807930595658 0.2016700649847322 1.0 0.7261464569500177 5 O15212,Q9UHV9 2 +Regulation of amyloid fibril formation 0.6419778947232611 1.276807930595658 0.2016700649847322 1.0 0.7261464569500177 5 O15212,Q9UHV9 2 +T cell mediated cytotoxicity 0.6179313603387384 1.27550382354761 0.2021309716733881 1.0 0.7261879256677565 6 P04439,Q9NUQ9,P01889,O15400 4 +Retina homeostasis 0.6414790970468387 1.274485239064521 0.2024915006483025 1.0 0.7261879256677565 5 Q15555,P51790 2 +Maternal placenta development 0.7033659711886004 1.2724402591601671 0.2032167375124782 1.0 0.7261879256677565 4 Q15363 1 +Protein quality control for misfolded or incompletely synthesized proteins 0.5052372393202719 1.2722526755529429 0.2032833572260275 1.0 0.7261879256677565 13 Q96E52,Q9Y679,P46379,Q9BUN8,Q16740 5 +Negative regulation of autophagy 0.4184536625202176 1.271875397418324 0.2034173944922748 1.0 0.7261879256677565 27 Q8IXJ6,Q9NRR5,O15118,P09601,P30536,Q07820,P10619 7 +Cellular response to iron ion 0.8726747915330475 1.2704320630502763 0.2039307681959066 1.0 0.7261879256677565 2 P09601 1 +Copper ion transmembrane transport 0.8726747915330345 1.2704320630502226 0.2039307681959257 1.0 0.7261879256677565 2 P35670 1 +Copper ion import 0.8726747915330345 1.2704320630502226 0.2039307681959257 1.0 0.7261879256677565 2 P35670 1 +Pinocytosis 0.5967898628035895 1.2690027846138108 0.2044400708969367 1.0 0.7261879256677565 7 P50897,Q9Y5X3 2 +Regulation of monocyte chemotaxis 0.7023341409386992 1.2679816959702737 0.2048044872447594 1.0 0.7261879256677565 4 Q8NHP6 1 +Postsynaptic cytoskeleton organization 0.7022892532342526 1.2677877330594585 0.2048737640246183 1.0 0.7261879256677565 4 P07196 1 +Selective autophagy 0.4142399611049467 1.2676429409800525 0.2049254898064278 1.0 0.7261879256677565 28 O43464,Q709C8,P12235,Q9Y679,Q96HY6,Q13501,Q99623,O95140,P05141,O15269,P21796,Q9Y6I9 12 +Vesicle targeting to from or within golgi 0.5146885764107576 1.2669651973475553 0.2051677344042155 1.0 0.7266497172679581 12 Q9UBV8,Q15363,Q9BVK6,Q9HCU5,Q9NR31,P49755 6 +Amyloid beta clearance 0.539272995434824 1.265855792422202 0.2055647160132676 1.0 0.7272621996502091 10 Q15907,Q16850 2 +Membrane organization 0.4870426755193431 1.2642015130911242 0.2061577078976055 1.0 0.7285660531688923 231 P41440,Q9UBV8,Q8N4V1,Q15006,O94901,Q9NS69,Q9P2W9,Q9UQB8,Q13190,Q9NVH1,Q5JRA6,P50897,P45880,Q9Y3E7,Q13505,P02545,Q12846,Q14185,Q8N1F7,P12235,Q9NQC3,Q9Y4W6,Q5JTV8,Q15070,O43765,O95249,O60499,O75844,Q96A33,Q5XKP0,O15400,Q15363,O15118,Q9P0J0,P50402,P16615,Q9BUR5,Q53H12,Q8NHH9,Q9NZD2,P08183,Q6UXV4,O60313,O95721,Q16891,O43760,P49755,Q9H4A6,Q9NZJ7,Q12981,Q96E52,Q9Y276,Q96GC9,Q86XL3,Q9NPA0,Q15041,O95202,Q12770,P98194,Q9Y2U8,Q00765,Q15629,Q9Y512,P52789,O14657,P30536,O75431,Q9Y371,Q9H3K2,P51790,Q9BZG1,Q15392,Q3ZCQ8,Q9BSR8,Q9NR31,O43752,Q8NC56,Q9NX63,Q9H6H4,Q9UQN3,Q9ULX6,Q8IXJ6,Q9Y5J9,Q9UH99,Q9BTV4,P20700,O14737,O43681,P57088,P46379,O95140 91 +Response to progesterone 0.6390296251119454 1.2630771887003824 0.2065614410181253 1.0 0.7289765420587521 5 P30536 1 +Antigen processing and presentation of endogenous peptide antigen 0.638774411893446 1.261888398399447 0.2069889472199859 1.0 0.7295180485082241 5 P10321,P04439,Q9NZ08 3 +Antigen processing and presentation of endogenous antigen 0.638774411893446 1.261888398399447 0.2069889472199859 1.0 0.7295180485082241 5 P10321,P04439,Q9NZ08 3 +Regulation of protein complex stability 0.7007115712488592 1.26097037054761 0.2073195224809811 1.0 0.7298906398842352 4 Q9BQ95,Q969V3 2 +Regulation of protein lipidation 0.6381689379625846 1.2590679594572622 0.2080057861722459 1.0 0.7316570517739319 5 P04062 1 +Neurofilament cytoskeleton organization 0.8697883258499142 1.2585239052031123 0.2082023474106766 1.0 0.7316570517739319 2 P07196 1 +Regulation of secretion 0.3680481072266213 1.2580306678095123 0.2083806653931874 1.0 0.7316570517739319 86 P61026,P11279,P50416,P16615,P04035,Q9Y3E7,Q4J6C6,Q12846,Q8N5M9,P00813,O00560,P49755,Q9H4A6,Q8NE86,Q92783,Q32P28,Q9Y5X3,Q16850,Q9P253,P09601,Q96KC8 21 +Regulation of translational initiation by eif2 alpha phosphorylation 0.6998844690157692 1.2573963043391374 0.2086101667950628 1.0 0.7316570517739319 4 Q15363 1 +Lipid translocation 0.6997208687671699 1.2566893534892791 0.2088661447857125 1.0 0.7317641726653241 4 P08183,Q96GC9 2 +Phosphatidylinositol dephosphorylation 0.8516197395635992 1.2560110201705488 0.2091119746160947 1.0 0.7318355467426886 3 Q10713 1 +Phospholipid dephosphorylation 0.8516197395635992 1.2560110201705488 0.2091119746160947 1.0 0.7318355467426886 3 Q10713 1 +Nervous system process 0.3795962773287845 1.2520916053633202 0.2105364862260972 1.0 0.7328701708202805 98 O14773,P04062,Q9BPZ3,Q14108,P04035,O75746,P50897,Q92542,P23634,Q9H6K4,P07196,Q9UQN3,Q11206,P17900,O60313,Q9Y6M9,Q6P4Q7,Q9Y5J9,O43924,Q14168,O75844,Q13641,P10253,O76024,Q14118,O00264 26 +Ire1 mediated unfolded protein response 0.6127617876591425 1.250387358950865 0.2111580800729582 1.0 0.7334608110399384 6 P57088,Q96HY6 2 +Synaptonemal complex organization 0.592212984769669 1.2458430919631536 0.2128220058813106 1.0 0.7368749131634499 7 Q15645,Q92791 2 +Regulation of macroautophagy 0.367858851060632 1.244475136206444 0.2133247447244055 1.0 0.7374356990153572 54 Q9Y487,Q9UHD9,Q9Y5X3,O15118,P04062,P09601,O15269,P21796,Q93050 9 +Response to iron ion 0.5912630886480182 1.241033478620294 0.2145933815946588 1.0 0.73774741435976 7 P09601,Q04656 2 +Interferon gamma production 0.56303805937352 1.2407879713960075 0.214684085943964 1.0 0.73774741435976 8 P04439,Q08722,Q9NUQ9,Q5ZPR3 4 +Copi coated vesicle budding 0.6953438581945244 1.2377753472212685 0.2157993719193909 1.0 0.7394888648789906 4 Q15363 1 +Endoplasmic reticulum unfolded protein response 0.4532146525985057 1.236501596744101 0.216272172570366 1.0 0.7397251762294723 18 P57088,Q15363,Q96HY6,Q9BUN8,O76024,P18031,Q9Y4P3 7 +Negative regulation of lymphocyte mediated immunity 0.6944801026957556 1.2340429465102518 0.2171869015096847 1.0 0.7404643563901486 4 P01889,P46108,P04439 3 +B cell activation 0.3934027668281664 1.2333069900887097 0.217461250944261 1.0 0.7404643563901486 33 Q5HYI8,P35232,P55327,Q96FZ2,Q9UQ84,O96028,P00813,P05556,Q99623 9 +Notch signaling pathway 0.4694552897372304 1.2327689779447697 0.2176619684450809 1.0 0.7404643563901486 16 Q9UBV2,P57105 2 +Peptidyl asparagine modification 0.5612008476337267 1.230981298744649 0.2183298588258262 1.0 0.7413166545487782 8 P46977,P04843 2 +Phagosome maturation 0.693196405648267 1.2284960272821135 0.2192608198040373 1.0 0.7429234040541808 4 Q9BZG1,P61106,Q9NVJ2 3 +Phagolysosome assembly 0.693196405648267 1.2284960272821135 0.2192608198040373 1.0 0.7429234040541808 4 Q9BZG1,P61106,Q9NVJ2 3 +Peroxisome organization 0.546927564568589 1.2281158666070628 0.2194034756264935 1.0 0.7429405408323921 9 Q9GZY8,O75381 2 +Associative learning 0.5324971866950579 1.2270127888428728 0.2198177842248936 1.0 0.7431513237275672 10 P50897,O00264,Q13641,P04035 4 +Positive regulation of b cell activation 0.5177292217976024 1.2267928852652474 0.2199004456070019 1.0 0.7431513237275672 11 P00813,Q96FZ2,O96028 3 +Response to manganese ion 0.6302173706428496 1.2220135964503354 0.2217024853723002 1.0 0.7457474274802968 5 P30536,Q04656 2 +Granulocyte migration 0.4507589270389348 1.218556812832263 0.2230124491249769 1.0 0.7478877611838278 18 Q8NE86,Q00013,P35613,P78310,Q8N5M9,Q8NHP6 6 +Erad pathway 0.387577758750499 1.2182073347530422 0.2231451930704058 1.0 0.7478877611838278 39 Q96CS3,P27824,Q9UHD9,O75477,O94905,Q9UBV2,O43765,P51572,P46379,Q9BUN8,O76024,Q8TCT9,Q96A33 13 +Negative regulation of protein secretion 0.5587202518136803 1.217734132584943 0.2233250218208664 1.0 0.7481042526630882 8 Q8N5M9,Q16850,P04035 3 +Male meiotic nuclear division 0.8414220956254076 1.216200580821908 0.2239085225251156 1.0 0.7492856331098198 3 Q9NY64 1 +Male meiosis i 0.8414220956254076 1.216200580821908 0.2239085225251156 1.0 0.7492856331098198 3 Q9NY64 1 +Cerebellar purkinje cell layer morphogenesis 0.6277116721458151 1.210332659350302 0.2261512704283568 1.0 0.7518045183876542 5 P04062 1 +Peptidyl glutamic acid modification 0.6275088795043142 1.2093872217626125 0.2265141155216037 1.0 0.7518045183876542 5 Q8N0U8 1 +Positive regulation of oxidoreductase activity 0.5565666017646488 1.2062274432535305 0.2277298051304388 1.0 0.7535279790554582 8 P16435,Q8WTV0,P00374 3 +Camera type eye morphogenesis 0.5841789608562953 1.2051346081704906 0.2281513414301974 1.0 0.7535754843277281 7 Q8NBN7,Q16706,P54802,O95140 4 +Negative regulation of endoplasmic reticulum stress induced eif2 alpha phosphorylation 0.8566388710712144 1.2043854647340453 0.2284406274117327 1.0 0.7535754843277281 2 Q15363 1 +Regulation of translation initiation in response to endoplasmic reticulum stress 0.8566388710712144 1.2043854647340453 0.2284406274117327 1.0 0.7535754843277281 2 Q15363 1 +Nuclear membrane organization 0.4200261145438805 1.202087596699275 0.2293295913782418 1.0 0.7541872130379323 24 Q8IXJ6,Q86XL3,Q9Y3E7,P50402,O14657,Q9BTV4,Q9H6H4,Q9UQN3,Q9ULX6 9 +Vesicle cargo loading 0.472506796644663 1.2008811680994813 0.2297973002424786 1.0 0.7541872130379323 15 Q15363,Q96PC5,Q9NR31,P49755,Q12770 5 +Glycolipid transport 0.8374338104431486 1.2006476625617206 0.2298879041055543 1.0 0.7541872130379323 3 Q9NZD2 1 +Energy derivation by oxidation of organic compounds 0.4017959394434703 1.2003329917214969 0.2300100415833177 1.0 0.7541872130379323 126 Q9NZ45,P04062,Q9UDW1,O14949,Q7KZN9,O75964,P13073,P14406,P24539,O95169,P14927,P21912,O96000,Q9UJS0,P00846,P20674,Q15070,P22695,Q9Y6M9,O43819,P56385,P00403,P09622,Q13423,P10253,Q9H3K2,O95168 27 +Nucleoside triphosphate biosynthetic process 0.3893786971330322 1.2001167706316858 0.2300939931641221 1.0 0.7541872130379323 34 P24539,O75746,Q9UJS0,P00403,P56385,P00846,O75964 7 +Positive regulation of amine transport 0.6251739927887504 1.198501140001858 0.2307219794648998 1.0 0.7541872130379323 5 Q15041,P05556 2 +Calcium mediated signaling 0.4299375676322572 1.1984452239403205 0.2307437355029085 1.0 0.7541872130379323 20 P16615,P00813,P23634,P51572,O75844 5 +Adult locomotory behavior 0.4830716007085948 1.1982466908866574 0.2308209932915632 1.0 0.7541872130379323 14 O75844,P50897,O15118 3 +Cerebellar purkinje cell layer formation 0.836809740322032 1.198214987507064 0.2308333321482396 1.0 0.7541872130379323 3 P04062 1 +Positive regulation of release of cytochrome c from mitochondria 0.6010059056346576 1.1931990849777083 0.2327914129500135 1.0 0.7587270021873731 6 Q96A26,Q9GZY8 2 +Regulation of tetrapyrrole metabolic process 0.8537524053880847 1.1925286207929018 0.2330540352439385 1.0 0.7587270021873731 2 O75027 1 +Regulation of b cell activation 0.4819119725270349 1.1906682439908156 0.2337838491831236 1.0 0.7592419954461426 14 O96028,Q96FZ2,P00813 3 +Vesicle fusion with golgi apparatus 0.6843277649952149 1.190180983077702 0.2339752659366596 1.0 0.7594173375919191 4 Q13190,Q9BSR8 2 +Positive regulation of lipid catabolic process 0.6834354053586735 1.1863267328182416 0.2354932934290665 1.0 0.7611275163398207 4 Q8NCG7,P50416 2 +Metal ion transport 0.38000166424691 1.185274579670878 0.2359089008138173 1.0 0.7611275163398207 104 Q8N668,O75027,Q8N4V1,Q9H9B4,P20020,Q96GC9,Q9UM00,Q04656,Q02790,Q9HD20,Q15907,P21796,O95202,P05026,P16615,P98194,P02792,P23634,Q8TAD4,Q9H0U3,Q9Y4W6,P05023,Q15043,P05556,Q6P4Q7,P30536,P35670,O75844,Q9BPX6,Q8NE86,O76024,Q96HE7,Q4KMQ2,P02786,Q9Y6M7,Q8IYU8 36 +Cytosolic calcium ion transport 0.4178369735782277 1.1840928956584995 0.2363762920729557 1.0 0.7611275163398207 24 P16615,Q9BPX6,P20020,Q9Y4W6,P23634,Q96HE7,P21796,O95202,Q8NE86 9 +Locomotory behavior 0.3968084388569968 1.182284962150771 0.2370926503614026 1.0 0.7611275163398207 30 P50897,P10253,O15118,Q04656,P51790,P54802,O75844 7 +Regulation of lipoprotein metabolic process 0.5974705810386964 1.1759856683074388 0.2396006031185005 1.0 0.7648712199090169 6 P04062 1 +Cellular response to extracellular stimulus 0.377633542058831 1.1728257735939875 0.2408656802767004 1.0 0.7653940266061376 44 P13473,Q9H773,P20020,P36639,Q9Y371,O95831,P04062,P09601,P21964 9 +Regulation of nitric oxide synthase activity 0.5966248054569945 1.1718668044000355 0.2412505364552593 1.0 0.7662419191132794 6 P06280,Q8WTV0,P00374 3 +Adrenergic receptor signaling pathway 0.6798683688226189 1.170922699376175 0.2416298500322247 1.0 0.7670713869971651 4 P23634,P04899 2 +Negative regulation of intrinsic apoptotic signaling pathway 0.3861448327501107 1.1693200642187471 0.2422747022621401 1.0 0.7671939921074462 34 P45880,O60313,Q9P0J0,O76024,Q07820 5 +Regulation of granulocyte chemotaxis 0.5360698603950125 1.167988688175118 0.2428113277601058 1.0 0.7671939921074462 9 Q8NHP6,Q00013,P27361,Q8NE86 4 +Positive regulation of t cell proliferation 0.5355586266463824 1.1651544057416463 0.2439564976212174 1.0 0.7671939921074462 9 P02786,P04439,P30825,Q5ZPR3 4 +Nuclear pore organization 0.4878838621031485 1.162479160203042 0.24504088496474 1.0 0.7677632360960871 13 Q9NQC3,Q8NFH5,Q7Z3B4,Q9BTX1,Q8N1F7 5 +Prostate gland growth 0.8454137267479278 1.158339001032157 0.2467257214401219 1.0 0.7703813443872686 2 Q9NZJ7 1 +Folic acid containing compound metabolic process 0.4661292932786888 1.1577833043518149 0.2469524783226555 1.0 0.7703813443872686 15 P41440,Q9H2D1,Q8IYS1,P00374 4 +Appendage development 0.4765485201140033 1.1555835780422616 0.2478515283231017 1.0 0.7703813443872686 14 Q9NX62 1 +Regulation of translation in response to endoplasmic reticulum stress 0.6762351241366228 1.155237816685488 0.2479930524946301 1.0 0.7703813443872686 4 Q15363 1 +Protein hydroxylation 0.4867154110937152 1.1550679717485357 0.2480625927242443 1.0 0.7703813443872686 13 O75718,P07237,Q32P28,Q92791,P13674,Q96HE7 6 +Organic hydroxy compound metabolic process 0.3821992883915328 1.1535270256992771 0.2486941313764881 1.0 0.7703813443872686 109 Q9Y394,O15118,Q04656,P04062,Q15392,O15269,Q12770,Q13510,Q14534,P04035,Q8NBN7,P51648,P16435,O75477,Q10713,Q9NX62,P00374,Q9BY49,P30837,Q9NZC3,O94905,P21964,P37268,O75845,Q8WTV0,P38571,Q16850,Q15800,P38435 29 +Regulation of blood circulation 0.3931620225991694 1.1492076045013566 0.2504703859312549 1.0 0.7724720881072242 30 P16615,P20020,P05023,Q6PI78,P10253,P00813,P78310,O75844,P42892 9 +Acylglycerol homeostasis 0.82404067204695 1.1485072617656713 0.2507592169453227 1.0 0.7729956488172058 3 Q8WTV0 1 +Response to activity 0.475278628470814 1.1472691786315428 0.2512703881576477 1.0 0.7732175691616527 14 Q9UDX5,O43819 2 +Antigen processing and presentation 0.4210846938005118 1.1469141411894606 0.2514171076084692 1.0 0.7732175691616527 21 P04439,P10321,P01889,Q9BZG1,Q9NZ08,P61026,Q06323,P04062,Q9NVJ2,Q9UIQ6,P20338,P61020 12 +Response to cold 0.5036040164534168 1.142430892937623 0.2532749562267775 1.0 0.7763272029387345 11 P20020,Q14011,P00403 3 +Endosomal transport 0.3504077679670813 1.1407959248068562 0.2539548568768979 1.0 0.7769438882397838 78 Q8NBN3,P61026,Q9BXI6,Q15907,Q13190,O15260,Q13501,Q9Y3E7,Q9H4M9,O43752,Q96D71,Q4J6C6,P49257,Q9UQN3,O60826,Q15904,O75503,O60749,Q9HD42,Q9H223,O60499,O95249,Q92783,Q9BVK6,Q9Y5X3,P78537 26 +Regulation of neurotransmitter levels 0.3839325854110363 1.1400511556007928 0.2542649895267308 1.0 0.7775262892169272 32 P16615,P41440,Q8NCG7,P50897,P05556,O95721,Q9P253,Q4J6C6,Q12846,P21964 10 +Dna unwinding involved in dna replication 0.4557445328801655 1.1377189669929095 0.2552378508485367 1.0 0.7793998719231892 16 Q9Y248 1 +Extracellular exosome assembly 0.6719575707467798 1.1367794920224974 0.2556304785860779 1.0 0.7802318133431208 4 O00560 1 +Neutrophil migration 0.4627371568036247 1.134827584619167 0.2564475660822618 1.0 0.7807587887719264 15 Q8NE86,P35613,P78310,Q8N5M9,Q8NHP6 5 +Autophagosome organization 0.3953883400060191 1.1346434928364242 0.2565247221889277 1.0 0.7807587887719264 29 P16615,Q9H0U4,Q9UHD9,Q96GC9,Q86Y82,Q9Y371,P04062,O95140,Q13099,O75396 10 +Muscle hypertrophy in response to stress 0.8193776066730836 1.1303912421760909 0.2583114027736011 1.0 0.7836250592552422 3 P23634,P16615 2 +Regulation of er associated ubiquitin dependent protein catabolic process 0.66963879001665 1.1267778597755636 0.259836413644722 1.0 0.7864139847932564 4 P51572,Q9UHD9 2 +Branching morphogenesis of a nerve 0.8357921744708358 1.119020867216829 0.2631312368577292 1.0 0.7917758643518971 2 Q9NQC3 1 +Negative regulation of synapse organization 0.8357921744708334 1.1190208672168194 0.2631312368577332 1.0 0.7917758643518971 2 O00264 1 +Folic acid transport 0.8354714560616018 1.1177129269248545 0.2636896199597878 1.0 0.7925338022124733 2 Q9H2D1 1 +Folate transmembrane transport 0.8354714560616018 1.1177129269248545 0.2636896199597878 1.0 0.7925338022124733 2 Q9H2D1 1 +Viral protein processing 0.5134059143017107 1.1172301080559577 0.2638959503921434 1.0 0.7927846622432113 10 Q10472,Q11206 2 +Magnesium ion transport 0.8158485723451834 1.1166958683817274 0.2641243850157322 1.0 0.7927846622432113 3 Q6P4Q7,Q8N4V1 2 +Smad protein signal transduction 0.5663915394162363 1.1148126161114162 0.2649307289841021 1.0 0.793436301561474 7 P08670,Q9UIQ6 2 +Fucose metabolic process 0.8147286658179537 1.1123526202709542 0.2659865674896036 1.0 0.7946547612252676 3 P04066 1 +Intermediate filament based process 0.4888437328802069 1.1081223655180945 0.2678089730994879 1.0 0.796216650814946 12 P07197,P08670,P07196,Q16352 4 +Regulation of the force of heart contraction 0.5835297453871156 1.1080696583765208 0.2678317334775886 1.0 0.796216650814946 6 P16615,P05023,P10253 3 +Positive regulation of glycoprotein metabolic process 0.5381848889843767 1.1078505244880072 0.2679263757065877 1.0 0.796216650814946 8 Q92542 1 +Lipid homeostasis 0.4084464108644532 1.106717417080716 0.2684161226516364 1.0 0.796216650814946 24 Q9Y6C9,Q5BJF2,Q8WTV0,Q9BWH2,Q9NQC3,O15118,O15260 7 +Regulation of autophagy of mitochondrion in response to mitochondrial depolarization 0.5378994932301355 1.1063213709329218 0.2685874449902932 1.0 0.796216650814946 8 P04062,Q709C8,O95140,P52789 4 +Microtubule anchoring 0.4883819021962234 1.105275199427406 0.2690403608319216 1.0 0.796216650814946 12 O95684,O75381,Q15154,Q8TD16,Q14118 5 +Cellular response to lipoprotein particle stimulus 0.8110362528071839 1.0980428634648598 0.2721857728195243 1.0 0.7995611027802548 3 Q5JRA6,O15118 2 +Negative regulation of anoikis 0.811036252807183 1.0980428634648558 0.272185772819526 1.0 0.7995611027802548 3 Q07820,Q9Y3E5 2 +Positive regulation of er associated ubiquitin dependent protein catabolic process 0.8103946102021095 1.09555786742307 0.2732723083755497 1.0 0.8005141165469175 3 P51572,Q9UHD9 2 +Positive regulation of anion transport 0.5613060238029779 1.0889565637786178 0.2761730407172456 1.0 0.8029860614939597 7 P08183,Q15041,P05556 3 +Golgi ribbon formation 0.5794885874554774 1.088378128003502 0.2764282127295299 1.0 0.8029860614939597 6 Q9Y3A6,Q9H4A6 2 +Granulocyte chemotaxis 0.4485957971131977 1.088011056886103 0.2765902263684472 1.0 0.8029860614939597 16 P27361,Q8NE86,Q00013,P35613,P78310,Q8NHP6 6 +Positive regulation of endoplasmic reticulum unfolded protein response 0.8280949326491343 1.0876819579595736 0.276735535298839 1.0 0.8029860614939597 2 P57088 1 +Positive regulation of ire1 mediated unfolded protein response 0.8280949326491343 1.0876819579595736 0.276735535298839 1.0 0.8029860614939597 2 P57088 1 +Regulation of perk mediated unfolded protein response 0.8280949326491343 1.0876819579595736 0.276735535298839 1.0 0.8029860614939597 2 P57088 1 +Calcium ion transmembrane transport 0.3735100442372149 1.087471526562518 0.2768284755436583 1.0 0.8029860614939597 40 P05026,P16615,P98194,Q9BPX6,P20020,Q9Y4W6,Q96GC9,Q8IYU8,Q9UM00,P23634,Q96HE7,Q4KMQ2,Q9UJZ1,P21796,O95202,Q8NE86 16 +Tail anchored membrane protein insertion into er membrane 0.494392731821431 1.0872809686742777 0.2769126567016489 1.0 0.8029860614939597 11 Q8N4V1,O43681,Q15006,O43765,P46379,Q9NPA0 6 +Negative regulation of vascular endothelial growth factor receptor signaling pathway 0.6602171542810948 1.086177749685664 0.2774003593266525 1.0 0.8029860614939597 4 P18031,O14964 2 +Regulation of vascular endothelial growth factor receptor signaling pathway 0.6602171542810948 1.086177749685664 0.2774003593266525 1.0 0.8029860614939597 4 P18031,O14964 2 +Zinc ion transport 0.8079234235637653 1.0859920612796896 0.2774825045312377 1.0 0.8029860614939597 3 Q8TAD4 1 +Adenylate cyclase activating g protein coupled receptor signaling pathway 0.5781962402739991 1.082081127826857 0.2792164807611927 1.0 0.8038462940583874 6 P23634,P04899 2 +Guanine nucleotide transmembrane transport 0.826170622193714 1.0798648394236132 0.2802023725209408 1.0 0.8045439196841875 2 P41440 1 +Guanine nucleotide transport 0.826170622193714 1.0798648394236132 0.2802023725209408 1.0 0.8045439196841875 2 P41440 1 +Cyclic gmp amp transmembrane import across plasma membrane 0.826170622193714 1.0798648394236132 0.2802023725209408 1.0 0.8045439196841875 2 P41440 1 +Blastocyst formation 0.4545316463665804 1.0792206960730095 0.280489355713621 1.0 0.8048418122839263 15 Q9NQC3 1 +Ganglioside catabolic process 0.8055822906640833 1.0769368923084597 0.2815084600195086 1.0 0.8063601240930385 3 P17900,P06865 2 +Ganglioside metabolic process 0.8055822906640833 1.0769368923084597 0.2815084600195086 1.0 0.8063601240930385 3 P17900,P06865 2 +Embryonic axis specification 0.5771075046946822 1.076776423827601 0.2815801604003263 1.0 0.8063601240930385 6 Q15363,Q8N2A8 2 +Positive regulation of protein exit from endoplasmic reticulum 0.8036573628488891 1.069497001496175 0.2848457792624781 1.0 0.811583437577342 3 P51572,Q9NR31 2 +Farnesyl diphosphate metabolic process 0.656100437440826 1.0684610424801833 0.2853125944527628 1.0 0.811583437577342 4 O95749 1 +Antigen processing and presentation of peptide antigen 0.5180545484899317 1.0679902420124443 0.2855249134836477 1.0 0.811583437577342 9 P10321,P04439,Q9UIQ6,Q9NZ08 4 +Activation of phospholipase c activity 0.8229634381013664 1.0668529177705697 0.2860382583464584 1.0 0.811583437577342 2 Q99623 1 +Regulation of phospholipase c activity 0.8229634381013664 1.0668529177705697 0.2860382583464584 1.0 0.811583437577342 2 Q99623 1 +Activation of protein kinase c activity 0.8229634381013664 1.0668529177705697 0.2860382583464584 1.0 0.811583437577342 2 Q99623 1 +Negative regulation of epithelial cell proliferation 0.4728106841781094 1.0667322857626858 0.2860927435992604 1.0 0.811583437577342 13 P57105 1 +Glycosylceramide catabolic process 0.8029191273392983 1.066645046869138 0.2861321507208263 1.0 0.811583437577342 3 P06280 1 +Glycosylceramide metabolic process 0.8029191273392983 1.066645046869138 0.2861321507208263 1.0 0.811583437577342 3 P06280 1 +Lysosomal membrane organization 0.8216805644644002 1.0616541339074537 0.2883927285578562 1.0 0.8143738989985222 2 Q9UQN3 1 +Regulation of autophagy 0.3640927494525288 1.060805997655497 0.2887780759798799 1.0 0.8151075083745132 98 O15269,Q9Y487,Q9UHD9,Q86UE4,Q9Y5X3,O15118,Q9H300,Q9NZ45,P04062,P09601,P30536,Q9NZJ7,Q93050,P21796,Q07820,O75844,P10619 17 +Peroxisomal transport 0.595561896316128 1.060469581718939 0.2889310213329783 1.0 0.8151847850906977 5 O75381 1 +Mitophagy 0.4439504467701414 1.0556691817037238 0.2911193817705297 1.0 0.8199336340365637 16 O43464,P12235,Q709C8,Q13501,Q99623,O95140,P21796 7 +Tripartite regional subdivision 0.7993996502175633 1.0530591714254671 0.2923138736983848 1.0 0.8208052197447726 3 Q8N2A8 1 +Negative regulation of muscle adaptation 0.8191148171905067 1.0512671543378191 0.2931359080052438 1.0 0.8213372096547469 2 P23634 1 +Regulation of cardiac muscle adaptation 0.8191148171905067 1.0512671543378191 0.2931359080052438 1.0 0.8213372096547469 2 P23634 1 +Negative regulation of cardiac muscle adaptation 0.8191148171905067 1.0512671543378191 0.2931359080052438 1.0 0.8213372096547469 2 P23634 1 +Chromosome attachment to the nuclear envelope 0.8191148171905065 1.0512671543378174 0.2931359080052447 1.0 0.8213372096547469 2 O94901 1 +Vacuolar localization 0.4275760899893628 1.0484228366643422 0.2944438365599326 1.0 0.8224218086855013 18 P51809,Q9BZG1,Q99584,P33176,P78537,Q6IAA8,P09601,Q86YV9,Q9NVJ2,Q9UNH7 10 +Cellular response to nutrient 0.5710500217459912 1.0472674467576304 0.2949762456072622 1.0 0.8224218086855013 6 P20020,P09601 2 +Regulation of protein exit from endoplasmic reticulum 0.5926589374013934 1.046956552658986 0.2951196171143584 1.0 0.8224218086855013 5 P51572,Q9NR31 2 +Regulation of leukocyte degranulation 0.5708655461324147 1.0463689615199314 0.2953907173293348 1.0 0.822684057015033 6 P09601,P11279 2 +Cholesterol efflux 0.5265720874871838 1.0456091810218526 0.2957415086975714 1.0 0.8229355585201732 8 Q8WTV0 1 +Negative regulation of macroautophagy 0.478499793586385 1.0443067308434932 0.2963434997674659 1.0 0.8229355585201732 12 P09601 1 +Positive regulation of wound healing 0.5263226750367074 1.044272176658421 0.296359481831403 1.0 0.8229355585201732 8 Q16625,Q11206,P05556 3 +Cell death in response to oxidative stress 0.3979269926884725 1.0425882957563113 0.2971390123178661 1.0 0.8229355585201732 25 O43464,Q99720,O75915,P07237,Q9NR28,Q15233,Q15118,P23246,P04062,Q07820,Q13546 11 +Regulation of amino acid transmembrane transport 0.7965992941931392 1.0422622234505088 0.2972901214931247 1.0 0.8229355585201732 3 Q15041,P05556 2 +L glutamate import across plasma membrane 0.7965992941931392 1.0422622234505088 0.2972901214931247 1.0 0.8229355585201732 3 Q15041,P05556 2 +Regulation of l glutamate import across plasma membrane 0.7965992941931392 1.0422622234505088 0.2972901214931247 1.0 0.8229355585201732 3 Q15041,P05556 2 +Regulation of protein localization to cell surface 0.4867225369792065 1.0413047882845616 0.2977341151255845 1.0 0.8229355585201732 11 Q8N668,Q15907,Q12846 3 +Dna methylation involved in gamete generation 0.8165490699166129 1.040894697028274 0.2979244231655116 1.0 0.8229355585201732 2 Q8N2A8 1 +Phosphatidylcholine biosynthetic process 0.5256690243493409 1.040768211399686 0.2979831368181509 1.0 0.8229355585201732 8 Q8NF37 1 +Response to topologically incorrect protein 0.3566724721135729 1.0402924097634247 0.2982040694940899 1.0 0.8229355585201732 50 Q13217,Q96CS3,Q15363,P57088,Q96HY6,P48723,O14657,P46379,Q9BUN8,O76024,Q96HE7,O95140,P18031,Q15629,Q9Y4P3 15 +Regulation of necrotic cell death 0.4776080114620394 1.038801443732519 0.298897089786069 1.0 0.8229355585201732 12 P00403,Q13510 2 +Collagen fibril organization 0.5122642750352068 1.0358174424380522 0.3002873186047394 1.0 0.8229355585201732 9 P13674,Q92791,Q04656 3 +Pteridine containing compound metabolic process 0.4175846919653162 1.035233060259984 0.3005600827700712 1.0 0.8229355585201732 19 P41440,Q9H2D1,Q8IYS1,P00374 4 +Response to retinoic acid 0.4767818406998659 1.0337008498845754 0.3012760356647788 1.0 0.8239061321524438 12 Q8TB36,P11717,Q9P0J0,Q99623,P02786 5 +Amino acid betaine metabolic process 0.5497443688525638 1.0301545566803547 0.3029374581912982 1.0 0.8259848713052954 7 P16435,P23786,P50416 3 +Regulation of collagen metabolic process 0.7928188698410735 1.0277057852092095 0.3040882456700062 1.0 0.827547300878101 3 P08670 1 +Negative regulation of amyloid beta clearance 0.792241200236083 1.0254834985731356 0.3051351076103907 1.0 0.827547300878101 3 Q16850 1 +Negative regulation of release of cytochrome c from mitochondria 0.5665623345215616 1.0254145460083297 0.3051676275881352 1.0 0.827547300878101 6 Q9H3K2,Q9H300,O60313 3 +Sodium ion transmembrane transport 0.4010194418533793 1.0242579160526664 0.3057134697456181 1.0 0.8276673472482821 23 Q8N668,P05026,P08195,P05023,P23634,Q6P4Q7,P54709,Q4KMQ2,Q9Y6M7 9 +Antigen processing and presentation of peptide antigen via mhc class i 0.5225418888955295 1.024005300817591 0.3058327711848414 1.0 0.8276673472482821 8 P10321,P04439,Q9UIQ6,Q9NZ08 4 +Cellular response to retinoic acid 0.5099714606774733 1.023076772474221 0.3062715482362543 1.0 0.8276673472482821 9 Q9P0J0 1 +Regulation of leukocyte mediated immunity 0.3826400850833039 1.0205090668640218 0.3074870913882739 1.0 0.8276673472482821 29 P04439,P01889,O15400,Q96FZ2,P02786,O96028,P09601,P46108,P11279,Q12846 10 +Growth plate cartilage development 0.7908981549298502 1.0203189488087638 0.3075772194436341 1.0 0.8276673472482821 3 O75844 1 +Bone growth 0.7908981549298502 1.0203189488087638 0.3075772194436341 1.0 0.8276673472482821 3 O75844 1 +Cell cell adhesion mediated by integrin 0.8107761385503773 1.0176123327705873 0.3088622240855307 1.0 0.8276673472482821 2 P00813 1 +Cellular response to low density lipoprotein particle stimulus 0.810776138550374 1.0176123327705726 0.3088622240855376 1.0 0.8276673472482821 2 O15118 1 +Germ cell migration 0.8107761385503609 1.0176123327705209 0.3088622240855623 1.0 0.8276673472482821 2 P78310 1 +Atp metabolic process 0.3747054359488857 1.0152062362824736 0.3100075284914516 1.0 0.8284829804838871 113 Q04656,Q9UDW1,O14949,Q7KZN9,O75964,P13073,P14406,P24539,O95169,P14927,O96000,Q9UJS0,P00846,P20674,P52789,P22695,Q9Y6M9,P30536,P56385,P00403,P09622,Q9BRR6,Q9H3K2,O95168 24 +Cellular modified amino acid catabolic process 0.5208445956482519 1.0149076393164094 0.3101498563242686 1.0 0.8284829804838871 8 Q9UHG3 1 +Regulation of exit from mitosis 0.5643283655536976 1.0145401130136769 0.3103250989178923 1.0 0.8284829804838871 6 Q99623 1 +Negative regulation of epithelial cell apoptotic process 0.5465348053291146 1.013831464972399 0.3106631784697262 1.0 0.8284829804838871 7 P09601 1 +Maintenance of protein localization in endoplasmic reticulum 0.8098139833226683 1.013739732755115 0.3107069595461198 1.0 0.8284829804838871 2 P24390 1 +Protein retention in er lumen 0.8098139833226683 1.013739732755115 0.3107069595461198 1.0 0.8284829804838871 2 P24390 1 +Angiogenesis involved in wound healing 0.7890808868322756 1.0133356428799094 0.3108998681731703 1.0 0.8284829804838871 3 P42785 1 +Cellular response to insulin like growth factor stimulus 0.809172546504169 1.011159275040923 0.3119402039792456 1.0 0.8284829804838871 2 Q96A49 1 +Positive regulation of skeletal muscle tissue development 0.6426038608029012 1.0105063805408003 0.3122527440537168 1.0 0.8284829804838871 4 P41440,O75955 2 +Positive regulation of muscle tissue development 0.6426038608029012 1.0105063805408003 0.3122527440537168 1.0 0.8284829804838871 4 P41440,O75955 2 +Maternal process involved in female pregnancy 0.5457899519606263 1.010043630481215 0.3124743870437443 1.0 0.8284829804838871 7 Q15363 1 +Chondroitin sulfate proteoglycan metabolic process 0.7879454465412563 1.0089753042416596 0.3129864780759646 1.0 0.8284829804838871 3 Q9NX62 1 +Regulation of nitric oxide metabolic process 0.4726876926876634 1.0084206562004807 0.3132525606242322 1.0 0.8284829804838871 12 P06280,Q08722,P30536 3 +Long chain fatty acid metabolic process 0.4014073891702519 1.008327541394704 0.3132972453924743 1.0 0.8284829804838871 22 P07099,P23786,Q9H7Z7,P50416 4 +Fibroblast proliferation 0.4724643766178129 1.0070416078511957 0.3139147797915869 1.0 0.8291836900623786 12 O75844 1 +Hydrogen peroxide biosynthetic process 0.787257899430176 1.0063360665911614 0.3142539366444277 1.0 0.8291836900623786 3 P00403 1 +Positive regulation of viral life cycle 0.562610664834333 1.0061808804078425 0.314328567659198 1.0 0.8291836900623786 6 P52292,Q9H9H4 2 +Lipoprotein biosynthetic process 0.4631014536516901 1.00494507336591 0.3149232989602715 1.0 0.8302387707966412 13 Q5HYI8,Q9H6R6,Q5H8A4,P04062,Q92643 5 +Photoreceptor cell maintenance 0.6405648267008849 1.001771045884008 0.3164541843173243 1.0 0.8315752010966958 4 Q15555,P11166,P51790 3 +Retinol metabolic process 0.5608021624128412 0.9973819901013312 0.3185791298264742 1.0 0.8332859431238802 6 Q9Y394,Q8NBN7 2 +Oligosaccharide catabolic process 0.805323925593355 0.9956984460629652 0.319396685367443 1.0 0.8342130252473359 2 P17900 1 +Neurotransmitter secretion 0.4038589888204865 0.9950651879215892 0.319704560507605 1.0 0.8342130252473359 20 P16615,P50897,O95721,Q9P253,Q4J6C6 5 +Positive regulation of protein kinase b signaling 0.4417918770917921 0.992735500184044 0.3208388698286892 1.0 0.8351587581907981 15 P35232,Q13641,Q9NQC3,Q86UE4 4 +Regulation of leukocyte proliferation 0.403395182984247 0.9914371227451282 0.3214721808596117 1.0 0.8352471820047231 20 P30825 1 +Regulation of syncytium formation by plasma membrane fusion 0.5799031752278507 0.98766711536629 0.3233157047458093 1.0 0.8352471820047231 5 P41440,O75955 2 +Positive regulation of syncytium formation by plasma membrane fusion 0.5799031752278507 0.98766711536629 0.3233157047458093 1.0 0.8352471820047231 5 P41440,O75955 2 +Regulation of myoblast fusion 0.5799031752278507 0.98766711536629 0.3233157047458093 1.0 0.8352471820047231 5 P41440,O75955 2 +Positive regulation of myoblast fusion 0.5799031752278507 0.98766711536629 0.3233157047458093 1.0 0.8352471820047231 5 P41440,O75955 2 +Cerebellar cortex development 0.4408631456383326 0.9864266936320628 0.3239237714330345 1.0 0.8352471820047231 15 P04062,O14949,P54802 3 +Positive regulation of amino acid transport 0.636412244910749 0.9840003229722346 0.3251153541014424 1.0 0.8352471820047231 4 Q15041,P05556 2 +Vascular process in circulatory system 0.3671423192419881 0.981350760561447 0.3264197989221007 1.0 0.8352471820047231 32 P08183,P20020,Q16625,P30825,P23634,Q9HB40,P42892 7 +Regulation of immune effector process 0.3608908685217118 0.9784981292371806 0.3278280161331128 1.0 0.8352471820047231 42 P51809,P04439,P01889,O15400,P35232,Q08722,Q96FZ2,P02786,O96028,Q99623,P09601,P46108,P11279,Q12846,Q9NUQ9,Q07021 16 +Lipopolysaccharide mediated signaling pathway 0.5138958458796671 0.9776715095670014 0.3282368170931988 1.0 0.8352471820047231 8 Q8WTV0 1 +Protein targeting to peroxisome 0.6341356112706646 0.9742692014022548 0.3299228925783877 1.0 0.8352471820047231 4 O75381 1 +Neutrophil chemotaxis 0.4577835714850744 0.9710892868455332 0.3315038181749921 1.0 0.8361005390800499 13 Q8NHP6,P35613,Q8NE86,P78310 4 +Peroxisome fission 0.7776899872803297 0.969698760364815 0.3321966685589039 1.0 0.8363083390968833 3 Q9GZY8 1 +Positive regulation of monocyte chemotaxis 0.7774505576531024 0.968784209051226 0.3326528669096975 1.0 0.8363083390968833 3 Q8NHP6 1 +Insulin processing 0.79858883899938 0.9687366207860006 0.3326766160534797 1.0 0.8363083390968833 2 Q8TAD4 1 +Cellular modified amino acid metabolic process 0.3396615781931578 0.966756517039656 0.333665766505671 1.0 0.836608362727386 56 Q9H7Z7,Q9H2D1,P16435,O60725,Q9BVG9,Q9NVH6,Q9UHG3,P00374,Q8NCC3,P23786,P50416 11 +Plasma membrane phospholipid scrambling 0.797947402180903 0.9661753942475462 0.3339564231067669 1.0 0.836608362727386 2 Q96GC9 1 +Negative regulation of cell volume 0.7979474021808883 0.9661753942474864 0.3339564231067968 1.0 0.836608362727386 2 P51790 1 +Negative regulation of cell growth 0.3827711008844494 0.9635868222065974 0.3352531161877745 1.0 0.8376964348270561 27 P50897,Q9NQC3 2 +Regulation of regulated secretory pathway 0.4080326944453722 0.9627684256477042 0.335663749276524 1.0 0.8376964348270561 19 P16615,Q9P253,P09601,P11279,Q4J6C6 5 +Bone remodeling 0.5110812458493095 0.962595933907462 0.3357503388587148 1.0 0.8376964348270561 8 O14773 1 +Regulation of histone h4 k16 acetylation 0.5744288059350029 0.9622784431640036 0.3359097544604659 1.0 0.8376964348270561 5 O75844 1 +Regulation of synaptic transmission dopaminergic 0.7966645285439378 0.9610564842278778 0.3365237680266424 1.0 0.8376964348270561 2 P41440 1 +Positive regulation of heterotypic cell cell adhesion 0.7966645285439378 0.9610564842278778 0.3365237680266424 1.0 0.8376964348270561 2 P41440 1 +Positive regulation of toll like receptor 3 signaling pathway 0.7966645285439378 0.9610564842278778 0.3365237680266424 1.0 0.8376964348270561 2 P41440 1 +Toll like receptor 4 signaling pathway 0.7966645285439378 0.9610564842278778 0.3365237680266424 1.0 0.8376964348270561 2 P41440 1 +Regulation of toll like receptor 4 signaling pathway 0.7966645285439378 0.9610564842278778 0.3365237680266424 1.0 0.8376964348270561 2 P41440 1 +Labyrinthine layer blood vessel development 0.6309368438127418 0.9606113868129256 0.3367476011723624 1.0 0.8377457695817577 4 Q15363 1 +Skeletal muscle cell differentiation 0.5359938283995158 0.960247401390906 0.3369307154001801 1.0 0.8377457695817577 7 P50402 1 +Positive regulation of fatty acid metabolic process 0.77479973782165 0.9586666773574612 0.3377266905797829 1.0 0.8379202012755049 3 P50416 1 +Immune response regulating signaling pathway 0.3460601700735252 0.95835292584356 0.3378848240528653 1.0 0.8379202012755049 52 Q9NQC3,P00813,O43657,Q99623,Q9NUD5 5 +Regulation of chondrocyte differentiation 0.5735732181213908 0.958314176810535 0.3379043571995181 1.0 0.8379202012755049 5 P16435 1 +Regulation of cartilage development 0.5735732181213908 0.958314176810535 0.3379043571995181 1.0 0.8379202012755049 5 P16435 1 +Purinergic nucleotide receptor signaling pathway 0.7741418030156979 0.9561577597891138 0.3389925369423985 1.0 0.8393363657088643 3 P00813,Q4KMQ2 2 +Cellular response to chemical stress 0.3376592602378645 0.9545702716213098 0.3397950568922518 1.0 0.8401773642151781 80 O75915,Q99720,Q6NUK1,Q8N0U8,P07237,P06493,Q15118,Q8TED1,Q04656,P04062,O95202,Q8TDW0,P16615,O75569,P23246,P00374,Q12846,O43464,Q9NR28,Q8IXJ6,O95831,P30536,Q07820,Q9BPX6,P27361,Q15233,P09601,Q7Z2K6,Q13546 29 +Sulfur compound catabolic process 0.4973813970559851 0.9531371547991035 0.3405205830553721 1.0 0.8404029682672157 9 P16278 1 +Lipid modification 0.3528100926117088 0.9523539650766816 0.3409174978214386 1.0 0.8408589711503722 47 Q13011,Q96N66,Q15067,P16435,Q53H12,Q9NTJ5,P04062,Q9BWD1,Q10713,P23786,Q11206,P50416 12 +Neuron projection guidance 0.3921506920909299 0.9518721620696684 0.3411618191635983 1.0 0.8408589711503722 23 Q15375,Q9BVA1,P35613,O75962,Q14118,O00264,P42892 7 +Homophilic cell adhesion via plasma membrane adhesion molecules 0.5512803026025728 0.951102343392776 0.3415524252699278 1.0 0.8409250148350971 6 P35613,P05556 2 +Intermembrane lipid transfer 0.5340256244192307 0.9502490804179664 0.3419857053191313 1.0 0.8410333865092889 7 Q9NZD2 1 +Positive regulation of mitochondrion organization 0.3839957621375882 0.9486689008803448 0.3427890358109167 1.0 0.8413559245687982 26 Q8NE86,O14737,Q96A26,Q9H6R6,Q9GZY8,Q8N2A8,P21796 7 +Negative regulation of mrna splicing via spliceosome 0.4283563138131699 0.94696525778148 0.3436564826796742 1.0 0.8421367695443103 16 P26368,Q13242,P38159,Q16629,P98175,P22626 6 +Sarcoplasmic reticulum calcium ion transport 0.533107353853167 0.9455853303230156 0.3443601293795557 1.0 0.8421367695443103 7 O75844 1 +Maintenance of protein location in mitochondrion 0.7710595779102136 0.944416540924118 0.3449568321082084 1.0 0.8421367695443103 3 P52789 1 +Reactive oxygen species metabolic process 0.3563827329337066 0.9421801061666656 0.3461004373128253 1.0 0.8427922126912462 43 Q15067,O75027,P52789,Q13423,Q9H300,P42785,Q04656,Q9P0J0,P30536,P51790,P00374,P00403 12 +Regulation of receptor localization to synapse 0.7702706807224753 0.9414146919679978 0.3464923874370682 1.0 0.8429347035715906 3 O15400 1 +Protein autoprocessing 0.5491159387200508 0.9405961008755612 0.3469118808185607 1.0 0.8431867953104066 6 Q9UG56,Q96E52,Q9Y4W6 3 +Macroautophagy 0.3637151796317005 0.9373541643346992 0.3485764099754136 1.0 0.8449767648813488 108 Q9Y487,Q9Y679,Q96GC9,O15118,P04062,Q99623,O15269,P21796,P16615,Q709C8,Q9UHD9,Q96HY6,Q13501,Q9Y3E7,Q13099,Q9UQN3,O43464,P12235,Q9H0U4,Q86Y82,Q9HD42,O95721,Q9H9H4,Q93050,P05141,Q8TBX8,Q92783,P27361,P13473,Q9NRR5,Q9Y5X3,Q9Y371,P09601,O95140,O75396,Q9Y6I9 36 +Regulation of exosomal secretion 0.4943557736282737 0.9363417780720608 0.3490972443233779 1.0 0.8449767648813488 9 Q92783,Q9Y3E7,O00560,O14964 4 +Regulation of natural killer cell mediated immunity 0.5684948028243173 0.9348069659221794 0.3498877890276559 1.0 0.8450815023686349 5 P04439,P46108,P11279 3 +Regulation of neutrophil chemotaxis 0.5309326523055202 0.9345431377668666 0.3500237948756917 1.0 0.8450815023686349 7 Q00013,Q8NE86,Q8NHP6 3 +Regulation of neutrophil migration 0.5309326523055202 0.9345431377668666 0.3500237948756917 1.0 0.8450815023686349 7 Q00013,Q8NE86,Q8NHP6 3 +Fatty acid elongation 0.7682693258709761 0.9338055242334866 0.3504042194097645 1.0 0.845579045590918 3 Q9P035 1 +Leukotriene biosynthetic process 0.7680461982675619 0.9329577519519252 0.3508417821344229 1.0 0.8456698911536109 3 P09960,Q99735 2 +Membrane raft organization 0.4806484310586459 0.9283430746172908 0.3532296369150196 1.0 0.8474468539813977 10 P50897 1 +Mitochondrial adp transmembrane transport 0.7667629130574232 0.9280841320201298 0.3533639300257807 1.0 0.8474468539813977 3 P12236,P12235 2 +Nucleobase transport 0.7667629130574016 0.928084132020048 0.3533639300258231 1.0 0.8474468539813977 3 P12235,Q9Y277 2 +Positive regulation of mitophagy 0.7667629130574019 0.928084132020048 0.3533639300258231 1.0 0.8474468539813977 3 P21796,P12235 2 +Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 0.432057250084058 0.9266063479571494 0.3541309578117722 1.0 0.8481462204321246 15 O95831,O60313,P46379,O76024,P18031 5 +Nerve development 0.5039438237608485 0.9243943366481904 0.3552810422595216 1.0 0.8501601645222316 8 Q9H061,P42892 2 +Mitochondrial protein catabolic process 0.787363694676094 0.9240918947173876 0.3554384729456163 1.0 0.8501667715810113 2 Q9UG56 1 +B cell differentiation 0.4583691625294137 0.9200095081393184 0.3575677905573666 1.0 0.8504990519751291 12 P55327,Q5HYI8,P00813,P05556 4 +Cellular response to biotic stimulus 0.3596394290112313 0.9188081845173356 0.3581959107708652 1.0 0.8504990519751291 35 Q8WTV0,Q86UE4,Q9UM00,P30536,O76024,P08670,O75844,Q96A33 8 +Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway 0.7641963426371582 0.9183484135225084 0.3584364887148501 1.0 0.8504990519751291 3 P10321,P04439 2 +Negative regulation of natural killer cell mediated immunity 0.7641963426371503 0.9183484135224804 0.3584364887148648 1.0 0.8504990519751291 3 P04439,P46108 2 +Detection of external biotic stimulus 0.764196342637132 0.9183484135224108 0.3584364887149012 1.0 0.8504990519751291 3 P04439,Q8WTV0 2 +Positive regulation of cell adhesion molecule production 0.763929893454 0.9173385925867532 0.3589652402297401 1.0 0.8504990519751291 3 P41440 1 +Positive regulation of fatty acid oxidation 0.7854393842206788 0.916477971637868 0.3594162560449314 1.0 0.8504990519751291 2 P50416 1 +Positive regulation of fatty acid beta oxidation 0.7854393842206788 0.916477971637868 0.3594162560449314 1.0 0.8504990519751291 2 P50416 1 +Response to light intensity 0.785439384220678 0.9164779716378646 0.3594162560449332 1.0 0.8504990519751291 2 Q8NBN7 1 +Negative regulation of organic acid transport 0.7854393842206533 0.9164779716377665 0.3594162560449847 1.0 0.8504990519751291 2 O75915 1 +Actin mediated cell contraction 0.4017777215970136 0.9152911910842814 0.3600387823330813 1.0 0.8504990519751291 19 P16615,Q9UM22 2 +Negative regulation of receptor binding 0.7851186658114421 0.915210164005944 0.3600813097998971 1.0 0.8504990519751291 2 P16615 1 +Transmembrane receptor protein tyrosine phosphatase signaling pathway 0.7851186658114166 0.9152101640058452 0.3600813097999491 1.0 0.8504990519751291 2 O75962 1 +Pyramidal neuron differentiation 0.563825233395835 0.9132304151884972 0.3611213706575009 1.0 0.8512708563211678 5 P04062,O14949 2 +Lipid storage 0.401152026114525 0.9105421439452112 0.3625366665630012 1.0 0.8529360405273496 19 P17900,Q8WTV0,Q14534,Q9H6V9,P50416 5 +Parkin mediated stimulation of mitophagy in response to mitochondrial depolarization 0.7838357921744699 0.9101423470365672 0.3627474442230456 1.0 0.8529360405273496 2 O95140 1 +Regulation of mrna export from nucleus 0.5631000692895861 0.9098832451679748 0.3628840867607061 1.0 0.8529484037836728 5 Q96ST2,Q08J23,Q9ULX6 3 +Cellular lipid metabolic process 0.4402377438948482 0.90789813055611 0.3639320454106969 1.0 0.853694360324158 205 Q13011,Q9Y394,Q9H7Z7,Q9BT22,Q9UG56,Q9NPH0,Q9NTJ5,O95749,Q9UBV2,Q99623,P04062,Q06136,Q86YN1,Q92643,O15269,P23786,Q12770,P50416,P06280,Q96N66,Q8NF37,A1L0T0,Q13510,P04035,O75477,Q8NBN7,P51648,P50897,Q53H12,P16435,P07099,Q9BVG9,Q9HB40,Q10713,Q9NX62,Q9NZD2,Q11206,Q8NHP8,P35790,O95674,P17900,Q99805,Q9P035,Q8IXJ6,Q8NBX0,Q9BY49,Q9NZC3,O94905,Q9NZJ7,Q9BV10,O75844,P37268,Q8WTV0,O95470,Q5H8A4,Q8NCG7,Q9H6U8,Q15800,P04066,Q9BWD1,P16278,O00116,Q8NCC3,P06865,Q15067,Q53GQ0 66 +Purine nucleoside catabolic process 0.7602217247986414 0.9033028849936576 0.3663651658010676 1.0 0.8547083352430462 3 P00813 1 +Serine transport 0.7600256657042013 0.9025617342663786 0.3667585431318607 1.0 0.8547083352430462 3 Q96NB2,Q9H9B4 2 +Regulation of electron transfer activity 0.7597048444016548 0.9013491611852704 0.3674027028566193 1.0 0.8547083352430462 3 Q99623,Q04656 2 +Regulation of t cell mediated immunity 0.5241326910126995 0.9000456606820487 0.3680959519248181 1.0 0.8547083352430462 7 P04439,P01889,O15400 3 +Sodium ion export across plasma membrane 0.7587423804940618 0.8977130072691674 0.3693385730990193 1.0 0.8547083352430462 3 P05026,P05023 2 +Negative regulation of bmp signaling pathway 0.6155439764309956 0.8951660930832254 0.3706983071963083 1.0 0.8553149157698214 4 Q9Y2U8 1 +Neuron projection regeneration 0.4747216374537841 0.8942057523132779 0.3712118150787749 1.0 0.8553149157698214 10 P07196,P30536,P00374 3 +Cellular response to dsrna 0.4865612816738852 0.8931145064154717 0.3717958552529938 1.0 0.8553149157698214 9 P41440,Q9NUD5 2 +Antigen processing and presentation of exogenous peptide antigen 0.7571457021608266 0.8916860522868763 0.3725612315545294 1.0 0.8555812704143925 3 Q9UIQ6 1 +Golgi vesicle transport 0.3860763635241752 0.8904902935188759 0.3732026780558244 1.0 0.8555812704143925 137 Q8N668,Q9BZG1,Q9UBV8,Q15363,Q96PC5,P61026,P61019,Q9P2W9,Q8TBA6,P11279,Q9Y3A6,Q13190,O15260,Q12770,P98194,Q5JRA6,Q709C8,Q9BSR8,Q969X5,Q8NHH9,Q9NR31,O15127,O43752,Q12907,Q4J6C6,Q5BJH7,Q7Z7H5,P49257,Q96JB2,P24390,O60826,O60749,P83436,Q9H0U4,Q6NUQ1,O60499,O95249,O15258,Q9Y282,P49755,Q9H4A6,P51572,O95070,Q12981,Q9BVK6,Q8TD16,O75396,Q9Y3B3,O14828 49 +Signal release 0.3414678126029186 0.8896087842593019 0.3736759878148963 1.0 0.8555812704143925 51 P16615,P50897,Q15907,Q8N5M9,P50416 5 +Cellular response to external stimulus 0.3426607622616828 0.8865339371501557 0.3753298749763638 1.0 0.8564579719352194 50 P13473,Q9H773,P36639,Q9Y371,O95831,P04062,P09601,Q14118,P21964 9 +Negative regulation of growth 0.3672657375848351 0.882334200747787 0.3775961067445528 1.0 0.8579788511668509 29 P50897,Q9NQC3 2 +Cellular carbohydrate metabolic process 0.3153789830586316 0.8821829841270987 0.3776778621490844 1.0 0.8579788511668509 64 O43505,Q14108,Q7LGA3,Q92520,P16278,Q10713,Q9NX62,O75844 8 +Protein retention in golgi apparatus 0.7545717035611135 0.8819840662709972 0.3777854238807037 1.0 0.8579788511668509 3 Q709C8,Q9H4A6 2 +Liver regeneration 0.472281423998829 0.8801621996392791 0.3787714477474273 1.0 0.8579788511668509 10 P09601 1 +Interleukin 12 production 0.535863967302622 0.8764134792066376 0.3808052932002597 1.0 0.8579788511668509 6 P01889,Q08722 2 +Mitotic nuclear membrane organization 0.5354842484469209 0.8745787177672109 0.3818031718262236 1.0 0.8579788511668509 6 Q86XL3,Q9H6H4 2 +Antigen processing and presentation of exogenous peptide antigen via mhc class i 0.7742142398973949 0.8723149974426888 0.3830365581698054 1.0 0.8579788511668509 2 Q9UIQ6 1 +Renal tubular secretion 0.7738935214881562 0.8710598173680206 0.383721492859729 1.0 0.8579788511668509 2 Q9Y5X3 1 +Positive regulation of renal sodium excretion 0.7738935214881562 0.8710598173680206 0.383721492859729 1.0 0.8579788511668509 2 Q9Y5X3 1 +Renal sodium excretion 0.7738935214881562 0.8710598173680206 0.383721492859729 1.0 0.8579788511668509 2 Q9Y5X3 1 +Regulation of renal system process 0.7738935214881562 0.8710598173680206 0.383721492859729 1.0 0.8579788511668509 2 Q9Y5X3 1 +Negative regulation of adenylate cyclase activating adrenergic receptor signaling pathway 0.7738935214881334 0.8710598173679316 0.3837214928597776 1.0 0.8579788511668509 2 P23634 1 +Adenylate cyclase activating adrenergic receptor signaling pathway involved in heart process 0.7738935214881334 0.8710598173679316 0.3837214928597776 1.0 0.8579788511668509 2 P23634 1 +Negative regulation of adenylate cyclase activating g protein coupled receptor signaling pathway 0.7738935214881334 0.8710598173679316 0.3837214928597776 1.0 0.8579788511668509 2 P23634 1 +Arachidonic acid metabolic process 0.5346497624276352 0.8705475327316575 0.3840012549391036 1.0 0.8579788511668509 6 P07099,Q9H7Z7 2 +Regulation of sulfur metabolic process 0.7510426692332203 0.8687113666700018 0.3850050226781074 1.0 0.8590721117239866 3 O75027,Q15120 2 +Protein o linked glycosylation via threonine 0.7732520846696862 0.8685506078045404 0.3850929802238485 1.0 0.8590721117239866 2 Q10472 1 +Chemical homeostasis 0.4204610464715064 0.8682951190877927 0.3852327934955835 1.0 0.8590721117239866 182 Q9Y487,Q5BJF2,O75027,P20020,Q9UM00,O15118,Q04656,P04062,Q9HD20,O75880,Q9Y6N1,Q15907,O95202,O15260,P16615,Q8NF37,P98194,Q9BWH2,P30519,P50897,P42785,P23634,Q8TAD4,Q8N5M9,Q9H3K6,Q9NWS0,Q15904,O75503,Q9P035,Q9NQC3,P52789,P05023,O00459,Q15043,P06576,Q6P4Q7,Q16891,P51572,Q96TC7,P30536,P35670,Q93050,O43819,Q9BPX6,Q8NE86,Q9Y6C9,Q05086,Q8WTV0,Q9Y5X3,P09601,O76024,O75787,P51790,Q9Y6M7,Q96A33,Q15067 56 +Regulation of fatty acid biosynthetic process 0.4928258951235653 0.8650058960677574 0.3870355526534896 1.0 0.8596082134199298 8 O75477,O94905,Q12770 3 +Regulation of receptor mediated endocytosis 0.3812923307541184 0.8631827516095333 0.3880369955400631 1.0 0.8598729153732761 23 P41440,Q9UHD9,P50897,O00560,Q8IZ07,O75955 6 +Learning 0.4022924451875315 0.8621377929742999 0.3886116965041886 1.0 0.8598729153732761 18 Q05086,P04035,P50897,P05556,O00264,Q13641 6 +Nucleoside metabolic process 0.3947085128145241 0.8616495697189828 0.3888803845639224 1.0 0.8601238272485513 19 O60725,P00813 2 +Sulfate transport 0.7487969201154706 0.8602831545157941 0.3896329764058928 1.0 0.8603732254513795 3 Q9UBX3,Q9H0H5 2 +Zinc ion homeostasis 0.5324566153172938 0.8599595140597728 0.389811360219896 1.0 0.8604744476530313 6 Q8TAD4,Q15043 2 +Positive regulation of cysteine type endopeptidase activity 0.3675431790130897 0.8567769982304158 0.3915681401181412 1.0 0.8628853922766371 28 Q9NR28,Q96A26,Q9BXI6,Q9BXK5,O95831,Q9P0J0,P51572,Q9NZJ7 8 +Negative regulation of neuron apoptotic process 0.3702903290589775 0.8550727848249494 0.3925108549602436 1.0 0.8630158445670344 27 P50897,P04062,P09601,O76024,P07196 5 +Regulation of heart rate 0.4476529968161422 0.8539321453150077 0.3931425872795704 1.0 0.8630158445670344 12 P00813 1 +Positive regulation of isotype switching 0.4888028678777695 0.8435646463285096 0.398912726974044 1.0 0.8638550968678822 8 Q96FZ2,O96028 2 +Positive regulation of b cell mediated immunity 0.4888028678777695 0.8435646463285096 0.398912726974044 1.0 0.8638550968678822 8 Q96FZ2,O96028 2 +Syncytium formation 0.5129442127324481 0.843415726666159 0.3989959794426554 1.0 0.8638550968678822 7 P41440,O75955,P05556 3 +Myoblast fusion 0.5129442127324481 0.843415726666159 0.3989959794426554 1.0 0.8638550968678822 7 P41440,O75955,P05556 3 +Epithelial cell proliferation 0.3467204103974674 0.8424311654119508 0.3995466544338402 1.0 0.8638550968678822 43 Q8WTV0,Q9NQC3,Q99623,P09601,P57105 5 +Positive regulation of t cell mediated immunity 0.5286786915395953 0.8417439758486583 0.399931277223386 1.0 0.8638550968678822 6 P04439,P01889,O15400 3 +Autophagosome maturation 0.3842455394567486 0.8416016850903102 0.4000109457515028 1.0 0.8638550968678822 20 P16615,P13473,Q9NRR5,Q96GC9,Q9Y3E7,O95721,Q9UQN3 7 +Morphogenesis of a branching structure 0.3994581142974753 0.8412708320936066 0.4001962270708881 1.0 0.8638550968678822 18 Q15363,Q99623,Q14118,Q9NQC3 4 +T cell apoptotic process 0.453326514604778 0.8411865105347451 0.4002434563197816 1.0 0.8638550968678822 11 P24390 1 +Deoxyribonucleoside triphosphate metabolic process 0.4882679776837862 0.8407162122227112 0.4005069359995483 1.0 0.8638550968678822 8 P00813 1 +Positive regulation of small molecule metabolic process 0.4283465502515047 0.8391616989912963 0.4013785769929121 1.0 0.8638550968678822 14 P50416,P16435,P00403,Q12770 4 +Sensory perception of mechanical stimulus 0.4125958799528126 0.8371410260203889 0.4025133020184694 1.0 0.8638550968678822 16 Q9Y6M9,P23634,Q14108,O76024 4 +Response to ether 0.6017814740191384 0.837125060948631 0.4025222749828794 1.0 0.8638550968678822 4 Q14103,Q9H4A6 2 +Eye photoreceptor cell differentiation 0.5468843972705051 0.8353324683928078 0.4035305412219805 1.0 0.8638550968678822 5 P54802 1 +Negative regulation of erk1 and erk2 cascade 0.436360255169712 0.834844693063099 0.4038051581356894 1.0 0.8638550968678822 13 P35232,Q99956,P57105,P18031 4 +Negative regulation of cell killing 0.600740137387869 0.8327547324406251 0.4049830694957521 1.0 0.8638550968678822 4 P04439,P46108 2 +Response to metal ion 0.324426650300313 0.8325154769630023 0.4051180458977144 1.0 0.8638550968678822 58 Q6NUK1,Q9UBV8,P06493,P36639,O15118,Q04656,P35613,O75746,Q92542,Q8TAD4,Q9UJS0,P09960,P35611,P30536,P35670,O75131,Q14168,O60888,P27361,P09601,P02786,Q14103 22 +Detection of other organism 0.7639512508017945 0.8323456310676945 0.4052138810796455 1.0 0.8638550968678822 2 P04439 1 +Protection from natural killer cell mediated cytotoxicity 0.7639512508017945 0.8323456310676945 0.4052138810796455 1.0 0.8638550968678822 2 P04439 1 +Mitochondrial proton transporting atp synthase complex assembly 0.7405935425681736 0.8296219594547429 0.4067525571398089 1.0 0.8638550968678822 3 Q15070 1 +Attachment of gpi anchor to protein 0.7404555662495942 0.8291080107803146 0.4070432911834574 1.0 0.8638550968678822 3 Q96S52,Q92643 2 +Insulin secretion 0.3725455090572892 0.8289817100629407 0.4071147568156932 1.0 0.8638550968678822 25 Q15907,P50416 2 +Positive regulation of histone phosphorylation 0.7629890955740855 0.8286200671053414 0.4073194292069346 1.0 0.8638550968678822 2 P50750 1 +Tissue remodeling 0.4112200545836184 0.8275681702626599 0.407915100520938 1.0 0.8638550968678822 16 O14773,Q92791,P38571 3 +Regulation of heterotypic cell cell adhesion 0.7391722810394565 0.8243307762922667 0.40975163602472 1.0 0.8638550968678822 3 P41440,O75955 2 +Regulation of toll like receptor 3 signaling pathway 0.7391722810394565 0.8243307762922667 0.40975163602472 1.0 0.8638550968678822 3 P41440,O75955 2 +Positive regulation of epithelial cell migration 0.3638718652828513 0.8243155442406315 0.4097602885929237 1.0 0.8638550968678822 28 Q8WTV0,Q9NQC3 2 +Regulation of adenylate cyclase activating g protein coupled receptor signaling pathway 0.7388514597369287 0.8231372856718422 0.4104299276615302 1.0 0.8638550968678822 3 P23634,P04899 2 +Establishment of protein localization to endoplasmic reticulum 0.3742028329606104 0.8231085057543476 0.4104462922675207 1.0 0.8638550968678822 24 O43681,P61026,Q9Y5M8,Q99442,Q9UNL2,Q15005,P46379,Q15629,Q9UGP8 9 +Regulation of cellular response to osmotic stress 0.5980815041696016 0.8216117237817755 0.4112979146954212 1.0 0.8638550968678822 4 O95202 1 +Cellular response to fatty acid 0.5438690781832112 0.8215416666386302 0.4113378007101305 1.0 0.8638550968678822 5 Q15120,P50416 2 +Primary amino compound metabolic process 0.7384207597862692 0.8215355526105862 0.4113412817519211 1.0 0.8638550968678822 3 Q9NZC3 1 +Long chain fatty acyl coa biosynthetic process 0.5084146967114908 0.8205502381517087 0.4119025021831892 1.0 0.8638550968678822 7 Q53GQ0 1 +Embryonic pattern specification 0.508325901868633 0.8201024003038141 0.4121577340030942 1.0 0.8638550968678822 7 Q15363,Q8N2A8 2 +Regulation of bone mineralization 0.5434624779627611 0.819684007204517 0.4123962693803702 1.0 0.8638550968678822 5 P20020,O75844 2 +Protein folding in endoplasmic reticulum 0.4729365012837765 0.8177662555844925 0.4134906697931435 1.0 0.8638550968678822 9 Q13217,P14625,P27824,P07237,Q96HE7 5 +Protein kinase b signaling 0.3710339648953636 0.8162611539147133 0.4143507869842304 1.0 0.8638550968678822 25 Q8IXJ6,Q86UE4,P35232,Q9NQC3,Q14118,Q8NC56,Q13641 7 +L serine transport 0.7597819114817175 0.8162295160362472 0.414368878362974 1.0 0.8638550968678822 2 Q9H9B4 1 +Lymphocyte mediated immunity 0.3486776009051259 0.8124709576748055 0.4165214446760763 1.0 0.864284775086404 35 P51809,P04439,P01889,O15400,P33176,P07437,Q96FZ2,Q9UQ84,O96028,P53634,P46108,P68371,P11279,Q9NVJ2,P02786,Q9NUQ9,Q07021 17 +Neurotransmitter transport 0.3624968925275194 0.812161057879438 0.4166992215065379 1.0 0.864284775086404 28 P16615,P41440,P50897,P05556,O95721,Q9P253,Q4J6C6,Q12846 8 +Camera type eye development 0.3562284318037277 0.8118834776766348 0.4168584959024273 1.0 0.8643389828804081 30 Q8NF37,O75569,P20020,Q8NBN7,P48681,P23634,Q16706,O95140,P54802,P08670 10 +Positive regulation of potassium ion import across plasma membrane 0.7584990378447709 0.8112855707981952 0.4172016943837082 1.0 0.8647743933394105 2 P05026 1 +Positive regulation of immune effector process 0.3488051349534308 0.8108547816344388 0.4174490705257447 1.0 0.8648792337577206 34 P04439,P01889,O15400,P35232,Q96FZ2,P02786,O96028,Q99623,P09601,P11279,Q12846 11 +Heterotypic cell cell adhesion 0.4601487972988976 0.8104815122586179 0.4176634864219739 1.0 0.8648792337577206 10 P78310,P41440,Q08722,P05556 4 +Regulation of endoplasmic reticulum unfolded protein response 0.5058321704623701 0.8075320913793788 0.4193599932981442 1.0 0.8666327923063571 7 P57088,Q96HY6,O76024 3 +Memory 0.505585305226788 0.8062884413678963 0.4200765536164241 1.0 0.8669371239967606 7 O00264 1 +Positive regulation of dna dependent dna replication 0.5402998840356756 0.8052514263692894 0.4206746056184385 1.0 0.8678168222672078 5 Q9UJZ1,O95785,Q04837 3 +Intra golgi vesicle mediated transport 0.3864747393460242 0.7992494984461136 0.4241457556086865 1.0 0.868427394584091 19 O95249,Q96JB2 2 +Regulation of mitophagy 0.5041137377578379 0.7988778939090184 0.424361218234949 1.0 0.868427394584091 7 P21796,P12235,Q709C8 3 +Nuclear pore complex assembly 0.469135340181502 0.7968120389408434 0.425560202144903 1.0 0.868427394584091 9 Q9BTX1,Q9NQC3 2 +Photoreceptor cell development 0.5373975779070428 0.7920335314970743 0.4283411248001916 1.0 0.868427394584091 5 P54802 1 +Response to interleukin 12 0.7520846696600658 0.7866748150515488 0.4314722507499635 1.0 0.868427394584091 2 Q08722 1 +Negative regulation of receptor mediated endocytosis 0.4441580824571984 0.7864818389782968 0.4315852546264067 1.0 0.868427394584091 11 Q8IZ07,Q9UHD9 2 +Establishment of protein localization to vacuole 0.3987550810649324 0.7858253114810129 0.4319698356518455 1.0 0.868427394584091 17 Q14108,Q709C8,Q92783,P13473,Q9H9H4,P20645 6 +Tor signaling 0.3737356791350124 0.7857057067440829 0.4320399191510282 1.0 0.868427394584091 22 P04062,O75844,Q9H4A6,Q9NWS0 4 +Ventricular cardiac muscle cell development 0.7517639512508001 0.7854491672766474 0.432190263032512 1.0 0.868427394584091 2 P02545 1 +Ventricular cardiac muscle cell differentiation 0.7517639512508001 0.7854491672766474 0.432190263032512 1.0 0.868427394584091 2 P02545 1 +Biomineralization 0.4438384505346765 0.7845782397573549 0.4327008924597213 1.0 0.8686129232679378 11 P20020,Q6P4Q7,O75844 3 +Regulation of acyl coa biosynthetic process 0.7508017960230899 0.7817750862522689 0.4343467650824044 1.0 0.8711088041133672 2 Q15120 1 +Hypoxia inducible factor 1alpha signaling pathway 0.7508017960230899 0.7817750862522689 0.4343467650824044 1.0 0.8711088041133672 2 Q15120 1 +Leukocyte migration 0.3376931561531499 0.7789304479474575 0.4360206868226273 1.0 0.8714268996368422 46 Q5JRA6,Q8NE86,Q08722,P00813,P05556,P35613,P04062,P09601,P46108,Q9H4A6,P78310,Q8N5M9,Q11206,Q8NHP6 14 +Regulation of excretion 0.7268036160014224 0.7785666480829682 0.436235032041651 1.0 0.8714268996368422 3 Q9Y5X3 1 +Cardiac muscle cell membrane repolarization 0.5000250577863437 0.778315189672717 0.4363832229143585 1.0 0.8714268996368422 7 O75844 1 +Alpha ketoglutarate transport 0.748556767158459 0.773219111393023 0.4393927175204841 1.0 0.8740099781283422 2 Q9BQT8 1 +Neuroinflammatory response 0.7482360487491964 0.7719987796542711 0.4401151502796572 1.0 0.8740099781283422 2 P05556 1 +Regulation of dna dependent dna replication 0.3752217769330611 0.7711277831276907 0.440631194094808 1.0 0.8740099781283422 20 O75844 1 +Positive regulation of protein localization to cell periphery 0.3749961034885035 0.769367864235339 0.4416749602384444 1.0 0.8740099781283422 20 P98194,P05556,P23634,O15258,Q12846,O00264 6 +Complement activation 0.7240936798203181 0.7686116417097737 0.4421238923586559 1.0 0.8740099781283422 3 P35232,Q99623 2 +Regulation of humoral immune response 0.7240936798203181 0.7686116417097737 0.4421238923586559 1.0 0.8740099781283422 3 P35232,Q99623 2 +Regulation of complement activation 0.7240936798203181 0.7686116417097737 0.4421238923586559 1.0 0.8740099781283422 3 P35232,Q99623 2 +Receptor mediated endocytosis 0.330454654309645 0.7671990971978881 0.442963149596822 1.0 0.8740099781283422 51 P41440,Q14108,P27824,Q9UHD9,P61978,P50897,O00560,P05556,P11717,Q8IZ07,Q5VW38,P02786,P20645,O75955 14 +Regulation of spontaneous synaptic transmission 0.7469531751122496 0.7671223866642535 0.4430087528875837 1.0 0.8740099781283422 2 P05556 1 +Spontaneous synaptic transmission 0.7469531751122496 0.7671223866642535 0.4430087528875837 1.0 0.8740099781283422 2 P05556 1 +Gamma aminobutyric acid signaling pathway 0.7469531751122495 0.7671223866642519 0.4430087528875845 1.0 0.8740099781283422 2 P04899 1 +Negative regulation of response to external stimulus 0.3374900878477254 0.7659748712130101 0.443691254323828 1.0 0.8740099781283422 45 Q9UMX5,P80303,O43657 3 +Intermediate filament organization 0.5122375325090753 0.7628849993430145 0.4455319830555515 1.0 0.8740099781283422 6 P08670,P07196 2 +External encapsulating structure organization 0.3721011319331259 0.758819704640731 0.447960416665321 1.0 0.8740099781283422 21 P41440,O75718,Q92791,Q04656,P05556,P13674,Q14118,Q96HE7,Q53GQ0 9 +Regulation of rna polymerase ii regulatory region sequence specific dna binding 0.7213691012359418 0.7586304590690321 0.4480736467917208 1.0 0.8740099781283422 3 O75844 1 +Aging 0.3101830255519381 0.7583484101630901 0.4482424335302675 1.0 0.8740099781283422 62 P06493,P20020,P36639,P04062,P53634,P55011,Q12770,Q96MF7,P02545,P00846,O43464,P27824,O60313,P30536,O75844,Q9UGP8,P62993,Q14118,Q96HE7,P02786,P16104 21 +Lipid droplet formation 0.5825156201633301 0.7568421158360462 0.449144457543003 1.0 0.8740099781283422 4 O95674,Q14534 2 +Positive regulation of protein export from nucleus 0.4723620788968232 0.7563233636306466 0.4494553435302393 1.0 0.8740099781283422 8 P50402,Q9C0E2 2 +Peptide transport 0.3556141863020799 0.7513651844550212 0.452432909511741 1.0 0.8741504616918695 28 Q15907,P50416 2 +Positive regulation of smoothened signaling pathway 0.5283082539164983 0.7508201259253329 0.4527609154577972 1.0 0.8741504616918695 5 P16435 1 +Amine catabolic process 0.5282121834972631 0.7503860933426522 0.4530222041081879 1.0 0.8741504616918695 5 P21964 1 +Positive regulation of tor signaling 0.4703351028843252 0.7456198757191251 0.4558970729049147 1.0 0.8741504616918695 8 Q9H4A6 1 +Macrophage proliferation 0.7170764514150145 0.7429628406795744 0.4575041781198992 1.0 0.8741504616918695 3 P04062 1 +Response to l glutamate 0.5261724628650242 0.7411791951829628 0.4585847962193319 1.0 0.8741504616918695 5 O95831 1 +Response to dexamethasone 0.4922127489556611 0.7391499038526264 0.4598159766677807 1.0 0.8741504616918695 7 P04062 1 +Positive regulation of peptidase activity 0.3399093147554872 0.738407684816127 0.4602667461038234 1.0 0.8741504616918695 38 Q9NR28,Q96A26,Q9BXI6,Q96HY6,Q9BXK5,Q92542,Q9P0J0,O95831,P51572,Q9NZJ7 10 +Mrna 3 splice site recognition 0.5779845956354365 0.7381564868506743 0.4604193613101679 1.0 0.8741504616918695 4 Q15637,Q15459,Q12874 3 +Positive regulation of response to wounding 0.4474420561639085 0.737870323961751 0.4605932539233213 1.0 0.8741504616918695 10 Q16625,Q11206,Q04656,P05556 4 +Deoxyribose phosphate catabolic process 0.4917886608498487 0.7370289714353551 0.4611047313178071 1.0 0.8741504616918695 7 P00813 1 +Necrotic cell death 0.3980716590184911 0.736311069928902 0.4615414108804432 1.0 0.8741504616918695 16 P00403,Q13510 2 +Positive regulation of endothelial cell migration 0.3707202092967344 0.7360530766028381 0.4616983974629889 1.0 0.8741504616918695 20 Q8WTV0 1 +Bone mineralization 0.4915602442449879 0.7358868570917363 0.4617995563097536 1.0 0.8741504616918695 7 P20020,O75844 2 +Extracellular vesicle biogenesis 0.4465847541280151 0.7329890828054053 0.4635650879810145 1.0 0.8749872757753214 10 Q92783,Q9Y3E7,O00560,O14964 4 +Cholesterol storage 0.7141482194417426 0.7323172369579806 0.4639749609306738 1.0 0.8753239975523247 3 Q8WTV0,Q9H4M9 2 +Neuron death 0.3129602694621929 0.7315984956142465 0.4644136667297647 1.0 0.8753239975523247 73 Q01105,Q99720,Q9UMX5,Q9NR28,Q96A26,Q07820,P50897,Q92542,P04062,P09601,O76024,P07196 12 +Autophagy of mitochondrion 0.3401233995639656 0.7295182949261669 0.4656846809146344 1.0 0.8755259262837366 35 O43464,Q709C8,P12235,Q9BWH2,P52789,Q13501,Q9H300,P04062,Q99623,O95140,P30536,P21796 12 +Blastoderm segmentation 0.5758141683937679 0.7292353651625266 0.4658577017542615 1.0 0.8755259262837366 4 Q8N2A8 1 +Deoxyribonucleoside triphosphate catabolic process 0.5232544088576919 0.728035896126611 0.466591612884929 1.0 0.8757945574210322 5 P00813 1 +Nucleoside triphosphate catabolic process 0.5232544088576919 0.728035896126611 0.466591612884929 1.0 0.8757945574210322 5 P00813 1 +Water homeostasis 0.4668495601006485 0.7272466533193455 0.4670748713992561 1.0 0.8757945574210322 8 O76024 1 +Positive regulation of granulocyte chemotaxis 0.5223053047453704 0.7237683933247373 0.4692079365700201 1.0 0.8770719730688349 5 Q8NHP6,Q8NE86 2 +Positive regulation of neutrophil migration 0.5223053047453704 0.7237683933247373 0.4692079365700201 1.0 0.8770719730688349 5 Q8NHP6,Q8NE86 2 +Regulation of erbb signaling pathway 0.433427259787998 0.7227376206831481 0.469841097806476 1.0 0.8772529211848267 11 Q9NQC3 1 +Regulation of endothelial cell migration 0.3489398624438374 0.7176081671629067 0.4729989204344407 1.0 0.87806955268273 29 P09601,Q8WTV0,P42785 3 +Retina development in camera type eye 0.3952881614362394 0.7170617755030638 0.4733359800970538 1.0 0.87806955268273 16 P20020,Q8NBN7,Q8NF37,P54802 4 +Cellular hyperosmotic salinity response 0.5722476340064007 0.7146192703839896 0.4748443339608967 1.0 0.8785093804713998 4 O95202 1 +Hyperosmotic salinity response 0.5722476340064007 0.7146192703839896 0.4748443339608967 1.0 0.8785093804713998 4 O95202 1 +Cellular response to salt stress 0.5722476340064007 0.7146192703839896 0.4748443339608967 1.0 0.8785093804713998 4 O95202 1 +Placenta development 0.3663279558880131 0.713236543510604 0.4756993967499967 1.0 0.8796275976988766 21 Q15363,P00813 2 +Endocytosis 0.3529487706785698 0.7123439960669428 0.4762517861967956 1.0 0.8796275976988766 116 P41440,Q9BZG1,O15118,Q9NX40,P18031,O15260,Q5JRA6,Q14108,Q96RU3,Q9UHD9,P61978,P50897,Q9H4M9,Q8IZ07,Q96D71,Q14185,O60749,P27824,Q8N6T3,Q9UBG0,P11717,P05556,Q9H223,O00560,O15126,P20645,P61020,Q05086,P27361,Q8WTV0,Q9Y5X3,Q08380,Q5VW38,P57105,Q4KMQ2,P02786,P51790,O75955 38 +Exocytosis 0.3083662483798268 0.7121679565437368 0.4763607769332898 1.0 0.8796275976988766 70 P16615,Q5JRA6,Q9BRK5,Q12846,P61026,Q9Y3E7,O00560,O95721,Q9P253,P09601,O43760,P49755,P11279,Q4J6C6,Q15907,Q8N5M9 16 +Negative regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway 0.4634598550540707 0.7094205490531466 0.4780635395371491 1.0 0.8803910131470062 8 O76024,O60313 2 +Positive regulation of sequestering of triglyceride 0.731558691468888 0.7092541486369675 0.4781667763950006 1.0 0.8803910131470062 2 Q9BXB4 1 +Positive regulation of smooth muscle cell proliferation 0.4629708322352942 0.7068524357071723 0.4796581849297476 1.0 0.8808885251948859 8 P35232,P09601,O95140 3 +Long term synaptic potentiation 0.441895987351274 0.706339433176635 0.479977076299966 1.0 0.880888637833791 10 Q12846,Q14168,Q9BPZ3,Q92542 4 +Plasma membrane raft assembly 0.706192943375128 0.7035766204665767 0.4816964753430632 1.0 0.880888637833791 3 P41440 1 +Plasma membrane raft organization 0.706192943375128 0.7035766204665767 0.4816964753430632 1.0 0.880888637833791 3 P41440 1 +Copii coated vesicle budding 0.3632935410100723 0.7020113140982118 0.4826721076315396 1.0 0.880888637833791 22 Q9UBV8,Q15363,Q9NR31,P49755,Q12770 5 +Negative regulation of mrna catabolic process 0.3613570357907323 0.7007589790100013 0.4834534420184342 1.0 0.880888637833791 23 Q99729,P07910,Q92804,P98175,O60506,Q14011,P35637,Q14103 8 +Calcium ion transport 0.316834793970345 0.6997272445543196 0.4840976586277989 1.0 0.880888637833791 56 P20020,Q96GC9,Q9UM00,P21796,O95202,P05026,P16615,P98194,P08195,P23634,P04899,Q9Y4W6,P30536,O75844,Q9BPX6,Q8NE86,O76024,Q96HE7,Q4KMQ2,Q9UJZ1,Q8IYU8 21 +Synaptic signaling 0.3223472232295661 0.6977333220935475 0.485343985025735 1.0 0.880888637833791 85 P41440,Q9UQB8,P16615,Q9BPZ3,P50897,Q92542,Q4J6C6,Q12846,Q9NR77,O00560,O95721,Q14168,Q96A49,Q13641,Q9BVA1,Q8NCG7,Q9P253,Q14118,P57105,P51790,P52292 21 +Regulation of response to endoplasmic reticulum stress 0.3609478239215172 0.6974379076924688 0.485528785166414 1.0 0.880888637833791 23 Q9UHD9,P57088,Q96HY6,O60313,P51572,P46379,O76024,P18031 8 +Cellular glucose homeostasis 0.3370715999112897 0.6965860560289814 0.4860618847209212 1.0 0.880888637833791 33 P52789,Q12846,O00459,Q15043,Q15907,Q8N5M9,Q9NWS0 7 +Membrane repolarization 0.4504738453973061 0.6945565298972803 0.4873332625028834 1.0 0.880888637833791 9 O75844 1 +Post translational protein modification 0.4397868371513307 0.6943792507262194 0.4874444026008158 1.0 0.880888637833791 10 Q32P28,O60725 2 +Response to mineralocorticoid 0.497644342840091 0.6936103089418098 0.4879266269791884 1.0 0.880888637833791 6 P07196,O95831 2 +Positive regulation of organic acid transport 0.496975966939056 0.6904572303461575 0.4899066973202122 1.0 0.880888637833791 6 Q15041,P55011,P05556 3 +Protein targeting to vacuole 0.3964175212979368 0.6856044155146475 0.4929625963726975 1.0 0.880888637833791 15 Q14108,Q709C8,P13473,Q9H9H4,P20645 5 +Negative regulation of mrna metabolic process 0.3297828396303743 0.685014286414221 0.493334905878668 1.0 0.880888637833791 45 Q99729,Q16629,Q13242,P38159,P07910,P26368,P98175,Q92804,P50750,O60506,P22626,Q14011,P35637,Q14103 14 +Protein localization to presynapse 0.7006737247353236 0.683800438583586 0.494101189615 1.0 0.880888637833791 3 Q14168,P04792 2 +Axo dendritic protein transport 0.7006737247353236 0.683800438583586 0.494101189615 1.0 0.880888637833791 3 Q14168,P04792 2 +Cytosolic transport 0.300940270834734 0.6831608651629886 0.4945051986175846 1.0 0.880888637833791 65 Q8NBN3,Q9BXI6,P11279,Q13190,O15260,Q9UNK0,Q709C8,Q9Y3E7,O43752,P61106,Q4J6C6,P49257,O75503,O60749,O60499,O95249,P53367,P27361,Q9BVK6,Q9Y5X3,Q96RL7 21 +Adenylate cyclase activating adrenergic receptor signaling pathway 0.7004395331833126 0.6829643842712968 0.4946293481263466 1.0 0.880888637833791 3 P23634 1 +Meiosis i cell cycle process 0.3777379639042892 0.6820248297674137 0.4952232505371476 1.0 0.880888637833791 18 Q15645,Q92791,P46379,Q9BTX1,Q9NY64 5 +Humoral immune response mediated by circulating immunoglobulin 0.7238614496472245 0.6808023892358303 0.4959965380592979 1.0 0.880888637833791 2 Q9UQ84 1 +Secretion 0.3747801142472352 0.6797392730344782 0.49666956415704 1.0 0.880888637833791 144 Q9H7Z7,Q96PC5,P61026,Q04656,Q9UBV2,P11279,Q15907,P50416,P16615,Q5JRA6,P04035,P50897,Q9Y3E7,Q13505,Q4J6C6,Q12846,Q8N5M9,P27824,P52789,Q9BRK5,P00813,O00560,O95721,O43760,P49755,Q9H4A6,P35670,P20645,P00403,Q8NE86,Q92783,Q32P28,P55327,Q9Y5X3,Q16850,Q9P253,P09601,Q96KC8 38 +Eosinophil mediated immunity 0.723220012828734 0.6784469307382635 0.4974883613894683 1.0 0.880888637833791 2 Q12846 1 +Regulation of histamine secretion by mast cell 0.723220012828734 0.6784469307382635 0.4974883613894683 1.0 0.880888637833791 2 Q9UNH7 1 +Eosinophil activation 0.723220012828734 0.6784469307382635 0.4974883613894683 1.0 0.880888637833791 2 Q12846 1 +Er associated misfolded protein catabolic process 0.4798437928542552 0.6775430003675642 0.4980614970113808 1.0 0.880888637833791 7 P46379,Q9BUN8,Q9Y679 3 +Protein hexamerization 0.4933381425299397 0.6733295006641365 0.5007376886851977 1.0 0.8825577711645488 6 O95202,Q8TDW0 2 +Protein localization to endoplasmic reticulum exit site 0.5600961115670042 0.6652578988260999 0.5058855537388189 1.0 0.8861091397483408 4 P51572 1 +Protein o linked glycosylation via serine 0.6954218815139909 0.6651139695706458 0.5059776002845193 1.0 0.8861091397483408 3 Q10472 1 +Positive regulation of phospholipase activity 0.4913108750265237 0.6638103165301786 0.5068117219485524 1.0 0.8863016558363115 6 Q99623 1 +Regulation of cysteine type endopeptidase activity 0.3267642555543357 0.6631116702082862 0.5072590369412215 1.0 0.8863016558363115 46 O14737,Q9NR28,Q96A26,Q9BXI6,P16435,Q9BXK5,O95831,Q9P0J0,Q15392,P51572,Q15041,Q9NZJ7,Q9NWS0 13 +Regulation of insulin secretion 0.3612349653560009 0.662416641015235 0.5077042417061151 1.0 0.8863016558363115 20 Q12846,Q8N5M9,Q8NE86,P50416 4 +Cognition 0.332883050889184 0.6594520812847956 0.5096055074755208 1.0 0.8867979697540457 35 Q9H0U3,Q9BPZ3,Q05086,P17900,P04035,P50897,Q92542,P05556,Q13641,Q9NRG9,O00264,Q9UQN3,Q11206 13 +Olefinic compound metabolic process 0.3869187193014357 0.6593838731788243 0.5096492953099729 1.0 0.8867979697540457 16 P07099,Q8NBN7,Q8NCG7,Q9H7Z7 4 +Peripheral nervous system axon regeneration 0.6934663381956465 0.6581900648925749 0.5104160080408828 1.0 0.8876562347177634 3 P07196 1 +Phagosome lysosome fusion 0.692974013474498 0.6564498925433454 0.5115346975936357 1.0 0.8877712390057876 3 Q9BZG1,Q9NVJ2 2 +Monocyte chemotaxis 0.4753232810126647 0.6551733176655146 0.5123561714162541 1.0 0.8877712390057876 7 P17931,Q8NHP6,Q4KMQ2 3 +Intrinsic apoptotic signaling pathway in response to oxidative stress 0.3861220068347219 0.6539113476650484 0.513168922626452 1.0 0.8877712390057876 16 O43464,Q9NR28,P07237,Q15233,P23246,Q15118,Q07820,O75915 8 +Regulation of epithelial to mesenchymal transition 0.4749163232652739 0.6531637747973381 0.5136507012611504 1.0 0.8877712390057876 7 Q14118 1 +Protein localization to plasma membrane 0.308672509214863 0.6510800133181377 0.51499483766109 1.0 0.8877712390057876 75 P41440,Q9BZG1,O15400,Q15363,P61026,P35613,P31751,P05026,P98194,Q13501,Q9H4M9,P23634,Q4J6C6,Q12846,Q15904,Q9Y2J2,Q9H223,P05556,O15258,Q9H4A6,Q13641,O00264,O75955,O75915 24 +Vesicle organization 0.330261015035634 0.6506759308652631 0.515255703572147 1.0 0.8879851413831639 97 Q9BZG1,Q9UBV8,O15400,Q15363,P82094,Q13190,P31751,Q12770,Q9UNK0,Q14108,Q5JRA6,Q15075,Q9BSR8,P62820,O95292,Q13501,Q9Y3E7,O14964,Q9NR31,O43752,P61106,Q6IAA8,Q12846,Q9UQN3,P51149,Q9BXS5,Q86Y82,Q9HD42,O00560,O95721,O60499,O95249,P49755,Q9H9H4,Q9H4A6,Q9BTU6,Q92734,P61020,P51809,Q92783,Q9BVK6,Q9HCU5,P78537,Q9P253,P51790,Q9NVJ2,O75396,O60493 48 +Positive regulation of chemotaxis 0.3733394292062782 0.6500046219360645 0.5156892361010201 1.0 0.8880250718217036 18 P27361,Q8NE86,P04792,Q4KMQ2,Q12846,Q13641,Q8NHP6 7 +Negative regulation of mitochondrion organization 0.3794119566077859 0.6484442570334455 0.5166976534373469 1.0 0.8882529263195348 17 Q96E52,Q9H300,Q9H3K2,O60313,P30536,P02545,P02786 7 +Regulation of b cell mediated immunity 0.4312329870791702 0.6460733529500315 0.5182318516125717 1.0 0.8898072416473989 10 Q96FZ2,O96028 2 +Regulation of isotype switching 0.4312329870791702 0.6460733529500315 0.5182318516125717 1.0 0.8898072416473989 10 Q96FZ2,O96028 2 +Lymphocyte activation involved in immune response 0.3459058009752048 0.6436409520326326 0.5198082881300947 1.0 0.8910999225087337 27 Q96FZ2,Q9UQ84,O96028,Q04656,P00813,P11279 6 +Export from cell 0.3612316050432564 0.6392705245327295 0.5226469599600194 1.0 0.8921967036709035 132 P20020,Q96PC5,P61026,Q9UBV2,P11279,Q15907,P50416,P16615,Q5JRA6,P04035,P50897,Q9Y3E7,Q4J6C6,Q12846,Q8N5M9,P08183,P27824,Q9BRK5,P05023,O00560,O95721,O43760,P49755,Q9H4A6,P35670,P20645,Q8NE86,Q92783,Q32P28,Q16836,Q16850,Q9P253,P09601,Q96KC8 34 +Response to arsenic containing substance 0.4124246317370803 0.6386442843176828 0.5230543656144282 1.0 0.8924228492953661 12 P09601 1 +Second messenger mediated signaling 0.3449381376971382 0.6352983553950816 0.5252338460123833 1.0 0.8933260923727151 27 P16615,P00813,P23634,P51572,O75844 5 +Negative regulation of cellular amine metabolic process 0.7103912764592865 0.6318692907620403 0.52747229149933 1.0 0.8949816724771938 2 P23634 1 +Peptidyl proline hydroxylation to 4 hydroxy l proline 0.5517269530071433 0.6316937562987062 0.5275870087138357 1.0 0.8949816724771938 4 P13674,Q96HE7 2 +Positive regulation of telomere capping 0.6857169542631739 0.6309420925277852 0.5280783881359552 1.0 0.8953207197298434 3 Q14103 1 +Regulation of epithelial cell migration 0.327541402382604 0.6307551857781925 0.5282006094524492 1.0 0.8953207197298434 41 P09601,Q8WTV0,P42785,Q9NQC3 4 +Negative regulation of endocytosis 0.396217885717073 0.6300946662956031 0.5286326491441555 1.0 0.8957409926134331 14 Q8IZ07,Q9UHD9 2 +Leukocyte proliferation 0.3299557568699151 0.6288139348527244 0.5294708760891949 1.0 0.8966247026711947 33 P00813,P30825,Q92542 3 +Regulation of histone h4 acetylation 0.4477770227768234 0.6275816919805471 0.5302780051836615 1.0 0.8966247026711947 8 O75844 1 +Positive regulation of rna splicing 0.3536787322277293 0.6253738632296835 0.5317257121294403 1.0 0.8974772386288203 22 P26368,P38159,Q14011,Q13595,P98179 5 +Outer ear morphogenesis 0.6833725741736145 0.6227607633087572 0.5334417459222252 1.0 0.8980121179669627 3 O75569 1 +Long chain fatty acyl coa metabolic process 0.4371768779490488 0.6225444943207088 0.5335838960086441 1.0 0.8980121179669627 9 Q9NZ01,Q8WVX9,Q53GQ0 3 +Neurotransmitter metabolic process 0.5490646374973649 0.6210974595004115 0.5345355007113479 1.0 0.8980480195286364 4 P21964 1 +Regulation of biomineralization 0.4683806468493128 0.6209948200653994 0.5346030313708061 1.0 0.8980480195286364 7 P20020,O75844 2 +Positive regulation of macroautophagy 0.3530515518354412 0.6203937467903707 0.5349985883281336 1.0 0.8980480195286364 22 P12235,Q9Y371,P09601,P05141,O15269,P21796,Q8TBX8 7 +Regulation of epithelial cell apoptotic process 0.4263887897182868 0.6188771143655522 0.5359973160600497 1.0 0.8986814503775421 10 P09601 1 +Positive regulation of nucleotide metabolic process 0.4984843722751024 0.6180300046664289 0.536555560218944 1.0 0.8993851528379512 5 P00403 1 +Positive regulation of endothelial cell development 0.7059012187299524 0.6158180543575175 0.5380146101781886 1.0 0.900849061588084 2 P35611 1 +Regulation of peptide transport 0.3537679182906613 0.6146086584508839 0.5388131949579023 1.0 0.9011814235201628 21 Q12846,Q8N5M9,Q8NE86,P50416 4 +Stem cell proliferation 0.4080697267535673 0.6123887073696985 0.540280611444492 1.0 0.902123828806056 12 P08183,P04062 2 +Ribonucleoprotein complex localization 0.4664177809691625 0.6113738093298847 0.5409521374323321 1.0 0.902123828806056 7 Q08J23,Q8WWY3,Q9ULX6 3 +Positive regulation of nervous system process 0.546606184246764 0.6113489567864085 0.5409685868056031 1.0 0.902123828806056 4 P04062,Q14118 2 +Regulation of long chain fatty acid import across plasma membrane 0.7042976266837689 0.6101185840195555 0.5417832568710355 1.0 0.9021903713970776 2 P31751 1 +Positive regulation of leukocyte mediated immunity 0.3516758881816182 0.6094797236302764 0.5422065085890244 1.0 0.9021903713970776 22 P04439,P01889,O15400,Q96FZ2,P02786,O96028,P11279,Q12846 8 +Central nervous system maturation 0.7039769082745468 0.6089808157212159 0.5425371549498137 1.0 0.9021903713970776 2 O75787 1 +Action potential 0.3527774680569366 0.6068720914836203 0.5439358006087835 1.0 0.9023951569438092 21 P04062,P16615,P05023 3 +Lipid droplet organization 0.4342030356557401 0.6065632266343056 0.5441408107170003 1.0 0.9023951569438092 9 Q96CS3,O95674,Q14534 3 +Respiratory gaseous exchange by respiratory system 0.4132615346130173 0.6041960686514368 0.5457132943681025 1.0 0.9032800756445916 11 Q7KZN9,O60476,P10253 3 +Regulation of protein folding 0.5443346339509089 0.6023734911221238 0.5469255515004954 1.0 0.9032800756445916 4 O14737 1 +Acute inflammatory response 0.5441510818440429 0.6016495928275764 0.5474074100428921 1.0 0.9033474595827288 4 P42785,Q4KMQ2 2 +Plasma membrane to endosome transport 0.5439849018276014 0.6009943844290917 0.5478437265525604 1.0 0.9034711951440604 4 Q8N668,P61020 2 +Myelin maintenance 0.5439694241876745 0.6009333683548129 0.5478843671376119 1.0 0.9034711951440604 4 Q9Y2J2,P31751 2 +Cytoplasm organization 0.7004490057729552 0.5965127782889479 0.5508327199684426 1.0 0.9050328046590668 2 Q8N2A8 1 +Insulin receptor signaling pathway 0.3295704640348588 0.5955995576957935 0.5514427722202466 1.0 0.9050328046590668 31 P04899,O00459,Q15043,Q8TBX8,Q9Y5X3,P49840,P62993,Q9UQB8,P18031,P25054,P43490,Q9NY64,P31751 13 +Positive regulation of exosomal secretion 0.4415691687279552 0.595528823043824 0.5514900384402011 1.0 0.9050328046590668 8 Q92783,O14964,O00560 3 +Phosphatidylinositol phosphate biosynthetic process 0.4222031115990545 0.5954838869490425 0.5515200666150442 1.0 0.9050328046590668 10 Q96PE3,O00459,Q8TBX8,Q9NX62 4 +Cellular defense response 0.5422076712109088 0.5939978036435949 0.5525135819878484 1.0 0.9055587412938934 4 Q08380 1 +Response to salt stress 0.4760281736989564 0.5927117663957691 0.5533740655568209 1.0 0.9066623089485396 6 O95202 1 +Regulation of receptor binding 0.5408085599623416 0.5885036232517836 0.5561943025858065 1.0 0.9071054237081988 4 P16615 1 +Positive regulation of reactive oxygen species biosynthetic process 0.5404319944911371 0.5870269916379562 0.5571855789761053 1.0 0.9075171202077544 4 P00403 1 +Regulation of potassium ion import 0.6721006288868461 0.5838502383632358 0.5593210748463915 1.0 0.9095972990738412 3 P05026 1 +Maintenance of protein localization in organelle 0.3811071482389509 0.5835554212225358 0.5595194598192468 1.0 0.9096363430009388 15 P52789,O94901,P30536,Q9UH99,P24390 5 +Neutrophil differentiation 0.5394272654010004 0.5830915469817954 0.5598316738599487 1.0 0.9096363430009388 4 Q8N5M9,Q14739 2 +Negative regulation of fat cell differentiation 0.4724977063233938 0.5764723051475747 0.5642959841468089 1.0 0.9147089960252394 6 Q8N4Q0,Q8IXJ6 2 +Regulation of organic acid transport 0.4283563893634272 0.5752964920364573 0.5650907935848108 1.0 0.9155401627034172 9 P05556,P55011,Q15041,O75915,P31751 5 +Icosanoid biosynthetic process 0.4184944549755111 0.5748462526887267 0.565395282421469 1.0 0.915804933503038 10 Q8NCG7,P09960,Q9H7Z7,Q99735 4 +Negative regulation of collateral sprouting 0.6937139191789758 0.5729579854279552 0.5666731418312521 1.0 0.9164865609329144 2 Q15375 1 +Endosome to lysosome transport via multivesicular body sorting pathway 0.536814757139686 0.5728890341322622 0.5667198298871232 1.0 0.9164865609329144 4 Q9UQN3 1 +Regulation of proton transport 0.4176227994796708 0.5700086791782223 0.5686718114665017 1.0 0.9164865609329144 10 Q99623,Q8TAD4 2 +Regulation of receptor internalization 0.3939805236280937 0.5689329224036699 0.5694016620167612 1.0 0.9164865609329144 13 Q8IZ07,P41440,O00560,Q9UHD9 4 +Axonal transport of mitochondrion 0.4871592350463902 0.5688542274139733 0.5694550704247994 1.0 0.9164865609329144 5 P07196 1 +Regulation of protein tyrosine phosphatase activity 0.6924310455420111 0.5685092905923218 0.5696891990037409 1.0 0.9164865609329144 2 P04899 1 +Cellular response to mineralocorticoid stimulus 0.6668342957993709 0.5659253349379408 0.5714445382533666 1.0 0.9170802895296104 3 O95831 1 +Isotype switching to iga isotypes 0.6667023544290228 0.565478422356896 0.571748396816806 1.0 0.9170802895296104 3 O96028 1 +Endoplasmic reticulum plasma membrane tethering 0.6666666666666641 0.5653575590728113 0.5718305856889918 1.0 0.9170802895296104 3 O95292,A0FGR8 2 +Endoplasmic reticulum localization 0.6666666666666641 0.5653575590728113 0.5718305856889918 1.0 0.9170802895296104 3 O95292,A0FGR8 2 +Positive regulation of cell cell adhesion mediated by cadherin 0.5347060077399732 0.5646865752787258 0.5722869669921249 1.0 0.9170802895296104 4 P41440 1 +Positive regulation of calcium ion import 0.6895445798588806 0.5585452820141072 0.5764720925077707 1.0 0.9195723437206004 2 P17931 1 +Carbohydrate homeostasis 0.3176858495854473 0.5584137121832505 0.5765619115241267 1.0 0.9195723437206004 45 P52789,O00459,Q15043,P42785,O76024,Q15907,Q8N5M9,Q9NWS0 8 +Cellular response to carbohydrate stimulus 0.3379601629057742 0.5566392821997849 0.5777739091086576 1.0 0.9195723437206004 26 Q15907,Q8N5M9,Q9NWS0 3 +Regulation of cell cell adhesion mediated by cadherin 0.4841841066387727 0.556073562513361 0.5781605673113699 1.0 0.9195723437206004 5 P41440 1 +Semaphorin plexin signaling pathway involved in neuron projection guidance 0.6634310913277335 0.5544327216058685 0.5792827374146075 1.0 0.9195723437206004 3 P42892 1 +Gonadotropin secretion 0.6876202694034605 0.5519381596902454 0.5809907227857225 1.0 0.9195723437206004 2 P82094 1 +Lymphocyte apoptotic process 0.3836244415956867 0.549538333452658 0.582636065181328 1.0 0.9195723437206004 14 P24390 1 +Steroid hormone biosynthetic process 0.4662831355040714 0.5480768689901518 0.5836391225286017 1.0 0.9195723437206004 6 Q53GQ0 1 +Bone development 0.3423461391012503 0.5475163939919435 0.5840240106501766 1.0 0.9195723437206004 23 Q7RTS9,Q32P28,P16435,Q9NX62,O75844,Q15904 6 +Purine containing compound catabolic process 0.3900344524960249 0.5446640042723081 0.585984625842654 1.0 0.9195723437206004 13 P00813 1 +Nucleoside triphosphate metabolic process 0.31550464496748 0.5443073888041934 0.5862299632382113 1.0 0.9195723437206004 46 P24539,Q9H773,O75746,P00813,O60313,Q9UJS0,P00403,P56385,P00846,O75964 10 +Negative regulation of rna splicing 0.3524164168907521 0.5439189110810881 0.5864972748091284 1.0 0.9195723437206004 19 P26368,Q16629,Q13242,P38159,P98175,P22626 6 +Negative regulation of mrna processing 0.3418699744656794 0.5437130086800078 0.586638979184277 1.0 0.9195723437206004 23 P26368,Q16629,Q13242,P38159,P98175,P50750,P22626 7 +Microtubule anchoring at microtubule organizing center 0.4809127717314936 0.5420916029646022 0.5877554030633627 1.0 0.9195723437206004 5 Q8TD16 1 +Negative regulation of endoplasmic reticulum unfolded protein response 0.4805971022513314 0.5407464533976332 0.5886823550780043 1.0 0.9195723437206004 5 Q96HY6,O76024 2 +Negative regulation of axonogenesis 0.4645874464719809 0.5403734455171747 0.5889395169298599 1.0 0.9195723437206004 6 Q9NQC3 1 +Fatty acid alpha oxidation 0.6576064542318192 0.5349346063041385 0.5926950772861774 1.0 0.9195723437206004 3 A1L0T0 1 +Caveolin mediated endocytosis 0.5269576379974409 0.5348096085230839 0.5927815181518947 1.0 0.9195723437206004 4 P28482,Q96PU5,P27361 3 +Positive regulation of smooth muscle cell apoptotic process 0.6569188263126478 0.5326474180199003 0.5942776713429949 1.0 0.9195723437206004 3 O95140 1 +Positive regulation of protein localization to cell surface 0.5261100517611188 0.5315673011432016 0.5950257170074713 1.0 0.9195723437206004 4 Q12846 1 +Long chain fatty acid import across plasma membrane 0.6564003849855614 0.5309250616297695 0.5954707100691883 1.0 0.9195723437206004 3 P33121,P31751 2 +Regulation of dendritic cell differentiation 0.6563866250933619 0.5308793732382524 0.5955023722937389 1.0 0.9195723437206004 3 P01889 1 +Anterior posterior axis specification 0.4190334964149512 0.5259085531420193 0.5989517458990856 1.0 0.9211034136450564 9 Q15363,Q8N2A8 2 +Response to axon injury 0.3869195328439259 0.5255926796998982 0.5991712439653534 1.0 0.9211034136450564 13 P07196,P30536,P00374 3 +Myotube differentiation 0.371344628236493 0.5193294737979558 0.6035310032661534 1.0 0.923806471421923 15 P41440,O75955,Q8IV08,P05556 4 +Synaptic vesicle exocytosis 0.3609397006109135 0.5192484132405385 0.6035875221404945 1.0 0.923806471421923 17 O95721,P16615,Q9P253,Q4J6C6 4 +Leukocyte apoptotic process 0.3550329935517221 0.5181356671966612 0.6043636164502386 1.0 0.9244883595652564 18 P24390 1 +Cell killing 0.3486950284117683 0.516502911652654 0.6055032058794194 1.0 0.9253733438793356 19 P51809,P04439,P01889,O15400,P07437,P53634,P46108,P11279,Q9NVJ2,Q9NUQ9,P68371 11 +Threonine metabolic process 0.6518295164704513 0.5158184211249076 0.6059812354160494 1.0 0.9253733438793356 3 O43175 1 +Positive regulation of interferon gamma production 0.474563137279066 0.5151764565555516 0.6064297193881885 1.0 0.9253733438793356 5 P04439,Q5ZPR3 2 +Localization within membrane 0.3934024485767806 0.5151295202703376 0.6064625154484702 1.0 0.9253733438793356 185 Q8N668,P41440,Q9BZG1,Q8N4V1,O15400,Q15363,Q15006,P61026,O15118,Q9NS69,Q9P0J0,P35613,Q9NPA0,Q9HD20,Q15041,Q15907,P49354,P31751,P05026,P98194,Q9H6R6,Q53H12,Q9HD45,P43307,Q13501,Q9H4M9,Q99442,P23634,Q7Z3B4,Q5J8M3,O43752,P40855,Q9UNL2,Q4J6C6,Q12846,Q5BJH7,Q15629,O60826,Q15904,Q9Y512,Q99805,Q15070,Q9Y2J2,P05556,Q9H223,O43765,O15258,Q9GZY8,O00560,Q9Y5J9,Q9H9H4,Q9H4A6,Q9NZJ7,Q9BTX1,Q14168,Q9UGP8,Q13641,O14737,Q92544,O43681,O60725,Q9Y371,Q9Y276,O00264,P46379,Q14118,P57105,O75955,O75915,Q96A33 70 +Glycerol 3 phosphate metabolic process 0.675753688261703 0.5118474417342714 0.6087577844038139 1.0 0.927067211196445 2 P43304 1 +Response to platelet derived growth factor 0.4581632263105011 0.5113730973309506 0.6090898291553546 1.0 0.927067211196445 6 Q04656 1 +Positive regulation of atp biosynthetic process 0.5189949571218664 0.5045615749895153 0.6138668038919994 1.0 0.9280911250272148 4 P00403 1 +Positive regulation of nucleotide biosynthetic process 0.5189949571218664 0.5045615749895153 0.6138668038919994 1.0 0.9280911250272148 4 P00403 1 +Regulation of action potential 0.4047128136463466 0.4990053146496852 0.617775639977618 1.0 0.9320472820670918 10 P16615,P04062 2 +Nuclear membrane reassembly 0.3824009960590435 0.498073777068906 0.6184320425737984 1.0 0.9321258136757252 13 Q8IXJ6,Q86XL3,Q9Y3E7,Q9H6H4,Q9UQN3 5 +Protein localization to microtubule end 0.6703014753046788 0.4938208777722779 0.6214326872003304 1.0 0.9347407333884488 2 Q15555 1 +Positive regulation of vacuole organization 0.4685138189847107 0.4898262366089869 0.6242568633434971 1.0 0.9357796323956972 5 Q9Y371 1 +Intermediate filament bundle assembly 0.6428422666013021 0.4865417554339727 0.626583107925434 1.0 0.9359786798751208 3 P07196 1 +Plus end directed organelle transport along microtubule 0.6680564464400218 0.4864732905540461 0.6266316380521371 1.0 0.9359786798751208 2 P33176 1 +Torc2 signaling 0.6415360577712874 0.4823353617286204 0.6295677308133549 1.0 0.9372892062968564 3 Q9NWS0 1 +Chromosome organization involved in meiotic cell cycle 0.360697840168467 0.4816055329520005 0.6300861949347323 1.0 0.9372892062968564 16 Q15645,P46379,Q92791,Q9BTX1 4 +Regulation of system process 0.2916242586163463 0.4807124922069433 0.6307208513861666 1.0 0.9372892062968564 60 P16615,P20020,O75746,P05023,Q9Y5X3,Q6PI78,P10253,P00813,P04062,P23634,Q14118,P78310,O75844,P42892 14 +Terpenoid biosynthetic process 0.466130339495984 0.4799207490751885 0.6312837466676073 1.0 0.9372892062968564 5 O95749,P14324 2 +Mitochondrial fission 0.3649041229127932 0.4774223668195207 0.6330613902219233 1.0 0.9372892062968564 15 Q9UDX5,Q9GZY8,O60313 3 +Leukocyte degranulation 0.3911307119468895 0.476992443106602 0.6333675028099055 1.0 0.9374878769361392 11 P51809,P09601,P11279,Q12846,Q9UNH7 5 +Maintenance of blood brain barrier 0.4377640701334694 0.4735474933267013 0.6358226257069797 1.0 0.9396996662884348 7 Q16625,P55011,P05556 3 +Cardiac ventricle development 0.3714394625861364 0.4727936317807837 0.6363604178656717 1.0 0.9396996662884348 14 O75844 1 +Leukocyte mediated immunity 0.3049447005219508 0.4726530174906634 0.636460750959281 1.0 0.9396996662884348 50 O15400,P53634,P11279,Q96FZ2,Q9UQ84,O96028,Q12846,Q8N5M9,Q9UNH7,P04439,P07437,P46108,Q07021,P51809,P01889,Q99584,P09601,P02786,Q9NUQ9,P68371 20 +Positive regulation of g protein coupled receptor signaling pathway 0.5103968764127056 0.4724596203765569 0.6365987572915182 1.0 0.9396996662884348 4 P35232,Q15043 2 +Maintenance of protein location in cell 0.3340435320018341 0.4710278844547643 0.6376208223383437 1.0 0.9402165105434616 22 P52789,O94901,O15258,P30536,Q9UH99,Q9H4A6,P24390 7 +Cell adhesion mediated by integrin 0.4486641797255619 0.4690704520205401 0.6390192787211619 1.0 0.9409192917799464 6 P00813,P05556 2 +Very long chain fatty acid metabolic process 0.4075638120692206 0.4660716997700008 0.641164179479369 1.0 0.9421415510681054 9 Q15067,Q9P035 2 +Regulation of wound healing 0.363114806421932 0.4658543232396335 0.6413197779673943 1.0 0.9421415510681054 15 Q16625,P46108,Q11206,P05556 4 +Respiratory system development 0.3228914230550635 0.4655141156365209 0.6415633307721007 1.0 0.9421415510681054 28 O60476,P38571,P09960,P00813,Q04656,Q14118 6 +Body morphogenesis 0.4072005585762546 0.464195286305435 0.6425078380530753 1.0 0.943061470639965 9 O95470,Q14118 2 +Vesicle fusion to plasma membrane 0.5080733379303807 0.4638900838247027 0.6427264976711025 1.0 0.9431691733455688 4 O95721 1 +Pigmentation 0.3350347017228559 0.4622885861355983 0.6438743836189871 1.0 0.9432478627140216 20 Q15907,Q8TAA9,Q13561,Q04656 4 +Cellular response to gamma radiation 0.4064184407926933 0.4601593498547258 0.6454018464616151 1.0 0.9432478627140216 9 P12956,Q9BVC6,O75844 3 +Hormone transport 0.3117851073392798 0.458445746366232 0.6466322320317821 1.0 0.9432478627140216 32 Q15907,P50416 2 +Forebrain neuron development 0.4460628343880954 0.4576157882341738 0.6472284985760357 1.0 0.9432478627140216 6 O14949 1 +Forebrain neuron differentiation 0.4460628343880954 0.4576157882341738 0.6472284985760357 1.0 0.9432478627140216 6 O14949 1 +Hepatocyte growth factor receptor signaling pathway 0.4460349411845579 0.457493282679992 0.6473165293924426 1.0 0.9432478627140216 6 Q8IXJ6 1 +Coenzyme a metabolic process 0.3970106491951121 0.4572999691635079 0.6474554518777742 1.0 0.9432478627140216 10 Q8WVC6 1 +Negative regulation of nitric oxide synthase activity 0.6336377594808882 0.4571748215421566 0.6475453942935012 1.0 0.9432478627140216 3 P06280 1 +Negative regulation of monooxygenase activity 0.6336377594808882 0.4571748215421566 0.6475453942935012 1.0 0.9432478627140216 3 P06280 1 +Regulation of reactive oxygen species metabolic process 0.3116311434768267 0.4570187621133396 0.6476575599435215 1.0 0.9432478627140216 32 O75027,P52789,Q9H300,P42785,P30536,P51790,P00374,P00403 8 +Regulation of post translational protein modification 0.632852007544189 0.4546980929300996 0.6493264530593075 1.0 0.9448472013985458 3 Q32P28 1 +Hepaticobiliary system development 0.311490723423631 0.4544169983380147 0.649528720058524 1.0 0.9448472013985458 35 P09601,O75844,P00813 3 +Immunoglobulin production 0.3291146128156118 0.454209481272099 0.6496780595182217 1.0 0.9448472013985458 24 P35232,Q96FZ2,Q9UQ84,O96028,Q99623,Q12846 6 +Insulin metabolic process 0.6325679846349015 0.4538040346887655 0.6499698793823621 1.0 0.9449806721743932 3 Q8TAD4 1 +Positive regulation of amyloid beta clearance 0.6558691468890275 0.4473831336175571 0.6545984516308581 1.0 0.9449806721743932 2 P30533 1 +Negative regulation of mapk cascade 0.3133448672868256 0.4469606185555748 0.6549034945221317 1.0 0.9449806721743932 31 P04035,O00459,P18031,P04062,Q99956,Q14118,P57105,Q8NC56 8 +Regulation of dna helicase activity 0.6300930381777325 0.4460403853865288 0.6555680739175922 1.0 0.9449806721743932 3 P49736,Q04837 2 +Natural killer cell activation 0.4318759224560068 0.4459570922684941 0.6556282405030116 1.0 0.9449806721743932 7 P46379,Q5HYI8,O95251,P11279 4 +Regulation of transmembrane transport 0.2904227384039051 0.4450671319006309 0.6562712407003506 1.0 0.9449806721743932 73 Q8N668,P0CG08,Q96GC9,Q16625,Q04656,Q99623,Q15041,P21796,O75298,P31751,P23634,Q8TAD4,P08183,Q9BVC6,P52789,P05556,O75844,Q4KMQ2,O75915 19 +Negative regulation of intracellular estrogen receptor signaling pathway 0.4567481740148269 0.4414141935145894 0.658913168661782 1.0 0.9449806721743932 5 Q99623 1 +Response to testosterone 0.393951541286834 0.4408908815007533 0.6592919953177887 1.0 0.9449806721743932 10 P04062 1 +Cellular response to oxygen radical 0.4561404156964027 0.4389476671375134 0.6606994565356394 1.0 0.9449806721743932 5 P00374 1 +Response to oxygen radical 0.4561404156964027 0.4389476671375134 0.6606994565356394 1.0 0.9449806721743932 5 P00374 1 +Negative regulation of immunoglobulin production 0.6529826812058973 0.4383289444564121 0.6611478468156757 1.0 0.9449806721743932 2 Q96FV9 1 +Glial cell migration 0.3784988695857281 0.4377423121342619 0.6615730934368758 1.0 0.9449806721743932 12 Q96N66,O94901,P30536,Q9NQC3 4 +Negative regulation of reproductive process 0.4414076100555394 0.437266524115345 0.6619180698332616 1.0 0.9449806721743932 6 P00813 1 +Xenobiotic metabolic process 0.3783776712389208 0.4370428601652424 0.6620802651448079 1.0 0.9449806721743932 12 O43169,P16435 2 +Regulation of superoxide metabolic process 0.4553319624891488 0.4356720921585435 0.6630746567629018 1.0 0.9449806721743932 5 P00374 1 +Cerebral cortex radially oriented cell migration 0.4095711172056677 0.4345632257098352 0.6638794927165734 1.0 0.9449806721743932 8 Q96N66,Q9NQC3 2 +Telencephalon glial cell migration 0.4095711172056677 0.4345632257098352 0.6638794927165734 1.0 0.9449806721743932 8 Q96N66,Q9NQC3 2 +Rap protein signal transduction 0.500000000000006 0.4344840889565523 0.6639369464882088 1.0 0.9449806721743932 4 Q9Y4G8,Q15058,P35241 3 +Cell activation involved in immune response 0.3090219667618345 0.4329527436694474 0.6650491012466333 1.0 0.9449806721743932 37 Q96FZ2,Q9UQ84,O96028,Q04656,P00813,P09601,P11279,Q12846 8 +Immune effector process 0.2870912651081886 0.428311620315097 0.6684242598519012 1.0 0.947469496715839 71 O15400,P35232,P07437,Q08722,Q96FZ2,Q9UQ84,Q04656,O96028,P00813,Q99623,P09601,P46108,P11279,Q12846,Q8N5M9,P68371 16 +Pyramidal neuron development 0.4978822787312786 0.4268690760086744 0.6694746905382394 1.0 0.9481303863381872 4 O14949 1 +Regulation of exocytosis 0.3075028973379426 0.4226607926221823 0.6725427652518186 1.0 0.9501953497311874 39 P16615,P61026,Q9Y3E7,O00560,Q9P253,P09601,P11279,Q4J6C6,Q12846 9 +Regulation of calcium mediated signaling 0.3987302224472026 0.4208018567868534 0.6738997756810272 1.0 0.9514913753199714 9 P00813 1 +Organelle disassembly 0.298892355420471 0.4184570140135611 0.6756130089385517 1.0 0.952667170727428 51 O43464,Q709C8,P12235,Q9BWH2,P52789,Q96HY6,Q13501,Q9H300,P04062,Q99623,O95140,P30536,P21796,Q9Y6I9,Q13190 15 +Positive regulation of mrna splicing via spliceosome 0.3506643703438267 0.4152930956308043 0.6779273549589933 1.0 0.9541422694937544 16 Q13595,Q14011,P98179,P38159 4 +Amyloid fibril formation 0.4250739190831161 0.414460301011762 0.6785370350276823 1.0 0.9541422694937544 7 O15212,Q13546,Q9UHV9 3 +Regulation of production of molecular mediator of immune response 0.3187833998736726 0.4128681876754861 0.6797031897595887 1.0 0.9546121796151 27 P35232,Q96FZ2,P02786,O96028,Q99623,P09601,Q12846 7 +Sperm motility 0.449580748439459 0.4125542050425083 0.6799332591713219 1.0 0.9546121796151 5 P23634,Q9GZT3,Q96RL7 3 +Gdp metabolic process 0.4490969166786083 0.4106244376604053 0.6813479416397772 1.0 0.9553344691787784 5 Q14168,Q00013 2 +Folic acid containing compound catabolic process 0.6180724536160335 0.4090461919713597 0.6825057628537485 1.0 0.9553344691787784 3 Q8IYS1 1 +Establishment of protein localization to plasma membrane 0.3247681319918012 0.4087738214866842 0.6827056530432967 1.0 0.9553344691787784 23 P98194,Q9BZG1,P61026,Q9H4A6,Q15904 5 +Protein import 0.2993354708279204 0.4086481172875035 0.6827979137040501 1.0 0.9553344691787784 85 O75381,Q9NS69,Q99623,Q3ZCQ8,O43615,O60830,Q7Z3B4,P40855,P02545,O14925,Q9Y512,Q8NFH5,O00459,O95831,Q15388,O14737,P13473,O96008,P52292 19 +Regulation of mitotic cytokinesis 0.6430404105195596 0.4077693875409892 0.6834429901448005 1.0 0.9553414903498604 2 P37198 1 +Photoreceptor cell differentiation 0.4334324113601163 0.4028776515112494 0.6870382328226405 1.0 0.9576709317837178 6 P54802 1 +Synaptic vesicle membrane organization 0.4224339406044171 0.4023518521610835 0.6874250990605879 1.0 0.9578801766691 7 O95721 1 +Negative regulation of response to endoplasmic reticulum stress 0.359524262305321 0.399227554992842 0.6897255414886267 1.0 0.9586836890345964 14 P18031,Q96HY6,O76024,O60313 4 +Establishment of planar polarity involved in neural tube closure 0.6401539448364294 0.3990845506530914 0.6898309054702203 1.0 0.9586836890345964 2 Q13308 1 +Planar cell polarity pathway involved in neural tube closure 0.6401539448364294 0.3990845506530914 0.6898309054702203 1.0 0.9586836890345964 2 Q13308 1 +Regulation of insulin secretion involved in cellular response to glucose stimulus 0.3943670365240683 0.3987375561518848 0.6900865920922774 1.0 0.9586836890345964 9 Q8N5M9 1 +Positive regulation of leukocyte degranulation 0.4897727584685731 0.398106571414123 0.6905516306108568 1.0 0.9586836890345964 4 Q12846,P11279 2 +Sensory system development 0.3053767139105054 0.3967426261811206 0.6915572632479159 1.0 0.9595804504811332 35 Q8NF37,O75569,P08670,P20020,Q8NBN7,P48681,P23634,Q16706,O95140,P54802,O43819 11 +Regulation of autophagy of mitochondrion 0.336653879124309 0.3890761364755051 0.6972198257611422 1.0 0.963013410265756 18 O43464,P12235,Q709C8,Q9H300,P30536,P21796 6 +Regulation of chemotaxis 0.3188931576247423 0.384900596574647 0.7003110638890129 1.0 0.963013410265756 25 P27361,Q9BVA1,Q8NHP6,Q00013,P04792,Q4KMQ2,Q12846,Q9NUQ9,Q13641,Q8NE86 10 +Formation of extrachromosomal circular dna 0.4859696491088269 0.3848436554558566 0.700353253039933 1.0 0.963013410265756 4 Q9UQ84 1 +Positive regulation of torc1 signaling 0.4851185558248564 0.3818959694866234 0.7025385300035056 1.0 0.963013410265756 4 Q9NWS0 1 +Immunoglobulin production involved in immunoglobulin mediated immune response 0.349785402080466 0.3808663171938942 0.7033024470960871 1.0 0.963013410265756 15 Q96FZ2,Q9UQ84,O96028 3 +Somatic diversification of immunoglobulins involved in immune response 0.349785402080466 0.3808663171938942 0.7033024470960871 1.0 0.963013410265756 15 Q96FZ2,Q9UQ84,O96028 3 +Phosphatidylinositol 3 kinase signaling 0.3626047628805631 0.3799627142525644 0.7039730928473555 1.0 0.9630584054200428 13 O00459,Q10713,Q8IXJ6 3 +Regulation of cardiac muscle cell action potential 0.3978817527164698 0.3780571040104439 0.705388173540642 1.0 0.963674247185574 8 P16615 1 +Regulation of nuclear transcribed mrna catabolic process nonsense mediated decay 0.4404494382022511 0.3765479694808467 0.7065095605172775 1.0 0.9639615027716688 5 Q99729,P38919,P11940,A2RRP1 4 +Sodium ion transport 0.3143964158298024 0.3763819335929204 0.7066329751487386 1.0 0.9639615027716688 27 Q8N668,P05026,P08195,P05023,P23634,Q6P4Q7,P54709,Q4KMQ2,Q9Y6M7 9 +Regulation of establishment of protein localization to mitochondrion 0.3287833496092351 0.3725521518740286 0.7094817902331783 1.0 0.9664756951418664 19 O43464,O14737,Q9Y371,Q9H300,P49840,P55786,Q9BZL1,P49257 8 +Deoxyribose phosphate metabolic process 0.3609703443218396 0.3704202170508925 0.711069412435338 1.0 0.9673071195929838 13 P00813 1 +Epithelial cell apoptotic process 0.3666116732093774 0.369950720771003 0.7114192085215203 1.0 0.9673071195929838 12 P09601 1 +Regulation of multicellular organism growth 0.3665070298286433 0.3693617210872116 0.7118581260006835 1.0 0.9673071195929838 12 O75844 1 +Mitochondrial electron transport nadh to ubiquinone 0.318343559408758 0.368954016104328 0.7121620001724585 1.0 0.9673071195929838 24 Q9Y6M9,O96000,O95169,P09622 4 +Regulation of neurotransmitter transport 0.338764467175175 0.3686183136986652 0.7124122430848434 1.0 0.9673071195929838 17 P16615,P41440,P05556,Q9P253,Q4J6C6 5 +Golgi to plasma membrane protein transport 0.3426797710828234 0.3634494281071643 0.7162691841469253 1.0 0.969678882185277 16 P98194,P61026,Q9BZG1,Q9H4A6 4 +Pore complex assembly 0.3594329546365281 0.3614773265254592 0.7177426515834171 1.0 0.969678882185277 13 Q8N1F7,Q9BTX1,Q9NQC3 3 +Negative regulation of autophagosome assembly 0.4788189987163108 0.3603165799798755 0.7186104018343944 1.0 0.9696983431113884 4 O75396,Q8WVM8,Q9H444 3 +Glial cell proliferation 0.4782388138461246 0.35835068012314 0.7200808956320117 1.0 0.9708658049920974 4 P04062 1 +Regulation of atp biosynthetic process 0.4227865143639639 0.3579889713118609 0.7203515669754279 1.0 0.9708658049920974 6 P00403 1 +Negative regulation of nervous system development 0.3370688396380222 0.3573731687858809 0.7208124605216493 1.0 0.9708658049920974 17 Q15375,P30536,Q9NQC3,Q8IXJ6 4 +Positive regulation of autophagy 0.300717146117011 0.3567617887883371 0.7212701444049423 1.0 0.9708658049920974 32 O15269,P21796,P09601,Q86UE4 4 +Regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway 0.376927968569559 0.3514448107046624 0.7252546695966471 1.0 0.9742092520218152 10 O76024,O60313 2 +Multicellular organism growth 0.3172292896725303 0.3505825818748187 0.7259015257958479 1.0 0.9743189365650696 23 O95470,O75844 2 +Oocyte maturation 0.4332534212596851 0.3488206840734823 0.7272239339611257 1.0 0.9743189365650696 5 Q15645 1 +Activated t cell proliferation 0.4752888318356952 0.3484125226114707 0.7275303993145348 1.0 0.9743189365650696 4 P23396,P09429,P10644 3 +Apoptotic process involved in development 0.4752888318356915 0.3484125226114584 0.7275303993145441 1.0 0.9743189365650696 4 P30154,O75312,O94813 3 +Regulation of leukocyte migration 0.3126767407150607 0.3478738600416319 0.7279349172764671 1.0 0.9743189365650696 26 Q5JRA6,Q8NE86,Q00013,Q08722,P00813,P09601,P46108,Q4KMQ2,Q11206,Q8NHP6 10 +T cell activation 0.2901312649058357 0.3467517929221652 0.7287777962717161 1.0 0.9743189365650696 53 O96005,Q08722,P30825,Q92542,P00813,P04062,P78310,P24390 8 +Positive regulation of phagocytosis 0.4193099659793177 0.3436024103361231 0.7311453117805324 1.0 0.9756470048658354 6 Q08722,Q4KMQ2 2 +Protein localization to cell surface 0.3347399327710161 0.342003106970337 0.7323485540755261 1.0 0.9756470048658354 17 Q8N668,Q15907,Q12846,Q92643 4 +Very low density lipoprotein particle assembly 0.6202694034637681 0.341675364546334 0.7325952137669347 1.0 0.9756470048658354 2 P35610 1 +Regulation of translational initiation in response to stress 0.4187304072837862 0.3412178121894872 0.7329396149034926 1.0 0.9756470048658354 6 Q15363 1 +Mitotic dna replication 0.3665485372613835 0.3411751147575319 0.7329717561425295 1.0 0.9756470048658354 11 O75844 1 +Positive regulation of atp metabolic process 0.4183575220788534 0.3396856768806529 0.7340932492435228 1.0 0.9756470048658354 6 P00403 1 +Positive regulation of glucose import 0.4306202486182104 0.338825827058539 0.7347409437444654 1.0 0.9756470048658354 5 Q16625 1 +Anatomical structure homeostasis 0.298777945989394 0.3382813432110305 0.7351511818139793 1.0 0.9756854009892838 39 O14773,Q8NF37,P13473,P38571,P20020,Q16625,P10253,P23634,P51790,P78310 10 +Negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway 0.3659924890915098 0.3381890456049887 0.7352207303819434 1.0 0.9756854009892838 11 Q92896,Q9Y2U8 2 +Cellular hyperosmotic response 0.4079774051957372 0.3373179425285273 0.735877235323267 1.0 0.9763570430653278 7 O95202 1 +Protein k11 linked ubiquitination 0.3810276733793466 0.3326573807495849 0.7393929241415929 1.0 0.9782227152083188 9 Q9UJX3,Q16763,Q9UJX6,Q9UJX5 4 +Mitochondrion localization 0.3366743229082211 0.3250885193829074 0.7451140776771874 1.0 0.9825102439762944 16 P07196,O60313 2 +Regulation of dopamine uptake involved in synaptic transmission 0.6141757536882739 0.324966434057477 0.7452064758686496 1.0 0.9825102439762944 2 O14656 1 +Neuroepithelial cell differentiation 0.4675677275383136 0.3228686838508257 0.7467946938654997 1.0 0.9835631760876355 4 P07437 1 +Fluid transport 0.6132135984605467 0.3223675652044106 0.7471742529606213 1.0 0.9835631760876355 2 Q99797 1 +Regulation of dna dependent dna replication initiation 0.4669448010269654 0.3208381232129705 0.748333067255387 1.0 0.9842338477759264 4 P24941,Q9ULV3,O95251 3 +Negative regulation of inflammatory response 0.3570190174837848 0.3165887526846257 0.7515556711787985 1.0 0.9868449451714664 12 P00813 1 +Negative regulation of peptide secretion 0.4242466730461829 0.314984735089609 0.7527732440117132 1.0 0.9878722256163416 5 Q8N5M9 1 +Negative regulation of hormone secretion 0.4242466730461829 0.314984735089609 0.7527732440117132 1.0 0.9878722256163416 5 Q8N5M9 1 +Response to osmotic stress 0.3203515442412796 0.313380273105993 0.7539917697483407 1.0 0.9879215557237628 19 P08183,O95202,P30536 3 +Regulation of meiotic nuclear division 0.5816920682040655 0.3050500482467294 0.7603280347245631 1.0 0.9911780731819888 3 Q15645 1 +Negative regulation of fatty acid biosynthetic process 0.4212473468504674 0.303943391630245 0.7611710188835117 1.0 0.9911780731819888 5 O94905 1 +Protein deneddylation 0.3749901939321515 0.3035066342978857 0.7615037923360413 1.0 0.9911780731819888 9 Q9BT78,Q99627 2 +Receptor internalization 0.3119140306022078 0.3029139232560517 0.7619554603356586 1.0 0.9911780731819888 22 P41440,Q9UHD9,O00560,P05556,Q8IZ07,P02786 6 +Regulation of nervous system process 0.3673661658526781 0.3028123736011018 0.7620328531155984 1.0 0.9911780731819888 10 O75746,Q14118,P04062 3 +Bleb assembly 0.461336351458837 0.3027661341769633 0.7620680937834241 1.0 0.9911780731819888 4 Q9NR77 1 +Dopamine metabolic process 0.4091846253693967 0.3025317549403664 0.7622467299103064 1.0 0.9911780731819888 6 P21964 1 +Regulation of mitochondrial membrane permeability 0.3431974716112319 0.30148899870933 0.7630416377483669 1.0 0.9911780731819888 14 P05141,P12235,P45880,P52789 4 +Regeneration 0.296951127914025 0.3004608145089426 0.7638256818519298 1.0 0.9911780731819888 31 P09601,P30536,P00374,P07196,P50416 5 +Ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway 0.3484679532094596 0.2986999264517936 0.7651690131742859 1.0 0.9911780731819888 13 Q92783,Q9Y3E7,Q9H9H4,Q9UQN3 4 +Endothelial cell migration 0.2947996894820748 0.2980189225573564 0.7656887213645516 1.0 0.9911780731819888 36 P09601,Q8WTV0,P42785 3 +Cellular response to inorganic substance 0.294687041796404 0.2969760214969228 0.7664848158053736 1.0 0.9911780731819888 36 Q6NUK1,P27361,O95831,Q92542,Q04656,Q14103,P09601,P35611,P30536,P55011,P46108,O75131,Q14168 13 +Embryo implantation 0.3735937854251209 0.2968376820541043 0.766590435219773 1.0 0.9911780731819888 9 P35613 1 +Regulation of histone h3 k9 trimethylation 0.4165201594111695 0.2867815707077307 0.774279574940808 1.0 0.9965540410877995 5 Q9NWS0 1 +Negative regulation of alpha beta t cell differentiation 0.5745909528392767 0.2862893279430409 0.7746565312821161 1.0 0.9965540410877995 3 P04083,P09429 2 +Negative regulation of cd4 positive alpha beta t cell differentiation 0.5745909528392767 0.2862893279430409 0.7746565312821161 1.0 0.9965540410877995 3 P04083,P09429 2 +Regulation of cd4 positive alpha beta t cell differentiation 0.5745909528392767 0.2862893279430409 0.7746565312821161 1.0 0.9965540410877995 3 P04083,P09429 2 +Muscle adaptation 0.3209902089321876 0.2830086289175608 0.7771702223853485 1.0 0.997703991244944 18 P16615,P50750,P23634,P09601,Q14118 5 +Lipid metabolic process 0.4264808678723519 0.2814330429906466 0.7783782771968213 1.0 0.9983863717408704 268 O14773,Q9NPH0,Q9UBV2,Q13510,P51648,P50897,Q9HB40,Q10713,Q9NX62,Q9H6K4,Q8NHP8,P17900,Q8NBX0,Q9H6V9,P21964,O75844,Q8WTV0,O95470,Q16850,Q9BWD1,P16278,Q8NCC3,Q9BT22,O15118,O95749,Q99623,Q86YN1,P23786,P50416,P06280,Q8NF37,Q14534,Q8NBN7,Q53H12,Q9BVG9,Q9NZD2,Q11206,P35790,Q99805,P05023,Q9NZC3,Q9NZJ7,P37268,Q96E52,P38571,Q5H8A4,Q15800,P04066,P38435,P06865,Q53GQ0,Q13011,Q9H7Z7,Q9UG56,P04062,O15269,Q12770,Q96N66,P16435,P07099,Q9P035,Q9BY49,O94905,P30536,Q9BV10,O75845,Q8NCG7,Q9H6U8,O00116,Q15067,Q9Y394,Q9NTJ5,Q06136,Q15392,Q92643,Q8N2A8,A1L0T0,P04035,O75477,O95674,Q8IXJ6,O00459,P09960 83 +Cellular response to epinephrine stimulus 0.5722405653501699 0.2801983865948101 0.7793253044245814 1.0 0.9983863717408704 3 P23634 1 +Response to epinephrine 0.5722405653501699 0.2801983865948101 0.7793253044245814 1.0 0.9983863717408704 3 P23634 1 +Skeletal system development 0.2892024957395805 0.2789772826992102 0.7802622586909855 1.0 0.9988946114322798 47 Q92896,Q7RTS9,Q32P28,O95470,P16435,Q15043,Q04656,Q9NX62,O75844,Q15904 10 +Sterol transport 0.3084332054443353 0.2772756320361454 0.7815684691049001 1.0 0.9996016025742652 22 Q8WTV0,O15118 2 +Response to potassium ion 0.4531689870394708 0.2771453635742579 0.7816684904114892 1.0 0.9996016025742652 4 Q14168 1 +Cellular response to potassium ion 0.4531689870394708 0.2771453635742579 0.7816684904114892 1.0 0.9996016025742652 4 Q14168 1 +Regulation of hormone secretion 0.3052006266479196 0.277022756288467 0.7817626326964584 1.0 0.9996016025742652 25 Q12846,Q8N5M9,Q8NE86,P50416 4 +Protein maturation by protein folding 0.4137005665330659 0.2766890706497664 0.7820188647243493 1.0 0.9996016025742652 5 O76024 1 +Inflammasome complex assembly 0.4530138706691097 0.276666992029586 0.782035819389201 1.0 0.9996016025742652 4 Q8IXJ6 1 +Regulation of long term synaptic potentiation 0.4021591593503935 0.2748107776449081 0.7834616174292679 1.0 1.0 6 Q9BPZ3,Q92542 2 +Progesterone receptor signaling pathway 0.4520679584770377 0.2737565994213276 0.7842716785001906 1.0 1.0 4 Q05086 1 +Heart morphogenesis 0.305643152063375 0.2710207125152271 0.786375101951085 1.0 1.0 24 O75844,Q9NQC3 2 +Intrinsic apoptotic signaling pathway in response to dna damage 0.3075029853057142 0.2704685710166761 0.7867997928707244 1.0 1.0 22 Q9BVC6,P61978,Q96K76,Q96RU2,P46379,P09601,Q07820 7 +Regulation of anoikis 0.4118238856183953 0.2700326925734553 0.7871351024903099 1.0 1.0 5 Q07820,Q9Y3E5 2 +Cardiac muscle cell action potential 0.3276283433171365 0.2684824595814008 0.7883279746401497 1.0 1.0 16 P16615,P05023 2 +Regulation of mitochondrial atp synthesis coupled electron transport 0.5669741956885067 0.2667692966253923 0.7896467955302793 1.0 1.0 3 Q9H3K2 1 +Male sex differentiation 0.3069523651432354 0.2664484562043862 0.7898938508716284 1.0 1.0 22 O95470 1 +Defense response to gram positive bacterium 0.4495297239623955 0.2660046982553248 0.7902355906612899 1.0 1.0 4 P04439 1 +Ribonucleoside triphosphate metabolic process 0.2912804788479772 0.2654335579977461 0.7906754874470949 1.0 1.0 37 P24539,O75746,O60313,Q9UJS0,P00403,P56385,P00846,O75964 8 +Regulation of dendrite extension 0.566249598973381 0.2649454980343666 0.7910514479789184 1.0 1.0 3 Q9Y263,Q96PU5 2 +Zymogen activation 0.3662913825385826 0.2624390153231726 0.7929829965715434 1.0 1.0 9 Q96E52,Q9BXI6 2 +Detection of stimulus 0.3418819581751174 0.261929223037649 0.7933760091983235 1.0 1.0 13 P04439,Q8WTV0,P30536,P01889 4 +Regulation of viral entry into host cell 0.4093097913322672 0.2611933227670047 0.793943427106842 1.0 1.0 5 P19474,Q14258,P07237,O60493 4 +Prostanoid biosynthetic process 0.3899927307467281 0.2598603970460189 0.7949714606257441 1.0 1.0 7 Q9H7Z7 1 +Myoblast migration 0.5885182809493208 0.259483374611956 0.7952623079847816 1.0 1.0 2 Q13464 1 +Toll like receptor signaling pathway 0.3462243610873264 0.2582320377811736 0.7962278336211153 1.0 1.0 12 P41440,Q9NQC3 2 +Neutrophil clearance 0.5878768441308475 0.2579507936439988 0.7964448832783506 1.0 1.0 2 P04083 1 +Neutrophil homeostasis 0.5878768441308475 0.2579507936439988 0.7964448832783506 1.0 1.0 2 P04083 1 +Regulation of dna ligation 0.5878768441308475 0.2579507936439988 0.7964448832783506 1.0 1.0 2 P18887 1 +Positive regulation of dna ligation 0.5878768441308475 0.2579507936439988 0.7964448832783506 1.0 1.0 2 P18887 1 +Vascular endothelial growth factor receptor signaling pathway 0.3716905584560984 0.2575401248937118 0.796761844427688 1.0 1.0 8 P18031,P04792,O14964 3 +Cellular response to vitamin d 0.4464701513832257 0.2567738532342676 0.7973533555694285 1.0 1.0 4 P20020 1 +Cell volume homeostasis 0.4079954994599863 0.2566083472840013 0.7974811305347504 1.0 1.0 5 P51790,Q4KMQ2 2 +Regulation of response to wounding 0.312028330364988 0.25630699856892 0.7977137936362395 1.0 1.0 19 Q16625,Q04656,P05556,P46108,Q4KMQ2,Q11206 6 +Positive regulation of blood vessel endothelial cell migration 0.3497073631816531 0.2528037369730755 0.8004198797989006 1.0 1.0 11 P09601 1 +Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.2890371932210408 0.2519580610868865 0.8010734805765276 1.0 1.0 32 P04439,P01889,O15400,P35232,Q96FZ2,Q9UQ84,O96028,P00813,P02786,Q9NUQ9 10 +Biological process involved in interaction with host 0.2780133441933485 0.2517905689968269 0.8012029473713467 1.0 1.0 56 P07237,P06493,O15118,Q9UPT5,P35613,P11279,Q14108,P08195,P35232,Q9BTY2,Q9Y3E7,P78310,Q9UQN3,Q9HD42,P05556,Q9H9H4,Q8WTV0,Q15758,Q9P253,Q14118,P02786 21 +Response to antibiotic 0.3632946703083973 0.2485647634483817 0.8036974678307711 1.0 1.0 9 P50416 1 +Multi multicellular organism process 0.3014872958397589 0.2484431068359737 0.8037915843863983 1.0 1.0 25 P07686,P41440,Q15363,Q96GC9,Q04656,P35613,Q9UIQ6 7 +Regulation of nucleobase containing compound transport 0.3559485530546671 0.2465375809509627 0.8052661165994177 1.0 1.0 10 Q96ST2,P12270,Q16630,Q07666,Q08211,Q7KZ85,Q08J23,Q13546,Q9ULX6 9 +Regulation of nucleotide biosynthetic process 0.3690951165708028 0.2461345153700619 0.805578105370536 1.0 1.0 8 O75746,Q15120,P00403 3 +Positive regulation of reactive oxygen species metabolic process 0.3333896344096025 0.2448836193753746 0.8065465454429952 1.0 1.0 14 P04899,P62993,P30536,P51790,P00403 5 +Positive regulation of leukocyte cell cell adhesion 0.302128462911466 0.2445260695781074 0.8068234140518475 1.0 1.0 24 P00813,P30825,Q11206 3 +Response to misfolded protein 0.3624002428583216 0.2444521869641036 0.8068806280571681 1.0 1.0 9 P46379,Q9BUN8 2 +Development of primary female sexual characteristics 0.3549520165414813 0.2417275173263133 0.808991306019682 1.0 1.0 10 O95470 1 +Female sex differentiation 0.3549520165414813 0.2417275173263133 0.808991306019682 1.0 1.0 10 O95470 1 +Snorna localization 0.4413390644996579 0.2415765260869358 0.8091083128854002 1.0 1.0 4 Q9NWS0 1 +Negative regulation of b cell activation 0.580500320718413 0.2407040094617888 0.8097845312250986 1.0 1.0 2 Q96FV9 1 +Sequestering of triglyceride 0.5561920291068291 0.2402395688010794 0.8101445402497294 1.0 1.0 3 Q9BXB4 1 +Regulation of sequestering of triglyceride 0.5561920291068291 0.2402395688010794 0.8101445402497294 1.0 1.0 3 Q9BXB4 1 +Negative regulation of neuron death 0.2867235848991737 0.2373505931072399 0.8123848155992048 1.0 1.0 44 Q9UMX5,P50897,P04062,P09601,O76024,P07196 6 +Membrane biogenesis 0.2985389268006641 0.2358580411190009 0.8135428280799761 1.0 1.0 26 P41440,Q8IXJ6,Q86XL3,Q9Y3E7,Q96CP7,Q12846,O75955,Q9H6H4,Q9UQN3 9 +Hyperosmotic response 0.3664389381269798 0.234574131643085 0.8145392893361252 1.0 1.0 8 O95202 1 +Vesicle localization 0.267909819526932 0.2340601662995146 0.8149382697038665 1.0 1.0 62 Q13561,Q92783,Q9UBV8,Q96A57,Q15363,Q9BVK6,Q9Y3E7,Q9NR31,O00560,O95721,P49755,Q15907,O95772 13 +Entry of bacterium into host cell 0.4383316116868705 0.232837276448788 0.8158877658795205 1.0 1.0 4 Q9BTY2 1 +Regulation of entry of bacterium into host cell 0.4383316116868705 0.232837276448788 0.8158877658795205 1.0 1.0 4 Q9BTY2 1 +Inflammatory response 0.2676980301126979 0.2315109085541493 0.8169179118113665 1.0 1.0 62 P38571,Q8IV08,Q08722,P00813,P42785,P09601 6 +Lysosomal transport 0.2871312090535957 0.2313823105088832 0.8170178064974369 1.0 1.0 41 Q14108,P13473,O15118,Q9P253,P11279,Q9NZJ7,P20645 7 +Regulation of synapse assembly 0.3823815386256525 0.2284085203070389 0.8193286662644288 1.0 1.0 7 Q13641 1 +Nonribosomal peptide biosynthetic process 0.4367779204107907 0.2283719732680618 0.8193570758828566 1.0 1.0 4 Q8WUX2,P48506,Q99735 3 +Carbohydrate derivative biosynthetic process 0.3461391887372087 0.2270373777458245 0.8203946777294666 1.0 1.0 155 Q7LGA3,Q9BT22,O15118,P46977,Q04656,Q02127,Q92643,Q86YN1,Q96L58,O75964,Q10472,P24539,O75746,P50897,Q92542,Q9UJS0,Q8NCH0,Q96JB2,P00846,Q11206,O60476,Q99805,Q8NBX0,Q8TB61,P00813,Q9H4A6,Q9BV10,P56385,P00403,O43505,Q9UMR5,P09622,Q8WVC6,Q5H8A4,Q9H6U8,P06865,Q53GQ0 37 +Animal organ regeneration 0.3208276761216848 0.226979758272456 0.8204394819701086 1.0 1.0 16 P09601 1 +Positive regulation of cold induced thermogenesis 0.3298602865120216 0.2249639157281837 0.8220073458317787 1.0 1.0 14 Q96E52,O95140,Q16836,P23786 4 +Cellular response to acid chemical 0.3347744271556743 0.2231346966376307 0.8234306750087974 1.0 1.0 13 Q99729,Q9UQB8,Q04656 3 +Negative regulation of transforming growth factor beta receptor signaling pathway 0.3637481369467468 0.2229818642065411 0.8235496214416607 1.0 1.0 8 Q9Y2U8 1 +Cardiolipin acyl chain remodeling 0.5724823604874861 0.2227554979097714 0.8237258052631407 1.0 1.0 2 Q6UWP7 1 +Extracellular transport 0.547962784728912 0.220887736734047 0.8251798462613766 1.0 1.0 3 Q99816,Q7Z494 2 +Peripheral nervous system development 0.3433858477298843 0.2208556802316755 0.8252048073095415 1.0 1.0 11 Q9NR77,P51648,Q14118 3 +Regulation of intrinsic apoptotic signaling pathway 0.2808484551996673 0.2160240570985798 0.828968995419598 1.0 1.0 50 O43464,O75569,P07237,Q15233,P61978,P23246,Q96K76,P45880,Q9H300,Q9P0J0,O60313,P51572,P04792,O76024,P30040,P18031,Q07820 17 +Regulation of rna export from nucleus 0.3558341369334484 0.2146774737840693 0.830018786428735 1.0 1.0 9 Q96ST2,P12270,Q16630,Q07666,Q08211,Q7KZ85,Q08J23,Q9ULX6 8 +Blood vessel endothelial cell migration 0.2980904986804696 0.2144606283766609 0.8301878666692257 1.0 1.0 24 Q8WTV0,P42785 2 +Reproductive system development 0.2707193023379323 0.2138871040126916 0.8306350970389693 1.0 1.0 59 Q15363,O95470,P36639,P00813,P35613 5 +Head morphogenesis 0.3859618000740418 0.2135769731511632 0.8308769578243829 1.0 1.0 6 O95470 1 +Regulation of presynaptic cytosolic calcium ion concentration 0.5441665199159331 0.2122281481996016 0.8319290477928245 1.0 1.0 3 P20020 1 +Cellular carbohydrate catabolic process 0.3053554054647804 0.2116593763544843 0.8323727829687304 1.0 1.0 19 Q14108,Q9NUJ1,P08236 3 +Positive regulation of protein secretion 0.3002055130014116 0.2109281065404045 0.8329433716476013 1.0 1.0 20 Q8NE86,P49755,Q9H4A6 3 +Negative regulation of mitochondrial fusion 0.4305030784379955 0.2106872656841418 0.8331313120816937 1.0 1.0 4 P02786,Q96E52 2 +Inositol lipid mediated signaling 0.3178649007787032 0.2092107723543505 0.8342837033760511 1.0 1.0 16 O00459,Q10713,Q8IXJ6 3 +Negative regulation of canonical wnt signaling pathway 0.2998407226062363 0.2084316332660192 0.83489195889372 1.0 1.0 20 P50402 1 +Response to extracellular stimulus 0.2837125576311783 0.2050621675463036 0.8375235542082389 1.0 1.0 86 Q96E52,Q9UMX5,P80303,P13473,Q9H773,P16435,P36639,Q9Y371,O95831,P04062,P09601,P30536,P21964,P50416 14 +Calcium ion regulated exocytosis 0.3470393182698068 0.2041618293801642 0.8382270388273563 1.0 1.0 10 P51809,P16615,P04899,Q9BRK5 4 +Positive regulation of protein localization to membrane 0.2858076894852716 0.204123295822507 0.8382571501432214 1.0 1.0 31 P98194,O14737,Q9GZY8,P05556,P23634,O15258,Q12846,O00264,P31751 9 +Ephrin receptor signaling pathway 0.3832433644644961 0.2036931856571105 0.8385932676189891 1.0 1.0 6 Q15375,P46108 2 +Negative regulation of striated muscle cell differentiation 0.391653290529699 0.2017598564865242 0.8401044659799042 1.0 1.0 5 P67809,P11413,P49840,O94826 4 +Lung associated mesenchyme development 0.5618986529826749 0.2003564205343703 0.8412018397708312 1.0 1.0 2 Q13308 1 +Regulation of synaptic vesicle exocytosis 0.3389858757369957 0.1990610024238754 0.8422150262595405 1.0 1.0 11 Q9P253,P16615 2 +Positive regulation of calcium ion transport 0.3121249319618914 0.1980660216400067 0.842993408953552 1.0 1.0 17 Q96GC9,O76024,P30536 3 +Synaptic transmission gabaergic 0.3904586774830354 0.1979139917001829 0.8431123569150383 1.0 1.0 5 Q13641 1 +Positive regulation of centriole replication 0.5606157793457283 0.1977422969115751 0.8432466949234234 1.0 1.0 2 P37198 1 +Embryonic brain development 0.3892997322707532 0.1942050745391671 0.846015309609828 1.0 1.0 5 Q9BVA1 1 +Cellular response to osmotic stress 0.3292429621356998 0.1936389401472823 0.8464586054037275 1.0 1.0 13 O95202,P30536,Q9BPX6 3 +Lipophagy 0.3885819193557664 0.1919188823048625 0.8478057464372963 1.0 1.0 5 O15269 1 +Dna replication checkpoint signaling 0.4229781771502031 0.1902346069722362 0.8491252938042106 1.0 1.0 4 P51530,Q13564,O60921 3 +Cellular response to vitamin 0.3862412094582465 0.1845227318160497 0.8536033959173379 1.0 1.0 5 P20020 1 +Positive regulation of activated t cell proliferation 0.5532392559332842 0.1831372314220044 0.8546903433084543 1.0 1.0 2 P09429 1 +Cell cell adhesion mediated by cadherin 0.3710247349823325 0.1831343178327648 0.8546926293575188 1.0 1.0 7 P41440,P19022,O60716,P49593,Q07157,O75955 6 +Cardiac muscle cell contraction 0.3263296310663605 0.1783660251149375 0.8584355294575143 1.0 1.0 13 P16615 1 +Membrane repolarization during cardiac muscle cell action potential 0.4178040566720047 0.1766617471869596 0.8597740895235939 1.0 1.0 4 P05023 1 +Membrane repolarization during action potential 0.4178040566720047 0.1766617471869596 0.8597740895235939 1.0 1.0 4 P05023 1 +Response to vitamin d 0.3834894235865529 0.1759441566403423 0.860337814441432 1.0 1.0 5 P20020 1 +Acetyl coa biosynthetic process from pyruvate 0.3522089403515479 0.1747022345168203 0.8613136118890146 1.0 1.0 8 P09622,Q15120 2 +Cardiac chamber development 0.299629586344406 0.1742359233882852 0.8616800545203602 1.0 1.0 19 O75844 1 +Late endosome to vacuole transport 0.351972499443108 0.1737383750063695 0.8620710772440936 1.0 1.0 8 Q92783,Q9Y3E7,Q9UQN3 3 +Positive regulation of synaptic transmission 0.308027211185625 0.173198111863851 0.8624957077282307 1.0 1.0 17 Q9BPZ3,P41440,Q92542,Q12846,Q14168,O75955 6 +Regulation of coagulation 0.4163287423224232 0.1728661926993406 0.8627566058619618 1.0 1.0 4 Q11206 1 +Regulation of platelet derived growth factor receptor signaling pathway 0.5477870429762604 0.1728101467952445 0.862800661053531 1.0 1.0 2 O14964 1 +Negative regulation of platelet derived growth factor receptor signaling pathway 0.5477870429762604 0.1728101467952445 0.862800661053531 1.0 1.0 2 O14964 1 +Translational readthrough 0.5474663245670237 0.1722150788011151 0.8632684438168066 1.0 1.0 2 P38919 1 +Error free translesion synthesis 0.5461834509300802 0.1698485975106689 0.8651292068571361 1.0 1.0 2 Q9Y2S7 1 +Cdp diacylglycerol metabolic process 0.36746144245601 0.1693661158630617 0.8655086740687608 1.0 1.0 7 Q86UL3,Q9NUQ2,O95674,Q6UWP7 4 +Response to calcium ion 0.2932542424116782 0.1639792106463379 0.8697475097676637 1.0 1.0 20 Q6NUK1,Q9UBV8,O75746,Q92542,P35611,Q9UJS0,Q14103 7 +Leukocyte chemotaxis 0.2890634516662236 0.1635345124109079 0.8700976019206224 1.0 1.0 26 P27361,Q8NE86,Q00013,P35613,P55011,Q4KMQ2,P78310,Q8NHP6 8 +Inner ear receptor cell development 0.3493859707077756 0.163263799079196 0.8703107355734028 1.0 1.0 8 Q9Y6M7,P54802 2 +Intrinsic apoptotic signaling pathway 0.2693380410614402 0.1597168422521596 0.8731041330233964 1.0 1.0 75 P07237,Q15118,Q9H300,Q9P0J0,P18031,O75569,P61978,P23246,P45880,O43464,Q9BVC6,Q9NR28,O95831,O60313,P51572,Q07820,Q15233,Q96K76,Q96RU2,P46379,P09601,O76024,Q96HE7,O75915 24 +Tissue migration 0.2737377478353201 0.159643554376754 0.8731618675253483 1.0 1.0 52 P09601,Q8WTV0,P42785,Q9NQC3 4 +Ether biosynthetic process 0.3780416286537612 0.1593392398594888 0.8734016067224091 1.0 1.0 5 Q8WVX9,O00116 2 +Establishment of mitochondrion localization 0.3424041333304338 0.156231411732137 0.8758506177511167 1.0 1.0 9 P07196 1 +Histone h4 k16 acetylation 0.342208006900251 0.1554039627824877 0.876502860271648 1.0 1.0 9 O75844 1 +Metencephalon development 0.2800015711875497 0.1552991670637538 0.8765854722355795 1.0 1.0 31 Q9BRK5,Q92542,Q04656,P04062,P46108,P54802,O14949 7 +Oocyte differentiation 0.3467007279658816 0.1525263244726283 0.8787718294098652 1.0 1.0 8 Q8N2A8,Q15645 2 +Positive regulation of peptidyl threonine phosphorylation 0.375601926163728 0.1520689554231001 0.8791325493854683 1.0 1.0 5 P28482,P61086,P53350,Q9C0C2 4 +Vacuolar transport 0.2765009982347543 0.1515409260519839 0.8795490292746915 1.0 1.0 47 Q14108,P13473,Q9Y3E7,O15118,P11717,P20645,Q9P253,P11279,Q9H9H4,Q9NZJ7,Q9UQN3 11 +Extracellular matrix assembly 0.3675410918251232 0.1490140702406267 0.8815425304784039 1.0 1.0 6 Q14118 1 +Amine metabolic process 0.2997582064269518 0.1474319427049267 0.8827910943628308 1.0 1.0 18 P21964,Q9NZC3,Q04656 3 +Neuronal stem cell population maintenance 0.3736757624398115 0.1464026787869709 0.883603512730871 1.0 1.0 5 Q9BXP5,Q9NZI8,Q9BXW9,Q15154 4 +Replication fork processing 0.3399761037927172 0.1460431566501048 0.8838873195587864 1.0 1.0 9 P51530,Q86V81,Q96FV9,P50750 4 +Protein kinase c signaling 0.405424955768552 0.1458592885844364 0.8840324707986369 1.0 1.0 4 P41440 1 +Negative regulation of apoptotic signaling pathway 0.259328020263177 0.1458029969542496 0.8840769099623247 1.0 1.0 66 P45880,Q9H300,O60313,Q9P0J0,P09601,O76024,Q07820,Q9NWS0 8 +Adaptive thermogenesis 0.2883635327546256 0.1438742088773239 0.8855998021034781 1.0 1.0 24 Q96E52,P12235,Q16836,O95140,P05141,Q9UIQ6,P23786 7 +Positive regulation of type i interferon mediated signaling pathway 0.510426692332373 0.1429552342496481 0.886325535870198 1.0 1.0 3 P61086,Q7Z434 2 +Regulation of biological process involved in symbiotic interaction 0.338674448068031 0.1406315152557092 0.888161050075603 1.0 1.0 9 Q9UPT5,Q9BTY2,P07237 3 +Attachment of spindle microtubules to kinetochore 0.3025354070206474 0.1405555943167796 0.8882210304787632 1.0 1.0 17 Q9HBM1,Q8IXJ6,Q9H0H5,Q15005,Q8NBT2,Q96EE3,P25054 7 +T cell proliferation 0.288818279176498 0.1383716580100261 0.8899466951533357 1.0 1.0 22 P30825 1 +Positive regulation of potassium ion transmembrane transporter activity 0.400242238562297 0.1336792010383269 0.89365625269305 1.0 1.0 4 P05026 1 +Regulation of muscle organ development 0.3367274032385818 0.1326032005682261 0.8945072010894122 1.0 1.0 9 P41440,Q8IXJ6 2 +Posttranslational protein targeting to endoplasmic reticulum membrane 0.3363837950821294 0.1311947536286652 0.8956212460854323 1.0 1.0 9 Q99442,P46379,Q9UGP8,O43681 4 +Histone h2b ubiquitination 0.3572116929007456 0.1310091590200801 0.8957680620052355 1.0 1.0 7 O75150,Q8N7H5,Q5VTR2,P50750,Q9NW82,Q6P1J9 6 +Negative regulation of hematopoietic progenitor cell differentiation 0.5227710070558018 0.1305241630911924 0.8961517382846769 1.0 1.0 2 Q92785 1 +Negative regulation of erythrocyte differentiation 0.5227710070557993 0.1305241630911885 0.89615173828468 1.0 1.0 2 Q86U70 1 +Regulation of anaphase promoting complex dependent catabolic process 0.522450288646565 0.130035997485425 0.8965379465966807 1.0 1.0 2 P53350 1 +Anatomical structure maturation 0.2768650974999712 0.1293785704992952 0.8970581034203375 1.0 1.0 31 O75503,Q15645,P09622,Q8IXJ6,P04062,Q14118,Q9NZJ7,Q8N2A8 8 +Positive regulation of oxidative stress induced cell death 0.3963146430476455 0.1247353138294963 0.90073309932685 1.0 1.0 4 P23246,Q07820 2 +Regulation of t cell proliferation 0.303059384114318 0.1236196297498223 0.901616449411756 1.0 1.0 16 P02786,P04439,P30825,Q5ZPR3 4 +Response to wounding 0.2682117368445648 0.1229781885454531 0.9021243698646207 1.0 1.0 77 Q16625,Q04656,Q99623,P10586,Q5JRA6,Q9BWH2,Q9Y3E7,P42785,P00374,P07196,P49257,Q9UQN3,Q11206,P05556,P46108,P30536,Q8WTV0,P09601,Q14118,Q4KMQ2,P38435 21 +Myeloid leukocyte mediated immunity 0.302932147177938 0.1229091776128742 0.9021790180498968 1.0 1.0 16 P09601 1 +Icosanoid metabolic process 0.2954856556539031 0.1215741083924483 0.9032363198650856 1.0 1.0 18 Q9H7Z7,Q8NCG7,P09960,P07099,Q8N8N7,Q8N4Q0,Q15067 7 +Mitotic dna replication checkpoint signaling 0.5166773572803016 0.1214794339203506 0.9033113034083836 1.0 1.0 2 O60921 1 +Muscle cell cellular homeostasis 0.3648829618300004 0.1213783914769848 0.9033913314278296 1.0 1.0 5 P13473 1 +Negative regulation of dendrite morphogenesis 0.5163566388710646 0.1210168185304546 0.903677713839652 1.0 1.0 2 Q9Y4G8 1 +Muscle cell apoptotic process 0.3223519255271463 0.120311906800223 0.9042360723637564 1.0 1.0 11 P09601,O95140 2 +Regulation of bmp signaling pathway 0.3377004024925617 0.1175939066245049 0.9063894332559316 1.0 1.0 8 Q9Y2U8 1 +Actin myosin filament sliding 0.5128287363694602 0.116016034561025 0.9076398338665776 1.0 1.0 2 P09493 1 +Regulation of skeletal muscle tissue development 0.3573142229465929 0.1157570271450612 0.9078451088565892 1.0 1.0 6 P41440 1 +Catechol containing compound metabolic process 0.3529076429473815 0.1154801022262313 0.9080645910786274 1.0 1.0 7 P21964 1 +Transforming growth factor beta production 0.3918485237484002 0.1148679665482596 0.9085497759793192 1.0 1.0 4 P06756,O75787,P08238 3 +Glycolytic process through fructose 6 phosphate 0.3211197813898745 0.11472680419945 0.9086616675255248 1.0 1.0 11 Q9BRR6 1 +Regulation of integrin activation 0.4940648059031104 0.1144657737565522 0.9088685766179564 1.0 1.0 3 O94887,Q15058 2 +Negative regulation by host of viral transcription 0.3915275994865312 0.1141713967450062 0.9091019257078824 1.0 1.0 4 Q9H1E3,P17980,Q13148 3 +Regulation of mda 5 signaling pathway 0.5109044259140401 0.1133560235290582 0.90974830306103 1.0 1.0 2 Q07021 1 +Mda 5 signaling pathway 0.5109044259140401 0.1133560235290582 0.90974830306103 1.0 1.0 2 Q07021 1 +Positive regulation of interleukin 1 production 0.3521887479750966 0.1129208581556207 0.910093299678943 1.0 1.0 7 P49755,P04792,Q99584 3 +Negative regulation of fibroblast apoptotic process 0.5096215522770933 0.111609083360831 0.9111333695454252 1.0 1.0 2 Q9HCK8 1 +Protein transport along microtubule 0.390263047620221 0.1114430000258696 0.911265063314676 1.0 1.0 4 Q14168,P04792 2 +Positive regulation of coagulation 0.4917355711456657 0.1106837110043755 0.9118671633400156 1.0 1.0 3 Q11206 1 +Ventricular system development 0.3609008562701816 0.1105088443346964 0.91200583606685 1.0 1.0 5 Q96N66 1 +Negative regulation of map kinase activity 0.330778265529847 0.1085799210171745 0.9135356872870536 1.0 1.0 9 P04062,P04035 2 +Regulation of alternative mrna splicing via spliceosome 0.2742990632462534 0.1084293473708175 0.9136551225303826 1.0 1.0 31 P62995,Q9Y580,P38159,Q96MU7,Q9Y2W1,Q9BWF3,P98175,Q15007,Q9UHX1,P52756 10 +Regulation of cellular response to transforming growth factor beta stimulus 0.3124683463602264 0.1084102081028933 0.9136703039662976 1.0 1.0 13 Q92896,Q9Y2U8 2 +Regulation of peptidyl threonine phosphorylation 0.3504657886283382 0.1068280337259381 0.9149254070348818 1.0 1.0 7 Q8IXJ6,P53350,P28482,P61086,Q9Y376,Q9C0C2 6 +Negative regulation of microtubule polymerization 0.3543190236863945 0.1063891542833179 0.9152735978679802 1.0 1.0 6 P16949,Q02790,Q15691,P04350 4 +Monocarboxylic acid transport 0.3501445550915498 0.1056984860692163 0.9158215815652552 1.0 1.0 7 O14745,P04083,P53985,P28288,Q6P1M0,O95563 6 +Unsaturated fatty acid biosynthetic process 0.3248170224230787 0.105330615211457 0.9161134706630808 1.0 1.0 10 Q9H7Z7 1 +Posttranslational protein targeting to membrane translocation 0.3872832611740188 0.1051170166045003 0.9162829568118124 1.0 1.0 4 Q99442 1 +Anaphase promoting complex dependent catabolic process 0.3244372990353827 0.1037362391748263 0.9173786670845164 1.0 1.0 10 Q9UJX2,P30260,Q9UJX4,Q16763,P53350,Q9H1A4,Q9UJX3,P24941,Q9UJX5 9 +Regulation of ras protein signal transduction 0.2737061690656109 0.1036232892293719 0.9174683050238186 1.0 1.0 31 P41440,Q5HYI8,Q15555,Q13501,Q8N6T3,P05556,P20936,O95140,P46108,Q96AG4,O75955 11 +Positive regulation of myeloid leukocyte differentiation 0.4870067372473632 0.10321449021294 0.9177927398071206 1.0 1.0 3 Q13546,O00165 2 +Regulation of non canonical wnt signaling pathway 0.5032071840923638 0.1031884823238187 0.9178133808877162 1.0 1.0 2 Q7Z494 1 +Midbrain dopaminergic neuron differentiation 0.5032071840923594 0.1031884823238131 0.9178133808877208 1.0 1.0 2 P35222 1 +Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation 0.5032071840923594 0.1031884823238131 0.9178133808877208 1.0 1.0 2 P35222 1 +Purine containing compound biosynthetic process 0.2653543983990869 0.1005685269766931 0.9198929818370134 1.0 1.0 76 Q9UMR5,P24539,Q8TB61,Q8WVC6,P50897,P00813,Q9UJS0,P00403,P56385,P00846,O75964,Q53GQ0 12 +Regulation of histone h2b ubiquitination 0.356982343499202 0.1001007289861752 0.9202643565935028 1.0 1.0 5 Q9NW82,O75150,Q5VTR2,P50750 4 +Positive regulation of histone ubiquitination 0.3569823434992018 0.1001007289861747 0.9202643565935034 1.0 1.0 5 O60341,O75150,Q5VTR2,P50750 4 +Negative regulation of cytokine production 0.28208415619646 0.0998648472378321 0.920451624637185 1.0 1.0 24 P04062,P09601,P30536 3 +Collagen catabolic process 0.4831864895938293 0.0973844358781928 0.9224211043462228 1.0 1.0 3 Q9UBG0 1 +Regulation of trans synaptic signaling 0.2659447092517341 0.0972508713747833 0.9225271699510916 1.0 1.0 54 P16615,P41440,Q9BPZ3,Q9UJX6,P04899,Q9BVA1,Q13501,Q92542,P05556,Q9P253,Q9UQB8,P55011,Q4J6C6,Q12846,Q14168,Q96A49,O75955 17 +Cell proliferation in forebrain 0.3831361402454113 0.0965547689520758 0.9230799777374415 1.0 1.0 4 Q15154 1 +Endoplasmic reticulum mannose trimming 0.4967928159076255 0.0952840848725169 0.9240891835660512 1.0 1.0 2 O60858 1 +Regulation of peptidase activity 0.2619766189947206 0.0950920940854239 0.9242416776263808 1.0 1.0 73 O14737,Q9NR28,Q96A26,Q9BXI6,P16435,Q96HY6,Q92542,Q9P0J0,O95831,Q9BXK5,Q15392,P51572,P49755,Q15041,Q9NZJ7,Q9NWS0 16 +Regulation of protein localization to plasma membrane 0.2786432412897189 0.0949219767349929 0.9243768004235058 1.0 1.0 27 P98194,O15400,Q13501,P05556,P23634,O15258,Q12846,O00264 8 +Superoxide metabolic process 0.3314851205397802 0.0944658485992049 0.9247391099672988 1.0 1.0 8 Q04656,P00374 2 +Mrna alternative polyadenylation 0.3540930979133261 0.0926114892248084 0.9262122158978414 1.0 1.0 5 Q8N684,Q16630,O43809,Q96MU7 4 +Regulation of cell activation 0.2544152413911084 0.0920127633069866 0.9266878989593884 1.0 1.0 63 O96005,Q9BWH2,Q08722,P30825,P00813,P09601,P11279 7 +Negative regulation of peptidyl lysine acetylation 0.3261878280012663 0.0905830743539187 0.9278238813434396 1.0 1.0 9 Q01105 1 +Negative regulation of translational elongation 0.4903784477228914 0.0878847857704373 0.929968249006914 1.0 1.0 2 P38919 1 +Regulation of phagocytosis 0.304015677036646 0.087781790383624 0.9300501110560276 1.0 1.0 14 Q8WTV0 1 +Response to estrogen 0.311812537040219 0.0875306869639154 0.9302496943617352 1.0 1.0 12 P09601 1 +Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis 0.4900577293136547 0.0875278612610543 0.9302519403263344 1.0 1.0 2 P23396 1 +Chaperone cofactor dependent protein refolding 0.2990189830210129 0.0860305488704871 0.9314421327574016 1.0 1.0 15 P48723 1 +Superoxide anion generation 0.3512038523274517 0.0852807478281324 0.932038196775094 1.0 1.0 5 P04179,P04899,P08754,Q9NY61 4 +Collateral sprouting 0.474409680356006 0.0846763094024365 0.932518730667706 1.0 1.0 3 Q15375 1 +Regulation of collateral sprouting 0.474409680356006 0.0846763094024365 0.932518730667706 1.0 1.0 3 Q15375 1 +Regulation of vesicle mediated transport 0.3009242766444019 0.08351089267081 0.933445316549118 1.0 1.0 116 P41440,P61026,Q9P2W9,P11279,Q15907,P18031,P31751,P16615,P98194,Q9UHD9,P61978,P50897,Q9Y3E7,Q9NR31,Q9H4M9,Q8IZ07,Q12907,Q4J6C6,Q12846,P04899,Q08722,Q8N6T3,O00560,Q9H223,Q6NUQ1,P53367,P61020,Q92783,Q8WTV0,P27361,Q9P253,P09601,P57105,Q4KMQ2,O75955 35 +Negative regulation of guanyl nucleotide exchange factor activity 0.4728905999358367 0.0825731732415546 0.934190933061589 1.0 1.0 3 P16949,Q9NWH9 2 +Macrophage migration 0.3499197431781747 0.0820738316248889 0.934588002241244 1.0 1.0 5 P17931,P27361,Q9BW27,P28482 4 +Macrophage chemotaxis 0.3499197431781747 0.0820738316248889 0.934588002241244 1.0 1.0 5 P17931,P27361,Q9BW27,P28482 4 +Positive regulation of fibroblast proliferation 0.3499197431781736 0.0820738316248861 0.9345880022412464 1.0 1.0 5 Q08211,P14635,P11802,Q7Z5K2 4 +Positive regulation of glucose transmembrane transport 0.3437511800798647 0.0747392520426463 0.9404221763804156 1.0 1.0 6 Q16625 1 +Positive regulation of protein dephosphorylation 0.3086209164338442 0.0731205899687963 0.9417101570891124 1.0 1.0 12 Q86XL3 1 +Negative regulation of activated t cell proliferation 0.4749839640795309 0.0721097812297118 0.9425145421963528 1.0 1.0 2 P10644 1 +Apoptotic process involved in morphogenesis 0.47498396407953 0.072109781229711 0.9425145421963534 1.0 1.0 2 P30154 1 +Viral budding 0.3114183313409068 0.0720586345443273 0.942555245459676 1.0 1.0 11 Q9Y3E7,Q9H9H4,Q9UQN3 3 +Eye morphogenesis 0.3112077232041006 0.0711589371751581 0.9432712619192968 1.0 1.0 11 P54802 1 +Positive regulation of neuroblast proliferation 0.4733803720333465 0.0706217601575308 0.9436987915495796 1.0 1.0 2 P35222 1 +Humoral immune response 0.3080368804158143 0.0705132706070312 0.9437851384250392 1.0 1.0 12 P35232,Q99623,Q9UQ84 3 +Negative regulation of p38mapk cascade 0.4720974983964027 0.0694517631030932 0.9446300273547634 1.0 1.0 2 Q12959 1 +Negative regulation of sister chromatid cohesion 0.471776779987163 0.0691620828908588 0.9448606042750172 1.0 1.0 2 Q7Z5K2 1 +Positive regulation of immune response 0.2597239919102871 0.0685429856815129 0.9453534028884868 1.0 1.0 73 O15400,Q99623,P11279,P35232,P23246,Q96FZ2,O96028,Q9NUD5,Q12846,P04439,Q08722,P00813,Q07021,P12956,P01889,P51809,P43243,Q15233,Q07666,Q9UJZ1,P46379,Q8WXF1,Q5ZPR3,P02786,Q9NUQ9 25 +Regulation of membrane permeability 0.2863540273791134 0.068195058236205 0.945630360771653 1.0 1.0 18 P45880 1 +Positive regulation of exocytosis 0.2949933753533466 0.0653680986776523 0.9478809233041758 1.0 1.0 15 P51809,Q92783,O14964,O00560,P11279,Q12846,P51149 7 +Mrna splice site selection 0.2778075387063127 0.0649597328171412 0.9482060610617598 1.0 1.0 20 Q13242,Q9UHX1 2 +Negative regulation of cell growth involved in cardiac muscle cell development 0.458774462624313 0.0643675356389093 0.9486775792095312 1.0 1.0 3 P49840,O94826 2 +Negative regulation of cardiac muscle tissue growth 0.458774462624313 0.0643675356389093 0.9486775792095312 1.0 1.0 3 P49840,O94826 2 +Multicellular organismal response to stress 0.3400770712909366 0.064260634941585 0.9487626974059988 1.0 1.0 6 P51608,Q04637,P30536,P06730,P42345 5 +Myeloid cell activation involved in immune response 0.314551497454264 0.0634535538023096 0.9494053433644276 1.0 1.0 10 P51809,P09601,Q12846,Q9UNH7 4 +Regulation of camp mediated signaling 0.4644002565747189 0.0628052635558858 0.9499215744347832 1.0 1.0 2 Q9Y4G8 1 +Negative regulation of histone acetylation 0.3361450829557244 0.0584980173839582 0.9533519416906144 1.0 1.0 7 Q01105 1 +Regulation of endocytosis 0.2666827186251005 0.0568318475276814 0.9546791442694356 1.0 1.0 47 P41440,Q9UHD9,P61978,P50897,Q8N6T3,O00560,Q9H223,Q8IZ07,P57105,Q4KMQ2,P18031,O75955 12 +Receptor catabolic process 0.3393249855935403 0.0568298979516137 0.9546806972961116 1.0 1.0 5 Q9Y371 1 +Positive regulation of dephosphorylation 0.3013174005061465 0.0557378217400628 0.9555506689297008 1.0 1.0 13 Q86XL3 1 +Ventral spinal cord development 0.4510747513634976 0.0554349602771802 0.9557919443739038 1.0 1.0 3 Q6Y7W6,Q14203 2 +Regulation of striated muscle contraction 0.3011816239439609 0.0551179989147852 0.9560444568808232 1.0 1.0 13 P16615 1 +Hemostasis 0.2747635197995605 0.054337161025759 0.95666654305563 1.0 1.0 25 Q11206,Q9BWH2 2 +Positive regulation of protein k63 linked ubiquitination 0.4522129570237315 0.0535345012003292 0.9573060420690228 1.0 1.0 2 P61088 1 +Positive regulation of chemokine c c motif ligand 5 production 0.4522129570237309 0.053534501200329 0.9573060420690233 1.0 1.0 2 Q7Z434 1 +Positive regulation of nlrp3 inflammasome complex assembly 0.4522129570237252 0.0535345012003248 0.9573060420690264 1.0 1.0 2 Q9H6R0 1 +Negative regulation of glucose transmembrane transport 0.4518922386144907 0.0533103439057274 0.957484638677919 1.0 1.0 2 P49840 1 +Negative regulation of glucose import 0.4518922386144907 0.0533103439057274 0.957484638677919 1.0 1.0 2 P49840 1 +Negative regulation of calcium ion dependent exocytosis 0.451892238614488 0.0533103439057257 0.9574846386779204 1.0 1.0 2 P04899 1 +Process utilizing autophagic mechanism 0.3404378641125428 0.0532902022678575 0.9575006865682276 1.0 1.0 167 Q9Y487,Q9Y679,Q96GC9,O15118,Q9H300,Q9NZ45,P04062,Q99623,O15269,P21796,P16615,Q709C8,Q9BWH2,Q9UHD9,Q96HY6,Q13501,Q9Y3E7,Q13099,Q969Q5,Q9UQN3,O43464,P12235,Q9H0U4,Q86UE4,P52789,Q8IXJ6,Q86Y82,Q9HD42,O00459,O95721,P30536,Q9H9H4,Q9NZJ7,Q93050,P05141,Q07820,O75844,P10619,Q8TBX8,P20073,Q92783,P27361,P13473,Q9NRR5,Q9Y5X3,Q9Y371,Q9P253,P09601,O95140,O75396,Q9Y6I9 51 +Erbb2 signaling pathway 0.4485081809432202 0.0526100355286666 0.9580426208503504 1.0 1.0 3 O75131,Q93034 2 +Medium chain fatty acyl coa metabolic process 0.4465832531280122 0.0505406812607409 0.9596915318525598 1.0 1.0 3 A8MXV4,P51659 2 +Fatty acyl coa catabolic process 0.4464400256574671 0.0496483680888326 0.9604026019707872 1.0 1.0 2 A8MXV4 1 +Regulation of reproductive process 0.2893020234855695 0.0495950887168855 0.9604450604537772 1.0 1.0 16 Q15645,P00813 2 +Response to l phenylalanine derivative 0.4443375040102754 0.0481794182358523 0.9615732530043029 1.0 1.0 3 O94826,Q96SB3 2 +Positive regulation of mitochondrial fission 0.3147689763177909 0.0479678365919561 0.9617418757685674 1.0 1.0 9 Q9GZY8 1 +Actin filament based movement 0.2695166742898617 0.0460808836919601 0.9632457824247908 1.0 1.0 29 P16615,Q9UM22 2 +Positive regulation of rho protein signal transduction 0.4358563181526586 0.0433074698090263 0.9654564367641304 1.0 1.0 2 Q9Y624 1 +Fibroblast migration 0.2983933253054906 0.0425088703805278 0.9660930406024912 1.0 1.0 13 O95470 1 +Hindbrain development 0.2658297214816156 0.042037306546817 0.9664689580663728 1.0 1.0 36 Q9BRK5,Q92542,Q04656,P05556,P04062,P46108,P54802,O14949 8 +Regulation of ion transmembrane transport 0.2541788616379797 0.0417558026910542 0.9666933686032 1.0 1.0 60 Q8N668,P05026,P08183,P0CG08,Q9BVC6,Q4KMQ2,Q96GC9,Q04656,P05556,O00483,P23634,Q99623,Q8TAD4,P54709,Q15041,P21796,O75844,O75915 18 +Positive regulation of programmed necrotic cell death 0.4379210779595706 0.0417427690495906 0.966703758885402 1.0 1.0 3 Q9NZI8,Q13546 2 +Glutamine transport 0.4323284156510523 0.0414068299356167 0.9669715679673394 1.0 1.0 2 Q15758 1 +Regulation of superoxide anion generation 0.3510911424903736 0.0399179671603594 0.9681585267965432 1.0 1.0 4 P04899,Q9NY61,P08754 3 +Exocytic process 0.2873289503364697 0.0394689850825023 0.9685164805594636 1.0 1.0 16 O95721,P61026,Q9P253 3 +Meiotic cell cycle checkpoint signaling 0.3502605399151582 0.0386723345071547 0.9691516307684273 1.0 1.0 4 Q15645,O60921 2 +Epithelial to mesenchymal transition 0.2723304385907072 0.0378927094018538 0.9697732259306464 1.0 1.0 25 Q99729,Q9UBV8,Q9NQC3,O00560,Q14118 5 +Nls bearing protein import into nucleus 0.3119158738195985 0.0378198051272347 0.9698313534596716 1.0 1.0 9 Q8NFH5,P52292 2 +Blastocyst development 0.2646072956029249 0.0377677297419571 0.9698728739417046 1.0 1.0 34 Q9NQC3 1 +Establishment of protein localization to organelle 0.3524521116890379 0.0364152992480863 0.9709512152345744 1.0 1.0 185 Q8N4H5,O75381,P61026,Q9H300,Q9NS69,Q9P0J0,Q99623,Q3ZCQ8,P11279,O43615,O60830,Q14108,Q53H12,Q9UNL2,Q99442,Q7Z3B4,P40855,P02545,Q10713,Q15629,O14925,Q8N1F7,Q9NWS0,Q9Y512,P52789,Q8NFH5,O00459,Q15070,Q9GZY8,Q9Y5M8,O95831,O43765,P55786,P51572,P30536,Q9BZL1,Q9H9H4,Q9Y5J9,P20645,Q9UGP8,Q15388,O14737,P13473,O43681,Q9Y371,Q9Y276,Q15005,P46379,O95140,O96008,Q5JRX3,P52292 52 +Ribose phosphate biosynthetic process 0.2655618374718824 0.0357350866715627 0.971493593291442 1.0 1.0 82 Q9UMR5,P24539,Q8WVC6,Q8TB61,P50897,P00813,Q02127,Q9UJS0,P00403,P56385,P00846,O75964,Q53GQ0 13 +Regulation of high voltage gated calcium channel activity 0.4188582424631079 0.0350490926750987 0.972040594605076 1.0 1.0 2 O75323 1 +Regulation of meiotic cell cycle 0.328918628380584 0.0341698372159058 0.9727417189040046 1.0 1.0 5 Q15645 1 +Positive regulation of regulated secretory pathway 0.3285852321591433 0.0334790829786595 0.973292545845198 1.0 1.0 5 P11279 1 +Regulation of epidermal growth factor activated receptor activity 0.4254090471607283 0.0304690148689296 0.9756930044552958 1.0 1.0 3 Q99816,Q9UNH7 2 +Negative regulation of epidermal growth factor activated receptor activity 0.4254090471607283 0.0304690148689296 0.9756930044552958 1.0 1.0 3 Q99816,Q9UNH7 2 +N acetylglucosamine metabolic process 0.4060295060936479 0.0301905519070208 0.9759150835843222 1.0 1.0 2 O60502 1 +Dense core granule transport 0.4047466324567013 0.0297625634150412 0.9762564155977618 1.0 1.0 2 P33176 1 +Anterograde neuronal dense core vesicle transport 0.4047466324567013 0.0297625634150412 0.9762564155977618 1.0 1.0 2 P33176 1 +Magnesium ion homeostasis 0.4233677572059637 0.0287843538854245 0.9770365795009316 1.0 1.0 3 Q6P4Q7 1 +Regulation of sodium ion transport 0.2755350914897056 0.0276343540819616 0.977953781526057 1.0 1.0 19 Q8N668,P23634,P05023,P05026 4 +Regulation of intracellular lipid transport 0.3973701090442565 0.0274887225323935 0.9780699345653872 1.0 1.0 2 P22307 1 +Positive regulation of intracellular lipid transport 0.3973701090442565 0.0274887225323935 0.9780699345653872 1.0 1.0 2 P22307 1 +Positive regulation of mrna processing 0.2711226785813819 0.0247243976860883 0.9802747944876068 1.0 1.0 20 Q13595,Q14011,P98179,P38159 4 +Arf protein signal transduction 0.4181582826966915 0.0246743276501052 0.9803147324121788 1.0 1.0 3 Q8N6T3 1 +Negative regulation of establishment of protein localization to mitochondrion 0.3806927517639454 0.0234008783585938 0.9813305043700828 1.0 1.0 2 P49257 1 +Mesenchymal to epithelial transition 0.415463586782177 0.022652922438838 0.981927128639272 1.0 1.0 3 P80723,P35222 2 +Metanephros morphogenesis 0.415463586782177 0.022652922438838 0.981927128639272 1.0 1.0 3 P80723,P35222 2 +Foam cell differentiation 0.4154635867821643 0.0226529224388285 0.9819271286392794 1.0 1.0 3 P06756,P35610 2 +Suppression of viral release by host 0.3243416827231781 0.022559174254316 0.982001909758011 1.0 1.0 6 P19474,Q9Y3E7,O60858,Q12899,Q14258 5 +Positive regulation of bone mineralization 0.4153228814010428 0.0225492987585789 0.9820097872597178 1.0 1.0 3 P20020 1 +Positive regulation of biomineralization 0.4153228814010428 0.0225492987585789 0.9820097872597178 1.0 1.0 3 P20020 1 +Paranodal junction assembly 0.3717126363053186 0.0217172252977856 0.9826735232125718 1.0 1.0 2 Q9Y2J2 1 +Regulation of hematopoietic stem cell proliferation 0.3713919178960843 0.0216629514973101 0.982716817254768 1.0 1.0 2 O95251 1 +Dendritic cell differentiation 0.3379332477535377 0.0214697036359881 0.9828709708863896 1.0 1.0 4 P17931,P01889,P09429 3 +Ventricular septum morphogenesis 0.3379332477535328 0.021469703635982 0.9828709708863944 1.0 1.0 4 O94813,O96028,Q96T37 3 +Cardiac muscle cell proliferation 0.3379332477535322 0.0214697036359814 0.982870970886395 1.0 1.0 4 Q16539,P06493,P10644 3 +Negative regulation of low density lipoprotein particle clearance 0.3636946760744041 0.0204708518777628 0.983667764034521 1.0 1.0 2 Q92945 1 +Positive regulation of establishment of protein localization to mitochondrion 0.289866537014999 0.0203671942406083 0.983750453622828 1.0 1.0 14 O43464,O14737,Q9Y371,P49840,P55786,Q9BZL1 6 +Adiponectin activated signaling pathway 0.3624118024374572 0.0202917396962934 0.983810645199275 1.0 1.0 2 P33121 1 +Positive regulation of synaptic vesicle endocytosis 0.353110968569593 0.0191435273298943 0.984726607995003 1.0 1.0 2 O14656 1 +Antibacterial humoral response 0.3524695317511182 0.0190734410509047 0.9847825185465632 1.0 1.0 2 P04439 1 +Regulation of platelet aggregation 0.3508659397049353 0.0189030040449975 0.9849184830886076 1.0 1.0 2 Q9Y624 1 +Positive regulation of fatty acid transport 0.3495830660679885 0.0187714609050571 0.985023420709216 1.0 1.0 2 P33121 1 +Udp glucose metabolic process 0.4096888033365408 0.0185541007492845 0.9851968188214416 1.0 1.0 3 P49840,Q9NYU2 2 +Negative regulation of receptor signaling pathway via jak stat 0.347338037203331 0.0185512082078264 0.9851991263384536 1.0 1.0 2 O14964 1 +Meiosis ii cell cycle process 0.3473380372033324 0.0185512082078264 0.9851991263384536 1.0 1.0 2 O60566 1 +Negative regulation of receptor signaling pathway via stat 0.347338037203331 0.0185512082078264 0.9851991263384536 1.0 1.0 2 O14964 1 +Meiotic sister chromatid cohesion centromeric 0.3473380372033324 0.0185512082078264 0.9851991263384536 1.0 1.0 2 O60566 1 +Negative regulation of viral entry into host cell 0.4090471607314718 0.018117890966849 0.9855448053663828 1.0 1.0 3 Q14258,O60493 2 +Negative regulation of viral life cycle 0.4090471607314718 0.018117890966849 0.9855448053663828 1.0 1.0 3 Q14258,O60493 2 +Cardiac left ventricle morphogenesis 0.3377164849262316 0.01773891901685 0.98584713264037 1.0 1.0 2 P49840 1 +Aorta morphogenesis 0.3377164849262314 0.01773891901685 0.98584713264037 1.0 1.0 2 Q96AY3 1 +Skeletal muscle tissue regeneration 0.3203965008557826 0.017200395162066 0.9862767469427712 1.0 1.0 5 Q14118 1 +Anatomical structure arrangement 0.3062860808210351 0.0161958063258773 0.98707818109307 1.0 1.0 2 Q15058 1 +Secretory granule localization 0.4048764837985242 0.0153738543178888 0.987733922193908 1.0 1.0 3 O60763,P33176 2 +Negative regulation of rig i signaling pathway 0.4042348411934554 0.0149655563562279 0.9880596593499952 1.0 1.0 3 Q92890,Q07021 2 +Negative regulation of organ growth 0.3308729139922996 0.0126777702900795 0.9898848737812588 1.0 1.0 4 P49840,P11413,O94826 3 +Multivesicular body organization 0.2841399962024317 0.0122184611745786 0.9902513210373076 1.0 1.0 15 Q92783,Q9Y3E7,Q9H9H4,Q9UQN3 4 +Positive regulation of cell cell adhesion 0.2635505632663771 0.0120518518133474 0.9903842462863846 1.0 1.0 30 P00813,P30825,Q11206 3 +Cell fate specification 0.3068766066838124 0.0115982502173856 0.9907461426902526 1.0 1.0 8 Q9UJX6,P05556,Q14318,Q06330,P35222,Q96KQ7,P25054 7 +Negative regulation of dna binding transcription factor activity 0.2669321392147984 0.0115792759878365 0.9907612809185008 1.0 1.0 27 Q99623,O76024,O75381,P09601 4 +Ether metabolic process 0.3207657331775637 0.0114640013141789 0.9908532506962012 1.0 1.0 7 P07099 1 +Polysaccharide metabolic process 0.2725928378441528 0.011130062651935 0.9911196781961512 1.0 1.0 19 Q7LGA3 1 +Positive regulation of mitochondrial membrane potential 0.3952908056872788 0.0096456062367978 0.9923040390400366 1.0 1.0 3 P31751 1 +Regulation of dna templated transcription in response to stress 0.295978632778435 0.0093054401141807 0.9925754401518514 1.0 1.0 11 P09601 1 +Activation of immune response 0.2615660286945664 0.009131454762727 0.9927142544790768 1.0 1.0 47 Q99623,P35232,P23246,Q9UI10,Q9NUD5,P17931,P04439,Q08722,P00813,Q7Z434,Q07021,P12956,P43243,Q15233,Q07666,P46379,Q96PK6,Q8WXF1,Q5ZPR3,Q9UJZ1 20 +Embryonic organ morphogenesis 0.2686746583584184 0.0089341306514512 0.9928716899178668 1.0 1.0 21 P54802 1 +Response to hepatocyte growth factor 0.3157720334355096 0.0085896448605202 0.9931465392601202 1.0 1.0 5 Q8IXJ6 1 +Positive regulation of mitophagy in response to mitochondrial depolarization 0.3269554450205857 0.0081228973089647 0.9935189369199364 1.0 1.0 4 Q709C8,O95140 2 +Membrane to membrane docking 0.388835418671807 0.0062180472761892 0.995038748050407 1.0 1.0 3 Q13464,P15311 2 +Immunological synapse formation 0.3888354186718026 0.0062180472761869 0.9950387480504088 1.0 1.0 3 P17931,Q12959 2 +Mitotic spindle midzone assembly 0.324775353016693 0.0056860615723137 0.9954632037064404 1.0 1.0 4 O43663,Q9H0H5,Q02241 3 +Negative regulation of single stranded viral rna replication via double stranded dna intermediate 0.3241335044929471 0.004981825569872 0.9960250947351144 1.0 1.0 4 Q15047,Q9Y6X9,Q9UK61 3 +Extrinsic apoptotic signaling pathway via death domain receptors 0.2823026018751506 0.0036101882140909 0.9971194928195476 1.0 1.0 15 P09601 1 +Response to corticosteroid 0.266217594920864 0.0014685054499948 0.9988283025951236 1.0 1.0 26 P16435,O95831,P04062,P16278,P07196 5 +Abscission 0.3763233878729575 0.0004800482169816 0.9996169769539404 1.0 1.0 3 P53990,Q8N0X7 2 +Regulation of translation in response to stress 0.293663515933413 0.0004797929356254 0.9996171806389698 1.0 1.0 11 Q15363 1 diff --git a/msigdb_gobp/selections.json b/msigdb_gobp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..9b4e56add0e511526f073771440bcb7a2122998b --- /dev/null +++ b/msigdb_gobp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["10 formyltetrahydrofolate metabolic process", "2 oxoglutarate metabolic process", "2fe 2s cluster assembly", "3 phosphoadenosine 5 phosphosulfate biosynthetic process", "3 phosphoadenosine 5 phosphosulfate metabolic process", "3 utr mediated mrna destabilization", "3 utr mediated mrna stabilization", "5 phosphoribose 1 diphosphate metabolic process", "5s class rrna transcription by rna polymerase iii", "Abscission", "Acetyl coa biosynthetic process", "Acetyl coa biosynthetic process from pyruvate", "Acetyl coa metabolic process", "Acid secretion", "Acidic amino acid transport", "Acrosome assembly", "Actin crosslink formation", "Actin cytoskeleton reorganization", "Actin filament based movement", "Actin filament based process", "Actin filament based transport", "Actin filament bundle organization", "Actin filament depolymerization", "Actin filament network formation", "Actin filament organization", "Actin filament polymerization", "Actin filament reorganization", "Actin filament severing", "Actin mediated cell contraction", "Actin modification", "Actin myosin filament sliding", "Actin nucleation", "Actin polymerization dependent cell motility", "Actin polymerization or depolymerization", "Action potential", "Activated t cell proliferation", "Activation induced cell death of t cells", "Activation of adenylate cyclase activity", "Activation of cysteine type endopeptidase activity", "Activation of cysteine type endopeptidase activity involved in apoptotic process", "Activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome c", "Activation of gtpase activity", "Activation of immune response", "Activation of innate immune response", "Activation of nf kappab inducing kinase activity", "Activation of phospholipase c activity", "Activation of phospholipase d activity", "Activation of protein kinase activity", "Activation of protein kinase b activity", "Activation of protein kinase c activity", "Activin receptor signaling pathway", "Actomyosin contractile ring organization", "Actomyosin structure organization", "Acute inflammatory response", "Acute inflammatory response to antigenic stimulus", "Acute phase response", "Acyl carnitine transmembrane transport", "Acylglycerol homeostasis", "Adaptation of signaling pathway", "Adaptive immune response", "Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", "Adaptive thermogenesis", "Adenosine metabolic process", "Adenosine to inosine editing", "Adenylate cyclase activating adrenergic receptor signaling pathway", "Adenylate cyclase activating adrenergic receptor signaling pathway involved in heart process", "Adenylate cyclase activating dopamine receptor signaling pathway", "Adenylate cyclase activating g protein coupled receptor signaling pathway", "Adenylate cyclase inhibiting dopamine receptor signaling pathway", "Adenylate cyclase inhibiting g protein coupled receptor signaling pathway", "Adenylate cyclase modulating g protein coupled receptor signaling pathway", "Adherens junction assembly", "Adherens junction maintenance", "Adherens junction organization", "Adhesion of symbiont to host", "Adhesion of symbiont to host cell", "Adiponectin activated signaling pathway", "Adipose tissue development", "Adp biosynthetic process", "Adp metabolic process", "Adp transport", "Adrenal gland development", "Adrenergic receptor signaling pathway", "Adult behavior", "Adult locomotory behavior", "Aerobic respiration", "Aggrephagy", "Aggresome assembly", "Aging", "Alanine catabolic process", "Alanine transport", "Alcohol biosynthetic process", "Alcohol catabolic process", "Alcohol metabolic process", "Aldehyde biosynthetic process", "Aldehyde catabolic process", "Alditol biosynthetic process", "Alditol catabolic process", "Alditol metabolic process", "Alditol phosphate metabolic process", "Alkanesulfonate metabolic process", "Allantoin metabolic process", "Alpha amino acid catabolic process", "Alpha amino acid metabolic process", "Alpha beta t cell activation", "Alpha beta t cell differentiation", "Alpha beta t cell proliferation", "Alpha ketoglutarate transport", "Alpha linolenic acid metabolic process", "Alternative mrna splicing via spliceosome", "Ameboidal type cell migration", "Amelogenesis", "Amide biosynthetic process", "Amide transport", "Amine biosynthetic process", "Amine catabolic process", "Amine metabolic process", "Amine transport", "Amino acid activation", "Amino acid betaine biosynthetic process", "Amino acid betaine metabolic process", "Amino acid betaine transport", "Amino acid homeostasis", "Amino acid import", "Amino acid import across plasma membrane", "Amino acid neurotransmitter reuptake", "Amino acid salvage", "Amino acid transmembrane transport", "Amino acid transport", "Amino sugar biosynthetic process", "Amino sugar catabolic process", "Amino sugar metabolic process", "Aminoacyl trna metabolism involved in translational fidelity", "Aminoglycan biosynthetic process", "Aminoglycan catabolic process", "Aminoglycan metabolic process", "Aminoglycoside antibiotic metabolic process", "Aminophospholipid transport", "Ammonium ion metabolic process", "Ammonium transmembrane transport", "Amp biosynthetic process", "Amp catabolic process", "Amp metabolic process", "Amp salvage", "Ampa glutamate receptor clustering", "Amygdala development", "Amyloid beta clearance", "Amyloid beta clearance by cellular catabolic process", "Amyloid beta clearance by transcytosis", "Amyloid beta formation", "Amyloid beta metabolic process", "Amyloid fibril formation", "Amyloid precursor protein biosynthetic process", "Amyloid precursor protein catabolic process", "Amyloid precursor protein metabolic process", "Anagen", "Anaphase promoting complex dependent catabolic process", "Anatomical structure arrangement", "Anatomical structure formation involved in morphogenesis", "Anatomical structure homeostasis", "Anatomical structure maturation", "Androgen biosynthetic process", "Androgen catabolic process", "Androgen metabolic process", "Androgen receptor signaling pathway", "Angiogenesis involved in coronary vascular morphogenesis", "Angiogenesis involved in wound healing", "Angiotensin activated signaling pathway", "Animal organ formation", "Animal organ maturation", "Animal organ morphogenesis", "Animal organ regeneration", "Anion homeostasis", "Anion transmembrane transport", "Anion transport", "Anoikis", "Anterior head development", "Anterior posterior axis specification", "Anterior posterior pattern specification", "Anterograde axonal transport", "Anterograde axonal transport of mitochondrion", "Anterograde dendritic transport", "Anterograde dendritic transport of neurotransmitter receptor complex", "Anterograde neuronal dense core vesicle transport", "Antibacterial humoral response", "Antifungal innate immune response", "Antigen processing and presentation", "Antigen processing and presentation of endogenous antigen", "Antigen processing and presentation of endogenous peptide antigen", "Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway", "Antigen processing and presentation of exogenous antigen", "Antigen processing and presentation of exogenous peptide antigen", "Antigen processing and presentation of exogenous peptide antigen via mhc class i", "Antigen processing and presentation of exogenous peptide antigen via mhc class ii", "Antigen processing and presentation of lipid antigen via mhc class ib", "Antigen processing and presentation of peptide antigen", "Antigen processing and presentation of peptide antigen via mhc class i", "Antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii", "Antigen processing and presentation via mhc class ib", "Antigen receptor mediated signaling pathway", "Antimicrobial humoral immune response mediated by antimicrobial peptide", "Antimicrobial humoral response", "Antiviral innate immune response", "Aorta development", "Aorta morphogenesis", "Aortic valve morphogenesis", "Apical junction assembly", "Apical protein localization", "Apolipoprotein a i mediated signaling pathway", "Apoptotic cell clearance", "Apoptotic chromosome condensation", "Apoptotic dna fragmentation", "Apoptotic mitochondrial changes", "Apoptotic process involved in development", "Apoptotic process involved in morphogenesis", "Apoptotic signaling pathway", "Appendage development", "Appendage morphogenesis", "Arachidonic acid metabolic process", "Arachidonic acid secretion", "Arf protein signal transduction", "Arginine catabolic process", "Arginine metabolic process", "Aromatic amino acid family catabolic process", "Aromatic amino acid family metabolic process", "Aromatic amino acid transport", "Arp2 3 complex mediated actin nucleation", "Arterial endothelial cell differentiation", "Artery development", "Artery morphogenesis", "Asparagine metabolic process", "Aspartate family amino acid biosynthetic process", "Aspartate family amino acid catabolic process", "Aspartate family amino acid metabolic process", "Aspartate metabolic process", "Aspartate transmembrane transport", "Associative learning", "Astral microtubule organization", "Astrocyte cell migration", "Astrocyte development", "Astrocyte differentiation", "Asymmetric cell division", "Asymmetric neuroblast division", "Atf6 mediated unfolded protein response", "Atp biosynthetic process", "Atp metabolic process", "Atp synthesis coupled electron transport", "Atp synthesis coupled proton transport", "Atp transport", "Atrial cardiac muscle cell membrane repolarization", "Atrial cardiac muscle cell to av node cell signaling", "Atrial septum development", "Atrial septum morphogenesis", "Atrioventricular canal development", "Attachment of gpi anchor to protein", "Attachment of mitotic spindle microtubules to kinetochore", "Attachment of spindle microtubules to kinetochore", "Auditory receptor cell development", "Auditory receptor cell morphogenesis", "Autonomic nervous system development", "Autophagic cell death", "Autophagosome lysosome fusion", "Autophagosome maturation", "Autophagosome membrane docking", "Autophagosome organization", "Autophagy of mitochondrion", "Autophagy of nucleus", "Av node cell to bundle of his cell communication", "Av node cell to bundle of his cell signaling", "Axial mesoderm development", "Axis elongation", "Axis specification", "Axo dendritic protein transport", "Axo dendritic transport", "Axon development", "Axon ensheathment in central nervous system", "Axon extension", "Axonal fasciculation", "Axonal transport", "Axonal transport of mitochondrion", "Axonemal dynein complex assembly", "Axoneme assembly", "Axonogenesis involved in innervation", "Azole transmembrane transport", "B cell activation", "B cell activation involved in immune response", "B cell apoptotic process", "B cell differentiation", "B cell homeostasis", "B cell lineage commitment", "B cell mediated immunity", "B cell proliferation", "B cell receptor signaling pathway", "Barbed end actin filament capping", "Base conversion or substitution editing", "Base excision repair", "Base excision repair ap site formation", "Base excision repair gap filling", "Basement membrane assembly", "Basement membrane organization", "Basic amino acid transport", "Behavior", "Behavioral response to cocaine", "Behavioral response to ethanol", "Behavioral response to pain", "Benzene containing compound metabolic process", "Bergmann glial cell differentiation", "Bicarbonate transport", "Bile acid and bile salt transport", "Bile acid biosynthetic process", "Bile acid metabolic process", "Bile acid secretion", "Binding of sperm to zona pellucida", "Biological adhesion", "Biological phase", "Biological process involved in interaction with host", "Biological process involved in interaction with symbiont", "Biological process involved in interspecies interaction between organisms", "Biological process involved in intraspecies interaction between organisms", "Biological process involved in symbiotic interaction", "Biomineralization", "Blastocyst development", "Blastocyst formation", "Blastocyst growth", "Blastoderm segmentation", "Bleb assembly", "Blood vessel endothelial cell differentiation", "Blood vessel endothelial cell migration", "Blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Blood vessel morphogenesis", "Blood vessel remodeling", "Body fluid secretion", "Body morphogenesis", "Bone cell development", "Bone development", "Bone growth", "Bone marrow development", "Bone maturation", "Bone mineralization", "Bone morphogenesis", "Bone remodeling", "Bone resorption", "Box c d snornp assembly", "Bradykinin catabolic process", "Brain derived neurotrophic factor receptor signaling pathway", "Brain morphogenesis", "Brainstem development", "Branch elongation of an epithelium", "Branched chain amino acid biosynthetic process", "Branched chain amino acid catabolic process", "Branched chain amino acid metabolic process", "Branched chain amino acid transport", "Branching involved in blood vessel morphogenesis", "Branching involved in labyrinthine layer morphogenesis", "Branching involved in mammary gland duct morphogenesis", "Branching involved in salivary gland morphogenesis", "Branching morphogenesis of a nerve", "Branching morphogenesis of an epithelial tube", "Branchiomotor neuron axon guidance", "Brown fat cell differentiation", "Bundle of his cell to purkinje myocyte communication", "C 5 methylation of cytosine", "C terminal protein amino acid modification", "C terminal protein lipidation", "C21 steroid hormone biosynthetic process", "C21 steroid hormone metabolic process", "C4 dicarboxylate transport", "Cadmium ion transmembrane transport", "Calcineurin mediated signaling", "Calcium activated phospholipid scrambling", "Calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules", "Calcium import into the mitochondrion", "Calcium ion export", "Calcium ion export across plasma membrane", "Calcium ion import", "Calcium ion import into cytosol", "Calcium ion import into sarcoplasmic reticulum", "Calcium ion regulated exocytosis", "Calcium ion regulated exocytosis of neurotransmitter", "Calcium ion transmembrane transport", "Calcium ion transmembrane transport via high voltage gated calcium channel", "Calcium ion transport", "Calcium ion transport into cytosol", "Calcium mediated signaling", "Calcium mediated signaling using intracellular calcium source", "Calmodulin dependent kinase signaling pathway", "Camera type eye development", "Camera type eye morphogenesis", "Camera type eye photoreceptor cell differentiation", "Camp mediated signaling", "Cannabinoid signaling pathway", "Canonical wnt signaling pathway", "Canonical wnt signaling pathway involved in cardiac muscle cell fate commitment", "Canonical wnt signaling pathway involved in heart development", "Canonical wnt signaling pathway involved in osteoblast differentiation", "Canonical wnt signaling pathway involved in regulation of cell proliferation", "Cap dependent translational initiation", "Carbohydrate biosynthetic process", "Carbohydrate catabolic process", "Carbohydrate derivative biosynthetic process", "Carbohydrate derivative catabolic process", "Carbohydrate derivative metabolic process", "Carbohydrate derivative transport", "Carbohydrate homeostasis", "Carbohydrate import across plasma membrane", "Carbohydrate mediated signaling", "Carbohydrate metabolic process", "Carbohydrate phosphorylation", "Carbohydrate transmembrane transport", "Carbohydrate transport", "Carboxylic acid transport", "Cardiac atrium development", "Cardiac atrium morphogenesis", "Cardiac cell development", "Cardiac cell fate commitment", "Cardiac chamber development", "Cardiac chamber morphogenesis", "Cardiac conduction", "Cardiac conduction system development", "Cardiac epithelial to mesenchymal transition", "Cardiac left ventricle morphogenesis", "Cardiac muscle cell action potential", "Cardiac muscle cell action potential involved in contraction", "Cardiac muscle cell cardiac muscle cell adhesion", "Cardiac muscle cell contraction", "Cardiac muscle cell differentiation", "Cardiac muscle cell fate commitment", "Cardiac muscle cell membrane repolarization", "Cardiac muscle cell myoblast differentiation", "Cardiac muscle cell proliferation", "Cardiac muscle contraction", "Cardiac muscle tissue development", "Cardiac muscle tissue morphogenesis", "Cardiac neural crest cell development involved in outflow tract morphogenesis", "Cardiac neural crest cell differentiation involved in heart development", "Cardiac neural crest cell migration involved in outflow tract morphogenesis", "Cardiac septum development", "Cardiac septum morphogenesis", "Cardiac ventricle development", "Cardiac ventricle morphogenesis", "Cardioblast differentiation", "Cardioblast proliferation", "Cardiocyte differentiation", "Cardiolipin acyl chain remodeling", "Cardiolipin metabolic process", "Carnitine metabolic process", "Carnitine transport", "Cartilage development", "Cartilage development involved in endochondral bone morphogenesis", "Catechol containing compound biosynthetic process", "Catechol containing compound catabolic process", "Catechol containing compound metabolic process", "Catecholamine uptake", "Catecholamine uptake involved in synaptic transmission", "Cation transmembrane transport", "Cation transport", "Caveola assembly", "Caveolin mediated endocytosis", "Cd4 positive alpha beta t cell activation", "Cd4 positive alpha beta t cell differentiation", "Cd4 positive alpha beta t cell proliferation", "Cd4 positive or cd8 positive alpha beta t cell lineage commitment", "Cd40 signaling pathway", "Cd8 positive alpha beta t cell activation", "Cd8 positive alpha beta t cell differentiation", "Cd8 positive alpha beta t cell proliferation", "Cdc42 protein signal transduction", "Cdp choline pathway", "Cdp diacylglycerol metabolic process", "Cell activation", "Cell activation involved in immune response", "Cell adhesion mediated by integrin", "Cell adhesion molecule production", "Cell aggregation", "Cell aging", "Cell cell adhesion", "Cell cell adhesion mediated by cadherin", "Cell cell adhesion mediated by integrin", "Cell cell adhesion via plasma membrane adhesion molecules", "Cell cell junction assembly", "Cell cell junction maintenance", "Cell cell junction organization", "Cell cell recognition", "Cell cell signaling", "Cell cell signaling by wnt", "Cell cell signaling involved in cardiac conduction", "Cell chemotaxis", "Cell communication by electrical coupling", "Cell communication by electrical coupling involved in cardiac conduction", "Cell communication involved in cardiac conduction", "Cell cycle", "Cell cycle checkpoint signaling", "Cell cycle dna replication", "Cell cycle dna replication initiation", "Cell cycle g1 s phase transition", "Cell cycle g2 m phase transition", "Cell cycle phase transition", "Cell cycle process", "Cell death in response to hydrogen peroxide", "Cell death in response to oxidative stress", "Cell differentiation in hindbrain", "Cell differentiation in spinal cord", "Cell differentiation involved in embryonic placenta development", "Cell differentiation involved in kidney development", "Cell differentiation involved in metanephros development", "Cell differentiation involved in phenotypic switching", "Cell division", "Cell fate commitment", "Cell fate commitment involved in formation of primary germ layer", "Cell fate determination", "Cell fate specification", "Cell growth", "Cell junction assembly", "Cell junction disassembly", "Cell junction maintenance", "Cell junction organization", "Cell killing", "Cell matrix adhesion", "Cell maturation", "Cell migration", "Cell migration in hindbrain", "Cell migration involved in gastrulation", "Cell migration involved in heart development", "Cell migration involved in sprouting angiogenesis", "Cell morphogenesis", "Cell morphogenesis involved in differentiation", "Cell morphogenesis involved in neuron differentiation", "Cell motility involved in cerebral cortex radial glia guided migration", "Cell part morphogenesis", "Cell projection assembly", "Cell projection organization", "Cell proliferation in forebrain", "Cell proliferation in hindbrain", "Cell proliferation involved in heart morphogenesis", "Cell proliferation involved in kidney development", "Cell proliferation involved in metanephros development", "Cell recognition", "Cell redox homeostasis", "Cell substrate adhesion", "Cell substrate junction organization", "Cell surface receptor signaling pathway involved in cell cell signaling", "Cell surface receptor signaling pathway involved in heart development", "Cell volume homeostasis", "Cellular aldehyde metabolic process", "Cellular amide metabolic process", "Cellular amino acid biosynthetic process", "Cellular amino acid catabolic process", "Cellular amino acid metabolic process", "Cellular anion homeostasis", "Cellular carbohydrate biosynthetic process", "Cellular carbohydrate catabolic process", "Cellular carbohydrate metabolic process", "Cellular component assembly involved in morphogenesis", "Cellular component disassembly", "Cellular component disassembly involved in execution phase of apoptosis", "Cellular component maintenance", "Cellular component morphogenesis", "Cellular copper ion homeostasis", "Cellular defense response", "Cellular detoxification of aldehyde", "Cellular extravasation", "Cellular glucan metabolic process", "Cellular glucose homeostasis", "Cellular homeostasis", "Cellular hormone metabolic process", "Cellular hyperosmotic response", "Cellular hyperosmotic salinity response", "Cellular hypotonic response", "Cellular ion homeostasis", "Cellular iron ion homeostasis", "Cellular ketone metabolic process", "Cellular lipid catabolic process", "Cellular lipid metabolic process", "Cellular macromolecule biosynthetic process", "Cellular macromolecule localization", "Cellular metabolic compound salvage", "Cellular modified amino acid biosynthetic process", "Cellular modified amino acid catabolic process", "Cellular modified amino acid metabolic process", "Cellular monovalent inorganic anion homeostasis", "Cellular monovalent inorganic cation homeostasis", "Cellular nitrogen compound catabolic process", "Cellular oxidant detoxification", "Cellular pigmentation", "Cellular polysaccharide catabolic process", "Cellular potassium ion homeostasis", "Cellular process involved in reproduction in multicellular organism", "Cellular protein catabolic process", "Cellular respiration", "Cellular response to abiotic stimulus", "Cellular response to acid chemical", "Cellular response to acidic ph", "Cellular response to alcohol", "Cellular response to aldehyde", "Cellular response to alkaloid", "Cellular response to amyloid beta", "Cellular response to antibiotic", "Cellular response to arsenic containing substance", "Cellular response to atp", "Cellular response to biotic stimulus", "Cellular response to brain derived neurotrophic factor stimulus", "Cellular response to cadmium ion", "Cellular response to caffeine", "Cellular response to calcium ion", "Cellular response to camp", "Cellular response to carbohydrate stimulus", "Cellular response to chemical stress", "Cellular response to cholesterol", "Cellular response to cocaine", "Cellular response to cold", "Cellular response to copper ion", "Cellular response to corticosteroid stimulus", "Cellular response to dexamethasone stimulus", "Cellular response to dna damage stimulus", "Cellular response to dsrna", "Cellular response to electrical stimulus", "Cellular response to endogenous stimulus", "Cellular response to epinephrine stimulus", "Cellular response to estradiol stimulus", "Cellular response to estrogen stimulus", "Cellular response to ethanol", "Cellular response to ether", "Cellular response to exogenous dsrna", "Cellular response to external stimulus", "Cellular response to extracellular stimulus", "Cellular response to fatty acid", "Cellular response to fluid shear stress", "Cellular response to follicle stimulating hormone stimulus", "Cellular response to gamma radiation", "Cellular response to glucose starvation", "Cellular response to gonadotropin stimulus", "Cellular response to growth hormone stimulus", "Cellular response to heat", "Cellular response to heparin", "Cellular response to histamine", "Cellular response to hormone stimulus", "Cellular response to hydrogen peroxide", "Cellular response to hydroperoxide", "Cellular response to hyperoxia", "Cellular response to increased oxygen levels", "Cellular response to indole 3 methanol", "Cellular response to inorganic substance", "Cellular response to insulin like growth factor stimulus", "Cellular response to insulin stimulus", "Cellular response to interferon alpha", "Cellular response to interferon beta", "Cellular response to interferon gamma", "Cellular response to interleukin 1", "Cellular response to ionizing radiation", "Cellular response to iron ion", "Cellular response to ketone", "Cellular response to leptin stimulus", "Cellular response to leucine", "Cellular response to leucine starvation", "Cellular response to light intensity", "Cellular response to light stimulus", "Cellular response to lipid", "Cellular response to lipoprotein particle stimulus", "Cellular response to lithium ion", "Cellular response to low density lipoprotein particle stimulus", "Cellular response to magnesium ion", "Cellular response to manganese ion", "Cellular response to mechanical stimulus", "Cellular response to mineralocorticoid stimulus", "Cellular response to molecule of bacterial origin", "Cellular response to muramyl dipeptide", "Cellular response to nitrogen compound", "Cellular response to nitrogen starvation", "Cellular response to nitrosative stress", "Cellular response to nutrient", "Cellular response to organic cyclic compound", "Cellular response to osmotic stress", "Cellular response to oxidised low density lipoprotein particle stimulus", "Cellular response to oxygen containing compound", "Cellular response to oxygen glucose deprivation", "Cellular response to oxygen levels", "Cellular response to oxygen radical", "Cellular response to parathyroid hormone stimulus", "Cellular response to peptide", "Cellular response to peptide hormone stimulus", "Cellular response to peptidoglycan", "Cellular response to ph", "Cellular response to potassium ion", "Cellular response to prostaglandin e stimulus", "Cellular response to prostaglandin stimulus", "Cellular response to purine containing compound", "Cellular response to radiation", "Cellular response to reactive nitrogen species", "Cellular response to reactive oxygen species", "Cellular response to retinoic acid", "Cellular response to salt", "Cellular response to salt stress", "Cellular response to sodium arsenite", "Cellular response to starvation", "Cellular response to steroid hormone stimulus", "Cellular response to sterol", "Cellular response to sterol depletion", "Cellular response to stress", "Cellular response to testosterone stimulus", "Cellular response to thyroid hormone stimulus", "Cellular response to topologically incorrect protein", "Cellular response to toxic substance", "Cellular response to unfolded protein", "Cellular response to uv", "Cellular response to uv a", "Cellular response to uv c", "Cellular response to vascular endothelial growth factor stimulus", "Cellular response to virus", "Cellular response to vitamin", "Cellular response to vitamin d", "Cellular response to water stimulus", "Cellular response to x ray", "Cellular response to xenobiotic stimulus", "Cellular response to zinc ion", "Cellular senescence", "Cellular sodium ion homeostasis", "Cellular sphingolipid homeostasis", "Cellular transition metal ion homeostasis", "Cellular triglyceride homeostasis", "Cellular trivalent inorganic anion homeostasis", "Cenp a containing chromatin organization", "Central nervous system development", "Central nervous system maturation", "Central nervous system neuron axonogenesis", "Central nervous system neuron development", "Central nervous system neuron differentiation", "Central nervous system projection neuron axonogenesis", "Centriole assembly", "Centriole centriole cohesion", "Centriole elongation", "Centromere complex assembly", "Centromeric sister chromatid cohesion", "Centrosome duplication", "Centrosome separation", "Ceramide 1 phosphate transport", "Ceramide biosynthetic process", "Ceramide catabolic process", "Ceramide metabolic process", "Ceramide transport", "Cerebellar cortex development", "Cerebellar cortex formation", "Cerebellar cortex morphogenesis", "Cerebellar granular layer development", "Cerebellar granular layer formation", "Cerebellar granular layer morphogenesis", "Cerebellar purkinje cell layer development", "Cerebellar purkinje cell layer formation", "Cerebellar purkinje cell layer morphogenesis", "Cerebral cortex cell migration", "Cerebral cortex development", "Cerebral cortex neuron differentiation", "Cerebral cortex radially oriented cell migration", "Cerebral cortex regionalization", "Cerebral cortex tangential migration", "Cerebrospinal fluid circulation", "Cgmp mediated signaling", "Changes to dna methylation involved in embryo development", "Chaperone cofactor dependent protein refolding", "Chaperone mediated autophagy", "Chaperone mediated protein complex assembly", "Chaperone mediated protein folding", "Chemical homeostasis", "Chemical homeostasis within a tissue", "Chemical synaptic transmission postsynaptic", "Chemokine c c motif ligand 5 production", "Chemokine c x c motif ligand 12 signaling pathway", "Chemokine c x c motif ligand 2 production", "Chemokine production", "Chemosensory behavior", "Chloride transmembrane transport", "Chloride transport", "Cholesterol catabolic process", "Cholesterol efflux", "Cholesterol storage", "Choline metabolic process", "Choline transport", "Chondrocyte development", "Chondrocyte development involved in endochondral bone morphogenesis", "Chondrocyte differentiation", "Chondrocyte differentiation involved in endochondral bone morphogenesis", "Chondrocyte proliferation", "Chondroitin sulfate biosynthetic process", "Chondroitin sulfate proteoglycan biosynthetic process", "Chondroitin sulfate proteoglycan metabolic process", "Chorion development", "Chromatin assembly or disassembly", "Chromatin disassembly", "Chromatin organization", "Chromatin remodeling", "Chromatin remodeling at centromere", "Chromosome attachment to the nuclear envelope", "Chromosome condensation", "Chromosome localization", "Chromosome localization to nuclear envelope involved in homologous chromosome segregation", "Chromosome movement towards spindle pole", "Chromosome organization", "Chromosome organization involved in meiotic cell cycle", "Chromosome segregation", "Chromosome separation", "Cilium movement", "Cilium or flagellum dependent cell motility", "Cilium organization", "Circadian regulation of gene expression", "Circadian rhythm", "Circulatory system development", "Circulatory system process", "Citrate metabolic process", "Citrulline biosynthetic process", "Citrulline metabolic process", "Clathrin coat assembly", "Clathrin dependent endocytosis", "Cleavage furrow formation", "Cleavage involved in rrna processing", "Cobalamin metabolic process", "Cobalt ion transport", "Cochlea development", "Cochlea morphogenesis", "Coenzyme a biosynthetic process", "Coenzyme a metabolic process", "Cognition", "Cohesin loading", "Collagen biosynthetic process", "Collagen catabolic process", "Collagen fibril organization", "Collagen metabolic process", "Collateral sprouting", "Collateral sprouting in absence of injury", "Collecting duct development", "Columnar cuboidal epithelial cell development", "Columnar cuboidal epithelial cell differentiation", "Columnar cuboidal epithelial cell maturation", "Commissural neuron axon guidance", "Common partner smad protein phosphorylation", "Complement activation", "Complement dependent cytotoxicity", "Connective tissue development", "Connective tissue replacement", "Constitutive heterochromatin assembly", "Constitutive secretory pathway", "Convergent extension", "Convergent extension involved in axis elongation", "Convergent extension involved in gastrulation", "Cop9 signalosome assembly", "Copi coated vesicle budding", "Copii coated vesicle budding", "Copii coated vesicle cargo loading", "Copper ion homeostasis", "Copper ion import", "Copper ion transmembrane transport", "Copper ion transport", "Copulation", "Coronary artery morphogenesis", "Coronary vasculature development", "Coronary vasculature morphogenesis", "Corpus callosum development", "Corpus callosum morphogenesis", "Cortical actin cytoskeleton organization", "Cortical cytoskeleton organization", "Corticospinal tract morphogenesis", "Corticosteroid hormone secretion", "Corticosteroid receptor signaling pathway", "Cortisol secretion", "Cotranslational protein targeting to membrane", "Cranial ganglion development", "Cranial nerve development", "Cranial nerve morphogenesis", "Cranial nerve structural organization", "Cranial skeletal system development", "Craniofacial suture morphogenesis", "Crd mediated mrna stabilization", "Cristae formation", "Cyclic gmp amp transmembrane import across plasma membrane", "Cyclic nucleotide catabolic process", "Cyclic nucleotide mediated signaling", "Cyclic nucleotide metabolic process", "Cyclooxygenase pathway", "Cysteine metabolic process", "Cytidine to uridine editing", "Cytochrome complex assembly", "Cytokine mediated signaling pathway", "Cytokine production", "Cytokine production involved in immune response", "Cytokine production involved in inflammatory response", "Cytokinesis", "Cytokinetic process", "Cytoplasm organization", "Cytoplasmic microtubule organization", "Cytoplasmic pattern recognition receptor signaling pathway", "Cytoplasmic pattern recognition receptor signaling pathway in response to virus", "Cytoplasmic sequestering of nf kappab", "Cytoplasmic sequestering of protein", "Cytoplasmic sequestering of transcription factor", "Cytoplasmic translation", "Cytoplasmic translational elongation", "Cytoplasmic translational initiation", "Cytoskeleton dependent cytokinesis", "Cytoskeleton dependent intracellular transport", "Cytoskeleton organization", "Cytosolic calcium ion transport", "Cytosolic transport", "D amino acid transport", "Damp metabolic process", "De novo amp biosynthetic process", "De novo protein folding", "De novo pyrimidine nucleobase biosynthetic process", "Deadenylation dependent decapping of nuclear transcribed mrna", "Decidualization", "Dedifferentiation", "Defense response", "Defense response to bacterium", "Defense response to fungus", "Defense response to gram negative bacterium", "Defense response to gram positive bacterium", "Defense response to other organism", "Defense response to symbiont", "Defense response to tumor cell", "Definitive erythrocyte differentiation", "Definitive hemopoiesis", "Dehydroascorbic acid transport", "Delamination", "Demethylation", "Dendrite arborization", "Dendrite development", "Dendrite extension", "Dendrite morphogenesis", "Dendrite self avoidance", "Dendritic cell apoptotic process", "Dendritic cell chemotaxis", "Dendritic cell cytokine production", "Dendritic cell differentiation", "Dendritic cell migration", "Dendritic spine development", "Dendritic spine maintenance", "Dendritic spine morphogenesis", "Dendritic transport", "Dense core granule transport", "Deoxyribonucleoside catabolic process", "Deoxyribonucleoside diphosphate metabolic process", "Deoxyribonucleoside metabolic process", "Deoxyribonucleoside monophosphate biosynthetic process", "Deoxyribonucleoside monophosphate catabolic process", "Deoxyribonucleoside monophosphate metabolic process", "Deoxyribonucleoside triphosphate biosynthetic process", "Deoxyribonucleoside triphosphate catabolic process", "Deoxyribonucleoside triphosphate metabolic process", "Deoxyribonucleotide biosynthetic process", "Deoxyribose phosphate catabolic process", "Deoxyribose phosphate metabolic process", "Dephosphorylation", "Dephosphorylation of rna polymerase ii c terminal domain", "Depyrimidination", "Dermatan sulfate biosynthetic process", "Dermatan sulfate metabolic process", "Dermatan sulfate proteoglycan metabolic process", "Desmosome organization", "Detection of abiotic stimulus", "Detection of biotic stimulus", "Detection of cell density", "Detection of external biotic stimulus", "Detection of light stimulus", "Detection of mechanical stimulus", "Detection of molecule of bacterial origin", "Detection of muscle stretch", "Detection of other organism", "Detection of stimulus", "Detection of virus", "Detection of visible light", "Determination of adult lifespan", "Determination of digestive tract left right asymmetry", "Determination of dorsal ventral asymmetry", "Determination of liver left right asymmetry", "Determination of pancreatic left right asymmetry", "Detoxification", "Detoxification of copper ion", "Detoxification of nitrogen compound", "Development of primary female sexual characteristics", "Development of primary sexual characteristics", "Development of secondary female sexual characteristics", "Development of secondary sexual characteristics", "Developmental cell growth", "Developmental growth", "Developmental growth involved in morphogenesis", "Developmental induction", "Developmental maturation", "Developmental pigmentation", "Developmental process involved in reproduction", "Diacylglycerol biosynthetic process", "Diacylglycerol metabolic process", "Diadenosine polyphosphate catabolic process", "Diadenosine polyphosphate metabolic process", "Diapedesis", "Diaphragm development", "Dicarboxylic acid biosynthetic process", "Dicarboxylic acid catabolic process", "Dicarboxylic acid metabolic process", "Dicarboxylic acid transport", "Dichotomous subdivision of an epithelial terminal unit", "Dichotomous subdivision of terminal units involved in salivary gland branching", "Diencephalon development", "Diet induced thermogenesis", "Digestion", "Digestive system development", "Digestive system process", "Digestive tract morphogenesis", "Diol biosynthetic process", "Diol metabolic process", "Diphosphoinositol polyphosphate metabolic process", "Disaccharide metabolic process", "Diterpenoid biosynthetic process", "Divalent inorganic cation homeostasis", "Dna biosynthetic process", "Dna catabolic process", "Dna catabolic process endonucleolytic", "Dna catabolic process exonucleolytic", "Dna conformation change", "Dna damage induced protein phosphorylation", "Dna damage response signal transduction by p53 class mediator", "Dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest", "Dna damage response signal transduction resulting in transcription", "Dna dealkylation", "Dna dealkylation involved in dna repair", "Dna deamination", "Dna dependent dna replication", "Dna dependent dna replication maintenance of fidelity", "Dna double strand break processing", "Dna endoreduplication", "Dna geometric change", "Dna integration", "Dna integrity checkpoint signaling", "Dna ligation", "Dna ligation involved in dna repair", "Dna metabolic process", "Dna methylation", "Dna methylation dependent heterochromatin assembly", "Dna methylation involved in gamete generation", "Dna methylation on cytosine", "Dna methylation or demethylation", "Dna modification", "Dna packaging", "Dna protection", "Dna recombination", "Dna repair", "Dna replication", "Dna replication checkpoint signaling", "Dna replication dependent chromatin organization", "Dna replication independent chromatin organization", "Dna replication initiation", "Dna replication synthesis of rna primer", "Dna strand elongation", "Dna strand elongation involved in dna replication", "Dna synthesis involved in dna repair", "Dna templated transcription elongation", "Dna templated transcription initiation", "Dna templated transcription termination", "Dna topological change", "Dna unwinding involved in dna replication", "Dolichol metabolic process", "Dolichyl diphosphate biosynthetic process", "Dopamine biosynthetic process", "Dopamine metabolic process", "Dopamine receptor signaling pathway", "Dopamine transport", "Dopaminergic neuron differentiation", "Dorsal aorta development", "Dorsal aorta morphogenesis", "Dorsal root ganglion development", "Dorsal ventral axis specification", "Dorsal ventral neural tube patterning", "Dorsal ventral pattern formation", "Dosage compensation", "Double strand break repair", "Double strand break repair involved in meiotic recombination", "Double strand break repair via break induced replication", "Double strand break repair via classical nonhomologous end joining", "Double strand break repair via nonhomologous end joining", "Dsrna processing", "Dtmp metabolic process", "Dttp metabolic process", "Dump metabolic process", "Ear development", "Ear morphogenesis", "Early endosome to golgi transport", "Eating behavior", "Ectoderm development", "Ectodermal placode development", "Ectopic germ cell programmed cell death", "Egg activation", "Elastic fiber assembly", "Elastin metabolic process", "Electron transport chain", "Embryo development", "Embryo development ending in birth or egg hatching", "Embryo implantation", "Embryonic appendage morphogenesis", "Embryonic axis specification", "Embryonic body morphogenesis", "Embryonic brain development", "Embryonic camera type eye development", "Embryonic cleavage", "Embryonic cranial skeleton morphogenesis", "Embryonic digestive tract development", "Embryonic digestive tract morphogenesis", "Embryonic digit morphogenesis", "Embryonic forelimb morphogenesis", "Embryonic heart tube development", "Embryonic heart tube morphogenesis", "Embryonic hemopoiesis", "Embryonic hindlimb morphogenesis", "Embryonic morphogenesis", "Embryonic neurocranium morphogenesis", "Embryonic organ development", "Embryonic organ morphogenesis", "Embryonic pattern specification", "Embryonic placenta development", "Embryonic placenta morphogenesis", "Embryonic process involved in female pregnancy", "Embryonic skeletal joint development", "Embryonic skeletal joint morphogenesis", "Embryonic skeletal system development", "Embryonic skeletal system morphogenesis", "Embryonic viscerocranium morphogenesis", "Enamel mineralization", "Endocannabinoid signaling pathway", "Endocardial cushion development", "Endocardial cushion formation", "Endocardial cushion morphogenesis", "Endocardium development", "Endocardium morphogenesis", "Endochondral bone morphogenesis", "Endocrine hormone secretion", "Endocrine pancreas development", "Endocrine process", "Endocrine system development", "Endocytic recycling", "Endocytosis", "Endocytosis involved in viral entry into host cell", "Endoderm development", "Endoderm formation", "Endodermal cell differentiation", "Endodermal cell fate commitment", "Endomembrane system organization", "Endonucleolytic cleavage in 5 ets of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage in its1 to separate ssu rrna from 5 8s rrna and lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage involved in rrna processing", "Endoplasmic reticulum calcium ion homeostasis", "Endoplasmic reticulum localization", "Endoplasmic reticulum mannose trimming", "Endoplasmic reticulum membrane organization", "Endoplasmic reticulum organization", "Endoplasmic reticulum plasma membrane tethering", "Endoplasmic reticulum to cytosol transport", "Endoplasmic reticulum to golgi vesicle mediated transport", "Endoplasmic reticulum tubular network organization", "Endoplasmic reticulum unfolded protein response", "Endosomal lumen acidification", "Endosomal transport", "Endosomal vesicle fusion", "Endosome organization", "Endosome to lysosome transport", "Endosome to lysosome transport via multivesicular body sorting pathway", "Endosome to plasma membrane protein transport", "Endosome transport via multivesicular body sorting pathway", "Endothelial cell activation", "Endothelial cell apoptotic process", "Endothelial cell chemotaxis", "Endothelial cell development", "Endothelial cell fate commitment", "Endothelial cell migration", "Endothelial cell morphogenesis", "Endothelial cell proliferation", "Endothelin receptor signaling pathway", "Endothelium development", "Energy derivation by oxidation of organic compounds", "Energy homeostasis", "Energy reserve metabolic process", "Engulfment of apoptotic cell", "Ensheathment of neurons", "Enteroendocrine cell differentiation", "Entrainment of circadian clock", "Entry into host", "Entry of bacterium into host cell", "Enucleate erythrocyte differentiation", "Enzyme directed rrna pseudouridine synthesis", "Enzyme linked receptor protein signaling pathway", "Eosinophil activation", "Eosinophil chemotaxis", "Eosinophil mediated immunity", "Eosinophil migration", "Ephrin receptor signaling pathway", "Epiboly", "Epidermal cell differentiation", "Epidermis development", "Epidermis morphogenesis", "Epigenetic maintenance of chromatin in transcription competent conformation", "Epithelial cell apoptotic process", "Epithelial cell cell adhesion", "Epithelial cell development", "Epithelial cell differentiation", "Epithelial cell differentiation involved in kidney development", "Epithelial cell differentiation involved in prostate gland development", "Epithelial cell fate commitment", "Epithelial cell maturation", "Epithelial cell morphogenesis", "Epithelial cell proliferation", "Epithelial cell proliferation involved in lung morphogenesis", "Epithelial cell proliferation involved in prostate gland development", "Epithelial cilium movement involved in determination of left right asymmetry", "Epithelial fluid transport", "Epithelial structure maintenance", "Epithelial to mesenchymal transition", "Epithelial to mesenchymal transition involved in endocardial cushion formation", "Epithelial tube branching involved in lung morphogenesis", "Epithelial tube formation", "Epithelial tube morphogenesis", "Epithelium development", "Epoxide metabolic process", "Er associated misfolded protein catabolic process", "Er nucleus signaling pathway", "Er overload response", "Erad pathway", "Erbb signaling pathway", "Erbb2 signaling pathway", "Erk1 and erk2 cascade", "Error free translesion synthesis", "Error prone translesion synthesis", "Erythrocyte development", "Erythrocyte homeostasis", "Erythrocyte maturation", "Escrt complex disassembly", "Establishment of cell polarity", "Establishment of centrosome localization", "Establishment of endothelial barrier", "Establishment of endothelial intestinal barrier", "Establishment of epithelial cell apical basal polarity", "Establishment of epithelial cell polarity", "Establishment of golgi localization", "Establishment of lymphocyte polarity", "Establishment of meiotic spindle localization", "Establishment of mitochondrion localization", "Establishment of mitotic spindle localization", "Establishment of organelle localization", "Establishment of pigment granule localization", "Establishment of planar polarity involved in neural tube closure", "Establishment of planar polarity of embryonic epithelium", "Establishment of protein localization", "Establishment of protein localization to chromatin", "Establishment of protein localization to chromosome", "Establishment of protein localization to endoplasmic reticulum", "Establishment of protein localization to membrane", "Establishment of protein localization to mitochondrial membrane", "Establishment of protein localization to organelle", "Establishment of protein localization to plasma membrane", "Establishment of protein localization to telomere", "Establishment of protein localization to vacuole", "Establishment of rna localization", "Establishment of sister chromatid cohesion", "Establishment of spindle orientation", "Establishment of tissue polarity", "Establishment or maintenance of bipolar cell polarity", "Establishment or maintenance of cell polarity", "Establishment or maintenance of cytoskeleton polarity", "Establishment or maintenance of monopolar cell polarity", "Establishment or maintenance of transmembrane electrochemical gradient", "Estrogen biosynthetic process", "Estrogen metabolic process", "Estrous cycle", "Ethanol catabolic process", "Ethanol metabolic process", "Ethanol oxidation", "Ethanolamine containing compound metabolic process", "Ether biosynthetic process", "Ether metabolic process", "Excitatory synapse assembly", "Excretion", "Execution phase of apoptosis", "Exit from mitosis", "Exocrine pancreas development", "Exocrine system development", "Exocytic process", "Exocytosis", "Exonucleolytic catabolism of deadenylated mrna", "Exploration behavior", "Export across plasma membrane", "Export from cell", "External encapsulating structure organization", "Extracellular exosome assembly", "Extracellular matrix assembly", "Extracellular matrix disassembly", "Extracellular regulation of signal transduction", "Extracellular transport", "Extracellular vesicle biogenesis", "Extraembryonic membrane development", "Extrinsic apoptotic signaling pathway", "Extrinsic apoptotic signaling pathway via death domain receptors", "Eye morphogenesis", "Eye photoreceptor cell development", "Eye photoreceptor cell differentiation", "Eye pigmentation", "Eyelid development in camera type eye", "Face development", "Facial nerve morphogenesis", "Facial nerve structural organization", "Facultative heterochromatin assembly", "Farnesyl diphosphate metabolic process", "Fas signaling pathway", "Fat cell differentiation", "Fat cell proliferation", "Fat soluble vitamin metabolic process", "Fatty acid alpha oxidation", "Fatty acid beta oxidation", "Fatty acid beta oxidation using acyl coa dehydrogenase", "Fatty acid beta oxidation using acyl coa oxidase", "Fatty acid biosynthetic process", "Fatty acid catabolic process", "Fatty acid derivative biosynthetic process", "Fatty acid derivative catabolic process", "Fatty acid derivative metabolic process", "Fatty acid elongation", "Fatty acid homeostasis", "Fatty acid metabolic process", "Fatty acid omega oxidation", "Fatty acid transmembrane transport", "Fatty acid transport", "Fatty acyl coa biosynthetic process", "Fatty acyl coa catabolic process", "Fatty acyl coa metabolic process", "Fc epsilon receptor signaling pathway", "Fc gamma receptor signaling pathway", "Fc receptor mediated stimulatory signaling pathway", "Fc receptor signaling pathway", "Fear response", "Feeding behavior", "Female gamete generation", "Female meiosis chromosome segregation", "Female meiosis i", "Female meiotic nuclear division", "Female sex differentiation", "Fermentation", "Fertilization", "Fibroblast activation", "Fibroblast apoptotic process", "Fibroblast growth factor production", "Fibroblast