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interpro_active_site/advanced/idx2term.json

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+{}

interpro_active_site/basic/idx2term.json

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+{}

interpro_active_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:fa498f6a5f48976117ec056816d80886d806f507e6cf7d5285e35f5865b36fdb
+size 71315

interpro_active_site/df_merge.tsv

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+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_active_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3210,
+    "annotations_size": 53,
+    "title": "Average number of proteins per term",
+    "value": 2.830188679245283
+}

interpro_active_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C405/C405_val_log2fc"}

interpro_active_site/result.tsv

@@ -0,0 +1,6 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Serine carboxypeptidase, serine active site [IPR018202]	0.9887745556594952	2.0056771528537403	0.0448907043521709	0.9123377104056084	0.4556089754091552	3	Q9H3G5,Q9HB40	2
+Histidine acid phosphatase active site [IPR033379]	0.8968204488778071	1.3719745268465553	0.1700713678621168	0.99994881300515	0.5792598485250653	2	Q9NPH0	1
+Cysteine peptidase, cysteine active site [IPR000169]	0.3785469285936969	0.0703692172724495	0.943899791550763	1.0	1.0	3	P17655,P07384	2
+ATP:guanido phosphotransferase active site [IPR022415]	0.3809226932668401	0.0414180494090254	0.9669626237955988	1.0	1.0	2	P12277	1
+Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]	0.2877182044887866	0.0378157617981006	0.96983457726342	1.0	1.0	2	Q9NQ88	1

interpro_active_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenosine/AMP deaminase active site [IPR006650]", "Adenylosuccinate synthase,  active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Coenzyme A transferase active site [IPR004164]", "Cysteine peptidase, cysteine active site [IPR000169]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "DNA topoisomerase, type IA, active site [IPR023406]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glutaredoxin active site [IPR011767]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Peptidase family C14A, His active site [IPR016129]", "Peptidase family C14A, cysteine active site [IPR033139]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]", "Uracil-DNA glycosylase, active site [IPR018085]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADA", "ADSS", "AKT2", "APEH", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "AURKA", "AURKB", "BLMH", "CAMK2D", "CAMK2G", "CAPN1", "CAPN2", "CASP2", "CASP3", "CASP6", "CDC42BPB", "CDC7", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK6", "CHEK1", "CHEK2", "CHUK", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "DLD", "DNMT1", "DUSP11", "DUSP3", "EIF2AK2", "EPHA7", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLRX", "GLUD1", "GSK3A", "GSK3B", "GSR", "HADHB", "HMGCL", "HMGCS1", "IKBKB", "LDHA", "LDHB", "LONP1", "LYN", "MAP2K1", "MAP3K4", "MAP3K7", "MAP4K4", "MAPK1", "MAPK3", "MARK2", "MARK3", "MDH1", "MDH2", "NEK9", "NME1", "NME2", "OXCT1", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKMYT1", "PKN2", "PLK1", "PREP", "PRKACA", "PRPF4B", "PTK7", "PTPN1", "PTPN11", "RIPK1", "RNGTT", "ROCK1", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SRPK2", "SUCLG1", "TALDO1", "TAOK2", "TIGAR", "TOP1", "TOP3A", "TPI1", "TPP2", "TRIO", "TTK", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "UMPS", "UNG", "VRK1", "VRK2", "WNK1", "YES1"], "leading_proteins": ["ACP6", "CAPN1", "CAPN2", "CKB", "CPVL", "SCPEP1", "TIGAR"]}

interpro_binding_site/advanced/idx2term.json

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+{}

interpro_binding_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "EF-Hand 1, calcium-binding site [IPR018247]"}

interpro_binding_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:e3c6969723cf02476aa49a2d09cbb5bf1065f971f3aa4dcf82c4e35eb03cec1e
+size 71063

interpro_binding_site/df_merge.tsv

@@ -0,0 +1 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_binding_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3210,
+    "annotations_size": 31,
+    "title": "Average number of proteins per term",
+    "value": 4.870967741935484
+}

interpro_binding_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C405/C405_val_log2fc"}

interpro_binding_site/result.tsv

@@ -0,0 +1,4 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Peptidase M16, zinc-binding site [IPR001431]	0.5244552344918195	0.7285857955915519	0.4662550699384766	0.9999999964734776	1.0	5	Q10713,O43847,P22695	3
+EF-Hand 1, calcium-binding site [IPR018247]	0.416308730968922	0.0555651279174334	0.955688245456102	1.0	1.0	36	P31949,P80303,Q9BPX6,Q9NWM8,Q02818,Q9Y680,Q14257,Q9BRK5,O43852	9
+PPM-type phosphatase, divalent cation binding [IPR000222]	0.3438279301745712	0.0388070637901883	0.9690442129883216	1.0	1.0	2	Q9H0C8	1

interpro_binding_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Coenzyme A transferase binding site [IPR004163]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]", "Ureohydrolase, manganese-binding site [IPR020855]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT2", "APEX1", "APEX2", "ARG2", "AURKA", "AURKB", "BPNT1", "CALU", "CAMK2D", "CAMK2G", "CAPN1", "CAPN2", "CAPNS1", "CDC42BPB", "CDC7", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK6", "CHEK1", "CHUK", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DCTD", "DLAT", "DLST", "EHD1", "EHD4", "EIF2AK2", "EPHA7", "EPS15", "FKBP10", "FKBP14", "FKBP7", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "GSK3B", "HASPIN", "HK1", "HK2", "HMBS", "IDE", "ILKAP", "IQCB1", "IQGAP1", "IQGAP2", "IQGAP3", "ITSN2", "LETM1", "LYN", "MACF1", "MAP2K1", "MAP3K4", "MAP3K7", "MAP4K4", "MAPK1", "MAPK14", "MAPK3", "MARK2", "MARK3", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH14", "MYH9", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "MYO1E", "MYO5A", "NFS1", "NRDC", "NUCB1", "NUCB2", "OXCT1", "OXSR1", "PA2G4", "PAK2", "PAK4", "PC", "PCCA", "PDCD6", "PEF1", "PGD", "PKMYT1", "PKN2", "PLCG1", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PPM1G", "PRKACA", "PRKCSH", "PSAT1", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK1", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "SRPK2", "STK26", "STK3", "STK4", "TAOK2", "TKT", "TTK", "TUBB", "TUBB4B", "TUBB6", "UBE3C", "UQCRC2", "VRK1", "YES1"], "leading_proteins": ["CALU", "FKBP14", "FKBP7", "ILKAP", "MICU1", "NRDC", "NUCB1", "NUCB2", "PMPCA", "RCN2", "S100A11", "SDF4", "UQCRC2"]}

interpro_conserved_site/advanced/idx2term.json

@@ -0,0 +1 @@
+{}

interpro_conserved_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "ABC transporter-like, conserved site [IPR017871]"}

interpro_conserved_site/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:358c623323a5f8dcbc69d1ea7fb4920c77f7658c8dfee5fc557d453d4e74dbb6
+size 71088

interpro_conserved_site/df_merge.tsv

@@ -0,0 +1 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_conserved_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3210,
+    "annotations_size": 277,
+    "title": "Average number of proteins per term",
+    "value": 2.7617328519855597
+}

interpro_conserved_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C405/C405_val_log2fc"}

interpro_conserved_site/result.tsv

@@ -0,0 +1,29 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Proteasome beta-type subunit, conserved site [IPR016050]	0.7478621873595291	1.7951296393602691	0.0726330474392753	0.9999999991514108	0.7193359242863865	8	P28072,P20618,P28070,P49721	4
+Mini-chromosome maintenance, conserved site [IPR018525]	0.7190506064647937	1.7028781264444324	0.0885908782433086	0.999999999993072	0.7193359242863865	6	Q14566	1
+Amyloidogenic glycoprotein,  copper-binding domain conserved site [IPR019744]	0.969139650872818	1.6923774337489452	0.0905740321898784	0.9999999999962108	0.7193359242863865	2	P05067	1
+Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]	0.969139650872818	1.6923774337489452	0.0905740321898784	0.9999999999962108	0.7193359242863865	2	P05067	1
+Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]	0.969139650872818	1.6923774337489452	0.0905740321898784	0.9999999999962108	0.7193359242863865	2	P05067	1
+Haem oxygenase conserved site [IPR018207]	0.960099750623442	1.6522971655650085	0.0984739868496693	0.999999999999662	0.7193359242863865	2	P30519	1
+Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]	0.8814902210829298	1.5611977614995325	0.1184770970139232	0.9999999999999992	0.7193359242863865	3	Q8N4Q0	1
+Ribosomal protein L24/L26, conserved site [IPR005825]	0.9217581047381556	1.4822807781353042	0.1382656006936313	1.0	0.7372774418348166	2	P61254	1
+Intermediate filament protein, conserved site [IPR018039]	0.6248374537323498	1.238634095444362	0.2154810354280747	1.0	0.8290034279663432	8	P08670,P48681,P07196	3
+Clathrin adaptor, mu subunit, conserved site [IPR018240]	0.7659487901180455	1.0818434485182078	0.2793220967504939	1.0	0.9301109680851424	3	Q9BXS5	1
+HMG box A DNA-binding domain, conserved site [IPR017967]	0.7469545483839879	1.0047348757852528	0.3150245299475895	1.0	0.9478729622173272	3	P09429	1
+Sterol reductase, conserved site [IPR018083]	0.8064214463840429	0.9796409247435216	0.3272633962034301	1.0	0.9478729622173272	2	Q14739	1
+3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]	0.7218584346741556	0.9043988313405984	0.36578395764539	1.0	0.951215752396876	3	Q16836,Q08426	2
+Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]	0.7880299251870349	0.9025785894118216	0.3667495940747449	1.0	0.951215752396876	2	P04439	1
+Ribosomal S11, conserved site [IPR018102]	0.7877182044887805	0.901284389102996	0.3674371317922951	1.0	0.951215752396876	2	P82912	1
+Syntaxin/epimorphin, conserved site [IPR006012]	0.4210816616879239	0.3768636802683192	0.7062749136786264	1.0	1.0	6	O15400,Q9P2W9	2
+Polyprenyl synthetase, conserved site [IPR033749]	0.6069201995012525	0.2753003560018773	0.7830854909828999	1.0	1.0	2	O95749	1
+4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]	0.5201122544433903	0.2481919044412362	0.8039859297538348	1.0	1.0	3	O00217,P61221	2
+Dynein light chain, type 1/2, conserved site [IPR019763]	0.5863466334164649	0.2276895499574253	0.8198875970036295	1.0	1.0	2	P63167	1
+Alpha-D-phosphohexomutase, conserved site [IPR016066]	0.5358478802992588	0.1369859408420218	0.8910419079282832	1.0	1.0	2	Q96G03	1
+ABC transporter-like, conserved site [IPR017871]	0.3719254865922355	0.1262262989722835	0.8995527942899284	1.0	1.0	14	P08183,O14678,P61221,O75027,P33527	5
+Ribosomal protein L24e, conserved site [IPR023442]	0.5271197007481367	0.1250096917821756	0.9005158775991444	1.0	1.0	2	P83731	1
+Clathrin adaptor complex, small chain [IPR000804]	0.50311720698255	0.0972991880987855	0.9224888007460847	1.0	1.0	2	Q92572	1
+Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]	0.475997506234422	0.074347053856121	0.9407342370398122	1.0	1.0	2	Q00796	1
+S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]	0.4750623441396589	0.0736970869958681	0.9412514167281432	1.0	1.0	2	O43865	1
+Phosphorylase pyridoxal-phosphate attachment site [IPR035090]	0.3993142144638471	0.0439918543154196	0.964910896897734	1.0	1.0	2	P06737	1
+Thioredoxin, conserved site [IPR017937]	0.3221477353115225	0.0223784724599701	0.982146052539941	1.0	1.0	13	Q9H1E5,Q9H3N1,O95881,Q99757	4
+DnaJ domain, conserved site [IPR018253]	0.3179966406450039	0.0212413458195034	0.9830531325191948	1.0	1.0	12	Q96KC8,O60884	2

