Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 0.5674309935647484 4.166853150426249 3.088333017942091e-05 0.0421680279127131 0.0035901871333577 69 P00403,O75964,O75947,O96000,P13073,P25705,O43676,Q7L592,O95182,P22695,P03886,Q8N183,O95168,P20674,Q9UDW1,O75306,P48047,Q9P0J0,P24539,P00846,P06576,Q16718,P31930,Q9Y6M9,O75880,O14949,P14927 27 Mitochondrial protein import 0.6663977819115184 3.849526297570161 0.0001183464777632 0.1521937146370454 0.0110580624716115 36 O60830,P12235,Q15388,Q99595,Q13505,Q8N4H5,Q9NX63,P21796,Q9NS69,P06576 10 The citric acid tca cycle and respiratory electron transport 0.4916630312251556 3.848375092408297 0.0001189038975442 0.1528527912092611 0.0110580624716115 101 P00403,O75964,O75947,O96000,P25705,P13073,P21796,O43676,Q7L592,O95182,P22695,P03886,Q8N183,O95168,P35613,P48735,O43837,Q9UDW1,P20674,O75306,P48047,Q9P0J0,P24539,P00846,Q13423,P06576,Q16718,P31930,Q9Y6M9,O75880,O14949,P14927 32 Protein localization 0.5029213743000588 3.5198099477425484 0.0004318561251361 0.4525966790251577 0.0376524559103114 76 O60830,P12235,Q15067,Q9NR77,Q99595,Q9NX63,P25705,Q13190,P14735,P21796,Q9NS69,Q8TB36,P50402,Q15388,Q13505,Q9HAV7,P51648,Q10713,O94826,O43681,P40855,O75874,P49069,P50542,P09601,O43933,O75431,O00116,Q9Y5J9,P22307,Q8N4H5,P06576 32 Respiratory electron transport 0.5066918452362601 3.441281189245783 0.0005789665267974 0.5542032724702878 0.0475093120519087 59 P00403,O96000,P13073,O43676,Q7L592,P22695,P03886,Q8N183,O95168,P20674,Q9UDW1,O75306,Q9P0J0,Q16718,P31930,Q9Y6M9,O75880,O14949,P14927 19 Copi mediated anterograde transport 0.5092459265258324 3.0979889846077553 0.0019483867055944 0.9341681000005028 0.129428545443063 53 P54920,Q13190,Q9H0U4,Q01082,Q96MW5,Q14789,O75935,P47755,O60763,Q08379,Q9Y6G9,Q9H9E3,P83436,P46459,Q14203,O95249,Q13813,Q13561,P52907 19 Organelle biogenesis and maintenance 0.4230702348934532 2.934297165081971 0.003343039741636 0.99064040311144 0.1392285541068067 102 Q8IYI6,O75964,Q9NX63,O75947,P25705,Q00059,P07900,Q13505,P30153,O75935,Q10713,P78371,Q9NQ48,P49368,Q9Y496,P48735,Q96CS2,Q14203,P61981,O75431,P48047,P24539,P62258,P00846,A0AVF1,Q9UPT5,P41208,Q16891,Q13561,Q9NV70,A6NIH7,Q04837,O94927,P06576,P50990 35 Intra golgi and retrograde golgi to er traffic 0.4231772360032638 2.868281832973611 0.0041270771940684 0.99687770143566 0.1392285541068067 99 O60499,Q9P2W9,P54920,Q13190,Q9H0U4,Q9NZ43,Q8TD16,Q5VIR6,Q07866,Q96MW5,Q9NRW7,O75935,P47755,Q9Y6G9,Q9H9E3,P83436,P46459,Q9Y496,O95721,Q14203,O95249,O15260,O43752,Q5VZE5,Q13561,P52907,Q86Y91,P33176 28 Cristae formation 0.6735184328697165 2.8638716915043023 0.0041849749448619 0.99712093665047 0.1392285541068067 20 P00846,Q13505,Q16891,O75964,Q9NX63,O75947,P25705,O75431,P48047,P24539,P06576 11 Metabolism of porphyrins 0.8707047879830924 2.8426500133021335 0.0044740170563826 0.9980796682381188 0.1392285541068067 8 P53004,P30519,P09601,P36551 4 Er to golgi anterograde transport 0.4456988915239545 2.804319946301582 0.0050422841668649 0.9991341335970833 0.1406797282555312 73 P49257,Q15436,P54920,Q13190,Q9H0U4,Q01082,Q96MW5,Q14789,O75935,P47755,O60763,Q08379,Q9Y6G9,Q9H9E3,P83436,P46459,Q14203,Q13813,Q96PC5,Q13561,P52907,Q5JRA6,Q9HCU5 23 Cooperation of prefoldin and tric cct in actin and tubulin folding 0.6702521126377297 2.7552284111870855 0.0058651174728412 0.9997269694405468 0.147783859775491 18 Q9NQP4,P49368,O15212,Q99471,O60925,P48643,Q9UHV9,P61758,P78371,Q99832,P68371,P50990 12 Cytoprotection by hmox1 0.4439029730407777 2.752866102833347 0.0059076052554891 0.9997427721370492 0.147783859775491 68 P48556,P00403,P61289,P09601,P43686,Q9UNM6,P28066,P20674,O75880,Q92530,P62195,P53004,P30519,O00231 14 Selective autophagy 0.5369689077628397 2.7200827960586644 0.0065265572305719 0.9998921088726784 0.1518480465983981 32 O60664,P50542,Q8IWA4,P07900,Q15388,Q8N4H5,O43237,Q9Y6G9,P21796,P68371,Q9NS69,O95140,P08670 13 Mitochondrial biogenesis 0.5319068807104494 2.704074499201206 0.006849493059484 0.9999314479067474 0.1566400461963967 34 P00846,Q13505,Q16891,O75964,P48735,Q9NX63,O75947,O75431,P48047,P24539,P06576,Q00059 12 Activation of bad and translocation to mitochondria 0.8333665470829341 2.67058055422979 0.0075720200488011 0.9999751626627272 0.1703704510980269 8 P27348,P63104,Q04917,P61981,P31946,P62258 6 Activation of bh3 only proteins 0.7613878962451338 2.6390609651668804 0.0083136028748136 0.999991245592611 0.1840869207994449 11 P27348,P63104,Q04917,P61981,P31946,P62258 6 Transport to the golgi and subsequent modification 0.4299169819674681 2.622364056960455 0.0087322096964908 0.9999951422228328 0.1903348832281979 75 P49257,Q15436,P54920,Q13190,Q9H0U4,Q01082,Q96MW5,Q14789,O75935,P47755,O60763,Q08379,Q9Y6G9,Q9H9E3,P83436,P46459,Q14203,Q13813,Q96PC5,Q13561,P52907,Q5JRA6,Q9HCU5 23 Smooth muscle contraction 0.7126260623837948 2.605762779760773 0.0091669925702113 0.9999973657943052 0.1967377636222285 13 P67936,P09493,P60660,Q13153,P08133,Q13177,P06753,P04083 8 Muscle contraction 0.5642367247030747 2.5984208747343 0.0093653626345728 0.9999980077447777 0.197949710230745 27 P06753,Q13177,P09493,P60660,O43865,Q13153,P08133,P67936,Q9NYL9,P08670 10 Intra golgi traffic 0.6702646326526475 2.559300862753654 0.010488292658267 0.9999995905442502 0.2120459167867025 15 Q96MW5,O95721,Q9NRW7,P54920,Q13190,O43752,Q9H9E3,P83436,P46459 9 Autophagy 0.4605018688883758 2.5366021052987997 0.0111934095739592 0.9999998485265508 0.2207526288877623 52 Q9NT62,Q8IWA4,A5D8V6,O43237,P21796,P68371,Q9H9H4,Q9NS69,O95140,Q15388,P07900,Q9NZ09,Q9Y6G9,Q9UQN3,P08670,P50542,O60664,O43633,Q8N4H5 19 Tp53 regulates metabolic genes 0.5045742375830474 2.5311045087692037 0.011370396428848 0.9999998819986052 0.2207526288877623 38 P27348,P63104,P00403,Q04917,P61981,P20674,P13073,O75880,P31946,P62258 10 Unwinding of dna 0.7858370433244747 2.509430366419201 0.0120926054858685 0.9999999574255124 0.2207526288877623 9 Q14566 1 Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex 0.7343195434432384 2.498185616676499 0.0124830812044438 0.999999975473236 0.2207526288877623 11 P27348,Q04917,P61981,P31946,P62258 5 Formation of atp by chemiosmotic coupling 0.7550302872457142 2.4766780544994833 0.0132611461016207 0.9999999918321087 0.2256012050214753 10 P00846,O75964,O75947,P25705,P48047,P24539,P06576 7 Orc1 removal from chromatin 0.4465901125655827 2.386749852564149 0.0169980526910562 0.9999999999589458 0.260574544000258 52 Q14566,P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231,O43913 10 Intrinsic pathway for apoptosis 0.5893752730545643 2.27374802892977 0.0229811406283138 0.9999999999999918 0.3374599071210289 19 P27348,Q9NR28,P63104,Q04917,P61981,P31946,Q07021,P62258 8 Generation of second messenger molecules 0.7585029558584314 2.2572605179578074 0.0239918008786099 0.999999999999998 0.3450367239758857 7 Q13153,Q8N8S7 2 Regulation of pten stability and activity 0.4601435642889047 2.2483505643319797 0.0245538448229469 0.9999999999999992 0.3462469906796512 44 P62191,P48556,P61289,P46934,Q9UNM6,P31751,P28066,Q92530,P62195,P43686,O00231 11 Collagen formation 0.6494959114142529 2.248059955569644 0.0245723670804913 0.9999999999999992 0.3462469906796512 13 O75718,Q32P28,P13674,Q15149,Q03001,O15460 6 Regulation of localization of foxo transcription factors 0.8258868895090163 2.2245349386785342 0.02611247450729 1.0 0.3577811786828648 6 P27348,P63104,P61981,P31946 4 Rhobtb gtpase cycle 0.4927089722577333 2.20066503255341 0.0277597460119538 1.0 0.3612557577319825 30 Q5VTR2,Q16643,Q12792,O43396,Q9BT78,Q16543,P78371,P12814,Q13464,P61201,P08670 11 Complex i biogenesis 0.4816440885005671 2.1705809562558636 0.0299628629216426 1.0 0.3666508225937848 31 Q16718,P03886,O96000,O75306,Q9Y6M9,Q8N183,O43676,Q9P0J0,O95168,Q7L592 10 Mitophagy 0.6347386641608652 2.1623646553353484 0.0305900796904725 1.0 0.3679359459780173 13 Q15388,P21796,Q8N4H5,Q9NS69 4 Sensory perception 0.5080130501705409 2.156143143543147 0.0310724895397789 1.0 0.3704796829742871 27 Q13813,Q12792,P47755,P52907,P09455,P35241,P26038 7 Sensory processing of sound 0.5703766338126028 2.1464893594388905 0.0318339568030288 1.0 0.3738753734921116 19 Q13813,Q12792,P47755,P52907,P35241,P26038 6 Switching of origins to a post replicative state 0.3948549387030931 2.140056303959485 0.0323502168078941 1.0 0.3738753734921116 60 Q14566,P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231,O43913 10 Late endosomal microautophagy 0.6672484052197243 2.139078226599378 0.0324293334713587 1.0 0.3738753734921116 11 O60664,O43633,A5D8V6,Q9UQN3,Q9H9H4,P08670 6 Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand 0.476575464165777 2.126287497175931 0.0334793284535341 1.0 0.3791206580849872 31 O60884,P07900,O75935,O43237,Q14203,P47755,Q13561,Q13451,Q9Y6G9,P52907,P68371,P31948 12 Pink1 prkn mediated mitophagy 0.6866461009070558 2.1238645961764586 0.0336814675924119 1.0 0.3791206580849872 10 Q15388,P21796,Q8N4H5,Q9NS69 4 Rnd3 gtpase cycle 0.5873156245880472 2.1218699005796204 0.0338486646807432 1.0 0.3791206580849872 16 P12277,Q07065,Q14254,O43396,Q86UP2,Q9NYL9,Q13464 7 Depolymerisation of the nuclear lamina 0.7072733802019988 2.1195310793020825 0.0340456100770774 1.0 0.3791206580849872 9 P20700,P02545 2 Peptide hormone metabolism 0.6262220024458285 2.112552931779141 0.0346390509479861 1.0 0.3804840635625249 13 Q8IYI6,Q15005,Q9NV70,Q8TAG9,Q9UPT5,P33176,P67812 7 Abortive elongation of hiv 1 transcript in the absence of tat 0.5864429649932617 2.048045084261684 0.0405555820306318 1.0 0.421496526173548 15 O15514 1 Rhoa gtpase cycle 0.4152549818995854 2.042599158860358 0.0410921344513279 1.0 0.421496526173548 52 P49257,Q14254,O15173,Q13190,P42166,Q96HY6,Q8NBN3,Q07021,P30519,Q9P0I2,Q13464,Q96CS3 12 Apoptosis 0.3750905763221558 2.0382398871703513 0.0415259482973766 1.0 0.4228372107652586 90 Q9UNM6,P31751,P31946,Q07021,Q15149,Q9NR28,P27348,P20700,P48556,P63104,Q04917,O60313,P43686,Q13464,P08670,P61981,P28066,Q13177,P62258,O00231,P62191,Q13813,P02545,P61289,O00429,Q92530,P62195 27 Striated muscle contraction 0.8418866805102371 2.011312790168577 0.0442924283697254 1.0 0.4327672941719258 5 P67936,P06753,P09493,P08670 4 Cellular response to chemical stress 0.3804818491349973 2.0014106038744908 0.0453481588745545 1.0 0.4327672941719258 78 P48556,P61289,P00403,P09601,P43686,Q9UNM6,P20674,P28066,O75880,Q92530,P62195,P53004,P30519,O00231 14 Signaling by erbb4 0.6949603576691413 2.0007094954219955 0.0454237055462882 1.0 0.4327672941719258 8 P16949,P46934 2 Signaling by hippo 0.7053495755546991 1.9994771770935071 0.0455567488483394 1.0 0.4327672941719258 7 Q4VCS5,P62258,P31946 3 Initiation of nuclear envelope ne reformation 0.5532392855389816 1.999045460972465 0.0456034352998373 1.0 0.4327672941719258 18 P20700,P02545,P30153,P42166,Q8IXJ6,Q86XL3,O95067 7 Synthesis of pa 0.6918243049927392 1.9849453828172317 0.0471505484237808 1.0 0.4361062405293581 8 Q9NPH0 1 Cargo trafficking to the periciliary membrane 0.5279494834397688 1.982525473059664 0.0474204592868487 1.0 0.4361062405293581 22 P49368,Q8IYI6,Q10713,P48643,Q9NV70,A6NIH7,P78371,Q8TAG9,Q9UPT5,Q9NQ48,P50990 11 Cilium assembly 0.381882303902175 1.9800647284391293 0.0476962558549216 1.0 0.4361062405293581 68 Q15154,Q8IYI6,P17612,P68371,O60645,P07900,P30153,Q15691,O75935,Q10713,P78371,P07437,Q9NQ48,Q15019,P49368,Q9Y496,Q96CS2,Q14203,P61981,P62258,Q9H6D7,P41208,A0AVF1,P48643,O94927,Q13561,Q9NV70,A6NIH7,Q8TAG9,Q9UPT5,P50990 31 Collagen biosynthesis and modifying enzymes 0.6381507391417648 1.978866782782401 0.0478310070258005 1.0 0.4361062405293581 11 P13674,O75718,O15460 3 Rhov gtpase cycle 0.5467083268941426 1.9550465236385477 0.0505775792659495 1.0 0.4465552093417695 18 Q13813,P67936,O43396,Q13153,Q13177,P06753,Q01082 7 Tcr signaling 0.4023039041604356 1.9374454619951185 0.0526909139555127 1.0 0.4522605359449503 53 