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  1. interpro_active_site/advanced/idx2term.json +1 -0
  2. interpro_active_site/basic/idx2term.json +1 -0
  3. interpro_active_site/consensus.joblib +3 -0
  4. interpro_active_site/df_merge.tsv +1 -0
  5. interpro_active_site/metrics.json +7 -0
  6. interpro_active_site/paths.json +1 -0
  7. interpro_active_site/result.tsv +4 -0
  8. interpro_active_site/selections.json +1 -0
  9. interpro_binding_site/advanced/idx2term.json +1 -0
  10. interpro_binding_site/basic/idx2term.json +1 -0
  11. interpro_binding_site/basic/plot_0.png +3 -0
  12. interpro_binding_site/consensus.joblib +3 -0
  13. interpro_binding_site/df_merge.tsv +1 -0
  14. interpro_binding_site/metrics.json +7 -0
  15. interpro_binding_site/paths.json +1 -0
  16. interpro_binding_site/result.tsv +4 -0
  17. interpro_binding_site/selections.json +1 -0
  18. interpro_conserved_site/advanced/idx2term.json +1 -0
  19. interpro_conserved_site/basic/idx2term.json +1 -0
  20. interpro_conserved_site/basic/plot_0.png +3 -0
  21. interpro_conserved_site/consensus.joblib +3 -0
  22. interpro_conserved_site/df_merge.tsv +1 -0
  23. interpro_conserved_site/metrics.json +7 -0
  24. interpro_conserved_site/paths.json +1 -0
  25. interpro_conserved_site/result.tsv +28 -0
  26. interpro_conserved_site/selections.json +1 -0
  27. interpro_domain/advanced/idx2term.json +1 -0
  28. interpro_domain/advanced/plot_0.png +3 -0
  29. interpro_domain/basic/idx2term.json +1 -0
  30. interpro_domain/basic/plot_0.png +3 -0
  31. interpro_domain/basic/plot_1.png +3 -0
  32. interpro_domain/basic/plot_2.png +3 -0
  33. interpro_domain/basic/plot_3.png +3 -0
  34. interpro_domain/basic/plot_4.png +3 -0
  35. interpro_domain/basic/plot_5.png +3 -0
  36. interpro_domain/basic/plot_6.png +3 -0
  37. interpro_domain/basic/plot_7.png +3 -0
  38. interpro_domain/basic/plot_8.png +3 -0
  39. interpro_domain/basic/plot_9.png +3 -0
  40. interpro_domain/consensus.joblib +3 -0
  41. interpro_domain/df_merge.tsv +8 -0
  42. interpro_domain/metrics.json +7 -0
  43. interpro_domain/paths.json +1 -0
  44. interpro_domain/result.tsv +178 -0
  45. interpro_domain/selections.json +0 -0
  46. interpro_family/advanced/idx2term.json +1 -0
  47. interpro_family/advanced/plot_0.png +3 -0
  48. interpro_family/basic/idx2term.json +1 -0
  49. interpro_family/basic/plot_0.png +3 -0
  50. interpro_family/basic/plot_1.png +3 -0
interpro_active_site/advanced/idx2term.json ADDED
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+ {}
interpro_active_site/basic/idx2term.json ADDED
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+ {}
interpro_active_site/consensus.joblib ADDED
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+ size 60715
interpro_active_site/df_merge.tsv ADDED
@@ -0,0 +1 @@
 
 
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+ term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500
interpro_active_site/metrics.json ADDED
@@ -0,0 +1,7 @@
 
 
 
 
 
 
 
 
1
+ {
2
+ "type_of_task": "ranksum",
3
+ "signature_size": 2701,
4
+ "annotations_size": 52,
5
+ "title": "Average number of proteins per term",
6
+ "value": 2.3076923076923075
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+ }
interpro_active_site/paths.json ADDED
@@ -0,0 +1 @@
 
 
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+ {"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C423/C423_val_log2fc"}
interpro_active_site/result.tsv ADDED
@@ -0,0 +1,4 @@
 
 
 
 
 
1
+ Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size
2
+ Serine carboxypeptidase, serine active site [IPR018202] 0.8951074870274307 1.859807435121026 0.062912775071571 0.9659151882879128 0.4303288909523463 3 P10619,Q9HB40 2
3
+ Cysteine peptidase, cysteine active site [IPR000169] 0.8036309744349824 0.7508547309624363 0.4527400868070672 0.9999999999999756 0.8590813896827653 2 Q13867 1
4
+ Histidine acid phosphatase active site [IPR033379] 0.7491663579103455 0.5722639613401833 0.5671431610754443 1.0 0.8590813896827653 2 Q9NPH0 1
interpro_active_site/selections.json ADDED
@@ -0,0 +1 @@
 
 
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+ {"all_annotations": ["ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenosine/AMP deaminase active site [IPR006650]", "Adenylosuccinate synthase, active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Cysteine peptidase, cysteine active site [IPR000169]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Peptidase family C14A, His active site [IPR016129]", "Peptidase family C14A, cysteine active site [IPR033139]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine proteases, trypsin family, histidine active site [IPR018114]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADA", "ADSS", "AKT1", "APEH", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "BLMH", "CAMK1", "CAMK2G", "CAMK4", "CAPN1", "CASP2", "CASP6", "CASP8", "CDK1", "CDK4", "CDK9", "CIT", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLUD1", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "LDHA", "LDHB", "LONP1", "MAP2K1", "MAP2K2", "MAPK1", "MAPK3", "MDH1", "MDH2", "NME1", "NME2", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKN2", "PLK1", "PREP", "PRKACA", "PRPF4B", "PRSS3", "PTK7", "PTPN1", "PTPN11", "PTPRF", "RNASET2", "ROCK1", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SRPK2", "SUCLG1", "TALDO1", "TIGAR", "TOP1", "TPI1", "TPP2", "TXNRD1", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UMPS", "VRK1", "VRK2"], "leading_proteins": ["ACP6", "BLMH", "CTSA", "SCPEP1"]}
interpro_binding_site/advanced/idx2term.json ADDED
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+ {}
interpro_binding_site/basic/idx2term.json ADDED
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+ {"0": "EF-Hand 1, calcium-binding site [IPR018247]"}
interpro_binding_site/basic/plot_0.png ADDED

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interpro_binding_site/consensus.joblib ADDED
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interpro_binding_site/df_merge.tsv ADDED
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+ term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500
interpro_binding_site/metrics.json ADDED
@@ -0,0 +1,7 @@
 
 
 
 
 
 
 
 
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+ {
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+ "type_of_task": "ranksum",
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+ "signature_size": 2701,
4
+ "annotations_size": 27,
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+ "title": "Average number of proteins per term",
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+ "value": 4.296296296296297
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+ }
interpro_binding_site/paths.json ADDED
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+ {"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C423/C423_val_log2fc"}
interpro_binding_site/result.tsv ADDED
@@ -0,0 +1,4 @@
 
 
 
 
 
1
+ Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size
2
+ EF-Hand 1, calcium-binding site [IPR018247] 0.4251549873941769 1.473938517645722 0.1404981458020822 0.9832249399316826 0.3675649084693859 31 P31949,Q9H223,Q14257,Q9Y680,Q9NWM8,O75340,P07384,P80303,Q6NUK1,O95202,Q02818 11
3
+ Peptidase M16, zinc-binding site [IPR001431] 0.6895752431351514 1.459897675604284 0.1443181981611632 0.9851258558722584 0.3675649084693859 5 Q10713,O43847 2
4
+ Hexokinase, binding site [IPR019807] 0.5313078918117888 0.0909303924963587 0.927547900502354 1.0 0.929674089589773 2 P52789 1
interpro_binding_site/selections.json ADDED
@@ -0,0 +1 @@
 