interpro_conserved_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Aldose 1-epimerase, conserved site [IPR018052]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Amyloidogenic glycoprotein,  copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Bromodomain, conserved site [IPR018359]", "CAMSAP, spectrin and Ca2+/calmodulin-binding region [IPR031372]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific,  conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA mismatch repair, conserved site [IPR014762]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "Dihydroorotate dehydrogenase, conserved site [IPR001295]", "DnaJ domain, conserved site [IPR018253]", "Dpy-30 motif [IPR007858]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Endonuclease III-like, conserved site-2 [IPR004036]", "Endonuclease III-like, iron-sulphur cluster loop motif [IPR003651]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Ependymin, conserved site [IPR018224]", "Ephrin, conserved site [IPR019765]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "GoLoco motif [IPR003109]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif [IPR000445]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site [IPR023076]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysophospholipase patatin, conserved site [IPR001423]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NADH:ubiquinone oxidoreductase, subunit 1, conserved site [IPR018086]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase, RluC/RluD, conserved site [IPR006224]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P,  conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S14, conserved site [IPR018271]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class V, conserved site [IPR001426]", "Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6, conserved site [IPR018168]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPA, conserved site [IPR022658]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]", "Zinc finger, XPA-type, conserved site [IPR022652]"], "available_proteins": ["AAAS", "ABCB1", "ABCB10", "ABCB7", "ABCC1", "ABCC4", "ABCD1", "ABCD3", "ABCD4", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACSS1", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "AP3S1", "APEX1", "APLP2", "APP", "ARHGEF7", "ARIH2", "ARSA", "ATAD1", "ATAD2", "ATP5C1", "ATP5O", "ATR", "BAG6", "BAX", "BAZ1A", "BAZ1B", "BCAT1", "BCAT2", "BCS1L", "BLM", "BOP1", "BPNT1", "BPTF", "BRCA1", "BRD2", "BRD4", "BUD31", "CAD", "CALR", "CAMSAP3", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC40", "CDH2", "CHAF1B", "CHD1", "CHD1L", "CHD2", "CHD4", "CLGN", "CMPK1", "CNDP2", "COPA", "COQ6", "CORO1C", "CPOX", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYP51A1", "DCAF13", "DCAF7", "DCPS", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHFR", "DHODH", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIS3", "DLG1", "DLG3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJB12", "DNAJB4", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC16", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNM3", "DNMT1", "DPY30", "DRG1", "DRG2", "DSC3", "DSG2", "DTYMK", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECT2", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EFNB1", "EHHADH", "EIF3I", "EIF4A1", "EIF4A3", "EIF4E", "EIF4E2", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPDR1", "EPHA7", "EPN1", "EPRS", "EPS15", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXC1", "FOXK1", "FOXK2", "FUCA1", "FUCA2", "GAA", "GALK1", "GALM", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GGPS1", "GLA", "GLB1", "GLO1", "GMPPA", "GMPPB", "GNB1", "GNPDA1", "GNS", "GOLGA2", "GPHN", "GPI", "GPSM1", "GRHPR", "GRWD1", "GSPT1", "GUF1", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCR", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSD17B8", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "ILVBL", "IMPDH1", "IMPDH2", "INA", "IQGAP1", "IQGAP2", "IQGAP3", "IVD", "KAT2A", "KDM2A", "KDM5A", "KDSR", "KIF11", "KIF13B", "KIF14", "KIF18A", "KIF1A", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFC1", "LAMP1", "LARS", "LARS2", "LBR", "LDLR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK14", "MAPK3", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME2", "MGST2", "MIF", "MKRN2", "MPI", "MPP1", "MPP2", "MPP5", "MPP6", "MPP7", "MPST", "MRPL13", "MRPL24", "MRPL3", "MRPS11", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MVK", "ND1", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NEFL", "NEFM", "NES", "NF1", "NF2", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD2", "NSF", "NTHL1", "NUBP2", "NUBPL", "NUDT1", "NUDT12", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCGF6", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PEBP1", "PEPD", "PEX1", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PHF14", "PHF3", "PHF8", "PHGDH", "PHIP", "PI4KA", "PI4KB", "PIK3C2A", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PMS1", "PNP", "PNPLA6", "POLA1", "POLD1", "POLR1B", "POLR1C", "POLR2B", "POLR2E", "POLR3B", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL3", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS1", "PRPS2", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RCL1", "RDH13", "RDX", "RECQL5", "RIDA", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RPUSD2", "RRP9", "RSF1", "RSL24D1", "RTCA", "RTN4IP1", "S100A11", "SART1", "SBDS", "SCAF11", "SCD", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC27A4", "SLIT2", "SMARCA4", "SMS", "SMU1", "SNRNP40", "SNU13", "SORD", "SPATA5", "SPATA5L1", "SPTBN1", "SPTBN2", "SRCAP", "SRM", "STMN1", "STX10", "STX12", "STX18", "STX4", "STX5", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SV2A", "SYNE1", "SYNE2", "TAP1", "TAP2", "TBL1XR1", "TBL3", "TCP1", "TFB1M", "THOC6", "TK1", "TLE3", "TLN1", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM13", "TRIM24", "TRIM25", "TRIM27", "TRIM28", "TRIM33", "TRIP13", "TRMT11", "TSFM", "TSPAN6", "TTF2", "TUBB", "TUBB4B", "TUBB6", "TUFM", "TXN2", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UHRF1", "UIMC1", "USP1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP33", "USP34", "USP36", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4B", "WARS", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR5", "WDR61", "WDR77", "XPA", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZMYND8"], "leading_proteins": ["ABCB1", "ABCB7", "ABCC1", "ABCD4", "ABCE1", "AHCYL1", "AP1M1", "AP3S1", "APP", "DNAJA2", "DNAJC1", "DYNLL1", "EHHADH", "GGPS1", "HADH", "HLA-A", "HMGB1", "HMOX2", "LBR", "MCM6", "MRPS11", "NDUFS8", "NEFL", "NES", "PGM2", "PSMB1", "PSMB2", "PSMB4", "PSMB6", "PYGL", "RPL24", "RPL26", "SORD", "STX18", "STX7", "TMX1", "TMX4", "TXN2", "TXNDC12", "VIM", "ZADH2"]}

interpro_domain/advanced/idx2term.json

@@ -0,0 +1 @@
+{}

interpro_domain/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]", "1": "Phox homology [IPR001683]", "2": "ABC transporter-like, ATP-binding domain [IPR003439]", "3": "EF-hand domain [IPR002048]", "4": "TGS [IPR004095]"}

interpro_domain/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:50a23c81f7f945ab31cfdb389d46d518831cabd2e6f21128fbcf06aa9649f99e
+size 76819

interpro_domain/df_merge.tsv

@@ -0,0 +1,2 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	4	6	2.2580972271485957	0.023939598482888	2.813106796116505	6.104368932038835	1.6405397264547834	0.1100883340733615	1.2852875686886795	0.8042848477475721	1.100790504333474	0.1612592696854457	1.0	1.0	1.0	0.0001405335592956	0.0001560226497295

interpro_domain/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3210,
+    "annotations_size": 2696,
+    "title": "Average number of proteins per term",
+    "value": 2.1839762611275964
+}

interpro_domain/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C405/C405_val_log2fc"}