growth factor receptor signaling pathway", "Fibroblast migration", "Fibroblast proliferation", "Filopodium assembly", "Flavin containing compound metabolic process", "Flavonoid metabolic process", "Fluid transport", "Foam cell differentiation", "Focal adhesion assembly", "Folate import across plasma membrane", "Folate transmembrane transport", "Folic acid containing compound biosynthetic process", "Folic acid containing compound catabolic process", "Folic acid containing compound metabolic process", "Folic acid metabolic process", "Folic acid transport", "Forebrain cell migration", "Forebrain development", "Forebrain generation of neurons", "Forebrain morphogenesis", "Forebrain neuron development", "Forebrain neuron differentiation", "Forebrain radial glial cell differentiation", "Forebrain regionalization", "Foregut morphogenesis", "Forelimb morphogenesis", "Formate metabolic process", "Formation of extrachromosomal circular dna", "Formation of primary germ layer", "Formation of translation preinitiation complex", "Free ubiquitin chain polymerization", "Fructose 1 6 bisphosphate metabolic process", "Fructose 2 6 bisphosphate metabolic process", "Fructose 6 phosphate metabolic process", "Fructose metabolic process", "Fructose transmembrane transport", "Fucose metabolic process", "Fucosylation", "Fungiform papilla development", "Fungiform papilla morphogenesis", "G protein coupled acetylcholine receptor signaling pathway", "G protein coupled glutamate receptor signaling pathway", "G protein coupled opioid receptor signaling pathway", "G protein coupled purinergic receptor signaling pathway", "G protein coupled receptor internalization", "G protein coupled receptor signaling pathway", "G protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger", "G protein coupled receptor signaling pathway involved in heart process", "G quadruplex dna unwinding", "G0 to g1 transition", "G1 to g0 transition", "Galactose catabolic process", "Galactose metabolic process", "Gamete generation", "Gamma aminobutyric acid metabolic process", "Gamma aminobutyric acid secretion", "Gamma aminobutyric acid signaling pathway", "Gamma aminobutyric acid transport", "Gamma delta t cell activation", "Ganglion development", "Ganglioside catabolic process", "Ganglioside metabolic process", "Gap junction assembly", "Gap junction mediated intercellular transport", "Gas homeostasis", "Gastrulation", "Gastrulation with mouth forming second", "Gdp mannose metabolic process", "Gdp metabolic process", "Gene silencing by rna", "Generation of precursor metabolites and energy", "Genitalia development", "Genitalia morphogenesis", "Genomic imprinting", "Germ cell development", "Germ cell migration", "Germ cell proliferation", "Germinal center b cell differentiation", "Germinal center formation", "Gland development", "Gland morphogenesis", "Glandular epithelial cell development", "Glandular epithelial cell differentiation", "Glial cell apoptotic process", "Glial cell development", "Glial cell differentiation", "Glial cell fate commitment", "Glial cell migration", "Glial cell proliferation", "Gliogenesis", "Glomerular epithelial cell development", "Glomerular epithelial cell differentiation", "Glomerular epithelium development", "Glomerular visceral epithelial cell migration", "Glomerulus development", "Glucan biosynthetic process", "Glucocorticoid biosynthetic process", "Glucocorticoid metabolic process", "Glucocorticoid secretion", "Glucosamine containing compound catabolic process", "Glucosamine containing compound metabolic process", "Glucose 6 phosphate metabolic process", "Glucose catabolic process", "Glucose import", "Glucose import across plasma membrane", "Glucose import in response to insulin stimulus", "Glucose metabolic process", "Glucosylceramide metabolic process", "Glutamate biosynthetic process", "Glutamate catabolic process", "Glutamate homeostasis", "Glutamate metabolic process", "Glutamate receptor signaling pathway", "Glutamate reuptake", "Glutamate secretion", "Glutamate secretion neurotransmission", "Glutamine family amino acid biosynthetic process", "Glutamine family amino acid catabolic process", "Glutamine family amino acid metabolic process", "Glutamine metabolic process", "Glutamine transport", "Glutathione catabolic process", "Glutathione metabolic process", "Glycerol 3 phosphate metabolic process", "Glycerol ether metabolic process", "Glycerolipid biosynthetic process", "Glycerolipid catabolic process", "Glycerolipid metabolic process", "Glycerophospholipid biosynthetic process", "Glycerophospholipid catabolic process", "Glycerophospholipid metabolic process", "Glycine biosynthetic process", "Glycine metabolic process", "Glycolipid biosynthetic process", "Glycolipid catabolic process", "Glycolipid transport", "Glycolytic fermentation", "Glycolytic process through fructose 6 phosphate", "Glycoprotein biosynthetic process", "Glycoprotein catabolic process", "Glycoprotein metabolic process", "Glycosaminoglycan catabolic process", "Glycoside catabolic process", "Glycoside metabolic process", "Glycosphingolipid biosynthetic process", "Glycosphingolipid metabolic process", "Glycosyl compound biosynthetic process", "Glycosyl compound catabolic process", "Glycosyl compound metabolic process", "Glycosylation", "Glycosylceramide catabolic process", "Glycosylceramide metabolic process", "Glyoxylate metabolic process", "Gmp biosynthetic process", "Gmp metabolic process", "Gmp salvage", "Golgi disassembly", "Golgi localization", "Golgi organization", "Golgi ribbon formation", "Golgi to endosome transport", "Golgi to lysosome transport", "Golgi to plasma membrane protein transport", "Golgi to plasma membrane transport", "Golgi to vacuole transport", "Golgi vesicle budding", "Golgi vesicle transport", "Gonadotropin secretion", "Gpi anchor metabolic process", "Granulocyte activation", "Granulocyte chemotaxis", "Granulocyte differentiation", "Granulocyte migration", "Granzyme mediated programmed cell death signaling pathway", "Grooming behavior", "Growth", "Growth hormone receptor signaling pathway via jak stat", "Growth hormone secretion", "Growth plate cartilage chondrocyte differentiation", "Growth plate cartilage development", "Gtp biosynthetic process", "Gtp metabolic process", "Guanine metabolic process", "Guanine nucleotide transmembrane transport", "Guanine nucleotide transport", "Hair cell differentiation", "Hair cycle phase", "Hair follicle maturation", "Hair follicle placode formation", "Hard palate development", "Head development", "Head morphogenesis", "Heart development", "Heart field specification", "Heart formation", "Heart growth", "Heart morphogenesis", "Heart process", "Heart trabecula morphogenesis", "Heart valve development", "Heart valve morphogenesis", "Heat acclimation", "Hematopoietic progenitor cell differentiation", "Hematopoietic stem cell differentiation", "Hematopoietic stem cell homeostasis", "Hematopoietic stem cell proliferation", "Heme transport", "Hemidesmosome assembly", "Hemoglobin biosynthetic process", "Hemoglobin metabolic process", "Hemostasis", "Heparan sulfate proteoglycan biosynthetic process", "Heparan sulfate proteoglycan biosynthetic process enzymatic modification", "Heparan sulfate proteoglycan biosynthetic process polysaccharide chain biosynthetic process", "Heparan sulfate proteoglycan metabolic process", "Hepatic stellate cell activation", "Hepaticobiliary system development", "Hepatocyte apoptotic process", "Hepatocyte differentiation", "Hepatocyte growth factor receptor signaling pathway", "Hepoxilin metabolic process", "Heterochromatin organization", "Heterophilic cell cell adhesion via plasma membrane cell adhesion molecules", "Heterotypic cell cell adhesion", "High density lipoprotein particle assembly", "High density lipoprotein particle clearance", "High density lipoprotein particle remodeling", "Hindbrain development", "Hindbrain maturation", "Hindbrain morphogenesis", "Hindbrain radial glia guided cell migration", "Hindlimb morphogenesis", "Hippo signaling", "Hippocampus development", "His purkinje system development", "Histamine production involved in inflammatory response", "Histamine secretion", "Histamine transport", "Histidine metabolic process", "Histone arginine methylation", "Histone deacetylation", "Histone dephosphorylation", "Histone deubiquitination", "Histone exchange", "Histone h2a acetylation", "Histone h2a k119 monoubiquitination", "Histone h2a k63 linked ubiquitination", "Histone h2a monoubiquitination", "Histone h2a phosphorylation", "Histone h2a ubiquitination", "Histone h2b ubiquitination", "Histone h3 acetylation", "Histone h3 deacetylation", "Histone h3 k14 acetylation", "Histone h3 k27 methylation", "Histone h3 k27 trimethylation", "Histone h3 k36 demethylation", "Histone h3 k36 methylation", "Histone h3 k36 trimethylation", "Histone h3 k4 demethylation", "Histone h3 k4 demethylation trimethyl h3 k4 specific", "Histone h3 k4 methylation", "Histone h3 k4 trimethylation", "Histone h3 k9 acetylation", "Histone h3 k9 demethylation", "Histone h3 k9 dimethylation", "Histone h3 k9 methylation", "Histone h3 k9 modification", "Histone h3 k9 trimethylation", "Histone h4 acetylation", "Histone h4 deacetylation", "Histone h4 k12 acetylation", "Histone h4 k16 acetylation", "Histone h4 k20 methylation", "Histone h4 k20 trimethylation", "Histone h4 k5 acetylation", "Histone h4 r3 methylation", "Histone lysine demethylation", "Histone methylation", "Histone modification", "Histone monoubiquitination", "Histone mrna catabolic process", "Histone mrna metabolic process", "Histone phosphorylation", "Histone serine phosphorylation", "Histone threonine phosphorylation", "Histone ubiquitination", "Homeostasis of number of cells", "Homeostasis of number of cells within a tissue", "Homeostatic process", "Homocysteine metabolic process", "Homologous chromosome pairing at meiosis", "Homologous chromosome segregation", "Homologous recombination", "Homophilic cell adhesion via plasma membrane adhesion molecules", "Homotypic cell cell adhesion", "Hormone biosynthetic process", "Hormone catabolic process", "Hormone mediated signaling pathway", "Hormone metabolic process", "Hormone transport", "Humoral immune response", "Humoral immune response mediated by circulating immunoglobulin", "Hyaluronan biosynthetic process", "Hyaluronan metabolic process", "Hydrogen peroxide biosynthetic process", "Hydrogen peroxide catabolic process", "Hydrogen peroxide metabolic process", "Hydrogen sulfide biosynthetic process", "Hydrogen sulfide metabolic process", "Hyperosmotic response", "Hyperosmotic salinity response", "Hypothalamus cell differentiation", "Hypothalamus cell migration", "Hypothalamus development", "Hypothalamus gonadotrophin releasing hormone neuron differentiation", "Hypotonic response", "Hypoxia inducible factor 1alpha signaling pathway", "I kappab kinase nf kappab signaling", "I kappab phosphorylation", "Icosanoid biosynthetic process", "Icosanoid catabolic process", "Icosanoid metabolic process", "Icosanoid transport", "Immune effector process", "Immune response", "Immune response regulating cell surface receptor signaling pathway", "Immune response regulating signaling pathway", "Immune response to tumor cell", "Immune system development", "Immunoglobulin production", "Immunoglobulin production involved in immunoglobulin mediated immune response", "Immunoglobulin v d j recombination", "Immunological synapse formation", "Imp biosynthetic process", "Imp catabolic process", "Imp metabolic process", "Imp salvage", "Import across plasma membrane", "Import into cell", "Import into nucleus", "In utero embryonic development", "Inclusion body assembly", "Indolalkylamine metabolic process", "Indole containing compound biosynthetic process", "Indole containing compound metabolic process", "Inflammasome complex assembly", "Inflammatory cell apoptotic process", "Inflammatory response", "Inflammatory response to antigenic stimulus", "Inflammatory response to wounding", "Innate immune response", "Innate immune response activating signal transduction", "Innate immune response in mucosa", "Inner cell mass cell differentiation", "Inner cell mass cell proliferation", "Inner dynein arm assembly", "Inner ear auditory receptor cell differentiation", "Inner ear morphogenesis", "Inner ear receptor cell development", "Inner ear receptor cell fate commitment", "Inner ear receptor cell stereocilium organization", "Inner mitochondrial membrane organization", "Innervation", "Inorganic anion transmembrane transport", "Inorganic anion transport", "Inorganic ion import across plasma membrane", "Inorganic ion transmembrane transport", "Inosine metabolic process", "Inositol lipid mediated signaling", "Inositol metabolic process", "Inositol phosphate catabolic process", "Inositol phosphate mediated signaling", "Inositol phosphate metabolic process", "Insulin like growth factor receptor signaling pathway", "Insulin metabolic process", "Insulin processing", "Insulin receptor signaling pathway", "Insulin secretion", "Insulin secretion involved in cellular response to glucose stimulus", "Integrated stress response signaling", "Integrin activation", "Integrin mediated signaling pathway", "Intercellular transport", "Interferon alpha production", "Interferon beta production", "Interferon gamma mediated signaling pathway", "Interferon gamma production", "Interleukin 1 alpha production", "Interleukin 1 mediated signaling pathway", "Interleukin 1 production", "Interleukin 10 production", "Interleukin 12 production", "Interleukin 13 production", "Interleukin 17 production", "Interleukin 18 production", "Interleukin 2 production", "Interleukin 23 production", "Interleukin 27 mediated signaling pathway", "Interleukin 6 mediated signaling pathway", "Interleukin 6 production", "Interleukin 8 production", "Intermediate filament based process", "Intermediate filament bundle assembly", "Intermediate filament organization", "Intermembrane lipid transfer", "Interstrand cross link repair", "Intestinal absorption", "Intestinal epithelial cell development", "Intestinal epithelial cell differentiation", "Intestinal hexose absorption", "Intestinal lipid absorption", "Intra golgi vesicle mediated transport", "Intracellular distribution of mitochondria", "Intracellular estrogen receptor signaling pathway", "Intracellular lipid transport", "Intracellular mrna localization", "Intracellular protein transmembrane transport", "Intracellular protein transport", "Intracellular receptor signaling pathway", "Intracellular sterol transport", "Intracellular transport", "Intracellular transport of virus", "Intraciliary retrograde transport", "Intraciliary transport", "Intraciliary transport involved in cilium assembly", "Intrinsic apoptotic signaling pathway", "Intrinsic apoptotic signaling pathway by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to dna damage", "Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "Intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "Intrinsic apoptotic signaling pathway in response to hypoxia", "Intrinsic apoptotic signaling pathway in response to osmotic stress", "Intrinsic apoptotic signaling pathway in response to oxidative stress", "Ion homeostasis", "Ion transmembrane transport", "Ion transport", "Ire1 mediated unfolded protein response", "Ires dependent viral translational initiation", "Iron coordination entity transport", "Iron import into cell", "Iron ion homeostasis", "Iron ion import across plasma membrane", "Iron ion transmembrane transport", "Iron ion transport", "Iron sulfur cluster assembly", "Isocitrate metabolic process", "Isoleucine metabolic process", "Isopentenyl diphosphate biosynthetic process", "Isoprenoid biosynthetic process", "Isoprenoid metabolic process", "Isotype switching to iga isotypes", "Isotype switching to igg isotypes", "Jnk cascade", "Keratan sulfate metabolic process", "Keratinization", "Keratinocyte development", "Keratinocyte differentiation", "Keratinocyte migration", "Keratinocyte proliferation", "Ketone biosynthetic process", "Ketone body biosynthetic process", "Ketone body metabolic process", "Ketone catabolic process", "Kidney epithelium development", "Kidney mesenchyme development", "Kidney morphogenesis", "Killing by host of symbiont cells", "Killing of cells of another organism", "Kinetochore assembly", "Kinetochore organization", "Kynurenine metabolic process", "L alanine transport", "L alpha amino acid transmembrane transport", "L amino acid transport", "L arginine import across plasma membrane", "L arginine transmembrane transport", "L ascorbic acid metabolic process", "L aspartate transmembrane transport", "L glutamate import across plasma membrane", "L glutamate transmembrane transport", "L histidine transmembrane transport", "L kynurenine metabolic process", "L lysine transmembrane transport", "L methionine salvage from methylthioadenosine", "L phenylalanine metabolic process", "L proline biosynthetic process", "L serine biosynthetic process", "L serine catabolic process", "L serine metabolic process", "L serine transport", "Labyrinthine layer blood vessel development", "Labyrinthine layer development", "Labyrinthine layer morphogenesis", "Lactate metabolic process", "Lactate transmembrane transport", "Lactation", "Lamellipodium assembly", "Lamellipodium morphogenesis", "Lamellipodium organization", "Late endosome to golgi transport", "Late endosome to lysosome transport", "Late endosome to vacuole transport", "Late endosome to vacuole transport via multivesicular body sorting pathway", "Lateral ventricle development", "Layer formation in cerebral cortex", "Learned vocalization behavior or vocal learning", "Learning", "Left right axis specification", "Left right pattern formation", "Lens development in camera type eye", "Lens fiber cell development", "Lens fiber cell differentiation", "Lens morphogenesis in camera type eye", "Leptin mediated signaling pathway", "Leucine catabolic process", "Leucine import across plasma membrane", "Leucine metabolic process", "Leucine transport", "Leukocyte adhesion to vascular endothelial cell", "Leukocyte aggregation", "Leukocyte apoptotic process", "Leukocyte cell cell adhesion", "Leukocyte chemotaxis", "Leukocyte degranulation", "Leukocyte differentiation", "Leukocyte homeostasis", "Leukocyte mediated cytotoxicity", "Leukocyte mediated immunity", "Leukocyte migration", "Leukocyte proliferation", "Leukocyte tethering or rolling", "Leukotriene b4 metabolic process", "Leukotriene biosynthetic process", "Leukotriene metabolic process", "Leydig cell differentiation", "Limb joint morphogenesis", "Limbic system development", "Linoleic acid metabolic process", "Lipid biosynthetic process", "Lipid catabolic process", "Lipid digestion", "Lipid droplet formation", "Lipid droplet organization", "Lipid export from cell", "Lipid glycosylation", "Lipid homeostasis", "Lipid import into cell", "Lipid localization", "Lipid metabolic process", "Lipid modification", "Lipid oxidation", "Lipid phosphorylation", "Lipid storage", "Lipid translocation", "Lipid transport across blood brain barrier", "Lipophagy", "Lipopolysaccharide mediated signaling pathway", "Lipoprotein biosynthetic process", "Lipoprotein catabolic process", "Lipoprotein localization", "Lipoprotein metabolic process", "Liposaccharide metabolic process", "Lipoxin metabolic process", "Liver morphogenesis", "Liver regeneration", "Localization within membrane", "Locomotion", "Locomotion involved in locomotory behavior", "Locomotor rhythm", "Locomotory behavior", "Locomotory exploration behavior", "Long chain fatty acid biosynthetic process", "Long chain fatty acid import across plasma membrane", "Long chain fatty acid metabolic process", "Long chain fatty acid transport", "Long chain fatty acyl coa biosynthetic process", "Long chain fatty acyl coa metabolic process", "Long term memory", "Long term synaptic depression", "Long term synaptic potentiation", "Low density lipoprotein particle clearance", "Low density lipoprotein receptor particle metabolic process", "Lung alveolus development", "Lung associated mesenchyme development", "Lung cell differentiation", "Lung epithelium development", "Lung morphogenesis", "Lung saccule development", "Lung secretory cell differentiation", "Luteinization", "Luteinizing hormone secretion", "Luteolysis", "Lymphocyte activation", "Lymphocyte activation involved in immune response", "Lymphocyte aggregation", "Lymphocyte anergy", "Lymphocyte apoptotic process", "Lymphocyte chemotaxis", "Lymphocyte costimulation", "Lymphocyte homeostasis", "Lymphocyte mediated immunity", "Lymphocyte migration", "Lymphoid progenitor cell differentiation", "Lysine catabolic process", "Lysine metabolic process", "Lysosomal lumen acidification", "Lysosomal membrane organization", "Lysosomal microautophagy", "Lysosomal protein catabolic process", "Lysosomal transport", "Lytic vacuole organization", "Macroautophagy", "Macromolecule catabolic process", "Macromolecule deacylation", "Macromolecule depalmitoylation", "Macrophage activation", "Macrophage apoptotic process", "Macrophage chemotaxis", "Macrophage cytokine production", "Macrophage differentiation", "Macrophage inflammatory protein 1 alpha production", "Macrophage migration", "Macrophage proliferation", "Macropinocytosis", "Magnesium ion homeostasis", "Magnesium ion transport", "Maintenance of animal organ identity", "Maintenance of apical basal cell polarity", "Maintenance of blood brain barrier", "Maintenance of cell number", "Maintenance of cell polarity", "Maintenance of centrosome location", "Maintenance of dna methylation", "Maintenance of dna repeat elements", "Maintenance of gastrointestinal epithelium", "Maintenance of lens transparency", "Maintenance of location", "Maintenance of location in cell", "Maintenance of organelle location", "Maintenance of postsynaptic specialization structure", "Maintenance of presynaptic active zone structure", "Maintenance of protein localization in endoplasmic reticulum", "Maintenance of protein localization in organelle", "Maintenance of protein location", "Maintenance of protein location in cell", "Maintenance of protein location in mitochondrion", "Maintenance of protein location in nucleus", "Maintenance of sister chromatid cohesion", "Maintenance of synapse structure", "Malate metabolic process", "Male gamete generation", "Male genitalia development", "Male mating behavior", "Male meiosis i", "Male meiotic nuclear division", "Male sex determination", "Male sex differentiation", "Malonyl coa metabolic process", "Mammalian oogenesis stage", "Mammary gland alveolus development", "Mammary gland branching involved in pregnancy", "Mammary gland development", "Mammary gland duct morphogenesis", "Mammary gland epithelial cell differentiation", "Mammary gland epithelial cell proliferation", "Mammary gland epithelium development", "Mammary gland involution", "Mammary gland morphogenesis", "Manganese ion transmembrane transport", "Manganese ion transport", "Mannose metabolic process", "Mannosylation", "Mapk cascade", "Mast cell activation", "Mast cell activation involved in immune response", "Mast cell cytokine production", "Maternal placenta development", "Maternal process involved in female pregnancy", "Mating", "Mating behavior", "Maturation of 5 8s rrna", "Maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of lsu rrna", "Maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of ssu rrna", "Maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Mature b cell differentiation", "Mature ribosome assembly", "Mda 5 signaling pathway", "Mechanoreceptor differentiation", "Mechanosensory behavior", "Medium chain fatty acid biosynthetic process", "Medium chain fatty acid catabolic process", "Medium chain fatty acid metabolic process", "Medium chain fatty acyl coa metabolic process", "Megakaryocyte development", "Megakaryocyte differentiation", "Meiosis i cell cycle process", "Meiosis ii cell cycle process", "Meiotic cell cycle", "Meiotic cell cycle checkpoint signaling", "Meiotic cell cycle phase transition", "Meiotic cell cycle process", "Meiotic chromosome condensation", "Meiotic chromosome segregation", "Meiotic chromosome separation", "Meiotic cytokinesis", "Meiotic dna double strand break formation", "Meiotic sister chromatid cohesion centromeric", "Meiotic spindle assembly", "Meiotic spindle organization", "Melanocyte differentiation", "Membrane biogenesis", "Membrane depolarization", "Membrane depolarization during action potential", "Membrane depolarization during cardiac muscle cell action potential", "Membrane disassembly", "Membrane docking", "Membrane fission", "Membrane fusion", "Membrane hyperpolarization", "Membrane invagination", "Membrane lipid biosynthetic process", "Membrane lipid catabolic process", "Membrane lipid metabolic process", "Membrane organization", "Membrane protein ectodomain proteolysis", "Membrane protein intracellular domain proteolysis", "Membrane protein proteolysis", "Membrane raft assembly", "Membrane raft localization", "Membrane raft organization", "Membrane repolarization", "Membrane repolarization during action potential", "Membrane repolarization during atrial cardiac muscle cell action potential", "Membrane repolarization during cardiac muscle cell action potential", "Membrane to membrane docking", "Membranous septum morphogenesis", "Memory", "Mesangial cell development", "Mesangial cell differentiation", "Mesenchymal cell development", "Mesenchymal cell differentiation", "Mesenchymal cell differentiation involved in kidney development", "Mesenchymal cell proliferation", "Mesenchymal cell proliferation involved in lung development", "Mesenchymal stem cell differentiation", "Mesenchymal stem cell proliferation", "Mesenchymal to epithelial transition", "Mesenchymal to epithelial transition involved in metanephros morphogenesis", "Mesenchyme development", "Mesenchyme morphogenesis", "Mesendoderm development", "Mesoderm development", "Mesoderm morphogenesis", "Mesodermal cell differentiation", "Mesonephric duct development", "Mesonephric tubule formation", "Mesonephric tubule morphogenesis", "Mesonephros development", "Metal ion export", "Metal ion homeostasis", "Metal ion transport", "Metanephric collecting duct development", "Metanephric epithelium development", "Metanephric glomerulus development", "Metanephric glomerulus vasculature development", "Metanephric mesenchymal cell differentiation", "Metanephric mesenchyme development", "Metanephric nephron development", "Metanephric nephron morphogenesis", "Metanephric nephron tubule epithelial cell differentiation", "Metanephric part of ureteric bud development", "Metanephric renal vesicle morphogenesis", "Metanephric tubule development", "Metanephros development", "Metanephros morphogenesis", "Metaphase anaphase transition of cell cycle", "Metaphase plate congression", "Metencephalon development", "Methionine biosynthetic process", "Methionine metabolic process", "Methylation", "Methylglyoxal metabolic process", "Methylguanosine cap decapping", "Mhc class i biosynthetic process", "Mhc class ii biosynthetic process", "Microglia differentiation", "Microglial cell activation", "Microglial cell proliferation", "Microtubule anchoring", "Microtubule anchoring at centrosome", "Microtubule anchoring at microtubule organizing center", "Microtubule based movement", "Microtubule based process", "Microtubule based transport", "Microtubule bundle formation", "Microtubule cytoskeleton organization", "Microtubule cytoskeleton organization involved in mitosis", "Microtubule depolymerization", "Microtubule nucleation", "Microtubule organizing center localization", "Microtubule organizing center organization", "Microtubule polymerization", "Microtubule polymerization or depolymerization", "Microvillus assembly", "Microvillus organization", "Midbody abscission", "Midbrain development", "Midbrain dopaminergic neuron differentiation", "Middle ear morphogenesis", "Minus end directed organelle transport along microtubule", "Mirna catabolic process", "Mirna loading onto risc involved in gene silencing by mirna", "Mirna metabolic process", "Mismatch repair", "Mitochondrial acetyl coa biosynthetic process from pyruvate", "Mitochondrial adp transmembrane transport", "Mitochondrial atp synthesis coupled proton transport", "Mitochondrial calcium ion homeostasis", "Mitochondrial calcium ion transmembrane transport", "Mitochondrial cytochrome c oxidase assembly", "Mitochondrial depolarization", "Mitochondrial dna metabolic process", "Mitochondrial dna repair", "Mitochondrial dna replication", "Mitochondrial electron transport cytochrome c to oxygen", "Mitochondrial electron transport nadh to ubiquinone", "Mitochondrial electron transport ubiquinol to cytochrome c", "Mitochondrial fission", "Mitochondrial fragmentation involved in apoptotic process", "Mitochondrial fusion", "Mitochondrial gene expression", "Mitochondrial genome maintenance", "Mitochondrial membrane organization", "Mitochondrial outer membrane permeabilization", "Mitochondrial outer membrane permeabilization involved in programmed cell death", "Mitochondrial protein catabolic process", "Mitochondrial protein processing", "Mitochondrial proton transporting atp synthase complex assembly", "Mitochondrial respirasome assembly", "Mitochondrial respiratory chain complex assembly", "Mitochondrial ribosome assembly", "Mitochondrial rna 3 end processing", "Mitochondrial rna catabolic process", "Mitochondrial rna metabolic process", "Mitochondrial rna modification", "Mitochondrial rna processing", "Mitochondrial transcription", "Mitochondrial translation", "Mitochondrial translational elongation", "Mitochondrial transmembrane transport", "Mitochondrial transport", "Mitochondrial trna processing", "Mitochondrion distribution", "Mitochondrion endoplasmic reticulum membrane tethering", "Mitochondrion localization", "Mitochondrion morphogenesis", "Mitochondrion organization", "Mitophagy", "Mitotic cell cycle", "Mitotic cell cycle checkpoint signaling", "Mitotic cell cycle phase transition", "Mitotic cell cycle process", "Mitotic chromosome condensation", "Mitotic cytokinesis", "Mitotic cytokinetic process", "Mitotic dna integrity checkpoint signaling", "Mitotic dna replication", "Mitotic dna replication checkpoint signaling", "Mitotic g1 s transition checkpoint signaling", "Mitotic g2 dna damage checkpoint signaling", "Mitotic g2 m transition checkpoint", "Mitotic intra s dna damage checkpoint signaling", "Mitotic metaphase plate congression", "Mitotic nuclear division", "Mitotic nuclear membrane disassembly", "Mitotic nuclear membrane organization", "Mitotic recombination", "Mitotic sister chromatid cohesion", "Mitotic sister chromatid segregation", "Mitotic spindle assembly", "Mitotic spindle midzone assembly", "Mitotic spindle organization", "Modification dependent macromolecule catabolic process", "Modification of postsynaptic actin cytoskeleton", "Modification of postsynaptic structure", "Modification of synaptic structure", "Modified amino acid transport", "Modulation by host of symbiont catalytic activity", "Modulation by host of symbiont process", "Modulation by host of viral genome replication", "Modulation by host of viral process", "Modulation of age related behavioral decline", "Modulation of excitatory postsynaptic potential", "Molting cycle", "Monoacylglycerol catabolic process", "Monoacylglycerol metabolic process", "Monoamine transport", "Monocarboxylic acid biosynthetic process", "Monocarboxylic acid catabolic process", "Monocarboxylic acid metabolic process", "Monocarboxylic acid transport", "Monocyte chemotaxis", "Monocyte differentiation", "Monocyte extravasation", "Mononuclear cell differentiation", "Mononuclear cell migration", "Monosaccharide biosynthetic process", "Monosaccharide catabolic process", "Monosaccharide metabolic process", "Monoubiquitinated protein deubiquitination", "Monovalent inorganic anion homeostasis", "Monovalent inorganic cation homeostasis", "Morphogenesis of a branching structure", "Morphogenesis of a polarized epithelium", "Morphogenesis of an endothelium", "Morphogenesis of an epithelial bud", "Morphogenesis of an epithelial fold", "Morphogenesis of an epithelial sheet", "Morphogenesis of an epithelium", "Morphogenesis of embryonic epithelium", "Motor behavior", "Motor learning", "Motor neuron apoptotic process", "Motor neuron axon guidance", "Motor neuron migration", "Mrna 3 end processing", "Mrna 3 end processing by stem loop binding and cleavage", "Mrna 3 splice site recognition", "Mrna 5 splice site recognition", "Mrna alternative polyadenylation", "Mrna catabolic process", "Mrna cis splicing via spliceosome", "Mrna cleavage", "Mrna cleavage involved in mrna processing", "Mrna destabilization mediated gene silencing", "Mrna export from nucleus", "Mrna metabolic process", "Mrna methylation", "Mrna modification", "Mrna processing", "Mrna pseudouridine synthesis", "Mrna splice site selection", "Mrna transcription", "Mrna transport", "Mucopolysaccharide metabolic process", "Mucosa associated lymphoid tissue development", "Mucus secretion", "Multi multicellular organism process", "Multi organism reproductive process", "Multicellular organism aging", "Multicellular organism growth", "Multicellular organism reproduction", "Multicellular organismal homeostasis", "Multicellular organismal movement", "Multicellular organismal response to stress", "Multicellular organismal signaling", "Multivesicular body organization", "Multivesicular body sorting pathway", "Muscle adaptation", "Muscle cell apoptotic process", "Muscle cell cellular homeostasis", "Muscle cell development", "Muscle cell differentiation", "Muscle cell fate commitment", "Muscle cell migration", "Muscle cell proliferation", "Muscle contraction", "Muscle hypertrophy", "Muscle hypertrophy in response to stress", "Muscle organ development", "Muscle organ morphogenesis", "Muscle structure development", "Muscle system process", "Muscle tissue development", "Myd88 dependent toll like receptor signaling pathway", "Myelin assembly", "Myelin maintenance", "Myeloid cell activation involved in immune response", "Myeloid cell apoptotic process", "Myeloid cell development", "Myeloid cell differentiation", "Myeloid cell homeostasis", "Myeloid dendritic cell activation", "Myeloid dendritic cell cytokine production", "Myeloid dendritic cell differentiation", "Myeloid leukocyte activation", "Myeloid leukocyte cytokine production", "Myeloid leukocyte differentiation", "Myeloid leukocyte mediated immunity", "Myeloid leukocyte migration", "Myeloid progenitor cell differentiation", "Myoblast differentiation", "Myoblast fusion", "Myoblast migration", "Myofibroblast differentiation", "Myosin filament organization", "Myotube cell development", "Myotube differentiation", "N acetylglucosamine metabolic process", "N acetylneuraminate catabolic process", "N acetylneuraminate metabolic process", "N acylethanolamine metabolic process", "N glycan processing", "N terminal peptidyl methionine acetylation", "N terminal protein amino acid acetylation", "N terminal protein amino acid modification", "N terminal protein lipidation", "Nad biosynthesis via nicotinamide riboside salvage pathway", "Nad metabolic process", "Nadh dehydrogenase complex assembly", "Nadh metabolic process", "Nadh oxidation", "Nadh regeneration", "Nadp metabolic process", "Nadph regeneration", "Natural killer cell activation", "Natural killer cell activation involved in immune response", "Natural killer cell degranulation", "Natural killer cell differentiation", "Natural killer cell mediated immunity", "Ncrna 3 end processing", "Ncrna catabolic process", "Ncrna export from nucleus", "Ncrna metabolic process", "Ncrna processing", "Ncrna transcription", "Necroptotic signaling pathway", "Necrotic cell death", "Negative chemotaxis", "Negative regulation by host of viral genome replication", "Negative regulation by host of viral process", "Negative regulation by host of viral transcription", "Negative regulation of actin filament bundle assembly", "Negative regulation of actin filament depolymerization", "Negative regulation of actin filament polymerization", "Negative regulation of actin nucleation", "Negative regulation of activated t cell proliferation", "Negative regulation of activin receptor signaling pathway", "Negative regulation of adaptive immune response", "Negative regulation of adenylate cyclase activating adrenergic receptor signaling pathway", "Negative regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Negative regulation of adenylate cyclase activity", "Negative regulation of alcohol biosynthetic process", "Negative regulation of alpha beta t cell activation", "Negative regulation of alpha beta t cell differentiation", "Negative regulation of alpha beta t cell proliferation", "Negative regulation of amine transport", "Negative regulation of amino acid transport", "Negative regulation of amyloid beta clearance", "Negative regulation of amyloid fibril formation", "Negative regulation of amyloid precursor protein biosynthetic process", "Negative regulation of amyloid precursor protein catabolic process", "Negative regulation of androgen receptor signaling pathway", "Negative regulation of anion transmembrane transport", "Negative regulation of anion transport", "Negative regulation of anoikis", "Negative regulation of antigen receptor mediated signaling pathway", "Negative regulation of apoptotic signaling pathway", "Negative regulation of arp2 3 complex mediated actin nucleation", "Negative regulation of astrocyte differentiation", "Negative regulation of atp biosynthetic process", "Negative regulation of atp dependent activity", "Negative regulation of atp metabolic process", "Negative regulation of autophagosome assembly", "Negative regulation of autophagosome maturation", "Negative regulation of autophagy", "Negative regulation of autophagy of mitochondrion", "Negative regulation of axon extension", "Negative regulation of axon extension involved in axon guidance", "Negative regulation of axonogenesis", "Negative regulation of b cell activation", "Negative regulation of b cell apoptotic process", "Negative regulation of b cell differentiation", "Negative regulation of b cell mediated immunity", "Negative regulation of bicellular tight junction assembly", "Negative regulation of binding", "Negative regulation of biomineralization", "Negative regulation of biosynthetic process", "Negative regulation of blood circulation", "Negative regulation of blood pressure", "Negative regulation of blood vessel endothelial cell migration", "Negative regulation of bmp signaling pathway", "Negative regulation of bone remodeling", "Negative regulation of calcineurin mediated signaling", "Negative regulation of calcium ion dependent exocytosis", "Negative regulation of calcium ion import", "Negative regulation of calcium ion transmembrane transport", "Negative regulation of calcium ion transport", "Negative regulation of calcium ion transport into cytosol", "Negative regulation of calcium mediated signaling", "Negative regulation of camp dependent protein kinase activity", "Negative regulation of canonical wnt signaling pathway", "Negative regulation of carbohydrate metabolic process", "Negative regulation of cardiac muscle adaptation", "Negative regulation of cardiac muscle contraction", "Negative regulation of cardiac muscle tissue growth", "Negative regulation of cartilage development", "Negative regulation of catabolic process", "Negative regulation of catalytic activity", "Negative regulation of cation channel activity", "Negative regulation of cd4 positive alpha beta t cell activation", "Negative regulation of cd4 positive alpha beta t cell differentiation", "Negative regulation of cd4 positive alpha beta t cell proliferation", "Negative regulation of cell activation", "Negative regulation of cell adhesion", "Negative regulation of cell adhesion mediated by integrin", "Negative regulation of cell aging", "Negative regulation of cell cell adhesion", "Negative regulation of cell cell adhesion mediated by cadherin", "Negative regulation of cell cycle", "Negative regulation of cell cycle checkpoint", "Negative regulation of cell cycle g1 s phase transition", "Negative regulation of cell cycle g2 m phase transition", "Negative regulation of cell cycle phase transition", "Negative regulation of cell cycle process", "Negative regulation of cell death", "Negative regulation of cell development", "Negative regulation of cell differentiation", "Negative regulation of cell division", "Negative regulation of cell growth", "Negative regulation of cell growth involved in cardiac muscle cell development", "Negative regulation of cell junction assembly", "Negative regulation of cell killing", "Negative regulation of cell matrix adhesion", "Negative regulation of cell migration involved in sprouting angiogenesis", "Negative regulation of cell morphogenesis involved in differentiation", "Negative regulation of cell population proliferation", "Negative regulation of cell projection organization", "Negative regulation of cell size", "Negative regulation of cell substrate adhesion", "Negative regulation of cell substrate junction organization", "Negative regulation of cell volume", "Negative regulation of cellular amide metabolic process", "Negative regulation of cellular amine metabolic process", "Negative regulation of cellular catabolic process", "Negative regulation of cellular component organization", "Negative regulation of cellular macromolecule biosynthetic process", "Negative regulation of cellular protein catabolic process", "Negative regulation of cellular respiration", "Negative regulation of cellular response to growth factor stimulus", "Negative regulation of cellular response to hypoxia", "Negative regulation of cellular response to insulin stimulus", "Negative regulation of cellular response to vascular endothelial growth factor stimulus", "Negative regulation of cellular senescence", "Negative regulation of centriole replication", "Negative regulation of centrosome duplication", "Negative regulation of chemokine c c motif ligand 5 production", "Negative regulation of chemokine mediated signaling pathway", "Negative regulation of chemokine production", "Negative regulation of chemotaxis", "Negative regulation of cholesterol metabolic process", "Negative regulation of chondrocyte differentiation", "Negative regulation of chromatin binding", "Negative regulation of chromosome organization", "Negative regulation of cilium assembly", "Negative regulation of circadian rhythm", "Negative regulation of coagulation", "Negative regulation of cold induced thermogenesis", "Negative regulation of collateral sprouting", "Negative regulation of cyclic nucleotide phosphodiesterase activity", "Negative regulation of cyclin dependent protein serine threonine kinase activity", "Negative regulation of cysteine type endopeptidase activity", "Negative regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Negative regulation of cytokine production", "Negative regulation of cytokine production involved in immune response", "Negative regulation of cytokine production involved in inflammatory response", "Negative regulation of cytokinesis", "Negative regulation of cytoskeleton organization", "Negative regulation of cytosolic calcium ion concentration", "Negative regulation of defense response", "Negative regulation of defense response to bacterium", "Negative regulation of defense response to virus", "Negative regulation of delayed rectifier potassium channel activity", "Negative regulation of dendrite development", "Negative regulation of dendrite morphogenesis", "Negative regulation of dendritic spine development", "Negative regulation of dendritic spine morphogenesis", "Negative regulation of dephosphorylation", "Negative regulation of developmental growth", "Negative regulation of developmental process", "Negative regulation of dna binding", "Negative regulation of dna binding transcription factor activity", "Negative regulation of dna biosynthetic process", "Negative regulation of dna damage checkpoint", "Negative regulation of dna damage response signal transduction by p53 class mediator", "Negative regulation of dna dependent dna replication", "Negative regulation of dna metabolic process", "Negative regulation of dna recombination", "Negative regulation of dna repair", "Negative regulation of dna replication", "Negative regulation of dna templated transcription elongation", "Negative regulation of dna templated transcription initiation", "Negative regulation of double strand break repair via homologous recombination", "Negative regulation of double strand break repair via nonhomologous end joining", "Negative regulation of endocytosis", "Negative regulation of endoplasmic reticulum calcium ion concentration", "Negative regulation of endoplasmic reticulum stress induced eif2 alpha phosphorylation", "Negative regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Negative regulation of endoplasmic reticulum unfolded protein response", "Negative regulation of endothelial cell apoptotic process", "Negative regulation of endothelial cell proliferation", "Negative regulation of epidermal growth factor activated receptor activity", "Negative regulation of epidermis development", "Negative regulation of epithelial cell apoptotic process", "Negative regulation of epithelial cell differentiation", "Negative regulation of epithelial cell migration", "Negative regulation of epithelial cell proliferation", "Negative regulation of erad pathway", "Negative regulation of erbb signaling pathway", "Negative regulation of erk1 and erk2 cascade", "Negative regulation of erythrocyte differentiation", "Negative regulation of establishment of protein localization", "Negative regulation of establishment of protein localization to mitochondrion", "Negative regulation of excitatory postsynaptic potential", "Negative regulation of execution phase of apoptosis", "Negative regulation of exocytosis", "Negative regulation of extrinsic apoptotic signaling pathway", "Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Negative regulation of fat cell differentiation", "Negative regulation of fatty acid beta oxidation", "Negative regulation of fatty acid biosynthetic process", "Negative regulation of fatty acid metabolic process", "Negative regulation of fatty acid oxidation", "Negative regulation of fatty acid transport", "Negative regulation of fibroblast apoptotic process", "Negative regulation of fibroblast migration", "Negative regulation of fibroblast proliferation", "Negative regulation of filopodium assembly", "Negative regulation of g protein coupled receptor signaling pathway", "Negative regulation of gene expression", "Negative regulation of gene expression epigenetic", "Negative regulation of glial cell apoptotic process", "Negative regulation of glial cell differentiation", "Negative regulation of glial cell proliferation", "Negative regulation of gliogenesis", "Negative regulation of glucocorticoid metabolic process", "Negative regulation of gluconeogenesis", "Negative regulation of glucose import", "Negative regulation of glucose transmembrane transport", "Negative regulation of glycogen metabolic process", "Negative regulation of glycolytic process", "Negative regulation of glycoprotein metabolic process", "Negative regulation of golgi to plasma membrane protein transport", "Negative regulation of granulocyte chemotaxis", "Negative regulation of growth", "Negative regulation of gtpase activity", "Negative regulation of guanyl nucleotide exchange factor activity", "Negative regulation of heart rate", "Negative regulation of helicase activity", "Negative regulation of hematopoietic progenitor cell differentiation", "Negative regulation of hemopoiesis", "Negative regulation of hexokinase activity", "Negative regulation of hippo signaling", "Negative regulation of histone acetylation", "Negative regulation of histone deacetylation", "Negative regulation of histone h3 k27 methylation", "Negative regulation of histone h3 k4 methylation", "Negative regulation of histone h3 k9 methylation", "Negative regulation of histone h3 k9 trimethylation", "Negative regulation of histone h4 acetylation", "Negative regulation of histone methylation", "Negative regulation of histone modification", "Negative regulation of histone phosphorylation", "Negative regulation of homotypic cell cell adhesion", "Negative regulation of hormone biosynthetic process", "Negative regulation of hormone metabolic process", "Negative regulation of hormone secretion", "Negative regulation of hydrogen peroxide mediated programmed cell death", "Negative regulation of hydrolase activity", "Negative regulation of hypoxia induced intrinsic apoptotic signaling pathway", "Negative regulation of i kappab kinase nf kappab signaling", "Negative regulation of immune effector process", "Negative regulation of immune response", "Negative regulation of immune system process", "Negative regulation of immunoglobulin production", "Negative regulation of inclusion body assembly", "Negative regulation of inflammatory response", "Negative regulation of inflammatory response to antigenic stimulus", "Negative regulation of innate immune response", "Negative regulation of insulin secretion involved in cellular response to glucose stimulus", "Negative regulation of interferon gamma production", "Negative regulation of interleukin 1 beta production", "Negative regulation of interleukin 1 production", "Negative regulation of interleukin 12 production", "Negative regulation of interleukin 13 production", "Negative regulation of interleukin 17 production", "Negative regulation of interleukin 2 production", "Negative regulation of interleukin 6 production", "Negative regulation of interleukin 8 production", "Negative regulation of intracellular estrogen receptor signaling pathway", "Negative regulation of intracellular protein transport", "Negative regulation of intracellular signal transduction", "Negative regulation of intracellular steroid hormone receptor signaling pathway", "Negative regulation of intracellular transport", "Negative regulation of intrinsic apoptotic signaling pathway", "Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Negative regulation of ion transmembrane transport", "Negative regulation of ion transmembrane transporter activity", "Negative regulation of ion transport", "Negative regulation of ire1 mediated unfolded protein response", "Negative regulation of isotype switching", "Negative regulation of jnk cascade", "Negative regulation of jun kinase activity", "Negative regulation of keratinocyte differentiation", "Negative regulation of keratinocyte proliferation", "Negative regulation of kidney development", "Negative regulation of kinase activity", "Negative regulation of lamellipodium assembly", "Negative regulation of lamellipodium organization", "Negative regulation of leukocyte apoptotic process", "Negative regulation of leukocyte cell cell adhesion", "Negative regulation of leukocyte chemotaxis", "Negative regulation of leukocyte degranulation", "Negative regulation of leukocyte mediated immunity", "Negative regulation of leukocyte migration", "Negative regulation of leukocyte proliferation", "Negative regulation of lipase activity", "Negative regulation of lipid biosynthetic process", "Negative regulation of lipid catabolic process", "Negative regulation of lipid kinase activity", "Negative regulation of lipid localization", "Negative regulation of lipid metabolic process", "Negative regulation of lipid storage", "Negative regulation of lipid transport", "Negative regulation of lipopolysaccharide mediated signaling pathway", "Negative regulation of lipoprotein metabolic process", "Negative regulation of lipoprotein particle clearance", "Negative regulation of locomotion", "Negative regulation of low density lipoprotein particle clearance", "Negative regulation of low density lipoprotein receptor activity", "Negative regulation of lyase activity", "Negative regulation of lymphocyte activation", "Negative regulation of lymphocyte apoptotic process", "Negative regulation of lymphocyte differentiation", "Negative regulation of lymphocyte mediated immunity", "Negative regulation of lymphocyte migration", "Negative regulation of macroautophagy", "Negative regulation of macrophage chemotaxis", "Negative regulation of macrophage derived foam cell differentiation", "Negative regulation of macrophage migration", "Negative regulation of map kinase activity", "Negative regulation of mapk cascade", "Negative regulation of mast cell activation", "Negative regulation of mast cell activation involved in immune response", "Negative regulation of mast cell degranulation", "Negative regulation of megakaryocyte differentiation", "Negative regulation of meiotic cell cycle", "Negative regulation of meiotic nuclear division", "Negative regulation of membrane permeability", "Negative regulation of membrane potential", "Negative regulation of membrane protein ectodomain proteolysis", "Negative regulation of mesenchymal cell proliferation", "Negative regulation of metalloendopeptidase activity", "Negative regulation of metallopeptidase activity", "Negative regulation of metaphase anaphase transition of cell cycle", "Negative regulation of mhc class ii biosynthetic process", "Negative regulation of microtubule polymerization", "Negative regulation of microtubule polymerization or depolymerization", "Negative regulation of mirna transcription", "Negative regulation of mitochondrial fusion", "Negative regulation of mitochondrial membrane permeability", "Negative regulation of mitochondrial membrane permeability involved in apoptotic process", "Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Negative regulation of mitochondrion organization", "Negative regulation of mitophagy", "Negative regulation of mitotic cell cycle", "Negative regulation of mitotic cell cycle phase transition", "Negative regulation of molecular function", "Negative regulation of monocyte chemotaxis", "Negative regulation of mononuclear cell migration", "Negative regulation of monooxygenase activity", "Negative regulation of mrna 3 end processing", "Negative regulation of mrna catabolic process", "Negative regulation of mrna metabolic process", "Negative regulation of mrna processing", "Negative regulation of mrna splicing via spliceosome", "Negative regulation of multicellular organismal process", "Negative regulation of muscle adaptation", "Negative regulation of muscle cell apoptotic process", "Negative regulation of muscle cell differentiation", "Negative regulation of muscle contraction", "Negative regulation of muscle hypertrophy", "Negative regulation of muscle organ development", "Negative regulation of muscle tissue development", "Negative regulation of myelination", "Negative regulation of myeloid cell apoptotic process", "Negative regulation of myeloid cell differentiation", "Negative regulation of myeloid leukocyte differentiation", "Negative regulation of myeloid leukocyte mediated immunity", "Negative regulation of myoblast differentiation", "Negative regulation of myosin light chain phosphatase activity", "Negative regulation of myotube differentiation", "Negative regulation of natural killer cell mediated immunity", "Negative regulation of necrotic cell death", "Negative regulation of nervous system development", "Negative regulation of nervous system process", "Negative regulation of neural precursor cell proliferation", "Negative regulation of neuroblast proliferation", "Negative regulation of neuron apoptotic process", "Negative regulation of neuron death", "Negative regulation of neuron differentiation", "Negative regulation of neuron migration", "Negative regulation of neuron projection development", "Negative regulation of neurotransmitter secretion", "Negative regulation of neurotransmitter transport", "Negative regulation of neutrophil migration", "Negative regulation of nf kappab transcription factor activity", "Negative regulation of nik nf kappab signaling", "Negative regulation of nitric oxide metabolic process", "Negative regulation of nitric oxide synthase activity", "Negative regulation of nlrp3 inflammasome complex assembly", "Negative regulation of notch signaling pathway", "Negative regulation of nuclear division", "Negative regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Negative regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Negative regulation of nuclease activity", "Negative regulation of nucleobase containing compound metabolic process", "Negative regulation of nucleocytoplasmic transport", "Negative regulation of nucleotide biosynthetic process", "Negative regulation of nucleotide metabolic process", "Negative regulation of oligodendrocyte differentiation", "Negative regulation of organ growth", "Negative regulation of organelle assembly", "Negative regulation of organelle organization", "Negative regulation of organic acid transport", "Negative regulation of ossification", "Negative regulation of osteoblast proliferation", "Negative regulation of osteoclast differentiation", "Negative regulation of oxidative phosphorylation", "Negative regulation of oxidative stress induced cell death", "Negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Negative regulation of oxidative stress induced neuron death", "Negative regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway", "Negative regulation of oxidoreductase activity", "Negative regulation of p38mapk cascade", "Negative regulation of peptidase activity", "Negative regulation of peptide secretion", "Negative regulation of peptidyl cysteine s nitrosylation", "Negative regulation of peptidyl lysine acetylation", "Negative regulation of peptidyl serine phosphorylation", "Negative regulation of peptidyl threonine phosphorylation", "Negative regulation of peptidyl tyrosine phosphorylation", "Negative regulation of perk mediated unfolded protein response", "Negative regulation of phagocytosis", "Negative regulation of phosphatase activity", "Negative regulation of phosphatidylinositol 3 kinase signaling", "Negative regulation of phospholipase activity", "Negative regulation of phospholipid metabolic process", "Negative regulation of phosphoprotein phosphatase activity", "Negative regulation of phosphorus metabolic process", "Negative regulation of phosphorylation", "Negative regulation of plasma membrane bounded cell projection assembly", "Negative regulation of platelet activation", "Negative regulation of platelet derived growth factor receptor signaling pathway", "Negative regulation of posttranscriptional gene silencing", "Negative regulation of potassium ion transmembrane transport", "Negative regulation of potassium ion transport", "Negative regulation of production of mirnas involved in gene silencing by mirna", "Negative regulation of production of molecular mediator of immune response", "Negative regulation of programmed necrotic cell death", "Negative regulation of prostaglandin biosynthetic process", "Negative regulation of proteasomal protein catabolic process", "Negative regulation of proteasomal ubiquitin dependent protein catabolic process", "Negative regulation of protein acetylation", "Negative regulation of protein autophosphorylation", "Negative regulation of protein binding", "Negative regulation of protein catabolic process", "Negative regulation of protein containing complex assembly", "Negative regulation of protein containing complex disassembly", "Negative regulation of protein dephosphorylation", "Negative regulation of protein exit from endoplasmic reticulum", "Negative regulation of protein export from nucleus", "Negative regulation of protein import into nucleus", "Negative regulation of protein k63 linked ubiquitination", "Negative regulation of protein kinase activity by regulation of protein phosphorylation", "Negative regulation of protein kinase b signaling", "Negative regulation of protein localization", "Negative regulation of protein localization to cell periphery", "Negative regulation of protein localization to cell surface", "Negative regulation of protein localization to membrane", "Negative regulation of protein localization to nucleus", "Negative regulation of protein maturation", "Negative regulation of protein metabolic process", "Negative regulation of protein modification by small protein conjugation or removal", "Negative regulation of protein modification process", "Negative regulation of protein polymerization", "Negative regulation of protein polyubiquitination", "Negative regulation of protein secretion", "Negative regulation of protein serine threonine kinase activity", "Negative regulation of protein sumoylation", "Negative regulation of protein targeting to membrane", "Negative regulation of protein targeting to mitochondrion", "Negative regulation of protein tyrosine kinase activity", "Negative regulation of proteolysis", "Negative regulation of proteolysis involved in cellular protein catabolic process", "Negative regulation of reactive oxygen species biosynthetic process", "Negative regulation of reactive oxygen species metabolic process", "Negative regulation of receptor binding", "Negative regulation of receptor internalization", "Negative regulation of receptor mediated endocytosis", "Negative regulation of receptor signaling pathway via jak stat", "Negative regulation of receptor signaling pathway via stat", "Negative regulation of regulated secretory pathway", "Negative regulation of release of cytochrome c from mitochondria", "Negative regulation of reproductive process", "Negative regulation of respiratory burst", "Negative regulation of respiratory burst involved in inflammatory response", "Negative regulation of response to biotic stimulus", "Negative regulation of response to cytokine stimulus", "Negative regulation of response to dna damage stimulus", "Negative regulation of response to endoplasmic reticulum stress", "Negative regulation of response to external stimulus", "Negative regulation of response to food", "Negative regulation of response to oxidative stress", "Negative regulation of response to reactive oxygen species", "Negative regulation of response to stimulus", "Negative regulation of response to wounding", "Negative regulation of retinoic acid receptor signaling pathway", "Negative regulation of rho protein signal transduction", "Negative regulation of rig i signaling pathway", "Negative regulation of rna catabolic process", "Negative regulation of rna splicing", "Negative regulation of ruffle assembly", "Negative regulation of ryanodine sensitive calcium release channel activity", "Negative regulation of schwann cell proliferation", "Negative regulation of secondary metabolite biosynthetic process", "Negative regulation of secretion", "Negative regulation of sequestering of triglyceride", "Negative regulation of signal transduction by p53 class mediator", "Negative regulation of signal transduction in absence of ligand", "Negative regulation of signaling", "Negative regulation of signaling receptor activity", "Negative regulation of single stranded viral rna replication via double stranded dna intermediate", "Negative regulation of sister chromatid cohesion", "Negative regulation of small gtpase mediated signal transduction", "Negative regulation of small molecule metabolic process", "Negative regulation of smooth muscle cell apoptotic process", "Negative regulation of smooth muscle cell differentiation", "Negative regulation of smooth muscle cell migration", "Negative regulation of smooth muscle cell proliferation", "Negative regulation of smoothened signaling pathway", "Negative regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Negative regulation of sodium ion transmembrane transport", "Negative regulation of sodium ion transport", "Negative regulation of sprouting angiogenesis", "Negative regulation of stem cell differentiation", "Negative regulation of steroid metabolic process", "Negative regulation of stress activated protein kinase signaling cascade", "Negative regulation of striated muscle cell apoptotic process", "Negative regulation of striated muscle cell differentiation", "Negative regulation of striated muscle contraction", "Negative regulation of supramolecular fiber organization", "Negative regulation of synapse assembly", "Negative regulation of synapse organization", "Negative regulation of synaptic transmission", "Negative regulation of synaptic transmission glutamatergic", "Negative regulation of systemic arterial blood pressure", "Negative regulation of t cell apoptotic process", "Negative regulation of t cell differentiation", "Negative regulation of t cell proliferation", "Negative regulation of t cell receptor signaling pathway", "Negative regulation of t helper cell differentiation", "Negative regulation of telomerase activity", "Negative regulation of telomere capping", "Negative regulation of telomere maintenance", "Negative regulation of telomere maintenance via telomerase", "Negative regulation of telomere maintenance via telomere lengthening", "Negative regulation of thymocyte apoptotic process", "Negative regulation of tissue remodeling", "Negative regulation of tor signaling", "Negative regulation of transcription by competitive promoter binding", "Negative regulation of transcription by rna polymerase i", "Negative regulation of transcription by rna polymerase ii", "Negative regulation of transcription from rna polymerase ii promoter in response to stress", "Negative regulation of transcription initiation from rna polymerase ii promoter", "Negative regulation of transcription regulatory region dna binding", "Negative regulation of transferase activity", "Negative regulation of transforming growth factor beta production", "Negative regulation of transforming growth factor beta receptor signaling pathway", "Negative regulation of transforming growth factor beta1 production", "Negative regulation of translational elongation", "Negative regulation of translational initiation", "Negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Negative regulation of transmembrane transport", "Negative regulation of transport", "Negative regulation of transporter activity", "Negative regulation of trophoblast cell migration", "Negative regulation of tubulin deacetylation", "Negative regulation of tumor necrosis factor superfamily cytokine production", "Negative regulation of type 2 immune response", "Negative regulation of type b pancreatic cell apoptotic process", "Negative regulation of type i interferon mediated signaling pathway", "Negative regulation of type i interferon production", "Negative regulation of tyrosine phosphorylation of stat protein", "Negative regulation of ubiquitin dependent protein catabolic process", "Negative regulation of ubiquitin protein ligase activity", "Negative regulation of ubiquitin protein transferase activity", "Negative regulation of vascular associated smooth muscle cell apoptotic process", "Negative regulation of vascular associated smooth muscle cell differentiation", "Negative regulation of vascular associated smooth muscle cell migration", "Negative regulation of vascular associated smooth muscle cell proliferation", "Negative regulation of vascular endothelial growth factor production", "Negative regulation of vascular endothelial growth factor receptor signaling pathway", "Negative regulation of vascular permeability", "Negative regulation of vascular wound healing", "Negative regulation of vasculature development", "Negative regulation of viral entry into host cell", "Negative regulation of viral genome replication", "Negative regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Negative regulation of viral life cycle", "Negative regulation of viral process", "Negative regulation of viral transcription", "Negative regulation of vitamin metabolic process", "Negative regulation of voltage gated potassium channel activity", "Negative regulation of wnt signaling pathway", "Negative regulation of wound healing", "Nephric duct development", "Nephric duct morphogenesis", "Nephron development", "Nephron epithelium development", "Nephron morphogenesis", "Nephron tubule epithelial cell differentiation", "Nephron tubule formation", "Nerve development", "Nerve growth factor signaling pathway", "Nervous system process", "Nervous system process involved in regulation of systemic arterial blood pressure", "Netrin activated signaling pathway", "Neural crest cell differentiation", "Neural crest cell migration", "Neural crest cell migration involved in autonomic nervous system development", "Neural crest formation", "Neural nucleus development", "Neural plate development", "Neural plate morphogenesis", "Neural precursor cell proliferation", "Neural retina development", "Neural tube development", "Neural tube formation", "Neural tube patterning", "Neuroblast division", "Neuroblast proliferation", "Neuroendocrine cell differentiation", "Neuroepithelial cell differentiation", "Neurofilament cytoskeleton organization", "Neurogenesis", "Neuroinflammatory response", "Neuromuscular junction development", "Neuromuscular process", "Neuromuscular process controlling balance", "Neuromuscular process controlling posture", "Neuromuscular synaptic transmission", "Neuron apoptotic process", "Neuron cellular homeostasis", "Neuron death", "Neuron death in response to hydrogen peroxide", "Neuron death in response to oxidative stress", "Neuron development", "Neuron differentiation", "Neuron fate commitment", "Neuron fate determination", "Neuron fate specification", "Neuron intrinsic apoptotic signaling pathway in response to oxidative stress", "Neuron maturation", "Neuron migration", "Neuron projection arborization", "Neuron projection extension", "Neuron projection extension involved in neuron projection guidance", "Neuron projection guidance", "Neuron projection maintenance", "Neuron projection organization", "Neuron projection regeneration", "Neuron recognition", "Neuron remodeling", "Neuronal action potential", "Neuronal ion channel clustering", "Neuronal stem cell population maintenance", "Neuropeptide signaling pathway", "Neurotransmitter biosynthetic process", "Neurotransmitter catabolic process", "Neurotransmitter gated ion channel clustering", "Neurotransmitter metabolic process", "Neurotransmitter receptor internalization", "Neurotransmitter receptor localization to postsynaptic specialization membrane", "Neurotransmitter receptor transport", "Neurotransmitter receptor transport endosome to postsynaptic membrane", "Neurotransmitter receptor transport postsynaptic endosome to lysosome", "Neurotransmitter receptor transport to plasma membrane", "Neurotransmitter reuptake", "Neurotransmitter secretion", "Neurotransmitter transport", "Neurotransmitter uptake", "Neurotrophin production", "Neurotrophin signaling pathway", "Neurotrophin trk receptor signaling pathway", "Neutral amino acid transport", "Neutral lipid biosynthetic process", "Neutral lipid catabolic process", "Neutral lipid metabolic process", "Neutrophil activation involved in immune response", "Neutrophil apoptotic process", "Neutrophil chemotaxis", "Neutrophil clearance", "Neutrophil degranulation", "Neutrophil differentiation", "Neutrophil homeostasis", "Neutrophil mediated immunity", "Neutrophil migration", "Nik nf kappab signaling", "Nitric oxide mediated signal transduction", "Nitric oxide synthase biosynthetic process", "Nitrogen compound transport", "Nk t cell activation", "Nk t cell differentiation", "Nls bearing protein import into nucleus", "Non canonical wnt signaling pathway", "Non lytic viral release", "Non membrane bounded organelle assembly", "Non motile cilium assembly", "Nonribosomal peptide biosynthetic process", "Norepinephrine metabolic process", "Nose development", "Notch receptor processing", "Notch signaling involved in heart development", "Notch signaling pathway", "Nuclear body organization", "Nuclear chromosome segregation", "Nuclear envelope organization", "Nuclear export", "Nuclear membrane organization", "Nuclear membrane reassembly", "Nuclear migration", "Nuclear ncrna surveillance", "Nuclear pore complex assembly", "Nuclear pore organization", "Nuclear transcribed mrna catabolic process", "Nuclear transcribed mrna catabolic process deadenylation dependent decay", "Nuclear transcribed mrna catabolic process deadenylation independent decay", "Nuclear transcribed mrna catabolic process exonucleolytic", "Nuclear transcribed mrna catabolic process exonucleolytic 3 5", "Nuclear transcribed mrna catabolic process nonsense mediated decay", "Nuclear transcribed mrna poly a tail shortening", "Nuclear transport", "Nucleic acid phosphodiester bond hydrolysis", "Nucleobase biosynthetic process", "Nucleobase catabolic process", "Nucleobase containing compound transport", "Nucleobase containing small molecule biosynthetic process", "Nucleobase containing small molecule catabolic process", "Nucleobase containing small molecule interconversion", "Nucleobase containing small molecule metabolic process", "Nucleobase metabolic process", "Nucleobase transport", "Nucleolar chromatin organization", "Nucleolar large rrna transcription by rna polymerase i", "Nucleolus organization", "Nucleoside bisphosphate biosynthetic process", "Nucleoside bisphosphate catabolic process", "Nucleoside bisphosphate metabolic process", "Nucleoside catabolic process", "Nucleoside diphosphate biosynthetic process", "Nucleoside diphosphate catabolic process", "Nucleoside diphosphate metabolic process", "Nucleoside metabolic process", "Nucleoside monophosphate biosynthetic process", "Nucleoside monophosphate catabolic process", "Nucleoside monophosphate metabolic process", "Nucleoside monophosphate phosphorylation", "Nucleoside phosphate biosynthetic process", "Nucleoside phosphate catabolic process", "Nucleoside salvage", "Nucleoside transmembrane transport", "Nucleoside transport", "Nucleoside triphosphate biosynthetic process", "Nucleoside triphosphate catabolic process", "Nucleoside triphosphate metabolic process", "Nucleosome assembly", "Nucleosome mobilization", "Nucleosome organization", "Nucleosome positioning", "Nucleotide binding domain leucine rich repeat containing receptor signaling pathway", "Nucleotide binding oligomerization domain containing 2 signaling pathway", "Nucleotide excision repair", "Nucleotide excision repair dna gap filling", "Nucleotide excision repair dna incision", "Nucleotide phosphorylation", "Nucleotide salvage", "Nucleotide sugar biosynthetic process", "Nucleotide sugar metabolic process", "Nucleotide sugar transmembrane transport", "Nucleotide transmembrane transport", "Nucleotide transport", "Nucleus localization", "Nucleus organization", "O glycan processing", "Observational learning", "Odontoblast differentiation", "Odontogenesis", "Odontogenesis of dentin containing tooth", "Olefinic compound metabolic process", "Olfactory behavior", "Olfactory bulb interneuron development", "Olfactory bulb interneuron differentiation", "Olfactory lobe development", "Oligodendrocyte development", "Oligodendrocyte differentiation", "Oligodendrocyte progenitor proliferation", "Oligopeptide transport", "Oligosaccharide biosynthetic process", "Oligosaccharide catabolic process", "Oligosaccharide lipid intermediate biosynthetic process", "Oligosaccharide metabolic process", "One carbon metabolic process", "Oocyte construction", "Oocyte differentiation", "Oocyte maturation", "Oogenesis", "Optic nerve development", "Organ growth", "Organ induction", "Organ or tissue specific immune response", "Organelle assembly", "Organelle disassembly", "Organelle fission", "Organelle fusion", "Organelle inheritance", "Organelle localization", "Organelle membrane fusion", "Organelle transport along microtubule", "Organic acid biosynthetic process", "Organic acid catabolic process", "Organic acid metabolic process", "Organic acid transmembrane transport", "Organic acid transport", "Organic anion transport", "Organic cation transport", "Organic cyclic compound catabolic process", "Organic hydroxy compound biosynthetic process", "Organic hydroxy compound catabolic process", "Organic hydroxy compound metabolic process", "Organic hydroxy compound transport", "Organism emergence from protective structure", "Organonitrogen compound biosynthetic process", "Organonitrogen compound catabolic process", "Organophosphate biosynthetic process", "Organophosphate catabolic process", "Organophosphate ester transport", "Organophosphate metabolic process", "Ornithine metabolic process", "Ornithine transport", "Ossification", "Osteoblast differentiation", "Osteoblast proliferation", "Osteoclast development", "Osteoclast differentiation", "Otic vesicle development", "Otic vesicle formation", "Otic vesicle morphogenesis", "Otolith development", "Outer dynein arm assembly", "Outer ear morphogenesis", "Outer mitochondrial membrane organization", "Outflow tract morphogenesis", "Outflow tract septum morphogenesis", "Ovarian follicle development", "Oviduct development", "Ovulation", "Ovulation cycle", "Ovulation cycle process", "Ovulation from ovarian follicle", "Oxaloacetate metabolic process", "Oxaloacetate transport", "Oxidative demethylation", "Oxidative dna demethylation", "Oxidative phosphorylation", "Oxidative rna demethylation", "Oxygen homeostasis", "P body assembly", "P38mapk cascade", "Pallium development", "Pancreas development", "Pancreatic juice secretion", "Pantothenate metabolic process", "Parallel actin filament bundle assembly", "Paranodal junction assembly", "Parasympathetic nervous system development", "Parathyroid gland development", "Paraxial mesoderm development", "Paraxial mesoderm formation", "Paraxial mesoderm morphogenesis", "Parkin mediated stimulation of mitophagy in response to mitochondrial depolarization", "Pathway restricted smad protein phosphorylation", "Pattern recognition receptor signaling pathway", "Pattern specification involved in kidney development", "Pattern specification process", "Penetration of zona pellucida", "Penile erection", "Pentose catabolic process", "Pentose metabolic process", "Pentose phosphate shunt", "Pentose phosphate shunt non oxidative branch", "Peptide antigen assembly with mhc protein complex", "Peptide biosynthetic process", "Peptide catabolic process", "Peptide cross linking", "Peptide metabolic process", "Peptide modification", "Peptide transport", "Peptidyl amino acid modification", "Peptidyl arginine methylation", "Peptidyl arginine methylation to asymmetrical dimethyl arginine", "Peptidyl arginine modification", "Peptidyl arginine n methylation", "Peptidyl asparagine modification", "Peptidyl cysteine modification", "Peptidyl diphthamide biosynthetic process from peptidyl histidine", "Peptidyl glutamic acid modification", "Peptidyl glutamine methylation", "Peptidyl histidine modification", "Peptidyl l cysteine s palmitoylation", "Peptidyl lysine acetylation", "Peptidyl lysine deacetylation", "Peptidyl lysine dimethylation", "Peptidyl lysine hydroxylation", "Peptidyl lysine methylation", "Peptidyl lysine modification", "Peptidyl lysine monomethylation", "Peptidyl lysine trimethylation", "Peptidyl methionine modification", "Peptidyl proline hydroxylation", "Peptidyl proline hydroxylation to 4 hydroxy l proline", "Peptidyl proline modification", "Peptidyl serine autophosphorylation", "Peptidyl serine dephosphorylation", "Peptidyl serine modification", "Peptidyl threonine dephosphorylation", "Peptidyl threonine modification", "Peptidyl tyrosine autophosphorylation", "Peptidyl tyrosine dephosphorylation", "Peptidyl tyrosine dephosphorylation involved in inactivation of protein kinase activity", "Peptidyl tyrosine modification", "Pericyte cell differentiation", "Peripheral nervous system axon regeneration", "Peripheral nervous system development", "Peripheral nervous system myelin maintenance", "Peristalsis", "Perk mediated unfolded protein response", "Peroxisomal transport", "Peroxisome fission", "Peroxisome organization", "Peroxisome proliferator activated receptor signaling pathway", "Ph reduction", "Phagocytosis", "Phagocytosis recognition", "Phagolysosome assembly", "Phagosome acidification", "Phagosome lysosome fusion", "Phagosome maturation", "Pharyngeal system development", "Phasic smooth muscle contraction", "Phenol containing compound biosynthetic process", "Phenol containing compound catabolic process", "Phenol containing compound metabolic process", "Phenotypic switching", "Phosphagen metabolic process", "Phosphate ion transmembrane transport", "Phosphate ion transport", "Phosphatidic acid metabolic process", "Phosphatidylcholine acyl chain remodeling", "Phosphatidylcholine biosynthetic process", "Phosphatidylcholine catabolic process", "Phosphatidylcholine metabolic process", "Phosphatidylethanolamine biosynthetic process", "Phosphatidylethanolamine metabolic process", "Phosphatidylglycerol acyl chain remodeling", "Phosphatidylglycerol biosynthetic process", "Phosphatidylglycerol metabolic process", "Phosphatidylinositol 3 kinase signaling", "Phosphatidylinositol 3 phosphate biosynthetic process", "Phosphatidylinositol acyl chain remodeling", "Phosphatidylinositol biosynthetic process", "Phosphatidylinositol dephosphorylation", "Phosphatidylinositol metabolic process", "Phosphatidylinositol phosphate biosynthetic process", "Phosphatidylserine acyl chain remodeling", "Phosphatidylserine metabolic process", "Phospholipase c activating dopamine receptor signaling pathway", "Phospholipase c activating g protein coupled receptor signaling pathway", "Phospholipid biosynthetic process", "Phospholipid catabolic process", "Phospholipid dephosphorylation", "Phospholipid homeostasis", "Phospholipid metabolic process", "Phospholipid transport", "Phosphorylation", "Phosphorylation of rna polymerase ii c terminal domain", "Photoperiodism", "Photoreceptor cell development", "Photoreceptor cell differentiation", "Photoreceptor cell maintenance", "Photoreceptor cell outer segment organization", "Phototransduction", "Phototransduction visible light", "Physiological cardiac muscle hypertrophy", "Piecemeal microautophagy of the nucleus", "Pigment accumulation", "Pigment biosynthetic process", "Pigment cell differentiation", "Pigment granule localization", "Pigment granule maturation", "Pigment granule organization", "Pigment metabolic process", "Pigmentation", "Pinocytosis", "Pirna metabolic process", "Pituitary gland development", "Placenta blood vessel development", "Placenta development", "Planar cell polarity pathway involved in neural tube closure", "Plasma lipoprotein particle clearance", "Plasma membrane fusion", "Plasma membrane organization", "Plasma membrane phospholipid scrambling", "Plasma membrane raft assembly", "Plasma membrane raft organization", "Plasma membrane repair", "Plasma membrane to endosome transport", "Plasma membrane tubulation", "Plasminogen activation", "Platelet activating factor metabolic process", "Platelet activation", "Platelet aggregation", "Platelet dense granule organization", "Platelet derived growth factor receptor beta signaling pathway", "Platelet derived growth factor receptor signaling pathway", "Platelet morphogenesis", "Plus end directed organelle transport along microtubule", "Pml body organization", "Podosome assembly", "Pointed end actin filament capping", "Polarized epithelial cell differentiation", "Poly a plus mrna export from nucleus", "Poly n acetyllactosamine metabolic process", "Polyadenylation dependent rna catabolic process", "Polyadenylation dependent snorna 3 end processing", "Polyamine biosynthetic process", "Polyamine metabolic process", "Polyketide metabolic process", "Polyol biosynthetic process", "Polyol catabolic process", "Polyol metabolic process", "Polyprenol metabolic process", "Polysaccharide biosynthetic process", "Polysaccharide catabolic process", "Polysaccharide metabolic process", "Pons development", "Pore complex assembly", "Porphyrin containing compound metabolic process", "Positive chemotaxis", "Positive regulation by host of viral genome replication", "Positive regulation by host of viral process", "Positive regulation by host of viral transcription", "Positive regulation by symbiont of entry into host", "Positive regulation of 3 utr mediated mrna stabilization", "Positive regulation of actin cytoskeleton reorganization", "Positive regulation of actin filament bundle assembly", "Positive regulation of actin filament depolymerization", "Positive regulation of actin filament polymerization", "Positive regulation of actin nucleation", "Positive regulation of action potential", "Positive regulation of activated t cell proliferation", "Positive regulation of activin receptor signaling pathway", "Positive regulation of acute inflammatory response", "Positive regulation of acute inflammatory response to antigenic stimulus", "Positive regulation of adaptive immune response", "Positive regulation of adenylate cyclase activity", "Positive regulation of adipose tissue development", "Positive regulation of alcohol biosynthetic process", "Positive regulation of alpha beta t cell activation", "Positive regulation of alpha beta t cell differentiation", "Positive regulation of alpha beta t cell proliferation", "Positive regulation of amine transport", "Positive regulation of amino acid transport", "Positive regulation of amyloid beta clearance", "Positive regulation of amyloid beta formation", "Positive regulation of amyloid precursor protein biosynthetic process", "Positive regulation of amyloid precursor protein catabolic process", "Positive regulation of animal organ morphogenesis", "Positive regulation of anion transmembrane transport", "Positive regulation of anion transport", "Positive regulation of anoikis", "Positive regulation of antigen receptor mediated signaling pathway", "Positive regulation of apoptotic signaling pathway", "Positive regulation of arp2 3 complex mediated actin nucleation", "Positive regulation of aspartic type peptidase activity", "Positive regulation of astrocyte differentiation", "Positive regulation of atp biosynthetic process", "Positive regulation of atp dependent activity", "Positive regulation of atp metabolic process", "Positive regulation of atpase coupled calcium transmembrane transporter activity", "Positive regulation of attachment of spindle microtubules to kinetochore", "Positive regulation of autophagy", "Positive regulation of autophagy of mitochondrion", "Positive regulation of axon extension", "Positive regulation of axon extension involved in axon guidance", "Positive regulation of axonogenesis", "Positive regulation of b cell activation", "Positive regulation of b cell differentiation", "Positive regulation of b cell mediated immunity", "Positive regulation of b cell proliferation", "Positive regulation of basement membrane assembly involved in embryonic body morphogenesis", "Positive regulation of behavior", "Positive regulation of binding", "Positive regulation of biomineralization", "Positive regulation of blood brain barrier permeability", "Positive regulation of blood circulation", "Positive regulation of blood pressure", "Positive regulation of blood pressure by epinephrine norepinephrine", "Positive regulation of blood vessel endothelial cell migration", "Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Positive regulation of bmp signaling pathway", "Positive regulation of bone mineralization", "Positive regulation of bone resorption", "Positive regulation of brown fat cell differentiation", "Positive regulation of calcineurin mediated signaling", "Positive regulation of calcium ion dependent exocytosis", "Positive regulation of calcium ion import", "Positive regulation of calcium ion transmembrane transport", "Positive regulation of calcium ion transmembrane transporter activity", "Positive regulation of calcium ion transport", "Positive regulation of calcium ion transport into cytosol", "Positive regulation of calcium mediated signaling", "Positive regulation of camp dependent protein kinase activity", "Positive regulation of camp mediated signaling", "Positive regulation of canonical wnt signaling pathway", "Positive regulation of carbohydrate metabolic process", "Positive regulation of cardiac muscle cell proliferation", "Positive regulation of cardioblast differentiation", "Positive regulation of cardiocyte differentiation", "Positive regulation of cartilage development", "Positive regulation of catabolic process", "Positive regulation of catalytic activity", "Positive regulation of catecholamine metabolic process", "Positive regulation of cation channel activity", "Positive regulation of cd4 positive alpha beta t cell activation", "Positive regulation of cd4 positive alpha beta t cell differentiation", "Positive regulation of cd8 positive alpha beta t cell activation", "Positive regulation of cd8 positive alpha beta t cell differentiation", "Positive regulation of cell activation", "Positive regulation of cell adhesion", "Positive regulation of cell adhesion molecule production", "Positive regulation of cell aging", "Positive regulation of cell cell adhesion", "Positive regulation of cell cell adhesion mediated by cadherin", "Positive regulation of cell cycle", "Positive regulation of cell cycle checkpoint", "Positive regulation of cell cycle g1 s phase transition", "Positive regulation of cell cycle g2 m phase transition", "Positive regulation of cell cycle phase transition", "Positive regulation of cell cycle process", "Positive regulation of cell death", "Positive regulation of cell development", "Positive regulation of cell differentiation", "Positive regulation of cell division", "Positive regulation of cell growth", "Positive regulation of cell growth involved in cardiac muscle cell development", "Positive regulation of cell junction assembly", "Positive regulation of cell killing", "Positive regulation of cell matrix adhesion", "Positive regulation of cell maturation", "Positive regulation of cell migration by vascular endothelial growth factor signaling pathway", "Positive regulation of cell migration involved in sprouting angiogenesis", "Positive regulation of cell morphogenesis involved in differentiation", "Positive regulation of cell population proliferation", "Positive regulation of cell projection organization", "Positive regulation of cell proliferation involved in heart morphogenesis", "Positive regulation of cell size", "Positive regulation of cell substrate adhesion", "Positive regulation of cell substrate junction organization", "Positive regulation of cellular amide metabolic process", "Positive regulation of cellular amine metabolic process", "Positive regulation of cellular biosynthetic process", "Positive regulation of cellular carbohydrate metabolic process", "Positive regulation of cellular component biogenesis", "Positive regulation of cellular component organization", "Positive regulation of cellular extravasation", "Positive regulation of cellular ph reduction", "Positive regulation of cellular protein catabolic process", "Positive regulation of cellular respiration", "Positive regulation of cellular response to insulin stimulus", "Positive regulation of cellular response to transforming growth factor beta stimulus", "Positive regulation of centriole elongation", "Positive regulation of centriole replication", "Positive regulation of chemokine c c motif ligand 5 production", "Positive regulation of chemokine c x c motif ligand 2 production", "Positive regulation of chemokine production", "Positive regulation of chemotaxis", "Positive regulation of cholesterol biosynthetic process", "Positive regulation of cholesterol efflux", "Positive regulation of cholesterol metabolic process", "Positive regulation of cholesterol storage", "Positive regulation of chondrocyte differentiation", "Positive regulation of chondrocyte proliferation", "Positive regulation of chromatin binding", "Positive regulation of chromatin organization", "Positive regulation of chromosome condensation", "Positive regulation of chromosome organization", "Positive regulation of chromosome segregation", "Positive regulation of chromosome separation", "Positive regulation of cilium assembly", "Positive regulation of circadian rhythm", "Positive regulation of clathrin dependent endocytosis", "Positive regulation of coagulation", "Positive regulation of cold induced thermogenesis", "Positive regulation of collagen metabolic process", "Positive regulation of collateral sprouting", "Positive regulation of complement activation", "Positive regulation of connective tissue replacement", "Positive regulation of cyclase activity", "Positive regulation of cyclic nucleotide phosphodiesterase activity", "Positive regulation of cyclin dependent protein kinase activity", "Positive regulation of cysteine type endopeptidase activity", "Positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Positive regulation of cytokine production", "Positive regulation of cytokine production involved in immune response", "Positive regulation of cytokine production involved in inflammatory response", "Positive regulation of cytokinesis", "Positive regulation of cytoplasmic translation", "Positive regulation of cytoplasmic transport", "Positive regulation of cytoskeleton organization", "Positive regulation of deacetylase activity", "Positive regulation of defense response", "Positive regulation of defense response to virus by host", "Positive regulation of dendrite development", "Positive regulation of dendrite morphogenesis", "Positive regulation of dendritic cell cytokine production", "Positive regulation of dendritic cell differentiation", "Positive regulation of dendritic spine development", "Positive regulation of dendritic spine morphogenesis", "Positive regulation of deoxyribonuclease activity", "Positive regulation of dephosphorylation", "Positive regulation of developmental growth", "Positive regulation of developmental process", "Positive regulation of dna binding", "Positive regulation of dna binding transcription factor activity", "Positive regulation of dna biosynthetic process", "Positive regulation of dna damage response signal transduction by p53 class mediator", "Positive regulation of dna demethylation", "Positive regulation of dna dependent dna replication", "Positive regulation of dna ligation", "Positive regulation of dna metabolic process", "Positive regulation of dna methylation dependent heterochromatin assembly", "Positive regulation of dna recombination", "Positive regulation of dna repair", "Positive regulation of dna replication", "Positive regulation of dna templated transcription elongation", "Positive regulation of dna templated transcription initiation", "Positive regulation of dopamine receptor signaling pathway", "Positive regulation of double strand break repair", "Positive regulation of double strand break repair via homologous recombination", "Positive regulation of double strand break repair via nonhomologous end joining", "Positive regulation of early endosome to late endosome transport", "Positive regulation of embryonic development", "Positive regulation of endocytic recycling", "Positive regulation of endocytosis", "Positive regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Positive regulation of endoplasmic reticulum unfolded protein response", "Positive regulation of endothelial cell apoptotic process", "Positive regulation of endothelial cell chemotaxis", "Positive regulation of endothelial cell chemotaxis by vegf activated vascular endothelial growth factor receptor signaling pathway", "Positive regulation of endothelial cell development", "Positive regulation of endothelial cell differentiation", "Positive regulation of endothelial cell migration", "Positive regulation of endothelial cell proliferation", "Positive regulation of epidermal cell differentiation", "Positive regulation of epidermis development", "Positive regulation of epithelial cell apoptotic process", "Positive regulation of epithelial cell differentiation", "Positive regulation of epithelial cell migration", "Positive regulation of epithelial cell proliferation", "Positive regulation of epithelial cell proliferation involved in lung morphogenesis", "Positive regulation of epithelial to mesenchymal transition", "Positive regulation of er associated ubiquitin dependent protein catabolic process", "Positive regulation of erad pathway", "Positive regulation of erbb signaling pathway", "Positive regulation of erk1 and erk2 cascade", "Positive regulation of erythrocyte differentiation", "Positive regulation of establishment of protein localization", "Positive regulation of establishment of protein localization to mitochondrion", "Positive regulation of establishment of protein localization to telomere", "Positive regulation of excitatory postsynaptic potential", "Positive regulation of execution phase of apoptosis", "Positive regulation of exocytosis", "Positive regulation of exosomal secretion", "Positive regulation of extracellular matrix assembly", "Positive regulation of extracellular matrix disassembly", "Positive regulation of extracellular matrix organization", "Positive regulation of extrinsic apoptotic signaling pathway", "Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Positive regulation of fat cell differentiation", "Positive regulation of fatty acid beta oxidation", "Positive regulation of fatty acid biosynthetic process", "Positive regulation of fatty acid metabolic process", "Positive regulation of fatty acid oxidation", "Positive regulation of fatty acid transport", "Positive regulation of feeding behavior", "Positive regulation of fibroblast growth factor receptor signaling pathway", "Positive regulation of fibroblast migration", "Positive regulation of fibroblast proliferation", "Positive regulation of filopodium assembly", "Positive regulation of focal adhesion assembly", "Positive regulation of g protein coupled receptor signaling pathway", "Positive regulation of g0 to g1 transition", "Positive regulation of g1 s transition of mitotic cell cycle", "Positive regulation of gastrulation", "Positive regulation of gene expression", "Positive regulation of glial cell differentiation", "Positive regulation of glial cell migration", "Positive regulation of glial cell proliferation", "Positive regulation of gliogenesis", "Positive regulation of glucokinase activity", "Positive regulation of gluconeogenesis", "Positive regulation of glucose import", "Positive regulation of glucose metabolic process", "Positive regulation of glucose transmembrane transport", "Positive regulation of glutamate secretion", "Positive regulation of glycogen metabolic process", "Positive regulation of glycogen starch synthase activity", "Positive regulation of glycolytic process", "Positive regulation of glycoprotein metabolic process", "Positive regulation of golgi to plasma membrane protein transport", "Positive regulation of gonad development", "Positive regulation of granulocyte chemotaxis", "Positive regulation of granulocyte differentiation", "Positive regulation of growth", "Positive regulation of gtpase activity", "Positive regulation of hair follicle development", "Positive regulation of heart growth", "Positive regulation of heart rate", "Positive regulation of helicase activity", "Positive regulation of hematopoietic progenitor cell differentiation", "Positive regulation of hematopoietic stem cell proliferation", "Positive regulation of hemopoiesis", "Positive regulation of hepatocyte proliferation", "Positive regulation of heterotypic cell cell adhesion", "Positive regulation of hexokinase activity", "Positive regulation of hippo signaling", "Positive regulation of histone acetylation", "Positive regulation of histone deacetylation", "Positive regulation of histone h3 k27 methylation", "Positive regulation of histone h3 k4 methylation", "Positive regulation of histone h3 k9 acetylation", "Positive regulation of histone h3 k9 methylation", "Positive regulation of histone h4 acetylation", "Positive regulation of histone methylation", "Positive regulation of histone modification", "Positive regulation of histone phosphorylation", "Positive regulation of histone ubiquitination", "Positive regulation of homotypic cell cell adhesion", "Positive regulation of hormone biosynthetic process", "Positive regulation of hormone metabolic process", "Positive regulation of hormone secretion", "Positive regulation of humoral immune response", "Positive regulation of hydrogen peroxide metabolic process", "Positive regulation of hydrolase activity", "Positive regulation of i kappab kinase nf kappab signaling", "Positive regulation of i kappab phosphorylation", "Positive regulation of immune effector process", "Positive regulation of immune response", "Positive regulation of immune system process", "Positive regulation of immunoglobulin production", "Positive regulation of inclusion body assembly", "Positive regulation of inflammatory response", "Positive regulation of inflammatory response to antigenic stimulus", "Positive regulation of innate immune response", "Positive regulation of insulin like growth factor receptor signaling pathway", "Positive regulation of insulin secretion", "Positive regulation of insulin secretion involved in cellular response to glucose stimulus", "Positive regulation of integrin activation", "Positive regulation of integrin mediated signaling pathway", "Positive regulation of interferon alpha production", "Positive regulation of interferon beta production", "Positive regulation of interferon gamma production", "Positive regulation of interleukin 1 alpha production", "Positive regulation of interleukin 1 beta production", "Positive regulation of interleukin 1 production", "Positive regulation of interleukin 10 production", "Positive regulation of interleukin 12 production", "Positive regulation of interleukin 17 production", "Positive regulation of interleukin 18 production", "Positive regulation of interleukin 2 production", "Positive regulation of interleukin 6 production", "Positive regulation of interleukin 8 production", "Positive regulation of intracellular lipid transport", "Positive regulation of intracellular protein transport", "Positive regulation of intracellular signal transduction", "Positive regulation of intracellular steroid hormone receptor signaling pathway", "Positive regulation of intracellular transport", "Positive regulation of intrinsic apoptotic signaling pathway", "Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Positive regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Positive regulation of ion transmembrane transport", "Positive regulation of ion transport", "Positive regulation of ire1 mediated unfolded protein response", "Positive regulation of isotype switching", "Positive regulation of isotype switching to iga isotypes", "Positive regulation of isotype switching to igg isotypes", "Positive regulation of jnk cascade", "Positive regulation of jun kinase activity", "Positive regulation of keratinocyte differentiation", "Positive regulation of keratinocyte proliferation", "Positive regulation of kinase activity", "Positive regulation of lamellipodium assembly", "Positive regulation of lamellipodium morphogenesis", "Positive regulation of lamellipodium organization", "Positive regulation of leukocyte adhesion to vascular endothelial cell", "Positive regulation of leukocyte apoptotic process", "Positive regulation of leukocyte cell cell adhesion", "Positive regulation of leukocyte chemotaxis", "Positive regulation of leukocyte degranulation", "Positive regulation of leukocyte mediated immunity", "Positive regulation of leukocyte migration", "Positive regulation of leukocyte proliferation", "Positive regulation of leukocyte tethering or rolling", "Positive regulation of ligase activity", "Positive regulation of lipase activity", "Positive regulation of lipid biosynthetic process", "Positive regulation of lipid catabolic process", "Positive regulation of lipid kinase activity", "Positive regulation of lipid localization", "Positive regulation of lipid metabolic process", "Positive regulation of lipid storage", "Positive regulation of lipid transport", "Positive regulation of lipopolysaccharide mediated signaling pathway", "Positive regulation of lipoprotein particle clearance", "Positive regulation of locomotion", "Positive regulation of long term synaptic depression", "Positive regulation of long term synaptic potentiation", "Positive regulation of low density lipoprotein receptor activity", "Positive regulation of lyase activity", "Positive regulation of lymphocyte apoptotic process", "Positive regulation of lymphocyte chemotaxis", "Positive regulation of lymphocyte differentiation", "Positive regulation of lymphocyte mediated immunity", "Positive regulation of lymphocyte migration", "Positive regulation of macroautophagy", "Positive regulation of macrophage activation", "Positive regulation of macrophage chemotaxis", "Positive regulation of macrophage cytokine production", "Positive regulation of macrophage differentiation", "Positive regulation of macrophage migration", "Positive regulation of maintenance of sister chromatid cohesion", "Positive regulation of mammary gland epithelial cell proliferation", "Positive regulation of map kinase activity", "Positive regulation of mapk cascade", "Positive regulation of mast cell activation", "Positive regulation of mast cell activation involved in immune response", "Positive regulation of megakaryocyte differentiation", "Positive regulation of meiotic cell cycle", "Positive regulation of meiotic nuclear division", "Positive regulation of membrane depolarization", "Positive regulation of membrane permeability", "Positive regulation of membrane potential", "Positive regulation of membrane protein ectodomain proteolysis", "Positive regulation of mesenchymal cell proliferation", "Positive regulation of mesenchymal stem cell proliferation", "Positive regulation of metalloendopeptidase activity", "Positive regulation of metallopeptidase activity", "Positive regulation of metaphase anaphase transition of cell cycle", "Positive regulation of mhc class i biosynthetic process", "Positive regulation of mhc class ii biosynthetic process", "Positive regulation of microglial cell activation", "Positive regulation of microtubule binding", "Positive regulation of microtubule nucleation", "Positive regulation of microtubule polymerization or depolymerization", "Positive regulation of mirna catabolic process", "Positive regulation of mirna mediated gene silencing by inhibition of translation", "Positive regulation of mirna metabolic process", "Positive regulation of mirna transcription", "Positive regulation of mitochondrial calcium ion concentration", "Positive regulation of mitochondrial depolarization", "Positive regulation of mitochondrial fission", "Positive regulation of mitochondrial membrane potential", "Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Positive regulation of mitochondrial translation", "Positive regulation of mitochondrion organization", "Positive regulation of mitophagy", "Positive regulation of mitophagy in response to mitochondrial depolarization", "Positive regulation of mitotic cell cycle", "Positive regulation of mitotic cell cycle phase transition", "Positive regulation of mitotic cell cycle spindle assembly checkpoint", "Positive regulation of mitotic nuclear division", "Positive regulation of molecular function", "Positive regulation of monocyte chemotaxis", "Positive regulation of monocyte differentiation", "Positive regulation of mononuclear cell migration", "Positive regulation of monooxygenase activity", "Positive regulation of morphogenesis of an epithelium", "Positive regulation of mrna 3 end processing", "Positive regulation of mrna metabolic process", "Positive regulation of mrna processing", "Positive regulation of mrna splicing via spliceosome", "Positive regulation of multicellular organism growth", "Positive regulation of multicellular organismal process", "Positive regulation of muscle cell apoptotic process", "Positive regulation of muscle cell differentiation", "Positive regulation of muscle contraction", "Positive regulation of muscle hypertrophy", "Positive regulation of muscle tissue development", "Positive regulation of myelination", "Positive regulation of myeloid cell apoptotic process", "Positive regulation of myeloid cell differentiation", "Positive regulation of myeloid leukocyte cytokine production involved in immune response", "Positive regulation of myeloid leukocyte differentiation", "Positive regulation of myeloid leukocyte mediated immunity", "Positive regulation of myoblast differentiation", "Positive regulation of myoblast fusion", "Positive regulation of myotube differentiation", "Positive regulation of nad p h oxidase activity", "Positive regulation of natural killer cell activation", "Positive regulation of natural killer cell mediated cytotoxicity", "Positive regulation of natural killer cell mediated immunity", "Positive regulation of necrotic cell death", "Positive regulation of nervous system development", "Positive regulation of nervous system process", "Positive regulation of neural precursor cell proliferation", "Positive regulation of neuroblast proliferation", "Positive regulation of neurogenesis", "Positive regulation of neuroinflammatory response", "Positive regulation of neuron apoptotic process", "Positive regulation of neuron death", "Positive regulation of neuron differentiation", "Positive regulation of neuron migration", "Positive regulation of neuron projection arborization", "Positive regulation of neuron projection development", "Positive regulation of neuron projection regeneration", "Positive regulation of neurotransmitter secretion", "Positive regulation of neurotransmitter transport", "Positive regulation of neurotransmitter uptake", "Positive regulation of neurotrophin trk receptor signaling pathway", "Positive regulation of neutrophil migration", "Positive regulation of nf kappab transcription factor activity", "Positive regulation of nik nf kappab signaling", "Positive regulation of nitric oxide metabolic process", "Positive regulation of nitric oxide synthase activity", "Positive regulation of nitric oxide synthase biosynthetic process", "Positive regulation of nk t cell activation", "Positive regulation of nlrp3 inflammasome complex assembly", "Positive regulation of non canonical wnt signaling pathway", "Positive regulation of non motile cilium assembly", "Positive regulation of notch signaling pathway", "Positive regulation of nuclear cell cycle dna replication", "Positive regulation of nuclear division", "Positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Positive regulation of nuclease activity", "Positive regulation of nucleobase containing compound metabolic process", "Positive regulation of nucleobase containing compound transport", "Positive regulation of nucleocytoplasmic transport", "Positive regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Positive regulation of nucleotide binding oligomerization domain containing signaling pathway", "Positive regulation of nucleotide biosynthetic process", "Positive regulation of nucleotide metabolic process", "Positive regulation of oligodendrocyte differentiation", "Positive regulation of organ growth", "Positive regulation of organelle assembly", "Positive regulation of organelle organization", "Positive regulation of organic acid transport", "Positive regulation of ossification", "Positive regulation of osteoblast differentiation", "Positive regulation of osteoblast proliferation", "Positive regulation of oxidative stress induced cell death", "Positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Positive regulation of oxidative stress induced neuron death", "Positive regulation of oxidoreductase activity", "Positive regulation of p38mapk cascade", "Positive regulation of pathway restricted smad protein phosphorylation", "Positive regulation of pattern recognition receptor signaling pathway", "Positive regulation of peptidase activity", "Positive regulation of peptide secretion", "Positive regulation of peptidyl lysine acetylation", "Positive regulation of peptidyl serine phosphorylation", "Positive regulation of peptidyl threonine phosphorylation", "Positive regulation of peptidyl tyrosine phosphorylation", "Positive regulation of phagocytosis", "Positive regulation of phosphatase activity", "Positive regulation of phosphatidylinositol 3 kinase signaling", "Positive regulation of phospholipase a2 activity", "Positive regulation of phospholipase activity", "Positive regulation of phospholipid biosynthetic process", "Positive regulation of phospholipid metabolic process", "Positive regulation of phosphoprotein phosphatase activity", "Positive regulation of phosphorus metabolic process", "Positive regulation of pinocytosis", "Positive regulation of plasma membrane bounded cell projection assembly", "Positive regulation of plasminogen activation", "Positive regulation of platelet aggregation", "Positive regulation of podosome assembly", "Positive regulation of posttranscriptional gene silencing", "Positive regulation of potassium ion import across plasma membrane", "Positive regulation of potassium ion transmembrane transporter activity", "Positive regulation of potassium ion transport", "Positive regulation of production of mirnas involved in gene silencing by mirna", "Positive regulation of production of molecular mediator of immune response", "Positive regulation of programmed necrotic cell death", "Positive regulation of prostaglandin biosynthetic process", "Positive regulation of proteasomal ubiquitin dependent protein catabolic process", "Positive regulation of protein acetylation", "Positive regulation of protein autophosphorylation", "Positive regulation of protein binding", "Positive regulation of protein catabolic process", "Positive regulation of protein containing complex assembly", "Positive regulation of protein containing complex disassembly", "Positive regulation of protein deacetylation", "Positive regulation of protein dephosphorylation", "Positive regulation of protein depolymerization", "Positive regulation of protein deubiquitination", "Positive regulation of protein exit from endoplasmic reticulum", "Positive regulation of protein export from nucleus", "Positive regulation of protein glycosylation", "Positive regulation of protein import", "Positive regulation of protein k63 linked ubiquitination", "Positive regulation of protein kinase a signaling", "Positive regulation of protein kinase activity", "Positive regulation of protein kinase b signaling", "Positive regulation of protein localization", "Positive regulation of protein localization to cell cortex", "Positive regulation of protein localization to cell periphery", "Positive regulation of protein localization to cell surface", "Positive regulation of protein localization to centrosome", "Positive regulation of protein localization to cilium", "Positive regulation of protein localization to early endosome", "Positive regulation of protein localization to membrane", "Positive regulation of protein localization to nucleus", "Positive regulation of protein maturation", "Positive regulation of protein metabolic process", "Positive regulation of protein modification by small protein conjugation or removal", "Positive regulation of protein modification process", "Positive regulation of protein monoubiquitination", "Positive regulation of protein neddylation", "Positive regulation of protein phosphorylation", "Positive regulation of protein polymerization", "Positive regulation of protein polyubiquitination", "Positive regulation of protein secretion", "Positive regulation of protein serine threonine kinase activity", "Positive regulation of protein sumoylation", "Positive regulation of protein targeting to membrane", "Positive regulation of protein tyrosine kinase activity", "Positive regulation of proteolysis", "Positive regulation of proteolysis involved in cellular protein catabolic process", "Positive regulation of pseudopodium assembly", "Positive regulation of reactive oxygen species biosynthetic process", "Positive regulation of reactive oxygen species metabolic process", "Positive regulation of receptor binding", "Positive regulation of receptor catabolic process", "Positive regulation of receptor clustering", "Positive regulation of receptor internalization", "Positive regulation of receptor mediated endocytosis", "Positive regulation of receptor recycling", "Positive regulation of receptor signaling pathway via stat", "Positive regulation of regulated secretory pathway", "Positive regulation of release of cytochrome c from mitochondria", "Positive regulation of release of sequestered calcium ion into cytosol", "Positive regulation of renal sodium excretion", "Positive regulation of reproductive process", "Positive regulation of respiratory burst", "Positive regulation of response to biotic stimulus", "Positive regulation of response to cytokine stimulus", "Positive regulation of response to dna damage stimulus", "Positive regulation of response to endoplasmic reticulum stress", "Positive regulation of response to external stimulus", "Positive regulation of response to interferon gamma", "Positive regulation of response to oxidative stress", "Positive regulation of response to reactive oxygen species", "Positive regulation of response to tumor cell", "Positive regulation of response to wounding", "Positive regulation of retinoic acid receptor signaling pathway", "Positive regulation of rho protein signal transduction", "Positive regulation of rig i signaling pathway", "Positive regulation of rna binding", "Positive regulation of rna export from nucleus", "Positive regulation of rna metabolic process", "Positive regulation of rna polymerase ii transcription preinitiation complex assembly", "Positive regulation of rna splicing", "Positive regulation of rrna processing", "Positive regulation of ruffle assembly", "Positive regulation of ryanodine sensitive calcium release channel activity", "Positive regulation of secondary metabolite biosynthetic process", "Positive regulation of secretion", "Positive regulation of sequestering of calcium ion", "Positive regulation of sequestering of triglyceride", "Positive regulation of signal transduction by p53 class mediator", "Positive regulation of signaling", "Positive regulation of signaling receptor activity", "Positive regulation of sister chromatid cohesion", "Positive regulation of skeletal muscle fiber development", "Positive regulation of skeletal muscle tissue development", "Positive regulation of smad protein signal transduction", "Positive regulation of small gtpase mediated signal transduction", "Positive regulation of small molecule metabolic process", "Positive regulation of smooth muscle cell apoptotic process", "Positive regulation of smooth muscle cell differentiation", "Positive regulation of smooth muscle cell migration", "Positive regulation of smooth muscle cell proliferation", "Positive regulation of smooth muscle contraction", "Positive regulation of smoothened signaling pathway", "Positive regulation of sodium ion transmembrane transport", "Positive regulation of sodium ion transmembrane transporter activity", "Positive regulation of sodium ion transport", "Positive regulation of sphingolipid biosynthetic process", "Positive regulation of spindle assembly", "Positive regulation of sprouting angiogenesis", "Positive regulation of stem cell differentiation", "Positive regulation of stem cell proliferation", "Positive regulation of steroid biosynthetic process", "Positive regulation of steroid hormone biosynthetic process", "Positive regulation of steroid metabolic process", "Positive regulation of sterol transport", "Positive regulation of stress activated protein kinase signaling cascade", "Positive regulation of stress fiber assembly", "Positive regulation of striated muscle cell apoptotic process", "Positive regulation of striated muscle cell differentiation", "Positive regulation of striated muscle contraction", "Positive regulation of substrate adhesion dependent cell spreading", "Positive regulation of supramolecular fiber organization", "Positive regulation of synapse assembly", "Positive regulation of synapse maturation", "Positive regulation of synaptic plasticity", "Positive regulation of synaptic transmission", "Positive regulation of synaptic transmission gabaergic", "Positive regulation of synaptic transmission glutamatergic", "Positive regulation of synaptic vesicle endocytosis", "Positive regulation of synaptic vesicle exocytosis", "Positive regulation of synaptic vesicle recycling", "Positive regulation of syncytium formation by plasma membrane fusion", "Positive regulation of systemic arterial blood pressure", "Positive regulation of t cell apoptotic process", "Positive regulation of t cell cytokine production", "Positive regulation of t cell differentiation in thymus", "Positive regulation of t cell mediated cytotoxicity", "Positive regulation of t cell mediated immune response to tumor cell", "Positive regulation of t cell mediated immunity", "Positive regulation of t cell migration", "Positive regulation of t cell proliferation", "Positive regulation of t cell receptor signaling pathway", "Positive regulation of t helper 1 cell differentiation", "Positive regulation of t helper cell differentiation", "Positive regulation of tau protein kinase activity", "Positive regulation of telomerase activity", "Positive regulation of telomerase rna localization to cajal body", "Positive regulation of telomere capping", "Positive regulation of telomere maintenance", "Positive regulation of telomere maintenance via telomere lengthening", "Positive regulation of tissue remodeling", "Positive regulation of toll like receptor 3 signaling pathway", "Positive regulation of toll like receptor 9 signaling pathway", "Positive regulation of toll like receptor signaling pathway", "Positive regulation of tor signaling", "Positive regulation of torc1 signaling", "Positive regulation of transcription by rna polymerase i", "Positive regulation of transcription by rna polymerase ii", "Positive regulation of transcription by rna polymerase iii", "Positive regulation of transcription elongation from rna polymerase ii promoter", "Positive regulation of transcription from rna polymerase ii promoter in response to endoplasmic reticulum stress", "Positive regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Positive regulation of transcription from rna polymerase ii promoter in response to stress", "Positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus", "Positive regulation of transcription of notch receptor target", "Positive regulation of transcription of nucleolar large rrna by rna polymerase i", "Positive regulation of transcription regulatory region dna binding", "Positive regulation of transferase activity", "Positive regulation of transforming growth factor beta production", "Positive regulation of transforming growth factor beta1 production", "Positive regulation of translation", "Positive regulation of translation in response to endoplasmic reticulum stress", "Positive regulation of translation in response to stress", "Positive regulation of translational initiation", "Positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Positive regulation of transmembrane transport", "Positive regulation of transmission of nerve impulse", "Positive regulation of transport", "Positive regulation of transporter activity", "Positive regulation of triglyceride biosynthetic process", "Positive regulation of triglyceride catabolic process", "Positive regulation of triglyceride metabolic process", "Positive regulation of trophoblast cell migration", "Positive regulation of tumor necrosis factor mediated signaling pathway", "Positive regulation of tumor necrosis factor superfamily cytokine production", "Positive regulation of type i interferon mediated signaling pathway", "Positive regulation of type i interferon production", "Positive regulation of tyrosine phosphorylation of stat protein", "Positive regulation of ubiquitin dependent protein catabolic process", "Positive regulation of ubiquitin protein ligase activity", "Positive regulation of ubiquitin protein transferase activity", "Positive regulation of unsaturated fatty acid biosynthetic process", "Positive regulation of urine volume", "Positive regulation of vacuole organization", "Positive regulation of vascular associated smooth muscle cell apoptotic process", "Positive regulation of vascular associated smooth muscle cell differentiation", "Positive regulation of vascular associated smooth muscle cell migration", "Positive regulation of vascular associated smooth muscle cell proliferation", "Positive regulation of vascular endothelial cell proliferation", "Positive regulation of vascular endothelial growth factor production", "Positive regulation of vascular endothelial growth factor signaling pathway", "Positive regulation of vascular permeability", "Positive regulation of vasculature development", "Positive regulation of vasculogenesis", "Positive regulation of vasoconstriction", "Positive regulation of vesicle fusion", "Positive regulation of viral genome replication", "Positive regulation of viral life cycle", "Positive regulation of viral process", "Positive regulation of vitamin d receptor signaling pathway", "Positive regulation of voltage gated calcium channel activity", "Positive regulation of wnt signaling pathway", "Positive regulation of wound healing", "Positive regulation of wound healing spreading of epidermal cells", "Positive t cell selection", "Post anal tail morphogenesis", "Post chaperonin tubulin folding pathway", "Post embryonic development", "Post golgi vesicle mediated transport", "Post translational protein modification", "Postreplication repair", "Postsynapse assembly", "Postsynapse organization", "Postsynapse to nucleus signaling pathway", "Postsynaptic actin cytoskeleton organization", "Postsynaptic cytoskeleton organization", "Postsynaptic density protein 95 clustering", "Postsynaptic membrane assembly", "Postsynaptic membrane organization", "Postsynaptic modulation of chemical synaptic transmission", "Postsynaptic neurotransmitter receptor internalization", "Postsynaptic signal transduction", "Postsynaptic specialization organization", "Posttranscriptional regulation of gene expression", "Posttranslational protein targeting to endoplasmic reticulum membrane", "Posttranslational protein targeting to membrane translocation", "Potassium ion export across plasma membrane", "Potassium ion homeostasis", "Potassium ion import across plasma membrane", "Potassium ion transport", "Pre mirna processing", "Preassembly of gpi anchor in er membrane", "Prenylation", "Prepulse inhibition", "Presynapse organization", "Presynaptic active zone organization", "Presynaptic endocytosis", "Presynaptic modulation of chemical synaptic transmission", "Prevention of polyspermy", "Primary alcohol biosynthetic process", "Primary alcohol catabolic process", "Primary alcohol metabolic process", "Primary amino compound biosynthetic process", "Primary amino compound metabolic process", "Primary mirna processing", "Primitive hemopoiesis", "Pro b cell differentiation", "Process utilizing autophagic mechanism", "Production of molecular mediator involved in inflammatory response", "Production of molecular mediator of immune response", "Production of sirna involved in rna interference", "Progesterone receptor signaling pathway", "Programmed cell death", "Programmed cell death in response to reactive oxygen species", "Programmed cell death involved in cell development", "Programmed necrotic cell death", "Prolactin secretion", "Proline metabolic process", "Pronephros development", "Proprioception", "Prostaglandin transport", "Prostanoid biosynthetic process", "Prostanoid metabolic process", "Prostate gland development", "Prostate gland growth", "Prosthetic group metabolic process", "Proteasomal protein catabolic process", "Proteasome assembly", "Proteasome mediated ubiquitin dependent protein catabolic process", "Protection from natural killer cell mediated cytotoxicity", "Protection from non homologous end joining at telomere", "Protein acetylation", "Protein activation cascade", "Protein acylation", "Protein adp ribosylation", "Protein auto adp ribosylation", "Protein autophosphorylation", "Protein autoprocessing", "Protein autoubiquitination", "Protein catabolic process", "Protein catabolic process in the vacuole", "Protein complex oligomerization", "Protein containing complex disassembly", "Protein containing complex localization", "Protein containing complex organization", "Protein containing complex remodeling", "Protein de adp ribosylation", "Protein deglycosylation", "Protein demannosylation", "Protein demethylation", "Protein deneddylation", "Protein depalmitoylation", "Protein dephosphorylation", "Protein depolymerization", "Protein destabilization", "Protein desumoylation", "Protein deubiquitination involved in ubiquitin dependent protein catabolic process", "Protein dna complex assembly", "Protein dna complex disassembly", "Protein dna complex subunit organization", "Protein dna covalent cross linking repair", "Protein exit from endoplasmic reticulum", "Protein export from nucleus", "Protein folding", "Protein folding in endoplasmic reticulum", "Protein geranylgeranylation", "Protein heterooligomerization", "Protein heterotetramerization", "Protein hexamerization", "Protein homooligomerization", "Protein homotetramerization", "Protein hydroxylation", "Protein import", "Protein import into mitochondrial matrix", "Protein import into peroxisome matrix", "Protein import into peroxisome membrane", "Protein insertion into er membrane", "Protein insertion into er membrane by stop transfer membrane anchor sequence", "Protein insertion into membrane", "Protein insertion into mitochondrial inner membrane", "Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway", "Protein k11 linked ubiquitination", "Protein k27 linked ubiquitination", "Protein k29 linked ubiquitination", "Protein k48 linked deubiquitination", "Protein k48 linked ubiquitination", "Protein k6 linked ubiquitination", "Protein k63 linked deubiquitination", "Protein k63 linked ubiquitination", "Protein kinase a signaling", "Protein kinase b signaling", "Protein kinase c signaling", "Protein lipid complex assembly", "Protein lipid complex subunit organization", "Protein localization to adherens junction", "Protein localization to axon", "Protein localization to basolateral plasma membrane", "Protein localization to cell cell junction", "Protein localization to cell cortex", "Protein localization to cell junction", "Protein localization to cell periphery", "Protein localization to cell surface", "Protein localization to chromatin", "Protein localization to chromosome", "Protein localization to chromosome centromeric region", "Protein localization to chromosome telomeric region", "Protein localization to ciliary membrane", "Protein localization to cilium", "Protein localization to condensed chromosome", "Protein localization to cytoplasmic stress granule", "Protein localization to cytoskeleton", "Protein localization to early endosome", "Protein localization to endoplasmic reticulum", "Protein localization to endoplasmic reticulum exit site", "Protein localization to endosome", "Protein localization to extracellular region", "Protein localization to golgi apparatus", "Protein localization to lysosome", "Protein localization to membrane raft", "Protein localization to microtubule", "Protein localization to microtubule end", "Protein localization to microtubule organizing center", "Protein localization to mitochondrion", "Protein localization to nuclear body", "Protein localization to nuclear envelope", "Protein localization to nucleolus", "Protein localization to nucleoplasm", "Protein localization to nucleus", "Protein localization to organelle", "Protein localization to perinuclear region of cytoplasm", "Protein localization to phagophore assembly site", "Protein localization to plasma membrane", "Protein localization to postsynapse", "Protein localization to presynapse", "Protein localization to synapse", "Protein localization to vacuole", "Protein mannosylation", "Protein maturation", "Protein maturation by 4fe 4s cluster transfer", "Protein maturation by iron sulfur cluster transfer", "Protein maturation by protein folding", "Protein methylation", "Protein modification by small protein conjugation", "Protein modification by small protein conjugation or removal", "Protein modification by small protein removal", "Protein monoubiquitination", "Protein n linked glycosylation", "Protein neddylation", "Protein nitrosylation", "Protein o linked fucosylation", "Protein o linked glycosylation", "Protein o linked glycosylation via serine", "Protein o linked glycosylation via threonine", "Protein o linked mannosylation", "Protein oxidation", "Protein palmitoylation", "Protein peptidyl prolyl isomerization", "Protein poly adp ribosylation", "Protein polyglutamylation", "Protein polymerization", "Protein polyubiquitination", "Protein polyufmylation", "Protein processing", "Protein processing involved in protein targeting to mitochondrion", "Protein quality control for misfolded or incompletely synthesized proteins", "Protein refolding", "Protein repair", "Protein retention in er lumen", "Protein retention in golgi apparatus", "Protein sialylation", "Protein stabilization", "Protein sumoylation", "Protein targeting", "Protein targeting to lysosome", "Protein targeting to membrane", "Protein targeting to mitochondrion", "Protein targeting to peroxisome", "Protein targeting to vacuole", "Protein tetramerization", "Protein transmembrane import into intracellular organelle", "Protein transmembrane transport", "Protein transport along microtubule", "Protein transport to vacuole involved in ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Protein transport within lipid bilayer", "Protein trimerization", "Protein ufmylation", "Proteoglycan biosynthetic process", "Proteoglycan metabolic process", "Proteolysis", "Proton transmembrane transport", "Proton transporting two sector atpase complex assembly", "Proton transporting v type atpase complex assembly", "Protoporphyrinogen ix biosynthetic process", "Protoporphyrinogen ix metabolic process", "Proximal distal pattern formation", "Proximal distal pattern formation involved in nephron development", "Proximal tubule development", "Pseudopodium organization", "Pseudouridine synthesis", "Pteridine containing compound biosynthetic process", "Pteridine containing compound metabolic process", "Pulmonary valve development", "Pulmonary valve morphogenesis", "Purine containing compound biosynthetic process", "Purine containing compound catabolic process", "Purine containing compound metabolic process", "Purine containing compound salvage", "Purine containing compound transmembrane transport", "Purine deoxyribonucleoside metabolic process", "Purine deoxyribonucleoside monophosphate catabolic process", "Purine deoxyribonucleoside monophosphate metabolic process", "Purine deoxyribonucleoside triphosphate metabolic process", "Purine deoxyribonucleotide biosynthetic process", "Purine deoxyribonucleotide catabolic process", "Purine deoxyribonucleotide metabolic process", "Purine nucleobase biosynthetic process", "Purine nucleobase metabolic process", "Purine nucleoside biosynthetic process", "Purine nucleoside catabolic process", "Purine nucleoside diphosphate biosynthetic process", "Purine nucleoside diphosphate catabolic process", "Purine nucleoside metabolic process", "Purine nucleoside monophosphate biosynthetic process", "Purine nucleoside monophosphate catabolic process", "Purine nucleoside monophosphate metabolic process", "Purine nucleoside triphosphate catabolic process", "Purine nucleotide catabolic process", "Purine nucleotide salvage", "Purine nucleotide transport", "Purine ribonucleoside catabolic process", "Purine ribonucleoside metabolic process", "Purine ribonucleoside salvage", "Purine ribonucleotide salvage", "Purinergic nucleotide receptor signaling pathway", "Putrescine metabolic process", "Pyramidal neuron development", "Pyramidal neuron differentiation", "Pyridine containing compound biosynthetic process", "Pyridine containing compound catabolic process", "Pyridine containing compound metabolic process", "Pyridine nucleotide biosynthetic process", "Pyridine nucleotide metabolic process", "Pyrimidine containing compound biosynthetic process", "Pyrimidine containing compound catabolic process", "Pyrimidine containing compound metabolic process", "Pyrimidine containing compound salvage", "Pyrimidine containing compound transmembrane transport", "Pyrimidine deoxyribonucleoside metabolic process", "Pyrimidine deoxyribonucleoside monophosphate biosynthetic process", "Pyrimidine deoxyribonucleoside monophosphate metabolic process", "Pyrimidine deoxyribonucleoside triphosphate metabolic process", "Pyrimidine deoxyribonucleotide biosynthetic process", "Pyrimidine deoxyribonucleotide metabolic process", "Pyrimidine dimer repair", "Pyrimidine nucleobase biosynthetic process", "Pyrimidine nucleobase catabolic process", "Pyrimidine nucleobase metabolic process", "Pyrimidine nucleoside diphosphate biosynthetic process", "Pyrimidine nucleoside diphosphate metabolic process", "Pyrimidine nucleoside metabolic process", "Pyrimidine nucleoside monophosphate biosynthetic process", "Pyrimidine nucleoside monophosphate metabolic process", "Pyrimidine nucleoside transport", "Pyrimidine nucleoside triphosphate biosynthetic process", "Pyrimidine nucleoside triphosphate metabolic process", "Pyrimidine nucleotide catabolic process", "Pyrimidine nucleotide metabolic process", "Pyrimidine ribonucleoside diphosphate metabolic process", "Pyrimidine ribonucleoside monophosphate metabolic process", "Pyrimidine ribonucleoside triphosphate biosynthetic process", "Pyrimidine ribonucleoside triphosphate metabolic process", "Pyrimidine ribonucleotide biosynthetic process", "Pyrimidine ribonucleotide metabolic process", "Pyroptosis", "Pyruvate metabolic process", "Pyruvate transmembrane transport", "Pyruvate transport", "Quaternary ammonium group transport", "Quinone metabolic process", "R loop disassembly", "Rab protein signal transduction", "Rac protein signal transduction", "Radial glial cell differentiation", "Rap protein signal transduction", "Ras protein signal transduction", "Reactive nitrogen species metabolic process", "Reactive oxygen species biosynthetic process", "Reactive oxygen species metabolic process", "Receptor catabolic process", "Receptor clustering", "Receptor diffusion trapping", "Receptor internalization", "Receptor localization to synapse", "Receptor mediated endocytosis", "Receptor mediated endocytosis involved in cholesterol transport", "Receptor metabolic process", "Receptor recycling", "Receptor signaling pathway via stat", "Recognition of apoptotic cell", "Recombinational repair", "Reelin mediated signaling pathway", "Reflex", "Regeneration", "Regionalization", "Regulated exocytosis", "Regulation by virus of viral protein levels in host cell", "Regulation of 3 utr mediated mrna stabilization", "Regulation of actin cytoskeleton reorganization", "Regulation of actin filament based movement", "Regulation of actin filament based process", "Regulation of actin filament bundle assembly", "Regulation of actin filament length", "Regulation of actin filament organization", "Regulation of actin nucleation", "Regulation of action potential", "Regulation of activin receptor signaling pathway", "Regulation of actomyosin structure organization", "Regulation of acute inflammatory response", "Regulation of acute inflammatory response to antigenic stimulus", "Regulation of acyl coa biosynthetic process", "Regulation of adaptive immune response", "Regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Regulation of adenylate cyclase activity", "Regulation of adherens junction organization", "Regulation of adipose tissue development", "Regulation of aerobic respiration", "Regulation of alcohol biosynthetic process", "Regulation of alpha beta t cell activation", "Regulation of alpha beta t cell differentiation", "Regulation of alternative mrna splicing via spliceosome", "Regulation of amino acid transmembrane transport", "Regulation of amino acid transport", "Regulation of amyloid beta clearance", "Regulation of amyloid fibril formation", "Regulation of amyloid precursor protein catabolic process", "Regulation of anaphase promoting complex dependent catabolic process", "Regulation of anatomical structure morphogenesis", "Regulation of anatomical structure size", "Regulation of androgen receptor signaling pathway", "Regulation of angiotensin levels in blood", "Regulation of animal organ formation", "Regulation of animal organ morphogenesis", "Regulation of anion channel activity", "Regulation of anion transmembrane transport", "Regulation of anion transport", "Regulation of anoikis", "Regulation of antifungal innate immune response", "Regulation of antigen receptor mediated signaling pathway", "Regulation of apoptotic cell clearance", "Regulation of apoptotic dna fragmentation", "Regulation of apoptotic signaling pathway", "Regulation of appetite", "Regulation of arachidonic acid secretion", "Regulation of arp2 3 complex mediated actin nucleation", "Regulation of aspartic type endopeptidase activity involved in amyloid precursor protein catabolic process", "Regulation of aspartic type peptidase activity", "Regulation of astrocyte differentiation", "Regulation of atp biosynthetic process", "Regulation of atp dependent activity", "Regulation of atp metabolic process", "Regulation of atpase coupled calcium transmembrane transporter activity", "Regulation of atrial cardiac muscle cell membrane repolarization", "Regulation of attachment of spindle microtubules to kinetochore", "Regulation of autophagosome maturation", "Regulation of autophagy", "Regulation of autophagy of mitochondrion", "Regulation of autophagy of mitochondrion in response to mitochondrial depolarization", "Regulation of axon diameter", "Regulation of axon guidance", "Regulation of axonogenesis", "Regulation of b cell activation", "Regulation of b cell apoptotic process", "Regulation of b cell differentiation", "Regulation of b cell mediated immunity", "Regulation of b cell proliferation", "Regulation of barbed end actin filament capping", "Regulation of behavior", "Regulation of bicellular tight junction assembly", "Regulation of bile acid biosynthetic process", "Regulation of bile acid metabolic process", "Regulation of binding", "Regulation of biological process involved in symbiotic interaction", "Regulation of biomineralization", "Regulation of blood brain barrier permeability", "Regulation of blood circulation", "Regulation of blood pressure", "Regulation of bmp signaling pathway", "Regulation of body fluid levels", "Regulation of bone mineralization", "Regulation of bone remodeling", "Regulation of bone resorption", "Regulation of branching involved in lung morphogenesis", "Regulation of branching morphogenesis of a nerve", "Regulation of brown fat cell differentiation", "Regulation of calcineurin mediated signaling", "Regulation of calcium ion dependent exocytosis", "Regulation of calcium ion export across plasma membrane", "Regulation of calcium ion import", "Regulation of calcium ion transmembrane transport", "Regulation of calcium ion transmembrane transporter activity", "Regulation of calcium ion transport", "Regulation of calcium ion transport into cytosol", "Regulation of calcium mediated signaling", "Regulation of camp dependent protein kinase activity", "Regulation of camp mediated signaling", "Regulation of canonical wnt signaling pathway", "Regulation of carbohydrate biosynthetic process", "Regulation of carbohydrate catabolic process", "Regulation of carbohydrate metabolic process", "Regulation of cardiac conduction", "Regulation of cardiac muscle adaptation", "Regulation of cardiac muscle cell action potential", "Regulation of cardiac muscle cell action potential involved in regulation of contraction", "Regulation of cardiac muscle cell membrane potential", "Regulation of cardiac muscle cell membrane repolarization", "Regulation of cardiac muscle cell proliferation", "Regulation of cardiac muscle contraction", "Regulation of cardiac muscle contraction by calcium ion signaling", "Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion", "Regulation of cardioblast differentiation", "Regulation of cardiocyte differentiation", "Regulation of cartilage development", "Regulation of catabolic process", "Regulation of catecholamine metabolic process", "Regulation of cation channel activity", "Regulation of cation transmembrane transport", "Regulation of caveolin mediated endocytosis", "Regulation of cd4 positive alpha beta t cell activation", "Regulation of cd4 positive alpha beta t cell differentiation", "Regulation of cd40 signaling pathway", "Regulation of cd8 positive alpha beta t cell activation", "Regulation of cd8 positive alpha beta t cell differentiation", "Regulation of cdc42 protein signal transduction", "Regulation of cell activation", "Regulation of cell adhesion", "Regulation of cell adhesion mediated by integrin", "Regulation of cell aging", "Regulation of cell cell adhesion", "Regulation of cell cell adhesion mediated by cadherin", "Regulation of cell cell adhesion mediated by integrin", "Regulation of cell communication by electrical coupling", "Regulation of cell communication by electrical coupling involved in cardiac conduction", "Regulation of cell cycle", "Regulation of cell cycle checkpoint", "Regulation of cell cycle g1 s phase transition", "Regulation of cell cycle g2 m phase transition", "Regulation of cell cycle phase transition", "Regulation of cell cycle process", "Regulation of cell death", "Regulation of cell development", "Regulation of cell differentiation", "Regulation of cell division", "Regulation of cell growth involved in cardiac muscle cell development", "Regulation of cell junction assembly", "Regulation of cell killing", "Regulation of cell matrix adhesion", "Regulation of cell maturation", "Regulation of cell migration involved in sprouting angiogenesis", "Regulation of cell morphogenesis", "Regulation of cell morphogenesis involved in differentiation", "Regulation of cell population proliferation", "Regulation of cell projection assembly", "Regulation of cell projection organization", "Regulation of cell projection size", "Regulation of cell shape", "Regulation of cell size", "Regulation of cell substrate adhesion", "Regulation of cell substrate junction organization", "Regulation of cellular amide metabolic process", "Regulation of cellular amine metabolic process", "Regulation of cellular amino acid metabolic process", "Regulation of cellular carbohydrate catabolic process", "Regulation of cellular carbohydrate metabolic process", "Regulation of cellular component biogenesis", "Regulation of cellular component movement", "Regulation of cellular component size", "Regulation of cellular extravasation", "Regulation of cellular ketone metabolic process", "Regulation of cellular localization", "Regulation of cellular macromolecule biosynthetic process", "Regulation of cellular ph", "Regulation of cellular ph reduction", "Regulation of cellular protein catabolic process", "Regulation of cellular respiration", "Regulation of cellular response to growth factor stimulus", "Regulation of cellular response to heat", "Regulation of cellular response to hypoxia", "Regulation of cellular response to insulin stimulus", "Regulation of cellular response to osmotic stress", "Regulation of cellular response to stress", "Regulation of cellular response to transforming growth factor beta stimulus", "Regulation of cellular response to vascular endothelial growth factor stimulus", "Regulation of centriole replication", "Regulation of centrosome cycle", "Regulation of chaperone mediated autophagy", "Regulation of chemokine mediated signaling pathway", "Regulation of chemotaxis", "Regulation of chloride transport", "Regulation of cholesterol biosynthetic process", "Regulation of cholesterol efflux", "Regulation of cholesterol esterification", "Regulation of cholesterol metabolic process", "Regulation of chondrocyte differentiation", "Regulation of chromatin assembly", "Regulation of chromatin assembly or disassembly", "Regulation of chromatin binding", "Regulation of chromatin organization", "Regulation of chromosome condensation", "Regulation of chromosome organization", "Regulation of chromosome segregation", "Regulation of chromosome separation", "Regulation of cilium assembly", "Regulation of cilium beat frequency", "Regulation of cilium beat frequency involved in ciliary motility", "Regulation of cilium dependent cell motility", "Regulation of cilium movement", "Regulation of circadian rhythm", "Regulation of clathrin dependent endocytosis", "Regulation of coagulation", "Regulation of collagen fibril organization", "Regulation of collagen metabolic process", "Regulation of collateral sprouting", "Regulation of complement activation", "Regulation of complement dependent cytotoxicity", "Regulation of connective tissue replacement", "Regulation of core promoter binding", "Regulation of cyclase activity", "Regulation of cyclic nucleotide phosphodiesterase activity", "Regulation of cyclin dependent protein kinase activity", "Regulation of cysteine type endopeptidase activity", "Regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis", "Regulation of cytokinesis", "Regulation of cytoplasmic mrna processing body assembly", "Regulation of cytoplasmic translation", "Regulation of cytoplasmic translational elongation", "Regulation of cytoplasmic translational initiation", "Regulation of cytoplasmic transport", "Regulation of cytoskeleton organization", "Regulation of cytosolic calcium ion concentration", "Regulation of deacetylase activity", "Regulation of defense response", "Regulation of defense response to bacterium", "Regulation of defense response to fungus", "Regulation of defense response to virus", "Regulation of defense response to virus by host", "Regulation of delayed rectifier potassium channel activity", "Regulation of dendrite development", "Regulation of dendrite extension", "Regulation of dendrite morphogenesis", "Regulation of dendritic cell chemotaxis", "Regulation of dendritic cell differentiation", "Regulation of dendritic spine development", "Regulation of dendritic spine maintenance", "Regulation of dendritic spine morphogenesis", "Regulation of deoxyribonuclease activity", "Regulation of dephosphorylation", "Regulation of development heterochronic", "Regulation of developmental growth", "Regulation of digestive system process", "Regulation of dna binding", "Regulation of dna binding transcription factor activity", "Regulation of dna biosynthetic process", "Regulation of dna catabolic process", "Regulation of dna damage checkpoint", "Regulation of dna damage response signal transduction by p53 class mediator", "Regulation of dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator", "Regulation of dna demethylation", "Regulation of dna dependent dna replication", "Regulation of dna dependent dna replication initiation", "Regulation of dna directed dna polymerase activity", "Regulation of dna duplex unwinding", "Regulation of dna helicase activity", "Regulation of dna ligation", "Regulation of dna metabolic process", "Regulation of dna methylation", "Regulation of dna methylation dependent heterochromatin assembly", "Regulation of dna primase activity", "Regulation of dna recombination", "Regulation of dna repair", "Regulation of dna replication", "Regulation of dna strand elongation", "Regulation of dna templated transcription elongation", "Regulation of dna templated transcription in response to stress", "Regulation of dna templated transcription initiation", "Regulation of dna topoisomerase atp hydrolyzing activity", "Regulation of dopamine receptor signaling pathway", "Regulation of dopamine uptake involved in synaptic transmission", "Regulation of dopaminergic neuron differentiation", "Regulation of double strand break repair", "Regulation of double strand break repair via homologous recombination", "Regulation of double strand break repair via nonhomologous end joining", "Regulation of early endosome to late endosome transport", "Regulation of electron transfer activity", "Regulation of embryonic development", "Regulation of endocrine process", "Regulation of endocytic recycling", "Regulation of endocytosis", "Regulation of endodeoxyribonuclease activity", "Regulation of endodermal cell differentiation", "Regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Regulation of endoplasmic reticulum tubular network organization", "Regulation of endoplasmic reticulum unfolded protein response", "Regulation of endothelial cell chemotaxis", "Regulation of endothelial cell development", "Regulation of endothelial cell differentiation", "Regulation of endothelial cell migration", "Regulation of entry of bacterium into host cell", "Regulation of epidermal growth factor activated receptor activity", "Regulation of epidermis development", "Regulation of epithelial cell apoptotic process", "Regulation of epithelial cell differentiation", "Regulation of epithelial cell differentiation involved in kidney development", "Regulation of epithelial cell migration", "Regulation of epithelial cell proliferation involved in lung morphogenesis", "Regulation of epithelial to mesenchymal transition", "Regulation of er associated ubiquitin dependent protein catabolic process", "Regulation of er to golgi vesicle mediated transport", "Regulation of erad pathway", "Regulation of erbb signaling pathway", "Regulation of erythrocyte differentiation", "Regulation of establishment of planar polarity", "Regulation of establishment of protein localization", "Regulation of establishment of protein localization to chromosome", "Regulation of establishment of protein localization to mitochondrion", "Regulation of establishment or maintenance of cell polarity", "Regulation of excretion", "Regulation of execution phase of apoptosis", "Regulation of exit from mitosis", "Regulation of exocytosis", "Regulation of exosomal secretion", "Regulation of extent of cell growth", "Regulation of extracellular matrix assembly", "Regulation of extracellular matrix disassembly", "Regulation of extracellular matrix organization", "Regulation of extrinsic apoptotic signaling pathway", "Regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Regulation of fat cell differentiation", "Regulation of fat cell proliferation", "Regulation of fatty acid beta oxidation", "Regulation of fatty acid biosynthetic process", "Regulation of fatty acid metabolic process", "Regulation of fatty acid oxidation", "Regulation of fatty acid transport", "Regulation of fc gamma receptor signaling pathway involved in phagocytosis", "Regulation of fc receptor mediated stimulatory signaling pathway", "Regulation of feeding behavior", "Regulation of fertilization", "Regulation of fibroblast growth factor receptor signaling pathway", "Regulation of fibroblast migration", "Regulation of filopodium assembly", "Regulation of focal adhesion disassembly", "Regulation of g protein coupled receptor signaling pathway", "Regulation of g0 to g1 transition", "Regulation of gastrulation", "Regulation of gene expression by genomic imprinting", "Regulation of gene expression epigenetic", "Regulation of gene silencing by rna", "Regulation of generation of precursor metabolites and energy", "Regulation of genetic imprinting", "Regulation of germ cell proliferation", "Regulation of germinal center formation", "Regulation of glial cell apoptotic process", "Regulation of glial cell differentiation", "Regulation of glial cell migration", "Regulation of glial cell proliferation", "Regulation of gliogenesis", "Regulation of glucagon secretion", "Regulation of glucan biosynthetic process", "Regulation of glucocorticoid biosynthetic process", "Regulation of glucocorticoid metabolic process", "Regulation of glucocorticoid receptor signaling pathway", "Regulation of glucocorticoid secretion", "Regulation of gluconeogenesis", "Regulation of glucose import", "Regulation of glucose metabolic process", "Regulation of glucose transmembrane transport", "Regulation of glucosylceramidase activity", "Regulation of glutamate receptor clustering", "Regulation of glutamate secretion", "Regulation of glutamine family amino acid metabolic process", "Regulation of glycogen catabolic process", "Regulation of glycogen metabolic process", "Regulation of glycogen starch synthase activity", "Regulation of glycolytic process", "Regulation of glycoprotein metabolic process", "Regulation of golgi organization", "Regulation of golgi to plasma membrane protein transport", "Regulation of gonad development", "Regulation of granulocyte chemotaxis", "Regulation of granulocyte differentiation", "Regulation of growth", "Regulation of gtp binding", "Regulation of gtpase activity", "Regulation of guanyl nucleotide exchange factor activity", "Regulation of hair cycle", "Regulation of hair follicle development", "Regulation of heart contraction", "Regulation of heart growth", "Regulation of heart rate", "Regulation of heart rate by cardiac conduction", "Regulation of heart rate by chemical signal", "Regulation of helicase activity", "Regulation of hematopoietic progenitor cell differentiation", "Regulation of hematopoietic stem cell differentiation", "Regulation of hematopoietic stem cell proliferation", "Regulation of hemoglobin biosynthetic process", "Regulation of hemopoiesis", "Regulation of hepatic stellate cell activation", "Regulation of hepatocyte proliferation", "Regulation of heterotypic cell cell adhesion", "Regulation of hexokinase activity", "Regulation of high voltage gated calcium channel activity", "Regulation of hippo signaling", "Regulation of histamine secretion by mast cell", "Regulation of histone deacetylase activity", "Regulation of histone deacetylation", "Regulation of histone h2b ubiquitination", "Regulation of histone h3 k14 acetylation", "Regulation of histone h3 k27 methylation", "Regulation of histone h3 k36 methylation", "Regulation of histone h3 k4 methylation", "Regulation of histone h3 k9 methylation", "Regulation of histone h3 k9 trimethylation", "Regulation of histone h4 acetylation", "Regulation of histone h4 k16 acetylation", "Regulation of histone methylation", "Regulation of histone modification", "Regulation of histone phosphorylation", "Regulation of histone ubiquitination", "Regulation of homotypic cell cell adhesion", "Regulation of hormone biosynthetic process", "Regulation of hormone levels", "Regulation of hormone metabolic process", "Regulation of hormone secretion", "Regulation of humoral immune response", "Regulation of hyaluronan biosynthetic process", "Regulation of hydrogen peroxide biosynthetic process", "Regulation of hydrogen peroxide mediated programmed cell death", "Regulation of hydrogen peroxide metabolic process", "Regulation of hydrolase activity", "Regulation of i kappab phosphorylation", "Regulation of icosanoid secretion", "Regulation of immune effector process", "Regulation of immune response", "Regulation of immune system process", "Regulation of immunoglobulin production", "Regulation of inclusion body assembly", "Regulation of inflammatory response", "Regulation of inflammatory response to antigenic stimulus", "Regulation of innate immune response", "Regulation of inositol 1 4 5 trisphosphate sensitive calcium release channel activity", "Regulation of insulin like growth factor receptor signaling pathway", "Regulation of insulin receptor signaling pathway", "Regulation of insulin secretion", "Regulation of insulin secretion involved in cellular response to glucose stimulus", "Regulation of integrin activation", "Regulation of integrin mediated signaling pathway", "Regulation of interleukin 1 mediated signaling pathway", "Regulation of interleukin 6 mediated signaling pathway", "Regulation of intestinal absorption", "Regulation of intracellular estrogen receptor signaling pathway", "Regulation of intracellular lipid transport", "Regulation of intracellular protein transport", "Regulation of intracellular signal transduction", "Regulation of intracellular steroid hormone receptor signaling pathway", "Regulation of intracellular transport", "Regulation of intrinsic apoptotic signaling pathway", "Regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Regulation of inward rectifier potassium channel activity", "Regulation of ion transmembrane transport", "Regulation of ion transport", "Regulation of ire1 mediated unfolded protein response", "Regulation of iron ion transmembrane transport", "Regulation of iron ion transport", "Regulation of isomerase activity", "Regulation of isotype switching", "Regulation of jnk cascade", "Regulation of jun kinase activity", "Regulation of keratinocyte differentiation", "Regulation of keratinocyte migration", "Regulation of keratinocyte proliferation", "Regulation of kidney development", "Regulation of l glutamate import across plasma membrane", "Regulation of lamellipodium assembly", "Regulation of lamellipodium morphogenesis", "Regulation of lamellipodium organization", "Regulation of leukocyte adhesion to vascular endothelial cell", "Regulation of leukocyte apoptotic process", "Regulation of leukocyte chemotaxis", "Regulation of leukocyte degranulation", "Regulation of leukocyte differentiation", "Regulation of leukocyte mediated cytotoxicity", "Regulation of leukocyte mediated immunity", "Regulation of leukocyte migration", "Regulation of leukocyte proliferation", "Regulation of leukocyte tethering or rolling", "Regulation of ligase activity", "Regulation of lipase activity", "Regulation of lipid biosynthetic process", "Regulation of lipid catabolic process", "Regulation of lipid kinase activity", "Regulation of lipid localization", "Regulation of lipid metabolic process", "Regulation of lipid storage", "Regulation of lipid transport", "Regulation of lipid transporter activity", "Regulation of lipophagy", "Regulation of lipopolysaccharide mediated signaling pathway", "Regulation of lipoprotein metabolic process", "Regulation of lipoprotein particle clearance", "Regulation of locomotion involved in locomotory behavior", "Regulation of long chain fatty acid import across plasma membrane", "Regulation of long chain fatty acid import into cell", "Regulation of long term neuronal synaptic plasticity", "Regulation of long term synaptic depression", "Regulation of long term synaptic potentiation", "Regulation of low density lipoprotein particle clearance", "Regulation of lyase activity", "Regulation of lymphocyte activation", "Regulation of lymphocyte apoptotic process", "Regulation of lymphocyte chemotaxis", "Regulation of lymphocyte differentiation", "Regulation of lymphocyte mediated immunity", "Regulation of lymphocyte migration", "Regulation of lymphoid progenitor cell differentiation", "Regulation of lysosomal lumen ph", "Regulation of lysosomal protein catabolic process", "Regulation of lysosome organization", "Regulation of macroautophagy", "Regulation of macrophage activation", "Regulation of macrophage apoptotic process", "Regulation of macrophage chemotaxis", "Regulation of macrophage derived foam cell differentiation", "Regulation of macrophage differentiation", "Regulation of macrophage migration", "Regulation of macrophage proliferation", "Regulation of maintenance of sister chromatid cohesion", "Regulation of male gonad development", "Regulation of mammary gland epithelial cell proliferation", "Regulation of map kinase activity", "Regulation of mast cell activation", "Regulation of mast cell activation involved in immune response", "Regulation of matrix metallopeptidase secretion", "Regulation of mda 5 signaling pathway", "Regulation of megakaryocyte differentiation", "Regulation of meiotic cell cycle", "Regulation of meiotic cell cycle phase transition", "Regulation of meiotic nuclear division", "Regulation of membrane depolarization", "Regulation of membrane depolarization during action potential", "Regulation of membrane depolarization during cardiac muscle cell action potential", "Regulation of membrane invagination", "Regulation of membrane lipid distribution", "Regulation of membrane permeability", "Regulation of membrane potential", "Regulation of membrane protein ectodomain proteolysis", "Regulation of membrane repolarization", "Regulation of membrane repolarization during action potential", "Regulation of membrane repolarization during cardiac muscle cell action potential", "Regulation of membrane tubulation", "Regulation of mesenchymal cell proliferation", "Regulation of mesenchymal stem cell differentiation", "Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis", "Regulation of mesoderm development", "Regulation of metal ion transport", "Regulation of metalloendopeptidase activity", "Regulation of metallopeptidase activity", "Regulation of metanephros development", "Regulation of metaphase plate congression", "Regulation of microglial cell activation", "Regulation of microtubule based movement", "Regulation of microtubule based process", "Regulation of microtubule binding", "Regulation of microtubule cytoskeleton organization", "Regulation of microtubule depolymerization", "Regulation of microtubule nucleation", "Regulation of microtubule polymerization", "Regulation of microtubule polymerization or depolymerization", "Regulation of microvillus assembly", "Regulation of microvillus length", "Regulation of microvillus organization", "Regulation of midbrain dopaminergic neuron differentiation", "Regulation of mirna catabolic process", "Regulation of mirna metabolic process", "Regulation of mirna transcription", "Regulation of mitochondrial atp synthesis coupled electron transport", "Regulation of mitochondrial dna replication", "Regulation of mitochondrial electron transport nadh to ubiquinone", "Regulation of mitochondrial fission", "Regulation of mitochondrial fusion", "Regulation of mitochondrial gene expression", "Regulation of mitochondrial membrane permeability", "Regulation of mitochondrial membrane permeability involved in apoptotic process", "Regulation of mitochondrial membrane potential", "Regulation of mitochondrial mrna stability", "Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Regulation of mitochondrial rna catabolic process", "Regulation of mitochondrion organization", "Regulation of mitophagy", "Regulation of mitotic cell cycle", "Regulation of mitotic cell cycle phase transition", "Regulation of mitotic cell cycle spindle assembly checkpoint", "Regulation of mitotic centrosome separation", "Regulation of mitotic cytokinesis", "Regulation of mitotic nuclear division", "Regulation of mitotic recombination", "Regulation of mitotic sister chromatid segregation", "Regulation of mitotic spindle assembly", "Regulation of modification of postsynaptic structure", "Regulation of modification of synaptic structure", "Regulation of monocyte chemotaxis", "Regulation of monocyte differentiation", "Regulation of monocyte extravasation", "Regulation of mononuclear cell migration", "Regulation of monooxygenase activity", "Regulation of morphogenesis of a branching structure", "Regulation of morphogenesis of an epithelium", "Regulation of motor neuron apoptotic process", "Regulation of mrna 3 end processing", "Regulation of mrna binding", "Regulation of mrna catabolic process", "Regulation of mrna export from nucleus", "Regulation of mrna metabolic process", "Regulation of mrna polyadenylation", "Regulation of mrna processing", "Regulation of mrna splicing via spliceosome", "Regulation of mucus secretion", "Regulation of multicellular organism growth", "Regulation of multicellular organismal development", "Regulation of muscle adaptation", "Regulation of muscle cell differentiation", "Regulation of muscle contraction", "Regulation of muscle hypertrophy", "Regulation of muscle organ development", "Regulation of muscle system process", "Regulation of myelination", "Regulation of myeloid cell apoptotic process", "Regulation of myeloid cell differentiation", "Regulation of myeloid leukocyte differentiation", "Regulation of myeloid leukocyte mediated immunity", "Regulation of myoblast differentiation", "Regulation of myoblast fusion", "Regulation of myosin light chain phosphatase activity", "Regulation of myotube differentiation", "Regulation of nad p h oxidase activity", "Regulation of nadp metabolic process", "Regulation of natural killer cell activation", "Regulation of natural killer cell mediated immunity", "Regulation of necrotic cell death", "Regulation of nervous system development", "Regulation of nervous system process", "Regulation of neural precursor cell proliferation", "Regulation of neuroblast proliferation", "Regulation of neurogenesis", "Regulation of neuromuscular junction development", "Regulation of neuron differentiation", "Regulation of neuron migration", "Regulation of neuron projection arborization", "Regulation of neuron projection development", "Regulation of neuron projection regeneration", "Regulation of neuronal action potential", "Regulation of neuronal synaptic plasticity", "Regulation of neurotransmitter levels", "Regulation of neurotransmitter receptor activity", "Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane", "Regulation of neurotransmitter transport", "Regulation of neurotransmitter uptake", "Regulation of neurotrophin trk receptor signaling pathway", "Regulation of neutrophil chemotaxis", "Regulation of neutrophil migration", "Regulation of nik nf kappab signaling", "Regulation of nitric oxide mediated signal transduction", "Regulation of nitric oxide metabolic process", "Regulation of nitric oxide synthase activity", "Regulation of nk t cell activation", "Regulation of nk t cell differentiation", "Regulation of nmda receptor activity", "Regulation of non canonical wnt signaling pathway", "Regulation of non motile cilium assembly", "Regulation of notch signaling pathway", "Regulation of nuclear cell cycle dna replication", "Regulation of nuclear division", "Regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Regulation of nuclear transcribed mrna poly a tail shortening", "Regulation of nuclease activity", "Regulation of nucleobase containing compound transport", "Regulation of nucleocytoplasmic transport", "Regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Regulation of nucleotide binding oligomerization domain containing signaling pathway", "Regulation of nucleotide biosynthetic process", "Regulation of nucleotide metabolic process", "Regulation of oligodendrocyte differentiation", "Regulation of oocyte maturation", "Regulation of organ growth", "Regulation of organelle assembly", "Regulation of organelle organization", "Regulation of organelle transport along microtubule", "Regulation of organic acid transport", "Regulation of ossification", "Regulation of osteoblast differentiation", "Regulation of osteoblast proliferation", "Regulation of osteoclast differentiation", "Regulation of oxidative phosphorylation", "Regulation of oxidative stress induced cell death", "Regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Regulation of oxidoreductase activity", "Regulation of p38mapk cascade", "Regulation of pattern recognition receptor signaling pathway", "Regulation of penile erection", "Regulation of peptidase activity", "Regulation of peptide transport", "Regulation of peptidyl cysteine s nitrosylation", "Regulation of peptidyl lysine acetylation", "Regulation of peptidyl serine phosphorylation", "Regulation of peptidyl serine phosphorylation of stat protein", "Regulation of peptidyl threonine phosphorylation", "Regulation of peptidyl tyrosine phosphorylation", "Regulation of perk mediated unfolded protein response", "Regulation of peroxisome proliferator activated receptor signaling pathway", "Regulation of ph", "Regulation of phagocytosis", "Regulation of phenotypic switching", "Regulation of phosphatase activity", "Regulation of phosphatidylcholine biosynthetic process", "Regulation of phosphatidylcholine metabolic process", "Regulation of phosphatidylinositol 3 kinase activity", "Regulation of phosphatidylinositol 3 kinase signaling", "Regulation of phospholipase a2 activity", "Regulation of phospholipase activity", "Regulation of phospholipase c activity", "Regulation of phospholipid biosynthetic process", "Regulation of phospholipid catabolic process", "Regulation of phospholipid metabolic process", "Regulation of phospholipid translocation", "Regulation of phospholipid transport", "Regulation of phosphoprotein phosphatase activity", "Regulation of phosphorus metabolic process", "Regulation of pigmentation", "Regulation of pinocytosis", "Regulation of plasma lipoprotein particle levels", "Regulation of plasma membrane organization", "Regulation of plasminogen activation", "Regulation of platelet activation", "Regulation of platelet aggregation", "Regulation of platelet derived growth factor receptor signaling pathway", "Regulation of podosome assembly", "Regulation of polysaccharide metabolic process", "Regulation of post translational protein modification", "Regulation of postsynapse organization", "Regulation of postsynaptic cytosolic calcium ion concentration", "Regulation of postsynaptic density organization", "Regulation of postsynaptic membrane neurotransmitter receptor levels", "Regulation of postsynaptic membrane potential", "Regulation of postsynaptic neurotransmitter receptor activity", "Regulation of postsynaptic neurotransmitter receptor internalization", "Regulation of potassium ion export across plasma membrane", "Regulation of potassium ion import", "Regulation of potassium ion transmembrane transporter activity", "Regulation of potassium ion transport", "Regulation of presynapse organization", "Regulation of presynaptic cytosolic calcium ion concentration", "Regulation of pro b cell differentiation", "Regulation of production of molecular mediator of immune response", "Regulation of production of small rna involved in gene silencing by rna", "Regulation of programmed necrotic cell death", "Regulation of prostaglandin secretion", "Regulation of proteasomal protein catabolic process", "Regulation of proteasomal ubiquitin dependent protein catabolic process", "Regulation of protein acetylation", "Regulation of protein adp ribosylation", "Regulation of protein autophosphorylation", "Regulation of protein autoubiquitination", "Regulation of protein binding", "Regulation of protein catabolic process", "Regulation of protein catabolic process in the vacuole", "Regulation of protein complex stability", "Regulation of protein containing complex assembly", "Regulation of protein containing complex disassembly", "Regulation of protein deacetylation", "Regulation of protein dephosphorylation", "Regulation of protein depolymerization", "Regulation of protein deubiquitination", "Regulation of protein exit from endoplasmic reticulum", "Regulation of protein export from nucleus", "Regulation of protein folding", "Regulation of protein glycosylation", "Regulation of protein import", "Regulation of protein k63 linked ubiquitination", "Regulation of protein kinase a signaling", "Regulation of protein kinase activity", "Regulation of protein kinase c signaling", "Regulation of protein lipidation", "Regulation of protein localization", "Regulation of protein localization to cell cortex", "Regulation of protein localization to cell periphery", "Regulation of protein localization to cell surface", "Regulation of protein localization to centrosome", "Regulation of protein localization to chromatin", "Regulation of protein localization to chromosome telomeric region", "Regulation of protein localization to cilium", "Regulation of protein localization to endosome", "Regulation of protein localization to membrane", "Regulation of protein localization to nucleolus", "Regulation of protein localization to nucleus", "Regulation of protein localization to plasma membrane", "Regulation of protein localization to synapse", "Regulation of protein maturation", "Regulation of protein modification by small protein conjugation or removal", "Regulation of protein modification process", "Regulation of protein monoubiquitination", "Regulation of protein neddylation", "Regulation of protein phosphorylation", "Regulation of protein polymerization", "Regulation of protein polyubiquitination", "Regulation of protein secretion", "Regulation of protein serine threonine kinase activity", "Regulation of protein stability", "Regulation of protein sumoylation", "Regulation of protein targeting", "Regulation of protein targeting to membrane", "Regulation of protein tyrosine kinase activity", "Regulation of protein tyrosine phosphatase activity", "Regulation of proteolysis", "Regulation of proton transport", "Regulation of rac protein signal transduction", "Regulation of ras protein signal transduction", "Regulation of reactive oxygen species biosynthetic process", "Regulation of reactive oxygen species metabolic process", "Regulation of receptor binding", "Regulation of receptor catabolic process", "Regulation of receptor clustering", "Regulation of receptor internalization", "Regulation of receptor localization to synapse", "Regulation of receptor mediated endocytosis", "Regulation of receptor mediated endocytosis involved in cholesterol transport", "Regulation of receptor recycling", "Regulation of receptor signaling pathway via stat", "Regulation of regulated secretory pathway", "Regulation of relaxation of cardiac muscle", "Regulation of relaxation of muscle", "Regulation of release of cytochrome c from mitochondria", "Regulation of release of sequestered calcium ion into cytosol", "Regulation of removal of superoxide radicals", "Regulation of renal system process", "Regulation of reproductive process", "Regulation of respiratory burst", "Regulation of respiratory gaseous exchange", "Regulation of respiratory gaseous exchange by nervous system process", "Regulation of respiratory system process", "Regulation of response to biotic stimulus", "Regulation of response to cytokine stimulus", "Regulation of response to dna damage stimulus", "Regulation of response to endoplasmic reticulum stress", "Regulation of response to external stimulus", "Regulation of response to extracellular stimulus", "Regulation of response to food", "Regulation of response to interferon gamma", "Regulation of response to osmotic stress", "Regulation of response to oxidative stress", "Regulation of response to reactive oxygen species", "Regulation of response to stress", "Regulation of response to tumor cell", "Regulation of response to wounding", "Regulation of retinal ganglion cell axon guidance", "Regulation of retinoic acid receptor signaling pathway", "Regulation of retrograde protein transport er to cytosol", "Regulation of retrograde transport endosome to golgi", "Regulation of rho dependent protein serine threonine kinase activity", "Regulation of rho protein signal transduction", "Regulation of rhodopsin mediated signaling pathway", "Regulation of ribonuclease activity", "Regulation of ribosome biogenesis", "Regulation of rig i signaling pathway", "Regulation of rna binding", "Regulation of rna export from nucleus", "Regulation of rna polymerase ii regulatory region sequence specific dna binding", "Regulation of rna polymerase ii transcription preinitiation complex assembly", "Regulation of rna splicing", "Regulation of rrna processing", "Regulation of ruffle assembly", "Regulation of ryanodine sensitive calcium release channel activity", "Regulation of secondary heart field cardioblast proliferation", "Regulation of secondary metabolic process", "Regulation of secretion", "Regulation of sequestering of triglyceride", "Regulation of sequestering of zinc ion", "Regulation of short term neuronal synaptic plasticity", "Regulation of signal transduction by p53 class mediator", "Regulation of signaling receptor activity", "Regulation of sister chromatid cohesion", "Regulation of skeletal muscle adaptation", "Regulation of skeletal muscle cell differentiation", "Regulation of skeletal muscle contraction", "Regulation of skeletal muscle contraction by calcium ion signaling", "Regulation of skeletal muscle fiber development", "Regulation of skeletal muscle tissue development", "Regulation of smad protein complex assembly", "Regulation of smad protein signal transduction", "Regulation of small gtpase mediated signal transduction", "Regulation of small molecule metabolic process", "Regulation of smooth muscle cell chemotaxis", "Regulation of smooth muscle cell differentiation", "Regulation of smooth muscle contraction", "Regulation of smoothened signaling pathway", "Regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Regulation of snrna transcription by rna polymerase ii", "Regulation of sodium ion transmembrane transport", "Regulation of sodium ion transport", "Regulation of sodium proton antiporter activity", "Regulation of somatic stem cell population maintenance", "Regulation of sphingolipid biosynthetic process", "Regulation of spindle assembly", "Regulation of spindle organization", "Regulation of spontaneous synaptic transmission", "Regulation of sprouting angiogenesis", "Regulation of srebp signaling pathway", "Regulation of stem cell differentiation", "Regulation of stem cell population maintenance", "Regulation of stem cell proliferation", "Regulation of steroid biosynthetic process", "Regulation of steroid hormone biosynthetic process", "Regulation of steroid hormone secretion", "Regulation of steroid metabolic process", "Regulation of sterol transport", "Regulation of stress activated protein kinase signaling cascade", "Regulation of stress granule assembly", "Regulation of striated muscle cell differentiation", "Regulation of striated muscle contraction", "Regulation of substrate adhesion dependent cell spreading", "Regulation of sulfur metabolic process", "Regulation of superoxide anion generation", "Regulation of superoxide dismutase activity", "Regulation of superoxide metabolic process", "Regulation of supramolecular fiber organization", "Regulation of synapse assembly", "Regulation of synapse maturation", "Regulation of synapse structural plasticity", "Regulation of synapse structure or activity", "Regulation of synaptic plasticity", "Regulation of synaptic transmission dopaminergic", "Regulation of synaptic transmission gabaergic", "Regulation of synaptic transmission glutamatergic", "Regulation of synaptic vesicle clustering", "Regulation of synaptic vesicle cycle", "Regulation of synaptic vesicle endocytosis", "Regulation of synaptic vesicle exocytosis", "Regulation of synaptic vesicle priming", "Regulation of synaptic vesicle recycling", "Regulation of syncytium formation by plasma membrane fusion", "Regulation of system process", "Regulation of systemic arterial blood pressure", "Regulation of systemic arterial blood pressure by circulatory renin angiotensin", "Regulation of systemic arterial blood pressure by endothelin", "Regulation of systemic arterial blood pressure by hormone", "Regulation of systemic arterial blood pressure by norepinephrine epinephrine", "Regulation of systemic arterial blood pressure by renin angiotensin", "Regulation of systemic arterial blood pressure mediated by a chemical signal", "Regulation of t cell activation", "Regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell", "Regulation of t cell apoptotic process", "Regulation of t cell chemotaxis", "Regulation of t cell differentiation", "Regulation of t cell differentiation in thymus", "Regulation of t cell mediated cytotoxicity", "Regulation of t cell mediated immune response to tumor cell", "Regulation of t cell mediated immunity", "Regulation of t cell migration", "Regulation of t cell proliferation", "Regulation of t cell receptor signaling pathway", "Regulation of t circle formation", "Regulation of t helper 1 cell differentiation", "Regulation of t helper 1 type immune response", "Regulation of t helper 2 cell differentiation", "Regulation of t helper cell differentiation", "Regulation of tau protein kinase activity", "Regulation of telomerase activity", "Regulation of telomere capping", "Regulation of telomere maintenance", "Regulation of telomere maintenance via telomere lengthening", "Regulation of tetrapyrrole metabolic process", "Regulation of the force of heart contraction", "Regulation of thymocyte apoptotic process", "Regulation of tissue remodeling", "Regulation of tolerance induction", "Regulation of toll like receptor 3 signaling pathway", "Regulation of toll like receptor 4 signaling pathway", "Regulation of toll like receptor 7 signaling pathway", "Regulation of toll like receptor 9 signaling pathway", "Regulation of toll like receptor signaling pathway", "Regulation of tor signaling", "Regulation of torc2 signaling", "Regulation of trail activated apoptotic signaling pathway", "Regulation of trans synaptic signaling", "Regulation of transcription by glucose", "Regulation of transcription by rna polymerase i", "Regulation of transcription by rna polymerase iii", "Regulation of transcription elongation from rna polymerase ii promoter", "Regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Regulation of transcription from rna polymerase ii promoter in response to oxidative stress", "Regulation of transcription from rna polymerase ii promoter involved in heart development", "Regulation of transcription involved in g1 s transition of mitotic cell cycle", "Regulation of transcription of nucleolar large rrna by rna polymerase i", "Regulation of transcription regulatory region dna binding", "Regulation of transferase activity", "Regulation of transforming growth factor beta activation", "Regulation of transforming growth factor beta1 production", "Regulation of translation at synapse modulating synaptic transmission", "Regulation of translation in response to endoplasmic reticulum stress", "Regulation of translation in response to stress", "Regulation of translation initiation in response to endoplasmic reticulum stress", "Regulation of translational elongation", "Regulation of translational fidelity", "Regulation of translational initiation", "Regulation of translational initiation by eif2 alpha phosphorylation", "Regulation of translational initiation in response to stress", "Regulation of translational termination", "Regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Regulation of transmembrane transport", "Regulation of transmission of nerve impulse", "Regulation of transport", "Regulation of transporter activity", "Regulation of transposition", "Regulation of triglyceride biosynthetic process", "Regulation of triglyceride catabolic process", "Regulation of triglyceride metabolic process", "Regulation of tube size", "Regulation of tumor necrosis factor mediated signaling pathway", "Regulation of type b pancreatic cell development", "Regulation of type i interferon mediated signaling pathway", "Regulation of ubiquitin dependent protein catabolic process", "Regulation of ubiquitin protein ligase activity", "Regulation of ubiquitin protein transferase activity", "Regulation of ubiquitin specific protease activity", "Regulation of unsaturated fatty acid biosynthetic process", "Regulation of urine volume", "Regulation of vacuole organization", "Regulation of vascular associated smooth muscle cell differentiation", "Regulation of vascular associated smooth muscle contraction", "Regulation of vascular endothelial growth factor receptor signaling pathway", "Regulation of vascular permeability", "Regulation of vascular wound healing", "Regulation of vasculature development", "Regulation of vasculogenesis", "Regulation of vasoconstriction", "Regulation of ventricular cardiac muscle cell action potential", "Regulation of ventricular cardiac muscle cell membrane depolarization", "Regulation of very low density lipoprotein particle clearance", "Regulation of vesicle fusion", "Regulation of vesicle mediated transport", "Regulation of vesicle size", "Regulation of viral entry into host cell", "Regulation of viral genome replication", "Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Regulation of viral process", "Regulation of viral transcription", "Regulation of vitamin d receptor signaling pathway", "Regulation of vitamin metabolic process", "Regulation of voltage gated calcium channel activity", "Regulation of water loss via skin", "Regulation of wnt signaling pathway", "Regulation of wnt signaling pathway involved in heart development", "Regulation of wnt signaling pathway planar cell polarity pathway", "Regulation of wound healing", "Regulation of wound healing spreading of epidermal cells", "Regulation of xenophagy", "Regulatory t cell differentiation", "Relaxation of cardiac muscle", "Relaxation of muscle", "Release of cytochrome c from mitochondria", "Release of sequestered calcium ion into cytosol by endoplasmic reticulum", "Renal absorption", "Renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure", "Renal filtration", "Renal sodium excretion", "Renal sodium ion absorption", "Renal sodium ion transport", "Renal system process", "Renal system process involved in regulation of systemic arterial blood pressure", "Renal system vasculature development", "Renal system vasculature morphogenesis", "Renal tubular secretion", "Renal tubule development", "Renal vesicle development", "Renal vesicle formation", "Renal water homeostasis", "Replacement ossification", "Replication born double strand break repair via sister chromatid exchange", "Replication fork processing", "Replication fork protection", "Replicative senescence", "Reproduction", "Reproductive behavior", "Reproductive system development", "Rescue of stalled ribosome", "Resolution of meiotic recombination intermediates", "Respiratory burst", "Respiratory burst involved in defense response", "Respiratory burst involved in inflammatory response", "Respiratory chain complex iii assembly", "Respiratory chain complex iv assembly", "Respiratory electron transport chain", "Respiratory gaseous exchange by respiratory system", "Respiratory system development", "Respiratory system process", "Response to abiotic stimulus", "Response to acetylcholine", "Response to acid chemical", "Response to acidic ph", "Response to actinomycin d", "Response to activity", "Response to alcohol", "Response to aldosterone", "Response to alkaloid", "Response to amine", "Response to amino acid starvation", "Response to ammonium ion", "Response to amphetamine", "Response to amyloid beta", "Response to angiotensin", "Response to antibiotic", "Response to arsenic containing substance", "Response to arsenite ion", "Response to atp", "Response to auditory stimulus", "Response to axon injury", "Response to bacterium", "Response to bmp", "Response to cadmium ion", "Response to caffeine", "Response to calcium ion", "Response to camp", "Response to carbohydrate", "Response to catecholamine", "Response to cell cycle checkpoint signaling", "Response to cgmp", "Response to chemokine", "Response to cholesterol", "Response to cisplatin", "Response to cobalt ion", "Response to cocaine", "Response to cold", "Response to copper ion", "Response to corticosteroid", "Response to corticosterone", "Response to cortisol", "Response to cytokine", "Response to dexamethasone", "Response to dietary excess", "Response to dopamine", "Response to dsrna", "Response to electrical stimulus", "Response to endogenous stimulus", "Response to endoplasmic reticulum stress", "Response to epidermal growth factor", "Response to epinephrine", "Response to estradiol", "Response to estrogen", "Response to ethanol", "Response to ether", "Response to extracellular stimulus", "Response to fatty acid", "Response to fibroblast growth factor", "Response to fluid shear stress", "Response to folic acid", "Response to follicle stimulating hormone", "Response to food", "Response to forskolin", "Response to fungus", "Response to gamma radiation", "Response to glucagon", "Response to glycoprotein", "Response to glycoside", "Response to gonadotropin", "Response to granulocyte macrophage colony stimulating factor", "Response to growth factor", "Response to growth hormone", "Response to heat", "Response to heparin", "Response to hepatocyte growth factor", "Response to herbicide", "Response to histamine", "Response to hormone", "Response to human chorionic gonadotropin", "Response to hydrogen peroxide", "Response to hydroperoxide", "Response to hydrostatic pressure", "Response to hydroxyurea", "Response to hyperoxia", "Response to immobilization stress", "Response to inactivity", "Response to increased oxygen levels", "Response to indole 3 methanol", "Response to inorganic substance", "Response to insecticide", "Response to insulin", "Response to interferon alpha", "Response to interferon beta", "Response to interferon gamma", "Response to interleukin 1", "Response to interleukin 12", "Response to interleukin 3", "Response to interleukin 4", "Response to interleukin 6", "Response to interleukin 7", "Response to ionizing radiation", "Response to iron ii ion", "Response to iron ion", "Response to ischemia", "Response to isoquinoline alkaloid", "Response to ketone", "Response to l ascorbic acid", "Response to l glutamate", "Response to l phenylalanine derivative", "Response to lead ion", "Response to lectin", "Response to leptin", "Response to leucine", "Response to leukemia inhibitory factor", "Response to light intensity", "Response to light stimulus", "Response to lipid", "Response to lipoteichoic acid", "Response to lithium ion", "Response to magnesium ion", "Response to manganese ion", "Response to mechanical stimulus", "Response to mercury ion", "Response to metal ion", "Response to methylmercury", "Response to mineralocorticoid", "Response to misfolded protein", "Response to mitochondrial depolarisation", "Response to molecule of bacterial origin", "Response to monosaccharide", "Response to muramyl dipeptide", "Response to muscle activity", "Response to muscle inactivity", "Response to muscle stretch", "Response to nerve growth factor", "Response to nicotine", "Response to nitric oxide", "Response to nitrogen compound", "Response to nitrosative stress", "Response to nutrient", "Response to oleic acid", "Response to organic cyclic compound", "Response to osmotic stress", "Response to oxidative stress", "Response to oxygen containing compound", "Response to oxygen glucose deprivation", "Response to oxygen levels", "Response to oxygen radical", "Response to pain", "Response to parathyroid hormone", "Response to peptide", "Response to peptide hormone", "Response to peptidoglycan", "Response to ph", "Response to phorbol 13 acetate 12 myristate", "Response to platelet derived growth factor", "Response to potassium ion", "Response to progesterone", "Response to prostaglandin", "Response to prostaglandin e", "Response to purine containing compound", "Response to radiation", "Response to reactive oxygen species", "Response to redox state", "Response to retinoic acid", "Response to salt", "Response to salt stress", "Response to selenium ion", "Response to sodium arsenite", "Response to sorbitol", "Response to starvation", "Response to steroid hormone", "Response to sterol", "Response to sterol depletion", "Response to stimulus involved in regulation of muscle adaptation", "Response to temperature stimulus", "Response to testosterone", "Response to thyroglobulin triiodothyronine", "Response to thyroid hormone", "Response to thyroxine", "Response to topologically incorrect protein", "Response to toxic substance", "Response to transforming growth factor beta", "Response to tumor cell", "Response to tumor necrosis factor", "Response to type i interferon", "Response to uv", "Response to uv a", "Response to uv b", "Response to uv c", "Response to virus", "Response to vitamin", "Response to vitamin a", "Response to vitamin d", "Response to vitamin k", "Response to water", "Response to wounding", "Response to x ray", "Response to xenobiotic stimulus", "Response to yeast", "Response to zinc ion", "Reticulophagy", "Retina development in camera type eye", "Retina homeostasis", "Retina layer formation", "Retina morphogenesis in camera type eye", "Retina vasculature development in camera type eye", "Retina vasculature morphogenesis in camera type eye", "Retinal cell apoptotic process", "Retinal cone cell differentiation", "Retinal ganglion cell axon guidance", "Retinal metabolic process", "Retinal pigment epithelium development", "Retinal rod cell development", "Retinal rod cell differentiation", "Retinoic acid metabolic process", "Retinoic acid receptor signaling pathway", "Retinol metabolic process", "Retrograde axonal transport", "Retrograde trans synaptic signaling", "Retrograde trans synaptic signaling by lipid", "Retrograde transport endosome to golgi", "Retrograde transport vesicle recycling within golgi", "Retrograde vesicle mediated transport golgi to endoplasmic reticulum", "Reverse cholesterol transport", "Reversible differentiation", "Rho protein signal transduction", "Rhodopsin mediated signaling pathway", "Rhythmic behavior", "Rhythmic process", "Riboflavin metabolic process", "Ribonucleoprotein complex biogenesis", "Ribonucleoprotein complex disassembly", "Ribonucleoprotein complex localization", "Ribonucleoprotein complex subunit organization", "Ribonucleoside catabolic process", "Ribonucleoside diphosphate biosynthetic process", "Ribonucleoside diphosphate catabolic process", "Ribonucleoside diphosphate metabolic process", "Ribonucleoside metabolic process", "Ribonucleoside monophosphate biosynthetic process", "Ribonucleoside monophosphate catabolic process", "Ribonucleoside monophosphate metabolic process", "Ribonucleoside triphosphate biosynthetic process", "Ribonucleoside triphosphate metabolic process", "Ribonucleotide catabolic process", "Ribose phosphate biosynthetic process", "Ribose phosphate metabolic process", "Ribosomal large subunit assembly", "Ribosomal large subunit biogenesis", "Ribosomal large subunit export from nucleus", "Ribosomal small subunit assembly", "Ribosomal small subunit biogenesis", "Ribosomal small subunit export from nucleus", "Ribosomal subunit export from nucleus", "Ribosome assembly", "Ribosome associated ubiquitin dependent protein catabolic process", "Ribosome biogenesis", "Ribosome disassembly", "Rig i signaling pathway", "Righting reflex", "Rna 3 end processing", "Rna 5 end processing", "Rna capping", "Rna catabolic process", "Rna decapping", "Rna dependent dna biosynthetic process", "Rna destabilization", "Rna export from nucleus", "Rna guanine n7 methylation", "Rna import into mitochondrion", "Rna interference", "Rna localization", "Rna mediated gene silencing by inhibition of translation", "Rna methylation", "Rna modification", "Rna phosphodiester bond hydrolysis", "Rna phosphodiester bond hydrolysis endonucleolytic", "Rna phosphodiester bond hydrolysis exonucleolytic", "Rna polyadenylation", "Rna polymerase i preinitiation complex assembly", "Rna polymerase ii preinitiation complex assembly", "Rna processing", "Rna secondary structure unwinding", "Rna splicing", "Rna splicing via endonucleolytic cleavage and ligation", "Rna splicing via transesterification reactions", "Rna stabilization", "Rna surveillance", "Roof of mouth development", "Rostrocaudal neural tube patterning", "Roundabout signaling pathway", "Rrna 3 end processing", "Rrna 5 end processing", "Rrna base methylation", "Rrna catabolic process", "Rrna metabolic process", "Rrna methylation", "Rrna modification", "Rrna pseudouridine synthesis", "Rrna transcription", "Rrna transport", "Ruffle assembly", "Ruffle organization", "S adenosylmethionine cycle", "S adenosylmethionine metabolic process", "Salivary gland development", "Sarcomere organization", "Sarcoplasmic reticulum calcium ion transport", "Satellite cell activation involved in skeletal muscle regeneration", "Scarna localization to cajal body", "Scf dependent proteasomal ubiquitin dependent protein catabolic process", "Schwann cell development", "Schwann cell differentiation", "Schwann cell proliferation", "Sebaceous gland development", "Second messenger mediated signaling", "Secondary alcohol metabolic process", "Secondary heart field specification", "Secondary metabolic process", "Secondary metabolite biosynthetic process", "Secondary palate development", "Secretion", "Secretion by tissue", "Secretion of lysosomal enzymes", "Secretory granule localization", "Secretory granule organization", "Segment specification", "Segmentation", "Selective autophagy", "Self proteolysis", "Semaphorin plexin signaling pathway", "Semaphorin plexin signaling pathway involved in neuron projection guidance", "Semi lunar valve development", "Sensory organ development", "Sensory organ morphogenesis", "Sensory perception", "Sensory perception of light stimulus", "Sensory perception of mechanical stimulus", "Sensory perception of pain", "Sensory system development", "Septum primum development", "Sequestering of actin monomers", "Sequestering of calcium ion", "Sequestering of iron ion", "Sequestering of metal ion", "Sequestering of triglyceride", "Sequestering of zinc ion", "Serine family amino acid biosynthetic process", "Serine family amino acid catabolic process", "Serine family amino acid metabolic process", "Serine phosphorylation of stat protein", "Serine transport", "Serotonin metabolic process", "Sertoli cell development", "Sertoli cell differentiation", "Sex determination", "Sex differentiation", "Short chain fatty acid catabolic process", "Short chain fatty acid metabolic process", "Short term memory", "Sialylation", "Signal peptide processing", "Signal release", "Signal transduction by p53 class mediator", "Signal transduction in absence of ligand", "Signal transduction in response to dna damage", "Signal transduction involved in regulation of gene expression", "Signaling receptor ligand precursor processing", "Single fertilization", "Single strand break repair", "Single stranded viral rna replication via double stranded dna intermediate", "Sister chromatid cohesion", "Sister chromatid segregation", "Skeletal muscle acetylcholine gated channel clustering", "Skeletal muscle adaptation", "Skeletal muscle cell differentiation", "Skeletal muscle cell proliferation", "Skeletal muscle contraction", "Skeletal muscle fiber differentiation", "Skeletal muscle organ development", "Skeletal muscle satellite cell activation", "Skeletal muscle tissue regeneration", "Skeletal myofibril assembly", "Skeletal system development", "Skeletal system morphogenesis", "Skin development", "Skin epidermis development", "Skin morphogenesis", "Sleep", "Smad protein complex assembly", "Smad protein signal transduction", "Small gtpase mediated signal transduction", "Small molecule biosynthetic process", "Small molecule catabolic process", "Small molecule metabolic process", "Small nucleolar ribonucleoprotein complex assembly", "Small rna loading onto risc", "Smooth muscle adaptation", "Smooth muscle cell apoptotic process", "Smooth muscle cell chemotaxis", "Smooth muscle cell differentiation", "Smooth muscle cell migration", "Smooth muscle cell proliferation", "Smooth muscle contraction", "Smooth muscle tissue development", "Smoothened signaling pathway", "Smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Snare complex assembly", "Sno s rna metabolic process", "Sno s rna processing", "Snorna localization", "Snrna metabolic process", "Snrna modification", "Snrna processing", "Snrna transcription", "Snrna transcription by rna polymerase ii", "Snrna transport", "Sodium independent organic anion transport", "Sodium ion export across plasma membrane", "Sodium ion homeostasis", "Sodium ion import across plasma membrane", "Sodium ion transmembrane transport", "Sodium ion transport", "Somatic diversification of immune receptors", "Somatic diversification of immune receptors via somatic mutation", "Somatic diversification of immunoglobulins", "Somatic diversification of immunoglobulins involved in immune response", "Somatic diversification of t cell receptor genes", "Somatic stem cell population maintenance", "Somite development", "Somite rostral caudal axis specification", "Somitogenesis", "Specification of animal organ identity", "Specification of symmetry", "Sperm capacitation", "Sperm dna condensation", "Sperm egg recognition", "Sperm motility", "Spermatid differentiation", "Spermatid nucleus differentiation", "Spermidine metabolic process", "Spermine metabolic process", "Sphingoid metabolic process", "Sphingolipid biosynthetic process", "Sphingolipid mediated signaling pathway", "Sphingolipid metabolic process", "Sphingolipid translocation", "Sphingomyelin biosynthetic process", "Sphingomyelin catabolic process", "Sphingomyelin metabolic process", "Sphingosine biosynthetic process", "Spinal cord development", "Spinal cord motor neuron differentiation", "Spindle assembly", "Spindle assembly involved in female meiosis", "Spindle elongation", "Spindle localization", "Spindle midzone assembly", "Spindle organization", "Spleen development", "Spliceosomal complex assembly", "Spliceosomal conformational changes to generate catalytic conformation", "Spliceosomal snrnp assembly", "Spliceosomal tri snrnp complex assembly", "Spontaneous synaptic transmission", "Sprouting angiogenesis", "Srp dependent cotranslational protein targeting to membrane", "Srp dependent cotranslational protein targeting to membrane signal sequence recognition", "Srp dependent cotranslational protein targeting to membrane translocation", "Startle response", "Stem cell differentiation", "Stem cell division", "Stem cell proliferation", "Steroid biosynthetic process", "Steroid catabolic process", "Steroid esterification", "Steroid hormone biosynthetic process", "Steroid hormone mediated signaling pathway", "Steroid hormone secretion", "Steroid metabolic process", "Sterol