P48556,P61289,P49427,Q9UNM6,Q13153,Q8N8S7,P28066,Q92530,P62195,Q13177,P43686,O00231 12 Retrograde transport at the trans golgi network 0.5290668687614447 1.9345270370193548 0.0530483611349261 1.0 0.4522605359449503 21 Q5VIR6,Q96MW5,O60664,O60499,P54920,O43752,Q9H9E3,Q5VZE5,P83436,P46459 10 Formation of the early elongation complex 0.5435265952429191 1.9335459312936192 0.0531689805698722 1.0 0.4522605359449503 18 O15514 1 Apoptotic cleavage of cellular proteins 0.5397916109505363 1.9082527847186368 0.0563585522721088 1.0 0.467179659027 18 Q13813,P20700,P02545,Q15149,Q13464,P08670 6 Golgi to er retrograde transport 0.3744650225198535 1.9053265399479855 0.0567376376348989 1.0 0.467179659027 75 Q07866,Q9Y496,O75935,Q14203,Q9P2W9,P54920,P47755,Q13561,Q9Y6G9,O15260,P52907,Q9H0U4,Q86Y91,P33176,Q9NZ43,Q8TD16,P46459 17 Sensory processing of sound by outer hair cells of the cochlea 0.5723489276048885 1.897317682192454 0.0577860226505269 1.0 0.467179659027 14 Q13813,Q12792,P15311,P35241,P26038 5 Rho gtpases activate pkns 0.5157344417535531 1.8934914946438537 0.0582925382491907 1.0 0.467179659027 22 P27348,P60660,Q04917,Q13153,P61981,P31946,P62258 7 Rhobtb1 gtpase cycle 0.5284675873093652 1.892999720138922 0.0583579066841823 1.0 0.467179659027 20 Q5VTR2,O43396,Q9BT78,P78371,Q13464,P61201,P08670 7 Stimuli sensing channels 0.6425985355655048 1.88934768775106 0.0588452555386027 1.0 0.467179659027 10 Q9C0H2 1 Programmed cell death 0.3524384006078735 1.8886282187715104 0.0589416630743742 1.0 0.467179659027 102 Q14254,Q9UNM6,P31751,P31946,Q07021,Q15149,Q05397,Q9NR28,P27348,P20700,P48556,P63104,Q04917,O60313,P43686,Q13464,P08670,P61981,P28066,Q13177,P62258,O00231,P62191,Q13813,P02545,P61289,O00429,Q92530,P62195,Q16543 30 Ctla4 inhibitory signaling 0.7490126118233098 1.8839908758322863 0.0595662096604829 1.0 0.4679548567195942 6 P30154,P30153 2 Defective cftr causes cystic fibrosis 0.4255130655186805 1.8769073196295791 0.0605307974934994 1.0 0.4679548567195942 43 P62191,P48556,P61289,Q9UNM6,P28066,Q92530,P62195,Q9UBV2,P43686,O75477,O00231,O94905 12 Formation of tubulin folding intermediates by cct tric 0.602635976110541 1.8722434803595889 0.0611729261777145 1.0 0.4679548567195942 12 P49368,P48643,Q9BVA1,Q99832,P78371,P68371,P50990 7 G2 m checkpoints 0.360939588404483 1.8611044182783325 0.0627294324061391 1.0 0.4679548567195942 92 Q14566,Q9UNM6,O60921,Q99640,P31946,P27348,P48556,P63104,P40937,Q04917,P43686,P61981,P28066,O00231,P62258,O43913,P61289,Q92530,P62195 19 Purine salvage 0.8026937457766382 1.847260267537699 0.0647094284573384 1.0 0.4801577271169525 5 P00813 1 Advanced glycosylation endproduct receptor signaling 0.6526529622455465 1.8384740964777957 0.0659925754445749 1.0 0.483104737422858 9 P17931,P14314,P47755,P52907,P09429 5 Downregulation of erbb2 signaling 0.8003559774547637 1.837397416802459 0.0661512479000969 1.0 0.483104737422858 5 Q16543,Q9UNE7,P31751,Q93034 4 Negative regulation of notch4 signaling 0.4253469946900872 1.8347382962392187 0.0665444750721724 1.0 0.483104737422858 41 P63104,P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 9 Ros and rns production in phagocytes 0.6513275624299028 1.831557159560475 0.0670174243768764 1.0 0.483104737422858 9 Q9UI12,Q9Y5K8,Q93050,P61421,P36543 5 Auf1 hnrnp d0 binds and destabilizes mrna 0.422982257560788 1.8304380785037395 0.0671844581075515 1.0 0.483104737422858 42 P62191,P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 9 Abc transporter disorders 0.4179170346627046 1.8222581568717744 0.0684158239636172 1.0 0.4894362791243387 44 P62191,P48556,P61289,Q9UNM6,P28066,Q92530,P62195,Q9UBV2,P43686,O75477,O00231,O94905 12 Ire1alpha activates chaperones 0.4793678353245165 1.805674251237775 0.0709692369350831 1.0 0.4923812797433051 25 Q969H8,P02545,Q9NWM8,Q9Y4L1,Q14999,Q14203,P43307,P61421,Q9HCU5 9 Bbsome mediated cargo targeting to cilium 0.6556050273477849 1.801099036087849 0.0716872716535887 1.0 0.4923812797433051 8 P78371,P49368,Q9NQ48,P50990 4 Regulation of runx3 expression and activity 0.4264592555005067 1.7972721354722505 0.0722924275726144 1.0 0.4923812797433051 38 P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 8 Mitochondrial calcium ion transport 0.5366406423529074 1.7937551918641643 0.072852251732105 1.0 0.4923812797433051 16 Q10713,Q9UJZ1,P21796,P45880,O95202,Q8NE86,Q96TA2,Q99623,Q8WWC4 9 Endosomal sorting complex required for transport escrt 0.5557302676328495 1.793596583576961 0.0728775822425258 1.0 0.4923812797433051 14 O75351,O43633,A5D8V6,Q9UQN3,Q9H9H4,Q9BRG1,Q9NP79 7 Creatine metabolism 0.9777711914641376 1.7862399866236345 0.0740604092456302 1.0 0.4923812797433051 2 P12277 1 Degradation of axin 0.4235340402690964 1.7689930324708203 0.0768950373442569 1.0 0.5005410043152055 38 P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 8 Cross presentation of soluble exogenous antigens endosomes 0.4235340402690964 1.7689930324708203 0.0768950373442569 1.0 0.5005410043152055 38 P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 8 Nicotinate metabolism 0.8359317049104279 1.7645626192075123 0.0776373025397345 1.0 0.5005410043152055 4 P43490 1 Class i peroxisomal membrane protein import 0.6465412905062874 1.7545986975834489 0.0793279744044008 1.0 0.5005410043152055 8 P51648,Q9NR77,P40855,Q8TB36 4 Costimulation by the cd28 family 0.5492025173486125 1.752598798385371 0.0796708976903466 1.0 0.5005410043152055 14 P30154,Q13177,Q13153,P30153 4 Degradation of dvl 0.4192989282246049 1.7419420460913144 0.0815185856518534 1.0 0.5005410043152055 39 P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 8 Darpp 32 events 0.6149149594193908 1.7392150915602476 0.081996935855662 1.0 0.5005410043152055 10 P30154,P30153,Q08209,P13861,P10644 5 Stabilization of p53 0.4183220011789961 1.7323850212156633 0.083205033122415 1.0 0.5005410043152055 39 P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 8 Heme degradation 0.979839905128966 1.7251341375121705 0.0845033017003409 1.0 0.5005410043152055 3 P53004,P30519 2 Mapk6 mapk4 signaling 0.3926037535494945 1.7192374808563773 0.0855711386250213 1.0 0.5005410043152055 50 P48556,P61289,Q9UNM6,Q13153,P28066,Q92530,P62195,Q13177,P43686,O00231 10 Cdt1 association with the cdc6 orc origin complex 0.4118885130897319 1.7189280455143288 0.0856274746970588 1.0 0.5005410043152055 42 P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231,O43913 9 Insulin processing 0.6298482367765958 1.7188617787025755 0.0856395431877774 1.0 0.5005410043152055 9 Q8IYI6,Q9NV70,Q8TAG9,Q9UPT5,P33176 5 Degradation of beta catenin by the destruction complex 0.3922936045758209 1.7158139618310708 0.0861960979413021 1.0 0.5005410043152055 50 P30154,P48556,P61289,P30153,Q9UNM6,P28066,Q92530,P49841,P62195,P43686,O00231 11 Metabolism of polyamines 0.4135933651313853 1.7011186727301526 0.0889207052405323 1.0 0.5005410043152055 40 P62191,P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P52788,P43686,O00231 10 Asymmetric localization of pcp proteins 0.4146349060392296 1.69627064786992 0.0898346365136499 1.0 0.5005410043152055 39 P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 8 Nucleotide salvage 0.6344334660801726 1.6921915210822696 0.0906094626640894 1.0 0.5005410043152055 8 P00813 1 Other interleukin signaling 0.7656630781026441 1.690078124272668 0.0910130093944951 1.0 0.5005410043152055 5 Q12846,Q15833 2 Caspase mediated cleavage of cytoskeletal proteins 0.706317187405315 1.689906872558156 0.0910457725906226 1.0 0.5005410043152055 6 Q13813,P08670 2 Regulation of ras by gaps 0.4114869773834052 1.6802659543741862 0.0929055819961939 1.0 0.5005410043152055 40 P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 8 Hedgehog on state 0.40390804317854 1.657428504943489 0.0974328723584641 1.0 0.5064394779915186 43 P48556,P61289,Q9Y496,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 9 Folding of actin by cct tric 0.6273612079722894 1.6555921118709165 0.0978044486974489 1.0 0.5064394779915186 8 P49368,P48643,Q99832,P78371,P50990 5 Heme biosynthesis 0.7552841729065466 1.6456798806212038 0.0998296833787146 1.0 0.5101187117703552 5 P36551 1 Apoptotic factor mediated response 0.6962938968253671 1.6438866256360254 0.1001996232846051 1.0 0.5101404178176067 6 Q9NR28 1 Rho gtpase cycle 0.3218020314340018 1.6226674348583074 0.1046605164179086 1.0 0.5195780085515393 167 Q5VTR2,Q07065,Q14254,P49257,Q9BXS4,Q13190,P42166,Q86XL3,Q07021,P31948,P06753,Q9NYL9,P30519,P20700,Q13505,O43396,Q13153,Q96AC1,Q96HY6,P78371,P67936,Q13464,P08670,P12277,Q16643,Q9BT78,Q13177,Q9P0I2,Q68EM7,Q8NBN3,Q96CS3,Q13813,Q12792,Q16718,O15173,Q86UP2,Q16543,P12814,P61201 39 Insulin receptor recycling 0.5915817976756801 1.61118829519692 0.1071386881826601 1.0 0.5248587977016731 10 Q9UI12,Q9Y5K8,Q93050,P61421,P36543 5 Diseases of signal transduction by growth factor receptors and second messengers 0.3079019690724594 1.6098770635979405 0.1074246971407302 1.0 0.5248587977016731 144 P30154,Q9UNM6,P31751,O15514,P31946,P06753,Q01082,P26038,P48556,P30153,Q14789,Q9NRY5,P67936,P43686,Q14203,P28066,P10644,O00231,O94905,P62191,P02545,P61289,O00291,Q92530,P62195,P49841,Q16543,P12270,P33176 29 Translocation of slc2a4 glut4 to the plasma membrane 0.4058885479971654 1.5974780701947422 0.1101591821954881 1.0 0.529903652285193 38 P27348,P63104,Q9Y496,Q04917,P61981,Q9NV70,Q12846,P31946,Q9UPT5,P62258 10 Mitotic metaphase and anaphase 0.3076291279983864 1.5938399450401342 0.1109718882001515 1.0 0.531978639310005 145 P30154,Q92674,Q15005,O43237,Q9UNM6,Q7Z3B4,P17980,Q9UQE7,P42166,P57740,Q86XL3,Q9BS16,P20700,P48556,P30153,Q8NBT2,Q9BVL2,Q9Y6G9,Q8IXJ6,P43686,P53990,P28066,Q9BTX1,Q8N1F7,Q16763,O14777,O00231,P62191,O43633,P02545,P61289,Q8WVM7,Q96EA4,Q92530,P62195,Q96BD8 36 Mitotic g1 phase and g1 s transition 0.3489545295360144 1.58650400083699 0.1126250252949314 1.0 0.5346639607364828 80 P30154,P62191,Q14566,P48556,P61289,P30153,P04818,Q9UNM6,P31751,P28066,Q92530,P62195,P43686,O00231,O43913 15 Hsf1 activation 0.522257451890381 1.5819610537764752 0.1136584616632352 1.0 0.5346639607364828 14 P07900,Q15185,Q02790,O75190,P55072,P62258 6 Budding and maturation of hiv virion 0.5507883136896008 1.567796783805714 0.1169285657367131 1.0 0.5346639607364828 12 O75351,O43633,A5D8V6,Q9UQN3,Q9H9H4,Q9NP79 6 Cargo concentration in the er 0.5353640469009434 1.5660144056906242 0.1173452446944958 1.0 0.5346639607364828 13 P49257,Q96PC5,Q13190,Q5JRA6,Q9HCU5 5 Tcf dependent signaling in response to wnt 0.3492640112483989 1.5649768450889416 0.1175883386696312 1.0 0.5346639607364828 62 P30154,P62191,P63104,P48556,P61289,Q9UBL3,P30153,Q9UNM6,P28066,Q92530,P49841,P62195,P43686,O00231 14 Hedgehog ligand biogenesis 0.39831067842779 1.564678421306136 0.1176583306352205 1.0 0.5346639607364828 41 P62191,P48556,P61289,Q9UNM6,P28066,Q92530,P62195,Q9UBV2,P43686,O00231 10 Signaling by notch4 0.392555777388577 1.5609080361730971 0.1185454509329959 1.0 0.5369185196478226 44 P63104,P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 9 Disassembly of the destruction complex and recruitment of axin to the membrane 0.6146147501148563 1.5440087523809602 0.1225862123167376 1.0 0.5473170806077046 7 P30154,P49841 2 Signaling by ctnnb1 phospho site mutants 0.6146147501148563 1.5440087523809602 0.1225862123167376 1.0 0.5473170806077046 7 P30154,P49841 2 Beta catenin phosphorylation cascade 0.6146147501148563 1.5440087523809602 0.1225862123167376 1.0 0.5473170806077046 7 P30154,P49841 2 Disorders of transmembrane transporters 0.3469023123723251 1.5411009987003446 0.123292206848667 1.0 0.5473170806077046 76 Q99567,Q9UNM6,Q7Z3B4,P17980,P48556,Q9BVL2,P43686,P35613,P28066,Q9UBV2,Q9BTX1,Q8N1F7,O75477,O00231,O94905,P62191,P61289,Q92530,P62195,P12270 20 Ncam signaling for neurite out growth 0.6127745564694103 1.534599344923029 0.1248822736803572 1.0 0.5473170806077046 7 P27361,Q13813,Q05397,Q01082 4 Regulation of cytoskeletal