 
1
+ {"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT1", "APEX1", "CALU", "CAMK1", "CAMK2G", "CAMK4", "CAPN1", "CDK1", "CDK4", "CDK9", "CIT", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DLAT", "DLST", "DST", "EHD4", "EIF2AK2", "EPS15", "FKBP10", "FKBP14", "FKBP7", "GCAT", "GOT1", "GOT2", "GPD2", "HK1", "HK2", "IDE", "ILKAP", "IQGAP1", "IQGAP2", "LETM1", "MACF1", "MAP2K1", "MAP2K2", "MAPK1", "MAPK14", "MAPK3", "MCCC1", "MICU1", "MYH10", "MYH14", "MYH9", "MYO1B", "MYO1C", "MYO1D", "NRDC", "NUCB1", "NUCB2", "PA2G4", "PAK2", "PC", "PCCA", "PDCD6", "PDHX", "PEF1", "PGD", "PKN2", "PLCG1", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1F", "PPM1G", "PRKACA", "PRKCSH", "PSAT1", "RAB18", "RCN1", "RCN2", "RHOT1", "RHOT2", "ROCK1", "RPS6KA1", "RPS6KA3", "S100A11", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "SRPK2", "STK26", "STK4", "TKT", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["CAPN1", "EHD4", "FKBP14", "FKBP7", "HK2", "LETM1", "NRDC", "NUCB1", "NUCB2", "PDCD6", "PMPCA", "RCN2", "S100A11", "SLC25A24"]}
interpro_conserved_site/advanced/idx2term.json ADDED
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+ {}
interpro_conserved_site/basic/idx2term.json ADDED
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+ {"0": "Mini-chromosome maintenance, conserved site [IPR018525]"}
interpro_conserved_site/basic/plot_0.png ADDED

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interpro_conserved_site/consensus.joblib ADDED
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interpro_conserved_site/df_merge.tsv ADDED
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+ term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500
interpro_conserved_site/metrics.json ADDED
@@ -0,0 +1,7 @@
 
 
 
 
 
 
 
 
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+ {
2
+ "type_of_task": "ranksum",
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+ "signature_size": 2701,
4
+ "annotations_size": 255,
5
+ "title": "Average number of proteins per term",
6
+ "value": 2.635294117647059
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+ }
interpro_conserved_site/paths.json ADDED
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+ {"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C423/C423_val_log2fc"}
interpro_conserved_site/result.tsv ADDED
@@ -0,0 +1,28 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size
2
+ Cadherin conserved site [IPR020894] 0.9474744860240346 2.3895767702988007 0.0168677981596863 0.9869370896245696 0.7230213851243259 4 Q08554 1
3
+ Sterol reductase, conserved site [IPR018083] 0.8998337569938366 1.878510138246399 0.0603114114626044 0.9999998709054282 0.7230213851243259 3 Q9UBM7 1
4
+ Proteasome beta-type subunit, conserved site [IPR016050] 0.7210711547209285 1.8150733701456867 0.0695126349508878 0.9999999895004068 0.7230213851243259 8 Q99436,P28070,P49721,P28072 4
5
+ Thioredoxin, conserved site [IPR017937] 0.7004335053338151 1.781744659596766 0.0747908804989809 0.9999999975386368 0.7230213851243259 10 Q9H3N1,Q9H1E5,O95881 3
6
+ Syntaxin/epimorphin, conserved site [IPR006012] 0.734792284866455 1.6620621631956805 0.0965003110603823 0.9999999999942238 0.7230213851243259 5 Q12846,Q9P2W9,Q13190,O15400 4
7
+ Intermediate filament protein, conserved site [IPR018039] 0.6585772203806199 1.5130364520077235 0.1302703998831311 0.9999999999999996 0.7458120674408172 8 P02545,Q16352 2
8
+ Tetraspanin, conserved site [IPR018503] 0.9592441645053728 1.3107337539564314 0.1899477306632127 1.0 0.8806667512567133 2 O60637 1
9
+ Clathrin adaptor, mu subunit, conserved site [IPR018240] 0.677909562638994 0.9850923107169336 0.3245787299988292 1.0 0.9314577017047094 3 Q96CW1,Q9BXS5 2
10
+ ABC transporter-like, conserved site [IPR017871] 0.5426829582929379 0.9580140113864424 0.3380556932959797 1.0 0.9314577017047094 9 O15439,P08183,P33527,O75027 4
11
+ Oxysterol-binding protein, conserved site [IPR018494] 0.5728477572157208 0.9318648130838704 0.3514063941499998 1.0 0.9314577017047094 5 Q9H4L5,Q96SU4 2
12
+ Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726] 0.8114116339385036 0.7774465903849402 0.4368953338104619 1.0 0.9314577017047094 2 Q16611 1
13
+ Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728] 0.8114116339385036 0.7774465903849402 0.4368953338104619 1.0 0.9314577017047094 2 Q16611 1
14
+ Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717] 0.8114116339385036 0.7774465903849402 0.4368953338104619 1.0 0.9314577017047094 2 Q16611 1
15
+ Annexin repeat, conserved site [IPR018252] 0.5100510142462124 0.7565969619797072 0.4492913619987422 1.0 0.9314577017047094 6 P20073,P07355 2
16
+ Phosphatidylinositol 3/4-kinase, conserved site [IPR018936] 0.424175009269562 0.2689683535226783 0.7879540357688151 1.0 1.0 4 P78527,P42356,P42345 3
17
+ Mini-chromosome maintenance, conserved site [IPR018525] 0.3870129870129821 0.2337374309673706 0.815188826819599 1.0 1.0 6 P33993,P33992,P25205,Q14566,P49736 5
18
+ Glycoside hydrolase, family 29, conserved site [IPR018526] 0.6168951463505032 0.2241807998096752 0.8226166228146905 1.0 1.0 2 Q9BTY2 1
19
+ Clathrin adaptor complex, small chain [IPR000804] 0.4558932542624218 0.2238134108807851 0.8229024942917966 1.0 1.0 3 P61923,P53680 2
20
+ Ras GTPase-activating protein, conserved site [IPR023152] 0.4329132690882202 0.1717789274646413 0.8636113327004358 1.0 1.0 3 P46940,P21359 2
21
+ Phosphorylase pyridoxal-phosphate attachment site [IPR035090] 0.5879955539088595 0.1703225915317366 0.8647564453621979 1.0 1.0 2 P06737 1
22
+ Ribosomal protein L7Ae conserved site [IPR004037] 0.5665061133753293 0.1361602095270745 0.8916946303472415 1.0 1.0 2 P55769 1
23
+ Aldehyde dehydrogenase, cysteine active site [IPR016160] 0.3375928742624999 0.0726876632721175 0.9420546658619962 1.0 1.0 7 P51648 1
24
+ Ribosomal protein S2, conserved site [IPR018130] 0.479436828454986 0.0465245426940603 0.962892173021786 1.0 1.0 2 Q9Y399 1
25
+ DnaJ domain, conserved site [IPR018253] 0.3229907800360029 0.034759711112591 0.972271347077494 1.0 1.0 7 Q96KC8,Q9NVH1 2
26
+ Profilin conserved site [IPR027310] 0.4020007410151888 0.0169617746659409 0.9864671107794374 1.0 1.0 2 P35080 1
27
+ Aldehyde dehydrogenase, glutamic acid active site [IPR029510] 0.3132743830205499 0.0120523949553563 0.990383812953234 1.0 1.0 7 P51648 1
28
+ Vinculin, conserved site [IPR000633] 0.3486476472767715 0.0108701046776729 0.9913270821011816 1.0 1.0 2 P18206 1
interpro_conserved_site/selections.json ADDED
@@ -0,0 +1 @@
 
