Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size Slc mediated transmembrane transport 0.652048078089647 2.8225435231422793 0.0047644354621674 0.9987459467444204 0.2848703708057432 20 Q8TB61,O00400,P53985,Q9UBX3,Q70HW3,Q99808 6 Circadian clock 0.7347791060179708 2.7298324422873605 0.0063366523417296 0.999862678131502 0.2848703708057432 13 P43490,Q9BWF3,P62136,O75376,Q86X55 5 Protein localization 0.4209946136381969 2.507791720884931 0.0121488253327117 0.9999999625512492 0.3219907154880079 73 Q99595,Q5JRX3,P51648,Q9NS69,Q9NR77,P09601,O43681,Q10713,Q9Y584,P40855,Q08426,P21796,P46379,O15254,Q15067 15 Biological oxidations 0.4628999773232393 2.297344565219781 0.0215991214147506 0.999999999999946 0.4120054580205153 43 Q96DG6,Q8TB61,Q9NUJ1,O00170,O43169,P21266,P10768,Q16850,P21964,P16435,Q15185,P07099 12 Sphingolipid de novo biosynthesis 0.7063744734770482 2.2931226528091933 0.0218409445564335 0.9999999999999616 0.4120054580205153 11 O95470,P51648,O15121,Q96G23,Q06136 5 Mitophagy 0.7027337069871971 2.273916662621281 0.0229709976594711 0.9999999999999925 0.4120054580205153 11 Q9NS69,Q8N4H5,P21796,P67870,O94826,Q13501 6 Mitochondrial protein import 0.4833878329297953 2.14085311947315 0.0322858847077254 1.0 0.4911143897591645 33 Q99595,Q9Y584,Q9NS69 3 Metabolism of porphyrins 0.6773448244094097 2.138872458233408 0.0324459991593586 1.0 0.4911143897591645 11 P22830,P09601,P30519,P33527 4 Initiation of nuclear envelope ne reformation 0.5677984718936562 2.1090861392997735 0.0349371470456605 1.0 0.5091361324674905 18 Q86Y07,P50402,Q8IXJ6,P42166,Q14739,O95067,Q86XL3 7 Selective autophagy 0.5051437723233397 2.1043117119932173 0.035351265080372 1.0 0.5098599984272211 27 Q9NS69,Q8N4H5,P21796,P67870,O94826,Q13501,Q8IWA4,P63167 8 Proton coupled monocarboxylate transport 0.9407730673316708 2.05686349414881 0.0396993583939766 1.0 0.549895073199736 2 P53985 1 Pink1 prkn mediated mitophagy 0.6980568292195982 1.9964298466088637 0.0458871547562647 1.0 0.5843575675112274 9 Q9NS69,Q8N4H5,P21796,O94826,Q13501 5 Pyruvate metabolism 0.6061432494595305 1.995910065516227 0.0459437128988571 1.0 0.5843575675112274 13 Q8NCN5,P53985,P21796 3 Sphingolipid metabolism 0.4866909556028573 1.9933560441514315 0.0462224734983045 1.0 0.5843575675112274 28 O95470,P51648,P27544,O43681,Q96G23,Q16739,P04062,O15121,Q13510,Q06136 10 Tnfr1 induced nfkappab signaling pathway 0.7250806222392197 1.8797516644627608 0.0601419307620822 1.0 0.6481780067393449 7 P63244 1 Vitamin d calciferol metabolism 0.896820448877806 1.861899516368115 0.062617255245216 1.0 0.6537423302029021 2 P38435 1 Cholesterol biosynthesis 0.5293200134268284 1.845795706662892 0.0649218742349238 1.0 0.6547544173519264 18 Q15392,Q14534,O75845,Q16850,Q15800,Q14739 6 Transport of inorganic cations anions and amino acids oligopeptides 0.6679839403230745 1.84473567898765 0.0650759980567037 1.0 0.6547544173519264 9 Q9UBX3 1 Srp dependent cotranslational protein targeting to membrane 0.3404247381739372 1.8398151632347663 0.0657953784888303 1.0 0.6547544173519264 93 P18077,P61927,Q15629,P67812,P27635,P46778,P62910,P61254,P62753,P25398,P09132,P46782,P39023,P46776,P62266,P62273,P62263,P43307,P15880,Q9Y3U8,P84098,P62917,P83881,P61513,Q9Y5M8 25 Respiratory electron transport 0.3793083278499508 1.829361652105762 0.0673454483802424 1.0 0.6547544173519264 53 Q9P0J0,P31930,Q9Y6M9,P14854,O43676,Q9UDW1,O14949,Q86Y39,P20674,P13073,P00403,P03886,O95298,O75306,P31040,P51970 16 Heme signaling 0.7074302361233578 1.796999491481556 0.0723357004897489 1.0 0.6597615598193363 7 P09601,Q86X55 2 Nr1h2 and nr1h3 mediated signaling 0.7055817103799977 1.7882987607938987 0.0737278196948549 1.0 0.6597615598193363 7 Q9HCE1,O00767 2 Activation of the pre replicative complex 0.4712364691401446 1.7631938751284706 0.0778677964504777 1.0 0.6831143980465095 25 Q9UBD5,Q14181,P27694,P56282,P49642,Q7L590,Q14566,Q9Y619,P15927,O00311 10 Heme degradation 0.8237606808224105 1.7616643696274032 0.0781260212204728 1.0 0.6831143980465095 5 P09601,P30519 2 Abc family proteins mediated transport 0.3720820202681322 1.745736047125614 0.0808568282777797 1.0 0.692869520175954 56 Q14997,P28072,P60900,P20042,P33527,P40855,O75832,P08183,Q9GZP9,P20618,O75027,P49721,Q92530 13 Biosynthesis of specialized proresolving mediators spms 0.8597256857855382 1.695800227962741 0.089923719313862 1.0 0.7141037272009417 2 Q14914 1 O linked glycosylation of mucins 0.8063785088456041 1.688999521379351 0.0912195216760984 1.0 0.7141037272009417 5 Q8N4A0 1 O linked glycosylation 0.7089199334227154 1.6827046774216416 0.0924322758103197 1.0 0.7141037272009417 6 Q8N4A0 1 Class i peroxisomal membrane protein import 0.6138558855323563 1.6780007914577566 0.0933469445068657 1.0 0.7141037272009417 10 Q9NR77,P51648 2 Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain 0.8528678304239414 1.6649743654775095 0.095917870210048 1.0 0.7141037272009417 2 P53611 1 Phase i functionalization of compounds 0.5216373365545042 1.6604050592404591 0.0968329930493618 1.0 0.7141037272009417 16 O00170,O43169,Q16850,Q15185,P07099 5 Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways 0.5588676477029723 1.6354423152901196 0.1019563579092817 1.0 0.7143659173718138 12 P42575,P09601,O15111 3 Pi3k akt signaling in cancer 0.5795025201582322 1.6013580700424073 0.1092976340530069 1.0 0.7158867090845438 11 P49840,P63000,O15111,P49841 4 Metabolism of steroids 0.3845766825725134 1.5984635434079115 0.1099398526646742 1.0 0.7158867090845438 46 Q15392,Q14534,O75845,Q86X55,P04062,Q16850,P38435,Q15800,Q14739,P15121,P30536,O00767 12 Aryl hydrocarbon receptor signalling 0.9254943144261022 1.5925578028809613 0.111259426177503 1.0 0.7158867090845438 3 O00170 1 E2f mediated regulation of dna replication 0.5505227820984643 1.5860007828808018 0.1127391319665414 1.0 0.7158867090845438 12 P49643,P30154,P06493,Q9UBD5,O43913,Q14181,P49642,Q9Y619 8 Phase ii conjugation of compounds 0.4455299130889242 1.5845458598896138 0.1130695541829223 1.0 0.7158867090845438 26 Q99735,Q8TB61,Q9NUJ1,P21266,P10768,P21964 6 Bmal1 clock npas2 activates circadian gene expression 0.9183349082306914 1.5800948725565025 0.1140851413775982 1.0 0.7158867090845438 4 P43490 1 Activation of atr in response to replication stress 0.4482425228329204 1.5777469849399877 0.1146237475589262 1.0 0.7158867090845438 25 Q9UBD5,O14757,Q13535,P27694,Q7L590,Q14566,Q9Y619,P15927,O00311 9 Uptake and actions of bacterial toxins 0.6604143920421944 1.573874883119022 0.1155163776548786 1.0 0.71825516595189 7 P13639,Q7L0J3 2 P75ntr regulates axonogenesis 0.9189368736790378 1.566838538079799 0.1171524368774763 1.0 0.7226010207715656 3 Q9NQC3 1 Tp53 regulates transcription of dna repair genes 0.433920118296399 1.5516336389601897 0.1207499094308393 1.0 0.7226010207715656 28 O14757,Q13535,P18615,Q14241,Q14004,Q8IXH7,P04637 7 Autophagy 0.3898726149596608 1.551157557340426 0.1208639305650796 1.0 0.7226010207715656 43 Q14457,Q9NS69,Q8N4H5,O95352,P21796,P67870,Q9NT62,P63167 8 Cytochrome p450 arranged by substrate type 0.9134941326333692 1.5454784665845205 0.1222305735184887 1.0 0.7233525321000513 3 Q16850 1 The citric acid tca cycle and respiratory electron transport 0.3243619042947833 1.5383119857174563 0.1239723505444567 1.0 0.7233525321000513 91 Q9Y6M9,P53985,P21796,P03886,O95298,Q8NCN5,Q9P0J0,O43676,Q86Y39,P31040,P35613,P51970,P48735,O75964,Q9H9P8,Q9UDW1,O14949,P00403,O75306,P31930,P14854,O75947,P20674,P13073 24 Platelet homeostasis 0.5301700206766288 1.5367458656799071 0.1243555546324248 1.0 0.7233525321000513 13 P23634,Q16537,P30626,P63218,Q06124,Q16539,P16615,P62873 8 Gpvi mediated activation cascade 0.7686929012372059 1.530372021275849 0.1259246703503735 1.0 0.7233525321000513 5 P60953,P61586,P63000 3 Cytoprotection by hmox1 0.349471827126494 1.50572552943808 0.1321376474903099 1.0 0.7366004186220036 66 P14854,Q14997,Q86X55,P09601,P28072,P60900,O75376,P33527,O75832,P67870,P20674,P20618,P00403,P30519,P49721,Q92530,P13073 17 Diseases of immune system 0.9031282810850316 1.5047711335381873 0.1323829276338766 1.0 0.7366004186220036 3 P09429 1 Ras processing 0.667366675958565 1.492073651049438 0.1356798384851549 1.0 0.7366004186220036 6 O60725,P49354 2 Oncogene induced senescence 