remodeling and cell spreading by ipp complex components 0.9146413752222884 1.5311282605789045 0.1257376965416183 1.0 0.5473170806077046 2 P12814 1 Rna polymerase iii transcription termination 0.611316237763784 1.527138598384638 0.1267265506985309 1.0 0.5473170806077046 7 O15160,P05455 2 Hiv transcription initiation 0.4959938518843481 1.5238090870754586 0.1275564089095575 1.0 0.5473170806077046 16 O15514,P52655 2 Anti inflammatory response favouring leishmania parasite infection 0.5128733065812914 1.5220526711175917 0.1279958836358543 1.0 0.5473170806077046 14 P63096,P08754,P04899,P17612,O43865,P63218,P13861,P10644,Q16539 9 Degradation of gli1 by the proteasome 0.3905522727747496 1.5206163758336673 0.128356134902944 1.0 0.5473170806077046 43 P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 8 Transcriptional regulation by runx3 0.3905439631389746 1.5205310549363895 0.1283775598468421 1.0 0.5473170806077046 43 P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 8 Regulation of tp53 expression and degradation 0.6011909206620791 1.5192953336274766 0.1286881737916323 1.0 0.5473170806077046 8 P30154,P31751,P30153 3 Fcgr3a mediated il10 synthesis 0.6666711185237609 1.506996822615403 0.1318114716420595 1.0 0.5588966654731704 6 O43865,P13861,P10644 3 Cyclin a cdk2 associated events at s phase entry 0.3871899152637192 1.5052576119500698 0.13225785845002 1.0 0.5590900379932664 44 P62191,P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 9 G1 s dna damage checkpoints 0.3917466343828522 1.4986360536850531 0.1339680741912672 1.0 0.5601218984753891 41 P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 8 Interconversion of nucleotide di and triphosphates 0.4802762151009061 1.498097044877631 0.1341080387747526 1.0 0.5601218984753891 18 Q9Y3D8,Q9H773 2 Regulation of hmox1 expression and activity 0.379878363288666 1.4951664202129558 0.1348710148655849 1.0 0.5616201653518368 47 P48556,P61289,P09601,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 9 Sema4d induced cell migration and growth cone collapse 0.604475046050869 1.4920938309487697 0.1356745489057842 1.0 0.5616201653518368 7 Q13464 1 Dectin 1 mediated noncanonical nf kb signaling 0.3887342604920628 1.4842975508821534 0.1377299997687169 1.0 0.5678888863255086 42 P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 8 Defective intrinsic pathway for apoptosis 0.4984431151950081 1.4826634159404235 0.1381638591452156 1.0 0.5678888863255086 15 P07384,P20700,P02545,Q07021,P62258 5 Opioid signalling 0.4746023918149082 1.481737351146346 0.1384101945166114 1.0 0.5678888863255086 19 P30154,P63096,P08754,P30153,P17612,Q08209,O43865,P63218,P13861,P10644 10 Regulation of mrna stability by proteins that bind au rich elements 0.3421158159902792 1.466593245699191 0.1424867385189281 1.0 0.57771600478457 66 P62191,P63104,P48556,P61289,Q14103,Q96B26,Q9UNM6,P28066,Q8IZH2,Q92530,P62195,P31946,P43686,O00231,Q01105 15 Copi independent golgi to er retrograde traffic 0.4139905028362913 1.4633643134522825 0.1433677181635526 1.0 0.57771600478457 29 O75935,Q14203,P47755,Q13561,Q9Y6G9,P52907,Q8TD16 7 Hedgehog off state 0.3545814858259166 1.462134822816412 0.143704267856807 1.0 0.57771600478457 55 P48556,P61289,Q9Y496,Q9UNM6,P28066,Q92530,P10644,P49841,P62195,P43686,O00231 11 Pten regulation 0.3411423812559946 1.4590003085112777 0.1445650227773933 1.0 0.5792926749039644 63 P62191,P48556,P61289,P46934,Q9UNM6,P31751,P28066,Q92530,P62195,P43686,O00231 11 Flt3 signaling in disease 0.710488363392291 1.4526195726549682 0.1463294086519542 1.0 0.5796377862079813 5 Q14789 1 Scf skp2 mediated degradation of p27 p21 0.3852070411809968 1.4483957953797053 0.1475063900385902 1.0 0.5796377862079813 42 P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 8 Sealing of the nuclear envelope ne by escrt iii 0.5611851936507559 1.4426684771412974 0.1491138832563359 1.0 0.5826718967579512 10 P53990,O43633,P68371,Q9UQN3 4 Abc family proteins mediated transport 0.3586492056676331 1.4361443151000377 0.150961280372124 1.0 0.5882429779863494 53 P62191,P48556,P61289,Q9UNM6,P28066,Q92530,P62195,Q9UBV2,O00231,P43686,O75477,P40855,O94905 13 Signaling by insulin receptor 0.4816225741607821 1.4272247430570129 0.153515124690883 1.0 0.5948711081771717 16 Q9UI12,Q9Y5K8,P31751,Q93050,P61421,P36543 6 Signaling by interleukins 0.313334233435631 1.4252783542543386 0.1540767546005212 1.0 0.5953935530961972 110 P30154,Q9UNM6,Q12846,P26038,P20700,P48556,P63104,P30153,P43686,O14979,P08670,O00170,P14174,P09601,P28066,Q15833,Q13177,O00231,Q13277,P62191,P61289,P52907,Q92530,P62195 24 Mitotic g2 g2 m phases 0.326708895787992 1.420339820286163 0.1555087736318983 1.0 0.5985929769079836 97 P30154,Q9UNM6,Q99640,P48556,P30153,O75935,P43686,Q96CS2,Q14203,P61981,P28066,O00231,P62258,P62191,P61289,Q13561,Q92530,P62195,O75330 19 Interferon gamma signaling 0.5555133585071284 1.411044260486512 0.1582315637447608 1.0 0.6042529528217887 10 P42224,P10321,P04439,Q12899 4 Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip 0.8844101956135154 1.4085497730006848 0.1589683395595673 1.0 0.6042529528217887 2 P67812 1 Synthesis secretion and deacylation of ghrelin 0.8844101956135154 1.4085497730006848 0.1589683395595673 1.0 0.6042529528217887 2 P67812 1 Regulation of runx2 expression and activity 0.375643216251142 1.4049541238882215 0.1600349205400935 1.0 0.6045631803328897 45 P62191,P48556,P61289,Q9UNM6,P28066,Q92530,P49841,P62195,P43686,O00231 10 Epha mediated growth cone collapse 0.5786546045252852 1.4009907202964118 0.1612168480887705 1.0 0.6045631803328897 8 Q13464 1 Nuclear signaling by erbb4 0.745674026048992 1.3962302974568557 0.162645155862497 1.0 0.6061590307859122 4 P16949 1 Nuclear envelope ne reassembly 0.3657074184911438 1.3928652403387591 0.1636605453702577 1.0 0.606858476673709 49 P20700,P02545,O43633,P30153,P53990,Q7Z3B4,Q9BVL2,Q8N1F7,P42166,Q8IXJ6,P57740,P68371,Q86XL3,Q9UQN3,O95067,Q9BTX1,P50402 17 Sulfide oxidation to sulfate 0.8802608180201545 1.391730419488504 0.1640040471010668 1.0 0.606858476673709 2 Q9UBX3 1 Signaling by erbb2 0.5509447099331897 1.385537455935594 0.1658881876242692 1.0 0.610756522572517 10 P07900,P31751,Q16543,Q9UNE7,Q93034 5 Aurka activation by tpx2 0.3853398294162081 1.3782626009734216 0.1681222255683487 1.0 0.610756522572517 36 Q15154,P41208,P07900,P30153,P17612,O75935,Q15691,Q96CS2,Q14203,P61981,Q13561,O75330,P68371,O94927,P62258,Q9H6D7 16 Mtorc1 mediated signalling 0.5647317757401531 1.3712616378797062 0.1702934097982766 1.0 0.6170371601781713 9 P23588 1 Extra nuclear estrogen signaling 0.5019127917780604 1.3590821266238933 0.1741205658659916 1.0 0.6276439002146211 13 P27361,P63096,P08754,P07900,P63218,P31751,Q99873,Q05397 8 Asparagine n linked glycosylation 0.2997813256059574 1.3555074673457443 0.1752559310845285 1.0 0.6301083089250447 117 P49257,Q86YN1,Q15436,P54920,Q13190,P04843,Q9H0U4,Q01082,Q96MW5,Q04323,P14314,Q14789,O75935,P47755,O60763,Q08379,Q9Y6G9,Q9H9E3,P83436,P46459,Q14203,O95249,P54727,Q9UBV2,P62191,Q13813,Q96PC5,Q13561,P52907,Q06210,Q9HCU5,Q5JRA6,P30101,Q16222 34 Transcriptional regulation by runx2 0.3474195941434647 1.3403478481279312 0.180132282340109 1.0 0.6410319741440104 54 P62191,P48556,P61289,Q9UNM6,P31751,P28066,Q92530,P49841,P62195,P43686,O00231 11 Dna damage recognition in gg ner 0.467834376398041 1.334156696477695 0.1821525079755215 1.0 0.6434471140514323 16 P54727,Q99627,Q9BT78,P61201 4 Platelet sensitization by ldl 0.6295613331925728 1.3340279321222728 0.1821947025450292 1.0 0.6434471140514323 6 P30154 1 Chaperone mediated autophagy 0.6278159354785668 1.3258636933779735 0.1848848508876104 1.0 0.6480260477090868 6 P07900,P08670 2 Nicotinamide salvaging 0.8704553880664817 1.3136926569740943 0.1889496530531405 1.0 0.6494113901115658 3 P43490 1 Signaling by flt3 fusion proteins 0.7253285282563714 1.3124342817995134 0.1893736462803743 1.0 0.6494113901115658 4 Q14789 1 Pyruvate metabolism and citric acid tca cycle 0.3794873960586912 1.310084767440609 0.1901671609066191 1.0 0.6494113901115658 34 P35613,O43837,P48735,P21796 4 Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.4559191560337431 1.3093940610116668 0.190400902190416 1.0 0.6494113901115658 17 Q15293,Q07065,Q86UP2,Q5JRA6,O43852 5 Negative regulators of ddx58 ifih1 signaling 0.5605333994256092 1.3053977118113589 0.1917574571416631 1.0 0.6519676298528766 8 Q7Z434,Q14258,Q9UII4 3 Rap1 signalling 0.723206341685316 1.3036880694447204 0.1923399588635075 1.0 0.6519676298528766 4 P63104,P31946 2 Copii mediated vesicle transport 0.3957389581365198 1.3030653645565908 0.1925524469529642 1.0 0.6519676298528766 29 Q9Y6Y8,P49257,Q15436,Q9Y296,P54920,Q08379,O60763,Q13190,Q9H0U4,O15027,P49755,Q9HCU5,P46459 13 Vitamin b2 riboflavin metabolism 0.8565500889152344 1.2957345353601868 0.1950669588477387 1.0 0.6541307874822007 2 Q969G6 1 G protein mediated events 0.5165943639479655 1.285047889337033 0.1987755497679693 1.0 0.656990702450012 11 P63096,P08754,P17612,O43865,P13861,P10644 6 Nephrin family interactions 0.5481148669732361 1.281521762283793 0.2000104610448896 1.0 0.656990702450012 9 P12814,Q13813,Q01082 3 Pka mediated phosphorylation of creb 0.7169788243074152 1.2780201224409509 0.2012423312740019 1.0 0.656990702450012 4 P10644,P13861 2 Pka activation in glucagon signalling 0.7169788243074152 1.2780201224409509 0.2012423312740019 1.0 0.656990702450012 4 P10644,P13861 2 Creb1 phosphorylation through the activation of adenylate cyclase 0.7169788243074152 1.2780201224409509 0.2012423312740019 1.0 0.656990702450012 4 P10644,P13861 2 Citric acid cycle tca cycle 0.4483451359664924 1.2738719676979968 0.2027087945068821 1.0 0.656990702450012 18 P48735,O43837 2 Gamma carboxylation hypusine formation and arylsulfatase activation 0.5459958681457475 1.2700610999547268 0.2040628667210424 1.0 0.656990702450012 9 P63241,P49366,P38435,O60725 4 Cooperation of pdcl phlp1 and tric cct in g protein beta folding 0.5009688808916223 1.2695877886140712 0.2042315014469953 1.0 0.656990702450012 12 P49368,P67870,P48643,P63218,P78371,Q99832,P50990 7 Rho gtpases activate rocks 0.5005056898361415 1.2668000739073513 0.2052267856806433 1.0 0.656990702450012 12 P60660,Q13464 2 Dna replication pre initiation 0.3266508691180728 1.264890459982183 0.2059105976533619 1.0 0.656990702450012 67 Q14566,P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231,O43913 10 Uch proteinases 0.3600016941796745 1.260216190627831 0.2075913837543266 1.0 0.656990702450012 46 P48556,P61289,Q9Y4E8,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 9 Activation of atr in response to replication stress 0.4247558569347049 1.2595813898755286 0.2078204124604918 1.0 0.656990702450012 23 Q14566,O60921,P40937 3 Cellular response to hypoxia 0.3656810760755844 1.2494114219690602 0.2115146329113084 1.0 0.6618735573620639 42 P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 8 Protein folding 0.3704489657926911 1.2415395639704605 0.2144064920316162 1.0 0.6668859190594372 37 Q9NQP4,P49368,O15212,P63218,Q99471,O60925,Q9UHV9,P78371,P61758 9 Ion channel transport 0.3886699265910665 1.2408898695819623 0.2146464355969084 1.0 0.6668859190594372 29 Q9UI12,Q99576,Q9Y5K8,Q93050,P61421,Q9C0H2 6 Esr mediated signaling 0.3575239806712085 1.2339122168984664 0.2172356166304374 1.0 0.6734304115543561 46 Q13547,P04899,P19388,P31751,O15514,Q9UQE7,Q13451,Q05397,P52655,P07900,Q9HCL2,Q8N3U4,Q99873,P08754,Q15185,P63218,P27361,Q13951,P63096,Q8WVM7,Q08752 21 Vitamin d calciferol metabolism 0.8487764935693782 1.232037709404939 0.2179349980985367 1.0 0.6740551697035031 3 P38435 1 Meiotic synapsis 0.4519293790164714 1.226483166542749 0.2200169061774801 1.0 0.676424155430508 16 P20700,P02545,Q9UH99 3 Iron uptake and transport 0.4411345662810961 1.2230461938975998 0.2213122493672203 1.0 0.6766296718765018 18 Q9UI12,P09601,Q9Y5K8,Q93050,P61421,P30519 