 
1
+ {"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Anion exchange, conserved site [IPR018241]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific, conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Deoxyribonuclease, TatD-related, conserved site [IPR018228]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dynamin, GTPase region, conserved site [IPR019762]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Endonuclease III-like, conserved site-2 [IPR004036]", "Endonuclease III-like, iron-sulphur cluster loop motif [IPR003651]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Fibrillarin, conserved site [IPR020813]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif [IPR000445]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P, conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium/solute symporter, conserved site [IPR018212]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor, T-box, conserved site [IPR018186]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]"], "available_proteins": ["AAAS", "AAMP", "ABCB1", "ABCB7", "ABCC1", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADS", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "AP3S1", "APEX1", "ARIH2", "ATAD1", "ATAD2", "ATP5C1", "ATP5O", "BAG6", "BAK1", "BAZ1A", "BAZ1B", "BAZ2A", "BCR", "BCS1L", "BOP1", "BPTF", "BRD2", "BRD4", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBR1", "CBX1", "CBX3", "CBX5", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDH2", "CDKAL1", "CHAF1B", "CHD1", "CHD1L", "CHD4", "CLGN", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "CORO1B", "CORO1C", "CPOX", "CRYZ", "CSTB", "CSTF1", "CTBP1", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYP51A1", "DCAF13", "DCAF7", "DCPS", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX30", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIS3", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC1", "DNAJC11", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNM3", "DNMT1", "DRG1", "DRG2", "DSC1", "DSC3", "DSG2", "DST", "DTYMK", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EHHADH", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPRS", "EPS15", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FBL", "FDFT1", "FDPS", "FEN1", "FLNA", "FLNB", "FLNC", "FUCA1", "FUCA2", "GAA", "GALK1", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GMPPB", "GNPDA1", "GNS", "GPI", "GRHPR", "GRWD1", "GSPT1", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HLA-A", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSD17B8", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "ILVBL", "IMPAD1", "IMPDH2", "INA", "IQGAP1", "IQGAP2", "IVD", "KDM2A", "KDM5A", "KDSR", "KIF11", "KIF14", "KIF18B", "KIF1A", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "LAMP1", "LARS", "LARS2", "LBR", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK14", "MAPK3", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME2", "MGA", "MGST2", "MID1", "MIF", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPST", "MRPL13", "MRPL3", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NEFL", "NEFM", "NES", "NF1", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD2", "NSD3", "NSF", "NTHL1", "NUBP2", "NUDT1", "NUDT12", "NUDT5", "NUP153", "NUP37", "NVL", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PHF2", "PHF3", "PHGDH", "PHIP", "PHRF1", "PI4KA", "PIK3C2A", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PNP", "POLA1", "POLD1", "POLR1B", "POLR2B", "POLR2E", "PPIB", "PPID", "PPIF", "PPIH", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS2", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RBBP4", "RCL1", "RDH13", "RDX", "RIDA", "RNF14", "RNF2", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSF1", "S100A10", "S100A11", "SART1", "SCD", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A4", "SLC2A1", "SLC4A2", "SLC5A6", "SLIT2", "SMARCA4", "SMU1", "SNRNP40", "SNU13", "SORD", "SPATA5", "SPTBN1", "SPTBN2", "SRCAP", "SRM", "STAM", "STMN1", "STX12", "STX18", "STX4", "STX5", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SYNE2", "TATDN1", "TBL3", "TCP1", "TFB1M", "THOC6", "TK1", "TLN1", "TM7SF2", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM21", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TRMT11", "TSFM", "TSPAN3", "TSPAN6", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB4A", "TUBB4B", "TUBB6", "TUBG1", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UBFD1", "UHRF1", "USP10", "USP14", "USP24", "USP28", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VAT1", "VCL", "VCP", "VIM", "VPS4A", "WARS", "WARS2", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZMYND8"], "leading_proteins": ["ABCB1", "ABCB7", "ABCC1", "ABCC4", "ALDH3A2", "ANXA2", "ANXA7", "AP1M1", "AP2M1", "AP2S1", "BAK1", "COPZ1", "DHCR7", "DNAJC1", "DNAJC11", "DSC1", "FUCA2", "INA", "IQGAP1", "LMNA", "MCM2", "MCM3", "MCM5", "MCM6", "MCM7", "MRPS2", "MTOR", "NF1", "OSBPL3", "OSBPL9", "PFN2", "PI4KA", "PRKDC", "PSMB2", "PSMB4", "PSMB6", "PSMB7", "PYGL", "SNU13", "STX18", "STX4", "STX5", "STX7", "TMX1", "TMX4", "TSPAN3", "TXNDC12", "VCL"]}
interpro_domain/advanced/idx2term.json ADDED
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+ {"0": "GOLD domain [IPR009038]"}
interpro_domain/advanced/plot_0.png ADDED

Git LFS Details

  • SHA256: 67741818cb60b12e0451b73d2a41009a4ad946a30ac38f5621866012d35dafba
  • Pointer size: 131 Bytes
  • Size of remote file: 179 kB
interpro_domain/basic/idx2term.json ADDED
@@ -0,0 +1 @@
 
 
1
+ {"0": "GOLD domain [IPR009038]", "1": "Target SNARE coiled-coil homology domain [IPR000727]", "2": "EF-hand domain [IPR002048]", "3": "Small GTP-binding protein domain [IPR005225]", "4": "Importin-beta, N-terminal domain [IPR001494]", "5": "TGS [IPR004095]", "6": "MCM domain [IPR001208]", "7": "MCM OB domain [IPR033762]", "8": "MCM, AAA-lid domain [IPR041562]", "9": "MCM N-terminal domain [IPR027925]"}
interpro_domain/basic/plot_0.png ADDED

Git LFS Details

  • SHA256: 7acb4c31be413975196891cc485caed96fe8b12c5b8e085579c1e6b71e249ed6
  • Pointer size: 131 Bytes
  • Size of remote file: 130 kB
interpro_domain/basic/plot_1.png ADDED

Git LFS Details

  • SHA256: ca4b2689b297ce514c261266dc856bcdc22b301bc2e39a0039a5254d7e02e956
  • Pointer size: 131 Bytes
  • Size of remote file: 140 kB
interpro_domain/basic/plot_2.png ADDED

Git LFS Details

  • SHA256: d1487951195f05ab4f0960667548410d18ca16d38cd2abc8a24bc03c5aee38ef
  • Pointer size: 131 Bytes
  • Size of remote file: 137 kB
interpro_domain/basic/plot_3.png ADDED

Git LFS Details

  • SHA256: cc60806ebd065e8c8bb777c717bae6c5a2b0062887f4151c4d3a3d290110da4c
  • Pointer size: 131 Bytes
  • Size of remote file: 151 kB
interpro_domain/basic/plot_4.png ADDED

Git LFS Details

  • SHA256: ce3755e001ebf28e98484f205cb698e2bdd4c213f2c82cfa0208f9e82d811584
  • Pointer size: 131 Bytes
  • Size of remote file: 145 kB
interpro_domain/basic/plot_5.png ADDED

Git LFS Details

  • SHA256: 50f82974e8a7616c478a8ab0fddefaf0a1d5e56d47c44a489b3d1979c8da1138
  • Pointer size: 131 Bytes
  • Size of remote file: 128 kB
interpro_domain/basic/plot_6.png ADDED

Git LFS Details

  • SHA256: 79b2945939c6e67636023e039bdda73a7630d5fecfecd3bb2a2803981a92780d
  • Pointer size: 131 Bytes
  • Size of remote file: 131 kB
interpro_domain/basic/plot_7.png ADDED