biosynthetic process", "Sterol homeostasis", "Sterol import", "Sterol metabolic process", "Sterol transport", "Stomach development", "Stress activated protein kinase signaling cascade", "Stress fiber assembly", "Stress granule assembly", "Stress granule disassembly", "Stress induced premature senescence", "Stress response to metal ion", "Striated muscle adaptation", "Striated muscle cell apoptotic process", "Striated muscle cell development", "Striated muscle cell differentiation", "Striated muscle cell proliferation", "Striated muscle contraction", "Striatum development", "Subpallium development", "Substantia nigra development", "Substrate adhesion dependent cell spreading", "Substrate dependent cell migration", "Substrate dependent cell migration cell extension", "Substrate independent telencephalic tangential migration", "Subtelomeric heterochromatin assembly", "Succinate metabolic process", "Succinate transmembrane transport", "Succinyl coa metabolic process", "Suckling behavior", "Sugar mediated signaling pathway", "Sulfate transport", "Sulfur amino acid biosynthetic process", "Sulfur amino acid catabolic process", "Sulfur amino acid metabolic process", "Sulfur compound biosynthetic process", "Sulfur compound catabolic process", "Sulfur compound metabolic process", "Sulfur compound transport", "Superoxide anion generation", "Superoxide metabolic process", "Suppression of viral release by host", "Supramolecular fiber organization", "Sympathetic ganglion development", "Sympathetic nervous system development", "Synapse assembly", "Synapse maturation", "Synapse organization", "Synapse pruning", "Synaptic membrane adhesion", "Synaptic signaling", "Synaptic transmission dopaminergic", "Synaptic transmission gabaergic", "Synaptic transmission glutamatergic", "Synaptic vesicle budding", "Synaptic vesicle clustering", "Synaptic vesicle cytoskeletal transport", "Synaptic vesicle docking", "Synaptic vesicle endosomal processing", "Synaptic vesicle exocytosis", "Synaptic vesicle localization", "Synaptic vesicle maturation", "Synaptic vesicle membrane organization", "Synaptic vesicle priming", "Synaptic vesicle recycling", "Synaptic vesicle recycling via endosome", "Synaptic vesicle transport", "Synaptic vesicle uncoating", "Synaptonemal complex organization", "Syncytium formation", "T cell activation", "T cell activation involved in immune response", "T cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell", "T cell apoptotic process", "T cell chemotaxis", "T cell cytokine production", "T cell differentiation", "T cell differentiation in thymus", "T cell differentiation involved in immune response", "T cell extravasation", "T cell homeostasis", "T cell lineage commitment", "T cell mediated cytotoxicity", "T cell mediated immune response to tumor cell", "T cell mediated immunity", "T cell migration", "T cell proliferation", "T cell proliferation involved in immune response", "T cell receptor signaling pathway", "T cell selection", "T cell tolerance induction", "T helper 1 cell differentiation", "T helper 1 type immune response", "T helper 17 cell differentiation", "T helper 17 cell lineage commitment", "T helper 17 type immune response", "T helper 2 cell differentiation", "T helper cell lineage commitment", "T tubule organization", "Tail anchored membrane protein insertion into er membrane", "Tangential migration from the subventricular zone to the olfactory bulb", "Taurine transport", "Taxis", "Telencephalon development", "Telencephalon glial cell migration", "Telencephalon regionalization", "Telomerase holoenzyme complex assembly", "Telomerase rna localization", "Telomere capping", "Telomere maintenance", "Telomere maintenance in response to dna damage", "Telomere maintenance via recombination", "Telomere maintenance via semi conservative replication", "Telomere maintenance via telomere lengthening", "Telomere organization", "Temperature homeostasis", "Terminal button organization", "Termination of rna polymerase ii transcription", "Terpenoid biosynthetic process", "Terpenoid metabolic process", "Tertiary alcohol metabolic process", "Tetrahydrobiopterin metabolic process", "Tetrahydrofolate biosynthetic process", "Tetrahydrofolate interconversion", "Tetrahydrofolate metabolic process", "Tetrapyrrole biosynthetic process", "Tetrapyrrole catabolic process", "Tetrapyrrole metabolic process", "Thalamus development", "Thiamine containing compound metabolic process", "Thiamine transport", "Thioester biosynthetic process", "Thioester metabolic process", "Thorax and anterior abdomen determination", "Threonine catabolic process", "Threonine metabolic process", "Thrombin activated receptor signaling pathway", "Thrombopoietin mediated signaling pathway", "Thymocyte apoptotic process", "Thymus development", "Thyroid gland development", "Thyroid hormone generation", "Thyroid hormone mediated signaling pathway", "Thyroid hormone metabolic process", "Tight junction organization", "Tissue development", "Tissue migration", "Tissue morphogenesis", "Tissue regeneration", "Tissue remodeling", "Tolerance induction", "Toll like receptor 3 signaling pathway", "Toll like receptor 4 signaling pathway", "Toll like receptor 7 signaling pathway", "Toll like receptor 8 signaling pathway", "Toll like receptor 9 signaling pathway", "Toll like receptor signaling pathway", "Tongue development", "Tongue morphogenesis", "Tooth mineralization", "Tor signaling", "Torc1 signaling", "Torc2 signaling", "Toxin metabolic process", "Toxin transport", "Trabecula morphogenesis", "Trachea development", "Trachea formation", "Trachea morphogenesis", "Trail activated apoptotic signaling pathway", "Trans synaptic signaling by lipid", "Trans synaptic signaling by trans synaptic complex", "Transcription by rna polymerase i", "Transcription by rna polymerase iii", "Transcription coupled nucleotide excision repair", "Transcription dependent tethering of rna polymerase ii gene dna at nuclear periphery", "Transcription elongation from rna polymerase i promoter", "Transcription elongation from rna polymerase ii promoter", "Transcription initiation from rna polymerase i promoter", "Transcription initiation from rna polymerase ii promoter", "Transcription initiation from rna polymerase iii promoter", "Transcription preinitiation complex assembly", "Transcytosis", "Transdifferentiation", "Transepithelial chloride transport", "Transepithelial transport", "Transferrin transport", "Transforming growth factor beta activation", "Transforming growth factor beta production", "Transforming growth factor beta receptor signaling pathway", "Transforming growth factor beta1 production", "Transition between fast and slow fiber", "Transition metal ion homeostasis", "Transition metal ion transport", "Translational elongation", "Translational initiation", "Translational readthrough", "Translational termination", "Translesion synthesis", "Translocation of molecules into host", "Transmembrane receptor protein serine threonine kinase signaling pathway", "Transmembrane receptor protein tyrosine kinase signaling pathway", "Transmembrane receptor protein tyrosine phosphatase signaling pathway", "Transmembrane transport", "Transmission of nerve impulse", "Transport along microtubule", "Transport of virus", "Transposition", "Transposition rna mediated", "Tricarboxylic acid cycle", "Tricarboxylic acid metabolic process", "Trigeminal ganglion development", "Trigeminal nerve development", "Trigeminal nerve morphogenesis", "Triglyceride biosynthetic process", "Triglyceride catabolic process", "Triglyceride metabolic process", "Tripartite regional subdivision", "Tripeptide transport", "Trivalent inorganic anion homeostasis", "Trna 3 end processing", "Trna 5 end processing", "Trna 5 leader removal", "Trna aminoacylation for mitochondrial protein translation", "Trna catabolic process", "Trna metabolic process", "Trna methylation", "Trna modification", "Trna processing", "Trna pseudouridine synthesis", "Trna thio modification", "Trna threonylcarbamoyladenosine metabolic process", "Trna transcription", "Trna transport", "Trna wobble base modification", "Trna wobble uridine modification", "Trophectodermal cell differentiation", "Trophoblast cell migration", "Trophoblast giant cell differentiation", "Tryptophan transport", "Tube development", "Tube formation", "Tube morphogenesis", "Tubulin complex assembly", "Tubulin deacetylation", "Tumor necrosis factor mediated signaling pathway", "Tumor necrosis factor superfamily cytokine production", "Type 2 immune response", "Type b pancreatic cell apoptotic process", "Type b pancreatic cell development", "Type b pancreatic cell proliferation", "Type i interferon production", "Type i pneumocyte differentiation", "Tyrosine catabolic process", "Tyrosine metabolic process", "Tyrosine phosphorylation of stat protein", "U4 snrna 3 end processing", "Ubiquinone metabolic process", "Ubiquitin dependent endocytosis", "Ubiquitin dependent erad pathway", "Ubiquitin dependent glycoprotein erad pathway", "Ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin dependent smad protein catabolic process", "Ubiquitin independent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin recycling", "Udp glucose metabolic process", "Udp n acetylglucosamine biosynthetic process", "Udp n acetylglucosamine metabolic process", "Ump biosynthetic process", "Unsaturated fatty acid biosynthetic process", "Unsaturated fatty acid metabolic process", "Urate metabolic process", "Urea cycle", "Urea metabolic process", "Ureter development", "Urinary bladder smooth muscle contraction", "Urinary tract smooth muscle contraction", "Urogenital system development", "Uronic acid metabolic process", "Uterus development", "Uterus morphogenesis", "Utp biosynthetic process", "Utp metabolic process", "Uv damage excision repair", "Uv protection", "V d j recombination", "Vacuolar acidification", "Vacuolar localization", "Vacuolar proton transporting v type atpase complex assembly", "Vacuolar transport", "Vacuole organization", "Valine metabolic process", "Vascular associated smooth muscle cell apoptotic process", "Vascular associated smooth muscle cell differentiation", "Vascular associated smooth muscle cell migration", "Vascular associated smooth muscle cell proliferation", "Vascular associated smooth muscle contraction", "Vascular endothelial cell proliferation", "Vascular endothelial growth factor production", "Vascular endothelial growth factor receptor 2 signaling pathway", "Vascular endothelial growth factor receptor signaling pathway", "Vascular endothelial growth factor signaling pathway", "Vascular process in circulatory system", "Vascular transport", "Vascular wound healing", "Vasculature development", "Vasculogenesis", "Vasoconstriction", "Vasodilation", "Ventral spinal cord development", "Ventricular cardiac muscle cell action potential", "Ventricular cardiac muscle cell development", "Ventricular cardiac muscle cell differentiation", "Ventricular cardiac muscle cell membrane repolarization", "Ventricular cardiac muscle tissue development", "Ventricular cardiac muscle tissue morphogenesis", "Ventricular compact myocardium morphogenesis", "Ventricular septum development", "Ventricular septum morphogenesis", "Ventricular system development", "Ventricular trabecula myocardium morphogenesis", "Very long chain fatty acid catabolic process", "Very long chain fatty acid metabolic process", "Very low density lipoprotein particle assembly", "Very low density lipoprotein particle clearance", "Vesicle budding from membrane", "Vesicle cargo loading", "Vesicle cytoskeletal trafficking", "Vesicle docking", "Vesicle docking involved in exocytosis", "Vesicle fusion to plasma membrane", "Vesicle fusion with golgi apparatus", "Vesicle localization", "Vesicle mediated cholesterol transport", "Vesicle mediated transport", "Vesicle mediated transport between endosomal compartments", "Vesicle mediated transport in synapse", "Vesicle mediated transport to the plasma membrane", "Vesicle organization", "Vesicle targeting", "Vesicle targeting rough er to cis golgi", "Vesicle targeting to from or within golgi", "Vesicle tethering", "Vesicle tethering to golgi", "Vesicle transport along microtubule", "Vesicle uncoating", "Vestibulocochlear nerve development", "Vestibulocochlear nerve morphogenesis", "Viral budding", "Viral gene expression", "Viral genome replication", "Viral life cycle", "Viral process", "Viral protein processing", "Viral release from host cell", "Viral rna genome replication", "Viral transcription", "Viral translation", "Viral translational termination reinitiation", "Virion assembly", "Virion attachment to host cell", "Visual behavior", "Vitamin a metabolic process", "Vitamin b6 metabolic process", "Vitamin biosynthetic process", "Vitamin catabolic process", "Vitamin d metabolic process", "Vitamin d receptor signaling pathway", "Vitamin k metabolic process", "Vitamin metabolic process", "Vitamin transmembrane transport", "Vitamin transport", "Vocalization behavior", "Voluntary musculoskeletal movement", "Walking behavior", "Water homeostasis", "Water soluble vitamin biosynthetic process", "Water soluble vitamin metabolic process", "Water transport", "White fat cell differentiation", "Wnt protein secretion", "Wnt signaling pathway involved in heart development", "Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "Wound healing", "Wound healing involved in inflammatory response", "Wound healing spreading of epidermal cells", "Xenobiotic catabolic process", "Xenobiotic export", "Xenobiotic metabolic process", "Xenobiotic transmembrane transport", "Xenobiotic transport", "Xenobiotic transport across blood brain barrier", "Xenophagy", "Xmp metabolic process", "Zinc ion homeostasis", "Zinc ion import across plasma membrane", "Zinc ion transport", "Zygotic determination of anterior posterior axis embryo", "Zymogen activation", "Zymogen inhibition"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGFG1", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "AKT2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALG9", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD13A", "ANLN", "ANO10", "ANO6", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APC", "APEH", "APEX1", "API5", "APOO", "APOOL", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARG2", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID4B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6", "ARL6IP1", "ARL6IP5", "ARL8B", "ARMC1", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC1", "ASCC2", "ASCC3", "ASF1A", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATG13", "ATG3", "ATG4B", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATP7B", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BABAM2", "BAG2", "BAG5", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS2", "BCCIP", "BCKDK", "BCL10", "BCL2L13", "BCLAF1", "BCS1L", "BEND3", "BICD2", "BIRC6", "BLMH", "BLOC1S1", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BRAP", "BRAT1", "BRCA1", "BRD1", "BRD2", "BRD3", "BRD4", "BRD7", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf43", "C12orf73", "C17orf75", "C19orf70", "C1QBP", "C2CD5", "CAB39", "CACYBP", "CAD", "CALCOCO1", "CALD1", "CALR", "CAMK2D", "CAMK2G", "CAMSAP3", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CC2D1A", "CCAR1", "CCAR2", "CCDC124", "CCDC22", "CCDC47", "CCDC6", "CCDC8", "CCDC93", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CCZ1B", "CD276", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK16", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK5RAP2", "CDK5RAP3", "CDK7", "CDK9", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPV", "CEP290", "CEP44", "CETN2", "CFAP20", "CFL1", "CFL2", "CGGBP1", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHEK2", "CHERP", "CHID1", "CHKA", "CHMP1A", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHP1", "CHRAC1", "CHST14", "CIAPIN1", "CIRBP", "CISD1", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT3", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COASY", "COG3", "COG4", "COG7", "COG8", "COIL", "COLEC12", "COLGALT1", "COMMD1", "COMMD7", "COMT", "COMTD1", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "COQ8A", "CORO1C", "COTL1", "COX11", "COX14", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7A2L", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK1E", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CTTNBP2NL", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUL7", "CUTA", "CWF19L1", "CXADR", "CXorf56", "CXorf57", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCP1B", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTPP1", "DCUN1D5", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DERL1", "DFFA", "DGCR8", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DR1", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUS2", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYM", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHHADH", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC3", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EXD2", "EXO1", "EXOC2", "EXOC4", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAM129B", "FAM162A", "FAM208A", "FAM213A", "FAM3C", "FAM49B", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXO22", "FBXO7", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FKRP", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FNBP1", "FNDC3A", "FNTA", "FNTB", "FOXK1", "FOXK2", "FOXRED1", "FRG1", "FSCN1", "FTL", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLC", "GCN1", "GDAP1", "GDE1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GGH", "GGPS1", "GHITM", "GID4", "GIGYF2", "GINS1", "GINS2", "GINS3", "GINS4", "GIPC1", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLTP", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAO1", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLPH3", "GOLT1B", "GORASP2", "GOSR1", "GOSR2", "GOT1", "GOT2", "GPAT4", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR89B", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2H4", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD2", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAT1", "HAUS1", "HAUS2", "HAUS4", "HAUS5", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCR", "HMGCS1", "HMGN1", "HMGXB4", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IFT88", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKG", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INCENP", "INF2", "INPP4A", "INTS1", "INTS10", "INTS11", "INTS12", "INTS14", "INTS3", "INTS8", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "IRF2BPL", "IRS4", "ISCU", "IST1", "ISYNA1", "ITGAV", "ITGB1", "ITPA", "ITPRIP", "IVD", "IWS1", "JAGN1", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIAA1468", "KIF11", "KIF14", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LCMT2", "LDAH", "LDB1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC59", "LRRC8C", "LRWD1", "LSM14B", "LSM2", "LSM4", "LSM6", "LSS", "LTA4H", "LTV1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LYPLA2", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MAN1A1", "MAN1A2", "MAN2A1", "MANF", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4", "MAP7D1", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARK2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED16", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METAP2", "METTL1", "METTL13", "METTL3", "MFAP1", "MFF", "MFN2", "MFSD10", "MFSD5", "MFSD8", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIEF1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMGT1", "MMS19", "MOGS", "MORC2", "MORF4L1", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL20", "MRPL22", "MRPL27", "MRPL3", "MRPL37", "MRPL41", "MRPL43", "MRPL44", "MRPL47", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS17", "MRPS2", "MRPS21", "MRPS27", "MRPS28", "MRPS30", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MUT", "MVD", "MYBBP1A", "MYCBP", "MYCBP2", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAF1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCDN", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCOR1", "NCSTN", "ND5", "NDC1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB11", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS5", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFB", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NF1", "NFATC2IP", "NFRKB", "NFS1", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP2", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP10", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPHP3", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRP1", "NSA2", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDCD3", "NUDT1", "NUDT16L1", "NUDT19", "NUDT21", "NUDT5", "NUDT9", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OMA1", "OPA1", "OPA3", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP2", "PAK1IP1", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARL", "PARN", "PARP1", "PARP2", "PBK", "PBRM1", "PBXIP1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDS5A", "PDS5B", "PDSS2", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PHAX", "PHB", "PHB2", "PHC2", "PHF10", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHPT1", "PI4K2A", "PI4KA", "PICALM", "PIGG", "PIGK", "PIGS", "PIGT", "PIH1D1", "PIK3C2A", "PIK3R2", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNN", "PNP", "PNPLA6", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLE4", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2D", "POLR2G", "POLR2L", "POLR3A", "POLR3C", "POLR3E", "POLRMT", "PON2", "POP1", "POR", "PPA2", "PPAN", "PPAT", "PPFIA1", "PPHLN1", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R14B", "PPP1R9B", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRELID3B", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSMG1", "PSMG3", "PSPC1", "PSPH", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RABGEF1", "RABGGTA", "RABL3", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALGAPB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANGAP1", "RAP1GDS1", "RAP2B", "RAPGEF2", "RARS", "RASA1", "RAVER1", "RBBP5", "RBBP6", "RBFA", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM39", "RBM4", "RBM42", "RBM47", "RBM5", "RBM6", "RBM7", "RBM8A", "RBMX", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REPS1", "RER1", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT2", "RIDA", "RIF1", "RINT1", "RIOK2", "RIPK1", "RMDN1", "RMDN3", "RMND1", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF219", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPA3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS27", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCA", "RTCB", "RTF1", "RTFDC1", "RTN1", "RTN2", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SC5D", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCAP", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SCRN3", "SCYL2", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHCBP1", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIN3A", "SIN3B", "SIRT1", "SIRT2", "SKA3", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC2A8", "SLC30A5", "SLC30A9", "SLC35A4", "SLC35B2", "SLC35F2", "SLC38A1", "SLC39A14", "SLC3A2", "SLC44A1", "SLC4A7", "SLC7A1", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMG5", "SMG8", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNIP1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX2", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPART", "SPATA5", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPDL1", "SPECC1L", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRFBP1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR3", "SSRP1", "ST3GAL4", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3NL", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK26", "STK38", "STK4", "STMN1", "STOML2", "STRAP", "STRBP", "STRIP1", "STRN", "STT3A", "STT3B", "STUB1", "STX10", "STX12", "STX18", "STX4", "STX5", "STX6", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE1", "SYNE2", "SYNGR2", "SYNJ2BP", "TAB1", "TACC3", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TARDBP", "TARS", "TARS2", "TARSL2", "TAX1BP1", "TBC1D10A", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDP2", "TECR", "TEFM", "TELO2", "TERF2IP", "TES", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THTPA", "THUMPD1", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM13", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIPRL", "TJP1", "TJP2", "TK1", "TKFC", "TKT", "TLCD1", "TLN1", "TLN2", "TM9SF2", "TM9SF3", "TM9SF4", "TMBIM6", "TMCO1", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM126B", "TMEM14C", "TMEM201", "TMEM214", "TMEM230", "TMEM33", "TMEM43", "TMEM65", "TMEM70", "TMEM87A", "TMEM97", "TMF1", "TMLHE", "TMOD3", "TMTC3", "TMX1", "TMX2", "TNKS1BP1", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1A", "TOR1AIP1", "TOR1AIP2", "TOR1B", "TP53", "TP53BP1", "TPBG", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC2L", "TRAPPC3", "TRAPPC5", "TRAPPC8", "TRIM13", "TRIM21", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIO", "TRIP10", "TRIP12", "TRIP13", "TRIP4", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSC2", "TSFM", "TSG101", "TSNAX", "TSPAN6", "TSPO", "TSPYL1", "TSR1", "TSR3", "TTC1", "TTC19", "TTC26", "TTC37", "TTC4", "TTC7B", "TTF2", "TTK", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBG1", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL4A", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAC1", "UBAP2L", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBL5", "UBLCP1", "UBP1", "UBQLN2", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UFSP2", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF3B", "UQCC1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP28", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VEZT", "VIM", "VIRMA", "VKORC1L1", "VMP1", "VPS13A", "VPS13C", "VPS16", "VPS18", "VPS25", "VPS26A", "VPS26B", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WARS2", "WBP11", "WBP2", "WDR1", "WDR12", "WDR18", "WDR26", "WDR3", "WDR36", "WDR4", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR7", "WDR70", "WDR73", "WDR74", "WDR75", "WDR76", "WDR77", "WDR82", "WFS1", "WIPI2", "WIZ", "WRAP53", "WTAP", "XAB2", "XPA", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YIF1A", "YIF1B", "YIPF4", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDF2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3H7B", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZDHHC6", "ZFYVE16", "ZMPSTE24", "ZMYM4", "ZNF207", "ZNF281", "ZNF318", "ZNF326", "ZNF512B", "ZNF598", "ZNF638", "ZPR1", "ZW10", "ZWILCH", "ZYX", "ZZZ3"], "leading_proteins": ["AAAS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABHD10", "ACAT2", "ACOX1", "ACP2", "ACP6", "ACSL1", "ADA", "ADD1", "ADPGK", "AFG3L2", "AGK", "AGPAT5", "AGPS", "AIFM1", "AKAP8L", "AKT2", "ALDH1B1", "ALDH3A2", "ALG1", "ALG12", "ALG9", "ALYREF", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANKLE2", "ANKRD13A", "ANO10", "ANO6", "ANXA1", "ANXA7", "AP1M1", "APC", "APOO", "APOOL", "ARFGAP1", "ARFIP1", "ARL6IP1", "ARL6IP5", "ARL8B", "ASAH1", "ASNA1", "ATAD3A", "ATAD3B", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5B", "ATP5F1", "ATP5H", "ATP5I", "ATP5L", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V1E1", "ATP7A", "ATP7B", "AUP1", "B3GALT6", "B4GAT1", "BAG6", "BAIAP2", "BASP1", "BCAP31", "BCL2L13", "BCS1L", "BICD2", "BLOC1S1", "BNIP1", "BOLA2*", "BSG", "BUB1B", "C12orf73", "C19orf70", "C1QBP", "CAB39", "CANX", "CASK", "CCDC22", "CCDC47", "CCNB1", "CD276", "CD47", "CDC23", "CDC27", "CDC73", "CDH2", "CDK1", "CDK2", "CDK4", "CDK9", "CDS2", "CHAC2", "CHCHD3", "CHD8", "CHKA", "CHMP1A", "CHMP2B", "CHMP3", "CHMP4B", "CHST14", "CIRBP", "CISD1", "CIZ1", "CLCN3", "CLN5", "CLPP", "CLPTM1", "CLUH", "CNNM3", "CNNM4", "COA3", "COG3", "COG7", "COMMD1", "COMT", "COPS4", "COPS8", "COX11", "COX14", "COX15", "COX2", "COX4I1", "COX5A", "COX7A2", "CPD", "CPNE3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRK", "CRTAP", "CSTF2", "CTNNB1", "CTNND1", "CTSA", "CTSC", "CUL5", "CUTA", "CXADR", "CYB5B", "CYB5R3", "CYP51A1", "DAG1", "DAGLB", "DCAKD", "DCTN1", "DCTN2", "DCTPP1", "DDRGK1", "DERL1", "DHCR24", "DHFR", "DHODH", "DHRS7", "DHRS7B", "DHX33", 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sha256:553beb1b3935a5e900b1bf7e0e70576b02faca7a8b3c3d184bf1abbf38eec04e +size 154339 diff --git a/msigdb_gocc/df_merge.tsv b/msigdb_gocc/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..918066e9fc885b13fb176745956f8267aa62ccbe --- /dev/null +++ b/msigdb_gocc/df_merge.tsv @@ -0,0 +1,87 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Inner mitochondrial membrane protein complex 43 76 4.806948710013415 1.5325128701615398e-06 27.97087378640777 75.4635922330097 1.520604987560478 0.2664687480104057 12.043574857699111 6.447783897817093 2.3558486082891616 0.3692317407906862 4.61251439878737e-19 2.4596417906673657e-06 2.39818821025266e-11 5.96420848862229e-17 9.707421461461188e-21 +Lysosomal lumen 24 33 4.684448218482023 2.807151204375913e-06 18.075242718446603 34.54368932038835 0.7848519845050315 0.1014568164283454 6.206531846566726 3.2976210873168883 3.038689298289951 0.2012423645269794 1.857865653483574e-18 1.5586950172181756e-05 1.488331722709146e-08 1.793717894839892e-14 2.378850464904629e-17 +Intrinsic component of mitochondrial membrane 35 46 4.649874327969697 3.321373491349533e-06 20.225728155339805 46.883495145631066 1.6360090381123027 0.2606204408334349 9.735582728924424 5.567853242112672 2.0682718238883013 0.3438986948818692 1.3952200028372185e-15 0.0531691841805127 0.0009512079801521 4.825978027817743e-09 1.4532470814101466e-17 +Intrinsic component of plasma membrane 54 78 4.604294394264732 4.138666670705504e-06 29.711165048543688 79.49271844660194 0.9914207279546418 0.2992612012372248 13.467745416506318 12.62980929789956 2.1277799030157807 0.3627370007757806 0.0095604913307896 0.6525907891399023 0.8330259814094686 0.033611002490351 0.0469435402672152 +Intrinsic component of organelle membrane 100 129 4.586728438817639 4.502457093158441e-06 52.51699029126213 129.34223300970874 2.0732064315361294 0.2796588394070637 24.692225942786415 15.820346456508432 2.8130846896968285 0.39829365000917 1.0364450133546039e-25 0.0525029693113603 5.641547629880334e-06 2.0684249047328882e-13 5.24827408253819e-32 +Vacuolar lumen 34 64 4.4337529975971846 9.2606718804511e-06 22.262135922330096 63.33980582524272 0.6562244405592584 0.1887666227175413 6.920437110961116 4.902057024259538 2.8947011026985514 0.298290072492813 3.7321484728764433e-16 0.0001945343448514 1.4653115333394006e-06 2.8532573062309848e-11 2.249232879763206e-16 +Intrinsic component of mitochondrial inner membrane 25 32 4.331653235675882 1.4799389415065534e-05 13.946601941747574 31.446601941747577 1.7062420859184484 0.2149692261988765 6.992163651608136 3.3601842163433866 1.8185871159494191 0.3070405082296492 1.8914379666197914e-13 0.0230307909848423 0.0001113664394611 2.099487500858404e-08 3.0701133345835803e-15 +Intrinsic component of endoplasmic reticulum membrane 30 53 4.134634304761335 3.5552029530316887e-05 21.439320388349515 53.03155339805825 1.5445183869163015 0.2945609219212759 9.936629672422429 6.151523176643304 2.1054078800196185 0.3580268322643601 5.391282149124201e-10 0.1184945425124205 0.0072395357132445 5.078931708252657e-05 7.482093225657308e-12 +Respirasome 19 46 3.950197865112416 7.808661294084196e-05 15.08495145631068 43.37378640776699 1.2524823540042158 0.2922262294299136 6.290312072426717 4.489587979561489 1.7783434517583476 0.3462844006183536 6.251231233635842e-11 0.0006619831437869 1.429145151632323e-06 1.4463018497939332e-10 4.036559845973957e-10 +Outer membrane 34 91 3.873827785828023 0.000107139136408 28.936893203883496 87.79611650485437 1.4859238244628277 0.3236686433663402 11.632349354832256 8.24751710010496 1.9336855473946637 0.38878066573106 2.2313094673192653e-15 1.7384393159808808e-06 8.796288776465451e-06 2.1011821679685627e-14 4.738172325786282e-14 +Cytochrome complex 9 18 3.709634279541177 0.0002075588513652 6.021844660194175 16.08495145631068 1.0267019648816196 0.2321293206617183 2.9315837025395948 1.6175814223208935 1.624269406530766 0.2919563386676546 7.923345602046792e-08 9.418757649753928e-06 2.684369985471731e-07 1.5734925202142336e-08 5.774222394391529e-07 +Golgi cisterna 12 22 3.5579001189459936 0.0003738314007111 8.524271844660195 22.490291262135923 0.9086972174309816 0.318868202549777 4.2525712614684625 5.269200019661922 1.391079392561209 0.3149122340418913 4.343354331998693e-06 0.2922756805728106 0.033011066423499 0.0003558175935407 4.220262440537482e-05 +Endoplasmic reticulum golgi intermediate compartment membrane 20 26 3.48996909475851 0.0004830764096546 10.49271844660194 25.839805825242717 1.5441023898993702 0.2324243418613106 5.505729177420246 3.7718384126099376 1.49831312620529 0.2965572765953523 1.389328355538598e-07 1.0 0.0978881295505725 4.681516685660092e-05 2.332455145656504e-07 +Azurophil granule 30 67 3.459230290975433 0.0005417215147718 20.46359223300971 67.00485436893204 0.4795255752980384 0.3097891700346699 6.177875864944045 5.290582926033595 2.1760997104513735 0.3628132485163926 1.1635109493061787e-11 0.1018269830303097 0.0246695053344801 6.375257885270477e-07 4.485825619871452e-12 +Golgi cisterna membrane 9 16 3.357740230915061 0.0007858242549778 6.233009708737864 17.101941747572816 0.7930989258143627 0.3092897028410761 3.2184356191878685 3.952300069740005 1.3504727992091758 0.2953094162507478 2.7869167477218715e-05 0.2180755491779121 0.0890100643743446 0.0002314913891327 0.0001665225081846 +Golgi stack 12 31 3.3368483575352825 0.0008473416633996 9.67233009708738 31.25242718446602 0.7055900861920908 0.4265468940333196 4.557817503574521 5.847941213698429 1.2226912303929196 0.3463938041520717 0.0001111600533469 0.3716550187930373 0.0681614338573012 0.0024873657620056 0.0008689936972513 +Outer mitochondrial membrane protein complex 12 15 3.2973577596537926 0.0009759909578079 7.157766990291262 15.730582524271844 1.3245491566248977 0.2112996285983387 3.5767402396348245 0.8689557679680192 1.477430451036954 0.2853006280851536 1.004293635232441e-09 0.0039064712270754 0.0008717411361388 2.591400071592553e-07 3.572406935806625e-10 +Azurophil granule membrane 9 20 3.217909216729594 0.0012912868138976 7.856796116504855 21.259708737864077 1.0757479237162697 0.2373572682944545 3.393508570011604 2.63895903142419 1.639408148995933 0.2881313440808664 8.863824293321637e-06 0.019691222561341 0.0720571885403784 0.0001047370599813 5.575737006440399e-05 +Exocytic vesicle 15 42 3.185028266598605 0.0014473986973193 12.106796116504857 38.40533980582524 0.7408080162244459 0.4227017753873355 4.952517495270036 4.6543925000719675 1.3317240485888555 0.365166844745196 0.0002784321030928 0.134200446091197 0.1426674419185315 0.0004409264559267 0.0008905418916484 +Late endosome 22 64 3.1673957778325814 0.0015381083161902 15.655339805825244 65.18203883495146 0.1482522199608934 0.3683478922291265 6.675389202214119 9.543379127098556 1.7080817701484334 0.368772234437858 0.0011624631005378 0.2512059527024609 0.5898982141989131 0.0603453375335773 0.0051116973979048 +Nuclear inner membrane 15 22 3.056389496165329 0.0022402003861996 7.347087378640777 20.57281553398058 1.3204335588742686 0.2519451141048848 3.6006224195129035 1.9968516080603145 1.2188770932171689 0.2896682474252494 0.0011146167435126 0.1801156574188796 0.0614247268920475 0.0032221742646108 3.434320745486082e-06 +Golgi membrane 72 133 3.028966144542471 0.0024539218088857 41.28398058252427 131.19174757281553 1.6327747521284677 0.3511039607499193 15.277988344159814 17.44963987873233 1.926180921267262 0.4033858283713009 9.112531512513476e-10 0.0484671438133596 0.0002029735908402 3.895043154169477e-06 1.4463042658942608e-09 +Endoplasmic reticulum protein containing complex 30 58 3.0285650541458424 0.0024571816713452 20.067961165048544 61.213592233009706 0.544324442160867 0.4875881372361492 7.672624563199495 5.300944201362535 1.5348103009085623 0.3893079894443684 0.0010438271265879 0.0916019579859948 0.0855550276988868 0.2636844736780806 1.5976248571908937e-05 +Organelle membrane contact site 10 14 2.9611788414997435 0.0030646392666013 6.817961165048544 16.400485436893202 0.815819301321945 0.3904411977369264 3.451940177462974 2.047328298639296 1.2919706717077657 0.3464717655445403 4.845604953666517e-05 0.1524760813950871 0.2872333566147377 0.2064377407436189 0.0002147363626889 +Respiratory chain complex iv 4 11 2.9509896026715965 0.0031675757965068 3.754854368932039 9.74271844660194 0.8119042784517004 0.2590637228606872 2.032646352020888 1.0643473720992946 1.3870085883810457 0.2875864020654643 0.000508394757649 0.0031646532309382 2.214575962840231e-05 5.200397996359343e-05 0.0013369974246366 +Secretory granule membrane 20 70 2.938639409274076 0.0032965636406274 19.699029126213592 69.8495145631068 0.9295860214656708 0.3887665887416008 7.284889203542463 7.49087955205396 1.5950364553562375 0.3903287060113383 8.05521493727549e-06 0.0531834981275408 0.0301417198148606 7.47395166280678e-06 0.0001808480212595 +Organelle inner membrane 113 244 2.9074930750925483 0.0036433841094398 79.6747572815534 237.5995145631068 1.5941979045672914 0.3906136455525962 32.81710191865129 21.467005610038825 2.570753705211445 0.4244355950981394 1.1383001117015178e-33 7.18909174359896e-07 5.630253104757104e-15 2.1205388748087264e-25 1.7665662088529005e-37 +Proton transporting two sector atpase complex 9 21 2.893124043355881 0.003814306250115 7.116504854368932 22.25728155339806 1.0735578367707936 0.2848832687688338 3.2910616544032156 1.9833825153714253 1.32099194967518 0.2987458873835026 3.869022304188862e-05 0.0110614955842043 0.0002983067426918 0.0001415457384854 2.4597593044142757e-05 +Respiratory chain complex iii 4 8 2.788966765342035 0.0052876490868465 2.5145631067961167 7.186893203883495 0.8648567981956616 0.2640480169416735 1.5224155414895728 0.9433070612984726 1.3007640218760226 0.2795290338624424 8.985506357909055e-05 0.0016377422378922 0.0066572828402184 0.0001991597833083 0.0002457979454447 +Mib complex 8 10 2.755734801867423 0.0058560456089586 4.669902912621359 10.016990291262136 0.8674199579421746 0.3102009046029466 2.3929035436504367 0.6011337749949848 1.2568635951567688 0.31203902687269 1.8990817200445957e-07 1.0 0.1180585699575878 8.624555272386569e-06 3.028938715404879e-08 +Vacuolar membrane 34 114 2.734439308547965 0.0062486613644772 31.91504854368932 121.20631067961163 0.8693310080509177 0.3422944242486927 10.598363436017626 13.850227259030053 1.9844114292962869 0.3837860427998523 1.2289334900035997e-07 0.0204939235568812 0.0050240240300603 2.116619821521985e-05 6.649987305843721e-06 +Endoplasmic reticulum golgi intermediate compartment 25 50 2.720815067799817 0.0065121181382787 14.888349514563108 49.49271844660194 1.4759277407874345 0.3201471070907981 6.47003250199477 5.053350843348441 1.420924643396655 0.3585240832471577 5.727703629085252e-06 0.0775813155222107 0.0145704521374391 0.0001210853397411 1.7675395699865103e-05 +Apical plasma membrane 20 48 2.6978368986877785 0.0069791625539854 13.313106796116504 44.91504854368932 0.8056122914935105 0.4638533528605782 6.08368206230376 5.803837594461636 1.1490032654706197 0.3657186109722784 0.0923632039278187 1.0 0.7851702278936415 0.3337154193623201 0.1458339869175705 +Endoplasmic reticulum lumen 23 58 2.6739413005708657 0.0074965571854646 18.07766990291262 59.737864077669904 0.9896277047863468 0.3946249358858228 7.513340007333169 6.273245958458151 1.4320597420402308 0.3846324865730224 0.0009752184023971 0.1888134882908049 0.2216305912196411 0.22400409765679 0.0001960111476453 +Intrinsic component of mitochondrial outer membrane 8 11 2.670257973241879 0.0075792990480132 5.004854368932039 12.186893203883496 0.537559322132711 0.4142348023165385 2.5976045215999015 2.144426747635188 1.2224430201503769 0.3320793466689031 0.0016982309129601 1.0 1.0 0.0172025832638257 0.0042957165481444 +Intrinsic component of golgi membrane 10 11 2.663902370956553 0.007723997591355 4.655339805825243 10.08495145631068 1.3178763872097854 0.2129685736028588 2.6046347098798024 1.9780511021437377 1.2704958978874823 0.2699640456705705 0.0011146167435126 1.0 0.0614247268920475 0.0032221742646108 0.000798592209508 +Lipid droplet 14 31 2.654833600052021 0.0079347538800336 7.313106796116505 30.72087378640777 0.9597061621709796 0.3916106255858687 3.663189105886808 2.181620314734523 1.1934081113966928 0.3497541884861006 0.0040987669954756 0.0384617608576108 0.0036673828223822 0.0050344975307554 0.0140935967091553 +Membrane microdomain 27 66 2.6361806910798804 0.0083845070718056 14.75485436893204 63.49029126213592 0.5762129399877682 0.5023556315347317 6.545256989336744 6.436953608643344 1.167657055169838 0.3823949317010994 0.0093734989700566 0.0628751933518709 0.2861808409488877 0.0191549269702723 0.0133053849805054 +Copii coated er to golgi transport vesicle 19 35 2.635356786025525 0.0084048885323739 10.810679611650484 32.4247572815534 0.9209697551014924 0.3949407296339237 5.01338814607213 3.9617918728777735 1.2509556054930144 0.3456813773327062 0.0044994144326861 1.0 0.4775398588675821 0.0225481074784796 0.001360170383234 +External side of plasma membrane 12 24 2.630428515671052 0.0085277301863266 6.856796116504855 22.03640776699029 0.7617836494895279 0.3205100812766187 3.0547396608098576 3.343757364022431 1.3549821177336052 0.303342613906597 0.1225623930092731 1.0 0.271213554068588 0.2530547699696884 0.2554949002325081 +Proton transporting two sector atpase complex proton transporting domain 4 11 2.587522741306885 0.0096668814380957 4.053398058252427 10.283980582524272 1.020958321179617 0.2307004649223604 1.8491832641634656 1.1862626633334956 1.3576055733210162 0.273185751006507 1.3003828622724358e-05 0.0021914548918381 1.0100053103379697e-05 1.934192081629664e-05 4.367834065541858e-05 +Transport vesicle 42 96 2.566088712688151 0.0102852519348932 26.046116504854368 92.34708737864078 0.9512017428916244 0.4458616213657612 9.46815354334768 9.09007867686459 1.424803887648301 0.3967491654773343 1.2315189140609296e-06 0.348957119320241 0.106384805735638 0.000580872456499 9.499492155615844e-06 +Synaptic vesicle membrane 8 17 2.5627188161308454 0.0103856120913157 5.099514563106796 14.07766990291262 0.7734258277348643 0.4227625879426745 2.579286376297321 2.2325453295101236 1.0485572818049853 0.3297289695807819 0.0903505899113914 0.2507644527164699 0.1163398228410075 0.0593060830293246 0.0744808849197366 +Organelle envelope lumen 13 38 2.546333644966001 0.0108861084551155 11.436893203883496 36.55339805825243 0.6276066761486734 0.4428242266058088 4.702137301503097 3.7796803567009714 1.1382138566471218 0.3469405856623805 0.000988883953264 1.0 0.5351022899588459 0.0028924350901622 0.0014287535135353 +Cis golgi network 6 15 2.5165185320703185 0.0118520667007346 5.446601941747573 14.91747572815534 1.304763677188147 0.2415633778835601 2.9087352716231463 3.2280604409731746 1.23405443481851 0.2890539664507128 0.0038189986913047 1.0 0.0538434207197609 0.0140312853386763 0.0024204837857025 +Snare complex 9 17 2.511445981060372 0.0120237686440236 6.20873786407767 15.79368932038835 0.8138466711937282 0.3737991711938105 3.1112263618988054 3.010283181947674 1.1802712183474584 0.3261149602927671 0.0062571979838837 0.1839914155878272 0.0080456420559546 0.0005352167677164 0.0042906431799932 +Proton transporting atp synthase complex 5 11 2.49503326910902 0.0125945321086289 4.157766990291262 11.08495145631068 0.5328143574617974 0.3012358599713604 2.3610641964760792 1.138499586439592 1.3748267965121657 0.2836171984539964 0.0003792915561059 0.0028214739728005 0.0005309775927247 0.0073447144383531 9.937036022358197e-05 +Phagocytic vesicle membrane 12 24 2.4686333513885232 0.0135630106737241 7.512135922330097 23.83009708737864 0.5348434256443761 0.4468744105904624 3.681144332021715 3.0024693704800938 1.1652764437248655 0.3385441964418395 0.0024903141153664 0.2507644527164699 0.1163398228410075 0.0593060830293246 0.008913025090531 +Late endosome membrane 11 34 2.468084297559373 0.0135838326203001 8.400485436893204 35.220873786407765 -0.1907871949509251 0.3412955054288843 4.360825137615114 6.285848739997517 1.5677242851178623 0.3272837423268039 0.0503130706966557 0.1123544518992548 0.3281099840481742 0.172108822769145 0.0724526193914442 +Transporter complex 22 52 2.4646372029756964 0.0137152042919643 16.033980582524272 55.199029126213595 0.256193630237002 0.358562058071074 7.704418772430675 7.665912382074106 1.666161547187811 0.3440522205931707 0.000690364252312 0.1536302836663208 0.0540831694948363 0.0030848714002588 0.0002882025351099 +Basolateral plasma membrane 19 45 2.464633138348852 0.0137153598583574 11.907766990291265 41.713592233009706 0.4173504135492652 0.5464661760255546 5.696723454799589 5.533263026209871 1.098008793343998 0.3512755123780914 0.0147749464293866 1.0 0.6727295364723632 0.3014727885764127 0.0037398270299088 +Mitochondria associated endoplasmic reticulum membrane 5 8 2.4639359666909013 0.0137420659377947 4.191747572815534 9.240291262135925 0.7019541594808174 0.4009163152547425 2.0831338076447135 1.0418560326821893 1.1194321867771957 0.3336055532093068 0.0046090980714051 1.0 1.0 1.0 0.0097510399506001 +Basal part of cell 24 52 2.45849498205875 0.0139520726309354 12.87378640776699 49.39563106796116 0.4231791430151931 0.5418083225496748 6.317535484281435 5.887808725837185 1.1575518486276402 0.3620095959132046 0.0217119297238114 0.485826119705386 0.3906542776432947 0.2494349853620711 0.007998844151367 +Endocytic vesicle membrane 17 42 2.436991740696823 0.0148100176281282 11.41019417475728 40.75728155339806 0.6528171904926832 0.3529092384633215 4.825015011915381 4.780047567333447 1.5638167276319088 0.3380752375601685 0.0004666842134923 0.0988733586390047 0.0948939281427919 0.0059466548235716 0.0032083814479727 +Autophagosome 18 33 2.4265535098497217 0.0152430022843008 7.490291262135922 28.23058252427185 0.2382857558920592 0.551676712271876 3.4770262532301657 5.388565442188036 0.9533210099421008 0.3228297396792804 0.0034137263336624 1.0 0.5943645192903619 0.0740089890485984 0.0052453150917069 +Autophagosome membrane 8 16 2.3799890945583795 0.0173131504168211 4.174757281553398 13.37135922330097 -0.0098942360451326 0.445924723627937 2.326200220393679 3.0901432865083773 1.1383635180898088 0.3067757682348186 0.0070114738153001 1.0 1.0 0.0893115916137597 0.0048940429574069 +Specific granule membrane 3 17 2.332499540061096 0.0196744270853252 4.703883495145631 15.434466019417476 0.8701513897757543 0.3699585460258285 2.477017558764293 2.6655071934549124 0.9998631482292508 0.308737972868479 0.1248821536309092 0.0221752921749746 0.0803922289273931 0.0300192966842153 0.2132278663521486 +Pigment granule 27 60 2.3257450301159577 0.0200321567054861 17.058252427184467 60.37135922330097 0.3452760243889364 0.5728855837677844 7.454164461546019 2.3255555964379067 1.200064167427868 0.3798846852248331 0.002681354552683 0.3472525306689195 0.2142764757579067 0.0214585441311225 0.0001013550764048 +Synaptic membrane 16 45 2.304856243245556 0.0211746259301544 8.0 43.851941747572816 -0.310086222058418 0.4988278056428725 5.299752696190333 6.073571678069297 1.0036604043689128 0.3214862568269108 0.177144668887689 0.5327909523059658 0.7893446820396504 0.7465625425106264 0.0889178289701022 +Postsynaptic membrane 11 32 2.293097908569833 0.0218423687759794 4.861650485436893 30.723300970873787 -0.6441624692071726 0.4459394327354834 3.6213746778607736 4.275255147861873 0.9932092680715762 0.3211717809707486 0.1270141957611662 0.3980408639782044 0.6461396159450896 0.7344217404793858 0.0347305706128729 +Endoplasmic reticulum tubular network 5 11 2.270945780537472 0.0231502603967836 4.456310679611651 11.402912621359222 0.7597390036291544 0.4204688348420043 2.5600618129260964 1.9933849978482647 1.110800197793671 0.3406591463359876 0.0097364536063123 1.0 0.191600110602388 0.0152248647419399 0.0034992238505004 +Acrosomal vesicle 6 19 2.2616001289802363 0.0237221200422925 3.495145631067961 18.155339805825243 -0.9791893532974586 0.3081609046970277 2.38369781433254 2.1156250955039684 1.1440240331237563 0.2794556585030013 0.0087139040293847 0.1955113655682517 0.3593428278464597 0.0244406528674846 0.0062896490617296 +Oxidoreductase complex 16 61 2.259206310328169 0.0238705544858228 16.138349514563107 58.1747572815534 0.4112275970760134 0.4385210691837483 8.292749505639035 5.03902669070441 1.4297411393453454 0.366860872580609 9.474511579872844e-06 0.0121384722608551 0.0029560859975957 3.3133712910075926e-05 7.290650337771797e-06 +Micos complex 4 5 2.2544296185611885 0.0241691537328343 2.4927184466019416 4.725728155339806 0.7557668283408772 0.3464970141803932 1.2077602589329477 0.4877312285913208 1.1862461875397572 0.3249829583805667 0.0001440761934787 1.0 1.0 2.1451255431067108e-05 1.3106068439724131e-05 +Cell surface 29 77 2.235224270186246 0.025402628892954 21.233009708737864 77.5995145631068 0.4772545566224628 0.498248600191797 7.455308766626032 8.832436895439663 1.3320096182828691 0.3812427248674431 0.3541173374306318 0.7790597040560163 0.5876455513518505 0.3501792188017755 0.5692683997576649 +Proton transporting atp synthase complex coupling factor f o 3 7 2.216605272637638 0.0266500769589426 2.388349514563106 6.79126213592233 0.5842994650422648 0.284211882186535 1.5103719705721683 0.8950355849210965 1.3255228108854136 0.2674401609228611 0.0004059252135544 0.0009534063593398 9.839858993160587e-05 0.0014684283121974 0.0009118158302113 +Recycling endosome membrane 14 23 2.2145027100147856 0.0267942164904801 6.888349514563107 22.509708737864077 0.1536767921278238 0.6101735952601732 3.1901182670006487 3.1100218387491214 0.9055004805495972 0.3161343906862945 0.5596779569360734 0.2956314809635333 0.1588529428511447 0.5365210756997536 0.7039869744144245 +Mitochondrial envelope 132 317 2.1901062922850687 0.0285165290046867 98.51456310679612 309.05582524271847 1.3784407074331837 0.4315621435689855 37.853540978552445 29.592036616547553 2.6690149272426917 0.4358105924461398 1.6907254970133367e-37 2.2204547547940797e-11 3.012375200041382e-17 5.0001905213485594e-30 2.8875273227701395e-37 +Transport vesicle membrane 20 47 2.189946318474308 0.0285281302350857 12.62135922330097 42.37378640776699 0.5402420874587609 0.5343084089707166 5.404271063272784 4.511161156897919 1.052801184280702 0.3556606283757049 0.0302316314458245 0.4580565166404663 0.3526837640973719 0.0918582333412919 0.0227314048616643 +Intrinsic component of synaptic vesicle membrane 6 11 2.160383515779534 0.0307429924822193 3.648058252427184 9.116504854368932 0.724313202500786 0.4129003553732678 2.1933086936710184 1.7154408466980504 1.018214829869002 0.3297596143558817 0.0875376569601171 1.0 0.2297987482657219 0.1374615323876937 0.0397044670530444 +Intrinsic component of nuclear inner membrane 6 7 2.135255922427994 0.0327401112046903 2.4344660194174756 6.461165048543689 0.7221555748366164 0.3746407047127702 1.5973511010756076 0.8763043548183138 1.0289148549650529 0.2984963891905157 0.0282844660019362 1.0 1.0 1.0 5.11944457815466e-06 +Postsynaptic specialization membrane 5 12 2.120838493344445 0.0339353961152535 2.4199029126213594 10.24271844660194 0.7861101002372709 0.3813630835285081 1.6578416165380507 2.0900412009571863 0.9115241808638076 0.2917173074219844 0.2165131980217589 0.1762218760282218 0.327507803675052 0.260178364686727 0.0469837238449897 +Dendrite membrane 3 5 2.0881935177177526 0.0367803818209884 1.194174757281553 2.95873786407767 0.6293756218752072 0.4097570734278496 0.9981366370186608 1.0407924348542348 1.1008690326046948 0.3120718756484198 0.3299438772132937 1.0 1.0 1.0 0.0105668672564949 +Side of membrane 28 69 2.0788479188418028 0.037631330923052 17.526699029126213 71.19660194174757 0.4235531336200628 0.5236659753791312 6.9409272887607125 8.635706418493163 1.198097658489356 0.36822581052137 0.0360930675025588 1.0 0.2176447961979714 0.2536228856800087 0.0980355574513218 +Azurophil granule lumen 17 43 2.0696372173985904 0.0384863300884792 12.118932038834952 41.25728155339806 -0.033426136567579 0.3776020138210581 4.31782609196223 3.0753988435553 1.7699755963815147 0.3570217435028845 4.900312824755131e-06 1.0 0.1226746045160812 0.0039966852967412 2.2433185125402162e-07 +Early endosome membrane 23 42 2.060630472236951 0.0393383073362145 12.29611650485437 44.95873786407767 0.5277524243262064 0.5849546522697281 4.982462882428341 7.094079738701261 0.90392558948614 0.3412735259006035 0.0547464153679979 0.4449535115530259 0.7002848572935141 0.1802028808367961 0.1483645143725162 +Nuclear outer membrane endoplasmic reticulum membrane network 132 301 2.0179295868848968 0.0435985951510955 98.3519417475728 305.0218446601942 1.8626549185660248 0.4346737740195964 40.114822105305365 33.029069404441934 2.648813561163414 0.4525721946789457 4.630899324899059e-25 0.000144385357811 0.0002686629887871 1.3008205576335947e-14 7.811725978848469e-31 +Golgi apparatus subcompartment 36 90 2.0169927706754582 0.0436962677512366 23.898058252427184 88.56796116504854 0.6438651907142603 0.5157075238910589 9.044082768463602 13.85685287398648 1.2182273227220288 0.3801323692583779 0.001089714314127 0.7290395724580129 0.0475550848087982 0.015072680493098 0.0035272396581226 +Microbody membrane 9 24 2.011427869990674 0.0442802820121179 9.83980582524272 26.8373786407767 1.0322166739723002 0.3740701224912098 5.101262737371427 4.075770333088885 1.3138416014090577 0.3534887732287703 0.0235975326106129 0.236404668572991 0.4242240140575919 0.7524126639072135 0.005918859062877 +Lumenal side of membrane 4 9 2.009587563567873 0.0444748585911105 3.686893203883495 9.509708737864075 0.6270696996832885 0.3351332813726532 1.8490414883089543 0.9791034697552432 1.2332692274886168 0.3003490996154719 0.0013726902925657 1.0 0.191600110602388 0.4160065505344545 0.0034992238505004 +Pore complex 2 8 2.0091297467650526 0.0445233757089875 3.2111650485436893 8.830097087378642 1.029129610796519 0.2182996080526768 1.893158762220583 0.772882004264421 1.343874754683687 0.2717215815078918 0.0270625432516923 6.357667188483331e-05 0.0005309775927247 0.0073447144383531 0.0465653262864464 +Tim23 mitochondrial import inner membrane translocase complex 3 5 2.005453629668162 0.0449145732802234 2.2694174757281553 6.342233009708738 1.5180442383336388 0.125307709046494 1.369833329272529 0.8106469094037756 1.2674744491900518 0.2021471972412396 0.0668156138205414 0.0506073598520519 0.0047533286028597 0.0276231155809849 0.0140126286640228 +Postsynaptic density membrane 4 9 2.001970903325747 0.0452878609837137 1.8106796116504855 6.669902912621359 0.9700827983290172 0.2992953748741365 1.3610684424812354 1.822930264123012 0.935271302642404 0.2569047527325972 0.4016294987042966 0.1524760813950871 0.2872333566147377 0.2064377407436189 0.087821349317486 +Integral component of synaptic vesicle membrane 5 6 1.987263236434816 0.0468932334241782 2.2475728155339807 4.910194174757281 0.8567274645780141 0.3149754325120096 1.3818760752746044 1.4445051429216968 1.1133243513780926 0.2989777184888048 0.0270625432516923 1.0 0.1515272625734178 0.0621585272883563 0.0078812527225172 +Sarcolemma 11 28 1.9738764889963445 0.0483957887361548 6.849514563106796 24.82766990291262 0.1401032497752024 0.6240915375619693 3.1177030936067345 2.404871957871013 0.82647351967221 0.3084890241561867 0.052972134925655 0.2786952299090933 0.4876012483283494 0.0849374332498421 0.0492141807689911 +Intrinsic component of presynaptic membrane 3 5 1.967074745429088 0.0491745942789421 2.1529126213592233 4.754854368932039 0.3133963453989226 0.4445007611399023 1.2803277273621594 0.9007013061327611 1.0351014517698869 0.3027308229331067 0.0593556147738179 1.0 1.0 0.4301270919610729 0.0233101974365333 diff --git a/msigdb_gocc/metrics.json b/msigdb_gocc/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..539c4387e1233443548626963e0ba701f83b9872 --- /dev/null +++ b/msigdb_gocc/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3120, + "annotations_size": 906, + "title": "Average number of proteins per term", + "value": 28.508830022075056 +} \ No newline at end of file diff --git a/msigdb_gocc/paths.json b/msigdb_gocc/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..0d3d434638385f1ce2ef72641a1531de39784181 --- /dev/null +++ b/msigdb_gocc/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gocc/fragment/C390/C390_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gocc/result.tsv b/msigdb_gocc/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..919c9ef3fb72ebd0efdeba1c850e9f6b3f84ff93 --- /dev/null +++ b/msigdb_gocc/result.tsv @@ -0,0 +1,307 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Inner mitochondrial membrane protein complex 0.6970964549951727 4.806948710013415 1.5325128701615398e-06 0.0013874942628162 0.000679871021067 76 Q5XKP0,Q9P0J0,Q9UDW1,Q99623,Q3ZCQ8,O14949,O60830,Q9NVH1,O75964,P13073,P14406,P24539,Q9BUR5,P14927,O95169,P35232,Q86Y39,Q53H12,Q96CU9,P09669,P21912,O96000,Q13505,Q9NX63,Q96IX5,O14925,P00846,Q9Y512,P20674,Q6UXV4,O75306,P06576,P22695,Q9Y6M9,Q16891,Q9NX14,P56385,P00403,Q8NE86,Q9BPX6,O75431,Q9Y276,O95168 43 +Lysosomal lumen 0.834122379773528 4.684448218482023 2.807151204375913e-06 0.0025400511578018 0.000679871021067 33 O14773,P04062,P11117,P06280,Q14108,Q13510,P50897,Q9UM22,O00584,Q8NHP8,P17900,Q9NZJ7,P10619,P08236,Q9UMR5,P13473,P38571,Q8IV08,P04066,P16278,P15586,P54802,P38435,P06865 24 +Intrinsic component of mitochondrial membrane 0.7718427387627207 4.649874327969697 3.321373491349533e-06 0.0030046463682479 0.000679871021067 46 Q5XKP0,Q9H9B4,Q16134,Q9UG56,Q9H9P8,Q9Y6N1,O75880,Q9Y2R0,O60830,Q9NVH1,P50416,Q9BUR5,Q9BWH2,Q53H12,Q13505,O14925,Q9NX63,Q9Y512,P12235,Q6UXV4,Q9GZY8,Q15070,Q16891,O43819,Q8NE86,Q9BPX6,Q15388,Q6P4A7,O75431,Q9BUB7,Q9H3K2,Q9HC21,O95140,O96008,P57105 35 +Intrinsic component of plasma membrane 0.676664080025505 4.604294394264732 4.138666670705504e-06 0.0037426186420435 0.000679871021067 78 Q15375,P41440,P20020,O15118,P35613,Q02978,P11279,P55011,O60637,A0FGR8,Q8TDW0,P10586,P16615,P05026,P35232,Q92542,O43657,P23634,Q8TAD4,Q9UJS0,Q12907,Q9UIQ6,P78310,Q9NY64,Q8NHP6,Q9H0U3,O43464,P04439,P12235,P10321,Q99805,Q9NR28,P27824,P05023,Q08722,P30825,Q15043,P11717,P05556,O00560,P51572,P35670,P05141,P20645,Q13641,P01889,O96005,Q8WTV0,Q15758,O15031,P54709,P51790,P02786,O00264 54 +Intrinsic component of organelle membrane 0.7293777855236949 4.586728438817639 4.502457093158441e-06 0.004070926531005 0.000679871021067 129 Q8N4V1,Q9H9B4,Q16134,Q15006,O94901,Q9H9P8,Q9NZ01,Q9Y2R0,O43808,O60830,O75298,Q9NVH1,Q96S52,Q13505,O14925,P12235,Q9NQC3,Q9Y4W6,Q15070,O60499,O15258,Q9Y282,O75844,P42892,O43505,O95470,P57105,Q96A33,Q8TB36,Q5XKP0,Q9Y679,O15118,Q9UH62,Q86YN1,P50416,Q9BUR5,Q969X5,Q9BWH2,Q53H12,Q96NB2,Q5J8M3,Q5BJH7,P04439,Q6UXV4,Q10471,Q14739,Q8TB61,Q86Y82,Q16891,O15126,O95070,O43819,Q12981,P61020,P01889,P13473,Q5H8A4,O76024,Q8TCT9,Q9UG56,Q86XL3,Q9NPA0,O75880,Q15041,P98194,Q5SNT2,Q9Y2U8,Q15629,Q9Y512,P10321,P27824,Q9P035,Q9GZY8,L0R6Q1,P51572,Q9BPX6,Q15388,Q6P4A7,O75431,Q9H3K2,Q9HC21,Q9BUN8,P20020,Q9UM00,Q92643,Q9Y6N1,Q99442,O43752,Q8NC56,Q9NX63,Q9UH99,Q9BTV4,Q8NE86,Q9Y4P3,Q6ZRP7,P57088,Q16799,Q9BUB7,O95140,O96008 100 +Vacuolar lumen 0.6407599693552284 4.4337529975971846 9.2606718804511e-06 0.0083551080144593 0.0011985955319556 64 O14773,Q92820,Q9H7Z7,P04062,P11117,P06280,Q96CS3,Q14108,Q13510,Q9BTY2,P50897,Q9UM22,O00584,Q8NHP8,Q13217,P17900,P07437,O00560,Q9NZJ7,P10619,P08236,Q9UMR5,O43681,P38571,P13473,Q8IV08,P10253,P04066,P16278,P15586,P54802,P38435,P06865,P68371 34 +Intrinsic component of mitochondrial inner membrane 0.7841371638113717 4.331653235675882 1.4799389415065534e-05 0.0133188545803112 0.0016760308512562 32 Q5XKP0,Q9H9B4,Q16134,Q9UG56,Q9H9P8,Q9Y6N1,O75880,Q9Y2R0,O60830,Q9NVH1,Q9BUR5,Q53H12,Q13505,Q9NX63,O14925,Q9Y512,Q6UXV4,Q15070,Q16891,O43819,Q8NE86,Q6P4A7,O75431,Q9H3K2,Q9HC21 25 +Intrinsic component of endoplasmic reticulum membrane 0.6701055310692681 4.134634304761335 3.5552029530316887e-05 0.0316974717375989 0.0032210138754468 53 Q8N4V1,Q15006,Q86XL3,Q9UM00,Q9NZ01,Q9NPA0,Q92643,Q86YN1,Q15041,O75298,Q99442,Q15629,P10321,P27824,Q9P035,Q9NQC3,Q8TB61,P51572,Q9Y282,O75844,Q12981,Q9Y4P3,P57088,Q16799,O95470,Q5H8A4,Q9BUN8,O76024,Q8TCT9,Q96A33 30 +Respirasome 0.6795776119739406 3.950197865112416 7.808661294084196e-05 0.0683044992789438 0.0064314973931276 46 Q9P0J0,Q9UDW1,O14949,Q7KZN9,P13073,P14406,O95169,P14927,Q86Y39,Q96CU9,P21912,O96000,P20674,P22695,Q9Y6M9,P00403,Q13423,Q9Y276,O95168 19 +Outer membrane 0.6128912354782079 3.8738277858280226 0.000107139136408 0.092510477034203 0.0080890047988063 91 Q99720,Q5XKP0,Q8N4H5,Q9NS69,Q9NZ45,Q99623,Q9Y277,P21796,O43169,P50402,P50416,Q9BUR5,Q9BWH2,Q53H12,P45880,Q13505,Q96B49,Q9Y512,Q6UXV4,P52789,Q9GZY8,O60313,Q16891,Q96TC7,P30536,Q9NZJ7,Q07820,Q15388,Q9Y6C9,O75431,Q9NQZ5,P09601,P57105,O00264 34 +Cytochrome complex 0.838976488550947 3.709634279541177 0.0002075588513652 0.1714415020808313 0.0144652553336092 18 P13073,P20674,P14406,Q9Y276,P22695,Q9UDW1,O14949,Q7KZN9,P00403 9 +Golgi cisterna 0.7585924646693427 3.5579001189459936 0.0003738314007111 0.287342665979191 0.0225794166029518 22 P98194,Q10472,Q8NBN3,Q15363,Q8TBA6,Q96JB2,O95249,P51572,Q10713,Q9H4A6,Q96L58,Q11206 12 +Endoplasmic reticulum golgi intermediate compartment membrane 0.7170645229166489 3.48996909475851 0.0004830764096546 0.354527695141985 0.0273542016966926 26 Q15363,Q96GC9,P61019,Q9Y3A6,Q13190,O15260,Q10472,Q969X5,Q12907,Q5BJH7,P24390,Q15904,Q9H0U4,P51572,Q9Y282,P49755,O95070,Q9BVK6,O75396,Q9Y3B3 20 +Azurophil granule 0.5430059400352663 3.459230290975433 0.0005417215147718 0.3879447230834973 0.0286093649912083 67 O15400,Q92820,Q9H7Z7,P11279,O15260,P06280,Q96CS3,Q8NF37,Q07065,P02792,Q9BTY2,Q92542,P42785,O00584,Q13217,P17900,P07437,O00560,O95721,Q9NZJ7,P10619,P08236,O43681,P13473,P10253,P04066,P16278,P15586,P06865,P68371 30 +Golgi cisterna membrane 0.8120670618868713 3.357740230915061 0.0007858242549778 0.5094542136709658 0.0374714092110497 16 P98194,Q10472,Q8NBN3,Q15363,Q96JB2,Q9H4A6,Q10713,Q96L58,Q11206 9 +Golgi stack 0.6526369963610642 3.3368483575352825 0.0008473416633996 0.5360678562666172 0.0383845773520025 31 P98194,Q10472,Q8NBN3,Q15363,Q8TBA6,Q96JB2,O95249,P51572,Q10713,Q9H4A6,Q96L58,Q11206 12 +Outer mitochondrial membrane protein complex 0.8175929312410319 3.2973577596537926 0.0009759909578079 0.5871535709551192 0.0421070384654301 15 Q15388,Q6UXV4,Q5XKP0,Q8N4H5,Q9BUR5,O75431,Q9NS69,Q16891,Q13505,O96008,Q9NX63,Q9Y512 12 +Azurophil granule membrane 0.7174037607697314 3.217909216729594 0.0012912868138976 0.6898384059736569 0.0508654718865779 20 Q8NF37,P13473,Q07065,Q92542,P42785,O95721,P11279,Q9NZJ7,O15260 9 +Exocytic vesicle 0.5987979320391814 3.185028266598605 0.0014473986973193 0.7307979738659856 0.0546393008238057 42 Q9BT78,O15400,Q96A57,P20020,P50897,Q9GZY8,Q92542,O60499,O43760,O76024,P11279,P51790,Q15907,Q9UI14,Q9NY64 15 +Late endosome 0.5109777331123968 3.1673957778325814 0.0015381083161902 0.7520675457302504 0.0557410453787357 64 Q8IY95,O15400,O15118,Q04656,P11279,O95772,Q14108,Q9Y3E7,Q8IZ07,Q9UQN3,Q9BRK5,Q15043,P11717,P35670,Q9NZJ7,P20645,Q96A57,P13473,Q8IV08,Q9P253,Q9BUN8,P51790 22 +Nuclear inner membrane 0.6799236422596814 3.056389496165329 0.0022402003861996 0.8689135605587384 0.0751711685146995 22 Q8IXM6,Q99720,P20700,O75844,Q5JTV8,O94901,Q03252,Q9H1E5,Q5SNT2,Q9Y2U8,Q9UH99,Q8NC56,Q14728,Q9BTV4,P50402 15 +Golgi membrane 0.5709338199381756 3.028966144542471 0.0024539218088857 0.8920390265813735 0.0767657446289235 133 Q92896,Q7LGA3,P0CG08,Q8N4V1,Q8NBN3,Q9H9S5,Q15363,Q9H7Z7,P61026,Q9UM00,P61019,Q9NTJ5,Q9P2W9,P35613,Q8TBA6,Q16706,Q15392,Q9Y3E0,Q13190,Q96L58,O15260,Q12770,Q8NF37,Q14108,Q10472,Q9BUR5,Q969X5,P98194,O43752,Q10713,Q12907,Q5BJH7,Q8NCH0,P49257,O95197,Q96JB2,P24390,Q11206,P04439,P10321,P83436,Q10471,Q9H0U4,O60476,Q8TB61,Q86Y82,Q8N6T3,P11717,L0R6Q1,O95721,O60499,O95249,O15258,Q9Y282,P49755,Q9H4A6,P51572,O95070,Q8IZA0,P35670,O43505,Q6ZRP7,Q9BVK6,Q8IV08,Q16799,Q9Y371,Q14789,P51790,Q99640,O75396,Q9Y3B3,P52292 72 +Endoplasmic reticulum protein containing complex 0.5243803969668518 3.0285650541458424 0.0024571816713452 0.8923581945206986 0.0767657446289235 58 Q9Y679,P07237,Q8N4V1,Q15006,P46977,P51571,Q9UBV2,Q9NPA0,Q92643,Q15041,O15269,Q96CS3,Q969N2,Q5J8M3,P13674,Q96S52,Q9H0U3,P04439,Q9Y5M8,Q6NUQ1,Q8N766,Q9UGP8,O94888,P14625,O43681,P04843,Q15005,Q9BUN8,Q8TCT9,Q53GQ0 30 +Organelle membrane contact site 0.7767973234790154 2.9611788414997435 0.0030646392666013 0.9380127444271528 0.0876698750313441 14 Q15388,Q96N66,P27824,Q5XKP0,Q9NTJ5,P51572,Q96TC7,O96008,Q9Y320,O95772 10 +Respiratory chain complex iv 0.8323446813257313 2.9509896026715965 0.0031675757965068 0.943548786101402 0.0876698750313441 11 P13073,P20674,P14406,P00403 4 +Secretory granule membrane 0.496373513380751 2.9386394092740757 0.0032965636406274 0.9497939833387036 0.0878437252473084 70 Q15363,P35613,P11279,Q5T9A4,O15260,Q8NF37,Q07065,P30519,Q92542,P42785,Q8TAD4,Q969Q5,P10321,Q08722,O95721,P49755,Q9NZJ7,Q93050,P13473,O00264 20 +Organelle inner membrane 0.6415068288443411 2.9074930750925483 0.0036433841094398 0.96337169156764 0.0943116000900721 244 Q99720,Q9H9B4,Q16134,Q9H2D1,Q567V2,O94901,Q03252,Q9H9P8,Q9UDW1,Q9Y2R0,Q69YU5,O14949,P18031,Q14728,O43615,O60830,O75964,Q9NVH1,Q9BQ95,P13073,P14406,Q8NI60,P24539,P35232,P09669,Q96CU9,Q13505,Q10713,O14925,P00846,Q9H061,P20674,P12235,O75306,P22830,Q9Y4W6,Q7Z7H8,Q15070,Q9Y6M9,Q9UBX3,O75844,P00403,Q9UDX5,Q13423,Q6PI78,Q5XKP0,O75027,Q9P0J0,Q99623,Q9H1E5,Q7KZN9,P23786,P50402,Q9BUR5,Q70HW3,Q8NBN7,Q86Y39,Q53H12,P21912,O96000,Q6UXV4,P22695,O60313,Q16891,O43819,Q8IUX1,Q8IXM6,Q96E52,Q9Y6C9,Q9NVI7,Q9Y276,Q9NPL8,Q9UG56,Q9H300,Q02127,O75880,O95202,Q5T9A4,O43772,O95169,P14927,Q9BQT8,Q5SNT2,Q9Y2U8,Q9UJS0,Q96IX5,Q9Y512,O95831,P56385,P82933,Q9BPX6,Q6P4A7,O75431,Q9H3K2,Q9HC21,O95168,Q6DKK2,Q6NUK1,Q9Y6N1,Q3ZCQ8,O75746,Q8NC56,Q9NX63,O95674,P06576,Q9Y5J9,Q9UH99,Q9NX14,Q9BTV4,Q8NE86,P20700,Q9BUB7,O96008 113 +Proton transporting two sector atpase complex 0.6610471625079302 2.893124043355881 0.003814306250115 0.9686446049619276 0.0953676286737649 21 Q9Y487,P24539,P06576,P56385,Q93050,Q96IX5,P00846,O75964,Q15904 9 +Respiratory chain complex iii 0.87470519983575 2.788966765342035 0.0052876490868465 0.9917975339346116 0.1228361557098195 8 Q9UDW1,Q9Y276,P22695,O14949 4 +Mib complex 0.8186682305331694 2.755734801867423 0.0058560456089586 0.9951129825463806 0.1326394330429144 10 Q6UXV4,Q5XKP0,Q9BUR5,O75431,Q16891,Q13505,Q9NX63,Q9Y512 8 +Vacuolar membrane 0.5246167317990043 2.734439308547965 0.0062486613644772 0.9965831935805852 0.1380801755174721 114 Q9Y487,O15400,Q96GC9,Q16625,O15118,P04062,P11279,O15260,O95772,P11117,Q8NF37,Q14108,Q07065,P42785,Q92542,Q9UIQ6,Q9NY64,O75503,Q15043,O95721,Q9NZJ7,Q93050,P20645,P10619,P42892,Q8WTV0,P13473,Q8IV08,Q8NCG7,Q9Y371,P10253,Q9P253,P51790,Q9Y6I9 34 +Endoplasmic reticulum golgi intermediate compartment 0.5215795040963613 2.720815067799817 0.0065121181382787 0.9973128483820812 0.1404756912685853 50 Q15363,Q96GC9,P61019,Q9Y3A6,Q13190,O15260,Q10472,P80303,Q969X5,Q02818,Q12907,Q5BJH7,Q7Z7H5,P24390,Q15904,Q9H0U4,O15258,P51572,Q9Y282,P49755,O95070,Q9BVK6,Q14789,O75396,Q9Y3B3 25 +Apical plasma membrane 0.5252128594200418 2.6978368986877785 0.0069791625539854 0.9982450054432072 0.1470493319514144 48 P41440,P20020,Q16625,Q04656,P55011,P05026,P08195,P23634,Q8TAD4,P08183,Q86UE4,P05023,P30825,Q15043,P36543,P54709,O75787,P51790,Q9Y6M7,O75955 20 +Endoplasmic reticulum lumen 0.4890634214889806 2.6739413005708657 0.0074965571854646 0.998905509829674 0.1521291699514702 58 Q9NWM8,Q8TED1,Q5JRA6,Q07065,Q02818,Q9BTY2,P13674,O00584,Q13217,P27824,O75718,O14657,O43852,Q8NBJ7,Q14257,Q9BV10,Q9BTV4,O43681,Q9NZ08,Q32P28,O43493,O76024,Q14118 23 +Intrinsic component of mitochondrial outer membrane 0.7767272256557142 2.670257973241879 0.0075792990480132 0.9989851354417816 0.1521291699514702 11 Q15388,Q8TB36,Q9BWH2,Q9GZY8,O95140,P57105,O96008,P50416 8 +Intrinsic component of golgi membrane 0.7754905114184605 2.663902370956553 0.007723997591355 0.9991107283827518 0.1521291699514702 11 O43505,P98194,Q6ZRP7,Q969X5,Q8TB61,L0R6Q1,O15258,Q9Y282,Q5BJH7,O95070 10 +Lipid droplet 0.5635477009349649 2.654833600052021 0.0079347538800336 0.9992664096673034 0.1527903262364401 31 Q01105,Q99720,Q96CS3,Q8NF37,Q9Y679,Q07065,Q8NBX0,Q9H6V9,Q15738,Q9H4M9,P51572,O43760,P48449,P00387 14 +Membrane microdomain 0.4638078538193544 2.6361806910798804 0.0083845070718056 0.9995135558309542 0.1527903262364401 66 O14773,P41440,P20020,O15118,Q04656,P35613,P21796,P05026,P50897,P23634,P78310,P04899,P05023,P07437,Q86Y82,O00560,P05556,O94905,P46108,P05141,P27361,Q8WTV0,P13473,P09601,Q14118,Q9UJZ1,O75955 27 +Copii coated er to golgi transport vesicle 0.5488462235894351 2.635356786025525 0.0084048885323739 0.9995225305370872 0.1527903262364401 35 Q9UBV8,Q15363,Q9Y3A6,Q13190,Q12770,Q969X5,Q9NR31,Q12907,Q5BJH7,Q7Z7H5,P49257,P04439,P10321,Q9Y282,P49755,O95070,Q9BVK6,O75396,Q9Y3B3 19 +External side of plasma membrane 0.6057117332491249 2.630428515671052 0.0085277301863266 0.9995732256719796 0.1527903262364401 24 P08183,P41440,Q5ZPR3,O96005,P00813,P05556,Q14118,P11279,O75787,P02786,P51790,P42892 12 +Proton transporting two sector atpase complex proton transporting domain 0.7607042007048499 2.5875227413068855 0.0096668814380957 0.9998493877047652 0.1684268189022076 11 Q93050,P24539,P00846,O75964 4 +Transport vesicle 0.4906382741835084 2.566088712688151 0.0102852519348932 0.9999144740431604 0.173738072233878 96 Q9UBV8,O15400,Q15363,P20020,P61026,Q04656,Q8TBA6,P11279,Q15907,Q9UI14,Q13190,O15260,Q12770,P50897,Q92542,Q9NR31,O43752,Q12846,P49257,Q9NY64,P24390,P04439,P10321,Q9H0U4,Q86Y82,Q9GZY8,P11717,O60499,O95249,O43760,P49755,O15126,P20645,P61020,Q9BT78,Q96A57,Q9BVK6,O43493,O76024,P51790,O75396,Q9Y3B3 42 +Synaptic vesicle membrane 0.6603497389547283 2.5627188161308454 0.0103856120913157 0.9999219816512084 0.173738072233878 17 P20020,Q86Y82,O60499,O43752,O43760,O76024,O15126,Q15907 8 +Organelle envelope lumen 0.5327071632810432 2.5463336449660012 0.0108861084551155 0.999950665696497 0.1761216832202616 38 Q9NR28,P07437,Q53H12,O95831,P11717,O60313,P78537,Q16891,Q9Y5J9,Q9H4A6,O00584,O14925,Q9BPX6 13 +Cis golgi network 0.6792321649812324 2.5165185320703185 0.0118520667007346 0.9999796435617204 0.1815589065247572 15 P98194,Q8TBA6,O95249,P49755,Q96JB2,P24390 6 +Snare complex 0.6521188755339198 2.5114459810603713 0.0120237686440236 0.9999826089491536 0.1815589065247572 17 O15400,Q9P2W9,O60499,O95249,O95721,O43752,Q12846,Q13190,Q12981 9 +Proton transporting atp synthase complex 0.7429853035304383 2.49503326910902 0.0125945321086289 0.9999896973668432 0.1840426788777066 11 P24539,Q96IX5,P56385,P00846,O75964 5 +Phagocytic vesicle membrane 0.5832011751130812 2.4686333513885232 0.0135630106737241 0.9999957652261748 0.1847848867020739 24 P04439,Q9Y487,P10321,Q9BZG1,P13473,Q12846,P61026,Q04656,P11279,Q15907,O75396,Q93050 12 +Late endosome membrane 0.5305000516776105 2.468084297559373 0.0135838326203001 0.9999958454436184 0.1847848867020739 34 Q14108,P13473,Q8IV08,Q15043,Q9Y3E7,O15118,Q9P253,P11279,P51790,Q9UQN3,O95772 11 +Transporter complex 0.4886553251516803 2.4646372029756964 0.0137152042919643 0.9999963177063383 0.1847848867020739 52 O75381,Q9P0J0,Q9UDW1,O14949,Q8TDW0,O95169,P14927,Q86Y39,Q96CU9,O96000,O75306,P05023,P22695,Q9Y6M9,Q9Y5J9,Q9NX14,Q9BPX6,Q8NE86,Q9Y276,Q4KMQ2,O95168,Q8IYU8 22 +Basolateral plasma membrane 0.5079997755280957 2.464633138348852 0.0137153598583574 0.999996318232512 0.1847848867020739 45 P41440,P20020,Q04656,P35613,P05026,P23634,Q12846,P78310,P05023,P30825,Q15043,Q6P4Q7,P35670,Q14168,Q14118,P57105,P02786,Q9Y6M7,O75955 19 +Mitochondria associated endoplasmic reticulum membrane 0.8046820374254716 2.4639359666909013 0.0137420659377947 0.9999964074565816 0.1847848867020739 8 Q15388,Q96N66,P27824,P51572,O96008 5 +Basal part of cell 0.4880300943357902 2.45849498205875 0.0139520726309354 0.9999970378281317 0.1847848867020739 52 P41440,P20020,Q04656,P35613,P55011,P05026,P08195,P42785,P23634,Q12846,P78310,P05023,P30825,Q15043,Q6P4Q7,P35670,Q14168,Q15758,P54709,Q14118,P57105,P02786,Q9Y6M7,O75955 24 +Endocytic vesicle membrane 0.5119558382185138 2.436991740696823 0.0148100176281282 0.9999986538037012 0.18898416860682 42 P10321,Q9Y487,Q14108,Q9BZG1,Q8WTV0,P13473,Q12846,P61026,P02786,Q04656,P11717,O43493,P11279,Q15907,P20645,Q93050,Q9NY64 17 +Autophagosome 0.5270396481008359 2.4265535098497217 0.0152430022843008 0.9999990960539812 0.1918077787441192 33 Q9UHD9,Q9Y679,P02792,Q96A57,Q96GC9,P13473,Q13501,Q9Y3E7,Q9HD42,Q9NRR5,O95721,Q9Y371,Q9P253,O75787,P11279,Q969Q5,Q9UQN3,Q9Y6I9 18 +Autophagosome membrane 0.6440344842712776 2.3799890945583795 0.0173131504168211 0.9999998656861644 0.2051764591763954 16 P13473,Q96GC9,Q9Y371,O95721,O75787,P11279,Q9Y6I9,Q9UQN3 8 +Specific granule membrane 0.6237856523634425 2.3324995400610957 0.0196744270853252 0.999999984811298 0.2135192232372999 17 P30519,O00264,Q07065 3 +Pigment granule 0.448704201638181 2.3257450301159577 0.0200321567054861 0.9999999890877722 0.2135192232372999 60 O14773,P41440,P07237,Q92820,Q04656,P61019,P35613,P11279,P62820,P08195,Q92542,P55209,P27824,P05023,O00560,P05556,P49755,O43852,Q93050,P61020,P04843,P57088,Q15758,P54709,P02786,O75396,O75955 27 +Synaptic membrane 0.4907690250068996 2.3048562432455557 0.0211746259301544 0.999999996207475 0.2165370349248111 45 Q99720,Q15375,P27824,P20020,Q8NCG7,Q92542,P23634,Q9UQB8,Q14118,O75787,P57105,Q12846,Q14168,Q96A49,P51790,P52292 16 +Postsynaptic membrane 0.5125203968586479 2.293097908569833 0.0218423687759794 0.9999999979563062 0.2198798456781931 32 Q99720,P27824,Q8NCG7,P23634,Q14118,O75787,P57105,P51790,Q14168,Q96A49,P52292 11 +Endoplasmic reticulum tubular network 0.7008775442383864 2.270945780537472 0.0231502603967836 0.9999999993919276 0.2206472547641987 11 Q9NQC3,Q8NHH9,P50402,Q00765,Q9H6H4 5 +Acrosomal vesicle 0.5868187746937727 2.2616001289802363 0.0237221200422925 0.9999999996422784 0.2206808404505665 19 Q9Y487,P09622,P36639,P45880,P35613,P78310 6 +Oxidoreductase complex 0.4390695621085488 2.259206310328169 0.0238705544858228 0.9999999996883144 0.2206808404505665 61 P09622,O95169,P14927,Q86Y39,Q9Y276,P22695,Q9P0J0,Q96CU9,Q9Y6M9,Q9UDW1,P21912,O96000,P13674,O14949,O95168,O43169 16 +Micos complex 0.8590690208667744 2.2544296185611885 0.0241691537328343 0.99999999976377 0.2207586517986337 5 Q16891,Q6UXV4,Q5XKP0,Q9BUR5 4 +Cell surface 0.4405386646928522 2.235224270186246 0.025402628892954 0.999999999924896 0.2255610944145007 77 P41440,Q99623,P11279,O75298,P08195,P35232,Q12907,Q12846,P08183,P10321,Q08722,P06576,P11717,P05556,P00813,O15258,P42892,Q13641,Q5ZPR3,O96005,Q8WTV0,Q8TCT9,O15031,Q14118,P51790,Q4KMQ2,P02786,O75787,O75955 29 +Proton transporting atp synthase complex coupling factor f o 0.7916603676845739 2.216605272637638 0.0266500769589426 0.999999999976465 0.2303919586372253 7 P24539,P00846,O75964 3 +Recycling endosome membrane 0.5534533017610669 2.2145027100147856 0.0267942164904801 0.9999999999794202 0.2303919586372253 23 P04439,P10321,P01889,Q96PE3,P61026,Q86Y82,P02786,Q9H4M9,Q9H223,O15127,P61106,O15126,Q15907,O14828 14 +Mitochondrial envelope 0.6091088790622368 2.1901062922850687 0.0285165290046867 0.9999999999958648 0.2371237247063087 317 Q8N4H5,Q9H9B4,Q16134,Q96A26,Q9H2D1,Q567V2,Q9NS69,Q9NZ45,Q9H9P8,Q9UDW1,Q9Y277,Q9Y2R0,Q69YU5,O14949,P21796,O43169,P18031,O60830,O43615,O75964,Q9NVH1,Q9BQ95,P13073,P14406,P24539,Q8NI60,P35232,P45880,Q96CU9,P09669,Q13505,Q96B49,Q10713,O14925,P00846,Q9H061,P20674,Q9NUQ2,P12235,P22830,O75306,Q7Z7H8,Q15070,Q9Y6M9,Q9UBX3,P00403,Q9UDX5,Q13423,P09601,P57105,Q6PI78,O00264,Q5XKP0,O75027,Q9P0J0,Q99623,Q7KZN9,P23786,P50416,Q9BUR5,Q9BWH2,Q70HW3,Q8NBN7,Q86Y39,Q53H12,P21912,O96000,Q6UXV4,Q9NR28,P22695,O60313,Q16891,Q9H4A6,Q9NZJ7,O43819,Q07820,Q12981,Q8IUX1,Q96E52,Q9Y6C9,Q9NVI7,Q9NQZ5,Q9BXK5,Q9Y276,Q9NPL8,Q9UG56,Q9H300,Q02127,O75880,O95202,Q5T9A4,O43772,O95169,P14927,Q9BQT8,Q9UJS0,O00584,Q96IX5,Q9Y512,P52789,Q9GZY8,O95831,Q96TC7,P30536,P56385,P82933,Q9BPX6,Q15388,Q6P4A7,O75431,Q9Y371,Q9H3K2,Q9HC21,O95168,Q6DKK2,Q6NUK1,Q9Y6N1,Q3ZCQ8,Q8N2A8,O75746,Q9NX63,O95674,Q9P0S9,P06576,Q9Y5J9,Q9NX14,Q8NE86,Q9BUB7,O95140,O96008,Q96I36,Q9Y320 132 +Transport vesicle membrane 0.4739746430146561 2.189946318474308 0.0285281302350857 0.9999999999959094 0.2371237247063087 47 Q9UBV8,P20020,Q15363,Q15907,Q13190,Q12770,Q9NR31,O43752,P49257,P04439,P10321,Q86Y82,O60499,O43760,P49755,O15126,P61020,O76024,O75396,Q9Y3B3 20 +Intrinsic component of synaptic vesicle membrane 0.6805161860916266 2.160383515779534 0.0307429924822193 0.9999999999994827 0.25162227617138 11 P20020,Q86Y82,O60499,O43752,O76024,O15126 6 +Intrinsic component of nuclear inner membrane 0.7741728236427796 2.135255922427994 0.0327401112046903 0.9999999999999202 0.2601977258899074 7 O94901,Q5SNT2,Q9Y2U8,Q9UH99,Q8NC56,Q9BTV4 6 +Postsynaptic specialization membrane 0.6592991306230896 2.120838493344445 0.0339353961152535 0.999999999999974 0.2665111714670667 12 Q99720,P23634,P57105,Q14168,P52292 5 +Dendrite membrane 0.8207627053757899 2.0881935177177526 0.0367803818209884 0.9999999999999982 0.2800254279816428 5 P20020,P23634,Q14168 3 +Side of membrane 0.418080477546935 2.0788479188418028 0.037631330923052 0.9999999999999992 0.2841165484690429 69 P41440,P20020,P11279,P18031,P08183,P04439,P04899,P10321,P27824,P17900,Q9NR28,O43464,P00813,P05556,P51572,Q96A49,P10619,P42892,P01889,O96005,Q9Y5X3,Q8TCT9,Q14118,O75787,Q5ZPR3,P02786,P51790,O75955 28 +Azurophil granule lumen 0.4699791312676549 2.0696372173985904 0.0384863300884792 0.9999999999999996 0.285949431489788 43 P06280,Q13217,Q96CS3,P08236,P17900,Q92820,Q9H7Z7,O43681,Q9BTY2,P07437,O00560,P04066,P16278,P15586,O00584,P10619,P68371 17 +Early endosome membrane 0.4709161449748754 2.060630472236951 0.0393383073362145 1.0 0.2897602150130927 42 O15400,Q8N4V1,Q04656,Q15075,O14964,Q9H4M9,P61106,P20338,Q9UNH7,P04439,P10321,O60749,Q86Y82,Q15043,Q9H223,P61020,P01889,Q92783,Q8IV08,Q9Y5X3,Q96PE3,P51790,O60493 23 +Nuclear outer membrane endoplasmic reticulum membrane network 0.5878933723654863 2.0179295868848968 0.0435985951510955 1.0 0.3036315686324357 301 Q99720,Q8N0U8,Q8N4V1,Q15006,P61026,Q9NZ01,Q9P2W9,Q9UBV2,P18031,Q13190,O75298,Q8TDW0,O95772,Q96CS3,Q5JRA6,Q14108,Q07065,P30519,P51648,P43307,Q96S52,O95197,P24390,Q99735,Q9H0U3,Q9BVC6,Q8NHP6,Q9NQC3,Q9Y5M8,Q9Y282,O75844,Q9BRR6,O95470,Q8IV08,O60725,Q70UQ0,Q16850,P09601,Q9Y6I9,O00264,Q96A33,Q96KC8,Q9BT22,Q15363,Q96PC5,P35613,Q9HD20,Q86YN1,P50402,P16615,Q8NF37,Q10472,Q9BUR5,Q14534,Q8NHH9,Q9BVG9,Q5BJH7,Q8N5M9,Q15904,Q86UE4,Q8TB61,P49755,O95070,P37268,Q12981,Q5H8A4,Q15800,Q15005,O76024,P38435,Q8TCT9,Q53GQ0,Q5BJF2,Q96GC9,Q86XL3,P46977,P51571,Q9NPA0,Q15041,O15269,Q96AG4,O15260,Q12770,Q96N66,Q9H6R6,P16435,P07099,Q15629,P10321,Q9H0U4,P27824,Q9P035,Q969V3,O94905,P51572,O43852,Q9BV10,O75845,Q9NZ08,Q9H6U8,Q9BUN8,Q8TD16,Q9Y3B3,P52292,Q9Y394,Q9UM00,Q9NTJ5,Q06136,Q15392,Q92643,Q9Y3A6,Q6NUQ4,A1L0T0,P04035,O75477,Q96HY6,Q9UNL2,Q99442,Q9H6H4,O95674,Q5VV42,O00560,Q9BU23,Q9UGP8,Q9Y4P3,Q9H3N1,P04843,P57088,Q16799,O75787,Q99640,Q9Y320 132 +Golgi apparatus subcompartment 0.4355319406050131 2.0169927706754582 0.0436962677512366 1.0 0.3036315686324357 90 P0CG08,Q9BZG1,Q8NBN3,Q15363,P61026,Q04656,Q8TBA6,P04062,Q16706,Q96L58,P98194,Q10472,Q9BSR8,O15127,O43752,Q10713,Q4J6C6,Q9NX62,Q12846,Q96JB2,Q11206,P04439,P83436,Q10471,P11717,O60499,O95249,P53367,P51572,Q9H4A6,P35670,P20645,Q96A57,O43493,Q14789,O14828 36 +Microbody membrane 0.521822395318708 2.011427869990674 0.0442802820121179 1.0 0.3036315686324357 24 Q9NR77,O75381,P04035,Q9BY49,P51648,P40855,O43808,Q15067,O00116 9 +Lumenal side of membrane 0.6924591865710559 2.009587563567873 0.0444748585911105 1.0 0.3036315686324357 9 P10321,Q8TCT9,P27824,P10619 4 +Pore complex 0.7112235774719804 2.0091297467650526 0.0445233757089875 1.0 0.3036315686324357 8 P21796,Q9Y277 2 +Tim23 mitochondrial import inner membrane translocase complex 0.8019486454417346 2.005453629668162 0.0449145732802234 1.0 0.3036315686324357 5 O14925,O60830,Q3ZCQ8 3 +Postsynaptic density membrane 0.6909867784709757 2.001970903325747 0.0452878609837137 1.0 0.3036315686324357 9 Q99720,P23634,Q14168,P57105 4 +Integral component of synaptic vesicle membrane 0.7681438664097533 1.987263236434816 0.0468932334241782 1.0 0.3050859439471455 6 P20020,Q86Y82,O60499,O43752,O76024 5 +Sarcolemma 0.4977583696810035 1.9738764889963445 0.0483957887361548 1.0 0.3109686850706117 28 P41440,Q9H9S5,P05023,Q92542,P05556,P35613,P23634,Q14118,P11279,O75955,O75298 11 +Intrinsic component of presynaptic membrane 0.7932759199258843 1.9670747454290876 0.0491745942789421 1.0 0.3110456418811256 5 P20020,P27824,Q92542 3 +Intrinsic component of synaptic membrane 0.6605305784479125 1.9421148812282107 0.0521231943855982 1.0 0.3178501913050525 10 Q15375,P27824,P20020,Q92542,P23634,P51790 6 +Mitochondrial protein containing complex 0.4934880699653881 1.9408755375706217 0.0522733758327293 1.0 0.3178501913050525 159 Q5XKP0,Q8N4H5,Q567V2,Q9NS69,Q9P0J0,Q9UDW1,Q99623,Q3ZCQ8,O14949,P21796,O60830,O75964,P13073,P14406,P24539,Q9BUR5,O95169,P14927,Q86Y39,Q53H12,Q96CU9,P21912,Q13505,O96000,O14925,Q96IX5,P00846,Q9NX63,Q9Y512,P20674,Q6UXV4,Q7Z7H8,P06576,P22695,Q9Y6M9,Q16891,Q9Y5J9,Q9NX14,P56385,P82933,P00403,Q9BPX6,Q15388,P09622,O75431,Q9Y276,O95168 47 +Vacuole 0.5289802817033962 1.908997343614214 0.0562624343447888 1.0 0.3355668583779406 210 O14773,Q9Y487,Q5BJF2,O15400,Q9H7Z7,Q96GC9,Q16625,O15118,P04062,Q9UHG3,P11279,Q9NX40,O15260,O95772,P11117,P06280,Q8NF37,Q14108,Q13510,Q07065,Q9UHD9,Q9BTY2,P50897,P42785,Q92542,Q9UM22,O00584,Q9UIQ6,Q969Q5,Q9NY64,Q8NHP8,O75503,O60749,P17900,P07437,Q15043,P00813,O95721,Q9NZJ7,Q93050,Q15165,P20645,P10619,P42892,P08236,Q9UMR5,P09622,Q8WTV0,Q96A57,P13473,P38571,Q8IV08,P38435,Q8NCG7,Q9Y371,P10253,Q9P253,P04066,P16278,P15586,P54802,Q8NCC3,P51790,Q9Y6I9,P06865,P68371 66 +Presynapse 0.4299030126662307 1.903271484179561 0.0570051297287814 1.0 0.3355668583779406 94 P41440,O15400,P20020,P61026,Q99623,P11279,Q15907,Q9UI14,P50897,Q92542,P23634,O43752,P07196,Q9NY64,P27824,Q9GZY8,O95721,O60499,O43760,Q96A49,Q13641,Q9BT78,Q96A57,Q9P253,O76024,P51790 26 +Mitochondrial proton transporting atp synthase complex coupling factor f o 0.7728114438248982 1.8759308409960815 0.0606647770646742 1.0 0.347862582408828 5 P24539,O75964 2 +Intermediate filament 0.5156925049372324 1.8481997291542571 0.0645734546022065 1.0 0.3589174838625713 20 P20700,P48681,Q03252,P02545,Q16352,P07197,P08670,P07196,O75298 9 +Haus complex 0.831305336888115 1.8196137827257497 0.0688178412616302 1.0 0.3733470909163893 4 Q9H6D7,O94927 2 +Nadh dehydrogenase complex 0.4916241790177832 1.810384610377636 0.0702361641692366 1.0 0.3781809675743686 25 O95169,Q86Y39,Q9P0J0,Q96CU9,Q9Y6M9,O96000,O95168 7 +Dendritic spine membrane 0.8146860350782988 1.7495366609269611 0.0801982974533865 1.0 0.4160144878912367 4 P20020,P23634 2 +Caveola 0.5524439564733643 1.7305403443980547 0.0835337795754487 1.0 0.4180204622037844 15 P05026,P41440,P27361,Q8WTV0,P23634,P09601,O75955 7 +Recycling endosome 0.4375945680796119 1.7288861015716797 0.0838294820023082 1.0 0.4180204622037844 41 Q8N668,O14773,O15400,P61026,Q15907,Q9UNK0,Q9H4M9,O15127,P61106,P04439,P10321,Q86Y82,Q9H223,P05556,O15126,P01889,Q96A57,Q96PE3,P51790,P02786,O14828 21 +Er to golgi transport vesicle membrane 0.4844488223245476 1.7213248885483323 0.0851918856122626 1.0 0.419477436764728 24 P04439,P10321,Q9UBV8,Q15363,Q9NR31,Q9Y3B3,P49755,O75396,P49257,Q13190,Q12770 11 +Presynaptic active zone membrane 0.7311755223546076 1.6880791793380214 0.0913960306164844 1.0 0.4300063550366067 5 P20020,P23634,P27824 3 +Apical part of cell 0.394626065313432 1.686508326310823 0.0916979327227265 1.0 0.4300063550366067 59 P41440,P20020,Q16625,Q04656,P55011,P05026,P08195,P41208,P23634,Q8TAD4,P08183,Q15154,Q86UE4,P05023,P30825,Q15043,P36543,P54709,O75787,P51790,Q9Y6M7,O75955 22 +Extrinsic component of organelle membrane 0.609197405238097 1.660857520802557 0.0967420654720863 1.0 0.4404437754658803 10 O14656,Q8NI60,P49748,Q15006,Q9Y5X3,P51149 6 +Platelet dense granule lumen 0.9644002565747274 1.650661444146203 0.0988077248027767 1.0 0.4445137752180762 2 Q08380 1 +Derlin 1 retrotranslocation complex 0.7900650576595092 1.6450483460838057 0.0999598414668614 1.0 0.4445137752180762 4 Q9UBV2,Q8TCT9 2 +Presynaptic active zone 0.5392348855638401 1.6446456149969009 0.1000429142330885 1.0 0.4445137752180762 15 P41440,P27824,P20020,P23634,Q99623,Q12846,O75955 7 +Phagocytic vesicle 0.4240448222244948 1.6424987578449957 0.1004866833720643 1.0 0.4445137752180762 44 P04439,Q9Y487,P10321,Q9BZG1,P13473,Q12846,P61026,Q86Y82,Q04656,O43752,P11279,P51790,Q15907,P08670,O75396,Q93050 16 +Organelle subcompartment 0.5765100576349853 1.6260843226266026 0.1039317185989978 1.0 0.4460804025301142 369 Q99720,Q8N0U8,Q8N4V1,Q8NBN3,Q15006,P61026,Q9P2W9,Q9UBV2,Q9NZ01,P18031,Q13190,O75298,O95772,Q8TDW0,Q96CS3,Q14108,Q5JRA6,Q07065,P30519,P51648,P43307,O15127,Q96S52,Q10713,Q9NX62,Q4J6C6,Q12846,O95197,P24390,Q8NHP6,Q99735,Q9H0U3,Q9BVC6,Q9NUQ2,Q9NQC3,P11717,Q9Y5M8,O60499,O95249,Q9Y282,O75844,Q9BRR6,Q96A57,Q9NRR5,O95470,Q8IV08,O60725,Q70UQ0,Q9BVK6,Q16850,P09601,Q14789,Q96HE7,Q9Y6I9,O75396,O00264,Q96A33,Q96KC8,O75915,P0CG08,Q9Y679,Q9BT22,Q15363,Q96PC5,Q15738,P61019,P35613,Q16706,Q9HD20,Q86YN1,P50402,P16615,Q8NF37,Q10472,Q9BUR5,Q969X5,Q14534,Q8NHH9,Q9BVG9,Q5J8M3,Q12907,Q5BJH7,Q7Z7H5,Q8N5M9,Q96JB2,P49257,Q11206,Q15904,P00387,Q6NUM9,O43464,P04439,P83436,Q10471,Q14739,Q86UE4,Q8TB61,Q6NUQ1,P53367,P49755,Q9H4A6,O14880,O95070,O15126,P37268,Q12981,P01889,O94888,Q5H8A4,Q15800,Q15005,O43493,O76024,P38435,Q8TCT9,Q53GQ0,Q5BJF2,Q96GC9,Q86XL3,P46977,P51571,Q8TBA6,P04062,Q9NPA0,Q15041,O15269,Q96AG4,Q96L58,O15260,Q12770,Q96N66,P98194,Q9H6R6,P16435,P07099,Q00765,Q15629,P10321,Q9H0U4,P27824,Q9P035,Q969V3,O94905,P51572,O43852,P35670,Q9BV10,P20645,O75845,Q9NZ08,Q9H6U8,Q9BUN8,Q9Y3B3,P52292,Q9Y394,Q9BZG1,Q9UM00,Q04656,Q9NTJ5,Q06136,Q15392,Q92643,Q9Y3A6,Q6NUQ4,A1L0T0,Q9BSR8,P04035,O75477,Q96HY6,Q9UNL2,Q99442,O43752,Q9H6H4,O95674,Q5VV42,O00560,Q9BU23,Q9UGP8,Q9Y4P3,Q9H3N1,P04843,P57088,Q16799,O75787,Q99640,Q9Y320,O14828 187 +Vacuolar proton transporting v type atpase v0 domain 0.7825544121113148 1.6130274329118288 0.1067385479378915 1.0 0.4471748791377021 4 Q93050,Q9Y487 2 +Proton transporting v type atpase v0 domain 0.7825544121113148 1.6130274329118288 0.1067385479378915 1.0 0.4471748791377021 4 Q93050,Q9Y487 2 +Secondary lysosome 0.7814505776636529 1.6083159573011887 0.1077659975422133 1.0 0.4471748791377021 4 P02792,P13473,P11279 3 +Autolysosome 0.7814505776636529 1.6083159573011887 0.1077659975422133 1.0 0.4471748791377021 4 P02792,P13473,P11279 3 +Presynaptic membrane 0.5243623921087133 1.6076045297602513 0.1079218195189557 1.0 0.4471748791377021 16 P27824,P20020,Q92542,P23634,Q96A49 5 +Lumenal side of endoplasmic reticulum membrane 0.664381157281293 1.607188163263183 0.1080130978139366 1.0 0.4471748791377021 7 P10321,P04439,P27824,P51572,Q8TCT9 5 +Triglyceride rich plasma lipoprotein particle 0.9474021808851898 1.580173062034259 0.1140672390264481 1.0 0.4582213880163246 2 Q9UHG3 1 +Golgi medial cisterna 0.7747111681642953 1.579521466853597 0.1142164965954957 1.0 0.4582213880163246 4 O95249,Q16706,Q96L58 3 +Sarcoplasmic reticulum membrane 0.6097318642396499 1.571903332634332 0.1159729715544617 1.0 0.4587520163522571 9 O75298 1 +Gaba ergic synapse 0.6089420342770518 1.5676339951171905 0.1169665737057079 1.0 0.4587520163522571 9 P41440,P20020,P23634,Q99623,Q14118 5 +Trans golgi network membrane 0.4484184777324535 1.5621790694528983 0.1182458099408167 1.0 0.4603801200622007 28 P83436,Q04656,P11717,O15127,O43752,O60499,P53367,P35670,Q9NX62,P20645,Q96JB2,O14828 12 +Plasma membrane raft 0.4735768894877107 1.5558750932408043 0.1197377970697626 1.0 0.4603801200622007 21 P05026,P41440,P27361,Q8WTV0,P23634,P09601,Q14118,O75955 8 +Proteasome core complex beta subunit complex 0.6538582434633117 1.5550993263665784 0.1199224153804408 1.0 0.4603801200622007 7 P28074 1 +Platelet dense granule 0.9268527430221324 1.5502505979075036 0.1210813796758705 1.0 0.4628680590140873 3 Q92520,Q08380 2 +Endoplasmic reticulum tubular network membrane 0.9232502960397252 1.536182564536353 0.1244936109774608 1.0 0.4699633814399145 3 Q9NQC3 1 +Golgi lumen 0.761874187970491 1.5245456824807484 0.1273724542901755 1.0 0.4768326813474767 4 Q14118,Q9NX62 2 +Gamma secretase complex 0.9320076972418212 1.5162815753187946 0.1294481684698269 1.0 0.4768326813474767 2 Q92542 1 +Intrinsic component of presynaptic active zone membrane 0.7572123147771761 1.5045419674421052 0.1324418758893784 1.0 0.4818969460071358 4 P20020,P27824 2 +Integral component of presynaptic active zone membrane 0.7572123147771761 1.5045419674421052 0.1324418758893784 1.0 0.4818969460071358 4 P20020,P27824 2 +Proton transporting v type atpase complex 0.5803390864833293 1.499312872874112 0.1337924843881175 1.0 0.4848639634225379 10 Q93050,Q9Y487 2 +Intrinsic component of vacuolar membrane 0.9265554842848012 1.4936494761650254 0.1352672604981031 1.0 0.4872781665798404 2 O15118 1 +Zymogen granule 0.7518896126722155 1.481679564050338 0.1384255772268843 1.0 0.4918179332061066 4 Q15363 1 +Brush border membrane 0.5881237393609334 1.4545559785435516 0.1457922255493389 1.0 0.5105386108750176 9 P41440,P40855,Q04656 3 +Rough endoplasmic reticulum 0.4142498642330746 1.4285275990318136 0.1531400566025458 1.0 0.5157802649885 33 Q5BJF2,P27824,Q5VV42,Q07065,P04843,P51571,Q99442,Q9Y5M8,Q96A33,Q15041,Q8TCT9,Q9UGP8 12 +Membrane protein complex 0.5281723410596372 1.4255809014088174 0.1539893523539124 1.0 0.5167198267875728 281 P41440,Q8N4H5,Q9UBV8,Q8N4V1,Q15006,O94901,Q9NS69,Q9P2W9,Q9UBV2,Q9UDW1,Q9Y277,O14949,P21796,Q13190,O60830,O75964,Q9NVH1,Q8TDW0,P13073,P14406,Q96CS3,P24539,P35232,P45880,Q9Y3E7,P09669,Q96CU9,Q96S52,Q13505,Q12846,O14925,P00846,Q9H0U3,P20674,P12235,O75306,Q9Y4W6,P11717,P05556,Q9Y6M9,Q9Y5M8,O95249,O60499,Q9H9H4,Q93050,P00403,P12236,Q4KMQ2,P02786,O75396,O75955,Q8IYU8,Q9Y487,Q5XKP0,O15400,Q9Y679,Q9P0J0,Q99623,P05026,O75947,Q9BUR5,P08195,Q86Y39,Q53H12,Q92542,P21912,Q5J8M3,O96000,Q15904,O43464,P04439,P04899,O60749,Q6UXV4,Q9NR28,P05023,Q86Y82,Q9HD42,P22695,O95721,Q16891,P49755,P05141,Q12981,P01889,O94888,P36543,Q9Y5X3,Q9Y276,O00483,Q15005,P62993,P54709,P25054,Q8TCT9,Q53GQ0,P46977,P51571,Q9NPA0,Q15041,O15269,O95169,P14927,Q96IX5,Q9Y512,P10321,P56385,Q9BPX6,Q15388,O75431,Q9P253,Q9BUN8,Q14118,O95168,Q9Y3B3,Q92643,Q3ZCQ8,Q9NR31,O43752,Q9NX63,Q9UQN3,O00459,P06576,O00560,Q9UH99,Q9NX14,Q9UGP8,Q8NE86,P04843,O75787,O96008 131 +Intermediate filament cytoskeleton 0.4120524950225664 1.4026739979934562 0.160714074492718 1.0 0.5267686029693697 32 P20700,Q3SXM5,P48681,Q03252,Q16352,P07197,P08670,P07196,O75298 9 +Oligosaccharyltransferase complex 0.5869484494056956 1.367986624602739 0.1713162628492468 1.0 0.5427179307251959 8 P46977,P04843 2 +Dna replication preinitiation complex 0.5415047312963294 1.3679697203675294 0.1713215542907351 1.0 0.5427179307251959 11 Q14566,Q9Y248 2 +T tubule 0.5846374412347126 1.3557318283064592 0.1751845086148669 1.0 0.5436110186056039 8 P05023,O75298 2 +Endocytic vesicle 0.375991082998744 1.343344396536548 0.1791604825425239 1.0 0.5436110186056039 87 Q9Y487,Q9BZG1,O15400,P61026,Q16625,Q04656,P11279,Q15907,Q14108,Q9H4M9,O43752,Q12846,Q969Q5,Q9NY64,P04439,P10321,Q86Y82,P11717,Q9H223,Q93050,P20645,P61020,Q8WTV0,P13473,O43493,P51790,P02786,P08670,O75396 29 +Protein lipid complex 0.8735833023495396 1.3418975874113992 0.1796292041292666 1.0 0.5436110186056039 3 Q9UHG3 1 +Emc complex 0.6106350181286884 1.3388986761494168 0.1806036607067183 1.0 0.5436110186056039 7 Q15006,Q9NPA0,Q8N4V1 3 +Early endosome 0.3814456249447015 1.3234328952325332 0.185691458418254 1.0 0.5534094122596651 94 Q8N668,P41440,Q8N4V1,O15400,Q04656,P18031,P31751,Q9UNK0,Q13510,P62820,P35232,Q92542,Q9H4M9,O43752,P61106,Q9UIQ6,P20338,P04439,O60749,P10321,Q86Y82,Q9HD42,Q15043,P11717,Q9H223,P61020,P01889,Q92783,P27361,Q96A57,Q92544,Q8IV08,Q96PE3,Q9Y5X3,Q9P253,Q5VW38,Q9BUN8,P51790,P02786,O75955 40 +Rough endoplasmic reticulum membrane 0.5008271575786428 1.3139071824539594 0.1888774413552953 1.0 0.5610588913701561 14 Q5BJF2,Q96A33,Q9Y5M8,P51571 4 +Neurofilament 0.7084963194925464 1.294606665779907 0.1954559517300409 1.0 0.5730844409948772 4 P07196,Q16352 2 +Anchored component of synaptic vesicle membrane 0.6442674908607566 1.287467837862854 0.1979312727088604 1.0 0.5784701066910567 5 P61020,Q15286,P51149 3 +Prefoldin complex 0.6419778947232611 1.276807930595658 0.2016700649847322 1.0 0.5837478558344008 5 O15212,Q9UHV9 2 +Neuron projection membrane 0.518108589938173 1.2290543207246756 0.2190514401466154 1.0 0.6170003626434339 11 P20020,Q9HBM0,P23634,O75787,Q12846,Q14168 6 +Intrinsic component of postsynaptic membrane 0.5848973055933511 1.208777086960003 0.2267484966975681 1.0 0.6301660675091925 7 P23634,P27824,P51790 3 +Copi coated vesicle 0.5043325974819992 1.2034501687372343 0.2288021637879564 1.0 0.6339289308620445 12 Q15363,P49755,P24390 3 +Compact myelin 0.8543938422065425 1.195162547681321 0.2320235281793141 1.0 0.6373891793242566 2 Q9NR77 1 +Trans golgi network 0.3420343629133063 1.1946077854942283 0.2322403059872415 1.0 0.6373891793242566 66 P98194,Q9BSR8,Q96A57,P61026,Q04656,P04062,O15127,O43752,O60499,Q9NX62,P35670,Q4J6C6,Q12846,Q9H4A6,P20645,O43493,Q96JB2,O14828 18 +Anaphase promoting complex 0.5120668897669115 1.1930108043562808 0.2328651416736522 1.0 0.6373891793242566 11 Q9UJX6,O60566,Q9UJX4,P30260,Q16763,Q9UJX3,Q9UJX5 7 +Coated vesicle 0.3688546926603208 1.1807852359492703 0.237688050646504 1.0 0.6416358968514289 93 Q9UBV8,Q15363,Q04656,Q9Y3A6,Q13190,Q12770,Q14108,Q969X5,Q9NR31,O43752,Q12907,Q5BJH7,Q7Z7H5,P49257,Q9NY64,P24390,P04439,P10321,P11717,P51572,Q9Y282,P49755,O15126,O95070,P20645,P42892,Q9BVK6,Q9P253,Q5VW38,O43493,P02786,O75396,Q9Y3B3 33 +Nuclear envelope lumen 0.6815832928482366 1.178327945593157 0.2386658909921981 1.0 0.6416358968514289 4 P07437 1 +Mitochondrial crista 0.8283606031440527 1.1653086515728572 0.2438940783521879 1.0 0.6497162001731398 3 Q9BUB7,O60313 2 +Retromer complex 0.5317785347680055 1.1441899679161964 0.2525448626697031 1.0 0.6644776640320657 9 O60749 1 +Plasma membrane signaling receptor complex 0.5421360328100396 1.1290166652256652 0.2588908035630952 1.0 0.6682480570602971 8 P02786,O00560,Q9NR28,P05556 4 +Zymogen granule membrane 0.8164292076548162 1.1189482529799828 0.2631622157608078 1.0 0.6691982398541715 3 Q15363 1 +Platelet alpha granule lumen 0.5069355624813916 1.0799408035557918 0.2801685416110187 1.0 0.6922223695168582 10 Q8NBX0,Q9Y6I9 2 +Endosome membrane 0.3872683918228031 1.0454547299066108 0.2958128530189543 1.0 0.6943172145988927 124 Q8N668,Q9Y487,Q8N4V1,O15400,P61026,O14828,O15118,Q04656,P11279,Q15907,Q9UBB6,O95772,Q9UNK0,Q14108,O60831,Q9Y3E7,Q92542,Q9H4M9,O15127,P61106,P20338,Q9UNH7,Q9UQN3,Q15904,P04439,O60749,P10321,Q99805,Q86Y82,Q9HD42,Q15043,P11717,P05556,Q9H223,Q9UH99,Q9H9H4,O15126,Q93050,P42892,Q9BXB4,P61020,P01889,Q92783,P13473,Q8IV08,Q96PE3,Q9Y5X3,Q9P253,O75787,P51790,P02786,Q13546,Q96RL7 53 +Uniplex complex 0.7959576515880629 1.0397900094693069 0.2984374716577394 1.0 0.6986675693072658 3 Q8NE86,Q9BPX6 2 +Dynactin complex 0.5687116368379055 1.035879441788044 0.3002583896915656 1.0 0.6991598373306657 6 O75935 1 +Er ubiquitin ligase complex 0.7933910811677671 1.0299076095849884 0.3030533782444213 1.0 0.6991598373306657 3 Q9UBV2,Q9BUN8 2 +Hrd1p ubiquitin ligase erad l complex 0.7933910811677671 1.0299076095849884 0.3030533782444213 1.0 0.6991598373306657 3 Q9UBV2,Q9BUN8 2 +External encapsulating structure 0.3707581070312249 1.026456557262168 0.3046764308215326 1.0 0.7001529818980374 35 Q92896,Q32P28,Q08380,Q14118,Q9NZJ7,P84157,Q53GQ0 7 +Lamin filament 0.7905036894449757 1.0188026416291247 0.3082966713740109 1.0 0.7035687261079444 3 P20700,P02545 2 +Platelet alpha granule 0.4530269890544811 1.001248173902446 0.3167068417512233 1.0 0.7155521162758313 14 Q8NBX0,Q9Y6I9 2 +Neuromuscular junction 0.4164528046003504 0.9664849679069972 0.3338015652417287 1.0 0.7412358286985448 18 Q15375,O43760,P57105,Q14168,P07196 5 +Dopaminergic synapse 0.7721992622094647 0.9487555882268174 0.3427449345174262 1.0 0.7537060938659907 3 P41440 1 +Clathrin coated endocytic vesicle membrane 0.4323299057828699 0.9284583190623442 0.3531698790865916 1.0 0.7631201325280812 15 O43493,Q14108,Q9NY64 3 +Mhc protein complex 0.7641963426371582 0.9183484135225084 0.3584364887148501 1.0 0.7648941514370637 3 P10321,P04439 2 +Mhc class i protein complex 0.7641963426371582 0.9183484135225084 0.3584364887148501 1.0 0.7648941514370637 3 P10321,P04439 2 +Envelope 0.5329291868605661 0.9137490761053744 0.3608487102156994 1.0 0.7648941514370637 487 Q99720,Q8NFH4,Q8N4H5,Q9H9B4,Q16134,Q96A26,Q9H2D1,Q567V2,O94901,Q9NS69,Q9NZ45,Q03252,Q9H9P8,Q9UDW1,Q9Y277,Q9Y2R0,Q69YU5,O14949,P21796,O43169,P18031,O60830,Q14728,O75964,O43615,Q9NVH1,P13073,P14406,Q9BQ95,P24539,P80303,Q8NI60,P35232,P45880,Q9Y3E7,Q96CU9,P09669,Q7Z3B4,Q13505,Q96B49,Q10713,P02545,O14925,Q8N1F7,P00846,Q99735,Q9H061,P20674,Q9BVC6,Q9NUQ2,P22830,P12235,Q9NQC3,O75306,Q15154,Q9Y4W6,Q7Z7H8,Q7Z569,Q15070,Q5JTV8,Q9Y6M9,Q9UBX3,O75844,P00403,Q9UDX5,Q13423,P09601,P57105,Q6PI78,O00264,Q96KC8,Q5XKP0,O75027,P36639,O15118,Q9P0J0,Q99623,Q9H1E5,P42167,Q7KZN9,P23786,P50402,P50416,Q9BUR5,Q9BWH2,Q70HW3,Q8NBN7,Q86Y39,Q53H12,P21912,O96000,Q6UXV4,Q9NR28,Q86UE4,P07437,P22695,O60313,Q16891,Q9H4A6,Q9NZJ7,O43819,Q07820,Q12981,Q8IUX1,Q8IXM6,Q96E52,Q9Y6C9,Q9NVI7,Q9NQZ5,Q9BXK5,Q9Y276,Q9NPL8,Q5BJF2,Q9UG56,Q9H300,Q02127,O75880,Q96AG4,O95202,Q5T9A4,O43772,O95169,P14927,Q9BQT8,P41208,Q5SNT2,Q9Y2U8,Q9UJS0,O00584,Q96IX5,Q9Y512,Q9P035,P52789,Q9GZY8,O95831,O14657,Q96TC7,P30536,Q9BTX1,Q96C57,P56385,P82933,Q9BPX6,Q15388,Q6P4A7,O75431,Q9Y371,Q9H3K2,Q9HC21,Q8TD16,O95168,Q6DKK2,Q6NUK1,Q9Y6N1,Q3ZCQ8,Q8N2A8,Q9C0E2,O75746,Q8N2G8,Q8NC56,Q9NX63,Q9UQN3,O95674,Q8NFH5,Q9P0S9,P06576,O00560,Q9Y5J9,Q9UH99,Q9NX14,Q9BTV4,Q8NE86,Q6ZRP7,P20700,P57088,Q9BUB7,O95140,O96008,Q96I36,Q9Y320 180 +Coated vesicle membrane 0.3310554287551192 0.9117681075884624 0.3618908023620735 1.0 0.7648941514370637 58 P04439,P10321,Q14108,Q9UBV8,Q15363,P02786,Q9NR31,P11717,O43493,Q9Y3B3,P49755,O75396,P24390,P20645,P49257,Q13190,Q9NY64,Q12770 18 +Clathrin coated vesicle 0.3449049340733375 0.9112095388653731 0.3621849789917222 1.0 0.7648941514370637 50 Q14108,Q04656,Q9P253,Q5VW38,P51572,O43493,P42892,P49755,P20645,Q9NY64 10 +Cation transporting atpase complex 0.7587423804940618 0.8977130072691674 0.3693385730990193 1.0 0.7670011617286295 3 P05026,P05023 2 +Atpase dependent transmembrane transport complex 0.7587423804940618 0.8977130072691674 0.3693385730990193 1.0 0.7670011617286295 3 P05026,P05023 2 +Sodium potassium exchanging atpase complex 0.7587423804940618 0.8977130072691674 0.3693385730990193 1.0 0.7670011617286295 3 P05026,P05023 2 +Blood microparticle 0.41402429569045 0.8950327524114703 0.3707695799739312 1.0 0.7670011617286295 17 P04062,P38435,O00560,Q08380 4 +Platelet dense tubular network membrane 0.7799871712636557 0.894972317675483 0.3708018861337083 1.0 0.7670011617286295 2 P16615 1 +Platelet dense tubular network 0.7799871712636557 0.894972317675483 0.3708018861337083 1.0 0.7670011617286295 2 P16615 1 +Cd40 receptor complex 0.7745349583066309 0.8735705593569315 0.3823521649902839 1.0 0.7772086797722423 2 Q9NR28 1 +Specific granule 0.3544793200964502 0.8727380927940013 0.3828058496879905 1.0 0.7772086797722423 36 Q92820,Q07065,P30519,Q12846,Q08722,P51790,Q8N2G8,Q12905,O00264,Q8NHP6 10 +Paranode region of axon 0.7703656189865284 0.8572784017516755 0.3912910420129489 1.0 0.7772086797722423 2 Q8IXJ6 1 +Cell body membrane 0.7471928136028122 0.8542718420710468 0.3929543850895267 1.0 0.7772086797722423 3 P20020,P23634 2 +Photoreceptor inner segment 0.5139489387313009 0.8484929293447238 0.3961635085561563 1.0 0.7772086797722423 7 P35613 1 +Nuclear outer membrane 0.4466418769806824 0.8477053428924816 0.3966020900814295 1.0 0.7772086797722423 12 Q99720 1 +Gpi anchor transamidase complex 0.7404555662495942 0.8291080107803146 0.4070432911834574 1.0 0.7858987060710297 3 Q96S52,Q92643 2 +Mcm complex 0.5255185569075023 0.8265316911399233 0.4085025484606701 1.0 0.7858987060710297 6 Q14566 1 +Copi coated vesicle membrane 0.4469786575538867 0.803291182984764 0.42180645290675 1.0 0.7919219831244096 11 Q15363,P24390 2 +Juxtaparanode region of axon 0.5881828686295483 0.7803247914360983 0.4351997238821754 1.0 0.7981598174843136 4 Q14168,Q8IXJ6 2 +Ciliary membrane 0.5155233546802116 0.7785844904477105 0.436224518181932 1.0 0.7984230575208694 6 O95721 1 +Endoplasmic reticulum plasma membrane contact site 0.7443874278383705 0.7573935877057775 0.4488140966236664 1.0 0.8092934206947344 2 Q9NTJ5 1 +Endoplasmic reticulum 0.5205333182737886 0.7429229713005527 0.4575283172734949 1.0 0.8123625230974321 472 Q99720,Q8N0U8,Q9UBV8,Q8N4V1,Q15006,P61026,Q9P2W9,Q9UBV2,Q9NZ01,Q9UQB8,P18031,Q13190,O75298,O95772,Q8TDW0,Q96CS3,Q14108,Q5JRA6,P80303,Q13510,Q07065,Q02818,P30519,P51648,P43307,Q96S52,O95197,P24390,Q8NHP6,O75503,Q99735,Q9H0U3,Q9UMX5,Q9BVC6,Q9NUQ2,O75718,Q9NQC3,Q9BRK5,Q9H6V9,Q9Y5M8,O60506,O15258,Q9Y282,Q14257,O75844,P10619,Q9BRR6,Q96A57,O95470,Q8IV08,O60725,Q70UQ0,Q16850,P09601,P84157,Q9Y6I9,O00264,Q96A33,Q96KC8,Q9BT22,Q15363,Q96PC5,O15118,P48723,P35613,Q9HD20,Q86YN1,P50402,P16615,Q8NF37,Q10472,Q9BUR5,Q14534,Q8NHH9,Q92542,Q9BVG9,O95433,Q5BJH7,Q8N5M9,Q15904,Q86UE4,Q8TB61,P05023,P49755,O95070,P37268,Q12981,Q13641,Q32P28,Q5H8A4,Q15800,Q15005,O43493,O76024,P38435,Q8TCT9,Q53GQ0,Q5BJF2,Q96GC9,Q86XL3,P46977,P51571,P04062,Q9NPA0,Q15041,O15269,Q96AG4,O15260,Q12770,Q01105,Q96N66,P98194,O95169,Q9H6R6,Q9BTY2,P16435,Q92791,P07099,Q00765,O00584,Q15629,P10321,Q9H0U4,P27824,Q9P035,P52789,Q969V3,O94905,O14657,P51572,P30536,O43852,Q9BV10,O75845,Q9NZ08,P55327,Q9H6U8,Q9BUN8,Q14118,Q9Y3B3,P52292,Q9Y394,Q8IY95,Q9NWM8,Q8TED1,Q9UM00,Q04656,Q9NTJ5,Q06136,Q15392,Q92643,Q9Y3E0,Q9Y3A6,Q6NUQ4,A1L0T0,Q9BSR8,P04035,O75477,Q96HY6,Q9NR31,Q9UNL2,Q99442,P13674,Q8N2G8,Q8NC56,Q9H6H4,Q13217,O95674,O60476,Q5VV42,O00560,Q9BTV4,Q9BU23,Q9UGP8,Q9Y4P3,Q9H3N1,O43681,P04843,P57088,Q16799,O75787,Q99640,Q9Y320 183 +Intrinsic component of peroxisomal membrane 0.7398973701090421 0.7404471188885455 0.4590287370575676 1.0 0.8123625230974321 2 O43808 1 +Receptor complex 0.3902881075451982 0.7255051927173236 0.4681421603949278 1.0 0.8123625230974321 17 O43464,Q15375,Q9NR28,O00560,P05556,O15031,P02786 7 +Postsynaptic recycling endosome 0.7354073123797285 0.7236046317335859 0.4693084970382286 1.0 0.8123625230974321 2 Q86Y82 1 +Caspase complex 0.5713761321777473 0.7110561941225919 0.4770494141187518 1.0 0.8124187390819344 4 Q96S52,Q92643 2 +Myelin sheath 0.4126603163589758 0.6851796451935744 0.4932305666657566 1.0 0.8221939528917116 13 Q9NR77,P04350,Q12846,Q8IXJ6 4 +Ficolin 1 rich granule membrane 0.3695456914952003 0.671555256896336 0.5018668706944163 1.0 0.8268988355053806 19 P13473,P42785,P11279,Q93050,Q5T9A4 5 +Apicolateral plasma membrane 0.489709997647101 0.6563067864456211 0.5116267518993012 1.0 0.8334926131770993 6 Q16625 1 +Sec61 translocon complex 0.5569045376627934 0.6524140944147745 0.5141340743984855 1.0 0.8334926131770993 4 P51571 1 +Translocon complex 0.5569045376627934 0.6524140944147745 0.5141340743984855 1.0 0.8334926131770993 4 P51571 1 +Extrinsic component of mitochondrial inner membrane 0.6913699069618287 0.6507884265660787 0.5151830721624455 1.0 0.8334926131770993 3 Q8NI60,P49748 2 +Golgi associated vesicle 0.343796139708707 0.6473149907508734 0.5174281014094557 1.0 0.8337539985266971 28 Q15363,O43493,P49755,Q9Y3B3,P24390 5 +Bloc complex 0.6900866217516902 0.6462686150955336 0.5181054096804971 1.0 0.8337539985266971 3 Q86YV9,P78537 2 +Glial cell projection 0.6890821695774485 0.6427367421015137 0.5203949356949964 1.0 0.8359535669143028 3 Q8IXJ6 1 +Extrinsic component of endoplasmic reticulum membrane 0.7126363053239315 0.6399450615430539 0.522208316852026 1.0 0.837381831978647 2 Q15006 1 +Nuclear membrane 0.3365409328885522 0.6347433010119561 0.525595847749373 1.0 0.8413248022277949 105 Q99720,Q5BJF2,O94901,P36639,Q03252,Q9H1E5,Q14728,P50402,Q7Z3B4,Q5SNT2,Q9Y2U8,P02545,Q8NC56,Q8N1F7,Q9BVC6,Q9P035,Q15154,Q86UE4,Q8NFH5,Q7Z569,Q5JTV8,O00560,O14657,Q9UH99,Q9BTX1,Q9NRG9,O75844,Q9BTV4,Q8IXM6,P62995,Q6ZRP7,P20700,Q96KC8 33 +Histone pre mrna 3 end processing complex 0.7078255291853732 0.6226805750716549 0.5334944501125842 1.0 0.8446080425359557 2 O60506 1 +Clathrin coated endocytic vesicle 0.3555600034271395 0.6185919717114754 0.536185192032395 1.0 0.8446080425359557 20 O43493,Q14108,Q9NY64 3 +Nuclear pore nuclear basket 0.4458100719084543 0.6174023815731634 0.5369693515460381 1.0 0.8446080425359557 8 P41208 1 +Postsynaptic endosome 0.6740455566249504 0.5905121292300541 0.5548473564331076 1.0 0.8534663920685831 3 P20338,Q86Y82 2 +Mitochondrial large ribosomal subunit 0.324436752225762 0.5764508211170731 0.5643105017884129 1.0 0.8598433079455081 33 Q567V2 1 +Chitosome 0.6927517639512786 0.5696203051182758 0.5689352534882912 1.0 0.8634092791631354 2 Q04656 1 +Tertiary granule 0.3206142785124344 0.5608373574694351 0.5749084171797203 1.0 0.868081132757198 41 Q13510,O15400,P13473,Q08722,P09960,P10253,P42785,O75787,P11279,Q93050,Q5T9A4 11 +Bloc 1 complex 0.6898652982681222 0.5596492507360257 0.575718704309391 1.0 0.868081132757198 2 P78537 1 +Borc complex 0.6898652982681222 0.5596492507360257 0.575718704309391 1.0 0.868081132757198 2 P78537 1 +Paraspeckles 0.4679954115928139 0.5558753929976492 0.5782960410269631 1.0 0.8703259354990508 6 P23246,Q8WXF1 2 +Sarcoplasm 0.3511135199570502 0.5343052026150239 0.5931303933106573 1.0 0.8852984124208493 19 P16615,O75298,P52789 3 +Cytoplasmic ubiquitin ligase complex 0.4492367965111522 0.5280822899612158 0.5974422222437312 1.0 0.888805670530083 7 Q9UBV2 1 +Early phagosome 0.6738293778062825 0.5054559758580452 0.6132386119471878 1.0 0.8933446458856142 2 O60493 1 +Mitotic spindle microtubule 0.442421389327725 0.4955680963098702 0.6201991666094158 1.0 0.8933446458856142 7 Q9H6D7,O94927 2 +Collagen containing extracellular matrix 0.3185292138590962 0.4941504659715697 0.6211999193244337 1.0 0.8933446458856142 31 Q32P28,P84157,Q08380,Q9NZJ7 4 +Schaffer collateral ca1 synapse 0.3659924018764141 0.4844746518881474 0.6280490495418158 1.0 0.8977896760604106 15 Q15375,Q9BVA1,Q9UQB8,Q16352,P07196 5 +Microtubule organizing center attachment site 0.5135111682658569 0.4840172425203718 0.6283736322342084 1.0 0.8977896760604106 4 Q9UH99 1 +Microbody 0.3027212950569252 0.4730742278569513 0.6361602229285077 1.0 0.9043922753346804 52 Q13011,Q9NR77,O75381,P04035,Q9BY49,P51648,Q9GZY8,O00116,P08670,Q15067 10 +Proteasome core complex 0.3702161910003845 0.4651675431689577 0.6418114798132524 1.0 0.9046865690864088 14 P28074 1 +Cell pole 0.635479411172611 0.4629987225813377 0.6433652827417344 1.0 0.9046865690864088 3 P08195 1 +Nucleotide activated protein kinase complex 0.5077021822849893 0.4625255157971997 0.6437045087985029 1.0 0.9046865690864088 4 P13861,P54619,P10644 3 +Rpap3 r2tp prefoldin like complex 0.4328542403196943 0.4505210630450849 0.6523347700840731 1.0 0.9083583402335952 7 O15212,Q9NWS0 2 +Myofilament 0.5041523562045307 0.4495354725160359 0.6530454249402453 1.0 0.9083583402335952 4 P67936,P09493 2 +Striated muscle thin filament 0.5041523562045307 0.4495354725160359 0.6530454249402453 1.0 0.9083583402335952 4 P67936,P09493 2 +Plasma membrane protein complex 0.2869322816444634 0.4449171422811382 0.6563796339412664 1.0 0.9083598469797756 61 P41440,P05026,P08195,Q92542,O43464,P04439,P04899,P10321,Q9NR28,P05023,O00560,P05556,P49755,P01889,P62993,P54709,Q14118,P02786,O75955,Q13546,P25054 21 +Intrinsic component of postsynaptic specialization membrane 0.5006509433285159 0.4368331816903198 0.6622323329509534 1.0 0.9084612524168 4 P23634 1 +Prc1 complex 0.6516998075689504 0.4343307386953132 0.6640482853477945 1.0 0.908803242485048 2 Q99496 1 +Endoplasmic reticulum exit site 0.3408373780648596 0.4180756632272111 0.6758917978562162 1.0 0.9192258508289772 18 P04439,Q5JRA6,Q96PC5,Q9NR31,Q9Y3A6 5 +Myelin sheath abaxonal region 0.4507223113964724 0.4171167493648156 0.6765930142767842 1.0 0.9192258508289772 5 Q12959,P05556,Q14160,P09543 4 +Proton transporting atp synthase complex catalytic core f 1 0.4937798895948857 0.4122386499050705 0.6801645108570527 1.0 0.9192258508289772 4 P06576 1 +Ikappab kinase complex 0.643681847338033 0.4097109847852371 0.6820179710653211 1.0 0.9195063717041384 2 Q8IUD2 1 +Smooth endoplasmic reticulum 0.3941957896125252 0.3978758269048126 0.6907217195082667 1.0 0.9215902337238008 9 O00264,P27824 2 +Intrinsic component of postsynaptic density membrane 0.6109238716913004 0.3876321394142207 0.698288281221561 1.0 0.9222291294267264 3 P23634 1 +Nucleoid 0.3033946749748437 0.3781705567061044 0.7053038964907841 1.0 0.9247544576275692 35 P21796,P45880,Q9NVI7 3 +Clathrin coated vesicle membrane 0.3159486302074393 0.3614058365241351 0.7177960855294256 1.0 0.9297655932830718 25 O43493,Q14108,Q9NY64 3 +Escrt complex 0.3782264201133931 0.3581447018795579 0.7202350274953213 1.0 0.930860106862712 10 Q92783,Q9Y3E7,Q9H9H4,Q9UQN3 4 +Endoplasmic reticulum quality control compartment 0.4201124334142853 0.3469106976154938 0.7286584096319961 1.0 0.9364035732292036 6 P27824 1 +Nuclear pore central transport channel 0.4673115129330654 0.3220329410839231 0.7474277393206765 1.0 0.9478674412150734 4 Q8NFH5 1 +Mrna cleavage factor complex 0.3628176262463773 0.32122342403091 0.7480410821951187 1.0 0.9478674412150734 11 P33240,Q92797,Q05048,O43809,Q10570,Q8N684,Q6UN15,Q5KU26,Q9P2I0,Q9UKF6 10 +Tight junction 0.3063683389676567 0.3104840137939232 0.7561929143812929 1.0 0.9528661758406834 27 P78310,Q16625,Q86UE4 3 +Golgi apparatus 0.4496532166652912 0.303256675194166 0.7616942606310153 1.0 0.9550215234528364 312 O14773,Q7LGA3,Q8N4V1,Q8NBN3,P61026,Q9P2W9,Q9UQB8,Q8NEY8,Q14108,P80303,Q02818,P50897,O15127,Q10713,Q9NX62,Q8NCH0,O95197,P24390,O75503,O60499,O95249,Q9Y282,Q93050,O43505,Q96A57,Q8IV08,Q92520,Q5VW38,P16278,Q15363,O15118,P35613,Q9NX40,Q9UI14,P06280,Q8NF37,Q10472,Q9BUR5,Q92542,Q8TAD4,Q5BJH7,Q96JB2,Q11206,Q7RTS9,Q99805,Q8TB61,P05023,O95721,P49755,Q9H4A6,O95070,O43493,Q9H7Z7,Q8TBA6,P04062,Q96L58,O15260,Q12770,P98194,Q9H6R6,P10321,Q9H0U4,L0R6Q1,P51572,O43852,P35670,P20645,Q9Y371,Q8TD16,Q14118,P51790,Q9Y3B3,P52292,Q92896,Q9BZG1,Q8IY95,Q9UM00,Q04656,Q9NTJ5,Q15392,Q8N2A8,Q9Y3E0,Q9Y3A6,Q6NUQ4,Q9BSR8,Q9NR31,O43752,Q96M27,O60476,Q96A49,Q9BTV4,Q6ZRP7,Q16799,Q99640,O14828 95 +Nbaf complex 0.3817480719794339 0.302707355276202 0.7621128919331963 1.0 0.9550215234528364 8 Q969G3,P51532,Q8TAQ2,Q92922,Q12824,Q96GM5,Q92785 7 +Calcium channel complex 0.4081860966400801 0.2985516676074025 0.7652821479324052 1.0 0.9550215234528364 6 Q8NE86,Q9BPX6 2 +Ubiquitin conjugating enzyme complex 0.4486521181001376 0.2633441863985206 0.7922853053854635 1.0 0.9728374747407076 4 O75150,P61088,Q5VTR2 3 +Npbaf complex 0.3664416586306581 0.2631385774970008 0.7924437708152783 1.0 0.9728374747407076 9 Q969G3,P51532,O14497,Q8TAQ2,O96019,Q92922,Q12824,Q96GM5 8 +Hulc complex 0.585311096856966 0.251872845932843 0.801139348872423 1.0 0.9783898177989526 2 O75150 1 +Mrna cleavage and polyadenylation specificity factor complex 0.3625843780134936 0.2452977558009416 0.8062258892921095 1.0 0.9796198102050724 9 P33240,Q92797,Q10570,O43809,Q8N684,Q6UN15,Q9P2I0,Q9UKF6 8 +Dendritic shaft 0.4040929985181481 0.2431425445872146 0.807894974095424 1.0 0.9796198102050724 5 Q14168 1 +Amphisome 0.3853066211006455 0.240395167964779 0.8100239238011331 1.0 0.9796198102050724 7 Q13501,Q9Y3E7,Q9UQN3 3 +Male germ cell nucleus 0.4391187683990177 0.235112482652159 0.8141214304731466 1.0 0.9796198102050724 4 Q15645 1 +Gtpase complex 0.3996789727126849 0.2281850754300285 0.8195023634863821 1.0 0.9807182089455176 5 P04899,Q14344,P09471,P63096 4 +Golgi associated vesicle membrane 0.3167920014779347 0.226885746877145 0.8205125854091637 1.0 0.9807182089455176 17 P24390 1 +Mcrd mediated mrna stability complex 0.4298167048060131 0.2087872288203178 0.8346143415520859 1.0 0.991199586990728 4 O60506 1 +Postsynaptic cytosol 0.383545974931808 0.2047875625778077 0.8377381047058867 1.0 0.991199586990728 6 Q14118 1 +Main axon 0.339414779606548 0.2011688919731393 0.8405665148463064 1.0 0.991199586990728 11 Q14168,P04350,Q14118,Q8IXJ6 4 +Messenger ribonucleoprotein complex 0.425719354449871 0.1975882610201509 0.8433672200802644 1.0 0.991199586990728 4 Q99729,P67809 2 +Outer kinetochore 0.3894060995184625 0.1945445646417509 0.8457495046911896 1.0 0.991199586990728 5 Q8IX90,Q96EA4,P53350,O60566 4 +Immunological synapse 0.3242782722811386 0.1939903114316346 0.8461834681596909 1.0 0.991199586990728 14 O15400 1 +Beta catenin tcf complex 0.5583707504810715 0.1932203498811877 0.8467864021311517 1.0 0.991199586990728 2 P35222 1 +Nuclear inclusion body 0.3557197943444777 0.1891372906340048 0.8499852152171536 1.0 0.9936601354667628 8 O60934,P12270,Q9UBU9,Q86U42,P49792,Q9UNE7,P52948 7 +Cell tip 0.5542014111609971 0.1850009916428984 0.8532282577812664 1.0 0.9948839144785424 2 Q9BTU6 1 +Spectrin 0.4188061617458304 0.1792588239027705 0.8577344768661688 1.0 0.9980680780353772 4 O43491,Q13813,Q01082 3 +Cell trailing edge 0.3746116094202331 0.1731129365188497 0.862562656601551 1.0 1.0 6 P41440,O75955 2 +Flotillin complex 0.3737551046305936 0.170147134826838 0.8648944256742273 1.0 1.0 6 P41440,O75955 2 +Cop9 signalosome 0.3388037524143712 0.166324190570953 0.867901829859892 1.0 1.0 10 Q9BT78,Q99627 2 +Sperm midpiece 0.3707246497401933 0.1597559025780602 0.8730733624734508 1.0 1.0 6 Q15388,Q13501 2 +Proton transporting two sector atpase complex catalytic domain 0.3355604950508349 0.1518010068118553 0.8793438880175142 1.0 1.0 10 P06576,P36543,Q15904 3 +Xy body 0.4066110397946126 0.1487067575591615 0.8817850287705744 1.0 1.0 4 Q92922,P16104,O75182 3 +Sperm annulus 0.5333547145606112 0.1473962414148688 0.8828192720382957 1.0 1.0 2 Q15019 1 +Dense core granule 0.5098159090406471 0.1418312694012623 0.8872132843265492 1.0 1.0 3 Q709C8 1 +Trans golgi network transport vesicle 0.3188450281918754 0.1400133523820012 0.8886494406345402 1.0 1.0 13 P11717,O43493,P49755,Q04656 4 +Ciliary transition zone 0.3585959523557261 0.1360777765942056 0.8917597958014278 1.0 1.0 7 P41208,A6NIH7,Q15154 3 +Ragulator complex 0.5262989095574016 0.1359834068286399 0.8918343985408399 1.0 1.0 2 Q6IAA8 1 +Vesicle membrane 0.4039274828274742 0.135338098913538 0.8923445635909486 1.0 1.0 250 Q8N668,Q9UBV8,Q8N4V1,P61026,Q15907,Q14728,Q13190,O95772,Q14108,Q07065,O60831,P30519,Q9Y3E7,P42785,O15127,Q12846,Q969Q5,Q8NHP6,P24390,Q9H0U3,P11717,P05556,O60499,O43924,Q9H9H4,Q93050,P42892,Q92783,Q8WTV0,Q8IV08,Q96PE3,Q4KMQ2,P02786,O00264,Q9Y487,O15400,Q15363,O15118,P35613,Q8NF37,Q92542,Q8TAD4,Q9UIQ6,Q9NY64,Q15904,O60749,Q99805,Q08722,Q9NZC3,O95721,O43760,P49755,Q9NZJ7,P13473,Q9Y5X3,O43493,O76024,P11279,Q5T9A4,O15260,Q12770,P10321,Q15043,P20645,P10253,Q9P253,P51790,Q9Y3B3,Q9BZG1,P20020,Q04656,Q9NR31,O43752,Q9UQN3,Q9UH99,O75787,O14828 77 +Proximal dendrite 0.5253367543296914 0.1344782393102753 0.8930244172950272 1.0 1.0 2 P49840 1 +Pseudopodium 0.3402956298200535 0.1274955106206936 0.8985482261926643 1.0 1.0 8 P51809,P27361,P09543,P28482,P26038,P12814,O43707 7 +Mpp7 dlg1 lin7 complex 0.519884541372671 0.1261792763237745 0.8995900153392888 1.0 1.0 2 Q12959 1 +Cytoplasmic side of endoplasmic reticulum membrane 0.3658494232729737 0.12406045652666 0.9012674073403996 1.0 1.0 5 Q8TCT9 1 +Swi snf complex 0.3346190935390462 0.1240012428798335 0.9013142909836868 1.0 1.0 9 P51532,O14497,Q8TAQ2,Q92922,O96019,Q969G3,Q12824,Q96GM5 8 +Endosome 0.3769530942561466 0.1222756476805694 0.9026807175970216 1.0 1.0 209 Q8N668,O14773,P41440,Q8N4V1,P61026,Q15907,P18031,O95772,Q14108,Q13510,O60831,P35232,Q9Y3E7,O15127,Q12846,Q969Q5,Q9BRK5,P11717,P05556,Q9H9H4,Q93050,P42892,Q92783,Q96A57,Q92544,Q8IV08,Q96PE3,Q5VW38,P02786,O75955,Q9Y487,O15400,O15118,P35613,Q9NX40,P31751,Q13501,Q92542,Q9H4M9,Q8IZ07,Q9UIQ6,O60826,Q15904,P04439,O60749,Q99805,Q86Y82,Q9HD42,Q9H223,Q9H4A6,O15126,Q9NZJ7,Q9BXB4,P61020,P01889,P27361,P36543,P13473,Q9Y5X3,P62993,O43493,Q13546,P11279,P10321,Q15043,P35670,P20645,Q9P253,Q9BUN8,P51790,Q8IY95,Q04656,O43752,Q9UQN3,Q9UH99,O75787,O14828 77 +Tertiary granule membrane 0.3171681566699659 0.1123085928177 0.9105787288269668 1.0 1.0 12 O75787,Q08722,P10253 3 +Postsynaptic endocytic zone 0.5044900577293104 0.1048309760998132 0.9165099300914265 1.0 1.0 2 P09496 1 +Nuclear ubiquitin ligase complex 0.3022074360477871 0.1027382934099402 0.9181706806903576 1.0 1.0 15 Q9UJX6,O60566,Q9UJX4,P30260,Q99496,Q16763,Q9UJX3,Q9UJX5,Q8IXK0 9 +Transcription preinitiation complex 0.3832988872094257 0.0968854603673777 0.922817355428319 1.0 1.0 4 P29083 1 +Filopodium membrane 0.4815527751042787 0.0949467062730597 0.924357157821385 1.0 1.0 3 P46939,Q8WXH0 2 +Rna polymerase ii transcription repressor complex 0.4767404555662612 0.0879583107744196 0.9299098108477728 1.0 1.0 3 Q01658,P35222 2 +Cytolytic granule 0.3502234630207071 0.0828294839433154 0.9339871248775722 1.0 1.0 5 Q01085,P11279 2 +9plus2 motile cilium 0.2778111345932957 0.0707008077413061 0.9436358779634564 1.0 1.0 24 P05026,Q15388,P05023,Q13501,P41208,P23634,P54709,Q13099,Q96RL7 9 +Cytoplasmic side of endosome membrane 0.4557408595253347 0.0560658976895055 0.95528931088953 1.0 1.0 2 P20339 1 +Nlrp3 inflammasome complex 0.4522129570237252 0.0535345012003248 0.9573060420690264 1.0 1.0 2 Q9H6R0 1 +Inflammasome complex 0.4522129570237252 0.0535345012003248 0.9573060420690264 1.0 1.0 2 Q9H6R0 1 +Growth cone membrane 0.450288646568307 0.0522042797445123 0.958365922842678 1.0 1.0 2 Q9UPT5 1 +Gap junction 0.3571887034659841 0.0494022416640597 0.9605987417555673 1.0 1.0 4 Q07157,Q99797,Q69YQ0 3 +Pericentriolar material 0.3478818998716338 0.0351661458752346 0.9719472572029472 1.0 1.0 4 Q96SN8,P17987,Q15154 3 +Chromaffin granule membrane 0.4188582424631114 0.0350490926751001 0.9720405946050747 1.0 1.0 2 P20073 1 +Chromaffin granule 0.4188582424631114 0.0350490926751001 0.9720405946050747 1.0 1.0 2 P20073 1 +Equatorial microtubule organizing center 0.412764592687614 0.0326059623547174 0.9739888150886178 1.0 1.0 2 Q9BSJ2 1 +Neuronal dense core vesicle 0.4047466324566977 0.0297625634150398 0.9762564155977628 1.0 1.0 2 Q96RL7 1 +Chromatoid body 0.3980115458627306 0.0276742179070079 0.9779219869554454 1.0 1.0 2 Q08J23 1 +9plus0 non motile cilium 0.2998179882879278 0.0080762998346168 0.993556115105758 1.0 1.0 10 P35613 1 diff --git a/msigdb_gocc/selections.json b/msigdb_gocc/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f3d088c5d2376dcce8107c654c4abc2cd9e32f25 --- /dev/null +++ b/msigdb_gocc/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["90s preribosome", "9plus0 non motile cilium", "9plus2 motile cilium", "A band", "Acrosomal membrane", "Acrosomal vesicle", "Actin based cell projection", "Actin cytoskeleton", "Actin filament", "Actin filament bundle", "Actomyosin", "Adherens junction", "Aggresome", "Alpha dna polymerase primase complex", "Alveolar lamellar body", "Aminoacyl trna synthetase multienzyme complex", "Ampa glutamate receptor complex", "Amphisome", "Amphisome membrane", "Anaphase promoting complex", "Anchored component of membrane", "Anchored component of plasma membrane", "Anchored component of postsynaptic membrane", "Anchored component of synaptic membrane", "Anchored component of synaptic vesicle membrane", "Anchoring junction", "Annulate lamellae", "Ap 1 adaptor complex", "Ap 3 adaptor complex", "Ap type membrane coat adaptor complex", "Apical dendrite", "Apical junction complex", "Apical part of cell", "Apical plasma membrane", "Apicolateral plasma membrane", "Arp2 3 protein complex", "Aryl hydrocarbon receptor complex", "Aster", "Astrocyte end foot", "Astrocyte projection", "Atac complex", "Atg1 ulk1 kinase complex", "Atpase complex", "Atpase dependent transmembrane transport complex", "Autolysosome", "Autophagosome", "Autophagosome membrane", "Axolemma", "Axon", "Axon cytoplasm", "Axon hillock", "Axon initial segment", "Axonal growth cone", "Axonemal microtubule", "Azurophil granule", "Azurophil granule lumen", "Azurophil granule membrane", "B wich complex", "Barr body", "Basal cortex", "Basal dendrite", "Basal part of cell", "Basement membrane", "Basolateral plasma membrane", "Bcl 2 family protein complex", "Beta catenin destruction complex", "Beta catenin tcf complex", "Bleb", "Bloc 1 complex", "Bloc complex", "Blood microparticle", "Borc complex", "Box c d rnp complex", "Box h aca rnp complex", "Box h aca snornp complex", "Box h aca telomerase rnp complex", "Brca1 a complex", "Brca1 c complex", "Brisc complex", "Brush border", "Brush border membrane", "Cajal body", "Calcium and calmodulin dependent protein kinase complex", "Calcium channel complex", "Camp dependent protein kinase complex", "Carboxy terminal domain protein kinase complex", "Caspase complex", "Catalytic complex", "Catalytic step 1 spliceosome", "Catalytic step 2 spliceosome", "Catenin complex", "Cation channel complex", "Cation transporting atpase complex", "Catsper complex", "Caveola", "Cbm complex", "Ccaat binding factor complex", "Ccr4 not complex", "Ccr4 not core complex", "Cd40 receptor complex", "Cd95 death inducing signaling complex", "Cdc73 paf1 complex", "Cell body", "Cell body membrane", "Cell cell contact zone", "Cell cell junction", "Cell cortex", "Cell cortex region", "Cell division site", "Cell leading edge", "Cell pole", "Cell projection membrane", "Cell substrate junction", "Cell surface", "Cell tip", "Cell trailing edge", "Central element", "Centriolar satellite", "Centriolar subdistal appendage", "Centriole", "Centrosome", "Cerebellar mossy fiber", "Chaperone complex", "Chaperonin containing t complex", "Checkpoint clamp complex", "Chitosome", "Chloride channel complex", "Cholinergic synapse", "Chromaffin granule", "Chromaffin granule membrane", "Chromatin", "Chromatin silencing complex", "Chromatoid body", "Chromocenter", "Chromosomal region", "Chromosome", "Chromosome centromeric core domain", "Chromosome centromeric region", "Chromosome passenger complex", "Chromosome telomeric region", "Chromosome telomeric repeat region", "Cia complex", "Ciliary basal body", "Ciliary base", "Ciliary membrane", "Ciliary plasm", "Ciliary rootlet", "Ciliary tip", "Ciliary transition zone", "Cilium", "Cis golgi network", "Cis golgi network membrane", "Clathrin adaptor complex", "Clathrin coat", "Clathrin coat of coated pit", "Clathrin coat of endocytic vesicle", "Clathrin coated endocytic vesicle", "Clathrin coated endocytic vesicle membrane", "Clathrin coated pit", "Clathrin coated vesicle", "Clathrin coated vesicle membrane", "Clathrin complex", "Clathrin sculpted gamma aminobutyric acid transport vesicle", "Clathrin sculpted vesicle", "Clathrin vesicle coat", "Cleavage furrow", "Cluster of actin based cell projections", "Coated vesicle", "Coated vesicle membrane", "Cohesin complex", "Collagen containing extracellular matrix", "Collagen trimer", "Commitment complex", "Compact myelin", "Condensed chromosome", "Condensed chromosome centromeric region", "Condensed nuclear chromosome", "Condensin complex", "Contractile fiber", "Contractile ring", "Cop9 signalosome", "Copi coated vesicle", "Copi coated vesicle membrane", "Copi vesicle coat", "Copii coated er to golgi transport vesicle", "Copii vesicle coat", "Core mediator complex", "Cornified envelope", "Cortical actin cytoskeleton", "Cortical cytoskeleton", "Cortical endoplasmic reticulum", "Cortical granule", "Costamere", "Crd mediated mrna stability complex", "Ctf18 rfc like complex", "Cul2 ring ubiquitin ligase complex", "Cul3 ring ubiquitin ligase complex", "Cul4 ring e3 ubiquitin ligase complex", "Cul4a ring e3 ubiquitin ligase complex", "Cul4b ring e3 ubiquitin ligase complex", "Cul5 ring ubiquitin ligase complex", "Cullin ring ubiquitin ligase complex", "Cuticular plate", "Cyclin a2 cdk2 complex", "Cyclin cdk positive transcription elongation factor complex", "Cyclin dependent protein kinase holoenzyme complex", "Cytochrome complex", "Cytolytic granule", "Cytoplasmic dynein complex", "Cytoplasmic exosome rnase complex", "Cytoplasmic microtubule", "Cytoplasmic region", "Cytoplasmic side of endoplasmic reticulum membrane", "Cytoplasmic side of endosome membrane", "Cytoplasmic side of lysosomal membrane", "Cytoplasmic side of membrane", "Cytoplasmic stress granule", "Cytoplasmic ubiquitin ligase complex", "Cytoskeleton of presynaptic active zone", "Cytosolic large ribosomal subunit", "Cytosolic region", "Cytosolic ribosome", "Cytosolic small ribosomal subunit", "Death inducing signaling complex", "Dendrite cytoplasm", "Dendrite membrane", "Dendrite terminus", "Dendritic growth cone", "Dendritic shaft", "Dendritic spine head", "Dendritic spine membrane", "Dendritic tree", "Dense body", "Dense core granule", "Dense core granule membrane", "Dentate gyrus mossy fiber", "Derlin 1 retrotranslocation complex", "Desmosome", "Dihydrolipoyl dehydrogenase complex", "Distal axon", "Dna packaging complex", "Dna polymerase complex", "Dna repair complex", "Dna replication factor c complex", "Dna replication preinitiation complex", "Dopaminergic synapse", "Dynactin complex", "Dynein axonemal particle", "Dynein complex", "Dystroglycan complex", "Dystrophin associated glycoprotein complex", "Early endosome", "Early endosome lumen", "Early endosome membrane", "Early phagosome", "Ekc keops complex", "Elongator holoenzyme complex", "Elongin complex", "Emc complex", "Endocytic vesicle", "Endocytic vesicle lumen", "Endocytic vesicle membrane", "Endolysosome", "Endolysosome membrane", "Endopeptidase complex", "Endoplasmic reticulum", "Endoplasmic reticulum chaperone complex", "Endoplasmic reticulum exit site", "Endoplasmic reticulum golgi intermediate compartment", "Endoplasmic reticulum golgi intermediate compartment membrane", "Endoplasmic reticulum lumen", "Endoplasmic reticulum palmitoyltransferase complex", "Endoplasmic reticulum plasma membrane contact site", "Endoplasmic reticulum protein containing complex", "Endoplasmic reticulum quality control compartment", "Endoplasmic reticulum tubular network", "Endoplasmic reticulum tubular network membrane", "Endoribonuclease complex", "Endosome", "Endosome lumen", "Endosome membrane", "Envelope", "Enzyme activator complex", "Epsilon dna polymerase complex", "Equatorial microtubule organizing center", "Er membrane insertion complex", "Er to golgi transport vesicle membrane", "Er ubiquitin ligase complex", "Esc e z complex", "Escrt complex", "Escrt i complex", "Escrt iii complex", "Euchromatin", "Eukaryotic translation initiation factor 2 complex", "Eukaryotic translation initiation factor 2b complex", "Eukaryotic translation initiation factor 3 complex", "Eukaryotic translation initiation factor 3 complex eif3m", "Eukaryotic translation initiation factor 4f complex", "Excitatory synapse", "Exocyst", "Exocytic vesicle", "Exon exon junction complex", "Exoribonuclease complex", "External encapsulating structure", "External side of apical plasma membrane", "External side of plasma membrane", "Extrinsic component of cytoplasmic side of plasma membrane", "Extrinsic component of endoplasmic reticulum membrane", "Extrinsic component of endosome membrane", "Extrinsic component of external side of plasma membrane", "Extrinsic component of membrane", "Extrinsic component of mitochondrial inner membrane", "Extrinsic component of organelle membrane", "Extrinsic component of plasma membrane", "Extrinsic component of postsynaptic membrane", "Extrinsic component of postsynaptic specialization membrane", "Extrinsic component of synaptic membrane", "F actin capping protein complex", "Fascia adherens", "Female germ cell nucleus", "Female pronucleus", "Fibrillar center", "Ficolin 1 rich granule", "Ficolin 1 rich granule lumen", "Ficolin 1 rich granule membrane", "Filamentous actin", "Filopodium", "Filopodium membrane", "Filopodium tip", "Filtration diaphragm", "Flemming body", "Flotillin complex", "Gaba ergic synapse", "Gamma secretase complex", "Gamma tubulin complex", "Gamma tubulin large complex", "Gap junction", "Gator2 complex", "Gemini of coiled bodies", "Germ cell nucleus", "Gid complex", "Glial cell projection", "Glutamatergic synapse", "Glycinergic synapse", "Glycogen granule", "Glycoprotein complex", "Golgi apparatus", "Golgi apparatus subcompartment", "Golgi associated vesicle", "Golgi associated vesicle membrane", "Golgi cis cisterna", "Golgi cisterna", "Golgi cisterna membrane", "Golgi lumen", "Golgi medial cisterna", "Golgi membrane", "Golgi stack", "Golgi transport complex", "Gpi anchor transamidase complex", "Granular component", "Growth cone membrane", "Gtpase complex", "Guanyl nucleotide exchange factor complex", "H3 histone acetyltransferase complex", "H4 h2a histone acetyltransferase complex", "H4 histone acetyltransferase complex", "Haus complex", "Hemidesmosome", "Hemoglobin complex", "Heterochromatin", "Hfe transferrin receptor complex", "High density lipoprotein particle", "Hippocampal mossy fiber", "Hippocampal mossy fiber to ca3 synapse", "Histone deacetylase complex", "Histone methyltransferase complex", "Histone pre mrna 3 end processing complex", "Hops complex", "Host cellular component", "Hrd1p ubiquitin ligase erad l complex", "Hulc complex", "I band", "Ikappab kinase complex", "Immunological synapse", "Inclusion body", "Inflammasome complex", "Inhibitory synapse", "Inner mitochondrial membrane protein complex", "Ino80 complex", "Ino80 type complex", "Insulin responsive compartment", "Integral component of cytoplasmic side of endoplasmic reticulum membrane", "Integral component of lysosomal membrane", "Integral component of presynaptic active zone membrane", "Integral component of synaptic vesicle membrane", "Integrator complex", "Integrin complex", "Intercalated disc", "Intercellular bridge", "Intercellular canaliculus", "Intermediate filament", "Intermediate filament cytoskeleton", "Intracellular protein containing complex", "Intraciliary transport particle", "Intraciliary transport particle b", "Intrinsic component of endoplasmic reticulum membrane", "Intrinsic component of golgi membrane", "Intrinsic component of mitochondrial inner membrane", "Intrinsic component of mitochondrial membrane", "Intrinsic component of mitochondrial outer membrane", "Intrinsic component of nuclear inner membrane", "Intrinsic component of organelle membrane", "Intrinsic component of peroxisomal membrane", "Intrinsic component of plasma membrane", "Intrinsic component of postsynaptic density membrane", "Intrinsic component of postsynaptic membrane", "Intrinsic component of postsynaptic specialization membrane", "Intrinsic component of presynaptic active zone membrane", "Intrinsic component of presynaptic membrane", "Intrinsic component of synaptic membrane", "Intrinsic component of synaptic vesicle membrane", "Intrinsic component of vacuolar membrane", "Ion channel complex", "Iron sulfur cluster assembly complex", "Iswi type complex", "Juxtaparanode region of axon", "Keratin filament", "Kinesin complex", "Kinetochore microtubule", "Lamellar body", "Lamellipodium", "Lamellipodium membrane", "Lamin filament", "Laminin complex", "Large ribosomal subunit", "Late endosome", "Late endosome membrane", "Lateral element", "Lateral part of cell", "Lateral plasma membrane", "Leading edge membrane", "Lewy body", "Lipid droplet", "Lipopolysaccharide receptor complex", "Low density lipoprotein particle", "Lsm1 7 pat1 complex", "Lsm2 8 complex", "Lumenal side of endoplasmic reticulum membrane", "Lumenal side of membrane", "Lysosomal lumen", "M band", "Magnesium dependent protein serine threonine phosphatase complex", "Main axon", "Male germ cell nucleus", "Male pronucleus", "Manchette", "Mcm complex", "Mcrd mediated mrna stability complex", "Mediator complex", "Meiotic cohesin complex", "Meiotic spindle", "Membrane coat", "Membrane microdomain", "Membrane protein complex", "Messenger ribonucleoprotein complex", "Methylosome", "Methyltransferase complex", "Mhc class i peptide loading complex", "Mhc class i protein complex", "Mhc protein complex", "Mib complex", "Micos complex", "Microbody", "Microbody lumen", "Microbody membrane", "Microfibril", "Microtubule", "Microtubule associated complex", "Microtubule bundle", "Microtubule cytoskeleton", "Microtubule end", "Microtubule minus end", "Microtubule organizing center", "Microtubule organizing center attachment site", "Microtubule plus end", "Microvillus", "Microvillus membrane", "Midbody", "Mismatch repair complex", "Mitochondria associated endoplasmic reticulum membrane", "Mitochondrial alpha ketoglutarate dehydrogenase complex", "Mitochondrial crista", "Mitochondrial envelope", "Mitochondrial intermembrane space protein transporter complex", "Mitochondrial large ribosomal subunit", "Mitochondrial matrix", "Mitochondrial permeability transition pore complex", "Mitochondrial protein containing complex", "Mitochondrial proton transporting atp synthase complex coupling factor f o", "Mitochondrial pyruvate dehydrogenase complex", "Mitochondrial small ribosomal subunit", "Mitochondrial tricarboxylic acid cycle enzyme complex", "Mitochondrion", "Mitotic cohesin complex", "Mitotic spindle", "Mitotic spindle astral microtubule", "Mitotic spindle microtubule", "Mitotic spindle midzone", "Mitotic spindle pole", "Mks complex", "Mll1 2 complex", "Mll3 4 complex", "Mmxd complex", "Mon1 ccz1 complex", "Motile cilium", "Mpp7 dlg1 lin7 complex", "Mrna cleavage and polyadenylation specificity factor complex", "Mrna cleavage factor complex", "Mrna editing complex", "Multimeric ribonuclease p complex", "Multivesicular body", "Multivesicular body membrane", "Myelin sheath", "Myelin sheath abaxonal region", "Myelin sheath adaxonal region", "Myofilament", "Myosin complex", "Myosin filament", "Myosin ii complex", "N terminal protein acetyltransferase complex", "Nadh dehydrogenase complex", "Nascent polypeptide associated complex", "Nata complex", "Nbaf complex", "Neurofibrillary tangle", "Neurofilament", "Neuromuscular junction", "Neuron projection", "Neuron projection cytoplasm", "Neuron projection membrane", "Neuron projection terminus", "Neuron spine", "Neuron to neuron synapse", "Neuronal dense core vesicle", "Neuronal dense core vesicle membrane", "Neuronal ribonucleoprotein granule", "Neurotransmitter receptor complex", "Nlrp3 inflammasome complex", "Nls dependent protein nuclear import complex", "Node of ranvier", "Non motile cilium", "Nonhomologous end joining complex", "Npbaf complex", "Nsl complex", "Nuclear body", "Nuclear chromosome", "Nuclear cyclin dependent protein kinase holoenzyme complex", "Nuclear envelope", "Nuclear envelope lumen", "Nuclear exosome rnase complex", "Nuclear inclusion body", "Nuclear inner membrane", "Nuclear lamina", "Nuclear membrane", "Nuclear outer membrane", "Nuclear outer membrane endoplasmic reticulum membrane network", "Nuclear periphery", "Nuclear pore", "Nuclear pore central transport channel", "Nuclear pore nuclear basket", "Nuclear pore outer ring", "Nuclear protein containing complex", "Nuclear replication fork", "Nuclear rna export factor complex", "Nuclear speck", "Nuclear stress granule", "Nuclear ubiquitin ligase complex", "Nucleocytoplasmic transport complex", "Nucleoid", "Nucleolar ribonuclease p complex", "Nucleolus", "Nucleotide activated protein kinase complex", "Nucleotide excision repair complex", "Nurd complex", "Nurf complex", "Oligosaccharyltransferase complex", "Organellar ribosome", "Organelle envelope lumen", "Organelle inner membrane", "Organelle membrane contact site", "Organelle subcompartment", "Origin recognition complex", "Outer dense fiber", "Outer kinetochore", "Outer membrane", "Outer mitochondrial membrane protein complex", "Oxidoreductase complex", "Oxoglutarate dehydrogenase complex", "P body", "Palmitoyltransferase complex", "Pam complex tim23 associated import motor", "Parallel fiber to purkinje cell synapse", "Paranodal junction", "Paranode region of axon", "Paraspeckles", "Pcg protein complex", "Peptidase complex", "Peptidase inhibitor complex", "Pericentric heterochromatin", "Pericentriolar material", "Perikaryon", "Perinuclear endoplasmic reticulum", "Perinuclear region of cytoplasm", "Perinucleolar compartment", "Phagocytic cup", "Phagocytic vesicle", "Phagocytic vesicle lumen", "Phagocytic vesicle membrane", "Phagolysosome", "Phagophore assembly site", "Phagophore assembly site membrane", "Phosphatase complex", "Phosphatidylinositol 3 kinase complex", "Phosphatidylinositol 3 kinase complex class i", "Phosphatidylinositol 3 kinase complex class ia", "Photoreceptor connecting cilium", "Photoreceptor inner segment", "Photoreceptor outer segment", "Photoreceptor ribbon synapse", "Picln sm protein complex", "Pigment granule", "Pinosome", "Plasma membrane protein complex", "Plasma membrane raft", "Plasma membrane region", "Plasma membrane signaling receptor complex", "Platelet alpha granule", "Platelet alpha granule lumen", "Platelet alpha granule membrane", "Platelet dense granule", "Platelet dense granule lumen", "Platelet dense granule membrane", "Platelet dense tubular network", "Platelet dense tubular network membrane", "Pml body", "Podosome", "Polar microtubule", "Pole plasm", "Polymeric cytoskeletal fiber", "Polysomal ribosome", "Polysome", "Pore complex", "Post mrna release spliceosomal complex", "Postsynapse", "Postsynaptic cytoskeleton", "Postsynaptic cytosol", "Postsynaptic density intracellular component", "Postsynaptic density membrane", "Postsynaptic endocytic zone", "Postsynaptic endosome", "Postsynaptic membrane", "Postsynaptic recycling endosome", "Postsynaptic specialization intracellular component", "Postsynaptic specialization membrane", "Potassium channel complex", "Prc1 complex", "Pre snornp complex", "Precatalytic spliceosome", "Prefoldin complex", "Preribosome", "Preribosome large subunit precursor", "Preribosome small subunit precursor", "Prespliceosome", "Presynapse", "Presynaptic active zone", "Presynaptic active zone cytoplasmic component", "Presynaptic active zone membrane", "Presynaptic cytoskeleton", "Presynaptic cytosol", "Presynaptic endocytic zone", "Presynaptic membrane", "Pronucleus", "Protease inhibitor complex", "Proteasome accessory complex", "Proteasome complex", "Proteasome core complex", "Proteasome core complex alpha subunit complex", "Proteasome core complex beta subunit complex", "Proteasome regulatory particle", "Proteasome regulatory particle base subcomplex", "Proteasome regulatory particle lid subcomplex", "Protein acetyltransferase complex", "Protein complex involved in cell adhesion", "Protein dna complex", "Protein kinase complex", "Protein lipid complex", "Protein phosphatase 4 complex", "Protein phosphatase type 1 complex", "Protein phosphatase type 2a complex", "Proton transporting atp synthase complex", "Proton transporting atp synthase complex catalytic core f 1", "Proton transporting atp synthase complex coupling factor f o", "Proton transporting two sector atpase complex", "Proton transporting two sector atpase complex catalytic domain", "Proton transporting two sector atpase complex proton transporting domain", "Proton transporting v type atpase complex", "Proton transporting v type atpase v0 domain", "Proton transporting v type atpase v1 domain", "Proximal dendrite", "Prp19 complex", "Pseudopodium", "Ptw pp1 phosphatase complex", "Pwp2p containing subcomplex of 90s preribosome", "R2tp complex", "Ragulator complex", "Rdna heterochromatin", "Receptor complex", "Recycling endosome", "Recycling endosome membrane", "Replication fork", "Replisome", "Respirasome", "Respiratory chain complex iii", "Respiratory chain complex iv", "Retromer complex", "Ribbon synapse", "Ribonuclease mrp complex", "Ribonuclease p complex", "Ribonucleoprotein complex", "Ribonucleoprotein granule", "Ribose phosphate diphosphokinase complex", "Ribosomal subunit", "Ribosome", "Ripoptosome", "Risc loading complex", "Rna cap binding complex", "Rna polymerase complex", "Rna polymerase i complex", "Rna polymerase ii core complex", "Rna polymerase ii holoenzyme", "Rna polymerase ii transcription regulator complex", "Rna polymerase ii transcription repressor complex", "Rna polymerase iii complex", "Rna polymerase iii transcription regulator complex", "Rnai effector complex", "Rough endoplasmic reticulum", "Rough endoplasmic reticulum membrane", "Rpap3 r2tp prefoldin like complex", "Ruffle", "Ruffle membrane", "Saga complex", "Saga type complex", "Sarcolemma", "Sarcoplasm", "Sarcoplasmic reticulum lumen", "Sarcoplasmic reticulum membrane", "Scar complex", "Scf ubiquitin ligase complex", "Schaffer collateral ca1 synapse", "Schmidt lanterman incisure", "Sec61 translocon complex", "Secondary lysosome", "Secretory granule", "Secretory granule membrane", "Secretory vesicle", "Seh1 associated complex", "Semaphorin receptor complex", "Septin cytoskeleton", "Serine protease inhibitor complex", "Serine type endopeptidase complex", "Serine type peptidase complex", "Set1c compass complex", "Sex chromatin", "Sex chromosome", "Shelterin complex", "Side of membrane", "Signal peptidase complex", "Signal recognition particle", "Sin3 complex", "Sin3 type complex", "Site of dna damage", "Site of double strand break", "Site of polarized growth", "Sm like protein family complex", "Small ribosomal subunit", "Small subunit processome", "Smc5 smc6 complex", "Smn complex", "Smn sm protein complex", "Smooth endoplasmic reticulum", "Smooth endoplasmic reticulum membrane", "Snare complex", "Sno s rna containing ribonucleoprotein complex", "Sodium potassium exchanging atpase complex", "Somatodendritic compartment", "Sorting endosome", "Spanning component of membrane", "Specific granule", "Specific granule lumen", "Specific granule membrane", "Spectrin", "Spectrin associated cytoskeleton", "Sperm annulus", "Sperm connecting piece", "Sperm fibrous sheath", "Sperm head", "Sperm head plasma membrane", "Sperm midpiece", "Sperm plasma membrane", "Sperm principal piece", "Spindle", "Spindle microtubule", "Spindle midzone", "Spindle pole", "Spindle pole centrosome", "Spliceosomal complex", "Spliceosomal snrnp complex", "Spliceosomal tri snrnp complex", "Stereocilia coupling link", "Stereocilium bundle", "Stereocilium membrane", "Stereocilium tip", "Striated muscle thin filament", "Sumo ligase complex", "Supramolecular complex", "Supramolecular polymer", "Swi snf complex", "Swr1 complex", "Synapse", "Synaptic membrane", "Synaptic vesicle membrane", "Synaptonemal structure", "T tubule", "Telomerase holoenzyme complex", "Terminal bouton", "Tertiary granule", "Tertiary granule lumen", "Tertiary granule membrane", "Tetraspanin enriched microdomain", "Tho complex", "Tight junction", "Tim22 mitochondrial import inner membrane insertion complex", "Tim23 mitochondrial import inner membrane translocase complex", "Tor complex", "Torc1 complex", "Trans golgi network", "Trans golgi network membrane", "Trans golgi network transport vesicle", "Trans golgi network transport vesicle membrane", "Transcription elongation factor complex", "Transcription export complex", "Transcription export complex 2", "Transcription factor tfiid complex", "Transcription factor tfiih holo complex", "Transcription factor tfiiic complex", "Transcription factor tftc complex", "Transcription preinitiation complex", "Transcription regulator complex", "Transcription repressor complex", "Transferase complex", "Transferase complex transferring phosphorus containing groups", "Translation preinitiation complex", "Translocon complex", "Transport vesicle", "Transport vesicle membrane", "Transporter complex", "Trapp complex", "Tricarboxylic acid cycle enzyme complex", "Triglyceride rich plasma lipoprotein particle", "Trna methyltransferase complex", "Trna splicing ligase complex", "Tubular endosome", "U1 snrnp", "U12 type spliceosomal complex", "U2 snrnp", "U2 type catalytic step 2 spliceosome", "U2 type spliceosomal complex", "U2af complex", "U4 snrnp", "U5 snrnp", "U6 snrnp", "U7 snrnp", "Ubiquitin conjugating enzyme complex", "Ubiquitin ligase complex", "Unconventional myosin complex", "Uniplex complex", "Vacuolar lumen", "Vacuolar membrane", "Vacuolar proton transporting v type atpase v0 domain", "Vacuole", "Varicosity", "Vcp npl4 ufd1 aaa atpase complex", "Vesicle coat", "Vesicle lumen", "Vesicle membrane", "Vesicle tethering complex", "Voltage gated calcium channel complex", "Wash complex", "Weibel palade body", "Wnt signalosome", "X chromosome", "Xy body", "Zona pellucida receptor complex", "Zonula adherens", "Zymogen granule", "Zymogen granule membrane"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADNP", "ADPGK", "ADPRHL2", "ADSS", "AFDN", "AFG3L2", "AGFG1", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR7A2", "AKT2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALG9", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKLE2", "ANKRD13A", "ANLN", "ANO6", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APC", "APEH", "APEX1", "API5", "APMAP", "APOO", "APOOL", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARG2", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID4B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6", "ARL6IP1", "ARL6IP5", "ARL8B", "ARMC1", "ARMCX3", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC1", "ASCC2", "ASCC3", "ASF1A", "ASH2L", "ASNA1", "ASPH", "ASRGL1", "ATAD1", "ATAD3A", "ATAD3B", "ATG13", "ATG3", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATP7B", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BABAM2", "BAG2", "BAG5", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS2", "BCCIP", "BCKDK", "BCL10", "BCL2L13", "BCLAF1", "BCS1L", "BEND3", "BICD2", "BIRC6", "BLOC1S1", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPHL", "BRAP", "BRCA1", "BRD1", "BRD2", "BRD3", "BRD4", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "C12orf43", "C12orf73", "C17orf75", "C19orf70", "C1QBP", "C1orf35", "C2CD5", "CAB39", "CACYBP", "CAD", "CALCOCO1", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAMSAP3", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARS2", "CASK", "CAST", "CBFB", "CBX1", "CBX3", "CBX5", "CC2D1A", "CCAR1", "CCAR2", "CCDC12", "CCDC124", "CCDC22", "CCDC47", "CCDC8", "CCDC86", "CCDC93", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CCZ1B", "CD276", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK16", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK5RAP2", "CDK5RAP3", "CDK7", "CDK9", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPV", "CEP170", "CEP290", "CEP44", "CETN2", "CFAP20", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD4", "CHD8", "CHEK2", "CHERP", "CHID1", "CHMP1A", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHP1", "CHRAC1", "CHST14", "CIAPIN1", "CIRBP", "CISD1", "CISD2", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLTA", "CLTB", "CLTC", "CMPK1", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT3", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COASY", "COG3", "COG4", "COG7", "COG8", "COIL", "COLEC12", "COLGALT1", "COMMD1", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "COQ8A", "CORO1C", "COTL1", "COX11", "COX14", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7A2L", "COX7C", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRK", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTR9", "CTSA", "CTSC", "CTTN", "CTTNBP2NL", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUL7", "CWF19L1", "CXADR", "CXorf56", "CXorf57", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCP1B", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D5", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DERL1", "DFFA", "DGCR8", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DICER1", "DIDO1", "DIEXF", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNTTIP2", "DOCK1", "DOCK7", "DOLPP1", "DPF2", "DPM1", "DPP9", "DPYSL2", "DR1", "DRG1", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUS2", "DUSP3", "DUT", "DYM", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFHD2", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHHADH", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5A", "EIF6", "ELAC2", "ELAVL1", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC3", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "ENO2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC4", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAHD1", "FAM129B", "FAM162A", "FAM208A", "FAM210A", "FAM3C", "FAM49B", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXO22", "FBXO7", "FDFT1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP4", "FKBP8", "FKRP", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FNBP1", "FNBP4", "FNDC3A", "FNTA", "FNTB", "FOXK1", "FOXK2", "FOXRED1", "FRG1", "FSCN1", "FTL", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FUNDC2", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLC", "GCN1", "GDAP1", "GDE1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GGA2", "GGCX", "GGH", "GHDC", "GHITM", "GID4", "GIGYF2", "GINS1", "GINS2", "GINS3", "GINS4", "GIPC1", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAO1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLPH3", "GOLT1B", "GORASP2", "GOSR1", "GOSR2", "GOT2", "GPAT4", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR89B", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSR", "GSTK1", "GSTM2", "GSTM3", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2H4", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD2", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAT1", "HAUS1", "HAUS2", "HAUS4", "HAUS5", "HAX1", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HELLS", "HELZ", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCR", "HMGN1", "HMGXB4", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HP1BP3", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IFT88", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKG", "ILF2", "ILF3", "ILVBL", "IMMT", "IMP3", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INCENP", "INF2", "INPP4A", "INTS1", "INTS10", "INTS11", "INTS12", "INTS14", "INTS3", "INTS8", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "ISCU", "ISOC1", "IST1", "ITGAV", "ITGB1", "ITPRIP", "IVD", "JAGN1", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1468", "KIF11", "KIF14", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC4", "KNOP1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDAH", "LDB1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC59", "LRRC8C", "LRWD1", "LSM2", "LSM4", "LSM6", "LSS", "LTA4H", "LTV1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LYPLA2", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MAN1A1", "MAN1A2", "MAN2A1", "MANF", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4", "MAP7D1", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARK2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED16", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METTL1", "METTL13", "METTL3", "MFAP1", "MFF", "MFN2", "MFSD10", "MFSD8", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIEF1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMGT1", "MMS19", "MOGS", "MORC2", "MORF4L1", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPP1", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL27", "MRPL3", "MRPL33", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS17", "MRPS2", "MRPS21", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTOR", "MTPAP", "MTPN", "MTX1", "MTX2", "MUT", "MVD", "MXRA7", "MYBBP1A", "MYCBP", "MYCBP2", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAF1", "NAGLU", "NAMPT", "NAP1L1", "NAP1L4", "NAPA", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCDN", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCOR1", "NCSTN", "ND5", "NDC1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB11", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS5", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFB", "NELFCD", "NELFE", "NENF", "NES", "NF1", "NFRKB", "NFS1", "NFXL1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP2", "NISCH", "NKRF", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP10", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPC2", "NPHP3", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRM", "NRP1", "NSA2", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NT5C3A", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDCD3", "NUDT1", "NUDT19", "NUDT21", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OMA1", "OPA1", "OPA3", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTULIN", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAK1IP1", "PAK2", "PAK4", "PALLD", "PARK7", "PARL", "PARN", "PARP1", "PARP2", "PBRM1", "PBXIP1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCM1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDS5A", "PDS5B", "PDSS2", "PDXDC1", "PDXK", "PECR", "PEF1", "PELP1", "PES1", "PEX1", "PEX14", "PEX19", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGK1", "PGM1", "PGM2", "PGRMC1", "PHAX", "PHB", "PHB2", "PHC2", "PHF10", "PHF5A", "PHF6", "PHIP", "PHPT1", "PI4K2A", "PI4KA", "PICALM", "PIGG", "PIGK", "PIGS", "PIGT", "PIH1D1", "PIK3C2A", "PIK3R2", "PIN4", "PINX1", "PIP4K2C", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PMPCA", "PMPCB", "PMVK", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLE4", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR2L", "POLR3A", "POLR3C", "POLR3E", "POLRMT", "PON2", "POP1", "POR", "PPA2", "PPAN", "PPFIA1", "PPHLN1", "PPIB", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPM1F", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R9B", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRELID3B", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2C", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSMG1", "PSPC1", "PSPH", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTK7", "PTPA", "PTPN1", "PTPRF", "PTRH2", "PUM1", "PUM3", "PURA", "PUS1", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RABAC1", "RABEP1", "RABGAP1", "RABGEF1", "RABGGTA", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANGAP1", "RAP1GDS1", "RAP2B", "RAPGEF2", "RARS", "RASA1", "RBBP5", "RBBP6", "RBFA", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM7", "RBM8A", "RBMX", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REPS1", "RER1", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT2", "RIDA", "RIF1", "RINT1", "RIOK2", "RIPK1", "RMDN1", "RMDN3", "RMND1", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF219", "RNF40", "RNMT", "RNPS1", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPA3", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS27", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCB", "RTF1", "RTFDC1", "RTN1", "RTN2", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS2", "SART1", "SART3", "SBDS", "SC5D", "SCAF1", "SCAF11", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCAP", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCRIB", "SCRN1", "SCYL2", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHCBP1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIN3A", "SIN3B", "SIRT1", "SIRT2", "SKA3", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC2A8", "SLC30A5", "SLC30A9", "SLC35A4", "SLC35B2", "SLC38A1", "SLC39A14", "SLC3A2", "SLC44A1", "SLC4A7", "SLC7A1", "SLC9A3R1", "SLFN11", "SLIRP", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNIP1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX2", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPDL1", "SPECC1L", "SPEN", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRFBP1", "SRI", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR3", "SSR4", "SSRP1", "ST3GAL4", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK26", "STK4", "STMN1", "STOML2", "STRAP", "STRBP", "STRN", "STT3A", "STT3B", "STUB1", "STX10", "STX12", "STX18", "STX4", "STX5", "STX6", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUMF2", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE1", "SYNE2", "SYNGR2", "SYNJ2BP", "TAB1", "TACC3", "TAF15", "TAF6L", "TARDBP", "TARS2", "TBC1D10A", "TBCA", "TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDP2", "TECR", "TEFM", "TELO2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFRC", "TGOLN2", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM13", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMMDC1", "TJP1", "TJP2", "TKT", "TLN1", "TLN2", "TM9SF2", "TM9SF4", "TMA16", "TMBIM6", "TMCO1", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM126B", "TMEM14C", "TMEM192", "TMEM201", "TMEM214", "TMEM230", "TMEM33", "TMEM43", "TMEM65", "TMEM70", "TMEM87A", "TMEM97", "TMF1", "TMLHE", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX4", "TNKS1BP1", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM6", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1A", "TOR1AIP1", "TOR1AIP2", "TOR1B", "TP53", "TP53BP1", "TPBG", "TPD52", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC2L", "TRAPPC3", "TRAPPC5", "TRAPPC8", "TRIM13", "TRIM21", "TRIM25", "TRIM28", "TRIO", "TRIP10", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSC2", "TSFM", "TSG101", "TSNAX", "TSPAN3", "TSPAN6", "TSPO", "TSPYL1", "TSR1", "TTC1", "TTC19", "TTC26", "TTC37", "TTF2", "TTK", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBG1", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TWNK", "TXLNG", "TXNDC12", "TXNDC5", "TXNDC9", "TXNL1", "TXNL4A", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "UBA1", "UBA2", "UBA5", "UBAC1", "UBAP2", "UBAP2L", "UBE2G2", "UBE2K", "UBE2L3", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBLCP1", "UBP1", "UBQLN2", "UBQLN4", "UBR4", "UBR5", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UFD1", "UFL1", "UFSP2", "UGGT1", "UHRF1", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF3B", "UQCC1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP28", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VEZT", "VIM", "VIRMA", "VKORC1L1", "VMP1", "VPS13A", "VPS13C", "VPS16", "VPS18", "VPS25", "VPS26A", "VPS26B", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS2", "WBP11", "WBP2", "WDR1", "WDR12", "WDR18", "WDR26", "WDR3", "WDR36", "WDR4", "WDR41", "WDR43", "WDR46", "WDR5", "WDR61", "WDR70", "WDR73", "WDR74", "WDR75", "WDR76", "WDR77", "WDR82", "WFS1", "WIPI2", "WIZ", "WRAP53", "WTAP", "XAB2", "XPA", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YIF1A", "YIF1B", "YIPF4", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDF2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H14", "ZC3H18", "ZC3HC1", "ZCCHC8", "ZDHHC6", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZNF207", "ZNF326", "ZNF638", "ZPR1", "ZW10", "ZWILCH", "ZYX", "ZZZ3"], "leading_proteins": ["AAAS", "ABCB1", "ABCB7", "ACADVL", "ACOX1", "ACP2", "ACTL6A", "ACTN1", "ACTN4", "ADA", "ADPGK", "AFG3L2", "AGK", "AGPAT5", "AGPS", "AHSA1", "AIFM1", "AKT2", "ALDH3A2", "ALG1", "ALG12", "ALG9", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANKLE2", "ANKRD13A", "ANO6", "ANXA7", "APC", "APOO", "APOOL", "ARFGAP1", "ARFIP1", "ARID1A", "ARL6IP1", "ARL6IP5", "ARMCX3", "ASAH1", "ASNA1", "ATAD3A", "ATAD3B", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5B", "ATP5F1", "ATP5H", "ATP5I", "ATP5L", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V1E1", "ATP7A", "ATP7B", "AUP1", "B3GALT6", "B4GAT1", "BAIAP2", "BCAP31", "BCL2L13", "BCS1L", "BICD2", "BLOC1S1", "BNIP1", "BRAP", "BSG", "BUB1B", "C12orf43", "C12orf73", "C19orf70", "CALU", "CANX", "CCDC22", "CCDC47", "CD276", "CD47", "CDC27", "CDK5RAP2", "CDKAL1", "CDS2", "CETN2", "CHCHD3", "CHMP1A", "CHMP2B", "CHMP3", "CHST14", "CISD1", "CKAP4", "CLCN3", "CLN5", "CLPTM1", "CLTA", "CNNM4", "CNP", "COA3", "COG3", "COG7", "COLEC12", "COMMD1", "COPS4", "COPS8", "COQ8A", "COX11", "COX14", "COX15", "COX2", "COX4I1", "COX5A", "COX6C", "COX7A2", "CPSF1", "CPSF2", "CPSF3", "CPSF7", "CPT1A", "CPT2", "CRK", "CRTAP", "CSTF1", "CSTF2", "CTNNB1", "CTSA", "CXADR", "CYB5B", "CYB5R3", "CYP51A1", "DAG1", "DAGLB", "DCTN3", "DDRGK1", "DERL1", "DHCR24", "DHODH", "DHRS7", "DHX33", "DIABLO", "DLD", "DLG1", "DNAJC1", "DNAJC11", "DNAJC3", "DOLPP1", "DPF2", "DR1", "DYM", "ECE1", "ECH1", "ECSIT", "EEA1", "EHD1", "EHD4", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EPB41L2", "EPDR1", "EPHA7", "EPHX1", "ERAP1", "ERC1", "ERGIC1", "ERGIC3", "ERLIN1", "ERLIN2", "ERO1A", "ESYT2", "ETFDH", "EXOC7", "FAF2", "FAM162A", "FAM3C", "FDFT1", "FECH", "FIP1L1", "FKBP14", "FKRP", "FLOT1", "FOXRED1", "FTL", "FUCA1", "FUCA2", "FUNDC2", "GAA", "GALNT1", "GALNT2", "GBA", "GDAP1", "GDE1", "GGCX", "GGH", "GHDC", "GHITM", "GINS2", "GLA", "GLB1", "GLG1", "GM2A", "GNA13", "GNAI1", "GNAI2", "GNAO1", "GNS", "GOLGA5", "GOLGB1", "GOLPH3", "GOLT1B", "GOSR1", "GPR107", "GPR89B", "GPX8", "GRB2", "GSK3A", "GTF2E1", "GUSB", "H2AFX", "HACD3", "HAUS4", "HAUS5", "HEXA", "HGS", "HK2", "HLA-A", "HLA-B", "HLA-C", "HM13", "HMGCR", "HMOX1", "HMOX2", "HNRNPAB", "HPS6", "HS2ST1", "HSD17B12", "HSDL1", "HSP90B1", "HSPA13", "HTRA2", "ICMT", "IFT88", "IGF2R", "IKBIP", "ILF2", "ILVBL", "IMMT", "IMPAD1", "INA", "INPP4A", "ITGB1", "JAGN1", "KDELR1", "KDSR", "KIAA0319L", "KPNA2", "L2HGDH", "LAMP1", "LAMP2", "LAMTOR1", "LBR", "LDAH", "LEMD2", "LEMD3", "LETM1", "LGALS3BP", "LIPA", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LPCAT1", "LRRC59", "LRRC8C", "LSS", "LTA4H", "M6PR", "MAGT1", "MAN1A2", "MAN2A1", "MAPK1", "MAPK3", "MBOAT7", "MCL1", "MCM6", "MCU", "MFF", "MFN2", "MFSD10", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIPEP", "MMGT1", "MOSPD2", "MPP2", "MPV17L2", "MRPL10", "MRPS9", "MSMO1", "MSN", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTX1", "MTX2", "MXRA7", "NAGLU", "NAP1L1", "NBN", "NCDN", "NCLN", "NCSTN", "NDC1", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFB10", "NDUFB11", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS2", "NEFL", "NEFM", "NENF", "NES", "NNT", "NPC1", "NRM", "NSDHL", "NSUN2", "NUCB1", "NUCB2", "NUDT1", "NUDT21", "NUP35", "NUP37", "NUP54", "NUP93", "NUP98", "NXF1", "OCIAD1", "OCLN", "OMA1", "OPA1", "OSBPL11", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HB", "PABPN1", "PARL", "PCM1", "PCYOX1", "PDE6D", "PECR", "PEF1", "PEX14", "PEX19", "PFDN2", "PFDN6", "PGRMC1", "PHB", "PHB2", "PHC2", "PI4K2A", "PIGG", "PIGK", "PIGS", "PIGT", "PIH1D1", "PIK3R2", "PISD", "PKMYT1", "PLA2G15", "PLBD2", "PLD3", "PLD6", "PLK1", "PLXNB2", "PMPCA", "PON2", "POR", "PPHLN1", "PPT1", "PPT2", "PRAF2", "PRCP", "PREPL", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRRC1", "PSMB5", "PSPC1", "PTDSS2", "PTGES2", "PTPN1", "PTPRF", "PXMP2", "QSOX2", "RAB10", "RAB11B", "RAB14", "RAB1A", "RAB1B", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB4A", "RAB5A", "RAB5B", "RAB7A", "RABAC1", "RANBP2", "RCN2", "RDH13", "REEP4", "REEP5", "RER1", "RETSAT", "RINT1", "RIPK1", "RMDN3", "RNASET2", "RNF2", "RNF20", "RNF40", "RPN1", "RTN1", "RTN2", "RTN3", "RTN4", "SACM1L", "SAMM50", "SAR1A", "SC5D", "SCAMP1", "SCAMP2", "SCAMP3", "SCAP", "SCARB1", "SCARB2", "SCCPDH", "SCO1", "SCO2", "SCRIB", 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setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Cation transmembrane transporter activity 50 75 4.488705236941977 7.1657366915722776e-06 25.62135922330097 70.51699029126213 1.766742880952279 0.2698419237572138 12.29126021871486 8.422243011776631 2.00238274385689 0.3706372466673562 6.709218876754654e-09 0.0044283052837329 7.179090621618829e-05 1.173309482010712e-05 5.72440703832187e-09 +Inorganic molecular entity transmembrane transporter activity 43 76 4.319025978654965 1.56719335397959e-05 28.058252427184467 75.9635922330097 1.5031303400189615 0.2894264293069549 11.721339963426631 9.38477049228959 2.153051736566399 0.3821536813265525 2.197520772816465e-08 1.5354000481265248e-05 5.170100471610237e-07 1.62813553275723e-06 6.06173899188221e-09 +Ion transmembrane transporter activity 62 105 4.161970183598656 3.155135555910071e-05 37.34466019417476 101.497572815534 2.0154097423383375 0.2561362875319209 17.172953606300336 11.579295798802024 2.277787478419462 0.3756175790939143 5.336573249996442e-12 1.1664139678007732e-05 2.3398225097489645e-07 1.1322001618475633e-07 2.019489379913516e-12 +Active transmembrane transporter activity 40 72 3.811351603089398 0.0001382090167172 26.354368932038835 73.12621359223301 1.313035419122872 0.3239574057550545 11.878456281473593 8.663537710607383 1.88741562841277 0.3851687956916088 1.1807310727583236e-06 0.2459530387672467 0.0130891925218009 0.0003790032620182 1.5453346215075963e-06 +Proton transmembrane transporter activity 13 35 3.7977409986333504 0.0001460207813204 12.769417475728156 35.478155339805824 1.2352045534927034 0.2879171268332734 5.319202861157036 2.7149368379617917 1.7021108079122016 0.3308025072902738 8.659516749167009e-07 0.0003907011914147 4.880703433481206e-07 1.409154043015818e-06 2.0440750709764312e-06 +Anion transmembrane transporter activity 33 46 3.765327883816529 0.0001663306679609 18.594660194174757 45.61893203883495 1.6222323024349488 0.2373683627198559 9.346785472607134 6.017202751823004 1.8117646078257517 0.3183345645365742 0.0001184247385207 0.0028425109062126 0.001316320715177 0.0111927939680839 0.0001193187987068 +Organic anion transmembrane transporter activity 22 31 3.728440223123005 0.0001926685970519 12.951456310679612 30.182038834951456 1.56101282472555 0.2452312368187786 6.880574373146614 3.5222410835885483 1.575669523214114 0.314839840161206 0.0059393768764808 0.3315322885250054 0.0483217377147592 0.0543296939149059 0.0078989663196461 +Primary active transmembrane transporter activity 21 52 3.66024560204486 0.0002519736135917 17.696601941747574 52.529126213592235 1.0080198242353189 0.3544097082146772 7.649017203625277 6.455721193615876 1.66885648871365 0.3767837436492733 3.6949256805661255e-08 0.109317488334835 0.005908972667517 6.0531558633589976e-06 5.8196789450259134e-08 +Active ion transmembrane transporter activity 27 42 3.653752496599195 0.0002584353983157 16.271844660194176 41.71116504854369 1.2957221273899948 0.3267733012969381 7.788084220174416 5.097264791179653 1.6571109350293016 0.3632481416270505 5.541280951520037e-05 0.1063034743231946 0.0267992171546872 0.0076750055009357 5.169265078828557e-05 +Steroid binding 12 21 3.524251803822656 0.0004246804641412 8.424757281553399 21.398058252427184 1.4469817519716153 0.1523451695819165 3.035656818503787 2.066091501771892 1.85140774519605 0.2395996334984524 2.7875596956182285e-07 7.841716015047822e-05 0.0012207780133745 0.0001580597168237 3.742420073846254e-07 +Transporter activity 82 167 3.4746798010393367 0.0005114634678247 62.22330097087379 172.27912621359224 2.173366592838491 0.2707201784543502 25.984753572620328 19.29276868436311 2.593156143256053 0.3916539604106395 9.4353123106356e-17 2.1672315664888277e-05 7.905652984158376e-08 1.7596690418948628e-10 1.9013566874607644e-16 +Tetrapyrrole binding 7 15 3.371652836793088 0.0007471856807772 7.402912621359223 16.83252427184466 2.0044897428967667 0.1259264696495541 2.9589081005845346 2.0417036568087963 1.3464702305086589 0.2177422235164347 0.001116781538703 0.0020524288782531 0.0149914480702132 0.0002941476334404 0.0042301612836837 +Molecular transducer activity 18 32 3.2095885864236338 0.0013292507949751 10.91747572815534 33.40533980582524 1.343848990749489 0.2329582295822712 4.7124072380860955 5.830391636254363 1.6098335072319665 0.2956883791113679 0.4325919422003392 0.3437849543692213 0.7139346274642253 0.4305997721280159 0.4860925960432058 +Metal ion transmembrane transporter activity 18 28 3.132893089457481 0.0017309247743031 9.563106796116504 24.67233009708738 0.8657396859235934 0.3700615753207195 4.93288923178502 4.839352380624028 1.4450904591933955 0.3424002804304004 0.0029731534934931 0.4396258949303272 0.6943670866160305 0.172108822769145 0.0008079841825705 +Organic acid transmembrane transporter activity 13 20 3.0759910414695257 0.0020980414864284 8.592233009708737 21.276699029126213 1.5973629153049684 0.1905568538747131 4.4420473133518055 2.549726956007885 1.3213968531498468 0.2647933566957936 0.0499393888632567 0.2752604452820565 0.0275216398495969 0.0814773755217055 0.0460574281433519 +Alcohol binding 7 16 3.04486936220377 0.0023278139815621 5.70873786407767 16.094660194174757 1.0972550148478282 0.1642412137618775 2.3364194162363723 2.1334758164294443 1.72577974721897 0.2306417307890987 0.003153898856655 8.49425410120894e-05 0.0013172485850202 0.0068683859678987 0.0025854516113679 +Atpase coupled transmembrane transporter activity 11 20 3.014985212206726 0.0025699178524121 8.072815533980583 22.696601941747577 0.8561067713091313 0.3392846662603397 4.166386392056555 3.892074110340729 1.3163009809214623 0.3229730128136945 7.44981635966043e-05 1.0 1.0 0.0127222619547071 1.7329168891142377e-05 +Oxidoreduction driven active transmembrane transporter activity 9 32 2.9885087860006845 0.002803424399729 9.733009708737864 29.83252427184466 0.7626445826297276 0.3795490924215395 4.629116134249794 3.4519743101246267 1.4198222355288384 0.35536187545778 0.0001334678892395 0.0343104139968933 0.0003105660221664 0.0001124126246146 0.0007324740008612 +Secondary active transmembrane transporter activity 14 20 2.9829689906347463 0.0028546691538844 9.080097087378642 21.490291262135923 1.2627683473613005 0.2947710034053126 5.466215032972134 3.0675886156990426 1.4241587428281404 0.3340388164945335 0.4554031872303045 1.0 0.5741114914523541 0.8845080783320115 0.4256782528579432 +Sterol binding 8 17 2.9652665540843133 0.0030242077130586 5.495145631067961 16.27912621359223 1.1610523788441311 0.1592175050218891 2.159304933149918 1.9111962434971217 1.7231989277496158 0.231586711794193 6.019238934400498e-05 2.280160421415856e-05 0.0003733671894444 0.0016056440309417 4.047721243423012e-05 +Passive transmembrane transporter activity 17 32 2.938856116001749 0.0032942596690417 10.728155339805824 34.00242718446602 0.8598494327527568 0.3171523987434088 5.464704354730218 4.259483301090722 1.5882390061019254 0.3339692919660049 0.0139601182687094 0.0001867313029992 0.0007816352528268 0.0575259106236958 0.0091850044185398 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 10 29 2.924686672318364 0.0034480320560288 9.395631067961164 29.8373786407767 1.5709767518568172 0.2393367467664754 3.119976403291062 3.762391942431812 1.2135099906711824 0.3124947384976632 0.0034137263336624 0.0708561744170628 0.2248900268904883 0.0071204993039649 0.0052453150917069 +Cholesterol binding 7 13 2.879325820276068 0.0039852637041957 5.25 13.29126213592233 1.1679703080780182 0.1357521674166823 1.9454015982929531 1.7674569958716484 1.7544522374432017 0.2116991383290636 0.0001262034867044 1.0830323879735215e-05 0.0001815434943904 0.0006827439557333 6.616615234342882e-05 +Protein transporter activity 9 13 2.876618669475965 0.004019610225642 6.053398058252427 14.696601941747574 1.6882240898296943 0.1359359142649309 2.957968193176 1.443999336657768 1.4805047019217734 0.2345897542974644 3.531825849574383e-05 0.0060764540616979 0.0016986126979642 2.2359581100408143e-05 1.4175664763662648e-06 +Hydrolase activity hydrolyzing o glycosyl compounds 11 20 2.8573596193576747 0.0042718154673959 8.830097087378642 20.84223300970874 0.5983257656540719 0.2104301479001341 3.2223833352824554 2.4557961681485057 1.9540573665272416 0.2728112677124137 1.7999599304431238e-06 1.0 0.371655018795122 0.0009743779436676 2.1096695340192896e-06 +Monooxygenase activity 5 9 2.793269117971348 0.0052178262258557 4.043689320388349 8.322815533980583 1.6049222537693364 0.1501440468766332 1.612461779657682 1.2307404965531048 1.237349324058907 0.2369071661653372 0.0005152852106469 0.0070670490819082 0.0274603336438859 3.588913913812074e-05 0.0015706126808535 +Hydrolase activity acting on glycosyl bonds 12 27 2.784269473921752 0.0053648441821516 10.133495145631068 28.40776699029126 0.6089784953463463 0.2409908190925149 3.36301188653944 3.2424277527979313 1.935823411407979 0.3010513017078077 2.3678435972380104e-05 1.0 0.1554832015057707 0.0018365459096632 4.220262440537482e-05 +Serine hydrolase activity 8 18 2.777382291106904 0.0054798684418442 6.934466019417476 18.83009708737864 1.2767207242593377 0.1489147276149277 2.386872767465543 1.965791668457755 1.709796217367629 0.2208345231085202 0.0024861818192233 0.0213334360876883 9.137815410524424e-05 0.0057706709278987 0.0004290006789134 +Sphingolipid binding 5 6 2.7109170681320856 0.0067097405871754 3.2305825242718447 6.810679611650485 1.3881601090528384 0.1287371848492678 1.3662849673921555 1.293404675510669 1.5116584105270494 0.2146285912590262 4.362323210659826e-05 0.0031646532309382 0.0006327439593496 2.7013551728451183e-06 0.0001429815632908 +Metalloendopeptidase activity 5 15 2.684296090577555 0.007268270496237 5.449029126213592 14.364077669902912 1.4597326207035937 0.2246869419023046 2.4848715129851016 0.6671711573432166 0.9390012824303952 0.2775881383017788 0.0015802568545913 1.0 0.0038117145357013 0.0010720436073174 0.0045924061823516 +Lipase activity 8 19 2.658595023666773 0.0078467219546667 4.160194174757281 17.95145631067961 -0.3883889220249866 0.2447386375427953 2.2541370727794456 2.684470408535888 1.602380040893784 0.2433104127648577 0.0020072330316649 1.0 0.1100932826860655 0.000511542389694 0.0020026076269409 +Oxidoreductase activity acting on a heme group of donors 4 7 2.64920631866534 0.0080681060335703 3.111650485436894 6.483009708737864 0.8850005512180296 0.2757097651603665 1.538237610319269 1.0226572421183926 1.2777814224392188 0.2966482201944345 0.0001964363060589 0.0683810764565047 0.0003602808960722 0.000366006536683 0.0005289198821125 +Macromolecule transmembrane transporter activity 7 11 2.635386128843056 0.0084041619002241 4.820388349514563 12.281553398058252 1.6605285757306012 0.1306403746261988 2.4754663863133306 1.0160601209961664 1.3599823000893485 0.2280235038874096 8.519227121397021e-05 0.0039064712270754 0.0008717411361388 9.045491853019026e-05 2.7180346417726147e-05 +Nucleobase containing compound transmembrane transporter activity 9 12 2.598801851920228 0.0093549756071202 6.529126213592233 14.04126213592233 1.4296604886183193 0.212054291115069 3.2696940585469636 1.915888183904924 1.3255809572534116 0.2748813593420038 0.0076104440684934 0.1403531442218371 0.266209970857853 0.1800390494619342 0.0179733508374719 +Transition metal ion transmembrane transporter activity 6 7 2.589653844269149 0.0096072483852265 2.2597087378640777 4.444174757281553 1.267846808399692 0.205487024774009 1.5353529408674886 1.9618423203326616 1.2931295194130703 0.2516620757205828 2.630958324992287e-05 0.1071891284628969 0.2070995190727305 0.0193169154759243 0.0001024209024739 +Protein transmembrane transporter activity 7 10 2.573630635057267 0.0100637647033889 4.37621359223301 11.264563106796116 1.6409152716253632 0.1284874270119089 2.3258190399954897 0.995332092405782 1.387057072324357 0.2266762256512647 3.007161845311034e-05 0.0028214739728005 0.0005309775927247 3.830880641039723e-05 7.746328029618005e-06 +Ceramide binding 4 5 2.5636633280325505 0.0103573957043761 2.8228155339805827 5.048543689320389 1.42330045764979 0.1242195400491618 1.17628831869178 0.9309003969609838 1.481980135982154 0.2133994029014766 8.985506357909055e-05 0.0016377422378922 0.0002296483500821 8.624555272386569e-06 0.0002457979454447 +Electron transfer activity 13 55 2.55468445083657 0.0106284100918994 14.919902912621358 52.12621359223301 0.5312195787834075 0.4459804256520286 6.65997259318913 4.498499451328372 1.405540355221493 0.3721784721862224 0.0001370059633956 0.0115064399742295 0.0003891202112714 0.0001434833065057 0.0003176274883727 +Lipid transporter activity 5 17 2.536718234525085 0.0111896975033658 6.546116504854369 19.805825242718445 0.7389006587243017 0.301332987440896 3.074370954053146 3.741159812966952 1.4134673193588587 0.2984913911167897 0.0811954190955097 1.0 0.5259644699110895 0.1150876300860403 0.1700618733952761 +Serine type exopeptidase activity 4 7 2.490273419406402 0.012764485561528 3.783980582524272 6.997572815533981 1.020609253431403 0.1137432544246352 1.3363606860118669 0.0492066381861973 1.87035730934538 0.1990592265121372 1.0025096548661049e-05 0.0007650215967213 9.047098753082273e-09 9.14133433735114e-07 9.4206715064497e-07 +Nucleotide transmembrane transporter activity 8 10 2.4791036476511628 0.0131713025587885 5.606796116504855 12.029126213592232 1.4217258291760082 0.2036087501116975 3.0234925518113496 1.8899648667798992 1.291115513359647 0.2666064512499804 0.00821576936754 0.0944323477659319 0.1837383274168749 0.0901924811619011 0.017002584405276 +Organophosphate ester transmembrane transporter activity 8 10 2.4791036476511628 0.0131713025587885 5.665048543689321 12.143203883495143 1.4298365636921646 0.2056324024803549 3.029697948284232 1.927415248708952 1.2819429632405106 0.2680490563295835 0.0097364536063123 0.0987043131013681 0.191600110602388 0.097689242801984 0.0200033311952484 +Snap receptor activity 10 16 2.472600072837368 0.0134134153621232 5.803398058252427 13.6626213592233 0.8920027438628428 0.3386294703372389 3.103034547770364 2.9171839264116786 1.2201519782198902 0.3219991979242683 0.0018564811497816 0.1484538203623246 0.0041517217414646 0.0001415457384854 0.0010440793255692 +P type transmembrane transporter activity 6 8 2.460033923486041 0.0138923883672774 2.842233009708738 5.473300970873787 0.6050493013674468 0.3730987003611934 1.6045635356324264 1.3712604140019378 1.17652933932801 0.3174788438558891 2.654908181424621e-06 1.0 1.0 0.032628233248221 3.903860956515125e-07 +Exogenous protein binding 6 16 2.4330586406700534 0.0149718759165773 4.509708737864078 15.157766990291265 0.7214109752050332 0.2527966464979699 2.499010078306418 1.9009100692398744 1.5211756979359785 0.2791170769282048 0.0016947901282419 0.1916891885455893 0.3530974878629287 0.0227330174276438 0.0055591316089767 +Hexosyltransferase activity 8 31 2.422387966780566 0.0154188792915879 9.633495145631068 33.87864077669903 0.7349501031127185 0.3949358882560483 4.261380470236419 4.330948695045228 1.2646745007039175 0.3422146027467064 0.0349705978388104 1.0 0.6695171460893661 0.5218778121271003 0.0500599336441153 +Exopeptidase activity 13 32 2.420308529567357 0.0155073435330908 9.74514563106796 31.84223300970874 1.193034763402526 0.2308543476384821 3.0338864063053523 1.9513159274241312 1.6646797512653713 0.2911825093455628 0.0001159230439185 0.0333019544595367 2.4490692503129386e-05 9.996092046331004e-05 5.478593541938059e-06 +Acid phosphatase activity 1 5 2.416155524618346 0.0156853600785689 0.9878640776699028 3.966019417475728 0.9052826988610366 0.3068796361114562 0.851810351386389 0.6959038821670667 1.079620052215366 0.2579051902417928 0.0282844660019362 0.0004489552138259 0.0018609890552042 0.0112385866308786 0.0419919493306108 +Inorganic anion transmembrane transporter activity 11 18 2.3894999335891915 0.0168713269121418 7.427184466019417 19.274271844660195 1.0921593405593897 0.2441056926448881 3.717191605498929 3.7816647851785734 1.4014196343960104 0.2816216967014333 0.0039505840593066 0.0018407641855875 0.0015259573241502 0.0362911702166911 0.0033296386804888 +Serine type carboxypeptidase activity 3 5 2.386859515116223 0.0169929834136064 3.0558252427184467 4.997572815533981 1.0019911760482532 0.1105835516254352 1.1231414198895626 0.0492066381861973 1.8086551291944464 0.1930654928989846 1.1310954225869592e-05 0.0233225886554715 3.9836639152197847e-08 1.6228361660218084e-06 2.6454681464607386e-07 +Vitamin transmembrane transporter activity 5 7 2.3597366307935994 0.0182879133296072 2.7766990291262137 6.252427184466019 1.4438342367310928 0.182339474606115 1.52603324115363 1.3650879028699858 1.0282691527982806 0.2346378729908682 0.0006679426562608 0.0858288536093336 0.1677870330809631 0.0757571260003459 0.0017429018144962 +Carbohydrate derivative transmembrane transporter activity 7 9 2.356169019437619 0.0184645141380099 4.672330097087379 10.12135922330097 1.0096229459917263 0.2944050311743799 2.686158589641687 1.471354338494036 1.2935479322863277 0.3146313980204608 0.0800372925933584 1.0 1.0 0.4704807306772423 0.1298078118605267 +Atpase coupled cation transmembrane transporter activity 8 16 2.3328904787682454 0.0196538942267421 4.798543689320389 14.434466019417476 0.5910750448608943 0.4613904105338446 2.543924385121825 1.7948352160376215 0.9540113823486516 0.3207668712362007 0.0001000965810775 1.0 1.0 0.0319451393300601 5.837517180193655e-06 +Antiporter activity 8 9 2.3033436902192275 0.0212595132711885 4.621359223300971 10.405339805825244 1.056576117278179 0.2813324268221227 2.679901841610502 1.304685592846984 1.2558310293487471 0.3063102364368053 0.1960220595570524 1.0 0.3143397790261298 0.6149168035506691 0.2936288791787133 +Palmitoyltransferase activity 3 6 2.2845320857605023 0.0223402791220399 1.8786407766990292 5.084951456310679 0.875863834441912 0.3421870647647222 1.2306088543936362 0.6827036113457149 1.018188317250868 0.2997914787323893 0.0056600728487245 1.0 1.0 0.0757571260003459 0.0118865434534573 +Proton channel activity 4 11 2.2840791282870536 0.0223668809750063 3.655339805825242 10.75485436893204 0.46898650441807 0.3141755537304957 2.268964442606705 0.8649601417133376 1.3429609354721883 0.2856466957651606 0.0036978306683598 0.0028214739728005 0.0005309775927247 0.0073447144383531 0.0010053263520343 +Proton transporting atp synthase activity rotational mechanism 4 11 2.2840791282870536 0.0223668809750063 3.655339805825242 10.75485436893204 0.46898650441807 0.3141755537304957 2.268964442606705 0.8649601417133376 1.3429609354721883 0.2856466957651606 0.002916997936102 0.0024970154667983 0.000440337804097 0.0061570039439817 0.0007388687073799 +Cation channel activity 7 21 2.283105400648248 0.0224241605230097 6.628640776699029 20.20145631067961 0.2168681550185727 0.4203796109119975 3.66569707500714 2.3934980322982335 1.245793992642405 0.316602380113191 0.0697863152348599 0.0473022522201117 0.034172513126223 0.2645177746775517 0.0264828345654996 +Endopeptidase activity 20 58 2.2661770174775167 0.0234405471966616 19.08495145631068 62.800970873786405 1.5604938505680932 0.2935756148549138 5.629332570724372 6.156865220927466 1.27979578418692 0.359984229645684 0.0135945903297815 0.5460422758388164 0.0756746726427118 0.019147656697531 0.0067701334559591 +Phosphatidylcholine binding 2 8 2.252869986827677 0.0242673477558694 2.2524271844660193 7.929611650485437 1.2697801287388335 0.1567893034984199 1.081337239384838 1.04388968498945 1.4953842980517238 0.2256102823610289 0.0229393586787355 5.253086721125362e-05 0.000440337804097 0.0061570039439817 0.0397387250697101 +Purine nucleotide transmembrane transporter activity 6 8 2.245777774990596 0.0247182455670915 4.334951456310679 9.441747572815531 0.9917737457277228 0.2833655940290197 2.4104227054611673 1.6217588601139772 1.262135146193827 0.3001583617421954 0.1284017178718295 1.0 1.0 0.3236592382947187 0.1807018090276839 +Cargo receptor activity 5 7 2.2276923660262646 0.0259010364381298 3.7063106796116503 7.95873786407767 0.9623237890522576 0.1578680760704802 1.9530058934839476 1.7914972745396005 1.6202205206532496 0.203966946010782 0.0226697205376047 0.1239247827595126 0.2372212797486779 0.0291459656321865 0.0446088038944012 +Dicarboxylic acid transmembrane transporter activity 7 8 2.200797669287297 0.0277503506751837 2.842233009708738 7.20873786407767 1.0708946030323223 0.2426579907451208 1.9772646753006824 0.7975212565102757 1.0844681659651012 0.2564515003952125 0.0229393586787355 1.0 0.1432798584585485 0.3236592382947187 0.0062633876942655 +Amino acid transmembrane transporter activity 7 10 2.1826371017903767 0.0290625452564865 4.325242718446602 10.521844660194176 0.9562493229862624 0.2921494362491497 2.574340086864074 1.34633933573134 1.106576767449958 0.2884960270895668 0.4691439799312159 1.0 0.3209553841799009 0.6242434222626774 0.307100773996071 +Collagen binding 5 8 2.178441329968767 0.0293731957153462 2.716019417475728 8.723300970873787 0.69823887636622 0.4150184287426759 1.4191600413356955 1.3333441338677146 0.9396547940704922 0.2968068810392446 0.0317940073744775 1.0 1.0 0.1713585638073601 0.0612536211646263 +Glycolipid binding 5 8 2.1397422997552087 0.032375598560798 3.95873786407767 9.17233009708738 1.1300394975336625 0.1723818604496332 1.779261971800237 1.789101691327159 1.517965150696512 0.2390589148665743 0.0003792915561059 0.0028214739728005 0.0005309775927247 3.830880641039723e-05 9.937036022358197e-05 +Syntaxin binding 5 18 2.132928787624855 0.0329305683958769 5.718446601941747 18.83495145631068 0.1087410478883906 0.6145321693967447 2.79360391424284 2.517307420266533 0.8508007201873308 0.3156154278232865 0.0486707268156107 1.0 0.3896854720293997 0.0341229578056568 0.0359869143678365 +Carboxypeptidase activity 5 12 2.128416875955032 0.0333025351605702 3.941747572815534 11.944174757281552 0.6619369631013473 0.2217581052142344 1.5253536449314826 0.7722681563953175 1.6063564059694095 0.2594343390807456 0.0132990521925985 0.1071891284628969 7.357256485958134e-05 0.0024022577840735 0.0008083265510004 +Mannosyltransferase activity 2 6 2.122714820786378 0.03377775630845 2.0509708737864076 5.347087378640777 0.3259733201852472 0.4146291728353291 1.31637337531163 1.1377956298376235 1.1111107346144888 0.2988315692108667 0.0315532322883059 1.0 1.0 0.3559534457378639 0.0539281835546241 +Phospholipid binding 14 83 2.1223303923641432 0.0338100029911137 18.890776699029125 88.4635922330097 0.777309720287493 0.452120200534915 6.970479526806733 10.51702894240924 1.1988133109990275 0.3785217149858343 0.2075970781460952 0.0133340434123436 0.0705024019636937 0.006471971429424 0.2154489737873231 +Sulfur compound transmembrane transporter activity 3 5 2.1162974557937684 0.0343195170024439 2.9635922330097086 6.752427184466019 1.4746434057995097 0.1672652154050841 1.7026919602194592 1.5538455059459366 1.0954441166028872 0.2266277553273111 0.0255063530370172 1.0 0.2445730022705269 0.0319451393300601 0.0498364179528963 +Voltage gated anion channel activity 5 6 2.110208079301072 0.0348404369329364 2.854368932038835 6.25 1.127126362633441 0.1649553590552043 1.5417035527207152 0.9966570336472054 1.4583344406160936 0.2334940994157564 0.0004059252135544 1.148254609278584e-05 9.839858993160587e-05 0.0014684283121974 0.0009118158302113 +O acyltransferase activity 4 12 2.103525584870849 0.035419851215922 4.711165048543689 12.395631067961164 0.9877600518928406 0.2684789023147002 2.6842893514436073 2.3496085895491885 1.2379749168209273 0.2720543739153138 0.0076104440684934 1.0 1.0 0.0069928111010265 0.0179733508374719 +Mhc class i protein binding 4 7 2.098705933334841 0.0358428313208898 2.7135922330097086 7.936893203883495 0.4997309801019018 0.4236810840517632 1.5643199175999352 0.8594975153459443 1.0647070901951394 0.3142832966160581 0.0006182072975801 1.0 1.0 0.2356930071839008 9.569573614901708e-05 +Atpase binding 12 28 2.049370515847681 0.0404258980637091 7.101941747572815 27.883495145631063 0.4324538219085727 0.5124445450748666 3.2760229435557595 2.201283698181438 0.9496598819558206 0.3233068270066163 0.0414942711948671 1.0 0.4672829604777532 0.0715305134437747 0.012915229181212 +Iron ion binding 10 21 2.033450482459387 0.04200703150784 6.524271844660194 22.196601941747577 0.9076096695164306 0.382669917893863 2.4429198675966717 3.289094676807881 0.9378690899634522 0.3126784916965753 0.0095406655710695 0.2507644527164699 0.1163398228410075 0.0155889061230085 0.008913025090531 +Prenyltransferase activity 3 7 2.0289603366707265 0.0424623303571993 2.099514563106796 6.009708737864078 0.6003375563696288 0.3888587975741492 1.4081247453019228 2.026499903013553 1.0962032128239394 0.3008779016140248 0.1152189229742136 1.0 1.0 0.0495157384890535 0.1630814235328921 +L amino acid transmembrane transporter activity 6 8 2.027880701519317 0.042572425214991 3.628640776699029 8.201456310679612 0.919975936290114 0.2876791162304417 2.2759730869054327 1.0290432051153906 1.15482978403653 0.2925518180165951 0.3157728908665094 1.0 0.2445730022705269 0.5079876539292768 0.1645088237572309 +Fad binding 7 10 2.022300555070966 0.0431453113298188 3.78883495145631 9.932038834951456 1.575439945642976 0.1698004033102896 1.8828741719818296 1.250336932628077 0.9196006746446306 0.2289411404885479 0.0175969319023928 1.0 1.0 0.4704807306772423 0.0074494564855197 +Metallopeptidase activity 11 41 2.0151238019892133 0.0438916788697838 11.548543689320388 40.60436893203884 1.2053444242445344 0.3510417366391842 4.586289489033314 2.1135899474190585 1.0988837346562612 0.3462572593421246 0.001091562086318 1.0 0.0415809882988902 0.0031061282245647 0.0004431313439272 +Mhc protein binding 4 8 2.009358294322898 0.0444991498114726 3.094660194174758 8.968446601941748 0.6294582460885748 0.3884738618046354 1.6140375204875843 0.8821171105149307 1.0893111588562217 0.3109068508502701 0.0017074381782845 1.0 1.0 0.2897526236095206 0.0003671727016274 +Phospholipase activity 4 16 2.0091115933997266 0.0445253004312438 3.1990291262135924 15.094660194174756 -0.306546996035562 0.2833880814714293 1.8628194074527815 2.042811367353886 1.4121024393654518 0.2371187700906001 0.0389735831554936 1.0 0.371655018795122 0.0057706709278987 0.0276636519393836 +Palmitoyl protein hydrolase activity 2 6 1.9846028985303852 0.0471886696118861 1.91747572815534 5.429611650485437 0.9780254626091984 0.222941388490727 1.137611804765983 0.8139540579221628 1.3123017012345466 0.2566673774233151 0.0101209673779209 0.0550816697898294 0.1094892401774078 0.0025975272437437 0.018020673376298 +Udp glycosyltransferase activity 3 13 1.9783836246252535 0.0478854456483293 5.111650485436893 16.645631067961165 0.3599735227181602 0.3819150449260511 2.50187506268716 3.5246228662547776 1.2344018614792536 0.2994506580113357 0.3394757987395312 1.0 0.5166489093314391 0.5437935802005475 0.4973319570282934 +Hexosaminidase activity 2 5 1.9776277315336264 0.0479707184405984 2.5194174757281553 4.973300970873787 0.3568105957806153 0.2227497456156347 1.091499214132507 0.3065083294438748 1.6445593916296413 0.2548912926080147 0.004218554219783 1.0 0.0832836732680532 0.0186627473263165 0.0076703518288617 diff --git a/msigdb_gomf/metrics.json b/msigdb_gomf/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..a480f1562f67855ad53625fe3ccbf6f6ae0cf5f5 --- /dev/null +++ b/msigdb_gomf/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3120, + "annotations_size": 1371, + "title": "Average number of proteins per term", + "value": 16.34281546316557 +} \ No newline at end of file diff --git a/msigdb_gomf/paths.json b/msigdb_gomf/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..93cba3056917bff1d580142693846a060c52e3f6 --- /dev/null +++ b/msigdb_gomf/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gomf/fragment/C390/C390_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gomf/result.tsv b/msigdb_gomf/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..855248cddfef13c56d1ea708a529bf296a66e30c --- /dev/null +++ b/msigdb_gomf/result.tsv @@ -0,0 +1,364 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Cation transmembrane transporter activity 0.6602663907729651 4.488705236941977 7.1657366915722776e-06 0.0097761598047658 0.0049121125020734 75 Q9H936,Q9Y487,Q9NW15,Q8N4V1,Q9H9B4,P20020,Q9UM00,Q04656,Q9UDW1,Q9HD20,P55011,O43808,Q7KZN9,O95202,O75964,Q8WWI5,P05026,P13073,O75947,O43772,P24539,P16615,P98194,P08195,Q70HW3,Q96NB2,P23634,Q8TAD4,P00846,Q9H0U3,P20674,P12235,P05023,P30825,P06576,Q15043,Q6P4Q7,P35670,Q93050,P05141,P56385,P00403,Q8NE86,P36543,Q13423,Q15758,Q9HC21,P51790,Q4KMQ2,Q9Y6M7 50 +Inorganic molecular entity transmembrane transporter activity 0.6429155688745901 4.319025978654965 1.56719335397959e-05 0.0212572011980911 0.0071620736276871 76 Q9NW15,Q9Y487,P0CG08,Q8N4V1,P20020,Q9UM00,Q04656,Q9UDW1,Q9HD20,Q9Y277,Q7KZN9,P21796,O95202,O75964,Q8TDW0,P05026,P13073,O75947,P16615,P24539,P98194,P45880,P23634,Q8TAD4,P00846,Q9H0U3,P20674,P12235,P05023,Q15043,P06576,Q6P4Q7,Q9UBX3,P35670,Q93050,P56385,P00403,Q8NE86,O43681,Q13423,P51790,Q4KMQ2,Q9Y6M7 43 +Ion transmembrane transporter activity 0.6585639491201039 4.161970183598656 3.155135555910071e-05 0.0423353274058356 0.0108142271178821 105 P41440,Q9Y487,P0CG08,Q9NW15,Q8N4V1,Q9H9B4,Q6NUK1,P20020,Q9H2D1,Q9UM00,Q04656,Q9UDW1,Q9Y277,Q9HD20,O43808,Q7KZN9,P21796,Q14728,O95202,O75964,Q8TDW0,P05026,P13073,O75947,P16615,P24539,P98194,O43772,P08195,Q70HW3,Q9BQT8,O75746,P45880,P23634,Q8TAD4,Q9UJS0,P00846,Q9NY64,Q9H0U3,Q9BVC6,P20674,P12235,Q8TB61,P05023,P30825,Q15043,P06576,Q6P4Q7,Q9UBX3,P35670,Q93050,P56385,P00403,Q8NE86,P12236,Q6P4A7,O43681,Q13423,Q9HC21,P51790,Q4KMQ2,Q9Y6M7 62 +Active transmembrane transporter activity 0.5845256424590943 3.811351603089398 0.0001382090167172 0.1726253448667052 0.025337705086044 72 P41440,Q9H936,O75027,P20020,Q04656,Q9P0J0,Q02978,Q9UDW1,Q9HD20,Q7KZN9,O95202,P05026,P13073,P16615,P98194,O95169,P08195,P23634,O96000,P08183,P20674,P12235,O75306,P05023,Q15043,P06576,Q9Y6M9,Q9UBX3,P35670,P05141,P00403,Q8NE86,Q15388,P12236,P36543,Q15758,O00483,P51790,O95168,Q9Y6M7 40 +Proton transmembrane transporter activity 0.6984313169162288 3.7977409986333504 0.0001460207813204 0.1814404329032037 0.025337705086044 35 P13073,Q9Y487,P20674,P24539,Q13423,Q9UDW1,P56385,Q7KZN9,P00403,O95202,Q93050,P00846,O75964 13 +Anion transmembrane transporter activity 0.6563304019102872 3.765327883816529 0.0001663306679609 0.203922163082353 0.025337705086044 46 Q9NW15,P41440,Q6NUK1,P0CG08,Q9H936,Q9H9B4,Q9H2D1,Q02978,Q9Y277,O43808,P21796,Q14728,Q8TDW0,P08195,Q9BQT8,O75746,P45880,Q96NB2,Q9UJS0,Q9NY64,P12235,Q8TB61,P30825,Q15043,Q9UBX3,P05141,P12236,O43681,Q15758,Q9HC21,P51790,Q4KMQ2,Q9Y6M7 33 +Organic anion transmembrane transporter activity 0.70706178541872 3.7284402231230054 0.0001926685970519 0.232160150135375 0.0264148646558176 31 Q9H936,P41440,Q6NUK1,Q9H9B4,Q9H2D1,O43808,Q14728,P08195,Q9BQT8,O75746,Q96NB2,Q9UJS0,Q9NY64,P12235,Q8TB61,P30825,Q9UBX3,P05141,P12236,Q15758,Q9HC21,Q9Y6M7 22 +Primary active transmembrane transporter activity 0.6186886593043222 3.660245602044859 0.0002519736135917 0.2921332112137251 0.0295262442575705 52 O75027,P20020,Q04656,Q9P0J0,Q9UDW1,Q9HD20,Q7KZN9,P13073,P16615,P98194,O95169,P23634,O96000,P08183,P20674,P05023,Q9Y6M9,P35670,P00403,Q15388,O95168 21 +Active ion transmembrane transporter activity 0.6570460007382365 3.653752496599195 0.0002584353983157 0.298378169247611 0.0295262442575705 42 P41440,Q9H936,P20020,Q04656,Q02978,Q9UDW1,Q9HD20,Q7KZN9,O95202,P05026,P13073,P16615,P98194,P08195,P23634,P20674,P12235,P05023,Q15043,P06576,P35670,P05141,P00403,P12236,P36543,P51790,Q9Y6M7 27 +Steroid binding 0.7603116263258364 3.5242518038226556 0.0004246804641412 0.441421761628008 0.038815794422509 21 Q14108,P05023,P45880,O15118,O94905,P04062,P30536,P21796,P38435,O00264,Q12770,O95772 12 +Transporter activity 0.6446963140425218 3.4746798010393367 0.0005114634678247 0.5041073458900577 0.041248024375746 167 P41440,Q8N4V1,Q9H9B4,Q9H2D1,Q9NS69,Q9UDW1,Q9Y277,O43808,P21796,Q14728,O60830,O75964,Q8TDW0,P13073,P24539,P45880,O14925,P00846,Q9H0U3,Q9BVC6,P20674,P12235,P17900,P30825,Q9Y6M9,Q9UBX3,Q93050,P00403,Q8WTV0,Q13423,Q9Y487,O75027,O15118,Q9P0J0,Q9HD20,Q7KZN9,P16615,Q70HW3,Q8TAD4,O96000,Q9NZD2,Q9NY64,P08183,Q8TB61,P05023,P49755,Q07820,P38435,Q9NW15,Q96GC9,P04062,O95202,P98194,O43772,O95169,Q9BQT8,Q8IXU6,Q9UJS0,Q15043,L0R6Q1,P30536,P35670,P56385,Q15388,Q6P4A7,Q9HC21,P51790,O95168,Q6NUK1,P20020,Q9UM00,Q04656,O75746,P23634,P06576,Q6P4Q7,Q9Y5J9,Q9UGP8,Q8NE86,O43681,O96008,Q9Y6M7 82 +Tetrapyrrole binding 0.8314639192332293 3.3716528367930874 0.0007471856807772 0.6411226041073065 0.0569106426858673 15 Q6UW02,P30519,Q16850,P09601,Q7KZN9,O43169,O00264 7 +Molecular transducer activity 0.6268010319174203 3.2095885864236338 0.0013292507949751 0.8385589356478088 0.0911201419955462 32 Q99720,Q15375,Q14108,Q8WTV0,Q9Y6I9,Q08722,Q9UBG0,O15118,P11717,P05556,Q99442,P20645,O15031,Q9BUN8,P30536,O75787,Q15629,Q9UGP8 18 +Metal ion transmembrane transporter activity 0.6493795249154055 3.132893089457481 0.0017309247743031 0.906999840019282 0.103178168068244 28 P05026,P16615,P98194,Q9H0U3,Q8N4V1,P20020,P05023,Q9UM00,Q15043,Q04656,P23634,Q6P4Q7,Q8TAD4,Q9HD20,Q9Y6M7,P35670,O95202,Q8NE86 18 +Organic acid transmembrane transporter activity 0.694940294561759 3.0759910414695257 0.0020980414864284 0.94383359765346 0.1198506199122251 20 P08183,P41440,Q9H936,P08195,Q9H9B4,Q9BQT8,O75746,Q9H2D1,P30825,Q96NB2,Q15758,Q9UBX3,Q9UJS0 13 +Alcohol binding 0.7560934114616634 3.04486936220377 0.0023278139815621 0.9590397532639235 0.1276573187488667 16 Q14108,P45880,O15118,O94905,P30536,P21796,O95772 7 +Atpase coupled transmembrane transporter activity 0.6854017333380243 3.014985212206726 0.0025699178524121 0.9706332593904808 0.1355137452175775 20 P08183,P16615,P98194,Q15388,O75027,P20020,P05023,Q04656,P23634,Q9HD20,P35670 11 +Oxidoreduction driven active transmembrane transporter activity 0.5981143811181958 2.9885087860006845 0.002803424399729 0.9786966814042968 0.1397768360705558 32 P13073,P20674,O95169,Q9P0J0,Q9Y6M9,Q9UDW1,O96000,Q7KZN9,P00403 9 +Secondary active transmembrane transporter activity 0.6804239110598449 2.9829689906347463 0.0028546691538844 0.9801459705350216 0.1397768360705558 20 P12236,P41440,Q9H936,P12235,P08195,Q15043,Q15758,Q02978,Q9Y6M7,Q9UBX3,P51790,P05141,O95202,Q8NE86 14 +Sterol binding 0.7267831656545657 2.9652665540843133 0.0030242077130586 0.9842744879085904 0.1429720267104633 17 Q14108,P45880,O15118,O94905,P30536,P21796,Q12770,O95772 8 +Passive transmembrane transporter activity 0.5917721671022151 2.9388561160017495 0.0032942596690417 0.9891532038790204 0.1477266234004855 32 Q9BVC6,Q9NW15,P0CG08,P24539,Q8NE86,Q9UM00,P45880,P06576,Q9Y277,O96008,Q4KMQ2,P51790,P21796,P56385,P00846,O75964,Q8TDW0 17 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 0.6132779567332275 2.924686672318364 0.0034480320560288 0.9912212441973728 0.1477266234004855 29 Q6UW02,Q14534,Q32P28,P30519,P16435,Q16850,Q15800,Q9NVH6,P09601,O75845 10 +Cholesterol binding 0.7811125306351924 2.8793258202760676 0.0039852637041957 0.9958085682045834 0.1564099593749786 13 Q14108,P45880,O15118,O94905,P30536,P21796,O95772 7 +Protein transporter activity 0.7806028946885974 2.876618669475965 0.004019610225642 0.9960021205482518 0.1564099593749786 13 Q15388,Q9NS69,Q9Y5J9,Q9HD20,P49755,Q07820,O14925,O60830,Q9UGP8 9 +Hydrolase activity hydrolyzing o glycosyl compounds 0.661079368028795 2.8573596193576747 0.0042718154673959 0.9971748788447594 0.1564099593749786 20 P06280,P08236,Q9NUJ1,P17900,Q9BTY2,P10253,P04062,P04066,P16278,P54802,P06865 11 +Monooxygenase activity 0.8512820149683747 2.793269117971348 0.0052178262258557 0.9992324969897124 0.174479018430445 9 Q6UW02,Q14534,P30519,Q16850,P09601 5 +Hydrolase activity acting on glycosyl bonds 0.6084088484940623 2.7842694739217517 0.0053648441821516 0.9993732745413636 0.1747185961341496 27 P06280,O75503,P08236,Q9NUJ1,P17900,Q9BTY2,P10253,P04062,P04066,P16278,P54802,P06865 12 +Serine hydrolase activity 0.6803547286722358 2.7773822911069037 0.0054798684418442 0.9994651691324776 0.1747185961341496 18 O14773,Q9H3G5,Q9H300,P42785,P10619,O75976,Q9HB40,Q5JRX3 8 +Sphingolipid binding 0.9325626204238856 2.7109170681320856 0.0067097405871754 0.9999019521297544 0.208871363946809 6 P45880,Q99623,Q9UM22,Q9NZD2,P21796 5 +Metalloendopeptidase activity 0.7078515753838509 2.684296090577555 0.007268270496237 0.9999546540056098 0.2120169968157649 15 Q96E52,P22695,Q10713,O75844,P42892 5 +Lipase activity 0.6464640260895302 2.6585950236667735 0.0078467219546667 0.9999796063065574 0.2211322682303778 19 P38571,Q9H6V9,Q8NCG7,Q8IV08,Q9NZC3,P09601,Q8NCC3,Q8NHP8 8 +Oxidoreductase activity acting on a heme group of donors 0.8875861672840456 2.64920631866534 0.0080681060335703 0.999984981638588 0.2211322682303778 7 Q7KZN9,P13073,P20674,P00403 4 +Macromolecule transmembrane transporter activity 0.7699536512830881 2.635386128843056 0.0084041619002241 0.9999905622766472 0.2211322682303778 11 Q15388,Q9NS69,P49755,Q07820,O14925,O60830,Q9UGP8 7 +Nucleobase containing compound transmembrane transporter activity 0.7463320264453296 2.598801851920228 0.0093549756071202 0.999997466833035 0.2211322682303778 12 P12236,P41440,P12235,Q6NUK1,Q8TB61,Q9H2D1,L0R6Q1,Q9HC21,O43808 9 +Transition metal ion transmembrane transporter activity 0.8740764535817479 2.589653844269149 0.0096072483852265 0.9999982134368934 0.2222305417867424 7 P98194,Q8N4V1,Q15043,Q8TAD4,Q9HD20,P35670 6 +Protein transmembrane transporter activity 0.7819042290747507 2.573630635057267 0.0100637647033889 0.9999990504880792 0.2222305417867424 10 Q15388,Q9NS69,P49755,Q07820,O14925,O60830,Q9UGP8 7 +Ceramide binding 0.9322632423756024 2.5636633280325505 0.0103573957043761 0.9999993677865197 0.2222305417867424 5 Q9NZD2,P21796,Q9UM22,P45880 4 +Electron transfer activity 0.4880520873027676 2.55468445083657 0.0106284100918994 0.999999565704012 0.2222305417867424 55 P13073,P14406,P20674,O95169,O95168,P16435,Q9P0J0,Q9Y6M9,Q9UDW1,P21912,O96000,Q7KZN9,P00403 13 +Lipid transporter activity 0.6561694891614364 2.536718234525085 0.0111896975033658 0.999999800520024 0.2222305417867424 17 P08183,P17900,Q96GC9,O15118,Q9NZD2 5 +Serine type exopeptidase activity 0.8517525976335646 2.490273419406402 0.012764485561528 0.9999999775675954 0.2222305417867424 7 O14773,P42785,Q9HB40,Q9H3G5 4 +Nucleotide transmembrane transporter activity 0.763145371741759 2.4791036476511628 0.0131713025587885 0.9999999872512578 0.2222305417867424 10 P12236,P41440,P12235,Q6NUK1,Q8TB61,Q9H2D1,Q9HC21,O43808 8 +Organophosphate ester transmembrane transporter activity 0.763145371741759 2.4791036476511628 0.0131713025587885 0.9999999872512578 0.2222305417867424 10 P12236,P41440,P12235,Q6NUK1,Q8TB61,Q9H2D1,Q9HC21,O43808 8 +Snap receptor activity 0.6591056624883049 2.4726000728373676 0.0134134153621232 0.9999999908931736 0.2222305417867424 16 O15400,Q9P2W9,O60499,O95249,O95721,O43752,Q12846,O75396,Q13190,Q12981 10 +P type transmembrane transporter activity 0.803858379401146 2.460033923486041 0.0138923883672774 0.9999999953201656 0.2222305417867424 8 P16615,P98194,P20020,P05023,Q04656,P35670 6 +Exogenous protein binding 0.6526503522618425 2.4330586406700534 0.0149718759165773 0.9999999989575088 0.2222305417867424 16 Q14108,Q8WTV0,O15118,P35613,P11279,P78310 6 +Hexosyltransferase activity 0.5347599619184878 2.422387966780566 0.0154188792915879 0.9999999994404848 0.2222305417867424 31 O43505,Q10472,Q9BT22,P46977,P04062,Q9BV10,Q96L58,P06865 8 +Exopeptidase activity 0.527671355929964 2.420308529567357 0.0155073435330908 0.9999999995053348 0.2222305417867424 32 O14773,Q9H3G5,Q9NZ08,Q969V3,P09960,P42785,O75976,P55786,Q9HB40,Q8IYS1,Q9UIQ6,O75844,P10619 13 +Acid phosphatase activity 0.8970229295569911 2.416155524618346 0.0156853600785689 0.999999999613955 0.2222305417867424 5 Q9NPH0 1 +Inorganic anion transmembrane transporter activity 0.6194629524634068 2.3894999335891915 0.0168713269121418 0.9999999999260724 0.2248349377191768 18 Q9NW15,O43681,P45880,Q15043,Q9UBX3,Q9Y277,P51790,Q4KMQ2,P21796,Q9Y6M7,Q8TDW0 11 +Serine type carboxypeptidase activity 0.8900956714142501 2.386859515116223 0.0169929834136064 0.9999999999376088 0.2248349377191768 5 P42785,Q9HB40,Q9H3G5 3 +Vitamin transmembrane transporter activity 0.8228411838806224 2.3597366307935994 0.0182879133296072 0.9999999999897612 0.2294292841570626 7 Q9H2D1,P04062,Q9HC21,P38435,Q9NY64 5 +Carbohydrate derivative transmembrane transporter activity 0.7608460734655828 2.356169019437619 0.0184645141380099 0.9999999999919992 0.2294292841570626 9 P12236,P41440,P12235,Q6NUK1,Q8TB61,L0R6Q1,O43808 7 +Scavenger receptor activity 0.9589233157867718 2.343474501895226 0.019105068085115 0.9999999999967308 0.2294292841570626 4 Q14108,Q8WTV0 2 +Atpase coupled cation transmembrane transporter activity 0.6364335600003376 2.3328904787682454 0.0196538942267421 0.9999999999984822 0.2294292841570626 16 P16615,P98194,P20020,P05023,Q04656,P23634,Q9HD20,P35670 8 +Antiporter activity 0.7502410800385636 2.3033436902192275 0.0212595132711885 0.9999999999998396 0.2294292841570626 9 P12236,P41440,P12235,P08195,Q9UBX3,P51790,P05141,O95202 8 +Palmitoyltransferase activity 0.8340074020496685 2.2845320857605023 0.0223402791220399 0.9999999999999648 0.2294292841570626 6 O15269,P23786,P50416 3 +Proton channel activity 0.7033140449692006 2.2840791282870536 0.0223668809750063 0.999999999999966 0.2294292841570626 11 P56385,P24539,P00846,O75964 4 +Proton transporting atp synthase activity rotational mechanism 0.7033140449692006 2.2840791282870536 0.0223668809750063 0.999999999999966 0.2294292841570626 11 P56385,P24539,P00846,O75964 4 +Cation channel activity 0.5719849800999718 2.283105400648248 0.0224241605230097 0.9999999999999688 0.2294292841570626 21 Q9NW15,P24539,Q9UM00,P06576,P56385,P00846,O75964 7 +Endopeptidase activity 0.4500793969403095 2.2661770174775167 0.0234405471966616 0.9999999999999925 0.2317298943332049 58 P28074,O14773,P49721,Q9H300,Q92643,P45974,Q92542,Q10713,Q16740,Q4J6C6,Q9Y4W6,P22695,O75844,P42892,Q96E52,Q9NZ08,Q96K76,Q96RU2,Q8TCT9,Q5JRX3 20 +Phosphatidylcholine binding 0.7606846969455084 2.252869986827677 0.0242673477558694 0.9999999999999976 0.2359612324347308 8 P21796,Q14108 2 +Purine nucleotide transmembrane transporter activity 0.7592255769754928 2.245777774990596 0.0247182455670915 0.9999999999999988 0.2386529202287503 8 P12236,P41440,P12235,Q6NUK1,Q8TB61,O43808 6 +Cargo receptor activity 0.7940567029985466 2.2276923660262646 0.0259010364381298 0.9999999999999998 0.2465994510880274 7 Q5JRA6,Q14108,Q8WTV0,Q08380,O15260 5 +Dicarboxylic acid transmembrane transporter activity 0.7499999999999829 2.200797669287297 0.0277503506751837 1.0 0.2553404750045428 8 Q9H936,P41440,Q9BQT8,O75746,Q15758,Q9UBX3,Q9UJS0 7 +Amino acid transmembrane transporter activity 0.7056923198754572 2.1826371017903767 0.0290625452564865 1.0 0.2656316636442871 10 P08195,Q9H9B4,O75746,P30825,Q15758,Q96NB2,Q9UJS0 7 +Collagen binding 0.7454327619685348 2.178441329968767 0.0293731957153462 1.0 0.266693055137349 8 O75718,Q32P28,Q9UBG0,Q92791,Q53GQ0 5 +Abc type transporter activity 0.9169019713859772 2.1739250389349745 0.0297107652657517 1.0 0.2679832840746427 4 Q9HD20,O75027 2 +Glycolipid binding 0.7375549407631656 2.1397422997552087 0.032375598560798 1.0 0.2801090534057779 8 O14773,P50897,Q9UM22,Q9NZJ7,Q9NZD2 5 +Syntaxin binding 0.5807000168371236 2.132928787624855 0.0329305683958769 1.0 0.2801090534057779 18 O15400,O95721,O60499,Q9P253,P49755 5 +Porin activity 0.9058151096950652 2.128696365717083 0.0332793897230625 1.0 0.2801090534057779 4 P21796,Q9Y277 2 +Wide pore channel activity 0.9058151096950652 2.128696365717083 0.0332793897230625 1.0 0.2801090534057779 4 P21796,Q9Y277 2 +Carboxypeptidase activity 0.6606407702570496 2.1284168759550317 0.0333025351605702 1.0 0.2801090534057779 12 Q9H3G5,P42785,O75976,Q9HB40,P10619 5 +Mannosyltransferase activity 0.7978833608508549 2.122714820786378 0.03377775630845 1.0 0.2801676042166512 6 Q9BV10,Q9BT22 2 +Phospholipid binding 0.4372253684694697 2.1223303923641432 0.0338100029911137 1.0 0.2801676042166512 83 O14773,O60749,Q14108,Q8WTV0,Q9BWH2,P50897,P45880,O60313,Q9UM22,Q9H4A6,Q9NZJ7,Q8NCC3,P21796,Q9NZD2 14 +Sulfur compound transmembrane transporter activity 0.8271904817902066 2.1162974557937684 0.0343195170024439 1.0 0.2817488491637764 5 Q8TB61,Q9UBX3,Q70HW3 3 +Voltage gated anion channel activity 0.795118818240181 2.1102080793010716 0.0348404369329364 1.0 