6 Recruitment of numa to mitotic centrosomes 0.3646216151500699 1.2128034192590622 0.2252049878367121 1.0 0.6829586044178554 40 Q15154,Q9BSJ2,P41208,P07900,P17612,P30153,O75935,Q15691,Q96CS2,Q14203,P61981,Q9BVA1,Q13561,P68371,P07437,O94927,P62258,Q9H6D7 18 Runx1 regulates transcription of genes involved in differentiation of hscs 0.360143028215807 1.2077657875994534 0.22713736472015 1.0 0.6853060984423669 43 P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 8 Anchoring of the basal body to the plasma membrane 0.3669730381746615 1.2077099317444884 0.2271588564377358 1.0 0.6853060984423669 37 Q15154,P41208,P07900,P30153,P17612,O75935,Q15691,Q96CS2,Q14203,P61981,Q13561,P68371,O94927,P62258,Q15019,Q9H6D7 16 Aggrephagy 0.4538082076453473 1.188206579739626 0.2347520320667202 1.0 0.6960002914647514 15 P07900,O43237,Q9Y6G9,P68371,P55072,P08670 6 Copi dependent golgi to er retrograde traffic 0.3447447596550471 1.1875933810830526 0.2349936467956257 1.0 0.6960002914647514 50 Q07866,Q9Y496,Q9P2W9,P54920,O15260,Q9H0U4,Q86Y91,Q9NZ43,P33176,P46459 10 Signaling by hedgehog 0.3186056793664443 1.1821390810941703 0.2371505196964189 1.0 0.6994185517473668 60 P48556,P61289,Q9Y496,Q9UNM6,P28066,Q92530,P10644,P49841,P62195,P43686,O00231 11 Golgi cisternae pericentriolar stack reorganization 0.485770064933708 1.17806781988275 0.2387695698834639 1.0 0.7027079113658908 12 P27361,P61019,Q08379,O60763,Q9H0U4,O95067,P06493 7 Adora2b mediated anti inflammatory cytokines production 0.5135787365778366 1.176178987455366 0.2395233593484165 1.0 0.7034422869285074 10 P63096,P08754,P17612,P63218,P13861,P10644 6 Fc epsilon receptor fceri signaling 0.327038081108773 1.1704460745360954 0.2418215032088029 1.0 0.70869957347958 56 P48556,P61289,P49427,Q9UNM6,Q13153,P28066,Q92530,P62195,Q13177,P43686,O00231 11 Ras processing 0.6448309459863175 1.167171700945098 0.2431410367334825 1.0 0.7102575162299525 5 O75608,O60725 2 C type lectin receptors clrs 0.3294909755409442 1.1640015026539612 0.2444234028149632 1.0 0.7103246007457477 55 P48556,P61289,P49427,Q9UNM6,Q13153,P28066,Q92530,P62195,Q13177,P43686,O00231 11 Type i hemidesmosome assembly 0.8212803793716661 1.1536751962253122 0.2486333566086922 1.0 0.714569766098979 2 Q15149 1 Assembly of collagen fibrils and other multimeric structures 0.8212803793716661 1.1536751962253122 0.2486333566086922 1.0 0.714569766098979 2 Q15149 1 Platelet homeostasis 0.4938147262940907 1.152360393746598 0.2491730090905837 1.0 0.714569766098979 11 P30154,P63218 2 Attenuation phase 0.493263406251695 1.1491488453937817 0.2504946100678147 1.0 0.7146107845418008 11 Q02790,O75190,P07900,Q15185 4 Constitutive signaling by akt1 e17k in cancer 0.6394368905431784 1.143711107405388 0.2527434654160063 1.0 0.7168952187122198 5 P49841 1 Intracellular signaling by second messengers 0.3152081870882742 1.140512068495153 0.2540730276778684 1.0 0.718928749717295 84 P30154,P62191,P48556,P61289,P30153,P46934,Q9UNM6,P31751,P28066,Q92530,P62195,Q9UNE7,P49841,P10644,P43686,O00231 16 Cell cycle checkpoints 0.2876956580351812 1.1388706605708017 0.2547571044290777 1.0 0.7189906251473349 153 P30154,Q14566,Q15005,Q9UNM6,O60921,Q99640,P31946,Q9BS16,P27348,P48556,P63104,P40937,P30153,Q04917,Q8NBT2,P43686,P61981,P28066,O14777,O00231,P62258,O43913,P61289,Q96EA4,Q92530,P62195,Q96BD8 27 Formation of tc ner pre incision complex 0.3721935827300504 1.1379874910105916 0.2551257056974414 1.0 0.7189906251473349 30 Q9UMS4,O15514,Q99627,Q9BT78 4 Hiv elongation arrest and recovery 0.4083516164443838 1.1327109280986287 0.257335666968411 1.0 0.721241394773412 23 O15514 1 Recruitment of mitotic centrosome proteins and complexes 0.3584127144257846 1.1245249951807506 0.2607903729126293 1.0 0.7239599526218454 37 Q15154,Q9BSJ2,P41208,P07900,P17612,P30153,O75935,Q15691,Q96CS2,Q14203,P61981,Q13561,P68371,O94927,P62258,Q9H6D7 16 Rhog gtpase cycle 0.3594461243617708 1.1234200313365932 0.2612591462904228 1.0 0.7239599526218454 35 P49257,Q16718,O15173,Q13190,P42166,Q86XL3,Q13177 7 Glucuronidation 0.8193706153729896 1.1217153941427942 0.2619834690702505 1.0 0.7239599526218454 3 Q9NUJ1 1 Incretin synthesis secretion and inactivation 0.8193107444606602 1.1214915354950978 0.2620786925261877 1.0 0.7239599526218454 3 P67812 1 Synthesis secretion and inactivation of glucagon like peptide 1 glp 1 0.8193107444606602 1.1214915354950978 0.2620786925261877 1.0 0.7239599526218454 3 P67812 1 Hiv transcription elongation 0.3873097578677182 1.119304769094844 0.2630101419475292 1.0 0.7242667444053545 26 O15514 1 Synthesis of active ubiquitin roles of e1 and e2 enzymes 0.4880512280148568 1.1187937735489335 0.2632281286118385 1.0 0.7242667444053545 11 Q96BN8,P49427,P60604 3 Gene and protein expression by jak stat signaling after interleukin 12 stimulation 0.39904746327937 1.107467197970198 0.2680919867165827 1.0 0.727125081648511 24 P20700,O00170,P14174,P52907,O14979,P26038 6 Raf activation 0.4859686081796255 1.106669473676196 0.2684368580996294 1.0 0.727125081648511 11 P30154,P31946,P30153 3 Rhod gtpase cycle 0.3728468903724933 1.101887536780248 0.2705105675750823 1.0 0.7288712659598194 29 Q16643,P20700,P49257,O60879,O15173,P42166,P12814,O60610,Q68EM7 9 Rho gtpase effectors 0.2721842057781796 1.1014740053277845 0.270690411962708 1.0 0.7288712659598194 130 P30154,Q92674,Q15005,O43237,P31946,Q05397,Q9BS16,Q07866,P27348,P63104,P30153,Q04917,Q13153,Q8NBT2,Q9Y6G9,Q13464,P35580,P60660,P61981,Q9H0B6,Q13177,O14777,P62258,O43663,O60879,Q96EA4,Q86UP2,Q96BD8,P33176 29 Regulation of glycolysis by fructose 2 6 bisphosphate metabolism 0.6292067384939355 1.0992603349999557 0.2716545282666467 1.0 0.7288712659598194 5 P30154,P30153 2 S phase 0.3034585834089088 1.0947824659210756 0.2736119499156602 1.0 0.730210619797081 99 Q14566,Q9UNM6,P31751,Q9UQE7,P48556,P40937,Q9BRT9,P43686,P49643,P28066,Q16763,O00231,O43913,P62191,P61289,Q8WVM7,Q92530,P62195,P49841,P49005 20 Arms mediated activation 0.8064611736810912 1.0944290778095611 0.2737668367376498 1.0 0.730210619797081 2 P31946 1 Amino acids regulate mtorc1 0.4716599006201431 1.0931246309462626 0.2743390828287486 1.0 0.730210619797081 12 P61421,Q9UI12,Q9Y5K8 3 Tnfr2 non canonical nf kb pathway 0.3488883983426781 1.0923379210242727 0.2746845983012118 1.0 0.730210619797081 43 P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 8 Rac2 gtpase cycle 0.3548409744487029 1.0840687664932087 0.2783343100224731 1.0 0.7367672912359583 36 P49257,Q13505,Q13153,O15173,P42166,Q86XL3 6 Phase i functionalization of compounds 0.4568863224812701 1.0785647391983453 0.2807818072452632 1.0 0.7415612373150542 13 O43169,P07099 2 Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.4689853491942843 1.0770403528633588 0.2814622384376497 1.0 0.7415612373150542 12 P49069,P09601,P51648,Q13190,O43681 5 Interleukin 12 signaling 0.3821391361854284 1.076418546017204 0.2817401116680851 1.0 0.7415612373150542 26 P20700,O00170,P14174,P52907,O14979,P26038 6 Dna strand elongation 0.3695551614553926 1.0730468538088265 0.2832500945133147 1.0 0.7427328606129211 29 Q14566 1 Transcriptional activation of mitochondrial biogenesis 0.454888694555835 1.066131722337842 0.2863641014129712 1.0 0.7472643619075249 13 P48735,Q00059 2 Rhobtb2 gtpase cycle 0.4131043646643384 1.0620840716221691 0.2881975204905904 1.0 0.747704378341722 20 Q16643,Q12792,O43396,Q16543,P78371,P12814,Q9NYL9 7 Vxpx cargo targeting to cilium 0.4929381017127666 1.0604424308402345 0.2889433673633916 1.0 0.747704378341722 10 Q9UPT5,Q9NV70,Q8TAG9,Q8IYI6 4 Sphingolipid de novo biosynthesis 0.4619430232824788 1.034732509731332 0.3007938492143351 1.0 0.7625232005731142 12 O15269,Q96G23,O15121 3 Mtor signalling 0.4496411837398789 1.0334994459528877 0.3013702296677154 1.0 0.7625232005731142 13 P23588,P31946 2 Constitutive signaling by ligand responsive egfr cancer variants 0.6572817302590275 1.0326313344307836 0.3017764585650833 1.0 0.7625232005731142 4 Q16543 1 Constitutive signaling by egfrviii 0.6572817302590275 1.0326313344307836 0.3017764585650833 1.0 0.7625232005731142 4 Q16543 1 Signaling by egfr in cancer 0.6572817302590275 1.0326313344307836 0.3017764585650833 1.0 0.7625232005731142 4 Q16543 1 Signaling by erbb2 in cancer 0.6572817302590275 1.0326313344307836 0.3017764585650833 1.0 0.7625232005731142 4 Q16543 1 Signaling by erbb2 ecd mutants 0.6572817302590275 1.0326313344307836 0.3017764585650833 1.0 0.7625232005731142 4 Q16543 1 Akt phosphorylates targets in the cytosol 0.6570206081281305 1.031564405611501 0.3022762221626753 1.0 0.7625232005731142 4 P49841 1 Mitotic prophase 0.3075001579913647 1.029957851241253 0.3030297917937883 1.0 0.7630443313219037 63 P30154,P20700,Q99567,P02545,P30153,Q7Z3B4,Q08379,O60763,Q9BVL2,P42166,Q9H0U4,Q9BTX1,P12270,Q8N1F7,Q01105 15 Miro gtpase cycle 0.612678336269771 1.0276292540632213 0.3041242578126408 1.0 0.7644204317993406 5 O95140,P52306 2 The role of gtse1 in g2 m progression after g2 checkpoint 0.3274473695383218 1.021042825057922 0.3072341494933743 1.0 0.7659658504157909 51 P62191,P48556,P61289,P07900,Q15691,Q9UNM6,Q9BVA1,P28066,Q15008,P17980,O95067,Q92530,P62195,P68371,Q9UL46,P43686,Q13200,O00231 18 Assembly of the hiv virion 0.6543149159688213 1.0205145356559255 0.3074844990916436 1.0 0.7659658504157909 4 A5D8V6,Q9H9H4 2 Cd28 co stimulation 0.5060391857826572 1.017258852413334 0.3090303055841032 1.0 0.7684443427626098 8 Q13177,Q13153 2 Sema3a pak dependent axon repulsion 0.5106120758720293 1.0074739507231278 0.3137070696642845 1.0 0.7739680319249217 7 Q13177,Q13153 2 Glucagon like peptide 1 glp1 regulates insulin secretion 0.5092051125289738 1.0002287924691229 0.3171997983700758 1.0 0.7776691014521192 7 P10644,P63218,P13861 3 Synthesis of udp n acetyl glucosamine 0.7859678981607455 0.9975239117722576 0.318510273111914 1.0 0.7795119841949475 3 Q16222 1 Fceri mediated mapk activation 0.5008432646834926 0.9898911160926456 0.3222273422427584 1.0 0.784451352287791 8 Q13153 1 Clec7a dectin 1 induces nfat activation 0.7794902193242448 0.9876171923118948 0.3233401631293762 1.0 0.784451352287791 2 O43865 1 Transport of small molecules 0.2801996371825779 0.9808659241849748 0.326658863406124 1.0 0.7897851718576884 155 P12235,Q9UNM6,P21796,P61421,P30519,Q9C0H2,Q8TB61,P48556,P45880,P43686,P35613,P09601,P63218,P28066,Q8N4V1,O75477,O00231,O94905,Q8WWC4,Q9UBX3,P61289,Q99576,Q93050,Q92530 24 Rhou gtpase cycle 0.4015743163227026 0.978548112192129 0.3278033078893201 1.0 0.7897851718576884 20 Q13813,O43396,Q13153,Q13177,Q01082 5 Hsf1 dependent transactivation 0.4281850379569435 0.9761647741206684 0.3289828164577866 1.0 0.7912603947562281 14 P07900,Q15185,Q02790,O75190,P08238 5 Biological oxidations 0.3391273612659627 0.9693292674607702 0.3323809310773391 1.0 0.7951406805912572 41 O00170,O43169,Q9NUJ1,P07099,Q8TB61 5 Mapk family signaling cascades 0.2983995390154685 0.953456971970668 0.3403585872414205 1.0 0.8088589935294406 92 P30154,Q13813,P62191,P48556,P61289,P30153,Q9UNM6,Q14168,Q13153,P28066,Q92530,P62195,P31946,O60725,Q13177,P43686,Q05397,O00231 18 Cell extracellular matrix interactions 0.4933730165175257 0.950629435784535 0.3417925205186938 1.0 0.8104445624841043 8 P12814,Q96AC1 2 Fceri mediated nf kb activation 0.3305682962931773 0.9498392382109768 0.3421939448314925 1.0 0.8104445624841043 46 P48556,P61289,P49427,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 9 G alpha i signalling events 0.3783210473751394 0.94439611095797 0.3449672680912781 1.0 0.8117891286332531 24 P30154,P63096,P08754,P30153,P17612,Q9NRV9,Q08209,O43865,P63218,P13861,P10644,P04083 12 Interferon alpha beta signaling 0.4897851676039832 0.9318149024538168 0.3514321917094958 1.0 0.8173583220516684 8 P10321,P04439 2 Estrogen dependent gene expression 0.3385241811007274 0.921750349386179 0.3566588111341966 1.0 0.8177210583532069 32 