0.6668353025958813 1.4896224487084864 0.1363235360101562 1.0 0.7366004186220036 6 P11802,P04637,Q9HCE1 3 Transport of vitamins nucleosides and related molecules 0.6182000606407618 1.487379957072509 0.1369144874516377 1.0 0.7366004186220036 8 O00400,Q99808 2 Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 0.349571210243717 1.4851552503096006 0.1375027030801008 1.0 0.7366004186220036 62 Q9P0J0,O75964,Q9Y6M9,P31930,P14854,O43676,Q9UDW1,O75947,O14949,Q86Y39,P20674,P13073,P00403,P03886,O95298,O75306,P31040,P51970 18 Maturation of sars cov 1 nucleoprotein 0.8126558603491292 1.4837851764828025 0.1378659209111461 1.0 0.7366004186220036 2 P49840 1 Akt phosphorylates targets in the cytosol 0.6654637259773623 1.4832940986120742 0.1379962895919475 1.0 0.7366004186220036 6 P49840,O15111 2 Constitutive signaling by akt1 e17k in cancer 0.6390535058684977 1.471414366729488 0.1411790904486718 1.0 0.7414743480951164 7 P49840,O15111 2 Recycling of eif2 gdp 0.6370279975188269 1.4616706719457726 0.1438314777580425 1.0 0.7414743480951164 7 Q13144,P49770,P20042 3 Sulfur amino acid metabolism 0.5534778666589283 1.4545669269549673 0.1457891926212859 1.0 0.7416693835533785 11 Q13126 1 Tnf signaling 0.5904674438797881 1.4449174519205104 0.1484810736788846 1.0 0.7497803058469595 9 P63244,P78536 2 Nod1 2 signaling pathway 0.6053333998055785 1.4227657111256091 0.1548040844300224 1.0 0.765268247765376 8 P42575,O15111 2 Dscam interactions 0.7976932668329201 1.4162987600436598 0.1566880507336008 1.0 0.7661668302805833 2 Q16539 1 Mapk1 erk2 activation 0.7951995012468851 1.405054486632179 0.1600050766192837 1.0 0.7745574470255294 2 P28482 1 Dna damage recognition in gg ner 0.4888184831904156 1.390302173998873 0.164437137984116 1.0 0.7810833107051108 15 Q9H981,P25490 2 Traf6 mediated nf kb activation 0.6443555192069658 1.3856894165900215 0.1658417612371385 1.0 0.7838264323336379 6 P09429 1 Beta oxidation of very long chain fatty acids 0.6204659596733999 1.3818509923340536 0.1670174582238979 1.0 0.7867253335193036 7 Q15067 1 Response of eif2ak4 gcn2 to amino acid deficiency 0.3290048112974606 1.3691352472857947 0.1709570022550375 1.0 0.7939270606531256 79 P18077,P20042,P61927,P27635,P46778,P62910,P61254,P62753,P25398,P46782,P39023,P46776,P62266,P62273,P62263,P15880,Q9Y3U8,P84098,P08243,P62917,P83881,P61513 22 Rho gtpases activate wasps and waves 0.4695402577094119 1.3677708148041474 0.1713838258164717 1.0 0.7939270606531256 17 P60953,Q92747,P28482,P63000,O15143,Q9UQB8 6 Eukaryotic translation initiation 0.3076574120613252 1.3653866580969884 0.1721315550238884 1.0 0.794538567905414 102 P18077,O75822,P20042,P61927,P27635,P46778,P62910,Q13347,P61254,P62753,P25398,P46782,P39023,P46776,P62266,P49770,P62273,P62263,P15880,Q13144,Q9Y3U8,P84098,P62917,P83881,P11940,P61513 26 Cyclin a b1 b2 associated events during g2 m transition 0.5535073045827889 1.351126536486432 0.1766549022507559 1.0 0.794538567905414 10 P30154,P06493,Q99640,P24941,O95067,Q9Y570,P53350 7 Interconversion of nucleotide di and triphosphates 0.4585197541056632 1.348088555582239 0.1776299018856919 1.0 0.794538567905414 18 Q9H773,Q9NRF8,P35754,P17812,P23921,P00390,P04818,Q16881 8 Synthesis of leukotrienes lt and eoxins ex 0.8599937636420346 1.33524870217509 0.1817949618371912 1.0 0.794538567905414 3 Q14914,P33527 2 Abacavir transport and metabolism 0.7793017456359136 1.333427441192035 0.1823915721145279 1.0 0.794538567905414 2 P08183 1 Condensation of prometaphase chromosomes 0.5501928472299235 1.3330309063011432 0.1825216616141221 1.0 0.794538567905414 10 O95067,P67870,Q15003 3 E2f enabled inhibition of pre replication complex formation 0.6315980053077657 1.3265478554234411 0.1846582947908057 1.0 0.794538567905414 6 Q9Y619,Q9UBD5,P06493 3 Peroxisomal lipid metabolism 0.4827612823383815 1.305893806855049 0.1915886729782934 1.0 0.794538567905414 14 Q08426,Q15067,P51648 3 Methylation 0.6159897781152186 1.2541081875525282 0.2098026848108607 1.0 0.8117603168935206 6 P78417,P21964,P23526 3 Ptk6 regulates rho gtpases ras gtpase and map kinases 0.7008906943106913 1.242753272730528 0.2139587662904261 1.0 0.814838938637744 5 P61586,P46108 2 Raf independent mapk1 3 activation 0.6133037797174321 1.2416386852925094 0.2143699017950084 1.0 0.814838938637744 6 P28482,P06493 2 Polb dependent long patch base excision repair 0.6993415480619067 1.236175179839712 0.2163934544908237 1.0 0.8159958027834565 5 P27695,P18858,P39748 3 Transcriptional regulation by e2f6 0.5263074055111752 1.2024514930598615 0.2291886489179613 1.0 0.8460024270085169 10 O14757,O00311 2 Cyclin d associated events in g1 0.542103003270944 1.1913731558211098 0.2335071263967694 1.0 0.8467873671364665 9 P63208,P30154,Q13309,P11802,Q00534 5 Ion transport by p type atpases 0.5070360963663478 1.1905284704526906 0.2338387468006886 1.0 0.8467873671364665 11 P23634,Q9HD20 2 Synthesis of pips at the golgi membrane 0.558452742590365 1.1862821222815485 0.2355109043572669 1.0 0.8467873671364665 8 Q9UBF8,Q9NTJ5,Q10713,Q9BTU6,Q01968 5 Cd163 mediating an anti inflammatory response 0.8201340576250221 1.1790829839186865 0.2383651336160102 1.0 0.8477118472394338 3 P78536 1 Basigin interactions 0.5990705108738952 1.1755781058566577 0.2397635087852041 1.0 0.8477118472394338 6 P53985 1 Acyl chain remodelling of pc 0.7422069825436441 1.1670856279793245 0.2431757912440302 1.0 0.8497229714842567 2 Q8NF37 1 G protein beta gamma signalling 0.682172167241552 1.163335609188028 0.2446933634349775 1.0 0.8515572523520735 5 P60953,P61586,P63218 3 Nonsense mediated decay nmd 0.3044315168134788 1.152121654686589 0.2492710858190192 1.0 0.8586227271761058 87 P18077,P61927,P27635,P46778,P62910,P61254,P62753,P25398,Q09161,P46782,P39023,P46776,P62266,P62273,P62263,P15880,Q9Y3U8,P84098,P62917,P83881,P11940,P61513 22 Tp53 regulates transcription of cell death genes 0.593150963793417 1.148124460996507 0.2509171875010398 1.0 0.8586227271761058 6 P42575,P53611 2 Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux 0.6783166681169128 1.1470025840522324 0.2513805529501094 1.0 0.8586227271761058 5 Q9HCE1 1 Mitotic g1 phase and g1 s transition 0.3108978550398352 1.1315772620436644 0.2578122040273078 1.0 0.8586227271761058 80 P06493,P11802,O75832,Q7L590,Q9UBD5,P60900,P27694,P49642,Q14566,P49721,Q9Y619,P15927,P04818,P62191,O00311,P28066,O43913,P28072,Q13309,P20618,Q92530,P00374,Q14181,P56282 24 Hedgehog ligand biogenesis 0.3514140597120966 1.1257819781243914 0.2602578142159579 1.0 0.8586227271761058 42 Q14997,P07237,P28072,P60900,O75832,Q9GZP9,P78536,P20618,P49721,Q92530 10 Gpcr ligand binding 0.5083322782625519 1.104200711862661 0.2695060809392342 1.0 0.869140448349332 10 P04083,P63218,Q9NZJ7,Q9NRV9,Q9Y3E5,P07602,P62873 7 Deubiquitination 0.288850007886944 1.0972493172318256 0.2725324198246459 1.0 0.8696526710393461 100 P06493,Q9UPU5,O75832,P21796,Q9H981,P25490,Q14457,O94966,P60900,P51784,Q96RL1,P45880,P49721,P62191,Q9Y4E8,P61586,P28072,Q9NWV8,O94826,P20618,P04637,Q92530,Q14997,Q9Y277 24 Hiv transcription elongation 0.4145194869166592 1.0901178569030965 0.2756612312521951 1.0 0.8696526710393461 19 Q14241,P18615,Q09161,Q8IXH7 4 Sialic acid metabolism 0.787736365196564 1.0846102045541115 0.2780943334592898 1.0 0.8723183240124359 4 Q8NFW8,Q9NR45 2 Gamma carboxylation hypusine formation and arylsulfatase activation 0.4658648434447409 1.0790345676768816 0.2805723180861501 1.0 0.8729489295658882 12 O60725,O43681 2 Synthesis of pc 0.576716394865534 1.0720368363122244 0.283703487188254 1.0 0.8729489295658882 6 Q9NQZ5,Q8NF37 2 Dna replication initiation 0.5353253671211696 1.0696491452867871 0.2847772650344335 1.0 0.8729489295658882 8 P56282,P49642,Q14181 3 Mrna decay by 3 to 5 exoribonuclease 0.4457066185042647 1.0694114549599911 0.2848843079457901 1.0 0.8729489295658882 14 Q6PGP7 1 Regulation of tnfr1 signaling 0.5760037928144875 1.068743674593654 0.2851851858524723 1.0 0.8729489295658882 6 P63244 1 Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.4852347849790831 1.0665215894400617 0.2861879245670014 1.0 0.8729489295658882 11 O43681,P09601,P51648,P46379 4 Rho gtpases activate nadph oxidases 0.5711312033436036 1.046242838255761 0.2954489292610001 1.0 0.8863638705076758 6 P28482,P63000,Q16539 3 Transport