Git LFS Details

  • SHA256: 61bfeffe2f843cfaf7e12af2584bce20696af9526149019e1da854c5127a681f
  • Pointer size: 131 Bytes
  • Size of remote file: 133 kB
interpro_domain/basic/plot_8.png ADDED

Git LFS Details

  • SHA256: 3ba0bcbe6d2b9efd00480bbd9f7dcfd026bbe81de379d09eb96d961877dbe7d1
  • Pointer size: 131 Bytes
  • Size of remote file: 134 kB
interpro_domain/basic/plot_9.png ADDED

Git LFS Details

  • SHA256: 9efa8fe952c062fe818da637cba6f75df7da5ef7cc4eab2e5072699362f82f7b
  • Pointer size: 131 Bytes
  • Size of remote file: 134 kB
interpro_domain/consensus.joblib ADDED
@@ -0,0 +1,3 @@
 
 
 
 
1
+ version https://git-lfs.github.com/spec/v1
2
+ oid sha256:a45a7d83afa744badb9f36926e444a81213c2cdc9065993ca34f089e113ac4d2
3
+ size 103389
interpro_domain/df_merge.tsv ADDED
@@ -0,0 +1,8 @@
 
 
 
 
 
 
 
 
 
1
+ term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500
2
+ P-type ATPase, haloacid dehalogenase domain [IPR044492] 3 7 2.293800546131534 0.0218019580495594 2.941747572815534 6.145631067961165 0.9567723497044874 0.2732808833570771 1.8358630293390923 1.459204245106796 1.2102525517005158 0.2943240638910574 1.0 0.1791683947223221 0.0923651523277603 0.0190815744188786
3
+ GOLD domain [IPR009038] 5 7 2.245526607494753 0.0247343460909081 2.8762135922330097 6.247572815533981 0.4192390492462461 0.3068843884052658 1.4199402534298398 0.930533270242389 1.3963570929114475 0.294203492723015 1.0 1.0 0.0357281213139523 1.5003179712447913e-05
4
+ Aminopeptidase N-like , N-terminal domain [IPR045357] 3 5 2.1618146352445766 0.0306324669435797 2.121359223300971 5.466019417475728 1.4317001483019938 0.1783942022754649 1.021530403905949 0.5881604361499402 0.986353205880356 0.2226891741813114 0.0324938761136567 0.069232559208001 0.000644869377708 0.0003110572925293
5
+ Peptidase M1, membrane alanine aminopeptidase [IPR014782] 3 5 2.1618146352445766 0.0306324669435797 2.121359223300971 5.466019417475728 1.4317001483019938 0.1783942022754649 1.021530403905949 0.5881604361499402 0.986353205880356 0.2226891741813114 0.0324938761136567 0.069232559208001 0.000644869377708 0.0003110572925293
6
+ ABC transporter type 1, transmembrane domain [IPR011527] 4 5 2.055246042882419 0.0398552460026762 2.3689320388349513 6.349514563106796 0.6640264147492347 0.3307390797434538 1.7803691733569 2.1393617497725477 1.1694677427725269 0.279101120079799 1.0 1.0 0.2985003936931993 0.0004953322211988
7
+ Cation-transporting P-type ATPase, C-terminal [IPR006068] 2 5 1.994347926109533 0.0461140451027428 2.2985436893203883 4.150485436893204 0.5310155053290574 0.3897464493012307 1.1928988171245156 0.7984662222288074 1.1360507856968378 0.3059467081218019 1.0 1.0 0.2104545931454787 0.0101613445639074
8
+ Cation-transporting P-type ATPase, N-terminal [IPR004014] 2 5 1.994347926109533 0.0461140451027428 2.2985436893203883 4.150485436893204 0.5310155053290574 0.3897464493012307 1.1928988171245156 0.7984662222288074 1.1360507856968378 0.3059467081218019 1.0 1.0 0.2104545931454787 0.0101613445639074
interpro_domain/metrics.json ADDED
@@ -0,0 +1,7 @@
 
 
 
 
 
 
 
 
1
+ {
2
+ "type_of_task": "ranksum",
3
+ "signature_size": 2701,
4
+ "annotations_size": 2337,
5
+ "title": "Average number of proteins per term",
6
+ "value": 2.1168164313222078
7
+ }
interpro_domain/paths.json ADDED
@@ -0,0 +1 @@
 