P52655,Q13547,P07900,Q9HCL2,Q15185,Q13951,Q8WVM7,P19388,Q8N3U4,O15514,Q9UQE7 11 Cd209 dc sign signaling 0.5399742301230184 0.9155206774815202 0.3599183523668112 1.0 0.8194137283606729 6 Q13153 1 Pp2a mediated dephosphorylation of key metabolic factors 0.7625684812528355 0.9116407871867196 0.3619578439341238 1.0 0.8194137283606729 3 P30154 1 Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 0.3194773765226714 0.90971185062511 0.3629744927958063 1.0 0.8194137283606729 50 P62191,P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,Q16763,O00231 10 Factors involved in megakaryocyte development and platelet production 0.319431455644147 0.9092136801098962 0.363237344445446 1.0 0.8194137283606729 50 Q8IWA4,Q13547,P17612,P68371,O95140,O00139,Q07866,Q9NRW7,Q9H4M9,P47755,P24941,Q9Y496,Q9BVA1,P10644,Q9H0B6,P13861,P52907,Q86Y91,P45973,P33176,O95235 21 Foxo mediated transcription 0.4404607225115147 0.9063109853774326 0.3647712726250738 1.0 0.8194137283606729 12 P27348,P63104,P61981,P31946 4 Ub specific processing proteases 0.2991410869767085 0.9025782803800564 0.3667497581505921 1.0 0.8211676600181191 77 P48556,Q15388,P61289,Q9UNM6,P28066,Q92530,P62195,P21796,P45880,P43686,O00231 11 Metabolism of nucleotides 0.3224718057115439 0.9006524141706543 0.3677731570548097 1.0 0.8211676600181191 48 Q9Y3D8,Q9H0P0,P00813,Q9H773 4 Mastl facilitates mitotic progression 0.5344978052248008 0.8902407524813569 0.3733366267229285 1.0 0.8274648770609035 6 P30154 1 Downstream signaling events of b cell receptor bcr 0.3276348302185631 0.8895755949406874 0.3736938154468596 1.0 0.8274648770609035 44 P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 8 Fceri mediated ca 2 mobilization 0.620753614507215 0.8845020709758161 0.3764252449820482 1.0 0.8274909599253689 4 O43865 1 Antigen processing cross presentation 0.3150354838058039 0.884045758043817 0.3766715122240927 1.0 0.8274909599253689 51 P62191,P48556,P61289,Q9UNM6,P28066,Q12846,P17980,Q92530,P62195,P43686,P04439,P30101,O00231 13 Membrane trafficking 0.323940960985571 0.8715900895698685 0.3834320391113743 1.0 0.831545752786707 258 O60749,P49257,Q15436,A5D8V6,O60499,Q9P2W9,P31751,P54920,Q12846,Q13190,Q9H0U4,P31946,Q9H3P7,Q9H9H4,Q01082,Q8TD16,Q9NZ43,Q5VIR6,Q07866,Q96MW5,P27348,P63104,Q9UNF0,Q9NRW7,Q99627,Q14789,Q14C86,Q10567,Q04917,P55327,P47755,O60763,Q9Y6G9,Q08379,Q9H9E3,Q9Y5X3,P83436,P46459,Q9Y496,O95721,Q14203,P61981,O95249,Q9BT78,O15260,O43752,P09497,Q9H0B6,Q5VZE5,O75935,P62258,O75351,Q13813,Q9NVZ3,P42566,Q15276,Q96PC5,O00291,Q13561,Q9NV70,P52907,Q5JRA6,Q86Y91,Q9UPT5,Q9HCU5,P33176,P61201 67 Synthesis of dna 0.2930268651232926 0.8481007712697822 0.3963818521375062 1.0 0.8451675539252327 87 P62191,Q14566,P48556,P61289,P40937,P43686,Q9UNM6,P28066,Q9BRT9,Q92530,P62195,O00231,P49643,Q16763,P49005,O43913 16 Regulation of plk1 activity at g2 m transition 0.3267718745369147 0.8474560587153767 0.3967409694415758 1.0 0.8451675539252327 41 Q15154,P41208,P07900,P17612,P30153,O75935,Q15691,Q96CS2,Q14203,P61981,Q13561,O94927,P68371,O95067,P62258,Q9H6D7 16 Signaling by fgfr2 0.3711195889170789 0.8473183793740697 0.3968176849178926 1.0 0.8451675539252327 23 O15514,P30153 2 Signaling by fgfr 0.3711195889170789 0.8473183793740697 0.3968176849178926 1.0 0.8451675539252327 23 O15514,P30153 2 Unfolded protein response upr 0.3256820436852903 0.8464373811195652 0.397308792499458 1.0 0.8451675539252327 42 Q969H8,P02545,Q9NWM8,Q96B26,Q9Y4L1,Q14999,Q14203,P43307,P61421,Q9HCU5 10 Runx1 regulates estrogen receptor mediated transcription 0.7430349733254307 0.8462006855839405 0.3974407995519367 1.0 0.8451675539252327 2 Q9HCL2 1 Runx1 regulates transcription of genes involved in differentiation of myeloid cells 0.7430349733254304 0.8462006855839392 0.3974407995519373 1.0 0.8451675539252327 2 P17931 1 Runx2 regulates genes involved in cell migration 0.7430349733254304 0.8462006855839392 0.3974407995519373 1.0 0.8451675539252327 2 P31751 1 Protein ubiquitination 0.3501162161669775 0.8403671013978123 0.400702589047885 1.0 0.8488915972255774 27 Q5VTR2,P50542,P60604,P04439,Q96BN8 5 Pyruvate metabolism 0.3945587025571082 0.8398052175242796 0.4010176075782476 1.0 0.8488915972255774 16 P21796 1 G2 m dna replication checkpoint 0.6063182535728373 0.8267970983940209 0.4083520749454861 1.0 0.8543988950616681 4 Q99640 1 Constitutive signaling by overexpressed erbb2 0.7388685169846437 0.8259705903471986 0.4088207750661852 1.0 0.8543988950616681 3 Q16543 1 Signaling by fgfr1 0.5198584764997641 0.8230660520388952 0.4104704326665975 1.0 0.8543988950616681 6 P27361,P19174,P30153 3 Signaling by fgfr3 0.5198584764997641 0.8230660520388952 0.4104704326665975 1.0 0.8543988950616681 6 P27361,P19174,P30153 3 Signaling by fgfr4 0.5198584764997641 0.8230660520388952 0.4104704326665975 1.0 0.8543988950616681 6 P27361,P19174,P30153 3 Glycogen metabolism 0.4358160585193135 0.8172107745955401 0.4138079861641945 1.0 0.8564720188413225 11 Q16851,P46020,Q96G03 3 Protein protein interactions at synapses 0.3970376036487884 0.8152279458501616 0.4149418442527417 1.0 0.8575464781223329 15 O95197,Q13136,Q14254 3 Transcription of the hiv genome 0.3261456948468691 0.8086642501085884 0.4187082969230271 1.0 0.8623403969531346 32 O15514 1 Glucagon signaling in metabolic regulation 0.5165450295283306 0.8079558855826354 0.4191159778739965 1.0 0.8623403969531346 6 P10644,P63218,P13861 3 Vasopressin regulates renal water homeostasis via aquaporins 0.5165450295283306 0.8079558855826354 0.4191159778739965 1.0 0.8623403969531346 6 P10644,P63218,P13861 3 Cyclin a b1 b2 associated events during g2 m transition 0.4236429062865791 0.8068819470401746 0.4197345006574722 1.0 0.8623411316895048 12 P30154,O95067,Q99640,P30153 4 Beta oxidation of lauroyl coa to decanoyl coa coa 0.6005674701562427 0.8039812907988267 0.4214077801677409 1.0 0.8632362016651962 4 P30084 1 Beta oxidation of hexanoyl coa to butanoyl coa 0.6005674701562427 0.8039812907988267 0.4214077801677409 1.0 0.8632362016651962 4 P30084 1 Glycerophospholipid biosynthesis 0.3374108008121634 0.7949606634696834 0.4266363844907079 1.0 0.8695256711322176 29 Q9NPH0,Q9C0D9 2 Dag and ip3 signaling 0.4631501892129189 0.793343158646931 0.4275779180445371 1.0 0.8695256711322176 8 O43865,P13861,P10644 3 Suppression of apoptosis 0.5972716488730698 0.7909546318486774 0.4289704663697939 1.0 0.8695256711322176 4 P27361,P23246,P49840 3 Negative feedback regulation of mapk pathway 0.5972716488730663 0.7909546318486638 0.4289704663698019 1.0 0.8695256711322176 4 P27361,P36507,Q02750 3 Hiv infection 0.262810362238296 0.7901080817326991 0.4294646504731885 1.0 0.8695256711322176 143 P12235,Q99567,A5D8V6,Q9UNM6,Q7Z3B4,O15514,P17980,P57740,Q9H9H4,P04439,Q9UI12,P48556,P52655,Q8IXH7,Q10567,Q9BVL2,P43686,P23193,Q92804,P28066,Q9BTX1,Q93034,Q13177,Q8N1F7,O00231,P62191,O75351,O43633,P61289,Q92530,P62195,P12270 32 The canonical retinoid cycle in rods twilight vision 0.727326615293421 0.7866756196785155 0.4314717796084637 1.0 0.8698869027528808 2 P09455 1 Interleukin 4 and interleukin 13 signaling 0.4196349754465719 0.7833914969554584 0.4333972478720236 1.0 0.8724230314306969 12 P08670 1 Neddylation 0.2895295012550276 0.7801140977599856 0.4353237190706742 1.0 0.875038311388459 80 P62191,P48556,P61289,Q99627,Q9UNM6,Q14999,Q9NX08,P28066,Q9BTE7,P17980,Q92530,Q9BT78,P62195,Q93034,Q8N668,P43686,O00231,P61201 18 Interaction between l1 and ankyrins 0.7245929677874103 0.7751690262718146 0.4382397880424791 1.0 0.8783685406885896 3 Q13813 1 Visual phototransduction 0.4593067629750271 0.7735867430193265 0.4391752142205498 1.0 0.8789805220052612 8 Q6NUM9,P49354,P09455 3 Rna polymerase iii transcription initiation from type 3 promoter 0.5074117708474435 0.7665159604266476 0.4433693588768483 1.0 0.8832686041992946 6 O15160 1 Rna polymerase iii chain elongation 0.5074117708474435 0.7665159604266476 0.4433693588768483 1.0 0.8832686041992946 6 O15160 1 Transcriptional regulation by tp53 0.2548718538572438 0.7656321815649835 0.4438951903497297 1.0 0.8832686041992946 125 P30154,P00403,Q9HAF1,P13073,O15514,O60921,P31946,P27348,P63104,P40937,P30153,Q8IXH7,Q04917,P61981,Q92804,P20674,P62258,O75880,O75175 19 Signaling by the b cell receptor bcr 0.3110030884562688 0.7639066531199383 0.4449228723835092 1.0 0.8832686041992946 47 P62191,P48556,P61289,O43865,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 10 Josephin domain dubs 0.7190278601066993 0.7556480657229714 0.4498602294618243 1.0 0.8870554238552298 2 P54727 1 Rho gtpases activate cit 0.4248355303668362 0.7550741821914334 0.4502044731824393 1.0 0.8870554238552298 11 P60660 1 Rna polymerase ii transcribes snrna genes 0.319889595620524 0.7522934812542686 0.4518745871709271 1.0 0.8878380973287934 32 O15514,Q6P9B9,P52655,Q9NP77 4 Signaling by alk in cancer 0.3196151349372009 0.7493097706050279 0.4536705201546418 1.0 0.8888628871007378 35 Q07866,O00291,Q14203,P10644,P12270,P67936,P06753,P33176,P26038 9 Separation of sister chromatids 0.2695499829496195 0.7355864185889753 0.4619824303349369 1.0 0.8914882304395528 111 P30154,Q92674,Q15005,O43237,Q9UNM6,P17980,Q9UQE7,Q9BS16,P48556,P30153,Q8NBT2,Q9Y6G9,P43686,P28066,O14777,O00231,Q16763,P62191,P61289,Q8WVM7,Q96EA4,Q92530,P62195,Q96BD8 24 Rhoc gtpase cycle 0.3178324940762161 0.7348389545200981 0.4624375798753224 1.0 0.8914882304395528 36 P49257,Q14254,Q13190,Q07021,Q13464 5 Deactivation of the beta catenin transactivating complex 0.4445857175969237 0.726242015254736 0.4676904191879716 1.0 0.8914882304395528 9 P63104,Q13547,Q9UBL3,P31751 4 Vegfr2 mediated cell proliferation 0.5805796607099211 0.7255954573510885 0.4680868067371677 1.0 0.8914882304395528 4 P20936,O43865 2 Negative regulation of fgfr1 signaling 0.5411561184522473 0.7239199878869411 0.4691148580866975 1.0 0.8914882304395528 5 P30153 1 Negative regulation of fgfr2 signaling 0.5411561184522473 0.7239199878869411 0.4691148580866975 1.0 0.8914882304395528 5 P30153 1 Negative regulation of fgfr3 signaling 0.5411561184522473 0.7239199878869411 0.4691148580866975 1.0 0.8914882304395528 5 P30153 1 Spry regulation of fgf signaling 0.5411561184522473 0.7239199878869411 0.4691148580866975 1.0 0.8914882304395528 5 P30153 1 Negative regulation of fgfr4 signaling 0.5411561184522473 0.7239199878869411 0.4691148580866975 1.0 0.8914882304395528 5 P30153 1 Cd28 dependent vav1 pathway 0.4966840585314429 0.7182879403136659 0.4725797644725358 1.0 0.8945030820070387 6 Q13153 1 Interleukin 12 family signaling 0.3272049123322363 0.7089532555412295 0.4783534850959416 1.0 0.9005440104032911 29 P20700,O00170,P14174,P52907,O14979,P26038 6 Circadian clock 0.4285721369112643 0.7055631472831205 0.4804598489767979 1.0 0.903290416876864 10 P43490,P50416 2 Formation of rna pol ii elongation complex 0.3137879687015729 0.6964224485000728 0.4861643086126856 1.0 0.9080078586175454 33 O15514 1 Robo receptors bind akap5 0.7017129508038749 0.6952885878334019 0.4868744646924186 1.0 0.9080078586175454 3 P13861 1 Mapk3 erk1 activation 0.5708079645914582 0.6878715116567268 0.4915336979710605 1.0 0.9123470143048188 4 P27361,P06493 2 Rho gtpases activate ktn1 0.4423035406277335 0.6871064844542804 0.492015628255366 1.0 0.9123470143048188 8 Q07866,P33176,Q86UP2 3 Transferrin endocytosis and recycling 0.412090041364326 0.6838946976109834 0.4940416625250563 1.0 0.9128319459900048 11 Q9UI12,Q9Y5K8,Q93050,P61421,P36543 5 Ephrin signaling 0.488578131104499 0.682214844136753 0.4951031097107559 1.0 0.9134481708781615 6 Q13153 1 Interleukin 1 signaling 0.3012325061382083 0.6802552327651414 0.4963428651659223 1.0 0.9134481708781615 48 P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 8 Reproduction 0.3332460935174582 0.6792264649087666 0.4969943811444621 1.0 0.9134481708781615 26 P20700,P02545,Q9UH99 3 Meiosis 0.3332460935174582 0.6792264649087666 0.4969943811444621 1.0 0.9134481708781615 26 P20700,P02545,Q9UH99 