of bile salts and organic acids metal ions and amine compounds 0.7765196387882795 1.0424820952462222 0.2971882223615392 1.0 0.8863638705076758 4 P53985 1 Pcna dependent long patch base excision repair 0.4074896770372094 1.0388313317579465 0.2988831868948978 1.0 0.8863638705076758 19 P18858,P39748,P27694,P56282,P27695,P15927 6 Sema4d induced cell migration and growth cone collapse 0.5680695665953052 1.0321211682687883 0.3020153584962919 1.0 0.8863638705076758 6 P61586 1 Potassium channels 0.7113466334164626 1.0303488635689282 0.3028462688367899 1.0 0.8863638705076758 2 P63218 1 Prostacyclin signalling through prostacyclin receptor 0.7113466334164626 1.0303488635689282 0.3028462688367899 1.0 0.8863638705076758 2 P63218 1 G protein activation 0.7113466334164626 1.0303488635689282 0.3028462688367899 1.0 0.8863638705076758 2 P63218 1 Presynaptic function of kainate receptors 0.7113466334164626 1.0303488635689282 0.3028462688367899 1.0 0.8863638705076758 2 P63218 1 Glucagon type ligand receptors 0.7113466334164626 1.0303488635689282 0.3028462688367899 1.0 0.8863638705076758 2 P63218 1 Inwardly rectifying k channels 0.7113466334164626 1.0303488635689282 0.3028462688367899 1.0 0.8863638705076758 2 P63218 1 Dap12 interactions 0.6487011512996774 1.0220426437459935 0.3067607177159959 1.0 0.8909679454688305 5 P10321,P63000 2 Neddylation 0.3103805470196399 1.005661789465029 0.3145782898033209 1.0 0.8963282150069063 66 Q9NV06,Q8NEZ5,Q14997,P28072,P61962,P60900,Q9Y5A7,O75832,Q15345,P20618,Q9BT78,P49721,Q92530,P62191,Q13098 15 Fructose metabolism 0.7753719683354734 1.0056491496730728 0.3145843721288734 1.0 0.8963282150069063 3 P15121 1 Processive synthesis on the lagging strand 0.4355896202090459 1.0051665261872076 0.3148166705874955 1.0 0.8963282150069063 14 P18858,Q14181,P51530,P27694,P39748,P15927 6 Metabolism of steroid hormones 0.5620347373083191 1.004328083263216 0.3152205016321643 1.0 0.8963282150069063 6 P15121,P30536 2 Fgfr2 alternative splicing 0.4437648455240998 1.0026765722409634 0.3160169370997958 1.0 0.8967701724190961 13 Q09161,P31943,P52597 3 Pregnenolone biosynthesis 0.7636503548628035 0.994372617026442 0.3200414942861336 1.0 0.9026976824723808 4 P15121,P30536 2 Cd28 dependent vav1 pathway 0.7608365856813312 0.9838905197592271 0.325169345467299 1.0 0.9080078129915196 4 P60953 1 Metalloprotease dubs 0.5369195600628818 0.9786144987143204 0.3277704926828946 1.0 0.9096035282474884 7 Q9NWV8 1 Complex i biogenesis 0.3654182217330002 0.9690905279651346 0.3325000232454607 1.0 0.9120932010203912 28 Q9P0J0,Q9Y6M9,O43676,P51970,Q86Y39,P03886,O95298,O75306,O95299 9 Synthesis of very long chain fatty acyl coas 0.51234821386111 0.9544256977528324 0.3398682035198144 1.0 0.921464373496551 8 Q4G176,O60488,Q9P035,P33121 4 Epha mediated growth cone collapse 0.495781520100764 0.9491427898059028 0.3425479939886697 1.0 0.9262910460260484 9 P61586 1 Activation of nima kinases nek9 nek6 nek7 0.630889235569427 0.9475243797695974 0.3433716391679984 1.0 0.9262910460260484 5 O95067,P14635,P06493,P53350 4 Cooperation of pdcl phlp1 and tric cct in g protein beta folding 0.4339837227715549 0.9426719347488836 0.3458487328859556 1.0 0.927537866281896 13 P67870,Q13371,P63218,P49368 4 Glycogen breakdown glycogenolysis 0.5292158152678073 0.9417937747142476 0.3462982330039006 1.0 0.927537866281896 7 P35573,P46976,P46020 3 Slc transporter disorders 0.3529903224848917 0.9404171105087192 0.3470036488776973 1.0 0.927537866281896 32 P53985,O00400,Q9BTX1 3 Endosomal vacuolar pathway 0.7489082969432398 0.9396203687286466 0.3474123244687015 1.0 0.927537866281896 4 P10321,Q9UIQ6,P04439 3 The phototransduction cascade 0.5469143936505378 0.9349935684254184 0.3497916139654233 1.0 0.9317171576948408 6 P53582,P49354 2 Platelet sensitization by ldl 0.5438682450594774 0.9210876682839928 0.3570046579789934 1.0 0.933123396043972 6 Q06124,Q16539,Q16537 3 Parasite infection 0.3650712465423389 0.9205884324954764 0.3572653437643325 1.0 0.933123396043972 26 P60953,Q92747,P28482,P63000,P46108,O15143,Q9UQB8 7 Suppression of apoptosis 0.5434472962246408 0.919167862935961 0.3580077777061916 1.0 0.933123396043972 6 P28482,P49840,Q63HN8 3 Cytosolic trna aminoacylation 0.3713133026305551 0.9166298881867492 0.3593366170034451 1.0 0.933123396043972 23 P49591,Q9Y285,P26639,P49589,P26640,Q9P2J5,P54136,P07814,O43776 9 Caspase activation via dependence receptors in the absence of ligand 0.6851620947630965 0.9163092872342954 0.3595046982722105 1.0 0.933123396043972 2 P42574 1 Regulation of tp53 expression and degradation 0.4736824215272505 0.9159988446622748 0.3596675008750611 1.0 0.933123396043972 10 O96017,P30154,P06493,P24941,P04637 5 Eukaryotic translation elongation 0.2959314129125048 0.9147733510353886 0.3603106275980552 1.0 0.933123396043972 79 P18077,P61927,P27635,P46778,P62910,P61254,P62753,P25398,P46782,P39023,P46776,P62266,P62273,P62263,P15880,Q9Y3U8,P84098,P62917,P83881,P61513 20 Resolution of ap sites via the multiple nucleotide patch replacement pathway 0.3808164082521162 0.9116786750511856 0.3619378929638646 1.0 0.933123396043972 21 P18858,P39748,P27694,P56282,P27695,P15927 6 Activation of bh3 only proteins 0.4575290782483162 0.91006259302318 0.3627895006602544 1.0 0.933123396043972 11 Q04917,P63167 2 Cellular response to chemical stress 0.2978591331030958 0.9100167334392144 0.3628136850351355 1.0 0.933123396043972 76 P14854,Q14997,Q86X55,P09601,P07237,P28072,P60900,O75376,P33527,O75832,P67870,P20674,P20618,P00403,P30519,P49721,Q92530,P13073 18 Creatine metabolism 0.7496102276270737 0.9075191406048868 0.3641323323136851 1.0 0.933123396043972 3 P12532,P12277 2 Regulation of expression of slits and robos 0.3004534384661642 0.9064606620759552 0.3646920771914193 1.0 0.933123396043972 126 P18077,O75832,P61927,P27635,P46778,P62910,P61254,P62753,P60900,P25398,P35268,Q09161,P46782,P49721,P39023,P46776,P62266,P28072,P62273,P62263,P20618,Q92530,O43347,P15880,Q9Y3U8,Q14997,P84098,P62917,P83881,P11940,P61513 31 Ub specific processing proteases 0.2967721525250814 0.9051384618212392 0.3653920382469993 1.0 0.933123396043972 77 Q14457,O94966,Q14997,P28072,P60900,Q9Y277,O75832,P21796,P51784,P45880,P20618,P04637,P49721,Q92530,P62191,Q9Y4E8 16 Tak1 activates nfkb by phosphorylation and activation of ikks complex 0.5213660492608745 0.9044253670254532 0.3657698922373829 1.0 0.933123396043972 7 P09429 1 Abortive elongation of hiv 1 transcript in the absence of tat 0.434813742970217 0.8941778902935041 0.3712267198831713 1.0 0.936282336413966 12 P18615,Q09161,Q8IXH7 3 Transcription of the hiv genome 0.3732709712226228 0.8917754663475563 0.3725132942154689 1.0 0.936282336413966 22 Q14241,P18615,Q09161,Q8IXH7 4 Signaling by braf and raf1 fusions 0.3654419713153299 0.8864499242383646 0.3753751268997281 1.0 0.936282336413966 24 P30086,O95352,Q9NRY5,Q96PU8 4 Nucleotide biosynthesis 0.4157512504965599 0.8801996085689717 0.3787511855111205 1.0 0.936282336413966 14 Q06203,P30520 2 Formation of fibrin clot clotting cascade 0.7421655343760494 0.8794791942821626 0.3791415092135928 1.0 0.936282336413966 3 P42785 1 Cobalamin cbl vitamin b12 transport and metabolism 0.6086043350437562 0.8553204889810583 0.3923737477580036 1.0 0.954662388023386 5 Q96EY8 1 Mitochondrial calcium ion transport 0.3946349884286599 0.8531240604560626 0.3935905099492593 1.0 0.9559602837135658 17 P21796,P45880 2 Hsf1 activation 0.4099235385618406 0.8438463699713626 0.3987552599988908 1.0 0.9651533023156544 14 Q15185,P15927,P27694 3 Formation of the early elongation complex 0.4042914053570223 0.8409145247796709 0.4003958207706009 1.0 0.9674503510502084 15 P18615,Q09161,Q8IXH7 3 Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand 0.3449948570237581 0.8359274877049336 0.4031956975489736 1.0 0.9691937815653164 30 Q9UJW0,P31689,P31948,O60884,Q15185,P63167 6 Rho gtpases activate ktn1 0.5055533381120619 0.8297207897574744 0.406696664337159 1.0 0.975932475827934 7 P60953,P61586,Q07866 3 Response of eif2ak1 hri to heme deficiency 0.7180880279999969 0.8267529673204624 0.4083770929143193 1.0 0.9776577895790356 4 P08243,P20042 2 Synthesis of pa 0.4424545264711405 0.8259837672300323 0.4088133001456295 1.0 0.9776577895790356 11 Q8N2A8 1 Tp53 regulates