0.2843228513991424 6 P45880,Q9Y277,P51790,Q4KMQ2,P21796 5 +O acyltransferase activity 0.6562385486036101 2.103525584870849 0.035419851215922 1.0 0.2865347923244284 12 Q8NCC3,Q8NF37,P23786,P50416 4 +Mhc class i protein binding 0.7663694077515533 2.0987059333348412 0.0358428313208898 1.0 0.2873714721692395 7 P07437,Q9BUN8,P51572,P68371 4 +Atpase binding 0.5070364230666793 2.049370515847681 0.0404258980637091 1.0 0.2876804627546107 28 P05026,Q9Y487,P36543,Q5JTV8,Q92542,P54709,Q9BUN8,P40855,O76024,Q16740,Q93050,Q9NWS0 12 +Iron ion binding 0.5373299737003611 2.033450482459387 0.04200703150784 1.0 0.2960888818107203 21 Q6UW02,P22830,P02792,Q32P28,Q9BU89,Q16850,Q15800,Q9NVH6,P13674,O75845 10 +Prenyltransferase activity 0.7515689254726959 2.0289603366707265 0.0424623303571993 1.0 0.2960888818107203 7 O95749,P14324,P37268 3 +L amino acid transmembrane transporter activity 0.7149798600608746 2.0278807015193174 0.042572425214991 1.0 0.2960888818107203 8 P08195,Q9H9B4,O75746,P30825,Q15758,Q9UJS0 6 +Fad binding 0.6754497673720956 2.022300555070966 0.0431453113298188 1.0 0.2960888818107203 10 Q14534,O95831,Q15392,Q96HE7,O00116,Q8NB78,Q15067 7 +Metallopeptidase activity 0.4678367977075699 2.0151238019892133 0.0438916788697838 1.0 0.2977765214206598 41 Q96E52,Q9NZ08,Q969V3,P22695,O75976,P55786,Q10713,Q9UIQ6,O75844,Q5JRX3,P42892 11 +Mhc protein binding 0.7112693138973102 2.009358294322898 0.0444991498114726 1.0 0.2977765214206598 8 P07437,Q9BUN8,P51572,P68371 4 +Phospholipase activity 0.5852987054440631 2.0091115933997266 0.0445253004312438 1.0 0.2977765214206598 16 Q8NCC3,Q8IV08,P09601,Q8NHP8 4 +Palmitoyl protein hydrolase activity 0.767564122646281 1.9846028985303856 0.0471886696118861 1.0 0.3116959951756418 6 Q9UMR5,P50897 2 +Udp glycosyltransferase activity 0.6204797682274956 1.9783836246252535 0.0478854456483293 1.0 0.3116959951756418 13 O43505,Q10472,P06865 3 +Hexosaminidase activity 0.7956572955311144 1.9776277315336264 0.0479707184405984 1.0 0.3116959951756418 5 P17900,P54802 2 +P type calcium transporter activity 0.8620025673940899 1.9480008045903736 0.0514148668786345 1.0 0.3283541287323437 4 P20020,P16615,P98194 3 +Galactosyltransferase activity 0.8618467909955985 1.9473528907231403 0.0514924417778657 1.0 0.3283541287323437 4 O43505 1 +Phospholipid transporter activity 0.7295531307509526 1.92419614077857 0.0543300026934026 1.0 0.3400477771242182 7 P08183,Q9NZD2 2 +2 iron 2 sulfur cluster binding 0.6371981167822987 1.9203443970464629 0.0548144119215552 1.0 0.3400477771242182 11 P21912,P22830,Q9NZ45 3 +Phosphatidylserine binding 0.6745208150630674 1.9163536335805655 0.0553200983598101 1.0 0.3410426875915609 9 Q14108 1 +Protein carrier chaperone 0.6555447321206179 1.9151584691804209 0.0554722971064318 1.0 0.3410426875915609 10 Q9NPA0,P40855,Q15070,Q8N4V1 4 +C4 dicarboxylate transmembrane transporter activity 0.749518304431585 1.9014200356993456 0.0572470172670456 1.0 0.348825158547198 6 Q9H936,O75746,Q15758,Q9UBX3,Q9UJS0 5 +Acylglycerol o acyltransferase activity 0.7242515102570622 1.8987877941473088 0.0575923826786333 1.0 0.3493767993469304 7 Q8NCC3,Q96N66,Q8NF37 3 +Organic cation transmembrane transporter activity 0.7481136508888238 1.894915079482513 0.0581036530680787 1.0 0.3493934640642545 6 Q70HW3,Q9HC21,O43772 3 +Copper ion binding 0.6042266934860536 1.8816880600406496 0.0598783818387635 1.0 0.3538502650902797 13 Q8N668,Q04656,Q9Y6N1,O75880,P35670,O43819,P00403 7 +Cytokine activity 0.7436579187688308 1.8742520560389824 0.0608956922646759 1.0 0.3578705398069228 6 Q92520 1 +Lamin binding 0.6656093134568924 1.8696824830260264 0.061527923460843 1.0 0.3581214929834757 9 Q14739,Q5JTV8,O94901,Q5SNT2,Q9UH99,P42167,Q9ULX6 7 +Quinone binding 0.7706126649634308 1.8660900553511248 0.0620287670795032 1.0 0.3581214929834757 5 Q16134,P21912,Q8N0U8 3 +Translation repressor activity 0.681966561909445 1.8617467055449477 0.062638801816699 1.0 0.3581214929834757 8 Q14011,P00374 2 +Atp transmembrane transporter activity 0.7672552166934203 1.8510459140692164 0.064162948036321 1.0 0.3615883567966675 5 P12236,P12235,Q6NUK1,O43808 4 +Oxidoreductase activity acting on nad p h 0.4717727148779381 1.8443814770779736 0.0651275648334117 1.0 0.3615883567966675 30 O95169,Q13423,P16435,O95831,Q9P0J0,Q9Y6M9,O96000,Q7KZN9 8 +Quaternary ammonium group binding 0.5953935164869322 1.8287095628855825 0.0674431291251231 1.0 0.3647084195867566 13 P21796,Q14108 2 +Anion channel activity 0.639492645848291 1.8278356463365113 0.0675742216345756 1.0 0.3647084195867566 10 Q9NW15,P45880,Q9Y277,P51790,Q4KMQ2,P21796,Q8TDW0 7 +Mannose binding 0.7323696916623629 1.821711753307261 0.0684987336516826 1.0 0.3654154234881593 6 O75503,P35613,Q12907,P11717 4 +Calcium ion binding 0.4050279062739695 1.7832091609665404 0.0745522617762584 1.0 0.3871634503607964 80 Q6NUK1,Q9UBV8,Q9NWM8,O95202,P16615,Q8NF37,P80303,Q02818,Q15293,O75746,Q9H4M9,P41208,Q9UM22,Q96D71,Q9UJS0,P04350,P27824,O60476,Q9BRK5,Q9H223,P43304,O43852,Q14257,Q9BPX6,P20073,O43681,P55327,Q14118,Q96A33,Q8IYU8 30 +Solute anion antiporter activity 0.7492776886035327 1.7701354127242566 0.0767045855144701 1.0 0.3879247232812104 5 P12236,P41440,P12235,P05141 4 +Pdz domain binding 0.5456103449362536 1.749489795118961 0.0802063912567261 1.0 0.3927539020320507 16 P20020,Q9BXI6,P23634,P51790,P78310,Q15067 6 +Lysophosphatidic acid binding 0.9865298268120588 1.7422576750702672 0.0814633659338217 1.0 0.3954353754739505 2 O14773 1 +Sodium ion transmembrane transporter activity 0.6912301559784044 1.738992311243169 0.0820361153681721 1.0 0.3960264583442394 7 P05026,P08195,P05023,Q6P4Q7,Q9Y6M7 5 +Membrane insertase activity 0.6575848784627623 1.7371534055725038 0.0823600968084308 1.0 0.3961954130679251 8 Q15006,Q9NPA0,Q15070,Q8N4V1 4 +Sulfotransferase activity 0.9820397690827471 1.723692804558283 0.0847633146758246 1.0 0.4007258773122606 2 Q7LGA3 1 +Lysophospholipid acyltransferase activity 0.6998241935781787 1.6687384538800032 0.095169224736257 1.0 0.4393165222673681 6 Q8NF37,Q96N66,Q9NUQ2 3 +Calcium ion transmembrane transporter activity 0.5557913653265445 1.6659508509168666 0.095723204124817 1.0 0.4398374515355795 14 P16615,P98194,P20020,Q9UM00,P23634,O95202 6 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen 0.9637588197562574 1.6480032080369134 0.0993520128786429 1.0 0.4510318200550464 2 P30519 1 +Phospholipase d activity 0.963758819756254 1.6480032080368971 0.0993520128786462 1.0 0.4510318200550464 2 Q8IV08 1 +Gated channel activity 0.5630380566530367 1.6321559734137494 0.1026466327995643 1.0 0.4548544974870022 13 Q9BVC6,Q9NW15,P45880,Q9Y277,P51790,Q4KMQ2,P21796 7 +Phosphatidylinositol phosphate phosphatase activity 0.784326629986551 1.6205889106733469 0.1051058320737894 1.0 0.4602019605547747 4 Q10713,Q9NTJ5 2 +Folic acid binding 0.7820791152147754 1.6109988980792551 0.10717996261859 1.0 0.4602019605547747 4 P00374 1 +Peptide binding 0.3729435126523729 1.6062030430277263 0.1082293049758296 1.0 0.4608148357821813 64 O14773,O15212,P10321,Q15388,Q8WTV0,Q9H7Z7,Q9NZ08,P55786,Q15392,P52292,Q9UIQ6,O00264,P42892,P24390 14 +Carnitine o acyltransferase activity 0.949326491340603 1.5881568732825069 0.112250870429079 1.0 0.4647854836127912 2 P23786 1 +O palmitoyltransferase activity 0.949326491340603 1.5881568732825069 0.112250870429079 1.0 0.4647854836127912 2 P23786 1 +Oligosaccharyl transferase activity 0.7766161290119891 1.587665452969813 0.1123620089686454 1.0 0.4647854836127912 4 P46977 1 +Dolichyl diphosphooligosaccharide protein glycotransferase activity 0.7766161290119891 1.587665452969813 0.1123620089686454 1.0 0.4647854836127912 4 P46977 1 +Galactoside binding 0.949005772931366 1.5868262949887892 0.1125519916553221 1.0 0.4647854836127912 2 P16278 1 +Galactosidase activity 0.949005772931366 1.5868262949887892 0.1125519916553221 1.0 0.4647854836127912 2 P16278 1 +Misfolded protein binding 0.5520929935392618 1.564814173889187 0.1176264873304964 1.0 0.474311512147384 13 Q13217,Q9BUN8,P48723 3 +Amyloid beta binding 0.6055522905714547 1.5492933643840736 0.1213112141752308 1.0 0.4862127244376675 9 O15212,O00264,Q8WTV0 3 +Adp transmembrane transporter activity 0.7670089858793273 1.5465554433434625 0.1219704809502069 1.0 0.4862127244376675 4 P12236,P12235,O43808 3 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen 0.9239653512993248 1.5389753769205907 0.123810307606448 1.0 0.4862127244376675 3 Q16850,Q14534 2 +Voltage gated channel activity 0.5703828653490371 1.5376075760155037 0.1241445939597738 1.0 0.4862127244376675 11 P21796,Q9Y277 2 +Steroid dehydrogenase activity 0.6502646723808838 1.537258276190673 0.1242300745472824 1.0 0.4862127244376675 7 Q3SXM5 1 +Peptide antigen binding 0.7644415917843292 1.5355537099764378 0.1246478746361479 1.0 0.4862127244376675 4 P10321,Q15392,P04439 3 +Ganglioside binding 0.931366260423356 1.513618979496084 0.1301225045740168 1.0 0.4983183066228411 2 Q9UM22 1 +Glycosphingolipid binding 0.931366260423356 1.513618979496084 0.1301225045740168 1.0 0.4983183066228411 2 Q9UM22 1 +Growth factor receptor binding 0.5189497105079307 1.5113771761573749 0.1306923810235696 1.0 0.4991065581707908 15 O60749,Q9NZ08,Q92542,O00560,Q9H2J4,Q3ZCQ8,Q92600 7 +Acidic amino acid transmembrane transporter activity 0.7538510911424794 1.4901074013044664 0.1361959984312313 1.0 0.5072943687057337 4 O75746,Q9UJS0,Q15758 3 +L aspartate transmembrane transporter activity 0.7538510911424794 1.4901074013044664 0.1361959984312313 1.0 0.5072943687057337 4 O75746,Q9UJS0,Q15758 3 +Oxidoreductase activity acting on a sulfur group of donors oxygen as acceptor 0.7525673940949639 1.484592129406509 0.1376519016464621 1.0 0.5072943687057337 4 Q6ZRP7,Q9UHG3,Q96HE7 3 +Beta n acetylhexosaminidase activity 0.7495246472390815 1.4715139205088654 0.141152185687148 1.0 0.5111832758720992 4 P17900,P06865 2 +Aspartic endopeptidase activity intramembrane cleaving 0.9198203976908268 1.4656941095739373 0.1427316396263482 1.0 0.5111832758720992 2 Q92542 1 +Phosphatidic acid binding 0.7418459991655719 1.4384782837575962 0.1502983947977199 1.0 0.519755636919004 4 O60313 1 +Myosin v binding 0.6515989678974912 1.438384442943493 0.1503250042402186 1.0 0.519755636919004 6 Q15907 1 +Vitamin d binding 0.9127645926876202 1.4364140112585373 0.1508845685585438 1.0 0.519755636919004 2 P38435 1 +Manganese ion transmembrane transporter activity 0.89412897016362 1.4223074618577511 0.154937013645938 1.0 0.5237176775189865 3 P98194,Q9HD20 2 +Glutamate receptor binding 0.5972022062772171 1.422243921774493 0.1549554522315852 1.0 0.5237176775189865 8 P23634,P41440,O75955,P27824 4 +Beta 1 3 galactosyltransferase activity 0.9092366901860256 1.4217779593812605 0.1550907199655058 1.0 0.5237176775189865 2 O43505 1 +Catalytic activity acting on a glycoprotein 0.9092366901860256 1.4217779593812605 0.1550907199655058 1.0 0.5237176775189865 2 O43505 1 +Udp galactose beta n acetylglucosamine beta 1 3 galactosyltransferase activity 0.9092366901860256 1.4217779593812605 0.1550907199655058 1.0 0.5237176775189865 2 O43505 1 +2 acylglycerol 3 phosphate o acyltransferase activity 0.9076330981398386 1.415126332891141 0.1570314586722898 1.0 0.5279595803928332 2 Q8NF37 1 +Peptidase activity 0.40527805757035 1.41094639894035 0.1582604194700352 1.0 0.5279595803928332 111 O14773,P28074,P49721,Q92820,Q9H300,O75976,Q92643,Q8IYS1,P45974,Q96FZ2,P42785,Q92542,Q9HB40,Q10713,Q4J6C6,Q16740,Q9UIQ6,Q9H3G5,Q9Y4W6,Q969V3,P09960,P22695,P55786,O75844,P10619,P42892,Q96E52,Q9BT78,Q9NZ08,Q96K76,Q96RU2,P28072,Q15005,Q8TCT9,Q5JRX3 35 +G protein alpha subunit binding 0.891215651176258 1.4109059522466751 0.1582723468573701 1.0 0.5279595803928332 3 P80303 1 +Symporter activity 0.579167067255324 1.4056011556784267 0.15984259268969 1.0 0.5308385646991772 9 Q9H936,Q9Y6M7,Q15043,Q15758 4 +Glycosyltransferase activity 0.3955302125121735 1.3707264845744875 0.1704602354987363 1.0 0.5422296586282309 45 O43505,Q10472,Q9BT22,Q8IXJ6,Q9H6U8,P46977,P04062,P43490,Q9BV10,Q96L58,P06865,Q11206 12 +Iron ion transmembrane transporter activity 0.8938422065426711 1.3579616156658236 0.1744758642402111 1.0 0.5461333558752196 2 Q8N4V1 1 +Zinc ion transmembrane transporter activity 0.8938422065426619 1.3579616156657852 0.1744758642402233 1.0 0.5461333558752196 2 Q8TAD4 1 +Lipid binding 0.4199620363744995 1.3436050276418714 0.1790761428572562 1.0 0.5471297444109415 133 O14773,O15118,P04062,Q99623,Q92643,P21796,Q12770,O95772,Q14108,Q96RU3,Q9BWH2,O75477,P50897,P45880,Q9UM22,Q9NZD2,O60749,Q8NFH5,P05023,O60313,O94905,P30536,Q9H4A6,Q9NZJ7,Q96E52,Q8WTV0,Q9NQZ5,Q9Y5X3,Q9Y371,A6NIH7,Q8NCC3,P38435,O00264,Q15067 34 +Transferase activity transferring sulphur containing groups 0.5674440664109572 1.3412767112017323 0.1798306281702237 1.0 0.5471297444109415 9 Q7LGA3 1 +Thiolester hydrolase activity 0.4925763172185592 1.3358663283973404 0.1815929684060824 1.0 0.5478317477116313 15 Q9UMR5,P50897 2 +Carbohydrate binding 0.3929866143149959 1.33008295867322 0.183490939632013 1.0 0.548571717788065 44 O75503,P08236,Q10472,P27824,P52789,Q32P28,Q9UBG0,P10253,P35613,Q9NPA0,Q9NY64 11 +Aspartic type peptidase activity 0.8693532717793522 1.325346422540799 0.1850562784621128 1.0 0.5501124629514934 3 Q92542 1 +Neutral amino acid transmembrane transporter activity 0.6491307877363617 1.310099804199799 0.190162074683351 1.0 0.5531042415331083 5 Q9H9B4,Q96NB2,P08195 3 +Azole transmembrane transporter activity 0.8816549069916755 1.3075262282857414 0.1910340531290821 1.0 0.5531042415331083 2 P30825 1 +Quaternary ammonium group transmembrane transporter activity 0.881654906991661 1.3075262282856812 0.1910340531291026 1.0 0.5531042415331083 2 O43772 1 +Translation repressor activity mrna regulatory element binding 0.6040378755591338 1.305626038069469 0.1916797611565948 1.0 0.5531042415331083 7 P00374 1 +Solute proton antiporter activity 0.8803720333547141 1.302223082413524 0.1928401367270793 1.0 0.5531042415331083 2 O95202 1 +Sphingolipid transporter activity 0.8581692992399366 1.2816063088808154 0.1999807859456317 1.0 0.5655972553771634 3 Q9NZD2 1 +Copper ion transmembrane transporter activity 0.8726747915330345 1.2704320630502226 0.2039307681959257 1.0 0.5717568163529941 2 P35670 1 +Nadh dehydrogenase activity 0.4308274456244546 1.2661934852940937 0.2054438193356922 1.0 0.5724985290456172 23 O95169,O95831,Q9P0J0,Q9Y6M9,O96000 5 +Hormone binding 0.5962320853227814 1.266181666143846 0.205448049810681 1.0 0.5724985290456172 7 P05023,P42892 2 +Potassium ion transmembrane transporter activity 0.699095557162808 1.253987244733341 0.2098466416698632 1.0 0.5752330073957893 4 P05026,P05023 2 +Snare binding 0.4045001635039765 1.251848512332076 0.2106250690829221 1.0 0.5752330073957893 30 O15400,O95721,O60499,O43752,Q9P253,P49755,Q12846,Q13190 8 +Nadp retinol dehydrogenase activity 0.6344674945734649 1.24182222169132 0.214302161961132 1.0 0.5833642012041463 5 Q8NBN7 1 +Atp dependent peptidase activity 0.6337572543615442 1.2385124343113287 0.2155261144216407 1.0 0.5849602981995569 5 Q9Y4W6,Q16740 2 +5 3 exodeoxyribonuclease activity 0.862732520846712 1.2294501297750176 0.218903084852478 1.0 0.5894246744144352 2 Q8IV08 1 +Retromer complex binding 0.6931964056482549 1.2284960272820615 0.2192608198040568 1.0 0.5894246744144352 4 P20645,P11717,O60493 3 +Metalloexopeptidase activity 0.4429321529354643 1.2267584991131015 0.2199133733196876 1.0 0.5900219859516472 19 Q9NZ08,Q969V3,O75976,P55786,Q9UIQ6,O75844 6 +Nucleotidase activity 0.5841755822840466 1.205117475457428 0.2281579544072562 1.0 0.6016506042289238 7 Q9NX62 1 +Solute cation symporter activity 0.5831682667522077 1.2000089190425356 0.2301358765545849 1.0 0.6048468940557955 7 Q9H936,Q9Y6M7,Q15043 3 +Flavin adenine dinucleotide binding 0.4059617879552262 1.1953459852677129 0.2319518800712861 1.0 0.6068817320185749 28 A1L0T0,P09622,Q14534,Q16134,P16435,O95831,Q15392,Q96HE7,O00116,Q8NB78,Q15067 11 +Structural constituent of postsynapse 0.6180833085158137 1.1654373335791277 0.2438420126806952 1.0 0.6237078346739425 5 P07196 1 +Sulfuric ester hydrolase activity 0.8444515715202148 1.154400538278546 0.2483359945954775 1.0 0.628618030060493 2 P15586 1 +N6 methyladenosine containing rna binding 0.6759412319259047 1.153969327582446 0.2485127441960519 1.0 0.628618030060493 4 P22626,P07910 2 +Phosphotransferase activity for other substituted phosphate groups 0.5701254000767655 1.133789547953366 0.2568828363246482 1.0 0.6426758551114832 7 Q9BVG9 1 +Acetylglucosaminyltransferase activity 0.669619695355644 1.1266955121793485 0.2598712405467183 1.0 0.6477881287082741 4 O43505,P06865 2 +Folic acid transmembrane transporter activity 0.8354714560616018 1.1177129269248545 0.2636896199597878 1.0 0.6536363390912796 2 Q9H2D1 1 +Amide transmembrane transporter activity 0.8354714560616018 1.1177129269248545 0.2636896199597878 1.0 0.6536363390912796 2 Q9H2D1 1 +Modified amino acid transmembrane transporter activity 0.8354714560616018 1.1177129269248545 0.2636896199597878 1.0 0.6536363390912796 2 Q9H2D1 1 +Magnesium ion transmembrane transporter activity 0.8158485723451834 1.1166958683817274 0.2641243850157322 1.0 0.6536363390912796 3 Q6P4Q7,Q8N4V1 2 +Ubiquinone binding 0.833547145606174 1.1098691125049287 0.2670554321408589 1.0 0.65733033656215 2 P21912 1 +Volume sensitive anion channel activity 0.8261706221937137 1.079864839423612 0.2802023725209412 1.0 0.6768768198576816 2 P51790 1 +Lysophospholipase activity 0.5586301113267613 1.0753484028013194 0.282218773229224 1.0 0.6781526284354655 7 Q8NCC3 1 +Ionotropic glutamate receptor binding 0.5746619120644063 1.064861501881626 0.2869386087642698 1.0 0.682973667735788 6 P41440,O75955,P27824 3 +Oxidoreductase activity acting on nad p h heme protein as acceptor 0.6528954225747694 1.0546795172325527 0.2915719226795685 1.0 0.6906796944547362 4 Q7KZN9 1 +Intramembrane lipid transporter activity 0.7982034007057952 1.0484455143623768 0.2944333930208951 1.0 0.6912126401226836 3 P08183,Q96GC9 2 +Glucose binding 0.5506801649870916 1.0349140943448258 0.3007090318110337 1.0 0.6934645695747401 7 Q9NY64 1 +Phosphatidylinositol 4 phosphate binding 0.5684346650255138 1.0345307432063886 0.3008881121964437 1.0 0.6934645695747401 6 Q9H4A6 1 +Phosphoric diester hydrolase activity 0.4769079500593075 1.034479441302977 0.3009120829889289 1.0 0.6934645695747401 12 Q8IV08,Q9NZC3,P09601 3 +Atpase activator activity 0.46570842073052 1.0215399916305177 0.3069986719142537 1.0 0.6946411857315794 13 P05026,Q5JTV8,Q8NFQ8,P54709,O95433,Q96KC8 6 +Molecular function activator activity 0.46570842073052 1.0215399916305177 0.3069986719142537 1.0 0.6946411857315794 13 P05026,Q5JTV8,Q8NFQ8,P54709,O95433,Q96KC8 6 +Threonine type endopeptidase activity 0.5194304377633512 1.0073281489658956 0.3137771069729922 1.0 0.698357814383072 8 P28074 1 +Xenobiotic transmembrane transporter activity 0.7856736959984963 1.0002580897180446 0.3171856236685246 1.0 0.7025226010493495 3 P08183 1 +Modified amino acid binding 0.4015140761408018 0.992023420236637 0.3211861008553525 1.0 0.7062647348475811 21 P41440,Q14108,Q8WTV0,Q9H7Z7,P00374 5 +Solute cation antiporter activity 0.7828039781841427 0.9892597016484348 0.3225360951655518 1.0 0.7062647348475811 3 O95202,P51790 2 +Apolipoprotein binding 0.7785590650423216 0.9730193516705946 0.3305436843186258 1.0 0.7062647348475811 3 Q8WTV0 1 +Intracellular calcium activated chloride channel activity 0.7979474021809033 0.9661753942475466 0.3339564231067666 1.0 0.7062647348475811 2 Q9NW15 1 +Calcium activated cation channel activity 0.7979474021809033 0.9661753942475466 0.3339564231067666 1.0 0.7062647348475811 2 Q9NW15 1 +Ion gated channel activity 0.7979474021809033 0.9661753942475466 0.3339564231067666 1.0 0.7062647348475811 2 Q9NW15 1 +Phospholipid scramblase activity 0.797947402180903 0.9661753942475462 0.3339564231067669 1.0 0.7062647348475811 2 Q96GC9 1 +Voltage gated chloride channel activity 0.7979474021808883 0.9661753942474864 0.3339564231067968 1.0 0.7062647348475811 2 P51790 1 +Ephrin receptor binding 0.5542300963617703 0.9654298630290234 0.3343295499023195 1.0 0.7062647348475811 6 Q15375,P46108,O00560,P18031 4 +Single stranded dna exodeoxyribonuclease activity 0.5739775239670464 0.9601873481763536 0.336960933196178 1.0 0.7082381608312082 5 Q8IV08 1 +Ribosomal large subunit binding 0.5358376712236474 0.959454035028688 0.3373300649327344 1.0 0.7082381608312082 7 Q9NTK5,P98179,P56537 3 +Threonine type peptidase activity 0.4978874039420525 0.955946683535527 0.3390991717710863 1.0 0.7085298785460864 9 P28074 1 +O methyltransferase activity 0.5089117739987976 0.950979585983036 0.3416147388461144 1.0 0.7114755720675706 8 P21964 1 +Lipid transfer activity 0.5340256244192307 0.9502490804179664 0.3419857053191313 1.0 0.7114755720675706 7 Q9NZD2 1 +Tap binding 0.7641963426371582 0.9183484135225084 0.3584364887148501 1.0 0.7193400568699645 3 P10321,P04439 2 +Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amides 0.4657477216466789 0.915529283287526 0.3599138367005374 1.0 0.7193400568699645 11 Q8IYS1,Q13510 2 +P type potassium transmembrane transporter activity 0.7847979474022035 0.9139426965410627 0.3607469569193211 1.0 0.7193400568699645 2 P05023 1 +Molecular carrier activity 0.3600033788220998 0.9136138448117856 0.3609197889601983 1.0 0.7193400568699645 32 Q9C0E2,Q8N4V1,Q15070,Q04656,Q9NPA0,P40855,O75880,O43819,P52292 9 +Phosphoric ester hydrolase activity 0.3175722601761918 0.9103243809757016 0.3626514642642531 1.0 0.72038103529195 64 P11117,P05023,Q8IV08,Q9NPH0,Q9NZC3,P09601,Q10713,Q9NX62,Q969T7 9 +Calcium cation antiporter activity 0.7825529185375422 0.9050800490155516 0.3654229808015523 1.0 0.72038103529195 2 O95202 1 +Cation cation antiporter activity 0.7825529185375422 0.9050800490155516 0.3654229808015523 1.0 0.72038103529195 2 O95202 1 +Serine transmembrane transporter activity 0.7600256657042013 0.9025617342663786 0.3667585431318607 1.0 0.72038103529195 3 Q96NB2,Q9H9B4 2 +Phosphatidylinositol phosphate 4 phosphatase activity 0.752682063878362 0.8748728824014094 0.3816430755077264 1.0 0.7362812367934715 3 Q9NTJ5 1 +Thiol oxidase activity 0.7523259544433728 0.8735338453735195 0.3823721667373712 1.0 0.7362812367934715 3 Q6ZRP7,Q96HE7 2 +Procollagen proline dioxygenase activity 0.752325954443367 0.8735338453734983 0.3823721667373827 1.0 0.7362812367934715 3 Q32P28,P13674 2 +Peptidyl proline dioxygenase activity 0.752325954443367 0.8735338453734983 0.3823721667373827 1.0 0.7362812367934715 3 Q32P28,P13674 2 +Acetylgalactosaminyltransferase activity 0.7732520846696862 0.8685506078045404 0.3850929802238485 1.0 0.7365084636047624 2 Q10472 1 +Polypeptide n acetylgalactosaminyltransferase activity 0.7732520846696862 0.8685506078045404 0.3850929802238485 1.0 0.7365084636047624 2 Q10472 1 +Copper chaperone activity 0.6063486224718654 0.8563298096687134 0.3918153770517318 1.0 0.741959781682216 4 O43819,O75880 2 +Metallochaperone activity 0.6063486224718654 0.8563298096687134 0.3918153770517318 1.0 0.741959781682216 4 O43819,O75880 2 +Leukotriene c4 synthase activity 0.7677998717126349 0.8472856434255989 0.3968359268355486 1.0 0.7441745590937919 2 Q99735 1 +Nucleobase transmembrane transporter activity 0.7665169980756881 0.8422990050468372 0.3996206078402045 1.0 0.7441745590937919 2 P12235 1 +Oxidative phosphorylation uncoupler activity 0.7665169980756881 0.8422990050468372 0.3996206078402045 1.0 0.7441745590937919 2 P12235 1 +Sterol transporter activity 0.5125744072261661 0.8415474396813868 0.4000413202422499 1.0 0.7441745590937919 7 O15118 1 +L serine transmembrane transporter activity 0.7597819114817175 0.8162295160362472 0.414368878362974 1.0 0.7536173923665286 2 Q9H9B4 1 +Glucosidase activity 0.5426703940067604 0.8160665368700534 0.4144620815786743 1.0 0.7536173923665286 5 P04062 1 +Sulfatide binding 0.7357886986103515 0.8117602257483408 0.4169292288685393 1.0 0.7543444303967471 3 O14773 1 +Phosphatidylglycerol binding 0.7565747273893786 0.803883079373244 0.4214645030517201 1.0 0.7543444303967471 2 O60313 1 +Cardiolipin binding 0.7565747273893786 0.803883079373244 0.4214645030517201 1.0 0.7543444303967471 2 O60313 1 +Peptidyl proline 4 dioxygenase activity 0.7520846696600441 0.7866748150514657 0.4314722507500121 1.0 0.7579066156956696 2 P13674 1 +Procollagen proline 4 dioxygenase activity 0.7520846696600441 0.7866748150514657 0.4314722507500121 1.0 0.7579066156956696 2 P13674 1 +Fibronectin binding 0.7236882407044971 0.76712459007005 0.4430074429576149 1.0 0.7663463745035576 3 Q53GQ0 1 +Antigen binding 0.5127663528307268 0.765409394374393 0.4440278006324467 1.0 0.7663463745035576 6 P10321,Q15392,P04439 3 +Carboxylic ester hydrolase activity 0.3434564350426551 0.7650135953419942 0.4442634490450765 1.0 0.7663463745035576 36 P35790,Q9NUJ1,P38571,Q8NCG7,Q9NZC3,Q8NCC3,Q15165 7 +Structural constituent of muscle 0.5113550457562834 0.7586743331834183 0.4480473944179346 1.0 0.7688022249649415 6 Q14118,P67936 2 +Proteoglycan binding 0.7157026084816166 0.7379639004910773 0.4605363862293194 1.0 0.7728217693028115 3 O00560 1 +Oxidoreductase activity acting on single donors with incorporation of molecular oxygen 0.737973059653622 0.7332159352959441 0.4634267376654954 1.0 0.776721341490702 2 Q9BV57 1 +Pyruvate dehydrogenase acetyl transferring kinase activity 0.710619185113891 0.7195343396595459 0.4718117518621465 1.0 0.7835904368135764 3 Q15118,Q15120 2 +Glyceraldehyde 3 phosphate dehydrogenase nadplus non phosphorylating activity 0.5166509917586457 0.6984235822618949 0.4849123327026325 1.0 0.793450038704777 5 P51648 1 +Cyclic nucleotide binding 0.5162118780096342 0.6964611685646177 0.4861400674777627 1.0 0.793450038704777 5 P13861,P41440,Q9Y4G8,P10644 4 +Oxidoreductase activity acting on nad p h quinone or similar compound as acceptor 0.3558703767004945 0.6716494817133039 0.5018068693257796 1.0 0.8122517329936763 24 Q9Y6M9,O96000,O95169,Q9P0J0 4 +Hexokinase activity 0.7174470814625031 0.6573595275132368 0.5109497688022031 1.0 0.8160971921013478 2 P52789 1 +Epidermal growth factor receptor binding 0.4876234303070609 0.6465452155366829 0.5179263244734607 1.0 0.8210067799123987 6 O60749,Q92600 2 +Transmembrane receptor protein tyrosine kinase activity 0.5546377082177638 0.6433244092387054 0.5200136209361799 1.0 0.8210256004731207 4 Q15375 1 +Transmembrane receptor protein kinase activity 0.5546377082177638 0.6433244092387054 0.5200136209361799 1.0 0.8210256004731207 4 Q15375 1 +Structural constituent of synapse 0.4494528358818305 0.6362706253635951 0.5246000474518624 1.0 0.8232191384455214 8 P07196 1 +Structural constituent of cytoskeleton 0.3301668764778615 0.6332255268355231 0.5265863782456273 1.0 0.8232191384455214 35 Q13885,Q9BVA1,Q16204,P07437,Q9BUF5,Q16352,P07197,P08670,P07196,P68371 10 +Histone acetyltransferase binding 0.4836867589305978 0.6281875408734424 0.529881091158616 1.0 0.823658702923427 6 O95905 1 +Protein binding involved in heterotypic cell cell adhesion 0.4993404369546174 0.6217788756071707 0.5340872785164907 1.0 0.8273826653628348 5 Q08722 1 +Dioxygenase activity 0.3769734449138433 0.5913421527674932 0.5542911913042872 1.0 0.8443676010425369 16 P07237,Q32P28,P16435,Q9NVH6,P13674,Q9BV57 6 +Nadph binding 0.4745760549988884 0.5860231852081962 0.5578599343701149 1.0 0.8477721019992879 6 P00374,P04035 2 +Lipase binding 0.6959589480436266 0.5807727263512774 0.5613936389487586 1.0 0.8485895027549593 2 Q96CS3 1 +Anion cation symporter activity 0.6704025001456078 0.5780520429848776 0.5632289833951991 1.0 0.8494905789161914 3 Q15043 1 +Potassium channel inhibitor activity 0.6943553559974311 0.5751869518431753 0.5651648664054136 1.0 0.8505727382509368 2 P20936 1 +Neurexin family protein binding 0.6895445798589062 0.5585452820141961 0.57647209250771 1.0 0.8609403473072663 2 O00560 1 +Mirna binding 0.395382789507085 0.536588855783522 0.5915516436820907 1.0 0.864275682975138 12 P43243,P98175,Q9BWF3,P22626,Q9UGR2 5 +Endopeptidase activator activity 0.527058097722733 0.5351942484895028 0.5925155430092253 1.0 0.864275682975138 4 P61289,Q9UL46 2 +Oxidoreductase activity acting on paired donors with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 0.5262047385779831 0.531929250054485 0.5947749978039207 1.0 0.864275682975138 4 O95864,O75845 2 +Cytoskeletal anchor activity 0.4626076077087085 0.5314043778788176 0.5951385884356362 1.0 0.864275682975138 6 Q9UQB8,Q8TD16,O00560 3 +Laminin binding 0.4782002221022807 0.5305565278682945 0.5957261272148107 1.0 0.864275682975138 5 Q14118 1 +Steroid dehydrogenase activity acting on the ch oh group of donors nad or nadp as acceptor 0.4739226524393489 0.5124786024285457 0.6083160920309889 1.0 0.8723863621072028 5 Q53GQ0 1 +L ascorbic acid binding 0.457254658901609 0.5072961501621076 0.6119470394301456 1.0 0.8748039359619506 6 Q32P28 1 +Nucleoside triphosphate diphosphatase activity 0.4705730242269691 0.4984222735833001 0.6181864408230768 1.0 0.8783269163323668 5 P36639 1 +Cytoskeleton nuclear membrane anchor activity 0.5135111682658569 0.4840172425203718 0.6283736322342084 1.0 0.8844971763789525 4 Q9UH99 1 +Chaperone binding 0.3119017141217096 0.4734739803804916 0.6358750601648335 1.0 0.8904848901797618 41 O15212,Q13217,Q14108,P05023,Q04656,O95433,O43808,Q96KC8 8 +14 3 3 protein binding 0.6374111920189287 0.4691358672721725 0.6389725230668306 1.0 0.891735899614299 3 Q9Y580 1 +Rna polymerase ii general transcription initiation factor activity 0.4484254569473016 0.4680168449190098 0.6397725435969748 1.0 0.891735899614299 6 P29083 1 +G protein beta gamma subunit complex binding 0.4471814015841784 0.4625340784919457 0.6436983698302681 1.0 0.8946960176250879 6 P41208,P04899,P09471 3 +Aldehyde dehydrogenase nad p plus activity 0.4342348836211828 0.4569758352016667 0.647688414496467 1.0 0.8946960176250879 7 P51648 1 +Potassium chloride symporter activity 0.6587556125721588 0.4565168720772241 0.6480183409932256 1.0 0.8946960176250879 2 P55011 1 +Cation chloride symporter activity 0.6587556125721588 0.4565168720772241 0.6480183409932256 1.0 0.8946960176250879 2 P55011 1 +Solute proton symporter activity 0.6552277100705569 0.4453641705873725 0.6560566006275999 1.0 0.8994535994604393 2 Q9H936 1 +Guanyl nucleotide exchange factor activity 0.3098802529515554 0.4408132764084555 0.6593481812504374 1.0 0.901136650992186 32 P80303 1 +C acyltransferase activity 0.3830850579447191 0.4317916014730997 0.6658928841226079 1.0 0.9021137787866556 11 Q9BWD1 1 +Oxidoreductase activity acting on the ch ch group of donors 0.3138670036913315 0.4282408212299639 0.6684757991437511 1.0 0.9047189739645436 30 Q9H7Z7,Q9BY49,Q9NZ01,Q8N8N7,Q15392,Q02127,P21912,Q7KZN9,Q15067 9 +Oxidoreductase activity acting on the aldehyde or oxo group of donors nad or nadp as acceptor 0.3301862436761056 0.4260451076237785 0.6700749775897292 1.0 0.9059889489896634 20 P51648,P30837,Q53GQ0 3 +Anaphase promoting complex binding 0.6478511866581305 0.4224331088168416 0.6727089156731338 1.0 0.9086321924411404 2 Q16763 1 +Oxidoreductase activity acting on a sulfur group of donors 0.3264076028424664 0.4215473548064729 0.6733554394749808 1.0 0.9086321924411404 23 Q9H3N1,Q6ZRP7,P09622,Q9UHG3,Q96HE7,O43819,Q9Y320 7 +Proline rich region binding 0.4505347047800293 0.4163660288479243 0.6771421828062809 1.0 0.911674056589436 5 Q9UI14 1 +Metalloaminopeptidase activity 0.37965759416319 0.4127414074959475 0.6797960837972279 1.0 0.9119377993013692 11 P55786,Q9UIQ6,Q9NZ08 3 +Guanylate kinase activity 0.4490969166786083 0.4106244376604053 0.6813479416397772 1.0 0.9122344023321626 5 Q14168,Q00013 2 +Phospholipase binding 0.4917941651420192 0.4052156178852892 0.685319025895081 1.0 0.913660061416423 4 P07196 1 +Monosaccharide binding 0.3153412328684727 0.4010307742809375 0.6883974666282842 1.0 0.913660061416423 28 O75503,P52789,Q32P28,P35613,Q9NY64 5 +Monocarboxylic acid transmembrane transporter activity 0.4894094993581571 0.3968333796183093 0.6914903340953704 1.0 0.9138240856091968 4 O14745,P53985,O95563 3 +Long chain fatty acid coa ligase activity 0.4894094993581548 0.3968333796183015 0.6914903340953762 1.0 0.9138240856091968 4 O95573,P33121,O60488 3 +Arachidonate coa ligase activity 0.4894094993581548 0.3968333796183015 0.6914903340953762 1.0 0.9138240856091968 4 O95573,P33121,O60488 3 +Oxidoreductase activity acting on the aldehyde or oxo group of donors 0.3247710389283677 0.3920537388084502 0.6950185078325923 1.0 0.9138240856091968 21 P51648,P30837,Q53GQ0 3 +Extracellular matrix binding 0.4298961715199038 0.3878326702994935 0.6981398667693011 1.0 0.9138240856091968 6 Q14118 1 +Hydrolase activity acting on carbon nitrogen but not peptide bonds 0.3202737248541682 0.3841003827055758 0.7009040478430255 1.0 0.9138240856091968 24 Q13510,P00813,Q02127,Q8IYS1 4 +Signaling receptor regulator activity 0.3283702183390937 0.3696244609230358 0.7116623227371 1.0 0.920461362709966 19 Q92520,Q9UMX5 2 +Protein disulfide isomerase activity 0.3947130467718487 0.3630013617594536 0.7166038670800476 1.0 0.9231744815625452 8 Q6ZRP7,Q92643,P07237 3 +Intermediate filament binding 0.4775102744038992 0.3558873380677096 0.7219249385891515 1.0 0.923282733960566 4 P08670 1 +Sodium channel regulator activity 0.4217940115506802 0.3538675857544802 0.7234381200755737 1.0 0.9243556967601226 6 P23634 1 +Insulin receptor binding 0.4178864857880359 0.3377526174282179 0.7355496193849982 1.0 0.9328756042338876 6 O60749 1 +Protein kinase a regulatory subunit binding 0.3890219505944307 0.3362665905572925 0.736669841360472 1.0 0.9329180615955348 8 Q96M27 1 +Dynein heavy chain binding 0.6161000641436817 0.3301965720116074 0.7412514368590819 1.0 0.933145484373347 2 Q9Y6G9 1 +Inositol tetrakisphosphate phosphatase activity 0.6122514432328366 0.3197795501372305 0.749135450901554 1.0 0.9349638933045704 2 Q01968 1 +Gamma tubulin binding 0.4132947976878586 0.3190498963393602 0.7496886765247626 1.0 0.9349638933045704 6 Q14155,Q96SN8,Q9H0H5,O00571,Q9BSJ2 5 +5 3 exonuclease activity 0.3837044708008248 0.3116631559149674 0.7552965315001319 1.0 0.9380243482794368 8 Q8IV08 1 +Rage receptor binding 0.5723452037215313 0.2804682819180626 0.7791182566736314 1.0 0.9500839921370116 3 Q99584,P09429 2 +Phosphatase activity 0.2859929122657684 0.2793191866146901 0.7799998832331494 1.0 0.9500839921370116 51 P11117,P05023,Q9NPH0,Q10713,Q9NX62,Q969T7 6 +Rna strand annealing activity 0.4525032092426291 0.2750943399367323 0.7832437599655595 1.0 0.9506301588927296 4 P51114,P23588,Q15056 3 +Alcohol dehydrogenase nadpplus activity 0.392396030815425 0.2699644460886972 0.7871876062594843 1.0 0.9525456382892789 7 Q8NBN7 1 +Phosphatidylinositol 3 kinase binding 0.5811417575368769 0.2421759688638269 0.808643814959862 1.0 0.968988645011282 2 O14654 1 +Solute sodium symporter activity 0.5546650096483763 0.2365892354521692 0.812975472011847 1.0 0.9698042027283106 3 Q9Y6M7 1 +Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 3 phosphomonoesters 0.575689544579853 0.2298343344697003 0.8182205037562109 1.0 0.9716897751103772 2 P52758 1 +2 oxoglutarate dependent dioxygenase activity 0.3354250220983175 0.2266451013521417 0.8206997189279723 1.0 0.9716897751103772 13 Q32P28,Q9NVH6 2 +Cytochrome b5 reductase activity acting on nad p h 0.533081492039295 0.1879291209057812 0.8509322142538598 1.0 0.9869798806514428 3 P16435 1 +Camp binding 0.5312800769971213 0.1841209412573759 0.853918578571631 1.0 0.9869798806514428 3 P13861,Q9Y4G8 2 +Dystroglycan binding 0.3822193340894676 0.1720276590452504 0.8634157843629888 1.0 0.989958266753736 5 Q14118 1 +1 phosphatidylinositol 4 kinase activity 0.5468248877485502 0.1710290799895406 0.8642008999412889 1.0 0.989958266753736 2 Q9BTU6 1 +Cobalamin binding 0.5248636509464345 0.1708800940406681 0.8643180490913362 1.0 0.989958266753736 3 Q99707,Q96EY8 2 +Protein self association 0.3144726353596774 0.1696274462103091 0.8653031363896495 1.0 0.9900536493272156 15 O43765,Q9BTV4,Q9Y282 3 +Camp dependent protein kinase regulator activity 0.5239011870388299 0.1689377499095394 0.8658456057938233 1.0 0.9900536493272156 3 P13861,P10644 2 +Diacylglycerol binding 0.541693393200766 0.1617396571389971 0.8715108737974193 1.0 0.994044432592564 2 O14735 1 +3 hydroxyacyl coa dehydrogenase activity 0.3612637277365915 0.14594596323333 0.8839640466166718 1.0 1.0 7 Q53GQ0 1 +Protein macromolecule adaptor activity 0.2804860360982776 0.1437212667466409 0.8857205771107579 1.0 1.0 88 Q9UBV8,O15400,O94901,Q9P2W9,Q02790,Q9UQB8,Q13190,P05026,Q92542,O43752,Q12846,P07196,Q86Y82,Q9Y2J2,O00560,O95721,O60499,O95249,P46108,Q9UH99,Q9BTX1,Q12981,Q9P253,P62993,Q8TD16,O75396 26 +Camp dependent protein kinase inhibitor activity 0.5311096856959532 0.1436931392035492 0.8857427890965717 1.0 1.0 2 P13861 1 +Aldo keto reductase nadp activity 0.3444212215267885 0.1435229938044936 0.8858771528053766 1.0 1.0 8 Q8NBN7 1 +Long chain acyl coa dehydrogenase activity 0.400413383856411 0.1340745684731191 0.8933436094699803 1.0 1.0 4 Q9NZ01,P49748 2 +Exodeoxyribonuclease activity 0.3313129581985478 0.1107071952788636 0.9118485400503112 1.0 1.0 9 Q8IV08 1 +Long chain fatty acid transporter activity 0.4892524863650963 0.1067267597271086 0.915005752660096 1.0 1.0 3 P28288,P11166 2 +Udp glucosyltransferase activity 0.3879974326059142 0.1066199552468768 0.9150904868280214 1.0 1.0 4 Q9NYU2,P13807,Q7Z4H8 3 +Cell cell adhesion mediator activity 0.2924032228436012 0.103258920816369 0.917757477724602 1.0 1.0 18 P35613,P61026,Q08722,P78310 4 +Tropomyosin binding 0.4971135343168661 0.0956672105999392 0.9237848835690696 1.0 1.0 2 Q05682 1 +Type i transforming growth factor beta receptor binding 0.4939063502244951 0.0918926102918509 0.926783362753379 1.0 1.0 2 Q9UNH7 1 +Cell adhesion mediator activity 0.2808400040975884 0.0837628609471254 0.933244976879696 1.0 1.0 20 P61026,Q08722,P35613,Q9UQB8,P78310 5 +Gamma catenin binding 0.3735558408215764 0.077856089866078 0.9379425285471684 1.0 1.0 4 P35221,P25054,Q9UJX6 3 +Dynactin binding 0.3437016914913077 0.0745962839079747 0.940535930898866 1.0 1.0 6 Q9Y5X3 1 +G rich strand telomeric dna binding 0.3440427315916706 0.0678018088436089 0.9459434038291046 1.0 1.0 5 P22626 1 +Fatty acid ligase activity 0.3428571428571468 0.0650037313980638 0.9481710293144564 1.0 1.0 5 O95573,Q6P1M0,P33121,O60488 4 +5 deoxyribose 5 phosphate lyase activity 0.4525336754329619 0.053759645545207 0.9571266611883332 1.0 1.0 2 P12956 1 +Signal sequence binding 0.2741435254459055 0.0501243466612854 0.9600232982906942 1.0 1.0 25 Q15388,P52292,P24390 3 +Long chain fatty acyl coa binding 0.4464400256574681 0.0496483680888331 0.9604026019707868 1.0 1.0 2 P22307 1 +Oxidoreductase activity acting on a sulfur group of donors disulfide as acceptor 0.4454778704297586 0.04903078672268 0.9608947611806476 1.0 1.0 2 Q8IXB1 1 +Aminopeptidase activity 0.2958208178005841 0.0479928081229792 0.9617219742904032 1.0 1.0 14 P55786,Q9UIQ6,Q9NZ08 3 +Amino acid cation symporter activity 0.4323284156510526 0.041406829935617 0.9669715679673392 1.0 1.0 2 Q9H936 1 +L glutamine transmembrane transporter activity 0.4323284156510523 0.0414068299356167 0.9669715679673394 1.0 1.0 2 Q15758 1 +Chemoattractant activity 0.3498074454428809 0.0379974954731937 0.9696896789106172 1.0 1.0 4 P17931,P09429,P26583 3 +Dolichyl phosphate mannose protein mannosyltransferase activity 0.4182168056446345 0.034779849657122 0.9722552885535471 1.0 1.0 2 Q6ZXV5 1 +Vascular endothelial growth factor receptor binding 0.3915971776779927 0.0259182240935559 0.9793225642044436 1.0 1.0 2 Q9H2J4 1 +Insulin receptor substrate binding 0.3508659397049362 0.0189030040449975 0.9849184830886076 1.0 1.0 2 P62993 1 +Syntaxin 1 binding 0.4087263394289374 0.0179012043527193 0.985717668234218 1.0 1.0 3 O75150,O00186 2 +G protein coupled serotonin receptor binding 0.3994225216554406 0.012018277469788 0.990411032796762 1.0 1.0 3 P09471,P63096 2 +Nadp binding 0.2759890120392003 0.0110498536670751 0.991183671771476 1.0 1.0 18 P16435,P00374,Q13423 3 +Metal cluster binding 0.2600304006328 0.0093001434095251 0.9925796661278532 1.0 1.0 32 P22830,Q5VV42,Q16134,Q9NZ45,P21912,Q9H3K6 6 +Protein phosphatase 2a binding 0.302391513610533 0.0054575878041631 0.9956454965685158 1.0 1.0 9 Q86XL3 1 +Tumor necrosis factor receptor superfamily binding 0.3202824133504524 0.0008810523358579 0.9992970220349078 1.0 1.0 4 P42224,Q12931,Q13546 3 diff --git a/msigdb_gomf/selections.json b/msigdb_gomf/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..39f9bdf9a9cd2ce77386b01a87c6426ed1788a03 --- /dev/null +++ b/msigdb_gomf/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1 4 alpha oligoglucan phosphorylase activity", "1 acylglycerophosphocholine o acyltransferase activity", "1 alkyl 2 acetylglycerophosphocholine esterase activity", "1 phosphatidylinositol 3 kinase activity", "1 phosphatidylinositol 3 kinase regulator activity", "1 phosphatidylinositol 4 kinase activity", "1 phosphatidylinositol 4 phosphate 3 kinase activity", "1 phosphatidylinositol 4 phosphate 5 kinase activity", "1 phosphatidylinositol binding", "14 3 3 protein binding", "17 beta hydroxysteroid dehydrogenase nadplus activity", "17 beta hydroxysteroid dehydrogenase nadpplus activity", "2 acylglycerol 3 phosphate o acyltransferase activity", "2 iron 2 sulfur cluster binding", "2 oxoglutarate dependent dioxygenase activity", "3 5 dna helicase activity", "3 5 exodeoxyribonuclease activity", "3 5 exonuclease activity", "3 beta hydroxy delta5 steroid dehydrogenase activity", "3 hydroxyacyl coa dehydratase activity", "3 hydroxyacyl coa dehydrogenase activity", "4 iron 4 sulfur cluster binding", "5 3 dna helicase activity", "5 3 exodeoxyribonuclease activity", "5 3 exonuclease activity", "5 deoxyribose 5 phosphate lyase activity", "5s rrna binding", "7s rna binding", "7sk snrna binding", "Abc type transporter activity", "Abc type xenobiotic transporter activity", "Acetyl coa c acetyltransferase activity", "Acetyl coa c acyltransferase activity", "Acetyl coa hydrolase activity", "Acetylcholine receptor binding", "Acetylgalactosaminyltransferase activity", "Acetylglucosaminyltransferase activity", "Acetyltransferase activity", "Acid amino acid ligase activity", "Acid phosphatase activity", "Acid thiol ligase activity", "Acidic amino acid transmembrane transporter activity", "Actin binding", "Actin filament binding", "Actin monomer binding", "Actinin binding", "Active ion transmembrane transporter activity", "Active transmembrane transporter activity", "Acyl carnitine transmembrane transporter activity", "Acyl coa binding", "Acyl coa dehydrogenase activity", "Acyl coa oxidase activity", "Acylglycerol lipase activity", "Acylglycerol o acyltransferase activity", "Acyltransferase activity", "Acyltransferase acyl groups converted into alkyl on transfer", "Adenosine deaminase activity", "Adenyl nucleotide binding", "Adenyl nucleotide exchange factor activity", "Adenylate cyclase binding", "Adenylate kinase activity", "Adenylyltransferase activity", "Adp binding", "Adp ribose diphosphatase activity", "Adp transmembrane transporter activity", "Adrenergic receptor binding", "Alanine transmembrane transporter activity", "Alcohol binding", "Alcohol dehydrogenase activity zinc dependent", "Alcohol dehydrogenase nad p plus activity", "Alcohol dehydrogenase nadpplus activity", "Aldehyde dehydrogenase nad p plus activity", "Aldehyde lyase activity", "Alditol nadpplus 1 oxidoreductase activity", "Aldo keto reductase nadp activity", "Alkali metal ion binding", "Alpha actinin binding", "Alpha catenin binding", "Alpha glucosidase activity", "Alpha tubulin binding", "Amide binding", "Amide transmembrane transporter activity", "Amidine lyase activity", "Amino acid binding", "Amino acid cation symporter activity", "Amino acid proton symporter activity", "Amino acid sodium symporter activity", "Amino acid transmembrane transporter activity", "Aminoacyl trna editing activity", "Aminoacylase activity", "Aminopeptidase activity", "Ammonium transmembrane transporter activity", "Amp activated protein kinase activity", "Amp binding", "Amyloid beta binding", "Anaphase promoting complex binding", "Androgen receptor binding", "Androstan 3 alpha 17 beta diol dehydrogenase activity", "Anion cation symporter activity", "Anion channel activity", "Anion sodium symporter activity", "Anion transmembrane transporter activity", "Ankyrin binding", "Ankyrin repeat binding", "Annealing activity", "Antigen binding", "Antioxidant activity", "Antiporter activity", "Apolipoprotein a i binding", "Apolipoprotein binding", "Apolipoprotein receptor binding", "Arachidonate coa ligase activity", "Arginine binding", "Armadillo repeat domain binding", "Aromatic amino acid transmembrane transporter activity", "Arp2 3 complex binding", "Aryl hydrocarbon receptor binding", "Arylesterase activity", "Arylsulfatase activity", "Aspartic endopeptidase activity intramembrane cleaving", "Aspartic type endopeptidase inhibitor activity", "Aspartic type peptidase activity", "Atp dependent activity", "Atp dependent activity acting on dna", "Atp dependent activity acting on rna", "Atp dependent chromatin remodeler activity", "Atp dependent dna dna annealing activity", "Atp dependent peptidase activity", "Atp dependent protein binding", "Atp hydrolysis activity", "Atp transmembrane transporter activity", "Atpase activator activity", "Atpase binding", "Atpase coupled cation transmembrane transporter activity", "Atpase coupled intramembrane lipid transporter activity", "Atpase coupled ion transmembrane transporter activity", "Atpase coupled transmembrane transporter activity", "Atpase inhibitor activity", "Atpase regulator activity", "Axon guidance receptor activity", "Azole transmembrane transporter activity", "Basal transcription machinery binding", "Basic amino acid transmembrane transporter activity", "Benzodiazepine receptor activity", "Beta 1 3 galactosyltransferase activity", "Beta 2 adrenergic receptor binding", "Beta 2 microglobulin binding", "Beta catenin binding", "Beta galactosidase activity", "Beta galactoside cmp alpha 2 3 sialyltransferase activity", "Beta n acetylhexosaminidase activity", "Beta tubulin binding", "Bh domain binding", "Bh3 domain binding", "Bhlh transcription factor binding", "Bicarbonate transmembrane transporter activity", "Bile acid binding", "Biotin binding", "Box h aca snorna binding", "Branched chain amino acid transmembrane transporter activity", "Bubble dna binding", "C acetyltransferase activity", "C acyltransferase activity", "C methyltransferase activity", "C palmitoyltransferase activity", "C x c chemokine binding", "C x3 c chemokine binding", "C2h2 zinc finger domain binding", "C3hc4 type ring finger domain binding", "C4 dicarboxylate transmembrane transporter activity", "Cadherin binding", "Cadherin binding involved in cell cell adhesion", "Calcium activated cation channel activity", "Calcium cation antiporter activity", "Calcium channel inhibitor activity", "Calcium channel regulator activity", "Calcium dependent cysteine type endopeptidase activity", "Calcium dependent phospholipid binding", "Calcium dependent protein binding", "Calcium dependent protein kinase activity", "Calcium dependent protein serine threonine phosphatase activity", "Calcium independent phospholipase a2 activity", "Calcium ion binding", "Calcium ion transmembrane transporter activity", "Calmodulin binding", "Calmodulin dependent protein kinase activity", "Calmodulin dependent protein phosphatase activity", "Camp binding", "Camp dependent protein kinase activity", "Camp dependent protein kinase inhibitor activity", "Camp dependent protein kinase regulator activity", "Carbohydrate binding", "Carbohydrate derivative transmembrane transporter activity", "Carbohydrate kinase activity", "Carbohydrate phosphatase activity", "Carbohydrate transmembrane transporter activity", "Carbon carbon lyase activity", "Carbon nitrogen ligase activity with glutamine as amido n donor", "Carbon nitrogen lyase activity", "Carbon oxygen lyase activity", "Carbon sulfur lyase activity", "Carbonyl reductase nadph activity", "Carboxy lyase activity", "Carboxylic acid binding", "Carboxylic ester hydrolase activity", "Carboxypeptidase activity", "Card domain binding", "Cardiolipin binding", "Cargo adaptor activity", "Cargo receptor activity", "Carnitine o acyltransferase activity", "Catalytic activity acting on a glycoprotein", "Catalytic activity acting on a nucleic acid", "Catalytic activity acting on a rrna", "Catalytic activity acting on a trna", "Catalytic activity acting on dna", "Catalytic activity acting on rna", "Cation cation antiporter activity", "Cation channel activity", "Cation chloride symporter activity", "Cation transmembrane transporter activity", "Ccr chemokine receptor binding", "Ccr3 chemokine receptor binding", "Ccr5 chemokine receptor binding", "Cdp alcohol phosphatidyltransferase activity", "Cell adhesion mediator activity", "Cell adhesion molecule binding", "Cell adhesive protein binding involved in bundle of his cell purkinje myocyte communication", "Cell cell adhesion mediator activity", "Cell matrix adhesion mediator activity", "Centromeric dna binding", "Ceramide 1 phosphate binding", "Ceramide 1 phosphate transfer activity", "Ceramide binding", "Cgmp binding", "Channel inhibitor activity", "Channel regulator activity", "Chaperone binding", "Chemoattractant activity", "Chemokine binding", "Chemokine receptor binding", "Chemorepellent activity", "Chitin binding", "Chloride channel inhibitor activity", "Chloride channel regulator activity", "Chloride ion binding", "Cholesterol binding", "Choline transmembrane transporter activity", "Chondroitin sulfate binding", "Chromatin binding", "Chromatin dna binding", "Chromatin insulator sequence binding", "Chromo shadow domain binding", "Cis regulatory region sequence specific dna binding", "Cis trans isomerase activity", "Class i dna apurinic or apyrimidinic site endonuclease activity", "Clathrin binding", "Clathrin heavy chain binding", "Clathrin light chain binding", "Co smad binding", "Coa hydrolase activity", "Coa transferase activity", "Cobalamin binding", "Collagen binding", "Collagen binding involved in cell matrix adhesion", "Complement binding", "Complement component c1q complex binding", "Complement component c3b binding", "Connexin binding", "Copper chaperone activity", "Copper ion binding", "Copper ion transmembrane transporter activity", "Core promoter sequence specific dna binding", "Coreceptor activity", "Coreceptor activity involved in wnt signaling pathway", "Coreceptor activity involved in wnt signaling pathway planar cell polarity pathway", "Corticotropin releasing hormone receptor binding", "Crossover junction endodeoxyribonuclease activity", "Cullin family protein binding", "Cuprous ion binding", "Cxcr chemokine receptor binding", "Cyclase activity", "Cyclic nucleotide binding", "Cyclic nucleotide dependent protein kinase activity", "Cyclic nucleotide phosphodiesterase activity", "Cyclin binding", "Cyclin dependent protein kinase activity", "Cyclin dependent protein serine threonine kinase activator activity", "Cyclin dependent protein serine threonine kinase regulator activity", "Cyclohydrolase activity", "Cyclosporin a binding", "Cysteine type endopeptidase activity", "Cysteine type endopeptidase inhibitor activity", "Cysteine type endopeptidase inhibitor activity involved in apoptotic process", "Cysteine type endopeptidase regulator activity involved in apoptotic process", "Cysteine type exopeptidase activity", "Cysteine type peptidase activity", "Cytidylyltransferase activity", "Cytochrome b5 reductase activity acting on nad p h", "Cytokine activity", "Cytokine binding", "Cytokine receptor binding", "Cytoskeletal anchor activity", "Cytoskeletal motor activity", "Cytoskeletal protein binding", "Cytoskeleton nuclear membrane anchor activity", "D glucose transmembrane transporter activity", "D threo aldose 1 dehydrogenase activity", "D1 dopamine receptor binding", "Damaged dna binding", "Deacetylase activity", "Dead h box rna helicase binding", "Deaminase activity", "Death domain binding", "Death receptor activity", "Death receptor binding", "Dehydroascorbic acid transmembrane transporter activity", "Demethylase activity", "Deoxynucleoside kinase activity", "Deoxyribonuclease activity", "Deoxyribonuclease i activity", "Diacylglycerol binding", "Diacylglycerol kinase activity", "Dicarboxylic acid transmembrane transporter activity", "Dihydropyrimidinase activity", "Dioxygenase activity", "Dipeptidase activity", "Dipeptidyl peptidase activity", "Diphosphotransferase activity", "Disordered domain specific binding", "Disulfide oxidoreductase activity", "Dna apurinic or apyrimidinic site endonuclease activity", "Dna binding bending", "Dna binding transcription activator activity", "Dna binding transcription factor activity", "Dna binding transcription factor binding", "Dna binding transcription repressor activity", "Dna clamp loader activity", "Dna directed dna polymerase activity", "Dna dna annealing activity", "Dna helicase activity", "Dna insertion or deletion binding", "Dna methyltransferase activity", "Dna n glycosylase activity", "Dna polymerase activity", "Dna polymerase binding", "Dna replication origin binding", "Dna secondary structure binding", "Dna topoisomerase activity", "Dna translocase activity", "Dolichyl diphosphooligosaccharide protein glycotransferase activity", "Dolichyl phosphate mannose protein mannosyltransferase activity", "Dopamine receptor binding", "Double stranded methylated dna binding", "Double stranded rna adenosine deaminase activity", "Double stranded rna binding", "Double stranded telomeric dna binding", "Dttp diphosphatase activity", "Dynactin binding", "Dynein complex binding", "Dynein heavy chain binding", "Dynein intermediate chain binding", "Dynein light intermediate chain binding", "Dystroglycan binding", "E box binding", "Efflux transmembrane transporter activity", "Electron transfer activity", "Endodeoxyribonuclease activity", "Endodeoxyribonuclease activity producing 3 phosphomonoesters", "Endodeoxyribonuclease activity producing 5 phosphomonoesters", "Endonuclease activity", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 3 phosphomonoesters", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Endopeptidase activator activity", "Endopeptidase activity", "Endopeptidase regulator activity", "Endopolyphosphatase activity", "Endoribonuclease activity", "Endoribonuclease activity producing 3 phosphomonoesters", "Endoribonuclease activity producing 5 phosphomonoesters", "Enoyl coa hydratase activity", "Enzyme activator activity", "Enzyme inhibitor activity", "Enzyme regulator activity", "Ephrin receptor activity", "Ephrin receptor binding", "Epidermal growth factor receptor binding", "Epoxide hydrolase activity", "Er retention sequence binding", "Erbb 3 class receptor binding", "Estradiol 17 beta dehydrogenase activity", "Estrogen receptor binding", "Ether hydrolase activity", "Eukaryotic initiation factor 4e binding", "Exodeoxyribonuclease activity", "Exogenous protein binding", "Exonuclease activity", "Exonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Exopeptidase activity", "Exoribonuclease activity", "Exoribonuclease activity producing 5 phosphomonoesters", "Extracellular matrix binding", "Extracellular matrix protein binding", "Extracellular matrix structural constituent", "Fad binding", "Fatty acid binding", "Fatty acid derivative binding", "Fatty acid ligase activity", "Fatty acid synthase activity", "Fatty acid transmembrane transporter activity", "Ferric iron binding", "Ferrous iron binding", "Fibroblast growth factor binding", "Fibronectin binding", "Fk506 binding", "Flap endonuclease activity", "Flavin adenine dinucleotide binding", "Flippase activity", "Floppase activity", "Fmn binding", "Folic acid binding", "Folic acid transmembrane transporter activity", "Four way junction dna binding", "Four way junction helicase activity", "Frizzled binding", "Fructose 2 6 bisphosphate 2 phosphatase activity", "Fructose 6 phosphate binding", "Fructose binding", "Fructose transmembrane transporter activity", "Fucosyltransferase activity", "G protein activity", "G protein alpha subunit binding", "G protein beta gamma subunit complex binding", "G protein beta subunit binding", "G protein coupled glutamate receptor binding", "G protein coupled opioid receptor activity", "G protein coupled receptor activity", "G protein coupled receptor binding", "G protein coupled serotonin receptor binding", "G quadruplex dna binding", "G quadruplex rna binding", "G rich strand telomeric dna binding", "Gaba receptor binding", "Galactosidase activity", "Galactoside binding", "Galactosyltransferase activity", "Gamma aminobutyric acid transmembrane transporter activity", "Gamma catenin binding", "Gamma tubulin binding", "Ganglioside binding", "Gated channel activity", "Gdp binding", "Gdp dissociation inhibitor activity", "General transcription initiation factor activity", "General transcription initiation factor binding", "Glucocorticoid receptor binding", "Glucose binding", "Glucosidase activity", "Glucosyltransferase activity", "Glucuronosyltransferase activity", "Glutamate binding", "Glutamate receptor binding", "Glutathione disulfide oxidoreductase activity", "Glutathione oxidoreductase activity", "Glutathione peroxidase activity", "Glutathione transferase activity", "Glyceraldehyde 3 phosphate dehydrogenase nadplus non phosphorylating activity", "Glycerophosphodiester phosphodiesterase activity", "Glycerophospholipid flippase activity", "Glycine binding", "Glycolipid binding", "Glycolipid mannosyltransferase activity", "Glycosaminoglycan binding", "Glycosphingolipid binding", "Glycosyltransferase activity", "Gpi anchor binding", "Gpi linked ephrin receptor activity", "Growth factor activity", "Growth factor binding", "Growth factor receptor binding", "Gtp dependent protein binding", "Gtpase activating protein binding", "Gtpase activator activity", "Gtpase activity", "Gtpase binding", "Gtpase inhibitor activity", "Guanyl nucleotide binding", "Guanyl nucleotide exchange factor activity", "Guanylate kinase activity", "H4 histone acetyltransferase activity", "Heat shock protein binding", "Helicase activity", "Heme transmembrane transporter activity", "Heparan sulfate sulfotransferase activity", "Heparin binding", "Hexokinase activity", "Hexosaminidase activity", "Hexosyltransferase activity", "High density lipoprotein particle binding", "Histone acetyltransferase binding", "Histone arginine n methyltransferase activity", "Histone binding", "Histone deacetylase activity h3 k14 specific", "Histone deacetylase binding", "Histone deacetylase regulator activity", "Histone h3 di monomethyl lysine 9 demethylase activity", "Histone h3 methyl lysine 36 demethylase activity", "Histone h3 methyl lysine 4 demethylase activity", "Histone h3 methyl lysine 9 demethylase activity", "Histone h3 tri di monomethyl lysine 4 demethylase activity", "Histone kinase activity", "Histone lysine n methyltransferase activity", "Histone methyltransferase activity", "Histone methyltransferase activity h3 k36 specific", "Histone methyltransferase activity h3 k4 specific", "Histone methyltransferase activity h3 k9 specific", "Histone methyltransferase activity h4 k20 specific", "Histone methyltransferase binding", "Histone serine kinase activity", "Histone threonine kinase activity", "Hormone activity", "Hormone binding", "Hormone receptor binding", "Hsp70 protein binding", "Hsp90 protein binding", "Hyaluronic acid binding", "Hyalurononglucosaminidase activity", "Hydro lyase activity", "Hydrolase activity acting on acid anhydrides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amidines", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amidines", "Hydrolase activity acting on ester bonds", "Hydrolase activity acting on ether bonds", "Hydrolase activity acting on glycosyl bonds", "Hydrolase activity hydrolyzing n glycosyl compounds", "Hydrolase activity hydrolyzing o glycosyl compounds", "Hydroxymethyl formyl and related transferase activity", "I smad binding", "Identical protein binding", "Ige binding", "Immunoglobulin binding", "Immunoglobulin receptor binding", "Importin alpha family protein binding", "Inorganic anion exchanger activity", "Inorganic anion transmembrane transporter activity", "Inorganic diphosphatase activity", "Inorganic molecular entity transmembrane transporter activity", "Inorganic phosphate transmembrane transporter activity", "Inositol 1 4 5 trisphosphate 5 phosphatase activity", "Inositol bisphosphate phosphatase activity", "Inositol phosphate phosphatase activity", "Inositol polyphosphate 5 phosphatase activity", "Inositol tetrakisphosphate phosphatase activity", "Inositol trisphosphate phosphatase activity", "Insulin binding", "Insulin like growth factor binding", "Insulin like growth factor i binding", "Insulin like growth factor ii binding", "Insulin like growth factor receptor binding", "Insulin receptor binding", "Insulin receptor substrate binding", "Integrin binding", "Interleukin 1 binding", "Interleukin 1 receptor binding", "Interleukin 2 receptor binding", "Interleukin 6 receptor binding", "Intermediate filament binding", "Intracellular calcium activated chloride channel activity", "Intraciliary transport particle b binding", "Intramembrane lipid transporter activity", "Intramolecular oxidoreductase activity", "Intramolecular oxidoreductase activity interconverting aldoses and ketoses", "Intramolecular oxidoreductase activity transposing c c bonds", "Intramolecular transferase activity", "Intramolecular transferase activity phosphotransferases", "Ion gated channel activity", "Ion transmembrane transporter activity", "Ionotropic glutamate receptor binding", "Iron ion binding", "Iron ion transmembrane transporter activity", "Isocitrate dehydrogenase activity", "Isomerase activity", "Isopeptidase activity", "Isoprenoid binding", "Jun kinase binding", "Jun kinase kinase kinase activity", "K48 linked polyubiquitin modification dependent protein binding", "K63 linked polyubiquitin modification dependent protein binding", "Keratin filament binding", "Kinase activator activity", "Kinase activity", "Kinase binding", "Kinase inhibitor activity", "Kinase regulator activity", "Kinesin binding", "Kinetochore binding", "L alanine transmembrane transporter activity", "L amino acid transmembrane transporter activity", "L arginine transmembrane transporter activity", "L ascorbic acid binding", "L aspartate transmembrane transporter activity", "L glutamine transmembrane transporter activity", "L histidine transmembrane transporter activity", "L lactate dehydrogenase activity", "L leucine transmembrane transporter activity", "L lysine transmembrane transporter activity", "L ornithine transmembrane transporter activity", "L serine transmembrane transporter activity", "Lactate dehydrogenase activity", "Lactate transmembrane transporter activity", "Lamin binding", "Laminin 1 binding", "Laminin binding", "Large ribosomal subunit rrna binding", "Lbd domain binding", "Leucine binding", "Leucine zipper domain binding", "Leukotriene c4 synthase activity", "Ligand gated ion channel activity", "Ligase activity", "Ligase activity forming carbon carbon bonds", "Ligase activity forming carbon nitrogen bonds", "Ligase activity forming carbon oxygen bonds", "Ligase activity forming carbon sulfur bonds", "Ligase activity forming phosphoric ester bonds", "Lim domain binding", "Lipase activator activity", "Lipase activity", "Lipase binding", "Lipase inhibitor activity", "Lipid binding", "Lipid kinase activity", "Lipid transfer activity", "Lipid transporter activity", "Lipopolysaccharide binding", "Lipopolysaccharide immune receptor activity", "Lipoprotein particle receptor activity", "Lipoprotein particle receptor binding", "Long chain acyl coa dehydrogenase activity", "Long chain fatty acid binding", "Long chain fatty acid coa ligase activity", "Long chain fatty acid transporter activity", "Long chain fatty acyl coa binding", "Low density lipoprotein particle binding", "Low density lipoprotein particle receptor binding", "Lrr domain binding", "Lyase activity", "Lys48 specific deubiquitinase activity", "Lys63 specific deubiquitinase activity", "Lysine acetylated histone binding", "Lysine n methyltransferase activity", "Lysophosphatidic acid binding", "Lysophosphatidic acid phosphatase activity", "Lysophospholipase activity", "Lysophospholipid acyltransferase activity", "M7g 5 pppn diphosphatase activity", "Macrolide binding", "Macromolecule transmembrane transporter activity", "Magnesium ion binding", "Magnesium ion transmembrane transporter activity", "Malate dehydrogenase activity", "Manganese ion binding", "Manganese ion transmembrane transporter activity", "Mannose binding", "Mannosidase activity", "Mannosyl oligosaccharide 1 2 alpha mannosidase activity", "Mannosyl oligosaccharide mannosidase activity", "Mannosyltransferase activity", "Map kinase activity", "Map kinase kinase activity", "Map kinase kinase kinase activity", "Map kinase kinase kinase kinase activity", "Map kinase phosphatase activity", "Map kinase scaffold activity", "Map kinase tyrosine serine threonine phosphatase activity", "Mdm2 mdm4 family protein binding", "Medium chain fatty acid coa ligase activity", "Membrane insertase activity", "Metal cluster binding", "Metal dependent deubiquitinase activity", "Metal ion proton antiporter activity", "Metal ion transmembrane transporter activity", "Metalloaminopeptidase activity", "Metallocarboxypeptidase activity", "Metallochaperone activity", "Metallodipeptidase activity", "Metalloendopeptidase activity", "Metalloexopeptidase activity", "Metallopeptidase activity", "Methyl cpg binding", "Methylated histone binding", "Mhc class i protein binding", "Mhc class ib protein binding", "Mhc class ii protein complex binding", "Mhc protein binding", "Mhc protein complex binding", "Microfilament motor activity", "Microtubule binding", "Microtubule minus end binding", "Microtubule motor activity", "Microtubule plus end binding", "Minor groove of adenine thymine rich dna binding", "Minus end directed microtubule motor activity", "Mirna binding", "Misfolded protein binding", "Mismatch repair complex binding", "Mismatched dna binding", "Mitochondrial ribosome binding", "Mitochondrion targeting sequence binding", "Mitogen activated protein kinase binding", "Mitogen activated protein kinase kinase binding", "Mitogen activated protein kinase kinase kinase binding", "Mitogen activated protein kinase p38 binding", "Modification dependent protein binding", "Modified amino acid binding", "Modified amino acid transmembrane transporter activity", "Molecular adaptor activity", "Molecular carrier activity", "Molecular function activator activity", "Molecular function inhibitor activity", "Molecular function regulator", "Molecular transducer activity", "Molybdopterin cofactor binding", "Monocarboxylic acid binding", "Monocarboxylic acid transmembrane transporter activity", "Monooxygenase activity", "Monosaccharide binding", "Mrf binding", "Mrna 3 utr au rich region binding", "Mrna 3 utr binding", "Mrna 5 utr binding", "Mrna binding", "Mrna methyltransferase activity", "Muscle alpha actinin binding", "Mutlalpha complex binding", "Myosin binding", "Myosin ii binding", "Myosin light chain binding", "Myosin v binding", "Myristoyltransferase activity", "N acetylgalactosamine 4 o sulfotransferase activity", "N acetyllactosaminide beta 1 3 n acetylglucosaminyltransferase activity", "N acetyltransferase activity", "N acylsphingosine amidohydrolase activity", "N acyltransferase activity", "N methyltransferase activity", "N6 methyladenosine containing rna binding", "Nad binding", "Nad dependent protein deacetylase activity", "Nad p h oxidase h2o2 forming activity", "Nad p plus protein arginine adp ribosyltransferase activity", "Nad retinol dehydrogenase activity", "Nadh dehydrogenase activity", "Nadh pyrophosphatase activity", "Nadp binding", "Nadp retinol dehydrogenase activity", "Nadph binding", "Nadplus adp ribosyltransferase activity", "Nadplus binding", "Nadplus kinase activity", "Nedd8 specific protease activity", "Nedd8 transferase activity", "Neuregulin binding", "Neurexin family protein binding", "Neuroligin family protein binding", "Neuropeptide receptor binding", "Neurotransmitter receptor activity", "Neurotransmitter receptor regulator activity", "Neurotransmitter transmembrane transporter activity", "Neurotrophin binding", "Neurotrophin receptor binding", "Neurotrophin trk receptor binding", "Neutral amino acid transmembrane transporter activity", "Nf kappab binding", "Nf kappab inducing kinase activity", "Nfat protein binding", "Nitric oxide synthase binding", "Nitric oxide synthase regulator activity", "Nitrite reductase activity", "Non membrane spanning protein tyrosine kinase activity", "Non membrane spanning protein tyrosine phosphatase activity", "Notch binding", "Nuclear export signal receptor activity", "Nuclear import signal receptor activity", "Nuclear localization sequence binding", "Nuclear receptor activity", "Nuclear receptor binding", "Nuclear receptor coactivator activity", "Nuclease activity", "Nucleobase containing compound kinase activity", "Nucleobase containing compound transmembrane transporter activity", "Nucleobase transmembrane transporter activity", "Nucleocytoplasmic carrier activity", "Nucleoside binding", "Nucleoside diphosphatase activity", "Nucleoside diphosphate kinase activity", "Nucleoside kinase activity", "Nucleoside monophosphate kinase activity", "Nucleoside transmembrane transporter activity", "Nucleoside triphosphatase regulator activity", "Nucleoside triphosphate diphosphatase activity", "Nucleosomal dna binding", "Nucleosome binding", "Nucleotidase activity", "Nucleotide diphosphatase activity", "Nucleotide phosphatase activity acting on free nucleotides", "Nucleotide sugar transmembrane transporter activity", "Nucleotide transmembrane transporter activity", "Nucleotidyltransferase activity", "O acetyltransferase activity", "O acyltransferase activity", "O methyltransferase activity", "O palmitoyltransferase activity", "Oleate transmembrane transporter activity", "Oligopeptide binding", "Oligosaccharide binding", "Oligosaccharyl transferase activity", "Omega peptidase activity", "Opioid receptor binding", "Opsonin binding", "Organic acid binding", "Organic acid sodium symporter activity", "Organic acid transmembrane transporter activity", "Organic anion transmembrane transporter activity", "Organic cation transmembrane transporter activity", "Organic hydroxy compound transmembrane transporter activity", "Organophosphate ester transmembrane transporter activity", "Oxidative phosphorylation uncoupler activity", "Oxidative rna demethylase activity", "Oxidized dna binding", "Oxidoreductase activity", "Oxidoreductase activity acting on a heme group of donors", "Oxidoreductase activity acting on a sulfur group of donors", "Oxidoreductase activity acting on a sulfur group of donors disulfide as acceptor", "Oxidoreductase activity acting on a sulfur group of donors nad p as acceptor", "Oxidoreductase activity acting on a sulfur group of donors oxygen as acceptor", "Oxidoreductase activity acting on ch oh group of donors", "Oxidoreductase activity acting on ch or ch2 groups", "Oxidoreductase activity acting on diphenols and related substances as donors", "Oxidoreductase activity acting on nad p h", "Oxidoreductase activity acting on nad p h heme protein as acceptor", "Oxidoreductase activity acting on nad p h oxygen as acceptor", "Oxidoreductase activity acting on nad p h quinone or similar compound as acceptor", "Oxidoreductase activity acting on other nitrogenous compounds as donors", "Oxidoreductase activity acting on other nitrogenous compounds as donors cytochrome as acceptor", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced ascorbate as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced pteridine as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water", "Oxidoreductase activity acting on peroxide as acceptor", "Oxidoreductase activity acting on single donors with incorporation of molecular oxygen", "Oxidoreductase activity acting on the aldehyde or oxo group of donors", "Oxidoreductase activity acting on the aldehyde or oxo group of donors disulfide as acceptor", "Oxidoreductase activity acting on the aldehyde or oxo group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors", "Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors oxygen as acceptor", "Oxidoreductase activity acting on the ch nh group of donors", "Oxidoreductase activity acting on the ch nh group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch nh2 group of donors", "Oxidoreduction driven active transmembrane transporter activity", "Oxo acid lyase activity", "Oxygen binding", "Oxygen sensor activity", "Oxysterol binding", "P type calcium transporter activity", "P type potassium transmembrane transporter activity", "P type transmembrane transporter activity", "P53 binding", "Palmitoyl coa hydrolase activity", "Palmitoyl protein hydrolase activity", "Palmitoyltransferase activity", "Passive transmembrane transporter activity", "Patched binding", "Pattern recognition receptor activity", "Pdz domain binding", "Pentosyltransferase activity", "Peptidase activator activity", "Peptidase activator activity involved in apoptotic process", "Peptidase activity", "Peptidase regulator activity", "Peptide alpha n acetyltransferase activity", "Peptide antigen binding", "Peptide binding", "Peptide hormone binding", "Peptide hormone receptor binding", "Peptide lysine n acetyltransferase activity", "Peptide n acetyltransferase activity", "Peptide receptor activity", "Peptidoglycan binding", "Peptidyl proline 4 dioxygenase activity", "Peptidyl proline dioxygenase activity", "Peroxiredoxin activity", "Peroxisome proliferator activated receptor binding", "Peroxisome targeting sequence binding", "Phosphatase activator activity", "Phosphatase activity", "Phosphatase binding", "Phosphatase inhibitor activity", "Phosphatase regulator activity", "Phosphate ion binding", "Phosphatidic acid binding", "Phosphatidic acid transfer activity", "Phosphatidyl phospholipase b activity", "Phosphatidylcholine binding", "Phosphatidylcholine floppase activity", "Phosphatidylcholine transfer activity", "Phosphatidylcholine transporter activity", "Phosphatidylethanolamine binding", "Phosphatidylethanolamine flippase activity", "Phosphatidylglycerol binding", "Phosphatidylinositol 3 4 5 trisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate 5 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate binding", "Phosphatidylinositol 3 4 bisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate 5 phosphatase activity", "Phosphatidylinositol 3 5 bisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate phosphatase activity", "Phosphatidylinositol 3 kinase activity", "Phosphatidylinositol 3 kinase binding", "Phosphatidylinositol 3 kinase regulator activity", "Phosphatidylinositol 3 kinase regulatory subunit binding", "Phosphatidylinositol 3 phosphate binding", "Phosphatidylinositol 4 5 bisphosphate 3 kinase activity", "Phosphatidylinositol 4 5 bisphosphate 5 phosphatase activity", "Phosphatidylinositol 4 5 bisphosphate binding", "Phosphatidylinositol 4 5 bisphosphate phosphatase activity", "Phosphatidylinositol 4 phosphate binding", "Phosphatidylinositol 5 phosphate binding", "Phosphatidylinositol binding", "Phosphatidylinositol bisphosphate binding", "Phosphatidylinositol bisphosphate kinase activity", "Phosphatidylinositol bisphosphate phosphatase activity", "Phosphatidylinositol kinase activity", "Phosphatidylinositol monophosphate phosphatase activity", "Phosphatidylinositol phosphate 4 phosphatase activity", "Phosphatidylinositol phosphate 5 phosphatase activity", "Phosphatidylinositol phosphate binding", "Phosphatidylinositol phosphate kinase activity", "Phosphatidylinositol phosphate phosphatase activity", "Phosphatidylinositol transfer activity", "Phosphatidylinositol trisphosphate phosphatase activity", "Phosphatidylserine 1 acylhydrolase activity", "Phosphatidylserine binding", "Phosphodiesterase i activity", "Phosphofructokinase activity", "Phospholipase a1 activity", "Phospholipase a2 activity", "Phospholipase a2 inhibitor activity", "Phospholipase activity", "Phospholipase binding", "Phospholipase c activity", "Phospholipase d activity", "Phospholipase inhibitor activity", "Phospholipid binding", "Phospholipid scramblase activity", "Phospholipid transfer activity", "Phospholipid transporter activity", "Phosphoprotein binding", "Phosphoprotein phosphatase activity", "Phosphoric diester hydrolase activity", "Phosphoric ester hydrolase activity", "Phosphorus oxygen lyase activity", "Phosphoserine residue binding", "Phosphotransferase activity for other substituted phosphate groups", "Phosphotransferase activity nitrogenous group as acceptor", "Phosphotransferase activity phosphate group as acceptor", "Phosphotyrosine residue binding", "Plus end directed microtubule motor activity", "Poly a binding", "Poly a specific ribonuclease activity", "Poly g binding", "Poly purine tract binding", "Poly pyrimidine tract binding", "Polynucleotide adenylyltransferase activity", "Polypeptide n acetylgalactosaminyltransferase activity", "Polysaccharide binding", "Polysome binding", "Polyubiquitin modification dependent protein binding", "Porin activity", "Potassium channel inhibitor activity", "Potassium channel regulator activity", "Potassium chloride symporter activity", "Potassium ion binding", "Potassium ion transmembrane transporter activity", "Pre mirna binding", "Pre mrna 3 splice site binding", "Pre mrna 5 splice site binding", "Pre mrna binding", "Pre mrna intronic binding", "Prenyltransferase activity", "Primary active transmembrane transporter activity", "Primary mirna binding", "Procollagen proline 4 dioxygenase activity", "Procollagen proline dioxygenase activity", "Profilin binding", "Proline rich region binding", "Promoter specific chromatin binding", "Protease binding", "Proteasome activating activity", "Proteasome binding", "Protein adp ribosylase activity", "Protein antigen binding", "Protein arginine n methyltransferase activity", "Protein arginine omega n asymmetric methyltransferase activity", "Protein arginine omega n monomethyltransferase activity", "Protein binding involved in heterotypic cell cell adhesion", "Protein c terminus binding", "Protein carboxyl o methyltransferase activity", "Protein carrier chaperone", "Protein containing complex binding", "Protein cysteine s stearoyltransferase activity", "Protein deacetylase activity", "Protein demethylase activity", "Protein dimerization activity", "Protein disaggregase activity", "Protein disulfide isomerase activity", "Protein disulfide reductase nad p activity", "Protein domain specific binding", "Protein folding chaperone", "Protein geranylgeranyltransferase activity", "Protein heterodimerization activity", "Protein homodimerization activity", "Protein kinase a binding", "Protein kinase a catalytic subunit binding", "Protein kinase a regulatory subunit binding", "Protein kinase activity", "Protein kinase b binding", "Protein kinase c activity", "Protein kinase c binding", "Protein lipid complex binding", "Protein macromolecule adaptor activity", "Protein membrane adaptor activity", "Protein methyltransferase activity", "Protein n terminus binding", "Protein phosphatase 1 binding", "Protein phosphatase 2a binding", "Protein phosphatase 2b binding", "Protein phosphatase activator activity", "Protein phosphatase binding", "Protein phosphatase regulator activity", "Protein phosphorylated amino acid binding", "Protein prenyltransferase activity", "Protein self association", "Protein serine kinase activity", "Protein serine threonine kinase activator activity", "Protein serine threonine kinase activity", "Protein serine threonine kinase inhibitor activity", "Protein serine threonine phosphatase activity", "Protein serine threonine phosphatase inhibitor activity", "Protein serine threonine tyrosine kinase activity", "Protein tag", "Protein transmembrane transporter activity", "Protein transporter activity", "Protein tyrosine kinase activator activity", "Protein tyrosine kinase activity", "Protein tyrosine kinase binding", "Protein tyrosine kinase inhibitor activity", "Protein tyrosine phosphatase activity", "Protein tyrosine serine threonine phosphatase activity", "Protein tyrosine threonine phosphatase activity", "Proteoglycan binding", "Proton channel activity", "Proton transmembrane transporter activity", "Proton transporting atp synthase activity rotational mechanism", "Pseudouridine synthase activity", "Purine nucleotide transmembrane transporter activity", "Pyrimidine nucleoside transmembrane transporter activity", "Pyrimidine nucleotide binding", "Pyrimidine nucleotide sugar transmembrane transporter activity", "Pyrophosphate hydrolysis driven proton transmembrane transporter activity", "Pyruvate dehydrogenase acetyl transferring kinase activity", "Pyruvate dehydrogenase activity", "Pyruvate transmembrane transporter activity", "Quaternary ammonium group binding", "Quaternary ammonium group transmembrane transporter activity", "Quinone binding", "R smad binding", "Racemase and epimerase activity", "Rage receptor binding", "Rdna binding", "Receptor antagonist activity", "Receptor tyrosine kinase binding", "Regulatory rna binding", "Retinal binding", "Retinal dehydrogenase activity", "Retinoic acid binding", "Retinoic acid receptor binding", "Retinoid x receptor binding", "Retinol binding", "Retromer complex binding", "Ribonuclease activity", "Ribonuclease p activity", "Ribonuclease p rna binding", "Ribonucleoprotein complex binding", "Ribonucleotide binding", "Ribose phosphate diphosphokinase activity", "Ribosomal large subunit binding", "Ribosomal protein s6 kinase activity", "Ribosomal small subunit binding", "Ribosome binding", "Rna 2 o methyltransferase activity", "Rna 7 methylguanosine cap binding", "Rna adenylyltransferase activity", "Rna binding", "Rna binding involved in posttranscriptional gene silencing", "Rna cap binding", "Rna directed dna polymerase activity", "Rna dna hybrid ribonuclease activity", "Rna methyltransferase activity", "Rna polymerase activity", "Rna polymerase binding", "Rna polymerase core enzyme binding", "Rna polymerase i general transcription initiation factor activity", "Rna polymerase i transcription regulatory region sequence specific dna binding", "Rna polymerase ii activity", "Rna polymerase ii c terminal domain binding", "Rna polymerase ii c terminal domain phosphoserine binding", "Rna polymerase ii core promoter sequence specific dna binding", "Rna polymerase ii ctd heptapeptide repeat kinase activity", "Rna polymerase ii general transcription initiation factor activity", "Rna polymerase ii general transcription initiation factor binding", "Rna polymerase ii specific dna binding transcription factor binding", "Rna polymerase iii transcription regulatory region sequence specific dna binding", "Rna stem loop binding", "Rna strand annealing activity", "Roundabout binding", "Rrna adenine methyltransferase activity", "Rrna binding", "Rrna cytosine methyltransferase activity", "S acyltransferase activity", "S adenosyl l methionine binding", "S adenosylmethionine dependent methyltransferase activity", "S methyltransferase activity", "S100 protein binding", "Scaffold protein binding", "Scavenger receptor activity", "Secondary active transmembrane transporter activity", "Semaphorin receptor activity", "Sequence specific dna binding", "Sequence specific mrna binding", "Sequence specific single stranded dna binding", "Serine hydrolase activity", "Serine transmembrane transporter activity", "Serine type carboxypeptidase activity", "Serine type endopeptidase inhibitor activity", "Serine type exopeptidase activity", "Sh2 domain binding", "Sh3 domain binding", "Sialyltransferase activity", "Signal recognition particle binding", "Signal sequence binding", "Signaling adaptor activity", "Signaling receptor binding", "Signaling receptor complex adaptor activity", "Signaling receptor inhibitor activity", "Signaling receptor regulator activity", "Single stranded dna 3 5 exodeoxyribonuclease activity", "Single stranded dna binding", "Single stranded dna endodeoxyribonuclease activity", "Single stranded dna exodeoxyribonuclease activity", "Single stranded dna helicase activity", "Single stranded rna binding", "Single stranded telomeric dna binding", "Sirna binding", "Smad binding", "Small molecule sensor activity", "Small protein activating enzyme binding", "Small ribosomal subunit rrna binding", "Snap receptor activity", "Snare binding", "Snorna binding", "Snrna binding", "Snrnp binding", "Sodium channel inhibitor activity", "Sodium channel regulator activity", "Sodium chloride symporter activity", "Sodium ion binding", "Sodium ion transmembrane transporter activity", "Solute anion antiporter activity", "Solute bicarbonate symporter activity", "Solute cation antiporter activity", "Solute cation symporter activity", "Solute proton antiporter activity", "Solute proton symporter activity", "Solute sodium symporter activity", "Spectrin binding", "Sphingolipid binding", "Sphingolipid transfer activity", "Sphingolipid transporter activity", "Sphingomyelin phosphodiesterase activity", "Steroid binding", "Steroid dehydrogenase activity", "Steroid dehydrogenase activity acting on the ch oh group of donors nad or nadp as acceptor", "Steroid hormone binding", "Sterol binding", "Sterol esterase activity", "Sterol transfer activity", "Sterol transporter activity", "Structural constituent of cytoskeleton", "Structural constituent of eye lens", "Structural constituent of muscle", "Structural constituent of nuclear pore", "Structural constituent of postsynapse", "Structural constituent of postsynaptic actin cytoskeleton", "Structural constituent of presynaptic active zone", "Structural constituent of ribosome", "Structural constituent of synapse", "Structural molecule activity", "Structural molecule activity conferring elasticity", "Succinate transmembrane transporter activity", "Sugar transmembrane transporter activity", "Sulfate binding", "Sulfate transmembrane transporter activity", "Sulfatide binding", "Sulfotransferase activity", "Sulfur compound binding", "Sulfur compound transmembrane transporter activity", "Sulfuric ester hydrolase activity", "Sulfurtransferase activity", "Sumo binding", "Sumo ligase activity", "Sumo specific protease activity", "Sumo transferase activity", "Supercoiled dna binding", "Superoxide dismutase activity", "Symporter activity", "Syndecan binding", "Syntaxin 1 binding", "Syntaxin binding", "T cell receptor binding", "Tap binding", "Tat protein binding", "Tau protein binding", "Tau protein kinase activity", "Tbp class protein binding", "Telomerase activity", "Telomerase inhibitor activity", "Telomerase rna binding", "Telomeric dna binding", "Testosterone dehydrogenase nad p activity", "Testosterone dehydrogenase nadplus activity", "Tetrapyrrole binding", "Tfiib class transcription factor binding", "Tfiid class transcription factor complex binding", "Thiamine pyrophosphate binding", "Thioesterase binding", "Thiol oxidase activity", "Thiolester hydrolase activity", "Thioredoxin disulfide reductase activity", "Threonine type endopeptidase activity", "Threonine type peptidase activity", "Thyroid hormone receptor binding", "Titin binding", "Toll like receptor binding", "Toxic substance binding", "Tpr domain binding", "Transcription coactivator activity", "Transcription coactivator binding", "Transcription coregulator activity", "Transcription coregulator binding", "Transcription corepressor activity", "Transcription corepressor binding", "Transcription elongation regulator activity", "Transcription factor binding", "Transcription regulator activity", "Transcription regulator inhibitor activity", "Transferase activity transferring alkyl or aryl other than methyl groups", "Transferase activity transferring nitrogenous groups", "Transferase activity transferring one carbon groups", "Transferase activity transferring phosphorus containing groups", "Transferase activity transferring sulphur containing groups", "Transferrin receptor binding", "Transforming growth factor beta binding", "Transforming growth factor beta receptor binding", "Transition metal ion binding", "Transition metal ion transmembrane transporter activity", "Transketolase or transaldolase activity", "Translation activator activity", "Translation elongation factor activity", "Translation factor activity rna binding", "Translation initiation factor activity", "Translation initiation factor binding", "Translation regulator activity", "Translation regulator activity nucleic acid binding", "Translation repressor activity", "Translation repressor activity mrna regulatory element binding", "Translation termination factor activity", "Transmembrane receptor protein kinase activity", "Transmembrane receptor protein phosphatase activity", "Transmembrane receptor protein tyrosine kinase activity", "Transmembrane transporter binding", "Transporter activity", "Triglyceride lipase activity", "Trna binding", "Trna cytosine methyltransferase activity", "Trna guanine methyltransferase activity", "Trna methyltransferase activity", "Trna specific adenosine deaminase activity", "Trna specific ribonuclease activity", "Tropomyosin binding", "Tubulin binding", "Tumor necrosis factor activated receptor activity", "Tumor necrosis factor receptor binding", "Tumor necrosis factor receptor superfamily binding", "Type i transforming growth factor beta receptor binding", "U1 snrna binding", "U2 snrna binding", "U3 snorna binding", "U4 snrna binding", "U6 snrna binding", "Ubiquinol cytochrome c reductase activity", "Ubiquinone binding", "Ubiquitin binding", "Ubiquitin conjugating enzyme binding", "Ubiquitin ligase substrate adaptor activity", "Ubiquitin like modifier activating enzyme activity", "Ubiquitin like protein binding", "Ubiquitin like protein conjugating enzyme activity", "Ubiquitin like protein conjugating enzyme binding", "Ubiquitin like protein ligase activity", "Ubiquitin like protein ligase binding", "Ubiquitin like protein specific isopeptidase activity", "Ubiquitin like protein specific protease activity", "Ubiquitin like protein transferase activity", "Ubiquitin protein transferase activator activity", "Ubiquitin protein transferase inhibitor activity", "Ubiquitin protein transferase regulator activity", "Ubiquitin specific protease binding", "Ubiquitin ubiquitin ligase activity", "Ubiquitination like modification dependent protein binding", "Udp galactose beta n acetylglucosamine beta 1 3 galactosyltransferase activity", "Udp glucosyltransferase activity", "Udp glycosyltransferase activity", "Udp xylosyltransferase activity", "Unfolded protein binding", "Unmethylated cpg binding", "Uridine transmembrane transporter activity", "Uridylyltransferase activity", "Vascular endothelial growth factor activated receptor activity", "Vascular endothelial growth factor binding", "Vascular endothelial growth factor receptor 2 binding", "Vascular endothelial growth factor receptor binding", "Very long chain fatty acid coa ligase activity", "Vinculin binding", "Virion binding", "Vitamin b6 binding", "Vitamin binding", "Vitamin d binding", "Vitamin d receptor binding", "Vitamin transmembrane transporter activity", "Voltage gated anion channel activity", "Voltage gated calcium channel activity", "Voltage gated calcium channel activity involved in regulation of cytosolic calcium levels", "Voltage gated cation channel activity", "Voltage gated channel activity", "Voltage gated chloride channel activity", "Volume sensitive anion channel activity", "Water channel activity", "Water transmembrane transporter activity", "Wd40 repeat domain binding", "Wide pore channel activity", "Ww domain binding", "Xenobiotic transmembrane transporter activity", "Zinc ion binding", "Zinc ion transmembrane transporter activity"], "available_proteins": ["AAMP", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGFG1", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALG9", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD13A", "ANLN", "ANO10", "ANO6", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3M1", "APC", "APEH", "APEX1", "API5", "APMAP", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARG2", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID4B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARL6", "ARL6IP1", "ARL8B", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC1", "ASCC2", "ASCC3", "ASF1A", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATG13", "ATG3", "ATG4B", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATP7B", "ATPIF1", "ATXN2", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BABAM2", "BAG2", "BAG5", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BCAP31", "BCCIP", "BCKDK", "BCL10", "BCL2L13", "BCLAF1", "BCS1L", "BEND3", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BRAP", "BRCA1", "BRD1", "BRD2", "BRD3", "BRD4", "BRD7", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C1QBP", "C1orf123", "C1orf35", "C2CD5", "C7orf50", "CAB39", "CACYBP", "CAD", "CALCOCO1", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAMSAP3", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CC2D1A", "CCAR1", "CCAR2", "CCDC124", "CCDC22", "CCDC47", "CCDC6", "CCDC86", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD276", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK16", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK5RAP2", "CDK5RAP3", "CDK7", "CDK9", "CDKAL1", "CDKN2AIP", "CDR2L", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPV", "CEP290", "CEP44", "CETN2", "CFAP20", "CFL1", "CFL2", "CGGBP1", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHEK2", "CHERP", "CHID1", "CHKA", "CHMP1A", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHORDC1", "CHP1", "CHRAC1", "CHST14", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CIZ1", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT7", "CNOT9", "CNP", "COASY", "COIL", "COLEC12", "COLGALT1", "COMMD1", "COMMD7", "COMT", "COMTD1", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS4", "COPS5", "COPS6", "COQ8A", "CORO1C", "COTL1", "COX11", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX7A2", "COX7A2L", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK1E", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CTTNBP2NL", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUL7", "CUTA", "CWF19L1", "CXADR", "CXorf57", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAG1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCP1B", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D5", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DERL1", "DFFA", "DGCR8", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DR1", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUS2", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EEFSEC", "EFHD2", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHHADH", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC3", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC3", "ERCC6L", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC4", "EXOC5", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAHD1", "FAM120A", "FAM129B", "FAM208A", "FAM213A", "FAM3C", "FAM49B", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD2", "FAU", "FBL", "FBXO22", "FBXO7", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FKRP", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FNBP1", "FNDC3A", "FNTA", "FNTB", "FOXK1", "FOXK2", "FOXRED1", "FRG1", "FSCN1", "FTL", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCLC", "GCN1", "GDE1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GGH", "GGPS1", "GHDC", "GID4", "GIGYF2", "GIPC1", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLTP", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAO1", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLPH3", "GOSR1", "GOSR2", "GOT1", "GOT2", "GPAT4", "GPATCH4", "GPATCH8", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR89B", "GPRASP2", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2H4", "GTF2I", "GTF3C4", "GTPBP1", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD2", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAT1", "HAUS4", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCR", "HMGCS1", "HMGN1", "HMGXB4", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IFT88", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKG", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INCENP", "INF2", "INPP4A", "INTS11", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "IRF2BPL", "IRGQ", "IRS4", "ISCU", "IST1", "ISYNA1", "ITGAV", "ITGB1", "ITPA", "ITPRIP", "IVD", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0368", "KIAA0391", "KIF11", "KIF14", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KNOP1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LCMT2", "LDAH", "LDB1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC59", "LRRC8C", "LRWD1", "LSM14B", "LSM2", "LSM4", "LSM6", "LSS", "LTA4H", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LYPLA2", "LZIC", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGT1", "MAIP1", "MAK16", "MAN1A1", "MAN1A2", "MAN2A1", "MANF", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARK2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED16", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METAP2", "METTL1", "METTL13", "METTL3", "MFAP1", "MFF", "MFN2", "MFSD10", "MFSD5", "MFSD8", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIEF1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMGT1", "MMS19", "MOGS", "MORC2", "MORF4L1", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPRIP", "MPST", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL27", "MRPL3", "MRPL33", "MRPL37", "MRPL39", "MRPL4", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL49", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS17", "MRPS2", "MRPS21", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSI2", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTOR", "MTPAP", "MTPN", "MTR", "MUT", "MVD", "MYBBP1A", "MYCBP", "MYCBP2", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAF1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCOR1", "NCSTN", "ND5", "NDC1", "NDUFA10", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS5", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFB", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NF1", "NFRKB", "NFS1", "NFXL1", "NHP2", "NIFK", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP10", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRP1", "NSA2", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTPCR", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD2", "NUDCD3", "NUDT1", "NUDT16L1", "NUDT19", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP35", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OMA1", "OPA1", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP2", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARL", "PARN", "PARP1", "PARP2", "PBK", "PBRM1", "PBXIP1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCM1", "PCMT1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDSS2", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PHAX", "PHB", "PHB2", "PHC2", "PHF10", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHPT1", "PI4K2A", "PI4KA", "PICALM", "PIGG", "PIGK", "PIH1D1", "PIK3C2A", "PIK3R2", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "POFUT1", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLE4", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR2L", "POLR3A", "POLR3C", "POLR3E", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPHLN1", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R14B", "PPP1R9B", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRELID3B", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSME1", "PSME2", "PSME3", "PSMG1", "PSMG3", "PSPC1", "PSPH", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PTRHD1", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RABAC1", "RABEP1", "RABGAP1", "RABGEF1", "RABGGTA", "RABL3", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALGAPB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANGAP1", "RAP1GDS1", "RAP2B", "RAPGEF2", "RARS", "RASA1", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM47", "RBM5", "RBM6", "RBM7", "RBM8A", "RBMX", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REPS1", "RER1", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT2", "RIDA", "RIOK2", "RIPK1", "RMDN1", "RMDN3", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF219", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPA3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS27", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RTCA", "RTCB", "RTF1", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SBNO1", "SC5D", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP3", "SCAP", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SCRN3", "SCYL2", "SDCBP", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC13", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHCBP1", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIN3A", "SIN3B", "SIRT1", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC2A8", "SLC30A5", "SLC30A9", "SLC35A4", "SLC35B2", "SLC35F2", "SLC38A1", "SLC39A14", "SLC3A2", "SLC44A1", "SLC4A1AP", "SLC4A7", "SLC7A1", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNIP1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX2", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC24", "SPCS2", "SPCS3", "SPDL1", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRFBP1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "ST3GAL4", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK26", "STK38", "STK4", "STMN1", "STOML2", "STRAP", "STRBP", "STRIP1", "STRN", "STT3A", "STT3B", "STUB1", "STX10", "STX12", "STX18", "STX4", "STX5", "STX6", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUMF2", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYNCRIP", "SYNE1", "SYNE2", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TARDBP", "TARS", "TARS2", "TARSL2", "TAX1BP1", "TBC1D10A", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDP2", "TECR", "TEFM", "TELO2", "TERF2IP", "TES", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THTPA", "THUMPD1", "THUMPD3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM13", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TJP1", "TJP2", "TK1", "TKFC", "TKT", "TLN1", "TLN2", "TMBIM6", "TMCO1", "TMED10", "TMED9", "TMEM109", "TMEM192", "TMEM201", "TMEM43", "TMEM70", "TMF1", "TMLHE", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TNKS1BP1", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1A", "TOR1AIP1", "TOR1AIP2", "TOR1B", "TP53", "TP53BP1", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRIM13", "TRIM21", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIO", "TRIP10", "TRIP12", "TRIP13", "TRIP4", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSC2", "TSFM", "TSG101", "TSNAX", "TSPO", "TSPYL1", "TSR1", "TSR3", "TTC1", "TTC26", "TTC4", "TTF2", "TTK", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBG1", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAP2", "UBAP2L", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBL5", "UBLCP1", "UBP1", "UBQLN2", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN1", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UFSP2", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF3B", "UQCR10", "UQCRC1", "UQCRC2", "UQCRFS1", "URB1", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP28", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VEZT", "VIM", "VIRMA", "VKORC1L1", "VMP1", "VPS16", "VPS18", "VPS25", "VPS33B", "VPS35", "VPS37B", "VPS4A", "VPS4B", "VRK1", "VRK3", "WARS", "WARS2", "WBP11", "WBP2", "WDR1", "WDR12", "WDR3", "WDR36", "WDR4", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR75", "WDR77", "WDR82", "WFS1", "WIPI2", "WIZ", "WRAP53", "WTAP", "XPA", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDF2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3H7B", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZDHHC6", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZNF207", "ZNF281", "ZNF318", "ZNF326", "ZNF512B", "ZNF598", "ZNF638", "ZPR1", "ZW10", "ZYX", "ZZZ3"], "leading_proteins": ["ABCB1", "ABCB7", "ABCD3", "ABHD10", "ACADVL", "ACAT2", "ACOX1", "ACP2", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ADA", "ADI1", "AFG3L2", "AGPAT5", "AGPS", "AHSA1", "AIFM1", "AKAP8L", "ALDH1B1", "ALDH3A2", "ALG1", "ALG12", "ALG9", "ANAPC2", "ANKLE2", "ANO10", "ANO6", "ANXA7", "APC", "ARHGEF7", "ASAH1", "ASNA1", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5B", "ATP5F1", "ATP5H", "ATP5I", "ATP5L", "ATP6", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V1E1", "ATP7A", "ATP7B", "B3GALT6", "B4GAT1", "BAIAP2", "BCAP31", "BICD2", "BNIP1", "BOLA2*", "BSG", "CALD1", "CALU", "CANX", "CCDC47", "CCDC6", "CD47", "CDIPT", "CDK5RAP2", "CDKAL1", "CETN2", "CHKA", "CIRBP", "CISD1", "CLCN3", "CLN5", "CLPP", "CNNM4", "CNOT9", "COMMD1", "COMT", "COPS4", "COX11", "COX15", "COX2", "COX4I1", "COX5A", "COX7A2", "CPD", "CPT1A", "CPT2", "CPVL", "CRK", "CRTAP", "CTNNA1", "CTSA", "CXADR", "CYB5B", "CYP20A1", "CYP51A1", "DAG1", "DAGLB", "DDX3X", "DERL1", "DHCR24", "DHFR", "DHODH", "DLD", "DNAJC1", "DNAJC10", "DNAJC3", "DOHH", "DYNC1LI1", "ECD", "ECE1", "EHD1", "EHD4", "EIF4B", "EIF4H", "EIF6", "EMC2", "EMC7", "EPB41L3", "EPDR1", "EPHA7", "ERAP1", "ERGIC3", "ERLIN1", "ERLIN2", "ERO1A", "ETFDH", "FADS2", "FAF2", "FAM3C", "FDFT1", "FDPS", "FECH", "FKBP14", "FKBP4", "FLOT1", "FNBP1", "FTL", "FUCA1", "FUCA2", "FUNDC2", "FXR1", "GAA", "GALNT1", "GBA", "GDE1", "GGCX", "GGH", "GGPS1", "GLA", "GLB1", "GLTP", "GM2A", "GNAI1", "GNAI2", "GNAO1", "GNS", "GOLPH3", "GOSR1", "GPD2", "GPR89B", "GRB2", "GTF2E1", "GUSB", "GYS1", "HEXA", "HK2", "HLA-A", "HLA-C", "HM13", "HMCES", "HMGB1", "HMGB2", "HMGCR", "HMOX1", "HMOX2", "HNRNPA2B1", "HNRNPC", "HS2ST1", "HSD17B12", "HSDL1", "HSPA13", "IGF2R", "ILVBL", "IMPAD1", "INA", "IRS4", "ITGB1", "KDELC2", "KDELR1", "KDM1B", "KPNA2", "LAMP1", "LBR", "LDAH", "LETM1", "LGALS3", "LGALS3BP", "LIPA", "LMAN2", "LNPEP", "LPCAT1", "LRRC8C", "LTA4H", "M6PR", "MAGT1", "MAN1A2", "MATR3", "MBOAT7", "MCL1", "MCU", "MFSD10", "MGST2", "MIA3", "MICU1", "MICU2", "MMAB", "MMGT1", "MPC2", "MPP1", "MPP2", "MRC2", "MSMO1", "MTCH1", "MTR", "NAGLU", "NAMPT", "NCLN", "NCSTN", "NDC1", "NDUFA13", "NDUFA4", "NDUFB10", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS2", "NEFL", "NEFM", "NENF", "NNT", "NPC1", "NPEPPS", "NT5C3B", "NUCB1", "NUCB2", "NUDT1", "NUP35", "OCRL", "OLA1", "OMA1", "OPA1", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HB", "PARL", "PCYOX1", "PDCL3", "PDK1", "PDK3", "PECR", "PEF1", "PEX19", "PFDN6", "PGRMC1", "PHB2", "PI4K2A", "PIGK", "PIH1D1", "PITRM1", "PLA2G15", "PLBD2", "PLD3", "PLXNB2", "PM20D2", "PMPCA", "PON2", "POR", "PPT1", "PPT2", "PRCP", "PREPL", "PRKAR1A", "PRKAR2A", "PRRC1", "PSMB2", "PSMB5", "PSMB6", "PSME2", "PSME3", "PTDSS2", "PTGES2", "PTGR2", "PTPN1", "QSOX2", "RAB10", "RAB11B", "RABAC1", "RACGAP1", "RAPGEF2", "RASA1", "RBM10", "RBM3", "RBM4", "RBM7", "RCN1", "RCN2", "RDH13", "REPS1", "RIDA", "RIPK1", "RNF40", "S100A13", "SACM1L", "SC5D", "SCAP", "SCARB1", "SCARB2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SDCBP", "SDF4", "SDHB", "SEC22B", "SEC62", "SEC63", "SFXN1", "SFXN2", "SFXN4", "SGTA", "SH3GLB1", "SIGMAR1", "SIRT2", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", 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0.0692932819421307 0.0056014850653733 0.0050558292110143 +Optic neuropathy 7 22 2.622901820938025 0.0087184392227985 6.834951456310679 22.009708737864077 0.7947386425872367 0.3403162177193031 3.144874354625535 3.3508299091739815 1.3090216253320466 0.3062511530983536 0.000497203887235 1.0 0.0108939889611676 1.6783269894967037e-05 0.0004290006789134 +Clumsiness 9 22 2.620264722404618 0.0087861533935762 6.75 20.57766990291262 0.9027704056640264 0.2559090219975202 2.4698423753801175 2.2221930931993956 1.527926415027724 0.282470536898918 0.0005742307227979 0.0221752921749746 0.0115248505447769 0.0063027604866002 9.85983881561296e-05 +Action tremor 20 55 2.577546316949997 0.0099504545232438 13.143203883495143 54.47572815533981 1.1235280535029035 0.3645421720231636 5.4627047451961745 5.814853194507433 1.1817578847970691 0.3688885139588422 0.0331279238978814 0.0235514080322567 0.0084980050977086 0.0391925104047672 0.0016801748699389 +Hyperintensity of cerebral white matter on mri 8 17 2.568497242448847 0.0102140524798193 5.844660194174757 19.76456310679612 0.5239793769920946 0.3497882694217939 2.383223245915457 2.1845455756818453 1.3844482033830876 0.3203944687906004 0.0078294251515635 1.0 0.0693457394610891 0.0227330174276438 0.0002580266226921 +Sensorimotor neuropathy 11 30 2.566517984787012 0.0102725298018959 8.980582524271844 31.118932038834952 1.3016328701661894 0.3009249972125085 3.646997920951252 3.5836645053134393 1.2437208862143418 0.3260038325488978 0.0015692063317428 0.2821140734917597 0.029653655190088 0.00143626842716 0.0019108778393583 +Ragged red muscle fibers 9 19 2.553450043547297 0.0106661578260949 5.233009708737864 17.730582524271846 1.450228655394427 0.2143723456093393 2.356374883616516 2.3878203593303375 1.2019998086948689 0.268108115907532 0.0038189986913047 0.1683799151698467 0.0061250241039257 0.0023124348467711 0.0105883475769395 +Ectopic calcification 17 57 2.5368843186516346 0.0111843905243935 13.553398058252426 56.53155339805825 0.5275931647443897 0.4410566614950294 4.995100814049753 5.994858194438004 1.2985638579898735 0.3743313818119885 6.664550273134761e-05 1.0 0.4176554250980517 0.286330031083999 0.0002882025351099 +Progressive neurologic deterioration 9 19 2.507816294299149 0.0121479805422757 6.75 20.466019417475728 0.5813429756502071 0.2930928839947513 2.6727908035631316 1.300228015706032 1.5791549964390388 0.3142214461904322 0.0002267746326666 1.0 0.3404254693467198 6.706147432458563e-05 2.990302515741305e-05 +Dysostosis multiplex 5 7 2.477920584172689 0.0132150555645849 3.983009708737864 7.990291262135922 0.4150973501220912 0.1595724105588133 1.65382835361071 1.246316090990369 1.8479195153421644 0.2123242141003258 0.0001153529633139 1.0 0.1837383274168749 0.0014320459890063 0.0003689915939861 +Abnormality of the ribs 22 64 2.465178269640592 0.0136945098298952 15.46359223300971 63.26456310679612 0.6596881680500318 0.4822792711086646 5.162987649103379 7.327989071924885 1.0464354559452582 0.3722680363619953 0.0010990488369605 1.0 0.312508620554065 0.0588745965413039 0.0048496715602896 +Retinal degeneration 11 54 2.4638532869528724 0.013745236138339 11.890776699029129 56.16747572815534 0.249024006789609 0.518990175786131 4.729602333356375 6.268553853518324 1.1275766261124216 0.3578686327011649 0.0706400832685727 0.0019062907229164 0.0023173406020662 0.0891710179820889 0.2129411032214198 +Abnormal csf metabolite level 14 59 2.4472252493926128 0.0143960837950356 15.62864077669903 56.38834951456311 0.3728365451013375 0.4594620050205593 7.183479908053284 5.909073177714687 1.318852118504194 0.3560984107552507 1.712276701159247e-05 0.3980408639782044 0.0036338339198907 9.691804675086625e-06 5.399943600117159e-05 +Respiratory arrest 3 9 2.4377415569538825 0.0147793361590695 2.0558252427184467 7.070388349514563 1.3186130117670736 0.2232983865916446 1.389730031946098 1.4320861436977392 0.8270726521635177 0.2287950263954721 0.0046090980714051 1.0 1.0 0.0688460117016781 0.0097510399506001 +Fluctuations in consciousness 4 8 2.436903717690531 0.0148136230895121 2.871359223300971 7.104368932038835 1.0899440920546752 0.2545542015295898 1.680977263462837 1.481694234866534 1.1451509420956862 0.2733842157028129 0.0006679426562608 1.0 0.1677870330809631 0.0757571260003459 0.0017429018144962 +Abnormality of femur morphology 20 66 2.43463197149788 0.0149069427934269 17.20873786407767 66.68203883495146 0.8363246416857221 0.4265359075043799 5.791282481104246 7.777760660479065 1.2398669594969238 0.3848538433547022 0.000233000791669 0.6050764268871254 0.5625214087730925 0.0076342271333758 0.0005029678292426 +Disproportionate short limb short stature 7 20 2.434158524412424 0.0149264563364044 6.587378640776699 19.902912621359224 1.344701363676014 0.2682000023842777 2.8599402401133336 3.1206003999939886 0.9439707190715964 0.2973700803613334 0.0168066225602795 0.2752604452820565 0.4825947600252522 0.2256891642594976 0.0166822263622692 +Increased csf lactate 14 53 2.433032756838991 0.0149729462513292 14.563106796116504 50.03398058252427 0.4527108683296134 0.4236743568986457 6.839235611227043 5.521257303659666 1.4241114192986506 0.3526497741057939 1.6521915413534831e-06 0.344137720202208 0.0016245798886056 1.3626218603682728e-06 4.931605069960055e-06 +Polyneuropathy 8 21 2.4240597081831945 0.0153480818085611 5.689320388349515 18.633495145631063 1.1475655107151586 0.297256939859202 2.871111980426299 2.8359934163787166 1.1251440285742276 0.3008764483611514 0.0001653185965902 1.0 0.3955810682553247 0.0081044088621321 0.0007920809146458 +Pathologic fracture 6 15 2.404790889605685 0.0161817221352993 4.257281553398058 15.072815533980584 0.983166532607372 0.3143076297274698 2.133145812327421 2.2800397788540345 1.0713003315034937 0.2893419439464214 0.0038189986913047 0.1683799151698467 0.3143397790261298 0.6149168035506691 0.0105883475769395 +Ventricular hypertrophy 14 40 2.396250512104787 0.016563765374161 10.04126213592233 36.45873786407767 1.1361758135608295 0.3518404639351837 4.440080726024568 4.153106961798495 1.0569836433105884 0.3376234863759063 0.0003233636451175 1.0 0.2319888267069046 0.0794624934300223 0.0020813334663892 +Abnormal macrophage morphology 3 5 2.3835975395652733 0.0171443404386997 2.9150485436893203 5.640776699029126 -0.1129741045260028 0.144980672561322 1.3090672390975422 1.117854819168669 1.9286041303300476 0.1913667515871486 0.002916997936102 0.0727733471903131 0.1432798584585485 0.0004788146962384 0.0062633876942655 +Exercise intolerance 7 35 2.382452206076574 0.0171977642344993 7.589805825242719 32.94660194174757 0.6935647402019111 0.4794430320014746 3.6422804337959303 3.649320073231373 0.9787082553108852 0.3464451860868903 0.0082054680151028 0.0473022522201117 0.034172513126223 0.0003907769995998 0.0264828345654996 +Exaggerated startle response 2 8 2.380753099719507 0.0172772876355133 2.987864077669903 8.699029126213592 0.0610274034602423 0.2634753902852135 1.4337635656228835 1.0620090089420118 1.617556501702403 0.2831541938798349 0.0191851660395208 1.0 0.1349531130589082 0.0495157384890535 0.0334620993119388 +Foam cells 4 6 2.378095314265793 0.0174023270195309 2.9611650485436893 5.398058252427185 -0.064606162326146 0.1366553329191208 1.1817572081322671 0.893230265545378 1.9405286208577948 0.1862104272675829 4.6039124814958446e-06 0.0370595951599339 0.0743799864466655 2.1451255431067108e-05 1.3106068439724131e-05 +Arteriosclerosis 6 12 2.3679940707210165 0.0178848225219641 4.885922330097087 14.944174757281552 0.0721468675738393 0.2032976413320727 1.852339343238996 2.0572604199467093 1.788928597657784 0.2405012300780825 0.0024861818192233 0.2031027035797352 0.0775813155228076 0.0057706709278987 0.0079620077053278 +Decreased activity of mitochondrial complex iv 3 17 2.3677866548202684 0.0178948515353465 3.878640776699029 15.9247572815534 0.8034271187166634 0.3445303465767608 2.844656052218728 1.5238137800378977 1.1422119451186783 0.2970372577525856 0.0226697205376047 0.0075879492488378 0.0023694947377154 0.0042924995678 0.0446088038944012 +Abnormal epiphyseal ossification 8 16 2.363718141453353 0.0180925716678714 6.451456310679611 16.274271844660195 1.1227269321938518 0.3276999393402902 3.140724178369711 2.4155680760400804 1.043634905787503 0.3148370578580727 0.001480117718684 1.0 1.0 0.6593533907576883 0.0002155385692345 +Abnormal tissue metabolite concentration 8 12 2.356228196314249 0.0184615726853061 5.895631067961165 14.650485436893204 0.4799987914691458 0.2340469593783387 2.3926019349714145 2.328417679576543 1.7567023743300048 0.2768423789344761 0.0015802568545913 1.0 0.2732850813359189 0.0078094686864188 0.0001380057592112 +Diarrhea 17 71 2.335130877097729 0.0195365847421584 15.235436893203884 71.36893203883496 -0.0937123546508902 0.4891141680274506 5.321271341758422 8.34189367719314 1.2527606286184891 0.3588826008598239 0.0015283332412626 0.6325910777230552 0.1434578911288594 0.0049085935904814 0.0136567371586889 +Abnormality of the wrist 10 30 2.326311363741058 0.0200019462380542 6.95873786407767 30.155339805825243 0.4893391061224179 0.4739542714047036 3.2628753712893035 4.83666675230799 1.0000289125440789 0.3174741185520122 0.0012982552645347 0.3656394840654732 0.0648989212296417 0.0822680536417182 0.0066637592153144 +Muscle spasm 16 62 2.31582339607426 0.0205679132574689 12.46116504854369 57.41990291262136 0.5782385518256496 0.5270109112328661 4.685854213547734 5.0957713280196595 0.8793305042203639 0.3427211662973412 8.174635286372516e-05 0.4396258949303272 0.0298058590245865 0.0007194276585776 7.936286062571851e-05 +Abnormal mitochondria in muscle tissue 6 21 2.300590315795668 0.0214147989431345 6.864077669902913 20.83252427184466 0.7962580997895766 0.3538054675594747 3.0570578650205316 2.639985737842691 1.2479322885734705 0.312408674687376 0.0004223105275086 1.0 0.004885623522166 2.006126575116942e-05 0.0002645246913318 +Hypocholesterolemia 4 7 2.292818113750179 0.0218584787242854 3.2645631067961167 8.048543689320388 1.205673434171466 0.2055905154190861 1.747510449264718 1.0646904903887575 1.232151298114248 0.2464368010987078 8.985506357909055e-05 1.0 1.0 0.0001991597833083 0.0002457979454447 +Aplasia hypoplasia of toe 7 32 2.282153244500133 0.0224802944021635 8.012135922330097 34.19660194174757 0.3898452492302285 0.5652986529849863 3.42071761916543 4.780389563155937 0.8347980433542861 0.3255608052247934 0.0991963880075411 0.0187223954820901 0.005908972667517 0.0260046292455246 0.2274554675884765 +Abnormal csf protein level 6 12 2.281312915637529 0.0225299369936755 4.434466019417476 12.20631067961165 1.1239853500963992 0.2260559983233297 2.11400242863219 2.084072511592451 1.241935948510828 0.248039542652958 0.0652708822051923 1.0 0.3143397790261298 0.2421879711614701 0.0105883475769395 +Decreased absent ankle reflexes 9 16 2.2746789395887363 0.022925196771987 4.54126213592233 13.740291262135925 0.614698131143983 0.4646843865398717 2.302541095049457 2.6371188884218366 0.9410514279256472 0.3107404522460847 0.0226697205376047 1.0 0.2372212797486779 0.0291459656321865 0.0446088038944012 +Central scotoma 3 10 2.274504557485048 0.0229356673971301 3.657766990291262 9.152912621359222 1.2790732929494344 0.2261272578521709 2.0233738200365714 2.077016218281829 1.2675536526802949 0.279373459017325 0.0200343776441642 1.0 0.0021303683071518 0.0037492480554313 0.0397044670530444 +Impaired vibratory sensation 8 29 2.2639035376924235 0.0235800483249113 7.536407766990291 29.62621359223301 0.76301203268979 0.4693506811924163 3.6948054205684504 4.667704809367026 0.9514363452495296 0.3439929646326011 0.0273120571316867 0.0484553320209439 0.0353550186833354 0.0345747530672156 0.0284374893636583 +Toe walking 9 23 2.2596679190485647 0.023841868799818 6.740291262135922 22.805825242718445 1.1386089770349623 0.3130572717722256 3.272869930973316 2.572476621751866 1.068544148592376 0.2998505070337083 0.0486707268156107 0.2143583684675494 0.3896854720293997 0.124643595331372 0.0029392451780606 +Anencephaly 2 13 2.249688725285314 0.0244687117329871 3.650485436893204 14.604368932038836 0.3352672102861634 0.6079749637780152 2.1608104280798432 2.3783571754848793 0.7012631526775229 0.2872057368613228 0.3451887448950316 1.0 0.0142561824639166 0.135543868878084 0.4787405982303483 +Gait ataxia 22 69 2.244829128747029 0.0247791040346849 14.351941747572816 68.35194174757281 0.6787136514518399 0.4783255809544575 5.256980668043156 6.678826209042067 1.046898326537344 0.3693668840587258 0.0129748884579509 0.0423539313401504 0.0212485029161671 0.0021614548794813 0.0026944138418452 +Cardiac conduction abnormality 12 32 2.242361303205464 0.0249380306598419 7.54126213592233 30.07766990291262 0.9307918135366152 0.3911403090848463 3.486554807604548 3.5456504747498965 0.9289536354013204 0.3216072900435658 0.0059393768764808 1.0 0.1967082241040804 0.0043610876134259 0.0025976903606674 +Myoclonic spasms 1 6 2.2167502740787364 0.026640161231211 1.8470873786407769 5.735436893203883 0.4111012021794172 0.4034071629491823 1.317697411431444 1.410916714116348 1.1149340295568837 0.2968871614008488 0.2275298470553583 1.0 0.0202898922491691 0.1053546389470493 0.3080842130268088 +Slowly progressive 21 58 2.216634658646776 0.0266480671788833 12.696601941747574 56.12378640776699 0.7411325364412068 0.522622208333598 5.310978564028389 4.912508033345017 0.8104226905999934 0.3549765630745758 0.0014098754635215 0.1200428680404904 0.3456909160626383 0.0339767723532767 0.0033710858273438 +Decreased activity of mitochondrial complex i 7 35 2.214998803265111 0.0267601466638125 9.281553398058252 33.63834951456311 0.9162605947168436 0.3572379048008119 4.7041965890170365 4.116953486956332 1.2998989973013628 0.34388058367185 0.0007571994119043 1.0 0.0128487417044244 2.660702259682677e-05 0.0006838111904489 +Juvenile onset 16 43 2.2092077163005213 0.0271601964305325 10.220873786407768 41.28155339805825 0.3416766536043948 0.3540580800469471 3.658644665705508 2.990007551791468 1.4952530140825149 0.3282418399186692 0.0001370059633956 0.0803264485172424 0.2497932687322087 0.0001434833065057 0.0010527524380771 +Talipes equinovarus 21 80 2.1972939604124906 0.02799945872227 17.890776699029125 76.62135922330097 0.5495068800315274 0.5880189289841166 6.331475723212702 10.674910704116524 0.8250227780407152 0.350320151193932 0.0007480569610957 0.6941672260122187 0.2156193562775763 0.2502431215746858 0.0045850074158436 +Variable expressivity 26 80 2.1923348540753764 0.0283553368189752 16.655339805825243 76.72572815533981 0.9137081973948464 0.4866305980303022 6.903822328870412 7.203694993346709 1.0588933116250316 0.3878161256963057 0.0005938837614896 0.6325910777230552 0.1434578911288594 0.0309868570698005 0.0066024268890501 +Proximal tubulopathy 6 23 2.192318023854725 0.0283565512032257 7.269417475728155 23.25 0.6812729764745832 0.3939568357360496 3.269858916003623 2.8782959157530654 1.2124757185225692 0.3205652179980567 0.0012872527094995 1.0 0.0080456420559546 6.706147432458563e-05 0.0009402069411773 +Lower limb spasticity 18 78 2.1901549683040544 0.0285129998476438 17.24271844660194 80.34466019417475 0.5234592060757025 0.5553383930423336 6.384471482056576 8.884788223572686 0.9712236167697867 0.3629508150226985 0.0009010365265974 0.2145941351879337 0.0320350988090082 0.0049863628675692 0.0015154633182365 +Abnormality of fontanelles 15 43 2.187298604557165 0.0287207325442637 12.533980582524272 46.23543689320388 0.679338498231045 0.5021510160434427 4.713779704909753 4.753170281164529 0.9735403185104452 0.3677424081230729 0.0078761484810802 1.0 0.1106597635259331 0.0724012208448934 0.0143684953141881 +Abnormal biliary tract morphology 6 24 2.184852125565246 0.0288996906912173 7.427184466019417 23.174757281553397 1.329418499193971 0.249884151345828 2.8924137189053876 2.044064029481889 1.3393824039546371 0.2984385007787948 0.0044019654707163 0.2217755071466549 0.0919415891551245 0.0016490180911792 0.00375910232126 +Cardiorespiratory arrest 2 5 2.17314948346933 0.0297690684161886 0.8398058252427184 3.186893203883495 1.1916183564957985 0.2780332750830487 0.8638185495623535 1.3077524847654174 1.1514955264290567 0.2658790073928831 0.0028961418368086 1.0 1.0 0.1775366954381628 0.0053031795330487 +Aplasia hypoplasia involving the vertebral column 9 16 2.168873203319524 0.0300923116665479 4.679611650485437 14.847087378640778 0.8883735186508074 0.3527358077962234 2.3127489306396716 2.051146083169333 0.9597872998017484 0.2871451112966173 0.0062571979838837 1.0 0.3404254693467198 0.0195417527514502 0.0042906431799932 +Sensory neuropathy 10 36 2.1678737693226657 0.0301682921209989 9.17233009708738 33.75485436893204 0.684837850359792 0.4572087500958895 3.983815730493952 4.346698415431409 1.0448123352909229 0.3439679266340525 0.0025519536882883 1.0 0.162236447621752 0.1071524979756758 0.0101126006284967 +Nephrotic syndrome 6 31 2.166620993189042 0.0302637653189108 6.691747572815534 26.449029126213592 0.5692557086068671 0.4287880468715059 3.1782986616871702 3.4415823902191023 1.075640445131052 0.3251004953320756 0.0899647705670742 0.3716550187930373 0.0681614338573012 0.0094008643755842 0.1980954333562903 +Biliary tract abnormality 7 28 2.162507330127477 0.0305790927009883 8.184466019417476 26.4004854368932 1.3038634098573934 0.2674323053300255 3.1080777089644696 2.335313487465734 1.3483489456318312 0.3101233364725878 0.0033803650417231 0.2613604367755145 0.1258733376055511 0.0043231258251732 0.0035432778392652 +Abnormality of glycolipid metabolism 5 6 2.1609468904543685 0.0306994421844919 3.83495145631068 7.228155339805825 0.3163887308740252 0.1681411938672545 1.311614193945771 0.5964160722258837 1.870431483654663 0.2292796295173983 0.0004059252135544 1.0 0.0921025797166938 0.0014684283121974 5.436360967141595e-05 +Splenomegaly 22 83 2.1594508743983183 0.030815204637733 20.660194174757283 86.74029126213593 0.5649049994066069 0.3835571498509289 6.419862077062851 7.868335701486235 1.546158503499524 0.3590721878602594 0.0002908000814951 0.2967968168404439 0.0715157250646603 0.0014170428158922 0.0008395188894158 +Delayed cranial suture closure 11 30 2.1554455300355224 0.0311269867409369 7.716019417475728 29.325242718446603 0.7058204487281402 0.4787858893421486 2.9402522313721624 1.8749870392614547 0.9549766649562498 0.3518038054905379 0.0003887342701285 1.0 0.107004894081217 0.0509365284789281 0.0004229506315236 +Chronic pulmonary obstruction 2 5 2.145333325265673 0.0319262058280396 1.7912621359223302 6.975728155339806 0.7151400882135658 0.3422892186915894 1.3201652438579738 1.3051032038511063 1.0511250125541778 0.2765518721331778 0.0416226685335461 1.0 0.1758008751515455 0.0116756742779249 0.0701952648708137 +Osteoarthritis 5 10 2.1384538423353425 0.0324799265416884 3.783980582524272 10.466019417475728 1.011181157871384 0.2141266987491498 1.7388858389175554 1.4384831140913243 1.3548711699904423 0.2434324139099127 0.0226697205376047 0.1239247827595126 0.0293903981750984 0.1457934990596532 0.010278445998416 +Progressive gait ataxia 5 12 2.131015629702705 0.0330878545771822 3.3810679611650487 11.0873786407767 0.9190295749650902 0.2658532875386696 1.7592835107251577 1.880439920211323 1.2434873962438642 0.2734996669217905 0.0114287110152524 0.1029565435856987 0.0202898922491691 0.0172025832638257 0.0006318501388434 +Diffuse white matter abnormalities 6 10 2.1293630548663995 0.0332242346430884 2.9514563106796117 8.87135922330097 0.5952845668725205 0.3852144131329246 1.9847899342355348 1.8774220853320651 1.0510828155917642 0.2960660984241839 0.0800372925933584 1.0 1.0 0.1292409073430241 0.0351238878380088 +Left ventricular hypertrophy 9 25 2.129156512436166 0.0332413134939286 7.567961165048544 23.54126213592233 0.6997255266541987 0.4097452846499351 3.537969183053948 3.034709621147107 1.2051726960058406 0.3398649994618895 0.0144258879578787 1.0 0.4724360815693985 0.2130027955338551 0.0401410360295106 +Abnormal brainstem mri signal intensity 6 20 2.125355315917284 0.0335569758273168 6.252427184466019 20.32281553398058 0.9466857218441096 0.334812084954676 2.9078682900486936 2.582646312540884 1.1241621585657078 0.2967087697298931 0.0005035364296941 1.0 0.048990890514732 0.0002303056568621 0.0003233683313873 +Abnormal sella turcica morphology 3 7 2.1242795911592567 0.0336467712604742 2.1310679611650487 7.259708737864078 0.3527899633564624 0.3302362894597835 1.2627239108344035 1.5017879029535528 1.2692310088213898 0.2695913026312082 0.0046090980714051 1.0 1.0 0.0688460117016781 0.0097510399506001 +Impaired social interactions 13 47 2.123095484927156 0.033745851300369 12.00242718446602 47.49029126213592 0.5604537103987376 0.5219910099489533 4.425488172516818 5.269200019661922 1.0091183008466462 0.3500212759055819 0.0006824435676773 0.3864505475849718 0.0766374872717975 0.0001835775213899 0.0004329548950732 +Hypersplenism 3 6 2.1114370719367925 0.0347347614401767 2.7184466019417477 7.970873786407767 0.2142260937784027 0.1548364087136437 1.1589036979530396 1.1444786041391362 1.8316571038254568 0.2005205006822401 0.002916997936102 0.0727733471903131 0.1432798584585485 0.0061570039439817 0.0062633876942655 +Abnormal circulating copper concentration 3 6 2.110973381263219 0.0347745998931929 1.8422330097087376 5.575242718446602 0.7192357902216235 0.3771156375814327 1.260629702441343 1.0104640332277932 0.9717173289058264 0.2836036003591781 0.0001440761934787 1.0 1.0 0.0007102815399137 0.0003286021100258 +Mania 3 13 2.10994119362818 0.0348634214667571 4.29126213592233 13.815533980582524 0.5633198814967983 0.4160552944360035 2.179476502394243 2.2801276272213657 1.0919629859527038 0.3085705503430486 0.0317940073744775 1.0 0.0354914601129098 0.0379489226270714 0.0612536211646263 +Microcytic anemia 3 9 2.108907264234281 0.0349525870636842 2.441747572815534 8.526699029126213 0.6645628317552182 0.3838242289014166 1.6704179043327654 1.438636684975842 1.0496853438983738 0.3012783873714112 0.0114287110152524 1.0 0.0202898922491691 0.0172025832638257 0.0233101974365333 +Macroglossia 14 36 2.106688475005773 0.0351445918609547 8.597087378640778 33.800970873786405 0.2378332400826553 0.526108686434358 3.4819634097071916 3.0993577519995683 1.045257905641647 0.335668429128709 0.0468025470215324 0.3835189953423699 0.2569300433589926 0.0366846925917218 0.0260247872725496 +Loss of speech 6 19 2.105853236873168 0.0352171027802068 5.453883495145631 19.1626213592233 0.4726173662677797 0.3013153148889984 2.223071754411353 1.8941045281154043 1.521023928928509 0.3006842241053739 0.0233905612806522 0.1801156574188796 0.0614247268920475 0.0180565405233996 0.0037452233271246 +Abnormal ldl cholesterol concentration 6 11 2.099400954136971 0.0357815706647357 3.3907766990291264 12.616504854368932 0.1598459071865069 0.3035988995241804 1.922077248743316 1.8231306205769169 1.371220486686296 0.2515253044142337 0.0030137793172406 1.0 1.0 0.0032545859437725 0.0012730265791845 +Impaired vibration sensation in the lower limbs 4 12 2.093183138586748 0.0363328093328849 3.5436893203883497 13.5752427184466 0.6952737045250533 0.4242336391370475 2.2993316843683766 2.2069327415111175 1.0005780794846004 0.3215228956981494 0.017409601938399 0.1683799151698467 0.0538434207197609 0.0671599559498881 0.0390278099301106 +Mitochondrial inheritance 2 5 2.0909374470609725 0.0365336717144115 1.577669902912621 4.247572815533981 0.9928856357718184 0.2727497270810077 1.119676794457053 1.2095369137272214 1.2442723588935711 0.2811589341958167 0.0191851660395208 1.0 0.0088504827764808 0.0050923434600555 0.0334620993119388 +Mixed demyelinating and axonal polyneuropathy 2 5 2.0898085939896425 0.0366349970575419 1.4757281553398058 3.861650485436894 1.0618051586825854 0.3019785112671438 0.9638581472614256 1.1670164407518866 1.082154445030509 0.304718894009896 0.0058525380795408 1.0 0.0921025797166938 0.0229613270793894 0.0105668672564949 +Arrhinencephaly 1 9 2.089789616951144 0.0366367024721363 2.820388349514563 10.618932038834952 0.1582883952723028 0.6479762207194159 2.121725768692591 1.742649145388988 0.6577512081319555 0.2676349927984151 0.3011249286568631 1.0 0.0293903981750984 0.1457934990596532 0.3973105708638685 +Increased serum pyruvate 12 33 2.078076873769358 0.0377022793047816 9.303398058252426 32.64563106796116 0.7845790996019184 0.387018609503293 3.945341127018032 3.24570744750092 1.0586848930233297 0.3138975633269482 1.793043200757267e-08 1.0 0.0748026769138462 1.0436029754002213e-08 2.6206893509696613e-08 +Flat face 8 23 2.078023789748805 0.0377071680614389 6.66747572815534 24.08495145631068 0.4902055675682596 0.5473999825637093 3.284800305273881 3.633055728953568 0.8018127166907104 0.315636792407103 0.0329398811979505 1.0 0.5305553861952955 0.2908433959862969 0.0129291666059707 +Progressive psychomotor deterioration 5 7 2.073708997360514 0.0381063451146557 3.349514563106796 8.320388349514563 0.5379615244672443 0.2176134167318772 1.5053866894387542 0.6226094824456632 1.5848775742530583 0.2457660654605461 0.000898746356534 1.0 0.1094892401774078 0.0001405335592956 0.0001575214550341 +Elevated pulmonary artery pressure 6 23 2.0736204524138246 0.0381145742113262 7.422330097087379 24.033980582524272 0.8771466934674594 0.3206437689207037 3.083196929894625 3.78086786662344 1.283632173810104 0.3146045769490745 0.0599702405308579 0.344137720202208 0.0105112684317993 0.0637395822669413 0.1407079899645458 +Cutis laxa 11 34 2.073479664611144 0.0381276617108365 7.786407766990291 30.567961165048544 0.1942452097651432 0.5993697737339392 3.4525929061320935 3.496564571735676 0.8896354286885394 0.3267193204344998 0.0092129387021807 1.0 0.5863803216648996 0.1770898669719441 0.004440620169591 +Abnormality of visual evoked potentials 7 21 2.0714425219971413 0.0383174606223137 5.912621359223301 21.344660194174757 0.5310511795384435 0.4083718861321034 3.290488782756552 2.4160960308239137 1.1796429833196167 0.3304773196682204 0.0256449511882959 1.0 0.3404254693467198 0.0846608217542885 0.0168189007239576 +Capillary hemangioma 2 7 2.070462672585539 0.0384090380983861 2.533980582524272 7.133495145631068 1.1471796350867234 0.2683759543048971 1.4112277515033682 1.3471092449900268 0.9767941621718578 0.2786452679412407 0.1380592378571038 0.1444128696349771 0.2732850813359189 0.1887844423268079 0.2143350029099695 +Psychomotor deterioration 3 7 2.0679551242703336 0.0386442431191011 3.2645631067961167 8.910194174757281 0.9753014938956188 0.1960965459818884 1.3866235282600423 0.7031088807706056 1.4929387846379636 0.2609606457365817 0.0012582535978488 0.0595353304203936 0.1180585699575878 0.0033170374819039 0.0027630263410089 +Abnormal tongue morphology 25 71 2.0669565681150126 0.0387382466492529 16.939320388349515 69.1116504854369 0.4277424777250148 0.5766387697572775 5.679438944349523 6.766002978496539 0.9505300446189564 0.3567930620053219 0.0806224348881078 0.6413385078849175 0.1523375754543642 0.0763506782412786 0.0588487404011599 +Abnormality of extrapyramidal motor function 26 77 2.0599941367512544 0.0393991013437338 17.723300970873787 74.23058252427184 0.6611914449106878 0.5008095396366101 5.517064505158221 6.985611887807198 1.1554912414277594 0.3847143245763222 0.1084401838739974 0.2512059527024609 0.1347944849764237 0.3743026550183664 0.0738177159624069 +Abnormality of the mitochondrion 31 98 2.055210061871864 0.0398587196973971 24.216019417475728 91.8883495145631 0.797381253925538 0.4153343301115782 10.704523845407817 8.200885590005743 1.4941762160347407 0.3812617801525748 1.3452466683320066e-06 0.1769465030312334 0.000159979885933 3.480511037132019e-07 2.466049003727128e-07 +Fasciculations 16 40 2.0452464387113234 0.0408305682812366 9.201456310679612 36.5 0.4731561459207285 0.4826265043963199 3.4648999783170837 3.557775567723639 1.0532476984865673 0.3454376907067654 0.0015692063317428 0.2821140734917597 0.4925597827158772 0.0266777247012389 0.0005068238920592 +Abnormal left ventricle morphology 11 30 2.045036976342436 0.0408512128124287 8.155339805825243 27.79368932038835 0.5948246759118737 0.4756129570470222 3.598158324912058 3.3281177777105677 1.054918773522773 0.3428402347836221 0.0148231317508413 1.0 0.5484830827387088 0.3173461003371735 0.0175418047376826 +Retinopathy 10 26 2.0417698704292166 0.0411743642675035 7.716019417475728 27.516990291262136 0.7648928031827923 0.4912060355555205 3.3040774573673595 3.4588008851352714 0.8590527654816497 0.3424638793573584 0.0138339601940861 0.3186897272236745 0.1827953867238 0.0457838139336303 0.042276670816049 +Dysdiadochokinesis 7 16 2.0411383928485343 0.0412370731844551 4.157766990291262 15.45388349514563 0.6684839389883598 0.4186205101687726 2.0089273726107977 1.5439545323865935 0.9784437725207784 0.3063164957116248 0.1290458946587116 1.0 0.266209970857853 0.1800390494619342 0.0674365169251515 +Ascites 8 27 2.0397900606312427 0.0413712402082204 6.538834951456311 25.800970873786408 0.2860997134153194 0.2561597752608451 2.6559964399945706 3.331112387328855 1.6846905274497244 0.2824645045304154 0.0208789741874162 0.0439058261029628 0.1487873266068847 0.092069152986564 0.0211829876625836 +Abnormality of epiphysis morphology 16 57 2.0373094719062306 0.0416190392449167 14.885922330097088 57.24757281553398 0.6699051414631522 0.4959188251133739 5.664066249559964 8.729587504130462 1.029966158611096 0.3689041276003297 0.0081739969843115 0.597404740435969 0.8446675734226833 0.8441742661356123 0.0115215184593279 +Scotoma 3 13 2.034521689142343 0.0418990240658738 4.189320388349515 12.196601941747574 1.1271039056750725 0.2779036999445621 2.1128553643245884 2.0698220238662226 1.1901076059375446 0.2884356618441315 0.0703814677508988 1.0 0.0065760397653667 0.0153023562212604 0.1274755097437061 +Dysmetria 15 57 2.0318336895853903 0.0421704953508343 14.618932038834952 55.148058252427184 0.6447099310037795 0.5301040823699991 5.464619727151339 6.3203263646610806 0.9326090127326924 0.3593910006397782 0.0038771844785421 0.4502315225881613 0.1209939299005533 0.0327491618218664 0.0031346425103821 +Abnormality of skull ossification 7 13 2.0299294310065688 0.0423637129823017 4.366504854368932 12.970873786407768 1.1881205011944458 0.2637442069575459 1.99249670608582 1.4511884027191762 0.8848235988748787 0.2626440236811827 0.0018564811497816 1.0 0.2802926639431586 0.0479498850625808 0.0053527619374205 +Atlantoaxial abnormality 3 5 2.0234884176802925 0.0430228165246668 1.4660194174757282 3.849514563106796 1.0726212659562588 0.2746386395490074 0.9171032274068438 1.0957440869823794 1.0965015067037602 0.2693675199183011 0.0004059252135544 1.0 0.0921025797166938 0.0229613270793894 0.0009118158302113 +Retinal dysplasia 5 10 2.023461430850197 0.0430255961947225 2.6990291262135924 7.878640776699029 0.934970332417222 0.3353928049199215 1.4834684590696818 1.182325377441881 0.8740525348763903 0.2730031671079428 0.0016982309129601 1.0 0.0013262573806951 0.0020400745925255 0.0006318501388434 +3 methylglutaconic aciduria 5 12 2.0199052915621567 0.0433932123117002 4.072815533980583 10.594660194174756 0.3579974396117663 0.4371570089867337 2.2174372584356252 1.5620718849823747 1.1566220028171512 0.333066618505644 0.0046090980714051 1.0 0.1596960736798767 0.0007750266814789 0.0001429815632908 +Urinary glycosaminoglycan excretion 4 7 2.019597983426216 0.0434251045053044 2.9490291262135924 6.563106796116505 0.4749855796693131 0.2196485727407601 1.2846457065606351 0.9261036754709504 1.6390629541794843 0.2603486997442626 0.0001964363060589 1.0 1.0 0.0050923434600555 0.0005289198821125 +Focal t2 hyperintense brainstem lesion 5 17 2.01419812854648 0.0439887361064197 5.745145631067961 17.558252427184467 0.7787968952644161 0.3563659539921697 2.720936576360794 2.4403574571781053 1.1656572167307155 0.3009968442621839 0.0011224085103745 1.0 0.0354914601129098 8.233120100309505e-05 0.0005790030159305 +Abnormal cardiac ventricular function 8 18 2.01320687602797 0.0440928701762866 5.262135922330097 18.648058252427184 0.6561483334031016 0.4063512942618581 2.801563935800768 3.037775296806565 1.0608023601658336 0.302693194134391 0.1775224527264409 1.0 0.1656331484196294 0.2776494479137136 0.3089718606678731 +Arthritis 10 39 2.011020600670185 0.04432328079859 10.45631067961165 41.12864077669903 0.9299077951686036 0.3844403642845474 3.7326340917241647 4.351147052994631 1.200139433310656 0.3557501916131977 0.0097577055704047 0.0916019579859948 0.0201115001422002 0.1198850598560501 0.0155366639957927 +Dyschromatopsia 2 8 2.009817102805463 0.0444505499739098 1.9563106796116505 6.881067961165049 0.8116181676256156 0.3616454151850379 1.3027357251175682 1.008666728011197 0.9552278076961072 0.2951208666933738 0.0078154121226846 1.0 0.0047533286028597 0.001983278822638 0.0140126286640228 +Ovoid vertebral bodies 3 8 2.0082333557438057 0.0446185000308458 2.6237864077669903 7.359223300970874 0.2693483252678329 0.2925663833748981 1.3659227234427256 1.183251804829311 1.455225024558189 0.2873440473038876 0.00821576936754 1.0 1.0 0.0901924811619011 0.017002584405276 +Abnormality of pulmonary circulation 7 27 2.000684102023383 0.0454264437552698 8.439320388349515 28.538834951456312 0.8940347945025898 0.342085103264471 3.349932259027002 4.295622811850572 1.233599840087162 0.3264185554851845 0.0589652108234748 0.3980408639782044 0.0195066935662917 0.1164819330840205 0.1482732403897816 +Episodic vomiting 2 10 1.995413658558436 0.0459977824722748 4.179611650485437 11.12378640776699 1.060494846441687 0.2663322982599159 1.9809215871966128 1.7630834730718608 1.1982900451883365 0.2840581402107739 0.1202524172357033 1.0 0.0354914601129098 0.0379489226270714 0.1889957663081205 +Amyotrophic lateral sclerosis 6 18 1.9931777611565624 0.0462419853941964 4.453883495145631 16.203883495145632 1.0855969203541704 0.3037117925086244 2.3812188822255287 1.5445439412417563 1.0118111691913367 0.2917679915833991 0.0756909974604541 0.1762218760282218 0.0588586045542952 0.260178364686727 0.0134528362725409 +Abnormal saccadic eye movements 6 28 1.9917311357937064 0.0464005655735264 6.293689320388349 24.570388349514563 0.6352395547829492 0.4765898942028741 2.9458970942458165 3.3125821982342476 0.9514629694011908 0.3397171221111555 0.0168066225602795 0.2752604452820565 0.1388614812827933 0.0814773755217055 0.0460574281433519 +Global brain atrophy 9 21 1.9891843810988012 0.0466808552319131 4.944174757281553 20.466019417475728 0.5470181350831151 0.5081828354508747 2.583421763532785 2.0184370286085005 0.920761985531802 0.3339660659374047 0.0305594127171181 1.0 1.0 0.0940672040532474 0.020723717832043 +Abnormal visual electrophysiology 15 52 1.9826968904798852 0.0474012971414743 11.310679611650484 49.08009708737864 0.5738496712827478 0.4298926605512212 5.601714588788375 4.822166856762376 1.2686017151039417 0.3684491475281102 0.0567751963487199 0.1470901062438777 0.0124644356717177 0.0232625208838642 0.0910704942535952 +Coarse hair 7 20 1.981678411554616 0.0475152449331288 4.686893203883495 18.616504854368937 0.2343700701412837 0.5417146669091575 2.329949176130645 1.927954652781107 0.8671729178541636 0.2932988727143946 0.000160043124944 1.0 1.0 0.0166437437365411 0.0006746347610051 +Central apnea 2 8 1.9745526612675357 0.0483189356989171 2.6140776699029127 7.645631067961165 0.7865100475706397 0.3005269589284746 1.5309416715650457 0.8593604190958345 1.1613991531101726 0.2793709321885783 0.0659351237154193 1.0 0.2070995190727305 0.0193169154759243 0.1083207684216986 +Airway obstruction 6 13 1.9724699189615489 0.0485559869779932 4.116504854368932 15.12378640776699 0.9459797966632624 0.3434111484412289 1.9597947726604712 2.1010208413382245 1.0021021721123982 0.3085532788047633 0.0763520743504577 1.0 0.107004894081217 0.0509365284789281 0.0611543838186325 +Ventricular arrhythmia 13 41 1.9687658815328464 0.0489799819267773 10.0 36.96601941747573 1.0415384316890377 0.3677574027458479 3.8522468541414527 4.8022861343455805 1.0152201826292362 0.3231502492090489 0.0174755029317534 1.0 0.0731929968318565 0.0110026098329487 0.009676698656285 +Abnormal larynx physiology 5 17 1.9676616264831548 0.0491069838622217 3.7694174757281553 14.78640776699029 0.7777362681295714 0.3936810823701626 2.010346212391085 1.51625807571557 0.9784109402665334 0.3028779878197117 0.0511587047594285 0.1564797373419447 0.0466281418945222 0.2153304097941032 0.0071436537580251 +Abnormal renal tubule morphology 5 27 1.966973159501216 0.0491863052026229 5.12378640776699 23.57281553398058 0.5344796879802587 0.5091115156098857 3.0444469953961124 3.073064760825049 0.9046179239778558 0.3270470399524735 0.0561146044717888 1.0 0.4925597827158772 0.0266777247012389 0.052504971472103 +Abnormality of lipoprotein cholesterol concentration 6 12 1.9665124262922449 0.0492394483527891 3.594660194174758 13.79126213592233 0.146670453757452 0.3159030988618912 2.0804850608489107 1.8940687593815968 1.3545369944331518 0.2589389983473483 0.0057417875723139 1.0 1.0 0.0055331858379351 0.0027845492980534 +Positive romberg sign 4 10 1.966088261300927 0.0492884161390096 2.466019417475728 8.308252427184467 1.0733671875840938 0.3096488241780741 1.4485716699970723 1.6764009803624336 0.8283755892460324 0.2651507773538893 0.0191851660395208 1.0 0.1349531130589082 0.0050923434600555 0.0334620993119388 +Generalized hyperkeratosis 3 5 1.9649303250751888 0.0494223023142359 1.730582524271845 4.912621359223301 1.0808782092062823 0.2557560852549371 1.1711485734328595 0.780301113356215 1.0121219678622022 0.243080004206366 0.0058525380795408 1.0 0.0921025797166938 0.0014684283121974 0.0105668672564949 +Eeg with focal spikes 1 6 1.9642047419462465 0.0495063531295849 1.199029126213592 4.611650485436893 0.2009379318587673 0.3945439266933198 1.2224434504069814 1.009498671202671 1.1758184518685515 0.2899583413391119 0.0560883044213639 1.0 0.0921025797166938 0.0229613270793894 0.0817606313480972 +Premature rupture of membranes 3 6 1.9628909899806224 0.0496588419310182 1.5631067961165048 5.800970873786408 0.9509293139272904 0.2937126614282376 1.1899245542912666 0.3992700002908385 1.068670600999266 0.275907562675117 0.0460411511547768 1.0 0.0832836732680532 0.0186627473263165 0.0076703518288617 +Abnormal blood transition element cation concentration 4 12 1.9624746129335493 0.0497072534601863 3.344660194174758 11.774271844660197 0.3680784158905049 0.5579647201552179 2.097767104871171 1.222768704514986 0.7746102475847948 0.2991566296631489 0.000862192784611 1.0 1.0 0.0011814468070448 0.00223229240551 diff --git a/msigdb_hp/metrics.json b/msigdb_hp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..96fdd6386e9be170400ff5f5e3267010e44f3999 --- /dev/null +++ b/msigdb_hp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3120, + "annotations_size": 4591, + "title": "Average number of proteins per term", + "value": 23.660204748420824 +} \ No newline at end of file diff --git a/msigdb_hp/paths.json b/msigdb_hp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..cf751042120a7dff4429d31c1176ba0fbc5d998a --- /dev/null +++ b/msigdb_hp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_hp/fragment/C390/C390_val_log2fc"} \ No newline at end of file diff --git a/msigdb_hp/result.tsv b/msigdb_hp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..ce896f0109650099541936bf287ca6ed4f13d551 --- /dev/null +++ b/msigdb_hp/result.tsv @@ -0,0 +1,1711 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Muscle abnormality related to mitochondrial dysfunction 0.619824812627663 3.244218135733779 0.0011777351511532 0.9955291135431308 0.5539034810165695 37 Q86Y39,Q53H12,O60313,Q96CU9,Q9Y6M9,Q9UBX3,O96000,Q9Y2R0,P00846,P00403,Q8IUX1 11 +Dementia 0.5284820293640826 3.2006289038212987 0.0013712801671001 0.9981634522212228 0.5539034810165695 61 Q9Y487,O15118,P04062,P35637,Q14108,Q9UHD9,Q13510,P02792,P21912,P00846,Q9UQN3,P17900,O60313,P35670,Q9NZJ7,P00403,P20700,O43681,Q9NQZ5,P22626,O76024,O96008,P06865 23 +Horizontal nystagmus 0.683422573201737 3.0793461239449806 0.0020745550683396 0.9999276630379376 0.5539034810165695 22 O14773,Q9H061,Q9NW15,O95831,O60313,P04062,Q9NZJ7,P00846 8 +Abnormal activity of mitochondrial respiratory chain 0.5420861661604583 3.0445191994682888 0.0023305255441317 0.9999777224216436 0.5539034810165695 54 P13073,P20674,Q70HW3,Q86Y39,Q9P0J0,Q96CU9,Q9Y6M9,P21912,Q9UBX3,O96000,Q9Y2R0,Q7KZN9,Q8IUX1 13 +Hepatic failure 0.5632907934658411 3.0418404510979644 0.0023513649213229 0.9999797595587524 0.5539034810165695 48 P09622,O43772,P22830,O75381,Q13510,O75845,P38571,O15118,P04062,Q10713,P35670,P23786,P00846,P50416 14 +Corneal opacity 0.5372077239644082 3.0351178426295182 0.0024044172048787 0.9999841441413292 0.5539034810165695 55 Q6NUK1,O75381,Q16625,Q06136,P04062,O95202,P06280,Q13510,P51648,P40855,Q15645,P35670,Q9NX14,O75844,P10619,O75845,O43505,P08236,Q9NVI7,Q5H8A4,P04066,Q14118,P16278 23 +Abnormality of hepatobiliary system physiology 0.515318702194818 3.029694120973271 0.0024480152880104 0.999987026699278 0.5539034810165695 79 Q5XKP0,Q9BT22,Q16625,O15118,P04062,P23786,P50416,O43772,O95169,Q13510,Q10713,P00846,P22830,P22695,P35670,O43819,O75845,P09622,P38571,Q9Y276,Q96A33 21 +Mitochondrial myopathy 0.6156478540712126 2.9996140008599195 0.0027032194242662 0.999995992266921 0.5539034810165695 30 Q86Y39,Q53H12,O60313,Q96CU9,Q9Y6M9,O96000,P00846,P00403,Q8IUX1 9 +Abnormal circulating lipid concentration 0.5052350493471707 2.9835715508225653 0.0028490541315269 0.9999979520593056 0.5539034810165695 74 O75381,Q15738,Q03252,Q15392,O75880,P23786,P50402,P31751,P50416,P06280,Q96MF7,O43772,P40855,P02545,Q9UJS0,P49257,Q15904,Q10471,P22830,Q9NZJ7,Q9BV10,Q9BTV4,P37268,O75844,O75845,Q9Y4P3,P09622,Q9NVI7,P38571,O75431,O95470,Q16836,Q15800,O75648 34 +Abnormal retinal artery morphology 0.6762969029376855 2.9563307422136225 0.0031132305076591 0.9999993932421168 0.5539034810165695 20 P17900,Q13510,P16278,Q9NZJ7,P21964,P10619,P00846 7 +Impaired proprioception 0.574945869784687 2.9019697128187705 0.0037082439036035 0.9999999608627682 0.5539034810165695 38 O14773,Q13217,Q9NR77,P20700,Q8IV08,O94905,O75298,O95140,P54802,Q9H6K4,O43819,P07196,P00846 13 +Optic disc pallor 0.5455492134255143 2.8831861349298795 0.0039367474367724 0.9999999863465928 0.5539034810165695 48 Q9UG56,Q96L58,Q8WWY3,Q86Y39,Q96CU9,O96000,Q10713,Q9H6K4,P00846,Q9H061,O75306,Q9GZY8,O95831,O60313,Q9Y6M9,Q6P4Q7,Q9NX14,Q8IUX1,O95140,Q9NPL8 20 +Mental deterioration 0.5254001087807952 2.872515548583874 0.0040721803965815 0.99999999268654 0.5539034810165695 102 Q9Y487,Q5XKP0,O15118,P04062,P35637,Q14108,O95169,Q13510,Q9UHD9,P50897,P21912,Q10713,P00846,Q9UQN3,O75503,P17900,O60313,P35670,Q9NZJ7,O43819,P21964,P00403,P20700,O43681,O95470,Q9NQZ5,P22626,O95140,O76024,P16278,Q9NPL8,P54802,P06865 33 +Disproportionate short stature 0.6356943223381081 2.841229850690453 0.0044939909202601 0.9999999989541244 0.5539034810165695 24 Q7LGA3,Q7RTS9,Q32P28,Q9H6U8,Q9UHX1,Q15392,P16278,O00116,Q9BV10,Q96MF7 10 +Abnormality of head blood vessel 0.629050328314789 2.7538761976137582 0.0058894041555384 0.99999999999833 0.5539034810165695 23 P17900,Q13510,P16278,Q9NZJ7,P21964,P10619,P00846 7 +Poor eye contact 0.557598862076549 2.7400787452104773 0.0061424465900814 0.9999999999994812 0.5539034810165695 37 Q5XKP0,Q86Y39,Q9UHX1,Q9P0J0,Q96CU9,Q9Y6M9,O96000,Q15907,Q8IUX1 9 +Hyperlipidemia 0.5791028735896024 2.7203683236697405 0.0065209237140211 0.9999999999999096 0.5539034810165695 30 P06280,P50416,P22830,P38571,O95470,O75844,Q9UJS0,P23786,P50402,Q96MF7 10 +Abnormal circulating cholesterol concentration 0.5778829171780958 2.710887732659044 0.0067103342226679 0.9999999999999624 0.5539034810165695 30 Q10471,Q9NVI7,O75845,P38571,O75431,Q15738,Q15800,Q15392,Q9UJS0,P02545,Q9NZJ7,Q9BTV4,Q9BV10,P37268,P50402,Q15904 16 +Poor head control 0.4746590426835099 2.7043964226334336 0.0068428599235115 0.9999999999999796 0.5539034810165695 70 P13073,Q5XKP0,P17900,Q86Y39,Q9P0J0,Q96CU9,O95721,P21912,Q9Y6M9,O96000,Q14118,Q10713,P00374,Q9NPL8,Q9NZJ7,P06865,Q8IUX1 17 +Bulbar signs 0.7639664369798609 2.692341925612892 0.0070952161390536 0.9999999999999936 0.5539034810165695 12 Q99720,Q15043,P04062,Q9NZJ7,P35637,P00846 6 +Limb ataxia 0.595239249202416 2.687220558292883 0.007204936025756 0.9999999999999962 0.5539034810165695 27 O14773,Q9NW15,Q14108,Q8IV08,P04062,Q10713,P07196,O75298 8 +Proximal muscle weakness 0.4686078897600314 2.668216549950682 0.0076255091516153 0.9999999999999994 0.5539034810165695 63 Q99720,Q8TB36,Q9H9S5,P35637,P50402,Q8NI60,Q13510,Q9BQT8,Q13501,Q86U42,P21912,P02545,P07196,P00846,P12235,O60313,P35670,Q9BTV4,Q9BPX6,P13473,P10253,P22626,O95140,Q8TD16,Q14118 25 +Postural tremor 0.6463425369106894 2.657805236280305 0.0078651331444046 0.9999999999999998 0.5539034810165695 19 O14773,Q9NR77,O75569,Q14108,O75306,P35637,P20700,O95140,Q9H6K4,P04350,P00846 11 +Abnormality of corneal stroma 0.7392689427359053 2.653972679613862 0.0079550267373535 1.0 0.5539034810165695 13 O43505,Q13510,Q16625,P04062,P16278,P10619 6 +Cherry red spot of the macula 0.8445083141755624 2.6504071955614426 0.0080394810925967 1.0 0.5539034810165695 8 P17900,Q13510,P16278,Q9NZJ7,P10619 5 +Areflexia of lower limbs 0.6077879200857919 2.6451968126538232 0.0081643414968088 1.0 0.5539034810165695 24 Q13217,Q9NR77,P12235,O75477,Q13501,O60313,O95140,O75787,Q15120,Q15041,Q9H6K4,P07196,Q16637,Q15067,Q96RL7 15 +Abnormal muscle fiber morphology 0.4698001591645817 2.6385728538743143 0.0083255809127853 1.0 0.5539034810165695 71 Q99720,Q9H9S5,Q9H2D1,P35637,P23786,P50402,Q8NI60,Q70HW3,P61978,Q13501,Q86U42,O14979,P02545,P07196,P00846,P12235,Q9Y4W6,Q5JTV8,O95831,O60313,Q9BTV4,P00403,Q9BPX6,Q9Y276,P22626,O75648,Q14118,O96008 28 +Optic neuropathy 0.6156297362188752 2.622901820938025 0.0087184392227985 1.0 0.5539034810165695 22 Q86Y39,Q9P0J0,Q96CU9,Q9Y6M9,O96000,P00846,Q8IUX1 7 +Clumsiness 0.61524871702706 2.620264722404618 0.0087861533935762 1.0 0.5539034810165695 22 O14773,Q9NR77,O75503,Q05086,Q13510,P35670,Q9NZJ7,O43819,Q15067 9 +Action tremor 0.490333716167195 2.577546316949997 0.0099504545232438 1.0 0.5539034810165695 55 O14773,Q99720,P41440,Q9NW15,O75027,P35637,Q14108,Q9H6K4,Q8NC56,P04350,P00846,Q9NR77,O75306,Q9NZJ7,P20700,O43681,Q9BUB7,O95140,O75787,Q5JRX3 20 +Hyperintensity of cerebral white matter on mri 0.6612805502823169 2.568497242448847 0.0102140524798193 1.0 0.5539034810165695 17 O75503,P20700,P17900,Q15043,P10253,P21912,Q9NZJ7,Q8NC56 8 +Sensorimotor neuropathy 0.5594706542973198 2.566517984787012 0.0102725298018959 1.0 0.5539034810165695 30 Q13217,Q9NR77,P41440,P05023,O95831,O60313,Q9Y2R0,Q9NZJ7,P07196,P00846,P00403 11 +Ragged red muscle fibers 0.6303911647028623 2.5534500435472975 0.0106661578260949 1.0 0.5539034810165695 19 P12235,Q70HW3,Q9H2D1,Q86U42,O95831,Q9Y276,O75648,P00846,P00403 9 +Ectopic calcification 0.4793565284705986 2.5368843186516346 0.0111843905243935 1.0 0.5539034810165695 57 P08236,O75381,P38571,O75431,O75844,Q16625,Q04656,O60313,P04062,Q14118,P35670,O00116,O00584,P38435,P23786,P00403,O75845 17 +Progressive neurologic deterioration 0.6234782418050482 2.507816294299149 0.0121479805422757 1.0 0.5539034810165695 19 Q5XKP0,P20700,P04062,P21912,P54802,Q9NPL8,Q10713,Q9NZJ7,P16278 9 +Dysostosis multiplex 0.8489968544801999 2.477920584172689 0.0132150555645849 1.0 0.5539034810165695 7 P04066,P16278,P15586,P54802,P10619 5 +Abnormality of the ribs 0.4461192528094563 2.465178269640592 0.0136945098298952 1.0 0.5539034810165695 64 Q9UM00,Q04656,O95202,Q96L58,P16435,Q96HY6,O96028,P02545,Q7RTS9,P00813,O95831,Q8TAA9,Q9BV10,O75844,O75431,Q32P28,Q5H8A4,Q9UHX1,P16278,P15586,P54802,Q9H0W5 22 +Retinal degeneration 0.4823026765102701 2.4638532869528724 0.013745236138339 1.0 0.5539034810165695 54 O14773,O75503,Q9NW15,Q7LGA3,Q13510,Q9UG56,P51648,P50897,O60313,Q10713,P68371 11 +Abnormal csf metabolite level 0.4636081689247081 2.4472252493926128 0.0143960837950356 1.0 0.5539034810165695 59 P13073,O95169,Q86Y39,O95831,Q9P0J0,Q96CU9,Q9Y6M9,O96000,Q9NPL8,Q7KZN9,O43819,P00846,P00403,Q8IUX1 14 +Respiratory arrest 0.7773560013892435 2.4377415569538825 0.0147793361590695 1.0 0.5539034810165695 9 P23786,Q96L58,P13473 3 +Fluctuations in consciousness 0.7989840321892422 2.436903717690531 0.0148136230895121 1.0 0.5539034810165695 8 P04062,O95169,O43819,P00403 4 +Abnormality of femur morphology 0.4457194668771746 2.43463197149788 0.0149069427934269 1.0 0.5539034810165695 66 Q9Y487,Q7LGA3,Q04656,P04062,Q96L58,P06280,P16435,Q96HY6,Q7RTS9,O95831,Q9NZJ7,Q9BV10,O75844,O75431,Q32P28,Q9UHX1,P04066,P16278,O00116,Q96A33 20 +Disproportionate short limb short stature 0.5980153408884048 2.4341585244124233 0.0149264563364044 1.0 0.5539034810165695 20 Q7LGA3,Q7RTS9,Q32P28,Q9H6U8,O00116,Q9BV10,Q96MF7 7 +Increased csf lactate 0.4823792027093767 2.433032756838991 0.0149729462513292 1.0 0.5539034810165695 53 P13073,O95169,Q86Y39,O95831,Q9P0J0,Q96CU9,Q9Y6M9,O96000,Q9NPL8,Q7KZN9,O43819,P00846,P00403,Q8IUX1 14 +Polyneuropathy 0.5919955863262208 2.4240597081831945 0.0153480818085611 1.0 0.5539034810165695 21 O95831,O60313,O95721,P04066,P35670,Q15041,Q9NZJ7,P00846 8 +Pathologic fracture 0.660494686488253 2.404790889605685 0.0161817221352993 1.0 0.5539034810165695 15 Q14108,P04062,P35670,O15269,Q96L58,O75845 6 +Ventricular hypertrophy 0.5115759658031437 2.396250512104787 0.016563765374161 1.0 0.5539034810165695 40 P06280,Q6NUK1,O43772,O75431,O75844,P10253,P21912,O75880,P02545,O75787,Q9BV10,P23786,P00403,Q96MF7 14 +Abnormal macrophage morphology 0.8893257979320768 2.3835975395652733 0.0171443404386997 1.0 0.5539034810165695 5 P16278,O15118,Q13510 3 +Exercise intolerance 0.5188535351233493 2.382452206076574 0.0171977642344993 1.0 0.5539034810165695 35 P13473,Q53H12,Q9H2D1,Q9Y2R0,P23786,P00403,Q8IUX1 7 +Exaggerated startle response 0.7872081515162436 2.380753099719507 0.0172772876355133 1.0 0.5539034810165695 8 P17900,P16278 2 +Foam cells 0.8552051069210006 2.3780953142657935 0.0174023270195309 1.0 0.5539034810165695 6 P16278,O15118,Q13510,P38571 4 +Arteriosclerosis 0.7036775740972406 2.3679940707210165 0.0178848225219641 1.0 0.5539034810165695 12 Q13510,P38571,O15118,P16278,P38435,O75844 6 +Decreased activity of mitochondrial complex iv 0.6293250763506152 2.3677866548202684 0.0178948515353465 1.0 0.5539034810165695 17 P13073,P20674,Q9Y2R0 3 +Abnormal epiphyseal ossification 0.6414038083377744 2.363718141453353 0.0180925716678714 1.0 0.5539034810165695 16 P08236,Q7RTS9,O75381,Q9UG56,Q96HY6,O00116,P38435,Q96L58 8 +Abnormal tissue metabolite concentration 0.7015351329299528 2.3562281963142495 0.0184615726853061 1.0 0.556543795777979 12 P06280,P17900,O75381,O43681,Q9Y276,P40855,Q9NZJ7,P06865 8 +Diarrhea 0.4426216052665229 2.335130877097729 0.0195365847421584 1.0 0.5642165961853858 71 P06280,Q14566,Q15904,Q5HYI8,Q13510,Q9BT22,P38571,Q13423,Q9H6U8,P00813,Q9UJS0,P15586,P54802,Q96A33,P42892,P00403,P50416 17 +Abnormality of the wrist 0.5295078026134911 2.326311363741058 0.0200019462380542 1.0 0.5642165961853858 30 Q7RTS9,Q13510,P16435,O95831,O94905,P16278,Q9H6K4,Q9BV10,O75844,Q96L58 10 +Muscle spasm 0.4405241030544645 2.3158233960742596 0.0205679132574689 1.0 0.5642165961853858 62 P06280,Q9NR77,P09622,Q9UHD9,P13473,P07196,Q92804,P05023,Q5H8A4,P04062,P00846,P35637,Q15165,Q9H6K4,P23786,O75298 16 +Abnormal mitochondria in muscle tissue 0.5744493948313355 2.300590315795668 0.0214147989431345 1.0 0.5642165961853858 21 Q86Y39,Q96CU9,Q9Y6M9,O96000,P00403,Q8IUX1 6 +Hypocholesterolemia 0.808196662200875 2.292818113750179 0.0218584787242854 1.0 0.5642165961853858 7 Q9NZJ7,P37268,Q9NVI7,Q15800 4 +Undetectable electroretinogram 0.9451220964747116 2.288118607053906 0.0221306149372191 1.0 0.5642165961853858 4 O14773,P50897 2 +Aplasia hypoplasia of toe 0.5112270257217902 2.282153244500133 0.0224802944021635 1.0 0.5642165961853858 32 P13073,Q7LGA3,Q13510,Q5H8A4,P00813,Q9UHX1,Q9NX62 7 +Abnormal csf protein level 0.6879647516689609 2.281312915637529 0.0225299369936755 1.0 0.5642165961853858 12 Q9NR77,P20700,O43681,Q16625,Q9NZJ7,P00403 6 +Decreased absent ankle reflexes 0.6270976511677877 2.2746789395887363 0.022925196771987 1.0 0.5642165961853858 16 P12235,Q13501,O60313,O95140,O75787,Q15120,Q15041,Q9H6K4,P07196 9 +Central scotoma 0.7232772558502123 2.2745045574850473 0.0229356673971301 1.0 0.5642165961853858 10 Q9H6K4,Q9H061,P00846 3 +Impaired vibratory sensation 0.5279438416925785 2.2639035376924235 0.0235800483249113 1.0 0.5642165961853858 29 O14773,Q9NR77,P20700,O94905,O75298,O43819,P07196,P00846 8 +Toe walking 0.5596027066355416 2.2596679190485647 0.023841868799818 1.0 0.5642165961853858 23 Q99720,O43681,O95831,Q8TD16,P02545,Q9NZJ7,P35637,Q9BTV4,P50402 9 +Anencephaly 0.6670408204991123 2.249688725285314 0.0244687117329871 1.0 0.5657806860948441 13 P21964,Q8TAA9 2 +Gait ataxia 0.4324403359286431 2.244829128747029 0.0247791040346849 1.0 0.5657806860948441 69 O14773,P41440,Q9NW15,O15118,Q03252,Q15907,Q14108,Q10713,P04350,P07196,P00846,Q13217,Q9NR77,P12235,Q9Y4W6,Q9NZJ7,Q05086,P20700,Q9NVI7,O43681,Q5H8A4,Q8IV08 22 +Cardiac conduction abnormality 0.5065380459996682 2.242361303205464 0.0249380306598419 1.0 0.5657806860948441 32 P06280,O43772,O95169,O43819,P21912,P02545,Q9BTV4,Q8NC56,P23786,P50402,P00846,P00403 12 +Increased cerebral lipofuscin 0.9319640564826625 2.235041332750403 0.0254146353374453 1.0 0.5657806860948441 4 O14773,P50897,O75503 3 +Myoclonic spasms 0.8187944521352687 2.2167502740787364 0.026640161231211 1.0 0.5657806860948441 6 Q10713 1 +Slowly progressive 0.445456466941422 2.2166346586467753 0.0266480671788833 1.0 0.5657806860948441 58 O14773,Q99720,P41440,Q04656,Q9P0J0,P50402,O14979,P02545,O00584,P07196,Q9NR77,P12235,Q9Y4W6,P05023,Q5JTV8,O95831,O94905,Q9BTV4,Q8IV08,O95140,O75787 21 +Decreased activity of mitochondrial complex i 0.4994601110322776 2.214998803265111 0.0267601466638125 1.0 0.5657806860948441 35 Q70HW3,Q86Y39,Q9Y6M9,Q96CU9,Q9UBX3,O96000,Q8IUX1 7 +Juvenile onset 0.4848922684094325 2.2092077163005213 0.0271601964305325 1.0 0.5693719717469182 43 O14773,Q14566,P41440,P06280,Q9NR77,O75027,Q13510,P38571,O15118,Q03252,Q04656,P02545,P16278,P54802,P07196,P50402 16 +Talipes equinovarus 0.4405097654066728 2.1972939604124906 0.02799945872227 1.0 0.573073922897449 80 Q9Y487,Q9NWM8,Q9UM00,Q9Y3E5,Q15907,O95202,Q96L58,P16435,Q8NCH0,Q9NR77,Q7RTS9,Q8TAA9,Q9BV10,P21964,O75845,P08236,Q5H8A4,Q9H6U8,Q9HC21,Q8TD16,Q96A33 21 +Variable expressivity 0.4400763168530048 2.1923348540753764 0.0283553368189752 1.0 0.573073922897449 80 Q8NI60,Q13510,Q70HW3,Q53H12,P02545,P00374,P04350,P07196,Q9NR77,Q9H061,P17900,Q9Y4W6,Q9NZJ7,P49736,P00403,P09622,Q13885,Q6P4A7,Q9BVA1,O95470,Q9Y276,O95140,Q9NWS8,Q8TD16,Q14118,Q9BUF5 26 +Proximal tubulopathy 0.550444369725388 2.1923180238547255 0.0283565512032257 1.0 0.573073922897449 23 Q86Y39,Q96CU9,Q9Y6M9,O96000,P00403,Q8IUX1 6 +Lower limb spasticity 0.4376983546715497 2.1901549683040544 0.0285129998476438 1.0 0.573073922897449 78 Q99720,Q5XKP0,P35637,Q9H6U8,O95831,Q9P0J0,Q96CU9,O60313,O75298,Q7KZN9,P21912,P04062,O94905,Q9NZJ7,Q9H6K4,Q15041,P00846,Q6DKK2 18 +Abnormality of fontanelles 0.4825365052872288 2.187298604557165 0.0287207325442637 1.0 0.573073922897449 43 Q9Y487,Q6NUK1,P20674,O75381,Q9BT22,Q16134,Q32P28,P98175,P16435,Q9H6U8,Q04656,P40855,P02545,Q8NCH0,O75844 15 +Abnormal biliary tract morphology 0.5447294750540428 2.184852125565246 0.0288996906912173 1.0 0.573073922897449 24 Q14108,Q5XKP0,Q9Y276,P09601,Q10713,Q9NZJ7 6 +Cardiorespiratory arrest 0.8402527463917451 2.17314948346933 0.0297690684161886 1.0 0.573073922897449 5 Q96L58,P13473 2 +Aplasia hypoplasia involving the vertebral column 0.6102910951175727 2.168873203319524 0.0300923116665479 1.0 0.573073922897449 16 P08236,Q7RTS9,Q14739,Q96HY6,Q15738,O95831,P04066,P16278,Q8TAA9 9 +Sensory neuropathy 0.4926522772898722 2.1678737693226657 0.0301682921209989 1.0 0.573073922897449 36 Q15067,Q8IV08,O95831,O60313,O94905,P22626,Q15041,O15269,P00846,P00403 10 +Nephrotic syndrome 0.5039539621680125 2.166620993189042 0.0302637653189108 1.0 0.573073922897449 31 P06280,Q14108,Q9BT22,O95470,P00813,Q8NCH0 6 +Biliary tract abnormality 0.5210851509572568 2.162507330127477 0.0305790927009883 1.0 0.573073922897449 28 Q14108,Q5XKP0,Q9Y276,P04062,P09601,Q10713,Q9NZJ7 7 +Abnormality of glycolipid metabolism 0.8063583815028765 2.1609468904543685 0.0306994421844919 1.0 0.573073922897449 6 P06280,P17900,O43681,Q9NZJ7,P06865 5 +Splenomegaly 0.4404583064177704 2.1594508743983183 0.030815204637733 1.0 0.573073922897449 83 Q9BT22,Q16625,O15118,P04062,Q15392,Q14108,Q13510,Q10713,Q15904,P00813,P35670,Q9NZJ7,P21964,P08236,Q9NZ08,P38571,P10253,P04066,P16278,P15586,P54802,Q96A33 22 +Delayed cranial suture closure 0.5086872386237017 2.1554455300355224 0.0311269867409369 1.0 0.573073922897449 30 Q9Y487,O75381,O75431,Q32P28,P16435,Q9H6U8,Q04656,P40855,P02545,Q8NCH0,O75844 11 +Chronic pulmonary obstruction 0.8338517168742399 2.1453333252656734 0.0319262058280396 1.0 0.573073922897449 5 P09601,P21964 2 +Osteoarthritis 0.697302466516427 2.1384538423353425 0.0324799265416884 1.0 0.573073922897449 10 Q14108,Q96HY6,P04062,P35670,O75844 5 +Progressive gait ataxia 0.661101112378553 2.131015629702705 0.0330878545771822 1.0 0.573073922897449 12 O14773,Q9NW15,Q05086,Q9NZJ7,P00846 5 +Diffuse white matter abnormalities 0.6955815950864256 2.1293630548663995 0.0332242346430884 1.0 0.573073922897449 10 O95169,O75306,Q9H9S5,P16278,Q3ZCQ8,O43819 6 +Left ventricular hypertrophy 0.5325273962227263 2.129156512436166 0.0332413134939286 1.0 0.573073922897449 25 P06280,P12235,Q6NUK1,O75431,P10253,P21912,O75880,O75787,P00403 9 +Abnormal brainstem mri signal intensity 0.5539512655698193 2.125355315917284 0.0335569758273168 1.0 0.573073922897449 20 Q86Y39,Q96CU9,Q9Y6M9,O96000,Q9NPL8,Q8IUX1 6 +Abnormal sella turcica morphology 0.771825921405848 2.1242795911592567 0.0336467712604742 1.0 0.573073922897449 7 P08236,Q7RTS9,P16278 3 +Impaired social interactions 0.4670657046879573 2.123095484927156 0.033745851300369 1.0 0.573073922897449 47 Q5XKP0,O75746,Q86Y39,Q9GZY8,Q9UHX1,Q9P0J0,Q96CU9,Q9Y6M9,O96000,Q9NPL8,Q15907,Q15067,Q8IUX1 13 +Hypersplenism 0.7953903093047439 2.1114370719367925 0.0347347614401767 1.0 0.5739691881755238 6 Q9NZJ7,Q14108,P38571 3 +Abnormal circulating copper concentration 0.7952878731868134 2.110973381263219 0.0347745998931929 1.0 0.5739691881755238 6 O43819,Q9Y487,Q15904 3 +Mania 0.642875864886639 2.10994119362818 0.0348634214667571 1.0 0.5739691881755238 13 P16615,P21964,P00403 3 +Microcytic anemia 0.7117755063514601 2.108907264234281 0.0349525870636842 1.0 0.5739691881755238 9 Q9UBX3,P22830,O75027 3 +Macroglossia 0.4857427117608204 2.106688475005773 0.0351445918609547 1.0 0.5739691881755238 36 P07686,Q7LGA3,Q05086,Q9H9S5,P10253,O94905,P04066,P21912,Q96S52,O75648,P16278,Q10713,Q96A33,Q9Y4P3 14 +Loss of speech 0.5641670643320628 2.105853236873168 0.0352171027802068 1.0 0.5739691881755238 19 P17900,P50897,O15118,O94905,Q9NZJ7,Q9UQN3 6 +Abnormal ldl cholesterol concentration 0.6693982292516865 2.099400954136971 0.0357815706647357 1.0 0.5743817864398666 11 P38571,Q15800,Q9UJS0,Q9BTV4,P37268,P50402 6 +Impaired vibration sensation in the lower limbs 0.6544131225381117 2.0931831385867476 0.0363328093328849 1.0 0.5755575740023312 12 Q9NR77,O43819,O75298,P00846 4 +Mitochondrial inheritance 0.8213894369716477 2.0909374470609725 0.0365336717144115 1.0 0.5755575740023312 5 P00846,P00403 2 +Mixed demyelinating and axonal polyneuropathy 0.8211315774339011 2.0898085939896425 0.0366349970575419 1.0 0.5755575740023312 5 P07196,P00403 2 +Arrhinencephaly 0.7080403776575562 2.0897896169511436 0.0366367024721363 1.0 0.5755575740023312 9 Q8TAA9 1 +Increased serum pyruvate 0.4863025638886271 2.078076873769358 0.0377022793047816 1.0 0.5755575740023312 33 Q70HW3,Q86Y39,Q9Y276,P22695,Q96CU9,Q9Y6M9,P21912,O96000,Q9BWD1,Q9NPL8,Q5JRX3,Q8IUX1 12 +Flat face 0.5350615086715149 2.078023789748805 0.0377071680614389 1.0 0.5755575740023312 23 P08236,Q9Y487,O75381,P07437,Q9UM00,P40855,Q9NX62,Q96L58 8 +Progressive psychomotor deterioration 0.7610513942281498 2.073708997360514 0.0381063451146557 1.0 0.5755575740023312 7 O43681,P21912,P16278,Q10713,Q9NZJ7 5 +Elevated pulmonary artery pressure 0.5344727945683664 2.0736204524138246 0.0381145742113262 1.0 0.5755575740023312 23 P20674,Q14108,P04062,O96000,O75844,P00403 6 +Cutis laxa 0.4846025274420919 2.073479664611144 0.0381276617108365 1.0 0.5755575740023312 34 Q9Y487,Q6NUK1,Q9BV10,Q9Y4P3,Q04656,O96000,Q9NX14,Q8NCH0,P38435,Q96L58,Q15904 11 +Abnormality of visual evoked potentials 0.5425409061489957 2.0714425219971413 0.0383174606223137 1.0 0.5755575740023312 21 O75503,O43681,Q9GZY8,O60313,O95140,Q9NZJ7,Q15067 7 +Capillary hemangioma 0.7603618621668662 2.070462672585539 0.0384090380983861 1.0 0.5755575740023312 7 Q7LGA3,Q9UHX1 2 +Psychomotor deterioration 0.7598294234611718 2.0679551242703336 0.0386442431191011 1.0 0.5755575740023312 7 Q9Y487,P50897,Q9NZJ7 3 +Abnormal tongue morphology 0.4192963962304759 2.0669565681150126 0.0387382466492529 1.0 0.5755575740023312 71 Q7LGA3,Q6NUK1,Q9H9S5,P98175,Q03252,P61978,P21912,Q96S52,P02545,Q10713,P07196,O60826,O94905,O43924,O75844,Q9Y4P3,P07686,Q05086,P20700,O75431,P10253,O75648,P04066,P16278,Q96A33 25 +Abnormality of extrapyramidal motor function 0.4253216575017993 2.0599941367512544 0.0393991013437338 1.0 0.5815624968897981 77 Q99720,P98175,Q9H9P8,P04062,O14949,P35637,O75569,Q709C8,P02792,Q13501,Q9H6K4,Q96IX5,Q9UQN3,P12235,P17900,Q9Y4W6,Q15043,Q9NZJ7,Q9BPX6,Q9Y4P3,P07686,P16278,O75787,O96008,P06865,Q6DKK2 26 +Abnormality of the mitochondrion 0.447133343549757 2.055210061871864 0.0398587196973971 1.0 0.5846370036126213 98 Q16134,Q9P0J0,Q9Y2R0,O75880,Q3ZCQ8,Q7KZN9,P35637,P23786,P13073,O43772,Q70HW3,Q86Y39,Q96CU9,P21912,O96000,Q4J6C6,P00846,P20674,P12235,O75306,Q9Y4W6,Q9GZY8,Q9Y6M9,Q9UBX3,Q9NX14,P00403,Q8IUX1,P09622,Q16836,Q9BUB7,Q9NPL8 31 +Fasciculations 0.4727886702333648 2.0452464387113234 0.0408305682812366 1.0 0.5897341214450889 40 P06280,P07686,Q9NW15,Q13510,Q969X5,Q9BQT8,Q13501,O95831,P22626,Q8TD16,Q9NWS8,Q9NZJ7,P35637,O43819,P07196,Q9UQN3 16 +Abnormal left ventricle morphology 0.4954427002602059 2.045036976342436 0.0408512128124287 1.0 0.5897341214450889 30 P06280,Q15645,Q6NUK1,P12235,O75431,Q9H6U8,P10253,P21912,O75880,O75787,P00403 11 +Retinopathy 0.5163481999458558 2.0417698704292166 0.0411743642675035 1.0 0.5897341214450889 26 Q5JRA6,O95169,Q9NZ08,Q5H8A4,P51648,P07437,O96028,O43819,O95202,P00846 10 +Dysdiadochokinesis 0.590272680714085 2.0411383928485343 0.0412370731844551 1.0 0.5897341214450889 16 O75503,P41440,P20700,O75027,Q9Y4W6,P04350,Q6DKK2 7 +Ascites 0.5110751590011006 2.0397900606312427 0.0413712402082204 1.0 0.5897341214450889 27 P08236,Q15645,Q14108,Q13510,P38571,Q9H6U8,O15118,P04062 8 +Abnormality of epiphysis morphology 0.4319841186134945 2.0373094719062306 0.0416190392449167 1.0 0.5897341214450889 57 P08236,Q7LGA3,Q7RTS9,O75381,Q9UG56,P38435,P16435,Q96HY6,Q04656,O95831,Q9Y2U8,P16278,O00116,O95202,Q96L58,Q96MF7 16 +Saccadic smooth pursuit 0.8835628490367747 2.03730763151674 0.0416192235565691 1.0 0.5897341214450889 4 O14773,Q10713 2 +Scotoma 0.6299958252894631 2.034521689142343 0.0418990240658738 1.0 0.59050948557933 13 Q9H6K4,Q9H061,P00846 3 +Dysmetria 0.4314783966726012 2.0318336895853903 0.0421704953508343 1.0 0.59050948557933 57 O14773,O75503,Q9NW15,P20700,O75027,Q6P4A7,Q6DKK2,Q8IV08,Q9Y3E5,O60313,O75787,Q10713,Q9NPL8,Q5JRX3,Q9Y4P3 15 +Abnormality of skull ossification 0.6292151277507577 2.0299294310065688 0.0423637129823017 1.0 0.59050948557933 13 Q6NUK1,Q32P28,Q9H6U8,Q9HC21,P02545,P54802,O75844 7 +Atlantoaxial abnormality 0.8060357986402753 2.0234884176802925 0.0430228165246668 1.0 0.59050948557933 5 Q8NCH0,Q7RTS9,Q96L58 3 +Retinal dysplasia 0.6756667416824023 2.023461430850197 0.0430255961947225 1.0 0.59050948557933 10 O43505,P07437,O43924,Q14118,Q10713 5 +3 methylglutaconic aciduria 0.6415413883571304 2.0199052915621567 0.0433932123117002 1.0 0.59050948557933 12 Q5XKP0,Q9NVI7,Q53H12,Q3ZCQ8,Q9H6K4 5 +Urinary glycosaminoglycan excretion 0.7495910405968813 2.0195979834262157 0.0434251045053044 1.0 0.59050948557933 7 P04066,P16278,P15586,P54802 4 +Focal t2 hyperintense brainstem lesion 0.5748337966511299 2.0141981285464796 0.0439887361064197 1.0 0.59050948557933 17 Q86Y39,Q9Y6M9,Q96CU9,O96000,Q8IUX1 5 +Abnormal cardiac ventricular function 0.5629996869087325 2.01320687602797 0.0440928701762866 1.0 0.59050948557933 18 P09622,P12235,Q9H9S5,P10253,P21912,P02545,O75844,P00403 8 +Arthritis 0.4706916873537032 2.011020600670185 0.04432328079859 1.0 0.59050948557933 39 P06280,P10321,Q14108,Q13510,Q9NZ08,P04062,Q9Y2U8,P35670,P21964,O75844 10 +Dyschromatopsia 0.7113611331399144 2.009817102805463 0.0444505499739098 1.0 0.59050948557933 8 Q9H6K4,Q9H061 2 +Ovoid vertebral bodies 0.7110442049510983 2.0082333557438057 0.0446185000308458 1.0 0.59050948557933 8 P16278,P15586,P54802 3 +Abnormality of pulmonary circulation 0.5061857883495445 2.000684102023383 0.0454264437552698 1.0 0.5958651522298394 27 P20674,Q14108,Q9NZ08,P04062,O96000,O75844,P00403 7 +Episodic vomiting 0.6704323720546258 1.995413658558436 0.0459977824722748 1.0 0.5999313049153797 10 P00846,P00403 2 +Amyotrophic lateral sclerosis 0.5600615410756762 1.9931777611565624 0.0462419853941964 1.0 0.6005421069360933 18 Q99720,Q9UHD9,Q92804,P35637,Q15165,Q9UQN3 6 +Abnormal saccadic eye movements 0.4999458299041032 1.9917311357937064 0.0464005655735264 1.0 0.6005421069360933 28 O14773,Q9NW15,Q8IV08,P04062,Q10713,O43819 6 +Global brain atrophy 0.5312860397942041 1.9891843810988017 0.0466808552319131 1.0 0.6005421069360933 21 O95169,O75306,Q9H6U8,Q13501,Q9UHX1,Q9H9P8,Q9NZJ7,P35637,O43819 9 +Abnormal visual electrophysiology 0.4408187131829469 1.9826968904798856 0.0474012971414743 1.0 0.6005421069360933 52 O14773,O75503,P12235,O43681,P50897,Q53H12,Q9GZY8,O60313,P00846,O95140,O43924,Q13099,Q9NZJ7,Q8WWY3,Q15067 15 +Coarse hair 0.53397322956824 1.981678411554616 0.0475152449331288 1.0 0.6005421069360933 20 Q9Y487,Q6NUK1,Q9UM00,Q9Y276,P15586,P54802,Q96A33 7 +Central apnea 0.7043174373260083 1.9745526612675353 0.0483189356989171 1.0 0.6005421069360933 8 Q10713,Q9NZJ7 2 +Airway obstruction 0.6194807965153077 1.9724699189615489 0.0485559869779932 1.0 0.6005421069360933 13 P06280,P16435,Q96HY6,P09601,P21964,O75844 6 +Ventricular arrhythmia 0.4628786675408549 1.9687658815328464 0.0489799819267773 1.0 0.6005421069360933 41 O43772,P12235,P13473,P10253,P21912,P42892,P02545,Q9NX14,Q9BTV4,P23786,P50402,P00846,P00403 13 +Abnormal larynx physiology 0.5678239872076285 1.9676616264831548 0.0491069838622217 1.0 0.6005421069360933 17 Q13510,Q9UHD9,Q92804,P35637,Q15165 5 +Abnormal renal tubule morphology 0.5019875427352682 1.9669731595012157 0.0491863052026229 1.0 0.6005421069360933 27 P06280,Q9Y276,O43819,P23786,P00846 5 +Abnormality of lipoprotein cholesterol concentration 0.6322294885006512 1.9665124262922449 0.0492394483527891 1.0 0.6005421069360933 12 P38571,Q15800,Q9UJS0,Q9BTV4,P37268,P50402 6 +Oligosacchariduria 0.8664515179058955 1.9664892023173732 0.0492421283910364 1.0 0.6005421069360933 4 P04066,P16278 2 +Positive romberg sign 0.6649770938434089 1.966088261300927 0.0492884161390096 1.0 0.6005421069360933 10 Q9H6K4,P07196,Q8IV08,O95140 4 +Generalized hyperkeratosis 0.7927923205359808 1.9649303250751888 0.0494223023142359 1.0 0.6005421069360933 5 P04066,P21912,O75844 3 +Eeg with focal spikes 0.7631243631076544 1.9642047419462465 0.0495063531295849 1.0 0.6005421069360933 6 O75503 1 +Premature rupture of membranes 0.7628387463221185 1.9628909899806224 0.0496588419310182 1.0 0.6005421069360933 6 Q8NC56,Q9Y487,O75844 3 +Abnormal blood transition element cation concentration 0.6315275333973721 1.9624746129335493 0.0497072534601863 1.0 0.6005421069360933 12 O43819,Q9Y487,Q9Y276,Q15904 4 +Abnormal rib cage morphology 0.4155881834840257 1.95909397228377 0.0501017825960714 1.0 0.6022164363736321 76 Q9UM00,Q04656,O95202,Q96L58,P16435,Q7RTS9,P00813,O95831,Q8TAA9,Q9BV10,O75844,P08236,O75431,Q32P28,Q5H8A4,Q9UHX1,P04066,P16278,P15586,P54802 20 +Abnormal femoral head morphology 0.5304014012368321 1.955748628703527 0.0504947731499871 1.0 0.6022164363736321 20 Q7LGA3,Q7RTS9,O75431,O95831,P16278,Q96L58 6 +Abnormal full field electroretinogram 0.7003398842448398 1.95457818431335 0.0506328783359228 1.0 0.6022164363736321 8 P50897,P00846 2 +Abnormal light and dark adapted electroretinogram 0.7003398842448398 1.95457818431335 0.0506328783359228 1.0 0.6022164363736321 8 P50897,P00846 2 +Abnormal lower motor neuron morphology 0.6807625041897587 1.9489030471833015 0.0513070041138792 1.0 0.6062776689089822 9 P35637,Q99720,Q13510 3 +Abnormal nephron morphology 0.4033273859484955 1.9451270179358695 0.0517596928668262 1.0 0.6062776689089822 66 P06280,Q14108,Q8NFH4,O95169,O43819,Q9NZ08,O75431,O95470,Q9Y276,Q03252,P00813,P21912,P02545,Q8N1F7,P23786,P00846,P00403,Q9Y4P3 18 +Basal ganglia cysts 0.7336363262408776 1.9437176959041176 0.051929503478258 1.0 0.6062776689089822 7 P00846 1 +Insidious onset 0.7880040196760518 1.943672809963369 0.0519349194788858 1.0 0.6062776689089822 5 P04062,O60313 2 +Dilated cardiomyopathy 0.4564604135199256 1.9413147154983303 0.0522201156954598 1.0 0.6062776689089822 43 P12235,O95169,O75306,P13473,Q16836,P02545,P42167,Q9NX14,Q9BTV4,O43819,P16278,P23786,P00846,P00403 14 +Skeletal muscle hypertrophy 0.4435715085741615 1.9362066973525136 0.0528423905464674 1.0 0.6095462688412866 49 Q9NR77,P07686,Q7LGA3,Q05086,Q9H9S5,P10253,P20936,O94905,P21912,Q96S52,P04066,P02545,Q10713,O75648,Q14118,P16278,Q96A33,Q9Y4P3 18 +Abnormal large intestine physiology 0.5623971656944978 1.9314701397192493 0.0534249385590432 1.0 0.6131847323114193 17 P06280,P20700,Q8TAA9,Q9NZJ7,P21964,O75298 6 +Insulin resistance 0.5494867915924431 1.9207240515445472 0.0547665057454433 1.0 0.6188361749349401 18 O75431,Q8NC56,Q03252,O95140,O76024,P02545,P18031,O75844,P31751,Q96MF7 10 +Lower limb pain 0.7284754540380538 1.919036930796933 0.0549796602062588 1.0 0.6188361749349401 7 O75569,O75477,P20936,O95140,P00846 5 +Abnormal corpus striatum morphology 0.537476639721002 1.918759143222481 0.0550148227183853 1.0 0.6188361749349401 19 O95169,Q9BVA1,P02792,O95831,O43819,P00846 6 +Severe short stature 0.5139453778370793 1.9187375525462664 0.0550175564637596 1.0 0.6188361749349401 23 Q7RTS9,Q96HY6,P10619,P21912,Q15392,P16278,Q96L58,Q96MF7 8 +Abnormal auditory evoked potentials 0.7532063238029587 1.9184786663866584 0.0550503446587857 1.0 0.6188361749349401 6 P07196,Q9NZJ7,O60313 3 +Skin nodule 0.5210620846124641 1.9138137905836567 0.0556439527811825 1.0 0.6188361749349401 21 P06280,P16615,Q13510,Q9NZ08,P21912,Q9Y2U8 6 +Nephropathy 0.5172613147074923 1.913677911287835 0.0556613231188427 1.0 0.6188361749349401 22 P06280,P00403,Q14108,Q10713 4 +Abnormal sensory nerve conduction velocity 0.7504861165093144 1.9058994619453056 0.0566632508870419 1.0 0.6188361749349401 6 Q9NR77,O15269,Q9Y3E5 3 +Generalized joint laxity 0.6342582154760391 1.903816904656698 0.0569340341291741 1.0 0.6188361749349401 11 Q8NCH0,Q9Y487 2 +Abnormal social behavior 0.4040133928626366 1.9003894755314044 0.0573820270313232 1.0 0.6188361749349401 62 Q5XKP0,O43681,O75746,Q86Y39,Q9Y4P3,Q9GZY8,Q9UHX1,Q9P0J0,Q96CU9,Q9Y6M9,O96000,Q9NPL8,Q9NX14,Q9NZJ7,Q15907,Q15067,Q8IUX1 17 +Abnormal retinal vascular morphology 0.4375209863097938 1.8983105962514677 0.0576551789331096 1.0 0.6188361749349401 50 P17900,Q13510,P38435,P21912,P16278,Q9NZJ7,P21964,P10619,P00846 9 +Muscle stiffness 0.5462077931975767 1.898141639585914 0.057677426212316 1.0 0.6188361749349401 18 Q9NW15,P23786,P00846,Q9NZJ7 4 +Blindness 0.4157264483890638 1.897171226283742 0.0578053431138272 1.0 0.6188361749349401 81 O43505,P17900,Q86Y39,P50897,Q96CU9,Q9Y6M9,P21912,O96000,P16278,Q9NPL8,Q9NZJ7,Q9H6K4,P06865,P00846,Q8IUX1 15 +Difficulty walking 0.4153937162563934 1.8932545256047564 0.0583240294280862 1.0 0.6188361749349401 81 O14773,Q99720,Q15041,P35637,Q15907,O75298,Q13510,O75477,P00846,Q9NR77,Q7RTS9,P35670,Q9NZJ7,Q9BPX6,O43681,Q9HC21,Q8TD16,Q14118,Q15067 19 +Limb pain 0.6320149436204939 1.8911856886663785 0.0585995610779312 1.0 0.6188361749349401 11 O75569,O75477,P20936,O95140,O15269,P00846 6 +Incoordination 0.4053732984823847 1.8903284662736397 0.0587140439187103 1.0 0.6188361749349401 72 O14773,Q01105,O75503,Q9NR77,Q7RTS9,Q05086,Q13510,O43681,P04062,P21912,O95140,Q10713,P35670,O43819,Q9NZJ7,P00846,Q15067,Q6DKK2 18 +Periventricular white matter hyperintensities 0.7470236053735071 1.889864100258829 0.0587761379429789 1.0 0.6188361749349401 6 O75503,P17900,Q9NZJ7 3 +Phenotypic variability 0.4376752239685778 1.8874085255052768 0.0591053993084966 1.0 0.6188361749349401 103 Q92733,Q8WWY3,Q8NI60,Q13510,Q70HW3,Q53H12,O14979,P21912,P02545,P00374,P04350,P07196,P00846,Q9NR77,Q9H061,P17900,Q9Y4W6,O60313,Q9NZJ7,P49736,P00403,P09622,Q13885,Q6P4A7,Q9BVA1,O95470,Q9Y276,O95140,Q9NWS8,Q8TD16,Q14118,Q9BUF5 32 +Waddling gait 0.5006765124741264 1.881873751951188 0.0598531590508712 1.0 0.6188361749349401 25 Q7RTS9,Q13510,P22626,Q8TD16,P02545,Q14118,Q4J6C6,P07196,Q9BTV4,P50402 10 +Abnormal circulating fatty acid concentration 0.5322165206037809 1.8814318128850296 0.059913202718087 1.0 0.6188361749349401 19 P09622,O43772,O75381,O75431,Q16836,P40855,O75880,P23786 8 +Fetal distress 0.5090327038471761 1.8812836277568323 0.059933346941581 1.0 0.6188361749349401 23 Q9NVI7,Q86Y39,Q96CU9,Q9Y6M9,O96000,Q8IUX1 6 +Abnormal waist to hip ratio 0.7205322683073876 1.8809217687722348 0.0599825615043587 1.0 0.6188361749349401 7 P18031,P43304,O76024,P31751 4 +Sensory ataxia 0.773530156522031 1.8791454962049492 0.0602246293728763 1.0 0.6188361749349401 5 Q9NR77,P54802 2 +Peripheral axonal neuropathy 0.4171521114003941 1.8754469174281447 0.0607312657151053 1.0 0.6188361749349401 57 Q9BPX6,Q15067,P12235,Q9NVI7,Q9Y4W6,Q8IV08,O95831,O60313,P22626,Q9HC21,O95140,O76024,Q9NZJ7,O15269,P07196,P00846,P00403 17 +Hypothermia 0.6164392916157835 1.8752479331109944 0.0607586226670797 1.0 0.6188361749349401 12 O43772,Q5XKP0,P00846,Q04656 4 +Brisk reflexes 0.5119251289185589 1.873542419413714 0.060993520800801 1.0 0.6188361749349401 22 Q99720,Q9NW15,P20674,Q8NI60,Q10713,P35637,Q5JRX3 7 +Abnormal circulating carbohydrate concentration 0.4566544380816135 1.8681271705290663 0.0617443471564165 1.0 0.6188361749349401 38 Q70HW3,Q86Y39,Q9Y276,P22695,Q96CU9,Q9Y6M9,P21912,O96000,Q9UJS0,Q9BWD1,Q9NPL8,Q5JRX3,Q8IUX1 13 +Abnormal glycosylation 0.518100668249278 1.8658921744115495 0.0620564526890028 1.0 0.6188361749349401 20 Q9H0U3,Q9Y487,Q10471,Q9BT22,P46977,P51571,O75787,Q15904 8 +Visual loss 0.4317607586967874 1.8633522454610671 0.0624127240561009 1.0 0.6188361749349401 51 O14773,O75503,P50897,O60313,Q10713,P00846,P00403 7 +Abnormal visual fixation 0.7411387925314988 1.862550752656289 0.0625254985915908 1.0 0.6188361749349401 6 Q13510 1 +Hyperactive patellar reflex 0.6820988991803343 1.862418632515936 0.0625441048071906 1.0 0.6188361749349401 8 P13073,P21912 2 +Abnormality of the achilles tendon 0.5720555762874865 1.8567158536619417 0.0633515907652781 1.0 0.6227990432620817 15 Q9Y3E5,O60313,Q8TD16,P02545,Q15041,Q9BTV4,P50402 7 +Gowers sign 0.6129518446662412 1.8549688948310017 0.0636006685518157 1.0 0.6233855257801306 12 P07196,Q8TD16,Q13510 3 +Wide anterior fontanel 0.5130577414240449 1.854378563401946 0.0636850194523745 1.0 0.6233855257801306 21 Q9Y487,Q6NUK1,P20674,O75381,Q16134,Q32P28,P16435,Q9H6U8,P40855 9 +Deformed sella turcica 0.7677903127969455 1.8534450104040152 0.0638186009838077 1.0 0.6233855257801306 5 P08236,Q7RTS9 2 +Paroxysmal involuntary eye movements 0.5274346512985716 1.8473693829171944 0.064693623423816 1.0 0.6273257411592721 19 Q86Y39,Q96CU9,Q9Y6M9,O96000,Q8IUX1 5 +Lacticaciduria 0.7375763344681441 1.8459797722365736 0.0648951425396506 1.0 0.6273257411592721 6 O96000,P00846 2 +Impaired glucose tolerance 0.7661102317995441 1.8459105817855104 0.0649051899478663 1.0 0.6273257411592721 5 O76024,Q96MF7 2 +Cardiovascular calcification 0.6785351250008945 1.844307468690829 0.0651383436610606 1.0 0.6280331800161433 8 P04062,O75844,O75431 3 +Elevated circulating alanine aminotransferase concentration 0.610497793250423 1.8406726098518191 0.0656695501154474 1.0 0.6284381514517897 12 P38571,Q96MF7,O75880,Q15904 4 +Chronic diarrhea 0.5376141598915282 1.8386983104772716 0.0659595720642889 1.0 0.6284381514517897 18 P00813,Q96A33,Q13510,Q9BT22 4 +Hypolipoproteinemia 0.7117305137896034 1.838506210576776 0.065987847546229 1.0 0.6284381514517897 7 P38571,Q15800,P02545,Q9UJS0,P37268 5 +Abnormal metabolic brain imaging by mrs 0.5481841624331254 1.836009301080608 0.066356281062571 1.0 0.6294249718145947 17 O43819,P21912,P00403,Q9NZJ7 4 +Emg chronic denervation signs 0.5962722669114334 1.8339933607832233 0.0666549796870861 1.0 0.630954663388479 13 Q13510,O43681,O60313,P22626,Q9NZJ7,O43819 6 +Ventricular preexcitation 0.6761164198506232 1.8319960765043093 0.0669520051582388 1.0 0.6324622544886308 8 P00403,P00846,P13473 3 +Occipital meningocele 0.8333106643030224 1.8280432520372307 0.0675430606147968 1.0 0.635409168259333 4 Q10713 1 +Progressive spastic paraplegia 0.4890677418839818 1.8250006701945645 0.0680009282039022 1.0 0.635409168259333 26 Q96CU9,P00846,O75298,Q9P0J0 4 +Myoclonus 0.4272705194687803 1.8246654562931264 0.0680515291181227 1.0 0.635409168259333 98 O14773,P13073,O75503,Q14108,Q01105,Q13510,Q9NQZ5,P50897,Q96CU9,P04062,P00374,Q9UBX3,Q9NPL8,Q10713,Q9NZJ7,P00846,P00403 17 +Abnormal neuron morphology 0.4746198069318982 1.8243817263819504 0.0680943826581554 1.0 0.635409168259333 29 Q99720,Q9UHD9,Q13510,Q92804,O94905,P35637,Q15165,Q9UQN3 8 +Frequent falls 0.4498975496015272 1.818134950172506 0.0690435093123353 1.0 0.6402276854183261 39 Q9NR77,Q7RTS9,Q13510,O43681,P04062,P21912,O95140,Q9NZJ7,O43819,P00846 10 +Abnormal circulating pyruvate family amino acid concentration 0.5045392011352475 1.817709253776768 0.0691085826357373 1.0 0.6402276854183261 22 P20674,Q5XKP0,P22695,Q9P0J0,O96000,O75880,P00846,Q8IUX1 8 +Distal arthrogryposis 0.7597824962090675 1.817486116013743 0.0691427123138683 1.0 0.6402276854183261 5 Q8NCH0 1 +Limitation of joint mobility 0.4266442448447651 1.817317081695062 0.0691685759023066 1.0 0.6402276854183261 98 Q7LGA3,Q9BT22,Q04656,P23786,Q96L58,P50402,P51648,P16435,O14979,Q9Y2U8,Q9H6K4,Q7RTS9,O94905,Q8TAA9,P37268,O75844,Q9BTV4,Q9Y4P3,P08236,Q05086,O75431,Q9HC21,O76024,P16278,P15586,P54802,Q8TD16 27 +Abnormal morphology of the conjunctival vasculature 0.706892928930207 1.815113864668622 0.0695064129411948 1.0 0.6418009266708468 7 P06280,P04066,P10619 3 +Redundant skin 0.4784010903626359 1.8143871946922223 0.0696181358052889 1.0 0.6418009266708468 28 Q9Y487,Q6NUK1,Q9BV10,Q04656,O96000,Q9NX14,Q8NCH0,P38435 8 +Corneal dystrophy 0.7585303675496733 1.8118526984295036 0.0700089598607291 1.0 0.6441104904220596 5 P06280,Q53H12 2 +Decreased circulating iga level 0.7057142018117364 1.8094055368148545 0.0703880236204452 1.0 0.6450128072683917 7 P00813 1 +Abnormal caudate nucleus morphology 0.5910533061817979 1.802569539455548 0.0714558444201673 1.0 0.651311958156721 13 O95169,Q9BVA1,P02792,O43819,P00846 5 +Oromandibular dystonia 0.7279664266705459 1.8011432096769706 0.071680310695807 1.0 0.651311958156721 6 Q99720,Q15043 2 +Extrapyramidal muscular rigidity 0.7279060833006987 1.8008610487160956 0.0717247836846 1.0 0.651311958156721 6 Q9H6K4,Q9BPX6 2 +Barrel shaped chest 0.7554215991943227 1.7978536671541436 0.072200200110474 1.0 0.651311958156721 5 Q32P28,Q7RTS9 2 +Neuronal loss in central nervous system 0.5902461941481698 1.7977006438652556 0.0722244593467895 1.0 0.651311958156721 13 O15118,P04062,Q9NZJ7,P35637,O43819 5 +Paresthesia 0.5012550591891326 1.7927790895358642 0.0730082543271244 1.0 0.6528694391969805 22 P06280,Q9NR77,Q9NZ08,P54802,Q9H6K4,P07196 6 +Spastic paraparesis 0.5076767776387988 1.7890733649090196 0.0736030010470529 1.0 0.6528694391969805 20 Q5XKP0,P04062,P21912,O75787,Q9H6K4,Q6DKK2 6 +Motor neuron atrophy 0.4927309386513424 1.7863685616616678 0.0740396024456289 1.0 0.6528694391969805 24 Q99720,Q9UHD9,Q13510,Q92804,P35637,Q15165,Q9UQN3 7 +Broad ribs 0.72428929502445 1.7839352427112594 0.0744341883839074 1.0 0.6528694391969805 6 Q7RTS9,P16278 2 +Segmental peripheral demyelination remyelination 0.7240930873152003 1.7830162478022735 0.0745836584939094 1.0 0.6528694391969805 6 P07196,P00846 2 +Abnormally lax or hyperextensible skin 0.4318305125563205 1.7747680800638408 0.0759361888836289 1.0 0.6528694391969805 47 Q9Y487,Q6NUK1,Q9BV10,Q9NWM8,P07437,Q9Y4P3,Q04656,Q9UHX1,P04062,O96000,Q9NX14,Q8NCH0,P38435,Q96L58,Q15904 15 +Hypertrophic cardiomyopathy 0.4397440868903955 1.7745698712553266 0.0759689356666126 1.0 0.6528694391969805 115 Q5XKP0,Q9P0J0,Q7KZN9,P50402,P50416,P06280,O95169,Q86Y39,Q53H12,Q96CU9,P21912,O96000,Q96IX5,P00846,Q9H061,O60313,Q9Y6M9,O43819,P00403,Q8IUX1,P09622,Q9NVI7,P13473,Q13423,Q9Y276,P16278,Q9NPL8,P54802,P15586 29 +Schizophrenia 0.5590922872514928 1.773497460381485 0.0761463123405217 1.0 0.6528694391969805 15 P16615,P21964,O76024,Q9NZJ7 4 +Hypoketotic hypoglycemia 0.6645580498478701 1.772947565985104 0.0762373957693618 1.0 0.6528694391969805 8 O43772,Q16836,P23786,P50416 4 +Loss of subcutaneous adipose tissue in limbs 0.8196405648266936 1.7704678666287426 0.0766492327874375 1.0 0.6528694391969805 4 O75844,Q03252,O75431 3 +Upper airway obstruction 0.8196405648266903 1.7704678666287306 0.0766492327874395 1.0 0.6528694391969805 4 O75844,P16435,Q96HY6 3 +Mitral valve calcification 0.8196405648266889 1.770467866628724 0.0766492327874406 1.0 0.6528694391969805 4 P04062,O75844,O75431 3 +Cardiac valve calcification 0.8196405648266889 1.770467866628724 0.0766492327874406 1.0 0.6528694391969805 4 P04062,O75844,O75431 3 +Abnormality of the distal phalanges of the toes 0.8196405648266792 1.7704678666286813 0.0766492327874477 1.0 0.6528694391969805 4 Q7LGA3,O75844,O75431 3 +High frequency sensorineural hearing impairment 0.8196405648266789 1.7704678666286813 0.0766492327874477 1.0 0.6528694391969805 4 Q9NWM8,O75844,Q13510 3 +Hypertriglyceridemia 0.4943881255324979 1.7687570185075174 0.0769344323950573 1.0 0.6540851465290897 23 P22830,P38571,O75431,O95470,Q9UJS0,Q9BTV4,P50402,Q96MF7 8 +Abnormal enchondral ossification 0.4818166654478217 1.766547024583286 0.0773041196126895 1.0 0.6557798692058507 26 P08236,Q7RTS9,O75381,Q9UG56,P38435,Q96HY6,Q15738,O96028,P40855,O00116,O95202,Q96L58 12 +Mitochondrial respiratory chain defects 0.7197311968755227 1.7625653794130438 0.0779738204631168 1.0 0.6592593181329088 6 O75306,P00846,Q4J6C6 3 +Limb girdle muscular dystrophy 0.6450513251351152 1.7611366233357435 0.0782152816683856 1.0 0.6600852171683061 9 O14979,Q9BTV4,P50402,Q14118 4 +Respiratory failure 0.3888525933570345 1.7589751864810486 0.0785817232640124 1.0 0.6607768465620164 67 Q15165,Q5XKP0,O95169,Q9UHD9,Q9BT22,Q70HW3,Q13510,Q92804,P10253,Q8TD16,Q14118,Q9NX14,Q9NZJ7,P35637,O43819,P23786,Q9UQN3 17 +Abnormal metacarpal morphology 0.4510720284510447 1.758062942062412 0.0787368003042552 1.0 0.660842139299517 32 Q7RTS9,Q32P28,P16435,O43924,P16278,Q9NX62,Q96L58 7 +Beaking of vertebral bodies 0.6082012061324366 1.756040820500759 0.0790814387428757 1.0 0.6616913010346243 11 P08236,Q7RTS9,P04066,P16278,Q96L58 5 +Prominent superficial blood vessels 0.5698823626217293 1.754447840226736 0.0793538000349665 1.0 0.6616913010346243 14 Q9Y487,Q6NUK1,P20936,P02545,Q8NC56,O75844 6 +Zonular cataract 0.5957257361072158 1.7541621433159469 0.0794027279037905 1.0 0.6616913010346243 12 Q9H6K4,O76024 2 +Elevated hepatic transaminase 0.420128674274293 1.7525275344178668 0.0796831395433741 1.0 0.6616913010346243 97 Q5XKP0,Q16625,O75880,P23786,Q96MF7,P50416,O43772,Q13510,Q9UJS0,Q10713,Q15904,P20674,Q5HYI8,P22695,P35670,Q9BV10,O75845,P09622,P38571,O75431,Q9Y276,P10253 22 +Ankle clonus 0.5556900200661035 1.751537562295332 0.0798533569513255 1.0 0.6616913010346243 15 Q9NW15,Q15043,O94905,Q9NZJ7,O75298 5 +Hyperlipoproteinemia 0.6601928691742193 1.7505553741298148 0.0800225279057138 1.0 0.6616913010346243 8 Q9BTV4,P50402,Q9UJS0,P38571 4 +Increased ldl cholesterol concentration 0.6601928691742193 1.7505553741298148 0.0800225279057138 1.0 0.6616913010346243 8 Q9BTV4,P50402,Q9UJS0,P38571 4 +Enlarged ovaries 0.8147770255824243 1.7499213636371316 0.0801318837304085 1.0 0.6616913010346243 4 P21912 1 +Cirrhosis 0.4366031443179131 1.7497234071190568 0.0801660526641607 1.0 0.6616913010346243 43 Q14108,P22830,P38571,Q9Y276,P04062,Q9UJS0,Q10713,Q15904 8 +Peripheral demyelination 0.545546750077727 1.7490680690986582 0.0802792539046581 1.0 0.6616913010346243 16 Q9NR77,P20700,Q9NZJ7,P07196,P00846 5 +Ankylosis 0.7442961530846794 1.7476114729659409 0.080531327333273 1.0 0.6625794333101372 5 O75844,P16435 2 +Atrophic scars 0.6925847900166621 1.7455987494006815 0.0808806997247877 1.0 0.6642634927307701 7 Q8NCH0,Q96L58 2 +Abnormal thoracic spine morphology 0.4828934601290269 1.7409359801708129 0.0816948009779023 1.0 0.6683621963553736 25 P08236,Q7RTS9,O75477,P51648,O95831,Q9UHX1,P04062,O75844,O75845 9 +Esophageal varix 0.7426684229244447 1.740242187923449 0.0818165006211544 1.0 0.6683621963553736 5 P04062,P38571 2 +Paraplegia 0.4219357817956948 1.7377728643111594 0.0822508438731062 1.0 0.6707169169119549 50 O95831,Q9P0J0,Q96CU9,P04062,O60313,P00846,Q15041,Q7KZN9,Q96L58,O75298 10 +Hypoplasia of the odontoid process 0.6904968851411846 1.7354144237752205 0.0826674270982867 1.0 0.6728846625548738 7 Q7RTS9,P16278,O95831 3 +Abnormal protein glycosylation 0.5433081043002133 1.7342112012427782 0.0828806162273212 1.0 0.6728846625548738 16 Q9H0U3,Q9Y487,Q10471,Q9BT22,P51571,O75787,Q15904 7 +Frontotemporal dementia 0.6043112493168529 1.7337842270413992 0.0829563753008186 1.0 0.6728846625548738 11 Q9UHD9,P22626,O96008,P35637,Q9UQN3 5 +Abnormal greater sciatic notch morphology 0.6896992311913319 1.7315209667517264 0.0833588886341729 1.0 0.6731779246033252 7 P08236,Q9H6U8,Q7RTS9 3 +Young adult onset 0.591857367496915 1.731380290869411 0.0833839595024659 1.0 0.6731779246033252 12 Q14566,O15118,P02545,Q9NZJ7,P38435 5 +Abnormal brain lactate level by mrs 0.5918112658411474 1.7311084712058322 0.0834324197558902 1.0 0.6731779246033252 12 O43819,P21912,P00403 3 +Progressive visual loss 0.4770517619785586 1.7279470260281355 0.0839977222053756 1.0 0.6753652235461985 26 O14773,O75503,P50897,P00846 4 +Butterfly vertebrae 0.8093401459953289 1.72691521483372 0.0841828915116478 1.0 0.6754329848386009 4 Q9BV10 1 +Decreased muscle mass 0.5103646817966189 1.7247863533560932 0.0845659819737421 1.0 0.6754329848386009 19 Q8NCH0,Q9Y487,P04066,Q8TAA9 4 +Abnormal circulating long chain fatty acid concentration 0.8088369869184548 1.724784127749312 0.0845663832104119 1.0 0.6754329848386009 4 P23786,O75381 2 +Abnormal form of the vertebral bodies 0.4064522720871891 1.7246274439077829 0.0845946343459367 1.0 0.6754329848386009 86 Q6NUK1,Q9UM00,Q04656,O95202,Q96L58,Q5JRA6,P16435,Q96HY6,Q10713,Q7RTS9,P00813,O95831,Q8TAA9,Q9BV10,O75845,Q9Y4P3,P08236,Q32P28,Q5H8A4,Q9UHX1,P04066,P16278,P15586,P54802,Q9H0W5 25 +Parkinsonism 0.4449157418753887 1.7181489127827578 0.0857694570625331 1.0 0.6836242662744612 34 Q99720,O75569,Q709C8,P02792,Q9Y4W6,Q13501,Q15043,P04062,O75787,O96008,Q9NZJ7,P35637,Q9UQN3 13 +Spastic paraplegia 0.4277830865753336 1.7147611457125949 0.086389027841506 1.0 0.6863278035877558 46 O95831,Q9P0J0,Q96CU9,P04062,O60313,P00846,Q15041,Q7KZN9,O75298 9 +Intracellular accumulation of autofluorescent lipopigment storage material 0.9797947402180914 1.7144062454401634 0.0864541423155631 1.0 0.6863278035877558 2 O14773 1 +Infantile muscular hypotonia 0.382800351029628 1.712705676349161 0.0867667003301269 1.0 0.6863278035877558 65 Q9Y487,O95169,P17900,Q13510,Q9BVA1,Q15043,Q9GZY8,P10253,P16278,Q9NZJ7,O43819,P00846 12 +Corpus callosum atrophy 0.5628851500570529 1.710599291425406 0.0871551098870968 1.0 0.6863278035877558 14 O75503,P51572,P20700,O60313 4 +Slender long bone 0.5881069983668099 1.709243672867595 0.0874058222171585 1.0 0.6871235099297515 12 Q32P28,Q9Y487,P37268,Q96L58 4 +Rigidity 0.3992626458646396 1.7073802969506302 0.087751390112325 1.0 0.6886609094114259 58 P12235,O43681,P02792,Q96CU9,P04062,Q15392,P00846,O75787,P16278,Q9NZJ7,Q9H6K4,P04350,Q9UQN3,Q9BPX6 14 +Hand polydactyly 0.4504904581886399 1.70503550163849 0.0881878034330021 1.0 0.6897782626160669 31 P21964,Q5H8A4,P98175,O00459,Q9UM00,Q9UHX1,O43924,Q10713,O95202,Q15067,O75845 11 +Abnormality of the ischium 0.8036745952896891 1.702900317761207 0.0885867245666989 1.0 0.6898242463434332 4 Q9H6U8,Q9H0W5 2 +Recurrent aspiration pneumonia 0.7068325387506169 1.7018611942607706 0.0887813917722273 1.0 0.6898242463434332 6 P04062,Q13510 2 +Redundant neck skin 0.7063847359724374 1.699747697323635 0.0891783933635435 1.0 0.6902251355128732 6 Q9Y487 1 +Abnormal chorioretinal morphology 0.4732921630517318 1.697386541092888 0.0896236054032308 1.0 0.6902251355128732 26 O43505,Q5XKP0,O75381,Q9H9S5,P40855,Q14118,Q10713,Q9NX14,O60826 9 +Heparan sulfate excretion in urine 0.8023625953328345 1.6973332020059213 0.0896336834833706 1.0 0.6902251355128732 4 P15586,P54802 2 +Stroke like episode 0.7327087294382626 1.6950510214660237 0.0900657423554012 1.0 0.6902251355128732 5 P00403 1 +Punctate cataract 0.8018216715136068 1.6950373046013043 0.0900683442695031 1.0 0.6902251355128732 4 Q9H6K4,P08670 2 +Paraplegia paraparesis 0.3942600723441924 1.6928103474798355 0.0904915724564134 1.0 0.6902251355128732 77 Q5XKP0,Q13510,O95831,Q9P0J0,Q96CU9,O60313,O75298,Q7KZN9,P21912,P04062,O94905,Q15041,Q9H6K4,Q96L58,P00846,Q6DKK2 16 +Nonprogressive 0.7048246213869258 1.692381305003469 0.0905732945405239 1.0 0.6902251355128732 6 Q9NQZ5,Q10713 2 +Hypoplastic vertebral bodies 0.7044206689949304 1.690473177107323 0.0909374656197377 1.0 0.6902251355128732 6 Q8TAA9 1 +Elevated gamma glutamyltransferase level 0.8003345525181701 1.6887234794048795 0.0912724339326596 1.0 0.6902251355128732 4 Q5XKP0,P38571 2 +Inverted nipples 0.6808142358999343 1.6880527876273954 0.091401096229877 1.0 0.6902251355128732 7 P83436,P61978,Q9H6U8,Q9BV10,Q15067 5 +Shallow orbits 0.6137114748466143 1.685912932655027 0.0918125706065755 1.0 0.6902251355128732 10 O75431,P61978,Q9H6U8,P02545,Q8NC56,O75844 6 +Increased serum lactate 0.4262102826480656 1.6836592077218315 0.0922475491208907 1.0 0.6902251355128732 109 Q5XKP0,Q9P0J0,O75880,O14949,Q7KZN9,P13073,O95169,P14927,Q70HW3,Q86Y39,Q53H12,Q96CU9,P21912,P00846,P20674,P22695,O95831,Q9Y6M9,Q9UBX3,O43819,P00403,Q8IUX1,P09622,Q9NVI7,Q9Y276,Q9BWD1,Q5JRX3 27 +Thoracic scoliosis 0.5952498629538099 1.6817467969985942 0.0926179493470404 1.0 0.6902251355128732 11 O75477,O75844,O00459,Q9UHX1 4 +Abnormality of the tonsils 0.7024548383177887 1.6811826946411512 0.0927274337987578 1.0 0.6902251355128732 6 P00813 1 +Spastic gait 0.482413006770897 1.6757810758422238 0.093781082214825 1.0 0.6902251355128732 23 P20700,Q9NVI7,O75477,Q15043,O94905,Q15041,O75298 7 +Macular degeneration 0.5699603861671899 1.674529977762312 0.0940264878890262 1.0 0.6902251355128732 13 Q9NW15,P50897,P51648,Q13510 4 +Aplasia hypoplasia involving bones of the thorax 0.4401009503830734 1.674156601952325 0.0940998260713126 1.0 0.6902251355128732 34 Q7RTS9,O75431,Q9BV10,P98175,P16435,Q15738,Q96HY6,Q04656,Q9UHX1,P02545,Q8TAA9,Q8NC56,O75844,Q96L58,O60826 15 +Abnormality of the tongue 0.408809974221553 1.666475439820449 0.0956187560078372 1.0 0.6968027124317152 93 Q7LGA3,Q6NUK1,O75381,Q9H9S5,P98175,Q03252,Q13510,Q9BQT8,P61978,P21912,Q96S52,P40855,P02545,Q10713,P04350,P07196,Q16637,O60826,O95831,O94905,O43924,O75844,Q9Y4P3,P07686,Q05086,P20700,O75431,P10253,O75648,P04066,Q9NWS8,P16278,Q96A33 33 +Retinal detachment 0.5326987958297973 1.6635034750670117 0.0962116958214451 1.0 0.6978023921716141 16 O43505,Q9BV10,Q96MF7,Q8NCH0 4 +Peripheral axonal degeneration 0.3852476729826314 1.662339653651138 0.0964446912599426 1.0 0.6978023921716141 71 P41440,O15269,Q9UHD9,Q9BQT8,P02545,P07196,P00846,P12235,Q9Y4W6,O95831,O60313,Q9NZJ7,Q9BPX6,P00403,Q9NVI7,Q8IV08,P22626,Q9HC21,O95140,O76024,Q15067,Q6DKK2 22 +Genu valgum 0.4394224790317111 1.6601583233722272 0.0968826063725158 1.0 0.6978023921716141 33 Q9NR77,P08236,Q7LGA3,Q7RTS9,O75431,Q04656,P16278,Q9NX62,Q96L58 9 +Achilles tendon contracture 0.5674392835053499 1.659117237687525 0.0970921704015519 1.0 0.6978023921716141 13 Q9Y3E5,O60313,Q8TD16,P02545,Q9BTV4,P50402 6 +Multiple lipomas 0.6745808737827337 1.657449949984236 0.0974285398371201 1.0 0.6988975412378419 7 Q9Y2U8,Q8TAA9 2 +Respiratory distress 0.4074626200441666 1.6566822679272717 0.097583729857593 1.0 0.6989187266399524 53 O95169,O75306,Q13510,O43819,Q16134,P10253,O95831,P51571,Q9UHX1,P04062,Q9NX14,Q9NZJ7,P04350,P23786,Q96L58,P00846 16 +Subcutaneous hemorrhage 0.4335211168795284 1.6518513220067854 0.0985648634124152 1.0 0.7026572793888172 38 Q14108,Q9NWM8,P38435,Q16625,P04062,P35670,Q8NCH0,P21964,Q96L58 9 +Abnormal endocrine physiology 0.722520941424438 1.6486515271367577 0.0992190459905879 1.0 0.7027172360634562 5 Q13423 1 +Supranuclear gaze palsy 0.4851647570078783 1.644384942756148 0.1000967133598891 1.0 0.7027172360634562 21 Q99720,P02792,Q969N2,Q13501,O15118,P61916,P04062,Q9NZJ7,P35637,Q96RL7 10 +Decreased circulating total igm 0.6229419281709903 1.6430712701225971 0.100368188279085 1.0 0.7027172360634562 9 P00813 1 +Abnormality of the knee 0.3964852656336717 1.6429557756506792 0.1003920836462275 1.0 0.7027172360634562 83 Q7LGA3,Q86XL3,Q04656,Q15041,P23786,Q96L58,Q13510,O75477,Q96HY6,P21912,Q9NX62,Q9NR77,Q7RTS9,O00459,O95831,O94905,P21964,P37268,P08236,O75431,Q8TD16,P16278 22 +Abnormality of the pubic bone 0.6058452577265837 1.6422128176845976 0.1005459072583985 1.0 0.7027172360634562 10 Q7RTS9,Q5H8A4,O96028,Q04656,O95202,Q9H0W5 6 +Hydrocele testis 0.721078981499531 1.6420705011476604 0.1005753942069693 1.0 0.7027172360634562 5 Q9UBX3 1 +Abnormality of the metacarpal bones 0.4293007938986056 1.6356837049948318 0.1019058015807643 1.0 0.7072656127824687 40 P08236,Q7RTS9,Q32P28,P16435,O43924,P16278,Q9NX62,O95202,Q96L58 9 +Neoplasm of fatty tissue 0.5872021380002073 1.6353090309783562 0.1019842813465463 1.0 0.7072656127824687 11 P21912,Q9Y2U8,Q8TAA9 3 +Cns demyelination 0.5368663669054903 1.629168458077866 0.1032773622219711 1.0 0.7140758583751047 15 Q5H8A4,P51648,P40855,Q9NZJ7,Q15067 5 +Abnormal lung development 0.4171190460423056 1.6257084943720344 0.1040116821853709 1.0 0.7157245586738462 47 Q96DF8,Q15645,Q6NUK1,Q14739,P21964,Q16134,Q5H8A4,P98175,Q9H6U8,Q15738,O96028,Q9UHX1,O96000,P02545,Q8TAA9,O95202,O75844,Q96L58 18 +Abnormal circulating citrulline concentration 0.7852610097671405 1.6245741801206928 0.1042533224513042 1.0 0.7157245586738462 4 P00846 1 +Urinary urgency 0.6357789537110944 1.6244204388709058 0.104286107870761 1.0 0.7157245586738462 8 P04062,O75298 2 +Abnormal liver physiology 0.690292482083361 1.6235370609054491 0.1044746475277218 1.0 0.7157245586738462 6 Q9UJS0,Q13510 2 +Abnormality of the alveolar ridges 0.6898149201447602 1.621267831264854 0.1049602109132985 1.0 0.7157245586738462 6 Q15392,O43924 2 +Talipes calcaneovalgus 0.7164508108241693 1.620925376745158 0.1050336436922187 1.0 0.7157245586738462 5 P07196 1 +Emg neuropathic changes 0.4636774248025132 1.6188190524430448 0.1054862015521431 1.0 0.7157245586738462 26 O14773,Q8TB36,Q9NR77,Q969X5,Q13510,O43681,Q04656,O60313,P22626,O95140,Q9NZJ7,O43819,Q16637,Q96RL7 14 +Joint stiffness 0.4015824785334479 1.618557618651759 0.1055424801180993 1.0 0.7157245586738462 54 P08236,O75431,P51648,P16435,Q9Y2U8,O76024,Q8TAA9,Q9BTV4,P54802,P15586,P16278,O75844,P50402,Q9Y4P3 14 +Centrocecal scotoma 0.7828196983356671 1.614159547008756 0.1064928239750586 1.0 0.717146161986921 4 P00846,O60313 2 +Left ventricular systolic dysfunction 0.6654640226363762 1.6125350372707032 0.1068455619253003 1.0 0.717146161986921 7 O75844,P02545 2 +Limited elbow movement 0.4279539386927296 1.6104775454447828 0.1072936436447271 1.0 0.7186181496883266 39 Q7LGA3,Q7RTS9,P16435,Q04656,P37268,O94905,Q96L58,Q9H6K4,P23786,P50402 10 +Abnormal lactate dehydrogenase level 0.4945800390583015 1.6100913080258612 0.1073779243489854 1.0 0.7186181496883266 19 O43505,P38571,P10253,Q9UJS0,Q14118,P23786,Q5JRX3 7 +Aplasia hypoplasia of the pubic bone 0.6870397810655448 1.6080728115233562 0.1078192330298328 1.0 0.7189609198433959 6 Q5H8A4,O95202,Q9H0W5 3 +Abnormal femoral neck morphology 0.4299185158775776 1.6071688532253177 0.1080173325556008 1.0 0.7189609198433959 37 Q9Y487,Q7RTS9,O75431,O95831,Q04656,P04066,P16278,O75844,Q96L58,Q96A33 10 +Impaired temperature sensation 0.6865435463328419 1.6057118503842405 0.1083372363286523 1.0 0.7192399856194168 6 Q9NR77,O15269,O95140,P07686 4 +Abnormal femoral neck head morphology 0.4185644093563722 1.604425174347659 0.1086203656466913 1.0 0.7192399856194168 45 Q9Y487,Q7LGA3,Q7RTS9,O75431,Q04656,O95831,P04066,P16278,O75844,Q96L58,Q96A33 11 +Motor deterioration 0.7125339940997071 1.6030040465060882 0.1089337607150144 1.0 0.7192399856194168 5 O75503 1 +Pedal edema 0.6315137338828457 1.6022327400811711 0.1091041526974512 1.0 0.7192399856194168 8 Q14108 1 +Epiphyseal stippling 0.5814802877939963 1.6021683179605184 0.1091183939440265 1.0 0.7192399856194168 11 P08236,O75381,Q15738,P40855,O00116,P38435 6 +Upper limb postural tremor 0.7798459563542963 1.601464583003295 0.1092740583604237 1.0 0.7192399856194168 4 Q9NR77,P04350,P20700 3 +Abnormality of alkaline phosphatase level 0.4823950654031345 1.600263441725284 0.1095401533628688 1.0 0.7192399856194168 20 Q14739,P38571,Q969N2,Q13501,P22626,Q92643,Q96S52,Q9UJS0,Q96A33,O75845 10 +Occipital encephalocele 0.7106189158927769 1.5942330534463698 0.1108838458550138 1.0 0.7192399856194168 5 Q10713 1 +Cogwheel rigidity 0.6617549082674019 1.5942100496285443 0.1108889963749304 1.0 0.7192399856194168 7 P00846,O75787 2 +Anhidrosis 0.709935396673775 1.5911012107463762 0.1115868001045896 1.0 0.7215422525072832 5 P04066,Q9Y276 2 +Subcutaneous nodule 0.4917310661084509 1.5892569569832218 0.1120023921482673 1.0 0.7220780922075224 19 P06280,Q9NZ08,Q13510,P21912,Q9Y2U8 5 +Paralysis 0.3988242921671808 1.5883966419260185 0.1121966763535617 1.0 0.7220780922075224 54 Q9NR77,P17900,P20700,Q9UHD9,Q92804,P10253,P04062,P21912,Q9HC21,P35637,Q15165,Q9BTV4,P50402,Q9UQN3 14 +Hypercholesterolemia 0.5790849421177895 1.588264554367702 0.1122265290935409 1.0 0.7220780922075224 11 Q15904,O75431,Q9UJS0,P38571 4 +Unsteady gait 0.4074609005979645 1.5864407282693282 0.1126393675951893 1.0 0.7222448835607741 50 O75503,Q9NR77,Q9H6K4,O95831,Q14118,Q10713,Q15907,P07196,Q5JRX3 9 +Morphological abnormality of the pyramidal tract 0.4773399887320711 1.5846969584549058 0.1130352032726673 1.0 0.7237721314153638 21 O75569,O95831,Q9H9P8,O75298,P35637,P00846,Q9Y4P3 7 +Coxa valga 0.4909957939935582 1.5838735061018283 0.1132225075657933 1.0 0.7239041943057202 19 P04066,P16278,O75844,Q96L58,Q96A33 5 +Clonus 0.4316973612740458 1.5830406341108547 0.1134122031317221 1.0 0.7239041943057202 32 Q99720,Q9NW15,P20700,O75027,O75477,Q9BQT8,Q15043,O94905,Q3ZCQ8,Q9NZJ7,P35637,O75298 12 +Abnormal pharynx morphology 0.4273046787333173 1.5825289659902328 0.1135288651492307 1.0 0.7239041943057202 37 Q7RTS9,Q13510,P00813,P16278,P15586,P54802,Q9BV10 7 +Tetraplegia tetraparesis 0.4108760888600586 1.5808780530712785 0.1139059233370838 1.0 0.7247455681637277 48 Q7RTS9,P17900,P20700,O43681,Q13423,O95831,O94905,P21912,P51572,Q9UBX3,Q9NZJ7,P35637,P00846 13 +Purpura 0.5107276725808629 1.5798872971007174 0.1141326788195371 1.0 0.7247455681637277 17 Q8NCH0,P21964,P38435,Q16625 4 +Posterior embryotoxon 0.5104680325228269 1.5780898122689937 0.1145449783378755 1.0 0.725346200757499 17 Q7LGA3,O75381,P40855,Q9NX14,P21964 5 +Disproportionate short trunk short stature 0.70668720902615 1.576208639625693 0.1149777280955248 1.0 0.7266958056550272 5 Q7RTS9,P16278 2 +Abnormal hdl cholesterol concentration 0.7737483953786726 1.5754040234315636 0.1151632162970461 1.0 0.7266958056550272 4 P02545,Q9UJS0,P38571 3 +Bruising susceptibility 0.4407594746477154 1.5751017251846062 0.1152329659152384 1.0 0.7266958056550272 30 