interpro_domain/result.tsv

@@ -0,0 +1,235 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Reticulon [IPR003388]	0.9607586074611328	2.4353888697751365	0.0148757932446705	1.0	0.9719797416416732	4	O95197	1
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	0.8463470586869256	2.2580972271485953	0.023939598482888	1.0	0.9719797416416732	6	O15173,O00264,Q9UMX5,O95864	4
+TRAM/LAG1/CLN8 homology domain [IPR006634]	0.879508777150089	2.1141958577694977	0.0344985425242276	1.0	0.9719797416416732	4	Q96G23,Q15629	2
+Alcohol dehydrogenase, N-terminal [IPR013154]	0.8007638114028379	1.9241433208209004	0.0543366212888321	1.0	0.9719797416416732	5	Q8N4Q0	1
+KOW [IPR005824]	0.758789018036756	1.8795933544774952	0.0601635196626839	1.0	0.9719797416416732	6	Q96A35,P61254	2
+Polyketide synthase, enoylreductase domain [IPR020843]	0.7552883207935102	1.864143494969016	0.0623015558970205	1.0	0.9719797416416732	6	Q99536,Q8N4Q0	2
+MHC class I-like antigen recognition-like [IPR011161]	0.7969174511674422	1.777650286583296	0.0754613092855627	1.0	0.9719797416416732	4	P04439,Q9UNN8	2
+MCM, AAA-lid domain [IPR041562]	0.7190506064647937	1.7028781264444324	0.0885908782433086	1.0	0.9719797416416732	6	Q14566	1
+MCM OB domain [IPR033762]	0.7190506064647937	1.7028781264444324	0.0885908782433086	1.0	0.9719797416416732	6	Q14566	1
+MCM domain [IPR001208]	0.7190506064647937	1.7028781264444324	0.0885908782433086	1.0	0.9719797416416732	6	Q14566	1
+MCM N-terminal domain [IPR027925]	0.7190506064647937	1.7028781264444324	0.0885908782433086	1.0	0.9719797416416732	6	Q14566	1
+Amyloidogenic glycoprotein, heparin-binding [IPR015849]	0.969139650872818	1.6923774337489452	0.0905740321898784	1.0	0.9719797416416732	2	P05067	1
+Beta-amyloid precursor protein C-terminal [IPR019543]	0.969139650872818	1.6923774337489452	0.0905740321898784	1.0	0.9719797416416732	2	P05067	1
+Amyloidogenic glycoprotein, extracellular [IPR008154]	0.969139650872818	1.6923774337489452	0.0905740321898784	1.0	0.9719797416416732	2	P05067	1
+Pancreatic trypsin inhibitor Kunitz domain [IPR002223]	0.969139650872818	1.6923774337489452	0.0905740321898784	1.0	0.9719797416416732	2	P05067	1
+Amyloidogenic glycoprotein, E2 domain [IPR024329]	0.969139650872818	1.6923774337489452	0.0905740321898784	1.0	0.9719797416416732	2	P05067	1
+Amyloidogenic glycoprotein, copper-binding [IPR011178]	0.969139650872818	1.6923774337489452	0.0905740321898784	1.0	0.9719797416416732	2	P05067	1
+Fatty acid desaturase domain [IPR005804]	0.9688279301745636	1.6909956680289435	0.0908376300197046	1.0	0.9719797416416732	2	O15121	1
+Fatty acid hydroxylase [IPR006694]	0.9663341645885292	1.679940651595187	0.0929688633981087	1.0	0.9719797416416732	2	O75845	1
+MD-2-related lipid-recognition domain [IPR003172]	0.9329800498753122	1.53201911421087	0.1255177180333297	1.0	0.9719797416416732	2	P17900	1
+LEM domain [IPR003887]	0.6807480293475346	1.5299933738658047	0.1260183690739742	1.0	0.9719797416416732	6	Q86XL3,P42166	2
+Alcohol dehydrogenase-like, C-terminal [IPR013149]	0.6743836321471078	1.5010543794159616	0.1333414970808601	1.0	0.9719797416416732	6	Q8N4Q0	1
+Ribosomal protein L26/L24, KOW domain [IPR041988]	0.9217581047381556	1.4822807781353042	0.1382656006936313	1.0	0.9719797416416732	2	P61254	1
+Intermediate filament head, DNA-binding domain [IPR006821]	0.7219705917636713	1.4655667378765873	0.1427663584476768	1.0	0.9719797416416732	4	P08670,P07196	2
+Mu homology domain [IPR028565]	0.7207575347450271	1.4604832658376732	0.144157303343879	1.0	0.9719797416416732	4	Q9Y2T2,Q9BXS5	2
+P-type ATPase, haloacid dehalogenase domain [IPR044492]	0.6641141274093088	1.4542472722511142	0.1458777632243908	1.0	0.9719797416416732	6	P20020,Q9HD20,P23634	3
+FAD dependent oxidoreductase [IPR006076]	0.7182405061965704	1.4499335320728557	0.1470770554339793	1.0	0.9719797416416732	4	Q96CU9	1
+FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]	0.6817066032704754	1.4450462489542213	0.148444895354801	1.0	0.9719797416416732	11	O00170,Q9NWM8,Q9Y680,P26885,P62942	5
+N-acetylgalactosaminyltransferase [IPR045885]	0.7131688454122909	1.4286698913858056	0.1530991355266717	1.0	0.9719797416416732	4	Q8N4A0,Q10472	2
+Protein kinase, C-terminal [IPR017892]	0.7092106692717307	1.4120696218181412	0.1579294623999603	1.0	0.9719797416416732	4	P31751,P51812	2
+HDGF-related, PWWP domain [IPR035496]	0.8449629172301018	1.4087731591766095	0.1589022542094138	1.0	0.9719797416416732	3	Q7Z4V5	1
+Post-SET domain [IPR003616]	0.6975922379055881	1.3633270244398998	0.1727794686627244	1.0	0.9719797416416732	4	O96028	1
+Zinc finger, RanBP2-type [IPR001876]	0.6525228530217033	1.3476400498350745	0.1777741826366012	1.0	0.9719797416416732	9	P52756,Q01844,P98175,O95218	4
+FAD linked oxidase, N-terminal [IPR006094]	0.8893391521197025	1.3389761377413598	0.1805784412904829	1.0	0.9719797416416732	2	Q15392	1
+FAD-binding domain, PCMH-type [IPR016166]	0.8893391521197025	1.3389761377413598	0.1805784412904829	1.0	0.9719797416416732	2	Q15392	1
+OCRE domain [IPR041591]	0.886221945137158	1.3252436014300226	0.1850903681831495	1.0	0.9822906153971872	2	P52756	1
+NOPS [IPR012975]	0.8235110695353947	1.3194126681456038	0.1870311888939275	1.0	0.9825950994418978	3	P23246,Q8WXF1	2
+Extracellular Endonuclease, subunit A [IPR020821]	0.8846633416458858	1.318381366204811	0.1873760153664776	1.0	0.9825950994418978	2	O94919	1
+DNA/RNA non-specific endonuclease [IPR001604]	0.8846633416458858	1.318381366204811	0.1873760153664776	1.0	0.9825950994418978	2	O94919	1
+MRH domain [IPR044865]	0.8181115314218456	1.2969641223784865	0.1946435316752559	1.0	0.9904447419071662	3	P20645	1
+Sterol-sensing domain [IPR000731]	0.8731296758104756	1.267693890122836	0.2049072875607311	1.0	1.0	2	O15118	1
+Saposin B type domain [IPR008139]	0.8721945137157128	1.2635919371934066	0.2063765290316146	1.0	1.0	2	P07602	1
+Intermediate filament, rod domain [IPR039008]	0.6248374537323498	1.238634095444362	0.2154810354280747	1.0	1.0	8	P08670,P48681,P07196	3
+Phospholipase D/Transphosphatidylase [IPR001736]	0.8653366583541164	1.2335512019337649	0.217370186171012	1.0	1.0	2	Q8IV08	1
+Major facilitator superfamily domain [IPR020846]	0.6655483032280893	1.228969234163234	0.219083341319644	1.0	1.0	4	Q7L0J3	1
+Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375]	0.6644300196617356	1.224287867498935	0.2208436521416423	1.0	1.0	4	Q4J6C6	1
+Zinc finger, CHHC-type [IPR012996]	0.7904583723105714	1.1824402821833635	0.2370310476628463	1.0	1.0	3	P31943,P55795	2
+MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]	0.7882756470221506	1.1734408659012805	0.2406190574603837	1.0	1.0	3	P04439,P10321	2
+MHC class I, alpha chain, C-terminal [IPR010579]	0.7882756470221506	1.1734408659012805	0.2406190574603837	1.0	1.0	3	P04439,P10321	2
+Immunoglobulin C1-set [IPR003597]	0.7882756470221506	1.1734408659012805	0.2406190574603837	1.0	1.0	3	P04439,P10321	2
+Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]	0.8469451371571092	1.1533915858177946	0.2487496935326731	1.0	1.0	2	Q9Y282	1
+Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]	0.8469451371571092	1.1533915858177946	0.2487496935326731	1.0	1.0	2	Q9Y282	1
+Glycogen synthase kinase 3, catalytic domain [IPR039192]	0.841957605985039	1.1317715767631795	0.2577304803095979	1.0	1.0	2	P49840	1
+Peptidase S9A, N-terminal domain [IPR023302]	0.8413341645885304	1.1290730417782722	0.258867022470292	1.0	1.0	2	Q4J6C6	1
+Mst1 SARAH domain [IPR024205]	0.8316708229426455	1.087366519616682	0.2768748614226268	1.0	1.0	2	Q13043	1
