diff --git a/interpro_active_site/advanced/idx2term.json b/interpro_active_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_active_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_active_site/basic/idx2term.json b/interpro_active_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_active_site/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_active_site/consensus.joblib b/interpro_active_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..cc51c36ec53faf7fa97fef9cbaee2a7bbd84e964 --- /dev/null +++ b/interpro_active_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:9ea14ea98e11fdd8a6faeb8c2905d122f7e33c46ccc44296575112d721947fc4 +size 68132 diff --git a/interpro_active_site/df_merge.tsv b/interpro_active_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_active_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_active_site/metrics.json b/interpro_active_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..5dae34e35dda32a96b3004a6b088e5ecf7b025f5 --- /dev/null +++ b/interpro_active_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2812, + "annotations_size": 55, + "title": "Average number of proteins per term", + "value": 2.3454545454545452 +} \ No newline at end of file diff --git a/interpro_active_site/paths.json b/interpro_active_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..2f436697ef35c3b4c1ce088f3930462150b2c58e --- /dev/null +++ b/interpro_active_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C428/C428_val_log2fc"} \ No newline at end of file diff --git a/interpro_active_site/result.tsv b/interpro_active_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..2e31c1e5410c8277c2499cd771659a029df53a66 --- /dev/null +++ b/interpro_active_site/result.tsv @@ -0,0 +1,6 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Histidine acid phosphatase active site [IPR033379] 0.8928825622775785 1.5159951898078918 0.1295205687158602 0.9995139082554834 0.2968179699738464 2 P11117 1 +Protein-tyrosine phosphatase, active site [IPR016130] 0.7264643457319988 1.379102104557932 0.1678632750731459 0.999959195514136 0.3419437084823342 5 Q9Y217,Q06124 2 +Serine carboxypeptidase, serine active site [IPR018202] 0.907636865836474 1.335365276180793 0.1817568237829161 0.9999838366428432 0.3515804655167711 3 Q9HB40 1 +Peptidase S9, serine active site [IPR002471] 0.6658362989323828 0.615995171564202 0.5378977065544421 1.0 0.7396093465123579 2 P48147 1 +ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440] 0.4330960854092507 0.0707980076245964 0.9435585175327748 1.0 0.9757082046299924 2 P53597 1 diff --git a/interpro_active_site/selections.json b/interpro_active_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..3b0058e23c781d155c7fe892ff864dcdc652f2f7 --- /dev/null +++ b/interpro_active_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenosine/AMP deaminase active site [IPR006650]", "Adenylosuccinate synthase, active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Coenzyme A transferase active site [IPR004164]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glutaredoxin active site [IPR011767]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine proteases, trypsin family, histidine active site [IPR018114]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]", "Uracil-DNA glycosylase, active site [IPR018085]"], "available_proteins": ["ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADSS", "AKT2", "AMPD2", "APEH", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "BLMH", "CAMK2G", "CAPN1", "CAPN2", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CHEK2", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "CTSB", "CTSC", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLRX", "GLUD1", "GSR", "GUSB", "HADHB", "HMGCS1", "IGF1R", "LDHA", "LDHB", "LONP1", "MAP2K1", "MAP2K4", "MAPK1", "MDH1", "MDH2", "MTMR6", "NEK9", "NME1", "OXCT1", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKN2", "PLK1", "PREP", "PRKAA1", "PRKACA", "PRKCB", "PRPF4B", "PRSS3", "PTK7", "PTPN1", "PTPN11", "PTPRF", "RIPK1", "RNASET2", "ROCK1", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SUCLG1", "TALDO1", "TAOK1", "TIGAR", "TOP1", "TPI1", "TPP2", "TXNRD1", "TXNRD2", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2S", "UMPS", "UNG", "VRK1", "WNK1"], "leading_proteins": ["ACP2", "MTMR6", "PREP", "PTPN11", "SCPEP1", "SUCLG1"]} \ No newline at end of file diff --git a/interpro_binding_site/advanced/idx2term.json b/interpro_binding_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_binding_site/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_binding_site/basic/idx2term.json b/interpro_binding_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..1f2df466d020a9613ebb803cec2bf89e8e4d80ca --- /dev/null +++ b/interpro_binding_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "EF-Hand 1, calcium-binding site [IPR018247]"} \ No newline at end of file diff --git a/interpro_binding_site/basic/plot_0.png b/interpro_binding_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..c601832bb464718ab35ad3a61f1bf18e0a01bd1f --- /dev/null +++ b/interpro_binding_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:eb2c038149e48adbe32429b85cc391abd1b8bfe1ffcaaae3e888a495437ec5ee +size 147607 diff --git a/interpro_binding_site/consensus.joblib b/interpro_binding_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..1dde7907b4471bc9250c6a8a41301880852f61b3 --- /dev/null +++ b/interpro_binding_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:1e77922de6d9c59b1775826248b7a7b73d77f41a858e5e802fe89835de5f89fb +size 65516 diff --git a/interpro_binding_site/df_merge.tsv b/interpro_binding_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_binding_site/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_binding_site/metrics.json b/interpro_binding_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..9aed39511efe3787171c1f245f51ba9acae7fead --- /dev/null +++ b/interpro_binding_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2812, + "annotations_size": 31, + "title": "Average number of proteins per term", + "value": 3.806451612903226 +} \ No newline at end of file diff --git a/interpro_binding_site/paths.json b/interpro_binding_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..1fe3bb62a3e0090e01e540a85dcef14d73c7ec62 --- /dev/null +++ b/interpro_binding_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C428/C428_val_log2fc"} \ No newline at end of file diff --git a/interpro_binding_site/result.tsv b/interpro_binding_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..505a87b42e2a13b63c8a512253a2c8c08b4e6490 --- /dev/null +++ b/interpro_binding_site/result.tsv @@ -0,0 +1,3 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Beta tubulin, autoregulation binding site [IPR013838] 0.8063443746058448 1.3035067198458916 0.1924018237166755 0.9986724367670954 0.3599957918437211 4 Q9BVA1,P07437 2 +EF-Hand 1, calcium-binding site [IPR018247] 0.2763703116266652 0.1461982747724726 0.8837648674602605 1.0 0.9447141686644164 32 Q14257,O43852,Q96D71,P80303,Q9H223 5 diff --git a/interpro_binding_site/selections.json b/interpro_binding_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..3f68994984e426e747a1233c461236a13424f7b0 --- /dev/null +++ b/interpro_binding_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Coenzyme A transferase binding site [IPR004163]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]", "Ureohydrolase, manganese-binding site [IPR020855]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT2", "APEX1", "APOBEC3C", "ARG2", "BPNT1", "CALU", "CAMK2G", "CAPN1", "CAPN2", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DLAT", "DLST", "EHD1", "EHD4", "EIF2AK2", "EPS15", "EPS15L1", "FKBP10", "GCAT", "GOT1", "GOT2", "GPD2", "HK1", "HK2", "HMBS", "IDE", "IGF1R", "ILKAP", "IQGAP1", "IQGAP2", "IQSEC1", "LETM1", "MACF1", "MAP2K1", "MAP2K4", "MAPK1", "MAPK14", "MCCC1", "MICU1", "MYH10", "MYH9", "MYO1B", "MYO1C", "MYO1D", "NRDC", "NUCB1", "NUCB2", "OXCT1", "PA2G4", "PAK2", "PC", "PCCA", "PDCD6", "PEF1", "PGD", "PKN2", "PLCG1", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PPM1F", "PPM1G", "PRKAA1", "PRKACA", "PRKCB", "PRKCSH", "PSAT1", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK1", "RPS6KA1", "RPS6KA3", "S100A11", "SDHA", "SDHB", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "TAOK1", "TBK1", "TKT", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["CALU", "EHD4", "NUCB2", "RCN2", "REPS1", "TUBB", "TUBB2B"]} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/idx2term.json b/interpro_conserved_site/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..c30ae90f25e9e45b4aea6635eac1aaa141ffd89e --- /dev/null +++ b/interpro_conserved_site/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Proteasome beta-type subunit, conserved site [IPR016050]", "1": "Zinc finger, RING-type, conserved site [IPR017907]"} \ No newline at end of file diff --git a/interpro_conserved_site/advanced/plot_0.png b/interpro_conserved_site/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..130a1102a553bc2ef066c6764c9e4ab13b8e0c33 --- /dev/null +++ b/interpro_conserved_site/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:e81180d298ae0dd1e962fe7666c0aac59d148f326c460a424c86de6173efd7a9 +size 192842 diff --git a/interpro_conserved_site/advanced/plot_1.png b/interpro_conserved_site/advanced/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..54d7cf197c12f0bd1b3ce97ddc5c56398f4518b5 --- /dev/null +++ b/interpro_conserved_site/advanced/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:4bfee9d8fbdc761575444a8ad03f93fb61700971f2cbd6773a253ea50dfeeaff +size 196427 diff --git a/interpro_conserved_site/basic/idx2term.json b/interpro_conserved_site/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..911eda7486e8b79fa008f3d7e66f6971a5387fa2 --- /dev/null +++ b/interpro_conserved_site/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Proteasome beta-type subunit, conserved site [IPR016050]", "1": "Zinc finger, RING-type, conserved site [IPR017907]", "2": "14-3-3 protein, conserved site [IPR023409]"} \ No newline at end of file diff --git a/interpro_conserved_site/basic/plot_0.png b/interpro_conserved_site/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..78d33d129f0e75c5d7b808141f731d344122e66f --- /dev/null +++ b/interpro_conserved_site/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:b39aa5e3796bd4c09556dbeb1c025152fe5da6335b6294a89bb5712d842ee2f1 +size 146635 diff --git a/interpro_conserved_site/basic/plot_1.png b/interpro_conserved_site/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..f69205bd3495b899d4531bcccf3936d3c81d5ec7 --- /dev/null +++ b/interpro_conserved_site/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:44b300244e7ce789b6a97abb9a7f6b2238c843d18e37f2eacbf0392dce947111 +size 140974 diff --git a/interpro_conserved_site/basic/plot_2.png b/interpro_conserved_site/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..d96eb02ae7e1ea84b99cb2a4ae22245eca5ade31 --- /dev/null +++ b/interpro_conserved_site/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:836192ca3c74a9c8264f691c6081abf731ac60ec16be380ae4ea58f7038c6a79 +size 142057 diff --git a/interpro_conserved_site/consensus.joblib b/interpro_conserved_site/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..ab62de9525eafc0627c43e9c91376f0765aaac18 --- /dev/null +++ b/interpro_conserved_site/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:224d58dabdfefd28dde5ebf817ffaf891b605c290e5150729130a0df2052b159 +size 87044 diff --git a/interpro_conserved_site/df_merge.tsv b/interpro_conserved_site/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..de5ca70adb3afdb3da3f26d43316ef6115e72ae7 --- /dev/null +++ b/interpro_conserved_site/df_merge.tsv @@ -0,0 +1,3 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Proteasome beta-type subunit, conserved site [IPR016050] 6 8 2.6144405821107077 0.0089373704314283 3.7135922330097086 7.970873786407767 1.4913184573846054 0.1902243906475925 1.515457478026574 0.1681602725795027 1.0170822776023185 0.2455850375425174 3.5930470170495774e-05 0.0010343090391069 9.839858993160587e-05 3.59582749836129e-08 6.442496475603332e-08 +Zinc finger, RING-type, conserved site [IPR017907] 7 14 1.965327334116363 0.0493763638823894 4.609223300970874 14.776699029126211 -0.045326225777209 0.5577732895844865 3.238903742779499 4.550007017672923 0.8841385018499901 0.2924846286854669 1.0 1.0 1.0 0.9161766745136084 0.8745957259037637 diff --git a/interpro_conserved_site/metrics.json b/interpro_conserved_site/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..6b08053b963166071cb83a340acfb114c6c3b277 --- /dev/null +++ b/interpro_conserved_site/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2812, + "annotations_size": 259, + "title": "Average number of proteins per term", + "value": 2.6563706563706564 +} \ No newline at end of file diff --git a/interpro_conserved_site/paths.json b/interpro_conserved_site/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..bf6dc753fc8c53b25661e21c59592ee082ca00c5 --- /dev/null +++ b/interpro_conserved_site/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C428/C428_val_log2fc"} \ No newline at end of file diff --git a/interpro_conserved_site/result.tsv b/interpro_conserved_site/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..b2a8c160664ece7ebb75162b0b24316fc10705aa --- /dev/null +++ b/interpro_conserved_site/result.tsv @@ -0,0 +1,29 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Proteasome beta-type subunit, conserved site [IPR016050] 0.8873246927674877 2.6144405821107073 0.0089373704314283 0.9022346450425428 0.0845387370726674 8 P28074,P20618,Q99436,P28072,P28070,P49721 6 +Zinc finger, RING-type, conserved site [IPR017907] 0.6248655100810386 1.965327334116363 0.0493763638823894 0.9999979852110934 0.2131413040923143 14 O15344,Q5VTR2,Q9H000,Q99496,P19474,Q14258,Q9UBS8 7 +Haem oxygenase conserved site [IPR018207] 0.972241992882564 1.841192043332856 0.0655934209443853 0.999999976622671 0.2654483753843095 2 P30519 1 +Glycoside hydrolase, family 35, conserved site [IPR019801] 0.9434163701067636 1.7234980663625985 0.0847984945480808 0.999999999892147 0.3179255134861725 2 Q8IW92 1 +Guanylate kinase, conserved site [IPR020590] 0.8615887284167849 1.515047308890242 0.1297604238773468 0.9999999999999998 0.3819085202753732 4 Q14168,O14936 2 +Immunoglobulin/major histocompatibility complex, conserved site [IPR003006] 0.9401922392310432 1.454826982285097 0.1457171663124929 1.0 0.3964138717367543 3 P55899,P04439 2 +Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818] 0.8390366092740751 1.4288214842023483 0.1530555489331098 1.0 0.3964138717367543 4 P48735 1 +Glycoside hydrolase, family 29, conserved site [IPR018526] 0.8594306049822151 1.378332726868318 0.1681005832940041 1.0 0.4234385222086269 2 Q9BTY2 1 +Thioredoxin, conserved site [IPR017937] 0.5797640670401556 1.3652473246497838 0.1721753287319991 1.0 0.4234385222086269 10 O95881 1 +Profilin conserved site [IPR027310] 0.8558718861209968 1.3636977697953243 0.1726627062654804 1.0 0.4234385222086269 2 P35080 1 +Tubulin, conserved site [IPR017975] 0.8063443746058448 1.3035067198458916 0.1924018237166755 1.0 0.4429462349575486 4 Q9BVA1,P07437 2 +Ubiquitin interacting motif [IPR003903] 0.898685211187423 1.3025301025720954 0.1927352344036359 1.0 0.4429462349575486 3 Q92783 1 +DnaJ domain, conserved site [IPR018253] 0.5785541390239369 1.2627219309347624 0.2066891296360524 1.0 0.4589911306384225 9 Q99543,O60884 2 +Phosphatidylinositol 3/4-kinase, conserved site [IPR018936] 0.6969913132754599 0.8874763096982349 0.3748225152468571 1.0 0.655939401682 4 P42356,P42345 2 +Ubiquitin specific protease, conserved site [IPR018200] 0.432751396353463 0.8223687509824515 0.4108670587290803 1.0 0.6777997975212218 14 Q96K76,Q9UPU5,Q8TEY7,Q96RU2 4 +Sugar transporter, conserved site [IPR005829] 0.6885582362252703 0.565748582689084 0.57156470399169 1.0 0.7774724948205761 3 Q5SR56 1 +Annexin repeat, conserved site [IPR018252] 0.4481152811367704 0.5219084417124175 0.601734080403064 1.0 0.7871168021434019 7 P50995,P04083 2 +14-3-3 protein, conserved site [IPR023409] 0.4354953670705573 0.3889432256894514 0.6973181452731891 1.0 0.8282584517582144 6 P31946,P61981,P62258,P63104,Q04917 5 +Phosphorylase pyridoxal-phosphate attachment site [IPR035090] 0.5914590747330902 0.3736200512772922 0.7086870138387349 1.0 0.8329389358276973 2 P06737 1 +Heat shock protein Hsp90, conserved site [IPR019805] 0.573474852456086 0.2499077058366811 0.8026587238781326 1.0 0.889356803448252 3 P14625 1 +Fumarate lyase, conserved site [IPR020557] 0.4765124555160116 0.1212182236464325 0.9035181901715184 1.0 0.9710008765743704 2 P07954 1 +DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514] 0.4608540925266834 0.1003337346565336 0.920079376227837 1.0 0.9742297109840388 2 P19387 1 +ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847] 0.4330960854092507 0.0707980076245964 0.9435585175327748 1.0 0.9831336931348345 2 P53597 1 +Zinc finger, PHD-type, conserved site [IPR019786] 0.2781690072860034 0.0520406584197719 0.9584962965545178 1.0 0.9890459793132276 15 O96028 1 +HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637] 0.3807829181494704 0.0371839121405647 0.9703383659936112 1.0 0.9921212944871114 2 P52926 1 +Intermediate filament protein, conserved site [IPR018039] 0.3250450491084149 0.0263915572335404 0.978945028157653 1.0 0.9943010285993416 5 P08670 1 +Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867] 0.290391459074739 0.019850284973368 0.984162804164154 1.0 0.994693267133942 2 P13995 1 +AT hook, DNA-binding motif [IPR017956] 0.3741545033819922 0.0114646256399731 0.9908527525890234 1.0 0.994693267133942 3 P52926,P17096 2 diff --git a/interpro_conserved_site/selections.json b/interpro_conserved_site/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..afc796bacbc3243723db77e001267adb63539a8f --- /dev/null +++ b/interpro_conserved_site/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Aldose 1-epimerase, conserved site [IPR018052]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Amyloidogenic glycoprotein, copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "CBX family C-terminal motif [IPR033773]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific, conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Fibrillarin, conserved site [IPR020813]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glutathione peroxidase conserved site [IPR029760]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site [IPR023076]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NADH:ubiquinone oxidoreductase, subunit 1, conserved site [IPR018086]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P, conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class II, conserved site [IPR002011]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]"], "available_proteins": ["AAAS", "AACS", "AAMP", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA2", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK3", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "AP3S1", "APEX1", "APLP2", "ARHGEF7", "ARIH2", "ATAD1", "ATAD2", "ATP5C1", "ATP5O", "BAG6", "BAZ1A", "BAZ1B", "BCS1L", "BDH2", "BOP1", "BPNT1", "BPTF", "BRD1", "BRD2", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDH2", "CDKAL1", "CHAF1B", "CHD1", "CHD1L", "CHD4", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "CORO1C", "CPOX", "CRYZ", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYP51A1", "DCAF13", "DCAF7", "DCPS", "DCXR", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX35", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DRG1", "DRG2", "DSG2", "DTYMK", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPRS", "EPS15", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FARP2", "FBL", "FCGRT", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FUCA1", "FUCA2", "GAA", "GALK1", "GALM", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLB1L2", "GLO1", "GMPPA", "GNPDA1", "GNS", "GPHN", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "GTF3C2", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGA2", "HMGB1", "HMGB2", "HMGB3", "HMGCR", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IGF1R", "ILVBL", "IMPAD1", "IMPDH2", "IQGAP1", "IQGAP2", "IVD", "KDM2A", "KDM5A", "KDSR", "KIF11", "KIF14", "KIF18A", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "LAMP1", "LARS", "LARS2", "LBR", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRP1", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK14", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME2", "MFSD14B", "MID1", "MIF", "MKRN2", "MPHOSPH8", "MPI", "MPP2", "MPP6", "MPP7", "MPST", "MRPL13", "MRPL24", "MRPL3", "MRPS11", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "ND1", "NDUFS1", "NDUFS2", "NDUFS3", "NEFM", "NF1", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD2", "NSF", "NUDT1", "NUDT12", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF3", "PHGDH", "PHIP", "PI4KA", "PIK3C2A", "PLEC", "PLOD1", "PLOD2", "PLRG1", "PLS1", "PLS3", "PNP", "POLA1", "POLD1", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR2E", "POLR3B", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "RACK1", "RAE1", "RANBP2", "RARS", "RCL1", "RDH13", "RDX", "RIDA", "RNF14", "RNF2", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSF1", "RSL24D1", "RTN4IP1", "S100A11", "SART1", "SBDS", "SCAF11", "SCD", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A4", "SLC2A1", "SLIT2", "SMARCA4", "SMU1", "SNRNP40", "SNU13", "SORD", "SPTBN1", "SRCAP", "SRM", "STAM", "STMN1", "STX12", "STX18", "STX4", "STX5", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SV2A", "SYNE2", "TAF5", "TBL3", "TCP1", "TFB1M", "THOC6", "TK1", "TLN1", "TMX1", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TRMT11", "TSFM", "TSPAN6", "TST", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UBFD1", "UHRF1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP33", "USP36", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VAT1", "VCL", "VCP", "VIM", "VPS4A", "VPS4B", "WARS", "WARS2", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR36", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZMYND8"], "leading_proteins": ["ANXA1", "ANXA11", "CASK", "DNAJA2", "DNAJC2", "FCGRT", "FH", "FUCA2", "GLB1L2", "HLA-A", "HMGA1", "HMGA2", "HMOX2", "HSP90B1", "IDH2", "MFSD14B", "MID1", "MKRN2", "MPP2", "MTHFD2", "MTOR", "NSD2", "PFN2", "PI4KA", "POLR2C", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PYGL", "RNF14", "RNF2", "RNF20", "STAM", "SUCLG1", "TRIM21", "TRIM25", "TUBB", "TUBB2B", "TXNDC12", "USP24", "USP28", "USP33", "USP47", "VIM", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAZ"]} \ No newline at end of file diff --git a/interpro_domain/advanced/idx2term.json b/interpro_domain/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..d5f84ba4b4e8e6bdbed722d4c8fb01f997215c85 --- /dev/null +++ b/interpro_domain/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "K Homology domain [IPR004087]", "1": "K Homology domain, type 1 [IPR004088]"} \ No newline at end of file diff --git a/interpro_domain/advanced/plot_0.png b/interpro_domain/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..a27144b7cb70987067bace178d344a9669ea465f --- /dev/null +++ b/interpro_domain/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:52140864bcbd0c48deac82c5a43a667a72e67341ddd657823892e4fb2efb01d3 +size 195506 diff --git a/interpro_domain/advanced/plot_1.png b/interpro_domain/advanced/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..58f423f9f9ad0c65bbd953fdbed175bc179b8e75 --- /dev/null +++ b/interpro_domain/advanced/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:9c999679fab8a92ff4fa231dce9e9a42c38acd319b44546b6d1757e51d7331b7 +size 196159 diff --git a/interpro_domain/basic/idx2term.json b/interpro_domain/basic/idx2term.json new file mode 100644 index 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b/interpro_domain/basic/plot_8.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:33a66187f7664dd6e2e0ad98537b210f0f1c091afc5e24252119a1895c6e82b1 +size 145593 diff --git a/interpro_domain/consensus.joblib b/interpro_domain/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..ff7d415e96f822901f2e0ae1959e4970ca57e110 --- /dev/null +++ b/interpro_domain/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:6898378697f02201c3da93b38822823fb9c1ffc60e4cdbd833aa0df0b71b4508 +size 310515 diff --git a/interpro_domain/df_merge.tsv b/interpro_domain/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..1c339f4cac9ad07f464a94a7d16353545a5ad8d4 --- /dev/null +++ b/interpro_domain/df_merge.tsv @@ -0,0 +1,9 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +K Homology domain [IPR004087] 10 24 2.4711187978496074 0.0134691066127679 8.029126213592233 22.796116504854368 0.328818420881894 0.600646587147133 4.351556602822176 1.3994397166034702 0.8923876485619237 0.3352669927506027 0.203636451009126 1.0 0.2732850813359189 0.0010720436073174 2.2380734395490096e-06 +K Homology domain, type 1 [IPR004088] 14 25 2.454455132119253 0.0141098271336326 8.5 23.218446601941743 0.4539576731478794 0.576935027430011 4.690674491420825 1.6401661988255969 0.9187340965418598 0.3398774289684012 0.2091215881148182 1.0 0.2802926639431586 0.0012324742743759 3.03436196363312e-06 +Importin-alpha, importin-beta-binding domain [IPR002652] 3 5 2.148923203572935 0.0316404881232532 1.900485436893204 4.179611650485437 -0.0879924391494337 0.5961199277101574 1.2177090368111774 0.6874547431954602 0.834731806091852 0.3002594480637005 1.6933873035860414e-05 6.108202829893653e-06 4.656667989155393e-05 2.1451255431067108e-05 0.0003286021100258 +Glutathione S-transferase, C-terminal-like [IPR010987] 2 11 2.103588473516944 0.0354143602828445 3.949029126213592 11.37621359223301 -0.0908035435769439 0.5323098181486043 2.6346872162188446 1.2313530457632356 0.9588413776865506 0.2992576122582335 1.0 1.0 0.1432798584585485 0.0061570039439817 0.0397387250697101 +Cytochrome b5-like heme/steroid binding domain [IPR001199] 4 5 2.079564438003141 0.0375655016550349 2.813106796116505 6.104368932038835 1.6405397264547834 0.1100883340733615 1.2852875686886795 0.8042848477475721 1.100790504333474 0.1612592696854457 0.0029333243921292 0.0573151884822011 0.0001778916397324 0.0001405335592956 0.0001575214550341 +Peptidase M1, membrane alanine aminopeptidase [IPR014782] 4 6 2.0492681978473724 0.0404358966063769 2.121359223300971 5.466019417475728 1.4317001483019938 0.1783942022754649 1.021530403905949 0.5881604361499402 0.986353205880356 0.2226891741813114 0.053639682462237 0.0385773062479974 0.0743799864466655 0.1775366954381628 1.3106068439724131e-05 +Aminopeptidase N-like , N-terminal domain [IPR045357] 4 6 2.0492681978473724 0.0404358966063769 2.121359223300971 5.466019417475728 1.4317001483019938 0.1783942022754649 1.021530403905949 0.5881604361499402 0.986353205880356 0.2226891741813114 0.053639682462237 0.0385773062479974 0.0743799864466655 0.1775366954381628 1.3106068439724131e-05 +Major facilitator superfamily domain [IPR020846] 3 6 1.9746318978282709 0.0483099364679044 1.8883495145631068 4.121359223300971 0.8776223597987594 0.2728824130413255 1.233496960525634 1.4580976091979958 1.2936014196902064 0.266909732326598 0.0011017003564739 0.0093923264669034 0.0028960612595367 0.0348798008289802 0.0553856285019619 diff --git a/interpro_domain/metrics.json b/interpro_domain/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..5cec6a488cf8bb6aed27fc6bb16c886aab5396c1 --- /dev/null +++ b/interpro_domain/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2812, + "annotations_size": 2406, + "title": "Average number of proteins per term", + "value": 2.117206982543641 +} \ No newline at end of file diff --git a/interpro_domain/paths.json b/interpro_domain/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..42825a9d05589a5d5bb8513d31bc515f95d1a2d7 --- /dev/null +++ b/interpro_domain/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C428/C428_val_log2fc"} \ No newline at end of file diff --git a/interpro_domain/result.tsv b/interpro_domain/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c2467546d78d7a9234149f4f019bcc10947d1844 --- /dev/null +++ b/interpro_domain/result.tsv @@ -0,0 +1,201 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +K Homology domain [IPR004087] 0.5922644896176035 2.4711187978496074 0.0134691066127679 0.9999999999999932 0.1139359320270197 24 O75179,Q06787,Q96PU8,P51116,Q92945,P61978,O75525,Q96I24,P51114,Q07666 10 +K Homology domain, type 1 [IPR004088] 0.5752663539568165 2.454455132119253 0.0141098271336326 0.9999999999999986 0.1158276850884974 25 O75179,Q06787,Q8N9N2,Q96PU8,P51116,O00425,Q92945,P61978,O75525,Q96I24,P51114,Q9Y6M1,Q07666,Q96AE4 14 +Importin-alpha, importin-beta-binding domain [IPR002652] 0.9176634815703018 2.148923203572935 0.0316404881232532 1.0 0.161628480731523 5 O00505,O00629,P52294 3 +Glutathione S-transferase, C-terminal-like [IPR010987] 0.6985700746218859 2.1035884735169437 0.0354143602828445 1.0 0.1710982948604897 11 P78417,Q9H7Z7 2 +Cytochrome b5-like heme/steroid binding domain [IPR001199] 0.899893124332025 2.079564438003141 0.0375655016550349 1.0 0.1752393602139337 5 Q8WUJ1,O15173,Q9UMX5,O43169 4 +Peptidase M1, membrane alanine aminopeptidase [IPR014782] 0.8212779723845033 2.0492681978473724 0.0404358966063769 1.0 0.1814445122781584 6 Q9UIQ6,P55786,P09960,Q6P179 4 +Aminopeptidase N-like , N-terminal domain [IPR045357] 0.8212779723845033 2.0492681978473724 0.0404358966063769 1.0 0.1814445122781584 6 Q9UIQ6,P55786,P09960,Q6P179 4 +Major facilitator superfamily domain [IPR020846] 0.803558260149732 1.9746318978282709 0.0483099364679044 1.0 0.2020789250013052 6 P53985,Q8NHS3,Q5SR56 3 +Glutathione S-transferase, N-terminal [IPR004045] 0.7601347537465126 1.959556471329725 0.05004765330281 1.0 0.2069585805808564 7 P78417,Q9H7Z7 2 +Immunoglobulin-like domain [IPR007110] 0.6897991519066345 1.9304894193940836 0.0535462249515932 1.0 0.2125944178771176 10 P10321,P55899,P01889,P35613,Q9Y624,P04439 6 +Zinc finger, RanBP2-type [IPR001876] 0.6842331572472559 1.788583716006373 0.073681882292935 1.0 0.2525336307646748 9 Q01844,P35637,P98175,Q92804 4 +RNA recognition motif domain [IPR000504] 0.3780943250263766 1.7810638075719618 0.0749020274444776 1.0 0.2548999689270341 112 P52597,O14979,P38159,Q13310,P35637,P23588,P43243,Q9Y6M1,P22626,P31943,P11940,P55795,Q13242,P31483,Q9UHX1,Q92804,O60506,Q4G0J3,P52756,O43390,Q99729,Q9BWF3,P51991,Q14011,Q14103,Q01844,P98175,P31942,P62995,P98179,Q01085,Q96PK6 32 +Fragile X-related 1 protein, C-terminal region 1 [IPR032172] 0.951957295373668 1.758434834126742 0.0786735504549116 1.0 0.2629251317231654 2 P51114 1 +RNA recognition motif domain, eukaryote [IPR003954] 0.5994223252477137 1.7302570267759745 0.0835843636834723 1.0 0.2681386386965792 13 P11940,P38159,Q13310,P31483,Q9UHX1,Q14011 6 +Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862] 0.9441281138790056 1.7264113510662955 0.0842734351160052 1.0 0.2690723829502813 2 Q32P28 1 +Glycoside hydrolase 35, catalytic domain [IPR031330] 0.9434163701067636 1.7234980663625985 0.0847984945480808 1.0 0.2695180685372292 2 Q8IW92 1 +Phospholipase D/Transphosphatidylase [IPR001736] 0.9423487544484016 1.7191275190771442 0.0855911549313568 1.0 0.2700208909992507 2 Q8IV08 1 +Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337] 0.9245551601423484 1.6461843605536597 0.0997258081500418 1.0 0.2874931042767934 2 O60506 1 +Guanylate kinase/L-type calcium channel beta subunit [IPR008145] 0.7913048432684406 1.645369200447852 0.0998936970803821 1.0 0.2874931042767934 5 Q9NZW5,Q14168,O14936 3 +Guanylate kinase-like domain [IPR008144] 0.7913048432684406 1.645369200447852 0.0998936970803821 1.0 0.2874931042767934 5 Q9NZW5,Q14168,O14936 3 +MHC class I-like antigen recognition-like [IPR011161] 0.8871082621082568 1.6122517880371663 0.1069071599367319 1.0 0.2980517112488726 4 P55899,P01889,P04439 3 +Immunoglobulin C1-set [IPR003597] 0.8871082621082568 1.6122517880371663 0.1069071599367319 1.0 0.2980517112488726 4 P55899,P01889,P04439 3 +RBM3/CIRBP, RNA recognition motif [IPR034278] 0.91245551601424 1.5964906931212774 0.1103792820129438 1.0 0.3028193301290114 2 Q14011 1 +Reticulon [IPR003388] 0.9078291814946656 1.577474598436556 0.1146863624278788 1.0 0.311439489843653 2 O95197 1 +B30.2/SPRY domain [IPR001870] 0.6407641220522117 1.5746961365899472 0.1153266000185226 1.0 0.3124727473474837 9 O15344,Q14258,P19474,Q1KMD3 4 +SPRY domain [IPR003877] 0.6407641220522117 1.5746961365899472 0.1153266000185226 1.0 0.3124727473474837 9 O15344,Q14258,P19474,Q1KMD3 4 +Glutathione S-transferase, C-terminal [IPR004046] 0.6322869943079006 1.5325415440562258 0.1253888539969834 1.0 0.3332338347852791 9 P78417 1 +L27 domain [IPR004172] 0.8615887284167849 1.515047308890242 0.1297604238773468 1.0 0.3367891907755087 4 Q14168,O14936 2 +L27 domain, C-terminal [IPR014775] 0.8615887284167849 1.515047308890242 0.1297604238773468 1.0 0.3367891907755087 4 Q14168,O14936 2 +TRAM/LAG1/CLN8 homology domain [IPR006634] 0.8900355871886219 1.5042795358596175 0.132509405974633 1.0 0.3395288932640756 2 Q96G23 1 +Ion transporter-like, CBS domain [IPR044751] 0.8896797153024895 1.5028150005660998 0.1328867566133942 1.0 0.3397720897043852 2 Q8NE01 1 +CNNM, transmembrane domain [IPR002550] 0.8896797153024895 1.5028150005660998 0.1328867566133942 1.0 0.3397720897043852 2 Q8NE01 1 +B-box-type zinc finger [IPR000315] 0.6901625814889605 1.4840857559442124 0.1377861715630246 1.0 0.3456831124662298 6 P19474 1 +SET domain [IPR001214] 0.6881835004112326 1.4753535512316205 0.1401175161626704 1.0 0.3464776401720298 6 Q9BYW2,Q03164,O96028 3 +ERAP1-like C-terminal domain [IPR024571] 0.8486467236467139 1.4655954367685229 0.1427585351731908 1.0 0.3504867710476501 4 Q9UIQ6,P55786,Q6P179 3 +AWS domain [IPR006560] 0.8779359430605049 1.4544799644304398 0.1458132843046899 1.0 0.3568939593459655 2 O96028 1 +Zinc finger, CHHC-type [IPR012996] 0.9394802420790316 1.4522151174934543 0.1464418005062295 1.0 0.3577045401197851 3 P31943,P52597 2 +CARG-binding factor, N-terminal [IPR012956] 0.8750889679715312 1.4427621503463457 0.1490874847589189 1.0 0.3630612230060314 2 Q99729 1 +Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791] 0.8725978647686944 1.432509497834365 0.1519980619010712 1.0 0.3690285942825201 2 Q9NVE7 1 +Isopropylmalate dehydrogenase-like domain [IPR024084] 0.8390366092740751 1.4288214842023483 0.1530555489331098 1.0 0.3710466953478706 4 P48735 1 +KHDRBS, Qua1 domain [IPR032571] 0.866903914590747 1.409077592325294 0.1588122258421545 1.0 0.3760519656856069 2 Q07666 1 +Sam68, tyrosine-rich domain [IPR032335] 0.866903914590747 1.409077592325294 0.1588122258421545 1.0 0.3760519656856069 2 Q07666 1 +Survival motor neuron [IPR010304] 0.861565836298931 1.3871155581813812 0.1654065286001942 1.0 0.3827651423267089 2 O75940 1 +Alpha-L-fucosidase, C-terminal [IPR031919] 0.8594306049822151 1.378332726868318 0.1681005832940041 1.0 0.3851904794336894 2 Q9BTY2 1 +Post-SET domain [IPR003616] 0.8241829898770809 1.37191478163803 0.1700899682340306 1.0 0.387901861204813 4 Q03164,O96028 2 +MD-2-related lipid-recognition domain [IPR003172] 0.8523131672597872 1.349067305287513 0.1773153486260035 1.0 0.3972260044638402 2 P17900 1 +PABP, RNA recognition motif 2 [IPR045305] 0.8508896797153012 1.3432165420477604 0.1792018667873742 1.0 0.4010787827817883 2 Q13310 1 +Tubulin/FtsZ, 2-layer sandwich domain [IPR018316] 0.8063443746058448 1.3035067198458916 0.1924018237166755 1.0 0.4189310297396574 4 Q9BVA1,P07437 2 +Tubulin/FtsZ, GTPase domain [IPR003008] 0.8063443746058448 1.3035067198458916 0.1924018237166755 1.0 0.4189310297396574 4 Q9BVA1,P07437 2 +Acyl-CoA oxidase, C-terminal [IPR002655] 0.8373665480427062 1.2876854558604762 0.1978554784113486 1.0 0.4254158007664922 2 O15254 1 +Zinc finger C2H2 AKAP95-type [IPR034736] 0.8935564257743009 1.2837262281210593 0.199237763939132 1.0 0.4273189070310756 3 Q9ULX6,O43823 2 +GMP phosphodiesterase, delta subunit [IPR008015] 0.8934073378491953 1.2831797396824145 0.1994291123728846 1.0 0.4273189070310756 3 A6NIH7 1 +OCRE domain [IPR041591] 0.8355871886121061 1.280386972243283 0.200409073463436 1.0 0.4278942738384472 2 P98175 1 +MHC class I alpha chain, alpha1 alpha2 domains [IPR001039] 0.8867924528301944 1.258940457750245 0.208051839158192 1.0 0.4375635708169668 3 P01889,P04439 2 +MHC class I, alpha chain, C-terminal [IPR010579] 0.8867924528301944 1.258940457750245 0.208051839158192 1.0 0.4375635708169668 3 P01889,P04439 2 +Tudor domain [IPR002999] 0.6025885176168068 1.233586325627956 0.2173570910639881 1.0 0.4485898009756484 7 Q12888,O75940,Q14739,Q16637 4 +Phospholipid/glycerol acyltransferase [IPR002123] 0.6897004185932325 1.2268456654060458 0.2198806036074834 1.0 0.4529389831161002 5 Q8NF37 1 +SPRY-associated [IPR006574] 0.7852540319851418 1.2226265063731925 0.221470796945431 1.0 0.4531111713016217 4 O15344,P19474 2 +Butyrophylin-like, SPRY domain [IPR003879] 0.7852540319851418 1.2226265063731925 0.221470796945431 1.0 0.4531111713016217 4 O15344,P19474 2 +Fxr1, tudor domain [IPR041560] 0.8743325026699966 1.2133347167636144 0.2250018748299735 1.0 0.4556856151859565 3 P51116,P51114 2 +Fragile X-related 1 protein, C-terminal core [IPR022034] 0.8743325026699966 1.2133347167636144 0.2250018748299735 1.0 0.4556856151859565 3 P51116,P51114 2 +Synaptic functional regulator FMRP, KH0 domain [IPR040472] 0.8743325026699966 1.2133347167636144 0.2250018748299735 1.0 0.4556856151859565 3 P51116,P51114 2 +Agenet-like domain [IPR008395] 0.8743325026699966 1.2133347167636144 0.2250018748299735 1.0 0.4556856151859565 3 P51116,P51114 2 +PB1 domain [IPR000270] 0.8174377224199298 1.2060901481343207 0.227782733098252 1.0 0.4593841205652929 2 Q13501 1 +Prolyl 4-hydroxylase, alpha subunit [IPR006620] 0.7741515238894369 1.1800895116065315 0.2379646156759509 1.0 0.4696824161741904 4 Q32P28 1 +Oxoglutarate/iron-dependent dioxygenase [IPR005123] 0.7741515238894369 1.1800895116065315 0.2379646156759509 1.0 0.4696824161741904 4 Q32P28 1 +Ataxin-2, C-terminal [IPR009818] 0.770323205893024 1.1654338820811494 0.2438434090798664 1.0 0.4724231477310595 4 Q9BPZ3 1 +ZU5 domain [IPR000906] 0.8049822064056941 1.1553004468402517 0.2479674130458953 1.0 0.4780525607279039 2 Q12955 1 +Zinc finger, PHD-finger [IPR019787] 0.4678858706242527 1.1189003965867304 0.2631826337746838 1.0 0.5001717352779538 17 Q03164,O96028 2 +Cold-shock (CSD) domain [IPR019844] 0.8477368398284326 1.1163305771064922 0.2642806577551226 1.0 0.5005631886600457 3 P16989 1 +Glycoside hydrolase family 2, catalytic domain [IPR006103] 0.7946619217081998 1.113375847217036 0.2655470437013365 1.0 0.5007101780136487 2 P08236 1 +CBS domain [IPR000644] 0.6555509830194992 1.08536223757018 0.2777612505856135 1.0 0.5113187214299817 5 Q8NE01,Q6P4Q7 2 +DnaJ domain [IPR001623] 0.4616724177955711 1.0786304095823454 0.2807525194662277 1.0 0.512511807159138 17 O75937,O60884,O14976,Q9UBS4,Q8WXX5,Q99543 6 +Proteasome alpha-subunit, N-terminal domain [IPR000426] 0.5695943914393442 1.0780240648467938 0.2810230168778727 1.0 0.5126166630842772 7 P60900 1 +Alpha/beta hydrolase fold-1 [IPR000073] 0.743157328548635 1.0617144457035907 0.2883653393355225 1.0 0.5208854051265497 4 P07099 1 +Polyketide synthase, enoylreductase domain [IPR020843] 0.563871220293723 1.051054518261157 0.2932335513245063 1.0 0.5257227455191968 7 Q8N4Q0 1 +EB1, C-terminal [IPR004953] 0.7765124555160293 1.040082592236118 0.2983015304518219 1.0 0.5308531673573104 2 Q15555 1 +FF domain [IPR002713] 0.7736654804270442 1.0286445210539383 0.3036467489014369 1.0 0.5383744125695337 2 O75400 1 +Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004] 0.8108697896180743 0.9831251007023052 0.3255458719224726 1.0 0.5615949825837417 3 Q13310 1 +Cold-shock protein, DNA-binding [IPR002059] 0.7221873829800936 0.982157237560385 0.3260223908800443 1.0 0.5615949825837417 4 P16989 1 +Cold shock domain [IPR011129] 0.7221873829800936 0.982157237560385 0.3260223908800443 1.0 0.5615949825837417 4 P16989 1 +Alanyl-tRNA synthetase, class IIc, N-terminal [IPR018164] 0.7601423487544646 0.9745691334738243 0.329774030785475 1.0 0.56198882804678 2 Q5JTZ9 1 +SKP1 component, POZ domain [IPR016073] 0.7569395017793746 0.961829074965588 0.3361354704491568 1.0 0.5695365788032897 2 Q15369 1 +VHS domain [IPR002014] 0.8006709146435746 0.9466479735147622 0.3438181895697125 1.0 0.5760630669252983 3 Q92783 1 +Zinc finger, C3HC4 RING-type [IPR018957] 0.7998908725510874 0.94386622426822 0.3452380137918398 1.0 0.5776374556211172 3 Q9H000 1 +Far upstream element-binding protein, C-terminal [IPR015096] 0.7505338078291997 0.9364339786563928 0.3490497901731682 1.0 0.5779876801362074 2 Q92945 1 +Immunoglobulin subtype 2 [IPR003598] 0.6179987906740531 0.9307472370638687 0.3519843286470241 1.0 0.5783183715775281 5 P35613,Q9Y624 2 +Immunoglobulin subtype [IPR003599] 0.6179987906740531 0.9307472370638687 0.3519843286470241 1.0 0.5783183715775281 5 P35613,Q9Y624 2 +Tyrosine-specific protein phosphatases domain [IPR000387] 0.7065593968419235 0.923290535634937 0.3558558187111824 1.0 0.5816502036814571 4 Q06124 1 +Protein-tyrosine phosphatase, catalytic [IPR003595] 0.6032661347955754 0.8706700530733326 0.3839343344032975 1.0 0.6105393315098042 5 Q9Y217,Q06124 2 +Elp3/MiaB/NifB [IPR006638] 0.7220640569394998 0.8251615653007712 0.4092798708375746 1.0 0.6300239086597599 2 Q9H9T3 1 +Radical SAM [IPR007197] 0.7220640569394998 0.8251615653007712 0.4092798708375746 1.0 0.6300239086597599 2 Q9H9T3 1 +Tyrosine-specific protein phosphatase, PTPase domain [IPR000242] 0.7637273682891424 0.8164311930840994 0.4142535620767806 1.0 0.6340293068427062 3 Q06124 1 +La-type HTH domain [IPR006630] 0.5845653087203403 0.7951365864499644 0.4265340543995344 1.0 0.6425876218834892 5 Q71RC2,Q92615,Q4G0J3 3 +Alcohol dehydrogenase-like, C-terminal [IPR013149] 0.5081410131614378 0.7905984786532552 0.4291783349029456 1.0 0.6445712071014277 7 Q8N4Q0 1 +GRAM domain [IPR004182] 0.7530800880209885 0.7795890591824987 0.4356327978338581 1.0 0.6502062726974334 3 Q66K14 1 +Zinc finger, PHD-type [IPR001965] 0.3989836817066715 0.737378161595933 0.4608924121306219 1.0 0.6710831276476932 19 Q03164,O96028 2 +Thioredoxin domain [IPR013766] 0.3676610467179695 0.7153815918890511 0.4743732839745016 1.0 0.6842578664524286 23 O95881 1 +Ubiquitin specific protease domain [IPR028889] 0.4115589155064142 0.7129301417991798 0.4758889863511513 1.0 0.6855969729308878 15 Q96K76,Q9UPU5,Q8TEY7,Q96RU2 4 +Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394] 0.4115589155064142 0.7129301417991798 0.4758889863511513 1.0 0.6855969729308878 15 Q96K76,Q9UPU5,Q8TEY7,Q96RU2 4 +Chaperone DnaJ, C-terminal [IPR002939] 0.5627270498865 0.7082912137046636 0.4787644322608637 1.0 0.6855969729308878 5 O60884 1 +Vicinal oxygen chelate (VOC) domain [IPR037523] 0.6911032028469907 0.707902138901403 0.4790060313785629 1.0 0.6855969729308878 2 Q9HC38 1 +Zinc finger, RING-type [IPR001841] 0.3565241458942679 0.6337514544719741 0.5262430391978095 1.0 0.7140056427440178 23 O15344,Q5VTR2,Q9H000,O96028,P19474,Q14258,Q9UBS8 7 +Ancestral coatomer element 1, Sec16/Sec31 [IPR024298] 0.6683274021352416 0.6248802602571827 0.5320496488578921 1.0 0.7165399491473509 2 O15027 1 +MIT domain [IPR007330] 0.7026295551325513 0.6107504931106372 0.5413647727215791 1.0 0.7208210532197673 3 Q8N0X7 1 +Peptidase M3A/M3B catalytic domain [IPR001567] 0.7009611961552226 0.6053604860685285 0.5449394998182422 1.0 0.7239736852849488 3 P52888,Q9BYT8 2 +EF-hand, Ca insensitive [IPR014837] 0.6996349664793747 0.6010859517247729 0.5477827397079256 1.0 0.7243355869109165 3 O43707 1 +Proteasome activator PA28, N-terminal domain [IPR003185] 0.6986471175756438 0.5979079432511784 0.549901359461868 1.0 0.7253633063954247 3 Q9UL46 1 +Proteasome activator PA28, C-terminal domain [IPR003186] 0.6986471175756438 0.5979079432511784 0.549901359461868 1.0 0.7253633063954247 3 Q9UL46 1 +Peptidase S9A, N-terminal domain [IPR023302] 0.6576512455515993 0.5870980581418421 0.5571378516763432 1.0 0.7256211900403913 2 P48147 1 +CSN8/PSMD8/EIF3K [IPR033464] 0.6882436429582525 0.5647547473288169 0.5722405906902777 1.0 0.7288569937537365 3 Q99627 1 +DNA mismatch repair protein MutS, clamp [IPR007861] 0.6501779359430602 0.5611302099253878 0.5747087751001785 1.0 0.7289735787562879 2 P52701 1 +Myosin tail [IPR002928] 0.6391459074733076 0.5235731805723369 0.6005754392996314 1.0 0.7437788449452045 2 P35580 1 +Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778] 0.673905304378795 0.5200689913014827 0.6030154900524882 1.0 0.7438577989584768 3 Q1KMD3,Q00839 2 +Exoribonuclease, phosphorolytic domain 1 [IPR001247] 0.4571802115115873 0.4718075414562852 0.6370641674939277 1.0 0.7596780484221531 6 Q96B26 1 +Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375] 0.6578853684585282 0.4716597073818241 0.6371697014613071 1.0 0.7596780484221531 3 P13798,P48147 2 +Peptidase M28 [IPR007484] 0.6479174083303755 0.4424203942743796 0.6581850237673159 1.0 0.7691262174052669 3 P02786,Q7Z2K6 2 +High mobility group box domain [IPR009071] 0.3775121293366457 0.3911559626279307 0.6956819569976009 1.0 0.796294380845018 11 O96028 1 +14-3-3 domain [IPR023410] 0.4354953670705573 0.3889432256894514 0.6973181452731891 1.0 0.7977876640643333 6 P31946,P61981,P62258,P63104,Q04917 5 +Chromo domain subgroup [IPR017984] 0.6197935208259199 0.3639868607495716 0.7158678209969831 1.0 0.8105308128558782 3 P83916,P45973 2 +Chromo shadow domain [IPR008251] 0.6197935208259199 0.3639868607495716 0.7158678209969831 1.0 0.8105308128558782 3 P83916,P45973 2 +Pentacotripeptide-repeat region of PRORP [IPR033443] 0.5879003558718799 0.3633429448592051 0.7163487168208023 1.0 0.8106937971170509 2 O75127 1 +Arf GTPase activating protein [IPR001164] 0.6088286344223349 0.3351822953559556 0.7374875766063946 1.0 0.8310984118571361 3 Q8N6H7 1 +4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896] 0.6032495276519393 0.3209368281338575 0.7482582641751945 1.0 0.8410152624842163 3 P21912 1 +Plectin/S10, N-terminal [IPR005326] 0.5725978647686762 0.3207699453849517 0.7483847368988807 1.0 0.8410152624842163 2 P46783 1 +Glutaredoxin, PICOT-like [IPR033658] 0.5701067615658293 0.3140959095354865 0.7534481961618609 1.0 0.8459152403011839 2 Q86SX6 1 +Fibronectin type III [IPR003961] 0.414277736602073 0.3125984658607055 0.7545857438226329 1.0 0.8460080613407525 6 O15344,P15260 2 +PIK-related kinase, FAT [IPR003151] 0.5989768142844951 0.310220186689701 0.7563935205070074 1.0 0.8468510052768077 3 P42345 1 +FATC domain [IPR003152] 0.5989768142844951 0.310220186689701 0.7563935205070074 1.0 0.8468510052768077 3 P42345 1 +PIK-related kinase [IPR014009] 0.5989768142844951 0.310220186689701 0.7563935205070074 1.0 0.8468510052768077 3 P42345 1 +EF-hand domain [IPR002048] 0.2982011830811519 0.3080509542546885 0.7580435603880629 1.0 0.8481788437319886 40 Q14257,O43852,Q8NF37,P60660,Q66K14,Q96D71,P80303,Q9H223 8 +26S proteasome regulatory subunit Rpn7, N-terminal [IPR045135] 0.566192170818498 0.3037575445393421 0.7613126138079509 1.0 0.8499852198709651 2 Q15008 1 +B-box, C-terminal [IPR003649] 0.5195624081296228 0.2958585463240671 0.7673381097647218 1.0 0.8550286140873139 4 O15344,O15164 2 +PTB/PI domain [IPR006020] 0.5753781512308855 0.2541857975247754 0.7993520222896837 1.0 0.8779101816858662 3 Q9UKG1 1 +Nucleoporin, Nup133/Nup155-like, C-terminal [IPR007187] 0.5437722419928737 0.2481860535306156 0.8039904565166489 1.0 0.8818256047198483 2 O75694 1 +AP complex, mu/sigma subunit [IPR022775] 0.3924744427094533 0.2399799345818553 0.8103458120207869 1.0 0.8874337841247216 6 Q92572 1 +Cation-transporting P-type ATPase, C-terminal [IPR006068] 0.568529725881099 0.238966283178691 0.8111317275073899 1.0 0.8874865558812097 3 P05023,P16615 2 +Cation-transporting P-type ATPase, N-terminal [IPR004014] 0.568529725881099 0.238966283178691 0.8111317275073899 1.0 0.8874865558812097 3 P05023,P16615 2 +GTP binding domain [IPR006073] 0.3407844011837203 0.2273571777596639 0.820146015570105 1.0 0.8965339906686383 11 Q9NTK5 1 +Alanyl-tRNA synthetase, class IIc, core domain [IPR018165] 0.5582458022377343 0.2170291606658201 0.8281856195738049 1.0 0.9028611693224172 3 Q5JTZ9 1 +UAS [IPR006577] 0.5291814946619157 0.2154843161184799 0.8293897387828204 1.0 0.9037643620975842 2 Q9UNN5 1 +NUC153 [IPR012580] 0.5252669039145853 0.20718995217928 0.835861514063698 1.0 0.9079380599716738 2 Q9BSC4 1 +EH domain [IPR000261] 0.415508728358317 0.2051320836305624 0.8374689302840732 1.0 0.9092735768337004 5 Q96D71 1 +Sorting nexin Vps5-like, C-terminal [IPR015404] 0.4779183656719624 0.1932821848522684 0.8467379776884598 1.0 0.917680889332628 4 Q9Y5X3 1 +Cyclin, N-terminal [IPR006671] 0.498932384341627 0.156761866877834 0.8754325270320047 1.0 0.9419904561891784 2 P14635 1 +Cyclin, C-terminal domain [IPR004367] 0.498932384341627 0.156761866877834 0.8754325270320047 1.0 0.9419904561891784 2 P14635 1 +Cyclin-like [IPR013763] 0.498932384341627 0.156761866877834 0.8754325270320047 1.0 0.9419904561891784 2 P14635 1 +Acyltransferase, C-terminal domain [IPR032098] 0.4914590747330924 0.1441632332268464 0.8853715732458827 1.0 0.9480213641431214 2 Q6UWP7 1 +EF hand associated, type-2 [IPR013567] 0.4900355871886024 0.1418490469391789 0.8871992418738401 1.0 0.9487117226437596 2 Q8IXI2 1 +EF hand associated, type-1 [IPR013566] 0.4900355871886024 0.1418490469391789 0.8871992418738401 1.0 0.9487117226437596 2 Q8IXI2 1 +MIRO domain [IPR020860] 0.4900355871886024 0.1418490469391789 0.8871992418738401 1.0 0.9487117226437596 2 Q8IXI2 1 +PurM-like, N-terminal domain [IPR016188] 0.4825622775800588 0.1301462325110684 0.8964507328921139 1.0 0.9572618609742553 2 P49903 1 +Diaphanous autoregulatory (DAD) domain [IPR014767] 0.4807829181494624 0.1274699188195953 0.8985684802423217 1.0 0.9572618609742553 2 Q9NSV4 1 +Formin, FH2 domain [IPR015425] 0.4807829181494624 0.1274699188195953 0.8985684802423217 1.0 0.9572618609742553 2 Q9NSV4 1 +Rho GTPase-binding/formin homology 3 (GBD/FH3) domain [IPR014768] 0.4807829181494624 0.1274699188195953 0.8985684802423217 1.0 0.9572618609742553 2 Q9NSV4 1 +Formin, GTPase-binding domain [IPR010473] 0.4807829181494624 0.1274699188195953 0.8985684802423217 1.0 0.9572618609742553 2 Q9NSV4 1 +Formin, FH3 domain [IPR010472] 0.4807829181494624 0.1274699188195953 0.8985684802423217 1.0 0.9572618609742553 2 Q9NSV4 1 +Fumarate lyase, N-terminal [IPR022761] 0.4765124555160116 0.1212182236464325 0.9035181901715184 1.0 0.9614616388998996 2 P07954 1 +Methylglyoxal synthase-like domain [IPR011607] 0.4736654804270333 0.1171841295606635 0.906714143041124 1.0 0.9633303715338728 2 P27708 1 +PDZ domain [IPR001478] 0.2918527568596658 0.1032875428155255 0.9177347621319298 1.0 0.9722896687315822 14 Q14168,O14936 2 +DNA-directed RNA polymerase, RpoA/D/Rpb3-type [IPR011263] 0.4608540925266834 0.1003337346565336 0.920079376227837 1.0 0.9739159609345251 2 P19387 1 +DNA-directed RNA polymerase, insert domain [IPR011262] 0.4608540925266834 0.1003337346565336 0.920079376227837 1.0 0.9739159609345251 2 P19387 1 +Myosin, N-terminal, SH3-like [IPR004009] 0.4855820576717659 0.0949891125708488 0.9243234747263886 1.0 0.9773963328348846 3 P35580,P35579 2 +PurM-like, C-terminal domain [IPR010918] 0.4827340690637214 0.0913947840774877 0.9271789061085948 1.0 0.9786924417320502 3 O15067,P49903 2 +E3 ligase, CCCH-type zinc finger [IPR041367] 0.4824709724599879 0.0910671664384913 0.9274392215914692 1.0 0.9786924417320502 3 Q86VM9 1 +Dynamin, GTPase domain [IPR001401] 0.481310074759695 0.0896304854393414 0.9285808580219956 1.0 0.9789826204654472 3 O00429,P50570 2 +Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant [IPR000866] 0.4166666666666684 0.0805848225225785 0.9357721368177392 1.0 0.9836032158949238 4 Q13162,P32119,P30048 3 +Peroxiredoxin, C-terminal [IPR019479] 0.4166666666666684 0.0805848225225785 0.9357721368177392 1.0 0.9836032158949238 4 Q13162,P32119,P30048 3 +PITH domain [IPR010400] 0.4395017793594304 0.0768058271823557 0.9387780150137636 1.0 0.985302885383403 2 Q9GZP4 1 +Tyrosine-protein kinase, catalytic domain [IPR020635] 0.4373665480427027 0.0747513888053096 0.9404125196579728 1.0 0.985302885383403 2 P41240 1 +PTBP1, RNA recognition motif 2-like [IPR021790] 0.4355871886120964 0.0730791295806138 0.9417431494261104 1.0 0.985302885383403 2 P14866 1 +Threonine-tRNA ligase catalytic core domain [IPR033728] 0.4352313167259776 0.0727489833087745 0.9420058687406784 1.0 0.985302885383403 2 Q9BW92 1 +UBX domain [IPR001012] 0.3555397221232547 0.0725841805126126 0.9421370156335338 1.0 0.985302885383403 5 Q9UNZ2,Q9BZE9,Q96CS3,Q9UNN5 4 +CoA-binding [IPR003781] 0.4330960854092507 0.0707980076245964 0.9435585175327748 1.0 0.985302885383403 2 P53597 1 +Sec24-like, trunk domain [IPR041742] 0.4327402135231324 0.0704778020019084 0.9438133680449864 1.0 0.985302885383403 2 O95486 1 +Suppressor of forked [IPR008847] 0.4295373665480415 0.0676589877683259 0.9460570974811102 1.0 0.985302885383403 2 Q12996 1 +RNA polymerase Rpb2, domain 4 [IPR007646] 0.4259786476868291 0.0646581695283873 0.9484461689725524 1.0 0.985302885383403 2 P30876 1 +RNA polymerase Rpb2, domain 5 [IPR007647] 0.4259786476868291 0.0646581695283873 0.9484461689725524 1.0 0.985302885383403 2 P30876 1 +Cyclic nucleotide-binding domain [IPR000595] 0.3988927325394414 0.0567823016644491 0.9547186124146368 1.0 0.9909633224631648 4 Q6P4Q7 1 +Exosome complex component, N-terminal domain [IPR025721] 0.4060498220640572 0.0502608086149217 0.9599145544700176 1.0 0.994640145587796 2 Q13868 1 +ATP-citrate lyase/succinyl-CoA ligase [IPR005811] 0.3888888888888864 0.0450907990835288 0.9640349352324512 1.0 0.9984795756217294 4 P53597,P53396,Q96I99 3 +FCP1 homology domain [IPR004274] 0.393594306049824 0.0431580144626221 0.9655755734879669 1.0 0.9992978915454458 2 Q3ZCQ8 1 +Ricin B, lectin domain [IPR000772] 0.3787641324882675 0.0344624500790233 0.9725083850462262 1.0 1.0 4 Q86SF2 1 +Exportin-2, central domain [IPR013713] 0.4211463154147384 0.033826508090197 0.973015497638507 1.0 1.0 3 O95373,P55060 2 +Translation initiation factor, beta propellor-like domain [IPR013979] 0.3717948717948708 0.0278260703343727 0.97780087289041 1.0 1.0 4 Q9BY44,Q9NV06,P55884 3 +Intermediate filament, rod domain [IPR039008] 0.3250450491084149 0.0263915572335404 0.978945028157653 1.0 1.0 5 P08670 1 +Pseudouridine synthase II, N-terminal [IPR002501] 0.3277580071174438 0.0232540991378444 0.9814475853836372 1.0 1.0 2 Q8WWH5 1 +PUA domain [IPR002478] 0.3277580071174382 0.0232540991378435 0.981447585383638 1.0 1.0 2 Q9Y221 1 +Ribosomal protein S7 domain [IPR023798] 0.3227758007117504 0.0225894229249594 0.9819777809595094 1.0 1.0 2 Q9Y2R9 1 +PPM-type phosphatase domain [IPR001932] 0.3645467173177931 0.0214899558567693 0.982854815679406 1.0 1.0 4 O15355,Q15750 2 +N-acetylgalactosaminyltransferase [IPR045885] 0.3963151656411804 0.0201190999195162 0.9839483636962982 1.0 1.0 3 Q86SF2 1 +Ran binding domain [IPR000156] 0.3596866096866112 0.0175537005267803 0.9859948926063156 1.0 1.0 4 Q9H6Z4,P49792,Q9UKX7 3 +Zinc finger, CCCH-type [IPR000571] 0.2699665572160721 0.0167435481325521 0.9866412056365536 1.0 1.0 13 Q9H000,Q86VM9,Q8IWR0 3 +PWWP domain [IPR000313] 0.2905213678852493 0.0153021684337256 0.9877911125265572 1.0 1.0 9 O96028,Q7Z4V5,P52701 3 +Glutamine amidotransferase type 2 domain [IPR017932] 0.3670345318618778 0.0092866671912947 0.992590418129996 1.0 1.0 3 Q06203,P08243 2 +DNA mismatch repair protein MutS-like, N-terminal [IPR007695] 0.3616945532217912 0.0078224083248476 0.9937586848204608 1.0 1.0 3 P43246,P52701 2 +DNA mismatch repair protein MutS, C-terminal [IPR000432] 0.3616945532217912 0.0078224083248476 0.9937586848204608 1.0 1.0 3 P43246,P52701 2 +DNA mismatch repair protein MutS, core [IPR007696] 0.3616945532217912 0.0078224083248476 0.9937586848204608 1.0 1.0 3 P43246,P52701 2 +DNA mismatch repair protein MutS, connector domain [IPR007860] 0.3616945532217912 0.0078224083248476 0.9937586848204608 1.0 1.0 3 P43246,P52701 2 +Dbl homology (DH) domain [IPR000219] 0.3189747241011074 0.0002623447159112 0.9997906792039672 1.0 1.0 3 O94887,Q14155 2 diff --git a/interpro_domain/selections.json b/interpro_domain/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..0083d1f6282e6aeb70a158f09a442547586c2e24 --- /dev/null +++ b/interpro_domain/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1-acyl-sn-glycerol-3-phosphate acyltransferase [IPR004552]", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain [IPR035724]", "116kDa U5 small nuclear ribonucleoprotein component, C-terminal [IPR035655]", "116kDa U5 small nuclear ribonucleoprotein component, N-terminal [IPR031950]", "14-3-3 domain [IPR023410]", "16S/18S rRNA aminocarboxypropyltransferase Tsr3, C-terminal [IPR007177]", "2-oxoacid dehydrogenase acyltransferase, catalytic domain [IPR001078]", "2-oxoglutarate dehydrogenase E1 component, N-terminal domain [IPR032106]", "26S proteasome non-ATPase regulatory subunit RPN1, C-terminal [IPR041433]", "26S proteasome regulatory subunit RPN2, C-terminal [IPR040623]", "26S proteasome regulatory subunit RPN5, C-terminal domain [IPR040896]", "26S proteasome regulatory subunit Rpn6, N-terminal [IPR040773]", "26S proteasome regulatory subunit Rpn7, N-terminal [IPR045135]", "26S proteasome regulatory subunit, C-terminal [IPR013586]", "2Fe-2S ferredoxin-type iron-sulfur binding domain [IPR001041]", "3'-5' exonuclease domain [IPR002562]", "3-beta hydroxysteroid dehydrogenase/isomerase [IPR002225]", "3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108]", "3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176]", "3-hydroxyisobutyrate dehydrogenase, NAD-binding domain [IPR029154]", "3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal [IPR001104]", "3-oxoacid CoA-transferase, subunit A [IPR012792]", "3-oxoacid CoA-transferase, subunit B [IPR012791]", "4'-phosphopantetheinyl transferase domain [IPR008278]", "40S ribosomal protein S11, N-terminal [IPR032440]", "40S ribosomal protein S4, C-terminal domain [IPR032277]", "40S ribosomal protein SA, C-terminal domain [IPR032281]", "4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]", "5'-3' exoribonuclease 1, SH3-like domain [IPR041385]", "5'-AMP-activated protein kinase alpha 1 catalytic subunit, C-terminal [IPR039137]", "6-phosphogluconate dehydrogenase, C-terminal [IPR006114]", "6-phosphogluconate dehydrogenase, NADP-binding [IPR006115]", "6-phosphogluconolactonase, DevB-type [IPR005900]", "60S ribosomal protein L10P, insertion domain [IPR040637]", "60S ribosomal protein L4, C-terminal domain [IPR025755]", "6S proteasome subunit Rpn6, C-terminal helix domain [IPR040780]", "A kinase-anchoring protein AKAP5 and AKAP12, calmodulin (CaM)-binding motif [IPR001573]", "AAA ATPase, AAA+ lid domain [IPR041569]", "AAA+ ATPase domain [IPR003593]", "AAR2, C-terminal [IPR033648]", "AAR2, N-terminal [IPR033647]", "AARP2CN [IPR012948]", "AATF leucine zipper-containing domain [IPR025160]", "ABC transporter type 1, transmembrane domain [IPR011527]", "ABC transporter-like, ATP-binding domain [IPR003439]", "ABC-transporter extension domain [IPR032781]", "ADAR1, first double-stranded RNA binding domain [IPR044456]", "ADAR1, third double-stranded RNA binding domain [IPR044457]", "ADNP, zinc finger domain [IPR045762]", "AGC-kinase, C-terminal [IPR000961]", "AIMP2, lysyl-tRNA synthetase binding domain [IPR031889]", "AIMP2, thioredoxin-like domain [IPR041503]", "ALIX V-shaped domain [IPR025304]", "AMP-binding enzyme, C-terminal domain [IPR025110]", "AMP-dependent synthetase/ligase [IPR000873]", "AMPK, C-terminal adenylate sensor domain [IPR032270]", "AP complex, mu/sigma subunit [IPR022775]", "AP-2 complex subunit mu, N-terminal [IPR043532]", "AP-3 complex subunit beta 1, serine-rich domain [IPR029394]", "AP-3 complex subunit beta, C-terminal domain [IPR029390]", "AP-3 complex subunit delta domain, metazoa [IPR010474]", "AP180 N-terminal homology (ANTH) domain [IPR011417]", "APC10/DOC domain [IPR004939]", "APPL1, BAR domain [IPR037929]", "ARHGEF1-like, PH domain [IPR041020]", "ARHGEF2, PH domain [IPR037806]", "ARID DNA-binding domain [IPR001606]", "ARMET, C-terminal [IPR019345]", "ARMET, N-terminal [IPR045332]", "ASCH domain [IPR007374]", "ATP synthase, F1 complex, alpha subunit nucleotide-binding domain [IPR033732]", "ATP synthase, alpha subunit, C-terminal [IPR000793]", "ATP-citrate lyase/succinyl-CoA ligase [IPR005811]", "ATP-citrate synthase, citrate-binding domain [IPR032263]", "ATP-cone domain [IPR005144]", "ATP-dependent DNA helicase RecQ, zinc-binding domain [IPR032284]", "ATP-dependent RNA helicase Ski2, C-terminal [IPR012961]", "ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain [IPR044728]", "ATP-dependent helicase, C-terminal [IPR006555]", "ATP-grasp fold [IPR011761]", "ATP-grasp fold, succinyl-CoA synthetase-type [IPR013650]", "ATP-sulfurylase PUA-like domain [IPR025980]", "ATP:guanido phosphotransferase, N-terminal [IPR022413]", "ATP:guanido phosphotransferase, catalytic domain [IPR022414]", "ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]", "ATPase, AAA-type, core [IPR003959]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain [IPR004100]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain [IPR000194]", "ATPase, V1 complex, subunit H, C-terminal [IPR011987]", "ATPase, dynein-related, AAA domain [IPR011704]", "ATPsynthase alpha/beta subunit, N-terminal extension [IPR031686]", "AWS domain [IPR006560]", "Acetyl-CoA carboxylase [IPR034733]", "Acetyl-CoA carboxylase, central domain [IPR013537]", "Acetyl-coA carboxylase zinc finger domain [IPR041010]", "Acetyl-coenzyme A carboxyltransferase, C-terminal [IPR011763]", "Acetyl-coenzyme A carboxyltransferase, N-terminal [IPR011762]", "Acetyl-coenzyme A synthetase, N-terminal domain [IPR032387]", "Acid ceramidase, N-terminal [IPR029130]", "Acinus, RNA recognition motif [IPR034257]", "Aconitase A, swivel domain [IPR044137]", "Aconitase A/isopropylmalate dehydratase small subunit, swivel domain [IPR000573]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain [IPR001030]", "Actin-depolymerising factor homology domain [IPR002108]", "Activator of Hsp90 ATPase, N-terminal [IPR015310]", "Acyl transferase [IPR014043]", "Acyl-CoA dehydrogenase family member 10/11, N-terminal [IPR041726]", "Acyl-CoA dehydrogenase/oxidase C-terminal [IPR009075]", "Acyl-CoA dehydrogenase/oxidase, N-terminal [IPR013786]", "Acyl-CoA oxidase, C-terminal [IPR002655]", "Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091]", "Acyl-CoA-binding protein, ACBP [IPR000582]", "Acyl-coenzyme A oxidase, N-terminal [IPR029320]", "Acylamino-acid-releasing enzyme, N-terminal domain [IPR045550]", "Acylglycerol kinase, C-terminal [IPR045579]", "Acyltransferase, C-terminal domain [IPR032098]", "Adaptor protein ClpS, core [IPR003769]", "Adenosine deaminase/editase [IPR002466]", "Adenylate cyclase-associated CAP, C-terminal [IPR013912]", "Adenylate cyclase-associated CAP, N-terminal [IPR013992]", "Adenylate kinase, active site lid domain [IPR007862]", "Adenylosuccinate lyase C-terminal [IPR019468]", "Afadin, cargo binding domain [IPR037977]", "Agenet-like domain [IPR008395]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal [IPR007886]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain [IPR007698]", "Alanyl-tRNA synthetase, class IIc, N-terminal [IPR018164]", "Alanyl-tRNA synthetase, class IIc, core domain [IPR018165]", "Alcohol dehydrogenase, N-terminal [IPR013154]", "Alcohol dehydrogenase-like, C-terminal [IPR013149]", "Aldehyde dehydrogenase domain [IPR015590]", "Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant [IPR000866]", "Alpha Spectrin, SH3 domain [IPR035825]", "Alpha crystallin/Hsp20 domain [IPR002068]", "Alpha galactosidase A, C-terminal beta-sandwich domain [IPR035373]", "Alpha-2-macroglobulin RAP, C-terminal [IPR010483]", "Alpha-2-macroglobulin RAP, domain 2 [IPR038001]", "Alpha-2-macroglobulin RAP, domain 3 [IPR037999]", "Alpha-2-macroglobulin receptor-associated protein, domain 1 [IPR009066]", "Alpha-D-phosphohexomutase, C-terminal [IPR005843]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain I [IPR005844]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain II [IPR005845]", "Alpha-D-phosphohexomutase, alpha/beta/alpha domain III [IPR005846]", "Alpha-L-fucosidase, C-terminal [IPR031919]", "Alpha-N-acetylglucosaminidase, C-terminal [IPR024732]", "Alpha-N-acetylglucosaminidase, N-terminal [IPR024240]", "Alpha-N-acetylglucosaminidase, tim-barrel domain [IPR024733]", "Alpha-glycerophosphate oxidase, C-terminal [IPR031656]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like [IPR027450]", "Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal [IPR024366]", "Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain [IPR024367]", "Alpha/beta hydrolase fold-1 [IPR000073]", "Amidohydrolase-related [IPR006680]", "Amidophosphoribosyltransferase, N-terminal [IPR035584]", "Amine oxidase [IPR002937]", "Amino acid permease, N-terminal [IPR013612]", "Amino acid permease/ SLC12A domain [IPR004841]", "Amino acid transporter, transmembrane domain [IPR013057]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding [IPR045462]", "Aminoacyl-tRNA synthetase, class II (D/K/N) [IPR004364]", "Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) [IPR002314]", "Aminoacyl-tRNA synthetase, class II [IPR006195]", "Aminoacyl-tRNA synthetase, class Ia [IPR002300]", "Aminoglycoside phosphotransferase [IPR002575]", "Aminomethyltransferase, folate-binding domain [IPR006222]", "Aminopeptidase N-like , N-terminal domain [IPR045357]", "Aminopeptidase P [IPR033740]", "Aminopeptidase P, N-terminal [IPR007865]", "Aminotransferase class V domain [IPR000192]", "Aminotransferase, class I/classII [IPR004839]", "Amyloidogenic glycoprotein, E2 domain [IPR024329]", "Amyloidogenic glycoprotein, copper-binding [IPR011178]", "Amyloidogenic glycoprotein, extracellular [IPR008154]", "Amyloidogenic glycoprotein, heparin-binding [IPR015849]", "Anaphase-promoting complex subunit 1, C-terminal [IPR041221]", "Anaphase-promoting complex subunit 2, C-terminal [IPR014786]", "Anaphase-promoting complex subunit 4, WD40 domain [IPR024977]", "Anaphase-promoting complex subunit 5 domain [IPR026000]", "Ancestral coatomer element 1, Sec16/Sec31 [IPR024298]", "Angiomotin, C-terminal [IPR024646]", "Anillin homology domain [IPR012966]", "Anillin, N-terminal domain [IPR031970]", "Anillin, PH domain [IPR037840]", "Anion-transporting ATPase-like domain [IPR025723]", "Ankyrin repeat and LEM domain-containing protein 2, LEM domain [IPR035006]", "Ankyrin, UPA domain [IPR040745]", "Ankyrin-3, death domain [IPR037971]", "Anoctamin, dimerisation domain [IPR032394]", "Anticodon-binding [IPR004154]", "Anticodon-binding domain [IPR019181]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal [IPR006190]", "ApaG domain [IPR007474]", "Apoptosis-antagonizing transcription factor, C-terminal [IPR012617]", "Archaeal primase DnaG/twinkle, TOPRIM domain [IPR034154]", "Arf GTPase activating protein [IPR001164]", "Arfaptin homology (AH) domain [IPR010504]", "Arginine N-methyltransferase 2-like domain [IPR026480]", "Arginyl tRNA synthetase N-terminal domain [IPR005148]", "Arginyl-tRNA synthetase, catalytic core domain [IPR035684]", "Ariadne domain [IPR045840]", "Armadillo repeat-containing domain [IPR006911]", "Aromatic amino acid beta-eliminating lyase/threonine aldolase [IPR001597]", "Asn/Gln amidotransferase [IPR018027]", "Asparagine synthase [IPR001962]", "Asparagine synthase, N-terminal domain [IPR033738]", "Aspartate/glutamate/uridylate kinase [IPR001048]", "Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain [IPR006131]", "Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding [IPR006132]", "Aspartic peptidase, DDI1-type [IPR019103]", "Aspartyl beta-hydroxylase/Triadin domain [IPR007943]", "Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic [IPR006075]", "Aspartyl/asparaginy/proline hydroxylase [IPR007803]", "Ataxin 2, SM domain [IPR025852]", "Ataxin-10 domain [IPR019156]", "Ataxin-2, C-terminal [IPR009818]", "Aurora-A binding [IPR015128]", "B-block binding subunit of TFIIIC [IPR007309]", "B-box, C-terminal [IPR003649]", "B-box-type zinc finger [IPR000315]", "B3/B4 tRNA-binding domain [IPR005146]", "B30.2/SPRY domain [IPR001870]", "BAP29/BAP31, transmembrane domain [IPR040463]", "BAR domain [IPR004148]", "BAT2, N-terminal [IPR009738]", "BCL-6 corepressor, PCGF1 binding domain [IPR032365]", "BCL-6 corepressor, non-ankyrin-repeat domain [IPR031628]", "BCNT-C domain [IPR011421]", "BCS1, N-terminal [IPR014851]", "BEACH domain [IPR000409]", "BING4, C-terminal domain [IPR012952]", "BOP1, N-terminal domain [IPR012953]", "BP28, C-terminal domain [IPR012954]", "BR140-related, PWWD domain [IPR035502]", "BRCT domain [IPR001357]", "BRICHOS domain [IPR007084]", "BRK domain [IPR006576]", "BRO1 domain [IPR004328]", "BRPF2, PHD domain [IPR042009]", "BRPF2, ePHD domain [IPR042004]", "BSD domain [IPR005607]", "BTB/Kelch-associated [IPR011705]", "BTB/POZ domain [IPR000210]", "BURAN domain [IPR045354]", "BZW1/2, W2 domain [IPR043510]", "Bacterial Ig-like, group 2 [IPR003343]", "Bacterial surface antigen (D15) [IPR000184]", "Band 4.1 domain [IPR019749]", "Band 4.1, C-terminal [IPR008379]", "Band 7 domain [IPR001107]", "Band 7, C-terminal extension [IPR032435]", "Bap31/Bap29 cytoplasmic coiled-coil domain [IPR041672]", "Beta-Casp domain [IPR022712]", "Beta-adaptin appendage, C-terminal subdomain [IPR015151]", "Beta-amyloid precursor protein C-terminal [IPR019543]", "Beta-catenin-like protein 1, N-terminal [IPR013180]", "Beta-galactosidase jelly roll domain [IPR025300]", "Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019]", "Beta-ketoacyl synthase, C-terminal [IPR014031]", "Beta-ketoacyl synthase, N-terminal [IPR014030]", "Beta-mannosidase, Ig-fold domain [IPR041625]", "Beta-trefoil DNA-binding domain [IPR015350]", "Bifunctional delta 1-pyrroline-5-carboxylate synthetase, glutamate-5-kinase domain [IPR041744]", "Biliverdin reductase, catalytic [IPR015249]", "Biotin carboxylase, C-terminal [IPR005482]", "Biotin carboxylase-like, N-terminal domain [IPR005481]", "Biotin carboxylation domain [IPR011764]", "Biotin protein ligase, C-terminal [IPR003142]", "Biotin-protein ligase, N-terminal [IPR019197]", "Biotin/lipoyl attachment [IPR000089]", "Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain [IPR004143]", "Bms1/Tsr1-type G domain [IPR030387]", "Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal [IPR018955]", "Brdt, bromodomain, repeat I [IPR043508]", "Brdt, bromodomain, repeat II [IPR043509]", "Brix domain [IPR007109]", "Bromo adjacent homology (BAH) domain [IPR001025]", "Bromodomain [IPR001487]", "Bromodomain adjacent to zinc finger domain protein 1A, bromodomain [IPR037325]", "Brr2, N-terminal helicase PWI domain [IPR041094]", "Bud22 domain [IPR015158]", "Butyrophylin-like, SPRY domain [IPR003879]", "C-CAP/cofactor C-like domain [IPR017901]", "C-terminal associated domain of TOPRIM [IPR031660]", "C-type lectin-like [IPR001304]", "C2 DOCK-type domain [IPR027007]", "C2 domain [IPR000008]", "C2 phosphatidylinositol 3-kinase-type domain [IPR002420]", "C4-type zinc-finger of DNA polymerase delta [IPR025687]", "CAAX prenyl protease 1, N-terminal [IPR032456]", "CAP Gly-rich domain [IPR000938]", "CAPN2, penta-EF hand, calcium binding motif [IPR042736]", "CARG-binding factor, N-terminal [IPR012956]", "CARP motif [IPR006599]", "CASK, SH3 domain [IPR035473]", "CBS domain [IPR000644]", "CCAAT-binding factor [IPR005612]", "CCDC93, coiled-coil domain [IPR019159]", "CCR4-NOT transcription complex subunit 1, CAF1-binding domain [IPR032191]", "CCR4-NOT transcription complex subunit 1, HEAT repeat [IPR032194]", "CCR4-NOT transcription complex subunit 1, TTP binding domain [IPR032193]", "CCR4-NOT transcription complex subunit 1, domain 4 [IPR024557]", "CCR4-Not complex component, Not1, C-terminal [IPR007196]", "CD2-associated protein, first SH3 domain [IPR035775]", "CD2-associated protein, second SH3 domain [IPR035776]", "CD2-associated protein, third SH3 domain [IPR035777]", "CD209-like, C-type lectin-like domain [IPR033989]", "CD47 immunoglobulin-like [IPR013270]", "CD47 transmembrane [IPR013147]", "CDC48, N-terminal subdomain [IPR003338]", "CDC48, domain 2 [IPR004201]", "CDH1/2, SANT-Helical linker 1 [IPR040793]", "CELF1/2, RNA recognition motif 1 [IPR034196]", "CELF1/2, RNA recognition motif 2 [IPR034198]", "CELF1/2, RNA recognition motif 3 [IPR034199]", "CENP-T/Histone H4, histone fold [IPR035425]", "CEP170, C-terminal [IPR029300]", "CFA20 domain [IPR007714]", "CHD subfamily II, SANT-like domain [IPR009462]", "CHD, C-terminal 2 [IPR012957]", "CHD, N-terminal [IPR012958]", "CHIP, N-terminal tetratricopeptide repeat domain [IPR041312]", "CHIP/LubX , U box domain [IPR045202]", "CHORD domain [IPR007051]", "CID domain [IPR006569]", "CIDE-N domain [IPR003508]", "CLASP N-terminal domain [IPR024395]", "CLU central domain [IPR033646]", "CLU domain [IPR025697]", "CNNM, transmembrane domain [IPR002550]", "COG complex component, COG2, C-terminal [IPR024603]", "COMM domain [IPR017920]", "COP9 signalosome complex subunit 4, helix turn helix domain [IPR041406]", "COP9 signalosome complex subunit 7, helix I [IPR041481]", "COS domain [IPR017903]", "CPL domain [IPR012959]", "CPSF2, metallo-hydrolase domain [IPR035639]", "CPSF7, RNA recognition motif [IPR034773]", "CRA domain [IPR013144]", "CRAL-TRIO lipid binding domain [IPR001251]", "CRAL/TRIO, N-terminal domain [IPR011074]", "CRIB domain [IPR000095]", "CRK, C-terminal SH3 domain [IPR035458]", "CRK, N-terminal SH3 domain [IPR035457]", "CS domain [IPR007052]", "CSK-like, SH2 domain [IPR035027]", "CSN8/PSMD8/EIF3K [IPR033464]", "CTLH, C-terminal LisH motif [IPR006595]", "CTLH/CRA C-terminal to LisH motif domain [IPR024964]", "CTP synthase GATase domain [IPR033828]", "CTP synthase, N-terminal [IPR017456]", "CYRIA/CYRIB, Rac1 binding domain [IPR009828]", "Cadherin prodomain [IPR014868]", "Cadherin, cytoplasmic domain [IPR000233]", "Cadherin-like [IPR002126]", "Calcineurin-like phosphoesterase domain, ApaH type [IPR004843]", "Calcineurin-like phosphoesterase domain, lpxH-type [IPR024654]", "Calcium/calmodulin-dependent protein kinase II, association-domain [IPR013543]", "Calcyclin-binding Protein, CS domain [IPR037893]", "Calpain subdomain III [IPR033883]", "Calponin homology domain [IPR001715]", "Caprin-1 dimerization domain [IPR041637]", "Carbamoyl-phosphate synthase large subunit, CPSase domain [IPR005483]", "Carbamoyl-phosphate synthase small subunit, GATase1 domain [IPR035686]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain [IPR002474]", "Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain [IPR005479]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain [IPR005480]", "Carbohydrate kinase PfkB [IPR011611]", "Carbon-nitrogen hydrolase [IPR003010]", "Carboxylase, conserved domain [IPR003379]", "Carboxypeptidase D, carboxypeptidase-like domain 2 [IPR034224]", "Carboxypeptidase D, carboxypeptidase-like domain 3 [IPR033848]", "Casein kinase substrate, phosphoprotein PP28 [IPR019380]", "Cathepsin C [IPR039412]", "Cathepsin C exclusion [IPR014882]", "Cation-transporting P-type ATPase, C-terminal [IPR006068]", "Cation-transporting P-type ATPase, N-terminal [IPR004014]", "Cation/H+ exchanger [IPR006153]", "Cationic amino acid transporter, C-terminal [IPR029485]", "Cdc23 [IPR007192]", "Cdc37, C-terminal [IPR013873]", "Cdc37, Hsp90 binding [IPR013874]", "Cdc37, N-terminal domain [IPR013855]", "Cell division control protein 73, C-terminal [IPR031336]", "Cell morphogenesis central region [IPR029473]", "Cell morphogenesis protein C-terminal [IPR025481]", "Cell morphogenesis protein N-terminal [IPR025614]", "Cellular tumor antigen p53, transactivation domain 2 [IPR040926]", "Centromere protein Cenp-F, N-terminal [IPR018463]", "Centromere protein Cenp-F, leucine-rich repeat-containing domain [IPR019513]", "Centrosomal CEP44 domain [IPR029157]", "Chaperone DnaJ, C-terminal [IPR002939]", "Chitinase II [IPR011583]", "Choline/carnitine acyltransferase domain [IPR039551]", "Choloylglycine hydrolase/NAAA C-terminal [IPR029132]", "Chromatin assembly factor 1 subunit B, C-terminal domain [IPR029129]", "Chromatin assembly factor 1 subunit p150, C-terminal [IPR029105]", "Chromatin assembly factor 1 subunit p150, N-terminal [IPR029091]", "Chromatin target of PRMT1 protein, C-terminal [IPR025715]", "Chromo domain [IPR023780]", "Chromo domain subgroup [IPR017984]", "Chromo shadow domain [IPR008251]", "Chromo/chromo shadow domain [IPR000953]", "Chromosome passenger complex (CPC) protein INCENP N-terminal [IPR022006]", "Chromosome segregation protein Spc25, C-terminal [IPR013255]", "Circularly permuted (CP)-type guanine nucleotide-binding (G) domain [IPR030378]", "Class I myosin tail homology domain [IPR010926]", "Class I myosin, motor domain [IPR036072]", "Class II PurE [IPR033626]", "Class II aldolase/adducin N-terminal [IPR001303]", "Class VI myosin, motor domain [IPR036114]", "Classical protein kinase C beta, catalytic domain [IPR034664]", "Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain [IPR003164]", "Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain [IPR008152]", "Clathrin, heavy chain, linker, core motif [IPR015348]", "Clathrin/coatomer adaptor, adaptin-like, N-terminal [IPR002553]", "Cleavage and polyadenylation specificity factor 2, C-terminal [IPR025069]", "Cleavage stimulation factor subunit 1, dimerisation domain [IPR032028]", "Cleavage/polyadenylation specificity factor, A subunit, C-terminal [IPR004871]", "Cleavage/polyadenylation specificity factor, A subunit, N-terminal [IPR018846]", "Clp ATPase, C-terminal [IPR019489]", "Clustered mitochondria protein, N-terminal [IPR028275]", "Cns1/TTC4, wheel domain [IPR044059]", "CoA-binding [IPR003781]", "Coagulation factor 5/8 C-terminal domain [IPR000421]", "Coatomer beta subunit, C-terminal [IPR011710]", "Coatomer beta subunit, appendage platform domain [IPR029446]", "Coatomer subunit gamma, C-terminal [IPR032154]", "Coatomer, WD associated region [IPR006692]", "Coatomer, alpha subunit, C-terminal [IPR010714]", "Coatomer, gamma subunit, appendage, Ig-like subdomain [IPR013040]", "Cobalamin (vitamin B12)-binding domain [IPR006158]", "Cobalamin (vitamin B12)-binding module, cap domain [IPR003759]", "Coilin, N-terminal domain [IPR031722]", "Cold shock domain [IPR011129]", "Cold-shock (CSD) domain [IPR019844]", "Cold-shock protein, DNA-binding [IPR002059]", "Complement Clr-like EGF domain [IPR026823]", "Complex 1 LYR protein domain [IPR008011]", "Condensin complex subunit 1, C-terminal [IPR032682]", "Condensin complex subunit 1, N-terminal [IPR024324]", "Conserved oligomeric Golgi complex, subunit 2, N-terminal [IPR024602]", "Conserved oligomeric Golgi complex, subunit 4 [IPR013167]", "Cop9 signalosome subunit 5 C-terminal domain [IPR040961]", "Copine, C-terminal [IPR010734]", "Copine, C2B domain [IPR037768]", "Core histone macro-H2A, macro domain [IPR035796]", "Cortactin, SH3 domain [IPR035716]", "Creatinase, N-terminal [IPR000587]", "Cro/C1-type helix-turn-helix domain [IPR001387]", "Cullin homology domain [IPR016158]", "Cullin protein, neddylation domain [IPR019559]", "Cullin, N-terminal [IPR001373]", "Cwf19-like protein, C-terminal domain-2 [IPR006767]", "Cwf19-like, C-terminal domain-1 [IPR006768]", "Cyclic nucleotide-binding domain [IPR000595]", "Cyclin, C-terminal domain [IPR004367]", "Cyclin, N-terminal [IPR006671]", "Cyclin-dependent kinase 11/PITSLRE, catalytic domain [IPR045267]", "Cyclin-like [IPR013763]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain [IPR002130]", "Cystatin domain [IPR000010]", "Cysteine-rich flanking region, C-terminal [IPR000483]", "Cystine knot, C-terminal [IPR006207]", "Cytidine and deoxycytidylate deaminase domain [IPR002125]", "Cytochrome C oxidase subunit II, transmembrane domain [IPR011759]", "Cytochrome b-c1 complex subunit Rieske, transmembrane domain [IPR004192]", "Cytochrome b5-like heme/steroid binding domain [IPR001199]", "Cytochrome c oxidase assembly factor 3, mitochondrial, coiled-coil domain [IPR018628]", "Cytochrome c oxidase subunit 2, C-terminal [IPR034210]", "Cytochrome c oxidase subunit II-like C-terminal [IPR002429]", "Cytochrome c oxidase, subunit II [IPR014222]", "Cytoplasmic activation/proliferation-associated protein-1 C term [IPR022070]", "Cytoskeleton-associated protein 2, C-terminal [IPR029197]", "D-3-phosphoglycerate dehydrogenase, ASB domain [IPR045626]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain [IPR006140]", "D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain [IPR006139]", "DALR anticodon binding [IPR008909]", "DAZ-associated protein 1, RNA recognition motif 1 [IPR034134]", "DAZ-associated protein 1, RNA recognition motif 2 [IPR034131]", "DBC1/CARP1 catalytically inactive NUDIX hydrolase domain [IPR025954]", "DBINO domain [IPR020838]", "DBP10, C-terminal [IPR012541]", "DDE superfamily endonuclease domain [IPR004875]", "DDHD domain [IPR004177]", "DDT domain [IPR018501]", "DDX18/Has1, DEAD-box helicase domain [IPR044773]", "DDX41, DEAD-box helicase domain [IPR044113]", "DDX47/Rrp3, DEAD-box helicase domain [IPR044765]", "DDX52/Rok1, DEAD-box helicase domain [IPR044764]", "DEAD box protein 17, ATP-binding domain [IPR046330]", "DEAD/DEAH box helicase domain [IPR011545]", "DEAD2 [IPR010614]", "DEK, C-terminal [IPR014876]", "DET1- and DDB1-associated protein 1, N-terminal [IPR018276]", "DEUBAD domain [IPR044867]", "DExH-box ATP-dependent RNA helicase, R3H domain [IPR034083]", "DFDF domain [IPR025762]", "DHHA1 domain [IPR003156]", "DHX15, DEXH-box helicase domain [IPR044756]", "DHX57, UBA domain [IPR042615]", "DHX8/ Prp22, DEXH-box helicase domain [IPR044762]", "DHX9, DEXH-box helicase domain [IPR044447]", "DHX9, first double-stranded RNA binding domain [IPR044445]", "DHX9, second double-stranded RNA binding domain [IPR044446]", "DJ-1/PfpI [IPR002818]", "DMAP1-binding domain [IPR010506]", "DML1/Misato, tubulin domain [IPR029209]", "DNA (cytosine-5)-methyltransferase 1, replication foci domain [IPR022702]", "DNA damage inducible protein 1 ubiquitin-like domain [IPR033882]", "DNA fragmentation factor 45kDa, middle domain [IPR015121]", "DNA helicase, DnaB-like, C-terminal [IPR007694]", "DNA ligase 3, BRCT domain [IPR031916]", "DNA ligase, ATP-dependent, C-terminal [IPR012309]", "DNA ligase, ATP-dependent, N-terminal [IPR012308]", "DNA ligase, ATP-dependent, central [IPR012310]", "DNA mismatch repair protein MutS, C-terminal [IPR000432]", "DNA mismatch repair protein MutS, clamp [IPR007861]", "DNA mismatch repair protein MutS, connector domain [IPR007860]", "DNA mismatch repair protein MutS, core [IPR007696]", "DNA mismatch repair protein MutS-like, N-terminal [IPR007695]", "DNA polymerase alpha catalytic subunit, N-terminal domain [IPR024647]", "DNA polymerase alpha catalytic subunit, catalytic domain [IPR045846]", "DNA polymerase alpha/delta/epsilon, subunit B [IPR007185]", "DNA polymerase delta subunit 2, C-terminal domain [IPR041863]", "DNA polymerase delta subunit, OB-fold domain [IPR040663]", "DNA polymerase epsilon, catalytic subunit A, C-terminal [IPR013697]", "DNA replication complex GINS protein SLD5, C-terminal [IPR031633]", "DNA replication factor RFC1, C-terminal [IPR013725]", "DNA topoisomerase 2, TOPRIM domain [IPR034157]", "DNA topoisomerase I, DNA binding, eukaryotic-type [IPR008336]", "DNA topoisomerase I, catalytic core, eukaryotic-type [IPR013500]", "DNA topoisomerase I, eukaryotic-type [IPR013499]", "DNA topoisomerase, type IIA, domain A [IPR002205]", "DNA topoisomerase, type IIA, subunit B, domain 2 [IPR013506]", "DNA-dependent protein kinase catalytic subunit, CC3 [IPR012582]", "DNA-dependent protein kinase catalytic subunit, CC5 [IPR045581]", "DNA-dependent protein kinase catalytic subunit, catalytic domain [IPR037706]", "DNA-directed DNA polymerase, family B, exonuclease domain [IPR006133]", "DNA-directed DNA polymerase, family B, multifunctional domain [IPR006134]", "DNA-directed RNA polymerase I subunit RPA2, domain 4 [IPR009674]", "DNA-directed RNA polymerase III subunit RPC1, C-terminal [IPR035698]", "DNA-directed RNA polymerase III subunit RPC1, N-terminal [IPR035697]", "DNA-directed RNA polymerase, N-terminal [IPR029262]", "DNA-directed RNA polymerase, RpoA/D/Rpb3-type [IPR011263]", "DNA-directed RNA polymerase, insert domain [IPR011262]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120]", "DNA-repair protein Xrcc1, N-terminal [IPR002706]", "DNA/RNA non-specific endonuclease [IPR001604]", "DNA/RNA-binding protein Kin17, WH-like domain [IPR019447]", "DNA2/NAM7 helicase, helicase domain [IPR041677]", "DNA2/NAM7 helicase-like, C-terminal [IPR041679]", "DNAJC17, RNA recognition motif [IPR034254]", "DOCKER domain [IPR027357]", "DSBA-like thioredoxin domain [IPR001853]", "DTHCT [IPR012542]", "DWNN domain [IPR014891]", "DZF domain [IPR006561]", "Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791]", "Dbl homology (DH) domain [IPR000219]", "Death domain [IPR000488]", "Dedicator of cytokinesis C, C2 domain [IPR037808]", "Dedicator of cytokinesis C/D, N-terminal [IPR021816]", "Dedicator of cytokinesis, N-terminal domain [IPR032376]", "Dehydrogenase, E1 component [IPR001017]", "Deoxynucleoside kinase domain [IPR031314]", "Desmoplakin, SH3 domain [IPR041615]", "Desmoplakin, spectrin-like domain [IPR041573]", "Deubiquitinating enzyme MINDY-3/4, conserved domain [IPR025257]", "Diacylglycerol kinase, catalytic domain [IPR001206]", "Diacylglycerol/phorbol-ester binding [IPR020454]", "Diaphanous autoregulatory (DAD) domain [IPR014767]", "Dihydrofolate reductase domain [IPR001796]", "Dilute domain [IPR002710]", "Dip2-like domain [IPR037337]", "Dis3-like cold-shock domain 2 [IPR041505]", "Disulphide isomerase [IPR005788]", "DnaJ domain [IPR001623]", "DnaJ homologue subfamily C, GRV2/DNAJC13, N-terminal domain [IPR045802]", "DnaJ-like protein C11, C-terminal [IPR024586]", "Dolichyl-phosphate beta-glucosyltransferase [IPR035518]", "Domain of unknown function DUF1087 [IPR009463]", "Domain of unknown function DUF1115 [IPR010541]", "Domain of unknown function DUF1605 [IPR011709]", "Domain of unknown function DUF1731 [IPR013549]", "Domain of unknown function DUF1747 [IPR013719]", "Domain of unknown function DUF1899 [IPR015048]", "Domain of unknown function DUF3350 [IPR021785]", "Domain of unknown function DUF3385, target of rapamycin protein [IPR024585]", "Domain of unknown function DUF3456 [IPR021852]", "Domain of unknown function DUF3480 [IPR022557]", "Domain of unknown function DUF3517 [IPR021905]", "Domain of unknown function DUF3677 [IPR022145]", "Domain of unknown function DUF3699 [IPR022168]", "Domain of unknown function DUF382 [IPR007180]", "Domain of unknown function DUF4042 [IPR025283]", "Domain of unknown function DUF4149 [IPR025423]", "Domain of unknown function DUF4208 [IPR025260]", "Domain of unknown function DUF4217 [IPR025313]", "Domain of unknown function DUF4749 [IPR031847]", "Domain of unknown function DUF5050 [IPR032485]", "Domain of unknown function DUF5600 [IPR040990]", "Domain of unknown function DUF5604 [IPR040880]", "Domain of unknown function DUF5921 [IPR045803]", "Domain of unknown function DUF625 [IPR006887]", "Double-stranded RNA-binding domain [IPR014720]", "Down-regulated-in-metastasis protein [IPR011430]", "Drebrin-like protein, SH3 domain [IPR035717]", "Dual specificity phosphatase, catalytic domain [IPR000340]", "Dual specificity protein phosphatase domain [IPR020422]", "Dynamin GTPase effector [IPR003130]", "Dynamin stalk domain [IPR000375]", "Dynamin, GTPase domain [IPR001401]", "Dynamin, N-terminal [IPR045063]", "Dynamin-like GTPase OPA1, C-terminal [IPR045817]", "Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]", "Dynein associated protein [IPR022157]", "Dynein heavy chain AAA lid domain [IPR041658]", "Dynein heavy chain region D6 P-loop domain [IPR004273]", "Dynein heavy chain, AAA 5 extension domain [IPR041466]", "Dynein heavy chain, AAA module D4 [IPR024317]", "Dynein heavy chain, ATP-binding dynein motor region [IPR035706]", "Dynein heavy chain, C-terminal domain [IPR041228]", "Dynein heavy chain, coiled coil stalk [IPR024743]", "Dynein heavy chain, hydrolytic ATP-binding dynein motor region [IPR035699]", "Dynein heavy chain, linker [IPR013602]", "Dynein heavy chain, tail [IPR013594]", "Dyskerin-like [IPR012960]", "E1A-binding protein p400, N-terminal [IPR031575]", "E2 binding [IPR014929]", "E3 ligase, CCCH-type zinc finger [IPR041367]", "E3 ubiquitin ligase EDD, ubiquitin-associated domain [IPR024725]", "E3 ubiquitin ligase UBR4, C-terminal [IPR025704]", "E3 ubiquitin ligase, domain of unknown function DUF908 [IPR010309]", "E3 ubiquitin ligase, domain of unknown function DUF913 [IPR010314]", "E3 ubiquitin-protein ligase UBR-like, C-terminal [IPR044046]", "E3 ubiquitin-protein ligase UBR4, N-terminal [IPR045841]", "EB1, C-terminal [IPR004953]", "EBP50, C-terminal [IPR015098]", "EF hand associated, type-1 [IPR013566]", "EF hand associated, type-2 [IPR013567]", "EF-hand domain [IPR002048]", "EF-hand domain, type 1 [IPR015153]", "EF-hand domain, type 2 [IPR015154]", "EF-hand, Ca insensitive [IPR014837]", "EFG, domain V [IPR035649]", "EGF-like calcium-binding domain [IPR001881]", "EGF-like domain [IPR000742]", "EGF-like domain, extracellular [IPR013111]", "EH domain [IPR000261]", "EH domain-containing protein, N-terminal [IPR031692]", "EIF2AK2, first double-stranded RNA binding domain [IPR044452]", "EIF2AK2, second double-stranded RNA binding domain [IPR044453]", "ELM2 domain [IPR000949]", "ELMO domain [IPR006816]", "ELYS, beta-propeller domain [IPR032040]", "ELYS-like domain [IPR025151]", "ENTH domain [IPR013809]", "ER membrane protein complex subunit 1, C-terminal [IPR011678]", "ER membrane protein complex subunit 7, beta-sandwich domain [IPR019008]", "ERAP1-like C-terminal domain [IPR024571]", "ERCC3/RAD25/XPB helicase, C-terminal domain [IPR032438]", "ERCC4 domain [IPR006166]", "ERM family, FERM domain C-lobe [IPR041789]", "ERV/ALR sulfhydryl oxidase domain [IPR017905]", "ERdj5, C-terminal thioredoxin domain [IPR035674]", "ERdj5, first thioredoxin domain [IPR035673]", "ERp29, N-terminal [IPR012883]", "EWS, RNA recognition motif [IPR034869]", "EXPERA domain [IPR033118]", "Electron transfer flavoprotein, alpha subunit, C-terminal [IPR014731]", "Electron transfer flavoprotein, alpha subunit, N-terminal [IPR033947]", "Electron transfer flavoprotein, alpha/beta-subunit, N-terminal [IPR014730]", "Electron transfer flavoprotein, beta subunit, N-terminal [IPR033948]", "Elongation Factor G, domain II [IPR041095]", "Elongation factor 1 beta central acidic region, eukaryote [IPR018940]", "Elongation factor 1B gamma, C-terminal [IPR001662]", "Elongation factor EFG, domain V-like [IPR000640]", "Elongation factor G, domain III [IPR009022]", "Elongation factor Tu (EF-Tu), GTP-binding domain [IPR041709]", "Elongation factor Tu, domain 2 [IPR033720]", "Elp3/MiaB/NifB [IPR006638]", "Emerin, LEM domain [IPR034989]", "Endonuclease/exonuclease/phosphatase [IPR005135]", "Endophilin B2, SH3 domain [IPR035640]", "Endophilin-A, SH3 domain [IPR035824]", "Endophilin-B1, BAR domain [IPR035695]", "Endoplasmic reticulum resident protein 29, C-terminal [IPR011679]", "Endoplasmic reticulum resident protein 44, TRX-like domain b [IPR041870]", "Endoplasmic reticulum resident protein 44, TRX-like domain b' [IPR041862]", "Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]", "Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]", "Enhancer of mRNA-decapping protein 4, WD40 repeat region [IPR032401]", "Enhancer of polycomb-like, N-terminal [IPR019542]", "Enolase, C-terminal TIM barrel domain [IPR020810]", "Enolase, N-terminal [IPR020811]", "Enoyl-CoA hydratase/isomerase domain [IPR045004]", "Era-type guanine nucleotide-binding (G) domain [IPR030388]", "Eukaryotic Ribosomal Protein L27, KOW domain [IPR041991]", "Eukaryotic glycogen debranching enzyme, N-terminal domain [IPR029436]", "Eukaryotic translation initiation factor 3 subunit E, N-terminal [IPR019010]", "Eukaryotic translation initiation factor 3 subunit G, N-terminal [IPR024675]", "Exonuclease 1-like, PIN-like domain [IPR044752]", "Exonuclease, RNase T/DNA polymerase III [IPR013520]", "Exonuclease-1, H3TH domain [IPR037315]", "Exoribonuclease Xrn1, D2/D3 domain [IPR041106]", "Exoribonuclease, phosphorolytic domain 1 [IPR001247]", "Exoribonuclease, phosphorolytic domain 2 [IPR015847]", "Exosome complex component CSL4, C-terminal [IPR019495]", "Exosome complex component, N-terminal domain [IPR025721]", "Exosome complex exonuclease RRP44, S1 domain [IPR033770]", "Exosome-associated factor Rrp6, N-terminal [IPR012588]", "Exportin-1, C-terminal [IPR014877]", "Exportin-1/Importin-beta-like [IPR013598]", "Exportin-2, C-terminal [IPR005043]", "Exportin-2, central domain [IPR013713]", "Exportin-5, C-terminal domain [IPR045478]", "Exportin-T, C-terminal domain [IPR045546]", "Extended PHD (ePHD) domain [IPR034732]", "Extended synaptotagmin, C-terminal C2 domain [IPR037752]", "Extended synaptotagmin, C2A domain [IPR037733]", "Extended synaptotagmin, C2B domain [IPR037749]", "Extracellular Endonuclease, subunit A [IPR020821]", "F-BAR domain [IPR031160]", "F-box domain [IPR001810]", "FACT complex subunit POB3-like, N-terminal PH domain [IPR035417]", "FACT complex subunit Spt16 domain [IPR013953]", "FACT complex subunit Spt16, N-terminal lobe domain [IPR029148]", "FACT complex subunit Spt16, peptidase M24-like domain [IPR033825]", "FAD dependent oxidoreductase [IPR006076]", "FAD dependent oxidoreductase, central domain [IPR032503]", "FAD linked oxidase, N-terminal [IPR006094]", "FAD-binding domain, PCMH-type [IPR016166]", "FAD-binding domain, ferredoxin reductase-type [IPR017927]", "FAD-dependent oxidoreductase 2, FAD binding domain [IPR003953]", "FAD-linked oxidase, C-terminal [IPR004113]", "FAD/NAD(P)-binding domain [IPR023753]", "FAF1, UBA-like domain [IPR044541]", "FANCI helical domain 1 [IPR029310]", "FANCI helical domain 2 [IPR029312]", "FANCI solenoid 1 cap [IPR029305]", "FANCI solenoid 1 domain [IPR029308]", "FANCI solenoid 2 domain [IPR029315]", "FANCI solenoid 3 domain [IPR029313]", "FANCI solenoid 4 domain [IPR029314]", "FARP1/FARP2/FRMD7, FERM domain C-lobe [IPR041788]", "FAS-associated factor 1-like, UBX domain [IPR033043]", "FAST kinase leucine-rich [IPR010622]", "FAST kinase-like protein, subdomain 2 [IPR013579]", "FATC domain [IPR003152]", "FCH domain [IPR001060]", "FCP1 homology domain [IPR004274]", "FDF domain [IPR019050]", "FERM adjacent (FA) [IPR014847]", "FERM central domain [IPR019748]", "FERM domain [IPR000299]", "FERM, C-terminal PH-like domain [IPR018980]", "FERM, N-terminal [IPR018979]", "FF domain [IPR002713]", "FFD box [IPR025761]", "FGFR1 oncogene partner (FOP), N-terminal dimerisation domain [IPR018993]", "FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]", "FKBP12-rapamycin binding domain [IPR009076]", "FKBP3, basic tilted helix bundle domain [IPR041200]", "FMP27, C-terminal [IPR019443]", "FMP27, GFWDK domain [IPR019441]", "FMP27, N-terminal [IPR019439]", "FY-rich, C-terminal [IPR003889]", "FY-rich, N-terminal [IPR003888]", "FYVE zinc finger [IPR000306]", "Far upstream element-binding protein, C-terminal [IPR015096]", "Fascin domain [IPR022768]", "Fatty acid hydroxylase [IPR006694]", "Fatty acyl-CoA reductase, C-terminal [IPR033640]", "Fatty acyl-coenzyme A reductase, NAD-binding domain [IPR013120]", "Fcf2 pre-rRNA processing, C-terminal [IPR014810]", "Ferrochelatase, C-terminal [IPR033644]", "Ferrochelatase, N-terminal [IPR033659]", "Fibronectin type II domain [IPR000562]", "Fibronectin type III [IPR003961]", "First polo-box domain [IPR033701]", "Flavodoxin-like [IPR001094]", "Flavodoxin/nitric oxide synthase [IPR008254]", "Flavoprotein pyridine nucleotide cytochrome reductase [IPR001709]", "Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain [IPR008333]", "Follistatin-like, N-terminal [IPR003645]", "Forkhead-associated (FHA) domain [IPR000253]", "Formin, FH2 domain [IPR015425]", "Formin, FH3 domain [IPR010472]", "Formin, GTPase-binding domain [IPR010473]", "Formyl transferase, N-terminal [IPR002376]", "Fragile X-related 1 protein, C-terminal core [IPR022034]", "Fragile X-related 1 protein, C-terminal region 1 [IPR032172]", "Fragile X-related 1 protein, C-terminal region 3 [IPR032177]", "Fragile X-related mental retardation protein, C-terminal region 2 [IPR032196]", "Fumarase C, C-terminal [IPR018951]", "Fumarate lyase, N-terminal [IPR022761]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal [IPR015939]", "Fumarylacetoacetase, N-terminal [IPR015377]", "Fumarylacetoacetase-like, C-terminal [IPR011234]", "Furin-like cysteine-rich domain [IPR006211]", "Fxr1, tudor domain [IPR041560]", "Fzo/mitofusin HR2 domain [IPR006884]", "G-patch domain [IPR000467]", "G-protein gamma-like domain [IPR015898]", "G-protein, beta subunit [IPR001632]", "G3BP1, RNA recognition motif [IPR034374]", "G3BP2, RNA recognition motif [IPR034376]", "GAD domain [IPR029351]", "GAR domain [IPR003108]", "GAT domain [IPR004152]", "GCC2, Rab binding domain [IPR032023]", "GCF, C-terminal [IPR022783]", "GDAP2, macro domain [IPR035793]", "GHMP kinase N-terminal domain [IPR006204]", "GHMP kinase, C-terminal domain [IPR013750]", "GINS complex protein Sld5, alpha-helical domain [IPR038749]", "GINS subunit, domain A [IPR021151]", "GMP phosphodiesterase, delta subunit [IPR008015]", "GMP synthase, C-terminal [IPR001674]", "GMP synthase, glutamine amidotransferase [IPR004739]", "GMP synthetase ATP pyrophosphatase domain [IPR025777]", "GNAT domain [IPR000182]", "GOLD domain [IPR009038]", "GPAT/DHAPAT, acyltransferase domain [IPR041728]", "GPR domain [IPR000965]", "GRAM domain [IPR004182]", "GRASP-type PDZ domain [IPR024958]", "GRB2, C-terminal SH3 domain [IPR035643]", "GRB2, N-terminal SH3 domain [IPR035641]", "GRIP domain [IPR000237]", "GRSF-1, RNA recognition motif 1 [IPR034425]", "GRSF-1, RNA recognition motif 2 [IPR034424]", "GRSF-1, RNA recognition motif 3 [IPR034426]", "GTP binding domain [IPR006073]", "GTP binding protein 1-like, GTP-binding domain [IPR035531]", "GTP binding protein, second domain [IPR031662]", "GTP-binding protein TrmE, N-terminal [IPR018948]", "GTP1/OBG domain [IPR006169]", "GTPase effector domain [IPR020850]", "GUCT [IPR012562]", "GYF domain 2 [IPR025640]", "GYF domain [IPR003169]", "Galactokinase, N-terminal domain [IPR019539]", "Galactose mutarotase, N-terminal barrel [IPR031727]", "Galectin, carbohydrate recognition domain [IPR001079]", "Gamma tubulin complex component protein, N-terminal [IPR041470]", "Gamma tubulin complex component, C-terminal [IPR040457]", "Gamma-adaptin ear (GAE) domain [IPR008153]", "Gamma-glutamyl cyclotransferase-like [IPR013024]", "Gasdermin, PUB domain [IPR041263]", "Gasdermin, pore forming domain [IPR040460]", "Gcp-like domain [IPR000905]", "Gelsolin-like domain [IPR007123]", "Gfo/Idh/MocA-like oxidoreductase, N-terminal [IPR000683]", "GlmS/AgaS, SIS domain 1 [IPR035466]", "GlmS/FrlB, SIS domain 2 [IPR035490]", "Glucosamine/galactosamine-6-phosphate isomerase [IPR006148]", "Glucose-6-phosphate dehydrogenase, C-terminal [IPR022675]", "Glucose-6-phosphate dehydrogenase, NAD-binding [IPR022674]", "Glucosidase 2 subunit beta-like [IPR036607]", "Glucosidase II beta subunit, N-terminal [IPR028146]", "Glucosyltransferase 24, catalytic domain [IPR040497]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal [IPR006096]", "Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain [IPR006097]", "Glutaminase, EF-hand domain [IPR041541]", "Glutamine amidotransferase [IPR017926]", "Glutamine amidotransferase type 2 domain [IPR017932]", "Glutamine-Leucine-Glutamine, QLQ [IPR014978]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2 [IPR007638]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal [IPR007639]", "Glutamyl-tRNA synthetase [IPR033910]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain [IPR020059]", "Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain [IPR020058]", "Glutaredoxin [IPR002109]", "Glutaredoxin subgroup [IPR014025]", "Glutaredoxin, PICOT-like [IPR033658]", "Glutaredoxin, eukaryotic/virial [IPR011899]", "Glutathione S-transferase, C-terminal [IPR004046]", "Glutathione S-transferase, C-terminal-like [IPR010987]", "Glutathione S-transferase, N-terminal [IPR004045]", "Glutathione synthase, substrate-binding domain [IPR004887]", "Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain [IPR020828]", "Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain [IPR020829]", "Glycerol-3-phosphate acyltransferase-like, C-terminal domain [IPR045520]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal [IPR006109]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal [IPR011128]", "Glycerophosphodiester phosphodiesterase domain [IPR030395]", "Glycine cleavage T-protein, C-terminal barrel domain [IPR013977]", "Glycogen debranching enzyme, C-terminal [IPR032790]", "Glycogen debranching enzyme, central domain [IPR032788]", "Glycogen debranching enzyme, glucanotransferase domain [IPR032792]", "Glycoside hydrolase 35, catalytic domain [IPR031330]", "Glycoside hydrolase family 18, catalytic domain [IPR001223]", "Glycoside hydrolase family 2, catalytic domain [IPR006103]", "Glycoside hydrolase family 20, catalytic domain [IPR015883]", "Glycoside hydrolase family 31, N-terminal domain [IPR025887]", "Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich [IPR006102]", "Glycosyl hydrolase family 30, TIM-barrel domain [IPR033453]", "Glycosyl hydrolase family 30, beta sandwich domain [IPR033452]", "Glycosyl hydrolase family 63, C-terminal [IPR031335]", "Glycosyl hydrolase family 63, N-terminal [IPR031631]", "Glycosyl hydrolase, family 13, catalytic domain [IPR006047]", "Glycosyl hydrolases family 2, sugar binding domain [IPR006104]", "Glycosyl transferase CAP10 domain [IPR006598]", "Glycosyl transferase, family 1 [IPR001296]", "Glycosyltransferase 2-like [IPR001173]", "Glycyl-tRNA synthetase-like core domain [IPR033731]", "Glyoxalase domain-containing protein 4, C-terminal [IPR043194]", "Glyoxalase/fosfomycin resistance/dioxygenase domain [IPR004360]", "Growth hormone-inducible transmembrane protein [IPR035871]", "Guanine nucleotide exchange factor, N-terminal [IPR032691]", "Guanine nucleotide-binding protein-like 3, N-terminal domain [IPR014813]", "Guanylate kinase-like domain [IPR008144]", "Guanylate kinase/L-type calcium channel beta subunit [IPR008145]", "HAD-superfamily hydrolase, subfamily IIID [IPR011943]", "HBS1-like protein, N-terminal [IPR015033]", "HD domain [IPR006674]", "HD/PDEase domain [IPR003607]", "HDGF-related, PWWP domain [IPR035496]", "HECT domain [IPR000569]", "HELLS, N-terminal [IPR044753]", "HELP [IPR005108]", "HHH domain 9 [IPR041692]", "HIRAN domain [IPR014905]", "HIT-like domain [IPR011146]", "HORMA domain [IPR003511]", "HR1 rho-binding domain [IPR011072]", "HRDC domain [IPR002121]", "HSPA4, nucleotide-binding domain [IPR042052]", "HSPA4L, nucleotide-binding domain [IPR042708]", "HSPH1, nucleotide-binding domain [IPR042053]", "HTH CenpB-type DNA-binding domain [IPR006600]", "HTTM [IPR011020]", "HUWE1, UBA domain [IPR041918]", "Heat shock 70kDa protein 14, nucleotide-binding domain [IPR042049]", "Heat shock chaperonin-binding [IPR006636]", "Heat shock protein DnaJ, cysteine-rich domain [IPR001305]", "Heat shock protein Hsp90, N-terminal [IPR020575]", "Heat shock protein beta-1, ACD domain [IPR037876]", "Helical and beta-bridge domain [IPR010643]", "Helicase XPB/Ssl2, N-terminal domain [IPR032830]", "Helicase domain [IPR007807]", "Helicase superfamily 1/2, ATP-binding domain [IPR014001]", "Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type [IPR014013]", "Helicase, C-terminal [IPR001650]", "Helicase-associated