transcription of genes involved in g1 cell cycle arrest 0.6636533665835458 0.824565176272439 0.4096184987965641 1.0 0.9779117403010122 2 P04637 1 Regulation of tp53 activity through phosphorylation 0.3392243029502358 0.8193855885780229 0.4125664545864 1.0 0.9785934052663908 32 Q9Y5B9,O96017,Q13526,O14757,Q13535,P51530,P27694,Q16539,P67870,P40938,P04637,P15927 12 Heme biosynthesis 0.521199798963468 0.8184598215225755 0.4130946752290256 1.0 0.9785934052663908 6 P22830 1 Transport of small molecules 0.3174049335395856 0.8172732187669294 0.4137723079838711 1.0 0.9785934052663908 153 P20042,P33527,P53985,P21796,P16615,P30519,Q99808,Q9HD20,Q8TB61,Q8N4V1,P09601,O00400,Q10713,Q9UBX3,P45880,Q8WTV0,Q70HW3,P49721,P35613,Q93050,P07237,P28072,P35610,P20618,P12235,O75027,Q92530,P23634,Q14997,P40855,Q9Y277,P08183,Q9GZP9,O15118 34 G2 m dna replication checkpoint 0.7149218589855295 0.8153062997579997 0.4148970036405575 1.0 0.9785934052663908 4 Q99640,O95067 2 G2 m checkpoints 0.2723336722430331 0.7973946569585866 0.4252218613897338 1.0 0.9896286998486586 93 P06493,O14757,O75832,Q7L590,O95067,Q9UBD5,Q99640,P60900,P27694,Q96RL1,Q14566,P49721,Q9Y619,P15927,P62191,O00311,O96017,P28066,P28072,Q9NWV8,P20618,P04637,Q92530,Q04917,Q14997,Q13535,P51530 27 Orc1 removal from chromatin 0.2961170454309284 0.796945938297577 0.4254824295565398 1.0 0.9896286998486586 51 P20618,Q9UBD5,Q14997,P28072,P60900,P49721,O75832,Q14566,Q9Y619,Q92530 10 Regulation of tp53 activity through methylation 0.709632527952761 0.79625467275416 0.4258840255754423 1.0 0.9896286998486586 4 O96017,P04637 2 Pyruvate metabolism and citric acid tca cycle 0.3385345253222162 0.7962250659605333 0.4259012308075862 1.0 0.9896286998486586 31 Q8NCN5,P53985,P21796,P35613 4 Aflatoxin activation and detoxification 0.7194760866589558 0.7951059076000616 0.4265518985051759 1.0 0.9896286998486586 3 Q99735 1 Ire1alpha activates chaperones 0.3491907297987467 0.7924430382612694 0.4281023928641172 1.0 0.9902645465001948 26 P49840,Q9Y5M8,Q06210,O94979,Q9HCU5,P43307,Q9NWM8 7 Cellular response to starvation 0.2732853450857024 0.7920312846574801 0.428342434863658 1.0 0.9902645465001948 92 P18077,P20042,P61927,P27635,P46778,P62910,P61254,P62753,P25398,P46782,P39023,P46776,P62266,P62273,P62263,P15880,Q9Y3U8,P84098,P08243,P62917,P83881,P61513 22 Cd28 co stimulation 0.4790197381265375 0.7897782006542096 0.4296573121698486 1.0 0.9902645465001948 8 P60953 1 Signaling by fgfr2 0.3680874220143116 0.7848657757539733 0.4325322699764635 1.0 0.9910246758077116 20 P52597,P28482,Q01085,P31943,Q09161,Q06124 6 Signaling by fgfr 0.3680874220143116 0.7848657757539733 0.4325322699764635 1.0 0.9910246758077116 20 P52597,P28482,Q01085,P31943,Q09161,Q06124 6 Cdt1 association with the cdc6 orc origin complex 0.3192928482437391 0.7846567620277234 0.4326548401177099 1.0 0.9910246758077116 41 Q9UBD5,Q14997,Q9Y619,P28072,P60900,O75832,P20618,P49721,Q92530 9 Signaling by type 1 insulin like growth factor 1 receptor igf1r 0.5906424242537208 0.7821163603000486 0.4341461927579657 1.0 0.9910246758077116 5 O14654 1 Maturation of sars cov 2 nucleoprotein 0.5130388782007113 0.7819611553150346 0.4342374026233933 1.0 0.9910246758077116 6 P49840,P49841,Q99873,P78362 4 Death receptor signalling 0.33953351346933 0.7766240940816186 0.4373805820833563 1.0 0.994951925747342 29 P42575,P61586,P63244,Q9NQC3,P78536 5 Pexophagy 0.6511845386533716 0.7723889250847394 0.4398841112767029 1.0 0.9990225189547196 2 Q13501 1 G beta gamma signalling through cdc42 0.7115684440286911 0.7661388356307383 0.443593697351905 1.0 0.999335881796026 3 P60953,P63218 2 Class b 2 secretin family receptors 0.7115684440286891 0.7661388356307308 0.4435936973519094 1.0 0.999335881796026 3 P63218,Q9Y3E5 2 Adp signalling through p2y purinoceptor 1 0.7115684440286856 0.7661388356307177 0.4435936973519172 1.0 0.999335881796026 3 Q16539,P63218 2 Purine ribonucleoside monophosphate biosynthesis 0.4445644308224102 0.7607476774447098 0.4468077915573338 1.0 1.0 10 P30520 1 Signal transduction by l1 0.4905095919508647 0.7595455909311617 0.4475262524366878 1.0 1.0 7 P28482,P67870 2 Ephb mediated forward signaling 0.3910291762336895 0.7571682844390278 0.4489490485731422 1.0 1.0 15 P60953,P61586,P63000,Q92747 4 Rho gtpases activate cit 0.4297944285847356 0.7562421928483997 0.4495039998734522 1.0 1.0 11 P60660,Q15334,P61586 3 Interferon alpha beta signaling 0.4414831124126699 0.7445662167803964 0.4565339972571292 1.0 1.0 10 P10321,Q06124,Q9Y3Z3,P04439 4 Interleukin 12 signaling 0.3406298442898009 0.7428429498556794 0.4575767688928183 1.0 1.0 27 P52597,Q99439,Q13126,O00170,P07237,O14979,P22626,Q9H3K6 8 Hiv elongation arrest and recovery 0.3885043248451408 0.7413866627961488 0.4584590288780137 1.0 1.0 15 Q14241,P18615,Q8IXH7 3 Transcriptional regulation of white adipocyte differentiation 0.3875096480869927 0.7351853179249279 0.4622266394494629 1.0 1.0 15 P11802,Q86X55 2 Displacement of dna glycosylase by apex1 0.6923964168323551 0.7348450234220847 0.4624338833622226 1.0 1.0 4 P27695 1 Resolution of abasic sites ap sites 0.3388441851204647 0.7285570931871473 0.4662726327093254 1.0 1.0 27 P29372,P18858,P39748,P27694,P56282,P27695,P15927 7 Glutathione conjugation 0.3911419501843983 0.7282533880271278 0.4664584899602111 1.0 1.0 14 P21266,Q99735,P10768 3 Signaling by erbb4 0.4509577540578001 0.7202168428596143 0.4713914952859965 1.0 1.0 9 O75376,P78536 2 Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex 0.4228325177334113 0.7183147664696607 0.4725632273515332 1.0 1.0 11 P06493,Q04917,O14757 3 Reduction of cytosolic ca levels 0.6870906281028575 0.7161686225141177 0.4738872352893633 1.0 1.0 4 P16615,P23634 2 Synthesis of ip3 and ip4 in the cytosol 0.6352867830423992 0.707147481015085 0.4794748319574085 1.0 1.0 2 Q01968 1 Downregulation of tgf beta receptor signaling 0.47903870715843 0.7067744826625857 0.4797066344611798 1.0 1.0 7 P62136,Q9Y3F4,Q9Y4E8 3 Diseases of mismatch repair mmr 0.6949822192436154 0.7062389478904274 0.4800395532536508 1.0 1.0 3 P20585 1 G1 s specific transcription 0.4197443383532647 0.7016011322668745 0.4829279453186836 1.0 1.0 11 Q9Y619 1 Mapk6 mapk4 signaling 0.2960970297526035 0.7010336570766869 0.4832820110675579 1.0 1.0 48 P60953,P06493,P28066,Q14997,P63000,Q9HCE1,P28072,P60900,O75832,Q16181,P20618,P49721,Q92530,P62191 14 Association of tric cct with target proteins during biosynthesis 0.3711441129194515 0.69715146820496 0.4857080072998947 1.0 1.0 17 P51784,P04062,P61962 3 Regulation of runx1 expression and activity 0.6919239164328056 0.695332309618595 0.4868470706151444 1.0 1.0 3 Q06124,Q9HCE1 2 Pyrimidine catabolism 0.6306109725685838 0.6882645059263125 0.4912862290798174 1.0 1.0 2 Q9H0P0 1 Gene and protein expression by jak stat signaling after interleukin 12 stimulation 0.3364114530283949 0.6757024084808213 0.4992296065069546 1.0 1.0 25 P52597,Q99439,Q13126,O00170,O14979,P22626,Q9H3K6 7 Signaling by erbb2 0.4145763230064649 0.6737964763424451 0.5004407153755515 1.0 1.0 11 P61586,Q9UNE7,Q16543 3 Peptide ligand binding receptors 0.4713204101552447 0.6716915908000298 0.5017800559315648 1.0 1.0 7 P04083,P07602 2 Class a 1 rhodopsin like receptors 0.4713204101552447 0.6716915908000298 0.5017800559315648 1.0 1.0 7 P04083,P07602 2 G beta gamma signalling through pi3kgamma 0.6736107416957023 0.6692584273524657 0.5033306410937066 1.0 1.0 4 P61586,P63218 2 Signaling by ptk6 0.3796390466125668 0.6589696634660606 0.5099152494892283 1.0 1.0 14 P61586,P63000,P11802,P46108,P04150 5 Signaling by robo receptors 0.2946900492295966 0.6584682346308717 0.5102373021284183 1.0 1.0 139 O75122,P18077,O75832,P61927,P27635,P46778,P62910,P61254,P62753,P60900,P25398,P35268,Q09161,P46782,P49721,P39023,P62191,P61586,P46776,P62266,P28072,P62273,P62263,P20618,Q92530,O43347,P15880,Q9Y3U8,Q14997,P84098,P62917,P83881,P11940,P61513 34 Cdc6 association with the orc origin complex 0.6704269025859982 0.658299307179332 0.5103458230948932 1.0 1.0 4 Q9UBD5,Q9Y619 2 Smooth muscle contraction 0.4115637739539636 0.6576901244306614 0.5107372694250014 1.0 1.0 11 P09493,P60660,P06753 3 Perk regulates gene expression 0.3793068019513861 0.6569890529294387 0.511187955417161 1.0 1.0 14 P41091,P20042,Q9NQT5,Q9NPD3,P08243,Q9Y2L1,Q92945 