+SARAH domain [IPR011524]	0.8316708229426455	1.087366519616682	0.2768748614226268	1.0	1.0	2	Q13043	1
+Translation initiation factor IF2/IF5 domain [IPR002735]	0.830735660847882	1.0833430538527336	0.2786561818856059	1.0	1.0	2	P55010	1
+Fibronectin type II domain [IPR000562]	0.8279301745635926	1.0712868372285922	0.2840404764580055	1.0	1.0	2	P11717	1
+Plasma membrane calcium transporting P-type ATPase, C-terminal [IPR022141]	0.8257481296758122	1.061924856174166	0.2882697999662005	1.0	1.0	2	P23634	1
+Ribosomal protein L18e/L15P [IPR021131]	0.7569827203782808	1.0453373332872726	0.2958670887712185	1.0	1.0	3	P46776	1
+Acyl-CoA oxidase, C-terminal [IPR002655]	0.8201371571072338	1.03791448086461	0.299309871179813	1.0	1.0	2	O15254	1
+Thiamine pyrophosphate enzyme, central domain [IPR012000]	0.8182668329177076	1.029932084342096	0.3030418881711818	1.0	1.0	2	Q9UJ83	1
+Thiamine pyrophosphate enzyme, C-terminal TPP-binding [IPR011766]	0.8182668329177076	1.029932084342096	0.3030418881711818	1.0	1.0	2	Q9UJ83	1
+Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain [IPR012001]	0.8182668329177076	1.029932084342096	0.3030418881711818	1.0	1.0	2	Q9UJ83	1
+PA domain [IPR003137]	0.8135910224438923	1.0100244458143377	0.3124835781437771	1.0	1.0	2	Q8TCT8	1
+Cation-transporting P-type ATPase, N-terminal [IPR004014]	0.5869027188673331	0.9946761988282312	0.3198937740260477	1.0	1.0	5	P20020,P05023,P23634	3
+Cation-transporting P-type ATPase, C-terminal [IPR006068]	0.5869027188673331	0.9946761988282312	0.3198937740260477	1.0	1.0	5	P20020,P05023,P23634	3
+Tim44-like domain [IPR007379]	0.8082917705735682	0.9875499069656974	0.3233731295830147	1.0	1.0	2	Q9BRJ2	1
+Peptidase M16, N-terminal [IPR011765]	0.5620963601435093	0.9683059233610696	0.3328916073901782	1.0	1.0	7	Q10713,O43847,Q5JRX3,P22695	4
+Peptidase M16, C-terminal [IPR007863]	0.5620963601435093	0.9683059233610696	0.3328916073901782	1.0	1.0	7	Q10713,O43847,Q5JRX3,P22695	4
+PWWP domain [IPR000313]	0.5598008700246159	0.9578194779694278	0.3381537955517104	1.0	1.0	7	O96028,Q7Z4V5	2
+FKBP3, basic tilted helix bundle domain [IPR041200]	0.8001870324189548	0.9533695921179224	0.340402842532753	1.0	1.0	2	Q00688	1
+SUN domain [IPR012919]	0.7989401496259374	0.94813289121029	0.3430618057479475	1.0	1.0	2	Q9ULT8	1
+EF-hand, Ca insensitive [IPR014837]	0.7252884315559756	0.9179906380602832	0.3586237671741843	1.0	1.0	3	P12814,O43707	2
+Cysteine-rich flanking region, C-terminal [IPR000483]	0.7895885286783066	0.909055916172048	0.3633206108747284	1.0	1.0	2	Q13641	1
+Leucine-rich repeat N-terminal domain [IPR000372]	0.7895885286783066	0.909055916172048	0.3633206108747284	1.0	1.0	2	Q13641	1
+3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108]	0.7218584346741556	0.9043988313405984	0.36578395764539	1.0	1.0	3	Q16836,Q08426	2
+3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176]	0.7218584346741556	0.9043988313405984	0.36578395764539	1.0	1.0	3	Q16836,Q08426	2
+EB1, C-terminal [IPR004953]	0.7870947630922719	0.8986972643382806	0.3688139345651244	1.0	1.0	2	Q15555	1
+Putative WW-binding domain and destruction box [IPR033461]	0.7858478802992542	0.8935281562577352	0.3715744007930914	1.0	1.0	2	Q8TF05	1
+Gamma tubulin complex component protein, N-terminal [IPR041470]	0.7842892768079825	0.8870765240461077	0.3750377022559434	1.0	1.0	2	Q96CW5	1
+Gamma tubulin complex component, C-terminal [IPR040457]	0.7842892768079825	0.8870765240461077	0.3750377022559434	1.0	1.0	2	Q96CW5	1
+Extended PHD (ePHD) domain [IPR034732]	0.7172351548317022	0.8861464679691936	0.3755386057967889	1.0	1.0	3	Q8IWS0	1
+Peptidase M28 [IPR007484]	0.714998440910512	0.8773451640852694	0.3802991879707678	1.0	1.0	3	Q969V3,P02786	2
+Far upstream element-binding protein, C-terminal [IPR015096]	0.7774314214463867	0.8588223330930344	0.390438544180812	1.0	1.0	2	Q96AE4	1
+U2A'/phosphoprotein 32 family A, C-terminal [IPR003603]	0.7090866147933361	0.8541780793335733	0.3930063270020594	1.0	1.0	3	P39687	1
+Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]	0.7746259351620975	0.8473286258597847	0.3968119752270558	1.0	1.0	2	O43390	1
+ERAP1-like C-terminal domain [IPR024571]	0.5673911123344996	0.8256483086486274	0.4090036228502982	1.0	1.0	4	P55786,Q9UIQ6	2
+Acyltransferase, C-terminal domain [IPR032098]	0.7009215613040067	0.822422293975141	0.4108365953163027	1.0	1.0	3	Q9NUQ2	1
+Zinc finger C2H2 AKAP95-type [IPR034736]	0.6956517492481521	0.8020853362831654	0.4225035966778767	1.0	1.0	3	Q9ULX6	1
+SET domain [IPR001214]	0.5248845546978236	0.7995870820952038	0.4239500743365565	1.0	1.0	7	O96028	1
+Cold-shock protein, DNA-binding [IPR002059]	0.5604507734972648	0.798167478747007	0.4247733070653243	1.0	1.0	4	P67809,Q9Y2V2	2
+Cold shock domain [IPR011129]	0.5604507734972648	0.798167478747007	0.4247733070653243	1.0	1.0	4	P67809,Q9Y2V2	2
+Cold-shock (CSD) domain [IPR019844]	0.5604507734972648	0.798167478747007	0.4247733070653243	1.0	1.0	4	P67809,Q9Y2V2	2
+RBM3/CIRBP, RNA recognition motif [IPR034278]	0.7609102244389058	0.7917215040386639	0.4285230807886055	1.0	1.0	2	Q14011	1
+Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906]	0.7602867830423968	0.7892182284290136	0.4299844698024684	1.0	1.0	2	P51812	1
+Proteasome activator PA28, N-terminal domain [IPR003185]	0.6855574919155847	0.7635052188909778	0.4451621510814849	1.0	1.0	3	Q9UL46	1
+Proteasome activator PA28, C-terminal domain [IPR003186]	0.6855574919155847	0.7635052188909778	0.4451621510814849	1.0	1.0	3	Q9UL46	1
+Zinc finger, CCHC-type [IPR001878]	0.5167401579918846	0.7631512616789986	0.4453731915016052	1.0	1.0	7	Q9NUD5	1
+Aminopeptidase N-like , N-terminal domain [IPR045357]	0.5063907188515304	0.7333910690013724	0.4633199447759679	1.0	1.0	6	P55786,Q9UIQ6	2
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	0.5063907188515304	0.7333910690013724	0.4633199447759679	1.0	1.0	6	P55786,Q9UIQ6	2
+AP complex, mu/sigma subunit [IPR022775]	0.522349141854419	0.7198647009698109	0.4716083035698879	1.0	1.0	5	P48444,Q9Y2T2	2
+DNA mismatch repair protein MutS, C-terminal [IPR000432]	0.671411347978109	0.7103487675735047	0.4774878850136947	1.0	1.0	3	P20585	1
+DNA mismatch repair protein MutS-like, N-terminal [IPR007695]	0.671411347978109	0.7103487675735047	0.4774878850136947	1.0	1.0	3	P20585	1
+DNA mismatch repair protein MutS, core [IPR007696]	0.671411347978109	0.7103487675735047	0.4774878850136947	1.0	1.0	3	P20585	1
+DNA mismatch repair protein MutS, connector domain [IPR007860]	0.671411347978109	0.7103487675735047	0.4774878850136947	1.0	1.0	3	P20585	1
+Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]	0.6710321172435267	0.7089394826571641	0.4783620323315207	1.0	1.0	3	Q00839,Q9BUJ2	2
+Kinesin-like [IPR022164]	0.6636061950400467	0.6815199759047176	0.4955425312979589	1.0	1.0	3	Q12756	1
+Rap/Ran-GAP domain [IPR000331]	0.7312967581047416	0.6754766597628497	0.4993729753383422	1.0	1.0	2	Q86X10	1
+Peptidase M16, middle/third domain [IPR032632]	0.730673316708233	0.6730929402466006	0.5008881649876469	1.0	1.0	2	O43847	1
+JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]	0.4990184290182429	0.6689142612637182	0.5035501723749105	1.0	1.0	8	O15372,O95630	2
+Glutamine amidotransferase type 2 domain [IPR017932]	0.6566884939195565	0.6562919865574739	0.5116362725560069	1.0	1.0	3	Q06203,P08243	2
+4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]	0.5202744853399864	0.6439204657097658	0.5196270098933429	1.0	1.0	4	O00217,Q16134,P61221	3
+PTBP1, RNA recognition motif 2-like [IPR021790]	0.5164539123809688	0.6297652760994403	0.5288481674420389	1.0	1.0	4	Q8WVV9	1