domain [IPR007502]", "Helicase-like, DEXD box c2 type [IPR006554]", "Helicase/SANT-associated domain [IPR014012]", "Helicase/UvrB, N-terminal [IPR006935]", "Helix-hairpin-helix DNA-binding motif, class 1 [IPR003583]", "Helix-turn-helix DNA-binding domain of Spt6 [IPR028088]", "Hemimethylated DNA-binding domain [IPR011722]", "Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain [IPR024641]", "Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 1 [IPR034544]", "Heterogeneous nuclear ribonucleoprotein Q, RNA recognition motif 2 [IPR034548]", "Heterogeneous nuclear ribonucleoprotein R, RNA recognition motif 2 [IPR034411]", "Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]", "Hexokinase, C-terminal [IPR022673]", "Hexokinase, N-terminal [IPR022672]", "High mobility group box domain 5 [IPR029215]", "High mobility group box domain [IPR009071]", "Histidine kinase domain [IPR005467]", "Histidine kinase/HSP90-like ATPase [IPR003594]", "Histone H2A, C-terminal domain [IPR032454]", "Histone H2A/H2B/H3 [IPR007125]", "Histone acetyl transferase HAT1 N-terminal [IPR019467]", "Histone acetyltransferase domain, MYST-type [IPR002717]", "Histone chaperone domain CHZ [IPR019098]", "Histone deacetylase domain [IPR023801]", "Histone deacetylase interacting domain [IPR013194]", "Histone methyltransferase, Tudor domain 1 [IPR041291]", "Histone methyltransferase, Tudor domain 2 [IPR041292]", "Histone-arginine methyltransferase CARM1, N-terminal [IPR020989]", "Histone-binding protein RBBP4, N-terminal [IPR022052]", "HnRNP M, nuclear localisation signal [IPR024666]", "Homeobox domain [IPR001356]", "Homocysteine-binding domain [IPR003726]", "Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120]", "HuR, RNA recognition motif 2 [IPR034996]", "Hyaluronan/mRNA-binding protein [IPR006861]", "Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain [IPR013746]", "Hydroxymethylglutaryl-coenzyme A synthase, N-terminal [IPR013528]", "I/LWEQ domain [IPR002558]", "IBR domain [IPR002867]", "IF2a, S1-like domain [IPR044126]", "IGF2BP1, RNA recognition motif 1 [IPR034837]", "IGF2BP1, RNA recognition motif 2 [IPR034842]", "IGF2BP2, RNA recognition motif 1 [IPR034843]", "IGF2BP3, RNA recognition motif 2 [IPR034844]", "IMD/I-BAR domain [IPR013606]", "IMP dehydrogenase/GMP reductase [IPR001093]", "IQ motif and SEC7 domain-containing protein, PH domain [IPR033742]", "IRS-type PTB domain [IPR002404]", "IRSp53, SH3 domain [IPR035594]", "ISWI, HAND domain [IPR015194]", "Ima1, N-terminal domain [IPR018617]", "Immunoglobulin C1-set [IPR003597]", "Immunoglobulin I-set [IPR013098]", "Immunoglobulin V-set domain [IPR013106]", "Immunoglobulin subtype 2 [IPR003598]", "Immunoglobulin subtype [IPR003599]", "Immunoglobulin-like domain [IPR007110]", "Importin-alpha, importin-beta-binding domain [IPR002652]", "Importin-beta, N-terminal domain [IPR001494]", "Initiation factor eIF-4 gamma, MA3 [IPR003891]", "Inner centromere protein, ARK-binding domain [IPR005635]", "Inositol 1,3,4-trisphosphate 5/6-kinase, ATP-grasp domain [IPR040464]", "Inositol polyphosphate 5-phosphatase, clathrin binding domain [IPR031995]", "Inositol polyphosphate-related phosphatase [IPR000300]", "Inositol-tetrakisphosphate 1-kinase, N-terminal [IPR041429]", "Integrator complex subunit 14, C-terminal [IPR045814]", "Integrator complex subunit 3, N-terminal [IPR019333]", "Integrin beta N-terminal [IPR033760]", "Integrin beta subunit, VWA domain [IPR002369]", "Integrin beta subunit, cytoplasmic domain [IPR014836]", "Integrin beta subunit, tail [IPR012896]", "Integrin beta, epidermal growth factor-like domain 1 [IPR040622]", "Interferon gamma receptor, poxvirus/mammal [IPR021126]", "Interferon regulatory factor 2-binding protein 1 & 2, zinc finger [IPR022750]", "Intermediate filament head, DNA-binding domain [IPR006821]", "Intermediate filament, rod domain [IPR039008]", "Intracellular hyaluronan-binding protein 4, N-terminal domain [IPR032381]", "Intron-binding protein aquarius, N-terminal [IPR032174]", "Ion transporter-like, CBS domain [IPR044751]", "Iron sulphur domain-containing, mitoNEET, N-terminal [IPR019610]", "Iron-binding zinc finger, CDGSH type [IPR018967]", "Isochorismatase-like [IPR000868]", "Isoleucyl tRNA synthetase type 1, anticodon-binding domain [IPR033708]", "Isoleucyl tRNA synthetase type 2, anticodon-binding domain [IPR033709]", "Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain [IPR044861]", "Isopropylmalate dehydrogenase-like domain [IPR024084]", "JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]", "JNK-interacting protein, leucine zipper II [IPR032486]", "JNK/Rab-associated protein-1, N-terminal [IPR019143]", "JmjC domain [IPR003347]", "JmjN domain [IPR003349]", "Jumonji, helical domain [IPR041070]", "K Homology domain [IPR004087]", "K Homology domain, type 1 [IPR004088]", "K Homology domain, type 2 [IPR004044]", "KASH domain [IPR012315]", "KHDRBS, Qua1 domain [IPR032571]", "KMT2A, PHD domain 1 [IPR042023]", "KMT2A, PHD domain 2 [IPR042025]", "KMT2A, PHD domain 3 [IPR044133]", "KMT2A, ePHD domain [IPR041958]", "KN17, SH3-like C-terminal domain [IPR041330]", "KOW [IPR005824]", "Kin17, KOW domain [IPR041995]", "Kindlin-2, N-terminal [IPR040790]", "Kindlin/fermitin, PH domain [IPR037837]", "Kinesin motor domain [IPR001752]", "Kinesin-associated [IPR032405]", "Kinesin-associated microtubule-binding domain [IPR025901]", "Kinesin-like KIF1-type [IPR022140]", "Kinesin-like [IPR022164]", "Kinesin-like protein Kif23, Arf6-interacting domain [IPR032384]", "Kinetochore protein Cenp-F/LEK1, Rb protein-binding domain [IPR018302]", "Kinetochore protein Nuf2, N-terminal [IPR005549]", "Kri1-like, C-terminal [IPR024626]", "Krr1, KH1 domain [IPR041174]", "Ku, C-terminal [IPR014893]", "Ku70/Ku80 C-terminal arm [IPR005160]", "Ku70/Ku80 beta-barrel domain [IPR006164]", "Ku70/Ku80, N-terminal alpha/beta [IPR005161]", "L27 domain [IPR004172]", "L27 domain, C-terminal [IPR014775]", "LAIKA domain [IPR045353]", "LARP4, RNA recognition motif [IPR034903]", "LARP5, RNA recognition motif [IPR034900]", "LARP7, RNA recognition motif 1 [IPR034887]", "LARP7, RNA recognition motif 2 [IPR034910]", "LEM domain [IPR003887]", "LEM-like domain [IPR013146]", "LETM1, ribosome-binding domain [IPR033122]", "LETM1-like [IPR011685]", "LIS1 homology motif [IPR006594]", "LSM domain, eukaryotic/archaea-type [IPR001163]", "LSM-interacting domain [IPR008669]", "La protein, xRRM domain [IPR014886]", "La-related protein 7, La domain [IPR034946]", "La-type HTH domain [IPR006630]", "Lactate/malate dehydrogenase, C-terminal [IPR022383]", "Lactate/malate dehydrogenase, N-terminal [IPR001236]", "Lamin tail domain [IPR001322]", "Lamin-B receptor of TUDOR domain [IPR019023]", "Lamina-associated polypeptide 2 alpha, C-terminal [IPR021623]", "Laminin G domain [IPR001791]", "Large proline-rich protein BAG6 [IPR021925]", "Lariat debranching enzyme, C-terminal [IPR007708]", "Lariat debranching enzyme, N-terminal metallophosphatase domain [IPR041816]", "Lasp1, SH3 domain [IPR035630]", "Legume-like lectin [IPR005052]", "Lens epithelium-derived growth factor, integrase-binding domain [IPR021567]", "Lethal giant larvae homologue 2 [IPR013577]", "Leucine zipper, homeobox-associated [IPR003106]", "Leucine-rich repeat N-terminal domain [IPR000372]", "Leukocyte surface antigen CD47, IgV [IPR037805]", "Linker histone H1/H5, domain H15 [IPR005818]", "Lon, substrate-binding domain [IPR003111]", "Longin domain [IPR010908]", "Lsm14-like, N-terminal [IPR025609]", "LsmAD domain [IPR009604]", "Lysine-specific demethylase-like domain [IPR013637]", "Lysine-tRNA ligase, class II, N-terminal [IPR044136]", "Lysophosphatidylcholine acyltransferase LPCAT1-like [IPR045252]", "Lysyl-tRNA synthetase, class II, C-terminal [IPR018149]", "M60-like domain, N-terminal [IPR035423]", "MAGE homology domain [IPR002190]", "MAN1, RNA recognition motif [IPR034394]", "MANSC domain [IPR013980]", "MATH/TRAF domain [IPR002083]", "MCM N-terminal domain [IPR027925]", "MCM OB domain [IPR033762]", "MCM domain [IPR001208]", "MCM, AAA-lid domain [IPR041562]", "MD-2-related lipid-recognition domain [IPR003172]", "MDM2-binding protein, N-terminal domain [IPR029421]", "MDM2-binding protein, central domain [IPR029420]", "MDN2-binding protein, C-terminal domain [IPR029418]", "MEF-2, RNA recognition motif 1 [IPR034630]", "MEF-2, RNA recognition motif 3 [IPR034631]", "MENTAL domain [IPR019498]", "MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]", "MHC class I, alpha chain, C-terminal [IPR010579]", "MHC class I-like antigen recognition-like [IPR011161]", "MIA2, SH3 domain [IPR035555]", "MIF4G-like, type 1 [IPR015172]", "MIF4G-like, type 2 [IPR015174]", "MIF4G-like, type 3 [IPR003890]", "MIRO domain [IPR020860]", "MIT domain [IPR007330]", "MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding [IPR021043]", "MMS19, C-terminal [IPR024687]", "MMS19, N-terminal [IPR029240]", "MOSC, N-terminal beta barrel [IPR005303]", "MPN domain [IPR037518]", "MPP2, SH3 domain [IPR035602]", "MPP6, SH3 domain [IPR035603]", "MPP7, SH3 domain [IPR035599]", "MRG domain [IPR026541]", "MRH domain [IPR044865]", "MRPL44, double-stranded RNA binding domain [IPR044444]", "MTMR6, PH-GRAM domain [IPR035998]", "MYST, zinc finger domain [IPR040706]", "Macro domain [IPR002589]", "Mad3/Bub1 homology region 1 [IPR013212]", "Major facilitator superfamily domain [IPR020846]", "Major sperm protein (MSP) domain [IPR000535]", "Malectin domain [IPR021720]", "Malic enzyme, N-terminal domain [IPR012301]", "Malic enzyme, NAD-binding [IPR012302]", "Man1/Src1, C-terminal [IPR018996]", "Manganese/iron superoxide dismutase, C-terminal [IPR019832]", "Manganese/iron superoxide dismutase, N-terminal [IPR019831]", "Mannosidase Ig/CBM-like domain [IPR041447]", "MaoC-like dehydratase domain [IPR002539]", "Marvel domain [IPR008253]", "Matrin-3, RNA recognition motif 1 [IPR034928]", "Matrin-3, RNA recognition motif 2 [IPR034930]", "Matrin/U1-C, C2H2-type zinc finger [IPR000690]", "Matrin/U1-C-like, C2H2-type zinc finger [IPR003604]", "Mcm6, C-terminal winged-helix domain [IPR041024]", "Membrane insertase YidC/Oxa1, C-terminal [IPR028055]", "Metallo-beta-lactamase [IPR001279]", "Metastasis-associated protein MTA1, R1 domain [IPR035170]", "Metaxin, glutathione S-transferase domain [IPR033468]", "Methionine synthase, B12-binding domain [IPR033706]", "Methionine--tRNA ligase, N-terminal [IPR041598]", "Methioninyl-tRNA synthetase core domain [IPR033911]", "Methionyl-tRNA synthetase, anticodon-binding domain [IPR041872]", "Methionyl/Leucyl tRNA synthetase [IPR015413]", "Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding [IPR013155]", "Methyl-CpG DNA binding [IPR001739]", "Methyl-CpG binding protein 2/3, C-terminal domain [IPR025884]", "Methyl-CpG-binding domain protein 2/3, p55-binding region [IPR032343]", "Methylglyoxal synthase-like domain [IPR011607]", "Methylmalonyl-CoA mutase, C-terminal [IPR006159]", "Methylmalonyl-CoA mutase, alpha chain, catalytic [IPR006098]", "Methylmalonyl-CoA mutase, alpha/beta chain, catalytic [IPR006099]", "Methylthiotransferase, N-terminal [IPR013848]", "Methyltransferase domain 25 [IPR041698]", "Methyltransferase type 11 [IPR013216]", "Methyltransferase type 12 [IPR013217]", "Mff-like domain [IPR039433]", "Mib-herc2 [IPR010606]", "Micro-fibrillar-associated protein 1, C-terminal [IPR009730]", "Midasin AAA lid domain 5 [IPR041190]", "Midasin, AAA lid domain 7 [IPR040848]", "Midline-1, COS domain [IPR040859]", "Minichromosome loss protein Mcl1, middle region [IPR022100]", "Misato Segment II tubulin-like domain [IPR019605]", "Mitochondrial apoptosis-inducing factor, C-terminal domain [IPR029324]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs [IPR034884]", "Mitochondrial degradasome RNA helicase subunit, C-terminal domain [IPR022192]", "Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564]", "MnmE, helical domain [IPR025867]", "MoaB/Mog domain [IPR001453]", "MoeA, C-terminal, domain IV [IPR005111]", "MoeA, N-terminal and linker domain [IPR005110]", "Molybdenum cofactor sulfurase, C-terminal [IPR005302]", "Molybdopterin oxidoreductase [IPR006656]", "Molybdopterin oxidoreductase, 4Fe-4S domain [IPR006963]", "Morc, S5 domain 2-like [IPR041006]", "Mre11 nuclease, N-terminal metallophosphatase domain [IPR041796]", "Mre11, DNA-binding [IPR007281]", "Mu homology domain [IPR028565]", "Mu2, C-terminal domain [IPR043512]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal [IPR031717]", "Multiple myeloma tumor-associated protein 2-like, N-terminal [IPR019315]", "Multiprotein bridging factor 1, N-terminal [IPR013729]", "Myb domain [IPR017930]", "Myo-inositol-1-phosphate synthase, GAPDH-like [IPR013021]", "Myosin VI, cargo binding domain [IPR032412]", "Myosin head, motor domain [IPR001609]", "Myosin phosphatase-RhoA interacting protein, PH domain [IPR039597]", "Myosin tail [IPR002928]", "Myosin, N-terminal, SH3-like [IPR004009]", "Myotubularin-like phosphatase domain [IPR010569]", "Myristoyl-CoA:protein N-myristoyltransferase, C-terminal [IPR022677]", "Myristoyl-CoA:protein N-myristoyltransferase, N-terminal [IPR022676]", "N-acetylgalactosaminyltransferase [IPR045885]", "N-acetylneuraminic acid synthase, N-terminal [IPR013132]", "N-terminal extension of GAT domain [IPR041198]", "NAD(P) binding domain of glutamate dehydrogenase [IPR033922]", "NAD(P) transhydrogenase, alpha subunit, C-terminal [IPR024605]", "NAD(P)-binding domain [IPR016040]", "NAD-dependent epimerase/dehydratase [IPR001509]", "NAD/GMP synthase [IPR022310]", "NADH pyrophosphatase-like, N-terminal [IPR015375]", "NADH-quinone oxidoreductase, chain G, C-terminal [IPR015405]", "NADH-quinone oxidoreductase, subunit D [IPR001135]", "NADH:ubiquinone oxidoreductase intermediate-associated protein 30 [IPR013857]", "NADH:ubiquinone oxidoreductase, 30kDa subunit [IPR001268]", "NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding [IPR019574]", "NADH:ubiquinone oxidoreductase-like, 20kDa subunit [IPR006137]", "NADP transhydrogenase beta-like domain [IPR034300]", "NADP-dependent oxidoreductase domain [IPR023210]", "NDUFB9, LYR domain [IPR045292]", "NECAP, PHear domain [IPR012466]", "NEDD8 ultimate buster 1, ubiquitin-like domain [IPR041207]", "NET domain [IPR027353]", "NF-kappaB-repression factor, R3H domain [IPR034071]", "NGN domain [IPR005100]", "NGN domain, eukaryotic [IPR039385]", "NHL2, NHL repeat domain [IPR045302]", "NIPSNAP [IPR012577]", "NLE [IPR012972]", "NOG, C-terminal [IPR012973]", "NOG1, N-terminal helical domain [IPR041623]", "NOP5, N-terminal [IPR012974]", "NOPS [IPR012975]", "NOSIC [IPR012976]", "NP60, PWWP domain [IPR035501]", "NPL4, zinc-binding putative [IPR007716]", "NSD, Cys-His rich domain [IPR041306]", "NUC153 [IPR012580]", "NUC205 domain [IPR012584]", "NUDIX hydrolase [IPR020476]", "NUDIX hydrolase domain [IPR000086]", "NVL2, nucleolin binding domain [IPR031996]", "Nascent polypeptide-associated complex NAC domain [IPR002715]", "Negative elongation factor E, RNA recognition motif [IPR034637]", "Neurobeachin-like, DUF1088 [IPR010508]", "Neurobeachin/BDCP, DUF4704 [IPR031570]", "Neuroblastoma-amplified sequence, N-terminal [IPR029145]", "Nicastrin, small lobe [IPR041084]", "Nicotinamide phosphoribosyltransferase, N-terminal domain [IPR041529]", "Nicotinate/nicotinamide phosphoribosyltransferase [IPR041525]", "Niemann-Pick C1, N-terminal [IPR032190]", "Nin one binding (NOB1) Zn-ribbon-like [IPR014881]", "Nit1/2, carbon-nitrogen hydrolase domain [IPR045254]", "Nitric oxide synthase-interacting protein, zinc-finger [IPR031790]", "Non-canonical purine NTP phosphatase/PRRC1 [IPR026533]", "Nop domain [IPR002687]", "Nop2p [IPR011023]", "Npc2 like, ML domain [IPR033916]", "Nrap protein domain 1 [IPR035082]", "Nrap protein, domain 2 [IPR035367]", "Nrap protein, domain 3 [IPR035368]", "Nrap protein, domain 4 [IPR035369]", "Nrap protein, domain 5 [IPR035370]", "Nrap protein, domain 6 [IPR035371]", "Nuclear RNA export factor Tap, RNA-binding domain [IPR015245]", "Nuclear condensin complex subunit 3, C-terminal domain [IPR025977]", "Nuclear migration protein nudC [IPR032572]", "Nuclear pore complex protein Nup214, phenylalanine-glycine (FG) domain [IPR041553]", "Nuclear pore complex, NUP2/50/61 [IPR015007]", "Nuclear pore localisation protein NPL4, C-terminal [IPR007717]", "Nuclear pore localisation protein Npl4, ubiquitin-like domain [IPR024682]", "Nuclear protein 96 [IPR021967]", "Nuclear transport factor 2 domain [IPR002075]", "Nuclear transport factor 2, eukaryote [IPR018222]", "Nuclear-interacting partner of ALK/Rsm1-like [IPR013909]", "Nucleolar 27S pre-rRNA processing, Urb2/Npa2, C-terminal [IPR018849]", "Nucleolar GTP-binding protein 1, Rossman-fold domain [IPR010674]", "Nucleolar GTP-binding protein 2, N-terminal domain [IPR012971]", "Nucleolar complex-associated protein 3, N-terminal [IPR011501]", "Nucleolar pre-ribosomal-associated protein 1, C-terminal domain [IPR032436]", "Nucleolar pre-ribosomal-associated protein 1, N-terminal [IPR021714]", "Nucleolar protein 7, C-terminal [IPR012579]", "Nucleolar protein 8, RNA recognition motif [IPR034138]", "Nucleolin, RNA recognition motif 1 [IPR034230]", "Nucleolin, RNA recognition motif 2 [IPR034233]", "Nucleolin, RNA recognition motif 3 [IPR034234]", "Nucleolin, RNA recognition motif 4 [IPR034235]", "Nucleophosmin, C-terminal [IPR032569]", "Nucleoplasmin core domain [IPR024057]", "Nucleoporin Nup153, N-terminal [IPR013913]", "Nucleoporin Nup188, N-terminal [IPR018864]", "Nucleoporin Nup54, alpha-helical domain [IPR025712]", "Nucleoporin, NSP1-like, C-terminal [IPR007758]", "Nucleoporin, Nup133/Nup155-like, C-terminal [IPR007187]", "Nucleoporin, Nup133/Nup155-like, N-terminal [IPR014908]", "Nucleoprotein TPR/MLP1 [IPR012929]", "Nucleoredoxin, redox inactive TRX-like domain b' [IPR041861]", "Nucleoside diphosphate kinase-like domain [IPR034907]", "Nucleoside phosphorylase domain [IPR000845]", "Nucleotide exchange factor Fes1 [IPR013918]", "Nucleotidyl transferase domain [IPR005835]", "NudC N-terminal domain [IPR025934]", "NuoE domain [IPR042128]", "Nup358/RanBP2 E3 ligase domain [IPR022011]", "Nup54, C-terminal interacting domain [IPR040985]", "NusG, N-terminal [IPR006645]", "O-GlcNAc transferase, C-terminal [IPR029489]", "OB-fold nucleic acid binding domain, AA-tRNA synthetase-type [IPR004365]", "OBG-type guanine nucleotide-binding (G) domain [IPR031167]", "OCRE domain [IPR041591]", "OCRL1, PH domain [IPR037787]", "OCRL1/INPP5B, INPP5c domain [IPR037793]", "OTU domain [IPR003323]", "Orc1-like, AAA ATPase domain [IPR041664]", "Origin recognition complex subunit 3, N-terminal [IPR045667]", "Origin recognition complex subunit 3, insertion domain [IPR045663]", "Origin recognition complex subunit 3, winged helix C-terminal [IPR040855]", "Orotate phosphoribosyl transferase domain [IPR004467]", "Orotidine 5'-phosphate decarboxylase domain [IPR001754]", "Ovarian carcinoma immunoreactive antigen domain [IPR009764]", "Oxidoreductase FAD/NAD(P)-binding [IPR001433]", "Oxidoreductase, N-terminal domain [IPR041694]", "Oxoglutarate/iron-dependent dioxygenase [IPR005123]", "P-type ATPase, C-terminal [IPR032630]", "P-type ATPase, N-terminal [IPR032631]", "P-type ATPase, haloacid dehalogenase domain [IPR044492]", "P-type trefoil domain [IPR000519]", "PA domain [IPR003137]", "PABP, RNA recognition motif 2 [IPR045305]", "PACSIN1/PACSIN2, SH3 domain [IPR035743]", "PACSIN2, F-BAR domain [IPR037453]", "PADR1 domain [IPR012982]", "PAP/25A-associated [IPR002058]", "PARN, R3H domain [IPR034042]", "PB1 domain [IPR000270]", "PCNA-associated factor, histone-like domain [IPR031444]", "PD-(D/E)XK endonuclease-like domain, AddAB-type [IPR038726]", "PDIP3, RNA recognition motif [IPR034784]", "PDZ domain [IPR001478]", "PET domain [IPR010442]", "PET testin [IPR033724]", "PH-BEACH domain [IPR023362]", "PHR [IPR012983]", "PI31 proteasome regulator, N-terminal [IPR021625]", "PI3K-C2-alpha, catalytic domain [IPR037705]", "PI4-kinase, N-terminal [IPR045495]", "PIK-related kinase [IPR014009]", "PIK-related kinase, FAT [IPR003151]", "PIN domain [IPR002716]", "PITH domain [IPR010400]", "PKD domain [IPR000601]", "PKD/Chitinase domain [IPR022409]", "PLAA family ubiquitin binding domain [IPR015155]", "PLC-gamma, C-terminal SH2 domain [IPR035023]", "PLC-gamma, N-terminal SH2 domain [IPR035024]", "PLD-like domain [IPR032803]", "POLO box domain [IPR000959]", "POPLD domain [IPR012590]", "POTRA domain [IPR034746]", "PP2B, metallophosphatase domain [IPR041751]", "PP5, C-terminal metallophosphatase domain [IPR041753]", "PPIL4-like, cyclophilin domain [IPR035538]", "PPM-type phosphatase domain [IPR001932]", "PPP domain [IPR013235]", "PRKAA1, UBA-like autoinhibitory domain [IPR028797]", "PRKCBP1, PHD finger [IPR044075]", "PRMT5 arginine-N-methyltransferase [IPR035075]", "PRMT5, TIM barrel domain [IPR035247]", "PRMT5, oligomerisation domain [IPR035248]", "PRO8NT domain [IPR012591]", "PROCN domain [IPR012592]", "PROCT domain [IPR012984]", "PRP1 splicing factor, N-terminal [IPR010491]", "PRP8 domain IV core [IPR021983]", "PSF, NOPS domain [IPR034526]", "PSF, RNA recognition motif 1 [IPR034525]", "PSI domain [IPR016201]", "PSP, proline-rich [IPR006568]", "PSP1, RNA recognition motif 1 [IPR034522]", "PSP1, RNA recognition motif 2 [IPR034523]", "PTB/PI domain [IPR006020]", "PTBP1, RNA recognition motif 1 [IPR035000]", "PTBP1, RNA recognition motif 2-like [IPR021790]", "PTBP1, RNA recognition motif 3 [IPR035001]", "PUA domain [IPR002478]", "PUF60, RNA recognition motif 1 [IPR034209]", "PUF60, RNA recognition motif 2 [IPR034211]", "PUF60, RNA recognition motif 3 [IPR034212]", "PUL domain [IPR013535]", "PWI domain [IPR002483]", "PWWP domain [IPR000313]", "Paf1 complex subunit Cdc73, N-terminal domain [IPR032041]", "Palladin, C-terminal immunoglobulin-like domain [IPR033017]", "Pancreatic trypsin inhibitor Kunitz domain [IPR002223]", "Pentacotripeptide-repeat region of PRORP [IPR033443]", "Peptidase C12, C-terminal domain [IPR041507]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase [IPR001578]", "Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394]", "Peptidase C19, ubiquitin-specific peptidase, DUSP domain [IPR006615]", "Peptidase C1A, papain C-terminal [IPR000668]", "Peptidase C1A, propeptide [IPR012599]", "Peptidase C2, calpain, catalytic domain [IPR001300]", "Peptidase C2, calpain, domain III [IPR022683]", "Peptidase C2, calpain, large subunit, domain III [IPR022682]", "Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal [IPR015211]", "Peptidase M1, membrane alanine aminopeptidase [IPR014782]", "Peptidase M13, C-terminal domain [IPR018497]", "Peptidase M13, N-terminal domain [IPR008753]", "Peptidase M14, carboxypeptidase A [IPR000834]", "Peptidase M16, C-terminal [IPR007863]", "Peptidase M16, N-terminal [IPR011765]", "Peptidase M16, middle/third domain [IPR032632]", "Peptidase M16C associated [IPR013578]", "Peptidase M17, leucyl aminopeptidase, C-terminal [IPR000819]", "Peptidase M17, leucyl aminopeptidase, N-terminal [IPR008283]", "Peptidase M20, dimerisation domain [IPR011650]", "Peptidase M24 [IPR000994]", "Peptidase M24, C-terminal domain [IPR032416]", "Peptidase M28 [IPR007484]", "Peptidase M3A/M3B catalytic domain [IPR001567]", "Peptidase M41 [IPR000642]", "Peptidase M41, FtsH extracellular [IPR011546]", "Peptidase M48 [IPR001915]", "Peptidase S16, Lon proteolytic domain [IPR008269]", "Peptidase S24/S26A/S26B/S26C [IPR015927]", "Peptidase S26 [IPR019533]", "Peptidase S53, activation domain [IPR015366]", "Peptidase S59, nucleoporin [IPR007230]", "Peptidase S8/S53 domain [IPR000209]", "Peptidase S8A, tripeptidyl peptidase II [IPR022229]", "Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375]", "Peptidase S9A, N-terminal domain [IPR023302]", "Peptidase family M60 domain [IPR031161]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type [IPR000297]", "Pericentriolar material 1 protein, C-terminal [IPR031446]", "Peripheral subunit-binding domain [IPR004167]", "Peroxiredoxin, C-terminal [IPR019479]", "Peroxisome membrane anchor protein Pex14p, N-terminal [IPR006785]", "PheRS DNA binding domain 2 [IPR040586]", "PheRS, DNA binding domain 1 [IPR040724]", "PheRS, DNA binding domain 3 [IPR040725]", "Phenylacetic acid degradation-related domain [IPR003736]", "Phenylalanine--tRNA ligase beta subunit, B1 domain [IPR040659]", "Phenylalanyl tRNA synthetase beta chain, core domain [IPR041616]", "Phenylalanyl-tRNA synthetase [IPR002319]", "Phosducin, thioredoxin-like domain [IPR024253]", "Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403]", "Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain [IPR000341]", "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PX domain [IPR042133]", "Phosphatidylinositol-specific phospholipase C, X domain [IPR000909]", "Phosphoadenosine phosphosulphate reductase [IPR002500]", "Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain [IPR035077]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal [IPR035078]", "Phosphofructokinase domain [IPR000023]", "Phosphoglucose isomerase, SIS domain 1 [IPR035476]", "Phosphoglucose isomerase, SIS domain 2 [IPR035482]", "Phosphoinositide 3-kinase, accessory (PIK) domain [IPR001263]", "Phospholipase C, phosphatidylinositol-specific, Y domain [IPR001711]", "Phospholipase D-like domain [IPR025202]", "Phospholipase D/Transphosphatidylase [IPR001736]", "Phospholipase/carboxylesterase/thioesterase [IPR003140]", "Phospholipid/glycerol acyltransferase [IPR002123]", "Phosphopantetheine binding ACP domain [IPR009081]", "Phosphoribosylformylglycinamidine synthase, N-terminal [IPR040707]", "Phosphoribosylformylglycinamidine synthase, linker domain [IPR041609]", "Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain [IPR020561]", "Phosphoribosylglycinamide synthetase, C-domain [IPR020560]", "Phosphoribosylglycinamide synthetase, N-terminal [IPR020562]", "Phosphoribosyltransferase domain [IPR000836]", "Phosphorylated adapter RNA export protein, RNA-binding domain [IPR019385]", "Phosphotyrosine protein phosphatase I [IPR023485]", "Phox homology [IPR001683]", "Pinin/SDK [IPR006787]", "Pinin/SDK/MemA protein [IPR006786]", "Pirin, C-terminal domain [IPR008778]", "Pirin, N-terminal domain [IPR003829]", "Plasma membrane calcium transporting P-type ATPase, C-terminal [IPR022141]", "Pleckstrin homology domain 8 [IPR041680]", "Pleckstrin homology domain 9 [IPR041681]", "Pleckstrin homology domain [IPR001849]", "Pleckstrin homology domain, spectrin-type [IPR001605]", "Plectin/S10, N-terminal [IPR005326]", "Polo-like kinase 1, catalytic domain [IPR033702]", "Poly(A) polymerase, RNA-binding domain [IPR007010]", "Poly(A) polymerase, central domain [IPR007012]", "Poly(A)-specific ribonuclease, RNA-binding [IPR014789]", "Poly(ADP-ribose) polymerase, catalytic domain [IPR012317]", "Poly(ADP-ribose) polymerase, regulatory domain [IPR004102]", "Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004]", "Polyamine biosynthesis domain [IPR030374]", "Polycomb group protein, RNA binding region [IPR033763]", "Polycomb protein, VEFS-Box [IPR019135]", "Polyketide synthase, C-terminal extension [IPR032821]", "Polyketide synthase, beta-ketoacyl synthase domain [IPR020841]", "Polyketide synthase, dehydratase domain [IPR020807]", "Polyketide synthase, enoylreductase domain [IPR020843]", "Polyketide synthase, ketoreductase domain [IPR013968]", "Polyketide synthase, phosphopantetheine-binding domain [IPR020806]", "Polymerase, nucleotidyl transferase domain [IPR002934]", "Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2 [IPR034798]", "Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain [IPR032319]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain [IPR015848]", "Polysaccharide biosynthesis domain [IPR021148]", "Pop1, N-terminal [IPR009723]", "Porphobilinogen deaminase, C-terminal [IPR022418]", "Porphobilinogen deaminase, N-terminal [IPR022417]", "Possible tRNA binding domain [IPR027992]", "Post-SET domain [IPR003616]", "Potassium channel tetramerisation-type BTB domain [IPR003131]", "Potentiating neddylation domain [IPR005176]", "Pre-SET domain [IPR007728]", "Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term [IPR021718]", "Pre-mRNA polyadenylation factor Fip1 domain [IPR007854]", "Pre-mRNA processing factor 4 (PRP4)-like [IPR014906]", "Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal [IPR021786]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding [IPR019581]", "Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding [IPR019580]", "Pre-mRNA-splicing factor 19 [IPR013915]", "Pre-mRNA-splicing factor 3 [IPR013881]", "Pre-mRNA-splicing factor 38, C-terminal [IPR024767]", "Pre-rRNA-processing protein Ipi1, N-terminal [IPR024679]", "Pre-rRNA-processing protein RIX1, N-terminal [IPR012583]", "Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal [IPR011945]", "Prenylcysteine lyase [IPR010795]", "Probable RNA-binding protein 19, RNA recognition motif 1 [IPR034418]", "Probable RNA-binding protein 19, RNA recognition motif 2 [IPR034417]", "Probable RNA-binding protein 19, RNA recognition motif 3 [IPR034419]", "Probable RNA-binding protein 19, RNA recognition motif 4 [IPR034420]", "Probable RNA-binding protein 19, RNA recognition motif 5 [IPR034423]", "Probable RNA-binding protein 19, RNA recognition motif 6 [IPR034421]", "Proliferating cell nuclear antigen, PCNA, C-terminal [IPR022649]", "Proliferating cell nuclear antigen, PCNA, N-terminal [IPR022648]", "Proline-tRNA ligase, class II, C-terminal [IPR016061]", "Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]", "Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547]", "Prolyl 4-hydroxylase, alpha subunit [IPR006620]", "Prolyl-tRNA synthetase, catalytic domain [IPR033721]", "Propionyl-coenzyme A carboxylase, BT domain [IPR041265]", "Prostaglandin E synthase 2, C-terminal [IPR034335]", "Proteasomal ATPase OB C-terminal domain [IPR032501]", "Proteasome activator Blm10, mid region [IPR032430]", "Proteasome activator PA28, C-terminal domain [IPR003186]", "Proteasome activator PA28, N-terminal domain [IPR003185]", "Proteasome activator complex subunit 4 C-terminal domain [IPR021843]", "Proteasome alpha-subunit, N-terminal domain [IPR000426]", "Proteasome beta subunit, C-terminal [IPR024689]", "Proteasome component (PCI) domain [IPR000717]", "Protein Kinase B beta, catalytic domain [IPR034677]", "Protein Kinase B, pleckstrin homology domain [IPR039026]", "Protein O-mannosyl-transferase TMTC, DUF1736 [IPR013618]", "Protein RED, C-terminal [IPR012492]", "Protein Smaug, SAM domain [IPR037634]", "Protein disulfide-isomerase A3, first redox inactive TRX-like domain b [IPR041868]", "Protein disulfide-isomerase A4, TRX-like domain b [IPR041866]", "Protein furry, C-terminal [IPR045842]", "Protein kinase A anchor protein, nuclear localisation signal domain [IPR019510]", "Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [IPR002219]", "Protein kinase domain [IPR000719]", "Protein kinase, C-terminal [IPR017892]", "Protein of unknown function DUF3504 [IPR021893]", "Protein of unknown function DUF3715 [IPR022188]", "Protein phosphatase 1 binding domain [IPR029334]", "Protein polybromo-1, Bromodomain 5 [IPR037968]", "Protein quaking, putative nuclear localisation signal [IPR032367]", "Protein-tyrosine phosphatase, catalytic [IPR003595]", "Prp31 C-terminal [IPR019175]", "Pseudouridine synthase II, N-terminal [IPR002501]", "Pseudouridine synthase, TruD, insertion domain [IPR011760]", "Pterin-binding domain [IPR000489]", "Pumilio homology domain [IPR033133]", "Pumilio, RNA binding domain [IPR033712]", "PurE domain [IPR000031]", "PurM-like, C-terminal domain [IPR010918]", "PurM-like, N-terminal domain [IPR016188]", "Putative 5-3 exonuclease [IPR004859]", "Putative RNA methylase domain [IPR000241]", "Putative WW-binding domain and destruction box [IPR033461]", "Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain [IPR004099]", "Pyrroline-5-carboxylate reductase, catalytic, N-terminal [IPR028939]", "Pyrroline-5-carboxylate reductase, dimerisation domain [IPR029036]", "Pyruvate carboxyltransferase [IPR000891]", "Pyruvate kinase, C-terminal [IPR015795]", "Pyruvate kinase, barrel [IPR015793]", "Quinolinate phosphoribosyl transferase, C-terminal [IPR002638]", "Quinolinate phosphoribosyl transferase, N-terminal [IPR022412]", "R3H domain [IPR001374]", "RABX5, catalytic core helical domain [IPR041545]", "RACK7, Bromo domain [IPR037967]", "RAD23A/RAD23B, UBA1 domain [IPR041811]", "RAD50, zinc hook [IPR013134]", "RAP domain [IPR013584]", "RAWUL domain [IPR032443]", "RBM10, OCRE domain [IPR035618]", "RBM12, RNA recognition motif 1 [IPR034591]", "RBM12, RNA recognition motif 2 [IPR034594]", "RBM12, RNA recognition motif 3 [IPR034855]", "RBM12, RNA recognition motif 4 [IPR034856]", "RBM12, RNA recognition motif 5 [IPR034854]", "RBM12B, RNA recognition motif 2 [IPR034588]", "RBM12B, RNA recognition motif 3 [IPR034858]", "RBM14, RNA recognition motif 1 [IPR034506]", "RBM14, RNA recognition motif 2 [IPR034507]", "RBM15, RNA recognition motif 1 [IPR034470]", "RBM15, RNA recognition motif 2 [IPR034472]", "RBM15, RNA recognition motif 3 [IPR034473]", "RBM1CTR [IPR012604]", "RBM25, RNA recognition motif [IPR034268]", "RBM26, RNA recognition motif 1 [IPR034859]", "RBM26-like, RNA recognition motif 2 [IPR039511]", "RBM3/CIRBP, RNA recognition motif [IPR034278]", "RBM34, RNA recognition motif 1 [IPR034220]", "RBM34, RNA recognition motif 2 [IPR034221]", "RBM4, RNA recognition motif 1 [IPR034897]", "RBM4, RNA recognition motif 2 [IPR034898]", "RBM42, RNA recognition motif [IPR034215]", "RBM45, RNA recognition motif 1 [IPR034203]", "RBM45, RNA recognition motif 2 [IPR034206]", "RBM45, RNA recognition motif 3 [IPR034207]", "RBM45, RNA recognition motif 4 [IPR034208]", "RBM8, RNA recognition motif [IPR033744]", "RBP-J/Cbf11/Cbf12, DNA binding [IPR015351]", "RBP-Jkappa, IPT domain [IPR038007]", "RDD [IPR010432]", "RED-like, N-terminal [IPR012916]", "REKLES domain [IPR023334]", "RH1 domain [IPR034743]", "RH2 domain [IPR034744]", "RHIM domain [IPR025735]", "RII binding domain [IPR018459]", "RING finger protein 219, RING finger [IPR035691]", "RING-type zinc-finger, LisH dimerisation motif [IPR027370]", "RIP1, Death domain [IPR037934]", "RL domain [IPR041252]", "RLI, domain 1 [IPR034348]", "RNA 3'-terminal phosphate cyclase domain [IPR023797]", "RNA 3'-terminal phosphate cyclase, insert domain [IPR013791]", "RNA binding activity-knot of a chromodomain [IPR025995]", "RNA exonuclease 4, DEDDh 3'-5' exonuclease domain [IPR037431]", "RNA helicase UPF1, 1B domain [IPR040812]", "RNA helicase UPF1, Cys/His rich zinc-binding domain [IPR018999]", "RNA helicase, DEAD-box type, Q motif [IPR014014]", "RNA polymerase III Rpc82, C -terminal [IPR008806]", "RNA polymerase III subunit RPC82-related, helix-turn-helix [IPR013197]", "RNA polymerase Rpb1, domain 1 [IPR007080]", "RNA polymerase Rpb1, domain 3 [IPR007066]", "RNA polymerase Rpb1, domain 4 [IPR007083]", "RNA polymerase Rpb1, domain 5 [IPR007081]", "RNA polymerase Rpb1, domain 6 [IPR007075]", "RNA polymerase Rpb1, domain 7 [IPR007073]", "RNA polymerase Rpb2, domain 2 [IPR007642]", "RNA polymerase Rpb2, domain 3 [IPR007645]", "RNA polymerase Rpb2, domain 4 [IPR007646]", "RNA polymerase Rpb2, domain 5 [IPR007647]", "RNA polymerase Rpb2, domain 7 [IPR007641]", "RNA polymerase Rpb4/RPC9, core [IPR006590]", "RNA polymerase Rpb7-like , N-terminal [IPR005576]", "RNA polymerase, N-terminal [IPR006592]", "RNA polymerase, Rpb5, N-terminal [IPR005571]", "RNA polymerase, alpha subunit [IPR000722]", "RNA polymerase, beta subunit, protrusion [IPR007644]", "RNA polymerase, subunit H/Rpb5 C-terminal [IPR000783]", "RNA recognition motif domain [IPR000504]", "RNA recognition motif domain, eukaryote [IPR003954]", "RNA recognition motif, spliceosomal PrP8 [IPR019582]", "RNA-binding S4 domain [IPR002942]", "RNA-binding domain, S1 [IPR022967]", "RNA-binding protein 10, RNA recognition motif 2 [IPR034992]", "RNA-binding protein 5, RNA recognition motif 1 [IPR034991]", "RNA-binding protein 5, RNA recognition motif 2 [IPR034993]", "RNA-binding protein Musashi homologue, RNA recognition motif 1 [IPR034130]", "RNA-binding protein Musashi homologue, RNA recognition motif 2 [IPR034126]", "RNA-polymerase II-associated protein 3-like, C-terminal domain [IPR025986]", "RNPS1, RNA recognition motif [IPR034201]", "RNase L inhibitor RLI-like, possible metal-binding domain [IPR007209]", "ROCK, Rho binding domain [IPR015008]", "ROK, N-terminal [IPR012987]", "RPN1, N-terminal [IPR040892]", "RPN13, DEUBAD domain [IPR032368]", "RQC domain [IPR018982]", "RWD domain [IPR006575]", "RZZ complex, subunit KNTC1/ROD, C-terminal [IPR019527]", "Rab geranylgeranyltransferase, alpha subunit, insert-domain [IPR009087]", "Rab-GTPase-TBC domain [IPR000195]", "Rab-binding domain FIP-RBD [IPR019018]", "Rab3-GAP regulatory subunit, N-terminal [IPR032839]", "Rab3GAP catalytic subunit, C-terminal [IPR045698]", "Rab3GAP catalytic subunit, conserved domain [IPR026147]", "Rab3GAP regulatory subunit, C-terminal [IPR029257]", "Rad21/Rec8-like protein, C-terminal, eukaryotic [IPR006909]", "Rad21/Rec8-like protein, N-terminal [IPR006910]", "Rad50, ATP-binding cassette domain [IPR045171]", "Rad50/SbcC-type AAA domain [IPR038729]", "Rad60/SUMO-like domain [IPR022617]", "Radical SAM [IPR007197]", "Radical SAM, C-terminal extension [IPR032432]", "Raly, RNA recognition motif [IPR034502]", "Ran binding domain [IPR000156]", "Ran binding protein 9/10, SPRY domain [IPR035782]", "Ran-GTPase activating protein 1, C-terminal [IPR009109]", "Ran-specific GTPase-activating protein 1, Ran-binding domain [IPR045256]", "Rap1 Myb domain [IPR015010]", "Ras GTPase-activating domain [IPR001936]", "Ras guanine-nucleotide exchange factors catalytic domain [IPR001895]", "Ras-associating (RA) domain [IPR000159]", "Ras-like guanine nucleotide exchange factor, N-terminal [IPR000651]", "RasGAP protein, C-terminal [IPR000593]", "RecF/RecN/SMC, N-terminal [IPR003395]", "Receptor L-domain [IPR000494]", "Redoxin [IPR013740]", "Replication factor A, C-terminal [IPR013955]", "Replication factor C, C-terminal [IPR013748]", "Replication factor-A protein 1, N-terminal [IPR007199]", "Replication protein A, C-terminal [IPR014892]", "Replication protein A, OB domain [IPR031657]", "Replication termination factor 2, RING-finger [IPR027799]", "Reticulon [IPR003388]", "Rho GTPase-activating protein domain [IPR000198]", "Rho GTPase-binding/formin homology 3 (GBD/FH3) domain [IPR014768]", "Rho guanine nucleotide exchange factor 7, SH3 domain [IPR035789]", "Rho-associated protein kinase 1, HR1 [IPR037310]", "Rhodanese-like domain [IPR001763]", "Ribonuclease H1, N-terminal [IPR011320]", "Ribonuclease H2 subunit B, wHTH domain [IPR019024]", "Ribonuclease HII/HIII domain [IPR024567]", "Ribonuclease II/R [IPR001900]", "Ribonuclease, PIN domain [IPR033411]", "Ribonucleoprotein PTB-binding 1, RNA recognition motif 1 [IPR034633]", "Ribonucleotide reductase large subunit, C-terminal [IPR000788]", "Ribonucleotide reductase large subunit, N-terminal [IPR013509]", "Ribonucleotide reductase, class I , alpha subunit [IPR013346]", "Ribose-phosphate pyrophosphokinase, N-terminal domain [IPR029099]", "Ribosomal L28e/Mak16 [IPR029004]", "Ribosomal Protein L6, KOW domain [IPR041997]", "Ribosomal Proteins L2, RNA binding domain [IPR022666]", "Ribosomal RNA adenine methylase transferase, N-terminal [IPR020598]", "Ribosomal RNA methyltransferase FtsJ domain [IPR002877]", "Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381 [IPR024576]", "Ribosomal RNA methyltransferase, Spb1, C-terminal [IPR012920]", "Ribosomal RNA small subunit methyltransferase F, N-terminal [IPR031341]", "Ribosomal RNA-processing protein 14/surfeit locus protein 6, C-terminal domain [IPR029190]", "Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906]", "Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A [IPR023573]", "Ribosomal protein L10e/L16 [IPR016180]", "Ribosomal protein L11, C-terminal [IPR020783]", "Ribosomal protein L11, N-terminal [IPR020784]", "Ribosomal protein L14, KOW motif [IPR041985]", "Ribosomal protein L14e domain [IPR002784]", "Ribosomal protein L18e/L15P [IPR021131]", "Ribosomal protein L19, eukaryotic [IPR033935]", "Ribosomal protein L19/L19e [IPR000196]", "Ribosomal protein L2, C-terminal [IPR022669]", "Ribosomal protein L23/L25, N-terminal [IPR005633]", "Ribosomal protein L26/L24, KOW domain [IPR041988]", "Ribosomal protein L30, N-terminal [IPR012988]", "Ribosomal protein L30, ferredoxin-like fold domain [IPR016082]", "Ribosomal protein L5 eukaryotic, C-terminal [IPR025607]", "Ribosomal protein L5, C-terminal [IPR031309]", "Ribosomal protein L5, N-terminal [IPR031310]", "Ribosomal protein L6, N-terminal [IPR005568]", "Ribosomal protein L6, alpha-beta domain [IPR020040]", "Ribosomal protein L7, eukaryotic/archaeal [IPR035808]", "Ribosomal protein L7/L12, C-terminal [IPR013823]", "Ribosomal protein L7/L12, oligomerisation [IPR008932]", "Ribosomal protein L7Ae/L30e/S12e/Gadd45 [IPR004038]", "Ribosomal protein L9, N-terminal [IPR020070]", "Ribosomal protein S10 domain [IPR027486]", "Ribosomal protein S13/S15, N-terminal [IPR012606]", "Ribosomal protein S23/S25, mitochondrial [IPR023611]", "Ribosomal protein S24/S35, mitochondrial, conserved domain [IPR019349]", "Ribosomal protein S3, C-terminal [IPR001351]", "Ribosomal protein S4, KOW domain [IPR041982]", "Ribosomal protein S4/S9, N-terminal [IPR001912]", "Ribosomal protein S4e, N-terminal [IPR013843]", "Ribosomal protein S4e, central region [IPR013845]", "Ribosomal protein S5, C-terminal [IPR005324]", "Ribosomal protein S5, N-terminal [IPR013810]", "Ribosomal protein S6 kinase alpha-3, C-terminal catalytic domain [IPR041905]", "Ribosomal protein S7 domain [IPR023798]", "Ribosomal protein/NADH dehydrogenase domain [IPR007741]", "Ribosome biogenesis protein BMS1/TSR1, C-terminal [IPR007034]", "Ribosome biogenesis protein Bms1, N-terminal [IPR037875]", "Ribosome maturation protein Sdo1/SBDS, C-terminal [IPR018978]", "Ribosome maturation protein Sdo1/SBDS, N-terminal [IPR019783]", "Ribosome receptor lysine/proline rich [IPR007794]", "Ribosome-associated complex head domain [IPR032003]", "Ricin B, lectin domain [IPR000772]", "Rieske iron-sulphur protein, C-terminal [IPR005805]", "RmlD-like substrate binding domain [IPR029903]", "Rnh202, triple barrel domain [IPR041195]", "Rpn11/EIF3F, C-terminal [IPR024969]", "Rpn13/ADRM1, Pru domain [IPR044868]", "RrmJ-type ribose 2-O-methyltransferase domain [IPR025816]", "Rrp40, S1 domain [IPR037319]", "Rrp44-like cold shock domain [IPR033771]", "RuvB-like, AAA-lid domain [IPR041048]", "S-adenosyl-L-homocysteine hydrolase, NAD binding domain [IPR015878]", "S-adenosylmethionine synthetase, C-terminal [IPR022630]", "S-adenosylmethionine synthetase, N-terminal [IPR022628]", "S-adenosylmethionine synthetase, central domain [IPR022629]", "S1 domain [IPR003029]", "S1-like RNA binding domain [IPR025223]", "S100/CaBP-9k-type, calcium binding, subdomain [IPR013787]", "SAB domain [IPR007477]", "SAC domain [IPR002013]", "SAC3/GANP/THP3, conserved domain [IPR005062]", "SAF domain [IPR013974]", "SAICAR synthetase/ADE2, N-terminal [IPR028923]", "SAM-dependent methyltransferase RsmB/NOP2-type [IPR001678]", "SANT domain [IPR017884]", "SANT/Myb domain [IPR001005]", "SAP domain [IPR003034]", "SART3, RNA recognition motif 1 [IPR034217]", "SART3, RNA recognition motif 2 [IPR034218]", "SCAF4, RNA recognition motif [IPR034369]", "SCP2 sterol-binding domain [IPR003033]", "SDA1 domain [IPR007949]", "SEC23-interacting protein, SAM domain [IPR037603]", "SEP domain [IPR012989]", "SERRATE/Ars2 , C-terminal [IPR007042]", "SERRATE/Ars2, N-terminal [IPR021933]", "SET domain [IPR001214]", "SETD2/Set2, SET domain [IPR044437]", "SF3A2 domain [IPR031781]", "SF3A3 domain [IPR031774]", "SF3B4, RNA recognition motif 1 [IPR034158]", "SF3B4, RNA recognition motif 2 [IPR034159]", "SF3B6, RNA recognition motif [IPR034150]", "SGNH hydrolase-type esterase domain [IPR013830]", "SGS domain [IPR007699]", "SGTA, homodimerisation domain [IPR032374]", "SH2 domain [IPR000980]", "SH3 domain [IPR001452]", "SH3-like domain, bacterial-type [IPR003646]", "SHARP, RNA recognition motif 1 [IPR034172]", "SHARP, RNA recognition motif 2 [IPR034173]", "SHARP, RNA recognition motif 3 [IPR034174]", "SHARP, RNA recognition motif 4 [IPR034175]", "SIS domain [IPR001347]", "SKI-interacting protein SKIP, SNW domain [IPR004015]", "SKP1 component, POZ domain [IPR016073]", "SKP1 component, dimerisation [IPR016072]", "SLC12A transporter, C-terminal [IPR018491]", "SLED domain [IPR021987]", "SLIDE domain [IPR015195]", "SLIRP, RNA recognition motif [IPR034152]", "SMAP1-like, ArfGAP domain [IPR044732]", "SMARCA1, N-terminal [IPR044755]", "SMARCC, C-terminal [IPR032451]", "SMARCC, N-terminal [IPR032450]", "SMARCC, SWIRM-associated domain [IPR032448]", "SMCs flexible hinge [IPR010935]", "SMYD3, SET domain [IPR044420]", "SNAP-25 domain [IPR000928]", "SNARE-complex protein Syntaxin-18, N-terminal [IPR019529]", "SNF2, N-terminal [IPR000330]", "SNX2, PX domain [IPR037918]", "SNX27, PX domain [IPR037833]", "SNX27, RA domain [IPR037835]", "SNX27, atypical FERM-like domain [IPR037827]", "SNX5, PX domain [IPR042135]", "SNX6, PX domain [IPR042136]", "SNX9, SH3 domain [IPR035558]", "SPF45, RNA recognition motif [IPR034653]", "SPRY domain [IPR003877]", "SPRY-associated [IPR006574]", "SR140, RNA recognition motif [IPR035009]", "SRA-YDG [IPR003105]", "SRCR domain [IPR001190]", "SRCR-like domain [IPR017448]", "SREK1, RNA recognition motif 2 [IPR034192]", "SRP9 domain [IPR039432]", "SRSF1, RNA recognition motif 1 [IPR034520]", "SRSF6, RNA recognition motif 1 [IPR034511]", "SRSF7, RNA recognition motif [IPR034651]", "SRSF9, RNA recognition motif 1 [IPR034503]", "SRSF9, RNA recognition motif 2 [IPR034995]", "SSRP1 domain [IPR024954]", "STAG [IPR013721]", "STAM1, SH3 domain [IPR035657]", "STAR protein, homodimerisation region [IPR032377]", "STARD7, START domain [IPR041949]", "START domain [IPR002913]", "STAT transcription factor, DNA-binding [IPR013801]", "STAT transcription factor, all-alpha domain [IPR013800]", "STAT transcription factor, protein interaction [IPR013799]", "STAT1, SH2 domain [IPR035859]", "STAT3, SH2 domain [IPR035855]", "STI1 domain [IPR041243]", "STRBP, first double-stranded RNA binding domain [IPR044472]", "SUI1 domain [IPR001950]", "SUMO-activating enzyme subunit 2, C-terminal domain [IPR032426]", "SUN coiled coil domain 2 [IPR040994]", "SUN domain [IPR012919]", "SUN domain-containing protein 1, N-terminal [IPR032680]", "SUZ-C domain [IPR024642]", "SWAP/Surp [IPR000061]", "SWI/SNF-like complex subunit BAF250, C-terminal [IPR033388]", "SWIB domain [IPR019835]", "SWIB/MDM2 domain [IPR003121]", "SWIRM domain [IPR007526]", "Saccharopine dehydrogenase, NADP binding domain [IPR005097]", "Saccharopine dehydrogenase-like, C-terminal [IPR032095]", "Sam68, tyrosine-rich domain [IPR032335]", "Saposin A-type domain [IPR003119]", "Saposin B type domain [IPR008139]", "Saposin B type, region 2 [IPR008138]", "Saposin-like type B, region 1 [IPR007856]", "Sas10 C-terminal domain [IPR018972]", "Schlafen group 3-like, DNA/RNA helicase domain [IPR018647]", "Schlafen, AlbA_2 domain [IPR007421]", "Sde2, N-terminal ubiquitin domain [IPR024974]", "Sec16, central conserved domain [IPR024340]", "Sec23, C-terminal [IPR037550]", "Sec23/Sec24 beta-sandwich [IPR012990]", "Sec23/Sec24, helical domain [IPR006900]", "Sec23/Sec24, trunk domain [IPR006896]", "Sec24-like, trunk domain [IPR041742]", "Sec39 domain [IPR013244]", "Sec63 domain [IPR004179]", "Sec7 domain [IPR000904]", "Second polo-box domain [IPR033695]", "Sedolisin domain [IPR030400]", "Senescence/spartin-associated, C-terminal [IPR009686]", "Sentrin-specific protease 3/5, conserved domain [IPR045577]", "Septin-type guanine nucleotide-binding (G) domain [IPR030379]", "Sequestosome-1, PB1 domain [IPR034866]", "Sequestosome-1, UBA domain [IPR033741]", "Serine aminopeptidase, S33 [IPR022742]", "Serine hydroxymethyltransferase-like domain [IPR039429]", "Serine proteases, trypsin domain [IPR001254]", "Serine-tRNA ligase catalytic core domain [IPR033729]", "Serine-tRNA synthetase, type1, N-terminal [IPR015866]", "Serine-threonine protein phosphatase, N-terminal [IPR031675]", "Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245]", "Serine/arginine-rich splicing factor SRSF4-like, RNA recognition motif 1 [IPR035585]", "Serine/threonine-protein PRP4, catalytic domain [IPR044092]", "Serine/threonine-protein kinase N, C2 domain [IPR037784]", "Serine/threonine-protein kinase N, first HR1 domain [IPR037313]", "Serine/threonine-protein kinase Nek9, catalytic domain [IPR042767]", "Serine/threonine-protein kinase OSR1/WNK, CCT domain [IPR024678]", "Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase [IPR006186]", "Serpin H1, serpin domain [IPR033830]", "Serpin domain [IPR023796]", "Set2 Rpb1 interacting domain [IPR013257]", "Siah interacting protein, N-terminal [IPR015120]", "Signal recognition particle SRP54, helical bundle [IPR013822]", "Signal recognition particle receptor, alpha subunit, N-terminal [IPR007222]", "Signal recognition particle subunit SRP68, RNA-binding domain [IPR034652]", "Signal recognition particle, SRP54 subunit, GTPase domain [IPR000897]", "Signal recognition particle, SRP54 subunit, M-domain [IPR004125]", "Signal recognition particle, SRP72 subunit, RNA-binding [IPR013699]", "Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal [IPR022752]", "Sin3, C-terminal [IPR031693]", "Sirtuin family, catalytic core domain [IPR026590]", "Sister chromatid cohesion C-terminal domain [IPR024986]", "Ski2, N-terminal domain [IPR040801]", "Sm-like protein Lsm4 [IPR034101]", "Sm-like protein Lsm8 [IPR034103]", "Small G protein signalling modulator 1/2, Rab-binding domain [IPR021935]", "Small GTP-binding protein domain [IPR005225]", "Small acidic protein-like domain [IPR028124]", "Small nuclear ribonucleoprotein D1 [IPR034102]", "Small-subunit processome, Utp12 [IPR007148]", "Small-subunit processome, Utp13 [IPR013934]", "Small-subunit processome, Utp21 [IPR007319]", "Smc1, ATP-binding cassette domain [IPR028468]", "Smc2, ATP-binding cassette domain [IPR027120]", "Snf2, ATP coupling domain [IPR029295]", "Snu114, GTP-binding domain [IPR044121]", "Sof1-like protein [IPR007287]", "Solute carrier family 3 member 2, N-terminal domain [IPR031984]", "Sortilin, C-terminal [IPR031777]", "Sortilin, N-terminal [IPR031778]", "Sorting Nexin 1, PX domain [IPR034901]", "Sorting nexin Vps5-like, C-terminal [IPR015404]", "Sorting nexin protein, WASP-binding domain [IPR019497]", "Sorting nexin, N-terminal [IPR005329]", "Sorting nexin-9, BAR domain [IPR037425]", "Sorting nexin-9, PX domain [IPR037426]", "Spen paralogue and orthologue SPOC, C-terminal [IPR012921]", "Spen paralogue/orthologue C-terminal, metazoa [IPR010912]", "Spermidine synthase, tetramerisation domain [IPR035246]", "Splicing factor 1, helix-hairpin domain [IPR032570]", "Splicing factor 3A subunit 1, conserved domain [IPR022030]", "Splicing factor 3A subunit 1, ubiquitin domain [IPR035563]", "Splicing factor 3B subunit 1 [IPR015016]", "Splicing factor ELAV/Hu, RNA recognition motif 1 [IPR034775]", "Splicing factor RBM39, linker [IPR029123]", "Splicing factor SF3a60 /Prp9 subunit, C-terminal [IPR024598]", "Splicing factor SF3a60 binding domain [IPR021966]", "Spt5 C-terminal domain [IPR024945]", "Spt5 transcription elongation factor, N-terminal [IPR022581]", "Spt5, KOW domain repeat 1 [IPR041973]", "Spt5, KOW domain repeat 2 [IPR041975]", "Spt5, KOW domain repeat 3 [IPR041976]", "Spt5, KOW domain repeat 4 [IPR041977]", "Spt5, KOW domain repeat 5 [IPR041978]", "Spt5, KOW domain repeat 6 [IPR041980]", "Spt6 acidic, N-terminal domain [IPR028083]", "Spt6, SH2 domain [IPR035420]", "Spt6, SH2 domain, C terminus [IPR035018]", "Spt6, SH2 domain, N terminus [IPR035019]", "Squalene cyclase, C-terminal [IPR032696]", "Squalene cyclase, N-terminal [IPR032697]", "Squalene epoxidase [IPR013698]", "Srp40, C-terminal [IPR007718]", "StAR-related lipid transfer protein 3, C-terminal [IPR029867]", "Staphylococcal nuclease (SNase-like), OB-fold [IPR016071]", "Staufen 1, third double-stranded RNA binding domain [IPR044475]", "Staufen, C-terminal [IPR032478]", "Steadiness box (SB) domain [IPR017916]", "Sterile alpha motif domain [IPR001660]", "Sterol-sensing domain [IPR000731]", "Strawberry notch, AAA domain [IPR039187]", "Strawberry notch, helicase C domain [IPR026937]", "Strictosidine synthase, conserved region [IPR018119]", "Stromalin conservative domain [IPR020839]", "Structural maintenance of chromosomes 3, ABC domain, eukaryotic [IPR041741]", "Structural maintenance of chromosomes 4, ABC domain, eukaryotic [IPR041738]", "Succinate dehydogenase/fumarate reductase N-terminal [IPR025192]", "Sulfatase, N-terminal [IPR000917]", "Sulfhydryl oxidase, Trx-like domain [IPR041269]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain [IPR040986]", "Sulphate adenylyltransferase [IPR002650]", "Sulphate adenylyltransferase catalytic domain [IPR024951]", "Suppressor of forked [IPR008847]", "Suppressor of white apricot, N-terminal domain [IPR019147]", "Survival motor neuron [IPR010304]", "Suv3, C-terminal domain 1 [IPR041082]", "Suv3, DEXQ-box helicase domain [IPR044774]", "Suv3, N-terminal [IPR041453]", "Symplekin C-terminal [IPR022075]", "Symplekin/Pta1, N-terminal [IPR032460]", "Synaptic functional regulator FMRP, KH0 domain [IPR040472]", "Synaptotagmin, SMP domain [IPR039010]", "Synaptotagmin-like mitochondrial-lipid-binding domain [IPR031468]", "Syndetin, C-terminal [IPR019514]", "Synembryn [IPR008376]", "Syntaxin, N-terminal domain [IPR006011]", "Syntaxin-5, N-terminal, Sly1p-binding domain [IPR021538]", "Syntaxin-8, SNARE domain [IPR041875]", "TAF6, C-terminal HEAT repeat domain [IPR011442]", "TANK binding kinase 1, ubiquitin-like domain [IPR041087]", "TANK-binding kinase 1, coiled-coil domain 1 [IPR041309]", "TAP C-terminal (TAP-C) domain [IPR005637]", "TAR DNA-binding protein 43, N-terminal [IPR041105]", "TATA box binding protein associated factor (TAF) [IPR004823]", "TATA-binding protein interacting (TIP20) [IPR013932]", "TBC1D8B, PH-GRAM domain 1 [IPR036012]", "TBC1D8B, PH-GRAM domain 2 [IPR036015]", "TBCE, ubiquitin-like (Ubl) domain [IPR044079]", "TCB1D9/TCB1D9B, PH-GRAM domain 1 [IPR036014]", "TCB1D9/TCB1D9B, PH-GRAM domain 2 [IPR036017]", "TFG box [IPR025768]", "TFG, PB1 domain [IPR034857]", "TFIID subunit TAF5, NTD2 domain [IPR007582]", "TGS [IPR004095]", "THIF-type NAD/FAD binding fold [IPR000594]", "THO complex subunit 2, N-terminal domain [IPR032302]", "THO complex, subunitTHOC2, C-terminal [IPR021418]", "THO complex, subunitTHOC2, N-terminal [IPR021726]", "THUMP domain [IPR004114]", "TIA-1, RNA recognition motif 2 [IPR034830]", "TIA-1, RNA recognition motif 3 [IPR034832]", "TIAR, RNA recognition motif 1 [IPR034492]", "TIAR, RNA recognition motif 2 [IPR034494]", "TIAR, RNA recognition motif 3 [IPR034496]", "TIF1-beta, RING finger, HC subclass [IPR042713]", "TIP49, P-loop domain [IPR010339]", "TOG domain [IPR034085]", "TOPK, catalytic domain [IPR041989]", "TOPRIM domain [IPR006171]", "TPX2 central domain [IPR027330]", "TPX2, C-terminal [IPR027329]", "TRAM domain [IPR002792]", "TRAM/LAG1/CLN8 homology domain [IPR006634]", "TRAM1-like protein [IPR013599]", "TRASH domain [IPR011017]", "TRF2-interacting telomeric protein/Rap1, C-terminal [IPR021661]", "TRIAD supradomain [IPR044066]", "TRIM21, PRY/SPRY domain [IPR035831]", "TRIM25, PRY/SPRY domain [IPR042753]", "TRMT2A, RNA recognition motif [IPR034262]", "TROVE domain [IPR008858]", "TSG101 and ALIX binding domain of CEP55 [IPR022008]", "TUG ubiquitin-like domain [IPR021569]", "TUTase nucleotidyltransferase domain [IPR045100]", "Talin, N-terminal F0 domain [IPR032425]", "Talin, central [IPR015224]", "Talin-1/2, rod-segment [IPR037438]", "Target SNARE coiled-coil homology domain [IPR000727]", "TatSF1-like, RNA recognition motif 1 [IPR034392]", "Telomere length regulation protein, conserved domain [IPR019337]", "Telomere-associated protein Rif1, N-terminal [IPR022031]", "Tensin phosphatase, C2 domain [IPR014020]", "Tensin-type phosphatase domain [IPR029023]", "Testin, LIM domain 1 [IPR034958]", "Testin, LIM domain 2 [IPR034959]", "Testin, LIM domain 3 [IPR034960]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain [IPR020631]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain [IPR020630]", "Tetrapyrrole methylase [IPR000878]", "Tetratricopeptide repeat-like domain [IPR018704]", "Tetratricopeptide, SHNi-TPR domain [IPR019544]", "Tfc3, extended winged-helix domain [IPR035625]", "Thiamine pyrophosphate enzyme, C-terminal TPP-binding [IPR011766]", "Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain [IPR012001]", "Thiamine pyrophosphate enzyme, central domain [IPR012000]", "Thioesterase [IPR001031]", "Thioesterase domain [IPR006683]", "Thiolase, C-terminal [IPR020617]", "Thiolase, N-terminal [IPR020616]", "Thioredoxin domain [IPR013766]", "Thioredoxin domain-containing protein 17-like domain [IPR010357]", "Thioredoxin-like fold [IPR012336]", "Thioredoxin-related transmembrane protein 2, thioredoxin domain [IPR037463]", "Threonine-tRNA ligase catalytic core domain [IPR033728]", "Threonyl/alanyl tRNA synthetase, SAD [IPR012947]", "Thymidylate kinase-like domain [IPR039430]", "Thymidylate synthase/dCMP hydroxymethylase domain [IPR023451]", "Tim44-like domain [IPR007379]", "TopBP1, first BRCT domain [IPR044737]", "Topoisomerase I C-terminal domain [IPR025834]", "Trafficking protein particle complex subunit 11 [IPR021773]", "Trafficking protein particle complex subunit 11, C-terminal [IPR025876]", "Trans-isoprenyl diphosphate synthases, head-to-head [IPR033904]", "Transcription elongation factor S-II, central domain [IPR003618]", "Transcription elongation factor Spt6, YqgF domain [IPR028231]", "Transcription elongation factor Spt6, helix-hairpin-helix motif [IPR032706]", "Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type [IPR003617]", "Transcription factor 20, ePHD domain [IPR041972]", "Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958]", "Transcription factor IIIC subunit 5, HTH domain [IPR019136]", "Transcription factor IIIC subunit Tfc1/Sfc1, triple barrel domain [IPR041499]", "Transcription factor IIIC, 90kDa subunit, N-terminal [IPR024761]", "Transcription factor IIIC, putative zinc-finger [IPR024764]", "Transcription factor IIS, N-terminal [IPR017923]", "Transcriptional coactivator p15 (PC4), C-terminal [IPR003173]", "Transcriptional repressor p66, coiled-coil MBD2-interaction domain [IPR032346]", "Transferrin receptor protein 1/2, PA domain [IPR037324]", "Transferrin receptor-like, dimerisation domain [IPR007365]", "Transforming acidic coiled-coil-containing protein, C-terminal [IPR007707]", "Transketolase, C-terminal domain [IPR033248]", "Transketolase, N-terminal [IPR005474]", "Transketolase-like, pyrimidine-binding domain [IPR005475]", "Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain [IPR014038]", "Translation elongation factor EFG/EF2, domain IV [IPR005517]", "Translation elongation factor EFTs/EF1B, dimerisation [IPR014039]", "Translation elongation factor EFTu-like, domain 2 [IPR004161]", "Translation elongation factor EFTu/EF1A, C-terminal [IPR004160]", "Translation elongation factor, IF5A C-terminal [IPR020189]", "Translation initiation factor IF- 2, domain 3 [IPR023115]", "Translation initiation factor IF-2, domain II [IPR044145]", "Translation initiation factor IF2/IF5 domain [IPR002735]", "Translation initiation factor eIF-2B subunit epsilon, N-terminal [IPR035543]", "Translation initiation factor eIF-2B subunit epsilon, W2 domain [IPR044123]", "Translation initiation factor, beta propellor-like domain [IPR013979]", "Translational (tr)-type GTP-binding domain [IPR000795]", "Translationally controlled tumour protein (TCTP) domain [IPR034737]", "Translocon Sec61/SecY, plug domain [IPR019561]", "Transmembrane protein 201, C-terminal [IPR018861]", "Treacle protein domain [IPR003993]", "Tripartite DENN domain [IPR037516]", "Tripeptidyl-peptidase II domain [IPR034051]", "TrmE-type guanine nucleotide-binding domain [IPR031168]", "TryX and NRX, thioredoxin domain [IPR045870]", "Tubulin-folding cofactor B, N-terminal ubiquitin-like domain [IPR045172]", "Tubulin-specific chaperone D, C-terminal [IPR022577]", "Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]", "Tubulin/FtsZ, GTPase domain [IPR003008]", "Tudor domain [IPR002999]", "Tuftelin interacting protein, N-terminal domain [IPR022159]", "Tumour suppressor p53-binding protein-1 Tudor domain [IPR015125]", "Tyrosine-protein kinase BAZ1B, bromodomain [IPR037375]", "Tyrosine-protein kinase, catalytic domain [IPR020635]", "Tyrosine-specific protein phosphatase, PTPase domain [IPR000242]", "Tyrosine-specific protein phosphatases domain [IPR000387]", "U-box domain [IPR003613]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 1 [IPR034407]", "U1 small nuclear ribonucleoprotein A, RNA recognition motif 2 [IPR034409]", "U1 small nuclear ribonucleoprotein of 70kDa N-terminal [IPR022023]", "U1-C, C2H2-type zinc finger [IPR013085]", "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 2 [IPR034562]", "U2 small nuclear ribonucleoprotein B'', RNA recognition motif 1 [IPR034564]", "U2A'/phosphoprotein 32 family A, C-terminal [IPR003603]", "U3 small nucleolar RNA-associated protein 10, N-terminal [IPR022125]", "U3 small nucleolar RNA-associated protein 15, C-terminal [IPR018983]", "UAS [IPR006577]", "UBX domain [IPR001012]", "UDP-glucose/GDP-mannose dehydrogenase, C-terminal [IPR014027]", "UDP-glucose/GDP-mannose dehydrogenase, N-terminal [IPR001732]", "UDP-glucose/GDP-mannose dehydrogenase, dimerisation [IPR014026]", "UDP-glucose:glycoprotein glucosyltransferase, thioredoxin-like domain 4 [IPR040525]", "UGGT, thioredoxin-like domain 1 [IPR040693]", "UGGT, thioredoxin-like domain 2 [IPR040694]", "UGGT, thioredoxin-like domain 3 [IPR040692]", "UHRF1, tandem tudor domain [IPR021991]", "UNC-45/Cro1/She4, central domain [IPR024660]", "UPF0113, PUA domain [IPR005155]", "UPF0113, pre-PUA domain [IPR040598]", "UPF3 domain [IPR005120]", "UPF3B, RNA recognition motif-like domain [IPR034979]", "USP8 dimerisation domain [IPR015063]", "UVR domain [IPR001943]", "Ubiquinol-cytochrome c reductase 8kDa, N-terminal [IPR015248]", "Ubiquinol-cytochrome c reductase, iron-sulphur subunit [IPR006317]", "Ubiquitin E2 variant, N-terminal [IPR008883]", "Ubiquitin carboxyl-terminal hydrolase 47, C-terminal [IPR045578]", "Ubiquitin carboxyl-terminal hydrolase 5, UBA1 domain [IPR041812]", "Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain [IPR024729]", "Ubiquitin carboxyl-terminal hydrolase, C-terminal [IPR029346]", "Ubiquitin conjugation factor E4, core [IPR019474]", "Ubiquitin specific protease domain [IPR028889]", "Ubiquitin system component CUE [IPR003892]", "Ubiquitin-activating enzyme E1, C-terminal [IPR018965]", "Ubiquitin-activating enzyme E1, FCCH domain [IPR032418]", "Ubiquitin-activating enzyme E1, four-helix bundle [IPR032420]", "Ubiquitin-activating enzyme, SCCH domain [IPR019572]", "Ubiquitin-associated domain [IPR015940]", "Ubiquitin-conjugating enzyme E2 [IPR000608]", "Ubiquitin-like domain [IPR000626]", "Ubiquitin-like domain, USP-type [IPR028135]", "Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain [IPR032353]", "Ubiquitin-specific peptidase 48 [IPR033841]", "Ubiquitin-specific-processing protease 48, Ubl domain [IPR044743]", "Ubiquitin/SUMO-activating enzyme ubiquitin-like domain [IPR028077]", "Ubiquitinyl hydrolase, variant UBP zinc finger [IPR041432]", "Ubiquitinyl hydrolase-L5 [IPR033837]", "Ulp1 protease family, C-terminal catalytic domain [IPR003653]", "Uncharacterised domain CHP00451 [IPR004521]", "Uncharacterised domain NUC130/133, N-terminal [IPR012977]", "Uncharacterised domain NUC173 [IPR012978]", "Uncharacterised domain NUC202 [IPR012980]", "Up-frameshift suppressor 2, C-terminal [IPR007193]", "Uracil-DNA glycosylase-like [IPR005122]", "Uso1/p115-like vesicle tethering protein, C-terminal [IPR006955]", "VASP tetramerisation [IPR014885]", "VHS domain [IPR002014]", "VIP36, lectin domain [IPR035664]", "VPS10 [IPR006581]", "VPS9 domain [IPR003123]", "VWA N-terminal [IPR013608]", "Vacuolar protein sorting-associated protein 4, MIT domain [IPR045253]", "Vacuolar protein sorting-associated protein 54, N-terminal [IPR019515]", "Valyl tRNA synthetase, anticodon-binding domain [IPR033705]", "Vertebrate SNX3, PX domain [IPR042137]", "Vertebrate ubiquitin-conjugating enzyme E2 K, UBA domain [IPR042599]", "Vesicle tethering protein Uso1/P115-like , head domain [IPR006953]", "Vicinal oxygen chelate (VOC) domain [IPR037523]", "Vinculin-binding site-containing domain [IPR015009]", "Virilizer, N-terminal [IPR031801]", "Vitamin B12-dependent methionine synthase, activation domain [IPR004223]", "Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region [IPR013680]", "Vps16, C-terminal [IPR006925]", "Vps16, N-terminal [IPR006926]", "Vps4 oligomerisation, C-terminal [IPR015415]", "Vta1, C-terminal [IPR041212]", "Vta1/callose synthase, N-terminal [IPR039431]", "W2 domain [IPR003307]", "WAPL domain [IPR012502]", "WD repeat-containing protein 18, C-terminal domain [IPR026987]", "WGR domain [IPR008893]", "WH1/EVH1 domain [IPR000697]", "WHEP-TRS domain [IPR000738]", "WHIM1 domain [IPR028942]", "WHIM2 domain [IPR028941]", "WIBG, Mago-binding [IPR015362]", "WSTF/Acf1/Cbp146 [IPR013136]", "WW domain [IPR001202]", "WWE domain [IPR004170]", "Wings apart-like protein, C-terminal [IPR022771]", "Wolframin, EF-hand domain [IPR045460]", "Wolframin, OB-fold domain [IPR045461]", "Wolframin, cysteine-rich domain [IPR045400]", "XPC-binding domain [IPR015360]", "XPG, N-terminal [IPR006085]", "XPG-I domain [IPR006086]", "XRCC1, first (central) BRCT domain [IPR045080]", "XRN2-binding (XTBD) domain [IPR021859]", "Xrn1, D1 domain [IPR040992]", "Xrn1, helical domain [IPR041412]", "YKT6, SNARE motif [IPR045848]", "YTH domain [IPR007275]", "YchF, C-terminal domain [IPR013029]", "YchF, N-terminal [IPR041706]", "YjeF N-terminal domain [IPR004443]", "YqgF/RNase H-like domain [IPR006641]", "YrdC-like domain [IPR006070]", "Z-binding domain [IPR042371]", "ZAP, helix turn helix N-terminal domain [IPR041360]", "ZAP, zinc finger [IPR040954]", "ZC3H15/TMA46 family, C-terminal [IPR032378]", "ZCRB1, RNA recognition motif [IPR034219]", "ZMYND8/11, PWWP domain [IPR035505]", "ZO-1, SH3 domain [IPR035597]", "ZU5 domain [IPR000906]", "Zasp-like motif [IPR006643]", "Zinc finger C2H2 AKAP95-type [IPR034736]", "Zinc finger C2H2-type [IPR013087]", "Zinc finger, B-box, chordata [IPR020457]", "Zinc finger, C2H2, LYAR-type [IPR014898]", "Zinc finger, C2HC5-type [IPR009349]", "Zinc finger, C3HC-like [IPR012935]", "Zinc finger, C3HC4 RING-type [IPR018957]", "Zinc finger, C5HC2-type [IPR004198]", "Zinc finger, CCCH-type [IPR000571]", "Zinc finger, CCHC-type [IPR001878]", "Zinc finger, CHCC-type [IPR019401]", "Zinc finger, CHHC-type [IPR012996]", "Zinc finger, CW-type [IPR011124]", "Zinc finger, CXXC-type [IPR002857]", "Zinc finger, ClpX C4-type [IPR010603]", "Zinc finger, DNA-directed DNA polymerase, family B, alpha [IPR015088]", "Zinc finger, FCS-type [IPR012313]", "Zinc finger, FPG/IleRS-type [IPR010663]", "Zinc finger, FYVE-related [IPR017455]", "Zinc finger, GATA-type [IPR000679]", "Zinc finger, LIM-type [IPR001781]", "Zinc finger, MIZ-type [IPR004181]", "Zinc finger, MYM-type [IPR010507]", "Zinc finger, MYND-type [IPR002893]", "Zinc finger, PARP-type [IPR001510]", "Zinc finger, PHD-finger [IPR019787]", "Zinc finger, PHD-type [IPR001965]", "Zinc finger, RING-type [IPR001841]", "Zinc finger, RanBP2-type [IPR001876]", "Zinc finger, Sec23/Sec24-type [IPR006895]", "Zinc finger, TFIIS-type [IPR001222]", "Zinc finger, UBP-type [IPR001607]", "Zinc finger, UBR-type [IPR003126]", "Zinc finger, ZPR1-type [IPR004457]", "Zinc finger, ZZ-type [IPR000433]", "Zinc finger, double-stranded RNA binding [IPR022755]", "Zinc knuckle CX2CX3GHX4C [IPR025829]", "Zinc ribbon, NADH pyrophosphatase [IPR015376]", "Zinc-finger C2H2-type 11 [IPR041697]", "Zinc-finger CCCH domain [IPR041686]", "Zinc-ribbon domain [IPR026870]", "Zn-dependent metallo-hydrolase, RNA specificity domain [IPR011108]", "cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain [IPR003117]", "cGMP-dependent protein kinase, interacting domain [IPR031775]", "dUTPase, trimeric [IPR033704]", "dUTPase-like [IPR029054]", "eIF3 subunit M, C-terminal helix domain [IPR040750]", "eIF3B, RNA recognition motif [IPR034363]", "eIF3G, RNA recognition motif [IPR034240]", "eIF3h, C-terminal [IPR045810]", "eIF4H, RNA recognition motif [IPR034229]", "eRF1 domain 1/Pelota-like [IPR005140]", "eRF1 domain 2 [IPR005141]", "eRF1 domain 3 [IPR005142]", "hnRNP A0, RNA recognition motif 1 [IPR034801]", "hnRNP A1, RNA recognition motif 1 [IPR034845]", "hnRNP A1, RNA recognition motif 2 [IPR034803]", "hnRNP A2/B1, RNA recognition motif 1 [IPR034486]", "hnRNP A3, RNA recognition motif 1 [IPR034513]", "hnRNP A3, RNA recognition motif 2 [IPR034516]", "hnRNP DL, RNA recognition motif 1 [IPR034847]", "hnRNP-L, RNA recognition motif 1 [IPR035005]", "hnRNP-L, RNA recognition motif 2 [IPR035008]", "hnRNP-L, RNA recognition motif 3 [IPR034816]", "hnRNP-L, RNA recognition motif 4 [IPR034817]", "hnRNPAB, RNA recognition motif 1 [IPR034846]", "hnRNPH3, RNA recognition motif 2 [IPR034970]", "hnRNPH3, RNA recognition motif 3 [IPR034969]", "hnRNPM, RNA recognition motif 3 [IPR034990]", "mRNA (guanine-N(7))-methyltransferase domain [IPR004971]", "mRNA splicing factor Cwf21 domain [IPR013170]", "p21 activated kinase binding domain [IPR033923]", "p21-activated kinase 2, catalytic domain [IPR035064]", "p53 transactivation domain [IPR013872]", "p53, DNA-binding domain [IPR011615]", "p53, tetramerisation domain [IPR010991]", "p54nrb, RNA recognition motif 1 [IPR034552]", "rRNA-processing arch domain [IPR025696]", "snRNP70, RNA recognition motif [IPR034143]", "tRNA methyltransferase TRM10-type domain [IPR028564]", "tRNA methyltransferase TRMD/TRM10-type domain [IPR016009]", "tRNA pseudouridylate synthase B, C-terminal [IPR032819]", "tRNA synthetase, B5-domain [IPR005147]", "tRNA synthetases class I, catalytic domain [IPR032678]", "tRNA(Met) cytidine acetyltransferase TmcA, N-terminal [IPR013562]", "tRNA-binding domain [IPR002547]", "tRNase Z endonuclease [IPR027794]", "v-SNARE, coiled-coil homology domain [IPR042855]", "von Willebrand factor, type A [IPR002035]"], "available_proteins": ["AACS", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABRAXAS2", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN4", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADRM1", "ADSL", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK2", "AK3", "AKAP1", "AKAP12", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG1", "ALG5", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC2", "ANAPC5", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANO6", "ANP32A", "ANP32B", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "APLP2", "APMAP", "APOBEC3C", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARHGAP1", "ARHGAP17", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6", "ARL8A", "ARMCX3", "ARMT1", "ASAH1", "ASCC1", "ASCC3", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATIC", "ATP11C", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "ATP6V1H", "ATXN10", "ATXN2L", "AUP1", "BAG6", "BAIAP2", "BAZ1A", "BAZ1B", "BCAP31", "BCOR", "BCS1L", "BIRC6", "BLVRA", "BLVRB", "BMS1", "BOP1", "BPTF", "BRD1", "BRD2", "BRIX1", "BSG", "BTF3", "BUB1B", "BZW1", "BZW2", "C11orf58", "C1orf35", "CACNA2D1", "CACYBP", "CAD", "CALU", "CAMK2G", "CAND1", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CARM1", "CARS", "CASK", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC93", "CCNB1", "CCNB2", "CD2AP", "CD2BP2", "CD47", "CDC23", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA2", "CDH2", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDKAL1", "CDKN2AIP", "CEBPZ", "CELF1", "CENPF", "CEP170", "CEP44", "CEP55", "CERS2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHD1", "CHD1L", "CHD4", "CHD7", "CHEK2", "CHERP", "CHID1", "CHORDC1", "CHTF18", "CHTOP", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP2L", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLIC1", "CLIC4", "CLINT1", "CLPB", "CLPX", "CLTC", "CLUH", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNPY2", "COA3", "COG2", "COG4", "COIL", "COLEC12", "COMMD4", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7B", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX2", "COX6C", "CPD", "CPNE1", "CPNE3", "CPSF1", "CPSF2", "CPSF3", "CPSF7", "CPT2", "CRKL", "CRYZ", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSRP2", "CSTB", "CSTF1", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNBL1", "CTPS1", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC22", "CWF19L1", "CYB5B", "CYB5D2", "CYB5R3", "CYFIP1", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBR1", "DBT", "DCAF1", "DCAF13", "DCTN1", "DCUN1D1", "DDA1", "DDB1", "DDI2", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DFFA", "DHCR24", "DHFR", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX34", "DHX35", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DIAPH3", "DIDO1", "DIMT1", "DIP2B", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC17", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNTTIP2", "DOCK1", "DOCK7", "DPH5", "DPM1", "DPYSL2", "DR1", "DRG1", "DRG2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "EARS2", "ECE1", "ECI2", "EDC4", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EIF2A", "EIF2AK2", "EIF2B3", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMOD2", "ELOB", "ELOC", "ELP3", "EMC1", "EMC7", "EMD", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX1", "EPHX2", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERCC6L", "ERGIC1", "ERGIC2", "ERGIC3", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERP29", "ERP44", "ESF1", "ESYT1", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FAF1", "FAF2", "FAH", "FAHD1", "FAM208A", "FAM208B", "FAM49B", "FAM8A1", "FANCI", "FAR1", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD5", "FBXO7", "FCGRT", "FDFT1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP10", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNDC3A", "FOXRED1", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDAP2", "GDPD1", "GEMIN5", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLB1L2", "GLDC", "GLO1", "GLOD4", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPPA", "GMPS", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGB1", "GORASP2", "GOT1", "GOT2", "GPATCH4", "GPD1L", "GPD2", "GPHN", "GPI", "GPS1", "GRB2", "GRHPR", "GRSF1", "GRWD1", "GSDME", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GTF3C1", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDLBP", "HEATR1", "HEATR6", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMGB1", "HMGB2", "HMGB3", "HMGCR", "HMGCS1", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA4", "HSPA4L", "HSPB1", "HSPB11", "HSPBP1", "HSPH1", "HTATSF1", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFNGR1", "IFT27", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPDH2", "INCENP", "INTS1", "INTS14", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQSEC1", "IRF2BPL", "IRS4", "ISOC1", "ISYNA1", "ITCH", "ITGB1", "ITM2B", "ITPK1", "IVD", "IWS1", "JMJD6", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0100", "KIAA0319L", "KIAA1147", "KIF11", "KIF14", "KIF18A", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIN", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LGALS3BP", "LIG3", "LIMA1", "LIN28B", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC47", "LRSAM1", "LSM12", "LSM14A", "LSM2", "LSM4", "LSM6", "LSM7", "LSM8", "LSS", "LTA4H", "LYAR", "LYPLA1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAK16", "MANBA", "MANF", "MAP2K1", "MAP2K4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARS", "MAT2A", "MAT2B", "MATR3", "MBD3", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDC1", "MDH1", "MDH2", "MDN1", "ME2", "MECP2", "METTL13", "MFAP1", "MFF", "MFN1", "MFN2", "MFSD10", "MFSD14B", "MFSD8", "MGME1", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MINDY3", "MIPEP", "MKI67", "MKRN2", "MLEC", "MMS19", "MOGS", "MORC2", "MORF4L1", "MORF4L2", "MOV10", "MPHOSPH8", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MRE11", "MRPL11", "MRPL12", "MRPL15", "MRPL2", "MRPL24", "MRPL39", "MRPL43", "MRPL44", "MRPL45", "MRPL9", "MRPS23", "MRPS25", "MRPS35", "MRPS5", "MRPS7", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MTX3", "MUT", "MYADM", "MYCBP2", "MYEF2", "MYH10", "MYH9", "MYL6", "MYL6B", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA40", "NAA50", "NAE1", "NAGLU", "NAMPT", "NANS", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NCAPD2", "NCAPD3", "NCAPG", "NCBP1", "NCL", "NCLN", "NCSTN", "NDUFA10", "NDUFA9", "NDUFAF1", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV2", "NECAP2", "NEDD4L", "NEFM", "NEK9", "NELFE", "NENF", "NF1", "NFATC2IP", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIPSNAP2", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOSIP", "NOVA2", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NTPCR", "NUB1", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP50", "NUP54", "NUP62", "NUP98", "NUPL2", "NUTF2", "NVL", "NXF1", "NXN", "OCIAD1", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "OXCT1", "P3H1", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PAPSS2", "PARK7", "PARN", "PARP1", "PBDC1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDZD11", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PFAS", "PFKL", "PFKM", "PFKP", "PGD", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF3", "PHF6", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PICALM", "PIK3C2A", "PIK3R4", "PIN4", "PIR", "PITHD1", "PITRM1", "PKM", "PKN2", "PLAA", "PLCG1", "PLD3", "PLD6", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "POGZ", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "POP1", "POR", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL4", "PPM1F", "PPM1G", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP3CA", "PPP4R3A", "PPP5C", "PPP6C", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREP", "PREPL", "PRKAA1", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38A", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PRSS3", "PRTFDC1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSPC1", "PTBP1", "PTCD1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPN1", "PTPN11", "PTPRF", "PUF60", "PUM1", "PUM3", "PUS7", "PWP2", "PWWP2A", "PYCR1", "PYCR2", "PYM1", "QARS", "QKI", "QPRT", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB23", "RAB2A", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RAD21", "RAD23B", "RAD50", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAPGEF2", "RARS", "RAVER1", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPJ", "RCL1", "RCN1", "RCN2", "RCOR1", "RDX", "RECQL", "REPS1", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIF1", "RIPK1", "RNASEH2A", "RNASEH2B", "RNF14", "RNF2", "RNF20", "RNF219", "RNF40", "RNMT", "RNPEP", "RNPS1", "ROCK1", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL11", "RPL12", "RPL14", "RPL18", "RPL18A", "RPL19", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL30", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS2", "RPS20", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS9", "RPSA", "RRBP1", "RREB1", "RRM1", "RRP12", "RSF1", "RSL24D1", "RTFDC1", "RTN3", "RTN4", "RTN4IP1", "RUVBL1", "RUVBL2", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAMM50", "SAR1A", "SARNP", "SARS", "SARS2", "SART3", "SBDS", "SBNO1", "SCAF11", "SCAF4", "SCCPDH", "SCML2", "SCO2", "SCP2", "SCRIB", "SCYL2", "SDAD1", "SDE2", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC14L2", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SETD2", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHMT2", "SIN3A", "SIRT1", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC25A12", "SLC25A13", "SLC25A24", "SLC27A4", "SLC2A1", "SLC38A1", "SLC3A2", "SLC7A1", "SLC9A3R1", "SLC9A6", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMU1", "SMYD3", "SNAP23", "SNAP29", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPART", "SPC25", "SPECC1", "SPECC1L", "SPEN", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRFBP1", "SRI", "SRM", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STIP1", "STOML2", "STRBP", "STUB1", "STX12", "STX18", "STX4", "STX5", "STX7", "STX8", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SV2A", "SWAP70", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TAB1", "TACC3", "TAF15", "TAF5", "TAF6L", "TAGLN2", "TAOK1", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D15", "TBC1D4", "TBC1D8B", "TBC1D9B", "TBCB", "TBCD", "TBCE", "TBK1", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TECR", "TELO2", "TERF2IP", "TES", "TEX10", "TFAM", "TFB1M", "TFG", "TFIP11", "TFRC", "THOC1", "THOC2", "THOC3", "THOP1", "THUMPD1", "TIA1", "TIAL1", "TIMM44", "TIMM50", "TJP1", "TKT", "TLN1", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM201", "TMEM205", "TMEM97", "TMPO", "TMPO", "TMPPE", "TMTC3", "TMX1", "TMX2", "TMX4", "TNPO1", "TNPO3", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOX4", "TP53", "TP53BP1", "TP53BP2", "TPP1", "TPP2", "TPR", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSR1", "TSR3", "TST", "TSTA3", "TTC4", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWNK", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TXNRD2", "TYMS", "U2AF2", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBFD1", "UBL5", "UBLCP1", "UBQLN4", "UBR1", "UBR4", "UBR5", "UBTF", "UBXN4", "UCHL5", "UGDH", "UGGT1", "UHRF1", "UMPS", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCRC1", "UQCRC2", "UQCRFS1", "URB1", "URB2", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP33", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP20", "UTP3", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VAT1", "VCP", "VIM", "VIRMA", "VPS16", "VPS29", "VPS4A", "VPS4B", "VPS50", "VRK1", "VRK3", "VTA1", "VWA8", "WAPL", "WARS", "WBP2", "WDHD1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR43", "WDR46", "WFS1", "WIZ", "WNK1", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YBX1", "YBX3", "YKT6", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBTB10", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCRB1", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM4", "ZMYND8", "ZNF207", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF638", "ZNF687", "ZPR1", "ZRANB2", "ZYX"], "leading_proteins": ["AARS2", "ACLY", "ACOX3", "ACTN4", "AKAP8", "AKAP8L", "ANK3", "ANKRD17", "AP3S1", "APEH", "APPL1", "ARFGAP2", "ARHGEF7", "ASCC1", "ASNS", "ASPSCR1", "ATP1A1", "ATP2A2", "BSG", "CAD", "CALU", "CASK", "CBX1", "CBX5", "CCNB1", "CERS2", "CIRBP", "CNNM3", "CNNM4", "COPS8", "CSE1L", "CSK", "CSTF3", "CYB5B", "CYB5D2", "DCAF13", "DIAPH3", "DNAJA2", "DNAJB11", "DNAJC2", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "EHD4", "EIF2A", "EIF3B", "EIF4B", "ELOC", "ELP3", "EPHX1", "ERAP2", "ERMP1", "EWSR1", "EXOSC2", "EXOSC8", "F11R", "FAF1", "FAF2", "FARP2", "FCGRT", "FH", "FMR1", "FUBP1", "FUBP3", "FUCA2", "FUS", "FXR1", "FXR2", "GAK", "GALNT7", "GLB1L2", "GLOD4", "GLRX5", "GM2A", "GSTO1", "GUSB", "HDGFL2", "HLA-A", "HLA-B", "HLA-C", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPR", "HNRNPU", "HNRNPUL2", "IDH2", "IFNGR1", "IGF2BP2", "IGF2BP3", "IPO7", "KHDRBS1", "KHDRBS3", "KHSRP", "KMT2A", "KPNA1", "KPNA3", "KPNA4", "LARP4", "LARP4B", "LARP7", "LBR", "LCLAT1", "LNPEP", "LPCAT1", "LTA4H", "MAPRE2", "MATR3", "MFSD14B", "MFSD8", "MID1", "MKRN2", "MPP2", "MPP6", "MRPS7", "MSH2", "MSH6", "MTMR6", "MTOR", "MYH10", "MYH9", "MYL6", "NENF", "NIP7", "NLN", "NOL10", "NPEPPS", "NSD2", "NSFL1C", "NUCB2", "NUP155", "NUP50", "OLA1", "P3H1", "PABPC1", "PABPC4", "PAIP2", "PANK4", "PFAS", "PGRMC2", "PITHD1", "PLD3", "POLR2B", "POLR2C", "PPAT", "PPM1G", "PRDX2", "PRDX3", "PRDX4", "PREP", "PRPF40A", "PSMA6", "PSMD6", "PSME2", "PTCD1", "PTGES2", "PTPN11", "PUF60", "QKI", "RANBP2", "RANBP3", "RBM10", "RBM14", "RBM3", "RBM4", "RBM5", "RBMX", "RCN2", "REPS1", "RHOT1", "RNF14", "RNF20", "RPS10", "RTN3", "SDHB", "SEC16A", "SEC24A", "SEPHS1", "SETD2", "SLC16A1", "SMN1*", "SMNDC1", "SNX5", "SPART", "SQSTM1", "SRSF9", "STAM", "SUCLG1", "SUCLG2", "SYNCRIP", "TAB1", "TAF15", "TARS2", "TBC1D9B", "TFRC", "THOP1", "TIA1", "TIAL1", "TIMM50", "TP53BP1", "TRA2B", "TRIM21", "TRIM24", "TRIM25", "TRUB1", "TUBB", "TUBB2B", "TXNDC12", "UNC119B", "USP24", "USP28", "USP33", "USP47", "VIM", "YBX3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAZ", "ZADH2", "ZC3H18", "ZC3H7A"]} \ No newline at end of file diff --git a/interpro_family/advanced/idx2term.json b/interpro_family/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..cf1055ec529245b750ed79c477a9951fd7878bb0 --- /dev/null +++ b/interpro_family/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Proteasome, subunit alpha/beta [IPR001353]", "1": "Proteasome B-type subunit [IPR023333]"} \ No newline at end of file diff --git a/interpro_family/advanced/plot_0.png b/interpro_family/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..a2c35541ef7b7475af800197d00a1a6d4eceff0b --- /dev/null +++ b/interpro_family/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:db663e856c67ba89c63a4f3783211bc8d752f31b5dbc252a3c1a7b397f050be6 +size 188938 diff --git a/interpro_family/advanced/plot_1.png b/interpro_family/advanced/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..a3ebd6666c41bc37a04a0c0d7c6dfeff29579a47 --- /dev/null +++ b/interpro_family/advanced/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:a36bf4ca3205942260e29242c4c3f67e6a26193a827e4dfbf52e51f009848f0b +size 181392 diff --git a/interpro_family/basic/idx2term.json b/interpro_family/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..e50f9cf04b133d67c4976318f44069592db48bd0 --- /dev/null +++ b/interpro_family/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Proteasome, subunit alpha/beta [IPR001353]", "1": "Proteasome B-type subunit [IPR023333]", "2": "14-3-3 protein [IPR000308]"} \ No newline at end of file diff --git a/interpro_family/basic/plot_0.png b/interpro_family/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..3863070835188611c243c454afa520f579679abc --- /dev/null +++ b/interpro_family/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:503084774a79bb1c92e4931cd58f84d3b2c130e37a401eed64a84ed0f3dd8136 +size 145156 diff --git a/interpro_family/basic/plot_1.png b/interpro_family/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..f9cd91a0c446ce2590edfe139a8290e71c4aee80 --- /dev/null +++ b/interpro_family/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:e1d829a91f6130dca9018527ddfeff657faeaa4c5e8669763424f7c797d00305 +size 139186 diff --git a/interpro_family/basic/plot_2.png b/interpro_family/basic/plot_2.png new file mode 100644 index 0000000000000000000000000000000000000000..5e6e044030c51d8a18c91af4b5aa692a7666c8c9 --- /dev/null +++ b/interpro_family/basic/plot_2.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:37780b00089369673bc2ca8834cabfc5d1da11d0cfc5c161ea8a0e53e080471d +size 134162 diff --git a/interpro_family/consensus.joblib b/interpro_family/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..b0838a608b33efe67fcaf45ed652f3911be21264 --- /dev/null +++ b/interpro_family/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:469f4e8ca2e168a1bca78f36fa072b1e41035266747dbbecbe8149724a5ba83c +size 368837 diff --git a/interpro_family/df_merge.tsv b/interpro_family/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..29794e47bdf9cedafba6973571e1798903fc29db --- /dev/null +++ b/interpro_family/df_merge.tsv @@ -0,0 +1,6 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Proteasome, subunit alpha/beta [IPR001353] 8 14 3.0112103869242937 0.0026020849349044 5.075242718446602 13.970873786407768 1.2284854682369022 0.3020132543529001 2.3027355385508845 0.1681602725795027 1.1101966392985694 0.3179790146746512 0.0001627882362757 0.0027067874988798 0.000440337804097 4.154092917887778e-08 1.1762659477401498e-08 +Proteasome B-type subunit [IPR023333] 6 7 2.5190972052463905 0.0117656170503701 3.699029126213592 6.970873786407767 1.6670727234653664 0.1509307531330224 1.4503762582219135 0.1681602725795027 0.9611878160538336 0.233503072382129 2.527574560795007e-05 0.0008300469730069 6.936272072908627e-05 1.4679347449836997e-08 2.017181679879996e-08 +Major facilitator superfamily [IPR011701] 4 6 2.3578752183459444 0.0183798699979977 1.900485436893204 4.145631067961165 1.0239318262629833 0.2378354197978781 1.3191273068698348 1.552684909115802 1.329586452483978 0.2573287434106264 1.951557787083355e-05 0.0002088865488349 7.357256485958134e-05 0.0024022577840735 0.0052134507581354 +Importin subunit alpha [IPR024931] 3 5 2.148923203572935 0.0316404881232532 1.900485436893204 4.162621359223301 -0.0859723492776628 0.5961263336607893 1.2157141643493203 0.6792778306365289 0.8334835296312452 0.3002751483750439 6.1078318265291925e-06 2.196659839709844e-06 1.6865595784317113e-05 4.77609685109951e-06 7.614857799780336e-05 +Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930] 4 6 2.0492681978473724 0.0404358966063769 2.121359223300971 5.466019417475728 1.4317001483019938 0.1783942022754649 1.021530403905949 0.5881604361499402 0.986353205880356 0.2226891741813114 0.053639682462237 0.0385773062479974 0.0743799864466655 0.1775366954381628 1.3106068439724131e-05 diff --git a/interpro_family/metrics.json b/interpro_family/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..5eee36f30e1ff4bf3f366186f2843b92d45bed32 --- /dev/null +++ b/interpro_family/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2812, + "annotations_size": 2191, + "title": "Average number of proteins per term", + "value": 1.2752167959835692 +} \ No newline at end of file diff --git a/interpro_family/paths.json b/interpro_family/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..430f5ae8f3ac4ad87d16db067a8d4e58f2cba1be --- /dev/null +++ b/interpro_family/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_family/fragment/C428/C428_val_log2fc"} \ No newline at end of file diff --git a/interpro_family/result.tsv b/interpro_family/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..d56a73706371463e6cd3b4e5a021c0b66165b1a5 --- /dev/null +++ b/interpro_family/result.tsv @@ -0,0 +1,93 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Proteasome, subunit alpha/beta [IPR001353] 0.8180527225900656 3.0112103869242937 0.0026020849349044 0.9966826813124348 0.0645007858878832 14 P25788,P28074,P20618,Q99436,P28072,P28070,P49721,P60900 8 +Proteasome B-type subunit [IPR023333] 0.8894830659536515 2.5190972052463905 0.0117656170503701 0.9999999999945276 0.0741941558991024 7 P28074,P20618,Q99436,P28072,P28070,P49721 6 +Major facilitator superfamily [IPR011701] 0.896118265090871 2.3578752183459444 0.0183798699979977 1.0 0.0883120508017832 6 P53985,Q96ES6,Q8NHS3,Q5SR56 4 +Importin subunit alpha [IPR024931] 0.9176634815703018 2.148923203572935 0.0316404881232532 1.0 0.1150761469922452 5 O00505,O00629,P52294 3 +Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930] 0.8212779723845033 2.0492681978473724 0.0404358966063769 1.0 0.1315967957124069 6 Q9UIQ6,P55786,P09960,Q6P179 4 +Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678] 0.997153024911032 1.9423406507791925 0.0520958749302404 1.0 0.1505831952139273 2 Q99595 1 +Palmitoyl protein thioesterase [IPR002472] 0.9761565836298932 1.857124040148327 0.0632935086979604 1.0 0.1700633759773565 2 Q9UMR5 1 +Transmembrane protein GPR107/GPR108-like [IPR009637] 0.9750889679715296 1.8527802640509752 0.063913860128145 1.0 0.1711922586072931 2 Q9NPR9 1 +Haem oxygenase-like [IPR016053] 0.972241992882564 1.841192043332856 0.0655934209443853 1.0 0.1729424612384456 2 P30519 1 +Haem oxygenase [IPR002051] 0.972241992882564 1.841192043332856 0.0655934209443853 1.0 0.1729424612384456 2 P30519 1 +CD36 family [IPR002159] 0.9704626334519588 1.8339458930637749 0.066662026223736 1.0 0.1738767850669116 2 Q8WTV0 1 +Eukaryotic porin/Tom40 [IPR027246] 0.9293773072791828 1.7720992315477286 0.0763780864960761 1.0 0.1891592345886382 4 P21796 1 +Isocitrate dehydrogenase NADP-dependent [IPR004790] 0.95266903914591 1.7613439310148524 0.0781802087577281 1.0 0.192680357017078 2 P48735 1 +Glycoside hydrolase, family 35 [IPR001944] 0.9434163701067636 1.7234980663625985 0.0847984945480808 1.0 0.2021692073502123 2 Q8IW92 1 +Beta-galactosidase 1-like [IPR026283] 0.9434163701067636 1.7234980663625985 0.0847984945480808 1.0 0.2021692073502123 2 Q8IW92 1 +ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028] 0.9395017793594352 1.7074691549815038 0.087734886174839 1.0 0.2062522914260433 2 Q9Y487 1 +V-type ATPase, V0 complex, 116kDa subunit family [IPR002490] 0.9395017793594352 1.7074691549815038 0.087734886174839 1.0 0.2062522914260433 2 Q9Y487 1 +Mitochondrial carrier UCP-like [IPR002030] 0.933451957295378 1.6826786005896974 0.0924373265278912 1.0 0.2114093762240185 2 Q9H2D1 1 +HnRNP R/Q splicing factor [IPR006535] 0.9245551601423484 1.6461843605536597 0.0997258081500418 1.0 0.2220520789194529 2 O60506 1 +Histidine phosphatase superfamily, clade-2 [IPR000560] 0.8928825622775785 1.5159951898078918 0.1295205687158602 1.0 0.2627588574596757 2 P11117 1 +Ancient conserved domain protein family [IPR045095] 0.8896797153024895 1.5028150005660998 0.1328867566133942 1.0 0.266709566126862 2 Q8NE01 1 +Aminopeptidase N-type [IPR034016] 0.8486467236467139 1.4655954367685229 0.1427585351731908 1.0 0.2787735744781293 4 Q9UIQ6,P55786,Q6P179 3 +Porin, eukaryotic type [IPR001925] 0.93956568964986 1.4525285749070125 0.1463546897672571 1.0 0.2826651604918689 3 P21796 1 +Peptidase T1A, proteasome beta-subunit [IPR000243] 0.9298682805268826 1.41694785721155 0.1564981730127224 1.0 0.2960632230703841 3 P28072,P28074 2 +Glycoside hydrolase, family 29 [IPR000933] 0.8594306049822151 1.378332726868318 0.1681005832940041 1.0 0.3074360417338589 2 Q9BTY2 1 +Alpha-L-fucosidase, metazoa-type [IPR016286] 0.8594306049822151 1.378332726868318 0.1681005832940041 1.0 0.3074360417338589 2 Q9BTY2 1 +Profilin1/2/3, vertebrate [IPR005454] 0.8558718861209968 1.3636977697953243 0.1726627062654804 1.0 0.3136849000229416 2 P35080 1 +Profilin [IPR005455] 0.8558718861209968 1.3636977697953243 0.1726627062654804 1.0 0.3136849000229416 2 P35080 1 +Polyadenylate binding protein, human types 1, 2, 3, 4 [IPR006515] 0.8508896797153012 1.3432165420477604 0.1792018667873742 1.0 0.3223573810600468 2 Q13310 1 +Peptidase S10, serine carboxypeptidase [IPR001563] 0.907636865836474 1.335365276180793 0.1817568237829161 1.0 0.3250850619660156 3 Q9HB40 1 +Tubulin [IPR000217] 0.8063443746058448 1.3035067198458916 0.1924018237166755 1.0 0.338324555187188 4 Q9BVA1,P07437 2 +Beta tubulin [IPR002453] 0.8063443746058448 1.3035067198458916 0.1924018237166755 1.0 0.338324555187188 4 Q9BVA1,P07437 2 +Acyl-CoA oxidase [IPR012258] 0.8373665480427062 1.2876854558604762 0.1978554784113486 1.0 0.3443219644156194 2 O15254 1 +Peroxisomal acyl-coenzyme A oxidase [IPR034171] 0.8373665480427062 1.2876854558604762 0.1978554784113486 1.0 0.3443219644156194 2 O15254 1 +A-kinase anchoring protein 95 (AKAP95) [IPR007071] 0.8935564257743009 1.2837262281210593 0.199237763939132 1.0 0.3461775898419019 3 Q9ULX6,O43823 2 +TAF15/EWS/TLS family [IPR034870] 0.8750444998220077 1.2159385803374958 0.224008319950874 1.0 0.3718179821226387 3 P35637,Q92804 2 +Fragile X mental retardation syndrome-related protein [IPR040148] 0.8743325026699966 1.2133347167636144 0.2250018748299735 1.0 0.3721851487603574 3 P51116,P51114 2 +Glutathione Transferase family [IPR040079] 0.5449643903954923 1.182114893256054 0.2371601156978118 1.0 0.3851874080755416 10 Q13505,Q9H7Z7,P21266 3 +Sorting nexin-5/6/32 [IPR014637] 0.7879003558718842 1.0859997276062054 0.2774791127586744 1.0 0.4239586722833024 2 Q9Y5X3 1 +Proteasome alpha-type subunit [IPR023332] 0.5695943914393442 1.0780240648467938 0.2810230168778727 1.0 0.4272875988753775 7 P60900 1 +Microtubule-associated protein RP/EB [IPR027328] 0.7765124555160293 1.040082592236118 0.2983015304518219 1.0 0.4455205543421554 2 Q15555 1 +Prefoldin alpha-like [IPR004127] 0.7725978647686809 1.0243598032856094 0.3056653606638373 1.0 0.4537349628824306 2 P61758 1 +Protein arginine N-methyltransferase [IPR025799] 0.7288745758232646 1.0074654158567469 0.3137111691878633 1.0 0.4609934082431983 4 Q99873,Q86X55 2 +Calponin/LIMCH1 [IPR001997] 0.7661921708185065 0.9987061936104892 0.3179370394449743 1.0 0.4659532129926011 2 Q15417 1 +Alanine-tRNA ligase, eukaryota/bacteria [IPR023033] 0.7601423487544646 0.9745691334738243 0.329774030785475 1.0 0.4766061355217519 2 Q5JTZ9 1 +Alanine-tRNA ligase, class IIc [IPR002318] 0.7601423487544646 0.9745691334738243 0.329774030785475 1.0 0.4766061355217519 2 Q5JTZ9 1 +S-phase kinase-associated protein 1-like [IPR001232] 0.7569395017793746 0.961829074965588 0.3361354704491568 1.0 0.4823004687322217 2 Q15369 1 +La domain containing protein [IPR045180] 0.5845653087203403 0.7951365864499644 0.4265340543995344 1.0 0.5619579754596391 5 Q71RC2,Q92615,Q4G0J3 3 +Copper chaperone SCO1/SenC [IPR003782] 0.6818505338078287 0.673803060769697 0.5004365286751207 1.0 0.618418744685386 2 O43819 1 +Synthesis of cytochrome c oxidase, Sco1/Sco2 [IPR017276] 0.6818505338078287 0.673803060769697 0.5004365286751207 1.0 0.618418744685386 2 O43819 1 +Flotillin family [IPR027705] 0.6814946619217083 0.6725013308301312 0.5012645931759925 1.0 0.6190814341522188 2 Q14254 1 +Cleft lip and palate transmembrane protein 1-like protein [IPR030434] 0.6701067615658347 0.6312517183434923 0.5278759505715191 1.0 0.636926447533482 2 Q96KA5 1 +Cleft lip and palate transmembrane 1 [IPR008429] 0.6701067615658347 0.6312517183434923 0.5278759505715191 1.0 0.636926447533482 2 Q96KA5 1 +Prefoldin beta-like [IPR002777] 0.7012573298576119 0.6063161782801125 0.5443048175633227 1.0 0.6467863314463104 3 O15212 1 +Peptidase M3A/M3B [IPR045090] 0.7009611961552226 0.6053604860685285 0.5449394998182422 1.0 0.6467863314463104 3 P52888,Q9BYT8 2 +Proteasome activator PA28 [IPR009077] 0.6986471175756438 0.5979079432511784 0.549901359461868 1.0 0.6488066120522094 3 Q9UL46 1 +Peptidase S9A, prolyl oligopeptidase [IPR002470] 0.6576512455515993 0.5870980581418421 0.5571378516763432 1.0 0.6531241482198331 2 P48147 1 +Annexin [IPR001464] 0.4481152811367704 0.5219084417124175 0.601734080403064 1.0 0.6766201349590958 7 P50995,P04083 2 +Tumour protein D52 [IPR007327] 0.6380782918149435 0.5199901094802385 0.6030704686558277 1.0 0.6772148942891059 2 O43399 1 +KH domain-containing BBP-like [IPR045071] 0.5671486044579115 0.4346269761702772 0.663833210925473 1.0 0.7091460580876213 4 Q07666,O75525 2 +14-3-3 protein [IPR000308] 0.4354953670705573 0.3889432256894514 0.6973181452731891 1.0 0.7370111221869549 6 P31946,P61981,P62258,P63104,Q04917 5 +Exosome complex RNA-binding protein 1/RRP40/RRP4 [IPR026699] 0.5950177935943003 0.3840342891064064 0.700953033458563 1.0 0.7390703062116032 2 Q13868 1 +Glycogen/starch/alpha-glucan phosphorylase [IPR011833] 0.5914590747330902 0.3736200512772922 0.7086870138387349 1.0 0.7447161857653084 2 P06737 1 +Glycosyl transferase, family 35 [IPR000811] 0.5914590747330902 0.3736200512772922 0.7086870138387349 1.0 0.7447161857653084 2 P06737 1 +Nucleosome assembly protein (NAP) [IPR002164] 0.5374789693136626 0.3456736325653735 0.7295880022243684 1.0 0.763384581123969 4 Q99733,P55209 2 +Monothiol glutaredoxin-related [IPR004480] 0.5701067615658293 0.3140959095354865 0.7534481961618609 1.0 0.786846996087053 2 Q86SX6 1 +26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 [IPR019585] 0.566192170818498 0.3037575445393421 0.7613126138079509 1.0 0.7931697274623017 2 Q15008 1 +Cyclin [IPR039361] 0.498932384341627 0.156761866877834 0.8754325270320047 1.0 0.9026646765212804 2 P14635 1 +Mitochondrial Rho GTPase [IPR021181] 0.4900355871886024 0.1418490469391789 0.8871992418738401 1.0 0.9130359506555114 2 Q8IXI2 1 +Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7 [IPR045237] 0.4896797153024814 0.1412747663130263 0.8876528832292383 1.0 0.9130739282419066 2 Q9H9Q2 1 +ClpA/B family [IPR001270] 0.4886120996441275 0.1395621522393451 0.8890059460204724 1.0 0.9140366155470928 2 Q15645 1 +THRAP3/BCLAF1 family [IPR029199] 0.486476868327399 0.1361828854318319 0.8916767045618945 1.0 0.9163525608326036 2 Q9Y2W1 1 +Heterogeneous nuclear ribonucleoprotein C [IPR017347] 0.4857651245551535 0.1350700591751802 0.8925564825260386 1.0 0.9168266541090252 2 P07910 1 +Fumarate lyase family [IPR000362] 0.4765124555160116 0.1212182236464325 0.9035181901715184 1.0 0.9259159750541612 2 P07954 1 +Ras GTPase-activating protein-binding protein [IPR039539] 0.4604982206405713 0.0998956579457909 0.9204271635664204 1.0 0.9410433576173716 2 Q9UN86 1 +Dynamin [IPR022812] 0.481310074759695 0.0896304854393414 0.9285808580219956 1.0 0.9479324144213862 3 O00429,P50570 2 +Ribonuclease CAF1 [IPR006941] 0.4384341637010643 0.0757720667533993 0.9396004397202056 1.0 0.9575184015939396 2 Q9UIV1 1 +HnRNP-L/PTB [IPR006536] 0.4355871886120964 0.0730791295806138 0.9417431494261104 1.0 0.9586320754346614 2 P14866 1 +Threonine-tRNA ligase, class IIa [IPR002320] 0.4352313167259776 0.0727489833087745 0.9420058687406784 1.0 0.9586320754346614 2 Q9BW92 1 +Aspartyl/Asparaginyl-tRNA synthetase, class IIb [IPR002312] 0.4574581701673237 0.0632603576884942 0.9495591824874428 1.0 0.9640797816635714 3 O43776,Q6PI48 2 +Derlin [IPR007599] 0.3911032028469764 0.0418957130935224 0.9665818338550564 1.0 0.9800003692625768 2 Q9BUN8 1 +High mobility group protein HMGA [IPR000116] 0.3807829181494704 0.0371839121405647 0.9703383659936112 1.0 0.9833540055004636 2 P52926 1 +Taxilin family [IPR026183] 0.3761565836298975 0.0353264458939185 0.9718194357141487 1.0 0.9842338104058602 2 Q9NUQ3 1 +FAM98 [IPR018797] 0.3555160142348811 0.0287159705480315 0.9770911189649923 1.0 0.9873406109415288 2 Q52LJ0 1 +Dynein 1 light intermediate chain [IPR008467] 0.3487544483985818 0.0270701096662061 0.978403815051376 1.0 0.9873406109415288 2 O43237 1 +Dynein family light intermediate chain [IPR022780] 0.3487544483985818 0.0270701096662061 0.978403815051376 1.0 0.9873406109415288 2 O43237 1 +Ribosomal protein S5/S7 [IPR000235] 0.3227758007117504 0.0225894229249594 0.9819777809595094 1.0 0.9892015255550736 2 Q9Y2R9 1 +Protein phosphatase 2C family [IPR015655] 0.3645467173177931 0.0214899558567693 0.982854815679406 1.0 0.9896300097213138 4 O15355,Q15750 2 +Ran binding protein RanBP1-like [IPR045255] 0.3596866096866112 0.0175537005267803 0.9859948926063156 1.0 0.991424878247103 4 Q9H6Z4,P49792,Q9UKX7 3 +Pre-mRNA-splicing factor Syf1-like [IPR045075] 0.3837664649341453 0.0148493369805385 0.9881523786922984 1.0 0.9926831094520064 3 Q9HCS7,Q9BZJ0 2 +DNA mismatch repair MutS family [IPR045076] 0.3616945532217912 0.0078224083248476 0.9937586848204608 1.0 0.9974004940181536 3 P43246,P52701 2 +Cell-cycle alteration and expression-elevated protein in tumour [IPR032337] 0.3527945888216461 0.0056778021527153 0.995469793663442 1.0 0.998660401976466 3 Q9NQG5,Q96P16 2 diff --git a/interpro_family/selections.json b/interpro_family/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..4781ef11df1910c3aef6005d1dfe8a09647815f3 --- /dev/null +++ b/interpro_family/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["(Uracil-5)-methyltransferase family [IPR010280]", "-alpha-acetyltransferase 35, NatC auxiliary subunit [IPR007244]", "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, eukaryotes [IPR027496]", "1-Cys peroxiredoxin [IPR045020]", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [IPR028380]", "14-3-3 protein [IPR000308]", "14-3-3 theta [IPR042584]", "16S/18S rRNA aminocarboxypropyltransferase Tsr3 [IPR022968]", "2-amino-3-ketobutyrate coenzyme A ligase [IPR011282]", "2-deoxynucleoside 5-phosphate N-hydrolase 1, DNPH1 [IPR028607]", "2-oxoglutarate dehydrogenase E1 component [IPR011603]", "2-phosphoglycolate phosphatase, eukaryotic [IPR006349]", "26S Proteasome non-ATPase regulatory subunit 1 [IPR035266]", "26S Proteasome non-ATPase regulatory subunit 11 [IPR035295]", "26S Proteasome non-ATPase regulatory subunit 12 [IPR035297]", "26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4 [IPR040134]", "26S Proteasome non-ATPase regulatory subunit 13 [IPR035298]", "26S Proteasome non-ATPase regulatory subunit 14 [IPR035299]", "26S Proteasome non-ATPase regulatory subunit 6 [IPR035268]", "26S Proteasome non-ATPase regulatory subunit 7/8 [IPR033858]", "26S Proteasome regulatory subunit 4 [IPR035244]", "26S Proteasome regulatory subunit 6A [IPR035254]", "26S Proteasome regulatory subunit 6B [IPR035256]", "26S Proteasome regulatory subunit 7 [IPR035245]", "26S proteasome non-ATPase regulatory subunit 10-like [IPR039334]", "26S proteasome non-ATPase regulatory subunit 3 [IPR035267]", "26S proteasome non-ATPase regulatory subunit Rpn12 [IPR006746]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit [IPR016643]", "26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit [IPR016642]", "26S proteasome regulatory subunit 10B [IPR035263]", "26S proteasome regulatory subunit P45-like [IPR005937]", "26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 [IPR019585]", "28S ribosomal protein S17, mitochondrial [IPR039193]", "28S ribosomal protein S25, mitochondrial [IPR040049]", "28S ribosomal protein S27, mitochondrial [IPR019266]", "28kDa heat- and acid-stable phosphoprotein [IPR039876]", "3'-5' RNA helicase YTHDC2-like [IPR031083]", "3-hydroxyacyl-CoA dehydrogenase [IPR022694]", "3-hydroxyisobutyrate dehydrogenase [IPR011548]", "3-hydroxyisobutyrate dehydrogenase-related [IPR015815]", "3-ketodihydrosphingosine reductase KDSR-like [IPR045022]", "3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase [IPR039357]", "3-oxoacid CoA-transferase [IPR014388]", "39S ribosomal protein L40, mitochondrial [IPR039145]", "39S ribosomal protein L43/54S ribosomal protein L51 [IPR039927]", "40S Ribosomal protein S10 [IPR037447]", "40S ribosomal protein S1/3, eukaryotes [IPR027500]", "40S ribosomal protein SA [IPR027504]", "4F2 cell-surface antigen heavy chain [IPR042280]", "5'-3' exoribonuclease 1 [IPR016494]", "5'-3' exoribonuclease [IPR027073]", "5'-3' exoribonuclease type 2 [IPR017151]", "5'-AMP-activated protein kinase subunit gamma-1 [IPR039166]", "5-formyltetrahydrofolate cyclo-ligase [IPR002698]", "50S ribosomal protein L18Ae/60S ribosomal protein L20 and L18a [IPR028877]", "6-Phosphogluconolactonase [IPR039104]", "6-phosphogluconate dehydrogenase [IPR006183]", "6-phosphogluconate dehydrogenase, decarboxylating [IPR006113]", "60S acidic ribosomal protein P0 [IPR030670]", "60S ribosomal protein L18a/ L20, eukaryotes [IPR021138]", "60S ribosomal protein L19 [IPR039547]", "60S ribosomal protein L35 [IPR045059]", "60S ribosomal protein L6E [IPR000915]", "60kDa SS-A/Ro ribonucleoprotein [IPR040322]", "A-kinase anchor protein 12 [IPR028540]", "A-kinase anchoring protein 95 (AKAP95) [IPR007071]", "A1 cistron-splicing factor, AAR2 [IPR007946]", "AAA ATPase, CDC48 family [IPR005938]", "ADF/Cofilin [IPR017904]", "ADP-ribose pyrophosphatase, mitochondrial [IPR039989]", "ADP-ribosylation factor 1-5 [IPR045872]", "ADP-ribosylation factor-like protein 2 [IPR045873]", "ADP-ribosylation factor-like protein 2/3 [IPR044612]", "ADP-ribosylation factor-like protein 6 [IPR041839]", "ADP-ribosylation factor-like protein 6-interacting protein 1 [IPR033301]", "ADP-ribosylation factor-like protein 8A/8B [IPR044154]", "ADP-specific phosphofructokinase/glucokinase [IPR007666]", "ADP/ATP carrier protein, eukaryotic type [IPR002113]", "AH receptor-interacting protein [IPR031208]", "AIP/AIPL1 [IPR039663]", "AMP deaminase 2 [IPR029749]", "AMP deaminase [IPR006329]", "AP complex subunit beta [IPR026739]", "AP endonuclease 1 [IPR004808]", "AP-1/2/4 complex subunit beta [IPR016342]", "AP-2 complex subunit sigma [IPR027156]", "AP-3 complex subunit beta [IPR026740]", "AP-3 complex subunit sigma [IPR027155]", "ARMET-like [IPR045333]", "AT-rich interactive domain-containing protein 3 [IPR045147]", "ATP synthase membrane subunit K [IPR009125]", "ATP synthase, F0 complex, subunit B [IPR013837]", "ATP synthase, F0 complex, subunit B/MI25 [IPR008688]", "ATP synthase, F0 complex, subunit D, mitochondrial [IPR008689]", "ATP synthase, F0 complex, subunit E, mitochondrial [IPR008386]", "ATP synthase, F0 complex, subunit G, mitochondrial [IPR006808]", "ATP synthase, F1 complex, alpha subunit [IPR005294]", "ATP synthase, F1 complex, beta subunit [IPR005722]", "ATP synthase, F1 complex, gamma subunit [IPR000131]", "ATP-citrate synthase [IPR014608]", "ATP-dependent 6-phosphofructokinase [IPR022953]", "ATP-dependent 6-phosphofructokinase, eukaryotic-type [IPR009161]", "ATP-dependent 6-phosphofructokinase, vertebrate-type [IPR041914]", "ATP-dependent Clp protease proteolytic subunit [IPR001907]", "ATP-dependent RNA helicase DHX29 [IPR034730]", "ATP-dependent RNA helicase Ski2-like [IPR016438]", "ATP-dependent helicase Rad3/Chl1-like [IPR013020]", "ATP11 [IPR010591]", "ATP:guanido phosphotransferase [IPR000749]", "ATPase family AAA domain-containing protein 2 [IPR031252]", "ATPase family AAA domain-containing protein 3 [IPR039188]", "ATPase family AAA domain-containing protein ATAD2-like [IPR045199]", "ATPase, OSCP/delta subunit [IPR000711]", "ATPase, V0 complex, c/d subunit [IPR002843]", "ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028]", "ATPase, V0 complex, subunit d [IPR016727]", "ATPase, V1 complex, subunit A [IPR005725]", "ATPase, V1 complex, subunit B [IPR005723]", "ATPase, V1 complex, subunit C [IPR004907]", "ATPase, V1 complex, subunit D [IPR002699]", "ATPase, V1 complex, subunit H [IPR004908]", "ATPase, vacuolar ER assembly factor, Vma12 [IPR021013]", "Acetoacetyl-CoA synthase [IPR005914]", "Acid ceramidase-like [IPR016699]", "Acidic leucine-rich nuclear phosphoprotein 32 [IPR045081]", "Acireductone dioxygenase ARD family [IPR004313]", "Aconitase, mitochondrial-like [IPR006248]", "Aconitase/Iron-responsive element-binding protein 2 [IPR006249]", "Actin family [IPR004000]", "Actin-related protein 10 [IPR027127]", "Actin-related protein 2/3 complex subunit 1 [IPR017383]", "Actin-related protein 2/3 complex subunit 1A [IPR030140]", "Actin-related protein 2/3 complex subunit 2 [IPR007188]", "Actin-related protein 2/3 complex subunit 3 [IPR007204]", "Actin-related protein 2/3 complex subunit 4 [IPR008384]", "Actin-related protein 3 [IPR015623]", "Activating signal cointegrator 1 complex subunit 1 [IPR009210]", "Activating signal cointegrator 1-like [IPR039128]", "Activator of 90kDa heat shock protein ATPase-like [IPR039981]", "Activator of Hsp90 ATPase homologue 1-like [IPR013538]", "Active zone protein ELKS [IPR019323]", "Activity-dependent neuroprotector homeobox protein [IPR038861]", "Acyl-CoA desaturase [IPR015876]", "Acyl-CoA oxidase [IPR012258]", "Acyl-CoA thioesterase [IPR003703]", "Acyl-CoA-binding domain-containing protein 5 [IPR016347]", "Acyl-coenzyme A thioesterase 13 [IPR039298]", "Acylneuraminate cytidylyltransferase [IPR003329]", "Acyltransferase ChoActase/COT/CPT [IPR000542]", "Adaptor protein complex AP-1, gamma subunit [IPR017107]", "Adaptor protein complex AP-2, alpha subunit [IPR017104]", "Adaptor protein complex AP-3, delta subunit [IPR017105]", "Adaptor protein complex, sigma subunit [IPR016635]", "Adenine phosphoribosyl transferase [IPR005764]", "Adenosine kinase [IPR001805]", "Adenosylhomocysteinase-like [IPR000043]", "Adenylate cyclase-associated CAP [IPR001837]", "Adenylate kinase 2 [IPR028587]", "Adenylate kinase 3/4, mitochondrial [IPR028586]", "Adenylate kinase isoenzyme 1 [IPR028582]", "Adenylate kinase isoenzyme 6 [IPR020618]", "Adenylate kinase subfamily [IPR006259]", "Adenylate kinase, isozyme 1/5 [IPR006267]", "Adenylate kinase/UMP-CMP kinase [IPR000850]", "Adenylosuccinate lyase [IPR004769]", "Adenylosuccinate synthetase [IPR001114]", "Adenylosuccinate synthetase isozyme 2, chordates [IPR027529]", "Adenylyl cyclase-associated protein CAP1 [IPR028415]", "Adenylyl-sulfate kinase [IPR002891]", "AdoMet-dependent rRNA methyltransferase Spb1-like [IPR028589]", "Aladin [IPR045139]", "Alanine-tRNA ligase, class IIc [IPR002318]", "Alanine-tRNA ligase, eukaryota/bacteria [IPR023033]", "Alcohol dehydrogenase class III [IPR014183]", "Aldehyde dehydrogenase NAD(P)-dependent [IPR012394]", "Aldehyde dehydrogenase family 7 member A1-like [IPR044638]", "Aldo-keto reductase [IPR020471]", "Aldo-keto reductase family 1 member A1 [IPR044481]", "Aldose 1-/Glucose-6-phosphate 1-epimerase [IPR008183]", "Aldose 1-epimerase [IPR015443]", "Alkyldihydroxyacetonephosphate synthase [IPR025650]", "Alpha E-catenin/Alpha T-catenin [IPR030047]", "Alpha crystallin/Small heat shock protein, animal type [IPR001436]", "Alpha-2-macroglobulin receptor-associated protein [IPR038003]", "Alpha-D-phosphohexomutase superfamily [IPR005841]", "Alpha-L-fucosidase, metazoa-type [IPR016286]", "Alpha-N-acetylglucosaminidase [IPR007781]", "Alpha-N-methyltransferase NTM1 [IPR008576]", "Alpha-adducin [IPR027766]", "Alpha-catenin [IPR001033]", "Alpha-ketoglutarate-dependent dioxygenase FTO [IPR032868]", "Amidophosphoribosyltransferase [IPR005854]", "Amino acid/polyamine transporter I [IPR002293]", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 [IPR042360]", "Aminoacyl-tRNA synthetase, class Ic [IPR002305]", "Aminopeptidase N-type [IPR034016]", "Aminopeptidase, leukotriene A4 hydrolase-like [IPR034015]", "Aminotransferase class-III [IPR005814]", "AmpG-like permease/Acetyl-coenzyme A transporter 1 [IPR004752]", "Amyloidogenic glycoprotein [IPR008155]", "Anamorsin [IPR007785]", "Anaphase-promoting complex subunit 1 [IPR024990]", "Anaphase-promoting complex subunit 16 [IPR029641]", "Anaphase-promoting complex subunit 2 [IPR044554]", "Anaphase-promoting complex subunit 5 [IPR037679]", "Ancient conserved domain protein family [IPR045095]", "Angiomotin [IPR009114]", "Ankycorbin [IPR042420]", "Ankyrin repeat and LEM domain-containing protein 2 [IPR035007]", "Annexin A1 [IPR002388]", "Annexin A11 [IPR008157]", "Annexin A2 [IPR002389]", "Annexin A3 [IPR002390]", "Annexin A4 [IPR002391]", "Annexin A6 [IPR002393]", "Annexin [IPR001464]", "Anoctamin [IPR007632]", "Anoctamin-6 [IPR031295]", "Antifreeze, type III [IPR006013]", "Apolipoprotein L [IPR008405]", "Apoptosis inhibitory 5 [IPR008383]", "Apoptosis regulator, Mcl-1 [IPR013281]", "Arfaptin family [IPR030798]", "Arfaptin-1 [IPR030793]", "Arginase [IPR014033]", "Arginine-tRNA ligase [IPR001278]", "Armadillo repeat-containing protein 6 [IPR040104]", "Arsenical pump ATPase, ArsA/GET3 [IPR016300]", "Arsenical pump ATPase, ArsA/GET3, eukaryotic [IPR027542]", "Arylesterase [IPR002640]", "Ashwin [IPR024887]", "Asparagine synthase, glutamine-hydrolyzing [IPR006426]", "Asparagine-tRNA ligase [IPR004522]", "Aspartate carbamoyltransferase [IPR002082]", "Aspartate-tRNA ligase, type 1 [IPR004524]", "Aspartate-tRNA synthetase, type 2 [IPR004523]", "Aspartate/ornithine carbamoyltransferase [IPR006130]", "Aspartate/other aminotransferase [IPR000796]", "Aspartyl/Asparaginyl-tRNA synthetase, class IIb [IPR002312]", "Aspartyl/asparaginyl beta-hydroxylase family [IPR039038]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit [IPR004413]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, subunit B /E [IPR017959]", "Associate of Myc 1 [IPR026060]", "Ataxin2-like [IPR045117]", "Atypical dual specificity phosphatase, subfamily A [IPR020405]", "Autophagy protein Atg8 ubiquitin-like [IPR004241]", "Autophagy-related protein 9 [IPR007241]", "B-cell receptor-associated protein 29/31 [IPR008417]", "BBP/SF1 family [IPR031150]", "BCP1 family [IPR025602]", "BRCA1-A complex subunit BRE [IPR010358]", "BRI3-binding protein [IPR033367]", "Bacterial/eukaryotic lysine-tRNA ligase, class II [IPR034762]", "Baculoviral IAP repeat-containing protein 6 [IPR022103]", "Band 4.1 protein, chordates [IPR021187]", "Band 4.1-like protein 2 [IPR030546]", "Band 4.1-like protein 3 [IPR030691]", "Band 4.1-like protein 5 [IPR030694]", "Barrier- to-autointegration factor, BAF [IPR004122]", "Basigin [IPR044157]", "Basigin-like [IPR043204]", "Bax inhibitor 1-related [IPR006214]", "Bcl-2 family [IPR026298]", "Bcl-2-associated transcription factor 1 [IPR026668]", "Bcl-2-like protein 13 [IPR042398]", "Bcl2-like [IPR002475]", "Beta tubulin [IPR002453]", "Beta-1,4-glucuronyltransferase 1 [IPR043189]", "Beta-N-acetylglucosaminidase [IPR011496]", "Beta-catenin [IPR013284]", "Beta-catenin-like protein 1 [IPR039678]", "Beta-galactosidase 1-like [IPR026283]", "Beta-hexosaminidase [IPR025705]", "Beta-lactamase HcpB-like [IPR040239]", "Bicaudal-D protein [IPR018477]", "Bifunctional purine biosynthesis protein PurH-like [IPR002695]", "Biliverdin reductase A [IPR017094]", "Biotin--acetyl-CoA-carboxylase ligase [IPR004408]", "BolA protein [IPR002634]", "BolA-like protein 2 [IPR045115]", "Brain acid soluble protein 1 [IPR008408]", "Bud22/Serum response factor-binding protein 1 [IPR037393]", "Bystin [IPR007955]", "C-5 cytosine methyltransferase [IPR001525]", "C-terminal binding protein [IPR043322]", "CAAX prenyl protease 1 [IPR027057]", "CCR4-NOT transcription complex subunit 1 [IPR040398]", "CCR4-NOT transcription complex subunit 7 [IPR039636]", "CCR4-NOT transcription complex subunit 7/8/Pop2 [IPR039637]", "CCR4-NOT transcription complex subunit 9 [IPR007216]", "CD2 antigen cytoplasmic tail-binding protein 2/Lin1 [IPR039905]", "CD2-associated protein [IPR028445]", "CD34/Podocalyxin [IPR013836]", "CD36 family [IPR002159]", "CD36/scavenger receptor class B member 1 [IPR005428]", "CDGSH iron-sulfur domain-containing protein 1/2 [IPR045131]", "CDK5 regulatory subunit-associated protein 3 [IPR008491]", "CDP-alcohol phosphatidyltransferase [IPR000462]", "CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote [IPR014387]", "CEBPZ/Mak21-like [IPR040155]", "CGI121/TPRKB [IPR013926]", "CHORD domain containing protein [IPR039790]", "CLIP-associating protein 1 [IPR028399]", "CLU domain containing protein [IPR027523]", "COG complex component, COG2 [IPR009316]", "COMM domain-containing protein 4 [IPR037356]", "COMPASS component Swd2/WDR82 [IPR037867]", "COP9 signalosome complex subunit 1 [IPR033008]", "COP9 signalosome complex subunit 2 [IPR037750]", "COP9 signalosome complex subunit 3 [IPR037753]", "COP9 signalosome complex subunit 4 [IPR037754]", "COP9 signalosome complex subunit 5 [IPR037740]", "COP9 signalosome complex subunit 7B [IPR027530]", "COP9 signalosome subunit 6 [IPR033859]", "COP9 signalosome, subunit CSN8 [IPR033205]", "COPII coat assembly protein, Sec16 [IPR024880]", "COX15/CtaA family [IPR003780]", "CPSF6/7 family [IPR034772]", "CTP synthase [IPR004468]", "CWF11 family [IPR026300]", "CXXC motif containing zinc binding protein, eukaryotic [IPR008584]", "CYFIP-related Rac1 interactor [IPR039789]", "Cadherin [IPR039808]", "Calcium homeostasis endoplasmic reticulum protein [IPR039037]", "Calcium load-activated calcium channel [IPR008559]", "Calcium uptake protein 1/2/3 [IPR039800]", "Calcium-binding mitochondrial carrier protein Aralar2 [IPR029658]", "Caldesmon [IPR006017]", "Caldesmon/lymphocyte specific protein [IPR006018]", "Calpain-1 [IPR029643]", "Calpain-2 [IPR029539]", "Calpastatin [IPR026998]", "Calponin-2 [IPR029974]", "Calponin/LIMCH1 [IPR001997]", "Calreticulin [IPR009169]", "Calreticulin/calnexin [IPR001580]", "Calumenin [IPR027239]", "Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 1 [IPR030376]", "Caprin [IPR028816]", "Carbamoyl-phosphate synthase, large subunit [IPR006275]", "Carbamoyl-phosphate synthase, small subunit [IPR006274]", "Cartilage-associated protein [IPR033212]", "Casein Kinase 2, subunit alpha [IPR045216]", "Casein kinase II, regulatory subunit [IPR000704]", "Cat eye syndrome critical region protein 5 [IPR029621]", "Catechol O-methyltransferase, eukaryotic [IPR017128]", "Catenin delta-1 [IPR028439]", "Cation efflux protein [IPR002524]", "Cation-dependent mannose-6-phosphate receptor [IPR000296]", "Cation/H+ exchanger, CPA1 family [IPR018422]", "Cationic amino acid transport permease [IPR004755]", "Cdc37 [IPR004918]", "Cdc42 [IPR037874]", "Cdc73/Parafibromin [IPR007852]", "Cell cycle and apoptosis regulator protein 2 [IPR028811]", "Cell cycle and apoptosis regulator protein [IPR025224]", "Cell cycle checkpoint, Hus1 [IPR016580]", "Cell cycle regulator Mat89Bb [IPR019355]", "Cell division cycle protein 123 [IPR009772]", "Cell division cycle-associated protein 2 [IPR033064]", "Cell growth-regulating nucleolar protein [IPR039999]", "Cell-cycle alteration and expression-elevated protein in tumour [IPR032337]", "Centromere protein Cenp-F [IPR043513]", "Centromere protein I [IPR012485]", "Centrosomal protein of 170kDa [IPR026644]", "Centrosomal protein of 44kDa [IPR033603]", "Centrosomal protein of 55kDa [IPR038926]", "Ceroid-lipofuscinosis neuronal protein 5 [IPR026138]", "Cgr1-like [IPR005579]", "Chaperone DnaJ [IPR012724]", "Chaperone DnaK [IPR012725]", "Chaperone tailless complex polypeptide 1 (TCP-1) [IPR017998]", "Chaperonin Cpn60/GroEL [IPR001844]", "Chaperonin Cpn60/GroEL/TCP-1 family [IPR002423]", "Checkpoint protein Hus1/Mec3 [IPR007150]", "Chitobiosyldiphosphodolichol beta-mannosyltransferase ALG1-like [IPR026051]", "Chloride channel ClC-3 [IPR002245]", "Chloride channel, voltage gated [IPR001807]", "Chloride intracellular channel protein 1 [IPR030259]", "Chloride intracellular channel protein 4/6 [IPR030257]", "Choline/ethanolamine phosphotransferase [IPR014472]", "Chromatid cohesion factor MAU2 [IPR019440]", "Chromatin assembly factor 1 subunit A [IPR022043]", "Chromatin assembly factor 1 subunit Cac2/CHAF1B/FAS2 [IPR045145]", "Chromatin-remodeling complex component Sfh1/SNF5 [IPR017393]", "Chromobox protein homologue 3 [IPR038033]", "Chromodomain-helicase-DNA-binding protein 1-like [IPR031053]", "Chromosome alignment-maintaining phosphoprotein 1 [IPR039330]", "Cilia- and flagella-associated protein 20/CFAP20DC [IPR040441]", "Citrate synthase [IPR002020]", "Citrate synthase, eukaryotic-type [IPR010109]", "Class I-like SAM-dependent O-methyltransferase [IPR002935]", "Clathrin adaptor, mu subunit [IPR001392]", "Clathrin coat assembly protein AP180-like [IPR045192]", "Clathrin interactor 1 [IPR030544]", "Clathrin light chain [IPR000996]", "Clathrin, heavy chain [IPR016341]", "Cleavage and polyadenylation specificity factor subunit 2 [IPR027075]", "Cleavage and polyadenylation specificity factor subunit 7 [IPR034770]", "Cleavage stimulation factor subunit 1-like [IPR044633]", "Cleavage/polyadenylation specificity factor subunit 5 [IPR016706]", "Cleft lip and palate transmembrane 1 [IPR008429]", "Cleft lip and palate transmembrane protein 1-like protein [IPR030434]", "Clp protease proteolytic subunit /Translocation-enhancing protein TepA [IPR023562]", "Clp protease, ATP-binding subunit ClpX [IPR004487]", "ClpA/B family [IPR001270]", "Co-chaperone protein p23-like [IPR045250]", "Coactosin-like protein [IPR030502]", "Coatomer alpha subunit [IPR016391]", "Coatomer beta subunit (COPB1) [IPR016460]", "Coatomer beta' subunit (COPB2) [IPR016453]", "Coatomer delta subunit [IPR027059]", "Coatomer gamma subunit [IPR017106]", "Coatomer subunit zeta [IPR039652]", "Cobalamin-dependent methionine synthase [IPR011822]", "Coenzyme A transferase family I [IPR004165]", "Cofactor of BRCA1 [IPR010405]", "Cofilin 1 [IPR027234]", "Cohesin subunit Scc3/SA [IPR039662]", "Coiled-coil domain-containing protein 124/Oxs1 [IPR010422]", "Coiled-coil domain-containing protein 134 [IPR026321]", "Coiled-coil domain-containing protein 137 [IPR026680]", "Coiled-coil domain-containing protein 22 [IPR008530]", "Coiled-coil domain-containing protein 43 [IPR037666]", "Coiled-coil domain-containing protein 86 [IPR026570]", "Coiled-coil domain-containing protein 93 [IPR039116]", "Coilin [IPR024822]", "Complex I intermediate-associated protein 30, mitochondrial [IPR039131]", "Condensin complex subunit 2/barren [IPR022816]", "Condensin complex subunit 3 [IPR027165]", "Condensin subunit 1 [IPR007673]", "Condensin subunit 1/Condensin-2 complex subunit D3 [IPR026971]", "Condensin-2 complex subunit D3 [IPR012371]", "Conserved oligomeric Golgi complex subunit 7 [IPR019335]", "Constitutive coactivator of PPAR-gamma [IPR026784]", "Copine [IPR045052]", "Copper chaperone SCO1/SenC [IPR003782]", "Coproporphyrinogen III oxidase, aerobic [IPR001260]", "Core histone macro-H2A [IPR021171]", "Core-binding factor, beta subunit [IPR003417]", "Coronin 1C [IPR027333]", "Coronin [IPR015505]", "Cortactin [IPR015503]", "Csn12 family [IPR045114]", "Cullin [IPR045093]", "Cullin-4B [IPR033044]", "Cullin-associated NEDD8-dissociated protein 1/2 [IPR039852]", "Cwf19-like protein [IPR040194]", "Cyclic nucleotide phosphodiesterase [IPR008431]", "Cyclin [IPR039361]", "Cyclophilin-RNA interacting protein [IPR035542]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase [IPR024936]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like [IPR044666]", "Cysteine-tRNA ligase [IPR015803]", "Cysteinyl-tRNA synthetase/mycothiol ligase [IPR024909]", "Cystinyl aminopeptidase [IPR034017]", "Cytochrome B561-related [IPR019176]", "Cytochrome P450 [IPR001128]", "Cytochrome P450, E-class, group IV [IPR002403]", "Cytochrome b-c1 complex subunit 7 [IPR003197]", "Cytochrome b-c1 complex subunit 8 [IPR004205]", "Cytochrome b-c1 complex subunit 9 [IPR008027]", "Cytochrome c oxidase assembly factor 3, mitochondrial [IPR041752]", "Cytochrome c oxidase subunit 6C [IPR004204]", "Cytochrome c oxidase subunit IV [IPR013288]", "Cytochrome c oxidase subunit IV family [IPR004203]", "Cytochrome c oxidase subunit VII [IPR039297]", "Cytochrome c oxidase subunit VIIa, metazoa [IPR003177]", "Cytochrome c oxidase subunit VIIc [IPR004202]", "Cytochrome c oxidase, subunit Va/VI [IPR003204]", "Cytochrome c oxidase, subunit Vb [IPR002124]", "Cytochrome c/quinol oxidase subunit II [IPR045187]", "Cytochrome c1 [IPR002326]", "Cytoplasmic FMR1-interacting [IPR008081]", "Cytoskeleton-associated protein 2 family [IPR026165]", "Cytoskeleton-associated protein 4 [IPR028428]", "Cytosolic acyl coenzyme A thioester hydrolase [IPR040170]", "Cytosolic nonspecific dipeptidase/DUG1 [IPR017153]", "Cytospin-A [IPR040166]", "D-3-phosphoglycerate dehydrogenase [IPR006236]", "DAD/Ost2 [IPR003038]", "DDRGK domain containing protein [IPR019153]", "DDX54/DBP10 family [IPR033517]", "DENR family, eukaryotes [IPR005873]", "DET1- and DDB1-associated protein 1 [IPR033575]", "DNA (cytosine-5)-methyltransferase 1-like [IPR017198]", "DNA damage-binding protein 1 [IPR031297]", "DNA double-strand break repair protein Mre11 [IPR003701]", "DNA fragmentation factor 45 [IPR017299]", "DNA helicase, ATP-dependent, RecQ type [IPR004589]", "DNA ligase, ATP-dependent [IPR000977]", "DNA mismatch repair Msh2-type [IPR011184]", "DNA mismatch repair MutS family [IPR045076]", "DNA mismatch repair protein Msh2 [IPR032642]", "DNA mismatch repair protein MutS/MSH [IPR017261]", "DNA polymerase V/Myb-binding protein 1A [IPR007015]", "DNA polymerase delta/II small subunit family [IPR024826]", "DNA polymerase epsilon catalytic subunit [IPR029703]", "DNA primase large subunit, eukaryotic/archaeal [IPR007238]", "DNA primase, large subunit, eukaryotic [IPR016558]", "DNA primase, small subunit [IPR002755]", "DNA primase, small subunit, eukaryotic/archaeal [IPR014052]", "DNA repair protein Rad50, eukaryotes [IPR004584]", "DNA repair protein XPF [IPR006167]", "DNA repair/transcription protein MET18/MMS19 [IPR039920]", "DNA replication complex GINS protein Psf2 [IPR007257]", "DNA replication licensing factor Mcm2 [IPR008045]", "DNA replication licensing factor Mcm3 [IPR008046]", "DNA replication licensing factor Mcm5 [IPR008048]", "DNA replication licensing factor Mcm6 [IPR008049]", "DNA replication licensing factor Mcm7 [IPR008050]", "DNA topoisomerase I [IPR001631]", "DNA topoisomerase II, eukaryotic-type [IPR001154]", "DNA topoisomerase II-beta [IPR028467]", "DNA topoisomerase, type IIA [IPR001241]", "DNA-directed DNA polymerase, family B [IPR006172]", "DNA-directed RNA pol I, largest subunit [IPR015699]", "DNA-directed RNA polymerase II subunit Rpb4-like [IPR045222]", "DNA-directed RNA polymerase III subunit RPC3 [IPR039748]", "DNA-directed RNA polymerase subunit Rpo5/Rpb5 [IPR014381]", "DNA-directed RNA polymerase, phage-type [IPR002092]", "DNA-directed RNA polymerase, subunit 2 [IPR015712]", "DNA-directed RNA polymerase, subunit beta-prime [IPR045867]", "DNA-directed RNA polymerases I and III subunit AC40 [IPR033901]", "DNA2/NAM7-like helicase [IPR045055]", "DPM1-like [IPR039528]", "Death-inducer obliterator 1 [IPR033082]", "Dedicator of cytokinesis [IPR026791]", "Defective-in-cullin neddylation protein [IPR014764]", "Delta l-pyrroline-5-carboxylate synthetase [IPR005766]", "Delta(24)-sterol reductase [IPR040165]", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase Ech1-like [IPR045002]", "Delta-1-pyrroline-5-carboxylate dehydrogenase [IPR005931]", "Deoxyhypusine hydroxylase [IPR027517]", "Deoxyuridine triphosphate nucleotidohydrolase [IPR008181]", "Dephospho-CoA kinase [IPR001977]", "Derlin [IPR007599]", "Dermcidin [IPR028130]", "Dermcidin/Lacritin [IPR043557]", "Desmoglein [IPR009123]", "Desmoplakin [IPR028462]", "Desmosomal cadherin [IPR009122]", "Destrin [IPR029924]", "Deubiquitinating enzyme MINDY-3/4 [IPR039785]", "Developmentally regulated GTP-binding protein [IPR045001]", "Dihydrofolate reductase [IPR012259]", "Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component [IPR045257]", "Dihydrolipoamide dehydrogenase [IPR006258]", "Dihydrolipoamide succinyltransferase [IPR006255]", "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex [IPR006257]", "Dihydropyrimidinase-related protein 2 [IPR030615]", "Dihydroxyacetone phosphate acyltransferase [IPR028353]", "Dim1 family [IPR004123]", "Dimethylarginine dimethylaminohydrolase [IPR033199]", "Dipeptidyl-peptidase 3 [IPR005317]", "Diphthine synthase [IPR004551]", "Divalent ion tolerance protein, CutA [IPR004323]", "DnaJ homolog subfamily A member 1/2-like [IPR044713]", "DnaJ homolog subfamily C member 8 [IPR042858]", "DnaJ homologue subfamily C member 10 [IPR021170]", "DnaJ homologue subfamily C, GRV2/DNAJC13 [IPR044978]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48kDa subunit [IPR005013]", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1 [IPR008814]", "Drebrin [IPR028438]", "Drebrin-like protein [IPR029923]", "Dynactin subunit 3 [IPR009991]", "Dynactin subunit 4 [IPR008603]", "Dynamin [IPR022812]", "Dynamin-1-like protein [IPR030556]", "Dynamin-2 [IPR027188]", "Dynamin-like 120kDa protein, mitochondrial [IPR033047]", "Dynamitin [IPR028133]", "Dynein 1 light intermediate chain [IPR008467]", "Dynein family light intermediate chain [IPR022780]", "Dynein light chain Tctex-1 like [IPR005334]", "Dynein light chain, type 1/2 [IPR001372]", "Dynein regulator LIS1 [IPR017252]", "Dyslexia-associated protein KIAA0319-like [IPR029865]", "Dystrophin/utrophin [IPR035436]", "E3 SUMO-protein ligase Nse2 (Mms21) [IPR026846]", "E3 UFM1-protein ligase 1 [IPR018611]", "E3 ubiquitin ligase Bre1 [IPR013956]", "E3 ubiquitin ligase RBR family [IPR031127]", "E3 ubiquitin ligase UBR4-like [IPR045189]", "E3 ubiquitin-protein ligase ARIH2 [IPR031126]", "E3 ubiquitin-protein ligase CHIP/LubX [IPR045200]", "E3 ubiquitin-protein ligase HECTD1/TRIP12-like [IPR045322]", "E3 ubiquitin-protein ligase RBBP6 family [IPR033489]", "E3 ubiquitin-protein ligase RING1/RING2 [IPR043540]", "E3 ubiquitin-protein ligase RING2 [IPR037937]", "E3 ubiquitin-protein ligase RNF14 [IPR031128]", "E3 ubiquitin-protein ligase UBR1-like [IPR039164]", "E3 ubiquitin-protein ligase, SMURF1 type [IPR024928]", "EB1, Metazoa [IPR027739]", "EB2, vertebrate [IPR027735]", "EH domain-containing protein 1/3 [IPR029951]", "EH domain-containing protein 4 [IPR029952]", "ELMO domain-containing protein 2 [IPR030724]", "ELP3/YhcC [IPR039661]", "ER membrane protein complex subunit 1 [IPR026895]", "ER membrane protein complex subunit 2-like [IPR039856]", "ER membrane protein complex subunit 7 [IPR039163]", "ERAP2 aminopeptidase [IPR033528]", "ERG2/sigma1 receptor-like [IPR006716]", "ERp19 [IPR037462]", "ESCRT-II complex, Vps25 subunit [IPR008570]", "Electron transfer flavoprotein alpha subunit/FixB [IPR001308]", "Electron transfer flavoprotein, beta subunit [IPR012255]", "Electron transfer flavoprotein-ubiquinone oxidoreductase [IPR040156]", "Elongation factor G1-like [IPR045044]", "Elongator complex protein 1 [IPR006849]", "Elongator complex protein 2 [IPR037289]", "Elongator complex protein 3-like [IPR034687]", "Elongator complex protein 4 [IPR008728]", "Elongin B [IPR039049]", "Elongin-C [IPR039948]", "Emerin [IPR035004]", "Endonuclease domain-containing 1 protein [IPR039015]", "Endophilin-A [IPR028501]", "Endophilin-B1 [IPR028503]", "Endoplasmic reticulum aninopeptidase 1 [IPR033520]", "Endoplasmic reticulum oxidoreductin 1 [IPR007266]", "Endoplasmic reticulum protein SC65 [IPR033213]", "Endoplasmic reticulum resident protein 29 [IPR016855]", "Endoplasmic reticulum vesicle transporter [IPR045888]", "Endosulphine [IPR006760]", "Endothelin-converting enzyme 1 [IPR029734]", "Enhancer of mRNA-decapping protein 4-like [IPR045152]", "Enhancer of rudimentary [IPR000781]", "Enolase [IPR000941]", "Enoyl-CoA hydratase/isomerase [IPR001753]", "Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type [IPR032259]", "Epimerase family protein SDR39U1 [IPR010099]", "Epoxide hydrolase [IPR016292]", "Epoxide hydrolase-like [IPR000639]", "Erg28 [IPR005352]", "Ergosterol biosynthesis ERG4/ERG24 [IPR001171]", "Erlin1/2 [IPR033294]", "Esterase-like [IPR000801]", "Etoposide-induced 2.4 [IPR009890]", "Eukaryotic porin/Tom40 [IPR027246]", "Eukaryotic rRNA processing [IPR008610]", "Eukaryotic translation elongation factor 1 epsilon-1 [IPR042450]", "Eukaryotic translation initiation factor 3 subunit A [IPR027512]", "Eukaryotic translation initiation factor 3 subunit B [IPR011400]", "Eukaryotic translation initiation factor 3 subunit D [IPR007783]", "Eukaryotic translation initiation factor 3 subunit E [IPR016650]", "Eukaryotic translation initiation factor 3 subunit F [IPR027531]", "Eukaryotic translation initiation factor 3 subunit G [IPR017334]", "Eukaryotic translation initiation factor 3 subunit H [IPR027524]", "Eukaryotic translation initiation factor 3 subunit I [IPR027525]", "Eukaryotic translation initiation factor 3 subunit J [IPR013906]", "Eukaryotic translation initiation factor 3 subunit K [IPR009374]", "Eukaryotic translation initiation factor 3 subunit M [IPR027528]", "Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7 [IPR045237]", "Eukaryotic translation initiation factor 4 gamma 1 [IPR037584]", "Eukaryotic translation initiation factor 4 gamma 3 [IPR037585]", "Eukaryotic translation initiation factor 4B [IPR033107]", "Exocyst complex component EXOC5/Sec10 [IPR033960]", "Exocyst complex component EXOC6/Sec15 [IPR007225]", "Exocyst complex component Exo70 [IPR004140]", "Exocyst complex component Sec10-like [IPR009976]", "Exonuclease 1 [IPR032641]", "Exosome complex RNA-binding protein 1/RRP40/RRP4 [IPR026699]", "Exosome complex component Csl4 [IPR039771]", "Exosome complex component RRP45 [IPR033100]", "Exosome complex component Rrp43 [IPR033196]", "Exosome complex exonuclease Rrp6-like [IPR045092]", "Exportin 4/7-like [IPR044189]", "Exportin-1/5 [IPR045065]", "Exportin-5 [IPR040018]", "Exportin-7 [IPR040021]", "Exportin-T [IPR040017]", "Ezrin/radixin/moesin [IPR011174]", "Ezrin/radixin/moesin-like [IPR000798]", "F-actin-capping protein subunit alpha [IPR002189]", "F-actin-capping protein subunit beta [IPR001698]", "FACT complex subunit Spt16 [IPR040258]", "FAD synthetase with the MoaB/Mog domain [IPR012183]", "FAD-dependent glycerol-3-phosphate dehydrogenase [IPR000447]", "FAD-dependent oxidoreductase SdhA/FrdA/AprA [IPR030664]", "FAM175 family [IPR023238]", "FAM175 family, BRISC complex, Abro1 subunit [IPR023240]", "FAM177 family [IPR028260]", "FAM98 [IPR018797]", "FMP27 [IPR045167]", "Fanconi anaemia protein FANCD2 [IPR029448]", "Fanconi anemia group I protein [IPR026171]", "Fascin [IPR010431]", "Fascin, metazoans [IPR024703]", "Fascin-1 [IPR030146]", "Fatty acid oxidation complex, alpha subunit, mitochondrial [IPR012803]", "Fatty acid transport protein 4 [IPR030304]", "Fatty acyl-CoA reductase [IPR026055]", "Fcf2/DNTTIP2 [IPR039883]", "Ferredoxin-NADP+ reductase, adrenodoxin-type [IPR021163]", "Ferrochelatase [IPR001015]", "Fibrillarin [IPR000692]", "Filamin family [IPR044801]", "Filamin-B [IPR029874]", "Fimbrin/Plastin [IPR039959]", "Flap endonuclease 1 [IPR023426]", "Flotillin family [IPR027705]", "Formate-tetrahydrofolate ligase, FTHFS [IPR000559]", "Formin, protein diaphanous homologue 1 [IPR027653]", "Formin, protein diaphanous homologue 3 [IPR027654]", "Fragile X mental retardation syndrome-related protein [IPR040148]", "Fructosamine/Ketosamine-3-kinase [IPR016477]", "Fructose-bisphosphate aldolase, class-I [IPR000741]", "Fumarate hydratase, class II [IPR005677]", "Fumarate lyase family [IPR000362]", "Fumarylacetoacetase [IPR005959]", "G-protein alpha subunit, group 12/13 [IPR000469]", "G-protein alpha subunit, group I [IPR001408]", "G-protein, gamma subunit [IPR001770]", "G-rich sequence factor 1 [IPR033106]", "G10 protein [IPR001748]", "GDP dissociation inhibitor [IPR018203]", "GDP-L-fucose synthase/GDP-L-colitose synthase [IPR028614]", "GDP-mannose 4,6-dehydratase [IPR006368]", "GH3 family [IPR004993]", "GINS complex subunit Sld5 [IPR008591]", "GINS complex, subunit Psf3 [IPR010492]", "GOLM1/CASC4 family [IPR026139]", "GPI transamidase component Gaa1 [IPR007246]", "GPI transamidase component PIG-T [IPR007245]", "GPI-anchor transamidase [IPR028361]", "GRASP55/65 [IPR007583]", "GRIM-19 [IPR009346]", "GTP-binding protein 1 [IPR039263]", "GTP-binding protein Era [IPR005662]", "GTP-binding protein Obg/CgtA [IPR014100]", "Galactokinase [IPR000705]", "Galectin-3 [IPR015534]", "Galectin-like [IPR044156]", "Gamma-adducin [IPR027772]", "Gamma-glutamylcyclotransferase [IPR017939]", "Gamma-tubulin complex component protein [IPR007259]", "Ganglioside GM2 activator [IPR028996]", "Ganglioside-induced differentiation-associated protein 1 [IPR034336]", "Gasdermin-E [IPR042377]", "Gem-associated protein 4 [IPR033265]", "General transcription factor 3C polypeptide 4 [IPR044230]", "Geranylgeranyl transferase type-2 subunit alpha [IPR032955]", "Glia maturation factor [IPR011171]", "Glomulin/ALF4 [IPR019516]", "Glucosamine-6-phosphate isomerase [IPR004547]", "Glucosamine-fructose-6-phosphate aminotransferase, isomerising [IPR005855]", "Glucose transporter GLUT [IPR045263]", "Glucose transporter, type 1 (GLUT1) [IPR002439]", "Glucose-6-phosphate dehydrogenase [IPR001282]", "Glucosidase II beta subunit-like [IPR039794]", "Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase [IPR005715]", "Glutamate carboxypeptidase 2-like [IPR039373]", "Glutamate--cysteine ligase regulatory subunit [IPR032963]", "Glutamate-tRNA ligase, bacterial/mitochondrial [IPR004527]", "Glutamate/acetylglutamate kinase [IPR001057]", "Glutamate/phenylalanine/leucine/valine dehydrogenase [IPR006095]", "Glutaminase [IPR015868]", "Glutamine-tRNA synthetase [IPR004514]", "Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic [IPR004526]", "Glutamyl/glutaminyl-tRNA synthetase [IPR000924]", "Glutathione S-transferase Omega/Tau-like [IPR045073]", "Glutathione S-transferase kappa [IPR044088]", "Glutathione S-transferase, Mu class [IPR003081]", "Glutathione S-transferase, omega-class [IPR005442]", "Glutathione Transferase family [IPR040079]", "Glutathione peroxidase Gpx7, putative [IPR013376]", "Glutathione peroxidase [IPR000889]", "Glutathione reductase, eukaryote/bacterial [IPR006322]", "Glutathione synthase [IPR005615]", "Glyceraldehyde-3-phosphate dehydrogenase, type I [IPR006424]", "Glyceraldehyde/Erythrose phosphate dehydrogenase family [IPR020831]", "Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase [IPR022284]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent [IPR006168]", "Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic [IPR017751]", "Glycine cleavage system P protein [IPR020581]", "Glycine dehydrogenase (decarboxylating) [IPR003437]", "Glycogen debranching enzyme [IPR010401]", "Glycogen debranching enzyme, metazoa [IPR006421]", "Glycogen synthase [IPR008631]", "Glycogen/starch/alpha-glucan phosphorylase [IPR011833]", "Glycoside hydrolase family 30 [IPR001139]", "Glycoside hydrolase family 31 [IPR000322]", "Glycoside hydrolase family 63 [IPR004888]", "Glycoside hydrolase, family 2 [IPR006101]", "Glycoside hydrolase, family 27 [IPR002241]", "Glycoside hydrolase, family 29 [IPR000933]", "Glycoside hydrolase, family 35 [IPR001944]", "Glycosyl transferase, family 13 [IPR004139]", "Glycosyl transferase, family 25 [IPR002654]", "Glycosyl transferase, family 31 [IPR002659]", "Glycosyl transferase, family 35 [IPR000811]", "Glycosyl transferase, family 8 [IPR002495]", "Glycyl-tRNA synthetase [IPR002315]", "Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2 [IPR027031]", "Glyoxalase I [IPR004361]", "Glyoxalase domain-containing protein 4 [IPR043193]", "Golgi apparatus protein 1 [IPR039728]", "Golgi integral membrane protein 4 [IPR042336]", "Golgi membrane protein 1 [IPR026143]", "Golgi to ER traffic protein 4 [IPR007317]", "Golgin subfamily B member 1 [IPR026202]", "Graves disease carrier protein [IPR002167]", "GroES chaperonin family [IPR020818]", "Growth arrest/ DNA-damage-inducible protein-interacting protein 1 [IPR018472]", "GrpE nucleotide exchange factor [IPR000740]", "Guanidinoacetate N-methyltransferase [IPR016550]", "Guanine nucleotide binding protein (G-protein), alpha subunit [IPR001019]", "Guanine nucleotide exchange factor, Ric8 [IPR019318]", "Guanine nucleotide-exchange factor Sec12-like [IPR045260]", "H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 [IPR007504]", "H/ACA ribonucleoprotein complex, subunit Nhp2, eukaryote [IPR002415]", "HAD hydrolase, LHPP/HDHD2 [IPR006355]", "HAD hydrolase, subfamily IA [IPR006439]", "HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase [IPR008380]", "HAD-superfamily hydrolase, subfamily IIA [IPR006357]", "HAD-superfamily hydrolase, subfamily IIA, CECR5 [IPR006353]", "HAUS augmin-like complex subunit 5 [IPR029131]", "HAUS complex subunit 5, metazoa [IPR026215]", "HCCA isomerase/glutathione S-transferase kappa [IPR014440]", "HEXIM [IPR024872]", "HIRA-interacting protein 3 [IPR037647]", "Haem oxygenase [IPR002051]", "Haem oxygenase-like [IPR016053]", "Haloacid dehalogenase-like hydrolase [IPR041492]", "Ham1-like protein [IPR002637]", "Heat shock 70kDa protein 12A [IPR026685]", "Heat shock 70kDa protein 13 [IPR042048]", "Heat shock protein 70 family [IPR013126]", "Heat shock protein Hsp90 family [IPR001404]", "Heat shock protein Sti1-like [IPR045248]", "Helicase MOV-10 [IPR026122]", "Helicase XPB/Ssl2 [IPR001161]", "Helicase superfamily 1/2, DinG/Rad3-like [IPR045028]", "Heme A synthase, type 2 [IPR023754]", "Heparan sulphate 2-O-sulfotransferase [IPR007734]", "Heterochromatin protein 1-binding protein 3 [IPR033061]", "Heterogeneous nuclear ribonucleoprotein C [IPR017347]", "Heterogeneous nuclear ribonucleoprotein K [IPR033090]", "Heterogeneous nuclear ribonucleoprotein M [IPR024667]", "Heterogeneous nuclear ribonucleoprotein U [IPR026745]", "Heterogeneous nuclear ribonucleoprotein U-like protein 1 [IPR027025]", "Hexokinase [IPR001312]", "High mobility group protein HMG-I/HMG-Y, chordates [IPR031079]", "High mobility group protein HMGA [IPR000116]", "High mobility group protein HMGB1 [IPR031076]", "High mobility group protein HMGB3 [IPR031077]", "High mobility group protein HMGN [IPR000079]", "Histidine phosphatase superfamily, clade-1 [IPR013078]", "Histidine phosphatase superfamily, clade-2 [IPR000560]", "Histidine triad (HIT) protein [IPR001310]", "Histone H2A [IPR002119]", "Histone H4 [IPR001951]", "Histone PARylation factor 1 [IPR019361]", "Histone acetyltransferase type B, catalytic subunit [IPR017380]", "Histone deacetylase [IPR003084]", "Histone deacetylase complex, SAP18 subunit [IPR017250]", "Histone deacetylase family [IPR000286]", "Histone demethylase JHDM2-like [IPR045109]", "Histone lysine-specific demethylase [IPR017366]", "Histone-lysine N-methyltransferase 2A [IPR037927]", "Histone-lysine N-methyltransferase EHMT1 [IPR038035]", "Histone-lysine N-methyltransferase EHMT1/EHMT2 [IPR043550]", "Histone-lysine N-methyltransferase SETD2, animal [IPR042294]", "Histone-lysine N-methyltransferase SETDB1 [IPR025796]", "Histone-lysine N-methyltransferase Smyd3 [IPR025805]", "HnRNP R/Q splicing factor [IPR006535]", "HnRNP-L/PTB [IPR006536]", "Host cell factor 1 [IPR037854]", "Host cell factor [IPR043536]", "Huntingtin [IPR000091]", "Huntingtin family [IPR028426]", "Hydantoinase/dihydropyrimidinase [IPR011778]", "Hydroxymethylglutaryl-CoA reductase, class I/II [IPR002202]", "Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type [IPR004554]", "Hydroxymethylglutaryl-CoA reductase, metazoan [IPR004816]", "Hydroxymethylglutaryl-CoA synthase, eukaryotic [IPR010122]", "Hypoxanthine phosphoribosyl transferase [IPR005904]", "I-BAR domain containing protein IRSp53 [IPR030128]", "I-BAR domain containing protein IRSp53/IRTKS/Pinkbar [IPR027681]", "ICln [IPR003521]", "IQ motif and SEC7 domain-containing protein 1 [IPR030737]", "Importin beta family [IPR040122]", "Importin subunit alpha [IPR024931]", "Inhibitor of nuclear factor kappa-B kinase-interacting protein [IPR024152]", "Initiation factor 2B-related [IPR000649]", "Initiation factor 4G [IPR045208]", "Inner centromere protein [IPR039130]", "Inner nuclear membrane protein Man1 [IPR034997]", "Inorganic pyrophosphatase [IPR008162]", "Inosine triphosphate pyrophosphatase [IPR027502]", "Inosine-5'-monophosphate dehydrogenase [IPR005990]", "Inositol monophosphatase-like [IPR000760]", "Inositol-tetrakisphosphate 1-kinase [IPR008656]", "Insulin receptor substrate [IPR039011]", "Insulin-like growth factor 2 mRNA-binding protein 2 [IPR028743]", "Integral membrane protein 2 [IPR040145]", "Integral membrane protein EMC3/TMCO1-like [IPR002809]", "Integrator complex subunit 1 [IPR038902]", "Integrator complex subunit 14 [IPR039841]", "Integrator complex subunit 3 [IPR045334]", "Integrin beta subunit [IPR015812]", "Integrin beta-1 subunit [IPR027071]", "Interferon gamma receptor alpha subunit [IPR008355]", "Interferon-induced protein with tetratricopeptide repeat 5 [IPR024125]", "Interleukin enhancer-binding factor 3 [IPR033099]", "Intermembrane space protein MIX23 [IPR019171]", "Intracellular chloride channel [IPR002946]", "Intraflagellar transport protein 25 [IPR033558]", "Intraflagellar transport protein 27 homologue, eukaryotes [IPR034112]", "Intron Large complex component GCFC2-like [IPR012890]", "Iron regulatory protein 1 [IPR029784]", "Isocitrate dehydrogenase NAD-dependent [IPR004434]", "Isocitrate dehydrogenase NADP-dependent [IPR004790]", "Isoleucine-tRNA ligase [IPR002301]", "Isoleucine-tRNA ligase, type 1 [IPR023585]", "Isoleucine-tRNA ligase, type 2 [IPR023586]", "Isopentenyl-diphosphate delta-isomerase, type 1 [IPR011876]", "Isoprenylcysteine carboxyl methyltransferase [IPR007269]", "Isovaleryl-CoA dehydrogenase [IPR034183]", "J-protein Zuotin/DnaJC2 [IPR044634]", "JNK-interacting protein 3/4 [IPR039911]", "Junction plakoglobin [IPR030461]", "Junctional adhesion molecule A [IPR042456]", "KH domain-containing BBP-like [IPR045071]", "KIF-1 binding protein [IPR022083]", "KIN17-like protein [IPR037321]", "KRR1 interacting protein 1 [IPR018034]", "Kae1/TsaD family [IPR017861]", "Keratin, type I [IPR002957]", "Kindlin/fermitin [IPR037843]", "Kinectin [IPR024854]", "Kinesin light chain [IPR002151]", "Kinesin-like protein KIF20A [IPR027326]", "Kinesin-like protein KIF22 (Kid) [IPR026986]", "Kinesin-like protein [IPR027640]", "Kinetochore protein Spc25 [IPR045143]", "Kinetochore-Ndc80 subunit Spc24 [IPR013252]", "Ku70 [IPR006165]", "Ku80 [IPR024193]", "Kynurenine--oxoglutarate transaminase 3 [IPR034612]", "L-lactate dehydrogenase [IPR011304]", "L-lactate/malate dehydrogenase [IPR001557]", "L-type amino acid transporter [IPR004760]", "LAMTOR1/MEH1 [IPR028209]", "LEM domain-containing protein 2 [IPR034994]", "LETM1/MDM38-like [IPR044202]", "LIM domain and actin-binding protein 1 [IPR028740]", "LIM domain and actin-binding protein LIMA-like [IPR045268]", "La domain containing protein [IPR045180]", "LanC-like protein, eukaryotic [IPR020464]", "Lanthionine synthetase C-like [IPR007822]", "Las1 [IPR007174]", "Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase [IPR003386]", "Lethal(2) giant larvae protein [IPR000664]", "Leucine zipper transcription factor-like protein 1 [IPR026157]", "Leucine-rich PPR motif-containing protein [IPR033490]", "Leucine-rich repeat-containing 41 [IPR026137]", "Leucine-tRNA ligase [IPR002302]", "Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic [IPR004493]", "Leukocyte surface antigen CD47 [IPR006704]", "Leukotriene A4 hydrolase/leucine aminopeptidase [IPR012777]", "Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase [IPR014190]", "Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3 [IPR027141]", "Linker histone H1/H5 [IPR005819]", "Lon protease [IPR027065]", "Lon protease homologue, chloroplastic/mitochondrial [IPR027503]", "Lon protease, bacterial/eukaryotic-type [IPR004815]", "Long-chain fatty acid CoA synthetase, eukaryotic [IPR045311]", "Low temperature viability protein Ltv1 [IPR007307]", "Luc7-related [IPR004882]", "Lupus La protein [IPR002344]", "Lysine-tRNA ligase, class II [IPR002313]", "Lysophosphatidylserine lipase ABHD12 [IPR026605]", "Lysosomal thioesterase PPT2 [IPR030295]", "Lysosome membrane protein II [IPR005429]", "Lysosome-associated membrane glycoprotein [IPR002000]", "MDN2-binding protein [IPR039061]", "METTL16/RlmF family [IPR010286]", "MICOS complex subunit MIC19/MIC25 [IPR007964]", "MICOS complex subunit MIC26/MIC27 [IPR019166]", "MICOS complex subunit MIC26/MIC27, animal [IPR033182]", "MICOS complex subunit Mic13 [IPR026769]", "MKRN-like [IPR045072]", "MOB kinase activator family [IPR005301]", "MRG [IPR008676]", "MRPS27/PTCD2 [IPR034913]", "Macrophage migration inhibitory factor [IPR001398]", "Mad2-like [IPR045091]", "Magnesium transporter protein 1 [IPR006844]", "Major facilitator superfamily [IPR011701]", "Major facilitator, sugar transporter-like [IPR005828]", "Mak16 protein [IPR006958]", "Malate dehydrogenase, NAD-dependent, cytosolic [IPR011274]", "Malate dehydrogenase, type 1 [IPR010097]", "Malate dehydrogenase, type 2 [IPR010945]", "Malectin [IPR039155]", "Malic oxidoreductase [IPR001891]", "Manganese/iron superoxide dismutase [IPR001189]", "Mannose-6-phosphate isomerase [IPR016305]", "Mannose-6-phosphate isomerase, type I [IPR001250]", "Mannose-6-phosphate receptor [IPR028927]", "Mannose-P-dolichol utilization defect 1 protein [IPR016817]", "Matrix-remodeling-associated protein 7 [IPR026622]", "Mediator complex, subunit Med24, [IPR021429]", "Mediator complex, subunit Med4 [IPR019258]", "Medium-chain dehydrogenase/reductase [IPR045010]", "Medium-chain specific acyl-CoA dehydrogenase [IPR034180]", "Melanoma-associated antigen D2 [IPR028810]", "Melanoma-associated antigen [IPR037445]", "Membralin [IPR019144]", "Membrane insertase YidC/ALB3/OXA1/COX18 [IPR001708]", "Membrane bound O-acyl transferase, MBOAT [IPR004299]", "Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein [IPR001129]", "Mesoderm induction early response protein/metastasis-associated protein [IPR040138]", "Metal-dependent protein hydrolase [IPR003226]", "Metastasis-associated protein MTA2 [IPR037964]", "Methionine-tRNA ligase, type 1 [IPR023458]", "Methionyl-tRNA synthetase [IPR014758]", "Methyl-CpG binding protein MeCP2 [IPR017353]", "Methyl-CpG binding protein MeCP2/MBD4 [IPR045138]", "Methyl-CpG-binding domain protein 3 [IPR037965]", "Methylcrotonoyl-CoA carboxylase beta chain MCCB/AccD1-like [IPR045190]", "Methylmalonate-semialdehyde dehydrogenase [IPR010061]", "Methylmalonic aciduria and homocystinuria type D protein [IPR019362]", "Methylpurine-DNA glycosylase [IPR003180]", "Methylthioadenosine phosphorylase (MTAP) [IPR010044]", "Methylthiotransferase [IPR005839]", "Methyltransferase METTL16/PsiM [IPR017182]", "Methyltransferase, trithorax [IPR016569]", "Mevalonate/galactokinase [IPR006206]", "Mff/Tango-11 [IPR008518]", "MiaB-like tRNA modifying enzyme, archaeal-type [IPR006466]", "Microfibrillar-associated protein 1 [IPR033194]", "Microtubule associated protein 1 [IPR026074]", "Microtubule-associated protein 1B [IPR027321]", "Microtubule-associated protein 4 [IPR027323]", "Microtubule-associated protein Jupiter [IPR033335]", "Microtubule-associated protein RP/EB [IPR027328]", "Microtubule-associated protein, MAP65/Ase1/PRC1 [IPR007145]", "Midasin [IPR012099]", "Midline-1 [IPR027727]", "Mini-chromosome maintenance complex protein 4 [IPR008047]", "Mini-chromosome maintenance complex-binding protein [IPR019140]", "Mini-chromosome maintenance protein [IPR031327]", "Mitochondrial 28S ribosomal protein S31 [IPR026299]", "Mitochondrial 28S ribosomal protein S34 [IPR032053]", "Mitochondrial ATP synthase subunit g, animal [IPR016702]", "Mitochondrial ATPase inhibitor [IPR007648]", "Mitochondrial F1-F0 ATP synthase subunit F, predicted [IPR019344]", "Mitochondrial Rho GTPase 1 [IPR029506]", "Mitochondrial Rho GTPase [IPR021181]", "Mitochondrial carrier UCP-like [IPR002030]", "Mitochondrial carrier protein [IPR002067]", "Mitochondrial glycoprotein [IPR003428]", "Mitochondrial import inner membrane translocase subunit Tim44 [IPR017303]", "Mitochondrial import inner membrane translocase subunit Tim50 [IPR027111]", "Mitochondrial import receptor subunit TOM5, metazoa [IPR029179]", "Mitochondrial import receptor subunit Tom22 [IPR005683]", "Mitochondrial inner membrane protein Mitofilin [IPR019133]", "Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678]", "Mitochondrial inner membrane translocase complex, subunit Tim23 [IPR005681]", "Mitochondrial outer membrane translocase complex, subunit Tom5 [IPR019603]", "Mitochondrial outer membrane transport complex protein, metaxin [IPR017410]", "Mitochondrial phosphate carrier protein Pic2/Mir1-like [IPR044677]", "Mitochondrial processing peptidase subunit beta [IPR037718]", "Mitochondrial-processing peptidase subunit alpha [IPR037715]", "Mitofusin family [IPR027094]", "Mitofusin-1 [IPR027088]", "Mitofusin-2 [IPR027089]", "Mitogen-activated protein (MAP) kinase p38-like [IPR008352]", "Mitogen-activated protein (MAP) kinase, ERK1/2 [IPR008349]", "Mitogen-activated protein kinase 14 [IPR038784]", "Mitotic spindle checkpoint protein Bub1/Mad3 [IPR015661]", "Mo25-like [IPR013878]", "Molybdate-anion transporter [IPR008509]", "Molybdate-anion transporter, animal type [IPR030163]", "Molybdopterin biosynthesis protein MoeA-like [IPR038987]", "Monocarboxylate transporter 1 [IPR030757]", "Monocarboxylate transporter [IPR004743]", "Monothiol glutaredoxin-related [IPR004480]", "Mortality factor 4-like protein 1 [IPR038011]", "Mortality factor 4-like protein 2 [IPR038012]", "Mpv17/PMP22 [IPR007248]", "Multi drug resistance-associated protein [IPR005292]", "Multidrug resistance protein 1 [IPR030258]", "Multifunctional methyltransferase subunit Trm112 [IPR039127]", "Multiple myeloma tumor-associated protein 2-like [IPR039207]", "Myelin expression factor 2 [IPR034632]", "Myeloid-derived growth factor [IPR018887]", "Myo-inositol-1-phosphate synthase [IPR002587]", "Myotubularin family [IPR030564]", "Myotubularin-related protein 6 [IPR030581]", "Myristoyl-CoA:protein N-myristoyltransferase [IPR000903]", "Myristoylated alanine-rich C-kinase substrate MARCKS [IPR002101]", "N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 [IPR033202]", "N-acetylglucosamine-6-sulfatase [IPR012251]", "N-acetylglucosamine-6-sulfatase, metazoan [IPR015981]", "N-acetyltransferase B complex, non-catalytic subunit [IPR019183]", "N-alpha-acetyltransferase 40 [IPR039949]", "N-cadherin [IPR030051]", "N-terminal acetyltransferase A, auxiliary subunit [IPR021183]", "NAD(P) transhydrogenase, alpha subunit [IPR026255]", "NAD(P)H-quinone oxidoreductase subunit D/H [IPR022885]", "NAD/FAD transporter SLC25A32-like [IPR044712]", "NADH dehydrogenase, subunit C [IPR010218]", "NADH-quinone oxidoreductase subunit E-like [IPR002023]", "NADH-ubiquinone oxidoreductase, 20 Kd subunit [IPR006138]", "NADH-ubiquinone oxidoreductase, subunit 10 [IPR019377]", "NADH-ubiquinone reductase complex 1 MLRQ subunit [IPR010530]", "NADH:cytochrome b5 reductase-like [IPR001834]", "NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit [IPR019173]", "NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H [IPR001694]", "NADH:ubiquinone oxidoreductase, subunit G [IPR010228]", "NADH:ubiquinone oxidoreductase, subunit NDUFB4 [IPR009866]", "NADPH-cytochrome P450 reductase [IPR023208]", "NDRG [IPR004142]", "NEDD8 ultimate buster 1 [IPR039749]", "NEDD8-activating enzyme E1 catalytic subunit [IPR030468]", "NEDD8-activating enzyme E1 regulatory subunit APP-BP1 [IPR030667]", "NOL6/Upt22 [IPR005554]", "NPC1-like [IPR004765]", "NSF attachment protein [IPR000744]", "Na(+)/H(+) exchange regulatory cofactor NHERF-1 [IPR031199]", "Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 [IPR017300]", "Na+/H+ exchanger [IPR004709]", "Na+/H+ exchanger, isoform 6/7/9 [IPR002090]", "Nck-associated protein 1 [IPR019137]", "Negative cofactor 2 complex subunit beta [IPR042225]", "Negative elongation factor E [IPR033102]", "Nesprin-2 [IPR030266]", "Neurochondrin [IPR008709]", "Neurofilament medium polypeptide [IPR027697]", "Nicalin [IPR016574]", "Nicastrin [IPR008710]", "Nicotinamide phosphoribosyl transferase [IPR016471]", "Nicotinate-nucleotide pyrophosphorylase [IPR004393]", "Nicotinate-nucleotide pyrophosphorylase/Putative pyrophosphorylase ModD [IPR027277]", "Nitric oxide synthase-interacting protein [IPR016818]", "Nonaspanin (TM9SF) [IPR004240]", "Nonsense-mediated mRNA decay protein 3 [IPR039722]", "Nonsense-mediated mRNA decay protein Nmd2/UPF2 [IPR039762]", "Nuclear RNA export factor [IPR030217]", "Nuclear cap-binding protein subunit 1 [IPR027159]", "Nuclear cap-binding protein subunit 3 [IPR019416]", "Nuclear factor hnRNPA1 [IPR021662]", "Nuclear fragile X mental retardation-interacting protein 2 [IPR032747]", "Nuclear mitotic apparatus protein 1 [IPR026650]", "Nuclear polyadenylated RNA-binding protein Nab2/ZC3H14 [IPR040366]", "Nuclear pore complex protein NUP98-NUP96 [IPR037637]", "Nuclear pore complex protein Nup133-like [IPR037624]", "Nuclear pore complex protein [IPR026054]", "Nuclear pore glycoprotein p62, metazoa [IPR033072]", "Nuclear pore membrane glycoprotein 210-like [IPR045197]", "Nuclear pore protein 84/107 [IPR007252]", "Nuclear protein DGCR14/ESS-2 [IPR019148]", "Nuclear protein localization protein 4 [IPR016563]", "Nuclear transport factor 2/Mtr2 [IPR045875]", "Nucleobindin [IPR040250]", "Nucleobindin-1 [IPR040253]", "Nucleobindin-2 [IPR028813]", "Nucleolar GTP-binding protein 1 [IPR024926]", "Nucleolar GTP-binding protein 2 [IPR024929]", "Nucleolar complex protein 2 [IPR005343]", "Nucleolar complex protein 4 [IPR027193]", "Nucleolar complex-associated protein 3 [IPR016903]", "Nucleolar pre-ribosomal-associated protein 1 [IPR039844]", "Nucleolar protein 10/Enp2 [IPR040382]", "Nucleolar protein 11 [IPR042859]", "Nucleolar protein 14 [IPR007276]", "Nucleolar protein 7 [IPR039626]", "Nucleolar protein 9 [IPR040000]", "Nucleolar protein Nop56/Nop58 [IPR045056]", "Nucleolar, Nop52 [IPR010301]", "Nucleoplasmin family [IPR004301]", "Nucleoporin NSP1/NUP62 [IPR026010]", "Nucleoporin NUP88/NUP82 [IPR037700]", "Nucleoporin Nup120/160 [IPR021717]", "Nucleoporin Nup186/Nup192/Nup205 [IPR021827]", "Nucleoporin Nup188 [IPR044840]", "Nucleoporin Nup37 [IPR037626]", "Nucleoporin Nup54/Nup57/Nup44 [IPR024864]", "Nucleoporin Nup85-like [IPR011502]", "Nucleoporin Nup88 [IPR019321]", "Nucleoporin Seh1 [IPR037597]", "Nucleoporin interacting component Nup93/Nic96 [IPR007231]", "Nucleoporin p58/p45 [IPR024882]", "Nucleoporin peptidase S59-like [IPR037665]", "Nucleoporin protein Ndc1-Nup [IPR019049]", "Nucleoporin, Nup155-like [IPR004870]", "Nucleoside 2-deoxyribosyltransferase [IPR007710]", "Nucleoside diphosphate kinase [IPR001564]", "Nucleoside-triphosphatase, THEP1 type [IPR004948]", "Nucleosome assembly protein (NAP) [IPR002164]", "Nucleosome-remodeling factor subunit BPTF [IPR038028]", "NudC domain-containing protein 1 [IPR037895]", "NudC family [IPR037898]", "OBG-type GTPase [IPR045086]", "OCIA domain-containing protein 1/2 [IPR040187]", "ORC ubiquitin ligase 1 [IPR039209]", "Oligoribonuclease [IPR022894]", "Oligosaccharyl transferase complex, subunit OST3/OST6 [IPR021149]", "Oligosaccharyl transferase, STT3 subunit [IPR003674]", "Origin recognition complex, subunit 2 [IPR007220]", "Origin recognition complex, subunit 3 [IPR020795]", "Origin recognition complex, subunit 5 [IPR020796]", "Ornithine aminotransferase [IPR010164]", "Orotate phosphoribosyltransferase [IPR023031]", "Orotidine 5'-phosphate decarboxylase [IPR014732]", "Oxidized purine nucleoside triphosphate [IPR003563]", "Oxysterol-binding protein [IPR000648]", "P-type ATPase [IPR001757]", "P-type ATPase subfamily IIC, subunit alpha [IPR005775]", "P-type ATPase, subfamily IIA, SERCA-type [IPR005782]", "P-type ATPase, subfamily V [IPR006544]", "P-type ATPase, subfamily IIB [IPR006408]", "P-type ATPase, subfamily IV [IPR006539]", "PA2G4 family [IPR004545]", "PAT complex subunit CCDC47 [IPR012879]", "PCNA-associated factor [IPR040444]", "PDCD5-like [IPR002836]", "PDK/BCKDK protein kinase [IPR039028]", "PDZ and LIM domain protein 1 [IPR028537]", "PEST proteolytic signal-containing nuclear protein [IPR029169]", "PH-interacting protein [IPR028738]", "PHF5-like [IPR005345]", "PITH domain-containing protein 1-like [IPR045099]", "PP2B [IPR043360]", "Pachytene checkpoint protein 2-like [IPR044539]", "Palmitoyl protein thioesterase [IPR002472]", "Palmitoyl-protein thioesterase 1 [IPR030294]", "Pantothenate kinase, acetyl-CoA regulated, two-domain type [IPR015844]", "Paraneoplastic antigen Ma [IPR026523]", "Paraneoplastic encephalomyelitis antigen [IPR002343]", "Paraoxonase2 [IPR008364]", "Partner of Y14 and mago [IPR039333]", "Pentatricopeptide repeat domain-containing protein 3 [IPR037387]", "Peptidase A22B, signal peptide peptidase [IPR007369]", "Peptidase C13, legumain [IPR001096]", "Peptidase C1B, bleomycin hydrolase [IPR004134]", "Peptidase C2, calpain family [IPR022684]", "Peptidase C26 [IPR011697]", "Peptidase C26, gamma-glutamyl hydrolase [IPR015527]", "Peptidase C65, otubain [IPR019400]", "Peptidase C69, dipeptidase A [IPR005322]", "Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930]", "Peptidase M1, aminopeptidase B [IPR015571]", "Peptidase M13 [IPR000718]", "Peptidase M14B, caboxypeptidase D [IPR015567]", "Peptidase M17, leucine aminopeptidase [IPR023042]", "Peptidase M17, leucine aminopeptidase/peptidase B [IPR011356]", "Peptidase M20 [IPR002933]", "Peptidase M28 family [IPR045175]", "Peptidase M3A/M3B [IPR045090]", "Peptidase S10, serine carboxypeptidase [IPR001563]", "Peptidase S1A, chymotrypsin family [IPR001314]", "Peptidase S26B [IPR001733]", "Peptidase S28 [IPR008758]", "Peptidase S8, subtilisin-related [IPR015500]", "Peptidase S9A, prolyl oligopeptidase [IPR002470]", "Peptidase T1A, proteasome beta-subunit [IPR000243]", "Peptidase family M49 [IPR039461]", "Peptidase, FtsH [IPR005936]", "Peptide chain release factor eRF1/aRF1 [IPR004403]", "Peptidyl-prolyl cis-trans isomerase FKBP2/11 [IPR044609]", "Peptidyl-prolyl cis-trans isomerase FKBP3 [IPR043368]", "Peptidyl-prolyl cis-trans isomerase FKBP4 [IPR031212]", "Peptidyl-prolyl cis-trans isomerase FKBP5 [IPR031210]", "Peptidyl-prolyl cis-trans isomerase PIN4 [IPR043323]", "Peptidyl-tRNA hydrolase, PTH2 [IPR002833]", "Pericentriolar material 1 protein [IPR024138]", "Perilipin [IPR004279]", "Periodic tryptophan protein 1 [IPR044285]", "Periodic tryptophan protein 2 [IPR027145]", "Peroxiredoxin, AhpC-type [IPR024706]", "Peroxiredoxin-5-like [IPR037944]", "Peroxiredoxin-like 2A [IPR032802]", "Peroxiredoxin-like 2A/B/C [IPR032801]", "Peroxisomal acyl-coenzyme A oxidase [IPR034171]", "Peroxisomal membrane protein 14 [IPR025655]", "Peroxysomal long chain fatty acyl transporter [IPR005283]", "Pescadillo [IPR010613]", "Pex19 protein [IPR006708]", "Phenylalanine-tRNA ligase, class IIc, beta subunit [IPR045060]", "Phenylalanyl-tRNA synthetase, class IIc, alpha subunit [IPR004529]", "Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archael/eukaryotic type [IPR004531]", "Phosducin-like [IPR045037]", "Phosphatase Gpp1/Gpp2-like [IPR045228]", "Phosphatidate cytidylyltransferase [IPR000374]", "Phosphatidate cytidylyltransferase, eukaryota [IPR016720]", "Phosphatidate cytidylyltransferase, mitochondrial [IPR015222]", "Phosphatidylethanolamine-binding protein [IPR008914]", "Phosphatidylethanolamine-binding protein, eukaryotic [IPR035810]", "Phosphatidylinositol kinase [IPR015433]", "Phosphatidylinositol transfer protein [IPR001666]", "Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma [IPR016279]", "Phosphatidylinositol-binding clathrin assembly protein [IPR030412]", "Phosphatidylinositol-glycan biosynthesis class S protein [IPR019540]", "Phosphoacetylglucosamine mutase [IPR016657]", "Phosphodiesterase MJ0936/Vps29 [IPR000979]", "Phosphoenolpyruvate carboxykinase, GTP-utilising [IPR008209]", "Phosphoglucomutase [IPR045244]", "Phosphoglucose isomerase (PGI) [IPR001672]", "Phosphoglycerate kinase [IPR001576]", "Phosphoglycerate mutase 1 [IPR005952]", "Phosphoinositide phospholipase C family [IPR001192]", "Phospholipase B-like [IPR007000]", "Phospholipid-transporting ATPase IG [IPR030363]", "Phosphoribosylformylglycinamidine cyclo-ligase [IPR004733]", "Phosphoribosylformylglycinamidine synthase PurL [IPR010073]", "Phosphoribosylglycinamide formyltransferase [IPR004607]", "Phosphoribosylglycinamide synthetase [IPR000115]", "Phosphorylated adapter RNA export protein [IPR039047]", "Phosphoserine aminotransferase [IPR022278]", "Phosphotyrosyl phosphatase activator, PTPA [IPR004327]", "Pinin [IPR039853]", "Pirin [IPR012093]", "Plakin [IPR043197]", "Plakophilin/Delta catenin [IPR028435]", "Plasma membrane calcium-transporting ATPase 1 [IPR030320]", "Plasminogen activator inhibitor 1 RNA-binding protein [IPR027205]", "Plastin-1 [IPR030235]", "Plastin-2/3 [IPR039956]", "Plectin [IPR030269]", "Podocalyxin [IPR017403]", "Polo kinase kinase [IPR022165]", "Poly(A) polymerase [IPR014492]", "Poly-U binding splicing factor, PUF60-like [IPR006532]", "Polyadenylate binding protein, human types 1, 2, 3, 4 [IPR006515]", "Polyadenylate-binding protein 2 [IPR034911]", "Polyadenylate-binding protein-interacting protein 2-like [IPR040396]", "Polyprenyl synthetase [IPR000092]", "Polyribonucleotide 5-hydroxyl-kinase Clp1/Grc3 [IPR045116]", "Polyribonucleotide nucleotidyltransferase [IPR012162]", "Porin, eukaryotic type [IPR001925]", "Porphobilinogen deaminase [IPR000860]", "Pre-mRNA 3' end processing protein Pfs2-like [IPR045245]", "Pre-mRNA-processing factor 19 [IPR038959]", "Pre-mRNA-processing factor 6/Prp1/STA1 [IPR027108]", "Pre-mRNA-processing factor Prp40 [IPR039726]", "Pre-mRNA-processing-splicing factor 8 [IPR027652]", "Pre-mRNA-splicing factor Cwf15/Cwc15 [IPR006973]", "Pre-mRNA-splicing factor 38 [IPR005037]", "Pre-mRNA-splicing factor Cwc2/Slt11 [IPR039171]", "Pre-mRNA-splicing factor SPF27 [IPR008409]", "Pre-mRNA-splicing factor Syf1-like [IPR045075]", "Pre-mRNA-splicing regulator WTAP [IPR033757]", "Pre-rRNA-processing protein Esf1 [IPR039754]", "Pre-rRNA-processing protein PNO1-like [IPR039912]", "Prefoldin alpha subunit, archaea-type [IPR011599]", "Prefoldin alpha-like [IPR004127]", "Prefoldin beta-like [IPR002777]", "Prefoldin subunit 2 [IPR027235]", "Prefoldin subunit 3 [IPR016655]", "Prefoldin, subunit 4 [IPR016661]", "Prenylated rab acceptor PRA1 [IPR004895]", "Prenylcysteine oxidase [IPR017046]", "Prenyltransferase subunit beta [IPR045089]", "Presenilin/signal peptide peptidase [IPR006639]", "Primosome PriB/single-strand DNA-binding [IPR000424]", "Probable E3 ubiquitin-protein ligase makorin-2 [IPR026293]", "Probable ubiquitin carboxyl-terminal hydrolase FAF-X [IPR031226]", "Profilin [IPR005455]", "Profilin-1 [IPR029892]", "Profilin-2 [IPR029891]", "Profilin1/2/3, vertebrate [IPR005454]", "Progesterone-induced-blocking factor 1 [IPR026205]", "Programmed cell death protein 4 [IPR039778]", "Prohibitin [IPR000163]", "Proliferating cell nuclear antigen, PCNA [IPR000730]", "Proline-rich protein PRCC [IPR018800]", "Proline-tRNA ligase, class IIa, archaeal-type [IPR004499]", "Prolyl 3-hydroxylase 1 [IPR039837]", "Prolyl 3-hydroxylase [IPR039575]", "Prolyl 4-hydroxylase [IPR045054]", "Prostaglandin E synthase 2 [IPR034334]", "Prostaglandin reductase 2 [IPR037399]", "Prostate apoptosis response 4 [IPR026117]", "Proteasomal ubiquitin receptor Rpn13/ADRM1 [IPR006773]", "Proteasome B-type subunit [IPR023333]", "Proteasome activator PA28 [IPR009077]", "Proteasome activator complex subunit 4 [IPR035309]", "Proteasome alpha-type subunit [IPR023332]", "Proteasome assembly chaperone 1 [IPR016565]", "Proteasome beta 3 subunit [IPR033811]", "Proteasome component Ecm29 [IPR024372]", "Proteasome subunit alpha 1 [IPR035144]", "Proteasome subunit alpha 3 [IPR037555]", "Proteasome subunit alpha 7 [IPR035190]", "Proteasome subunit alpha2 [IPR034644]", "Proteasome subunit alpha4 [IPR034647]", "Proteasome subunit alpha5 [IPR033812]", "Proteasome subunit alpha6 [IPR034642]", "Proteasome subunit beta 1 [IPR035202]", "Proteasome subunit beta 2 [IPR035206]", "Proteasome subunit beta 4 [IPR016295]", "Proteasome subunit beta 5 [IPR037558]", "Proteasome subunit beta 6 [IPR035140]", "Proteasome subunit beta 7 [IPR035216]", "Proteasome, subunit alpha/beta [IPR001353]", "Protein AATF/Bfr2 [IPR039223]", "Protein CDV3 [IPR026806]", "Protein CIP2A [IPR042510]", "Protein CUSTOS [IPR026694]", "Protein Cms1 [IPR032704]", "Protein DEK [IPR044198]", "Protein ERGIC-53 [IPR033085]", "Protein FAM8A1 [IPR039871]", "Protein FRG1 [IPR010414]", "Protein ICln/Lot5/Saf5 [IPR039924]", "Protein LCHN/Anr2 [IPR018626]", "Protein LYRIC [IPR031402]", "Protein Lsm12-like [IPR039683]", "Protein NDRG3 [IPR030692]", "Protein PBDC1, metazoa/fungi [IPR008476]", "Protein PRRC1 [IPR026534]", "Protein PRRC2 [IPR033184]", "Protein Peter Pan-like [IPR045112]", "Protein RCC2 [IPR028641]", "Protein Red-like [IPR039896]", "Protein S100-A11 [IPR028482]", "Protein SON [IPR032922]", "Protein Sec13 [IPR037596]", "Protein Sgt1-like [IPR044563]", "Protein TFG [IPR033512]", "Protein Yip1/4-like [IPR045231]", "Protein arginine N-methyltransferase PRMT5 [IPR007857]", "Protein arginine N-methyltransferase [IPR025799]", "Protein canopy homolog [IPR042415]", "Protein disulfide-isomerase A6-like [IPR044569]", "Protein disulphide isomerase [IPR005792]", "Protein disulphide-isomerase A4 [IPR017068]", "Protein farnesyltransferase subunit beta [IPR026872]", "Protein flightless-1 [IPR029919]", "Protein furry/Tao3/Mor2 [IPR039867]", "Protein import receptor MAS20 [IPR002056]", "Protein import receptor MAS20, metazoan [IPR022422]", "Protein jagunal [IPR009787]", "Protein kinase C and casein kinase substrate in neurons protein 2 [IPR028521]", "Protein kinase C and casein kinase substrate in neurons protein 3 [IPR028523]", "Protein kinase C, alpha/beta/gamma types [IPR014375]", "Protein kinase C-binding protein 1 [IPR021931]", "Protein kish [IPR009653]", "Protein of unknown function DUF1075 [IPR009432]", "Protein of unknown function DUF2046 [IPR019152]", "Protein of unknown function DUF719 [IPR007998]", "Protein patched/dispatched [IPR003392]", "Protein phosphatase 1 regulatory subunit 12A/B/C [IPR017401]", "Protein phosphatase 2A regulatory subunit PR55 [IPR000009]", "Protein phosphatase 2A, regulatory B subunit, B56 [IPR002554]", "Protein phosphatase 2C family [IPR015655]", "Protein regulator of cytokinesis 1 [IPR032921]", "Protein strawberry notch [IPR026741]", "Protein transport Sec61-beta/Sbh [IPR030671]", "Protein transport protein SEC31-like [IPR040251]", "Protein transport protein Sec23 [IPR037364]", "Protein transport protein SecG/Sec61-beta/Sbh [IPR016482]", "Protein unc-119 homologue A-like [IPR032977]", "Protein virilizer [IPR026736]", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase [IPR000682]", "Protein-S-isoprenylcysteine O-methyltransferase [IPR025770]", "Protein-glutamate O-methyltransferase [IPR039763]", "Protein-tyrosine phosphatase, low molecular weight [IPR017867]", "Protein-tyrosine phosphatase, low molecular weight, mammalian [IPR002115]", "Protein-tyrosine phosphatase, non-receptor type-1/2 [IPR012265]", "Protein-tyrosine phosphatase, non-receptor type-6, -11 [IPR012152]", "Protein-tyrosine phosphatase-like, PTPLA [IPR007482]", "Protein/nucleic acid deglycase DJ-1 [IPR006287]", "Proteinase inhibitor I25A, stefin [IPR001713]", "Protoporphyrinogen oxidase [IPR004572]", "Pseudouridine synthase, TruD [IPR001656]", "Pterin 4 alpha carbinolamine dehydratase [IPR001533]", "Pumilio homologue 3 [IPR040059]", "Purine 5'-nucleotidase [IPR016695]", "Purine nucleoside phosphorylase I, inosine/guanosine-specific [IPR011270]", "Purine nucleoside phosphorylase [IPR011268]", "Purine-rich element binding protein family [IPR006628]", "Purine-rich element-binding protein alpha [IPR030500]", "Pyridine nucleotide-disulphide oxidoreductase, class I [IPR001100]", "Pyridoxal phosphate-dependent decarboxylase [IPR002129]", "Pyrimidine 5'-nucleotidase, eukaryotic [IPR006434]", "Pyrroline-5-carboxylate reductase [IPR000304]", "Pyruvate carboxylase [IPR005930]", "Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y [IPR017597]", "Pyruvate dehydrogenase E1 component subunit beta [IPR027110]", "Pyruvate kinase [IPR001697]", "RAD3/XPD family [IPR001945]", "RLI1 [IPR013283]", "RNA (C5-cytosine) methyltransferase [IPR023267]", "RNA (C5-cytosine) methyltransferase, NOP2 [IPR023273]", "RNA 3'-terminal phosphate cyclase [IPR000228]", "RNA 3'-terminal phosphate cyclase type 2 [IPR016443]", "RNA binding protein HABP4/SERBP1 [IPR039764]", "RNA cytidine acetyltransferase NAT10 [IPR033688]", "RNA demethylase ALKBH5 [IPR032860]", "RNA exonuclease 4 [IPR034920]", "RNA polymerase I associated factor, A49-like [IPR009668]", "RNA polymerase II associated factor Paf1 [IPR007133]", "RNA polymerase II transcriptional coactivator Sub1/Tcp4-like [IPR045125]", "RNA polymerase subunit Rpb4/RPC9 [IPR005574]", "RNA polymerase subunit Rpb7-like [IPR045113]", "RNA polymerase, Rpb8 [IPR005570]", "RNA polymerase-associated protein Ctr9 [IPR031101]", "RNA transcription, translation and transport factor protein [IPR019265]", "RNA-binding motif protein 8 [IPR008111]", "RNA-binding protein 10 [IPR033095]", "RNA-binding protein 26 [IPR034861]", "RNA-binding protein 26/27 [IPR045137]", "RNA-binding protein 45 [IPR033101]", "RNA-binding protein 5 [IPR033094]", "RNA-binding protein EWS [IPR033109]", "RNA-binding protein FUS [IPR034459]", "RNA-binding protein NOB1 [IPR039907]", "RNA-binding protein Nova-2 [IPR033087]", "RNA-induced silencing complex, nuclease component Tudor-SN [IPR016685]", "RNA-splicing ligase RtcB homologue, eukaryotic [IPR027513]", "RNA-splicing ligase, RtcB [IPR001233]", "RNase P subunit p30 [IPR002738]", "RPA-related protein RADX [IPR040893]", "RZZ complex, subunit Zw10 [IPR009361]", "Rab GDI protein [IPR000806]", "Rab GTPase-activating protein 1 [IPR033185]", "Rab21 [IPR041833]", "Rab3 [IPR037872]", "Rab35 [IPR041815]", "Rab3GAP catalytic subunit [IPR045700]", "Rab3GAP regulatory subunit [IPR026059]", "Rab4 [IPR041819]", "Rab9 [IPR041824]", "Rad21/Rec8-like protein [IPR039781]", "RalBP1-associated Eps domain-containing protein 1 [IPR026814]", "Ran GTPase [IPR002041]", "Ran binding protein RanBP1-like [IPR045255]", "Rap guanine nucleotide exchange factor 2 [IPR030739]", "Rap1 GTPase-GDP dissociation stimulator 1 [IPR040144]", "Ras GTPase GNL1-like [IPR043358]", "Ras GTPase-activating protein [IPR039360]", "Ras GTPase-activating protein-binding protein 1 [IPR034375]", "Ras GTPase-activating protein-binding protein 2 [IPR034377]", "Ras GTPase-activating protein-binding protein [IPR039539]", "Ras-like guanine nucleotide exchange factor [IPR008937]", "Ras-related protein Rab-23 [IPR034114]", "Ras-related protein Rab14 [IPR030702]", "Ras-related protein Ral [IPR028412]", "Remodeling and spacing factor 1-like [IPR028938]", "Remodelling complex subunit Rsc/polybromo [IPR037382]", "Replication factor A protein 1 [IPR004591]", "Replication factor A protein 2 [IPR014646]", "Replication factor A protein-like [IPR040260]", "Replication factor C subunit 1 [IPR012178]", "Replication termination factor 2 [IPR006735]", "Reticulon-4-interacting protein 1 [IPR037397]", "Reticulophagy receptor 1/3 [IPR043384]", "Reticulophagy regulator 3 [IPR033361]", "Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit [IPR017287]", "Retinoblastoma-binding protein 5/Swd1 [IPR037850]", "Retrieval of early ER protein Rer1 [IPR004932]", "Rho protein GDP-dissociation inhibitor [IPR000406]", "Rho-associated protein kinase 1/2 [IPR020684]", "Rho-related GTP-binding protein RhoG [IPR042734]", "Ribonuclease CAF1 [IPR006941]", "Ribonuclease H2 subunit B [IPR040456]", "Ribonuclease H2, subunit A [IPR004649]", "Ribonuclease HII/HIII [IPR001352]", "Ribonuclease III [IPR011907]", "Ribonuclease Nob1, eukaryote [IPR017117]", "Ribonuclease T2, eukaryotic [IPR033697]", "Ribonuclease T2-like [IPR001568]", "Ribonucleases P/MRP protein subunit Pop1 [IPR039182]", "Ribonucleases P/MRP protein subunit Rpp20/Pop7 [IPR014612]", "Ribonucleoprotein PTB-binding 1 [IPR034635]", "Ribonucleoside-diphosphate reductase large subunit [IPR039718]", "Ribonucleotide reductase small subunit [IPR033909]", "Ribonucleotide reductase small subunit family [IPR000358]", "Ribophorin I [IPR007676]", "Ribose-phosphate pyrophosphokinase [IPR005946]", "Ribosomal RNA adenine dimethylase [IPR011530]", "Ribosomal RNA adenine methyltransferase KsgA/Erm [IPR001737]", "Ribosomal RNA assembly KRR1 [IPR024166]", "Ribosomal RNA large subunit methyltransferase E [IPR015507]", "Ribosomal RNA processing protein 8 [IPR007823]", "Ribosomal RNA-processing protein 15 [IPR012459]", "Ribosomal RNA-processing protein Rrp9-like [IPR039241]", "Ribosomal biogenesis NSA2 family [IPR039411]", "Ribosomal biogenesis regulatory protein [IPR007023]", "Ribosomal biogenesis, methyltransferase, EMG1/NEP1 [IPR005304]", "Ribosomal protein L1 [IPR002143]", "Ribosomal protein L1, mitochondrial [IPR005879]", "Ribosomal protein L1/ribosomal biogenesis protein [IPR028364]", "Ribosomal protein L10P [IPR001790]", "Ribosomal protein L10e [IPR001197]", "Ribosomal protein L11, bacterial-type [IPR006519]", "Ribosomal protein L11/L12 [IPR000911]", "Ribosomal protein L12/P1/P2 family [IPR027534]", "Ribosomal protein L13 [IPR005822]", "Ribosomal protein L13, bacterial-type [IPR005823]", "Ribosomal protein L13, eukaryotic/archaeal [IPR005755]", "Ribosomal protein L13e [IPR001380]", "Ribosomal protein L14 [IPR039660]", "Ribosomal protein L14P [IPR000218]", "Ribosomal protein L15 [IPR030878]", "Ribosomal protein L15, bacterial-type [IPR005749]", "Ribosomal protein L15e [IPR000439]", "Ribosomal protein L17 [IPR000456]", "Ribosomal protein L18e [IPR000039]", "Ribosomal protein L19 [IPR001857]", "Ribosomal protein L2 [IPR002171]", "Ribosomal protein L2, archaeal-type [IPR023672]", "Ribosomal protein L20 [IPR005813]", "Ribosomal protein L21 [IPR001787]", "Ribosomal protein L21-like [IPR028909]", "Ribosomal protein L21e [IPR001147]", "Ribosomal protein L22/L17 [IPR001063]", "Ribosomal protein L22/L17, eukaryotic/archaeal [IPR005721]", "Ribosomal protein L22e [IPR002671]", "Ribosomal protein L23 [IPR019985]", "Ribosomal protein L24 [IPR003256]", "Ribosomal protein L24e [IPR023438]", "Ribosomal protein L24e-related [IPR000988]", "Ribosomal protein L25/L23 [IPR013025]", "Ribosomal protein L26/L24, eukaryotic/archaeal [IPR005756]", "Ribosomal protein L27/L41, mitochondrial [IPR019189]", "Ribosomal protein L27e [IPR001141]", "Ribosomal protein L28/L24 [IPR026569]", "Ribosomal protein L28/L40, mitochondrial [IPR019192]", "Ribosomal protein L28e [IPR002672]", "Ribosomal protein L29/L35 [IPR001854]", "Ribosomal protein L29e [IPR002673]", "Ribosomal protein L3 [IPR000597]", "Ribosomal protein L3, archaeal/eukaryotic type [IPR045077]", "Ribosomal protein L3, bacterial/organelle-type [IPR019927]", "Ribosomal protein L30/YlxQ [IPR039109]", "Ribosomal protein L30e [IPR000231]", "Ribosomal protein L31e [IPR000054]", "Ribosomal protein L32e [IPR001515]", "Ribosomal protein L34Ae [IPR008195]", "Ribosomal protein L35A [IPR001780]", "Ribosomal protein L36e [IPR000509]", "Ribosomal protein L37/S30 [IPR010793]", "Ribosomal protein L37ae [IPR002674]", "Ribosomal protein L37e [IPR001569]", "Ribosomal protein L38e [IPR002675]", "Ribosomal protein L4, eukaryotic and archaeal type [IPR045240]", "Ribosomal protein L4/L1e [IPR002136]", "Ribosomal protein L44e [IPR000552]", "Ribosomal protein L47, mitochondrial [IPR010729]", "Ribosomal protein L5 [IPR002132]", "Ribosomal protein L5 eukaryotic/L18 archaeal [IPR005485]", "Ribosomal protein L51, mitochondrial [IPR019373]", "Ribosomal protein L53, mitochondrial [IPR019716]", "Ribosomal protein L6 [IPR000702]", "Ribosomal protein L7, eukaryotic [IPR005998]", "Ribosomal protein L7/L12 [IPR000206]", "Ribosomal protein L7/L30 [IPR039699]", "Ribosomal protein L7A/L8 [IPR001921]", "Ribosomal protein L7Ae/L8/Nhp2 family [IPR018492]", "Ribosomal protein L9 [IPR000244]", "Ribosomal protein P2 [IPR044076]", "Ribosomal protein S10 [IPR001848]", "Ribosomal protein S10, eukaryotic/archaeal [IPR005729]", "Ribosomal protein S11 [IPR001971]", "Ribosomal protein S12/S23 [IPR006032]", "Ribosomal protein S12e [IPR000530]", "Ribosomal protein S13 [IPR001892]", "Ribosomal protein S15 [IPR000589]", "Ribosomal protein S15, bacterial-type [IPR005290]", "Ribosomal protein S15P [IPR023029]", "Ribosomal protein S17, archaeal/eukaryotic [IPR028333]", "Ribosomal protein S17/S11 [IPR000266]", "Ribosomal protein S17e [IPR001210]", "Ribosomal protein S19/S15 [IPR002222]", "Ribosomal protein S19A/S15e [IPR005713]", "Ribosomal protein S19e [IPR001266]", "Ribosomal protein S2 [IPR001865]", "Ribosomal protein S2, bacteria/mitochondria/plastid [IPR005706]", "Ribosomal protein S2, eukaryotic [IPR027498]", "Ribosomal protein S2, eukaryotic/archaeal [IPR005707]", "Ribosomal protein S22, mitochondrial [IPR019374]", "Ribosomal protein S23, eukaryotic/archaeal [IPR005680]", "Ribosomal protein S23, mitochondrial [IPR019520]", "Ribosomal protein S23/S29, mitochondrial [IPR019368]", "Ribosomal protein S24/S35, mitochondrial [IPR039848]", "Ribosomal protein S24e [IPR001976]", "Ribosomal protein S25 [IPR004977]", "Ribosomal protein S26e [IPR000892]", "Ribosomal protein S28, mitochondrial [IPR019375]", "Ribosomal protein S28e [IPR000289]", "Ribosomal protein S29, mitochondrial [IPR008092]", "Ribosomal protein S3, eukaryotic/archaeal [IPR005703]", "Ribosomal protein S30 [IPR006846]", "Ribosomal protein S30, mitochondrial [IPR039982]", "Ribosomal protein S3Ae [IPR001593]", "Ribosomal protein S4/S9 [IPR022801]", "Ribosomal protein S4/S9, eukaryotic/archaeal [IPR005710]", "Ribosomal protein S4e [IPR000876]", "Ribosomal protein S5 [IPR000851]", "Ribosomal protein S5, eukaryotic/archaeal [IPR005711]", "Ribosomal protein S5/S7 [IPR000235]", "Ribosomal protein S5/S7, eukaryotic/archaeal [IPR005716]", "Ribosomal protein S6 kinase II [IPR016239]", "Ribosomal protein S6, eukaryotic [IPR014401]", "Ribosomal protein S6e [IPR001377]", "Ribosomal protein S7e [IPR000554]", "Ribosomal protein S8 [IPR000630]", "Ribosomal protein S8e [IPR001047]", "Ribosomal protein S8e/ribosomal biogenesis NSA2 [IPR022309]", "Ribosomal protein S9 [IPR000754]", "Ribosome assembly factor Mrt4 [IPR033867]", "Ribosome biogenesis factor, NIP7 [IPR016686]", "Ribosome biogenesis protein BRX1 [IPR026532]", "Ribosome biogenesis protein Bms1/Tsr1 [IPR039761]", "Ribosome biogenesis protein Nop16 [IPR019002]", "Ribosome biogenesis protein Rpf2 [IPR039770]", "Ribosome maturation protein Sdo1/SBDS [IPR002140]", "Ribosome maturation protein Sdo1/SBDS-like [IPR039100]", "Ribosome-binding ATPase YchF/Obg-like ATPase 1 [IPR004396]", "Ribosome-binding protein 1 [IPR040248]", "RidA family [IPR006056]", "Rieske iron-sulphur protein [IPR014349]", "RuvB-like [IPR027238]", "RuvB-like helicase 1 [IPR037938]", "RuvB-like helicase 2 [IPR037942]", "S-adenosylmethionine synthetase [IPR002133]", "S-formylglutathione hydrolase [IPR014186]", "S-phase kinase-associated protein 1 [IPR016897]", "S-phase kinase-associated protein 1-like [IPR001232]", "SAC3/GANP/THP3 [IPR045107]", "SAFB-like transcription modulator [IPR034780]", "SAP30-binding protein [IPR012479]", "SAPAP family [IPR005026]", "SCAMP [IPR007273]", "SERRATE/Ars2 [IPR039727]", "SH3-binding, glutamic acid-rich protein [IPR006993]", "SIT4 phosphatase-associated protein family [IPR007587]", "SKI-interacting protein, SKIP [IPR017862]", "SLC12A transporter family [IPR004842]", "SNF5/SMARCB1/INI1 [IPR006939]", "SNU66/SART1 family [IPR005011]", "SNX17/27/31 [IPR037831]", "SOS response associated peptidase (SRAP) [IPR003738]", "SOUL haem-binding protein [IPR006917]", "SUMO-activating enzyme subunit Uba2 [IPR030661]", "SUN domain-containing protein 1 [IPR018539]", "SUN domain-containing protein 1-5 [IPR045119]", "SUN domain-containing protein 2 [IPR030272]", "SURP and G-patch domain-containing protein 1/2 [IPR040169]", "SWI/SNF complex subunit BAF57 [IPR030089]", "SWI/SNF complex subunit BRG1 [IPR030100]", "SWI/SNF complex subunit SMARCC1 [IPR030087]", "SWI/SNF complex subunit SMARCC2 [IPR038044]", "SWI/SNF-like complex subunit BAF250a [IPR030094]", "SWI/SNF-like complex subunit BAF250/Osa [IPR021906]", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [IPR038041]", "SWR1-complex protein 5/Craniofacial development protein 1/2 [IPR027124]", "Saposin [IPR008373]", "Saposin, chordata [IPR021165]", "Sas10/Utp3/C1D [IPR007146]", "Scaffold attachment factor B1 [IPR034781]", "Scaffold attachment factor B2 [IPR034782]", "Scavenger mRNA decapping enzyme DcpS/DCS2 [IPR008594]", "Scc2/Nipped-B family [IPR033031]", "Schlafen family [IPR029684]", "Sda1 [IPR027312]", "Sec1-like protein [IPR001619]", "Sec13/Seh1 family [IPR037363]", "Sec20 [IPR005606]", "SecY/SEC61-alpha family [IPR002208]", "Selenium-binding protein [IPR008826]", "Selenophosphate synthetase [IPR004536]", "Sentrin-specific protease 3 [IPR037945]", "Sepiapterin reductase [IPR006393]", "Septin 2 [IPR008113]", "Septin 7 [IPR008115]", "Septin 9 [IPR030645]", "Septin [IPR016491]", "Septin and tuftelin interacting protein [IPR024933]", "Serine hydroxymethyltransferase [IPR001085]", "Serine-tRNA ligase, type1 [IPR002317]", "Serine/arginine-rich splicing factor 10 [IPR034476]", "Serine/arginine-rich splicing factor 11 [IPR034447]", "Serine/arginine-rich splicing factor 6 [IPR029541]", "Serine/threonine protein phosphatase 5 [IPR011236]", "Serine/threonine-protein kinase PAK2 [IPR035065]", "Serine/threonine-protein kinase TOR [IPR026683]", "Serine/threonine-protein kinase Vps15-like [IPR045162]", "Serine/threonine-protein phosphatase 2A subunit A, metazoa [IPR031090]", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit [IPR037979]", "Serpin H1 [IPR033547]", "Serpin family [IPR000215]", "Shootin-1 [IPR024849]", "Short transmembrane mitochondrial protein 1 [IPR027854]", "Short-chain dehydrogenase/reductase SDR [IPR002347]", "Sideroflexin-4 [IPR028825]", "Sigma intracellular receptor 2 [IPR016964]", "Signal peptidase complex catalytic subunit SEC11A [IPR037712]", "Signal peptidase complex subunit 3 [IPR007653]", "Signal peptidase complex subunit Spc2/SPCS2 [IPR009582]", "Signal recognition particle SRP9 [IPR039914]", "Signal recognition particle receptor, beta subunit [IPR019009]", "Signal recognition particle subunit SRP68 [IPR026258]", "Signal recognition particle, SRP14 subunit [IPR003210]", "Signal recognition particle, SRP54 subunit [IPR022941]", "Signal recognition particle, SRP54 subunit, eukaryotic [IPR006325]", "Signal recognition particle, SRP72 subunit [IPR026270]", "Signal recognition particle, SRP9 subunit [IPR008832]", "Sin3 associated polypeptide p18 [IPR010516]", "Single-stranded DNA-binding protein [IPR011344]", "Sirtuin family [IPR003000]", "Sirtuin, class I [IPR017328]", "Sister chromatid cohesion protein Pds5 [IPR039776]", "Ski3/TTC37 [IPR039226]", "Sm-like protein Lsm6/SmF [IPR016487]", "Sm-like protein Lsm7 [IPR017132]", "Sm-like protein Lsm7/SmG [IPR044641]", "Smac/DIABLO protein [IPR015142]", "Small (40S) ribosomal subunit Asc1/RACK1 [IPR045223]", "Small GTPase Rho [IPR003578]", "Small GTPase [IPR001806]", "Small GTPase superfamily, ARF type [IPR024156]", "Small GTPase superfamily, ARF/SAR type [IPR006689]", "Small GTPase superfamily, SAR1-type [IPR006687]", "Small GTPase, Ras-type [IPR020849]", "Small acidic protein [IPR026714]", "Small nuclear ribonucleoprotein E [IPR027078]", "Small nuclear ribonucleoprotein Sm D2 [IPR027248]", "Small nuclear ribonucleoprotein Sm D3 [IPR034099]", "Small-subunit processome, Utp11 [IPR007144]", "Small-subunit processome, Utp14 [IPR006709]", "Smooth muscle protein/calponin [IPR003096]", "Snapin [IPR017246]", "Snapin/Pallidin/Snn1 [IPR028119]", "Snf7 family [IPR005024]", "Sodium/potassium-transporting ATPase subunit beta [IPR000402]", "Sodium/potassium-transporting ATPase subunit beta, chordates [IPR015565]", "Sodium:dicarboxylate symporter [IPR001991]", "Solute carrier family 12 member 1/2 [IPR002443]", "Solute carrier family 12 member 2 [IPR002444]", "Solute carrier family 35 member SLC35F1/F2/F6 [IPR009262]", "Sorbitol dehydrogenase-like [IPR045306]", "Sorting nexin 9 family [IPR014536]", "Sorting nexin-1 [IPR028660]", "Sorting nexin-2 [IPR028653]", "Sorting nexin-27 [IPR028667]", "Sorting nexin-5 [IPR028654]", "Sorting nexin-5/6/32 [IPR014637]", "Sorting nexin-6 [IPR028657]", "Sorting nexin-9 [IPR028644]", "Spartin-like [IPR045036]", "Spectrin, beta subunit [IPR016343]", "Sperm-associated antigen 5 [IPR028728]", "Spermatid perinuclear RNA-binding protein [IPR030446]", "Spermidine/spermine synthase, eukaryotes [IPR030668]", "Spermidine/spermine synthases [IPR001045]", "Sphingomyelin phosphodiesterase 4 [IPR024129]", "Sphingosine N-acyltransferase Lag1/Lac1-like [IPR016439]", "Splicing factor 3A subunit 1 [IPR045146]", "Splicing factor 3A subunit 3 [IPR031776]", "Splicing factor 3B subunit 1-like [IPR038737]", "Splicing factor 45 [IPR040052]", "Splicing factor ELAV/Hu [IPR006548]", "Splicing factor, RBM39-like [IPR006509]", "Splicing factor, arginine/serine-rich 19 [IPR042841]", "Squalene cyclase [IPR018333]", "Squalene monooxygenase [IPR040125]", "Squalene synthase-like [IPR006449]", "Squalene/phytoene synthase [IPR002060]", "Stathmin family [IPR000956]", "Steroidogenic acute regulatory protein-like [IPR000799]", "Sterol transport protein NPC2-like [IPR039670]", "Stomatin/HflK/HflC family [IPR001972]", "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 [IPR038892]", "Structural maintenance of chromosomes protein 1A, metazoan [IPR029683]", "Structural maintenance of chromosomes protein 5 [IPR027131]", "Structural maintenance of chromosomes protein [IPR024704]", "Structure-specific recognition protein [IPR000969]", "Succinate dehydrogenase, flavoprotein subunit [IPR011281]", "Succinate dehydrogenase/fumarate reductase iron-sulphur protein [IPR004489]", "Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [IPR014006]", "Succinate semialdehyde dehydrogenase [IPR010102]", "Succinate--CoA synthetase, beta subunit [IPR005809]", "Succinyl-CoA ligase, alpha subunit [IPR005810]", "Sugar/inositol transporter [IPR003663]", "Sulfhydryl oxidase [IPR039798]", "Sulfotransferase [IPR005331]", "Sulfurtransferase TST/MPST-like [IPR045078]", "Suppressor of hairless-like [IPR040159]", "Suppressor of white apricot [IPR040397]", "Surface antigen D15-like [IPR039910]", "Surfeit locus 1/4 [IPR045214]", "Surfeit locus 4 [IPR002995]", "Surfeit locus 6 [IPR007019]", "Symplekin/Pta1 [IPR021850]", "Synaptic vesicle protein SV2 [IPR022308]", "Synaptobrevin [IPR001388]", "Synaptogyrin [IPR016579]", "Syndetin [IPR040047]", "Syntaxin [IPR045242]", "Synthesis of cytochrome c oxidase, Sco1/Sco2 [IPR017276]", "T-complex protein 1, alpha subunit [IPR012715]", "T-complex protein 1, beta subunit [IPR012716]", "T-complex protein 1, delta subunit [IPR012717]", "T-complex protein 1, epsilon subunit [IPR012718]", "T-complex protein 1, eta subunit [IPR012720]", "T-complex protein 1, gamma subunit [IPR012719]", "T-complex protein 1, theta subunit [IPR012721]", "T-complex protein 1, zeta subunit [IPR012722]", "TACC family [IPR039915]", "TAF15/EWS/TLS family [IPR034870]", "TAP46-like protein [IPR007304]", "TATA binding associated factor 15 [IPR034875]", "TB2/DP1/HVA22-related protein [IPR004345]", "TCF25/Rqc1 [IPR006994]", "TE2IP/Rap1 [IPR039595]", "TFP11/STIP/Ntr1 [IPR045211]", "TH1 protein [IPR006942]", "THO complex subunit 2 [IPR040007]", "THO complex subunit 6 [IPR042626]", "THO complex, subunit 5 [IPR019163]", "THO complex, subunit THOC1 [IPR021861]", "THRAP3/BCLAF1 family [IPR029199]", "THUMP domain-containing protein 1-like [IPR040183]", "TMEM115/Pdh1/Rbl19 [IPR013861]", "TMEM14 family [IPR005349]", "TMEM192 family [IPR029399]", "TMEM33/Pom33 family [IPR005344]", "TMEM85/ER membrane protein complex subunit 4 [IPR009445]", "TOX high mobility group box family member 4 [IPR037985]", "TPP-binding domain containing protein HACL1-like [IPR045025]", "TPX2 [IPR009675]", "TRAPP I complex, subunit 5 [IPR016696]", "TRAPP III complex, Trs85 [IPR024420]", "TREX component Tex1/THOC3 [IPR040132]", "TatSF1-like [IPR034393]", "Taxilin family [IPR026183]", "Telomere-associated protein Rif1 [IPR028566]", "Testin [IPR027683]", "Testis-expressed protein 10/pre-rRNA-processing protein Ipi1 [IPR037947]", "Tetracycline resistance protein TetA/multidrug resistance protein MdtG [IPR001958]", "Tetrahydrofolate dehydrogenase/cyclohydrolase [IPR000672]", "Tetraspanin, animals [IPR000301]", "Tetraspanin/Peripherin [IPR018499]", "Tetratricopeptide repeat protein 19 [IPR040395]", "Tetratricopeptide repeat protein 21A/21B [IPR040364]", "Tetratricopeptide repeat protein 26 [IPR030511]", "Tetratricopeptide repeat protein 38 [IPR033891]", "Tetratricopeptide repeat protein TTC27/Emw1 [IPR044244]", "ThiF/MoeB/HesA family [IPR045886]", "Thiamine pyrophosphate enzyme [IPR045229]", "Thiolase [IPR002155]", "Thioredoxin domain-containing protein 17-like [IPR045108]", "Thioredoxin-related transmembrane protein 2 [IPR039101]", "Thioredoxin/glutathione reductase selenoprotein [IPR006338]", "Threonine-tRNA ligase, class IIa [IPR002320]", "Thymidine kinase [IPR001267]", "Thymidylate kinase [IPR018094]", "Thymidylate synthase [IPR000398]", "Thymidylate synthase/dCMP hydroxymethylase [IPR045097]", "Thyroid hormone receptor-associated protein 3 [IPR026667]", "Tight junction protein ZO [IPR005417]", "Tight junction protein ZO-1 [IPR005418]", "Tim23-like [IPR045238]", "Tim44-like [IPR039544]", "Tissue alpha-L-fucosidase [IPR028755]", "TmcA/NAT10/Kre33 [IPR032672]", "Tom40 [IPR037930]", "Torsin-1A-interacting protein 1/2 [IPR008662]", "TraB/PrgY/GumN family [IPR002816]", "Trafficking protein particle complex subunit [IPR007233]", "Trans-isoprenyl diphosphate synthases, eukaryotic-type [IPR044844]", "Transaldolase type 1 [IPR004730]", "Transaldolase/Fructose-6-phosphate aldolase [IPR001585]", "Transcription elongation factor SPT5 [IPR039659]", "Transcription elongation factor Spt5, eukaryote [IPR017071]", "Transcription elongation factor Spt6 [IPR017072]", "Transcription elongation factor, IIS-type [IPR035100]", "Transcription elongation factor, TFIIS [IPR006289]", "Transcription elongation regulator 1-like [IPR045148]", "Transcription facto Tfc3-like [IPR044210]", "Transcription factor BTF3 [IPR039370]", "Transcription factor II-I [IPR016659]", "Transcription factor IIIC subunit Tfc1/Sfc1 [IPR040454]", "Transcription factor STAT [IPR001217]", "Transcription factor Tfc4/TFIIIC-102/Sfc4 [IPR039340]", "Transcription initiation factor IIF, alpha subunit [IPR008851]", "Transcription initiation factor TFIID subunit 2 [IPR037813]", "Transcription initiation factor TFIID subunit 5 [IPR037783]", "Transcription initiation factor TFIID subunit 6 [IPR037796]", "Transcription intermediary factor 1-beta [IPR037373]", "Transcription-associated protein 1 [IPR033317]", "Transcriptional regulatory protein Sin3-like [IPR039774]", "Transcriptional regulatory protein Sin3a [IPR037969]", "Transcriptional repressor p66 [IPR040386]", "Transducin beta-like protein 2 [IPR042410]", "Transferrin receptor protein 1 [IPR029513]", "Transgelin-2 [IPR001061]", "Translation elongation factor EF1A, eukaryotic/archaeal [IPR004539]", "Translation elongation factor EFG/EF2 [IPR004540]", "Translation elongation factor EFTs/EF1B [IPR001816]", "Translation elongation factor EFTu/EF1A, bacterial/organelle [IPR004541]", "Translation elongation factor IF5A-like [IPR001884]", "Translation initiation factor 2, alpha subunit [IPR011488]", "Translation initiation factor 2A [IPR011387]", "Translation initiation factor 3 complex subunit L [IPR019382]", "Translation initiation factor IF- 2 [IPR015760]", "Translation initiation factor IF2/IF5 [IPR045196]", "Translation initiation factor aIF-2, bacterial-like [IPR000178]", "Translation machinery-associated protein 16 [IPR021346]", "Translational activator Gcn1 [IPR033173]", "Translationally controlled tumour protein [IPR018105]", "Translin family [IPR002848]", "Translocation associated membrane protein [IPR016447]", "Translocation protein Sec63 [IPR027137]", "Translocator protein [IPR030164]", "Translocon-associated protein (TRAP), alpha subunit [IPR005595]", "Transmembrane emp24 domain-containing protein 5 [IPR015717]", "Transmembrane emp24 domain-containing protein 7 [IPR015718]", "Transmembrane emp24 domain-containing protein [IPR015720]", "Transmembrane protein 109 [IPR039492]", "Transmembrane protein 126 [IPR009801]", "Transmembrane protein 201 [IPR040041]", "Transmembrane protein 205 [IPR042623]", "Transmembrane protein 214 [IPR019308]", "Transmembrane protein 230 [IPR044234]", "Transmembrane protein 230/134 [IPR008590]", "Transmembrane protein 43 family [IPR012430]", "Transmembrane protein 65 [IPR019537]", "Transmembrane protein GPR107/GPR108-like [IPR009637]", "Transport protein particle (TRAPP) component [IPR007194]", "Treacle protein [IPR017859]", "Tricarboxylate/iron carrier [IPR004686]", "Triosephosphate isomerase [IPR000652]", "Triosephosphate isomerase, bacterial/eukaryotic [IPR022896]", "Trm112-like [IPR005651]", "Tropomodulin [IPR004934]", "Tropomodulin-3 [IPR030133]", "Tropomyosin [IPR000533]", "Tryptophan-tRNA ligase [IPR002306]", "Tryptophan-tRNA ligase, bacterial-type [IPR024109]", "TspO/MBR-related protein [IPR004307]", "Tubulin [IPR000217]", "Tubulin binding cofactor A [IPR004226]", "Tubulin polyglutamylase TTLL4 [IPR027748]", "Tubulin--tyrosine ligase-like protein 12 [IPR027749]", "Tubulin-folding cofactor D [IPR033162]", "Tubulin-specific chaperone E [IPR044994]", "Tubulin-tyrosine ligase/Tubulin polyglutamylase [IPR004344]", "Tumour protein D52 [IPR007327]", "Tweety [IPR006990]", "Twinfilin [IPR028458]", "Twinkle-like protein [IPR027032]", "Type 1 protein exporter [IPR039421]", "Type II pantothenate kinase [IPR004567]", "Type II phosphatidylinositol 4-kinase Lsb6/PI4K2 [IPR039756]", "Type-1 angiotensin II receptor-associated protein [IPR009436]", "Tyrosine-protein kinase, insulin-like receptor [IPR016246]", "Tyrosine-tRNA ligase [IPR002307]", "Tyrosine-tRNA ligase, bacterial-type [IPR024088]", "U1 small nuclear ribonucleoprotein C [IPR017340]", "U2 small nuclear ribonucleoprotein A' [IPR044640]", "U2 snRNP auxilliary factor, large subunit, splicing factor [IPR006529]", "U3 small nucleolar RNA-associated protein 10 [IPR040191]", "U3 small nucleolar RNA-associated protein 18 [IPR045161]", "U3 small nucleolar RNA-associated protein 25 [IPR010678]", "U3 small nucleolar RNA-associated protein 6 [IPR013949]", "U3 small nucleolar ribonucleoprotein complex, subunit Mpp10 [IPR012173]", "U3 snoRNP protein/Ribosome production factor 1 [IPR044281]", "U4/U6 small nuclear ribonucleoprotein Prp3 [IPR027104]", "U4/U6 small nuclear ribonucleoprotein Prp31 [IPR027105]", "U6 snRNA-associated Sm-like protein LSm2 [IPR016654]", "U6 snRNA-associated Sm-like protein Lsm1/8 [IPR044642]", "UAA transporter [IPR013657]", "UAP56-interacting factor [IPR009782]", "UBAP2/protein lingerer [IPR022166]", "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110kDa subunit [IPR037919]", "UDP-glucose 6-dehydrogenase, eukaryotic type [IPR028356]", "UDP-glucose/GDP-mannose dehydrogenase [IPR017476]", "UDP-glucose:Glycoprotein Glucosyltransferase [IPR009448]", "UDP-sugar pyrophosphorylase [IPR039741]", "UDPGP family [IPR002618]", "UHRF1/2-like [IPR045134]", "UMP-CMP kinase [IPR006266]", "USP39 [IPR033809]", "UTP--glucose-1-phosphate uridylyltransferase [IPR016267]", "UV excision repair protein Rad23 [IPR004806]", "Ubiquitin binding protein, Hrs/VPS27 [IPR017073]", "Ubiquitin carboxyl-terminal hydrolase 10 [IPR028767]", "Ubiquitin carboxyl-terminal hydrolase 14-like [IPR044635]", "Ubiquitin conjugation factor E4 [IPR045132]", "Ubiquitin domain-containing protein UBFD1 [IPR039120]", "Ubiquitin fusion degradation protein Ufd1-like [IPR004854]", "Ubiquitin thioesterase OTUB1 [IPR030298]", "Ubiquitin thioesterase Otubain [IPR016615]", "Ubiquitin-activating enzyme E1 [IPR018075]", "Ubiquitin-fold modifier 1 [IPR005375]", "Ubiquitin-like modifier Hub1/Ubl5 [IPR039732]", "Ubiquitin-protein ligase E3A [IPR017134]", "Ubiquitin-protein ligase E3B/C [IPR044611]", "Ubiquitin-specific peptidase 24 [IPR033382]", "Ubiquitin/SUMO-activating enzyme E1 [IPR000011]", "Ubiquitinyl hydrolase [IPR016652]", "Ubiquitinyl hydrolase, UCH37 type [IPR017390]", "Uncharacterized protein KIAA2013-like [IPR018795]", "Uracil-DNA glycosylase family 1 [IPR002043]", "Ureohydrolase [IPR006035]", "V-type ATPase, V0 complex, 116kDa subunit family [IPR002490]", "V-type ATP synthase catalytic alpha chain [IPR022878]", "V-type ATP synthase regulatory subunit B/beta [IPR022879]", "V-type ATPase subunit E [IPR002842]", "V0 complex accessory subunit Ac45 [IPR008388]", "VPRBP/DCAF1 family [IPR033270]", "Vacuolar protein sorting protein 26 related [IPR028934]", "Vacuolar protein sorting-associated protein 16 [IPR016534]", "Vacuolar protein sorting-associated protein 29 [IPR028661]", "Vacuolar protein sorting-associated protein 33 [IPR027121]", "Vacuolar protein sorting-associated protein 35 [IPR005378]", "Vacuolar protein sorting-associated protein 4 [IPR031255]", "Vacuolar protein sorting-associated protein 9-like [IPR045046]", "Vacuolar protein sorting-associated protein Ist1 [IPR005061]", "Vacuolar protein sorting-associated protein Vta1-like [IPR044538]", "Vacuolar protein-sorting protein Bro1-like [IPR045251]", "Valine-tRNA ligase [IPR002303]", "Vesicle-associated membrane-protein-associated protein [IPR016763]", "Vesicle-fusing ATPase [IPR039812]", "Vesicle-trafficking protein Sec22 [IPR044565]", "Villin/Gelsolin [IPR007122]", "Vimentin [IPR027699]", "Vinculin [IPR017997]", "Vinculin/alpha-catenin [IPR006077]", "Vitamin K-dependent gamma-carboxylase [IPR007782]", "Voltage-dependent anion-selective channel protein 1 [IPR030270]", "Voltage-dependent anion-selective channel protein 2 [IPR030277]", "Voltage-dependent anion-selective channel protein 3 [IPR030271]", "WD repeat BOP1/Erb1 [IPR028598]", "WD repeat Prp46/PLRG1-like [IPR045241]", "WD repeat WDR12/Ytm1 [IPR028599]", "WD repeat-containing protein 11 [IPR039694]", "WD repeat-containing protein DCAF7-like [IPR045159]", "WD repeat-containing protein WDR18/Ipi3/RID3 [IPR045227]", "WD repeat-containing protein WDR46/Utp7 [IPR040315]", "WD40 repeat-containing protein SMU1 [IPR045184]", "WW domain binding protein 11 [IPR019007]", "WW domain-binding protein 2 [IPR033598]", "WW domain-binding protein 2-like [IPR044852]", "Wings apart-like protein [IPR039874]", "Wolframin [IPR026208]", "Wolframin family [IPR026209]", "XMAP215 family [IPR045110]", "XPG/Rad2 endonuclease [IPR006084]", "YAP-binding/ALF4/Glomulin [IPR013877]", "YEATS [IPR005033]", "YLP motif-containing protein 1 [IPR026314]", "YTH domain containing protein [IPR045168]", "YgfZ/GcvT [IPR045179]", "Yif1 family [IPR005578]", "YjeF N-terminal domain-containing protein NAXE-like [IPR032976]", "YjgF/YER057c/UK114 family [IPR006175]", "ZPR1 family [IPR040141]", "Zinc finger CCCH domain-containing protein A/B [IPR039691]", "Zinc finger CCHC domain-containing protein 3 [IPR042509]", "Zinc finger CCHC-type and RNA-binding motif-containing protein 1 [IPR044598]", "Zinc finger FYVE domain containing protein, SARA/endofin [IPR035438]", "Zinc finger FYVE domain-containing protein, endofin [IPR017165]", "Zinc finger Ran-binding domain-containing protein 2 [IPR017337]", "Zinc finger protein 532-like [IPR045914]", "Zinc finger protein 638 [IPR033096]", "Zinc transporter Msc2-like [IPR045316]", "cAMP-dependent protein kinase catalytic subunit [IPR044109]", "cAMP-dependent protein kinase regulatory subunit [IPR012198]", "dCTP pyrophosphatase 1 [IPR025984]", "dTDP-4-dehydrorhamnose reductase family [IPR005913]", "hnRNP A2/B1 [IPR034489]", "mRNA 3'-end-processing protein Rna14-like [IPR045243]", "mRNA cap guanine-N7 methyltransferase [IPR039753]", "mRNA cap guanine-N7 methyltransferase, eukaryotes [IPR016899]", "mRNA export factor Gle2/RAE1 [IPR037631]", "p53 tumour suppressor family [IPR002117]", "rRNA biogenesis protein Rrp5 [IPR045209]", "tRNA (C5-cytosine) methyltransferase, NCL1 [IPR023270]", "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 [IPR017423]", "tRNA (guanine-N1-)-methyltransferase, eukaryotic [IPR007356]", "tRNA (uracil(54)-C(5))-methyltransferase, eukaryotic type [IPR045850]", "tRNA N6-adenosine threonylcarbamoyltransferase Kae1, archaea and eukaryote [IPR034680]", "tRNA guanosine-2'-O-methyltransferase, TRM11 [IPR016691]", "tRNA methyltransferase 10 homologue C [IPR025812]", "tRNA methyltransferase, Trm1 [IPR002905]", "tRNA modification GTPase MnmE [IPR004520]", "tRNA pseudouridine synthase B family [IPR004802]", "tRNA pseudouridine synthase II, TruB [IPR014780]", "tRNA-specific 2-thiouridylase [IPR004506]", "von Willebrand factor A domain-containing protein 8 [IPR039891]"], "available_proteins": ["AAAS", "AACS", "AAR2", "AARS", "AARS2", "AATF", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABHD12", "ABRAXAS2", "ACAA2", "ACADM", "ACAT1", "ACAT2", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACTL6A", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFG3L2", "AGL", "AGPS", "AGTRAP", "AHCY", "AHCYL1", "AHSA1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK6", "AKAP12", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALKBH5", "AMOT", "AMPD2", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC5", "ANKLE2", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEX1", "API5", "APLP2", "APOL2", "APOOL", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFIP1", "ARFIP2", "ARG2", "ARHGDIA", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6", "ARL6IP1", "ARL6IP5", "ARL8A", "ARMC6", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ASAH1", "ASCC1", "ASNA1", "ASNS", "ASPH", "ATAD2", "ATAD3A", "ATAD3B", "ATG9A", "ATIC", "ATP11C", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN2L", "B3GALT6", "B4GAT1", "BABAM2", "BAIAP2", "BANF1", "BASP1", "BCAP31", "BCAS2", "BCCIP", "BCL2L13", "BCLAF1", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRI3BP", "BRIX1", "BSG", "BTF3", "BUB1B", "BUD31", "BYSL", "C11orf58", "C12orf43", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C2orf49", "CAB39", "CAD", "CALD1", "CALR", "CALU", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CAST", "CBFB", "CBR1", "CBX3", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC137", "CCDC22", "CCDC43", "CCDC47", "CCDC58", "CCDC6", "CCDC8", "CCDC86", "CCDC93", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD47", "CDC123", "CDC37", "CDC42", "CDC73", "CDCA2", "CDH2", "CDIPT", "CDK5RAP3", "CDKAL1", "CDS2", "CDV3", "CEBPZ", "CENPF", "CENPI", "CEP170", "CEP44", "CEP55", "CEPT1", "CERS2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1L", "CHERP", "CHMP2A", "CHMP2B", "CHMP4B", "CHMP5", "CHMP6", "CHMP7", "CHORDC1", "CIAPIN1", "CIP2A", "CISD2", "CKAP2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG2", "COG7", "COIL", "COLGALT1", "COMMD4", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7B", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF2", "CPSF7", "CPT2", "CPVL", "CRNKL1", "CRTAP", "CS", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF3", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTR9", "CTSA", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWF19L1", "CXorf57", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DCAF1", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCXR", "DDA1", "DDAH2", "DDB1", "DDOST", "DDRGK1", "DDX54", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS13", "DHRS7", "DHRS7B", "DHX29", "DIABLO", "DIAPH1", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DKC1", "DLAT", "DLD", "DLGAP5", "DLST", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJC10", "DNAJC13", "DNAJC2", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOCK7", "DOHH", "DPH5", "DPM1", "DPP3", "DPYSL2", "DR1", "DRG1", "DRG2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "DYNLL2", "DYNLT1", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC4", "EEF1A2", "EEF1E1", "EEF1G", "EHD1", "EHD4", "EHMT1", "EI24", "EIF2A", "EIF2B1", "EIF2B2", "EIF2B4", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF5", "EIF5A", "EIF5B", "ELAVL1", "ELMOD2", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EMG1", "ENDOD1", "ENO1", "ENO2", "ENSA", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX1", "EPHX2", "EPPK1", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERG28", "ERGIC1", "ERGIC2", "ERGIC3", "ERH", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ESD", "ESF1", "ESS2", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC5", "EXOC6", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC8", "EXOSC9", "EZR", "F11R", "FAH", "FAM114A2", "FAM120A", "FAM162A", "FAM177A1", "FAM213A", "FAM49B", "FAM8A1", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP2", "FARSA", "FARSB", "FAU", "FBL", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FH", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FRG1", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "FYTTD1", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GALK1", "GALM", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GCAT", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GEMIN4", "GET4", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GHDC", "GHITM", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLB1L2", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GM2A", "GMDS", "GMFB", "GNA13", "GNAI2", "GNAI3", "GNG5", "GNL1", "GNL2", "GNPAT", "GNPDA1", "GNS", "GOLGB1", "GOLIM4", "GOLM1", "GORASP2", "GOT1", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPHN", "GPI", "GPR107", "GPR108", "GPS1", "GPX8", "GRPEL1", "GRSF1", "GSDME", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GTF2F1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS5", "HCFC1", "HDAC1", "HDAC2", "HDHD2", "HDHD5", "HEATR1", "HEBP1", "HEBP2", "HECTD1", "HELZ", "HEXA", "HEXB", "HEXIM1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMBS", "HMCES", "HMGA1", "HMGA2", "HMGB1", "HMGB3", "HMGCR", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPC", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPF1", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA12A", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPB11", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUS1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFIT5", "IFNGR1", "IFT27", "IGBP1", "IGF1R", "IGF2BP2", "IK", "IKBIP", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INCENP", "INTS1", "INTS13", "INTS14", "INTS3", "IPO4", "IPO5", "IQSEC1", "IRS4", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITM2B", "ITPA", "ITPK1", "IVD", "JAGN1", "JPT2", "JUP", "KARS", "KDM1A", "KDM3B", "KDSR", "KHDRBS1", "KHDRBS3", "KIAA0100", "KIAA0319L", "KIAA0368", "KIAA1147", "KIAA2013", "KIF14", "KIF18A", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF5B", "KIFBP", "KIN", "KLC1", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "LAMP1", "LAMTOR1", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LIG3", "LIMA1", "LLGL1", "LMAN1", "LNPEP", "LONP1", "LRPAP1", "LRPPRC", "LRRC41", "LRRC47", "LSM12", "LSM2", "LSM4", "LSM6", "LSM7", "LSM8", "LSS", "LTA4H", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAK16", "MANF", "MAP1B", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARCKS", "MARCKSL1", "MARS", "MAT2A", "MAT2B", "MAU2", "MBD3", "MBOAT7", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MDH1", "MDH2", "MDN1", "ME2", "MECP2", "MED24", "MED4", "METTL16", "MFAP1", "MFF", "MFN1", "MFN2", "MFSD10", "MFSD14B", "MFSD3", "MFSD5", "MFSD8", "MGAT1", "MGEA5", "MGST3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MIPEP", "MKRN2", "MLEC", "MMADHC", "MMS19", "MOB4", "MOGS", "MORF4L1", "MORF4L2", "MOV10", "MPDU1", "MPG", "MPHOSPH10", "MPI", "MPST", "MPV17L2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL47", "MRPL51", "MRPL53", "MRPL9", "MRPS11", "MRPS15", "MRPS17", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSN", "MTA1", "MTA2", "MTAP", "MTBP", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR6", "MTOR", "MTR", "MTX1", "MTX2", "MTX3", "MXRA7", "MYBBP1A", "MYCBP", "MYDGF", "MYEF2", "MYG1", "NAA15", "NAA25", "NAA35", "NAA40", "NAE1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NAT10", "NAXE", "NCAPD2", "NCAPD3", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCLN", "NCSTN", "ND1", "NDC1", "NDRG3", "NDUFA13", "NDUFA4", "NDUFAF1", "NDUFB10", "NDUFB4", "NDUFB5", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV2", "NEDD4L", "NEFM", "NELFB", "NELFCD", "NELFE", "NF1", "NHP2", "NIP7", "NIPBL", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL9", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NOVA2", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NSA2", "NSF", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUB1", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDT1", "NUDT21", "NUDT9", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP37", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUTF2", "NXF1", "OAT", "OCIAD1", "OGDH", "OGT", "OLA1", "OPA1", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "OXCT1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAIP2", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PAPSS2", "PARK7", "PARN", "PAWR", "PBDC1", "PBRM1", "PC", "PCBD1", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6IP", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDS5A", "PDS5B", "PDXDC1", "PEBP1", "PECR", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGP", "PHAX", "PHB", "PHB2", "PHF5A", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PIBF1", "PICALM", "PIGK", "PIGS", "PIGT", "PIK3C2A", "PIK3R4", "PIN4", "PIR", "PITHD1", "PITPNB", "PKM", "PLA2G15", "PLBD2", "PLCG1", "PLEC", "PLIN3", "PLRG1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POLA1", "POLD1", "POLD2", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "PON2", "POP1", "POP7", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIH", "PPIL1", "PPIL4", "PPM1F", "PPM1G", "PPOX", "PPP1CA", "PPP1R12A", "PPP2R1A", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP5C", "PPP6R3", "PPT1", "PPT2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38A", "PRPF38B", "PRPF40A", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PRSS3", "PRTFDC1", "PSAP", "PSAT1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PTBP1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTRH2", "PUDP", "PUF60", "PUM3", "PURA", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "PYM1", "QARS", "QKI", "QPRT", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB23", "RAB2A", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RABGGTA", "RAC1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RAP1GDS1", "RAPGEF2", "RARS", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM17", "RBM22", "RBM26", "RBM39", "RBM45", "RBM5", "RBM8A", "RBPJ", "RCC2", "RCL1", "RDH11", "RDH13", "RDX", "RECQL", "REEP5", "REPS1", "RER1", "RETREG3", "REXO2", "REXO4", "RFC1", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIDA", "RIF1", "RNASEH2A", "RNASEH2B", "RNASET2", "RNF14", "RNF2", "RNF20", "RNF219", "RNF40", "RNMT", "RNPEP", "ROCK1", "RPA1", "RPA2", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP15", "RRP1B", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RTCB", "RTFDC1", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "SAE1", "SAFB", "SAFB2", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SARS", "SARS2", "SART1", "SBDS", "SBNO1", "SCAF1", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCD", "SCFD1", "SCO1", "SCO2", "SCPEP1", "SCRN1", "SDAD1", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SELENBP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETDB1", "SF1", "SF3A1", "SF3A3", "SF3B1", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SH3BGRL", "SH3GL1", "SH3GLB1", "SHMT2", "SHTN1", "SIGMAR1", "SIN3A", "SIRT1", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A21", "SLC25A24", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC2A1", "SLC30A7", "SLC35A4", "SLC35B2", "SLC35F2", "SLC3A2", "SLC7A1", "SLC7A5", "SLC9A3R1", "SLC9A6", "SLFN11", "SLK", "SLTM", "SMARCA4", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMCHD1", "SMPD4", "SMU1", "SMYD3", "SNAPIN", "SND1", "SNRPA1", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SNX27", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SPAG5", "SPAG9", "SPART", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPECC1L", "SPR", "SPTBN1", "SQLE", "SRFBP1", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPRB", "SRRT", "SRSF10", "SRSF11", "SRSF6", "SSB", "SSBP1", "SSR1", "SSRP1", "STAG1", "STAG2", "STARD3", "STAT1", "STAT3", "STIP1", "STMN1", "STOML2", "STRBP", "STT3A", "STT3B", "STUB1", "STX12", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SURF4", "SURF6", "SV2A", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TAB1", "TACC3", "TAF15", "TAF2", "TAF5", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TARS", "TARS2", "TBCA", "TBCD", "TBCE", "TBL2", "TCEA1", "TCERG1", "TCF25", "TCOF1", "TCP1", "TECR", "TERF2IP", "TES", "TEX10", "TFB1M", "TFG", "TFIP11", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "TIGAR", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TJP1", "TK1", "TM9SF2", "TM9SF3", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM115", "TMEM126A", "TMEM14C", "TMEM167A", "TMEM192", "TMEM199", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM230", "TMEM259", "TMEM33", "TMEM43", "TMEM65", "TMEM97", "TMOD3", "TMX2", "TNPO1", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TOR1AIP2", "TOX4", "TP53", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP2", "TPRKB", "TPT1", "TPX2", "TRABD", "TRAM1", "TRAP1", "TRAPPC4", "TRAPPC5", "TRAPPC8", "TRIM28", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMT11", "TRMT112", "TRMT1L", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSNAX", "TSPAN6", "TSPO", "TSPYL1", "TSR1", "TSR3", "TST", "TSTA3", "TTC19", "TTC21B", "TTC26", "TTC27", "TTC37", "TTC38", "TTLL12", "TTLL4", "TTYH3", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC9", "TXNL4A", "TXNRD1", "TXNRD2", "TYMS", "U2AF2", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE3A", "UBE3C", "UBE4A", "UBFD1", "UBL5", "UBR1", "UBR4", "UCHL5", "UFD1", "UFL1", "UFM1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119", "UNG", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRFS1", "UQCRQ", "URB1", "USMG5", "USP10", "USP14", "USP24", "USP39", "USP5", "USP9X", "UTP11", "UTP14A", "UTP18", "UTP3", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VPS16", "VPS25", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4A", "VPS4B", "VPS50", "VTA1", "VWA8", "WAPL", "WARS", "WARS2", "WBP11", "WBP2", "WDR11", "WDR12", "WDR18", "WDR33", "WDR46", "WDR82", "WFS1", "WTAP", "XAB2", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", 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b/interpro_homologous_superfamily/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..94653a965e107a8453f4d3e93f28d42e1a058b99 --- /dev/null +++ b/interpro_homologous_superfamily/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:22eca4532c907faf259d9314b35a47a11ddb88fb36483a83a32b3019e8a2a4ab +size 138794 diff --git a/interpro_homologous_superfamily/df_merge.tsv b/interpro_homologous_superfamily/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..74c29bf95345f5a0d90a988eef41fe3f6329a28a --- /dev/null +++ b/interpro_homologous_superfamily/df_merge.tsv @@ -0,0 +1,10 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Alpha/Beta hydrolase fold [IPR029058] 7 19 3.1264775172379906 0.0017691403110762 7.793689320388349 25.487864077669904 0.3803730368869525 0.1931612116461074 2.8504230618688027 2.5849355029363217 1.9090082785106757 0.2379814650369476 6.043465873941649e-06 0.0042640190855243 2.231896890962452e-07 0.0001954922559516 0.0153483993146073 +Glycoside hydrolase superfamily [IPR017853] 11 17 3.0251999493918227 0.0024846880528024 7.094660194174757 15.565533980582524 0.5992585613623983 0.1928722204186086 2.565315823223627 1.245604487832095 1.9386029676344616 0.2695693578719223 0.1641763697723149 0.1201219647894398 0.0001019966150707 5.230027094671286e-09 7.790890151347905e-10 +Nucleophile aminohydrolases, N-terminal [IPR029055] 8 17 2.9915098565774048 0.0027760157644685 6.097087378640777 17.820388349514563 1.118176330768516 0.343571999079937 2.960138290874742 0.7151426259133536 1.128434210928413 0.3328142150103464 0.0006396322141498 0.0065792573185243 0.0016986126979642 1.4492280010576038e-06 1.4175664763662648e-06 +Mitochondrial carrier domain superfamily [IPR023395] 5 19 2.715462998856286 0.0066183171553393 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 0.0278614928576642 0.1706778675257841 0.005693097574516 0.0002680304953179 0.0093317531476842 +K Homology domain, type 1 superfamily [IPR036612] 14 27 2.447385490223613 0.014389684199803 8.754854368932039 25.199029126213592 0.3274932579192284 0.6117373027860772 4.9138797603502615 1.673377791223898 0.8713427238211133 0.3293224632085303 0.230692179891653 1.0 0.3076603852203092 0.002055769463525 9.178233716894836e-06 +Acyl-CoA N-acyltransferase [IPR016181] 2 8 2.1641217617774933 0.0304550057684469 2.5849514563106797 9.300970873786408 0.3026886570520987 0.4824772135374048 1.9004513382103856 1.21347572256257 0.9257996515560925 0.2786861297784554 0.0167389364845026 0.0087935329278829 0.031373049189738 0.0319451393300601 0.1645088237572309 +Importin-alpha, importin-beta-binding domain superfamily [IPR036975] 3 5 2.148923203572935 0.0316404881232532 1.900485436893204 4.162621359223301 -0.0859723492776628 0.5961263336607893 1.2157141643493203 0.6792778306365289 0.8334835296312452 0.3002751483750439 6.1078318265291925e-06 2.196659839709844e-06 1.6865595784317113e-05 4.77609685109951e-06 7.614857799780336e-05 +Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400] 4 5 2.079564438003141 0.0375655016550349 2.813106796116505 6.104368932038835 1.6405397264547834 0.1100883340733615 1.2852875686886795 0.8042848477475721 1.100790504333474 0.1612592696854457 0.0029333243921292 0.0573151884822011 0.0001778916397324 0.0001405335592956 0.0001575214550341 +Homeobox-like domain superfamily [IPR009057] 2 16 1.973241004471664 0.0484681108085505 4.359223300970874 18.16990291262136 0.2677975125816141 0.5907769000478316 3.590316990986693 2.015779256265804 0.8233080237631125 0.3082468357353871 0.6343459247444913 0.5122277386999536 0.7559683387594784 0.6842210295678024 0.974593453705258 diff --git a/interpro_homologous_superfamily/metrics.json b/interpro_homologous_superfamily/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..5612c581bafbc412fa99afbe23778c52dc9631d5 --- /dev/null +++ b/interpro_homologous_superfamily/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2812, + "annotations_size": 917, + "title": "Average number of proteins per term", + "value": 4.608505997818975 +} \ No newline at end of file diff --git a/interpro_homologous_superfamily/paths.json b/interpro_homologous_superfamily/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..6c0aa18d0965ff34586a17502675f51359f861cf --- /dev/null +++ b/interpro_homologous_superfamily/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_homologous_superfamily/fragment/C428/C428_val_log2fc"} \ No newline at end of file diff --git a/interpro_homologous_superfamily/result.tsv b/interpro_homologous_superfamily/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..1d623ffe10309977bc63666c8f6c559edf3799c5 --- /dev/null +++ b/interpro_homologous_superfamily/result.tsv @@ -0,0 +1,115 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Alpha/Beta hydrolase fold [IPR029058] 0.7714769984339966 3.1264775172379906 0.0017691403110762 0.8028397441889796 0.11027963881803 19 P10619,P07099,Q9HB40,P50897,P42785,Q8NCC3,Q9UMR5 7 +Glycoside hydrolase superfamily [IPR017853] 0.7830245382114234 3.0251999493918227 0.0024846880528024 0.8978480912212502 0.11027963881803 17 P16278,P35573,P06280,Q9BTY2,P10253,P54802,P08236,P06865,P04062,O60502,Q8IW92 11 +Nucleophile aminohydrolases, N-terminal [IPR029055] 0.7768873346400287 2.9915098565774048 0.0027760157644685 0.9218516496049648 0.11027963881803 17 P25788,P28074,P20618,Q99436,P28072,P28070,P49721,P60900 8 +Mitochondrial carrier domain superfamily [IPR023395] 0.7013351530970566 2.715462998856286 0.0066183171553393 0.9977327081066494 0.1163689395666861 19 Q70HW3,O43772,Q9Y619,Q9UBX3,Q9H2D1 5 +K Homology domain, type 1 superfamily [IPR036612] 0.5701976698868831 2.447385490223613 0.014389684199803 0.9999983107053808 0.146614893457993 27 O75179,Q06787,Q8N9N2,Q96PU8,P51116,O00425,Q92945,P61978,O75525,Q96I24,P51114,Q9Y6M1,Q07666,Q96AE4 14 +Acyl-CoA N-acyltransferase [IPR016181] 0.7849802588227259 2.1641217617774933 0.0304550057684469 0.9999999999995184 0.1979304968948571 8 Q86UY6,O60502 2 +Importin-alpha, importin-beta-binding domain superfamily [IPR036975] 0.9176634815703018 2.148923203572935 0.0316404881232532 0.9999999999998432 0.1979304968948571 5 O00505,O00629,P52294 3 +Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400] 0.899893124332025 2.079564438003141 0.0375655016550349 0.9999999999999994 0.2113347547096136 5 Q8WUJ1,O15173,Q9UMX5,O43169 4 +Homeobox-like domain superfamily [IPR009057] 0.6108832659152557 1.973241004471664 0.0484681108085505 1.0 0.2525298727922774 16 Q8NB78,Q96G23 2 +Immunoglobulin-like domain superfamily [IPR036179] 0.6897991519066345 1.9304894193940836 0.0535462249515932 1.0 0.2620543621205956 10 P10321,P55899,P01889,P35613,Q9Y624,P04439 6 +Tetratricopeptide-like helical domain superfamily [IPR011990] 0.4039750649162524 1.8662801510884792 0.0620021803272157 1.0 0.2759999968934797 78 O75153,O75718,O00231,Q9Y6X3,Q9UJX2,P13674,Q99614,Q96BR5,Q6P3X3,Q96DB5,Q9Y262,Q13042,Q8IWR0,O76024,O43765,Q6PGP7,Q9UJX3,Q32P28,Q9UJX4,Q9H7B4,Q9BQ70,Q6DKK2,Q92791,P42345 24 +Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097] 0.7344624744581065 1.844241248191164 0.0651479894821209 1.0 0.2769744467665994 7 Q9UIQ6,P55786,P09960,Q6P179 4 +Peptidase M4/M1, CTD superfamily [IPR027268] 0.7344624744581065 1.844241248191164 0.0651479894821209 1.0 0.2769744467665994 7 Q9UIQ6,P55786,P09960,Q6P179 4 +Haem oxygenase-like, multi-helical [IPR016084] 0.972241992882564 1.841192043332856 0.0655934209443853 1.0 0.2769744467665994 2 P30519 1 +Zinc finger, RanBP2-type superfamily [IPR036443] 0.6842331572472559 1.788583716006373 0.073681882292935 1.0 0.2971495642888281 9 Q01844,P35637,P98175,Q92804 4 +Glycosyl hydrolase, all-beta [IPR013780] 0.7584254588213363 1.7819300287541495 0.0747606429114093 1.0 0.2971495642888281 6 P10253,P06280,Q9BTY2 3 +Porin domain superfamily [IPR023614] 0.9293773072791828 1.7720992315477286 0.0763780864960761 1.0 0.2989436172758122 4 P21796 1 +MFS transporter superfamily [IPR036259] 0.6997441192478558 1.7707011300953197 0.0766104144599955 1.0 0.2989436172758122 8 P53985,Q96ES6,Q8NHS3 3 +Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid [IPR008930] 0.9491103202847012 1.746794836582758 0.0806729325758941 1.0 0.2995759873444418 2 P49356 1 +Immunoglobulin E-set [IPR014756] 0.5774437449361894 1.6895672616617756 0.0911107736467669 1.0 0.3043891408406961 14 A6NIH7,O43924,Q8N3C0,Q13432 4 +Class I glutamine amidotransferase-like [IPR029062] 0.7003614074401202 1.6890271067425906 0.091214235416241 1.0 0.3043891408406961 7 Q92820,Q9Y4C2 2 +MHC classes I/II-like antigen recognition protein [IPR011162] 0.8871082621082568 1.6122517880371663 0.1069071599367319 1.0 0.3345865722251986 4 P55899,P01889,P04439 3 +MHC class I-like antigen recognition-like superfamily [IPR037055] 0.8871082621082568 1.6122517880371663 0.1069071599367319 1.0 0.3345865722251986 4 P55899,P01889,P04439 3 +B30.2/SPRY domain superfamily [IPR043136] 0.6407641220522117 1.5746961365899472 0.1153266000185226 1.0 0.350405170943612 9 O15344,Q14258,P19474,Q1KMD3 4 +Beta-grasp domain superfamily [IPR012675] 0.6685393525181355 1.5422662557543847 0.1230089054026755 1.0 0.365718525142476 7 Q9NTK5 1 +L27 domain superfamily [IPR036892] 0.8615887284167849 1.515047308890242 0.1297604238773468 1.0 0.3741833606777581 4 Q14168,O14936 2 +Galactose-binding-like domain superfamily [IPR008979] 0.5867258845262436 1.5118076846487545 0.1305827939015724 1.0 0.375374363660633 11 P08236,Q8IW92 2 +Tubulin/FtsZ, GTPase domain superfamily [IPR036525] 0.7552547203419978 1.49781201961319 0.1341820970720768 1.0 0.3845155719221702 5 P68371,Q9BVA1,Q9BUF5,P07437 4 +Glutathione S-transferase, C-terminal domain superfamily [IPR036282] 0.5177682442332604 1.441361526114732 0.1494825736810594 1.0 0.4055488759335251 17 P78417,Q9H7Z7,P21266 3 +AF1104-like superfamily [IPR036075] 0.8725978647686944 1.432509497834365 0.1519980619010712 1.0 0.4075501533454235 2 Q9NVE7 1 +RNA-binding domain superfamily [IPR035979] 0.3580115619027976 1.4162241994877731 0.1567098728066769 1.0 0.4103024319612838 122 P52597,O14979,P38159,Q13310,P35637,P23588,P43243,Q9Y6M1,P22626,P31943,P11940,P55795,Q13242,P31483,Q9UHX1,Q92804,O60506,Q4G0J3,P52756,Q71RC2,O43390,Q99729,Q9BWF3,P51991,Q14011,Q14103,Q01844,P98175,P31942,P62995,P98179,Q01085,Q96PK6 33 +Nucleotide-binding alpha-beta plait domain superfamily [IPR012677] 0.3568355026705766 1.405527406894831 0.1598645054181156 1.0 0.411908468208072 121 P52597,O14979,P38159,Q13310,P35637,P23588,P43243,Q9Y6M1,P22626,P31943,P11940,P55795,Q13242,P31483,Q9UHX1,Q92804,O60506,Q4G0J3,P52756,O43390,Q99729,Q9BWF3,P51991,Q14011,Q14103,Q01844,P98175,P31942,P62995,P98179,Q01085,Q96PK6 32 +Profilin superfamily [IPR036140] 0.8558718861209968 1.3636977697953243 0.1726627062654804 1.0 0.4295008998823224 2 P35080 1 +FAD/NAD(P)-binding domain superfamily [IPR036188] 0.4985711510461263 1.362548321497376 0.1730249052859807 1.0 0.4295008998823224 18 Q96CU9,Q9UHG3 2 +Prefoldin [IPR009053] 0.7171276993492666 1.340484459593548 0.1800878933355134 1.0 0.438038721985851 5 P61758,O15212,Q9NQP4 3 +Immunoglobulin-like fold [IPR013783] 0.4280498964486757 1.332660850004146 0.182643126441278 1.0 0.4419096225505328 27 O15344,P10321,P55899,P15260,P01889,P10586,P35613,P08236,Q9Y624,Q06330,P04439 11 +Protein-tyrosine phosphatase-like [IPR029021] 0.6210503803148271 1.320451780394222 0.1866842251941363 1.0 0.4477981531679987 7 O14976,Q9Y217,Q06124 3 +Tubulin/FtsZ, C-terminal [IPR008280] 0.8063443746058448 1.3035067198458916 0.1924018237166755 1.0 0.4477981531679987 4 Q9BVA1,P07437 2 +Tubulin, C-terminal [IPR023123] 0.8063443746058448 1.3035067198458916 0.1924018237166755 1.0 0.4477981531679987 4 Q9BVA1,P07437 2 +Tubulin/FtsZ-like, C-terminal domain [IPR037103] 0.8063443746058448 1.3035067198458916 0.1924018237166755 1.0 0.4477981531679987 4 Q9BVA1,P07437 2 +Papain-like cysteine peptidase superfamily [IPR038765] 0.4448236461391776 1.2975974760511189 0.1944256899183578 1.0 0.4489931324794657 23 Q96FW1,Q8TEY7,Q96RU2,Q96K76,Q9UPU5,P07858 6 +GMP phosphodiesterase, delta subunit superfamily [IPR037036] 0.8934073378491953 1.2831797396824145 0.1994291123728846 1.0 0.4570523214167766 3 A6NIH7 1 +Zinc finger, FYVE/PHD-type [IPR011011] 0.4500181495433165 1.1995552913034382 0.2303120989847626 1.0 0.495765715420252 21 Q03164,O14964,O96028 3 +Concanavalin A-like lectin/glucanase domain superfamily [IPR013320] 0.4815024711979203 1.1710390233840609 0.2415830918141683 1.0 0.4990205487976267 16 O15344,P50851,Q1KMD3,Q12907,P19474,Q14258,P17931 7 +Beta-Galactosidase/glucuronidase domain superfamily [IPR036156] 0.7946619217081998 1.113375847217036 0.2655470437013365 1.0 0.5210610540361637 2 P08236 1 +Neurolysin/Thimet oligopeptidase, N-terminal [IPR024080] 0.7939501779359401 1.1104905285250055 0.266787707280848 1.0 0.5216296963252401 2 Q9BYT8 1 +Beta-hexosaminidase-like, domain 2 [IPR029018] 0.8414288750009927 1.0934160407208822 0.2742111738290422 1.0 0.5279992167740925 3 P54802 1 +Chaperone J-domain superfamily [IPR036869] 0.4616724177955711 1.0786304095823454 0.2807525194662277 1.0 0.5279992167740925 17 O75937,O60884,O14976,Q9UBS4,Q8WXX5,Q99543 6 +EB1, C-terminal domain superfamily [IPR036133] 0.7765124555160293 1.040082592236118 0.2983015304518219 1.0 0.5428052289927329 2 Q15555 1 +Histidine phosphatase superfamily [IPR029033] 0.6445746239436837 1.0400090451102622 0.2983356983776852 1.0 0.5428052289927329 5 P11117 1 +FF domain superfamily [IPR036517] 0.7736654804270442 1.0286445210539383 0.3036467489014369 1.0 0.549199346632382 2 O75400 1 +Metallopeptidase, catalytic domain superfamily [IPR024079] 0.7324533160916089 1.0210348479462252 0.3072379287408062 1.0 0.5513682223871418 4 Q9BYT8,P42892 2 +PABC (PABP) domain [IPR036053] 0.8108697896180743 0.9831251007023052 0.3255458719224726 1.0 0.5717308790197227 3 Q13310 1 +Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily [IPR018162] 0.7601423487544646 0.9745691334738243 0.329774030785475 1.0 0.5727325496785618 2 Q5JTZ9 1 +PIN-like domain superfamily [IPR029060] 0.7010571403217674 0.9026718944275828 0.3667000572488961 1.0 0.6080722468304479 4 Q9UQ84 1 +Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily [IPR036940] 0.6969913132754599 0.8874763096982349 0.3748225152468571 1.0 0.6178170757394488 4 P42356,P42345 2 +Six-bladed beta-propeller, TolB-like [IPR011042] 0.6031347334864663 0.8701362585353366 0.3842259448492204 1.0 0.6292993201995603 5 Q07954,Q15165 2 +Thioredoxin-like superfamily [IPR036249] 0.3491280583283035 0.8694729896386898 0.3845884755216993 1.0 0.6292993201995603 49 Q9H2J4,O95881,P78417,Q9H1E5,Q9H7Z7 5 +Ureohydrolase domain superfamily [IPR023696] 0.7343915827772047 0.7158447215660172 0.474087234540322 1.0 0.7153863845349133 3 Q92769 1 +HSP40/DnaJ peptide-binding [IPR008971] 0.5627270498865 0.7082912137046636 0.4787644322608637 1.0 0.7153884866028374 5 O60884 1 +Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [IPR029068] 0.6911032028469907 0.707902138901403 0.4790060313785629 1.0 0.7153884866028374 2 Q9HC38 1 +ENTH/VHS [IPR008942] 0.4348749195372496 0.6819325903277041 0.4952815765957825 1.0 0.7279749415878383 11 Q92783 1 +Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily [IPR018163] 0.5077985666273123 0.6792807473393582 0.4969599928396802 1.0 0.7279749415878383 6 Q5JTZ9,Q9NYK5 2 +MIT domain superfamily [IPR036181] 0.7026295551325513 0.6107504931106372 0.5413647727215791 1.0 0.7525745803212772 3 Q8N0X7 1 +Neurolysin/Thimet oligopeptidase, domain 2 [IPR024077] 0.7009611961552226 0.6053604860685285 0.5449394998182422 1.0 0.7525745803212772 3 P52888,Q9BYT8 2 +Proteasome activator PA28, C-terminal domain superfamily [IPR036997] 0.6986471175756438 0.5979079432511784 0.549901359461868 1.0 0.7536162778072497 3 Q9UL46 1 +Proteasome activator superfamily [IPR036252] 0.6986471175756438 0.5979079432511784 0.549901359461868 1.0 0.7536162778072497 3 Q9UL46 1 +Proteasome activator PA28, N-terminal domain superfamily [IPR036996] 0.6986471175756438 0.5979079432511784 0.549901359461868 1.0 0.7536162778072497 3 Q9UL46 1 +Six-hairpin glycosidase-like superfamily [IPR012341] 0.6919311681216631 0.5764386754907532 0.5643187091664039 1.0 0.7576577691150694 3 O43813 1 +Protein kinase-like domain superfamily [IPR011009] 0.3092196626619012 0.5341287389302327 0.5932524676091995 1.0 0.7731805155456299 53 Q9HA64,P45985,P31751,O14976,Q02750,P21127,Q709F0,Q96KB5,P42356,O14936,P35790,P42345,Q7L7X3 13 +Zinc finger, RING/FYVE/PHD-type [IPR013083] 0.316124511790327 0.523512577606951 0.6006176006485844 1.0 0.7787643673886608 48 O15344,Q8TEY7,Q5VTR2,Q9H000,O14964,P29375,Q8IWS0,O96028,P19474,Q03164,Q14258 11 +Annexin superfamily [IPR037104] 0.4481152811367704 0.5219084417124175 0.601734080403064 1.0 0.7787643673886608 7 P50995,P04083 2 +PNPase/RNase PH domain superfamily [IPR027408] 0.4571802115115873 0.4718075414562852 0.6370641674939277 1.0 0.7937306103176962 6 Q96B26 1 +Exoribonuclease, PH domain 2 superfamily [IPR036345] 0.4571802115115873 0.4718075414562852 0.6370641674939277 1.0 0.7937306103176962 6 Q96B26 1 +Ankyrin repeat-containing domain superfamily [IPR036770] 0.3586234067772209 0.4533846981733761 0.6502717530026252 1.0 0.7963760913294379 18 Q86XL3,Q9P0K7,O75179,O75832 4 +High mobility group box domain superfamily [IPR036910] 0.3775121293366457 0.3911559626279307 0.6956819569976009 1.0 0.8245260924769914 11 O96028 1 +14-3-3 domain superfamily [IPR036815] 0.4354953670705573 0.3889432256894514 0.6973181452731891 1.0 0.8250848247942122 6 P31946,P61981,P62258,P63104,Q04917 5 +GroES-like superfamily [IPR011032] 0.3855181457494043 0.3743361948175717 0.7081542067451971 1.0 0.8314691518378307 10 Q8N4Q0 1 +Zinc finger, CCCH-type superfamily [IPR036855] 0.398708268879727 0.3497900963465308 0.726496232073762 1.0 0.8451933203789984 8 Q9H000,Q86VM9,Q8IWR0 3 +Nucleotidyltransferase superfamily [IPR043519] 0.4241842278696871 0.3476032127850259 0.7281381931291262 1.0 0.8451933203789984 6 Q9NVV4,P51003 2 +NAP-like superfamily [IPR037231] 0.5374789693136626 0.3456736325653735 0.7295880022243684 1.0 0.8458055601008164 4 Q99733,P55209 2 +ARFGAP/RecO-like zinc finger [IPR037278] 0.6088286344223349 0.3351822953559556 0.7374875766063946 1.0 0.8528071976646455 3 Q8N6H7 1 +ArfGAP domain superfamily [IPR038508] 0.6088286344223349 0.3351822953559556 0.7374875766063946 1.0 0.8528071976646455 3 Q8N6H7 1 +Fibronectin type III superfamily [IPR036116] 0.414277736602073 0.3125984658607055 0.7545857438226329 1.0 0.8649439088566929 6 O15344,P15260 2 +EF-hand domain pair [IPR011992] 0.2836043258207221 0.2021415333610254 0.8398060790781849 1.0 0.9289531658802118 44 Q14257,O43852,Q8NF37,P60660,Q66K14,Q96D71,Q96AY3,Q9H8M7,P80303,Q9H223 10 +S-adenosyl-L-methionine-dependent methyltransferase [IPR029063] 0.2806415305988657 0.1887495998849102 0.8502890751390466 1.0 0.936223141424862 27 P21964,Q9BV86,Q08J23,Q86X55 4 +Cyclin-like superfamily [IPR036915] 0.498932384341627 0.156761866877834 0.8754325270320047 1.0 0.9545441465973228 2 P14635 1 +Diaphanous, GTPase-binding domain superfamily [IPR044933] 0.4807829181494624 0.1274699188195953 0.8985684802423217 1.0 0.9705386294254524 2 Q9NSV4 1 +Formin, FH2 domain superfamily [IPR042201] 0.4807829181494624 0.1274699188195953 0.8985684802423217 1.0 0.9705386294254524 2 Q9NSV4 1 +L-Aspartase-like [IPR008948] 0.4765124555160116 0.1212182236464325 0.9035181901715184 1.0 0.9746317108339242 2 P07954 1 +Methylglyoxal synthase-like domain superfamily [IPR036914] 0.4736654804270333 0.1171841295606635 0.906714143041124 1.0 0.974918116163144 2 P27708 1 +DNA-directed RNA polymerase, insert domain superfamily [IPR036643] 0.4608540925266834 0.1003337346565336 0.920079376227837 1.0 0.985645780374914 2 P19387 1 +RNA polymerase, RBP11-like subunit [IPR036603] 0.4608540925266834 0.1003337346565336 0.920079376227837 1.0 0.985645780374914 2 P19387 1 +Myosin S1 fragment, N-terminal [IPR008989] 0.4855820576717659 0.0949891125708488 0.9243234747263886 1.0 0.9886314615134666 3 P35580,P35579 2 +PurM-like, C-terminal domain superfamily [IPR036676] 0.4827340690637214 0.0913947840774877 0.9271789061085948 1.0 0.9886314615134666 3 O15067,P49903 2 +PurM-like, N-terminal domain superfamily [IPR036921] 0.4827340690637214 0.0913947840774877 0.9271789061085948 1.0 0.9886314615134666 3 O15067,P49903 2 +RmlC-like jelly roll fold [IPR014710] 0.3220823948504575 0.0862449670251691 0.931271685332456 1.0 0.99184220145164 8 O00625,P10644,Q6P4Q7 3 +PDZ superfamily [IPR036034] 0.2857069546809227 0.0779264096009853 0.9378865914604728 1.0 0.9933286518577994 15 Q14168,O14936 2 +PITH domain superfamily [IPR037047] 0.4395017793594304 0.0768058271823557 0.9387780150137636 1.0 0.9933286518577994 2 Q9GZP4 1 +HSP20-like chaperone [IPR008978] 0.3144469227901294 0.0763171470509415 0.9391667842537754 1.0 0.9933286518577994 9 Q9P035,Q9HB71,P04792 3 +Pseudouridine synthase, catalytic domain superfamily [IPR020103] 0.4676213632357175 0.0737726551421019 0.9411912857543454 1.0 0.994191571414426 3 Q96PZ0 1 +Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) [IPR045864] 0.2841895837552564 0.0725665957600174 0.9421510093338454 1.0 0.994191571414426 15 Q9Y285 1 +Cyclic nucleotide-binding-like [IPR018490] 0.3988927325394414 0.0567823016644491 0.9547186124146368 1.0 0.9989678102371112 4 Q6P4Q7 1 +Succinyl-CoA synthetase-like [IPR016102] 0.3888888888888864 0.0450907990835288 0.9640349352324512 1.0 1.0 4 P53597,P53396,Q96I99 3 +PUA domain superfamily [IPR036974] 0.3277580071174382 0.0232540991378435 0.981447585383638 1.0 1.0 2 Q9Y221 1 +Ribosomal protein S7 domain superfamily [IPR036823] 0.3227758007117504 0.0225894229249594 0.9819777809595094 1.0 1.0 2 Q9Y2R9 1 +Pyridoxal phosphate-dependent transferase, small domain [IPR015422] 0.2809192720138594 0.0223100462556975 0.9822006351245608 1.0 1.0 11 P23378,O95470,O15270 3 +PPM-type phosphatase domain superfamily [IPR036457] 0.3645467173177931 0.0214899558567693 0.982854815679406 1.0 1.0 4 O15355,Q15750 2 +Ricin B-like lectins [IPR035992] 0.3963151656411804 0.0201190999195162 0.9839483636962982 1.0 1.0 3 Q86SF2 1 +UBA-like superfamily [IPR009060] 0.2678010414475023 0.0154312867204617 0.987688103201964 1.0 1.0 16 Q9UPU5,Q96GG9,Q96RU2 3 +DNA mismatch repair protein MutS, core domain superfamily [IPR036187] 0.3616945532217912 0.0078224083248476 0.9937586848204608 1.0 1.0 3 P43246,P52701 2 +DNA mismatch repair protein MutS, N-terminal [IPR016151] 0.3616945532217912 0.0078224083248476 0.9937586848204608 1.0 1.0 3 P43246,P52701 2 +MutS, connector domain superfamily [IPR036678] 0.3616945532217912 0.0078224083248476 0.9937586848204608 1.0 1.0 3 P43246,P52701 2 +Dbl homology (DH) domain superfamily [IPR035899] 0.3189747241011074 0.0002623447159112 0.9997906792039672 1.0 1.0 3 O94887,Q14155 2 diff --git a/interpro_homologous_superfamily/selections.json b/interpro_homologous_superfamily/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..032968fc8b86ef7a5c32ff3715bf89bd67f4cc26 --- /dev/null +++ b/interpro_homologous_superfamily/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["14-3-3 domain superfamily [IPR036815]", "2Fe-2S ferredoxin-like superfamily [IPR036010]", "30s ribosomal protein S13, C-terminal [IPR027437]", "4'-phosphopantetheinyl transferase domain superfamily [IPR037143]", "5'-3' exonuclease, C-terminal domain superfamily [IPR036279]", "5-formyltetrahydrofolate cyclo-ligase-like domain superfamily [IPR024185]", "50S ribosomal protein L10, insertion domain superfamily [IPR043164]", "50S ribosomal protein L30e-like [IPR029064]", "6-phosphogluconate dehydrogenase, domain 2 [IPR013328]", "6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily [IPR008927]", "AAR2, C-terminal domain superfamily [IPR038514]", "AAR2, N-terminal domain superfamily [IPR038516]", "ABC transporter type 1, transmembrane domain superfamily [IPR036640]", "ACP-like superfamily [IPR036736]", "ADF-H/Gelsolin-like domain superfamily [IPR029006]", "AF1104-like superfamily [IPR036075]", "AH/BAR domain superfamily [IPR027267]", "AICAR transformylase, duplicated domain superfamily [IPR024051]", "AICAR transformylase, insert domain superfamily [IPR024050]", "AMP-binding enzyme, C-terminal domain superfamily [IPR045851]", "ANL, N-terminal domain [IPR042099]", "ANTH domain superfamily [IPR014712]", "AP-2 complex subunit mu, C-terminal superfamily [IPR036168]", "ARFGAP/RecO-like zinc finger [IPR037278]", "ARID DNA-binding domain superfamily [IPR036431]", "ATP synthase subunit alpha, N-terminal domain-like superfamily [IPR023366]", "ATP synthase, F0 complex, subunit D superfamily, mitochondrial [IPR036228]", "ATP synthase, F1 complex, gamma subunit superfamily [IPR035968]", "ATP synthase, alpha subunit, C-terminal domain superfamily [IPR038376]", "ATP-grasp fold, subdomain 1 [IPR013815]", "ATP:guanido phosphotransferase, N-terminal domain superfamily [IPR036802]", "ATPase, F1/V1 complex, beta/alpha subunit, C-terminal [IPR024034]", "ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily [IPR036121]", "ATPase, V1 complex, subunit H, C-terminal domain superfamily [IPR038497]", "ATPase, nucleotide binding domain [IPR043129]", "Acetylglutamate kinase-like superfamily [IPR036393]", "Aconitase, domain 2 [IPR015932]", "Aconitase, iron-sulfur domain [IPR036008]", "Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 [IPR015931]", "Aconitase/3-isopropylmalate dehydratase, swivel [IPR015928]", "Actin-crosslinking [IPR008999]", "Actin-related protein 2/3 complex subunit 3 superfamily [IPR036753]", "Activator of Hsp90 ATPase, Aha1 [IPR036338]", "Acyl transferase domain superfamily [IPR001227]", "Acyl transferase/acyl hydrolase/lysophospholipase [IPR016035]", "Acyl-CoA N-acyltransferase [IPR016181]", "Acyl-CoA binding protein superfamily [IPR035984]", "Acyl-CoA dehydrogenase-like, C-terminal [IPR036250]", "Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily [IPR009100]", "Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily [IPR037069]", "Acyl-CoA thioesterase, double hotdog domain [IPR042171]", "Adenine nucleotide alpha hydrolase-like domains [IPR023382]", "Adenosylhomocysteinase-like superfamily [IPR042172]", "Adenylate cyclase-associated CAP, C-terminal superfamily [IPR036223]", "Adenylate cyclase-associated CAP, N-terminal domain superfamily [IPR036222]", "Adenylate kinase, active site lid domain superfamily [IPR036193]", "Adenylosuccinate synthetase, domain 1 [IPR042109]", "Adenylosuccinate synthetase, domain 2 [IPR042110]", "Adenylosuccinate synthetase, domain 3 [IPR042111]", "Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily [IPR018162]", "Alba-like domain superfamily [IPR036882]", "Aldehyde dehydrogenase, C-terminal [IPR016163]", "Aldehyde dehydrogenase, N-terminal [IPR016162]", "Aldehyde/histidinol dehydrogenase [IPR016161]", "Aldolase-type TIM barrel [IPR013785]", "Alkaline-phosphatase-like, core domain superfamily [IPR017850]", "Allosteric substrate binding domain superfamily [IPR029009]", "Alpha-D-phosphohexomutase, C-terminal domain superfamily [IPR036900]", "Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III [IPR016055]", "Alpha-catenin/vinculin-like superfamily [IPR036723]", "Alpha-glycerophosphate oxidase, C-terminal domain superfamily [IPR038299]", "Alpha-helical ferredoxin [IPR009051]", "Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily [IPR036784]", "Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily [IPR037151]", "Alpha/Beta hydrolase fold [IPR029058]", "Alpha/beta knot methyltransferases [IPR029028]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 [IPR020751]", "Aminoacyl-tRNA synthetase, class I, anticodon-binding superfamily [IPR008925]", "Aminoacyl-tRNA synthetase, class Ia, anticodon-binding [IPR009080]", "Aminopeptidase N-like , N-terminal domain superfamliy [IPR042097]", "Amyloidogenic glycoprotein, copper-binding domain superfamily [IPR036669]", "Amyloidogenic glycoprotein, heparin-binding domain superfamily [IPR036454]", "Ankyrin repeat-containing domain superfamily [IPR036770]", "Annexin superfamily [IPR037104]", "Anticodon-binding domain superfamily [IPR036621]", "Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain superfamily [IPR036732]", "ApaG domain superfamily [IPR036767]", "ArfGAP domain superfamily [IPR038508]", "Arginyl tRNA synthetase N-terminal domain superfamily [IPR036695]", "Armadillo-like helical [IPR011989]", "Armadillo-type fold [IPR016024]", "Arp2/3 complex subunit 2/4 [IPR034666]", "Arrestin-like, C-terminal [IPR014752]", "Aspartate decarboxylase-like domain superfamily [IPR009010]", "Aspartate/ornithine carbamoyltransferase superfamily [IPR036901]", "Aspartic peptidase domain superfamily [IPR021109]", "Aspartyl/glutamyl-tRNA amidotransferase subunit B-like [IPR003789]", "Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C-terminal, domain 2 [IPR023168]", "At2g17340, three-helix bundle domain [IPR035073]", "B30.2/SPRY domain superfamily [IPR043136]", "BEACH domain superfamily [IPR036372]", "BRCT domain superfamily [IPR036420]", "BRK domain superfamily [IPR037259]", "BRO1 domain superfamily [IPR038499]", "BSD domain superfamily [IPR035925]", "Band 7/SPFH domain superfamily [IPR036013]", "Barrier-to-autointegration factor, BAF superfamily [IPR036617]", "Bcl-2-like superfamily [IPR036834]", "Beta-Galactosidase/glucuronidase domain superfamily [IPR036156]", "Beta-grasp domain superfamily [IPR012675]", "Beta-hexosaminidase-like, domain 2 [IPR029018]", "Beta-lactamase/transpeptidase-like [IPR012338]", "Beta-trefoil domain superfamily [IPR036358]", "BolA-like superfamily [IPR036065]", "Bromo adjacent homology (BAH) domain superfamily [IPR043151]", "Bromodomain-like superfamily [IPR036427]", "C-type lectin fold [IPR016187]", "C-type lectin-like/link domain superfamily [IPR016186]", "C2 domain superfamily [IPR035892]", "CAP Gly-rich domain superfamily [IPR036859]", "CCR4-NOT subunit 1, TTP binding domain superfamily [IPR038535]", "CDC48 domain 2-like superfamily [IPR029067]", "CDP-alcohol phosphatidyltransferase, transmembrane domain [IPR043130]", "CGI121/TPRKB superfamily [IPR036504]", "CH domain superfamily [IPR036872]", "CRAL-TRIO lipid binding domain superfamily [IPR036865]", "CRAL/TRIO, N-terminal domain superfamily [IPR036273]", "CRIB domain superfamily [IPR036936]", "CSTF1, dimerization domain superfamily [IPR038184]", "Cadherin-like superfamily [IPR015919]", "Calcyclin-binding protein, N-terminal [IPR037201]", "Calpain large subunit, domain III superfamily [IPR036213]", "Calreticulin/calnexin, P domain superfamily [IPR009033]", "Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily [IPR036480]", "Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily [IPR036897]", "Carbohydrate-binding-like fold [IPR013784]", "Carbon-nitrogen hydrolase superfamily [IPR036526]", "Carboxypeptidase-like, regulatory domain superfamily [IPR008969]", "Carnitine o-acyltransferase, N-terminal [IPR042572]", "Casein kinase II subunit beta-like [IPR035991]", "Casein kinase II, regulatory subunit, N-terminal [IPR016149]", "Catenin binding domain superfamily [IPR027397]", "Cathepsin C, exclusion domain superfamily [IPR036496]", "Cation efflux transmembrane domain superfamily [IPR027469]", "Cdc37, Hsp90-binding domain superfamily [IPR038189]", "Cell division control protein 73, C-terminal domain superfamily [IPR038103]", "Chaperone J-domain superfamily [IPR036869]", "Chitinase insertion domain superfamily [IPR029070]", "Chloramphenicol acetyltransferase-like domain superfamily [IPR023213]", "Chloride channel, core [IPR014743]", "Choline/Carnitine o-acyltransferase, domain 2 [IPR042231]", "Chromo-like domain superfamily [IPR016197]", "Citrate synthase superfamily [IPR036969]", "Citrate synthase-like, large alpha subdomain [IPR016142]", "Citrate synthase-like, small alpha subdomain [IPR016143]", "Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm [IPR010978]", "Class I glutamine amidotransferase-like [IPR029062]", "Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) [IPR045864]", "Class II aldolase/adducin N-terminal domain superfamily [IPR036409]", "Clathrin adaptor, appendage, Ig-like subdomain superfamily [IPR013041]", "Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain [IPR013037]", "Clathrin heavy chain, N-terminal [IPR016025]", "ClpP/crotonase-like domain superfamily [IPR029045]", "Coatomer, gamma subunit, appendage domain superfamily [IPR037067]", "Coatomer/calthrin adaptor appendage, C-terminal subdomain [IPR009028]", "Cobalamin (vitamin B12)-dependent enzyme, catalytic [IPR016176]", "Cobalamin-binding domain superfamily [IPR036724]", "Concanavalin A-like lectin/glucanase domain superfamily [IPR013320]", "Core-binding factor, beta subunit superfamily [IPR036552]", "Creatinase/Aminopeptidase P/Spt16, N-terminal [IPR029149]", "Creatinase/aminopeptidase-like [IPR036005]", "Cullin homology domain superfamily [IPR036317]", "Cullin repeat-like-containing domain superfamily [IPR016159]", "Cupredoxin [IPR008972]", "Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal [IPR016098]", "Cyclic nucleotide-binding-like [IPR018490]", "Cyclic phosphodiesterase [IPR009097]", "Cyclin-like superfamily [IPR036915]", "Cyclophilin-like domain superfamily [IPR029000]", "Cytidine deaminase-like [IPR016193]", "Cytochrome C oxidase subunit II, transmembrane domain superfamily [IPR036257]", "Cytochrome P450 superfamily [IPR036396]", "Cytochrome b-c1 complex subunit 7 superfamily [IPR036544]", "Cytochrome b-c1 complex subunit 8 superfamily [IPR036642]", "Cytochrome b-c1 complex subunit 9 superfamily [IPR036656]", "Cytochrome b5-like heme/steroid binding domain superfamily [IPR036400]", "Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily [IPR037008]", "Cytochrome c oxidase subunit IV superfamily [IPR036639]", "Cytochrome c oxidase subunit VIIc superfamily [IPR036636]", "Cytochrome c oxidase, subunit VIIa superfamily [IPR036539]", "Cytochrome c oxidase, subunit Va/VI superfamily [IPR036545]", "Cytochrome c oxidase, subunit Vb superfamily [IPR036972]", "Cytochrome c-like domain superfamily [IPR036909]", "Cytochrome c1, transmembrane anchor, C-terminal [IPR021157]", "Cytochrome cd1-nitrite reductase-like, haem d1 domain superfamily [IPR011048]", "DCN1-like, PONY binding domain [IPR042460]", "DHBP synthase RibB-like alpha/beta domain superfamily [IPR017945]", "DHS-like NAD/FAD-binding domain superfamily [IPR029035]", "DNA breaking-rejoining enzyme, catalytic core [IPR011010]", "DNA fragmentation factor 45kDa, C-terminal [IPR027296]", "DNA ligase, ATP-dependent, N-terminal domain superfamily [IPR036599]", "DNA mismatch repair protein MutS, N-terminal [IPR016151]", "DNA mismatch repair protein MutS, core domain superfamily [IPR036187]", "DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal [IPR008921]", "DNA polymerase alpha, zinc finger domain superfamily [IPR038256]", "DNA polymerase family B, thumb domain [IPR042087]", "DNA polymerase, palm domain superfamily [IPR023211]", "DNA repair protein XRCC4-like, C-terminal [IPR014751]", "DNA topoisomerase I, DNA binding, N-terminal domain 1 [IPR013034]", "DNA topoisomerase I, DNA binding, N-terminal domain 2 [IPR013030]", "DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily [IPR036202]", "DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type [IPR014711]", "DNA topoisomerase I, catalytic core, alpha/beta subdomain [IPR014727]", "DNA topoisomerase, type IIA, alpha-helical domain superfamily [IPR013757]", "DNA topoisomerase, type IIA, domain A, alpha-beta [IPR013758]", "DNA topoisomerase, type IIA, subunit B, C-terminal [IPR013759]", "DNA topoisomerase, type IIA-like domain superfamily [IPR013760]", "DNA-binding domain superfamily [IPR016177]", "DNA-directed RNA polymerase, N-terminal domain superfamily [IPR037159]", "DNA-directed RNA polymerase, insert domain superfamily [IPR036643]", "DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily [IPR037033]", "DNA/RNA non-specific endonuclease superfamily [IPR044929]", "DNA/RNA polymerase superfamily [IPR043502]", "DNA/RNA-binding protein KIN17, WH-like domain superfamily [IPR038254]", "DUSP-like superfamily [IPR035927]", "Dbl homology (DH) domain superfamily [IPR035899]", "Death-like domain superfamily [IPR011029]", "Dedicator of cytokinesis, C-terminal, lobe A [IPR043161]", "Dedicator of cytokinesis, C-terminal, lobe C [IPR043162]", "Dedicator of cytokinesis, N-terminal, subdomain 1 [IPR042455]", "Diaphanous, GTPase-binding domain superfamily [IPR044933]", "Dihydrofolate reductase-like domain superfamily [IPR024072]", "Dihydropteroate synthase-like [IPR011005]", "Dimeric alpha-beta barrel [IPR011008]", "Dynein heavy chain AAA lid domain superfamily [IPR042219]", "Dynein heavy chain, AAA1 domain, small subdomain [IPR043157]", "Dynein heavy chain, C-terminal domain, barrel region [IPR043160]", "Dynein heavy chain, domain 2, N-terminal [IPR042222]", "Dynein heavy chain, linker, subdomain 3 [IPR042228]", "Dynein light chain superfamily [IPR037177]", "E2 domain superfamily [IPR036176]", "E3 ubiquitin-protein ligase ELL-like [IPR042065]", "E3-binding domain superfamily [IPR036625]", "EB1, C-terminal domain superfamily [IPR036133]", "EF-G domain III/V-like [IPR035647]", "EF-hand domain pair [IPR011992]", "ENTH/VHS [IPR008942]", "ERO1-like superfamily [IPR037192]", "ERV/ALR sulfhydryl oxidase domain superfamily [IPR036774]", "ESCRT assembly domain [IPR037202]", "ESCRT-II complex, Vps25 subunit, N-terminal winged helix [IPR014041]", "EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2 [IPR042044]", "Elongation factor EF1B gamma, C-terminal domain superfamily [IPR036433]", "Elongation factor Ts, dimerisation domain superfamily [IPR036402]", "Endonuclease/exonuclease/phosphatase superfamily [IPR036691]", "Endoplasmic reticulum resident protein 29, C-terminal domain superfamily [IPR036356]", "Enhancer of mRNA-decapping protein 4, conserved C-terminal domain [IPR044938]", "Enhancer of rudimentary superfamily [IPR035912]", "Enolase-like, C-terminal domain superfamily [IPR036849]", "Enolase-like, N-terminal [IPR029017]", "Enoyl-CoA hydratase, C-terminal [IPR014748]", "Eukaryotic translation initiation factor 3-like domain superfamily [IPR023194]", "Exocyst complex component EXOC6/Sec15, C-terminal, domain 1 [IPR042045]", "Exoribonuclease, PH domain 2 superfamily [IPR036345]", "F-actin capping protein, alpha subunit, domain 1 [IPR042489]", "F-actin-capping protein subunit alpha/beta [IPR037282]", "F-actin-capping protein subunit alpha/beta, domain 2 [IPR042276]", "F-actin-capping protein subunit beta, N-terminal domain [IPR043175]", "F-box-like domain superfamily [IPR036047]", "F1F0 ATP synthase OSCP/delta subunit, N-terminal domain superfamily [IPR026015]", "FAD-binding, type PCMH, subdomain 1 [IPR016167]", "FAD-binding, type PCMH, subdomain 2 [IPR016169]", "FAD-binding, type PCMH-like superfamily [IPR036318]", "FAD-linked oxidase-like, C-terminal [IPR016164]", "FAD/NAD(P)-binding domain superfamily [IPR036188]", "FAD/NAD-linked reductase, dimerisation domain superfamily [IPR016156]", "FCS-type zinc finger superfamily [IPR038603]", "FERM superfamily, second domain [IPR035963]", "FERM/acyl-CoA-binding protein superfamily [IPR014352]", "FF domain superfamily [IPR036517]", "FIP-RBD, C-terminal domain superfamily [IPR037245]", "FKBP12-rapamycin binding domain superfamily [IPR036738]", "FTO, C-terminal domain superfamily [IPR038413]", "Ferredoxin-NADP reductase (FNR), nucleotide-binding domain [IPR039261]", "Ferritin-like superfamily [IPR009078]", "Fibronectin type II domain superfamily [IPR036943]", "Fibronectin type III superfamily [IPR036116]", "Flavoprotein-like superfamily [IPR029039]", "Formin, FH2 domain superfamily [IPR042201]", "Formyl transferase, N-terminal domain superfamily [IPR036477]", "Formyl transferase-like, C-terminal domain superfamily [IPR011034]", "Fumarase/histidase, N-terminal [IPR024083]", "Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily [IPR037099]", "Fumarylacetoacetase, N-terminal domain superfamily [IPR036462]", "Fumarylacetoacetase-like, C-terminal domain superfamily [IPR036663]", "G protein alpha subunit, helical insertion [IPR011025]", "G-protein gamma-like domain superfamily [IPR036284]", "GAD-like domain superfamily [IPR004115]", "GAR domain superfamily [IPR036534]", "GAT domain superfamily [IPR038425]", "GHMP kinase, C-terminal domain superfamily [IPR036554]", "GINS complex, subunit Psf3 superfamily [IPR038437]", "GINS, helical bundle-like domain superfamily [IPR036224]", "GM2-AP, lipid-recognition domain superfamily [IPR036846]", "GMP phosphodiesterase, delta subunit superfamily [IPR037036]", "GOLD domain superfamily [IPR036598]", "GSKIP domain superfamily [IPR023231]", "GTF2I-like repeat superfamily [IPR036647]", "GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1 [IPR027266]", "GTP-binding protein, orthogonal bundle domain superfamily [IPR023179]", "GTP1/OBG domain superfamily [IPR036726]", "GYF-like domain superfamily [IPR035445]", "Galactose mutarotase-like domain superfamily [IPR011013]", "Galactose oxidase/kelch, beta-propeller [IPR011043]", "Galactose-binding-like domain superfamily [IPR008979]", "Gamma-glutamyl cyclotransferase-like superfamily [IPR036568]", "Gamma-tubulin complex component, C-terminal domain superfamily [IPR042241]", "Gelsolin-like domain superfamily [IPR036180]", "Globular protein, non-globular alpha/beta subunit [IPR011070]", "Glutamine synthetase/guanido kinase, catalytic domain [IPR014746]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1 [IPR042558]", "Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2 [IPR042559]", "Glutathione S-transferase, C-terminal domain superfamily [IPR036282]", "Glutathione synthase, C-terminal, eukaryotic [IPR014709]", "Glutathione synthase, N-terminal, eukaryotic [IPR014049]", "Glutathione synthase, alpha-helical [IPR014042]", "Glutathione synthase, substrate-binding domain superfamily [IPR037013]", "Glycine cleavage T-protein/YgfZ, C-terminal [IPR029043]", "Glycoside hydrolase superfamily [IPR017853]", "Glycoside hydrolase-type carbohydrate-binding [IPR014718]", "Glycosyl hydrolase family 63, N-terminal domain superfamily [IPR038518]", "Glycosyl hydrolase, all-beta [IPR013780]", "Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [IPR029068]", "GroEL-like apical domain superfamily [IPR027409]", "GroEL-like equatorial domain superfamily [IPR027413]", "GroES chaperonin superfamily [IPR037124]", "GroES-like superfamily [IPR011032]", "Growth arrest and DNA damage-inducible proteins-interacting protein 1 domain superfamily [IPR043035]", "Growth factor receptor cysteine-rich domain superfamily [IPR009030]", "GrpE nucleotide exchange factor, coiled-coil [IPR013805]", "GrpE nucleotide exchange factor, head [IPR009012]", "H/ACA RNP complex subunit Gar1/Naf1, Cbf5-binding domain [IPR038664]", "HAD superfamily [IPR023214]", "HAD-like superfamily [IPR036412]", "HBS1-like protein, N-terminal domain superfamily [IPR037189]", "HECT, E3 ligase catalytic domain [IPR035983]", "HIT-like superfamily [IPR036265]", "HIV integrase-binding domain superfamily [IPR036218]", "HORMA domain superfamily [IPR036570]", "HR1 repeat superfamily [IPR036274]", "HRDC domain superfamily [IPR044876]", "HRDC-like superfamily [IPR010997]", "HSP20-like chaperone [IPR008978]", "HSP40/DnaJ peptide-binding [IPR008971]", "HSP90, C-terminal domain [IPR037196]", "Haem oxygenase-like, multi-helical [IPR016084]", "Heat shock protein 70kD, C-terminal domain superfamily [IPR029048]", "Heat shock protein 70kD, peptide-binding domain superfamily [IPR029047]", "Heat shock protein DnaJ, cysteine-rich domain superfamily [IPR036410]", "Hemimethylated DNA-binding domain superfamily [IPR036623]", "High mobility group box domain superfamily [IPR036910]", "His-Me finger superfamily [IPR044925]", "Histidine kinase/HSP90-like ATPase superfamily [IPR036890]", "Histidine phosphatase superfamily [IPR029033]", "Histone acetyl transferase 1, N-terminal domain superfamily [IPR037113]", "Histone acetyltransferase HAT1, C-terminal [IPR013523]", "Histone deacetylase domain superfamily [IPR037138]", "Histone-fold [IPR009072]", "Homeobox-like domain superfamily [IPR009057]", "Homocysteine-binding domain superfamily [IPR036589]", "HotDog domain superfamily [IPR029069]", "Hydroxymethylglutaryl-CoA reductase, N-terminal [IPR023282]", "Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily [IPR009023]", "Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily [IPR023074]", "Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily [IPR009029]", "I/LWEQ domain superfamily [IPR035964]", "ISWI, HAND domain superfamily [IPR036306]", "Immunoglobulin E-set [IPR014756]", "Immunoglobulin-like domain superfamily [IPR036179]", "Immunoglobulin-like fold [IPR013783]", "Importin-alpha, importin-beta-binding domain superfamily [IPR036975]", "Initiation factor 2B-like, C-terminal [IPR042529]", "Inorganic polyphosphate/ATP-NAD kinase, N-terminal [IPR017438]", "Inorganic pyrophosphatase superfamily [IPR036649]", "Inosine triphosphate pyrophosphatase-like [IPR029001]", "Integrin beta tail domain superfamily [IPR036349]", "Integrin domain superfamily [IPR032695]", "Interferon regulatory factor 2-binding protein 1/2, C3HC4-type RING finger superfamily [IPR044882]", "Invasin/intimin cell-adhesion fragments [IPR008964]", "Isochorismatase-like superfamily [IPR036380]", "Isopenicillin N synthase-like superfamily [IPR027443]", "Isoprenoid synthase domain superfamily [IPR008949]", "K Homology domain, type 1 superfamily [IPR036612]", "K homology domain superfamily, prokaryotic type [IPR009019]", "K homology domain-like, alpha/beta [IPR015946]", "KA1 domain/Ssp2, C-terminal [IPR028375]", "Kelch-type beta propeller [IPR015915]", "Kinesin motor domain superfamily [IPR036961]", "Kinesin-like protein Kif23, Arf6-interacting domain superfamily [IPR038105]", "Kringle-like fold [IPR013806]", "Ku, C-terminal domain superfamily [IPR036494]", "Ku70, bridge and pillars domain superfamily [IPR027388]", "L-Aspartase-like [IPR008948]", "L21-like superfamily [IPR036164]", "L27 domain superfamily [IPR036892]", "L28p-like [IPR034704]", "LAP1C-like, C-terminal domain superfamily [IPR038599]", "LDL receptor-like superfamily [IPR036055]", "LEM/LEM-like domain superfamily [IPR011015]", "LIS1, N-terminal [IPR037190]", "LSM domain superfamily [IPR010920]", "Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal [IPR015955]", "Lambda repressor-like, DNA-binding domain superfamily [IPR010982]", "Lamin tail domain superfamily [IPR036415]", "Leucine-rich repeat domain superfamily [IPR032675]", "LexA/Signal peptidase-like superfamily [IPR036286]", "Longin-like domain superfamily [IPR011012]", "MAGE homology domain, winged helix WH1 motif [IPR041898]", "MAGE homology domain, winged helix WH2 motif [IPR041899]", "MAN1, winged-helix domain [IPR041885]", "MFS transporter superfamily [IPR036259]", "MHC class I-like antigen recognition-like superfamily [IPR037055]", "MHC classes I/II-like antigen recognition protein [IPR011162]", "MIT domain superfamily [IPR036181]", "MOB kinase activator superfamily [IPR036703]", "MRG, C-terminal domain superfamily [IPR038217]", "MRP-L47 superfamily, mitochondrial [IPR038340]", "Macro domain-like [IPR043472]", "Malic enzyme, N-terminal domain superfamily [IPR037062]", "Malonyl-CoA ACP transacylase, ACP-binding [IPR016036]", "Manganese/iron superoxide dismutase, C-terminal domain superfamily [IPR036314]", "Manganese/iron superoxide dismutase, N-terminal domain superfamily [IPR036324]", "Mannose-6-phosphate receptor binding domain superfamily [IPR009011]", "Membrane associated eicosanoid/glutathione metabolism-like domain superfamily [IPR023352]", "Metal-dependent hydrolase [IPR032466]", "Metal-dependent hydrolase, composite domain superfamily [IPR011059]", "Metallo-dependent phosphatase-like [IPR029052]", "Metalloenzyme, LuxS/M16 peptidase-like [IPR011249]", "Metallopeptidase, catalytic domain superfamily [IPR024079]", "Methionine synthase domain [IPR036594]", "Methionyl-tRNA synthetase, Zn-domain [IPR029038]", "Methylglyoxal synthase-like domain superfamily [IPR036914]", "Methylpurine-DNA glycosylase superfamily [IPR036995]", "Methylthiotransferase, N-terminal domain superfamily [IPR038135]", "Mib/herc2 domain superfamily [IPR037252]", "MitoNEET, CDGSH iron-sulfur domain [IPR042216]", "Mitochondrial carrier domain superfamily [IPR023395]", "Mitochondrial cytochrome c oxidase subunit VIc/VIIs superfamily [IPR037169]", "Mitochondrial glycoprotein superfamily [IPR036561]", "Mitochondrial outer membrane translocase complex, Tom20 domain superfamily [IPR023392]", "MoaB/Mog-like domain superfamily [IPR036425]", "MoeA, C-terminal, domain IV superfamily [IPR036688]", "MoeA, N-terminal and linker domain superfamily [IPR036135]", "Moesin tail domain superfamily [IPR008954]", "Mre11, capping domain [IPR038487]", "Mss4-like superfamily [IPR011057]", "Mss4/translationally controlled tumour-associated TCTP [IPR011323]", "Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily [IPR042179]", "MutS, connector domain superfamily [IPR036678]", "Myosin S1 fragment, N-terminal [IPR008989]", "NAC A/B domain superfamily [IPR038187]", "NAD kinase/diacylglycerol kinase-like domain superfamily [IPR016064]", "NAD(P)-binding domain superfamily [IPR036291]", "NADH-quinone oxidoreductase subunit E, N-terminal [IPR041921]", "NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily [IPR037232]", "NADP-dependent oxidoreductase domain superfamily [IPR036812]", "NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily [IPR023173]", "NAP-like superfamily [IPR037231]", "NET domain superfamily [IPR038336]", "NO signalling/Golgi transport ligand-binding domain superfamily [IPR024096]", "NOB1 zinc finger-like superfamily [IPR036283]", "NSFL1 cofactor p47, SEP domain superfamily [IPR036241]", "NTF2-like domain superfamily [IPR032710]", "NUDIX hydrolase-like domain superfamily [IPR015797]", "NVL2, N-terminal domain superfamily [IPR038100]", "NagB/RpiA transferase-like [IPR037171]", "Neurolysin/Thimet oligopeptidase, N-terminal [IPR024080]", "Neurolysin/Thimet oligopeptidase, domain 2 [IPR024077]", "Nicotinate phosphoribosyltransferase-like, C-terminal [IPR036068]", "Nitrogen regulatory PII-like, alpha/beta [IPR011322]", "Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal [IPR015867]", "Nitrous oxide reductase, N-terminal [IPR011045]", "Nop domain superfamily [IPR036070]", "Nop, C-terminal domain [IPR042239]", "Nucleic acid-binding, OB-fold [IPR012340]", "Nucleophile aminohydrolases, N-terminal [IPR029055]", "Nucleoplasmin core domain superfamily [IPR036824]", "Nucleoporin, Nup155-like, C-terminal, subdomain 1 [IPR042533]", "Nucleoporin, Nup155-like, C-terminal, subdomain 2 [IPR042537]", "Nucleoporin, Nup155-like, C-terminal, subdomain 3 [IPR042538]", "Nucleoside diphosphate kinase-like domain superfamily [IPR036850]", "Nucleoside phosphorylase superfamily [IPR035994]", "Nucleotide-binding alpha-beta plait domain superfamily [IPR012677]", "Nucleotide-diphospho-sugar transferases [IPR029044]", "Nucleotidyltransferase superfamily [IPR043519]", "Nucleotidyltransferase, class I-like, C-terminal [IPR011068]", "Nuf2, N-terminal domain superfamily [IPR038275]", "NusG, N-terminal domain superfamily [IPR036735]", "Oxygen-dependent coproporphyrinogen III oxidase superfamily [IPR036406]", "Oxysterol-binding protein superfamily [IPR037239]", "P-loop containing nucleoside triphosphate hydrolase [IPR027417]", "P-type ATPase, A domain superfamily [IPR008250]", "P-type ATPase, cytoplasmic domain N [IPR023299]", "P-type ATPase, transmembrane domain superfamily [IPR023298]", "P-type trefoil domain superfamily [IPR044913]", "PABC (PABP) domain [IPR036053]", "PADR1 domain superfamily [IPR038650]", "PBDC1-like domain superfamily [IPR023139]", "PCGF Ub-like fold discriminator superfamily [IPR038227]", "PD-(D/E)XK endonuclease-like domain superfamily [IPR011604]", "PDCD5-like superfamily [IPR036883]", "PDZ superfamily [IPR036034]", "PEBP-like superfamily [IPR036610]", "PFU domain superfamily [IPR038122]", "PH-like domain superfamily [IPR011993]", "PHR domain superfamily [IPR038648]", "PIN-like domain superfamily [IPR029060]", "PITH domain superfamily [IPR037047]", "PKD domain superfamily [IPR035986]", "PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily [IPR017946]", "PNPase/RNase PH domain superfamily [IPR027408]", "POLO box domain superfamily [IPR036947]", "PPM-type phosphatase domain superfamily [IPR036457]", "PRP4-like superfamily [IPR036285]", "PTPA superfamily [IPR037218]", "PUA domain superfamily [IPR036974]", "PUA-like superfamily [IPR015947]", "PWI domain superfamily [IPR036483]", "PX domain superfamily [IPR036871]", "Paired amphipathic helix superfamily [IPR036600]", "Pancreatic trypsin inhibitor Kunitz domain superfamily [IPR036880]", "PapD-like superfamily [IPR008962]", "Papain-like cysteine peptidase superfamily [IPR038765]", "Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily [IPR036959]", "Peptidase C65, otubain, subdomain 2 [IPR042467]", "Peptidase C65, otubain, subdomain 1 [IPR042468]", "Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily [IPR038502]", "Peptidase M13, domain 2 [IPR042089]", "Peptidase M4/M1, CTD superfamily [IPR027268]", "Peptidase M41-like [IPR037219]", "Peptidase M60, enhancin-like domain 3 [IPR042279]", "Peptidase S1, PA clan [IPR009003]", "Peptidase S1, PA clan, chymotrypsin-like fold [IPR043504]", "Peptidase S59, nucleoporin superfamily [IPR036903]", "Peptidase S8/S53 domain superfamily [IPR036852]", "Peptidyl-tRNA hydrolase II domain superfamily [IPR023476]", "Pex19, C-terminal domain superfamily [IPR038322]", "Phenylalanyl-tRNA synthetase-like, B3/B4 [IPR020825]", "Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily [IPR036940]", "Phosphoenolpyruvate carboxykinase, C-terminal [IPR013035]", "Phosphoenolpyruvate carboxykinase, N-terminal [IPR008210]", "Phosphofructokinase superfamily [IPR035966]", "Phosphoglucose isomerase, C-terminal [IPR023096]", "Phosphoglycerate kinase superfamily [IPR036043]", "Phosphoglycerate kinase, N-terminal [IPR015824]", "Phosphoglycolate phosphatase-like, domain 2 [IPR023198]", "Phosphoinositide 3-kinase, accessory (PIK) domain superfamily [IPR042236]", "Phospholipase B-like, domain 1 [IPR043040]", "Phospholipase B-like, domain 2 [IPR043041]", "Phospholipase B-like, domain 3 [IPR043042]", "Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily [IPR036604]", "Phosphoribosylglycinamide synthetase, C-domain superfamily [IPR037123]", "Phosphoribosyltransferase-like [IPR029057]", "Phosphorylated adapter RNA export protein, RNA-binding domain superfamily [IPR038092]", "Phosphotyrosine protein phosphatase I superfamily [IPR036196]", "Phosphotyrosyl phosphatase activator, C-terminal lid domain [IPR043170]", "Plakin repeat superfamily [IPR035915]", "Poly(ADP-ribose) polymerase, regulatory domain superfamily [IPR036616]", "Polyketide synthase, dehydratase domain superfamily [IPR042104]", "Polymerase/histidinol phosphatase-like [IPR016195]", "Polyribonucleotide nucleotidyltransferase, RNA-binding domain superfamily [IPR036456]", "Porin domain superfamily [IPR023614]", "Porphobilinogen deaminase, C-terminal domain superfamily [IPR036803]", "Pre-ATP-grasp domain superfamily [IPR016185]", "Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily [IPR042516]", "Prefoldin [IPR009053]", "Profilin superfamily [IPR036140]", "Prolyl-tRNA synthetase, class II [IPR017449]", "Proteasomal ubiquitin receptor Rpn13/ADRM1, Pru domain superfamily [IPR038633]", "Proteasome activator PA28, C-terminal domain superfamily [IPR036997]", "Proteasome activator PA28, N-terminal domain superfamily [IPR036996]", "Proteasome activator superfamily [IPR036252]", "Protein kinase-like domain superfamily [IPR011009]", "Protein-tyrosine phosphatase-like [IPR029021]", "Prp8 RNase domain IV, fingers region [IPR043173]", "Prp8 RNase domain IV, palm region [IPR043172]", "Pseudouridine synthase, TruD, catalytic domain [IPR042214]", "Pseudouridine synthase, catalytic domain superfamily [IPR020103]", "Pterin 4 alpha carbinolamine dehydratase superfamily [IPR036428]", "PurM-like, C-terminal domain superfamily [IPR036676]", "PurM-like, N-terminal domain superfamily [IPR036921]", "Putative DNA-binding domain superfamily [IPR009061]", "Pyridoxal phosphate-dependent transferase [IPR015424]", "Pyridoxal phosphate-dependent transferase, major domain [IPR015421]", "Pyridoxal phosphate-dependent transferase, small domain [IPR015422]", "Pyruvate kinase, C-terminal domain superfamily [IPR036918]", "Pyruvate kinase, insert domain superfamily [IPR015806]", "Pyruvate kinase-like domain superfamily [IPR040442]", "Pyruvate kinase-like, insert domain superfamily [IPR011037]", "Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily [IPR015813]", "Quinolinate phosphoribosyl transferase, N-terminal domain superfamily [IPR037128]", "Quinoprotein alcohol dehydrogenase-like superfamily [IPR011047]", "Quinoprotein amine dehydrogenase, beta chain-like [IPR011044]", "R3H domain superfamily [IPR036867]", "RAP domain superfamily [IPR036744]", "RBP-J/Cbf11, DNA binding domain superfamily [IPR037095]", "RGS domain superfamily [IPR036305]", "RNA 3'-terminal phosphate cyclase domain superfamily [IPR037136]", "RNA 3'-terminal phosphate cyclase, insert domain superfamily [IPR036553]", "RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta [IPR013792]", "RNA polymerase Rpb1, clamp domain superfamily [IPR044893]", "RNA polymerase Rpb1, domain 3 superfamily [IPR042102]", "RNA polymerase Rpb1, domain 7 superfamily [IPR038593]", "RNA polymerase Rpb1, funnel domain superfamily [IPR038120]", "RNA polymerase Rpb2, OB-fold [IPR014724]", "RNA polymerase Rpb2, domain 2 superfamily [IPR037034]", "RNA polymerase Rpb5, N-terminal domain superfamily [IPR036710]", "RNA polymerase Rpb7-like, N-terminal domain superfamily [IPR036898]", "RNA polymerase, RBP11-like subunit [IPR036603]", "RNA-binding S4 domain superfamily [IPR036986]", "RNA-binding domain superfamily [IPR035979]", "RPB5-like RNA polymerase subunit superfamily [IPR035913]", "RPN13, DEUBAD domain superfamily [IPR038108]", "Rab geranylgeranyltransferase, alpha subunit, insert-domain superfamily [IPR036254]", "Rab-GTPase-TBC domain superfamily [IPR035969]", "Radical SAM, alpha/beta horseshoe [IPR023404]", "Ran-GTPase activating protein 1, C-terminal domain superfamily [IPR036720]", "Ras guanine nucleotide exchange factor domain superfamily [IPR023578]", "Ras guanine-nucleotide exchange factor, catalytic domain superfamily [IPR036964]", "Receptor L-domain superfamily [IPR036941]", "Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II [IPR009091]", "Regulatory factor, effector binding domain superfamily [IPR011256]", "Restriction endonuclease type II-like [IPR011335]", "Rho GDP-dissociation inhibitor domain superfamily [IPR024792]", "Rho GTPase activation protein [IPR008936]", "Rhodanese-like domain superfamily [IPR036873]", "Rhomboid-like superfamily [IPR035952]", "Riboflavin synthase-like beta-barrel [IPR017938]", "Ribokinase-like [IPR029056]", "Ribonuclease H superfamily [IPR036397]", "Ribonuclease H-like superfamily [IPR012337]", "Ribonuclease H1, N-terminal domain superfamily [IPR037056]", "Ribonuclease HII, helix-loop-helix cap domain superfamily [IPR023160]", "Ribonuclease III, endonuclease domain superfamily [IPR036389]", "Ribonuclease T2-like superfamily [IPR036430]", "Ribonuclease Z/Hydroxyacylglutathione hydrolase-like [IPR036866]", "Ribonucleotide reductase R1 subunit, N-terminal [IPR008926]", "Ribonucleotide reductase-like [IPR012348]", "Ribosomal L15/L27a, N-terminal [IPR027386]", "Ribosomal L18e/L15P superfamily [IPR036227]", "Ribosomal RNA-processing protein 8, N-terminal domain [IPR042036]", "Ribosomal protein L1, 3-layer alpha/beta-sandwich [IPR016095]", "Ribosomal protein L1-like [IPR023674]", "Ribosomal protein L10-like domain superfamily [IPR043141]", "Ribosomal protein L10e/L16 superfamily [IPR036920]", "Ribosomal protein L11, C-terminal domain superfamily [IPR036769]", "Ribosomal protein L11/L12, N-terminal domain superfamily [IPR036796]", "Ribosomal protein L13 superfamily [IPR036899]", "Ribosomal protein L14 superfamily [IPR036853]", "Ribosomal protein L15e core domain superfamily [IPR024794]", "Ribosomal protein L17 superfamily [IPR036373]", "Ribosomal protein L19 superfamily [IPR038657]", "Ribosomal protein L19/L19e superfamily [IPR035970]", "Ribosomal protein L19/L19e, domain 1 [IPR015972]", "Ribosomal protein L2, domain 2 [IPR014722]", "Ribosomal protein L2, domain 3 [IPR014726]", "Ribosomal protein L20, C-terminal [IPR035566]", "Ribosomal protein L21 superfamily [IPR036948]", "Ribosomal protein L22/L17 superfamily [IPR036394]", "Ribosomal protein L22e superfamily [IPR038526]", "Ribosomal protein L23/L15e core domain superfamily [IPR012678]", "Ribosomal protein L24e/L24 superfamily [IPR038630]", "Ribosomal protein L25/Gln-tRNA synthetase, N-terminal [IPR020056]", "Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily [IPR011035]", "Ribosomal protein L27e superfamily [IPR038655]", "Ribosomal protein L28/L24 superfamily [IPR037147]", "Ribosomal protein L29/L35 superfamily [IPR036049]", "Ribosomal protein L3, domain 3, archaeal type superfamily [IPR044892]", "Ribosomal protein L30, ferredoxin-like fold domain superfamily [IPR036919]", "Ribosomal protein L31e domain superfamily [IPR023621]", "Ribosomal protein L32e superfamily [IPR036351]", "Ribosomal protein L35A superfamily [IPR038661]", "Ribosomal protein L36e domain superfamily [IPR038097]", "Ribosomal protein L37ae/L37e [IPR011331]", "Ribosomal protein L38e superfamily [IPR038464]", "Ribosomal protein L4 domain superfamily [IPR023574]", "Ribosomal protein L5 domain superfamily [IPR022803]", "Ribosomal protein L6, alpha-beta domain superfamily [IPR036789]", "Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like [IPR014719]", "Ribosomal protein L7/L12, oligomerisation domain superfamily [IPR036235]", "Ribosomal protein L9, N-terminal domain superfamily [IPR036935]", "Ribosomal protein L9/RNase H1, N-terminal [IPR009027]", "Ribosomal protein P1/P2, N-terminal domain [IPR038716]", "Ribosomal protein S10 domain superfamily [IPR036838]", "Ribosomal protein S11 superfamily [IPR036967]", "Ribosomal protein S13-like, H2TH [IPR010979]", "Ribosomal protein S17e-like superfamily [IPR036401]", "Ribosomal protein S19/S15, superfamily [IPR023575]", "Ribosomal protein S2, flavodoxin-like domain superfamily [IPR023591]", "Ribosomal protein S26e superfamily [IPR038551]", "Ribosomal protein S3, C-terminal domain superfamily [IPR036419]", "Ribosomal protein S4e, central domain superfamily [IPR038237]", "Ribosomal protein S5 domain 2-type fold [IPR020568]", "Ribosomal protein S5 domain 2-type fold, subgroup [IPR014721]", "Ribosomal protein S7 domain superfamily [IPR036823]", "Ribosomal protein S8 superfamily [IPR035987]", "Ribosomal protein S8e subdomain, eukaryotes [IPR042563]", "Ribosome maturation protein SBDS, N-terminal domain superfamily [IPR036786]", "Ribosome maturation protein Sdo1/SBDS, central domain superfamily [IPR037188]", "Ribosome-associated complex head domain superfamily [IPR042569]", "Ribulose-phosphate binding barrel [IPR011060]", "Ricin B-like lectins [IPR035992]", "RmlC-like cupin domain superfamily [IPR011051]", "RmlC-like jelly roll fold [IPR014710]", "Rossmann-like alpha/beta/alpha sandwich fold [IPR014729]", "Rpb4/RPC9 superfamily [IPR038324]", "Rudiment single hybrid motif [IPR011054]", "RutC-like superfamily [IPR035959]", "RuvA domain 2-like [IPR010994]", "RuvBL1/2, DNA/RNA binding domain [IPR042487]", "S-adenosyl-L-methionine-dependent methyltransferase [IPR029063]", "S-adenosylmethionine synthetase superfamily [IPR022636]", "S15/NS1, RNA-binding [IPR009068]", "SAP domain superfamily [IPR036361]", "SCP2 sterol-binding domain superfamily [IPR036527]", "SGNH hydrolase superfamily [IPR036514]", "SH2 domain superfamily [IPR036860]", "SH3-like domain superfamily [IPR036028]", "SKP1-like, dimerisation domain superfamily [IPR036296]", "SKP1/BTB/POZ domain superfamily [IPR011333]", "SLED domain superfamily [IPR038348]", "SMAD/FHA domain superfamily [IPR008984]", "SMCs flexible hinge superfamily [IPR036277]", "SNARE [IPR010989]", "SNF2-like, N-terminal domain superfamily [IPR038718]", "SNase-like, OB-fold superfamily [IPR035437]", "SOS response associated peptidase-like [IPR036590]", "SPOC-like, C-terminal domain superfamily [IPR016194]", "SRA-YDG superfamily [IPR036987]", "SRCR-like domain superfamily [IPR036772]", "SRP/SRP receptor, N-terminal [IPR036225]", "SRP68, N-terminal domain superfamily [IPR038253]", "SSRP1 domain superfamily [IPR038167]", "START-like domain superfamily [IPR023393]", "STAT transcription factor, DNA-binding, N-terminal [IPR012345]", "STAT transcription factor, N-terminal domain superfamily [IPR036535]", "STAT transcription factor, coiled coil [IPR015988]", "STAT1, C-terminal domain superfamily [IPR038295]", "SUI1 domain superfamily [IPR036877]", "SWAP/Surp superfamily [IPR035967]", "SWIB/MDM2 domain superfamily [IPR036885]", "Saposin-like [IPR011001]", "Scavenger mRNA decapping enzyme, N-terminal [IPR011145]", "Schlafen, AlbA_2 domain superfamily [IPR038461]", "ScpA-like, C-terminal [IPR023093]", "Sec1-like superfamily [IPR036045]", "Sec1-like, domain 1 [IPR043154]", "Sec1-like, domain 2 [IPR027482]", "Sec1-like, domain 3a [IPR043127]", "Sec23/Sec24 helical domain superfamily [IPR036175]", "Sec7 domain superfamily [IPR035999]", "Sec7, C-terminal domain superfamily [IPR023394]", "SecY domain superfamily [IPR023201]", "Secretoglobin superfamily [IPR035960]", "Serine carboxypeptidase S28, SKS domain [IPR042269]", "Serine-tRNA synthetase, type1, N-terminal domain superfamily [IPR042103]", "Serpin superfamily [IPR036186]", "Serpin superfamily, domain 1 [IPR042178]", "Serpin superfamily, domain 2 [IPR042185]", "Set2 Rpb1 interacting domain superfamily [IPR038190]", "Signal recognition particle SRP54, N-terminal domain superfamily [IPR042101]", "Signal recognition particle, SRP54 subunit, M-domain superfamily [IPR036891]", "Signal recognition particle, SRP9/SRP14 subunit [IPR009018]", "Sin3 associated polypeptide p18 superfamily [IPR042534]", "Single hybrid motif [IPR011053]", "Sirtuin, catalytic core small domain superfamily [IPR026591]", "Six-bladed beta-propeller, TolB-like [IPR011042]", "Six-hairpin glycosidase superfamily [IPR008928]", "Six-hairpin glycosidase-like superfamily [IPR012341]", "Smac/DIABLO-like superfamily [IPR009062]", "Smaug, PHAT domain superfamily [IPR037093]", "Sodium/potassium-transporting ATPase subunit beta superfamily [IPR038702]", "Sodium:dicarboxylate symporter superfamily [IPR036458]", "Spermidine synthase, tetramerisation domain superfamily [IPR037163]", "Spt6, Death-like domain [IPR042066]", "Stathmin superfamily [IPR036002]", "Sterile alpha motif/pointed domain superfamily [IPR013761]", "Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily [IPR027477]", "Succinyl-CoA synthetase-like [IPR016102]", "Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain superfamily [IPR042568]", "TAP42/TAP46-like superfamily [IPR038511]", "TBP domain superfamily [IPR012295]", "TCP-1-like chaperonin intermediate domain superfamily [IPR027410]", "TEL2, C-terminal domain superfamily [IPR038528]", "TFIID subunit TAF5, NTD2 domain superfamily [IPR037264]", "TFIIIC, subcomplex tauA subunit Sfc1, triple barrel domain superfamily [IPR042536]", "TFIIS/LEDGF domain superfamily [IPR035441]", "TGS-like [IPR012676]", "TGS-like domain superfamily [IPR023192]", "TMEM14 superfamily [IPR044890]", "TRAF-like [IPR008974]", "TRF2-interacting telomeric protein/Rap1, C-terminal domain superfamily [IPR038104]", "TROVE domain superfamily [IPR037214]", "Talin, central domain superfamily [IPR036476]", "Tautomerase/MIF superfamily [IPR014347]", "Tctex-1-like superfamily [IPR038586]", "Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid [IPR008930]", "Tetrapyrrole methylase superfamily [IPR035996]", "Tetrapyrrole methylase, subdomain 1 [IPR014777]", "Tetrapyrrole methylase, subdomain 2 [IPR014776]", "Tetraspanin, EC2 domain superfamily [IPR008952]", "Tetratricopeptide-like helical domain superfamily [IPR011990]", "Tex-like domain superfamily [IPR023323]", "Tex-like protein, HTH domain superfamily [IPR023319]", "Thiamin diphosphate-binding fold [IPR029061]", "Thiolase-like [IPR016039]", "Thioredoxin-like superfamily [IPR036249]", "Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily [IPR018163]", "Thymidylate synthase/dCMP hydroxymethylase superfamily [IPR036926]", "Tma16 superfamily [IPR038356]", "Transcription Factor IIF, Rap30/Rap74, interaction [IPR011039]", "Transcription elongation factor S-II, central domain superfamily [IPR036575]", "Transferrin receptor-like, dimerisation domain superfamily [IPR036757]", "Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II [IPR009014]", "Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal [IPR009001]", "Translation elongation factor EF1B/ribosomal protein S6 [IPR014717]", "Translation elongation factor eEF-1beta-like superfamily [IPR036219]", "Translation initiation factor 2, alpha subunit, C-terminal [IPR024055]", "Translation initiation factor 2, alpha subunit, middle domain superfamily [IPR024054]", "Translation initiation factor 3, subunit 12, N-terminal, eukaryotic [IPR016020]", "Translation initiation factor IF-2, domain 3 superfamily [IPR036925]", "Translation initiation factor IF2/IF5, N-terminal [IPR016189]", "Translation initiation factor IF2/IF5, zinc-binding [IPR016190]", "Translation initiation factor eIF-2B subunit alpha, N-terminal [IPR042528]", "Translation protein SH3-like domain superfamily [IPR008991]", "Translation protein, beta-barrel domain superfamily [IPR009000]", "Translin superfamily [IPR036081]", "Translin, C-terminal [IPR016069]", "Translin, N-terminal [IPR016068]", "Trimeric LpxA-like superfamily [IPR011004]", "Triosephosphate isomerase superfamily [IPR035990]", "TspO/MBR-related superfamily [IPR038330]", "Tubulin binding cofactor A superfamily [IPR036126]", "Tubulin, C-terminal [IPR023123]", "Tubulin/FtsZ, C-terminal [IPR008280]", "Tubulin/FtsZ, GTPase domain superfamily [IPR036525]", "Tubulin/FtsZ-like, C-terminal domain [IPR037103]", "UBA-like superfamily [IPR009060]", "UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily [IPR036220]", "Ubiquitin activating enzyme, alpha domain superfamily [IPR023318]", "Ubiquitin-activating enzyme E1, C-terminal domain superfamily [IPR038252]", "Ubiquitin-activating enzyme E1, FCCH domain superfamily [IPR042302]", "Ubiquitin-activating enzyme E1, SCCH domain [IPR042063]", "Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 [IPR042449]", "Ubiquitin-activating enzyme [IPR035985]", "Ubiquitin-conjugating enzyme/RWD-like [IPR016135]", "Ubiquitin-like domain superfamily [IPR029071]", "Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain superfamily [IPR042556]", "Ufd1-like, Nn domain [IPR042299]", "Uracil-DNA glycosylase-like domain superfamily [IPR036895]", "Ureohydrolase domain superfamily [IPR023696]", "V-type ATP synthase c/d subunit, domain 3 superfamily [IPR044911]", "V-type ATP synthase subunit c/d subunit superfamily [IPR036079]", "V-type ATPase subunit C/d [IPR035067]", "V-type ATPase subunit E, C-terminal domain superfamily [IPR038495]", "VASP tetramerisation domain superfamily [IPR038023]", "VPS9 domain superfamily [IPR037191]", "Vacuolar ATP synthase subunit C superfamily [IPR036132]", "Vacuolar protein sorting-associated protein 33, domain 3b [IPR043155]", "Vacuolar protein sorting-associated protein 35, C-terminal [IPR042491]", "Vacuolar protein sorting-associated protein IST1-like [IPR042277]", "Valyl-tRNA synthetase, tRNA-binding arm superfamily [IPR037118]", "Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain [IPR009008]", "Vanillyl-alcohol oxidase, C-terminal subdomain 2 [IPR016171]", "Vitamin B12-dependent methionine synthase, activation domain superfamily [IPR037010]", "Vps16, C-terminal domain superfamily [IPR038132]", "Vta1/Callose synthase, N-terminal domain superfamily [IPR023175]", "WD40-repeat-containing domain superfamily [IPR036322]", "WD40/YVTN repeat-like-containing domain superfamily [IPR015943]", "WGR domain superfamily [IPR036930]", "WIBG, N-terminal domain superfamily [IPR036348]", "WW domain superfamily [IPR036020]", "WWE domain superfamily [IPR037197]", "Winged helix DNA-binding domain superfamily [IPR036390]", "Winged helix-like DNA-binding domain superfamily [IPR036388]", "XPC-binding domain superfamily [IPR036353]", "YEATS superfamily [IPR038704]", "YjeF N-terminal domain superfamily [IPR036652]", "YqgF/RNase H-like domain superfamily [IPR037027]", "ZPR1, A/B domain [IPR042451]", "ZPR1, zinc finger domain [IPR042452]", "Zinc finger C2H2 superfamily [IPR036236]", "Zinc finger, C2H2C-type superfamily [IPR036060]", "Zinc finger, CCCH-type superfamily [IPR036855]", "Zinc finger, CCHC-type superfamily [IPR036875]", "Zinc finger, FYVE/PHD-type [IPR011011]", "Zinc finger, NHR/GATA-type [IPR013088]", "Zinc finger, PARP-type superfamily [IPR036957]", "Zinc finger, RING/FYVE/PHD-type [IPR013083]", "Zinc finger, RanBP2-type superfamily [IPR036443]", "Zinc finger, Sec23/Sec24-type superfamily [IPR036174]", "Zinc finger, ZZ-type superfamily [IPR043145]", "Zinc-binding ribosomal protein [IPR011332]", "dUTPase-like superfamily [IPR036157]", "eRF1, domain 1 [IPR024049]", "eRF1, domain 2 superfamily [IPR042226]", "p53-like tetramerisation domain superfamily [IPR036674]", "p53-like transcription factor, DNA-binding [IPR008967]", "p53/RUNT-type transcription factor, DNA-binding domain superfamily [IPR012346]", "rRNA adenine dimethylase-like, C-terminal [IPR023165]", "ssDNA-binding transcriptional regulator [IPR009044]", "tRNA (guanine-N1-)-methyltransferase, N-terminal [IPR029026]", "tRNA methyltransferase TRM10-type domain superfamily [IPR038459]", "tRNA methyltransferase, Trm1, C-terminal [IPR042296]", "tRNA modification GTPase MnmE domain 2 [IPR027368]", "tRNA-splicing ligase RtcB-like superfamily [IPR036025]", "von Willebrand factor A-like domain superfamily [IPR036465]"], "available_proteins": ["AAAS", "AACS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK6", "AKAP1", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG5", "ALKBH5", "ALYREF", "AMPD2", "ANAPC1", "ANAPC2", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOBEC3C", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6", "ARL8A", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ASCC1", "ASCC3", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATIC", "ATP11C", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5H", "ATP5O", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATP6V1H", "ATXN10", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCL2L13", "BCOR", "BCS1L", "BDH2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BOLA2*", "BOP1", "BPTF", "BRD1", "BRD2", "BSG", "BTF3", "BUB1B", "BUB3", "BZW1", "BZW2", "C1QBP", "CAB39", "CACNA2D1", "CACYBP", "CAD", "CALR", "CALU", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASK", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDKAL1", "CEBPZ", "CELF1", "CEP170", "CEPT1", "CERS2", "CFL1", "CFL2", "CHAF1B", "CHAMP1", "CHD1", "CHD1L", "CHD4", "CHD7", "CHEK2", "CHERP", "CHID1", "CHKA", "CHORDC1", "CHTF18", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLIC1", "CLIC4", "CLINT1", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT7", "CNOT9", "CNP", "COA7", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPZ1", "CORO1C", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTF1", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC22", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYP51A1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBR1", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCPS", "DCTN1", "DCUN1D1", "DCXR", "DDB1", "DDI2", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHFR", "DHRS13", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX34", "DHX35", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DIP2B", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC17", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DOCK1", "DOCK7", "DOHH", "DPH5", "DPM1", "DPYSL2", "DR1", "DRG1", "DRG2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "DYNLL2", "DYNLT1", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC4", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3B", "EIF3E", "EIF3G", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERCC6L", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC6", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FAF1", "FAF2", "FAH", "FAHD1", "FAM120A", "FAR1", "FARP2", "FARSA", "FARSB", "FASN", "FBL", "FBXO7", "FCGRT", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FH", "FKBP10", "FKBP4", "FKBP5", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNDC3A", "FNTB", "FOXRED1", "FRG1", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCLM", "GCN1", "GDAP1", "GDAP2", "GDI1", "GDI2", "GDPD1", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GGH", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLB1L2", "GLDC", "GLO1", "GLOD4", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GNS", "GORASP2", "GOT1", "GOT2", "GPD1L", "GPD2", "GPHN", "GPI", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GTF2F1", "GTF2I", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HEBP2", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMCES", "HMGB1", "HMGB2", "HMGB3", "HMGCR", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA12A", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPB11", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDE", "IDI1", "IFIT5", "IFNGR1", "IFT27", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMP3", "IMPDH2", "INTS1", "INTS14", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQSEC1", "IRF2BPL", "IRS4", "ISOC1", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "IWS1", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIAA0368", "KIF11", "KIF14", "KIF18A", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "KYAT3", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIG3", "LIN28B", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRSAM1", "LRWD1", "LSM14A", "LSM2", "LSM4", "LSM6", "LSM7", "LSM8", "LSS", "LTA4H", "LYAR", "LYPLA1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MANBA", "MANF", "MAP2K1", "MAP2K4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAU2", "MBD3", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDC1", "MDH1", "MDH2", "MDN1", "ME2", "MECP2", "METTL13", "METTL16", "MFN1", "MFN2", "MFSD10", "MFSD14B", "MFSD3", "MFSD5", "MFSD8", "MGAT1", "MGEA5", "MGME1", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MIPEP", "MKI67", "MKRN2", "MMS19", "MOB4", "MOGS", "MORC2", "MORF4L1", "MORF4L2", "MOV10", "MPG", "MPHOSPH8", "MPI", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL38", "MRPL39", "MRPL43", "MRPL44", "MRPL45", "MRPL47", "MRPL9", "MRPS11", "MRPS15", "MRPS17", "MRPS2", "MRPS25", "MRPS27", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MUT", "MYBBP1A", "MYCBP2", "MYEF2", "MYH10", "MYH9", "MYL6", "MYL6B", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA40", "NAA50", "NAE1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NCAPD2", "NCAPD3", "NCAPG", "NCBP1", "NCBP3", "NCDN", "NCL", "NCOA5", "NDRG3", "NDUFA10", "NDUFA9", "NDUFAF1", "NDUFS1", "NDUFS3", "NDUFV2", "NECAP2", "NEDD4L", "NEK9", "NELFE", "NENF", "NF1", "NFATC2IP", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIPSNAP2", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL8", "NOL9", "NOM1", "NONO", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NOVA2", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUB1", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUP133", "NUP153", "NUP155", "NUP188", "NUP210", "NUP214", "NUP37", "NUP43", "NUP50", "NUP98", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC5", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXCT1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B1", "PAFAH1B3", "PAIP1", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PAPSS2", "PARK7", "PARN", "PARP1", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCMT1", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDZD11", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF3", "PHF6", "PHGDH", "PHIP", "PI4KA", "PICALM", "PIK3C2A", "PIK3R4", "PIR", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLRG1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNO1", "PNP", "PNPT1", "POGZ", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "PON2", "POP7", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL4", "PPM1F", "PPM1G", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRKAA1", "PRKACA", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRSS3", "PRTFDC1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD2", "PSMD3", "PSMD6", "PSME1", "PSME2", "PSME3", "PSME4", "PSPC1", "PTBP1", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PUS7", "PWP1", "PWP2", "PYCR1", "PYCR2", "PYM1", "QARS", "QKI", "QPRT", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB23", "RAB2A", "RAB35", "RAB3B", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "REPS1", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIDA", "RIF1", "RIPK1", "RMDN1", "RNASEH2A", "RNASET2", "RNF14", "RNF2", "RNF20", "RNF219", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK1", "RPA1", "RPA2", "RPAP3", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS3", "RPS4X", "RPS5", "RPS6KA1", "RPS6KA3", "RPS8", "RPS9", "RPSA", "RREB1", "RRM1", "RRM2", "RRP12", "RRP8", "RRP9", "RSF1", "RSL1D1", "RSL24D1", "RSU1", "RTCB", "RTN4IP1", "RUVBL1", "RUVBL2", "S100A11", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART3", "SBDS", "SBNO1", "SCAF11", "SCAF4", "SCCPDH", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCYL2", "SDAD1", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC13", "SEC14L2", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3B1", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGPL1", "SGTA", "SH3BGRL", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHMT2", "SIL1", "SIN3A", "SIRT1", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC2A1", "SLC30A7", "SLC3A2", "SLC9A3R1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMU1", "SMYD3", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNX1", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPART", "SPECC1", "SPECC1L", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3", "STARD7", "STAT1", "STAT3", "STIP1", "STMN1", "STOML2", "STRAP", "STRBP", "STUB1", "STX12", "STX4", "STX5", "STX7", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SV2A", "SWAP70", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "TAB1", "TAF15", "TAF2", "TAF5", "TAF6L", "TAGLN2", "TALDO1", "TAOK1", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D15", "TBC1D4", "TBC1D8B", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBK1", "TBL2", "TBL3", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCF25", "TCP1", "TECR", "TELO2", "TERF2IP", "TEX10", "TFAM", "TFB1M", "TFRC", "THEM6", "THOC1", "THOC3", "THOC6", "THOP1", "TIA1", "TIAL1", "TIGAR", "TIMM44", "TIMM50", "TJP1", "TK1", "TKT", "TLN1", "TMA16", "TMED2", "TMED5", "TMED7", "TMEM115", "TMEM14C", "TMOD3", "TMPO", "TMPO", "TMPPE", "TMTC3", "TMX1", "TMX2", "TMX4", "TNPO1", "TNPO3", "TOMM20", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1AIP2", "TOX4", "TP53", "TP53BP1", "TP53BP2", "TPD52L2", "TPI1", "TPM4", "TPP1", "TPP2", "TPRKB", "TPT1", "TRA2A", "TRA2B", "TRAP1", "TRAPPC4", "TRAPPC5", "TRAPPC8", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSNAX", "TSPAN6", "TSPO", "TSPYL1", "TST", "TSTA3", "TTC1", "TTC19", "TTC21B", "TTC26", "TTC27", "TTC37", "TTC38", "TTC4", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWNK", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNL4A", "TXNRD1", "TXNRD2", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBFD1", "UBL5", "UBLCP1", "UBQLN4", "UBR1", "UBR4", "UBR5", "UBTF", "UBXN4", "UCHL5", "UFD1", "UFM1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP33", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIRMA", "VPS16", "VPS25", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4A", "VPS4B", "VRK1", "VRK3", "VTA1", "VWA8", "WAPL", "WARS", "WARS2", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR70", "WDR75", "WDR77", "WDR82", "WFS1", "WIZ", "WNK1", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "YARS", "YARS2", "YBX1", "YBX3", "YEATS2", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC2", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBTB10", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3HAV1", "ZCCHC3", "ZCRB1", "ZFR", "ZFYVE16", "ZMYND8", "ZNF512", "ZNF512B", "ZNF638", "ZNF687", "ZPR1", "ZRANB2"], "leading_proteins": ["AARS2", "ACAD11", "ACLY", "ACP2", "AGL", "AKT2", "ANAPC5", "ANAPC7", "ANKLE2", "ANKRD17", "ANXA1", "ANXA11", "ARFGAP2", "ARHGEF7", "ASCC1", "ASCC3", "BSG", "CACYBP", "CAD", "CALU", "CARM1", "CASK", "CCNB1", "CDC16", "CDC23", "CDK11B", "CERS2", "CHKA", "CIRBP", "CLUH", "CNNM4", "COA7", "COMT", "CRTAP", "CTSA", "CTSB", "CYB5B", "CYB5D2", "DCUN1D1", "DIAPH3", "DNAJA2", "DNAJB11", "DNAJC2", "DNAJC8", "DNAJC9", "ECE1", "EHD4", "EIF3L", "EIF4B", "EPHX1", "ERAP2", "EWSR1", "EXO1", "EXOSC8", "F11R", "FARP2", "FARSA", "FCGRT", "FH", "FKBP10", "FMR1", "FN3KRP", "FNTB", "FOXRED1", "FUBP1", "FUBP3", "FUCA2", "FUS", "FXR1", "FXR2", "GAA", "GAK", "GALNT7", "GBA", "GGH", "GLA", "GLB1", "GLB1L2", "GLDC", "GLOD4", "GSTM3", "GSTO1", "GUSB", "HACD3", "HDAC2", "HEXA", "HGS", "HLA-A", "HLA-B", "HLA-C", "HMOX2", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPR", "HNRNPUL2", "HSPB1", "IFNGR1", "IGF2BP2", "IGF2BP3", "KDM1B", "KDM5A", "KHDRBS1", "KHDRBS3", "KHSRP", "KMT2A", "KPNA1", "KPNA3", "KPNA4", "LANCL1", "LARP4", "LARP7", "LGALS3", "LMAN2", "LNPEP", "LPCAT1", "LRBA", "LRP1", "LTA4H", "MAP2K1", "MAP2K4", "MAPRE2", "MATR3", "MAU2", "MFSD3", "MFSD8", "MGEA5", "MID1", "MINDY3", "MKRN2", "MPP2", "MRPL39", "MRPS7", "MSH2", "MSH6", "MTMR6", "MTOR", "MTPAP", "MYH10", "MYH9", "MYL6", "NAA40", "NAGLU", "NAP1L1", "NAP1L4", "NENF", "NIP7", "NLN", "NPEPPS", "NSD2", "NSUN2", "NTMT1", "NUCB2", "OLA1", "OTUB1", "P3H1", "P3H4", "P4HA1", "PABPC1", "PABPC4", "PANK4", "PAPOLA", "PBK", "PCYOX1", "PDCL3", "PDE6D", "PFAS", "PFDN4", "PFDN6", "PFN2", "PGRMC2", "PHF6", "PI4KA", "PIR", "PITHD1", "PLA2G15", "POLR2C", "PON2", "PPM1G", "PPT1", "PPT2", "PRCP", "PRKAR1A", "PRPF40A", "PSMA3", "PSMA6", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMD10", "PSMD11", "PSME2", "PTGES2", "PTPN11", "PTPRF", "PUF60", "PUS7", "QKI", "RAI14", "RBM10", "RBM14", "RBM3", "RBM4", "RBM5", "RBMX", "RBPJ", "RCN2", "REPS1", "RMDN1", "RNF20", "SCPEP1", "SEPHS1", "SGPL1", "SGTA", "SLC16A1", "SLC25A10", "SLC25A15", "SLC25A20", "SLC25A26", "SLC25A32", "SMYD3", "SPART", "SPTLC2", "SRSF9", "STAM", "SUCLG1", "SUCLG2", "SYNCRIP", "TAB1", "TAF15", "TAOK1", "TBC1D9B", "TCAF1", "TCF25", "THOP1", "TIA1", "TIAL1", "TMX4", "TRA2B", "TRIM21", "TRIM25", "TTC1", "TTC19", "TTC27", "TTC37", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TXNDC12", "UNC119", "UNC119B", "USP24", "USP28", "USP33", "USP47", "VBP1", "VDAC1", "WFS1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAZ", "ZADH2", "ZC3H18", "ZC3H7A"]} \ No newline at end of file diff --git a/interpro_ptm/advanced/idx2term.json b/interpro_ptm/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/advanced/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/basic/idx2term.json b/interpro_ptm/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..9e26dfeeb6e641a33dae4961196235bdb965b21b --- /dev/null +++ b/interpro_ptm/basic/idx2term.