 
1
+ {"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C423/C423_val_log2fc"}
interpro_domain/result.tsv ADDED
@@ -0,0 +1,178 @@
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
+ Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size
2
+ Cadherin-like [IPR002126] 0.9474744860240346 2.3895767702988007 0.0168677981596863 1.0 0.7160569658374055 4 Q08554 1
3
+ P-type ATPase, haloacid dehalogenase domain [IPR044492] 0.8320758384221487 2.293800546131534 0.0218019580495594 1.0 0.7160569658374055 7 P98194,P05023,Q9HD20 3
4
+ GOLD domain [IPR009038] 0.8212708827408625 2.2455266074947535 0.0247343460909081 1.0 0.7160569658374055 7 Q9BVK6,Q9Y3B3,P49755,Q7Z7H5,Q15363 5
5
+ Major facilitator superfamily domain [IPR020846] 0.9080459770114933 2.233137458523287 0.0255398810730449 1.0 0.7160569658374055 4 Q9H2V7,P11166,Q6NT16 3
6
+ Aminopeptidase N-like , N-terminal domain [IPR045357] 0.8499668557794031 2.1618146352445766 0.0306324669435797 1.0 0.7160569658374055 5 P55786,P09960,Q9UIQ6 3
7
+ Peptidase M1, membrane alanine aminopeptidase [IPR014782] 0.8499668557794031 2.1618146352445766 0.0306324669435797 1.0 0.7160569658374055 5 P55786,P09960,Q9UIQ6 3
8
+ Cadherin, cytoplasmic domain [IPR000233] 0.9496981128511612 2.0741088802383327 0.0380692000384226 1.0 0.7160569658374055 3 Q08554 1
9
+ Cadherin prodomain [IPR014868] 0.9496981128511612 2.0741088802383327 0.0380692000384226 1.0 0.7160569658374055 3 Q08554 1
10
+ ABC transporter type 1, transmembrane domain [IPR011527] 0.8249258160237332 2.055246042882419 0.0398552460026762 1.0 0.7160569658374055 5 O15439,P08183,O75027,P33527 4
11
+ Cation-transporting P-type ATPase, C-terminal [IPR006068] 0.8107416074713951 1.994347926109533 0.0461140451027428 1.0 0.7160569658374055 5 P98194,P05023 2
12
+ Cation-transporting P-type ATPase, N-terminal [IPR004014] 0.8107416074713951 1.994347926109533 0.0461140451027428 1.0 0.7160569658374055 5 P98194,P05023 2
13
+ Cytochrome b5-like heme/steroid binding domain [IPR001199] 0.7539157000221687 1.938613898855078 0.0525483698590898 1.0 0.7160569658374055 7 O15173,O43169,Q9UMX5 3
14
+ TRAM/LAG1/CLN8 homology domain [IPR006634] 0.8977934303614021 1.8704394979574888 0.0614228113365662 1.0 0.7160569658374055 3 Q96G23 1
15
+ Peptidase M16, N-terminal [IPR011765] 0.7371852904074738 1.860812106602266 0.0627707152266703 1.0 0.7160569658374055 7 P31930,Q10713,Q5JRX3,O43847 4
16
+ Peptidase M16, C-terminal [IPR007863] 0.7371852904074738 1.860812106602266 0.0627707152266703 1.0 0.7160569658374055 7 P31930,Q10713,Q5JRX3,O43847 4
17
+ SET domain [IPR001214] 0.7209577384955919 1.8145323972331264 0.0695957996634821 1.0 0.7160569658374055 8 Q03164,Q9H7B4 2
18
+ Intermediate filament head, DNA-binding domain [IPR006821] 0.7922505857005435 1.7585068673642898 0.0786613041233663 1.0 0.7160569658374055 4 Q16352 1
19
+ ERAP1-like C-terminal domain [IPR024571] 0.8676797627872579 1.750759644066982 0.0799873207223567 1.0 0.7160569658374055 3 P55786,Q9UIQ6 2
20
+ Dynamin-type guanine nucleotide-binding (G) domain [IPR030381] 0.7190281801989125 1.7488746671212627 0.0803126864231769 1.0 0.7160569658374055 6 O00429,Q9H223,O60313 3
21
+ Dynamin, N-terminal [IPR045063] 0.7190281801989125 1.7488746671212627 0.0803126864231769 1.0 0.7160569658374055 6 O00429,Q9H223,O60313 3
22
+ Target SNARE coiled-coil homology domain [IPR000727] 0.6931009399780828 1.653005572092325 0.0983297295468634 1.0 0.7160569658374055 7 O95721,Q12846,Q13190,O15400,Q9UNK0 5
23
+ GMP phosphodiesterase, delta subunit [IPR008015] 0.8413639733135745 1.6453844281012264 0.0998905587551477 1.0 0.7160569658374055 3 Q13432,A6NIH7 2
24
+ Phospholipid/glycerol acyltransferase [IPR002123] 0.6938361951696834 1.631364865898931 0.1028133537631674 1.0 0.7160569658374055 6 O15228,Q6UWP7,Q8NF37,Q92604 4
25
+ Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862] 0.8239436619718361 1.5752830434596905 0.1151911261571256 1.0 0.7441795158149275 3 P13674,O15460 2
26
+ Intermediate filament, rod domain [IPR039008] 0.6585772203806199 1.5130364520077235 0.1302703998831311 1.0 0.7512684201122525 8 P02545,Q16352 2
27
+ LEM domain [IPR003887] 0.6975961008759236 1.4959517825186104 0.1346662207186224 1.0 0.7512684201122525 5 P50402,Q86XL3 2
28
+ EF-hand domain [IPR002048] 0.4331323577481687 1.4843948066881691 0.1377042117100795 1.0 0.7512684201122525 35 P31949,Q9H223,Q14257,Q8NF37,Q9Y680,Q9NWM8,O75340,P07384,Q66K14,P80303,Q6NUK1,O95202,Q02818 13
29
+ Glycosyltransferase 2-like [IPR001173] 0.7953668650547671 1.45981758898874 0.144340213187547 1.0 0.7512684201122525 3 Q9Y673 1
30
+ Dynamin, GTPase domain [IPR001401] 0.7171740641483851 1.4403797427269238 0.1497599916547949 1.0 0.7608458706462081 4 O60313 1
31
+ Post-SET domain [IPR003616] 0.6693652957218215 1.3687551311008694 0.1710758306202568 1.0 0.7927911323851128 5 Q03164 1
32
+ Zinc finger, CHHC-type [IPR012996] 0.7702983239406778 1.3582090479398103 0.1743973603901158 1.0 0.7927911323851128 3 P52597 1
33
+ Reticulon [IPR003388] 0.9551685809559114 1.2956389045151515 0.1950999190889835 1.0 0.8127406265526393 2 O95197 1
34
+ Acyltransferase, C-terminal domain [IPR032098] 0.7464788732394474 1.2615770200603846 0.2071010294313549 1.0 0.8175593003058722 3 Q6UWP7,Q92604 2
35
+ MD-2-related lipid-recognition domain [IPR003172] 0.9399777695442773 1.2394627402138525 0.2151741790757735 1.0 0.8225033916994914 2 P61916 1
36
+ Syntaxin, N-terminal domain [IPR006011] 0.7342475908080082 1.2119925675534826 0.2255152257286807 1.0 0.831276155406825 3 Q12846,O15400 2
37
+ Zinc finger, RanBP2-type [IPR001876] 0.5916897442354154 1.1629299259518635 0.24485793448317 1.0 0.8401999500418841 7 Q01844,P35637 2
38
+ Desmoplakin, spectrin-like domain [IPR041573] 0.6504176322651929 1.1538343800744584 0.248568076106058 1.0 0.84504740550154 4 P15924 1
39
+ Desmoplakin, SH3 domain [IPR041615] 0.6504176322651929 1.1538343800744584 0.248568076106058 1.0 0.84504740550154 4 P15924 1
40
+ Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778] 0.7186805040770949 1.148987561924606 0.250561109491038 1.0 0.845589272034084 3 Q9BUJ2,Q1KMD3 2
41
+ Zinc finger C2H2 AKAP95-type [IPR034736] 0.7131164593320696 1.1265091883518807 0.2599500535805972 1.0 0.8468217515872207 3 Q5BKZ1 1
42
+ Acyl-CoA oxidase, C-terminal [IPR002655] 0.9047795479807345 1.1100611191208942 0.2669726901520048 1.0 0.8653469859712003 2 O15254 1
43
+ Tim10-like [IPR004217] 0.8988514264542438 1.088409555363126 0.276414344689571 1.0 0.8685164912474739 2 Q9Y5J9 1
44
+ NOPS [IPR012975] 0.6968124536693954 1.0608166831577812 0.2887732189059071 1.0 0.8719380109292185 3 Q15233,Q8WXF1 2
45
+ Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564] 0.8858836606150435 1.041230452597515 0.2977686055131969 1.0 0.8796018034854916 2 Q13505 1
46
+ Metaxin, glutathione S-transferase domain [IPR033468] 0.8858836606150435 1.041230452597515 0.2977686055131969 1.0 0.8796018034854916 2 Q13505 1
47
+ Exportin-2, central domain [IPR013713] 0.6912527798369301 1.0384886341221844 0.2990426240603598 1.0 0.8796018034854916 3 O95373,O15397 2
48
+ Domain of unknown function DUF4217 [IPR025313] 0.6911248291515435 1.0379752817120933 0.2992815630910219 1.0 0.8796018034854916 3 Q8NHQ9 1
49
+ Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547] 0.8829195998517982 1.0304855149480316 0.3027821484820605 1.0 0.8822359347209421 2 P13674 1
50
+ Ubiquitin system component CUE [IPR003892] 0.6836453332099426 1.0080097459945403 0.3134497834954413 1.0 0.8879526515532108 3 Q9UKV5 1
51
+ Peptidase M28 [IPR007484] 0.6797627872498285 0.992490631461761 0.3209582473044112 1.0 0.8940159999408928 3 Q969V3,P02786 2
52
+ Peptidase M3A/M3B catalytic domain [IPR001567] 0.6750317655606476 0.9736162480608016 0.3302471157581341 1.0 0.9061915122051276 3 Q99797 1
53
+ ABC transporter-like, ATP-binding domain [IPR003439] 0.5426829582929379 0.9580140113864424 0.3380556932959797 1.0 0.911229706150755 9 O15439,P08183,P33527,O75027 4
54
+ Amino acid transporter, transmembrane domain [IPR013057] 0.8562430529825904 0.9345533375359476 0.3500185361773948 1.0 0.9253318088762124 2 Q9H2H9 1
55