7 Costimulation by the cd28 family 0.3771673089938759 0.6442648407395216 0.5194037107689091 1.0 1.0 14 P60953,P63000,Q16537,Q06124 4 Lagging strand synthesis 0.3515000342982727 0.6411922289296368 0.5213977979335787 1.0 1.0 19 P18858,Q14181,P51530,P27694,P39748,P40938,P15927 7 Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1 0.6742764123036961 0.6333352681057521 0.5265147268865336 1.0 1.0 3 P06493 1 Selenoamino acid metabolism 0.2607904945427089 0.6324329643103337 0.5271039993953135 1.0 1.0 93 P18077,P49207,P61927,P00390,P27635,P46778,P62910,P61254,P61313,P62753,P25398,P35268,P54136,P07814,P46782,P39023,P49591,P46776,P62266,P62273,P62263,P83881,P15880,Q9Y3U8,P84098,P62917,P42677,P61513,Q16881 29 Inhibition of replication initiation of damaged dna by rb1 e2f1 0.4773483432798471 0.6262498686030478 0.5311510624470936 1.0 1.0 6 P49642,P30154,Q14181 3 Interleukin 1 signaling 0.2861193591998838 0.624441264361669 0.5323378325716841 1.0 1.0 49 O15111,Q14997,P28072,P09429,P60900,O75832,P20618,Q13501,P49721,Q92530 10 G1 s dna damage checkpoints 0.3019503849727497 0.619691502165498 0.5354609114379014 1.0 1.0 41 O96017,O14757,Q14997,P28072,P60900,O75832,P20618,P04637,P49721,Q92530,P62191 11 Fcgamma receptor fcgr dependent phagocytosis 0.3116095298611394 0.6179799954664318 0.5365885253558518 1.0 1.0 34 P60953,Q92747,P28482,P63000,Q8IV08,P46108,O15143,Q9UQB8 8 Protein folding 0.3136548099432124 0.6177429879363642 0.53674477017764 1.0 1.0 33 P61962,P51784,P67870,P61758,Q99471 5 Regulation of hmox1 expression and activity 0.2959012869491641 0.6090400336463657 0.5424979035901663 1.0 1.0 44 Q14997,P09601,P28072,P60900,O75832,P67870,P20618,P49721,Q92530 9 Depolymerisation of the nuclear lamina 0.4275407704761054 0.6051376055600342 0.5450875692406065 1.0 1.0 9 P42166,P06493,P50402 3 Repression of wnt target genes 0.6546396208703996 0.6047064258477047 0.545374077764941 1.0 1.0 4 Q13363 1 Ra biosynthesis pathway 0.6656519988493902 0.6036687961113084 0.5460638638829611 1.0 1.0 3 Q8TC12 1 Platelet calcium homeostasis 0.5444163469082623 0.6003687143372007 0.5482605333077046 1.0 1.0 5 P16615,P23634 2 Fceri mediated mapk activation 0.4551109878479866 0.5993200734372015 0.5489594644254274 1.0 1.0 7 P28482 1 Alpha oxidation of phytanate 0.6623179413765709 0.5923205534721026 0.5536359551243428 1.0 1.0 3 P51648 1 Disorders of transmembrane transporters 0.2719852635355667 0.5883103427846961 0.556324004595856 1.0 1.0 77 P20618,Q14997,O00400,P28072,P60900,P53985,O75832,P78406,Q9GZP9,Q9BTX1,P49721,Q92530,P35613 13 Rac3 gtpase cycle 0.3096665847694232 0.584484699249487 0.558894256518637 1.0 1.0 33 O15498,P50402,P42166,O15173,Q9UQB8 5 Interferon gamma signaling 0.3802967971228523 0.5822431301979852 0.5604029256176875 1.0 1.0 12 P10321,Q06124,P29372,P04439 4 Sema4d in semaphorin signaling 0.4341743215638823 0.577158912366489 0.5638321101735555 1.0 1.0 8 P61586 1 Ovarian tumor domain proteases 0.4210792197056709 0.5741733786276817 0.5658504820432906 1.0 1.0 9 P61586,P04637 2 Tp53 regulates transcription of caspase activators and caspases 0.6512900453159929 0.5552917881170132 0.5786950948306337 1.0 1.0 3 P42575 1 Unfolded protein response upr 0.2931826512777558 0.5522091634191914 0.5808050569339802 1.0 1.0 42 P49840,Q9Y5M8,P20042,Q06210,O94979,Q9HCU5,P08243,P43307,Q92945,Q9NWM8 10 Activation of the ap 1 family of transcription factors 0.6493127478268368 0.5487383396153055 0.5831850310100095 1.0 1.0 3 Q16539 1 Abc transporters in lipid homeostasis 0.6367706514000455 0.545711749095962 0.5852640944024592 1.0 1.0 4 P40855 1 Downregulation of erbb2 signaling 0.4568186185429252 0.5405031991156626 0.5888500553630069 1.0 1.0 6 Q9UNE7,Q16543 2 Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol 0.6457840578658676 0.5371105220803233 0.5911912730806672 1.0 1.0 3 P22307 1 Signaling by ntrk2 trkb 0.6334559567520636 0.5349822332140081 0.592662142931544 1.0 1.0 4 P63000 1 Phosphorylation of emi1 0.6429685063922657 0.5278959414673288 0.5975715617704584 1.0 1.0 3 P06493,P53350 2 Global genome nucleotide excision repair gg ner 0.2911032358848123 0.5209710222842115 0.6023869580457706 1.0 1.0 41 P27694,P56282,Q9H981,P25490,P23025,Q9BT78,P15927,P18858,Q13098 9 Tp53 regulates transcription of genes involved in g2 cell cycle arrest 0.4096700416079531 0.5205021279210389 0.602713645153262 1.0 1.0 9 Q99873,Q86X55,P04637 3 Pentose phosphate pathway 0.421431629724418 0.5196363712776227 0.6033170428256551 1.0 1.0 8 P60891,Q96G03,P29401,P37837 4 Transcriptional regulation by runx2 0.2669957412810247 0.5085591239191537 0.6110612868119316 1.0 1.0 53 P06493,Q14997,P28482,P28072,P60900,P11802,O75832,P49841,P20618,P04150,P49721,Q92530,P62191 13 Atf4 activates genes in response to endoplasmic reticulum stress 0.3820944597602963 0.5049429489669155 0.6135989071322341 1.0 1.0 11 P08243 1 Oncogenic mapk signaling 0.3046001479898275 0.4977908861245772 0.6186314403707478 1.0 1.0 29 P30086,O95352,Q9NRY5,Q96PU8 4 Defective cftr causes cystic fibrosis 0.2852394093175176 0.4938283844453803 0.6214273852770589 1.0 1.0 43 Q14997,P28072,P60900,O75832,Q9GZP9,P20618,P49721,Q92530 8 Cytosolic iron sulfur cluster assembly 0.4448907165885968 0.4923406966696456 0.6224785149677969 1.0 1.0 6 O75027 1 Cytochrome c mediated apoptotic response 0.5151446089652388 0.4922304690012784 0.6225564272836603 1.0 1.0 5 P28482 1 Rho gtpases activate rocks 0.4021573840461205 0.485937675319589 0.6270113552690004 1.0 1.0 9 P61586 1 Leishmania infection 0.2820642018509152 0.4797325210652626 0.6314176001642307 1.0 1.0 44 P60953,Q92747,P28482,P09601,P63000,P63218,P46108,O15143,Q16539,P78536,Q9UQB8 11 Nuclear envelope ne reassembly 0.2829143802031664 0.4730041486791368 0.6362102193446066 1.0 1.0 43 P50402,Q8IXJ6,P42166,Q9BTX1,Q86XL3 5 Ddx58 ifih1 mediated induction of interferon alpha beta 0.3396724500781529 0.4727373409986249 0.6364005824587866 1.0 1.0 16 P09429,O15111,O94826,Q15366 4 Synthesis of pips at the er membrane 0.6243464278560854 0.4684495150582115 0.639463165816617 1.0 1.0 3 Q9NTJ5 1 Methionine salvage pathway 0.6110269477296864 0.4643387942802519 0.6424050337396405 1.0 1.0 4 Q13126 1 Egr2 and sox10 mediated initiation of schwann cell myelination 0.3972729989436621 0.4638287333066139 0.6427704554449438 1.0 1.0 9 Q9NR77,Q16850 2 Bbsome mediated cargo targeting to cilium 0.4205432407118241 0.4525357755003187 0.6508830544700603 1.0 1.0 7 P50990,P78371,P48643,P49368,Q9H0F7,P17987 6 Dap12 signaling 0.6184459710609445 0.4501908626439316 0.6525728242280415 1.0 1.0 3 P63000 1 Downstream signaling of activated fgfr3 0.6180551503656958 0.4489918221434518 0.6534375559795622 1.0 1.0 3 Q06124 1 Downstream signaling of activated fgfr2 0.6180551503656958 0.4489918221434518 0.6534375559795622 1.0 1.0 3 Q06124 1 Downstream signaling of activated fgfr1 0.6180551503656958 0.4489918221434518 0.6534375559795622 1.0 1.0 3 Q06124 1 Downstream signaling of activated fgfr4 0.6180551503656958 0.4489918221434518 0.6534375559795622 1.0 1.0 3 Q06124 1 Regulation of tp53 activity 0.2655024041066886 0.4428612856401061 0.6578660714254374 1.0 1.0 50 Q9Y5B9,O96017,Q8WXI9,P06493,Q13526,O14757,O14744,Q13535,P51530,P27694,Q9NPI1,Q16539,P67870,P40938,P04637,P15927 16 Translation of sars cov 1 structural proteins 0.4032140643771822 0.440416705151672 0.659635328054218 1.0 1.0 8 Q10472,P49840,P49841 3 Ca2 pathway 0.4305893122136399 0.4364767355049419 0.6624908749472995 1.0 1.0 6 Q9HCE1,P63218,O43318 3 Downregulation of erbb4 signaling 0.562967581047388 0.4354739861591323 0.6632184172955826 1.0 1.0 2 Q96J02 1 Signaling by alk in cancer 0.2910335164786336 0.4353276637416723 0.6633246077512143 1.0 1.0 33 Q9HC35,Q63HN8,P28482,Q07866,P62753,O94979,Q13501,P06753,Q86WB0 9 Abc transporter disorders 0.2751973998194227 0.4334348875699104 0.6646988597815977 1.0 1.0 45 Q14997,P28072,P60900,O75832,Q9GZP9,P20618,P49721,Q92530 8 Glycosphingolipid metabolism 0.3265700602826621 0.4214642538403773 0.6734161083866386 1.0 1.0 17 O43681,Q13510,P04062,Q16739 4 Negative regulation of mapk pathway 0.3433769000024785 0.4211640978892482 0.6736352587321717 1.0 1.0 13 P28482,P30086,Q16537 3 Nade modulates death signalling 0.6075648291711038 0.4173036557678823 0.6764563148647222 