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/interpro_ptm/consensus.joblib b/interpro_ptm/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..333a1214d8199639769ac4ef25550751a73ab5e1 --- /dev/null +++ b/interpro_ptm/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:907265680688ad7abb03348b197f1f14d3f3c539b6c7f46c22bed4a159039f12 +size 61933 diff --git a/interpro_ptm/df_merge.tsv b/interpro_ptm/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/interpro_ptm/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/interpro_ptm/metrics.json b/interpro_ptm/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..440404fe976e3da4873185fa5bee3d71cd2f3523 --- /dev/null +++ b/interpro_ptm/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2812, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 2.25 +} \ No newline at end of file diff --git a/interpro_ptm/paths.json b/interpro_ptm/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..ac67eb482e41bf933d185404b10f618372d7c9af --- /dev/null +++ b/interpro_ptm/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_ptm/fragment/C428/C428_val_log2fc"} \ No newline at end of file diff --git a/interpro_ptm/result.tsv b/interpro_ptm/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..911c0f98110fcfc0055bf4e7c9370c039a6363c6 --- /dev/null +++ b/interpro_ptm/result.tsv @@ -0,0 +1 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size diff --git a/interpro_ptm/selections.json b/interpro_ptm/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..d2d6b84f22d76b5bbdd605592c031bf878bf2743 --- /dev/null +++ b/interpro_ptm/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["EGF-type aspartate/asparagine hydroxylation site [IPR000152]", "P-type ATPase, phosphorylation site [IPR018303]", "Phosphopantetheine attachment site [IPR006162]", "Translation elongation factor, IF5A, hypusine site [IPR019769]"], "available_proteins": ["ATP11C", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "EIF5A", "FASN", "LRP1", "SLIT2"], "leading_proteins": []} \ No newline at end of file diff --git a/interpro_repeat/advanced/idx2term.json b/interpro_repeat/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6dce773863970e13dd9ed6c0019ab4c4e97de280 --- /dev/null +++ b/interpro_repeat/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Mitochondrial substrate/solute carrier [IPR018108]"} \ No newline at end of file diff --git a/interpro_repeat/advanced/plot_0.png b/interpro_repeat/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..2fc648839ab1f91add95d8f607ebc9d7bb4e9dec --- /dev/null +++ b/interpro_repeat/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:0bdad571ee13e6025cc6f1a984727fa1b6fa78bc9dc74545da7a1f08e38d7dbc +size 188715 diff --git a/interpro_repeat/basic/idx2term.json b/interpro_repeat/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..6dce773863970e13dd9ed6c0019ab4c4e97de280 --- /dev/null +++ b/interpro_repeat/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Mitochondrial substrate/solute carrier [IPR018108]"} \ No newline at end of file diff --git a/interpro_repeat/basic/plot_0.png b/interpro_repeat/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..cb545af6af5d7ccf4477a983b8be05fc91eb612f --- /dev/null +++ b/interpro_repeat/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:5208a2107cdc8a2e2ffd047e202462ffd2402eafb428badacca62f5dfab56cec +size 145195 diff --git a/interpro_repeat/consensus.joblib b/interpro_repeat/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..12791fc9f21a6075b74caf31c15b3f3a5c5b2be0 --- /dev/null +++ b/interpro_repeat/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:1f361091750a506bfe5427dfabc492aaffee640d37f62deb39ffafd10e667dc7 +size 71277 diff --git a/interpro_repeat/df_merge.tsv b/interpro_repeat/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..9e71ace7a5252f2257485255a341f124333e8ad6 --- /dev/null +++ b/interpro_repeat/df_merge.tsv @@ -0,0 +1,4 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Mitochondrial substrate/solute carrier [IPR018108] 5 19 2.715462998856286 0.0066183171553393 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 0.0278614928576642 0.1706778675257841 0.005693097574516 0.0002680304953179 0.0093317531476842 +Armadillo [IPR000225] 3 15 2.317897788328067 0.0204548766836254 5.961165048543689 15.74757281553398 -0.3777191709644164 0.6124516221766493 3.618110674959256 1.7416566524959318 0.7191645991778066 0.2988828999573438 0.0012137684605766 0.0004528325246922 0.0031841845740684 0.0062346640440273 0.0612536211646263 +Atypical Arm repeat [IPR032413] 3 5 2.148923203572935 0.0316404881232532 1.900485436893204 4.162621359223301 -0.0859723492776628 0.5961263336607893 1.2157141643493203 0.6792778306365289 0.8334835296312452 0.3002751483750439 6.1078318265291925e-06 2.196659839709844e-06 1.6865595784317113e-05 4.77609685109951e-06 7.614857799780336e-05 diff --git a/interpro_repeat/metrics.json b/interpro_repeat/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..b55722bf83ca8f12a0728bef0606beae98119b94 --- /dev/null +++ b/interpro_repeat/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2812, + "annotations_size": 74, + "title": "Average number of proteins per term", + "value": 5.108108108108108 +} \ No newline at end of file diff --git a/interpro_repeat/paths.json b/interpro_repeat/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..e88b989704aa740d49bd57c007a7cbdae1a234f3 --- /dev/null +++ b/interpro_repeat/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/interpro_repeat/fragment/C428/C428_val_log2fc"} \ No newline at end of file diff --git a/interpro_repeat/result.tsv b/interpro_repeat/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..ecfb16a41d020a09f90c49d99b4349705f733a53 --- /dev/null +++ b/interpro_repeat/result.tsv @@ -0,0 +1,9 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Mitochondrial substrate/solute carrier [IPR018108] 0.7013351530970566 2.715462998856286 0.0066183171553393 0.3882204871274227 0.108795405149921 19 Q70HW3,O43772,Q9Y619,Q9UBX3,Q9H2D1 5 +Armadillo [IPR000225] 0.6787227704339933 2.317897788328067 0.0204548766836254 0.7833248705707566 0.108795405149921 15 O00505,O00629,P52294 3 +Atypical Arm repeat [IPR032413] 0.9176634815703018 2.148923203572935 0.0316404881232532 0.9073788667576492 0.1415076660312808 5 O00505,O00629,P52294 3 +HEAT repeat [IPR000357] 0.7170824868805102 0.9628827791755924 0.3356063525743278 0.9999999999999276 0.6367915407820579 4 P30154 1 +HEAT, type 2 [IPR021133] 0.4556271042579763 0.7931974657169578 0.4276627838237536 1.0 0.6772359316371238 11 Q9BU89,P30154 2 +Annexin repeat [IPR018502] 0.4481152811367704 0.5219084417124175 0.601734080403064 1.0 0.7677296887901162 7 P50995,P04083 2 +Pentatricopeptide repeat [IPR002885] 0.4141737891737921 0.0770081239081242 0.9386170822175162 1.0 1.0 4 O75127,Q92552,P42704 3 +Leucine-rich repeat [IPR001611] 0.2651001659735398 0.0032894102695921 0.9973754350648084 1.0 1.0 18 Q92696,Q9UFC0 2 diff --git a/interpro_repeat/selections.json b/interpro_repeat/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..0e9b902e1bd7df33062b531e9769022f34e66d5d --- /dev/null +++ b/interpro_repeat/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Ankyrin repeat [IPR002110]", "Annexin repeat [IPR018502]", "Armadillo [IPR000225]", "Atypical Arm repeat [IPR032413]", "BIR repeat [IPR001370]", "Calponin repeat [IPR000557]", "Cation-independent mannose-6-phosphate receptor repeat [IPR000479]", "Chromosome region maintenance repeat [IPR041123]", "Clathrin, heavy chain, propeller repeat [IPR022365]", "Clathrin, heavy chain/VPS, 7-fold repeat [IPR000547]", "Collagen triple helix repeat [IPR008160]", "Cysteine-rich Golgi apparatus protein 1 repeat [IPR001893]", "Cysteine-rich Golgi apparatus protein 1 repeat, eukaryote [IPR017873]", "Exportin-1, repeat 2 [IPR041235]", "Exportin-1, repeat 3 [IPR040485]", "Filamin/ABP280 repeat [IPR001298]", "Filamin/ABP280 repeat-like [IPR017868]", "Furin-like repeat [IPR006212]", "G-protein beta WD-40 repeat [IPR020472]", "GTF2I-like repeat [IPR004212]", "HAT (Half-A-TPR) repeat [IPR003107]", "HEAT repeat [IPR000357]", "HEAT repeat associated with sister chromatid cohesion protein [IPR026003]", "HEAT, type 2 [IPR021133]", "HUWE1/Rev1, ubiquitin binding region [IPR025527]", "Hexapeptide repeat [IPR001451]", "Hs1/Cortactin [IPR003134]", "Huntingtin, middle-repeat [IPR024613]", "Importin repeat 4 [IPR041653]", "Importin repeat 6 [IPR041389]", "Importin repeat [IPR040928]", "KI67R [IPR012568]", "Kelch repeat type 1 [IPR006652]", "Kinesin light chain repeat [IPR015792]", "LDLR class B repeat [IPR000033]", "Leucine rich repeat 4 [IPR025875]", "Leucine-rich repeat [IPR001611]", "Leucine-rich repeat, cysteine-containing subtype [IPR006553]", "Leucine-rich repeat, typical subtype [IPR003591]", "Low-density lipoprotein (LDL) receptor class A repeat [IPR002172]", "Mbt repeat [IPR004092]", "Microtubule associated protein, tubulin-binding repeat [IPR001084]", "Mitochondrial substrate/solute carrier [IPR018108]", "NHL repeat [IPR001258]", "Nebulin repeat [IPR000900]", "Neuraxin/MAP1B repeat [IPR000102]", "P120R repeat [IPR012586]", "PBS lyase HEAT-like repeat [IPR004155]", "PFTB repeat [IPR001330]", "PQ-loop repeat [IPR006603]", "Paired amphipathic helix [IPR003822]", "Pentatricopeptide repeat [IPR002885]", "Plectin repeat [IPR001101]", "Proteasome/cyclosome repeat [IPR002015]", "Protein of unknown function DM15 [IPR006607]", "Protein prenyltransferase, alpha subunit [IPR002088]", "Proteinase inhibitor I27, calpastatin [IPR001259]", "Pumilio RNA-binding repeat [IPR001313]", "Putative TPR-like repeat [IPR031545]", "Pyrrolo-quinoline quinone repeat [IPR002372]", "RNA helicase p68 repeat [IPR012587]", "RNA polymerase II, heptapeptide repeat, eukaryotic [IPR000684]", "Regulator of chromosome condensation, RCC1 [IPR000408]", "Ribonuclease inhibitor, leucine rich repeat cap [IPR041302]", "Sel1-like repeat [IPR006597]", "Spectrin repeat [IPR002017]", "Spectrin/alpha-actinin [IPR018159]", "Tetratricopeptide repeat 1 [IPR001440]", "Tetratricopeptide repeat 2 [IPR013105]", "Tetratricopeptide repeat [IPR019734]", "Vesicle tethering protein p115, armadillo tether-repeat [IPR041209]", "WD40 repeat [IPR001680]", "Wolframin, Sel1-like repeat [IPR045458]", "Zinc finger, C2H2C-type [IPR002515]"], "available_proteins": ["AAAS", "AAMP", "ACTN1", "ACTN4", "AIP", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKRD17", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP2B1", "ARMC6", "ARMCX3", "ARPC1A", "ASPH", "BCOR", "BIRC6", "BOP1", "BUB3", "CAST", "CDC16", "CDC23", "CDC27", "CHAF1B", "CKAP5", "CLASP1", "CLPB", "CLTC", "CNN2", "CNN3", "COA7", "COLEC12", "COPA", "COPB2", "CORO1C", "CRNKL1", "CSTF1", "CSTF3", "CTNNB1", "CTNND1", "CTR9", "CTTN", "DCAF13", "DCAF7", "DDX5", "DNAAF5", "DNAJC3", "DNAJC7", "DOHH", "DSP", "EDC4", "EHMT1", "EIF2B5", "EIF3I", "ELP2", "EMC1", "EMC2", "EML4", "EPPK1", "FKBP4", "FKBP5", "FKBP8", "FLII", "FLNA", "FLNB", "FLNC", "FNTA", "FNTB", "GCN1", "GEMIN5", "GLG1", "GLS", "GMPPA", "GRWD1", "GTF2I", "GTF3C2", "GTF3C3", "HCFC1", "HECTD1", "HTT", "HUWE1", "IFIT5", "IGF1R", "IGF2R", "IPO4", "IPO5", "JUP", "KAT7", "KDELC2", "KDM2A", "KLC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "LARP1", "LASP1", "LLGL1", "LRBA", "LRP1", "LRPPRC", "LRRC40", "LRRC47", "LRRC59", "LRSAM1", "LRWD1", "MACF1", "MAP1B", "MAP4", "MAU2", "MKI67", "MPDU1", "MPHOSPH8", "MRPS27", "MTCH1", "MTCH2", "MTPN", "MYCBP2", "NAA15", "NASP", "NEK9", "NHLRC2", "NIPBL", "NLE1", "NOL10", "NOP2", "NOP9", "NUDT12", "NUP214", "NUP37", "NUP43", "NXF1", "OGT", "P4HA1", "PAFAH1B1", "PAK1IP1", "PDCD11", "PHIP", "PIK3R4", "PLAA", "PLEC", "PLRG1", "POLR2A", "PPID", "PPP1R12A", "PPP1R7", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP5C", "PREB", "PRKCSH", "PRPF19", "PRPF4", "PRPF6", "PSMD1", "PSMD10", "PSMD2", "PTCD1", "PTCD3", "PUM1", "PUM3", "PWP1", "PWP2", "RABGGTA", "RACK1", "RAE1", "RAI14", "RANBP2", "RANGAP1", "RAP1GDS1", "RBBP5", "RCC1", "RCC2", "RNH1", "RPAP3", "RRP9", "RSU1", "SART3", "SCML2", "SCRIB", "SEC13", "SEC31A", "SEH1L", "SGTA", "SIN3A", "SKP2", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLIT2", "SMU1", "SNRNP40", "SNRPA1", "SPTAN1", "SPTBN1", "SRP72", "STIP1", "STRAP", "STUB1", "SUGT1", "SYNE2", "TAF5", "TAGLN2", "TBL2", "TBL3", "TEX10", "THOC3", "THOC6", "TMTC3", "TOMM34", "TOMM70", "TP53BP2", "TTC1", "TTC19", "TTC21B", "TTC26", "TTC27", "TTC37", "TTC4", "UNC45A", "USO1", "UTP15", "UTP18", "UTP4", "UTP6", "UTRN", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR43", 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setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Sphingolipid metabolic process 10 25 3.2765927785689777 0.0010506778657519 12.631067961165048 29.174757281553397 1.3566630100256978 0.1614907042591146 4.986857078326301 3.461093559903884 2.232073980338918 0.2503191978902473 0.136060560743451 0.3713777336871285 0.0126614085231583 8.5039555642666e-05 0.0018998026291165 +Membrane lipid metabolic process 11 32 3.23367140447041 0.0012220997700467 15.813106796116504 37.71116504854369 1.423850539998867 0.1808469841706369 6.252884620395072 4.742042041181393 2.289538519382486 0.2724480316274368 0.1991860227566836 0.4475497772550058 0.028278569718715 0.0001474197538178 0.0019842175144136 +Hormone metabolic process 5 28 3.1854220134403133 0.0014454305605768 8.95631067961165 28.65776699029126 1.130508313948193 0.2963365150575847 3.9674689274001818 2.5345884681715156 1.346801337886388 0.3240077568826507 0.0043689110127939 0.0118439766153403 0.0003301094964348 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1.0253621290577795e-05 3.357989565458091e-05 0.0034040770862524 +Negative regulation of multicellular organismal process 22 94 2.6288609515374817 0.008567138300032 18.75728155339806 105.0873786407767 -0.2928772776162281 0.6614464056408763 7.687735812996985 12.497849753788916 0.7546000625094377 0.3272041972626839 0.3890158048734349 0.3938946966793599 0.1534221629157393 0.2214375034604501 0.4730080672066392 +Nls bearing protein import into nucleus 3 9 2.621199546181102 0.0087620958541194 3.466019417475728 8.951456310679612 -0.0457641820443717 0.6667329588646846 2.3402992671487843 0.8170351417463786 0.7089065078120066 0.2839241774036851 0.0001627882362757 5.941460259222129e-05 0.000440337804097 0.0004788146962384 0.0062633876942655 +Chloride transport 3 10 2.614915952606417 0.0089249414373866 4.33252427184466 12.12621359223301 1.0302584084066435 0.2341882174183942 2.3624510960969567 2.26059366569241 1.2797232968088257 0.2563105728143979 0.0213895916673822 0.1499686155438198 0.0398064357050217 0.0078094686864188 0.07392944267488 +Mitochondrial transport 12 77 2.603516146943274 0.0092272921023919 26.76456310679612 83.42233009708738 1.9353944346565397 0.260698067067068 11.29934298946582 6.8259418360610375 1.9296757414965091 0.3685496297416806 0.0059925172839003 0.001367376809486 0.0056874611143685 0.0002227949702616 0.0173998307196362 +Ph reduction 4 12 2.6002253124893464 0.0093162570147455 4.422330097087379 12.509708737864075 1.1966830084586066 0.1930048880851129 1.91475781321527 1.7851607614701208 1.4167744165903868 0.2497649393583847 3.683321051409648e-05 0.0082126449787597 0.0001376480525375 0.0004897389809093 0.010278445998416 +Vacuolar acidification 4 9 2.5998414171499395 0.0093266849876263 3.4757281553398056 8.922330097087379 1.27407749822917 0.1611429668415415 1.4148632661931722 1.303016071016461 1.4195929612668792 0.2212670077717619 5.797443454880553e-06 0.0034296220851759 2.214575962840231e-05 5.200397996359343e-05 0.0013369974246366 +Rna stabilization 13 28 2.5799781144228406 0.0098806576843526 9.359223300970871 27.37621359223301 0.4792302048577673 0.5262457931829767 4.411160534464403 1.6856669427134765 1.0994939820726763 0.3614208213771557 0.287065986663278 1.0 0.0803922289273931 0.0001580597168237 1.7163900968398735e-05 +Negative regulation of mrna catabolic process 11 27 2.557200958321535 0.0105518239723567 9.169902912621358 24.631067961165048 0.5652120707700043 0.4958815262040553 4.097153521759381 1.8459627491120816 1.1372403168685192 0.3560626632344691 0.2670540153627264 1.0 0.0693457394610891 9.063996119237736e-05 9.950941556486035e-07 +Regulation of response to external stimulus 41 117 2.537856411290007 0.0111533735137678 27.32766990291262 129.63349514563106 0.3937649860570471 0.6986677015868525 9.316542933972368 15.399506498758855 0.8616366228871625 0.3591499966721317 0.3464343629550839 0.6332377591618767 0.1226660163399909 0.0330145457652952 0.0066761071810752 +Peptide catabolic process 7 10 2.5112095225708795 0.0120318260993763 3.871359223300971 10.351941747572816 1.5413280472635258 0.1625248535751528 1.454973091229298 0.9501768442987896 1.1353491763523988 0.2229381591694359 0.1227903182841607 0.0892490045576324 0.014058804472369 0.0101015401572799 1.372168527141767e-06 +Protein import into mitochondrial matrix 1 9 2.50520592970539 0.012238011748993 3.3276699029126213 9.03883495145631 1.4677455160780188 0.1396272549365287 1.9612536628062327 0.7162785445212654 1.2893924319512868 0.2212161399323651 0.0046050017435412 0.0023758658868836 0.0088504827764808 0.0495157384890535 0.1630814235328921 +Regulation of pattern recognition receptor signaling pathway 7 16 2.5051099279999143 0.0122413340794509 4.691747572815534 19.70873786407767 0.80673262224624 0.4173389113947272 2.517825740704142 3.173406084005513 0.919675411949683 0.3119180769844089 1.0 1.0 0.4515227909961177 0.0622490701590107 0.0098122663634215 +Detection of stimulus 5 12 2.502958478140233 0.0123159992156691 3.703883495145631 15.094660194174756 0.4988421371496737 0.4953505375843557 2.0878019439832904 2.71158439534448 0.904437685812264 0.3029606195069137 0.0713574232799365 0.0391768542263283 0.1258733376055511 0.0043231258251732 0.0347439304052366 +Peptidyl tyrosine modification 12 31 2.499455331912581 0.0124384378683306 8.70388349514563 37.73543689320388 -0.0239454267802142 0.6861916771215885 4.618418641018608 5.785435895284358 0.6551498843976254 0.2777474877708394 1.0 1.0 0.8446675734226833 0.8441742661356123 0.2180007355816905 +Cytokine production 26 89 2.4611163937764764 0.0138505424241985 18.97087378640777 96.13106796116504 0.0824735848580317 0.7508975178485808 7.48909409104055 11.178920255675855 0.680456448776925 0.3062861740716413 0.9008407480518164 0.8077735352513418 0.0978323244448722 0.0290196546140146 0.0054625659467542 +Cellular response to biotic stimulus 11 32 2.460797110987806 0.0138628736138304 8.070388349514563 35.616504854368934 0.7964477296470692 0.4798420500319036 3.1871094803090645 3.824235365857021 0.8467616012566905 0.3489796792314515 0.0424761086814764 0.1058856107488554 0.023308813864781 0.1375852211603767 0.1830009986928179 +Circulatory system process 15 65 2.454233312519845 0.0141185345081569 17.152912621359224 72.00970873786407 0.7968086684699157 0.4206667688960129 5.8797345113877215 8.195718922280731 1.282615010632819 0.3676426088525382 0.0250782673404935 0.0304145205249448 0.0022466657765122 0.1314165938502621 0.1297851082773875 +Protein targeting to mitochondrion 7 44 2.452260149182054 0.0141961985982326 14.980582524271844 46.067961165048544 1.7767024064550243 0.249920045184344 6.494927942714517 4.708517660750424 1.5433015545903224 0.3384144763122346 0.0030791546798053 0.0008814481157451 0.0101118666995626 0.0012481596775334 0.0265567637490863 +Establishment of protein localization to mitochondrial membrane 3 12 2.4400284914508648 0.0146861035822629 5.572815533980583 16.524271844660195 1.1986544459127668 0.291784793504827 2.8501471321161915 2.5441524813639957 1.2232399066733852 0.3232066755573589 0.1699293347786211 0.1244478155008913 0.2297987482657219 0.0037492480554313 0.0397044670530444 +Protein transmembrane transport 5 21 2.421350446166394 0.0154629622271973 8.992718446601941 25.191747572815533 1.6893060623430327 0.189108476986505 4.473486660459625 2.7693940759543416 1.4682653164365471 0.2783169275392022 0.0056801747873364 0.0021878047045258 0.0142561824639166 0.0087768454005906 0.0423415641222214 +Liposaccharide metabolic process 6 15 2.4008463045900794 0.0163572051352991 7.393203883495145 16.839805825242717 0.7162233803449398 0.1804705798886219 2.8837934205508033 2.921890590438037 1.8930166841377585 0.2403675114219934 1.0 1.0 0.4297892617739207 0.0127222619547071 0.0215069931551279 +Membrane lipid biosynthetic process 4 20 2.394667609602732 0.0166354382627547 8.866504854368932 23.050970873786408 1.3229385051208649 0.2431293012321725 4.229937732502716 3.4850337476777224 1.635527795490498 0.2996124846932806 0.4328724345687331 0.3328373805982222 0.1862598674919939 0.0478393395788808 0.3672559590554952 +Positive regulation of cellular amide metabolic process 17 58 2.3862053460327632 0.0170232427889578 15.269417475728156 63.57281553398058 0.1930311724534189 0.6742726413522647 7.234138098598721 5.065784601240607 0.7801714000419192 0.3214100330847041 0.2142555661220106 0.4637995473310806 0.1209939299005533 0.0033982880419941 3.511391403057467e-05 +Mitochondrion organization 27 155 2.376459838435637 0.0174796641278947 56.45873786407767 188.26941747572815 1.5905300936136977 0.4100157441778524 20.15716756472138 18.40319032732565 2.034523716094369 0.4327537677377048 0.0007187731277997 3.98760466822691e-05 0.0009087268792705 0.000131892731254 0.0006070846708172 +Secondary alcohol metabolic process 10 38 2.374032340297624 0.0175950093113299 12.097087378640778 42.24514563106796 1.5200936296432006 0.2566232504859334 4.463475425703621 3.883072640851752 1.3223501002339118 0.3210874999447533 0.0029543089567506 0.0677466229044455 0.0001822132476349 7.1616025702379925e-06 6.932056766391408e-05 +Cellular response to molecule of bacterial origin 9 25 2.37086591494438 0.0177464678221039 5.966019417475728 27.81553398058253 0.5401337963874872 0.5564422286794936 2.8066859633222845 3.421796419175491 0.7983543896720936 0.3278075181218943 0.1268058928280048 0.0718661948949039 0.0555648452334619 0.1723284412806655 0.1466425101977657 +Regulation of immune response 37 112 2.365184510298969 0.018021090182291 25.00242718446602 119.80339805825244 0.248728055937711 0.7234553499352745 8.655908467072013 12.491655004997526 0.7490545850270482 0.335364410227988 0.9358609055678268 0.8591357079848979 0.3228087848747342 0.0910163637734502 0.0006814816127139 +Response to food 2 5 2.3641575944130504 0.0180711235211321 1.720873786407767 5.783980582524272 1.3281223897944048 0.1823213242558801 0.9790282548915298 0.8299231919143666 1.0823564620426191 0.211054619984942 8.437657150247395e-05 0.0017760204843955 0.0002296483500821 0.0033170374819039 0.0225979674873623 +Iron ion homeostasis 4 16 2.3462500253692897 0.0189633818187873 4.468446601941747 17.140776699029125 1.0306963602610326 0.26770320823289 2.1032740346004313 1.762496954108992 1.1437451534606062 0.2692749918411525 0.0050990139544559 0.0257915242502586 0.0014189260290535 0.0074685925596388 0.1000707214680032 +Regulation of gliogenesis 1 11 2.3342871503433544 0.0195806911194347 2.5776699029126213 12.766990291262136 0.4275984781816435 0.4940387299474685 2.0387713813482975 2.058389810399436 0.9188590751221472 0.30630744557224 0.0460722283357764 0.0248568883498602 0.0832345551471358 0.3407321567572847 0.4404396671456285 +Insulin receptor signaling pathway 9 24 2.32283505121247 0.0201880153099429 6.410194174757281 27.196601941747577 0.4458503447638467 0.5800076074910292 3.334752718036452 4.318360902053531 0.801520614655186 0.3231564676168196 0.1087995400312557 0.0610672127355571 0.0442161560616649 0.1360002203186876 0.0175418047376826 +Protein transmembrane import into intracellular organelle 1 12 2.3127240869894483 0.0207378138311291 4.951456310679611 13.45631067961165 1.503963012554726 0.1758225015375162 2.735521961789203 1.4944992929031071 1.2360761671845495 0.245991671368161 0.0178558819218137 0.0093923264669034 0.0334071197556988 0.1627514901813832 0.4315495391205481 +Regulation of rna splicing 25 86 2.299924577637647 0.0214524933981992 27.91990291262136 86.5121359223301 0.1323494025528259 0.5572910110956871 9.72639747067558 5.208502039558804 1.4178017247437722 0.381677869420044 0.6051448342152391 1.0 0.3700525131557232 0.0003883038979166 1.0066348738962344e-09 +Negative regulation of mrna metabolic process 19 48 2.297281460889207 0.0216027186821647 15.78640776699029 45.30339805825243 0.4317654752348391 0.5186468695555119 6.004287279655988 2.910090931551649 1.3207774317424965 0.3775544483756486 0.3921075333889572 1.0 0.152127800544383 0.0003234494579858 2.4718436489194705e-07 +G protein coupled receptor signaling pathway 11 37 2.2953718395643192 0.021711823766745 8.648058252427184 44.101941747572816 -0.3770970612337289 0.4144255329514536 3.971368539216243 6.416702727999738 1.221530317440595 0.3246076536357387 1.0 1.0 0.8832882739345362 0.7821321804469274 0.3811939909596624 +Regulation of ph 5 19 2.291904169543664 0.021911173616028 6.890776699029126 20.859223300970875 1.2151699598837196 0.2373503364294603 2.930458126920059 2.7746402510870145 1.4154672965603718 0.2873526492076106 0.0004302080575038 0.0267403422938185 0.0015259573241502 0.0014919193154812 0.0390821401419673 +Regulation of cellular ph 5 19 2.291904169543664 0.021911173616028 6.885922330097087 20.844660194174757 1.215766922704761 0.2375185297794358 2.9319293283093293 2.765976649626597 1.4143296516981956 0.2875299337708636 0.0003419436993158 0.0239365913087713 0.0012207780133745 0.0010882828125207 0.0302802497568866 +Positive regulation of translation 16 56 2.2861103133973923 0.0222478057863118 14.00485436893204 59.04854368932039 0.2226635785383083 0.671926467094376 6.74788537377648 3.7113801394297217 0.7891314904677239 0.3244977763908461 0.1719598850878803 0.4164957533300368 0.0873897608331362 0.0047916324074489 1.809565812891183e-05 +Protein catabolic process in the vacuole 3 6 2.2839669334956123 0.0223734743451249 2.70873786407767 6.618932038834951 0.8383076008345888 0.2101105309103242 1.6017652153393662 1.88837291272598 1.5176899437744062 0.242508547144668 0.0081505544390514 0.0937235599037543 0.0008717411361388 0.0011814468070448 0.00223229240551 +Lysosomal protein catabolic process 3 6 2.2839669334956123 0.0223734743451249 2.6941747572815533 6.587378640776699 0.838918419522322 0.2080383809566978 1.5899151374262637 1.8707342212441815 1.5239608036504366 0.2420459791980847 0.0066216295693603 0.0847528009868792 0.0006327439593496 0.0007750266814789 0.0013369974246366 +Leukocyte mediated cytotoxicity 4 12 2.277906983154208 0.0227321201403343 4.351941747572815 13.985436893203884 0.4021439577883799 0.5004679143122512 2.4135380942775657 1.8380502421368885 0.9762325275008988 0.3133102965191064 1.0 1.0 0.3593428278464597 0.0989248704147511 0.0707827064406983 +Ion homeostasis 15 97 2.2725243183355115 0.0230548609036687 28.021844660194176 105.69174757281552 0.8349951537384392 0.4299135801564597 10.40966729997928 11.411952082971936 1.4722934854811005 0.3963893325418664 0.0260732468061896 0.0790201295742995 0.0144227917277509 0.0588048327466688 0.3481125312883699 +Negative regulation of proteolysis 8 57 2.269570630974553 0.0232336472441496 13.856796116504857 64.19174757281553 0.1536213676829086 0.6668102754358496 6.420263538974692 5.397287151567414 0.8488834550270293 0.3356070904310471 0.0255378175362461 0.0081893463345359 0.0718109557572085 0.0172083244154783 0.0536138391376844 +Lipid localization 22 66 2.2527557102238225 0.0242745561604167 20.1504854368932 74.27912621359224 1.3966421040883936 0.3001252105784707 7.306180038477171 9.39465098860316 1.572418240819249 0.3627304234720817 0.4503949549496409 0.2954003025990862 0.0012667041047781 0.0009263382354536 0.0004519634212984 +Organic hydroxy compound transport 4 29 2.245479297929539 0.0247373797799723 7.145631067961165 30.32766990291262 0.3121985122058121 0.5028073494895335 3.2773354290298986 4.4061862301676955 1.0194405540894098 0.3270691777029814 0.0388228461283486 0.0161886013519254 0.0039338834845355 0.1233346492847209 0.1594699798608763 +Phospholipid catabolic process 3 9 2.239560542009576 0.0251194667639889 2.8519417475728157 11.6626213592233 -0.4947797705004225 0.2407875191525107 1.5516734206570804 1.908148322767312 1.4202743542297325 0.210826310814772 0.0135775174792461 0.1201219647894398 0.0019068669696529 0.0032545859437725 0.0351238878380088 +Sarcoplasmic reticulum calcium ion transport 1 7 2.232852753219864 0.0255586561390197 1.9563106796116505 7.322815533980583 0.6468881172758483 0.4186906915304785 1.3230715882937036 1.363591714565082 0.9330202288701288 0.2915813242092217 0.116715458993424 1.0 0.0126574737404708 0.0688460117016781 0.2166689846253057 +Glycoside catabolic process 4 6 2.218875351627195 0.026495205829258 2.995145631067961 5.604368932038835 0.914408298188202 0.1915126053981477 1.4021397407455505 0.554137429771367 1.5051386650706404 0.245673751384095 1.0 1.0 0.002465796513642 4.144367191242097e-07 3.274702614006158e-07 +Glycosphingolipid metabolic process 4 8 2.203847387035112 0.0275350787054906 4.764563106796117 9.184466019417476 0.4485135251287195 0.1553285492394019 1.7516723087054535 1.7320372023153958 1.93068386398988 0.2217231968869004 1.0 1.0 0.2732850813359189 0.0078094686864188 0.0203628052401783 +Negative regulation of calcium ion transmembrane transport 3 7 2.202190002485403 0.0276518899655096 2.1067961165048543 7.601941747572815 0.9433101814663925 0.3101119054926485 1.594362771690279 1.170758660555987 1.028728108691548 0.2750664841729511 0.1227903182841607 0.0892490045576324 0.014058804472369 0.0757571260003459 0.0118865434534573 +Nadh dehydrogenase complex assembly 4 22 2.194078157845817 0.0282297912174294 9.266990291262136 26.96359223300971 1.1245271541492263 0.3013677937017552 4.122702675359976 4.029157649894909 1.4460543016521823 0.3224564676521605 0.0069577649248468 0.0026953565990113 0.0173242512102645 0.0483010618227088 0.019705753473984 +Regulation of cell killing 2 7 2.173405576008003 0.0297498055366249 2.844660194174758 8.366504854368932 0.4041102541319114 0.4507662844932221 1.5842506516490529 1.3031494402288128 1.0522249449787806 0.3118972087461248 1.0 1.0 0.2518545844225215 0.0348798008289802 0.1766336232289773 +Negative regulation of immune effector process 6 9 2.1643068565500343 0.0304408068635382 2.5970873786407767 9.104368932038836 0.7327967275062157 0.3846873769388228 1.645172774630188 1.6739814581235892 0.934270881833941 0.2788291164950996 1.0 1.0 0.3076603852203092 0.0630731351339203 0.0020709532532559 +Negative regulation of cell development 5 22 2.158173974011788 0.0309143080825473 4.842233009708738 22.570388349514563 0.359297279383123 0.4985276743183016 2.6202836250687755 3.2526907225500694 0.942582430028218 0.3017948582790589 0.136060560743451 0.0774829110890059 0.228437391614845 0.1916349899499036 0.3056367408200992 +Regulation of mitochondrion organization 13 36 2.1543559407521724 0.0312122689904332 12.08980582524272 45.08252427184466 0.8217268052205459 0.4563186211764868 4.409741308614158 5.146210353910189 1.120993905462196 0.3778427085178187 0.1768634498394247 0.1027744496234552 0.091109134162985 0.0053453327540323 0.0074716409681982 +Positive regulation of peptidyl tyrosine phosphorylation 6 14 2.1525589638870404 0.0313533565446864 4.048543689320389 16.024271844660195 0.1251468305141061 0.6767993816485051 3.113948078635987 2.3922190218352872 0.6632472347251516 0.2742154019855329 1.0 1.0 0.5259644699110895 0.8485799055650284 0.1700618733952761 +Nervous system process 20 84 2.1484240803464623 0.031680081525212 23.060679611650485 100.46844660194176 0.466210961761844 0.5050785047376438 7.1617042179301365 12.55034423055404 1.1784062094355452 0.368401069133876 0.3102977139607078 0.6030924001477935 0.0433288958317329 0.1205828545833994 0.1967404558718577 +Regulation of lipid biosynthetic process 11 26 2.14279795079744 0.0321293259433355 5.211165048543689 26.83009708737864 -0.4437734844517033 0.3480223204908034 2.903224120378468 2.997615069864524 1.2473712283529377 0.2827476345582833 0.1268058928280048 0.0718661948949039 0.2142764757579067 0.3703488858590576 0.1466425101977657 +Regulation of hormone levels 6 57 2.1419348188527527 0.0321987275116524 15.682038834951456 62.25485436893204 0.7754141622249116 0.4638741971732045 6.630568201753413 6.49574922456989 1.111399769110166 0.3798141702267368 0.0164834633268688 0.0214233577780816 0.0048322715185196 0.2702565003392003 0.2560854822741795 +Antigen processing and presentation of peptide antigen 5 10 2.141268867617634 0.032252362194854 4.050970873786408 11.99271844660194 0.9279525789651738 0.3302951212632576 1.9792182503824105 1.8740552023113428 1.0022067378347963 0.2823588878170496 0.2091215881148182 0.1541506060207377 0.2802926639431586 0.0479498850625808 0.0053527619374205 +Regulation of glucose import 5 9 2.1406190726624184 0.0323047694494573 2.7427184466019416 9.031553398058252 0.4006150731161149 0.4855839033057929 1.6030372835271705 2.017273588927774 0.9030919727667402 0.2937882051217688 1.0 1.0 0.2872333566147377 0.051542815486873 0.0257423149537502 +Organic acid transmembrane transport 8 27 2.137197761309845 0.0325819100542115 12.37621359223301 29.983009708737864 1.9038035525846064 0.1759244630123113 6.520447095353999 3.550222565141749 1.416714921004232 0.2641413901650407 0.1044145484518049 0.326192706464958 0.0415809882988902 0.0031061282245647 0.0151062022161933 +Cellular iron ion homeostasis 3 12 2.1358282456194044 0.0326934159497893 3.66504854368932 13.521844660194176 0.8677978780626455 0.311898632686956 1.8823249793116483 1.671290558583202 1.0630934740559084 0.2702936919112085 0.0292392559415296 0.1747599807978781 0.0061250241039257 0.0140312853386763 0.1190174178925116 +Negative regulation of peptidase activity 4 34 2.1337759922158592 0.032861122028859 8.29368932038835 36.58252427184466 -0.063782348021029 0.6095822183297694 4.3448059583944065 3.473266199713329 0.8447550419032326 0.3073217557628559 0.0296536551905682 0.0121763996061447 0.0681614338573012 0.0880352084429092 0.1980954333562903 +Positive regulation of mrna splicing via spliceosome 3 17 2.1321312555939227 0.0329960578152219 5.868932038834951 16.20873786407767 0.0871896031470175 0.5437393324787213 3.2098612959239534 0.8533892220402522 1.0533370630695786 0.3337140371767123 1.0 1.0 0.1596960736798767 0.0688460117016781 0.0097510399506001 +Sphingolipid biosynthetic process 3 14 2.1291057042222463 0.033245515941213 6.543689320388349 16.33252427184466 1.3108583596388097 0.2293036031089034 3.2058099533310203 2.4273143169149307 1.5209865792019848 0.2861850290041513 0.3347698423652137 0.2523879312119707 0.1100932826860655 0.053649406266927 0.3214758618506753 +Regulation of peptidyl tyrosine phosphorylation 10 23 2.128245788138862 0.0333167102830724 6.378640776699029 27.87135922330097 0.1802199323220069 0.6349333342581757 3.0857219100090787 4.315860914587658 0.7372095149693096 0.2961615496176262 1.0 1.0 0.6943670866160305 0.5679451642648087 0.1383697049953699 +Regulation of calcium ion transport 6 31 2.1281259276054194 0.0333266441515027 6.822815533980583 30.97087378640777 0.2562664278960043 0.6157218075304739 3.448675535122841 4.183198735857738 0.7878128488294773 0.3113076406394647 0.1719598850878803 0.0996898015200429 0.0873897608331362 0.1233346492847209 0.1594699798608763 +Gliogenesis 19 48 2.124532334095949 0.0336256552567915 10.57766990291262 53.11407766990291 0.3128888864166735 0.6283481078716698 4.440686381801957 5.34345583548812 0.8423545321673526 0.3276548637936928 0.3134966362325414 0.1937386641817528 0.074375194998397 0.1044344220246968 0.0063943222071951 +Regulation of glucose transmembrane transport 5 10 2.120273963426892 0.0339829480613451 3.2985436893203883 11.701456310679612 0.1763889197217673 0.5366127906142713 1.8183791501026776 2.572388451454916 0.87346202075329 0.2871327431050578 1.0 1.0 0.3404254693467198 0.0846608217542885 0.0558327828623465 +Membrane lipid catabolic process 5 10 2.118686014947301 0.0341170110158928 5.854368932038835 11.361650485436892 0.500872843713425 0.1363587272813367 1.9603237645724247 0.9867004907377388 2.113024793917032 0.2289617793743788 0.1288239900669949 1.0 0.0155240337321844 0.0011814468070448 0.0002747300414667 +Ceramide biosynthetic process 2 8 2.118166202642493 0.0341609943983667 4.033980582524272 10.24757281553398 1.048715387316577 0.2344614502118888 2.237979905601341 2.0281678881596505 1.4071730245015133 0.2685344998940062 0.2145694811298145 0.1583124314184509 0.0443091130960601 0.051542815486873 0.2403376761227438 +Genitalia development 1 5 2.115983795524939 0.0343461857810769 0.7305825242718447 5.084951456310679 0.6929022329405563 0.4417126641011115 1.037049890892166 1.004874888397969 0.8649138953774324 0.292043177076853 0.1525522796012576 0.1114073342812727 0.0219975904219434 0.1131762501747812 0.32624452618512 +Ceramide catabolic process 3 6 2.1113208373458017 0.0347447441900354 3.8592233009708736 6.531553398058253 0.1286784152295923 0.1423502941444668 1.429436503356119 0.7012295128365029 2.0219843992394857 0.2259194528389771 1.0 1.0 0.1094892401774078 0.0025975272437437 0.0019884945269669 +Antigen processing and presentation of endogenous antigen 4 6 2.109702895485535 0.0348839549465693 2.6529126213592233 6.463592233009709 1.0779744166035472 0.2832041157954688 1.4492771087670022 1.3990755299770097 1.00991421519493 0.2818848392729987 1.0 1.0 1.0 0.0495157384890535 0.0005289198821125 +Antigen processing and presentation of endogenous peptide antigen 4 6 2.109702895485535 0.0348839549465693 2.638349514563106 6.390776699029126 1.097011591019633 0.2766562869747734 1.460743657586565 1.3760123823390067 1.0015631459591094 0.2785574288267012 1.0 1.0 1.0 0.0435926191526008 0.0003671727016274 +Vacuole organization 7 44 2.098389461196128 0.0358707554917006 14.220873786407768 51.74514563106796 0.8524122478550634 0.3147425083910056 5.370022076358251 7.439112114793103 1.7567175511320523 0.3563110134355993 0.0217029042495365 0.1760534030430948 0.0007129128227558 0.0127416531618932 0.2208062336115092 +Amyloid precursor protein metabolic process 7 16 2.095166521212039 0.0361561922252262 5.91747572815534 20.04368932038835 1.2306110398413417 0.2828388345239639 2.574706211328507 3.0661056512526157 1.0127867956133585 0.2841981221806073 0.3160781753191097 0.237457799625543 0.4129317333780675 0.0432632841258681 0.0047453897441578 +Carboxylic acid transport 7 32 2.085228208741641 0.0370485904855724 12.351941747572816 33.69417475728155 1.517249458545343 0.2522623764771551 6.23371050940395 4.11174791553619 1.419876490432768 0.3135855212793009 0.162226320569615 0.4047844567784328 0.2676422850845579 0.1098174049188518 0.0686472570530836 +Sterol metabolic process 14 34 2.081860788300815 0.0373551873286213 11.932038834951456 38.44660194174757 1.1656335789111734 0.2523239777622673 4.346099994655023 4.0619669904912925 1.6676089351046874 0.3062687621764124 0.0205028898701518 0.0650462755169659 0.00132313066272 0.000199462708587 0.0002122388464955 +Glycerophospholipid catabolic process 1 6 2.080947234030614 0.0374387360722461 2.216019417475728 7.563106796116505 0.8419758607208171 0.2558936783676348 1.405411068501889 1.391164232085279 1.2384126210044872 0.2497846504551273 0.1044410678243998 0.0756950383436983 0.0100519320580488 0.0557098434243155 0.1807018090276839 +Glycerolipid catabolic process 1 6 2.080947234030614 0.0374387360722461 2.313106796116505 9.682038834951456 -0.6906699682904549 0.2344337110397997 1.480134820103212 2.05940129824901 1.3437574149282263 0.2068175776304703 0.1869550577816913 0.1373006943976843 0.0334071197556988 0.1627514901813832 0.4315495391205481 +Cellular hormone metabolic process 2 15 2.0800793875858066 0.0375182518707861 5.441747572815534 17.32766990291262 0.9908884218524354 0.2940959275691314 2.8170777488519256 1.7185203072340225 1.2515909253444888 0.3031653223897966 0.0477446044332599 0.0257915242502586 0.0128487417044244 0.124643595331372 0.4533341301651876 +Negative regulation of gliogenesis 1 5 2.075299938246154 0.0379587451792609 1.3470873786407769 5.104368932038835 0.7908721225635217 0.3008340423028514 0.9967988871839628 1.1559387979758486 1.13650278668033 0.2567959459302846 0.0098222160934675 0.0051137089586154 0.018640880521655 0.097689242801984 0.2898287915273368 +Response to molecule of bacterial origin 10 34 2.0664558577657592 0.0387854563400453 7.725728155339806 38.39320388349515 0.085181781384209 0.6819865007463539 3.6189922702755353 4.532059737391585 0.6781162635899375 0.2855879587135924 0.2472345290339421 0.1484013327004848 0.1494094536407435 0.4329341520448383 0.3625410698306791 +Antigen processing and presentation of peptide antigen via mhc class i 5 9 2.0563046572221144 0.0397531596797777 3.5533980582524274 10.33980582524272 0.9522781165124746 0.321717188118692 1.7458864571217907 1.7766194475253527 0.972074824811495 0.2764762653101907 0.1407688702116439 0.1026081339138497 0.191600110602388 0.0152248647419399 0.0004867641084232 +Crd mediated mrna stabilization 4 9 2.0524135194459623 0.0401294917534909 3.20873786407767 8.672330097087379 0.342620078434644 0.5402296309994439 1.975608879775515 0.4994282243026395 0.8747796830448701 0.31559390711261 1.0 1.0 1.0 0.0186627473263165 2.8311070051942505e-05 +Negative regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay 4 9 2.0524135194459623 0.0401294917534909 3.2305825242718447 8.737864077669903 0.3383340983010549 0.5432346157858564 2.00913850312594 0.5653620722928415 0.8709422947456378 0.3151834351252267 1.0 1.0 1.0 0.032628233248221 0.0001575214550341 +Negative regulation of nervous system development 5 19 2.051814524433531 0.0401876912083161 4.225728155339806 17.99514563106796 0.4680685636974716 0.419713233745777 2.1977522064718618 2.960086545598349 1.0442754970945465 0.2873726818408866 0.1000804307877045 0.0559003563721154 0.1724639155075248 0.1191496891129861 0.1772555379782259 +Positive regulation of cell killing 2 6 2.049938064501408 0.0403704751111084 2.344660194174758 6.594660194174757 0.4156629456801037 0.4127481983530973 1.3626949423444794 0.9467730739010484 1.1172564974004802 0.3098028662961327 1.0 1.0 0.1837383274168749 0.0133829456596615 0.0790607116166092 +Regulation of leukocyte mediated cytotoxicity 2 6 2.049938064501408 0.0403704751111084 2.5825242718446604 7.334951456310679 0.4511695306521209 0.4227043221453989 1.4499700153890709 1.2995300672557608 1.082342679990832 0.3098039206468536 1.0 1.0 0.2070995190727305 0.0193169154759243 0.1083207684216986 +Sphingoid metabolic process 2 5 2.048534440548824 0.0405076610205741 2.337378640776699 5.174757281553398 0.8258730035764346 0.2192038420096116 1.196784089801513 0.5941001920342514 1.4738240163378542 0.2563928956394505 1.0 1.0 0.0921025797166938 0.0014684283121974 0.0105668672564949 +Glycoside metabolic process 4 9 2.0479726129122504 0.0405626829895202 3.283980582524272 8.611650485436893 0.5062828222010527 0.3204164092287125 1.4990079825210394 0.6824144700308834 1.298018080705215 0.2868097664691992 1.0 1.0 0.0088504827764808 1.934192081629664e-05 4.367834065541858e-05 +Response to axon injury 3 13 2.0456333442428005 0.0407924582684307 3.4223300970873787 15.0873786407767 0.4784356131295292 0.5286211208988147 2.0530078354914556 2.3631754024711653 0.7880827580202387 0.2904779371725667 0.0444222413026605 0.0239365913087713 0.0803922289273931 0.1140816659952819 0.2132278663521486 +Regulation of mrna catabolic process 21 74 2.044739257413052 0.0408805710978994 20.597087378640776 75.27427184466019 0.0974333299483354 0.6614725434945096 7.572484122695899 6.229043951318669 0.82192672305461 0.3208658873149163 0.2523325728656685 1.0 0.1539610702624851 0.0005991930223406 1.0762089589049546e-06 +Regulation of alternative mrna splicing via spliceosome 11 31 2.0437085939922195 0.0409823437099028 10.609223300970871 30.575242718446603 0.1468114472042654 0.5502297177540902 5.108075880658377 2.6128265930148187 1.194088433027589 0.3536418549118582 0.287065986663278 1.0 0.3777229935777695 0.0300192966842153 2.672510894072328e-06 +Natural killer cell mediated immunity 3 8 2.0359026571074508 0.0417601309678223 3.0266990291262137 9.79611650485437 0.3581391067116419 0.5074304089326694 1.9300298746867943 1.587935236879548 0.9456543485669218 0.3100992296137194 1.0 1.0 1.0 0.1713585638073601 0.0612536211646263 +Neuron projection regeneration 3 10 2.030936478806527 0.0422614387102331 2.3058252427184467 9.79611650485437 0.887202443720293 0.3987106095324453 1.3505356896696743 1.5461145996848544 0.8042022398095918 0.2932545495700766 0.0238932255598992 0.012648542478749 0.0443091130960601 0.051542815486873 0.087821349317486 +Regulation of nitric oxide metabolic process 2 10 2.028412295878539 0.0425181862104959 2.783980582524272 10.701456310679612 0.1430441353915724 0.5171013303945987 1.722054451404933 1.369110623206423 0.8984736114957514 0.280454644640389 0.1925534392463908 0.141543756104335 0.2590666885683055 0.0379489226270714 0.1889957663081205 +Response to thyroid hormone 1 6 2.022286012614773 0.0431468128018317 1.7087378640776698 6.662621359223301 0.3704077449468085 0.4940041388056373 1.616847393661985 1.1235609662945203 0.8929316466794897 0.2904037257022112 0.1227903182841607 0.0892490045576324 0.014058804472369 0.0757571260003459 0.2348875720984273 +Pinocytosis 4 8 2.0221403762790704 0.0431618518226497 1.8713592233009708 7.33252427184466 0.5840579949486326 0.3745201042297812 1.4960968950914608 1.2320991783672317 1.0871891924456092 0.2933375341256155 0.116715458993424 1.0 0.1596960736798767 0.0688460117016781 0.0013369974246366 +Lipoprotein biosynthetic process 1 9 2.013811365163025 0.0440293420398691 3.837378640776699 12.817961165048544 0.5159177916871569 0.4870101230655305 2.4216380804227313 3.0215034704254133 0.9442820469649724 0.3192432047465013 1.0 1.0 0.4724360815693985 0.4755559518983523 0.8373165589367211 +Negative regulation of hydrolase activity 11 55 2.008355741889972 0.0446055024099774 13.71359223300971 61.55582524271845 -0.0365477234421551 0.6686475173700427 6.008126350326953 6.2538756952931465 0.8021313488618124 0.3189731412355006 0.1128021242300304 0.0511928730161325 0.2266894976786812 0.3961695333364228 0.0385754170357189 +Immune response regulating cell surface receptor signaling pathway 8 25 2.0067005487561507 0.0447815575680889 6.776699029126213 27.74271844660194 0.136139815526792 0.6569804635275405 4.022224759534535 4.3512993694161155 0.7512753157901814 0.2976989793111175 0.5706643912870694 0.453019277017924 0.6943670866160305 0.5679451642648087 0.1383697049953699 +Cellular carbohydrate catabolic process 5 17 2.002963311017323 0.0451812266525866 4.094660194174757 17.519417475728154 0.0720112229026999 0.5230835350302091 2.73830622849908 1.2452284270055651 0.9511421553520558 0.2982026173853891 1.0 1.0 0.031373049189738 0.0319451393300601 0.0023211498250519 +Diol biosynthetic process 2 7 1.99823072388866 0.0456916520699755 2.5315533980582523 7.747572815533981 0.934609081792458 0.2730932800244148 1.324333323602112 0.9054146354978068 1.183401939154622 0.2688651038177358 1.0 1.0 0.1180585699575878 0.0033170374819039 0.0225979674873623 +Diol metabolic process 2 7 1.99823072388866 0.0456916520699755 2.5315533980582523 7.747572815533981 0.934609081792458 0.2730932800244148 1.324333323602112 0.9054146354978068 1.183401939154622 0.2688651038177358 1.0 1.0 0.1432798584585485 0.0061570039439817 0.0397387250697101 +Neuron apoptotic process 16 42 1.9950442819211676 0.0460380504341926 11.191747572815531 49.65533980582524 0.9007291731588002 0.4299023129629146 4.0102574614548505 4.518854312987721 0.9862249081516458 0.3541854094791909 0.6419333636313859 1.0 0.1702274141564555 0.1480406608198908 0.1052154351710089 +Dna modification 8 27 1.98709129641972 0.0469122805758801 7.449029126213592 29.95631067961165 0.0525974592283249 0.623813202387164 4.976627316341219 4.039613792529995 0.8319095595259771 0.3052628102732242 0.1000804307877045 0.3194831905047319 0.1724639155075248 0.1191496891129861 0.0129291666059707 +Negative regulation of cell population proliferation 21 84 1.983754545106775 0.0472832096527364 19.383495145631063 97.08252427184466 0.1581356625225672 0.7238624266901581 7.86528068228601 11.547200956886966 0.6889214696860141 0.3091925248352111 0.5235358204012034 0.3139745775617462 0.0908732427478486 0.2621065026651326 0.6701020925267132 +Enzyme linked receptor protein signaling pathway 32 96 1.9825689853944528 0.0474155945805392 25.24271844660194 117.68932038834951 0.1053848292396163 0.7149684279491084 9.284046259048107 15.168490031291515 0.7848849412953816 0.3313693252810506 0.7014884837767816 0.4742040015497096 0.7447427836145701 0.9397114018785148 0.5549929107541557 +Cellular monovalent inorganic cation homeostasis 5 24 1.9802786358764928 0.0476722280405061 8.191747572815533 25.12378640776699 1.1978511848260835 0.2636491484517694 3.558748260132903 2.9783551257949803 1.4212259473978417 0.3021468238591936 0.0007916815573662 0.0358926009784828 0.0027541417385927 0.0033989983353886 0.0744808849197366 +Determination of adult lifespan 1 6 1.9788659766234569 0.0478310978143796 1.4684466019417477 6.878640776699029 0.9172678211727472 0.3356532972350567 1.327993783820954 0.8617154358126836 0.9778379941999832 0.290947936133699 0.0919985780100544 1.0 0.0077184558590264 0.0435926191526008 0.1457988469723397 +Protein localization to cytoskeleton 10 15 1.9763783672446744 0.0481119397796356 6.004854368932039 18.62621359223301 -0.2034314636470449 0.6523913962354377 2.980515321338466 3.5164098296843456 0.6969429501467459 0.2740820639430165 1.0 1.0 1.0 0.7462567628712866 0.5157725074249294 +Neutral lipid metabolic process 2 9 1.9723898862124056 0.0485651155082582 3.7645631067961167 14.638349514563108 -0.2959545341177167 0.2756576316525815 2.469308018590983 2.835760748630011 1.4124950075268554 0.2284226385878861 0.3706553264366192 0.2813938178053637 0.0264876267470493 0.2193268794643932 0.4107237856119327 +T cell mediated cytotoxicity 2 6 1.9651594259021847 0.049395788386457 2.3155339805825244 6.371359223300971 0.523676216262352 0.4362981633701682 1.467264629016786 1.0863026706760155 1.002848585470677 0.3105377797682886 1.0 1.0 0.1837383274168749 0.0133829456596615 0.0790607116166092 +Regulation of mitochondrial gene expression 1 9 1.9644225027144653 0.0494811153587182 2.594660194174758 11.4247572815534 0.8803116051858394 0.3443222138925089 2.2226265034531534 1.9350293365530056 0.991093358800792 0.2980671372776958 0.1699293347786211 0.1244478155008913 0.2297987482657219 0.1374615323876937 0.3798345415961738 +Glycolipid catabolic process 4 6 1.9615640870473892 0.0498132568539664 3.6310679611650487 6.451456310679611 0.1059933679561382 0.1697430158083476 1.434595381284437 0.7664524352299261 1.9023109688101565 0.2365791262889882 1.0 1.0 0.1094892401774078 0.0025975272437437 0.0001575214550341 +Dna methylation 3 16 1.960560815516324 0.0499302771357117 4.283980582524272 18.48058252427185 0.3368664558597276 0.5549461558551047 3.1251307824457446 3.053266856273282 0.885226763878063 0.3084732602561963 0.0380538317051311 0.1988423464133734 0.0693457394610891 0.0227330174276438 0.0655768501043339 diff --git a/msigdb_gobp/metrics.json b/msigdb_gobp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..81495b1bb90fc7e50f10b401d50096f7ecbe8434 --- /dev/null +++ b/msigdb_gobp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2812, + "annotations_size": 6337, + "title": "Average number of proteins per term", + "value": 17.34448477197412 +} \ No newline at end of file diff --git a/msigdb_gobp/paths.json b/msigdb_gobp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..bfc048718de24bca61c453c106ce5852551875fb --- /dev/null +++ b/msigdb_gobp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gobp/fragment/C428/C428_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gobp/result.tsv b/msigdb_gobp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..80e5a9c82728ce833bc1b4bd8d7b1dfbf261b8b8 --- /dev/null +++ b/msigdb_gobp/result.tsv @@ -0,0 +1,1976 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Sphingolipid metabolic process 0.6935016645473354 3.2765927785689777 0.0010506778657519 0.9987209604961562 0.2732340966696277 25 P16278,P50897,P07602,P06280,O15270,Q06136,Q8NCC3,P06865,P04062,Q96G23 10 +Membrane lipid metabolic process 0.660324605972221 3.23367140447041 0.0012220997700467 0.9995689051165292 0.2732340966696277 32 P16278,P50897,P07602,P06280,O15270,Q06136,Q8NCC3,P06865,P04062,Q8NBX0,Q96G23 11 +Hormone metabolic process 0.6700152347971177 3.1854220134403133 0.0014454305605768 0.9998954996041732 0.2732340966696277 28 P30536,Q9HB40,P42892,O75844,P07858 5 +Entry into host 0.6503721664838432 3.0481796177481946 0.0023023226778393 0.999999546667447 0.2732340966696277 28 O00505,Q8WTV0,Q9BTY2,O15118,Q14108,P19474,P07858 7 +Anion transport 0.5279541370760317 2.9778402310126793 0.0029028726033752 0.999999990015734 0.2732340966696277 62 P30536,P07602,P14174,P21796,Q9C0H2,Q9Y619,P45880,Q9H2D1,P08183,Q9UHG3,P53985,Q9UBX3,Q9Y4C2,Q7L0J3 14 +Inorganic anion transport 0.7290826479074832 2.9696075648831393 0.002981804000101 0.9999999939543068 0.2732340966696277 20 P30536,P21796,Q9C0H2,P45880,Q9UHG3,Q9UBX3 6 +Protein import 0.4819213936600148 2.8644574605379773 0.0041772425783477 0.9999999999969826 0.2732340966696277 80 P55735,Q9NS69,Q99567,Q99595,O60830,Q9UKG1,O14925,P40855,O75312,P57740,Q9NW64,Q16539,O00505,Q9Y512,Q92973,O00629,P52294,O14737,O60684,Q9BW27,Q13501,Q06481 22 +Mitochondrial respiratory chain complex assembly 0.6156455992887394 2.8479880737775938 0.0043996573286404 0.9999999999992674 0.2732340966696277 30 Q9Y512,Q96CU9,O43676,Q9H061,O75306,P47985,Q6DKK2,Q9Y2R0 8 +Negative regulation of cytokine production 0.6283611592242303 2.833112382941408 0.0046097176414612 0.9999999999998076 0.2732340966696277 25 P30536,Q8WXW3,O43823,P09601,Q06481,P04083,P04062,P31483 8 +Regeneration 0.6130591253344952 2.8041642541099097 0.0050447197901761 0.999999999999988 0.2732340966696277 29 P30536,P11717,P52294,P09601,P04083,P00374,Q96G23 7 +Protein insertion into membrane 0.6690778358312263 2.7876599353206566 0.0053090241103046 0.9999999999999978 0.2752958799664353 22 O43765,P30419,Q9Y512,Q9NS69,P46379,O14737 6 +Regulation of blood pressure 0.7390918164741369 2.781035695659064 0.0054185778816058 0.9999999999999988 0.2752958799664353 17 Q9HB40,Q9Y5X3,Q9NZ08,P42785,P09601,P42892,Q6P179,Q9UIQ6 8 +Regulation of autophagy 0.471826299333504 2.7757831487195905 0.0055068924677474 0.9999999999999992 0.2752958799664353 81 P30536,P10619,P07602,Q07820,Q9Y487,Q93050,P21796,O15270,P09601,O15118,Q8NHS3,P19474,P04062,O75844,P36543 15 +Anion transmembrane transport 0.5781411483479606 2.769725211581858 0.0056103602847246 0.9999999999999996 0.2752958799664353 38 P21796,Q9Y619,P45880,Q9H2D1,Q9UHG3,P53985,Q9UBX3,Q9Y4C2 8 +Protein targeting 0.4419315682401062 2.764569598008565 0.0056997946542147 0.9999999999999998 0.2752958799664353 99 P30536,Q9NS69,Q99595,O60830,Q5JRX3,Q16543,Q9Y512,P46379,O14737,Q15629,Q9Y4C2,O43765,O60725,Q9UHB9,Q14108,P31751,O14964,Q8N4H5,P43307,Q9Y2T2 20 +Protein localization to mitochondrion 0.5164921575794854 2.7442885641362023 0.0060642205348688 1.0 0.2752958799664353 54 P30536,P30419,Q9Y512,Q9NS69,Q99595,O60830,Q8N4H5,O14737,Q5JRX3 9 +Macromolecule catabolic process 0.3417855713102691 2.7387443394091036 0.0061674312669079 1.0 0.2752958799664353 386 Q5VTR2,Q9Y3I1,O75477,O00231,P49721,Q8NHS3,O75503,Q9UIQ6,Q14258,Q9UJX2,O60502,Q9UBS8,P07858,Q16539,O95831,P28072,P46379,Q9UHG3,O75844,Q13042,P51114,Q8N511,Q92804,O76024,O00462,P10619,P50897,Q16850,P28074,P61289,Q9NVV4,Q92615,O15514,P54802,Q9Y2L1,Q9Y263,P04062,Q9HCE1,Q9NUJ1,Q14011,Q8IYB8,O14773,P20618,P28070,P60900,Q9H2J4,P16989,P51116,P35637,P08236,P16278,O00584,Q969T7,Q92945,O43765,O60506,Q92783,Q99436,Q96K76,Q16740,P67809,Q9Y679,P98175,O14964,Q15369,Q9H074,Q96B26,Q13310,Q08J23,Q9UPU5,Q8TEY7,P25788,Q8NF37,P10253,Q86VM9,P49720,Q8TCT9,Q12972,Q6PGP7,Q99729,Q9UJX3,Q14103,Q06787,O75832,Q9H000,Q8N3C0,P35573,Q07954,Q96C86,Q96RU2,Q5RKV6,P62136,P08670,P04066,O75312,Q9C0B1,Q9BRP8,P11940,Q9Y5X3,Q92990,Q14671,Q96KB5,Q13501,Q9UJX4,Q9UJX6,P40818,Q9UL46,Q8IXJ6,P42345 109 +Lytic vacuole organization 0.6905351850442499 2.7361099095113777 0.0062170257189866 1.0 0.2752958799664353 20 P50897,O14773,P11117,Q8NHS3,O75503,P54802,Q14108,P04062,Q8N511 9 +Negative regulation of response to external stimulus 0.5658222129584017 2.6901194797231427 0.0071426441121884 1.0 0.2846725518172217 39 Q9UMX5,Q9H000,P14174,P01889,P80303,O14936,P28070,P19474,P04062,Q96G23,P04439 11 +Lipoprotein metabolic process 0.7505403548672945 2.659946360425876 0.0078153096911037 1.0 0.3003908396590837 14 P30419,P50897,Q9NUJ1,P04062 4 +Ceramide metabolic process 0.725736389849168 2.6392010079184773 0.0083101691342348 1.0 0.3003908396590837 16 O15270,P06280,Q8NCC3,P06865,P04062,Q96G23 6 +Transmembrane transport 0.4549544705255465 2.632416737118101 0.0084779800662753 1.0 0.3003908396590837 187 Q9NS69,Q99595,O60830,Q70HW3,P21796,Q9C0H2,P45880,Q96ES6,Q8NHS3,P36543,P53985,O75964,Q8WTV0,Q9BZF1,Q8IXU6,P62942,Q5SR56,Q15629,Q9UHG3,O75844,Q6P4Q7,Q9UBX3,Q9H2D1,Q9Y4C2,O43865,P78417,Q14847,O43772,Q9Y619,P08183,P04062,Q06124,Q8NE01,Q9HD20,Q07820,P42858,P31751,Q06481,P47985,Q7L0J3 40 +Negative regulation of multicellular organismal process 0.4290916705792186 2.6288609515374817 0.008567138300032 1.0 0.3003908396590837 94 P30536,Q9NQC3,P15260,P16989,P04083,Q9UIQ6,Q96G23,Q96FV9,O43823,Q92945,P31483,Q8WXW3,Q16850,Q8N0X7,Q4VCS5,P09601,P04062,Q06124,O14964,Q06481,P35080,Q9UBS4 22 +Nls bearing protein import into nucleus 0.8630359170475346 2.621199546181102 0.0087620958541194 1.0 0.3003908396590837 9 O00505,O00629,P52294 3 +Chloride transport 0.8318119583356635 2.614915952606417 0.0089249414373866 1.0 0.3003908396590837 10 P30536,Q9C0H2,Q9UHG3 3 +Mitochondrial transport 0.4668116876796711 2.603516146943274 0.0092272921023919 1.0 0.3003908396590837 77 P30536,P30419,Q9Y512,Q9NS69,Q99595,O60830,O43772,P45880,O14737,O75964,Q5JRX3,Q9UBX3 12 +Ph reduction 0.7793154835559252 2.6002253124893464 0.0093162570147455 1.0 0.3003908396590837 12 Q9Y487,P50897,O75503,Q8N511 4 +Vacuolar acidification 0.8582279134657962 2.5998414171499395 0.0093266849876263 1.0 0.3003908396590837 9 Q9Y487,P50897,O75503,Q8N511 4 +Rna stabilization 0.5855793777909776 2.5799781144228406 0.0098806576843526 1.0 0.3003908396590837 28 Q14103,Q16539,O60506,Q9H074,P11940,P67809,P98175,P16989,Q92615,P35637,Q08J23,Q14011,Q92804 13 +Negative regulation of mrna catabolic process 0.5850427946092104 2.557200958321535 0.0105518239723567 1.0 0.3003908396590837 27 Q14103,P67809,O60506,Q9H074,Q06787,P98175,P16989,P35637,Q99729,Q14011,Q92804 11 +Regulation of response to external stimulus 0.4338083009424562 2.537856411290007 0.0111533735137678 1.0 0.3003908396590837 117 P14174,Q9UKG1,P04083,P43243,Q96G23,P04439,Q16543,Q16539,Q9UMX5,P01889,Q9NZ08,Q14671,O75844,P80303,Q53EL6,P10586,O75179,Q9NUD5,P58107,Q9UNH7,P04062,Q96ST3,Q9NUQ9,Q96KB5,Q06124,P30419,O00429,Q9H000,Q8IXJ6,Q02750,Q99496,Q06481,P28070,P04792,O94992,P19474,Q9BVA1,P60900,O14936,O43657,Q96PK6 41 +Peptide catabolic process 0.809554751742981 2.5112095225708795 0.0120318260993763 1.0 0.3003908396590837 10 Q99829,O14773,P55786,P42892,Q6P179,Q9UIQ6,P09960 7 +Protein import into mitochondrial matrix 0.8370746340313348 2.50520592970539 0.012238011748993 1.0 0.3003908396590837 9 Q99595 1 +Regulation of pattern recognition receptor signaling pathway 0.7019214485972894 2.5051099279999143 0.0122413340794509 1.0 0.3003908396590837 16 O75179,Q9NQC3,Q9NUD5,Q06481,Q9UKG1,Q9NPR9,O43657 7 +Detection of stimulus 0.7599853963907293 2.502958478140233 0.0123159992156691 1.0 0.3003908396590837 12 P30536,P30419,Q8WTV0,P01889,P04439 5 +Peptidyl tyrosine modification 0.5661434645591512 2.499455331912581 0.0124384378683306 1.0 0.3008487815710358 31 Q9H2J4,Q8WXW3,P45985,Q13432,Q92769,P14174,P30153,Q02750,Q96KB5,O95684,Q9H223,Q06124 12 +Cytokine production 0.4246527473445371 2.4611163937764764 0.0138505424241985 1.0 0.3052740603114079 89 P30536,P15260,P14174,Q9UKG1,P04083,P04439,Q01650,P01889,Q92990,O43823,P31483,O60684,Q53EL6,Q8WXW3,Q8IV08,Q9NUD5,P09601,P04062,Q9BYW2,Q9NUQ9,Q06124,Q92769,Q06481,P19474,Q99943,Q9Y624 26 +Cellular response to biotic stimulus 0.5579196155905901 2.460797110987806 0.0138628736138304 1.0 0.3052740603114079 32 P30536,Q16539,O76024,Q8WTV0,Q8IXJ6,P14174,P08670,O43823,O75844,Q9NUQ9,Q53EL6 11 +Circulatory system process 0.4740657707814877 2.454233312519845 0.0141185345081569 1.0 0.3060154203030362 65 Q01650,Q9HB40,Q07954,P78417,Q9Y5X3,Q9NZ08,P42785,P09601,P10253,P08183,P42892,Q6P179,O75844,Q9UIQ6,P53985 15 +Protein targeting to mitochondrion 0.5239364470079034 2.452260149182054 0.0141961985982326 1.0 0.3060154203030362 44 P30536,Q9Y512,Q9NS69,Q99595,O60830,O14737,Q5JRX3 7 +Establishment of protein localization to mitochondrial membrane 0.7475975427283365 2.4400284914508648 0.0146861035822629 1.0 0.3091880398519032 12 P30419,Q9Y512,Q9NS69 3 +Protein transmembrane transport 0.6268937109952508 2.421350446166394 0.0154629622271973 1.0 0.3212747266680313 21 Q9NS69,Q07820,P31751,Q99595,O60830 5 +Liposaccharide metabolic process 0.6934543567397423 2.4008463045900794 0.0163572051352991 1.0 0.3252301900323068 15 P16278,P06280,P06865,P04062,Q8NBX0,P17900 6 +Membrane lipid biosynthetic process 0.6359775002059487 2.394667609602732 0.0166354382627547 1.0 0.3252301900323068 20 Q8NBX0,Q06136,Q96G23,P04062 4 +Positive regulation of cellular amide metabolic process 0.4744319788125156 2.3862053460327632 0.0170232427889578 1.0 0.3253079399666301 58 Q14103,P67809,O60506,Q9H074,Q06787,P15260,Q9Y2R0,P16989,P51116,P08670,Q71RC2,Q14011,Q567V2,P51114,P98179,Q07666,Q9BRP8 17 +Mitochondrion organization 0.4343065053109009 2.376459838435637 0.0174796641278947 1.0 0.3257900928778491 155 P30536,Q96CU9,Q9NS69,O75153,Q99595,O60830,P21796,P45880,Q5JRX3,Q16543,Q8N2A8,Q9Y512,O43676,Q96A26,Q9H061,O14737,P04062,Q9NUQ9,P30419,P42858,Q8N4H5,Q9Y6C9,O75306,P47985,Q6DKK2,Q9Y6M9,Q9Y2R0 27 +Secondary alcohol metabolic process 0.5304996918475826 2.3740323402976236 0.0175950093113299 1.0 0.3269782228911962 38 Q8WTV0,O75874,Q16850,Q15392,P48449,O15118,P04062,Q15800,P48735,Q9BQE5 10 +Cellular response to molecule of bacterial origin 0.5638406779595234 2.3708659149443796 0.0177464678221039 1.0 0.3288285572768215 25 P30536,Q16539,Q8WTV0,P14174,P08670,O43823,Q8IXJ6,Q9NUQ9,Q53EL6 9 +Regulation of immune response 0.4191293895386434 2.3651845102989695 0.018021090182291 1.0 0.3318786426036388 112 Q9NQC3,Q5RKV6,Q9UKG1,P04083,O96028,P43243,Q14258,P04439,Q16543,Q16539,Q96FZ2,P01889,Q96FV9,Q9NZ08,P46379,P62942,Q14671,Q9NPR9,P46109,Q07666,O75179,P45985,Q9NUD5,P09601,Q96ST3,Q9NUQ9,P17931,Q06124,Q9H000,Q96IZ0,Q5KU26,Q06481,P28070,O94992,P19474,O43657,Q96PK6 37 +Response to food 0.9736631765442284 2.3641575944130504 0.0180711235211321 1.0 0.3318786426036388 5 P53985,Q9UMX5 2 +Iron ion homeostasis 0.6741748627252827 2.3462500253692897 0.0189633818187873 1.0 0.3363147895815078 16 Q9Y487,Q8N511,P30519,P09601 4 +Regulation of gliogenesis 0.7440615628677039 2.3342871503433544 0.0195806911194347 1.0 0.3427702752040272 11 P30536 1 +Insulin receptor signaling pathway 0.5714165390226233 2.32283505121247 0.0201880153099429 1.0 0.3492677322609318 24 P31751,Q9Y5X3,Q9BZF1,Q9UKG1,P43490,Q9HCD5,Q9UQB8,Q92572,Q06124 9 +Protein transmembrane import into intracellular organelle 0.7228147360608195 2.3127240869894483 0.0207378138311291 1.0 0.3492677322609318 12 Q99595 1 +Regulation of rna splicing 0.4206356893486635 2.299924577637647 0.0214524933981992 1.0 0.354291463254649 86 P51116,P52597,P38159,P35637,O75312,P22626,P31943,P55795,Q5BKZ1,Q13242,P31483,Q9UHX1,P51114,Q07666,Q96PU8,Q4G0J3,P61978,Q9BWF3,Q14011,O75525,Q06787,P98175,P31942,P62995,P98179 25 +Negative regulation of mrna metabolic process 0.4942709586084736 2.297281460889207 0.0216027186821647 1.0 0.3546539592976121 48 Q9H074,Q5VTR2,P16989,P38159,P35637,P22626,Q16539,P11940,Q13242,Q92804,O60506,Q92615,P61978,Q99729,Q14011,Q14103,P67809,Q06787,P98175 19 +G protein coupled receptor signaling pathway 0.5232579348903909 2.2953718395643192 0.021711823766745 1.0 0.3548808016846583 37 P30419,Q8TEY7,P07602,P11717,O43865,Q06481,Q99523,P04083,P42892,Q6RW13,Q9BYT8 11 +Regulation of ph 0.6324095478888138 2.291904169543664 0.021911173616028 1.0 0.3548808016846583 19 P50897,Q9Y487,Q93050,O75503,Q8N511 5 +Regulation of cellular ph 0.6324095478888138 2.291904169543664 0.021911173616028 1.0 0.3548808016846583 19 P50897,Q9Y487,Q93050,O75503,Q8N511 5 +Positive regulation of translation 0.4660269011853603 2.2861103133973923 0.0222478057863118 1.0 0.3587387920301728 56 Q14103,P67809,O60506,Q9H074,Q06787,Q9Y2R0,P16989,P51116,P08670,Q71RC2,Q14011,Q567V2,P51114,P98179,Q07666,Q9BRP8 16 +Protein catabolic process in the vacuole 0.8779537117773005 2.2839669334956123 0.0223734743451249 1.0 0.3589384985444473 6 Q8NHS3,Q8N511,P04062 3 +Lysosomal protein catabolic process 0.8779537117773005 2.2839669334956123 0.0223734743451249 1.0 0.3589384985444473 6 Q8NHS3,Q8N511,P04062 3 +Leukocyte mediated cytotoxicity 0.7160999644153481 2.2779069831542076 0.0227321201403343 1.0 0.361943329973112 12 Q9NUQ9,P01889,P07437,P04439 4 +Ion homeostasis 0.4047671389953158 2.2725243183355115 0.0230548609036687 1.0 0.3654351789907955 97 P30536,Q8NE01,Q9HD20,P50897,P42858,Q9Y487,P78417,Q93050,P09601,Q15904,P62942,O75503,Q8N511,P30519,Q7L0J3 15 +Negative regulation of proteolysis 0.4639134453814739 2.269570630974553 0.0232336472441496 1.0 0.3671611535814874 57 O43765,P30086,Q9H2J4,Q15392,P46379,Q06481,P19474,P07858 8 +Lipid localization 0.454488700689575 2.2527557102238225 0.0242745561604167 1.0 0.3770290744817668 66 P30536,P14174,P29375,P04083,Q9BQE5,Q9C0B1,Q8WTV0,Q9BZF1,O15260,O43772,O15118,P08183,Q14108,P04062,P35790,Q06124,Q9Y679,P07602,P31751,Q07954,P23786,P17900 22 +Organic hydroxy compound transport 0.5389781113114988 2.245479297929539 0.0247373797799723 1.0 0.380487319576905 29 P30536,P53985,O15118,Q8WTV0 4 +Phospholipid catabolic process 0.7789669464421612 2.239560542009576 0.0251194667639889 1.0 0.3819524936117631 9 Q8NHP8,Q8NCC3,Q8WTV0 3 +Sarcoplasmic reticulum calcium ion transport 0.8222655164583558 2.232852753219864 0.0255586561390197 1.0 0.3856314379832575 7 O75844 1 +Glycoside catabolic process 0.8620845461722698 2.218875351627195 0.026495205829258 1.0 0.3922899984579627 6 Q9NUJ1,P08236,Q9BTY2,P04062 4 +Glycosphingolipid metabolic process 0.7937916286436776 2.203847387035112 0.0275350787054906 1.0 0.3938821529496485 8 P16278,P06280,P06865,P04062 4 +Negative regulation of calcium ion transmembrane transport 0.815199064484951 2.202190002485403 0.0276518899655096 1.0 0.3946622223230503 7 P78417,P62942,P21796 3 +Nadh dehydrogenase complex assembly 0.5798235322237542 2.1940781578458175 0.0282297912174294 1.0 0.4011035581723098 22 Q9H061,O75306,Q96CU9,O43676 4 +Regulation of cell killing 0.8085881515941823 2.173405576008003 0.0297498055366249 1.0 0.4125262969050164 7 Q9NUQ9,P04439 2 +Negative regulation of immune effector process 0.7628320849332221 2.1643068565500343 0.0304408068635382 1.0 0.4191374481146665 9 Q96FV9,P01889,P09601,Q9UKG1,P04083,P04439 6 +Negative regulation of cell development 0.5746058398558025 2.158173974011788 0.0309143080825473 1.0 0.4191374481146665 22 P30536,Q9NQC3,Q8N0X7,Q06481,Q96G23 5 +Regulation of mitochondrion organization 0.5084351753226769 2.1543559407521724 0.0312122689904332 1.0 0.4191374481146665 36 P30536,P30419,Q8N2A8,O75832,P11233,P42858,Q96A26,Q9Y3I1,P21796,Q9Y6C9,O14737,Q9NUQ9,Q13501 13 +Positive regulation of peptidyl tyrosine phosphorylation 0.657799115301493 2.1525589638870404 0.0313533565446864 1.0 0.4193755379350228 14 Q8WXW3,Q92769,Q13432,P14174,Q9H223,Q06124 6 +Nervous system process 0.4138898569901442 2.1484240803464623 0.031680081525212 1.0 0.4217577240026657 84 Q9UQB8,O00264,O43924,P10253,Q92696,Q6P4Q7,O75844,P50897,Q15555,P78417,Q8N0X7,Q14168,Q14108,P04062,O60443,Q9BPZ3,O14773,P42858,Q9Y6M9,P17900 20 +Regulation of lipid biosynthetic process 0.5316484489122495 2.1427979507974397 0.0321293259433355 1.0 0.426490258335857 26 P30536,Q8WXW3,Q8WTV0,O75874,Q8NF37,O76054,P49748,O75477,P16435,P04083,P42345 11 +Regulation of hormone levels 0.4518124752931482 2.1419348188527527 0.0321987275116524 1.0 0.426490258335857 57 P30536,Q9HB40,P42892,O75844,P53985,P07858 6 +Antigen processing and presentation of peptide antigen 0.732358502367586 2.141268867617634 0.032252362194854 1.0 0.426490258335857 10 P10321,P01889,Q6P179,Q9UIQ6,P04439 5 +Regulation of glucose import 0.7577818452011231 2.1406190726624184 0.0323047694494573 1.0 0.426490258335857 9 P31751,Q9BZF1,Q06481,Q9UKG1,Q06124 5 +Organic acid transmembrane transport 0.5291852324165499 2.137197761309845 0.0325819100542115 1.0 0.426802597742303 27 P31751,O43772,Q9Y619,P08183,P53985,P23786,Q9UBX3,Q9H2D1 8 +Cellular iron ion homeostasis 0.6889708376894439 2.1358282456194044 0.0326934159497893 1.0 0.426802597742303 12 Q9Y487,Q8N511,P09601 3 +Negative regulation of peptidase activity 0.5109473562168397 2.1337759922158592 0.032861122028859 1.0 0.426802597742303 34 P30086,Q15392,Q06481,P07858 4 +Positive regulation of mrna splicing via spliceosome 0.6281473055023371 2.1321312555939227 0.0329960578152219 1.0 0.426802597742303 17 P62995,Q14011,P98179 3 +Sphingolipid biosynthetic process 0.6536382580714784 2.1291057042222463 0.033245515941213 1.0 0.426802597742303 14 Q06136,Q96G23,P04062 3 +Regulation of peptidyl tyrosine phosphorylation 0.5575593273661407 2.128245788138862 0.0333167102830724 1.0 0.426802597742303 23 Q9H2J4,Q8WXW3,Q92769,Q13432,P42345,P14174,P30153,O95684,Q9H223,Q06124 10 +Regulation of calcium ion transport 0.519094492605822 2.1281259276054194 0.0333266441515027 1.0 0.426802597742303 31 P30536,P42858,P78417,P21796,P62942,O14936 6 +Gliogenesis 0.476182261035897 2.124532334095949 0.0336256552567915 1.0 0.426802597742303 48 P30536,Q9NQC3,P15260,P08670,P04083,Q96N66,Q96G23,Q15022,P46109,Q92542,P04062,Q06124,Q92769,P31751,Q02750,O75306,Q8IXJ6,Q07954,P42345 19 +Regulation of glucose transmembrane transport 0.7280753544354406 2.120273963426892 0.0339829480613451 1.0 0.4273034637577248 10 P31751,Q9BZF1,Q06481,Q9UKG1,Q06124 5 +Membrane lipid catabolic process 0.7277518061538306 2.118686014947301 0.0341170110158928 1.0 0.4273034637577248 10 P50897,P06280,P06865,P04062,P17900 5 +Ceramide biosynthetic process 0.7748365297060056 2.118166202642493 0.0341609943983667 1.0 0.4273034637577248 8 Q96G23,P04062 2 +Genitalia development 0.9092079963732608 2.115983795524939 0.0343461857810769 1.0 0.4273034637577248 5 Q15392 1 +Ceramide catabolic process 0.8361186552363022 2.1113208373458017 0.0347447441900354 1.0 0.4273034637577248 6 P06280,P06865,P04062 3 +Antigen processing and presentation of endogenous antigen 0.8357304237667368 2.109702895485535 0.0348839549465693 1.0 0.4273034637577248 6 P10321,P04439,P01889,Q6P179 4 +Antigen processing and presentation of endogenous peptide antigen 0.8357304237667368 2.109702895485535 0.0348839549465693 1.0 0.4273034637577248 6 P10321,P04439,P01889,Q6P179 4 +Vacuole organization 0.4849658409177087 2.098389461196128 0.0358707554917006 1.0 0.4273034637577248 44 P50897,P54802,Q8NHS3,O75503,Q14108,P04062,Q8N511 7 +Amyloid precursor protein metabolic process 0.6312994013482667 2.095166521212039 0.0361561922252262 1.0 0.4273034637577248 16 Q9NQC3,P15260,Q9Y287,Q96IZ0,Q15392,O95197,P62942 7 +Carboxylic acid transport 0.5110956263358271 2.085228208741641 0.0370485904855724 1.0 0.4273034637577248 32 P07602,P14174,Q9Y619,P53985,Q9UBX3,Q9H2D1,Q7L0J3 7 +Sterol metabolic process 0.5047368798079932 2.081860788300815 0.0373551873286213 1.0 0.4273034637577248 34 P61916,Q14739,Q8WTV0,P37268,Q9UKR5,Q16850,Q15392,O76054,P48449,O15118,Q14534,P04062,Q15800,Q9BQE5 14 +Glycerophospholipid catabolic process 0.8288418825550629 2.080947234030614 0.0374387360722461 1.0 0.4273034637577248 6 Q8WTV0 1 +Glycerolipid catabolic process 0.8288418825550629 2.080947234030614 0.0374387360722461 1.0 0.4273034637577248 6 Q8WTV0 1 +Cellular hormone metabolic process 0.6372233928043434 2.0800793875858066 0.0375182518707861 1.0 0.4273034637577248 15 P30536,Q9HB40 2 +Negative regulation of gliogenesis 0.8988047051331153 2.075299938246154 0.0379587451792609 1.0 0.4273034637577248 5 P30536 1 +Response to molecule of bacterial origin 0.5028998692330877 2.0664558577657592 0.0387854563400453 1.0 0.4281941408133581 34 P30536,Q16539,Q8WTV0,Q92769,P14174,P08670,O43823,Q8IXJ6,Q9NUQ9,Q53EL6 10 +Antigen processing and presentation of peptide antigen via mhc class i 0.7399142570959851 2.0563046572221144 0.0397531596797777 1.0 0.4373537723797773 9 P10321,P01889,Q6P179,Q9UIQ6,P04439 5 +Crd mediated mrna stabilization 0.7390936757383846 2.0524135194459623 0.0401294917534909 1.0 0.4375727903317018 9 Q14103,P67809,O60506,Q9H074 4 +Negative regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay 0.7390936757383848 2.0524135194459623 0.0401294917534909 1.0 0.4375727903317018 9 Q14103,P67809,O60506,Q9H074 4 +Negative regulation of nervous system development 0.5947219374455065 2.051814524433531 0.0401876912083161 1.0 0.4375727903317018 19 P30536,Q9NQC3,Q8N0X7,Q06481,Q96G23 5 +Positive regulation of cell killing 0.8214376465939405 2.049938064501408 0.0403704751111084 1.0 0.4375727903317018 6 Q9NUQ9,P04439 2 +Regulation of leukocyte mediated cytotoxicity 0.8214376465939405 2.049938064501408 0.0403704751111084 1.0 0.4375727903317018 6 Q9NUQ9,P04439 2 +Sphingoid metabolic process 0.8919842768114598 2.048534440548824 0.0405076610205741 1.0 0.4375727903317018 5 Q06136,P04062 2 +Glycoside metabolic process 0.7381575830970311 2.0479726129122504 0.0405626829895202 1.0 0.4375727903317018 9 Q9NUJ1,P08236,Q9BTY2,P04062 4 +Response to axon injury 0.6558292442828116 2.0456333442428005 0.0407924582684307 1.0 0.4381386577068565 13 P30536,Q96G23,P00374 3 +Regulation of mrna catabolic process 0.4252689700909365 2.044739257413052 0.0408805710978994 1.0 0.4383420965268845 74 Q9H074,Q96B26,P16989,P51116,P08670,Q13310,P35637,Q9C0B1,P11940,Q969T7,Q92945,P51114,Q92804,O60506,Q99729,Q14011,Q14103,P67809,Q06787,P98175,Q96C86 21 +Regulation of alternative mrna splicing via spliceosome 0.5086390340598805 2.0437085939922195 0.0409823437099028 1.0 0.4386910677190105 31 Q06787,P98175,P51116,Q9UHX1,P38159,P62995,P31483,P51114,Q9BWF3,Q07666,O75525 11 +Natural killer cell mediated immunity 0.7568079713600405 2.0359026571074508 0.0417601309678223 1.0 0.4447629410808242 8 P01889,P07437,P04439 3 +Neuron projection regeneration 0.7099602513067721 2.030936478806527 0.0422614387102331 1.0 0.4493468743401801 10 P30536,Q96G23,P00374 3 +Regulation of nitric oxide metabolic process 0.7094509744868301 2.028412295878539 0.0425181862104959 1.0 0.4513195075643433 10 P30536,P06280 2 +Response to thyroid hormone 0.8148558300073457 2.0222860126147735 0.0431468128018317 1.0 0.4566221285477988 6 P07858 1 +Pinocytosis 0.7538077450543232 2.0221403762790704 0.0431618518226497 1.0 0.4566221285477988 8 Q9UKG1,Q9H223,P50897,Q06481 4 +Lipoprotein biosynthetic process 0.7309718759957794 2.013811365163025 0.0440293420398691 1.0 0.4634783064894536 9 P04062 1 +Negative regulation of hydrolase activity 0.4400007769951216 2.0083557418899716 0.0446055024099774 1.0 0.467988524456998 55 P30086,Q15392,P29375,Q4VCS5,Q06481,Q99523,P04083,P62942,Q96K76,Q9Y624,P07858 11 +Immune response regulating cell surface receptor signaling pathway 0.515213609406608 2.0067005487561507 0.0447815575680889 1.0 0.4683097812557754 25 P45985,Q96IZ0,P46379,Q06481,Q9UKG1,P46109,Q07666,P04439 8 +Cellular carbohydrate catabolic process 0.6069810959245785 2.002963311017323 0.0451812266525866 1.0 0.4716860515608589 17 P35573,P10253,P08236,Q14108,Q9NUJ1 5 +Diol biosynthetic process 0.7688138522733474 1.9982307238886596 0.0456916520699755 1.0 0.472168743592303 7 O15270,P04062 2 +Diol metabolic process 0.7688138522733474 1.9982307238886596 0.0456916520699755 1.0 0.472168743592303 7 O15270,P04062 2 +Neuron apoptotic process 0.4785816426779696 1.9950442819211671 0.0460380504341926 1.0 0.4728413705048276 42 O76024,Q01105,Q13564,P50897,P45985,Q07820,Q96A26,Q9NR28,Q92542,O95831,P31751,P49327,P09601,O43813,P04062,O75312 16 +Dna modification 0.5097950930209114 1.9870912964197196 0.0469122805758801 1.0 0.4771799711225562 27 Q9NRW3,Q8N2A8,Q5RKV6,Q8NB78,Q8N3C0,O95983,Q03164,O75844 8 +Negative regulation of cell population proliferation 0.4012259082570113 1.983754545106775 0.0472832096527364 1.0 0.4785769449865496 84 P30536,Q15392,Q13363,Q96G23,P50402,Q92990,O14737,Q53EL6,P09601,P52756,O60443,Q96DY7,Q32P28,P98175,O14964,Q96IZ0,Q02750,Q06481,Q8IXJ6,Q01085,O14936 21 +Enzyme linked receptor protein signaling pathway 0.3835646669676122 1.9825689853944528 0.0474155945805392 1.0 0.4785769449865496 96 Q9NQC3,P08670,Q9UKG1,Q9UQB8,P62993,Q9UIQ6,Q16539,Q9Y5X3,O95470,Q9BZF1,P43490,P62942,Q06330,P46109,Q53EL6,P10586,P11717,Q8N0X7,Q99523,Q15750,Q9UNH7,Q9HCD5,Q06124,Q92896,P31751,O14964,Q06481,P04792,Q8IXJ6,Q07954,Q92572,Q96PK6 32 +Cellular monovalent inorganic cation homeostasis 0.5244718085748517 1.9802786358764928 0.0476722280405061 1.0 0.4785769449865496 24 P50897,Q9Y487,Q93050,O75503,Q8N511 5 +Determination of adult lifespan 0.8045597674704812 1.9788659766234569 0.0478310978143796 1.0 0.4785769449865496 6 O75844 1 +Protein localization to cytoskeleton 0.6194506365843401 1.9763783672446744 0.0481119397796356 1.0 0.4785769449865496 15 O15344,P29372,Q15154,Q8WXW3,Q14789,Q15555,Q00839,Q96R06,Q15691,Q13561 10 +Neutral lipid metabolic process 0.7222943596339392 1.972389886212406 0.0485651155082582 1.0 0.4785769449865496 9 Q8NCC3,Q8WTV0 2 +T cell mediated cytotoxicity 0.801319285345399 1.9651594259021852 0.049395788386457 1.0 0.4785769449865496 6 Q9NUQ9,P04439 2 +Regulation of mitochondrial gene expression 0.7206296261131949 1.9644225027144655 0.0494811153587182 1.0 0.4785769449865496 9 Q567V2 1 +Glycolipid catabolic process 0.8004700430129029 1.9615640870473896 0.0498132568539664 1.0 0.4785769449865496 6 P17900,P06280,P06865,P04062 4 +Dna methylation 0.6087742547613515 1.9605608155163237 0.0499302771357117 1.0 0.4785769449865496 16 Q03164,Q8NB78,O75844 3 +Immune response regulating signaling pathway 0.4558901341872522 1.9570657785796015 0.0503397352233598 1.0 0.4785769449865496 49 O75179,Q9NQC3,P45985,Q9NUD5,Q96IZ0,P46379,Q06481,Q9UKG1,Q14671,Q9NPR9,P46109,O43657,Q07666,P17931,P04439 15 +Peptidyl proline hydroxylation 0.7983633933266013 1.952639642867103 0.0508623102539946 1.0 0.4785769449865496 6 Q32P28,P13674 2 +Regulation of lysosomal lumen ph 0.8671329062277283 1.9503958904127836 0.0511289513077044 1.0 0.4785769449865496 5 Q8N511,O75503 2 +Low density lipoprotein particle clearance 0.7378528886328729 1.94861077695165 0.0513419241488111 1.0 0.4785769449865496 8 Q92945,Q8WTV0,P09601 3 +Chemical homeostasis 0.4065793285047104 1.9466152188633723 0.0515808826614823 1.0 0.4785769449865496 162 P30536,Q9NQC3,Q5BJF2,P42785,O15254,O75503,P53985,P30519,Q8WTV0,Q8NF37,Q9Y487,Q93050,O15260,P62942,Q8N511,P50897,P78417,P09601,O15118,P04062,Q06124,Q8NE01,Q9HD20,P42858,Q9Y6C9,Q06481,Q15904,P62995,Q7L0J3 29 +Positive regulation of mitochondrial translation 0.8659002845410892 1.945503521205531 0.0517144063364154 1.0 0.4791143171840126 5 Q567V2 1 +Modification of synaptic structure 0.7565248723816448 1.9434240722354656 0.0519649410878995 1.0 0.4800318245976956 7 O00264,P35080,Q9UQB8 3 +Cellular modified amino acid metabolic process 0.4627234110561401 1.939324738556945 0.0524618084022014 1.0 0.4832129067510913 46 O75874,O60725,P78417,Q92820,P21266,Q8NCC3,P00374,Q9UHG3,Q9H7Z7,Q9H2D1,P07858 11 +Transition metal ion homeostasis 0.5429071853373301 1.9372262686476431 0.0527176905383504 1.0 0.4837979708940766 22 Q9Y487,Q8N511,P30519,P09601 4 +Alternative mrna splicing via spliceosome 0.4743141054390519 1.9365216169781496 0.0528038476030279 1.0 0.4837979708940766 41 Q06787,P98175,P51116,Q9UHX1,P38159,Q13242,P62995,P31483,P51114,Q9BWF3,Q07666,O75525 12 +Organic acid transport 0.4720319247808566 1.935106873457963 0.0529771822352225 1.0 0.4837979708940766 42 P31751,P14174,P29375,O43772,Q9Y619,P08183,P53985,Q9UBX3,Q9H2D1,Q7L0J3 10 +Response to bacterium 0.4327188160165199 1.930839089689386 0.053502954623942 1.0 0.4837979708940766 55 P30536,Q16539,O75179,Q8WTV0,Q92769,Q5KU26,P14174,P01889,P08670,Q9NZ08,Q9BTY2,O43823,Q9UQB8,Q8IXJ6,Q9NUQ9,Q06330,Q53EL6,P04439 18 +Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway 0.7536692966416244 1.930643319545141 0.0535271768123561 1.0 0.4837979708940766 7 Q9NUD5,O75179,O43657 3 +Antigen processing and presentation 0.5759623106032702 1.9301023494004277 0.0535941574195426 1.0 0.4837979708940766 19 P10321,P01889,P04062,Q6P179,Q9UIQ6,P04439 6 +Negative regulation of calcium ion transport 0.7332157695118346 1.9271326337525096 0.0539631027282128 1.0 0.4856120933738924 8 P78417,P62942,P21796 3 +Sensory perception 0.4962478381374076 1.924419798976812 0.0543019846963017 1.0 0.4860334421192998 30 P50897,Q15555,O43924,Q92696,Q14108,Q6P4Q7,O60443,Q9Y6M9 8 +Negative regulation of rna catabolic process 0.4858534177117369 1.922459398141688 0.0545479777685713 1.0 0.487546593962534 34 Q14103,P67809,O60506,Q9H074,Q06787,P98175,P16989,P35637,Q08J23,Q99729,Q14011,Q92804 12 +Cellular response to inorganic substance 0.4932132029617688 1.9179321948891632 0.0551196093171126 1.0 0.4895770789702253 31 Q99829,P30536,Q14103,Q06787,Q92542,P09601,Q14168 7 +Regulation of plasma lipoprotein particle levels 0.6625446257388917 1.9166416657170775 0.0552834708682099 1.0 0.4895770789702253 11 Q92945,Q8WTV0,P09601 3 +Negative regulation of glial cell proliferation 0.990747330960855 1.916386230951996 0.0553159521134103 1.0 0.4895770789702253 2 P30536 1 +Lymphocyte mediated immunity 0.4928159193207782 1.914673913064172 0.0555341024552744 1.0 0.4903596222475112 31 Q5RKV6,P52701,P68371,Q96FV9,P01889,Q96FZ2,P13051,Q12888,P53634,O96028,Q9UQ84,P07437,Q9NUQ9,P04439 14 +Regulation of rna export from nucleus 0.7096593969930614 1.911752330240428 0.0559079687304309 1.0 0.4903596222475112 9 Q9BYW2,Q08J23,Q07666,Q9ULX6 4 +Regulation of tube size 0.7296059899523714 1.910379732105023 0.0560843385150398 1.0 0.4903596222475112 8 Q9HB40 1 +Outer mitochondrial membrane organization 0.8552587898231198 1.9031713167663036 0.0570181945826977 1.0 0.4936124304242563 5 Q9Y512,Q9NS69 2 +Antigen processing and presentation of exogenous antigen 0.78590523342281 1.8996960798253608 0.0574730150888342 1.0 0.4958030048573447 6 Q9UIQ6 1 +Smad protein signal transduction 0.7272813394279835 1.8995757887222124 0.0574888120086434 1.0 0.4958030048573447 8 Q07954,Q96PK6,Q9UIQ6 3 +Vitamin transmembrane transport 0.8541749064004673 1.898850083948248 0.0575841899282003 1.0 0.4958030048573447 5 Q9H2D1,Q8WTV0 2 +Thymus development 0.7456883028044506 1.8948327717472704 0.0581145600174461 1.0 0.4996905927144593 7 O75844,Q02750 2 +Amyloid precursor protein catabolic process 0.6282418755339938 1.89259294517253 0.058412022679873 1.0 0.5008176342385868 13 Q15392,Q9NQC3,P15260,O95197 4 +Regulation of response to biotic stimulus 0.4257916413854949 1.8916295546686572 0.0585403552493342 1.0 0.5008176342385868 62 Q16543,O75179,Q8IXJ6,P14174,P01889,Q9NUD5,Q9NZ08,Q06481,O94992,Q9UKG1,P19474,Q14671,Q96ST3,O75844,O43657,Q96PK6,Q06124,P04439 18 +Monovalent inorganic cation homeostasis 0.498000816262018 1.8837879968647475 0.0595936578038769 1.0 0.5067014856721469 26 P50897,Q9Y487,Q93050,O75503,Q8N511 5 +Alcohol biosynthetic process 0.4840416153245442 1.8833749892077027 0.0596495673522836 1.0 0.5067014856721469 33 Q14739,Q16850,Q15392,O15270,P48449,P04062,Q15800 7 +Regulation of system process 0.4450552324656571 1.8799322909064 0.0601173063879307 1.0 0.5068128470978095 50 P78417,P42892,Q9UQB8,O75844,P04062 5 +Dna methylation or demethylation 0.5461072125256325 1.8789322886423552 0.0602537393576885 1.0 0.5068128470978095 21 Q9NRW3,Q8N2A8,Q8NB78,O95983,Q03164,O75844 6 +Protein quality control for misfolded or incompletely synthesized proteins 0.6541949942660399 1.8727896461872275 0.0610974382925564 1.0 0.5068128470978095 11 Q16740,P46379 2 +Regulation of appetite 0.9793594306049828 1.8701493615325009 0.0614630794236916 1.0 0.5068128470978095 2 Q9UMX5 1 +Negative regulation of response to food 0.9793594306049828 1.8701493615325009 0.0614630794236916 1.0 0.5068128470978095 2 Q9UMX5 1 +Regulation of response to food 0.9793594306049828 1.8701493615325009 0.0614630794236916 1.0 0.5068128470978095 2 Q9UMX5 1 +Nerve development 0.7789154727970877 1.869868054985949 0.061502142878052 1.0 0.5068128470978095 6 Q9H061 1 +Steroid metabolic process 0.4243718453473446 1.8684753406147236 0.0616958441889274 1.0 0.5076833175237818 61 P30536,Q8WTV0,Q16850,Q15392,P48449,O15118,P04062,Q15800 8 +Regulation of autophagy of mitochondrion 0.6235586053924936 1.8663797229885009 0.0619882579846582 1.0 0.5078211309504254 13 P30536,P21796 2 +Neuromuscular process 0.5553677117176141 1.8661450593508817 0.0620210732612345 1.0 0.5078211309504254 20 O14773,P78417,Q8N0X7,P04062,O75844,P17900 6 +Mitochondrial transmembrane transport 0.4575306899984589 1.865109472556866 0.0621660610765013 1.0 0.5078211309504254 45 Q99595,O60830,P21796,O43772,O75964,Q9H2D1 6 +Negative regulation of cell activation 0.5846711831401938 1.8650093149664544 0.062180098547119 1.0 0.5078211309504254 17 Q8WXW3,Q96FV9,Q9Y3I1,Q96IZ0,Q92990,P09601,P04083,P17931 8 +Inorganic anion transmembrane transport 0.7380076823757142 1.8602461823849297 0.0628507038574288 1.0 0.5103873607391559 7 Q9UHG3 1 +Plasma lipoprotein particle clearance 0.6987199189258141 1.858944484714212 0.0630350077546775 1.0 0.5103873607391559 9 Q92945,Q8WTV0,P09601 3 +Response to testosterone 0.6745947208602326 1.8540416844992516 0.0637331965903944 1.0 0.5113817433920247 10 P30536,Q13126 2 +Positive regulation of rna splicing 0.5310786773604064 1.8535679840351331 0.0638009915383379 1.0 0.5113817433920247 22 P38159,P62995,O75312,P98179,Q14011,Q9NW64 6 +Ribonucleoprotein complex localization 0.7362888347926895 1.8524895769477103 0.0639555529102893 1.0 0.5113817433920247 7 Q9BYW2,Q08J23,Q9ULX6 3 +Neutral lipid biosynthetic process 0.8424311657003946 1.8519191038830307 0.0640374402319046 1.0 0.5113817433920247 5 Q8WTV0 1 +Vitamin transport 0.7355572259015711 1.8491862460119683 0.0644309240642861 1.0 0.5113817433920247 7 Q9H2D1,Q8WTV0 2 +Regulation of dna methylation 0.7161670653106944 1.847757500119246 0.0646374316322639 1.0 0.5113817433920247 8 O75844,Q03164 2 +Autophagy of mitochondrion 0.4933574397780445 1.8475491141515827 0.0646675968416727 1.0 0.5113817433920247 26 P30536,P21796,P42858,P04062 4 +Calcium ion import 0.6493077992082674 1.8470331662360824 0.0647423336124641 1.0 0.5113817433920247 11 O75844,P21796 2 +Neuron death 0.4212295897820723 1.840689078280526 0.0656671353532849 1.0 0.5113817433920247 62 Q01105,Q9Y3I1,Q15392,O43813,O75312,Q13564,Q9UMX5,Q96A26,O95831,O76024,P50897,P45985,Q9NR28,Q92542,P49327,P09601,P04062,Q07820,P31751 19 +Transport of virus 0.733388433470423 1.8393874504496313 0.0658582186318306 1.0 0.5113817433920247 7 O00505,O60684 2 +Negative regulation of immune system process 0.4594784135775841 1.8392479440889715 0.0658787257909372 1.0 0.5113817433920247 43 Q8WXW3,Q9H000,P14174,Q9Y3I1,Q96FV9,P01889,Q92990,Q96IZ0,P09601,Q9UKG1,P04083,P28070,P19474,P10644,P17931,P04439 16 +Regulation of lipid metabolic process 0.4496424795002423 1.839041590253409 0.0659090690461094 1.0 0.5113817433920247 47 P30536,Q8WXW3,Q8WTV0,O75874,Q8NF37,P07602,P31751,O76054,Q06481,O60869,P04083,Q8NBJ4,Q96N66,O75844,Q96G23 15 +Phosphatidylcholine catabolic process 0.970106761565838 1.832496342585716 0.0668775061580191 1.0 0.5137003109374149 2 Q8WTV0 1 +Multicellular organism aging 0.6928473080524686 1.8304800750858936 0.0671781835268061 1.0 0.5139888304345075 9 O75844 1 +Negative regulation of intrinsic apoptotic signaling pathway 0.4846672695302154 1.830206656985036 0.0672190427412839 1.0 0.5139888304345075 30 O95881,Q07820,P16989,P45880,Q96K76 5 +Sensory perception of light stimulus 0.6011583233332954 1.8283396532346223 0.0674985921360513 1.0 0.5139888304345075 14 P50897,Q15555,O43924,Q92696,Q6P4Q7 5 +Regulation of macroautophagy 0.451009200567346 1.826785699482487 0.0677319968659238 1.0 0.5144522990182567 46 Q9Y487,Q93050,O15270,P21796,P09601,O15118,P04062,P36543 8 +Endocrine process 0.966548042704626 1.817995044337388 0.0690648902138746 1.0 0.5197912224291253 2 P42892 1 +Detection of biotic stimulus 0.9405270655270612 1.8139805901220376 0.0696807140823787 1.0 0.5231832762322679 4 P30536,Q8WTV0,P04439 3 +Regulation of toll like receptor signaling pathway 0.7076466139721573 1.8078511371387271 0.0706296723969148 1.0 0.5265649811520583 8 Q9NPR9,Q9NQC3,Q06481 3 +Lysosomal lumen acidification 0.938352161949824 1.8058211348429805 0.0709462830603546 1.0 0.5276837978327084 4 Q8N511,O75503 2 +Organophosphate ester transport 0.5122455095669609 1.800980989932612 0.0717058763078495 1.0 0.5320844709166773 23 Q8WTV0,Q8TB61,Q9BZF1,P08183,Q14108,Q9H2D1 6 +Glial cell proliferation 0.93499655619538 1.7932224929909475 0.0729373548657761 1.0 0.5377189609311418 4 P30536,Q96G23 2 +Reactive nitrogen species metabolic process 0.5730769333417592 1.7926107590910758 0.0730351848435957 1.0 0.5377189609311418 17 P30536,P06280,O43169 3 +Response to increased oxygen levels 0.6850288549849651 1.7924608173521792 0.073059180268536 1.0 0.5377189609311418 9 Q92769,Q9Y487,Q15904,Q8N511,P61421 5 +Mitochondrial outer membrane permeabilization 0.7210562075944715 1.7834907348539526 0.0745064548628813 1.0 0.5410468228903328 7 P45880 1 +Response to progesterone 0.7575562405533534 1.7781834478320762 0.075373730535567 1.0 0.5418541978128842 6 P30536 1 +Copii coated vesicle cargo loading 0.6820465673476543 1.7779220120664805 0.0754166644265368 1.0 0.5418541978128842 9 Q15437 1 +Macromolecule depalmitoylation 0.8232443466611555 1.7748174593591903 0.0759280325466078 1.0 0.5443513626232372 5 P50897,Q9UMR5 2 +Negative regulation of immune response 0.5200177109582691 1.774769058687025 0.0759360272303837 1.0 0.5443513626232372 22 Q9H000,Q96FV9,P01889,P09601,P28070,P04083,P19474,P17931,P04439 9 +Protein localization to vacuole 0.5701377265510679 1.7741833895359562 0.0760328208214999 1.0 0.5444293621986953 17 Q9NQC3,Q92783,O14964,Q14108,Q9Y2T2 5 +Sulfur compound transport 0.6990093371909029 1.76724023466723 0.0771880041289541 1.0 0.5508337636995294 8 Q70HW3,Q9UBX3 2 +Mitochondrial outer membrane permeabilization involved in programmed cell death 0.698777609675814 1.7661485425550894 0.0773709313526964 1.0 0.5515181012171401 8 P45880 1 +Regulation of phospholipid catabolic process 0.9526690391459108 1.7613439310148562 0.0781802087577274 1.0 0.5532436063380928 2 Q8WTV0 1 +Aminoglycan catabolic process 0.8197124314165466 1.760568716964845 0.0783114273134399 1.0 0.5532436063380928 5 P16278,P54802,P08236 3 +Glycosaminoglycan catabolic process 0.8197124314165466 1.760568716964845 0.0783114273134399 1.0 0.5532436063380928 5 P16278,P54802,P08236 3 +Regulation of nervous system process 0.7151372485561523 1.7565564215822798 0.07899344641601 1.0 0.5543407121015639 7 Q9UQB8,P04062 2 +Histone h4 k16 acetylation 0.6967243553181472 1.7564705868986668 0.079008089409565 1.0 0.5543407121015639 8 Q03164 1 +Regulation of mitochondrial membrane permeability involved in apoptotic process 0.6960720780859783 1.7533942724772669 0.0795343534654162 1.0 0.5563015429473983 8 P45880 1 +Regulation of response to extracellular stimulus 0.9240418078510892 1.7520133411200038 0.0797715139214858 1.0 0.5573451860203482 4 Q9UMX5 1 +Walking behavior 0.9226117141672994 1.746624887381728 0.0807024272749381 1.0 0.5596194551043798 4 O75844 1 +Cellular response to increased oxygen levels 0.7494654312188136 1.7432484167781748 0.0812902314763128 1.0 0.5596194551043798 6 Q9Y487,P49327,Q15904,Q8N511,P61421 5 +Negative regulation of cation channel activity 0.7489885208911073 1.7411857580588763 0.0816510228533635 1.0 0.5596194551043798 6 P78417,Q06787,P62942 3 +Fat cell differentiation 0.4803820159741311 1.7377321854592709 0.0822580147294116 1.0 0.5596194551043798 25 P31751,Q13363,Q9NZ08,Q9BZF1,Q99523,Q86X55,Q8IXJ6,Q8N4Q0,Q9C0B1 9 +Cellular response to oxygen levels 0.4713684450684426 1.737414558485616 0.0823140233545811 1.0 0.5596194551043798 31 Q96A26,Q9Y487,P55786,O95831,P09601,Q15904,O75306,Q8IXJ6,Q06330,Q8N511,P61421,P42345 12 +Response to osmotic stress 0.5641795224047815 1.7367389575700811 0.0824332580038478 1.0 0.5596194551043798 17 P30536,P16989 2 +Regulation of protein dephosphorylation 0.4788891944314366 1.7339019049770026 0.0829354898184642 1.0 0.5596194551043798 26 Q12972,P17931,P42858,Q86XL3,Q92797,P62942,P04062,P42345 8 +Protein hydroxylation 0.5999208041278727 1.7330852230761913 0.0830805223979898 1.0 0.5596194551043798 13 Q32P28,Q92791,P13674,O75718 4 +Positive regulation of autophagy 0.4797172991712715 1.7325377130427264 0.0831778684005029 1.0 0.5596194551043798 25 O15270,P19474,P21796,P09601 4 +Modification of postsynaptic structure 0.7459453546704266 1.7280150586511878 0.0839855246354277 1.0 0.5596194551043798 6 P07737,P35080,Q9UQB8 3 +Establishment of protein localization to organelle 0.3933138405580685 1.725443142520665 0.0844476420376993 1.0 0.5596194551043798 169 P30536,P55735,Q9NS69,Q8TB36,Q99567,Q99595,O60830,Q9Y3I1,P55786,Q10713,Q9UKG1,O14925,Q9UFC0,P40855,O75312,P57740,Q5JRX3,Q9NW64,Q16539,O00505,Q9Y512,P11233,Q92973,O00629,P52294,P46379,O14737,Q15629,O60684,O43765,Q9BW27,Q92783,Q9UHB9,Q99523,Q14108,Q13501,P30419,O14964,Q8N4H5,Q06481,Q9Y2T2 41 +Antigen processing and presentation of exogenous peptide antigen via mhc class i 0.9437722419928872 1.7249547502963911 0.0845356275163868 1.0 0.5596194551043798 2 Q9UIQ6 1 +Dna methylation involved in gamete generation 0.9423487544484006 1.719127519077141 0.0855911549313575 1.0 0.5626464199170254 2 Q8NB78 1 +Positive regulation of lymphocyte mediated immunity 0.5683385457610497 1.7144950632557598 0.0864378429630996 1.0 0.5651063981057282 16 Q9NUQ9,Q96FZ2,O96028,P04439 4 +Regulation of systemic arterial blood pressure 0.7424029999823827 1.712664730434102 0.0867742372635802 1.0 0.5651063981057282 6 P42785 1 +Negative regulation of defense response 0.4735758759035372 1.7119634916106148 0.0869033966762098 1.0 0.5651063981057282 28 Q9H000,Q8IXJ6,P01889,P28070,P19474,P04062,Q96KB5,O43657,P04439 9 +Positive regulation of glucose import 0.8072675454221545 1.7102293424833828 0.0872234717488282 1.0 0.5651063981057282 5 Q9UKG1,Q9BZF1,Q06124,P31751 4 +Positive regulation of glucose transmembrane transport 0.8072675454221545 1.7102293424833828 0.0872234717488282 1.0 0.5651063981057282 5 Q9UKG1,Q9BZF1,Q06124,P31751 4 +Negative regulation of natural killer cell mediated immunity 0.9398576512455514 1.7089267304170712 0.0874645223949395 1.0 0.5651063981057282 2 P04439 1 +Detection of other organism 0.9398576512455514 1.7089267304170712 0.0874645223949395 1.0 0.5651063981057282 2 P04439 1 +Protection from natural killer cell mediated cytotoxicity 0.9398576512455514 1.7089267304170712 0.0874645223949395 1.0 0.5651063981057282 2 P04439 1 +Positive regulation of calcium ion transport 0.5514088946231396 1.7088358515852862 0.0874813597193813 1.0 0.5651063981057282 18 P30536,P78417,O14936 3 +Regulation of defense response 0.3861361278189465 1.7076845539520826 0.08769488970166 1.0 0.5659088758038898 81 Q9UKG1,P04083,P43243,P04439,Q16543,P01889,Q9NZ08,O75844,Q53EL6,Q9NUD5,P04062,Q96ST3,Q96KB5,Q06124,Q9H000,Q06481,P28070,O94992,P19474,Q8IXJ6,P60900,O43657,Q96PK6 23 +Negative regulation of transmembrane transport 0.5594351709292816 1.7068389910650807 0.0878519829972857 1.0 0.5663458964942009 17 Q06787,P31751,P78417,P21796,Q06481,P62942 6 +Glycosylceramide catabolic process 0.9387900355871917 1.7045537677776783 0.088277680076116 1.0 0.5672006712057619 2 P04062 1 +Mitochondrial membrane organization 0.4506590971482557 1.7034904083013216 0.0884763314883727 1.0 0.5672006712057619 40 P45880,P30419,Q9Y512,Q9NS69 4 +Positive regulation of cytoplasmic translation 0.6088199804246219 1.703209011962329 0.0885289607711032 1.0 0.5672006712057619 12 Q14103,P67809,O60506,Q9H074,P16989 5 +Intracellular transport of virus 0.7402094762473523 1.703149153451111 0.0885401593040722 1.0 0.5672006712057619 6 O00505,O60684 2 +Negative regulation of response to wounding 0.8029355922037971 1.6926592042600828 0.0905203547675239 1.0 0.5748844359247242 5 Q96G23 1 +Lipoprotein localization 0.7006547598152778 1.6903717657561288 0.09095685314074 1.0 0.5763256094404005 7 O15260,A6NIH7,Q07954 3 +Regulation of mrna export from nucleus 0.7371703052531912 1.689952337239751 0.0910370735442387 1.0 0.5763256094404005 6 Q9BYW2,Q08J23,Q9ULX6 3 +Pattern recognition receptor signaling pathway 0.4725425009523263 1.6837130381716685 0.0922371403536344 1.0 0.5825992244606334 26 O75179,Q9NQC3,Q5KU26,Q9NUD5,Q06481,Q9UKG1,Q14671,Q9NPR9,O43657 9 +Sterol biosynthetic process 0.4962821711461189 1.6833680230199857 0.0923038695531759 1.0 0.5825992244606334 23 Q14739,Q16850,P37268,Q9UKR5,Q15392,O76054,P48449,Q14534,Q15800 9 +Fibroblast proliferation 0.5762154408173206 1.6823346963392043 0.0925039567075112 1.0 0.5832811678164165 14 O75844,Q96IZ0,P14174 3 +Regulation of autophagy of mitochondrion in response to mitochondrial depolarization 0.7346342214826889 1.6789287842098162 0.0931659239473974 1.0 0.5862884409678822 6 P04062 1 +Regulation of rig i signaling pathway 0.7343016395021507 1.6774824015427965 0.093448187948109 1.0 0.5864308272568279 6 Q9NUD5,O75179 2 +Vascular process in circulatory system 0.4715044017024027 1.675485150282772 0.0938390822387771 1.0 0.5870269142617283 26 Q9HB40,P08183,P42892,Q07954,P53985 5 +Er associated misfolded protein catabolic process 0.7325877039907925 1.6700258250579816 0.0949142542040395 1.0 0.5885376001794952 6 P46379 1 +Retinal rod cell development 0.9302491103202885 1.6695455814002458 0.0950093048735398 1.0 0.5885376001794952 2 P54802 1 +Retinal rod cell differentiation 0.9302491103202885 1.6695455814002458 0.0950093048735398 1.0 0.5885376001794952 2 P54802 1 +Camera type eye photoreceptor cell differentiation 0.9302491103202885 1.6695455814002458 0.0950093048735398 1.0 0.5885376001794952 2 P54802 1 +Phototransduction visible light 0.930249110320288 1.669545581400245 0.09500930487354 1.0 0.5885376001794952 2 P30419 1 +Detection of visible light 0.930249110320288 1.669545581400245 0.09500930487354 1.0 0.5885376001794952 2 P30419 1 +Intermembrane lipid transfer 0.7322376181271777 1.6685021903526525 0.095216077480646 1.0 0.5891461426267135 6 P30536,Q9BZF1 2 +Purine ribonucleoside metabolic process 0.6769946529829474 1.6630396750873566 0.0963044938947628 1.0 0.5910664399224107 8 Q13126 1 +Intracellular protein transmembrane transport 0.5442996280781455 1.6627195655367717 0.0963685838483832 1.0 0.5910664399224107 18 Q99595,O60830,P31751 3 +Protein deneddylation 0.6768805083517618 1.662496899557384 0.0964131844961042 1.0 0.5910664399224107 8 Q99627,Q92905,Q9BT78,Q9UNS2,Q7L5N1 5 +Cellular response to nutrient 0.7300884000896593 1.6591442383212176 0.0970867307686336 1.0 0.5910664399224107 6 Q96C86,P09601 2 +Cellular response to virus 0.5039119231100717 1.6590960270390935 0.0970964437366623 1.0 0.5910664399224107 22 O75179,Q06787,Q9NUD5,Q14671,O60443,Q14258,O43657 7 +Establishment of protein localization to membrane 0.3967363376942163 1.6527653841146432 0.0983786216213187 1.0 0.5969646254786602 71 O43765,P30419,Q9HD20,Q9Y512,Q9NS69,P31751,O60725,P46379,Q15904,O14737,O15118,Q15629,P43307,Q9Y4C2 14 +Positive regulation of actin filament polymerization 0.6564163866459336 1.6521672693391851 0.0985004567663132 1.0 0.5969646254786602 9 P35080,P07737,Q9UQB8,P62993,P42345 5 +Positive regulation of mitochondrion organization 0.5421156868666581 1.648519505075534 0.0992461115103897 1.0 0.599544908142364 18 P30419,Q8N2A8,P42858,P21796,O14737 5 +Regulation of anion channel activity 0.9249110320284696 1.6476449240662965 0.0994255560402186 1.0 0.5999472401831839 2 Q9Y4C2 1 +Response to mitochondrial depolarisation 0.691045517627301 1.6462441054546209 0.0997135120536591 1.0 0.5999472401831839 7 Q16543,Q13501,P04062 3 +Response to wounding 0.4002828798298449 1.6460626728196135 0.0997508564394671 1.0 0.5999472401831839 67 P30536,P42785,Q13310,P04083,Q96AY3,Q96G23,Q16539,Q8WTV0,P38435,P10586,P45985,P58107,P09601,Q02750,P04792,P00374,Q9Y624,O14936,P42345 19 +Regulation of blood circulation 0.5020527625797349 1.6456755284055378 0.0998305798994632 1.0 0.5999472401831839 22 O75844,P78417 2 +Protein maturation 0.4057515524526101 1.6435284720641012 0.1002736394314236 1.0 0.6003843011324221 57 Q99829,Q8TCT9,Q86UY6,Q969M3,Q15392,Q9BU89,O75976,Q9UBS4,Q9NRN7,O75503,P62942,P42892,O75844,Q5JRX3,Q92896 15 +Ear development 0.5224083429721975 1.642197268816752 0.1005491285351058 1.0 0.6011130448367604 20 O60443,P54802,P42892,Q06124 4 +Positive regulation of immune effector process 0.4532044482754651 1.6416538766925577 0.1006617553779336 1.0 0.6011515195087596 34 O75179,Q96FZ2,P14174,P01889,Q06481,P09601,O96028,Q9NUQ9,P04439 9 +Cytochrome complex assembly 0.672416683567731 1.641251150681459 0.1007452917339912 1.0 0.6011515195087596 8 Q9Y2R0,Q6DKK2 2 +Negative regulation of protein metabolic process 0.3830328106431607 1.6403651028822293 0.1009292766814318 1.0 0.6016828093417059 255 P30536,P30086,Q15392,Q13363,Q9Y3I1,Q10713,O15212,P10644,Q9Y6M1,P07858,Q9NQP4,P46379,P51114,P10619,Q16850,Q9NY61,P16435,O15514,Q9Y2L1,Q9Y263,Q9UNH7,P04062,Q9HCE1,Q14011,Q32P28,P34897,Q06481,P19474,Q9H2J4,Q96FW1,P51116,O95197,O95684,Q969T7,Q9Y287,Q92945,O43765,O60506,Q96K76,Q9BPZ3,P67809,P00374,Q01105,Q9H074,Q9NQC3,Q96B26,O75718,P14174,P29375,P62942,Q8WXW3,Q12972,Q15750,Q96S97,Q9BWF3,Q92896,Q14103,Q06787,Q96PZ0,Q9H7B4,Q07954,Q96C86,Q9NVN8,Q9C0B1,P11940,Q92990,Q14671,P31483,P61758,P46109,Q53EL6,Q96ST3,Q96KB5,Q13501,P17931,P78318,Q92769,P30153,P04792,O94992,Q8IXJ6 81 +Connective tissue development 0.5008214019783542 1.6367794268360074 0.1016765659331477 1.0 0.6038794224603915 22 Q8N0X7,P43490,O15173,O75844,Q06124 5 +Positive regulation of viral life cycle 0.6889866997017686 1.6367681437274286 0.1016789243751361 1.0 0.6038794224603915 7 O60684,P19474 2 +Protein localization to microtubule organizing center 0.6529600567271262 1.635102220482176 0.1020276207758312 1.0 0.6048270757977032 9 Q15154,Q8WXW3,Q14789,Q96R06,Q15691,Q13561 6 +Calcium ion transport 0.4119296661648314 1.635093855035722 0.102029374156185 1.0 0.6048270757977032 53 P30536,P42858,P78417,P21796,P62942,O75844,O14936 7 +N terminal protein amino acid modification 0.6876766442642882 1.6307345879034525 0.1029463350015857 1.0 0.6085549672621727 7 P30419,Q86UY6 2 +Regulation of dephosphorylation 0.4594397792190926 1.62241041975913 0.1047154995913703 1.0 0.6138595013048234 30 P78318,Q12972,P17931,P42858,Q86XL3,Q92797,P62942,P04062,P42345 9 +Negative regulation of lipid transport 0.9181494661921754 1.6198839088193515 0.1052572170497296 1.0 0.6151748755039439 2 Q06124 1 +Response to nutrient 0.4605599694076623 1.618191811795225 0.1056212669422496 1.0 0.6151748755039439 29 P30536,P53985 2 +Glial cell migration 0.5931881379773174 1.6167555903061963 0.1059310490516525 1.0 0.6151748755039439 12 P30536,Q96N66,Q96G23,Q9NQC3 4 +Positive regulation of t cell mediated cytotoxicity 0.8881659121902041 1.616270249902212 0.1060358960534089 1.0 0.6151748755039439 4 Q9NUQ9,P04439 2 +Regulation of t cell mediated cytotoxicity 0.8881659121902041 1.616270249902212 0.1060358960534089 1.0 0.6151748755039439 4 Q9NUQ9,P04439 2 +Platelet derived growth factor receptor signaling pathway 0.6651272336440589 1.6064761396306808 0.1081693333948006 1.0 0.624288766596404 8 O14964,Q07954,Q06124 3 +Acute inflammatory response 0.7815732115609515 1.6056760180882577 0.108345113207589 1.0 0.624436965829364 5 P42785 1 +Lipopolysaccharide mediated signaling pathway 0.7177904707784997 1.6054623697819368 0.1083920881193467 1.0 0.624436965829364 6 P14174,Q8WTV0 2 +Positive regulation of neuron differentiation 0.6643006038234243 1.6025264381029476 0.1090392460151221 1.0 0.6258759932986224 8 Q99829,Q8WUJ1 2 +Establishment of protein localization to vacuole 0.5566049638919741 1.6013596136320354 0.1092972923645123 1.0 0.6258759932986224 15 O14964,Q14108,Q9Y2T2,Q92783 4 +Tetrapyrrole metabolic process 0.5162130101915773 1.5996542812515115 0.1096752994376635 1.0 0.6258759932986224 20 P30536,Q9H3L0,P30519 3 +Positive regulation of nitric oxide synthase activity 0.913167259786484 1.599415553352478 0.1097282986515337 1.0 0.6258759932986224 2 Q8WTV0 1 +Terpenoid metabolic process 0.5492343008991353 1.5964210857055452 0.1103948115535209 1.0 0.6272020863138501 16 Q9HB40,Q07954,P29375,P48449,P51648,Q9BY49 6 +Regulation of intrinsic apoptotic signaling pathway 0.4273255199424105 1.5962959753862227 0.1104227282310741 1.0 0.6272020863138501 46 O95881,Q07820,P16989,P45880,P61978,Q96K76,O60443 7 +Phosphatidic acid metabolic process 0.7778937036561058 1.59063983769981 0.1116906535862807 1.0 0.6313859694703488 5 Q9NPH0,Q8NF37 2 +Regulation of erad pathway 0.7139381051315831 1.5886004074994935 0.1121506361478517 1.0 0.6320260166876611 6 P46379 1 +Intracellular lipid transport 0.6433777271886609 1.5876657096722129 0.1123619508907529 1.0 0.6323602866738024 9 O15118,P23786,O43772 3 +Endocrine system development 0.6607707411163097 1.5856465818310184 0.1128195030914438 1.0 0.6332481763423202 8 P30536,P04083,P46109,Q02750 4 +Behavior 0.395751664283901 1.5832463693882244 0.1133653214387491 1.0 0.6346254787609127 66 P30536,P50897,P42858,Q9BPZ3,O15118,P54802,P04062,O75844,P53985,O00264,P17900 11 +Glucose import 0.586804517920675 1.581277865659739 0.1138145182797312 1.0 0.6365777602282937 12 P31751,Q9BZF1,Q06481,Q99523,Q06124 5 +Positive regulation of macroautophagy 0.5452232204963575 1.5714975827946198 0.116067115439552 1.0 0.6429716720710297 16 O15270,P21796,P09601 3 +Locomotory behavior 0.4584053853531507 1.571232233305512 0.1161287154843919 1.0 0.6429716720710297 26 O75844,O15118,P50897 3 +Peripheral nervous system axon regeneration 0.9719069849212169 1.5710329264451792 0.1161750008348754 1.0 0.6429716720710297 3 P30536 1 +Nuclear transcribed mrna catabolic process deadenylation dependent decay 0.4583756257261801 1.570994506048636 0.116183924931265 1.0 0.6429716720710297 26 Q14103,P67809,O60506,Q9H074,P11940,Q969T7,Q96B26,Q00839,O15514,Q9Y2L1,Q96C86 11 +Proteolysis 0.3358197620881905 1.5703638269567193 0.1163304929059905 1.0 0.6429716720710297 340 