+ Band 3 cytoplasmic domain [IPR013769] 0.8291959985179752 0.8390378931507423 0.4014480458775837 1.0 0.9646491128079796 2 Q9Y6M7 1
56
+ Bicarbonate transporter, C-terminal [IPR011531] 0.8291959985179752 0.8390378931507423 0.4014480458775837 1.0 0.9646491128079796 2 Q9Y6M7 1
57
+ Class I myosin tail homology domain [IPR010926] 0.632690882134916 0.8070197921424747 0.4196550803258096 1.0 0.9748846150312298 3 O43795,O94832 2
58
+ Class I myosin, motor domain [IPR036072] 0.632690882134916 0.8070197921424747 0.4196550803258096 1.0 0.9748846150312298 3 O43795,O94832 2
59
+ Peptidase M41 [IPR000642] 0.815857725083364 0.7927425324768339 0.4279278444604686 1.0 0.9882088661107856 2 Q9Y4W6 1
60
+ Ribosomal protein S7 domain [IPR023798] 0.808818080770656 0.7685572402853136 0.4421561978738366 1.0 0.993276272214252 2 P46782 1
61
+ Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403] 0.5105143713790038 0.7587642051681532 0.4479936216348554 1.0 0.993276272214252 6 Q9BTU6 1
62
+ Sorting nexin Vps5-like, C-terminal [IPR015404] 0.5570558674835335 0.7584566429410796 0.4481776594381474 1.0 0.993276272214252 4 Q13596,Q9Y5X3 2
63
+ CYRIA/CYRIB, Rac1 binding domain [IPR009828] 0.6129078528598815 0.7311184534699737 0.4647068036880906 1.0 1.0 3 Q9NUQ9 1
64
+ Domain of unknown function DUF3517 [IPR021905] 0.7951092997406439 0.7220029211883681 0.4702926815334221 1.0 1.0 2 Q9UPU5 1
65
+ CARG-binding factor, N-terminal [IPR012956] 0.7939977769544275 0.7182616823683226 0.47259595162578 1.0 1.0 2 Q99729 1
66
+ Band 7 domain [IPR001107] 0.4963834952843139 0.7022095306950527 0.4825485028190655 1.0 1.0 7 O75955,Q99623,Q9UJZ1,Q14254 4
67
+ Threonyl/alanyl tRNA synthetase, SAD [IPR012947] 0.5423645696323545 0.6983329374632475 0.4849690053172892 1.0 1.0 4 Q5JTZ9 1
68
+ PIK-related kinase [IPR014009] 0.6021586610712935 0.6905621140319319 0.4898407630180132 1.0 1.0 3 P78527 1
69
+ FATC domain [IPR003152] 0.6021586610712935 0.6905621140319319 0.4898407630180132 1.0 1.0 3 P78527 1
70
+ PIK-related kinase, FAT [IPR003151] 0.6021586610712935 0.6905621140319319 0.4898407630180132 1.0 1.0 3 P78527 1
71
+ Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337] 0.7662097072989975 0.6265575814467703 0.5309492810630543 1.0 1.0 2 O60506 1
72
+ Small GTP-binding protein domain [IPR005225] 0.3468603112460252 0.6264393245439027 0.5310268229209214 1.0 1.0 40 P61019,Q96RP9,P61106,P51153,P40616,P51151,P62820,P36404,Q15907,Q96KC2,P51149,Q9NR31,Q969Q5,P20338,Q9NP72 15
73
+ AARP2CN [IPR012948] 0.7554649870322325 0.5921397704760933 0.5537569971444603 1.0 1.0 2 Q14692 1
74
+ Bms1/Tsr1-type G domain [IPR030387] 0.7554649870322325 0.5921397704760933 0.5537569971444603 1.0 1.0 2 Q14692 1
75
+ Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034] 0.7554649870322325 0.5921397704760933 0.5537569971444603 1.0 1.0 2 Q14692 1
76
+ Major sperm protein (MSP) domain [IPR000535] 0.5733876945885938 0.5849322658679016 0.5585932620067422 1.0 1.0 3 Q8NHP6,O95292 2
77
+ Ataxin-2, C-terminal [IPR009818] 0.4914238815848537 0.5762994068719652 0.5644128237099215 1.0 1.0 5 Q99700 1
78
+ Protein-tyrosine phosphatase, catalytic [IPR003595] 0.5693106004447839 0.570359374849336 0.5684339775631222 1.0 1.0 3 P18031,Q06124 2
79
+ Tyrosine-specific protein phosphatase, PTPase domain [IPR000242] 0.5693106004447839 0.570359374849336 0.5684339775631222 1.0 1.0 3 P18031,Q06124 2
80
+ Peptidase S9A, N-terminal domain [IPR023302] 0.7476843275287227 0.5676209264458041 0.5702923945150287 1.0 1.0 2 Q4J6C6 1
81
+ Brix domain [IPR007109] 0.5059707489981415 0.5540605854880355 0.579537383240684 1.0 1.0 4 Q9H7B2 1
82
+ Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375] 0.4937217771963848 0.507401825427833 0.6118729051526 1.0 1.0 4 Q4J6C6,Q86TI2 2
83
+ Lens epithelium-derived growth factor, integrase-binding domain [IPR021567] 0.7110040755835558 0.4572023507698434 0.6475256088555339 1.0 1.0 2 Q7Z4V5 1
84
+ Ribosomal protein L18e/L15P [IPR021131] 0.5363232023721396 0.456836568800803 0.6477885190985244 1.0 1.0 3 Q07020,P46776 2
85
+ Importin-beta, N-terminal domain [IPR001494] 0.426541207883505 0.4416718171623592 0.6587267065018458 1.0 1.0 13 O95373,Q8TEX9,Q96P70,O15397,Q9UI26,Q9HAV4 6
86
+ Legume-like lectin [IPR005052] 0.7043349388662483 0.4381425781936233 0.6612829308751156 1.0 1.0 2 P49257 1
87
+ CBS domain [IPR000644] 0.4497357380764843 0.4088887694721232 0.682621291060584 1.0 1.0 5 P54619,P51790 2
88
+ Thioredoxin domain [IPR013766] 0.3788934836291153 0.3745175532820434 0.7080192996384267 1.0 1.0 21 O95881,Q9H1E5,Q9H3N1 3
89
+ Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906] 0.68062245276029 0.3732343445169532 0.7089740367659887 1.0 1.0 2 P51812 1
90
+ Gamma tubulin complex component, C-terminal [IPR040457] 0.6780288995924418 0.3664207760379259 0.7140511191058199 1.0 1.0 2 Q96CW5 1
91
+ Gamma tubulin complex component protein, N-terminal [IPR041470] 0.6780288995924418 0.3664207760379259 0.7140511191058199 1.0 1.0 2 Q96CW5 1
92
+ Longin domain [IPR010908] 0.6743238236383862 0.3567893912469763 0.7212494788337862 1.0 1.0 2 O75396 1
93
+ v-SNARE, coiled-coil homology domain [IPR042855] 0.6743238236383862 0.3567893912469763 0.7212494788337862 1.0 1.0 2 O75396 1
94
+ TGS [IPR004095] 0.4189239332096436 0.355038642242909 0.7225606422418613 1.0 1.0 6 Q9BW92,P55039,P26639,Q9NTK5,Q9NYK5 5
95
+ Prolyl 4-hydroxylase, alpha subunit [IPR006620] 0.4185489056871387 0.3535355474837183 0.723686984055008 1.0 1.0 6 P13674,O60568,O15460 3
96
+ Oxoglutarate/iron-dependent dioxygenase [IPR005123] 0.4185489056871387 0.3535355474837183 0.723686984055008 1.0 1.0 6 P13674,O60568,O15460 3
97
+ FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179] 0.4130086002659537 0.3452922638965693 0.7298746619680059 1.0 1.0 10 Q9Y680 1
98
+ Sorting nexin, N-terminal [IPR005329] 0.6661726565394597 0.3360326433645902 0.7368462504694644 1.0 1.0 2 Q13596 1
99
+ OCRE domain [IPR041591] 0.4918458117123843 0.3190287905393781 0.7497046809214809 1.0 1.0 3 P78332,P98175 2
100
+ CRAL-TRIO lipid binding domain [IPR001251] 0.6587625046313472 0.3176921727207302 0.7507184491318499 1.0 1.0 2 P21359 1
101
+ Ras GTPase-activating domain [IPR001936] 0.4330737856878043 0.2964394241874348 0.7668945213934919 1.0 1.0 4 P46940,Q14C86,P21359 3
102
+ TRASH domain [IPR011017] 0.4315906562847638 0.2917898456993626 0.7704473095201458 1.0 1.0 4 Q14202,P83731,Q5VZL5 3
103
+ Far upstream element-binding protein, C-terminal [IPR015096] 0.6454242311967398 0.2859957540902143 0.7748813735450699 1.0 1.0 2 Q92945 1
104
+ Tim44-like domain [IPR007379] 0.6435716932197126 0.2817307902405594 0.7781499432062429 1.0 1.0 2 O43615 1
105
+ GYF domain [IPR003169] 0.6365320489070045 0.2658364107728125 0.7903652000853765 1.0 1.0 2 O95400 1
106
+ G-protein gamma-like domain [IPR015898] 0.6350500185253819 0.2625538897417256 0.7928944440382759 1.0 1.0 2 Q9UBI6 1
107
+ OBG-type guanine nucleotide-binding (G) domain [IPR031167] 0.4186132740081603 0.2523320386523776 0.8007844258922667 1.0 1.0 4 Q9NTK5,Q9BZE4,P55039 3
108
+ Pleckstrin homology domain, spectrin-type [IPR001605] 0.6276398666172672 0.2464781209208239 0.8053121390765923 1.0 1.0 2 O15020 1
109
+ Pleckstrin homology domain 9 [IPR041681] 0.6276398666172672 0.2464781209208239 0.8053121390765923 1.0 1.0 2 O15020 1
110
+ MCM domain [IPR001208] 0.3870129870129821 0.2337374309673706 0.815188826819599 1.0 1.0 6 P33993,P33992,P25205,Q14566,P49736 5
111
+ MCM OB domain [IPR033762] 0.3870129870129821 0.2337374309673706 0.815188826819599 1.0 1.0 6 P33993,P33992,P25205,Q14566,P49736 5
112
+ MCM, AAA-lid domain [IPR041562] 0.3870129870129821 0.2337374309673706 0.815188826819599 1.0 1.0 6 P33993,P33992,P25205,Q14566,P49736 5
113
+ MCM N-terminal domain [IPR027925] 0.3870129870129821 0.2337374309673706 0.815188826819599 1.0 1.0 6 P33993,P33992,P25205,Q14566,P49736 5
114
+ Protein kinase, C-terminal [IPR017892] 0.4091815075691852 0.2250991871237935 0.8219021133362645 1.0 1.0 4 P51812,P31749 2
115
+ Alpha-L-fucosidase, C-terminal [IPR031919] 0.6168951463505032 0.2241807998096752 0.8226166228146905 1.0 1.0 2 Q9BTY2 1
116