1.0 1.0 3 P42575 1 Uptake and function of diphtheria toxin 0.5943037099503277 0.4141126223311405 0.6787916291827931 1.0 1.0 4 P13639 1 Sema4d mediated inhibition of cell attachment and migration 0.604136002299998 0.4071595076167579 0.6838908395777139 1.0 1.0 3 P61586 1 Formation of xylulose 5 phosphate 0.6040620771100434 0.4069419890662268 0.6840505955737679 1.0 1.0 3 P14550 1 Stabilization of p53 0.2789212455740821 0.3994502713275568 0.689561458589609 1.0 1.0 39 O96017,Q14997,P28072,P60900,O75832,P20618,P04637,P49721,Q92530,P62191 10 Transcriptional regulation by tp53 0.2587801377880711 0.3959975914968074 0.692106805009221 1.0 1.0 120 O14757,P53611,Q8IXH7,P42575,Q9HCE1,P67870,P15927,Q9NZN8,Q99873,Q8WXI9,Q16539,Q14004,P00403,P04637,Q04917,P14854,Q13535,P18615,Q14241,Q9NQ88,Q8WX92,P13073,Q86X55 23 Insulin receptor signalling cascade 0.4180399146353211 0.3893646457995225 0.6970064211829197 1.0 1.0 6 P28482 1 Tgf beta receptor signaling activates smads 0.3687214275125957 0.3874144481018987 0.698449409298048 1.0 1.0 10 P62136,Q9Y3F4,Q9Y4E8 3 Activation of gene expression by srebf srebp 0.3058315442553013 0.3859995204114667 0.6994970239902649 1.0 1.0 21 Q14534,O75845,Q16850,Q86X55,O00767 5 Recognition of dna damage by pcna containing replication complex 0.3112863515127607 0.3826264387385826 0.7019967641232796 1.0 1.0 19 P56282,O94782,P15927,P27694 4 Translesion synthesis by polk 0.3783429202970088 0.3811802347451158 0.7030695143773382 1.0 1.0 9 P15927,P27694 2 Auf1 hnrnp d0 binds and destabilizes mrna 0.2731320993933397 0.377260446311185 0.705980063447526 1.0 1.0 42 Q14103,Q14997,P28072,P60900,O75832,P20618,P11940,P49721,Q92530 9 Mapk3 erk1 activation 0.5809518665510672 0.3756851131425134 0.7071510065179649 1.0 1.0 4 P06493 1 P75 ntr receptor mediated signalling 0.3022185341483343 0.3636774578881291 0.7160988783382414 1.0 1.0 21 P42575,Q9NQC3,P61586,P78536 4 Metabolism of nucleotides 0.2585996185342631 0.356339878405917 0.721586048073243 1.0 1.0 49 Q9H773,Q9NRF8,P35754,P49902,Q06203,Q02127,P17812,Q9Y3Z3,P30520,P23921,Q16881,P55263,P00390,P04818,Q9H0P0 15 Rhog gtpase cycle 0.2738223747337771 0.353472572772188 0.7237341871436827 1.0 1.0 38 O15498,P50402,P42166,O15173,Q86XL3 5 Er quality control compartment erqc 0.5714443738820867 0.3492975534881635 0.7268659349606357 1.0 1.0 4 Q9GZP9 1 Tnfr2 non canonical nf kb pathway 0.2691798615432195 0.3450946398103935 0.7300232230288415 1.0 1.0 42 O15111,Q14997,P28072,P60900,O75832,P20618,P49721,Q92530 8 Dectin 1 mediated noncanonical nf kb signaling 0.2691798615432195 0.3450946398103935 0.7300232230288415 1.0 1.0 42 O15111,Q14997,P28072,P60900,O75832,P20618,P49721,Q92530 8 Mismatch repair 0.3336712947999441 0.3436178848745316 0.731133672674122 1.0 1.0 12 P20585,P15927,P18858,P27694 4 Negative regulation of fgfr1 signaling 0.4052284736050843 0.3433286621410382 0.7313512205172787 1.0 1.0 6 P28482 1 Negative regulation of fgfr2 signaling 0.4052284736050843 0.3433286621410382 0.7313512205172787 1.0 1.0 6 P28482 1 Spry regulation of fgf signaling 0.4052284736050843 0.3433286621410382 0.7313512205172787 1.0 1.0 6 P28482 1 Negative regulation of fgfr3 signaling 0.4052284736050843 0.3433286621410382 0.7313512205172787 1.0 1.0 6 P28482 1 Negative regulation of fgfr4 signaling 0.4052284736050843 0.3433286621410382 0.7313512205172787 1.0 1.0 6 P28482 1 Signaling by vegf 0.2875334549460145 0.3374374560046812 0.7357871528223745 1.0 1.0 26 P61586,P46108,Q9UQB8 3 Response to elevated platelet cytosolic ca2 0.2806857987381397 0.3321642218431107 0.7397652582587422 1.0 1.0 30 P37802,Q6UXV4,O75083,Q9NTK5,Q9NUQ9,Q9UNF1,Q01518,P04075,Q8NBX0,Q92520,P07602,O43707,O43852,O94919,Q9NZJ7 15 Regulation of lipid metabolism by pparalpha 0.2896919960657166 0.3274081722714891 0.7433591862100204 1.0 1.0 23 O75376,Q15067,P23786,Q86X55 4 Interleukin 12 family signaling 0.27976656673326 0.3259106838316364 0.7444919321317918 1.0 1.0 30 P52597,Q99439,Q13126,O00170,P07237,O14979,P22626,Q9H3K6 8 Signaling by interleukins 0.2449473401658145 0.3234290978219671 0.7463702958300924 1.0 1.0 111 Q99439,P28482,P22626,O75832,Q06124,Q13126,O15111,P09601,P60900,P46108,P27824,Q13501,P49721,P62191,P60953,P28066,P04083,O00170,P07237,Q16658,P28072,Q16539,P20618,P04637,P42574,Q92530,P52597,Q14997,O14979,P09429,Q9H3K6 31 Toll like receptor tlr1 tlr2 cascade 0.2948951750037969 0.3197071484129589 0.7491903403348126 1.0 1.0 21 P09429,O15111 2 Prolactin receptor signaling 0.5723378210888663 0.3185210934940989 0.7500896968891904 1.0 1.0 3 Q06124 1 The role of gtse1 in g2 m progression after g2 checkpoint 0.2575421663871092 0.3119857478687585 0.7550513546903923 1.0 1.0 47 P06493,Q14997,P28072,P60900,O75832,Q92530,P20618,P04637,P49721,O95067,P62191 11 Rnd1 gtpase cycle 0.3207389532523276 0.3098285806649385 0.7566913161167594 1.0 1.0 13 P51648 1 Rac2 gtpase cycle 0.267229088939976 0.2980086013534441 0.7656965988043911 1.0 1.0 36 Q13505,Q86Y07,P50402,P42166,Q14739,O15173,Q86XL3 7 Metabolism of cofactors 0.4526347171365575 0.2883808490935035 0.7730552255515799 1.0 1.0 5 P00374 1 Interleukin 1 family signaling 0.2461175452224416 0.287025280909009 0.7740929629255195 1.0 1.0 51 O15111,Q14997,P28072,P09429,P60900,O75832,Q06124,P20618,Q13501,P49721,Q92530,P62191 12 Switching of origins to a post replicative state 0.2457136702509612 0.2810229350919772 0.7786928087321892 1.0 1.0 59 P20618,Q9UBD5,Q14997,P28072,P60900,P49721,O75832,Q14566,Q9Y619,Q92530,P62191 11 Inactivation of cdc42 and rac1 0.5554121258054187 0.2756826429060373 0.7827918281614681 1.0 1.0 3 P60953 1 Dna replication pre initiation 0.245556718153075 0.2710463774131657 0.7863553628148607 1.0 1.0 67 P20618,Q9UBD5,Q14997,P28072,P60900,P49721,P56282,O75832,Q7L590,Q14566,Q9Y619,Q92530,P15927,O00311 14 Regulation of bach1 activity 0.5528485211476153 0.2694759798564085 0.7875634240721889 1.0 1.0 3 Q13309 1 Piwi interacting rna pirna biogenesis 0.3698916156534887 0.2639481664886057 0.7918198597911925 1.0 1.0 7 Q8N2A8 1 Rho gtpases activate paks 0.3148267164700086 0.2593323730704773 0.7953788034642253 1.0 1.0 12 P60953,P60660,P63000 3 Metabolism of polyamines 0.2597348099282621 0.2538246967499638 0.799630992885092 1.0 1.0 39 P19623,Q14997,P28072,P60900,O75832,P20618,P49721,Q92530 8 Ctla4 inhibitory signaling 0.3547782635852551 0.2525181987141802 0.800640549250691 1.0 1.0 8 P30154,Q16537,Q14738,Q06124,P07948,P30153,P31751 7 Small interfering rna sirna biogenesis 0.5441222326161392 0.248922256035143 0.8034209192232835 1.0 1.0 3 Q15631,Q99598 2 Regulation of mecp2 expression and activity 0.3062943607473626 0.245235473272373 0.8062741111179701 1.0 1.0 13 Q14739,Q9HCE1 2 Toll like receptor 9 tlr9 cascade 0.2786709807564138 0.2440035386936657 0.8072280792607083 1.0 1.0 22 P09429,O15111 2 Nuclear receptor transcription pathway 0.5295205036489496 0.2436941978547531 0.807467667364776 1.0 1.0 4 O75376 1 Synthesis of dna 0.2361089157899759 0.241485190551691 0.8091790931345675 1.0 1.0 85 O75832,P18858,Q9UBD5,P60900,P27694,P49642,Q14566,P49721,Q9Y619,P15927,Q9UJX4,P62191,P28066,O43913,P28072,Q9H1A4,P20618,P40938,Q92530,Q14997,Q14181,P51530,P39748,P56282 24 Iron uptake and transport 0.2895065271077389 0.2414814775580682 0.8091819705429006 1.0 1.0 18 P30519 1 Regulation of pten localization 0.5394512570662153 0.2382901349557138 0.8116560721772925 1.0 1.0 3 Q93009 1 Metabolism of lipids 0.3007063699907877 0.2298539302056405 0.8182052762033787 1.0 1.0 191 Q8N2A8,Q14534,Q16850,P33527,Q06136,Q9NQZ5,Q9H7Z7,O95470,Q96N66,Q8NF37,O75845,P27544,P40939,Q10713,Q16739,Q96G23,Q13510,P67870,Q15800,Q14739,Q15067,O00767,P23786,O43772,P62136,P04062,P38435,Q08426,P35610,P07602,P30536,Q14914,Q15392,P51648,O43681,O15254,O15121,O75376,Q9P035,Q15185,Q86X55 41 Caspase activation via extrinsic apoptotic signalling pathway 0.5224359599127878 0.2277214926277815 0.8198627626855588 1.0 1.0 4 P42574,Q9UKG1 2 Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s 0.2363774609018164 0.2252353776695002 0.8217961690377149 1.0 1.0 52 Q13347,O75822,P62266,P62753,P25398,P62273,P62263,P11940,P46782,P15880 10 Regulation of pten stability and activity 0.2508088058331218 0.223593834808303 0.82307336133589 1.0 1.0 44 Q14997,P28072,P60900,O75832,P67870,P20618,P49721,Q92530 