+Phospholipid/glycerol acyltransferase [IPR002123]	0.493112907079122	0.6277637303732773	0.5301587292303123	1.0	1.0	9	Q9NUQ2,Q8NF37,Q96MH6,Q9HCL2	4
+CTP synthase GATase domain [IPR033828]	0.7185162094763129	0.6271968792902222	0.5305301886044476	1.0	1.0	2	P17812	1
+CTP synthase, N-terminal [IPR017456]	0.7185162094763129	0.6271968792902222	0.5305301886044476	1.0	1.0	2	P17812	1
+Lamin tail domain [IPR001322]	0.6412093295005097	0.6010354048620273	0.5478164051737491	1.0	1.0	3	P20700	1
+Cyclin-like [IPR013763]	0.635660132905046	0.5816584440533663	0.5607967678789278	1.0	1.0	3	P14635	1
+Ancestral coatomer element 1, Sec16/Sec31 [IPR024298]	0.7032418952618493	0.5712311214404402	0.5678429847874078	1.0	1.0	2	O15027	1
+Peptidase M41 [IPR000642]	0.6991895261845426	0.5567255354025035	0.577714967446179	1.0	1.0	2	Q9Y4W6	1
+Sec24-like, trunk domain [IPR041742]	0.6274803417354835	0.5535430439338923	0.5798916145919797	1.0	1.0	3	O95486	1
+AGC-kinase, C-terminal [IPR000961]	0.4624469864633115	0.528141113331044	0.5974013971520509	1.0	1.0	7	Q15418,P31751,P51812	3
+Oxidoreductase, N-terminal domain [IPR041694]	0.690773067331675	0.5270874135029768	0.5981328868258791	1.0	1.0	2	Q14914	1
+Potassium channel tetramerisation-type BTB domain [IPR003131]	0.6901496259351663	0.5249190152164522	0.5996394900450037	1.0	1.0	2	Q9NXV2	1
+ERM family, FERM domain C-lobe [IPR041789]	0.4862757330006144	0.5219070180523382	0.6017350716871539	1.0	1.0	4	P35240,P15311,P26038	3
+Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791]	0.6882793017456401	0.5184367079531845	0.604153608787813	1.0	1.0	2	Q9H993	1
+Ribosomal protein L7Ae/L30e/S12e/Gadd45 [IPR004038]	0.4653107099062518	0.4941522254576588	0.6211986768093203	1.0	1.0	5	P25398	1
+C2 DOCK-type domain [IPR027007]	0.6792394014962637	0.4876013204347291	0.6258322601042106	1.0	1.0	2	Q14185	1
+DOCKER domain [IPR027357]	0.6792394014962637	0.4876013204347291	0.6258322601042106	1.0	1.0	2	Q14185	1
+Agenet-like domain [IPR008395]	0.6039912690988403	0.4760388302517148	0.6340467144811532	1.0	1.0	3	Q06787,P51114	2
+Synaptic functional regulator FMRP, KH0 domain [IPR040472]	0.6039912690988403	0.4760388302517148	0.6340467144811532	1.0	1.0	3	Q06787,P51114	2
+Fragile X-related 1 protein, C-terminal core [IPR022034]	0.6039912690988403	0.4760388302517148	0.6340467144811532	1.0	1.0	3	Q06787,P51114	2
+Fxr1, tudor domain [IPR041560]	0.6039912690988403	0.4760388302517148	0.6340467144811532	1.0	1.0	3	Q06787,P51114	2
+Phox homology [IPR001683]	0.4603264572020566	0.4760016092913802	0.6340732314026154	1.0	1.0	10	O60749,Q9Y5X1,Q9UNH7,Q9Y2I1,Q96L92	5
+Tudor domain [IPR002999]	0.4509109460828654	0.4663771747361935	0.6409455466241281	1.0	1.0	8	Q14739	1
+CARG-binding factor, N-terminal [IPR012956]	0.6714463840399049	0.4617038053070803	0.644293741848901	1.0	1.0	2	Q99729	1
+Proteasome alpha-subunit, N-terminal domain [IPR000426]	0.4443510773017668	0.4541770673328943	0.649701387450079	1.0	1.0	7	P25787	1
+CD80-like, immunoglobulin C2-set [IPR013162]	0.6683291770573613	0.451529270270306	0.6516081340064483	1.0	1.0	2	Q13740	1
+FYVE zinc finger [IPR000306]	0.5927631088466812	0.440848221706857	0.6593228806859124	1.0	1.0	3	O14964	1
+Zinc finger, FYVE-related [IPR017455]	0.5927631088466812	0.440848221706857	0.6593228806859124	1.0	1.0	3	O14964	1
+BTB/POZ domain [IPR000210]	0.4485339987523337	0.3990600913493418	0.689848927411105	1.0	1.0	4	Q9P2R3,Q96CX2,Q9NXV2	3
+Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal [IPR015211]	0.6468204488778105	0.3843693879454132	0.7007046860400061	1.0	1.0	2	P09960	1
+Sorting nexin Vps5-like, C-terminal [IPR015404]	0.4410899170143867	0.37671663865877	0.7063841964591284	1.0	1.0	4	O60749	1
+ABC transporter type 1, transmembrane domain [IPR011527]	0.433988411513448	0.3729725513661009	0.7091688731684773	1.0	1.0	10	P08183,O14678,P33527,O75027	4
+Diaphanous autoregulatory (DAD) domain [IPR014767]	0.5657307052575669	0.3616691645149472	0.7175992724719784	1.0	1.0	3	Q9NSV4	1
+RBM1CTR [IPR012604]	0.6312344139650925	0.3392461336486181	0.734424318030195	1.0	1.0	2	Q96E39	1
+Rpn11/EIF3F, C-terminal [IPR024969]	0.4260761072988061	0.3337826254603859	0.7385435951407882	1.0	1.0	4	P51665,O00303,O00487	3
+Phosducin, thioredoxin-like domain [IPR024253]	0.621259351620953	0.3120343625559763	0.7550144086233637	1.0	1.0	2	Q13371	1
+Fragile X-related 1 protein, C-terminal region 1 [IPR032172]	0.6038029925187091	0.267696012800203	0.7889333191653016	1.0	1.0	2	P51114	1
+Dilute domain [IPR002710]	0.6031795511222002	0.2661917158033234	0.79009156277003	1.0	1.0	2	Q9Y4I1	1
+TOG domain [IPR034085]	0.392627170138203	0.2615814770234435	0.7936441260985012	1.0	1.0	7	O75122,Q86Y56	2
+Sec23/Sec24 beta-sandwich [IPR012990]	0.3927011852776073	0.2494763112679518	0.8029923625993423	1.0	1.0	4	P53992,O95486,O95487	3
+Zinc finger, Sec23/Sec24-type [IPR006895]	0.3927011852776073	0.2494763112679518	0.8029923625993423	1.0	1.0	4	P53992,O95486,O95487	3
+Sec23/Sec24, helical domain [IPR006900]	0.3927011852776073	0.2494763112679518	0.8029923625993423	1.0	1.0	4	P53992,O95486,O95487	3
+Sec23/Sec24, trunk domain [IPR006896]	0.3927011852776073	0.2494763112679518	0.8029923625993423	1.0	1.0	4	P53992,O95486,O95487	3
+XPC-binding domain [IPR015360]	0.5910224438902802	0.2379729784343831	0.8119020523009222	1.0	1.0	2	P54727	1
+RAD23A/RAD23B, UBA1 domain [IPR041811]	0.5910224438902802	0.2379729784343831	0.8119020523009222	1.0	1.0	2	P54727	1
+CRIB domain [IPR000095]	0.5054568132210648	0.217615226085437	0.8277289200914377	1.0	1.0	3	Q13177,Q9Y5S2	2
+SMCs flexible hinge [IPR010935]	0.3797191887675463	0.2166796289841198	0.828458024575158	1.0	1.0	5	Q9NTJ3,O95347,Q9UQE7,Q14683	4
+Glutathione S-transferase, N-terminal [IPR004045]	0.3789124357066347	0.2164588287048506	0.8286301143193309	1.0	1.0	7	P78417	1
+Dynamin, N-terminal [IPR045063]	0.3793466505570772	0.2069902481519624	0.8360174744276956	1.0	1.0	8	O60313,Q9H4M9	2
+Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]	0.3793466505570772	0.2069902481519624	0.8360174744276956	1.0	1.0	8	O60313,Q9H4M9	2
+Extended synaptotagmin, C2B domain [IPR037749]	0.5614089775561162	0.1782552681031993	0.858522507005989	1.0	1.0	2	A0FGR8	1
+Synaptotagmin, SMP domain [IPR039010]	0.5614089775561162	0.1782552681031993	0.858522507005989	1.0	1.0	2	A0FGR8	1
+Extended synaptotagmin, C2A domain [IPR037733]	0.5614089775561162	0.1782552681031993	0.858522507005989	1.0	1.0	2	A0FGR8	1
+Extended synaptotagmin, C-terminal C2 domain [IPR037752]	0.5614089775561162	0.1782552681031993	0.858522507005989	1.0	1.0	2	A0FGR8	1
+Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468]	0.5614089775561162	0.1782552681031993	0.858522507005989	1.0	1.0	2	A0FGR8	1
+Serine/threonine-protein kinase OSR1/WNK, CCT domain [IPR024678]	0.5573566084788095	0.1710835070948787	0.8641581041052468	1.0	1.0	2	O95747	1
+E3 ligase, CCCH-type zinc finger [IPR041367]	0.3468029100586414	0.1610593724617982	0.8720466385018346	1.0	1.0	4	Q9UPT8	1
+Glutamine amidotransferase [IPR017926]	0.3451957716275649	0.1585590993958247	0.8740162549942323	1.0	1.0	4	P17812	1
+Rhodanese-like domain [IPR001763]	0.3390517779164109	0.1493679225189163	0.8812633218711659	1.0	1.0	4	Q8NCN5,Q99956,P25325	3
+GOLD domain [IPR009038]	0.3519853442540808	0.1462317489360579	0.8837384429199002	1.0	1.0	6	Q9Y3B3	1
+Alpha-D-phosphohexomutase, alpha/beta/alpha domain I [IPR005844]	0.5358478802992588	0.1369859408420218	0.8910419079282832	1.0	1.0	2	Q96G03	1