3 Apc c mediated degradation of cell cycle proteins 0.2821064779404267 0.6742721704717379 0.5001382936244965 1.0 0.9142536789319232 57 P48556,P61289,Q9UNM6,P28066,Q92530,P43686,O00231 7 Adenylate cyclase inhibitory pathway 0.6955232730507079 0.6740517829340869 0.5002783925792058 1.0 0.9142536789319232 3 P63096,P08754 2 M phase 0.2913788271749488 0.6733737540543434 0.5007095417232899 1.0 0.9142536789319232 210 P30154,Q99567,Q92674,Q15005,O43237,Q9UNM6,Q7Z3B4,P17980,Q9UQE7,P42166,P57740,Q9H0U4,Q86XL3,Q9BS16,P20700,P48556,P07900,P30153,O75935,Q08379,Q8NBT2,O60763,Q9Y6G9,Q9BVL2,Q8IXJ6,P43686,P53990,Q96CS2,Q14203,P61981,P28066,Q9BTX1,Q8N1F7,Q16763,P62258,Q01105,O14777,O00231,P62191,O43633,P02545,P61289,P41208,Q8WVM7,Q96EA4,Q13561,Q92530,P62195,P12270,O94927,Q96BD8 51 Galactose catabolism 0.6950207468879677 0.6677885800647935 0.5042685572397816 1.0 0.9179735976934048 2 Q96G03 1 Signaling by vegf 0.3102847994751586 0.667080105101048 0.5047209673339366 1.0 0.9179735976934048 32 Q96JJ3,O43865,Q13153,P46108,P31751,Q13177,Q05397,Q13464 8 Clec7a dectin 1 signaling 0.2958544086083049 0.6592693649853236 0.5097228110277838 1.0 0.9193062369464132 50 P48556,P61289,P49427,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 9 Pcp ce pathway 0.2936744232995961 0.6554931935080949 0.5121502672731917 1.0 0.9193062369464132 51 P62191,P48556,P61289,Q9UNM6,P28066,Q92530,P62195,P43686,O00231 9 Glycogen synthesis 0.4816263804317181 0.6515634136671739 0.5146828561755505 1.0 0.9193062369464132 6 Q16851,Q96G03 2 Tp53 regulates transcription of dna repair genes 0.3084874430513153 0.649527164265785 0.5159976942860514 1.0 0.9193062369464132 33 O15514 1 Transport of vitamins nucleosides and related molecules 0.4385278151051649 0.6443850563381787 0.5193257724201565 1.0 0.9236634369392412 7 P12235 1 Signaling by notch 0.2745907055085126 0.6432997367194584 0.5200296270934706 1.0 0.9236634369392412 60 P62191,P63104,P48556,P61289,Q9H488,Q9UNM6,P28066,Q92530,P62195,Q9UBV2,P43686,O00231 12 G beta gamma signalling through cdc42 0.5206884577525681 0.6404029260716763 0.5219106810428202 1.0 0.9251148666515048 5 P63218 1 Transport of connexons to the plasma membrane 0.5564435129640679 0.6332588466096939 0.5265646228488707 1.0 0.9292752781567114 4 P68371 1 Gap junction assembly 0.5564435129640679 0.6332588466096939 0.5265646228488707 1.0 0.9292752781567114 4 P68371 1 Vesicle mediated transport 0.3128642420381148 0.629975008884264 0.5287109351962505 1.0 0.930077874651664 265 O60749,P49257,Q15436,A5D8V6,O60499,Q9P2W9,P31751,P54920,Q12846,Q13190,Q9H0U4,P31946,Q9H3P7,Q9H9H4,Q01082,Q8TD16,Q9NZ43,Q5VIR6,Q07866,Q96MW5,P27348,P63104,Q9UNF0,Q9NRW7,Q99627,Q14789,Q14C86,Q10567,Q04917,P55327,P47755,O60763,Q9Y6G9,Q08379,Q9H9E3,Q9Y5X3,P83436,P46459,Q9Y496,O95721,Q9Y4L1,Q14203,P61981,O95249,Q9BT78,O15260,O43752,P09497,Q9H0B6,Q5VZE5,O75935,P62258,O75351,Q13813,Q9NVZ3,P42566,Q15276,Q96PC5,O00291,Q13561,Q9NV70,P52907,Q5JRA6,Q86Y91,Q9UPT5,Q9HCU5,P33176,P61201 68 Miscellaneous transport and binding events 0.4341606689900917 0.6232498576054476 0.533120342809073 1.0 0.9354753185140336 7 P35612,Q8N4V1,Q9UNS2 3 Transcriptional regulation by runx1 0.2762491345946083 0.6206873217155553 0.5348053728068942 1.0 0.9368066885493068 70 P48556,P61289,Q9UBL3,Q9HCL2,Q9UNM6,P28066,Q92530,P43686,Q969G3,O00231 10 Aryl hydrocarbon receptor signalling 0.6792173139638465 0.6189737800253401 0.5359336321137251 1.0 0.9368066885493068 3 O00170,Q15185 2 Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol 0.6783278980136338 0.6160081291023258 0.5378891546214013 1.0 0.9368066885493068 3 P51659,P22307 2 Metabolism of folate and pterines 0.4216043582288078 0.6082482085161997 0.5430228653229692 1.0 0.938714645184936 9 Q9H2D1 1 Beta oxidation of butanoyl coa to acetyl coa 0.6759862461540613 0.6082202958557016 0.5430413753865544 1.0 0.938714645184936 3 P30084 1 Glycogen breakdown glycogenolysis 0.430628460802971 0.6062625763232641 0.5443404052898713 1.0 0.9391788843246522 7 Q96G03 1 G alpha z signalling events 0.4705725599394977 0.6034353857372585 0.5462190878851487 1.0 0.9391788843246522 6 P63218,P63096,P08754 3 Cd163 mediating an anti inflammatory response 0.676644931831655 0.6027482653799511 0.5466761677932743 1.0 0.9391788843246522 2 Q16539 1 Aquaporin mediated transport 0.4280103696801429 0.5937364939690979 0.5526883703261756 1.0 0.9425431254340036 7 P10644,P63218,P13861 3 Negative regulation of mapk pathway 0.3833685405919967 0.5762213651731894 0.5644655658055102 1.0 0.947483758642308 12 P30154,P31946 2 Cellular response to heat stress 0.268967342457266 0.5731071955059631 0.5665721155488974 1.0 0.947483758642308 61 Q99567,Q02790,Q7Z3B4,P57740,P38646,P07900,P48723,Q9UL15,Q9BVL2,P55072,O95816,P08238,O95757,Q15185,Q96EE3,O75190,Q9BTX1,Q8N1F7,Q8WUM0,P62258,P27361,Q96B36,P49841,O95817,P12270 25 Formyl peptide receptors bind formyl peptides and many other ligands 0.6652772271214809 0.5729900301719238 0.5666514444360689 1.0 0.947483758642308 3 P04083 1 Translation of sars cov 1 structural proteins 0.422650479649395 0.5682744063065142 0.5698486548393522 1.0 0.947483758642308 7 P49841 1 Signaling by braf and raf1 fusions 0.3327109767446913 0.5650129659342406 0.5720649450964004 1.0 0.9500364266779506 23 Q9NRY5,P31946 2 Gdp fucose biosynthesis 0.664789567279195 0.561962696079016 0.5741414355334529 1.0 0.9501274480532944 2 O60547 1 Formation of xylulose 5 phosphate 0.6618735582179467 0.5619309898179109 0.574163038501023 1.0 0.9501274480532944 3 P14550 1 Activation of anterior hox genes in hindbrain development during early embryogenesis 0.345761381367855 0.5596933537991021 0.5756886164453765 1.0 0.9503971833624854 17 O15514 1 Dna replication 0.268737863288854 0.5494700441715615 0.5826829167286909 1.0 0.9505738313253824 93 P62191,Q14566,P48556,P61289,P40937,P43686,Q9UNM6,P28066,Q9BRT9,Q92530,P62195,O00231,P49643,Q16763,P49005,O43913 16 Pentose phosphate pathway 0.4139903671606302 0.5475116824426441 0.5840272466554493 1.0 0.9505738313253824 8 P37837,Q96G03,P52209 3 Gene silencing by rna 0.2902713639608775 0.5460210416165376 0.5850514734357746 1.0 0.9505738313253824 46 Q99567,Q7Z3B4,Q9BVL2,Q15631,O15514,P57740,Q9BTX1,P12270,Q8N1F7 9 E3 ubiquitin ligases ubiquitinate target proteins 0.3436119819945308 0.5460084911347675 0.5850601004773361 1.0 0.9505738313253824 17 P04439,P50542 2 Mitotic prometaphase 0.263181925182816 0.5444077833460184 0.5861608909302203 1.0 0.9505738313253824 103 Q14980,Q15154,P30154,Q92674,P17612,Q15005,O43237,Q9UQE7,P57740,P68371,O95067,Q9BS16,Q9BSJ2,P07900,Q15691,P30153,O75935,Q8N3U4,Q8NBT2,Q9Y6G9,P07437,Q9HBM1,Q96EE3,Q96CS2,Q14203,P61981,Q9BVA1,Q8WUM0,O14777,P62258,Q9H6D7,P41208,Q8WVM7,Q96EA4,Q13561,Q9Y266,O94927,Q96BD8 38 Runx2 regulates osteoblast differentiation 0.5261256597790257 0.5219746129601858 0.6016880066604546 1.0 0.9505738313253824 4 P27361,Q13951 2 Nuclear envelope breakdown 0.291786848092041 0.5185477182111886 0.6040761757007287 1.0 0.9505738313253824 41 P20700,Q99567,P02545,Q7Z3B4,Q9BVL2,P42166,P57740,Q9BTX1,P12270,O95067,Q8N1F7,P50402 12 Fructose metabolism 0.6478684366929359 0.5171787722102533 0.6050313690693208 1.0 0.9505738313253824 3 Q3LXA3 1 Rho gtpases activate paks 0.3630545988826432 0.5142631853446076 0.6070679969674615 1.0 0.9505738313253824 13 Q13177,P60660,Q13153 3 Transcriptional regulation by e2f6 0.4064654745580279 0.5116102745305605 0.6089237932084255 1.0 0.9505738313253824 8 Q13185,Q9UBK9 2 Phospholipid metabolism 0.2894771518995668 0.5107741020071168 0.6095092455949684 1.0 0.9505738313253824 43 Q9NPH0,Q9C0D9,Q9HCL2 3 Sema4d in semaphorin signaling 0.4018709968916042 0.510407171428111 0.6097662337298866 1.0 0.9505738313253824 9 Q13464 1 Beta catenin independent wnt signaling 0.2671126184031447 0.5092857825816923 0.6105519220158611 1.0 0.9505738313253824 57 P62191,P48556,P61289,Q9UNM6,P63218,P28066,Q92530,P62195,P43686,O00231 10 G protein beta gamma signalling 0.4095293306235438 0.5070761733168602 0.6121013723423112 1.0 0.9505738313253824 7 P63218,Q13153 2 Hcmv late events 0.2918117975808289 0.5069969526901327 0.6121569567270861 1.0 0.9505738313253824 38 Q99567,O43633,Q9HD42,Q9NZ09,A5D8V6,Q7Z3B4,Q9BVL2,P57740,Q9H9H4,Q9UQN3,Q9BTX1,Q8N1F7,Q9BRG1,P12270,Q8WUM0 15 Glycolysis 0.2835393078697865 0.5065013876919092 0.6125047157584134 1.0 0.9505738313253824 48 P30154,Q99567,P17612,Q7Z3B4,P57740,P08237,P52789,P30153,Q9BVL2,P00558,A6NDG6,Q96EE3,Q9BTX1,Q8WUM0,Q8N1F7,P46926,P18669,Q9BRR6,P12270 19 Vegfr2 mediated vascular permeability 0.3784735082676175 0.5030501773269492 0.6149289943258369 1.0 0.9505738313253824 11 Q13177,Q13153,P31751 3 Signaling by nuclear receptors 0.2631859794203726 0.5028780778346773 0.61504999485788 1.0 0.9505738313253824 62 Q13547,P04899,P19388,P50416,P31751,O15514,Q9UQE7,Q13451,Q8TC12,Q05397,P52655,P07900,Q9HCL2,Q8N3U4,Q99873,P08754,Q15185,P63218,P27361,Q13951,P63096,Q8WVM7,Q08752 23 Synthesis of bile acids and bile salts 0.4851269388579411 0.5013606020482888 0.616117361942421 1.0 0.9505738313253824 5 P22307,P51659,O14734 3 Bile acid and bile salt metabolism 0.4851269388579411 0.5013606020482888 0.616117361942421 1.0 0.9505738313253824 5 P22307,P51659,O14734 3 Signaling by wnt in cancer 0.3989701670263849 0.4963597508942269 0.6196406168626007 1.0 0.9505738313253824 9 P30154,P49841 2 Extracellular matrix organization 0.2938737218349774 0.4949443312939868 0.6206394167192253 1.0 0.9505738313253824 31 P07384,P35613,O75718,P12814,O15460 5 Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10 0.640675956122165 0.4946947948898362 0.6208155762938663 1.0 0.9505738313253824 3 Q7Z434,Q14258 2 Ikk complex recruitment mediated by rip1 0.6406759561221627 0.494694794889828 0.6208155762938721 1.0 0.9505738313253824 3 P61088,Q6SZW1 2 Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1 0.6407824540604634 0.4826012277979868 0.6293789071652367 1.0 0.9574350568826392 2 Q13547 1 Estrogen dependent nuclear events downstream of esr membrane signaling 0.4801241001608678 0.4825644833201484 0.6294050024201194 1.0 0.9574350568826392 5 Q05397,P31751 2 Processing of smdt1 0.3743892654949072 0.4819606009064447 0.6298339349165698 1.0 0.9574350568826392 11 Q10713,Q9UJZ1,Q96TA2,Q99623,Q8WWC4 5 Ticam1 rip1 mediated ikk complex recruitment 0.640486069946652 0.481650792785996 0.6300540374324464 1.0 0.9574350568826392 2 P61088 1 Signaling by wnt 0.2645571039132916 0.4770900763270682 0.6332979808776753 1.0 0.9581402028492836 88 P30154,P62191,P48556,P61289,P63104,Q9UBL3,P30153,Q9UNM6,P63218,P28066,Q92530,P62195,P49841,Q96QK1,P43686,P09497,O00231 17 Deubiquitination 0.2617114886169286 0.4733111781742012 0.6359911883220755 1.0 0.9581402028492836 96 P48556,Q15388,P61289,Q9Y4E8,Q7Z434,Q9UNM6,P28066,P54727,Q92530,P62195,P21796,P45880,P43686,O00231 14 G alpha s signalling events 0.439243315283946 0.4720370116611387 0.6369003707123366 1.0 0.9581402028492836 6 P63218,P63096,P08754 3 Regulation of hsf1 mediated heat shock response 0.2698749145643926 0.4709751509852627 0.6376584800508716 1.0 0.9581402028492836 54 Q99567,Q9UL15,Q7Z3B4,Q9BVL2,P49841,O95817,Q9BTX1,P12270,O95816,Q8N1F7,P62258 11 Gaba b receptor activation 0.4763625988314615 0.4685750925738573 0.6393733842233198 1.0 0.9581402028492836 5 P63218,P63096,P08754 3 Gaba receptor activation 0.4763625988314615 0.4685750925738573 0.6393733842233198 1.0 0.9581402028492836 5 P63218,P63096,P08754 3 Adp signalling through p2y purinoceptor 12 0.4763625988314615 0.4685750925738573 0.6393733842233198 1.0 0.9581402028492836 5 P63218,P63096,P08754 3 Raf independent mapk1 3 activation 0.4008333377958418 0.4675117143932606 0.6401338129430338 1.0 0.9581402028492836 7 P27361,P36507,P06493,Q02750 4 Plasma lipoprotein assembly 0.6303556742791493 0.4630686189492088 0.6433151826798571 1.0 0.9608401283066388 3 P17612 1 Response to elevated platelet cytosolic ca2 0.2864003867062629 