8 Cooperation of prefoldin and tric cct in actin and tubulin folding 0.2965152288150506 0.223106873244961 0.823452329098443 1.0 1.0 14 P61758 1 Nuclear signaling by erbb4 0.4279761614114526 0.2211121729600006 0.8250050921774958 1.0 1.0 5 P78536 1 Deadenylation dependent mrna decay 0.2544516441644157 0.2175427456820699 0.8277853982826016 1.0 1.0 39 Q9NZN8,Q6PGP7 2 Cellular response to hypoxia 0.253724251008153 0.2167955208557003 0.8283677027909921 1.0 1.0 40 Q9GZT9,Q14997,P28072,P60900,O75832,P20618,P49721,Q92530,P62191 9 Fc epsilon receptor fceri signaling 0.23559795664664 0.2146309718854555 0.8300550445565495 1.0 1.0 53 O15111,Q14997,P28482,P63000,P28072,P60900,O75832,P20618,P49721,Q92530,P62191 11 Signaling by fgfr4 0.3543552919138212 0.2143775980493747 0.8302526097477232 1.0 1.0 7 P28482,P22681,Q06124,P19174,P62993,P30153 6 Signaling by fgfr1 0.3543552919138212 0.2143775980493747 0.8302526097477232 1.0 1.0 7 P28482,P22681,Q06124,P19174,P62993,P30153 6 Signaling by fgfr3 0.3543552919138212 0.2143775980493747 0.8302526097477232 1.0 1.0 7 P28482,P22681,Q06124,P19174,P62993,P30153 6 Gap filling dna repair synthesis and ligation in gg ner 0.2801709262728902 0.2126987881220985 0.8315619120754623 1.0 1.0 19 P56282,P15927,P18858,P27694 4 Downstream signaling events of b cell receptor bcr 0.24967772586801 0.2073328886724296 0.8357498906948719 1.0 1.0 43 O15111,Q14997,P28072,P60900,O75832,P20618,P49721,Q92530 8 Signaling by hedgehog 0.2359613894234695 0.2064260630145457 0.83645811387416 1.0 1.0 56 Q14997,P07237,P28072,P60900,O75832,Q9GZP9,P78536,P20618,P49721,Q92530,P62191 11 Linoleic acid la metabolism 0.5240522423874212 0.2051094436409573 0.8374866183324348 1.0 1.0 3 O95864 1 Pi5p regulates tp53 acetylation 0.5238450702762608 0.2046828933524813 0.8378198865719584 1.0 1.0 3 P04637 1 Regulation of cholesterol biosynthesis by srebp srebf 0.2640471174415318 0.2035269440960728 0.8387231880292967 1.0 1.0 27 Q14534,O75845,Q16850,Q86X55,O00767 5 Synthesis of udp n acetyl glucosamine 0.5229641441818824 0.2028750822471774 0.8392326707591287 1.0 1.0 3 Q06210 1 Fceri mediated nf kb activation 0.2459165630027286 0.1981505069226334 0.8429273093629002 1.0 1.0 45 O15111,Q14997,P28072,P60900,O75832,P20618,P49721,Q92530 8 Copi dependent golgi to er retrograde traffic 0.2428450468461528 0.19753945539708 0.8434054087337115 1.0 1.0 47 Q07866,P62820,P24390,Q9Y3B3,O14579,O00139,O15260,Q9P2W9,Q12981 9 Diseases of signal transduction by growth factor receptors and second messengers 0.2645924791393299 0.1955351375964805 0.8449740327083197 1.0 1.0 148 Q9HC35,Q96PU8,P28482,P63000,Q16630,P49589,O75832,P30086,P06753,Q86WB0,Q63HN8,O15111,P62753,P60900,Q9UBW7,Q09161,Q6WCQ1,Q13501,Q9NRY5,P49721,P62191,P49840,P28072,Q13363,P20618,P49841,Q92530,Q16543,Q14997,Q07866,O95352,O75376,O94979,P78536,Q9GZP9 35 Constitutive signaling by aberrant pi3k in cancer 0.5062365316277354 0.1933749562465294 0.8466653272794629 1.0 1.0 4 P63000 1 Synthesis of substrates in n glycan biosythesis 0.289308655215264 0.193326125429093 0.8467035671250365 1.0 1.0 14 Q06210,Q9UJ70,Q8NFW8,Q9NR45 4 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0.4148088976615097 0.1887719494011581 0.850271557680607 1.0 1.0 5 Q99808 1 Regulation of mrna stability by proteins that bind au rich elements 0.2355857894816887 0.1886518311273358 0.8503657067556327 1.0 1.0 62 Q14103,Q14997,P28072,P60900,Q01105,O75832,Q16539,P20618,P11940,Q92945,P49721,Q92530 12 Ksrp khsrp binds and destabilizes mrna 0.2970683092171564 0.1882220455777378 0.8507025914647866 1.0 1.0 12 Q15024,Q9NPD3,Q9NQT5,Q16539,Q9Y2L1,Q92945 6 Golgi to er retrograde transport 0.2357262993511287 0.1868364289893954 0.8517888836076137 1.0 1.0 71 P68402,P63167,Q9UJW0,Q07866,Q8N6T3,P62820,P35606,P24390,Q13409,O14579,O00139,Q9Y3B3,O15260,Q9P2W9,P43034,Q12981,Q10472 17 Glyoxylate metabolism and glycine degradation 0.2902829982717704 0.1804758826134499 0.8567789863967279 1.0 1.0 13 P11182 1 Activated tak1 mediates p38 mapk activation 0.4989564146727163 0.1789480436935634 0.8579784981774967 1.0 1.0 4 Q16539 1 Negative regulation of the pi3k akt network 0.2941473886351784 0.1773754982276972 0.8592134517318448 1.0 1.0 12 P28482,P63000,Q16537,Q06124 4 Uch proteinases 0.2363542105239641 0.1760450276225523 0.8602585678901298 1.0 1.0 49 Q14997,P28072,P60900,O75832,Q9H981,P20618,P49721,Q92530,P25490,Q9Y4E8 10 Erythropoietin activates phospholipase c gamma plcg 0.4650872817955193 0.1691353619928932 0.8656901707528861 1.0 1.0 2 P19174 1 Golgi cisternae pericentriolar stack reorganization 0.2906545958257671 0.1647357780780096 0.8691519548552595 1.0 1.0 12 P62820,O95067,P06493 3 Interleukin 17 signaling 0.2727615090899533 0.1638900071944545 0.8698177338360034 1.0 1.0 18 P63208,O15111,O43318,P28482,Q16539 5 Semaphorin interactions 0.2748958551107632 0.1625199608022955 0.870896410781826 1.0 1.0 17 P60660,P49841,P61586 3 Cross presentation of soluble exogenous antigens endosomes 0.2461962611040337 0.1608082424557283 0.8722444331885877 1.0 1.0 37 Q14997,P28072,P60900,O75832,P20618,P49721,Q92530 7 Degradation of axin 0.2461962611040337 0.1608082424557283 0.8722444331885877 1.0 1.0 37 Q14997,P28072,P60900,O75832,P20618,P49721,Q92530 7 Tp53 regulates metabolic genes 0.2459306077477401 0.1500368918058072 0.8807355092303131 1.0 1.0 35 P14854,Q9HCE1,Q9NQ88,P13073,P00403,P04637,Q04917 7 Antigen processing cross presentation 0.225641335339451 0.139258392178638 0.8892459676752142 1.0 1.0 53 P10321,O15111,Q14997,P28072,P09429,P60900,P04439,O75832,Q92530,P20618,P49721,Q9UIQ6 12 Galactose catabolism 0.448254364089784 0.1382945278816786 0.8900076500748122 1.0 1.0 2 Q96G03 1 Rac1 gtpase cycle 0.2376608113120901 0.135823932550368 0.89196047094613 1.0 1.0 44 O15498,P50402,P42166,Q14739,Q9UQB8,P63167 6 Fbxw7 mutants and notch1 in cancer 0.4466957605985122 0.1356695735769389 0.8920825020475658 1.0 1.0 2 P63208 1 Degradation of dvl 0.2415994442516705 0.1352980087165102 0.8923762594169624 1.0 1.0 38 Q14997,P28072,P60900,O75832,P20618,P49721,Q92530 7 Scf skp2 mediated degradation of p27 p21 0.2401996682652299 0.1352898249377611 0.8923827296389557 1.0 1.0 41 P28072,P60900,P11802,O75832,P20618,P49721,Q92530 7 Polo like kinase mediated events 0.333710302991515 0.1339835438030734 0.8934155872400456 1.0 1.0 6 Q99640,O95067,Q5TKA1 3 Flt3 signaling 0.3868954758190268 0.1289990053513534 0.897358435867984 1.0 1.0 5 Q06124,P62993,P31751,P41240 4 Infection with mycobacterium tuberculosis 0.2695652757659282 0.1276237889263909 0.8984467042375692 1.0 1.0 15 P28482,P49840,Q63HN8,P00558 4 Response of mtb to phagocytosis 0.2695652757659282 0.1276237889263909 0.8984467042375692 1.0 1.0 15 P28482,P49840,Q63HN8,P00558 4 Formation of incision complex in gg ner 0.269501220889927 0.1273995946201434 0.8986241370727535 1.0 1.0 15 Q86WJ1,P54725,P27694,P23025,P15927,P09874 6 Tp53 regulates transcription of cell cycle genes 0.2659785168618754 0.1272002444446086 0.8987819119146412 1.0 1.0 17 Q9NZN8,Q99873,Q86X55 3 Enos activation 0.4767695665731126 0.1217428522909036 0.90310267441145 1.0 1.0 3 P35270,O75608 2 Regulation of runx2 expression and activity 0.2349628628945675 0.1195427358887948 0.9048453844164056 1.0 1.0 44 Q14997,P28072,P60900,O75832,P20618,P04150,P49721,Q92530,P62191 9 Oas antiviral response 0.4742750233863301 0.1181258073018366 0.9059679753361743 1.0 1.0 3 P21333,P61221 2 Clec7a dectin 1 signaling 0.2292528739041383 0.1168162787508536 0.9070056434958532 1.0 1.0 48 O15111,Q14997,P28072,P60900,O75832,P20618,P49721,Q92530 8 Apoptotic factor mediated response 0.317827037152662 0.1163259973123139 0.9073941825976825 1.0 1.0 7 P28482,Q9NR28,Q07021,P27361,P98170,P42574 6 Caspase activation via death receptors in the presence of ligand 0.433603491271829 0.115138317119436 0.9083354891778406 1.0 1.0 2 P49327 1 Regulation by c flip 0.433603491271829 0.115138317119436 0.9083354891778406 1.0 1.0 2 P49327 1 Mastl facilitates mitotic progression 0.4615402150361136 0.1149165315861803 0.908511281593011 1.0 1.0 4 P30154,P06493 2 Signaling by the b cell receptor bcr 0.2299372279237141 0.1117255555885233 0.911041015758932 1.0 1.0 47 O15111,Q14997,P28072,P60900,O75832,P20618,P49721,Q92530 8 Hdr through mmej alt nhej 