+Alpha-D-phosphohexomutase, alpha/beta/alpha domain II [IPR005845]	0.5358478802992588	0.1369859408420218	0.8910419079282832	1.0	1.0	2	Q96G03	1
+Alpha-D-phosphohexomutase, alpha/beta/alpha domain III [IPR005846]	0.5358478802992588	0.1369859408420218	0.8910419079282832	1.0	1.0	2	Q96G03	1
+DNA2/NAM7 helicase-like, C-terminal [IPR041679]	0.3435257410296353	0.1319416886359283	0.8950304140916865	1.0	1.0	5	P42694,Q9HCE1,P51530,Q92900	4
+SGNH hydrolase-type esterase domain [IPR013830]	0.4522649820657756	0.1315920291657276	0.8953069905012436	1.0	1.0	3	P68402	1
+Ran binding domain [IPR000156]	0.3222083593262675	0.127100734735898	0.8988606699444106	1.0	1.0	4	P49792,P43487,Q9H6Z4	3
+ABC transporter-like, ATP-binding domain [IPR003439]	0.3719254865922355	0.1262262989722835	0.8995527942899284	1.0	1.0	14	P08183,O14678,P61221,O75027,P33527	5
+Sec63 domain [IPR004179]	0.447458684128469	0.1256992494166509	0.8999699960339014	1.0	1.0	3	Q9UGP8,Q8N3C0	2
+Morc, S5 domain 2-like [IPR041006]	0.5246259351621019	0.1217792390068846	0.9030738564304202	1.0	1.0	2	Q9Y6X9	1
+Domain of unknown function DUF4749 [IPR031847]	0.5233790523690844	0.1201954408805585	0.90432832924457	1.0	1.0	2	Q96HC4	1
+Heat shock protein DnaJ, cysteine-rich domain [IPR001305]	0.4408131716341026	0.1180369514666644	0.9060383794902244	1.0	1.0	3	O60884	1
+Copine, C-terminal [IPR010734]	0.4356096039912667	0.1124218436731433	0.9104889363682068	1.0	1.0	3	O75131,Q86YQ8	2
+Copine, C2B domain [IPR037768]	0.4356096039912667	0.1124218436731433	0.9104889363682068	1.0	1.0	3	O75131,Q86YQ8	2
+Exportin-2, central domain [IPR013713]	0.4324914250077979	0.1092153580417183	0.9130316792207148	1.0	1.0	3	P55060,O95373	2
+DALR anticodon binding [IPR008909]	0.5130922693266906	0.1079138867713958	0.9140640014024266	1.0	1.0	2	P54136	1
+Arginyl-tRNA synthetase, catalytic core domain [IPR035684]	0.5130922693266906	0.1079138867713958	0.9140640014024266	1.0	1.0	2	P54136	1
+Laminin-type EGF domain [IPR002049]	0.5062344139650947	0.100483139465247	0.9199607678434965	1.0	1.0	2	P07942	1
+Laminin, N-terminal [IPR008211]	0.5062344139650947	0.100483139465247	0.9199607678434965	1.0	1.0	2	P07942	1
+p21 activated kinase binding domain [IPR033923]	0.5052992518703298	0.0995154193969822	0.9207290457618622	1.0	1.0	2	Q13177	1
+CYRIA/CYRIB, Rac1 binding domain [IPR009828]	0.4211737987757048	0.0985416128868125	0.921502230426708	1.0	1.0	3	Q9NUQ9	1
+Methylglyoxal synthase-like domain [IPR011607]	0.5024937655860424	0.0966766492344407	0.9229831841622608	1.0	1.0	2	P27708	1
+Anticodon-binding [IPR004154]	0.2782283218964507	0.087463522518683	0.9303030790940944	1.0	1.0	4	P07814,Q9BW92,P26639	3
+Peptidase M24 [IPR000994]	0.3286105586684794	0.0781767996641303	0.9376874167119288	1.0	1.0	7	Q9NQH7,P53582	2
+NUC153 [IPR012580]	0.4809850374064916	0.077964158114574	0.9378565638588297	1.0	1.0	2	Q9H501	1
+Peptidyl-prolyl cis-trans isomerase, PpiC-type [IPR000297]	0.4794264339152182	0.0768062439136624	0.9387776834895896	1.0	1.0	2	Q13526	1
+S-adenosyl-L-homocysteine hydrolase, NAD binding domain [IPR015878]	0.4750623441396589	0.0736970869958681	0.9412514167281432	1.0	1.0	2	O43865	1
+Armadillo repeat-containing domain [IPR006911]	0.3851260779121475	0.0736208021237422	0.9413121183536676	1.0	1.0	3	Q96D09	1
+PTB/PI domain [IPR006020]	0.3085803432137238	0.0716270536247275	0.942898709687638	1.0	1.0	5	Q9UKG1,O60343,Q9Y3P9,Q5SW96	4
+Methyltransferase type 11 [IPR013216]	0.468204488778063	0.0691936883130328	0.9448354470646232	1.0	1.0	2	Q8N6R0	1
+EF-hand domain [IPR002048]	0.442534771029704	0.0638616956509768	0.9490803524338148	1.0	1.0	43	O43707,P31949,P80303,Q9BPX6,O75071,O43149,Q9NWM8,Q02818,Q9Y680,Q8IYU8,Q8NF37,P07384,Q14257,Q9BRK5,O43852,Q9H4M9	16
+MPN domain [IPR037518]	0.3353415071854915	0.0624163608533665	0.9502312662859004	1.0	1.0	11	O15372,O95630	2
+ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]	0.4538653366583609	0.0611783246020206	0.9512171918539428	1.0	1.0	2	Q9NVI7	1
+Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2 [IPR034798]	0.4445137157107311	0.0568752461502052	0.9546445730963876	1.0	1.0	2	Q9UKA9	1
+Ubiquitin-activating enzyme E1, four-helix bundle [IPR032420]	0.443890274314223	0.0566121545691259	0.9548541521283952	1.0	1.0	2	A0AVT1	1
+Ubiquitin-activating enzyme E1, FCCH domain [IPR032418]	0.443890274314223	0.0566121545691259	0.9548541521283952	1.0	1.0	2	A0AVT1	1
+Ubiquitin-activating enzyme E1, C-terminal [IPR018965]	0.443890274314223	0.0566121545691259	0.9548541521283952	1.0	1.0	2	A0AVT1	1
+Ubiquitin-activating enzyme, SCCH domain [IPR019572]	0.443890274314223	0.0566121545691259	0.9548541521283952	1.0	1.0	2	A0AVT1	1
+RasGAP protein, C-terminal [IPR000593]	0.3314624259432489	0.0556915368467772	0.955587541658226	1.0	1.0	3	P46940,Q86VI3	2
+Pre-SET domain [IPR007728]	0.435162094763101	0.0532193242331148	0.9575571589212646	1.0	1.0	2	Q15047	1
+DDHD domain [IPR004177]	0.4317331670823031	0.0520273019523213	0.9585069390564532	1.0	1.0	2	Q9Y6Y8	1
+Desmoplakin, SH3 domain [IPR041615]	0.2818833801060229	0.0504265938231972	0.95978244453374	1.0	1.0	3	P15924,Q15149	2
+Desmoplakin, spectrin-like domain [IPR041573]	0.2818833801060229	0.0504265938231972	0.95978244453374	1.0	1.0	3	P15924,Q15149	2
+Patatin-like phospholipase domain [IPR002641]	0.4092892768079866	0.0459151956849174	0.9633778425457448	1.0	1.0	2	Q9NP80	1
+ATPase, dynein-related, AAA domain [IPR011704]	0.4052369077306798	0.0450827092345228	0.9640413834407318	1.0	1.0	2	A3KMH1	1
+Domain of unknown function DUF1747 [IPR013719]	0.3958852867830505	0.0434237417244765	0.9653637523889708	1.0	1.0	2	Q9Y5B9	1
+ATP:guanido phosphotransferase, N-terminal [IPR022413]	0.3809226932668401	0.0414180494090254	0.9669626237955988	1.0	1.0	2	P12277	1
+ATP:guanido phosphotransferase, catalytic domain [IPR022414]	0.3809226932668401	0.0414180494090254	0.9669626237955988	1.0	1.0	2	P12277	1
+rRNA-processing arch domain [IPR025696]	0.3746882793017554	0.0407777490675884	0.9674730782731816	1.0	1.0	2	Q15477	1
+ATP-dependent RNA helicase Ski2, C-terminal [IPR012961]	0.3746882793017554	0.0407777490675884	0.9674730782731816	1.0	1.0	2	Q15477	1
+Ku70/Ku80 beta-barrel domain [IPR006164]	0.360037406483798	0.0396297308150207	0.9683883242885384	1.0	1.0	2	P12956	1
+Ku70/Ku80, N-terminal alpha/beta [IPR005161]	0.360037406483798	0.0396297308150207	0.9683883242885384	1.0	1.0	2	P12956	1
+Ku70/Ku80 C-terminal arm [IPR005160]	0.360037406483798	0.0396297308150207	0.9683883242885384	1.0	1.0	2	P12956	1
+SUI1 domain [IPR001950]	0.3575436408977631	0.0394764882724324	0.9685104985421586	1.0	1.0	2	O43583	1
+Thioredoxin-like fold [IPR012336]	0.3531795511222022	0.039233369894895	0.9687043287802825	1.0	1.0	2	Q6DKJ4	1
+GRAM domain [IPR004182]	0.3456982543640974	0.0388829521666141	0.9689837084903328	1.0	1.0	2	Q66K14	1
+Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain [IPR020059]	0.3394638403990113	0.0386462342565547	0.9691724401993356	1.0	1.0	2	P07814	1
+USP8 dimerisation domain [IPR015063]	0.3388403990025015	0.0386250090565196	0.9691893628237328	1.0	1.0	2	O95630	1
+Threonine-tRNA ligase catalytic core domain [IPR033728]	0.3304239401496338	0.0383765905890109	0.9693874252335524	1.0	1.0	2	Q9BW92	1
+MAGE homology domain [IPR002190]	0.28366583541148	0.0377967384964363	0.9698497448186504	1.0	1.0	2	Q9UNF1	1
+TGS [IPR004095]	0.2936953807740308	0.0161151430569152	0.9871425326715728	1.0	1.0	6	P26639,Q9NTK5,Q9BW92,Q9NYK5,P55039	5
+High mobility group box domain [IPR009071]	0.3111043373029241	0.0093869000956632	0.992510447328974	1.0	1.0	12	O96028,P09429	2