+ Plasma membrane calcium transporting P-type ATPase, C-terminal [IPR022141] 0.6165246387550976 0.2234335823995517 0.8231980699070129 1.0 1.0 2 P23634 1
117
+ F-box domain [IPR001810] 0.6105965172286059 0.2116764838970271 0.8323594355042312 1.0 1.0 2 Q13309 1
118
+ SH3 domain [IPR001452] 0.2811483016818684 0.1802362829051468 0.8569670751861604 1.0 1.0 31 Q9UQB8,P15924,Q9Y5X1 3
119
+ B-box-type zinc finger [IPR000315] 0.3812865422304317 0.1522695867787927 0.878974311409795 1.0 1.0 4 P19474 1
120
+ Glutamine amidotransferase type 2 domain [IPR017932] 0.4062034084391764 0.1205997795196676 0.9040080434866402 1.0 1.0 3 P08243 1
121
+ VHS domain [IPR002014] 0.5468692108188246 0.1093153478837163 0.91295237369645 1.0 1.0 2 Q92783 1
122
+ PWWP domain [IPR000313] 0.3502928792519137 0.1092764177546203 0.9129832504728964 1.0 1.0 7 O96028 1
123
+ Beta-adaptin appendage, C-terminal subdomain [IPR015151] 0.3984432913269065 0.1076405659695839 0.9142808169286724 1.0 1.0 3 Q10567,O00203 2
124
+ HDGF-related, PWWP domain [IPR035496] 0.3959411711233624 0.103645132511438 0.917450969946492 1.0 1.0 3 Q7Z4V5 1
125
+ UBX domain [IPR001012] 0.3583909155374106 0.1017293224030675 0.918971526967576 1.0 1.0 4 Q9UNZ2 1
126
+ Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain [IPR008152] 0.3523738872403554 0.0986275300293457 0.9214340107825352 1.0 1.0 5 P63010,Q10567,O94973,O43747 4
127
+ Hexokinase, N-terminal [IPR022672] 0.5313078918117888 0.0909303924963587 0.927547900502354 1.0 1.0 2 P52789 1
128
+ Hexokinase, C-terminal [IPR022673] 0.5313078918117888 0.0909303924963587 0.927547900502354 1.0 1.0 2 P52789 1
129
+ Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019] 0.5198221563542116 0.0789375174403648 0.9370823217305028 1.0 1.0 2 P07686 1
130
+ Glycoside hydrolase family 20, catalytic domain [IPR015883] 0.5198221563542116 0.0789375174403648 0.9370823217305028 1.0 1.0 2 P07686 1
131
+ NAD-dependent epimerase/dehydratase [IPR001509] 0.3787991104521856 0.0786463016174386 0.9373139582028378 1.0 1.0 3 Q9NRG7,Q16795 2
132
+ Synaptotagmin, SMP domain [IPR039010] 0.5168580955909602 0.0760530285716065 0.9393769096229164 1.0 1.0 2 Q9BSJ8 1
133
+ Extended synaptotagmin, C2B domain [IPR037749] 0.5168580955909602 0.0760530285716065 0.9393769096229164 1.0 1.0 2 Q9BSJ8 1
134
+ Extended synaptotagmin, C-terminal C2 domain [IPR037752] 0.5168580955909602 0.0760530285716065 0.9393769096229164 1.0 1.0 2 Q9BSJ8 1
135
+ Extended synaptotagmin, C2A domain [IPR037733] 0.5168580955909602 0.0760530285716065 0.9393769096229164 1.0 1.0 2 Q9BSJ8 1
136
+ Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468] 0.5168580955909602 0.0760530285716065 0.9393769096229164 1.0 1.0 2 Q9BSJ8 1
137
+ Stromalin conservative domain [IPR020839] 0.5146350500185243 0.0739451370471446 0.9410540399637202 1.0 1.0 2 Q8WVM7 1
138
+ STAG [IPR013721] 0.5146350500185243 0.0739451370471446 0.9410540399637202 1.0 1.0 2 Q8WVM7 1
139
+ B-box, C-terminal [IPR003649] 0.3732394366197168 0.0714139731241332 0.943068289059015 1.0 1.0 3 O15344,Q9UPN9 2
140
+ WWE domain [IPR004170] 0.3702742772424127 0.0677282924016117 0.9460019269367032 1.0 1.0 3 Q14669,Q7Z6Z7 2
141
+ Translation initiation factor IF2/IF5 domain [IPR002735] 0.5068543905150134 0.0669352365906194 0.9466332611865156 1.0 1.0 2 P55010 1
142
+ Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004] 0.3628613787991189 0.0590271727566345 0.9529304651102344 1.0 1.0 3 O95071,Q13310 2
143
+ EF hand associated, type-1 [IPR013566] 0.4894405335309403 0.0532318061102025 0.957547213921126 1.0 1.0 2 Q8IXI1 1
144
+ MIRO domain [IPR020860] 0.4894405335309403 0.0532318061102025 0.957547213921126 1.0 1.0 2 Q8IXI1 1
145
+ EF hand associated, type-2 [IPR013567] 0.4894405335309403 0.0532318061102025 0.957547213921126 1.0 1.0 2 Q8IXI1 1
146
+ 26S proteasome regulatory subunit Rpn7, N-terminal [IPR045135] 0.4686921081882275 0.0401945222544934 0.9679380447104508 1.0 1.0 2 Q13098 1
147
+ B30.2/SPRY domain [IPR001870] 0.3282859908584157 0.0376875362708352 0.9699368135529768 1.0 1.0 9 Q9UBL3,Q9BUJ2,P19474,Q1KMD3 4
148
+ SPRY domain [IPR003877] 0.3282859908584157 0.0376875362708352 0.9699368135529768 1.0 1.0 9 Q9UBL3,Q9BUJ2,P19474,Q1KMD3 4
149
+ DNA mismatch repair protein MutS, clamp [IPR007861] 0.4531307891811885 0.0324964680688684 0.9740761326164696 1.0 1.0 2 P43246 1
150
+ RING-type zinc-finger, LisH dimerisation motif [IPR027370] 0.451648758799554 0.0318474256860093 0.9745937255714592 1.0 1.0 2 Q9UPN9 1
151
+ Nucleoporin, Nup133/Nup155-like, C-terminal [IPR007187] 0.4468321600592809 0.0298327659886225 0.9762004269099034 1.0 1.0 2 O75694 1
152
+ RasGAP protein, C-terminal [IPR000593] 0.4327528714338636 0.0247229176289212 0.9802759750415022 1.0 1.0 2 P46940 1
153
+ NUC153 [IPR012580] 0.4323823638384624 0.0246031508935096 0.980371506012024 1.0 1.0 2 Q9BSC4 1
154
+ Phosphoinositide 3-kinase, accessory (PIK) domain [IPR001263] 0.4238606891441271 0.0220403136243571 0.9824157977176192 1.0 1.0 2 P42356 1
155
+ Arginyl-tRNA synthetase, catalytic core domain [IPR035684] 0.4234901815487186 0.0219369428938874 0.9824982556908476 1.0 1.0 2 Q5T160 1
156
+ DALR anticodon binding [IPR008909] 0.4234901815487186 0.0219369428938874 0.9824982556908476 1.0 1.0 2 Q5T160 1
157
+ Mu homology domain [IPR028565] 0.3059271911143246 0.0185959727624687 0.9851634155516902 1.0 1.0 4 Q96CW1,Q9BXS5 2
158
+ Sec63 domain [IPR004179] 0.3143068939955482 0.0185436393910636 0.9852051643418454 1.0 1.0 3 O75643,Q9UGP8 2
159
+ Dynein heavy chain region D6 P-loop domain [IPR004273] 0.4071878473508701 0.0179913689062257 0.98564573891311 1.0 1.0 2 Q14204 1
160
+ Dynein heavy chain AAA lid domain [IPR041658] 0.4071878473508701 0.0179913689062257 0.98564573891311 1.0 1.0 2 Q14204 1
161
+ Dynein heavy chain, tail [IPR013594] 0.4071878473508701 0.0179913689062257 0.98564573891311 1.0 1.0 2 Q14204 1
162
+ Dynein heavy chain, linker [IPR013602] 0.4071878473508701 0.0179913689062257 0.98564573891311 1.0 1.0 2 Q14204 1
163
+ Dynein heavy chain, ATP-binding dynein motor region [IPR035706] 0.4071878473508701 0.0179913689062257 0.98564573891311 1.0 1.0 2 Q14204 1
164
+ Dynein heavy chain, C-terminal domain [IPR041228] 0.4071878473508701 0.0179913689062257 0.98564573891311 1.0 1.0 2 Q14204 1
165
+ Dynein heavy chain, coiled coil stalk [IPR024743] 0.4071878473508701 0.0179913689062257 0.98564573891311 1.0 1.0 2 Q14204 1
166
+ Dynein heavy chain, hydrolytic ATP-binding dynein motor region [IPR035699] 0.4071878473508701 0.0179913689062257 0.98564573891311 1.0 1.0 2 Q14204 1
167
+ Dynein heavy chain, AAA module D4 [IPR024317] 0.4071878473508701 0.0179913689062257 0.98564573891311 1.0 1.0 2 Q14204 1
168
+ Ribosome receptor lysine/proline rich [IPR007794] 0.3679140422378635 0.0123052612028744 0.9901820698411414 1.0 1.0 2 Q86UP2 1
169
+ IPT domain [IPR002909] 0.3642089662838063 0.011975988959044 0.990444771718452 1.0 1.0 2 Q96KP1 1
170
+ Ku70/Ku80 C-terminal arm [IPR005160] 0.361985920711371 0.0117916067204081 0.9905918770719198 1.0 1.0 2 P12956 1
171
+ Ku70/Ku80, N-terminal alpha/beta [IPR005161] 0.361985920711371 0.0117916067204081 0.9905918770719198 1.0 1.0 2 P12956 1
172
+ Ku70/Ku80 beta-barrel domain [IPR006164] 0.361985920711371 0.0117916067204081 0.9905918770719198 1.0 1.0 2 P12956 1
173
+ Nucleotidyl transferase domain [IPR005835] 0.3534642460170424 0.0111687369140967 0.9910888225173544 1.0 1.0 2 Q9NR50 1
174
+ Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain [IPR003164] 0.3519822156354159 0.0110730007015497 0.9911652042398742 1.0 1.0 2 O94973 1
175
+ Helicase/UvrB, N-terminal [IPR006935] 0.3297517599110784 0.0100003625647847 0.9920209981003572 1.0 1.0 2 P19447 1
176
+ Heat shock chaperonin-binding [IPR006636] 0.2961452928094864 0.0096261208322626 0.9923195854217196 1.0 1.0 3 P54727,Q9NRR5 2
177
+ UAS [IPR006577] 0.3001111522786145 0.0093031415332732 0.9925772740746864 1.0 1.0 2 Q96CS3 1
178
+ Ubiquitin conjugation factor E4, core [IPR019474] 0.2823267876991396 0.0091119741648956 0.9927297971006908 1.0 1.0 2 Q14139 1
interpro_domain/selections.json ADDED
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interpro_family/advanced/idx2term.json ADDED
@@ -0,0 +1 @@
 