0.3156415860131066 0.1113326752366488 0.911352545367898 1.0 1.0 7 P49916,Q92878,P39748,P18887,P49959,P09874 6 Signaling by notch1 pest domain mutants in cancer 0.2933057923500033 0.1098302873161281 0.9125439705371572 1.0 1.0 10 P78536 1 Glycerophospholipid biosynthesis 0.2371751468194113 0.1029906641448761 0.9179703804843806 1.0 1.0 35 Q9NQZ5,Q8N2A8,Q96N66,Q8NF37,P40939 5 Eph ephrin signaling 0.2405806361809854 0.1015949055631506 0.9190782232985284 1.0 1.0 31 P61586,Q92747 2 Regulation of ras by gaps 0.2351017273732746 0.1011673605949214 0.9194176062242972 1.0 1.0 39 Q14997,P28072,P60900,O75832,P20618,P49721,Q92530 7 Keratinization 0.3176664687459533 0.0998801679999878 0.9204394612510772 1.0 1.0 6 P14923,Q14574,P15924 3 Formation of the cornified envelope 0.3176664687459533 0.0998801679999878 0.9204394612510772 1.0 1.0 6 P14923,Q14574,P15924 3 Nuclear events stimulated by alk signaling in cancer 0.2690761202207737 0.0949561891314721 0.9243496256260102 1.0 1.0 12 Q9HC35,P62753,Q86WB0 3 Gaba receptor activation 0.3150233116837386 0.0947440036225735 0.924518165322433 1.0 1.0 6 P63218,Q9Y639 2 Myd88 independent tlr4 cascade 0.2448797819252193 0.0921252658642607 0.9265985145524602 1.0 1.0 23 P28482,Q16539,O15111,P09429 4 Nucleotide excision repair 0.219318958782981 0.0879935265410019 0.9298818212575648 1.0 1.0 51 Q9UNP9,P27694,P56282,Q9H981,P25490,P23025,Q9BT78,P15927,P18858,Q13098 10 Cyclin a cdk2 associated events at s phase entry 0.2291906148871245 0.0820196159252833 0.934631114756922 1.0 1.0 43 P28072,P60900,P11802,O75832,P20618,P49721,Q92530 7 Folding of actin by cct tric 0.2945034353529004 0.0816708381205613 0.9349084686764556 1.0 1.0 8 P50990,P50991,P78371,P48643,P49368,Q99832,P17987 7 Glycogen metabolism 0.2804978995003877 0.0764448415432101 0.9390651955596758 1.0 1.0 10 P35573,P46976,P46020 3 Snrnp assembly 0.2298501247907554 0.0743965819379688 0.9406948284864808 1.0 1.0 39 Q9BTX1,Q09161,Q16637,Q9NWZ8 4 Degradation of beta catenin by the destruction complex 0.2164953221106423 0.0712190747269157 0.943223400526784 1.0 1.0 51 Q14997,Q04726,P28072,P60900,O75832,Q13363,P20618,P49841,P49721,Q92530,P62191 11 Netrin 1 signaling 0.2776747926100048 0.0696799719877159 0.9444483830672524 1.0 1.0 10 P60953,P63000,Q16539 3 Pi metabolism 0.2484166768742589 0.0618712201521982 0.9506653865657856 1.0 1.0 15 Q9UBF8,Q9NTJ5,Q10713,Q9BTU6,Q01968 5 Gastrin creb signalling pathway via pkc and mapk 0.3444617784711343 0.0615399164834926 0.950929225874082 1.0 1.0 5 P28482,P51812,P27361,P62993 4 Asymmetric localization of pcp proteins 0.2272469741828665 0.0611430224981548 0.9512453062256732 1.0 1.0 38 Q14997,P28072,P60900,O75832,P20618,P49721,Q92530 7 Dna damage reversal 0.3432137285491364 0.0599733608417366 0.9521768514572916 1.0 1.0 5 Q9H1I8,Q8N9N2,Q8N3C0,Q6P6C2 4 Rhod gtpase cycle 0.2326256160313611 0.0583464394845792 0.9534726771357556 1.0 1.0 28 P42166,O15173,P50402 3 Degradation of the extracellular matrix 0.2651009847090875 0.0567323712261952 0.9547583870239388 1.0 1.0 11 P35613 1 Tcr signaling 0.2199123369090996 0.0555665537847804 0.9556871095335304 1.0 1.0 47 O15111,Q14997,P28072,P60900,O75832,P20618,P49721,Q92530 8 Phase 0 rapid depolarisation 0.3756234413965159 0.0541246267357909 0.9568358717038364 1.0 1.0 2 Q13557 1 Sars cov 1 infection 0.2490562702916128 0.0515296166896229 0.9589035024881152 1.0 1.0 13 Q10472,P49840,P49841,Q14457 4 Telomere c strand lagging strand synthesis 0.2357466716246966 0.0495798292131149 0.9604572208163912 1.0 1.0 22 P18858,Q14181,P51530,P27694,P39748,P40938,P15927 7 G0 and early g1 0.2869546879147454 0.048510211476975 0.9613096264424592 1.0 1.0 6 P06493,Q5TKA1 2 Josephin domain dubs 0.4044278141565313 0.0462410827754691 0.9631180981591734 1.0 1.0 3 P54727,P54725 2 Phospholipid metabolism 0.2152495419351451 0.0459956816110147 0.9633136918437536 1.0 1.0 49 Q9UG56,Q8N2A8,Q96N66,Q9BVG9,Q8NF37,Q9NQZ5,O96017,Q9UBF8,Q9NTJ5,P40939,Q10713,Q8IV08,P67870,Q9BTU6,Q01968,O75131,Q9NP80,Q8NCC3 18 Antigen presentation folding assembly and peptide loading of class i mhc 0.2410104480297318 0.0433024194450328 0.96546046259496 1.0 1.0 16 P10321,O95486,P01889,P04439,O94979,P27824,O95487,P53992 8 Signaling by tgf beta receptor complex 0.2360692338401409 0.041102250685394 0.9672143803340671 1.0 1.0 20 P61586,P62136,O75376 3 Ion channel transport 0.2290247547686394 0.0408833910035582 0.9673888584357428 1.0 1.0 27 P23634,P16615,Q9HD20 3 Thrombin signalling through proteinase activated receptors pars 0.3261638627661318 0.0408155572070457 0.9674429368360826 1.0 1.0 5 P28482,P63218 2 Rho gtpases activate formins 0.2132272654390793 0.0406255611320527 0.9675944061381652 1.0 1.0 60 P60953,P61586,P63167,O43684,Q53HL2,O75122,P63000,P35080,O00139,Q9P258,P43034,Q8NBT2 12 Transcriptional activity of smad2 smad3 smad4 heterotrimer 0.2686249870646482 0.0334758203424712 0.97329514759389 1.0 1.0 8 P28482,O75376 2 Pp2a mediated dephosphorylation of key metabolic factors 0.3638914873713731 0.0260971446837832 0.9791798545006408 1.0 1.0 3 Q14738,P30154 2 Dna replication 0.2055226857721904 0.0260106525701104 0.9792488418042912 1.0 1.0 92 O75832,Q7L590,P18858,Q9UBD5,P60900,P27694,P49642,Q14566,P49721,Q9Y619,P15927,Q9UJX4,P62191,O00311,P28066,O43913,P28072,Q9H1A4,P20618,P40938,Q92530,Q14997,Q14181,P51530,P39748,P56282 26 Signaling by tgfb family members 0.2298745751849093 0.025874409367022 0.979357511578123 1.0 1.0 21 P61586,P62136,O75376 3 Runx2 regulates osteoblast differentiation 0.353913314624259 0.0228930304418586 0.9817355998418632 1.0 1.0 3 P28482,P07947 2 Copi independent golgi to er retrograde traffic 0.2245078320646416 0.0225610461673118 0.9820004165675668 1.0 1.0 26 Q9UJW0,Q13409,Q10472,P43034,P68402,P63167 6 C type lectin receptors clrs 0.2071784480368332 0.0219164580624978 0.9825145962929528 1.0 1.0 51 O15111,Q14997,P28072,P60900,O75832,P20618,P49721,Q92530 8 Sema3a pak dependent axon repulsion 0.302964118564738 0.0209887079847888 0.9832546634157376 1.0 1.0 5 P07900,P63000,Q13177,P08238 4 Pecam1 interactions 0.3543356207111736 0.0184624822625671 0.985269907277904 1.0 1.0 4 Q06124,P19174,P07948 3 Runx2 regulates bone development 0.3540237055520959 0.0183341869362836 0.985372254814178 1.0 1.0 4 P28482,P07947,Q96PK6 3 Nef mediated downregulation of mhc class i complex cell surface expression 0.2942555279733128 0.0152078368871118 0.9878663694539478 1.0 1.0 5 P04439 1 Rsk activation 0.3443543356207167 0.0146749046927307 0.9882915403575736 1.0 1.0 4 P28482,P51812,P27361 3 Formyl peptide receptors bind formyl peptides and many other ligands 0.3068953131586339 0.0140858651617395 0.9887614773053326 1.0 1.0 3 P04083 1 Synthesis of diphthamide eef2 0.2881197380729678 0.0125287943036225 0.9900037299805772 1.0 1.0 3 P13639,Q9H2P9 2 Thromboxane signalling through tp receptor 0.2860261923439107 0.0123994252664193 0.9901069435203044 1.0 1.0 3 P63218 1 Jnk c jun kinases phosphorylation and activation mediated by activated human tak1 0.2609915809167515 0.0113430896512475 0.9909497179726692 1.0 1.0 3 Q15750,O43318 2 Metabolism of ingested semet sec mesec into h2se 0.2516370439663303 0.0111212035039938 0.9911267463360556 1.0 1.0 3 P23526,Q96I15 2 Signaling by notch1 0.2326016140187088 0.010702618465855 0.9914607089899063 1.0 1.0 12 P78536 1 Dna strand elongation 0.217994159448863 0.0067638523373976 0.9946032677982832 1.0 1.0 28 P18858,Q14181,P51530,P27694,P39748,Q14566,P40938,P15927 8 Role of phospholipids in phagocytosis 0.3059921557899634 0.0052058101384964 0.9958463832248514 1.0 1.0 4 Q8IV08,O43865 2 Estrogen dependent nuclear events downstream of esr membrane signaling 0.2947598253275155 0.0036013879554308 0.9971265143644176 1.0 1.0 4 P28482,P27361,P31751 3 Homologous dna pairing and strand exchange 0.2232101088922307 0.0035248913499877 0.9971875494373889 1.0 1.0 19 O14757,Q13535,P51530,P27694,P15927 5 Miro gtpase cycle 0.2645059095732769 0.0011212099482827 0.9991054040802811 1.0 1.0 5 Q8IWA4 1 Metabolic disorders of biological oxidation enzymes 0.262320648783533 0.0008501096140141 0.9993217107456864 1.0 1.0 4 P22570,P48506,P23526 3 Vitamin b5 pantothenate metabolism 0.2633385335413373 0.0007218223575202 0.9994240691353048 1.0 1.0 5 Q9NVE7,Q9NRN7,Q13057,P49327 4