interpro_family/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome B-type subunit [IPR023333]"}

interpro_family/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome B-type subunit [IPR023333]", "1": "Proteasome, subunit alpha/beta [IPR001353]"}

interpro_family/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:2341d9e2067fdfea12d25c4ce9934701aefc3763f3ee1345205313debbc79423
+size 72921

interpro_family/df_merge.tsv

@@ -0,0 +1,3 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Proteasome B-type subunit [IPR023333]	5	7	2.1441465841449774	0.03202114348155	3.699029126213592	6.970873786407767	1.6670727234653664	0.1509307531330224	1.4503762582219135	0.1681602725795027	0.9611878160538336	0.233503072382129	1.0	1.0	0.0832836732680532	3.788095303003865e-05	2.80346154767832e-05
+Protein arginine N-methyltransferase [IPR025799]	0	5	2.10907350255614	0.0349382376244267	2.0825242718446604	4.550970873786408	0.3373673127581389	0.5030561866515755	1.3997175293723505	0.5070608522549612	0.967000381893454	0.3222502577912521	1.0	1.0	1.0	0.1775366954381628	0.3279667038186614

interpro_family/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3210,
+    "annotations_size": 2482,
+    "title": "Average number of proteins per term",
+    "value": 1.2723609991941982
+}

interpro_family/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_family/fragment/C405/C405_val_log2fc"}