P30086,Q5VTR2,Q15392,Q9Y3I1,Q10713,P42785,O75477,O00231,P49721,O75503,Q9UIQ6,Q14258,Q9UJX2,Q9UBS8,P07858,Q9HB40,O95831,P28072,P46379,Q9BT78,Q9UHG3,O75844,Q9NQH7,Q13042,O76024,P10619,P52888,P61289,P28074,Q92820,P49327,P16435,Q92905,Q9Y263,P42892,P04062,O43633,P34897,O14773,P20618,Q99496,Q06481,P28070,P19474,O43292,P53634,P60900,Q16531,Q9H3G5,Q9H2J4,Q96FW1,Q9Y3B8,Q5JRX3,Q96FZ2,O14737,O43765,Q92783,Q99436,Q9NR28,Q9NXR7,Q96K76,Q16740,Q9Y679,Q15369,P38159,O75976,Q6P179,Q9UPU5,P09960,Q8TEY7,P25788,Q96A26,P49720,Q8TCT9,Q9UJX3,Q92896,Q06787,O75832,Q9H000,Q8N3C0,Q07954,Q9BYT8,Q96RU2,Q99829,P55786,Q9NZ08,Q92990,Q969M3,Q92542,Q9H8M7,Q96KB5,Q13501,P78318,Q9UJX4,Q92769,P40818,Q9UL46,Q8IXJ6 98 +Lipid export from cell 0.9060498220640626 1.57015877769966 0.1163781770341598 1.0 0.6429716720710297 2 Q06124 1 +Astrocyte development 0.7714774730012004 1.564384561036344 0.1177272842232262 1.0 0.6468049321470641 5 Q07954,P15260 2 +Organic cation transport 0.8742673210793952 1.5633965151541571 0.1179593593252081 1.0 0.6471934718994322 4 Q70HW3 1 +Sensory perception of mechanical stimulus 0.5559698752686113 1.562535314577455 0.1181619332542416 1.0 0.6472096066518082 14 O60443,Q14108 2 +Carbohydrate transmembrane transport 0.5700034394859583 1.562174223998462 0.1182469511081847 1.0 0.6472096066518082 13 P31751,Q9BZF1,Q06481,Q99523,Q06124 5 +Sphingosine biosynthetic process 0.8739222233948127 1.5620819024666794 0.1182686956766283 1.0 0.6472096066518082 4 P04062 1 +Arachidonic acid secretion 0.9032028469750892 1.558451439995035 0.119126270741344 1.0 0.6507786014550839 2 P14174 1 +Synaptonemal complex organization 0.7065758068013918 1.5563169458102697 0.1196327438033053 1.0 0.6514660293494797 6 Q92791,P46379 2 +Protein localization to lysosome 0.5688841921714041 1.555736630107046 0.1197707324285826 1.0 0.6514660293494797 13 O14964,Q9NQC3,Q9Y2T2,Q14108 4 +Positive regulation of mrna metabolic process 0.395814626630657 1.5535988193077088 0.1202801411296972 1.0 0.6514660293494797 62 Q14103,P67809,O60506,Q9H074,P11940,Q96B26,Q969T7,P38159,Q92945,Q96C86,P62995,Q14011,P98179,Q9C0B1 14 +Homologous chromosome pairing at meiosis 0.6529914975850135 1.5483683999220543 0.1215336248287632 1.0 0.6519686100886227 8 Q92791,O60216,P46379 3 +Inflammatory response 0.3962047201389354 1.547699924680368 0.1216945602460692 1.0 0.6519686100886227 60 P14174,P42785,Q9UKG1,P04083,Q9BQE5,Q16539,Q15942,O60684,Q06330,Q53EL6,Q8IV08,P49327,P09601,Q9Y263,Q9UNH7,P04062,Q96KB5,Q9Y624,Q9H000,Q99496,Q06481,P28070,P53634,P60900,P42345 25 +Positive regulation of adaptive immune response 0.5476131479523207 1.5467497232368037 0.1219236079692085 1.0 0.6519686100886227 15 Q9NUQ9,Q96FZ2,O96028,P04439 4 +Anatomical structure maturation 0.4531678688875403 1.5462714745970505 0.1220390180734243 1.0 0.6519686100886227 28 Q8N2A8,O75179,P18074,P30153,Q08J23,O75503,P04062,Q8IXJ6 8 +Regulation of endothelial cell migration 0.4558495257162717 1.5446421219754658 0.1224328516767436 1.0 0.6523096503340603 25 Q13685,Q8WTV0,P09601,P42785 4 +Cell recognition 0.5176462651169795 1.5431497101342262 0.1227944558796856 1.0 0.6528091165348723 19 Q9NQC3,Q8WTV0,Q5KU26,P45880,P17931 5 +Regulation of protein acetylation 0.4874948555870911 1.5401373291192226 0.1235268822935782 1.0 0.6550542703718872 22 Q01105,Q96ST2,Q92769,Q969T9,Q96ST3,Q03164,O75844,Q7L7X3 8 +Tetrapyrrole catabolic process 0.765163083364781 1.5385035743289708 0.1239255352560217 1.0 0.6556732022664954 5 P30519 1 +Embryonic brain development 0.7642998147548314 1.5349621103391622 0.1247931353797833 1.0 0.6595613835710482 5 Q9BVA1,P62995 2 +Negative regulation of cellular amide metabolic process 0.3692254168764258 1.5339198684662236 0.1250493674230142 1.0 0.6599003000096881 83 Q9H074,Q9NQC3,Q96B26,P51116,Q10713,O95197,Q9Y6M1,Q9C0B1,P11940,Q969T7,Q13131,Q92945,Q14671,P31483,P51114,O60506,P49458,Q00839,Q12906,O00425,O15514,Q7Z739,Q9Y2L1,Q9HCE1,Q9BPZ3,Q9BWF3,Q14011,Q14103,P34897,P67809,Q06787,Q6PKG0,Q96PZ0,P00374,Q96C86 35 +Cellular response to osmotic stress 0.5899090548970226 1.5290795880256531 0.1262447148933843 1.0 0.662523736043982 11 P30536 1 +Molting cycle 0.5641730333037362 1.5286076733081362 0.1263617326304644 1.0 0.662523736043982 13 O75844,P18074,Q08J23,Q92769 4 +Regulation of defense response to virus 0.5641257695047281 1.5283352519256694 0.1264293216957097 1.0 0.662523736043982 13 O75844,O43657 2 +Protein k63 linked ubiquitination 0.5629732590497464 1.5216908134488485 0.128086570526269 1.0 0.662523736043982 13 P19474 1 +Negative regulation of cellular catabolic process 0.3682884408829615 1.5214300172372794 0.1281519608901322 1.0 0.662523736043982 83 P30536,Q9H2J4,Q9H074,P16989,P35637,Q08J23,P46379,Q92804,O43765,O60506,P10619,P09601,O15118,Q99729,Q14011,Q14103,P67809,P98175,Q07820 19 +Negative regulation of autophagy 0.4848191936936981 1.5206576996320058 0.1283457590765835 1.0 0.662523736043982 22 P30536,P10619,P09601 3 +Regulation of necrotic cell death 0.5626864300981121 1.5200367323466544 0.1285017439815909 1.0 0.662523736043982 13 P30536 1 +Protein insertion into er membrane 0.5878842461992241 1.5180953804457975 0.1289903555700964 1.0 0.662523736043982 11 O43765,P46379 2 +Regulation of cytoplasmic translation 0.5360704721326078 1.514466268904065 0.1299076226956332 1.0 0.662523736043982 16 Q14103,P67809,O60506,Q06787,Q9H074,P11940,P16989 7 +Regulation of ossification 0.6079794478764756 1.5125823283843245 0.130385785763424 1.0 0.6630888617198814 10 O75844 1 +Negative regulation of exocytosis 0.6620531012567178 1.5121482647082558 0.1304961488265528 1.0 0.6630888617198814 7 P04083,P09601 2 +Homologous chromosome segregation 0.6279609232136797 1.5109788013771197 0.1307938519603266 1.0 0.6630888617198814 9 Q92791,O60216,P46379 3 +Aminoglycan metabolic process 0.5469624985303287 1.5089034987495231 0.1313234456055603 1.0 0.6647258699348443 14 P16278,P04066,O43505,P54802,P08236,P06865 6 +Response to misfolded protein 0.6440741375240723 1.5055102326632943 0.1321929480744783 1.0 0.6658579785344119 8 P46379 1 +Sterol homeostasis 0.5853547274143055 1.5043613845057242 0.1324883414487725 1.0 0.6658579785344119 11 Q8WTV0,Q5BJF2 2 +Regulation of ryanodine sensitive calcium release channel activity 0.7559862929155969 1.5008196157991192 0.1334022236817182 1.0 0.6677487294400068 5 P78417 1 +Positive regulation of pattern recognition receptor signaling pathway 0.6425030743288795 1.4979460908415072 0.1341472573202207 1.0 0.6698905986116931 8 Q9NUD5,O75179,Q9NQC3 3 +Protein processing 0.4339192207474868 1.4941530740605815 0.1351356145281246 1.0 0.6716505013840985 35 Q99829,Q8TCT9,Q969M3,Q15392,O75976,O75503,P42892,O75844,Q5JRX3,Q92896 10 +Phosphatidylcholine metabolic process 0.5831976532683016 1.4926393846839607 0.1355316080536521 1.0 0.6718002597774475 11 Q8NCC3,Q8WTV0,Q8NF37,P35790 4 +Negative regulation of developmental process 0.3517389590434238 1.4915920601482802 0.1358061209301941 1.0 0.6718002597774475 90 P30536,Q9NQC3,P16989,P14174,P04083,Q96G23,Q8N4Q0,Q96FV9,Q53EL6,O75179,Q99873,Q8N0X7,Q4VCS5,Q99523,Q86X55,Q06124,P67809,Q92769,O14964,Q06481,Q9UBS4,Q8IXJ6 22 +Positive regulation of response to endoplasmic reticulum stress 0.6575688942487852 1.491289632320845 0.1358854697374261 1.0 0.6718002597774475 7 P46379 1 +Glycolipid biosynthetic process 0.6407965004041751 1.4897251100869928 0.1362965294272318 1.0 0.6726722016981058 8 Q8NBX0,Q99805,Q13131,O43292,O60762 5 +Bone remodeling 0.640414772940358 1.487885615411024 0.1367810618237908 1.0 0.6733718385297206 8 O14773 1 +Regulation of calcium ion import 0.854241285471848 1.4869835041645163 0.1370191677753567 1.0 0.6736155672555745 4 P21796 1 +Phospholipid transport 0.5431335169040743 1.4860485804991648 0.1372662716032087 1.0 0.6738510468481208 14 P08183,Q9BZF1,Q8WTV0,Q14108 4 +Regulation of adaptive immune response 0.5088241852526585 1.483622625862952 0.1379090634493442 1.0 0.6758930665726951 19 Q5RKV6,Q96FZ2,P01889,P04083,O96028,Q9NUQ9,P04439 7 +Skin epidermis development 0.5690099007625704 1.4818972376157094 0.1383676401957143 1.0 0.6761780060373164 12 O75844,P18074,Q08J23,Q92769 4 +Regulation of glial cell proliferation 0.947558538218834 1.4818434232119655 0.1383819619544157 1.0 0.6761780060373164 3 P30536 1 +Regulation of immune effector process 0.425053074370249 1.4812067192124496 0.1385514962546921 1.0 0.6761780060373164 41 Q01650,O75179,Q5RKV6,P14174,Q96FV9,P01889,Q96FZ2,Q06481,P09601,Q9UKG1,P04083,O96028,Q9NUQ9,P04439 14 +Regulation of pinocytosis 0.7509739636578561 1.4802035359583867 0.1388189370824299 1.0 0.6761780060373164 5 P50897,Q06481 2 +Positive regulation of pinocytosis 0.7509739636578561 1.4802035359583867 0.1388189370824299 1.0 0.6761780060373164 5 P50897,Q06481 2 +Regulation of response to wounding 0.5234191864284802 1.4776377478087557 0.1395047650510927 1.0 0.6781909901246901 17 O14936,Q02750,P04083,Q96G23,P42345,P10586 6 +Ribonucleoside metabolic process 0.6205319091438447 1.4738743732370392 0.1405154188173014 1.0 0.6801174777011371 9 Q13126 1 +Negative regulation of leukocyte mediated immunity 0.8497150997150917 1.4696810656979995 0.1416481531636284 1.0 0.6826040658539266 4 P04439,P01889,P09601 3 +Cellular transition metal ion homeostasis 0.5145347629550565 1.4679534705060484 0.1421168622850066 1.0 0.6836178685692327 18 Q9Y487,Q8N511,P09601 3 +Regulation of attachment of spindle microtubules to kinetochore 0.652337655209156 1.466919648287006 0.142397914866875 1.0 0.6836178685692327 7 Q8IXJ6,Q96R06 2 +Gdp metabolic process 0.8804270462633526 1.4647332492066372 0.1429937097793254 1.0 0.6844539930259631 2 O14936 1 +Cardiac cell development 0.5987807747225488 1.4646951213690045 0.1430041165798288 1.0 0.6844539930259631 10 O75844,Q53EL6,P42345 3 +Lipophagy 0.7468590284262577 1.4632620351186283 0.1433956918355807 1.0 0.6845142201054701 5 Q9Y679,O15270 2 +Regulation of mitochondrial membrane permeability 0.5518525182142182 1.457431333682112 0.1449973530354642 1.0 0.6845142201054701 13 P45880 1 +Triglyceride metabolic process 0.6501492471606322 1.4567135856575983 0.1451954580292436 1.0 0.6845142201054701 7 Q8WTV0 1 +Monocarboxylic acid transport 0.6498091888052331 1.45512707614615 0.14563408457854 1.0 0.6845142201054701 7 P14174,P53985 2 +Protein k48 linked deubiquitination 0.5969344908710771 1.4550654792570203 0.1456511348721987 1.0 0.6845142201054701 10 Q96FW1,Q8TEY7,P40818,Q99496,Q9H8M7 5 +Regulation of filopodium assembly 0.6335766117178268 1.4548959392261585 0.1456980722011704 1.0 0.6845142201054701 8 P51116,P51114,Q06787 3 +Detection of external biotic stimulus 0.9401922392310414 1.4548269822850906 0.1457171663124947 1.0 0.6845142201054701 3 Q8WTV0,P04439 2 +Negative regulation of secretion 0.504260374848001 1.4527449967005233 0.146294568653813 1.0 0.6862092387558945 19 Q06787,Q16850,P09601,P04083,Q06124 5 +Adaptive immune response 0.4260973297397698 1.4520366531334177 0.1464914139962541 1.0 0.6864123897708837 38 Q5RKV6,Q96FW1,P04083,O96028,Q6P179,P04439,P02786,Q96FV9,P01889,Q96FZ2,Q9NZ08,Q12888,P10321,Q9NUQ9,P52701,Q9UQ84,P53634,P42345,P13051 19 +Regulation of binding 0.3697626311090647 1.4518097386947433 0.1465545152848359 1.0 0.6864123897708837 79 Q99829,Q9NVN8,P62136,O60869,O75503,P40855,Q8TEY7,P18074,Q92797,P62942,O75844,P30533,P10586,P09601,Q86X55,Q96ST3,P35269,Q06787,Q9Y2S7,Q92769,P19474,Q8IXJ6,Q07954 23 +Tail anchored membrane protein insertion into er membrane 0.6322659502432776 1.448564953454028 0.1474591144256487 1.0 0.6881063388183624 8 P46379 1 +Negative regulation of nitric oxide metabolic process 0.938056247775016 1.4469911327412424 0.1478994070875341 1.0 0.6889282278291791 3 P30536,P06280 2 +Necrotic cell death 0.5034083202336507 1.446974290298487 0.1479041243621393 1.0 0.6889282278291791 19 P30536,O60443 2 +Ion transmembrane transport 0.3664777922107558 1.4449344402454318 0.1484763013735284 1.0 0.6892998694535162 138 Q70HW3,P21796,Q9C0H2,P45880,Q96ES6,P36543,O75964,P53985,P62942,Q9UHG3,O75844,Q6P4Q7,Q9UBX3,Q9Y4C2,Q9H2D1,O43865,P78417,O43772,Q9Y619,P08183,Q9HD20,P42858,P47985 23 +Regulation of lymphocyte mediated immunity 0.5030466510782009 1.444524268300241 0.1485915582852608 1.0 0.6893299449880659 19 Q5RKV6,Q96FZ2,P01889,O96028,Q9NUQ9,P04439 6 +Axon development 0.3829564372360286 1.4422237430346283 0.149239264601751 1.0 0.6894080705744152 67 P30536,Q9BVA1,Q96ST3,Q9NQC3,Q8TEY7,Q9UJX6,Q8N0X7,Q02750,Q12955,Q06481,P00374,Q9UQB8,O75312,P42892,Q96G23,O00264,Q06124 17 +Negative regulation of catabolic process 0.3443137633398214 1.442177704273091 0.1492522486411882 1.0 0.6894080705744152 93 P30536,Q9H2J4,Q9H074,P16989,P35637,Q08J23,P46379,Q92804,O43765,O60506,P10619,Q16850,P09601,O15118,Q99729,Q14011,Q14103,P67809,P98175,Q07820 20 +Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 0.5489750471560242 1.440763414571724 0.1496515325666867 1.0 0.6894080705744152 13 P46379 1 +Carbohydrate derivative transport 0.5487855012791296 1.4396649014355758 0.1499622280070498 1.0 0.6894080705744152 13 P07602,Q8WTV0,Q8TB61 3 +Organic hydroxy compound metabolic process 0.3476856141268271 1.4391673790259634 0.1501031053841528 1.0 0.6894080705744152 99 Q9BY49,Q14739,Q16850,Q8WTV0,O75874,Q15392,Q14914,O15270,P48449,O15118,P00374,P04062,Q15800,P48735,Q9BQE5,P07858 16 +Regulation of neuronal action potential 0.8740213523131765 1.4383680929791425 0.1503296407933021 1.0 0.6894080705744152 2 P04062 1 +Regulation of transmission of nerve impulse 0.8740213523131765 1.4383680929791425 0.1503296407933021 1.0 0.6894080705744152 2 P04062 1 +Regulation of protein folding 0.9355334422182888 1.4377353460100604 0.1505091601251673 1.0 0.6894080705744152 3 Q9H2J4 1 +Modified amino acid transport 0.8413581119744504 1.4377085652017103 0.1505167618255833 1.0 0.6894080705744152 4 Q9H2D1 1 +Oligosaccharide metabolic process 0.6455845304439256 1.4354045775341575 0.1511718423462738 1.0 0.6901844127869863 7 P10253,P06280,P17900 3 +Protein o linked glycosylation 0.5605055019898659 1.4341712980898744 0.151523385550083 1.0 0.6912913565377079 12 O60502 1 +Xenobiotic catabolic process 0.7393820193912437 1.4324430411370113 0.1520170680980768 1.0 0.6924531787413452 5 P78417 1 +Negative regulation of cellular macromolecule biosynthetic process 0.3454278931095481 1.4319385807815432 0.1521613995860549 1.0 0.6924531787413452 96 Q9H074,Q9NVN8,Q96B26,P51116,Q10713,Q9Y6M1,Q9C0B1,P11940,Q969T7,Q9Y287,Q92945,Q14671,P31483,P51114,O60506,P49458,Q00839,Q9NY61,Q12906,O00425,O15514,Q7Z739,Q9Y2L1,Q9HCE1,Q9UIV1,Q9BPZ3,Q99543,Q9BWF3,Q14011,Q14103,P34897,P67809,Q06787,Q6PKG0,Q8ND56,Q96PZ0,P00374,Q96C86,O14734 39 +Negative regulation of blood pressure 0.8396902190086988 1.431323825395602 0.1523374286566619 1.0 0.6924531787413452 4 P42785 1 +Organic anion transport 0.4181115342434631 1.4309879357275148 0.1524336727701083 1.0 0.6924531787413452 42 Q8TB61,P07602,P14174,Q9Y619,P04083,P53985,Q9UBX3,Q9H2D1,Q7L0J3 9 +Glutathione metabolic process 0.5160072324090236 1.430041928920426 0.1527049854524826 1.0 0.693188748432939 17 P78417,Q9H7Z7,O75874 3 +Regulation of calcium ion transmembrane transport 0.4820675639565117 1.4291838208830645 0.1529514066366255 1.0 0.693314065705505 21 P78417,P62942,P21796,P42858 4 +Sterol transport 0.4717797040093128 1.4253988997739626 0.1540419259274985 1.0 0.6968909246151538 22 P30536,Q8WTV0 2 +Folic acid containing compound metabolic process 0.5586569880208325 1.4237797709716418 0.1545102333096573 1.0 0.6968909246151538 12 P00374,Q9H2D1,Q92820 3 +Striated muscle cell proliferation 0.7370977110937078 1.4230188937158477 0.1547306782354396 1.0 0.6968909246151538 5 Q16539,P52294,P10644 3 +Lipid metabolic process 0.374627953424943 1.4213729491247236 0.1552083662648433 1.0 0.6968909246151538 237 P30536,Q99829,P07099,O75874,P14174,Q15392,Q14914,P42126,P29375,P04066,O76054,P48449,P21964,P04083,O15254,O60869,Q96N66,P06865,Q15800,Q9BY49,P53985,Q96G23,Q8N4Q0,Q9BQE5,P09960,P16278,P61916,Q86UY6,Q8N2A8,Q9HB40,Q8WTV0,Q8NF37,Q9UKR5,P49356,Q9BZF1,P06280,Q9NPH0,P51648,Q709F0,Q9BWD1,O75844,P37268,Q8NBJ4,P46109,Q8NHP8,Q8WXW3,P50897,Q16850,Q96PU8,Q15067,O15270,O15118,Q8NCC3,P04062,P35790,Q06124,Q14739,O14773,P07602,Q9Y217,P31751,Q16836,Q07954,Q06481,Q06136,Q99943,Q8NBX0,P42356,P23786,Q9H7Z7,P17900 71 +Regulation of lysosomal protein catabolic process 0.8370796314272027 1.4213282133116347 0.1552213651588649 1.0 0.6968909246151538 4 Q8NHS3,P04062 2 +Regulation of protein catabolic process in the vacuole 0.8370796314272027 1.4213282133116347 0.1552213651588649 1.0 0.6968909246151538 4 Q8NHS3,P04062 2 +Negative regulation of lymphocyte activation 0.5210311181593958 1.4203179027597288 0.1555151514638524 1.0 0.6968909246151538 16 Q8WXW3,Q96FV9,Q9Y3I1,Q96IZ0,Q92990,P04083,P17931 7 +Tor signaling 0.520041312148784 1.414104420324372 0.1573312454781958 1.0 0.7026131801235569 16 O75844,Q8NHS3,P04062 3 +Negative regulation of apoptotic signaling pathway 0.3849034416966322 1.4111804468970433 0.1581914140746616 1.0 0.7036593722220001 56 O76024,O95881,O75832,P61289,Q07820,P16989,P42858,P14174,Q14247,P04792,P09601,P45880,Q96K76,P17931 14 +Response to estrogen 0.5883712116208671 1.41032796744686 0.1584428640499453 1.0 0.7036593722220001 10 P21266,P04062,P09601 3 +Negative regulation of cell differentiation 0.378416697960769 1.4080503111056517 0.1591161728853951 1.0 0.7036593722220001 69 P30536,Q9NQC3,Q9Y3I1,O43707,P04083,Q96G23,Q8N4Q0,Q15154,Q15022,Q9NYV4,Q06330,Q53EL6,Q8WX92,O75179,Q99873,Q00839,Q8N0X7,Q99523,Q92688,Q9P265,Q06124,P67809,Q06481,Q9UBS4,Q8IXJ6 25 +Regulation of cell aging 0.5558511476780053 1.407995070885753 0.1591325295593599 1.0 0.7036593722220001 12 O75844,P67809,P14174 3 +Positive regulation of autophagy of mitochondrion 0.6727717121894593 1.4072026374369304 0.1593673098003474 1.0 0.7036593722220001 6 P21796 1 +Negative regulation of neuron apoptotic process 0.4692795430545587 1.4070772148450237 0.1594044937063321 1.0 0.7036593722220001 22 Q01105,P50897,P45985,P09601,P04062 5 +Astrocyte activation 0.8661921708185136 1.4061489684255395 0.1596798940195136 1.0 0.7036593722220001 2 P15260 1 +Camera type eye morphogenesis 0.6722320254438925 1.4048116332003835 0.1600772988785417 1.0 0.7036593722220001 6 P54802 1 +Antigen processing and presentation of exogenous peptide antigen 0.9263192864785056 1.4039239143863274 0.1603415075727581 1.0 0.7036593722220001 3 Q9UIQ6 1 +Regulation of er to golgi vesicle mediated transport 0.7318822484917897 1.4014879578553503 0.161068206091449 1.0 0.7058708312596904 5 Q9P2W9 1 +Positive regulation of chemokine production 0.7313837326464759 1.399428963967174 0.1616843863852608 1.0 0.7075925114111864 5 P09601 1 +Cellular response to arsenic containing substance 0.6367412679079474 1.394047589516248 0.1633032342531257 1.0 0.7119934358481254 7 P78417 1 +Cytosolic calcium ion transport 0.477016544025281 1.39313115958972 0.1635801320889889 1.0 0.7119934358481254 21 P78417,P21796,P42858 3 +Skin development 0.4269000410932764 1.39300429316838 0.1636184924451742 1.0 0.7119934358481254 33 Q92769,Q15392,P18074,Q02750,P04083,Q08J23,P04062,O75844 8 +Protein targeting to lysosome 0.5641420132723007 1.3887097045675978 0.1649210419937667 1.0 0.7119934358481254 11 O14964,Q14108,Q9Y2T2 3 +Adult locomotory behavior 0.5264961866669784 1.386393251629174 0.1656268559543794 1.0 0.7119934358481254 14 O75844,P50897 2 +Tumor necrosis factor superfamily cytokine production 0.5155802216236925 1.3860763907320086 0.1657235786454134 1.0 0.7119934358481254 16 P30536,P15260,O43823,Q06124 4 +Prostate gland development 0.6677602111171915 1.3849891592214412 0.1660557822351374 1.0 0.7129315612201916 6 P07602 1 +Protein localization to microtubule 0.6345046113661554 1.383572785044155 0.1664893063001091 1.0 0.7130590353301778 7 O15344,P29372,Q15691,Q15555 4 +Glycosylation 0.4195750456781622 1.3824129826937614 0.16684493205304 1.0 0.7130590353301778 37 O60502,O15118,O75503,O43505 4 +Regulation of response to endoplasmic reticulum stress 0.4848159552253 1.382232471495359 0.1669003328181624 1.0 0.7130590353301778 20 O95881,P46379 2 +Filopodium assembly 0.6017151607954551 1.379504169973822 0.1677393614317437 1.0 0.7130590353301778 9 P51116,P51114,Q06787 3 +Fucose metabolic process 0.8594306049822151 1.378332726868318 0.1681005832940041 1.0 0.7130590353301778 2 Q9BTY2 1 +Alcohol metabolic process 0.3707939060194279 1.378303681882513 0.1681095469123064 1.0 0.7130590353301778 74 Q14739,Q8WTV0,O75874,Q16850,Q15392,O15270,P48449,O15118,P04062,Q15800,Q9BY49,Q9BQE5,P48735 13 +Tissue regeneration 0.6644143008773924 1.3701455106788745 0.1706414836463561 1.0 0.7218658757456333 6 P04083,P52294,P58107 3 +Regulation of triglyceride metabolic process 0.856583629893251 1.3666244250608672 0.1717430572917198 1.0 0.7222109575335015 2 Q8WTV0 1 +Phosphatidylcholine acyl chain remodeling 0.8565836298932368 1.3666244250608084 0.1717430572917382 1.0 0.7222109575335015 2 Q8NF37 1 +Programmed cell death 0.3074325925292145 1.36625333818565 0.1718594613318742 1.0 0.7222109575335015 365 P30536,Q9NS69,Q15392,P21796,P45880,O43813,Q03164,P07858,Q16539,Q13564,Q07157,P27635,P18074,P52294,O95831,O95470,P46379,Q14247,O75844,P51114,O76024,O95881,P50897,P61289,Q8IXM3,Q9NY61,Q96KA5,P49327,P09601,P16435,Q92905,Q9UNH7,P04062,O60443,Q8IYB8,P30419,O00429,Q86XL3,Q9H2J4,P16989,O95197,O14737,P30154,Q9NR28,Q9NXR7,P61978,Q96K76,Q7L7X3,P98175,Q07820,P42858,P31751,Q9Y6C9,Q01105,O75940,Q9NQC3,P14174,P04083,P39687,Q96A26,Q9UHX1,P45985,P11717,O43865,Q99523,O75832,Q96IZ0,Q96C86,Q96RU2,P62136,O60216,O75312,O00471,Q96FV9,Q9BZZ5,P31483,P46109,Q53EL6,Q92542,P52756,Q9H8M7,Q96ST3,Q8WYA6,Q13501,P17931,P78318,Q92769,P30153,P21127,P04792,Q8IXJ6,Q01085,P42345,P13051 94 +Negative regulation of nik nf kappab signaling 0.8225856370360289 1.3657913110031374 0.1720044744031912 1.0 0.7222109575335015 4 Q9H000,O43657 2 +Regulation of motor neuron apoptotic process 0.8555160142348748 1.362234509162248 0.1731238883351533 1.0 0.7222423175640993 2 P45985 1 +Positive regulation of mrna processing 0.4723996932203125 1.360123506224502 0.1737908436835202 1.0 0.7234525130908749 21 P62995,Q14011,P98179 3 +Chemokine production 0.6620996941262896 1.3598713798991875 0.1738706292310876 1.0 0.7234525130908749 6 P09601 1 +Positive regulation of t cell mediated immunity 0.7216719227287505 1.3592858691870893 0.1740560200478409 1.0 0.7235643231118647 5 Q9NUQ9,P04439 2 +Xenobiotic metabolic process 0.5583309986667511 1.3568951010593533 0.174814543677324 1.0 0.7254746321435512 11 P78417,P07099,O43169 3 +Regulation of mrna splicing via spliceosome 0.3763977196833588 1.3562158141067877 0.1750305118304533 1.0 0.7258955192863763 66 Q06787,P51114,P98175,Q96PU8,P51116,P98179,Q4G0J3,P38159,Q13242,P61978,P62995,Q14011,P31483,Q9UHX1,Q9BWF3,P22626,Q07666,O75525 18 +Phosphatidylethanolamine metabolic process 0.9130824552868928 1.3553465509198763 0.1753071701683095 1.0 0.7263209573645989 3 Q8NCC3 1 +Positive regulation of membrane permeability 0.5776392288571437 1.3541022181220603 0.1757037686477605 1.0 0.7267783069127065 10 P45880 1 +Multicellular organism reproduction 0.3458209363155405 1.3539226698464395 0.1757610501595898 1.0 0.7267783069127065 106 P16989,O75718,P04083,Q08J23,Q9BQE5,P07858,Q9P0K7,Q8N2A8,P46379,Q99417,Q14671,O60684,P46109,Q07666,Q8NI77,Q96PU8,P11717,Q15067,Q4G0J3,Q9BPZ3,Q9BW83,Q06124,Q9BTX1,Q92769,Q8NB78,P30153,P35613,Q8IXJ6,Q01085 29 +Neuronal action potential 0.8194444444444441 1.353747923491418 0.1758168130814548 1.0 0.7267783069127065 4 Q06787,Q12955,P04062 3 +Regulation of lipid transport 0.515592951776685 1.350779638804894 0.1767660323299211 1.0 0.729123893119173 15 P30536,P31751,P14174,O15260,Q06124 5 +Negative regulation of cell killing 0.9114595480077372 1.349391317417335 0.17721130817906 1.0 0.7298900684948861 3 P04439 1 +Regulation of natural killer cell mediated immunity 0.8177109177641354 1.3471007537560795 0.1779477854293207 1.0 0.7309691973665793 4 P04439 1 +Cell maturation 0.4606648830221963 1.3438255194566888 0.1790048152212573 1.0 0.7335449419002552 22 O75503,P04062 2 +Regulation of neuron projection regeneration 0.7178831088983794 1.3436106328295108 0.179074329354536 1.0 0.7335449419002552 5 Q96G23,Q02750 2 +Regulation of leukocyte mediated immunity 0.4299100695530714 1.342051852879975 0.1795791834996007 1.0 0.7348467353941718 26 Q96FZ2,P09601,O96028,Q9NUQ9,P04439 5 +Negative regulation of amyloid fibril formation 0.7171276993492666 1.340484459593548 0.1800878933355134 1.0 0.7348467353941718 5 P61758,O15212,Q9NQP4 3 +Regulation of amyloid fibril formation 0.7171276993492666 1.340484459593548 0.1800878933355134 1.0 0.7348467353941718 5 P61758,O15212,Q9NQP4 3 +Icosanoid metabolic process 0.4948598327071662 1.337969006139899 0.1809065404370156 1.0 0.736763976060005 18 P07099,P14174,Q14914,P04083,Q8N4Q0,Q9H7Z7,P09960 7 +Response to epidermal growth factor 0.5432858660681656 1.3371508529330347 0.1811734006569132 1.0 0.737376904279293 12 Q9UQB8 1 +Negative regulation of production of molecular mediator of immune response 0.8491103202847095 1.335904338027348 0.181580542874125 1.0 0.7374165429714795 2 P09601 1 +Natural killer cell activation 0.6089648447782621 1.3356336423137196 0.1816690483668075 1.0 0.7374165429714795 8 P46379 1 +Actin cytoskeleton reorganization 0.4869475186542878 1.3351658706278693 0.1818220644027279 1.0 0.7374165429714795 19 Q07157,P11233,P04083,Q9UQB8,P62993,Q9Y624 6 +Detection of light stimulus 0.8144587953108285 1.3346292872842922 0.1819977076230698 1.0 0.7374165429714795 4 P30419,Q15555 2 +Phototransduction 0.8144587953108285 1.3346292872842922 0.1819977076230698 1.0 0.7374165429714795 4 P30419,Q15555 2 +Regulation of t cell mediated immunity 0.6556523561486592 1.3312298673565484 0.1831133866361169 1.0 0.7391833085795585 6 Q9NUQ9,P04439 2 +Regulation of membrane permeability 0.506632155224351 1.3297513511892056 0.1836002095162103 1.0 0.7391833085795585 16 P45880,P30419 2 +Regulation of fat cell differentiation 0.5290608492471575 1.3250141280966108 0.1851664654404405 1.0 0.7431284936643902 13 Q16539,Q99523,Q86X55,Q8IXJ6,Q8N4Q0,Q9C0B1,Q96A49 7 +Calcium mediated signaling 0.5113322285810135 1.32455993750529 0.1853171509922724 1.0 0.7432625226822976 15 O75844,P78417 2 +Steroid biosynthetic process 0.4030532568679513 1.3191214011325765 0.1871285295079723 1.0 0.7456982936083566 44 P30536,Q16850,Q15392,P48449,Q15800 5 +Skeletal muscle tissue regeneration 0.7115879263967452 1.317550814927982 0.1876540598267284 1.0 0.7458327910871582 5 P52294 1 +Positive regulation of transporter activity 0.4567314212979744 1.314888783793363 0.1885472828344054 1.0 0.7458327910871582 22 Q03164,P78417,P08183,Q9Y4C2 4 +Aorta development 0.6192321644850525 1.3119082692051771 0.1895510870895032 1.0 0.7483567715279437 7 Q96AY3,Q15750,Q07954 3 +Regulation of glial cell migration 0.8427046263345338 1.3095933381570926 0.1903334433041248 1.0 0.7483567715279437 2 Q96G23 1 +T cell extravasation 0.8427046263345228 1.3095933381570466 0.1903334433041403 1.0 0.7483567715279437 2 Q9Y624 1 +Positive regulation of cell death 0.3427876163693817 1.3091475553841738 0.1904843731220724 1.0 0.7483567715279437 106 P30536,Q9NS69,P62136,P04083,Q96A26,O14737,Q53EL6,P30154,P45985,P11717,Q9NR28,P09601,P52756,O60443,Q8WYA6,Q13501,P98175,Q07820,P42858,Q96IZ0,P30153,Q9Y6C9,Q07954 23 +Positive regulation of erad pathway 0.8071877064863331 1.306741476014805 0.1913005272952288 1.0 0.7488896824029689 4 P46379 1 +Dna templated transcription termination 0.6174442769057384 1.3035045133095564 0.1924025765354271 1.0 0.7507381638102498 7 O75844 1 +Collagen fibril organization 0.6171668240782489 1.3022001412669282 0.1928479769181019 1.0 0.7511233126797862 7 Q92791,P13674,O75718 3 +Histone h3 k36 trimethylation 0.8391459074733085 1.2949860807828184 0.1953250312092203 1.0 0.7565860163648098 2 Q9BYW2 1 +Positive regulation of anion transport 0.6145295672935709 1.289798697125486 0.1971205604374675 1.0 0.760237902308638 7 P08183,Q9Y4C2 2 +Positive regulation of amyloid precursor protein biosynthetic process 0.8377224199288249 1.289145412903837 0.1973475381564935 1.0 0.760237902308638 2 Q96IZ0 1 +Glutamate receptor signaling pathway 0.8377224199288246 1.2891454129038362 0.1973475381564939 1.0 0.760237902308638 2 Q06787 1 +Membrane protein intracellular domain proteolysis 0.8377224199288238 1.2891454129038329 0.197347538156495 1.0 0.760237902308638 2 Q8TCT9 1 +Negative regulation of innate immune response 0.5346666555103311 1.288427392649483 0.1975972284299527 1.0 0.7605951648200314 12 P19474,P04439 2 +Cellular ion homeostasis 0.3555245569004661 1.286364792878426 0.198315779588557 1.0 0.7609498517363571 80 Q9HD20,P50897,P42858,Q9Y487,P78417,Q93050,P09601,Q15904,O75503,Q8N511,Q7L0J3 11 +Positive regulation of cell migration involved in sprouting angiogenesis 0.8940438644368817 1.2855130060812583 0.1986130747628112 1.0 0.7609498517363571 3 P09601 1 +Regulation of cell migration involved in sprouting angiogenesis 0.8940438644368817 1.2855130060812583 0.1986130747628112 1.0 0.7609498517363571 3 P09601 1 +Negative regulation of lipid localization 0.893912424350303 1.2850311856909131 0.1987813865076493 1.0 0.7611345294857846 3 Q06124,P31751 2 +Adipose tissue development 0.5642109918565905 1.2835407941097992 0.1993026770900776 1.0 0.7618679863136887 10 P43490,O15173,Q8N0X7 3 +Positive regulation of homotypic cell cell adhesion 0.835943060498225 1.2818464925999296 0.1998965011496603 1.0 0.7626394508039719 2 Q9Y624 1 +Regulation of amyloid precursor protein catabolic process 0.5443978685424443 1.280424925905716 0.2003957322905893 1.0 0.763092023006554 11 O95197,Q9NQC3,P15260 3 +Vascular endothelial growth factor receptor signaling pathway 0.6123275236634222 1.2794397248595857 0.2007422524588098 1.0 0.7635676193466253 7 O14964,P04792 2 +Import into nucleus 0.3714333077413583 1.2786662936430873 0.201014594043374 1.0 0.7636867400796532 63 P55735,O00505,Q9BW27,Q99567,Q92973,O00629,P52294,Q06481,Q9UKG1,O75312,O60684,P57740,Q13501,Q9NW64 14 +T cell mediated immunity 0.5815999390430026 1.2781106251317311 0.2012104230851592 1.0 0.7638297693106202 9 Q9NUQ9,P04439 2 +Organic hydroxy compound biosynthetic process 0.3909603531667673 1.277533825369335 0.2014138463812602 1.0 0.7638297693106202 48 Q14739,Q16850,P37268,Q9UKR5,Q15392,O76054,O15270,P48449,Q9UKG1,Q14534,P00374,P04062,Q15800 13 +Negative regulation of binding 0.4165519060655169 1.2740943897693593 0.2026299664584594 1.0 0.7671911668670053 31 Q99829,Q9NVN8,Q8TEY7,Q92769,P62136,P09601,Q92797,P40855,Q96ST3,P30533,P10586 11 +Toll like receptor signaling pathway 0.5318857888413266 1.2726891393832134 0.2031283730446826 1.0 0.7671911668670053 12 Q9UKG1,Q9NPR9,Q9NQC3,Q06481 4 +Negative regulation of neuron death 0.4083874502025218 1.2726347854265148 0.2031476689289624 1.0 0.7671911668670053 36 Q01105,P50897,Q9UMX5,P45985,P09601,P04062 6 +Regulation of transcription from rna polymerase ii promoter in response to oxidative stress 0.8327402135231452 1.2687141172539331 0.2045430455412835 1.0 0.7710822603183306 2 P09601 1 +Protein k63 linked deubiquitination 0.5947583053391688 1.2664892352371733 0.2053379810058568 1.0 0.7728253625038491 8 P34897,P40818,Q8TEY7,Q9NXR7 4 +Myotube differentiation 0.5013436043216724 1.2629987901176527 0.2065896145236503 1.0 0.7748100435975274 15 Q9BYT8,Q8IV08,Q99523,Q9H7B4,P42345 5 +Fat cell proliferation 0.8313167259786479 1.2628799848856282 0.2066323139781949 1.0 0.7748100435975274 2 Q9C0B1 1 +N acetylglucosamine metabolic process 0.8306049822064211 1.2599635169324863 0.2076825235317501 1.0 0.7762960236114826 2 O60502 1 +Regulation of myotube differentiation 0.7948737280818235 1.2595105988726991 0.2078459643816379 1.0 0.7762960236114826 4 Q9BYT8,P42345 2 +Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway 0.8867924528301944 1.258940457750245 0.208051839158192 1.0 0.7762960236114826 3 P01889,P04439 2 +Phosphatidylserine metabolic process 0.8867741787965913 1.2588735183269444 0.2080760203062999 1.0 0.7762960236114826 3 Q8NCC3 1 +Positive regulation of calcium ion import 0.8302491103202969 1.258505435601212 0.2082090226516177 1.0 0.7762960236114826 2 O14936 1 +Multicellular organismal movement 0.6076673832063844 1.257506040855973 0.2085704529800294 1.0 0.7762960236114826 7 P78417,P10253 2 +Regulation of innate immune response 0.3966610618401546 1.256814549240848 0.2088207964063801 1.0 0.7762960236114826 44 Q16543,Q9NUD5,P01889,Q9NZ08,Q06481,O94992,Q9UKG1,P19474,Q96ST3,Q96PK6,Q06124,P04439 12 +Negative regulation of tumor necrosis factor superfamily cytokine production 0.8859645461028806 1.2559078999121729 0.2091493640231017 1.0 0.7762960236114826 3 P30536 1 +Keratan sulfate metabolic process 0.8857416060011434 1.2550913367118688 0.2094456050286333 1.0 0.7762960236114826 3 O43505 1 +Collagen metabolic process 0.5766470696655058 1.2530827106255238 0.2101756074421841 1.0 0.7763452316341699 9 Q32P28,P07858 2 +Positive regulation of ion transport 0.4008478964229054 1.252887771486899 0.2102465528048827 1.0 0.7763452316341699 41 P30536,P42858,P14174,P78417,P08183,O14936,Q9Y4C2 7 +Posttranslational protein targeting to endoplasmic reticulum membrane 0.591951210322912 1.2528071879327138 0.2102758851204935 1.0 0.7763452316341699 8 P46379 1 +Amyloid precursor protein biosynthetic process 0.7930911680911639 1.25267455250282 0.2103241707040806 1.0 0.7763452316341699 4 Q96IZ0,Q92542,Q9Y287 3 +Urogenital system development 0.4043324393697698 1.252201020408954 0.2104966242909431 1.0 0.7763452316341699 38 Q9BW27,P07602,O95470,P46379,Q9BW83,P04083,Q12769,O75844,P57740,P46109 10 +Regulation of monooxygenase activity 0.591328208021907 1.2497698757410014 0.211383623395716 1.0 0.7763452316341699 8 P00374,Q8WTV0,P06280 3 +Positive regulation of collagen metabolic process 0.8274021352313161 1.2468445660844445 0.2124544958864325 1.0 0.7763452316341699 2 P08670 1 +Regulation of nucleobase containing compound transport 0.5571740740207689 1.2464890706036915 0.2125848992064059 1.0 0.7763452316341699 10 Q9BYW2,Q08J23,Q07666,Q9ULX6 4 +Negative regulation of hormone secretion 0.6049901837196497 1.2448991585210163 0.2131688202601305 1.0 0.7763452316341699 7 Q16836,Q06124 2 +Negative regulation of peptide secretion 0.6049901837196497 1.2448991585210163 0.2131688202601305 1.0 0.7763452316341699 7 Q16836,Q06124 2 +Transmembrane receptor protein tyrosine kinase signaling pathway 0.3679560033610089 1.2436013493839957 0.2136463193152677 1.0 0.7763452316341699 64 Q9NQC3,Q9UKG1,Q9UQB8,P62993,Q16539,Q9Y5X3,Q9BZF1,O95470,P43490,Q06330,P46109,P11717,Q99523,Q9HCD5,Q9UNH7,Q06124,P31751,O14964,P04792,Q8IXJ6,Q07954,Q92572 22 +Response to hormone 0.3586880679507447 1.2423531543090038 0.2141062916313463 1.0 0.7763452316341699 155 P30536,Q99829,O75874,Q15392,P42785,Q9UKG1,P04083,Q9UQB8,P62993,Q14258,Q9UBS8,P09960,P07858,P16278,Q16539,Q9Y5X3,Q9BZF1,O43823,P21266,P43490,O15173,Q6RW13,O43865,Q969T9,P09601,Q99523,O15118,Q9HCD5,P04062,Q86X55,Q06124,Q16836,P31751,P40818,P35573,Q06481,P35613,Q9H7B4,Q92572,Q96PK6,P42345 41 +Carbohydrate derivative catabolic process 0.4077982471487197 1.2423144198278069 0.214120577091085 1.0 0.7763452316341699 34 P16278,Q9H773,Q9BTY2,Q13126,P54802,P08236,P06865,P04062,Q9NUJ1,O60502 10 +Negative regulation of tyrosine phosphorylation of stat protein 0.8256227758007091 1.23956007281408 0.2151381564092567 1.0 0.7772428935437267 2 Q8WXW3 1 +Organophosphate catabolic process 0.4109841622198503 1.2392485223847536 0.215253476119495 1.0 0.7772428935437267 32 Q8NHP8,Q8NCC3,Q9H773,Q8WTV0 4 +Regulation of muscle organ development 0.5887031937775951 1.2369694422618278 0.2160984274446389 1.0 0.7785460376372813 8 Q8IXJ6,Q13131,P16989 3 +Stress activated protein kinase signaling cascade 0.4134428087493044 1.2363039811483023 0.2163455918398551 1.0 0.7785460376372813 30 O15344,Q16539,P29372,P78318,Q99873,P45985,Q96KB5,Q02750,P49327,O75844,P46109,Q53EL6,Q7L7X3 13 +Regulation of phospholipase a2 activity 0.7888176638176563 1.236288031225654 0.2163515184281603 1.0 0.7785460376372813 4 Q07954,P50897,P04083 3 +Neuron recognition 0.7877960645534192 1.2323713165323296 0.2178104105457228 1.0 0.7829067337653123 4 Q9NQC3 1 +Porphyrin containing compound metabolic process 0.4786980059280754 1.2306918854635214 0.2184381241582644 1.0 0.7844531103229477 18 P30536,P30519 2 +Negative regulation of dna templated transcription elongation 0.5870913083468179 1.2291072919577706 0.2190315815334118 1.0 0.7846258519939123 8 Q8WX92,Q4G0J3,O94992,Q8IXH7,O14776 5 +Response to zinc ion 0.6898143691773684 1.2273181064412957 0.2197030528331305 1.0 0.7861424312837652 5 P30536 1 +Nuclear transcribed mrna catabolic process exonucleolytic 0.4997063075031093 1.2250215866342915 0.2205670872828009 1.0 0.7880473138446876 14 Q96C86,Q6PGP7,Q969T7,Q96B26 4 +Regulation of alcohol biosynthetic process 0.6315049575982166 1.223725369022078 0.2210558461477636 1.0 0.7880473138446876 6 P16435,O76054,O75477 3 +Regulation of cholesterol biosynthetic process 0.6315049575982166 1.223725369022078 0.2210558461477636 1.0 0.7880473138446876 6 P16435,O76054,O75477 3 +Polyol biosynthetic process 0.5340384456172322 1.2234325233443186 0.2211663755648558 1.0 0.7880473138446876 11 O15270,P04062 2 +Negative regulation of ion transmembrane transport 0.5113249895753303 1.2214842030839863 0.2219027431099745 1.0 0.7885824864863062 13 P78417,Q06787,P62942,P21796 4 +Regulation of lipase activity 0.533273599417811 1.219221237229947 0.22276023346198 1.0 0.7885824864863062 11 P50897,Q99523,P16435,P04083,Q07954 5 +Protein targeting to vacuole 0.5109236934861213 1.2191385345176908 0.2227916163020282 1.0 0.7885824864863062 13 O14964,Q14108,Q9Y2T2 3 +Positive regulation of glial cell differentiation 0.6876604825612043 1.2183879783846985 0.2230765712708111 1.0 0.7885824864863062 5 Q92769,P42345 2 +Modification of postsynaptic actin cytoskeleton 0.7834757834757627 1.2158106790724286 0.2240570497965388 1.0 0.7885824864863062 4 P35080,P07737,Q9UQB8 3 +Pyridine containing compound metabolic process 0.598214444333323 1.2129753645800383 0.2251392394697027 1.0 0.7885824864863062 7 Q13126 1 +Negative regulation of inflammatory response 0.5683756436934391 1.2112452452245166 0.2258014269289989 1.0 0.7885824864863062 9 Q9H000,Q96KB5,P04062,P28070 4 +Isocitrate metabolic process 0.6857560413749003 1.2104920189527544 0.2260901514193003 1.0 0.7885824864863062 5 P48735 1 +Regulation of keratinocyte migration 0.7816951566951634 1.2089866918422474 0.2266679582095441 1.0 0.7885824864863062 4 P58107,Q15555,P42345 3 +Keratinocyte migration 0.7816951566951634 1.2089866918422474 0.2266679582095441 1.0 0.7885824864863062 4 P58107,Q15555,P42345 3 +Cerebellar cortex formation 0.628076609991009 1.2084423354958276 0.2268771637772775 1.0 0.7885824864863062 6 Q06124,P04062 2 +Regulation of peptidyl lysine acetylation 0.4680700689746138 1.206369850566663 0.2276749156460547 1.0 0.7885824864863062 19 Q01105,Q96ST2,Q92769,Q969T9,Q96ST3,Q03164,O75844 7 +Negative regulation of single stranded viral rna replication via double stranded dna intermediate 0.5967709776723452 1.2061718472778116 0.2277512366062728 1.0 0.7885824864863062 7 P52926,Q9UK61,Q9NRW3,Q15047 4 +Unsaturated fatty acid metabolic process 0.4679964759858565 1.2058669878311938 0.2278687812338904 1.0 0.7885824864863062 19 P07099,P14174,Q14914,P04083,Q8N4Q0,Q9H7Z7 6 +Regulation of cartilage development 0.7807243926085281 1.2052668172493115 0.2281003152484455 1.0 0.7885824864863062 4 Q06124,Q92896 2 +Regulation of chondrocyte differentiation 0.7807243926085281 1.2052668172493115 0.2281003152484455 1.0 0.7885824864863062 4 Q06124,Q92896 2 +Regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay 0.5195342790409664 1.2027033499397213 0.2290911371165989 1.0 0.7897658298886946 12 Q14103,P67809,O60506,Q9H074 4 +Developmental maturation 0.3978765838044915 1.2021124885950274 0.229319948412896 1.0 0.7897658298886946 39 Q8N2A8,O75179,Q8IXJ6,Q9UJX6,P18074,P30153,Q08J23,O75503,P07737,P04062 10 +Intrinsic apoptotic signaling pathway 0.3612353722979614 1.2011835747302602 0.2296799994112841 1.0 0.7901640370625992 69 O95881,Q07820,P16989,Q9NR28,P46379,P09601,P45880,P61978,Q96K76,O60443 10 +Metal ion homeostasis 0.3576025144444734 1.2005234869321535 0.2299360965723103 1.0 0.7906158675956214 73 Q8NE01,Q9HD20,P42858,Q9Y487,P78417,P09601,Q15904,P62942,Q8N511,P30519,Q7L0J3 11 +Amide transport 0.4061017878967279 1.1969603605499397 0.2313220054244724 1.0 0.7910829843456817 32 P07602,P04083,P08183,P53985,Q9H2D1,Q06124 6 +Chromosome organization involved in meiotic cell cycle 0.4855302217480965 1.1965096173045486 0.2314977478111766 1.0 0.7910829843456817 16 Q92791,O60216,Q9BTX1,P46379 4 +Regulation of neurogenesis 0.3680876296940977 1.193046168876839 0.2328512920337027 1.0 0.7917636030125248 54 P30536,Q9NQC3,Q92769,Q9UJX6,Q8N0X7,Q02750,Q06481,Q9UBS4,P55209,Q9UQB8,Q8IXJ6,Q96G23 12 +Immune effector process 0.3624562206544757 1.1915062313215647 0.2334549118559579 1.0 0.7917636030125248 66 Q5RKV6,P68371,P14174,Q9UKG1,P04083,O96028,P04439,Q01650,Q96FV9,P01889,Q96FZ2,O75179,P09601,Q9NUQ9,P17931,Q06481,Q9UQ84,P07437,Q07954,P42345 20 +Cellular macromolecule localization 0.2810681807181852 1.1910967639525258 0.2336156001194427 1.0 0.7917636030125248 481 P30536,Q9NS69,Q9Y282,Q8TB36,Q99595,O60830,Q99567,Q9UK61,Q9Y3I1,Q10713,O14925,P40855,Q9Y6X3,Q9NW64,O00505,Q16539,Q14789,O00629,P52294,O95831,P46379,P10619,O60725,O15118,Q14108,Q96DY7,Q06124,P30419,Q9HD20,O14773,Q06481,Q15437,O14936,P43307,P55735,Q9UFC0,Q5JRX3,Q9Y512,O15260,O14737,Q8NFQ8,O60684,Q9Y4C2,O43765,Q15555,Q92783,Q9P2W9,Q9BW83,P67809,Q9Y679,P31751,O14976,O14964,Q8N4H5,Q9Y6C9,Q15904,Q9Y624,Q92572,Q9Y2T2,Q9NQC3,Q9HD45,Q8TD16,P57740,O00264,Q16543,Q92973,Q9BZF1,Q15629,Q8TCT9,Q8WXW3,O43865,Q4VCS5,Q9UHB9,Q99523,Q14168,Q96S97,Q99729,Q9BYW2,Q9H223,Q07954,Q9NVN8,P55786,O60216,Q9UKG1,O75312,O00471,P50402,P11233,Q9Y5X3,P31483,P46109,O15344,Q9BW27,Q4G0J3,Q12955,O15027,Q96ST3,Q13501,P17931,P04792,P35613 101 +Cellular polysaccharide catabolic process 0.5932180051018441 1.1894224339556978 0.2342734771971792 1.0 0.7917636030125248 7 P10253,P35573 2 +Polysaccharide catabolic process 0.5932180051018441 1.1894224339556978 0.2342734771971792 1.0 0.7917636030125248 7 P10253,P35573 2 +Regulation of histone phosphorylation 0.7765372691333321 1.1892260722727284 0.2343507174583226 1.0 0.7917636030125248 4 Q9ULX6,O43823 2 +Positive regulation of proteasomal ubiquitin dependent protein catabolic process 0.4390723028949367 1.1846677050776857 0.2361488560807383 1.0 0.7934731431495695 22 O43765,O75832,Q9H000,Q9Y5A7,Q96HY6,P04062,Q8IXJ6,Q9UBS8 8 +Tyrosine phosphorylation of stat protein 0.6793729960812206 1.184028816409251 0.2364016560306749 1.0 0.7934731431495695 5 Q9UIV1,Q8WXW3,Q92769,P30153 4 +Regulation of cyclin dependent protein kinase activity 0.4882370900570505 1.1820843137256092 0.2371722478575508 1.0 0.7952172141128571 15 Q16543,O00410,O75832,Q9Y3B8,Q9Y3I1,Q9P287,O94992,Q96JB5 8 +Regulation of lipophagy 0.8655347433983869 1.1811862655508651 0.2375287361486893 1.0 0.7959913278552322 3 O15270 1 +Cerebellar cortex development 0.4921965042363389 1.1796686305171462 0.2381320350162543 1.0 0.7975912821871055 14 Q5KU26,Q02750,O94992,P54802,P04062,Q06124 6 +Regulation of glycoprotein metabolic process 0.5618978073235601 1.1784533486864206 0.2386159201497624 1.0 0.798004479915056 9 Q9Y287,Q9NY61,Q92542,Q96IZ0,O14734 5 +Response to insulin 0.3667430043834223 1.178290697921475 0.2386807349315309 1.0 0.798004479915056 54 Q16539,Q7L576,Q16836,P31751,Q9Y5X3,Q9BZF1,Q06481,Q99523,Q9UKG1,P43490,Q96A49,Q9HCD5,Q9UQB8,Q13243,P62993,Q92572,P42345,Q06124 18 +Nucleotide transmembrane transport 0.621003127690882 1.1769028655970015 0.239234278198166 1.0 0.798004479915056 6 Q9H2D1 1 +Pteridine containing compound metabolic process 0.4870643213504612 1.1748397791056138 0.2400588221675361 1.0 0.7992617984827525 15 P00374,Q9H2D1,Q92820 3 +Ceramide transport 0.6768566114441346 1.173597600642021 0.2405562427191254 1.0 0.8002125512394216 5 P07602 1 +Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.4068324333150768 1.1714961400517567 0.2413994084505626 1.0 0.8014587920137434 29 Q5RKV6,P52701,Q96FV9,P01889,Q96FZ2,P13051,Q12888,P04083,P53634,O96028,Q9UQ84,Q9NUQ9,P42345,P04439 14 +Regulation of response to dna damage stimulus 0.3599418963993821 1.168852743923521 0.2424629656572654 1.0 0.8044438813455974 67 Q9BYW2,Q96FW1,O75832,Q07820,Q06787,P51116,P14174,Q9NXR7,P35637,P61978,O96028,O75844,P51114,Q96K76 14 +Positive regulation of protein dephosphorylation 0.5021844112214767 1.1680354810782203 0.2427924532171461 1.0 0.8046212434207124 13 Q92797,Q86XL3,P04062 3 +Positive regulation of g1 s transition of mitotic cell cycle 0.5131152060623603 1.166294820514551 0.2434952666032379 1.0 0.8046212434207124 12 P04083,Q96DY7,O75179 3 +Exonucleolytic catabolism of deadenylated mrna 0.5417584936542907 1.1651998576090332 0.243938103268873 1.0 0.8046212434207124 10 Q9Y2L1,Q96C86,Q969T7,Q96B26 4 +Regulation of lymphocyte activation 0.3755441942121258 1.1646788583722274 0.2441490098673833 1.0 0.8046212434207124 50 Q8WXW3,Q5RKV6,P14174,Q9Y3I1,Q96FV9,Q96FZ2,Q92990,Q96IZ0,P04083,O96028,P10644,Q06124,Q9NUQ9,P17931,P04439 15 +Fatty acid transmembrane transport 0.6181759501427169 1.16429570596078 0.2443041961448582 1.0 0.8046212434207124 6 O43772,P31751 2 +Regulation of metal ion transport 0.3753406935337771 1.1625537557865473 0.2450106025342355 1.0 0.8046212434207124 50 P30536,P42858,O43865,P78417,P21796,P62942,O14936 7 +Negative regulation of calcium ion transport into cytosol 0.7693369388196454 1.161659427721363 0.2453738322518077 1.0 0.8046212434207124 4 P78417 1 +Negative regulation of ryanodine sensitive calcium release channel activity 0.7693369388196454 1.161659427721363 0.2453738322518077 1.0 0.8046212434207124 4 P78417 1 +Positive regulation of sequestering of calcium ion 0.7693369388196454 1.161659427721363 0.2453738322518077 1.0 0.8046212434207124 4 P78417 1 +Mitotic g2 dna damage checkpoint signaling 0.5732011734543982 1.1613081557698837 0.2455166039822069 1.0 0.8046212434207124 8 Q9NXR7 1 +Response to dietary excess 0.8064056939501929 1.1610951365532265 0.2456032123465783 1.0 0.8046212434207124 2 Q06481 1 +Positive regulation of myotube differentiation 0.8064056939501795 1.1610951365531712 0.2456032123466007 1.0 0.8046212434207124 2 P42345 1 +Cartilage development 0.5121357124889949 1.1607379498225612 0.2457484837497936 1.0 0.8046212434207124 12 P04818,Q16539,P16435,Q96HY6,O75844,Q06124,Q92896 7 +Lymphocyte activation 0.328654540784919 1.1601979193127854 0.2459682339341573 1.0 0.8046212434207124 90 Q5RKV6,P14174,Q9Y3I1,P04083,O96028,P10644,P04439,Q96FZ2,Q96FV9,Q92990,Q12888,P46379,P62942,Q8WXW3,Q92542,P04062,Q9NUQ9,P17931,Q06124,P78318,Q96IZ0,P17812,Q9UQ84,P42345,P13051 25 +Response to steroid hormone 0.3610100420480692 1.1576405368165743 0.2470107594241923 1.0 0.806859372407787 63 P30536,P16278,O75874,Q969T9,P35573,P04083,O15118,O15173,Q9H7B4,P04062,Q86X55 11 +Fibroblast growth factor receptor signaling pathway 0.6727710363363818 1.1566643788962907 0.2474095084186449 1.0 0.8068627575609895 5 Q06124 1 +Regulation of b cell activation 0.4835707342919132 1.1532572396503795 0.2488048155847284 1.0 0.8068627575609895 15 Q5RKV6,Q96FZ2,Q96FV9,Q96IZ0,P14174,O96028 6 +Odontogenesis of dentin containing tooth 0.6156473307364381 1.153019946291356 0.2489021975973555 1.0 0.8068627575609895 6 Q92769,Q6P4Q7 2 +Carbohydrate transport 0.4784799116540528 1.151922307613932 0.2493530005397204 1.0 0.8068627575609895 16 P31751,Q9BZF1,Q06481,Q99523,Q06124 5 +Prenylation 0.8573083721001415 1.151175680292612 0.249659968160522 1.0 0.8068627575609895 3 P49356 1 +Vitamin d metabolic process 0.8039145907473468 1.1509562368819684 0.2497502400956774 1.0 0.8068627575609895 2 P04062 1 +Regulation of long term synaptic potentiation 0.6712663306145983 1.15042902262546 0.2499672122256058 1.0 0.8068627575609895 5 Q92542,Q9BPZ3 2 +Regulation of cilium assembly 0.4871080431771978 1.148928916310928 0.2505852929506891 1.0 0.8068627575609895 14 Q15555,P42858 2 +Positive regulation of lipid metabolic process 0.4827921847933301 1.1484473866845908 0.2507839210392308 1.0 0.8068627575609895 15 Q8WTV0,P31751,Q13131,P16435,P04083,P42345 6 +Positive regulation of fatty acid metabolic process 0.8564552459429529 1.1480665181842642 0.2509411048369792 1.0 0.8068627575609895 3 P31751 1 +Axon ensheathment in central nervous system 0.8032028469750889 1.148060973700823 0.2509433935437379 1.0 0.8068627575609895 2 Q92542 1 +Regulation of epithelial cell migration 0.3915028325595018 1.142771648574528 0.2531334129617941 1.0 0.8094420694838279 39 Q16539,Q9NQC3,Q8WTV0,Q15555,P58107,P35080,P42785,P09601,P04083,P04792,P07737,Q13685,P42345 13 +Nitrogen compound transport 0.2807400912307733 1.1407008927978912 0.253994414916588 1.0 0.8094420694838279 521 P30536,A6NIH7,Q9NS69,Q9Y282,Q99595,O60830,P53985,O00505,O00629,P52294,P46379,O15173,Q9H2D1,P10619,P50897,Q16850,O60725,O43772,Q14108,Q06124,Q32P28,P30419,Q9HD20,P07602,Q9ULX6,Q06481,Q15437,P43307,P55735,Q5JRX3,Q9Y512,O43823,Q92945,O15260,O14737,O60684,Q9Y4C2,O43765,Q92783,Q9P2W9,Q9Y619,P08183,Q9BW83,P67809,Q9Y679,Q07820,P31751,O14964,Q8N4H5,Q8NFH4,Q96PC5,Q15904,Q92572,Q9Y2T2,Q7L0J3,Q8TD16,P04083,Q08J23,P57740,P22626,Q16543,Q92973,Q8IUD2,O95721,Q15629,Q07666,Q8TCT9,O43865,Q9UHB9,Q99523,Q14168,Q9BYW2,Q06787,Q16836,Q07954,Q8TB61,Q13432,P55786,Q9UKG1,O75312,O00471,Q8N6H7,Q01650,P50402,Q96FV9,Q9Y5X3,Q12907,Q8NI77,Q9BW27,Q96ST2,Q96PU8,Q969M3,Q12955,O15027,Q8N183,Q13501 96 +Negative regulation of protein polymerization 0.4147547004224065 1.1396227034509945 0.2544435225519623 1.0 0.8094420694838279 24 Q9NUQ9,P45880,P35080,Q96S97 4 +Cellular response to xenobiotic stimulus 0.423708038995884 1.1374290751082838 0.255358958443316 1.0 0.8111326915565381 23 P78417,P07099,O43169 3 +Lymphocyte migration 0.5678027167835797 1.1349442703146344 0.2563986693988713 1.0 0.8134494802444603 8 Q9Y624,P04062 2 +Long chain fatty acid transport 0.5179462238242086 1.1347658941687648 0.2564734198403711 1.0 0.8134494802444603 11 P14174,P04083,O43772,P31751 4 +Regulation of nitric oxide synthase activity 0.6672514163185977 1.1337952472895478 0.2568804450758106 1.0 0.8139256902227061 5 Q8WTV0,P06280 2 +Positive regulation of cell cell adhesion 0.4041847732540069 1.1310749055227909 0.2580235654062592 1.0 0.8155088947528504 25 Q9NUQ9,Q9Y624,Q06124,P04439 4 +Response to arsenic containing substance 0.5349637068386555 1.1293407358474186 0.2587541228232644 1.0 0.8174102075428845 10 P78417,P09601 2 +Outflow tract morphogenesis 0.6660261488164136 1.1287201794008932 0.2590158938910134 1.0 0.8178294566952428 5 P46109 1 +Negative regulation of cell cycle g2 m phase transition 0.4747580308457301 1.1283821186372662 0.2591585761872612 1.0 0.8178724588140809 16 O60216,Q9NXR7,Q9Y619,Q96K76,Q7L7X3 5 +Adiponectin activated signaling pathway 0.760372975504485 1.127380171863087 0.2595817787264436 1.0 0.8183929013877975 4 Q06481 1 +Lipoprotein catabolic process 0.7600994249810226 1.1263348942302214 0.2600237931509799 1.0 0.8189715592434194 4 P50897 1 +Protein depalmitoylation 0.7600994249810226 1.1263348942302214 0.2600237931509799 1.0 0.8189715592434194 4 P50897 1 +Negative regulation of lymphocyte mediated immunity 0.8494126023496003 1.1224249374550936 0.2616818063824699 1.0 0.8205575612831623 3 P01889,P04439 2 +Negative regulation of cell projection organization 0.4030910233683301 1.1222694029655478 0.2617479113943797 1.0 0.8205575612831623 25 Q9NQC3,O14976,P08670,Q8N0X7,P35080,Q86X55,Q96G23 7 +Negative regulation of neuron projection development 0.4735663573534203 1.120845382605257 0.262353682721165 1.0 0.8213131508194625 16 Q9NQC3,O14976,P08670,Q8N0X7,Q86X55,Q96G23 6 +Embryonic organ development 0.3880178625552341 1.1201491577888565 0.2626502055490052 1.0 0.8213131508194625 40 Q9BVA1,Q9BYW2,Q9H6E4,Q02750,P62995,P54802,P42892,Q03164 8 +Ion transport 0.357468741583608 1.1200056856225995 0.2627113392316633 1.0 0.8213131508194625 187 P30536,P14174,Q70HW3,P21796,Q9C0H2,P45880,P04083,Q96ES6,P36543,O75964,P53985,O15173,P62942,Q9UHG3,O75844,Q6P4Q7,Q9UBX3,Q9H2D1,Q9Y4C2,O43865,P78417,O43772,Q9Y619,P08183,Q8NE01,Q9HD20,P07602,P42858,P47985,O14936,Q7L0J3 31 +Neuron development 0.3507158902454594 1.1195866922647606 0.2628899291045745 1.0 0.8214662133805172 155 P30536,Q99829,Q9NQC3,P08670,Q8NHS3,O75503,Q9UQB8,O75312,Q96G23,O00264,Q8TEY7,P46109,P50897,Q15555,Q99873,Q8N0X7,Q12955,P54802,Q14108,P42892,P04062,Q86X55,Q96ST3,Q9BW83,Q7L7X3,Q32P28,Q06124,Q06787,Q92769,O14976,Q9UJX6,Q02750,Q06481,P00374,Q9BVA1 35 +Synaptic membrane adhesion 0.7957295373665498 1.1177053587068535 0.2636928533442841 1.0 0.8218561632703463 2 Q16539 1 +Lung cell differentiation 0.7575034820050914 1.1164180705620137 0.2642432219789816 1.0 0.8218561632703463 4 P09960 1 +Positive regulation of filopodium assembly 0.7574908978285374 1.1163700094874724 0.2642637853915848 1.0 0.8218561632703463 4 Q06787 1 +Base excision repair ap site formation 0.7950177935943068 1.1148188144100817 0.2649280723061464 1.0 0.8221592527933644 2 P13051 1 +Rna destabilization 0.3847012574729432 1.1118387276462045 0.2662074971999746 1.0 0.8239758187269771 42 Q14103,P67809,O60506,Q9H074,P11940,Q969T7,Q96B26,Q92945,O15514,Q96C86,Q9Y2L1,Q14671,Q86VM9,Q9C0B1 14 +Negative regulation of regulated secretory pathway 0.7556301576827887 1.1092648594934351 0.2673159397853157 1.0 0.8257320801410948 4 P09601 1 +Negative regulation of actin filament bundle assembly 0.5625129655076725 1.1091107832073073 0.267382393632559 1.0 0.8257320801410948 8 Q9Y624,P63167,Q07157,P07737 4 +Fatty acid transport 0.480270781704134 1.1076265568837813 0.2680231293247246 1.0 0.825814181962794 14 P31751,P14174,P29375,O43772,P04083 5 +Regulation of mrna metabolic process 0.3480638256827372 1.1074555255691318 0.2680970307219665 1.0 0.825814181962794 149 Q9H074,Q96B26,P16989,P51116,P08670,P38159,Q13310,P35637,P22626,Q9C0B1,P11940,Q969T7,Q92945,Q13242,Q14671,P31483,P51114,Q9UHX1,Q07666,P51003,Q92804,O60506,Q96ST2,Q96PU8,O43865,Q4G0J3,P61978,Q99729,Q9BWF3,Q14011,O75525,Q14103,P67809,Q06787,P98175,P62995,P98179,Q96C86 38 +Positive regulation of rig i signaling pathway 0.8451406194375313 1.1068943448212654 0.2683396112001448 1.0 0.825814181962794 3 Q9NUD5,O75179 2 +Glycosylceramide metabolic process 0.8449864880056583 1.1063343584624556 0.2685818256312637 1.0 0.825814181962794 3 P04062 1 +Negative regulation of amyloid precursor protein biosynthetic process 0.7925266903914735 1.104722386493856 0.2692799000498354 1.0 0.8259614682844747 2 Q9Y287 1 +Hormone mediated signaling pathway 0.3888112603873521 1.1015119678616514 0.2706738986816441 1.0 0.8262667482794682 37 Q06481,O15173,Q06124,P42785 4 +Negative regulation of muscle cell differentiation 0.5462581959574818 1.0992400004924865 0.2716633954083385 1.0 0.8262667482794682 9 P67809,O75179 2 +Regulation of b cell mediated immunity 0.5111207629071383 1.0971419787271202 0.2725793319856677 1.0 0.8262667482794682 11 Q5RKV6,Q96FZ2,Q96FV9,Q12888,O96028 5 +Regulation of isotype switching 0.5111207629071383 1.0971419787271202 0.2725793319856677 1.0 0.8262667482794682 11 Q5RKV6,Q96FZ2,Q96FV9,Q12888,O96028 5 +Regulation of dna binding 0.4183935431019536 1.097074420980855 0.2726088608482802 1.0 0.8262667482794682 23 Q99829,Q92769,Q8IXJ6,P09601,O60869,Q96ST3,O75844 7 +Establishment of protein localization 0.277073588396076 1.0962374632334464 0.2729748688199975 1.0 0.8268841987152603 467 P30536,P55735,A6NIH7,Q9NS69,Q9Y282,Q99595,O60830,Q8TD16,P04083,O96028,Q9UFC0,P53985,Q5JRX3,P57740,Q16543,O00505,Q9Y512,Q92973,O00629,P52294,P46379,O43823,Q8IUD2,O15260,O14737,Q53EZ4,O95721,Q15629,O60684,Q9Y4C2,O43765,Q8TCT9,P10619,P50897,Q16850,Q92783,O60725,O43865,Q969T9,Q9P2W9,Q9UHB9,Q99523,O15118,Q14108,Q9BW83,Q06124,Q32P28,P30419,Q9HD20,Q9Y679,Q07820,P31751,O14964,Q8N4H5,Q8NFH4,Q06481,Q96PC5,Q15437,Q15904,Q9Y2T2,Q92572,P43307 62 +Process utilizing autophagic mechanism 0.3429877480425672 1.095660612619502 0.2732273255417325 1.0 0.827253493529842 137 P30536,P21796,Q8NHS3,P36543,Q16543,Q8TEY7,Q9Y487,Q93050,O75844,P10619,Q92783,O15270,P09601,O15118,P04062,Q9Y679,P07602,Q07820,P42858,O14964,P19474 21 +Response to fibroblast growth factor 0.6026729360278891 1.0951797400065153 0.273437899800701 1.0 0.8274956881743277 6 Q06124 1 +Regulation of cell cycle phase transition 0.3251753008876386 1.09052933153899 0.2754800399740347 1.0 0.8298389086487192 101 Q9Y3I1,O60216,Q9UKG1,P04083,Q08J23,Q8N6R0,Q9UJX2,Q16539,Q13564,Q96FV9,P18074,Q12888,Q13042,P31350,O43670,O75179,Q9NXR7,Q9Y619,Q96ST3,Q96K76,Q9UJX3,Q96DY7,Q7L7X3,Q06124,Q9UJX4,Q06481,Q9UL46,Q8IXJ6,Q96RU2 29 +Positive regulation of mapk cascade 0.3875896920455668 1.0903345694367492 0.2755657925866668 1.0 0.8298389086487192 37 O15344,Q9UMX5,P14174,Q02750,Q15750,O60443,P46109,Q06124,Q7L7X3 9 +Negative regulation of response to stimulus 0.3571464195732649 1.0898868475462358 0.2757629909672519 1.0 0.8298389086487192 208 Q99829,P30086,Q96FW1,P16989,P14174,Q10713,Q9UKG1,P45880,P04083,Q96G23,P04439,Q16539,P50402,Q9UMX5,Q96FV9,P01889,Q9Y5X3,Q14247,Q12888,P62942,Q9NPR9,P30533,P80303,Q53EL6,O76024,O43765,O95881,Q8WXW3,P61289,Q9NY61,Q8N0X7,P58107,P09601,Q9HCD5,Q96S97,P04062,Q96K76,Q9NUQ9,Q96KB5,Q8N183,P17931,Q92896,P78318,P67809,O75832,Q07820,P42858,Q9H000,O14964,Q96IZ0,Q9UJX6,P30153,Q06481,P28070,P04792,P19474,Q8IXJ6,Q07954,O14936,O43657,P42345 61 +Stress granule assembly 0.4632603620038993 1.0889200970664965 0.2761891229507145 1.0 0.8298389086487192 17 Q13131,Q7Z739,Q9Y520,P31483,Q14011 5 +Rhythmic process 0.3558520506146886 1.0883660405911866 0.2764335467024932 1.0 0.8298389086487192 55 P04818,P62136,P29375,P04083,Q03164,Q05086,O95470,Q13131,P43490,Q00839,P54802,Q96ST3,Q9BWF3,Q93009,O14744,Q14103,O00429,Q92769,P17844,Q16531,P42345 21 +Artery development 0.5582016057561793 1.088058417859879 0.2765693190888583 1.0 0.8298389086487192 8 Q96AY3,Q15750,Q07954 3 +Histone h4 acetylation 0.4424413198775693 1.085757696267974 0.2775862070393033 1.0 0.8304749163757346 20 Q03164,Q86UY6 2 +Immunoglobulin production involved in immunoglobulin mediated immune response 0.4676270066786238 1.0832897226484477 0.2786798456051658 1.0 0.8304749163757346 16 Q5RKV6,P52701,Q96FZ2,Q96FV9,Q12888,O96028,Q9UQ84,P13051 8 +Somatic diversification of immunoglobulins involved in immune response 0.4676270066786238 1.0832897226484477 0.2786798456051658 1.0 0.8304749163757346 16 Q5RKV6,P52701,Q96FZ2,Q96FV9,Q12888,O96028,Q9UQ84,P13051 8 +B cell activation involved in immune response 0.4676270066786238 1.0832897226484477 0.2786798456051658 1.0 0.8304749163757346 16 Q5RKV6,P52701,Q96FZ2,Q96FV9,Q12888,O96028,Q9UQ84,P13051 8 +Cellular response to insulin stimulus 0.3772939858169296 1.08302951662499 0.2787953218668373 1.0 0.8304749163757346 45 Q7L576,P31751,Q9Y5X3,Q9BZF1,Q06481,Q96A49,Q9UKG1,P43490,Q9HCD5,Q9UQB8,Q13243,P62993,Q92572,Q06124 14 +3 utr mediated mrna stabilization 0.5429764778798707 1.082619428409137 0.2789773800869397 1.0 0.8304749163757346 9 Q16539,P98175,P16989 3 +Vacuolar transport 0.3772247050119233 1.0823452811371757 0.2790991325600283 1.0 0.8304749163757346 45 P07602,Q92783,P11717,O14976,O14964,Q99523,O15118,Q14108,Q92572,Q9Y2T2 10 +Signal peptide processing 0.6547913141208122 1.0822203975495526 0.2791546070114297 1.0 0.8304749163757346 5 O75503 1 +Regulation of transposition 0.78683274021352 1.0816844750349024 0.2793927539091536 1.0 0.8304749163757346 2 Q9NRW3 1 +Transposition 0.78683274021352 1.0816844750349024 0.2793927539091536 1.0 0.8304749163757346 2 Q9NRW3 1 +Regulation of phospholipid metabolic process 0.5568916635858678 1.08166294707011 0.2794023231360369 1.0 0.8304749163757346 8 Q8WTV0,O75874 2 +Somatic diversification of immune receptors via somatic mutation 0.5990511283252009 1.0790434001560856 0.2805683808388328 1.0 0.8320553303046906 6 Q9UQ84,P13051 2 +Peptidyl proline modification 0.3973847044669684 1.078043304011851 0.2810144313465417 1.0 0.8320553303046906 26 Q32P28,O75718,Q96AY3,P62942,Q9BV86,P13674 6 +Maternal process involved in female pregnancy 0.5415760947517375 1.0755279681895722 0.2821384174171757 1.0 0.8320553303046906 9 Q9BQE5,P07858 2 +Magnesium ion homeostasis 0.8362406550373843 1.0746023597887562 0.2825527948994877 1.0 0.8320553303046906 3 Q8NE01,Q6P4Q7 2 +Golgi to vacuole transport 0.5686800362098482 1.0737142664924184 0.2829507652126597 1.0 0.8320553303046906 7 O14976,Q92572 2 +Mrna catabolic process 0.3251823150130239 1.073635880281162 0.2829859096939309 1.0 0.8320553303046906 103 Q9H074,Q5RKV6,Q96B26,P16989,P51116,P08670,Q13310,P35637,Q9C0B1,Q9BRP8,P11940,Q969T7,Q92945,P51114,Q92804,O60506,Q6PGP7,Q99729,Q14011,Q14103,P67809,Q06787,P98175,Q96C86 24 +Positive regulation of cytokine production 0.3544371376887397 1.0726235412088043 0.2834400580005476 1.0 0.8324315265008498 55 Q9NUQ9,Q01650,Q8WXW3,P15260,Q92769,P14174,Q9NUD5,Q92990,P09601,Q9UKG1,P04083,Q99943,Q9BYW2,O60684,Q06124,P04439 16 +Circadian rhythm 0.3790027395869679 1.0700995339991906 0.2845745088667843 1.0 0.8329891285474917 43 P04818,O14744,Q14103,Q16531,Q92769,Q00839,P62136,P29375,Q13131,P43490,P54802,Q96ST3,Q03164,Q05086,Q9BWF3,Q93009,P42345 17 +Regulation of cellular response to stress 0.342436652789893 1.0698796167740618 0.284673499083883 1.0 0.8329891285474917 140 Q96FW1,P16989,P51116,P14174,Q9Y3I1,P35637,O43813,O96028,Q96G23,Q96FV9,Q12888,P46379,O75844,P51114,Q53EL6,P10586,O76024,P29372,O95881,O43765,O15344,Q99873,P49327,Q9NXR7,P61978,Q96K76,Q99543,Q9BYW2,Q96KB5,Q7L7X3,P78318,P67809,Q06787,O75832,Q07820,Q9H993,Q96IZ0,Q02750,P04792,P00374,P42345 41 +Regulation of apoptotic signaling pathway 0.3346206406877343 1.0692970630592753 0.2849358335915841 1.0 0.8329891285474917 83 P16989,P62136,P14174,P45880,Q14247,P30154,O76024,O95881,P61289,Q9NY61,P49327,P09601,P61978,O60443,Q96K76,P17931,O00429,Q07820,P42858,O75832,P30153,P04792 22 +Negative regulation of mrna splicing via spliceosome 0.4653302401423448 1.0687723373881877 0.2851722670121792 1.0 0.8329891285474917 16 P61978,P98175,P22626,P38159 4 +Glycine biosynthetic process 0.7836298932384471 1.0687513273104068 0.285181736595792 1.0 0.8329891285474917 2 P00374 1 +Serine family amino acid catabolic process 0.7836298932384345 1.0687513273103546 0.2851817365958156 1.0 0.8329891285474917 2 P23378 1 +Biological process involved in interaction with host 0.3641280609879941 1.0687479618255658 0.2851832534942806 1.0 0.8329891285474917 51 O00505,Q8WTV0,O15118,Q14108,P19474,P07858 6 +Lipid homeostasis 0.4317290280150993 1.0680443850514223 0.2855004909169185 1.0 0.8329891285474917 21 Q9NQC3,Q8WTV0,Q9Y6C9,Q5BJF2,O15260,O15118 6 +Leukocyte mediated immunity 0.3787594199669839 1.0677456075153935 0.2856352795750085 1.0 0.8329891285474917 43 Q96FZ2,P01889,P09601,O96028,Q9UQ84,P07437,Q9NUQ9,P04439 8 +Face development 0.5538010631101907 1.066576338078396 0.2861631900974519 1.0 0.8333713858674416 8 Q02750,Q12797,O95470,Q06124 4 +Head morphogenesis 0.6506442782312437 1.065076336756725 0.2868413865761448 1.0 0.83403060740343 5 O95470,Q12797,Q06124 3 +Skeletal muscle contraction 0.8335647202089624 1.0649114455747717 0.2869160050717181 1.0 0.83403060740343 3 P78417 1 +Post translational protein modification 0.5223501973840139 1.0627789229938145 0.287882219951709 1.0 0.8353580043560827 10 Q32P28,Q9HA64,O75718,O60725,P46977 5 +Positive regulation of map kinase activity 0.5953219022746112 1.0624355085044923 0.2880380209812949 1.0 0.8353580043560827 6 P14174 1 +Amyloid beta metabolic process 0.5222165549076438 1.0620739514500297 0.2882021144092923 1.0 0.8353580043560827 10 O95197,Q9NQC3,P15260 3 +Cell activation 0.3313654121168042 1.0619268239403707 0.288268906579364 1.0 0.8353580043560827 116 Q5RKV6,P15260,P14174,Q9Y3I1,P04083,O96028,P10644,P04439,Q16539,Q96FZ2,Q96FV9,P52294,Q92990,P46379,Q12888,P62942,Q8WXW3,Q92542,P09601,P04062,Q9NUQ9,P17931,Q06124,P78318,Q96IZ0,Q07954,P04792,P17812,Q9UQ84,Q9Y624,P42345,P13051 32 +Negative regulation of ion transport 0.46872594585746 1.0615752405056886 0.2884285588387847 1.0 0.8353580043560827 15 P78417,Q06787,P62942,P21796 4 +Bergmann glial cell differentiation 0.6495814445484271 1.060684639488498 0.2888332429586222 1.0 0.8353885260742989 5 Q02750,Q06124 2 +Metencephalon development 0.3947107157471231 1.0592996622308322 0.2894633287427002 1.0 0.8364473845154998 27 Q14103,Q5KU26,Q92542,Q02750,P54802,P04062,P46109,Q06124 8 +Snrna transcription 0.7807829181494648 1.0572716385579142 0.290387633135361 1.0 0.837971963196167 2 Q4G0J3 1 +Snrna transcription by rna polymerase ii 0.7807829181494648 1.0572716385579142 0.290387633135361 1.0 0.837971963196167 2 Q4G0J3 1 +Positive regulation of small gtpase mediated signal transduction 0.7417194711717492 1.0562424984221144 0.2908574391217486 1.0 0.8381042009274633 4 Q15555 1 +Blood vessel endothelial cell migration 0.4298184599395717 1.0543127873369234 0.2917397361685854 1.0 0.8381042009274633 21 P04083,Q8WTV0,P09601,P42785 4 +Transepithelial transport 0.7408252807094152 1.0528406551026688 0.2924140285599006 1.0 0.8381042009274633 4 P08183 1 +Negative regulation of developmental growth 0.5638897871844353 1.0511419838537108 0.2931933841395051 1.0 0.8388110497932479 7 Q8N0X7 1 +Regulation of response to stress 0.3545271433631807 1.0495715743091767 0.2939151318865352 1.0 0.8391044432966052 222 Q96FW1,P16989,P51116,P14174,Q9Y3I1,Q9UKG1,P35637,P04083,O43813,O96028,P43243,Q96G23,P04439,Q16543,Q16539,Q96FV9,P01889,Q9NZ08,P46379,Q12888,O75844,P51114,Q53EL6,P10586,O76024,P29372,O95881,O43765,O15344,Q99873,Q9NUD5,P58107,P49327,Q9NXR7,Q92905,P61978,P08183,P04062,Q96K76,Q99543,Q9BYW2,Q96ST3,Q96KB5,Q06124,Q7L7X3,P67809,P78318,Q06787,O75832,Q07820,Q9H993,Q9H000,Q96IZ0,Q02750,Q06481,P28070,P04792,O94992,P19474,P00374,Q8IXJ6,P60900,O14936,O43657,Q96PK6,P42345 66 +Regulation of mrna processing 0.3247437335896263 1.0494216392446032 0.2939841031110195 1.0 0.8391044432966052 88 P51116,P38159,P22626,Q13242,P31483,Q9UHX1,P51114,Q07666,P51003,Q96ST2,Q96PU8,O43865,Q4G0J3,P52756,P61978,Q9BWF3,Q14011,O75525,Q06787,P98175,P21127,P62995,P98179 23 +Mitotic g2 m transition checkpoint 0.4922100727887011 1.0477114202083118 0.2947715843197938 1.0 0.8397093659994684 12 Q9Y619,Q9NXR7 2 +Peptidyl arginine methylation to asymmetrical dimethyl arginine 0.8280561552844828 1.0449911455573442 0.2960270618756977 1.0 0.8397093659994684 3 Q86X55 1 +Positive regulation of b cell mediated immunity 0.5352175158956805 1.0433388852285748 0.2967913676166496 1.0 0.8397093659994684 9 Q96FZ2,O96028,Q5RKV6,Q12888 4 +Positive regulation of isotype switching 0.5352175158956805 1.0433388852285748 0.2967913676166496 1.0 0.8397093659994684 9 Q96FZ2,O96028,Q5RKV6,Q12888 4 +Regulation of cell activation 0.3519145549857381 1.0422570717098525 0.2972925093367502 1.0 0.8397093659994684 57 Q8WXW3,Q5RKV6,Q9Y624,P14174,Q9Y3I1,Q96FV9,Q96FZ2,Q92990,Q96IZ0,P09601,P04083,O96028,P10644,Q06124,Q9NUQ9,P17931,P04439 17 +Tricarboxylic acid metabolic process 0.5348780131694799 1.0416208203813422 0.2975875118633508 1.0 0.8397093659994684 9 P48735 1 +Protein localization to microtubule end 0.7765124555160293 1.040082592236118 0.2983015304518219 1.0 0.8397093659994684 2 Q15555 1 +Lipid biosynthetic process 0.3327685841522318 1.0392474340314963 0.2986896751305565 1.0 0.8397093659994684 122 P30536,O75874,P14174,Q15392,O76054,Q10713,P48449,P04083,Q96N66,Q15800,Q9BY49,Q96G23,Q8WTV0,Q8NF37,Q9UKR5,Q9NPH0,P37268,Q8WXW3,Q16850,Q96PU8,O15270,O00116,Q8NCC3,P04062,P35790,Q14739,Q9Y217,Q06136,Q14534,Q99943,Q8NBX0,P42356,Q9H7Z7,P42345 34 +Macropinocytosis 0.8263370048138842 1.038782676633189 0.2989058198219185 1.0 0.8397093659994684 3 Q06481 1 +Detection of abiotic stimulus 0.5612530563379967 1.038722927881104 0.2989336147416424 1.0 0.8397093659994684 7 P30419,Q15555 2 +Positive regulation of epithelial cell migration 0.3908863433777108 1.037861213538417 0.2993346732266089 1.0 0.8397093659994684 29 Q9NQC3,Q8WTV0,Q15555,P04792,P09601,P04083,P07737,Q13685,P42345 9 +Negative regulation of receptor signaling pathway via jak stat 0.8259166963332196 1.0372654222439126 0.29961217581423 1.0 0.8397093659994684 3 O14964,Q8WXW3 2 +Negative regulation of receptor signaling pathway via stat 0.8259166963332196 1.0372654222439126 0.29961217581423 1.0 0.8397093659994684 3 O14964,Q8WXW3 2 +Calmodulin dependent kinase signaling pathway 0.8257343191281316 1.0366071441305955 0.2999189824590282 1.0 0.8397093659994684 3 O75844 1 +Negative regulation of response to endoplasmic reticulum stress 0.4999413781180554 1.0355476859252408 0.3004132086926923 1.0 0.8397093659994684 11 O95881 1 +Intracellular protein transport 0.338066393523336 1.0350159956174496 0.3006614411400488 1.0 0.8397093659994684 291 P30536,P55735,Q9NS69,Q9Y282,Q99595,O60830,P57740,Q5JRX3,Q16543,O00505,Q9Y512,Q92973,O00629,P52294,P46379,O15260,O14737,Q15629,O60684,Q9Y4C2,O43765,Q8TCT9,P10619,Q92783,O60725,O43865,Q9P2W9,Q9UHB9,Q99523,Q14108,Q9BW83,Q06124,P30419,Q9Y679,P31751,O14964,Q8N4H5,Q06481,Q15437,Q15904,Q9Y2T2,Q92572,P43307 43 +Microglial cell activation 0.7750889679715475 1.0343613711772104 0.300967256038027 1.0 0.8397093659994684 2 P15260 1 +Isoprenoid metabolic process 0.4348943024292258 1.0329022026090893 0.3016496679121689 1.0 0.8397093659994684 20 P61916,Q9HB40,Q07954,P29375,P48449,P51648,Q9BY49 7 +Amyloid beta formation 0.546854580507751 1.03268497869205 0.301751345412645 1.0 0.8397093659994684 8 O95197,Q9NQC3,P15260 3 +Cerebellar purkinje cell layer development 0.5598915672386894 1.032312111310905 0.3019259292090348 1.0 0.8397093659994684 7 P54802 1 +Positive regulation of exosomal secretion 0.5467745686415901 1.0322947838195646 0.3019340439134717 1.0 0.8397093659994684 8 O14964,Q92783,O43633 3 +Negative regulation of viral transcription 0.8244927020291962 1.0321268757357198 0.302012685115316 1.0 0.8397093659994684 3 P19474,Q4G0J3 2 +Regulation of map kinase activity 0.4595241564196718 1.032095001916977 0.3020276150329701 1.0 0.8397093659994684 16 O14964,Q15750,P14174,P04062 4 +Suppression of viral release by host 0.7352540998644364 1.031665969840293 0.3022286244315846 1.0 0.8397093659994684 4 P19474 1 +Somatic diversification of immunoglobulins 0.4346698640843371 1.0313313155995387 0.3023854778618884 1.0 0.8397093659994684 20 Q5RKV6,P52701,Q96FZ2,Q96FV9,Q12888,O96028,Q9UQ84,Q8WYA6,P13051 9 +Extrinsic apoptotic signaling pathway 0.3869199178679308 1.0306872603045465 0.302687500856849 1.0 0.8398120371846989 32 P61289,Q07820,P42858,P62136,Q9NR28,P30153,Q14247,P09601,Q99523,P17931,P30154 11 +Positive regulation of monooxygenase activity 0.7347461774059673 1.0297372944804786 0.3031333434638781 1.0 0.8403132097684145 4 Q8WTV0 1 +Cell migration involved in sprouting angiogenesis 0.5878581009091343 1.0292234478334417 0.3033746863290691 1.0 0.840614511266861 6 P09601 1 +Pigment metabolic process 0.3908817775622229 1.0278900848573285 0.3040015341015984 1.0 0.8408348777476528 27 P30536,P30519 2 +Adult behavior 0.4537986540945645 1.0276423666677068 0.3041180874049622 1.0 0.8408348777476528 17 O75844,P50897 2 +Mitophagy 0.4884147789241321 1.0262052619469235 0.3047948416152897 1.0 0.8408348777476528 12 Q16543,P21796 2 +Response to hepatocyte growth factor 0.7337493131801199 1.0259529372207965 0.3049137681969553 1.0 0.8408348777476528 4 Q9UKG1,Q06481 2 +Negative regulation of cell substrate adhesion 0.55822969826532 1.024488755839567 0.3056044790858385 1.0 0.8423730247790164 7 O14936,O43707 2 +Cellular senescence 0.4169768329205937 1.0215220504166695 0.3070071674969852 1.0 0.8437534931514775 22 O75844,P67809,P45985,Q96IZ0 4 +Regulation of cellular carbohydrate catabolic process 0.5859755445873056 1.0208535250921236 0.3073238408079466 1.0 0.8437534931514775 6 Q14108 1 +Positive regulation of proteolysis involved in cellular protein catabolic process 0.3799341208718177 1.02031330429772 0.3075798955682913 1.0 0.8437534931514775 37 O43765,Q06787,O75832,Q9H000,P46379,Q96HY6,P04062,Q8IXJ6,P53634,Q9UBS8 10 +Ventricular cardiac muscle tissue development 0.5571824220062047 1.0195597521081647 0.3079373013093667 1.0 0.8437534931514775 7 O75844,Q14126,P62942 3 +Regulation of phagocytosis 0.4655182632463419 1.018603238302226 0.3083913662934179 1.0 0.8437534931514775 14 Q9UKG1,Q8WTV0,Q06481 3 +Intestinal absorption 0.5569521862318255 1.0184762689555602 0.3084516729642497 1.0 0.8437534931514775 7 Q8WTV0 1 +Regulation of reactive oxygen species metabolic process 0.3896669423643233 1.017929012460708 0.3087116928062623 1.0 0.8437534931514775 27 P30536 1 +Regulation of calcium ion transport into cytosol 0.5135316829954029 1.0162847222658504 0.3094938216892857 1.0 0.8437534931514775 10 P78417,P42858 2 +Regulation of release of sequestered calcium ion into cytosol 0.5135316829954029 1.0162847222658504 0.3094938216892857 1.0 0.8437534931514775 10 P78417,P42858 2 +Negative regulation of response to biotic stimulus 0.4245087424245611 1.0161734428339246 0.309546800514844 1.0 0.8437534931514775 21 P01889,P78540,Q7Z739,P19474,Q8IXJ6,Q9UIV1,O43657,P04439 8 +Regulation of biological process involved in symbiotic interaction 0.5564417610641861 1.0160743821221765 0.3095939671922814 1.0 0.8437534931514775 7 P19474 1 +Regulation of histone modification 0.3543395780372189 1.0146698379318704 0.3102632364776756 1.0 0.8437534931514775 53 Q9NWY4,Q01105,Q06787,Q96FW1,Q96ST2,Q5VTR2,P29375,Q969T9,O43823,Q9ULX6,Q96ST3,Q03164,O75844 13 +Hepatocyte differentiation 0.7697508896797285 1.0129464218097228 0.3110857532763176 1.0 0.8449851772447599 2 P04083 1 +Positive regulation of leukocyte cell cell adhesion 0.4395286011539846 1.011344891324801 0.3118513872688493 1.0 0.8457392233257445 19 Q9NUQ9,Q06124,P04439 3 +Glycerolipid biosynthetic process 0.3788158714249409 1.0100922631001512 0.3124510886482314 1.0 0.8457392233257445 37 Q8WTV0,Q8NF37,Q9Y217,Q9NPH0,Q8NCC3,Q99943,P42356,P35790 8 +B cell mediated immunity 0.4508739451689325 1.00872214890217 0.3131079063876347 1.0 0.8457392233257445 17 Q5RKV6,P52701,Q96FZ2,Q96FV9,Q12888,O96028,Q9UQ84,P13051 8 +Macromolecule deacylation 0.3779045979887659 1.008386125088892 0.3132691312343449 1.0 0.8457392233257445 38 P50897,Q92769,P29375,Q9ULX6,O43823,O95983,Q96ST3,Q8IXJ6,Q9NUJ1,Q96PK6,Q9UMR5 11 +Demethylation 0.4599715504650351 1.007588376984468 0.3136521110884911 1.0 0.8457392233257445 15 Q8NB78,Q9NRW3,P29375,Q16850 4 +Peptidyl arginine methylation 0.7288745758232646 1.0074654158567469 0.3137111691878633 1.0 0.8457392233257445 4 Q99873,Q86X55 2 +Peptidyl arginine n methylation 0.7288745758232646 1.0074654158567469 0.3137111691878633 1.0 0.8457392233257445 4 Q99873,Q86X55 2 +Macroautophagy 0.3150514834089418 1.003268144452964 0.3157315017292941 1.0 0.8481166986023775 94 Q16543,Q9Y679,Q92783,P42858,Q9Y487,O14964,Q93050,P21796,O15270,P09601,O15118,Q8NHS3,P04062,P36543 14 +Protein targeting to membrane 0.386574338759274 1.001762091138605 0.3164585102342458 1.0 0.8486659243988219 29 O43765,P31751,O60725,P46379,Q15629,P43307,Q9Y4C2 7 +Regulation of mitochondrial membrane potential 0.4377318821382078 0.999090428905158 0.3177508872036449 1.0 0.8499437118528739 19 P30536,Q8N0X7 2 +Protein k11 linked ubiquitination 0.5261857318617242 0.9976625108404796 0.3184430378457703 1.0 0.8501000778593292 9 Q9UJX4,Q9UJX6,Q13042,Q9UJX3,Q9H1A4,Q9UJX2 6 +Positive regulation of smooth muscle cell apoptotic process 0.634288072545784 0.9976091423661756 0.3184689261224629 1.0 0.8501000778593292 5 P98175,P45985 2 +Protein dephosphorylation 0.347636806866892 0.9969978363919252 0.3187655601452102 1.0 0.8503037008515295 55 Q12972,P17931,Q9Y217,P62136,P42858,P30153,Q86XL3,Q92797,Q5H9R7,Q15750,O00743,P62942,Q06124,P04062,P42345,P30154 16 +Positive regulation of leukocyte mediated immunity 0.4214538585692528 0.9942502138134376 0.3201010672396909 1.0 0.8513365482205126 21 Q9NUQ9,Q96FZ2,O96028,P04439 4 +Negative regulation of fat cell differentiation 0.5798566829186258 0.9936723296407324 0.3203824181264538 1.0 0.8513365482205126 6 Q8N4Q0,Q99523 2 +Response to ketone 0.3780560954194805 0.993203143357987 0.3206109668134946 1.0 0.8513365482205126 35 P30536,P16278,Q14103,Q6PKG0,P40818,O95831,Q969T9,O43823,Q13126,P16435,Q9H7B4,P04062,Q96ST3,P49321,Q96C86 15 +Macrophage migration 0.7250466981827164 0.9929706311420124 0.3207242669791337 1.0 0.8513365482205126 4 P14174,Q9BW27 2 +Macrophage chemotaxis 0.7250466981827164 0.9929706311420124 0.3207242669791337 1.0 0.8513365482205126 4 P14174,Q9BW27 2 +Regulation of stress activated protein kinase signaling cascade 0.3956701994102298 0.9905885419408248 0.3218865348849056 1.0 0.851759924681562 24 O15344,P29372,P78318,Q99873,Q96KB5,Q02750,P49327,O75844,Q53EL6,Q7L7X3 10 +Positive regulation of gene expression 0.3510642540171053 0.9904416320197856 0.3219583050021801 1.0 0.851759924681562 206 Q9H2J4,Q9H074,Q5RKV6,P15260,P16989,P51116,P14174,P08670,P38159,Q9UKG1,P35637,P04083,O96028,Q567V2,O75312,Q9BRP8,P04439,Q01650,P11940,Q96FZ2,O14737,O75844,O60684,P51114,Q07666,Q92804,O60506,Q8WXW3,Q9NUD5,Q969T9,P09601,Q71RC2,Q99729,Q9BYW2,Q9NUQ9,Q14011,Q06124,Q14103,P67809,Q06787,P98175,O14964,Q96IZ0,Q02750,P62995,Q99943,P98179,Q96I24,Q9Y2R0 49 +Positive regulation of oligodendrocyte differentiation 0.7241008028328002 0.9893920915310452 0.322471342361351 1.0 0.851759924681562 4 P42345,Q92769 2 +Embryonic hemopoiesis 0.8119514646719449 0.9870048300199968 0.3236402707717352 1.0 0.8531232927955432 3 Q03164 1 +Cell aging 0.3831652006918013 0.9798909845945154 0.3271399336032727 1.0 0.8558093268151094 30 P67809,P45985,P14174,Q96IZ0,Q02750,O75844 6 +Positive regulation of neuron projection development 0.4112822188215219 0.9795527885920848 0.3273069190688051 1.0 0.8558093268151094 22 Q14108,Q9UQB8 2 +Anaphase promoting complex dependent catabolic process 0.5062759065732877 0.9780812056370798 0.3280341624725418 1.0 0.8558093268151094 10 Q9UJX4,Q13042,Q9UJX3,Q9H1A4,Q9UJX2 5 +Bradykinin catabolic process 0.7210357599630071 0.9778054956353692 0.3281705324539554 1.0 0.8558093268151094 4 P42892 1 +Positive regulation of oxidoreductase activity 0.5478932776038087 0.9758854383033028 0.3291212389917679 1.0 0.8566638351168195 7 Q8WTV0 1 +Positive regulation of dephosphorylation 0.4581763410946646 0.97439920957544 0.329858361793536 1.0 0.8572398193524629 14 Q92797,Q86XL3,P04062 3 +Positive regulation of endothelial cell migration 0.4340214269347142 0.9738026433303686 0.3301545403876267 1.0 0.8572398193524629 19 Q8WTV0,P09601,Q13685 3 +Meiosis ii cell cycle process 0.7597864768683256 0.9731522239704576 0.3304776516771448 1.0 0.8572398193524629 2 P30153 1 +Meiotic sister chromatid cohesion centromeric 0.7597864768683256 0.9731522239704576 0.3304776516771448 1.0 0.8572398193524629 2 P30153 1 +Glycolipid transport 0.8075125367319638 0.971096459566016 0.3315002466846495 1.0 0.8585107876419052 3 P07602 1 +Acute phase response 0.7590747330961034 0.9703194066618958 0.3318873068457231 1.0 0.8585107876419052 2 Q9BQE5 1 +Mitochondrial proton transporting atp synthase complex assembly 0.758718861209964 0.9689035018102242 0.3325933381191222 1.0 0.8585107876419052 2 Q5TC12 1 +Positive regulation of receptor mediated endocytosis 0.5198009934485887 0.9654207692644972 0.3343341028487412 1.0 0.860900125864475 9 P61978,P50897 2 +Regulation of heart contraction 0.4172303612811592 0.9639717143648814 0.3350601072312629 1.0 0.8610762110512492 21 O75844,P78417 2 +Regulation of inflammatory response 0.3824321925457693 0.9621322832305108 0.3359831593482043 1.0 0.8610762110512492 28 Q16539,Q9H000,Q99496,P28070,P04083,Q9UNH7,P04062,Q96KB5,P53634,P60900,Q53EL6 11 +Urea metabolic process 0.756583629893255 0.960415219526456 0.3368462812957506 1.0 0.8610762110512492 2 Q9Y619 1 +Urea cycle 0.756583629893255 0.960415219526456 0.3368462812957506 1.0 0.8610762110512492 2 Q9Y619 1 +Negative regulation of type 2 immune response 0.7565836298932527 0.960415219526446 0.3368462812957558 1.0 0.8610762110512492 2 P04083 1 +Type 2 immune response 0.7565836298932527 0.960415219526446 0.3368462812957558 1.0 0.8610762110512492 2 P04083 1 +Negative regulation of defense response to bacterium 0.7565836298932369 0.9604152195263844 0.3368462812957866 1.0 0.8610762110512492 2 Q8IXJ6 1 +Regulation of defense response to bacterium 0.7565836298932369 0.9604152195263844 0.3368462812957866 1.0 0.8610762110512492 2 Q8IXJ6 1 +Positive regulation of protein export from nucleus 0.5319277918149765 0.959993398079268 0.3370585376161901 1.0 0.8610762110512492 8 P50402,Q9Y3B8,Q9NW64 3 +Positive regulation of cholesterol metabolic process 0.7562277580071182 0.9590017108957768 0.3375578832874499 1.0 0.8610762110512492 2 P16435 1 +Positive regulation of alcohol biosynthetic process 0.7562277580071182 0.9590017108957768 0.3375578832874499 1.0 0.8610762110512492 2 P16435 1 +Positive regulation of cholesterol biosynthetic process 0.7562277580071182 0.9590017108957768 0.3375578832874499 1.0 0.8610762110512492 2 P16435 1 +Nadp metabolic process 0.4554377010154875 0.9579361252649148 0.3380949686937153 1.0 0.8613188617170964 14 P48735 1 +Regulation of actin cytoskeleton reorganization 0.5310087530272065 0.9555261291313653 0.3393116982225854 1.0 0.8622412156481699 8 Q9UQB8 1 +Regulation of fibroblast migration 0.5177762292165332 0.9552066638009716 0.3394731965727797 1.0 0.8622412156481699 9 Q06481 1 +Response to xenobiotic stimulus 0.3429471167862358 0.951359299361362 0.3414220139635504 1.0 0.8664762925458627 64 P30536,P07099,P78417,P09601,P21266,O15118,P08183,O43169 8 +Gland development 0.3437540847879068 0.9500742459234812 0.3420745282488995 1.0 0.8665593332054692 59 P30536,Q14103,Q9NQC3,P07602,P11717,P31751,Q13505,P09601,P04083,O75844 10 +Circadian regulation of gene expression 0.4304776785880085 0.949679339528395 0.3422752108274087 1.0 0.8665593332054692 19 P62136,Q03164,P29375,P43490 4 +Regulation of cytoplasmic translational elongation 0.7537366548042734 0.9491169880939464 0.342561115142433 1.0 0.8669368157578268 2 P49588 1 +Digestive system process 0.5006312216422254 0.9484060882484208 0.342922761193035 1.0 0.8671594324342629 10 Q8WTV0 1 +Postsynaptic signal transduction 0.7118693322872502 0.9432439791885388 0.3455561229423551 1.0 0.870693709004173 4 P52294 1 +Regulation of anion transport 0.4736880366031986 0.9429242773614436 0.3457196361195349 1.0 0.870693709004173 12 P14174,P08183,Q9Y4C2,Q7L0J3 4 +Blastoderm segmentation 0.7996040555919395 0.942843695372317 0.3457608579798588 1.0 0.870693709004173 3 Q8N2A8 1 +Tripartite regional subdivision 0.7996040555919395 0.942843695372317 0.3457608579798588 1.0 0.870693709004173 3 Q8N2A8 1 +Regulation of catabolic process 0.3379333156508188 0.9408040382657642 0.3468052910675812 1.0 0.870693709004173 278 P30536,Q9Y3I1,P21796,Q8NHS3,Q9UBS8,Q16539,Q8WTV0,Q9Y487,O95831,Q14247,P46379,O75844,P51114,P21283,Q92804,P36404,P10619,P61289,Q16850,Q92615,P09601,O15514,O15118,Q9Y2L1,Q14108,Q9UNH7,P04062,Q9HCE1,Q8IYB8,Q14011,O00429,P07602,P19474,Q9H2J4,O75874,P16989,P51116,P35637,P36543,Q969T7,Q93050,Q92945,O43765,O60506,O15270,P67809,P98175,Q07820,P42858,P31751,O14964,Q9H074,Q96B26,Q13310,Q08J23,Q8TEY7,Q8NF37,Q86VM9,Q99729,Q14103,Q06787,O75832,Q9H000,Q07954,Q96C86,P62136,P08670,Q9C0B1,P11940,Q9Y5X3,Q92990,Q14671,Q96KB5,Q9Y2S7,Q9UJX6,P40818,P04792,Q9UL46,Q8IXJ6,P61421,P42345 81 +Regulation of ion transport 0.3355157029340384 0.9374405469763816 0.3485319922551304 1.0 0.8712612366551328 74 P30536,P42858,O43865,P14174,P78417,P21796,P62942,P08183,O75844,O14936,Q9Y4C2,Q7L0J3 12 +Protein heterooligomerization 0.5394938188849346 0.9364821930506584 0.3490249766352815 1.0 0.8714943606886822 7 Q9Y285,P23921,Q8N684,P31350 4 +Activation of immune response 0.3650732638170326 0.9355207657916506 0.3495199867352578 1.0 0.8714943606886822 43 Q9NUD5,Q96IZ0,P46379,Q06481,Q9UKG1,O94992,Q96ST3,Q96PK6,P46109,Q07666,P17931,P04439 12 +Cardiac epithelial to mesenchymal transition 0.7974368102527606 0.9351226218234427 0.3497251095672429 1.0 0.8714943606886822 3 Q53EL6,Q9NQC3 2 +Gpi anchor metabolic process 0.6184449917745224 0.932573219003285 0.3510403661769465 1.0 0.872202311545068 5 O60762,Q96S52,O43292 3 +Positive regulation of b cell activation 0.481142946532868 0.932238434075682 0.3512133168890134 1.0 0.872202311545068 11 Q5RKV6,Q96FZ2,P14174,Q12888,O96028 5 +Lysosomal transport 0.3686850746296826 0.9304926285096072 0.3521160790441597 1.0 0.8729888861122224 39 P07602,P11717,O14976,O14964,Q99523,O15118,Q14108,Q9Y2T2 8 +Regulation of viral transcription 0.6176932241158455 0.929496971581512 0.352631593954082 1.0 0.8731269711474703 5 P19474,Q4G0J3 2 +Dna dealkylation involved in dna repair 0.7953008187967301 0.9275223199039794 0.3536554086618817 1.0 0.8731269711474703 3 Q8N3C0,Q9C0B1 2 +Regulation of cellular response to insulin stimulus 0.4496664907123728 0.92329931407996 0.3558512452459426 1.0 0.8764202647196029 14 Q9Y5X3,Q9BZF1,Q06481,Q06124 4 +Regulation of golgi organization 0.6154009703202082 0.9201231982257 0.3575083828598329 1.0 0.8773464137825353 5 Q02750,Q9P2W9 2 +Cytokine production involved in inflammatory response 0.5105658482617726 0.9188832869985184 0.3581566225990924 1.0 0.8773464137825353 9 Q16539,Q8IV08,Q06481,Q9UKG1,O60684,Q53EL6 6 +Folic acid metabolic process 0.6150972914798951 0.9188820685783662 0.3581572599665215 1.0 0.8773464137825353 5 Q9H2D1 1 +Mitotic chromosome condensation 0.4786539893194544 0.918601568678309 0.3583040111833993 1.0 0.8773464137825353 11 Q9ULX6 1 +Glial cell differentiation 0.3696937806346105 0.9181911187205928 0.3585188174937441 1.0 0.8775333126527063 35 Q15022,P15260,Q92769,P31751,Q92542,P08670,Q02750,P04062,Q8IXJ6,Q07954,P42345,Q06124 12 +Gastrulation with mouth forming second 0.7047793815243525 0.9166136516386284 0.3593451281415483 1.0 0.8784861317099603 4 Q4VCS5 1 +Organonitrogen compound catabolic process 0.3124011925435482 0.916389564284272 0.359462606836662 1.0 0.8784861317099603 331 Q15369,Q99829,Q9H2J4,Q9NRW3,P55786,Q13126,P21964,P49721,Q8NHS3,O75503,P08236,P06865,Q6P179,Q9UIQ6,Q9UPU5,O60502,P30519,P07858,P16278,P09960,Q8TEY7,Q8WTV0,P25788,Q8NF37,P28072,P46379,P06280,Q9UHG3,O75844,Q8N511,P49720,O43765,Q8TCT9,P10619,P50897,Q16850,P28074,Q92783,Q99436,Q9H773,P09601,P23378,P54802,Q8NCC3,P42892,P04062,Q96K76,Q9NUJ1,Q9UJX3,Q16740,Q9Y679,Q06787,O14773,O75832,P20618,Q9H000,O14964,Q8N3C0,P28070,Q07954,P60900,P17900,Q96RU2 63 +Negative regulation of dna binding 0.5098836341156455 0.9154510420762494 0.3599548929898624 1.0 0.8792624725122158 9 Q99829,Q96ST3,P09601 3 +Leukotriene metabolic process 0.7044169712881085 0.9152550050430052 0.3600577743678712 1.0 0.8792624725122158 4 Q14914 1 +Organelle disassembly 0.3667645371463332 0.912684761761688 0.3614083605194409 1.0 0.881217336885908 39 P30536,P21796,P42858,P04062 4 +Regulation of cell cycle g1 s phase transition 0.3720139173602299 0.9123920928272312 0.3615623504954992 1.0 0.881217336885908 33 O75179,Q9Y3I1,Q06481,Q9UKG1,P04083,Q9UL46,Q8N6R0,Q96DY7,P31350 9 +Motor neuron apoptotic process 0.7906728373086562 0.9110882412197516 0.3622488815824192 1.0 0.881217336885908 3 P45985,O75312 2 +Negative regulation of translational initiation 0.521632327161791 0.9100228090712242 0.3628104809497656 1.0 0.8819064126500441 8 Q9BWF3,Q9BPZ3,Q06787 3 +Multicellular organismal signaling 0.4096159825035584 0.9095030702714914 0.363084637890656 1.0 0.8819221703606402 21 Q06787,Q12955,P04062,O75844,P42345 5 +Regulation of cation channel activity 0.4399785411352364 0.9090391495713488 0.3633294608422828 1.0 0.8819221703606402 16 P78417,Q06787,P62942,P42858 4 +Cytokine production involved in immune response 0.4931117226829151 0.908955445288071 0.3633736447548732 1.0 0.8819221703606402 10 P04439,P14174,P09601 3 +Negative regulation of lipase activity 0.7899608401566481 0.9085640766335636 0.3635802761406588 1.0 0.8820858384009781 3 P04083,Q99523 2 +Peripheral nervous system development 0.5074703264381337 0.9033165525169 0.3663579140216497 1.0 0.8842753051043015 9 P21266,P51648,P31751 3 +Regulation of cell shape 0.3755926070108474 0.902794498213256 0.366634971674276 1.0 0.8842753051043015 27 O75844,Q9Y624,Q9UQB8 3 +Cerebellar cortex morphogenesis 0.5321859074222955 0.9022878758537408 0.3669039643687783 1.0 0.8842753051043015 7 Q06124,P04062 2 +Nuclear pore complex assembly 0.5071957914429386 0.9019368571733424 0.3670904109421244 1.0 0.8842753051043015 9 P57740,Q9BTX1,Q9NQC3 3 +Vascular transport 0.4563860116525858 0.9008248515633036 0.3676814519694527 1.0 0.8842753051043015 13 Q07954,P53985,P08183 3 +Signaling receptor ligand precursor processing 0.7875569266156114 0.9000501783380374 0.3680935478652589 1.0 0.8842753051043015 3 P42892 1 +Negative regulation of vascular associated smooth muscle cell proliferation 0.6104382398733881 0.8998624587796474 0.3681934506037747 1.0 0.8842753051043015 5 P09601 1 +Regulation of oligodendrocyte differentiation 0.5314850620973107 0.8990135731335388 0.3686454309757854 1.0 0.8842753051043015 7 Q92769,P42345 2 +Deadenylation dependent decapping of nuclear transcribed mrna 0.7409252669039179 0.8985708199969585 0.3688813072251586 1.0 0.8842753051043015 2 Q96C86 1 +Peptidyl arginine modification 0.5582689511646965 0.8981667707057802 0.369096645955477 1.0 0.8842753051043015 6 Q99873,Q86X55 2 +Mechanoreceptor differentiation 0.5064260456061258 0.8980692432323472 0.3691486350921784 1.0 0.8842753051043015 9 O60443,P54802 2 +Meiosis i cell cycle process 0.4334909547792208 0.8966347640977507 0.3699138413467548 1.0 0.8842753051043015 17 Q92791,O60216,Q9BTX1,P46379 4 +Glycosyl compound metabolic process 0.3747906402457574 0.8962545633867183 0.3701168201241658 1.0 0.8842753051043015 27 O60725,Q9BTY2,Q13126,P08236,P04062,Q9NUJ1 6 +Cytoplasmic pattern recognition receptor signaling pathway in response to virus 0.465387813891544 0.8961607328683019 0.3701669243189267 1.0 0.8842753051043015 12 Q9NUD5,O75179,O43657,Q14671 4 +Carbohydrate homeostasis 0.3662400557354321 0.8953937240624733 0.3705766543586639 1.0 0.8842753051043015 37 P53985,Q06124,P42785 3 +Regulation of lipid localization 0.4076301410660923 0.8953285806202903 0.3706114664400242 1.0 0.8842753051043015 21 P30536,Q8WTV0,P31751,P14174,O15260,Q06124 6 +Cellular response to exogenous dsrna 0.6989647625209765 0.8948474311874317 0.3708686513369117 1.0 0.8842753051043015 4 Q9NUD5 1 +Isotype switching to iga isotypes 0.7860462586641981 0.8947066442343065 0.3709439259888547 1.0 0.8842753051043015 3 O96028 1 +Respiratory system development 0.4074609749058271 0.8941217858781657 0.3712567341009416 1.0 0.8842753051043015 21 P46379,Q15750,Q02750,P09960 4 +Cranial skeletal system development 0.5053516188433187 0.892672759103591 0.3720324425243682 1.0 0.8842753051043015 9 Q9BYW2,Q53EZ4 2 +Toll like receptor 4 signaling pathway 0.785437840310788 0.8925560485431608 0.372094964958447 1.0 0.8842753051043015 3 Q06481 1 +Regulation of toll like receptor 4 signaling pathway 0.785437840310788 0.8925560485431608 0.372094964958447 1.0 0.8842753051043015 3 Q06481 1 +Cellular response to vitamin 0.6084858801461003 0.8919050705498012 0.3724438166207036 1.0 0.8842753051043015 5 Q96C86 1 +Cellular component maintenance 0.4897162738031421 0.8911776981592885 0.3728338468309344 1.0 0.8842753051043015 10 Q8IUD2,Q07157,Q96S97 3 +Regulation of t cell proliferation 0.4371132844625921 0.8910809558866277 0.3728857408408754 1.0 0.8842753051043015 16 P02786,Q96IZ0,Q92990,P04083,P10644,P17931,P04439 7 +Regulation of fc receptor mediated stimulatory signaling pathway 0.6979318138870594 0.890988160049257 0.3729355221272801 1.0 0.8842753051043015 4 Q06481 1 +Fc receptor mediated stimulatory signaling pathway 0.6979318138870594 0.890988160049257 0.3729355221272801 1.0 0.8842753051043015 4 Q06481 1 +Aorta morphogenesis 0.6977677068686666 0.8903752413995503 0.3732644320482312 1.0 0.8842753051043015 4 Q07954,Q96AY3 2 +Histone h4 r3 methylation 0.7384341637010634 0.8888027044282371 0.3741091221823849 1.0 0.8842753051043015 2 Q99873 1 +Synapse maturation 0.7843468413708785 0.88870184488564 0.3741633393295094 1.0 0.8842753051043015 3 P07737 1 +Negative regulation of cell cycle process 0.3371901640295246 0.8881480256664027 0.3744611320055151 1.0 0.8842753051043015 65 Q16539,Q7L7X3,Q13564,Q96RU2,Q96FV9,Q9Y3I1,O60216,Q12888,Q9Y619,Q9NXR7,Q08J23,Q06124,Q8N6R0,Q96DY7,Q96PK6,O43670,Q96K76 17 +Centromeric sister chromatid cohesion 0.6075084220918637 0.8879241160939866 0.3745815714258973 1.0 0.8842753051043015 5 P49711,P30153,O60566 3 +T cell proliferation 0.3983588366875715 0.8846235513954452 0.3763597000391652 1.0 0.8854310430000287 22 P02786,Q92542,Q96IZ0,Q92990,P17812,P04083,P10644,P17931,P04439 9 +Cellular response to ether 0.7366548042704628 0.8818382902342488 0.3778642619846852 1.0 0.8862679557966314 2 Q6PKG0 1 +Positive regulation of fibroblast proliferation 0.554437795672284 0.8813007499367783 0.3781550603035377 1.0 0.8862679557966314 6 P14174 1 +Respiratory chain complex iii assembly 0.7820062427238573 0.8804427512283531 0.3786195055681767 1.0 0.8863360941209959 3 Q6DKK2 1 +Phenol containing compound metabolic process 0.4872072029727536 0.8780573919792046 0.379912573958217 1.0 0.888378590838827 10 P21964,P07858 2 +Response to nicotine 0.6942753590186888 0.8773459093954824 0.3802987832725788 1.0 0.888695215512407 4 P09601 1 +Icosanoid transport 0.7809345656804416 0.8766656518569955 0.3806682684161795 1.0 0.888695215512407 3 P14174 1 +Regulation of peptidase activity 0.3340730153795211 0.8736707354469845 0.3822975924043563 1.0 0.8913244455726292 69 P30086,P25788,Q9NR28,Q15392,Q06481,O14737,Q96K76,P07858 8 +Signal release 0.3512031602320443 0.8724123786679246 0.3829834498882372 1.0 0.8923115024157477 48 Q06787,P50897,Q7L0J3,Q16836,P14174,P04083,O95721,P53985,O14936,Q06124 10 +Cellular response to abiotic stimulus 0.3368859304490171 0.8723773182619147 0.3830025700758772 1.0 0.8923115024157477 59 P30536,P30419,Q06787,Q15555,P45985,P16989,P31751,Q9NXR7,O75844,Q9Y624,Q96K76 11 +Positive regulation of epithelial to mesenchymal transition 0.6909186761153969 0.864848978412994 0.3871216845745762 1.0 0.8942482500346856 4 Q92769 1 +Transmembrane receptor protein serine threonine kinase signaling pathway 0.3615854990713646 0.8647511993273438 0.3871753613143534 1.0 0.8942482500346856 39 Q16539,Q07954,P08670,Q8N0X7,Q06481,Q9UKG1,Q15750,P62942,Q9UIQ6,Q06330,Q53EL6,Q96PK6,Q92896 13 +Negative regulation of muscle organ development 0.7772973671170125 0.8638677977575716 0.3876605185621362 1.0 0.8942482500346856 3 P16989 1 +Negative regulation of muscle tissue development 0.7772973671170125 0.8638677977575716 0.3876605185621362 1.0 0.8942482500346856 3 P16989 1 +Positive regulation of endocytosis 0.4106061962013211 0.8635656619214719 0.3878265342113602 1.0 0.8942482500346856 20 Q06787,P50897,Q06481,P61978,Q07954 5 +Negative regulation of protein modification by small protein conjugation or removal 0.3673869597490445 0.8620083859531921 0.3886829031590304 1.0 0.8942482500346856 32 P30536,P19474 2 +Regulation of protein serine threonine kinase activity 0.3483691919131626 0.8616930485807935 0.3888564518858257 1.0 0.8942482500346856 49 Q16543,O75832,P42858,P14174,Q9Y3I1,O14964,Q02750,O94992,Q15750,P04062,Q53EL6,Q7L7X3 12 +Regulation of tor signaling 0.4682212666400829 0.861594123918329 0.3889109056723145 1.0 0.8942482500346856 11 O75844,P04062 2 +Regulation of membrane potential 0.3444482901606718 0.8612423842627783 0.389104560866631 1.0 0.8942482500346856 51 P30536,P31751,Q8N0X7,Q14168,Q9UQB8,P04062,O75844 7 +Cop9 signalosome assembly 0.7313167259786495 0.8610114030479268 0.3892317627261321 1.0 0.8942482500346856 2 Q99627 1 +Histone h3 k36 methylation 0.6898651741656887 0.8609322828028992 0.3892753402353812 1.0 0.8942482500346856 4 Q9BYW2,O96028 2 +Rna catabolic process 0.3212690763304076 0.8605635169298643 0.3894784866807215 1.0 0.8942482500346856 123 Q9H074,Q5RKV6,Q96B26,P16989,P51116,P08670,Q13310,P35637,Q08J23,O75312,Q9C0B1,Q9BRP8,P11940,O00584,Q969T7,Q92945,Q86VM9,P51114,Q92804,O60506,Q12972,Q6PGP7,Q99729,Q14011,Q14103,P67809,Q06787,P98175,Q96C86 29 +Intracellular transport 0.2700451607412849 0.8591651706905273 0.3902493960684361 1.0 0.8943554331908754 488 P30536,P55735,Q9NS69,Q9Y282,Q99595,O60830,Q8TD16,P45880,O75503,Q08J23,O75964,Q5JRX3,P57740,P22626,P39687,Q16543,O00505,Q9Y512,Q92973,O00629,P52294,P46379,Q8IUD2,O15260,O14737,Q15629,O75844,O60684,Q9UBX3,Q9Y4C2,Q07666,O43765,Q8TCT9,P10619,Q92783,P11717,O60725,O43865,O43772,Q9P2W9,Q9UHB9,Q99523,O15118,Q14168,Q14108,Q9BYW2,Q9BW83,Q9BWF3,Q06124,P30419,Q9Y679,P07602,P42858,P31751,O14976,O14964,Q8N4H5,Q9ULX6,Q06481,Q96D71,Q96PC5,Q15437,Q15904,Q9Y2T2,P07437,Q92572,P43307 67 +Protein heterotetramerization 0.549056791797816 0.8576647237825494 0.3910776243288489 1.0 0.8943554331908754 6 Q9Y285 1 +Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand 0.599783786153252 0.8565370981508154 0.3917007617896042 1.0 0.8944770458078661 5 P62136,P30154 2 +Body morphogenesis 0.5487437707975528 0.8562918103072169 0.3918363901065493 1.0 0.8944770458078661 6 O95470,Q12797,Q06124 3 +Hindbrain development 0.3675514461485665 0.8550607562621552 0.3925175136525221 1.0 0.8944770458078661 31 Q14103,Q5KU26,Q92542,Q02750,P54802,P04062,P46109,Q06124 8 +Protein catabolic process 0.3408080522720241 0.8539666426222038 0.3931234722458292 1.0 0.8945180041752836 246 Q15369,Q9H2J4,Q5VTR2,Q9Y3I1,O75477,O00231,P49721,Q8NHS3,O75503,Q14258,Q9UIQ6,Q9UPU5,Q9UJX2,O60502,P07858,Q8TEY7,P25788,Q8NF37,Q9Y5X3,P28072,P46379,Q92990,Q9UHG3,O75844,Q8N511,P49720,O43765,Q8TCT9,P10619,P50897,Q16850,P28074,Q92783,Q99436,P04062,Q96K76,Q96KB5,Q9NUJ1,Q9UJX3,Q13501,Q16740,Q9Y679,Q06787,O14773,O75832,P20618,Q9UJX4,Q9H000,O14964,Q8N3C0,Q9UJX6,P40818,P28070,Q9UL46,Q8IXJ6,Q07954,P60900,P42345,Q96RU2 59 +Calcium ion transport into cytosol 0.4379981349281873 0.853564448021632 0.3933463641445558 1.0 0.8945180041752836 14 P78417,P42858 2 +Stem cell proliferation 0.4577277014016097 0.8531614895289761 0.3935697561338869 1.0 0.8945180041752836 12 P04062 1 +Apoptotic cell clearance 0.4973705115812534 0.8526665345951034 0.3938442541968516 1.0 0.8945180041752836 9 P04083,Q8WTV0 2 +Chemical synaptic transmission postsynaptic 0.5094052592554784 0.8509365607798031 0.3948045940413709 1.0 0.8945180041752836 8 Q9UQB8 1 +Regulation of postsynaptic membrane potential 0.5094052592554784 0.8509365607798031 0.3948045940413709 1.0 0.8945180041752836 8 Q9UQB8 1 +Cellular response to lipid 0.3183603726761207 0.85088367660743 0.3948339732938541 1.0 0.8945180041752836 83 P30536,Q8TB36,P14174,P08670,P04083,Q9UBS8,Q16539,Q8WTV0,O43823,O15173,Q53EL6,Q8NI77,Q969T9,O15118,Q86X55,Q14103,Q92769,P40818,Q9H7B4 19 +Regulation of striated muscle cell differentiation 0.5093472168974291 0.8506568900031042 0.3949599772262022 1.0 0.8945180041752836 8 P67809,Q9BYT8,P42345 3 +Vascular associated smooth muscle cell proliferation 0.4817455508108023 0.8495517459833448 0.395574349404193 1.0 0.8952677932357335 10 Q53EL6,P09601 2 +Artery morphogenesis 0.5978631025884591 0.8487544169597562 0.3960179593089128 1.0 0.8956337645041329 5 Q96AY3,Q07954 2 +Chromatin disassembly 0.4565854283943575 0.846764756423006 0.3971262561750652 1.0 0.8965669415757899 12 Q969G3 1 +Epithelial to mesenchymal transition 0.3930805885487436 0.8460330658793215 0.3975342984371888 1.0 0.8965669415757899 22 Q9NQC3,Q92769,P17844,Q9UK61,Q92841,Q99729,Q06330,Q53EL6,P42345 9 +Positive regulation of cation channel activity 0.5082149904526224 0.8452030869872562 0.3979974590745243 1.0 0.8965669415757899 8 P78417,P42858 2 +Pyrimidine containing compound catabolic process 0.5458385906176797 0.84356091563058 0.3989148124662414 1.0 0.8965669415757899 6 Q9NRW3,Q9H773 2 +Negative regulation of viral process 0.407642733560268 0.8430404714175314 0.3992058095707604 1.0 0.8965669415757899 20 Q9NRW3,P52926,Q9UK61,Q12906,Q4G0J3,O94992,Q15047,P19474,Q14258 9 +Synaptic vesicle cytoskeletal transport 0.5964183704980531 0.8429062985755653 0.399280850629788 1.0 0.8965669415757899 5 Q92572 1 +Positive regulation of lipid biosynthetic process 0.4803948200970737 0.8425143838561939 0.3995000918420186 1.0 0.8965669415757899 10 P16435,P04083,Q8WTV0,P42345 4 +Negative regulation of keratinocyte proliferation 0.7710929156283525 0.8421159891338746 0.399723032245586 1.0 0.8965669415757899 3 O14936,P58107 2 +Hair follicle maturation 0.5452612695658119 0.8410334961946403 0.4003291695568056 1.0 0.8965669415757899 6 P18074,Q08J23 2 +Positive regulation of nervous system development 0.3623613298592165 0.8395993913728093 0.4011330406104885 1.0 0.8965669415757899 34 P30536,Q9UQB8 2 +Positive regulation of neurogenesis 0.3623613298592165 0.8395993913728093 0.4011330406104885 1.0 0.8965669415757899 34 P30536,Q9UQB8 2 +Cell junction maintenance 0.5182553369702836 0.8374013023187529 0.40236703396835 1.0 0.8965669415757899 7 Q8IUD2,Q96S97 2 +Axo dendritic protein transport 0.7694876807567215 0.8365052143077454 0.4028707445668154 1.0 0.8965669415757899 3 Q14168 1 +Protein localization to presynapse 0.7694876807567215 0.8365052143077454 0.4028707445668154 1.0 0.8965669415757899 3 Q14168 1 +Protein transport along microtubule 0.7694876807567215 0.8365052143077454 0.4028707445668154 1.0 0.8965669415757899 3 Q14168 1 +Regulation of phospholipase activity 0.4938919694140253 0.8352791926984475 0.4035605299309597 1.0 0.8965669415757899 9 P04083,P50897 2 +Cellular response to gonadotropin stimulus 0.7245551601423477 0.8347808934667239 0.4038410855024834 1.0 0.8965669415757899 2 P16435 1 +Cellular response to follicle stimulating hormone stimulus 0.7245551601423477 0.8347808934667239 0.4038410855024834 1.0 0.8965669415757899 2 P16435 1 +Response to follicle stimulating hormone 0.7245551601423477 0.8347808934667239 0.4038410855024834 1.0 0.8965669415757899 2 P16435 1 +Response to gonadotropin 0.7245551601423477 0.8347808934667239 0.4038410855024834 1.0 0.8965669415757899 2 P16435 1 +Protein localization to nuclear envelope 0.5059080577463488 0.8341011769749936 0.4042239719670937 1.0 0.896835654439343 8 Q8NFQ8 1 +Animal organ regeneration 0.4447485072922485 0.8335724491349777 0.4045219561917621 1.0 0.896835654439343 13 O14744,Q13243,P09601,P11717 4 +Muscle cell proliferation 0.3670901113472104 0.8335396726733826 0.4045404329091051 1.0 0.896835654439343 25 Q16539,Q9Y2S7,P52294,P09601,P10644,Q53EL6 6 +Chondrocyte proliferation 0.7241992882562254 0.8334051988506996 0.4046162436550546 1.0 0.896835654439343 2 Q14789 1 +Tissue remodeling 0.4313451110482319 0.8322087643405409 0.4052911176951017 1.0 0.897389871709944 15 O14773 1 +Collagen biosynthetic process 0.681537250815719 0.8300683618000906 0.4065001337453431 1.0 0.8979516467933141 4 Q92791,P08670 2 +Regulation of nervous system development 0.3329228771893883 0.8276921449794051 0.407844868773195 1.0 0.8987750179874653 59 P30536,Q9NQC3,Q92769,Q9UJX6,Q8N0X7,Q02750,Q06481,Q9UBS4,P55209,Q9UQB8,O75312,Q8IXJ6,Q96G23 13 +Regulation of rna binding 0.5160770314845928 0.8272970320241757 0.4080687256007791 1.0 0.8987750179874653 7 Q86X55 1 +Negative regulation of protein modification process 0.3160458842542095 0.8268721896416853 0.4083095077076477 1.0 0.8987750179874653 117 P30536,Q01105,Q9NVN8,Q96FW1,O75718,Q9Y3I1,Q13363,P29375,O95684,Q92990,P62942,P46109,Q53EL6,Q8WXW3,Q12972,Q15750,Q96S97,P04062,Q96ST3,Q96KB5,Q13501,P17931,Q32P28,Q92769,P30153,P04792,O94992,P19474,Q9H7B4,Q8IXJ6,Q07954 31 +Placenta development 0.3976991372952356 0.8246911049985878 0.4095469829580107 1.0 0.8987750179874653 21 Q16539,Q9BYW2,Q9H6E4,Q02750,P35613,P62993,P07858 7 +Neural retina development 0.5415051734915887 0.8246109137238846 0.4095925233067456 1.0 0.8987750179874653 6 P54802 1 +Arf protein signal transduction 0.6799835577343047 0.8243303125895665 0.4097518994294742 1.0 0.8987750179874653 4 Q15555 1 +Vesicle cargo loading 0.4429925254933387 0.8234662848911336 0.4102428823100255 1.0 0.8987750179874653 13 P55735,Q15437 2 +Ganglioside metabolic process 0.7654010983592598 0.8222540900896138 0.4109322998282225 1.0 0.8987750179874653 3 P06865 1 +Ganglioside catabolic process 0.7654010983592598 0.8222540900896138 0.4109322998282225 1.0 0.8987750179874653 3 P06865 1 +Intrinsic apoptotic signaling pathway in response to dna damage 0.3897852459301757 0.822009362300761 0.4110715684899584 1.0 0.8987750179874653 22 Q07820,P46379,P09601,P61978,Q96K76 5 +Regulation of mitotic cell cycle phase transition 0.3199233545473109 0.8200838716433902 0.4121682958801809 1.0 0.8987750179874653 80 Q9Y3I1,O60216,Q9UKG1,P04083,Q9UJX2,Q13564,P18074,Q13042,P31350,O43670,O75179,Q9NXR7,Q9Y619,Q96ST3,Q96K76,Q9UJX3,Q96DY7,Q7L7X3,Q9UJX4,Q06481,Q9UL46,Q8IXJ6 