Q14108,Q9NWM8,P04062,P35670,Q8NCH0,P38435,Q96L58 7 +Hyperkeratosis 0.3874674657165536 1.5732333270861376 0.1156648010457488 1.0 0.7267979053666354 58 P06280,P16615,P98194,O75431,Q9NWM8,P51648,O95721,P04062,P21912,P04066,Q9Y2U8,P42167,O15269,O75844 14 +Aplasia hypoplasia of the capital femoral epiphysis 0.7054194717628548 1.5703919622027998 0.116323951262836 1.0 0.7267979053666354 5 Q7LGA3 1 +Aspiration pneumonia 0.460863408310849 1.5635753676636088 0.1179173233417101 1.0 0.731190226755173 25 Q6NUK1,Q13510,O95721,P04062,P16278 5 +Platyspondyly 0.4260414013705111 1.5611104447709203 0.1184976941007076 1.0 0.731190226755173 36 P08236,Q6NUK1,Q7RTS9,Q32P28,P00813,Q04656,O95831,P04066,P16278,Q96L58 10 +Lipoma 0.6545540848726027 1.5585509229240122 0.119102706467544 1.0 0.731190226755173 7 Q8TAA9 1 +Abnormality of the gallbladder 0.4246890115836511 1.5578165783381843 0.1192767349121335 1.0 0.731190226755173 37 P22830,P21964,Q5H8A4,Q9Y4P3,P04062,P04066,P40855,Q9NZJ7,O95202,Q96A33,O75845 11 +Glomerulopathy 0.5905726354683591 1.5568610381745978 0.1195034815851991 1.0 0.731190226755173 10 P06280,Q14108,Q9NZ08,Q03252 4 +Severe muscular hypotonia 0.4278791223764019 1.5545348859556296 0.1200568819166436 1.0 0.731190226755173 33 Q01105,O43505,O75381,Q9H9S5,Q9NWM8,O75746,Q5H8A4,Q9GZY8,O95831,P40855,P02545,Q8TD16,Q9NWS8 13 +Renal tubular dysfunction 0.4189339537761714 1.5481937796303082 0.1215756485957042 1.0 0.731190226755173 41 Q8IUX1,O95169,Q86Y39,Q9Y276,Q96CU9,Q9Y6M9,P40855,O96000,P35670,Q9NX14,Q9NPL8,O43819,P00403,P50416 14 +Abnormal basal ganglia mri signal intensity 0.432552578726369 1.5452111659344732 0.1222951943873469 1.0 0.731190226755173 31 Q9GZY8,Q9P0J0,Q96CU9,P16278,Q7KZN9,P00846 6 +Abnormal iliac wing morphology 0.5364500900907859 1.5432524949318032 0.1227695248977336 1.0 0.731190226755173 14 Q7RTS9,O95831,P16278,Q8TAA9,Q96L58 5 +Limited extraocular movements 0.6201836081616221 1.5430852912319788 0.122810083032095 1.0 0.731190226755173 8 O43819,O95169,Q9BVA1 3 +Infantile axial hypotonia 0.6041544527455779 1.541721877790727 0.1231411931699899 1.0 0.731190226755173 9 Q9NZJ7,P17900,Q15043 3 +Prenatal maternal abnormality 0.5599623459848001 1.5416081971832465 0.1231688323942246 1.0 0.731190226755173 12 O43772,Q8TAA9,P50416 3 +Athetosis 0.5142633140113305 1.5394988674938774 0.1236825541574362 1.0 0.731190226755173 16 Q96CU9,Q9UHD9,O14949 3 +Increased circulating lactate dehydrogenase concentration 0.5357567309854231 1.5388285832692163 0.1238461498385175 1.0 0.731190226755173 14 P38571,P10253,Q9UJS0,P23786,Q5JRX3 5 +Angiokeratoma 0.9233237086942552 1.536469303994292 0.1244233206671951 1.0 0.731190226755173 3 P06280,P16278 2 +Ascending tubular aorta aneurysm 0.7644415917843194 1.5355537099763952 0.1246478746361583 1.0 0.731190226755173 4 O75844,Q96L58,P02545 3 +Cerebral white matter atrophy 0.4837915756127327 1.5309883284374728 0.1257722772684508 1.0 0.731190226755173 19 O75503,P51572,P20700,O60313 4 +Color vision defect 0.5218836837056571 1.530750616719914 0.1258310387549157 1.0 0.731190226755173 15 Q9H061,Q709C8,Q9Y4W6,O60313,Q6P4Q7,O95140,Q9H6K4 7 +Spondyloepimetaphyseal dysplasia 0.617817077635514 1.5306939890236555 0.125845040072831 1.0 0.731190226755173 8 Q7RTS9,Q96L58,O95831 3 +Thickened ribs 0.9217196021815804 1.5302034040152814 0.1259663890651357 1.0 0.731190226755173 3 P16278,P54802 2 +Aplasia hypoplasia of the lungs 0.4233656818977367 1.5274813475164453 0.1266413619332227 1.0 0.731190226755173 35 Q6NUK1,Q14739,Q16134,Q5H8A4,P98175,Q9H6U8,Q15738,O96028,O96000,P02545,Q8TAA9,O95202,O75844,Q96L58 14 +Abnormality of the musculature of the lower limbs 0.4443196726215787 1.5272315488776174 0.126703443861684 1.0 0.731190226755173 28 Q9NR77,Q9NW15,Q9H9S5,O14979,P02545,Q9BTV4,Q14118,P07196,Q9NRG9,P50402,P00846 11 +Tremor by anatomical site 0.439766597861323 1.5259152779451968 0.1270309653010113 1.0 0.731190226755173 29 Q9NR77,Q99720,Q05086,P20700,Q9Y4W6,O94905,Q9HA77,P22307,O95140,Q15120,P35637,P04350,P07196,Q16637,Q92734,Q96RL7 16 +Hyperreflexia in upper limbs 0.6011461623910752 1.5254110127449312 0.1271566136300765 1.0 0.731190226755173 9 O94905,P21912,O75298 3 +Increased urine alpha ketoglutarate concentration 0.6952999947300366 1.523878733310453 0.1275390068744601 1.0 0.731190226755173 5 P21912 1 +Slow decrease in visual acuity 0.6008551752522232 1.5238321213143686 0.127550653295204 1.0 0.731190226755173 9 Q969G3,O95140,O75306,P00846 4 +Absent epiphyses 0.6693198266927387 1.5234927349068037 0.1276354769421868 1.0 0.731190226755173 6 Q7LGA3 1 +Hepatosplenomegaly 0.4208931053456252 1.5218563580924815 0.1280450763895169 1.0 0.731190226755173 37 Q5HYI8,Q13510,P38571,Q9H6U8,P04062,Q9UJS0,P16278,P10619,O75845 9 +Weakness of muscles of respiration 0.4195951266512519 1.5194810310729323 0.1286414591735434 1.0 0.731190226755173 38 Q7RTS9,Q13510,P10253,O95831,P22626,O95140,Q8TD16,P02545,Q9BTV4,P50402,Q15067 11 +Chordee 0.6466559777337628 1.5193158701167249 0.1286830069212741 1.0 0.731190226755173 7 P16435 1 +Abnormality of the vasculature of the eye 0.3735054284557353 1.5192317563143998 0.128704170524124 1.0 0.731190226755173 71 P06280,P17900,Q13510,P38435,P04066,P21912,P16278,Q9NZJ7,P06865,P21964,P10619,P00846 12 +Thin ribs 0.5320365028302089 1.5150631043366911 0.1297564241179565 1.0 0.7342912939194096 14 O75431,Q32P28,O95831,O75844,Q9H0W5 5 +Central hypoventilation 0.6457093535989655 1.5146049632077367 0.1298724745507646 1.0 0.7342912939194096 7 O43819,O95169 2 +Abnormality of subcutaneous fat tissue 0.5314309362810802 1.511190063202955 0.1307400333774615 1.0 0.7359253596931649 14 Q9Y487,Q6NUK1,O75431,Q8NC56,O75844 5 +Delayed epiphyseal ossification 0.7587038556416668 1.510944162705658 0.1308026777411506 1.0 0.7359253596931649 4 Q9UG56,Q96L58 2 +Death in infancy 0.3765913691142253 1.5094124590676896 0.1311934111040309 1.0 0.7365677927924686 60 P20674,Q6NUK1,Q15067,O75381,Q9BT22,O75718,P38571,Q9BUB7,P04062,Q9HC21,P40855,P02545,Q9NWS8,Q9NZJ7,P16278,O43819,O60826,Q15904 18 +Acute hepatic failure 0.5311259416596644 1.5092389184323882 0.1312377378575995 1.0 0.7365677927924686 14 P38571,Q16836,Q6NUQ1,O75648,P35670 5 +Titubation 0.5970430495352346 1.5031288129796592 0.1328058300778458 1.0 0.7401953319213413 9 P35637,Q99720,Q5JRX3 3 +Chorioretinal dysplasia 0.6433742365899235 1.502976631756546 0.1328450700911387 1.0 0.7401953319213413 7 O43505,Q14118,Q9NX14 3 +Basal ganglia calcification 0.664985218914929 1.502720874228972 0.1329110375320863 1.0 0.7401953319213413 6 P00403 1 +Urinary bladder sphincter dysfunction 0.6124558433893939 1.502576293853525 0.1329483403118836 1.0 0.7401953319213413 8 Q9NR77,O75298 2 +Hyperconvex nail 0.6432317796461249 1.502266884628247 0.1330281973562552 1.0 0.7401953319213413 7 O95202,P42892 2 +Echolalia 0.5643076884313604 1.50211030891021 0.1330686229491868 1.0 0.7401953319213413 11 Q9UHX1,O75787,Q9NX14,Q9UJS0,Q9UQN3 5 +Metatarsus adductus 0.5300082175171453 1.5020857477579403 0.1330749651473559 1.0 0.7401953319213413 14 P08236,Q03252,Q15392,O95202,Q96L58 5 +Abnormal meningeal morphology 0.4567883795839472 1.5011083793749609 0.1333275318702438 1.0 0.7401953319213413 24 Q15904,Q9UHX1,Q8TAA9,Q10713,P21964,O75845 6 +Abnormal atrioventricular conduction 0.5298509666621902 1.5010790344272622 0.1333351207795576 1.0 0.7401953319213413 14 P06280,O43772,P21912,Q9BTV4,P50402 5 +Abnormality of lysosomal metabolism 0.9137061839535264 1.4988875401031547 0.1339028093042804 1.0 0.7409194199321842 3 Q13510 1 +Progressive sensorineural hearing impairment 0.5630797272848689 1.4949224796127696 0.1349346747400954 1.0 0.7409194199321842 11 P00403,O60313 2 +Laryngeal dystonia 0.7548138639281099 1.494242952734741 0.1351121296790705 1.0 0.7409194199321842 4 P02792,P04350,O75569 3 +Convex nasal ridge 0.4622178579040264 1.4917113835193037 0.1357748235801867 1.0 0.7409194199321842 22 Q6NUK1,Q9H6U8,O96028,Q04656,Q8NC56,O95202,O75844 7 +Absent brainstem auditory responses 0.911775964164856 1.4913411996181842 0.135871937354997 1.0 0.7409194199321842 3 P07196 1 +Slurred speech 0.578900638611778 1.4912017750686417 0.1359085277917482 1.0 0.7409194199321842 10 Q9Y487,Q9NW15,P16278 3 +Mucosal telangiectasiae 0.5948438034892757 1.4911692260936174 0.1359170710069794 1.0 0.7409194199321842 9 P06280,P10619 2 +Hypermetric saccades 0.9117069005803912 1.4910711696300845 0.1359428106516333 1.0 0.7409194199321842 3 O14773 1 +Abnormal circulating proteinogenic amino acid derivative concentration 0.4588824782684994 1.4906737300876878 0.1360471763594661 1.0 0.7409194199321842 23 P20674,Q5XKP0,P22695,Q9P0J0,O96000,O75880,P00846,Q8IUX1 8 +Poor wound healing 0.6880940220720007 1.4906716699935751 0.1360477174913594 1.0 0.7409194199321842 5 P04062 1 +Abnormality of circulating adrenocorticotropin level 0.6405111162931293 1.4887044893714405 0.1365652023142363 1.0 0.7411734820922918 7 Q13423 1 +Vascular tortuosity 0.7534767171768016 1.4884990833891332 0.1366193237013069 1.0 0.7411734820922918 4 P00846,Q04656 2 +Intellectual disability progressive 0.5277682926455987 1.487737867050491 0.136820037092908 1.0 0.7411734820922918 14 Q05086,O95831,O95721,Q9NX14,Q15067 5 +Flaring of rib cage 0.9095283926852726 1.482552776246871 0.1381932717754601 1.0 0.7436357199967486 3 Q7RTS9,P16278 2 +Abnormal ureter morphology 0.4389819262104833 1.4815595454203496 0.1384575299489931 1.0 0.7436357199967486 28 Q7LGA3,P23786,O76024,Q8TAA9,O75844 5 +Vacuolated lymphocytes 0.9230275817832004 1.4790057000595775 0.139138791387557 1.0 0.7448736785016736 2 P16278 1 +Hip pain 0.6855513761058563 1.478938426093431 0.1391567721565021 1.0 0.7448736785016736 5 P22626,O75844 2 +Babinski sign 0.391933649467887 1.4757676277206817 0.1400062839700273 1.0 0.745068270429258 92 O14773,Q99720,P41440,O75027,P35637,O75298,P02792,O75477,P21912,Q9H6K4,P07196,P00846,Q9UQN3,Q9NR77,Q13217,Q9Y4W6,Q15043,O95831,O60313,O94905,Q9NZJ7,P20700,O43681,O95140,O75787,Q15067,Q6DKK2 27 +Abnormal delivery 0.4655386947883021 1.472508282855466 0.1408836719627493 1.0 0.745068270429258 20 Q9Y487,O75718,O60313,P02545,Q8NC56,O75844 6 +Asymmetric septal hypertrophy 0.9214239897370168 1.472349764208672 0.1409264513878771 1.0 0.745068270429258 2 P54802 1 +Abnormal adipose tissue morphology 0.3810773810669515 1.4709713440528729 0.1412988666970589 1.0 0.745068270429258 57 Q9Y487,Q6NUK1,O75431,Q9BV10,O75844,Q9H6U8,Q03252,P04066,P21912,O95140,Q9Y2U8,P42167,Q8TAA9,Q8NC56,Q9BTV4,P50402 16 +Osteolysis involving bones of the feet 0.7493513701579074 1.4707689259962762 0.1413536187200792 1.0 0.745068270429258 4 O75844,O75431 2 +Foot acroosteolysis 0.7493513701579074 1.4707689259962762 0.1413536187200792 1.0 0.745068270429258 4 O75844,O75431 2 +Anterior rib cupping 0.6836051242642973 1.4699518399148563 0.1415747979358368 1.0 0.7453783226186087 5 P00813 1 +Hypoglycemic seizures 0.6363693369952647 1.4680307589959476 0.1420958679368527 1.0 0.7469097845851225 7 Q16836,Q13423 2 +Brittle hair 0.5121621152717957 1.4664362562490014 0.1425294750677304 1.0 0.7469097845851225 15 Q9Y276,Q9Y487,O75844,Q9NVI7 4 +Positional foot deformity 0.4001046362795121 1.4656599111443684 0.1427409607559386 1.0 0.7469097845851225 101 Q9Y487,Q9NWM8,Q9UM00,Q9Y3E5,Q15907,O95202,Q96L58,P16435,Q8NCH0,P07196,Q9NR77,Q7RTS9,Q8TAA9,Q9BV10,P21964,O75845,P08236,Q9NVI7,Q5H8A4,Q9H6U8,Q9UHX1,Q9HC21,Q8TD16,Q96A33 24 +Abnormality of the pharynx 0.4015361183338561 1.4655831761553788 0.1427618773575092 1.0 0.7469097845851225 47 Q7RTS9,Q13510,P00813,P16278,P15586,P54802,Q9BV10,P21964 8 +Ulnar claw 0.7480744544287341 1.4652781808537068 0.1428450369437224 1.0 0.7469097845851225 4 Q9NR77,Q8TB36,P07196 3 +Abnormal muscle fiber protein expression 0.604986760277403 1.4633005802498749 0.1433851490441504 1.0 0.7469097845851225 8 P02545,P50402,Q14118,Q9BTV4 4 +Basal ganglia gliosis 0.5736912818541323 1.461783375426083 0.1438005811624192 1.0 0.7469097845851225 10 O43819,P00846 2 +Ectrodactyly 0.4936776411592912 1.4612466296325577 0.143947770564869 1.0 0.7469097845851225 17 Q99720,P07196,O95202,Q5H8A4 4 +Knee flexion contracture 0.4443809423711761 1.4594111812556412 0.1444519703698823 1.0 0.7469097845851225 26 Q7LGA3,O75477,Q86XL3,P37268,O94905,P21912,Q8TD16,P23786 8 +Primary adrenal insufficiency 0.522966324434455 1.4569217357746955 0.1451379853703454 1.0 0.7469097845851225 14 O75381,Q13423,Q99496,P16435,P40855,P51659,Q9NRG9,Q969G3 8 +Short nail 0.6799414246804624 1.4530226712137229 0.1462174594579495 1.0 0.7469097845851225 5 Q9Y487,O75844,Q96L58 3 +Episodic tachypnea 0.6028006107174757 1.4517828579191028 0.1465619917773921 1.0 0.7469097845851225 8 O43924,Q10713 2 +Diffuse cerebral atrophy 0.5099156107283905 1.451525577423972 0.1466335653262991 1.0 0.7469097845851225 15 P16278,Q10713 2 +Abnormal circulating glutamine family amino acid concentration 0.6531015651221941 1.445619733925261 0.1482838885443951 1.0 0.7469097845851225 6 P20674,O96000 2 +Paraparesis 0.4302846968306534 1.4432801701603089 0.1489415635053026 1.0 0.7469097845851225 29 Q5XKP0,Q13510,P04062,P21912,O75787,P35637,Q9H6K4,Q6DKK2 8 +Progressive spastic quadriplegia 0.631344398689021 1.4429058778690165 0.1490469871490991 1.0 0.7469097845851225 7 P17900,Q9NZJ7 2 +Leg muscle stiffness 0.7426639916018046 1.4419995513937354 0.149302500166351 1.0 0.7469097845851225 4 P00846 1 +Venous insufficiency 0.6522380859000034 1.4414623216641074 0.149454114560755 1.0 0.7469097845851225 6 P04062,P21964,Q04656 3 +Non midline cleft lip 0.65151223246838 1.4379666946496994 0.1504435042751049 1.0 0.7469097845851225 6 Q02127 1 +Aplasia hypoplasia involving the pelvis 0.4992809338910399 1.4377179797569983 0.1505140894819652 1.0 0.7469097845851225 16 O75431,Q5H8A4,Q96HY6,O95831,O96028,O95202,Q96L58,Q9H0W5 8 +Erlenmeyer flask deformity of the femurs 0.9127645926876198 1.4364140112585355 0.1508845685585442 1.0 0.7469097845851225 2 Q9NZJ7 1 +Ureteral duplication 0.5997619184510676 1.4357574702034257 0.1510713656148623 1.0 0.7469097845851225 8 O75844,Q8TAA9 2 +Cardiomegaly 0.4133609448421443 1.433591862404825 0.1516887670857836 1.0 0.7469097845851225 35 P20674,P13473,Q9Y4P3,P10253,P04062,P04066,Q96S52,P54802,P23786,P50416 10 +Low alkaline phosphatase 0.7406931964056308 1.4335149506828757 0.1517107294277719 1.0 0.7469097845851225 4 Q96S52,Q92643,P38571 3 +Muscle fiber atrophy 0.4574859921116082 1.4318151800736825 0.1521967217201432 1.0 0.7469097845851225 21 Q99720,P22626,Q9BTV4,P35637,P23786,P50402 6 +Areflexia 0.3870077295468395 1.4282515081747584 0.1532194797849935 1.0 0.7485684671285684 91 Q8TB36,P41440,Q9H9S5,Q9BT22,Q15041,O15269,Q13510,Q969X5,Q9BQT8,P61978,O75477,Q13501,Q9HA77,P02545,Q9H6K4,P07196,Q9NR77,Q13217,P12235,P05023,O95831,O60313,O95721,O43819,O43505,P10253,O95140,Q9NWS8,Q8TD16,Q14118,O75787,Q15067 32 +Metaphyseal widening 0.4474099988447302 1.4254574696441764 0.1540250057592684 1.0 0.7506675174530802 24 Q7RTS9,Q9H6U8,O95831,Q04656,P16278,Q96L58,Q96MF7 7 +Hemianopia 0.5974551043148052 1.423579621912342 0.1545681982931586 1.0 0.7510775267527712 8 P00403 1 +Decreased circulating igg level 0.5668718097876366 1.423171184156742 0.1546865368231333 1.0 0.7510775267527712 10 P00813 1 +Tritanomaly 0.8940464325221966 1.4219844553390577 0.155030763639179 1.0 0.7510775267527712 3 Q9H6K4 1 +Anomalous trichromacy 0.8940464325221966 1.4219844553390577 0.155030763639179 1.0 0.7510775267527712 3 Q9H6K4 1 +Abnormal exteroceptive sensation 0.3973216327034497 1.4218986667007405 0.1550556703262222 1.0 0.7510775267527712 47 P06280,Q9NR77,P07196,O95831,P54802,Q9NZJ7,O15269,Q8NCH0,Q9H6K4 9 +Atlantoaxial dislocation 0.9092366901860276 1.421777959381268 0.1550907199655036 1.0 0.7510775267527712 2 Q8NCH0 1 +Macrovesicular hepatic steatosis 0.6270061282710632 1.4211777514751658 0.1552650909494719 1.0 0.7511296444141472 7 P23786,Q5XKP0,O75431 3 +Prominent sternum 0.8934873275585465 1.4197964100490834 0.1556669604092131 1.0 0.7521816586439475 3 Q7RTS9,P16278 2 +Abnormal heart valve morphology 0.3706886511520778 1.4188824942881546 0.1559332767476247 1.0 0.7521816586439475 76 Q6NUK1,P04062,O95202,Q96L58,P06280,P55795,O96028,Q8NCH0,Q9NX14,P21964,O75844,P37268,Q9Y4P3,P08236,O75431,Q5H8A4,Q9H6U8,Q9BUB7,Q9UHX1,P16278 20 +Hypoventilation 0.5285700213728458 1.4187426212254306 0.155974066440653 1.0 0.7521816586439475 13 Q9H9S5,O43819,O95169,O75306 4 +Limb muscle weakness 0.3799356933669446 1.416885306804624 0.1565164630241982 1.0 0.7530758614322801 85 Q99720,Q8TB36,P20936,O15269,P50402,O75298,Q13510,Q969X5,Q9BQT8,Q13501,Q86U42,P02545,P07196,Q16637,P00846,Q9NR77,P12235,Q7RTS9,Q14739,Q9Y4W6,P05023,O94905,P35670,O43819,Q9BTV4,O95140,Q15067 27 +Protuberant abdomen 0.6717787965044528 1.4152492656276057 0.1569954244991465 1.0 0.7537827254187676 5 Q7RTS9,P38571 2 +Incomplete penetrance 0.4268715138524833 1.4133942110069255 0.1575398467927755 1.0 0.7549743597344808 29 O60313,O14979,P21912,O95140,Q92733,P00846 6 +Poor suck 0.4263084079861751 1.4084567208853622 0.1589958737264447 1.0 0.759573419644233 29 O43464,Q05086,O95169,O75306,Q15233,Q8TAQ2,P22695,Q04656,O75648,O75962,O43819 11 +Lower limb muscle weakness 0.4005080312431568 1.4064841133815194 0.1595804187875713 1.0 0.7615734954820582 44 P20936,P04792,P53007,O75298,Q13510,Q969X5,Q8IY17,P02545,P07196,Q969G3,Q8N0X7,P00846,Q9NR77,Q9Y6X9,Q9Y4W6,Q99496,O94905,Q15120,O43819,Q92734,P19367,O95140 22 +Sclerocornea 0.5635277730676238 1.4041967133229738 0.1602602803053809 1.0 0.7640238285379065 10 Q6NUK1,Q5H8A4,O96028,Q9NX14,O95202 5 +Abnormal metatarsal morphology 0.4298359961276542 1.4028941035593143 0.1606484194520436 1.0 0.7642869364811735 28 O43505,P08236,Q7RTS9,P16435,Q03252,O96028,Q15392,Q14118,O95202,Q96L58 10 +Meningocele 0.5631234257571411 1.4019006470664157 0.1609449172398107 1.0 0.7643470947023697 10 Q10713,P21964,Q8TAA9 3 +Abnormal choroid morphology 0.4336755960521574 1.4017361859304338 0.1609940406397716 1.0 0.7643470947023697 27 O43505,Q5XKP0,O75381,Q9H9S5,P40855,Q14118,Q10713,Q9NX14,O60826 9 +Spinal cord lesion 0.6684182839111864 1.3996771801564338 0.1616100103081166 1.0 0.7660069670636122 5 O75298 1 +Joint subluxation 0.6433312349881916 1.3985162524642778 0.1619580956167308 1.0 0.7660069670636122 6 P16278,Q9UHX1 2 +Abnormal peripheral nervous system physiology 0.3933605656896182 1.3983823786575411 0.1619982718665065 1.0 0.7660069670636122 48 Q9NR77,Q99720,P20700,O43681,Q9NQZ5,Q9Y3E5,Q9GZY8,O95831,O95721,O60313,Q9NZJ7,O15269,P07196 13 +Hallucinations 0.4009674040379543 1.3969569219793114 0.1624265256704444 1.0 0.7665414373043027 43 O75503,O43681,P50897,Q9Y276,O60313,P04062,O76024,Q9UJS0,Q9NZJ7,P35637,P21964,Q6DKK2 12 +Steppage gait 0.4528677823876907 1.395975571249655 0.1627218516066066 1.0 0.7665414373043027 21 Q9NR77,Q8TB36,P05023,Q13501,O95140,P02545,Q15120,O15269,O43819,P07196 10 +Decreased plasma carnitine 0.5247536287990361 1.3948832143137355 0.1630510597043082 1.0 0.7665414373043027 13 P09622,O43772,Q16836,O75880,P23786 5 +Aplasia hypoplasia involving bones of the feet 0.3580411720593258 1.3866124883284832 0.1655599581926317 1.0 0.7665414373043027 63 P13073,Q7LGA3,Q7RTS9,Q13510,Q5H8A4,P00813,Q9UHX1,Q9NX62,Q96A33 9 +Adrenal insufficiency 0.4355937940291619 1.386101841507126 0.1657158081546206 1.0 0.7665414373043027 26 O75381,Q13423,P38571,O95470,P16435 5 +Aortic valve stenosis 0.5752736418151589 1.3842679779165423 0.1662764153260179 1.0 0.7665414373043027 9 O75844,P16278 2 +Neurofibrillary tangles 0.7291399229781642 1.3837265659996083 0.1664421958588766 1.0 0.7665414373043027 4 Q709C8,O15118,O96008 3 +Abnormality of the musculature of the upper arm 0.5894278018967699 1.381123681423999 0.1672409353543482 1.0 0.7665414373043027 8 O14979,Q9BTV4,P50402 3 +Proximal upper limb amyotrophy 0.5894278018967699 1.381123681423999 0.1672409353543482 1.0 0.7665414373043027 8 O14979,Q9BTV4,P50402 3 +Abnormal electroretinogram 0.407702553838861 1.3801659271807356 0.1675355622685128 1.0 0.7665414373043027 35 O14773,P50897,O43924,P00846 4 +Cupped ribs 0.6181328358506333 1.37663538384934 0.1686250054342177 1.0 0.7665414373043027 7 Q96L58,P00813 2 +Hepatic encephalopathy 0.7274085632206752 1.3762588287111124 0.1687415145853532 1.0 0.7665414373043027 4 P09622,Q9UJS0 2 +Peripheral hypermyelination 0.8976908274534998 1.373906320045557 0.1694707673243185 1.0 0.7665414373043027 2 P07196 1 +Ophthalmoparesis 0.3698994231329922 1.370225837356995 0.1706164152973819 1.0 0.7665414373043027 79 O95169,Q9GZY8,Q9P0J0,Q96CU9,O60313,P21912,P04062,O76024,Q10713,Q7KZN9,O43819,Q96IX5,P00846,P00403 14 +Lumbar hyperlordosis 0.4806786704589965 1.3700171811806865 0.1706815384401527 1.0 0.7665414373043027 17 Q7RTS9,Q9H9S5,Q96HY6,P04066,O95140,Q14118 6 +Widely patent fontanelles and sutures 0.6617040705372895 1.3685309851630136 0.1711459300098887 1.0 0.7665414373043027 5 P98175,O75844 2 +Myoclonic seizure 0.3849102790414087 1.3669253987263048 0.1716486899939293 1.0 0.7665414373043027 51 Q01105,O75503,Q5XKP0,Q13510,P04062,P21912,P16278,Q9NZJ7,P00846 9 +Sea blue histiocytosis 0.8799785310960184 1.366925302796829 0.1716487200654777 1.0 0.7665414373043027 3 P16278 1 +Abnormal systemic blood pressure 0.3778695096508629 1.3664000238423837 0.1718134413239822 1.0 0.7665414373043027 87 Q04656,P04062,Q96MF7,P06280,O43772,P16435,P21912,Q9Y2U8,Q10713,Q15645,Q8TAA9,Q9NZJ7,P21964,O75844,P42892,P00403,Q9Y4P3,P20700,O43681,Q13423,P38571,Q9H6U8 22 +Rhizomelia 0.5307698559395351 1.3651380539663542 0.1722096635948073 1.0 0.7665414373043027 12 Q7RTS9,O75718,Q9H6U8,Q15392,O00116,Q9BV10 6 +Aplasia involving bones of the extremities 0.6608098107535678 1.3643794679254404 0.1724481665397972 1.0 0.7665414373043027 5 P02545,Q04656 2 +Dysesthesia 0.6607901860326286 1.3642883539693225 0.1724768297987131 1.0 0.7665414373043027 5 Q8NCH0 1 +Back pain 0.4328442672545805 1.3630767344031312 0.1728583282866895 1.0 0.7665414373043027 26 P01889,Q5HYI8,Q8WVX9,P20936,P02545,P35670,Q8TAA9,Q9BTV4,Q969G3,P50402,Q9UGP8 11 +Lower limb amyotrophy 0.4705608157356367 1.362700577101449 0.1729768958935433 1.0 0.7665414373043027 18 Q9NR77,Q9NVI7,O95140,Q8TD16,P07196,O75298 6 +Abnormal circulating acetylcarnitine concentration 0.6355744025015839 1.3610285770642478 0.1735046587248425 1.0 0.7666601426426873 6 O43772,P23786 2 +Fasting hyperinsulinemia 0.7233237143617239 1.358634230039664 0.1742625227314411 1.0 0.7692685017885061 4 P02545 1 +Contractures of the joints of the upper limbs 0.36351542747485 1.3564590370659766 0.174953160204804 1.0 0.7704918537817381 74 Q9NR77,Q99720,Q7LGA3,O75844,P16435,Q9Y3E5,P37268,O94905,P50402,Q15392,Q02127,Q9BTV4,P35637,P07196,P23786,Q96L58,P42892 17 +Vertebral hypoplasia 0.5546248764440183 1.3535577692075549 0.1758775077825343 1.0 0.7733365977143164 10 Q14739,Q96HY6,Q15738,P16278,Q8TAA9 5 +Postaxial foot polydactyly 0.5535913350735042 1.3476679752514225 0.177765196704694 1.0 0.7748787852900507 10 O43924,Q10713 2 +Abnormality of the 5th toe 0.5535913350735042 1.3476679752514225 0.177765196704694 1.0 0.7748787852900507 10 O43924,Q10713 2 +Nasogastric tube feeding in infancy 0.5683490563839525 1.346251875810326 0.1782213001755073 1.0 0.7748787852900507 9 P61978,Q969N2,Q9UHX1,O75648,Q9NZJ7 5 +Bifid scrotum 0.6314673436091893 1.3411497285531269 0.1798718444224167 1.0 0.7748787852900507 6 Q96EK5,P16435,Q69YQ0 3 +External ophthalmoplegia 0.4675801675854386 1.341089962590338 0.1798912457935813 1.0 0.7748787852900507 18 P21912,P00403,O60313 3 +Inability to walk 0.3758062945843378 1.3410742574057026 0.1798963443065573 1.0 0.7748787852900507 87 O75503,Q99720,Q96N66,Q9NR77,Q7RTS9,Q9NVI7,Q13510,Q15043,Q9GZY8,Q96CU9,P21912,O14949,O15269,P07196,Q15041,P00846 16 +Congestive heart failure 0.3536887422399613 1.3409424033243211 0.1799391534984737 1.0 0.7748787852900507 66 P06280,O95169,Q70HW3,P07437,Q9Y4P3,Q9BUB7,P10253,O95721,P22626,P21912,O75880,P02545,Q9NX14,P16278,O43819,Q9BTV4,P00403,Q96MF7 18 +Abnormal pelvis bone morphology 0.8729547641963409 1.3394380691116547 0.1804281031311401 1.0 0.7748787852900507 3 P16435,Q7RTS9 2 +Short lingual frenulum 0.7181041233996759 1.3361032501506225 0.1815155278284297 1.0 0.7751073590531944 4 O75844,P02545 2 +Pneumothorax 0.6098381195027671 1.3348828439064555 0.181914693651001 1.0 0.7751073590531944 7 Q8NCH0,Q96L58 2 +Fatigable weakness of swallowing muscles 0.4922363957603028 1.3335893444718945 0.1823384769717817 1.0 0.7751073590531944 15 Q92804,Q15165,P35637,Q9UHD9 4 +Abnormal intraocular pressure 0.6295992101862629 1.3321012054982897 0.1828269342744817 1.0 0.7755721316256815 6 Q8NCH0 1 +Abnormality of thalamus morphology 0.4446632622171875 1.3320656933303558 0.1828386024008905 1.0 0.7755721316256815 21 O95169,O75306,Q9H9S5,P02792,Q99496,Q9GZY8,Q9UPT5,O43819,Q969G3 9 +Abnormal vascular physiology 0.3870261072018427 1.3317127106269058 0.1829546108801161 1.0 0.7755721316256815 48 P06280,P20674,Q6NUK1,Q14108,Q9NZ08,P04062,O96000,O75844,P00403 9 +Abnormal upper motor neuron morphology 0.5503040624034995 1.328920296178543 0.1838742669766899 1.0 0.7787516233302432 10 Q99720,Q8IY17,Q13501,O94905,P35637 5 +Focal t2 hyperintense basal ganglia lesion 0.4412876028154482 1.3269765242333968 0.184516448457048 1.0 0.7806091799017868 22 Q96CU9,P00846,Q9P0J0 3 +Generalized myoclonic seizure 0.3963742034760159 1.3258762545711764 0.1848806894724044 1.0 0.7806091799017868 41 Q01105,Q13510,P04062,P21912,P16278,Q9NZJ7,P00846 7 +Raynaud phenomenon 0.6277937062049515 1.323352356426979 0.185718227933556 1.0 0.7815776787569373 6 O75844,P02545 2 +Broad palm 0.6074434972854583 1.3228099928009642 0.1858985732490421 1.0 0.7815776787569373 7 Q7RTS9,Q14739,O95831 3 +Episodic pain 0.5335172491106112 1.3206748802223582 0.1866097933230213 1.0 0.7815776787569373 11 P23786,Q13423 2 +Abnormality of the umbilical cord 0.6270744486159334 1.3198660991616509 0.1868797279575988 1.0 0.7815776787569373 6 O75844,P16435,P02545 3 +Limited elbow extension 0.5232074503685176 1.3190464946731022 0.187153569082261 1.0 0.7815776787569373 12 Q9H6K4,P16435,Q7RTS9,Q96L58 4 +Atrophy degeneration involving the spinal cord 0.563149859356314 1.3176490779227568 0.1876211483529979 1.0 0.7815776787569373 9 Q13217,P07196 2 +Abnormality of the calf 0.365005096775457 1.31341989304655 0.1890414978620125 1.0 0.7815776787569373 58 Q9NR77,P08236,Q7LGA3,Q7RTS9,O75431,Q32P28,P16435,Q96HY6,Q04656,O95831,P16278,Q9NX62,Q9BV10,Q96L58 14 +Cachexia 0.4811050748712651 1.3131542440062345 0.1891309785859969 1.0 0.7815776787569373 16 Q99720,P38571,P04062,P02545,Q9NZJ7,P35637 6 +Abnormality of the phalanges of the toes 0.4891664208445535 1.3130093677933423 0.1891797915731241 1.0 0.7815776787569373 15 O75844,Q7LGA3 2 +Elevated hemoglobin a1c 0.866199455479918 1.3130085446025792 0.1891800689564373 1.0 0.7815776787569373 3 Q96MF7 1 +Meningitis 0.6495166158085789 1.3118946385478951 0.1895556867725707 1.0 0.7815776787569373 5 P02786,Q8TAA9,Q9NZ08 3 +Abnormality of the odontoid process 0.5763717286423617 1.3118274121954383 0.1895783735960585 1.0 0.7815776787569373 8 Q7RTS9,P16278,O95831 3 +Abnormal elasticity of skin 0.3502000014773568 1.3108625492521242 0.1899042055955768 1.0 0.7815776787569373 65 Q9Y487,Q6NUK1,Q9BV10,Q9NWM8,P07437,Q9Y4P3,Q04656,Q9UHX1,P04062,O96000,Q9NX14,Q8NCH0,P38435,O75844,Q96L58,Q15904 16 +Metaphyseal striations 0.6251221983188446 1.3104007469473842 0.1900603010773893 1.0 0.7815776787569373 6 P00813 1 +Erythema 0.4538963869480959 1.309041082672484 0.1905204348957601 1.0 0.7815776787569373 19 P98194,P22830,P51648,Q06136,P00403 5 +Tinnitus 0.488432859737648 1.3080877620223572 0.1908435438421278 1.0 0.7815776787569373 15 Q9NR77,Q9NR28,Q15043,O95831,P21912 5 +Contractures of the joints of the lower limbs 0.3668751121370384 1.307770448838571 0.1909511802146883 1.0 0.7815776787569373 57 Q99720,Q7LGA3,O75477,Q86XL3,O00459,Q9Y3E5,P37268,O60313,O94905,P21912,Q9HC21,Q8TD16,Q14118,P35637,P23786,P50402 16 +Micrographia 0.7115325383980203 1.3077228735033857 0.1909673221803089 1.0 0.7815776787569373 4 P02792,P04062 2 +Wormian bones 0.4629576952610121 1.307512002445431 0.1910388812897445 1.0 0.7815776787569373 18 Q9Y487,Q32P28,O95831,Q04656,P02545,Q8NC56,O75844 7 +Limited wrist movement 0.6484844639028795 1.3070929410668422 0.1911811483750922 1.0 0.7815776787569373 5 Q9H6K4 1 +Degeneration of the lateral corticospinal tracts 0.6244082017787426 1.306937998943985 0.1912337693906312 1.0 0.7815776787569373 6 P35637,O75298 2 +Cerebral calcification 0.3998950357233652 1.306084139205867 0.1915239460829336 1.0 0.7815776787569373 35 Q16625,O60313,Q14118,O00584,P23786,P00403,O75845 7 +Neurodegeneration 0.4012767088811276 1.3025970953310166 0.1927123499632481 1.0 0.7815776787569373 32 P08236,P17900,Q9UHD9,Q92804,P35637,Q15165,Q6DKK2 7 +Increased blood pressure 0.3570565550038139 1.302594842001169 0.192713119658648 1.0 0.7815776787569373 72 P06280,Q15645,P38571,Q9Y4P3,P16435,Q9H6U8,P04062,P21912,Q9Y2U8,Q10713,Q8TAA9,P21964,O75844,P42892,P00403,Q96MF7 16 +Sepsis 0.4379865211702393 1.3008107174740904 0.1933232525505068 1.0 0.7833601522148076 22 Q9BV10,P42892,P00813,Q9BT22 4 +Abnormal conjunctiva morphology 0.4249232780462928 1.2965273086543183 0.1947938778957629 1.0 0.787688247583243 26 P06280,Q9NW15,Q13510,P04066,P21912,P10619 6 +Progressive hearing impairment 0.49813773829092 1.2964378169955852 0.194824690398855 1.0 0.787688247583243 14 P00403,O60313 2 +Aplasia hypoplasia of the nipples 0.4701641002897103 1.2957802237294809 0.1950512132814781 1.0 0.787688247583243 17 Q6NUK1,Q5H8A4,P07437,Q9H6U8,O96028,O95202,Q96A33,P10586 8 +Nuclear cataract 0.6220161608059993 1.2953333298072822 0.1952052662089145 1.0 0.787688247583243 6 P08670,O76024 2 +Duplication involving bones of the feet 0.4419733208083179 1.2916671766405134 0.196472429154763 1.0 0.791232387938173 20 O95202,P21964,O43924,Q10713 4 +Poor motor coordination 0.5080099539124233 1.2897334033880758 0.1971432375587236 1.0 0.791691404431036 13 O75503,Q10713,O95140,P35670 4 +Aplasia hypoplasia involving the skeletal musculature 0.5183660787236838 1.289467872046632 0.1972354787349319 1.0 0.791691404431036 12 Q9NR77,Q9Y487,Q9H6U8,O43505 4 +Acquired abnormal hair pattern 0.6005613945182878 1.288068288540757 0.1977221929358801 1.0 0.791691404431036 7 O75844,P02545 2 +Eeg with spike wave complexes 0.4854284618646881 1.2879146820235694 0.1977756640649315 1.0 0.791691404431036 15 O75503,Q14108 2 +Impairment of activities of daily living 0.3757008678337004 1.2875200335314376 0.1979130915133848 1.0 0.791691404431036 52 Q99720,O15269,P20700,P21964,Q3ZCQ8,Q8TAA9,Q9NZJ7,P35637,P07196,O75298,Q9UQN3 11 +Choreoathetosis 0.3971300386703868 1.2866024168932304 0.1982329008738206 1.0 0.791691404431036 36 Q9H6K4,Q5XKP0,P00846 3 +Abnormal lung lobation 0.5178054862733987 1.2860394928883443 0.1984292790937127 1.0 0.791691404431036 12 P21964,Q9H6U8,Q9UHX1 3 +Cognitive impairment 0.4476405217016276 1.2857277782666792 0.1985380831246692 1.0 0.791691404431036 172 Q99720,Q9Y487,Q5XKP0,O75381,O15118,P04062,Q9Y2R0,P35637,P06280,Q14108,O95169,Q13510,Q9UHD9,P50897,P21912,P40855,Q9UJS0,Q10713,Q9H6K4,P07196,P00846,Q9UQN3,O75503,Q13217,P17900,O95831,O60313,P35670,Q9NZJ7,O43819,P21964,P00403,P20700,Q9BVA1,P13473,Q9NZ08,O43681,O95470,Q9NQZ5,P22626,O95140,O76024,P16278,Q9NPL8,P54802,P06865,Q6DKK2 47 +Chondrocalcinosis 0.6437896138207573 1.285243185042675 0.1987073170645881 1.0 0.791691404431036 5 P35670,Q04656 2 +Aplasia hypoplasia of the sacrum 0.8583148265831511 1.2821752138604643 0.1997811889885214 1.0 0.791691404431036 3 Q8TAA9 1 +Elbow flexion contracture 0.4116461231796957 1.2792378917327951 0.2008132962174607 1.0 0.791691404431036 29 Q7LGA3,P16435,P37268,Q96L58,P23786,P50402 6 +Spastic tetraparesis 0.4294216257140611 1.279105818401459 0.2008597949771633 1.0 0.791691404431036 24 Q7RTS9,P17900,P20700,O94905,P21912,Q9NZJ7,P00846 7 +Atlantoaxial instability 0.8742783835792257 1.277051024813432 0.2015842337227369 1.0 0.791691404431036 2 Q7RTS9 1 +Unilateral renal agenesis 0.4587359122318272 1.2767801134853751 0.2016798882980368 1.0 0.791691404431036 18 Q86XL3,Q7LGA3,Q9UHX1 3 +Abnormality of the anterior fontanelle 0.4071737728782397 1.2759566945639342 0.2019708278738772 1.0 0.791691404431036 30 Q9Y487,Q6NUK1,P20674,O75381,Q16134,Q32P28,P16435,Q9H6U8,Q04656,P40855 10 +Abnormal morphology of the musculature of the neck 0.4754323939205636 1.274060190639826 0.2026420854329997 1.0 0.791691404431036 16 Q99720,O75569,Q9H6U8,P22307,P19367,P35637,P04350,Q96L58 8 +Pericardial effusion 0.5692516054887267 1.2739232188678211 0.2026906287278365 1.0 0.791691404431036 8 Q9H6U8,P04062,Q14108 3 +Hypokinesia 0.5255436702423036 1.2733223754382426 0.2029036699175788 1.0 0.791691404431036 11 O95831,P12235,P13473,P04062 4 +Depletion of mitochondrial dna in muscle tissue 0.641185665420616 1.2731187886208797 0.2029758927228155 1.0 0.791691404431036 5 Q9UBX3 1 +Abnormality of the spleen 0.3985552021361074 1.2725401627620572 0.2031812635591161 1.0 0.791691404431036 116 Q9BT22,Q16625,O15118,P04062,O95202,Q14108,Q13510,Q9Y2U8,Q9UJS0,Q10713,Q15904,Q5HYI8,P00813,P35670,Q9NZJ7,P21964,P10619,O75845,P08236,Q9NZ08,P38571,Q9H6U8,P04066,P16278,P15586,P54802,Q96A33 27 +Abnormality of metacarpal epiphyses 0.6410443268439419 1.272460587762886 0.2032095188296496 1.0 0.791691404431036 5 O95202,P16435 2 +Ulnar deviation of the wrist 0.7032403887516214 1.2718976196465734 0.2034094977203211 1.0 0.791691404431036 4 P16435,P16278 2 +Limited knee extension 0.8726747915330431 1.2704320630502577 0.2039307681959132 1.0 0.791691404431036 2 Q7RTS9 1 +Large iliac wing 0.8726747915330335 1.2704320630502175 0.2039307681959274 1.0 0.791691404431036 2 Q96L58 1 +Pruritus 0.4312375275770327 1.269500651903474 0.2042625581808268 1.0 0.791691404431036 23 P16615,P22830,P38571,P00813,Q96A33 5 +Oculomotor apraxia 0.4282245680676475 1.269313406680664 0.2043293066027198 1.0 0.791691404431036 24 O14773,O43924,Q10713 3 +Abnormality of facial adipose tissue 0.7024849518395286 1.2686333592408314 0.204571860634247 1.0 0.791691404431036 4 O75844,Q03252 2 +Abnormality of the shoulder girdle musculature 0.3958572291923395 1.267614393912371 0.2049356891325409 1.0 0.791691404431036 35 Q9Y487,P12235,Q9H9S5,O60313,O14979,Q8TD16,P02545,Q9NZJ7,P07196,Q9BTV4,P50402,Q9H0W5 12 +Malrotation of small bowel 0.7020229980882808 1.266637222752599 0.2052850364443732 1.0 0.791691404431036 4 Q8NCH0,O95202 2 +Generalized osteosclerosis 0.871391917896087 1.2651385806618654 0.2058216548930724 1.0 0.7927241758507514 2 Q9Y2U8 1 +Inappropriate behavior 0.4568054002198888 1.262707615470615 0.206694276176391 1.0 0.7954177887056255 18 Q05086,P17900,Q9H6U8,Q13501,Q8WXI9,Q96S52,P35670,Q9NZJ7,Q9UQN3 9 +Thoracic kyphosis 0.4928417111552203 1.2619826532255516 0.2069550283993175 1.0 0.7957542172372419 14 Q7RTS9,P51648,O95831,Q9UHX1,P04062 5 +Orthostatic hypotension due to autonomic dysfunction 0.5665911485346784 1.2597418411475294 0.2077625062147228 1.0 0.7970254579747773 8 P04062,P20700,Q9NZJ7 3 +Pulmonary hypoplasia 0.4093723465587049 1.259092321149032 0.2079969876908616 1.0 0.7970254579747773 29 Q6NUK1,Q14739,Q16134,P98175,Q9H6U8,Q15738,O96000,P02545,Q8TAA9,O75844,Q96L58 11 +Varicose veins 0.638054643453364 1.258535529580206 0.2081981462346633 1.0 0.7970254579747773 5 P21964 1 +Abnormality of the larynx 0.3800121438245661 1.257507262443092 0.2085700109166044 1.0 0.7970254579747773 48 Q13510,Q9UHD9,Q92804,P16435,Q96HY6,Q9UHX1,Q9NZJ7,P35637,Q15165,P21964 10 +Enlarged thorax 0.4469099207772716 1.2566575634724455 0.208877660894982 1.0 0.7970254579747773 19 P08236,Q7RTS9,Q32P28,P04066,O75844,Q9H0W5 6 +Delusions 0.4645178390395045 1.255767832409495 0.2092001575408557 1.0 0.7970254579747773 17 P04062,P21964,Q9UJS0,Q9NZJ7 4 +Decreased calvarial ossification 0.6995038604532304 1.25575161400502 0.2092060394952239 1.0 0.7970254579747773 4 O75844,P02545 2 +Tubulointerstitial nephritis 0.5941704123407437 1.255750950809735 0.2092062800198548 1.0 0.7970254579747773 7 P23786 1 +Dermal atrophy 0.4163997402022577 1.2542628806686893 0.2097464710698187 1.0 0.7970254579747773 27 Q9NWM8,Q15392,Q9Y2U8,Q9NX14,Q8NCH0,O75844,Q96L58 7 +Leukodystrophy 0.3621138009663186 1.2526061910226134 0.2103490606565836 1.0 0.7970254579747773 57 O95169,P20700,Q86Y39,Q9P0J0,Q96CU9,Q9Y6M9,P21912,O96000,Q14118,Q9NX14,Q9NZJ7,Q7KZN9,O43819,Q9NPL8,Q15067,Q8IUX1 16 +Polycystic liver disease 0.6366632621781887 1.252053437366903 0.2105503928215744 1.0 0.7970254579747773 5 Q9H6U8 1 +Proportionate short stature 0.3953857425724624 1.2519938414932588 0.2105721080413773 1.0 0.7970254579747773 33 Q5JRA6,Q7RTS9,Q96HY6,P10619,Q15392,P21912,P16278,Q9NX14,Q96L58,Q96MF7 10 +Distal amyotrophy 0.3522906285124694 1.2504035534783182 0.2111521671657579 1.0 0.7970254579747773 61 Q99720,Q8TB36,Q9Y3E5,Q04656,P04792,O15269,P35637,Q13510,Q8IY17,Q9BQT8,Q13501,P21912,P02545,P07196,Q9NR77,Q9Y4W6,Q15120,Q92734,P43243,Q9NVI7,O95140,Q8TD16,Q96RL7 23 +Urinary incontinence 0.387466473074109 1.2483438127671025 0.2119051759037657 1.0 0.7970254579747773 42 P07686,Q99720,Q9NZJ7,Q10471,O43681,Q13501,Q8WVX9,O75962,Q3ZCQ8,Q9UBB4,Q8TAA9,P35637,P07196,Q969G3,Q9UQN3,O75298,Q8WWI5 17 +Dental crowding 0.4191415982745909 1.2477595155924226 0.2121191386445144 1.0 0.7970254579747773 26 Q01105,P36543,O75431,Q15233,Q15738,O75962,Q92643,P02545,O75844,Q96A33 10 +Specific learning disability 0.3483681667095249 1.2473298994479791 0.212276558563121 1.0 0.7970254579747773 68 Q96DF8,Q9H9S5,Q04656,P35637,Q96EK5,Q9Y2U8,Q10713,Q9H6K4,P04350,Q9UQN3,O75962,Q9NX14,P21964,Q9BPX6,P00403,O43505,O75845,Q9BVA1,P22626,Q14118 20 +Narrow mouth 0.3472909492337473 1.2472749294006658 0.2122967067727743 1.0 0.7970254579747773 67 Q9Y487,Q7LGA3,Q6NUK1,Q9NVI7,O75431,P07437,P16435,Q8NC56,P04062,Q15392,Q9NX62,Q8NCH0,P21964,O75844 14 +Protruding tongue 0.5011125235158518 1.2462158898484448 0.2126851470022961 1.0 0.7970254579747773 13 P83436,P20700,Q6NUK1,Q05086,Q10713,O60826 6 +Aganglionic megacolon 0.4545157949743991 1.246002189853664 0.2127635912315326 1.0 0.7970254579747773 18 P21964,Q10713 2 +Neck flexor weakness 0.6970902030615589 1.2453216450759217 0.2130135423750554 1.0 0.7970254579747773 4 Q99720 1 +Abnormal vertebral morphology 0.3915975368616275 1.2451932255361309 0.2130607321938762 1.0 0.7970254579747773 111 Q6NUK1,Q9UM00,Q04656,P04062,Q02127,O95202,Q96L58,Q14108,P16435,Q10713,Q8NCH0,Q7RTS9,P00813,O95831,Q8TAA9,Q9BV10,P10619,O75845,P08236,Q32P28,Q5H8A4,Q9UHX1,P04066,P16278,P15586,P54802 26 +Wide cranial sutures 0.5638107202184027 1.2449110621721304 0.2131644441534217 1.0 0.7970254579747773 8 P98175,O75844,P02545 3 +Reduced subcutaneous adipose tissue 0.5499407767569255 1.2447761476752457 0.2132140461987226 1.0 0.7970254579747773 9 Q8NC56,O75844,Q6NUK1,P02545 4 +Scaphocephaly 0.6967265725288827 1.243750317681358 0.2135914706763202 1.0 0.7972345055894197 4 P40855,P48444,Q969X5 3 +Hypoparathyroidism 0.5003899463755707 1.241650885352544 0.2143653985032398 1.0 0.7982883688281814 13 P21964,P00403 2 +Lipodystrophy 0.3930923926469362 1.2412142565963808 0.2145266095801969 1.0 0.7982883688281814 35 Q9Y487,Q6NUK1,O75431,O75844,Q9H6U8,Q03252,P04066,P42167,Q9BTV4,P50402 10 +Morphological abnormality of the corticospinal tract 0.4784700887338207 1.241098559711269 0.2145693415669736 1.0 0.7982883688281814 15 P35637,P00846,O75298 3 +J shaped sella turcica 0.6959945184587257 1.2405869634538709 0.2147583702995934 1.0 0.7983446785792984 4 P08236 1 +Gastrointestinal hemorrhage 0.4070588434005455 1.238567495650268 0.2155057117502614 1.0 0.799291417259593 29 P01889,Q14739,Q9NZ08,Q04656,Q9UHX1,P21912,O76024,Q9UJS0,P21964,P49257,Q9UGP8 11 +Focal segmental glomerulosclerosis 0.4300718716371843 1.2378937455782422 0.2157554617338091 1.0 0.799291417259593 22 Q14108,Q8NFH4,O75431,O95470,P00403 5 +Xerostomia 0.4619272653042168 1.2373779501775888 0.2159468008983271 1.0 0.799291417259593 17 Q14739,Q9UHD9,Q92804,Q13501,P55011,P35637,Q15165,Q9UQN3 8 +Spastic paraparetic gait 0.6099750298846012 1.2368390650362613 0.2161468359033427 1.0 0.799291417259593 6 Q15043,Q15041 2 +Abnormal sharpey fiber morphology 0.6098784105240647 1.2363692315588657 0.2163213476527006 1.0 0.799291417259593 6 P35670,P02545,Q04656 3 +Proximal amyotrophy 0.4698997080095225 1.2358424295605916 0.2165171399920353 1.0 0.799291417259593 16 Q9H9S5,O14979,P02545,P35637,P07196,Q9BTV4,P50402 7 +Temperature instability 0.609542901498491 1.2347376916907915 0.2169281433033005 1.0 0.799291417259593 6 Q9HC21,Q9NZJ7 2 +Increased connective tissue 0.5616814496341022 1.2335470453977395 0.2173717358827966 1.0 0.7993481429108212 8 P07196,P02545,O95831,O75431 4 +Submucous cleft of soft and hard palate 0.4266721624878596 1.2326444306113709 0.2177084526032446 1.0 0.7993481429108212 23 Q96DF8,O43505,Q7LGA3,Q15392,P02545,Q14118,O75844 7 +Type ii transferrin isoform profile 0.6941251620275095 1.2325092163306473 0.2177589260110539 1.0 0.7993481429108212 4 Q15904 1 +Emg abnormality 0.3576211063331783 1.2309448859116363 0.2183434782203914 1.0 0.8003697168711007 78 O14773,Q8TB36,Q9NW15,Q9H9S5,P42166,Q04656,P42167,O15269,P50402,Q8NI60,Q13510,Q969X5,Q13501,P02545,P07196,Q16637,Q9NR77,P12235,O60313,Q15120,Q9NZJ7,O43819,Q9BTV4,P13473,O43681,P22626,O95140,Q96RL7 28 +Decerebrate rigidity 0.8447224895732997 1.2290786094568031 0.219042334278952 1.0 0.8003697168711007 3 P16278,Q9NZJ7 2 +Axonal degeneration regeneration 0.6931964056482535 1.228496027282055 0.2192608198040593 1.0 0.8003697168711007 4 Q8TB36,O95140,P02545 3 +Aplasia cutis congenita of scalp 0.5884362955748382 1.226714803717016 0.219929801694072 1.0 0.8003697168711007 7 Q5H8A4,O95202,Q9H6U8 3 +Agenesis of cerebellar vermis 0.8438151989242704 1.2255377403579573 0.2203726794543108 1.0 0.8003697168711007 3 Q10713 1 +Abnormality of lower limb epiphysis morphology 0.4599677549319236 1.2234552919437816 0.2211577805400923 1.0 0.8003697168711007 17 Q7LGA3,Q7RTS9,Q96L58,O95831 4 +Hypoplasia of the iris 0.6300486186795411 1.2212269707671632 0.2220000951363474 1.0 0.8003697168711007 5 O95202,Q7LGA3 2 +Abnormality of circulating leptin level 0.6913898793722614 1.2206902217311983 0.2222033314374822 1.0 0.8003697168711007 4 O75844,P02545 2 +Sensory axonal neuropathy 0.475392852129981 1.2203556370648123 0.2223300869965268 1.0 0.8003697168711007 15 P22626,Q8IV08,Q15067,O95831 4 +Limb girdle muscle atrophy 0.4863998767616424 1.219982488071027 0.2224715134992276 1.0 0.8003697168711007 14 O14979,Q14118,P02545,Q9BTV4,P50402 5 +Flared iliac wing 0.6063511470070402 1.219212738946048 0.2227634581230952 1.0 0.8003697168711007 6 Q96L58,P16278 2 +Atrophy degeneration involving the corticospinal tracts 0.4964914814504188 1.2170029727229947 0.2236030848153358 1.0 0.8003697168711007 13 P35637,P00846,O75298 3 +Papule 0.4590339450862697 1.2168167297736434 0.2236739533017748 1.0 0.8003697168711007 17 P16615,P21912,Q9Y2U8,P38435,O75844 5 +Axonal degeneration 0.6057843968329466 1.2164553279161434 0.2238115184423426 1.0 0.8003697168711007 6 Q9BQT8,Q8TB36,Q6DKK2 3 +Hypotension 0.4298240094078089 1.2157694576356286 0.2240727566058742 1.0 0.8003697168711007 21 O43772,P20700,O43681,Q13423,Q04656,P04062,Q9NZJ7,Q9NRG9 8 +Aplasia hypoplasia of the femur 0.4744385863797017 1.2139185749623378 0.2247788190266582 1.0 0.8003697168711007 15 O75431,O95831,Q9UHX1,O00116,Q9BV10,Q96L58 6 +Fatigable weakness of bulbar muscles 0.4585733293524501 1.2135413017220955 0.2249229335333078 1.0 0.8003697168711007 17 Q92804,Q15165,P35637,Q9UHD9 4 +Abnormal circulating proline concentration 0.8407124265784987 1.2134323534480322 0.2249645629365768 1.0 0.8003697168711007 3 P20674 1 +Axial dystonia 0.8406444834703496 1.2131673426338483 0.2250658471968178 1.0 0.8003697168711007 3 Q99720 1 +Chronic fatigue 0.5855955713156722 1.212317285155078 0.2253909497467643 1.0 0.8004986984017471 7 Q13423,Q9NZJ7 2 +Proximal muscle weakness in upper limbs 0.4740971770847252 1.2116150636317378 0.2256597655954009 1.0 0.8004986984017471 15 P07196,O95140,P50402,Q9BTV4 4 +Bowing of the legs 0.374023324799317 1.210984966680974 0.2259011663632253 1.0 0.8004986984017471 49 Q9NR77,P08236,Q7LGA3,Q7RTS9,O75431,Q32P28,P16435,Q96HY6,Q04656,P16278,Q9NX62,Q96L58 12 +Hyporeflexia of upper limbs 0.839910170035288 1.2103033579946976 0.2261625096274584 1.0 0.8004986984017471 3 Q9NR77,Q15067 2 +Decreased light and dark adapted electroretinogram amplitude 0.8395518034492307 1.2089057774515437 0.2266990463011473 1.0 0.8005058384674094 3 P50897 1 +Abnormal circulating fatty acid anion concentration 0.4845652360496898 1.2080039523962218 0.2270457420642446 1.0 0.8005058384674094 14 P09622,O43772,Q16836,O75880,P23786 5 +Demyelinating peripheral neuropathy 0.4655715696598184 1.2058890786758991 0.2278602622166416 1.0 0.8005058384674094 16 Q9NR77,Q13217,P41440,P07196,P00846 5 +Increased total bilirubin 0.687780260639969 1.2050948953239171 0.2281666702176221 1.0 0.8005058384674094 4 P23786 1 +Bone marrow foam cells 0.8384770526710481 1.2047149111583757 0.2283133776458505 1.0 0.8005058384674094 3 O15118 1 +Abnormal circulating non proteinogenic amino acid concentration 0.6031871879080705 1.2038166557830123 0.228660450611716 1.0 0.8005058384674094 6 P00846 1 +Foot dorsiflexor weakness 0.3901644206158567 1.202741853859577 0.2290762320995738 1.0 0.8005058384674094 33 Q9NR77,Q99720,Q8TB36,Q9BQT8,P05023,Q13501,O95140,P02545,O15269,O43819,P07196 11 +Microcornea 0.4029766056230368 1.2022865003767895 0.2292525453915608 1.0 0.8005058384674094 29 O43505,P07437,Q14118,Q8NCH0,Q96L58,O75845 6 +Abnormality of the radioulnar joints 0.8376782061349042 1.2016004110381513 0.2295183821608719 1.0 0.8005058384674094 3 Q96L58 1 +Radioulnar dislocation 0.8376782061349042 1.2016004110381513 0.2295183821608719 1.0 0.8005058384674094 3 Q96L58 1 +Urinary retention 0.6021514780594923 1.1987755657557753 0.2306152259641947 1.0 0.8025795535975134 6 P20700,Q8TAA9 2 +Macular purpura 0.4933953731905353 1.197406524955735 0.2311481416547205 1.0 0.8027239926904856 13 Q8NCH0,P38435,Q16625 3 +Hand muscle weakness 0.5032511963352377 1.1968063405327622 0.2313820463454483 1.0 0.8029289302887025 12 Q9NR77,Q13501,O95140,Q8TD16,P07196 5 +Fatigable weakness of respiratory muscles 0.4640081347881134 1.1950578522389688 0.2320644277693291 1.0 0.8030154438832703 16 Q92804,Q15165,P35637,Q9UHD9 4 +Blurred vision 0.624416026989455 1.1949670126655327 0.2320999186688501 1.0 0.8030154438832703 5 O75306,P00846 2 +Gastric ulcer 0.8359720038905776 1.1949498606995557 0.2321066203513613 1.0 0.8030154438832703 3 O76024 1 +Spinal muscular atrophy 0.4818651410063264 1.1903621328930496 0.2339040896397046 1.0 0.8061964531050182 14 Q99720,Q8TD16,Q13510 3 +Polymicrogyria 0.3510781383212084 1.1883362838462028 0.2347009481399673 1.0 0.8077301745956448 75 Q01105,Q96N66,Q9Y487,O43505,Q9BVA1,O75381,P07437,O00459,Q16625,P37268,O95721,Q15392,P40855,Q8TD16,Q10713,Q14118,P23786,Q9Y320 18 +Abnormality of the musculature of the thigh 0.5396107714841893 1.187612173630919 0.2349862394743689 1.0 0.8081062362747773 9 O14979,P07196,Q9BTV4,P50402 4 +Molar tooth sign on mri 0.6221120080600469 1.1842236823806138 0.2363245298217762 1.0 0.8108863351358554 5 Q10713 1 +Hand tremor 0.5009777883737435 1.18283276468432 0.2368754325039344 1.0 0.811563515392211 12 O94905,O95140,Q15120,Q92734,P07196,Q16637 6 +Polar cataract 0.8325689546704393 1.181691630048963 0.2373280806290338 1.0 0.8119025470699661 3 Q7LGA3 1 +Abnormal urine carbohydrate level 0.509971153210296 1.180494601698119 0.2378035562388691 1.0 0.8123185466463158 11 P04066,P16278,Q9UJS0 3 +Dysplasia of the femoral head 0.8317842199455008 1.178635583394618 0.2385433161088372 1.0 0.8142396760265219 3 Q96L58 1 +Abnormal urine protein level 0.3435914152734684 1.1751226478308126 0.2399456510323094 1.0 0.8153889592075003 62 P06280,Q14108,Q8NFH4,Q5JRA6,O75431,O95470,Q9H6U8,Q03252,O95721,P04062,P21912,P09601,P35670,P00403,Q9Y4P3 15 +Lower limb hyperreflexia 0.4356319083338018 1.1717591472544673 0.2412937687345384 1.0 0.8163393239594908 19 P13073,Q05086,Q14739,P02792,Q9Y4W6,Q15233,P21912,Q15041 8 +Transient ischemic attack 0.5774381521644222 1.1709322669648188 0.2416260039529265 1.0 0.8163393239594908 7 O75844 1 +Elevated circulating aspartate aminotransferase concentration 0.4788180212991966 1.1704358073101735 0.2418256328871504 1.0 0.8163393239594908 14 P38571,O75880,Q15904 3 +Abnormal gallbladder morphology 0.3954476502860281 1.1699480539403628 0.2420218739786765 1.0 0.8164014867274829 30 P22830,Q9Y4P3,P04062,P40855,Q9NZJ7,P21964,Q96A33,O75845 8 +Abnormal placenta morphology 0.5362363656477442 1.1689117384705014 0.2424391936002461 1.0 0.8172087649183039 9 O75844 1 +Dysmetric saccades 0.5492669597547495 1.1671921300202126 0.2431327884016951 1.0 0.8189454376758493 8 O14773,Q9NW15,O95140 3 +Hepatic fibrosis 0.3843628446007857 1.1635882391101775 0.2445909198267679 1.0 0.8218552618642885 36 Q13510,P38571,Q9H6U8,P04062,Q9UJS0,Q10713,Q15904 7 +Aspiration 0.5214345696026025 1.163450408262971 0.2446468076892676 1.0 0.8218552618642885 10 P17900 1 +Kinetic tremor 0.3861092216050984 1.1605383695665143 0.2458296812629419 1.0 0.8237985888161797 32 P41440,Q14108,Q9NW15,O75027,P20700,O43681,Q9BUB7,Q9NZJ7,Q8NC56 9 +Renal dysplasia 0.4510253629686398 1.159791899334733 0.2461335430119371 1.0 0.823825590207127 17 O43505,Q9H936,O95169,O75306,Q9H9S5,Q9NWS8,O43819 7 +Recurrent hand flapping 0.8454137267479158 1.158339001032108 0.2467257214401419 1.0 0.823825590207127 2 P55795 1 +Progressive peripheral neuropathy 0.8444515715202181 1.1544005382785605 0.2483359945954717 1.0 0.823825590207127 2 Q9NZJ7 1 +Vegetative state 0.8444515715202181 1.1544005382785605 0.2483359945954717 1.0 0.823825590207127 2 Q9NZJ7 1 +Dystrophic toenail 0.5927129069400031 1.1528127993844253 0.2489872296949045 1.0 0.823825590207127 6 Q969G3,O75844,P02545 3 +Abnormal circulating free fatty acid concentration 0.6756278477730644 1.1526167534617522 0.2490677236348273 1.0 0.823825590207127 4 Q16836,O75431 2 +Prominent nasolabial fold 0.5729059231490612 1.1479163634378269 0.2510030923448507 1.0 0.8277174995810376 7 Q8NCH0 1 +Abnormality of the nasolabial region 0.5729059231490612 1.1479163634378269 0.2510030923448507 1.0 0.8277174995810376 7 Q8NCH0 1 +External ear malformation 0.4753246765861849 1.1475707179426664 0.2511458237674548 1.0 0.8277174995810376 14 Q8NCH0,P07437,O75381 3 +Osteolytic defects of the distal phalanges of the hand 0.6740377500958425 1.1457546015068212 0.2518967044317839 1.0 0.8278141229558187 4 O75844,O75431 2 +Abnormality of the posterior pituitary 0.5447734494932822 1.1431402308358605 0.2529803730989877 1.0 0.8293521269742063 8 Q9UHX1 1 +Abnormal autonomic nervous system physiology 0.3832436740380077 1.1416454017561304 0.253601443941623 1.0 0.829853335093365 34 P06280,P07686,P41440,Q709C8,P20700,O43681,Q04656,P04062,O76024,Q9NZJ7,Q9NRG9,P42892,Q15067 13 +Cytochrome c oxidase negative muscle fibers 0.5442488175306333 1.140331143369648 0.254148367677891 1.0 0.8310506809182321 8 O75648,P12235,Q9Y2R0 3 +Delayed menarche 0.590045287463232 1.1398168327828533 0.2543626194093527 1.0 0.8311592780842265 6 O75844,Q9UJS0 2 +Thoracic kyphoscoliosis 0.6120930001082846 1.1375044215328525 0.2553274772660971 1.0 0.8317557610801916 5 O75844 1 +Abnormal pericardium morphology 0.493321563872636 1.1357154427202676 0.2560756754223381 1.0 0.8317557610801916 12 P04062,Q14108,Q9NZ08 3 +Ambiguous genitalia male 0.8207063646693654 1.1355512533424477 0.2561444199820206 1.0 0.8317557610801916 3 O75845 1 +Decreased number of peripheral myelinated nerve fibers 0.4624426776005073 1.1328337811031493 0.2572840623795809 1.0 0.8317557610801916 15 Q9NR77,Q8TB36,O95140,P02545,O15269,Q92734,P07196,Q96RL7 8 +Mitral stenosis 0.8193776066730748 1.1303912421760574 0.2583114027736153 1.0 0.8317557610801916 3 P04062,O75844 2 +Aortic valve calcification 0.8193776066730748 1.1303912421760574 0.2583114027736153 1.0 0.8317557610801916 3 P04062,O75844 2 +Generalized lipodystrophy 0.8193776066730736 1.1303912421760525 0.2583114027736173 1.0 0.8317557610801916 3 O75844,O75431 2 +Angina pectoris 0.8193776066730697 1.1303912421760371 0.2583114027736237 1.0 0.8317557610801916 3 P06280,O75844 2 +Long toe 0.5289995366609059 1.1287698289199974 0.2589949433449752 1.0 0.833248622912951 9 P23786,Q15738,Q9UHX1 3 +Atelectasis 0.5011385211381633 1.1276780920397906 0.2594558931634725 1.0 0.8340828936912892 11 P21964,Q13510 2 +Neoplasm of the small intestine 0.6094172618293998 1.1250289830214628 0.2605767528231004 1.0 0.8356387313242183 5 P21912,P02545 2 +Abnormality of the temporomandibular joint 0.6690947332333455 1.124431652644302 0.2608299503349172 1.0 0.8356387313242183 4 O75844,P02545 2 +Prominent calcaneus 0.8367543296985396 1.1229457645405985 0.261460529329734 1.0 0.8356419575788253 2 Q7RTS9 1 +Impaired visuospatial constructive cognition 0.5409096091266408 1.1224476399739145 0.2616721583605124 1.0 0.8356419575788253 8 Q10713 1 +Mask like facies 0.4608951654254716 1.12235378573861 0.2617120457355129 1.0 0.8356419575788253 15 Q05086,Q9H9S5,Q04656,P04062,O75787 5 +Tetraparesis 0.3797446865538815 1.1188680322302211 0.2631964427037159 1.0 0.8362179020434323 36 Q7RTS9,P17900,P20700,O94905,P21912,Q9UBX3,Q9NZJ7,P35637,P00846 9 +Very long chain fatty acid accumulation 0.667496004441917 1.1175383684339604 0.2637642038832162 1.0 0.8366073869274735 4 O75381 1 +Aplasia hypoplasia of the 5th finger 0.4702317271580331 1.1142001667226935 0.2651933239289337 1.0 0.8387241883222311 14 P13073 1 +Ecchymosis 0.4988532200378525 1.1139975241183495 0.2652802488167025 1.0 0.8387241883222311 11 Q8NCH0,P38435 2 +Secondary microcephaly 0.3490744173886332 1.1111269164222124 0.2665137234971548 1.0 0.8409378038319161 79 Q9Y487,Q5XKP0,Q9BT22,Q86Y39,P50897,Q15043,Q9GZY8,Q9UHX1,Q9H6U8,Q96CU9,O95721,Q9HC21,Q9Y3E5,P00374,Q9BV10 15 +Tongue nodules 0.8329057087877053 1.107255986358504 0.268183267868932 1.0 0.8413723637852877 2 O43924 1 +Alveolar ridge overgrowth 0.8329057087876846 1.1072559863584197 0.2681832678689684 1.0 0.8413723637852877 2 Q15392 1 +Bone pain 0.4181069012188689 1.1063674254782712 0.268567518776396 1.0 0.8413723637852877 20 P04062,Q14108,Q9Y2U8,Q9NZJ7 4 +Multiple prenatal fractures 0.5376045800792426 1.104741185451406 0.2692717518753982 1.0 0.8413723637852877 8 Q32P28,O75718 2 +Retinal arteriolar tortuosity 0.5111635116424873 1.1043102948603656 0.2694585585586078 1.0 0.8413723637852877 10 P00846 1 +Extra axial cerebrospinal fluid accumulation 0.8316228351507379 1.102031993614664 0.2704477627612043 1.0 0.8413723637852877 2 P20700 1 +Rib segmentation abnormalities 0.66382637315618 1.1017227325935002 0.2705822309202839 1.0 0.8413723637852877 4 Q5H8A4,O95202 2 +Abnormality of abdominal situs 0.66382637315618 1.1017227325935002 0.2705822309202839 1.0 0.8413723637852877 4 Q5H8A4,O95202 2 +Hypoplastic pubic rami 0.66382637315618 1.1017227325935002 0.2705822309202839 1.0 0.8413723637852877 4 Q5H8A4,O95202 2 +Mottled pigmentation 0.8118174907625995 1.101069167373973 0.2708665549280451 1.0 0.8413723637852877 3 O75844 1 +Widely spaced incisors 0.6633504492939616 1.0996723072644647 0.2714749247778392 1.0 0.8421225538209863 4 Q99496,Q8WVM7,Q8WXI9 3 +Neck muscle weakness 0.4572366134395142 1.0975624855327877 0.2723955815788317 1.0 0.8432691267892221 15 Q99720,P02545,Q9NZJ7,P35637,Q9BTV4 5 +Abnormality of the upper arm 0.4098526106343289 1.0962197750977596 0.2729826076009016 1.0 0.8438044093900382 23 Q7RTS9,P16435,Q04656,O14979,O00116,Q9BV10,Q9BTV4,P50402 8 +Reduced forced vital capacity 0.661424903722705 1.0913783387852805 0.2751064397749623 1.0 0.8438044093900382 4 Q9BQT8,P06753,Q9H9S5 3 +Abnormality of adrenal physiology 0.3828485603418823 1.0911240162616018 0.2752183164693047 1.0 0.8438044093900382 31 O75381,Q13423,P38571,O95470,P16435 5 +Short long bone 0.3747184113746611 1.090955885732249 0.2752922942804168 1.0 0.8438044093900382 39 Q7RTS9,P98175,Q96HY6,Q9H6U8,Q04656,Q9UHX1,Q02127,P16278,O00116,Q9BV10,Q96L58,Q9H0W5 12 +Chorea 0.3565030789796984 1.0895005182204345 0.2759332264495642 1.0 0.8439769771018982 88 Q99720,Q5XKP0,Q04656,Q9P0J0,Q9NZ01,P35637,Q01105,Q96N66,O95169,P02792,Q9H6K4,P04350,Q96IX5,P00846,P17900,Q9NZJ7,O43819,Q9BPX6,O43681,Q9BWD1 20 +Preaxial polydactyly 0.4762833132758758 1.088814613726705 0.2762356458948138 1.0 0.8443394476052534 13 Q5H8A4,O43924,Q9UHX1 3 +Retinal pigment epithelial mottling 0.8080054700689511 1.0863095344032014 0.2773420701931901 1.0 0.8445198241374623 3 P00846 1 +Acne 0.4942053984815209 1.0861585393356314 0.2774088568710409 1.0 0.8445198241374623 11 P21964,Q92542 2 +Limited hip movement 0.4480644934927154 1.0843134656913416 0.2782258368208103 1.0 0.8452573204564299 16 O94905,O75844,Q7LGA3 3 +Urticaria 0.5207074066710794 1.0827275035573771 0.278929392396317 1.0 0.8452573204564299 9 P51648 1 +Abdominal distention 0.414821418499137 1.080734085752063 0.2798154162331343 1.0 0.8453543354042201 20 Q7RTS9,O43681,P38571,Q96HY6,P04062,O75648,Q9NZJ7,Q9UGP8 8 +Abnormal pyramidal sign 0.3900602507930221 1.0795645826856717 0.2803361201449441 1.0 0.8453543354042201 124 O14773,Q99720,P41440,O75027,Q9H9P8,Q9P0J0,P35637,O75298,Q8NI60,P02792,O75477,P51648,P21912,Q9H6K4,P07196,P00846,Q9UQN3,Q9NR77,Q13217,O75306,P17900,Q9Y4W6,Q15043,O95831,O60313,O94905,P51572,Q9NZJ7,P20700,Q9NZ08,O43681,P04066,O95140,O75787,Q15067,Q6DKK2 36 +Abnormal lumbar spine morphology 0.5200862200900398 1.0792768999926097 0.2804643074085955 1.0 0.8453543354042201 9 O94905,P04062,O75845 3 +Congenital nystagmus 0.4472911902332417 1.0789309771674285 0.2806184983470654 1.0 0.8453543354042201 16 Q7LGA3 1 +Abnormal cry 0.4840372330307764 1.0784801938612871 0.2808195159595417 1.0 0.8453543354042201 12 Q13510 1 +Weak cry 0.5199353297259746 1.078438702029059 0.280838023307701 1.0 0.8453543354042201 9 Q13510 1 +Abnormal conus terminalis morphology 0.5322641883633064 1.0761211088192133 0.2818730962745615 1.0 0.8469105922752039 8 Q5H8A4,O95202,O96028 3 +Progeroid facial appearance 0.5585367249193328 1.0748734647899132 0.2824313835865286 1.0 0.8469444245649533 7 O75844,Q03252,O75431 3 +Thick hair 0.5319688798411368 1.0745382563896115 0.2825815080540583 1.0 0.8469444245649533 8 Q9Y487 1 +Narrow nasal ridge 0.5584529197354319 1.0744472529094116 0.2826222736731667 1.0 0.8469444245649533 7 O75844,O75431 2 +Orofacial dyskinesia 0.5186300178367557 1.071187323701258 0.2840852101876017 1.0 0.8498325460337146 9 P02792,O75569,Q9UQN3,Q9BPX6 4 +Decreased circulating level of specific antibody 0.5313204185356989 1.0710624416572776 0.2841413544242543 1.0 0.8498325460337146 8 Q9H0U3,Q9BV10,P00813 3 +Pulverulent cataract 0.8232841565105977 1.0681531550431456 0.2854514317704415 1.0 0.8509789112065566 2 P08670 1 +Abnormal aortic valve morphology 0.3714007162678606 1.0663490515604443 0.286265883587115 1.0 0.8528531288438969 40 P06280,Q6NUK1,O75844,Q9BUB7,Q9UHX1,P04062,P21964,P37268,Q96L58,Q9Y4P3 10 +Visual field defect 0.3681690189926158 1.063482957411117 0.287562989840268 1.0 0.8548728573462688 43 Q9H061,Q8WWY3,Q9BVA1,O75381,O60313,O95140,P40855,Q9H6K4,P00846,P00403 10 +Postaxial hand polydactyly 0.4519938658177769 1.0620043235009355 0.2882337224372238 1.0 0.8548728573462688 15 Q9UM00,O43924,Q10713,O75845 4 +Generalized muscle weakness 0.3749147732690013 1.0619744977647034 0.2882472627253374 1.0 0.8548728573462688 34 P12235,Q9UHD9,Q9H9S5,Q92804,P10253,O95831,P21912,P35637,Q15165,Q9UQN3 10 +Decreased circulating cortisol level 0.5167558126081137 1.0607746116914023 0.2887923427262664 1.0 0.8554583585197468 9 P16435,Q9NRG9,Q969G3,Q13423 4 +Muscle hypertrophy of the lower extremities 0.5034599673579362 1.059900170801208 0.2891900179530924 1.0 0.8554583585197468 10 Q9NR77,Q14118,P02545,Q9H9S5 4 +Type 1 muscle fiber atrophy 0.5289820674230672 1.0585280658131742 0.2898147624179841 1.0 0.8567543942440212 8 Q9BTV4,P50402,P02545 3 +Pseudobulbar signs 0.4892857587306485 1.0566729629811356 0.2906608684193581 1.0 0.857026396198371 11 O94905,P17900 2 +Head titubation 0.5547721444390149 1.0557267782362614 0.2910930593280429 1.0 0.857026396198371 7 P35637,Q99720 2 +Stiff skin 0.8191148171905294 1.0512671543379106 0.2931359080052018 1.0 0.857026396198371 2 O75844 1 +Epidermal hyperkeratosis 0.8191148171905294 1.0512671543379106 0.2931359080052018 1.0 0.857026396198371 2 O75844 1 +Abnormal shoulder physiology 0.8191148171905294 1.0512671543379106 0.2931359080052018 1.0 0.857026396198371 2 O75844 1 +Prominent umbilicus 0.8191148171905294 1.0512671543379106 0.2931359080052018 1.0 0.857026396198371 2 O75844 1 +Aplasia hypoplasia of the colon 0.8191148171905294 1.0512671543379106 0.2931359080052018 1.0 0.857026396198371 2 O75844 1 +Thickened skin 0.3661270604050187 1.0499259258315825 0.2937521707330328 1.0 0.857026396198371 101 O75381,Q9NWM8,Q04656,P04062,P42167,O15269,P50402,Q96MF7,P06280,P16615,P98194,P51648,P21912,Q9Y2U8,P07437,P00813,O95721,O75844,O75431,O95470,Q15800,P04066,P16278 23 +Muscular dystrophy 0.3985538940868747 1.0478540993088323 0.2947058328287737 1.0 0.8578935871151003 25 O43505,Q15645,Q5JTV8,O14979,P22626,P02545,Q14118,Q9BTV4,P50402 9 +Resting tremor 0.4085214859099551 1.047567804285457 0.2948377774578428 1.0 0.8578935871151003 21 P12235,P02792,P04062,O75787,Q9NZJ7,Q9H6K4,Q9BPX6 7 +Widened cerebral subarachnoid space 0.6512233878660214 1.047494162647927 0.2948717230380371 1.0 0.8578935871151003 4 P00403 1 +Upper limb spasticity 0.5709467644554428 1.0467645322851515 0.2952081922896643 1.0 0.8583285692221969 6 O94905,Q99720 2 +Focal dystonia 0.3954184272155986 1.0462555798048083 0.2954430480765677 1.0 0.8584677428604572 26 Q99720,O75569,P02792,Q9NQZ5,Q9H6U8,Q15043,P22307,P19367,P35637,P04350,Q96L58,Q96RL7 12 +Temporal cortical atrophy 0.6503144334826062 1.0435893725762218 0.2966754119001056 1.0 0.860801602803444 4 O43924,Q9UQN3 2 +Aplasia hypoplasia of the clavicles 0.4862992133963764 1.03876640093791 0.2989133910499972 1.0 0.8634247005633496 11 O75431,Q04656,P02545,Q8NC56,O75844 5 +Abnormal ilium morphology 0.4072479358566337 1.037478425270582 0.2995129453795226 1.0 0.8636463782528855 21 Q7RTS9,O95831,P16278,Q8TAA9,Q96L58 5 +Severe lactic acidosis 0.6487901713427359 1.0370434429723536 0.2997156112899322 1.0 0.8636463782528855 4 Q70HW3 1 +Unusual infection by anatomical site 0.4679692517092396 1.0359292296034857 0.3002351600286659 1.0 0.8636463782528855 13 Q14739,Q9NZ08,Q9BUB7,Q9H9P8,Q8TAA9,P02786 6 +Abnormality of salivation 0.3604604988697605 1.0339158413308265 0.3011755085950043 1.0 0.8652670587982882 47 Q9NR77,P01889,Q05086,Q14739,Q9UHD9,Q9BVA1,Q92804,Q15233,P55795,Q13501,Q03252,O75787,P35670,P15586,P35637,Q15165,Q9UQN3,Q96RL7 18 +Coxa vara 0.4578720017828552 1.0330806971080004 0.3015661358311388 1.0 0.8658474856790233 14 Q9Y487,Q7RTS9,Q96HY6,Q04656,O95831 5 +Adult onset 0.3313522825812612 1.032299778234927 0.3019317049446217 1.0 0.8663552858754741 68 Q14566,P41440,O15118,P04062,P18031,Q9UHD9,P02792,O14979,P21912,P02545,Q9UQN3,Q9H0U3,Q9NZJ7,Q9BTV4,Q9UGP8,P20700,Q8IV08,Q9NQZ5,O76024,P38435 20 +Psychosis 0.3762616868044198 1.0299898098319975 0.3030147891471644 1.0 0.8665492317272284 31 O15118,O76024,Q9UJS0,Q5JRX3,Q9UQN3,P00403,Q6DKK2 7 +Periportal fibrosis 0.7933888290985535 1.0298989427599945 0.3030574470959744 1.0 0.8665492317272284 3 P38571 1 +Personality changes 0.4168622278964416 1.029755424413734 0.3031248305506986 1.0 0.8665492317272284 19 P20700,Q13501,P04062,P35670,Q9UQN3,P00403,Q96RL7 7 +Severe global developmental delay 0.33009364033495 1.0297405943916589 0.3031317939782028 1.0 0.8665492317272284 67 Q7LGA3,Q7RTS9,Q13885,O75381,Q9BT22,Q5H8A4,Q9HC21,Q14118,Q96A33,O00584,Q9BV10,P00846,Q15067 13 +Abnormal placental size 0.6469840307307216 1.0292906360446383 0.303343122196783 1.0 0.8666137361577044 4 O75844 1 +Metatarsus valgus 0.7930702598652405 1.0286730489481453 0.3036333386217711 1.0 0.8669033940376563 3 O43505,Q14118 2 +Microretrognathia 0.4246723599785724 1.027044022235191 0.3043997354406 1.0 0.868551389314975 18 Q9H6U8,Q16625,Q9UHX1,Q8NCH0,Q96MF7 5 +Abnormal cervical spine morphology 0.5882134611446962 1.0262759726016306 0.304761519542974 1.0 0.8690435628706794 5 Q8NCH0 1 +Elevated circulating long chain fatty acid concentration 0.7912658385852789 1.0217325426007473 0.3069075043466571 1.0 0.8727025421502761 3 P23786 1 +Decreased ldl cholesterol concentration 0.7912177082710148 1.0215474883215436 0.3069951221025258 1.0 0.8727025421502761 3 P37268 1 +Abnormal speech prosody 0.5095739002823678 1.0208676279487578 0.3073171582030638 1.0 0.8728308437121836 9 P00846 1 +Abnormality of tibia morphology 0.4455959283747955 1.0185723962619702 0.3084060146299139 1.0 0.8740074155345275 15 Q7RTS9,Q32P28,P16435,O95831,Q9BV10 5 +Progressive microcephaly 0.3637214423809148 1.0177738301798118 0.3087854514595607 1.0 0.8744279823304586 43 Q9Y487,Q9BT22,P50897,Q15043,Q9H6U8,O95721,Q9HC21,Q9BV10 8 +Ventricular escape rhythm 0.5649121512329123 1.0173815554460588 0.3089719528907231 1.0 0.8744279823304586 6 Q9BTV4,P50402 2 +Vascular skin abnormality 0.3773943160076806 1.0140338130714095 0.3105666180980571 1.0 0.8747595306468737 116 Q9Y487,Q6NUK1,Q9NWM8,Q16625,Q04656,P04062,Q96L58,P06280,P98194,Q14108,P51648,P21912,Q8NCH0,P00846,P22830,P35670,P21964,O75844,P10619,P00403,P04066,P16278,P38435 23 +Abnormal sweat gland morphology 0.7891332997638427 1.0135369738052735 0.3108037448463914 1.0 0.8747595306468737 3 O75844 1 +Patchy alopecia 0.7891332997638427 1.0135369738052735 0.3108037448463914 1.0 0.8747595306468737 3 O75844 1 +Generalized hyperpigmentation 0.4819903876702127 1.0129259268205084 0.3110955433524047 1.0 0.8747595306468737 11 P51648 1 +Late onset 0.4950085219759777 1.0111520274163248 0.3119436722791937 1.0 0.8747595306468737 10 P18031,P43304,O76024,P31751 4 +Preaxial hand polydactyly 0.5077662462370214 1.0108231280235624 0.3121010915268087 1.0 0.8747595306468737 9 Q5H8A4,O95202,Q9UHX1 3 +Abnormal circulating igg level 0.454078602898328 1.0081583686937954 0.3133784402416357 1.0 0.8772685482617987 14 P00813,Q15904 2 +Weak voice 0.5192521985268655 1.0063728781999275 0.3142362351824048 1.0 0.8776852575112329 8 P04062,O75787 2 +Disproportionate tall stature 0.3906599371310258 1.005631334722428 0.3145929448956732 1.0 0.8776852575112329 26 Q7LGA3,Q5H8A4,P16435,Q8NCH0,O95202 5 +Decreased adipose tissue 0.4629333037344557 1.0038746242776118 0.3154390492035579 1.0 0.8776852575112329 13 Q6NUK1,O75431,Q03252,Q8NC56,O75844 5 +Progressive spasticity 0.4363130171650362 1.0024464108675886 0.3161280364181791 1.0 0.8784224182336396 16 P17900,O60313 2 +Decreased circulating aldosterone level 0.8069275176395363 1.002135838010079 0.3162779911435867 1.0 0.8784224182336396 2 Q13423 1 +Exercise induced muscle cramps 0.5616380913528183 1.0014487291634655 0.3166099156241788 1.0 0.8788126497162062 6 P23786 1 +Low set posteriorly rotated ears 0.3360486177901097 0.9990612726940252 0.3177650101423572 1.0 0.8814858982257172 75 Q6NUK1,O75381,P98175,Q9UM00,P04062,Q15392,Q02127,O95202,Q96L58,P16435,O96028,P40855,Q10713,Q8NCH0,Q15645,P07437,O43924,P37268,Q9Y4P3,Q5H8A4,Q9H6U8 21 +Progressive cerebellar ataxia 0.3658732868392049 0.9958340040862896 0.3193308054781465 1.0 0.8822106929933048 38 O14773,Q9Y487,Q9P0J0,Q96CU9,O76024,Q7KZN9 6 +Retrocollis 0.7844080846968 0.9954056796482228 0.3195389973580123 1.0 0.8822106929933048 3 P35637,Q99720 2 +Iris coloboma 0.3724517773292997 0.9945649554729104 0.3199478988965045 1.0 0.8822106929933048 31 O43505,Q9H9S5,Q5H8A4,O96028,Q9UHX1,Q14118,Q10713,Q9NX14,Q96EK5,O95202,Q9NRG9 11 +Overtubulated long bones 0.7837698643034499 0.992959827788105 0.3207295319483925 1.0 0.883426898957265 3 O75844 1 +Hypoplasia of the musculature 0.5423683503472032 0.9926458227300416 0.3208825856753958 1.0 0.883426898957265 7 Q9NR77,Q9Y487 2 +Hypoplastic pelvis 0.7836431244118696 0.9924742122257684 0.3209662529864339 1.0 0.883426898957265 3 Q9H0W5 1 +Abnormal peripheral myelination 0.3793622544730732 0.991084803024963 0.3216441729618029 1.0 0.884373785434143 29 Q9NR77,P20700,O43681,O95140,P02545,Q9NZJ7,O15269,P07196,P00846 9 +Eyelid myoclonus 0.5036594909536931 0.9880056932162818 0.3231498599613549 1.0 0.8867788446399166 9 Q01105,Q13510 2 +Bilateral ptosis 0.459429947404084 0.9815709716981114 0.326311254150468 1.0 0.8928770082529744 13 O43819,O60313 2 +Abnormality of the basal ganglia 0.3487837373680061 0.9805340921564354 0.3268225496252173 1.0 0.8931689877929821 89 Q96N66,Q9BPX6,O95169,Q9GZY8,O95831,Q9P0J0,Q96CU9,O60313,P04062,P16278,Q7KZN9,O43819,P23786,P00846,P00403 15 +Vascular neoplasm 0.3643157103915702 0.9804220285495217 0.3268778404325971 1.0 0.8931689877929821 38 Q7LGA3,Q5H8A4,P16435,Q9UHX1,P21912,O95202,P10619 7 +Bilateral sensorineural hearing impairment 0.3978935675323639 0.9800635863515326 0.3270547322032759 1.0 0.8931689877929821 22 Q13217,Q15067,P38159,Q9NZJ7,P35637,P00403 6 +Fat malabsorption 0.5021661211957701 0.9797097468036252 0.3272294135194502 1.0 0.8931689877929821 9 Q96A33,P38571 2 +Distal muscle weakness 0.3239638972461072 0.9785942342201256 0.3277805093027057 1.0 0.8936106402664621 65 Q99720,P41440,Q8TB36,Q9Y3E5,Q04656,O15269,P35637,Q9BQT8,Q13501,P02545,P07196,P00846,Q9NR77,Q9Y4W6,O95831,O94905,P22626,O95140,Q8TD16 19 +Short clavicles 0.4882820723731547 0.9723530179913956 0.330874956389511 1.0 0.8990187104738477 10 O75431,Q04656,P02545,Q8NC56,O75844 5 +Abnormal midbrain morphology 0.4751142877069514 0.9716849113130284 0.3312073254805625 1.0 0.8990187104738477 11 O43924,Q10713 2 +Arthralgia 0.3652172069814432 0.9688740509047056 0.3326080339020087 1.0 0.8991542730528025 34 P06280,Q13510,Q9NZ08,P02792,Q96HY6,Q03252,Q15800,O95140,Q9Y2U8,P35670,Q9Y4P3 11 +Abnormal response to endocrine stimulation test 0.7774061817787612 0.968614718877018 0.3327374567592196 1.0 0.8991542730528025 3 Q13423 1 +Abnormal atrioventricular valve physiology 0.3452545430521111 0.9681697331777988 0.332959608138955 1.0 0.8991542730528025 53 P06280,Q6NUK1,O95169,Q9NZ08,O75431,Q9Y4P3,O00459,Q9H6U8,P04062,P02545,Q9NX14,O43819,O75844,Q96L58,Q15904 15 +Avascular necrosis 0.4001393754341628 0.9659639240766374 0.3340622333473564 1.0 0.8991542730528025 20 P04062,O75844,Q14108,Q9NZ08 4 +Elevated circulating follicle stimulating hormone level 0.6321752665742605 0.9658969805711096 0.3340957333959906 1.0 0.8991542730528025 4 Q96MF7 1 +Abnormal cranial nerve physiology 0.3237652988217947 0.9625309755780794 0.3357829511882355 1.0 0.9014352730795324 66 Q9NR77,P12235,Q13510,O75381,Q9H9S5,Q9NZ08,Q13501,Q9Y3E5,Q15043,Q9UHX1,Q9BUF5,P21912,P40855,P02545,Q9NZJ7,Q96TA2,O43819,P07196 18 +Abnormal larynx morphology 0.3826108426233829 0.9621942714193727 0.335952026190172 1.0 0.9014352730795324 27 Q14739,Q13510,P36543,P16435,Q96HY6,Q9UHX1,P02545,Q9NZJ7,P21964,P25054 10 +Abnormality of limb epiphysis morphology 0.3688895105369392 0.9614082965921265 0.336346914338488 1.0 0.9019298628072376 31 Q5JRA6,Q7LGA3,Q7RTS9,P16435,Q04656,O95831,O95202,Q96L58 8 +Increased muscle lipid content 0.4858223072135345 0.958168170813898 0.3379779644304606 1.0 0.9028214494408096 10 Q9Y4W6,O75648,P23786,Q8NI60 4 +Head tremor 0.4464524060317234 0.9580414917671368 0.3380418365473212 1.0 0.9028214494408096 14 P35637,Q99720,P07196,P20700 4 +Calvarial hyperostosis 0.5727465569218767 0.9544849609401382 0.3398382183030617 1.0 0.905804974891489 5 Q15043 1 +Abnormal atrioventricular valve morphology 0.3636835964273819 0.9541252746398872 0.3400202337908753 1.0 0.905804974891489 34 P36543,O75431,P55795,Q9H6U8,P04062,P02545,Q9NX14,P21964,O75844,Q96L58,O60826,Q9Y4P3 12 +Abnormality of the biliary system 0.3743192285419725 0.9535804657525564 0.3402960476086933 1.0 0.905804974891489 118 Q5XKP0,O75381,Q16134,Q16625,O15118,Q04656,P04062,O95202,Q14108,Q13510,O96028,P40855,Q9UJS0,Q10713,P00374,Q15904,P22830,Q5HYI8,P35670,Q9NZJ7,P21964,O75845,Q9Y4P3,O43681,P38571,Q5H8A4,Q9Y276,P04066,P09601,O75787,Q96A33 31 +Hypertrophic nerve changes 0.7947402180885289 0.9533871091886346 0.3403939703630096 1.0 0.905804974891489 2 Q9NR77 1 +Gastrointestinal obstruction 0.4358802390152631 0.9525757509131454 0.3408050683381454 1.0 0.905804974891489 15 P21912,P42892,Q5HYI8 3 +Decreased cervical spine flexion due to contractures of posterior cervical muscles 0.5342801924810504 0.9515421066063224 0.3413292543154598 1.0 0.905804974891489 7 Q9BTV4,P50402 2 +Retinal vascular tortuosity 0.4451503733741381 0.949484962353614 0.3423740165958382 1.0 0.9061844670951696 14 P21964,O75306,P00846,Q9Y4P3 4 +Rimmed vacuoles 0.4286936291311446 0.9493174713772196 0.3424591702047743 1.0 0.9061844670951696 16 Q13501,O14979,P22626,P02545,Q9BTV4,P50402 6 +Abnormality of skeletal muscle fiber size 0.3960492132679477 0.9486685918928688 0.3427891930115954 1.0 0.9065352448826236 21 Q13501,O95831,O60313,P22626,P02545,Q9BPX6 6 +Small earlobe 0.5506933186483004 0.9482524550991036 0.3430009488704089 1.0 0.9065730318158016 6 P98175,P21964 2 +Recurrent paroxysmal headache 0.483973115706435 0.947506375053552 0.3433808092816335 1.0 0.9066772375679784 10 P00403 1 +Calcinosis 0.5709596222398061 0.946211161582766 0.3440408943244075 1.0 0.9066772375679784 5 O75844,P02545 2 +Posterior fossa cyst 0.7928159076331179 0.9457287358204712 0.3442869618820579 1.0 0.9066772375679784 2 Q9UHX1 1 +Abnormal muscle fiber alpha dystroglycan 0.7928159076331025 0.9457287358204092 0.3442869618820894 1.0 0.9066772375679784 2 Q14118 1 +Calf muscle pseudohypertrophy 0.7928159076331025 0.9457287358204092 0.3442869618820894 1.0 0.9066772375679784 2 Q14118 1 +Congenital muscular dystrophy 0.7928159076330972 0.9457287358203889 0.3442869618820998 1.0 0.9066772375679784 2 P02545 1 +Abnormal morphology of the abdominal musculature 0.4831761469611335 0.9429119723746024 0.3457259305548938 1.0 0.9077370032206612 10 Q8NCH0,Q6NUK1 2 +Toxemia of pregnancy 0.569859051679988 0.9411178331064172 0.3466444777290625 1.0 0.9077370032206612 5 O43772,P02545 2 +Abnormality of the thymus 0.4527433509480483 0.9390036122300044 0.3477288897340727 1.0 0.9080906329744752 13 P00813 1 +Aplasia hypoplasia of the thymus 0.4527433509480483 0.9390036122300044 0.3477288897340727 1.0 0.9080906329744752 13 P00813 1 +Gliosis 0.352672071304921 0.9377106857356742 0.3483931108485225 1.0 0.9093079999463144 46 O95169,P35637,Q9UHD9,P20700,Q16134,Q9H9P8,P04062,Q10713,Q7KZN9,O43819,P00846 11 +Functional motor deficit 0.403364039160334 0.9366812117043196 0.3489225635426809 1.0 0.9101724370593456 153 O14773,Q99720,Q9NWM8,Q9H2D1,P04062,Q9Y2R0,Q15041,Q15907,P35637,P23786,O75298,Q13510,O75477,Q53H12,P21912,P07196,P00846,Q9NR77,Q7RTS9,Q9GZY8,P35670,Q9NZJ7,Q9NX14,O43819,P00403,Q8IUX1,Q9BPX6,Q05086,P20700,P13473,O43681,Q9Y276,Q9HC21,O95140,Q8TD16,Q14118,Q15067 37 +Aplasia hypoplasia involving bones of the lower limbs 0.3389787884554638 0.9328766026114164 0.3508836840936151 1.0 0.91359754682415 83 P13073,Q7LGA3,Q7RTS9,Q13510,O75431,Q5H8A4,P00813,Q9UHX1,O95831,Q04656,Q9NX62,Q9BV10,O95202,Q96L58,Q96A33,O00116 16 +Falls 0.5051445677027334 0.93081773551247 0.3519478538571761 1.0 0.91359754682415 8 Q9BQT8,P21912,O75787,Q96RL7 4 +Supernumerary bones of the axial skeleton 0.5300570127707149 0.9300981998505004 0.3523202427502427 1.0 0.91359754682415 7 Q02127,Q9UHX1 2 +Red green dyschromatopsia 0.7672316528720315 0.9298638576338284 0.3524415781732666 1.0 0.91359754682415 3 Q9H6K4 1 +Abnormality of bladder morphology 0.4598827058956088 0.9293513366491672 0.3527070384358581 1.0 0.91359754682415 12 Q04656,Q9NWM8,Q9H6U8,P16435 4 +Abnormal mitral valve physiology 0.3569414031435112 0.9291805154903962 0.3527955433626639 1.0 0.91359754682415 41 P06280,O95169,Q9NZ08,O75431,O00459,P04062,P02545,Q9NX14,O43819,O75844,Q96L58,Q9Y4P3 12 +Dyslexia 0.492862864992603 0.9280573850352098 0.3533778034174148 1.0 0.9145194450334564 9 Q9H6K4,Q13501,Q9UQN3 3 +Endocarditis 0.5656593607802595 0.921700661102792 0.3566847356441742 1.0 0.91738914360919 5 P04062,Q9NZ08 2 +Psoriasiform dermatitis 0.7641963426371381 0.9183484135224328 0.3584364887148896 1.0 0.9193195082067366 3 P10321,Q15800 2 +Optic nerve hypoplasia 0.4171439341738378 0.9173804042081012 0.3589433375553801 1.0 0.9195590466805792 17 P07196,P37268,Q9NVI7 3 +Hemihypertrophy 0.7854393842206533 0.9164779716377665 0.3594162560449847 1.0 0.9195590466805792 2 P20936 1 +Tongue fasciculations 0.4490439738205283 0.915460615457838 0.3599498692961811 1.0 0.9195590466805792 13 Q9BQT8,Q13510 2 +Absent nipple 0.7851186658114206 0.91521016400586 0.3600813097999413 1.0 0.9195590466805792 2 Q6NUK1 1 +Symptomatic seizures 0.5020077637404087 0.9140406892324958 0.3606954657080266 1.0 0.9195590466805792 8 Q16836,Q13423 2 +Type i transferrin isoform profile 0.5009920047698336 0.9086103828015069 0.3635558239834977 1.0 0.9215023801426426 8 P51571,Q9BT22 2 +Brushfield spots 0.7613535781574405 0.907583445238482 0.3640983440369427 1.0 0.9215023801426426 3 O75381 1 +Generalized amyotrophy 0.3732284908165443 0.9070513175836948 0.364379660332458 1.0 0.9215023801426426 28 Q99567,P13473,Q13501,Q03252,P22626,P51530,Q9Y2U8,P02545,P35637,O43819 10 +Anophthalmia 0.4642331888789791 0.9064547423028064 0.3646952091983566 1.0 0.9215023801426426 11 O43505,Q14118,Q9NX14,Q9H9S5 4 +Abnormal renal cortex morphology 0.33258678647378 0.9064324619741804 0.3647069973250232 1.0 0.9215023801426426 57 P06280,Q14108,Q8NFH4,Q9NZ08,O75431,Q16134,O95470,Q03252,P00813,P21912,P02545,P00846,P00403 13 +Insulin resistant diabetes mellitus 0.5002162472699822 0.904464003174406 0.3657494135052079 1.0 0.9236279193632616 8 O75844,Q96MF7,P02545,O75431 4 +Axial muscle weakness 0.617475479077111 0.9033502712847524 0.3663400237405025 1.0 0.9242339399542486 4 Q8TD16,P02545 2 +Coarse facial features 0.3170028242943137 0.9030204738348708 0.3665150288928884 1.0 0.9242339399542486 64 P06280,P08236,Q7LGA3,Q7RTS9,O95831,P04066,P16278,P15586,P54802,P10619,Q96A33 11 +Atrial arrhythmia 0.4762270108862564 0.9028729361640914 0.3665933357997575 1.0 0.9242339399542486 10 Q9BTV4,P50402,P02545 3 +Macrogyria 0.5245697710151265 0.9022615047544966 0.3669179695524573 1.0 0.9245317783761692 7 O43505,Q15392,Q14118 3 +Female hypogonadism 0.6171314752305067 0.9018920207452642 0.3671142304464727 1.0 0.9245317783761692 4 O75844 1 +Spinal rigidity 0.4374066431946849 0.8986109959564331 0.3688598996544454 1.0 0.9250353172698916 14 O94905,Q9BTV4,P50402,P02545 4 +Skeletal dysplasia 0.3520575824836481 0.8975515666350292 0.3694246700734349 1.0 0.9252747737627603 43 Q7RTS9,O75381,P51648,Q96HY6,Q9H6U8,O95831,P10619,Q9Y2U8,P16278,Q96L58 10 +Hyperorality 0.5596845218661372 0.8941318147500547 0.3712513688379122 1.0 0.9267202810871266 5 Q05086,Q9UQN3 2 +Anorexia 0.382714741355672 0.8936707782009108 0.3714980646885226 1.0 0.9267202810871266 24 P06280,Q14108,Q5HYI8,Q13423,P04062 5 +Abnormality of peripheral nerves 0.3516602126778723 0.8934492291926883 0.3716166494187323 1.0 0.9267202810871266 43 Q99720,Q8TB36,Q9Y3E5,P04792,O15269,P02545,P07196,Q9UBB4,Q9NR77,Q9GZY8,O95831,O95721,Q15120,Q9NZJ7,Q92734,P43243,O43681,O95140,Q96RL7 19 +Scrotal hypoplasia 0.4061438895370122 0.890508338609244 0.3731929929640047 1.0 0.9280546439516182 18 Q9BV10,P07437,P16435,P46977 4 +Diaphyseal thickening 0.7567658038355849 0.8902530302718904 0.3733300355529838 1.0 0.9280546439516182 3 P08236 1 +Loss of ability to walk 0.4360515544099546 0.8897129501027656 0.3736200385835917 1.0 0.9280546439516182 14 P00846 1 +Ambiguous genitalia 0.3862939272839503 0.8867010298619279 0.3752398837496373 1.0 0.9286934265739004 22 Q15645,P16435,Q15392,Q8TAA9,O75845 5 +Drowsiness 0.53748219416653 0.8842355779079907 0.3765690563892856 1.0 0.930979288036193 6 Q5H8A4 1 +Abnormality of t cell physiology 0.435105957766627 0.8835048984763613 0.3769635370721842 1.0 0.9314529594716888 14 P00813 1 +Epiphyseal dysplasia 0.5571258383273534 0.8823477260999358 0.3775887947819418 1.0 0.9317361929465756 5 Q7RTS9 1 +Peroneal muscle atrophy 0.7545717035611148 0.8819840662710013 0.3777854238807014 1.0 0.9317361929465756 3 Q9NR77,P02545 2 +Abnormality of corneal size 0.3530398638482616 0.8817907833033536 0.3778899567123772 1.0 0.9317361929465756 40 O43505,Q9H9S5,Q9NWM8,P07437,Q9Y4P3,Q5H8A4,O96028,Q14118,Q8NCH0,O95202,Q96L58,O75845 12 +Dilatation of the cerebral artery 0.4519532611497272 0.8804317641546524 0.3786254552826378 1.0 0.9323183793580028 12 P38435,Q9H6U8 2 +Mortality aging 0.3562636151671728 0.8800710959765669 0.378820796081073 1.0 0.9323183793580028 105 Q6NUK1,O75381,Q9H9S5,Q16134,Q9BT22,Q15738,Q04656,P04062,P16435,O96000,P02545,P40855,Q96IX5,O60826,Q15904,O43464,P20674,Q14739,O75718,O95721,Q9NX14,Q9NZJ7,O43819,O75844,Q9Y4P3,P07686,Q9NVI7,P38571,O75431,Q9Y276,Q9BUB7,Q9HC21,Q9NWS8,P16278,Q9NPL8,Q15067 36 +Joint hemorrhage 0.776138550352812 0.8798540523681755 0.3789383785410658 1.0 0.9323183793580028 2 P38435 1 +Synostosis of metacarpals metatarsals 0.7535266963026596 0.8780502452942934 0.3799164521460592 1.0 0.933410123690912 3 P16435 1 +Abnormality of the hepatic vasculature 0.4594220349410425 0.8776438419868546 0.3801370291734325 1.0 0.933410123690912 11 Q10713 1 +Abnormal macular morphology 0.3666554421150682 0.8768437964344752 0.3805714870306507 1.0 0.933410123690912 29 Q9NW15,P50897,P51648,Q13510 4 +Abnormal oral frenulum morphology 0.4427876693921457 0.8756707458220788 0.3812090533021908 1.0 0.933410123690912 13 O43924 1 +Scapular winging 0.3754150037508754 0.8752623528234384 0.3814311732961097 1.0 0.933410123690912 26 Q9Y487,O60313,Q8TD16,P07196,Q9BTV4,P50402,Q9H0W5 7 +Abnormality of the cerebrospinal fluid 0.3862809860160352 0.8719655970831378 0.3832271459208354 1.0 0.933410123690912 139 Q6NUK1,Q16625,Q03252,Q9P0J0,P04062,Q15392,Q7KZN9,O95202,P23786,Q96L58,P13073,Q8NI60,O95169,P02792,Q86Y39,P16435,Q96CU9,O96000,P40855,Q10713,P00846,Q9NR77,O00459,O95831,Q9Y6M9,Q8TAA9,Q9NZJ7,Q9NX14,O43819,P21964,P00403,Q8IUX1,O43505,P08236,P20700,O43681,Q9HC21,O95140,Q9NPL8,Q14118,Q96I36 41 +Limb tremor 0.5185143092712614 0.8715847815166886 0.3834349358962363 1.0 0.933410123690912 7 Q9NR77,P04350,Q05086,P20700 4 +Arm dystonia 0.5347490622687993 0.8710271543560418 0.3837393266248219 1.0 0.933410123690912 6 P35637,Q99720 2 +Abnormality of the autonomic nervous system 0.3314460710107659 0.8707885894606654 0.3838695966948717 1.0 0.933410123690912 56 P06280,P07686,P41440,Q709C8,P20700,O43681,Q04656,P04062,O76024,Q10713,Q9NZJ7,O15269,Q96EK5,P21964,Q9NRG9,P42892,Q15067 17 +Constriction of peripheral visual field 0.387956938766422 0.8706286174614299 0.3839569657103796 1.0 0.933410123690912 20 Q9H061,O75381,O60313,P40855,P00846 5 +Coronal craniosynostosis 0.5181856943199125 0.8699215169762325 0.3843432957699795 1.0 0.933410123690912 7 P16435,Q9NX62 2 +Intestinal malrotation 0.3690172768747328 0.8698125239646625 0.3844028661277032 1.0 0.933410123690912 28 P21964,Q02127,Q9Y2U8,Q9BV10,O95202,Q8NCH0 6 +Laryngomalacia 0.4577797840860274 0.8678160022668651 0.3854950683114326 1.0 0.933410123690912 11 P36543,P16435,P02545,Q9NZJ7,P21964 5 +Metaphyseal cupping 0.7729313662604373 0.8672965808550029 0.3857795296090063 1.0 0.933410123690912 2 O95831 1 +Abnormality of the spinal cord 0.3256330121717486 0.8669425922552134 0.385973465019106 1.0 0.933410123690912 75 Q13217,P20700,P21964,P07196,Q5H8A4,Q9Y4P3,Q9UHX1,Q9HC21,Q9Y2U8,P16278,Q10713,Q8TAA9,O95202,Q96L58,O75298,O75845 16 +Progressive external ophthalmoplegia 0.449729880966121 0.8667272972142273 0.3860914451947379 1.0 0.933410123690912 12 P00403 1 +Retinal atrophy 0.3712706172039965 0.8635973104501478 0.3878091421507403 1.0 0.9360840019001307 27 P51648,Q7LGA3 2 +Increased adipose tissue 0.6075177157408406 0.8612552100324223 0.3890974984287378 1.0 0.9363261757111396 4 P02545,O75431 2 +Limb dystonia 0.3865686315738667 0.8597687157994284 0.389916547474622 1.0 0.9372287274638688 20 Q99720,O75569,Q709C8,P02792,Q9Y4W6,Q5BJH7,P35637,P04350,P00387 9 +Infantile spasms 0.3539858075158686 0.8564576986032212 0.3917446614867357 1.0 0.9397731867845548 32 P00846,Q13510 2 +Focal myoclonic seizure 0.5155067641377475 0.8563686160584073 0.3917939184285859 1.0 0.9397731867845548 7 O75503 1 +Abnormal circulating follicle stimulating hormone concentration 0.5152389566323972 0.8550144027329016 0.3925431743733121 1.0 0.940315693588303 7 Q969G3,Q99496,P16435,Q96MF7 4 +Pulmonary insufficiency 0.5306072128029125 0.8510386539493493 0.3947478809815257 1.0 0.942917545050044 6 P00813 1 +Headache 0.3148067576051543 0.8478494816008926 0.3965218019774268 1.0 0.9444187520524094 66 Q9NQZ5,O60313,P04062,P21912,Q8TAA9,P23786,P00846,P00403 8 +Underdeveloped supraorbital ridges 0.4463224747191701 0.8457387143740867 0.3976985208731987 1.0 0.9444187520524094 12 P16435,Q6NUK1,P40855,O75381 4 +Heterotaxy 0.5490128048910253 0.8450817928248433 0.3980651731768865 1.0 0.9444187520524094 5 Q5H8A4,O95202 2 +Orthostatic hypotension 0.4291537194241632 0.8444532600031334 0.398416171274925 1.0 0.9444187520524094 14 P20700,O43681,Q04656,P04062,Q9NZJ7,Q9NRG9 6 +Malabsorption 0.3358049706037456 0.843375246695791 0.399018611287238 1.0 0.9444187520524094 52 P06280,Q14566,O75381,P38571,Q9NZ08,Q9Y3E5,Q04656,P09601,P40855,O76024,Q96A33 11 +Abnormal motor nerve conduction velocity 0.3842833190507955 0.8418970697541248 0.3998455706739847 1.0 0.9444187520524094 20 Q9NR77,Q99720,Q9Y3E5,O95140,P02545,P07196 6 +Prominent nasal bridge 0.3445600157698313 0.8402945955300906 0.4007432308917336 1.0 0.9444187520524094 45 P13073,O95721,Q9Y2U8,O43924,Q10713,P21964,P42892 7 +Hyperextensible skin 0.3992630721010022 0.8398353263052096 0.4010007234089117 1.0 0.9444187520524094 18 Q9NWM8,Q9UHX1,P04062,Q8NCH0,Q96L58 5 +Decreased number of large peripheral myelinated nerve fibers 0.5282390846221021 0.8396264083098947 0.401117887623017 1.0 0.9444187520524094 6 O15269,P07196 2 +Neurogenic bladder 0.4768473353356834 0.8393590640817508 0.4012678480878291 1.0 0.9444187520524094 9 P20936,O76024,Q8TAA9 3 +Glucose intolerance 0.3539171329107436 0.8391764661694305 0.4013702914407291 1.0 0.9444187520524094 106 Q9Y3E5,Q03252,Q06136,P18031,Q8WWY3,Q96MF7,Q5JRA6,Q86Y39,Q96CU9,O96000,P02545,Q13099,Q9Y2U8,P00846,Q13217,P12235,Q5HYI8,O60313,Q9Y6M9,Q8TAA9,Q9NX14,O75844,P00403,Q8IUX1,Q9Y4P3,O75431,O76024,Q9NPL8 28 +Short femur 0.527403264474288 0.835601513913263 0.4033791167923621 1.0 0.9444187520524094 6 Q9BV10,Q9UHX1 2 +Weakness of facial musculature 0.3264901623594414 0.8343437343005216 0.4040873137326088 1.0 0.9444187520524094 57 P12235,Q13510,O75381,Q9H9S5,Q9BQT8,Q13501,Q9Y3E5,Q15043,O60313,Q9UHX1,Q9BUF5,P40855,Q96TA2,O43819,P07196 15 +Distal lower limb muscle weakness 0.3984197277145789 0.8336290531556513 0.404490048612995 1.0 0.9444187520524094 18 Q9NR77,Q8IY17,P19367,O95140,P04792,P02545,P07196,P00846,P53007 9 +Abnormality of prothrombin 0.4183045517623495 0.8332792876702504 0.4046872348419614 1.0 0.9444187520524094 15 Q5XKP0,Q16836,Q9UJS0,Q9BV10,P38435,P49257 6 +Thickened calvaria 0.4868116396112789 0.8329637835531228 0.4048651549522546 1.0 0.9444187520524094 8 P16278 1 +Recurrent pharyngitis 0.7639512508018109 0.8323456310677567 0.4052138810796104 1.0 0.9444187520524094 2 Q9BV10 1 +Periventricular cysts 0.5106627251090435 0.8318935397722899 0.405469038651443 1.0 0.9444187520524094 7 O95202 1 +Vitritis 0.7408872504848276 0.8307161925719853 0.4061339766429981 1.0 0.9444187520524094 3 Q9NX14 1 +Short umbilical cord 0.7408680629578411 0.8306446995977556 0.4061743751499596 1.0 0.9444187520524094 3 O75844 1 +Small placenta 0.7408680629578411 0.8306446995977556 0.4061743751499596 1.0 0.9444187520524094 3 O75844 1 +Bowing of the arm 0.5458516112091483 0.830606099361695 0.406196187967601 1.0 0.9444187520524094 5 Q32P28,Q96L58 2 +Restless legs 0.5256621264124257 0.8272222960292467 0.4081110765657869 1.0 0.9444187520524094 6 P02792,P07196,Q709C8,O95140 4 +Hemivertebrae 0.4630155568660367 0.826920686845803 0.4082820173328305 1.0 0.9444187520524094 10 P16435,Q9UHX1 2 +Abnormal pulmonary thoracic imaging finding 0.3806505493235315 0.8265053386707178 0.4085174908814224 1.0 0.9444187520524094 21 P04062,P21964,Q96L58,Q13510 4 +Anarthria 0.5094992970645967 0.826021741853191 0.4087917585338305 1.0 0.9444187520524094 7 P35637,Q99720 2 +Spastic diplegia 0.37671439015675 0.8258081764887097 0.4089129151224169 1.0 0.9444187520524094 23 Q99720,P51648 2 +Oval face 0.5093025254512861 0.8250289063976942 0.4093551797712138 1.0 0.9444187520524094 7 Q9UHX1 1 +Rib fusion 0.4739381172333084 0.8232933427101238 0.4103411985097978 1.0 0.9444187520524094 9 Q5H8A4,O95202,Q9UM00 3 +Acetabular dysplasia 0.4734108232620869 0.8203833671911972 0.4119975943484579 1.0 0.9444187520524094 9 Q96L58,P16278 2 +Turricephaly 0.4614522836884231 0.8179540113309709 0.4133834476329849 1.0 0.944873643957433 10 P21964,P16435 2 +Neonatal death 0.4250309354918847 0.8174381680948214 0.4136780710856982 1.0 0.944873643957433 14 Q6NUK1,Q9NVI7,P04062,O96000,Q9NX14 5 +Easy fatigability 0.3791736615963061 0.8148011866119635 0.4151861216082069 1.0 0.9462391706378146 21 P12235,Q9NWM8,Q53H12,P21912,Q8IUX1 5 +Abnormal arachnoid mater morphology 0.4722956512704078 0.8142311194146523 0.4155125610990708 1.0 0.9462391706378146 9 Q9UHX1,Q15904 2 +Hypoplastic nipples 0.4409763205177595 0.8128494541058298 0.4163043774759112 1.0 0.9462393014772886 12 P07437,Q9H6U8,Q96A33 3 +Ichthyosis 0.3489313530111605 0.8120706130602574 0.4167511144342897 1.0 0.9462393014772886 34 O75381,O95470,P51648,Q15800,O95721,P04062,P40855,P50402 8 +Bilateral tonic clonic seizure with generalized onset 0.4718329702741867 0.8116794083896599 0.4169756129298583 1.0 0.9462393014772886 9 P04062,Q05086,Q13510 3 +Dolichocephaly 0.352693467652881 0.81043938334882 0.4176876904671966 1.0 0.9462393014772886 31 Q7RTS9,Q969X5,O75381,Q5H8A4,O96028,O95721,P40855,Q4J6C6,O95202,Q9H0W5 10 +Thoracic hypoplasia 0.362291759840079 0.8103479151254236 0.4177402439483937 1.0 0.9462393014772886 28 P16435,Q9UM00,Q96HY6,Q04656,Q9UHX1,P04062,P02545,Q96A33 8 +Somatic sensory dysfunction 0.3438550110254513 0.8086830676723518 0.4186974701420967 1.0 0.9465256054767712 98 O14773,Q04656,O15269,O75298,P06280,Q9H6K4,Q8NCH0,P07196,P00846,Q9NR77,Q13217,O95831,O94905,Q9NZJ7,O43819,P20700,Q9NZ08,Q8IV08,O95140,P54802 20 +Fetal ultrasound soft marker 0.4146144642527909 0.8082858742139001 0.4189260323774606 1.0 0.9465256054767712 15 O75381,P61978,Q9H6U8,P16435,Q13501,P40855,Q9UQN3 7 +Desquamation of skin soon after birth 0.594863978575476 0.808155812101997 0.41900089167372 1.0 0.9465256054767712 4 P00813 1 +Cold induced muscle cramps 0.7343459653831834 0.8064116761157126 0.4200055167140466 1.0 0.9466103717399056 3 P23786 1 +Talipes valgus 0.593966210146094 0.8044072513068052 0.421161814720036 1.0 0.9474294721795 4 Q9HD42 1 +Retinal coloboma 0.4590788600729495 0.8043507885476601 0.4211944135740273 1.0 0.9474294721795 10 Q10713 1 +Proximal muscle weakness in lower limbs 0.3775969062029015 0.8023102349222742 0.4223735234203931 1.0 0.947815260913148 21 O95140,P02545,P35670,P07196,Q9BTV4,P50402 6 +Abnormal thalamic mri signal intensity 0.4699319248513088 0.801200374315564 0.4230156545609824 1.0 0.9482784034351984 9 P02792,Q969G3,Q9GZY8 3 +Plagiocephaly 0.3517020442944863 0.8011968745947969 0.423017680295205 1.0 0.9482784034351984 31 Q01105,Q96L58,Q96A33,Q10713 4 +Posterior polar cataract 0.7556125721616669 0.8001879566114563 0.4236019064690812 1.0 0.9491246230354085 2 P08670 1 +Apnea 0.3271961480825912 0.7967628952061923 0.425588748317798 1.0 0.9503297390695578 82 O43772,Q86Y39,Q9P0J0,Q96CU9,O60313,P04062,P00846,O76024,O43924,Q10713,Q9NZJ7,Q7KZN9,O43819,O75880,P23786,Q96A33 16 +Aplasia hypoplasia of the optic nerve 0.3729321950464053 0.7949533918673989 0.4266406145117751 1.0 0.9517527022466276 23 O95721,P07196,P37268,Q9NVI7 4 +Pili torti 0.7309762940248786 0.7939469247210817 0.4272263303227952 1.0 0.9525964460961402 3 Q9Y276 1 +Abnormal tongue physiology 0.3780838182043983 0.7934597516381846 0.427510009974763 1.0 0.9527662406767656 20 Q13510,Q9BQT8,P10253,O95831,Q9NWS8,P04350 6 +Limb girdle muscle weakness 0.3656323508379952 0.7916009580490682 0.4285933881305908 1.0 0.9535913406329702 26 P12235,O60313,O14979,Q8TD16,P02545,Q14118,Q9NZJ7 7 +Myotonia 0.4789209273850633 0.7910432048882902 0.4289187798752087 1.0 0.9535913406329702 8 Q9BTV4,P50402 2 +Reduced visual acuity 0.3608323478061634 0.7872733885362504 0.4311218442804405 1.0 0.9566362431568404 118 Q96MF7,Q86Y39,P50897,Q96CU9,P21912,O96000,Q10713,Q9H6K4,P00846,Q9H061,P17900,Q15043,O60313,Q9Y6M9,Q9NZJ7,Q8IUX1,O43505,P09622,Q9UHX1,P16278,Q9NPL8,P06865,P68371 23 +Ventricular septal hypertrophy 0.589763811474707 0.7868964888285636 0.4313424631012104 1.0 0.9566634048780952 4 P06280 1 +Abnormal diaphysis morphology 0.3089082852665621 0.7855718690867171 0.432118350369886 1.0 0.9569972728162792 65 Q9NR77,P08236,Q9Y487,Q7LGA3,Q7RTS9,O75431,Q32P28,P16435,Q96HY6,Q04656,P16278,Q9NX62,Q96L58 13 +Upper limb asymmetry 0.7514432328415925 0.7842239955989722 0.4329086875553476 1.0 0.95728089006367 2 P07437 1 +Male sexual dysfunction 0.4432412764050417 0.781022430112015 0.4347893025347662 1.0 0.95728089006367 11 P07686,O43464,Q709C8,P20700,Q969G3,O75298 6 +Abnormal venous morphology 0.3588909726315883 0.7802979467572494 0.4352155210923247 1.0 0.95728089006367 28 Q9Y487,Q6NUK1,P98175,Q04656,P04062,P02545,Q8NC56,P21964 8 +Weight loss 0.3147072826045718 0.7800871127097132 0.4353396014962662 1.0 0.95728089006367 71 Q99720,Q5HYI8,Q9NZ08,P38571,Q13423,Q04656,Q06136,P04062,P21912,P35670,Q9NZJ7,P35637,O75844,P42892 14 +Impaired antigen specific response 0.4547434811474882 0.779538114227998 0.4356627947529896 1.0 0.95728089006367 10 Q9H0U3,Q9BV10,Q13546,P00813 4 +Clonic seizure 0.5155172756617092 0.7785554145735368 0.436241651617075 1.0 0.95728089006367 6 O14936,Q9H936,Q9NZJ7 3 +Generalized limb muscle atrophy 0.4763462084442765 0.7773988718851168 0.4369234778264352 1.0 0.95728089006367 8 O43819 1 +Polydactyly 0.3402688687207938 0.7757751722758822 0.437881745776534 1.0 0.95728089006367 43 P21964,Q5H8A4,P98175,O00459,Q9UM00,Q9UHX1,O43924,Q10713,O95202,Q15067,O75845 11 +Proptosis 0.3266323730041706 0.7750556801915551 0.4383067587191909 1.0 0.95728089006367 54 Q6NUK1,O75431,Q32P28,Q5H8A4,P16435,Q15043,Q9H6U8,O96028,P02545,Q9NX62,Q8NC56,O95202,O75844,Q96L58 14 +Congenital ptosis 0.7479153303399597 0.7707789398568337 0.4408379723200308 1.0 0.95728089006367 2 O75962 1 +Hepatomegaly 0.402976900838451 0.7673219661681072 0.4428901113823467 1.0 0.95728089006367 170 O75381,Q9BT22,Q16625,O15118,Q9Y3E5,P04062,O75880,P23786,P50416,Q14108,O43772,P14927,Q13510,Q86Y39,Q96HY6,Q96CU9,O96000,Q9UJS0,Q10713,P00374,P40855,P00846,Q15904,P20674,P00813,Q9Y6M9,P35670,Q9NZJ7,Q9NX14,Q9UGP8,Q8IUX1,O75845,P08236,P09622,Q9NVI7,P38571,O75431,Q96I36,Q9H6U8,P10253,Q9BUB7,P04066,P09601,Q9HC21,O95140,P16278,Q9NPL8,P54802,P15586,O75787,Q96A33,Q15067 52 +Papillary renal cell carcinoma 0.5129115398723603 0.7661026200675761 0.4436152441475292 1.0 0.95728089006367 6 Q92733 1 +Stroke 0.3478824271262746 0.7656006004299001 0.4439139871070039 1.0 0.95728089006367 31 P06280,O95721,O76024,O75844,P00403 5 +Abnormality of the antitragus 0.7220948845733549 0.7612865355168235 0.4464859409957764 1.0 0.95728089006367 3 Q92643 1 +Scleroderma 0.5305640325394402 0.761021251213012 0.4466443742058406 1.0 0.95728089006367 5 Q9Y2U8,P02545 2 +Irritability 0.3213102929831767 0.760391279011253 0.4470207346543036 1.0 0.95728089006367 79 O43772,Q13510,Q9NZ08,P50897,Q9H6U8,O95831,P21912,Q9HC21,Q9UJS0,Q5BJH7,Q9NZJ7,P37268,P00846 13 +Increased bone mineral density 0.3665963871746023 0.7601400792162227 0.4471708577076541 1.0 0.95728089006367 24 Q14108,Q13501,Q15043,P04062,Q15392,Q9Y2U8,P02545,P54802,Q9Y4P3 9 +Transposition of the great arteries 0.5294536429755765 0.7559974841939122 0.4496507040828643 1.0 0.95728089006367 5 O75844 1 +Aplasia hypoplasia involving the metacarpal bones 0.3614185866667431 0.7556118579195372 0.4498819442820645 1.0 0.95728089006367 26 Q32P28,Q7RTS9,Q96L58,Q9NX62 4 +Decreased pulmonary function 0.5821465836329869 0.7553171971698277 0.4500586825654185 1.0 0.95728089006367 4 P08236,Q969G3 2 +Abnormal cranial nerve morphology 0.3140043832987064 0.7541737770740077 0.4507448813662789 1.0 0.95728089006367 60 O75381,Q9H9S5,Q9Y3E5,Q02978,P51530,Q96TA2,Q13510,Q13501,Q86U42,P21912,P40855,P07196,Q969G3,P12235,Q99496,Q15043,O43819,Q92734,Q9UHX1,P22626,Q9BUF5 21 +Sideroblastic anemia 0.4502325187940381 0.753775463644013 0.4509840595919998 1.0 0.95728089006367 10 O75027 1 +Cerebellar vermis atrophy 0.4311823880604531 0.7527708910137861 0.4515876017390647 1.0 0.9576160182836242 12 Q10713 1 +Abnormality of the upper respiratory tract 0.3373308333474747 0.7511468230416385 0.4525642991707663 1.0 0.9584304425408398 96 P08236,Q9NZJ7,Q7RTS9,Q13510,Q9UHD9,Q92804,Q9BV10,P16435,Q96HY6,P00813,Q9UHX1,P04066,P16278,P15586,P54802,P35637,Q15165,P21964 18 +Facial hypotonia 0.4497618386899741 0.7510908992509504 0.4525979523913179 1.0 0.9584304425408398 10 Q15907 1 +Biparietal narrowing 0.4380280743096579 0.7500236879521076 0.453240438222326 1.0 0.9593484794277082 11 O43924,Q10713 2 +Adipose tissue loss 0.4940184073261069 0.7481864868553434 0.4543476806667819 1.0 0.9598819573413924 7 O75844,Q03252,O75431 3 +Abnormality of ocular smooth pursuit 0.3690434653795394 0.7480517905513926 0.4544289192395201 1.0 0.9598819573413924 22 O14773,Q9NW15,Q10713 3 +Abnormal ossification involving the femoral head and neck 0.5272187422682743 0.7458999096970618 0.4557278798021229 1.0 0.9598819573413924 5 Q7RTS9 1 +Fatigue 0.3210471598857525 0.7442965013153379 0.4566971174309793 1.0 0.9598819573413924 80 P06280,Q5HYI8,Q9UHD9,Q13423,Q70HW3,Q92804,Q9NZ08,Q53H12,Q04656,O60313,P04062,P21912,Q9NZJ7,P35637,Q15165,P50416 16 +Brachycephaly 0.3056945770219538 0.7442698929559824 0.4567132115726835 1.0 0.9598819573413924 65 Q6NUK1,O75431,P07437,P16435,Q9UM00,Q9Y3E5,Q9H6U8,P04062,P04066,Q8NCH0,Q96A33,Q15067 12 +Vertebral compression fracture 0.3991686711332195 0.7439053298768091 0.4569337506832507 1.0 0.9598819573413924 16 Q32P28,P04062,Q14108,Q96HY6 4 +Abnormal spermatogenesis 0.4296800227881955 0.7435794084018861 0.4571309645518806 1.0 0.9598819573413924 12 P04062,Q13423 2 +Abnormal urine alpha ketoglutarate concentration 0.4930671214185842 0.7434244502182069 0.4572247459371723 1.0 0.9598819573413924 7 P21912 1 +Generalized clonic seizure 0.5259409483564891 0.7401351953407901 0.4592179647979844 1.0 0.9614766289119206 5 O14936,Q9H936,Q9NZJ7 3 +Cyanosis 0.3848338945352805 0.7338765783127602 0.4630239630204307 1.0 0.963041751686474 18 O43772,P98175,P04066,P02545,O75844 5 +B lymphocytopenia 0.4677014375574966 0.7317332193838316 0.4643314163740464 1.0 0.963041751686474 8 P00813 1 +Abnormal nerve conduction velocity 0.3387128137227714 0.7315924844375639 0.4644173368087498 1.0 0.963041751686474 39 Q9NR77,Q99720,O43681,Q9Y3E5,Q9GZY8,O95831,O95140,Q9NZJ7,O15269,P07196 10 +Abnormality of cranial sutures 0.3210249835478964 0.7313132278971542 0.4645878525922799 1.0 0.963041751686474 81 Q9Y487,Q6NUK1,O75381,O75431,Q32P28,P16435,Q9H6U8,Q9UM00,O95831,Q04656,Q9Y2U8,P40855,Q9NX62,Q8NCH0,P21964,O75844,Q96L58,O75845 18 +Profound global developmental delay 0.4199458251014032 0.7309928873423489 0.4647834974200551 1.0 0.963041751686474 13 P37268,Q9GZY8,O75381,O60313 4 +Shoulder girdle muscle weakness 0.4196837359392502 0.7293412165539607 0.4657929659728492 1.0 0.9638815590542628 13 O14979,P12235,Q8TD16,Q9NZJ7 4 +Cutaneous photosensitivity 0.3666052542126393 0.7285132078088761 0.4662994865300627 1.0 0.9638815590542628 22 Q14108,P22830,P37268 3 +Prominent antihelix 0.7128649342316234 0.7276628962177402 0.4668199685728726 1.0 0.9641987902644504 3 P98175,O75962 2 +Abnormal protein o linked glycosylation 0.7125458416474069 0.7265066414744552 0.4675282375138294 1.0 0.9646839571750476 3 Q15904 1 +Aplasia of the phalanges of the hand 0.7123900260038749 0.72594218671999 0.4678742129988895 1.0 0.9646839571750476 3 P02545 1 +Abnormal cerebral artery morphology 0.4024018930761713 0.7258211574151113 0.4679484148614312 1.0 0.9646839571750476 15 P38435,Q9H6U8 2 +Loss of voice 0.7121200416926622 0.7249643870940681 0.4684738785951716 1.0 0.9647935958473696 3 Q13510 1 +Equinovarus deformity 0.5039006691078762 0.7232126494538373 0.4695492485301678 1.0 0.9655987503302644 6 Q9NR77,Q969X5 2 +Eeg with generalized slow activity 0.4554314805850527 0.7216052213534283 0.4705372280695763 1.0 0.9655987503302644 9 O75503,P20700,Q9UQN3 3 +Abnormality of the ureter 0.3069013774713727 0.7197949048491119 0.4716512824831227 1.0 0.9655987503302644 68 Q7LGA3,O75844,Q86XL3,P16435,Q9H6U8,Q9UHX1,P21912,O76024,Q8TAA9,P21964,P23786 11 +Sound sensitivity 0.4544759163433616 0.7163843092974782 0.4737540808121703 1.0 0.9665520004916788 9 P17900,Q9GZY8 2 +Aplasia hypoplasia affecting the fundus 0.3567933829248025 0.7161660888060071 0.4738887995991452 1.0 0.9665520004916788 26 O95721,P07196,P37268,Q9NVI7 4 +Large placenta 0.7095841328494965 0.7157951264606192 0.4741178621449053 1.0 0.9665520004916788 3 O75844 1 +Hyperconvex fingernails 0.501910231681097 0.7137779737871139 0.4753644817944589 1.0 0.9669792580173177 6 O95202 1 +Abnormality of the ankles 0.3313501966315411 0.7116780287771142 0.4766641761344239 1.0 0.9669792580173177 46 Q9NW15,Q05086,Q7RTS9,Q15043,O94905,O95140,P02545,Q14118,Q9NZJ7,O75787,O75844,O75298,Q9Y4P3 13 +Upper limb muscle weakness 0.3506907212284469 0.7079494951052375 0.4789766216066249 1.0 0.9669792580173177 28 Q9Y6X9,Q969X5,P37198,Q8N0X7,Q99496,O95140,P02545,Q9BTV4,Q92734,P07196,Q969G3,P50402,P00846 13 +Stillbirth 0.4420167909815629 0.7070250039596719 0.4795509394623578 1.0 0.9669792580173177 10 P16435,Q15738,P04062,P02545,O75844 5 +Lipid accumulation in hepatocytes 0.3068137549422562 0.7054616513343975 0.4805229889246978 1.0 0.9669792580173177 69 Q5XKP0,Q16134,Q9Y3E5,Q03252,O75880,Q7KZN9,P23786,P31751,P50416,Q96MF7,O43772,P02545,Q9UJS0,Q15904,P35670,P38571,O75431,Q16836,Q9Y276,P22626,O75648,Q9NWS8,O75787,Q15067 24 +Cerebral inclusion bodies 0.3993661691387697 0.7054012750897682 0.4805605507255563 1.0 0.9669792580173177 15 P22626,O15118,P04062,O96008 4 +Calvarial skull defect 0.4626682000919709 0.7052636265104463 0.4806461918526505 1.0 0.9669792580173177 8 Q5H8A4,O95202,O96028 3 +Supraventricular arrhythmia 0.3738241308538033 0.7037193078844459 0.4816075937768467 1.0 0.9672166547021448 19 P00846,P50402,P02545,Q9BTV4 4 +Soft skin 0.4519280591568072 0.7024806332059944 0.4823794753302777 1.0 0.9672166547021448 9 Q9NWM8,Q96L58 2 +Enlarged kidney 0.4518420444759599 0.702011695336524 0.482671869880698 1.0 0.9672166547021448 9 P23786 1 +Abnormality of facial musculature 0.3166711511885141 0.7015283609955506 0.4829733417434829 1.0 0.9672166547021448 79 O75381,Q9H9S5,Q9Y3E5,P04062,Q96TA2,Q15907,Q13510,P02792,Q9BQT8,Q13501,P40855,P07196,P12235,Q15043,O60313,O43819,P10253,Q9UHX1,O75787,Q9BUF5 20 +Bilateral cryptorchidism 0.4510296165271947 0.6975839442972239 0.4854374253982092 1.0 0.9672166547021448 9 Q15233,P37268,O43924,P36543 4 +Prominent ear helix 0.7029635803860645 0.6919885093865743 0.4889445450648928 1.0 0.968260022751212 3 O75844 1 +Decreased specific antibody response to protein vaccine 0.7023308853085073 0.6897237036813535 0.4903679565285528 1.0 0.9695431905351362 3 Q9BV10 1 +Emg axonal abnormality 0.7254650416933909 0.6867016603605918 0.49227075046341 1.0 0.9713001327718062 2 Q15120 1 +Shuffling gait 0.4128918860810114 0.6866324097029874 0.4923143996863413 1.0 0.9713001327718062 13 O75844 1 +Abnormal head movements 0.4259277779587849 0.6784306285133653 0.4974986946787609 1.0 0.9716368900180654 11 P35637,Q99720 2 +Facial capillary hemangioma 0.6979164735582133 0.6739735139381463 0.500328152690332 1.0 0.9716368900180654 3 P16435 1 +Increased susceptibility to fractures 0.3161791097233096 0.673066905791728 0.5009047269924414 1.0 0.9716368900180654 55 Q14108,Q32P28,P16435,P04062,Q9Y2U8,P35670,O15269,Q96L58,O75845 9 +Pseudoepiphyses of hand bones 0.5109017588529045 0.6728008668761843 0.5010739861869229 1.0 0.9716368900180654 5 O95202 1 +Tachycardia 0.3516639030142829 0.672515136779488 0.5012558070437481 1.0 0.9716368900180654 26 O43772,P21912,Q9NX14,Q9BTV4,P23786,P42892 6 +Aplasia hypoplasia involving the femoral head and neck 0.4463571431128502 0.6721728054790859 0.5014736913942439 1.0 0.9716368900180654 9 Q96L58,O95831,O75431 3 +Joint swelling 0.4562587470900854 0.6717030459517793 0.5017727618770458 1.0 0.9716368900180654 8 Q13510 1 +Spinal deformities 0.5616782783031584 0.6716444082225986 0.5018100999743753 1.0 0.9716368900180654 4 Q8TB36,Q9H9S5 2 +Pulmonary infiltrates 0.4457862173596644 0.6690744318044891 0.5034479990069518 1.0 0.971966867969162 9 P04062,Q13510 2 +Aplasia hypoplasia of the earlobes 0.4781339646500195 0.6690718882877826 0.5034496214399189 1.0 0.971966867969162 7 P98175,P21964 2 +Abnormality of the elbow 0.3069005067727991 0.6671453369801934 0.5046793033421539 1.0 0.9734512234078546 60 Q7LGA3,Q7RTS9,Q13510,P16435,P37268,O94905,Q96L58,Q9H6K4,P23786,P50402 10 +Mutism 0.3756124942021589 0.6665390510573501 0.5050666116657612 1.0 0.9734512234078546 18 Q13510,P22626,Q9NX14,P35637,Q9UQN3 5 +Motor polyneuropathy 0.40918890477559 0.6634313303625735 0.5070543457381462 1.0 0.9741389669906328 13 O43819,P07196 2 +Arachnodactyly 0.3334066751533846 0.6612119815406498 0.5084763785045323 1.0 0.9741389669906328 32 P21964,Q5H8A4,Q8NCH0,O95202,Q96L58 5 +Bulbous nose 0.3291666616748038 0.6611972283128793 0.508485838527144 1.0 0.9741389669906328 43 O75431,P16435,Q96A33,P21964,P23786,P42892,O75845 7 +Cranial asymmetry 0.4901888242289371 0.6585498408440457 0.5101848816684926 1.0 0.9741389669906328 6 O95202,P40855,O96028 3 +Distal sensory impairment of all modalities 0.5076199815864337 0.6582465658941999 0.510379707184319 1.0 0.9741389669906328 5 O15269 1 +Pseudoepiphyses of the metacarpals 0.5575220773549654 0.6548950977600689 0.5125352967172749 1.0 0.9741389669906328 4 O95202 1 +Hydroureter 0.4077807854043859 0.654626179629562 0.5127084643125488 1.0 0.9741389669906328 13 Q7LGA3 1 +Pigmentary retinopathy 0.321571692267289 0.6544538988559984 0.5128194191074802 1.0 0.9741389669906328 50 Q9P0J0,Q96CU9,P21912,O76024,Q7KZN9,P00846,P00403 7 +Abnormal circulating iga level 0.3999825662019171 0.6543703151935728 0.5128732543931549 1.0 0.9741389669906328 14 P00813,Q15904 2 +Cortical dysplasia 0.3326302568316664 0.6542572905196272 0.5129460569822544 1.0 0.9741389669906328 33 O43505,Q96N66,Q13885,P07437,O95721 5 +Neoplasm of the gallbladder 0.692335690157799 0.6541954737106486 0.5129858773241713 1.0 0.9741389669906328 3 Q9NZJ7 1 +Biliary tract neoplasm 0.692335690157799 0.6541954737106486 0.5129858773241713 1.0 0.9741389669906328 3 Q9NZJ7 1 +Hyperlordosis 0.3202464581885697 0.653772824638807 0.5132581770047793 1.0 0.9741389669906328 51 Q7RTS9,Q9H9S5,P55795,Q96HY6,P22626,P04066,O95140,Q8TD16,P02545,Q14118,P16278,Q9BTV4,P50402,Q9H0W5,Q9Y4P3 15 +Muscle fibrillation 0.3801665880934883 0.6537718641654734 0.5132587958936505 1.0 0.9741389669906328 17 Q9BQT8,Q13510 2 +Heart block 0.3555486462693006 0.6536956717020864 0.5133078923705998 1.0 0.9741389669906328 23 P06280,O43772,Q9BTV4,Q8NC56,P23786,P50402 6 +Neuronal loss in basal ganglia 0.4890656058485788 0.6532898777679187 0.5135694168052676 1.0 0.9741389669906328 6 O43819,O95169 2 +Abnormality of the vertebral endplates 0.4749135321823542 0.653149995046797 0.5136595839281672 1.0 0.9741389669906328 7 Q7RTS9 1 +Abnormal central sensory function 0.5570738946588228 0.6530942958750563 0.5136954893983137 1.0 0.9741389669906328 4 Q969G3,O75787 2 +Glomerular sclerosis 0.3320640173828919 0.6488672620522596 0.5164241769798248 1.0 0.9741389669906328 33 O95470,Q14108,P00403 3 +Abnormal globus pallidus morphology 0.4141062263919014 0.6488104839588203 0.5164608801553601 1.0 0.9741389669906328 12 P02792,O43819,O95169 3 +Prolonged partial thromboplastin time 0.4877441221354429 0.6471092671410394 0.5175612279947188 1.0 0.9741389669906328 6 Q9BV10,P38435 2 +Abnormal brainstem morphology 0.3232173660159306 0.6469567489014332 0.5176599360920524 1.0 0.9741389669906328 90 O95169,Q86Y39,Q96CU9,O96000,Q10713,Q13217,P07437,O95831,O60313,Q9Y6M9,Q9NX14,O43819,Q8IUX1,O43505,Q13885,P20700,Q9BVA1,Q9NPL8,Q14118 19 +Onion bulb formation 0.4514303615125457 0.6465425440800856 0.5179280539573234 1.0 0.9741389669906328 8 Q9NR77,P07196,O95140,P02545 4 +Broad distal phalanx of finger 0.487218623562735 0.6446538836655088 0.5191515077494306 1.0 0.9741389669906328 6 Q7LGA3 1 +Gingival bleeding 0.4200485457306249 0.643869597009813 0.5196599982952994 1.0 0.9741389669906328 11 Q14108 1 +Abnormal middle phalanx morphology of the hand 0.4728044319124861 0.6427471940915086 0.5203881525394127 1.0 0.9741389669906328 7 P02545,Q9UHX1 2 +Hypoglycemic coma 0.4408331519210676 0.6422593653200726 0.5207047932973037 1.0 0.9741389669906328 9 Q16134,Q16836,Q13423 3 +Aphasia 0.330811274346627 0.6417063122149073 0.5210638899878344 1.0 0.9741389669906328 36 Q7LGA3,Q15738,Q9H9P8,P22626,O75648,Q9NX14,O96008,P21964,Q9UQN3,P00403 10 +Delayed puberty 0.3164145400018578 0.6413055223188274 0.5213242020271291 1.0 0.9741389669906328 53 P06280,Q14108,Q9NVI7,P16435,Q15800,P04062,O76024,O75844 8 +Abnormal renal vascular morphology 0.5541319528932942 0.641300186109651 0.521327668333154 1.0 0.9741389669906328 4 P21912 1 +Lissencephaly 0.3084146726743899 0.6408599003658899 0.5216137109373511 1.0 0.9741389669906328 58 O43505,Q9Y487,P20700,Q9BVA1,Q9H9S5,Q16134,Q86XL3,Q16625,Q15738,O00459,O95721,Q15392,Q9HC21,Q9NWS8,Q14118,Q9BV10,P23786,Q9Y320 18 +Absent thumbnail 0.5538597725697363 0.6402113966872093 0.5220351745118004 1.0 0.9742534496681609 4 O14936,Q9H936 2 +Hemiparesis 0.378081573265449 0.6390598703307966 0.5227839845648692 1.0 0.9748583562702332 17 Q9BVA1,P00403,O60313 3 +Aplasia hypoplasia of the hallux 0.3715882695085461 0.637286756845847 0.5239380755554501 1.0 0.9752770577945064 18 Q5H8A4,Q7LGA3,Q9UHX1 3 +Aplasia cutis congenita 0.4185814009403194 0.6352718829636124 0.5252511082086841 1.0 0.9759563970755598 11 Q5H8A4,O95202,Q9H6U8 3 +Delayed eruption of primary teeth 0.711032713277759 0.6341732873785125 0.5259677385463244 1.0 0.9760484375806344 2 Q8NC56 1 +Abnormality of pain sensation 0.3492920358846935 0.6340032207373376 0.5260787202167987 1.0 0.9760484375806344 25 O15269,Q8NCH0,P07196,Q9NR77 4 +Decreased specific antibody response to vaccination 0.5516151180682222 0.6312478317306441 0.5278784914466295 1.0 0.9765317699770026 4 Q9BV10 1 +Abnormality of the tarsal bones 0.336401717112163 0.6308718950984284 0.5281242896692362 1.0 0.9765317699770026 30 Q7RTS9,Q14739,Q969X5,Q99567,P98175,P16435,Q04656,Q9UHX1,Q9UPT5,P02545,O75787,O75844,Q9H0W5 13 +Gaze evoked nystagmus 0.4283883725643493 0.6300878933429767 0.5286370802016278 1.0 0.9765317699770026 10 P41440,Q10713 2 +Spontaneous hematomas 0.7097498396408185 0.6295680076297753 0.528977260586978 1.0 0.9765317699770026 2 Q04656 1 +Abnormality of the 3rd toe 0.7097498396407974 0.6295680076297003 0.5289772605870271 1.0 0.9765317699770026 2 P02545 1 +Limitation of movement at ankles 0.5011084853804544 0.6295347555768879 0.5289990224205632 1.0 0.9765317699770026 5 O75844,Q05086 2 +Pseudoarthrosis 0.5507160327201419 0.627665432045383 0.5302231349771769 1.0 0.9780049870149534 4 O75844 1 +Hyperactive deep tendon reflexes 0.4170160152693587 0.626111165397634 0.5312420291979363 1.0 0.9787216767421912 11 Q9NR77,P21912 2 +Aplasia involving bones of the lower limbs 0.6839859391796457 0.6248984111265485 0.5320377352202423 1.0 0.9793846200465648 3 Q04656 1 +Abnormal forearm bone morphology 0.3498954444416495 0.6225950485667592 0.5335506658111329 1.0 0.981018805305723 24 Q32P28,P16435,Q02127,Q9BV10,Q96L58,Q9H0W5 6 +Prenatal movement abnormality 0.3029991489117255 0.619398377829654 0.5356539495327826 1.0 0.9840685403381372 60 Q70HW3,Q5H8A4,Q9H6U8,Q9UM00,Q9Y3E5,O96028,P04062,Q9HC21,Q96S52,P40855,P02545,Q8TD16,Q7KZN9,O95202,O75844 15 +Fetal akinesia sequence 0.4983061648401005 0.617250133488329 0.5370697527420911 1.0 0.9854514883188858 5 P04062,Q96S52 2 +Irregular menstruation 0.54772407509784 0.6157773319289707 0.5380414902250359 1.0 0.985868202014658 4 P02545 1 +Epiretinal membrane 0.6810037236110861 0.6145242610504625 0.538868946177198 1.0 0.985868202014658 3 P04439 1 +Bull s eye maculopathy 0.7052597819115064 0.6135361473492522 0.5395218891859912 1.0 0.985868202014658 2 Q9UM00 1 +Abnormal pupillary function 0.4972833856556987 0.612777834553776 0.5400232489043133 1.0 0.985868202014658 5 Q9NZJ7 1 +Nasal regurgitation 0.7046183450930352 0.611257063207498 0.5410294113938177 1.0 0.985868202014658 2 Q9BUF5 1 +Subacute progressive viral hepatitis 0.4967530119222375 0.6104610965854788 0.541556406612552 1.0 0.985868202014658 5 P11717 1 +Viral hepatitis 0.4967530119222375 0.6104610965854788 0.541556406612552 1.0 0.985868202014658 5 P11717 1 +Agenesis of corpus callosum 0.3074495542270561 0.6099635142436651 0.541885977071199 1.0 0.985868202014658 77 O43505,Q7LGA3,Q9BVA1,Q5H8A4,Q86XL3,Q9UHX1,Q9HC21,Q14118,Q10713,O95202,P23786,P00403 12 +Cardiac arrest 0.3279768087072887 0.6099411069395829 0.5419008207590976 1.0 0.985868202014658 32 O43772,Q9Y4P3,P04062,Q9NX14,Q8NC56,Q9BTV4,P50402,P50416 8 +Happy demeanor 0.546129839335822 0.6094642317917186 0.5422167741422372 1.0 0.985868202014658 4 Q15907 1 +Megaloblastic anemia 0.4437481270979299 0.6067544538121191 0.5440138784890198 1.0 0.9870050926616452 8 O76024,P00374 2 +Abnormal echocardiogram 0.4956661316211915 0.6057187001625772 0.5447015641393771 1.0 0.9870050926616452 5 Q96RR1,P12235,P54098,P49748 4 +Right ventricular hypertrophy 0.4956661316211912 0.6057187001625756 0.5447015641393782 1.0 0.9870050926616452 5 Q15233,Q7Z494,O95630,Q9H267 4 +Lagopthalmos 0.677187066389104 0.601319162753707 0.5476274286182428 1.0 0.9878811492284292 3 O75844 1 +Femoral bowing 0.4424432005812175 0.6000283452294971 0.5484873450051007 1.0 0.9886554381305132 8 Q32P28,Q7RTS9 2 +Emg myopathic abnormalities 0.3267886151827487 0.5987459104645972 0.549342336780188 1.0 0.9893071340521008 32 P12235,P13473,Q9H9S5,P22626,P02545,P07196,Q9BTV4,P50402 8 +Stenosis of the external auditory canal 0.4636929283386926 0.5980508612161247 0.5498059965481286 1.0 0.9893071340521008 7 O95202,P16435,O96028 3 +Megalocornea 0.4056536699926658 0.5978705143770378 0.5499263354608934 1.0 0.9893071340521008 12 Q9H9S5,Q5H8A4,O96028,O95202,Q9Y4P3 5 +Osteolysis 0.3375185313712188 0.5923366662024978 0.5536251675847823 1.0 0.9920738268468912 28 Q15645,Q14108,O75431,Q04656,P04062,P22626,O75844 7 +Deformed tarsal bones 0.6988454137267612 0.5908746181527867 0.5546044337469445 1.0 0.9926104763650352 2 O75787 1 +Cerebral hemorrhage 0.404384374888227 0.5902579036307121 0.5550177572606732 1.0 0.9926104763650352 12 P23786 1 +Hip contracture 0.3969728991647652 0.5874117913961149 0.5569271764812869 1.0 0.9926104763650352 13 O94905,Q7LGA3 2 +Abnormal urinary electrolyte concentration 0.3500239393069652 0.5854019069915087 0.5582775068104628 1.0 0.9943513392444944 21 P05023,Q9H6U8,P35670,Q13423 4 +Dyspnea 0.3296876320819519 0.5844771197972163 0.558899354479443 1.0 0.9949232014017536 102 Q16134,P51571,P04062,P35637,P23786,Q96L58,P06280,O95169,Q13510,Q9UHD9,P02545,P04350,P00846,Q9UQN3,P12235,Q92804,O95831,Q9NX14,Q9NZJ7,Q15165,O43819,O75844,P10253,Q9UHX1 24 +Coloboma 0.3206978525668888 0.581571533631877 0.5608553218317507 1.0 0.9964961483057208 44 O43505,Q9H9S5,P61978,Q5H8A4,O96028,Q9UHX1,O43924,Q10713,Q9NX14,Q14118,Q96EK5,O95202,Q9NRG9 13 +Motor axonal neuropathy 0.3806489192502976 0.5805240798805924 0.5615612530721228 1.0 0.9969558054346928 15 O15269,P22626,O95831,O60313 4 +Perseveration 0.438250412830203 0.5784859951774615 0.5629360499347995 1.0 0.998274819126168 8 Q15233,Q13501,P35637,Q9UQN3 4 +Anteriorly placed anus 0.4083619053338584 0.5757256941180677 0.5648006052931676 1.0 1.0 11 P16435,Q6NUK1 2 +Abnormalities of placenta or umbilical cord 0.3876689321148343 0.5752890574499797 0.5650958208227661 1.0 1.0 14 O75844,P16278 2 +Delayed closure of the anterior fontanelle 0.3949836415946249 0.5751205218041406 0.5652097897276469 1.0 1.0 13 Q9Y487,Q04656,O75381 3 +Abnormal 2nd finger morphology 0.5371255851594918 0.5741005633678183 0.5658997521510276 1.0 1.0 4 Q9H6K4 1 +Abnormality of dental color 0.6687655937854741 0.5724793034341706 0.5669973033152302 1.0 1.0 3 P16278 1 +Pes cavus 0.3268173454289144 0.5721887899137094 0.5671940812054266 1.0 1.0 100 Q9NR77,Q99720,Q9NW15,Q7LGA3,O15269,P13473,P07196,P05023,O95831,O60313,P04062,Q10713,Q15907,Q9H6K4,O75298 15 +Schistocytosis 0.5361773588301755 0.5704066098410471 0.5684019474903361 1.0 1.0 4 O75845 1 +Emotional lability 0.3057549522803673 0.5702394489302649 0.5685153032687063 1.0 1.0 56 P35637,Q9UHD9,O43681,P02792,Q92804,Q9Y276,Q9P0J0,Q96CU9,Q9NZJ7,Q7KZN9,Q15165,Q9UQN3 12 +Abnormality of the peripheral nervous system 0.325498447105136 0.5675275890815294 0.5703557878595733 1.0 1.0 99 Q99720,Q9Y3E5,Q04656,P04062,O15269,P06280,Q10713,P07196,Q9NR77,Q9GZY8,O95831,O60313,O95721,Q9NZJ7,P21964,P42892,P20700,O43681,Q9NQZ5,O95140,O76024,Q15067 22 +Corneal ulceration 0.48544438095614 0.5614801062255943 0.5744702883559383 1.0 1.0 5 O75844,P02545 2 +Tetraplegia 0.3854848069671829 0.5613676112280568 0.5745469590098726 1.0 1.0 14 P51572,O95831,Q13423 3 +Acantholysis 0.485401860770028 0.561297517455238 0.574594733674993 1.0 1.0 5 P16615 1 +Delayed ability to stand 0.6653961928329928 0.5610600162501309 0.5747566242330135 1.0 1.0 3 P21912 1 +Ectropion of lower eyelids 0.6652834397658414 0.5606791005693019 0.5750163170223461 1.0 1.0 3 Q02127 1 +Limb joint contracture 0.3303229229525492 0.557547647101641 0.5771533143963861 1.0 1.0 105 Q99720,Q7LGA3,Q86XL3,Q9Y3E5,Q15392,Q02127,P35637,P23786,Q96L58,P50402,O75477,P16435,P21912,P07196,Q9NR77,O00459,O60313,O94905,P37268,O75844,P42892,Q9BTV4,Q9HC21,Q8TD16,Q14118 25 +Abnormal tricuspid valve morphology 0.4152538103025744 0.5568871354926539 0.5776045446385933 1.0 1.0 10 P21964,O60826,Q9NX14 3 +Cerebellar atrophy 0.3636641673042461 0.5545321466031976 0.5792147116294744 1.0 1.0 143 O14773,P41440,Q9NW15,Q5XKP0,Q9BT22,Q9Y3E5,P46977,Q9H9P8,Q92643,P13073,Q14108,Q8NI60,Q96CU9,Q96S52,Q10713,Q5BJH7,Q9H6K4,P04350,O75503,Q13217,P12235,P07437,Q15043,Q9GZY8,O60313,P51572,O75845,Q9NVI7,Q9BVA1,Q5H8A4,Q8IV08,Q9H6U8,Q9Y276,Q9Y320,O75787,Q5JRX3,Q6DKK2 37 +Abnormal nipple morphology 0.3043356266365919 0.5537008239012018 0.5797836113252401 1.0 1.0 56 Q7LGA3,Q6NUK1,Q5H8A4,P07437,Q9H6U8,Q02127,Q9BV10,O95202,P23786,Q96A33,Q15067 11 +Abnormality of circulating glucocorticoid level 0.3978570646796347 0.5512821943822402 0.5814402424700607 1.0 1.0 12 P16435,Q9NRG9,Q969G3,Q13423 4 +Temporal pattern 0.4536678658532187 0.5493923700361689 0.5827362091240944 1.0 1.0 7 P04062,O60313 2 +Dry skin 0.3239311567957934 0.5436445514179667 0.5866860957653117 1.0 1.0 31 P51648,P00813,Q04656,P04066,P37268 5 +Apraxia 0.296490461332461 0.5399152803050941 0.5892554595195558 1.0 1.0 60 O14773,Q7LGA3,Q05086,Q9BVA1,P04062,O43924,Q10713,O75787,P35637,Q9UQN3,Q6DKK2 11 +Distal lower limb amyotrophy 0.3816955984993186 0.5373026636553485 0.5910585658199952 1.0 1.0 14 Q9NR77,O95140,P04792,P02545,Q15120,Q8TD16,P07196 7 +Fragile skin 0.4211523213747716 0.5370783479805517 0.5912134962454874 1.0 1.0 9 Q8NCH0 1 +Death in childhood 0.3393571695345966 0.5366870337396301 0.5914838139777716 1.0 1.0 24 P20674,O75431,O95721,Q9NPL8,Q96IX5 5 +Patellar dislocation 0.3512504792049937 0.5353150395694731 0.5924320283378586 1.0 1.0 19 Q9NX62 1 +Absence of pubertal development 0.5268056348167156 0.5342277586506854 0.5931839661893274 1.0 1.0 4 O75844 1 +Aplasia hypoplasia of the scapulae 0.526424009010351 0.5327676831405361 0.5941944071480549 1.0 1.0 4 P16435,Q7RTS9 2 +Preaxial foot polydactyly 0.525978145851441 0.5310631884776275 0.5953749923230172 1.0 1.0 4 O95202 1 +Abnormal thalamic size 0.6564003849855543 0.5309250616297458 0.5954707100692047 1.0 1.0 3 Q9UPT5,Q9H9S5 2 +Adrenal hypoplasia 0.4285309523083886 0.5289896470834284 0.59681263174862 1.0 1.0 8 O75844,Q15738,P02545 3 +Hammertoe 0.3503211642035734 0.5284664621404968 0.5971756187345538 1.0 1.0 19 Q9NR77,Q99720,P07196 3 +Abnormality of the humerus 0.3724407342171565 0.5265007683541141 0.5985403182974003 1.0 1.0 15 Q9BV10,P16435,Q7RTS9,O00116 4 +Progressive 0.3339543871979771 0.52275408602166 0.6011453946682712 1.0 1.0 112 Q99720,Q5XKP0,Q9Y3E5,Q03252,P04062,O75298,O75569,Q709C8,Q13510,Q9UHD9,P02792,O75477,Q13501,Q86U42,Q96D71,P02545,P04350,Q8N1F7,P12235,Q9NR28,Q9Y4W6,Q15043,Q9GZY8,O95831,O60313,Q9Y6M9,O94905,Q9NRG9,P20700,O95470,P15586,P54802 32 +Multifactorial inheritance 0.3930207144263091 0.5226067335901466 0.6012479536897297 1.0 1.0 12 P42892 1 +Myalgia 0.3176308471288898 0.5220038803333785 0.6016676288698246 1.0 1.0 39 P06280,P01889,P12235,P20700,Q14739,Q9NZ08,Q9H9S5,O60313,Q9Y2U8,P02545,P21964,P23786,P25054,Q8IUX1 14 +Myelomeningocele 0.5232277529375499 0.5205811953558283 0.6026585518632874 1.0 1.0 4 Q8TAA9 1 +Absent septum pellucidum 0.3184027259679034 0.5195248625246786 0.6033947797007553 1.0 1.0 34 O43505,Q96N66,P51571,Q9NZ01,Q15392,Q14118,Q9NX14,O95202 8 +Decreased activity of the pyruvate dehydrogenase complex 0.3412282585736245 0.5172493619918593 0.6049820979128118 1.0 1.0 21 Q96CU9,Q9P0J0 2 +Vomiting 0.3137665103912885 0.5163759289904336 0.6055918743503388 1.0 1.0 91 P11117,P06280,P09622,Q13423,P38571,Q86Y39,P22695,P51571,Q96CU9,Q9Y6M9,O96000,Q9NPL8,Q9UJS0,Q9NZJ7,P23786,P00846,P00403,Q8IUX1 18 +Abnormality of thyroid physiology 0.2960539539178036 0.5163252798039605 0.605627242894524 1.0 1.0 73 Q13423,O95470,P00813,O60313,P04066,P21964,P00403 7 +Bradycardia 0.3853110697096457 0.5157762917398824 0.6060106629471942 1.0 1.0 13 O75880,O43772,P02545,Q9BTV4 4 +Aplasia hypoplasia of the tibia 0.474402279670773 0.5144985896720735 0.6069034461612195 1.0 1.0 5 Q9BV10 1 +Diffuse mesangial sclerosis 0.3544007253269078 0.5136315368815033 0.6075096262046855 1.0 1.0 18 P00813 1 +Abnormality of the nasal tip 0.3173668163239456 0.5135287237840005 0.6075815235343467 1.0 1.0 95 Q9Y487,Q7LGA3,O75431,P16435,P23786,Q9UHX1,O95831,O43924,P16278,Q96A33,P21964,O75844,P42892,O75845 14 +Abnormal blood ion concentration 0.292763949753707 0.5129866776422145 0.6079606398407011 1.0 1.0 70 Q9Y487,Q13423,P05023,Q15043,Q9Y276,P21912,P35670,O43819,P21964,Q15904 10 +Hypomimic face 0.3651625746791113 0.5114702755900974 0.6090217970595129 1.0 1.0 16 P02792,P04062,Q15043,O75787 4 +Oligohydramnios 0.3173368697154854 0.511282263251971 0.6091534229045952 1.0 1.0 36 Q7LGA3,Q6NUK1,P16435,Q9H6U8,Q9BUB7,Q9UHX1,P23786,Q96L58 8 +Abnormality of the extraocular muscles 0.6503047802373941 0.5108111128128126 0.6094833269130246 1.0 1.0 3 P43243,Q9BVA1 2 +Focal tonic seizure 0.6751122514432293 0.5097134562648361 0.6102522243479609 1.0 1.0 2 Q9H936 1 +Gastroparesis 0.3963914272906603 0.5068795952930883 0.6122393035103797 1.0 1.0 11 P12235,Q709C8,P61978,Q9BUB7,Q04656 5 +Quadriceps muscle weakness 0.471264519149997 0.501316672898462 0.6161482730793528 1.0 1.0 5 O95140 1 +Abnormal anatomic location of the heart 0.3892786509757532 0.5005510127701427 0.6166871459309216 1.0 1.0 12 Q10713 1 +Lipoatrophy 0.3463745052248584 0.4994773043108647 0.6174431715906108 1.0 1.0 19 Q6NUK1,O75431,Q03252,P04066,P42167 5 +Facial diplegia 0.3888324119312484 0.4979290040866388 0.6185340833836834 1.0 1.0 12 O43819,P12235,Q9H9S5 3 +Abnormal arterial physiology 0.3288556156150136 0.4976769509175517 0.6187117563862978 1.0 1.0 27 P06280,Q14739,Q9NZ08,Q9NWM8,P20936,P02545,O75844,Q9Y4P3 8 +Abnormality of retinal pigmentation 0.2965053463597509 0.4966510974648322 0.619435113304245 1.0 1.0 75 O75381,Q9UG56,P51648,Q9P0J0,Q96CU9,Q6P4Q7,P21912,P00846,P40855,P02545,Q13099,Q9NX14,Q7KZN9,P00403,O76024,Q8WWY3,Q15067 17 +Ventricular tachycardia 0.3675481192953306 0.4945770330424031 0.6208987175170626 1.0 1.0 15 O43772,P23786,Q9NX14 3 +Polycystic kidney dysplasia 0.3625877819139491 0.4942228727590508 0.6211487879413105 1.0 1.0 16 P21964,Q9H6U8,P23786 3 +Foot oligodactyly 0.6686978832584952 0.4885680632371705 0.6251475279337066 1.0 1.0 2 P25054 1 +Myositis 0.4203120771570494 0.4876791537095122 0.6257771197856465 1.0 1.0 8 P01889,P22626,Q9NZ08 3 +Thickened nuchal skin fold 0.3869039117105237 0.4866182357725456 0.6265288980932942 1.0 1.0 12 O75381,P61978,Q9H6U8,P40855,Q9UQN3 5 +Vocal cord paralysis 0.3372225978818641 0.4864658068741886 0.6266369428250611 1.0 1.0 21 Q9NR77,P21912,O95140,P02545,Q9BTV4,P50402 6 +Visual acuity test abnormality 0.513118634781895 0.482556035322673 0.6294110020985539 1.0 1.0 4 Q969G3,P25054 2 +Abnormality of the nasal dorsum 0.3058009166405856 0.4819542505592412 0.6298384461773039 1.0 1.0 50 Q15645,Q6NUK1,O75431,Q9H6U8,O96028,Q04656,O95721,P16278,Q8NC56,O95202,O75844 11 +Abnormality of the fetal cardiovascular system 0.5123952046872817 0.4798664101363294 0.6313223871618179 1.0 1.0 4 P16435 1 +Intestinal hypoplasia 0.5119919694562002 0.4783691219311877 0.6323875069470517 1.0 1.0 4 O75844,P02545 2 +Abnormality of chromosome segregation 0.4654760080473913 0.4772098731896645 0.6332126812495953 1.0 1.0 5 Q15645,Q14739 2 +Agitation 0.3137635258392868 0.4769724016975585 0.6333817741468604 1.0 1.0 36 O43464,Q709C8,Q9UHD9,Q92804,Q13501,P04062,P42892,O96008,P35637,Q15165,Q9UQN3 11 +Abnormality of fibula morphology 0.3849656957693876 0.4752852975410361 0.6345836370318996 1.0 1.0 12 P16435,Q04656,O75431 3 +Craniosynostosis 0.3134708418762423 0.4728830577474848 0.6362966128570551 1.0 1.0 34 Q6NUK1,P16435,Q9Y2U8,Q9NX62,Q8NCH0,P21964,Q96L58 7 +Abnormality of exocrine pancreas physiology 0.3427198497211248 0.4727818225933632 0.6363688438672708 1.0 1.0 19 P09601,Q5HYI8,Q9UHX1,Q15904 4 +Complex febrile seizure 0.6635663887107082 0.4719129601593985 0.636988916984899 1.0 1.0 2 Q8WVX9 1 +Aplasia of the proximal phalanges of the hand 0.6632456703014933 0.4708799165333246 0.6377264906826388 1.0 1.0 2 O75962 1 +Partial absence of thumb 0.6632456703014933 0.4708799165333246 0.6377264906826388 1.0 1.0 2 O75962 1 +Aplasia of metacarpal bones 0.6632456703014933 0.4708799165333246 0.6377264906826388 1.0 1.0 2 O75962 1 +Cupped ear 0.3777695558425034 0.4700624621959889 0.6383103920636315 1.0 1.0 13 Q02127,P42892 2 +Ulnar deviation of finger 0.4167380204443665 0.4698887621425202 0.6384344936021358 1.0 1.0 8 Q96L58 1 +Loss of eyelashes 0.6375568542534107 0.4695997885478782 0.6386409757832039 1.0 1.0 3 O75844 1 +Central nervous system cyst 0.29850964584592 0.4694482647868104 0.6387492562409518 1.0 1.0 55 O43505,Q9Y487,Q15645,Q99567,Q9H9S5,P07437,Q8TAQ2,O96028,Q9UHX1,Q14118,O95202,P23786,P00846,O60826 14 +Aplasia hypoplasia of the ribs 0.3347214492899771 0.4673372841979586 0.6402585852397411 1.0 1.0 21 Q96HY6,Q15738,Q9UHX1,Q8TAA9,Q9BV10,Q96L58,O60826 7 +Agnosia 0.4363730892076104 0.4670038328327452 0.6404971358527383 1.0 1.0 7 O75787,Q9UQN3 2 +Vertebral fusion 0.3835412847325963 0.4669796202401175 0.6405144589526413 1.0 1.0 12 Q8TAA9,Q9UHX1 2 +Developmental regression 0.3452440231194719 0.4651630709337895 0.6418146822358566 1.0 1.0 130 O14773,O75381,Q04656,P06280,P13073,O95169,Q13510,P55795,P21912,P40855,Q96IX5,P00846,O75503,P17900,Q15043,Q9GZY8,O95831,O94905,Q9NZJ7,O43819,Q9Y4P3,Q9NZ08,O95470,Q9NVH6,O76024,P16278,Q15067 27 +Abnormality of hair texture 0.3019960032002874 0.4650374991885836 0.6419046028107429 1.0 1.0 52 Q9Y487,Q6NUK1,Q9NVI7,Q9UM00,Q9Y276,Q04656,P15586,P54802,O75844,Q96A33 10 +Micropenis 0.2883783621970976 0.4626505255357531 0.6436148862943285 1.0 1.0 61 O43505,Q9NVI7,O95470,P16435,P46977,Q02127,Q10713,Q9BV10,P42892 9 +Adducted thumb 0.320150166727159 0.4619317978577464 0.6441302302775493 1.0 1.0 29 Q86XL3,Q04656,Q8NCH0,Q96L58,P42892 5 +Abnormal coronary artery morphology 0.5074594132665637 0.4616336133863396 0.6443440855175186 1.0 1.0 4 P16278 1 +Primary gonadal insufficiency 0.4057945285005088 0.456943899142902 0.6477113695527004 1.0 1.0 9 O76024 1 +Short upper lip 0.5055196356605594 0.4545256403131461 0.649450541579836 1.0 1.0 4 O95202,O96028 2 +Abnormal pupillary light reflex 0.632501904570079 0.4535961165993164 0.6501195490976122 1.0 1.0 3 Q9NZJ7 1 +Slow pupillary light response 0.632501904570079 0.4535961165993164 0.6501195490976122 1.0 1.0 3 Q9NZJ7 1 +Abnormality of the plantar skin of foot 0.3099811313298341 0.4502295917892694 0.6525449010681239 1.0 1.0 40 P16615,Q9Y487,O75431,O95721,P21912,Q9Y2U8,P42167 7 +Decreased circulating gonadotropin concentration 0.5041439400899304 0.4495048078402979 0.6530675405975677 1.0 1.0 4 Q8IY17,Q969G3 2 +Tibial bowing 0.5039128005868831 0.4486628838497324 0.6536748632552929 1.0 1.0 4 Q7RTS9 1 +Recurrent ear infections 0.5038604802276945 0.4484723738566685 0.6538123196637637 1.0 1.0 4 Q9BV10 1 +Hydrocephalus 0.2905818181331404 0.4470749440187427 0.6548209493636279 1.0 1.0 73 O43505,P08236,Q6NUK1,P21964,P16435,O00459,P04062,Q15392,P40855,Q14118,Q10713,Q8TAA9,Q9NX14,O95202,P23786,Q96L58 16 +Bradykinesia 0.3184110501579289 0.4467383635034282 0.6550639789664672 1.0 1.0 29 O43464,O75569,Q709C8,P12235,P02792,Q15043,P04062,O75787,Q96IX5,Q6DKK2 10 +Abnormality of somatosensory evoked potentials 0.5029585873441996 0.4451922568718766 0.6561808219707079 1.0 1.0 4 Q9NQZ5 1 +Abnormal upper limb bone morphology 0.3174991363521821 0.4450102024761345 0.6563123811277694 1.0 1.0 101 Q7LGA3,Q6NUK1,P98175,Q04656,Q02127,O95202,Q96L58,P16435,O96028,Q96S52,Q9NX62,Q7RTS9,O43924,Q9BV10,O75844,Q9Y4P3,P08236,O75431,Q32P28,Q9UHX1,P16278,O00116,Q9H0W5 23 +Flat occiput 0.3663724109000629 0.4413092961718857 0.6589890970575671 1.0 1.0 14 Q05086,P40855,O75381,Q9Y2U8 4 +Deviation of the 2nd finger 0.6284130800618849 0.440798480983929 0.6593588933265675 1.0 1.0 3 Q9H6K4 1 +Abnormal b cell morphology 0.3844975589226624 0.4396794758704738 0.6601692696237369 1.0 1.0 11 P00813 1 +Absent toe 0.3297197256661798 0.4375913070986866 0.6616825738560463 1.0 1.0 22 Q7LGA3,Q5H8A4,O96028,Q9UHX1,P02545,O95202 6 +Abdominal pain 0.2995668486212902 0.4358037571759242 0.6629791176400273 1.0 1.0 83 P06280,Q14566,Q15645,Q14108,Q9UGP8,Q5HYI8,Q9NZ08,Q13423,Q70HW3,Q04656,P04062,P21912,P35637,P23786,P42892,Q9Y4P3 16 +Truncus arteriosus 0.4094366845418619 0.4339052933202622 0.6643572157379176 1.0 1.0 8 P21964 1 +Supernumerary nipple 0.3717107428266206 0.4337476547617454 0.6644716969530853 1.0 1.0 13 Q02127,Q7LGA3 2 +Broad nasal tip 0.3021009086274496 0.4311024960575929 0.6663938458022662 1.0 1.0 49 Q9Y487,Q7LGA3,Q9UHX1,P16278,O43924 5 +Abnormality of the fontanelles or cranial sutures 0.3125645383480233 0.4304201182884968 0.6668900633316039 1.0 1.0 97 Q9Y487,Q6NUK1,O75381,Q9BT22,Q9UM00,Q04656,Q96L58,P16435,Q9Y2U8,P40855,Q9NX62,Q8NCH0,P20674,O95831,P21964,O75844,O75845,O75431,Q32P28,Q9H6U8 20 +Dyscalculia 0.3918780759596303 0.429822551191185 0.6673247272052718 1.0 1.0 10 P35637,P22626,Q13501,Q9UQN3 4 +Small intestinal dysmotility 0.650096215522767 0.42935561888663 0.6676644464541783 1.0 1.0 2 P36551 1 +Abnormal brain positron emission tomography 0.4392706333147343 0.4279918178947193 0.6686570773939289 1.0 1.0 6 Q969G3,Q13501,Q9UQN3 3 +Postaxial polydactyly 0.3279445847961339 0.4239362417146475 0.671612312405315 1.0 1.0 22 O00459,Q9UM00,O43924,Q10713,O75845 5 +Increased circulating antibody level 0.346960681537324 0.4235731439019036 0.6718771447270568 1.0 1.0 17 Q14108,P00813 2 +Osteolysis involving bones of the upper limbs 0.4265352813975036 0.4211914802158862 0.673615265155123 1.0 1.0 7 O75844,O75431 2 +Increased intracranial pressure 0.3411233783626943 0.4200671558904426 0.6744363953083459 1.0 1.0 18 P01889,Q9NZ08,P21912,Q9NZJ7,Q969G3,P25054 6 +Generalized onset motor seizure 0.2967289667497127 0.4198834425235231 0.6745706039712625 1.0 1.0 53 Q01105,Q13510,P04062,P21912,P16278,Q9NZJ7,P00846 7 +Pace of progression 0.372375486915553 0.4167540146435708 0.6768583412318199 1.0 1.0 168 O14773,Q99720,P41440,Q8TB36,Q5XKP0,Q9Y3E5,Q03252,Q9P0J0,Q04656,P04062,P50402,O75298,O75569,Q14108,Q709C8,Q13510,Q9UHD9,P02792,O75477,Q13501,Q86U42,O14979,Q96D71,P02545,Q10713,O00584,P04350,P07196,Q8N1F7,Q9NR77,P12235,Q9NR28,Q9Y4W6,P05023,Q5JTV8,Q15043,Q9GZY8,O95831,O60313,Q9Y6M9,O94905,P49736,Q9NRG9,Q9BTV4,P20700,O95470,Q8IV08,Q9NQZ5,O95140,O75787,P15586,P54802,Q9BUF5 53 +Localized osteoporosis 0.64592687620269 0.4165395569810307 0.6770152279045814 1.0 1.0 2 P57740 1 +Incomitant strabismus 0.3622689262929086 0.4160248511315608 0.6773918185487138 1.0 1.0 14 Q7LGA3 1 +Abnormal sarcomere morphology 0.645606157793473 0.4155609196598005 0.6777313286260087 1.0 1.0 2 Q13501 1 +Abnormal z disc morphology 0.645606157793473 0.4155609196598005 0.6777313286260087 1.0 1.0 2 Q13501 1 +Thin clavicles 0.6201396397034273 0.4153217036440706 0.6779064150807275 1.0 1.0 3 O75844 1 +Hemoglobinuria 0.4944435343743303 0.4145944178362492 0.678438835301642 1.0 1.0 4 Q9H0P0,Q969N2 2 +Progressive inability to walk 0.3271575676589838 0.409980790692347 0.681820038843725 1.0 1.0 21 P21912,P00846 2 +Oligomenorrhea 0.4487961476725552 0.4094260221084169 0.6822270461989057 1.0 1.0 5 Q8N5K1,O00170,Q15031,P31751 4 +Recurrent bacterial infections 0.3279110503557583 0.4091497620325863 0.6824297595831652 1.0 1.0 20 Q8N5M9,P00813 2 +Movement abnormality of the tongue 0.4475393245250228 0.4044282619614439 0.6858978210503099 1.0 1.0 5 P10253 1 +Encephalopathy 0.315063273259563 0.4035378602317732 0.686552588546796 1.0 1.0 102 P04062,Q3ZCQ8,Q7KZN9,P23786,P50416,O43772,O75746,Q86Y39,Q96CU9,O96000,Q9UJS0,Q9Y6M9,Q9NX14,Q9NZJ7,P00403,Q8IUX1,P09622,Q9NVI7,Q9H6U8,Q9Y276,Q9NPL8,Q15067 22 +Astrocytosis 0.3952972595881096 0.4034242224996339 0.6866361703450194 1.0 1.0 9 P00846,Q9UQN3 2 +Bulbar palsy 0.3723821643399554 0.4026476824060037 0.6872074266114685 1.0 1.0 12 P43243,O43681,Q13501,P19367,P35637,P53007 6 +Lower limb hypertonia 0.3950559853516254 0.4022077087844909 0.6875311694166899 1.0 1.0 9 P21912,Q14739 2 +Diabetes insipidus 0.3662235850526401 0.4012153647653901 0.6882615694494776 1.0 1.0 13 P06280 1 +Breech presentation 0.4026959656519211 0.4011512973193425 0.6883087353406925 1.0 1.0 8 O75718,O60313 2 +Conical incisor 0.6407953816549027 0.4010070745049156 0.688414915345885 1.0 1.0 2 Q9Y6K9 1 +Non midline cleft palate 0.6407953816549027 0.4010070745049156 0.688414915345885 1.0 1.0 2 O60716 1 +Bilateral cleft palate 0.6407953816549027 0.4010070745049156 0.688414915345885 1.0 1.0 2 O60716 1 +Infectious encephalitis 0.3861534903570871 0.3995029239192358 0.6895226697202503 1.0 1.0 10 Q9BUB7,Q14739,Q9NZ08,Q9H9P8 4 +Nasal speech 0.3053532122163294 0.3991174930363397 0.6898066333613548 1.0 1.0 32 P21964,Q7LGA3 2 +Recurrent fever 0.3593981706918032 0.3984581774138679 0.6902924810246445 1.0 1.0 14 Q9NR77,Q13510 2 +Impaired tactile sensation 0.4205069962757378 0.3935567673308564 0.6939083050652701 1.0 1.0 7 O15269 1 +Abnormal urine cytology 0.30467138395002 0.3929063969928921 0.6943886166581894 1.0 1.0 38 P06280,Q15645,Q14108,Q9H6U8,Q03252,P04062,P21912,P09601 8 +Short thorax 0.430910274107896 0.3921339137435178 0.6949592705688767 1.0 1.0 6 Q7RTS9 1 +Diplopia 0.3255780341830687 0.391905265946953 0.69512821194695 1.0 1.0 20 O14773,Q9NW15 2 +Abnormal cellular phenotype 0.3851078746035617 0.3897431496096075 0.6967264858390412 1.0 1.0 188 O14773,Q9P0J0,P04062,Q92643,Q9Y2R0,O75880,Q3ZCQ8,Q7KZN9,P23786,P13073,Q14108,O43772,Q13510,Q70HW3,Q86Y39,Q96CU9,P21912,O96000,Q9UJS0,P00846,Q15904,O75503,P20674,Q9GZY8,P00813,Q9Y6M9,Q9UBX3,Q9NZJ7,Q9BV10,P21964,O75844,P00403,Q8IUX1,P09622,P09601,Q9NPL8,P15586 37 +Acanthocytosis 0.4436060143435227 0.3888942124408182 0.6973544036487325 1.0 1.0 5 O14656,Q96RL7,O75845 3 +Odontogenic neoplasm 0.6359846055163687 0.3866930166091666 0.698983486689136 1.0 1.0 2 P25054 1 +Finger swelling 0.6359846055163578 0.3866930166091351 0.6989834866891593 1.0 1.0 2 P28070 1 +Hip dysplasia 0.2992433644914998 0.3825840275549994 0.7020282150156276 1.0 1.0 47 Q7LGA3,Q9NVI7,Q04656,O96028,Q9UHX1,Q8TD16,Q15907,O95202,Q96L58,Q96A33,Q9H0W5 11 +Woolly hair 0.4280741929425683 0.3801322138002115 0.7038472742876338 1.0 1.0 6 Q96A33 1 +Abnormal oral physiology 0.2877794317568695 0.3784871957134924 0.7050687039216965 1.0 1.0 57 Q03252,P35637,Q9UHD9,P55795,Q13501,Q9UQN3,Q9NR77,Q14739,Q92804,P35670,Q15165,P01889,Q05086,Q9BVA1,Q15233,Q6UN15,O75787,P15586,Q96RL7 19 +Neoplasm of the oral cavity 0.3623176350027878 0.3782837432132733 0.7052198207791003 1.0 1.0 13 Q969G3,O43924,P02545,P25054 4 +Ureterocele 0.4839537869062987 0.3778741718825824 0.7055240702126702 1.0 1.0 4 O14936,Q9H936,P09471 3 +Broad chin 0.6327774214240025 0.377286412563319 0.7059607685877594 1.0 1.0 2 P55011 1 +Severe demyelination of the white matter 0.4829858733875677 0.3745429644893033 0.7080003977374585 1.0 1.0 4 Q5H8A4 1 +Arnold chiari malformation 0.3222945880067229 0.3735461805758037 0.7087419813750779 1.0 1.0 21 P16435,Q15043,Q9Y2U8,Q8TAA9,O75845 5 +Moderate global developmental delay 0.3811835071713956 0.3734831935241124 0.7087888515344885 1.0 1.0 10 P21912,O95831 2 +Tissue ischemia 0.322751862860218 0.3711307798385094 0.7105401265516416 1.0 1.0 20 P06280,Q9NZ08,P20936,P02545,O75844,Q9Y4P3 6 +Weakness due to upper motor neuron dysfunction 0.344870429285264 0.3678018921926783 0.7130209580109252 1.0 1.0 139 Q5XKP0,Q9P0J0,P04062,Q15041,Q7KZN9,Q96L58,O75298,P50416,Q13510,Q96CU9,P21912,Q9H6K4,P00846,P17900,Q7RTS9,O95831,O60313,O94905,P51572,Q9UBX3,Q9NZJ7,P00403,Q9BVA1,Q9NZ08,Q13423,Q6DKK2 26 +Abnormality of upper limb epiphysis morphology 0.3428117534496214 0.3642988834604117 0.7156348335434779 1.0 1.0 16 P16435,O95202,Q5JRA6,Q7RTS9 4 +Abnormal duodenum morphology 0.3650563986077413 0.3612116536645164 0.7179412310648763 1.0 1.0 12 Q8NCH0,Q15645 2 +High anterior hairline 0.3205382242850386 0.3604817941252024 0.7184868689560266 1.0 1.0 21 Q5H8A4,O95202,Q7LGA3 3 +Papilloma 0.3784130212368251 0.3591093355878293 0.7195132980085326 1.0 1.0 10 P16615 1 +Abnormality of the parathyroid gland 0.320061779744975 0.3569469876387856 0.7211314925384285 1.0 1.0 21 P21964,P00403 2 +Abnormal talus morphology 0.3191192220918361 0.3567560970064524 0.7212744057870051 1.0 1.0 22 Q969X5,Q99567,P98175,P16435,Q9UHX1,Q9UPT5,P02545,O75844,Q9H0W5 9 +Abnormal myocardium morphology 0.3716648006659023 0.3534714825620589 0.7237350043267528 1.0 1.0 174 Q5XKP0,O75381,Q9BT22,Q9P0J0,P04062,P42167,Q7KZN9,P23786,P50402,P50416,P06280,Q14108,O43772,O95169,Q86Y39,Q53H12,Q96CU9,P21912,O96000,P40855,Q96IX5,P00846,Q9H061,O60313,Q9Y6M9,Q9NX14,O43819,Q9BTV4,P00403,Q8IUX1,Q9Y4P3,P08236,P09622,Q9NVI7,P13473,Q13423,Q9NZ08,Q9Y276,P10253,Q9BUB7,P22626,O76024,P16278,P15586,P54802,Q9NPL8 46 +Abnormal male reproductive system physiology 0.3005226996761552 0.3519498214105038 0.7248758944434428 1.0 1.0 37 Q13423,P16435,Q9H6U8,P04062,O76024,O75298,Q9Y4P3 7 +Delayed ability to walk 0.275947527102142 0.3512825076840776 0.7253764166453893 1.0 1.0 66 Q99720,Q03252,Q3ZCQ8,P55011,P35637,Q9UBB6,Q15907,Q01105,Q96N66,P61978,P21912,Q96D71,Q10713,Q10471,O94905,O75962,Q05086,P20700,Q15233,Q5H8A4,O75648,P48449,Q14118 23 +Abnormal morphology of the radius 0.3449407139941524 0.3505671715958727 0.7259130885840259 1.0 1.0 15 Q32P28,Q9BV10,Q02127,Q96L58 4 +Abnormal sternum morphology 0.3198700332170283 0.3503275902669276 0.7260928615759745 1.0 1.0 112 Q9Y487,Q7LGA3,P98175,Q04656,P04062,Q02127,O95202,P50402,Q96L58,Q13510,P55795,O96028,P21912,Q96S52,P02545,Q8NCH0,Q7RTS9,O75718,P07437,O95831,Q9BTV4,Q9Y4P3,P08236,Q9NVI7,O75431,Q9UHX1,P16278,Q96A33 28 +Contractures involving the joints of the feet 0.3182545289478433 0.3502433085599124 0.7261561070483398 1.0 1.0 22 Q9Y3E5,O60313,O94905,Q8TD16,P02545,Q8IZA0,Q9BTV4,P50402 8 +Abnormality of the skull base 0.2876793258489779 0.3463410682879121 0.7290864081491131 1.0 1.0 55 O43505,Q9Y487,P07437,Q9UHX1,Q9NPL8,Q10713,P23786 7 +Pain in head and neck region 0.4098287273813155 0.3455186062338171 0.7297045248296694 1.0 1.0 7 P20936,Q969G3,Q15043 3 +Diminished movement 0.3192272917388087 0.3454110933698562 0.7297853385026176 1.0 1.0 20 P12235,Q709C8,P13473,O95831,P04062 5 +Vertebral segmentation defect 0.3066642900474953 0.3452985576414212 0.7298699309024816 1.0 1.0 29 Q9H9S5,P61978,P16435,Q9UM00,O96028,Q9UHX1,Q8TAA9,O95202,Q9Y4P3 9 +Maturity onset diabetes of the young 0.6215522771007007 0.3452473205617681 0.7299084465823591 1.0 1.0 2 P61457 1 +Abnormal acetabulum morphology 0.319183820447654 0.3450952405738612 0.7300227713981999 1.0 1.0 20 Q7RTS9,Q96L58,P16278 3 +Posteriorly rotated ears 0.3175777469767639 0.3444848594692471 0.7304816804600625 1.0 1.0 110 Q7LGA3,Q6NUK1,O75381,P98175,Q9UM00,P04062,Q15392,Q02127,O95202,P23786,Q96L58,P16435,O96028,Q96S52,P40855,Q10713,Q8NCH0,Q15645,P07437,O43924,P37268,P42892,Q9Y4P3,O43505,Q5H8A4,Q9H6U8,Q9UHX1,Q14118 28 +Diaphragmatic weakness 0.4736514484161969 0.3429383972376122 0.7316448045997506 1.0 1.0 4 Q9NR77 1 +Abnormal circulating gonadotropin concentration 0.3560603962589264 0.3419759159153426 0.7323690170738018 1.0 1.0 13 P51809,P57740,Q8IY17,Q99496,P16435,Q969G3,Q96MF7 7 +Hypoplastic fingernail 0.3392396907216517 0.3414041051059295 0.7327993851301517 1.0 1.0 16 P51532,P21281,Q14739,P51812,O75431,P48651,Q15149,O14497,Q8TAQ2,Q9Y6K9,Q92785,Q969G3,Q12824,Q96GM5,O60826 15 +Abnormal aldolase level 0.4718533906258048 0.3369621917373051 0.7361454016449502 1.0 1.0 4 O43505,Q14118 2 +Dysphonia 0.2988515141068755 0.3358643001570427 0.7369731991298827 1.0 1.0 35 O75569,P20700,Q13510,P02792,Q15233,Q9Y4P3,P21912,O95140,Q96RL7,P04350,Q6DKK2 11 +Abnormal umbilicus morphology 0.276238020429019 0.3352709541933598 0.737420702227451 1.0 1.0 62 Q96DF8,Q9H936,Q9Y487,Q6NUK1,Q9UJX6,Q15555,Q9NWM8,Q15738,Q04656,Q96S52,P02545,Q8NCH0,Q14739,P07437,P21964,O75844,Q9Y4P3,P08236,Q9BUB7 19 +Abnormal blood potassium concentration 0.3545531159166103 0.3333138277435802 0.7388974025762254 1.0 1.0 13 Q13423 1 +Status epilepticus 0.2910126453332884 0.3330695880397371 0.7390817552123059 1.0 1.0 51 Q01105,Q9Y487,Q13510,P05023,Q03252,Q15392,Q3ZCQ8,Q9NX14,Q9NZJ7,P42892 10 +Cerebellar malformation 0.2838034265629666 0.3325503519576479 0.739473725506901 1.0 1.0 57 O43505,Q9Y487,Q15645,P07437,P16435,Q15043,Q9Y2U8,Q14118,Q8TAA9,P23786,O75845 11 +Abnormality of earlobe 0.3122561304202487 0.3321593371956762 0.7397689464642712 1.0 1.0 25 Q7LGA3,P16435,Q15392,Q9NX14,P21964 5 +Vocal cord paresis 0.4287982405575259 0.3319589885807336 0.7399202269939877 1.0 1.0 5 Q8TB36,O95140 2 +Excessive salivation 0.3028718848643275 0.3317574392572348 0.7400724243147454 1.0 1.0 30 Q9NR77,Q05086,Q9BVA1,P55795,O75787,P35670,P15586 7 +Abnormal periventricular white matter morphology 0.2983604655226857 0.3311268010161788 0.7405487082031721 1.0 1.0 36 O75503,P17900,Q9UHX1,O60313,P51571,Q9NZJ7 6 +Low frustration tolerance 0.3878400976633667 0.3307659975704344 0.740821246521342 1.0 1.0 8 Q9UHX1 1 +Vaginal atresia 0.59093405022468 0.330252136544382 0.7412094553322943 1.0 1.0 3 P16435 1 +Shield chest 0.4160325686393638 0.3301703110852389 0.7412712784490831 1.0 1.0 6 Q7RTS9 1 +Increased circulating gonadotropin level 0.3800914620914974 0.328104234644285 0.7428328522915613 1.0 1.0 9 Q96MF7 1 +Hypoplasia of the brainstem 0.3045975274512128 0.3276983098685106 0.7431397814234375 1.0 1.0 29 O43505,Q13885,Q9UJX6,Q9H9S5,P07437,Q9HD42,Q10713,Q96EK5,Q9Y320 9 +Cerebral visual impairment 0.2728019599981205 0.3244423609012895 0.7456031533059266 1.0 1.0 65 Q01105,Q96CU9,Q5BJH7,P37268,Q96A33,P00403 6 +Azoospermia 0.3632504622264987 0.3235278428321581 0.7462955248113898 1.0 1.0 11 Q13423 1 +Abnormal bleeding 0.3093809458023451 0.3227303944902632 0.7468994313614186 1.0 1.0 103 P11117,Q9Y487,Q14108,Q9NZ08,Q9NWM8,P38435,P23786,Q16625,Q9UHX1,P04062,P21912,O76024,Q9UJS0,P35670,Q8NCH0,P21964,O75844,Q96L58 18 +Tapered finger 0.2969306336204498 0.3190322253054196 0.7497020763524351 1.0 1.0 38 Q15907,Q8NCH0,P42892 3 +Ectopic anus 0.3460631081913181 0.3183478669293768 0.7502210788415162 1.0 1.0 14 P16435,Q6NUK1,Q9NX14 3 +Dermatological manifestations of systemic disorders 0.2812475689580857 0.3176219765608007 0.7507717018711921 1.0 1.0 74 O75381,Q16134,P98175,Q16625,O15118,Q04656,O43772,P40855,P02545,Q9UJS0,P00374,P00387,Q15904,P83436,Q5HYI8,Q14739,P35670,O75844,P38571,P04066,O75648,O75787 22 +Multiple joint contractures 0.3147209961627997 0.3128570738784008 0.7543892516127995 1.0 1.0 20 P41440,Q99567,Q9H9S5,Q15043,Q96S52,P02545,O75844,Q96L58 8 +Abnormal corneal epithelium morphology 0.3301108516901943 0.3117243734810171 0.7552500029399725 1.0 1.0 17 Q14739,Q9NZ08,P51648,P02545,Q96EK5,O75844 6 +Abnormal glomerular mesangium morphology 0.3200644451575263 0.3113882408279407 0.7555054923241857 1.0 1.0 19 P00813 1 +Brain imaging abnormality 0.2950904736518013 0.3112411464503672 0.7556173049663122 1.0 1.0 42 O95169,Q9BT22,Q9BV10,P21912,Q9NZJ7,O43819,Q9UQN3,P00403 8 +Abnormal size of the clitoris 0.3384888840436071 0.3107836410719859 0.7559651068178972 1.0 1.0 15 P16435,P40855,O75381 3 +Vertebral clefting 0.3832608626711221 0.3096278113625872 0.7568440045357134 1.0 1.0 8 Q9BV10 1 +Synostosis involving digits 0.462451861360729 0.3063301785224862 0.7593532638017668 1.0 1.0 4 O60828,Q15233,P48651 3 +Long fingers 0.2852452103384821 0.3062828250943877 0.7593893148531137 1.0 1.0 79 Q9BV10,Q5H8A4,P07437,O95202,P16435,Q9Y3E5,Q9UHX1,Q06136,Q15907,Q8NCH0,P21964,P23786,Q96L58,P42892 14 +Hypopigmented skin patches 0.3101478694581059 0.305386030793522 0.7600721597788525 1.0 1.0 24 P21912,P21964 2 +Radial bowing 0.4618481098043089 0.3043993006876716 0.7608237005004395 1.0 1.0 4 Q32P28 1 +Abnormality of the metaphysis 0.2813478820388413 0.3043433661270695 0.7608663096981938 1.0 1.0 57 Q7RTS9,Q9UG56,Q9H6U8,Q04656,P00813,O95831,Q9Y2U8,P16278,Q96L58,Q96MF7 10 +Deep palmar crease 0.3494290445872174 0.3041275383175781 0.7610307273670904 1.0 1.0 13 Q9Y487,Q6NUK1,O75431,P61978,P98175 5 +Abscess 0.3749311607643275 0.3032241327451715 0.7617190589690457 1.0 1.0 9 Q8TAA9 1 +Slow saccadic eye movements 0.3434626567434916 0.303043348540402 0.7618568264984171 1.0 1.0 14 Q9Y4W6,P04062,Q8IV08,Q96RL7 4 +Prominent eyelashes 0.3817480719794427 0.3027073552762419 0.7621128919331659 1.0 1.0 8 P51532,P20700,Q8TAQ2,Q969G3,Q12824,Q96GM5,Q92785 7 +Asthma 0.3187237934574244 0.3021073176809319 0.7625702542292536 1.0 1.0 19 P00813 1 +Abnormality of the scrotum 0.2936824706295023 0.3014531703303738 0.7630689546748446 1.0 1.0 43 Q7LGA3,Q6NUK1,P07437,P16435,Q9UM00,P46977,Q9BV10 7 +Abnormality of the diencephalon 0.2950367442062984 0.3006562783633038 0.7636766117914282 1.0 1.0 35 O95169,O75306,Q9H9S5,P02792,Q99496,Q9GZY8,Q9UPT5,O43924,O43819,Q969G3,Q9Y4P3 11 +Diaphragmatic eventration 0.5794032723772915 0.2989449482514011 0.7649820506101324 1.0 1.0 3 Q15650,O60568 2 +Short chin 0.3739721815514726 0.2986420222926074 0.7652131986303989 1.0 1.0 9 O75844,Q96S52,P02545 3 +Telangiectasia 0.2948097950733414 0.2985715326724453 0.7652669888205113 1.0 1.0 35 P06280,P10619,P00846 3 +Multifocal epileptiform discharges 0.3048244507104791 0.2979562837484455 0.7657365294787435 1.0 1.0 27 O75503,Q96N66,Q9H936,Q9NZ01,Q9HA77,Q9UBX3,P55011,Q9UBB6 8 +Malnutrition 0.3806256738699433 0.2975934968886858 0.7660134385523927 1.0 1.0 8 P38571 1 +Pharyngitis 0.5786015155407083 0.2968193812079511 0.7666044078768701 1.0 1.0 3 Q9BV10 1 +Abnormal substantia nigra morphology 0.4074343728348651 0.295563960184773 0.7675631001175773 1.0 1.0 6 P02792,P04062 2 +Skin erosion 0.380089468735638 0.2951567430105198 0.7678741447495985 1.0 1.0 8 P98194,O75844 2 +Abnormal circulating igm level 0.3224358847250518 0.2926112030779373 0.7698193495894312 1.0 1.0 18 P00813,Q15904 2 +Microdontia 0.3023163245190199 0.2920100021521783 0.770278976495725 1.0 1.0 28 Q9Y487,Q7LGA3,Q6NUK1,Q9UM00,Q96L58,Q96A33 6 +Nyctalopia 0.3003384714219914 0.2917025331653788 0.7705140722343278 1.0 1.0 29 O75381,Q6P4Q7,O95140,P40855,Q10713,P38435,Q8WWY3 7 +Hypocalcemia 0.3415116455683447 0.2916358952686126 0.7705650274242819 1.0 1.0 14 Q9BV10,P21964,Q4J6C6 3 +Spinal cord compression 0.4171536543513084 0.2890640624527311 0.7725323541762839 1.0 1.0 5 P25054,Q96L58 2 +Abnormal retinal morphology 0.3926396774864917 0.2887702146245675 0.7727572268010268 1.0 1.0 211 O14773,Q9Y487,Q7LGA3,Q5XKP0,Q9NW15,Q15067,O75381,Q9UG56,Q9P0J0,P04062,Q7KZN9,O95202,Q96MF7,O95169,Q13510,P51648,P50897,Q96CU9,P21912,Q10713,Q8NCH0,P00846,O75503,P17900,P07437,O60313,O43924,Q9NZJ7,O43819,P21964,Q9BV10,P10619,P00403,O43505,Q9NZ08,Q5H8A4,Q9Y276,Q9UHX1,O76024,P16278,Q14118,P38435,P06865,P68371 44 +Inappropriate crying 0.3967840409789843 0.2886166552272434 0.7728747486355678 1.0 1.0 7 Q9H6U8,Q9NZJ7 2 +High myopia 0.3718422321790423 0.2885130530638229 0.7729540402217152 1.0 1.0 9 Q9Y487 1 +Abdominal aortic aneurysm 0.5748186232715868 0.2868824917477298 0.774202296828048 1.0 1.0 3 Q96MF7 1 +Craniofacial asymmetry 0.5747199578509213 0.2866253642558501 0.7743991910768429 1.0 1.0 3 O95202 1 +Rieger anomaly 0.5747199578509213 0.2866253642558501 0.7743991910768429 1.0 1.0 3 O95202 1 +Abnormal sternal ossification 0.5747199578509213 0.2866253642558501 0.7743991910768429 1.0 1.0 3 O95202 1 +Chronic axonal neuropathy 0.4561381624410768 0.2863618630073805 0.774600981057207 1.0 1.0 4 O15269,P04792 2 +Migraine 0.3074997839301194 0.2851310855739513 0.7755437152548392 1.0 1.0 24 Q9NQZ5,P00403,O60313 3 +Abnormal circulating dicarboxylic acid concentration 0.2923647070469176 0.2846216047522824 0.7759340573734848 1.0 1.0 42 P41440,Q16134,P22695,P37268,P40855,Q9UJS0,P23786,Q9UGP8,O75845 9 +Severe failure to thrive 0.5735077363088923 0.2834747995796812 0.7768128967537069 1.0 1.0 3 O75844 1 +Misalignment of incisors 0.415504462796978 0.2831333949627878 0.777074583030851 1.0 1.0 5 Q99496,Q8WVM7,Q8WXI9 3 +Dilated fourth ventricle 0.2920756301908577 0.2818085247904537 0.7780903339186931 1.0 1.0 42 O43505,Q9Y487,P23786,Q10713 4 +Slender finger 0.2929081061106955 0.2805310420676496 0.7790701130391169 1.0 1.0 37 P21964,Q5H8A4,Q8NCH0,O95202,Q96L58 5 +Hepatic cysts 0.4034627029611031 0.2799038531162887 0.7795512709803458 1.0 1.0 6 Q9H6U8 1 +Abnormal pulmonary interstitial morphology 0.2921124961820824 0.2792538545257025 0.7800500168356157 1.0 1.0 32 P09601,Q14108,Q13510 3 +Mildly elevated creatine kinase 0.3064189167143076 0.2769071626412372 0.7818513925858954 1.0 1.0 24 Q969X5,Q9H9S5,Q13501,Q16836,O75648,P02545,Q92734,Q9BPX6 8 +Fever 0.2828609435264269 0.2768977688482285 0.7818586058409445 1.0 1.0 79 P06280,Q9NR77,Q13510,P38571,Q9NZ08,P00813,P51572,Q9NZJ7,P23786,P00846,P00403 11 +Abnormality of the helix 0.2924709725650889 0.276518683507508 0.7821497114950338 1.0 1.0 36 O75844,P21964,Q7LGA3 3 +Middle age onset 0.354145829976276 0.2756556290549808 0.78281257848104 1.0 1.0 11 P02792,Q9UQN3,Q9NZJ7 3 +Broad philtrum 0.3541331617883505 0.275589934225402 0.7828630417090725 1.0 1.0 11 P51532,O14497,Q9UM00,Q8TAQ2,Q01082,P11166,Q969G3,Q12824,Q96GM5,Q92785 10 +Hepatoblastoma 0.3617363344051429 0.2748038453491668 0.7834669436405273 1.0 1.0 10 P51532,Q15477,O14497,Q8TAQ2,Q969G3,Q12824,Q96GM5,Q92785,P25054 9 +Pain 0.367859218669919 0.2728812908026463 0.784944468689166 1.0 1.0 178 Q14566,Q8NFH4,Q03252,Q04656,P04062,O15269,P35637,P23786,P50402,P06280,Q14108,Q13510,Q9UHD9,P02792,Q70HW3,O75477,Q96HY6,P21912,Q9Y2U8,P02545,Q9H6K4,Q8N1F7,P00846,Q9UQN3,Q9NR77,Q15645,Q5HYI8,Q92804,Q15043,O60313,Q8TAA9,Q9NZJ7,P35670,Q15165,P21964,O75844,Q9BTV4,P42892,Q9UGP8,Q8IUX1,Q9Y4P3,P20700,Q9NZ08,Q13423,Q9H6U8,Q15800,P22626,O95140 48 +Dermal translucency 0.3685210081753104 0.2728549466925941 0.7849647201081582 1.0 1.0 9 O75844,Q6NUK1,Q96L58 3 +Erectile dysfunction 0.3930115580787729 0.2725651513229887 0.7851875031320041 1.0 1.0 7 P07686,Q969G3,P20700 3 +Impotence 0.3930115580787729 0.2725651513229887 0.7851875031320041 1.0 1.0 7 P07686,Q969G3,P20700 3 +Peptic ulcer 0.3534742584028228 0.2721766451963757 0.7854861986225052 1.0 1.0 11 P04062,O76024 2 +Tics 0.4013303521279495 0.2715847764093571 0.7859413062978906 1.0 1.0 6 Q8WXI9,Q9UHX1 2 +Cone shaped epiphysis 0.338013905633831 0.2713523941755814 0.7861200127673074 1.0 1.0 14 Q7RTS9,O95831,Q96MF7 3 +Skin pit 0.3435724568108727 0.2712951578164282 0.7861640303736264 1.0 1.0 13 P16615,P61978,O96028,Q69YQ0,O95202 5 +Bifid tongue 0.451219512195129 0.271156003420708 0.786271049874187 1.0 1.0 4 P61978,Q9UBM7,Q6DKJ4 3 +Pseudoepiphyses 0.400935374518489 0.2700507588073005 0.7871212038357234 1.0 1.0 6 O95202 1 +Eruption failure 0.3670978824801592 0.2661976206939511 0.7900870153512352 1.0 1.0 9 Q8NC56,O75844,P02545 3 +Oral pharyngeal dysphagia 0.3426119748112608 0.2659674548891632 0.790264273763901 1.0 1.0 13 Q13510 1 +Neuroinflammation 0.4486015999020233 0.2631913483997407 0.7924030987824269 1.0 1.0 4 Q9NZ08 1 +Aplasia hypoplasia of the skin 0.2802285369457671 0.2629525658211684 0.7925871397978432 1.0 1.0 55 O75431,Q9NWM8,Q5H8A4,Q9H6U8,O96028,Q15392,Q9Y2U8,Q9NX14,Q8NCH0,O95202,O75844,Q96L58 12 +Plantar hyperkeratosis 0.2905147231479991 0.262599250967503 0.7928594774459043 1.0 1.0 33 P16615,O75431,O95721,P21912,Q9Y2U8,P42167 6 +Abnormal aortic arch morphology 0.3514561800342714 0.2617676875693236 0.7935005522031102 1.0 1.0 11 P21964,O00459,Q9UHX1 3 +Thoracolumbar kyphosis 0.4092417233508192 0.2609552537535353 0.7941270142331092 1.0 1.0 5 P04062 1 +Reduced tendon reflexes 0.3622810406036191 0.2605788997716736 0.7944172631965554 1.0 1.0 172 Q99720,O75381,Q9BT22,Q9Y3E5,Q04656,P04062,Q15041,O15269,P35637,P50402,P50416,Q13510,Q9BQT8,O75477,O14979,P40855,Q10713,Q9H6K4,P07196,P00846,Q9NR77,Q13217,P05023,O95831,O60313,O95721,Q8TAA9,Q9NZJ7,O43819,Q9BTV4,O43505,O43681,Q5H8A4,P10253,Q9HC21,O95140,Q8TD16,Q14118,O75787,P54802,Q15067 41 +Connective tissue nevi 0.5644402852277535 0.2604169728417768 0.7945421520591263 1.0 1.0 3 Q9Y2U8 1 +Paranoia 0.3982016698779695 0.2594939007577224 0.7952541873875199 1.0 1.0 6 Q96DF8,P50336,P36551,Q8WYQ5,Q96RL7 5 +Pes valgus 0.3509957889858891 0.2594027364694284 0.7953245185638951 1.0 1.0 11 Q5H8A4 1 +Abnormal circulating albumin concentration 0.2899866019704826 0.257881263127743 0.7964985457576255 1.0 1.0 33 O95470,Q5XKP0,Q9UJS0,Q9BT22 4 +Upper limb amyotrophy 0.3170152985450037 0.2568268123507922 0.7973124708791834 1.0 1.0 18 Q9NR77,Q8TB36,P43243,Q9BQT8,Q13501,P04792,Q15120,P07196 8 +Nephrolithiasis 0.3047099439823886 0.2562971547733457 0.7977213940648049 1.0 1.0 23 Q8NCH0,Q9H6U8,P35670,Q9Y4P3 4 +Thick eyebrow 0.2869388743838489 0.2559313583825032 0.7980038403115195 1.0 1.0 47 P08236,Q6NUK1,P98175,Q9UM00,Q8TAQ2,O95831,Q9UHX1,O94905,P04066,O75962,Q9Y2U8,P15586,Q9H0W5 13 +Velopharyngeal insufficiency 0.3971860751612388 0.2555991186395591 0.7982603990247905 1.0 1.0 6 Q9BUF5 1 +Restlessness 0.2896239092395073 0.255153377917172 0.7986046385015568 1.0 1.0 41 Q9UHD9,Q92804,P04062,P42892,Q9UJS0,P35637,Q15165,Q9UQN3 8 +Fibrosarcoma 0.5620789220404281 0.2545618030096532 0.7990615641822396 1.0 1.0 3 P25054,Q13126 2 +Difficulty running 0.3405260556308999 0.2544545895172324 0.7991443820256894 1.0 1.0 13 P07196,O95140,Q8TD16,Q9BPX6 4 +Enlarged cisterna magna 0.3289381578834499 0.2532294814250399 0.8000908858934019 1.0 1.0 15 Q10713 1 +Decreased circulating acth level 0.406741573033712 0.252257268131035 0.8008422153321888 1.0 1.0 5 O00170,Q99496,Q969G3,P10644 4 +Increased sensitivity to ionizing radiation 0.4067415730337121 0.252257268131035 0.8008422153321888 1.0 1.0 5 Q96MG7,Q99496,Q969G3,P49959 4 +Oculomotor nerve palsy 0.406741573033712 0.2522572681310347 0.800842215332189 1.0 1.0 5 O00170,Q99496,Q15149,Q969G3 4 +Heteronymous hemianopia 0.4067415730337119 0.2522572681310344 0.8008422153321892 1.0 1.0 5 O00170,Q99496,Q969G3,P35222 4 +Complete atrioventricular canal defect 0.5608848390681336 0.2516248819805411 0.8013310242657861 1.0 1.0 3 Q9UHX1 1 +Eeg with abnormally slow frequencies 0.3059473894289329 0.2506661867996145 0.8020722051806781 1.0 1.0 20 O75503,Q05086,Q9UQN3 3 +Abnormal cartilage morphology 0.3426002504571906 0.2390895258815694 0.8110361634211527 1.0 1.0 12 Q7LGA3 1 +Abnormal renal insterstitial morphology 0.3318652848045176 0.2362493410533321 0.8132391942920716 1.0 1.0 14 P23786,Q9Y276 2 +Polygenic inheritance 0.438061617458286 0.232058879517052 0.8164922824962728 1.0 1.0 4 O60934,P50454,P35658 3 +Renal agenesis 0.2814186419457568 0.2308758359987294 0.8174112637035265 1.0 1.0 51 Q7LGA3,O95169,Q86XL3,Q9UHX1,O43924,Q8TAA9,O43819 7 +Dysphasia 0.3124668871005076 0.2272881759084803 0.820199666788584 1.0 1.0 18 Q15738,Q9H9P8,Q9NX14,P21964,Q9UQN3 5 +Abnormality of the intrinsic pathway 0.3401365963051809 0.2262156439120923 0.8210337038765763 1.0 1.0 12 Q9Y487,P38435 2 +Pectus excavatum 0.2825752478871796 0.2260814476493896 0.8211380736847307 1.0 1.0 83 Q9Y487,Q7LGA3,O75718,O75431,P98175,P07437,Q9UHX1,Q04656,P04062,P21912,Q02127,P02545,Q96L58,Q8NCH0,Q9BTV4,P50402,Q96A33,Q9Y4P3 18 +Hypoplastic fifth fingernail 0.3816254416961175 0.22533112631578 0.8217216869349584 1.0 1.0 7 P51532,Q8TAQ2,Q969G3,Q12824,Q96GM5,Q92785 6 +Narrow foot 0.5731237973059595 0.2241604903357369 0.8226324253419746 1.0 1.0 2 O60828 1 +Joint dislocation 0.2880924862339559 0.2234744452348057 0.823166269986964 1.0 1.0 89 Q9Y487,O95202,Q9H6U8,Q9Y3E5,Q9UHX1,P51571,Q02127,Q8TD16,Q9NX62,Q8NCH0,P21964,O75844,Q96L58,Q96A33 14 +Glycosuria 0.3507310058654283 0.2215467983875568 0.824666701918001 1.0 1.0 10 Q16134,P35670,Q96MF7 3 +Abnormality of the bladder 0.3159462515572089 0.2177042642819776 0.8276595409534484 1.0 1.0 120 Q99720,Q9NWM8,Q86XL3,Q04656,P04062,Q3ZCQ8,P35637,O75298,P16435,P21912,Q9UJS0,Q8NCH0,P07196,Q9UQN3,Q9NR77,O94905,Q8TAA9,Q9NZJ7,P21964,Q9Y4P3,P20700,O43681,Q9H6U8,Q9UHX1,O76024 25 +Generalized edema 0.4322849807445469 0.2156518550298081 0.8292591322186522 1.0 1.0 4 Q86YH6,Q13724,O43175 3 +Genetic anticipation 0.5450753930061027 0.2142858161970225 0.8303241781879593 1.0 1.0 3 P54886,Q9UBB4 2 +Ovarian cyst 0.32186524525947 0.2117701387179792 0.8322863659947564 1.0 1.0 15 P16435,Q03252,P21912,P02545,Q9Y4P3 5 +Osteomalacia 0.3779988991125155 0.2106934026473838 0.8331265229770464 1.0 1.0 7 P35670 1 +Entropion 0.3547295742185735 0.2097429254304048 0.8338683209743409 1.0 1.0 9 P01889,O75844,P02545 3 +Abnormality of the coagulation cascade 0.2850464571199226 0.2087129134877962 0.8346723586431763 1.0 1.0 39 Q9Y487,Q5XKP0,P36543,Q16836,Q9Y276,P51571,Q6NUQ1,O75648,Q9UJS0,Q4KMQ2,Q9BV10,P38435,P49257 13 +Axonal regeneration 0.4297774376276457 0.2086787357239568 0.8346990411166639 1.0 1.0 4 Q8TB36,P07196 2 +Abnormal patella morphology 0.2960536567974262 0.2072350616585502 0.8358262863693835 1.0 1.0 25 Q9NX62 1 +Juvenile cataract 0.3766627886597336 0.2053525740437734 0.8372966710262157 1.0 1.0 7 Q8NC56 1 +Lower extremity joint dislocation 0.2778594339176701 0.2039885661897909 0.8383624339141296 1.0 1.0 80 Q9Y487,O95202,Q9H6U8,Q9Y3E5,O96028,Q9UHX1,Q04656,Q02127,Q8TD16,Q9NX62,P21964,O75844,Q96L58,Q96A33,Q9H0W5,Q9Y4P3 16 +Distal upper limb amyotrophy 0.3201384596373665 0.2018128525369631 0.8400630334146666 1.0 1.0 15 Q9NR77,Q8TB36,Q9BQT8,Q13501,P07196 5 +Abnormality of adrenal morphology 0.2952390331708298 0.2011240988087996 0.8406015388706924 1.0 1.0 25 P21912,O75844,P38571 3 +Progressive visual field defects 0.5618986529826777 0.200356420534376 0.8412018397708267 1.0 1.0 2 O43395 1 +Epigastric pain 0.561898652982675 0.2003564205343706 0.841201839770831 1.0 1.0 2 Q9NWH9 1 +Splanchnic vein thrombosis 0.561898652982675 0.2003564205343706 0.841201839770831 1.0 1.0 2 Q9NWH9 1 +Portal vein thrombosis 0.561898652982675 0.2003564205343706 0.841201839770831 1.0 1.0 2 Q9NWH9 1 +Abnormality of the carpal bones 0.3123140509341083 0.1992237952012173 0.8420876866146192 1.0 1.0 17 P16435,Q7RTS9,Q96L58 3 +Premature loss of teeth 0.33899246192403 0.199093343254405 0.8421897283106241 1.0 1.0 11 O75844,P53634,Q5JRA6,P02545 4 +Postnatal growth retardation 0.2632860298339611 0.19791613656614 0.843110678750733 1.0 1.0 63 P08236,Q9Y487,P17900,Q7RTS9,O75431,Q9UM00,Q02127,O76024,O95202,Q96L58 10 +Abnormal distal phalanx morphology of finger 0.2811658321480574 0.1977825114078992 0.8432152297540858 1.0 1.0 47 Q7LGA3,O75431,P16435,Q9Y2U8,P38435,O75844,Q96L58 7 +Leukoencephalopathy 0.2858599337499807 0.1965841193065653 0.8441529990650745 1.0 1.0 89 O75503,Q01105,P17900,Q86Y39,Q9UHX1,O60313,Q96CU9,Q9Y6M9,P51571,O96000,Q9NPL8,Q9NZJ7,O00584,O95202,Q8IUX1 15 +Abnormal lower limb bone morphology 0.3506341377265923 0.1965255037768892 0.8441988727400807 1.0 1.0 164 Q9Y487,Q7LGA3,P98175,Q03252,Q04656,P04062,Q15392,O95202,Q96L58,P06280,P13073,Q5JRA6,Q13510,P16435,Q96HY6,O96028,Q96S52,Q10713,Q9NX62,Q8NC56,Q7RTS9,P00813,O95831,O43924,Q9NZJ7,Q9BV10,P21964,O75844,O75845,O43505,P08236,O75431,Q32P28,Q5H8A4,Q9UHX1,P04066,P16278,Q14118,O00116,O75787,Q96A33,Q9H0W5 42 +Vertical supranuclear gaze palsy 0.3245064116222581 0.1952429305646776 0.8452027719725379 1.0 1.0 14 P02792,Q969N2,Q13501,O15118,Q96RL7 5 +Shawl scrotum 0.4246166004280957 0.194616492664171 0.8456931906565912 1.0 1.0 4 Q9UM00 1 +Abnormality of the calf musculature 0.3185883405025498 0.1929320924387028 0.8470121510512794 1.0 1.0 15 Q9NR77,P43243,Q9H9S5,P02545,Q14118,Q9NRG9,Q96RL7 7 +Torsion dystonia 0.4235218759533548 0.1916842598257368 0.8479895361933918 1.0 1.0 4 O14656,P04350 2 +Focal motor status epilepticus 0.556446440025651 0.1893979301044839 0.8497809466479518 1.0 1.0 2 P54098 1 +Centrally nucleated skeletal muscle fibers 0.3555278945097784 0.1883423952334172 0.8506082533916719 1.0 1.0 8 Q9BPX6 1 +Aplasia hypoplasia of the epiglottis 0.5548428479794678 0.1862503810633152 0.8522484167121605 1.0 1.0 2 Q15427 1 +Myopathy 0.2896872124203361 0.1860577083111146 0.8523995066307615 1.0 1.0 94 Q9H9S5,Q9NWM8,Q03252,P42167,P23786,P50402,Q969X5,Q86Y39,Q53H12,Q13501,O14979,P21912,P02545,Q8NCH0,P07196,P00846,P12235,O75306,O60313,Q9BTV4,P00403,Q9Y4P3,P13473,O75648,P22626,Q9NWS8,O76024 27 +Functional abnormality of male internal genitalia 0.2891331220068782 0.1854857808130147 0.8528480320228284 1.0 1.0 28 Q13423,Q9H6U8,P16435,P04062,O76024 5 +Abnormal left ventricular outflow tract morphology 0.3861170546982245 0.1841329605513348 0.8539091497562268 1.0 1.0 5 Q9H6U8 1 +Abnormally large globe 0.3422255049630772 0.1818818103343867 0.8556754796452044 1.0 1.0 10 O00459,Q14118,O75431 3 +Dyskinesia 0.2701056163524653 0.1807807292312515 0.8565396897196471 1.0 1.0 74 Q01105,Q96N66,O95169,P02792,Q15043,Q9P0J0,Q9NZ01,P04062,P00846,Q9UBX3,Q5BJH7,O43819,Q9BTV4,Q9UQN3,Q9BPX6 15 +Postural instability 0.3002295303105762 0.1781161161339744 0.858631785565688 1.0 1.0 19 O75503,Q9NR77,P41440,Q709C8,P04062 5 +Impacted tooth 0.5280630881909674 0.1774190937737222 0.8591792105613154 1.0 1.0 3 O75844 1 +Accessory spleen 0.3694968675832056 0.1772042888323466 0.8593479269774535 1.0 1.0 7 O95202,Q15904 2 +Epistaxis 0.3207259814113655 0.174638207727799 0.8613639244807432 1.0 1.0 14 P01889,P20936,P04062,P38435,P49257 5 +Limb fasciculations 0.4166765361903491 0.1737579642529428 0.862055681437002 1.0 1.0 4 P04792,Q16637 2 +Periorbital fullness 0.2994552179014266 0.1731100361904622 0.8625649363128727 1.0 1.0 19 P07437,Q7LGA3,P38159 3 +Acute coronary syndrome 0.3038399399029332 0.1726196140258624 0.862950433576346 1.0 1.0 18 P06280,O75844,Q9NZ08,Q9Y4P3 4 +Abnormality of the clitoris 0.3036599773129278 0.1714995049065132 0.8638310197024581 1.0 1.0 18 P16435,P40855,O75381 3 +Impaired pain sensation 0.2991359995618187 0.171051040637906 0.8641836323149719 1.0 1.0 19 O15269,P07196,Q9NR77,O95831 4 +Intestinal pseudo obstruction 0.3331529906017924 0.1707656235675314 0.8644080604019106 1.0 1.0 11 P00403 1 +Abnormality of the supraorbital ridges 0.2928280136960263 0.1702144972202233 0.864841450955603 1.0 1.0 23 Q6NUK1,O75381,P38159,P16435,P40855 5 +Abnormal clavicle morphology 0.3033856499586175 0.1697937297937592 0.8651723582274731 1.0 1.0 18 O75431,Q15738,Q04656,P02545,Q8NC56,O75844 6 +Abnormality of blood circulation 0.2629535599680234 0.1656921058389307 0.8683992588103984 1.0 1.0 68 Q9Y487,Q9NZ08,O75844,P38435,Q9UHX1,P04062,P21912,O76024,Q9UJS0,P21964,P23786 11 +Abnormal gastrointestinal motility 0.2849788399309012 0.165555179911376 0.8685070216794153 1.0 1.0 29 P06280,Q5HYI8,O76024,P35637,Q9NRG9,Q01844,P00403 7 +Abnormality of the septum pellucidum 0.2791543579050792 0.1640095119906189 0.8697236557263692 1.0 1.0 44 O43505,Q96N66,Q9UJX6,Q9BVA1,Q9H9S5,O96028,P51571,Q9NZ01,Q69YQ0,Q15392,Q14118,P55011,Q9NX14,Q9BV10,O95202 15 +Enlarged posterior fossa 0.2770571590719762 0.1628444663164024 0.8706408964706758 1.0 1.0 48 O43505,Q9Y487,P07437,Q10713,P23786 5 +Abnormal circulating ferritin concentration 0.3657330621671129 0.1627665815373372 0.8707022213959053 1.0 1.0 7 P41440,Q9Y276 2 +Abnormal glial cell morphology 0.2587226983319277 0.1626224052506492 0.8708157449864316 1.0 1.0 64 O95169,P35637,Q9UHD9,P20700,Q16134,O95831,P04062,P00846,Q10713,Q7KZN9,O43819,Q9UQN3 12 +Limitation of neck motion 0.5206177112307173 0.1623977797573861 0.8709926191290975 1.0 1.0 3 O94905 1 +Skin vesicle 0.3273761549509225 0.1614870549794999 0.8717098061768844 1.0 1.0 12 P16615 1 +Abnormal endocardium morphology 0.3129909134078358 0.1613382370135592 0.8718270089430866 1.0 1.0 15 P06280,P04062,Q9NZ08 3 +Abnormally folded helix 0.3127231853728109 0.1598463279106683 0.873002128852957 1.0 1.0 15 P21964 1 +Abnormal blood sodium concentration 0.3306977943732055 0.1590689012627257 0.873614589416019 1.0 1.0 11 Q13423 1 +Typical absence seizure 0.32256205994662 0.1588967405444215 0.8737502287391083 1.0 1.0 13 Q13510 1 +Vertebral wedging 0.539769082745343 0.1583470926947641 0.8741833015977816 1.0 1.0 2 Q96AY3 1 +Abnormal foveal morphology 0.4098202824133531 0.1565224401834191 0.8756212325238055 1.0 1.0 4 Q9Y6K9,P35221,Q86YV9 3 +Lactic acidosis 0.2821514121424024 0.1522733378937179 0.8789713529509939 1.0 1.0 89 P09622,Q5XKP0,Q6P4A7,Q70HW3,Q86Y39,Q53H12,Q9Y276,Q96CU9,Q9Y6M9,O96000,Q9NPL8,Q10713,Q9UJS0,O43819,P00403,Q8IUX1 16 +Skin dimple 0.2872891626623889 0.1502830828742126 0.8805412793186032 1.0 1.0 26 Q969X5,Q5H8A4,Q9UM00,O96028,Q8TAA9,Q9NX14,O95202,Q9Y4P3 8 +Mandibular prognathia 0.2785085336403728 0.1488469256216152 0.8816744217547818 1.0 1.0 39 Q6NUK1,Q7RTS9,Q9NVI7,Q9UHX1,P16278 5 +Secondary growth hormone deficiency 0.4066110397946195 0.1487067575591784 0.8817850287705611 1.0 1.0 4 O00170,Q99496,Q969G3 3 +Abnormal size of pituitary gland 0.4066110397946195 0.1487067575591784 0.8817850287705611 1.0 1.0 4 Q99496,Q969G3,P35222 3 +Premature skin wrinkling 0.2909362567389637 0.1486306397614664 0.8818450945067933 1.0 1.0 20 O75844 1 +Ectopic kidney 0.303607335538949 0.1468627780289026 0.8832403321168725 1.0 1.0 17 Q8TAA9,Q9Y2U8,Q9UHX1 3 +Hypertrichosis 0.2918331338131541 0.1454899088165827 0.8843240825775538 1.0 1.0 100 P20674,Q6NUK1,O95169,Q9H6U8,Q9UHX1,Q9P0J0,Q96CU9,O94905,Q9Y2U8,P16278,P15586,P54802,Q7KZN9,O43819,Q96A33,P00403 16 +Abnormal synaptic transmission at the neuromuscular junction 0.2823319338104576 0.1445017100346368 0.885104306211641 1.0 1.0 29 P35637,Q15165,Q92804,Q9UHD9 4 +Abnormal thyroid stimulating hormone level 0.5311096856959546 0.143693139203552 0.8857427890965694 1.0 1.0 2 O14654 1 +Hepatocellular adenoma 0.5311096856959528 0.1436931392035489 0.8857427890965719 1.0 1.0 2 O00330 1 +Missing ribs 0.3236810607504711 0.1434017622658348 0.8859728912731253 1.0 1.0 12 Q8TAA9 1 +Retinal dystrophy 0.265647784442637 0.141310831329349 0.8876243933149977 1.0 1.0 58 O43505,O75381,Q9Y276,Q6P4Q7,P40855,Q14118,Q10713,P38435,P00846,Q15067 10 +Alkalosis 0.5094642284247699 0.1411862300560612 0.8877228239314345 1.0 1.0 3 O00170,P01889 2 +Overlapping toe 0.2895534101010926 0.1408642352872259 0.8879771964712226 1.0 1.0 21 Q15907,Q96A33,Q9UHX1 3 +Decreased facial expression 0.2771734980742041 0.1407003951613857 0.8881066329081415 1.0 1.0 35 P12235,Q05086,Q969X5,Q9H9S5,P02792,Q15043,Q04656,P04062,O75787 9 +Aplasia hypoplasia of the patella 0.4030808729139986 0.1402973647411047 0.8884250463648959 1.0 1.0 4 Q9Y5S9,Q9H1A4,Q96AY3 3 +Memory impairment 0.2769113203060855 0.1366190552561237 0.8913319138157889 1.0 1.0 36 P01889,O43681,Q9NZ08,Q9Y4W6,Q13501,Q8WVX9,Q9UJS0,O96008,Q9NZJ7,Q969G3,Q9UQN3,P00403 12 +Lower limb asymmetry 0.3636562719236469 0.1361532415629495 0.8917001386823062 1.0 1.0 6 P20936,P07437 2 +Abnormal circulating androgen level 0.3216354022952798 0.1335257100610694 0.8937776326327409 1.0 1.0 12 Q13423 1 +Gonosomal inheritance 0.2601358458467253 0.1316590503994014 0.8952539765295593 1.0 1.0 68 P06280,O75027,Q9UHD9,P38159,P13473,P55795,Q04656,P51571,O95831,Q9NVH6,P51572,O75787,Q9NX14,P50402,Q15904 15 +Bifid nasal tip 0.5227710070557984 0.1305241630911874 0.8961517382846809 1.0 1.0 2 P21281 1 +Expressive language delay 0.3307011988661722 0.1304627272473675 0.8962003414091329 1.0 1.0 10 P21912 1 +Elevated urinary delta aminolevulinic acid 0.3979460847240151 0.1284202674766038 0.8978163928265657 1.0 1.0 4 P50336,P16930,P36551 3 +Ileus 0.3979460847240075 0.1284202674765864 0.8978163928265794 1.0 1.0 4 P50336,P16930,Q01844 3 +Esodeviation 0.2752964860987306 0.1268987489172626 0.8990205368563364 1.0 1.0 34 P20700,Q9NVI7,Q96MW5,Q969N2,Q9HD42,Q9H6U8,P39656,Q9UHX1,P04062,O43924,Q9UBB6,P53007,P25054,P00387,Q8N766 15 +Episodic ataxia 0.3665806574063475 0.1261010781578812 0.8996519140386896 1.0 1.0 5 O14936,Q9H936,P09471 3 +Collectionism 0.4994143972520231 0.1234101165228237 0.9017823464852752 1.0 1.0 3 Q9UQN3 1 +Lack of insight 0.4994143972520231 0.1234101165228237 0.9017823464852752 1.0 1.0 3 Q9UQN3 1 +Eeg with continuous slow activity 0.4994143972520231 0.1234101165228237 0.9017823464852752 1.0 1.0 3 Q9UQN3 1 +Anal atresia 0.2820569302672983 0.1202068369885148 0.9043193019169388 1.0 1.0 27 Q8TAA9 1 +Sudden loss of visual acuity 0.5150737652341181 0.1191797101782563 0.905132981001176 1.0 1.0 2 P35222 1 +Pituitary prolactin cell adenoma 0.5150737652341175 0.1191797101782552 0.9051329810011768 1.0 1.0 2 P10644 1 +Elevated circulating growth hormone concentration 0.5150737652341175 0.1191797101782552 0.9051329810011768 1.0 1.0 2 P10644 1 +Abnormality of the proximal phalanx of the thumb 0.4963105550208642 0.1181767845821686 0.9059275842616614 1.0 1.0 3 Q15233,O60828 2 +Abnormal number of permanent teeth 0.4963105550208571 0.1181767845821563 0.9059275842616712 1.0 1.0 3 Q12959,Q14696 2 +Aplasia hypoplasia of the abdominal wall musculature 0.3631628688439542 0.1166473060135625 0.9071395488013324 1.0 1.0 5 Q6NUK1 1 +Abnormality of complement system 0.3923848921507613 0.1160359012988284 0.907624088840657 1.0 1.0 4 Q03252 1 +Facial hemangioma 0.3625942398423211 0.1150952936936715 0.9083695902034516 1.0 1.0 5 P20936,P16435 2 +Thick corpus callosum 0.3917425871165534 0.1146378445228293 0.9087321818465752 1.0 1.0 4 O00459 1 +Micronodular cirrhosis 0.3366146368302512 0.1134935599790876 0.9096392684866604 1.0 1.0 8 O75787,P11717 2 +Broad jaw 0.5105837075048035 0.1129173122055722 0.9100961109575728 1.0 1.0 2 O00170 1 +Abnormal circulating bilirubin concentration 0.2797305011241108 0.1125686075446137 0.910372574366368 1.0 1.0 28 P41440,O75648,P40855,Q9UJS0,P23786,Q9UGP8,O75845 7 +Parkinsonism with favorable response to dopaminergic medication 0.3204091030062542 0.1115219641903449 0.9112024493325064 1.0 1.0 11 Q9NZJ7 1 +Bicarbonaturia 0.5080179602309134 0.109454985830826 0.912841623290984 1.0 1.0 2 Q01968 1 +Low molecular weight proteinuria 0.5080179602309134 0.109454985830826 0.912841623290984 1.0 1.0 2 Q01968 1 +Renal phosphate wasting 0.5080179602309115 0.1094549858308235 0.912841623290986 1.0 1.0 2 O14745 1 +Abnormal lymphocyte morphology 0.2737645210784435 0.1092715239693452 0.912987131905588 1.0 1.0 36 O95470,P00813,Q03252,P04066,O75787,P16278,Q9BV10 7 +Congenital malformation of the right heart 0.3600262503552728 0.10816088255055 0.9138680740666538 1.0 1.0 5 P40855 1 +Focal motor seizure 0.2888981694537407 0.106595619863157 0.9151097936296252 1.0 1.0 19 O75503,P21912 2 +Mixed hypo and hyperpigmentation of the skin 0.3876765083440342 0.1059435535761189 0.9156271377387252 1.0 1.0 4 Q9H488,P02545,P52788 3 +Hyperphenylalaninemia 0.5048107761385464 0.1052448362017943 0.9161815341042354 1.0 1.0 2 P61457 1 +Abnormal temper tantrums 0.3338182481146517 0.1030495121620091 0.9179236750643996 1.0 1.0 8 P04062 1 +Orchitis 0.486251071656914 0.1020468310371751 0.9187195032841078 1.0 1.0 3 Q9NZ08 1 +Pulmonary embolism 0.486251071656914 0.1020468310371751 0.9187195032841078 1.0 1.0 3 Q9NZ08 1 +Pleuritis 0.486251071656914 0.1020468310371751 0.9187195032841078 1.0 1.0 3 Q9NZ08 1 +Hashimoto thyroiditis 0.5003207184092332 0.099568254484612 0.9206870977991513 1.0 1.0 2 P54098 1 +Onychogryposis 0.4837985242220162 0.0983062228413381 0.9216891370062704 1.0 1.0 3 Q9Y6K9,P53634 2 +Abnormal facial expression 0.2728437178756143 0.0981944853275696 0.9217778613741872 1.0 1.0 40 Q9NR77,P12235,Q05086,Q969X5,Q9H9S5,P02792,Q15043,Q86U42,Q04656,Q8WXI9,P04062,O75787 12 +Acute pancreatitis 0.4836411145780691 0.0980687024259163 0.9218777395458562 1.0 1.0 3 Q96MF7 1 +Cholestasis 0.2679146240684539 0.0966007836535126 0.9230434341415548 1.0 1.0 79 Q5HYI8,Q13510,P38571,O75845,O75381,Q16625,Q9Y276,O15118,Q04656,P40855,Q9UJS0,P35670,P00374,O75787,Q15904 15 +Broad alveolar ridges 0.4964720974983903 0.0949022221799101 0.9243924914438462 1.0 1.0 2 P21281 1 +Agenesis of permanent teeth 0.4961513790891524 0.0945216210405639 0.9246948082261794 1.0 1.0 2 Q14696 1 +Ocular pain 0.4783561051530802 0.090272604635541 0.9280705895818826 1.0 1.0 3 Q15043 1 +Protrusio acetabuli 0.4778864861789753 0.0895965901295681 0.9286077941922968 1.0 1.0 3 O75718 1 +Hydrops fetalis 0.2705209826026816 0.0891439480551626 0.9289675109029558 1.0 1.0 46 P08236,Q13510,Q9BT22,P04062,O96000,P16278,P10619 7 +Bladder diverticulum 0.3254654680101715 0.08779511826565 0.9300395178434326 1.0 1.0 9 Q9NWM8,Q04656 2 +Streak ovary 0.3449214459699955 0.0876199727324587 0.930178727286799 1.0 1.0 7 P51809,P57740,P82650,P49590,O75616 5 +Writer s cramp 0.3785702788568106 0.087454723424682 0.930310072955764 1.0 1.0 4 P02792,O14656 2 +Short palpebral fissure 0.2785801563018176 0.0867479041997082 0.9308718978624202 1.0 1.0 26 Q6NUK1,P55795,P07437,P98175,Q9UHX1,O75844 6 +Lymphoproliferative disorder 0.3512038523274522 0.0852807478281335 0.9320381967750933 1.0 1.0 5 Q9H0U3,P33991,P17812,P50851 4 +Nocturnal hypoventilation 0.4746512367939159 0.0850133471269997 0.93225077965199 1.0 1.0 3 Q9H9S5 1 +Subependymal cysts 0.4738530638434425 0.0839024019134258 0.933134029845848 1.0 1.0 3 Q9BSJ2,O00330 2 +Scleral staphyloma 0.3764441591784356 0.0833343277180893 0.9335857056406424 1.0 1.0 4 Q969N2,P36404,P40939 3 +Acanthosis nigricans 0.3137744369901419 0.0822023249034727 0.9344858246989454 1.0 1.0 11 Q96MF7,P02545,O75431 3 +Agenesis of incisor 0.4719281360282347 0.0812552803968229 0.9352389374114828 1.0 1.0 3 Q12959,P38919 2 +Hypoplasia of the radius 0.313474163366608 0.0809015869596246 0.9355202178932608 1.0 1.0 11 Q9BV10,Q02127 2 +High pitched voice 0.3187778715185873 0.0803816914055347 0.9359336879232876 1.0 1.0 10 O75844,O75431 2 +Inappropriate antidiuretic hormone secretion 0.4820397690827372 0.079000110125784 0.9370325354708506 1.0 1.0 2 Q13724 1 +Abnormality of upper limb joint 0.3013727713014443 0.07854508303192 0.937394469893288 1.0 1.0 117 Q7LGA3,Q9Y3E5,Q04656,Q15392,Q02127,O95202,P23786,Q96L58,P50402,Q13510,P16435,Q9H6K4,P07196,Q9NR77,Q7RTS9,O95831,O94905,Q9BV10,P37268,O75844,P42892,Q9BTV4,Q9Y4P3,Q9BUB7,P16278 25 +Olivopontocerebellar hypoplasia 0.3476725521669377 0.0765379207260114 0.9389911460632544 1.0 1.0 5 Q96GM8,Q9UNW1,Q99700,Q9H9S5 4 +Pericarditis 0.3726298168986193 0.0761288050192854 0.9393166235411244 1.0 1.0 4 Q9NZ08 1 +Abnormality of the small intestine 0.2655057099216655 0.0750655480395246 0.940162559140158 1.0 1.0 52 Q14566,Q15645,Q9BT22,P38571,P98175,Q9H6U8,Q9Y3E5,Q8NCH0,O95202,Q96A33 10 +Anal stenosis 0.4667949951876891 0.0744170324991913 0.940678556405978 1.0 1.0 3 Q08J23,Q69YQ0 2 +Pollakisuria 0.4667949951876765 0.0744170324991746 0.9406785564059912 1.0 1.0 3 Q8WVX9,P54886 2 +Spina bifida 0.269637634942895 0.0721409499859757 0.9424897377281996 1.0 1.0 37 Q9UHX1,Q8TAA9,Q10713,P21964,O75845 5 +Hypoplasia of the uterus 0.3212651322756823 0.0718267508607407 0.9427397836898628 1.0 1.0 9 O75616,Q9NX14,Q16740 3 +Tremor 0.3458524200130043 0.0711413923331105 0.9432852252894146 1.0 1.0 172 O14773,Q99720,P41440,Q9NW15,O75027,P04062,P35637,Q14108,Q8NI60,Q13510,P02792,P21912,Q9Y2U8,Q9UJS0,Q10713,Q9H6K4,P04350,P07196,Q8NC56,P00846,O75503,Q9NR77,P12235,O75306,Q9Y4W6,Q15043,O95831,O60313,O94905,O43924,P35670,Q9NZJ7,Q9BPX6,Q9Y4P3,Q05086,Q6P4A7,P20700,O43681,Q9NQZ5,Q9BUB7,O95140,O76024,O75787,Q5JRX3,Q6DKK2 45 +Macular dystrophy 0.4737010904425865 0.0709170887242774 0.9434637427829604 1.0 1.0 2 Q8NHS3 1 +Chromosomal breakage induced by ionizing radiation 0.3697047496790802 0.0707655092177786 0.9435843826357782 1.0 1.0 4 Q99496,Q969G3,Q12824 3 +Abnormality of canine 0.4733803720333465 0.0706217601575308 0.9436987915495796 1.0 1.0 2 P25054 1 +Abnormal branching pattern of the aortic arch 0.3691377039410964 0.06974208987223 0.9443989404486924 1.0 1.0 4 O00459 1 +Agenesis of lateral incisor 0.471776779987166 0.0691620828908616 0.944860604275015 1.0 1.0 2 Q12959 1 +Self mutilation 0.310710155180233 0.0690379961198919 0.9449593751057566 1.0 1.0 11 O75962,Q9UM00,Q8WXI9,Q10713 4 +Obstructive sleep apnea 0.3076423944203048 0.0687574058045118 0.9451827230515706 1.0 1.0 12 Q15233,Q969N2,P51530,P53007,Q96A33 5 +Abnormal sacrum morphology 0.267458388542876 0.0683989663458122 0.9454680446415702 1.0 1.0 32 P01889,Q14739,P61978,Q5H8A4,Q9UM00,O96028,P04066,Q8TAA9,Q9NX14,O95202,Q9Y4P3 11 +Renal corticomedullary cysts 0.4692110327132721 0.0668849122236372 0.946673324440755 1.0 1.0 2 Q7Z494 1 +Abnormal peripheral action potential amplitude 0.3198832626976182 0.0666652419346964 0.9468482056476116 1.0 1.0 9 O15269,Q92734,P19367,Q96RL7 4 +Rhabdomyolysis 0.2951435004935758 0.0661297762965536 0.9472745046744168 1.0 1.0 15 P23786,Q9Y276 2 +Choroid plexus cyst 0.459416105229387 0.0651432956082737 0.9480599087087812 1.0 1.0 3 Q7Z494,O43175 2 +Dysgammaglobulinemia 0.4666452854393786 0.0646785711469596 0.9484299248380852 1.0 1.0 2 Q9Y6K9 1 +Abnormal rib ossification 0.3661745827984616 0.0644801499192469 0.9485879122853952 1.0 1.0 4 Q5F1R6,Q14739,P61011 3 +Broad based gait 0.2772012785412937 0.0615956603274569 0.9508848329391768 1.0 1.0 22 O14773,P04062,Q05086 3 +Abnormal peripheral nervous system morphology 0.3316994249042667 0.0608604657552106 0.9514703348083025 1.0 1.0 155 Q99720,O75381,Q9Y3E5,Q04656,O15269,P35637,Q13510,Q9UHD9,Q9BQT8,P21912,P40855,P07196,P00846,Q9UQN3,Q9NR77,Q15043,Q9GZY8,O95831,O60313,O95721,Q9NZJ7,O43819,Q9BV10,P00403,Q9BPX6,P20700,Q9NVI7,O43681,Q8IV08,Q9UHX1,P22626,Q9HC21,O95140,O76024,Q9BUF5,Q15067,Q6DKK2 37 +Buphthalmos 0.3638153471890147 0.0603936601110286 0.9518421079408496 1.0 1.0 4 Q14118 1 +Polycythemia 0.4592687620269317 0.0587198591171978 0.953175241341374 1.0 1.0 2 P00387 1 +Heinz bodies 0.4586273252084636 0.0582280648134578 0.9535669661531304 1.0 1.0 2 O14936 1 +Abnormality of the amniotic fluid 0.2711438830521878 0.0563695642422627 0.9550474026060668 1.0 1.0 86 Q15645,Q7LGA3,Q6NUK1,Q9NVI7,Q9BT22,Q70HW3,P16435,P23786,Q9H6U8,Q9UHX1,Q9UM00,Q9BUB7,P04062,Q9BV10,P21964,O75844,Q96L58 17 +Hip dislocation 0.2527840992600207 0.0559903350660358 0.9553495065843168 1.0 1.0 67 Q9Y487,Q9H9S5,Q9H6U8,Q15738,Q9Y3E5,Q04656,O96028,Q9UHX1,Q02127,Q8TD16,P02545,O95202,O75844,Q96L58,Q96A33,Q9H0W5 16 +Bloody diarrhea 0.361039794608476 0.0557027404803398 0.9555786163067082 1.0 1.0 4 Q15477,P25054,Q02241 3 +Abnormal epidermal morphology 0.2873165482038128 0.0546936352245146 0.9563825401295412 1.0 1.0 17 P16615,P98194,P20936,Q06136,P02545,O75844 6 +Skeletal muscle atrophy 0.3413015428884718 0.054341991905473 0.9566626942578328 1.0 1.0 168 Q99720,Q9NWM8,Q9Y3E5,Q04656,O15269,P35637,P50402,O75298,P50416,Q13510,Q9UHD9,Q9BQT8,O75477,O14979,P21912,Q9Y2U8,P07196,Q9UQN3,Q9NR77,Q92804,O00459,O95831,O60313,O94905,O43819,Q15165,Q9BTV4,O43505,Q6P4A7,Q9NVI7,P13473,Q9BVA1,P22626,Q9HC21,Q8TD16,P16278,Q9NPL8,Q14118,Q6DKK2 39 +Childhood onset 0.2674409102153452 0.0534714702506494 0.9573562615607608 1.0 1.0 37 Q9NR77,Q14566,P22830,Q5JRX3,P50402,Q15904 6 +Abnormality of the adrenal glands 0.2625446828469696 0.0532076915799688 0.957566427303782 1.0 1.0 53 O75381,P38571,Q13423,O95470,P16435,P21912,O75844 7 +Heterotropia 0.2647111373180438 0.053193129731367 0.9575780295475144 1.0 1.0 50 Q96MW5,Q9Y3E5,P04062,Q9UBB6,P53007,P55795,Q969N2,P00387,Q10471,Q99496,Q9HD42,Q9UEY8,O43924,O43819,Q8N766,Q05086,P20700,Q9NVI7,Q15233,Q9H6U8,P39656,Q9UHX1,P25054 23 +Uterus didelphys 0.450930083386779 0.052643770501328 0.9580157414847144 1.0 1.0 2 O14974 1 +Abnormal pelvis bone ossification 0.4509300833867784 0.0526437705013274 0.9580157414847148 1.0 1.0 2 Q14739 1 +Lethal skeletal dysplasia 0.4509300833867784 0.0526437705013274 0.9580157414847148 1.0 1.0 2 Q14739 1 +Abnormality of mouth size 0.3015803695736773 0.0509373204400107 0.9593754666856288 1.0 1.0 120 Q9Y487,Q7LGA3,Q6NUK1,Q9UM00,P51571,P04062,Q15392,Q01105,P55795,P16435,Q9NX62,Q8NCH0,Q8NC56,P07437,O00459,O94905,P21964,O75844,Q9Y4P3,Q05086,Q9NVI7,O75431,Q9H6U8,P16278,P15586 25 +Short ribs 0.3155891086036229 0.0509226985448553 0.9593871181490528 1.0 1.0 9 Q9BV10,Q96HY6,Q15738 3 +Eeg with focal epileptiform discharges 0.2672967260376116 0.04928013843177 0.9606960475192324 1.0 1.0 40 O75503,Q96N66,Q05086,Q5H8A4,Q9UBX3,Q14118 6 +Peripheral neuropathy 0.3368673267255186 0.0480324370230887 0.9616903914264308 1.0 1.0 163 Q9P0J0,Q9Y2R0,Q15041,Q7KZN9,O15269,O95169,Q96CU9,Q10713,P07196,P00846,Q9NR77,P05023,Q9GZY8,O95831,O60313,O95721,O94905,P35670,Q9NZJ7,O43819,P00403,Q9BPX6,Q9NVI7,O95470,Q8IV08,P04066,Q9HC21,O76024,Q9NPL8,P54802 30 +Incomprehensible speech 0.4432328415650997 0.0476224208947164 0.962017163009896 1.0 1.0 2 Q8WXI9 1 +Abnormal renal echogenicity 0.4427333974975905 0.0465274628717688 0.9628898455775146 1.0 1.0 3 Q9NP81,Q15058 2 +Mediastinal lymphadenopathy 0.3343511931205153 0.0457338459754283 0.963522386835838 1.0 1.0 5 Q9H0U3,Q01844 2 +Edema of the dorsum of feet 0.44002565747273 0.0456883854365464 0.963558621222167 1.0 1.0 2 Q9Y263 1 +Edema of the dorsum of hands 0.44002565747273 0.0456883854365464 0.963558621222167 1.0 1.0 2 Q9Y263 1 +Increased level of l fucose in urine 0.4377806286080761 0.044387922039375 0.964595188977075 1.0 1.0 2 P25054 1 +Hyperaldosteronism 0.4377806286080729 0.0443879220393733 0.9645951889770764 1.0 1.0 2 Q01968 1 +Hyperostosis 0.2947003364863687 0.0427092422064639 0.9659333120783528 1.0 1.0 14 Q15043,Q96L58,Q9Y2U8 3 +Nephrogenic diabetes insipidus 0.434573444515706 0.0426044384751848 0.9660168573131228 1.0 1.0 2 Q9H267 1 +Lung adenocarcinoma 0.4379210779595718 0.0417427690495918 0.966703758885401 1.0 1.0 3 Q99496,P30154 2 +Multifocal seizures 0.3316010666262012 0.0411501308893233 0.9671762097524064 1.0 1.0 6 Q9HA77,Q96S52 2 +Flared metaphysis 0.3039722073904259 0.0409688943549868 0.9673206937418708 1.0 1.0 11 Q9H6U8,Q96L58 2 +Abnormality of the calcaneus 0.312763501655864 0.0408132471581945 0.9674447784538592 1.0 1.0 9 Q7RTS9,O75787,Q9H0W5 3 +Joint laxity 0.2554031284653025 0.0408125739801887 0.9674453151250456 1.0 1.0 71 Q9Y487,Q32P28,Q5H8A4,P55795,Q96HY6,Q04656,Q9UHX1,P16278,Q8NCH0,Q96L58,Q96A33 11 +Abnormal muscle glycogen content 0.3316211878009672 0.0398500095360482 0.9682127060262864 1.0 1.0 5 O75648,Q9BUK6,P13807,P46976 4 +Abnormality of the lymphatic system 0.321572048429332 0.0378834658157765 0.9697805959535046 1.0 1.0 145 Q9BT22,Q16625,O15118,P04062,O95202,Q14108,Q13510,Q9Y2U8,Q9UJS0,Q10713,Q15904,Q5HYI8,P00813,P35670,Q9NZJ7,P21964,P10619,O75845,P08236,Q9NZ08,P38571,Q9H6U8,P04066,P16278,P15586,P54802,Q96A33 27 +Abnormal chromosome morphology 0.4249518922386087 0.0377549463081764 0.9698830663767696 1.0 1.0 2 O95453 1 +Large face 0.2511228121620139 0.0371798827807807 0.9703415787360076 1.0 1.0 62 Q7LGA3,Q9NVI7,Q04656,O95721,O43924,Q10713,Q9BV10,P21964 8 +Small cerebral cortex 0.4230275817831894 0.0368710312901314 0.97058783771683 1.0 1.0 2 Q15058 1 +Unconjugated hyperbilirubinemia 0.4321462945139555 0.0363338038726794 0.971016196133774 1.0 1.0 3 O14936,P11413 2 +Myokymia 0.4185375240538793 0.0349141085598973 0.9721482304686456 1.0 1.0 2 Q9Y6X9 1 +Tall stature 0.2606861512420068 0.0344601703420818 0.972510202933369 1.0 1.0 53 Q7LGA3,Q9UJX6,P36543,Q13423,Q15233,Q9NWM8,P61978,P16435,Q15738,Q5H8A4,O96028,P04350,O75648,P51530,Q3ZCQ8,Q8NCH0,O95202 17 +Extramedullary hematopoiesis 0.4299819725541529 0.034398156661388 0.9725596533745902 1.0 1.0 3 P98175 1 +Spontaneous hemolytic crises 0.4172546504169275 0.0343813989687106 0.972573016174712 1.0 1.0 2 P11166 1 +Lambdoidal craniosynostosis 0.3470353725079669 0.0339400792718808 0.9729249329487076 1.0 1.0 4 P16435 1 +Hiatus hernia 0.3021846426234793 0.0337308465844083 0.9730917809450036 1.0 1.0 11 Q8NCH0 1 +Enterocolitis 0.4153303399615122 0.0336037376443812 0.9731931417438902 1.0 1.0 2 P49748 1 +Intestinal polyp 0.2764905047906711 0.0330654624595529 0.973622384645482 1.0 1.0 19 P21912,P42892,Q04656 3 +Depression 0.2848080416422402 0.0324473794045614 0.9741152790598746 1.0 1.0 103 Q9NZ01,P04062,P35637,P06280,Q96N66,Q9UHD9,P50897,Q9UQN3,P12235,Q92804,P35670,Q9NZJ7,Q15165,P21964,P00403,Q9Y4P3,P20700,O43681,Q9Y276,O76024,Q6DKK2 21 +Hyporeflexia 0.300751176472829 0.0317217087576676 0.974693982512032 1.0 1.0 121 Q99720,P41440,Q8TB36,Q9H9S5,Q9Y3E5,Q04656,P04062,O15269,P35637,Q13501,O14979,P02545,Q10713,P07196,Q16637,P00846,Q9NR77,P12235,P83436,P05023,O95831,Q9NZJ7,O43505,O43681,Q5H8A4,O75648,Q9HC21,O95140,Q9NWS8,Q8TD16,Q14118,P54802,O75787,Q15067 34 +Hypoplasia of the fovea 0.4095574085952437 0.0314197873877514 0.9749347608874817 1.0 1.0 2 Q9Y6K9 1 +Synostosis of joints 0.264903368773101 0.0304632618373521 0.9756975925805592 1.0 1.0 38 P16435,Q04656,Q9UHX1,Q02127,Q8TAA9,O95202,Q96L58,Q9Y4P3 8 +Renal tubular atrophy 0.326805778491176 0.0298293246068715 0.9762031715137992 1.0 1.0 5 Q9NQH7,Q8WUM0,Q7Z494,P57740 4 +Neonatal respiratory distress 0.2719074369776081 0.0293038784561448 0.9766222336714409 1.0 1.0 23 P23786 1 +Hydranencephaly 0.4021808851828077 0.0289360924086673 0.97691556008586 1.0 1.0 2 O43175 1 +Dark urine 0.3976908274534921 0.0275811878359879 0.9779961858897206 1.0 1.0 2 P36551 1 +Papilledema 0.2715547314278153 0.0272723098260149 0.9782425422087612 1.0 1.0 20 Q7LGA3 1 +Cystic hygroma 0.3260872807705256 0.0271456323317576 0.9783435788185189 1.0 1.0 7 P61978,Q96S52,Q14739 3 +Esophageal atresia 0.3259473346178518 0.0265744892792762 0.9787991206780036 1.0 1.0 6 Q15149,Q9Y2W2,Q8NCM8,Q9BXW9,Q96GM5 5 +Hypothalamic hypothyroidism 0.4194662036169519 0.0256809473530708 0.979511820655079 1.0 1.0 3 Q969G3 1 +Progressive pulmonary function impairment 0.4194662036169519 0.0256809473530708 0.979511820655079 1.0 1.0 3 Q969G3 1 +Ear pain 0.4194662036169519 0.0256809473530708 0.979511820655079 1.0 1.0 3 Q969G3 1 +Brain stem compression 0.4194662036169519 0.0256809473530708 0.979511820655079 1.0 1.0 3 Q969G3 1 +Decreased circulating follicle stimulating hormone concentration 0.4194662036169519 0.0256809473530708 0.979511820655079 1.0 1.0 3 Q969G3 1 +Intracranial meningioma 0.4194662036169519 0.0256809473530708 0.979511820655079 1.0 1.0 3 Q969G3 1 +Transient global amnesia 0.4194662036169519 0.0256809473530708 0.979511820655079 1.0 1.0 3 Q969G3 1 +Neuralgia 0.4194662036169519 0.0256809473530708 0.979511820655079 1.0 1.0 3 Q969G3 1 +Hypoplastic labia minora 0.4193134424125758 0.0255625108110582 0.979606288330502 1.0 1.0 3 Q9NP72,Q9H2M9 2 +Clitoral hypoplasia 0.4193134424125758 0.0255625108110582 0.979606288330502 1.0 1.0 3 Q9NP72,Q9H2M9 2 +Abnormal pleura morphology 0.2712783429237597 0.025317640199953 0.9798016035960118 1.0 1.0 23 Q8NCH0,Q9NZ08,Q96L58,P08236 4 +Sudden death 0.2697514935531712 0.0252014600539271 0.9798942723726104 1.0 1.0 26 P04899,Q9Y4P3,P02545,Q8NC56,Q9BTV4,P50402,P50416 7 +Pancreatic islet cell hyperplasia 0.4170676932948381 0.0238477554801933 0.9809740475018052 1.0 1.0 3 P53985,Q14739 2 +Sporadic 0.2686864768620216 0.0237035598449329 0.9810890664591532 1.0 1.0 27 Q05086,O96028,Q03252,P04062,P21912,Q9BWD1,O95202 7 +Melena 0.3797305965362364 0.0232046625025285 0.9814870194708564 1.0 1.0 2 P25054 1 +Prolonged bleeding following procedure 0.3797305965362353 0.0232046625025285 0.9814870194708564 1.0 1.0 2 P49257 1 +Esophageal carcinoma 0.4154635867821639 0.0226529224388283 0.9819271286392796 1.0 1.0 3 Q8N9N2,P25054 2 +Abnormal dentin morphology 0.3241271349631984 0.0220268274527398 0.982426555514082 1.0 1.0 6 Q96L58 1 +Aplasia hypoplasia affecting the anterior segment of the eye 0.2699361018934507 0.0219459365572922 0.9824910815128004 1.0 1.0 25 Q15645,Q7LGA3,P21912,O95202,Q9Y4P3 5 +Calcific stippling 0.3717126363053205 0.0217172252977859 0.9826735232125716 1.0 1.0 2 P51659 1 +Biventricular hypertrophy 0.41212563360019 0.0202454763042177 0.9838475504641152 1.0 1.0 3 Q9BV10 1 +Aplasia hypoplasia of the humerus 0.3031428533821027 0.0200625619635555 0.9839934653550836 1.0 1.0 10 Q9BV10,O00116 2 +Truncal ataxia 0.2834720627632003 0.0200554506013981 0.983999138259755 1.0 1.0 16 O75503 1 +Apneic episodes precipitated by illness fatigue stress 0.3540731237973025 0.0192507464917917 0.9846410752432913 1.0 1.0 2 P53007 1 +Aplasia hypoplasia of the retina 0.4096888033365425 0.0185541007492856 0.9851968188214408 1.0 1.0 3 Q9Y6K9,Q86YV9 2 +Delayed social development 0.3335471456061544 0.0174463970815787 0.9860804952595388 1.0 1.0 2 Q9UJX6 1 +Palmar telangiectasia 0.330660679923024 0.0172625861498711 0.9862271330801152 1.0 1.0 2 Q14739 1 +Gingival overgrowth 0.2685711772995798 0.0172144042911883 0.9862655709296356 1.0 1.0 26 P08236,P20700,O75845,Q9UM00,P16278,Q9Y4P3 6 +Menorrhagia 0.3120590121872956 0.0163824553141602 0.986929276503414 1.0 1.0 2 P49257 1 +Giant platelets 0.3120590121872957 0.0163824553141602 0.986929276503414 1.0 1.0 2 Q14739 1 +Abnormal heart valve physiology 0.2714024958120702 0.0162368255060155 0.9870454568255584 1.0 1.0 90 P06280,Q15645,Q6NUK1,O95169,Q9NZ08,O75431,Q9H6U8,Q8NC56,O00459,P00813,Q9UHX1,P04062,P16278,Q9NX14,O43819,O75844,Q96L58,Q15904 18 +Severe short limb dwarfism 0.4055061746633545 0.0157781088241491 0.9874114128914816 1.0 1.0 3 Q96MF7 1 +Anterior pituitary dysgenesis 0.2751763951250754 0.0156301210402854 0.9875294755001538 1.0 1.0 2 Q15233 1 +Patchy changes of bone mineral density 0.3332086102680286 0.0155025818777634 0.9876312247005216 1.0 1.0 4 Q13501 1 +Dicarboxylic aciduria 0.2688656482093183 0.0119202911774585 0.9904892089464452 1.0 1.0 24 O43772,Q16134,Q9H9P8,O75880,P23786 5 +Elevated urinary dicarboxylic acid level 0.3978184151427655 0.0110800971692564 0.9911595424251892 1.0 1.0 3 P50336,P36551 2 +Respiratory paralysis 0.3978184151427655 0.0110800971692564 0.9911595424251892 1.0 1.0 3 P50336,P36551 2 +Porphyrinuria 0.3978184151427655 0.0110800971692564 0.9911595424251892 1.0 1.0 3 P50336,P36551 2 +Alternating esotropia 0.3279814940034082 0.0092939136979062 0.9925846365037608 1.0 1.0 4 P25054,P20700 2 +Abnormal renal pelvis morphology 0.2572309297479744 0.0079217297492155 0.9936794402448434 1.0 1.0 54 O43505,Q5JRA6,P83436,P20700,O75381,O75718,P61978,P98175,P16435,Q15738,Q9H6U8,Q04656,P40855,O76024,Q8NCH0,P23786,O60826,P25054 18 +Abnormal mitochondrial number 0.3878729547641961 0.0057352391931623 0.9954239662818336 1.0 1.0 3 Q9BQP7,P51530 2 +Chronic lymphatic leukemia 0.3875521334616632 0.0055758927614753 0.995551104306063 1.0 1.0 3 O75792,Q9Y3Z3 2 +Neonatal alloimmune thrombocytopenia 0.3875521334616632 0.0055758927614753 0.995551104306063 1.0 1.0 3 O75792,Q9Y3Z3 2 +Csf pleocytosis 0.3875521334616632 0.0055758927614753 0.995551104306063 1.0 1.0 3 O75792,Q9Y3Z3 2 +Chronic leukemia 0.3875521334616632 0.0055758927614753 0.995551104306063 1.0 1.0 3 O75792,Q9Y3Z3 2 +Moyamoya phenomenon 0.3875521334616632 0.0055758927614753 0.995551104306063 1.0 1.0 3 O75792,Q9Y3Z3 2 +Csf lymphocytic pleiocytosis 0.3875521334616632 0.0055758927614753 0.995551104306063 1.0 1.0 3 O75792,Q9Y3Z3 2 +Chilblains 0.3875521334616632 0.0055758927614753 0.995551104306063 1.0 1.0 3 O75792,Q9Y3Z3 2 +Abnormal posterior segment imaging 0.3244548062784013 0.0053336103483391 0.9957444148264532 1.0 1.0 4 Q8WWY3 1 +Mild microcephaly 0.317051017010455 0.0050242841518018 0.9959912181120996 1.0 1.0 6 P21912 1 +Generalized osteoporosis 0.3788899582932326 0.0015647056178446 0.9987515460547528 1.0 1.0 3 P42224,P02545 2 diff --git a/msigdb_hp/selections.json b/msigdb_hp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..0525e9afc2fd5f26e973c09e78ba002f525d0c1a --- /dev/null +++ b/msigdb_hp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["11 pairs of ribs", "2 3 finger syndactyly", "2 3 toe cutaneous syndactyly", "2 3 toe syndactyly", "3 4 finger syndactyly", "3 methylglutaconic aciduria", "4 5 toe syndactyly", "Abdominal aortic aneurysm", "Abdominal distention", "Abdominal obesity", "Abdominal pain", "Abdominal wall muscle weakness", "Abducens palsy", "Abnormal 2nd finger morphology", "Abnormal 3rd finger morphology", "Abnormal 5th finger morphology", "Abnormal 5th finger phalanx morphology", "Abnormal abdomen morphology", "Abnormal acetabulum morphology", "Abnormal activity of mitochondrial respiratory chain", "Abnormal adipose tissue morphology", "Abnormal aggressive impulsive or violent behavior", "Abnormal aldolase level", "Abnormal anatomic location of the heart", "Abnormal anterior chamber morphology", "Abnormal anterior eye segment morphology", "Abnormal anterior horn cell morphology", "Abnormal aortic arch morphology", "Abnormal aortic morphology", "Abnormal aortic valve cusp morphology", "Abnormal aortic valve morphology", "Abnormal aortic valve physiology", "Abnormal arachnoid mater morphology", "Abnormal arm span", "Abnormal arterial physiology", "Abnormal astrocyte morphology", "Abnormal atrial arrangement", "Abnormal atrioventricular conduction", "Abnormal atrioventricular valve morphology", "Abnormal atrioventricular valve physiology", "Abnormal auditory evoked potentials", "Abnormal autonomic nervous system physiology", "Abnormal b cell morphology", "Abnormal b cell subset distribution", "Abnormal basal ganglia mri signal intensity", "Abnormal biliary tract morphology", "Abnormal bleeding", "Abnormal blistering of the skin", "Abnormal blood carbon dioxide level", "Abnormal blood chloride concentration", "Abnormal blood gas level", "Abnormal blood glucose concentration", "Abnormal blood inorganic cation concentration", "Abnormal blood ion concentration", "Abnormal blood monovalent inorganic cation concentration", "Abnormal blood phosphate concentration", "Abnormal blood potassium concentration", "Abnormal blood sodium concentration", "Abnormal blood transition element cation concentration", "Abnormal blood zinc concentration", "Abnormal bone structure", "Abnormal brain choline level by mrs", "Abnormal brain lactate level by mrs", "Abnormal brain n acetyl aspartate level by mrs", "Abnormal brain positron emission tomography", "Abnormal brainstem morphology", "Abnormal brainstem mri signal intensity", "Abnormal branching pattern of the aortic arch", "Abnormal breath sound", "Abnormal bronchoalveolar lavage fluid morphology", "Abnormal bronchus morphology", "Abnormal bronchus physiology", "Abnormal c peptide level", "Abnormal c reactive protein level", "Abnormal calcium phosphate regulating hormone level", "Abnormal cardiac atrium morphology", "Abnormal cardiac exercise stress test", "Abnormal cardiac septum morphology", "Abnormal cardiac test", "Abnormal cardiac ventricle morphology", "Abnormal cardiac ventricular function", "Abnormal cardiomyocyte morphology", "Abnormal carotid artery morphology", "Abnormal cartilage morphology", "Abnormal caudate nucleus morphology", "Abnormal cd4 cd8 ratio", "Abnormal cell morphology", "Abnormal cell proliferation", "Abnormal cellular composition of bronchoalveolar fluid", "Abnormal cellular phenotype", "Abnormal central sensory function", "Abnormal cerebellar vermis morphology", "Abnormal cerebral artery morphology", "Abnormal cerebral cortex morphology", "Abnormal cerebral vascular morphology", "Abnormal cerebral vein morphology", "Abnormal cerebral ventricle morphology", "Abnormal cerebrospinal fluid metabolite concentration", "Abnormal cervical curvature", "Abnormal cervical spine morphology", "Abnormal chorioretinal morphology", "Abnormal choroid morphology", "Abnormal choroid plexus morphology", "Abnormal chromosome morphology", "Abnormal ciliary body morphology", "Abnormal circulating acetylcarnitine concentration", "Abnormal circulating albumin concentration", "Abnormal circulating amino acid concentration", "Abnormal circulating amylase level", "Abnormal circulating androgen level", "Abnormal circulating apolipoprotein concentration", "Abnormal circulating arginine concentration", "Abnormal circulating aromatic amino acid concentration", "Abnormal circulating aspartate family amino acid concentration", "Abnormal circulating bilirubin concentration", "Abnormal circulating branched chain amino acid concentration", "Abnormal circulating carbohydrate concentration", "Abnormal circulating carboxylic acid concentration", "Abnormal circulating ceruloplasmin concentration", "Abnormal circulating cholesterol concentration", "Abnormal circulating citrulline concentration", "Abnormal circulating copper concentration", "Abnormal circulating creatinine concentration", "Abnormal circulating dehydroepiandrosterone concentration", "Abnormal circulating dicarboxylic acid concentration", "Abnormal circulating estrogen level", "Abnormal circulating fatty acid anion concentration", "Abnormal circulating fatty acid concentration", "Abnormal circulating ferritin concentration", "Abnormal circulating follicle stimulating hormone concentration", "Abnormal circulating free fatty acid concentration", "Abnormal circulating gaba concentration", "Abnormal circulating glutamine concentration", "Abnormal circulating glutamine family amino acid concentration", "Abnormal circulating glycine concentration", "Abnormal circulating gonadotropin concentration", "Abnormal circulating hormone concentration", "Abnormal circulating iga level", "Abnormal circulating ige level", "Abnormal circulating igg level", "Abnormal circulating igm level", "Abnormal circulating inhibin level", "Abnormal circulating lipid concentration", "Abnormal circulating long chain fatty acid concentration", "Abnormal circulating metabolite concentration", "Abnormal circulating methionine concentration", "Abnormal circulating monocarboxylic acid cocentration", "Abnormal circulating nitrogen compound concentration", "Abnormal circulating non proteinogenic amino acid concentration", "Abnormal circulating nucleobase concentration", "Abnormal circulating phenylalanine concentration", "Abnormal circulating porphyrin concentration", "Abnormal circulating progesterone level", "Abnormal circulating proline concentration", "Abnormal circulating protein concentration", "Abnormal circulating proteinogenic amino acid concentration", "Abnormal circulating proteinogenic amino acid derivative concentration", "Abnormal circulating pyruvate family amino acid concentration", "Abnormal circulating renin", "Abnormal circulating serine concentration", "Abnormal circulating serine family amino acid concentration", "Abnormal circulating sex hormone concentration", "Abnormal circulating sulfur amino acid concentration", "Abnormal circulating tyrosine concentration", "Abnormal clavicle morphology", "Abnormal cns myelination", "Abnormal cochlea morphology", "Abnormal conjugate eye movement", "Abnormal conjunctiva morphology", "Abnormal connection of the cardiac segments", "Abnormal consumption behavior", "Abnormal conus terminalis morphology", "Abnormal cornea morphology", "Abnormal corneal epithelium morphology", "Abnormal coronary artery morphology", "Abnormal coronary sinus morphology", "Abnormal corpus callosum morphology", "Abnormal corpus striatum morphology", "Abnormal cortical bone morphology", "Abnormal cortical gyration", "Abnormal cranial nerve morphology", "Abnormal cranial nerve physiology", "Abnormal cry", "Abnormal csf carboxylic acid concentration", "Abnormal csf metabolite level", "Abnormal csf protein level", "Abnormal csf pyruvate family amino acid concentration", "Abnormal cutaneous elastic fiber morphology", "Abnormal delayed hypersensitivity skin test", "Abnormal delivery", "Abnormal dense granules", "Abnormal dental pulp morphology", "Abnormal dental root morphology", "Abnormal dentate nucleus morphology", "Abnormal dentin morphology", "Abnormal dermatoglyphics", "Abnormal dermoepidermal junction morphology", "Abnormal diaphysis morphology", "Abnormal distal phalanx morphology of finger", "Abnormal dlco", "Abnormal drinking behavior", "Abnormal duodenum morphology", "Abnormal dura mater morphology", "Abnormal eating behavior", "Abnormal echocardiogram", "Abnormal elasticity of skin", "Abnormal electrophysiology of sinoatrial node origin", "Abnormal electroretinogram", "Abnormal emotion affect behavior", "Abnormal enchondral ossification", "Abnormal endocardium morphology", "Abnormal endocrine physiology", "Abnormal enzyme coenzyme activity", "Abnormal eosinophil morphology", "Abnormal epidermal morphology", "Abnormal epiglottis morphology", "Abnormal epiphyseal ossification", "Abnormal epiphysis morphology of the phalanges of the hand", "Abnormal erythrocyte enzyme level", "Abnormal erythrocyte morphology", "Abnormal erythrocyte physiology", "Abnormal erythrocyte sedimentation rate", "Abnormal esophagus morphology", "Abnormal esophagus physiology", "Abnormal external genitalia", "Abnormal exteroceptive sensation", "Abnormal eyebrow morphology", "Abnormal eyelash morphology", "Abnormal eyelid morphology", "Abnormal eyelid physiology", "Abnormal facial expression", "Abnormal facial shape", "Abnormal factor ix activity", "Abnormal fallopian tube morphology", "Abnormal fear anxiety related behavior", "Abnormal female reproductive system physiology", "Abnormal femoral head morphology", "Abnormal femoral neck head morphology", "Abnormal femoral neck morphology", "Abnormal finger phalanx morphology", "Abnormal fingernail morphology", "Abnormal fingertip morphology", "Abnormal foot bone ossification", "Abnormal foramen magnum morphology", "Abnormal forearm bone morphology", "Abnormal form of the vertebral bodies", "Abnormal foveal morphology", "Abnormal full field electroretinogram", "Abnormal fundus autofluorescence imaging", "Abnormal gallbladder morphology", "Abnormal gastrointestinal motility", "Abnormal glial cell morphology", "Abnormal globus pallidus morphology", "Abnormal glomerular basement membrane morphology", "Abnormal glomerular filtration rate", "Abnormal glomerular mesangial cellularity", "Abnormal glomerular mesangium morphology", "Abnormal glucose homeostasis", "Abnormal glycosylation", "Abnormal granulocyte count", "Abnormal granulocytopoietic cell morphology", "Abnormal greater sciatic notch morphology", "Abnormal growth hormone level", "Abnormal hair laboratory examination", "Abnormal hair morphology", "Abnormal hair pattern", "Abnormal hair quantity", "Abnormal hair whorl", "Abnormal hand bone ossification", "Abnormal hand morphology", "Abnormal hdl cholesterol concentration", "Abnormal head movements", "Abnormal heart rate variability", "Abnormal heart sound", "Abnormal heart valve morphology", "Abnormal heart valve physiology", "Abnormal hemoglobin", "Abnormal hemoglobin concentration", "Abnormal hepatic iron concentration", "Abnormal humerus morphology", "Abnormal hypothalamus morphology", "Abnormal hypothalamus physiology", "Abnormal ileum morphology", "Abnormal iliac wing morphology", "Abnormal ilium morphology", "Abnormal immune system morphology", "Abnormal incisor morphology", "Abnormal inflammatory response", "Abnormal insulin level", "Abnormal internal carotid artery morphology", "Abnormal internal genitalia", "Abnormal intestine morphology", "Abnormal intraocular pressure", "Abnormal involuntary eye movements", "Abnormal iris pigmentation", "Abnormal jaw morphology", "Abnormal jejunum morphology", "Abnormal joint morphology", "Abnormal labia majora morphology", "Abnormal labia minora morphology", "Abnormal labia morphology", "Abnormal lacrimal duct morphology", "Abnormal lacrimal gland morphology", "Abnormal lactate dehydrogenase level", "Abnormal large intestine morphology", "Abnormal large intestine physiology", "Abnormal larynx morphology", "Abnormal larynx physiology", "Abnormal lateral ventricle morphology", "Abnormal ldl cholesterol concentration", "Abnormal left atrium morphology", "Abnormal left ventricle morphology", "Abnormal left ventricular outflow tract morphology", "Abnormal length of corpus callosum", "Abnormal leukocyte count", "Abnormal leukocyte physiology", "Abnormal levels of alpha fetoprotein", "Abnormal libido", "Abnormal light and dark adapted electroretinogram", "Abnormal lip morphology", "Abnormal liver morphology", "Abnormal liver parenchyma morphology", "Abnormal liver physiology", "Abnormal localization of kidney", "Abnormal location of ears", "Abnormal lower limb bone morphology", "Abnormal lower motor neuron morphology", "Abnormal lumbar spine morphology", "Abnormal lung development", "Abnormal lung lobation", "Abnormal lymphatic vessel morphology", "Abnormal lymphocyte morphology", "Abnormal macrophage morphology", "Abnormal macroscopic urine appearance", "Abnormal macular morphology", "Abnormal magnesium concentration", "Abnormal male reproductive system physiology", "Abnormal mandibular ramus morphology", "Abnormal mean corpuscular hemoglobin concentration", "Abnormal mean corpuscular volume", "Abnormal megakaryocyte morphology", "Abnormal meningeal morphology", "Abnormal metabolic brain imaging by mrs", "Abnormal metabolism", "Abnormal metacarpal morphology", "Abnormal metaphyseal trabeculation", "Abnormal metatarsal morphology", "Abnormal midbrain morphology", "Abnormal middle phalanx morphology of the hand", "Abnormal mitochondria in muscle tissue", "Abnormal mitochondrial morphology", "Abnormal mitochondrial number", "Abnormal mitochondrial shape", "Abnormal mitral valve physiology", "Abnormal monocyte morphology", "Abnormal morphology of myocardial trabeculae", "Abnormal morphology of the abdominal musculature", "Abnormal morphology of the choroidal vasculature", "Abnormal morphology of the conjunctival vasculature", "Abnormal morphology of the great vessels", "Abnormal morphology of the limbic system", "Abnormal morphology of the musculature of the neck", "Abnormal morphology of the olfactory bulb", "Abnormal morphology of the radius", "Abnormal motor evoked potentials", "Abnormal motor nerve conduction velocity", "Abnormal muscle fiber alpha dystroglycan", "Abnormal muscle fiber morphology", "Abnormal muscle fiber protein expression", "Abnormal muscle fiber type distribution", "Abnormal muscle glycogen content", "Abnormal myelination", "Abnormal myeloid cell morphology", "Abnormal myeloid leukocyte morphology", "Abnormal myocardium morphology", "Abnormal nasal base", "Abnormal nasal bridge morphology", "Abnormal nasal mucosa morphology", "Abnormal nasolacrimal system morphology", "Abnormal natural killer cell morphology", "Abnormal natural killer cell physiology", "Abnormal nephron morphology", "Abnormal nerve conduction velocity", "Abnormal nervous system electrophysiology", "Abnormal neural tube morphology", "Abnormal neuron morphology", "Abnormal neutrophil count", "Abnormal nipple morphology", "Abnormal number of erythroid precursors", "Abnormal number of granulocyte precursors", "Abnormal number of incisors", "Abnormal number of permanent teeth", "Abnormal number of teeth", "Abnormal odontoid tissue morphology", "Abnormal optical coherence tomography", "Abnormal oral frenulum morphology", "Abnormal oral glucose tolerance", "Abnormal oral mucosa morphology", "Abnormal oral physiology", "Abnormal ossification involving the femoral head and neck", "Abnormal ovarian morphology", "Abnormal ovarian physiology", "Abnormal palate morphology", "Abnormal palmar dermatoglyphics", "Abnormal pancreas morphology", "Abnormal pancreas size", "Abnormal paranasal sinus morphology", "Abnormal parietal bone morphology", "Abnormal parotid gland morphology", "Abnormal patella morphology", "Abnormal pattern of respiration", "Abnormal pelvis bone morphology", "Abnormal pelvis bone ossification", "Abnormal penis morphology", "Abnormal pericardium morphology", "Abnormal peripheral action potential amplitude", "Abnormal peripheral myelination", "Abnormal peripheral nervous system