interpro_family/result.tsv

@@ -0,0 +1,110 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Eukaryotic porin/Tom40 [IPR027246]	0.959777160342176	2.4315716919846735	0.0150334728448213	1.0	0.7237134984612155	4	P21796	1
+Proteasome B-type subunit [IPR023333]	0.8238072517814038	2.1441465841449774	0.03202114348155	1.0	0.7237134984612155	7	P28072,P20618,P28074,P28070,P49721	5
+Peptidase S10, serine carboxypeptidase [IPR001563]	0.9887745556594952	2.0056771528537403	0.0448907043521709	1.0	0.7237134984612155	3	Q9H3G5,Q9HB40	2
+Transmembrane protein GPR107/GPR108-like [IPR009637]	0.9766136576239476	1.955755890285596	0.0504939173144767	1.0	0.7237134984612155	3	Q9NPR9,Q5VW38	2
+Nucleosome assembly protein (NAP) [IPR002164]	0.8340611353711885	1.930151706457432	0.0535880433400177	1.0	0.7237134984612155	4	P55209,Q99733,Q01105	3
+Porin, eukaryotic type [IPR001925]	0.9598450563683528	1.886684161828676	0.0592028191921194	1.0	0.7237134984612155	3	P21796	1
+Nucleobindin [IPR040250]	0.9962593516209476	1.812455110807097	0.0699159039951191	1.0	0.7237134984612155	2	P80303	1
+CD36 family [IPR002159]	0.9887780548628428	1.7793622570471304	0.0751803901269467	1.0	0.7237134984612155	2	Q8WTV0	1
+Mini-chromosome maintenance protein [IPR031327]	0.7190506064647937	1.7028781264444324	0.0885908782433086	1.0	0.7237134984612155	6	Q14566	1
+Amyloidogenic glycoprotein [IPR008155]	0.969139650872818	1.6923774337489452	0.0905740321898784	1.0	0.7237134984612155	2	P05067	1
+Mitochondrial carrier UCP-like [IPR002030]	0.9678927680798012	1.68685021885262	0.0916321562870035	1.0	0.7237134984612155	2	Q9H2D1	1
+Cytochrome P450 [IPR001128]	0.9619700748129678	1.6605909896174815	0.0967956198410702	1.0	0.7237134984612155	2	Q6UW02	1
+Haem oxygenase [IPR002051]	0.960099750623442	1.6522971655650085	0.0984739868496693	1.0	0.7237134984612155	2	P30519	1
+Haem oxygenase-like [IPR016053]	0.960099750623442	1.6522971655650085	0.0984739868496693	1.0	0.7237134984612155	2	P30519	1
+V-type  ATPase, V0 complex, 116kDa subunit family [IPR002490]	0.9538653366583548	1.6246475858796303	0.1042376715144306	1.0	0.7237134984612155	2	Q93050	1
+ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028]	0.9538653366583548	1.6246475858796303	0.1042376715144306	1.0	0.7237134984612155	2	Q93050	1
+Cleft lip and palate transmembrane protein 1-like protein [IPR030434]	0.9532418952618458	1.621882412034661	0.104828528100749	1.0	0.7237134984612155	2	O96005	1
+Cleft lip and palate transmembrane 1 [IPR008429]	0.9532418952618458	1.621882412034661	0.104828528100749	1.0	0.7237134984612155	2	O96005	1
+Histidine phosphatase superfamily, clade-2 [IPR000560]	0.8910990541763126	1.60127738289737	0.1093154961090103	1.0	0.7237134984612155	3	Q9NPH0	1
+Calcium uptake protein 1/2/3 [IPR039800]	0.9360972568578556	1.5458413449760295	0.1221428891056073	1.0	0.7237134984612155	2	Q9BPX6	1
+Peptidase T1A, proteasome beta-subunit [IPR000243]	0.8732197009415291	1.5266856169299083	0.1268392056423368	1.0	0.7237134984612155	3	P28072	1
+Proteasome, subunit alpha/beta [IPR001353]	0.707139706231984	1.5074030962573788	0.1317073656301941	1.0	0.7237134984612155	14	P49720,P28070,P28072,P20618,P28074,P25787,P49721	7
+P-type ATPase [IPR001757]	0.6641141274093088	1.4542472722511142	0.1458777632243908	1.0	0.7237134984612155	6	P20020,Q9HD20,P23634	3
+Nonaspanin (TM9SF) [IPR004240]	0.8887157107231937	1.3362287938591195	0.1814745023704023	1.0	0.7420554279369538	2	Q9HD45	1
+Sulfotransferase [IPR005331]	0.8765586034912732	1.2827449439442105	0.1995814484053482	1.0	0.7476724784887091	2	Q8NCH0	1
+Major facilitator superfamily [IPR011701]	0.6655483032280893	1.228969234163234	0.219083341319644	1.0	0.7662010966005843	4	Q7L0J3	1
+TAF15/EWS/TLS family [IPR034870]	0.7907701902089213	1.183726477737628	0.2365213542008302	1.0	0.7857222349537532	3	P35637,Q01844	2
+Prenylated rab acceptor PRA1 [IPR004895]	0.8534912718204501	1.1818487582157655	0.2372657171349623	1.0	0.7857222349537532	2	O60831	1
+Endoplasmic reticulum vesicle transporter [IPR045888]	0.8469451371571092	1.1533915858177946	0.2487496935326731	1.0	0.7984972470103028	2	Q9Y282	1
+Acidic leucine-rich nuclear phosphoprotein 32 [IPR045081]	0.7789113340528806	1.1349155992470732	0.2564106832973281	1.0	0.8059865225312282	3	P39687	1
+Peptidase S9A, prolyl oligopeptidase [IPR002470]	0.8413341645885304	1.1290730417782722	0.258867022470292	1.0	0.8070584839892975	2	Q4J6C6	1
+Translation initiation factor IF2/IF5 [IPR045196]	0.830735660847882	1.0833430538527336	0.2786561818856059	1.0	0.8195996640417742	2	P55010	1
+Clathrin adaptor, mu subunit [IPR001392]	0.7659487901180455	1.0818434485182078	0.2793220967504939	1.0	0.8195996640417742	3	Q9BXS5	1
+P-type ATPase, subfamily IIB [IPR006408]	0.8257481296758122	1.061924856174166	0.2882697999662005	1.0	0.8242922160323843	2	P23634	1
+Initiation factor 2B-related [IPR000649]	0.7608284331064028	1.0609733365172267	0.2887020187506315	1.0	0.824578147916073	3	P49770	1
+Peroxisomal acyl-coenzyme A oxidase [IPR034171]	0.8201371571072338	1.03791448086461	0.299309871179813	1.0	0.8272684858221557	2	O15254	1
+Acyl-CoA oxidase [IPR012258]	0.8201371571072338	1.03791448086461	0.299309871179813	1.0	0.8272684858221557	2	O15254	1
+Tropomyosin [IPR000533]	0.7460079651111424	1.0009158703380323	0.3168674832138816	1.0	0.8433805882298161	3	P06753	1
+Oligosaccharyl transferase, STT3 subunit [IPR003674]	0.80985037406484	0.9941501055917022	0.3201497947364895	1.0	0.8453316920595393	2	Q8TCJ2	1
+Ergosterol biosynthesis ERG4/ERG24 [IPR001171]	0.8064214463840429	0.9796409247435216	0.3272633962034301	1.0	0.8559196516089712	2	Q14739	1
+Basigin-like [IPR043204]	0.7936408977556133	0.9259453105871094	0.3544744023241819	1.0	0.869372990680454	2	P35613	1
+Ribosomal protein L15 [IPR030878]	0.7927057356608503	0.9220416596382516	0.356506845959188	1.0	0.8709153461325833	2	P46776	1
+Ribosomal protein S11 [IPR001971]	0.7877182044887805	0.901284389102996	0.3674371317922951	1.0	0.882845073677131	2	P82912	1
+Microtubule-associated protein RP/EB [IPR027328]	0.7870947630922719	0.8986972643382806	0.3688139345651244	1.0	0.8835870517284159	2	Q15555	1
+Gamma-tubulin complex component protein [IPR007259]	0.7842892768079825	0.8870765240461077	0.3750377022559434	1.0	0.8890578576879195	2	Q96CW5	1
+MICOS complex subunit MIC26/MIC27, animal [IPR033182]	0.777743142144641	0.8601017850597797	0.3897329373198115	1.0	0.8998584790182198	2	Q9BUR5	1
+MICOS complex subunit MIC26/MIC27 [IPR019166]	0.777743142144641	0.8601017850597797	0.3897329373198115	1.0	0.8998584790182198	2	Q9BUR5	1
+HnRNP R/Q splicing factor [IPR006535]	0.7746259351620975	0.8473286258597847	0.3968119752270558	1.0	0.9086746756700548	2	O43390	1
+SCAMP [IPR007273]	0.77337905236908	0.8422328286560239	0.3996576414722896	1.0	0.909576710702435	2	O15127	1
+Aminopeptidase N-type [IPR034016]	0.5673911123344996	0.8256483086486274	0.4090036228502982	1.0	0.9129019711460792	4	P55786,Q9UIQ6	2
+Luc7-related [IPR004882]	0.7668329177057385	0.8156106340581434	0.4147228654540817	1.0	0.9182488885316724	2	Q9Y383	1
+A-kinase anchoring protein 95 (AKAP95) [IPR007071]	0.6956517492481521	0.8020853362831654	0.4225035966778767	1.0	0.9236247438810904	3	Q9ULX6	1
+Ribosomal protein S6 kinase II [IPR016239]	0.7602867830423968	0.7892182284290136	0.4299844698024684	1.0	0.9292655357967616	2	P51812	1
+Derlin [IPR007599]	0.7577930174563624	0.7792273838579834	0.4358457818184347	1.0	0.9292655357967616	2	Q9GZP9	1
+Proteasome activator PA28 [IPR009077]	0.6855574919155847	0.7635052188909778	0.4451621510814849	1.0	0.9329771275388355	3	Q9UL46	1
+Translin family [IPR002848]	0.747194513715714	0.7371802604193787	0.4610127358926905	1.0	0.9444153140619864	2	Q99598	1
+Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930]	0.5063907188515304	0.7333910690013724	0.4633199447759679	1.0	0.9451274843562416	6	P55786,Q9UIQ6	2
+DNA mismatch repair MutS family [IPR045076]	0.671411347978109	0.7103487675735047	0.4774878850136947	1.0	0.9511520090753944	3	P20585	1
+HnRNP-L/PTB [IPR006536]	0.5164539123809688	0.6297652760994403	0.5288481674420389	1.0	0.98720809014792	4	Q8WVV9	1
+CTP synthase [IPR004468]	0.7185162094763129	0.6271968792902222	0.5305301886044476	1.0	0.9878069375243064	2	P17812	1
+UBAP2/protein lingerer [IPR022166]	0.7069825436409015	0.5847518082671811	0.5587146126694671	1.0	0.9991004437212392	2	Q5T6F2	1
+Purine 5'-nucleotidase [IPR016695]	0.7054239401496298	0.5791031335533965	0.5625195858054559	1.0	0.9991004437212392	2	Q9H857	1
+DnaJ homolog subfamily A member 1/2-like [IPR044713]	0.7041770573566122	0.5745996455153218	0.5655620918628099	1.0	0.9991004437212392	2	O60884	1
+Peptidase, FtsH [IPR005936]	0.6991895261845426	0.5567255354025035	0.577714967446179	1.0	0.9991004437212392	2	Q9Y4W6	1
+Transport protein particle (TRAPP) component [IPR007194]	0.6945137157107273	0.5401768541332322	0.5890750732782144	1.0	0.9991004437212392	2	Q8IUR0	1
+Medium-chain dehydrogenase/reductase [IPR045010]	0.690773067331675	0.5270874135029768	0.5981328868258791	1.0	0.9991004437212392	2	Q14914	1
+Phosphatidyl serine synthase [IPR004277]	0.6895261845386575	0.5227544214759184	0.6011451611971828	1.0	0.9991004437212392	2	P48651	1
+Ezrin/radixin/moesin [IPR011174]	0.4862757330006144	0.5219070180523382	0.6017350716871539	1.0	0.9991004437212392	4	P35240,P15311,P26038	3
+Kinesin light chain [IPR002151]	0.6889027431421488	0.5205936473618699	0.6026498756536682	1.0	0.9991004437212392	2	Q07866	1
+Dedicator of cytokinesis [IPR026791]	0.6792394014962637	0.4876013204347291	0.6258322601042106	1.0	0.9991004437212392	2	Q14185	1
+Fragile X mental retardation syndrome-related protein [IPR040148]	0.6039912690988403	0.4760388302517148	0.6340467144811532	1.0	0.9991004437212392	3	Q06787,P51114	2
+Proteasome alpha-type subunit [IPR023332]	0.4443510773017668	0.4541770673328943	0.649701387450079	1.0	0.9991004437212392	7	P25787	1
+Aminopeptidase, leukotriene A4 hydrolase-like [IPR034015]	0.6468204488778105	0.3843693879454132	0.7007046860400061	1.0	0.9991004437212392	2	P09960	1
+TB2/DP1/HVA22-related protein [IPR004345]	0.4235766888620905	0.3471440584851845	0.7284830952734185	1.0	0.9991004437212392	5	Q96HR9,Q6NUK4	2
+GrpE nucleotide exchange factor [IPR000740]	0.6327930174563643	0.3436175383003446	0.731133933347704	1.0	0.9991004437212392	2	Q8TAA5	1
+Tricarboxylate/iron carrier [IPR004686]	0.5413358721559239	0.2976400338506446	0.765977916004192	1.0	0.9991004437212392	3	Q96NB2	1
+Transmembrane emp24 domain-containing protein [IPR015720]	0.4012198853289368	0.2771365793927367	0.7816752351157152	1.0	0.9991004437212392	5	Q9Y3B3	1
+Polyprenyl synthetase [IPR000092]	0.6069201995012525	0.2753003560018773	0.7830854909828999	1.0	0.9991004437212392	2	O95749	1
+Structural maintenance of chromosomes protein [IPR024704]	0.402370555208986	0.272239772354248	0.7854376623665633	1.0	0.9991004437212392	4	Q9NTJ3,O95347,Q9UQE7	3
+E3 ubiquitin ligase Bre1 [IPR013956]	0.5925810473815522	0.2414714880989632	0.8091897119514102	1.0	0.9991004437212392	2	Q5VTR2	1
+UV excision repair protein Rad23 [IPR004806]	0.5910224438902802	0.2379729784343831	0.8119020523009222	1.0	0.9991004437212392	2	P54727	1
+Dynein light chain, type 1/2 [IPR001372]	0.5863466334164649	0.2276895499574253	0.8198875970036295	1.0	0.9991004437212392	2	P63167	1
+Tumour protein D52 [IPR007327]	0.5511221945137224	0.1605166380517362	0.8724741162895437	1.0	0.9991004437212392	2	P55327	1
+Alpha-D-phosphohexomutase superfamily [IPR005841]	0.5358478802992588	0.1369859408420218	0.8910419079282832	1.0	0.9991004437212392	2	Q96G03	1
+DNA2/NAM7-like helicase [IPR045055]	0.3435257410296353	0.1319416886359283	0.8950304140916865	1.0	0.9991004437212392	5	P42694,Q9HCE1,P51530,Q92900	4
+Ran binding protein RanBP1-like [IPR045255]	0.3222083593262675	0.127100734735898	0.8988606699444106	1.0	0.9991004437212392	4	P49792,P43487,Q9H6Z4	3
+Ribosomal protein L24e-related [IPR000988]	0.5271197007481367	0.1250096917821756	0.9005158775991444	1.0	0.9991004437212392	2	P83731	1
+Ubiquitin/SUMO-activating enzyme E1 [IPR000011]	0.4440286872466399	0.1216748368178388	0.9031565424513404	1.0	0.9991004437212392	3	A0AVT1,Q9UBE0	2
+Chaperone DnaJ [IPR012724]	0.4408131716341026	0.1180369514666644	0.9060383794902244	1.0	0.9991004437212392	3	O60884	1
+Copine [IPR045052]	0.4356096039912667	0.1124218436731433	0.9104889363682068	1.0	0.9991004437212392	3	O75131,Q86YQ8	2
+Arginine-tRNA ligase [IPR001278]	0.5130922693266906	0.1079138867713958	0.9140640014024266	1.0	0.9991004437212392	2	P54136	1
+Adaptor protein complex, sigma subunit [IPR016635]	0.50311720698255	0.0972991880987855	0.9224888007460847	1.0	0.9991004437212392	2	Q92572	1
+Dephospho-CoA kinase [IPR001977]	0.4869077306733244	0.0825993437728663	0.934170123086966	1.0	0.9991004437212392	2	Q8WVC6	1
+Adenosylhomocysteinase-like [IPR000043]	0.4750623441396589	0.0736970869958681	0.9412514167281432	1.0	0.9991004437212392	2	O43865	1
+ATPase family AAA domain-containing protein 3 [IPR039188]	0.4538653366583609	0.0611783246020206	0.9512171918539428	1.0	0.9991004437212392	2	Q9NVI7	1
+Sister chromatid cohesion protein Pds5 [IPR039776]	0.4498129675810531	0.0592297242595484	0.9527691346598248	1.0	0.9991004437212392	2	Q29RF7	1
+Sodium/potassium-transporting ATPase subunit beta [IPR000402]	0.4466957605985122	0.0578188492200258	0.9538929237885064	1.0	0.9991004437212392	2	P54709	1
+Ubiquitin-activating enzyme E1 [IPR018075]	0.443890274314223	0.0566121545691259	0.9548541521283952	1.0	0.9991004437212392	2	A0AVT1	1
+Beta-catenin [IPR013284]	0.4024314214463925	0.0445480483990253	0.964467552883388	1.0	0.9991004437212392	2	P14923	1
+Glycosyl transferase, family 35 [IPR000811]	0.3993142144638471	0.0439918543154196	0.964910896897734	1.0	0.9991004437212392	2	P06737	1
+Glycogen/starch/alpha-glucan phosphorylase [IPR011833]	0.3993142144638471	0.0439918543154196	0.964910896897734	1.0	0.9991004437212392	2	P06737	1
+NDUFAF3/Mth938 domain-containing protein [IPR007523]	0.3893391521197095	0.0424570881348932	0.9661343195897588	1.0	0.9991004437212392	2	Q9H7C9	1
+ATP:guanido phosphotransferase [IPR000749]	0.3809226932668401	0.0414180494090254	0.9669626237955988	1.0	0.9991004437212392	2	P12277	1
+Mitogen-activated protein (MAP) kinase, ERK1/2 [IPR008349]	0.379987531172077	0.0413154077327746	0.9670444499636548	1.0	0.9991004437212392	2	P28482	1
+ATP-dependent RNA helicase Ski2-like [IPR016438]	0.3746882793017554	0.0407777490675884	0.9674730782731816	1.0	0.9991004437212392	2	Q15477	1
+THRAP3/BCLAF1 family [IPR029199]	0.348815461346641	0.039019471362327	0.9688748645320888	1.0	0.9991004437212392	2	Q9Y2W1	1
+Threonine-tRNA ligase, class IIa [IPR002320]	0.3304239401496338	0.0383765905890109	0.9693874252335524	1.0	0.9991004437212392	2	Q9BW92	1
+Histidine phosphatase superfamily, clade-1 [IPR013078]	0.2877182044887866	0.0378157617981006	0.96983457726342	1.0	0.9991004437212392	2	Q9NQ88	1
+Melanoma-associated antigen [IPR037445]	0.28366583541148	0.0377967384964363	0.9698497448186504	1.0	0.9991004437212392	2	Q9UNF1	1