22 +Astrocyte differentiation 0.4603653165554891 0.8188667295995766 0.4128624538421097 1.0 0.8987750179874653 11 Q07954,Q02750,P15260,Q06124 4 +Dephosphorylation 0.3240898356371921 0.8179167100948379 0.413404748035854 1.0 0.8987750179874653 76 P62136,Q10713,O00743,Q969T7,Q9NPH0,Q92797,Q5H9R7,P62942,P30154,Q12972,P11117,Q15750,P04062,P17931,Q06124,P78318,Q9Y217,P42858,Q9H993,P30153,Q5TFE4,Q86XL3,P42345 23 +Regulation of neural precursor cell proliferation 0.4755899536767399 0.8175247986084558 0.4136285834544595 1.0 0.8987750179874653 10 Q06481 1 +Retina morphogenesis in camera type eye 0.7635591428683761 0.8158463933785386 0.4145879951510531 1.0 0.8993985074959566 3 P54802 1 +Eye photoreceptor cell development 0.7635591428683761 0.8158463933785386 0.4145879951510531 1.0 0.8993985074959566 3 P54802 1 +Response to oxygen levels 0.3314365440686043 0.814974145945654 0.4150871092973887 1.0 0.8993985074959566 56 Q92769,P42345,Q96A26,Q9Y487,P55786,O95831,P09601,Q15904,O75306,Q8IXJ6,Q6RW13,Q06330,Q8N511,P61421,P30519 15 +Regulation of nucleocytoplasmic transport 0.3524656188144462 0.8143869370276474 0.4154233196840233 1.0 0.8993985074959566 43 P50402,Q96ST2,Q9ULX6,Q08J23,O75312,Q9BYW2,Q9BWF3,Q07666,Q9NW64,Q06124 10 +Negative regulation of interleukin 12 production 0.7185053380783062 0.8114631463328984 0.4170997486613348 1.0 0.8993985074959566 2 Q8WXW3 1 +Histone phosphorylation 0.4200593574859475 0.810694844739007 0.4175409346047067 1.0 0.8993985074959566 17 O75844,Q9ULX6,O43823 3 +Negative regulation of leukocyte migration 0.6757863008673078 0.8088625216317695 0.4185942286722697 1.0 0.8996662238518276 4 P09601 1 +Negative regulation of dendritic spine development 0.7177935943060465 0.8087297427914052 0.4186706160863247 1.0 0.8996662238518276 2 Q92769 1 +Regulation of production of molecular mediator of immune response 0.3633743964218949 0.8040291113450431 0.4213801626064248 1.0 0.9017538718056314 25 Q01650,Q5RKV6,P14174,Q96FZ2,P09601,O96028,P04439 7 +Negative regulation of lipoprotein particle clearance 0.7601505346765925 0.8040153347434859 0.421388118829455 1.0 0.9017538718056314 3 Q92945 1 +Regulation of mrna binding 0.5366276819309415 0.8033428013150163 0.4217766255376189 1.0 0.9017538718056314 6 Q86X55 1 +Viral transcription 0.4294853992901931 0.8030102063231446 0.4219688354189084 1.0 0.9018605430184224 14 P19474,Q4G0J3,O94992 3 +Hindbrain morphogenesis 0.4726638720338429 0.8023427068283435 0.4223547447804385 1.0 0.9019267130068404 10 P04062 1 +Regulation of protein secretion 0.3566826596110433 0.8021179537662462 0.4224847304477463 1.0 0.9019267130068404 35 P53985,Q16850,Q06124 3 +Negative regulation of cytokine production involved in inflammatory response 0.7594565224534995 0.8016107829738849 0.422778138182053 1.0 0.9019267130068404 3 Q06481 1 +Innate immune response 0.3126374468476638 0.7994314379798106 0.4240402873065343 1.0 0.9019267130068404 114 Q9NRW3,P68371,P14174,P08670,Q9UKG1,P04083,O00743,P43243,P04439,Q16543,O00584,P01889,Q9NZ08,O43823,P10321,O60506,O75179,Q9NUD5,Q96ST3,Q9BYW2,P17931,Q06124,Q5KU26,Q06481,O94992,P19474,P07437,Q8IXJ6,Q96PK6 29 +Cell cycle g2 m phase transition 0.3528499946412096 0.7988213127208406 0.4243940305816562 1.0 0.9019267130068404 41 Q9ULX6,O43823,O60216,Q9Y619,Q9NXR7,P08183,Q96K76,Q07666,Q7L7X3 9 +Response to growth factor 0.3144590238249459 0.798808108713661 0.4244016880125425 1.0 0.9019267130068404 83 Q9UKG1,P04083,Q9UQB8,O75312,Q16539,P50402,O14737,P62942,Q06330,P46109,Q53EL6,Q8N0X7,Q99523,Q15750,Q9UNH7,Q9H223,Q92896,Q06124,Q92769,O14964,P40818,Q06481,P04792,Q8IXJ6,O14936 25 +Regulation of cell adhesion mediated by integrin 0.5853555855246794 0.7983091177364952 0.4246911282169821 1.0 0.9022017028196496 5 Q06124 1 +Myeloid cell development 0.447395845754261 0.7954722262162818 0.4263388606686611 1.0 0.9042410579489724 12 Q15904,Q06124 2 +Reactive oxygen species metabolic process 0.3552108189871747 0.7954280130631123 0.4263645701675129 1.0 0.9042410579489724 37 P30536 1 +Transmission of nerve impulse 0.534004975608625 0.7919352858824743 0.4283984109917718 1.0 0.9076058882823604 6 Q06787,Q12955,P04062 3 +U4 snrna 3 end processing 0.5080969545810613 0.790395269187005 0.429296964177845 1.0 0.9076058882823604 7 Q96B26 1 +Gamete generation 0.3046049924407058 0.7900020019523034 0.4295265991729207 1.0 0.9076058882823604 89 P16989,O75718,Q08J23,Q9P0K7,Q8N2A8,P46379,Q99417,Q14671,P46109,Q07666,Q8NI77,Q96PU8,P11717,Q15067,Q4G0J3,Q9BPZ3,Q9BW83,Q9BTX1,Q8NB78,P30153,Q8IXJ6,Q01085 22 +Leukocyte homeostasis 0.4965400536215967 0.7891746848578105 0.4300099157169104 1.0 0.908324278632687 8 P14174,P49327,P04083 3 +Inflammasome complex assembly 0.6700846711312988 0.7879324809780297 0.4307362008259492 1.0 0.9092522667002132 4 Q8IXJ6 1 +Positive regulation of translational initiation 0.4456539559737496 0.7857871417101528 0.431992200865682 1.0 0.9096063401673744 12 Q6PKG0,O15514,Q7Z739,Q07666,P42345 5 +Regulation of cell cell adhesion 0.3482926820809609 0.7855337417331529 0.4321406951782953 1.0 0.9096063401673744 44 Q16539,Q9Y624,Q96IZ0,Q92990,Q12955,P04083,P10644,Q96S97,Q06124,Q9NUQ9,P17931,P04439 12 +Protein localization to cytoplasmic stress granule 0.5318093040731037 0.7824014757134289 0.433978666819437 1.0 0.9118444335659058 6 P67809 1 +Negative regulation of lipid biosynthetic process 0.4831066692468961 0.7815959284679469 0.4344520804579286 1.0 0.9122124592110769 9 P49748,Q8WXW3,Q8NF37,O75477 4 +Negative regulation of protein containing complex assembly 0.3556195860719026 0.7804661188277087 0.4351165628197138 1.0 0.9124201385137412 34 P35080,P45880,Q96S97,P04062,Q9NUQ9 5 +Membrane raft organization 0.4944866766363995 0.7793640523635157 0.4357652931777491 1.0 0.9131761451281072 8 O15118,P50897 2 +Regulation of dna templated transcription in response to stress 0.4681416159941006 0.7789378410850057 0.4360163315306238 1.0 0.91340016294531 10 Q8IXJ6,Q96ST3,P09601 3 +Organ growth 0.4148084846362183 0.7773255393779055 0.4369667308283851 1.0 0.9140344178876192 17 O75844,P07602,Q06124 3 +Positive regulation of cilium assembly 0.5800885018334859 0.7772008428658022 0.4370402850243784 1.0 0.9140344178876192 5 Q15555 1 +Histone h4 deacetylation 0.5799661919300699 0.7767117099115137 0.4373288766008545 1.0 0.9143362227052508 5 Q8IXJ6,Q92769 2 +Retina development in camera type eye 0.424698909864648 0.7747322894310329 0.4384978669036901 1.0 0.9155037612465572 14 P54802,Q15555 2 +2 oxoglutarate metabolic process 0.4932978240540764 0.7736905211743906 0.4391138267484393 1.0 0.9155037612465572 8 P48735 1 +Regulation of histone h4 acetylation 0.5297447852959566 0.7734512310037784 0.4392553805141663 1.0 0.9155037612465572 6 O75844,Q96ST2 2 +Regulation of calcium ion transmembrane transporter activity 0.4177487650182892 0.7705699968764725 0.4409618507240851 1.0 0.9157793044279428 16 P78417,P62942,P42858 3 +Regulation of transmembrane transport 0.3270709206276302 0.7701787180643899 0.4411938862989131 1.0 0.9157793044279428 65 P42858,P31751,O43865,P78417,Q9BZF1,P21796,Q06481,P62942,P08183,O75844,Q9Y4C2,Q06124 12 +Lung epithelium development 0.5288959395489903 0.7697753297181256 0.4414331762670305 1.0 0.9157793044279428 6 Q02750,P09960 2 +Protein retention in er lumen 0.7074733096085399 0.7693423998234018 0.4416900729596764 1.0 0.9157793044279428 2 O43292 1 +Maintenance of protein localization in endoplasmic reticulum 0.7074733096085399 0.7693423998234018 0.4416900729596764 1.0 0.9157793044279428 2 O43292 1 +Regulation of leukocyte proliferation 0.403555393071064 0.7678775923957594 0.4425599109808986 1.0 0.9157793044279428 19 P02786,P14174,Q96IZ0,Q92990,P04083,P10644,P17931,P04439 8 +Regulation of oxidoreductase activity 0.4325984007212206 0.7639176505655165 0.4449163182836591 1.0 0.9158780221649934 13 P00374,Q8WTV0,P06280 3 +Regulation of response to osmotic stress 0.5767360146418858 0.7638114986465626 0.4449795834807357 1.0 0.9158780221649934 5 P16989 1 +Regulation of translational elongation 0.5766059629692468 0.7632928422013071 0.4452887698998178 1.0 0.9158780221649934 5 P49588,Q9H2P9 2 +Regulation of phosphoprotein phosphatase activity 0.4320193711185987 0.7606154805137011 0.4468867706468007 1.0 0.9158780221649934 13 P62942,P17931,P42345,P42858 4 +Second messenger mediated signaling 0.3955787023603072 0.759956933950968 0.4472803278038371 1.0 0.9158780221649934 20 O75844,P78417 2 +Lipid droplet organization 0.4786482190637064 0.7595188364032786 0.4475422505017485 1.0 0.9158780221649934 9 Q9Y679,Q8N0X7 2 +Selective autophagy 0.365762762565765 0.7591565829056833 0.4477588946207675 1.0 0.9158780221649934 24 O15270,Q9Y679,P21796,P42858 4 +Negative regulation of cellular response to growth factor stimulus 0.4784706590008943 0.7586411445636901 0.4480672529730576 1.0 0.9158780221649934 9 O14936,Q8N0X7 2 +Phosphatidylinositol dephosphorylation 0.6617394758927029 0.757480260470479 0.4487621875812824 1.0 0.9158780221649934 4 Q9Y217 1 +Positive regulation of chromatin organization 0.4780964982255495 0.7567920405495614 0.4491744621280547 1.0 0.9158780221649934 9 Q15047,Q9UK61,Q9Y6X9,Q96ST3 4 +Negative regulation of cysteine type endopeptidase activity 0.4070069405188639 0.7566704638176186 0.4492473143589381 1.0 0.9158780221649934 18 Q15392 1 +Regulation of chromosome segregation 0.3507974428390256 0.7556762631201479 0.4498433191150637 1.0 0.9158780221649934 37 Q9UJX4,O60566,P49454,Q00839,O60216,Q13042,Q9Y6A5,Q14671,Q8IXJ6,Q99661,Q9UJX3,Q9H1A4,Q9UJX2,O43670 14 +Oocyte differentiation 0.4894151784665926 0.7551966108419553 0.450131021902451 1.0 0.9158780221649934 8 Q8N2A8,P30153 2 +Multi multicellular organism process 0.3572800148952663 0.7544361458992229 0.4505873740511696 1.0 0.9158780221649934 26 Q9UIQ6,Q9BQE5,P07858 3 +Regulation of cell communication by electrical coupling 0.7032028469750911 0.7531862928014635 0.4513379750696891 1.0 0.9158780221649934 2 Q12955 1 +Negative regulation of transcription regulatory region dna binding 0.7032028469750895 0.7531862928014591 0.4513379750696917 1.0 0.9158780221649934 2 Q96ST3 1 +Neuron differentiation 0.3337981782322638 0.7524262476069419 0.4517947669553228 1.0 0.9158780221649934 183 P30536,Q9NQC3,Q8NHS3,O75503,Q9UQB8,Q96G23,O00264,P50897,Q15555,Q8N0X7,Q8WUJ1,P54802,Q14108,P42892,P04062,O60443,Q86X55,Q9BW83,Q06124,Q32P28,Q7L7X3,O14976,Q06481,P00374,Q9BVA1 25 +B cell activation 0.3534909757969841 0.7516946643827467 0.4522346998305135 1.0 0.9158780221649934 33 P78318,Q5RKV6,Q96FV9,P14174,Q96FZ2,Q96IZ0,Q12888,P17812,O96028,Q9UQ84,Q06330,P13051 12 +Nephron development 0.4478586175053916 0.7513049402374407 0.4524691567449577 1.0 0.9158780221649934 11 P57740,Q9BW27 2 +Regulation of lymphocyte apoptotic process 0.5729425614996339 0.7487067038806322 0.4540340021686204 1.0 0.9164807377722612 5 P14174,P17931 2 +Positive regulation of interferon gamma production 0.5727261038222003 0.7478463238429263 0.454552856908377 1.0 0.9170650920816252 5 Q9NUQ9,P04439 2 +Regulation of cell development 0.3153843607462748 0.7466632565224858 0.4552668544575322 1.0 0.9178224934930406 79 P30536,Q9NQC3,Q92769,Q8IXJ6,Q9UJX6,Q8N0X7,Q02750,Q06481,Q9UBS4,P55209,Q9UQB8,Q96S97,P46109,Q9Y624,Q96G23 15 +Regulation of transcription elongation from rna polymerase ii promoter 0.4169954983935081 0.7454810468669822 0.4559809646984945 1.0 0.9184102569002645 15 Q8WX92,P35269,Q4G0J3,O94992,Q8IXH7,Q9NYV4,O14776 7 +Fluid transport 0.7007117437722599 0.7438024489079216 0.456995998410266 1.0 0.9188906326381816 2 O43865 1 +Protein modification by small protein removal 0.3438290189297392 0.7425967341781948 0.4577258663480241 1.0 0.9188906326381816 44 P34897,Q96FW1,Q8TEY7,Q96RU2,P40818,Q99496,Q9NXR7,Q99627,Q92905,P19474,Q9H9Q2,Q9BT78,Q9H8M7,Q96K76,Q9UPU5,Q9UNS2,Q93009,Q7L5N1 18 +Glycine metabolic process 0.4975974361088516 0.7421563511953299 0.4579926110269223 1.0 0.9188906326381816 7 P23378,P00374 2 +Nuclear transcribed mrna catabolic process exonucleolytic 3 5 0.4750651628400246 0.7418315861502953 0.4581893805486068 1.0 0.9188906326381816 9 Q6PGP7,Q96B26 2 +Immune response 0.3353228291207072 0.7412059399632759 0.4585685823864085 1.0 0.9188906326381816 199 Q9NRW3,Q96FW1,Q9NQC3,Q5RKV6,P68371,P14174,P08670,Q9UKG1,P04083,O96028,O00743,P43243,Q6P179,Q14258,P04439,Q16543,P55899,Q01650,O00584,Q9Y487,Q96FZ2,P01889,Q96FV9,Q9NZ08,P46379,O43823,P62942,Q14671,Q9NPR9,P46109,Q07666,P10321,O60506,O75179,P45985,Q9NUD5,P09601,Q96ST3,Q9BYW2,Q9NUQ9,P17931,Q06124,Q9H000,Q96IZ0,Q5KU26,Q06481,P28070,O94992,P19474,Q9UQ84,P07437,Q8IXJ6,Q07954,O43657,Q96PK6,P42345,P13051 57 +Negative regulation of protein secretion 0.4607084179133217 0.7406408254232817 0.4589112474051093 1.0 0.9188906326381816 10 Q16850,Q16836,Q06124 3 +Response to dexamethasone 0.474746521688433 0.7402611683105859 0.4591415383104644 1.0 0.9188906326381816 9 P16435,P40818,Q9H7B4,P04062 4 +Positive regulation of fat cell differentiation 0.5220263789470261 0.7401189680376975 0.4592278102517155 1.0 0.9188906326381816 6 Q16539,Q96A49,Q86X55 3 +Wound healing 0.3324062184889146 0.7354473784219935 0.4620670764281664 1.0 0.9221083972030586 51 Q8WTV0,P42785,P09601,Q13310,Q9Y624,O14936 6 +Cellular lipid metabolic process 0.3317244251995426 0.7349425434169526 0.4623744870795425 1.0 0.9221083972030586 178 P07099,O75874,P14174,Q14914,P29375,P42126,P04066,P48449,P04083,O15254,Q96N66,P06865,Q15800,Q9BY49,Q96G23,Q8N4Q0,P16278,P61916,Q9HB40,Q8WTV0,Q8NF37,Q9BZF1,P06280,Q9NPH0,P51648,Q709F0,Q9BWD1,O75844,P37268,Q8NHP8,Q8WXW3,P50897,Q96PU8,Q15067,O15270,Q8NCC3,P04062,P35790,Q06124,P07602,Q9Y217,P31751,Q16836,Q07954,Q06481,Q06136,Q99943,Q8NBX0,P42356,P23786,Q9H7Z7,P17900 52 +Intracellular sterol transport 0.5205663213596665 0.7338379579218642 0.4630475033664489 1.0 0.9221083972030586 6 O15118 1 +Rhythmic behavior 0.6551357725870497 0.7335484480986472 0.463223989977561 1.0 0.9221083972030586 4 P54802 1 +Positive regulation of calcium ion transport into cytosol 0.5201428729087493 0.7320178478745718 0.4641576741836488 1.0 0.9221083972030586 6 P78417 1 +Positive regulation of release of sequestered calcium ion into cytosol 0.5201428729087493 0.7320178478745718 0.4641576741836488 1.0 0.9221083972030586 6 P78417 1 +Somatic diversification of immune receptors 0.3541774252309828 0.7314163992537852 0.4645248514621767 1.0 0.9222098946478112 25 Q5RKV6,P52701,Q96FZ2,Q96FV9,Q12888,O96028,Q9UQ84,Q8WYA6,P13051 9 +Cytoplasmic pattern recognition receptor signaling pathway 0.4172202437319775 0.7307990606993687 0.4649018973760626 1.0 0.922553962813958 14 Q9NUD5,O75179,O43657,Q14671 4 +Histone arginine methylation 0.7386970452118263 0.7304176910327651 0.4651349078729045 1.0 0.922553962813958 3 Q99873,Q86X55 2 +Meiotic chromosome segregation 0.3910093514356209 0.7287270962299116 0.4661686145668087 1.0 0.9234481120693552 20 Q9BTX1,P30153,P61160,P46379,O60216,Q92791 6 +Actin myosin filament sliding 0.7376290494838101 0.7267962043651434 0.4673508086053812 1.0 0.9247601142717248 3 P60660,P14649 2 +Skeletal muscle organ development 0.3691636237964751 0.7264864315522963 0.4675406224847918 1.0 0.9247601142717248 23 Q16539,P50402,P16989,P17844,P60660,P14649,Q13131,P51114,Q9BYT8 9 +Response to vitamin d 0.5672612105457593 0.7261807753054655 0.4677279558043894 1.0 0.9247601142717248 5 Q8TB36 1 +Cellular response to peptide hormone stimulus 0.3253533946244051 0.7259905528579774 0.4678445620240603 1.0 0.9247601142717248 54 Q7L576,P31751,O43865,Q9Y5X3,Q9BZF1,Q06481,Q96A49,Q9UKG1,P43490,P16435,Q9HCD5,Q9UQB8,Q13243,P62993,Q6RW13,Q92572,Q06124 17 +Response to ether 0.7369170523317911 0.7243842716822994 0.4688298531554524 1.0 0.9264031117699104 3 Q14103,Q6PKG0 2 +Dna dealkylation 0.4827964818160641 0.7238036537647667 0.4691862858827214 1.0 0.9266975778703166 8 P29372,Q9NRW3,Q9C0B1,Q8N3C0 4 +Pyrimidine nucleoside triphosphate metabolic process 0.4713738132369373 0.7236651275206065 0.4692713472283172 1.0 0.9266975778703166 9 Q9H773 1 +Regulation of low density lipoprotein particle clearance 0.5660899408763136 0.7215518297403763 0.4705700640388164 1.0 0.9283943013119488 5 Q92945 1 +Tissue migration 0.3328196572971169 0.7207716751101791 0.4710500052609341 1.0 0.9287628759609644 50 Q9NQC3,Q8WTV0,Q15555,Q4VCS5,P35080,P42785,P09601,P04083,Q13685,Q06124 10 +Regulation of dna damage response signal transduction by p53 class mediator 0.4564040904030488 0.7185742981198806 0.4724032541942244 1.0 0.9302732821096334 10 O75844,P14174 2 +Negative regulation of mrna processing 0.3753495806880179 0.7175751112907149 0.4730193082815521 1.0 0.930550560623206 22 P98175,P38159,Q13242,P61978,P22626 5 +Regulation of short term neuronal synaptic plasticity 0.6925266903914573 0.7131902149631548 0.4757280604161149 1.0 0.933918438307596 2 Q96A49 1 +Negative regulation of b cell activation 0.7333679897502661 0.7123906050347101 0.4762229316371866 1.0 0.934600408109276 3 Q96IZ0 1 +Biomineralization 0.4548857585911084 0.7108113993390623 0.4772011157221381 1.0 0.9349578495127612 10 O75844 1 +Small rna loading onto risc 0.6486981046875339 0.7103704103627222 0.4774744673018727 1.0 0.9349578495127612 4 Q5KU26 1 +Regulation of skeletal muscle cell differentiation 0.732645069419717 0.7099535835925707 0.4777329204232792 1.0 0.9349578495127612 3 Q9BYT8,P17844 2 +Peptidyl lysine dimethylation 0.6484136475224123 0.709349884981632 0.4781073789046752 1.0 0.9351895925276869 4 Q03164 1 +Bone development 0.3741210333184193 0.7087596297824196 0.4784736538617058 1.0 0.9351895925276869 22 Q32P28,Q15904,O96028,O75844,Q06124 5 +Negative regulation of proteasomal ubiquitin dependent protein catabolic process 0.4133736690503617 0.7083357360646715 0.4787367899889247 1.0 0.9351895925276869 14 P46379 1 +Response to toxic substance 0.3401583677623289 0.7074452531990811 0.4792898231778635 1.0 0.9356930405046584 44 P07099,Q15165,P78417,P21266,P08183 5 +B cell apoptotic process 0.7309068597854225 0.7041024116113519 0.481368998390058 1.0 0.938631097579469 3 P14174 1 +Cardiac muscle cell proliferation 0.6467729903044657 0.7034699903633228 0.4817629022362828 1.0 0.938631097579469 4 Q16539,P10644 2 +Dicarboxylic acid transport 0.4216483488906197 0.7017859727012986 0.482812647943478 1.0 0.9388085804614924 13 Q9H2D1 1 +Respiratory chain complex iv assembly 0.5126405378821043 0.6998892921285732 0.4839964450616292 1.0 0.9391329298821542 6 O43819,O75880,Q9Y2R0,Q15070 4 +Regulation of protein export from nucleus 0.4211112140592455 0.6987567091916962 0.4847040871058208 1.0 0.9391329298821542 13 P50402,Q9Y3B8,Q9NW64,Q06124 4 +Positive regulation of cell cycle g1 s phase transition 0.4059669411321254 0.6982364831442897 0.4850293140790751 1.0 0.9391329298821542 16 P04083,Q96DY7,O75179 3 +Glycosphingolipid biosynthetic process 0.6882562277580063 0.6973590053780403 0.4855781499311256 1.0 0.9391329298821542 2 Q13131 1 +Peptidyl glutamic acid modification 0.6449691208234787 0.6970174515184938 0.4857918724030319 1.0 0.9391329298821542 4 Q14679 1 +Regulation of heterotypic cell cell adhesion 0.644427245426071 0.6950816814413743 0.4870041140995691 1.0 0.940329183439419 4 Q14254,Q96S97 2 +Positive regulation of cellular response to insulin stimulus 0.5115122655886625 0.6950778263502173 0.4870065299113417 1.0 0.940329183439419 6 Q9BZF1,Q06124 2 +Negative regulation of glycoprotein metabolic process 0.7280170879316629 0.6944017353424379 0.4874303057571241 1.0 0.940860751624397 3 Q9NY61,Q9Y287 2 +Metal ion transport 0.2960300950877921 0.6930512391975465 0.4882773964014446 1.0 0.9414685502427924 90 P30536,Q9HD20,P78417,P21796,O15173,O75844 6 +Positive regulation of immune response 0.3177033257250918 0.6914935738657221 0.4892554177018642 1.0 0.9414685502427924 71 Q5RKV6,Q9UKG1,P04083,O96028,P43243,P04439,Q96FZ2,P01889,P46379,P46109,Q07666,Q9NUD5,Q96ST3,Q9NUQ9,P17931,Q96IZ0,Q06481,O94992,Q96PK6 19 +Negative regulation of rna splicing 0.3968579978225391 0.6911406890967642 0.489477132203731 1.0 0.9414685502427924 18 P61978,P98175,P22626,P38159 4 +Microtubule anchoring 0.4755618101605686 0.6897027198591962 0.4903811550954786 1.0 0.9414685502427924 8 O95684 1 +C4 dicarboxylate transport 0.5098893682731362 0.6881668446780307 0.4913477202186094 1.0 0.9423942200439854 6 Q9UBX3 1 +O glycan processing 0.642307755144548 0.6875215906157996 0.4917540999162857 1.0 0.9425225122562546 4 Q86SF2,O43505 2 +Signal transduction in absence of ligand 0.4357895424186723 0.6867894125347268 0.4922154425736802 1.0 0.9425225122562546 11 P62136,P30153,Q07820,P30154 4 +Regulation of cell projection assembly 0.3415297583109922 0.6866565839536791 0.4922991622341 1.0 0.9425225122562546 40 Q7L576,Q06787,Q15555,P11233,P42858,P51116,Q66K14,Q9Y277,P35080,P07737,P51114,P42345 12 +Positive regulation of transmembrane transport 0.3446297090530297 0.6849164070714738 0.4933966720242158 1.0 0.942870047200896 34 P42858,P31751,P78417,Q9BZF1,Q9UKG1,P08183,Q9Y4C2,Q06124 8 +Cardiac chamber development 0.4000575857000744 0.6844932184549577 0.4936637701984749 1.0 0.942870047200896 17 Q15750,P62942,O96028,P43243,O75844 5 +Positive regulation of glycoprotein metabolic process 0.5565519503710468 0.6840617561932948 0.4939361700016218 1.0 0.942870047200896 5 Q96IZ0 1 +Positive regulation of plasma membrane bounded cell projection assembly 0.3844311400384594 0.6840480625688424 0.4939448166644293 1.0 0.942870047200896 20 Q06787,Q7L576,Q15555,P11233,P42858,P07737,P42345 7 +Production of molecular mediator involved in inflammatory response 0.4088189724548327 0.6818676159425824 0.4953226642580834 1.0 0.9434504729195896 14 Q16539,Q8IV08,Q06481,Q9UKG1,Q9UNH7,O60684,Q53EL6 7 +Fc receptor signaling pathway 0.5552395982790512 0.6789334156549508 0.4971800518230893 1.0 0.9452835248733624 5 Q06481,P45985 2 +Regulation of vesicle fusion 0.6397965418214027 0.6785883184421091 0.497398746511668 1.0 0.9454156738585604 4 P31751 1 +Ephrin receptor signaling pathway 0.7230331078675957 0.6777521218572282 0.497928872632829 1.0 0.9455724500671976 3 Q06330,Q06124 2 +Golgi to lysosome transport 0.554837081998604 0.6773620049481934 0.4981762990708716 1.0 0.9457588997040484 5 O14976 1 +Pyrimidine nucleotide catabolic process 0.7226730059706518 0.6765532272757074 0.4986894637918622 1.0 0.9461662072003084 3 Q9H773 1 +Regulation of extrinsic apoptotic signaling pathway 0.3471985031705745 0.6737637890810152 0.5004614998078023 1.0 0.9482130528227656 27 Q07820,P42858,P62136,P30153,Q14247,P09601,P17931,P30154 8 +Cellular lipid catabolic process 0.3185389849359661 0.6731154443761661 0.5008738490584221 1.0 0.9482130528227656 56 Q8NHP8,P50897,Q8WTV0,O75874,P31751,P42126,P06280,Q8NCC3,P06865,Q9BWD1,P04062,P17900 12 +Arachidonic acid metabolic process 0.5537031223800558 0.6729389464041491 0.5009861334911672 1.0 0.9482130528227656 5 P07099 1 +Locomotor rhythm 0.7215707670833559 0.6728869928215959 0.5010191878482835 1.0 0.9482130528227656 3 P54802 1 +Cell adhesion molecule production 0.6814946619217128 0.6725013308301486 0.5012645931759814 1.0 0.9482130528227656 2 Q5KU26 1 +Positive regulation of cell adhesion molecule production 0.6814946619217128 0.6725013308301486 0.5012645931759814 1.0 0.9482130528227656 2 Q5KU26 1 +Regulation of toll like receptor 3 signaling pathway 0.6814946619217083 0.6725013308301312 0.5012645931759925 1.0 0.9482130528227656 2 Q14254 1 +Positive regulation of long term synaptic potentiation 0.6807829181494721 0.669900107703474 0.5029214710910039 1.0 0.9493015421856054 2 Q13501 1 +Protein polyubiquitination 0.3350498779680447 0.6695566760315268 0.5031404397828303 1.0 0.9493015421856054 45 Q9UJX4,Q96FW1,P52888,Q5VTR2,Q9H000,Q9UJX6,P55786,Q13042,P19474,Q9UIQ6,Q9UJX3,Q9UJX2,Q9UBS8 13 +Endocytosis 0.2982044347971924 0.6693964772079433 0.5032425982180477 1.0 0.9493015421856054 104 Q13432,Q9UKG1,Q8TEY7,Q8WTV0,O15260,P50897,Q5VW38,P11717,Q99523,O15118,P61978,Q14108,Q9H223,Q06787,Q9Y217,O14976,Q06481,Q96D71,Q08380,Q07954,Q9Y2T2 21 +Aminoglycan biosynthetic process 0.48147398672539 0.6689295522942829 0.5035404176984446 1.0 0.9493015421856054 7 O43505 1 +Endothelial cell migration 0.344637769074176 0.6684247462966991 0.5038625035947732 1.0 0.9493015421856054 32 Q8WTV0,P09601,P42785,P04083,Q13685 5 +Regulation of t cell activation 0.3453426562425554 0.6683810605149544 0.5038903819367824 1.0 0.9493015421856054 31 Q96IZ0,Q92990,P04083,Q06124,Q9NUQ9,P17931,P04439 7 +Regulation of fc gamma receptor signaling pathway involved in phagocytosis 0.7186944511632726 0.6633448243544546 0.5071097347175446 1.0 0.9511788035364628 3 Q06481 1 +Fc gamma receptor signaling pathway 0.7186944511632726 0.6633448243544546 0.5071097347175446 1.0 0.9511788035364628 3 Q06481 1 +Positive regulation of chromosome segregation 0.4801766012131678 0.6630893143171126 0.5072733539376002 1.0 0.9511788035364628 7 Q8IXJ6 1 +Histone h3 k4 demethylation 0.7177556825751301 0.6602383775311184 0.5091008679343458 1.0 0.9511788035364628 3 Q8NB78 1 +Abscission 0.7177204019329149 0.660121708322524 0.5091757288890826 1.0 0.9511788035364628 3 Q8N0X7 1 +Atrioventricular canal development 0.7177021641541352 0.6600614001771545 0.5092144279522677 1.0 0.9511788035364628 3 Q06124 1 +Regulation of extrinsic apoptotic signaling pathway in absence of ligand 0.4441032906064497 0.6560316002892157 0.511803792208358 1.0 0.9511788035364628 10 P62136,Q07820,P30154 3 +Nucleotide excision repair dna incision 0.6323042188765742 0.6520969465621949 0.5143386337355127 1.0 0.9511788035364628 4 P19447,P18074 2 +Regulation of phosphatidylcholine metabolic process 0.632210943088488 0.65176871663375 0.5145503855283944 1.0 0.9511788035364628 4 Q8WTV0 1 +Regulation of histone h3 k14 acetylation 0.7150930087059879 0.6514489864096747 0.5147566974461943 1.0 0.9511788035364628 3 Q03164 1 +Positive regulation of dna demethylation 0.6750889679715293 0.6491997629033961 0.5162092649427705 1.0 0.9519829638389028 2 Q93009 1 +Dna damage response signal transduction by p53 class mediator 0.412238538078353 0.6490034488529047 0.5163361469876495 1.0 0.9519829638389028 13 O75844,P14174 2 +Hippo signaling 0.6313624865438984 0.6487848936057747 0.5164774230200644 1.0 0.9519829638389028 4 Q01085,Q4VCS5 2 +Regulation of fatty acid biosynthetic process 0.4768265930207507 0.6480488775819546 0.5169533375577806 1.0 0.9525831055840812 7 P04083,Q8WXW3,O75477 3 +Negative regulation of intracellular signal transduction 0.2943699660381348 0.6467255881480196 0.5178095593121614 1.0 0.9537394515971612 89 Q99829,P30086,P16989,P14174,Q10713,P45880,Q96FV9,Q53EL6,O95881,Q96S97,P04062,Q96KB5,Q96K76,Q9NUQ9,P78318,O75832,Q07820,Q9H000,P30153,P04792,O43657,P42345 22 +Leukocyte proliferation 0.3420113584184729 0.6464095005757741 0.5180141892471792 1.0 0.9537394515971612 32 P14174,Q92542,Q96IZ0,Q92990,P17812,P04083,P04062,P17931,P04439 9 +Response to peptide hormone 0.3110191387473873 0.6444299706890312 0.519296655033151 1.0 0.9544033941256028 75 Q9UKG1,P04083,Q9UQB8,P62993,P09960,Q16539,Q9Y5X3,Q9BZF1,P43490,Q6RW13,O43865,Q99523,P16435,Q9HCD5,Q06124,Q7L576,Q16836,P31751,Q06481,P35613,Q13243,Q92572,P42345,Q96A49 24 +Positive regulation of vesicle fusion 0.7126031392934521 0.6432593570012564 0.5200558237553592 1.0 0.954967764456016 3 P31751 1 +Cell cell junction maintenance 0.7123982360718436 0.6425866745117584 0.5204923319151189 1.0 0.955215727583582 3 Q96S97 1 +Negative regulation of extrinsic apoptotic signaling pathway 0.3844910708735108 0.6417482791922988 0.5210366364118106 1.0 0.9559378010832784 19 Q07820,P42858,Q14247,P09601,P17931 5 +Glyoxylate metabolic process 0.7117527019019025 0.6404687176198751 0.5218679202764089 1.0 0.9563554108709088 3 P48735 1 +Regulation of lipoprotein particle clearance 0.4985260157788832 0.6401226239328622 0.522092881687565 1.0 0.9564910642538592 6 Q92945 1 +Positive regulation of cellular protein catabolic process 0.3326672851311538 0.6362372201270168 0.5246218169928785 1.0 0.9576312198867788 44 O43765,Q06787,O75832,Q9H000,P46379,P04062 6 +Nucleotide transport 0.4531890758066876 0.6351295947043168 0.5253438967961679 1.0 0.9576312198867788 9 Q9H2D1 1 +Smooth muscle cell apoptotic process 0.4735022917494699 0.6331827999518309 0.5266142764745636 1.0 0.9576312198867788 7 P98175,P45985 2 +Endothelial cell chemotaxis 0.70916242872983 0.6319899973447741 0.527393413387397 1.0 0.9576312198867788 3 P04792 1 +Positive regulation of leukocyte proliferation 0.4252911185036622 0.6313554831560317 0.5278081165779542 1.0 0.9576312198867788 11 P14174,P04439 2 +Positive regulation of ubiquitin dependent protein catabolic process 0.3488288532731002 0.6308956489735903 0.5281087569741567 1.0 0.9576312198867788 24 O43765,O75832,Q9H000,P04062,Q8IXJ6 5 +Mitochondrial cytochrome c oxidase assembly 0.5428027665396534 0.6307287328087089 0.5282179086368779 1.0 0.9576312198867788 5 Q9Y2R0,Q15070 2 +Rig i signaling pathway 0.4251421200619534 0.6305739950436132 0.5283191067307476 1.0 0.9576312198867788 11 O75179,Q9NUD5,Q8ND56,Q14671,Q14258 5 +Branched chain amino acid transport 0.6697508896797297 0.6299757797074845 0.528710430865043 1.0 0.9576312198867788 2 Q01650 1 +Tryptophan transport 0.6697508896797297 0.6299757797074845 0.528710430865043 1.0 0.9576312198867788 2 Q01650 1 +Leucine import across plasma membrane 0.6697508896797297 0.6299757797074845 0.528710430865043 1.0 0.9576312198867788 2 Q01650 1 +Leucine transport 0.6697508896797297 0.6299757797074845 0.528710430865043 1.0 0.9576312198867788 2 Q01650 1 +Pseudouridine synthesis 0.4960259809583511 0.629639572034815 0.5289304267480728 1.0 0.9576312198867788 6 Q8WWH5,Q96PZ0,Q9UJK0 3 +Positive regulation of tyrosine phosphorylation of stat protein 0.7081537204489013 0.6286968747785865 0.5295475245270336 1.0 0.9576312198867788 3 Q8WXW3 1 +Negative regulation of transport 0.3124297628764407 0.6285929362656116 0.5296155859748415 1.0 0.9576312198867788 71 Q06787,Q16850,Q16836,Q13432,P31751,P78417,P21796,Q12955,P09601,Q9UKG1,P04083,Q06481,P62942,Q86U90,Q8N183,Q06124 16 +Maintenance of location in cell 0.3367795126108109 0.6285681016756005 0.5296318489222127 1.0 0.9576312198867788 36 P30536,P10253,P78417,P42858 4 +Negative regulation of wound healing 0.6253928133136585 0.62788605487113 0.5300785869201623 1.0 0.9576312198867788 4 O14936 1 +External encapsulating structure organization 0.386926715208851 0.6278166809022352 0.5301240373231106 1.0 0.9576312198867788 18 Q92791,Q07954,P13674,O75718 4 +Membrane protein proteolysis 0.4245270193554788 0.6273494878561512 0.5304301707140617 1.0 0.9576312198867788 11 Q8TCT9,Q9NZ08,Q16740,P38159 4 +Cell adhesion mediated by integrin 0.4952566406047995 0.6264203386354843 0.5310392726457707 1.0 0.9576312198867788 6 Q06124 1 +Negative regulation of ubiquitin dependent protein catabolic process 0.3821006377707014 0.6261558662286272 0.5312127118579497 1.0 0.9576312198867788 19 Q9H2J4,P46379 2 +Negative regulation of protein catabolic process 0.3364660566710527 0.6258290415170781 0.5314270809686001 1.0 0.9576312198867788 36 Q9H2J4,P10619,Q16850,P46379 4 +Memory 0.4948842184327414 0.6248631292058754 0.5320608932442381 1.0 0.9576312198867788 6 Q9BPZ3 1 +Regulation of amyloid beta clearance 0.4716078500396437 0.6247383388245501 0.5321428061082771 1.0 0.9576312198867788 7 Q16850,P15260 2 +Regulation of muscle cell differentiation 0.3903731986776565 0.6244576689962459 0.5323270621464866 1.0 0.9576312198867788 17 P67809,O75179,P42345,Q9BWF3,Q53EL6,Q9BYT8 6 +Inflammatory cell apoptotic process 0.6240827831396899 0.6233227103769601 0.5330724767666131 1.0 0.9576312198867788 4 O75844 1 +Negative regulation of ion transmembrane transporter activity 0.4374008617999101 0.6223245843595017 0.5337284588734605 1.0 0.9576312198867788 10 P78417,Q06787,P62942 3 +Mononuclear cell migration 0.3813697027934277 0.6213996469162348 0.5343367043144749 1.0 0.9576312198867788 19 P04083,P46109,Q9Y624,P04062 4 +Regulation of fatty acid transport 0.6234575616306031 0.6211477916208638 0.534502386734975 1.0 0.9576312198867788 4 P31751 1 +Phospholipid metabolic process 0.3144434908972412 0.62020765329881 0.5351210834683457 1.0 0.9584687128148408 61 Q8NHP8,Q8WTV0,Q8NF37,O75874,Q9Y217,Q9BZF1,O15270,Q9NPH0,Q96N66,Q8NCC3,Q99943,P42356,P35790 13 +Response to peptide 0.2967902745246768 0.6180212615488561 0.5365613234463626 1.0 0.9589799481496126 86 P08670,Q9UKG1,P04083,Q9UQB8,P62993,P09960,Q16539,Q9Y5X3,Q9BZF1,P43490,Q6RW13,O43865,Q99523,P16435,Q9UNH7,Q9HCD5,Q06124,Q7L576,Q16836,P31751,Q06481,P35613,Q13243,Q07954,Q92572,P42345,Q96A49 27 +Vesicle uncoating 0.6225071225071076 0.6178452683525825 0.536677340039289 1.0 0.9589799481496126 4 O14976,Q9UN37,Q99961 3 +Neuromuscular process controlling balance 0.449570949350713 0.6177333255239973 0.5367511405108449 1.0 0.9589799481496126 9 O14773,P17900 2 +Negative regulation of leukocyte cell cell adhesion 0.3975264330417773 0.6169387877960759 0.5372751014819219 1.0 0.9589799481496126 14 Q96IZ0,Q92990,P04083,P10644,P17931 5 +Positive regulation of catabolic process 0.3093519776379334 0.6163476250268682 0.5376651127413448 1.0 0.9592296788969318 133 Q9H074,Q96B26,Q9Y3I1,P21796,Q9UBS8,Q9C0B1,P11940,Q969T7,Q8NF37,P46379,Q13131,Q92945,Q96HY6,Q14671,Q86VM9,Q9UII2,O43765,O60506,Q00839,O15270,Q13190,P09601,O15514,Q7Z739,Q9Y2L1,P04062,Q9HCE1,Q8IYB8,Q14103,P67809,Q06787,O75832,P42858,Q6PKG0,P31751,Q9H000,Q07954,Q9UJX6,P19474,Q8IXJ6,P53634,Q16531,Q96C86 43 +Positive regulation of attachment of spindle microtubules to kinetochore 0.6216759580855085 0.614960887914008 0.5385805505055452 1.0 0.9595664570070612 4 Q8IXJ6 1 +Negative regulation of peptidyl tyrosine phosphorylation 0.4594777123171182 0.6148340651182155 0.5386643100390411 1.0 0.9595664570070612 8 Q8WXW3,O95684,P30153 3 +Protein dna complex disassembly 0.4060559258327107 0.6146855268490429 0.5387624197618943 1.0 0.9595664570070612 13 Q969G3 1 +Regulation of gene silencing by rna 0.3885988455089683 0.6135514528478502 0.5395117723314511 1.0 0.9598576750586802 17 Q06787,Q02750,Q14671,O75844,P51114 5 +Platelet activation 0.4218393449896613 0.6132920149796999 0.5396832722477636 1.0 0.9598576750586802 11 Q16539,Q9Y624,P04792 3 +Negative regulation of cell cycle phase transition 0.3133892571612433 0.611888815716633 0.5406113218518631 1.0 0.960879728586626 58 Q16539,Q7L7X3,Q13564,Q96RU2,Q96FV9,Q9Y3I1,O60216,Q12888,Q9Y619,Q9NXR7,Q08J23,Q8N6R0,Q06124,Q96K76 14 +Proteasome assembly 0.5377568778343604 0.611390270122025 0.540941242519503 1.0 0.960879728586626 5 O00231,O75832 2 +Cholesterol efflux 0.4584020933351344 0.6098799256603494 0.5419413512469 1.0 0.960879728586626 8 Q07954,O15118,Q8WTV0 3 +Positive regulation of immune system process 0.292839498615646 0.6090533874455899 0.5424890525000361 1.0 0.960879728586626 102 Q5RKV6,P14174,Q9UKG1,P04083,O96028,P04439,Q01650,Q96FZ2,P01889,P46379,P46109,Q07666,O75179,Q9NUD5,P09601,Q96ST3,Q9NUQ9,P17931,Q06124,Q96IZ0,Q06481,Q96PK6 22 +Regulation of cell projection organization 0.2922344073769109 0.6089158307525617 0.5425802305023111 1.0 0.960879728586626 101 Q9NQC3,P51116,P08670,Q9UQB8,P07737,Q96G23,P11233,P51114,P46109,Q15555,Q8N0X7,Q14108,Q86X55,Q32P28,Q06787,P42858,Q92769,O14976,Q9UJX6,Q66K14,Q02750,P35080,P42345 23 +Negative regulation of transporter activity 0.4209866681653869 0.6088433443245265 0.5426282804389122 1.0 0.960879728586626 11 P78417,Q06787,P62942 3 +Negative regulation of leukocyte proliferation 0.4910219532097955 0.6087592821117155 0.5426840064086373 1.0 0.960879728586626 6 Q96IZ0,P10644,Q92990 3 +Negative regulation of t cell proliferation 0.4910219532097955 0.6087592821117155 0.5426840064086373 1.0 0.960879728586626 6 Q96IZ0,P10644,Q92990 3 +Regulation of calcium mediated signaling 0.536473808931814 0.6064945092053102 0.5441864273713879 1.0 0.9626186990514604 5 P42858 1 +Cell cell adhesion via plasma membrane adhesion molecules 0.4339864999435567 0.6052673811509018 0.5450013511216194 1.0 0.9633578893560572 10 Q16539,Q14126,P35613,Q96S97 4 +Response to oxidative stress 0.2984311969311672 0.6039665989581273 0.545865848955557 1.0 0.9633578893560572 84 Q07820,P28074,Q15165,O75874,Q9NR28,Q15392,P09601,O75306,P00374,P04062,P30519,O43169 12 +Insulin processing 0.6615658362989463 0.6008606396862209 0.5479328110019039 1.0 0.9633578893560572 2 Q969M3 1 +Vasculogenesis 0.4564197406198442 0.6007684929882079 0.5479941920685203 1.0 0.9633578893560572 8 Q9BYW2,Q4VCS5,Q92990,Q96PU8 4 +Response to lipid 0.3041145658506435 0.6006171992362482 0.5480949797381744 1.0 0.9633578893560572 124 P30536,Q99829,Q8TB36,O75874,P14174,P08670,Q13126,P04083,Q9NXN4,Q14258,Q9UBS8,P16278,Q16539,Q8WTV0,O43823,O15173,Q53EL6,Q8NI77,P11717,Q969T9,O15118,P23378,P04062,Q86X55,Q14103,Q92769,P40818,P35573,O95983,Q9H7B4 30 +Regulation of synapse structure or activity 0.3378175961679452 0.5994223301276713 0.5488912898327833 1.0 0.9633578893560572 28 P50897,Q9UQB8,P07437 3 +Positive regulation of intracellular signal transduction 0.2999736963299004 0.5991383904174034 0.5490806029024533 1.0 0.9633578893560572 116 Q99829,P55735,Q9NQC3,Q8TB61,P14174,Q9UMX5,Q9BZF1,P62942,Q14671,P46109,Q53EL6,O15344,O75179,Q99873,Q15555,Q9NUD5,P09601,Q15750,O60443,Q7L7X3,Q06124,Q07820,Q02750,O94992,P19474,Q9Y624,Q01085,O43657 28 +Gene silencing by rna 0.3330277483667189 0.5977803229251604 0.5499865218171023 1.0 0.9633578893560572 37 Q06787,P11940,Q5KU26,Q02750,O94992,Q9BWF3,Q14671,O75844,P51114,Q8IWR0,P22626 11 +Negative regulation of cell adhesion 0.3360324606685123 0.5966393220171176 0.5507482120634004 1.0 0.9633578893560572 32 Q96IZ0,Q92990,P04083,Q96S97,O14936,P17931,Q06124 7 +Production of molecular mediator of immune response 0.3343014772519494 0.5964108605007462 0.5509007869188993 1.0 0.9633578893560572 34 Q01650,Q5RKV6,P14174,Q96FV9,Q96FZ2,P13051,P09601,O96028,Q9UQ84,Q8WYA6,P04439 11 +Regulation of translational fidelity 0.4025446843096907 0.5953386838825093 0.5516171028600856 1.0 0.9633578893560572 13 Q5JTZ9,Q86U90 2 +Glial cell development 0.3855664203273263 0.594985770644447 0.5518529825408667 1.0 0.9633578893560572 17 P15260,P31751,Q92542,P08670,Q8IXJ6,Q07954 6 +Positive regulation of phagocytosis 0.4646309507447747 0.593820338819164 0.552632284097107 1.0 0.9633578893560572 7 Q06481 1 +Chaperone mediated protein folding 0.3322142867163844 0.5934405044132544 0.5528863885688549 1.0 0.9633578893560572 38 Q32P28,Q9H2J4,O75718,O14976,O14737,P62942 6 +Cellular response to peptide 0.3117622566686707 0.5923913163344696 0.5535885798624887 1.0 0.9633578893560572 64 P08670,Q9UKG1,Q9UQB8,P62993,Q9Y5X3,Q9BZF1,P43490,Q6RW13,O43865,P16435,Q9HCD5,Q9UNH7,Q06124,Q7L576,P31751,Q06481,Q13243,Q07954,Q92572,Q96A49 20 +Proton transporting two sector atpase complex assembly 0.6149924902900356 0.5918958895753614 0.5539203064666429 1.0 0.9633578893560572 4 Q8N511 1 +Microtubule anchoring at microtubule organizing center 0.6962845246057054 0.5903279193776082 0.5549708249690657 1.0 0.9633578893560572 3 Q8TD16 1 +Positive regulation of protein serine threonine kinase activity 0.357354682572719 0.5899464235790054 0.555226569121618 1.0 0.9633578893560572 22 P14174,Q15750,O75832,Q7L7X3 4 +Protein destabilization 0.4308671077648455 0.5897558295767209 0.5553543595947177 1.0 0.9633578893560572 10 P19474 1 +Endothelial cell proliferation 0.3905463329106192 0.5892390173505295 0.5557009468630707 1.0 0.9633578893560572 15 Q8WTV0,P09601 2 +Positive regulation of protein polymerization 0.3427971604940293 0.5859910887981683 0.5578815032310627 1.0 0.9633578893560572 24 P36404,Q14247,P35080,P07737,Q9UQB8,P62993,P42345 7 +Protein localization to organelle 0.3154757018033653 0.5855044364457178 0.5582085844228462 1.0 0.9633578893560572 290 P30536,P55735,Q9NVN8,Q9NQC3,Q9NS69,Q8TB36,Q99567,Q99595,Q9UK61,Q9Y3I1,O60830,Q8TD16,P55786,Q10713,O60216,Q9UKG1,O14925,Q9UFC0,P40855,O75312,Q9Y6X3,Q5JRX3,P57740,Q9NW64,Q16539,O00505,Q14789,Q9Y512,P11233,Q92973,O00629,P52294,Q9BZF1,P46379,O14737,Q15629,P31483,Q8NFQ8,O60684,O43765,O15344,Q8WXW3,Q9BW27,Q15555,Q92783,Q4G0J3,Q9UHB9,Q99523,O15027,Q14108,Q96ST3,Q9BYW2,Q96DY7,Q13501,P67809,P30419,Q9Y679,O14773,O14976,O14964,Q8N4H5,Q9Y6C9,Q06481,Q9Y2T2 64 +Cardiac ventricle development 0.3916963173710402 0.5838592178227129 0.5593150330271577 1.0 0.9633578893560572 14 O75844,O96028,P62942,P43243 4 +Regulation of focal adhesion disassembly 0.6942278134610964 0.583753333478187 0.5593862792049269 1.0 0.9633578893560572 3 Q15555 1 +Regulation of glycogen metabolic process 0.694133709929925 0.5834530592802694 0.5595883480284218 1.0 0.9633578893560572 3 P31751 1 +Regulation of glucan biosynthetic process 0.694133709929925 0.5834530592802694 0.5595883480284218 1.0 0.9633578893560572 3 P31751 1 +Male gamete generation 0.3104924726437039 0.5824673394821298 0.560251934689606 1.0 0.9633578893560572 66 Q8NI77,Q9P0K7,Q8N2A8,Q96PU8,O75718,P16989,P11717,Q15067,Q4G0J3,P46379,Q99417,Q9BW83,Q08J23,Q14671,Q9BPZ3,P46109,Q07666 17 +Positive regulation of dna methylation dependent heterochromatin assembly 0.4845975136560765 0.5821644271945886 0.560455931841894 1.0 0.9633578893560572 6 Q15047,Q9UK61 2 +Cellular protein catabolic process 0.3264354157310893 0.5819195610698085 0.5606208639356121 1.0 0.9633578893560572 211 Q15369,Q9H2J4,Q5VTR2,Q9Y3I1,O75477,O00231,P49721,Q8NHS3,Q14258,Q9UPU5,Q9UJX2,P07858,Q8TEY7,P25788,Q9Y5X3,P28072,P46379,Q92990,Q9UHG3,O75844,Q8N511,P49720,O43765,Q8TCT9,P50897,P28074,Q92783,Q99436,P04062,Q96K76,Q96KB5,Q9UJX3,Q13501,Q16740,Q9Y679,Q06787,O14773,O75832,P20618,Q9UJX4,Q9H000,Q8N3C0,P40818,P28070,Q9UL46,Q8IXJ6,Q07954,P60900,Q96RU2 49 +Midbrain development 0.3831842576028398 0.5804691348968177 0.561598295089802 1.0 0.9633578893560572 17 P00367,P35222,P11413,Q8IXJ6,O75489,P63167,P60953,O15027,P27348,P09543,P24539,P62258,P80723,Q04917,O14949,Q9Y5K5 16 +Negative regulation of macroautophagy 0.4154535589574644 0.5801123206569504 0.5618388757188595 1.0 0.9633578893560572 11 P09601 1 +T cell activation 0.3219289955417565 0.5799339601216277 0.5619591532949746 1.0 0.9633578893560572 48 P42345,Q92542,Q96IZ0,Q92990,P17812,P04083,P62942,Q06124,P04062,Q9NUQ9,P17931,P04439 12 +Mapk cascade 0.3040696131209821 0.5795510717437048 0.5622173964122283 1.0 0.9633578893560572 77 P30086,P14174,P62993,Q16539,Q9UMX5,P46109,Q53EL6,O15344,P29372,Q99873,P45985,P49327,Q15750,P04062,O60443,Q96KB5,Q7L7X3,Q06124,P78318,O75832,P30153,Q02750 22 +Positive regulation of intracellular protein transport 0.3244359028619361 0.5791985858596955 0.5624551849124084 1.0 0.9633578893560572 46 Q15154,Q16539,P50402,P30419,Q9Y3B8,Q9Y282,P31751,Q9Y2F5,P55786,Q99496,Q12955,O14737,O75312,Q9Y4C2,Q9NW64 15 +Maintenance of location 0.3101491719935249 0.5766086611266631 0.5642038470047313 1.0 0.9633578893560572 58 P30536,Q9Y679,Q8WTV0,P42858,P78417,Q9BZF1,P10253,P62942,P04062,P17900 10 +Regulation of execution phase of apoptosis 0.4831918323539854 0.5763789734905074 0.5643590534859619 1.0 0.9633578893560572 6 Q8IXJ6,P63167 2 +Heart morphogenesis 0.3485509056772461 0.5761777618980805 0.564495034778403 1.0 0.9633578893560572 23 Q9NQC3,P10253,O96028,P62942,Q15750,O75844,P46109,Q53EL6,P42345 9 +Interleukin 6 production 0.4143684269263596 0.5745066578534358 0.5656249964947988 1.0 0.9633578893560572 11 Q06124,P04062 2 +Negative regulation of cyclin dependent protein serine threonine kinase activity 0.5277914545749249 0.5736087794075005 0.5662325694087276 1.0 0.9633578893560572 5 O94992 1 +Negative regulation of platelet derived growth factor receptor signaling pathway 0.6910089074393642 0.5735094341572851 0.5662998132060999 1.0 0.9633578893560572 3 O14964 1 +Regulation of platelet derived growth factor receptor signaling pathway 0.6910089074393642 0.5735094341572851 0.5662998132060999 1.0 0.9633578893560572 3 O14964 1 +Synaptic signaling 0.305192628137272 0.5733845905004363 0.5663843215368449 1.0 0.9633578893560572 75 Q06787,P50897,Q13432,Q92542,Q9UJX6,P52294,O14936,P35080,Q8IUD2,Q14168,O95721,Q9UQB8,Q13501,Q9BVA1,Q9BPZ3,P46109,Q7L0J3 17 +Transcription elongation from rna polymerase ii promoter 0.3339687958007029 0.5717430151029599 0.5674960881646349 1.0 0.9633578893560572 26 Q8WX92,P35269,O14776,Q4G0J3,O94992,Q8IXH7,Q9NYV4,Q9BYW2,Q6IA86,Q16186 10 +Hepatocyte growth factor receptor signaling pathway 0.527119140934198 0.5710806439059338 0.5679449786791109 1.0 0.9633578893560572 5 Q8IXJ6 1 +Lymphocyte activation involved in immune response 0.3338503456677735 0.5708327010725317 0.5681130538111274 1.0 0.9633578893560572 26 Q5RKV6,P17931,Q96FV9,Q96FZ2,Q12888,P04083,O96028,Q9UQ84,P42345,P13051 10 +Protein exit from endoplasmic reticulum 0.3673876665404028 0.5702094182468506 0.5685356689324808 1.0 0.9633578893560572 20 Q8TCT9,P55735,Q9Y679,O15260 4 +Attachment of gpi anchor to protein 0.6085648404127406 0.5699385685010682 0.5687193646518838 1.0 0.9633578893560572 4 Q96S52,O43292 2 +Prostanoid metabolic process 0.3978634703406237 0.5697200859135225 0.5688675645811287 1.0 0.9633578893560572 13 P14174,Q14914,P04083,Q8N4Q0,Q9H7Z7 5 +Negative regulation of supramolecular fiber organization 0.3234156969772064 0.569458806249745 0.5690448186142982 1.0 0.9633578893560572 46 O15344,P29372,Q7L7X3,Q07157,Q9Y624,Q9UJX6,P35080,O15212,Q15691,P07737,Q96S97,Q9NUQ9,P61758,Q9NQP4 14 +Dendritic cell differentiation 0.6079820853012383 0.5679591743399413 0.5700626897360612 1.0 0.9633578893560572 4 P01889,P17931 2 +Regulation of proteasomal ubiquitin dependent protein catabolic process 0.3277268618903232 0.5670575892269318 0.5706750557670262 1.0 0.9633578893560572 41 O43765,O75832,Q9H000,Q8IXJ6,Q92990,P46379,P04062,Q96KB5 8 +Myeloid leukocyte cytokine production 0.4584630336315184 0.5667419868304011 0.570889490226667 1.0 0.9633578893560572 7 P09601 1 +Dna replication checkpoint signaling 0.607602167512668 0.5666697770333478 0.5709385582025099 1.0 0.9633578893560572 4 Q9Y619 1 +Mitotic dna replication checkpoint signaling 0.607602167512668 0.5666697770333478 0.5709385582025099 1.0 0.9633578893560572 4 Q9Y619 1 +Non motile cilium assembly 0.4126108950661344 0.5654485039537815 0.5717687412630559 1.0 0.9633578893560572 11 O00471,Q15691,Q8WXW3,Q15555 4 +Negative regulation of peptidyl threonine phosphorylation 0.6512455516014327 0.5648146560500071 0.5721998372663886 1.0 0.9633578893560572 2 Q8IXJ6 1 +Regulation of neuron differentiation 0.386304129227024 0.5647623324406141 0.5722354307763684 1.0 0.9633578893560572 15 Q99829,Q8WUJ1 2 +Apoptotic mitochondrial changes 0.3330899397200874 0.5622111437532327 0.5739721697691351 1.0 0.9633578893560572 28 Q96A26,P45880,O14737,P30419 4 +Skeletal system morphogenesis 0.3801064088675536 0.5618061727526746 0.5742480859805197 1.0 0.9633578893560572 17 Q16539,O95470,Q9BYW2,O75844,Q92896 5 +Negative regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway 0.6056822554216452 0.560166435311851 0.57536591886448 1.0 0.9633578893560572 4 O43657 1 +Embryonic digit morphogenesis 0.5241575800930811 0.5599769014488779 0.5754951931271195 1.0 0.9633578893560572 5 P42892 1 +Sequestering of calcium ion 0.3828463402768329 0.5595273339482585 0.5758018818912745 1.0 0.9633578893560572 16 P78417,P42858 2 +Neurogenesis 0.3252101431269023 0.5592165329428735 0.576013951172166 1.0 0.9633578893560572 231 P30536,Q99829,Q9NQC3,P15260,Q9Y3I1,P08670,P04083,Q8NHS3,O75503,Q9UQB8,Q96N66,O75312,Q96G23,O00264,Q15022,Q8TEY7,P18074,Q14247,Q9H9T3,Q06330,P46109,O14949,P50897,Q15555,Q99873,Q92542,Q969G3,Q8N0X7,Q12955,Q8WUJ1,P54802,Q14108,P42892,P04062,O60443,Q86X55,Q96ST3,Q9BW83,Q06124,Q32P28,Q7L7X3,Q06787,Q92769,P31751,O14976,Q9UJX6,Q8IXJ6,Q02750,Q06481,P35613,O75306,Q9UBS4,P55209,P00374,Q9BVA1,Q07954,P42345 57 +Endoplasmic reticulum tubular network organization 0.4470130941703137 0.55788900276091 0.5769201814906482 1.0 0.9633578893560572 8 O95197 1 +Muscle cell development 0.3316097494434452 0.5569633948712042 0.5775524393643354 1.0 0.9638925410496832 25 Q00839,P12814,O43707,P10644,Q9H7B4,O75844,P42345 7 +Cellular response to light stimulus 0.3312895290929717 0.5545379033549599 0.5792107730209841 1.0 0.964287971577768 25 P30419,Q06787,Q15555,P31751,Q96K76,Q96RU2 6 +Detoxification of nitrogen compound 0.6039207852519395 0.5542185318064741 0.5794292970965578 1.0 0.964287971577768 4 P21266 1 +Negative regulation of neural precursor cell proliferation 0.5226022715543824 0.5541673729902886 0.5794643051652864 1.0 0.964287971577768 5 Q06481 1 +Positive regulation of anion transmembrane transport 0.6028911889357111 0.5507503421305961 0.5818048293597389 1.0 0.9651563360347292 4 Q9Y4C2 1 +Cellular response to hormone stimulus 0.2926407815136695 0.5484482012819738 0.5833841871574308 1.0 0.966006165146757 109 P31751,O43865,Q9BZF1,Q06481,P42785,O43823,P43490,O15118,O15173,P04083,Q9UQB8,Q86X55,Q92572,Q06124,P07858 15 +Endothelium development 0.3577458472363679 0.5477304023266287 0.5838770333852721 1.0 0.966317252693254 21 Q07157,P21266,O60869,Q96S97,Q9Y624,Q06330 6 +Interferon gamma production 0.4445051556863356 0.5465625987135005 0.5846792703013579 1.0 0.9666049962354122 8 Q9NUQ9,P04439 2 +Toll like receptor 3 signaling pathway 0.6817372730509025 0.5443270039122541 0.5862164675784991 1.0 0.9674098320429554 3 Q5KU26,Q14254 2 +Positive regulation of actin nucleation 0.6444839857651291 0.5416266268371173 0.5880757450253162 1.0 0.9685336545546236 2 Q7L576 1 +Positive regulation of arp2 3 complex mediated actin nucleation 0.6444839857651291 0.5416266268371173 0.5880757450253162 1.0 0.9685336545546236 2 Q7L576 1 +Lipid catabolic process 0.3070609520669093 0.5412723125529401 0.5883199014750409 1.0 0.9685336545546236 65 Q8NHP8,Q8N2A8,P50897,Q8WTV0,O75874,P31751,P42126,P06280,Q8NCC3,P06865,Q9BWD1,P04062,P17900 13 +Negative regulation of amyloid precursor protein catabolic process 0.4525269100174802 0.5409266946780625 0.5885581103856476 1.0 0.9685336545546236 7 O95197 1 +Regulation of organic acid transport 0.4206271270552263 0.5393635053393915 0.5896360574790456 1.0 0.9690154813912634 10 Q7L0J3,P31751 2 +Positive regulation of alpha beta t cell activation 0.4517362574397349 0.5375074579504645 0.5909171347326361 1.0 0.9706173879732284 7 P04439 1 +Regulation of action potential 0.44217515663293 0.5360823425630886 0.5919016429725299 1.0 0.9712275275807668 8 Q06787,P04062 2 +Bile acid and bile salt transport 0.6427046263345171 0.5355835136775365 0.5922464253054178 1.0 0.9715273307711207 2 Q13131 1 +Substantia nigra development 0.3827734095782544 0.5339073496076634 0.5934056369025744 1.0 0.9715273307711207 14 P00367,P11413,P63167,O75489,P60953,O15027,P27348,P09543,P24539,Q8IXJ6,P80723,Q04917,P62258 13 +Cell killing 0.3718744594418259 0.5337617612028888 0.5935063728262318 1.0 0.9715273307711207 18 Q9NUQ9,P01889,P07437,P04439 4 +Response to caffeine 0.6778212887148518 0.5321516053120837 0.5946209979737218 1.0 0.9715273307711207 3 Q13131,Q92769 2 +Muscle cell apoptotic process 0.3908300127360378 0.5316363394018706 0.5949778910170711 1.0 0.9715273307711207 13 P98175,P45985,P09601 3 +Response to corticosteroid 0.3282217278848424 0.5313869028503128 0.5951506955216641 1.0 0.9715273307711207 25 Q99829,P16278,P40818,O95831,P35573,P16435,P04083,Q9H7B4,P04062 9 +Regulation of phosphatase activity 0.3803387752165398 0.5306795327172571 0.5956408715403172 1.0 0.9715273307711207 15 P62942,P17931,P42345,P42858 4 +I kappab phosphorylation 0.6772782777178324 0.5304705687728918 0.595785709475058 1.0 0.9715273307711207 3 Q8IUD2 1 +Protein monoubiquitination 0.3548214338830507 0.5281449315716389 0.5973987472283153 1.0 0.9715273307711207 21 Q5VTR2,Q99496,P19474,Q14258,Q16531 5 +Mitotic nuclear membrane organization 0.5154365775959376 0.527602824297502 0.597775032338433 1.0 0.9715273307711207 5 Q8IXJ6,Q86XL3 2 +Negative regulation of receptor binding 0.6402135231316803 0.5271655490620465 0.5980786303292625 1.0 0.9715273307711207 2 P10586 1 +Positive regulation of heart rate 0.6402135231316696 0.5271655490620103 0.5980786303292875 1.0 0.9715273307711207 2 P09493 1 +Calcium ion regulated exocytosis of neurotransmitter 0.6402135231316697 0.5271655490620103 0.5980786303292875 1.0 0.9715273307711207 2 Q15042 1 +Neurotrophin trk receptor signaling pathway 0.5957899975076947 0.5270038318463314 0.5981909275080177 1.0 0.9715273307711207 4 Q99523,Q06124 2 +Regulation of production of small rna involved in gene silencing by rna 0.470633473290961 0.5252716905760029 0.5993943342144967 1.0 0.9719452138989932 6 O75844 1 +Adaptive thermogenesis 0.3344436485220691 0.5246638863205955 0.5998168665292676 1.0 0.9723815510862032 24 Q9UIQ6,Q06481,Q16836 3 +Cellular response to chemical stress 0.3040107711037105 0.5239867027493222 0.600287788548683 1.0 0.9727079418771976 70 P30536,Q07820,Q92769,P16989,Q9NR28,Q96IZ0,Q9Y3I1,P04792,P09601,P04083,O43813,P00374,P04062,Q96ST3,Q8IXJ6 15 +Cell death in response to oxidative stress 0.3475978667945678 0.5223878028754801 0.6014003466205713 1.0 0.9727079418771976 22 Q07820,Q9NR28,Q96IZ0,Q9Y3I1,P04792,P04062 6 +Negative regulation of protein dephosphorylation 0.4170611277352402 0.5220209220997435 0.601655763460951 1.0 0.9727079418771976 10 P62942,Q12972 2 +Peptidyl tyrosine dephosphorylation 0.4292097719457541 0.5215212803728674 0.6020036851399424 1.0 0.9727079418771976 9 Q9Y217,Q06124 2 +Mismatch repair 0.4169421490134122 0.521444251486922 0.6020573316814621 1.0 0.9727079418771976 10 Q9UQ84 1 +Response to retinoic acid 0.4289766263026723 0.5204382097731587 0.6027581842496668 1.0 0.9727079418771976 9 Q9NXN4,Q8TB36,Q92769,P11717 4 +Phosphatidylcholine biosynthetic process 0.4477591109561341 0.5203795159667819 0.6027990842537576 1.0 0.9727079418771976 7 P35790 1 +Regulation of microtubule depolymerization 0.428959611204437 0.5203591847695471 0.6028132520714509 1.0 0.9727079418771976 9 O15344,Q9UJX6,Q7L7X3 3 +Positive regulation of cell development 0.3095551206215907 0.5191671209441181 0.6036442049823147 1.0 0.9728619854966756 52 P30536,Q92769,Q9UJX6,Q02750,P55209,Q96S97,Q9UQB8,Q8IXJ6,Q9Y624,P46109 10 +Peptidyl lysine hydroxylation 0.4689581400381617 0.5185375295390194 0.6040832824288103 1.0 0.9728652879533054 6 Q92791 1 +Positive regulation of erk1 and erk2 cascade 0.3960528013646935 0.5177884676989789 0.6046058653788344 1.0 0.9731743380507172 12 P14174,Q02750,Q06124 3 +Establishment of endothelial intestinal barrier 0.4683344987779294 0.5160360648401998 0.6058292206626206 1.0 0.9744476242825376 6 Q9Y624,Q07157 2 +Dna double strand break processing 0.6724813100747604 0.5156988080227225 0.6060647872795011 1.0 0.9744476242825376 3 P49959,Q9H4L7 2 +Positive regulation of cell activation 0.3231580270413723 0.5141547198975056 0.6071438224855235 1.0 0.9747920944414528 38 Q96FZ2,P14174,O96028,Q9NUQ9,Q06124,P04439 6 +Negative regulation of nuclear division 0.3747870650623441 0.5124941715975275 0.6083051983803394 1.0 0.9747920944414528 16 O43670,Q96DY7,O60566,O60216 4 +Attachment of spindle microtubules to kinetochore 0.3643477161217365 0.5123875670248657 0.6083797906763366 1.0 0.9747920944414528 19 Q96R06,Q8NBT2,Q96DB5,Q8IXJ6,Q99661,Q9HBM1,O43670 7 +Neural precursor cell proliferation 0.3460821070768138 0.5120185766130381 0.6086380084490772 1.0 0.9749593173765932 22 O75306,Q06481 2 +Epithelial cell differentiation 0.2874102795842919 0.5113331845565239 0.6091177720811003 1.0 0.975234795775122 87 Q9Y3B8,Q16822,P08670,P21796,O60869,P04083,P09960,P07858,Q07157,P18074,P21266,Q06330,Q15417,P49327,P20073,Q96S97,P17931,O14773,P07602,Q92769,P31751,Q02750,P31942,P07437,Q9Y624 25 +Oocyte maturation 0.5903496525540044 0.5090243283857576 0.6107351714621592 1.0 0.9760980533557888 4 P30153 1 +Protein demethylation 0.4664965727521903 0.5086810723442742 0.6109757916614158 1.0 0.9762364074025194 6 Q8NB78 1 +Lens development in camera type eye 0.6698557366034754 0.5076744694172266 0.6116816558099638 1.0 0.976363170301087 3 P08670 1 +Metaphase anaphase transition of cell cycle 0.3249077466208965 0.506561579022686 0.6124624722831458 1.0 0.9768876634428124 25 Q9UJX4,O60566,P49454,O60216,Q9Y6A5,Q13042,Q9UJX3,Q9H1A4,Q9UJX2,O43670 10 +Histone h2a ubiquitination 0.4347913646254946 0.5031556901586214 0.61485481504043 1.0 0.9771539427873402 8 Q16531,Q96FW1,Q99496 3 +Cell cycle phase transition 0.3020142985181771 0.5028914693413642 0.6150405791176987 1.0 0.9771539427873402 134 Q07864,Q9Y3I1,O60216,Q9UKG1,P04083,O00743,Q08J23,O75312,Q8N6R0,Q9H1A4,Q9UJX2,Q16539,Q13564,O60566,Q96FV9,P18074,Q12888,O43823,Q96HY6,Q9Y6A5,Q13042,Q9UN37,Q07666,O43670,P31350,O75179,P61289,Q9NXR7,Q9Y619,P08183,Q96ST3,Q96K76,Q9UJX3,Q96DY7,Q06124,O43633,Q7L7X3,Q9UJX4,Q9ULX6,Q06481,Q9UL46,Q8IXJ6,P49321,Q16531,Q96RU2 45 +Cation transport 0.3045656030233259 0.5026654463109146 0.6151995073062175 1.0 0.9771539427873402 140 P30536,Q9HD20,P42858,P78417,Q70HW3,P21796,O43772,Q9Y619,Q96ES6,O15173,P36543,O75844,O75964,O14936 14 +Glycerolipid metabolic process 0.3078027055397493 0.5014376070675295 0.616063178318516 1.0 0.9771539427873402 52 Q8WTV0,Q8NF37,Q9Y217,Q9BZF1,Q9NPH0,Q8NCC3,Q99943,P42356,P35790,Q06124 10 +Lymphocyte homeostasis 0.5080214297077787 0.5004808564329198 0.616736532410177 1.0 0.9771539427873402 5 P14174 1 +Regulation of homotypic cell cell adhesion 0.6666995226438756 0.4980867019698111 0.6184229330317736 1.0 0.9771539427873402 3 Q9Y624 1 +Cellular response to mechanical stimulus 0.433626281281543 0.4980017118421905 0.6184828356213123 1.0 0.9771539427873402 8 P49327,Q9Y624,P45985 3 +Regulation of insulin receptor signaling pathway 0.3921570897078427 0.4976200288227763 0.6187518840198165 1.0 0.9771539427873402 12 Q9Y5X3,Q9BZF1,Q06124 3 +T cell migration 0.4636923391683717 0.4975091144780948 0.618830077137098 1.0 0.9771539427873402 6 Q9Y624 1 +Regulation of g protein coupled receptor signaling pathway 0.3991274736729776 0.4968976211452524 0.6192612491417699 1.0 0.9771539427873402 11 P30419 1 +Trabecula morphogenesis 0.6661345611267789 0.4963773077567281 0.619628232152095 1.0 0.9771539427873402 3 P62942 1 +Heart trabecula morphogenesis 0.6661345611267789 0.4963773077567281 0.619628232152095 1.0 0.9771539427873402 3 P62942 1 +Negative regulation of proteolysis involved in cellular protein catabolic process 0.3499684834020845 0.495925107862086 0.6199472509272319 1.0 0.9771539427873402 21 Q9H2J4,P46379 2 +Positive regulation of hexokinase activity 0.6306049822064035 0.4951747182142246 0.6204767949879977 1.0 0.9771539427873402 2 P49792 1 +Regulation of hexokinase activity 0.6306049822064035 0.4951747182142246 0.6204767949879977 1.0 0.9771539427873402 2 P49792 1 +Intestinal epithelial cell differentiation 0.630604982206402 0.4951747182142212 0.6204767949880001 1.0 0.9771539427873402 2 P04818 1 +Intestinal epithelial cell development 0.630604982206402 0.4951747182142212 0.6204767949880001 1.0 0.9771539427873402 2 P04818 1 +Chromatin remodeling at centromere 0.6302491103202923 0.4940048828263984 0.621302731073847 1.0 0.9780117090257544 2 P49321 1 +Regulation of post translational protein modification 0.6653286123127556 0.4939423789225213 0.6213468739999506 1.0 0.9780117090257544 3 Q32P28 1 +Aromatic amino acid transport 0.6645419866141284 0.4915699486395142 0.6230233919888906 1.0 0.9793496032703638 3 Q01650 1 +Amyloid fibril formation 0.4314517596000915 0.4884139032193518 0.6252566959430812 1.0 0.9793496032703638 8 P61758,O15212,P62942,Q9NQP4 4 +Negative regulation of smooth muscle cell proliferation 0.4402241857140346 0.4882736954085595 0.6253559908716966 1.0 0.9793496032703638 7 P09601 1 +Positive regulation of t cell proliferation 0.4305785061440593 0.4845753804054968 0.6279775811448018 1.0 0.9803265661449272 8 P04439 1 +Negative regulation of mitotic cell cycle phase transition 0.3193822126787846 0.484195147566993 0.6282473803232536 1.0 0.9803265661449272 39 P52926,Q9Y3I1,O60216,P78527,Q13564,O60566,P49959,Q9UN37,Q96JB5,O43670,P49454,P24941,P15927,Q9Y619,Q9NXR7,Q6IQ49,Q96K76,Q7L7X3,Q15645,Q7Z7L1,O96017 21 +Centriole assembly 0.4391258910890565 0.4836334603014515 0.628646023745409 1.0 0.9803265661449272 7 Q96PK6 1 +Response to transforming growth factor beta 0.3229596141019471 0.4833449968287604 0.6288507955466514 1.0 0.9803265661449272 29 Q06481,Q9UKG1,O14737,Q15750,P62942,P46109,Q92896 7 +Microtubule anchoring at centrosome 0.626334519572957 0.4812096519249287 0.6303675016919885 1.0 0.9805773380862556 2 Q15154 1 +Regulation of guanyl nucleotide exchange factor activity 0.5809852768489987 0.4785352451898756 0.6322692948509607 1.0 0.9805773380862556 4 Q9Y2S7 1 +Mucopolysaccharide metabolic process 0.4288486557292566 0.476991884927404 0.6333679002832759 1.0 0.9805773380862556 8 O43505 1 +Dna integrity checkpoint signaling 0.3190974034291572 0.4767585009280336 0.6335340997765875 1.0 0.9805773380862556 35 Q16539,Q7L7X3,Q13564,Q96RU2,Q96FV9,Q9NXR7,Q9Y619,Q06124 8 +Positive regulation of nlrp3 inflammasome complex assembly 0.6249110320284774 0.4765904138979683 0.6336538108668368 1.0 0.9805773380862556 2 Q9H6R0 1 +Chemokine c c motif ligand 5 production 0.6249110320284726 0.4765904138979524 0.6336538108668481 1.0 0.9805773380862556 2 P78540 1 +Positive regulation of calcium ion transmembrane transporter activity 0.4073772076312205 0.4755248202918924 0.6344129465163837 1.0 0.9812929859876564 10 P78417 1 +Anterior head development 0.6245551601423447 0.4754384363629904 0.6344745038446844 1.0 0.9812929859876564 2 Q13206 1 +Chondrocyte differentiation 0.4190492452803677 0.474768690049359 0.6349518519185178 1.0 0.9812929859876564 9 Q16539,Q06124,Q92896 3 +Response to amine 0.500844488666456 0.4746113177463156 0.635064037861709 1.0 0.9812929859876564 5 P23378 1 +Negative regulation of antigen receptor mediated signaling pathway 0.5797386371301192 0.4745219611759841 0.635127741181237 1.0 0.9812929859876564 4 Q96IZ0 1 +Negative regulation of t cell receptor signaling pathway 0.5797386371301192 0.4745219611759841 0.635127741181237 1.0 0.9812929859876564 4 Q96IZ0 1 +Response to glycoside 0.6231316725978606 0.4708419310797229 0.6377536184255801 1.0 0.9832478275587462 2 O96017 1 +Cellular carbohydrate metabolic process 0.3027464599401539 0.4679304895051817 0.6398342989382078 1.0 0.9834781485711834 53 P16278,O75874,P31751,P62136,P35573,O43505,P10253,P08236,Q14108,O75844,P13807,Q9NUJ1,Q9BYT8,P48735 14 +Photoreceptor cell development 0.577610867559059 0.4676976185166807 0.6400008443896534 1.0 0.9834781485711834 4 P54802 1 +Positive regulation of mitotic cell cycle phase transition 0.3208086664842978 0.4673904646032945 0.6402205434928363 1.0 0.9834781485711834 30 O75179,Q9UJX4,P04083,Q96ST3,Q9UJX3,Q96DY7,Q9UJX2,P31350 8 +Rna decapping 0.5766463589872652 0.4646148993718765 0.6422072605565243 1.0 0.983855435522062 4 Q96C86 1 +Methylguanosine cap decapping 0.5766463589872652 0.4646148993718765 0.6422072605565243 1.0 0.983855435522062 4 Q96C86 1 +Taxis 0.3039565634962755 0.4628087698261023 0.643501444569941 1.0 0.983855435522062 52 Q16539,Q9BW27,Q8TEY7,P11233,Q7L576,P14174,Q4VCS5,Q02750,P04792,P04083,P35613,P42892,Q9BVA1,Q9NUQ9,P46109,O00264,P17931 17 +Macrophage activation 0.4546653219779615 0.4619765336238403 0.6440981487262296 1.0 0.983855435522062 6 P15260 1 +Regulation of intrinsic apoptotic signaling pathway in response to dna damage 0.404513594357153 0.4619561002130102 0.6441128021432985 1.0 0.983855435522062 10 Q96K76,P61978 2 +Defense response 0.3164744612155684 0.461869476169374 0.6441749244016535 1.0 0.983855435522062 190 Q9NRW3,P15260,P68371,P14174,P08670,P42785,Q9UKG1,P04083,O00743,P43243,Q14258,Q9BQE5,P04439,Q16543,Q16539,O00584,P01889,Q9NZ08,O43823,Q14671,O75844,O60684,Q06330,Q53EL6,P10321,O60506,O75179,Q8IV08,Q9NUD5,P49327,P09601,Q9Y263,Q9UNH7,P04062,Q9HCE1,Q9BYW2,Q96ST3,Q96KB5,P17931,Q06124,Q9H000,Q5KU26,Q06481,P28070,O94992,Q01085,P19474,Q08380,P07437,Q8IXJ6,Q9Y624,P60900,O43657,Q96PK6,P42345 55 +Leukocyte cell cell adhesion 0.3173110133328667 0.4616838410580739 0.6443080606176763 1.0 0.983855435522062 36 Q9Y624,Q96IZ0,Q92990,P04083,Q06124,Q9NUQ9,P17931,P04439 8 +Regulation of secretion 0.2874205241533827 0.4610891179766757 0.6447346687128173 1.0 0.983855435522062 84 Q32P28,Q7L0J3,Q06787,Q16850,Q92783,Q16836,P11233,O14964,P14174,P35080,P09601,P04083,P53985,O14936,Q06124 15 +Negative regulation of histone acetylation 0.4961559277374286 0.4579259430097208 0.6470056476599133 1.0 0.9864884897155752 5 Q01105,Q96ST3 2 +Negative regulation of cell aging 0.5735507690562761 0.4547667944656778 0.649277021483794 1.0 0.9890549243131735 4 P67809 1 +Negative regulation of cellular protein catabolic process 0.3245545581427602 0.4536024508513729 0.6501149891814686 1.0 0.9893925901674896 24 Q9H2J4,P46379 2 +Regulation of histone h2b ubiquitination 0.5726065457531125 0.4517769983590579 0.6514296417718202 1.0 0.9899543500978476 4 Q5VTR2 1 +Histone lysine demethylation 0.4942037286595347 0.4510306880098424 0.6519674313932562 1.0 0.9903455672864598 5 Q8NB78 1 +Phosphatidylglycerol metabolic process 0.4020869759531041 0.4505268093647583 0.6523306276550684 1.0 0.9903735475443624 10 Q8NCC3 1 +Lipid droplet formation 0.5718876883484223 0.4495052700607541 0.6530672072374926 1.0 0.9911061399360503 4 Q9Y679 1 +Neurotrophin signaling pathway 0.4934995508669058 0.4485511816327343 0.6537554570022799 1.0 0.9911061399360503 5 Q06124 1 +Neurotransmitter secretion 0.3425176157077827 0.4472075409038881 0.6547252171752798 1.0 0.9911061399360503 21 Q06787,P50897,O95721,O14936,Q7L0J3 5 +Regulation of actomyosin structure organization 0.3605529237426114 0.4460781355123375 0.6555408059402175 1.0 0.9911061399360503 17 P09493,Q07157,P63167,P35080,P07737,Q9Y624,P42345 7 +Regulation of epithelial to mesenchymal transition 0.4927739921227667 0.4460006913010883 0.6555967465668897 1.0 0.9911061399360503 5 Q92769 1 +Negative regulation of proteasomal protein catabolic process 0.3630917327977093 0.4457750132338458 0.6557597726422848 1.0 0.9911061399360503 16 P46379 1 +Regulation of synaptic plasticity 0.3166710391098287 0.4457738924857015 0.6557605822930035 1.0 0.9911061399360503 25 Q06787,Q92542,Q8IUD2,Q14168,Q9UQB8,Q9BPZ3,Q13501 7 +Positive regulation of transport 0.3073484866141736 0.4455380008267135 0.6559310041136506 1.0 0.9911061399360503 158 P30536,Q9Y282,P14174,P55786,Q9UKG1,P04083,O75312,Q03164,P50402,Q9Y5X3,Q9BZF1,O14737,Q9Y4C2,Q07666,P50897,Q92783,O43865,P78417,Q9P2W9,P61978,P08183,Q06124,P30419,Q06787,P42858,P31751,O14964,Q06481,Q07954,O14936 30 +Positive regulation of organelle organization 0.2961354538477091 0.4446090202854463 0.6566023276534523 1.0 0.9911061399360503 130 Q9UK61,Q9Y3I1,P21796,O60216,P04083,Q9UQB8,P07737,P62993,Q9UJX2,P22626,Q8N2A8,P11233,Q96A26,Q14247,O15260,O14737,Q13042,P36404,Q15555,Q9P2W9,Q96ST3,Q9UJX3,Q14103,P30419,Q7L576,O00429,Q9UJX4,P42858,P31751,Q96R06,P35080,Q8IXJ6,P42345 33 +Histone h3 k14 acetylation 0.4213727571189839 0.4445417612697537 0.6566509428457123 1.0 0.9911061399360503 8 Q03164 1 +Regulation of t cell receptor signaling pathway 0.4920801081657679 0.4435656531711849 0.657356642765996 1.0 0.9911061399360503 5 Q96IZ0 1 +Endoplasmic reticulum organization 0.3150820600299303 0.4435451507763016 0.6573714687253238 1.0 0.9911061399360503 37 O43765,Q9NQC3,O14976,P46379,Q9P2W9,O95197,Q8NFQ8 7 +Protein localization to synapse 0.4119772803956137 0.4428096034719959 0.657903456436224 1.0 0.9911061399360503 9 Q14168,Q9UQB8 2 +Positive regulation of nuclear division 0.3878499770199896 0.4410171722728052 0.6592005651595512 1.0 0.9911061399360503 11 Q8IXJ6,Q9UJX3,Q9UJX4,Q9UJX2 4 +Negative regulation of mapk cascade 0.3169735516385971 0.4404370998038923 0.6596205595999209 1.0 0.9911061399360503 27 P78318,P30086,O75832,P04062,Q96KB5,Q53EL6 6 +Fibroblast migration 0.3655226465481039 0.4400842604504543 0.6598760811558921 1.0 0.9911061399360503 14 Q9UKG1,Q5SNT2,Q06481 3 +Defense response to symbiont 0.2970249243505327 0.4395425814679882 0.6602684350633217 1.0 0.9911061399360503 57 Q9NRW3,O75179,Q9BYW2,P15260,Q9NUD5,P19474,Q14671,O75844,O43657 9 +Regulation of glial cell differentiation 0.4111116166526697 0.4389328798686287 0.6607101714963868 1.0 0.9911061399360503 9 Q92769,P42345 2 +Negative regulation of protein binding 0.3561742901464578 0.4388233222137265 0.6607895599226468 1.0 0.9911061399360503 18 Q9NVN8,Q8TEY7,P62136,Q92797,P30533,P10586 6 +Regulation of wound healing 0.3803961129498832 0.437803214245947 0.6615289407404279 1.0 0.9915339093279796 12 P04083,O14936,P42345 3 +Negative regulation of cellular response to insulin stimulus 0.4480789378881554 0.4364928886713148 0.6624791576606541 1.0 0.9924658208263748 6 Q9HCD5,Q06481 2 +Extrinsic apoptotic signaling pathway via death domain receptors 0.3789321768151272 0.4304792910858669 0.6668470277563339 1.0 0.994711579674841 12 Q9NR28,P09601,Q99523 3 +Fatty acid beta oxidation using acyl coa oxidase 0.5657507485820279 0.4302714938846332 0.6669981606842181 1.0 0.994711579674841 4 Q15067,O15254 2 +Negative regulation of cell cycle 0.2909588954234489 0.4301242740641348 0.6671052432719056 1.0 0.994711579674841 78 Q9Y3I1,O60216,Q08J23,Q8N6R0,Q16539,Q13564,Q96FV9,Q12888,Q53EL6,O43670,Q9NXR7,Q9Y619,Q96K76,Q96DY7,Q7L7X3,Q06124,O94992,Q96PK6,Q96RU2 19 +Regulation of phospholipid biosynthetic process 0.4872967680821745 0.4268907684188954 0.6694588897811915 1.0 0.9947878189943588 5 O75874 1 +Positive regulation of muscle cell apoptotic process 0.4172239273289611 0.4267719438421933 0.6695454434269354 1.0 0.9947878189943588 8 P98175,P45985 2 +Negative regulation of inflammatory response to antigenic stimulus 0.487246324375043 0.4267159712767179 0.6695862162236996 1.0 0.9947878189943588 5 Q9H000,P28070 2 +Negative regulation of locomotion 0.313851919162662 0.4265866511115627 0.6696804222549999 1.0 0.9947878189943588 34 P14174,Q9BZF1,P35080,P09601,Q96G23,Q9Y4C2 6 +Homeostatic process 0.3128946360551542 0.4249322068712898 0.670886095540725 1.0 0.9952592423237414 268 P30536,Q9NQC3,P14174,Q5BJF2,P42785,P04083,O15254,O75503,Q9UIQ6,P53985,P30519,Q8WTV0,Q8NF37,Q9Y487,Q93050,O15260,P10253,P62942,Q8N511,P50897,Q15555,P78417,P09601,O15118,P04062,Q06124,Q7L7X3,Q8NE01,Q9HD20,O14773,Q07820,P42858,Q9Y6C9,Q06481,Q15904,P62995,Q9Y624,Q7L0J3 38 +Formation of translation preinitiation complex 0.4248488160452635 0.4243125146839501 0.6713379135400241 1.0 0.9952592423237414 7 P55010 1 +Negative regulation of axonogenesis 0.4865431590922637 0.4242816884131897 0.6713603920986595 1.0 0.9952592423237414 5 Q8N0X7 1 +Signal transduction in response to dna damage 0.3087194303053953 0.423025785722023 0.6722764478418242 1.0 0.9952592423237414 45 Q16539,Q7L7X3,O75832,Q96RU2,P14174,Q96FV9,Q9NXR7,P62993,O75844,Q06124 10 +Regulation of synaptic vesicle exocytosis 0.3960825012885097 0.4225304761063896 0.6726378607223404 1.0 0.9952592423237414 10 O14936,Q06787 2 +Negative regulation of amyloid beta clearance 0.563167195611719 0.422262032578837 0.6728337676941998 1.0 0.9952592423237414 4 Q16850 1 +Response to calcium ion 0.3441891074552212 0.4214021061750486 0.6734614814647839 1.0 0.9952592423237414 20 Q99829,Q14103,Q9UJS0,O43865,P50995,Q92542 6 +Ameboidal type cell migration 0.2952041513731246 0.4194129316384294 0.6749143748664781 1.0 0.9952592423237414 69 Q16539,Q9NQC3,Q8WTV0,Q15555,Q4VCS5,P35080,P42785,Q9UKG1,P04083,P09601,P04792,Q06481,P07737,Q13685,Q5SNT2,P42345,Q06124 17 +Regulation of trans synaptic signaling 0.3025780929411561 0.4192825698819261 0.6750096335053648 1.0 0.9952592423237414 50 Q06787,Q92542,Q9UJX6,O14936,P35080,Q8IUD2,Q14168,Q9UQB8,Q9BVA1,Q9BPZ3,Q13501 11 +Entrainment of circadian clock 0.4850431759941535 0.4191034657225192 0.6751405179439793 1.0 0.9952592423237414 5 Q9BWF3 1 +Photoperiodism 0.4850431759941535 0.4191034657225192 0.6751405179439793 1.0 0.9952592423237414 5 Q9BWF3 1 +Positive regulation of interleukin 2 production 0.4433132836578305 0.4183027030418059 0.6757258135993125 1.0 0.9952592423237414 6 P04083 1 +Regulation of neurotransmitter levels 0.3144454307004828 0.418252904323551 0.6757622190945964 1.0 0.9952592423237414 29 Q06787,P50897,P21964,O95721,O14936,Q7L0J3 6 +Cation transmembrane transport 0.2821940776369481 0.4175447626249223 0.6762799901287724 1.0 0.9952592423237414 107 Q9HD20,P42858,P78417,Q70HW3,P21796,O43772,Q9Y619,Q96ES6,P47985,P62942,P36543,O75964 12 +Calcium ion transmembrane transport 0.3117387295555096 0.4156076354822172 0.6776971385160939 1.0 0.995957042387868 37 P78417,P62942,P21796,P42858 4 +Cilium organization 0.3021179405450487 0.4148664951850703 0.6782396382855542 1.0 0.9962922085803332 50 A6NIH7,Q8WXW3,Q15555,P42858,Q66K14,O95721,Q9BW83,Q9H223 8 +Regulation of hydrolase activity 0.3031556481360291 0.4146265855370539 0.6784152830699068 1.0 0.9963192697135572 152 P30086,Q15392,P29375,P04083,P07858,P25788,Q96A26,O95831,Q5H9R7,O14737,P62942,P46109,P36404,P50897,P61289,Q15555,Q9NR28,Q92542,Q4VCS5,P49327,Q99523,P16435,Q14108,Q96K76,P17931,P78318,Q9Y2S7,P07602,P42858,P31751,Q07954,Q66K14,Q9UJX6,Q06481,Q9UL46,Q9Y624,P42345 37 +Protein maturation by protein folding 0.4420347275841071 0.413459549558252 0.6792699529005948 1.0 0.9967908993269384 6 P62942 1 +Cellular response to vascular endothelial growth factor stimulus 0.5598087185320794 0.4119299663623289 0.6803907558663871 1.0 0.997371320824727 4 P04083,P04792 2 +Dna replication initiation 0.3424834022307381 0.4108181606564207 0.6812058756116444 1.0 0.9980230968733974 20 Q9UFC0 1 +Peptidyl lysine acetylation 0.3061788402372954 0.4084572465797122 0.6829380124182269 1.0 0.9990254350633204 46 Q03164,Q86UY6,P46379 3 +Apoptotic signaling pathway 0.2895625516485195 0.4067860620249411 0.684165124531005 1.0 0.9996019992673472 122 P16989,P62136,P14174,P45880,Q96A26,O95831,O95470,Q14247,P46379,O14737,P30154,O76024,O95881,P61289,Q9NY61,Q9NR28,P49327,P09601,Q99523,P61978,O60443,Q96K76,P17931,P30419,O00429,Q07820,P42858,O75832,Q96IZ0,P30153,P04792,Q96RU2 32 +Serine family amino acid biosynthetic process 0.4398588773262792 0.4052543967299876 0.685290523851197 1.0 0.9996019992673472 6 P00374 1 +Cell projection organization 0.3154326832801898 0.4047841079719325 0.6856362113648173 1.0 0.9996019992673472 211 P30536,Q99829,A6NIH7,Q9NQC3,P51116,P08670,Q9UQB8,P07737,O75312,O00471,Q96G23,O95684,O00264,Q8TEY7,P11233,O95721,P51114,P46109,Q8WXW3,Q9BW27,Q15555,Q99873,Q8N0X7,Q12955,Q14108,P42892,Q86X55,P04062,Q96ST3,Q9BW83,Q9H223,Q7L7X3,Q32P28,Q06124,Q06787,P42858,Q92769,O14976,Q9UJX6,Q66K14,Q02750,Q06481,P35080,P35613,P00374,Q9BVA1,P61421 47 +Proteasomal protein catabolic process 0.2959854168301621 0.4038406916370818 0.6863298714457482 1.0 0.9996019992673472 136 O75477,P49721,Q14258,Q9UJX2,Q9UBS8,P25788,P28072,P46379,Q92990,Q13042,P49720,O76024,O43765,Q8TCT9,P61289,P28074,Q99436,P04062,Q96KB5,Q9UJX3,Q9Y679,Q06787,O75832,Q9UJX4,P20618,Q9H000,Q8N3C0,P28070,Q9UL46,Q8IXJ6,P60900 31 +Negative regulation of peptidyl lysine acetylation 0.4195411285025174 0.402769326944028 0.6871179278536474 1.0 0.9996019992673472 7 Q01105,Q92769,Q96ST3 3 +Icosanoid biosynthetic process 0.4023929706381429 0.4003466385170984 0.6889012212532732 1.0 1.0 9 P14174,Q9H7Z7,P04083,P09960 4 +Regulation of insulin secretion 0.3494623919491412 0.3994454634062576 0.6895650005989493 1.0 1.0 18 P53985 1 +Regulation of chromosome separation 0.3113697931502946 0.399109244137011 0.689812711160718 1.0 1.0 27 Q9UJX4,O60566,P49454,O60216,Q9Y6A5,Q13042,Q9UJX3,Q9H1A4,Q9UJX2,O43670 10 +Cellular response to dsrna 0.437736399605469 0.3972961303948297 0.6911491005729065 1.0 1.0 6 Q9NUD5 1 +Positive regulation of cell population proliferation 0.2771540931980057 0.3971417467451916 0.6912629364731482 1.0 1.0 101 P30536,Q9H2J4,Q9NQC3,P31751,P14174,P09601,P43490,P04083,P55209,Q86X55,P43307,O95684,P04439 13 +Regulation of receptor signaling pathway via stat 0.4181131906566146 0.3970242949671512 0.6913495450658764 1.0 1.0 7 O14964,Q8WXW3,Q6IA86 3 +Epithelial cell apoptotic process 0.3784852784522984 0.3957890140865264 0.692260681940732 1.0 1.0 11 O76024,Q53EL6,O00471,P09601 4 +Positive regulation of cell division 0.3779835044653902 0.3933984884908491 0.6940251858653106 1.0 1.0 11 P67809,Q9Y2S7 2 +Positive regulation of skeletal muscle tissue development 0.6304768767834462 0.3930380050236958 0.6942914115646526 1.0 1.0 3 Q13131 1 +Positive regulation of muscle tissue development 0.6304768767834462 0.3930380050236958 0.6942914115646526 1.0 1.0 3 Q13131 1 +Cardiolipin acyl chain remodeling 0.5978647686832685 0.3924627931846616 0.6947162974323895 1.0 1.0 2 P40939 1 +Response to catecholamine 0.3712181798299593 0.3923744701769684 0.6947815465871516 1.0 1.0 12 Q92542,Q92769,Q96ST3 3 +Negative regulation of lymphocyte differentiation 0.4360183638465534 0.3908879319586862 0.6958800746334313 1.0 1.0 6 P04083 1 +Dna deamination 0.5525359361782378 0.3898742079871448 0.6966295667886819 1.0 1.0 4 Q9NRW3 1 +Anoikis 0.4355969872184598 0.3893208666687771 0.697038802188171 1.0 1.0 6 Q07820 1 +Cristae formation 0.4081575028085896 0.3885802680592405 0.6975866656765008 1.0 1.0 8 Q9Y512 1 +Mitotic cell cycle phase transition 0.2811341090898671 0.3870563204311292 0.6987145133947206 1.0 1.0 109 Q07864,Q9Y3I1,O60216,Q9UKG1,P04083,O00743,O75312,Q9H1A4,Q9UJX2,Q13564,O60566,P18074,Q9Y6A5,Q13042,Q9UN37,Q07666,O43670,P31350,O75179,P61289,Q9NXR7,Q9Y619,P08183,Q96ST3,Q96K76,Q9UJX3,Q96DY7,O43633,Q7L7X3,Q9UJX4,Q06481,Q9UL46,Q8IXJ6,P49321,Q16531 35 +Nuclear pore organization 0.3700731945965337 0.3867915226276784 0.698910553667845 1.0 1.0 12 P57740,Q9BTX1,Q9NQC3 3 +Extracellular vesicle biogenesis 0.3878474092520672 0.384839128703595 0.7003566070676968 1.0 1.0 10 O14964,Q92905,Q92783,O43633 4 +T cell receptor signaling pathway 0.3466613260806799 0.3832547617355165 0.7015308779959837 1.0 1.0 18 Q96IZ0,P46109,Q07666,P04439 4 +Positive regulation of protein localization to membrane 0.3077626065483536 0.3817087700157679 0.7026773942564946 1.0 1.0 25 P30419,P31751,Q12955,O14737,Q9Y4C2,Q07954,Q13501,O00264 8 +Negative regulation of lymphocyte apoptotic process 0.6260464443128699 0.3808755677499741 0.703295582611374 1.0 1.0 3 P14174 1 +Negative regulation of leukocyte apoptotic process 0.6260464443128699 0.3808755677499741 0.703295582611374 1.0 1.0 3 P14174 1 +Protein localization to cell junction 0.3488041932353938 0.3793759572775853 0.7044087018050824 1.0 1.0 17 Q14168,Q9Y624,P04792,Q9UQB8 4 +Response to tumor necrosis factor 0.308782838241501 0.3775530748494068 0.7057626295837087 1.0 1.0 28 Q99829,Q16539,P78318,P16989,Q16822,P49327,P04062,O60443 8 +Negative regulation of blood circulation 0.6233535065859768 0.3735619231702001 0.7087302671093723 1.0 1.0 3 P30626,P16615 2 +Positive regulation of blood circulation 0.6233535065859732 0.3735619231701903 0.7087302671093796 1.0 1.0 3 P09493,P16615 2 +De novo protein folding 0.3447505719161922 0.3722968550621907 0.7096718399063788 1.0 1.0 18 O14976,Q99543,P62942 3 +Heart process 0.3070726789119837 0.3718737562175555 0.7099868456053398 1.0 1.0 26 O75844 1 +Cell activation involved in immune response 0.306024440451091 0.369825547133089 0.7115124788381666 1.0 1.0 35 Q5RKV6,P17931,Q96FV9,Q96FZ2,Q12888,P09601,P04083,O96028,Q9UNH7,Q9UQ84,Q07954,P42345,P13051 13 +Transition metal ion transport 0.3844892498827423 0.3697199417314352 0.7115911716824785 1.0 1.0 10 O15173 1 +Negative regulation of actin filament polymerization 0.3442217093331886 0.3692766225815275 0.7119215485710555 1.0 1.0 18 Q9NUQ9,P35080,Q96S97 3 +Regulation of transporter activity 0.3051845940239825 0.3689499435347526 0.7121650358055851 1.0 1.0 41 P42858,O43865,P78417,P62942,P08183,Q03164,Q9Y4C2 7 +Neuron projection guidance 0.3469106767304664 0.3688591204508597 0.7122327351740465 1.0 1.0 17 Q9BVA1,O00264,P42892 3 +Sperm dna condensation 0.5896797153024851 0.3684642072290791 0.7125271291662174 1.0 1.0 2 Q96SB4 1 +Regulation of protein stability 0.27191983957834 0.3681078722094936 0.7127928012269584 1.0 1.0 96 Q32P28,Q16543,Q9H2J4,P10619,Q9NQC3,Q8TEY7,P42858,O75718,Q9NVN8,P46379,P35080,P48449,P19474,Q96K76,Q07666,Q96RU2 16 +Insulin secretion 0.3241904469125576 0.3669254964424969 0.7136745925171493 1.0 1.0 22 P04083,P53985,Q06124 3 +Regulation of osteoblast differentiation 0.4691841824011307 0.365628448897734 0.7146423437055311 1.0 1.0 5 O00299,P17612,P35222,P17844 4 +Negative regulation of phosphoprotein phosphatase activity 0.4677717274494071 0.3609842143700427 0.7181112476771971 1.0 1.0 5 P62942 1 +Protein localization to golgi apparatus 0.4085032359362422 0.3589520240446787 0.7196309799203822 1.0 1.0 7 O14976 1 +Inner ear receptor cell development 0.4269389286352248 0.3575410971934109 0.7206867654901334 1.0 1.0 6 P54802 1 +Positive regulation of execution phase of apoptosis 0.5415774189283964 0.3575022479947582 0.7207158435875305 1.0 1.0 4 Q8IXJ6,P63167 2 +Positive regulation of intracellular transport 0.2899119799747459 0.3572419589362468 0.7209106768272369 1.0 1.0 60 Q15154,Q16539,P50402,P30419,Q9Y3B8,Q9Y282,P31751,Q9Y2F5,P55786,Q99496,Q9P2W9,Q12955,Q96R06,O14737,Q9Y4C2,O75312,Q07666,Q9NW64 18 +Regulation of regulated secretory pathway 0.3444008076166538 0.355026396568794 0.7225698160945961 1.0 1.0 17 O14936,Q06787,P09601 3 +Respiratory electron transport chain 0.2992152914580372 0.3543022078300096 0.7231124133228617 1.0 1.0 47 P21912,O43676,O75306,P47985,P04062 5 +Camera type eye development 0.3100382678841289 0.3530290555396473 0.7240666580073243 1.0 1.0 24 P54802,P08670,Q15555,Q8NF37 4 +Regulation of mitochondrial fusion 0.4653306611165826 0.353005792704083 0.7240840978089449 1.0 1.0 5 Q8N2A8 1 +Response to interleukin 1 0.3802250030528975 0.3507435754487952 0.7257807312903668 1.0 1.0 10 P04083,P38159 2 +Regulation of release of cytochrome c from mitochondria 0.3799153280092878 0.3493754550972671 0.7268074577416588 1.0 1.0 10 Q96A26,O14737 2 +Positive regulation of neutrophil migration 0.614182127164562 0.3491143572612281 0.7270034583632135 1.0 1.0 3 O00429 1 +Positive regulation of granulocyte chemotaxis 0.614182127164562 0.3491143572612281 0.7270034583632135 1.0 1.0 3 O00429 1 +Regulation of keratinocyte proliferation 0.537889691486168 0.346851995224652 0.7287025125420914 1.0 1.0 4 O14936,P58107 2 +Keratinocyte proliferation 0.537889691486168 0.346851995224652 0.7287025125420914 1.0 1.0 4 O14936,P58107 2 +Eye morphogenesis 0.3978573042795319 0.3463510259958196 0.7290789255682286 1.0 1.0 8 P54802 1 +Positive regulation of cold induced thermogenesis 0.3547836117629324 0.3462586336664763 0.7291483534880072 1.0 1.0 13 Q06481,Q16836 2 +Glycoprotein biosynthetic process 0.3024844497590807 0.34615010048731 0.7292299132347089 1.0 1.0 41 Q7LGA3,Q86SF2,P04844,Q9Y287,P46977,Q92542,Q96IZ0,Q10472,O43505,O15118,O60502 11 +Lipid storage 0.3463322440050438 0.3458700626539913 0.729440368238012 1.0 1.0 15 Q9Y679,Q8WTV0,P17900,P04062 4 +Coronary vasculature development 0.5373571523718775 0.3453244430880404 0.7298504726837955 1.0 1.0 4 Q15750 1 +Positive regulation of histone deacetylation 0.3974805154007139 0.3448312431393399 0.7302212434336897 1.0 1.0 8 Q9ULX6 1 +Mammary gland epithelium development 0.4232648127877254 0.3443056081320929 0.7306164671624737 1.0 1.0 6 P31751 1 +Receptor mediated endocytosis 0.2980721278171857 0.3440061540886844 0.7308416579461152 1.0 1.0 47 Q06787,P50897,P11717,Q5VW38,O14976,Q96D71,P61978,Q14108,Q07954 9 +Protein refolding 0.3674117245665164 0.343876417551549 0.7309392276075672 1.0 1.0 11 O60884,P62942 2 +Positive regulation of tumor necrosis factor superfamily cytokine production 0.3671909314287066 0.3428600730265215 0.7317037301901888 1.0 1.0 11 P14174,P15260,Q92769,Q06124 4 +Regulation of antigen receptor mediated signaling pathway 0.42275248273019 0.3424723047104193 0.7319954829180606 1.0 1.0 6 Q96IZ0 1 +Dendritic transport 0.4620591378696011 0.3424099936314712 0.7320423687209372 1.0 1.0 5 P33176,Q00577,Q14254,Q00839 4 +Olefinic compound metabolic process 0.3450979085706632 0.3395294057484592 0.7342109487158326 1.0 1.0 15 P07099 1 +Establishment of protein localization to endoplasmic reticulum 0.3252929362189777 0.3387058000409313 0.7348313708780632 1.0 1.0 21 Q15629,P46379,O43765 3 +Tissue development 0.31194604778642 0.3385781548656552 0.7349275414877878 1.0 1.0 226 Q9NQC3,P42345,P16989,P62136,Q9UK61,Q15392,P29375,Q14126,P21796,P60660,P08670,O60869,P04083,P10644,Q08J23,P07737,P62993,O00471,Q9C0B1,P09960,P07858,Q16539,P50402,Q07157,P11233,P18074,Q92990,P21266,P43490,P10253,O15173,P62942,P51648,Q6P4Q7,O75844,Q06330,Q53EL6,Q99873,Q15417,P58107,P49327,P20073,Q8N0X7,O15270,P42892,Q96S97,Q99729,Q9BYW2,P17931,Q06124,Q92896,P67809,O14773,P07602,Q92769,P31751,Q02750,P14649,P31942,O95983,Q96PZ0,P35613,P07437,Q8IXJ6,Q9Y624,Q9BYT8 66 +Positive regulation of metaphase anaphase transition of cell cycle 0.3956320896505983 0.3374022068468446 0.7358137212668536 1.0 1.0 8 Q13042,Q9UJX3,Q9UJX4,Q9UJX2 4 +Mitochondrial electron transport nadh to ubiquinone 0.3303726341994216 0.3373807534048029 0.7358298915832868 1.0 1.0 20 O75306,O43676 2 +Mrna modification 0.3596833270228338 0.3370618941506944 0.7360702423366381 1.0 1.0 12 Q96PZ0,Q08J23,Q99729 3 +Regulation of proteolysis 0.2929792640445189 0.337004733414223 0.736113331871513 1.0 1.0 140 P30086,Q9H2J4,Q15392,P07858,P25788,Q96A26,Q92990,P46379,O14737,O43765,Q9NR28,Q92542,P04062,Q96K76,Q96KB5,Q92896,P78318,Q06787,O75832,Q92769,Q9H000,Q06481,P19474,Q9UL46,Q07954 25 +Positive regulation of protein phosphorylation 0.2822378936074769 0.336154540676279 0.7367543314305016 1.0 1.0 79 Q13432,P51116,P14174,Q9BZF1,P51114,P46109,Q8WXW3,Q15750,Q13501,Q9H223,Q06124,Q7L7X3,Q06787,O75832,Q92769,P31751,Q02750,P35080,Q9H7B4 19 +Positive regulation of mitotic cell cycle 0.301706420405414 0.3336599529849604 0.7386361722305026 1.0 1.0 37 Q9Y2S7,O75179,Q9UJX4,P04083,Q96ST3,Q9UJX3,Q96DY7,Q9UJX2,P31350,Q06124 10 +Single stranded viral rna replication via double stranded dna intermediate 0.3762137212682677 0.3331296590916779 0.7390364120663644 1.0 1.0 10 P52926,Q9UK61,Q9NRW3,Q15047 4 +Sensory organ development 0.2967414483591382 0.3320803078326417 0.7398286192655288 1.0 1.0 47 Q15555,P54802,P42892,O60443,Q9BW83,Q06124 6 +Regulation of transcription from rna polymerase ii promoter in response to hypoxia 0.6075671716597159 0.3319366433583766 0.7399371001929769 1.0 1.0 3 Q8IXJ6 1 +Muscle organ development 0.3013010644174869 0.33100515571999 0.7406405911736722 1.0 1.0 36 Q16539,P50402,P09493,P49454,P16989,P17844,P60660,P14649,Q13131,P62942,Q8IXJ6,P51114,Q06330,Q9BYT8 14 +Regulation of proteasomal protein catabolic process 0.2870200145643626 0.3301122835600057 0.7413151220808274 1.0 1.0 59 O43765,Q06787,O75832,Q9H000,Q8IXJ6,Q92990,P46379,Q9UL46,P04062,Q96KB5,Q9UBS8 11 +Insulin metabolic process 0.6059095763617056 0.3276936147599422 0.7431433317428051 1.0 1.0 3 Q969M3,Q96HE7 2 +Response to angiotensin 0.5307722300134794 0.3266581157420888 0.7439264825791265 1.0 1.0 4 O43865 1 +Regulation of dendritic cell differentiation 0.6052741962456298 0.3260738122416786 0.7443685099493473 1.0 1.0 3 P01889 1 +Negative regulation of transforming growth factor beta receptor signaling pathway 0.3848401330100218 0.3254668938397146 0.744827734737999 1.0 1.0 9 P62942,Q92896 2 +Activation of protein kinase b activity 0.6046725016481922 0.3245432776438177 0.7455267629316122 1.0 1.0 3 Q9BZF1 1 +Glycerophospholipid metabolic process 0.2957696403943815 0.3234119134448834 0.7463833083101006 1.0 1.0 47 Q8WTV0,Q8NF37,Q9Y217,Q9BZF1,Q9NPH0,Q8NCC3,Q99943,P42356,P35790 9 +Schwann cell development 0.4559281162791013 0.3228601707512038 0.7468011413756772 1.0 1.0 5 P31751 1 +Cellular response to leucine starvation 0.6034187202686577 0.3213646646033805 0.7479340576352742 1.0 1.0 3 P42345 1 +Regulation of peptide transport 0.3275920891740025 0.3209791223022114 0.7482262124551669 1.0 1.0 20 P53985 1 +Positive regulation of protein import 0.3411335323094147 0.3193694079186737 0.7494464060521007 1.0 1.0 15 O14737,Q9NW64,O75312 3 +Anterograde axonal transport 0.3418618582240806 0.3188822513924237 0.7498158036154396 1.0 1.0 14 Q14168,Q92572,Q9Y2T2 3 +Antigen receptor mediated signaling pathway 0.3321263725420547 0.318483210587884 0.7501184281806581 1.0 1.0 19 Q96IZ0,P46109,Q07666,P04439 4 +Pyrimidine nucleotide metabolic process 0.3556654968459116 0.3183087624932491 0.7502507382118151 1.0 1.0 12 Q9H773,P17812 2 +Cellular homeostasis 0.2865704224174628 0.3173198543592007 0.7510009136396771 1.0 1.0 129 Q9HD20,P50897,Q07820,P42858,Q7L0J3,Q9NQC3,Q9Y487,P78417,Q93050,P09601,Q15904,P62995,P10253,O75503,Q8N511,Q7L7X3 16 +Meiotic cell cycle process 0.2992990518112219 0.316700337683113 0.7514709925391396 1.0 1.0 35 Q8NI77,Q9BTX1,P52701,Q8IXJ6,P30153,P61160,P46379,O60216,Q08J23,Q92791 10 +Negative regulation of hormone metabolic process 0.5708185053380712 0.3159952761018089 0.7520060936972579 1.0 1.0 2 P05023 1 +Amyloid beta clearance 0.3540250635669514 0.3107333191698875 0.7560033652369689 1.0 1.0 12 Q16850 1 +Platelet aggregation 0.3812147837287579 0.3105196296862716 0.7561658343958853 1.0 1.0 9 Q9Y624,P04792 2 +Tricarboxylic acid cycle 0.3204718079405267 0.3095382673585152 0.756912107312536 1.0 1.0 21 P48735,O75874 2 +Calcium ion export across plasma membrane 0.5683274021352243 0.3093738918385945 0.7570371281820751 1.0 1.0 2 P62258 1 +P38mapk cascade 0.5978583718383509 0.307443048114334 0.7585061660646075 1.0 1.0 3 Q99873 1 +Positive regulation of organelle assembly 0.3145926931020668 0.3066316009912261 0.7591237974949756 1.0 1.0 22 Q15555,Q9P2W9 2 +Regulation of neuron projection development 0.2842995686967946 0.3058484528277075 0.7597200349789146 1.0 1.0 58 Q32P28,Q9NQC3,Q92769,O14976,Q9UJX6,P08670,Q8N0X7,Q02750,Q14108,P46109,Q9UQB8,Q86X55,Q96G23 13 +Response to endogenous stimulus 0.309699066773264 0.3038863531764061 0.7612144750251606 1.0 1.0 236 P30536,Q99829,O75874,Q15392,P08670,P42785,Q9UKG1,P04083,Q9UQB8,O75312,P62993,Q14258,Q9UBS8,P09960,P07858,P16278,Q9Y5X3,Q9BZF1,O43823,P21266,P43490,O14737,O15173,P62942,O75844,Q6RW13,P46109,Q53EL6,O43865,Q92542,Q8N0X7,Q969T9,P09601,Q99523,O15118,Q15750,Q9HCD5,P04062,Q86X55,Q99729,Q96ST3,Q06124,Q92896,Q14103,Q16836,P31751,Q92769,P40818,P35573,Q06481,P35613,Q9H7B4,Q8IXJ6,Q07954,Q92572,Q96PK6,P42345 57 +Histone h2b ubiquitination 0.4116179615110402 0.3034038462897486 0.7615821148267474 1.0 1.0 6 Q5VTR2,Q6PD62,Q8N7H5,O75150,Q9NW82 5 +Negative regulation of cytoskeleton organization 0.29635313327585 0.2984225304111672 0.7653806952434954 1.0 1.0 42 O15344,P29372,Q07157,Q9Y624,Q9UJX6,P35080,P07737,Q96S97,Q9NUQ9,Q96PK6,Q7L7X3 11 +B cell proliferation 0.4100777140281367 0.2981202242591689 0.7656114062766766 1.0 1.0 6 Q96IZ0,P14174 2 +Positive regulation of viral process 0.296280717312278 0.2966128912259095 0.7667620677973253 1.0 1.0 26 Q06787,P11940,Q6PKG0,Q9P035,Q9UIV1,P19474,O60684,Q9UN37,Q16531 9 +Developmental process involved in reproduction 0.2845328835440838 0.296055266877229 0.7671878752341139 1.0 1.0 128 O75874,P16989,O75718,Q15392,Q92674,P04083,Q08J23,P62993,P57740,P07858,Q16539,Q9P0K7,Q8N2A8,O95470,P46379,Q99417,Q14671,P46109,Q07666,Q8NI77,Q9H6E4,Q96PU8,P11717,Q15067,Q4G0J3,Q9BYW2,Q9BPZ3,Q9BW83,Q06124,Q9BTX1,P07602,P30153,Q02750,P35613,Q8IXJ6,Q01085,P42345 37 +Negative regulation of histone modification 0.3332854719161224 0.2953405561389257 0.7677337381637037 1.0 1.0 17 Q01105,P29375,Q96FW1,Q96ST3 4 +Protein acylation 0.2828647096708322 0.2953261206015701 0.767744764546038 1.0 1.0 57 Q03164,Q86UY6,O75844,P46379 4 +Positive regulation of steroid metabolic process 0.592654391626832 0.2946768374791007 0.7682407589085478 1.0 1.0 3 P16435 1 +Positive regulation of steroid biosynthetic process 0.592654391626832 0.2946768374791007 0.7682407589085478 1.0 1.0 3 P16435 1 +Positive regulation of histone modification 0.2973251289673935 0.2937138578473137 0.7689765641172053 1.0 1.0 33 Q03164,Q9ULX6,Q969T9,O43823 4 +Regulation of exosomal secretion 0.3768798652245373 0.2928999781696511 0.7695986055402093 1.0 1.0 9 Q92783 1 +Anatomical structure homeostasis 0.2970798297107102 0.2918840981971692 0.7703752421364638 1.0 1.0 33 Q7L7X3,O14773,Q15555,Q8NF37,Q9Y624,Q06124 6 +Negative regulation of signaling 0.3023294869035918 0.2908002512581682 0.7712040931685078 1.0 1.0 177 Q99829,P30086,P16989,P14174,Q10713,Q9UKG1,P45880,Q16539,P50402,Q96FV9,Q9Y5X3,Q14247,P62942,Q9NPR9,P30533,Q53EL6,O76024,O95881,Q8WXW3,P61289,Q8N0X7,P09601,Q9HCD5,Q96S97,P04062,Q96K76,Q9NUQ9,Q96KB5,Q8N183,P17931,Q06124,Q92896,P78318,Q06787,O75832,Q07820,P42858,Q16836,Q9H000,O14964,Q96IZ0,Q9UJX6,P30153,P04792,Q07954,O43657,P42345 47 +Actin filament polymerization 0.2959231249701299 0.290593150545228 0.7713624992022798 1.0 1.0 35 Q9NUQ9,Q14247,P35080,Q96S97,P07737,P62993,Q9UQB8,P42345 8 +Negative regulation of smooth muscle cell differentiation 0.5174265026751775 0.2901345101034804 0.7717133354606032 1.0 1.0 4 O75179 1 +Er overload response 0.5172592174756618 0.2896881971534024 0.7720547866473524 1.0 1.0 4 O76024,Q96A33 2 +Regulation of endoplasmic reticulum unfolded protein response 0.3902068508914572 0.2895923029876368 0.772128156127927 1.0 1.0 7 O76024,Q92905 2 +Positive regulation of protein deacetylation 0.375568507217584 0.2876257624014662 0.7736332222982489 1.0 1.0 9 Q9ULX6 1 +Membrane protein ectodomain proteolysis 0.3752608354838314 0.2863921526433197 0.7745777843959307 1.0 1.0 9 Q8TCT9,Q9NZ08,P38159 3 +Myeloid cell apoptotic process 0.5152468352638613 0.284342093794813 0.7761482306045957 1.0 1.0 4 P14174 1 +Regulation of myeloid cell apoptotic process 0.5152468352638613 0.284342093794813 0.7761482306045957 1.0 1.0 4 P14174 1 +Attachment of mitotic spindle microtubules to kinetochore 0.4054496771178328 0.2824287453420741 0.7776147761744165 1.0 1.0 6 Q99661,Q96DB5,Q00839 3 +Myeloid leukocyte activation 0.3307868190617806 0.2823014883850152 0.7777123444059089 1.0 1.0 17 P14174,P15260,P09601 3 +Reproductive system development 0.2815126310417152 0.2819956757325957 0.7779468260715774 1.0 1.0 57 Q16539,Q8NI77,Q9BYW2,Q9H6E4,P07602,O75874,P16989,Q15392,O95470,Q02750,P04083,P35613,P62993,P57740,P46109,Q06124,P07858 17 +Regulation of unsaturated fatty acid biosynthetic process 0.5873685277453358 0.281975740796251 0.7779621118742115 1.0 1.0 3 P04083 1 +Positive regulation of binding 0.2938598630278707 0.2816347431590795 0.7782235969195406 1.0 1.0 43 Q9Y2S7,Q06787,Q8TEY7,O60869,P62942,O75503,P19474,Q8IXJ6,Q07954 9 +Negative regulation of microtubule polymerization or depolymerization 0.333927181818483 0.2806108473612876 0.7790088952108789 1.0 1.0 14 O15344,P29372,Q9UJX6,Q14155,Q15691,Q7L7X3 6 +Oogenesis 0.3472406052983121 0.2799257802351118 0.7795344478176585 1.0 1.0 12 Q8N2A8,P30153 2 +Interleukin 2 production 0.3874889419638696 0.2796716474598084 0.779729432665583 1.0 1.0 7 P04083 1 +Angiotensin activated signaling pathway 0.5856913439921773 0.2780026066108262 0.7810103578127812 1.0 1.0 3 O43865 1 +Columnar cuboidal epithelial cell differentiation 0.3870037851313808 0.277911818042601 0.7810800516516019 1.0 1.0 7 P04818,P49327,P07437 3 +Regulation of protein phosphorylation 0.2903469573540504 0.2770167576966169 0.7817672387131465 1.0 1.0 144 Q9H2J4,Q13432,P51116,P14174,Q9Y3I1,O95684,Q16543,Q9BZF1,O43823,P51114,P46109,Q53EL6,Q8WXW3,Q15750,Q96S97,P04062,Q96KB5,Q13501,Q9H223,Q7L7X3,Q06124,Q06787,O75832,P42858,P31751,Q92769,O14964,P30153,Q02750,Q9ULX6,P35080,P04792,O94992,Q9H7B4,Q8IXJ6,Q07954,P42345 37 +Posttranscriptional regulation of gene expression 0.3069438107091111 0.2763453039773617 0.7822828625626119 1.0 1.0 208 Q9H074,Q96B26,P16989,P51116,P62136,P42345,P08670,Q10713,Q13310,P35637,Q08J23,P23588,Q567V2,P43243,Q9Y6M1,P22626,Q9C0B1,Q9BRP8,Q16543,Q16539,P11940,Q969T7,P27635,Q92945,Q14671,P31483,O75844,Q86VM9,P51114,Q8IWR0,Q07666,Q92804,O60506,Q96PU8,Q92615,P55010,O15514,Q71RC2,Q9Y2L1,Q9HCE1,Q9BPZ3,Q9BWF3,Q14011,Q14103,P34897,P67809,Q7L576,P98175,Q06787,Q6PKG0,P31751,Q5KU26,Q02750,P04792,O94992,Q96PZ0,P00374,P98179,Q01085,Q96C86,Q9Y2R0 61 +Positive regulation of protein kinase b signaling 0.3328494653649384 0.2755164255736105 0.7829195081773643 1.0 1.0 14 Q9NQC3,Q9BZF1 2 +Cell cell signaling 0.2937295438230459 0.2750251593157536 0.7832969090295534 1.0 1.0 153 Q13432,P62136,P14174,P04083,Q9UQB8,Q9UIQ6,P53985,P50402,P52294,Q8IUD2,P43490,O95721,P46109,P50897,Q92542,Q14168,Q96K76,Q9BPZ3,Q8N183,Q13501,Q06124,Q06787,Q16836,Q9UJX6,P40818,P35080,Q9BVA1,Q07954,O14936,Q7L0J3 30 +Histone monoubiquitination 0.3519911381079057 0.2748329083765901 0.7834446140459823 1.0 1.0 11 Q16531,Q99496,Q5VTR2 3 +Inorganic ion transmembrane transport 0.2661674735553825 0.2745597242638983 0.7836545128617076 1.0 1.0 98 Q9HD20,P42858,P78417,P21796,Q96ES6,P47985,P62942,Q9UHG3,P36543,O75964,Q9UBX3 11 +Mesenchymal cell differentiation 0.2942877086729715 0.2745387460658042 0.7836706319425946 1.0 1.0 28 Q9NQC3,Q92769,P17844,Q9UK61,Q92841,Q99729,Q06330,Q53EL6,P42345 9 +Bone morphogenesis 0.3794905984631854 0.2745175664133997 0.78368690590971 1.0 1.0 8 O75844 1 +Negative regulation of dephosphorylation 0.345955539942933 0.2741884656910782 0.7839397916343085 1.0 1.0 12 P62942,Q12972 2 +Negative regulation of viral genome replication 0.3394794384008546 0.2739540946533291 0.7841198996220515 1.0 1.0 13 Q9NRW3,P52926,Q12906,Q9UK61,Q15047 5 +Regulation of hormone secretion 0.3036299529261723 0.2732277785071034 0.7846781279172497 1.0 1.0 23 P04083,P53985,Q06124 3 +Type i interferon production 0.2919356235296477 0.273144446599543 0.784742181812407 1.0 1.0 25 Q9NUD5,P19474,Q06124 3 +In utero embryonic development 0.2751570652282318 0.2730441533963587 0.7848192751085343 1.0 1.0 81 Q9NQC3,P16989,Q96AY3,Q08J23,O75312,Q14679,P31350,Q8TCT9,Q99873,Q4VCS5,Q8IWS0,O43772,Q15750,Q9BYW2,P67809,P30419,Q02750,O95983,P23786 19 +Regulation of defense response to virus by host 0.4396152475952864 0.2729105590089002 0.7849219696102685 1.0 1.0 5 Q08211,P07900,P42224,Q96ST3 4 +Regulation of viral process 0.2915785215525399 0.2726017872189639 0.7851593379566704 1.0 1.0 45 Q9NRW3,O60684,P11940,P07237,Q06787,Q6PKG0,Q9UK61,Q12906,Q4G0J3,O94992,Q9P035,Q15047,Q9UIV1,P19474,Q14258,Q9UN37,Q16531 17 +Transcription coupled nucleotide excision repair 0.5105946310790506 0.2721465133915242 0.7855093662036776 1.0 1.0 4 P18074,Q93009 2 +Negative regulation of establishment of protein localization to mitochondrion 0.5537366548042623 0.2721058386300357 0.7855406402983531 1.0 1.0 2 P49257 1 +Positive regulation of cardiac muscle cell proliferation 0.5831765584125773 0.272097171659765 0.7855473042211039 1.0 1.0 3 Q16539 1 +Regulation of cardiac muscle cell proliferation 0.5831765584125773 0.272097171659765 0.7855473042211039 1.0 1.0 3 Q16539 1 +Epigenetic maintenance of chromatin in transcription competent conformation 0.5105498117716856 0.2720301426509607 0.7855988425006295 1.0 1.0 4 Q969T9 1 +Vesicle transport along microtubule 0.3452836830394949 0.2712016822015215 0.7862359192392461 1.0 1.0 12 Q92572,P42858 2 +Regulation of circadian rhythm 0.3032710607959378 0.2710059785016993 0.7863864340940396 1.0 1.0 23 Q14103,Q16531,P62136,Q13131,Q96ST3,Q05086,Q9BWF3,Q93009,P42345 9 +Bone cell development 0.5091705874015937 0.2684596237087441 0.7883455500886904 1.0 1.0 4 Q06124 1 +Negative regulation of defense response to virus 0.4008565667412481 0.2671364693762159 0.789364089055085 1.0 1.0 6 O43657 1 +Centromere complex assembly 0.3836935021921649 0.2659951317288876 0.7902429583263988 1.0 1.0 7 Q92674,P49321 2 +Regulation of intracellular protein transport 0.2812852262451438 0.2655791411659258 0.7905633517900894 1.0 1.0 62 Q15154,Q16539,P50402,P30419,Q9Y3B8,Q9Y282,P31751,Q9Y2F5,P55786,Q99496,Q13131,Q12955,O14737,O75312,Q9UII2,Q9Y4C2,Q9NW64,Q06124 18 +Regulation of stem cell population maintenance 0.437121482009259 0.2655535365815659 0.7905830734460473 1.0 1.0 5 P52926,Q15717,Q15061,Q9Y6J9 4 +Positive regulation of nucleocytoplasmic transport 0.3128597139523159 0.2647168322548693 0.7912276096803925 1.0 1.0 21 Q16539,P50402,Q9Y3B8,O75312,Q07666,Q9NW64 6 +Regulation of cellular response to growth factor stimulus 0.2921940961042428 0.2641576227480356 0.791658463687944 1.0 1.0 27 O14964,O14936,Q8N0X7,P62942,Q9UNH7,Q06330,Q92896 7 +Dsrna processing 0.3294103656326864 0.2617021488203828 0.7935510837391844 1.0 1.0 15 O75844,Q8IWR0,Q02750,P22626 4 +Leukocyte migration 0.2924507699502003 0.2609699647670295 0.7941156694915685 1.0 1.0 37 Q9BW27,P14174,P09601,P04083,P04062,Q9Y624,P46109,P17931 8 +Schwann cell differentiation 0.3984136147110985 0.2591200093887983 0.7955426466557247 1.0 1.0 6 P31751 1 +Oligosaccharide catabolic process 0.5774038546354969 0.2587795230278797 0.7958053580897797 1.0 1.0 3 P17900 1 +Regulation of cytosolic calcium ion concentration 0.3066505555766385 0.2586008077096192 0.795943259978956 1.0 1.0 22 P78417,P42858 2 +Positive regulation of ruffle assembly 0.577148553797558 0.2581982810945488 0.796253884451205 1.0 1.0 3 P07737 1 +Positive regulation by host of viral transcription 0.4342714641966416 0.2572399398473797 0.7969935535808614 1.0 1.0 5 Q12824,O14646,Q13573,Q14684 4 +Epithelial cell proliferation 0.2918361197810327 0.2557727372590643 0.7981263263434466 1.0 1.0 34 O14936,Q8WTV0,P09601 3 +Trna catabolic process 0.3674166717383417 0.2554467461827543 0.7983780697852674 1.0 1.0 9 Q96B26 1 +Regulation of receptor mediated endocytosis 0.3207756776287637 0.2554389053554402 0.7983841250462755 1.0 1.0 19 P61978,Q06787,P50897 3 +Regulation of b cell proliferation 0.5037782367588469 0.2546981909218835 0.7989562136122763 1.0 1.0 4 Q96IZ0,P14174 2 +Regulation of inflammatory response to antigenic stimulus 0.3804876031165023 0.2546080091590331 0.7990258726023776 1.0 1.0 7 Q9H000,P28070 2 +Mitochondrial fission 0.3670444797508918 0.2540032327284284 0.7994930606331987 1.0 1.0 9 Q9NUQ9,Q8TB36,P11233 3 +Maintenance of blood brain barrier 0.4326737137206129 0.25262387655808 0.8005588775272015 1.0 1.0 5 Q9Y624 1 +Female meiotic nuclear division 0.3962936564504556 0.2522307094614782 0.800862742543023 1.0 1.0 6 O95067,Q15645,P30153,P11388,Q15003 5 +Neurotransmitter transport 0.2896078245341145 0.251890950015887 0.8011253549391584 1.0 1.0 26 Q06787,P50897,O95721,O14936,Q7L0J3 5 +Negative regulation of fibroblast proliferation 0.3961068054994053 0.2516265225064999 0.8013297561048143 1.0 1.0 6 Q96IZ0 1 +Regulation of cell population proliferation 0.3019583213015679 0.2514446443481203 0.8014703549231126 1.0 1.0 187 P30536,Q9H2J4,Q9NQC3,P14174,Q15392,Q13363,P04083,P10644,Q96G23,O95684,Q9C0B1,P04439,Q16539,Q15022,O60884,P50402,Q92990,P43490,O14737,O75844,P46109,Q53EL6,Q99873,P09601,P52756,Q86X55,O60443,Q96DY7,P17931,Q32P28,P98175,Q92769,P31751,O14964,Q96IZ0,Q02750,Q06481,Q14534,P55209,Q8IXJ6,Q01085,O14936,P43307 43 +Monocyte differentiation 0.4319961195450419 0.2506760102134589 0.8020646096549686 1.0 1.0 5 O00625 1 +Apoptotic process involved in development 0.5018772839540574 0.2499230892894911 0.8026468270450968 1.0 1.0 4 P30154 1 +Cellular response to estradiol stimulus 0.4315131389208648 0.2492911657551252 0.8031355643662546 1.0 1.0 5 Q14103,Q8NI77 2 +Positive regulation of chromosome separation 0.3656466079114867 0.2486023219609952 0.8036684122140374 1.0 1.0 9 Q13042,Q9UJX3,Q9UJX4,Q9UJX2 4 +Negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway 0.3325912230363704 0.2429542962893119 0.8080408030226813 1.0 1.0 13 Q8N0X7,P62942,Q92896 3 +Phagocytosis 0.2895794821761792 0.2426522735122533 0.8082747827231485 1.0 1.0 35 Q8WTV0,P50995,Q06481,Q9UKG1,P04083,Q12907,Q07954 7 +Regulation of immune system process 0.2967076326473737 0.241713177945622 0.8090024177788366 1.0 1.0 169 Q9NQC3,Q5RKV6,P14174,Q9Y3I1,Q9UKG1,P04083,O96028,P10644,P43243,Q14258,P04439,Q16543,Q16539,Q01650,Q96FZ2,P01889,Q96FV9,Q9NZ08,Q92990,P46379,P62942,Q14671,Q9NPR9,P46109,Q07666,O75179,Q8WXW3,Q99873,P45985,Q9NUD5,P09601,Q96ST3,Q9NUQ9,P17931,Q06124,Q9H000,Q96IZ0,Q5KU26,Q06481,P28070,O94992,P19474,O43657,Q96PK6,P42345 45 +Negative regulation of protein acetylation 0.3703344298980962 0.2405652628712881 0.8098920757892483 1.0 1.0 8 Q01105,Q92769,Q96ST3 3 +Positive regulation of cytokine production involved in immune response 0.3634968577152342 0.2403606199105131 0.8100507041699834 1.0 1.0 9 P14174,P04439 2 +Maintenance of dna methylation 0.4282151763448436 0.2399150006240022 0.8103961516172749 1.0 1.0 5 Q9NRZ9,P49711,Q93009,P26358 4 +Postsynaptic modulation of chemical synaptic transmission 0.4967911705276784 0.2373455799985036 0.8123887043882867 1.0 1.0 4 P40818 1 +Tetrahydrofolate metabolic process 0.3531638177336304 0.2368674855758492 0.8127595949860329 1.0 1.0 10 P04818,P34897,Q9NRN7,P00374 4 +Divalent inorganic cation homeostasis 0.2839386856883546 0.2368665974237657 0.8127602840255634 1.0 1.0 49 