morphology", "Abnormal peripheral nervous system physiology", "Abnormal peristalsis", "Abnormal periventricular white matter morphology", "Abnormal phalangeal joint morphology of the hand", "Abnormal pharynx morphology", "Abnormal pigmentation of the oral mucosa", "Abnormal pineal morphology", "Abnormal placenta morphology", "Abnormal placental membrane morphology", "Abnormal placental size", "Abnormal platelet aggregation", "Abnormal platelet function", "Abnormal platelet granules", "Abnormal platelet morphology", "Abnormal platelet volume", "Abnormal pleura morphology", "Abnormal pons morphology", "Abnormal posterior segment imaging", "Abnormal posturing", "Abnormal pr interval", "Abnormal preputium morphology", "Abnormal prolactin level", "Abnormal proportion of cd4 positive t cells", "Abnormal proportion of cd8 positive t cells", "Abnormal proportion of class switched memory b cells", "Abnormal proportion of double negative alpha beta regulatory t cell", "Abnormal prostate morphology", "Abnormal protein glycosylation", "Abnormal protein o linked glycosylation", "Abnormal proximal phalanx morphology of the hand", "Abnormal pulmonary interstitial morphology", "Abnormal pulmonary thoracic imaging finding", "Abnormal pulmonary valve morphology", "Abnormal pulmonary valve physiology", "Abnormal pulse", "Abnormal pupil morphology", "Abnormal pupillary function", "Abnormal pupillary light reflex", "Abnormal pyramidal sign", "Abnormal qrs complex", "Abnormal qt interval", "Abnormal rectum morphology", "Abnormal reflex", "Abnormal renal collecting system morphology", "Abnormal renal cortex morphology", "Abnormal renal corticomedullary differentiation", "Abnormal renal echogenicity", "Abnormal renal insterstitial morphology", "Abnormal renal medulla morphology", "Abnormal renal morphology", "Abnormal renal pelvis morphology", "Abnormal renal physiology", "Abnormal renal resorption", "Abnormal renal tubule morphology", "Abnormal renal vascular morphology", "Abnormal respiratory motile cilium morphology", "Abnormal respiratory motile cilium physiology", "Abnormal respiratory system morphology", "Abnormal response to acth stimulation test", "Abnormal response to endocrine stimulation test", "Abnormal response to insulin tolerance test", "Abnormal reticulocyte morphology", "Abnormal retinal artery morphology", "Abnormal retinal morphology", "Abnormal retinal vascular morphology", "Abnormal rib cage morphology", "Abnormal rib ossification", "Abnormal right atrium morphology", "Abnormal right ventricle morphology", "Abnormal saccadic eye movements", "Abnormal sacroiliac joint morphology", "Abnormal sacrum morphology", "Abnormal salivary gland morphology", "Abnormal sarcomere morphology", "Abnormal scalp morphology", "Abnormal scapula morphology", "Abnormal sclera morphology", "Abnormal scrotal rugation", "Abnormal sella turcica morphology", "Abnormal sensory nerve conduction velocity", "Abnormal serum insulin like growth factor 1 level", "Abnormal serum interferon level", "Abnormal serum interleukin level", "Abnormal serum iron concentration", "Abnormal sex determination", "Abnormal shape of the frontal region", "Abnormal shape of the occiput", "Abnormal shape of the palpebral fissure", "Abnormal sharpey fiber morphology", "Abnormal shoulder morphology", "Abnormal shoulder physiology", "Abnormal size of pituitary gland", "Abnormal size of the clitoris", "Abnormal size of the palpebral fissures", "Abnormal skin morphology of the palm", "Abnormal social behavior", "Abnormal soft palate morphology", "Abnormal speech prosody", "Abnormal sperm motility", "Abnormal spermatogenesis", "Abnormal spinal meningeal morphology", "Abnormal sputum", "Abnormal st segment", "Abnormal sternal ossification", "Abnormal sternum morphology", "Abnormal stomach morphology", "Abnormal stool composition", "Abnormal subarachnoid space morphology", "Abnormal subclavian artery morphology", "Abnormal subcutaneous fat tissue distribution", "Abnormal substantia nigra morphology", "Abnormal superior cerebellar peduncle morphology", "Abnormal sweat gland morphology", "Abnormal sweat homeostasis", "Abnormal synaptic transmission at the neuromuscular junction", "Abnormal systemic arterial morphology", "Abnormal systemic blood pressure", "Abnormal t cell activation", "Abnormal t cell morphology", "Abnormal t cell proliferation", "Abnormal t cell subset distribution", "Abnormal t wave", "Abnormal talus morphology", "Abnormal temper tantrums", "Abnormal temporal bone morphology", "Abnormal tendon morphology", "Abnormal testis morphology", "Abnormal thalamic mri signal intensity", "Abnormal thalamic size", "Abnormal thoracic spine morphology", "Abnormal thorax morphology", "Abnormal thrombocyte morphology", "Abnormal thrombosis", "Abnormal thumb morphology", "Abnormal thyroid hormone level", "Abnormal thyroid morphology", "Abnormal thyroid stimulating hormone level", "Abnormal tissue metabolite concentration", "Abnormal toenail morphology", "Abnormal tongue morphology", "Abnormal tongue physiology", "Abnormal trabecular bone morphology", "Abnormal tracheal morphology", "Abnormal tracheobronchial morphology", "Abnormal transferrin saturation", "Abnormal tricuspid valve morphology", "Abnormal tricuspid valve physiology", "Abnormal umbilicus morphology", "Abnormal upper limb bone morphology", "Abnormal upper motor neuron morphology", "Abnormal ureter morphology", "Abnormal ureter physiology", "Abnormal urinary color", "Abnormal urinary electrolyte concentration", "Abnormal urine alpha ketoglutarate concentration", "Abnormal urine carbohydrate level", "Abnormal urine carboxylic acid level", "Abnormal urine cytology", "Abnormal urine hormone level", "Abnormal urine magnesium concentration", "Abnormal urine metabolite level", "Abnormal urine ph", "Abnormal urine phosphate concentration", "Abnormal urine potassium concentration", "Abnormal urine protein level", "Abnormal urine sodium concentration", "Abnormal uterus morphology", "Abnormal uvea morphology", "Abnormal uvula morphology", "Abnormal vagina morphology", "Abnormal vascular morphology", "Abnormal vascular physiology", "Abnormal vena cava morphology", "Abnormal venous morphology", "Abnormal ventricular septum morphology", "Abnormal vertebral morphology", "Abnormal vertebral segmentation and fusion", "Abnormal vestibulo ocular reflex", "Abnormal visual electrophysiology", "Abnormal visual field test", "Abnormal visual fixation", "Abnormal vitamin b12 level", "Abnormal vitreous humor morphology", "Abnormal waist to hip ratio", "Abnormal z disc morphology", "Abnormalities of placenta or umbilical cord", "Abnormality iris morphology", "Abnormality of abdominal situs", "Abnormality of acid base homeostasis", "Abnormality of adrenal morphology", "Abnormality of adrenal physiology", "Abnormality of alkaline phosphatase level", "Abnormality of amino acid metabolism", "Abnormality of bladder morphology", "Abnormality of blood circulation", "Abnormality of blood volume homeostasis", "Abnormality of body mass index", "Abnormality of bone marrow cell morphology", "Abnormality of bone mineral density", "Abnormality of canine", "Abnormality of cardiovascular system electrophysiology", "Abnormality of carpal bone ossification", "Abnormality of cartilage of external ear", "Abnormality of central nervous system electrophysiology", "Abnormality of chorioretinal pigmentation", "Abnormality of chromosome segregation", "Abnormality of chromosome stability", "Abnormality of circulating adrenocorticotropin level", "Abnormality of circulating enzyme level", "Abnormality of circulating fibrinogen", "Abnormality of circulating glucocorticoid level", "Abnormality of circulating leptin level", "Abnormality of coagulation", "Abnormality of complement system", "Abnormality of coordination", "Abnormality of corneal size", "Abnormality of corneal stroma", "Abnormality of corneal thickness", "Abnormality of cranial sutures", "Abnormality of dental color", "Abnormality of dental eruption", "Abnormality of dental morphology", "Abnormality of dental structure", "Abnormality of dermal melanosomes", "Abnormality of digestive system morphology", "Abnormality of dna repair", "Abnormality of earlobe", "Abnormality of endocrine pancreas physiology", "Abnormality of epiphysis morphology", "Abnormality of exocrine pancreas physiology", "Abnormality of extrapyramidal motor function", "Abnormality of facial adipose tissue", "Abnormality of facial musculature", "Abnormality of facial skeleton", "Abnormality of facial soft tissue", "Abnormality of female external genitalia", "Abnormality of femur morphology", "Abnormality of fibula morphology", "Abnormality of finger", "Abnormality of fluid regulation", "Abnormality of folate metabolism", "Abnormality of fontanelles", "Abnormality of foveal pigmentation", "Abnormality of frontal sinus", "Abnormality of frontalis muscle belly", "Abnormality of fundus pigmentation", "Abnormality of globe location", "Abnormality of globe size", "Abnormality of glycolipid metabolism", "Abnormality of hair growth", "Abnormality of hair pigmentation", "Abnormality of hair texture", "Abnormality of hand joint mobility", "Abnormality of head blood vessel", "Abnormality of hepatobiliary system physiology", "Abnormality of hindbrain morphology", "Abnormality of humoral immunity", "Abnormality of immune serum protein physiology", "Abnormality of iron homeostasis", "Abnormality of krebs cycle metabolism", "Abnormality of lens shape", "Abnormality of limb epiphysis morphology", "Abnormality of lipoprotein cholesterol concentration", "Abnormality of long bone morphology", "Abnormality of lower limb epiphysis morphology", "Abnormality of lower limb joint", "Abnormality of lower limb metaphyses", "Abnormality of lower lip", "Abnormality of lysosomal metabolism", "Abnormality of macular pigmentation", "Abnormality of malar bones", "Abnormality of male internal genitalia", "Abnormality of masticatory muscle", "Abnormality of metacarpal epiphyses", "Abnormality of metacarpophalangeal joint", "Abnormality of mouth shape", "Abnormality of mouth size", "Abnormality of muscle size", "Abnormality of nail color", "Abnormality of neuronal migration", "Abnormality of neutrophil morphology", "Abnormality of neutrophil physiology", "Abnormality of neutrophils", "Abnormality of ocular smooth pursuit", "Abnormality of olfactory lobe morphology", "Abnormality of pain sensation", "Abnormality of pancreas physiology", "Abnormality of pelvic girdle bone morphology", "Abnormality of periauricular region", "Abnormality of peripheral nerves", "Abnormality of prenatal development or birth", "Abnormality of primary teeth", "Abnormality of prothrombin", "Abnormality of pulmonary circulation", "Abnormality of refraction", "Abnormality of renal excretion", "Abnormality of renin angiotensin system", "Abnormality of reproductive system physiology", "Abnormality of retinal pigmentation", "Abnormality of salivation", "Abnormality of secondary sexual hair", "Abnormality of skeletal maturation", "Abnormality of skeletal muscle fiber size", "Abnormality of skin adnexa physiology", "Abnormality of skin physiology", "Abnormality of skin pigmentation", "Abnormality of skull ossification", "Abnormality of small intestinal villus morphology", "Abnormality of somatosensory evoked potentials", "Abnormality of subcutaneous fat tissue", "Abnormality of t cell physiology", "Abnormality of taste sensation", "Abnormality of temperature regulation", "Abnormality of thalamus morphology", "Abnormality of the 1st metacarpal", "Abnormality of the 2nd toe", "Abnormality of the 3rd toe", "Abnormality of the 4th metacarpal", "Abnormality of the 5th metacarpal", "Abnormality of the 5th toe", "Abnormality of the abdominal organs", "Abnormality of the abdominal wall", "Abnormality of the achilles tendon", "Abnormality of the adrenal glands", "Abnormality of the alveolar ridges", "Abnormality of the amniotic fluid", "Abnormality of the ankles", "Abnormality of the anterior fontanelle", "Abnormality of the antihelix", "Abnormality of the antitragus", "Abnormality of the anus", "Abnormality of the auditory canal", "Abnormality of the autonomic nervous system", "Abnormality of the axillary hair", "Abnormality of the basal ganglia", "Abnormality of the biliary system", "Abnormality of the bladder", "Abnormality of the brainstem white matter", "Abnormality of the breast", "Abnormality of the calcaneus", "Abnormality of the calf", "Abnormality of the calf musculature", "Abnormality of the calvaria", "Abnormality of the carpal bones", "Abnormality of the cerebral subcortex", "Abnormality of the cerebrospinal fluid", "Abnormality of the cervical spine", "Abnormality of the cheek", "Abnormality of the chin", "Abnormality of the choanae", "Abnormality of the clitoris", "Abnormality of the coagulation cascade", "Abnormality of the columella", "Abnormality of the common coagulation pathway", "Abnormality of the costochondral junction", "Abnormality of the crus of the helix", "Abnormality of the curvature of the cornea", "Abnormality of the curvature of the vertebral column", "Abnormality of the dentition", "Abnormality of the diaphragm", "Abnormality of the diencephalon", "Abnormality of the distal phalanges of the toes", "Abnormality of the distal phalanx of the thumb", "Abnormality of the dorsal column of the spinal cord", "Abnormality of the elbow", "Abnormality of the endometrium", "Abnormality of the epididymis", "Abnormality of the epiphyses of the distal phalanx of finger", "Abnormality of the eustachian tube", "Abnormality of the external nose", "Abnormality of the extraocular muscles", "Abnormality of the extrinsic pathway", "Abnormality of the female genitalia", "Abnormality of the fetal cardiovascular system", "Abnormality of the fifth metatarsal bone", "Abnormality of the fontanelles or cranial sutures", "Abnormality of the foot musculature", "Abnormality of the forearm", "Abnormality of the forehead", "Abnormality of the frontal hairline", "Abnormality of the gallbladder", "Abnormality of the gastric mucosa", "Abnormality of the gingiva", "Abnormality of the glabella", "Abnormality of the glenoid fossa", "Abnormality of the hairline", "Abnormality of the hallux", "Abnormality of the helix", "Abnormality of the hepatic vasculature", "Abnormality of the humeroradial joint", "Abnormality of the humerus", "Abnormality of the hypothalamus pituitary axis", "Abnormality of the hypothenar eminence", "Abnormality of the incisor", "Abnormality of the inner ear", "Abnormality of the internal auditory canal", "Abnormality of the intervertebral disk", "Abnormality of the intrahepatic bile duct", "Abnormality of the intrinsic pathway", "Abnormality of the ischium", "Abnormality of the kidney", "Abnormality of the knee", "Abnormality of the larynx", "Abnormality of the lens", "Abnormality of the leydig cells", "Abnormality of the liver", "Abnormality of the lower urinary tract", "Abnormality of the lymph nodes", "Abnormality of the lymphatic system", "Abnormality of the mastoid", "Abnormality of the maxilla", "Abnormality of the menstrual cycle", "Abnormality of the metacarpal bones", "Abnormality of the metaphysis", "Abnormality of the metopic suture", "Abnormality of the middle ear", "Abnormality of the middle ear ossicles", "Abnormality of the middle phalanges of the toes", "Abnormality of the middle phalanx of the 5th finger", "Abnormality of the midface", "Abnormality of the mitochondrion", "Abnormality of the musculature of the hand", "Abnormality of the musculature of the limbs", "Abnormality of the musculature of the lower limbs", "Abnormality of the musculature of the thigh", "Abnormality of the musculature of the upper arm", "Abnormality of the musculature of the upper limbs", "Abnormality of the nail", "Abnormality of the nasal alae", "Abnormality of the nasal bone", "Abnormality of the nasal cavity", "Abnormality of the nasal dorsum", "Abnormality of the nasal septum", "Abnormality of the nasal skeleton", "Abnormality of the nasal tip", "Abnormality of the nasolabial region", "Abnormality of the neck", "Abnormality of the odontoid process", "Abnormality of the optic nerve", "Abnormality of the outer ear", "Abnormality of the ovary", "Abnormality of the palm", "Abnormality of the palpebral fissures", "Abnormality of the pancreas", "Abnormality of the parathyroid gland", "Abnormality of the parathyroid morphology", "Abnormality of the periorbital region", "Abnormality of the peripheral nervous system", "Abnormality of the peritoneum", "Abnormality of the periungual region", "Abnormality of the phalanges of the hallux", "Abnormality of the phalanges of the toes", "Abnormality of the pharynx", "Abnormality of the philtrum", "Abnormality of the pineal gland", "Abnormality of the pinna", "Abnormality of the pituitary gland", "Abnormality of the plantar skin of foot", "Abnormality of the posterior pituitary", "Abnormality of the protein c anticoagulant pathway", "Abnormality of the proximal phalanx of the thumb", "Abnormality of the pubic bone", "Abnormality of the pubic hair", "Abnormality of the pulmonary artery", "Abnormality of the pulmonary vasculature", "Abnormality of the pulmonary veins", "Abnormality of the pylorus", "Abnormality of the radial head", "Abnormality of the radioulnar joints", "Abnormality of the ribs", "Abnormality of the scrotum", "Abnormality of the sense of smell", "Abnormality of the septum pellucidum", "Abnormality of the shoulder girdle musculature", "Abnormality of the skull base", "Abnormality of the small intestine", "Abnormality of the spinal cord", "Abnormality of the spinocerebellar tracts", "Abnormality of the spleen", "Abnormality of the stapes", "Abnormality of the subungual region", "Abnormality of the supraorbital ridges", "Abnormality of the synovia", "Abnormality of the tarsal bones", "Abnormality of the temporomandibular joint", "Abnormality of the testis size", "Abnormality of the thenar eminence", "Abnormality of the thoracic cavity", "Abnormality of the thymus", "Abnormality of the thyroid gland", "Abnormality of the tongue", "Abnormality of the tongue muscle", "Abnormality of the tonsils", "Abnormality of the tragus", "Abnormality of the ulna", "Abnormality of the umbilical cord", "Abnormality of the upper arm", "Abnormality of the upper respiratory tract", "Abnormality of the ureter", "Abnormality of the urethra", "Abnormality of the urinary system physiology", "Abnormality of the uterus", "Abnormality of the vasculature of the eye", "Abnormality of the vertebral endplates", "Abnormality of the vestibulocochlear nerve", "Abnormality of the voice", "Abnormality of the wrist", "Abnormality of the zygomatic bone", "Abnormality of thyroid physiology", "Abnormality of tibia morphology", "Abnormality of toe", "Abnormality of ulnar metaphysis", "Abnormality of upper limb epiphysis morphology", "Abnormality of upper limb joint", "Abnormality of upper limb metaphysis", "Abnormality of upper lip", "Abnormality of upper lip vermillion", "Abnormality of urinary uric acid concentration", "Abnormality of urine calcium concentration", "Abnormality of urine catecholamine concentration", "Abnormality of urine homeostasis", "Abnormality of visual evoked potentials", "Abnormality of vitamin a metabolism", "Abnormality of vitamin b metabolism", "Abnormality of vitamin b12 metabolism", "Abnormality of vitamin d metabolism", "Abnormality of vitamin e metabolism", "Abnormality of vitamin k metabolism", "Abnormality of vitamin metabolism", "Abnormality on pulmonary function testing", "Abnormally folded helix", "Abnormally large globe", "Abnormally lax or hyperextensible skin", "Abnormally low pitched voice", "Abnormally ossified vertebrae", "Abnormally shaped carpal bones", "Abscess", "Absence of pubertal development", "Absence of secondary sex characteristics", "Absence of subcutaneous fat", "Absence of the sacrum", "Absent axillary hair", "Absent brainstem auditory responses", "Absent distal phalanges", "Absent earlobe", "Absent epiphyses", "Absent eyebrow", "Absent facial hair", "Absent fingernail", "Absent forearm bone", "Absent foveal reflex", "Absent frontal sinuses", "Absent hair", "Absent hand", "Absent hypoplastic paranasal sinuses", "Absent nares", "Absent nipple", "Absent or minimally ossified vertebral bodies", "Absent outer dynein arms", "Absent palmar crease", "Absent septum pellucidum", "Absent shortened dynein arms", "Absent speech", "Absent testis", "Absent thumb", "Absent thumbnail", "Absent tibia", "Absent toe", "Absent toenail", "Acanthocytosis", "Acantholysis", "Acanthosis nigricans", "Accelerated atherosclerosis", "Accelerated skeletal maturation", "Accessory oral frenulum", "Accessory spleen", "Acetabular dysplasia", "Acetabular spurs", "Achilles tendon contracture", "Achromatopsia", "Acidemia", "Acne", "Acne inversa", "Acquired abnormal hair pattern", "Acral blistering", "Acral ulceration", "Acromesomelia", "Acroparesthesia", "Action tremor", "Acute coronary syndrome", "Acute encephalopathy", "Acute hepatic failure", "Acute kidney injury", "Acute leukemia", "Acute lymphoblastic leukemia", "Acute myeloid leukemia", "Acute pancreatitis", "Acute phase response", "Addictive behavior", "Adducted thumb", "Adenocarcinoma of the colon", "Adenocarcinoma of the intestines", "Adenocarcinoma of the small intestine", "Adenoma sebaceum", "Adenomatous colonic polyposis", "Adipose tissue loss", "Adrenal hyperplasia", "Adrenal hypoplasia", "Adrenal insufficiency", "Adrenal overactivity", "Adrenocortical abnormality", "Adrenocortical adenoma", "Adrenocortical carcinoma", "Adrenocorticotropic hormone deficiency", "Adrenocorticotropic hormone excess", "Adrenocorticotropin deficient adrenal insufficiency", "Adult onset", "Advanced eruption of teeth", "Advanced ossification of carpal bones", "Agammaglobulinemia", "Aganglionic megacolon", "Agenesis of central incisor", "Agenesis of cerebellar vermis", "Agenesis of corpus callosum", "Agenesis of incisor", "Agenesis of lateral incisor", "Agenesis of maxillary incisor", "Agenesis of permanent teeth", "Aggressive behavior", "Agitation", "Agnosia", "Agyria", "Airway obstruction", "Akinesia", "Alacrima", "Albinism", "Albuminuria", "Alexia", "Alkalosis", "Allergic rhinitis", "Allergy", "Alopecia", "Alopecia of scalp", "Alopecia totalis", "Alopecia universalis", "Alternating esotropia", "Alveolar cell carcinoma", "Alveolar rhabdomyosarcoma", "Alveolar ridge overgrowth", "Amaurosis fugax", "Ambiguous genitalia", "Ambiguous genitalia female", "Ambiguous genitalia male", "Amblyopia", "Amegakaryocytic thrombocytopenia", "Amelogenesis imperfecta", "Amenorrhea", "Aminoaciduria", "Amniotic constriction ring", "Amyloidosis", "Amyotrophic lateral sclerosis", "Anal atresia", "Anal stenosis", "Anarthria", "Anasarca", "Anemia of inadequate production", "Anemic pallor", "Anencephaly", "Angina pectoris", "Angioedema", "Angiofibromas", "Angioid streaks of the fundus", "Angiokeratoma", "Angular cheilitis", "Anhidrosis", "Aniridia", "Anisocoria", "Anisocytosis", "Anisopoikilocytosis", "Anisospondyly", "Ankle clonus", "Ankle flexion contracture", "Ankle weakness", "Ankyloblepharon", "Ankyloglossia", "Ankylosis", "Annular pancreas", "Anodontia", "Anomalous trichromacy", "Anomic aphasia", "Anonychia", "Anophthalmia", "Anorectal anomaly", "Anorexia", "Anosmia", "Anotia", "Antenatal onset", "Anterior open bite malocclusion", "Anterior pituitary dysgenesis", "Anterior plagiocephaly", "Anterior rib cupping", "Anterior uveitis", "Anteriorly placed anus", "Anteverted ears", "Anti thyroid peroxidase antibody positivity", "Antineutrophil antibody positivity", "Antinuclear antibody positivity", "Antiphospholipid antibody positivity", "Aortic aneurysm", "Aortic arch aneurysm", "Aortic atherosclerotic lesion", "Aortic dissection", "Aortic regurgitation", "Aortic root aneurysm", "Aortic valve calcification", "Aortic valve stenosis", "Aphasia", "Aphthous ulcer", "Aplasia cutis congenita", "Aplasia cutis congenita of scalp", "Aplasia cutis congenita on trunk or limbs", "Aplasia cutis congenita over the scalp vertex", "Aplasia hypoplasia affecting bones of the axial skeleton", "Aplasia hypoplasia affecting the anterior segment of the eye", "Aplasia hypoplasia affecting the eye", "Aplasia hypoplasia affecting the fundus", "Aplasia hypoplasia involving bones of the feet", "Aplasia hypoplasia involving bones of the lower limbs", "Aplasia hypoplasia involving bones of the thorax", "Aplasia hypoplasia involving bones of the upper limbs", "Aplasia hypoplasia involving forearm bones", "Aplasia hypoplasia involving the carpal bones", "Aplasia hypoplasia involving the femoral head and neck", "Aplasia hypoplasia involving the metacarpal bones", "Aplasia hypoplasia involving the musculature of the upper limbs", "Aplasia hypoplasia involving the nose", "Aplasia hypoplasia involving the pelvis", "Aplasia hypoplasia involving the sinuses", "Aplasia hypoplasia involving the skeletal musculature", "Aplasia hypoplasia involving the skeleton", "Aplasia hypoplasia involving the vertebral column", "Aplasia hypoplasia of fingers", "Aplasia hypoplasia of metatarsal bones", "Aplasia hypoplasia of the 4th metacarpal", "Aplasia hypoplasia of the 5th finger", "Aplasia hypoplasia of the 5th metacarpal", "Aplasia hypoplasia of the abdominal wall musculature", "Aplasia hypoplasia of the bladder", "Aplasia hypoplasia of the breasts", "Aplasia hypoplasia of the capital femoral epiphysis", "Aplasia hypoplasia of the cerebellar vermis", "Aplasia hypoplasia of the cerebellum", "Aplasia hypoplasia of the cerebral white matter", "Aplasia hypoplasia of the clavicles", "Aplasia hypoplasia of the colon", "Aplasia hypoplasia of the distal phalanges of the hand", "Aplasia hypoplasia of the distal phalanx of the thumb", "Aplasia hypoplasia of the ear", "Aplasia hypoplasia of the earlobes", "Aplasia hypoplasia of the epiglottis", "Aplasia hypoplasia of the extremities", "Aplasia hypoplasia of the eyebrow", "Aplasia hypoplasia of the eyelid", "Aplasia hypoplasia of the femur", "Aplasia hypoplasia of the fibula", "Aplasia hypoplasia of the gallbladder", "Aplasia hypoplasia of the hallux", "Aplasia hypoplasia of the humerus", "Aplasia hypoplasia of the lungs", "Aplasia hypoplasia of the middle phalanges of the toes", "Aplasia hypoplasia of the nails", "Aplasia hypoplasia of the nasal bone", "Aplasia hypoplasia of the nasal septum", "Aplasia hypoplasia of the nipples", "Aplasia hypoplasia of the optic nerve", "Aplasia hypoplasia of the ovary", "Aplasia hypoplasia of the palmar creases", "Aplasia hypoplasia of the patella", "Aplasia hypoplasia of the phalanges of the hand", "Aplasia hypoplasia of the phalanges of the thumb", "Aplasia hypoplasia of the phalanges of the toes", "Aplasia hypoplasia of the proximal phalanges of the hand", "Aplasia hypoplasia of the pubic bone", "Aplasia hypoplasia of the radius", "Aplasia hypoplasia of the retina", "Aplasia hypoplasia of the ribs", "Aplasia hypoplasia of the sacrum", "Aplasia hypoplasia of the scapulae", "Aplasia hypoplasia of the skin", "Aplasia hypoplasia of the spleen", "Aplasia hypoplasia of the sternum", "Aplasia hypoplasia of the thumb", "Aplasia hypoplasia of the thymus", "Aplasia hypoplasia of the thyroid gland", "Aplasia hypoplasia of the tibia", "Aplasia hypoplasia of the tongue", "Aplasia hypoplasia of the tragus", "Aplasia hypoplasia of the ulna", "Aplasia hypoplasia of the uterus", "Aplasia hypoplasia of the uvula", "Aplasia hypoplasia of the vagina", "Aplasia hypoplasia of toe", "Aplasia involving bones of the extremities", "Aplasia involving bones of the lower limbs", "Aplasia of metacarpal bones", "Aplasia of the fingers", "Aplasia of the middle phalanx of the hand", "Aplasia of the phalanges of the hand", "Aplasia of the phalanges of the toes", "Aplasia of the proximal phalanges of the hand", "Aplasia of the semicircular canal", "Aplasia of the uterus", "Aplastic anemia", "Aplastic clavicle", "Aplastic hypoplastic lacrimal glands", "Aplastic hypoplastic toenail", "Apnea", "Apneic episodes in infancy", "Apneic episodes precipitated by illness fatigue stress", "Appendicular hypotonia", "Apraxia", "Aqueductal stenosis", "Arachnodactyly", "Arachnoid hemangiomatosis", "Areflexia", "Areflexia of lower limbs", "Arm dystonia", "Arnold chiari malformation", "Arnold chiari type i malformation", "Arrhinencephaly", "Arteria lusoria", "Arterial dissection", "Arterial rupture", "Arterial stenosis", "Arterial thrombosis", "Arteriosclerosis", "Arteriovenous fistula", "Arteriovenous malformation", "Arthralgia", "Arthritis", "Arthrogryposis multiplex congenita", "Arthropathy", "Ascending aortic dissection", "Ascending tubular aorta aneurysm", "Ascites", "Aspiration", "Aspiration pneumonia", "Asterixis", "Asthenia", "Asthma", "Astigmatism", "Astrocytoma", "Astrocytosis", "Asymmetric growth", "Asymmetric septal hypertrophy", "Asymmetry of spinal facet joints", "Asymmetry of the ears", "Asymmetry of the thorax", "Atelectasis", "Athetosis", "Atlantoaxial abnormality", "Atlantoaxial dislocation", "Atlantoaxial instability", "Atonic seizure", "Atopic dermatitis", "Atresia of the external auditory canal", "Atrial arrhythmia", "Atrial flutter", "Atrioventricular canal defect", "Atrophic scars", "Atrophy degeneration affecting the brainstem", "Atrophy degeneration affecting the central nervous system", "Atrophy degeneration affecting the cerebrum", "Atrophy degeneration involving the caudate nucleus", "Atrophy degeneration involving the corticospinal tracts", "Atrophy degeneration involving the spinal cord", "Atrophy of alveolar ridges", "Attention deficit hyperactivity disorder", "Attenuation of retinal blood vessels", "Atypical absence seizure", "Auditory hallucinations", "Autism", "Autistic behavior", "Autoamputation", "Autoamputation of digits", "Autoimmune antibody positivity", "Autoimmune hemolytic anemia", "Autoimmune thrombocytopenia", "Autoimmunity", "Autophagic vacuoles", "Autosomal dominant germline de novo mutation", "Avascular necrosis", "Avascular necrosis of the capital femoral epiphysis", "Axial dystonia", "Axial muscle weakness", "Axillary pterygium", "Axonal degeneration", "Axonal degeneration regeneration", "Axonal loss", "Axonal regeneration", "Azoospermia", "B cell lymphoma", "B lymphocytopenia", "Babinski sign", "Back pain", "Bacterial endocarditis", "Barrel shaped chest", "Barrett esophagus", "Basal cell carcinoma", "Basal ganglia calcification", "Basal ganglia cysts", "Basal ganglia gliosis", "Basilar invagination", "Beaded ribs", "Beaking of vertebral bodies", "Bell shaped thorax", "Benign neoplasm of the central nervous system", "Bicarbonate wasting renal tubular acidosis", "Bicarbonaturia", "Biconcave vertebral bodies", "Bicornuate uterus", "Bifid epiglottis", "Bifid nasal tip", "Bifid nose", "Bifid ribs", "Bifid scrotum", "Bifid tongue", "Bifid uterus", "Bifid uvula", "Bilateral camptodactyly", "Bilateral cleft lip", "Bilateral cleft lip and palate", "Bilateral cleft palate", "Bilateral coxa valga", "Bilateral cryptorchidism", "Bilateral external ear deformity", "Bilateral microphthalmos", "Bilateral polymicrogyria", "Bilateral ptosis", "Bilateral sensorineural hearing impairment", "Bilateral single transverse palmar creases", "Bilateral talipes equinovarus", "Bilateral tonic clonic seizure", "Bilateral tonic clonic seizure with focal onset", "Bilateral tonic clonic seizure with generalized onset", "Bile duct proliferation", "Biliary atresia", "Biliary cirrhosis", "Biliary tract abnormality", "Biliary tract neoplasm", "Bimanual synkinesia", "Biparietal narrowing", "Bird like facies", "Birth length greater than 97th percentile", "Birth length less than 3rd percentile", "Biventricular hypertrophy", "Bladder diverticulum", "Bladder neoplasm", "Bleeding with minor or no trauma", "Blepharitis", "Blepharophimosis", "Blindness", "Blistering by anatomical location", "Blistering by histological location", "Bloodstream infectious agent", "Bloody diarrhea", "Blue irides", "Blue nevus", "Blue sclerae", "Blurred vision", "Bone cyst", "Bone fracture", "Bone marrow foam cells", "Bone marrow hypercellularity", "Bone marrow hypocellularity", "Bone pain", "Bone spicule pigmentation of the retina", "Bowel diverticulosis", "Bowing of the arm", "Bowing of the legs", "Brachycephaly", "Brachydactyly", "Brachyturricephaly", "Bradycardia", "Bradykinesia", "Brain imaging abnormality", "Brain neoplasm", "Brain stem compression", "Branchial anomaly", "Branchial cyst", "Branchial fistula", "Breast aplasia", "Breast carcinoma", "Breast hypoplasia", "Breathing dysregulation", "Breech presentation", "Brisk reflexes", "Brittle hair", "Broad alveolar ridges", "Broad based gait", "Broad chin", "Broad clavicles", "Broad columella", "Broad distal phalanx of finger", "Broad eyebrow", "Broad face", "Broad femoral neck", "Broad finger", "Broad foot", "Broad forehead", "Broad hallux phalanx", "Broad jaw", "Broad long bones", "Broad metacarpals", "Broad nail", "Broad nasal tip", "Broad neck", "Broad palm", "Broad phalanx of the toes", "Broad philtrum", "Broad ribs", "Broad thumb", "Broad toe", "Bronchiectasis", "Bronchitis", "Bronchomalacia", "Bronchospasm", "Bruising susceptibility", "Brushfield spots", "Bruxism", "Bulbar palsy", "Bulbar signs", "Bulbous nose", "Bull s eye maculopathy", "Bundle branch block", "Buphthalmos", "Burkitt lymphoma", "Butterfly vertebrae", "Cachexia", "Caesarian section", "Cafe au lait spot", "Calcific stippling", "Calcification of the aorta", "Calcinosis", "Calcium nephrolithiasis", "Calcium oxalate nephrolithiasis", "Calf muscle pseudohypertrophy", "Calvarial hyperostosis", "Calvarial osteosclerosis", "Calvarial skull defect", "Camptodactyly of toe", "Capillary hemangioma", "Capillary malformation", "Capitate hamate fusion", "Carcinoid tumor", "Carcinoma", "Cardiac arrest", "Cardiac conduction abnormality", "Cardiac diverticulum", "Cardiac rhabdomyoma", "Cardiac shunt", "Cardiac valve calcification", "Cardiomegaly", "Cardiorespiratory arrest", "Cardiovascular calcification", "Carious teeth", "Carpal bone hypoplasia", "Carpal synostosis", "Cataplexy", "Caudate atrophy", "Cavernous hemangioma", "Cavum septum pellucidum", "Celiac disease", "Cellular immunodeficiency", "Cellulitis", "Central adrenal insufficiency", "Central apnea", "Central diabetes insipidus", "Central heterochromia", "Central hypothyroidism", "Central hypoventilation", "Central nervous system cyst", "Central primitive neuroectodermal tumor", "Central scotoma", "Central sleep apnea", "Central y shaped metacarpal", "Centrally nucleated skeletal muscle fibers", "Centrocecal scotoma", "Cerebellar atrophy", "Cerebellar cortical atrophy", "Cerebellar cyst", "Cerebellar dysplasia", "Cerebellar hemorrhage", "Cerebellar hypoplasia", "Cerebellar malformation", "Cerebellar vermis atrophy", "Cerebral arteriovenous malformation", "Cerebral calcification", "Cerebral cortical atrophy", "Cerebral cortical hemiatrophy", "Cerebral dysmyelination", "Cerebral edema", "Cerebral hamartoma", "Cerebral hemorrhage", "Cerebral hypomyelination", "Cerebral hypoplasia", "Cerebral inclusion bodies", "Cerebral palsy", "Cerebral venous thrombosis", "Cerebral visual impairment", "Cerebral white matter atrophy", "Cerebral white matter hypoplasia", "Cervical kyphosis", "Cervical myelopathy", "Cervical ribs", "Cervical spinal canal stenosis", "Cervical spine instability", "Cervical subluxation", "Cessation of head growth", "Cheilitis", "Cherry red spot of the macula", "Chest pain", "Chilblains", "Childhood onset", "Childhood onset sensorineural hearing impairment", "Childhood onset truncal obesity", "Chills", "Chin with horizontal crease", "Choanal stenosis", "Choking episodes", "Cholangiocarcinoma", "Cholangitis", "Cholecystitis", "Cholestasis", "Cholestatic liver disease", "Chondrocalcinosis", "Chondrosarcoma", "Chordee", "Chorea", "Choreoathetosis", "Choriocarcinoma", "Chorioretinal atrophy", "Chorioretinal coloboma", "Chorioretinal degeneration", "Chorioretinal dysplasia", "Chorioretinal dystrophy", "Chorioretinal hypopigmentation", "Choroid plexus carcinoma", "Choroid plexus cyst", "Choroidal melanoma", "Choroidal neovascularization", "Chromosomal breakage induced by crosslinking agents", "Chromosomal breakage induced by ionizing radiation", "Chromosome breakage", "Chronic atrophic gastritis", "Chronic axonal neuropathy", "Chronic bronchitis", "Chronic constipation", "Chronic diarrhea", "Chronic fatigue", "Chronic hemolytic anemia", "Chronic hepatic failure", "Chronic infection", "Chronic kidney disease", "Chronic leukemia", "Chronic lung disease", "Chronic lymphatic leukemia", "Chronic mucocutaneous candidiasis", "Chronic neutropenia", "Chronic noninfectious lymphadenopathy", "Chronic oral candidiasis", "Chronic otitis media", "Chronic pulmonary obstruction", "Chronic rhinitis", "Chronic sinusitis", "Chylothorax", "Cigarette paper scars", "Cirrhosis", "Cleft hard palate", "Cleft lip", "Cleft soft palate", "Cleft upper lip", "Clinodactyly", "Clitoral hypoplasia", "Clonic seizure", "Clonus", "Cloverleaf skull", "Clubbing", "Clubbing of fingers", "Clubbing of toes", "Clumsiness", "Cns demyelination", "Cns hypomyelination", "Coarctation of aorta", "Coarse facial features", "Coarse hair", "Cochlear malformation", "Cognitive impairment", "Cogwheel rigidity", "Cold induced muscle cramps", "Colitis", "Collectionism", "Coloboma", "Colon cancer", "Color vision defect", "Color vision test abnormality", "Colorectal polyposis", "Colpocephaly", "Coma", "Combined immunodeficiency", "Communicating hydrocephalus", "Complete atrioventricular canal defect", "Complete duplication of phalanx of hand", "Complex febrile seizure", "Concave nail", "Concave nasal ridge", "Concentric hypertrophic cardiomyopathy", "Cone cone rod dystrophy", "Cone shaped epiphyses of the phalanges of the hand", "Cone shaped epiphysis", "Confetti like hypopigmented macules", "Confusion", "Congenital adrenal hyperplasia", "Congenital bilateral hip dislocation", "Congenital blindness", "Congenital contracture", "Congenital craniofacial dysostosis", "Congenital diaphragmatic hernia", "Congenital finger flexion contractures", "Congenital hemolytic anemia", "Congenital hepatic fibrosis", "Congenital hip dislocation", "Congenital hypothyroidism", "Congenital ichthyosiform erythroderma", "Congenital localized absence of skin", "Congenital malformation of the great arteries", "Congenital malformation of the left heart", "Congenital malformation of the right heart", "Congenital muscular dystrophy", "Congenital muscular torticollis", "Congenital nonbullous ichthyosiform erythroderma", "Congenital nystagmus", "Congenital onset", "Congenital posterior urethral valve", "Congenital ptosis", "Congenital sensorineural hearing impairment", "Congenital stationary night blindness", "Congenital thrombocytopenia", "Congestive heart failure", "Conical incisor", "Conical tooth", "Conjugated hyperbilirubinemia", "Conjunctival hamartoma", "Connective tissue nevi", "Conspicuously happy disposition", "Constipation", "Constitutional symptom", "Constriction of peripheral visual field", "Contiguous gene syndrome", "Contractures involving the joints of the feet", "Contractures of the joints of the lower limbs", "Contractures of the joints of the upper limbs", "Contractures of the large joints", "Convex nasal ridge", "Coombs positive hemolytic anemia", "Cor pulmonale", "Corneal dystrophy", "Corneal erosion", "Corneal neovascularization", "Corneal opacity", "Corneal scarring", "Corneal ulceration", "Coronal cleft vertebrae", "Coronal craniosynostosis", "Coronary artery atherosclerosis", "Corpus callosum atrophy", "Cortical cataract", "Cortical dysplasia", "Cortical myoclonus", "Cortical thickening of long bone diaphyses", "Corticospinal tract hypoplasia", "Cough", "Coxa valga", "Coxa vara", "Crackles", "Cranial asymmetry", "Cranial hyperostosis", "Cranial nerve compression", "Craniofacial asymmetry", "Craniofacial dysostosis", "Craniofacial hyperostosis", "Craniofacial osteosclerosis", "Craniosynostosis", "Crossed fused renal ectopia", "Crumpled long bones", "Cryptorchidism", "Csf lymphocytic pleiocytosis", "Csf pleocytosis", "Cubitus valgus", "Cupped ear", "Cupped ribs", "Curly eyelashes", "Curly hair", "Cutaneous abscess", "Cutaneous amyloidosis", "Cutaneous cyst", "Cutaneous finger syndactyly", "Cutaneous melanoma", "Cutaneous photosensitivity", "Cutaneous syndactyly", "Cutaneous syndactyly of toes", "Cutis laxa", "Cutis marmorata", "Cyanosis", "Cyanotic episode", "Cyclopia", "Cystic hygroma", "Cystic liver disease", "Cystic renal dysplasia", "Cystinuria", "Cystoid macular edema", "Cytochrome c oxidase negative muscle fibers", "Dark urine", "Death in adolescence", "Death in adulthood", "Death in childhood", "Death in infancy", "Decerebrate rigidity", "Decreased absent ankle reflexes", "Decreased achilles reflex", "Decreased activity of mitochondrial complex i", "Decreased activity of mitochondrial complex ii", "Decreased activity of mitochondrial complex iii", "Decreased activity of mitochondrial complex iv", "Decreased activity of nadph oxidase", "Decreased activity of the pyruvate dehydrogenase complex", "Decreased adenosylcobalamin", "Decreased adipose tissue", "Decreased calvarial ossification", "Decreased cd4 cd8 ratio", "Decreased cervical spine flexion due to contractures of posterior cervical muscles", "Decreased cervical spine mobility", "Decreased circulating acth level", "Decreased circulating aldosterone level", "Decreased circulating androgen concentration", "Decreased circulating antibody level", "Decreased circulating copper concentration", "Decreased circulating cortisol level", "Decreased circulating follicle stimulating hormone concentration", "Decreased circulating gonadotropin concentration", "Decreased circulating iga level", "Decreased circulating igg level", "Decreased circulating igg subclass level", "Decreased circulating level of specific antibody", "Decreased circulating progesterone", "Decreased circulating total iga", "Decreased circulating total igg", "Decreased circulating total igm", "Decreased corneal reflex", "Decreased facial expression", "Decreased fertility", "Decreased fertility in females", "Decreased fertility in males", "Decreased head circumference", "Decreased lacrimation", "Decreased ldl cholesterol concentration", "Decreased libido", "Decreased light and dark adapted electroretinogram amplitude", "Decreased lymphocyte apoptosis", "Decreased lymphocyte proliferation in response to mitogen", "Decreased mean corpuscular volume", "Decreased methylcobalamin", "Decreased methylmalonyl coa mutase activity", "Decreased muscle mass", "Decreased number of large peripheral myelinated nerve fibers", "Decreased number of peripheral myelinated nerve fibers", "Decreased palmar creases", "Decreased patellar reflex", "Decreased plasma carnitine", "Decreased proportion of cd3 positive t cells", "Decreased proportion of cd4 positive helper t cells", "Decreased proportion of cd8 positive t cells", "Decreased pulmonary function", "Decreased serum complement c3", "Decreased serum complement c4", "Decreased serum insulin like growth factor 1", "Decreased serum iron", "Decreased size of nerve terminals", "Decreased specific anti polysaccharide antibody level", "Decreased specific antibody response to protein vaccine", "Decreased specific antibody response to vaccination", "Decreased specific pneumococcal antibody level", "Decreased testicular size", "Decreased urine output", "Deep palmar crease", "Deep philtrum", "Deep plantar creases", "Deep set nails", "Deep venous thrombosis", "Deeply set eye", "Defective dna repair after ultraviolet radiation damage", "Defective t cell proliferation", "Deformed rib cage", "Deformed sella turcica", "Deformed tarsal bones", "Degeneration of the lateral corticospinal tracts", "Degeneration of the striatum", "Dehydration", "Delayed ability to roll over", "Delayed ability to sit", "Delayed ability to stand", "Delayed ability to walk", "Delayed closure of the anterior fontanelle", "Delayed cns myelination", "Delayed cranial suture closure", "Delayed epiphyseal ossification", "Delayed eruption of permanent teeth", "Delayed eruption of primary teeth", "Delayed eruption of teeth", "Delayed fine motor development", "Delayed gross motor development", "Delayed menarche", "Delayed myelination", "Delayed ossification of carpal bones", "Delayed proximal femoral epiphyseal ossification", "Delayed puberty", "Delayed social development", "Delirium", "Delusions", "Dementia", "Demyelinating peripheral neuropathy", "Dental crowding", "Dental malocclusion", "Depletion of mitochondrial dna in muscle tissue", "Deposits immunoreactive to beta amyloid protein", "Depressed nasal bridge", "Depressed nasal ridge", "Depressed nasal tip", "Depression", "Dermal atrophy", "Dermal translucency", "Dermatological manifestations of systemic disorders", "Dermoid cyst", "Descending aortic dissection", "Desquamation of skin soon after birth", "Developmental cataract", "Developmental glaucoma", "Developmental regression", "Developmental stagnation", "Deviated nasal septum", "Deviation of the 2nd finger", "Deviation of the 3rd finger", "Deviation of the hallux", "Deviation of the hand or of fingers of the hand", "Deviation of the thumb", "Deviation of toes", "Diabetes insipidus", "Dialeptic seizure", "Diaphragmatic eventration", "Diaphragmatic paralysis", "Diaphragmatic weakness", "Diaphyseal sclerosis", "Diaphyseal thickening", "Diarrhea", "Diastasis recti", "Diastema", "Dicarboxylic aciduria", "Difficulty climbing stairs", "Difficulty in tongue movements", "Difficulty running", "Difficulty standing", "Difficulty walking", "Diffuse alveolar hemorrhage", "Diffuse cerebellar atrophy", "Diffuse cerebral atrophy", "Diffuse mesangial sclerosis", "Diffuse optic disc pallor", "Diffuse palmoplantar hyperkeratosis", "Diffuse white matter abnormalities", "Digenic inheritance", "Dilatation of the cerebral artery", "Dilatation of the ventricular cavity", "Dilated cardiomyopathy", "Dilated fourth ventricle", "Dilated third ventricle", "Dilation of lateral ventricles", "Dilation of virchow robin spaces", "Diminished ability to concentrate", "Diminished motivation", "Diminished movement", "Dimple chin", "Diplopia", "Disinhibition", "Displacement of the urethral meatus", "Disproportionate short limb short stature", "Disproportionate short stature", "Disproportionate short trunk short stature", "Disproportionate tall stature", "Disseminated intravascular coagulation", "Distal amyotrophy", "Distal arthrogryposis", "Distal joint laxity", "Distal lower limb amyotrophy", "Distal lower limb muscle weakness", "Distal muscle weakness", "Distal peripheral sensory neuropathy", "Distal sensory impairment", "Distal sensory impairment of all modalities", "Distal sensory loss of all modalities", "Distal upper limb amyotrophy", "Distal upper limb muscle weakness", "Disturbance of facial expression", "Dolichocephaly", "Double aortic arch", "Down sloping shoulders", "Downslanted palpebral fissures", "Downturned corners of mouth", "Drowsiness", "Drusen", "Dry hair", "Dry skin", "Duodenal adenocarcinoma", "Duodenal atresia", "Duodenal stenosis", "Duplicated collecting system", "Duplication involving bones of the feet", "Duplication of hand bones", "Duplication of phalanx of hallux", "Duplication of the distal phalanx of hand", "Duplication of thumb phalanx", "Dysarthria", "Dyscalculia", "Dyschromatopsia", "Dysdiadochokinesis", "Dysesthesia", "Dysgammaglobulinemia", "Dysgenesis of the cerebellar vermis", "Dysgerminoma", "Dysgraphia", "Dyskinesia", "Dyslexia", "Dysmenorrhea", "Dysmetria", "Dysmetric saccades", "Dysostosis multiplex", "Dyspareunia", "Dysphagia", "Dysphasia", "Dysphonia", "Dysplasia of the femoral head", "Dysplastic corpus callosum", "Dyspnea", "Dystonia", "Dystrophic fingernails", "Dystrophic toenail", "Dysuria", "Ear pain", "Early onset absence seizures", "Early onset of sexual maturation", "Easy fatigability", "Ecchymosis", "Echolalia", "Eclabion", "Eclampsia", "Ectodermal dysplasia", "Ectopia lentis", "Ectopia pupillae", "Ectopic anus", "Ectopic calcification", "Ectopic kidney", "Ectrodactyly", "Ectropion", "Ectropion of lower eyelids", "Eczema", "Eczematoid dermatitis", "Edema of the dorsum of feet", "Edema of the dorsum of hands", "Eeg with abnormally slow frequencies", "Eeg with burst suppression", "Eeg with continuous slow activity", "Eeg with focal epileptiform discharges", "Eeg with focal sharp slow waves", "Eeg with focal sharp waves", "Eeg with focal spike waves", "Eeg with focal spikes", "Eeg with frontal epileptiform discharges", "Eeg with generalized sharp slow waves", "Eeg with generalized slow activity", "Eeg with irregular generalized spike and wave complexes", "Eeg with multifocal slow activity", "Eeg with polyspike wave complexes", "Eeg with spike wave complexes", "Eeg with spike wave complexes 2 5 3 5 hz", "Elbow ankylosis", "Elbow flexion contracture", "Elevated alkaline phosphatase of bone origin", "Elevated calcitonin", "Elevated circulating alanine aminotransferase concentration", "Elevated circulating aspartate aminotransferase concentration", "Elevated circulating follicle stimulating hormone level", "Elevated circulating glutaric acid concentration", "Elevated circulating growth hormone concentration", "Elevated circulating long chain fatty acid concentration", "Elevated circulating parathyroid hormone level", "Elevated circulating thyroid stimulating hormone concentration", "Elevated creatine kinase after exercise", "Elevated diastolic blood pressure", "Elevated gamma glutamyltransferase level", "Elevated hemoglobin a1c", "Elevated hepatic transaminase", "Elevated lactate pyruvate ratio", "Elevated mean arterial pressure", "Elevated proportion of cd4 negative cd8 negative alpha beta regulatory t cells", "Elevated pulmonary artery pressure", "Elevated serum acid phosphatase", "Elevated systolic blood pressure", "Elevated tissue non specific alkaline phosphatase", "Elevated urinary carboxylic acid", "Elevated urinary delta aminolevulinic acid", "Elevated urinary dicarboxylic acid level", "Elevated urinary monocarboxylic acid level", "Elfin facies", "Elliptocytosis", "Elongated superior cerebellar peduncle", "Embryonal neoplasm", "Embryonal renal neoplasm", "Emg abnormality", "Emg axonal abnormality", "Emg chronic denervation signs", "Emg decremental response of compound muscle action potential to repetitive nerve stimulation", "Emg impaired neuromuscular transmission", "Emg myopathic abnormalities", "Emg neuropathic changes", "Emg slow motor conduction", "Emotional lability", "Emphysema", "Enamel hypoplasia", "Encephalocele", "Encephalopathy", "Enchondroma", "Endocardial fibroelastosis", "Endocardial fibrosis", "Endocarditis", "Enlarged cerebellum", "Enlarged cisterna magna", "Enlarged joints", "Enlarged kidney", "Enlarged metaphyses", "Enlarged ovaries", "Enlarged posterior fossa", "Enlarged thorax", "Enlarged tonsils", "Enlargement of the costochondral junction", "Enlargement of the wrists", "Enterocolitis", "Enthesitis", "Entropion", "Enuresis", "Ependymoma", "Epicanthus", "Epicanthus inversus", "Epidermal acanthosis", "Epidermal hyperkeratosis", "Epidermal nevus", "Epidermoid cyst", "Epigastric pain", "Epileptic aura", "Epileptic encephalopathy", "Epileptic spasm", "Epiphora", "Epiphyseal dysplasia", "Epiphyseal stippling", "Epiretinal membrane", "Episodic ataxia", "Episodic hyperhidrosis", "Episodic hypertension", "Episodic pain", "Episodic respiratory distress", "Episodic tachypnea", "Episodic vomiting", "Epispadias", "Epistaxis", "Equinovarus deformity", "Equinus calcaneus", "Erectile dysfunction", "Erlenmeyer flask deformity of the femurs", "Eruption failure", "Erysipelas", "Erythema", "Erythema nodosum", "Erythematous papule", "Erythematous plaque", "Erythrocyte inclusion bodies", "Erythroderma", "Erythroid hyperplasia", "Erythroid hypoplasia", "Esodeviation", "Esophageal atresia", "Esophageal carcinoma", "Esophageal neoplasm", "Esophageal stenosis", "Esophageal stricture", "Esophageal ulceration", "Esophageal varix", "Esophagitis", "Ethylmalonic aciduria", "Eunuchoid habitus", "Euryblepharon", "Eversion of lateral third of lower eyelids", "Everted upper lip vermilion", "Exaggerated cupid s bow", "Exaggerated startle response", "Excessive daytime somnolence", "Excessive salivation", "Excessive wrinkled skin", "Excessive wrinkling of palmar skin", "Exercise induced muscle cramps", "Exercise induced muscle fatigue", "Exercise induced muscle stiffness", "Exercise induced myalgia", "Exercise induced myoglobinuria", "Exercise induced rhabdomyolysis", "Exercise intolerance", "Exertional dyspnea", "Exodeviation", "Exostoses", "Expressive aphasia", "Expressive language delay", "External ear malformation", "External genital hypoplasia", "External ophthalmoplegia", "Extra axial cerebrospinal fluid accumulation", "Extrahepatic cholestasis", "Extramedullary hematopoiesis", "Extrapyramidal dyskinesia", "Extrapyramidal muscular rigidity", "Exudative retinal detachment", "Eyelid coloboma", "Eyelid myoclonus", "Facial asymmetry", "Facial capillary hemangioma", "Facial cleft", "Facial diplegia", "Facial edema", "Facial erythema", "Facial grimacing", "Facial hemangioma", "Facial hyperostosis", "Facial hypertrichosis", "Facial hypotonia", "Facial myokymia", "Facial shape deformation", "Facial telangiectasia", "Failure of eruption of permanent teeth", "Failure to thrive", "Failure to thrive in infancy", "Fair hair", "Falls", "Fasciculations", "Fasting hyperinsulinemia", "Fasting hypoglycemia", "Fat malabsorption", "Fatigable weakness of bulbar muscles", "Fatigable weakness of distal limb muscles", "Fatigable weakness of respiratory muscles", "Fatigable weakness of skeletal muscles", "Fatigable weakness of swallowing muscles", "Fatiguable weakness of proximal limb muscles", "Fatigue", "Fatty replacement of skeletal muscle", "Feeding difficulties", "Feeding difficulties in infancy", "Female external genitalia in individual with 46 xy karyotype", "Female hypogonadism", "Female infertility", "Female pseudohermaphroditism", "Female reproductive system neoplasm", "Female sexual dysfunction", "Femoral bowing", "Femoral hernia", "Fetal akinesia sequence", "Fetal distress", "Fetal onset", "Fetal polyuria", "Fetal ultrasound soft marker", "Fever", "Fibroadenoma of the breast", "Fibrosarcoma", "Fibrous tissue neoplasm", "Fibular aplasia", "Fibular hypoplasia", "Fine hair", "Finger agnosia", "Finger clinodactyly", "Finger swelling", "Finger syndactyly", "Fingernail dysplasia", "Fingerprint intracellular accumulation of autofluorescent lipopigment storage material", "First degree atrioventricular block", "First dorsal interossei muscle weakness", "Flank pain", "Flared iliac wing", "Flared metaphysis", "Flared nostrils", "Flaring of rib cage", "Flat acetabular roof", "Flat cornea", "Flat face", "Flat forehead", "Flat nasal alae", "Flat occiput", "Flattened epiphysis", "Flattened femoral epiphysis", "Flattened femoral head", "Flexion contracture of digit", "Flexion contracture of thumb", "Fluctuations in consciousness", "Flushing", "Foam cells", "Focal aware seizure", "Focal cortical dysplasia", "Focal cortical dysplasia type ii", "Focal dystonia", "Focal emotional seizure", "Focal impaired awareness seizure", "Focal motor seizure", "Focal motor status epilepticus", "Focal myoclonic seizure", "Focal non motor seizure", "Focal onset seizure", "Focal segmental glomerulosclerosis", "Focal sensory seizure", "Focal t2 hyperintense basal ganglia lesion", "Focal t2 hyperintense brainstem lesion", "Focal tonic seizure", "Focal white matter lesions", "Follicular hyperkeratosis", "Follicular hyperplasia", "Follicular thyroid carcinoma", "Food allergy", "Food intolerance", "Foot acroosteolysis", "Foot dorsiflexor weakness", "Foot oligodactyly", "Fractures of the long bones", "Fragile nails", "Fragile skin", "Fragmented epiphyses", "Freckling", "Frequent falls", "Frontal balding", "Frontal cortical atrophy", "Frontal hirsutism", "Frontal lobe dementia", "Frontotemporal cerebral atrophy", "Frontotemporal dementia", "Full cheeks", "Fulminant hepatic failure", "Functional abnormality of male internal genitalia", "Functional abnormality of the gastrointestinal tract", "Functional abnormality of the inner ear", "Functional abnormality of the middle ear", "Functional intestinal obstruction", "Functional motor deficit", "Furrowed tongue", "Fused cervical vertebrae", "Fusion of the cerebellar hemispheres", "Gait ataxia", "Gait disturbance", "Gait imbalance", "Galactorrhea", "Gangrene", "Gastric ulcer", "Gastritis", "Gastroesophageal reflux", "Gastrointestinal atresia", "Gastrointestinal carcinoma", "Gastrointestinal hemorrhage", "Gastrointestinal infarctions", "Gastrointestinal inflammation", "Gastrointestinal obstruction", "Gastrointestinal stroma tumor", "Gastroparesis", "Gastrostomy tube feeding in infancy", "Gaze evoked nystagmus", "Generalized abnormality of skin", "Generalized aminoaciduria", "Generalized amyotrophy", "Generalized clonic seizure", "Generalized dystonia", "Generalized edema", "Generalized hirsutism", "Generalized hyperkeratosis", "Generalized hyperpigmentation", "Generalized hyperreflexia", "Generalized hypertrichosis", "Generalized hypopigmentation", "Generalized hypopigmentation of hair", "Generalized hypotonia", "Generalized joint laxity", "Generalized limb muscle atrophy", "Generalized lipodystrophy", "Generalized lymphadenopathy", "Generalized muscle weakness", "Generalized myoclonic atonic seizure", "Generalized myoclonic seizure", "Generalized neonatal hypotonia", "Generalized onset motor seizure", "Generalized onset seizure", "Generalized osteoporosis", "Generalized osteosclerosis", "Generalized tonic seizure", "Genetic anticipation", "Genital neoplasm", "Genu valgum", "Genu varum", "Geographic atrophy", "Germ cell neoplasia", "Germinoma", "Giant platelets", "Giant somatosensory evoked potentials", "Gingival bleeding", "Gingival fibromatosis", "Gingival overgrowth", "Gingival recession", "Gingivitis", "Glaucoma", "Glioblastoma multiforme", "Glioma", "Gliosis", "Global brain atrophy", "Glomerular deposits", "Glomerular sclerosis", "Glomerulonephritis", "Glomerulopathy", "Glomus jugular tumor", "Glossitis", "Glossoptosis", "Glucose intolerance", "Glutaric aciduria", "Glycosuria", "Goiter", "Gonadal dysgenesis", "Gonadal neoplasm", "Gonadoblastoma", "Gonosomal inheritance", "Gout", "Gowers sign", "Grammar specific speech disorder", "Granulocytopenia", "Granulomatosis", "Gray matter heterotopia", "Gynecomastia", "Hallucinations", "Hallux valgus", "Hamartoma", "Hamartoma of the eye", "Hamartoma of tongue", "Hamartomatous polyposis", "Hammertoe", "Hamstring contractures", "Hand apraxia", "Hand clenching", "Hand muscle weakness", "Hand oligodactyly", "Hand polydactyly", "Hand tremor", "Handgrip myotonia", "Happy demeanor", "Hashimoto thyroiditis", "Head banging", "Head titubation", "Head tremor", "Headache", "Heart block", "Heat intolerance", "Heinz bodies", "Hemangioblastoma", "Hemangiomatosis", "Hematochezia", "Hematological neoplasm", "Hemianopia", "Hemiatrophy", "Hemifacial spasm", "Hemihypertrophy", "Hemimegalencephaly", "Hemiparesis", "Hemiplegia hemiparesis", "Hemivertebrae", "Hemoglobinuria", "Hemolytic anemia", "Hemoptysis", "Hemorrhage of the eye", "Heparan sulfate excretion in urine", "Hepatic cysts", "Hepatic encephalopathy", "Hepatic failure", "Hepatic fibrosis", "Hepatic necrosis", "Hepatitis", "Hepatoblastoma", "Hepatocellular adenoma", "Hepatocellular carcinoma", "Hepatomegaly", "Hepatosplenomegaly", "Hereditary nonpolyposis colorectal carcinoma", "Hernia", "Herpes simplex encephalitis", "Heterochromia iridis", "Heterogeneous", "Heteronymous hemianopia", "Heterotaxy", "Heterotropia", "Hiatus hernia", "High anterior hairline", "High forehead", "High frequency hearing impairment", "High frequency sensorineural hearing impairment", "High hypermetropia", "High myopia", "High narrow palate", "High output congestive heart failure", "High palate", "High pitched voice", "Highly arched eyebrow", "Hip contracture", "Hip dislocation", "Hip dysplasia", "Hip flexor weakness", "Hip osteoarthritis", "Hip pain", "Hip subluxation", "Hirsutism", "Hoarse cry", "Hoarse voice", "Hodgkin lymphoma", "Holoprosencephaly", "Homocystinuria", "Honeycomb lung", "Horizontal eyebrow", "Horizontal nystagmus", "Horizontal pendular nystagmus", "Horizontal ribs", "Horseshoe kidney", "Humeroradial synostosis", "Hydranencephaly", "Hydrocele testis", "Hydrocephalus", "Hydrops fetalis", "Hydroureter", "Hydroxyprolinuria", "Hyperactive deep tendon reflexes", "Hyperactive patellar reflex", "Hyperactivity", "Hyperacusis", "Hyperaldosteronism", "Hyperammonemia", "Hyperautofluorescent macular lesion", "Hyperautofluorescent retinal lesion", "Hypercalcemia", "Hyperchloremic acidosis", "Hypercholesterolemia", "Hypercoagulability", "Hyperconvex fingernails", "Hyperconvex nail", "Hyperesthesia", "Hyperextensibility at wrists", "Hyperextensibility of the finger joints", "Hyperextensible skin", "Hypergalactosemia", "Hyperglycemia", "Hypergonadotropic hypogonadism", "Hypergranulosis", "Hyperhidrosis", "Hyperhomocystinemia", "Hyperinsulinemic hypoglycemia", "Hyperintensity of cerebral white matter on mri", "Hyperkalemia", "Hyperkeratosis", "Hyperkeratotic papule", "Hyperketonemia", "Hyperkinetic movements", "Hyperlipidemia", "Hyperlipoproteinemia", "Hyperlordosis", "Hypermagnesemia", "Hypermethioninemia", "Hypermetric saccades", "Hypermetropia", "Hypernatriuria", "Hyperorality", "Hyperostosis", "Hyperoxaluria", "Hyperparathyroidism", "Hyperphenylalaninemia", "Hyperphosphatemia", "Hyperphosphaturia", "Hyperpigmentation in sun exposed areas", "Hyperpigmentation of the fundus", "Hyperpigmentation of the skin", "Hyperpituitarism", "Hyperplasia of the maxilla", "Hyperreflexia", "Hyperreflexia in upper limbs", "Hypersomnia", "Hypersplenism", "Hypertelorism", "Hypertension associated with pheochromocytoma", "Hypertensive crisis", "Hyperthyroidism", "Hypertonia", "Hypertrichosis", "Hypertriglyceridemia", "Hypertrophic cardiomyopathy", "Hypertrophic nerve changes", "Hyperuricemia", "Hyperuricosuria", "Hyperventilation", "Hypoamylasemia", "Hypocalcemia", "Hypocalcemic seizures", "Hypocalcemic tetany", "Hypocalciuria", "Hypochloremia", "Hypocholesterolemia", "Hypochromia", "Hypochromic anemia", "Hypochromic microcytic anemia", "Hypodontia", "Hypoglycemic coma", "Hypoglycemic seizures", "Hypoglycorrhachia", "Hypogonadism", "Hypogonadotropic hypogonadism", "Hypohidrosis", "Hypoinsulinemia", "Hypointensity of cerebral white matter on mri", "Hypokalemia", "Hypokalemic alkalosis", "Hypokalemic metabolic alkalosis", "Hypoketotic hypoglycemia", "Hypokinesia", "Hypolipidemia", "Hypolipoproteinemia", "Hypomelanotic macule", "Hypomethioninemia", "Hypometric saccades", "Hypomimic face", "Hypoparathyroidism", "Hypophosphatemia", "Hypophosphatemic rickets", "Hypopigmentation of the fundus", "Hypopigmentation of the skin", "Hypopigmented macule", "Hypopigmented skin patches", "Hypopituitarism", "Hypoplasia of olfactory tract", "Hypoplasia of penis", "Hypoplasia of teeth", "Hypoplasia of the bladder", "Hypoplasia of the brainstem", "Hypoplasia of the corpus callosum", "Hypoplasia of the ear cartilage", "Hypoplasia of the epiglottis", "Hypoplasia of the femoral head", "Hypoplasia of the fovea", "Hypoplasia of the frontal lobes", "Hypoplasia of the iris", "Hypoplasia of the musculature", "Hypoplasia of the odontoid process", "Hypoplasia of the olfactory bulb", "Hypoplasia of the pons", "Hypoplasia of the radius", "Hypoplasia of the uterus", "Hypoplasia of the vagina", "Hypoplasia of the ventral pons", "Hypoplastic anemia", "Hypoplastic aortic arch", "Hypoplastic cervical vertebrae", "Hypoplastic dermoepidermal hemidesmosomes", "Hypoplastic facial bones", "Hypoplastic female external genitalia", "Hypoplastic fifth fingernail", "Hypoplastic fifth toenail", "Hypoplastic fingernail", "Hypoplastic frontal sinuses", "Hypoplastic heart", "Hypoplastic helices", "Hypoplastic hippocampus", "Hypoplastic ilia", "Hypoplastic iliac wing", "Hypoplastic ischia", "Hypoplastic labia majora", "Hypoplastic labia minora", "Hypoplastic nipples", "Hypoplastic pelvis", "Hypoplastic pubic rami", "Hypoplastic spleen", "Hypoplastic toenails", "Hypoplastic vertebral bodies", "Hypoproteinemia", "Hyporeflexia", "Hyporeflexia of lower limbs", "Hyporeflexia of upper limbs", "Hyposmia", "Hypotelorism", "Hypotension", "Hypothalamic gonadotropin releasing hormone deficiency", "Hypothalamic hamartoma", "Hypothalamic hypothyroidism", "Hypothermia", "Hypotriglyceridemia", "Hypouricemia", "Hypoventilation", "Hypovolemic shock", "Hypsarrhythmia", "Ichthyosis", "Ileus", "Immotile sperm", "Immune dysregulation", "Immunodeficiency", "Immunologic hypersensitivity", "Impacted tooth", "Impaired adp induced platelet aggregation", "Impaired antigen specific response", "Impaired collagen induced platelet aggregation", "Impaired distal proprioception", "Impaired distal tactile sensation", "Impaired distal vibration sensation", "Impaired epinephrine induced platelet aggregation", "Impaired glucose tolerance", "Impaired horizontal smooth pursuit", "Impaired lymphocyte transformation with phytohemagglutinin", "Impaired mastication", "Impaired neutrophil bactericidal activity", "Impaired oropharyngeal swallow response", "Impaired pain sensation", "Impaired proprioception", "Impaired renal concentrating ability", "Impaired smooth pursuit", "Impaired social interactions", "Impaired t cell function", "Impaired tactile sensation", "Impaired tandem gait", "Impaired temperature sensation", "Impaired use of nonverbal behaviors", "Impaired vibration sensation at ankles", "Impaired vibration sensation in the lower limbs", "Impaired vibratory sensation", "Impaired visuospatial constructive cognition", "Impairment in personality functioning", "Impairment of activities of daily living", "Impotence", "Inability to walk", "Inappropriate antidiuretic hormone secretion", "Inappropriate behavior", "Inappropriate crying", "Inappropriate laughter", "Inappropriate sexual behavior", "Incisor macrodontia", "Incomitant strabismus", "Incomplete penetrance", "Incomprehensible speech", "Incoordination", "Increased adipose tissue", "Increased arm span", "Increased aspartate family amino acid level in urine", "Increased b cell count", "Increased blood pressure", "Increased blood urea nitrogen", "Increased body mass index", "Increased body weight", "Increased bone mineral density", "Increased c peptide level", "Increased cerebral lipofuscin", "Increased circulating acth level", "Increased circulating androgen concentration", "Increased circulating antibody level", "Increased circulating cortisol level", "Increased circulating gonadotropin level", "Increased circulating iga level", "Increased circulating igg level", "Increased circulating igm level", "Increased circulating lactate dehydrogenase concentration", "Increased circulating prolactin concentration", "Increased circulating renin level", "Increased connective tissue", "Increased csf lactate", "Increased density of long bones", "Increased endomysial connective tissue", "Increased fecal porphyrin", "Increased female libido", "Increased head circumference", "Increased hepatic glycogen content", "Increased hepatocellular lipid droplets", "Increased intracranial pressure", "Increased intramyocellular lipid droplets", "Increased laxity of ankles", "Increased ldl cholesterol concentration", "Increased level of hippuric acid in urine", "Increased level of l fucose in urine", "Increased mean corpuscular hemoglobin concentration", "Increased mean corpuscular volume", "Increased megakaryocyte count", "Increased muscle fatiguability", "Increased muscle glycogen content", "Increased muscle lipid content", "Increased nuchal translucency", "Increased overbite", "Increased proteinogenic amino acid level in urine", "Increased sensitivity to ionizing radiation", "Increased serine family amino acid in urine", "Increased serum iron", "Increased serum lactate", "Increased serum pyruvate", "Increased serum serotonin", "Increased serum testosterone level", "Increased skull ossification", "Increased sulfur amino acid level in urine", "Increased susceptibility to fractures", "Increased theta frequency activity in eeg", "Increased total bilirubin", "Increased urinary cortisol level", "Increased urinary non proteinogenic amino acid level", "Increased urinary potassium", "Increased urine alpha ketoglutarate concentration", "Increased urine proteinogenic amino acid derivative level", "Increased vertebral height", "Ineffective esophageal peristalsis", "Infantile axial hypotonia", "Infantile encephalopathy", "Infantile muscular hypotonia", "Infantile onset", "Infantile spasms", "Infection related seizure", "Infectious encephalitis", "Inferior lens subluxation", "Inferior vermis hypoplasia", "Infertility", "Inflammation of the large intestine", "Inflammatory abnormality of the eye", "Inflexible adherence to routines or rituals", "Inguinal freckling", "Inguinal hernia", "Insidious onset", "Insomnia", "Inspiratory stridor", "Insulin resistance", "Insulin resistant diabetes mellitus", "Intellectual disability borderline", "Intellectual disability mild", "Intellectual disability moderate", "Intellectual disability profound", "Intellectual disability progressive", "Intellectual disability severe", "Intercostal muscle weakness", "Interictal eeg abnormality", "Intermittent diarrhea", "Intermittent episodes of respiratory insufficiency due to muscle weakness", "Internally nucleated skeletal muscle fibers", "Interrupted aortic arch", "Interstitial cardiac fibrosis", "Interstitial pneumonitis", "Intestinal atresia", "Intestinal bleeding", "Intestinal fistula", "Intestinal hypoplasia", "Intestinal malrotation", "Intestinal perforation", "Intestinal polyp", "Intestinal pseudo obstruction", "Intraalveolar phospholipid accumulation", "Intracellular accumulation of autofluorescent lipopigment storage material", "Intracranial hemorrhage", "Intracranial meningioma", "Intractable diarrhea", "Intrauterine growth retardation", "Intrinsic hand muscle atrophy", "Intussusception", "Inverted nipples", "Involuntary movements", "Iridocyclitis", "Iris atrophy", "Iris coloboma", "Iris hypopigmentation", "Iron accumulation in brain", "Iron accumulation in globus pallidus", "Iron deficiency anemia", "Irregular acetabular roof", "Irregular capital femoral epiphysis", "Irregular epiphyses", "Irregular femoral epiphysis", "Irregular hyperpigmentation", "Irregular iliac crest", "Irregular menstruation", "Irregular vertebral endplates", "Irritability", "Ischemic stroke", "J shaped sella turcica", "Jaundice", "Jerky head movements", "Jerky ocular pursuit movements", "Joint contracture of the 5th finger", "Joint contracture of the hand", "Joint contractures involving the joints of the feet", "Joint dislocation", "Joint hemorrhage", "Joint hyperflexibility", "Joint hypermobility", "Joint laxity", "Joint stiffness", "Joint subluxation", "Joint swelling", "Juvenile aseptic necrosis", "Juvenile cataract", "Juvenile myelomonocytic leukemia", "Juvenile onset", "Juvenile rheumatoid arthritis", "Keloids", "Keratitis", "Keratoconjunctivitis", "Keratosis pilaris", "Ketoacidosis", "Ketonuria", "Ketosis", "Ketotic hypoglycemia", "Kinetic tremor", "Kinked brainstem", "Knee clonus", "Knee dislocation", "Knee flexion contracture", "Kyphoscoliosis", "Kyphosis", "Labial hypertrophy", "Lack of insight", "Lack of peer relationships", "Lack of skin elasticity", "Lack of t cell function", "Lacrimal duct atresia", "Lacrimal duct stenosis", "Lacrimation abnormality", "Lactic acidosis", "Lacticaciduria", "Lactose intolerance", "Lagopthalmos", "Lambdoidal craniosynostosis", "Language impairment", "Large basal ganglia", "Large beaked nose", "Large earlobe", "Large face", "Large fleshy ears", "Large for gestational age", "Large foramen magnum", "Large forehead", "Large hands", "Large iliac wing", "Large intestinal polyposis", "Large placenta", "Large sella turcica", "Laryngeal cleft", "Laryngeal dystonia", "Laryngeal hypoplasia", "Laryngeal stenosis", "Laryngeal stridor", "Laryngomalacia", "Laryngotracheomalacia", "Late onset", "Lateral clavicle hook", "Leber optic atrophy", "Left atrial enlargement", "Left bundle branch block", "Left to right shunt", "Left ventricular hypertrophy", "Left ventricular noncompaction cardiomyopathy", "Left ventricular outflow tract obstruction", "Left ventricular systolic dysfunction", "Leg muscle stiffness", "Leiomyosarcoma", "Lens subluxation", "Lethal skeletal dysplasia", "Lethargy", "Leukemia", "Leukocytosis", "Leukodystrophy", "Leukoencephalopathy", "Leukonychia", "Leukopenia", "Lewy bodies", "Leydig cell neoplasia", "Lichenification", "Limb ataxia", "Limb dysmetria", "Limb dystonia", "Limb fasciculations", "Limb girdle muscle atrophy", "Limb girdle muscle weakness", "Limb girdle muscular dystrophy", "Limb hypertonia", "Limb joint contracture", "Limb muscle weakness", "Limb myoclonus", "Limb pain", "Limb tremor", "Limb undergrowth", "Limitation of joint mobility", "Limitation of knee mobility", "Limitation of movement at ankles", "Limitation of neck motion", "Limited elbow extension", "Limited elbow movement", "Limited extraocular movements", "Limited hip extension", "Limited hip movement", "Limited knee extension", "Limited wrist movement", "Lingual dystonia", "Lipid accumulation in hepatocytes", "Lipoatrophy", "Lipodystrophy", "Lipoma", "Lissencephaly", "Liver abscess", "Lobar holoprosencephaly", "Lobulated tongue", "Localized hirsutism", "Localized osteoporosis", "Localized skin lesion", "Long clavicles", "Long ear", "Long eyelashes", "Long fingers", "Long foot", "Long hallux", "Long neck", "Long nose", "Long palm", "Long palpebral fissure", "Long penis", "Long philtrum", "Long thorax", "Long toe", "Long upper lip", "Loss of ability to walk", "Loss of consciousness", "Loss of eyelashes", "Loss of purkinje cells in the cerebellar vermis", "Loss of speech", "Loss of subcutaneous adipose tissue in limbs", "Loss of voice", "Low alkaline phosphatase", "Low anterior hairline", "Low apgar score", "Low back pain", "Low frustration tolerance", "Low grade fever", "Low hanging columella", "Low levels of vitamin d", "Low molecular weight proteinuria", "Low plasma citrulline", "Low posterior hairline", "Low self esteem", "Low set nipples", "Low set posteriorly rotated ears", "Lower extremity joint dislocation", "Lower eyelid coloboma", "Lower limb amyotrophy", "Lower limb asymmetry", "Lower limb hyperreflexia", "Lower limb hypertonia", "Lower limb metaphyseal irregularity", "Lower limb muscle weakness", "Lower limb pain", "Lower limb spasticity", "Lower limb undergrowth", "Lumbar hyperlordosis", "Lumbar kyphosis", "Lumbar scoliosis", "Lung adenocarcinoma", "Lymphangiectasis", "Lymphangioma", "Lymphedema", "Lymphocytosis", "Lymphoma", "Lymphopenia", "Lymphoproliferative disorder", "Macrocephaly at birth", "Macrocytic anemia", "Macrodactyly", "Macrodontia", "Macrodontia of permanent maxillary central incisor", "Macroglossia", "Macrogyria", "Macroorchidism", "Macroscopic hematuria", "Macrotia", "Macrovesicular hepatic steatosis", "Macular atrophy", "Macular coloboma", "Macular degeneration", "Macular dystrophy", "Macular hyperpigmentation", "Macular hypoplasia", "Macular purpura", "Macular thickening", "Macule", "Malabsorption", "Malar prominence", "Male hypogonadism", "Male infertility", "Male pseudohermaphroditism", "Male reproductive system neoplasm", "Male sexual dysfunction", "Malignant genitourinary tract tumor", "Malignant hyperthermia", "Malignant neoplasm of the central nervous system", "Malnutrition", "Malrotation of small bowel", "Mandibular aplasia", "Mandibular prognathia", "Mania", "Mask like facies", "Mastoiditis", "Maternal diabetes", "Maternal hypertension", "Maturity onset diabetes of the young", "Meconium stained amniotic fluid", "Medial flaring of the eyebrow", "Median cleft lip", "Median cleft palate", "Mediastinal lymphadenopathy", "Medullary nephrocalcinosis", "Medulloblastoma", "Megalencephaly", "Megaloblastic anemia", "Megalocornea", "Melanocytic nevus", "Melanoma", "Melena", "Membranoproliferative glomerulonephritis", "Memory impairment", "Meningioma", "Meningitis", "Meningocele", "Meningoencephalocele", "Menorrhagia", "Mental deterioration", "Mesoaxial hand polydactyly", "Mesoaxial polydactyly", "Mesomelia", "Metabolic acidosis", "Metabolic alkalosis", "Metacarpophalangeal joint contracture", "Metamorphopsia", "Metaphyseal chondrodysplasia", "Metaphyseal cupping", "Metaphyseal dysplasia", "Metaphyseal irregularity", "Metaphyseal sclerosis", "Metaphyseal spurs", "Metaphyseal striations", "Metaphyseal widening", "Metatarsal synostosis", "Metatarsus adductus", "Metatarsus valgus", "Methemoglobinemia", "Methylmalonic acidemia", "Methylmalonic aciduria", "Metopic synostosis", "Metrorrhagia", "Microcornea", "Microcytic anemia", "Microdontia", "Microglossia", "Micrographia", "Micromelia", "Micronodular cirrhosis", "Micropenis", "Microphallus", "Microretrognathia", "Microscopic hematuria", "Microvesicular hepatic steatosis", "Middle age onset", "Midface retrusion", "Midline defect of the nose", "Migraine", "Mild global developmental delay", "Mild hearing impairment", "Mild microcephaly", "Mild postnatal growth retardation", "Mild short stature", "Mildly elevated creatine kinase", "Milia", "Minicore myopathy", "Minimal change glomerulonephritis", "Misalignment of incisors", "Missing ribs", "Mitochondrial inheritance", "Mitochondrial myopathy", "Mitochondrial respiratory chain defects", "Mitral stenosis", "Mitral valve calcification", "Mitral valve prolapse", "Mitten deformity", "Mixed demyelinating and axonal polyneuropathy", "Mixed hearing impairment", "Mixed hypo and hyperpigmentation of the skin", "Moderate albuminuria", "Moderate global developmental delay", "Moderate sensorineural hearing impairment", "Moderately reduced visual acuity", "Molar tooth sign on mri", "Molluscoid pseudotumors", "Molluscum contagiosum", "Monochromacy", "Monocytosis", "Monotonic speech", "Mood swings", "Morning glory anomaly", "Morning myoclonic jerks", "Morphological abnormality of the corticospinal tract", "Morphological abnormality of the middle ear", "Morphological abnormality of the pyramidal tract", "Morphological abnormality of the vestibule of the inner ear", "Mortality aging", "Motor axonal neuropathy", "Motor delay", "Motor deterioration", "Motor neuron atrophy", "Motor polyneuropathy", "Motor regression", "Motor seizure", "Motor tics", "Mottled pigmentation", "Movement abnormality of the tongue", "Moyamoya phenomenon", "Mucosal telangiectasiae", "Multicystic kidney dysplasia", "Multifactorial inheritance", "Multifocal cerebral white matter abnormalities", "Multifocal epileptiform discharges", "Multifocal seizures", "Multiple cafe au lait spots", "Multiple enchondromatosis", "Multiple exostoses", "Multiple gastric polyps", "Multiple glomerular cysts", "Multiple impacted teeth", "Multiple joint contractures", "Multiple joint dislocation", "Multiple lentigines", "Multiple lipomas", "Multiple mitochondrial dna deletions", "Multiple myeloma", "Multiple prenatal fractures", "Multiple renal cysts", "Multiple rib fractures", "Multiple rows of eyelashes", "Multiple suture craniosynostosis", "Muscle abnormality related to mitochondrial dysfunction", "Muscle fiber atrophy", "Muscle fiber inclusion bodies", "Muscle fiber necrosis", "Muscle fiber splitting", "Muscle fiber tubular inclusions", "Muscle fibrillation", "Muscle flaccidity", "Muscle hypertrophy of the lower extremities", "Muscle spasm", "Muscle stiffness", "Muscle weakness", "Muscular dystrophy", "Muscular hypotonia of the trunk", "Muscular ventricular septal defect", "Mutism", "Myalgia", "Mydriasis", "Myelodysplasia", "Myelofibrosis", "Myeloid leukemia", "Myelomeningocele", "Myelopathy", "Myeloproliferative disorder", "Myocardial fibrosis", "Myoclonic absence seizure", "Myoclonic seizure", "Myoclonic spasms", "Myoclonus", "Myofibrillar myopathy", "Myoglobinuria", "Myokymia", "Myopathic facies", "Myopathy", "Myopia", "Myositis", "Myotonia", "Naevus flammeus of the eyelid", "Nail dysplasia", "Nail dystrophy", "Nail pits", "Narrow face", "Narrow foot", "Narrow foramen obturatorium", "Narrow forehead", "Narrow iliac wing", "Narrow internal auditory canal", "Narrow jaw", "Narrow mouth", "Narrow nasal bridge", "Narrow nasal ridge", "Narrow nose", "Narrow palate", "Narrow palm", "Narrow palpebral fissure", "Narrow pelvis bone", "Narrow vertebral interpedicular distance", "Nasal congestion", "Nasal regurgitation", "Nasal speech", "Nasogastric tube feeding", "Nasogastric tube feeding in infancy", "Nasolacrimal duct obstruction", "Natal tooth", "Nausea", "Nausea and vomiting", "Neck flexor weakness", "Neck muscle weakness", "Negativism", "Nemaline bodies", "Neonatal alloimmune thrombocytopenia", "Neonatal asphyxia", "Neonatal breathing dysregulation", "Neonatal death", "Neonatal hyperbilirubinemia", "Neonatal hypoglycemia", "Neonatal hypotonia", "Neonatal insulin dependent diabetes mellitus", "Neonatal onset", "Neonatal respiratory distress", "Neoplasm", "Neoplasm by histology", "Neoplasm of fatty tissue", "Neoplasm of head and neck", "Neoplasm of striated muscle", "Neoplasm of the adrenal cortex", "Neoplasm of the adrenal gland", "Neoplasm of the breast", "Neoplasm of the colon", "Neoplasm of the ear", "Neoplasm of the endocrine system", "Neoplasm of the eye", "Neoplasm of the gallbladder", "Neoplasm of the gastrointestinal tract", "Neoplasm of the genitourinary tract", "Neoplasm of the heart", "Neoplasm of the inner ear", "Neoplasm of the large intestine", "Neoplasm of the larynx", "Neoplasm of the liver", "Neoplasm of the male external genitalia", "Neoplasm of the middle ear", "Neoplasm of the nervous system", "Neoplasm of the oral cavity", "Neoplasm of the pancreas", "Neoplasm of the parathyroid gland", "Neoplasm of the peripheral nervous system", "Neoplasm of the pituitary gland", "Neoplasm of the rectum", "Neoplasm of the respiratory system", "Neoplasm of the skeletal system", "Neoplasm of the skin", "Neoplasm of the small intestine", "Neoplasm of the stomach", "Neoplasm of the thyroid gland", "Neoplasm of the tongue", "Neoplasm of the tracheobronchial system", "Nephritis", "Nephrocalcinosis", "Nephrogenic diabetes insipidus", "Nephrolithiasis", "Nephronophthisis", "Nephropathy", "Nephrotic syndrome", "Neuralgia", "Neurodegeneration", "Neuroendocrine neoplasm", "Neurofibrillary tangles", "Neurofibromas", "Neurogenic bladder", "Neuroinflammation", "Neuroma", "Neuromuscular dysphagia", "Neuronal loss in basal ganglia", "Neuronal loss in central nervous system", "Neuronal loss in the cerebral cortex", "Neuropathic arthropathy", "Neutropenia in presence of anti neutropil antibodies", "Neutrophilia", "Nevus", "Night sweats", "No social interaction", "Nocturia", "Nocturnal hypoventilation", "Nocturnal seizures", "Nodular goiter", "Non hodgkin lymphoma", "Non medullary thyroid carcinoma", "Non midline cleft lip", "Non midline cleft palate", "Non motor seizure", "Non obstructive azoospermia", "Noncommunicating hydrocephalus", "Noncompaction cardiomyopathy", "Nonimmune hydrops fetalis", "Nonketotic hypoglycemia", "Nonprogressive", "Nonprogressive cerebellar ataxia", "Nonprogressive encephalopathy", "Nonspherocytic hemolytic anemia", "Normochromic anemia", "Normocytic anemia", "Nuclear cataract", "Numerous nevi", "Numerous pigmented freckles", "Nyctalopia", "Nystagmus induced head nodding", "Obsessive compulsive behavior", "Obsessive compulsive trait", "Obstructive sleep apnea", "Occipital cortical atrophy", "Occipital encephalocele", "Occipital meningocele", "Ocular albinism", "Ocular anterior segment dysgenesis", "Ocular pain", "Oculogyric crisis", "Oculomotor apraxia", "Oculomotor nerve palsy", "Odontogenic neoplasm", "Oligoarthritis", "Oligodactyly", "Oligodontia", "Oligohydramnios", "Oligomenorrhea", "Oligosacchariduria", "Oligospermia", "Oliguria", "Olivopontocerebellar atrophy", "Olivopontocerebellar hypoplasia", "Omphalocele", "Onion bulb formation", "Onset", "Onychogryposis", "Onychogryposis of toenails", "Onycholysis", "Onychomycosis", "Open angle glaucoma", "Open bite", "Open mouth", "Open operculum", "Ophthalmoparesis", "Opisthotonus", "Opportunistic infection", "Opsoclonus", "Optic atrophy", "Optic disc coloboma", "Optic disc hypoplasia", "Optic disc pallor", "Optic nerve dysplasia", "Optic nerve hypoplasia", "Optic neuropathy", "Oral aversion", "Oral cavity bleeding", "Oral cleft", "Oral leukoplakia", "Oral mucosal blisters", "Oral pharyngeal dysphagia", "Oral ulcer", "Orchitis", "Organic aciduria", "Orofacial dyskinesia", "Oromandibular dystonia", "Oromotor apraxia", "Oroticaciduria", "Orthopnea", "Orthostatic hypotension", "Orthostatic hypotension due to autonomic dysfunction", "Osteoarthritis", "Osteochondroma", "Osteolysis", "Osteolysis involving bones of the feet", "Osteolysis involving bones of the upper limbs", "Osteolytic defects of the distal phalanges of the hand", "Osteomalacia", "Osteomyelitis", "Osteopenia", "Osteopetrosis", "Osteoporosis", "Osteosarcoma", "Otitis media", "Otosclerosis", "Oval face", "Ovarian carcinoma", "Ovarian cyst", "Ovarian gonadoblastoma", "Ovarian neoplasm", "Ovarian papillary adenocarcinoma", "Overfolding of the superior helices", "Overfriendliness", "Overgrowth", "Overhanging nasal tip", "Overlapping fingers", "Overlapping toe", "Overriding aorta", "Overtubulated long bones", "Overweight", "Ovoid vertebral bodies", "Ovotestis", "Oxycephaly", "Pace of progression", "Pain", "Pain in head and neck region", "Pain insensitivity", "Painless fractures due to injury", "Palate fistula", "Pallor", "Palmar hyperhidrosis", "Palmar pits", "Palmar telangiectasia", "Palmoplantar blistering", "Palmoplantar cutis laxa", "Palmoplantar hyperhidrosis", "Palpebral edema", "Palpitations", "Pancreatic adenocarcinoma", "Pancreatic cysts", "Pancreatic endocrine tumor", "Pancreatic fibrosis", "Pancreatic hypoplasia", "Pancreatic islet cell hyperplasia", "Pancreatitis", "Pancytopenia", "Panhypogammaglobulinemia", "Panhypopituitarism", "Panniculitis", "Papillary renal cell carcinoma", "Papillary thyroid carcinoma", "Papilledema", "Papilloma", "Papule", "Paracentral scotoma", "Paraganglioma", "Parakeratosis", "Paralysis", "Paranoia", "Paraparesis", "Paraplegia", "Paraplegia paraparesis", "Parasomnia", "Parathyroid adenoma", "Parathyroid carcinoma", "Parathyroid hyperplasia", "Paresthesia", "Parietal bossing", "Parietal cortical atrophy", "Parietal foramina", "Parkinsonism", "Parkinsonism with favorable response to dopaminergic medication", "Paronychia", "Paroxysmal bursts of laughter", "Paroxysmal dyskinesia", "Paroxysmal dystonia", "Paroxysmal involuntary eye movements", "Paroxysmal ventricular tachycardia", "Partial absence of thumb", "Partial agenesis of the corpus callosum", "Partial albinism", "Partial anomalous pulmonary venous return", "Partial duplication of the phalanx of hand", "Patchy alopecia", "Patchy changes of bone mineral density", "Patchy hypopigmentation of hair", "Patchy palmoplantar hyperkeratosis", "Patellar aplasia", "Patellar dislocation", "Patellar hypoplasia", "Patellar subluxation", "Patent ductus arteriosus", "Patent foramen ovale", "Pathologic fracture", "Pectus carinatum", "Pectus excavatum", "Pectus excavatum of inferior sternum", "Pedal edema", "Pediatric onset", "Peg shaped maxillary lateral incisors", "Pelvic girdle muscle weakness", "Pelvic kidney", "Pendular nystagmus", "Penetrating foot ulcers", "Peptic ulcer", "Perianal abscess", "Periauricular skin pits", "Pericardial effusion", "Pericarditis", "Perifoveal ring of hyperautofluorescence", "Perimembranous ventricular septal defect", "Periodic paralysis", "Periodontitis", "Periorbital edema", "Periorbital fullness", "Peripheral arterial stenosis", "Peripheral arteriovenous fistula", "Peripheral axonal degeneration", "Peripheral axonal neuropathy", "Peripheral cyanosis", "Peripheral demyelination", "Peripheral edema", "Peripheral hypermyelination", "Peripheral hypomyelination", "Peripheral neuropathy", "Peripheral opacification of the cornea", "Peripheral pulmonary artery stenosis", "Peripheral retinal avascularization", "Peripheral visual field loss", "Periportal fibrosis", "Perisylvian polymicrogyria", "Peritoneal abscess", "Peritonitis", "Periventricular cysts", "Periventricular heterotopia", "Periventricular leukomalacia", "Periventricular nodular heterotopia", "Periventricular white matter hyperintensities", "Peroneal muscle atrophy", "Perseveration", "Persistence of hemoglobin f", "Persistence of primary teeth", "Persistent ebv viremia", "Persistent head lag", "Personality changes", "Personality disorder", "Pes cavus", "Pes planus", "Pes valgus", "Petechiae", "Peters anomaly", "Phalangeal dislocation", "Pharyngitis", "Phenotypic variability", "Pheochromocytoma", "Phimosis", "Phocomelia", "Phonophobia", "Photophobia", "Photopsia", "Photoreceptor layer loss on macular oct", "Phthisis bulbi", "Physical urticaria", "Pierre robin sequence", "Pigmentary retinopathy", "Pili canaliculi", "Pili torti", "Pilomatrixoma", "Pineal cyst", "Pituitary adenoma", "Pituitary growth hormone cell adenoma", "Pituitary hypothyroidism", "Pituitary prolactin cell adenoma", "Plagiocephaly", "Plantar hyperkeratosis", "Platybasia", "Platyspondyly", "Pleural effusion", "Pleuritis", "Pneumonia", "Pneumothorax", "Poikilocytosis", "Poikiloderma", "Pointed chin", "Polar cataract", "Pollakisuria", "Polyarticular arthropathy", "Polyclonal elevation of igm", "Polycystic kidney dysplasia", "Polycystic liver disease", "Polycythemia", "Polydactyly", "Polygenic inheritance", "Polyhydramnios", "Polymicrogyria", "Polyneuropathy", "Polyphagia", "Polysplenia", "Polyuria", "Pontocerebellar atrophy", "Poor appetite", "Poor coordination", "Poor eye contact", "Poor fine motor coordination", "Poor gross motor coordination", "Poor head control", "Poor motor coordination", "Poor speech", "Poor suck", "Poor wound healing", "Porencephalic cyst", "Porokeratosis", "Porphyrinuria", "Portal fibrosis", "Portal vein thrombosis", "Positional foot deformity", "Positive romberg sign", "Post partum hemorrhage", "Postaxial foot polydactyly", "Postaxial hand polydactyly", "Postaxial polydactyly", "Posterior blepharitis", "Posterior embryotoxon", "Posterior fossa cyst", "Posterior pharyngeal cleft", "Posterior pituitary dysgenesis", "Posterior polar cataract", "Posterior subcapsular cataract", "Posterior uveitis", "Posteriorly rotated ears", "Postexertional malaise", "Postnatal growth retardation", "Postural instability", "Postural tremor", "Potter facies", "Preauricular skin tag", "Preaxial foot polydactyly", "Preaxial hand polydactyly", "Preaxial polydactyly", "Precocious atherosclerosis", "Predominantly lower limb lymphedema", "Prelingual sensorineural hearing impairment", "Premature adrenarche", "Premature arteriosclerosis", "Premature birth", "Premature coronary artery atherosclerosis", "Premature graying of hair", "Premature loss of primary teeth", "Premature loss of teeth", "Premature osteoarthritis", "Premature ovarian insufficiency", "Premature pubarche", "Premature rupture of membranes", "Premature skin wrinkling", "Premature thelarche", "Premature ventricular contraction", "Prematurely aged appearance", "Prenatal maternal abnormality", "Prenatal movement abnormality", "Primary adrenal insufficiency", "Primary amenorrhea", "Primary congenital glaucoma", "Primary gonadal insufficiency", "Primary hypercortisolism", "Primary hyperparathyroidism", "Primary microcephaly", "Primary peritoneal carcinoma", "Primitive neuroectodermal tumor", "Primitive reflex", "Productive cough", "Profound global developmental delay", "Profound hearing impairment", "Profound sensorineural hearing impairment", "Progeroid facial appearance", "Progressive", "Progressive cerebellar ataxia", "Progressive distal muscle weakness", "Progressive encephalopathy", "Progressive external ophthalmoplegia", "Progressive extrapyramidal movement disorder", "Progressive flexion contractures", "Progressive gait ataxia", "Progressive hearing impairment", "Progressive inability to walk", "Progressive leukoencephalopathy", "Progressive macrocephaly", "Progressive microcephaly", "Progressive muscle weakness", "Progressive neurologic deterioration", "Progressive night blindness", "Progressive peripheral neuropathy", "Progressive pes cavus", "Progressive proximal muscle weakness", "Progressive psychomotor deterioration", "Progressive pulmonary function impairment", "Progressive sensorineural hearing impairment", "Progressive spastic paraparesis", "Progressive spastic paraplegia", "Progressive spastic quadriplegia", "Progressive spasticity", "Progressive visual field defects", "Progressive visual loss", "Prolinuria", "Prolonged bleeding after dental extraction", "Prolonged bleeding after surgery", "Prolonged bleeding following circumcision", "Prolonged bleeding following procedure", "Prolonged bleeding time", "Prolonged neonatal jaundice", "Prolonged partial thromboplastin time", "Prolonged pr interval", "Prolonged qtc interval", "Prominent antihelix", "Prominent antitragus", "Prominent calcaneus", "Prominent crus of helix", "Prominent digit pad", "Prominent ear helix", "Prominent eyelashes", "Prominent forehead", "Prominent metopic ridge", "Prominent nasal bridge", "Prominent nasal tip", "Prominent nasolabial fold", "Prominent nose", "Prominent occiput", "Prominent sternum", "Prominent superficial blood vessels", "Prominent supraorbital ridges", "Prominent umbilicus", "Prominent veins on trunk", "Proportionate short stature", "Proportionate tall stature", "Proptosis", "Prostate neoplasm", "Protein losing enteropathy", "Protruding ear", "Protruding tongue", "Protrusio acetabuli", "Protuberant abdomen", "Proximal amyotrophy", "Proximal femoral epiphysiolysis", "Proximal femoral metaphyseal abnormality", "Proximal femoral metaphyseal irregularity", "Proximal muscle weakness", "Proximal muscle weakness in lower limbs", "Proximal muscle weakness in upper limbs", "Proximal renal tubular acidosis", "Proximal symphalangism", "Proximal tubulopathy", "Proximal upper limb amyotrophy", "Pruritus", "Pseudoarthrosis", "Pseudobulbar paralysis", "Pseudobulbar signs", "Pseudoepiphyses", "Pseudoepiphyses of hand bones", "Pseudoepiphyses of the metacarpals", "Pseudohypoaldosteronism", "Pseudohypoparathyroidism", "Psoriasiform dermatitis", "Psychogenic non epileptic seizure", "Psychomotor deterioration", "Psychomotor retardation", "Psychosis", "Psychotic episodes", "Psychotic mentation", "Pterygium", "Ptosis", "Puberty and gonadal disorders", "Pulmonary artery atresia", "Pulmonary artery dilatation", "Pulmonary artery hypoplasia", "Pulmonary artery stenosis", "Pulmonary carcinoid tumor", "Pulmonary cyst", "Pulmonary edema", "Pulmonary embolism", "Pulmonary fibrosis", "Pulmonary hemorrhage", "Pulmonary hypoplasia", "Pulmonary infiltrates", "Pulmonary insufficiency", "Pulmonary interstitial high resolution computed tomography abnormality", "Pulmonary venous hypertension", "Pulmonic stenosis", "Pulverulent cataract", "Punctate cataract", "Pure red cell aplasia", "Purpura", "Pustule", "Pyelonephritis", "Pyoderma gangrenosum", "Pyridoxine responsive sideroblastic anemia", "Quadriceps muscle weakness", "Radial bowing", "Radial deviation of the 2nd finger", "Radial deviation of the hand", "Radial deviation of the hand or of fingers of the hand", "Radioulnar dislocation", "Radioulnar synostosis", "Ragged red muscle fibers", "Rapidly progressive", "Raynaud phenomenon", "Reactive hypoglycemia", "Receptive language delay", "Rectal abscess", "Rectal fistula", "Rectal prolapse", "Recurrent", "Recurrent abscess formation", "Recurrent acute respiratory tract infection", "Recurrent aspergillus infections", "Recurrent aspiration pneumonia", "Recurrent bacterial infections", "Recurrent bacterial skin infections", "Recurrent bronchitis", "Recurrent bronchopulmonary infections", "Recurrent corneal erosions", "Recurrent cutaneous abscess formation", "Recurrent ear infections", "Recurrent fever", "Recurrent fractures", "Recurrent gastroenteritis", "Recurrent hand flapping", "Recurrent herpes", "Recurrent hypoglycemia", "Recurrent infection of the gastrointestinal tract", "Recurrent joint dislocation", "Recurrent lower respiratory tract infections", "Recurrent mycobacterial infections", "Recurrent opportunistic infections", "Recurrent otitis media", "Recurrent pancreatitis", "Recurrent paroxysmal headache", "Recurrent pharyngitis", "Recurrent pneumonia", "Recurrent respiratory infections", "Recurrent sinopulmonary infections", "Recurrent sinusitis", "Recurrent skin infections", "Recurrent staphylococcal infections", "Recurrent staphylococcus aureus infections", "Recurrent tonsillitis", "Recurrent upper and lower respiratory tract infections", "Recurrent urinary tract infections", "Recurrent viral infections", "Red eye", "Red green dyschromatopsia", "Red hair", "Reduced antigen specific t cell proliferation", "Reduced antithrombin iii activity", "Reduced brain n acetyl aspartate level by mrs", "Reduced c peptide level", "Reduced circulating prolactin concentration", "Reduced consciousness confusion", "Reduced delayed hypersensitivity", "Reduced factor viii activity", "Reduced factor xi activity", "Reduced factor xii activity", "Reduced factor xiii activity", "Reduced forced expiratory volume in one second", "Reduced forced vital capacity", "Reduced natural killer cell count", "Reduced pancreatic beta cells", "Reduced protein c activity", "Reduced protein s activity", "Reduced renal corticomedullary differentiation", "Reduced sperm motility", "Reduced subcutaneous adipose tissue", "Reduced systolic function", "Reduced tendon reflexes", "Reduced visual acuity", "Reduced vital capacity", "Reduction of neutrophil motility", "Redundant neck skin", "Redundant skin", "Refractory anemia", "Regional abnormality of skin", "Relative macrocephaly", "Renal agenesis", "Renal angiomyolipoma", "Renal cell carcinoma", "Renal cortical cysts", "Renal cortical microcysts", "Renal corticomedullary cysts", "Renal cyst", "Renal duplication", "Renal dysplasia", "Renal fanconi syndrome", "Renal fibrosis", "Renal hamartoma", "Renal hypoplasia", "Renal hypoplasia aplasia", "Renal insufficiency", "Renal magnesium wasting", "Renal malrotation", "Renal phosphate wasting", "Renal potassium wasting", "Renal salt wasting", "Renal sodium wasting", "Renal steatosis", "Renal tubular acidosis", "Renal tubular atrophy", "Renal tubular dysfunction", "Renal tubular epithelial necrosis", "Renovascular hypertension", "Repetitive compulsive behavior", "Respiratory arrest", "Respiratory distress", "Respiratory failure", "Respiratory failure requiring assisted ventilation", "Respiratory insufficiency", "Respiratory insufficiency due to defective ciliary clearance", "Respiratory paralysis", "Respiratory tract infection", "Response to drugs acting on neuromuscular transmission", "Resting tremor", "Restless legs", "Restlessness", "Restrictive behavior", "Restrictive cardiomyopathy", "Restrictive ventilatory defect", "Reticular hyperpigmentation", "Reticulated skin pigmentation", "Reticulocytopenia", "Reticulocytosis", "Retinal arterial tortuosity", "Retinal arteriolar tortuosity", "Retinal atrophy", "Retinal coloboma", "Retinal degeneration", "Retinal detachment", "Retinal dysplasia", "Retinal dystrophy", "Retinal fold", "Retinal hamartoma", "Retinal hemorrhage", "Retinal neovascularization", "Retinal perforation", "Retinal pigment epithelial atrophy", "Retinal pigment epithelial mottling", "Retinal telangiectasia", "Retinal thinning", "Retinal vascular tortuosity", "Retinopathy", "Retrocollis", "Retrognathia", "Rhabdomyolysis", "Rhabdomyosarcoma", "Rhegmatogenous retinal detachment", "Rheumatoid arthritis", "Rheumatoid factor positive", "Rhinitis", "Rhizomelia", "Rhizomelic arm shortening", "Rib fusion", "Rib segmentation abnormalities", "Rickets", "Ridged fingernail", "Ridged nail", "Rieger anomaly", "Right aortic arch with mirror image branching", "Right bundle branch block", "Right ventricular cardiomyopathy", "Right ventricular dilatation", "Right ventricular hypertrophy", "Rigidity", "Rimmed vacuoles", "Rod cone dystrophy", "Rotary nystagmus", "Round ear", "Round face", "Saccadic oscillation", "Saccadic smooth pursuit", "Sacrococcygeal teratoma", "Sagittal craniosynostosis", "Sandal gap", "Sarcoma", "Scaling skin", "Scanning speech", "Scaphocephaly", "Scapular winging", "Scarring", "Scarring alopecia of scalp", "Schistocytosis", "Schizencephaly", "Schizophrenia", "Schwannoma", "Scleral staphyloma", "Sclerocornea", "Scleroderma", "Sclerosis of hand bone", "Sclerosis of skull base", "Scotoma", "Scrotal hypoplasia", "Sea blue histiocytosis", "Seborrheic dermatitis", "Second degree atrioventricular block", "Secondary amenorrhea", "Secondary growth hormone deficiency", "Secondary microcephaly", "Secretory diarrhea", "Secundum atrial septal defect", "Segmental peripheral demyelination remyelination", "Selective tooth agenesis", "Self injurious behavior", "Self mutilation", "Semilobar holoprosencephaly", "Senile plaques", "Sensorimotor neuropathy", "Sensory ataxia", "Sensory axonal neuropathy", "Sensory neuropathy", "Sepsis", "Septate vagina", "Septic arthritis", "Septo optic dysplasia", "Serositis", "Severe b lymphocytopenia", "Severe combined immunodeficiency", "Severe cytomegalovirus infection", "Severe demyelination of the white matter", "Severe expressive language delay", "Severe failure to thrive", "Severe global developmental delay", "Severe hearing impairment", "Severe infection", "Severe intrauterine growth retardation", "Severe lactic acidosis", "Severe muscular hypotonia", "Severe photosensitivity", "Severe postnatal growth retardation", "Severe short limb dwarfism", "Severe short stature", "Severe varicella zoster infection", "Severe viral infection", "Severely reduced visual acuity", "Shagreen patch", "Shallow acetabular fossae", "Shallow anterior chamber", "Shallow orbits", "Shawl scrotum", "Shield chest", "Shock", "Short 1st metacarpal", "Short attention span", "Short chin", "Short clavicles", "Short columella", "Short digit", "Short face", "Short femur", "Short foot", "Short fourth metatarsal", "Short lingual frenulum", "Short long bone", "Short lower limbs", "Short middle phalanx of finger", "Short nail", "Short nose", "Short palm", "Short palpebral fissure", "Short phalanx of the thumb", "Short philtrum", "Short proximal phalanx of finger", "Short ribs", "Short stepped shuffling gait", "Short sternum", "Short thorax", "Short thumb", "Short tibia", "Short umbilical cord", "Short upper lip", "Shortened pr interval", "Shortened qt interval", "Shortening of all distal phalanges of the fingers", "Shortening of all middle phalanges of the fingers", "Shoulder dislocation", "Shoulder girdle muscle atrophy", "Shoulder girdle muscle weakness", "Shoulder pain", "Shuffling gait", "Shyness", "Sick sinus syndrome", "Sideroblastic anemia", "Simple ear", "Simple febrile seizure", "Simplified gyral pattern", "Single fiber emg abnormality", "Single naris", "Single transverse palmar crease", "Single ventricle", "Sinus bradycardia", "Sinus tachycardia", "Sirenomelia", "Skeletal dysplasia", "Skeletal muscle atrophy", "Skeletal muscle hypertrophy", "Skeletal myopathy", "Skin appendage neoplasm", "Skin dimple", "Skin erosion", "Skin nodule", "Skin picking", "Skin pit", "Skin plaque", "Skin rash", "Skin tags", "Skin ulcer", "Skin vesicle", "Skull asymmetry", "Slanting of the palpebral fissure", "Sleep apnea", "Sleep disturbance", "Sleep wake cycle disturbance", "Slender build", "Slender finger", "Slender long bone", "Slender toe", "Sloping forehead", "Slow decrease in visual acuity", "Slow pupillary light response", "Slow saccadic eye movements", "Slowly progressive", "Slurred speech", "Small anterior fontanelle", "Small basal ganglia", "Small cerebral cortex", "Small earlobe", "Small epiphyses", "Small face", "Small for gestational age", "Small hand", "Small intestinal dysmotility", "Small nail", "Small placenta", "Smooth muscle antibody positivity", "Smooth philtrum", "Snoring", "Social and occupational deterioration", "Soft doughy skin", "Soft skin", "Soft tissue neoplasm", "Soft tissue sarcoma", "Solitary median maxillary central incisor", "Somatic mosaicism", "Somatic mutation", "Somatic sensory dysfunction", "Sound sensitivity", "Sparse and thin eyebrow", "Sparse body hair", "Sparse eyebrow", "Sparse eyelashes", "Sparse hair", "Sparse lateral eyebrow", "Sparse or absent eyelashes", "Sparse scalp hair", "Spastic ataxia", "Spastic diplegia", "Spastic dysarthria", "Spastic gait", "Spastic hyperactive bladder", "Spastic paraparesis", "Spastic paraparetic gait", "Spastic paraplegia", "Spastic tetraparesis", "Spastic tetraplegia", "Spasticity", "Specific learning disability", "Speech apraxia", "Speech articulation difficulties", "Spider hemangioma", "Spina bifida", "Spina bifida occulta", "Spinal canal stenosis", "Spinal cord compression", "Spinal cord lesion", "Spinal cord tumor", "Spinal deformities", "Spinal muscular atrophy", "Spinal rigidity", "Spinocerebellar tract degeneration", "Splanchnic vein thrombosis", "Splenomegaly", "Split nail", "Spoken word recognition deficit", "Spondyloepimetaphyseal dysplasia", "Spondyloepiphyseal dysplasia", "Spondylolisthesis", "Spondylolysis", "Spontaneous abortion", "Spontaneous hematomas", "Spontaneous hemolytic crises", "Spontaneous pain sensation", "Spontaneous recurrent epistaxis", "Sporadic", "Spotty hyperpigmentation", "Sprengel anomaly", "Squamous cell carcinoma", "Squamous cell carcinoma of the skin", "Square face", "Squared iliac bones", "St segment elevation", "Stage 5 chronic kidney disease", "Staring gaze", "Status epilepticus", "Status epilepticus with prominent motor symptoms", "Stenosis of the external auditory canal", "Steppage gait", "Stereotypical body rocking", "Stereotypical hand wringing", "Stereotypy", "Steroid resistant nephrotic syndrome", "Stiff skin", "Stillbirth", "Stomach cancer", "Stomatitis", "Stomatocytosis", "Stooped posture", "Streak ovary", "Striae distensae", "Stridor", "Stroke", "Stroke like episode", "Stuttering", "Subacute progressive viral hepatitis", "Subarachnoid hemorrhage", "Subcapsular cataract", "Subcortical band heterotopia", "Subcortical cerebral atrophy", "Subcortical heterotopia", "Subcutaneous hemorrhage", "Subcutaneous nodule", "Subdural hemorrhage", "Subependymal cysts", "Subglottic stenosis", "Submucous cleft of soft and hard palate", "Submucous cleft soft palate", "Subretinal fluid", "Subsarcolemmal accumulations of abnormally shaped mitochondria", "Substantia nigra gliosis", "Subvalvular aortic stenosis", "Sudden death", "Sudden episodic apnea", "Sudden loss of visual acuity", "Suicidal ideation", "Sunken cheeks", "Supernumerary bones of the axial skeleton", "Supernumerary nipple", "Supernumerary spleens", "Supernumerary tooth", "Supernumerary vertebrae", "Supranuclear gaze palsy", "Supranuclear ophthalmoplegia", "Supravalvular aortic stenosis", "Supraventricular arrhythmia", "Supraventricular tachycardia", "Symphalangism affecting the phalanges of the hand", "Symphalangism of middle phalanx of finger", "Symptomatic seizures", "Syncope", "Syndactyly", "Synostosis involving bones of the hand", "Synostosis involving bones of the lower limbs", "Synostosis involving bones of the upper limbs", "Synostosis involving digits", "Synostosis of carpal bones", "Synostosis of carpals tarsals", "Synostosis of joints", "Synostosis of metacarpals metatarsals", "Synovitis", "Syringomyelia", "Systemic lupus erythematosus", "T cell lymphoma", "T lymphocytopenia", "Tachycardia", "Tachypnea", "Talipes calcaneovalgus", "Talipes equinovalgus", "Talipes equinovarus", "Talipes valgus", "Tall chin", "Tall stature", "Tapered distal phalanges of finger", "Tapered finger", "Tarsal synostosis", "Telangiectasia", "Telangiectasia of the skin", "Telecanthus", "Temperature instability", "Temporal cortical atrophy", "Temporal optic disc pallor", "Temporal pattern", "Tented upper lip vermilion", "Teratoma", "Testicular adrenal rest tumor", "Testicular atrophy", "Testicular dysgenesis", "Tetany", "Tetralogy of fallot", "Tetraparesis", "Tetraplegia", "Tetraplegia tetraparesis", "Thenar muscle atrophy", "Thick cerebral cortex", "Thick corpus callosum", "Thick eyebrow", "Thick hair", "Thick lower lip vermilion", "Thick nasal alae", "Thick upper lip vermilion", "Thick vermilion border", "Thickened calvaria", "Thickened cortex of long bones", "Thickened ears", "Thickened helices", "Thickened nuchal skin fold", "Thickened ribs", "Thickened skin", "Thin bony cortex", "Thin clavicles", "Thin eyebrow", "Thin lower lip vermilion", "Thin nail", "Thin ribs", "Thin skin", "Thin upper lip vermilion", "Thin vermilion border", "Third degree atrioventricular block", "Thoracic aortic aneurysm", "Thoracic hypoplasia", "Thoracic kyphoscoliosis", "Thoracic kyphosis", "Thoracic scoliosis", "Thoracolumbar kyphoscoliosis", "Thoracolumbar kyphosis", "Thoracolumbar scoliosis", "Thrombocytosis", "Thromboembolism", "Thyroid adenoma", "Thyroid carcinoma", "Thyroiditis", "Tibial bowing", "Tibial torsion", "Tibialis muscle weakness", "Tics", "Tiger tail banding", "Tinnitus", "Tip toe gait", "Tissue ischemia", "Titubation", "Toe clinodactyly", "Toe syndactyly", "Toe walking", "Toenail dysplasia", "Tongue atrophy", "Tongue fasciculations", "Tongue nodules", "Tongue thrusting", "Tonic seizure", "Tooth malposition", "Torsade de pointes", "Torsion dystonia", "Total anomalous pulmonary venous return", "Toxemia of pregnancy", "Tracheal stenosis", "Tracheobronchomalacia", "Tracheoesophageal fistula", "Tracheomalacia", "Tractional retinal detachment", "Transient global amnesia", "Transient ischemic attack", "Transient neonatal diabetes mellitus", "Transient neutropenia", "Transposition of the great arteries", "Tremor", "Tremor by anatomical site", "Triangular face", "Triangular mouth", "Triangular shaped phalanges of the hand", "Triceps weakness", "Trichorrhexis nodosa", "Tricuspid atresia", "Tricuspid stenosis", "Tricuspid valve prolapse", "Trigonocephaly", "Triphalangeal thumb", "Trismus", "Tritanomaly", "Trophic changes related to pain", "True hermaphroditism", "Truncal ataxia", "Truncal obesity", "Truncal titubation", "Truncus arteriosus", "Tube feeding", "Tubulointerstitial nephritis", "Turricephaly", "Type 1 fibers relatively smaller than type 2 fibers", "Type 1 muscle fiber atrophy", "Type 2 muscle fiber atrophy", "Type 2 muscle fiber predominance", "Type i diabetes mellitus", "Type i transferrin isoform profile", "Type ii diabetes mellitus", "Type ii lissencephaly", "Type ii transferrin isoform profile", "Typical absence seizure", "U shaped upper lip vermilion", "Ulcerative colitis", "Ulnar bowing", "Ulnar claw", "Ulnar deviation of finger", "Ulnar deviation of the 2nd finger", "Ulnar deviation of the hand", "Ulnar deviation of the hand or of fingers of the hand", "Ulnar deviation of the wrist", "Uncombable hair", "Unconjugated hyperbilirubinemia", "Uncontrolled eye movements", "Underdeveloped nasal alae", "Underdeveloped supraorbital ridges", "Underdeveloped tragus", "Undetectable electroretinogram", "Undetectable light and dark adapted electroretinogram", "Undetectable visual evoked potentials", "Unexplained fevers", "Unilateral cleft palate", "Unilateral primary pulmonary dysgenesis", "Unilateral ptosis", "Unilateral renal agenesis", "Unsteady gait", "Unusual fungal infection", "Unusual infection", "Unusual infection by anatomical site", "Unusual skin infection", "Upgaze palsy", "Uplifted earlobe", "Upper airway obstruction", "Upper extremity joint dislocation", "Upper eyelid coloboma", "Upper limb amyotrophy", "Upper limb asymmetry", "Upper limb hypertonia", "Upper limb muscle weakness", "Upper limb pain", "Upper limb postural tremor", "Upper limb spasticity", "Upper limb undergrowth", "Upper motor neuron dysfunction", "Upslanted palpebral fissure", "Ureteral duplication", "Ureteral obstruction", "Ureteral stenosis", "Ureterocele", "Ureteropelvic junction obstruction", "Urethral atresia", "Urethral obstruction", "Urethral stenosis", "Urethral stricture", "Urethral valve", "Urethrovaginal fistula", "Uric acid nephrolithiasis", "Urinary bladder sphincter dysfunction", "Urinary glycosaminoglycan excretion", "Urinary incontinence", "Urinary retention", "Urinary tract neoplasm", "Urinary urgency", "Urogenital fistula", "Urogenital sinus anomaly", "Urticaria", "Uterine prolapse", "Uterus didelphys", "Uveal melanoma", "Uveitis", "Vacuolated lymphocytes", "Vaginal atresia", "Vaginal fistula", "Vaginal neoplasm", "Variable expressivity", "Varicose veins", "Vascular calcification", "Vascular dilatation", "Vascular neoplasm", "Vascular skin abnormality", "Vascular tortuosity", "Vasculitis", "Vegetative state", "Vein of galen aneurysmal malformation", "Velopharyngeal insufficiency", "Venous insufficiency", "Venous malformation", "Venous thrombosis", "Ventilator dependence with inability to wean", "Ventricular arrhythmia", "Ventricular escape rhythm", "Ventricular fibrillation", "Ventricular hypertrophy", "Ventricular preexcitation", "Ventricular septal hypertrophy", "Ventricular tachycardia", "Ventriculomegaly", "Verrucae", "Vertebral arch anomaly", "Vertebral clefting", "Vertebral compression fracture", "Vertebral fusion", "Vertebral hypoplasia", "Vertebral segmentation defect", "Vertebral wedging", "Vertical nystagmus", "Vertical supranuclear gaze palsy", "Vertigo", "Very long chain fatty acid accumulation", "Vestibular dysfunction", "Viral encephalitis", "Viral hepatitis", "Viral infection induced rhabdomyolysis", "Visceral angiomatosis", "Visual acuity test abnormality", "Visual agnosia", "Visual field defect", "Visual fixation instability", "Visual hallucinations", "Visual impairment", "Visual loss", "Vitamin b12 deficiency", "Vitiligo", "Vitreoretinopathy", "Vitreous floaters", "Vitreous hemorrhage", "Vitritis", "Vocal cord paralysis", "Vocal cord paresis", "Volvulus", "Vomiting", "Waddling gait", "Weak cry", "Weak voice", "Weakness due to upper motor neuron dysfunction", "Weakness of facial musculature", "Weakness of long finger extensor muscles", "Weakness of muscles of respiration", "Weakness of the intrinsic hand muscles", "Webbed neck", "Weight loss", "Wheezing", "White forelock", "White hair", "Wide anterior fontanel", "Wide cranial sutures", "Wide intermamillary distance", "Wide mouth", "Wide nasal bridge", "Wide nasal ridge", "Wide nose", "Wide pubic symphysis", "Widely patent fontanelles and sutures", "Widely spaced incisors", "Widely spaced teeth", "Widened cerebral subarachnoid space", "Widened subarachnoid space", "Widow s peak", "Woolly hair", "Wormian bones", "Wrist flexion contracture", "Writer s cramp", "X linked dominant inheritance", "X linked recessive inheritance", "Xanthomatosis", "Xerostomia", "Y shaped metacarpals", "Yellow white lesions of the retina", "Young adult onset", "Zonular cataract"], "available_proteins": ["AAAS", "AARS", "AARS2", "AASS", "ABCB1", "ABCB7", "ABCD3", "ABHD12", "ACACA", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACO2", "ACOX1", "ACP2", "ACSF3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADPRHL2", "ADSL", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP9", "AKT2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALG1", "ALG12", "ALG9", "ANAPC1", "ANAPC2", "ANK3", "ANKFY1", "ANKLE2", "ANLN", "ANO10", "ANO6", "ANXA11", "AP1B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "APC", "APRT", "ARCN1", "ARHGDIA", "ARHGEF2", "ARID1A", "ARL2", "ARL3", "ARL6", "ARL6IP1", "ARPC1B", "ASAH1", "ASCC1", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD3A", "ATIC", "ATP1A1", "ATP2A2", "ATP2B4", "ATP2C1", "ATP5A1", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATP7A", "ATP7B", "ATXN10", "ATXN2", "AURKA", "B3GALT6", "B4GAT1", "BANF1", "BAZ1B", "BCAP31", "BCKDK", "BCL10", "BCS1L", "BICD2", "BLVRA", "BMS1", "BRAT1", "BRCA1", "BRD4", "BUB1B", "BUB3", "BUD23", "C19orf70", "C1QBP", "CAD", "CALD1", "CALR", "CAMK2G", "CAPN1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CC2D1A", "CCDC22", "CCDC47", "CCDC8", "CCNK", "CCT5", "CD2AP", "CD3EAP", "CDC42", "CDC73", "CDH2", "CDK4", "CDK5", "CDK5RAP2", "CELF2", "CEP290", "CFL2", "CHAMP1", "CHD1", "CHD4", "CHD8", "CHEK2", "CHMP1A", "CHMP2B", "CHMP4B", "CHORDC1", "CHP1", "CHST14", "CISD2", "CIZ1", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNNM4", "CNOT1", "CNOT3", "CNP", "COA3", "COA7", "COASY", "COG4", "COG7", "COG8", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COQ8A", "COX14", "COX15", "COX2", "COX4I1", "COX5A", "CPNE1", "CPOX", "CPSF1", "CPT1A", "CPT2", "CRKL", "CRTAP", "CSNK2B", "CSTB", "CTBP1", "CTCF", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTSA", "CTSC", "CUL3", "CUL4B", "CUL7", "CWF19L1", "CXorf56", "CYB5R3", "CYC1", "CYFIP2", "DAG1", "DARS", "DARS2", "DBT", "DCPS", "DCTN1", "DCTN4", "DCXR", "DDB1", "DDOST", "DDRGK1", "DDX3X", "DDX41", "DDX6", "DEGS1", "DGCR8", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHTKD1", "DHX16", "DHX30", "DHX37", "DHX38", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DKC1", "DLAT", "DLD", "DLG1", "DLST", "DNA2", "DNAAF5", "DNAJB11", "DNAJC13", "DNAJC21", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPF2", "DPM1", "DPP9", "DSG2", "DSP", "DST", "DYM", "DYNC1H1", "DYNC2H1", "DYNLL1", "EARS2", "ECE1", "ECHS1", "EDC3", "EED", "EEF1A2", "EEF2", "EFL1", "EFTUD2", "EHHADH", "EHMT1", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF3F", "EIF4A3", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELMO2", "ELP1", "ELP2", "EMC1", "EMD", "EMG1", "EPB41", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERCC3", "ERGIC1", "ERLIN1", "ERLIN2", "ESS2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXOC2", "EXOC6B", "EXOC7", "EXOSC1", "EXOSC2", "EXOSC3", "EXOSC8", "EXOSC9", "EZR", "FAH", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBXO7", "FDFT1", "FDPS", "FDXR", "FECH", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKRP", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FOXRED1", "FRG1", "FSCN1", "FTL", "FTO", "FUCA1", "FUS", "FXR1", "G6PD", "GAA", "GALK1", "GALNT2", "GANAB", "GAPVD1", "GARS", "GATAD2B", "GATB", "GATC", "GBA", "GCDH", "GCLC", "GDAP1", "GDI1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGCX", "GIGYF2", "GINS1", "GIPC1", "GLA", "GLB1", "GLDC", "GLMN", "GLRX5", "GLS", "GLUD1", "GM2A", "GMPPA", "GNAI2", "GNAI3", "GNAO1", "GNPAT", "GNS", "GOSR2", "GOT2", "GPD1L", "GPD2", "GPI", "GPKOW", "GPRASP2", "GPT2", "GRHPR", "GSR", "GSS", "GSTM3", "GTF2I", "GTPBP3", "GUF1", "GUSB", "GYG1", "GYS1", "H2AFY", "HADH", "HADHA", "HADHB", "HARS2", "HAX1", "HCCS", "HCFC1", "HELLS", "HEXA", "HEXB", "HIBCH", "HIST1H1E", "HK1", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HMBS", "HMGA1", "HMGB3", "HMGCL", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B4", "HSPA9", "HSPB1", "HSPD1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFT27", "IFT88", "IGF2BP2", "IGF2R", "IKBKG", "IMPAD1", "IMPDH1", "INF2", "INTS1", "INTS8", "IRF2BPL", "IRS4", "ISCU", "ITPA", "IVD", "JAGN1", "JUP", "KARS", "KDM1A", "KDM3B", "KDSR", "KIAA0319L", "KIF11", "KIF14", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF4A", "KIFBP", "L2HGDH", "LAMB1", "LAMP2", "LAMTOR2", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LEMD2", "LEMD3", "LETM1", "LIPA", "LLGL1", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LNPK", "LONP1", "LRBA", "LRPAP1", "LRPPRC", "LSS", "LZTFL1", "MACF1", "MAGED2", "MAGT1", "MAP1B", "MAP2K1", "MAP2K2", "MAP3K7", "MAPK1", "MAPRE2", "MARS", "MAT2A", "MATR3", "MBOAT7", "MCCC1", "MCCC2", "MCM10", "MCM2", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "MECP2", "MED23", "MESD", "MFF", "MFN2", "MFSD8", "MGME1", "MIA3", "MICU1", "MID1", "MIF", "MINPP1", "MIPEP", "MMAB", "MOGS", "MORC2", "MPG", "MPI", "MRE11", "MRPL12", "MRPL3", "MRPL44", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS28", "MRPS34", "MRPS35", "MRPS7", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MSTO1", "MTAP", "MTCH1", "MTHFD1", "MTHFS", "MTOR", "MTPAP", "MTR", "MTX2", "MUT", "MVD", "MYH14", "MYH9", "MYO6", "NAA10", "NAA15", "NADK2", "NAGLU", "NANS", "NARS", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG2", "NCAPH", "NCDN", "NCSTN", "ND5", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA8", "NDUFA9", "NDUFAF3", "NDUFAF4", "NDUFB10", "NDUFB11", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP1", "NEDD4L", "NEFL", "NEK9", "NEMF", "NF1", "NFS1", "NHLRC2", "NHP2", "NIPBL", "NNT", "NONO", "NOP10", "NOP56", "NPC1", "NPC2", "NPHP3", "NPM1", "NSD1", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSMCE3", "NSUN2", "NT5C2", "NT5C3A", "NUMA1", "NUP107", "NUP133", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP37", "NUP62", "NUP85", "NUP88", "NUP93", "NXN", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OPA1", "OPA3", "OSGEP", "OTULIN", "OXCT1", "P3H1", "P4HB", "PABPN1", "PAFAH1B1", "PALLD", "PARK7", "PARN", "PBRM1", "PC", "PCBD1", "PCCA", "PCCB", "PCK2", "PCNA", "PDCD6", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDK3", "PDSS2", "PDXK", "PEPD", "PEX1", "PEX14", "PEX19", "PFKM", "PFN1", "PGK1", "PGM1", "PGM3", "PHB", "PHF6", "PHGDH", "PHIP", "PI4KA", "PICALM", "PIGG", "PIGK", "PIGS", "PIGT", "PIK3C2A", "PIK3R2", "PISD", "PITRM1", "PLAA", "PLD3", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PMPCA", "PMPCB", "PMVK", "PNP", "PNPLA6", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLE", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR3A", "PON2", "POP1", "POR", "PPA2", "PPIB", "PPIL1", "PPOX", "PPP1CB", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R5D", "PPT1", "PQBP1", "PRCC", "PREPL", "PRKACA", "PRKAR1A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRPF3", "PRPF31", "PRPF4", "PRPF6", "PRPF8", "PRPS1", "PSAT1", "PSMB4", "PSMC3", "PSMD12", "PSPH", "PTCD3", "PTDSS1", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUF60", "PUM1", "PURA", "PUS1", "PUS7", "PXMP2", "PYCR1", "PYCR2", "PYGL", "QARS", "QDPR", "QRSL1", "RAB11B", "RAB18", "RAB23", "RAB3GAP1", "RAB3GAP2", "RAB7A", "RABL3", "RAC1", "RAD21", "RAD50", "RALA", "RANBP2", "RAPGEF2", "RARS", "RASA1", "RBM10", "RBM12", "RBM28", "RBM8A", "RBMX", "RBPJ", "RDH11", "RDX", "REPS1", "RFC1", "RFC2", "RHOA", "RINT1", "RIPK1", "RMND1", "RNASEH2A", "RNASET2", "RNF2", "RPL10", "RPL11", "RPL13", "RPL15", "RPL18", "RPL21", "RPL26", "RPL27", "RPL31", "RPL35", "RPL35A", "RPL5", "RPS10", "RPS14", "RPS15A", "RPS17", "RPS19", "RPS20", "RPS23", "RPS24", "RPS27", "RPS28", "RPS6KA3", "RPS7", "RPSA", "RRAS2", "RRP7A", "RTN2", "SAMHD1", "SARS", "SARS2", "SBDS", "SC5D", "SCAF1", "SCARB2", "SCO1", "SCO2", "SCP2", "SCYL2", "SDHA", "SDHB", "SEC23A", "SEC23B", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC63", "SEPT9", "SERPINB6", "SERPINH1", "SET", "SF3B1", "SF3B4", "SFXN4", "SGPL1", "SH3GL1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SIN3B", "SKIV2L", "SLC12A2", "SLC16A1", "SLC19A1", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC27A4", "SLC2A1", "SLC30A9", "SLC39A14", "SLC44A1", "SLC9A3R1", "SLTM", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC3", "SMCHD1", "SMG8", "SMN1*", "SMPD4", "SMS", "SNAP29", "SNIP1", "SNRNP200", "SNRPE", "SOAT1", "SON", "SORD", "SPART", "SPATA5", "SPECC1L", 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setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Lysosome 27 46 4.536085198408477 5.730803686043728e-06 21.740291262135923 48.609223300970875 0.8281821627988494 0.1302152537326229 7.142313942893836 4.247239237941681 3.086075071395461 0.2389623217115766 4.602280177637758e-17 9.590098126685308e-05 4.092784517441058e-07 1.3922453119695587e-14 1.3139357885669138e-15 +Oxidative phosphorylation 22 62 4.009048796617025 6.0963819216386383e-05 18.79854368932039 59.0752427184466 1.0149760730411637 0.3252836463038503 7.263801581344288 4.652138947381941 1.8018345229041028 0.3643612228552857 5.2750360699546657e-11 7.98760811066247e-06 3.511094645653378e-09 3.6446145272013865e-11 8.404825480003919e-11 +Cardiac muscle contraction 9 22 3.737581312837848 0.0001857990108735 7.728155339805825 19.856796116504853 1.0644813600437804 0.240240383706381 3.4195161605095614 1.765741250102918 1.6465694074711887 0.3002212677564749 7.184885204623578e-06 5.591060906738053e-05 4.066081157623494e-06 9.936897298788151e-07 4.558635539447923e-05 +Parkinsons disease 16 57 3.714115833385351 0.0002039153824422 16.90776699029126 54.04126213592233 1.0315348591123816 0.3152611195514452 7.595108151251147 4.223805209268991 1.8494970521239744 0.3626807692210581 8.464564294180066e-08 2.2265102206353446e-08 2.3243398294928067e-10 2.1987056777748843e-08 4.242628916393788e-07 +Alzheimers disease 15 59 3.4709109246833143 0.0005186960315186 16.135922330097088 58.91990291262136 0.6161331149111849 0.4362889390372475 6.737157569069632 4.882193919366804 1.448905264905826 0.3805753751040122 1.5004908002442156e-05 0.0003693408071895 4.622538066055384e-06 3.405863057254344e-06 6.579857546377014e-05 +Huntingtons disease 16 79 2.9241316389440253 0.0034541863653274 19.631067961165048 76.91504854368932 0.635715043905642 0.4301008974270168 9.08454389027927 5.4148363920790175 1.5734816663041495 0.3870978376334237 5.498047616359947e-06 3.96498410861519e-07 1.67942142783992e-08 2.929644781754218e-06 3.302277331094278e-05 +Sphingolipid metabolism 7 11 2.7079005278674777 0.0067710313338489 5.672330097087379 11.759708737864075 0.9805985471070467 0.1821702203806468 2.452838935293596 1.3449033287601222 1.7625559835482287 0.2542774311591588 0.0003294901345179 0.1114021565620111 0.2147385524083838 0.0028063338575205 1.515921045849114e-05 +Steroid biosynthesis 6 11 2.533126447902172 0.0113050163590997 4.451456310679611 10.919902912621358 0.8535439655720318 0.1867209176898754 2.1463612955879627 1.3314318120676296 1.5430058140543457 0.1933818217769055 8.068313580201978e-06 1.0 1.0 1.31526437712885e-05 1.5533184688236115e-06 +Snare interactions in vesicular transport 10 16 2.472600072837368 0.0134134153621232 5.803398058252427 13.6626213592233 0.8920027438628428 0.3386294703372389 3.103034547770364 2.9171839264116786 1.2201519782198902 0.3219991979242683 0.002167774077166 0.1524760813950871 0.0045096021611559 0.000167417985794 0.0012514150662819 +Porphyrin and chlorophyll metabolism 4 15 2.310555160792299 0.0208574383834516 3.728155339805826 13.315533980582524 1.2215621624941897 0.2689555702886888 1.770547470360957 1.4201912411596824 1.0389071586082248 0.2908939383930566 0.000862192784611 0.0901405579438761 0.0155240337321844 0.0011814468070448 0.00223229240551 +Other glycan degradation 4 6 2.278522035329753 0.0226954931598388 3.966019417475728 7.12378640776699 0.0449593300314452 0.158186848086018 1.7909726921672984 0.8075596903062239 1.9584092358200416 0.2320333335657103 0.0001352921469098 1.0 1.0 0.0435926191526008 0.0003671727016274 +Glycerophospholipid metabolism 6 18 2.263874586599776 0.0235818294046061 5.553398058252427 16.104368932038835 0.8448777148315795 0.3373638196000335 3.045697762577092 2.514285464673758 1.2272389207362138 0.3056726473181033 0.0185112210730873 1.0 1.0 0.0408612650970917 0.0149380445762777 +Glycosaminoglycan degradation 4 6 2.2218195037013286 0.026295506106708 3.407766990291262 5.864077669902913 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@@ +{ + "type_of_task": "ranksum", + "signature_size": 3120, + "annotations_size": 181, + "title": "Average number of proteins per term", + "value": 16.552486187845304 +} \ No newline at end of file diff --git a/msigdb_kegg/paths.json b/msigdb_kegg/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..e560f6a471b1def6cefdca3273789d4f881c4997 --- /dev/null +++ b/msigdb_kegg/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_kegg/fragment/C390/C390_val_log2fc"} \ No newline at end of file diff --git a/msigdb_kegg/result.tsv b/msigdb_kegg/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..e68e8ab113e8b2b637d550c0a530a7363b6ff841 --- /dev/null +++ b/msigdb_kegg/result.tsv @@ -0,0 +1,70 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Lysosome 0.7563702767889194 4.536085198408477 5.730803686043728e-06 0.0010367406520772 0.000518637733587 46 O14773,Q9Y487,O15118,P04062,P11279,P11117,P06280,Q14108,Q13510,P50897,Q15904,O75503,P17900,Q9NZJ7,Q93050,P20645,P10619,P08236,Q9UMR5,P13473,P38571,P04066,P16278,P15586,P54802,Q8NCC3,P06865 27 +Oxidative phosphorylation 0.6070287270221497 4.009048796617025 6.0963819216386383e-05 0.0109741277020347 0.0036781504260553 62 Q9Y487,Q9UDW1,O14949,Q7KZN9,O75964,P13073,P14406,P24539,P14927,O95169,Q86Y39,P21912,O96000,P00846,Q15904,P20674,P22695,Q9Y6M9,Q93050,P56385,P00403,O95168 22 +Cardiac muscle contraction 0.7879386922656574 3.737581312837848 0.0001857990108735 0.0330734524655802 0.0073817368444092 22 P13073,P16615,P14406,P20674,P05023,P22695,Q9UDW1,O14949,P00403 9 +Parkinsons disease 0.6015487004274235 3.7141158333853506 0.0002039153824422 0.036239489047453 0.0073817368444092 57 P13073,P14406,P20674,P24539,O95169,P45880,P22695,Q9Y6M9,Q9UDW1,P21912,Q9Y277,O96000,O14949,P21796,P00846,P00403 16 +Alzheimers disease 0.5656188141430452 3.4709109246833143 0.0005186960315186 0.089633796281289 0.0156473302841463 59 P13073,P16615,P14406,P24539,O95169,P20674,Q92542,P22695,Q9Y6M9,Q9UDW1,P21912,O96000,O14949,P00846,P00403 15 +Huntingtons disease 0.5053292029002429 2.9241316389440253 0.0034541863653274 0.4654286227086989 0.0781509665155338 79 P13073,P14406,P20674,P24539,O95169,P45880,P22695,Q9Y6M9,Q9UDW1,P21912,Q9Y277,O96000,O14949,P21796,P00846,P00403 16 +Sphingolipid metabolism 0.7840720534307636 2.7079005278674777 0.0067710313338489 0.7076269248742777 0.0942735901097428 11 P06280,Q13510,O95470,Q06136,P04062,P16278,O15269 7 +Steroid biosynthesis 0.7502586155381122 2.5331264479021716 0.0113050163590997 0.8722732528494438 0.1203651741762973 11 P38571,Q14534,Q16850,Q15800,P37268,O75845 6 +Snare interactions in vesicular transport 0.6591056624883049 2.4726000728373676 0.0134134153621232 0.9132094904135296 0.122947925024216 16 O15400,Q9P2W9,O60499,O95249,O95721,O43752,Q12846,O75396,Q13190,Q12981 10 +Porphyrin and chlorophyll metabolism 0.6448850630881924 2.310555160792299 0.0208574383834516 0.977964995221164 0.1572998478085313 15 Q7KZN9,P30519,P09601,P22830 4 +Other glycan degradation 0.8326536799228692 2.2785220353297535 0.0226954931598388 0.9843176126762032 0.1641658123936045 6 P04062,P16278,P04066,P06865 4 +Glycerophospholipid metabolism 0.6003385106440955 2.2638745865997754 0.0235818294046061 0.9866927181208864 0.1641658123936045 18 Q96N66,Q8NF37,P35790,Q9UG56,Q9BVG9,Q8NCC3 6 +Glycosaminoglycan degradation 0.8199280837256331 2.2218195037013286 0.026295506106708 0.991958842573902 0.1762772816783021 6 P06865,P16278,P15586,P54802 4 +Cell adhesion molecules cams 0.6479259769426284 2.0563287826282273 0.0397508357609701 0.9993521227202624 0.2119651467612584 12 Q92896,P04439,P10321,Q16625,P05556,Q5ZPR3,P10586 7 +Calcium signaling pathway 0.5787871735614268 1.9670114367542753 0.0491818922892419 0.9998914481167904 0.2342611185355999 16 P16615,P12235,P20020,P45880,P23634,Q9Y277,P21796 7 +Hypertrophic cardiomyopathy hcm 0.6309912766081458 1.8854159674633468 0.0593736999180163 0.9999845652971316 0.2644990978421188 11 P16615,P05556,Q14118,P02545,P50402 5 +N glycan biosynthesis 0.5473231372151314 1.830195133809356 0.0672207651974445 0.9999966117506476 0.2644990978421188 17 O60476,Q9BT22,Q9H6U8,P46977,Q86YN1,Q9BV10 6 +Renin angiotensin system 0.828323722784959 1.80706984821588 0.0707513891938638 0.9999982943983288 0.2724681158316883 4 P10619 1 +Aldosterone regulated sodium reabsorption 0.6533294395107876 1.7152478083264435 0.0862998029916422 0.9999999195598156 0.3124052868297447 8 P05026,P05023,O00459,P27361 4 +Vibrio cholerae infection 0.4959835423119116 1.620340322262989 0.1051591917014271 0.999999998155042 0.3398895303206843 19 Q93050,Q9Y487,P24390 3 +Gap junction 0.5085062193461848 1.5644987984586027 0.1177004749271053 0.9999999998566148 0.3700694194306372 17 P04899,Q13885,P27361,Q9BVA1,P07437,P62993,P04350,Q9BUF5,P68371 9 +Glycosphingolipid biosynthesis lacto and neolacto series 0.9393842206542696 1.546899778162004 0.121887414574374 0.9999999999393842 0.3739257972535881 2 O43505 1 +Dilated cardiomyopathy 0.5868568847830374 1.535997792215328 0.1245389218266934 0.9999999999649354 0.3739806701783907 10 P16615,P05556,Q14118,P02545,P50402 5 +Riboflavin metabolism 0.6950673613882612 1.5228077762846453 0.1278068038980366 0.9999999999821804 0.3739806701783907 5 Q9NPH0 1 +Abc transporters 0.9054809490010516 1.4667231401015344 0.1424513853740832 0.9999999999991686 0.4015094065583797 3 O75027 1 +Steroid hormone biosynthesis 0.9185375240538888 1.4603698261181852 0.1441884609187551 0.999999999999424 0.4015094065583797 2 P21964 1 +Glycosylphosphatidylinositol gpi anchor biosynthesis 0.7406931964056306 1.433514950682874 0.1517107294277724 0.9999999999998834 0.406832178460234 4 Q5H8A4,Q92643,Q96S52 3 +Glycosaminoglycan biosynthesis heparan sulfate 0.90923669018603 1.421777959381279 0.1550907199655005 0.9999999999999434 0.406832178460234 2 Q7LGA3 1 +Glycosaminoglycan biosynthesis chondroitin sulfate 0.9092366901860276 1.421777959381268 0.1550907199655036 0.9999999999999434 0.406832178460234 2 Q8NCH0 1 +Protein export 0.5150268967137818 1.405806133072251 0.1597817003744517 0.9999999999999792 0.4125812357822782 14 Q15005,Q15070,Q99442,Q9Y5M8 4 +Amyotrophic lateral sclerosis als 0.5608909372000004 1.3892168870884951 0.164766808124924 0.999999999999993 0.4125812357822782 10 P07196,Q9BUN8,O96008 3 +Glycerolipid metabolism 0.5066203509631579 1.2809748186228636 0.2002025110660747 1.0 0.4529581812869942 13 P06280,P51648,Q53H12 3 +O glycan biosynthesis 0.8415939575130045 1.216871015728178 0.2236532949502181 1.0 0.4928391211455537 3 O43505 1 +Proximal tubule bicarbonate reclamation 0.5574096276639502 1.2107322190348997 0.2259980500280716 1.0 0.4928391211455537 8 Q9UBX3 1 +Arrhythmogenic right ventricular cardiomyopathy arvc 0.4803619981754791 1.1805346811442523 0.2377876252710633 1.0 0.506347766753676 14 P16615,Q14118,P50402,P02545 4 +Glycosphingolipid biosynthesis ganglio series 0.80558229066409 1.076936892308486 0.2815084600194968 1.0 0.578776065734115 3 P06865,P16278 2 +Glycosphingolipid biosynthesis globo series 0.8055822906640893 1.076936892308484 0.2815084600194977 1.0 0.578776065734115 3 P06280,P06865 2 +Epithelial cell signaling in helicobacter pylori infection 0.4221806805718309 1.0700616802220964 0.2845915461344543 1.0 0.578776065734115 19 Q93050,Q9Y487 2 +Galactose metabolism 0.4577592518479721 0.970934456587583 0.3315809183867144 1.0 0.6510092328987054 13 P06280,P16278,P52789 3 +Nicotinate and nicotinamide metabolism 0.5736633070441945 0.9587315430555328 0.337694003639962 1.0 0.6510092328987054 5 Q13423 1 +Fatty acid metabolism 0.3756730083599152 0.9579396469200648 0.3380931927761232 1.0 0.6510092328987054 29 P51648,P30837,Q9BWD1,P23786,P50416 5 +Biosynthesis of unsaturated fatty acids 0.4688479612175004 0.9341106614591332 0.3502468129488567 1.0 0.660361178580657 11 Q9BY49,Q15067,Q53GQ0 3 +Phosphatidylinositol signaling system 0.4448555189692768 0.790636404882085 0.429156196504125 1.0 0.737583937110364 11 Q10713,Q96PE3,O95674,O00459 4 +Folate biosynthesis 0.5666204917849748 0.6916737723433004 0.4891422213933629 1.0 0.7880771833551297 4 P00374 1 +Ecm receptor interaction 0.5142440468212042 0.6876776702393094 0.4916557847495948 1.0 0.7880771833551297 5 Q08722,Q14118 2 +Viral myocarditis 0.4181588748118716 0.6733698535434031 0.5007120225737012 1.0 0.7880771833551297 12 P10321,P04439,Q14118,P78310 4 +Alpha linolenic acid metabolism 0.6920115495668939 0.6530514614025452 0.513723102759756 1.0 0.8015851862027227 3 O15254,Q15067 2 +Graft versus host disease 0.547105334944171 0.6133253630155909 0.5396612261910922 1.0 0.8139890161715642 4 P10321,P04439 2 +Allograft rejection 0.547105334944171 0.6133253630155909 0.5396612261910922 1.0 0.8139890161715642 4 P10321,P04439 2 +Autoimmune thyroid disease 0.547105334944171 0.6133253630155909 0.5396612261910922 1.0 0.8139890161715642 4 P10321,P04439 2 +Primary bile acid biosynthesis 0.6962796664528514 0.5818921571416146 0.5606393235954286 1.0 0.8216135691827197 2 P22307 1 +Ascorbate and aldarate metabolism 0.4667846938866916 0.5503591713482968 0.5820730466994235 1.0 0.8230876675984036 6 P51648 1 +Peroxisome 0.3238734834334587 0.5175891369621823 0.6047449626160963 1.0 0.8419910633347187 30 Q13011,Q9NR77,O75381,Q9BY49,P40855,O00116,Q15067 7 +Limonene and pinene degradation 0.4236199385986338 0.5042407542717011 0.6140922048456088 1.0 0.8484785425729403 8 P51648 1 +Histidine metabolism 0.4156513888098022 0.4645021646933678 0.6422880089778842 1.0 0.860467806273391 8 P51648 1 +Terpenoid backbone biosynthesis 0.3845771968030669 0.4401248268087933 0.659846701520711 1.0 0.8658771730669208 11 O95749,Q9BWD1 2 +Arachidonic acid metabolism 0.6228863354999541 0.4237163913570471 0.6717726595941573 1.0 0.8685060813324462 3 Q9H7Z7 1 +Antigen processing and presentation 0.3537650793697325 0.4060048873698137 0.6847390093659262 1.0 0.8728011316565679 15 P10321,P04439,P27824,Q9UL46,P61289 5 +Type i diabetes mellitus 0.4336710507631354 0.3504134896950913 0.7260284040779394 1.0 0.8991399313176385 5 P10321,P04439 2 +Ppar signaling pathway 0.3384534575703582 0.3363921403023263 0.7365751756375267 1.0 0.9008115323675158 16 P23786,P50416 2 +Tryptophan metabolism 0.3306591972740451 0.2872796308409616 0.7738982178531371 1.0 0.903051805355574 16 P51648,Q9BWD1 2 +Basal transcription factors 0.3811410480668269 0.1961313048537409 0.8445073943480508 1.0 0.9578106970232904 6 P29083 1 +Vasopressin regulated water reabsorption 0.311353393461825 0.1933517642639849 0.8466834890813617 1.0 0.9578106970232904 17 Q15907,Q13561 2 +Butanoate metabolism 0.3013190167619873 0.1851875344842146 0.8530819460300261 1.0 0.95905485858034 19 P51648,Q9BWD1 2 +Type ii diabetes mellitus 0.3365641223286066 0.1562716003616344 0.8758189409214587 1.0 0.978538446338173 10 O00459,P27361,P52789 3 +Lysine degradation 0.2830348606292999 0.1189219185121926 0.9053372165255786 1.0 0.9942409782451638 26 P51648,P30837,Q9BWD1 3 +Starch and sucrose metabolism 0.3109116314411944 0.1008535334763104 0.9196667298705974 1.0 1.0 13 P08236,P52789 2 +Endometrial cancer 0.3000963023957719 0.0501828142222954 0.9599767065613178 1.0 1.0 13 P27361,O00459,P62993,P25054,P31751 5 +Endocytosis 0.262182756214063 0.0233030824677183 0.9814085129289732 1.0 1.0 49 P04439,P10321,Q92783,Q8N6T3,Q9Y3E7,Q9Y371,Q9H4M9,Q9H223,P02786,Q9H9H4,Q15907,Q9UQN3,P61020 13 diff --git a/msigdb_kegg/selections.json b/msigdb_kegg/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..886d9d5b3a1249cbd91b66317d91796892b6ad48 --- /dev/null +++ b/msigdb_kegg/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Abc transporters", "Acute myeloid leukemia", "Adherens junction", "Adipocytokine signaling pathway", "Alanine aspartate and glutamate metabolism", "Aldosterone regulated sodium reabsorption", "Allograft rejection", "Alpha linolenic acid metabolism", "Alzheimers disease", "Amino sugar and nucleotide sugar metabolism", "Aminoacyl trna biosynthesis", "Amyotrophic lateral sclerosis als", "Antigen processing and presentation", "Apoptosis", "Arachidonic acid metabolism", "Arginine and proline metabolism", "Arrhythmogenic right ventricular cardiomyopathy arvc", "Ascorbate and aldarate metabolism", "Autoimmune thyroid disease", "Axon guidance", "B cell receptor signaling pathway", "Basal cell carcinoma", "Basal transcription factors", "Base excision repair", "Beta alanine metabolism", "Biosynthesis of unsaturated fatty acids", "Bladder cancer", "Butanoate metabolism", "Calcium signaling pathway", "Cardiac muscle contraction", "Cell adhesion molecules cams", "Cell cycle", "Chemokine signaling pathway", "Chronic myeloid leukemia", "Circadian rhythm mammal", "Citrate cycle tca cycle", "Colorectal cancer", "Cysteine and methionine metabolism", "Cytokine cytokine receptor interaction", "Cytosolic dna sensing pathway", "Dilated cardiomyopathy", "Dna replication", "Dorso ventral axis formation", "Drug metabolism cytochrome p450", "Drug metabolism other enzymes", "Ecm receptor interaction", "Endocytosis", "Endometrial cancer", "Epithelial cell signaling in helicobacter pylori infection", "Erbb signaling pathway", "Ether lipid metabolism", "Fatty acid metabolism", "Fc epsilon ri signaling pathway", "Fc gamma r mediated phagocytosis", "Focal adhesion", "Folate biosynthesis", "Fructose and mannose metabolism", "Galactose metabolism", "Gap junction", "Glioma", "Glutathione metabolism", "Glycerolipid metabolism", "Glycerophospholipid metabolism", "Glycine serine and threonine metabolism", "Glycolysis gluconeogenesis", "Glycosaminoglycan biosynthesis chondroitin sulfate", "Glycosaminoglycan biosynthesis heparan sulfate", "Glycosaminoglycan biosynthesis keratan sulfate", "Glycosaminoglycan degradation", "Glycosphingolipid biosynthesis ganglio series", "Glycosphingolipid biosynthesis globo series", "Glycosphingolipid biosynthesis lacto and neolacto series", "Glycosylphosphatidylinositol gpi anchor biosynthesis", "Glyoxylate and dicarboxylate metabolism", "Gnrh signaling pathway", "Graft versus host disease", "Hedgehog signaling pathway", "Hematopoietic cell lineage", "Histidine metabolism", "Homologous recombination", "Huntingtons disease", "Hypertrophic cardiomyopathy hcm", "Inositol phosphate metabolism", "Insulin signaling pathway", "Jak stat signaling pathway", "Leishmania infection", "Leukocyte transendothelial migration", "Limonene and pinene degradation", "Long term depression", "Long term potentiation", "Lysine degradation", "Lysosome", "Mapk signaling pathway", "Maturity onset diabetes of the young", "Melanogenesis", "Melanoma", "Metabolism of xenobiotics by cytochrome p450", "Mismatch repair", "Mtor signaling pathway", "N glycan biosynthesis", "Natural killer cell mediated cytotoxicity", "Neuroactive ligand receptor interaction", "Neurotrophin signaling pathway", "Nicotinate and nicotinamide metabolism", "Nitrogen metabolism", "Nod like receptor signaling pathway", "Non homologous end joining", "Non small cell lung cancer", "Notch signaling pathway", "Nucleotide excision repair", "O glycan biosynthesis", "Olfactory transduction", "One carbon pool by folate", "Oocyte meiosis", "Other glycan degradation", "Oxidative phosphorylation", "P53 signaling pathway", "Pancreatic cancer", "Pantothenate and coa biosynthesis", "Parkinsons disease", "Pathogenic escherichia coli infection", "Pathways in cancer", "Pentose and glucuronate interconversions", "Pentose phosphate pathway", "Peroxisome", "Phenylalanine metabolism", "Phosphatidylinositol signaling system", "Porphyrin and chlorophyll metabolism", "Ppar signaling pathway", "Primary bile acid biosynthesis", "Primary immunodeficiency", "Prion diseases", "Progesterone mediated oocyte maturation", "Propanoate metabolism", "Prostate cancer", "Proteasome", "Protein export", "Proximal tubule bicarbonate reclamation", "Purine metabolism", "Pyrimidine metabolism", "Pyruvate metabolism", "Regulation of actin cytoskeleton", "Regulation of autophagy", "Renal cell carcinoma", "Renin angiotensin system", "Retinol metabolism", "Riboflavin metabolism", "Ribosome", "Rig i like receptor signaling pathway", "Rna degradation", "Rna polymerase", "Selenoamino acid metabolism", "Small cell lung cancer", "Snare interactions in vesicular transport", "Sphingolipid metabolism", "Spliceosome", "Starch and sucrose metabolism", "Steroid biosynthesis", "Steroid hormone biosynthesis", "Sulfur metabolism", "Systemic lupus erythematosus", "T cell receptor signaling pathway", "Taste transduction", "Terpenoid backbone biosynthesis", "Tgf beta signaling pathway", "Thyroid cancer", "Tight junction", "Toll like receptor signaling pathway", "Tryptophan metabolism", "Type i diabetes mellitus", "Type ii diabetes mellitus", "Tyrosine metabolism", "Ubiquitin mediated proteolysis", "Valine leucine and isoleucine biosynthesis", "Valine leucine and isoleucine degradation", "Vascular smooth muscle contraction", "Vasopressin regulated water reabsorption", "Vegf signaling pathway", "Vibrio cholerae infection", "Viral myocarditis", "Wnt signaling pathway"], "available_proteins": ["AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCB7", "ABCD3", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN4", "ADA", "ADAR", "ADH5", "ADI1", "ADK", "ADSL", "ADSS", "AFDN", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AIFM1", "AK1", "AK2", "AK4", "AKR1A1", "AKR1B1", "AKT2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALG9", "ALYREF", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APC", "APEX1", "APRT", "AQR", "ARFGAP1", "ARG2", "ARHGDIA", "ARHGEF2", "ARHGEF7", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASNA1", "ASNS", "ATG3", "ATG4B", "ATIC", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "AURKA", "B3GALT6", "B4GAT1", "BAIAP2", "BCAS2", "BCL10", "BIRC6", "BLVRA", "BLVRB", "BNIP1", "BPNT1", "BRCA1", "BUB1B", "BUB3", "BUD23", "BUD31", "CAB39", "CACYBP", "CAD", "CALD1", "CALR", "CAMK2D", "CAMK2G", "CANX", "CAPN1", "CAPN2", "CARS", "CARS2", "CASK", "CBR1", "CCDC12", "CCDC6", "CCNB1", "CD276", "CD47", "CDC23", "CDC27", "CDC42", "CDC5L", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK7", "CDS2", "CETN2", "CFL1", "CFL2", "CHD8", "CHEK2", "CHERP", "CHKA", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHORDC1", "CHP1", "CHST14", "CKB", "CKMT1A*", "CLN5", "CLTA", "CLTB", "CLTC", "CMAS", "CMPK1", "CNOT1", "CNOT3", "CNOT7", "CNOT9", "COASY", "COMT", "COX11", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7A2L", "COX7C", "CPOX", "CPT1A", "CPT2", "CRK", "CRKL", "CRNKL1", "CS", "CSK", "CSNK1A1", "CSNK1E", "CSNK2A2", "CSNK2B", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUL7", "CXADR", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DARS", "DARS2", "DBT", "DCP1B", "DCPS", "DCTN1", "DCTN2", "DCTN4", "DCXR", "DDB1", "DDOST", "DDX23", "DDX39B", "DDX3X", "DDX42", "DDX46", "DDX5", "DDX6", "DEGS1", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHX15", "DHX16", "DHX38", "DHX8", "DIAPH1", "DIAPH2", "DIAPH3", "DIS3", "DLAT", "DLD", "DLG1", "DLST", "DNA2", "DNM1L", "DNM2", "DNMT1", "DOCK1", "DOLPP1", "DPM1", "DPYSL2", "DSG2", "DSP", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EEA1", "EFTUD2", "EHD1", "EHD4", "EHHADH", "EHMT1", "EHMT2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "ELOB", "ELOC", "EMD", "ENAH", "ENDOD1", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPRS", "EPS15", "ERCC3", "ERO1A", "EXO1", "EXOC4", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FADS2", "FAH", "FAR1", "FARP2", "FARSA", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FECH", "FEN1", "FH", "FLAD1", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FUCA1", "FUCA2", "G6PD", "GAA", "GABARAPL2", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GARS", "GART", "GBA", "GCAT", "GCDH", "GCLC", "GFPT1", "GGA2", "GGCT", "GGH", "GGPS1", "GLA", "GLB1", "GLDC", "GLG1", "GLO1", "GLS", "GLUD1", "GM2A", "GMPPA", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAO1", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOSR1", "GOSR2", "GOT1", "GOT2", "GPAT4", "GPD1L", "GPD2", "GPI", "GPT2", "GRB2", "GRHPR", "GSK3A", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2H4", "GTF2I", "GUSB", "GYS1", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD2", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HCCS", "HDAC1", "HDAC2", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HMBS", "HMGB1", "HMGCL", "HMGCR", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA3", "HNRNPC", "HNRNPK", "HNRNPM", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HTRA2", "HTT", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IGF2BP1", "IGF2R", "IKBKG", "IMPDH1", "IMPDH2", "INPP4A", "IQGAP1", "IQGAP2", "IQGAP3", "IRS4", "ISYNA1", "ITGAV", "ITGB1", "ITPA", "IVD", "JUP", "KARS", "KDELR1", "KDSR", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAP3", "LARS", "LARS2", "LCLAT1", "LCMT2", "LDHA", "LDHB", "LIG1", "LIG3", "LIPA", "LLGL1", "LMNA", "LNPEP", "LPCAT1", "LSM2", "LSM4", "LSM6", "LSS", "LTA4H", "LYPLA1", "LYPLA2", "M6PR", "MAD2L1", "MAN1A1", "MAN1A2", "MAN2A1", "MAP2K1", "MAP2K2", "MAP3K7", "MAPK1", "MAPK14", "MAPK3", "MARS", "MAT2A", "MAT2B", "MAVS", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "ME1", "ME2", "MFSD8", "MGST2", "MGST3", "MID1", "MIF", "MINPP1", "MMAB", "MOGS", "MPG", "MPI", "MPST", "MRE11", "MRPL13", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTAP", "MTCH1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTOR", "MTR", "MUT", "MVD", "MYH10", "MYH14", "MYH9", "MYL6", "NAE1", "NAGLU", "NAMPT", "NANS", "NARS", "NBN", "NCBP1", "NCKAP1", "NCL", "NCSTN", "ND5", "NDUFA10", "NDUFA11", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFB10", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS5", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEDD4L", "NEFL", "NEFM", "NF1", 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chemiosmotic coupling and heat production by uncoupling proteins 29 66 4.3122708956017854 1.615862835557813e-05 20.8373786407767 62.38106796116505 0.8350130317954786 0.3584533980641267 8.974357262450994 5.887120286458052 1.9056004199022172 0.3784220720284639 6.016691783396405e-10 0.0002025840945074 1.5760678950066837e-06 2.2281726275077488e-09 2.045565847869202e-10 +Protein localization 38 70 4.162326583130863 3.150213670255475e-05 25.97087378640777 74.18203883495146 1.5594110758345356 0.2555609300308859 10.717199959161563 6.26233677332747 2.0947329132902324 0.3569924888492793 1.1634923943003823e-09 0.0005165575391543 8.408639046500143e-06 0.0001615199896828 9.082686089871246e-13 +Mitochondrial protein import 23 34 3.9713213474007736 7.147509037341848e-05 13.468446601941748 34.5873786407767 1.6025718162972953 0.1874419874946837 6.078090089851624 2.2108812815475147 1.8878681708577505 0.2901223460226844 5.0770810280882246e-09 0.0001627366612638 8.081545244431965e-08 1.0496856898956417e-05 1.733958957496337e-12 +Respiratory electron transport 24 56 3.768773204397673 0.0001640518599443 17.473300970873787 52.5752427184466 0.7619430018929745 0.3962973483509951 7.757662405441163 5.39117119769307 1.7039672197087123 0.3858226471737118 6.18356927335005e-08 0.011820001819681 0.0004105222060924 1.240657445286451e-07 6.160825320165407e-08 +Cristae formation 13 20 3.528268326902923 0.0004182879143885 8.475728155339805 19.805825242718445 0.8613288847471563 0.2756396593916832 3.7825471979528897 1.2052333490949263 1.5890526548766304 0.3070386069824295 2.1873531614578627e-09 0.0070670490819082 0.0001188562693173 1.5303782725270384e-07 7.653552305573563e-11 +Sphingolipid metabolism 11 24 3.4804536434030298 0.0005005654386662 11.00242718446602 26.135922330097088 1.1708540815039898 0.1757583754913391 4.192861933829232 2.1968580551223003 2.1941615995620167 0.2567064655985949 4.1103559978505625e-06 0.0343104139968933 0.0029226642017144 1.5911917429603794e-05 1.1385048622082954e-06 +Glycosaminoglycan metabolism 10 15 3.22823388545232 0.0012455708952676 6.563106796116505 14.388349514563108 0.750167459040055 0.1742505874253542 2.387954817808654 2.3973407990867264 1.8682770414846892 0.2409021330213527 7.929017128492354e-05 0.2821140734917597 0.029653655190088 0.00143626842716 0.0005068238920592 +Slc mediated transmembrane transport 16 24 3.2062389419163515 0.0013448226813597 8.672330097087379 21.910194174757283 1.4735742044813558 0.239038892478899 4.348519601656105 3.146764860695784 1.3934177975338422 0.3068823132077037 0.0445849506071332 1.0 0.2533609509960167 0.0110026098329487 0.1171354495730309 +Mitochondrial biogenesis 12 35 3.1364628156041405 0.0017099911944147 10.572815533980584 33.521844660194176 0.7125383902440768 0.3998427377933914 4.798567629623383 2.9315837025395943 1.2191838320541302 0.3355715376706868 0.0004615704110777 0.0605318649589048 0.0089732445190698 0.0009941384248502 0.0002122388464955 +Glycosphingolipid metabolism 8 15 3.048144484649969 0.0023025918797343 7.514563106796117 15.521844660194176 0.6340330218232789 0.1371235236408302 2.3948329397108954 1.2175929202976112 2.2116324239586063 0.2290247571497847 3.3563825602883177e-06 0.1444128696349771 0.0038117145357013 1.0920782304657888e-05 2.2380734395490096e-06 +Diseases of glycosylation 9 18 3.040881277792431 0.0023588682202675 6.359223300970874 19.17718446601942 0.13180823173309 0.3045208720095976 2.4657040544471793 2.991113672999948 1.5111068586159069 0.284004628008759 0.0007272183063627 1.0 0.0365585180593606 0.0363101363561639 0.003548440361811 +Mitochondrial calcium ion transport 14 17 3.0194948215783364 0.0025319662142497 6.502427184466019 16.12135922330097 1.0650233237312683 0.2089377868120644 3.410790121717641 1.246287729205551 1.626144580445205 0.28031724173526 6.794343290026404e-07 0.0001227133929992 4.236608354872846e-05 0.0001164002838048 2.4286062180741856e-07 +Glycerophospholipid biosynthesis 11 31 3.003806606958085 0.0026662474586311 9.439320388349516 29.58009708737864 1.1800609247564997 0.3081196451067344 4.809346434845489 4.094857299253986 1.3402414818469337 0.3224557628717913 0.0019062750394601 0.3347057085815983 0.5657328567415809 0.0010737250984011 0.0008638998624017 +Phospholipid metabolism 25 47 2.994159249540332 0.0027520226362358 12.859223300970871 45.932038834951456 1.017004520648936 0.3949296504793965 6.241466981115118 7.362344677079641 1.3242274243570669 0.3709328103546776 0.0083279047002175 0.5237470911105582 0.4440550029604954 0.0044922754835291 0.0037129738591824 +Ion channel transport 12 28 2.899729521642601 0.0037348479263294 9.031553398058252 27.74271844660194 0.8980727715308076 0.3472480807052641 4.2752930421976005 3.4432740668393595 1.4212023690700646 0.3452897078102002 7.75800330461835e-05 1.0 0.5484830827387088 0.0141287190006936 0.000146373457931 +The citric acid tca cycle and respiratory electron transport 34 98 2.787835497150958 0.0053061480216023 27.99757281553398 94.17961165048544 0.4883573568636233 0.4259472248586306 12.60942373482268 7.020896123249261 1.7895370613076145 0.38969273744301 5.654609091863182e-10 9.674628701796708e-05 2.924746450374719e-06 1.473366242224771e-09 5.857555286089111e-10 +Metabolism of porphyrins 3 10 2.70110784706242 0.0069108925050072 2.766990291262136 9.186893203883496 1.2638611374915407 0.2204767139400954 1.3861582272503026 1.170645435718008 1.0950295956895657 0.2541910601955712 0.0036978306683598 0.0771453392642774 0.0113213926532688 0.0006143549700213 0.0078812527225172 +Selective autophagy 13 32 2.6475409693544254 0.0081079534686949 7.315533980582524 31.50728155339806 0.9304065525388932 0.4028226131520862 3.350474746292583 3.101431769008479 1.074438805028982 0.3502038092942861 0.0002585239163693 0.0037980660192356 0.0038718963398175 0.0780890051531907 0.001360170383234 +Pre notch processing in golgi 3 5 2.5773762748090885 0.0099553514194754 1.5024271844660195 3.699029126213592 0.5380633584805332 0.3184867450195059 0.954037883698991 1.0620090089420116 1.311360861985417 0.2898512190860777 0.0012582535978488 0.0595353304203936 0.1180585699575878 0.0001991597833083 0.0027630263410089 +Rnd2 gtpase cycle 8 18 2.552800822996888 0.0106860585577048 4.393203883495145 16.434466019417474 0.2153574081682165 0.5011395656561803 2.3985740964780717 2.430205644003464 0.9415381736607308 0.282984964314256 0.0192756122743752 0.0151070197534971 0.0065760397653667 0.0713646261968556 0.0028137185393519 +Pink1 prkn mediated mitophagy 6 9 2.537468362102483 0.0111657460053888 3.2815533980582523 8.473300970873787 1.395617281862234 0.1554977461962819 1.6230588150315317 0.9738153254376878 1.3577427922485954 0.2414588001366878 0.0003792915561059 6.357667188483331e-05 1.7352123755419733e-05 0.0006143549700213 0.0010053263520343 +Processing of smdt1 10 12 2.4588655517510247 0.0139376802944106 4.975728155339806 11.155339805825244 0.3833102568885913 0.3649000478471426 2.609615007852169 1.2287595888742628 1.3301610577177632 0.3259664414506655 0.002916997936102 1.0 0.1432798584585485 0.0557098434243155 0.0007388687073799 +Mitophagy 6 12 2.402234720135214 0.0162952488479035 3.662621359223301 11.783980582524272 1.3564301304992197 0.1917930287367771 1.8155907654273165 1.3363606860118669 1.2723890100166135 0.2636913304405313 0.0020770051311059 0.0001849020150097 7.357256485958134e-05 0.0024022577840735 0.0052134507581354 +Keratan sulfate keratin metabolism 4 6 2.387588866077298 0.0169593020684579 3.1359223300970873 5.439320388349515 0.1148000450757159 0.1857420338858874 1.294488268568909 0.7592200419566036 1.8452752770630356 0.2520366769461069 0.0003792915561059 1.0 0.1515272625734178 0.0073447144383531 0.0010053263520343 +Heparan sulfate heparin hs gag metabolism 4 5 2.377813868605584 0.0174156143905361 2.4320388349514563 4.83252427184466 0.8003221575390526 0.2230961855611341 1.2648123228701085 1.2708877857521428 1.4628061886044337 0.2633127679646707 0.0076104440684934 0.1403531442218371 0.266209970857853 0.0411512789917762 0.0179733508374719 +Ion transport by p type atpases 7 13 2.3500517415164506 0.0187708015704481 3.7305825242718447 10.33980582524272 0.407323607098393 0.3519804201795568 2.374569281431047 1.6883576098110384 1.2891970822622851 0.3108388098264688 0.0001575755588906 1.0 1.0 0.0379489226270714 8.543393326442053e-05 +Formation of atp by chemiosmotic coupling 4 10 2.319453866142765 0.0203704398261763 3.5898058252427183 9.805825242718448 0.4783111855246443 0.2899716869602585 2.2195497140568734 0.9063771094889388 1.382334358445268 0.2713732710506487 0.0017074381782845 0.0019049706229129 0.0002902447274798 0.0041470760753771 0.0003671727016274 +Diseases associated with n glycosylation of proteins 2 5 2.2550939701477604 0.0241274310532864 2.2475728155339807 5.725728155339806 0.3341088995719526 0.3985277581822796 1.5924179977786468 1.7320559095113808 1.1764326310317936 0.3016026507368399 0.0315532322883059 1.0 1.0 0.3559534457378639 0.0539281835546241 +Transport of small molecules 73 150 2.235513744218952 0.0253836403279124 41.730582524271846 151.96601941747574 1.4265613612661356 0.380396759556163 14.87709311863932 12.598305121005488 1.746958952072276 0.4128488770716938 2.452264310440771e-09 0.0081118908691198 0.0032793156510341 2.9035182763147562e-08 1.9178334855305287e-09 +Class i peroxisomal membrane protein import 5 8 2.209272427463614 0.0271556978067528 4.300970873786408 9.604368932038836 1.1426576411245968 0.2560233101944223 2.515331441636984 1.9424437465598188 1.2133199793435778 0.2911424942178205 0.0364081996833034 0.0858288536093336 0.1677870330809631 0.3715199079432311 0.0118865434534573 +Cholesterol biosynthesis 8 18 2.201137630587459 0.0277262820013051 5.878640776699029 16.75 1.3996798653689082 0.2350718901934974 2.503362805703168 1.8986773628384943 1.0886216368414 0.270950573691616 2.630958324992287e-05 1.0 1.0 1.734109635655837e-05 9.47697315695096e-07 +Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 7 16 2.1952804690345338 0.0281434850373725 6.014563106796117 17.274271844660195 0.870961683103299 0.329566970411291 2.8591161566949044 2.4465188670593117 1.2657234914365352 0.3108311955329007 0.0218089356051038 0.0284424316807039 0.1009015630926116 0.0457432535763689 0.0180126260897142 +Pre notch expression and processing 3 12 2.192435007447453 0.0283481111809476 2.995145631067961 10.555825242718448 -0.0894814299313095 0.5026529390817477 1.6937852502419612 1.5561622099989527 0.9592276843174942 0.29030663508473 0.1318028379325091 0.2106238865638343 0.3837329617110586 0.03203241935523 0.2236139420972091 +Organelle biogenesis and maintenance 31 98 2.1389009466413293 0.0324436913753753 25.364077669902912 93.59466019417476 0.8635708484684039 0.4952956395971041 8.486338013959335 9.495950625534562 1.0729913690397648 0.3929655478972317 0.0001373826709397 0.3609760194684275 0.0441471348315453 0.0291492250803966 0.0001047927224537 +Depolymerisation of the nuclear lamina 7 9 2.1195177333609485 0.0340467367050727 3.5509708737864076 9.264563106796116 0.3528590781344482 0.4868013249239434 1.8459675362212444 0.9401541669683848 0.9887999500170416 0.3159648114925705 0.0229393586787355 1.0 1.0 0.0557098434243155 0.0007388687073799 +Rac2 gtpase cycle 16 32 2.1106097765876943 0.0348058666466377 8.905339805825243 34.74757281553398 0.8419178475366841 0.4471774138928159 4.131135699306596 3.707034631516275 0.9898490308362274 0.3561406142763811 0.0392931721409943 1.0 0.1827953867238 0.1316996895499912 0.042276670816049 +Transport of inorganic cations anions and amino acids oligopeptides 7 10 2.102878221820091 0.0354764160140543 3.45873786407767 9.99514563106796 1.347451847228265 0.1988162564497566 2.1544143797408783 1.7967002462592632 1.0339867286779445 0.2465647399589519 0.2480080515112862 1.0 0.0666692325567911 0.0893115916137597 0.3610395035532395 +Activation of ampk downstream of nmdars 4 7 2.096555550312549 0.0360329375835704 3.354368932038835 6.451456310679611 0.5566970459139938 0.4440483464816752 1.771033196282823 1.4598419968812493 1.088746190595968 0.3283169353723064 0.00821576936754 1.0 1.0 1.0 0.017002584405276 +Sphingolipid de novo biosynthesis 3 9 2.07907838772577 0.0376101461934987 4.08252427184466 10.614077669902912 1.3205451179619188 0.2079933246203462 1.939118365602947 1.3614298144224892 1.289169434780902 0.261809046515659 0.1033774389046965 0.1280604643503683 0.2445730022705269 0.154226710893935 0.0498364179528963 +Transport of connexons to the plasma membrane 4 5 2.078804572814156 0.0376353164296565 2.7063106796116503 4.587378640776699 0.4995785603281155 0.4095483585324659 1.3523295185638555 0.9949561742458796 1.150433862709782 0.3070287716914409 0.0017074381782845 1.0 1.0 1.0 0.003721367796782 +Gap junction assembly 4 5 2.078804572814156 0.0376353164296565 2.7184466019417477 4.604368932038835 0.499967666973865 0.4121155936503509 1.37358913126072 1.0102774490620512 1.1493312724073153 0.3091304616480874 0.0022568934045067 1.0 1.0 1.0 0.0048822579474643 +Gpcr ligand binding 3 6 2.0760152436356747 0.0378925411669397 3.4611650485436893 9.330097087378642 1.051447004644797 0.2131328881138611 1.5951828582954857 1.3192992367203638 1.3003237502897853 0.2397874119507845 0.2693758032646929 1.0 0.3593428278464597 0.3051232152156647 0.3878167330330442 +O linked glycosylation 3 5 2.059355831534308 0.0394601636494247 1.766990291262136 4.330097087378641 0.8603336668848929 0.3169450005244383 1.1529100664253755 1.1773621125091884 1.0771631098821022 0.279831511700265 0.0468677316875792 1.0 0.2872333566147377 0.051542815486873 0.087821349317486 +Complex i biogenesis 10 30 2.056835366949993 0.0397020648252537 9.1747572815534 28.546116504854368 0.5440760559261008 0.4236381582634617 4.289696810672699 3.852285850983641 1.2631239118061712 0.3404380044043241 0.0014241522214034 1.0 0.4186050092003007 0.0021963027820238 0.0013733005063119 +Ire1alpha activates chaperones 8 26 2.0497916809477976 0.0403847637667191 6.050970873786408 24.223300970873787 0.9379365742980283 0.4047880585679882 2.6930013625985207 2.1985522104416564 1.0262193137091864 0.3353529084578252 0.0070114738153001 0.0181053013145446 0.0085749794431607 0.0039562767661884 0.0048940429574069 +Carboxyterminal post translational modifications of tubulin 4 6 2.0446754339115607 0.0408868671076994 3.2111650485436893 5.764563106796117 0.4532219515804401 0.4130550911105556 1.6044754161745491 1.1192952677926271 1.149295682796638 0.3146953714506392 0.0153533699661252 1.0 1.0 1.0 0.0308662830144804 +Transport of bile salts and organic acids metal ions and amine compounds 2 5 2.0083465389792448 0.0446064796639718 1.8349514563106797 3.995145631067961 1.0286208624357371 0.2748571167414633 1.258733277411433 1.3329199016551914 1.161382969627279 0.2758406238802445 0.1290458946587116 1.0 1.0 0.1800390494619342 0.2015708610705285 +Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 6 18 1.9753485869437823 0.0482286029963059 5.206310679611651 19.733009708737864 0.0173546219692671 0.4747351478662189 2.6010936797167927 3.197629229480199 1.0505158678674285 0.2959489394818763 0.0079740866190119 1.0 0.4353012614103685 0.0136344588869589 0.0234193598976723 +Rhog gtpase cycle 20 34 1.9722464381907052 0.0485814807869053 9.8373786407767 35.66504854368932 0.6614029400837433 0.4973720188279035 4.308521802053122 2.993429981792782 0.9950331841901028 0.3588671909523165 0.0593671241905209 1.0 0.497470817800254 0.244978619195686 0.1296779765755683 diff --git a/msigdb_reactome/metrics.json b/msigdb_reactome/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..17d6b3dce97e23700f8c344829ab6ec5355b44f0 --- /dev/null +++ b/msigdb_reactome/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3120, + "annotations_size": 1384, + "title": "Average number of proteins per term", + "value": 19.272398843930635 +} \ No newline at end of file diff --git a/msigdb_reactome/paths.json b/msigdb_reactome/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..2dffdc129bdf25e5079d67e222ad5408e6ba7d27 --- /dev/null +++ b/msigdb_reactome/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_reactome/fragment/C390/C390_val_log2fc"} \ No newline at end of file diff --git a/msigdb_reactome/result.tsv b/msigdb_reactome/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..d87a75363a46747dcd1b6ec7dad1bdbccf25d3b2 --- /dev/null +++ b/msigdb_reactome/result.tsv @@ -0,0 +1,352 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 0.6300470169535368 4.3122708956017854 1.615862835557813e-05 0.0221155080647907 0.0037272569406869 66 Q16134,Q9P0J0,Q9UDW1,Q9Y6N1,O75880,O14949,O75964,Q9BQ95,P13073,P24539,P14927,O95169,Q86Y39,P09669,P21912,O96000,P00846,P20674,P06576,P22695,Q9Y6M9,Q9NX14,O43819,P56385,P00403,Q8IUX1,Q96I36,Q9NPL8,O95168 29 +Protein localization 0.6188622327260143 4.162326583130863 3.150213670255475e-05 0.0426628435089073 0.0062284224566195 70 Q13011,Q8N4H5,O75381,Q9NS69,Q3ZCQ8,O43808,P21796,O43615,O60830,P50402,Q13190,O95169,O75746,P51648,P40855,Q96B49,Q9UJS0,Q10713,Q13505,Q9NX63,O14925,Q9Y512,Q9NR77,P12235,Q9BY49,P06576,O43765,Q9Y5J9,Q15388,O43681,O75431,Q9Y276,P09601,P46379,O96008,O00116,Q5JRX3,Q15067 38 +Mitochondrial protein import 0.7255814252910173 3.9713213474007736 7.147509037341848e-05 0.0941894134891536 0.0098921525076812 34 Q8N4H5,Q9NS69,Q3ZCQ8,P21796,O43615,O60830,O95169,O75746,Q13505,Q9UJS0,Q96B49,Q10713,O14925,Q9NX63,Q9Y512,P12235,P06576,Q9Y5J9,Q15388,O75431,Q9Y276,O96008,Q5JRX3 23 +Respiratory electron transport 0.6125396179434105 3.768773204397673 0.0001640518599443 0.2031321314970004 0.0206407067420945 56 Q16134,Q9P0J0,Q9UDW1,Q9Y6N1,O75880,O14949,Q9BQ95,P13073,O95169,P14927,Q86Y39,P09669,P21912,O96000,P20674,P22695,Q9Y6M9,Q9NX14,O43819,P00403,Q8IUX1,Q96I36,Q9NPL8,O95168 24 +Cristae formation 0.7678871971483633 3.528268326902923 0.0004182879143885 0.4395591556603898 0.0413507481081284 20 Q6UXV4,Q5XKP0,Q9BUR5,P24539,O75431,P06576,Q16891,P56385,Q13505,Q9NX63,P00846,O75964,Q9Y512 13 +Sphingolipid metabolism 0.7313475103436866 3.4804536434030298 0.0005005654386662 0.499904408835119 0.0432989104446331 24 P06280,P17900,Q13510,O95470,P51648,P04062,P16278,Q9NZJ7,Q9NZD2,P10619,P06865 11 +Glycosaminoglycan metabolism 0.8048006445284162 3.2282338854523194 0.0012455708952676 0.821817079412689 0.0715859458077633 15 O43505,Q7LGA3,Q8TB61,P16278,P15586,P54802,Q8NCH0,Q96L58,P06865,Q11206 10 +Slc mediated transmembrane transport 0.6894224849250381 3.2062389419163515 0.0013448226813597 0.8447140820583745 0.0715859458077633 24 P12236,Q9H936,P12235,P08195,Q70HW3,Q8TB61,P30825,Q15043,Q15758,P35613,Q8TAD4,Q9UBX3,P55011,P05141,Q9Y6M7,Q9NY64 16 +Mitochondrial biogenesis 0.6109004079901579 3.1364628156041405 0.0017099911944147 0.9063933245490424 0.0816078556231029 35 Q6UXV4,Q5XKP0,Q9BUR5,P24539,O75431,Q16891,P56385,Q13505,Q9NX63,P00846,O75964,Q9Y512 12 +Glycosphingolipid metabolism 0.7719797077512586 3.0481444846499692 0.0023025918797343 0.9588471353087954 0.0989295035409175 15 P06280,P17900,Q13510,P16278,Q9NZJ7,Q9NZD2,P10619,P06865 8 +Diseases of glycosylation 0.7233831066265758 3.040881277792431 0.0023588682202675 0.9619376681086232 0.0989295035409175 18 O43505,Q9BT22,Q9H6U8,P16278,Q96L58,Q9BV10,P10619,P06865,Q8NCH0 9 +Mitochondrial calcium ion transport 0.7359847481168112 3.0194948215783364 0.0025319662142497 0.9700637468578964 0.1030659188388734 17 Q9BPX6,Q9Y4W6,P35232,Q8IYU8,P45880,Q9H300,Q9UJZ1,Q99623,Q9Y277,Q10713,Q96TA2,P21796,O95202,Q8NE86 14 +Glycerophospholipid biosynthesis 0.6082496289826473 3.0038066069580855 0.0026662474586311 0.9751529087658798 0.1054310423641594 31 Q96N66,Q8NF37,P35790,Q9UG56,Q8IV08,Q53H12,Q9NQZ5,Q9NPH0,Q9BVG9,Q8NCC3,Q8N2A8 11 +Phospholipid metabolism 0.5611490120557296 2.9941592495403317 0.0027520226362358 0.9779413378928172 0.1057999813486231 47 Q9UG56,Q9NPH0,Q9NTJ5,Q8N2A8,Q86UL3,Q8WWI5,Q96N66,Q8NF37,Q8IY17,Q53H12,Q9BVG9,P61106,Q10713,Q9NUQ2,O95674,P35790,O00459,Q9NZC3,P43304,O75131,Q8TBX8,Q8IV08,Q96PE3,Q9NQZ5,Q8NCC3 25 +Ion channel transport 0.6172127726824023 2.899729521642601 0.0037348479263294 0.9943647084944937 0.1360270928957901 28 P16615,Q9Y487,Q9NW15,P98194,P20020,P05023,Q04656,Q9HD20,P35670,P51790,Q93050,Q15904 12 +The citric acid tca cycle and respiratory electron transport 0.5132522651426409 2.787835497150958 0.0053061480216023 0.9993658730973732 0.1791148502901864 98 Q16134,Q9H9P8,Q9P0J0,P35613,Q9UDW1,Q9Y6N1,O75880,O14949,P21796,O75964,Q9BQ95,P13073,P24539,O95169,P14927,Q86Y39,P09669,P21912,O96000,P00846,P20674,P06576,P22695,Q9Y6M9,Q9NX14,O43819,P56385,P00403,Q8IUX1,P09622,Q13423,Q96I36,Q9NPL8,O95168 34 +Metabolism of porphyrins 0.8075522315051523 2.7011078470624197 0.0069108925050072 0.9999321274253368 0.2224343076030226 10 P30519,P09601,P22830 3 +Selective autophagy 0.555289039639447 2.6475409693544254 0.0081079534686949 0.999987213828536 0.2446497267884948 32 Q15388,Q13885,Q8N4H5,Q9BVA1,P08670,Q9NS69,O95140,Q96B49,Q13099,O96008,P21796,Q9BUF5,P68371 13 +Pre notch processing in golgi 0.9355704628618948 2.5773762748090885 0.0099553514194754 0.9999990312394976 0.247304481121338 5 Q15363,P16615,Q9UBV2 3 +Rnd2 gtpase cycle 0.6447528418293866 2.552800822996888 0.0106860585577048 0.9999996513137444 0.247304481121338 18 Q96RU3,P38159,Q07065,P51648,O00459,Q9Y2U8,Q8TAA9,P02786 8 +Pink1 prkn mediated mitophagy 0.7977651674295487 2.537468362102483 0.0111657460053888 0.9999998217920012 0.247304481121338 9 Q15388,Q8N4H5,Q9NS69,O95140,Q96B49,P21796 6 +Processing of smdt1 0.7203276341740231 2.4588655517510247 0.0139376802944106 0.9999999963386684 0.247304481121338 12 Q9BPX6,Q8NE86,Q9Y4W6,P35232,Q9H300,Q96TA2,Q99623,Q10713,Q9UJZ1,Q8IYU8 10 +Mitophagy 0.7099298073160252 2.402234720135214 0.0162952488479035 0.9999999998666969 0.2675046552729825 12 Q15388,Q8N4H5,Q9NS69,O95140,Q96B49,P21796 6 +Keratan sulfate keratin metabolism 0.8573690536458085 2.387588866077298 0.0169593020684579 0.9999999999476455 0.2695423596312864 6 O43505,Q11206,P16278,P15586 4 +Heparan sulfate heparin hs gag metabolism 0.8879614767255225 2.3778138686055836 0.0174156143905361 0.999999999972465 0.270822587825866 5 Q7LGA3,Q96L58,P16278,P54802 4 +Ion transport by p type atpases 0.6846431035645196 2.3500517415164506 0.0187708015704481 0.9999999999959232 0.2812496424629385 13 P16615,P98194,P20020,P05023,Q04656,Q9HD20,P35670 7 +Formation of atp by chemiosmotic coupling 0.7319516803930772 2.319453866142765 0.0203704398261763 0.9999999999995738 0.2812496424629385 10 P56385,P24539,P00846,O75964 4 +Diseases associated with n glycosylation of proteins 0.8592235164643471 2.2550939701477604 0.0241274310532864 0.999999999999998 0.2955076511305167 5 Q9BV10,Q9BT22 2 +Transport of small molecules 0.512122001230216 2.235513744218952 0.0253836403279124 0.9999999999999996 0.3054865931637458 150 P28074,P49721,Q9Y487,Q9NW15,Q9H936,O75027,Q8N4V1,P20020,O15118,Q9H300,Q04656,Q9UBV2,P35613,Q99623,Q9Y277,Q9HD20,Q96TA2,P21796,O95202,Q8TDW0,P05026,P16615,P98194,O00231,Q9UL46,P08195,P02792,P30519,P35232,Q70HW3,P45880,O75477,P23634,Q8TAD4,P40855,Q10713,Q9NY64,Q15904,Q9H0U3,P08183,P12235,Q9Y4W6,Q8TB61,P05023,P30825,Q15043,O94905,Q9UBX3,P35611,P35670,Q93050,P05141,P61289,Q9BU23,Q9BPX6,Q8NE86,P12236,Q8WTV0,P36543,P38571,Q15758,P28072,Q9UJZ1,P09601,P54709,Q9BUN8,Q9Y6M7,P51790,Q4KMQ2,P02786,Q8WWC4,Q13546,Q8IYU8 73 +Class i peroxisomal membrane protein import 0.7517344649675564 2.209272427463614 0.0271556978067528 1.0 0.3072609695027348 8 Q9NR77,O75381,P51648,P40855,O43808 5 +Cholesterol biosynthesis 0.5908925359661251 2.201137630587459 0.0277262820013051 1.0 0.3072609695027348 18 Q14534,Q16850,Q15800,O95749,Q15392,Q9BWD1,P37268,O75845 8 +Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.614466338617559 2.1952804690345338 0.0281434850373725 1.0 0.3072609695027348 16 Q13217,Q07065,Q02818,Q9BTY2,O43493,O76024,O43852 7 +Pre notch expression and processing 0.6720216038342961 2.192435007447453 0.0283481111809476 1.0 0.3072609695027348 12 Q15363,P16615,Q9UBV2 3 +Heme degradation 0.9168456321208238 2.173695721276686 0.0297279942150483 1.0 0.3093499548393001 4 P30519 1 +Organelle biogenesis and maintenance 0.4544500861176385 2.1389009466413293 0.0324436913753753 1.0 0.3326079175075522 98 Q13561,O95684,Q5XKP0,O94927,Q9H6D7,O75964,Q9NVH1,P24539,Q9BUR5,P41208,Q13505,Q13099,Q10713,P04350,Q9NX63,P00846,Q9Y512,Q6UXV4,P07437,P06576,Q16891,O75935,O43924,P56385,Q13885,Q9BVA1,O75431,Q96CS2,A6NIH7,Q9BUF5,P68371 31 +Depolymerisation of the nuclear lamina 0.7138520861738664 2.1195177333609485 0.0340467367050727 1.0 0.3426607698681319 9 P20700,P06493,Q9Y2U8,P02545,P42167,Q8NC56,P50402 7 +Rac2 gtpase cycle 0.491160380943441 2.1106097765876943 0.0348058666466377 1.0 0.3428740221594609 32 Q14739,Q86XL3,O00459,Q9H0H5,P02786,P05556,O75962,Q9UH62,Q9Y2U8,P42167,Q13505,Q8TAA9,Q14185,P49257,P50402,Q9Y512 16 +Transport of inorganic cations anions and amino acids oligopeptides 0.6905783838069047 2.102878221820091 0.0354764160140543 1.0 0.3457701391792342 10 Q9H936,P08195,Q70HW3,P30825,Q15758,Q9UBX3,Q9Y6M7 7 +Activation of ampk downstream of nmdars 0.7659113228289438 2.096555550312549 0.0360329375835704 1.0 0.3487383609486814 7 Q9BUF5,Q13885,Q9BVA1,P68371 4 +Sphingolipid de novo biosynthesis 0.7059512377205757 2.07907838772577 0.0376101461934987 1.0 0.3495790465680851 9 O15269,O95470,P51648 3 +Transport of connexons to the plasma membrane 0.8186195826645275 2.078804572814156 0.0376353164296565 1.0 0.3495790465680851 5 Q9BUF5,Q13885,Q9BVA1,P68371 4 +Gap junction assembly 0.8186195826645275 2.078804572814156 0.0376353164296565 1.0 0.3495790465680851 5 Q9BUF5,Q13885,Q9BVA1,P68371 4 +Gpcr ligand binding 0.7875802485860864 2.0760152436356747 0.0378925411669397 1.0 0.3496218465002973 6 P42892,Q9Y3E5,Q9NZJ7 3 +O linked glycosylation 0.8141869396995691 2.0593558315343077 0.0394601636494247 1.0 0.3530650648464147 5 O43505,Q10472,Q11206 3 +Complex i biogenesis 0.4968503874287104 2.0568353669499935 0.0397020648252537 1.0 0.3530650648464147 30 Q9BQ95,O95169,Q86Y39,Q9P0J0,Q9Y6M9,O96000,Q9NPL8,Q9NX14,O95168,Q8IUX1 10 +Mucopolysaccharidoses 0.8876765083440199 2.0542629666154086 0.039950247005047 1.0 0.3530650648464147 4 P16278,P15586,P54802 3 +Ire1alpha activates chaperones 0.5173700117080215 2.0497916809477976 0.0403847637667191 1.0 0.3536714004815998 26 O14773,Q13217,Q9NWM8,P43307,Q9Y5M8,O76024,P02545,O95070 8 +Carboxyterminal post translational modifications of tubulin 0.780695561796567 2.0446754339115607 0.0408868671076994 1.0 0.3536714004815998 6 Q9BUF5,Q13885,Q9BVA1,P68371 4 +Transport of bile salts and organic acids metal ions and amine compounds 0.8026037457318201 2.0083465389792448 0.0446064796639718 1.0 0.3741537445753755 5 P35613,Q8TAD4 2 +Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 0.5574515674729433 1.9753485869437823 0.0482286029963059 1.0 0.3931974819244272 18 Q9BT22,Q86YN1,P16278,Q9BV10,P10619,Q11206 6 +Rhog gtpase cycle 0.4731452703615689 1.9722464381907057 0.0485814807869053 1.0 0.3931974819244272 34 P42166,Q86XL3,P42167,O95202,P50402,Q13190,Q86UP2,O95292,Q9Y2U8,Q6IAA8,Q14185,P49257,P51149,Q14739,O96013,P05556,O75962,Q8TAA9,Q96JJ3,P02786 20 +Autophagy 0.4453344250063499 1.9539690160729524 0.0507048815332324 1.0 0.4009789948196309 49 Q15388,Q13885,Q8N4H5,Q9BVA1,P13473,P08670,Q9Y3E7,Q9NS69,P04350,O95140,Q96B49,Q13099,O96008,P21796,Q9BUF5,Q9UQN3,P68371 17 +O linked glycosylation of mucins 0.861526047923482 1.9460187198742451 0.051652490988256 1.0 0.4009789948196309 4 O43505,Q10472 2 +Assembly and cell surface presentation of nmda receptors 0.6282431922251045 1.943558293878806 0.0519487392911197 1.0 0.4009789948196309 12 Q13885,Q9BVA1,Q9BUF5,Q14168,P07196,P68371 6 +Sialic acid metabolism 0.7841596601312183 1.9265734418776084 0.054032811072584 1.0 0.4009789948196309 5 P10619,P16278 2 +Maturation of sars cov 2 spike protein 0.6248651727628715 1.924061237517401 0.0543469080576193 1.0 0.4009789948196309 12 Q9H0U3,P27824,P04843,P46977,Q11206 5 +Rnd1 gtpase cycle 0.5819352545366677 1.9196507824706324 0.0549020249548573 1.0 0.4009789948196309 15 O43396,P38159,P51648,O00459,Q15058,O75976,Q9Y2U8,Q8TAA9,P02786 9 +Immunoregulatory interactions between a lymphoid and a non lymphoid cell 0.7532108508486031 1.9184995874850443 0.0550476943755273 1.0 0.4009789948196309 6 P10321,P04439,P78310,P05556 4 +Synthesis of pa 0.6545250602653305 1.909635757538489 0.0561801277937319 1.0 0.4070853239085078 10 Q8NF37,Q9NUQ2,Q9NPH0,P43304,Q8N2A8 5 +Phase i functionalization of compounds 0.5937355784801586 1.9024552623303832 0.057111662260801 1.0 0.4113521740390249 14 P07099,O43169,P16435,Q16850 4 +Diseases of carbohydrate metabolism 0.6708128728947509 1.8969628157821208 0.0578328458833956 1.0 0.4113521740390249 9 P08236,P16278,P15586,P54802 4 +Class a 1 rhodopsin like receptors 0.7771670551106219 1.8953974802612776 0.0580397622748751 1.0 0.4113521740390249 5 P42892,Q9NZJ7 2 +Peptide ligand binding receptors 0.7771670551106219 1.8953974802612776 0.0580397622748751 1.0 0.4113521740390249 5 P42892,Q9NZJ7 2 +Rab geranylgeranylation 0.5143151776035186 1.8915400015071715 0.0585522964491964 1.0 0.4113521740390249 22 Q9H0U4,Q9BZG1,P62820,P61026,P61019,P61106,Q15907,Q9NP72,Q969Q5,P20338,Q15286,P61020 12 +Copi dependent golgi to er retrograde traffic 0.4434905820458233 1.8710982185645717 0.0613314684772228 1.0 0.4244137618623818 46 Q9H0U4,Q13885,Q9BVA1,Q15363,Q9BVK6,Q8N6T3,Q9P2W9,Q9NSK0,P49755,P68371,Q12981,P04350,Q9BUF5,Q9Y3B3,O15260,P24390 16 +Basigin interactions 0.7342572219538863 1.8305161773051983 0.0671727899903045 1.0 0.4406025656236088 6 P05026,P35613,P05556,P08195 4 +Cell surface interactions at the vascular wall 0.5542679053587143 1.8067336733225576 0.0708038146989853 1.0 0.4600585894056136 16 Q92896,P05026,P08195,Q08722,O00459,P05556,P35613,P62993,P78310 9 +Nuclear envelope ne reassembly 0.4245713196384428 1.7886350714124193 0.0736736058185798 1.0 0.4720568076523819 51 Q8NFH4,Q86XL3,P42167,P50402,Q9Y3E7,Q7Z3B4,Q9Y2U8,P02545,Q8NC56,P04350,Q9UQN3,Q8IXJ6,Q8NFH5,Q9BTX1,Q13885,P20700,Q9BVA1,Q9BUF5,P68371 19 +Rhod gtpase cycle 0.4748465092366865 1.7848111745119637 0.074291950189429 1.0 0.4738251569685242 28 P20700,Q14739,Q5JTV8,O00459,Q9H0H5,Q9Y2U8,P42167,Q8TAA9,Q9Y6M7,P49257,P50402,Q8NHP6 12 +Ras processing 0.7226216102400566 1.7761216023791797 0.0757128763658079 1.0 0.4784777209601742 6 O43924 1 +Sealing of the nuclear envelope ne by escrt iii 0.5984108978455362 1.7699449424840403 0.0767363130044993 1.0 0.4792585411189592 12 Q13885,Q9BVA1,Q9Y3E7,Q8NC56,Q9BUF5,Q9UQN3,P68371 7 +Heme biosynthesis 0.7183769683161988 1.7562080106236886 0.0790528973962758 1.0 0.4840507808781656 6 P22830 1 +Activation of nmda receptors and postsynaptic events 0.4845803336552416 1.754392137041507 0.0793633377241302 1.0 0.4840507808781656 25 Q13885,Q9BVA1,Q9BUF5,Q14168,P07196,P52292,P68371 7 +Iron uptake and transport 0.5251322438559293 1.751697888400462 0.0798257701838141 1.0 0.4845564295368364 18 Q93050,P30519,Q9Y487,P09601 4 +Keratan sulfate degradation 0.8124969388125619 1.7402779505883927 0.0818102238194771 1.0 0.4847412667837664 4 P16278,P15586 2 +Translation of sars cov 1 structural proteins 0.6578646750079056 1.7385920708860585 0.0821065422319708 1.0 0.4847412667837664 8 Q10472,Q11206 2 +Chondroitin sulfate dermatan sulfate metabolism 0.8118965835177514 1.7377376535046218 0.0822570507944608 1.0 0.4847412667837664 4 Q8NCH0,P06865 2 +Diseases associated with glycosaminoglycan metabolism 0.8118965835177514 1.7377376535046218 0.0822570507944608 1.0 0.4847412667837664 4 Q8NCH0,P06865 2 +Miscellaneous transport and binding events 0.7143856515284307 1.7374490131474742 0.0823079463108273 1.0 0.4847412667837664 6 Q9H0U3,P35611,Q8N4V1,Q8TDW0 4 +Insulin receptor recycling 0.63738989832789 1.7203767681713162 0.0853639771288083 1.0 0.4957551269919897 9 Q93050,Q9Y487 2 +Initiation of nuclear envelope ne reformation 0.5309807427725926 1.7191767853243198 0.0855821865447767 1.0 0.4957551269919897 17 P20700,Q14739,P06493,Q8IXJ6,Q86XL3,Q9Y2U8,P02545,P42167,Q8NC56,P50402 10 +Recruitment of numa to mitotic centrosomes 0.4398975719911202 1.700722263506274 0.088995152467507 1.0 0.5073437140614455 37 Q13561,O95684,Q13885,Q9BVA1,P07437,Q96CS2,P41208,O94927,O75935,P04350,Q9BUF5,Q9H6D7,P68371 13 +Intra golgi traffic 0.5356156276315179 1.6829919937415043 0.0923766413298152 1.0 0.5218337616345483 16 O60476,O95721,Q8TBA6,O95249,Q16706,O43752,Q96JB2,Q13190 8 +Copi mediated anterograde transport 0.4034311687709853 1.6655901822282282 0.0957950679295653 1.0 0.5324513012631265 55 Q13561,Q9H0U4,Q13885,Q9BVA1,Q15363,Q9BVK6,Q8N6T3,O95249,O75935,P49755,P68371,P04350,Q9BUF5,Q9Y3B3,Q96JB2,Q13190,P24390 17 +Synthesis of pc 0.6966873754360547 1.653882186651748 0.0981514526809101 1.0 0.5369233617011056 6 Q8NF37,P35790 2 +Reduction of cytosolic ca levels 0.7890853759236083 1.6408752555757282 0.1008233124646724 1.0 0.5427785813098662 4 P20020,P16615 2 +Platelet calcium homeostasis 0.7890853759236083 1.6408752555757282 0.1008233124646724 1.0 0.5427785813098662 4 P20020,P16615 2 +Pi metabolism 0.5173218318805899 1.6254398547065267 0.1040688696029632 1.0 0.5435143982283062 17 Q8IY17,Q96PE3,O00459,Q9NZC3,Q9NTJ5,P61106,Q10713,P20338,Q8TBX8 9 +Egr2 and sox10 mediated initiation of schwann cell myelination 0.6323733695105486 1.6067080766345043 0.1081184210538246 1.0 0.5496716971323139 8 Q9NR77,Q14118,Q16850 3 +Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.5992279301296557 1.605312156381588 0.1084251252291341 1.0 0.5496716971323139 10 O43681,P51648,P46379,P09601,P50402,Q13190 6 +Integrin cell surface interactions 0.7108395232605255 1.5952437118824272 0.1106577473487395 1.0 0.5569102630205657 5 P35613,Q08722 2 +Transport of vitamins nucleosides and related molecules 0.6612961533328202 1.591941512583627 0.1113978468361616 1.0 0.5575351389786992 7 Q8TB61,P12236,P12235 3 +Transferrin endocytosis and recycling 0.5942707858133803 1.5775881613680631 0.1146602538695278 1.0 0.566749254840809 10 Q93050,Q9Y487 2 +Cargo concentration in the er 0.5263495300740384 1.560176852668521 0.118718094088521 1.0 0.575722272550802 15 Q5JRA6,Q15363,Q96PC5,Q9HCU5,P49755,Q12907,O75396,P49257,Q13190 9 +Signaling by retinoic acid 0.5738684897644841 1.5579254370951043 0.1192509244777513 1.0 0.575722272550802 11 Q8NBN7,P50416 2 +Keratan sulfate biosynthesis 0.9393842206542696 1.546899778162004 0.121887414574374 1.0 0.5760271425854563 2 O43505 1 +Maturation of protein 3a 0.9393842206542654 1.5468997781619875 0.121887414574378 1.0 0.5760271425854563 2 Q10472 1 +Unwinding of dna 0.588753013229198 1.5466488527208926 0.1219479427583372 1.0 0.5760271425854563 10 Q14566,Q9Y248 2 +Rnd3 gtpase cycle 0.4950945160302067 1.5392309048396726 0.1237479353175881 1.0 0.5825413009508229 18 P38159,Q07065,O75976,Q9Y2U8,Q8TAA9 5 +Endosomal vacuolar pathway 0.7644415917843208 1.5355537099764016 0.1246478746361567 1.0 0.5832457783740703 4 P10321,Q9UIQ6,P04439 3 +Metabolism of steroid hormones 0.671760876822745 1.5351767139499986 0.124740426588674 1.0 0.5832457783740703 6 O95772,Q53GQ0 2 +Alpha oxidation of phytanate 0.7628116390895973 1.5285658215973383 0.1263721144131007 1.0 0.5869094172742664 4 Q9BY49,P51648 2 +Golgi to er retrograde transport 0.3690674499300895 1.4779771405121005 0.1394138969436951 1.0 0.6159363297051685 70 Q10472,Q9H0U4,Q13885,Q9BVA1,Q15363,Q9P2W9,O75935,P49755,Q8TD16,P68371,Q12981,Q9BUF5,Q9Y3B3,O15260,P24390 15 +Intraflagellar transport 0.537998750918372 1.4775030587948357 0.1395408389658183 1.0 0.6159363297051685 13 Q13885,Q9BVA1,Q13099,Q9BUF5,P68371 5 +Synaptic adhesion like molecules 0.6363747618606408 1.4680578583740775 0.1420885073300037 1.0 0.6171435094871598 7 P41440,O75955,O95197,P10586 4 +Synthesis of pe 0.9156510583707498 1.4483911293424525 0.1475076942479387 1.0 0.6281558425819914 2 P35790 1 +Vitamin d calciferol metabolism 0.9127645926876202 1.4364140112585373 0.1508845685585438 1.0 0.6352008756207114 2 P38435 1 +Tp53 regulates metabolic genes 0.4111136712949834 1.4201345873555795 0.1555685026144473 1.0 0.6352008756207114 36 P13073,P20674,Q9Y6N1,O75880,Q96I36,O43819,P00403 7 +Synthesis of substrates in n glycan biosythesis 0.5156147248826194 1.4095975394745135 0.1586585539680816 1.0 0.6352008756207114 14 P10619,P16278,Q86YN1 3 +Synthesis of very long chain fatty acyl coas 0.5945858507691959 1.4084182187383207 0.1590072675863019 1.0 0.6352008756207114 8 Q9P035,Q53GQ0 2 +N glycan trimming in the er and calnexin calreticulin cycle 0.5030462358397318 1.405822942591327 0.1597767075751861 1.0 0.6352008756207114 15 Q9UBV2,P27824 2 +Hs gag degradation 0.8873917228103863 1.395939791544318 0.1627326267351525 1.0 0.6352008756207114 3 P16278,P54802 2 +Signaling by insulin receptor 0.500303739086399 1.3875324342533149 0.1652794680549794 1.0 0.6352008756207114 15 Q9Y487,P27361,P36543,O00459,Q93050,P31751,Q15904 7 +Post chaperonin tubulin folding pathway 0.5591032430599672 1.3790521488273983 0.1678786758662858 1.0 0.6352008756207114 10 Q9BUF5,Q13885,Q9BVA1,P68371 4 +Intra golgi and retrograde golgi to er traffic 0.3859719992342129 1.3787428053578668 0.1679740666279865 1.0 0.6352008756207114 94 Q13561,Q15363,Q9P2W9,Q9NSK0,Q8TBA6,Q16706,Q13190,O15260,Q10472,O43752,P04350,Q96JB2,P24390,P83436,Q10471,Q9H0U4,O60476,Q8N6T3,P11717,O95721,O60499,O95249,O75935,P49755,P20645,Q12981,Q13885,Q9BVA1,Q9BVK6,Q9BUF5,O43493,Q8TD16,O75396,Q9Y3B3,P68371 35 +Ros and rns production in phagocytes 0.5859236800985046 1.3625536291706768 0.1730232314974584 1.0 0.6352008756207114 8 Q93050 1 +Cytoprotection by hmox1 0.355272121864739 1.360704557864085 0.1736070736563686 1.0 0.6352008756207114 66 P28074,P49721,P20674,P13073,P30519,P09601,O43819,Q8TCT9,P00403 9 +Metal ion slc transporters 0.8938422065426619 1.3579616156657852 0.1744758642402233 1.0 0.6352008756207114 2 Q8TAD4 1 +Zinc transporters 0.8938422065426619 1.3579616156657852 0.1744758642402233 1.0 0.6352008756207114 2 Q8TAD4 1 +Response to elevated platelet cytosolic ca2 0.4201725556369495 1.3545319237022513 0.1755667356760302 1.0 0.6352008756207114 29 O94919,Q6UXV4,P13473,Q8NBX0,Q08380,Q92520,Q9NZJ7,Q9Y6I9 8 +Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0.6582108561936053 1.352310065455454 0.1762761457883592 1.0 0.6353286087788782 5 P12236,P12235 2 +Recruitment of mitotic centrosome proteins and complexes 0.4012889456922405 1.3074841750392523 0.1910483259959079 1.0 0.6544823841047935 33 Q13561,O95684,P07437,Q96CS2,P41208,O94927,O75935,P04350,Q9H6D7,P68371 10 +Diseases associated with o glycosylation of proteins 0.8806927517639646 1.3035487523016152 0.1923874836362558 1.0 0.6574426601298222 2 O43505 1 +Anchoring of the basal body to the plasma membrane 0.4004806930867484 1.299899255356415 0.1936355003678094 1.0 0.6600776662784439 33 Q13561,O95684,P07437,Q96CS2,P41208,O94927,O75935,P04350,Q9H6D7,P68371 10 +Stimuli sensing channels 0.6023621180909923 1.2971647309592842 0.1945745130613265 1.0 0.6610665014402415 7 Q9NW15,P51790,Q4KMQ2 3 +Apoptotic cleavage of cellular proteins 0.4410068807405224 1.2842010300633246 0.199071624886119 1.0 0.6716957270252532 20 P20700,Q16625,P51572,P35611,P02545,P08670,P49354 7 +Cilium assembly 0.3489866217764326 1.27462191855806 0.2024430956075054 1.0 0.6735126065403545 63 Q13561,O95684,Q13885,Q9BVA1,P07437,Q96CS2,P41208,O94927,O75935,Q13099,Q10713,O43924,P04350,Q9BUF5,A6NIH7,Q9H6D7,P68371 17 +Synthesis of pg 0.8559512351620159 1.2729362877740409 0.2030406511540965 1.0 0.6738807222956106 3 Q8N2A8,Q8IV08 2 +Nuclear envelope breakdown 0.3901743112178321 1.253504804413022 0.2100220517119002 1.0 0.6803426844911018 40 Q9NRG9,Q8NFH4,P20700,Q99567,P06493,Q8NFH5,P42166,Q7Z3B4,Q9Y2U8,P02545,P42167,Q9BTX1,Q8NC56,Q96EE3,Q8N1F7,P50402 16 +Diseases associated with glycosylation precursor biosynthesis 0.5932402770216278 1.2510434528118666 0.2109186244752852 1.0 0.6803426844911018 7 P10619 1 +Metabolism of folate and pterines 0.5493141008813524 1.2413122405013208 0.214490424580811 1.0 0.6824247071720516 9 Q9H2D1,P00374 2 +Calnexin calreticulin cycle 0.5627160048556143 1.239069200961315 0.2153198717443172 1.0 0.6834924369131538 8 Q9UBV2 1 +Rac3 gtpase cycle 0.4022941000776224 1.2319275964844865 0.2179761316616026 1.0 0.6871958228238226 30 Q14739,O00459,Q9H0H5,Q15758,P05556,Q9UQB8,Q9Y2U8,O75962,P42167,Q8TAA9,P02786,P49257,P50402 13 +Synthesis of pips at the golgi membrane 0.6049526707579498 1.2124083718753065 0.2253560978049169 1.0 0.6971592807223713 6 Q10713 1 +Apoptotic factor mediated response 0.6892832322454183 1.2115881936241806 0.2256700561875884 1.0 0.6971592807223713 4 P27361,Q9NR28 2 +Ion homeostasis 0.5050847201574198 1.2080698101011598 0.2270204110748621 1.0 0.6997689285692856 12 P05026,P16615,P20020,P05023,P23634 5 +Amino acid transport across the plasma membrane 0.6865118873821245 1.1996155023877733 0.2302887030437623 1.0 0.7051317810012547 4 P30825,P08195 2 +Cell death signalling via nrage nrif and nade 0.5375387465916972 1.1761307451094272 0.2395426337080155 1.0 0.7175909200257435 9 O75962,Q92542 2 +Extracellular matrix organization 0.4064617492686622 1.1687752377455274 0.2424941995316745 1.0 0.7192142391817118 27 O75718,Q32P28,Q08722,Q92542,P55081,P35613,P13674,Q14118 8 +Suppression of apoptosis 0.6790298002023367 1.1673020669774616 0.2430884042332792 1.0 0.7192142391817118 4 P23246,P27361 2 +Peroxisomal lipid metabolism 0.4974798151950015 1.1613163575301535 0.2455132697768842 1.0 0.724499712945006 12 Q9BY49,P51648,O15254,P22307,A8MXV4,O43808,Q15067 7 +Transport to the golgi and subsequent modification 0.3547140465850742 1.1431283844293576 0.2529852908690952 1.0 0.7406875224470587 82 Q13561,Q15363,Q96PC5,Q16706,Q13190,Q5JRA6,Q12907,P04350,P49257,Q96JB2,Q11206,P24390,Q9H0U4,O60476,Q8N6T3,O95249,O75935,P49755,Q13885,Q9BVA1,Q9BVK6,Q9BUF5,P04066,Q14789,O75396,Q9Y3B3,P68371 27 +Unfolded protein response upr 0.3759185042459475 1.1428931321438012 0.2530829643750891 1.0 0.7406875224470587 43 O14773,Q13217,Q92945,Q9NWM8,Q9HCU5,Q96B26,Q8N6T3,P43307,Q9Y5M8,P49840,P35611,P02545,O76024,O95070 14 +Biological oxidations 0.3757792501649861 1.141469077813487 0.2536747728612036 1.0 0.7406875224470587 43 Q9NUJ1,P21964,Q8TB61,P16435,P07099,Q16850,Q9NX62,O43169 8 +Cooperation of prefoldin and tric cct in actin and tubulin folding 0.4396740176286934 1.1373527437088082 0.2553908539131173 1.0 0.7410082637646842 18 O15212,Q13885,Q9BVA1,P04350,Q9BUF5,P68371 6 +Trans golgi network vesicle budding 0.3781925532621503 1.1254225268341185 0.2604100296898486 1.0 0.7492879024755726 39 O60749,P02792,P55327,Q9Y5X3,P11717,P78537,O75976,O43493,Q14789,P15586,Q12846,P20645 12 +Aurka activation by tpx2 0.3811573218140928 1.1174378568039824 0.2638071562713062 1.0 0.7559194705579458 33 Q13561,O95684,P07437,Q96CS2,P41208,O94927,O75935,P04350,Q9H6D7,P68371 10 +Hyaluronan metabolism 0.6063576370751415 1.11076585102779 0.2666691490418627 1.0 0.7594035026212715 5 P08236,P06865 2 +Hyaluronan uptake and degradation 0.6063576370751415 1.11076585102779 0.2666691490418627 1.0 0.7594035026212715 5 P08236,P06865 2 +Cytosolic sulfonation of small molecules 0.6058136345806348 1.1082301597715218 0.2677624287466598 1.0 0.7609511322081666 5 Q9NX62 1 +Role of phospholipids in phagocytosis 0.6037780658798282 1.0987429630381966 0.2718801970615387 1.0 0.7663625577578125 5 Q8IV08 1 +Translation of sars cov 2 structural proteins 0.4336648782407027 1.093213229400915 0.2743001898434409 1.0 0.7672709864329382 18 Q9H0U3,Q10472,P27824,P04843,P46977,Q11206 6 +Cargo recognition for clathrin mediated endocytosis 0.3764257853555977 1.092937270745756 0.2744213426909714 1.0 0.7672709864329382 37 Q14108,Q9BT78,Q92783,Q9UHD9,P11717,O14657,O43493,Q99627,P02786,P20645,Q9NY64 11 +Striated muscle contraction 0.6008023319361174 1.0848770323202812 0.277976121690267 1.0 0.7703630880740423 5 P08670,P67936,P09493 3 +Interleukin 4 and interleukin 13 signaling 0.4764543732923034 1.031679053598091 0.3022224931355048 1.0 0.809856078721879 12 Q07820,P09601 2 +Caspase mediated cleavage of cytoskeletal proteins 0.588968046183449 1.029785149672367 0.3031108733944605 1.0 0.809856078721879 5 P08670,P35611 2 +Rhoa gtpase cycle 0.3630268794605782 1.0218507215011785 0.3068515587819374 1.0 0.8142639150378006 44 P41440,Q96CS3,Q14739,Q8NBN3,O75955,P30519,Q96HY6,O00459,Q9H0H5,P51572,O75962,P42167,Q8TAA9,P02786,Q9NRG9,P49257,Q13190,Q15904 18 +Protein protein interactions at synapses 0.4388765767645124 1.0203163422248636 0.3075784552517637 1.0 0.8142639150378006 16 P41440,Q9Y2J2,Q13136,Q14168,O75955,O95197,P10586 7 +Asparagine n linked glycosylation 0.3811459565362889 1.0149808269873035 0.3101149670405412 1.0 0.8142639150378006 120 Q13561,Q9BT22,Q15363,Q96PC5,P46977,Q9UBV2,Q16706,Q86YN1,Q13190,Q5JRA6,Q12907,P04350,P49257,Q96JB2,P24390,Q11206,Q9H0U3,Q9H0U4,P27824,O60476,Q8N6T3,O95249,O75935,P49755,Q9BV10,P10619,Q13885,Q9BVA1,P04843,Q9BVK6,Q9H6U8,Q9BUF5,P04066,Q14789,Q9BUN8,P16278,O75396,Q9Y3B3,P68371 39 +N glycan antennae elongation in the medial trans golgi 0.7892204042348271 1.013871573883999 0.3106440369508372 1.0 0.8142639150378006 3 P04066,Q11206 2 +The activation of arylsulfatases 0.8088518280949322 1.009869431922685 0.3125578496197221 1.0 0.8161887997616895 2 O43681 1 +Cardiac conduction 0.4626981982507142 1.0023779215263156 0.3161611012985523 1.0 0.8209511523399559 13 P05026,P16615,P20020,P05023,P23634 5 +Cs ds degradation 0.8053239255933463 0.9956984460629288 0.3193966853674606 1.0 0.8216450047371106 2 P06865 1 +Er to golgi anterograde transport 0.3365648628366855 0.9795078856723904 0.3273290942040223 1.0 0.8342973598128305 77 Q13561,Q15363,Q96PC5,Q13190,Q5JRA6,Q12907,P04350,P49257,Q96JB2,P24390,Q9H0U4,Q8N6T3,O95249,O75935,P49755,Q13885,Q9BVA1,Q9BVK6,Q9BUF5,Q14789,O75396,Q9Y3B3,P68371 23 +Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.5012470004234183 0.9746043342808892 0.3297565628313963 1.0 0.838939490732817 9 Q9UJX6,Q9UJX4,P30260,Q16763,Q9UJX3,Q9UJX5 6 +Rhof gtpase cycle 0.4152349880193884 0.9575093176272348 0.3383102457119378 1.0 0.851311600118767 18 P20700,O00459,P42167,Q8TAA9,Q9Y6M7 5 +Gap junction trafficking and regulation 0.4640179827967773 0.9548816723031996 0.3396375391257042 1.0 0.8515819853000116 12 Q9BUF5,Q13885,Q9BVA1,P68371 4 +Pregnenolone biosynthesis 0.6292754669286109 0.953524955308011 0.3403241582571872 1.0 0.8517335172295607 4 O95772 1 +Mitotic prophase 0.3349923844812142 0.9348400299058268 0.3498707466040129 1.0 0.8687380997673421 57 Q8NFH4,P06493,P42166,P61019,P42167,P50402,Q01105,Q8TEM1,Q7Z3B4,Q9Y2U8,P02545,Q8NC56,Q8N1F7,Q9H0U4,Q99567,Q8NFH5,Q9BTX1,Q96EE3,Q9NRG9,P20700,P27361,P16104 22 +Prevention of phagosomal lysosomal fusion 0.6245186136071859 0.9332639350304344 0.350683711190795 1.0 0.8687380997673421 4 P20339,O14964,P51149 3 +Reactions specific to the complex n glycan synthesis pathway 0.7889672867222782 0.9304459692358048 0.3521402268565599 1.0 0.8687380997673421 2 P04066 1 +Neuronal system 0.3392050688486723 0.9190697198512582 0.3580591061691993 1.0 0.8705237422488642 54 O75915,P41440,P04899,Q13885,P21964,Q9BVA1,Q14168,Q9Y2J2,Q9BUF5,Q13136,P04350,P07196,O75955,O95197,P52292,P68371,P10586 17 +Aggrephagy 0.4223828225543738 0.9053156990776524 0.3652981617665642 1.0 0.8807885991026567 16 Q13885,Q9BVA1,Q13099,P08670,Q9BUF5,P68371 6 +Nrif signals cell death from the nucleus 0.7809493264913651 0.8987600545923106 0.3687804812156114 1.0 0.8810353276181192 2 Q92542 1 +Cytochrome p450 arranged by substrate type 0.7589810010839801 0.8986142874350629 0.3688581458398179 1.0 0.8810353276181192 3 Q16850 1 +Plasma lipoprotein clearance 0.4460363697453084 0.8963274737638058 0.3700778899035697 1.0 0.8810353276181192 13 Q8WTV0,O15118 2 +G alpha q signalling events 0.4614375378257078 0.8897101672230113 0.3736215332478316 1.0 0.8824099010494864 11 O75962,Q8NCG7,O00459,P27361 4 +Golgi associated vesicle biogenesis 0.3571244000605368 0.886272760378712 0.3754705638189541 1.0 0.8837606468119602 32 O60749,P02792,P55327,Q9Y5X3,P11717,P78537,O75976,O43493,Q14789 9 +Retrograde transport at the trans golgi network 0.4045597531724406 0.8788374869059962 0.3794893974780107 1.0 0.8901920781518081 18 O60499,O43493,Q96JB2,P20645 4 +Copi independent golgi to er retrograde traffic 0.365220961976871 0.8639385099761147 0.3876216703250619 1.0 0.8959380255889916 29 Q13885,Q10472,Q9BVA1,Q8TD16,O75935,Q9BUF5,P68371 7 +Rhoj gtpase cycle 0.3812447509470961 0.8627941965955699 0.3882506305202073 1.0 0.8959380255889916 23 Q96RU3,P42166,O00459,Q15758,O75962,P42167,Q8TAA9,P02786,Q9Y6M7 9 +Receptor type tyrosine protein phosphatases 0.7690827453495818 0.8522788035421485 0.3940593676884334 1.0 0.8984813259980096 2 P10586 1 +Sars cov 1 infection 0.4295856124101234 0.8472850761886017 0.3968362429295391 1.0 0.9001753700997834 14 Q10472,P27824,Q9UQN3,Q11206 4 +Dap12 interactions 0.5296172966125768 0.8462666447329513 0.3974040109327801 1.0 0.9001753700997834 6 P10321,O00459,P01889 3 +Phosphorylation of the apc c 0.4459355638726555 0.843356655166547 0.3990290058373775 1.0 0.9023793203904096 12 Q9UJX6,Q9UJX4,P30260,P06493,Q16763,P53350,Q9UJX3,Q9UJX5 8 +Attachment of gpi anchor to upar 0.7404555662495942 0.8291080107803146 0.4070432911834574 1.0 0.9131344276590996 3 Q96S52,Q92643 2 +Abc family proteins mediated transport 0.3410502989519204 0.8266199487622605 0.4084525068477165 1.0 0.9131344276590996 47 P28074,P49721,P08183,O75027,O75477,O94905,Q9UBV2,Q9BUN8,O00231 9 +Interleukin receptor shc signaling 0.7588197562540101 0.8125208906153224 0.4164928043780063 1.0 0.9158193894805198 2 O00459 1 +Role of lat2 ntal lab on calcium mobilization 0.7588197562540101 0.8125208906153224 0.4164928043780063 1.0 0.9158193894805198 2 O00459 1 +Rho gtpases activate iqgaps 0.4401482929829465 0.8077607221776889 0.4192283401556849 1.0 0.9158193894805198 12 Q9BUF5,Q13885,Q9BVA1,P68371 4 +Signaling by notch 0.3218251925345205 0.8013799389548584 0.4229117252527061 1.0 0.9158193894805198 58 P28074,P49721,P16615,Q15363,Q92542,Q9UBV2 6 +Golgi cisternae pericentriolar stack reorganization 0.4463206114803482 0.799367792574687 0.4240771800879939 1.0 0.9158193894805198 11 Q9H0U4,P27361,P61019,P06493 4 +Plasma lipoprotein remodeling 0.752084669660039 0.7866748150514461 0.4314722507500237 1.0 0.9158193894805198 2 Q9BU23 1 +Formation of tubulin folding intermediates by cct tric 0.4264951152489772 0.7723408199627338 0.4399125947363975 1.0 0.9158193894805198 13 Q9BUF5,Q13885,Q9BVA1,P68371 4 +Sars cov 2 infection 0.3680061782424184 0.7718007733108746 0.4402324336624865 1.0 0.9158193894805198 24 Q9H0U3,Q10472,P27824,P04843,Q9Y3E7,P46977,Q9UQN3,Q11206 8 +Formation of apoptosome 0.7229630185098194 0.7644661890992032 0.444589478031159 1.0 0.9169438625825812 3 Q9NR28 1 +Cytochrome c mediated apoptotic response 0.7229630185098194 0.7644661890992032 0.444589478031159 1.0 0.9169438625825812 3 Q9NR28 1 +Apc c cdc20 mediated degradation of cyclin b 0.4391940170168587 0.7569496130589172 0.4490800501782677 1.0 0.919418327583909 11 Q9UJX6,Q9UJX4,P30260,P06493,Q16763,Q9UJX3,Q9UJX5 7 +Sars cov infections 0.3118600981055533 0.7529117906231305 0.4515029224330285 1.0 0.9202946165645234 61 Q99720,P46977,Q02790,Q16706,P49354,P05026,Q10472,Q9Y3E7,Q9UQN3,Q11206,Q9H0U3,P27824,P05023,P07437,P05556,P21964,P04843,Q8WXI9,P54709 19 +Aspartate and asparagine metabolism 0.525636724327122 0.7387636343261873 0.46005053761854 1.0 0.926384099811705 5 Q9UJS0 1 +Slc transporter disorders 0.3406982369633519 0.7312056513304922 0.4646535488067345 1.0 0.926552748787263 33 Q9NRG9,Q8NFH4,P57740,Q8TEM1,P08195,Q99567,P37198,Q8NFH5,P35613,Q7Z3B4,P19367,Q9BTX1,Q96EE3,Q8N1F7 14 +Kinesins 0.3833709704055354 0.7231693214431526 0.469575864339379 1.0 0.926552748787263 18 Q13885,Q9BVA1,Q9NSK0,Q9BUF5,P68371 5 +Muscle contraction 0.3538154258024622 0.6908101221745855 0.4896848736512798 1.0 0.9286087186011056 26 P20020,P16615,P05023,P08670 4 +Cellular response to chemical stress 0.3132509281319438 0.6836390720320792 0.4942031058030267 1.0 0.9304163534996543 77 P28074,P13073,P20674,P49721,P30519,Q8TED1,Q04656,P09601,Q9Y6N1,O75880,O43819,Q8TCT9,P00403 13 +Runx2 regulates bone development 0.563178738684545 0.677712710733617 0.4979538656415572 1.0 0.9304163534996543 4 P27361 1 +Beta oxidation of pristanoyl coa 0.6965030478023753 0.6689500410373862 0.5035273473780644 1.0 0.9304163534996543 3 O15254,P22307 2 +Ptk6 regulates proteins involved in rna processing 0.7190506735086569 0.6631967014718837 0.5072045837799477 1.0 0.9305993158983225 2 P23246 1 +Wax and plasmalogen biosynthesis 0.5595806779028295 0.6631800714686827 0.5072152332242761 1.0 0.9305993158983225 4 Q8WVX9,O00116 2 +Platelet homeostasis 0.4342014629773223 0.6627985836844487 0.5074595608491586 1.0 0.9305993158983225 10 P20020,P16615 2 +Elastic fibre formation 0.6940138306293302 0.6601266465642374 0.5091725601427788 1.0 0.9305993158983225 3 P55081 1 +Molecules associated with elastic fibres 0.6940138306293302 0.6601266465642374 0.5091725601427788 1.0 0.9305993158983225 3 P55081 1 +Peptide hormone metabolism 0.4150295827793392 0.65439894721966 0.5128548124994354 1.0 0.9305993158983225 12 Q15005,O75787,Q8TAD4,Q96HE7 4 +Gamma carboxylation hypusine formation and arylsulfatase activation 0.4513082502214569 0.6459076864955806 0.5183391413742489 1.0 0.9305993158983225 8 P38435,O60725,Q8NBJ7,O43681 4 +Metabolism of lipids 0.3992166603148022 0.6207539823768635 0.5347615051818828 1.0 0.9354683669793376 181 Q9H7Z7,Q9UG56,Q9NPH0,Q9NTJ5,O95749,P04062,Q06136,Q15392,O15269,Q8N2A8,P23786,Q12770,P50416,O95772,P06280,Q8NF37,Q96N66,O43772,Q13510,Q14534,P04035,P51648,P50897,Q53H12,Q9BVG9,Q10713,Q9NZD2,P35790,O95674,P17900,Q9P035,Q9BY49,O00459,P09960,Q9NZC3,P30536,Q9NZJ7,Q9NPJ6,Q15165,P37268,P10619,O75845,Q9UMR5,O43681,O95470,Q8IV08,Q9NQZ5,Q16850,Q15800,Q9BWD1,P16278,O00116,Q8NCC3,P38435,P06865,Q15067,Q53GQ0 57 +Metabolism of steroids 0.3229245169159436 0.5969808838060705 0.5505201435476752 1.0 0.94531002316375 43 Q53GQ0,O75845,Q14534,Q16850,Q15800,O95749,P04062,Q15392,P30536,Q9BWD1,P38435,P37268,Q12770,O95772 14 +Insulin receptor signalling cascade 0.4765931654883623 0.5953175420446946 0.5516312322183394 1.0 0.9460441454649092 6 O00459,P27361,P31751 3 +Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol 0.6962796664528514 0.5818921571416146 0.5606393235954286 1.0 0.9499297961773842 2 P22307 1 +Signal attenuation 0.670133091706764 0.5771337462892578 0.5638491092097948 1.0 0.9520756537332888 3 P27361 1 +Signaling by flt3 fusion proteins 0.5358558575896188 0.569155505926446 0.5692506128484824 1.0 0.9520756537332888 4 Q14789 1 +Linoleic acid la metabolism 0.6917896087235376 0.5662895905614628 0.5711969354909556 1.0 0.9520756537332888 2 P33121 1 +Dopamine neurotransmitter release cycle 0.6895445798588808 0.5585452820141089 0.5764720925077695 1.0 0.9532107240510788 2 Q13136 1 +Ncam signaling for neurite out growth 0.4645445714431256 0.5401789227984863 0.5890736467892346 1.0 0.9575815804731104 6 P62993,P27361 2 +Plasma lipoprotein assembly remodeling and clearance 0.3687398883569113 0.5355374924323338 0.5922782390769528 1.0 0.9585734777139778 16 Q8WTV0,O15118 2 +Vitamin c ascorbate metabolism 0.6564003849855624 0.5309250616297734 0.5954707100691856 1.0 0.9585734777139778 3 P00387,P78417 2 +Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components 0.3932835459983673 0.5241603075340385 0.6001670456488046 1.0 0.9585734777139778 12 Q9UJX6,O60566,Q9UJX4,P30260,Q16763,Q9UJX3,Q13257,Q9UJX5 8 +Apc cdc20 mediated degradation of nek2a 0.3932835459983673 0.5241603075340385 0.6001670456488046 1.0 0.9585734777139778 12 Q9UJX6,O60566,Q9UJX4,P30260,Q16763,Q9UJX3,Q13257,Q9UJX5 8 +Regulation of plk1 activity at g2 m transition 0.3171654422186045 0.5141258867963313 0.6071639797066961 1.0 0.9585734777139778 38 Q13561,O95684,P07437,Q96CS2,P41208,O94927,O75935,P04350,Q9H6D7,P68371 10 +Collagen biosynthesis and modifying enzymes 0.4073166046996183 0.5132216686375474 0.6077962701840907 1.0 0.9585734777139778 10 Q32P28,P13674,O75718 3 +Activation of bad and translocation to mitochondria 0.4458721490523661 0.511989242787223 0.6086585382176919 1.0 0.9585734777139778 7 P62258,Q04917,P31946,P61981,P63104,P31751 6 +Regulation of lipid metabolism by pparalpha 0.3397804303673685 0.5061026121694917 0.6127846168910178 1.0 0.9585734777139778 21 P04035,P37268,P23786,Q15067,P50416 5 +Ras activation upon ca2 influx through nmda receptor 0.4568710031797621 0.5055764873203232 0.613153991139701 1.0 0.9585734777139778 6 P07196 1 +Long term potentiation 0.4568710031797621 0.5055764873203232 0.613153991139701 1.0 0.9585734777139778 6 P07196 1 +Unblocking of nmda receptors glutamate binding and activation 0.4568710031797621 0.5055764873203232 0.613153991139701 1.0 0.9585734777139778 6 P07196 1 +Degradation of the extracellular matrix 0.4413740424071203 0.4906015160718188 0.6237083139280624 1.0 0.9591001455118652 7 P35613 1 +Ikk complex recruitment mediated by rip1 0.6438883541867159 0.4899195530356936 0.6241908262190041 1.0 0.9591001455118652 3 Q13546,P61088 2 +Ticam1 rip1 mediated ikk complex recruitment 0.6438883541867159 0.4899195530356936 0.6241908262190041 1.0 0.9591001455118652 3 Q13546,P61088 2 +Potential therapeutics for sars 0.3140958876344735 0.4818225670755323 0.6299319966981218 1.0 0.9591001455118652 37 Q99720,P21964,P05023 3 +Negative regulation of nmda receptor mediated neuronal transmission 0.4376039618736467 0.4727934943851427 0.6363605158988941 1.0 0.9646472661599884 7 P07196 1 +G alpha s signalling events 0.5055118334840533 0.4544971175162645 0.6494710661355427 1.0 0.9715026912597668 4 Q9Y3E5 1 +Peroxisomal protein import 0.3336577131518853 0.4519636259514129 0.651295186659872 1.0 0.9715026912597668 20 Q13011,Q9BY49,Q15067,O00116 4 +Transmission across chemical synapses 0.3075885944831194 0.4405286797900576 0.6595542450840726 1.0 0.9715026912597668 43 P04899,Q13885,P21964,Q9BVA1,Q14168,Q9BUF5,Q13136,P04350,P07196,O75915,P52292,P68371 12 +Rac1 gtpase cycle 0.3076184558280767 0.4354592130307481 0.6632291382796465 1.0 0.9715026912597668 42 Q14739,O00459,Q9H0H5,Q15758,P05556,Q9UQB8,Q9Y2U8,O75962,P42167,Q8TAA9,P02786,Q14185,P50402 13 +Chaperone mediated autophagy 