 
1
+ {"0": "Transmembrane emp24 domain-containing protein [IPR015720]"}
interpro_family/advanced/plot_0.png ADDED

Git LFS Details

  • SHA256: 2ac18b7a93b539fede4216c6d1bb70deb8210d99d19f634d1eda3c04bd25b8dd
  • Pointer size: 131 Bytes
  • Size of remote file: 179 kB
interpro_family/basic/idx2term.json ADDED
@@ -0,0 +1 @@
 
 
1
+ {"0": "Transmembrane emp24 domain-containing protein [IPR015720]", "1": "Mitochondrial carrier protein [IPR002067]", "2": "Proteasome, subunit alpha/beta [IPR001353]", "3": "Small GTPase [IPR001806]", "4": "Mini-chromosome maintenance protein [IPR031327]"}
interpro_family/basic/plot_0.png ADDED

Git LFS Details

  • SHA256: 8d8d9dac56d4ca7c2a734757c9978800b22da3fb2a2fe5b437ad055a2aa31f75
  • Pointer size: 131 Bytes
  • Size of remote file: 141 kB
interpro_family/basic/plot_1.png ADDED

Git LFS Details

  • SHA256: 16ccee713c510cd4fb522e4b7f139e452697909f56bbd65a5754ba73024f2a5a
  • Pointer size: 131 Bytes
  • Size of remote file: 132 kB