0.4589438313809207 0.6462745018717722 1.0 0.9615567740008945 35 Q12846,Q15833,P12814,O43852,Q9Y6I9 5 Viral messenger rna synthesis 0.286071951232905 0.4562422880455948 0.6482157592925755 1.0 0.9619797704395135 35 Q99567,Q7Z3B4,Q9BVL2,O15514,Q9BTX1,P12270,Q8N1F7 7 Interleukin 1 family signaling 0.2735216431379658 0.453911895319849 0.6498922415327031 1.0 0.9626997091362256 51 P48556,P61289,Q9UNM6,P28066,Q92530,P43686,O00231 7 Rna polymerase iii transcription 0.3605487698088102 0.4530737046587633 0.6504956693086619 1.0 0.9626997091362256 12 O15160,P05455 2 Ca dependent events 0.3959756992360225 0.4457941585641551 0.6557459417378981 1.0 0.9642106563376798 7 P10644,P13861 2 Signaling by rho gtpases miro gtpases and rhobtb3 0.3045370371423063 0.4396968467685967 0.6601566866816757 1.0 0.9651169463214008 273 Q5VTR2,P30154,Q07065,Q14254,Q92674,P49257,Q9BXS4,Q15005,Q13190,P42166,Q86XL3,P31946,Q07021,P31948,Q9NYL9,P30519,Q05397,Q01082,P06753,Q9BS16,O95140,Q07866,P27348,P20700,P63104,Q13505,P30153,O43396,Q04917,Q13153,Q8NBT2,Q9Y6G9,Q96AC1,Q96HY6,P78371,P52306,P67936,Q13464,P08670,P12277,Q16643,P35580,P60660,P61981,Q9BT78,Q9H0B6,Q13177,Q9P0I2,Q03001,P62258,O43663,Q8NBN3,O14777,Q13813,O60879,Q12792,Q96CS3,Q68EM7,Q16718,Q96EA4,O15173,Q86UP2,Q16543,P12814,Q96BD8,P33176,P61201 67 Rac3 gtpase cycle 0.2826967716668789 0.428722972777651 0.6681248403743969 1.0 0.968850470189484 35 P49257,Q13153,O15173,P42166,Q96AC1,Q13177 6 Semaphorin interactions 0.3121284802261657 0.4241040369456812 0.6714899415195723 1.0 0.9711246739378974 23 Q13177,P60660,Q13464,Q13153 4 P130cas linkage to mapk signaling for integrins 0.616668008542994 0.4223586989035838 0.67276321917267 1.0 0.9711246739378974 3 Q05397 1 Oncogenic mapk signaling 0.2944835293671393 0.4069737253768304 0.6840272860326029 1.0 0.9806647278079352 27 Q9NRY5,P31946 2 Regulation of ifna signaling 0.6104212932984503 0.4042774623398583 0.6860086967747208 1.0 0.9806647278079352 3 P42224 1 Regulation of ifng signaling 0.6104212932984503 0.4042774623398583 0.6860086967747208 1.0 0.9806647278079352 3 P42224 1 Rnd2 gtpase cycle 0.3341558517080061 0.4041344995000314 0.6861138167315732 1.0 0.9806647278079352 14 O43396,Q86UP2,Q07065,Q03001 4 G2 m dna damage checkpoint 0.2791022574419023 0.4004558063487981 0.6888208276577064 1.0 0.9815169096859044 38 P27348,P63104,Q04917,P61981,O60921,P31946,P62258 7 Rnd1 gtpase cycle 0.3330257923152848 0.3979625102795421 0.6906578206864153 1.0 0.9831302651607648 14 Q9BXS4,Q14254,O43396,P31948,Q03001 5 Nef mediated downregulation of mhc class i complex cell surface expression 0.4530535910741462 0.3848969014019582 0.7003138017101893 1.0 0.990512334847312 5 P04439,Q10567 2 Signaling by fgfr in disease 0.3128456185111184 0.3751338915128073 0.707560892672515 1.0 0.9962589994223694 20 O15514 1 Antigen presentation folding assembly and peptide loading of class i mhc 0.3287291998587929 0.3747362895912772 0.7078566004676734 1.0 0.9962589994223694 14 P10321,Q9NZ08,Q15436,P04439,P30101 5 Cholesterol biosynthesis 0.3147890368397586 0.3739374623505906 0.708450844033685 1.0 0.9962589994223694 18 Q9H2C2,Q15392,Q15800,P14324 4 Activation of the ap 1 family of transcription factors 0.5970945745627096 0.3668135874051322 0.7137580717916463 1.0 1.0 3 Q16539,P27361 2 Cytokine signaling in immune system 0.2552762688704422 0.3662476653770199 0.7141802774743033 1.0 1.0 175 P30154,Q99567,P46934,Q9UNM6,Q7Z3B4,P31751,P46108,Q12846,P17980,P57740,P04439,P26038,P10321,P20700,P48556,P63104,P30153,Q9BVL2,O14979,P43686,P08670,O00170,P14174,P09601,P28066,Q15833,Q9BTX1,Q93034,Q13177,Q8N1F7,O00231,Q13277,P62191,P61289,P52907,Q92530,P62195,P12270,P37837 39 Platelet aggregation plug formation 0.4116116785411458 0.3641071569601206 0.715777992644294 1.0 1.0 6 Q05397 1 Integrin signaling 0.4116116785411458 0.3641071569601206 0.715777992644294 1.0 1.0 6 Q05397 1 Dissolution of fibrin clot 0.5959086866291168 0.363555871890244 0.7161896840257367 1.0 1.0 3 P35237,P60903 2 Signaling by activin 0.5969176052163616 0.3508835270565812 0.7256757302480481 1.0 1.0 2 P27361 1 Signaling by nodal 0.5969176052163616 0.3508835270565812 0.7256757302480481 1.0 1.0 2 P27361 1 Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects 0.4744958481613064 0.349197721458385 0.7269408766819505 1.0 1.0 4 Q00534,P24941,P06400 3 Oncogene induced senescence 0.3710299792223211 0.3392570763914184 0.7344160752367221 1.0 1.0 7 P27361,Q00534,P06400,P11802,P28482,P04637 6 Tristetraprolin ttp zfp36 binds and destabilizes mrna 0.3217977573399615 0.3381114153352687 0.7352792284238965 1.0 1.0 14 P31946 1 Host interactions of hiv factors 0.25047541210912 0.3323629350517012 0.7396152227898389 1.0 1.0 96 P12235,Q99567,Q9UNM6,Q7Z3B4,P17980,P04439,Q9UI12,P48556,Q10567,Q9BVL2,P43686,P28066,Q9BTX1,Q93034,Q13177,Q8N1F7,O00231,P62191,P61289,Q92530,P62195,P12270 22 G alpha 12 13 signalling events 0.3529244112419726 0.3285687759851819 0.7424816519746527 1.0 1.0 10 Q13464 1 Phase ii conjugation of compounds 0.2806290631081555 0.3277320648606072 0.743114256934402 1.0 1.0 28 Q16851,Q99707,P14550,P21964,Q9NUJ1,Q99735,O43708,Q8WUX2,Q8TB61 9 Butyrate response factor 1 brf1 binds and destabilizes mrna 0.3276387058880036 0.3265337708934088 0.7440205427727571 1.0 1.0 13 P31946 1 Sumo is conjugated to e1 uba2 sae1 0.5856550088915247 0.3202667747092184 0.748766107670755 1.0 1.0 2 Q9UBE0 1 Sumo is transferred from e1 to e2 ube2i ubc9 0.5856550088915247 0.3202667747092184 0.748766107670755 1.0 1.0 2 Q9UBE0 1 Map2k and mapk activation 0.3373615990765551 0.3029043664512595 0.7619627436433831 1.0 1.0 11 P36507,P18206,P31946 3 Recycling of eif2 gdp 0.3609638922166116 0.2989683331170619 0.7649642076300653 1.0 1.0 7 P49770 1 Hcmv infection 0.2506212790942699 0.2900903179920778 0.7717471426112932 1.0 1.0 54 Q99567,A5D8V6,O43237,Q7Z3B4,P57740,P68371,Q9H9H4,Q9NZ09,Q9BVL2,Q9Y6G9,P83916,Q9UQN3,Q9BTX1,Q8N1F7,Q8WUM0,O43633,Q9HD42,Q9BRG1,P12270 19 Pyroptosis 0.3586582843424717 0.2899846403776549 0.7718279881871088 1.0 1.0 7 O43633,Q9UQN3 2 Tysnd1 cleaves peroxisomal proteins 0.4218723843003573 0.2824432358644284 0.7776036664765569 1.0 1.0 5 Q15067,O00116,P22307 3 Antigen processing ubiquitination proteasome degradation 0.2464732440245303 0.2815045305059857 0.7783234536859736 1.0 1.0 95 P46934,Q9UNM6,P60604,P48556,P49427,Q14999,Q9UNE7,P43686,O94874,Q9BSL1,P28066,Q6UWE0,Q93034,Q92990,O00231,P62191,P61289,Q92530,P62195 19 Wnt mediated activation of dvl 0.5693538826318925 0.2785296402290552 0.7806058152487807 1.0 1.0 2 P67870 1 Signaling by moderate kinase activity braf mutants 0.3249908381094303 0.2785238826248051 0.780610234372966 1.0 1.0 12 P36507,P18206,P31946 3 Signaling by receptor tyrosine kinases 0.2279245864208698 0.2708190964756101 0.7865301716898245 1.0 1.0 122 P30154,Q13547,P46934,P31751,P46108,Q9Y487,O15514,P31946,P61421,Q05397,P50570,P16949,Q9UI12,P07900,P30153,Q13153,Q14155,Q9Y5K8,Q9UNE7,Q13464,O43865,P31943,Q93034,Q13177,P36543,P36507,P42566,Q96JJ3,Q13043,Q93050,Q16543,O60610,P61201 33 Ddx58 ifih1 mediated induction of interferon alpha beta 0.2962574503684244 0.2680565385323054 0.788655799131101 1.0 1.0 17 P07900,Q86UT6,Q7Z434,Q14258,P09429,O94826,Q3LXA3,Q9UII4 8 Mhc class ii antigen presentation 0.2441586610060266 0.2495626379518609 0.8029255950340795 1.0 1.0 55 Q07866,Q9Y496,O75935,Q15436,O43237,Q10567,Q14203,P47755,Q13561,Q9Y6G9,P52907,Q9BXS5,P68371,Q99538,Q9H0B6,P33176 16 Syndecan interactions 0.4072719026263597 0.2388401711928387 0.8112295193886192 1.0 1.0 5 P12814 1 Regulation of tnfr1 signaling 0.3741336557488145 0.2337337053888305 0.8151917193006877 1.0 1.0 6 Q96BN8 1 Slc mediated transmembrane transport 0.2859667204283641 0.2298210566552377 0.8182308217858918 1.0 1.0 21 P35613,P12235,Q8TB61 3 Triglyceride metabolism 0.3423519493271545 0.2292543096235934 0.8186712634090529 1.0 1.0 7 O60664,Q9HCL2 2 Hemostasis 0.2212280826054369 0.2265647067710435 0.8207622385544109 1.0 1.0 130 P30154,Q12846,Q07021,O95140,O43852,Q05397,O43707,Q07866,P63104,Q9NRW7,P30153,Q9H4M9,P47755,Q92520,Q9Y6I9,P35613,P14174,P08754,Q9Y496,P63218,P10644,Q15833,P52907,Q86Y91,P12814,P45973,P33176 27 Prolonged erk activation events 0.3399120815376877 0.2206125802943692 0.8253941047411546 1.0 1.0 7 P31946,P46108 2 Trna modification in the mitochondrion 0.3697703776941128 0.219976848309528 0.8258891854600741 1.0 1.0 6 O75648,Q969Y2 2 Cyclin d associated events in g1 0.3269871076750462 0.2199308198197788 0.825925033157962 1.0 1.0 10 P30154 1 Regulation of insulin secretion 0.296976107776928 0.2167867379986434 0.8283745477413766 1.0 1.0 14 P63096,P17612,O43865,P63218,P13861,P10644 6 Pecam1 interactions 0.5417901600474229 0.2153252601678718 0.8295137367368752 1.0 1.0 2 P19174 1 Metabolism of cofactors 0.3676573895109424 0.2134314156325875 0.8309904788367946 1.0 1.0 6 O75874,P07900,O75208 3 Activation of ampk downstream of nmdars 0.3646884272997127 0.2043651052667956 0.8380681966732777 1.0 1.0 6 Q13885,Q9BVA1,Q9BUF5,P68371,P54619 5 Cytochrome p450 arranged by substrate type 0.5294318462676135 0.2033942299333923 0.8388269094029162 1.0 1.0 3 Q16850 1 Slc transporter disorders 0.2501102277944093 0.2000788456981835 0.8414189175395979 1.0 1.0 32 P35613,Q99567,Q7Z3B4,Q9BVL2,Q9BTX1,P12270,Q8N1F7 7 Synaptic adhesion like molecules 0.3631279167960453 0.1996616989380132 0.8417451703850372 1.0 1.0 6 Q14254 1 Class i mhc mediated antigen processing presentation 0.2278899337724441 0.1967191676291357 0.844047309583956 1.0 1.0 116 Q9NZ08,Q15436,P46934,Q9UNM6,Q12846,P17980,P60604,P04439,P48556,P49427,Q14999,Q9UNE7,P43686,O94874,Q9BSL1,P28066,Q6UWE0,Q93034,Q92990,Q16763,O00231,P62191,P61289,Q92530,P62195,P30101 26 Eph ephrin signaling 0.2512698858361203 0.1966273395663682 0.8441191743718985 1.0 1.0 36 P60660,Q13153,P09497,Q13177,Q05397,Q13464 6 Degradation of cysteine and homocysteine 0.3906073929924669 0.1928971903286273 0.8470394855038612 1.0 1.0 5 Q9UBX3 1 Maturation of sars cov 2 nucleoprotein 0.3607191175663705 0.1924862548233794 0.8473613336605517 1.0 1.0 6 P49841,Q96SB4 2 Inhibition of replication initiation of damaged dna by rb1 e2f1 0.3310349590211715 0.1902096065253794 0.8491448836257349 1.0 1.0 7 P30154,P30153 2 Fanconi anemia pathway 0.3239311163895531 0.1713805052472166 0.863924582555843 1.0 1.0 8 O15360,P35244,Q8TAF3,Q9NVI1,P27694,Q9BXW9,P15927 7 Free fatty acids regulate insulin secretion 0.5192649673977492 0.1709024759665351 0.8643004497674824 1.0 1.0 2 O60488 1 E2f mediated regulation of dna replication 0.2929221449607213 0.1698358514697572 0.8651392310971717 1.0 1.0 13 P30154,O43913,P30153 3 Synthesis of leukotrienes lt and eoxins ex 0.516301126259634 0.1655520639339289 0.8685094740313481 1.0 1.0 2 P09960 1 Biosynthesis of specialized proresolving mediators spms 0.516301126259634 0.1655520639339289 0.8685094740313481 1.0 1.0 2 P09960 1 Polo like kinase mediated events 0.3789744157201092 0.1633970112877348 0.8702058559083727 1.0 1.0 5 Q99640 1 Metabolism of fat soluble vitamins 0.404289449418641 0.1626059980568024 0.8708286640865532 1.0 1.0 4 Q6NUM9,P09455 2 Metalloprotease dubs 0.3217571979815987 0.1602458595728271 0.8726874054140861 1.0 1.0 7 O00487,O95630,Q96RL1,Q92783,Q9NXR7,Q15018 6 Alpha linolenic omega3 and linoleic omega6 acid metabolism 0.3209353618878419 0.157683840425842 0.8747059346514416 1.0 1.0 7 Q15067,P51659,P22307 3 Smad2 smad3 smad4 heterotrimer regulates transcription 0.3749629190151395 0.1537331576253457 0.8778201395466367 1.0 1.0 5 P27361,P28482,O75909,Q13547 4 Regulated necrosis 0.2717427762499408 0.1505385919740972 0.8803397056411093 1.0 1.0 19 Q14254,O43633,P07900,Q16543,P09429,Q9UNE7,Q9UQN3 7 Kinesins 0.2647484036417085 0.1489084799177837 0.8816258498141045 1.0 1.0 23 O60333,Q07866,Q9Y496,Q9BVA1,P68371,Q9H0B6,Q86Y91,P33176,O00139,O95235 10 Carboxyterminal post translational modifications of tubulin 