0.4078836163394265 0.4263173910513227 0.6698765871606833 1.0 0.9738541981411614 8 P08670,P13473 2 +Phase ii conjugation of compounds 0.3178765729038074 0.4225935402872089 0.6725918404375579 1.0 0.9743294130404808 28 P21964,Q9NUJ1,Q9NX62 3 +Irak1 recruits ikk complex 0.6436818473380329 0.4097109847852359 0.682017971065322 1.0 0.9743294130404808 2 P61088 1 +Downregulation of erbb2 signaling 0.4462279293740007 0.3992309617960471 0.6897230314678717 1.0 0.9785209787232156 5 Q9UNE7,Q16543,Q93034,P31751 4 +Regulation of localization of foxo transcription factors 0.4455858747993618 0.3966929533469776 0.6915938971585627 1.0 0.9785209787232156 5 P63104,P61981,P31946,P31751 4 +Cargo trafficking to the periciliary membrane 0.3253470553151778 0.3963726099480775 0.6918301690117274 1.0 0.9785209787232156 21 O43924,Q10713 2 +Negative regulation of met activity 0.420678690085006 0.3943389242151137 0.6933308292790434 1.0 0.9791529262471388 7 P62993,Q92783,P18031 3 +Post translational modification synthesis of gpi anchored proteins 0.4264710933119329 0.3733863454121542 0.7088609206631478 1.0 0.9816129941532384 6 Q5H8A4,Q92643 2 +Pyruvate metabolism 0.343519004014538 0.3688553295201764 0.7122355609764841 1.0 0.9816129941532384 16 P35613,P21796 2 +Oncogene induced senescence 0.4382022471910152 0.3678257393325826 0.7130031752511536 1.0 0.9816129941532384 5 Q9HCE1,P11802,P27361,P28482 4 +Rhobtb1 gtpase cycle 0.3211978506498458 0.3653821407427579 0.7148261706874184 1.0 0.9816129941532384 21 P62995,Q9BT78,P07910,P38159,P08670 5 +Platelet aggregation plug formation 0.4323578577671176 0.3454120463832437 0.7297846221424826 1.0 0.9829874651868332 5 P18031,P46108 2 +Integrin signaling 0.4323578577671176 0.3454120463832437 0.7297846221424826 1.0 0.9829874651868332 5 P18031,P46108 2 +Lipophagy 0.4727214377406964 0.339842707239305 0.7339749842342995 1.0 0.9839389092907268 4 P54646,P54619,O60664 3 +Collagen formation 0.3604112007652615 0.3353081956053785 0.7373926120357339 1.0 0.9860399759009236 12 Q32P28,P13674,O75718 3 +Hcmv infection 0.2865783688346403 0.320297772741324 0.7487426113933127 1.0 0.9935376550032068 54 Q13885,Q8NFH4,Q9BVA1,Q99567,Q8NFH5,P61978,Q9HD42,Q9Y3E7,Q9BUF5,P05556,Q7Z3B4,Q9H9H4,Q9BTX1,P04350,Q9NRG9,Q8N1F7,Q9UQN3,P68371 18 +Gastrin creb signalling pathway via pkc and mapk 0.4249386973528182 0.3175486933145321 0.750827297826012 1.0 0.9940661591618792 5 P27361 1 +Cdc42 gtpase cycle 0.3006257662479657 0.3123204147635011 0.7547970267436486 1.0 0.9967930200507724 30 Q86UP2,Q96RU3,Q14739,O96013,P42166,O00459,Q9H0H5,P02786,Q9UQB8,O75962,P42167,Q6IAA8,Q8TAA9 13 +Late endosomal microautophagy 0.358535807334278 0.2985775212974529 0.7652624188940595 1.0 1.0 11 P08670,Q9Y3E7,Q13099,Q9UQN3 4 +Diseases of mitotic cell cycle 0.3524211557911066 0.2914981012172673 0.7706703958661534 1.0 1.0 12 Q9UJX6,Q9UJX4,P30260,Q16763,Q9UJX3,P11802,Q9UJX5 7 +Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand 0.2958451087995487 0.2907631230743279 0.7712324908642478 1.0 1.0 31 Q13885,Q9BVA1,O75935,Q9BUF5,P68371 5 +Signaling by type 1 insulin like growth factor 1 receptor igf1r 0.4173086780091639 0.289623442665373 0.7721043306596358 1.0 1.0 5 O00459,P31751 2 +Tysnd1 cleaves peroxisomal proteins 0.4171391799354897 0.2890118502235224 0.7725723091802714 1.0 1.0 5 O00116 1 +Antigen presentation folding assembly and peptide loading of class i mhc 0.3406490021219288 0.2866131223821254 0.7744085655999264 1.0 1.0 14 P10321,P51572,P27824 3 +Sumoylation of rna binding proteins 0.2925472747592687 0.2831313682825118 0.777076136554693 1.0 1.0 32 Q9NRG9,Q8NFH4,Q8TEM1,P07910,Q99567,Q8NFH5,P61978,Q7Z3B4,Q9BTX1,Q96EE3,Q8N1F7 11 +Cd28 dependent pi3k akt signaling 0.5711447930474381 0.2773791922749183 0.7814889571918036 1.0 1.0 3 O00459 1 +Irs mediated signalling 0.4520313425671499 0.2736441730821359 0.7843580839664417 1.0 1.0 4 O00459,P31751 2 +Signalling to ras 0.569457811998718 0.273064546376666 0.7848035992783506 1.0 1.0 3 P11233,P62993 2 +Synthesis of prostaglandins pg and thromboxanes tx 0.4513819466150775 0.2716531578326471 0.785888721797132 1.0 1.0 4 Q9H7Z7 1 +Disorders of transmembrane transporters 0.2757937593761843 0.2623294319642222 0.7930674729064677 1.0 1.0 73 P28074,P49721,Q8NFH4,P35613,Q9UBV2,O00231,Q9UL46,P08195,O75477,Q7Z3B4,Q8N1F7,Q99567,Q8NFH5,O94905,Q9BTX1,Q96EE3,Q9NRG9,P28072,Q9BUN8 19 +Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10 0.4470474967907674 0.2585061619170484 0.7960162939813498 1.0 1.0 4 Q9Y6K9,Q7Z434,Q13546 3 +Traf6 mediated nf kb activation 0.4470474967907619 0.2585061619170319 0.7960162939813624 1.0 1.0 4 Q9Y6K9,Q7Z434,P09429 3 +Diseases of immune system 0.5878768441308476 0.2579507936439993 0.7964448832783502 1.0 1.0 2 Q9Y6K9 1 +Pyruvate metabolism and citric acid tca cycle 0.2900067944754562 0.2561220919735655 0.7978565638594208 1.0 1.0 34 P35613,P21796,Q13423 3 +Interactions of vpr with host cellular proteins 0.2887427411299671 0.2447708370465504 0.8066338757994793 1.0 1.0 34 P12236,P12235,Q8NFH4,Q9NRG9,Q99567,Q8NFH5,Q7Z3B4,Q9BTX1,P05141,Q96EE3,Q8N1F7 11 +Activation of the ap 1 family of transcription factors 0.5540583894770699 0.2351465793245906 0.8140949669977326 1.0 1.0 3 Q16539,P27361 2 +Thrombin signalling through proteinase activated receptors pars 0.5540583894770673 0.2351465793245843 0.8140949669977375 1.0 1.0 3 Q14344,P27361 2 +Runx2 regulates osteoblast differentiation 0.5540583894770671 0.235146579324584 0.8140949669977378 1.0 1.0 3 Q13951,P27361 2 +Creb1 phosphorylation through nmda receptor mediated activation of ras signaling 0.3523840844228671 0.2294124471043526 0.8185483627310548 1.0 1.0 10 Q14168,P07196 2 +Aberrant regulation of mitotic exit in cancer due to rb1 defects 0.3521195623515562 0.2281505016518494 0.8195292405673844 1.0 1.0 10 Q9UJX6,Q9UJX4,P30260,Q16763,Q9UJX3,Q9UJX5 6 +Runx1 regulates transcription of genes involved in differentiation of myeloid cells 0.574406670942909 0.2269866493590972 0.820434123509439 1.0 1.0 2 P17931 1 +Activation of rac1 0.4361360718870378 0.2265372317917222 0.8207836049999098 1.0 1.0 4 O94813,O96013,Q13177 3 +P38mapk events 0.569275176395119 0.2158116309541797 0.8291345817611613 1.0 1.0 2 P11233 1 +Nrage signals death through jnk 0.3863198458574067 0.2148875453903651 0.8298549954103098 1.0 1.0 6 P63000,Q14155,Q14344,Q9NY61,O75962 5 +Zbp1 dai mediated induction of type i ifns 0.4310012836970537 0.2120706961250996 0.8320518808384616 1.0 1.0 4 Q9NZI8,Q9Y6K9,Q13546 3 +Rip mediated nfkb activation via zbp1 0.4310012836970537 0.2120706961250996 0.8320518808384616 1.0 1.0 4 Q9NZI8,Q9Y6K9,Q13546 3 +Synthesis of pips at the plasma membrane 0.3484992829868951 0.2110068450609871 0.8328819300245165 1.0 1.0 10 Q96PE3,O00459,P61106,P20338,Q8TBX8 5 +Ldl clearance 0.3396912568088281 0.2025295974691624 0.8395027223742078 1.0 1.0 11 O15118 1 +Inla mediated entry of listeria monocytogenes into host cells 0.561898652982675 0.2003564205343706 0.841201839770831 1.0 1.0 2 O60716 1 +Interferon alpha beta signaling 0.3508361144248468 0.1925265397119958 0.8473297810693023 1.0 1.0 9 P10321,P04439,P18031 3 +Defective cftr causes cystic fibrosis 0.2830170225578855 0.1909459083098699 0.8485679721963812 1.0 1.0 40 P28074,P49721,O94905,Q9UBV2,Q9BUN8,O00231 6 +Abc transporter disorders 0.2830170225578854 0.1909459083098679 0.8485679721963828 1.0 1.0 40 P28074,P49721,O94905,Q9UBV2,Q9BUN8,O00231 6 +Neurotransmitter receptors and postsynaptic signal transmission 0.282703872077038 0.1892309367288891 0.8499118216668275 1.0 1.0 35 Q13885,Q9BVA1,Q9BUF5,Q14168,P07196,P52292,P68371 7 +G2 m dna replication checkpoint 0.5329436731271815 0.1876363730090131 0.8511617110988161 1.0 1.0 3 Q99640 1 +Rsk activation 0.4207317073170804 0.1842919222462071 0.8537844505116181 1.0 1.0 4 P28482,P27361,P51812 3 +Signal amplification 0.3750802825947307 0.1747411418736751 0.8612830385557184 1.0 1.0 6 Q16539,P04899,P63096,Q14344,P08754 5 +Fgfr1 mutant receptor activation 0.3686316688693078 0.1738638288680166 0.8619724800020654 1.0 1.0 7 O95684 1 +Cobalamin cbl vitamin b12 transport and metabolism 0.5248636509464345 0.1708800940406681 0.8643180490913362 1.0 1.0 3 Q99707,Q96EY8 2 +Defects in cobalamin b12 metabolism 0.5248636509464345 0.1708800940406681 0.8643180490913362 1.0 1.0 3 Q99707,Q96EY8 2 +Glutamate neurotransmitter release cycle 0.5168552124882165 0.1550685418546204 0.8767672821204437 1.0 1.0 3 O75915 1 +Syndecan interactions 0.4072528883183678 0.1502569298795765 0.8805619121138362 1.0 1.0 4 O14936,P06756,P05556 3 +Regulation of innate immune responses to cytosolic dna 0.5104266923323821 0.1429552342496652 0.8863255358701845 1.0 1.0 3 P19474,Q9UJV9 2 +Sumoylation of sumoylation proteins 0.2849672658462093 0.1420813936134617 0.8870157148133375 1.0 1.0 27 Q9NRG9,Q8NFH4,Q99567,Q8NFH5,Q7Z3B4,Q9BTX1,Q96EE3,Q8N1F7 8 +Sumoylation of ubiquitinylation proteins 0.2849672658462093 0.1420813936134617 0.8870157148133375 1.0 1.0 27 Q9NRG9,Q8NFH4,Q99567,Q8NFH5,Q7Z3B4,Q9BTX1,Q96EE3,Q8N1F7 8 +Regulation of glucokinase by glucokinase regulatory protein 0.2849672658462093 0.1420813936134617 0.8870157148133375 1.0 1.0 27 Q9NRG9,Q8NFH4,Q99567,Q8NFH5,Q7Z3B4,Q9BTX1,Q96EE3,Q8N1F7 8 +Activation of ppargc1a pgc 1alpha by phosphorylation 0.5075393006095724 0.1376831146854336 0.8904908648227514 1.0 1.0 3 Q16539,P54619 2 +Ptk6 regulates cell cycle 0.5224502886465613 0.1300359974854192 0.8965379465966854 1.0 1.0 2 P11802 1 +Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects 0.5224502886465613 0.1300359974854192 0.8965379465966854 1.0 1.0 2 P11802 1 +Clathrin mediated endocytosis 0.2620284707517538 0.1300151527680361 0.896554438274445 1.0 1.0 60 Q14108,Q96RU3,Q9BT78,Q9UHD9,Q92783,Q8N6T3,P11717,O14657,O43493,Q96D71,Q99627,P02786,P20645,Q9NY64,P61020 15 +Endosomal sorting complex required for transport escrt 0.3208005983156285 0.12952398923677 0.8969430441655344 1.0 1.0 12 Q9Y3E7,Q9H9H4,Q9UQN3 3 +Ripk1 mediated regulated necrosis 0.323107622385239 0.123755201696164 0.9015091029217656 1.0 1.0 11 P41440,O00560,Q14254,O75955,Q13546 5 +Hemostasis 0.3032650452844636 0.12073799141769 0.9038985663032126 1.0 1.0 115 Q92896,P20020,Q9NSK0,P35613,P18031,P16615,Q9NTK5,P42785,P23634,Q12846,P04350,Q14185,P78310,O94919,Q6UXV4,Q8NBX0,Q08722,O00459,P05556,O43852,Q9NZJ7,Q13885,Q9BVA1,P13473,Q8NCG7,Q9BUF5,Q08380,Q92520,O95140,Q9Y6I9,P68371 31 +Platelet activation signaling and aggregation 0.2698066313192322 0.1035242083889481 0.9175469371993116 1.0 1.0 50 O94919,Q6UXV4,P13473,Q8NBX0,Q8NCG7,Q9NTK5,O00459,Q08380,Q92520,O43852,Q9NZJ7,Q12846,P18031,Q9Y6I9 14 +Regulation of signaling by cbl 0.3841155591754888 0.0985514534848265 0.9214944167984572 1.0 1.0 4 O00459,P46108 2 +Free fatty acids regulate insulin secretion 0.491019884541365 0.0886023317832968 0.9293979548809326 1.0 1.0 2 O95573 1 +Rho gtpases activate nadph oxidases 0.3512038523274512 0.085280747828131 0.9320381967750953 1.0 1.0 5 Q16539,P63000,P27361,P28482 4 +Listeria monocytogenes entry into host cells 0.3284061696658227 0.0833228991669714 0.9335947927015816 1.0 1.0 8 Q92783,O60716,O14964,P62993,Q9NWH9,P42566,P35222 7 +Hcmv early events 0.2687219288011031 0.0661625733719181 0.947248393579025 1.0 1.0 44 Q13885,Q8NFH4,Q9BVA1,Q99567,Q8NFH5,Q9BUF5,P05556,Q7Z3B4,Q9BTX1,P04350,Q9NRG9,Q8N1F7,P68371 13 +Adrenaline noradrenaline inhibits insulin secretion 0.464400256574719 0.0628052635558861 0.9499215744347832 1.0 1.0 2 P04899 1 +Signaling by fgfr1 in disease 0.3201923878480204 0.054654147218879 0.9564139999440368 1.0 1.0 8 O95684 1 +Ecm proteoglycans 0.3603374894713316 0.0545357379692475 0.9565083361616752 1.0 1.0 4 Q14118 1 +Lysine catabolism 0.3334973481847734 0.0500310531819721 0.9600976424397298 1.0 1.0 7 Q9BQT8 1 +Constitutive signaling by overexpressed erbb2 0.4459416105229447 0.0498602322848168 0.960233767903077 1.0 1.0 3 P62993,Q16543 2 +Traf6 mediated irf7 activation 0.4467607440667078 0.0498561126290975 0.9602370508298236 1.0 1.0 2 Q7Z434 1 +Traf3 dependent irf activation pathway 0.4467607440667078 0.0498561126290975 0.9602370508298236 1.0 1.0 2 Q7Z434 1 +Dap12 signaling 0.3560918268121939 0.0476518241876479 0.9619937291806612 1.0 1.0 4 O00459 1 +Pi5p regulates tp53 acetylation 0.4377806286080756 0.0443879220393747 0.9645951889770752 1.0 1.0 2 Q8TBX8 1 +Activation of rac1 downstream of nmdars 0.4358563181526558 0.0433074698090249 0.9654564367641316 1.0 1.0 2 Q14155 1 +Dscam interactions 0.4358563181526527 0.043307469809023 0.9654564367641332 1.0 1.0 2 Q16539 1 +G alpha z signalling events 0.351091142490373 0.0399179671603583 0.968158526796544 1.0 1.0 4 P04899,P08754,P63096 3 +Signaling by hippo 0.3310854206807837 0.0397926916925476 0.968258402802698 1.0 1.0 6 Q4VCS5,Q9UDY2,P62258,P31946,Q07157 5 +Mastl facilitates mitotic progression 0.3475609756097601 0.0346999956633075 0.9723189643867388 1.0 1.0 4 P14635,P06493,P30154 3 +Citric acid cycle tca cycle 0.280108339371468 0.0332955414547209 0.973438909193936 1.0 1.0 18 P21912,Q13423 2 +Copii mediated vesicle transport 0.2647920081867372 0.0330481158774382 0.9736362176554488 1.0 1.0 31 Q9H0U4,P62820,Q15363,Q9HCU5,P53634,P49755,Q12907,O75396,P49257,Q13190 10 +Inlb mediated entry of listeria monocytogenes into host cell 0.3281952472703848 0.0322884227199346 0.9742420417234277 1.0 1.0 6 Q92783,O14964,P62993,Q9NWH9,P42566 5 +Activation of smo 0.4044259140474604 0.0296571173319122 0.9763405122762556 1.0 1.0 2 Q9Y496 1 +Phenylalanine metabolism 0.4241257619505978 0.0294049957555834 0.976541588492198 1.0 1.0 3 P09417,P61457 2 +Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1 0.391276459268757 0.0258360408800166 0.9793881149707426 1.0 1.0 2 P06493 1 +Myoclonic epilepsy of lafora 0.3877485567671508 0.0249656958744447 0.9800823258013864 1.0 1.0 2 P13807 1 +Thromboxane signalling through tp receptor 0.3745991019884458 0.0222232768425182 0.9822698499390392 1.0 1.0 2 Q14344 1 +Regulation of beta cell development 0.3379332477535386 0.0214697036359898 0.9828709708863884 1.0 1.0 4 Q13573,O00330,P31751 3 +Shc1 events in erbb2 signaling 0.3508659397049362 0.0189030040449975 0.9849184830886076 1.0 1.0 2 P62993 1 +Grb2 sos provides linkage to mapk signaling for integrins 0.2831943553559929 0.0157223122782895 0.9874559265723856 1.0 1.0 2 P62993 1 +Gaba b receptor activation 0.399422521655434 0.0120182774697841 0.990411032796765 1.0 1.0 3 P04899,P63096 2 +Adenylate cyclase inhibitory pathway 0.399422521655434 0.0120182774697841 0.990411032796765 1.0 1.0 3 P04899,P63096 2 +Adp signalling through p2y purinoceptor 12 0.399422521655434 0.0120182774697841 0.990411032796765 1.0 1.0 3 P04899,P63096 2 +Gaba receptor activation 0.399422521655434 0.0120182774697841 0.990411032796765 1.0 1.0 3 P04899,P63096 2 +Phosphorylation of emi1 0.389156239974328 0.0063805807813481 0.994909067649143 1.0 1.0 3 P53350,P06493 2 +Ub specific processing proteases 0.2499492221710009 0.0003559254181859 0.9997160126100282 1.0 1.0 69 P28074,P21796,Q9Y277,P45880 4 diff --git a/msigdb_reactome/selections.json b/msigdb_reactome/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..9bd8bb032fe5a2d3371631806cb84f26e55337a0 --- /dev/null +++ b/msigdb_reactome/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2 ltr circle formation", "A tetrasaccharide linker sequence is required for gag synthesis", "Abacavir metabolism", "Abacavir transmembrane transport", "Abacavir transport and metabolism", "Abc family proteins mediated transport", "Abc transporter disorders", "Abc transporters in lipid homeostasis", "Aberrant regulation of mitotic exit in cancer due to rb1 defects", "Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects", "Abortive elongation of hiv 1 transcript in the absence of tat", "Acetylcholine neurotransmitter release cycle", "Activated notch1 transmits signal to the nucleus", "Activated ntrk2 signals through cdk5", "Activated ntrk2 signals through frs2 and frs3", "Activated ntrk2 signals through fyn", "Activated ntrk2 signals through pi3k", "Activated ntrk2 signals through ras", "Activated ntrk3 signals through ras", "Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3", "Activated tak1 mediates p38 mapk activation", "Activation of ampk downstream of nmdars", "Activation of anterior hox genes in hindbrain development during early embryogenesis", "Activation of atr in response to replication stress", "Activation of bad and translocation to mitochondria", "Activation of bh3 only proteins", "Activation of gene expression by srebf srebp", "Activation of irf3 irf7 mediated by tbk1 ikk epsilon", "Activation of kainate receptors upon glutamate binding", "Activation of nima kinases nek9 nek6 nek7", "Activation of nmda receptors and postsynaptic events", "Activation of noxa and translocation to mitochondria", "Activation of ppargc1a pgc 1alpha by phosphorylation", "Activation of puma and translocation to mitochondria", "Activation of rac1", "Activation of rac1 downstream of nmdars", "Activation of smo", "Activation of the ap 1 family of transcription factors", "Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s", "Activation of the pre replicative complex", "Acyl chain remodeling of cl", "Acyl chain remodelling of pc", "Acyl chain remodelling of pg", "Acyl chain remodelling of pi", "Acyl chain remodelling of ps", "Adaptive immune system", "Adenylate cyclase inhibitory pathway", "Adherens junctions interactions", "Adora2b mediated anti inflammatory cytokines production", "Adp signalling through p2y purinoceptor 1", "Adp signalling through p2y purinoceptor 12", "Adrenaline noradrenaline inhibits insulin secretion", "Advanced glycosylation endproduct receptor signaling", "Aflatoxin activation and detoxification", "Aggrephagy", "Akt phosphorylates targets in the cytosol", "Akt phosphorylates targets in the nucleus", "Alk mutants bind tkis", "Alpha linolenic omega3 and linoleic omega6 acid metabolism", "Alpha oxidation of phytanate", "Alpha protein kinase 1 signaling pathway", "Amino acid transport across the plasma membrane", "Amino acids regulate mtorc1", "Ampk inhibits chrebp transcriptional activation activity", "Amyloid fiber formation", "Anchoring of the basal body to the plasma membrane", "Androgen biosynthesis", "Anti inflammatory response favouring leishmania parasite infection", "Antigen activates b cell receptor bcr leading to generation of second messengers", "Antigen presentation folding assembly and peptide loading of class i mhc", "Antigen processing cross presentation", "Antigen processing ubiquitination proteasome degradation", "Antimicrobial peptides", "Antiviral mechanism by ifn stimulated genes", "Apc c cdc20 mediated degradation of cyclin b", "Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1", "Apc c mediated degradation of cell cycle proteins", "Apc cdc20 mediated degradation of nek2a", "Apex1 independent resolution of ap sites via the single nucleotide replacement pathway", "Apobec3g mediated resistance to hiv 1 infection", "Apoptosis", "Apoptosis induced dna fragmentation", "Apoptotic cleavage of cell adhesion proteins", "Apoptotic cleavage of cellular proteins", "Apoptotic execution phase", "Apoptotic factor mediated response", "Aquaporin mediated transport", "Arachidonate production from dag", "Arachidonic acid metabolism", "Arms mediated activation", "Aryl hydrocarbon receptor signalling", "Asparagine n linked glycosylation", "Aspartate and asparagine metabolism", "Assembly and cell surface presentation of nmda receptors", "Assembly of active lpl and lipc lipase complexes", "Assembly of collagen fibrils and other multimeric structures", "Assembly of the hiv virion", "Assembly of the orc complex at the origin of replication", "Association of tric cct with target proteins during biosynthesis", "Asymmetric localization of pcp proteins", "Atf4 activates genes in response to endoplasmic reticulum stress", "Atf6 atf6 alpha activates chaperone genes", "Atf6 atf6 alpha activates chaperones", "Attachment and entry", "Attachment of gpi anchor to upar", "Attenuation phase", "Auf1 hnrnp d0 binds and destabilizes mrna", "Aurka activation by tpx2", "Autophagy", "B wich complex positively regulates rrna expression", "Base excision repair", "Base excision repair ap site formation", "Basigin interactions", "Bbsome mediated cargo targeting to cilium", "Beta catenin independent wnt signaling", "Beta catenin phosphorylation cascade", "Beta oxidation of butanoyl coa to acetyl coa", "Beta oxidation of decanoyl coa to octanoyl coa coa", "Beta oxidation of hexanoyl coa to butanoyl coa", "Beta oxidation of lauroyl coa to decanoyl coa coa", "Beta oxidation of octanoyl coa to hexanoyl coa", "Beta oxidation of pristanoyl coa", "Beta oxidation of very long chain fatty acids", "Bh3 only proteins associate with and inactivate anti apoptotic bcl 2 members", "Bicarbonate transporters", "Bile acid and bile salt metabolism", "Binding and uptake of ligands by scavenger receptors", "Binding of tcf lef ctnnb1 to target gene promoters", "Biological oxidations", "Biosynthesis of epa derived spms", "Biosynthesis of specialized proresolving mediators spms", "Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein", "Biotin transport and metabolism", "Blood group systems biosynthesis", "Bmal1 clock npas2 activates circadian gene expression", "Branched chain amino acid catabolism", "Budding and maturation of hiv virion", "Butyrate response factor 1 brf1 binds and destabilizes mrna", "C type lectin receptors clrs", "Ca dependent events", "Ca2 pathway", "Calnexin calreticulin cycle", "Camk iv mediated phosphorylation of creb", "Carboxyterminal post translational modifications of tubulin", "Cardiac conduction", "Cargo concentration in the er", "Cargo recognition for clathrin mediated endocytosis", "Cargo trafficking to the periciliary membrane", "Carnitine metabolism", "Caspase activation via death receptors in the presence of ligand", "Caspase activation via extrinsic apoptotic signalling pathway", "Caspase mediated cleavage of cytoskeletal proteins", "Cation coupled chloride cotransporters", "Cd163 mediating an anti inflammatory response", "Cd209 dc sign signaling", "Cd28 co stimulation", "Cd28 dependent pi3k akt signaling", "Cd28 dependent vav1 pathway", "Cdc42 gtpase cycle", "Cdc6 association with the orc origin complex", "Cdt1 association with the cdc6 orc origin complex", "Cell cell communication", "Cell cell junction organization", "Cell cycle", "Cell cycle checkpoints", "Cell cycle mitotic", "Cell death signalling via nrage nrif and nade", "Cell extracellular matrix interactions", "Cell junction organization", "Cell surface interactions at the vascular wall", "Cellular hexose transport", "Cellular response to chemical stress", "Cellular response to heat stress", "Cellular response to hypoxia", "Cellular response to starvation", "Cellular responses to stimuli", "Cellular senescence", "Chaperone mediated autophagy", "Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex", "Chl1 interactions", "Cholesterol biosynthesis", "Choline catabolism", "Chondroitin sulfate dermatan sulfate metabolism", "Chrebp activates metabolic gene expression", "Chromatin modifying enzymes", "Chromosome maintenance", "Chylomicron assembly", "Cilium assembly", "Circadian clock", "Citric acid cycle tca cycle", "Class a 1 rhodopsin like receptors", "Class b 2 secretin family receptors", "Class i mhc mediated antigen processing presentation", "Class i peroxisomal membrane protein import", "Clathrin mediated endocytosis", "Clec7a dectin 1 induces nfat activation", "Clec7a dectin 1 signaling", "Cobalamin cbl vitamin b12 transport and metabolism", "Coenzyme a biosynthesis", "Cohesin loading onto chromatin", "Collagen biosynthesis and modifying enzymes", "Collagen formation", "Competing endogenous rnas cernas regulate pten translation", "Complement cascade", "Complex i biogenesis", "Condensation of prometaphase chromosomes", "Condensation of prophase chromosomes", "Constitutive signaling by aberrant pi3k in cancer", "Constitutive signaling by akt1 e17k in cancer", "Constitutive signaling by egfrviii", "Constitutive signaling by ligand responsive egfr cancer variants", "Constitutive signaling by overexpressed erbb2", "Conversion from apc c cdc20 to apc c cdh1 in late anaphase", "Cooperation of pdcl phlp1 and tric cct in g protein beta folding", "Cooperation of prefoldin and tric cct in actin and tubulin folding", "Copi dependent golgi to er retrograde traffic", "Copi independent golgi to er retrograde traffic", "Copi mediated anterograde transport", "Copii mediated vesicle transport", "Costimulation by the cd28 family", "Creatine metabolism", "Creb phosphorylation", "Creb1 phosphorylation through nmda receptor mediated activation of ras signaling", "Creb1 phosphorylation through the activation of adenylate cyclase", "Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde", "Cristae formation", "Crmps in sema3a signaling", "Cross presentation of particulate exogenous antigens phagosomes", "Cross presentation of soluble exogenous antigens endosomes", "Cs ds degradation", "Ctla4 inhibitory signaling", "Cyclin a b1 b2 associated events during g2 m transition", "Cyclin a cdk2 associated events at s phase entry", "Cyclin d associated events in g1", "Cytochrome c mediated apoptotic response", "Cytochrome p450 arranged by substrate type", "Cytokine signaling in immune system", "Cytoprotection by hmox1", "Cytosolic iron sulfur cluster assembly", "Cytosolic sensors of pathogen associated dna", "Cytosolic sulfonation of small molecules", "Cytosolic trna aminoacylation", "Dag and ip3 signaling", "Dap12 interactions", "Dap12 signaling", "Darpp 32 events", "Dcc mediated attractive signaling", "Ddx58 ifih1 mediated induction of interferon alpha beta", "Deactivation of the beta catenin transactivating complex", "Deadenylation dependent mrna decay", "Deadenylation of mrna", "Death receptor signalling", "Dectin 1 mediated noncanonical nf kb signaling", "Defective cftr causes cystic fibrosis", "Defective chst14 causes eds musculocontractural type", "Defective factor ix causes hemophilia b", "Defective intrinsic pathway for apoptosis", "Defective ripk1 mediated regulated necrosis", "Defects in biotin btn metabolism", "Defects in cobalamin b12 metabolism", "Defects in vitamin and cofactor metabolism", "Defects of contact activation system cas and kallikrein kinin system kks", "Degradation of axin", "Degradation of beta catenin by the destruction complex", "Degradation of cysteine and homocysteine", "Degradation of dvl", "Degradation of gli1 by the proteasome", "Degradation of the extracellular matrix", "Depolymerisation of the nuclear lamina", "Deposition of new cenpa containing nucleosomes at the centromere", "Dermatan sulfate biosynthesis", "Detoxification of reactive oxygen species", "Deubiquitination", "Developmental biology", "Dex h box helicases activate type i ifn and inflammatory cytokines production", "Digestion", "Digestion and absorption", "Disassembly of the destruction complex and recruitment of axin to the membrane", "Diseases associated with glycosaminoglycan metabolism", "Diseases associated with glycosylation precursor biosynthesis", "Diseases associated with n glycosylation of proteins", "Diseases associated with o glycosylation of proteins", "Diseases of carbohydrate metabolism", "Diseases of dna repair", "Diseases of glycosylation", "Diseases of immune system", "Diseases of metabolism", "Diseases of mismatch repair mmr", "Diseases of mitotic cell cycle", "Diseases of programmed cell death", "Diseases of signal transduction by growth factor receptors and second messengers", "Disinhibition of snare formation", "Disorders of transmembrane transporters", "Displacement of dna glycosylase by apex1", "Dissolution of fibrin clot", "Dna damage bypass", "Dna damage recognition in gg ner", "Dna damage reversal", "Dna damage telomere stress induced senescence", "Dna double strand break repair", "Dna double strand break response", "Dna methylation", "Dna repair", "Dna replication", "Dna replication initiation", "Dna replication pre initiation", "Dna strand elongation", "Dopamine clearance from the synaptic cleft", "Dopamine neurotransmitter release cycle", "Downregulation of erbb2 erbb3 signaling", "Downregulation of erbb2 signaling", "Downregulation of smad2 3 smad4 transcriptional activity", "Downregulation of tgf beta receptor signaling", "Downstream signal transduction", "Downstream signaling events of b cell receptor bcr", "Downstream signaling of activated fgfr1", "Downstream signaling of activated fgfr2", "Downstream signaling of activated fgfr3", "Downstream signaling of activated fgfr4", "Dscam interactions", "Dual incision in gg ner", "Dual incision in tc ner", "E2f enabled inhibition of pre replication complex formation", "E2f mediated regulation of dna replication", "E3 ubiquitin ligases ubiquitinate target proteins", "Early phase of hiv life cycle", "Ecm proteoglycans", "Effects of pip2 hydrolysis", "Egfr downregulation", "Egfr interacts with phospholipase c gamma", "Egfr transactivation by gastrin", "Egr2 and sox10 mediated initiation of schwann cell myelination", "Elastic fibre formation", "Endogenous sterols", "Endosomal sorting complex required for transport escrt", "Endosomal vacuolar pathway", "Energy dependent regulation of mtor by lkb1 ampk", "Enos activation", "Eph ephrin mediated repulsion of cells", "Eph ephrin signaling", "Epha mediated growth cone collapse", "Ephb mediated forward signaling", "Ephrin signaling", "Epigenetic regulation of gene expression", "Er quality control compartment erqc", "Er to golgi anterograde transport", "Erbb2 regulates cell motility", "Ercc6 csb and ehmt2 g9a positively regulate rrna expression", "Erk mapk targets", "Erks are inactivated", "Erythrocytes take up carbon dioxide and release oxygen", "Erythropoietin activates phospholipase c gamma plcg", "Erythropoietin activates ras", "Esr mediated signaling", "Establishment of sister chromatid cohesion", "Estrogen biosynthesis", "Estrogen dependent gene expression", "Estrogen dependent nuclear events downstream of esr membrane signaling", "Estrogen stimulated signaling through prkcz", "Ethanol oxidation", "Eukaryotic translation elongation", "Eukaryotic translation initiation", "Export of viral ribonucleoproteins from nucleus", "Extension of telomeres", "Extra nuclear estrogen signaling", "Extracellular matrix organization", "Factors involved in megakaryocyte development and platelet production", "Fanconi anemia pathway", "Fasl cd95l signaling", "Fatty acid metabolism", "Fatty acyl coa biosynthesis", "Fbxw7 mutants and notch1 in cancer", "Fc epsilon receptor fceri signaling", "Fceri mediated ca 2 mobilization", "Fceri mediated mapk activation", "Fceri mediated nf kb activation", "Fcgamma receptor fcgr dependent phagocytosis", "Fcgr3a mediated il10 synthesis", "Fgfr1 mutant receptor activation", "Fgfr2 alternative splicing", "Fgfr2 mutant receptor activation", "Fibronectin matrix formation", "Flt3 signaling", "Flt3 signaling in disease", "Folding of actin by cct tric", "Formation of apoptosome", "Formation of atp by chemiosmotic coupling", "Formation of fibrin clot clotting cascade", "Formation of incision complex in gg ner", "Formation of rna pol ii elongation complex", "Formation of senescence associated heterochromatin foci sahf", "Formation of tc ner pre incision complex", "Formation of the beta catenin tcf transactivating complex", "Formation of the cornified envelope", "Formation of the early elongation complex", "Formation of tubulin folding intermediates by cct tric", "Formation of xylulose 5 phosphate", "Formyl peptide receptors bind formyl peptides and many other ligands", "Foxo mediated transcription", "Foxo mediated transcription of oxidative stress metabolic and neuronal genes", "Free fatty acids regulate insulin secretion", "Frs mediated fgfr1 signaling", "Frs mediated fgfr2 signaling", "Frs mediated fgfr3 signaling", "Frs mediated fgfr4 signaling", "Fructose catabolism", "Fructose metabolism", "G alpha 12 13 signalling events", "G alpha i signalling events", "G alpha q signalling events", "G alpha s signalling events", "G alpha z signalling events", "G beta gamma signalling through cdc42", "G beta gamma signalling through pi3kgamma", "G protein beta gamma signalling", "G protein mediated events", "G0 and early g1", "G1 s dna damage checkpoints", "G1 s specific transcription", "G2 m checkpoints", "G2 m dna damage checkpoint", "G2 m dna replication checkpoint", "G2 phase", "Gab1 signalosome", "Gaba b receptor activation", "Gaba receptor activation", "Gaba synthesis release reuptake and degradation", "Galactose catabolism", "Gamma carboxylation hypusine formation and arylsulfatase activation", "Gamma carboxylation transport and amino terminal cleavage of proteins", "Gap filling dna repair synthesis and ligation in gg ner", "Gap junction assembly", "Gap junction degradation", "Gap junction trafficking and regulation", "Gastrin creb signalling pathway via pkc and mapk", "Gene and protein expression by jak stat signaling after interleukin 12 stimulation", "Gene silencing by rna", "Generation of second messenger molecules", "Global genome nucleotide excision repair gg ner", "Glucagon like peptide 1 glp1 regulates insulin secretion", "Glucagon signaling in metabolic regulation", "Gluconeogenesis", "Glucose metabolism", "Glucuronidation", "Glutamate and glutamine metabolism", "Glutamate neurotransmitter release cycle", "Glutathione conjugation", "Glutathione synthesis and recycling", "Glycerophospholipid biosynthesis", "Glycerophospholipid catabolism", "Glycogen breakdown glycogenolysis", "Glycogen metabolism", "Glycogen storage diseases", "Glycogen synthesis", "Glycolysis", "Glycosaminoglycan metabolism", "Glycosphingolipid metabolism", "Glyoxylate metabolism and glycine degradation", "Golgi associated vesicle biogenesis", "Golgi cisternae pericentriolar stack reorganization", "Golgi to er retrograde transport", "Gp1b ix v activation signalling", "Gpcr ligand binding", "Gpvi mediated activation cascade", "Grb2 events in erbb2 signaling", "Grb2 sos provides linkage to mapk signaling for integrins", "Growth hormone receptor signaling", "Hats acetylate histones", "Hcmv early events", "Hcmv infection", "Hcmv late events", "Hdacs deacetylate histones", "Hdl assembly", "Hdl clearance", "Hdms demethylate histones", "Hdr through homologous recombination hrr", "Hdr through mmej alt nhej", "Hdr through single strand annealing ssa", "Hedgehog ligand biogenesis", "Hedgehog off state", "Hedgehog on state", "Heme biosynthesis", "Heme degradation", "Heme signaling", "Hemostasis", "Heparan sulfate heparin hs gag metabolism", "Hiv elongation arrest and recovery", "Hiv infection", "Hiv life cycle", "Hiv transcription elongation", "Hiv transcription initiation", "Homologous dna pairing and strand exchange", "Homology directed repair", "Host interactions of hiv factors", "Hs gag biosynthesis", "Hs gag degradation", "Hsf1 activation", "Hsf1 dependent transactivation", "Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand", "Hur elavl1 binds and stabilizes mrna", "Hyaluronan metabolism", "Hyaluronan uptake and degradation", "Hydrolysis of lpc", "Ikba variant leads to eda id", "Ikk complex recruitment mediated by rip1", "Immunoregulatory interactions between a lymphoid and a non lymphoid cell", "Inactivation of cdc42 and rac1", "Inactivation of csf3 g csf signaling", "Incretin synthesis secretion and inactivation", "Infection with mycobacterium tuberculosis", "Infectious disease", "Inflammasomes", "Influenza infection", "Inhibition of dna recombination at telomere", "Inhibition of replication initiation of damaged dna by rb1 e2f1", "Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components", "Initiation of nuclear envelope ne reformation", "Inla mediated entry of listeria monocytogenes into host cells", "Inlb mediated entry of listeria monocytogenes into host cell", "Innate immune system", "Inositol phosphate metabolism", "Insertion of tail anchored proteins into the endoplasmic reticulum membrane", "Insulin processing", "Insulin receptor recycling", "Insulin receptor signalling cascade", "Integration of energy metabolism", "Integration of provirus", "Integrin cell surface interactions", "Integrin signaling", "Interaction between l1 and ankyrins", "Interactions of rev with host cellular proteins", "Interactions of vpr with host cellular proteins", "Interconversion of nucleotide di and triphosphates", "Interferon alpha beta signaling", "Interferon gamma signaling", "Interferon signaling", "Interleukin 1 family signaling", "Interleukin 1 signaling", "Interleukin 10 signaling", "Interleukin 12 family signaling", "Interleukin 12 signaling", "Interleukin 15 signaling", "Interleukin 17 signaling", "Interleukin 2 family signaling", "Interleukin 20 family signaling", "Interleukin 21 signaling", "Interleukin 23 signaling", "Interleukin 27 signaling", "Interleukin 3 interleukin 5 and gm csf signaling", "Interleukin 35 signalling", "Interleukin 37 signaling", "Interleukin 4 and interleukin 13 signaling", "Interleukin 6 family signaling", "Interleukin 6 signaling", "Interleukin 7 signaling", "Interleukin 9 signaling", "Interleukin receptor shc signaling", "Intra golgi and retrograde golgi to er traffic", "Intra golgi traffic", "Intracellular signaling by second messengers", "Intraflagellar transport", "Intrinsic pathway for apoptosis", "Intrinsic pathway of fibrin clot formation", "Ion channel transport", "Ion homeostasis", "Ion transport by p type atpases", "Ionotropic activity of kainate receptors", "Irak1 recruits ikk complex", "Irak2 mediated activation of tak1 complex", "Irak4 deficiency tlr2 4", "Ire1alpha activates chaperones", "Irf3 mediated activation of type 1 ifn", "Irf3 mediated induction of type i ifn", "Iron uptake and transport", "Irs mediated signalling", "Jnk c jun kinases phosphorylation and activation mediated by activated human tak1", "Josephin domain dubs", "Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Keratan sulfate keratin metabolism", "Keratinization", "Ketone body metabolism", "Killing mechanisms", "Kinesins", "Ksrp khsrp binds and destabilizes mrna", "L1cam interactions", "Lagging strand synthesis", "Laminin interactions", "Late endosomal microautophagy", "Ldl clearance", "Ldl remodeling", "Leishmania infection", "Lgi adam interactions", "Linoleic acid la metabolism", "Lipophagy", "Listeria monocytogenes entry into host cells", "Long term potentiation", "Loss of function of mecp2 in rett syndrome", "Loss of mecp2 binding ability to the ncor smrt complex", "Lrr flii interacting protein 1 lrrfip1 activates type i ifn production", "Lysine catabolism", "Lysosome vesicle biogenesis", "M phase", "Map2k and mapk activation", "Map3k8 tpl2 dependent mapk1 3 activation", "Mapk family signaling cascades", "Mapk targets nuclear events mediated by map kinases", "Mapk1 erk2 activation", "Mapk3 erk1 activation", "Mapk6 mapk4 signaling", "Mastl facilitates mitotic progression", "Maturation of protein 3a", "Maturation of sars cov 1 nucleoprotein", "Maturation of sars cov 1 spike protein", "Maturation of sars cov 2 nucleoprotein", "Maturation of sars cov 2 spike protein", "Mecp2 regulates neuronal receptors and channels", "Mecp2 regulates transcription factors", "Mecp2 regulates transcription of neuronal ligands", "Meiosis", "Meiotic recombination", "Meiotic synapsis", "Membrane trafficking", "Met activates pi3k akt signaling", "Met activates ptk2 signaling", "Met activates ptpn11", "Met activates rap1 and rac1", "Met activates ras signaling", "Met interacts with tns proteins", "Met promotes cell motility", "Met receptor activation", "Met receptor recycling", "Metabolic disorders of biological oxidation enzymes", "Metabolism of amino acids and derivatives", "Metabolism of angiotensinogen to angiotensins", "Metabolism of carbohydrates", "Metabolism of cofactors", "Metabolism of fat soluble vitamins", "Metabolism of folate and pterines", "Metabolism of ingested semet sec mesec into h2se", "Metabolism of lipids", "Metabolism of nitric oxide nos3 activation and regulation", "Metabolism of nucleotides", "Metabolism of polyamines", "Metabolism of porphyrins", "Metabolism of rna", "Metabolism of steroid hormones", "Metabolism of steroids", "Metabolism of vitamins and cofactors", "Metabolism of water soluble vitamins and cofactors", "Metal ion slc transporters", "Metalloprotease dubs", "Methionine salvage pathway", "Methylation", "Mhc class ii antigen presentation", "Microrna mirna biogenesis", "Miro gtpase cycle", "Miscellaneous transport and binding events", "Mismatch repair", "Mitochondrial biogenesis", "Mitochondrial calcium ion transport", "Mitochondrial fatty acid beta oxidation", "Mitochondrial fatty acid beta oxidation of saturated fatty acids", "Mitochondrial fatty acid beta oxidation of unsaturated fatty acids", "Mitochondrial iron sulfur cluster biogenesis", "Mitochondrial protein import", "Mitochondrial translation", "Mitochondrial trna aminoacylation", "Mitophagy", "Mitotic g1 phase and g1 s transition", "Mitotic g2 g2 m phases", "Mitotic metaphase and anaphase", "Mitotic prometaphase", "Mitotic prophase", "Mitotic spindle checkpoint", "Mitotic telophase cytokinesis", "Molecules associated with elastic fibres", "Molybdenum cofactor biosynthesis", "Mrna capping", "Mrna decay by 3 to 5 exoribonuclease", "Mrna decay by 5 to 3 exoribonuclease", "Mrna editing", "Mrna splicing", "Mrna splicing minor pathway", "Mtor signalling", "Mtorc1 mediated signalling", "Mucopolysaccharidoses", "Muscle contraction", "Myd88 independent tlr4 cascade", "Myoclonic epilepsy of lafora", "Myogenesis", "N glycan antennae elongation", "N glycan antennae elongation in the medial trans golgi", "N glycan trimming and elongation in the cis golgi", "N glycan trimming in the er and calnexin calreticulin cycle", "Nade modulates death signalling", "Ncam signaling for neurite out growth", "Neddylation", "Nef and signal transduction", "Nef mediated cd4 down regulation", "Nef mediated cd8 down regulation", "Nef mediated downregulation of mhc class i complex cell surface expression", "Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters", "Negative epigenetic regulation of rrna expression", "Negative feedback regulation of mapk pathway", "Negative regulation of fgfr1 signaling", "Negative regulation of fgfr2 signaling", "Negative regulation of fgfr3 signaling", "Negative regulation of fgfr4 signaling", "Negative regulation of flt3", "Negative regulation of mapk pathway", "Negative regulation of met activity", "Negative regulation of nmda receptor mediated neuronal transmission", "Negative regulation of notch4 signaling", "Negative regulation of the pi3k akt network", "Negative regulators of ddx58 ifih1 signaling", "Nephrin family interactions", "Nervous system development", "Netrin 1 signaling", "Netrin mediated repulsion signals", "Neurexins and neuroligins", "Neurofascin interactions", "Neuronal system", "Neurotransmitter clearance", "Neurotransmitter receptors and postsynaptic signal transmission", "Neurotransmitter release cycle", "Neutrophil degranulation", "Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10", "Nf kb is activated and signals survival", "Ngf stimulated transcription", "Nicotinamide salvaging", "Nicotinate metabolism", "Nod1 2 signaling pathway", "Non integrin membrane ecm interactions", "Noncanonical activation of notch3", "Nonhomologous end joining nhej", "Nonsense mediated decay nmd", "Norepinephrine neurotransmitter release cycle", "Nostrin mediated enos trafficking", "Notch hlh transcription pathway", "Notch1 intracellular domain regulates transcription", "Notch2 activation and transmission of signal to the nucleus", "Notch2 intracellular domain regulates transcription", "Notch3 activation and transmission of signal to the nucleus", "Notch3 intracellular domain regulates transcription", "Notch4 activation and transmission of signal to the nucleus", "Notch4 intracellular domain regulates transcription", "Nr1h2 and nr1h3 mediated signaling", "Nr1h2 nr1h3 regulate gene expression linked to lipogenesis", "Nr1h2 nr1h3 regulate gene expression to control bile acid homeostasis", "Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux", "Nrage signals death through jnk", "Nrcam interactions", "Nrif signals cell death from the nucleus", "Ns1 mediated effects on host pathways", "Ntrk2 activates rac1", "Nuclear envelope breakdown", "Nuclear envelope ne reassembly", "Nuclear events kinase and transcription factor activation", "Nuclear events stimulated by alk signaling in cancer", "Nuclear import of rev protein", "Nuclear pore complex npc disassembly", "Nuclear receptor transcription pathway", "Nuclear signaling by erbb4", "Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways", "Nucleotide biosynthesis", "Nucleotide catabolism", "Nucleotide excision repair", "Nucleotide salvage", "O linked glycosylation", "O linked glycosylation of mucins", "Oas antiviral response", "Oncogene induced senescence", "Oncogenic mapk signaling", "Opioid signalling", "Orc1 removal from chromatin", "Organelle biogenesis and maintenance", "Organic anion transporters", "Other interleukin signaling", "Other semaphorin interactions", "Ovarian tumor domain proteases", "Oxidative stress induced senescence", "P130cas linkage to mapk signaling for integrins", "P38mapk events", "P75 ntr receptor mediated signalling", "P75ntr negatively regulates cell cycle via sc1", "P75ntr recruits signalling complexes", "P75ntr regulates axonogenesis", "P75ntr signals via nf kb", "Parasite infection", "Passive transport by aquaporins", "Pcna dependent long patch base excision repair", "Pcp ce pathway", "Pd 1 signaling", "Pecam1 interactions", "Pentose phosphate pathway", "Peptide hormone metabolism", "Peptide ligand binding receptors", "Perk regulates gene expression", "Peroxisomal lipid metabolism", "Peroxisomal protein import", "Pexophagy", "Phase 0 rapid depolarisation", "Phase 2 plateau phase", "Phase 3 rapid repolarisation", "Phase i functionalization of compounds", "Phase ii conjugation of compounds", "Phenylalanine and tyrosine metabolism", "Phenylalanine metabolism", "Phosphate bond hydrolysis by nudt proteins", "Phospholipase c mediated cascade fgfr2", "Phospholipase c mediated cascade fgfr4", "Phospholipid metabolism", "Phosphorylation of emi1", "Phosphorylation of the apc c", "Pi 3k cascade fgfr1", "Pi 3k cascade fgfr2", "Pi 3k cascade fgfr3", "Pi 3k cascade fgfr4", "Pi metabolism", "Pi3k akt activation", "Pi3k akt signaling in cancer", "Pi3k events in erbb2 signaling", "Pi5p regulates tp53 acetylation", "Pink1 prkn mediated mitophagy", "Piwi interacting rna pirna biogenesis", "Pka activation in glucagon signalling", "Pka mediated phosphorylation of creb", "Pka mediated phosphorylation of key metabolic factors", "Pkmts methylate histone lysines", "Plasma lipoprotein assembly", "Plasma lipoprotein assembly remodeling and clearance", "Plasma lipoprotein clearance", "Plasma lipoprotein remodeling", "Platelet activation signaling and aggregation", "Platelet adhesion to exposed collagen", "Platelet aggregation plug formation", "Platelet calcium homeostasis", "Platelet homeostasis", "Platelet sensitization by ldl", "Polb dependent long patch base excision repair", "Polo like kinase mediated events", "Polymerase switching", "Polymerase switching on the c strand of the telomere", "Positive epigenetic regulation of rrna expression", "Post chaperonin tubulin folding pathway", "Post translational modification synthesis of gpi anchored proteins", "Post translational protein modification", "Postmitotic nuclear pore complex npc reformation", "Potential therapeutics for sars", "Pou5f1 oct4 sox2 nanog activate genes related to proliferation", "Pp2a mediated dephosphorylation of key metabolic factors", "Prc2 methylates histones and dna", "Pre notch expression and processing", "Pre notch processing in golgi", "Pre notch processing in the endoplasmic reticulum", "Pregnenolone biosynthesis", "Prevention of phagosomal lysosomal fusion", "Processing and activation of sumo", "Processing of capped intron containing pre mrna", "Processing of capped intronless pre mrna", "Processing of dna double strand break ends", "Processing of intronless pre mrnas", "Processing of smdt1", "Processive synthesis on the c strand of the telomere", "Processive synthesis on the lagging strand", "Programmed cell death", "Prolactin receptor signaling", "Prolonged erk activation events", "Propionyl coa catabolism", "Protein folding", "Protein localization", "Protein methylation", "Protein protein interactions at synapses", "Protein repair", "Protein ubiquitination", "Proton coupled monocarboxylate transport", "Pten regulation", "Ptk6 expression", "Ptk6 regulates cell cycle", "Ptk6 regulates proteins involved in rna processing", "Ptk6 regulates rho gtpases ras gtpase and map kinases", "Purine catabolism", "Purine ribonucleoside monophosphate biosynthesis", "Purine salvage", "Purinergic signaling in leishmaniasis infection", "Pyrimidine catabolism", "Pyrimidine salvage", "Pyroptosis", "Pyruvate metabolism", "Pyruvate metabolism and citric acid tca cycle", "Ra biosynthesis pathway", "Rab gefs exchange gtp for gdp on rabs", "Rab geranylgeranylation", "Rab regulation of trafficking", "Rac1 gtpase cycle", "Rac2 gtpase cycle", "Rac3 gtpase cycle", "Raf activation", "Raf independent mapk1 3 activation", "Rap1 signalling", "Ras activation upon ca2 influx through nmda receptor", "Ras processing", "Ras signaling downstream of nf1 loss of function variants", "Reactions specific to the complex n glycan synthesis pathway", "Receptor mediated mitophagy", "Receptor type tyrosine protein phosphatases", "Recognition and association of dna glycosylase with site containing an affected purine", "Recognition of dna damage by pcna containing replication complex", "Recruitment of mitotic centrosome proteins and complexes", "Recruitment of numa to mitotic centrosomes", "Recycling of eif2 gdp", "Recycling pathway of l1", "Reduction of cytosolic ca levels", "Regulated necrosis", "Regulated proteolysis of p75ntr", "Regulation by c flip", "Regulation of bach1 activity", "Regulation of beta cell development", "Regulation of cholesterol biosynthesis by srebp srebf", "Regulation of commissural axon pathfinding by slit and robo", "Regulation of cytoskeletal remodeling and cell spreading by ipp complex components", "Regulation of expression of slits and robos", "Regulation of foxo transcriptional activity by acetylation", "Regulation of gene expression in beta cells", "Regulation of gene expression in early pancreatic precursor cells", "Regulation of gene expression in late stage branching morphogenesis pancreatic bud precursor cells", "Regulation of glucokinase by glucokinase regulatory protein", "Regulation of glycolysis by fructose 2 6 bisphosphate metabolism", "Regulation of hmox1 expression and activity", "Regulation of hsf1 mediated heat shock response", "Regulation of ifna signaling", "Regulation of ifng signaling", "Regulation of innate immune responses to cytosolic dna", "Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps", "Regulation of insulin secretion", "Regulation of kit signaling", "Regulation of lipid metabolism by pparalpha", "Regulation of localization of foxo transcription factors", "Regulation of mecp2 expression and activity", "Regulation of mrna stability by proteins that bind au rich elements", "Regulation of plk1 activity at g2 m transition", "Regulation of pten gene transcription", "Regulation of pten localization", "Regulation of pten mrna translation", "Regulation of pten stability and activity", "Regulation of pyruvate dehydrogenase pdh complex", "Regulation of ras by gaps", "Regulation of runx1 expression and activity", "Regulation of runx2 expression and activity", "Regulation of runx3 expression and activity", "Regulation of signaling by cbl", "Regulation of tlr by endogenous ligand", "Regulation of tnfr1 signaling", "Regulation of tp53 activity", "Regulation of tp53 activity through acetylation", "Regulation of tp53 activity through association with co factors", "Regulation of tp53 activity through methylation", "Regulation of tp53 activity through phosphorylation", "Regulation of tp53 expression and degradation", "Release of apoptotic factors from the mitochondria", "Repression of wnt target genes", "Reproduction", "Resolution of abasic sites ap sites", "Resolution of ap sites via the multiple nucleotide patch replacement pathway", "Resolution of d loop structures", "Resolution of d loop structures through synthesis dependent strand annealing sdsa", "Resolution of sister chromatid cohesion", "Respiratory electron transport", "Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins", "Response of eif2ak1 hri to heme deficiency", "Response of eif2ak4 gcn2 to amino acid deficiency", "Response of mtb to phagocytosis", "Response to elevated platelet cytosolic ca2", "Ret signaling", "Retrograde neurotrophin signalling", "Retrograde transport at the trans golgi network", "Rho gtpase cycle", "Rho gtpase effectors", "Rho gtpases activate cit", "Rho gtpases activate formins", "Rho gtpases activate iqgaps", "Rho gtpases activate ktn1", "Rho gtpases activate nadph oxidases", "Rho gtpases activate paks", "Rho gtpases activate pkns", "Rho gtpases activate rhotekin and rhophilins", "Rho gtpases activate rocks", "Rho gtpases activate wasps and waves", "Rhoa gtpase cycle", "Rhob gtpase cycle", "Rhobtb gtpase cycle", "Rhobtb1 gtpase cycle", "Rhobtb2 gtpase cycle", "Rhobtb3 atpase cycle", "Rhoc gtpase cycle", "Rhod gtpase cycle", "Rhof gtpase cycle", "Rhog gtpase cycle", "Rhoh gtpase cycle", "Rhoj gtpase cycle", "Rhoq gtpase cycle", "Rhot1 gtpase cycle", "Rhou gtpase cycle", "Rhov gtpase cycle", "Rip mediated nfkb activation via zbp1", "Ripk1 mediated regulated necrosis", "Rmts methylate histone arginines", "Rna polymerase i promoter escape", "Rna polymerase i transcription", "Rna polymerase i transcription initiation", "Rna polymerase i transcription termination", "Rna polymerase ii transcribes snrna genes", "Rna polymerase ii transcription", "Rna polymerase ii transcription termination", "Rna polymerase iii chain elongation", "Rna polymerase iii transcription", "Rna polymerase iii transcription initiation from type 1 promoter", "Rna polymerase iii transcription initiation from type 3 promoter", "Rna polymerase iii transcription termination", "Rnd1 gtpase cycle", "Rnd2 gtpase cycle", "Rnd3 gtpase cycle", "Robo receptors bind akap5", "Role of abl in robo slit signaling", "Role of lat2 ntal lab on calcium mobilization", "Role of phospholipids in phagocytosis", "Role of second messengers in netrin 1 signaling", "Rora activates gene expression", "Ros and rns production in phagocytes", "Rrna modification in the mitochondrion", "Rrna modification in the nucleus and cytosol", "Rrna processing", "Rrna processing in the mitochondrion", "Rsk activation", "Runx1 and foxp3 control the development of regulatory t lymphocytes tregs", "Runx1 interacts with co factors whose precise effect on runx1 targets is not known", "Runx1 regulates estrogen receptor mediated transcription", "Runx1 regulates expression of components of tight junctions", "Runx1 regulates genes involved in megakaryocyte differentiation and platelet function", "Runx1 regulates transcription of genes involved in bcr signaling", "Runx1 regulates transcription of genes involved in differentiation of hscs", "Runx1 regulates transcription of genes involved in differentiation of keratinocytes", "Runx1 regulates transcription of genes involved in differentiation of myeloid cells", "Runx1 regulates transcription of genes involved in interleukin signaling", "Runx1 regulates transcription of genes involved in wnt signaling", "Runx2 regulates bone development", "Runx2 regulates chondrocyte maturation", "Runx2 regulates genes involved in cell migration", "Runx2 regulates osteoblast differentiation", "Runx3 regulates cdkn1a transcription", "Runx3 regulates immune response and cell migration", "Runx3 regulates notch signaling", "Runx3 regulates p14 arf", "Runx3 regulates wnt signaling", "S phase", "Sars cov 1 infection", "Sars cov 2 infection", "Sars cov infections", "Scavenging by class a receptors", "Scavenging by class b receptors", "Scavenging by class f receptors", "Scf skp2 mediated degradation of p27 p21", "Sealing of the nuclear envelope ne by escrt iii", "Selective autophagy", "Selenoamino acid metabolism", "Sema3a pak dependent axon repulsion", "Sema3a plexin repulsion signaling by inhibiting integrin adhesion", "Sema4d in semaphorin signaling", "Sema4d induced cell migration and growth cone collapse", "Sema4d mediated inhibition of cell attachment and migration", "Semaphorin interactions", "Senescence associated secretory phenotype sasp", "Sensing of dna double strand breaks", "Sensory perception", "Sensory processing of sound", "Sensory processing of sound by outer hair cells of the cochlea", "Separation of sister chromatids", "Serine biosynthesis", "Serotonin neurotransmitter release cycle", "Shc mediated cascade fgfr1", "Shc mediated cascade fgfr3", "Shc mediated cascade fgfr4", "Shc related events triggered by igf1r", "Shc1 events in egfr signaling", "Shc1 events in erbb2 signaling", "Shc1 events in erbb4 signaling", "Sialic acid metabolism", "Signal amplification", "Signal attenuation", "Signal regulatory protein family interactions", "Signal transduction by l1", "Signaling by activin", "Signaling by alk", "Signaling by alk in cancer", "Signaling by bmp", "Signaling by braf and raf1 fusions", "Signaling by csf3 g csf", "Signaling by ctnnb1 phospho site mutants", "Signaling by cytosolic fgfr1 fusion mutants", "Signaling by egfr", "Signaling by egfr in cancer", "Signaling by erbb2", "Signaling by erbb2 ecd mutants", "Signaling by erbb2 in cancer", "Signaling by erbb4", "Signaling by erythropoietin", "Signaling by fgfr", "Signaling by fgfr in disease", "Signaling by fgfr1", "Signaling by fgfr1 in disease", "Signaling by fgfr2", "Signaling by fgfr2 iiia tm", "Signaling by fgfr2 in disease", "Signaling by fgfr3", "Signaling by fgfr3 fusions in cancer", "Signaling by fgfr4", "Signaling by fgfr4 in disease", "Signaling by flt3 fusion proteins", "Signaling by flt3 itd and tkd mutants", "Signaling by gpcr", "Signaling by hedgehog", "Signaling by hippo", "Signaling by insulin receptor", "Signaling by interleukins", "Signaling by kit in disease", "Signaling by leptin", "Signaling by mapk mutants", "Signaling by met", "Signaling by moderate kinase activity braf mutants", "Signaling by mras complex mutants", "Signaling by mst1", "Signaling by nodal", "Signaling by notch", "Signaling by notch1", "Signaling by notch1 pest domain mutants in cancer", "Signaling by notch2", "Signaling by notch3", "Signaling by notch4", "Signaling by ntrk2 trkb", "Signaling by ntrk3 trkc", "Signaling by ntrks", "Signaling by nuclear receptors", "Signaling by pdgf", "Signaling by pdgfr in disease", "Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants", "Signaling by ptk6", "Signaling by receptor tyrosine kinases", "Signaling by retinoic acid", "Signaling by rho gtpases miro gtpases and rhobtb3", "Signaling by robo receptors", "Signaling by scf kit", "Signaling by tgf beta receptor complex", "Signaling by tgfb family members", "Signaling by the b cell receptor bcr", "Signaling by type 1 insulin like growth factor 1 receptor igf1r", "Signaling by vegf", "Signaling by wnt", "Signaling by wnt in cancer", "Signalling to erks", "Signalling to ras", "Sirt1 negatively regulates rrna expression", "Slbp dependent processing of replication dependent histone pre mrnas", "Slc mediated transmembrane transport", "Slc transporter disorders", "Smac xiap regulated apoptotic response", "Smad2 smad3 smad4 heterotrimer regulates transcription", "Small interfering rna sirna biogenesis", "Smooth muscle contraction", "Snrnp assembly", "Sodium calcium exchangers", "Sos mediated signalling", "Sphingolipid de novo biosynthesis", "Sphingolipid metabolism", "Spry regulation of fgf signaling", "Srp dependent cotranslational protein targeting to membrane", "Stabilization of p53", "Stat3 nuclear events downstream of alk signaling", "Stat5 activation", "Stat5 activation downstream of flt3 itd mutants", "Stimuli sensing channels", "Sting mediated induction of host immune responses", "Striated muscle contraction", "Sulfide oxidation to sulfate", "Sulfur amino acid metabolism", "Sumo is conjugated to e1 uba2 sae1", "Sumo is transferred from e1 to e2 ube2i ubc9", "Sumoylation", "Sumoylation of chromatin organization proteins", "Sumoylation of dna damage response and repair proteins", "Sumoylation of dna methylation proteins", "Sumoylation of dna replication proteins", "Sumoylation of immune response proteins", "Sumoylation of rna binding proteins", "Sumoylation of sumoylation proteins", "Sumoylation of transcription cofactors", "Sumoylation of transcription factors", "Sumoylation of ubiquitinylation proteins", "Suppression of apoptosis", "Suppression of phagosomal maturation", "Surfactant metabolism", "Switching of origins to a post replicative state", "Synaptic adhesion like molecules", "Syndecan interactions", "Synthesis of 5 eicosatetraenoic acids", "Synthesis of active ubiquitin roles of e1 and e2 enzymes", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol", "Synthesis of diphthamide eef2", "Synthesis of dna", "Synthesis of dolichyl phosphate", "Synthesis of gdp mannose", "Synthesis of glycosylphosphatidylinositol gpi", "Synthesis of ip2 ip and ins in the cytosol", "Synthesis of ip3 and ip4 in the cytosol", "Synthesis of ketone bodies", "Synthesis of leukotrienes lt and eoxins ex", "Synthesis of lipoxins lx", "Synthesis of pa", "Synthesis of pc", "Synthesis of pe", "Synthesis of pg", "Synthesis of pi", "Synthesis of pips at the early endosome membrane", "Synthesis of pips at the er membrane", "Synthesis of pips at the golgi membrane", "Synthesis of pips at the late endosome membrane", "Synthesis of pips at the plasma membrane", "Synthesis of prostaglandins pg and thromboxanes tx", "Synthesis of pyrophosphates in the cytosol", "Synthesis of substrates in n glycan biosythesis", "Synthesis of udp n acetyl glucosamine", "Synthesis of very long chain fatty acyl coas", "Synthesis of wybutosine at g37 of trna phe", "Synthesis secretion and deacylation of ghrelin", "Synthesis secretion and inactivation of glucagon like peptide 1 glp 1", "Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip", "Tak1 activates nfkb by phosphorylation and activation of ikks complex", "Tbc rabgaps", "Tcf dependent signaling in response to wnt", "Tcr signaling", "Telomere c strand lagging strand synthesis", "Telomere c strand synthesis initiation", "Telomere extension by telomerase", "Telomere maintenance", "Termination of o glycan biosynthesis", "Termination of translesion dna synthesis", "Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation", "Tfap2 ap 2 family regulates transcription of growth factors and their receptors", "Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation", "Tgf beta receptor signaling activates smads", "Tgf beta receptor signaling in emt epithelial to mesenchymal transition", "The activation of arylsulfatases", "The canonical retinoid cycle in rods twilight vision", "The citric acid tca cycle and respiratory electron transport", "The nlrp3 inflammasome", "The phototransduction cascade", "The role of gtse1 in g2 m progression after g2 checkpoint", "The role of nef in hiv 1 replication and disease pathogenesis", "Thrombin signalling through proteinase activated receptors pars", "Thromboxane signalling through tp receptor", "Ticam1 rip1 mediated ikk complex recruitment", "Ticam1 traf6 dependent induction of tak1 complex", "Tie2 signaling", "Tight junction interactions", "Tlr3 mediated ticam1 dependent programmed cell death", "Tnf signaling", "Tnfr1 induced nfkappab signaling pathway", "Tnfr1 induced proapoptotic signaling", "Tnfr1 mediated ceramide production", "Tnfr2 non canonical nf kb pathway", "Toll like receptor 9 tlr9 cascade", "Toll like receptor cascades", "Toll like receptor tlr1 tlr2 cascade", "Tp53 regulates metabolic genes", "Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "Tp53 regulates transcription of caspase activators and caspases", "Tp53 regulates transcription of cell cycle genes", "Tp53 regulates transcription of cell death genes", "Tp53 regulates transcription of death receptors and ligands", "Tp53 regulates transcription of dna repair genes", "Tp53 regulates transcription of genes involved in cytochrome c release", "Tp53 regulates transcription of genes involved in g1 cell cycle arrest", "Tp53 regulates transcription of genes involved in g2 cell cycle arrest", "Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain", "Traf3 dependent irf activation pathway", "Traf6 mediated induction of tak1 complex within tlr4 complex", "Traf6 mediated irf7 activation", "Traf6 mediated irf7 activation in tlr7 8 or 9 signaling", "Traf6 mediated nf kb activation", "Trafficking and processing of endosomal tlr", "Trafficking of ampa receptors", "Trafficking of glur2 containing ampa receptors", "Trafficking of myristoylated proteins to the cilium", "Trans golgi network vesicle budding", "Transcription coupled nucleotide excision repair tc ner", "Transcription of e2f targets under negative control by dream complex", "Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1", "Transcription of the hiv genome", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activity of smad2 smad3 smad4 heterotrimer", "Transcriptional regulation by e2f6", "Transcriptional regulation by mecp2", "Transcriptional regulation by runx1", "Transcriptional regulation by runx2", "Transcriptional regulation by runx3", "Transcriptional regulation by small rnas", "Transcriptional regulation by the ap 2 tfap2 family of transcription factors", "Transcriptional regulation by tp53", "Transcriptional regulation by ventx", "Transcriptional regulation of granulopoiesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation of white adipocyte differentiation", "Transferrin endocytosis and recycling", "Translation", "Translation of replicase and assembly of the replication transcription complex", "Translation of sars cov 1 structural proteins", "Translation of sars cov 2 structural proteins", "Translesion synthesis by polh", "Translesion synthesis by polk", "Translesion synthesis by y family dna polymerases bypasses lesions on dna template", "Translocation of slc2a4 glut4 to the plasma membrane", "Transmission across chemical synapses", "Transport and synthesis of paps", "Transport of bile salts and organic acids metal ions and amine compounds", "Transport of connexons to the plasma membrane", "Transport of fatty acids", "Transport of inorganic cations anions and amino acids oligopeptides", "Transport of mature mrnas derived from intronless transcripts", "Transport of mature transcript to cytoplasm", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "Transport of nucleotide sugars", "Transport of small molecules", "Transport of the slbp dependant mature mrna", "Transport of vitamins nucleosides and related molecules", "Transport to the golgi and subsequent modification", "Trif mediated programmed cell death", "Triglyceride catabolism", "Triglyceride metabolism", "Tristetraprolin ttp zfp36 binds and destabilizes mrna", "Trna aminoacylation", "Trna modification in the mitochondrion", "Trna modification in the nucleus and cytosol", "Trna processing", "Trna processing in the mitochondrion", "Trna processing in the nucleus", "Trp channels", "Tryptophan catabolism", "Type i hemidesmosome assembly", "Tyrosine catabolism", "Tysnd1 cleaves peroxisomal proteins", "Ub specific processing proteases", "Ubiquinol biosynthesis", "Uch proteinases", "Unblocking of nmda receptors glutamate binding and activation", "Unfolded protein response upr", "Unwinding of dna", "Uptake and actions of bacterial toxins", "Uptake and function of anthrax toxins", "Uptake and function of diphtheria toxin", "Urea cycle", "Vasopressin regulates renal water homeostasis via aquaporins", "Vegfr2 mediated cell proliferation", "Vegfr2 mediated vascular permeability", "Vesicle mediated transport", "Viral messenger rna synthesis", "Visual phototransduction", "Vitamin b1 thiamin metabolism", "Vitamin b2 riboflavin metabolism", "Vitamin b5 pantothenate metabolism", "Vitamin c ascorbate metabolism", "Vitamin d calciferol metabolism", "Vldl assembly", "Vldlr internalisation and degradation", "Vxpx cargo targeting to cilium", "Wax and plasmalogen biosynthesis", "Wnt ligand biogenesis and trafficking", "Wnt mediated activation of dvl", "Wnt5a dependent internalization of fzd2 fzd5 and ror2", "Wnt5a dependent internalization of fzd4", "Zbp1 dai mediated induction of type i ifns", "Zinc efflux and compartmentalization by the slc30 family", "Zinc influx into cells by the slc39 gene family", "Zinc transporters"], "available_proteins": ["AAAS", "AAMP", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGFG1", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AKAP1", "AKAP12", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "AKT2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALG9", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKLE2", "ANLN", "ANO10", "ANO6", "ANXA1", "ANXA2", "ANXA6", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3M1", "APC", "APEH", "APEX1", "APOO", "APOOL", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARG2", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID4B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6", "ARL6IP5", "ARMCX3", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC1", "ASCC2", "ASCC3", "ASF1A", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD2", "ATAD3B", "ATG13", "ATG3", "ATG4B", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATP7B", "AURKA", "B3GALT6", "B4GAT1", "BABAM2", "BAG2", "BAG5", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1B", "BCAP31", "BCAS2", "BCKDK", "BCL10", "BCS1L", "BICD2", "BIRC6", "BLMH", "BLOC1S1", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BRAP", "BRCA1", "BRD1", "BRD2", "BRD4", "BRD7", "BSG", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "C19orf70", "C1QBP", "C1orf35", "C2CD5", "CAB39", "CAD", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCDC22", "CCDC8", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CCZ1B", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP2", "CDK7", "CDK9", "CDKAL1", "CDS2", "CEP290", "CETN2", "CFL1", "CHAC2", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHEK2", "CHERP", "CHID1", "CHKA", "CHMP1A", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHP1", "CHST14", "CIAPIN1", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP2", "CLCN3", "CLINT1", "CLNS1A", "CLTA", "CLTB", "CLTC", "CMAS", "CMPK1", "CNDP2", "CNN2", "CNOT1", "CNOT3", "CNOT7", "CNOT9", "COASY", "COG3", "COG4", "COG7", "COG8", "COLEC12", "COLGALT1", "COMMD1", "COMMD4", "COMMD7", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "COTL1", "COX11", "COX14", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2L", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRK", "CRKL", "CRNKL1", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK1E", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUL7", "CXADR", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DAGLB", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCD", "DCP1B", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D5", "DCXR", "DDAH2", "DDB1", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX52", "DDX56", "DDX6", "DEGS1", "DEK", "DERL1", "DFFA", "DGCR8", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX36", "DHX37", "DHX38", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJB11", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK1", "DOCK7", "DOHH", "DOLPP1", "DPH2", "DPM1", "DPYSL2", "DR1", "DSG2", "DSP", "DST", "DTYMK", "DUS2", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFHD2", "EFTUD2", "EHD1", "EHHADH", "EHMT1", "EHMT2", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC3", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHA7", "EPHX1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERCC3", "ERCC6L", "ERLIN1", "ERLIN2", "ERO1A", "ESD", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EXO1", "EXOC2", "EXOC4", "EXOC5", "EXOC6", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FADS2", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM3C", "FAM49B", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP2", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FBXO22", "FBXO7", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP14", "FKBP4", "FKBP5", "FKBP8", "FLAD1", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FNBP1", "FNTA", "FNTB", "FOXK1", "FOXK2", "FSCN1", "FTL", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FUS", "FXR1", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLC", "GCN1", "GDAP1", "GDE1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GGH", "GGPS1", "GHDC", "GINS1", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLTP", "GLUD1", "GM2A", "GMPPA", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAO1", "GNL3", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GORASP2", "GOSR1", "GOSR2", "GOT1", "GOT2", "GPAT4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2H4", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP3", "GUSB", "GYG1", "GYS1", "H1F0", "H2AFX", "H4C1*", "HACD2", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAT1", "HAUS1", "HAUS2", "HAUS4", "HAUS5", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HEBP1", "HECTD1", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMGCR", "HMGCS1", "HMGN1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTT", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IFT88", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IKBKG", "ILF2", "IMMT", "IMP3", "IMPAD1", "IMPDH1", "IMPDH2", "INCENP", "INPP4A", "INTS1", "INTS10", "INTS11", "INTS12", "INTS14", "INTS3", "INTS8", "IPO5", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "IRS4", "ISCU", "IST1", "ISYNA1", "ITGAV", "ITGB1", "ITPA", "IVD", "IWS1", "JUP", "KARS", "KAT7", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0391", "KIF11", "KIF14", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIN", "KLC1", "KLC4", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LARS", "LARS2", "LAS1L", "LBR", "LCLAT1", "LCMT2", "LDB1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LNPEP", "LPCAT1", "LRPPRC", "LRRC1", "LRRC8C", "LSM2", "LSM4", "LSM6", "LSS", "LTA4H", "LTV1", "LYPLA1", "LYPLA2", "LZTFL1", "M6PR", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAN1A1", "MAN1A2", "MAN2A1", "MANF", "MAP2K1", "MAP2K2", "MAP3K7", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MARC1", "MARS", "MAT2A", "MAT2B", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED16", "MED23", "MED24", "MED4", "METAP2", "METTL1", "METTL3", "MFAP1", "MFN2", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINPP1", "MIPEP", "MLEC", "MMAB", "MMGT1", "MMS19", "MOGS", "MORC2", "MORF4L1", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPRIP", "MPST", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL27", "MRPL3", "MRPL33", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS17", "MRPS2", "MRPS21", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSI1", "MSI2", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTOR", "MTR", "MTX1", "MTX2", "MUT", "MVD", "MYBBP1A", "MYDGF", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1C", "MYO6", "NADK2", "NAE1", "NAGLU", "NAMPT", "NANS", "NAPA", "NARS", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCKAP1", "NCKIPSD", "NCL", "NCOR1", "NCSTN", "ND5", "NDC1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB11", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS5", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEDD4L", "NEFL", "NEK9", "NELFB", "NELFCD", "NELFE", "NF1", "NFRKB", "NFS1", "NHLRC2", "NHP2", "NIP7", "NIPBL", "NIPSNAP2", "NISCH", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOC2L", "NOC4L", "NOL11", "NOL6", "NOL9", "NOP10", "NOP14", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPHP3", "NPLOC4", "NPM1", "NRBP1", "NRP1", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSMCE3", "NSUN2", "NT5C2", "NT5C3A", "NT5C3B", "NUB1", "NUBP2", "NUCB1", "NUDC", "NUDT1", "NUDT19", "NUDT21", "NUDT5", "NUDT9", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OMA1", "OPA1", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "OXCT1", "P3H1", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK2", "PAK4", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARL", "PARN", "PARP1", "PARP2", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCM1", "PCMT1", "PCNA", "PDAP1", "PDCD11", "PDCD6", "PDCD6IP", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA6", "PDK1", "PDK3", "PDLIM5", "PDS5A", "PDS5B", "PDSS2", "PDXK", "PEBP1", "PECR", "PELP1", "PES1", "PEX1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PICALM", "PIGG", "PIGK", "PIGS", "PIGT", "PIK3C2A", "PIK3R2", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PMPCA", "PMPCB", "PMVK", "PNO1", "PNP", "PNPLA6", "POFUT1", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR2L", "POLR3A", "POLR3C", "POLR3E", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPFIA1", "PPIB", "PPID", "PPIH", "PPIL1", "PPIL4", "PPM1F", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4C", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF6", "PRPF8", "PRPS1", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSPH", "PTBP1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUF60", "PUM1", "PUS1", "PUS7", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RABGEF1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RALA", "RALGAPB", "RAN", "RANBP1", "RANBP2", "RANGAP1", "RAP1GDS1", "RAP2B", "RAPGEF2", "RARS", "RASA1", "RBBP5", "RBBP6", "RBM14", "RBM17", "RBM22", "RBM28", "RBM4", "RBM5", "RBM8A", "RBMX", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RDH11", "RDH13", "RDH14", "RDX", "REPS1", "RETSAT", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT2", "RIDA", "RIF1", "RINT1", "RIOK2", "RIPK1", "RNASET2", "RNF2", "RNF20", "RNF40", "RNMT", "RNPS1", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPA3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS27", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP36", "RRP7A", "RRP8", "RRP9", "RSF1", "RSU1", "RTCB", "RTF1", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "SACM1L", "SAE1", "SAFB", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SARNP", "SARS", "SARS2", "SART1", "SC5D", "SCAMP1", "SCAP", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCO2", "SCP2", "SCRIB", "SDCBP", "SDHA", "SDHB", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEH1L", "SEL1L", "SENP3", "SEPT2", "SEPT7", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SGPL1", "SGTA", "SH3GL1", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIN3A", "SIN3B", "SIRT1", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A26", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC2A8", "SLC30A5", "SLC35B2", "SLC38A1", "SLC39A14", "SLC3A2", "SLC44A1", "SLC4A7", "SLC7A1", "SLIT2", "SLK", "SLTM", "SMARCA4", "SMARCA5", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMG5", "SMG8", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX2", "SNX3", "SNX5", "SNX9", "SOAT1", "SOD2", "SORD", "SPAG9", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPDL1", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR3", "SSR4", "SSRP1", "ST3GAL4", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3NL", "STARD7", "STAT1", "STAT3", "STIP1", "STK26", "STK38", "STK4", "STMN1", "STOML2", "STRAP", "STRN", "STT3A", "STUB1", "STX10", "STX18", "STX4", "STX5", "STX6", "STXBP3", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGT1", "SUMF2", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SURF4", "SUZ12", "SYMPK", "SYNE1", "SYNE2", "TAB1", "TACC3", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TARS", "TARS2", "TAX1BP1", "TBC1D10A", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBCA", "TBCB", "TBCD", "TBCE", "TBL3", "TCEA1", "TCP1", "TDP2", "TECR", "TERF2IP", "TEX10", "TEX264", "TFAM", "TFB1M", "TFG", "TFRC", "TGOLN2", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THTPA", "THUMPD1", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM13", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMMDC1", "TJP1", "TJP2", "TK1", "TKFC", "TKT", "TLN1", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM126B", "TMEM87A", "TMF1", "TMLHE", "TMOD3", "TMPO", "TMPO", "TNKS1BP1", "TNPO1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM6", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1A", "TOR1AIP1", "TOR1B", "TP53", "TP53BP1", "TPD52", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPX2", "TRA2B", "TRAM1", "TRAP1", "TRAPPC2L", "TRAPPC3", "TRAPPC5", "TRAPPC8", "TRIM13", "TRIM21", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIO", "TRIP10", "TRIP12", "TRMT10C", "TRMT11", "TRMT6", "TRMU", "TRRAP", "TSC2", "TSFM", "TSG101", "TSNAX", "TSPO", "TSR1", "TSR3", "TTC26", "TTC37", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBG1", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TWNK", "TXLNA", "TXNDC5", "TXNL1", "TXNL4A", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAC1", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBQLN2", "UBR4", "UBTF", "UBXN1", "UBXN7", "UCHL5", "UCK2", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNG", "UPF1", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP28", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VKORC1L1", "VPS25", "VPS26A", "VPS29", "VPS33B", "VPS35", "VPS37B", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WARS2", "WBP11", "WDR1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR4", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WFS1", "WIPI2", "WRAP53", "WTAP", "XAB2", "XPA", "XPO1", "XPO5", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YIF1A", "YKT6", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H11A", "ZC3HAV1", "ZC3HC1", "ZFYVE16", "ZMYM2", "ZNF512B", "ZNF638", "ZW10", "ZWILCH", "ZZZ3"], "leading_proteins": ["AAAS", "AATF", "ABCB1", "ABCB7", "ABHD10", "ACAT2", "ACOX1", "ACOX3", "ACP6", "ACSL1", "ACSL3", "ADD1", "AFG3L2", "AGK", "AGPAT5", "AGPS", "AKT2", "ALDH3A2", "ALG1", "ALG12", "ALG9", "AMOT", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANKLE2", "ANO10", "ANO6", "APOO", "APOOL", "ARFGAP1", "ARHGEF7", "ARL6IP5", "ARMCX3", "ASAH1", "ASNA1", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5B", "ATP5F1", "ATP5I", "ATP5L", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V1E1", "ATP7A", "ATP7B", "B3GALT6", "B4GAT1", "BAG6", "BAIAP2", "BCAP31", "BCS1L", "BICD2", "BLOC1S1", "BNIP1", "BSG", "BUB1B", "C19orf70", "CALU", "CANX", "CASK", "CBFB", "CCNB1", "CD47", "CDC27", "CDC37", "CDK1", "CDK4", "CDS2", "CETN2", "CHCHD3", "CHKA", "CHMP1A", "CHMP2B", "CHMP3", "CHST14", "CKAP4", "CLCN3", "COG3", "COG7", "COMT", "COPS4", "COPS8", "COX11", "COX14", "COX2", "COX4I1", "COX5A", "COX6C", "CPD", "CPNE3", "CPT1A", "CPT2", "CRK", "CRTAP", "CTNNB1", "CTNND1", "CTSA", "CTSC", "CUL5", "CXADR", "CYB5B", "CYB5R3", "CYP51A1", "DAG1", "DAGLB", "DCTN2", "DCTN3", "DDRGK1", "DDX41", "DERL1", "DHCR24", "DHFR", "DIABLO", "DLD", "DNAJC11", "DNAJC3", "DOCK1", "DOLPP1", "ECE1", "ECH1", "ECSIT", "ELMO2", "EMD", "ENDOD1", "EPB41L3", "EPHX1", "EPS15", "ERLIN1", "ERLIN2", "ERO1A", "ETFDH", "EXOSC8", "FAF2", "FAM3C", "FAR1", "FDFT1", "FECH", "FGFR1OP", "FKBP14", "FKBP4", "FLOT1", "FLOT2", "FNBP1", "FNTA", "FTL", "FUCA1", "FUCA2", "GALNT1", "GALNT2", "GATAD2B", "GBA", "GDE1", "GGCX", "GGPS1", "GINS2", "GLA", "GLB1", "GLG1", "GLTP", "GM2A", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNS", "GOLGA5", "GOLGB1", "GOSR1", "GPAT4", "GPD2", "GPX8", "GRB2", "GSK3A", "GSTO1", "GUSB", "GYS1", "H2AFX", "HACD3", "HAUS1", "HAUS4", "HAUS5", "HEXA", "HGS", "HK1", "HLA-A", "HLA-B", "HLA-C", "HM13", "HMGB1", "HMGCR", "HMOX1", "HMOX2", "HNRNPC", "HNRNPK", "HS2ST1", "HSD17B12", "ICMT", "IFT88", "IGF2BP1", "IGF2R", "IKBKG", "IMMT", "IMPAD1", "INPP4A", "ITGAV", "ITGB1", "KDELR1", "KDSR", "KHSRP", "KIF14", "KIF3A", "KLC4", "KPNA2", "KTN1", "L2HGDH", "LAMP2", "LAMTOR1", "LBR", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIPA", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LNPEP", "LPCAT1", "LRRC8C", "LTA4H", "M6PR", "MAD2L1", "MAGT1", "MAIP1", "MAN1A2", "MAN2A1", "MAPK1", "MAPK14", "MAPK3", "MAVS", "MBOAT7", "MCL1", "MCM6", "MCU", "MED4", "MFAP1", "MFN2", "MIA2", "MIA3", "MICU1", "MICU2", "MMAB", "MMGT1", "MOSPD2", "MOV10", "MPP2", "MSMO1", "MTCH1", "MTR", "MTX1", "MTX2", "NAGLU", "NCSTN", "NDC1", "NDUFA11", "NDUFA13", "NDUFB10", "NDUFB11", "NDUFB4", "NDUFB8", "NDUFB9", "NEFL", "NNT", "NPC1", "NUCB1", "NUDT19", "NUP107", "NUP210", "NUP35", "NUP37", "NUP54", "NUP62", "NUP88", "NUP93", "OCLN", "OLA1", "P3H1", "P4HA1", "PAK2", "PAK4", "PARL", "PCBD1", "PDE6D", "PDHX", "PECR", "PEX14", "PEX19", "PFDN6", "PHB", "PHB2", "PIGG", "PIGK", "PIGS", "PIK3R2", "PIP4K2C", "PISD", "PITRM1", 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phosphorylation 11 33 2.586896041824243 0.0096844805713574 10.094660194174756 30.308252427184467 0.4493106572238387 0.4094278581483465 4.631390429635194 3.3340884045985604 1.35936739882113 0.3321380007425058 2.7869167477218715e-05 0.0247821522094747 0.0015259573241502 0.0002314913891327 3.11780669585079e-05 +Kennedy pathway from sphingolipids 3 5 2.48148481155925 0.0130836286091398 1.8349514563106797 4.538834951456311 1.005685357170638 0.2842758763214292 1.1414272055653287 1.0616650240280194 1.1079123437614409 0.2814205551839854 0.0017074381782845 1.0 1.0 0.0041470760753771 0.003721367796782 +Ferroptosis 12 24 2.469221728399054 0.0135407287659401 6.247572815533981 23.589805825242717 0.9586016481897424 0.3324276931898122 2.8577723913591164 2.1450310521583007 1.2134257594151 0.3161491716459103 0.0035351919501872 0.001740287381965 0.0128487417044244 0.0074685925596388 0.0029392451780606 +Sphingolipid metabolism in senescence 4 10 2.454974720707213 0.0140894495930945 4.349514563106796 11.679611650485436 1.1898351622318797 0.2087194733713789 1.8732078185138223 1.4259290429724831 1.4063103725171229 0.2533781048666968 0.0114287110152524 0.1029565435856987 0.1993869387044997 0.1053546389470493 0.0042957165481444 +Ccl18 signaling pathway 4 11 2.357200099331466 0.0184133218054838 3.145631067961165 9.468446601941748 0.7120304545820841 0.4102816521154631 1.5448490483978532 1.266243781864224 0.905865942202216 0.3015635802046986 0.0020770051311059 1.0 0.2070995190727305 0.0193169154759243 0.0052134507581354 +Intracellular trafficking proteins involved in cmt neuropathy 7 11 2.302295108506199 0.0213185354940714 2.5825242718446604 9.4126213592233 0.5651067696606721 0.3956590939588119 1.7010805922853014 1.920668351091252 1.0307289556591432 0.2847016918534578 0.0097364536063123 0.0987043131013681 0.191600110602388 0.0152248647419399 0.0200033311952484 +Mitochondrial immune response to sarscov2 4 8 2.2592931673125105 0.0238651546590964 3.674757281553398 8.939320388349515 0.2609941241524592 0.4397421433921452 2.181351609438601 1.0787927108046689 1.131627442692276 0.3196830596507893 0.0728326355906942 1.0 0.2147385524083838 0.0215683584236732 0.1188827437046941 +Glycosaminoglycan degradation 4 6 2.2218195037013286 0.026295506106708 3.407766990291262 5.864077669902913 0.1350713234786387 0.1703873780123549 1.3379225542760151 0.7043353086258667 1.932540087143412 0.2532951180616937 5.712917963828504e-05 1.0 1.0 0.032628233248221 0.0001575214550341 +Sphingolipid metabolism overview 3 6 2.186676056849438 0.0287661806972048 4.0 7.951456310679611 1.305604070038762 0.1692072490812911 2.0060587839493125 1.5113078035984122 1.4254327231792938 0.2283290755268721 0.0270625432516923 0.0771453392642774 0.1515272625734178 0.0621585272883563 0.0078812527225172 +Sphingolipid metabolism integrated pathway 3 6 2.186676056849438 0.0287661806972048 4.058252427184466 8.101941747572816 1.3056837288293504 0.1731905617886817 2.1182299017960826 1.603786816240382 1.4154175704443392 0.233855234687812 0.0364081996833034 0.0858288536093336 0.1677870330809631 0.0757571260003459 0.0118865434534573 +Degradation pathway of sphingolipids including diseases 5 6 2.1609468904543543 0.030699442184493 3.645631067961165 6.432038834951456 0.0687547082162972 0.1728701573933007 1.3368036576958324 0.5554170290527195 1.9109030412897592 0.2451148181788838 0.0002513170710231 1.0 0.0832836732680532 0.0010464818333657 2.8311070051942505e-05 +Oxidation by cytochrome p450 3 6 2.146919597574959 0.0317996831311278 2.3179611650485437 5.422330097087379 1.262256455948566 0.1900711291682963 1.161003800051733 0.6764315332620536 1.214909583878196 0.2447393771863318 0.0012582535978488 0.0016377422378922 0.0066572828402184 0.0033170374819039 0.0027630263410089 +Statin inhibition of cholesterol production 3 5 2.0901097163450117 0.0366079450639362 2.0315533980582523 5.029126213592233 1.044092701346018 0.2144191485801186 1.2890406286437517 1.2084356467042294 1.2621579412510306 0.2395890160394713 0.0157995115126844 1.0 1.0 0.0041470760753771 0.003721367796782 +Endothelin pathways 2 8 2.0818151937314737 0.0373593533961544 1.9320388349514563 7.987864077669903 0.7329149217629526 0.3753320686971037 1.368949252800948 0.99139418402927 0.9285569766983348 0.277149256001259 0.0315532322883059 1.0 0.0126574737404708 0.0086586519898169 0.0539281835546241 +Cholesterol metabolism with bloch and kandutschrussell pathways 8 25 2.081038527721426 0.0374303796978807 7.092233009708738 23.070388349514563 1.3045876527781233 0.2885598195159411 3.1892169450204397 2.132138915277104 1.1515799969949023 0.3088028425519339 0.0005035364296941 1.0 1.0 0.0002303056568621 5.121649611699266e-05 +Familial partial lipodystrophy fpld 6 8 1.982854391096066 0.0473836964462957 2.7354368932038833 7.351941747572815 1.0487704575374006 0.2220749325398317 1.64741826657551 0.7567951823729889 1.2080189526980365 0.2461617416466816 0.1983785715691609 1.0 0.1837383274168749 0.0901924811619011 0.0790607116166092 diff --git a/msigdb_wp/metrics.json b/msigdb_wp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..5f8f8a632fe961f9d7c8b48d5b41b9afc4c584b0 --- /dev/null +++ b/msigdb_wp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3120, + "annotations_size": 596, + "title": "Average number of proteins per term", + "value": 10.781879194630873 +} \ No newline at end of file diff --git a/msigdb_wp/paths.json b/msigdb_wp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..c9562509e280ba5734db4599aff1d7f7b106e9af --- /dev/null +++ b/msigdb_wp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_wp/fragment/C390/C390_val_log2fc"} \ No newline at end of file diff --git a/msigdb_wp/result.tsv b/msigdb_wp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..b29ffc7d8e6ded646019bfe0a83e574d5e6f8312 --- /dev/null +++ b/msigdb_wp/result.tsv @@ -0,0 +1,114 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Electron transport chain oxphos system in mitochondria 0.6299745316457389 3.8368049285376977 0.0001246454028072 0.0716006366463556 0.0371443300365491 54 Q9UDW1,O75880,O14949,Q7KZN9,O75964,P13073,P14406,P24539,P14927,O95169,P21912,O96000,P00846,P20674,P22695,Q9Y6M9,P56385,P00403,O95168 19 +Nonalcoholic fatty liver disease 0.5715201480308567 3.2098847362463916 0.0013278820839381 0.54703645998628 0.113059674575309 51 P13073,P14406,P20674,O95169,Q96GC9,Q86Y39,P22695,Q9P0J0,Q9Y6M9,Q9UDW1,P21912,O96000,O14949,P00403 14 +Mitochondrial complex iv assembly 0.7970796572125457 2.963683991669388 0.0030398027580069 0.8370776669870535 0.1878700119576529 13 P13073,P20674,P14406,Q9Y6N1,Q9Y2R0,Q96I36,O43819,Q7KZN9,P00403 9 +Mitochondrial complex i assembly model oxphos system 0.6055438886913772 2.8135418968195745 0.0048999000507912 0.9464702966376556 0.204812486767911 28 Q9BQ95,O95169,Q9BUB7,Q9P0J0,Q96CU9,Q9Y6M9,O96000,Q9NPL8,Q9NX14,O95168,Q8IUX1 11 +Mitochondrial complex iii assembly 0.8289672444502935 2.806016179918169 0.0050158173675312 0.9500608255851334 0.204812486767911 10 P14927,Q9Y276,P22695,Q9UDW1,O14949 5 +Oxidative phosphorylation 0.5463290968526939 2.586896041824243 0.0096844805713574 0.9969726915697442 0.204812486767911 33 P24539,O95169,Q86Y39,P06576,Q9Y6M9,O96000,O95168,P56385,P00846,O75964,Q15904 11 +Kennedy pathway from sphingolipids 0.912555436577804 2.48148481155925 0.0130836286091398 0.9996099766896052 0.204812486767911 5 Q9BVG9,O95470,P35790 3 +Ferroptosis 0.5832822630551003 2.469221728399054 0.0135407287659401 0.999704077019426 0.204812486767911 24 P04035,P02792,P08195,P16435,P45880,Q15043,Q15758,Q9NZ45,P09601,Q9Y277,P02786,P37268 12 +Sphingolipid metabolism in senescence 0.7583918310901185 2.454974720707213 0.0140894495930945 0.9997875980961844 0.204812486767911 10 O15269,P04062,P16278,Q13510 4 +Ccl18 signaling pathway 0.7169500082871361 2.357200099331466 0.0184133218054838 0.9999845304114536 0.2275606687500745 11 P08670,P07196,P00403,Q86UE4 4 +Intracellular trafficking proteins involved in cmt neuropathy 0.7066998327745971 2.302295108506199 0.0213185354940714 0.9999973560547484 0.2405180941729724 11 Q9NR77,Q8TB36,P07196,O95140,P04792,Q15907,Q9UI14 7 +Mitochondrial immune response to sarscov2 0.7620072335799413 2.2592931673125105 0.0238651546590964 0.9999994404351328 0.2495374066109031 8 Q9BQ95,Q99623,Q9Y6M9,Q9Y276 4 +Glycosaminoglycan degradation 0.8199280837256331 2.2218195037013286 0.026295506106708 0.9999998733526996 0.2542951164920201 6 P06865,P16278,P15586,P54802 4 +Sphingolipid metabolism overview 0.8120824518361381 2.186676056849438 0.0287661806972048 0.9999999721398952 0.2542951164920201 6 O15269,O95470,Q13510 3 +Sphingolipid metabolism integrated pathway 0.8120824518361381 2.186676056849438 0.0287661806972048 0.9999999721398952 0.2542951164920201 6 O15269,O95470,Q13510 3 +Degradation pathway of sphingolipids including diseases 0.8063583815028732 2.1609468904543543 0.030699442184493 0.999999991503428 0.2637240536326816 6 P06280,P17900,O43681,P16278,P06865 5 +Oxidation by cytochrome p450 0.8032446790009128 2.146919597574959 0.0317996831311278 0.999999995682112 0.2644595387614276 6 Q6UW02,O43169,Q16850 3 +Proteoglycan biosynthesis 0.90982028241334 2.145058972516934 0.031948132199367 0.9999999960592232 0.2644595387614276 4 Q8TB61,Q8NCH0,Q9NX62 3 +Statin inhibition of cholesterol production 0.821200358634524 2.0901097163450113 0.0366079450639362 0.9999999997778616 0.2720549548772797 5 P37268,Q8WTV0,Q14534 3 +Endothelin pathways 0.7258285779342764 2.0818151937314737 0.0373593533961544 0.9999999998604724 0.2720549548772797 8 P42892,P00403 2 +Cholesterol metabolism with bloch and kandutschrussell pathways 0.5262619015208952 2.081038527721426 0.0374303796978807 0.9999999998664753 0.2720549548772797 25 Q14534,Q16850,Q15800,O95749,Q15392,Q9BWD1,P37268,O75845 8 +Familial partial lipodystrophy fpld 0.7059731463632821 1.982854391096066 0.0473836964462957 0.9999999999997276 0.3103371767251894 8 P20700,O60725,Q03252,P02545,O75844,P49354 6 +Acquired partial lipodystrophy barraquersimons syndrome 0.7865168539325855 1.937061446270004 0.0527378326732197 0.9999999999999906 0.3416494377525975 5 O60725,P20700,P02545,Q03252 4 +Copper homeostasis 0.6749274532827882 1.918477696313592 0.0550504675501535 0.9999999999999978 0.3475820781272767 9 Q04656,Q9Y6N1,O75880,P35670,O43819 5 +Cholesterol biosynthesis with skeletal dysplasias 0.7402923939090129 1.858616160236503 0.0630815648257752 1.0 0.3709454242912344 6 Q15392,Q15738,Q16850,O75845 4 +Sphingolipid pathway 0.7034242019307837 1.7983060226621066 0.0721285258642745 1.0 0.4017626300477348 7 O15269,O95470,Q13510,P04062 4 +Overlap between signal transduction pathways contributing to lmna laminopathies 0.551284080797398 1.7870424630907027 0.0739306257293428 1.0 0.4024382945751545 16 O60725,Q9Y2U8,P02545,P42167,P55209,O75844,P50402,P49354,P25054 9 +Photodynamic therapyinduced nfe2l2 nrf2 survival signaling 0.8181020316578906 1.7639716507599308 0.0777367522452436 1.0 0.4136705744479038 4 P09601 1 +Metapathway biotransformation phase i and ii 0.4921429943316818 1.7232769096579548 0.0848384613019597 1.0 0.4384304635450994 22 Q8NCH0,Q6UW02,Q7LGA3,P21964 4 +Mitochondrial long chain fatty acid betaoxidation 0.5612089143013775 1.7000665882957136 0.08911840109044 1.0 0.4426213920825187 14 O43772,P23786,P50416 3 +S1p receptor signal transduction 0.6479202612188045 1.6873363535627977 0.091538694509657 1.0 0.4471890321947178 8 P04899,P31751,P27361,Q13510 4 +Glycosylation and related congenital defects 0.6395221482239484 1.6438563185143134 0.1002058848778455 1.0 0.4726124711856482 8 Q9BV10,Q9H6U8,Q9BT22 3 +1q211 copy number variation syndrome 0.6061183992091733 1.6437332554652329 0.1002313134852432 1.0 0.4726124711856482 10 Q9NPH0 1 +Progeriaassociated lipodystrophy 0.5924353008257021 1.5673054600256475 0.1170433097576479 1.0 0.5129250927614574 10 P20700,O60725,Q03252,P02545,O75844 5 +Vitamin d receptor pathway 0.5564134166814352 1.4558280172261613 0.1454401685819617 1.0 0.5665512449336549 11 P08183,Q96KA5,P20020,Q5VV42 4 +Cholesterol biosynthesis pathway 0.5207541669892761 1.4426997791311924 0.1491050614947968 1.0 0.5748389839890989 14 P04035,Q14534,Q15738,Q16850,Q15800,P14324,P37268,O75845 8 +Nephrotic syndrome 0.5321863026050766 1.441311444067627 0.1494967156347488 1.0 0.5748389839890989 13 O75844,Q14108 2 +Amyotrophic lateral sclerosis als 0.58337137036202 1.428602311499524 0.1531185694174826 1.0 0.5812653972791059 9 P07196,Q9BUN8,O96008 3 +Adipogenesis 0.5019471825943727 1.398496014696771 0.161964168597084 1.0 0.598399310109997 15 O75844,Q9NZ45 2 +Allograft rejection 0.5755850048531559 1.3859751571384362 0.1657544894436022 1.0 0.5994506844273038 9 P08183,P10321,P08670 3 +Relationship between inflammation cox2 and egfr 0.7282326615868759 1.3798135368197426 0.1676440635911433 1.0 0.5994506844273038 4 P31751,Q9H7Z7 2 +Striated muscle contraction pathway 0.6576274407199625 1.3495999191075976 0.17714435014389 1.0 0.6064732914318653 5 P08670,P67936,P09493 3 +Metabolism of spingolipids in er and golgi apparatus 0.8719923002887319 1.3356719922535196 0.1816565076915592 1.0 0.6114844405754853 3 O95470,Q10472 2 +Influence of laminopathies on wnt signaling 0.5335326707621764 1.3207663332122497 0.186579288577704 1.0 0.6114844405754853 11 O60725,Q5JTV8,P02545,O75844,P50402,P49354 6 +Cellular proteostasis 0.6419778947232611 1.276807930595658 0.2016700649847322 1.0 0.6359542789994732 5 O15212,Q9UHV9 2 +Vitamin d metabolism 0.8508359857509991 1.2529494047958507 0.210224120354074 1.0 0.6509370477798814 3 P38435 1 +Alzheimers disease and mirna effects 0.3617737433143113 1.2310747043145438 0.2182949253816717 1.0 0.6509370477798814 82 P28074,P49721,P16615,Q13885,Q9BVA1,Q9NQC3,P07437,Q96GC9,P45880,Q92542,Q9Y277,P21796,Q96IX5,O95197,P68371 15 +Glycerolipids and glycerophospholipids 0.6069692199922665 1.2222196203316789 0.2216245861291712 1.0 0.6509370477798814 6 Q9BVG9 1 +Eicosanoid synthesis 0.8527902501603638 1.188578746385987 0.234605475449865 1.0 0.6626770775740262 2 Q9H7Z7 1 +Arrhythmogenic right ventricular cardiomyopathy 0.4803619981754791 1.1805346811442523 0.2377876252710633 1.0 0.6684972861394045 14 P16615,Q14118,P50402,P02545 4 +Regulation of apoptosis by parathyroid hormonerelated protein 0.681200283217136 1.1766739716874832 0.2393256604954818 1.0 0.6696624115272638 4 Q07820 1 +Ketogenesis and ketolysis 0.5694252951624977 1.1302318790477155 0.2583785301503587 1.0 0.6968036378715556 7 P23786 1 +Glycerophospholipid biosynthetic pathway 0.5673063673398836 1.119462751614815 0.2629427730776525 1.0 0.6985428368081307 7 Q86UL3,O95674,O00116 3 +Omega3 omega6 fatty acid synthesis 0.581029252436512 1.095885297003672 0.27312897420425 1.0 0.7017986080893664 6 O15254,P33121,Q15067 3 +Zinc homeostasis 0.8079234235637653 1.0859920612796896 0.2774825045312377 1.0 0.7026097267745854 3 Q8TAD4 1 +Triacylglyceride synthesis 0.639259630261259 0.9961826983646352 0.3191613842861924 1.0 0.7238072902921343 4 O00116 1 +Alzheimers disease 0.340871042156129 0.9950804568021528 0.3196971348555961 1.0 0.7238072902921343 80 P28074,P49721,Q9NSK0,Q9Y277,P21796,P16615,P45880,Q92542,P04350,O95197,P12235,Q9NQC3,P07437,O00459,Q8NE86,P12236,Q13885,Q9BVA1,Q9BUF5,P68371 20 +Apoptosis modulation and signaling 0.4770211740437888 0.9831216000944082 0.3255475945995558 1.0 0.7294224300050198 11 O43464,P27361,Q9NR28,Q9Y3E5,O95831,Q07820 6 +Nanomaterial induced apoptosis 0.6214617089021685 0.9202675067466096 0.3574329847340396 1.0 0.7635485982132172 4 Q9NR28,O95831 2 +Camkk2 pathway 0.4657012533166073 0.9152508312442056 0.3600599650025282 1.0 0.7636859044181737 11 P09601 1 +Inhibition of exosome biogenesis and secretion by manumycin a in crpc cells 0.4800628833476318 0.8571358336587039 0.3913698194289488 1.0 0.801418709521071 9 P27361,P31943,O14964,P62070,P61020 5 +Proximal tubule transport 0.4781342829224588 0.8464714770229683 0.3972897791119001 1.0 0.801418709521071 9 P08183,P05023,P05026,P08195 4 +Apoptosis 0.4772166448651415 0.8413997529074022 0.4001240238627264 1.0 0.801418709521071 9 Q9NR28 1 +Type i collagen synthesis in the context of osteogenesis imperfecta 0.4520783441872882 0.8337288227890317 0.4044338123260516 1.0 0.801418709521071 11 Q5JRA6,O75718,P07237,Q32P28,P13674 5 +Mthfr deficiency 0.4868522280162597 0.8331797851948454 0.4047433415534267 1.0 0.801418709521071 8 P21964 1 +Mrna protein and metabolite inducation pathway by cyclosporin a 0.7597819114817176 0.8162295160362472 0.414368878362974 1.0 0.8090387543374479 2 P08195 1 +Congenital generalized lipodystrophy cgl 0.7588197562540075 0.8125208906153132 0.4164928043780116 1.0 0.8090387543374479 2 P31751 1 +Preimplantation embryo 0.5045432272991083 0.8010402118288722 0.4231083668124824 1.0 0.8121263167115497 7 Q99729,P05023 2 +Pparalpha pathway 0.4797028991132694 0.7951907028751105 0.4265025790783809 1.0 0.8121263167115497 8 P23786 1 +Pkcgamma calcium signaling pathway in ataxia 0.7508017960230979 0.7817750862522995 0.4343467650823864 1.0 0.8131904542668805 2 P23634 1 +Vitamin dsensitive calcium signaling in depression 0.4955618424700792 0.7559184833569205 0.4496980713232128 1.0 0.8205605958685357 7 P20020,P23634 2 +Mevalonate pathway 0.5100694564148948 0.7525448800946203 0.4517234508801171 1.0 0.8205605958685357 6 Q9BWD1,P04035 2 +Phase i biotransformations non p450 0.7102634794170422 0.7182488071588415 0.4726038888773529 1.0 0.8300025520732648 3 Q15165 1 +Tgfbeta signaling in thyroid cells for epithelialmesenchymal transition 0.5723937178106451 0.7152168533371758 0.4744750566689768 1.0 0.8300025520732648 4 P08670 1 +Mevalonate arm of cholesterol biosynthesis pathway 0.4047955520386966 0.5927228111056181 0.5533666727807129 1.0 0.8865767123045831 12 O95749,P37268,Q9BWD1 3 +Interleukin1 induced activation of nfkb 0.6828094932649114 0.5355475994952076 0.5922712521542817 1.0 0.9121283366510384 2 Q13501 1 +Lung fibrosis 0.4565827523768445 0.5042852008533916 0.6140609755652215 1.0 0.9172439635009324 6 P09601 1 +Fatty acid betaoxidation 0.3418145475130728 0.4661927807803894 0.6410775163225673 1.0 0.9404705034493994 19 O43772,P23786,P50416 3 +Ciliopathies 0.3528682187277882 0.463735753383226 0.6428370781379109 1.0 0.9404705034493994 17 Q10713 1 +Nad metabolism 0.4957086046231498 0.4190969219455412 0.6751453001439209 1.0 0.9404705034493994 4 P43490 1 +Fatty acid transporters 0.4894094993581548 0.3968333796183015 0.6914903340953762 1.0 0.94267201914541 4 O95573,P33121,O60488 3 +Nocgmppkg mediated neuroprotection 0.4153488271961952 0.3701993831301609 0.7112339361794155 1.0 0.9461951472386868 7 P07196 1 +Initiation of transcription and translation elongation at the hiv1 ltr 0.4103421272130624 0.3477997344203555 0.727990589128358 1.0 0.9462416481682464 7 Q8IXH7 1 +Ppar signaling pathway 0.3384534575703582 0.3363921403023263 0.7365751756375267 1.0 0.9462416481682464 16 P23786,P50416 2 +Nanoparticle triggered autophagic cell death 0.4103123347804481 0.2647074164953913 0.7912348637106981 1.0 0.9545149152624094 5 Q96GC9 1 +Supression of hmgb1 mediated inflammation by thbd 0.5878768441308476 0.2579507936439993 0.7964448832783502 1.0 0.9545149152624094 2 Q9Y6K9 1 +Primary focal segmental glomerulosclerosis fsgs 0.3169654196531268 0.2565003940910491 0.7975644761756373 1.0 0.9545149152624094 18 P08670,Q14108 2 +Bile acids synthesis and enterohepatic circulation 0.5540583894770704 0.2351465793245917 0.8140949669977318 1.0 0.963378801043856 3 P51114,P27361 2 +Nad metabolism in oncogeneinduced senescence and mitochondrial dysfunctionassociated senescence 0.329177793927639 0.2211412717766985 0.8249824354315078 1.0 0.9636173431349676 14 O43819,P43490 2 +Mammary gland development pathway pregnancy and lactation stage 3 of 4 0.4329362061305628 0.2174776790357253 0.827836100283432 1.0 0.9636173431349676 4 P18031,P06753 2 +Vasopressinregulated water reabsorption 0.311353393461825 0.1933517642639849 0.8466834890813617 1.0 0.9722993439161688 17 Q15907,Q13561 2 +Mapk and nfkb signaling pathways inhibited by yersinia yopj 0.5538806927517598 0.1843783614990333 0.853716643825015 1.0 0.9783916941085306 2 Q9Y6K9 1 +Vitamin b12 disorders 0.5248636509464345 0.1708800940406681 0.8643180490913362 1.0 0.9783916941085306 3 Q99707,Q96EY8 2 +Cannabinoid receptor signaling 0.3730663569638899 0.1677714145929263 0.8667631115592351 1.0 0.9783916941085306 6 Q8NCG7 1 +Thermogenesis 0.2852763149934725 0.1444207609752688 0.8851682237751524 1.0 0.9890432919796354 27 P23786,P50416 2 +Sarscov2 b117 variant antagonises innate immune activation 0.5307889672867152 0.1431696000291778 0.886156238115982 1.0 0.9890432919796354 2 Q7Z434 1 +Purinergic signaling 0.3995507060333821 0.1320864560372428 0.8949159085621856 1.0 0.9913938317900792 4 P04899,P09471,P63096 3 +Tlr4 signaling and tolerance 0.3658216517384852 0.1239831481835839 0.9013286179065588 1.0 0.9925098379567526 5 Q15629 1 +Male infertility 0.2868889068017164 0.1231751205018859 0.90196842648588 1.0 0.9925098379567526 21 P08183,Q15165,Q15645,P50750 4 +Genes related to primary cilium development based on crispr 0.3148387065453583 0.1200376563813972 0.904453318131198 1.0 0.9925098379567526 13 Q10713 1 +Genes controlling nephrogenesis 0.3918485237484063 0.1148679665482727 0.9085497759793087 1.0 0.9935700302452624 4 O94813,P35222,P05556 3 +Praderwilli and angelman syndrome 0.3572119067386784 0.1007025409577075 0.9197865942377644 1.0 1.0 5 Q05086,Q15154 2 +Apoptosis modulation by hsp70 0.4823562909058034 0.0961415186421142 0.9234081769057848 1.0 1.0 3 O95831 1 +Amino acid metabolism pathway excerpt histidine catabolism extension 0.4794740218088438 0.0764291636409041 0.9390776682261022 1.0 1.0 2 P00367 1 +Calcium regulation in cardiac cells 0.2761230001478817 0.056425019693436 0.9550032258691328 1.0 1.0 23 P05026,P16615,P04899,P20020,P23634 5 +Endometrial cancer 0.3000963023957719 0.0501828142222954 0.9599767065613178 1.0 1.0 13 P27361,O00459,P62993,P25054,P31751 5 +Extracellular vesiclemediated signaling in recipient cells 0.3546213093709917 0.0453357131457886 0.9638397217174396 1.0 1.0 4 Q9NWH9,P25054,P35222 3 +Mirnas involved in dna damage response 0.4377806286080761 0.044387922039375 0.964595188977075 1.0 1.0 2 P16104 1 +Robo4 and vegf signaling pathways crosstalk 0.435856318152655 0.0433074698090244 0.965456436764132 1.0 1.0 2 O94813 1 +Mechanoregulation and pathology of yaptaz via hippo and nonhippo mechanisms 0.3311917764214652 0.0427814899605177 0.9658757193506412 1.0 1.0 7 P27348,O96013,P35221,P05556,Q13177,P35222 6 +Sars coronavirus and innate immunity 0.4153303399615112 0.0336037376443806 0.9731931417438906 1.0 1.0 2 Q7Z434 1 +Hepatitis b infection 0.2720251785846441 0.0300517405212248 0.9760257888139195 1.0 1.0 23 Q9Y277 1 +Folate metabolism 0.2884206481947338 0.013829712158585 0.9889658379234708 1.0 1.0 14 Q8WTV0,P00374 2 diff --git a/msigdb_wp/selections.json b/msigdb_wp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..43a3cf68edf70a059d3b264ed784949aadef82d1 --- /dev/null +++ b/msigdb_wp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["15q112 copy number variation syndrome", "15q133 copy number variation syndrome", "16p112 distal deletion syndrome", "16p112 proximal deletion syndrome", "1q211 copy number variation syndrome", "22q112 copy number variation syndrome", "3q29 copy number variation syndrome", "4hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression", "7oxoc and 7betahc pathways", "7q1123 copy number variation syndrome", "Ace inhibitor pathway", "Acetylcholine synthesis", "Acquired partial lipodystrophy barraquersimons syndrome", "Acute viral myocarditis", "Adipogenesis", "Aerobic glycolysis", "Aflatoxin b1 metabolism", "Agerage pathway", "Airway smooth muscle cell contraction", "Alanine and aspartate metabolism", "Allograft rejection", "Alpha 6 beta 4 signaling pathway", "Altered glycosylation of muc1 in tumor microenvironment", "Alternative pathway of fetal androgen synthesis", "Alzheimers disease", "Alzheimers disease and mirna effects", "Amino acid metabolism", "Amino acid metabolism pathway excerpt histidine catabolism extension", "Ampactivated protein kinase ampk signaling", "Amyotrophic lateral sclerosis als", "Androgen receptor signaling pathway", "Angiogenesis", "Angiopoietinlike protein 8 regulatory pathway", "Angiotensin ii receptor type 1 pathway", "Antiviral and antiinflammatory effects of nrf2 on sarscov2 pathway", "Apoptosis", "Apoptosis modulation and signaling", "Apoptosis modulation by hsp70", "Apoptosisrelated network due to altered notch3 in ovarian cancer", "Arachidonate epoxygenase epoxide hydrolase", "Arrhythmogenic right ventricular cardiomyopathy", "Aryl hydrocarbon receptor pathway wp2586", "Aryl hydrocarbon receptor pathway wp2873", "Arylamine metabolism", "Aspirin and mirnas", "Atm signaling in development and disease", "Atm signaling pathway", "Atr signaling", "Autophagy", "Autosomal recessive osteopetrosis pathways", "B cell receptor signaling pathway", "Base excision repair", "Bdnftrkb signaling", "Benzene metabolism", "Benzoapyrene metabolism", "Bile acids synthesis and enterohepatic circulation", "Biogenic amine synthesis", "Biomarkers for pyrimidine metabolism disorders", "Biomarkers for urea cycle disorders", "Biotin metabolism including iems", "Bladder cancer", "Bmp signaling in eyelid development", "Bmp2wnt4foxo1 pathway in primary endometrial stromal cell differentiation", "Brainderived neurotrophic factor bdnf signaling pathway", "Breast cancer pathway", "Burn wound healing", "Calcium regulation in cardiac cells", "Caloric restriction and aging", "Camkk2 pathway", "Cancer immunotherapy by ctla4 blockade", "Cancer immunotherapy by pd1 blockade", "Cannabinoid receptor signaling", "Canonical and noncanonical notch signaling", "Canonical and noncanonical tgfb signaling", "Canonical nfkb pathway", "Cardiac hypertrophic response", "Cardiac progenitor differentiation", "Ccl18 signaling pathway", "Cell cycle", "Cell differentiation expanded index", "Cell differentiation index", "Cell migration and invasion through p75ntr", "Cells and molecules involved in local acute inflammatory response", "Celltype dependent selectivity of cck2r signaling", "Cellular proteostasis", "Cerebral organic acidurias including diseases", "Chemokine signaling pathway", "Cholesterol biosynthesis pathway", "Cholesterol biosynthesis with skeletal dysplasias", "Cholesterol metabolism with bloch and kandutschrussell pathways", "Chromosomal and microsatellite instability in colorectal cancer", "Ciliary landscape", "Ciliopathies", "Circadian rhythm genes", "Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism", "Clear cell renal cell carcinoma pathways", "Codeine and morphine metabolism", "Cohesin complex cornelia de lange syndrome", "Common pathways underlying drug addiction", "Complement and coagulation cascades", "Complement system", "Complement system in neuronal development and plasticity", "Congenital generalized lipodystrophy cgl", "Constitutive androstane receptor pathway", "Control of immune tolerance by vasoactive intestinal peptide", "Copper homeostasis", "Cori cycle", "Corticotropinreleasing hormone signaling pathway", "Cysteine and methionine catabolism", "Cytoplasmic ribosomal proteins", "Cytosine methylation", "Cytosolic dnasensing pathway", "Ddx1 as a regulatory component of the drosha microprocessor", "Degradation pathway of sphingolipids including diseases", "Deregulation of rab and rab effector genes in bladder cancer", "Development of pulmonary dendritic cells and macrophage subsets", "Development of ureteric collection system", "Disorders of folate metabolism and transport", "Disruption of postsynaptic signaling by cnv", "Dna damage response", "Dna damage response only atm dependent", "Dna irdamage and cellular response via atr", "Dna irdouble strand breaks and cellular response via atm", "Dna mismatch repair", "Dna repair pathways full network", "Dna replication", "Dopamine metabolism", "Dopaminergic neurogenesis", "Drug induction of bile acid pathway", "Dual hijack model of vif in hiv infection", "Ebola virus infection in host", "Ebsteinbarr virus lmp1 signaling", "Ectoderm differentiation", "Effect of progerin on genes involved in hutchinsongilford progeria syndrome", "Egfegfr signaling pathway", "Egfr tyrosine kinase inhibitor resistance", "Eicosanoid metabolism via cyclooxygenases cox", "Eicosanoid metabolism via lipooxygenases lox", "Eicosanoid synthesis", "Electron transport chain oxphos system in mitochondria", "Embryonic stem cell pluripotency pathways", "Endochondral ossification", "Endochondral ossification with skeletal dysplasias", "Endoderm differentiation", "Endometrial cancer", "Endoplasmic reticulum stress response in coronavirus infection", "Endothelin pathways", "Energy metabolism", "Envelope proteins and their potential roles in edmd physiopathology", "Epithelial to mesenchymal transition in colorectal cancer", "Epo receptor signaling", "Erbb signaling pathway", "Erk pathway in huntingtons disease", "Estrogen metabolism", "Estrogen receptor pathway", "Estrogen signaling pathway", "Ethanol effects on histone modifications", "Ethanol metabolism production of ros by cyp2e1", "Eukaryotic transcription initiation", "Exerciseinduced circadian regulation", "Exrna mechanism of action and biogenesis", "Extracellular vesiclemediated signaling in recipient cells", "Extracellular vesicles in the crosstalk of cardiac cells", "Factors and pathways affecting insulinlike growth factor igf1akt signaling", "Familial hyperlipidemia type 1", "Familial hyperlipidemia type 3", "Familial hyperlipidemia type 4", "Familial hyperlipidemia type 5", "Familial partial lipodystrophy fpld", "Farnesoid x receptor pathway", "Fas ligand pathway and stress induction of heat shock proteins", "Fatty acid betaoxidation", "Fatty acid biosynthesis", "Fatty acid omegaoxidation", "Fatty acid transporters", "Fbxl10 enhancement of maperk signaling in diffuse large bcell lymphoma", "Ferroptosis", "Fgfr3 signaling in chondrocyte proliferation and terminal differentiation", "Fibrin complement receptor 3 signaling pathway", "Fluoroacetic acid toxicity", "Fluoropyrimidine activity", "Focal adhesion", "Focal adhesion pi3kaktmtorsignaling pathway", "Folate metabolism", "Folatealcohol and cancer pathway hypotheses", "Follicle stimulating hormone fsh signaling pathway", "Foxa2 pathway", "Foxp3 in covid19", "Fragile x syndrome", "Fto obesity variant mechanism", "G protein signaling pathways", "G1 to s cell cycle control", "G13 signaling pathway", "Gaba metabolism aka ghb", "Gaba receptor signaling", "Galanin receptor pathway", "Gammaglutamyl cycle for the biosynthesis and degradation of glutathione including diseases", "Gastric cancer network 1", "Gastric cancer network 2", "Gastrin signaling pathway", "Gdnfret signaling axis", "Genes associated with the development of rheumatoid arthritis", "Genes controlling nephrogenesis", "Genes related to primary cilium development based on crispr", "Genes targeted by mirnas in adipocytes", "Glial cell differentiation", "Glioblastoma signaling pathways", "Glucocorticoid receptor pathway", "Glucuronidation", "Glutathione metabolism", "Glycerolipids and glycerophospholipids", "Glycerophospholipid biosynthetic pathway", "Glycogen synthesis and degradation", "Glycolysis and gluconeogenesis", "Glycolysis in senescence", "Glycosaminoglycan degradation", "Glycosylation and related congenital defects", "Gpcrs class a rhodopsinlike", "Gpr143 in melanocytes and retinal pigment epithelium cells", "Gpr40 pathway", "H19 action rbe2f1 signaling and cdkbetacatenin activity", "Hair follicle development cytodifferentiation part 3 of 3", "Hair follicle development organogenesis part 2 of 3", "Head and neck squamous cell carcinoma", "Heart development", "Hedgehog signaling pathway wp4249", "Hedgehog signaling pathway wp47", "Hematopoietic stem cell gene regulation by gabp alphabeta complex", "Heme biosynthesis", "Hepatitis b infection", "Hepatitis c and hepatocellular carcinoma", "Hepatocyte growth factor receptor signaling", "Hereditary leiomyomatosis and renal cell carcinoma pathway", "Hif1a and pparg regulation of glycolysis", "Hijack of ubiquitination by sarscov2", "Hippo signaling regulation pathways", "Hippomerlin signaling dysregulation", "Hippoyap signaling pathway", "Histone modifications", "Homologous recombination", "Hostpathogen interaction of human coronaviruses apoptosis", "Hostpathogen interaction of human coronaviruses autophagy", "Hostpathogen interaction of human coronaviruses interferon induction", "Hostpathogen interaction of human coronaviruses mapk signaling", "Hypertrophy model", "Hypothesized pathways in pathogenesis of cardiovascular disease", "Hypothetical craniofacial development pathway", "Id signaling pathway", "Il1 signaling pathway", "Il10 antiinflammatory signaling pathway", "Il17 signaling pathway", "Il18 signaling pathway", "Il2 signaling pathway", "Il3 signaling pathway", "Il4 signaling pathway", "Il5 signaling pathway", "Il6 signaling pathway", "Il7 signaling pathway", "Il9 signaling pathway", "Imatinib and chronic myeloid leukemia", "Immune response to tuberculosis", "Inclusion body myositis", "Inflammatory response pathway", "Influence of laminopathies on wnt signaling", "Inhibition of exosome biogenesis and secretion by manumycin a in crpc cells", "Initiation of transcription and translation elongation at the hiv1 ltr", "Insulin signaling", "Insulin signaling in adipocytes diabetic condition", "Insulin signaling in adipocytes normal condition", "Integrated cancer pathway", "Integrinmediated cell adhesion", "Interactions between immune cells and micrornas in tumor microenvironment", "Interactions between loxl4 and oxidative stress pathway", "Interactome of polycomb repressive complex 2 prc2", "Interferon type i signaling pathways", "Interleukin1 il1 structural pathway", "Interleukin1 induced activation of nfkb", "Interleukin11 signaling pathway", "Intracellular trafficking proteins involved in cmt neuropathy", "Intraflagellar transport proteins binding to dynein", "Irinotecan pathway", "Iron metabolism in placenta", "Joubert syndrome", "Kallmann syndrome", "Kennedy pathway from sphingolipids", "Ketogenesis and ketolysis", "Ketone bodies synthesis and degradation", "Kininkallikrein pathway", "Kisspeptinkisspeptin receptor system in the ovary", "Kit receptor signaling pathway", "Krebs cycle disorders", "Kynurenine pathway and links to cell senescence", "Leptin and adiponectin", "Leptin signaling pathway", "Leptininsulin signaling overlap", "Leukocyteintrinsic hippo pathway functions", "Linoleic acid metabolism affected by coronavirus infection", "Lipid metabolism pathway", "Liver x receptor pathway", "Lncrna in canonical wnt signaling and colorectal cancer", "Lncrnamediated mechanisms of therapeutic resistance", "Ltf danger signal response pathway", "Lung fibrosis", "Male infertility", "Malignant pleural mesothelioma", "Mammalian disorder of sexual development", "Mammary gland development pathway embryonic development stage 1 of 4", "Mammary gland development pathway involution stage 4 of 4", "Mammary gland development pathway pregnancy and lactation stage 3 of 4", "Mammary gland development pathway puberty stage 2 of 4", "Map3k1 role in promoting and blocking gonadal determination", "Mapk and nfkb signaling pathways inhibited by yersinia yopj", "Mapk cascade", "Mapk pathway in congenital thyroid cancer", "Mapk signaling pathway", "Matrix metalloproteinases", "Mbdnf and probdnf regulation of gaba neurotransmission", "Measles virus infection", "Mechanoregulation and pathology of yaptaz via hippo and nonhippo mechanisms", "Mecp2 and associated rett syndrome", "Melanoma", "Melatonin metabolism and effects", "Mesodermal commitment pathway", "Met in type 1 papillary renal cell carcinoma", "Metabolic pathway of ldl hdl and tg including diseases", "Metabolic reprogramming in colon cancer", "Metabolism of alphalinolenic acid", "Metabolism of spingolipids in er and golgi apparatus", "Metapathway biotransformation phase i and ii", "Metastatic brain tumor", "Methionine de novo and salvage pathway", "Methionine metabolism leading to sulfur amino acids and related disorders", "Methylation pathways", "Mevalonate arm of cholesterol biosynthesis pathway", "Mevalonate pathway", "Mfap5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement", "Mfap5mediated ovarian cancer cell motility and invasiveness", "Microglia pathogen phagocytosis pathway", "Microrna network associated with chronic lymphocytic leukemia", "Micrornas in cardiomyocyte hypertrophy", "Microtubule cytoskeleton regulation", "Mir124 predicted interactions with cell cycle and differentiation", "Mir517 relationship with arcn1 and usp1", "Mirna biogenesis", "Mirna regulation of dna damage response", "Mirna regulation of p53 pathway in prostate cancer", "Mirna regulation of prostate cancer signaling pathways", "Mirnas involved in dna damage response", "Mirnas involvement in the immune response in sepsis", "Mitochondrial complex i assembly model oxphos system", "Mitochondrial complex ii assembly", "Mitochondrial complex iii assembly", "Mitochondrial complex iv assembly", "Mitochondrial fatty acid synthesis pathway", "Mitochondrial gene expression", "Mitochondrial immune response to sarscov2", "Mitochondrial long chain fatty acid betaoxidation", "Modulators of tcr signaling and t cell activation", "Monoamine transport", "Mrna processing", "Mrna protein and metabolite inducation pathway by cyclosporin a", "Mthfr deficiency", "Myd88 distinct inputoutput pathway", "Myometrial relaxation and contraction pathways", "Nad biosynthetic pathways", "Nad metabolism", "Nad metabolism in oncogeneinduced senescence and mitochondrial dysfunctionassociated senescence", "Nad metabolism sirtuins and aging", "Nanomaterial induced apoptosis", "Nanoparticle triggered autophagic cell death", "Nanoparticle triggered regulated necrosis", "Nanoparticlemediated activation of receptor signaling", "Ncrnas involved in stat3 signaling in hepatocellular carcinoma", "Ncrnas involved in wnt signaling in hepatocellular carcinoma", "Neovascularisation processes", "Nephrogenesis", "Nephrotic syndrome", "Netrinunc5b signaling pathway", "Network map of sarscov2 signaling pathway", "Neural crest cell migration during development", "Neural crest cell migration in cancer", "Neural crest differentiation", "Neurodegeneration with brain iron accumulation nbia subtypes pathway", "Neuroinflammation", "Neuroinflammation and glutamatergic signaling", "Nicotine effect on dopaminergic neurons", "Nipbl role in dna damage cornelia de lange syndrome", "Nitric oxide metabolism in cystic fibrosis", "Nocgmppkg mediated neuroprotection", "Nodlike receptor nlr signaling pathway", "Nonalcoholic fatty liver disease", "Nongenomic actions of 125 dihydroxyvitamin d3", "Nonhomologous end joining", "Nonsmall cell lung cancer", "Notch signaling", "Notch signaling pathway", "Notch1 regulation of endothelial cell calcification", "Novel intracellular components of rigilike receptor rlr pathway", "Nrf2 pathway", "Nrf2are regulation", "Nrp1triggered signaling pathways in pancreatic cancer", "Nsp1 from sarscov2 inhibits translation initiation in the host cell", "Nuclear receptors in lipid metabolism and toxicity", "Nuclear receptors metapathway", "Nucleotide excision repair", "Nucleotide excision repair in xeroderma pigmentosum", "Nucleotide metabolism", "Nucleotidebinding oligomerization domain nod pathway", "Oligodendrocyte specification and differentiation leading to myelin components for cns", "Omega3 omega6 fatty acid synthesis", "Omega9 fatty acid synthesis", "Oncostatin m signaling pathway", "Onecarbon metabolism", "Onecarbon metabolism and related pathways", "Orexin receptor pathway", "Osteoblast differentiation and related diseases", "Osteoblast signaling", "Osteoclast signaling", "Osteopontin signaling", "Osx and mirnas in tooth development", "Ovarian infertility", "Overlap between signal transduction pathways contributing to lmna laminopathies", "Overview of interferonsmediated signaling pathway", "Overview of nanoparticle effects", "Oxidation by cytochrome p450", "Oxidative damage response", "Oxidative phosphorylation", "Oxidative stress response", "Oxysterols derived from cholesterol", "P38 mapk signaling pathway", "P53 transcriptional gene network", "Pancreatic adenocarcinoma pathway", "Parkinsons disease pathway", "Parkinubiquitin proteasomal system pathway", "Pathogenesis of sarscov2 mediated by nsp9nsp10 complex", "Pathogenic escherichia coli infection", "Pathways affected in adenoid cystic carcinoma", "Pathways of nucleic acid metabolism and innate immune sensing", "Pdgf pathway", "Pdgfrbeta pathway", "Pentose phosphate metabolism", "Pentose phosphate pathway in senescent cells", "Peroxiredoxin 2 induced ovarian failure", "Phase i biotransformations non p450", "Phosphodiesterases in neuronal function", "Phosphoinositides metabolism", "Photodynamic therapyinduced ap1 survival signaling", "Photodynamic therapyinduced hif1 survival signaling", "Photodynamic therapyinduced nfe2l2 nrf2 survival signaling", "Photodynamic therapyinduced unfolded protein response", "Physicochemical features and toxicityassociated pathways", "Physiological and pathological hypertrophy of the heart", "Pi3kakt signaling pathway", "Pi3kaktmtor signaling pathway and therapeutic opportunities", "Pi3kaktmtor vitd3 signaling", "Pilocytic astrocytoma", "Pkcgamma calcium signaling pathway in ataxia", "Ppar signaling pathway", "Pparalpha pathway", "Praderwilli and angelman syndrome", "Pregnane x receptor pathway", "Preimplantation embryo", "Primary focal segmental glomerulosclerosis fsgs", "Prion disease pathway", "Progeriaassociated lipodystrophy", "Prolactin signaling pathway", "Prostaglandin and leukotriene metabolism in senescence", "Prostaglandin synthesis and regulation", "Proteasome degradation", "Proteoglycan biosynthesis", "Proximal tubule transport", "Ptf1a related regulatory pathway", "Purine metabolism", "Purine metabolism and related disorders", "Purinergic signaling", "Pyrimidine metabolism", "Pyrimidine metabolism and related diseases", "Rac1pak1p38mmp2 pathway", "Rala downstream regulated genes", "Ranklrank signaling pathway", "Ras and bradykinin pathways in covid19", "Ras signaling", "Regucalcin in proximal tubule epithelial kidney cells", "Regulation of actin cytoskeleton", "Regulation of apoptosis by parathyroid hormonerelated protein", "Regulation of sister chromatid separation at the metaphaseanaphase transition", "Regulation of wnt bcatenin signaling by small molecule compounds", "Regulatory circuits of the stat3 signaling pathway", "Relationship between inflammation cox2 and egfr", "Reninangiotensinaldosterone system raas", "Resistin as a regulator of inflammation", "Retinoblastoma gene in cancer", "Rett syndrome causing genes", "Riboflavin and coq disorders", "Robo4 and vegf signaling pathways crosstalk", "S1p receptor signal transduction", "Sars coronavirus and innate immunity", "Sarscov2 altering angiogenesis via nrp1", "Sarscov2 and covid19 pathway", "Sarscov2 b117 variant antagonises innate immune activation", "Sarscov2 innate immunity evasion and cellspecific immune response", "Selenium micronutrient network", "Serine metabolism", "Serotonin htr1 group and fos pathway", "Serotonin receptor 2 and elksrfgata4 signaling", "Serotonin receptor 467 and nr3c signaling", "Serotonin transporter activity", "Signal transduction through il1r", "Sleep regulation", "Small cell lung cancer", "Smc1smc3 role in dna damage cornelia de lange syndrome", "Somatroph axis gh and its relationship to dietary restriction and aging", "Sphingolipid metabolism in senescence", "Sphingolipid metabolism integrated pathway", "Sphingolipid metabolism overview", "Sphingolipid pathway", "Spinal cord injury", "Splicing factor nova regulated synaptic proteins", "Srebf and mir33 in cholesterol and lipid homeostasis", "Srf and mirs in smooth muscle differentiation and proliferation", "Statin inhibition of cholesterol production", "Steroid biosynthesis", "Sterol regulatory elementbinding proteins srebp signaling", "Sting pathway in kawasakilike disease and covid19", "Striated muscle contraction pathway", "Sudden infant death syndrome sids susceptibility pathways", "Sulfation biotransformation reaction", "Supression of hmgb1 mediated inflammation by thbd", "Synaptic signaling pathways associated with autism spectrum disorder", "Synaptic vesicle pathway", "T cell receptor and costimulatory signaling", "Target of rapamycin tor signaling", "Tca cycle aka krebs or citric acid cycle", "Tca cycle and deficiency of pyruvate dehydrogenase complex pdhc", "Tca cycle in senescence", "Tca cycle nutrient use and invasiveness of ovarian cancer", "Tcell activation sarscov2", "Tcell antigen receptor tcr pathway during staphylococcus aureus infection", "Tcell receptor tcr signaling pathway", "Tgfbeta receptor signaling", "Tgfbeta receptor signaling in skeletal dysplasias", "Tgfbeta signaling in thyroid cells for epithelialmesenchymal transition", "Tgfbeta signaling pathway", "Thermogenesis", "Thiamine metabolic pathways", "Thymic stromal lymphopoietin tslp signaling pathway", "Thyroid hormones production and peripheral downstream signaling effects", "Thyroid stimulating hormone tsh signaling pathway", "Tlr4 signaling and tolerance", "Tnfalpha signaling pathway", "Tnfrelated weak inducer of apoptosis tweak signaling pathway", "Tolllike receptor signaling pathway", "Tolllike receptor signaling related to myd88", "Tp53 network", "Transcription cofactors ski and skil protein partners", "Transcription factor regulation in adipogenesis", "Transcription factors regulate mirnas related to cardiac hypertrophy", "Transcriptional activation by nrf2 in response to phytochemicals", "Translation factors", "Translation inhibitors in chronically activated pdgfra cells", "Transsulfuration and onecarbon metabolism", "Transsulfuration pathway", "Triacylglyceride synthesis", "Tryptophan catabolism leading to nad production", "Tryptophan metabolism", "Tumor suppressor activity of smarcb1", "Type 2 papillary renal cell carcinoma", "Type i collagen synthesis in the context of osteogenesis imperfecta", "Type i interferon induction and signaling during sarscov2 infection", "Type ii diabetes mellitus", "Type ii interferon signaling ifng", "Type iii interferon signaling", "Tyrobp causal network in microglia", "Ultraconserved region 339 modulation of tumor suppressor micrornas in cancer", "Unfolded protein response", "Urea cycle and associated pathways", "Urea cycle and metabolism of amino groups", "Urea cycle and related diseases", "Valproic acid pathway", "Vasopressinregulated water reabsorption", "Vegfavegfr2 signaling pathway", "Vitamin a and carotenoid metabolism", "Vitamin b12 disorders", "Vitamin b12 metabolism", "Vitamin b6dependent and responsive disorders", "Vitamin d in inflammatory diseases", "Vitamin d metabolism", "Vitamin d receptor pathway", "Vitamin dsensitive calcium signaling in depression", "White fat cell differentiation", "Wnt signaling", "Wnt signaling in kidney disease", "Wnt signaling pathway", "Wnt signaling pathway and pluripotency", "Wntbetacatenin signaling pathway in leukemia", "Zinc homeostasis"], "available_proteins": ["AAMP", "AAR2", "AARS", "AASS", "ABCB1", "ABCD3", "ABCF1", "ABCF2", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR2", "ACTR3", "ADA", "ADAR", "ADH5", "ADI1", "ADK", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK4", "AKAP1", "AKAP12", "AKAP8", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "AKT2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALG9", "AMOT", "ANAPC1", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANLN", "ANXA1", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "AP1G1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "APC", "APEX1", "APMAP", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARG2", "ARHGDIA", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID4B", "ARIH2", "ARL2", "ARL3", "ARL6", "ARL8B", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC1", "ASCC3", "ASF1A", "ASNA1", "ASNS", "ATAD2", "ATG13", "ATG3", "ATIC", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0D1", "ATP6V1A", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATP7B", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2", "ATXN2L", "AURKA", "B3GALT6", "BAG2", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCKDK", "BCL10", "BCL2L13", "BCLAF1", "BCS1L", "BLVRA", "BLVRB", "BRAP", "BRCA1", "BRD1", "BRD4", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "C1QBP", "CAB39", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAND1", "CAP1", "CAPN1", "CAPN2", "CAPZB", "CARM1", "CASK", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CC2D1A", "CCAR2", "CCDC124", "CCDC6", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD47", "CDC23", "CDC27", "CDC37", "CDC42", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDK7", "CDK9", "CDKAL1", "CDS2", "CEBPZ", "CELF1", "CELF2", "CEP170", "CEP290", "CEP44", "CETN2", "CFL1", "CFL2", "CHAF1A", "CHAMP1", "CHD1", "CHD1L", "CHD4", "CHD8", "CHEK2", "CHKA", "CHMP5", "CHORDC1", "CHP1", "CHRAC1", "CHST14", "CIP2A", "CISD1", "CKB", "CLASP2", "CLIC1", "CLPTM1L", "CLTA", "CLTB", "CLTC", "CLUH", "CMPK1", "CNN2", "CNOT1", "CNOT9", "CNP", "COA3", "COASY", "COLEC12", "COLGALT1", "COMMD1", "COMT", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COQ8A", "COX11", "COX14", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7A2L", "COX7C", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPT1A", "CPT2", "CRK", "CRKL", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK1E", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CXADR", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAG1", "DAGLB", "DARS", "DBNL", "DCAF1", "DCAF7", "DCTN1", "DCTN2", "DCTN4", "DCTPP1", "DDAH2", "DDB1", "DDOST", "DDX1", "DDX17", "DDX20", "DDX21", "DDX3X", "DDX5", "DDX52", "DDX56", "DEGS1", "DEK", "DERL1", "DFFA", "DGCR8", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX36", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DICER1", "DLAT", "DLD", "DLG1", "DLGAP5", "DLST", "DNAAF5", "DNAJA1", "DNAJB1", "DNAJB11", "DNAJC3", "DNAJC7", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DOCK1", "DPF2", "DPM1", "DPP9", "DPYSL2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECSIT", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFTUD2", "EHD1", "EHHADH", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF4A1", "EIF4A2", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAVL1", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP3", "EMD", "EML4", "ENAH", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX1", "EPRS", "EPS15", "EPS15L1", "ERCC3", "ESD", "ESS2", "ETF1", "ETFA", "ETFDH", "EWSR1", "EXO1", "EXOC2", "EXOC4", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOSC2", "EXOSC4", "EXOSC7", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAH", "FAM120A", "FANCD2", "FANCI", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FECH", "FEN1", "FGFR1OP", "FH", "FHL1", "FHOD1", "FKBP10", "FKBP2", "FKBP4", "FKBP5", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FNTA", "FOXRED1", "FSCN1", "FTL", "FTO", "FUCA1", "FUS", "FXR1", "FXR2", "G3BP1", "G6PD", "GABARAPL2", "GALNT1", "GAPDH", "GART", "GBA", "GCC2", "GCDH", "GCLC", "GDAP1", "GDI1", "GFPT1", "GGCT", "GGCX", "GGH", "GGPS1", "GID4", "GIGYF2", "GIPC1", "GLA", "GLB1", "GLS", "GLUD1", "GM2A", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAO1", "GNPAT", "GNS", "GOT1", "GOT2", "GPAT4", "GPD1L", "GPD2", "GPI", "GPS1", "GPT2", "GRB2", "GRSF1", "GSK3A", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2H4", "GTF2I", "GTPBP4", "GUSB", "GYG1", "GYS1", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HADH", "HADHA", "HADHB", "HAT1", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HEBP1", "HELLS", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGCL", "HMGCR", "HMGCS1", "HMGN1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HTRA2", "HTT", "HUS1", "HYOU1", "IARS", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IFT88", "IGF2BP1", "IGF2BP3", "IKBKG", "ILF2", "IMP3", "IMPAD1", "IMPDH1", "IMPDH2", "INF2", "INPP4A", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "IRF2BPL", "IRS4", "ITGAV", "ITGB1", "ITPA", "IVD", "JUP", "KAT7", "KDM1A", "KDM1B", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIF22", "KIF23", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KLC1", "KLC4", "KPNA1", "KPNA4", "KPNB1", "KTN1", "L2HGDH", "LAMB1", "LARP1", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LEMD3", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIPA", "LLGL1", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LRPPRC", "LRRC59", "LRRC8C", "LRWD1", "LSM2", "LSM4", "LSS", "LTA4H", "LUC7L", "LZTFL1", "MACF1", "MAD2L1", "MAGT1", "MANF", "MAP1B", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARK2", "MARS", "MAT2A", "MAT2B", "MAVS", "MBD3", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCU", "MDC1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED1", "MED14", "MEPCE", "METTL3", "MFAP1", "MFN2", "MGST2", "MGST3", "MIA3", "MIF", "MKI67", "MMAB", "MOGS", "MORF4L1", "MOV10", "MPC2", "MPG", "MPI", "MPP1", "MPP2", "MPST", "MRE11", "MRPL19", "MRPL40", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTOR", "MTR", "MUT", "MVD", "MYBBP1A", "MYCBP", "MYCBP2", "MYEF2", "MYH10", "MYH9", "MYL6", "MYO1C", "MYO6", "NAA15", "NAA40", "NAA50", "NAE1", "NAGLU", "NAMPT", "NAP1L1", "NAPA", "NARS", "NAT10", "NBN", "NCAPG", "NCAPG2", "NCBP1", "NCDN", "NCKAP1", "NCL", "NCOR1", "NCSTN", "ND5", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB11", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS5", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFB", "NELFCD", "NELFE", "NF1", "NFATC2IP", "NFRKB", "NIPBL", "NKRF", "NME1", "NME2", "NONO", "NOP2", "NPC1", "NPC2", "NPHP3", "NRP1", "NSD1", "NSDHL", "NSF", "NT5C3A", "NUDC", "NUDT21", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP214", "NUP62", "NUP88", "NUP98", "NXF1", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OPA1", "ORC2", "ORC3", "ORC5", "OXCT1", "OXSR1", "P3H1", "P4HA1", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PAICS", "PAK2", "PAK4", "PAPOLA", "PAPSS1", "PARK7", "PARN", "PARP1", "PARP2", "PBK", "PBRM1", "PBXIP1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCM1", "PCNA", "PDCD6", "PDCD6IP", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA6", "PDK1", "PDLIM5", "PDS5A", "PDS5B", "PDSS2", "PEBP1", "PECR", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PHB", "PHB2", "PHF5A", "PHF6", "PHGDH", "PI4K2A", "PI4KA", "PIGT", "PIK3C2A", "PIK3R2", "PIP4K2C", "PISD", "PKM", "PKMYT1", "PKN2", "PLCG1", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PMPCA", "PMVK", "PNP", "PNPT1", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLE", "POLE2", "POLE4", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR2L", "POLR3A", "POLR3C", "POLR3E", "POLRMT", "PON2", "POR", "PPAT", "PPIB", "PPID", "PPIF", "PPM1G", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R14B", "PPP1R9B", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPT2", "PRCC", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF3", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSPC1", "PSPH", "PTBP1", "PTBP2", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PURA", "PUS1", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QKI", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB21", "RAB23", "RAB2A", "RAB3B", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RABAC1", "RABGAP1", "RABGEF1", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RALA", "RAN", "RANBP1", "RANGAP1", "RAPGEF2", "RARS", "RASA1", "RBM14", "RBM17", "RBM39", "RBM4", "RBM47", "RBM5", "RBMX", "RBPJ", "RCC1", "RCN1", "RDH14", "RDX", "RECQL", "RETSAT", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RIF1", "RIPK1", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF40", "RNMT", "RNPS1", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPA3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPRD1B", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS27", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRAS2", "RRBP1", "RRM1", "RRM2", "RTCB", "RTF1", "RTN3", "RTN4", "RUVBL1", "S100A10", "S100A11", "SACM1L", "SAFB", "SAMHD1", "SAP18", "SAR1A", "SARS", "SC5D", "SCAF11", "SCAMP2", "SCAP", "SCARB1", "SCARB2", "SCD", "SCO1", "SCO2", "SCP2", "SCRIB", "SDCBP", "SDHA", "SDHB", "SEC13", "SEC23A", "SEC23B", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEL1L", "SEPT11", "SERBP1", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETDB1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SFPQ", "SFSWAP", "SGPL1", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SHOC2", "SIN3A", "SIRT1", "SIRT2", "SKP1", "SKP2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A19", "SLC25A20", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC2A8", "SLC30A5", "SLC30A9", "SLC35B2", "SLC38A1", "SLC39A14", "SLC3A2", "SLC4A7", "SLC7A1", "SLIT2", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMS", "SNAP23", "SNAP29", "SND1", "SNIP1", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SOAT1", "SOD2", "SPEN", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRM", "SRP54", "SRPK1", "SRRM1", "SRSF1", "SRSF10", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSR3", "SSR4", "STAG1", "STAG2", "STAM", "STAMBP", "STAT1", "STAT3", "STIP1", "STK38", "STK4", "STMN1", "STRAP", "STRN", "STUB1", "STX4", "STXBP3", "STXBP4", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT5H", "SUZ12", "SYNE1", "SYNE2", "TAB1", "TALDO1", "TARDBP", "TBC1D10A", "TBC1D4", "TBCA", "TBL2", "TCP1", "TDP2", "TECR", "TELO2", "TERF2IP", "TFAM", "TFB1M", "TFCP2", "TFRC", "THRAP3", "TIGAR", "TIMELESS", "TIMMDC1", "TIPRL", "TJP1", "TJP2", "TK1", "TKFC", "TKT", "TLN1", "TLN2", "TMED10", "TMEM126B", "TMEM43", "TMEM70", "TMOD3", "TMPO", "TMPO", "TNKS1BP1", "TNPO1", "TOLLIP", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOR1AIP1", "TP53", "TP53BP1", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRIM25", "TRIM28", "TRIM33", "TRIO", "TRIP10", "TRIP13", "TRIP4", "TRMT2A", "TRRAP", "TSC2", "TSG101", "TSPO", "TSPYL1", "TTC19", "TTC26", "TTF2", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TXNDC5", "TXNL4A", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "UBA1", "UBA3", "UBAP2L", "UBE2G2", "UBE2L3", "UBE2N", "UBE3A", "UBR5", "UBTF", "UBXN7", "UCHL5", "UCK2", "UFD1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNG", "UPF1", "UQCC1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "UROD", "USMG5", "USP10", "USP5", "USP7", "USP9X", "UTRN", "VANGL1", "VAPA", "VAPB", "VARS1", "VBP1", "VCL", "VDAC1", "VDAC2", "VDAC3", "VIM", "VMP1", "VPS16", "VPS18", "VPS33A", "VPS37B", "VPS4A", "WAPL", "WARS", "WDR1", "WDR26", "WDR5", "WDR73", "WDR74", "WFS1", "WIPI2", "XAB2", "XPA", "XPNPEP3", "XPO1", "XPO5", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H15", "ZFR", "ZFYVE16", "ZMPSTE24", "ZNF281", "ZNF318", "ZYX"], "leading_proteins": ["ABCB1", "ACAT2", "ACOX1", "ACOX3", "ACP6", "ACSL1", "ACSL3", "ACSL4", "AGPS", "AIFM1", "AKT2", "ALG1", "ALG12", "ALG9", "APC", "ASAH1", "ASNA1", "ATP1A1", "ATP1B1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP5B", "ATP5F1", "ATP5I", "ATP5L", "ATP6", "ATP6AP1", "ATP7A", "ATP7B", "BCS1L", "CDK9", "CDKAL1", "CDS2", "CHKA", "CHST14", "CISD1", "CLPTM1L", "COA3", "COMT", "COX11", "COX14", "COX15", "COX2", "COX4I1", "COX5A", "COX7A2", "CPT1A", "CPT2", "CRTAP", "CTNNA1", "CTNNB1", "CYB5B", "CYP20A1", 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sha256:65a2cde4b8211f306894a063fc0348e22ee4d4e14f103db761eb73d0e9b7f901 +size 174110 diff --git a/opencell_localization/basic/idx2term.json b/opencell_localization/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..15b387fe9150b21ca75ddf723d5eb4aa933b2fbb --- /dev/null +++ b/opencell_localization/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "er", "1": "golgi", "2": "mitochondria", "3": "vesicles", "4": "nuclear_membrane"} \ No newline at end of file diff --git a/opencell_localization/basic/plot_0.png b/opencell_localization/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..3d15183090d7a8992e015f9ee7bdd096d90c5473 --- /dev/null +++ b/opencell_localization/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:bb355c726b4b5a01a1a1c87feb6affb53425a90498c59800a377f1b4ff766b21 +size 134654 diff --git a/opencell_localization/basic/plot_1.png b/opencell_localization/basic/plot_1.png new 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a/opencell_localization/df_merge.tsv b/opencell_localization/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..2223047b6cef24867ff2d89ea9e6db6d9d6ff011 --- /dev/null +++ b/opencell_localization/df_merge.tsv @@ -0,0 +1,4 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +er 44 89 4.128410737254409 3.652791893471452e-05 29.17233009708738 87.61893203883496 1.3358083950399515 0.3757472714196316 13.465054065187209 8.223393744963309 2.0429537263872786 0.4010648005920765 4.5771684406774825e-17 0.0289961107043292 0.0004218307298906 1.2014586751787764e-09 2.488408614772039e-21 +golgi 27 66 2.7437919023076613 0.006073402485625 15.631067961165048 61.19417475728155 0.6692399314943925 0.523533703348586 6.922582002252161 5.868805558877078 1.075539554450533 0.3729249549278102 3.710395812410707e-05 0.0817104171385654 0.0731929968318565 0.000724477579467 6.355394516845297e-06 +mitochondria 7 10 2.7238860440431623 0.0064518763856844 4.441747572815534 10.567961165048544 1.1937677940164793 0.2159787381789819 2.254231157409949 0.7391563798220593 1.4011905974754153 0.2980089661914649 8.985506357909055e-05 2.7096103204179448e-05 5.369271916582234e-06 0.0001991597833083 1.6279070379868977e-05 diff --git a/opencell_localization/metrics.json b/opencell_localization/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..d60b1404f3b40c7b513b3ec0af584f015e3e7817 --- /dev/null +++ b/opencell_localization/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3120, + "annotations_size": 17, + "title": "Average number of proteins per term", + "value": 96.29411764705883 +} \ No newline at end of file diff --git a/opencell_localization/paths.json b/opencell_localization/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..f742fdb0dab8f07ec2cccc680ed99b05fd403146 --- /dev/null +++ b/opencell_localization/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/opencell_localization/fragment/C390/C390_val_log2fc"} \ No newline at end of file diff --git a/opencell_localization/result.tsv b/opencell_localization/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..dc888b62dbc0dea6681e28f0b566b4dcc8ea2e62 --- /dev/null +++ b/opencell_localization/result.tsv @@ -0,0 +1,6 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +er 0.6374804841999726 4.128410737254409 3.652791893471452e-05 0.0006207931917431 0.0006209746218901 89 Q9Y487,Q8N4V1,Q15363,Q15006,Q96GC9,P61026,Q9UM00,P46977,Q9NTJ5,Q9P2W9,Q06136,Q9NPA0,Q15392,Q15041,O15269,Q9Y3E0,Q96N66,Q8NF37,Q07065,Q8NHH9,Q9NR31,Q9BVG9,Q00765,Q8NC56,Q969Q5,Q9H6H4,O95674,P27824,Q5HYI8,Q9NQC3,Q969V3,Q9Y5M8,O60499,P51572,P49755,Q12981,O75845,O96005,P04843,O95470,Q16850,Q99640,O00264,Q96A33 44 +golgi 0.4736239708936111 2.7437919023076613 0.006073402485625 0.0983804658443606 0.0274204746391589 66 Q9Y487,Q8NBN3,P61026,Q9UM00,P61019,Q9NTJ5,Q15907,Q9Y3E0,Q9UI14,Q13190,Q9NR31,Q8IXU6,O15127,Q8TAD4,Q15904,Q9H0U4,Q8N6T3,O15258,P53367,P49755,O15126,Q8IZA0,Q96A49,Q9BXB4,Q9Y371,Q5VW38,O75787 27 +mitochondria 0.8121781370846852 2.7238860440431623 0.0064518763856844 0.1041992382782547 0.0274204746391589 10 Q15388,P45880,Q9NR31,O95140,Q9Y277,P21796,Q969Q5 7 +vesicles 0.4172957486559049 0.8481633581922517 0.3963470004695266 0.9998123341844674 0.7442737118017163 180 Q8N668,P41440,Q8IY95,O15400,Q8NBN3,Q15363,P20020,P61026,Q15738,Q9UM00,P61019,Q06136,Q15392,P11279,O43808,Q15907,O15269,Q9UI14,Q9Y3E0,P31751,Q8NF37,Q13501,Q9Y3E7,Q8IXU6,O15127,Q8IZ07,O43752,Q10713,P49257,P00387,Q9NY64,O60826,Q15904,Q9H6H4,P04439,O60749,Q9H0U4,Q9UQN3,Q5HYI8,O95674,O60476,P05023,Q969V3,Q86Y82,P30825,Q8N6T3,Q9HD42,O00459,O60499,O95249,O15258,P53367,P49755,Q9H9H4,O15126,Q93050,Q8IZA0,Q96A49,Q9BXB4,P61020,O75845,Q92783,O96005,P13473,O95470,Q96PE3,Q9Y5X3,Q9Y371,Q15758,Q9P253,Q5VW38,O75787,P02786,O75396,O00264 75 +nuclear_membrane 0.2698668814385414 0.0728287211103338 0.9419424154972922 1.0 1.0 31 Q9C0E2,P20700,Q8NFH5,Q9Y2U8,P02545,P42167,Q8NC56,P52292 8 diff --git a/opencell_localization/selections.json b/opencell_localization/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..8bbccf6ac61a2c926da76403de0699e4f58ec089 --- /dev/null +++ b/opencell_localization/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["big_aggregates", "cell_contact", "centrosome", "chromatin", "cytoplasmic", "cytoskeleton", "er", "focal_adhesions", "golgi", "membrane", "mitochondria", "nuclear_membrane", "nuclear_punctae", "nucleolus_fc_dfc", "nucleolus_gc", "nucleoplasm", "vesicles"], "available_proteins": ["AAMP", "AATF", "ABCE1", "ACLY", "ACTN1", "ACTN4", "ACTR2", "AHCY", "AHSA1", "AKAP12", "AKAP8L", "AKR1A1", "AKT1S1", "AKT2", "ALCAM", "ALDH9A1", "ANAPC16", "ANAPC2", "ANAPC4", "ANKRD13A", "ANXA11", "AP2B1", "AP2S1", "APC", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARHGAP17", "ARHGEF7", "ARID1A", "ARL1", "ARL2", "ARL3", "ARL6", "ARL6IP1", "ARL6IP5", "ARL8B", "ARPC2", "ARPC3", "ATG13", "ATG3", "ATG4B", "ATL2", "ATP1A1", "ATP2B1", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATP6V1H", "ATXN10", "ATXN2L", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAP31", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOP1", "BPNT1", "BRD2", "BRD3", "BRD4", "BTF3", "BUB1B", "BUD23", "BYSL", "C1orf123", "C7orf50", "C8orf33", "CAD", "CALD1", "CAMK2G", "CANX", "CAPRIN1", "CAPZB", "CBX1", "CCAR1", "CCDC22", "CCDC47", "CCDC86", "CCDC93", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CCZ1B", "CD2BP2", "CDC23", "CDC27", "CDC37", "CDC42", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK7", "CDK9", "CDS2", "CEP170", "CETN2", "CHEK2", "CHMP1A", "CHMP2B", "CHMP3", "CHMP4B", "CHMP7", "CKAP2", "CKAP4", "CKAP5", "CKB", "CLASP2", "CLINT1", "CLNS1A", "CLPTM1", "CLTA", "CLTB", "CLTC", "CNN2", "COIL", "COMMD1", "COMMD4", "COPA", "COPB2", "COPE", "COPG1", "COPG2", "COPZ1", "CORO1C", "CPSF6", "CSE1L", "CSK", "CSNK1A1", "CSNK1E", "CSNK2A2", "CSNK2B", "CTBP1", "CTBP2", "CTCF", "CTNNB1", "CTNNBL1", "CTPS1", "CTTN", "CYB5R3", "CYP51A1", "DAD1", "DBNL", "DCP1B", "DCTN2", "DDB1", "DDOST", "DDX21", "DDX39B", "DDX47", "DDX5", "DDX56", "DDX6", "DEGS1", "DHCR24", "DHX37", "DHX9", "DIAPH1", "DKC1", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DOCK7", "DPH2", "DRG1", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "DYNLL2", "EBNA1BP2", "EDC3", "EDC4", "EDF1", "EEA1", "EEF1G", "EFTUD2", "EIF2AK2", "EIF3B", "EIF3E", "EIF3G", "EIF3I", "EIF3K", "EIF3M", "EIF4A1", "EIF4A3", "EIF5", "EMC1", "EMC2", "EMC3", "EMC4", "EMC7", "EMC8", "EMG1", "ENO1", "EPS15", "ESD", "ESYT1", "EWSR1", "EZR", "FAM120A", "FASN", "FAU", "FBL", "FDPS", "FKBP5", "FKBP8", "FNBP1", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAK", "GAPDH", "GAR1", "GBF1", "GDI1", "GDI2", "GET4", "GGPS1", "GNL2", "GNL3", "GOLGA2", "GOLT1B", "GORASP2", "GOSR1", "GOSR2", "GPAT4", "GPR107", "GRB2", "GSK3A", "GSK3B", "GSPT1", "GTPBP4", "GYG1", "GYS1", "H1F0", "HDAC1", "HDAC2", "HEATR3", "HGS", "HLA-A", "HMGA1", "HMGB2", "HMGCS1", "HNRNPA0", "HNRNPC", "HNRNPD", "HNRNPH1", "HNRNPL", "HNRNPU", "HSP90AA1", "HSP90AB1", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPB1", "HSPBP1", "HSPH1", "HUS1", "IDI1", "IGF2BP1", "IGF2BP3", "ILF3", "IMP3", "INPP4A", "INTS14", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IST1", "KDSR", "KIAA0319L", "KIAA0368", "KIF11", "KIF20A", "KIF22", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KLC1", "KLC4", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "LAMP1", "LAMP2", "LAMTOR2", "LARP7", "LBR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LIG1", "LMAN1", "LMNA", "LMNB1", "LNPK", "LPCAT1", "LSM14B", "LSS", "LTV1", "MAN1A2", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MARK2", "MBOAT7", "MCM10", "MDH1", "MECP2", "MED14", "MED24", "MED4", "METAP2", "MFN2", "MIF", "MKI67", "MMGT1", "MPHOSPH10", "MRTO4", "MSH6", "MSN", "MTOR", "MVD", "MYBBP1A", "MYH10", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO6", "NAF1", "NANS", "NAPA", "NCAPH", "NCKAP1", "NCL", "NCLN", "NECAP1", "NECAP2", "NEK9", "NEMF", "NHP2", "NIFK", "NOL10", "NOL11", "NOM1", "NONO", "NOP10", "NOP2", "NOP58", "NPM1", "NRBP1", "NSA2", "NSDHL", "NUCKS1", "NUFIP2", "NUMA1", "NUP107", "NUP153", "NUP155", "NUP214", "NUP35", "NUP98", "NUTF2", "NVL", "NXF1", "OCRL", "OSBP", "OSBPL11", "OSBPL8", "OXSR1", "PABPC4", "PACSIN2", "PACSIN3", "PAK2", "PAK4", "PARP1", "PBK", "PCNA", "PDAP1", "PDCD11", "PDCD6", "PDCD6IP", "PDCL3", "PES1", "PFDN6", "PFN1", "PGK1", "PGRMC1", "PHAX", "PHF10", "PHGDH", "PI4K2A", "PI4KA", "PICALM", "PIK3C2A", "PIK3R2", "PIN4", "PIP4K2C", "PKM", "PKMYT1", "PKN2", "PLK1", "PMPCA", "PMVK", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR3A", "POLR3C", "POLR3E", "PPM1G", "PRKACA", "PRKCD", "PRKDC", "PRMT9", "PRPF19", "PRPF4B", "PRPF8", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSME1", "PSME2", "PSME3", "PSMG1", "PSMG3", "PSPC1", "PTDSS1", "PTDSS2", "PTGES3", "PTK7", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB7A", "RABAC1", "RABEP1", "RABGAP1", "RABGGTA", "RABL3", "RAC1", "RACK1", "RAD21", "RAN", "RANBP1", "RANBP2", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM5", "RBM6", "RBM7", "RBM8A", "RBMX", "REEP4", "REEP5", "RER1", "RHOA", "RIOK2", "RNASEH2A", "RNF40", "ROCK1", "RPL10A", "RPL11", "RPL13", "RPL19", "RPL27", "RPL35", "RPL4", "RPL5", "RPN1", "RPN2", "RPP30", "RPS11", "RPS14", "RPS16", "RPS18", "RPS6KA1", "RPS6KA3", "RRP1", "RRP36", "RSL1D1", "RTCB", "RTN4", "RUVBL1", "RUVBL2", "S100A10", "SACM1L", "SAE1", "SAR1A", "SARS", "SBDS", "SC5D", "SCAMP1", "SCAMP2", "SCAMP4", "SCD", "SCFD1", "SCYL2", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC24C", "SEC24D", "SEC31A", "SEC61B", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SGPL1", "SH3GL1", "SH3GLB1", "SH3GLB2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A17", "SLC27A4", "SLC2A1", "SLC2A8", "SLC30A5", "SLC35F2", "SLC7A1", "SLC9A3R1", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMN1*", "SNRNP40", "SNRPA", "SNRPB2", "SNRPC", "SNRPD2", "SNU13", "SNX1", "SNX17", "SNX2", "SNX3", "SNX5", "SNX9", "SPTLC1", "SPTLC2", "SQSTM1", "SRI", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPRA", "SRPRB", "SSB", "SSRP1", "STAG1", "STAG2", "STAM", "STIP1", "STK26", "STK4", "STT3A", "STT3B", "STX10", "STX12", "STX18", "STX5", "STX6", "STX7", "STX8", "SUPT16H", "SUPT5H", "SYAP1", "TARDBP", "TCOF1", "TFRC", "TIA1", "TJP1", "TJP2", "TMA16", "TMCO1", "TMED10", "TMED2", "TMEM192", "TMEM87A", "TMPO", "TMPO", "TNPO1", "TNPO3", "TOLLIP", "TOMM20", "TOMM70", "TOP1", "TOP2A", "TOR1AIP1", "TPR", "TPT1", "TRIM28", "TRIM33", "TRIR", "TRMT1L", "TRRAP", "TSG101", "TSR1", "TTK", "TUBB4B", "TUBG1", "U2AF2", "U2SURP", "UBA1", "UBA5", "UBE2M", "UBTF", 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0.0225021529012443 4.660194174757281 11.12378640776699 0.9288896561072936 0.3201954718639376 2.5506648592929815 2.745113440103806 1.1546709449924732 0.3042666981599379 0.0049407674184341 0.1280604643503683 0.0026246094830452 0.0005802452812718 0.0023211498250519 +serine protease 5 17 2.2080035337635917 0.0272440268297879 5.662621359223301 17.516990291262136 1.1445634795625386 0.1820139001244477 2.0809494011218104 1.6626107291843584 1.568325484830445 0.2384821649427795 0.0117944261645624 0.0221752921749746 0.0001009929501613 0.0063027604866002 0.0089113675821019 +oxidoreductase 19 43 2.200235545010611 0.0277901876297073 12.558252427184469 43.60436893203884 0.9664652969079414 0.3656199292680728 5.072676172192643 3.8442089013841825 1.3118377214144643 0.3470065139863294 8.030059444080965e-05 0.0100117815079471 0.002167548947337 0.007976907507528 0.0001834862218712 +tubulin 5 7 2.0895229346523223 0.0366606756361753 3.6140776699029127 5.883495145631068 0.537603280896448 0.3771225437200781 1.6631634011190108 1.117390952728082 1.2199662970774952 0.3090115161057067 0.000508394757649 1.0 1.0 0.3559534457378639 0.0013369974246366 +calmodulin-related 8 14 2.0713850726550107 0.0383228247546751 5.053398058252427 12.385922330097088 1.3935892727836532 0.1814075830019033 2.0222219603900085 1.786979844553702 1.206053991839631 0.2252292235861566 0.0003294901345179 0.0060764540616979 0.0016986126979642 0.0215683584236732 0.0010205277760807 +phosphatase 5 16 2.0216459149252 0.0432129450386331 3.5849514563106797 16.065533980582526 -0.9938490068264416 0.2953388308351354 2.1722134806253504 2.590699657402366 1.0537282297009678 0.2539607611250225 0.0499393888632567 0.0406061543885706 0.0275216398495969 0.0814773755217055 0.1114390039799233 diff --git a/panther_protein_class/metrics.json b/panther_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..774bf2c3c8b831d628f6dbce8e4c3331635d8635 --- /dev/null +++ b/panther_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3120, + "annotations_size": 159, + "title": "Average number of proteins per term", + "value": 13.377358490566039 +} \ No newline at end of file diff --git a/panther_protein_class/paths.json b/panther_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..63f3adb4bd3c53773cfddf4132dedcb590dd0b76 --- /dev/null +++ b/panther_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/panther_protein_class/fragment/C390/C390_val_log2fc"} \ No newline at end of file diff --git a/panther_protein_class/result.tsv b/panther_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..3a10d352ab3345f13c9b04a2e7121e90c6efe0e4 --- /dev/null +++ b/panther_protein_class/result.tsv @@ -0,0 +1,45 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +primary active transporter 0.7545881385186749 3.62872010008582 0.0002848298523614 0.0442839199446262 0.022643973262735 24 Q8N4H5,O75381,Q9H9B4,P20020,Q04656,Q9NS69,P05026,P16615,P98194,Q96NB2,P23634,Q96B49,P05023,P35670,O60888,Q15388,Q6P4A7,Q15758,Q9BUN8,O96008 20 +oxidase 0.7643245830882548 3.0055590925146207 0.0026509308076174 0.344303774873909 0.1053744996027944 15 P13073,P20674,Q6ZRP7,P14406,Q15800,O75880,O43819,O75845 8 +ATP synthase 0.6715500698971368 2.9255853288991447 0.0034380887501304 0.421662688640237 0.109331222254147 20 Q9Y487,P24539,P56385,Q93050,Q96IX5,P00846,O75964,Q15904 8 +membrane trafficking regulatory protein 0.6939788018863307 2.861732038909796 0.0042133296084203 0.4889739339082164 0.1116532346231395 18 Q14108,Q8WTV0,P13473,Q9P253,O43760,P11279,P24390 7 +secondary carrier transporter 0.7215723065643574 2.6558221896723264 0.0079115317644955 0.7171775726768908 0.1279064430935211 14 Q9H936,Q9BQT8,O75746,Q8TB61,Q15043,Q02978,Q9Y6M7,Q9UBX3,Q9UJS0,P55011,O95202 11 +metalloprotease 0.590254867269189 2.650199288898807 0.0080444303832403 0.7231382130785542 0.1279064430935211 27 Q96E52,Q9NZ08,P22695,P55786,Q10713,Q9UIQ6,O75844,Q5JRX3,P42892 9 +oxygenase 0.8580644195743545 2.51849607412029 0.0117857197388711 0.8481800168280091 0.1527058710209058 7 P30519,Q6UW02,Q16850,P09601 4 +transfer/carrier protein 0.7254188495841208 2.486452436801066 0.0129023815466333 0.8731599070848393 0.1527058710209058 12 P12236,P12235,P17900,Q9Y5M8,O15127,O15126,Q9NZD2,O14828 8 +acyltransferase 0.6211896261008671 2.400751031997882 0.016361464132359 0.92741447602143 0.1527058710209058 18 Q8NCC3,P23786,Q9BWD1,P50416 4 +mitochondrial carrier protein 0.8588398645117544 2.3940354351014377 0.016664138763941 0.9308808231677584 0.1527058710209058 6 Q70HW3,Q9HC21,Q9Y6C9,Q9NZJ7 4 +glycosyltransferase 0.5840744522539235 2.337655114084335 0.0194051464042102 0.9556546658857514 0.1542709139134711 20 Q10472,Q9BT22,P04843,Q8NBN7,Q9H6U8,P46977,Q9BV10,Q96L58 8 +transmembrane signal receptor 0.8368657675015908 2.297208429925046 0.0216068824691639 0.9689809242935796 0.1555583613607762 6 Q99720,Q9UMX5,Q96GC9,O75787,O00264 5 +ATP-binding cassette (ABC) transporter 0.866838564716671 2.287778639051394 0.0221504154081104 0.9716040213894702 0.1555583613607762 5 O75027 1 +SNARE protein 0.6726468332630323 2.281783034488616 0.0225021529012443 0.9731827822252136 0.1555583613607762 13 O15400,Q9P2W9,O60499,O95249,O95721,O43752,Q13190 7 +serine protease 0.6044248310393133 2.2080035337635913 0.0272440268297879 0.9876228374634488 0.1586583273150464 17 O14773,Q9H3G5,P42785,Q9HB40,P10619 5 +oxidoreductase 0.4839268690831902 2.200235545010611 0.0277901876297073 0.9886801673886436 0.1586583273150464 43 Q8N0U8,Q16134,O14949,O43169,O95169,Q86Y39,P16435,O96000,Q8N4Q0,O75306,O95831,Q9Y6M9,Q9NX14,P00403,P09622,Q96HE7,O95168,Q9Y320,Q15067 19 +tubulin 0.7644139892546106 2.0895229346523223 0.0366606756361753 0.9973642334607292 0.1904165354997923 7 Q13885,Q9BVA1,P07437,Q9BUF5,P68371 5 +calmodulin-related 0.6214317511900413 2.0713850726550107 0.0383228247546751 0.9979970963917938 0.1904165354997923 14 Q9BPX6,P80303,Q02818,Q9BRK5,P41208,O43852,Q14257,Q8IYU8 8 +phosphatase 0.5872432478666012 2.0216459149252 0.0432129450386331 0.9991095055049836 0.2020840665041962 16 P11117,Q9H773,P36639,Q9NPH0,Q9NX62 5 +lipase 0.8693838254171945 1.978658013637306 0.0478545231756069 0.99958901490442 0.2037512426756376 4 Q8NCG7,Q9H6V9,P38571 3 +amino acid transporter 0.7561086817927167 1.800949178688114 0.0717108905929442 0.9999927282723264 0.2850507901069533 5 O14925,P30825,O60831 3 +voltage-gated ion channel 0.9865255052935508 1.7821946048425896 0.0747175023142978 0.999995658685804 0.285823984427371 3 P21796,Q9Y277 2 +transferase 0.4568024489712216 1.7152838375814696 0.0862932003390657 0.999999413469983 0.3021193208876275 30 O43505,Q7LGA3,Q9BVG9,Q8NCH0,P37268,Q11206 6 +glycosidase 0.8058408215660937 1.7120873117821804 0.0868805792752638 0.9999994704765824 0.3021193208876275 4 P04066,Q9BTY2,P06865 3 +esterase 0.6851413250590408 1.709244928699058 0.0874055896907601 0.9999995167510776 0.3021193208876275 7 Q969T7 1 +galactosidase 0.949005772931366 1.5868262949887892 0.1125519916553221 0.9999999943150828 0.3376559749659664 2 P16278 1 +phospholipase 0.6214251495450994 1.5495810320069476 0.1212421085203905 0.999999998810926 0.3560733982268461 8 Q8IV08,Q8NHP8 2 +membrane traffic protein 0.3648593816754048 1.4797133919189422 0.1389497501629155 0.9999999999532768 0.3780585881234014 66 Q96PC5,Q9NX40,Q9UI14,Q709C8,Q5JRA6,Q9Y3E7,P43307,Q9H4M9,Q96D71,P40855,Q12907,Q00765,P49257,Q9H6H4,Q9UQN3,Q9HD42,P11717,O60313,P51572,P20645,P78537,O43493,A6NIH7 23 +nucleic acid metabolism protein 0.6591535972743288 1.4747272338682096 0.1402858911904445 0.9999999999635 0.3780585881234014 6 Q9NYF8,Q9Y2W1,Q9Y580,Q9UGR2 4 +phosphodiesterase 0.6731146538867235 1.421436123328838 0.1551900111316249 0.999999999997737 0.4112535294988059 5 O43924 1 +transporter 0.3755881091938538 1.355519617960439 0.1752520625338862 0.9999999999999504 0.4286935068136602 55 Q9NR77,P41440,O43772,Q8NFH4,Q9C0E2,Q99805,O43681,Q9H2D1,Q567V2,Q9HD45,Q15070,Q7Z3B4,Q8N1F7,O43615,O60830,P52292 16 +kinase 0.4638455827264269 1.3139675321084716 0.1888571306483888 0.9999999999999964 0.4308395760305142 18 Q8WVC6,P35790,Q9BRR6,Q53H12 4 +G-protein coupled receptor 0.8648822001141626 1.307856079842763 0.1909221287675802 0.9999999999999976 0.4308395760305142 3 Q8NBN3 1 +cell adhesion molecule 0.8806927517639563 1.3035487523015812 0.1923874836362673 0.9999999999999982 0.4308395760305142 2 Q08722 1 +protein modifying enzyme 0.3966735791377533 1.0569623852243042 0.2905287546394295 1.0 0.5376766813777173 26 Q9UMR5,P50897,O60725,Q92791,P13674,Q86YN1 6 +major histocompatibility complex protein 0.7641963426371582 0.9183484135225084 0.3584364887148501 1.0 0.6193428791892647 3 P10321,P04439 2 +viral or transposable element protein 0.7790250160359448 0.8911878157782039 0.3728284198464 1.0 0.6306353059104001 2 Q9NUD5 1 +lyase 0.4228086357969683 0.749049760947715 0.4538272137472894 1.0 0.7363114998552961 13 Q9UHG3 1 +protein-binding activity modulator 0.5404364569961536 0.5870444852605068 0.5571738303118108 1.0 0.7771108685927888 4 P14314,O14737,Q9UNZ2 3 +dehydrogenase 0.2890746746721828 0.517841418946587 0.6045689172826014 1.0 0.8001803064913868 66 Q13423,Q3SXM5,P51648,P30837,Q9P0J0,Q96CU9,P21912,Q02127 8 +chaperone 0.2896054887394667 0.5115839141253452 0.6089422458204894 1.0 0.8001803064913868 67 P27824,Q96I36,Q9NWM8,Q15006,O14657,Q9Y2G8,P46379,Q9Y6N1,Q9Y2R0,O95433,Q7KZN9,O15260,Q96KC8 13 +dehydratase 0.6507376523412607 0.4313426359356607 0.6662192534617777 1.0 0.8407052484160528 2 Q15738 1 +Hsp90 family chaperone 0.4082156611039822 0.1525943600492813 0.8787181729390967 1.0 0.9376925469618548 4 P07900,P14625,Q12931 3 +cyclase 0.5109044259140401 0.1133560235290582 0.90974830306103 1.0 0.9516446064914722 2 P48449 1 diff --git a/panther_protein_class/selections.json b/panther_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..17bce0093442d44ab9eb1ae4ff86bb76f569e57e --- /dev/null +++ b/panther_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthase", "ATP-binding cassette (ABC) transporter", "C2H2 zinc finger transcription factor", "DNA glycosylase", "DNA helicase", "DNA ligase", "DNA metabolism protein", "DNA methyltransferase", "DNA polymerase processivity factor", "DNA topoisomerase", "DNA-binding transcription factor", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "G-protein", "G-protein coupled receptor", "G-protein modulator", "GTPase-activating protein", "Hsp90 family chaperone", "P53-like transcription factor", "RNA helicase", "RNA metabolism protein", "RNA methyltransferase", "RNA processing factor", "RNA splicing factor", "SNARE protein", "acetyltransferase", "actin and actin related protein", "actin binding motor protein", "actin or actin-binding cytoskeletal protein", "acyltransferase", "aldolase", "amino acid kinase", "amino acid transporter", "aminoacyl-tRNA synthetase", "antimicrobial response protein", "aspartic protease", "basic helix-loop-helix transcription factor", "basic leucine zipper transcription factor", "cadherin", "calcium-binding protein", "calmodulin-related", "carbohydrate kinase", "cell adhesion molecule", "centromere DNA-binding protein", "chaperone", "chaperonin", "chromatin/chromatin-binding, or -regulatory protein", "cyclase", "cysteine protease", "cytokine", "cytoskeletal protein", "damaged DNA-binding protein", "deaminase", "decarboxylase", "defense/immunity protein", "dehydratase", "dehydrogenase", "endodeoxyribonuclease", "endoribonuclease", "epimerase/racemase", "esterase", "exodeoxyribonuclease", "exoribonuclease", "extracellular matrix glycoprotein", "extracellular matrix protein", "extracellular matrix structural protein", "galactosidase", "general transcription factor", "glucosidase", "glycosidase", "glycosyltransferase", "growth factor", "guanyl-nucleotide exchange factor", "heterotrimeric G-protein", "histone", "histone modifying enzyme", "homeodomain transcription factor", "hydratase", "hydrolase", "hydroxylase", "immunoglobulin receptor superfamily", "immunoglobulin superfamily cell adhesion molecule", "integrin", "intercellular signal molecule", "intermediate filament binding protein", "ion channel", "isomerase", "kinase", "kinase activator", "kinase inhibitor", "kinase modulator", "ligase", "lipase", "lyase", "mRNA capping factor", "mRNA polyadenylation factor", "major histocompatibility complex protein", "membrane traffic protein", "membrane trafficking regulatory protein", "metalloprotease", "methyltransferase", "microtubule binding motor protein", "microtubule or microtubule-binding cytoskeletal protein", "mitochondrial carrier protein", "mutase", "non-motor actin binding protein", "non-motor microtubule binding protein", "non-receptor serine/threonine protein kinase", "nucleic acid metabolism protein", "nucleotide kinase", "nucleotide phosphatase", "nucleotidyltransferase", "oxidase", "oxidoreductase", "oxygenase", "peptide hormone", "peroxidase", "phosphatase", "phosphatase activator", "phosphatase modulator", "phosphodiesterase", "phospholipase", "primary active transporter", "primase", "protease", "protease inhibitor", "protein modifying enzyme", "protein phosphatase", "protein-binding activity modulator", "pyrophosphatase", "reductase", "replication origin binding protein", "ribosomal protein", "scaffold/adaptor protein", "secondary carrier transporter", "serine protease", "small GTPase", "storage protein", "structural protein", "tight junction", "transaminase", "transcription cofactor", "transfer/carrier protein", "transferase", "transketolase", "translation elongation factor", "translation factor", "translation initiation factor", "translation release factor", "translational protein", "transmembrane signal receptor", "transporter", "tubulin", "tyrosine protein kinase receptor", "ubiquitin-protein ligase", "vesicle coat protein", "viral or transposable element protein", "voltage-gated ion channel", "zinc finger transcription factor"], "available_proteins": ["AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ACAA1", "ACAA2", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTR10", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGPAT1", "AGPAT5", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AKAP1", "AKAP12", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALG9", "ALKBH5", "ALYREF", "ANAPC1", "ANAPC7", "ANKFY1", "ANKHD1", "ANLN", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "APRT", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARG2", "ARHGDIA", "ARHGEF7", "ARID4B", "ARIH1", "ARIH2", "ARL1", "ARL6", "ARL6IP5", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC3", "ASF1A", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD2", "ATG3", "ATG4B", "ATL2", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1H", "ATP7A", "ATP7B", "ATPAF1", "ATPIF1", "ATXN2", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BAG2", "BAG6", "BAIAP2", "BCAP31", "BCAS2", "BCKDK", "BCLAF1", "BLMH", "BLOC1S1", "BLVRA", "BLVRB", "BOP1", "BPHL", "BPNT1", "BRCA1", "BRD1", "BRD7", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BZW1", "BZW2", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CBR1", "CCAR1", "CCAR2", "CCDC12", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD276", "CD2BP2", "CD3EAP", "CD47", "CDC23", "CDC27", "CDC37", "CDC42", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK16", "CDK2", "CDK4", "CDK5", "CDK7", "CDK9", "CDKN2AIP", "CDS2", "CEBPZ", "CEP170", "CETN2", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHEK2", "CHERP", "CHKA", "CHMP1A", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT3", "CNOT7", "CNP", "COA3", "COASY", "COG4", "COIL", "COLEC12", "COLGALT1", "COMT", "COMTD1", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX11", "COX14", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX7A2", "COX7A2L", "COX7C", "CPD", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CS", "CSE1L", "CSNK1A1", "CSNK1E", "CSNK2B", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CYB5B", "CYB5R1", "CYB5R3", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAG1", "DAGLB", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DBT", "DCAF13", "DCAKD", "DCP1B", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DEGS1", "DEK", "DENR", "DERL1", "DGCR8", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIDO1", "DIEXF", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLGAP5", "DLST", "DMAP1", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC21", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK1", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUS2", "DUSP12", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC4", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF2", "EEFSEC", "EFHD2", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHHADH", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOB", "ELOC", "ELP1", "ELP3", "EMC2", "EMG1", "ENAH", "ENO1", "ENO2", "EPHA7", "EPHX1", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC3", "ERH", "ERMP1", "ERO1A", "ERP29", "ESD", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC4", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOSC1", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "FAHD1", "FAM3C", "FAM98A", "FAM98B", "FARSA", "FARSB", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FKBP14", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FLAD1", "FLII", "FNDC3A", "FNTA", "FNTB", "FOXRED1", "FRG1", "FSCN1", "FTL", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATAD2B", "GATB", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLC", "GCN1", "GDE1", "GDI1", "GDI2", "GDPD1", "GFPT1", "GGH", "GINS1", "GINS2", "GIPC1", "GLA", "GLB1", "GLDC", "GLMN", "GLO1", "GLRX3", "GLRX5", "GLS", "GLTP", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAO1", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLT1B", "GOSR1", "GOSR2", "GOT1", "GOT2", "GPAT4", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR89B", "GPRASP2", "GPT2", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2H4", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GUF1", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADHB", "HARS2", "HAT1", "HBS1L", "HCCS", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HECTD1", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HM13", "HMBS", "HMGA1", "HMGCL", "HMGCR", "HMGN1", "HMOX1", "HMOX2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HTATSF1", "HTRA2", "HUS1", "HUWE1", "IARS", "IARS2", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMP3", "IMPAD1", "IMPDH1", "IMPDH2", "INTS11", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "IRF2BPL", "ISCU", "ISOC1", "ISYNA1", "ITGAV", "ITGB1", "ITPA", "IVD", "KARS", "KAT7", "KCTD12", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0368", "KIF11", "KIF14", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KLC1", "KLC4", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRR1", "KYAT3", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LBR", "LCLAT1", "LCMT2", "LDAH", "LDB1", "LDHA", "LDHB", "LENG8", "LETM1", "LGALS3", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LRPAP1", "LRRC40", "LRRC47", "LRRC59", "LRRC8C", "LRWD1", "LSM14B", "LSM2", "LSM4", "LSM6", "LSS", "LYAR", "LYPLA1", "LYPLA2", "LZTFL1", "M6PR", "MACF1", "MAGED2", "MAGT1", "MAN1A1", "MAN1A2", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP3K7", "MAP7D1", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARCH5", "MARK2", "MARS", "MAT2A", "MAT2B", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED23", "MED24", "MED4", "METAP2", "METTL1", "METTL13", "METTL3", "MFAP1", "MFSD5", "MGEA5", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINPP1", "MIPEP", "MMAB", "MMS19", "MOGS", "MORF4L1", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL27", "MRPL3", "MRPL33", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS17", "MRPS2", "MRPS21", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTHFS", "MTOR", "MTPAP", "MUT", "MVD", "MYBBP1A", "MYCBP", "MYCBP2", "MYDGF", "MYEF2", "MYG1", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA50", "NAE1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NASP", "NAT10", "NAXE", "NBN", "NCAPD2", "NCBP1", "NCDN", "NCKIPSD", "NCOA5", "NCOR1", "ND5", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFB10", "NDUFB11", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS5", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEDD4L", "NENF", "NF1", "NFRKB", "NFS1", "NFXL1", "NHP2", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOC4L", "NOL6", "NOL9", "NOM1", "NONO", "NOP10", "NOP14", "NOP56", "NOP58", "NOP9", "NPEPPS", "NPM1", "NRBP1", "NRDC", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDCD3", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUMA1", "NUP107", "NUP153", "NUP155", "NUP160", "NUP210", "NUP214", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "OGDH", "OGT", "OLA1", "OMA1", "OPA1", "ORC2", "ORC3", "ORC5", "OSGEP", "OTUB1", "OXA1L", "OXCT1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B2", "PAFAH1B3", "PAK1IP1", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PARL", "PARN", "PARP1", "PARP2", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PCYOX1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PEPD", "PES1", "PEX14", "PEX19", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PHAX", "PHC2", "PHF10", "PHF3", "PHF6", "PHGDH", "PI4K2A", "PI4KA", "PICALM", "PIK3C2A", "PIK3R2", "PINX1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNP", "PNPLA6", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLD2", "POLDIP3", "POLE", "POLE2", "POLE4", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR2L", "POLR3A", "POLR3C", "POLR3E", "POLRMT", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R14B", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSMG1", "PSMG3", "PSPC1", "PSPH", "PTCD1", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PUF60", "PUM1", "PURA", "PUS1", "PWP1", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB3GAP1", "RAB3GAP2", "RABAC1", "RABGAP1", "RABGEF1", "RABGGTA", "RABL6", "RAC1", "RACGAP1", "RAD23A", "RAD23B", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANGAP1", "RAP2B", "RAPGEF2", "RARS", "RASA1", "RAVER1", "RBBP6", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM34", "RBM4", "RBM47", "RBM7", "RBPJ", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REPS1", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT2", "RIDA", "RIF1", "RIOK2", "RIPK1", "RNASEH2A", "RNF2", "RNMT", "RNPS1", "ROCK1", "ROCK2", "RPA1", "RPF1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS27", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP7A", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCA", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAMHD1", "SAP18", "SAP30BP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SC5D", "SCAF1", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCYL2", "SDCBP", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC13", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SHMT1", "SHMT2", "SHOC2", "SIGMAR1", "SIN3A", "SIN3B", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC30A9", "SLC35B2", "SLC38A1", "SLC39A14", "SLC44A1", "SLC4A1AP", "SLC4A7", "SLC7A1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC6", "SMG5", "SMN1*", "SMNDC1", "SMPD4", "SNAP23", "SNAP29", "SNIP1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX2", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPCS2", "SPCS3", "SPDL1", "SPEN", "SPR", "SPTLC1", "SPTLC2", "SQLE", "SREK1", "SRFBP1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "ST3GAL4", "STAG1", "STAG2", "STAM", "STAMBP", "STAT1", "STAT3", "STK38", "STK4", "STOML2", "STRAP", "STRBP", "STT3A", "STT3B", "STUB1", "STX10", "STX12", "STX18", "STX4", "STX5", "STX6", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", 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"VPS16", "VPS18", "VPS25", "VPS26A", "VPS26B", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4A", "VPS4B", "VPS53", "VRK1", "VRK3", "WARS", "WARS2", "WDR1", "WDR4", "WDR74", "WDR82", "WIZ", "XAB2", "XPA", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YLPM1", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H15", "ZC3H4", "ZC3H7B", "ZCCHC3", "ZCCHC8", "ZFR", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZNF207", "ZNF281", "ZNF326", "ZNF598", "ZW10", "ZYX", "ZZZ3"], "leading_proteins": ["ABCB7", "ACAT2", "ACOX1", "ACP2", "ACP6", "ADPGK", "AGK", "AHSA1", "AIFM1", "ALDH1B1", "ALDH3A2", "ALG1", "ALG12", "ALG9", "ASNA1", "ATP1A1", "ATP1B1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5F1", "ATP5I", "ATP5L", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP7A", "ATP7B", "B3GALT6", "B4GAT1", "BAG6", "BCAP31", "BCLAF1", "BLOC1S1", "CALU", "CANX", "CD47", "CETN2", "CHKA", "CHMP1A", "CHMP2B", 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0000000000000000000000000000000000000000..f85b5bd7e3b5b236b3c51ba67951dd81c3673a8e --- /dev/null +++ b/pharos_dto/basic/plot_9.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:2ad4ae88fd449a29a34faf7dbcbd67efc7c2fea6bfa9d28408f5af5456167937 +size 133635 diff --git a/pharos_dto/consensus.joblib b/pharos_dto/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..2c2d867a9604956adc65f44554fb710cedcf48fc --- /dev/null +++ b/pharos_dto/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:9f2f7aa5673bb0569085d45607cb2b47a5bc9438c4d9f9671fbdfa4eb172c398 +size 262850 diff --git a/pharos_dto/df_merge.tsv b/pharos_dto/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..ca57c5df2c941dc3cf2bf182c42c97f9fd622c1c --- /dev/null +++ b/pharos_dto/df_merge.tsv @@ -0,0 +1,21 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +SLC superfamily of solute carriers 32 44 4.003402887552659 6.243783778292489e-05 18.888349514563107 44.33009708737864 2.1618907004737498 0.1690913715307362 9.633686860107934 5.825351940723624 1.7350998035598977 0.2760301582542676 0.0007968091577016 0.5796059904208676 0.2548852757682844 0.0322368813739424 0.0032040487127878 +SLC25 family of mitochondrial transporters 16 19 3.202275118127538 0.0013634671142808 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 1.039388470909135e-06 0.1604648724397155 0.048990890514732 0.001820540651884 8.556622581523825e-07 +Oxidase 9 21 2.9664644437250445 0.0030124519136027 6.703883495145631 19.237864077669904 1.0247065178117305 0.263154064152295 3.1321515397534676 1.9967748999180144 1.3264616190823058 0.2799417791483025 3.3563825602883177e-06 0.0104419310742173 0.0038117145357013 0.0010720436073174 2.2380734395490096e-06 +Calcium-binding protein 6 20 2.426606183371407 0.0152407896657773 6.135922330097087 18.021844660194176 1.3650952896045327 0.2072953623045914 2.3371152398743247 2.2037057261181348 1.237653756718734 0.2545563939054063 0.0019328992996702 0.0012896191141567 0.0009611330378982 0.0244406528674846 0.0062896490617296 +Membrane trafficking regulatory protein 6 20 2.384015302258511 0.0171248902707106 4.560679611650485 20.218446601941743 0.5159227056829229 0.4386866271320015 2.6094874555832708 2.7661001804550924 1.1256129588723178 0.3307884378613797 0.0087139040293847 1.0 0.3593428278464597 0.0244406528674846 0.0062896490617296 +P-type ATPases 6 9 2.359688041949361 0.0182903085648649 3.2815533980582523 6.757281553398058 0.5021561418998097 0.3946150755400491 1.82441625577419 1.518277124105495 1.19746001211325 0.3286800838620415 0.0001534060119501 1.0 1.0 0.097689242801984 5.493155547881244e-05 +Metalloprotease 13 37 2.3348590840441203 0.0195507834196491 10.080097087378642 37.81310679611651 1.0846602244748076 0.3802793741361127 4.2814674000125414 2.184793664748831 0.9789887795730944 0.3416347995760264 0.0021128797321802 1.0 0.033011066423499 0.0018365459096632 0.0026289561565188 +Receptor 14 27 2.321969729126231 0.0202345656423779 8.25242718446602 27.344660194174757 1.739519175745715 0.1905542238199536 2.855648283399814 4.245230977176689 1.1861053756197322 0.2707159726336181 0.0028873223172531 0.0887403761234401 0.271213554068588 0.1131258580916301 0.0136443970185141 +Mitochondrial nucleotide transporter subfamily 7 8 2.288312074375652 0.022119353857031 4.216019417475728 9.065533980582524 1.5870110662923598 0.1668197633609344 2.720728714423222 1.1029864386277723 1.1616247375257451 0.2431804664231326 0.0022568934045067 0.0683810764565047 0.1349531130589082 0.0495157384890535 0.0048822579474643 +SNARE protein 7 13 2.281783034488616 0.0225021529012443 4.555825242718447 10.6626213592233 0.9494792984446184 0.3117420251981136 2.5225757464631977 2.583604188764985 1.1633177546874711 0.3031193116521645 0.0035816188869452 0.1197698958477507 0.0021303683071518 0.0004102788019959 0.0015706126808535 +F-type and V-type ATPases 5 15 2.280141344799801 0.0225993067850569 4.995145631067961 15.616504854368932 0.6819760311565471 0.3553057475304781 2.5561606009064737 1.187932616128487 1.149561543758102 0.2999604229905949 0.0016982309129601 0.1029565435856987 0.0013262573806951 0.0020400745925255 0.0006318501388434 +Glycosyltransferase 6 16 2.2467714215155263 0.0246546390736606 5.713592233009709 16.264563106796118 0.58827010515732 0.444796659838118 2.8207810163966904 2.842193627279741 1.1276277753027448 0.3350616775048655 0.036400957919905 1.0 1.0 0.1942870876140905 0.0322356046235818 +Signaling 8 16 2.213875306761614 0.0268373578308123 5.66747572815534 18.009708737864077 1.330299096012152 0.2668377480945127 2.507969905227609 1.6994867622232877 1.0107551340834326 0.2926688105318188 0.2629971455013634 1.0 1.0 0.1629443488297355 0.4256782528579432 +Transporter 98 185 2.195325651174189 0.0281402461406528 57.59466019417476 188.27912621359224 1.4971900036635353 0.4160578104205245 21.77919356765414 18.57070590158326 1.926868489654782 0.421013047757716 7.901437220534905e-13 0.4053344673738789 0.002412408312648 5.808021029463751e-09 5.223496976454816e-13 +Serine protease 4 25 2.1707929024704056 0.0299468307036983 5.475728155339806 28.060679611650485 -0.0299555241091654 0.3004695585307199 2.9431330647424168 1.972802334926414 1.5768370330864625 0.2828311561719579 0.0254819223534938 0.0303491574999332 0.0002266749410996 0.0127222619547071 0.0611543838186325 +F-type ATPase 3 8 2.097535774021838 0.0359461737952675 3.174757281553398 7.754854368932039 0.3978961134348252 0.300656405601223 2.006916121747128 0.8649601417133376 1.341428125637103 0.2766885427231999 0.0078154121226846 0.0506073598520519 0.0047533286028597 0.0276231155809849 0.0013781701696679 +Tubulin 5 7 2.0895229346523223 0.0366606756361753 3.6140776699029127 5.883495145631068 0.537603280896448 0.3771225437200781 1.6631634011190108 1.117390952728082 1.2199662970774952 0.3090115161057067 0.000508394757649 1.0 1.0 0.3559534457378639 0.0013369974246366 +Intracellular calcium-sensing protein 5 16 2.03995638467138 0.0413546700197866 5.330097087378641 14.50728155339806 1.3338669185027796 0.2094989649985028 2.1356354617596836 1.8597539737980884 1.176586593960994 0.2465515447823433 0.0013364321079933 0.0098384095742339 0.0034893000144238 0.0411512789917762 0.003914644875648 +Calmodulin 5 16 2.03995638467138 0.0413546700197866 5.330097087378641 14.50728155339806 1.3338669185027796 0.2094989649985028 2.1356354617596836 1.8597539737980884 1.176586593960994 0.2465515447823433 0.0013364321079933 0.0098384095742339 0.0034893000144238 0.0411512789917762 0.003914644875648 +Esterase 2 11 2.0028871428990267 0.0451894034200408 2.4199029126213594 10.856796116504857 0.6548503739556798 0.3454832165784889 1.4749994208625692 1.2546524785480109 1.099568757577031 0.2732488393636652 0.0229393586787355 0.0727733471903131 0.0100519320580488 0.0061570039439817 0.0397387250697101 diff --git a/pharos_dto/metrics.json b/pharos_dto/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..53eb3bef695f69cce9f75d1d961294354d3d0bd2 --- /dev/null +++ b/pharos_dto/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3120, + "annotations_size": 1989, + "title": "Average number of proteins per term", + "value": 3.1327300150829562 +} \ No newline at end of file diff --git a/pharos_dto/paths.json b/pharos_dto/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..36bfef316e96b27b94ee077c96f1141aea19d7fe --- /dev/null +++ b/pharos_dto/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_dto/fragment/C390/C390_val_log2fc"} \ No newline at end of file diff --git a/pharos_dto/result.tsv b/pharos_dto/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..186619ee123ec684b05c5ecf453fb18828a7afd0 --- /dev/null +++ b/pharos_dto/result.tsv @@ -0,0 +1,61 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +SLC superfamily of solute carriers 0.6946261773527883 4.003402887552659 6.243783778292489e-05 0.1167904022966939 0.1009581785133154 44 Q9H936,P41440,Q6NUK1,Q9H9B4,Q9H2D1,Q02978,P55011,O43808,O95202,O43772,P08195,Q70HW3,O75746,Q9BQT8,Q96NB2,Q8IXU6,Q8TAD4,Q9UJS0,Q9NY64,Q9H0U3,P12235,Q8TB61,P30825,Q15043,Q9UBX3,Q9NZJ7,P05141,P12236,Q9Y6C9,Q15758,Q9HC21,Q9Y6M7 32 +SLC25 family of mitochondrial transporters 0.7329135042392056 3.202275118127538 0.0013634671142808 0.9337146645086316 0.1848398671377504 19 P12236,Q9H936,O43772,Q6NUK1,P12235,Q9Y6C9,Q70HW3,O75746,Q9BQT8,Q9H2D1,Q9HC21,Q9UBX3,Q9UJS0,O43808,P05141,Q9NZJ7 16 +Oxidase 0.6721992232132067 2.9664644437250445 0.0030124519136027 0.9975232547421986 0.1848398671377504 21 P20674,P14406,Q15800,O75880,O43819,O43169,O15260,Q15067,O75845 9 +Calcium-binding protein 0.5969186022680616 2.426606183371407 0.0152407896657773 0.9999999999999458 0.1848398671377504 20 P80303,Q02818,P43307,P41208,O43852,Q14257 6 +Membrane trafficking regulatory protein 0.5907518924882351 2.384015302258511 0.0171248902707106 0.9999999999999988 0.1848398671377504 20 O60749,P13473,Q9P253,O43760,P11279,P24390 6 +P-type ATPases 0.7615549406252458 2.3596880419493615 0.0182903085648649 1.0 0.1848398671377504 9 P16615,P98194,P20020,P05023,Q04656,P35670 6 +Metalloprotease 0.5101073561061656 2.3348590840441203 0.0195507834196491 1.0 0.1848398671377504 37 Q96E52,Q9NZ08,Q9Y4W6,Q8TAQ2,P22695,P55786,Q10713,Q8IYS1,P02786,Q9UIQ6,O75844,Q5JRX3,P42892 13 +Receptor 0.5469918668393574 2.321969729126231 0.0202345656423779 1.0 0.1848398671377504 27 Q9NR77,Q14108,Q8WTV0,O75381,Q567V2,P11717,Q9UQB8,Q9BUN8,Q14118,O75787,A6NIH7,P57105,P20645,Q13641 14 +Mitochondrial nucleotide transporter subfamily 0.767994858611813 2.288312074375652 0.022119353857031 1.0 0.1848398671377504 8 P12236,P12235,Q6NUK1,Q70HW3,Q9H2D1,Q9HC21,O43808 7 +SNARE protein 0.6726468332630323 2.281783034488616 0.0225021529012443 1.0 0.1848398671377504 13 O15400,Q9P2W9,O60499,O95249,O95721,O43752,Q13190 7 +F-type and V-type ATPases 0.6398844440350949 2.280141344799801 0.0225993067850569 1.0 0.1848398671377504 15 Q9Y487,P24539,Q93050,P56385,P00846 5 +Glycosyltransferase 0.6226445301634744 2.2467714215155263 0.0246546390736606 1.0 0.1848398671377504 16 Q10472,Q9BT22,Q9H6U8,Q8N128,P46977,Q9BV10 6 +Signaling 0.6174140511269501 2.213875306761614 0.0268373578308123 1.0 0.1860484379207875 16 Q8IZ81,Q5JRA6,Q96PC5,Q96GC9,P43490,Q99627,Q07820,O00264 8 +Transporter 0.5366891000870292 2.195325651174189 0.0281402461406528 1.0 0.1860484379207875 185 P41440,Q8NFH4,Q9H9B4,Q9H2D1,Q9P2W9,O43808,Q13190,P24539,Q7Z3B4,Q12846,Q8N1F7,P00846,P24390,Q9H0U3,P12235,P17900,P30825,Q15070,O60499,O95249,Q9UBX3,Q93050,P12236,Q92544,Q9BVK6,Q9Y487,O75027,O15400,Q15363,Q9UI14,P05026,O75947,P16615,P08195,Q70HW3,Q9HD45,Q96NB2,Q8TAD4,Q12907,Q9NZD2,Q7Z7H5,P49257,Q9NY64,P08183,O60749,Q99805,Q99567,Q8TB61,P05023,Q86Y82,O95721,O43760,P49755,Q9NZJ7,P05141,Q96EE3,Q9Y6C9,P13473,Q15758,O43493,P54709,Q9H936,Q9UPT5,Q02978,P11279,P55011,O95202,Q8WWI5,Q9UNK0,P98194,O43772,Q8TEM1,Q9BQT8,Q8IXU6,Q9UJS0,Q00765,Q15043,P51572,P35670,P56385,Q15388,Q9P253,Q9HC21,Q9Y3B3,P52292,Q6NUK1,P20020,Q04656,Q9Y3A6,Q9C0E2,O75746,P23634,O43752,Q9H6H4,P06576,O00560,O96008,Q9Y6M7 98 +Serine protease 0.5379761684904601 2.1707929024704056 0.0299468307036983 1.0 0.1860484379207875 25 O14773,Q9H3G5,Q9HB40,P42785 4 +F-type ATPase 0.7290032397830422 2.097535774021838 0.0359461737952675 1.0 0.1898132817750516 8 P56385,P24539,P00846 3 +Tubulin 0.7644139892546106 2.0895229346523223 0.0366606756361753 1.0 0.1913860468250729 7 Q13885,Q9BVA1,P07437,Q9BUF5,P68371 5 +Intracellular calcium-sensing protein 0.5900887897089347 2.03995638467138 0.0413546700197866 1.0 0.1961281875248805 16 P80303,Q02818,P41208,O43852,Q14257 5 +Calmodulin 0.5900887897089347 2.03995638467138 0.0413546700197866 1.0 0.1961281875248805 16 P80303,Q02818,P41208,O43852,Q14257 5 +Esterase 0.6519612721045487 2.0028871428990267 0.0451894034200408 1.0 0.2010776809898462 11 P50897,Q969T7 2 +Ca2+-ATPases 0.8620025673940899 1.9480008045903736 0.0514148668786345 1.0 0.2127886091545943 4 P20020,P16615,P98194 3 +Lipase 0.7408525049614918 1.7320154270973662 0.0832708157165424 1.0 0.2684370380230194 5 Q8NCC3,P38571 2 +Extracellular structure 0.6298749412298473 1.680237973942344 0.0929110236918782 1.0 0.2861099235677254 9 Q32P28,Q92791,P55081 3 +Oxygenase 0.7106621086782542 1.5944309363815428 0.1108395479664272 1.0 0.3144933821757829 5 Q16850 1 +ABCB subfamily 0.9387427838357932 1.544237510574375 0.1225308047565727 1.0 0.3312052717619766 2 O75027 1 +Phosphatase inhibitor 0.6675637038241431 1.5150809587433864 0.1297519030991485 1.0 0.3413710783918074 6 Q01105,P55209,Q99733 3 +Miscellaneous SLC25 mitochondrial transporters 0.927517639512508 1.4976433464721002 0.1342259384164819 1.0 0.3476537304462065 2 Q9NZJ7 1 +Mitochondrial amino acid transporter subfamily 0.7555867497279388 1.4975622850022436 0.134247011768501 1.0 0.3476537304462065 4 O43772,Q9UJS0 2 +Mitochondrial di- and tri-carboxylic acid transporter subfamily 0.752557278890211 1.4845486650677588 0.1376634226851871 1.0 0.349696740384211 4 Q9UBX3 1 +ATP-binding cassette transporter family 0.9054809490010516 1.4667231401015344 0.1424513853740832 1.0 0.3559495044083561 3 O75027 1 +Acyltransferase 0.5693498507728949 1.4372149437161368 0.150656928116551 1.0 0.3676768466549939 10 Q8NF37,Q9Y679,P14324,Q86UL3,P49354 5 +V-type ATPase 0.6279012498579788 1.425663666273069 0.1539654491423214 1.0 0.370428927034898 7 Q93050 1 +Protease 0.4014573638371526 1.411234227044205 0.1581755610555768 1.0 0.3749969928867436 107 O14773,Q5BJF2,Q9BXI6,Q9H300,Q92643,Q13510,P42785,Q9HB40,Q10713,Q9UIQ6,Q8NHP8,Q9H3G5,P22695,P55786,O75844,P10619,P42892,Q96E52,Q9NZ08,Q8TCT9,Q5JRX3 21 +SLC35 family of nucleotide sugar transporters 0.903143040410519 1.3965061774389955 0.1625621216728103 1.0 0.3795923761903462 2 Q8TB61 1 +Growth factor 0.6469223278814162 1.299824335059219 0.1936611829531398 1.0 0.4146308857844942 5 Q96PC5,Q5JRA6 2 +Aspartic protease 0.8596584750463669 1.2874282473525052 0.1979450639938211 1.0 0.4192893847536851 3 Q8TCT9 1 +Cu+-ATPases 0.8726747915330345 1.2704320630502226 0.2039307681959257 1.0 0.424286922533155 2 P35670 1 +Oxidoreductase 0.3975454755466465 1.2376768515366396 0.2158359057404302 1.0 0.4362780655667842 118 Q8N0U8,Q9H7Z7,Q16134,Q8TED1,Q9H9P8,Q9P0J0,Q9UDW1,Q02127,Q15392,O75880,O43169,O15260,P14406,O95169,P14927,Q14534,Q96CU9,P21912,P00374,P20674,Q9BY49,P30837,O95831,Q9Y6M9,Q9NX14,O43819,P00403,O75845,P09622,Q6ZRP7,Q13423,Q16850,Q15800,Q8N8N7,O95168,Q15067 36 +Phospholipase 0.6890837446566453 1.2107263211661117 0.2260003111633617 1.0 0.4480982495081463 4 Q8NCC3 1 +Storage 0.8232841565105836 1.0681531550430885 0.2854514317704673 1.0 0.5124213878984291 2 P40855 1 +Lyase 0.4111302651026762 1.0519097865534264 0.292840941422162 1.0 0.5191271234301963 20 Q96KA5,P22830 2 +Glycosidase 0.8053239255933463 0.9956984460629288 0.3193966853674606 1.0 0.5476605651657085 2 P06865 1 +Methyl-lysine/arginine binding protein 0.5734067873606854 0.9575431635811404 0.3382931709773962 1.0 0.5660018879581697 5 Q16637,Q13185,P45973 3 +Na+/K+-ATPases 0.7587423804940618 0.8977130072691674 0.3693385730990193 1.0 0.5932180681480883 3 P05026,P05023 2 +SLC56 Sideroflexins 0.7803078896728661 0.8962345388313405 0.3701275126052175 1.0 0.5932180681480883 2 Q9H9B4 1 +Reductase 0.4097547496719404 0.8644605880937923 0.3873349218489608 1.0 0.6109509592050619 17 P14927,Q9H7Z7,Q9UDW1,P00374,O95168 5 +PDHK family 0.710619185113891 0.7195343396595459 0.4718117518621465 1.0 0.6726828476098322 3 Q15118,Q15120 2 +Chromodomain 0.701636188642924 0.687239072367404 0.4919320861004332 1.0 0.6887657444864588 3 Q13185,P45973 2 +Phosphatase modulator 0.4553031656959655 0.6667148548715132 0.5049542883365241 1.0 0.6969840940328567 8 Q01105,Q99733 2 +Phosphatase 0.3322126415839534 0.5682628920216065 0.569856472086371 1.0 0.7417830647773507 29 P11117,Q9NPH0,Q9NX62 3 +SLC12 family of cation-coupled chloride transporters 0.6587556125721588 0.4565168720772241 0.6480183409932256 1.0 0.7806730185436204 2 P55011 1 +Hydrolase 0.3116504342112009 0.4075244027247744 0.6836228749875595 1.0 0.8012527391574872 98 P11117,Q9UMR5,Q9NVI7,P38571,P50897,Q9NPH0,P00813,O43924,P16278,Q9NX62,Q8NCC3,Q86YN1,P15586,P06865,Q969T7 15 +Acetyltransferase 0.3045329734918498 0.2549886625815251 0.7987318558182381 1.0 0.846580380257109 23 P23786,Q9BWD1,P50416 3 +MAPK family 0.5540583894770699 0.2351465793245906 0.8140949669977326 1.0 0.8527744027476472 3 Q16539,P27361 2 +PI3/PI4 kinase family 0.5468248877485502 0.1710290799895406 0.8642008999412889 1.0 0.8869430288871123 2 Q9BTU6 1 +Hsp90 family chaperone 0.4082156611039822 0.1525943600492813 0.8787181729390967 1.0 0.8958331347902939 4 P07900,P14625,Q12931 3 +CDK1 subfamily 0.5224502886465621 0.1300359974854208 0.8965379465966841 1.0 0.9130639916952406 2 P06493 1 +Ion channel 0.3458241981868579 0.0807724750912876 0.9356228982221292 1.0 0.9504361310336136 6 Q8NE86,P51790,Q4KMQ2 3 +Guanyl-nucleotide exchange factor 0.3536585365853782 0.043838243121141 0.9650333427705896 1.0 0.9758268016119483 4 Q9UJ41,Q14C86,Q9Y4G8 3 +TK group 0.4287006022453715 0.0332753281212976 0.973455028168854 1.0 0.9838425056035828 3 Q15375 1 diff --git a/pharos_dto/selections.json b/pharos_dto/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..4dcc24a9b44937cb372417490156d61f584347a9 --- /dev/null +++ b/pharos_dto/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1", "10 kDa heat shock protein, mitochondrial", "116 kDa U5 small nuclear ribonucleoprotein component", "14-3-3 protein beta/alpha", "14-3-3 protein epsilon", "14-3-3 protein eta", "14-3-3 protein gamma", "14-3-3 protein theta", "14-3-3 protein zeta/delta", "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "2',5'-phosphodiesterase 12", "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial", "2-hydroxyacyl-CoA lyase 1", "26S proteasome non-ATPase regulatory subunit 1", "26S proteasome non-ATPase regulatory subunit 12", "26S proteasome non-ATPase regulatory subunit 13", "26S proteasome non-ATPase regulatory subunit 14", "26S proteasome non-ATPase regulatory subunit 2", "26S proteasome non-ATPase regulatory subunit 3", "26S proteasome non-ATPase regulatory subunit 4", "26S proteasome non-ATPase regulatory subunit 7", "26S proteasome non-ATPase regulatory subunit 8", "26S proteasome regulatory subunit 10B", "26S proteasome regulatory subunit 4", "26S proteasome regulatory subunit 6A", "26S proteasome regulatory subunit 6B", "26S proteasome regulatory subunit 7", "26S proteasome regulatory subunit 8", "28S ribosomal protein S11, mitochondrial", "28S ribosomal protein S2, mitochondrial", "28S ribosomal protein S21, mitochondrial", "28S ribosomal protein S27, mitochondrial", "28S ribosomal protein S29, mitochondrial", "28S ribosomal protein S35, mitochondrial", "28S ribosomal protein S5, mitochondrial", "28S ribosomal protein S7, mitochondrial", "3'(2'),5'-bisphosphate nucleotidase 1", "3-hydroxyacyl-CoA dehydrogenase type-2", "3-hydroxyisobutyrate dehydrogenase, mitochondrial", "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial", "3-ketoacyl-CoA thiolase, mitochondrial", "3-ketoacyl-CoA thiolase, peroxisomal", "3-mercaptopyruvate sulfurtransferase", "39S ribosomal protein L1, mitochondrial", "39S ribosomal protein L11, mitochondrial", "39S ribosomal protein L12, mitochondrial", "39S ribosomal protein L13, mitochondrial", "39S ribosomal protein L14, mitochondrial", "39S ribosomal protein L19, mitochondrial", "39S ribosomal protein L2, mitochondrial", "39S ribosomal protein L20, mitochondrial", "39S ribosomal protein L21, mitochondrial", "39S ribosomal protein L22, mitochondrial", "39S ribosomal protein L27, mitochondrial", "39S ribosomal protein L38, mitochondrial", "39S ribosomal protein L39, mitochondrial", "39S ribosomal protein L41, mitochondrial", "39S ribosomal protein L43, mitochondrial", "39S ribosomal protein L44, mitochondrial", "39S ribosomal protein L47, mitochondrial", "39S ribosomal protein L48, mitochondrial", "39S ribosomal protein L49, mitochondrial", "39S ribosomal protein L9, mitochondrial", "4-trimethylaminobutyraldehyde dehydrogenase", "40S ribosomal protein S10", "40S ribosomal protein S11", "40S ribosomal protein S12", "40S ribosomal protein S13", "40S ribosomal protein S14", "40S ribosomal protein S15", "40S ribosomal protein S15a", "40S ribosomal protein S17", "40S ribosomal protein S18", "40S ribosomal protein S19", "40S ribosomal protein S2", "40S ribosomal protein S20", "40S ribosomal protein S21", "40S ribosomal protein S23", "40S ribosomal protein S24", "40S ribosomal protein S27", "40S ribosomal protein S28", "40S ribosomal protein S3", "40S ribosomal protein S3a", "40S ribosomal protein S4, X isoform", "40S ribosomal protein S5", "40S ribosomal protein S6", "40S ribosomal protein S7", "40S ribosomal protein S8", "40S ribosomal protein S9", "40S ribosomal protein SA", "45 kDa calcium-binding protein", "4F2 cell-surface antigen heavy chain", "5'-AMP-activated protein kinase catalytic subunit alpha-2", "5'-AMP-activated protein kinase subunit gamma-1", "5'-nucleotidase domain-containing protein 1", "5'-nucleotidase domain-containing protein 2", "5-formyltetrahydrofolate cyclo-ligase", "55 kDa erythrocyte membrane protein", "6-phosphogluconate dehydrogenase, decarboxylating", "6-phosphogluconolactonase", "60 kDa SS-A/Ro ribonucleoprotein", "60S ribosomal protein L10", "60S ribosomal protein L10a", "60S ribosomal protein L11", "60S ribosomal protein L12", "60S ribosomal protein L13", "60S ribosomal protein L13a", "60S ribosomal protein L14", "60S ribosomal protein L15", "60S ribosomal protein L18", "60S ribosomal protein L19", "60S ribosomal protein L21", "60S ribosomal protein L22", "60S ribosomal protein L23", "60S ribosomal protein L23a", "60S ribosomal protein L24", "60S ribosomal protein L26", "60S ribosomal protein L27", "60S ribosomal protein L27a", "60S ribosomal protein L28", "60S ribosomal protein L29", "60S ribosomal protein L3", "60S ribosomal protein L30", "60S ribosomal protein L31", "60S ribosomal protein L32", "60S ribosomal protein L35", "60S ribosomal protein L35a", "60S ribosomal protein L36", "60S ribosomal protein L36a", "60S ribosomal protein L37", "60S ribosomal protein L38", "60S ribosomal protein L5", "60S ribosomal protein L6", "60S ribosomal protein L7", "60S ribosomal protein L7-like 1", "60S ribosomal protein L7a", "60S ribosomal protein L8", "60S ribosomal protein L9", "7,8-dihydro-8-oxoguanine triphosphatase", "7-dehydrocholesterol reductase", "7-methylguanosine phosphate-specific 5'-nucleotidase", "A-kinase anchor protein 1, mitochondrial", "ABCB subfamily", "ABCD subfamily of peroxisomal ABC transporters", "ADP-dependent glucokinase", "ADP-ribose pyrophosphatase, mitochondrial", "ADP-sugar pyrophosphatase", "ADP/ATP translocase 1", "ADP/ATP translocase 2", "ADP/ATP translocase 3", "AFG3-like protein 2", "AGC group", "AH receptor-interacting protein", "AK1 subfamily", "AK2 subfamily", "AKT family", "AMPK subfamily", "AP-1 complex subunit beta-1", "AP-1 complex subunit gamma-1", "AP-1 complex subunit mu-1", "AP-2 complex subunit alpha-1", "AP-2 complex subunit alpha-2", "AP-2 complex subunit beta", "AP-2 complex subunit mu", "AP-2 complex subunit sigma", "AP-3 complex subunit beta-1", "AP-3 complex subunit delta-1", "AP-3 complex subunit mu-1", "AT-rich interactive domain-containing protein 4B", "ATP synthase F(0) complex subunit B1, mitochondrial", "ATP synthase mitochondrial F1 complex assembly factor 1", "ATP synthase subunit a", "ATP synthase subunit alpha, mitochondrial", "ATP synthase subunit beta, mitochondrial", "ATP synthase subunit d, mitochondrial", "ATP synthase subunit e, mitochondrial", "ATP synthase subunit f, mitochondrial", "ATP synthase subunit gamma, mitochondrial", "ATP-binding cassette sub-family B member 7, mitochondrial", "ATP-binding cassette sub-family D member 3", "ATP-binding cassette sub-family F member 1", "ATP-binding cassette sub-family F member 2", "ATP-binding cassette sub-family F member 3", "ATP-binding cassette transporter family", "ATP-citrate synthase", "ATP-dependent 6-phosphofructokinase, muscle type", "ATP-dependent 6-phosphofructokinase, platelet type", "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial", "ATP-dependent DNA helicase Q1", "ATP-dependent PFK group I subfamily", "ATP-dependent RNA helicase A", "ATP-dependent RNA helicase DHX29", "ATP-dependent RNA helicase DHX8", "ATP-dependent zinc metalloprotease YME1L1", "ATPase ASNA1", "ATPase family AAA domain-containing protein 2", "ATPase family AAA domain-containing protein 3A", "ATPase family AAA domain-containing protein 3B", "ATPase inhibitor, mitochondrial", "AUR family", "Acetolactate synthase-like protein", "Acetyl-CoA acetyltransferase, cytosolic", "Acetyl-CoA acetyltransferase, mitochondrial", "Acetyltransferase", "Acid ceramidase", "Acidic leucine-rich nuclear phosphoprotein 32 family member B", "Acidic leucine-rich nuclear phosphoprotein 32 family member E", "Aconitate hydratase, mitochondrial", "Actin and actin related protein", "Actin binding motor protein", "Actin family cytoskeletal protein", "Actin-like protein 6A", "Actin-related protein 10", "Actin-related protein 2", "Actin-related protein 2/3 complex subunit 1A", "Actin-related protein 2/3 complex subunit 1B", "Actin-related protein 2/3 complex subunit 3", "Actin-related protein 2/3 complex subunit 4", "Actin-related protein 2/3 complex subunit 5", "Actin-related protein 3", "Activating signal cointegrator 1", "Acyl-CoA dehydrogenase family member 11", "Acyl-CoA dehydrogenase family member 9, mitochondrial", "Acyl-CoA synthetase family member 3, mitochondrial", "Acyl-coenzyme A thioesterase 9, mitochondrial", "Acylamino-acid-releasing enzyme", "Acylpyruvase FAHD1, mitochondrial", "Acyltransferase", "Adenosine 3'-phospho 5'-phosphosulfate transporter 1", "Adenosine deaminase", "Adenosine kinase", "Adenosylhomocysteinase", "Adenylate kinase 2, mitochondrial", "Adenylate kinase 4, mitochondrial", "Adenylate kinase family", "Adenylate kinase isoenzyme 1", "Adenylosuccinate lyase", "Adenylosuccinate synthetase isozyme 2", "Adenylyl cyclase-associated protein 1", "Afadin", "Aflatoxin B1 aldehyde reductase member 2", "Alanine aminotransferase 2", "Alanine--tRNA ligase, cytoplasmic", "Alanine--tRNA ligase, mitochondrial", "Alanine/serine/cysteine transporter subfamily", "Alanyl-tRNA editing protein Aarsd1", "Alcohol dehydrogenase [NADP(+)]", "Alcohol dehydrogenase class-3", "Aldehyde dehydrogenase X, mitochondrial", "Aldehyde dehydrogenase, mitochondrial", "Aldose reductase", "Alpha-1,2-mannosyltransferase ALG9", "Alpha-adducin", "Alpha-aminoadipic semialdehyde dehydrogenase", "Alpha-centractin", "Alpha-enolase", "Alpha-globin transcription factor CP2", "Alpha-soluble NSF attachment protein", "Alpha-taxilin", "Amidophosphoribosyltransferase", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1", "Aminoacyl-tRNA synthetase", "Anaphase-promoting complex subunit 1", "Ancient ubiquitous protein 1", "Annexin", "Anoctamin-6", "Antibacterial response protein", "Apoptosis-inducing factor 1, mitochondrial", "Arfaptin-1", "Arginase-2, mitochondrial", "Asparagine synthetase [glutamine-hydrolyzing]", "Asparagine--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, mitochondrial", "Aspartic protease", "Ataxin-2", "Ataxin-2-like protein", "Atlastin-2", "Atp-dependent 6-phosphofructokinase, liver type", "Atypical group", "Aurora kinase a", "B-cell receptor-associated protein 31", "BTB/POZ domain-containing protein KCTD12", "BUB family", "BUB3-interacting and GLEBS motif-containing protein ZNF207", "Basic leucine zipper and W2 domain-containing protein 1", "Basic leucine zipper and W2 domain-containing protein 2", "Bcl-2-associated transcription factor 1", "Beta-centractin", "Beta-galactosidase", "Beta-hexosaminidase subunit alpha", "Beta-hexosaminidase subunit beta", "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1", "Bifunctional coenzyme A synthase", "Bifunctional glutamate/proline--tRNA ligase", "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial", "Bifunctional purine biosynthesis protein PURH", "Biliverdin reductase A", "Biogenesis of lysosome-related organelles complex 1 subunit 1", "Biotin--protein ligase", "Bleomycin hydrolase", "Brain-specific angiogenesis inhibitor 1-associated protein 2", "Breast cancer type 1 susceptibility protein", "Bromodomain", "Bromodomain-containing protein 2", "Bromodomain-containing protein 3", "Bromodomain-containing protein 4", "Bromodomain-containing protein 7", "C-1-tetrahydrofolate synthase, cytoplasmic", "C-Jun-amino-terminal kinase-interacting protein 4", "C-terminal-binding protein 1", "C-terminal-binding protein 2", "C2H2 zinc finger transcription factor", "CAAX prenyl protease 1 homolog", "CAD protein", "CAMK group", "CAMK2 family", "CAMKL family", "CASK family", "CCAAT/enhancer-binding protein zeta", "CCK4 family", "CCR4-NOT transcription complex subunit 1", "CCR4-NOT transcription complex subunit 3", "CCR4-NOT transcription complex subunit 7", "CD166 antigen", "CD2 antigen cytoplasmic tail-binding protein 2", "CD276 antigen", "CDK family", "CDK1 subfamily", "CDK4 subfamily", "CDK5 subfamily", "CDK7 subfamily", "CDK9 subfamily", "CDKN2A-interacting protein", "CK1 family", "CK1 group", "CK2 family", "CLIP-associating protein 2", "CMGC group", "COP9 signalosome complex subunit 3", "COP9 signalosome complex subunit 5", "COP9 signalosome complex subunit 6", "COP9 signalosome complex subunit 8", "CSK family", "CTP synthase 1", "CTP synthase 2", "Ca2+-ATPases", "Cadherin", "Calcium homeostasis endoplasmic reticulum protein", "Calcium uniporter protein, mitochondrial", "Calcium uptake protein 1, mitochondrial", "Calcium uptake protein 2, mitochondrial", "Calcium-binding mitochondrial carrier protein Aralar1", "Calcium-binding mitochondrial carrier protein Aralar2", "Calcium-binding mitochondrial carrier protein SCaMC-1", "Calcium-binding protein", "Calcium-binding protein 39", "Calcium-dependent chloride channel (ca-clc) family", "Calcium-regulated heat-stable protein 1", "Calcium-transporting ATPase type 2C member 1", "Calcium/calmodulin-dependent protein kinase type ii subunit delta", "Calcium/calmodulin-dependent protein kinase type ii subunit gamma", "Calcyclin-binding protein", "Calmegin", "Calmodulin", "Calnexin", "Calpain-1 catalytic subunit", "Calpain-2 catalytic subunit", "Calponin-2", "Calponin-3", "Calreticulin", "Calumenin", "Camp-dependent protein kinase catalytic subunit alpha", "Cancer-related nucleoside-triphosphatase", "Caprin-1", "Carbohydrate kinase", "Carbohydrate sulfotransferase 14", "Carnitine O-palmitoyltransferase 1, liver isoform", "Carnitine O-palmitoyltransferase 2, mitochondrial", "Cartilage-associated protein", "Casein kinase II subunit alpha'", "Casein kinase i isoform alpha", "Casein kinase i isoform epsilon", "Casein kinase ii subunit beta", "Catechol O-methyltransferase", "Catechol O-methyltransferase domain-containing protein 1", "Catenin alpha-1", "Catenin delta-1", "Cation-dependent mannose-6-phosphate receptor", "Cation-independent mannose-6-phosphate receptor", "Cell adhesion", "Cell cycle and apoptosis regulator protein 2", "Cell division control protein 42 homolog", "Cell division cycle and apoptosis regulator protein 1", "Cell-cell junction", "Cellular structure", "Cellular tumor antigen p53", "Centrin-2", "Centromere/kinetochore protein zw10 homolog", "Centrosomal protein of 170 kDa", "Chaperone", "Chaperonin", "Charged multivesicular body protein 3", "Charged multivesicular body protein 4b", "Charged multivesicular body protein 5", "Charged multivesicular body protein 7", "Chitobiosyldiphosphodolichol beta-mannosyltransferase", "Chloride channel family", "Chloride intracellular channel protein 1", "Chloride intracellular channel protein 4", "Choline kinase alpha", "Choline transporter-like protein 1", "Choline/ethanolamine kinase family", "Chromatin accessibility complex protein 1", "Chromatin assembly factor 1 subunit A", "Chromatin assembly factor 1 subunit B", "Chromatin/chromatin-binding protein", "Chromobox protein homolog 1", "Chromobox protein homolog 3", "Chromobox protein homolog 5", "Chromodomain", "Chromosome-associated kinesin KIF4A", "Cilia- and flagella-associated protein 20", "Citrate synthase, mitochondrial", "ClC-3/CLCN3 subfamily", "Class I transporters", "Class II transporters", "Clathrin heavy chain 1", "Clathrin light chain A", "Clathrin light chain B", "Cleavage and polyadenylation specificity factor subunit 1", "Cleavage and polyadenylation specificity factor subunit 3", "Cleavage and polyadenylation specificity factor subunit 5", "Cleavage and polyadenylation specificity factor subunit 6", "Cleavage and polyadenylation specificity factor subunit 7", "Cleavage stimulation factor subunit 2", "Cleavage stimulation factor subunit 3", "Cleft lip and palate transmembrane protein 1", "Cleft lip and palate transmembrane protein 1-like protein", "Clustered mitochondria protein homolog", "Coactosin-like protein", "Coatomer subunit alpha", "Coatomer subunit beta", "Coatomer subunit beta'", "Coatomer subunit delta", "Coatomer subunit epsilon", "Coatomer subunit gamma-1", "Coatomer subunit gamma-2", "Coatomer subunit zeta-1", "Cohesin subunit SA-1", "Cohesin subunit SA-2", "Coilin", "Cold-inducible RNA-binding protein", "Collectin-12", "Condensin complex subunit 1", "Copper-transporting ATPase 1", "Copper-transporting ATPase 2", "Core histone macro-H2A.1", "Core histone macro-H2A.2", "Coronin-1C", "Creatine kinase B-type", "Creatine kinase U-type, mitochondrial", "Crooked neck-like protein 1", "Cu+-ATPases", "Cullin-1", "Cullin-2", "Cullin-4B", "Cullin-5", "Cullin-associated NEDD8-dissociated protein 1", "Cyclase", "Cyclin-K", "Cyclin-dependent kinase 1", "Cyclin-dependent kinase 12", "Cyclin-dependent kinase 16", "Cyclin-dependent kinase 2", "Cyclin-dependent kinase 4", "Cyclin-dependent kinase 7", "Cyclin-dependent kinase 9", "Cyclin-dependent-like kinase 5", "Cyclin-g-associated kinase", "Cystatin-B", "Cysteine and histidine-rich domain-containing protein 1", "Cysteine desulfurase, mitochondrial", "Cysteine protease", "Cysteine protease ATG4B", "Cysteine protease inhibitor", "Cysteine--tRNA ligase, cytoplasmic", "Cytochrome b-c1 complex subunit 1, mitochondrial", "Cytochrome b-c1 complex subunit 2, mitochondrial", "Cytochrome b-c1 complex subunit 7", "Cytochrome b-c1 complex subunit 9", "Cytochrome b5 type B", "Cytochrome c oxidase subunit 2", "Cytochrome c oxidase subunit 5A, mitochondrial", "Cytochrome c oxidase subunit 5B, mitochondrial", "Cytochrome c oxidase subunit 7A-related protein, mitochondrial", "Cytochrome c oxidase subunit 7A2, mitochondrial", "Cytochrome c oxidase subunit 7C, mitochondrial", "Cytochrome c oxidase subunit NDUFA4", "Cytochrome c-type heme lyase", "Cytokine", "Cytoplasmic FMR1-interacting protein 1", "Cytoplasmic FMR1-interacting protein 2", "Cytoplasmic aconitate hydratase", "Cytoplasmic dynein 1 heavy chain 1", "Cytoplasmic dynein 1 light intermediate chain 1", "Cytoplasmic dynein 1 light intermediate chain 2", "Cytoplasmic dynein 2 heavy chain 1", "Cytoskeleton-associated protein 5", "Cytosol aminopeptidase", "Cytosolic 5'-nucleotidase 3A", "Cytosolic acyl coenzyme A thioester hydrolase", "Cytosolic non-specific dipeptidase", "Cytosolic purine 5'-nucleotidase", "D-3-phosphoglycerate dehydrogenase", "DDB1- and CUL4-associated factor 13", "DMPK family", "DNA (cytosine-5)-methyltransferase 1", "DNA binding protein", "DNA damage-binding protein 1", "DNA glycosylase", "DNA helicase", "DNA ligase", "DNA ligase 1", "DNA ligase 3", "DNA methyltransferase", "DNA mismatch repair protein Msh2", "DNA mismatch repair protein Msh3", "DNA mismatch repair protein Msh6", "DNA polymerase delta subunit 2", "DNA polymerase epsilon subunit 2", "DNA polymerase epsilon subunit 4", "DNA polymerase processivity factor", "DNA polymerase subunit gamma-1", "DNA primase small subunit", "DNA repair protein complementing XP-A cells", "DNA replication complex GINS protein PSF1", "DNA replication complex GINS protein PSF2", "DNA replication licensing factor MCM2", "DNA replication licensing factor MCM3", "DNA replication licensing factor MCM4", "DNA replication licensing factor MCM5", "DNA replication licensing factor MCM6", "DNA replication licensing factor MCM7", "DNA topoisomerase", "DNA topoisomerase 1", "DNA-3-methyladenine glycosylase", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "DNA-directed RNA polymerase I subunit RPA1", "DNA-directed RNA polymerase I subunit RPA2", "DNA-directed RNA polymerase II subunit RPB1", "DNA-directed RNA polymerase II subunit RPB2", "DNA-directed RNA polymerase II subunit RPB3", "DNA-directed RNA polymerase II subunit RPB4", "DNA-directed RNA polymerase II subunit RPB7", "DNA-directed RNA polymerase III subunit RPC1", "DNA-directed RNA polymerase III subunit RPC3", "DNA-directed RNA polymerase III subunit RPC5", "DNA-directed RNA polymerase, mitochondrial", "DNA-directed RNA polymerases I and III subunit RPAC1", "DNA-directed RNA polymerases I, II, and III subunit RPABC1", "DNA-directed RNA polymerases I, II, and III subunit RPABC3", "DNA-directed RNA polymerases I, II, and III subunit RPABC5", "DNAPK subfamily", "DYRK family", "Damaged DNA-binding protein", "Deacetylase", "Deaminase", "Death-inducer obliterator 1", "Decarboxylase", "Dedicator of cytokinesis protein 7", "Dehydratase", "Dehydrogenase", "Delta(24)-sterol reductase", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial", "Delta-1-pyrroline-5-carboxylate synthase", "Density-regulated protein", "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial", "Derlin-1", "Desmoglein-2", "Desmoplakin", "Digestive organ expansion factor homolog", "Dihydrofolate reductase", "Dihydrolipoyl dehydrogenase, mitochondrial", "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "Dihydroorotate dehydrogenase (quinone), mitochondrial", "Dihydropteridine reductase", "Dihydropyrimidinase-related protein 2", "Dipeptidyl peptidase 1", "Dipeptidyl peptidase 3", "Dipeptidyl peptidase 9", "Disks large homolog 1", "Disks large-associated protein 5", "Dna-dependent protein kinase catalytic subunit", "Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase", "Dolichol-phosphate mannosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B", "Dolichyldiphosphatase 1", "Double-stranded RNA-specific adenosine deaminase", "Drebrin", "Drebrin-like protein", "Dual specificity mitogen-activated protein kinase kinase 1", "Dual specificity mitogen-activated protein kinase kinase 2", "Dual specificity protein kinase ttk", "Dynactin subunit 1", "Dynactin subunit 2", "Dynamin-1-like protein", "Dynamin-2", "Dynamin-like 120 kDa protein, mitochondrial", "Dynein light chain 1, cytoplasmic", "Dynein light chain 2, cytoplasmic", "Dystonin", "Dystroglycan", "E3 SUMO-protein ligase RanBP2", "E3 ubiquitin-protein ligase ARIH1", "E3 ubiquitin-protein ligase ARIH2", "E3 ubiquitin-protein ligase HUWE1", "E3 ubiquitin-protein ligase MARCH5", "E3 ubiquitin-protein ligase NEDD4-like", "E3 ubiquitin-protein ligase RBBP6", "E3 ubiquitin-protein ligase ZNF598", "EF-hand domain-containing protein D2", "EH domain-containing protein 1", "EH domain-containing protein 4", "ELKS/Rab6-interacting/CAST family member 1", "ELMO domain-containing protein 2", "ER lumen protein-retaining receptor 1", "ER membrane protein complex subunit 2", "ERK subfamily", "ERO1-like protein alpha", "Early endosome antigen 1", "Electron transfer flavoprotein subunit alpha, mitochondrial", "Electron transfer flavoprotein subunit beta", "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial", "Elongation factor 1-alpha 2", "Elongation factor 1-beta", "Elongation factor 1-delta", "Elongation factor 2", "Elongation factor Ts, mitochondrial", "Elongation factor Tu, mitochondrial", "Elongation factor-like GTPase 1", "Elongator complex protein 1", "Elongator complex protein 3", "Elongin-B", "Elongin-C", "Endodeoxyribonuclease", "Endoplasmic reticulum aminopeptidase 1", "Endoplasmic reticulum metallopeptidase 1", "Endoplasmic reticulum protein SC65", "Endoplasmic reticulum resident protein 29", "Endoplasmin", "Endoribonuclease", "Endoribonuclease Dicer", "Endothelin-converting enzyme 1", "Engulfment and cell motility protein 2", "Enhancer of mRNA-decapping protein 4", "Enhancer of rudimentary homolog", "Enoyl-CoA delta isomerase 1, mitochondrial", "Enoyl-CoA delta isomerase 2, mitochondrial", "Enoyl-CoA hydratase, mitochondrial", "Enzyme", "Enzyme modulator", "Eph family", "Ephrin type-a receptor 7", "Epidermal growth factor receptor substrate 15", "Epidermal growth factor receptor substrate 15-like 1", "Epigenetic regulator", "Epimerase family protein SDR39U1", "Epimerase/racemase", "Epiplakin", "Equilibrative nucleoside transporter 1", "Eraser", "Esterase", "Ethylmalonyl-CoA decarboxylase", "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A", "Eukaryotic peptide chain release factor subunit 1", "Eukaryotic translation initiation factor 2 subunit 1", "Eukaryotic translation initiation factor 2 subunit 2", "Eukaryotic translation initiation factor 2A", "Eukaryotic translation initiation factor 2D", "Eukaryotic translation initiation factor 3 subunit A", "Eukaryotic translation initiation factor 3 subunit B", "Eukaryotic translation initiation factor 3 subunit D", "Eukaryotic translation initiation factor 3 subunit E", "Eukaryotic translation initiation factor 3 subunit F", "Eukaryotic translation initiation factor 3 subunit H", "Eukaryotic translation initiation factor 3 subunit I", "Eukaryotic translation initiation factor 3 subunit J", "Eukaryotic translation initiation factor 3 subunit L", "Eukaryotic translation initiation factor 4 gamma 1", "Eukaryotic translation initiation factor 4 gamma 2", "Eukaryotic translation initiation factor 4 gamma 3", "Eukaryotic translation initiation factor 4B", "Eukaryotic translation initiation factor 4E", "Eukaryotic translation initiation factor 4E type 2", "Eukaryotic translation initiation factor 4H", "Eukaryotic translation initiation factor 5", "Eukaryotic translation initiation factor 5A-1", "Eukaryotic translation initiation factor 5B", "Eukaryotic translation initiation factor 6", "Exocyst complex component 4", "Exocyst complex component 5", "Exocyst complex component 6", "Exocyst complex component 6B", "Exocyst complex component 7", "Exodeoxyribonuclease", "Exonuclease 1", "Exoribonuclease", "Exosome complex component CSL4", "Exosome complex component MTR3", "Exosome complex component RRP4", "Exosome complex component RRP40", "Exosome complex component RRP41", "Exosome complex component RRP42", "Exosome complex component RRP43", "Exosome complex component RRP45", "Exosome complex component RRP46", "Exosome complex exonuclease RRP44", "Exportin-1", "Exportin-2", "Exportin-4", "Exportin-5", "Exportin-7", "Exportin-T", "Extracellular matrix glycoprotein", "Extracellular matrix structural protein", "Extracellular structure", "Ezrin", "F-actin-capping protein subunit alpha-1", "F-actin-capping protein subunit alpha-2", "F-actin-capping protein subunit beta", "F-type ATPase", "F-type and V-type ATPases", "FACT complex subunit SPT16", "FAD-dependent oxidoreductase domain-containing protein 1", "FRAP subfamily", "FRAY subfamily", "Far upstream element-binding protein 1", "Far upstream element-binding protein 2", "Far upstream element-binding protein 3", "Farnesyl pyrophosphate synthase", "Fascin", "Fatty acid synthase", "Ferritin light chain", "Ferrochelatase, mitochondrial", "Flap endonuclease 1", "Flavin reductase (NADPH)", "Folate transporter 1", "Fragile X mental retardation syndrome-related protein 1", "Fragile X mental retardation syndrome-related protein 2", "Fumarate hydratase, mitochondrial", "G patch domain-containing protein 4", "G-patch domain and KOW motifs-containing protein", "G-protein", "G-protein coupled receptor", "G-protein modulator", "G-rich sequence factor 1", "G2/mitotic-specific cyclin-B1", "GC-rich sequence DNA-binding factor 2", "GMP synthase [glutamine-hydrolyzing]", "GPI-anchor transamidase", "GSK family", "GSK subfamily", "GTP-binding nuclear protein Ran", "GTP-binding protein 1", "GTPase Era, mitochondrial", "GTPase-activating protein and VPS9 domain-containing protein 1", "Galactokinase", "Galactosidase", "Galectin-3", "Gamma-adducin", "Gamma-aminobutyric acid receptor-associated protein-like 2", "Gamma-enolase", "Gamma-glutamyl hydrolase", "Gamma-taxilin", "Gamma-tubulin complex component 2", "Gamma-tubulin complex component 3", "Ganglioside GM2 activator", "General transcription factor 3C polypeptide 3", "General transcription factor 3C polypeptide 5", "General transcription factor IIF subunit 2", "General transcription factor IIH subunit 4", "General vesicular transport factor p115", "Geranylgeranyl transferase type-2 subunit alpha", "Glia maturation factor beta", "Glucosamine-6-phosphate isomerase 1", "Glucose-6-phosphate 1-dehydrogenase", "Glucose-6-phosphate isomerase", "Glucosidase", "Glucosidase 2 subunit beta", "Glutamate dehydrogenase 1, mitochondrial", "Glutamate--cysteine ligase catalytic subunit", "Glutaminase kidney isoform, mitochondrial", "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1", "Glutamine--tRNA ligase", "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial", "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial", "Glutaredoxin-3", "Glutaredoxin-related protein 5, mitochondrial", "Glutathione reductase, mitochondrial", "Glutathione synthetase", "Glyceraldehyde-3-phosphate dehydrogenase", "Glycerol-3-phosphate acyltransferase 4", "Glycerol-3-phosphate dehydrogenase 1-like protein", "Glycerol-3-phosphate dehydrogenase, mitochondrial", "Glycerol-3-phosphate phosphatase", "Glycine dehydrogenase (decarboxylating), mitochondrial", "Glycine--tRNA ligase", "Glycogen debranching enzyme", "Glycogen phosphorylase, brain form", "Glycogen phosphorylase, liver form", "Glycogen synthase kinase-3 alpha", "Glycogen synthase kinase-3 beta", "Glycogenin-1", "Glycolipid transfer protein", "Glycosidase", "Glycosylase", "Glycosyltransferase", "Glycylpeptide N-tetradecanoyltransferase 1", "Glyoxylate reductase/hydroxypyruvate reductase", "Golgi SNAP receptor complex member 1", "Golgi SNAP receptor complex member 2", "Golgi pH regulator family", "Golgi ph regulator b", "Golgin subfamily A member 2", "Group XV phospholipase A2", "Growth factor", "GrpE protein homolog 1, mitochondrial", "Guanine nucleotide-binding protein G(i) subunit alpha-1", "Guanine nucleotide-binding protein G(i) subunit alpha-2", "Guanine nucleotide-binding protein G(k) subunit alpha", "Guanine nucleotide-binding protein G(o) subunit alpha", "Guanine nucleotide-binding protein subunit alpha-13", "Guanyl-nucleotide exchange factor", "H(+)/Cl(-) exchange transporter 3", "H/ACA ribonucleoprotein complex subunit 1", "H/ACA ribonucleoprotein complex subunit 2", "H/ACA ribonucleoprotein complex subunit 3", "HBS1-like protein", "HDAC class I", "HDAC class III", "HEAT repeat-containing protein 1", "HIV Tat-specific factor 1", "Haloacid dehalogenase-like hydrolase domain-containing 5", "Haloacid dehalogenase-like hydrolase domain-containing protein 2", "Heat shock protein 75 kDa, mitochondrial", "Heat shock protein HSP 90-alpha", "Heat shock protein HSP 90-beta", "Helicase", "Hepatoma-derived growth factor", "Hepatoma-derived growth factor-related protein 2", "Heterogeneous nuclear ribonucleoprotein F", "Heterogeneous nuclear ribonucleoprotein H", "Heterogeneous nuclear ribonucleoprotein H2", "Heterogeneous nuclear ribonucleoprotein H3", "Heterogeneous nuclear ribonucleoprotein K", "Heterogeneous nuclear ribonucleoprotein M", "Heterogeneous nuclear ribonucleoprotein Q", "Heterogeneous nuclear ribonucleoprotein R", "Heterotrimeric G-protein", "Hexokinase family", "Hexokinase-1", "Hexokinase-2", "High affinity cationic amino acid transporter 1", "High mobility group protein B1", "High mobility group protein B2", "High mobility group protein B3", "High mobility group protein HMG-I/HMG-Y", "Histidine triad nucleotide-binding protein 2, mitochondrial", "Histone", "Histone H1.0", "Histone H1.2", "Histone H1.3", "Histone H1.4", "Histone H1x", "Histone H2AX", "Histone H4", "Histone acetyltransferase KAT7", "Histone acetyltransferase type B catalytic subunit", "Histone chaperone ASF1A", "Histone deacetylase", "Histone deacetylase 1", "Histone deacetylase 2", "Histone deacetylase complex subunit SAP18", "Histone-arginine methyltransferase CARM1", "Histone-lysine N-methyltransferase EHMT1", "Histone-lysine N-methyltransferase EHMT2", "Histone-lysine N-methyltransferase NSD2", "Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific", "Hormone", "Hsp90 co-chaperone Cdc37", "Hsp90 family chaperone", "Hydrolase", "Hydroxylase", "Hydroxymethylglutaryl-CoA lyase, mitochondrial", "Hypoxanthine-guanine phosphoribosyltransferase", "Immune response", "Immunoglobulin fold transcription factor", "Immunoglobulin superfamily cell adhesion molecule", "Importin subunit alpha-1", "Importin subunit alpha-3", "Importin subunit alpha-4", "Importin subunit alpha-5", "Importin subunit beta-1", "Importin-11", "Importin-4", "Importin-5", "Importin-7", "Importin-8", "Importin-9", "Inactive serine/threonine-protein kinase vrk3", "Inactive tyrosine-protein kinase 7", "Induced myeloid leukemia cell differentiation protein Mcl-1", "Inorganic pyrophosphatase", "Inorganic pyrophosphatase 2, mitochondrial", "Inosine triphosphate pyrophosphatase", "Inosine-5'-monophosphate dehydrogenase 1", "Inosine-5'-monophosphate dehydrogenase 2", "Inositol monophosphatase 3", "Inositol polyphosphate 5-phosphatase OCRL-1", "Insulin-degrading enzyme", "Insulin-like growth factor 2 mRNA-binding protein 1", "Insulin-like growth factor 2 mRNA-binding protein 2", "Insulin-like growth factor 2 mRNA-binding protein 3", "Integrator complex subunit 11", "Integrin beta-1", "Integrin-linked kinase-associated serine/threonine phosphatase 2C", "Interferon-induced, double-stranded rna-activated protein kinase", "Interferon-inducible double-stranded rna-dependent protein kinase activator a", "Interleukin enhancer-binding factor 3", "Intermediate filament", "Intermediate filament binding protein", "Intracellular calcium-sensing protein", "Intracellular chloride channel (clic) family", "Ion channel", "Isoaspartyl peptidase/L-asparaginase", "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial", "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial", "Isoleucine--tRNA ligase, cytoplasmic", "Isoleucine--tRNA ligase, mitochondrial", "Isomerase", "Isopentenyl-diphosphate Delta-isomerase 1", "Isovaleryl-CoA dehydrogenase, mitochondrial", "Jumonji domain-containing", "KH domain-containing, RNA-binding, signal transduction-associated protein 1", "KRAB box transcription factor", "KRR1 small subunit processome component homolog", "Kinase", "Kinase activator", "Kinase inhibitor", "Kinase modulator", "Kinesin-1 heavy chain", "Kinesin-like protein KIF11", "Kinesin-like protein KIF14", "Kinesin-like protein KIF1A", "Kinesin-like protein KIF20A", "Kinesin-like protein KIF22", "Kinesin-like protein KIF23", "Kinesin-like protein KIF2A", "Kinesin-like protein KIF2C", "Kinesin-like protein KIF3A", "Kynurenine--oxoglutarate transaminase 3", "L-2-hydroxyglutarate dehydrogenase, mitochondrial", "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase", "L-lactate dehydrogenase A chain", "L-lactate dehydrogenase B chain", "LIM domain and actin-binding protein 1", "LIM domain-binding protein 1", "LU7TM family", "La-related protein 1", "La-related protein 4", "La-related protein 4B", "La-related protein 7", "Lamin-B receptor", "Lamina-associated polypeptide 2, isoform alpha", "Laminin subunit beta-1", "Lanosterol 14-alpha demethylase", "Large proline-rich protein BAG6", "Lathosterol oxidase", "Lethal(2) giant larvae protein homolog 1", "Leucine-rich repeat and WD repeat-containing protein 1", "Leucine-rich repeat-containing protein 47", "Leucyl-cystinyl aminopeptidase", "Leukocyte elastase inhibitor", "Ligase", "Lipase", "Lipid kinase", "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial", "Lon protease homolog, mitochondrial", "Long-chain fatty acid transport protein 4", "Long-chain-fatty-acid--CoA ligase 1", "Long-chain-fatty-acid--CoA ligase 3", "Long-chain-fatty-acid--CoA ligase 4", "Lupus La protein", "Lyase", "Lymphokine-activated killer t-cell-originated protein kinase", "Lysine demethylase", "Lysine--tRNA ligase", "Lysine-specific demethylase", "Lysine-specific demethylase 3B", "Lysine-specific histone demethylase 1A", "Lysine-specific histone demethylase 1B", "Lysophosphatidic acid phosphatase type 6", "Lysophosphatidylcholine acyltransferase 1", "Lysophospholipid acyltransferase 7", "Lysosomal Pro-X carboxypeptidase", "Lysosomal acid lipase/cholesteryl ester hydrolase", "Lysosomal acid phosphatase", "Lysosomal alpha-glucosidase", "Lysosomal protective protein", "Lysosomal thioesterase PPT2", "Lysosome membrane protein 2", "Lysosome-associated membrane glycoprotein 1", "Lysosome-associated membrane glycoprotein 2", "MAGUK p55 subfamily member 2", "MAGUK p55 subfamily member 6", "MAP7 domain-containing protein 1", "MAPK family", "MARK subfamily", "MCU family", "MLK family", "MMS19 nucleotide excision repair protein homolog", "MST subfamily", "Magnesium transporter protein 1", "Major histocompatibility complex antigen", "Malate dehydrogenase, cytoplasmic", "Malate dehydrogenase, mitochondrial", "Malignant T-cell-amplified sequence 1", "Mannose-6-phosphate isomerase", "Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA", "Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB", "Mediator of RNA polymerase II transcription subunit 14", "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "Melanoma inhibitory activity protein 2", "Melanoma-associated antigen D2", "Membrane trafficking regulatory protein", "Membrane-associated progesterone receptor component 1", "Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase", "Metalloendopeptidase OMA1, mitochondrial", "Metalloprotease", "Metastasis-associated protein MTA1", "Metastasis-associated protein MTA2", "Methyl-CpG-binding domain", "Methyl-CpG-binding protein 2", "Methyl-lysine/arginine binding protein", "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial", "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial", "Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial", "Methylmalonyl-CoA mutase, mitochondrial", "Methylosome subunit pICln", "Methylsterol monooxygenase 1", "Methyltransferase", "Microfibrillar-associated protein 1", "Microsomal glutathione S-transferase 2", "Microsomal glutathione S-transferase 3", "Microtubule binding motor protein", "Microtubule family cytoskeletal protein", "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5", "Microtubule-associated protein 1B", "Microtubule-associated protein 1S", "Microtubule-associated protein RP/EB family member 1", "Microtubule-associated protein RP/EB family member 2", "Minor histocompatibility antigen H13", "Miscellaneous SLC25 mitochondrial transporters", "Mitochondrial 2-oxodicarboxylate carrier", "Mitochondrial 2-oxoglutarate/malate carrier protein", "Mitochondrial Rho GTPase 2", "Mitochondrial amino acid transporter subfamily", "Mitochondrial cardiolipin hydrolase", "Mitochondrial carnitine/acylcarnitine carrier protein", "Mitochondrial carrier homolog 1", "Mitochondrial carrier homolog 2", "Mitochondrial di- and tri-carboxylic acid transporter subfamily", "Mitochondrial dicarboxylate carrier", "Mitochondrial folate transporter/carrier", "Mitochondrial glutamate carrier 1", "Mitochondrial import receptor subunit TOM20 homolog", "Mitochondrial import receptor subunit TOM40 homolog", "Mitochondrial inner membrane protein OXA1L", "Mitochondrial intermediate peptidase", "Mitochondrial nucleotide transporter subfamily", "Mitochondrial phosphate transporters", "Mitochondrial proton/calcium exchanger protein", "Mitochondrial pyruvate carrier 2", "Mitochondrial thiamine pyrophosphate carrier", "Mitochondrial-processing peptidase subunit alpha", "Mitochondrial-processing peptidase subunit beta", "Mitofusin-2", "Mitogen-activated protein kinase 1", "Mitogen-activated protein kinase 14", "Mitogen-activated protein kinase 3", "Mitogen-activated protein kinase kinase kinase 7", "Mitotic checkpoint protein BUB3", "Mitotic checkpoint serine/threonine-protein kinase bub1 beta", "Moesin", "Molybdate-anion transporter", "Monoacylglycerol lipase ABHD12", "Monocarboxylate transporter 1", "Monofunctional C1-tetrahydrofolate synthase, mitochondrial", "Mortality factor 4-like protein 1", "Mpv17-like protein 2", "Multidrug resistance protein 1", "Multifunctional protein ADE2", "Mutase", "Myb-binding protein 1A", "Myelin expression factor 2", "Myosin light polypeptide 6", "Myosin phosphatase Rho-interacting protein", "N(G),N(G)-dimethylarginine dimethylaminohydrolase 2", "N-acetylglucosamine-6-sulfatase", "N-acylneuraminate cytidylyltransferase", "N-alpha-acetyltransferase 10", "N-alpha-acetyltransferase 15, NatA auxiliary subunit", "N-alpha-acetyltransferase 25, NatB auxiliary subunit", "N-alpha-acetyltransferase 50", "NAD kinase 2, mitochondrial", "NAD(P) transhydrogenase, mitochondrial", "NAD-dependent malic enzyme, mitochondrial", "NAD-dependent protein deacetylase sirtuin-1", "NAD-dependent protein deacetylase sirtuin-2", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial", "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial", "NADH-ubiquinone oxidoreductase chain 5", "NADP-dependent malic enzyme", "NADPH:adrenodoxin oxidoreductase, mitochondrial", "NAK family", "NDR family", "NEDD8-activating enzyme E1 catalytic subunit", "NEDD8-activating enzyme E1 regulatory subunit", "NEK family", "NF-X1-type zinc finger protein NFXL1", "NF-kappa-B-repressing factor", "NHP2-like protein 1", "NRBP family", "NSFL1 cofactor p47", "Na+/K+-ATPases", "Nardilysin", "Neurofibromin", "Neurolysin, mitochondrial", "Neuropathy target esterase", "Neutral alpha-glucosidase AB", "Neutral amino acid transporter B(0)", "Nf-kappa-b essential modulator", "Nibrin", "Nicotinamide phosphoribosyltransferase", "Nipped-B-like protein", "Nischarin", "Non-POU domain-containing octamer-binding protein", "Non-histone chromosomal protein HMG-14", "Non-motor actin binding protein", "Non-motor microtubule binding protein", "Non-protein kinase", "Non-structural maintenance of chromosomes element 3 homolog", "Nuclear RNA export factor 1", "Nuclear cap-binding protein subunit 1", "Nuclear factor related to kappa-B-binding protein", "Nuclear migration protein nudC", "Nuclear pore complex protein Nup107", "Nuclear pore complex protein Nup153", "Nuclear pore complex protein Nup160", "Nuclear pore complex protein Nup214", "Nuclear pore complex protein Nup85", "Nuclear pore complex protein Nup88", "Nuclear pore complex protein Nup93", "Nuclear pore complex protein Nup98-Nup96", "Nuclear pore glycoprotein p62", "Nuclear pore membrane glycoprotein 210", "Nuclear receptor coactivator 5", "Nuclear receptor corepressor 1", "Nuclear receptor-binding protein", "Nuclease", "Nucleic acid binding", "Nucleobindin-1", "Nucleobindin-2", "Nucleolar MIF4G domain-containing protein 1", "Nucleolar complex protein 4 homolog", "Nucleolar protein 14", "Nucleolar protein 56", "Nucleolar protein 58", "Nucleolar protein 6", "Nucleolar protein 9", "Nucleolin", "Nucleophosmin", "Nucleoporin Nup37", "Nucleoporin SEH1", "Nucleoporin p54", "Nucleoside diphosphate kinase A", "Nucleoside diphosphate kinase B", "Nucleoside kinase", "Nucleosome assembly protein 1-like 1", "Nucleosome assembly protein 1-like 4", "Nucleotide kinase", "Nucleotide phosphatase", "Nucleotidyltransferase", "NudC domain-containing protein 2", "NudC domain-containing protein 3", "OCIA domain-containing protein 1", "Obg-like ATPase 1", "Occludin", "Origin recognition complex subunit 2", "Origin recognition complex subunit 3", "Origin recognition complex subunit 5", "Ornithine aminotransferase, mitochondrial", "Other 7TM proteins", "Other group", "Other small molecule kinase", "Oxidase", "Oxidoreductase", "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial", "Oxygenase", "P-type ATPases", "P38 subfamily", "P53-like transcription factor", "PAKA subfamily", "PAKB subfamily", "PC4 and SFRS1-interacting protein", "PDHK family", "PDZ and LIM domain protein 1", "PDZ and LIM domain protein 5", "PDZ domain-containing protein GIPC1", "PEK family", "PH-interacting protein", "PHD finger protein 10", "PHD finger protein 3", "PHD finger protein 6", "PI3/PI4 kinase family", "PIKK family", "PIN2/TERF1-interacting telomerase inhibitor 1", "PKA family", "PKC delta subfamily", "PKC family", "PKN family", "PLK family", "Paired amphipathic helix protein Sin3a", "Paired amphipathic helix protein Sin3b", "Palmitoyl-protein thioesterase 1", "Pantothenate kinase 4", "Paraspeckle component 1", "Pentatricopeptide repeat-containing protein 1, mitochondrial", "Peptidase M20 domain-containing protein 2", "Peptidyl-prolyl cis-trans isomerase FKBP4", "Peptidyl-prolyl cis-trans isomerase FKBP5", "Peptidyl-prolyl cis-trans isomerase-like 1", "Perilipin-3", "Periodic tryptophan protein 1 homolog", "Peripheral plasma membrane protein cask", "Peroxidase", "Peroxiredoxin-2", "Peroxiredoxin-4", "Peroxiredoxin-6", "Peroxisomal acyl-coenzyme A oxidase 1", "Peroxisomal acyl-coenzyme A oxidase 3", "Peroxisomal bifunctional enzyme", "Peroxisomal biogenesis factor 19", "Peroxisomal membrane protein 2", "Peroxisomal membrane protein PEX14", "Peroxisomal membrane protein PMP34", "Peroxisomal trans-2-enoyl-CoA reductase", "Pescadillo homolog", "Phenylalanine--tRNA ligase beta subunit", "Phosphatase", "Phosphatase activator", "Phosphatase inhibitor", "Phosphatase modulator", "Phosphate carrier protein, mitochondrial", "Phosphatidylethanolamine-binding protein 1", "Phosphatidylinositol 3-kinase regulatory subunit beta", "Phosphatidylinositol 4-kinase alpha", "Phosphatidylinositol 4-kinase type 2-alpha", "Phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit alpha", "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma", "Phosphatidylinositol transfer protein beta isoform", "Phosphatidylinositol-binding clathrin assembly protein", "Phosphatidylserine synthase 1", "Phosphatidylserine synthase 2", "Phosphodiesterase", "Phosphoenolpyruvate carboxykinase [GTP] family", "Phosphoenolpyruvate carboxykinase [gtp], mitochondrial", "Phosphofructokinase type A (PFKA) family", "Phosphoglycerate kinase 1", "Phosphoglycerate kinase family", "Phosphoinositide 3-kinase (PI3K) family", "Phospholipase", "Phospholipase A-2-activating protein", "Phosphoribosyl pyrophosphate synthase-associated protein 1", "Phosphoribosyl pyrophosphate synthase-associated protein 2", "Phosphorylase", "Phosphorylated adapter RNA export protein", "Phosphoserine phosphatase", "Pirin", "Plasma membrane calcium-transporting ATPase 1", "Plasma membrane calcium-transporting ATPase 4", "Plasminogen activator inhibitor 1 RNA-binding protein", "Plastin-1", "Plastin-3", "Plectin", "Pogo transposable element with ZNF domain", "Poly(A) RNA polymerase, mitochondrial", "Poly(A) polymerase alpha", "Poly(A)-specific ribonuclease PARN", "Poly(rC)-binding protein 1", "Poly(rC)-binding protein 2", "Polycomb protein SUZ12", "Polyglutamine-binding protein 1", "Polyhomeotic-like protein 2", "Polymerase", "Polymerase delta-interacting protein 3", "Polypeptide N-acetylgalactosaminyltransferase 1", "Polypeptide N-acetylgalactosaminyltransferase 2", "Polyribonucleotide nucleotidyltransferase 1, mitochondrial", "Porphobilinogen deaminase", "Pre-mRNA-processing factor 6", "Pre-mRNA-processing-splicing factor 8", "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15", "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16", "Pre-mRNA-splicing factor RBM22", "Pre-mRNA-splicing factor SPF27", "Pre-mRNA-splicing factor SYF1", "Prefoldin subunit 2", "Prefoldin subunit 3", "Prefoldin subunit 5", "Prenylated Rab acceptor protein 1", "Presenilins-associated rhomboid-like protein, mitochondrial", "Presequence protease, mitochondrial", "Primase", "Probable 18S rRNA (guanine-N(7))-methyltransferase", "Probable ATP-dependent RNA helicase DHX37", "Probable ATP-dependent RNA helicase DHX40", "Probable RNA-binding protein 19", "Probable U3 small nucleolar RNA-associated protein 11", "Probable cysteine--tRNA ligase, mitochondrial", "Probable global transcription activator SNF2L1", "Probable glutamate--tRNA ligase, mitochondrial", "Probable glutathione peroxidase 8", "Probable helicase with zinc finger domain", "Probable histidine--tRNA ligase, mitochondrial", "Probable leucine--tRNA ligase, mitochondrial", "Probable serine carboxypeptidase CPVL", "Probable tRNA N6-adenosine threonylcarbamoyltransferase", "Probable tRNA pseudouridine synthase 1", "Procollagen galactosyltransferase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2", "Programmed cell death 6-interacting protein", "Programmed cell death protein 5", "Prolactin regulatory element-binding protein", "Proliferating cell nuclear antigen", "Prolyl 3-hydroxylase 1", "Prolyl endopeptidase", "Propionyl-CoA carboxylase alpha chain, mitochondrial", "Propionyl-CoA carboxylase beta chain, mitochondrial", "Prostaglandin E synthase 2", "Prostaglandin E synthase 3", "Prostaglandin reductase 1", "Prostaglandin reductase 2", "Prostaglandin reductase 3", "Protease", "Protease inhibitor", "Protein AATF", "Protein BUD31 homolog", "Protein CMSS1", "Protein DDI1 homolog 2", "Protein ERGIC-53", "Protein FAM177A1", "Protein FRG1", "Protein LSM14 homolog B", "Protein NDRG3", "Protein PRRC2A", "Protein PRRC2B", "Protein PRRC2C", "Protein RRP5 homolog", "Protein Red", "Protein S100-A10", "Protein S100-A11", "Protein S100-A13", "Protein SCO1 homolog, mitochondrial", "Protein SCO2 homolog, mitochondrial", "Protein SEC13 homolog", "Protein SET", "Protein Wiz", "Protein arginine N-methyltransferase 1", "Protein arginine N-methyltransferase 3", "Protein arginine N-methyltransferase 5", "Protein arginine methyltransferase", "Protein farnesyltransferase subunit beta", "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "Protein gpr107", "Protein kinase", "Protein kinase C and casein kinase substrate in neurons protein 2", "Protein kinase C and casein kinase substrate in neurons protein 3", "Protein kinase c delta type", "Protein methyltransferase", "Protein phosphatase", "Protein phosphatase 1F", "Protein phosphatase 1G", "Protein phosphatase methylesterase 1", "Protein polybromo-1", "Protein quaking", "Protein regulator of cytokinesis 1", "Protein strawberry notch homolog 1", "Protein transport protein Sec23A", "Protein transport protein Sec23B", "Protein transport protein Sec24A", "Protein transport protein Sec24C", "Protein transport protein Sec24D", "Protein transport protein Sec31A", "Protein transport protein Sec61 subunit alpha isoform 1", "Protein unc-119 homolog B", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase", "Protein/nucleic acid deglycase DJ-1", "Pterin-4-alpha-carbinolamine dehydratase", "Pumilio homolog 1", "Purine nucleoside phosphorylase", "Puromycin-sensitive aminopeptidase", "Putative oxidoreductase GLYR1", "Putative phospholipase B-like 2", "Pyridoxal kinase", "Pyridoxine kinase family", "Pyrophosphatase", "Pyruvate carboxylase, mitochondrial", "Pyruvate dehydrogenase protein X component, mitochondrial", "Pyruvate kinase pkm", "RAD53 family", "RIO family", "RIO2 subfamily", "RIPK family", "RNA 3'-terminal phosphate cyclase", "RNA 3'-terminal phosphate cyclase-like protein", "RNA binding protein", "RNA helicase", "RNA-binding motif protein, X chromosome", "RNA-binding protein 12", "RNA-binding protein 12B", "RNA-binding protein 14", "RNA-binding protein 26", "RNA-binding protein 27", "RNA-binding protein 3", "RNA-binding protein 4", "RNA-binding protein 7", "RNA-binding protein EWS", "RNA-binding protein FUS", "RNA-binding protein with serine-rich domain 1", "ROCK subfamily", "RSK family", "RSK subfamily", "Rab GDP dissociation inhibitor alpha", "Rab GDP dissociation inhibitor beta", "Rab GTPase-activating protein 1", "Rab3 GTPase-activating protein non-catalytic subunit", "Rab5 GDP/GTP exchange factor", "Rac GTPase-activating protein 1", "Rac-beta serine/threonine-protein kinase", "Radixin", "RalBP1-associated Eps domain-containing protein 1", "Ran GTPase-activating protein 1", "Ran-binding protein 3", "Ran-specific GTPase-activating protein", "Rap guanine nucleotide exchange factor 2", "Ras GTPase-activating protein 1", "Ras GTPase-activating protein-binding protein 1", "Ras GTPase-activating protein-binding protein 2", "Ras GTPase-activating-like protein IQGAP1", "Ras GTPase-activating-like protein IQGAP2", "Ras GTPase-activating-like protein IQGAP3", "Ras-related C3 botulinum toxin substrate 1", "Ras-related protein R-Ras2", "Ras-related protein Ral-A", "Ras-related protein Rap-2b", "Reader", "Receptor", "Receptor expression-enhancing protein 4", "Receptor expression-enhancing protein 5", "Receptor-interacting serine/threonine-protein kinase 1", "Receptor-type tyrosine-protein phosphatase F", "Recombining binding protein suppressor of hairless", "Reductase", "Regulation of nuclear pre-mRNA domain-containing protein 1A", "Regulation of nuclear pre-mRNA domain-containing protein 1B", "Regulation of nuclear pre-mRNA domain-containing protein 2", "Regulator of nonsense transcripts 1", "Remodeling and spacing factor 1", "Renin receptor", "Replication factor C subunit 2", "Replication factor C subunit 3", "Replication factor C subunit 4", "Replication factor C subunit 5", "Replication origin binding protein", "Replication protein A 70 kDa DNA-binding subunit", "Reticulocalbin-1", "Reticulocalbin-2", "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "Retinoid-inducible serine carboxypeptidase", "Retinol dehydrogenase 11", "Retinol dehydrogenase 14", "Rho GDP-dissociation inhibitor 1", "Rho-associated protein kinase 1", "Rho-associated protein kinase 2", "Ribonuclease H2 subunit A", "Ribonuclease P protein subunit p30", "Ribonuclease inhibitor", "Ribonucleoprotein", "Ribonucleoprotein PTB-binding 1", "Ribonucleoside-diphosphate reductase large subunit", "Ribonucleoside-diphosphate reductase subunit M2", "Ribose-phosphate pyrophosphokinase 1", "Ribosomal L1 domain-containing protein 1", "Ribosomal RNA small subunit methyltransferase NEP1", "Ribosomal RNA-processing protein 7 homolog A", "Ribosomal protein", "Ribosomal protein s6 kinase alpha-1", "Ribosomal protein s6 kinase alpha-3", "Ribosome biogenesis protein BOP1", "Ribosome biogenesis protein BRX1 homolog", "Ribosome biogenesis regulatory protein homolog", "Ribosome maturation protein SBDS", "Ribosome production factor 1", "Ribosome production factor 2 homolog", "S-adenosylhomocysteine hydrolase-like protein 1", "S-adenosylmethionine mitochondrial carrier protein", "S-adenosylmethionine synthase isoform type-2", "S-formylglutathione hydrolase", "S-methyl-5'-thioadenosine phosphorylase", "S-phase kinase-associated protein 1", "SAP30-binding protein", "SCY1 family", "SEC23-interacting protein", "SET domain", "SLC superfamily of solute carriers", "SLC1 family of amino acid transporters", "SLC12 family of cation-coupled chloride transporters", "SLC16 family of monocarboxylate transporters", "SLC19 family of vitamin transporters", "SLC2 family of hexose and sugar alcohol transporters", "SLC25 family of mitochondrial transporters", "SLC27 family of fatty acid transporters", "SLC28 and SLC29 families of nucleoside transporters", "SLC29 family", "SLC3 and SLC7 families of heteromeric amino acid transporters (HATs)", "SLC3 family", "SLC30 zinc transporter family", "SLC35 family of nucleotide sugar transporters", "SLC38 family of sodium-dependent neutral amino acid transporters", "SLC39 family of metal ion transporters", "SLC4 family of bicarbonate transporters", "SLC44 choline transporter-like family", "SLC54 Mitochondrial pyruvate carriers", "SLC55 Mitochondrial cation/proton exchangers", "SLC56 Sideroflexins", "SLC58 MagT-like magnesium transporter family", "SLC61 Molybdate transporter family", "SLC7 family", "SLK subfamily", "SNARE protein", "SNW domain-containing protein 1", "SRPK family", "STAM-binding protein", "STE group", "STE20 family", "STE7 family", "SUMO-activating enzyme subunit 1", "SUMO-activating enzyme subunit 2", "SUN domain-containing protein 1", "SUN domain-containing protein 2", "SURP and G-patch domain-containing protein 1", "SURP and G-patch domain-containing protein 2", "SWI/SNF complex subunit SMARCC1", "SWI/SNF complex subunit SMARCC2", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1", "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "Scavenger receptor class B member 1", "Scy1-like protein 2", "Sec1 family domain-containing protein 1", "Secretory carrier-associated membrane protein 1", "Secretory carrier-associated membrane protein 2", "Secretory carrier-associated membrane protein 3", "Secretory carrier-associated membrane protein 4", "Selenide, water dikinase 1", "Selenocysteine-specific elongation factor", "Sentrin-specific protease 3", "Septin-11", "Septin-2", "Septin-7", "Septin-9", "Serine hydroxymethyltransferase, cytosolic", "Serine hydroxymethyltransferase, mitochondrial", "Serine palmitoyltransferase 1", "Serine palmitoyltransferase 2", "Serine protease", "Serine protease inhibitor", "Serine--tRNA ligase, cytoplasmic", "Serine--tRNA ligase, mitochondrial", "Serine/arginine repetitive matrix protein 1", "Serine/arginine-rich splicing factor 1", "Serine/arginine-rich splicing factor 10", "Serine/arginine-rich splicing factor 11", "Serine/arginine-rich splicing factor 3", "Serine/arginine-rich splicing factor 4", "Serine/arginine-rich splicing factor 5", "Serine/arginine-rich splicing factor 6", "Serine/arginine-rich splicing factor 7", "Serine/arginine-rich splicing factor 9", "Serine/threonine-protein kinase 26", "Serine/threonine-protein kinase 38", "Serine/threonine-protein kinase 4", "Serine/threonine-protein kinase chk2", "Serine/threonine-protein kinase mark2", "Serine/threonine-protein kinase mtor", "Serine/threonine-protein kinase n2", "Serine/threonine-protein kinase nek9", "Serine/threonine-protein kinase osr1", "Serine/threonine-protein kinase pak 2", "Serine/threonine-protein kinase pak 4", "Serine/threonine-protein kinase plk1", "Serine/threonine-protein kinase prp4 homolog", "Serine/threonine-protein kinase rio2", "Serine/threonine-protein kinase vrk1", "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform", "Serine/threonine-protein phosphatase 2A activator", "Serine/threonine-protein phosphatase 4 regulatory subunit 1", "Serine/threonine-protein phosphatase 6 regulatory subunit 3", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit", "Serine/threonine-protein phosphatase PP1-beta catalytic subunit", "Serpin B6", "Serpin H1", "Set1/Ash2 histone methyltransferase complex subunit ASH2", "Sex comb on midleg-like protein 2", "Sialic acid synthase", "Sideroflexin-1", "Sideroflexin-2", "Sigma intracellular receptor 2", "Signal peptidase complex subunit 2", "Signal peptidase complex subunit 3", "Signal recognition particle 14 kDa protein", "Signal recognition particle 54 kDa protein", "Signal recognition particle 9 kDa protein", "Signal recognition particle receptor subunit alpha", "Signal recognition particle subunit SRP68", "Signal transducer and activator of transcription 1-alpha/beta", "Signal transducer and activator of transcription 3", "Signaling", "Single-stranded DNA-binding protein, mitochondrial", "Sister chromatid cohesion protein PDS5 homolog A", "Sister chromatid cohesion protein PDS5 homolog B", "Small GTPase", "Small nuclear ribonucleoprotein E", "Small nuclear ribonucleoprotein Sm D1", "Small nuclear ribonucleoprotein Sm D2", "Small nuclear ribonucleoprotein Sm D3", "Sodium bicarbonate cotransporter 3", "Sodium-coupled neutral amino acid transporter 1", "Sodium-dependent HCO3- transporters", "Sodium/potassium-transporting ATPase subunit alpha-1", "Sodium/potassium-transporting ATPase subunit beta-1", "Sodium/potassium-transporting ATPase subunit beta-3", "Solute carrier family 12 member 2", "Solute carrier family 12 member 9", "Solute carrier family 2, facilitated glucose transporter member 1", "Solute carrier family 2, facilitated glucose transporter member 8", "Solute carrier family 35 member F2", "Something about silencing protein 10", "Sorbitol dehydrogenase", "Sorting nexin-1", "Sorting nexin-2", "Spermatid perinuclear RNA-binding protein", "Spermidine synthase", "Splicing factor 1", "Splicing factor 3A subunit 1", "Splicing factor 3A subunit 2", "Splicing factor 3A subunit 3", "Splicing factor 3B subunit 1", "Splicing factor 3B subunit 3", "Splicing factor 45", "Splicing factor U2AF 35 kDa subunit", "Splicing factor, arginine/serine-rich 15", "Splicing factor, proline- and glutamine-rich", "Splicing factor, suppressor of white-apricot homolog", "Splicing regulatory glutamine/lysine-rich protein 1", "Squalene monooxygenase", "Squamous cell carcinoma antigen recognized by T-cells 3", "Src substrate cortactin", "Srsf protein kinase 1", "Staphylococcal nuclease domain-containing protein 1", "Ste20-like serine/threonine-protein kinase", "Sterol O-acyltransferase 1", "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating", "Stomatin-like protein 2, mitochondrial", "Storage", "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial", "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial", "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial", "Succinate-semialdehyde dehydrogenase, mitochondrial", "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial", "Sulfhydryl oxidase 2", "Superoxide dismutase [Mn], mitochondrial", "Surfeit locus protein 4", "Surfeit locus protein 6", "Survival motor neuron protein", "Synaptogyrin-2", "Synaptojanin-2-binding protein", "Synaptosomal-associated protein 23", "Synaptosomal-associated protein 29", "Syntaxin-10", "Syntaxin-12", "Syntaxin-18", "Syntaxin-4", "Syntaxin-5", "Syntaxin-6", "Syntaxin-7", "Syntaxin-8", "Syntaxin-binding protein 3", "Syntenin-1", "System A-like transporters", "T-complex protein 1 subunit alpha", "T-complex protein 1 subunit beta", "T-complex protein 1 subunit delta", "T-complex protein 1 subunit epsilon", "T-complex protein 1 subunit eta", "T-complex protein 1 subunit gamma", "T-complex protein 1 subunit theta", "T-complex protein 1 subunit zeta", "TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L", "TAIRE subfamily", "TAK1 subfamily", "TATA-binding protein-associated factor 2N", "TBC1 domain family member 10A", "TBC1 domain family member 10B", "TBC1 domain family member 13", "TBC1 domain family member 15", "TBC1 domain family member 4", "TBC1 domain family member 9B", "THO complex subunit 1", "THO complex subunit 2", "THO complex subunit 3", "THO complex subunit 4", "TK group", "TKL group", "TOPK family", "TP53-binding protein 1", "TRIO family", "TTK family", "Target of EGR1 protein 1", "Targeting protein for Xklp2", "Testin", "Testis-specific Y-encoded-like protein 1", "Tgf-beta-activated kinase 1 and map3k7-binding protein 1", "Thimet oligopeptidase", "Thioredoxin domain-containing protein 12", "Thioredoxin domain-containing protein 17", "Thioredoxin domain-containing protein 9", "Thioredoxin reductase 1, cytoplasmic", "Thioredoxin-dependent peroxide reductase, mitochondrial", "Threonine--tRNA ligase, cytoplasmic", "Threonine--tRNA ligase, mitochondrial", "Thymidine kinase family", "Thymidine kinase, cytosolic", "Thymidylate kinase", "Thymidylate kinase family", "Thymidylate synthase", "Thyroid hormone receptor-associated protein 3", "Tight junction", "Tight junction protein ZO-1", "Tight junction protein ZO-2", "Torsin-1A", "Torsin-1B", "Trans-Golgi network integral membrane protein 2", "Transaminase", "Transcription activator BRG1", "Transcription cofactor", "Transcription elongation factor A protein 1", "Transcription elongation factor SPT6", "Transcription elongation regulator 1", "Transcription factor", "Transcription initiation factor IIB", "Transcriptional activator protein Pur-alpha", "Transcriptional repressor CTCF", "Transcriptional repressor p66-alpha", "Transcriptional repressor p66-beta", "Transferase", "Transferrin receptor protein 1", "Transformer-2 protein homolog alpha", "Transformer-2 protein homolog beta", "Transforming protein RhoA", "Transgelin-2", "Transketolase", "Translation elongation factor", "Translation factor", "Translation factor GUF1, mitochondrial", "Translation initiation factor", "Translation release factor", "Translationally-controlled tumor protein", "Translocation protein SEC63 homolog", "Translocon-associated protein subunit alpha", "Transmembrane 9 superfamily member 2", "Transmembrane 9 superfamily member 3", "Transmembrane 9 superfamily member 4", "Transmembrane emp24 domain-containing protein 10", "Transmembrane emp24 domain-containing protein 2", "Transmembrane emp24 domain-containing protein 4", "Transmembrane emp24 domain-containing protein 5", "Transmembrane emp24 domain-containing protein 7", "Transmembrane emp24 domain-containing protein 9", "Transport and Golgi organization protein 1 homolog", "Transporter", "Transportin-1", "Transportin-3", "Tricarboxylate transport protein, mitochondrial", "Trifunctional enzyme subunit alpha, mitochondrial", "Trifunctional enzyme subunit beta, mitochondrial", "Trifunctional purine biosynthetic protein adenosine-3", "Triosephosphate isomerase", "Tripeptidyl-peptidase 1", "Tripeptidyl-peptidase 2", "Triple functional domain protein", "Trophoblast glycoprotein", "Tropomodulin-3", "Tropomyosin alpha-1 chain", "Tropomyosin alpha-3 chain", "Tropomyosin alpha-4 chain", "Tryptophan--tRNA ligase, cytoplasmic", "Tuberin", "Tubulin", "Tubulin beta chain", "Tubulin beta-2A chain", "Tubulin beta-2B chain", "Tubulin beta-4A chain", "Tubulin beta-4B chain", "Tubulin beta-6 chain", "Tubulin gamma-1 chain", "Tubulin-folding cofactor B", "Tubulin-specific chaperone A", "Tubulin-specific chaperone D", "Tubulin-specific chaperone E", "Tudor domain", "Tumor susceptibility gene 101 protein", "Twinfilin-1", "Twinfilin-2", "Twinkle protein, mitochondrial", "Type II PI4K subfamily", "Type III PI4K subfamily", "Tyrosine--tRNA ligase, cytoplasmic", "Tyrosine--tRNA ligase, mitochondrial", "Tyrosine-protein kinase csk", "U1 small nuclear ribonucleoprotein 70 kDa", "U1 small nuclear ribonucleoprotein A", "U2 small nuclear ribonucleoprotein A'", "U2 small nuclear ribonucleoprotein B''", "U2 snRNP-associated SURP motif-containing protein", "U3 small nucleolar RNA-associated protein 14 homolog A", "U3 small nucleolar RNA-associated protein 6 homolog", "U3 small nucleolar ribonucleoprotein protein IMP3", "U3 small nucleolar ribonucleoprotein protein MPP10", "U4/U6 small nuclear ribonucleoprotein Prp3", "U4/U6 small nuclear ribonucleoprotein Prp31", "U4/U6 small nuclear ribonucleoprotein Prp4", "U4/U6.U5 tri-snRNP-associated protein 1", "U4/U6.U5 tri-snRNP-associated protein 2", "U6 snRNA-associated Sm-like protein LSm2", "U6 snRNA-associated Sm-like protein LSm4", "U6 snRNA-associated Sm-like protein LSm6", "UDP-glucose:glycoprotein glucosyltransferase 1", "UMP-CMP kinase", "UV excision repair protein RAD23 homolog A", "UV excision repair protein RAD23 homolog B", "Ubiquitin carboxyl-terminal hydrolase 10", "Ubiquitin carboxyl-terminal hydrolase 11", "Ubiquitin carboxyl-terminal hydrolase 14", "Ubiquitin carboxyl-terminal hydrolase 15", "Ubiquitin carboxyl-terminal hydrolase 19", "Ubiquitin carboxyl-terminal hydrolase 28", "Ubiquitin carboxyl-terminal hydrolase 33", "Ubiquitin carboxyl-terminal hydrolase 47", "Ubiquitin carboxyl-terminal hydrolase 5", "Ubiquitin carboxyl-terminal hydrolase 7", "Ubiquitin carboxyl-terminal hydrolase isozyme L5", "Ubiquitin conjugation factor E4 A", "Ubiquitin thioesterase OTUB1", "Ubiquitin-conjugating enzyme E2 L3", "Ubiquitin-like modifier-activating enzyme 1", "Ubiquitin-like modifier-activating enzyme 5", "Ubiquitin-like modifier-activating enzyme 6", "Ubiquitin-like-conjugating enzyme ATG3", "Ubiquitin-protein ligase", "Unclassified protein", "Unconventional myosin-Ib", "Unconventional myosin-Ic", "Unconventional myosin-Id", "Unconventional myosin-VI", "Upstream-binding protein 1", "Uridine kinase family", "Uridine-cytidine kinase 2", "V-type ATPase", "V-type proton ATPase 116 kDa subunit a isoform 1", "V-type proton ATPase 116 kDa subunit a isoform 2", "V-type proton ATPase catalytic subunit A", "V-type proton ATPase subunit B, brain isoform", "V-type proton ATPase subunit C 1", "V-type proton ATPase subunit H", "V-type proton ATPase subunit d 1", "VRK family", "Vacuolar protein sorting-associated protein 18 homolog", "Vacuolar protein sorting-associated protein 26A", "Vacuolar protein sorting-associated protein 26B", "Vacuolar protein sorting-associated protein 29", "Vacuolar protein sorting-associated protein 33A", "Vacuolar protein sorting-associated protein 33B", "Vacuolar protein sorting-associated protein 35", "Vacuolar protein sorting-associated protein 4A", "Vacuolar protein sorting-associated protein 4B", "Vacuole membrane protein 1", "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial", "Very-long-chain enoyl-CoA reductase", "Vesicle coat protein", "Vesicle-associated membrane protein 7", "Vesicle-associated membrane protein-associated protein A", "Vesicle-associated membrane protein-associated protein B/C", "Vesicle-fusing ATPase", "Vesicular integral-membrane protein VIP36", "Vitamin K epoxide reductase complex subunit 1-like protein 1", "WD repeat-containing protein 1", "WD repeat-containing protein 74", "WD repeat-containing protein 82", "WEE family", "Writer", "X-ray repair cross-complementing protein 5", "X-ray repair cross-complementing protein 6", "Xaa-Pro dipeptidase", "YLP motif-containing protein 1", "YSK subfamily", "ZZ-type zinc finger-containing protein 3", "Zinc finger CCCH domain-containing protein 11A", "Zinc finger CCCH domain-containing protein 15", "Zinc finger CCCH domain-containing protein 7B", "Zinc finger CCHC domain-containing protein 8", "Zinc finger MYM-type protein 2", "Zinc finger MYM-type protein 4", "Zinc finger RNA-binding protein", "Zinc finger protein 281", "Zinc finger protein ubi-d4", "Zinc finger transcription factor", "Zinc transporter 5", "Zinc transporter 9", "Zinc transporter ZIP14", "Zyxin", "[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial", "[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial", "[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial", "c-Myc-binding protein", "eIF-2-alpha kinase activator GCN1", "eukaryotic two domain clade \"e\" sub-subfamily", "m7GpppX diphosphatase", "mRNA export factor", "mRNA polyadenylation factor", "mRNA processing factor", "mRNA splicing factor", "mRNA-decapping enzyme 1B", "rRNA 2'-O-methyltransferase fibrillarin", "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6", "tRNA (cytosine(34)-C(5))-methyltransferase", "tRNA (guanine-N(7)-)-methyltransferase", "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4", "tRNA pseudouridine synthase A"], "available_proteins": ["AARS", "AARS2", "AARSD1", "AASDHPPT", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCF1", "ABCF2", "ABCF3", "ABHD12", "ACAA1", "ACAA2", "ACAD11", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTR10", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADPGK", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AHCY", "AHCYL1", "AIFM1", "AIMP1", "AIP", "AK1", "AK2", "AK4", "AKAP1", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG1", "ALG12", "ALG9", "ALYREF", "ANAPC1", "ANO6", "ANP32B", "ANP32E", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APEH", "ARCN1", "ARFIP1", "ARG2", "ARHGDIA", "ARID4B", "ARIH1", "ARIH2", "ARPC1A", "ARPC1B", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASF1A", "ASH2L", "ASNA1", "ASNS", "ASRGL1", "ATAD2", "ATAD3A", "ATAD3B", "ATG3", "ATG4B", "ATIC", "ATL2", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP6", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1H", "ATP7A", "ATP7B", "ATPAF1", "ATPIF1", "ATXN2", "ATXN2L", "AUP1", "AURKA", "BAG6", "BAIAP2", "BCAP31", "BCAS2", "BCKDK", "BCLAF1", "BLMH", "BLOC1S1", "BLVRA", "BLVRB", "BOP1", "BPNT1", "BRCA1", "BRD2", "BRD3", "BRD4", "BRD7", "BRIX1", "BUB1B", "BUB3", "BUD23", "BUD31", "BZW1", "BZW2", "CAB39", "CACYBP", "CAD", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD276", "CD2BP2", "CDC37", "CDC42", "CDK1", "CDK12", "CDK16", "CDK2", "CDK4", "CDK5", "CDK7", "CDK9", "CDKN2AIP", "CEBPZ", "CEP170", "CETN2", "CFAP20", "CHAF1A", "CHAF1B", "CHEK2", "CHERP", "CHKA", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHRAC1", "CHST14", "CIRBP", "CKAP5", "CKB", "CKMT1A*", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLNS1A", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT3", "CNOT7", "CNP", "COASY", "COIL", "COLEC12", "COLGALT1", "COMT", "COMTD1", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS3", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX2", "COX5A", "COX5B", "COX7A2", "COX7A2L", "COX7C", "CPOX", "CPSF1", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRNKL1", "CRTAP", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK1E", "CSNK2A2", "CSNK2B", "CSTB", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNND1", "CTPS1", "CTPS2", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL4B", "CUL5", "CYB5B", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DBT", "DCAF13", "DCP1B", "DCPS", "DCTN1", "DCTN2", "DDAH2", "DDB1", "DDI2", "DDOST", "DENR", "DERL1", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHX15", "DHX29", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DICER1", "DIDO1", "DIEXF", "DIS3", "DLD", "DLG1", "DLGAP5", "DLST", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DOLPP1", "DPF2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DSG2", "DSP", "DST", "DTYMK", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC4", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EEFSEC", "EFHD2", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHHADH", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3H", "EIF3I", "EIF3J", "EIF3L", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELMO2", "ELMOD2", "ELOB", "ELOC", "ELP1", "ELP3", "EMC2", "EMG1", "ENO1", "ENO2", "EPHA7", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERH", "ERMP1", "ERO1A", "ERP29", "ESD", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC4", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOSC1", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "FAHD1", "FAM177A1", "FARSB", "FASN", "FBL", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FKBP4", "FKBP5", "FNTA", "FNTB", "FOXRED1", "FRG1", "FSCN1", "FTL", "FUBP1", "FUBP3", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GCAT", "GCFC2", "GCLC", "GCN1", "GDI1", "GDI2", "GFPT1", "GGH", "GINS1", "GINS2", "GIPC1", "GLB1", "GLDC", "GLRX3", "GLRX5", "GLS", "GLTP", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAO1", "GNPDA1", "GNS", "GOLGA2", "GOSR1", "GOSR2", "GPAT4", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR89B", "GPT2", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GTF2B", "GTF2F2", "GTF2H4", "GTF3C3", "GTF3C5", "GTPBP1", "GUF1", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADHA", "HADHB", "HARS2", "HAT1", "HBS1L", "HCCS", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HEATR1", "HELZ", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMBS", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGN1", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HPRT1", "HSD17B10", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HTATSF1", "HUWE1", "IARS", "IARS2", "IDE", "IDH3A", "IDH3B", "IDI1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKG", "ILF3", "ILKAP", "ILVBL", "IMP3", "IMPAD1", "IMPDH1", "IMPDH2", "INTS11", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "ITGB1", "ITPA", "IVD", "KARS", "KAT7", "KCTD12", "KDELR1", "KDM1A", "KDM1B", "KDM3B", "KHDRBS1", "KHSRP", "KIF11", "KIF14", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRR1", "KYAT3", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS2", "LBR", "LDB1", "LDHA", "LDHB", "LETM1", "LGALS3", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LRRC47", "LRWD1", "LSM14B", "LSM2", "LSM4", "LSM6", "M6PR", "MACF1", "MAGED2", "MAGT1", "MAN1A1", "MAN1A2", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP3K7", "MAP7D1", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARCH5", "MARK2", "MAT2A", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDH1", "MDH2", "ME1", "ME2", "MECP2", "MED14", "METTL1", "MFAP1", "MFN2", "MFSD5", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIPEP", "MMS19", "MORF4L1", "MPC2", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRPL1", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL27", "MRPL38", "MRPL39", "MRPL41", "MRPL43", "MRPL44", "MRPL47", "MRPL48", "MRPL49", "MRPL9", "MRPS11", "MRPS2", "MRPS21", "MRPS27", "MRPS35", "MRPS5", "MRPS7", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTOR", "MTPAP", "MUT", "MYBBP1A", "MYCBP", "MYEF2", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA50", "NADK2", "NAE1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NBN", "NCAPD2", "NCBP1", "NCL", "NCOA5", "NCOR1", "ND5", "NDRG3", "NDUFA10", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA8", "NDUFA9", "NDUFB11", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS6", "NDUFS7", "NDUFS8", "NEDD4L", "NEK9", "NF1", "NFRKB", "NFS1", "NFXL1", "NHP2", "NIPBL", "NISCH", "NKRF", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOC4L", "NOL6", "NOM1", "NONO", "NOP10", "NOP14", "NOP56", "NOP58", "NOP9", "NPEPPS", "NPM1", "NRBP1", "NRDC", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE3", "NSUN2", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDCD2", "NUDCD3", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUP107", "NUP153", "NUP160", "NUP210", "NUP214", "NUP37", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCIAD1", "OCLN", "OCRL", "OLA1", "OMA1", "OPA1", "ORC2", "ORC3", "ORC5", "OSGEP", "OTUB1", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P3H4", "PACSIN2", "PACSIN3", "PAICS", "PAK2", "PAK4", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARL", "PARN", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PDCD11", "PDCD5", "PDCD6IP", "PDE12", "PDE6D", "PDHX", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDS5A", "PDS5B", "PDXK", "PEBP1", "PECR", "PEPD", "PES1", "PEX14", "PEX19", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PGD", "PGK1", "PGLS", "PGP", "PGRMC1", "PHAX", "PHC2", "PHF10", "PHF3", "PHF6", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PICALM", "PIGK", "PIK3C2A", "PIK3R2", "PINX1", "PIP4K2C", "PIR", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLS1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLD2", "POLDIP3", "POLE2", "POLE4", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR2L", "POLR3A", "POLR3C", "POLR3E", "POLRMT", "PPA1", "PPA2", "PPAT", "PPIL1", "PPM1F", "PPM1G", "PPME1", "PPP1CA", "PPP1CB", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4R1", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX6", "PREB", "PREP", "PRIM1", "PRKAA2", "PRKACA", "PRKAG1", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRPF3", "PRPF31", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2B", "PRRC2C", "PSIP1", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSPC1", "PSPH", "PTCD1", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPRF", "PUM1", "PURA", "PUS1", "PWP1", "PXMP2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "RAB3GAP2", "RABAC1", "RABGAP1", "RABGEF1", "RABGGTA", "RAC1", "RACGAP1", "RAD23A", "RAD23B", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANGAP1", "RAP2B", "RAPGEF2", "RASA1", "RAVER1", "RBBP6", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM26", "RBM27", "RBM3", "RBM4", "RBM7", "RBMX", "RBPJ", "RCL1", "RCN1", "RCN2", "RDH11", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REPS1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT2", "RIOK2", "RIPK1", "RNASEH2A", "RNH1", "RNPS1", "ROCK1", "ROCK2", "RPA1", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS27", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRAS2", "RRM1", "RRM2", "RRP7A", "RRS1", "RSF1", "RSL1D1", "RTCA", "S100A10", "S100A11", "S100A13", "SAE1", "SAP18", "SAP30BP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SBNO1", "SC5D", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCFD1", "SCML2", "SCO1", "SCO2", "SCPEP1", "SCYL2", "SDCBP", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC13", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B3", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SHMT1", "SHMT2", "SIN3A", "SIN3B", "SIRT1", "SIRT2", "SKP1", "SLC12A2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC2A8", "SLC30A5", "SLC30A9", "SLC35B2", "SLC35F2", "SLC38A1", "SLC39A14", "SLC3A2", "SLC44A1", "SLC4A7", "SLC7A1", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMN1*", "SNAP23", "SNAP29", "SND1", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SOAT1", "SOD2", "SORD", "SPAG9", "SPCS2", "SPCS3", "SPTLC1", "SPTLC2", "SQLE", "SREK1", "SRM", "SRP14", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPRA", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "STAG1", "STAG2", "STAMBP", "STAT1", "STAT3", "STK26", "STK38", "STK4", "STOML2", "STRBP", "STT3A", "STT3B", "STX10", "STX12", "STX18", "STX4", "STX5", "STX6", "STX7", "STX8", "STXBP3", "SUCLA2", "SUCLG2", "SUGP1", "SUGP2", "SUN1", "SUN2", "SUPT16H", "SUPT6H", "SURF4", "SURF6", "SUZ12", "SYNCRIP", "SYNGR2", "SYNJ2BP", "TAB1", "TAF15", "TAF6L", "TAGLN2", "TARS", "TARS2", "TBC1D10A", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TCEA1", "TCERG1", "TCP1", "TECR", "TES", "TFCP2", "TFRC", "TGOLN2", "THOC1", "THOC2", "THOC3", "THOP1", "THRAP3", "TJP1", "TJP2", "TK1", "TKT", "TM9SF2", "TM9SF3", "TM9SF4", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM97", "TMOD3", "TMPO", "TNPO1", "TNPO3", "TOE1", "TOMM20", "TOMM40", "TOP1", "TOR1A", "TOR1B", "TP53", "TP53BP1", "TPBG", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAP1", "TRIO", "TRIP4", "TRMT6", "TROVE2", "TRUB1", "TSC2", "TSFM", "TSG101", "TSPYL1", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBG1", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC9", "TXNRD1", "TYMS", "U2AF1", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBE2L3", "UBE4A", "UBP1", "UCHL5", "UCK2", "UGGT1", "UNC119B", "UPF1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP28", "USP33", "USP39", "USP47", "USP5", "USP7", "UTP11", "UTP14A", "UTP3", "UTP6", "VAMP7", "VAPA", "VAPB", "VBP1", "VKORC1L1", "VMP1", "VPS18", "VPS26A", "VPS26B", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4A", "VPS4B", "VRK1", "VRK3", "WARS", "WDR1", "WDR4", "WDR74", "WDR82", "WIZ", "XAB2", "XPA", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "YARS", "YARS2", "YLPM1", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H15", "ZC3H7B", "ZCCHC8", "ZFR", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZNF207", "ZNF281", "ZNF598", "ZW10", "ZYX", "ZZZ3"], "leading_proteins": ["ABCB1", "ABCB7", "ACAT2", "ACOX1", "ACP2", "ACP6", "ADA", "AFG3L2", "AIFM1", "ALDH1B1", "ALG1", "ALG12", "ALG9", "ANO6", "ASAH1", "ATAD3A", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5B", "ATP5F1", "ATP5H", "ATP5I", "ATP6", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP7A", "ATP7B", "AUP1", "BAIAP2", "BCAP31", "CALU", "CBX3", "CBX5", "CDK1", "CETN2", "CLCN3", "CLPTM1L", "COPS8", "COX2", "COX5A", "COX7A2", "CPT1A", "CPT2", "CPVL", "CTSA", "CYB5B", "CYP51A1", "DAG1", "DERL1", "DHCR24", "DHFR", "DHODH", "DLD", "DOLPP1", "ECE1", "ELMOD2", "EPHA7", "ERAP1", "ETFDH", "EXOC7", "FAM177A1", "FDPS", "FECH", "FNTA", "FOXRED1", "GALNT1", "GAPVD1", "GLB1", "GLTP", "GM2A", "GNS", "GOSR1", "GPAT4", "GPX8", "HEXA", "HM13", "HSP90AA1", "HSP90B1", "IGF2R", "IMPAD1", "KDELR1", "KPNA2", "L2HGDH", "LAMP1", "LAMP2", "LETM1", "LIPA", "LMAN1", "LMAN2", "LNPEP", "LPCAT1", "M6PR", "MAGT1", "MAPK14", "MAPK3", "MCL1", "MCU", "MFAP1", "MIA2", "MIA3", "MPV17L2", "MSMO1", "MTCH1", "MTCH2", "NAMPT", "NAP1L1", "NAP1L4", "NDUFA13", "NDUFB11", "NDUFB4", "NDUFB8", "NDUFB9", "NNT", "NPEPPS", "NT5C3B", "NUCB1", "NUCB2", "NUP210", "NUP37", "NUP54", "NUP88", "NUP93", "OMA1", "OXA1L", "P3H1", "P3H4", "PARL", "PDE6D", "PDK1", "PDK3", "PECR", "PEX14", "PEX19", "PGRMC1", "PI4K2A", "PIGK", "PITRM1", "PLA2G15", "PLBD2", "PM20D2", "PMPCA", "PPT1", "PPT2", "PRCP", "PTGES2", "PTGR2", "PXMP2", "QSOX2", "RABAC1", "RABGEF1", "RAPGEF2", "RCN2", "REEP4", "REEP5", "SC5D", "SCARB1", "SCARB2", "SCO1", "SCO2", "SCPEP1", "SDCBP", "SDHB", "SEH1L", "SET", "SFXN1", "SFXN2", "SLC12A2", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC2A8", "SLC30A5", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC44A1", "SLC4A7", "SLC7A1", "SMARCC2", "SMN1*", "SNAP29", "SNX2", "SQLE", "SSR1", "STT3A", "STX10", "STX12", "STX18", "STX4", "STX5", "STX6", "STX7", "STX8", "SURF4", "SYNGR2", "SYNJ2BP", "TBC1D10A", "TFRC", "TGOLN2", "TM9SF2", "TM9SF3", "TM9SF4", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM97", "TOMM20", "TOMM40", "TPBG", "TPP1", "TRAP1", "TUBB", "TUBB2A", "TUBB2B", "TUBB4B", "TUBB6", "UNC119B", "UQCR10", "UQCRB", "UQCRC2", "VKORC1L1", "VMP1", "VPS18", "XPO4", "ZMPSTE24"]} \ No newline at end of file diff --git a/pharos_protein_category/advanced/idx2term.json b/pharos_protein_category/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/pharos_protein_category/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/pharos_protein_category/basic/idx2term.json b/pharos_protein_category/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..c2c9a89814544d67cab453c74790749979179bf3 --- /dev/null +++ b/pharos_protein_category/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Tclin"} \ No newline at end of file diff --git a/pharos_protein_category/basic/plot_0.png b/pharos_protein_category/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..a0ae3e66f39510d785dad4eba03c321b63d1fc38 --- /dev/null +++ b/pharos_protein_category/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:fc65adb9d3b4e5fe3ce3849a046a2cd13785e537eae50306b69a4030050a91ec +size 133118 diff --git a/pharos_protein_category/consensus.joblib b/pharos_protein_category/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..bb4e97134052a70dc855677bb0857441bec995ba --- /dev/null +++ b/pharos_protein_category/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:1f0caa2c02cd8b168927727728372fcadee86ca0e8b0a454940637dd4d26d723 +size 68720 diff --git a/pharos_protein_category/df_merge.tsv b/pharos_protein_category/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/pharos_protein_category/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/pharos_protein_category/metrics.json b/pharos_protein_category/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..082112dd831f9aacb052b06f1aa9d282a889e39a --- /dev/null +++ b/pharos_protein_category/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3120, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 779.75 +} \ No newline at end of file diff --git a/pharos_protein_category/paths.json b/pharos_protein_category/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..51a9e3d42844fbd522014022b688b20d0d74b16e --- /dev/null +++ b/pharos_protein_category/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_protein_category/fragment/C390/C390_val_log2fc"} \ No newline at end of file diff --git a/pharos_protein_category/result.tsv b/pharos_protein_category/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..a54d1bba04f7ea43a8ea8fb16ff8191975cb2f89 --- /dev/null +++ b/pharos_protein_category/result.tsv @@ -0,0 +1,2 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Tclin 0.4154626201828447 1.806750885014041 0.0708011298118118 0.2545222387969704 0.2832045192472474 88 P28074,Q99720,P49721,Q9P0J0,Q02127,P06280,O95169,Q86Y39,O96000,P00374,P05023,P07437,P00813,Q9Y6M9,O43924,P21964,Q13885,Q9BVA1,P10253,O95168,P38435,P68371 22 diff --git a/pharos_protein_category/selections.json b/pharos_protein_category/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..2e0ad18a8a4c952b1000c2be7290e19ec3e4eb99 --- /dev/null +++ b/pharos_protein_category/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Tbio", "Tchem", "Tclin", "Tdark"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGFG1", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "AKT2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALG9", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD13A", "ANLN", "ANO10", "ANO6", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APC", "APEH", "APEX1", "API5", "APMAP", "APOO", "APOOL", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARG2", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID4B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARL6", "ARL6IP1", "ARL6IP5", "ARL8B", "ARMC1", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC1", "ASCC2", "ASCC3", "ASF1A", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATG13", "ATG3", "ATG4B", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATP7B", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BABAM2", "BAG2", "BAG5", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS2", "BCCIP", "BCKDK", "BCL10", "BCL2L13", "BCLAF1", "BCS1L", "BEND3", "BICD2", "BIRC6", "BLMH", "BLOC1S1", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BRAP", "BRAT1", "BRCA1", "BRD1", "BRD2", "BRD3", "BRD4", "BRD7", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf43", "C12orf73", "C17orf75", "C19orf25", "C19orf70", "C1QBP", "C1orf122", "C1orf123", "C1orf35", "C2CD5", "C5orf15", "C7orf50", "C8orf33", "CAB39", "CACYBP", "CAD", "CALCOCO1", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAMSAP3", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CC2D1A", "CCAR1", "CCAR2", "CCDC12", "CCDC124", "CCDC127", "CCDC138", "CCDC22", "CCDC47", "CCDC6", "CCDC8", "CCDC86", "CCDC93", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CCZ1B", "CD276", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK16", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK5RAP2", "CDK5RAP3", "CDK7", "CDK9", "CDKAL1", "CDKN2AIP", "CDR2L", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPV", "CEP170", "CEP290", "CEP44", "CETN2", "CFAP20", "CFL1", "CFL2", "CGGBP1", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHEK2", "CHERP", "CHID1", "CHKA", "CHMP1A", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHP1", "CHRAC1", "CHST14", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT3", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COASY", "COG3", "COG4", "COG7", "COG8", "COIL", "COLEC12", "COLGALT1", "COMMD1", "COMMD4", "COMMD7", "COMT", "COMTD1", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "COQ8A", "CORO1C", "COTL1", "COX11", "COX14", "COX15", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7A2L", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK1E", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CTTNBP2NL", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUL7", "CUTA", "CWF19L1", "CXADR", "CXorf56", "CXorf57", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAG1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCP1B", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D5", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DERL1", "DFFA", "DGCR8", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DR1", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUS2", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYM", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFHD2", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHHADH", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC3", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC4", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120A", "FAM129B", "FAM162A", "FAM177A1", "FAM208A", "FAM208B", "FAM210A", "FAM213A", "FAM3C", "FAM49B", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD2", "FAU", "FBL", "FBXO22", "FBXO7", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FKRP", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FNBP1", "FNBP4", "FNDC3A", "FNTA", "FNTB", "FOXK1", "FOXK2", "FOXRED1", "FRG1", "FSCN1", "FTL", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLC", "GCN1", "GDAP1", "GDE1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GGH", "GGPS1", "GHDC", "GHITM", "GID4", "GIGYF2", "GINS1", "GINS2", "GINS3", "GINS4", "GIPC1", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLTP", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAO1", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLPH3", "GOLT1B", "GORASP2", "GOSR1", "GOSR2", "GOT1", "GOT2", "GPAT4", "GPATCH4", "GPATCH8", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR89B", "GPRASP2", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2H4", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD2", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAT1", "HAUS1", "HAUS2", "HAUS4", "HAUS5", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCR", "HMGCS1", "HMGN1", "HMGXB4", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IFT88", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKG", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INCENP", "INF2", "INPP4A", "INTS1", "INTS10", "INTS11", "INTS12", "INTS14", "INTS3", "INTS8", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "IRF2BPL", "IRGQ", "IRS4", "ISCU", "ISOC1", "IST1", "ISYNA1", "ITGAV", "ITGB1", "ITPA", "ITPRIP", "IVD", "IWS1", "JAGN1", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1468", "KIAA2013", "KIF11", "KIF14", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC4", "KLHDC4", "KNOP1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LCMT2", "LDAH", "LDB1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC57", "LRRC59", "LRRC8C", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM4", "LSM6", "LSS", "LTA4H", "LTV1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LYPLA2", "LYRM2", "LZIC", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MAN1A1", "MAN1A2", "MAN2A1", "MANF", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4", "MAP7D1", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARK2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED16", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METAP2", "METTL1", "METTL13", "METTL3", "MFAP1", "MFF", "MFN2", "MFSD10", "MFSD5", "MFSD8", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIEF1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMGT1", "MMS19", "MOGS", "MORC2", "MORF4L1", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL27", "MRPL3", "MRPL33", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL45", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS17", "MRPS2", "MRPS21", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MUT", "MVD", "MXRA7", "MYBBP1A", "MYCBP", "MYCBP2", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAF1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCDN", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCOR1", "NCSTN", "ND5", "NDC1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB11", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS5", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFB", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NF1", "NFATC2IP", "NFRKB", "NFS1", "NFXL1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP2", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP10", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPHP3", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRM", "NRP1", "NSA2", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDCD3", "NUDT1", "NUDT16L1", "NUDT19", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "ODR4", "OGDH", "OGT", "OLA1", "OMA1", "OPA1", "OPA3", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP2", "PAK1IP1", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARL", "PARN", "PARP1", "PARP2", "PBDC1", "PBK", "PBRM1", "PBXIP1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDS5A", "PDS5B", "PDSS2", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PHAX", "PHB", "PHB2", "PHC2", "PHF10", "PHF3", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHPT1", "PI4K2A", "PI4KA", "PICALM", "PIGG", "PIGK", "PIGS", "PIGT", "PIH1D1", "PIK3C2A", "PIK3R2", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNMA8A", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLE4", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR2L", "POLR3A", "POLR3C", "POLR3E", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPFIA1", "PPHLN1", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R14B", "PPP1R9B", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRELID3B", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2B", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSMG1", "PSMG3", "PSPC1", "PSPH", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PTRHD1", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB34", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RABAC1", "RABEP1", "RABGAP1", "RABGEF1", "RABGGTA", "RABL3", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALGAPB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANGAP1", "RAP1GDS1", "RAP2B", "RAPGEF2", "RARS", "RASA1", "RAVER1", "RBBP5", "RBBP6", "RBFA", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM47", "RBM5", "RBM6", "RBM7", "RBM8A", "RBMX", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REPS1", "RER1", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT2", "RIDA", "RIF1", "RINT1", "RIOK2", "RIPK1", "RMDN1", "RMDN3", "RMND1", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF219", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPA3", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS27", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCA", "RTCB", "RTF1", "RTFDC1", "RTN1", "RTN2", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SBNO1", "SC5D", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCAP", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SCRN3", "SCYL2", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHCBP1", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIN3A", "SIN3B", "SIRT1", "SIRT2", "SKA3", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC2A8", "SLC30A5", "SLC30A9", "SLC35A4", "SLC35B2", "SLC35F2", "SLC38A1", "SLC39A14", "SLC3A2", "SLC44A1", "SLC4A1AP", "SLC4A7", "SLC7A1", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMG5", "SMG8", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNIP1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX2", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPDL1", "SPECC1L", "SPEN", "SPR", "SPRYD7", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRFBP1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR3", "SSR4", "SSRP1", "ST3GAL4", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK26", "STK38", "STK4", "STMN1", "STOML2", "STRAP", "STRBP", "STRIP1", "STRN", "STT3A", "STT3B", 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0.2998011899649158 0.1839797061852897 1.0 1.0 1.0 0.2531867173469597 +Steroid metabolism 10 28 1.9712003941733127 0.0487009588628244 7.703883495145631 26.439320388349515 1.128083592407629 0.3052190273048834 3.279782799169419 3.1412859163137186 1.216134343451914 0.3162944576553002 0.0012630411907842 1.0 1.0 0.0432632841258681 5.412109352262341e-05 diff --git a/protein_atlas_biological_process/metrics.json b/protein_atlas_biological_process/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..3c79008b2a438e1eb303f261958c08abcc36519b --- /dev/null +++ b/protein_atlas_biological_process/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3120, + "annotations_size": 167, + "title": "Average number of proteins per term", + "value": 30.293413173652695 +} \ No newline at end of file diff --git a/protein_atlas_biological_process/paths.json b/protein_atlas_biological_process/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..75e6635a838b477b6b01ae7d2d72de847cdde7aa --- /dev/null +++ b/protein_atlas_biological_process/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_biological_process/fragment/C390/C390_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_biological_process/result.tsv b/protein_atlas_biological_process/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..3013b3e46ab6edd4f89b2e3f2cee4c531f4d149a --- /dev/null +++ b/protein_atlas_biological_process/result.tsv @@ -0,0 +1,43 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Ion transport 0.6365028337163804 3.9355557480219425 8.30043929713753e-05 0.0137666695832543 0.0138617336262198 55 Q9Y487,P0CG08,P20020,Q9UM00,Q04656,Q9Y277,P55011,P21796,O95202,Q8NE01,O75964,Q8TDW0,P05026,O75947,P16615,P98194,P24539,P36542,P45880,P23634,Q8TAD4,P00846,Q15904,Q9BVC6,P05023,Q15043,P06576,Q6P4Q7,P35670,Q93050,P56385,Q8NE86,Q9BPX6,P36543,Q9H0H5,Q14847,P54709,O96008,Q4KMQ2,P51790,Q9Y6M7 41 +Respiratory chain 0.6166071616175849 3.163714611674332 0.0015576945853361 0.229208840555695 0.0814426222907514 34 O95169,P14927,Q86Y39,P22695,Q9P0J0,Q96CU9,Q9Y6M9,Q9UDW1,O96000,O14949,O95168,P00403 12 +Electron transport 0.5729381435568695 3.0976340513316485 0.001950721491994 0.2782587954058738 0.0814426222907514 47 Q9H3N1,O95169,P14927,Q86Y39,P22695,Q9P0J0,Q96CU9,Q9Y6M9,Q9UDW1,Q9H1E5,P21912,O96000,Q9NX14,O14949,O95168,O43169,P00403,Q6DKK2 18 +Hydrogen ion transport 0.656481606964192 2.723460682933944 0.0064601904524987 0.6612021563921591 0.1458833719871637 19 Q9Y487,P24539,Q93050,P56385,P00846,O75964,Q15904 7 +Phospholipid metabolism 0.7188810377030541 2.6406433742423157 0.0082748771839169 0.750339622088849 0.1458833719871637 14 Q96N66,Q8NF37,P35790,O95674,Q9UG56,Q9NPH0,Q9BVG9 7 +Calcium transport 0.8114052905460856 2.6034422356972087 0.009229281877646 0.7874220727121194 0.1458833719871637 9 P16615,P98194,P20020,Q9UM00,P23634,O95202,Q9BPX6 7 +Sphingolipid metabolism 0.8097594292780814 2.48794876450507 0.0128482241312679 0.8846237282474412 0.1458833719871637 8 P17900,Q13510,O95470,Q06136,P04062,O15269 6 +Phospholipid biosynthesis 0.6916894249892889 2.3898920129507437 0.0168533273122857 0.9414861874327924 0.1655591565383362 13 Q96N66,Q8NF37,P35790,O95674,Q9UG56,Q9BVG9 6 +ATP synthesis 0.7456814363019736 2.17966008214588 0.0292826675792743 0.9930097138970762 0.222188896416071 8 P56385,P00846,O75964 3 +Sensory transduction 0.7703592878337017 2.117413152965367 0.0342247988758512 0.99701942351175 0.222188896416071 7 Q9H6K4,P50897,O43924 3 +Vision 0.7703592878337017 2.117413152965367 0.0342247988758512 0.99701942351175 0.222188896416071 7 Q9H6K4,P50897,O43924 3 +Sterol metabolism 0.5142264009117317 2.064906006342485 0.0389318946821966 0.9986819086714896 0.2322009432831011 27 P04035,O75477,Q15738,O15118,Q16850,Q15800,O94905,P14324,Q15392,P04062,P37268,P00387,Q12770,O75845 14 +Cholesterol metabolism 0.5200333433484022 2.0329487435806866 0.0420577017181187 0.9992349823267024 0.2341212062308609 25 P04035,O75477,Q15738,O15118,Q16850,Q15800,O94905,P14324,Q15392,P04062,P37268,P00387,Q12770 13 +Antiport 0.7675016056518912 1.9843159745467904 0.0472206264551628 0.9996897427836894 0.2464326443128813 6 P12236,P41440,P12235,P51790,O95202 5 +Steroid metabolism 0.497430869908996 1.9712003941733132 0.0487009588628244 0.99976069660891 0.2464563675785357 28 P04035,O15118,Q16850,Q15800,O94905,P04062,Q15392,P37268,Q12770,O75845 10 +ER-Golgi transport 0.4421024701860052 1.9450214639119576 0.0517723950596791 0.9998605548972368 0.2513761045213921 50 Q15363,Q9P2W9,O95249,Q9Y282,P49755,O95070,O95197,P24390 8 +Translocation 0.4449727066712129 1.906133562181056 0.056632879268772 0.9999408870196704 0.2627136343856924 47 Q8NFH4,O75381,Q8NFH5,O14925,Q9NS69,Q99442,P41208,Q7Z3B4,Q9Y5J9,Q3ZCQ8,Q8TD16,Q9BTX1,Q8N1F7,Q15629,O43615,O60830 16 +Amino-acid transport 0.7152579750319904 1.8555276765852464 0.0635209107509413 0.999982614783794 0.2791576867212422 7 Q6P4A7,P08195,Q9H9B4,P30825,Q96NB2 5 +Steroid biosynthesis 0.4982667378095832 1.7700392536720717 0.0767206018260824 0.999998375816092 0.3203085126238941 22 Q53GQ0,Q14739,P04035,Q15738,Q16850,Q15800,P14324,Q15392,P37268,P00387,O75845 11 +Sodium transport 0.6777343378400673 1.5637254364032822 0.1178820615209965 0.9999999992002556 0.3714397032831401 6 P05026,P05023,P54709,Q9Y6M7 4 +Cell adhesion 0.4361643736491927 1.4945903671713174 0.1350213816744008 0.9999999999698076 0.3731174857112858 29 Q96GC9,Q08722,P00813,Q08380 4 +Notch signaling pathway 0.6622829672837818 1.4897559287765108 0.1362884229244816 0.9999999999763636 0.3731174857112858 6 Q9UBV2 1 +Potassium transport 0.7474326059050092 1.4625177534411928 0.143599382972976 0.9999999999942843 0.3747046399451093 4 P05026,P05023,P54709 3 +Sterol biosynthesis 0.4924284021824902 1.4525072747983645 0.146360607874409 0.999999999996667 0.3760341771542509 17 P04035,Q15738,Q16850,Q15800,P14324,Q15392,P37268,P00387,O75845 9 +Lipid transport 0.4718282247064728 1.4426318989800504 0.1491241924928252 0.9999999999980608 0.3773293961560882 19 Q99720,O15118,Q9BUR5 3 +GPI-anchor biosynthesis 0.7406931964056306 1.433514950682874 0.1517107294277724 0.9999999999988336 0.3781446539468357 4 Q5H8A4,Q92643,Q96S52 3 +Cholesterol biosynthesis 0.4995605137766338 1.382571406704289 0.1667963214652175 0.9999999999999416 0.3979283669241618 15 P04035,Q15738,Q16850,Q15800,P14324,Q15392,P37268,P00387 8 +Copper transport 0.8726747915330345 1.2704320630502226 0.2039307681959257 1.0 0.452997432128203 2 P35670 1 +Autophagy 0.3875912084096525 1.1831010933989508 0.2367690845771701 1.0 0.4930620771701034 34 Q9H0U4,Q9UHD9,Q8IXJ6,P13473,Q9Y6I9,Q96GC9,Q9Y371,O95721,Q9P253,Q969Q5 10 +Zinc transport 0.8079234235637653 1.0859920612796896 0.2774825045312377 1.0 0.5388323053106593 3 Q8TAD4 1 +Leukotriene biosynthesis 0.8159076330981396 1.0383039093970887 0.2991285892105138 1.0 0.5612862291927618 2 P09960 1 +Apoptosis 0.3815052692090891 1.0193878257430369 0.30801888354353 1.0 0.565880935463349 120 Q15375,Q96A26,Q96KA5,Q9Y3E5,Q9P0J0,Q15041,P21796,Q14728,Q01085,P31751,Q6NUQ4,Q13501,Q9Y3E7,Q9H2J4,Q5J8M3,Q14185,O95197,O43464,Q9NR28,Q9Y2J2,O95831,O60313,P51572,Q96TC7,Q9NZJ7,Q07820,P61289,Q12981,P12236,Q9UDX5,O14737,O95470,Q9BXK5,Q9Y371,Q9UHX1,Q9H3K2,P52756,P09601,P46379,O95140,Q96HE7 41 +Symport 0.545366128587175 1.007888410492313 0.3135080360198798 1.0 0.5690852392969559 7 Q9H936,Q9Y6M7,Q15758 3 +Phagocytosis 0.6381322314641636 0.991357680222965 0.3215109571121797 1.0 0.5773368799756345 4 Q96JJ3,Q14185 2 +Heme biosynthesis 0.5392674359488152 0.976882722887162 0.3286272160887922 1.0 0.5838377136896628 7 P22830 1 +Sodium/potassium transport 0.7587423804940618 0.8977130072691674 0.3693385730990193 1.0 0.6295455453857913 3 P05026,P05023 2 +Unfolded protein response 0.4812551786704372 0.8637320231087939 0.3877351177799175 1.0 0.641106580883626 9 Q13217,Q15629,Q9BUN8,O95140 4 +Sugar transport 0.731045966113515 0.7942042536866171 0.4270765325933756 1.0 0.6665587004027451 3 Q9NY64 1 +Lipid metabolism 0.3602329364893755 0.7243216549584005 0.4688682854241317 1.0 0.7054144474399099 123 Q13011,Q9H7Z7,Q9UG56,Q9NPH0,O15118,P04062,Q06136,Q15392,O15269,Q8N2A8,P23786,Q12770,P50416,Q96N66,Q8NF37,A1L0T0,Q13510,P04035,O75477,P51648,Q9BVG9,Q11206,Q8NHP8,P35790,O95674,P17900,Q9P035,Q9BY49,Q9H6V9,O94905,P37268,O75845,P38571,O95470,Q8NCG7,Q16850,Q15800,O00116,Q8NCC3,Q15067,Q53GQ0 41 +Nucleotide metabolism 0.4197339722861124 0.5295975099345274 0.5963910211766186 1.0 0.7679000983896713 9 P00813 1 +Stress response 0.3178615247138362 0.4419459132039773 0.6585283452901871 1.0 0.8106518252559416 29 Q13217,Q14011,O95433,O95197,P98179 5 +Tetrahydrobiopterin biosynthesis 0.5048107761385464 0.1052448362017943 0.9161815341042354 1.0 0.9782457952261692 2 P61457 1 diff --git a/protein_atlas_biological_process/selections.json b/protein_atlas_biological_process/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f2e6d469596067a2b4ea738ca739784df5ebc2a2 --- /dev/null +++ b/protein_atlas_biological_process/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthesis", "Adaptive immunity", "Amino-acid biosynthesis", "Amino-acid transport", "Angiogenesis", "Antiport", "Antiviral defense", "Apoptosis", "Arginine metabolism", "Aromatic hydrocarbons catabolism", "Asparagine biosynthesis", "Autophagy", "Behavior", "Biological rhythms", "Biomineralization", "Branched-chain amino acid catabolism", "Calcium transport", "Carbohydrate metabolism", "Carnitine biosynthesis", "Catecholamine metabolism", "Cell adhesion", "Cell cycle", "Cell division", "Cell shape", "Chemotaxis", "Cholesterol biosynthesis", "Cholesterol metabolism", "Chromosome partition", "Cilium biogenesis/degradation", "Coenzyme A biosynthesis", "Collagen degradation", "Complement pathway", "Copper transport", "DNA condensation", "DNA damage", "DNA excision", "DNA recombination", "DNA repair", "DNA replication", "DNA synthesis", "Detoxification", "Differentiation", "ER-Golgi transport", "Electron transport", "Endocytosis", "Erythrocyte maturation", "Exocytosis", "Fatty acid biosynthesis", "Fatty acid metabolism", "Fertilization", "Fucose metabolism", "GMP biosynthesis", "GPI-anchor biosynthesis", "Galactose metabolism", "Gastrulation", "Gluconate utilization", "Gluconeogenesis", "Glucose metabolism", "Glutathione biosynthesis", "Glycogen biosynthesis", "Glycogen metabolism", "Glycolysis", "Glyoxylate bypass", "Growth arrest", "Growth regulation", "Hearing", "Heme biosynthesis", "Host-virus interaction", "Hydrogen ion transport", "Hypusine biosynthesis", "Immunity", "Inflammatory response", "Inhibition of host STAT1 by virus", "Inhibition of host STAT2 by virus", "Inhibition of host innate immune response by virus", "Inhibition of host interferon signaling pathway by virus", "Innate immunity", "Inositol biosynthesis", "Ion transport", "Iron storage", "Isoprene biosynthesis", "Keratinization", "Leukotriene biosynthesis", "Lipid biosynthesis", "Lipid degradation", "Lipid metabolism", "Lipid transport", "Meiosis", "Methionine biosynthesis", "Methotrexate resistance", "Mitosis", "Molybdenum cofactor biosynthesis", "Myogenesis", "Necrosis", "Neurogenesis", "Neurotransmitter degradation", "Neurotransmitter transport", "Nonsense-mediated mRNA decay", "Notch signaling pathway", "Nucleotide biosynthesis", "Nucleotide metabolism", "One-carbon metabolism", "Oogenesis", "Pentose shunt", "Peroxisome biogenesis", "Phagocytosis", "Phenylalanine catabolism", "Phospholipid biosynthesis", "Phospholipid metabolism", "Plasminogen activation", "Polyamine biosynthesis", "Porphyrin biosynthesis", "Potassium transport", "Proline biosynthesis", "Proline metabolism", "Prostaglandin biosynthesis", "Prostaglandin metabolism", "Protein biosynthesis", "Protein transport", "Purine biosynthesis", "Purine salvage", "Pyridine nucleotide biosynthesis", "Pyrimidine biosynthesis", "RNA-mediated gene silencing", "Respiratory chain", "Ribosome biogenesis", "Sensory transduction", "Serine biosynthesis", "Sodium transport", "Sodium/potassium transport", "Spermatogenesis", "Spermidine biosynthesis", "Sphingolipid metabolism", "Steroid biosynthesis", "Steroid metabolism", "Sterol biosynthesis", "Sterol metabolism", "Stress response", "Sugar transport", "Symport", "Tetrahydrobiopterin biosynthesis", "Transcription", "Transcription regulation", "Transcription termination", "Translation regulation", "Translocation", "Transport", "Tricarboxylic acid cycle", "Tyrosine catabolism", "Ubiquinone biosynthesis", "Ubl conjugation pathway", "Unfolded protein response", "Urea cycle", "Viral RNA replication", "Viral immunoevasion", "Viral penetration into host nucleus", "Virus entry into host cell", "Vision", "Wnt signaling pathway", "Xylose metabolism", "Zinc transport", "mRNA capping", "mRNA processing", "mRNA splicing", "mRNA transport", "rRNA processing", "tRNA processing"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF3", "ABHD12", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOX1", "ACOX3", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN4", "ACTR3", "ADA", "ADAR", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AGFG1", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AKAP17A", "AKAP8", "AKAP8L", "AKT2", "ALCAM", "ALDH18A1", "ALDH3A2", "ALDH4A1", "ALDOA", "ALDOC", "ALKBH5", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANKFY1", "ANKLE2", "ANLN", "ANO6", "ANP32B", "ANXA1", "ANXA11", "ANXA2", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APC", "APEX1", "API5", "APOO", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARG2", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID4B", "ARIH1", "ARIH2", "ARL2", "ARL3", "ARL6", "ARL6IP1", "ARL8B", "ARMT1", "ASAH1", "ASCC1", "ASCC2", "ASCC3", "ASF1A", "ASH2L", "ASNA1", "ASNS", "ATAD2", "ATG13", "ATG3", "ATG4B", "ATIC", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATP7B", "AUP1", "AURKA", "BABAM2", "BAG6", "BANF1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS2", "BCCIP", "BCL10", "BCL2L13", "BCLAF1", "BEND3", "BICD2", "BIRC6", "BMS1", "BNIP1", "BOP1", "BRAP", "BRAT1", "BRCA1", "BRD1", "BRD2", "BRD3", "BRD4", "BRD7", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf43", "C1QBP", "C2CD5", "CACYBP", "CAD", "CALCOCO1", "CAMK2G", "CAMSAP3", "CAND1", "CANX", "CAPRIN1", "CARM1", "CARS", "CARS2", "CBX3", "CBX5", "CC2D1A", "CCAR1", "CCAR2", "CCDC124", "CCDC22", "CCDC86", "CCDC93", "CCNB1", "CCNK", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC23", "CDC27", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK16", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK5RAP3", "CDK7", "CDK9", "CDKAL1", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPV", "CEP290", "CETN2", "CFL1", "CGGBP1", "CHAF1A", "CHAF1B", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHEK2", "CHID1", "CHKA", "CHMP1A", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHP1", "CHST14", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP5", "CLASP2", "CLCN3", "CLIC1", "CLIC4", "CLINT1", "CLPTM1", "CLPTM1L", "CLTA", "CLTC", "CMPK1", "CMTR1", "CNNM3", "CNNM4", "CNOT1", "CNOT3", "CNOT7", "CNOT9", "COASY", "COG3", "COG7", "COG8", "COMMD1", "COMMD4", "COMMD7", "COMT", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS6", "COPS7A", "COPZ1", "COQ8A", "COX2", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CRNKL1", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK1E", "CSNK2A2", "CSNK2B", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUL7", "CXADR", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DCAF1", "DCAF13", "DCAF7", "DCP1B", "DCPS", "DCTN1", "DCTN3", "DCXR", "DDB1", "DDRGK1", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX46", "DDX47", "DDX5", "DDX51", "DDX54", "DDX56", "DEGS1", "DENR", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DICER1", "DIDO1", "DIS3", "DKC1", "DLAT", "DLG1", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA3", "DNAJB1", "DNAJC13", "DNAJC2", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOCK7", "DOHH", "DPF2", "DPYSL2", "DR1", "DSG2", "DST", "DTYMK", "DUS2", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECD", "ECH1", "ECHS1", "ECI1", "ECSIT", "EDF1", "EDRF1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHHADH", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC4", "EMG1", "EML4", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERO1A", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC4", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAM162A", "FAM208A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXO22", "FBXO7", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP8", "FLII", "FLNA", "FLNB", "FLOT2", "FNBP1", "FOXK1", "FOXK2", "FOXRED1", "FRG1", "FTL", "FTSJ3", "FUBP1", "FUBP3", "FXR1", "G3BP1", "G3BP2", "G6PD", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCC2", "GCFC2", "GCLC", "GCN1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA2", "GGPS1", "GHITM", "GINS1", "GINS2", "GINS3", "GINS4", "GLTP", "GM2A", "GMPS", "GNAI1", "GNAI2", "GNAI3", "GNL2", "GNL3L", "GNPDA1", "GOLGA2", "GOLPH3", "GOLT1B", "GORASP2", "GOSR1", "GOSR2", "GOT1", "GOT2", "GPAT4", "GPI", "GPKOW", "GPR89B", "GRB2", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSS", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2H4", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP3", "GTPBP4", "GUF1", "GYG1", "GYS1", "H2AFX", "HACD2", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAUS1", "HAUS2", "HAUS4", "HAUS5", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HELLS", "HGS", "HIBADH", "HIBCH", "HINT2", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCR", "HMGCS1", "HMGXB4", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HPRT1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IFT88", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBKG", "ILF2", "ILF3", "ILVBL", "IMP3", "IMPDH1", "IMPDH2", "INA", "INCENP", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IST1", "ISYNA1", "ITGAV", "ITGB1", "ITPA", "IVD", "IWS1", "JAGN1", "JUP", "KARS", "KAT7", "KCTD5", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0391", "KIAA1468", "KIF11", "KIF20A", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIFBP", "KIN", "KLC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRR1", "LAMB1", "LAMP1", "LAMP2", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LCMT2", "LDAH", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LPCAT1", "LRPPRC", "LRRC8C", "LRWD1", "LSM14B", "LSM2", "LSM4", "LSM6", "LSS", "LTA4H", "LUC7L3", "LYAR", "LYPLA1", "LYPLA2", "M6PR", "MACF1", "MAD2L1", "MAGT1", "MANF", "MAP1S", "MAP3K7", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARCH5", "MARK2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MECP2", "MED1", "MED14", "MED16", "MED23", "MED24", "MED4", "MESD", "METTL1", "METTL3", "MFAP1", "MFN2", "MFSD10", "MFSD5", "MFSD8", "MGEA5", "MGME1", "MGST2", "MIA3", "MICU1", "MID1", "MIF", "MINDY3", "MKI67", "MLEC", "MMGT1", "MMS19", "MORC2", "MORF4L1", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MRC2", "MRE11", "MRPL41", "MRPL58", "MRPS27", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTFP1", "MTHFD1L", "MTHFD2", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MVD", "MYBBP1A", "MYCBP", "MYCBP2", "MYDGF", "MYH10", "MYH14", "MYH9", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAE1", "NAF1", "NAMPT", "NAP1L1", "NAPA", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCKAP1", "NCOA5", "NCOR1", "NCSTN", "ND5", "NDC1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFB10", "NDUFB11", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS5", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEDD4L", "NEK9", "NELFCD", "NELFE", "NES", "NFRKB", "NFS1", "NHP2", "NIP7", "NIPBL", "NISCH", "NKRF", "NLE1", "NME1", "NME2", "NOA1", "NOC2L", "NOL11", "NOL8", "NOL9", "NONO", "NOP10", "NOP14", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPHP3", "NPLOC4", "NPM1", "NRP1", "NSA2", "NSD1", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NT5C3B", "NUBP2", "NUCKS1", "NUDC", "NUDCD1", "NUDT21", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OCRL", "OGDH", "OGT", "OPA1", "OPA3", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP2", "PAK1IP1", "PAK2", "PAK4", "PANK4", "PAPOLA", "PARK7", "PARN", "PARP1", "PARP2", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCID2", "PCK2", "PCM1", "PCNA", "PCNP", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDK1", "PDK3", "PDS5A", "PDS5B", "PDSS2", "PECR", "PELP1", "PEPD", "PES1", "PEX1", "PEX14", "PEX19", "PFAS", "PFKL", "PFKM", "PFKP", "PGAM1", "PGAM5", "PGD", "PGK1", "PGM1", "PGM2", "PGM3", "PGP", "PHAX", "PHB", "PHB2", "PHF10", "PHF5A", "PHF6", "PHGDH", "PICALM", "PIGG", "PIGK", "PIGS", "PIGT", "PIH1D1", "PIK3C2A", "PIK3R2", "PIR", "PISD", "PITHD1", "PITPNB", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLIN3", "PLK1", "PLRG1", "PMVK", "PNN", "PNP", "PNPLA6", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR2L", "POLR3A", "POLR3C", "POLR3E", "POLRMT", "POP1", "PPAT", "PPHLN1", "PPID", "PPIF", "PPIH", "PPIL1", "PPM1F", "PPOX", "PPP1CA", "PPP1CB", "PPP1R9B", "PPP2R1A", "PPP5C", "PPP6C", "PPT1", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKAA2", "PRKAG1", "PRKCD", "PRKDC", "PRKRA", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPSAP1", "PRPSAP2", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC3", "PSMD10", "PSMD14", "PSME3", "PSPC1", "PSPH", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTK7", "PTPRF", "PTRH2", "PUF60", "PUM1", "PURA", "PUS1", "PUS7", "PWP1", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB3B", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RABGEF1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP2", "RANBP3", "RAPGEF2", "RARS", "RBBP5", "RBBP6", "RBFA", "RBM10", "RBM14", "RBM15", "RBM17", "RBM22", "RBM25", "RBM28", "RBM3", "RBM39", "RBM4", "RBM45", "RBM5", "RBM7", "RBM8A", "RBMX", "RBPJ", "RCC1", "RCC2", "RCL1", "REEP4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RIF1", "RINT1", "RIOK2", "RIPK1", "RMDN3", "RMND1", "RNASET2", "RNF2", "RNF20", "RNF219", "RNF40", "RNMT", "RNPS1", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPA3", "RPF1", "RPF2", "RPL10", "RPL13A", "RPP30", "RPRD1B", "RPS3", "RPS3A", "RPS6KA1", "RPS6KA3", "RPSA", "RPUSD3", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP1B", "RRP36", "RRP8", "RRP9", "RRS1", "RSF1", "RTCB", "RTF1", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A13", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SC5D", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCAP", "SCARB1", "SCARB2", "SCD", "SCFD1", "SCML2", "SCP2", "SCRIB", "SCRN1", "SDAD1", "SDF4", "SDHA", "SDHB", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERPINH1", "SET", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHMT1", "SHMT2", "SIGMAR1", "SIN3A", "SIN3B", "SIRT1", "SIRT2", "SKA3", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC2A8", "SLC30A5", "SLC30A9", "SLC35B2", "SLC35F2", "SLC38A1", "SLC39A14", "SLC3A2", "SLC44A1", "SLC4A7", "SLC7A1", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMG5", "SMG8", "SMN1*", "SMNDC1", "SMS", "SMU1", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNIP1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX2", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SON", "SPATA5", "SPC24", "SPC25", "SPDL1", "SPECC1L", "SPEN", "SPTLC1", "SPTLC2", "SQSTM1", "SRCAP", "SREK1", "SRFBP1", "SRM", "SRPK1", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSBP1", "SSRP1", "ST3GAL4", "STAG1", "STAG2", "STAM", "STAMBP", "STAT1", "STAT3", "STAU1", "STAU2", "STK26", "STK4", "STMN1", "STRAP", "STRBP", "STUB1", "STX10", "STX12", "STX18", "STX4", "STX5", "STX6", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE1", "SYNGR2", "TACC3", "TAF6L", "TALDO1", "TARDBP", "TARS", "TARS2", "TARSL2", "TAX1BP1", "TBCB", "TCAF1", "TCEA1", "TCERG1", "TDP2", "TECR", "TEFM", "TERF2IP", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THRAP3", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM13", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TK1", "TLN1", "TMBIM6", "TMCO1", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM14C", "TMEM214", "TMF1", "TMLHE", "TMX1", "TMX4", "TNPO1", "TNPO3", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM6", "TOMM70", "TOP1", "TOP2A", "TP53", "TP53BP1", "TPI1", "TPR", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAPPC2L", "TRAPPC3", "TRAPPC5", "TRAPPC8", "TRIM13", "TRIM21", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP10", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMT11", "TRMT1L", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TSC2", "TSFM", "TSG101", "TSNAX", "TSR1", "TSR3", "TTC19", "TTC26", "TTC4", "TTF2", "TTLL12", "TUBB2B", "TUFM", "TWF2", "TWNK", "TXLNA", "TXLNG", "TXNL1", "TXNL4A", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAC1", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBL5", "UBP1", "UBQLN2", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN1", "UBXN4", "UCHL5", "UFC1", "UFD1", "UFL1", "UFSP2", "UGDH", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "UROD", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP28", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "VAMP7", "VAPA", "VAPB", "VARS1", "VARS2", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VMP1", "VPS13A", "VPS16", "VPS18", "VPS25", "VPS26A", "VPS26B", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "WAPL", "WARS", "WARS2", "WBP11", "WDR12", "WDR36", "WDR4", "WDR41", "WDR43", "WDR5", "WDR6", "WDR61", "WDR75", "WIPI2", "WRAP53", "WTAP", "XAB2", "XPA", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YIF1A", "YIF1B", "YIPF4", "YKT6", "YLPM1", "YTHDC1", "YTHDF2", "YWHAB", "YWHAE", "ZC3H11A", "ZC3H7B", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZMYM2", "ZNF207", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF638", "ZPR1", "ZW10", "ZWILCH", "ZYX", "ZZZ3"], "leading_proteins": ["ACOX1", "ACP6", "ADA", "AGPS", "AHSA1", "AIFM1", "AKT2", "ALDH3A2", "ANO6", "APOO", "ARL6IP1", "ASAH1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5L", "ATP6", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V1E1", "ATP7A", "ATP7B", "BAG6", "BCAP31", "BCL2L13", "BICD2", "BNIP1", "CD47", "CDS2", "CETN2", "CHKA", "CHMP3", "CIRBP", "CLCN3", "CLPTM1L", "CNNM3", "CNNM4", "COX2", "CPT1A", "CPT2", "CYB5B", "CYB5R3", "CYP51A1", "DAGLB", "DERL1", "DHCR24", "DIABLO", "DNAJC3", "DOCK1", "ECH1", "ELMO2", "EMC4", "EPB41L3", "EPHA7", "ERGIC3", "ERLIN1", "ERLIN2", "ERO1A", "FAM162A", "FDFT1", "FDPS", "FECH", "FOXRED1", "GBA", "GHITM", "GM2A", "GOSR1", "GPR89B", "HACD3", "HMGCR", "HMOX1", "HSD17B12", "HTRA2", "ILVBL", "KDELR1", "KDSR", "LAMP2", "LASP1", "LBR", "LDAH", "LETM1", "LGALS3BP", "LIPA", "LPCAT1", "LRRC8C", "LTA4H", "MBOAT7", "MCL1", "MCU", "MFN2", "MFSD10", "MICU1", "MSMO1", "MTCH1", "MTFP1", "NDC1", "NDUFA11", "NDUFA13", "NDUFB10", "NDUFB11", "NDUFB4", "NDUFB8", "NDUFB9", "NPC1", "NSDHL", "NUP35", "NUP37", "NUP54", "NUP93", "OPA1", "OPA3", "PCBD1", "PDCD5", "PDCL3", "PDE6D", "PECR", "PEX14", "PIGG", "PIGK", "PIGS", "PISD", "PLA2G15", "PLBD2", "PLD6", "PPT1", "PSME3", "PTDSS2", "PTGES2", "PTRH2", "PUF60", "RAB1B", "RAB24", "RACGAP1", "RBM3", "RBM5", "RMDN3", "RTN3", "SC5D", "SCAP", "SDHB", "SEC62", "SEL1L", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SH3GLB1", "SIGMAR1", "SIRT2", "SLC12A2", "SLC19A1", "SLC1A5", "SLC25A22", "SLC25A4", "SLC25A6", "SLC2A8", "SLC30A5", "SLC39A14", "SLC3A2", "SLC4A7", "SLC7A1", "SNAP29", "SPTLC1", "SQSTM1", "ST3GAL4", "STX18", "TEX264", "TIAL1", 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0000000000000000000000000000000000000000..7fe6f6bed223712f2c1c9fb1f43bb4f3461cf84d --- /dev/null +++ b/protein_atlas_disease_involvement/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:15919bc9bfc53857548045a2d1de57544f19883f84551020ffc79c81125f57fd +size 75394 diff --git a/protein_atlas_disease_involvement/df_merge.tsv b/protein_atlas_disease_involvement/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..ce01a0d87cdd5806644e2a32aca8720b9fe29d79 --- /dev/null +++ b/protein_atlas_disease_involvement/df_merge.tsv @@ -0,0 +1,5 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Primary mitochondrial disease 28 97 3.095487442246512 0.0019648969303462 27.53640776699029 92.44660194174756 0.9978626953080288 0.3665723479658412 11.863754653333944 10.66022291187525 1.7959996823414457 0.3879563837717744 1.0276791168304886e-11 0.043639766392674 3.090226013595508e-05 5.031238831610004e-10 7.835083357352949e-11 +Mucopolysaccharidosis 3 5 2.119031233893561 0.0340878274256848 2.254854368932039 4.752427184466019 0.4843930061917075 0.2034155563537636 0.9831595235232706 0.7286567852681505 1.626107445717624 0.2463507210616131 0.0006182072975801 1.0 1.0 0.0276231155809849 0.0013781701696679 +Cataract 8 27 2.091275926497945 0.036503336524595 7.509708737864078 26.679611650485437 0.6066406061606927 0.4718259290301406 3.570701015264242 3.2395121058789256 1.0572468917106954 0.3422408621391183 0.0066058610620021 1.0 0.4242240140575919 0.0483010618227088 0.005918859062877 +Congenital disorder of glycosylation 9 17 2.0101054222204 0.0444200323159775 5.618932038834951 18.325242718446603 0.4013656328493284 0.4500757016048167 2.8520016519219875 3.440343696044481 1.1296344785223882 0.3186521023843959 0.0078294251515635 1.0 1.0 0.2961580697833918 0.020723717832043 diff --git a/protein_atlas_disease_involvement/metrics.json b/protein_atlas_disease_involvement/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..e9ff0594bb0a6d18646d751a9bf2e9de4b58cc23 --- /dev/null +++ b/protein_atlas_disease_involvement/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3120, + "annotations_size": 115, + "title": "Average number of proteins per term", + "value": 22.208695652173912 +} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/paths.json b/protein_atlas_disease_involvement/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..cf743bfc5839f15ee2e1ebf6c4a51adb5ca753fc --- /dev/null +++ b/protein_atlas_disease_involvement/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_disease_involvement/fragment/C390/C390_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/result.tsv b/protein_atlas_disease_involvement/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..dfdfeb755b0b39f6e334c33f7c3991a0bb128b4b --- /dev/null +++ b/protein_atlas_disease_involvement/result.tsv @@ -0,0 +1,35 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Primary mitochondrial disease 0.5414193365082781 3.0954874422465117 0.0019648969303462 0.2024298097688399 0.2259631469898238 97 Q5XKP0,Q9P0J0,Q9Y2R0,O75880,O14949,Q7KZN9,P13073,O95169,P14927,Q70HW3,Q9BQT8,Q86Y39,Q53H12,Q96CU9,Q96IX5,P00846,P20674,P22695,O60313,Q9Y6M9,O95831,Q9UBX3,O43819,P00403,Q8IUX1,Q6P4A7,Q9Y276,Q9NPL8 28 +Neuronal ceroid lipofuscinosis 0.9503186159119557 2.3089995913804353 0.0209436039174188 0.9123228284622804 0.3229141307944945 4 O14773,P50897 2 +Mucopolysaccharidosis 0.8278167642158427 2.1190312338935615 0.0340878274256848 0.9814720017076324 0.3229141307944945 5 P16278,P15586,P54802 3 +Cataract 0.5175443487752316 2.091275926497945 0.036503336524595 0.9861076814835844 0.3229141307944945 27 P08670,Q9UG56,Q53H12,Q15800,O76024,O00116,Q9H6K4,Q8NC56 8 +Congenital disorder of glycosylation 0.5742158617453527 2.0101054222204 0.0444200323159775 0.9946209047337832 0.3648788368812443 17 Q9H0U3,P83436,Q9BT22,Q9H6U8,P46977,P51571,O75787,Q9BV10,Q15904 9 +Gangliosidosis 0.8314988411618705 1.8204274362252597 0.0686939374191653 0.9997209837717884 0.3949901401602004 4 P17900,P16278 2 +Ehlers-Danlos syndrome 0.8136106058989044 1.74498896760935 0.0809867893785485 0.9999394656690028 0.4386659988559306 4 Q8NCH0,Q96L58 2 +Congenital muscular dystrophy 0.6597103909883919 1.584096498095282 0.1131717611863649 0.9999989964383128 0.527284779686979 7 O43505,P02545,Q14118 3 +Ichthyosis 0.6584247406848669 1.577732285013255 0.1146271260189084 0.9999991691657828 0.527284779686979 7 O95721,P51648 2 +Leigh syndrome 0.569306464578651 1.5313259600205509 0.1256888526990012 0.999999804299564 0.5559314638609669 11 Q7KZN9,P00846 2 +Hereditary spastic paraplegia 0.5359814730805986 1.4649541656382563 0.1429334231948904 0.9999999801995844 0.57785024848821 13 O94905,O75298,Q15041 3 +Limb-girdle muscular dystrophy 0.6012720699226877 1.291658806444279 0.196475329092697 0.9999999999881174 0.728860091795489 7 O14979,P02545,Q5JTV8,Q14118 4 +Dystroglycanopathy 0.6402513554088135 1.2687675985239486 0.2045239646292644 0.9999999999962664 0.7350079978864192 5 O43505,Q14118 2 +Dystonia 0.5434252209348823 1.1359209157576493 0.2559896638370276 0.9999999999999984 0.8246514173860909 8 P04350,P51572,Q15043 3 +Cardiomyopathy 0.4011563698230589 1.0697042469510378 0.2847524541002588 1.0 0.8261967221754248 25 P12235,Q53H12,O60313,P02545,Q9NX14,O43819,Q9BTV4,P50402,P00846 9 +Spinocerebellar ataxia 0.4901240828769728 1.061698515681216 0.288372573420282 1.0 0.8261967221754248 11 O14773 1 +Emery-Dreifuss muscular dystrophy 0.5649121512329123 1.0173815554460588 0.3089719528907231 1.0 0.8261967221754248 6 Q9BTV4,P50402 2 +Amyotrophic lateral sclerosis 0.4324887173111772 0.9757818277485464 0.3291725919329651 1.0 0.8261967221754248 16 Q99720,Q9UHD9,Q9NRR5,P35637,Q9UQN3 5 +Parkinsonism 0.4332326881853149 0.9345905519193068 0.3499993499706262 1.0 0.8261967221754248 15 O75569,Q709C8,Q96A57,Q15043,P04062,O75787 6 +Hirschsprung disease 0.787042976266865 0.922822070895705 0.3560999370278737 1.0 0.8261967221754248 2 P42892 1 +Zellweger syndrome 0.7613535781574405 0.907583445238482 0.3640983440369427 1.0 0.8261967221754248 3 O75381 1 +Peroxisome biogenesis disorder 0.7613535781574405 0.907583445238482 0.3640983440369427 1.0 0.8261967221754248 3 O75381 1 +Progressive external ophthalmoplegia 0.4616372391653328 0.461381193449752 0.6445251418512947 1.0 0.9392010921015138 5 Q96RR1,P51530,P12235,P54098 4 +Neurodegeneration 0.3519605268532209 0.4128108951627137 0.6797451683758418 1.0 0.941815594737612 143 O14773,Q99720,Q8TB36,Q9NW15,P61026,Q03252,Q04656,P04062,Q15041,O15269,P35637,O75298,Q14108,Q8NI60,Q709C8,Q13510,Q9UHD9,P02792,O75477,P50897,Q13501,Q96D71,P02545,Q10713,P07196,Q16637,Q9UQN3,O75503,O43464,Q13217,Q8IXJ6,Q9Y4W6,P05023,Q9HD42,Q15043,O95831,O60313,O94905,P07686,Q96A57,Q9NRR5,Q8IV08,O95140,Q8TD16,O75787,P54802,Q9Y320,P06865 48 +Deafness 0.295087562375725 0.3770895601128264 0.7061070493381791 1.0 0.9666941746891738 51 Q15067,Q9NR28,Q9UG56,Q9NWM8,Q9Y276,O95831,O60313,P51572,O76024,Q16740,P68371 11 +Neuropathy 0.2858668628097759 0.2684277204740069 0.7883701043410598 1.0 1.0 50 Q13217,P05023,O95831,O95721,Q9HC21,P54802,O15269,P07196,P00846,Q15067 10 +Parkinson disease 0.3558026873017149 0.2458324517229759 0.8058119349258384 1.0 1.0 10 Q96A57 1 +FDA approved drug targets 0.3115914032028479 0.1561662280353754 0.8759019962101422 1.0 1.0 121 P28074,Q99720,P49721,Q8N0U8,P20020,O95749,Q02127,P23786,P50416,P16615,P98194,Q14534,P04035,P00374,P05023,P07437,P00813,P21964,P20645,Q13423,P10253,Q16850,P38435,P68371 24 +Diabetes mellitus 0.3192150072876392 0.0821579283863757 0.9345211285793108 1.0 1.0 10 Q13217,P31751,O76024,Q5VV42 4 +Epilepsy 0.2531966834342304 0.0265239556317892 0.978839426487626 1.0 1.0 70 O14773,P16615,O75503,Q14108,Q13510 5 +Hypogonadotropic hypogonadism 0.3813341885824214 0.0235339051402541 0.9812243935775112 1.0 1.0 2 Q8IY17 1 +Aicardi-Goutieres syndrome 0.3875521334616632 0.0055758927614753 0.995551104306063 1.0 1.0 3 O75792,Q9Y3Z3 2 +Congenital myasthenic syndrome 0.3809292216004127 0.0024596134296248 0.9980375143977 1.0 1.0 3 Q4J6C6 1 +Lissencephaly 0.2917904307164051 0.0018646476166165 0.998512227317506 1.0 1.0 12 O43505,Q9Y320,Q14118 3 diff --git a/protein_atlas_disease_involvement/selections.json b/protein_atlas_disease_involvement/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..62476d504a95033915e97fc62f903d39146c88db --- /dev/null +++ b/protein_atlas_disease_involvement/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Aicardi-Goutieres syndrome", "Albinism", "Allergen", "Alport syndrome", "Alzheimer disease", "Amelogenesis imperfecta", "Amyloidosis", "Amyotrophic lateral sclerosis", "Atrial fibrillation", "Autism", "Autism spectrum disorder", "Bardet-Biedl syndrome", "Bartter syndrome", "Brugada syndrome", "Cancer-related genes", "Cardiomyopathy", "Cataract", "Charcot-Marie-Tooth disease", "Ciliopathy", "Cockayne syndrome", "Cone-rod dystrophy", "Congenital adrenal hyperplasia", "Congenital disorder of glycosylation", "Congenital dyserythropoietic anemia", "Congenital hypothyroidism", "Congenital muscular dystrophy", "Congenital myasthenic syndrome", "Craniosynostosis", "Cushing syndrome", "Deafness", "Diabetes insipidus", "Diabetes mellitus", "Diamond-Blackfan anemia", "Disease variant", "Dwarfism", "Dyskeratosis congenita", "Dystonia", "Dystroglycanopathy", "Ectodermal dysplasia", "Ehlers-Danlos syndrome", "Elliptocytosis", "Emery-Dreifuss muscular dystrophy", "Epidermolysis bullosa", "Epilepsy", "FDA approved drug targets", "Fanconi anemia", "Gangliosidosis", "Gaucher disease", "Glaucoma", "Glutaricaciduria", "Glycogen storage disease", "Gout", "Hereditary hemolytic anemia", "Hereditary nonpolyposis colorectal cancer", "Hereditary spastic paraplegia", "Hermansky-Pudlak syndrome", "Hirschsprung disease", "Holoprosencephaly", "Hypogonadotropic hypogonadism", "Hypotrichosis", "Ichthyosis", "Intrahepatic cholestasis", "Joubert syndrome", "Kallmann syndrome", "Kartagener syndrome", "Leber congenital amaurosis", "Leber hereditary optic neuropathy", "Leigh syndrome", "Leukodystrophy", "Li-Fraumeni syndrome", "Limb-girdle muscular dystrophy", "Lissencephaly", "Long QT syndrome", "MELAS syndrome", "Maple syrup urine disease", "Meckel syndrome", "Mental retardation", "Microphthalmia", "Mucopolysaccharidosis", "Myofibrillar myopathy", "Nemaline myopathy", "Nephronophthisis", "Neurodegeneration", "Neuronal ceroid lipofuscinosis", "Neuropathy", "Niemann-Pick disease", "Non-syndromic deafness", "Obesity", "Oncogene", "Osteogenesis imperfecta", "Osteopetrosis", "Palmoplantar keratoderma", "Parkinson disease", "Parkinsonism", "Peroxisome biogenesis disorder", "Phenylketonuria", "Premature ovarian failure", "Primary ciliary dyskinesia", "Primary hypomagnesemia", "Primary microcephaly", "Primary mitochondrial disease", "Progressive external ophthalmoplegia", "Proto-oncogene", "Pyropoikilocytosis", "Retinitis pigmentosa", "Rhizomelic chondrodysplasia punctata", "SCID", "Schizophrenia", "Senior-Loken syndrome", "Spinocerebellar ataxia", "Systemic lupus erythematosus", "Tumor suppressor", "Williams-Beuren syndrome", "Xeroderma pigmentosum", "Zellweger syndrome"], "available_proteins": ["AAAS", "AARS", "AARS2", "ABCB1", "ABCB7", "ABHD12", "ACAA1", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACLY", "ACO1", "ACO2", "ACOX1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ADA", "ADAR", "ADD3", "ADK", "ADNP", "ADPRHL2", "ADSL", "AFDN", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP12", "AKAP9", "AKR1B1", "AKT2", "ALCAM", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALG9", "ANAPC1", "ANK3", "ANKLE2", "ANLN", "ANO10", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA7", "AP1B1", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "APC", "APEX1", "APRT", "ARCN1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARIH1", "ARL2", "ARL3", "ARL6", "ARL6IP1", "ARPC1B", "ASAH1", "ASCC1", "ASNS", "ASPH", "ATAD1", "ATAD3A", "ATG13", "ATIC", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP7A", "ATP7B", "ATXN10", "ATXN2", "AURKA", "B3GALT6", "B4GAT1", "BANF1", "BAZ1B", "BCAP31", "BCKDK", "BCL10", "BCLAF1", "BCS1L", "BICD2", "BIRC6", "BLMH", "BLVRB", "BMS1", "BRAT1", "BRCA1", "BRD3", "BRD4", "BRD7", "BUB1B", "BUD23", "C19orf70", "C1QBP", "CAD", "CALR", "CAMK2G", "CANX", "CAPN1", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CC2D1A", "CCAR1", "CCAR2", "CCDC22", "CCDC47", "CCDC6", "CCDC8", "CCNB1", "CCNK", "CCT5", "CDC27", "CDC37", "CDC42", "CDC73", "CDH2", "CDK1", "CDK12", "CDK2", "CDK4", "CDK5", "CDK5RAP2", "CDK7", "CDKAL1", "CEP290", "CFL2", "CHAMP1", "CHD1", "CHD4", "CHD8", "CHEK2", "CHMP1A", "CHMP2B", "CHMP4B", "CHP1", "CHST14", "CISD2", "CIZ1", "CKB", "CKMT1A*", "CLIC1", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNNM4", "CNOT1", "CNOT3", "COA3", "COA7", "COASY", "COG7", "COG8", "COLGALT1", "COMT", "COPA", "COPB2", "COQ8A", "COX14", "COX15", "COX2", "COX4I1", "COX5A", "CPOX", "CPSF1", "CPT1A", "CPT2", "CRK", "CRTAP", "CSDE1", "CSE1L", "CSNK1E", "CSNK2A2", "CSNK2B", "CSTB", "CTBP1", "CTCF", "CTNNB1", "CTNNBL1", "CTNND1", "CTSA", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUL7", "CWF19L1", "CXorf56", "CYB5R3", "CYC1", "CYFIP2", "CYP51A1", "DAD1", "DAG1", "DARS", "DARS2", "DBN1", "DBT", "DCPS", "DCTN1", "DDOST", "DDRGK1", "DDX10", "DDX3X", "DDX41", "DDX5", "DDX6", "DEGS1", "DEK", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHTKD1", "DHX16", "DHX30", "DHX37", "DHX38", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIS3", "DKC1", "DLD", "DLST", "DNA2", "DNAAF5", "DNAJB1", "DNAJB11", "DNAJC13", "DNAJC2", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPF2", "DPM1", "DSG2", "DSP", "DST", "DYM", "DYNC1H1", "DYNC2H1", "DYNLL1", "EARS2", "ECE1", "ECHS1", "EDC3", "EED", "EEF1A2", "EEF2", "EFL1", "EFTUD2", "EHHADH", "EHMT1", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S2", "EIF3E", "EIF3F", "EIF3H", "EIF4A2", "EIF4A3", "EIF4E", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELP1", "ELP2", "ELP3", "EMC1", "EMD", "EMG1", "EML4", "ENO1", "ENO2", "EPB41", "EPB41L3", "EPHA7", "EPHX1", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERC1", "ERCC3", "ERGIC1", "ERLIN1", "ERLIN2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXOC6B", "EXOSC2", "EXOSC3", "EXOSC8", "EXOSC9", "EZR", "FADS2", "FAF1", "FAH", "FAM120A", "FAM3C", "FANCD2", "FANCI", "FAR1", "FARSB", "FASN", "FASTKD2", "FBXO7", "FDPS", "FDXR", "FECH", "FEN1", "FGFR1OP", "FH", "FHL1", "FIP1L1", "FKBP10", "FKBP14", "FKBP5", "FKBP8", "FKRP", "FLAD1", "FLNA", "FLNB", "FLNC", "FNTA", "FNTB", "FOXRED1", "FSCN1", "FTL", "FTO", "FUBP1", "FUCA1", "FUS", "G6PD", "GAA", "GALK1", "GALNT2", "GANAB", "GAPDH", "GARS", "GART", "GATAD2B", "GATB", "GATC", "GBA", "GCDH", "GCLC", "GDAP1", "GDI1", "GEMIN4", "GFM1", "GFPT1", "GGCX", "GGPS1", "GIGYF2", "GINS1", "GIPC1", "GLA", "GLB1", "GLDC", "GLMN", "GLO1", "GLRX5", "GLS", "GLUD1", "GM2A", "GMPPA", "GMPS", "GNA13", "GNAI1", "GNAI3", "GNAO1", "GNPAT", "GNS", "GOLGA5", "GOSR2", "GOT1", "GOT2", "GPD1L", "GPI", "GPRASP2", "GPT2", "GRB2", "GSK3A", "GSK3B", "GSR", "GSS", "GSTM3", "GSTZ1", "GTF2I", "GTPBP3", "GUF1", "GUSB", "GYG1", "GYS1", "H4C1*", "HADH", "HADHA", "HADHB", "HARS2", "HAX1", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HELLS", "HEXA", "HEXB", "HIBCH", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLCS", "HMBS", "HMGA1", "HMGB3", "HMGCL", "HMGCR", "HMGXB4", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HPRT1", "HPS6", "HSD17B10", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTRA2", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFT27", "IGF2R", "IKBKG", "ILF3", "IMPAD1", "IMPDH1", "IMPDH2", "INF2", "INTS1", "INTS12", "INTS8", "IPO7", "IRF2BPL", "IRS4", "ITGAV", "ITGB1", "ITPA", "IVD", "JAGN1", "JUP", "KARS", "KDM1A", "KDM3B", "KDM5A", "KDSR", "KIF11", "KIF14", "KIF1A", "KIF22", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KTN1", "L2HGDH", "LAMB1", "LAMP2", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LGALS3", "LGALS3BP", "LIPA", "LMNA", "LMNB1", "LMNB2", "LNPK", "LONP1", "LRBA", "LRPPRC", "LSS", "LTA4H", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAP1B", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4", "MAPK1", "MAPK14", "MAPK3", "MARS", "MATR3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM5", "MCM7", "MCTS1", "MDC1", "MDH1", "MDH2", "MECP2", "MED1", "MED23", "MESD", "MFN2", "MFSD8", "MGME1", "MICU1", "MID1", "MIF", "MINPP1", "MIPEP", "MKI67", "MMAB", "MOGS", "MORC2", "MPI", "MRE11", "MRPL12", "MRPL3", "MRPL44", "MRPS2", "MRPS22", "MRPS23", "MRPS28", "MRPS34", "MRPS7", "MSH2", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTHFS", "MTOR", "MTPAP", "MTR", "MUT", "MVD", "MYH10", "MYH14", "MYH9", "MYO6", "NAA10", "NAA15", "NAGLU", "NAMPT", "NANS", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG2", "NCAPH", "NCKIPSD", "NCOR1", "NCSTN", "ND5", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA9", "NDUFAF3", "NDUFAF4", "NDUFB11", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP1", "NEDD4L", "NEFL", "NEK9", "NF1", "NHLRC2", "NHP2", "NIPBL", "NISCH", "NME1", "NME2", "NNT", "NONO", "NOP10", "NOP56", "NPC1", "NPC2", "NPHP3", "NPM1", "NRP1", "NSD1", "NSD2", "NSDHL", "NSMCE2", "NSMCE3", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NUCB2", "NUDT1", "NUMA1", "NUP107", "NUP133", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP37", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXN", "OAT", "OCLN", "OCRL", "OGDH", "OGT", "OMA1", "OPA1", "OPA3", "OSGEP", "OTULIN", "OXCT1", "P3H1", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PAFAH1B2", "PARK7", "PARN", "PARP1", "PARP2", "PBRM1", "PC", "PCBD1", "PCBP1", "PCCA", "PCCB", "PCM1", "PCNA", "PDAP1", "PDE6D", "PDHA1", "PDHB", "PDK1", "PDK3", "PDSS2", "PDXK", "PEPD", "PEX1", "PEX14", "PEX19", "PFKM", "PFN1", "PGK1", "PGM1", "PGM3", "PHB", "PHF6", "PHGDH", "PHIP", "PI4KA", "PICALM", "PIGG", "PIGK", "PIGS", "PIGT", "PIK3C2A", "PIK3R2", "PINX1", "PISD", "PKM", "PLAA", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PMPCA", "PMPCB", "PMVK", "PNN", "PNP", "PNPLA6", "PNPT1", "POGZ", "POLA1", "POLD1", "POLE", "POLE2", "POLE4", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR3A", "POP1", "POR", "PPA2", "PPIB", "PPIF", "PPOX", "PPP1CB", "PPP1R12A", "PPP2R1A", "PPP2R5D", "PPP5C", "PPP6C", "PPT1", "PQBP1", "PRC1", "PRCC", "PRDX2", "PRDX4", "PRDX5", "PREPL", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRPF3", "PRPF31", "PRPF4", "PRPF6", "PRPF8", "PRPS1", "PSAT1", "PSIP1", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMD12", "PSMD4", "PSPH", "PTDSS1", "PTPN11", "PTRH2", "PUF60", "PUM1", "PURA", "PUS1", "PUS7", "PYCR1", "PYCR2", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "RAB10", "RAB11B", "RAB18", "RAB23", "RAB3GAP2", "RAB7A", "RAB8A", "RABEP1", "RABL3", "RAC1", "RAD21", "RAD23A", "RAD23B", "RANBP2", "RANBP3", "RAP1GDS1", "RAPGEF2", "RARS", "RASA1", "RBM10", "RBM12", "RBM15", "RBM28", "RBM6", "RBM7", "RBMX", "RBPJ", "RDH11", "RDX", "REPS1", "RFC1", "RFC2", "RHOA", "RINT1", "RIPK1", "RMND1", "RNASEH2A", "RNASET2", "ROCK1", "ROCK2", "RPA2", "RPL10", "RPL11", "RPL13", "RPL15", "RPL18", "RPL21", "RPL22", "RPL26", "RPL27", "RPL3", "RPL35", "RPL35A", "RPL5", "RPN1", "RPS10", "RPS15", "RPS15A", "RPS17", "RPS19", "RPS2", "RPS23", "RPS24", "RPS27", "RPS28", "RPS3", "RPS6KA1", "RPS6KA3", "RPS7", "RPSA", "RRAS2", "RRM1", "RRM2", "RTN2", "SAMHD1", "SARS", "SART1", "SBDS", "SC5D", "SCARB2", "SCO1", "SCO2", "SCRIB", "SCYL2", "SDHA", "SDHB", "SEC23A", "SEC23B", "SEC24D", "SEC31A", "SEC61A1", "SEC63", "SEPT2", "SEPT9", "SERPINB6", "SERPINH1", "SET", "SETDB1", "SF3B1", "SFPQ", "SFXN4", "SGPL1", "SH3GL1", "SHOC2", "SIGMAR1", "SIN3A", "SIRT2", "SKIV2L", "SKP2", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC2A1", "SLC30A9", "SLC38A1", "SLC39A14", "SLC3A2", "SLC44A1", "SLC9A3R1", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC3", "SMCHD1", "SMN1*", "SMPD4", "SMS", "SNAP29", "SND1", "SNIP1", "SNRNP200", "SNRPE", "SNX3", "SOAT1", "SOD2", "SON", "SORD", "SPART", "SPATA5", "SPECC1L", "SPEN", "SPR", "SPTAN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRP54", "SRP72", "SRSF3", "SSB", "SSR4", "STAG1", "STAG2", "STAMBP", "STAT1", "STAT3", "STMN1", "STRAP", "STRN", "STT3A", "STT3B", "STUB1", "STX5", "SUCLA2", "SUCLG1", "SUZ12", "SYNE1", "SYNE2", "TAF15", "TALDO1", "TARDBP", "TARS", "TARS2", "TBC1D4", "TBCD", "TBCE", "TBL2", "TCEA1", "TCOF1", "TDP2", "TECR", "TELO2", "TFAM", "TFG", "TFRC", "THOC2", "THOC6", "TIA1", "TIMM50", "TIMMDC1", "TJP2", "TK1", "TKFC", "TKT", "TLN2", "TMCO1", "TMEM126B", "TMEM230", "TMEM43", "TMEM70", "TMF1", "TMLHE", "TMTC3", "TMX2", "TNPO3", "TOE1", "TOM1", "TOP1", "TOP2A", "TOP2B", "TOR1A", "TOR1AIP1", "TP53", "TP53BP1", "TPD52", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPR", "TPX2", "TRAPPC2L", "TRIM25", "TRIM33", "TRIO", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMU", "TRRAP", "TSC2", "TSFM", "TSG101", "TTC19", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBG1", "TUBGCP2", "TUFM", "TWF1", "TWNK", "TXLNA", "TXNL4A", "TXNRD1", "TYMS", "U2AF1", "UBA1", "UBA5", "UBE2N", "UBE3A", "UBQLN2", "UBQLN4", "UBR5", "UBTF", "UFC1", "UFSP2", "UGDH", "UGP2", "UMPS", "UNG", "UPF3B", "UQCRB", "UQCRC2", "UQCRFS1", "UQCRQ", "UROD", "USMG5", "USP9X", "UTP4", "VANGL1", "VAPB", "VARS1", "VARS2", "VCL", "VCP", "VIM", "VKORC1L1", "VPS13A", "VPS13C", "VPS16", "VPS33A", "VPS33B", "VPS35", "VPS4A", "VPS51", "VPS53", "VRK1", "WARS", "WARS2", "WBP2", "WDR1", "WDR26", "WDR36", "WDR4", "WDR5", "WDR73", "WFS1", "WIPI2", "WRAP53", "XPA", "XPNPEP3", "XPO1", "XRCC1", "XRCC5", "XRCC6", "YARS", "YARS2", "YBX1", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAZ", "ZC3H14", "ZCCHC8", "ZMPSTE24", "ZMYM2"], "leading_proteins": ["ACOX1", "ADA", 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+++ b/protein_atlas_molecular_function/df_merge.tsv @@ -0,0 +1,7 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Receptor 26 38 3.746831503184133 0.0001790822903517 13.475728155339803 38.71116504854369 1.6655960679271569 0.1791616261110447 5.431559450288914 6.105192092581698 1.9169648296245776 0.2753083483896962 0.037233331587491 0.1129146346736405 0.0331776056462107 0.0180949870905955 0.1575835672195456 +Translocase 11 24 2.523911239988142 0.0116057227644408 8.031553398058252 23.23543689320388 0.8266305625937611 0.3429767730570308 3.903132239147793 3.2553774114037415 1.2917497354360188 0.3272657999875639 0.0001003682249153 1.0 0.4407605172427877 0.0031264397563519 2.4886949241689784e-05 +Host cell receptor for virus entry 6 16 2.4330586406700534 0.0149718759165773 4.509708737864078 15.157766990291265 0.7214109752050332 0.2527966464979699 2.499010078306418 1.9009100692398744 1.5211756979359785 0.2791170769282048 0.0011146167435126 0.1801156574188796 0.3339976348230559 0.0180565405233996 0.0037452233271246 +Carboxypeptidase 3 6 2.42077880217602 0.0154872980184923 3.1359223300970873 6.150485436893204 0.9957728306848488 0.1212034427500092 1.2071674596015187 0.4479454254223922 1.8250051834990677 0.2074401112551974 0.0022568934045067 0.0683810764565047 1.0100053103379697e-05 0.000366006536683 0.0005289198821125 +Glycosidase 9 18 2.363291386880207 0.0181134213848686 7.798543689320389 18.135922330097088 0.5112745472223946 0.1951515073440806 2.9064203812520417 1.9684331341643595 1.9501681029822375 0.2619382904734375 3.4636995242041976e-05 1.0 1.0 0.0195417527514502 2.990302515741305e-05 +Glycosyltransferase 9 31 2.046755188111807 0.0406821275651354 8.383495145631068 33.63106796116505 0.9005425082235603 0.4380439374186179 3.633517034002208 4.6602851932859135 0.9766631781348049 0.3531801259598526 0.0183925714952033 1.0 0.68527292971009 0.160244095486996 0.0634248993381599 diff --git a/protein_atlas_molecular_function/metrics.json b/protein_atlas_molecular_function/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..cecadc50f562a0a46dc0ca84b5c9c879b07449c3 --- /dev/null +++ b/protein_atlas_molecular_function/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3120, + "annotations_size": 96, + "title": "Average number of proteins per term", + "value": 37.895833333333336 +} \ No newline at end of file diff --git a/protein_atlas_molecular_function/paths.json b/protein_atlas_molecular_function/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..0c02d490fd5f66d544ebdf2579c6011bfdc87ae6 --- /dev/null +++ b/protein_atlas_molecular_function/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_molecular_function/fragment/C390/C390_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_molecular_function/result.tsv b/protein_atlas_molecular_function/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..cc346ea59fce0ede16407e052ce05e3875f0371a --- /dev/null +++ b/protein_atlas_molecular_function/result.tsv @@ -0,0 +1,21 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Receptor 0.6824009442914948 3.746831503184133 0.0001790822903517 0.0170464757360188 0.0085959499368862 38 Q99720,Q15375,O15118,Q9NS69,P35613,Q99623,P11279,P10586,Q14108,P78310,P24390,Q14739,P30825,Q9UBG0,P11717,P05556,Q9Y5M8,P20645,Q8WTV0,Q9Y2W1,Q15758,O15031,Q14118,O75787,P02786,O00264 26 +Translocase 0.5908438425189074 2.523911239988142 0.0116057227644408 0.6739371425559958 0.085920923407458 24 P08183,P16615,P98194,Q13423,P20020,P05023,Q04656,P23634,Q9HD20,P35670,P00403 11 +Host cell receptor for virus entry 0.6526503522618425 2.4330586406700534 0.0149718759165773 0.764999642009526 0.0915204448919676 16 Q14108,Q8WTV0,O15118,P35613,P11279,P78310 6 +Carboxypeptidase 0.8649535183540722 2.42077880217602 0.0154872980184923 0.7765156715837309 0.0915204448919676 6 P42785,Q9HB40,Q9H3G5 3 +Glycosidase 0.6154497168072197 2.363291386880207 0.0181134213848686 0.8270633364675635 0.0915204448919676 18 P06280,P08236,Q9BTY2,P10253,P04062,P04066,P16278,P54802,P06865 9 +Porin 0.9058151096950652 2.128696365717083 0.0332793897230625 0.9611944480772672 0.145219155155182 4 P21796,Q9Y277 2 +Glycosyltransferase 0.4898165734510141 2.046755188111807 0.0406821275651354 0.9814474582214958 0.1698036628805653 31 O43505,Q10472,Q9BT22,P46977,P04062,P43490,Q9BV10,Q96L58,Q11206 9 +Protease 0.4175511515245542 1.9312423013094784 0.0534530950208298 0.9948755717388572 0.2044206476606697 80 O14773,P28074,Q9H300,O75976,Q92643,P45974,Q96FZ2,P42785,Q9HB40,Q4J6C6,Q16740,Q9UIQ6,Q9H3G5,Q9Y4W6,P09960,P55786,O75844,P10619,P42892,Q96E52,Q9NZ08,Q96K76,Q96RU2,Q15005,Q8TCT9,Q5JRX3 26 +Metalloprotease 0.4954419894698738 1.914169662724506 0.0555984807240665 0.9958786357629013 0.2044206476606697 27 Q96E52,Q9NZ08,O75976,P55786,Q9UIQ6,O75844,Q5JRX3,P42892 8 +Guanine-nucleotide releasing factor 0.5106566935889557 1.4564463223996469 0.1452692780683184 0.9999997144947036 0.3769148836367181 15 Q02818,Q14185,Q9BXI6,P80303 4 +Monooxygenase 0.8678567890749145 1.3194918340351498 0.1870047383414794 0.9999999976641262 0.4488113720195507 3 Q6UW02 1 +Serine protease 0.5269732012023485 1.1952941063580844 0.2319721416411861 0.9999999999900874 0.4914422735634094 10 O14773,Q4J6C6,Q9H300,Q16740 4 +Calcium channel 0.8470173187940992 1.1649062006659914 0.2440569633002489 0.9999999999978376 0.4914422735634094 2 Q9UM00 1 +Acyltransferase 0.3646939590880379 0.9724753954079216 0.3308140995751014 1.0 0.5571605887580656 36 Q96N66,Q8NF37,Q9BWD1,O15269,P23786,Q8NCC3,P50416 7 +Threonine protease 0.7384942874714464 0.8218089530834357 0.4111856373929312 1.0 0.6195413360477126 3 P28074 1 +Muscle protein 0.4717405266538264 0.5729993694740257 0.5666451208990129 1.0 0.7253057547507364 6 P09493,Q05682,P60660,P67936,P06753 5 +Ion channel 0.4323111398814404 0.5481626571198046 0.5835802207281753 1.0 0.7285533263196027 8 Q9BVC6,Q9UM00,Q4KMQ2,Q8NE86,Q8TDW0 5 +Aminopeptidase 0.3615816526569779 0.314658258472683 0.7530211403541416 1.0 0.8405817380697395 11 P55786,Q9UIQ6 2 +Dioxygenase 0.3070495453301763 0.1030036718801 0.9179600567181658 1.0 0.9683974224719112 14 Q32P28,Q9NVH6 2 +Protein phosphatase inhibitor 0.358563181526617 0.0197855454842716 0.9842144486602916 1.0 1.0 2 Q96C90 1 diff --git a/protein_atlas_molecular_function/selections.json b/protein_atlas_molecular_function/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..5ff1ac009b0666361c50ce8c165db959e949468c --- /dev/null +++ b/protein_atlas_molecular_function/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin capping", "Actin-binding", "Activator", "Acyltransferase", "Allosteric enzyme", "Aminoacyl-tRNA synthetase", "Aminopeptidase", "Aminotransferase", "Antibiotic", "Antimicrobial", "Antioxidant", "Aspartyl protease", "Blood group antigen", "Calcium channel", "Calmodulin-binding", "Carboxypeptidase", "Chaperone", "Chloride channel", "Chromatin regulator", "Cyclin", "Cytokine", "DNA-binding", "DNA-directed DNA polymerase", "Decarboxylase", "Developmental protein", "Dioxygenase", "Dipeptidase", "Elongation factor", "Endonuclease", "Excision nuclease", "Exonuclease", "Fungicide", "GTPase activation", "Glycosidase", "Glycosyltransferase", "Growth factor", "Guanine-nucleotide releasing factor", "Helicase", "Heparin-binding", "Hormone", "Host cell receptor for virus entry", "Hydrolase", "IgE-binding protein", "Initiation factor", "Integrin", "Ion channel", "Isomerase", "Kinase", "Ligase", "Lyase", "Metalloenzyme inhibitor", "Metalloprotease", "Methyltransferase", "Mitogen", "Monooxygenase", "Motor protein", "Multifunctional enzyme", "Muscle protein", "Myosin", "Nuclease", "Nucleotidyltransferase", "Oxidoreductase", "Peroxidase", "Phospholipase A2 inhibitor", "Porin", "Prenyltransferase", "Protease", "Protease inhibitor", "Protein kinase inhibitor", "Protein phosphatase", "Protein phosphatase inhibitor", "Protein synthesis inhibitor", "RNA-binding", "Receptor", "Repressor", "Ribonucleoprotein", "Ribosomal protein", "Rotamase", "Serine esterase", "Serine protease", "Serine protease inhibitor", "Serine/threonine-protein kinase", "Signal transduction inhibitor", "Thiol protease", "Thiol protease inhibitor", "Threonine protease", "Topoisomerase", "Transducer", "Transferase", "Translational shunt", "Translocase", "Tumor antigen", "Tyrosine-protein kinase", "Voltage-gated channel", "rRNA-binding", "tRNA-binding"], "available_proteins": ["AAMP", "AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFG3L2", "AGFG1", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AK4", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALG9", "ALKBH5", "ANKHD1", "ANLN", "ANO6", "ANP32B", "ANP32E", "ANXA1", "ANXA2", "ANXA3", "APEH", "APEX1", "APRT", "AQR", "ARFGAP1", "ARG2", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID4B", "ARIH1", "ARIH2", "ARL8B", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC3", "ASF1A", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD2", "ATG3", "ATG4B", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5B", "ATP6AP2", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATP7A", "ATP7B", "AURKA", "B3GALT6", "B4GAT1", "BABAM2", "BAG2", "BAG5", "BAG6", "BANF1", "BAZ1B", "BCKDK", "BCLAF1", "BCS1L", "BEND3", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BPHL", "BPNT1", "BRAP", "BRCA1", "BRD1", "BRD2", "BRD3", "BRD4", "BSG", "BTF3", "BUB1B", "BUD23", "BZW1", "BZW2", "C12orf43", "CAD", "CALCOCO1", "CALD1", "CALR", "CAMK2D", "CAMK2G", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBR1", "CBX3", "CC2D1A", "CCAR1", "CCAR2", "CCDC47", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC37", "CDC42", "CDC5L", "CDIPT", "CDK1", "CDK12", "CDK16", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK5RAP2", "CDK7", "CDK9", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CELF2", "CEP290", "CFL1", "CFL2", "CGGBP1", "CHAC2", "CHAF1A", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHEK2", "CHKA", "CHMP1A", "CHORDC1", "CHP1", "CHRAC1", "CHST14", "CIRBP", "CKB", "CKMT1A*", "CLGN", "CLIC1", "CLIC4", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT3", "CNOT7", "CNOT9", "CNP", "COASY", "COLEC12", "COLGALT1", "COMT", "COMTD1", "COPA", "COPS5", "COQ8A", "CORO1C", "COTL1", "COX2", "COX4I1", "CPD", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CS", "CSDE1", "CSK", "CSNK1A1", "CSNK1E", "CSNK2A2", "CSTB", "CSTF2", "CTBP1", "CTBP2", "CTCF", "CTNNB1", "CTPS1", "CTPS2", "CTSA", "CTSC", "CUL5", "CXADR", "CXorf57", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYP20A1", "CYP51A1", "DAG1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCD", "DCP1B", "DCPS", "DCTPP1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DGCR8", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIAPH1", "DIAPH2", "DICER1", "DIEXF", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DMAP1", "DNA2", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK1", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DR1", "DRG1", "DRG2", "DST", "DSTN", "DTYMK", "DUS2", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC3", "EDF1", "EDRF1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EFL1", "EHHADH", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMOD2", "ELP3", "EMD", "EMG1", "ENAH", "ENDOD1", "ENO1", "ENO2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPHA7", "EPHX1", "EPRS", "ERAL1", "ERAP1", "ERCC3", "ERCC6L", "ERMP1", "ERO1A", "ESD", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "F11R", "FADS2", "FAH", "FAHD1", "FAM120A", "FAM208A", "FAM213A", "FAM3C", "FANCI", "FAR1", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FKRP", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FNTA", "FNTB", "FOXK1", "FOXK2", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCDH", "GCLC", "GCN1", "GDE1", "GDI1", "GDI2", "GDPD1", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GGPS1", "GLA", "GLB1", "GLDC", "GLO1", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAO1", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOT1", "GOT2", "GPAT4", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR89B", "GPT2", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSK3A", "GSK3B", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2F2", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GUF1", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD2", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAT1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCR", "HMGCS1", "HMGN1", "HMGXB4", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HTATSF1", "HTRA2", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDI1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMP3", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INF2", "INPP4A", "INTS11", "IQGAP1", "IQGAP2", "IQGAP3", "IRF2BPL", "IRS4", "ISYNA1", "ITGAV", "ITGB1", "ITPA", "IVD", "KARS", "KAT7", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0391", "KIF11", "KIF14", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC4", "KRR1", "KYAT3", "L2HGDH", "LAMP1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LCLAT1", "LCMT2", "LDAH", "LDB1", "LDHA", "LDHB", "LEMD3", "LGALS3", "LIG1", "LIG3", "LIMA1", "LIPA", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LRPAP1", "LRPPRC", "LRRC8C", "LRWD1", "LSM14B", "LSM2", "LSM4", "LSM6", "LSS", "LTA4H", "LUC7L3", "LYAR", "LYPLA1", "LYPLA2", "M6PR", "MACF1", "MAGED2", "MAN1A1", "MAN1A2", "MAN2A1", "MANF", "MAP1S", "MAP2K1", "MAP2K2", "MAP3K7", "MAPK1", "MAPK14", "MAPK3", "MARC1", "MARCH5", "MARK2", "MARS", "MAT2A", "MATR3", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCTS1", "MCU", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED16", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METAP2", "METTL1", "METTL13", "METTL3", "MFN2", "MGEA5", "MGME1", "MGST2", "MGST3", "MID1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MMAB", "MMS19", "MOGS", "MORC2", "MORF4L1", "MOV10", "MPG", "MPHOSPH10", "MPI", "MPRIP", "MPST", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL27", "MRPL3", "MRPL33", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS17", "MRPS2", "MRPS21", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSI1", "MSI2", "MSMO1", "MTA1", "MTA2", "MTAP", "MTHFD1L", "MTHFD2", "MTHFS", "MTOR", "MTPAP", "MTR", "MUT", "MVD", "MYBBP1A", "MYCBP2", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA40", "NAA50", "NADK2", "NAF1", "NAGLU", "NAMPT", "NANS", "NAP1L4", "NARS", "NAT10", "NAXE", "NCL", "NCOA5", "NCOR1", "ND5", "NDUFAF4", "NDUFAF7", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NEDD4L", "NEK9", "NELFCD", "NELFE", "NES", "NF1", "NFRKB", "NFS1", "NHP2", "NIFK", "NIP7", "NIPBL", "NISCH", "NKRF", "NKTR", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOB1", "NOC2L", "NOL11", "NOL6", "NOL8", "NOL9", "NONO", "NOP10", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NRP1", "NSA2", "NSD1", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTPCR", "NUCB1", "NUCB2", "NUDCD1", "NUDT1", "NUDT16L1", "NUDT19", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUP153", "NUP98", "NXF1", "NXN", "OAT", "OCRL", "OGDH", "OGT", "OLA1", "OMA1", "OPA1", "ORC3", "OSGEP", "OTUB1", "OTULIN", "OXCT1", "OXSR1", "P3H1", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAK1IP1", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARL", "PARN", "PARP1", "PARP2", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PCYOX1", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDSS2", "PDXDC1", "PDXK", "PEBP1", "PECR", "PELP1", "PEPD", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PHAX", "PHB2", "PHC2", "PHF5A", "PHF6", "PHGDH", "PHPT1", "PI4K2A", "PI4KA", "PIGG", "PIGK", "PIK3C2A", "PIN4", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLS1", "PLS3", "PLXNB2", "PMPCB", "PMVK", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLDIP3", "POLE", "POLE2", "POLE4", "POLG", "POLR1A", "POLR1B", "POLR2B", "POLR2G", "POLR2H", "POLR3A", "POLR3C", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPHLN1", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R14B", "PPP1R9B", "PPP4C", "PPP5C", "PPP6C", "PPT1", "PPT2", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKCD", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF31", "PRPF4B", "PRPF8", "PRPS1", "PSAT1", "PSIP1", "PSMB5", "PSMB6", "PSMB7", "PSMD10", "PSMD14", "PSMG1", "PSMG3", "PSPC1", "PSPH", "PTBP1", "PTBP2", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PTRHD1", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "RAB10", "RAB11B", "RAB18", "RAB1A", "RAB1B", "RAB23", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD50", "RALA", "RALGAPB", "RALY", "RANBP1", "RANBP2", "RANGAP1", "RAP1GDS1", "RAP2B", "RAPGEF2", "RARS", "RASA1", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM47", "RBM5", "RBM6", "RBM7", "RBM8A", "RBMX", "RBPJ", "RCC1", "RCC2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "RETSAT", "REXO4", "RFC1", "RFC3", "RHOA", "RHOT2", "RIDA", "RIOK2", "RIPK1", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF219", "RNF40", "RNMT", "RNPEP", "RNPS1", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPF1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPP30", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS27", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRAS2", "RRM1", "RRM2", "RRP1B", "RRP7A", "RRP8", "RRP9", "RSF1", "RTCA", "RTCB", "RTF1", "RTRAF", "RUVBL1", "RUVBL2", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAP18", "SAP30BP", "SARNP", "SARS", "SARS2", "SART3", "SC5D", "SCAF1", "SCAF4", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SDHA", "SDHB", "SDR39U1", "SEC61A1", "SEC63", "SENP3", "SEPHS1", "SERBP1", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETDB1", "SF1", "SF3B1", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGPL1", "SGTA", "SHMT1", "SHMT2", "SHTN1", "SIGMAR1", "SIN3A", "SIN3B", "SIRT1", "SIRT2", "SKIV2L", "SKIV2L2", "SLC1A5", "SLC27A4", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMCHD1", "SMN1*", "SMPD4", "SMS", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SOAT1", "SOD2", "SON", "SORD", "SPATA5", "SPCS2", "SPCS3", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SRCAP", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "ST3GAL4", 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sha256:c4ccf4bca8bd8b2d32f8c51eb77c674217338d99d4b6372f16b6b7f6c2bf85b2 +size 96723 diff --git a/protein_atlas_protein_class/df_merge.tsv b/protein_atlas_protein_class/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..eb5c312efec7e5641de68355fc72f8fc2004e4c1 --- /dev/null +++ b/protein_atlas_protein_class/df_merge.tsv @@ -0,0 +1,4 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Predicted membrane proteins 337 566 3.477420867859889 0.0005062624641187 204.61650485436897 563.8058252427185 3.080866334016093 0.3028099075873978 81.17076282318972 73.52280648113661 4.068861305085399 0.4187410497068249 5.851649769894e-54 2.0428617306995395e-10 1.5699260305603866e-16 1.646464041169288e-40 2.7517230863317305e-60 +CD markers 12 18 2.6370019399829503 0.0083642353243409 6.548543689320389 16.62378640776699 0.159361413045758 0.3347758559744795 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337 +CD markers 0.6579877024858194 2.6370019399829503 0.0083642353243409 0.1546362209819207 0.0280058914043901 18 P08183,P13473,P08195,Q08722,Q9UBG0,P11717,P05556,P35613,P54709,P11279,Q5ZPR3,P02786 12 +Predicted secreted proteins 0.5094031690081023 2.6354828386139983 0.008401767421317 0.1552759088745917 0.0280058914043901 51 Q15165,P84157,O94919,Q9UMX5,P80303,Q9BUR5,Q02818,Q9BTY2,Q8N128,Q08380,Q92520,Q9HB40,Q9UM22,O00584,P78310,P43490 16 +Disease related genes 0.2529430839430033 1.3147896059427604 0.1885806216483658 0.9846923858521744 0.3143010360806098 1027 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159 +Transporters 0.5443029356324116 1.2433104978662028 0.2137534372285598 0.9918496699288164 0.3288514418900921 365 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158 +Human disease related genes 0.2630425643437421 0.3548961592865501 0.7226673858855963 0.9999999999927554 0.9033342323569954 925 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183 +Candidate cardiovascular disease genes 0.3548897464427907 0.2414275222534598 0.8092237838449972 0.999999999999996 0.9520279809941145 10 Q15165 1 +FDA approved drug targets 0.3115914032028479 0.1561662280353754 0.8759019962101422 1.0 0.9732244402334912 121 P28074,Q99720,P49721,Q8N0U8,P20020,O95749,Q02127,P23786,P50416,P16615,P98194,Q14534,P04035,P00374,P05023,P07437,P00813,P21964,P20645,Q13423,P10253,Q16850,P38435,P68371 24 diff --git a/protein_atlas_protein_class/selections.json b/protein_atlas_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..3d4d6b822008bfc26aaf7dfde9954f6a1e41250a --- /dev/null +++ b/protein_atlas_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Blood group antigen proteins", "CD markers", "Cancer-related genes", "Candidate cardiovascular disease genes", "Citric acid cycle related proteins", "Disease related genes", "Enzymes", "FDA approved drug targets", "Human disease related genes", "Metabolic proteins", "Plasma proteins", "Potential drug targets", "Predicted intracellular proteins", "Predicted membrane proteins", "Predicted secreted proteins", "RAS pathway related proteins", "RNA polymerase related proteins", "Ribosomal proteins", "Transcription factors", "Transporters"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ACAA1", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADA", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGFG1", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "AKT2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALG9", "ALKBH5", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD13A", "ANLN", "ANO10", "ANO6", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "APC", "APEH", "APEX1", "API5", "APMAP", "APOO", "APOOL", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFIP1", "ARG2", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID4B", "ARIH1", "ARIH2", "ARL1", "ARL10", "ARL2", "ARL3", "ARL6", "ARL6IP1", "ARL6IP5", "ARL8B", "ARMC1", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC4", "ARPC5", "ASAH1", "ASCC1", "ASCC2", "ASCC3", "ASF1A", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATG13", "ATG3", "ATG4B", "ATIC", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATP7B", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2", "ATXN2L", "AUP1", "AURKA", "B3GALT6", "B4GAT1", "BABAM2", "BAG2", "BAG5", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS2", "BCCIP", "BCKDK", "BCL10", "BCL2L13", "BCLAF1", "BCS1L", "BEND3", "BICD2", "BIRC6", "BLMH", "BLOC1S1", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BRAP", "BRAT1", "BRCA1", "BRD1", "BRD2", "BRD3", "BRD4", "BRD7", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf43", "C12orf73", "C17orf75", "C19orf25", "C19orf70", "C1QBP", "C1orf122", "C1orf123", "C1orf35", "C2CD5", "C5orf15", "C7orf50", "C8orf33", "CAB39", "CACYBP", "CAD", "CALCOCO1", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAMSAP3", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARHSP1", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CC2D1A", "CCAR1", "CCAR2", "CCDC12", "CCDC124", "CCDC127", "CCDC138", "CCDC22", "CCDC47", "CCDC6", "CCDC8", "CCDC86", "CCDC93", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CCZ1B", "CD276", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK16", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK5RAP2", "CDK5RAP3", "CDK7", "CDK9", "CDKAL1", "CDKN2AIP", "CDR2L", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPV", "CEP170", "CEP290", "CEP44", "CETN2", "CFAP20", "CFL1", "CFL2", "CGGBP1", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHEK2", "CHERP", "CHID1", "CHKA", "CHMP1A", "CHMP2B", "CHMP3", "CHMP4B", "CHMP5", "CHMP7", "CHORDC1", "CHP1", "CHRAC1", "CHST14", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CIZ1", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT3", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COASY", "COG3", "COG7", "COG8", "COIL", "COLEC12", "COLGALT1", "COMMD1", "COMMD4", "COMMD7", "COMT", "COMTD1", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COPZ1", "COQ8A", "CORO1C", "COTL1", "COX11", "COX14", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2L", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK1E", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CTTNBP2NL", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUL7", "CUTA", "CWF19L1", "CXADR", "CXorf56", "CXorf57", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAG1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCP1B", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D5", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DERL1", "DFFA", "DGCR8", "DHCR24", "DHCR7", "DHFR", "DHODH", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIEXF", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOCK7", "DOHH", "DOLPP1", "DPF2", "DPH2", "DPM1", "DPP3", "DPP9", "DPYSL2", "DR1", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DSTN", "DTYMK", "DUS2", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYM", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECD", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFHD2", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHHADH", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "EMC1", "EMC2", "EMC3", "EMC4", "EMC7", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPHX1", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC3", "ERCC6L", "ERGIC1", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC4", "EXOC5", "EXOC6", "EXOC6B", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FADS2", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120A", "FAM129B", "FAM162A", "FAM177A1", "FAM208A", "FAM208B", "FAM210A", "FAM213A", "FAM3C", "FAM49B", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXO22", "FBXO7", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FKRP", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FNBP1", "FNBP4", "FNDC3A", "FNTA", "FNTB", "FOXK1", "FOXK2", "FOXRED1", "FRG1", "FSCN1", "FTL", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUNDC2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GATC", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLC", "GCN1", "GDAP1", "GDE1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GGH", "GGPS1", "GHDC", "GHITM", "GID4", "GIGYF2", "GINS1", "GINS2", "GINS3", "GINS4", "GIPC1", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLTP", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNAO1", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNPNAT1", "GNS", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLPH3", "GOLT1B", "GORASP2", "GOSR1", "GOSR2", "GOT1", "GOT2", "GPAT4", "GPATCH8", "GPD1L", "GPD2", "GPI", "GPKOW", "GPR107", "GPR89B", "GPRASP2", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2H4", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD2", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAT1", "HAUS1", "HAUS2", "HAUS4", "HAUS5", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCL", "HMGCR", "HMGCS1", "HMGN1", "HMGXB4", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HPS6", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFT27", "IFT88", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKG", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INCENP", "INF2", "INPP4A", "INTS1", "INTS10", "INTS11", "INTS12", "INTS14", "INTS3", "INTS8", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "IRF2BPL", "IRGQ", "IRS4", "ISCU", "ISOC1", "IST1", "ISYNA1", "ITGAV", "ITGB1", "ITPA", "ITPRIP", "IVD", "IWS1", "JAGN1", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KCTD5", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1468", "KIAA2013", "KIF11", "KIF14", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KLC4", "KLHDC4", "KNOP1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMB1", "LAMP1", "LAMP2", "LAMTOR1", "LAMTOR2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LCMT2", "LDAH", "LDB1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LGALS3BP", "LIG1", "LIG3", "LIMA1", "LIPA", "LLGL1", "LMAN1", "LMAN2", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LNPK", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC57", "LRRC59", "LRRC8C", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM4", "LSM6", "LSS", "LTA4H", "LTV1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LYPLA2", "LYRM2", "LZIC", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAIP1", "MAK16", "MAN1A1", "MAN1A2", "MAN2A1", "MANF", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4", "MAP7D1", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARK2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MCUR1", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED16", "MED23", "MED24", "MED4", "MEPCE", "MESD", "METAP2", "METTL1", "METTL13", "METTL3", "MFAP1", "MFF", "MFN2", "MFSD10", "MFSD5", "MFSD8", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIEF1", "MIF", "MINDY3", "MINPP1", "MIPEP", "MKI67", "MLEC", "MMAB", "MMGT1", "MMS19", "MOGS", "MORC2", "MORF4L1", "MOSPD2", "MOV10", "MPC2", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPP6", "MPRIP", "MPST", "MPV17L2", "MRC2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL27", "MRPL3", "MRPL33", "MRPL37", "MRPL38", "MRPL39", "MRPL4", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL49", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS17", "MRPS2", "MRPS21", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTHFD1L", "MTHFD2", "MTHFS", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MUT", "MVD", "MXRA7", "MYBBP1A", "MYCBP", "MYCBP2", "MYDGF", "MYG1", "MYH10", "MYH14", "MYH9", "MYL6", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAF1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG", "NCAPG2", "NCAPH", "NCBP1", "NCDN", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCOR1", "NCSTN", "ND5", "NDC1", "NDRG3", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA2", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF3", "NDUFAF4", "NDUFAF7", "NDUFB10", "NDUFB11", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS5", "NDUFS6", "NDUFS7", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEDD4L", "NEFL", "NEFM", "NEK9", "NELFCD", "NELFE", "NEMF", "NENF", "NES", "NF1", "NFATC2IP", "NFRKB", "NFS1", "NFXL1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP2", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP10", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPHP3", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRM", "NRP1", "NSA2", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSMCE3", "NSRP1", "NSUN2", "NSUN5", "NT5C2", "NT5C3A", "NT5C3B", "NT5DC1", "NT5DC2", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDCD3", "NUDT1", "NUDT16L1", "NUDT19", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "ODR4", "OGDH", "OGT", "OLA1", "OMA1", "OPA1", "OPA3", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP2", "PAK1IP1", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARL", "PARN", "PARP1", "PARP2", "PBDC1", "PBK", "PBRM1", "PBXIP1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK1", "PDK3", "PDLIM1", "PDLIM5", "PDS5A", "PDS5B", "PDSS2", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PHAX", "PHB", "PHB2", "PHC2", "PHF10", "PHF3", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHPT1", "PI4K2A", "PI4KA", "PICALM", "PIGG", "PIGK", "PIGS", "PIGT", "PIH1D1", "PIK3C2A", "PIK3R2", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PLXNB2", "PM20D2", "PMPCA", "PMPCB", "PMVK", "PNMA8A", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLE4", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR2L", "POLR3A", "POLR3C", "POLR3E", "POLRMT", "PON2", "POP1", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPFIA1", "PPHLN1", "PPIB", "PPIC", "PPID", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R14B", "PPP1R9B", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRELID3B", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT3", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD4", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSMG1", "PSMG3", "PSPC1", "PSPH", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTDSS2", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PTRHD1", "PUF60", "PUM1", "PUM3", "PURA", "PUS1", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB10", "RAB11B", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB1B", "RAB21", "RAB23", "RAB24", "RAB2A", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RABAC1", "RABEP1", "RABGAP1", "RABGEF1", "RABGGTA", "RABL3", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALGAPB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANGAP1", "RAP1GDS1", "RAP2B", "RAPGEF2", "RARS", "RASA1", "RAVER1", "RBBP5", "RBBP6", "RBFA", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM47", "RBM5", "RBM6", "RBM7", "RBM8A", "RBMX", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REPS1", "RER1", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT2", "RIDA", "RIF1", "RINT1", "RIOK2", "RIPK1", "RMDN1", "RMDN3", "RMND1", "RNASEH2A", "RNASET2", "RNF2", "RNF20", "RNF219", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK1", "ROCK2", "RPA1", "RPA2", "RPA3", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS27", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RPUSD3", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCA", "RTCB", "RTF1", "RTFDC1", "RTN1", "RTN2", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SBNO1", "SC5D", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCAP", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SCRN3", "SCYL2", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SEH1L", "SEL1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHCBP1", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIGMAR1", "SIN3A", "SIN3B", "SIRT1", "SIRT2", "SKA3", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC12A9", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC29A1", "SLC2A1", "SLC2A8", "SLC30A5", "SLC30A9", "SLC35B2", "SLC35F2", "SLC38A1", "SLC39A14", "SLC3A2", "SLC44A1", "SLC4A1AP", "SLC4A7", "SLC7A1", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMG5", "SMG8", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNIP1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX17", "SNX2", "SNX3", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPDL1", "SPECC1L", "SPEN", "SPR", "SPRYD7", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRFBP1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR3", "SSR4", "SSRP1", "ST3GAL4", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK26", "STK38", "STK4", "STMN1", "STOML2", "STRAP", "STRBP", "STRIP1", "STRN", "STT3A", "STT3B", "STUB1", "STX10", "STX12", "STX18", "STX4", "STX5", "STX6", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUMF2", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE1", "SYNE2", "SYNGR2", "SYNJ2BP", "TAB1", "TACC3", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TARDBP", "TARS", "TARS2", "TARSL2", "TAX1BP1", "TBC1D10A", "TBC1D10B", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TCP1", "TDP2", "TECR", "TEFM", "TELO2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFB1M", "TFCP2", "TFG", "TFRC", "TGOLN2", "THEM6", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THTPA", "THUMPD1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM13", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMM8B", "TIMMDC1", "TIPRL", "TJP1", "TJP2", "TK1", "TKFC", "TKT", "TLCD1", "TLN1", "TLN2", "TM9SF2", "TM9SF3", "TM9SF4", "TMA16", "TMBIM6", "TMCO1", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM126A", "TMEM126B", "TMEM14C", "TMEM192", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM230", "TMEM245", "TMEM33", "TMEM43", "TMEM65", "TMEM70", "TMEM87A", "TMEM97", "TMF1", "TMLHE", "TMOD3", "TMPPE", "TMTC3", "TMX1", "TMX2", "TMX4", "TNKS1BP1", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM6", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1A", "TOR1AIP1", "TOR1B", "TP53", "TP53BP1", "TPBG", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAM1", "TRAP1", "TRAPPC2L", "TRAPPC3", "TRAPPC5", "TRAPPC8", "TRIM13", "TRIM21", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIO", "TRIP10", "TRIP12", "TRIP13", "TRIP4", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSC2", "TSFM", "TSG101", "TSNAX", "TSPAN3", "TSPAN6", "TSPYL1", "TSR1", "TSR3", "TTC1", "TTC19", "TTC26", "TTC37", "TTC38", "TTC4", "TTC7B", "TTF2", "TTK", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBG1", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWF2", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNL4A", "TXNRD1", "TYMS", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAC1", "UBAP2", "UBAP2L", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBL5", "UBLCP1", "UBP1", "UBQLN2", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UFSP2", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF3B", "UQCC1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP28", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VEZT", "VIM", "VIRMA", "VKORC1L1", "VMP1", "VPS13A", "VPS13C", "VPS16", "VPS18", "VPS25", "VPS26A", "VPS26B", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS37B", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WARS2", "WBP11", "WBP2", "WDR1", "WDR12", "WDR18", "WDR26", "WDR3", "WDR36", "WDR4", "WDR41", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR7", "WDR70", "WDR73", "WDR74", "WDR75", "WDR76", "WDR77", "WDR82", "WFS1", "WIPI2", "WIZ", "WRAP53", "WTAP", "XAB2", "XPA", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YIF1A", "YIF1B", "YIPF4", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDF2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3H7B", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZDHHC6", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM2", "ZMYM4", "ZNF207", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF638", "ZPR1", "ZW10", "ZWILCH", "ZYX", "ZZZ3"], "leading_proteins": ["AAAS", "ABCB1", "ABCB7", "ACOX1", "ACP2", "ADA", "AFG3L2", "AGK", "AGPAT5", "AGPS", "AHSA1", "AIFM1", "ALDH3A2", "ALG1", "ALG12", "ALG9", "ANKLE2", "ANO10", "ANO6", "APOO", "ARL10", "ARL6IP1", "ARL6IP5", "ARMCX3", "ASAH1", "ASNA1", "ATAD3A", "ATL2", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5F1", "ATP5L", "ATP6", "ATP6AP1", "ATP6AP2", "ATP6V0A1", "ATP6V0A2", "ATP7A", "ATP7B", "AUP1", "B3GALT6", "B4GAT1", "BCAP31", "BCL2L13", "BCS1L", "BICD2", "BNIP1", "BSG", "C19orf70", "C5orf15", "CANX", "CCDC47", "CCDC6", "CCDC8", "CD276", "CD47", "CDKAL1", "CDS2", "CHMP2B", "CHST14", "CISD1", "CKAP4", "CLCN3", "CLN5", "CLPP", "CLPTM1", "CLPTM1L", "CNNM4", "COA3", "COMT", "COX11", "COX14", "COX15", "COX2", "COX4I1", "COX5A", "COX6C", "CPD", "CPT1A", "CPT2", "CTSA", "CXADR", "CYB5B", "CYB5R3", "CYP20A1", "CYP51A1", "DAG1", "DAGLB", "DCAKD", "DDRGK1", "DERL1", "DHCR24", "DHFR", "DHODH", "DIABLO", "DLD", "DNAJC1", "DNAJC11", "DNAJC16", "DNAJC3", "DOLPP1", "DYM", "ECE1", "EMC2", "EMC4", "EMC7", "EMD", "ENDOD1", "EPDR1", "EPHA7", "EPHX1", "ERGIC1", "ERGIC3", "ERLIN1", "ERLIN2", "ERO1A", "ETFDH", "FAF2", "FAM162A", "FAM177A1", "FAM210A", "FAM213A", "FAM3C", "FDFT1", "FECH", "FGFR1OP", "FKBP14", "FKRP", "FLOT1", "FOXRED1", "FUCA1", "FUCA2", "FUS", "GAA", "GALNT1", "GBA", "GDAP1", "GDE1", "GGCX", "GGPS1", "GHITM", "GLA", "GLB1", "GLG1", "GM2A", "GNS", "GOLGA5", "GOLGB1", "GOLT1B", "GOSR1", "GPR107", "GPR89B", "GUSB", "HACD3", "HEXA", "HLA-A", "HLA-C", "HM13", "HMGCR", "HMOX1", "HMOX2", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HSD17B12", "HSDL1", "HTRA2", "ICMT", "IGF2R", "IKBIP", "ILVBL", "IMMT", "IMPAD1", "INPP4A", "ITGB1", "JAGN1", "KDELR1", "KDSR", "KIAA0319L", "KIAA2013", "KPNA2", "L2HGDH", "LAMP1", "LAMP2", "LBR", "LDAH", "LEMD2", "LEMD3", "LETM1", "LGALS3BP", "LIPA", "LMAN1", "LMAN2", "LMF2", "LMNB1", "LMNB2", "LNPEP", "LPCAT1", "LRRC59", "LRRC8C", "M6PR", "MAGT1", "MAN1A2", "MAN2A1", "MBOAT7", "MCL1", "MCU", "MFF", "MFN2", "MFSD10", "MGST2", "MIA2", "MIA3", "MICU1", "MMGT1", "MOSPD2", "MPV17L2", "MRC2", "MSMO1", "MTCH1", "MTCH2", "MTDH", "MTFP1", "MTX1", "MXRA7", "NAGLU", "NAMPT", "NCLN", "NCSTN", "NDC1", "NDUFA11", "NDUFA13", "NDUFB10", "NDUFB11", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS2", "NEFL", "NENF", "NFXL1", "NNT", "NPC1", "NRM", "NSDHL", "NSMCE2", "NUCB1", "NUCB2", "NUP35", "NUP37", "NUP54", "NUP93", "OCIAD1", "OCLN", "OMA1", "OPA1", "OPA3", "OXA1L", "P3H1", "PARL", "PDE6D", "PEX14", "PEX19", "PGRMC1", "PIGG", "PIGK", "PIGS", "PIK3R2", "PISD", "PKMYT1", "PLA2G15", "PLD3", "PLD6", "PLXNB2", "PMPCA", "PON2", "POR", "PPT1", "PRAF2", "PRRC1", "PSMB2", "PSMB5", "PTDSS2", "PTGES2", "PTPN1", "PTPRF", "PTRH2", "PUF60", "PXMP2", "QSOX2", "RAB11B", "RABAC1", "RABL3", "RBM10", "RBMX", "REEP4", "REEP5", "RER1", "RETSAT", "RMDN3", "RMND1", "RNASET2", "RPN1", "RTN1", "RTN2", "RTN3", "RTN4", "SACM1L", "SAMM50", "SC5D", "SCAMP2", "SCAMP3", "SCAP", "SCARB1", "SCARB2", "SCCPDH", "SCO1", "SCO2", "SCPEP1", "SDCBP", "SDF4", "SDHB", "SEC22B", "SEC62", "SEC63", "SEL1L", "SET", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SH3GLB1", "SIGMAR1", "SLC19A1", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A32", "SLC25A4", "SLC25A6", "SLC2A8", "SLC30A5", "SLC35B2", "SLC35F2", "SLC39A14", 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--- /dev/null +++ b/protein_atlas_subcellular_location_all/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/protein_atlas_subcellular_location_all/metrics.json b/protein_atlas_subcellular_location_all/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..b75e75d3f3cc52c2feb7c0f1f76b4dca31861b83 --- /dev/null +++ b/protein_atlas_subcellular_location_all/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 3120, + "annotations_size": 33, + "title": "Average number of proteins per term", + "value": 145.5151515151515 +} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/paths.json b/protein_atlas_subcellular_location_all/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..970f99264641eb87730eec05d6b18b9d1cd94160 --- /dev/null +++ b/protein_atlas_subcellular_location_all/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_subcellular_location_all/fragment/C390/C390_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/result.tsv b/protein_atlas_subcellular_location_all/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..4cfb18cc93f0bad22d721527c809a131bc34b164 --- /dev/null +++ b/protein_atlas_subcellular_location_all/result.tsv @@ -0,0 +1,15 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Nuclear membrane 0.4003601182239662 1.9366741285341105 0.0527851901935243 0.8329679431013153 0.2903185460643839 64 O94901,Q03252,O75976,Q9H1E5,Q14728,P50402,O15260,Q5SNT2,Q9Y2U8,Q8NC56,Q9BVC6,O94919,Q8NFH5,Q7Z569,Q5JTV8,O00560,Q9UH99,Q9BTX1,Q9NRG9,Q6UW68,Q8IXM6,P20700,O95168 23 +Lipid droplets 0.6392403106609839 1.8264564774015264 0.0677815313412653 0.901352930206913 0.3195415048945364 10 Q01105,Q8NF37,Q96CS3,Q969V3 4 +Intermediate filaments 0.446456202431932 1.732184302176227 0.0832407530844299 0.9431899890685116 0.3433681064732733 34 O75718,Q3SXM5,P48681,Q99442,Q86YN1,Q16352,P07197,P08670,P07196,Q9UJX5 10 +Lysosomes 0.561803224354712 1.624579253527786 0.1042522406835686 0.9735680560085984 0.3822582158397517 13 O60749,Q8WTV0,O15400 3 +Golgi apparatus 0.4611194370149213 1.4451997662102227 0.1484017820617695 0.9950140657095832 0.3989693397170216 172 Q92896,Q8NBN3,Q8NC54,Q9H9S5,Q9UG56,Q9NWM8,Q04656,Q9NTJ5,Q8TBA6,Q16706,Q8NEY8,Q9UH62,O60637,Q13190,O15260,Q6NUQ4,Q8TDW0,P10586,O00231,P98194,O15212,Q96ND0,P80303,A1L0T0,Q9BSR8,Q02818,P50897,Q9HD45,Q8IXU6,O15127,Q9HB40,Q8TAD4,O43752,Q9NX62,Q5BJH7,Q8NCH0,Q9BV57,Q8N4Q0,Q96JB2,P24390,P04439,P83436,Q10471,Q7RTS9,Q9H0U4,O60476,Q9BRK5,Q86Y82,Q8N6T3,Q15043,P11717,Q6NUQ1,O60499,O15258,O43760,Q8IYS2,P49755,Q9H4A6,P35670,Q93050,Q8IZA0,O95070,Q96C57,Q96A49,Q6ZRP7,P55327,Q5BKZ1,Q92520,Q5VW38,P09601,Q14789,O43493,P16278,Q8TD16,Q99640,O75955 76 +Endoplasmic reticulum 0.4713539451173731 1.3882799003357849 0.1650518302402697 0.9974012526295952 0.3989693397170216 192 Q8N0U8,Q5BJF2,Q9BT22,Q96PC5,Q96KA5,Q96GC9,Q86XL3,Q9UM00,P51571,Q9P2W9,Q15041,O15269,Q96AG4,O43169,P50402,O15260,Q6NUQ4,Q8NF37,O75477,P51648,Q96HY6,P43307,Q8NHH9,Q92791,Q9NR31,Q99442,P13674,Q00765,O95197,Q9H6H4,Q13217,P35790,Q9H0U4,P27824,Q5HYI8,Q9H3G5,Q9NQC3,Q86UE4,Q9P035,O95674,Q15043,O94905,P51572,O43852,Q14257,Q9BV10,P21964,P37268,Q12981,Q6UW68,O75845,Q9UGP8,Q9H3N1,O96005,Q96A57,P04843,O95470,Q8IV08,Q9H6U8,Q70UQ0,Q16850,Q15800,Q99956,Q9BUN8,P84157,Q8TCT9,O00264,Q96A33,Q96KC8 69 +Peroxisomes 0.4983648125632288 1.3745863594877672 0.1692597198799486 0.9978003485744276 0.3989693397170216 15 O75381,Q9BY49,Q8WVX9,O15254,P22307,P40855,O43808,Q15067,O00116 9 +Centriolar satellite 0.3844359427000252 0.929100694212348 0.3528369047439641 0.9999994199658884 0.6849186974441657 25 Q15907 1 +Cytokinetic bridge 0.3288353805824762 0.4405334869297618 0.6595507642321095 0.9999999999999996 0.9028181700188656 23 Q13885,Q9BVA1,P07437,Q96TC7,P68371 5 +Microtubules 0.3023602328963506 0.4070746530908003 0.6839531591052013 1.0 0.9028181700188656 46 Q13885,Q9BVA1,Q02818,P07437,Q9BUF5,O60830,P68371 7 +Cell Junctions 0.281354499035636 0.2132350040425769 0.8311436667751835 1.0 1.0 49 Q6UW02,P43490,Q16625,O43657 4 +Endosomes 0.3205712589003348 0.1284275563230925 0.897810624929245 1.0 1.0 12 O60749,Q8IY95 2 +Focal adhesion sites 0.2764619528759736 0.0789871745224818 0.9370428244373272 1.0 1.0 27 Q9Y487,Q969Q5 2 +Mitotic spindle 0.2714054117025022 0.0251399794913907 0.979943311227125 1.0 1.0 22 P07437,Q13885,Q9BVA1,P68371 4 diff --git a/protein_atlas_subcellular_location_all/selections.json b/protein_atlas_subcellular_location_all/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..d178b03f724b7f557af2d95a4299dcb94d66b9a6 --- /dev/null +++ b/protein_atlas_subcellular_location_all/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin filaments", "Cell Junctions", "Centriolar satellite", "Centrosome", "Cytokinetic bridge", "Cytoplasmic bodies", "Cytosol", "Endoplasmic reticulum", "Endosomes", "Focal adhesion sites", "Golgi apparatus", "Intermediate filaments", "Kinetochore", "Lipid droplets", "Lysosomes", "Microtubule ends", "Microtubules", "Midbody", "Midbody ring", "Mitochondria", "Mitotic chromosome", "Mitotic spindle", "Nuclear bodies", "Nuclear membrane", "Nuclear speckles", "Nucleoli", "Nucleoli fibrillar center", "Nucleoli rim", "Nucleoplasm", "Peroxisomes", "Plasma membrane", "Rods & Rings", "Vesicles"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASS", "AATF", "ABCB1", "ABCB7", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD14B", "ACAA1", "ACAA2", "ACACA", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR1B", "ACTR2", "ADA", "ADAR", "ADD1", "ADD3", "ADI1", "ADK", "ADNP", "ADPGK", "ADPRHL2", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGFG1", "AGK", "AGL", "AGPAT1", "AGPAT5", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK4", "AKAP1", "AKAP12", "AKAP17A", "AKAP8", "AKAP8L", "AKAP9", "AKR1A1", "AKR1B1", "AKR7A2", "AKT1S1", "AKT2", "ALCAM", "ALDH18A1", "ALDH1B1", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG12", "ALG9", "ALKBH5", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC4", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKLE2", "ANKRD13A", "ANLN", "ANO10", "ANO6", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "APC", "APEH", "APEX1", "API5", "APMAP", "APOO", "APOOL", "APRT", "AQR", "ARCN1", "ARFGAP1", "ARFIP1", "ARG2", "ARHGAP17", "ARHGDIA", "ARID1A", "ARID4B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6", "ARL6IP1", "ARL6IP5", "ARMC1", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC1B", "ARPC2", "ARPC3", "ARPC5", "ASCC1", "ASCC2", "ASCC3", "ASF1A", "ASH2L", "ASNA1", "ASNS", "ASPH", "ASRGL1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATG13", "ATG3", "ATG4B", "ATIC", "ATL2", "ATP13A1", "ATP1B3", "ATP2B1", "ATP2B4", "ATP2C1", "ATP5A1", "ATP5B", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6V0A1", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATP7A", "ATP7B", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2", "ATXN2L", "AUP1", "AURKA", "BABAM2", "BAG2", "BAG5", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1B", "BCAP31", "BCAS2", "BCCIP", "BCKDK", "BCL2L13", "BCLAF1", "BEND3", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPHL", "BPNT1", "BRAP", "BRAT1", "BRCA1", "BRD1", "BRD2", "BRD3", "BRD4", "BRD7", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD23", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf43", "C12orf73", "C17orf75", "C19orf25", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C2CD5", "C5orf15", "C7orf50", "C8orf33", "CAB39", "CACYBP", "CAD", "CALCOCO1", "CALD1", "CALR", "CALU", "CAMK2D", "CAMK2G", "CAMSAP3", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CARS2", "CASK", "CAST", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CC2D1A", "CCAR1", "CCAR2", "CCDC12", "CCDC124", "CCDC127", "CCDC138", "CCDC22", "CCDC47", "CCDC6", "CCDC8", "CCDC86", "CCDC93", "CCNB1", "CCNK", "CCT2", "CCT3", "CCT4", "CCT6A", "CCT7", "CCT8", "CCZ1B", "CD276", "CD2AP", "CD2BP2", "CD3EAP", "CD47", "CDC123", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA8", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK16", "CDK2", "CDK4", "CDK5", "CDK5RAP1", "CDK5RAP2", "CDK5RAP3", "CDK7", "CDK9", "CDKN2AIP", "CDR2L", "CDS2", "CEBPZ", "CELF1", "CELF2", "CENPV", "CEP170", "CEP290", "CETN2", "CFAP20", "CFL1", "CFL2", "CGGBP1", "CHAC2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD8", "CHEK2", "CHID1", "CHKA", "CHMP1A", "CHMP2B", "CHMP5", "CHMP7", "CHORDC1", "CHP1", "CHRAC1", "CHST14", "CIAPIN1", "CIP2A", "CIRBP", "CISD1", "CISD2", "CIZ1", "CKAP2", "CKAP5", "CKB", "CLASP2", "CLCN3", "CLGN", "CLIC1", "CLIC4", "CLINT1", "CLNS1A", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT3", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG3", "COG7", "COG8", "COIL", "COLEC12", "COLGALT1", "COMMD1", "COMMD4", "COMMD7", "COMT", "COMTD1", "COPA", "COPB1", "COPB2", "COPE", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7A", "COPS8", "COQ8A", "COTL1", "COX14", "COX15", "COX4I1", "COX5B", "COX6C", "COX7A2L", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF6", "CPSF7", "CPT1A", "CPT2", "CPVL", "CRK", "CRKL", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK1E", "CSTB", "CSTF1", "CSTF2", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTPS2", "CTR9", "CTSA", "CTSC", "CTTN", "CTTNBP2NL", "CUL1", "CUL2", "CUL4B", "CUL5", "CUTA", "CWF19L1", "CXADR", "CXorf56", "CXorf57", "CYB5B", "CYB5R1", "CYB5R3", "CYC1", "CYFIP2", "CYP20A1", "CYP51A1", "DAD1", "DAG1", "DAGLB", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCP1B", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D5", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEGS1", "DEK", "DENR", "DERL1", "DFFA", "DGCR8", "DHCR7", "DHFR", "DHODH", "DHRS7", "DHRS7B", "DHTKD1", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX37", "DHX38", "DHX40", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH2", "DIAPH3", "DICER1", "DIDO1", "DIS3", "DKC1", "DLAT", "DLD", "DLG1", "DLGAP5", "DLST", "DMAP1", "DNA2", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC11", "DNAJC13", "DNAJC16", "DNAJC2", "DNAJC21", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOHH", "DOLPP1", "DPF2", "DPH2", "DPP3", "DPP9", "DPYSL2", "DR1", "DRG1", "DRG2", "DSG2", "DSP", "DST", "DTYMK", "DUS2", "DUSP12", "DUSP3", "DUSP9", "DUT", "DYM", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNC2H1", "DYNLL1", "DYNLL2", "EARS2", "EBNA1BP2", "ECD", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECSIT", "EDC3", "EDC4", "EDF1", "EDRF1", "EEA1", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFHD2", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EHMT2", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2D", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4E", "EIF4E2", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "EIF6", "ELAC2", "ELAVL1", "ELMO2", "ELMOD2", "ELOA", "ELOC", "ELP1", "ELP2", "ELP3", "EMC8", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERC1", "ERCC3", "ERCC6L", "ERGIC1", "ERH", "ERLIN1", "ERLIN2", "ERP29", "ESD", "ESF1", "ESS2", "ESYT1", "ESYT2", "ETFA", "ETFB", "EWSR1", "EXD2", "EXO1", "EXOC2", "EXOC4", "EXOC6", "EXOC6B", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC4", "EXOSC5", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120A", "FAM129B", "FAM162A", "FAM177A1", "FAM208A", "FAM208B", "FAM210A", "FAM3C", "FAM49B", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD2", "FBL", "FBXO7", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FHL1", "FHOD1", "FIP1L1", "FKBP10", "FKBP14", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FKRP", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FNBP1", "FNBP4", "FNDC3A", "FNTA", "FNTB", "FOXK1", "FOXK2", "FOXRED1", "FSCN1", "FTL", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNT2", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLC", "GCN1", "GDAP1", "GDE1", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA2", "GGPS1", "GHITM", "GID4", "GIGYF2", "GINS1", "GINS2", "GINS3", "GINS4", "GIPC1", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX5", "GLS", "GLTP", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPS", "GNA13", "GNAI1", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GOLGA2", "GOLGA3", "GOLGA5", "GOLGB1", "GOLPH3", "GOLT1B", "GORASP2", "GOSR2", "GOT1", "GPATCH8", "GPD2", "GPI", "GPKOW", "GPR107", "GPR89B", "GPRASP2", "GPS1", "GPT2", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSK3A", "GSK3B", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTZ1", "GTF2B", "GTF2E1", "GTF2F2", "GTF2H4", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GTPBP4", "GUF1", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HARS2", "HAT1", "HAUS1", "HAUS2", "HAX1", "HBS1L", "HCCS", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD3", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HGS", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMGN1", "HMGXB4", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPLL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B11", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPH1", "HTATSF1", "HTRA2", "HTT", "HUWE1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "IKBKG", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INCENP", "INF2", "INPP4A", "INTS1", "INTS10", "INTS11", "INTS12", "INTS14", "INTS3", "INTS8", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQGAP3", "IRF2BPL", "IRGQ", "ISCU", "ISOC1", "IST1", "ISYNA1", "ITGAV", "ITGB1", "ITPA", "ITPRIP", "IVD", "IWS1", "JAGN1", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDELR1", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KHDRBS1", "KHSRP", "KIAA0319L", "KIAA0368", "KIAA0391", "KIAA1468", "KIAA2013", "KIF11", "KIF14", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIN", "KLC1", "KLC4", "KLHDC4", "KNOP1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "L2HGDH", "LAMP2", "LAMTOR1", "LAMTOR2", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LCMT2", "LDB1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LIG1", "LIG3", "LIMA1", "LIPA", "LMAN1", "LMF2", "LMNA", "LMNB1", "LMNB2", "LNPK", "LONP1", "LPCAT1", "LRBA", "LRPAP1", "LRPPRC", "LRRC1", "LRRC40", "LRRC47", "LRRC57", "LRRC59", "LRRC8C", "LRWD1", "LSM12", "LSM14B", "LSM2", "LSM4", "LSM6", "LTA4H", "LTV1", "LUC7L", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LYPLA2", "LYRM2", "LZIC", "LZTFL1", "MACF1", "MAD2L1", "MAGED2", "MAIP1", "MAK16", "MAN1A1", "MAN1A2", "MAN2A1", "MANF", "MAP1B", "MAP1S", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4", "MAPK1", "MAPK14", "MAPK3", "MAPRE1", "MAPRE2", "MARC1", "MARCH5", "MARK2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAVS", "MBD3", "MBOAT7", "MCAT", "MCCC1", "MCCC2", "MCL1", "MCM10", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MCTS1", "MCU", "MDC1", "MDH1", "MDH2", "MDN1", "ME1", "ME2", "MECP2", "MED1", "MED14", "MED16", "MED23", "MED4", "MEPCE", "MESD", "METAP2", "METTL1", "METTL13", "MFAP1", "MFF", "MFN2", "MFSD10", "MFSD8", "MGEA5", "MGME1", "MGST2", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIEF1", "MIF", "MINDY3", "MIPEP", "MKI67", "MMAB", "MMS19", "MOGS", "MORC2", "MORF4L1", "MOSPD2", "MOV10", "MPG", "MPHOSPH10", "MPI", "MPP1", "MPP2", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL22", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL46", "MRPL47", "MRPL48", "MRPL50", "MRPL53", "MRPL58", "MRPL9", "MRPS11", "MRPS15", "MRPS2", "MRPS21", "MRPS22", "MRPS23", "MRPS25", "MRPS26", "MRPS27", "MRPS28", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI1", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH2", "MTDH", "MTFP1", "MTHFD1L", "MTHFD2", "MTHFS", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MUT", "MVD", "MXRA7", "MYBBP1A", "MYCBP", "MYCBP2", "MYG1", "MYH10", "MYH14", "MYH9", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA10", "NAA15", "NAA25", "NAA40", "NAA50", "NADK2", "NAE1", "NAF1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NBN", "NCAPD2", "NCAPG2", "NCAPH", "NCBP1", "NCDN", "NCKAP1", "NCKIPSD", "NCL", "NCLN", "NCOA5", "NCOR1", "NCSTN", "NDC1", "NDUFA10", "NDUFA11", "NDUFA13", "NDUFA4", "NDUFA7", "NDUFA8", "NDUFA9", "NDUFAF4", "NDUFB11", "NDUFB4", "NDUFB8", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NDUFV2", "NECAP1", "NECAP2", "NEFL", "NEFM", "NELFCD", "NELFE", "NEMF", "NES", "NF1", "NFATC2IP", "NFRKB", "NFS1", "NFXL1", "NHLRC2", "NIFK", "NIP7", "NIPBL", "NIPSNAP2", "NISCH", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NME2", "NMT1", "NNT", "NOA1", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP10", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NRBP1", "NRDC", "NRM", "NSA2", "NSD1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSRP1", "NSUN2", "NSUN5", "NT5C3A", "NT5DC1", "NTPCR", "NUB1", "NUBP2", "NUCB1", "NUCB2", "NUCKS1", "NUDC", "NUDCD1", "NUDCD2", "NUDCD3", "NUDT1", "NUDT16L1", "NUDT19", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP188", "NUP35", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCLN", "OCRL", "ODR4", "OGDH", "OGT", "OLA1", "OMA1", "OPA1", "OPA3", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OTULIN", "OXA1L", "OXCT1", "OXSR1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B2", "PAFAH1B3", "PAICS", "PAIP2", "PAK1IP1", "PAK2", "PAK4", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PARK7", "PARL", "PARN", "PARP1", "PARP2", "PBDC1", "PBK", "PBRM1", "PBXIP1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCID2", "PCK2", "PCM1", "PCMT1", "PCNA", "PCNP", "PDAP1", "PDCD11", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDHA1", "PDHB", "PDHX", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDS5A", "PDS5B", "PDSS2", "PDXDC1", "PDXK", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PGAM1", "PGAM5", "PGD", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PGRMC1", "PHAX", "PHB", "PHB2", "PHC2", "PHF10", "PHF3", "PHF5A", "PHF6", "PHGDH", "PHIP", "PHPT1", "PI4K2A", "PI4KA", "PICALM", "PIH1D1", "PIK3C2A", "PIN4", "PINX1", "PIP4K2C", "PIR", "PISD", "PITPNB", "PITRM1", "PKM", "PKMYT1", "PKN2", "PLA2G15", "PLAA", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLOD1", "PLOD2", "PLRG1", "PLS3", "PM20D2", "PMPCA", "PMPCB", "PNMA8A", "PNN", "PNO1", "PNP", "PNPLA6", "PNPT1", "POFUT1", "POGZ", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE2", "POLE4", "POLG", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR2L", "POLR3A", "POLR3C", "POLR3E", "POLRMT", "POP1", "POR", "PPA1", "PPA2", "PPAT", "PPFIA1", "PPHLN1", "PPIB", "PPID", "PPIF", "PPIG", "PPIL1", "PPIL4", "PPM1F", "PPM1G", "PPME1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP2R5E", "PPP4C", "PPP4R1", "PPP4R3A", "PPP5C", "PPP6R3", "PPT1", "PPT2", "PQBP1", "PRAF2", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRELID3B", "PREP", "PRIM2", "PRKAA2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKCD", "PRKCSH", "PRKDC", "PRKRA", "PRMT1", "PRMT5", "PRMT9", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPS1", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA4", "PSMA5", "PSMA6", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD3", "PSMD4", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSMG1", "PSPC1", "PSPH", "PTBP1", "PTBP2", "PTCD1", "PTCD3", "PTDSS1", "PTGES2", "PTGES3", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PTRHD1", "PUF60", "PUM1", "PUM3", "PUS1", "PUS7", "PWP1", "PWP2", "PYCR2", "PYGB", "PYGL", "QARS", "QDPR", "QKI", "QRSL1", "QSOX2", "QTRT2", "RAB11B", "RAB13", "RAB14", "RAB1A", "RAB1B", "RAB23", "RAB24", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB6A", "RAB7A", "RAB8A", "RABEP1", "RABGAP1", "RABGEF1", "RABL3", "RABL6", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23A", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALGAPB", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RAVER1", "RBBP5", "RBBP6", "RBFA", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM27", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM47", "RBM5", "RBM6", "RBM7", "RBM8A", "RBMX", "RBPJ", "RCC1", "RCL1", "RCN1", "RCN2", "RDH13", "RDH14", "RDX", "RECQL", "REEP4", "REEP5", "REPS1", "RER1", "RETSAT", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOA", "RHOT2", "RIF1", "RINT1", "RIOK2", "RIPK1", "RMDN1", "RMDN3", "RMND1", "RNASEH2A", "RNF2", "RNF20", "RNF219", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK2", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL32", "RPL34", "RPL35", "RPL36", "RPL36A", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS23", "RPS24", "RPS25", "RPS27", "RPS28", "RPS3", "RPS3A", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPSA", "RPUSD3", "RRAS2", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP36", "RRP7A", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSU1", "RTCA", "RTCB", "RTF1", "RTFDC1", "RTN1", "RTN2", "RTN3", "RTN4", "RTRAF", "RUFY1", "RUVBL1", "RUVBL2", "S100A10", "S100A11", "S100A13", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SBNO1", "SC5D", "SCAF1", "SCAF11", "SCAF4", "SCAMP1", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCML2", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SCRN3", "SDAD1", "SDCBP", "SDF4", "SDHA", "SDHB", "SDR39U1", "SEC13", "SEC16A", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24C", "SEC24D", "SEC31A", "SEC61A1", "SEC61B", "SEC62", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB1", "SERPINB6", "SERPINH1", "SET", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHCBP1", "SHMT1", "SHMT2", "SHOC2", "SHTN1", "SIN3A", "SIN3B", "SIRT1", "SIRT2", "SKA3", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC19A1", "SLC1A5", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A22", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC2A1", "SLC2A8", "SLC30A5", "SLC35B2", "SLC35F2", "SLC39A14", "SLC3A2", "SLC44A1", "SLC4A1AP", "SLC4A7", "SLC9A3R1", "SLFN11", "SLIRP", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC6", "SMCHD1", "SMG5", "SMG8", "SMN1*", "SMNDC1", "SMPD4", "SMS", "SMU1", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNIP1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD2", "SNRPD3", "SNW1", "SNX1", "SNX17", "SNX2", "SNX5", "SNX6", "SNX9", "SOAT1", "SOD2", "SON", "SORD", "SPAG9", "SPART", "SPATA5", "SPATA5L1", "SPC24", "SPC25", "SPCS2", "SPDL1", "SPECC1L", "SPEN", "SPR", "SPRYD7", "SPTAN1", "SPTBN1", "SPTBN2", "SPTLC1", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRFBP1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRPK1", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSR4", "SSRP1", "STAG1", "STAG2", "STAM", "STAMBP", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STAU2", "STIP1", "STK26", "STK38", "STK4", "STMN1", "STOML2", "STRAP", "STRIP1", "STRN", "STT3B", "STUB1", "STX10", "STX12", "STX18", "STX4", "STX5", "STX6", "STX7", "STX8", "STXBP3", "STXBP4", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUMF2", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SYAP1", "SYMPK", "SYNCRIP", "SYNE1", "SYNE2", "SYNGR2", "SYNJ2BP", "TAB1", "TACC3", "TAF15", "TAF6L", "TAGLN2", "TALDO1", "TARDBP", "TARS", "TARS2", "TARSL2", "TAX1BP1", "TBC1D10A", "TBC1D13", "TBC1D15", "TBC1D4", "TBC1D9B", "TBCA", "TBCB", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCOF1", "TDP2", "TECR", "TEFM", "TELO2", "TERF2IP", "TES", "TEX10", "TEX264", "TFAM", "TFCP2", "TFG", "TFRC", "TGOLN2", "THEM6", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THTPA", "THUMPD1", "THUMPD3", "THYN1", "TIA1", "TIAL1", "TIGAR", "TIMELESS", "TIMM13", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TIMMDC1", "TIPRL", "TJP1", "TJP2", "TKFC", "TKT", "TLN1", "TLN2", "TM9SF3", "TMA16", "TMCO1", "TMED10", "TMED2", "TMEM109", "TMEM126A", "TMEM126B", "TMEM192", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM230", "TMEM245", "TMEM70", "TMEM87A", "TMEM97", "TMF1", "TMLHE", "TMOD3", "TMPPE", "TMX1", "TMX2", "TMX4", "TNKS1BP1", "TNPO1", "TNPO3", "TOE1", "TOLLIP", "TOM1", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM6", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOR1A", "TOR1AIP1", "TOR1B", "TP53", "TP53BP1", "TPBG", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAP1", "TRAPPC2L", "TRAPPC3", "TRAPPC5", "TRAPPC8", "TRIM21", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIO", "TRIP10", "TRIP12", "TRIP13", "TRIP4", "TRIR", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSC2", "TSFM", "TSG101", "TSNAX", "TSPAN3", "TSPAN6", "TSPYL1", "TSR1", "TSR3", "TTC1", "TTC19", "TTC37", "TTC38", "TTC4", "TTC7B", "TTF2", "TTK", "TTLL12", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "TWF1", "TWF2", "TXLNA", "TXLNG", "TXNDC5", "TXNDC9", "TXNL1", "TXNL4A", "TXNRD1", "U2AF1", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA5", "UBA6", "UBAC1", "UBAP2", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBLCP1", "UBP1", "UBQLN2", "UBQLN4", "UBR4", "UBR5", "UBR7", "UBTF", "UBXN1", "UBXN4", "UBXN7", "UCHL5", "UCK2", "UFC1", "UFD1", "UFL1", "UFSP2", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC45A", "UNG", "UPF1", "UPF3B", "UQCC1", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "UROD", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP15", "USP24", "USP28", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAMP7", "VANGL1", "VAPA", "VAPB", "VARS1", "VARS2", "VBP1", "VCL", "VCP", "VDAC2", "VDAC3", "VEZT", "VIM", "VIRMA", "VKORC1L1", "VMP1", "VPS13C", "VPS25", "VPS26A", "VPS29", "VPS33A", "VPS35", "VPS4A", "VPS4B", "VPS51", "VPS53", "VRK1", "VRK3", "WAPL", "WARS", "WARS2", "WBP11", "WBP2", "WDR1", "WDR12", "WDR18", "WDR26", "WDR3", "WDR36", "WDR4", "WDR41", "WDR46", "WDR5", "WDR6", "WDR61", "WDR7", "WDR70", "WDR74", "WDR76", "WDR77", "WDR82", "WIPI2", "WIZ", "WRAP53", "WTAP", "XAB2", "XPA", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YIF1A", "YIF1B", "YIPF4", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDF2", "YWHAB", "YWHAE", "YWHAG", "YWHAQ", "ZADH2", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H4", "ZC3H7B", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCCHC8", "ZFR", "ZFYVE16", "ZMYM2", "ZMYM4", "ZNF207", "ZNF281", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF638", "ZPR1", "ZW10", "ZYX", "ZZZ3"], "leading_proteins": ["AAAS", "ACOX1", "ACOX3", "ADI1", "AGPS", "ALDH3A2", "ALG1", "ALG12", "ALG9", "ANAPC4", "ANKLE2", "ARFGAP1", "ARL6IP1", "ARMCX3", "ATL2", "ATP2C1", "ATP6V0A1", "ATP6V0A2", "ATP7A", "ATP7B", "BCAP31", "BICD2", "BNIP1", "BRAP", "C12orf43", "C5orf15", "CALU", "CANX", "CCDC47", "CDS2", "CHKA", "CHST14", "CLPTM1", "CLPTM1L", "COG3", "COG7", "COMT", "CPD", "CPVL", "CRTAP", "CYB5B", "CYP20A1", "CYP51A1", "DDRGK1", "DERL1", "DNAJC1", "DNAJC3", "DOLPP1", "DUSP9", "DYM", "EMD", "ENDOD1", "ERLIN1", "ERLIN2", "FAF2", "FAM210A", "FAM3C", "FAR1", "FDFT1", "FKBP14", "FKRP", "FLOT1", "GALNT2", "GLB1", "GLG1", "GOLGA5", "GOLGB1", "GOLPH3", "GPR107", "HACD3", "HLA-A", "HM13", "HMOX1", "HSDL1", "IGF2R", "IKBIP", "ILVBL", "IMPAD1", "INA", "KDELR1", "KIAA0319L", "KIAA2013", "LEMD2", "LEMD3", "LMNB1", "LMNB2", "LPCAT1", "LRRC59", "LRRC8C", "MAN1A2", "MAN2A1", "MFSD10", "MIA2", "MSMO1", "MTDH", "MXRA7", "NAMPT", "NCLN", "NDC1", "NDUFB4", "NEFL", "NEFM", "NES", "NRM", "NUCB1", "NUCB2", "NUP35", "OCLN", "P3H4", "P4HA1", "PECR", "PEX14", "PEX19", "PFDN6", "PGRMC1", "PISD", "PKMYT1", "PLD3", "PPHLN1", "PPT1", "PSMD11", "PTPRF", "QSOX2", "RAB11B", "RAB1B", "RAB24", "RABL3", "RCN2", "REEP4", "REEP5", "RER1", "RINT1", "RMDN3", "RPN1", "RTN3", "RTN4", "SACM1L", "SAR1A", "SC5D", "SCAMP2", "SCARB1", "SCP2", "SCPEP1", "SDCBP", "SDF4", "SEC62", "SEC63", "SET", "SGPL1", "SLC25A17", "SLC30A5", "SLC35F2", "SLC39A14", "SNX2", "SPTLC1", "SSR1", "SSR4", "STX10", "STX12", "STX18", "STX5", "STX6", "STX7", "SUN1", "SUN2", "SURF4", "SYAP1", "SYNGR2", "TGOLN2", "TIMM17B", "TM9SF3", "TMCO1", "TMED10", "TMEM109", "TMEM192", "TMEM201", "TMEM205", "TMEM214", "TMEM230", "TMEM87A", "TMEM97", "TMX1", "TMX4", "TOR1AIP1", "TPD52", "TSPAN3", "TSPAN6", "TUBB", "TUBB2A", "TUBB2B", "TUBB4B", "TUBB6", "VIM", "VKORC1L1", "VMP1", "YIF1A", "YIF1B", "YIPF4", "ZADH2", "ZNF326"]} \ No newline at end of file