0.3725835816788059 0.1481266640208725 0.8822428067186749 1.0 1.0 5 P68371 1 Signal amplification 0.3164315505792033 0.146957269369563 0.8831657481497235 1.0 1.0 8 Q16539,P63218,P63096,P08754 4 Protein methylation 0.3170080142475536 0.1456522500851716 0.8841959181676113 1.0 1.0 7 O60678,P38117,P15880,P11142,P55072,P13639 6 G beta gamma signalling through pi3kgamma 0.3950068039931588 0.1430492793179086 0.8862512620942493 1.0 1.0 4 P63218 1 Erks are inactivated 0.3149277277340584 0.1394223612655773 0.8891164031926917 1.0 1.0 7 P30154 1 Defects in cobalamin b12 metabolism 0.3687333135568165 0.1392536395598986 0.8892497231259271 1.0 1.0 5 Q96EY8,Q99707,Q9Y4U1,P22033 4 Cobalamin cbl vitamin b12 transport and metabolism 0.3687333135568165 0.1392536395598986 0.8892497231259271 1.0 1.0 5 Q96EY8,Q99707,Q9Y4U1,P22033 4 Nucleotide excision repair 0.2245707753466069 0.1371741483722362 0.8908931443363326 1.0 1.0 58 P35249,P41208,P40937,Q9UMS4,Q9UBW8,Q99627,P54727,O15514,Q9BT78,P40938,P49005,P23193,P61201,Q9UNS2 14 Gap junction trafficking and regulation 0.2955203320000554 0.1358539136170203 0.8919367692026108 1.0 1.0 11 P09496,P09497,P68371,P50570 4 Sars cov 1 infection 0.2736022915160012 0.1297181891859992 0.8967893912710068 1.0 1.0 15 P14314,P49841,O43633 3 Transcriptional regulation by small rnas 0.2405886990460421 0.1287786066775973 0.8975328339550972 1.0 1.0 38 Q99567,Q7Z3B4,Q9BVL2,O15514,Q9BTX1,P12270,Q8N1F7 7 Transport of the slbp dependant mature mrna 0.2425725240297912 0.1245394292469376 0.9008881833461218 1.0 1.0 30 Q99567,Q7Z3B4,Q9BVL2,Q9BTX1,P12270,Q8N1F7,Q86V81 7 Interferon signaling 0.2221803048287644 0.1226572331094999 0.9023785310954716 1.0 1.0 61 P10321,Q99567,Q96EE3,P46934,Q7Z3B4,Q9BVL2,P42224,P78344,P57740,Q14258,Q9BTX1,P12270,Q8WUM0,Q8N1F7,P04439,Q9Y4X5,Q9UII4,Q12899 18 Sulfur amino acid metabolism 0.2915469969558155 0.1224027682702435 0.9025800462353516 1.0 1.0 11 Q9UBX3,Q9BV57 2 Synthesis of diphthamide eef2 0.4884410195613533 0.1208774096924179 0.903788135403692 1.0 1.0 2 Q9BQC3 1 Attachment of gpi anchor to upar 0.382562277580071 0.1188567810788459 0.9053888226680424 1.0 1.0 4 Q969N2,Q9H490,Q96S52 3 Adaptive immune system 0.2478231239371101 0.1132158429733226 0.9098594355485384 1.0 1.0 195 P30154,Q9NZ08,Q15436,P46934,O43237,Q9UNM6,P31751,Q8N8S7,Q12846,P17980,P31946,P60604,P04439,Q07866,P48556,P63104,P49427,P30153,O75935,Q14999,Q10567,Q13153,P47755,Q9Y6G9,Q9UNE7,P43686,Q9Y496,O94874,Q9BSL1,O43865,Q14203,P28066,Q6UWE0,Q9H0B6,Q99538,Q93034,Q92990,Q13177,Q16763,O00231,P62191,P61289,Q13561,P52907,Q92530,P62195,P30101,P33176 48 The role of nef in hiv 1 replication and disease pathogenesis 0.2764692196175891 0.1078217468979629 0.9141370919243954 1.0 1.0 13 Q13177,P04439,Q9UI12 3 Signaling by ntrk3 trkc 0.4716869255855447 0.1045653171896875 0.9167207366621656 1.0 1.0 3 Q8WX92,P19174 2 Signal attenuation 0.4716869255855438 0.1045653171896864 0.9167207366621666 1.0 1.0 3 P27361,P28482 2 Downstream signaling of activated fgfr4 0.4716869255855366 0.1045653171896766 0.9167207366621744 1.0 1.0 3 Q06124,P19174 2 Downstream signaling of activated fgfr1 0.4716869255855366 0.1045653171896766 0.9167207366621744 1.0 1.0 3 Q06124,P19174 2 Downstream signaling of activated fgfr3 0.4716869255855366 0.1045653171896766 0.9167207366621744 1.0 1.0 3 Q06124,P19174 2 Downstream signaling of activated fgfr2 0.4716869255855366 0.1045653171896766 0.9167207366621744 1.0 1.0 3 Q06124,P19174 2 Ovarian tumor domain proteases 0.2939332898670459 0.1042819031006406 0.9169456388392696 1.0 1.0 10 Q6GQQ9,Q96FW1,Q7Z434,Q14258,P55072,P06493 6 Assembly and cell surface presentation of nmda receptors 0.2933386037784491 0.1024641752266085 0.9183882471742824 1.0 1.0 10 O14936,P07196,Q9BVA1,Q12959,P68371,Q14168 6 Linoleic acid la metabolism 0.4733254297569665 0.1008110996138568 0.919700415514698 1.0 1.0 2 O95864 1 Dna damage reversal 0.372182680901535 0.1004674013262763 0.9199732618369824 1.0 1.0 4 Q6P6C2,Q9C0B1,Q9H1I8 3 Activated ntrk2 signals through frs2 and frs3 0.4715471250740978 0.0986373540691472 0.921426210367898 1.0 1.0 2 Q06124 1 Stat5 activation downstream of flt3 itd mutants 0.4715471250740978 0.0986373540691472 0.921426210367898 1.0 1.0 2 Q06124 1 Tie2 signaling 0.4715471250740978 0.0986373540691472 0.921426210367898 1.0 1.0 2 Q06124 1 Frs mediated fgfr3 signaling 0.4715471250740978 0.0986373540691472 0.921426210367898 1.0 1.0 2 Q06124 1 Pi 3k cascade fgfr4 0.4715471250740978 0.0986373540691472 0.921426210367898 1.0 1.0 2 Q06124 1 Pi 3k cascade fgfr1 0.4715471250740978 0.0986373540691472 0.921426210367898 1.0 1.0 2 Q06124 1 Frs mediated fgfr1 signaling 0.4715471250740978 0.0986373540691472 0.921426210367898 1.0 1.0 2 Q06124 1 Stat5 activation 0.4715471250740978 0.0986373540691472 0.921426210367898 1.0 1.0 2 Q06124 1 Signaling by fgfr4 in disease 0.4715471250740978 0.0986373540691472 0.921426210367898 1.0 1.0 2 P19174 1 Frs mediated fgfr4 signaling 0.4715471250740978 0.0986373540691472 0.921426210367898 1.0 1.0 2 Q06124 1 Pi 3k cascade fgfr2 0.4715471250740978 0.0986373540691472 0.921426210367898 1.0 1.0 2 Q06124 1 Frs mediated fgfr2 signaling 0.4715471250740978 0.0986373540691472 0.921426210367898 1.0 1.0 2 Q06124 1 Signaling by flt3 itd and tkd mutants 0.4715471250740978 0.0986373540691472 0.921426210367898 1.0 1.0 2 Q06124 1 Pi 3k cascade fgfr3 0.4715471250740978 0.0986373540691472 0.921426210367898 1.0 1.0 2 Q06124 1 Regulation of runx1 expression and activity 0.370699881376039 0.0979732180808708 0.9219535599090644 1.0 1.0 4 Q00534,Q06124,Q13951 3 Ns1 mediated effects on host pathways 0.2316975378390342 0.0941212115400357 0.9250128708045348 1.0 1.0 32 Q99567,Q7Z3B4,Q9BVL2,Q9BTX1,Q86U42,Q8N1F7,P12270 7 Phenylalanine metabolism 0.4608848489721109 0.0904233508940144 0.927950801369853 1.0 1.0 3 P09417 1 Gaba synthesis release reuptake and degradation 0.4635447540011872 0.0893302778851749 0.9288194319795772 1.0 1.0 2 P51649 1 Global genome nucleotide excision repair gg ner 0.2332224739788452 0.0874234793528115 0.9303349070010896 1.0 1.0 41 P35249,P41208,P40937,Q9UBW8,Q99627,P54727,Q9BT78,P40938,P49005,P61201 10 Enos activation 0.4575545639881445 0.0863324842941794 0.9312021161346612 1.0 1.0 3 O75608 1 Regulation of innate immune responses to cytosolic dna 0.4565668544322551 0.0851433005504936 0.9321474664064922 1.0 1.0 3 Q9UJV9,Q9NZI8 2 Irf3 mediated activation of type 1 ifn 0.4564315352697113 0.0816959722809489 0.9348884813089264 1.0 1.0 2 Q9NZI8 1 Metabolic disorders of biological oxidation enzymes 0.3396618214179826 0.0803629900523602 0.9359485613276256 1.0 1.0 5 P48506,P48637,P48507,P22570 4 Wax and plasmalogen biosynthesis 0.3565134599429254 0.075778550783508 0.9395952810442644 1.0 1.0 4 O00116 1 Transcription coupled nucleotide excision repair tc ner 0.2241515480291753 0.0688100305469603 0.9451408337925882 1.0 1.0 51 P35249,P40937,Q9UMS4,Q9UBW8,Q99627,O15514,Q9BT78,P40938,P49005,P23193,P61201,Q9UNS2 12 Regulation of tp53 activity through methylation 0.4250148192056923 0.0546632120883768 0.9564067780206856 1.0 1.0 2 O14744 1 Condensation of prometaphase chromosomes 0.2759952465834936 0.0537979849565358 0.9570961149682122 1.0 1.0 10 Q9BPX3,P67870,Q15003,P19784,Q9NTJ3,O95347,P06493,O95067,P14635 9 Sumoylation of ubiquitinylation proteins 0.2337042618479076 0.0501830762708626 0.959976497739918 1.0 1.0 26 Q99567,Q7Z3B4,Q9BVL2,Q9BTX1,P12270,Q8N1F7 6 Sumoylation of sumoylation proteins 0.2337042618479076 0.0501830762708626 0.959976497739918 1.0 1.0 26 Q99567,Q7Z3B4,Q9BVL2,Q9BTX1,P12270,Q8N1F7 6 Regulation of glucokinase by glucokinase regulatory protein 0.2337042618479076 0.0501830762708626 0.959976497739918 1.0 1.0 26 Q99567,Q7Z3B4,Q9BVL2,Q9BTX1,P12270,Q8N1F7 6 Cell death signalling via nrage nrif and nade 0.2665433208748686 0.048484031669532 0.9613304903565314 1.0 1.0 11 Q9NY61,Q92888,P62258 3 Rhof gtpase cycle 0.2462713581728868 0.0480283456400187 0.9616936521145738 1.0 1.0 19 P12814,P20700 2 Translation of replicase and assembly of the replication transcription complex 0.3183536382863695 0.0463300073281221 0.9630472225924298 1.0 1.0 5 O43633 1 Mitotic spindle checkpoint 0.2107855548942421 0.0462052375675862 0.9631466679599718 1.0 1.0 61 P30154,Q92674,Q15005,P30153,O43237,Q96EA4,Q8NBT2,Q9Y6G9,Q96BD8,Q16763,O14777,Q9BS16 12 P75 ntr receptor mediated signalling 0.2447434891050013 0.0435433890971235 0.9652683778083924 1.0 1.0 17 Q9NQC3,Q13547,Q92888,Q9NY61,P62258 5 Ketone body metabolism 0.3274021352313185 0.0394120079468425 0.9685619063914364 1.0 1.0 4 P35914,P35610,Q86V21 3 Synthesis of ketone bodies 0.3274021352313185 0.0394120079468425 0.9685619063914364 1.0 1.0 4 P35914,P35610,Q86V21 3 Cell cycle mitotic 0.2768817542073895 0.0372429388215502 0.9702913021154173 1.0 1.0 274 P30154,Q14566,Q99567,Q92674,Q15005,O43237,Q9UNM6,Q7Z3B4,P31751,P17980,Q9UQE7,P42166,P57740,Q9H0U4,Q86XL3,Q99640,Q9BS16,P20700,P48556,P07900,P40937,P30153,O75935,Q08379,Q8NBT2,Q9BRT9,Q9Y6G9,O60763,Q8IXJ6,Q9BVL2,P43686,P49643,P53990,Q96CS2,Q14203,P61981,P28066,Q9BTX1,Q8N1F7,Q16763,P62258,Q01105,O14777,O00231,O43913,P62191,O43633,P02545,P61289,P41208,Q8WVM7,P04818,Q96EA4,Q13561,Q92530,P62195,O75330,P49841,P12270,O94927,Q96BD8,P49005 62 Endosomal vacuolar pathway 0.4029895277403028 0.0360720581924947 0.971224902154926 1.0 1.0 3 P04439 1 Activation of ppargc1a pgc 1alpha by phosphorylation 0.3858921161825746 0.033891386434281 0.9729637618736148 1.0 1.0 2 Q16539 1 Fbxw7 mutants and notch1 in cancer 0.3847065797273286 0.0334435667931554 0.9733208678013454 1.0 1.0 2 P63208 1 Reduction of cytosolic ca levels 0.3895641861844084 0.0280219696567778 0.977644628773462 1.0 1.0 3 P30626,P16615 2 Platelet calcium homeostasis 0.3895641861844084 0.0280219696567778 0.977644628773462 1.0 1.0 3 P30626,P16615 2 Prolactin receptor signaling 0.3848206344500472 0.0255244456913217 0.9796366499952004 1.0 1.0 3 Q06124,P63208 2 Establishment of sister chromatid cohesion 0.2668927557057426 0.0203509294607448 0.9837634283503308 1.0 1.0 8 Q8WVM7 1 Signal transduction by l1 0.2615422761883558 0.0197540078393239 0.984239607143276 1.0 1.0 10 P27361,P36507,Q13153 3 Metabolism of nitric oxide nos3 activation and regulation 0.2813162993052405 0.018444760816963 0.9852840445384174 1.0 1.0 6 O75608,P07900 2 Aflatoxin activation and detoxification 0.2957913455838789 0.018122081309762 0.9855414625053004 1.0 1.0 2 Q99735 1 Downregulation of tgf beta receptor signaling 0.2633124789739033 0.0180758134773489 0.9855783728485508 1.0 1.0 7 Q9Y4E8,Q9UNE7 2 Uptake and function of diphtheria toxin 0.3022707093530575 0.0171374333618169 0.9863269757875376 1.0 1.0 4 P07900 1 Gap junction degradation 0.2761154803473682 0.0113542183641466 0.9909408391162464 1.0 1.0 6 P09497,P50570 2 Transcriptional activity of smad2 smad3 smad4 heterotrimer 0.2572786690433754 0.0108404176514052 0.9913507675255488 1.0 1.0 10 P27361,O75376,Q13547,O75909,Q13573,P28482,Q9UPN9,P09874,P50750 9 Ephb mediated forward signaling 0.2343989209920696 0.0099380901368638 0.9920706818401686 1.0 1.0 19 Q13464,Q13153 2 Pyrimidine salvage 0.3403498369404116 0.0094133850825519 0.9924893163004608 1.0 1.0 3 Q9BZX2,Q08623 2 Interactions of vpr with host cellular proteins 0.2133268111609688 0.0086732301485904 0.993079850333544 1.0 1.0 33 P12235,Q99567,Q7Z3B4,Q9BVL2,Q9BTX1,P12270,Q8N1F7 7 Uptake and function of anthrax toxins 0.3356062852060448 0.0083355857425 0.9933492418488848 1.0 1.0 3 Q02750,P36507 2 Formation of incision complex in gg ner 0.2419003527991083 0.0071554969354323 0.9942907881900768 1.0 1.0 13 P54727 1 Rna polymerase iii transcription initiation from type 1 promoter 0.2473069833103127 0.0045200994487212 0.9963934947175072 1.0 1.0 11 O15160 1 Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation 0.2748406413353923 0.0011360575918318 0.9990935573822745 1.0 1.0 3 P07900 1