Q8NE01,Q9HD20,P42858,P78417,P62942,Q7L0J3 6 +Nik nf kappab signaling 0.3240936353002302 0.2351040390470019 0.8141279838473916 1.0 1.0 14 Q99829,Q9H000,O43707,Q53EL6,O43657 5 +Regulation of protein tyrosine kinase activity 0.3526959404541953 0.235008742865489 0.8142019474144797 1.0 1.0 10 O95684,Q13432 2 +Long chain fatty acid metabolic process 0.3167885794394836 0.2340904560406393 0.8149147550898688 1.0 1.0 19 P07099 1 +Temperature homeostasis 0.2857752622481732 0.2330348340853984 0.8157343565944486 1.0 1.0 25 Q16836,Q06481,Q9UIQ6,P23786,Q9C0B1 5 +Protein acetylation 0.2781324280634221 0.2291901247306664 0.8187211476482499 1.0 1.0 53 Q03164,Q86UY6,P46379 3 +Histone deacetylation 0.2880012632764683 0.2287056083882383 0.8190977354542621 1.0 1.0 29 Q92769,P29375,Q9ULX6,O43823,O95983,Q96ST3,Q8IXJ6,Q96PK6 8 +Regulation of double strand break repair via nonhomologous end joining 0.3665719677870346 0.2270035787351673 0.8204209593808613 1.0 1.0 8 P52926,O96028,P61160 3 +Response to interleukin 7 0.3597246167481912 0.2260904709221731 0.8211310558247786 1.0 1.0 9 P67809 1 +Positive regulation of calcium ion transmembrane transport 0.3285268877707463 0.2251526862909083 0.821860495289511 1.0 1.0 13 P78417 1 +Membrane organization 0.3034483553002121 0.2248090323696441 0.8221278391126992 1.0 1.0 207 P30536,P55735,Q9NQC3,Q9NS69,Q15392,P45880,P04083,Q9UQB8,Q9Y512,Q9BZF1,P46379,Q53EZ4,O14737,O95721,Q15629,O75844,Q8NFQ8,O43765,P50897,Q13505,Q9P2W9,O15118,P08183,P30419,P31751,O14976,O14964,Q86XL3,Q9ULX6,Q06481,Q15437 31 +Negative regulation of cell growth 0.2899401398596049 0.2232532479735532 0.8233384116619744 1.0 1.0 24 Q8N0X7,P50897 2 +Cellular response to calcium ion 0.349393290506779 0.2220046799987892 0.8243102401256632 1.0 1.0 10 Q99829,P46940,O75131,Q92542,P35611,Q13131,Q9Y696,P30405,Q9NXV6 9 +Dopaminergic neuron differentiation 0.5320284697508821 0.2216448266511603 0.8245903836650237 1.0 1.0 2 P55145 1 +Regulation of cellular response to transforming growth factor beta stimulus 0.3335088456593404 0.2203458533050507 0.8256018118019313 1.0 1.0 12 P62942,Q92896 2 +Regulation of cysteine type endopeptidase activity 0.28695580163142 0.2187938678437658 0.8268106239045079 1.0 1.0 40 O14737,Q15392,Q96K76,Q9NR28 4 +Regulation of cell death 0.2909700110442214 0.2179655816554714 0.8274559285350702 1.0 1.0 306 P30536,Q01105,Q9NQC3,Q9NS69,P16989,P62136,P14174,Q15392,Q9Y3I1,P21796,P45880,P04083,O43813,O75312,P07858,P39687,Q13564,Q07157,Q9UMX5,Q96A26,P27635,Q9BZZ5,P52294,O95831,Q14247,P46379,O14737,P30533,Q53EL6,P30154,O76024,O95881,P50897,P61289,P45985,P11717,Q9NY61,Q9NR28,P49327,P09601,P16435,Q9NXR7,Q92905,O15118,P61978,Q9UNH7,P52756,P04062,O60443,Q96K76,Q96ST3,Q8WYA6,Q13501,Q8IYB8,P17931,O43633,P78318,P98175,Q07820,P42858,P31751,O75832,Q96IZ0,Q92769,Q86XL3,P30153,Q9Y6C9,P04792,Q8IXJ6,Q07954,Q96C86,P13051 72 +Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage 0.369549851836954 0.2169470632870983 0.828249599719697 1.0 1.0 7 Q96K76 1 +Deoxyribose phosphate metabolic process 0.3378527625533736 0.2153488146154686 0.8294953737273778 1.0 1.0 11 Q9H773,P31350 2 +Cardiac septum development 0.3373637606591473 0.2133631015500466 0.8310437585361798 1.0 1.0 11 Q15750,O96028,P43243 3 +Regulation of protein binding 0.2863009923770584 0.2132579658472017 0.8311257577679683 1.0 1.0 39 Q9Y2S7,Q9NVN8,Q8TEY7,P35269,P62136,Q92797,P62942,P19474,Q07954,P30533,P10586 11 +Lymphocyte apoptotic process 0.3372740949706176 0.2129995337448622 0.8313273263562486 1.0 1.0 11 P14174,P46109,P17931,P49327 4 +Regulation of t cell apoptotic process 0.555699620208835 0.2117706964812512 0.8322859308320838 1.0 1.0 3 P17931 1 +Heart valve development 0.3832744204215549 0.2113448912041032 0.8326181558273416 1.0 1.0 6 P42345,P43243 2 +Cell communication by electrical coupling 0.382751247327148 0.2097547163009871 0.8338591179062558 1.0 1.0 6 P30626,P05023,Q16643,Q12955,P17612 5 +Inner cell mass cell differentiation 0.5263345195729441 0.2094317439439658 0.8341112140959273 1.0 1.0 2 Q9NVX2 1 +Cellular response to heat 0.2981416013609534 0.2092460087717792 0.8342561974762075 1.0 1.0 22 Q99543,P42345,Q92769,P09601 4 +Epidermis development 0.2855582667576358 0.2076334036902528 0.8355152203492757 1.0 1.0 39 P67809,Q92769,P18074,P29375,Q02750,P04083,P51648,Q08J23,O75844 9 +Hematopoietic stem cell homeostasis 0.4839743589743717 0.2069647988586768 0.8360373497081943 1.0 1.0 4 P55265,Q9NVX2,Q9NX40 3 +Regulation of collagen metabolic process 0.5533230621221735 0.2069251872696483 0.8360682856062787 1.0 1.0 3 P08670 1 +Organelle transport along microtubule 0.2841898649614299 0.2069043235395328 0.8360845798848708 1.0 1.0 28 Q92572,Q9Y2T2,P42858 3 +Cellular carbohydrate biosynthetic process 0.3175972187075894 0.2068404544646427 0.8361344611676473 1.0 1.0 15 P31751,P62136,P35573,O43505,P13807 5 +T helper 1 type immune response 0.5528642460586906 0.2059967094190894 0.8367934816887004 1.0 1.0 3 P04083 1 +T helper 1 cell differentiation 0.5528642460586906 0.2059967094190894 0.8367934816887004 1.0 1.0 3 P04083 1 +Histone h2a monoubiquitination 0.4154841855698956 0.2050670136959616 0.8375197679910824 1.0 1.0 5 Q16531,Q99496 2 +Negative regulation of phosphatase activity 0.381148817875954 0.2049102941331766 0.8376422123184368 1.0 1.0 6 P62942 1 +Regulation of superoxide metabolic process 0.4825664248825925 0.2037447101548448 0.8385530013016633 1.0 1.0 4 P00374 1 +Erad pathway 0.2846447634989654 0.2036529122768624 0.838624741499219 1.0 1.0 34 O76024,Q8TCT9,O43765,Q9Y679,Q96A33,Q8IXB1,P46379,O75477,Q9UBU6,Q14258 10 +Mrna transport 0.2712623422370501 0.2029102918432077 0.8392051498902271 1.0 1.0 78 P55735,Q06787,Q9BW27,Q96ST2,Q96PU8,Q99567,Q9BTX1,Q96FV9,Q8NFH4,Q9ULX6,Q8TD16,Q92945,Q08J23,Q12769,Q9BYW2,P57740,P51991,P22626 18 +Response to mechanical stimulus 0.3127885299273668 0.2012697997188332 0.8404876156749901 1.0 1.0 18 Q16539,P42858,P45985,P49327,Q9Y624 5 +Regulation of protein containing complex assembly 0.2564329572312471 0.1992038060514252 0.8421033222901158 1.0 1.0 92 Q9NUQ9,P45880,Q9UQB8,P04062 4 +Regulation of nik nf kappab signaling 0.3223859876045645 0.198981238807669 0.8422774204024348 1.0 1.0 13 Q99829,O43657,Q9H000 3 +Response to virus 0.2685923120600685 0.1978492837636634 0.8431629853784597 1.0 1.0 81 P61916,Q9Y679,O75179,Q9BYW2,P15260,Q06787,Q9NRW3,Q9NUD5,P04792,P19474,Q14671,Q96ST3,O75844,Q14258,O60443,O43657 16 +Response to ischemia 0.3499821619693238 0.1904128407138795 0.8489856363134747 1.0 1.0 9 Q9UNE7,P04637,P52789,O95831,Q9NQ88,P30405,Q13501,Q15018 8 +Cell cycle g1 s phase transition 0.2774995724783235 0.1903618190456104 0.8490256145568322 1.0 1.0 50 O75179,P61289,Q9Y3I1,Q96DY7,Q06481,Q9UKG1,P04083,O00743,Q9UL46,O75312,Q8N6R0,P49321,Q07666,P31350 14 +Regulation of protein polymerization 0.2750944129436143 0.1897605218394299 0.8494967927445363 1.0 1.0 52 P45880,Q9UQB8 2 +Positive regulation of cellular component biogenesis 0.2595710022478292 0.1896807446300221 0.8495593104344326 1.0 1.0 98 Q9NVN8,Q9UK61,P61160,Q9UQB8,P07737,P62993,P11233,P02786,Q14247,Q9UN37,P36404,Q15555,Q92783,Q9P2W9,Q15047,Q96ST3,P17931,O43633,Q9Y2S7,Q7L576,Q06787,P42858,Q9Y2F5,O14964,Q9H6R0,Q96R06,P35080,Q15691,P42345 29 +Muscle cell migration 0.3408719538187217 0.1894256220807593 0.8497592444630337 1.0 1.0 10 P04083,Q13685 2 +Positive regulation of protein binding 0.3080428752122265 0.1888519314268126 0.8502088687051099 1.0 1.0 19 P19474,Q07954,Q8TEY7,P62942 4 +Peptide transport 0.2805114825243277 0.1879299512995762 0.8509315632927299 1.0 1.0 27 P04083,P53985,Q06124 3 +Immunoglobulin production 0.2840524583195695 0.1877745978262579 0.8510533495357326 1.0 1.0 24 Q5RKV6,Q96FZ2,Q96FV9,Q12888,O96028,Q9UQ84,Q8WYA6,P13051 8 +Biological process involved in symbiotic interaction 0.2722686817605499 0.1860264735915265 0.85242400075106 1.0 1.0 73 O00505,Q8WTV0,O15118,Q14108,P19474,P07858 6 +Negative regulation of growth 0.2775072799399757 0.1813880258497836 0.8560630169721697 1.0 1.0 25 Q8N0X7,P50897 2 +Carbohydrate catabolic process 0.2798119138553446 0.1809391309315001 0.8564153537042372 1.0 1.0 46 P16278,P35573,P10253,P08236,Q14108,Q9NUJ1,P17900 7 +Regulation of neurotransmitter transport 0.3114062065711572 0.1798579594026829 0.8572640804360077 1.0 1.0 14 O14936,Q06787 2 +Establishment of sister chromatid cohesion 0.4707403196006947 0.1776378195031756 0.8590074212078733 1.0 1.0 4 Q9Y6X3,Q7Z5K2 2 +Regulation of histone deacetylation 0.3230106816316921 0.1775486598964589 0.8590774472403309 1.0 1.0 12 Q9ULX6,O43823 2 +Regulation of epithelial cell apoptotic process 0.3364847162077445 0.1732221647118026 0.8624768020714317 1.0 1.0 10 O76024,Q53EL6,P09601 3 +Positive regulation of mitotic nuclear division 0.336344839055517 0.1727121282226357 0.8628777101179197 1.0 1.0 10 Q9UJX3,Q9UJX4,Q9UJX2 3 +Response to electrical stimulus 0.369844255315448 0.1718809874013265 0.8635310939849545 1.0 1.0 6 Q14103 1 +Negative regulation of cellular component organization 0.2856658556697392 0.1697377521525765 0.8652163829252801 1.0 1.0 152 P30536,Q9NVN8,Q9NQC3,Q13432,P08670,O60216,P45880,O15212,P07737,Q96G23,O00264,Q9NQP4,Q07157,P30533,P61758,O43670,O15344,Q8N0X7,Q96S97,Q86X55,P04062,Q9NUQ9,Q96DY7,P17931,Q7L7X3,O75832,Q92769,O14976,Q9UJX6,P35080,Q8IXJ6,Q9Y624,Q96PK6 33 +Telomere capping 0.3347608850820901 0.1669652718792072 0.8673973743283372 1.0 1.0 10 Q14103,P78527,Q92889,P28482,P18887,Q9UBB9,P49959,Q93009,Q9NYB0 9 +Centriole centriole cohesion 0.5322178711285118 0.1665901231768048 0.8676925656601646 1.0 1.0 3 Q14203,Q9C0F1 2 +Ubiquitin dependent erad pathway 0.2787917944200987 0.1653719244780152 0.8686512504239223 1.0 1.0 30 O76024,O43765,Q9Y679,Q96A33,Q8IXB1,P46379,O75477,Q9UBU6,Q14258 9 +Positive regulation of establishment of protein localization to mitochondrion 0.3141588297893344 0.1653584288265231 0.8686618721692776 1.0 1.0 13 O14737,P30419 2 +Regulation of anion transmembrane transport 0.3666071185895195 0.1628026886757231 0.8706737912569409 1.0 1.0 6 Q9Y4C2 1 +Defense response to other organism 0.2805900519058047 0.1626765602994751 0.8707731032958441 1.0 1.0 141 Q9NRW3,P15260,P68371,P14174,P08670,Q9UKG1,P04083,O00743,P43243,P04439,Q16543,O00584,P01889,Q9NZ08,O43823,Q14671,O75844,P10321,O60506,O75179,Q9NUD5,Q96ST3,Q9BYW2,P17931,Q06124,Q5KU26,Q06481,O94992,P19474,P07437,Q8IXJ6,O43657,Q96PK6 33 +Regulation of establishment of protein localization to mitochondrion 0.3070913570626722 0.1625211302495947 0.8708954899396077 1.0 1.0 16 P30419,P55786,Q99496,Q13131,O14737 5 +Erythrocyte development 0.3525846702317279 0.162435992370385 0.87096252937648 1.0 1.0 7 P11413,P18074,P62753,O95696,Q6NYC1,Q9NYL9 6 +Positive regulation of defense response to virus by host 0.4629693225344104 0.1614145322871625 0.8717669216451847 1.0 1.0 4 Q96ST3 1 +Odontogenesis 0.3473066211490117 0.1614094434135208 0.8717709294283027 1.0 1.0 8 Q92769,Q6P4Q7 2 +Detoxification 0.277009088119736 0.1612157553149784 0.8719234724848584 1.0 1.0 28 P78417,P08183,P00374,P21266 4 +Negative regulation of execution phase of apoptosis 0.5014234875444749 0.1611295283612993 0.8719913838331688 1.0 1.0 2 O00273 1 +Gmp metabolic process 0.3067481678100698 0.1606341676728314 0.8723815424294836 1.0 1.0 14 O14936 1 +Regulation of hippo signaling 0.5282772071698674 0.159602884419576 0.8731939066732881 1.0 1.0 3 Q01085 1 +Neuron death in response to oxidative stress 0.340943474002549 0.1589148309520951 0.8737359757740695 1.0 1.0 9 Q9Y3I1,Q07820 2 +Negative regulation of fatty acid biosynthetic process 0.3969874635027609 0.158447475519751 0.8741042061815631 1.0 1.0 5 Q8WXW3,O75477 2 +Cellular aldehyde metabolic process 0.3017976327014812 0.1579740251164471 0.8744772666348852 1.0 1.0 19 P48735 1 +Transforming growth factor beta receptor signaling pathway 0.2887902258024671 0.1577915887977575 0.8746210267910954 1.0 1.0 22 Q15750,P62942,Q06481,Q92896 4 +Skeletal system development 0.2785621200303303 0.1575614802242025 0.8748023586735361 1.0 1.0 42 Q32P28,Q9BYW2,Q15904,O96028,O75844,Q06124 6 +Positive regulation of centriole replication 0.4992882562277466 0.1573806651931725 0.8749448505024895 1.0 1.0 2 P37198 1 +Female meiosis i 0.4989323843416369 0.1567618668778514 0.8754325270319909 1.0 1.0 2 Q15645 1 +Regulation of mitochondrial fission 0.3641820911927204 0.1561156051597117 0.8759418980413063 1.0 1.0 6 Q9NUQ9,P11233 2 +3 phosphoadenosine 5 phosphosulfate biosynthetic process 0.5260853267924365 0.1557912140622196 0.8761975962275468 1.0 1.0 3 Q8TB61 1 +Learning 0.3046438167899941 0.1555240084335354 0.8764082282213084 1.0 1.0 17 P50897,P42858 2 +Regulation of tau protein kinase activity 0.4975088967971417 0.1543038422825393 0.8773701678979164 1.0 1.0 2 P07900 1 +Positive regulation of tau protein kinase activity 0.4975088967971417 0.1543038422825393 0.8773701678979164 1.0 1.0 2 P07900 1 +Chromosome separation 0.2775702774605652 0.1537548046202663 0.877803070670715 1.0 1.0 33 Q9UJX4,O60566,P49454,P30153,O60216,Q9Y6A5,Q13042,Q9UJX3,Q9H1A4,Q9UJX2,O43670 11 +Positive regulation of ire1 mediated unfolded protein response 0.4967971530249011 0.1530851270182467 0.8783311445473103 1.0 1.0 2 P57088 1 +Regulation of perk mediated unfolded protein response 0.4967971530249011 0.1530851270182467 0.8783311445473103 1.0 1.0 2 P57088 1 +Positive regulation of endoplasmic reticulum unfolded protein response 0.4967971530249011 0.1530851270182467 0.8783311445473103 1.0 1.0 2 P57088 1 +Regulation of alpha beta t cell activation 0.3307228103739098 0.1525564571806728 0.8787480650865147 1.0 1.0 10 P04439 1 +Cellular extravasation 0.3942774890845862 0.1520336992457327 0.8791603564359391 1.0 1.0 5 Q9Y624 1 +Negative regulation of cell morphogenesis involved in differentiation 0.522249911000352 0.1492503098993151 0.8813561229606581 1.0 1.0 3 Q9P258,O43707 2 +Negative regulation of cell substrate junction organization 0.5222499110003498 0.1492503098993117 0.8813561229606608 1.0 1.0 3 Q9P258,P63167 2 +Regulated exocytosis 0.2761950899613776 0.1488169301354995 0.8816980910839822 1.0 1.0 30 Q06787,P09601,O95721,O14936,Q7L0J3 5 +Mitotic dna integrity checkpoint signaling 0.2822815366606524 0.1485339867459342 0.8819213658815419 1.0 1.0 23 Q9Y619,Q9NXR7 2 +Positive regulation of wound healing 0.3479761934909652 0.1485032275205443 0.8819456390053206 1.0 1.0 7 P04083 1 +Vasculature development 0.2615501322621908 0.1483172240799241 0.8820924228440741 1.0 1.0 84 Q9H2J4,P42785,P04083,Q96AY3,Q16539,Q07157,O95470,Q9NZ08,Q92990,Q13685,P46109,Q53EL6,O75179,Q9H6E4,Q96PU8,Q4VCS5,P09601,Q15750,Q9BYW2,O14964,Q02750,P04792,P35613,Q07954 24 +Interleukin 12 production 0.347829764652614 0.1480668960994481 0.8822899745162542 1.0 1.0 7 P01889,Q8WXW3 2 +Anterograde dendritic transport 0.4935943060498143 0.1476857699547545 0.8825907624102569 1.0 1.0 2 Q14254 1 +Activation of phospholipase d activity 0.520469918120324 0.1462705008891107 0.8837078522484652 1.0 1.0 3 P18085,P40616 2 +3 utr mediated mrna destabilization 0.3603156026764251 0.1456578193910495 0.8841915213923328 1.0 1.0 6 Q14103,Q92945 2 +Hepaticobiliary system development 0.2734814697046716 0.1446711304926971 0.8849705338485583 1.0 1.0 27 O75844,P04083,P09601,P11717 4 +Execution phase of apoptosis 0.3135785667910921 0.1413225023683193 0.887615173694106 1.0 1.0 12 Q8IXJ6,P63167,O95831,Q7L7X3 4 +Pyrimidine containing compound metabolic process 0.2942722388448382 0.1409290979266768 0.8879259547275233 1.0 1.0 20 Q9NRW3,Q9H773,P42345,P17812 4 +Positive regulation of oxidative stress induced cell death 0.3891294436747513 0.1401509783906895 0.8885407030971904 1.0 1.0 5 Q07820 1 +Regulation of canonical wnt signaling pathway 0.2747901182308518 0.1399858037718145 0.8886712068886489 1.0 1.0 30 Q16539,P50402,P62136,Q9UJX6,P40818,P52294,Q96K76,Q06330 8 +Pore complex assembly 0.3007090662008439 0.1366085055211528 0.8913402531028065 1.0 1.0 14 P57740,Q9BTX1,Q9NQC3 3 +T cell chemotaxis 0.5144179423282272 0.1364039417724779 0.8915019577211669 1.0 1.0 3 Q15149,Q9H4A3 2 +Lymphocyte chemotaxis 0.5144179423282272 0.1364039417724779 0.8915019577211669 1.0 1.0 3 Q15149,Q9H4A3 2 +Respiratory system process 0.3437324076136114 0.1360187420384429 0.8918064646573813 1.0 1.0 7 P10253 1 +Nuclear transcribed mrna poly a tail shortening 0.3561369882812256 0.1346418538816927 0.89289504827632 1.0 1.0 6 Q9UIV1,P11940 2 +Xenobiotic transport 0.4492340387086031 0.1345880543727566 0.8929375868973688 1.0 1.0 4 P08183 1 +Sprouting angiogenesis 0.3166041828362671 0.1339238201412633 0.8934628142106191 1.0 1.0 11 P09601 1 +Negative regulation of dna binding transcription factor activity 0.2794219496383611 0.13309879801678 0.8941152457336901 1.0 1.0 23 O76024,O75832,Q92769,P09601,P19474 5 +Cellular component disassembly involved in execution phase of apoptosis 0.3858211613822487 0.1327251924608883 0.8944107184257377 1.0 1.0 5 P11388,Q96JB5,O95831,O00273 4 +Positive regulation of ion transmembrane transport 0.2722646793400654 0.1322360266765177 0.8947976061531775 1.0 1.0 28 P78417,P08183,Q9Y4C2 3 +Changes to dna methylation involved in embryo development 0.482918149466188 0.1306865572006849 0.8960232669347514 1.0 1.0 2 P26358 1 +Regulation of genetic imprinting 0.4829181494661831 0.1306865572006776 0.8960232669347572 1.0 1.0 2 Q6PD62 1 +Endothelial cell development 0.2988386359935778 0.1300406286300477 0.8965342825883438 1.0 1.0 17 Q9Y624,Q07157,Q96S97,P21266 4 +Regulation of cellular response to heat 0.3539920637605052 0.1291040944323113 0.8972752822366983 1.0 1.0 6 Q99543 1 +Retina homeostasis 0.4461524926262712 0.1288976292360686 0.8974386526164346 1.0 1.0 4 Q15555,P04792 2 +Glycoprotein metabolic process 0.2717783707332766 0.1281416638975936 0.8980368647926291 1.0 1.0 48 Q7LGA3,O00462,Q86SF2,P04844,Q9Y287,P46977,Q92542,Q96IZ0,Q10472,O43505,O15118,O60502 12 +Superoxide metabolic process 0.3532716556060361 0.1272620727999129 0.8987329776995823 1.0 1.0 6 P00374 1 +Cell junction disassembly 0.4451056045703253 0.126991973731095 0.8989467511513325 1.0 1.0 4 Q15555 1 +Regulation of mitotic nuclear division 0.2734851222153386 0.1269137448101992 0.8990086678272584 1.0 1.0 33 O14744,Q9UJX4,O60566,P49454,O60216,Q13042,Q9UJX3,Q96DY7,Q9UJX2,O43670 10 +Positive regulation of release of cytochrome c from mitochondria 0.3530688381362605 0.1267451175048917 0.8991421351640303 1.0 1.0 6 O14737 1 +Membrane repolarization during action potential 0.382614891343059 0.125686891255442 0.8999797788358892 1.0 1.0 5 P62258,P21333,P54289,P05023 4 +Gtp biosynthetic process 0.4790035587188586 0.1248356933948282 0.9006536291680669 1.0 1.0 2 P15531 1 +Response to muramyl dipeptide 0.443677412127975 0.1244147854460068 0.9009868672101964 1.0 1.0 4 P08670 1 +Cellular response to vitamin d 0.4426638176638379 0.1226015490738017 0.9024226277164212 1.0 1.0 4 O15164,Q8TB36,P20020 3 +Eye photoreceptor cell differentiation 0.4425984513227289 0.1224850647298341 0.9025148735477632 1.0 1.0 4 P54802 1 +Cellular response to radiation 0.2738427051874563 0.1217700907544982 0.9030811017593658 1.0 1.0 40 Q16539,P30419,Q06787,Q15555,Q96KB5,P31751,Q96RU2,Q9NXR7,P62993,O75844,Q96K76 11 +Regulation of nuclear division 0.2723827552734718 0.1211854731519059 0.9035441300570302 1.0 1.0 35 O14744,Q9UJX4,O60566,P49454,O60216,Q8IXJ6,Q13042,Q9UJX3,Q96DY7,Q9UJX2,O43670 11 +Regulation of kidney development 0.4743772241992764 0.1181826703774177 0.9059229207567774 1.0 1.0 2 P80723 1 +Kidney mesenchyme development 0.4743772241992764 0.1181826703774177 0.9059229207567774 1.0 1.0 2 P80723 1 +Metanephric mesenchyme development 0.4743772241992764 0.1181826703774177 0.9059229207567774 1.0 1.0 2 P80723 1 +Regulation of epithelial cell differentiation involved in kidney development 0.4743772241992753 0.118182670377416 0.9059229207567788 1.0 1.0 2 P35222 1 +Nephron morphogenesis 0.4743772241992753 0.118182670377416 0.9059229207567788 1.0 1.0 2 P35222 1 +Mesenchymal to epithelial transition involved in metanephros morphogenesis 0.4743772241992753 0.118182670377416 0.9059229207567788 1.0 1.0 2 P35222 1 +Nephron tubule epithelial cell differentiation 0.4743772241992753 0.118182670377416 0.9059229207567788 1.0 1.0 2 P35222 1 +Cell differentiation involved in metanephros development 0.4743772241992753 0.118182670377416 0.9059229207567788 1.0 1.0 2 P35222 1 +Metanephric nephron development 0.4743772241992753 0.118182670377416 0.9059229207567788 1.0 1.0 2 P35222 1 +Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis 0.4743772241992753 0.118182670377416 0.9059229207567788 1.0 1.0 2 P35222 1 +Renal vesicle development 0.4743772241992753 0.118182670377416 0.9059229207567788 1.0 1.0 2 P35222 1 +Metanephric nephron morphogenesis 0.4743772241992753 0.118182670377416 0.9059229207567788 1.0 1.0 2 P35222 1 +Metanephric renal vesicle morphogenesis 0.4743772241992753 0.118182670377416 0.9059229207567788 1.0 1.0 2 P35222 1 +Positive regulation of mesenchymal cell proliferation 0.4743772241992753 0.118182670377416 0.9059229207567788 1.0 1.0 2 P35222 1 +Cellular response to brain derived neurotrophic factor stimulus 0.4740213523131594 0.1176825696207455 0.9063191782269224 1.0 1.0 2 Q05086 1 +Positive chemotaxis 0.3493190451276146 0.1173171559813337 0.906608730401425 1.0 1.0 6 P14174 1 +Positive regulation of intrinsic apoptotic signaling pathway 0.2962574880155325 0.1172182726328822 0.906687087271193 1.0 1.0 15 O60443 1 +Negative regulation of muscle hypertrophy 0.4394586894587038 0.1169542761745153 0.9068962870624644 1.0 1.0 4 P02545,O76003,P11413 3 +Positive regulation of peptidyl serine phosphorylation 0.3066038009171952 0.11597493992803 0.9076724027944032 1.0 1.0 12 P14174,P35080 2 +Cell motility involved in cerebral cortex radial glia guided migration 0.472597864768685 0.1156987599054133 0.9078912891049872 1.0 1.0 2 O94901 1 +Positive regulation of amyloid beta clearance 0.5006914968452082 0.1155410178906803 0.9080163105830894 1.0 1.0 3 Q07954 1 +Acid secretion 0.4383567497778136 0.1150430759019749 0.9084109790510356 1.0 1.0 4 Q7L0J3 1 +Inner mitochondrial membrane organization 0.2952373974649687 0.1147688887841983 0.9086283092251304 1.0 1.0 17 Q13505,Q9Y512 2 +Synaptic vesicle priming 0.4379891876336936 0.1144090343989873 0.9089135526080712 1.0 1.0 4 Q7L0J3 1 +Cytoplasmic translational initiation 0.2940857506014079 0.1142927141378448 0.90900575792944 1.0 1.0 18 P55010,Q9BWF3,P23588 3 +Negative regulation of cell death 0.2930048203721449 0.1138826363866366 0.9093308301648486 1.0 1.0 190 Q01105,P16989,P14174,Q15392,Q9Y3I1,P21796,P45880,P04083,O75312,Q07157,Q9UMX5,P27635,Q9BZZ5,Q14247,P46379,P30533,Q53EL6,O76024,O95881,P50897,P61289,P45985,Q9NY61,P49327,P09601,P16435,Q9NXR7,Q92905,O15118,P61978,Q9UNH7,P04062,Q96K76,Q96ST3,Q8IYB8,P17931,P78318,O75832,Q07820,P42858,P31751,Q92769,Q86XL3,P04792,Q96C86,P13051 46 +Regulation of cellular protein catabolic process 0.2628627972934015 0.1134247263868763 0.9096938373822864 1.0 1.0 78 O43765,Q9H2J4,Q06787,O75832,Q9H000,Q8IXJ6,Q92990,P46379,Q8NHS3,Q9UL46,P04062,Q96KB5,Q07954 13 +Positive regulation of lipid transport 0.347243772514016 0.1122058553544032 0.9106601865898408 1.0 1.0 6 P14174 1 +Positive regulation of reproductive process 0.3471932699986916 0.1120824208721628 0.9107580557024142 1.0 1.0 6 Q8IXJ6,Q92769 2 +Genitalia morphogenesis 0.4697508896797022 0.1118104956014738 0.9109736654238124 1.0 1.0 2 P35222 1 +Embryonic forelimb morphogenesis 0.4697508896797022 0.1118104956014738 0.9109736654238124 1.0 1.0 2 P35222 1 +Forelimb morphogenesis 0.4697508896797022 0.1118104956014738 0.9109736654238124 1.0 1.0 2 P35222 1 +Regulation of mitotic cell cycle 0.264533392799237 0.11046486135541 0.912040715861079 1.0 1.0 117 Q5VTR2,Q9Y3I1,O60216,Q9UKG1,P04083,Q9UJX2,Q13564,P18074,O75844,Q13042,P31350,O43670,O75179,P61289,Q9NXR7,Q9Y619,Q96ST3,Q96K76,Q9UJX3,Q96DY7,Q7L7X3,Q06124,Q9Y2S7,Q9UJX4,P21127,Q06481,Q9UL46,Q8IXJ6 28 +Response to dopamine 0.3178783224130601 0.1091244435765293 0.9131037874903823 1.0 1.0 10 Q92542,Q96ST3 2 +Retrograde transport endosome to golgi 0.2696104016722361 0.1082212862599829 0.9138201601254896 1.0 1.0 30 Q9Y5X3,Q13190,Q8IUD2,O15260,O75503,Q9UNH7,Q96JG6,Q93009 8 +Regulation of leukocyte apoptotic process 0.3247131453216118 0.106521129148922 0.91516889214361 1.0 1.0 9 P14174,P04083 2 +Regulation of dna demethylation 0.4938966458415392 0.1059880467101342 0.91559183610806 1.0 1.0 3 Q93009 1 +Inflammatory response to antigenic stimulus 0.3165980269473399 0.105002269810017 0.9163740076303636 1.0 1.0 10 Q9H000,Q16539,P28070 3 +Regulation of glucocorticoid metabolic process 0.4644128113878971 0.1048028321716413 0.916532262680195 1.0 1.0 2 P05023 1 +Positive regulation of stress activated protein kinase signaling cascade 0.3239779909020283 0.1042806786175267 0.9169466105376418 1.0 1.0 9 O15344,Q99873,Q7L7X3 3 +Positive regulation of extrinsic apoptotic signaling pathway 0.3238824727632898 0.1039904456192412 0.9171769307524588 1.0 1.0 9 P62136,P30154 2 +Regulation of ire1 mediated unfolded protein response 0.3721445165717282 0.1038010951131043 0.9173271973912054 1.0 1.0 5 Q92905 1 +Response to type i interferon 0.2924833936597633 0.1033752969161624 0.9176651172964388 1.0 1.0 17 Q16543,P34897,Q7Z739,Q9BYW2,Q9UIV1,Q06124 6 +Negative regulation of rig i signaling pathway 0.491278034887855 0.1024423945794514 0.9184055346473654 1.0 1.0 3 Q07021,Q92890 2 +Head development 0.2701191573464912 0.1009699299862437 0.9195743305515084 1.0 1.0 129 Q9NQC3,Q96N66,O75503,Q9UQB8,O95470,P46379,Q9Y6A5,Q06330,P46109,P50897,Q9H6E4,Q92542,O15027,P54802,P04062,Q9BYW2,Q96ST3,Q06124,Q14103,Q5KU26,Q02750,O94992,O95983,P62995,Q8IXJ6,P61421 26 +Negative regulation of dna damage response signal transduction by p53 class mediator 0.4298557535145387 0.1008215921314473 0.919692086134293 1.0 1.0 4 P14174 1 +Central nervous system development 0.2837288680106017 0.0998274745085141 0.9204812954935004 1.0 1.0 161 Q9NQC3,P15260,P08670,Q96N66,O75503,Q9UQB8,O75312,Q15022,P18074,P46379,P51648,Q9Y6A5,Q9H9T3,Q06330,P46109,P50897,Q9H6E4,Q92542,O15027,P54802,P04062,Q9BYW2,Q96ST3,Q06124,Q14103,O14773,Q92769,Q5KU26,Q86XL3,Q02750,Q06481,O94992,O95983,P62995,Q8IXJ6,Q07954,P61421,P42345 38 +Regulation of ubiquitin dependent protein catabolic process 0.2673136252386089 0.0992484249741107 0.9209410270550812 1.0 1.0 49 O43765,Q9H2J4,O75832,Q9H000,Q8IXJ6,Q92990,P46379,P04062,Q96KB5 9 +Regulation of synapse assembly 0.4287749287749341 0.0990797432934747 0.9210749554486376 1.0 1.0 4 Q9H2P0,Q04637,Q96HC4 3 +Chromosome attachment to the nuclear envelope 0.4594306049822081 0.098591011081202 0.9214630073658494 1.0 1.0 2 O94901 1 +Development of primary female sexual characteristics 0.3145715625036684 0.0985564292399024 0.9214904659540072 1.0 1.0 10 O75874 1 +Regulation of nuclear transcribed mrna poly a tail shortening 0.4276562415087598 0.0972926087690421 0.9224940255030288 1.0 1.0 4 P11940 1 +Activation of innate immune response 0.2909400862985028 0.0971004235730749 0.9226466444899492 1.0 1.0 17 Q9NUD5,Q96ST3,Q96PK6,O94992 4 +Response to hyperoxia 0.4270932897995962 0.0963993281101436 0.923203425730361 1.0 1.0 4 Q92769 1 +Positive regulation of phosphorus metabolic process 0.2596019238931952 0.0921218478065396 0.926601230219865 1.0 1.0 111 Q13432,P51116,P14174,Q9BZF1,Q92990,Q92797,P51114,P46109,Q8WXW3,Q15750,P04062,Q13501,Q9H223,Q7L7X3,Q06124,Q06787,O75832,Q92769,P31751,Q86XL3,Q02750,P35080,Q9H7B4 23 +Rna splicing via endonucleolytic cleavage and ligation 0.3660801300923021 0.0919014377604626 0.9267763491303208 1.0 1.0 5 Q5KU26 1 +Genomic imprinting 0.4830900676397298 0.0918392763410654 0.926825737902094 1.0 1.0 3 P49711,Q6PD62 2 +Monocyte chemotaxis 0.3385894537558518 0.0917190820527715 0.9269212360105464 1.0 1.0 6 P04083 1 +Negative regulation of cell cycle g1 s phase transition 0.2995694761566451 0.0917096645114191 0.9269287185851852 1.0 1.0 12 P78527,P24941,Q9Y3I1,Q7Z7L1,Q6IQ49,Q8N6R0,O96017 7 +Atp synthesis coupled electron transport 0.2673374415602318 0.0882480557121518 0.929679523338326 1.0 1.0 35 O75306,P47985,O43676 3 +Negative regulation of guanyl nucleotide exchange factor activity 0.479886080455676 0.0878880088803527 0.9299656872499336 1.0 1.0 3 Q9NWH9,P16949 2 +Regulation of leukocyte migration 0.2864391571419044 0.087581364905235 0.930209413907212 1.0 1.0 19 P14174,P46109,P04083,P09601 4 +Regulation of bicellular tight junction assembly 0.3634628888954515 0.0869428948778369 0.9307169034082046 1.0 1.0 5 Q9Y624 1 +Positive regulation of transcription by rna polymerase iii 0.317873706742786 0.0861374723855952 0.9313571356534096 1.0 1.0 9 Q9Y2F5,Q9NR30,O60264,P35659,Q9BQG0,O75533,Q9NY93,P42345 8 +Endoplasmic reticulum to golgi vesicle mediated transport 0.259963927333057 0.0831639522599811 0.9337211753428448 1.0 1.0 57 P55735,Q92734,Q96RQ1,Q9Y282,Q969M3,Q9P2W9,Q96PC5,O15027,Q15437,Q12907 10 +Positive regulation of erbb signaling pathway 0.3611314059875699 0.0826158254253403 0.934157017423902 1.0 1.0 5 Q9NQC3 1 +Organic cyclic compound catabolic process 0.2831041655472202 0.0824704853617341 0.9342725876337852 1.0 1.0 163 Q9NRW3,Q9H074,Q5RKV6,Q96B26,P16989,P51116,P08670,Q13310,Q13126,P35637,P21964,Q08J23,O75312,Q9NRN7,Q9C0B1,P30519,Q9BRP8,Q8WTV0,O00584,Q969T7,Q92945,Q86VM9,P51114,Q92804,O60506,Q12972,Q9H773,P09601,Q6PGP7,Q99729,Q14011,Q14103,P67809,Q06787,P98175,Q96C86 36 +Regulation of telomere capping 0.3342836778332079 0.0820297150464322 0.9346230838856068 1.0 1.0 6 Q14103,Q92889,P28482,P18887,Q93009 5 +Plasma membrane raft assembly 0.444483985765127 0.0818051447543307 0.9348016648670534 1.0 1.0 2 O75955 1 +Plasma membrane raft organization 0.444483985765127 0.0818051447543307 0.9348016648670534 1.0 1.0 2 O75955 1 +Mesenchymal to epithelial transition 0.4745461018155883 0.0815468532887355 0.9350070653849862 1.0 1.0 3 P80723,P35222 2 +Metanephros morphogenesis 0.4745461018155883 0.0815468532887355 0.9350070653849862 1.0 1.0 3 P80723,P35222 2 +Intermediate filament organization 0.3598317210132128 0.0802405694233524 0.9360459244338156 1.0 1.0 5 P08670 1 +Female sex differentiation 0.3007160509288444 0.0800962688792237 0.9361606902183536 1.0 1.0 11 O75874 1 +Positive regulation of blood vessel endothelial cell migration 0.3084974334275571 0.0798220486402786 0.9363787879965346 1.0 1.0 10 P04083,P04792,P09601 3 +Vitamin d receptor signaling pathway 0.442348754448398 0.0796270334877504 0.936533893864884 1.0 1.0 2 O15164 1 +Regulation of vitamin d receptor signaling pathway 0.442348754448398 0.0796270334877504 0.936533893864884 1.0 1.0 2 O15164 1 +Positive regulation of cell substrate junction organization 0.3154909805607682 0.0792810907992402 0.9368090463099032 1.0 1.0 9 Q9Y2S7,Q15555 2 +Positive regulation of response to biotic stimulus 0.2646697285030328 0.0791360871305356 0.9369243801280208 1.0 1.0 30 O75179,P14174,Q9NUD5,O94992,Q14671,Q96ST3,Q96PK6 7 +Methylation 0.2471375261820829 0.0782370230961479 0.9376395120895928 1.0 1.0 93 Q8N6R0,Q8N2A8,Q9BYW2,Q99873,Q96ST2,Q9H993,O60725,Q8NB78,P21964,O95983,O96028,Q08J23,Q9H7B4,Q86X55,Q03164,O75844,Q9BV86 17 +Muscle organ morphogenesis 0.3586939109892309 0.0781828202159513 0.9376826276644964 1.0 1.0 5 Q06330,P62942 2 +Cardiac muscle tissue morphogenesis 0.3586939109892309 0.0781828202159513 0.9376826276644964 1.0 1.0 5 Q06330,P62942 2 +Ventricular cardiac muscle tissue morphogenesis 0.3586939109892309 0.0781828202159513 0.9376826276644964 1.0 1.0 5 Q06330,P62942 2 +Cardiac ventricle morphogenesis 0.3586939109892309 0.0781828202159513 0.9376826276644964 1.0 1.0 5 Q06330,P62942 2 +Mesenchyme development 0.2649886417336582 0.0777308039740821 0.9380421902020776 1.0 1.0 31 Q9NQC3,Q92769,P17844,Q9UK61,Q92841,Q99729,Q06330,Q53EL6,P42345 9 +Regulation of stress granule assembly 0.4706952595855088 0.07716159601366 0.9384949924667624 1.0 1.0 3 Q13131 1 +Response to l phenylalanine derivative 0.4391459074733075 0.0764597822315209 0.9390533094029848 1.0 1.0 2 P48507 1 +Response to thyroxine 0.4391459074733075 0.0764597822315209 0.9390533094029848 1.0 1.0 2 P48507 1 +Regulation of body fluid levels 0.267312393779535 0.0763056888221915 0.9391759000163952 1.0 1.0 41 O76024,Q16539,Q9Y3B8,P38435,P12814,Q13505,P04792,Q13310,P04062,Q9Y624 10 +Regulation of cellular amide metabolic process 0.2861646853859536 0.0762497228993435 0.9392204246450042 1.0 1.0 174 Q9H074,Q9NQC3,P15260,Q96B26,P16989,P51116,P62136,P42345,P08670,Q10713,O95197,P23588,Q567V2,Q9Y6M1,Q9C0B1,Q9BRP8,P11940,Q969T7,P27635,Q92945,Q14671,P31483,P51114,Q07666,O60506,Q96PU8,Q92615,P55010,O15514,Q71RC2,Q9Y2L1,Q9HCE1,Q9BPZ3,Q9BWF3,Q14011,Q14103,P34897,P67809,Q7L576,Q06787,P31751,P04792,Q96PZ0,P00374,P98179,Q96C86,Q9Y2R0 47 +Positive regulation of osteoblast differentiation 0.4688501245994979 0.075115537622119 0.9401227855157994 1.0 1.0 3 O00299,P35222 2 +Transcytosis 0.3139972750644242 0.0750482672467947 0.9401763084346836 1.0 1.0 9 Q07954,P55899 2 +Negative regulation of cd4 positive alpha beta t cell activation 0.412496894508048 0.0746462657257489 0.9404961620555404 1.0 1.0 4 P04083 1 +Regulation of cd4 positive alpha beta t cell activation 0.412496894508048 0.0746462657257489 0.9404961620555404 1.0 1.0 4 P04083 1 +Mrna pseudouridine synthesis 0.4676213632357175 0.0737726551421019 0.9411912857543454 1.0 1.0 3 Q96PZ0 1 +Cell fate commitment involved in formation of primary germ layer 0.4113247863247918 0.0730163852428548 0.94179307877574 1.0 1.0 4 P35222,Q6PD62,Q8N7H5 3 +Endodermal cell fate commitment 0.4113247863247918 0.0730163852428548 0.94179307877574 1.0 1.0 4 P35222,Q6PD62,Q8N7H5 3 +Positive regulation of actin filament bundle assembly 0.3061875578755068 0.072931757265934 0.9418604225828604 1.0 1.0 10 P07737,P35080 2 +Response to vitamin a 0.4345195729537346 0.0720929738470674 0.942527917735152 1.0 1.0 2 P04818 1 +Response to insecticide 0.4345195729537344 0.0720929738470671 0.9425279177351522 1.0 1.0 2 P36551 1 +Positive regulation of apoptotic signaling pathway 0.2607414166356558 0.0719389637362624 0.9426504817852552 1.0 1.0 27 O00429,Q07820,P62136,P30153,P49327,O60443,P30154 7 +Positive regulation of carbohydrate metabolic process 0.3291830121815792 0.0709889720422902 0.9434065323828382 1.0 1.0 6 Q16531,P31751 2 +Ubiquitin independent protein catabolic process via the multivesicular body sorting pathway 0.4088319088319028 0.0696071848107554 0.9445063181622496 1.0 1.0 4 O75351,Q9UN37,Q8WUM4 3 +Dephosphorylation of rna polymerase ii c terminal domain 0.4316725978647697 0.0695256251113278 0.94457123611227 1.0 1.0 2 Q9NQG5 1 +Actomyosin contractile ring organization 0.3534022087637984 0.0688784501581226 0.945086372055742 1.0 1.0 5 Q9UN37,Q15149,Q8WUM4,Q9H0H5 4 +Response to abiotic stimulus 0.2890548530500885 0.0686817887155807 0.9452429144679626 1.0 1.0 187 P30536,P16989,Q13432,P62136,P04083,P30519,O60884,Q96A26,Q9Y487,O75844,Q8N511,Q15555,P45985,P09601,Q9NXR7,P08183,P04062,Q96K76,Q99543,Q9BWF3,Q14011,Q14103,P30419,Q06787,P42858,P31751,Q06481,Q15904,O75306,Q9Y624,Q96RU2 31 +Regulation of dopamine receptor signaling pathway 0.4284697508896791 0.0667443674751153 0.9467852129006612 1.0 1.0 2 O14744 1 +Positive regulation of dopamine receptor signaling pathway 0.4284697508896791 0.0667443674751153 0.9467852129006612 1.0 1.0 2 O14744 1 +Regulation of presynapse organization 0.4284697508896791 0.0667443674751153 0.9467852129006612 1.0 1.0 2 Q04637 1 +Terminal button organization 0.4284697508896791 0.0667443674751153 0.9467852129006612 1.0 1.0 2 O95295 1 +Regulation of protein deacetylation 0.282452030473392 0.0665208203972003 0.9469631821404724 1.0 1.0 15 Q9ULX6,O43823 2 +Negative regulation of synaptic transmission 0.3267997148966423 0.0659935591224431 0.9473829533532758 1.0 1.0 6 Q9H2P0,Q06787,P38919,P21359,Q8NBU5 5 +Multi organism reproductive process 0.2697377557126321 0.0657567748285582 0.947571470402673 1.0 1.0 134 P16989,O75718,P45880,Q08J23,Q9UIQ6,Q9BQE5,P07858,Q9P0K7,Q8N2A8,P46379,Q99417,Q14671,O60684,P46109,Q07666,Q8NI77,Q96PU8,P11717,Q15067,Q4G0J3,Q9BPZ3,Q9BW83,P46926,Q9BTX1,Q92769,Q8NB78,P30153,P35613,Q8IXJ6,Q01085 30 +Activation of gtpase activity 0.2825137684793115 0.0645069469474915 0.9485665757701988 1.0 1.0 16 Q66K14,P46109,P31751 3 +Keratinocyte development 0.4049145299145335 0.0644065604850852 0.9486465063633074 1.0 1.0 4 Q15149,Q8WX93,Q9Y3B8 3 +Negative regulation of double strand break repair via nonhomologous end joining 0.4256227758007123 0.0643655726857925 0.9486791421784292 1.0 1.0 2 P52926 1 +Positive regulation of blood pressure 0.4581701673193279 0.0639626648332602 0.9489999550522612 1.0 1.0 3 Q9H4A3,P09493 2 +Embryonic morphogenesis 0.2587975674710669 0.0610693037124158 0.951304015594948 1.0 1.0 60 P67809,Q9BYW2,P11233,Q92769,Q9UK61,Q4VCS5,Q92990,P54802,P10644,P07737,P42892,Q96S97,Q9BVC5 13 +Ventricular septum development 0.3111554151234446 0.0577869502832244 0.9539183329739382 1.0 1.0 8 O96028,P43243 2 +3 phosphoadenosine 5 phosphosulfate metabolic process 0.346648267471476 0.0576373165500148 0.954037524758494 1.0 1.0 5 Q8TB61 1 +Hormone transport 0.2600805154945073 0.0575775775417878 0.9540851105657264 1.0 1.0 29 Q01650,Q16836,P04083,P53985,Q06124 5 +Synapse organization 0.2591934203704926 0.0573585911552423 0.9542595481371934 1.0 1.0 52 Q16539,Q7L576,P18085,O95295,P12814,Q9UJX6,P61160,Q14247,Q12955,Q8IUD2,P35080,Q14444,P07737,Q9UQB8,P07437,P46109,O00264,P10586 18 +Blood vessel morphogenesis 0.259873295861119 0.0566541344334933 0.95482071071432 1.0 1.0 69 Q9H2J4,P42785,P04083,Q96AY3,Q16539,Q07157,Q9NZ08,Q92990,O95470,Q13685,Q9H6E4,Q96PU8,Q4VCS5,P09601,Q9BYW2,O14964,P04792,P35613,Q07954 19 +Protein localization to cell cortex 0.3455646597791153 0.0558997741953944 0.9554216507162788 1.0 1.0 5 Q14980,O43491,P53350,P11171 4 +Inositol lipid mediated signaling 0.2776696375743206 0.0549125452778162 0.95620813727381 1.0 1.0 14 Q8IXJ6,Q53EZ4,P42356 3 +Regulation of cell cycle g2 m phase transition 0.2609607421941977 0.0545756617937055 0.9564765289280948 1.0 1.0 31 Q13564,P49454,P11802,P52926,O60216,Q9NXR7,Q9Y619,P49959,Q96ST3,Q96K76,Q9UN37,Q7L7X3 12 +Protein maturation by iron sulfur cluster transfer 0.3945868945868989 0.051602417581212 0.9588454929572504 1.0 1.0 4 O76003,Q9H3K6,Q86SX6 3 +Protein localization to nucleus 0.253175877149268 0.0515206351109707 0.9589106592447284 1.0 1.0 106 O00505,P55735,Q9BW27,Q96ST3,Q99567,Q92973,O00629,P52294,Q9BZF1,Q4G0J3,Q06481,Q9UKG1,O75312,Q8NFQ8,O60684,P57740,Q13501,Q9NW64 18 +Regulation of actin filament bundle assembly 0.2741904892335599 0.0503361457423908 0.9598545201287658 1.0 1.0 20 P09493,Q07157,P63167,P35080,P07737,Q9Y624,P42345 7 +Cell volume homeostasis 0.3931623931623912 0.0499380978872132 0.960171717439782 1.0 1.0 4 P54105,P51790,P55011 3 +Negative regulation of protein serine threonine kinase activity 0.2782288993898918 0.0497396978512198 0.9603298212848052 1.0 1.0 18 Q9Y3I1,Q53EL6,P04062,O94992 4 +Definitive hemopoiesis 0.4421502313990751 0.0493642612177982 0.9606290088384888 1.0 1.0 3 Q96JB5,P55265 2 +Regulation of cardiac conduction 0.3924501424501464 0.049115077184172 0.960827588053106 1.0 1.0 4 P17612,P16615,P20020 3 +Adenylate cyclase inhibiting dopamine receptor signaling pathway 0.4039145907473323 0.0489458214875127 0.960962472332769 1.0 1.0 2 O14744 1 +Atrial cardiac muscle cell to av node cell signaling 0.403914590747331 0.0489458214875121 0.9609624723327694 1.0 1.0 2 O75694 1 +Dna replication synthesis of rna primer 0.4410822356710634 0.0484784562208284 0.9613349336960204 1.0 1.0 3 P49642,P49643 2 +Indole containing compound metabolic process 0.4007117437722439 0.0470504695390357 0.9624730031643028 1.0 1.0 2 Q92947 1 +Protein insertion into mitochondrial inner membrane 0.4393022427910329 0.0470256752127625 0.962492764300784 1.0 1.0 3 Q53H12,Q9P0J0 2 +Physiological cardiac muscle hypertrophy 0.4393022427910305 0.0470256752127602 0.9624927643007856 1.0 1.0 3 P11413,Q96HC4 2 +Glycerophospholipid biosynthetic process 0.2598795107840388 0.0456550179592095 0.963585216864713 1.0 1.0 32 Q9Y217,Q8NF37,Q9NPH0,Q99943,P42356,P35790 6 +Regulation of steroid hormone biosynthetic process 0.4375222499109903 0.0456021107473855 0.9636273867911468 1.0 1.0 3 P16435,P05023 2 +Regulation of hormone biosynthetic process 0.4375222499109903 0.0456021107473855 0.9636273867911468 1.0 1.0 3 P16435,P05023 2 +Positive regulation of dna dependent dna replication 0.388532763532768 0.0446966533596322 0.96434910126621 1.0 1.0 4 O95785,Q04837,P24941 3 +Replication fork processing 0.338083363021014 0.0443984414633386 0.9645868039575858 1.0 1.0 5 P12004,Q96FV9,P49959,Q9Y3Z3 4 +Female meiosis chromosome segregation 0.395729537366548 0.0442806305423521 0.9646807111166184 1.0 1.0 2 Q15003 1 +Regulation of anaphase promoting complex dependent catabolic process 0.3957295373665483 0.0442806305423521 0.9646807111166184 1.0 1.0 2 P24941 1 +Negative regulation of cell volume 0.3928825622775804 0.0427921940155541 0.9658671865645104 1.0 1.0 2 P51790 1 +Neutrophil differentiation 0.3866914416534878 0.042682608037297 0.9659545437098817 1.0 1.0 4 Q14739 1 +Rna interference 0.3064584013252162 0.0414697481744496 0.9669214095587813 1.0 1.0 7 Q5KU26,O94992 2 +Protein localization to chromosome telomeric region 0.2749166908527414 0.0414508810363581 0.9669364504241084 1.0 1.0 15 O14773 1 +Snrna processing 0.294852516872723 0.0410305240740168 0.9672715616528718 1.0 1.0 10 Q96B26 1 +Negative regulation of cell cell adhesion 0.2645423840147334 0.0400467411588112 0.9680558621035262 1.0 1.0 22 Q96IZ0,Q92990,P04083,Q96S97,P17931 5 +Presynapse organization 0.4286222855108627 0.0389127719198236 0.9689599337625469 1.0 1.0 3 O95295,Q04637 2 +Dendritic spine maintenance 0.4286222855108577 0.0389127719198199 0.9689599337625496 1.0 1.0 3 Q14247,P08069 2 +Ether biosynthetic process 0.3339878457805302 0.0384657012355449 0.969316377683505 1.0 1.0 5 O00116 1 +Regulation of dna topoisomerase atp hydrolyzing activity 0.4279102883588523 0.0384078143050473 0.9693625306661726 1.0 1.0 3 Q08211,Q00839 2 +Regulation of isomerase activity 0.4279102883588523 0.0384078143050473 0.9693625306661726 1.0 1.0 3 Q08211,Q00839 2 +Membrane repolarization during cardiac muscle cell action potential 0.3824786324786415 0.0382238099027705 0.9695092372080836 1.0 1.0 4 P62258,P21333,P05023 3 +Relaxation of muscle 0.3824786324786337 0.0382238099027624 0.96950923720809 1.0 1.0 4 P30626,P28161,P05023 3 +Cell communication by electrical coupling involved in cardiac conduction 0.3824786324786343 0.0382238099027624 0.96950923720809 1.0 1.0 4 P30626,P17612,P05023 3 +B cell lineage commitment 0.3829181494661972 0.0380928155131889 0.9696136795443342 1.0 1.0 2 P78527 1 +Replicative senescence 0.3829181494661949 0.0380928155131878 0.9696136795443352 1.0 1.0 2 O96017 1 +Negative regulation of mitophagy 0.3829181494661871 0.0380928155131845 0.9696136795443376 1.0 1.0 2 Q9NQ88 1 +2fe 2s cluster assembly 0.4268422926308285 0.0376585873054642 0.96995989510033 1.0 1.0 3 O76003,Q86SX6 2 +Negative regulation of gene expression 0.2924658392255779 0.036955593664625 0.9705204126559144 1.0 1.0 249 P30536,Q99829,Q9H074,Q5RKV6,Q96B26,P16989,P51116,Q9UK61,P14174,Q13363,P08670,Q10713,P38159,Q13310,P35637,P04083,P10644,Q9Y6M1,P22626,Q9C0B1,Q9BRP8,Q16539,Q01650,P11940,Q969T7,Q96FV9,O43823,Q92945,Q13242,Q14671,P31483,O75844,P51114,Q8IWR0,P46109,Q53EL6,Q92804,O60506,Q8WXW3,Q9NVV4,Q92615,P20073,P09601,O15514,P61978,Q9Y2L1,Q6PGP7,Q96S97,P04062,Q9HCE1,Q99729,Q9BPZ3,Q9BWF3,Q96ST3,Q8IYB8,Q14011,Q92896,Q14103,P34897,P67809,Q06787,P98175,Q6PKG0,Q5KU26,Q96IZ0,Q9UJX6,Q02750,Q06481,O94992,O95983,Q96PZ0,P00374,Q8IXJ6,Q07954,Q01085,Q96C86 76 +Positive regulation of cell cell adhesion mediated by cadherin 0.4253118352929008 0.0366019878692162 0.970802358503536 1.0 1.0 3 Q07157 1 +Regulation of ligase activity 0.380698005698007 0.0364009998234451 0.970962616965418 1.0 1.0 4 Q13155,P48507,Q9UBB9 3 +Regulation of translational initiation 0.2611137660393844 0.0352423895726329 0.9718864612190856 1.0 1.0 43 Q9H074,Q06787,P62136,P04792,P55010,O15514,P23588,Q9BPZ3,Q9BWF3,Q07666,P42345 11 +Mitochondrial electron transport ubiquinol to cytochrome c 0.3310076019367802 0.0343085730825827 0.9726310885643066 1.0 1.0 5 P47985,O14949 2 +Regulation of high voltage gated calcium channel activity 0.420078319686722 0.0331381916066082 0.9735643869655712 1.0 1.0 3 P54289,P30626 2 +Regulation by virus of viral protein levels in host cell 0.3294114941673568 0.0321372055919649 0.9743626329521426 1.0 1.0 5 Q9P035,Q16531 2 +Glutamate secretion 0.3654804270462671 0.031586381068299 0.9748019043047388 1.0 1.0 2 Q15042 1 +Glutamate secretion neurotransmission 0.3654804270462671 0.031586381068299 0.9748019043047388 1.0 1.0 2 Q15042 1 +Positive regulation of natural killer cell mediated immunity 0.3633451957295335 0.030923621006355 0.9753304520903708 1.0 1.0 2 P11279 1 +Positive regulation of natural killer cell activation 0.3633451957295335 0.030923621006355 0.9753304520903708 1.0 1.0 2 P11279 1 +Positive regulation of natural killer cell mediated cytotoxicity 0.3633451957295335 0.030923621006355 0.9753304520903708 1.0 1.0 2 P11279 1 +Multicellular organismal homeostasis 0.2559122735349347 0.0305126103754338 0.975658236439228 1.0 1.0 62 Q9Y3B8,P49748,P42785,Q9UIQ6,Q9C0B1,Q9UBB6,Q07157,P02786,Q8NF37,P51790,Q06330,O76024,Q15555,P04062,Q13501,Q06124,O14773,Q16836,P04792,Q06481,Q9Y624,P23786 22 +Regulation of lipid kinase activity 0.414738341046639 0.0298358184219314 0.9761979925041484 1.0 1.0 3 Q05639,P60953 2 +Positive regulation of lipid kinase activity 0.414738341046639 0.0298358184219314 0.9761979925041484 1.0 1.0 3 Q05639,P60953 2 +Activation of cysteine type endopeptidase activity involved in apoptotic process 0.2792571437498631 0.0293467023535664 0.9765880798336984 1.0 1.0 12 Q96A26,O95831,Q92688,Q9NR28 4 +Positive regulation of b cell proliferation 0.4132499709366842 0.0289559631554467 0.9768997121644531 1.0 1.0 3 P14174 1 +Negative regulation of g protein coupled receptor signaling pathway 0.3266832917705674 0.0285140123827911 0.977252192308336 1.0 1.0 5 Q9NWH9,P31946,P50570,P16949 4 +Negative regulation of alpha beta t cell activation 0.3265990985736116 0.0284039638392493 0.977339962791653 1.0 1.0 5 P04083 1 +Negative regulation of hemopoiesis 0.2960597098818591 0.0282334846586767 0.9774759309668248 1.0 1.0 9 P04083 1 +Negative regulation of microtubule polymerization 0.3260804299810329 0.0277283364097689 0.9778788232019068 1.0 1.0 5 Q14155,Q15691 2 +Nonribosomal peptide biosynthetic process 0.4101103595585651 0.0271566163236327 0.9783348180907132 1.0 1.0 3 P48637,P48507 2 +Histone h3 deacetylation 0.3058031460811814 0.0264996238088782 0.9788588336518584 1.0 1.0 6 Q92769 1 +Regulation of protein modification by small protein conjugation or removal 0.256394704773825 0.0260413908892174 0.9792243244789096 1.0 1.0 70 P30536,Q9NVN8,Q96FW1,O75832,Q92990,Q96GG9,P62942,P19474,Q96DY7 9 +Pyrimidine deoxyribonucleoside monophosphate metabolic process 0.3437722419928896 0.0259981103366284 0.979258845675724 1.0 1.0 2 P04818 1 +Pyrimidine deoxyribonucleoside monophosphate biosynthetic process 0.3437722419928896 0.0259981103366284 0.979258845675724 1.0 1.0 2 P04818 1 +Dtmp metabolic process 0.3437722419928896 0.0259981103366284 0.979258845675724 1.0 1.0 2 P04818 1 +Regulation of mitotic recombination 0.4073239453530507 0.0256228782199776 0.9795581378784756 1.0 1.0 3 P18074 1 +Negative regulation of alpha beta t cell proliferation 0.3345195729537427 0.0242919541359402 0.9806197309082956 1.0 1.0 2 P78540 1 +Cytoplasmic translational elongation 0.4047867244478414 0.024276874568665 0.9806317591149712 1.0 1.0 3 P49588 1 +Telomerase holoenzyme complex assembly 0.4044143823424723 0.0240833410918848 0.9807861313522588 1.0 1.0 3 P07900,P08238 2 +Cell cell signaling involved in cardiac conduction 0.4040583837664682 0.0238992503642995 0.9809329722357928 1.0 1.0 3 P54289,O75694 2 +Blood vessel remodeling 0.4040583837664673 0.0238992503642992 0.9809329722357928 1.0 1.0 3 Q9P2D1,Q06330 2 +Cardiac chamber morphogenesis 0.2935459990455593 0.0222744374131606 0.9822290398116004 1.0 1.0 9 O96028 1 +Regulation of actin filament length 0.2576686389680545 0.0218263791887457 0.9825864516471684 1.0 1.0 37 Q9NUQ9,Q14247,P35080,Q96S97,P07737,P62993,Q9UQB8,P42345 8 +Regulation of cell morphogenesis involved in differentiation 0.2509721334968022 0.0216081254455644 0.9827605518777698 1.0 1.0 27 P07237,Q9UJX6,Q14155,P61160,O43707,Q9UQB8,Q14444,Q07021,Q96S97,P46109 10 +Pro b cell differentiation 0.3128113879003621 0.0214833625135157 0.9828600751919554 1.0 1.0 2 P78527 1 +Lymphoid progenitor cell differentiation 0.3128113879003621 0.0214833625135157 0.9828600751919554 1.0 1.0 2 P78527 1 +Muscle cell differentiation 0.2518661789754524 0.0214025498683901 0.982924539531734 1.0 1.0 56 Q16539,P67809,O75179,Q9BYT8,Q96PU8,Q8IV08,Q92990,Q99523,P10644,Q9H7B4,O75844,Q9BWF3,Q53EL6,P42345 14 +Cell cycle checkpoint signaling 0.2552132303791742 0.0201686594435207 0.9839088289391976 1.0 1.0 51 Q16539,Q7L7X3,Q13564,Q96RU2,Q96FV9,Q12888,Q9NXR7,Q9Y619,Q08J23,Q06124 10 +Vesicle cytoskeletal trafficking 0.269993822837644 0.0201013103748803 0.9839625548294252 1.0 1.0 17 Q92572,P42858 2 +Negative regulation of ire1 mediated unfolded protein response 0.2925266903914686 0.0199648293099274 0.9840714291147908 1.0 1.0 2 Q96HY6 1 +Positive regulation of ubiquitin protein ligase activity 0.3958704165183402 0.0199146708282857 0.9841114418376892 1.0 1.0 3 P63208,Q16763 2 +Epithelial cell maturation 0.289323843416376 0.0197957022843144 0.9842063462932278 1.0 1.0 2 P04818 1 +Alpha linolenic acid metabolic process 0.2882562277580131 0.0197428524834389 0.98424850609404 1.0 1.0 2 O14734 1 +Vesicle tethering to golgi 0.2790035587188699 0.0193510627289156 0.9845610493737292 1.0 1.0 2 Q9BZH6 1 +Bile acid secretion 0.2711743772242089 0.0190992874938884 0.9847618998246874 1.0 1.0 2 Q13131 1 +Epithelium development 0.2677394745645525 0.0183855316805801 0.9853312945395472 1.0 1.0 138 Q9NQC3,P62136,P08670,P21796,O60869,P04083,Q08J23,P07737,P62993,O00471,P09960,P07858,Q07157,P11233,P18074,Q92990,P21266,O75844,Q06330,Q15417,P58107,P49327,P42892,Q96S97,Q9BYW2,P17931,O14773,P07602,Q92769,P31751,Q02750,P31942,P07437,Q9Y624,P42345 35 +Centrosome separation 0.3596866096866106 0.01755370052678 0.9859948926063158 1.0 1.0 4 P37198,P52732,Q9UNZ2 3 +Positive regulation of protein acetylation 0.285470740670152 0.0170731745748708 0.9863782393813364 1.0 1.0 10 Q7L7X3 1 +Copii coated vesicle budding 0.2656874457528698 0.0167408205829292 0.9866433816013028 1.0 1.0 20 P55735,Q92734,O15027,Q15437 4 +Regulation of exocytosis 0.2572885857182189 0.0167043005363849 0.9866725163086404 1.0 1.0 38 Q06787,Q92783,O14964,P35080,P09601,P04083,O14936 7 +Regulation of dna duplex unwinding 0.3579059829059859 0.0161726249827613 0.9870966747066764 1.0 1.0 4 P49736,P11388,Q04837 3 +Mammary gland development 0.2687497883518129 0.0160226387945313 0.9872163308660076 1.0 1.0 17 Q9NQC3,P31751 2 +Striated muscle cell differentiation 0.257115539918593 0.0156727151628593 0.9874954944697424 1.0 1.0 38 Q16539,P67809,P42345,Q8IV08,Q99523,P10644,Q9H7B4,O75844,Q9BYT8 9 +Positive regulation of small molecule metabolic process 0.2692537159746924 0.0148232627677479 0.9881731806145768 1.0 1.0 13 P16435,P04083,Q16531,P31751 4 +Cellular response to starvation 0.2481423611376763 0.0147223298692313 0.9882537046288672 1.0 1.0 26 P21964,P04062 2 +Phospholipid biosynthetic process 0.2578275446827185 0.0144672747463317 0.9884571875001112 1.0 1.0 44 Q9Y217,Q8NF37,O75874,O15270,Q9NPH0,Q99943,P42356,P35790 8 +Endoplasmic reticulum to cytosol transport 0.2779109045983538 0.014466572862494 0.9884577474637876 1.0 1.0 11 Q9Y679 1 +Protein localization to membrane raft 0.3823424706301201 0.0143138747971242 0.988579570278394 1.0 1.0 3 O75955,Q14254 2 +Relaxation of cardiac muscle 0.3823424706301186 0.0143138747971237 0.9885795702783944 1.0 1.0 3 P28161,P05023 2 +Positive regulation of ligase activity 0.3805624777500946 0.0136615592902706 0.9890999918265098 1.0 1.0 3 P48507,Q13155 2 +Voluntary musculoskeletal movement 0.3805624777500901 0.0136615592902689 0.9890999918265112 1.0 1.0 3 P42345,Q96QK1 2 +Synaptic vesicle transport 0.277368859573195 0.0130800033906258 0.9895639648176549 1.0 1.0 11 Q92572 1 +Positive regulation of response to wounding 0.2891597606696933 0.0122341070699913 0.9902388383519214 1.0 1.0 9 P04083 1 +Vascular associated smooth muscle cell migration 0.3723745105019637 0.0108949552847327 0.9913072553595526 1.0 1.0 3 P09493,Q14344 2 +Phosphorylation of rna polymerase ii c terminal domain 0.3720185119259605 0.0107830735447696 0.9913965188287792 1.0 1.0 3 Q9NYV4,Q8WUA2 2 +Membrane fission 0.3504273504273492 0.0107192356513624 0.9914474511546636 1.0 1.0 4 Q9ULV4,O00429,Q9H444 3 +Positive regulation of anoikis 0.3684585261658965 0.0097010880616252 0.9922597730197222 1.0 1.0 3 O96017,Q9BQG0 2 +Renal system process 0.2879283104233607 0.0094971233902137 0.9924225057842072 1.0 1.0 9 Q9NQH7,Q9Y5X3 2 +Positive regulation of brown fat cell differentiation 0.3666924205822495 0.0091886357975262 0.9926686325282736 1.0 1.0 3 Q16539 1 +Regulation of bone resorption 0.3656105375578592 0.0088824876423717 0.9929128934425338 1.0 1.0 3 P41240,P02786 2 +Regulation of bone remodeling 0.3656105375578592 0.0088824876423717 0.9929128934425338 1.0 1.0 3 P41240,P02786 2 +Regulation of protein localization to cell cortex 0.3472222222222207 0.0085489595377877 0.9931790002591024 1.0 1.0 4 Q14980,P53350,P11171 3 +Regulation of mitotic centrosome separation 0.3595585617657552 0.0072750221571502 0.994195423343476 1.0 1.0 3 Q9UNZ2,P52732 2 +Regulation of dna helicase activity 0.3577785688857239 0.0068349665997776 0.9945465281378976 1.0 1.0 3 P49736,Q04837 2 +Deoxyribonucleoside monophosphate biosynthetic process 0.3440170940170936 0.0064755381292011 0.9948333042126716 1.0 1.0 4 P04818,P04183,P55263 3 +Regulation of metaphase plate congression 0.343142437652619 0.0059262321537042 0.9952715785380484 1.0 1.0 4 Q96R06 1 +Positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus 0.3517265930936326 0.0054437369013613 0.9956565478258484 1.0 1.0 3 Q06330,P04637 2 +Vesicle tethering 0.3422015232808369 0.0053431188314686 0.9957368282626696 1.0 1.0 4 O95772 1 +Protein methylation 0.2502613186660668 0.0051260268890099 0.9959100401984072 1.0 1.0 54 Q9BYW2,Q99873,Q9H993,O60725,O96028,Q9H7B4,Q86X55,Q03164,Q9BV86 9 +Homotypic cell cell adhesion 0.2605562254142551 0.005115176307335 0.9959186975964996 1.0 1.0 14 Q9Y624,Q14126,Q12955,P04792 4 +Positive regulation of protein localization to cell cortex 0.3470986116055576 0.004483511055303 0.9964226877359006 1.0 1.0 3 Q14980,P11171 2 +Neural nucleus development 0.2624892060920406 0.0042649772059456 0.9965970508518278 1.0 1.0 15 Q8IXJ6,O15027,P00367 3 +Response to platelet derived growth factor 0.3053081581759825 0.0038685112507021 0.9969133822985086 1.0 1.0 5 P56192,P46940,Q13547,Q96A49 4 +Sequestering of metal ion 0.3432293039036518 0.0037452392695526 0.9970117383962795 1.0 1.0 3 Q8NEW0 1 +Interleukin 17 production 0.3380376425154225 0.0028412308597623 0.9977330288133752 1.0 1.0 3 Q01650 1 +Positive regulation of spindle assembly 0.3364186543253875 0.0025785822764752 0.997942591292822 1.0 1.0 3 Q14980,Q96R06 2 +Uv protection 0.3375217936714321 0.002561050389739 0.9979565796683812 1.0 1.0 4 P18074 1 +Positive regulation of protein autophosphorylation 0.3339266642933447 0.0021913856872003 0.9982515285928284 1.0 1.0 3 P49959,O00571 2 +Intrinsic apoptotic signaling pathway in response to oxidative stress 0.268882142786609 0.0020739551930199 0.9983452243579708 1.0 1.0 12 Q9NR28 1 +Regulation of protein modification process 0.2881963689410615 0.0010730443120475 0.9991438346746616 1.0 1.0 269 P30536,Q01105,Q9H2J4,Q9NVN8,Q96FW1,Q5VTR2,O75718,P51116,P14174,Q9Y3I1,P29375,Q13432,Q96GG9,Q03164,O95684,Q16543,Q9BZF1,Q92990,O43823,Q92797,P62942,O75844,P51114,P46109,Q53EL6,Q9NWY4,Q8WXW3,Q12972,Q96ST2,Q969T9,Q15750,Q96S97,P04062,Q96ST3,Q96KB5,Q96DY7,Q13501,Q9H223,Q06124,Q32P28,Q7L7X3,P17931,Q06787,O75832,P42858,P31751,Q92769,O14964,Q86XL3,Q02750,Q9ULX6,P35080,P30153,P04792,O94992,P19474,Q9H7B4,Q8IXJ6,Q07954,P42345 60 +Positive regulation of stress fiber assembly 0.2851479166436754 0.0005483693815637 0.9995624645587616 1.0 1.0 8 P35080,P42345 2 diff --git a/msigdb_gobp/selections.json b/msigdb_gobp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..f223703cd7bc4b1c2c322d23b86a7158389f9a15 --- /dev/null +++ b/msigdb_gobp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["10 formyltetrahydrofolate metabolic process", "2 oxoglutarate metabolic process", "2fe 2s cluster assembly", "3 phosphoadenosine 5 phosphosulfate biosynthetic process", "3 phosphoadenosine 5 phosphosulfate metabolic process", "3 utr mediated mrna destabilization", "3 utr mediated mrna stabilization", "5 phosphoribose 1 diphosphate metabolic process", "5s class rrna transcription by rna polymerase iii", "Abscission", "Acetyl coa biosynthetic process", "Acetyl coa biosynthetic process from pyruvate", "Acetyl coa metabolic process", "Acid secretion", "Acidic amino acid transport", "Acrosome assembly", "Actin crosslink formation", "Actin cytoskeleton reorganization", "Actin filament based movement", "Actin filament based process", "Actin filament based transport", "Actin filament bundle organization", "Actin filament depolymerization", "Actin filament network formation", "Actin filament organization", "Actin filament polymerization", "Actin filament severing", "Actin mediated cell contraction", "Actin modification", "Actin myosin filament sliding", "Actin nucleation", "Actin polymerization dependent cell motility", "Actin polymerization or depolymerization", "Action potential", "Activated t cell proliferation", "Activation induced cell death of t cells", "Activation of adenylate cyclase activity", "Activation of cysteine type endopeptidase activity", "Activation of cysteine type endopeptidase activity involved in apoptotic process", "Activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome c", "Activation of gtpase activity", "Activation of immune response", "Activation of innate immune response", "Activation of janus kinase activity", "Activation of nf kappab inducing kinase activity", "Activation of phospholipase c activity", "Activation of phospholipase d activity", "Activation of protein kinase activity", "Activation of protein kinase b activity", "Activation of protein kinase c activity", "Activin receptor signaling pathway", "Actomyosin contractile ring organization", "Actomyosin structure organization", "Acute inflammatory response", "Acute inflammatory response to antigenic stimulus", "Acute phase response", "Acyl carnitine transmembrane transport", "Acylglycerol homeostasis", "Adaptation of signaling pathway", "Adaptive immune response", "Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", "Adaptive thermogenesis", "Adenosine metabolic process", "Adenosine to inosine editing", "Adenylate cyclase activating adrenergic receptor signaling pathway", "Adenylate cyclase activating adrenergic receptor signaling pathway involved in heart process", "Adenylate cyclase activating dopamine receptor signaling pathway", "Adenylate cyclase activating g protein coupled receptor signaling pathway", "Adenylate cyclase inhibiting dopamine receptor signaling pathway", "Adenylate cyclase inhibiting g protein coupled receptor signaling pathway", "Adenylate cyclase modulating g protein coupled receptor signaling pathway", "Adherens junction assembly", "Adherens junction maintenance", "Adherens junction organization", "Adhesion of symbiont to host", "Adhesion of symbiont to host cell", "Adiponectin activated signaling pathway", "Adipose tissue development", "Adp biosynthetic process", "Adp metabolic process", "Adp transport", "Adrenal gland development", "Adrenergic receptor signaling pathway", "Adult behavior", "Adult heart development", "Adult locomotory behavior", "Aerobic respiration", "Aggrephagy", "Aggresome assembly", "Aging", "Alanine transport", "Alcohol biosynthetic process", "Alcohol catabolic process", "Alcohol metabolic process", "Aldehyde biosynthetic process", "Aldehyde catabolic process", "Alditol biosynthetic process", "Alditol catabolic process", "Alditol metabolic process", "Alditol phosphate metabolic process", "Alkanesulfonate metabolic process", "Allantoin metabolic process", "Alpha amino acid catabolic process", "Alpha amino acid metabolic process", "Alpha beta t cell activation", "Alpha beta t cell differentiation", "Alpha beta t cell proliferation", "Alpha ketoglutarate transport", "Alpha linolenic acid metabolic process", "Alternative mrna splicing via spliceosome", "Ameboidal type cell migration", "Amelogenesis", "Amide biosynthetic process", "Amide transport", "Amine biosynthetic process", "Amine catabolic process", "Amine metabolic process", "Amine transport", "Amino acid activation", "Amino acid betaine biosynthetic process", "Amino acid betaine metabolic process", "Amino acid betaine transport", "Amino acid homeostasis", "Amino acid import", "Amino acid import across plasma membrane", "Amino acid neurotransmitter reuptake", "Amino acid salvage", "Amino acid transmembrane transport", "Amino acid transport", "Amino sugar biosynthetic process", "Amino sugar catabolic process", "Amino sugar metabolic process", "Aminoacyl trna metabolism involved in translational fidelity", "Aminoglycan biosynthetic process", "Aminoglycan catabolic process", "Aminoglycan metabolic process", "Aminoglycoside antibiotic metabolic process", "Aminophospholipid translocation", "Aminophospholipid transport", "Ammonium ion metabolic process", "Ammonium transmembrane transport", "Amp biosynthetic process", "Amp metabolic process", "Amp salvage", "Ampa glutamate receptor clustering", "Amygdala development", "Amyloid beta clearance", "Amyloid beta clearance by cellular catabolic process", "Amyloid beta clearance by transcytosis", "Amyloid beta formation", "Amyloid beta metabolic process", "Amyloid fibril formation", "Amyloid precursor protein biosynthetic process", "Amyloid precursor protein catabolic process", "Amyloid precursor protein metabolic process", "Anagen", "Anaphase promoting complex dependent catabolic process", "Anatomical structure arrangement", "Anatomical structure formation involved in morphogenesis", "Anatomical structure homeostasis", "Anatomical structure maturation", "Androgen catabolic process", "Androgen metabolic process", "Androgen receptor signaling pathway", "Angiogenesis involved in wound healing", "Angiotensin activated signaling pathway", "Animal organ formation", "Animal organ morphogenesis", "Animal organ regeneration", "Anion homeostasis", "Anion transmembrane transport", "Anion transport", "Anoikis", "Anterior head development", "Anterior posterior axis specification", "Anterior posterior pattern specification", "Anterograde axonal transport", "Anterograde axonal transport of mitochondrion", "Anterograde dendritic transport", "Anterograde dendritic transport of neurotransmitter receptor complex", "Anterograde neuronal dense core vesicle transport", "Antibacterial humoral response", "Antigen processing and presentation", "Antigen processing and presentation of endogenous antigen", "Antigen processing and presentation of endogenous peptide antigen", "Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway", "Antigen processing and presentation of exogenous antigen", "Antigen processing and presentation of exogenous peptide antigen", "Antigen processing and presentation of exogenous peptide antigen via mhc class i", "Antigen processing and presentation of exogenous peptide antigen via mhc class ii", "Antigen processing and presentation of lipid antigen via mhc class ib", "Antigen processing and presentation of peptide antigen", "Antigen processing and presentation of peptide antigen via mhc class i", "Antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii", "Antigen processing and presentation via mhc class ib", "Antigen receptor mediated signaling pathway", "Antimicrobial humoral immune response mediated by antimicrobial peptide", "Antimicrobial humoral response", "Antiviral innate immune response", "Aorta development", "Aorta morphogenesis", "Aortic valve morphogenesis", "Apical junction assembly", "Apical protein localization", "Apoptotic cell clearance", "Apoptotic chromosome condensation", "Apoptotic dna fragmentation", "Apoptotic mitochondrial changes", "Apoptotic process involved in development", "Apoptotic process involved in morphogenesis", "Apoptotic signaling pathway", "Appendage development", "Appendage morphogenesis", "Arachidonic acid metabolic process", "Arachidonic acid secretion", "Arf protein signal transduction", "Arginine catabolic process", "Arginine metabolic process", "Aromatic amino acid family catabolic process", "Aromatic amino acid family metabolic process", "Aromatic amino acid transport", "Arp2 3 complex mediated actin nucleation", "Arterial endothelial cell differentiation", "Artery development", "Artery morphogenesis", "Asparagine metabolic process", "Aspartate family amino acid biosynthetic process", "Aspartate family amino acid catabolic process", "Aspartate family amino acid metabolic process", "Aspartate metabolic process", "Aspartate transmembrane transport", "Associative learning", "Astral microtubule organization", "Astrocyte activation", "Astrocyte cell migration", "Astrocyte development", "Astrocyte differentiation", "Asymmetric cell division", "Asymmetric neuroblast division", "Atf6 mediated unfolded protein response", "Atp biosynthetic process", "Atp metabolic process", "Atp synthesis coupled electron transport", "Atp synthesis coupled proton transport", "Atp transport", "Atrial cardiac muscle cell membrane repolarization", "Atrial cardiac muscle cell to av node cell signaling", "Atrial septum development", "Atrial septum morphogenesis", "Atrioventricular canal development", "Attachment of gpi anchor to protein", "Attachment of mitotic spindle microtubules to kinetochore", "Attachment of spindle microtubules to kinetochore", "Auditory receptor cell development", "Auditory receptor cell morphogenesis", "Autonomic nervous system development", "Autophagic cell death", "Autophagosome maturation", "Autophagosome membrane docking", "Autophagosome organization", "Autophagy of mitochondrion", "Autophagy of nucleus", "Autophagy of peroxisome", "Axial mesoderm development", "Axis elongation", "Axis specification", "Axo dendritic protein transport", "Axo dendritic transport", "Axon development", "Axon ensheathment in central nervous system", "Axon extension", "Axonal fasciculation", "Axonal transport", "Axonal transport of mitochondrion", "Axonemal dynein complex assembly", "Axoneme assembly", "Axonogenesis involved in innervation", "Azole transmembrane transport", "B cell activation", "B cell activation involved in immune response", "B cell apoptotic process", "B cell differentiation", "B cell homeostasis", "B cell lineage commitment", "B cell mediated immunity", "B cell proliferation", "B cell receptor signaling pathway", "Barbed end actin filament capping", "Base conversion or substitution editing", "Base excision repair", "Base excision repair ap site formation", "Base excision repair gap filling", "Basement membrane assembly", "Basement membrane organization", "Basic amino acid transport", "Behavior", "Behavioral response to cocaine", "Behavioral response to ethanol", "Behavioral response to pain", "Benzene containing compound metabolic process", "Bergmann glial cell differentiation", "Bile acid and bile salt transport", "Bile acid biosynthetic process", "Bile acid metabolic process", "Bile acid secretion", "Bile acid signaling pathway", "Binding of sperm to zona pellucida", "Biological adhesion", "Biological phase", "Biological process involved in interaction with host", "Biological process involved in interaction with symbiont", "Biological process involved in interspecies interaction between organisms", "Biological process involved in intraspecies interaction between organisms", "Biological process involved in symbiotic interaction", "Biomineralization", "Blastocyst development", "Blastocyst formation", "Blastocyst growth", "Blastoderm segmentation", "Bleb assembly", "Blood vessel endothelial cell differentiation", "Blood vessel endothelial cell migration", "Blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Blood vessel maturation", "Blood vessel morphogenesis", "Blood vessel remodeling", "Body fluid secretion", "Body morphogenesis", "Bone cell development", "Bone development", "Bone growth", "Bone marrow development", "Bone mineralization", "Bone morphogenesis", "Bone remodeling", "Bone resorption", "Box c d snornp assembly", "Bradykinin catabolic process", "Brain derived neurotrophic factor receptor signaling pathway", "Brain morphogenesis", "Brainstem development", "Branched chain amino acid biosynthetic process", "Branched chain amino acid catabolic process", "Branched chain amino acid metabolic process", "Branched chain amino acid transport", "Branching involved in blood vessel morphogenesis", "Branching involved in labyrinthine layer morphogenesis", "Branching involved in mammary gland duct morphogenesis", "Branching morphogenesis of a nerve", "Branching morphogenesis of an epithelial tube", "Branchiomotor neuron axon guidance", "Brown fat cell differentiation", "Bundle of his cell to purkinje myocyte communication", "Bundle of his cell to purkinje myocyte signaling", "C 5 methylation of cytosine", "C terminal protein amino acid modification", "C21 steroid hormone biosynthetic process", "C21 steroid hormone metabolic process", "C4 dicarboxylate transport", "Calcineurin mediated signaling", "Calcium activated phospholipid scrambling", "Calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules", "Calcium import into the mitochondrion", "Calcium ion export", "Calcium ion export across plasma membrane", "Calcium ion import", "Calcium ion import into cytosol", "Calcium ion import into sarcoplasmic reticulum", "Calcium ion regulated exocytosis", "Calcium ion regulated exocytosis of neurotransmitter", "Calcium ion transmembrane transport", "Calcium ion transmembrane transport via high voltage gated calcium channel", "Calcium ion transport", "Calcium ion transport into cytosol", "Calcium mediated signaling", "Calcium mediated signaling using intracellular calcium source", "Calmodulin dependent kinase signaling pathway", "Camera type eye development", "Camera type eye morphogenesis", "Camera type eye photoreceptor cell differentiation", "Camp mediated signaling", "Canonical wnt signaling pathway", "Canonical wnt signaling pathway involved in cardiac muscle cell fate commitment", "Canonical wnt signaling pathway involved in heart development", "Canonical wnt signaling pathway involved in osteoblast differentiation", "Canonical wnt signaling pathway involved in regulation of cell proliferation", "Cap dependent translational initiation", "Carbohydrate biosynthetic process", "Carbohydrate catabolic process", "Carbohydrate derivative biosynthetic process", "Carbohydrate derivative catabolic process", "Carbohydrate derivative metabolic process", "Carbohydrate derivative transport", "Carbohydrate homeostasis", "Carbohydrate import across plasma membrane", "Carbohydrate mediated signaling", "Carbohydrate metabolic process", "Carbohydrate phosphorylation", "Carbohydrate transmembrane transport", "Carbohydrate transport", "Carboxylic acid transport", "Cardiac atrium development", "Cardiac atrium morphogenesis", "Cardiac cell development", "Cardiac cell fate commitment", "Cardiac chamber development", "Cardiac chamber morphogenesis", "Cardiac conduction", "Cardiac conduction system development", "Cardiac epithelial to mesenchymal transition", "Cardiac left ventricle morphogenesis", "Cardiac muscle cell action potential", "Cardiac muscle cell action potential involved in contraction", "Cardiac muscle cell cardiac muscle cell adhesion", "Cardiac muscle cell contraction", "Cardiac muscle cell differentiation", "Cardiac muscle cell fate commitment", "Cardiac muscle cell membrane repolarization", "Cardiac muscle cell myoblast differentiation", "Cardiac muscle cell proliferation", "Cardiac muscle contraction", "Cardiac muscle tissue development", "Cardiac muscle tissue morphogenesis", "Cardiac neural crest cell development involved in outflow tract morphogenesis", "Cardiac neural crest cell differentiation involved in heart development", "Cardiac neural crest cell migration involved in outflow tract morphogenesis", "Cardiac right ventricle morphogenesis", "Cardiac septum development", "Cardiac septum morphogenesis", "Cardiac ventricle development", "Cardiac ventricle morphogenesis", "Cardioblast differentiation", "Cardioblast proliferation", "Cardiocyte differentiation", "Cardiolipin acyl chain remodeling", "Cardiolipin biosynthetic process", "Cardiolipin metabolic process", "Carnitine metabolic process", "Carnitine transport", "Cartilage development", "Cartilage development involved in endochondral bone morphogenesis", "Catechol containing compound biosynthetic process", "Catechol containing compound catabolic process", "Catechol containing compound metabolic process", "Catecholamine uptake", "Catecholamine uptake involved in synaptic transmission", "Cation transmembrane transport", "Cation transport", "Caveola assembly", "Caveolin mediated endocytosis", "Cd4 positive alpha beta t cell activation", "Cd4 positive alpha beta t cell differentiation", "Cd4 positive alpha beta t cell proliferation", "Cd4 positive or cd8 positive alpha beta t cell lineage commitment", "Cd40 signaling pathway", "Cd8 positive alpha beta t cell activation", "Cd8 positive alpha beta t cell differentiation", "Cd8 positive alpha beta t cell proliferation", "Cdc42 protein signal transduction", "Cdp choline pathway", "Cdp diacylglycerol metabolic process", "Cell activation", "Cell activation involved in immune response", "Cell adhesion mediated by integrin", "Cell adhesion molecule production", "Cell aggregation", "Cell aging", "Cell cell adhesion", "Cell cell adhesion involved in gastrulation", "Cell cell adhesion mediated by cadherin", "Cell cell adhesion mediated by integrin", "Cell cell adhesion via plasma membrane adhesion molecules", "Cell cell junction assembly", "Cell cell junction maintenance", "Cell cell junction organization", "Cell cell recognition", "Cell cell signaling", "Cell cell signaling by wnt", "Cell cell signaling involved in cardiac conduction", "Cell chemotaxis", "Cell communication by electrical coupling", "Cell communication by electrical coupling involved in cardiac conduction", "Cell communication involved in cardiac conduction", "Cell cycle", "Cell cycle checkpoint signaling", "Cell cycle dna replication", "Cell cycle dna replication initiation", "Cell cycle g1 s phase transition", "Cell cycle g2 m phase transition", "Cell cycle phase transition", "Cell cycle process", "Cell death in response to hydrogen peroxide", "Cell death in response to oxidative stress", "Cell differentiation in hindbrain", "Cell differentiation in spinal cord", "Cell differentiation involved in embryonic placenta development", "Cell differentiation involved in kidney development", "Cell differentiation involved in metanephros development", "Cell differentiation involved in phenotypic switching", "Cell division", "Cell fate commitment", "Cell fate commitment involved in formation of primary germ layer", "Cell fate determination", "Cell fate specification", "Cell growth", "Cell junction assembly", "Cell junction disassembly", "Cell junction maintenance", "Cell junction organization", "Cell killing", "Cell matrix adhesion", "Cell maturation", "Cell migration", "Cell migration in hindbrain", "Cell migration involved in gastrulation", "Cell migration involved in heart development", "Cell migration involved in sprouting angiogenesis", "Cell morphogenesis", "Cell morphogenesis involved in differentiation", "Cell morphogenesis involved in neuron differentiation", "Cell motility involved in cerebral cortex radial glia guided migration", "Cell part morphogenesis", "Cell projection assembly", "Cell projection organization", "Cell proliferation in bone marrow", "Cell proliferation in forebrain", "Cell proliferation in hindbrain", "Cell proliferation involved in heart morphogenesis", "Cell proliferation involved in kidney development", "Cell proliferation involved in metanephros development", "Cell recognition", "Cell redox homeostasis", "Cell substrate adhesion", "Cell substrate junction organization", "Cell surface receptor signaling pathway involved in cell cell signaling", "Cell surface receptor signaling pathway involved in heart development", "Cell volume homeostasis", "Cellular aldehyde metabolic process", "Cellular amide metabolic process", "Cellular amino acid biosynthetic process", "Cellular amino acid catabolic process", "Cellular amino acid metabolic process", "Cellular anion homeostasis", "Cellular carbohydrate biosynthetic process", "Cellular carbohydrate catabolic process", "Cellular carbohydrate metabolic process", "Cellular component assembly involved in morphogenesis", "Cellular component disassembly", "Cellular component disassembly involved in execution phase of apoptosis", "Cellular component maintenance", "Cellular component morphogenesis", "Cellular copper ion homeostasis", "Cellular defense response", "Cellular detoxification of aldehyde", "Cellular extravasation", "Cellular glucan metabolic process", "Cellular glucose homeostasis", "Cellular homeostasis", "Cellular hormone metabolic process", "Cellular hyperosmotic response", "Cellular hyperosmotic salinity response", "Cellular hypotonic response", "Cellular ion homeostasis", "Cellular iron ion homeostasis", "Cellular ketone metabolic process", "Cellular lipid catabolic process", "Cellular lipid metabolic process", "Cellular macromolecule biosynthetic process", "Cellular macromolecule localization", "Cellular metabolic compound salvage", "Cellular modified amino acid biosynthetic process", "Cellular modified amino acid catabolic process", "Cellular modified amino acid metabolic process", "Cellular monovalent inorganic anion homeostasis", "Cellular monovalent inorganic cation homeostasis", "Cellular nitrogen compound catabolic process", "Cellular oxidant detoxification", "Cellular pigmentation", "Cellular polysaccharide catabolic process", "Cellular potassium ion homeostasis", "Cellular process involved in reproduction in multicellular organism", "Cellular protein catabolic process", "Cellular respiration", "Cellular response to abiotic stimulus", "Cellular response to acid chemical", "Cellular response to acidic ph", "Cellular response to alcohol", "Cellular response to aldehyde", "Cellular response to alkaloid", "Cellular response to amyloid beta", "Cellular response to antibiotic", "Cellular response to arsenic containing substance", "Cellular response to atp", "Cellular response to biotic stimulus", "Cellular response to brain derived neurotrophic factor stimulus", "Cellular response to cadmium ion", "Cellular response to caffeine", "Cellular response to calcium ion", "Cellular response to camp", "Cellular response to carbohydrate stimulus", "Cellular response to chemical stress", "Cellular response to cold", "Cellular response to corticosteroid stimulus", "Cellular response to dexamethasone stimulus", "Cellular response to dna damage stimulus", "Cellular response to dsrna", "Cellular response to electrical stimulus", "Cellular response to endogenous stimulus", "Cellular response to epinephrine stimulus", "Cellular response to estradiol stimulus", "Cellular response to estrogen stimulus", "Cellular response to ethanol", "Cellular response to ether", "Cellular response to exogenous dsrna", "Cellular response to external stimulus", "Cellular response to extracellular stimulus", "Cellular response to fatty acid", "Cellular response to fluid shear stress", "Cellular response to follicle stimulating hormone stimulus", "Cellular response to gamma radiation", "Cellular response to glucose starvation", "Cellular response to gonadotropin stimulus", "Cellular response to growth hormone stimulus", "Cellular response to heat", "Cellular response to heparin", "Cellular response to histamine", "Cellular response to hormone stimulus", "Cellular response to hydrogen peroxide", "Cellular response to hyperoxia", "Cellular response to increased oxygen levels", "Cellular response to indole 3 methanol", "Cellular response to inorganic substance", "Cellular response to insulin like growth factor stimulus", "Cellular response to insulin stimulus", "Cellular response to interferon alpha", "Cellular response to interferon beta", "Cellular response to interferon gamma", "Cellular response to interleukin 1", "Cellular response to ionizing radiation", "Cellular response to iron ion", "Cellular response to ketone", "Cellular response to leptin stimulus", "Cellular response to leucine", "Cellular response to leucine starvation", "Cellular response to light intensity", "Cellular response to light stimulus", "Cellular response to lipid", "Cellular response to lipoprotein particle stimulus", "Cellular response to lithium ion", "Cellular response to low density lipoprotein particle stimulus", "Cellular response to magnesium ion", "Cellular response to manganese ion", "Cellular response to mechanical stimulus", "Cellular response to mineralocorticoid stimulus", "Cellular response to molecule of bacterial origin", "Cellular response to muramyl dipeptide", "Cellular response to nitrogen compound", "Cellular response to nitrogen starvation", "Cellular response to nitrosative stress", "Cellular response to nutrient", "Cellular response to organic cyclic compound", "Cellular response to osmotic stress", "Cellular response to oxidised low density lipoprotein particle stimulus", "Cellular response to oxygen containing compound", "Cellular response to oxygen glucose deprivation", "Cellular response to oxygen levels", "Cellular response to oxygen radical", "Cellular response to parathyroid hormone stimulus", "Cellular response to peptide", "Cellular response to peptide hormone stimulus", "Cellular response to peptidoglycan", "Cellular response to ph", "Cellular response to potassium ion", "Cellular response to progesterone stimulus", "Cellular response to prostaglandin e stimulus", "Cellular response to prostaglandin stimulus", "Cellular response to purine containing compound", "Cellular response to radiation", "Cellular response to reactive nitrogen species", "Cellular response to reactive oxygen species", "Cellular response to retinoic acid", "Cellular response to salt", "Cellular response to salt stress", "Cellular response to sodium arsenite", "Cellular response to starvation", "Cellular response to steroid hormone stimulus", "Cellular response to sterol depletion", "Cellular response to stress", "Cellular response to testosterone stimulus", "Cellular response to thyroid hormone stimulus", "Cellular response to topologically incorrect protein", "Cellular response to toxic substance", "Cellular response to unfolded protein", "Cellular response to uv", "Cellular response to uv a", "Cellular response to uv c", "Cellular response to vascular endothelial growth factor stimulus", "Cellular response to virus", "Cellular response to vitamin", "Cellular response to vitamin d", "Cellular response to water stimulus", "Cellular response to x ray", "Cellular response to xenobiotic stimulus", "Cellular response to zinc ion", "Cellular senescence", "Cellular sodium ion homeostasis", "Cellular sphingolipid homeostasis", "Cellular transition metal ion homeostasis", "Cellular triglyceride homeostasis", "Cellular trivalent inorganic anion homeostasis", "Cenp a containing chromatin organization", "Central nervous system development", "Central nervous system maturation", "Central nervous system myelin formation", "Central nervous system neuron axonogenesis", "Central nervous system neuron development", "Central nervous system neuron differentiation", "Central nervous system projection neuron axonogenesis", "Centriole assembly", "Centriole centriole cohesion", "Centriole elongation", "Centromere complex assembly", "Centromeric sister chromatid cohesion", "Centrosome duplication", "Centrosome separation", "Ceramide biosynthetic process", "Ceramide catabolic process", "Ceramide metabolic process", "Ceramide transport", "Cerebellar cortex development", "Cerebellar cortex formation", "Cerebellar cortex morphogenesis", "Cerebellar granular layer development", "Cerebellar granular layer formation", "Cerebellar granular layer morphogenesis", "Cerebellar purkinje cell layer development", "Cerebellar purkinje cell layer formation", "Cerebellar purkinje cell layer morphogenesis", "Cerebral cortex cell migration", "Cerebral cortex development", "Cerebral cortex neuron differentiation", "Cerebral cortex radially oriented cell migration", "Cerebral cortex regionalization", "Cerebral cortex tangential migration", "Cerebrospinal fluid circulation", "Cgmp mediated signaling", "Changes to dna methylation involved in embryo development", "Chaperone cofactor dependent protein refolding", "Chaperone mediated autophagy", "Chaperone mediated protein complex assembly", "Chaperone mediated protein folding", "Chemical homeostasis", "Chemical homeostasis within a tissue", "Chemical synaptic transmission postsynaptic", "Chemokine c c motif ligand 5 production", "Chemokine c x c motif ligand 2 production", "Chemokine production", "Chemosensory behavior", "Chloride transmembrane transport", "Chloride transport", "Cholesterol catabolic process", "Cholesterol efflux", "Cholesterol storage", "Choline metabolic process", "Chondrocyte development", "Chondrocyte development involved in endochondral bone morphogenesis", "Chondrocyte differentiation", "Chondrocyte differentiation involved in endochondral bone morphogenesis", "Chondrocyte proliferation", "Chondroitin sulfate biosynthetic process", "Chondroitin sulfate proteoglycan biosynthetic process", "Chondroitin sulfate proteoglycan metabolic process", "Chorion development", "Chromatin assembly or disassembly", "Chromatin disassembly", "Chromatin organization", "Chromatin remodeling", "Chromatin remodeling at centromere", "Chromosome attachment to the nuclear envelope", "Chromosome condensation", "Chromosome localization", "Chromosome localization to nuclear envelope involved in homologous chromosome segregation", "Chromosome movement towards spindle pole", "Chromosome organization", "Chromosome organization involved in meiotic cell cycle", "Chromosome segregation", "Chromosome separation", "Cilium movement", "Cilium or flagellum dependent cell motility", "Cilium organization", "Circadian regulation of gene expression", "Circadian rhythm", "Circulatory system development", "Circulatory system process", "Citrate metabolic process", "Citrulline biosynthetic process", "Citrulline metabolic process", "Clathrin coat assembly", "Clathrin dependent endocytosis", "Cleavage furrow formation", "Cleavage involved in rrna processing", "Cobalamin metabolic process", "Cobalamin transport", "Cochlea development", "Cochlea morphogenesis", "Coenzyme a biosynthetic process", "Coenzyme a metabolic process", "Cognition", "Cohesin loading", "Collagen biosynthetic process", "Collagen catabolic process", "Collagen fibril organization", "Collagen metabolic process", "Collateral sprouting", "Collateral sprouting in absence of injury", "Collecting duct development", "Columnar cuboidal epithelial cell development", "Columnar cuboidal epithelial cell differentiation", "Columnar cuboidal epithelial cell maturation", "Common partner smad protein phosphorylation", "Complement activation", "Complement dependent cytotoxicity", "Connective tissue development", "Connective tissue replacement", "Constitutive heterochromatin assembly", "Constitutive secretory pathway", "Convergent extension", "Convergent extension involved in axis elongation", "Cop9 signalosome assembly", "Copi coated vesicle budding", "Copii coated vesicle budding", "Copii coated vesicle cargo loading", "Copper ion homeostasis", "Copper ion transport", "Coronary vasculature development", "Coronary vasculature morphogenesis", "Corpus callosum development", "Corpus callosum morphogenesis", "Cortical actin cytoskeleton organization", "Cortical cytoskeleton organization", "Corticospinal tract morphogenesis", "Corticosteroid hormone secretion", "Corticosteroid receptor signaling pathway", "Cortisol secretion", "Cotranslational protein targeting to membrane", "Cranial ganglion development", "Cranial nerve development", "Cranial skeletal system development", "Craniofacial suture morphogenesis", "Crd mediated mrna stabilization", "Cristae formation", "Cyclic nucleotide biosynthetic process", "Cyclic nucleotide catabolic process", "Cyclic nucleotide mediated signaling", "Cyclic nucleotide metabolic process", "Cyclooxygenase pathway", "Cysteine metabolic process", "Cytidine metabolic process", "Cytidine to uridine editing", "Cytochrome complex assembly", "Cytokine mediated signaling pathway", "Cytokine production", "Cytokine production involved in immune response", "Cytokine production involved in inflammatory response", "Cytokinesis", "Cytokinetic process", "Cytoplasm organization", "Cytoplasmic microtubule organization", "Cytoplasmic pattern recognition receptor signaling pathway", "Cytoplasmic pattern recognition receptor signaling pathway in response to virus", "Cytoplasmic sequestering of nf kappab", "Cytoplasmic sequestering of protein", "Cytoplasmic sequestering of transcription factor", "Cytoplasmic translation", "Cytoplasmic translational elongation", "Cytoplasmic translational initiation", "Cytoskeleton dependent cytokinesis", "Cytoskeleton dependent intracellular transport", "Cytoskeleton organization", "Cytosolic calcium ion transport", "Cytosolic transport", "D amino acid transport", "Damp metabolic process", "De novo amp biosynthetic process", "De novo protein folding", "De novo pyrimidine nucleobase biosynthetic process", "Deadenylation dependent decapping of nuclear transcribed mrna", "Decidualization", "Dedifferentiation", "Defense response", "Defense response to bacterium", "Defense response to fungus", "Defense response to gram negative bacterium", "Defense response to gram positive bacterium", "Defense response to other organism", "Defense response to symbiont", "Defense response to tumor cell", "Definitive erythrocyte differentiation", "Definitive hemopoiesis", "Dehydroascorbic acid transport", "Delamination", "Demethylation", "Dendrite arborization", "Dendrite development", "Dendrite extension", "Dendrite morphogenesis", "Dendrite self avoidance", "Dendritic cell apoptotic process", "Dendritic cell chemotaxis", "Dendritic cell cytokine production", "Dendritic cell differentiation", "Dendritic cell migration", "Dendritic spine development", "Dendritic spine maintenance", "Dendritic spine morphogenesis", "Dendritic transport", "Dense core granule transport", "Deoxyribonucleoside catabolic process", "Deoxyribonucleoside diphosphate metabolic process", "Deoxyribonucleoside metabolic process", "Deoxyribonucleoside monophosphate biosynthetic process", "Deoxyribonucleoside monophosphate catabolic process", "Deoxyribonucleoside monophosphate metabolic process", "Deoxyribonucleoside triphosphate biosynthetic process", "Deoxyribonucleoside triphosphate catabolic process", "Deoxyribonucleoside triphosphate metabolic process", "Deoxyribonucleotide biosynthetic process", "Deoxyribose phosphate catabolic process", "Deoxyribose phosphate metabolic process", "Dephosphorylation", "Dephosphorylation of rna polymerase ii c terminal domain", "Depyrimidination", "Desmosome organization", "Detection of abiotic stimulus", "Detection of biotic stimulus", "Detection of cell density", "Detection of external biotic stimulus", "Detection of light stimulus", "Detection of mechanical stimulus", "Detection of molecule of bacterial origin", "Detection of muscle stretch", "Detection of other organism", "Detection of stimulus", "Detection of virus", "Detection of visible light", "Determination of adult lifespan", "Determination of dorsal ventral asymmetry", "Detoxification", "Detoxification of copper ion", "Detoxification of nitrogen compound", "Development of primary female sexual characteristics", "Development of primary sexual characteristics", "Development of secondary female sexual characteristics", "Development of secondary sexual characteristics", "Developmental cell growth", "Developmental growth", "Developmental growth involved in morphogenesis", "Developmental induction", "Developmental maturation", "Developmental pigmentation", "Developmental process involved in reproduction", "Diacylglycerol biosynthetic process", "Diacylglycerol metabolic process", "Diadenosine polyphosphate catabolic process", "Diadenosine polyphosphate metabolic process", "Diapedesis", "Diaphragm development", "Dicarboxylic acid biosynthetic process", "Dicarboxylic acid catabolic process", "Dicarboxylic acid metabolic process", "Dicarboxylic acid transport", "Diencephalon development", "Diet induced thermogenesis", "Digestion", "Digestive system development", "Digestive system process", "Digestive tract morphogenesis", "Diol biosynthetic process", "Diol metabolic process", "Diphosphoinositol polyphosphate metabolic process", "Disaccharide metabolic process", "Diterpenoid biosynthetic process", "Divalent inorganic cation homeostasis", "Dna biosynthetic process", "Dna catabolic process", "Dna catabolic process endonucleolytic", "Dna catabolic process exonucleolytic", "Dna conformation change", "Dna cytosine deamination", "Dna damage induced protein phosphorylation", "Dna damage response signal transduction by p53 class mediator", "Dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest", "Dna damage response signal transduction resulting in transcription", "Dna dealkylation", "Dna dealkylation involved in dna repair", "Dna deamination", "Dna dependent dna replication", "Dna dependent dna replication maintenance of fidelity", "Dna double strand break processing", "Dna endoreduplication", "Dna geometric change", "Dna integration", "Dna integrity checkpoint signaling", "Dna ligation", "Dna ligation involved in dna repair", "Dna metabolic process", "Dna methylation", "Dna methylation dependent heterochromatin assembly", "Dna methylation involved in gamete generation", "Dna methylation on cytosine", "Dna methylation or demethylation", "Dna modification", "Dna packaging", "Dna protection", "Dna recombination", "Dna repair", "Dna replication", "Dna replication checkpoint signaling", "Dna replication dependent chromatin organization", "Dna replication independent chromatin organization", "Dna replication initiation", "Dna replication synthesis of rna primer", "Dna strand elongation", "Dna strand elongation involved in dna replication", "Dna synthesis involved in dna repair", "Dna templated transcription elongation", "Dna templated transcription initiation", "Dna templated transcription termination", "Dna topological change", "Dna unwinding involved in dna replication", "Dolichol metabolic process", "Dopamine biosynthetic process", "Dopamine metabolic process", "Dopamine receptor signaling pathway", "Dopamine transport", "Dopaminergic neuron differentiation", "Dorsal aorta development", "Dorsal aorta morphogenesis", "Dorsal root ganglion development", "Dorsal ventral axis specification", "Dorsal ventral neural tube patterning", "Dorsal ventral pattern formation", "Dosage compensation", "Double strand break repair", "Double strand break repair involved in meiotic recombination", "Double strand break repair via break induced replication", "Double strand break repair via classical nonhomologous end joining", "Double strand break repair via nonhomologous end joining", "Dsrna processing", "Dtmp metabolic process", "Dttp metabolic process", "Dump metabolic process", "Ear development", "Ear morphogenesis", "Early endosome to golgi transport", "Eating behavior", "Ectoderm development", "Ectodermal placode development", "Ectopic germ cell programmed cell death", "Egg activation", "Electron transport chain", "Embryo development", "Embryo development ending in birth or egg hatching", "Embryo implantation", "Embryonic appendage morphogenesis", "Embryonic axis specification", "Embryonic body morphogenesis", "Embryonic brain development", "Embryonic cleavage", "Embryonic cranial skeleton morphogenesis", "Embryonic digestive tract development", "Embryonic digestive tract morphogenesis", "Embryonic digit morphogenesis", "Embryonic forelimb morphogenesis", "Embryonic heart tube development", "Embryonic heart tube morphogenesis", "Embryonic hemopoiesis", "Embryonic hindlimb morphogenesis", "Embryonic morphogenesis", "Embryonic neurocranium morphogenesis", "Embryonic organ development", "Embryonic organ morphogenesis", "Embryonic pattern specification", "Embryonic placenta development", "Embryonic placenta morphogenesis", "Embryonic process involved in female pregnancy", "Embryonic skeletal joint development", "Embryonic skeletal joint morphogenesis", "Embryonic skeletal system development", "Embryonic skeletal system morphogenesis", "Embryonic viscerocranium morphogenesis", "Enamel mineralization", "Endocardial cushion development", "Endocardial cushion formation", "Endocardial cushion morphogenesis", "Endocardium development", "Endocardium morphogenesis", "Endochondral bone morphogenesis", "Endocrine hormone secretion", "Endocrine pancreas development", "Endocrine process", "Endocrine system development", "Endocytic recycling", "Endocytosis", "Endocytosis involved in viral entry into host cell", "Endoderm development", "Endoderm formation", "Endodermal cell differentiation", "Endodermal cell fate commitment", "Endomembrane system organization", "Endonucleolytic cleavage in 5 ets of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage in its1 to separate ssu rrna from 5 8s rrna and lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Endonucleolytic cleavage involved in rrna processing", "Endoplasmic reticulum calcium ion homeostasis", "Endoplasmic reticulum localization", "Endoplasmic reticulum mannose trimming", "Endoplasmic reticulum membrane organization", "Endoplasmic reticulum organization", "Endoplasmic reticulum plasma membrane tethering", "Endoplasmic reticulum to cytosol transport", "Endoplasmic reticulum to golgi vesicle mediated transport", "Endoplasmic reticulum tubular network organization", "Endoplasmic reticulum unfolded protein response", "Endosomal lumen acidification", "Endosomal transport", "Endosomal vesicle fusion", "Endosome organization", "Endosome to lysosome transport", "Endosome to lysosome transport via multivesicular body sorting pathway", "Endosome to plasma membrane protein transport", "Endosome transport via multivesicular body sorting pathway", "Endothelial cell activation", "Endothelial cell apoptotic process", "Endothelial cell chemotaxis", "Endothelial cell development", "Endothelial cell fate commitment", "Endothelial cell matrix adhesion", "Endothelial cell migration", "Endothelial cell morphogenesis", "Endothelial cell proliferation", "Endothelin receptor signaling pathway", "Endothelium development", "Energy derivation by oxidation of organic compounds", "Energy homeostasis", "Energy reserve metabolic process", "Engulfment of apoptotic cell", "Ensheathment of neurons", "Enteroendocrine cell differentiation", "Entrainment of circadian clock", "Entry into host", "Entry of bacterium into host cell", "Enzyme directed rrna pseudouridine synthesis", "Enzyme linked receptor protein signaling pathway", "Eosinophil activation", "Eosinophil chemotaxis", "Eosinophil mediated immunity", "Eosinophil migration", "Ephrin receptor signaling pathway", "Epiboly", "Epidermal cell differentiation", "Epidermis development", "Epidermis morphogenesis", "Epigenetic maintenance of chromatin in transcription competent conformation", "Epithelial cell apoptotic process", "Epithelial cell cell adhesion", "Epithelial cell development", "Epithelial cell differentiation", "Epithelial cell differentiation involved in kidney development", "Epithelial cell differentiation involved in prostate gland development", "Epithelial cell fate commitment", "Epithelial cell maturation", "Epithelial cell morphogenesis", "Epithelial cell proliferation", "Epithelial cell proliferation involved in lung morphogenesis", "Epithelial cell proliferation involved in prostate gland development", "Epithelial fluid transport", "Epithelial structure maintenance", "Epithelial to mesenchymal transition", "Epithelial to mesenchymal transition involved in endocardial cushion formation", "Epithelial tube branching involved in lung morphogenesis", "Epithelial tube formation", "Epithelial tube morphogenesis", "Epithelium development", "Epoxide metabolic process", "Er associated misfolded protein catabolic process", "Er nucleus signaling pathway", "Er overload response", "Erad pathway", "Erbb signaling pathway", "Erbb2 signaling pathway", "Erk1 and erk2 cascade", "Error free translesion synthesis", "Error prone translesion synthesis", "Erythrocyte development", "Erythrocyte homeostasis", "Erythrocyte maturation", "Escrt complex disassembly", "Establishment of cell polarity", "Establishment of centrosome localization", "Establishment of endothelial barrier", "Establishment of endothelial intestinal barrier", "Establishment of epithelial cell apical basal polarity", "Establishment of epithelial cell polarity", "Establishment of golgi localization", "Establishment of lymphocyte polarity", "Establishment of meiotic spindle localization", "Establishment of mitochondrion localization", "Establishment of mitotic spindle localization", "Establishment of organelle localization", "Establishment of pigment granule localization", "Establishment of planar polarity involved in neural tube closure", "Establishment of planar polarity of embryonic epithelium", "Establishment of protein localization", "Establishment of protein localization to chromatin", "Establishment of protein localization to chromosome", "Establishment of protein localization to endoplasmic reticulum", "Establishment of protein localization to membrane", "Establishment of protein localization to mitochondrial membrane", "Establishment of protein localization to organelle", "Establishment of protein localization to plasma membrane", "Establishment of protein localization to telomere", "Establishment of protein localization to vacuole", "Establishment of rna localization", "Establishment of sister chromatid cohesion", "Establishment of spindle orientation", "Establishment of tissue polarity", "Establishment or maintenance of bipolar cell polarity", "Establishment or maintenance of cell polarity", "Establishment or maintenance of cytoskeleton polarity", "Establishment or maintenance of monopolar cell polarity", "Establishment or maintenance of transmembrane electrochemical gradient", "Estrogen biosynthetic process", "Estrogen metabolic process", "Estrous cycle", "Ethanol catabolic process", "Ethanol metabolic process", "Ethanol oxidation", "Ethanolamine containing compound metabolic process", "Ether biosynthetic process", "Ether metabolic process", "Excretion", "Execution phase of apoptosis", "Exit from mitosis", "Exocrine pancreas development", "Exocrine system development", "Exocytic process", "Exocytosis", "Exonucleolytic catabolism of deadenylated mrna", "Exploration behavior", "Export across plasma membrane", "Export from cell", "External encapsulating structure organization", "Extracellular exosome assembly", "Extracellular matrix assembly", "Extracellular matrix disassembly", "Extracellular regulation of signal transduction", "Extracellular transport", "Extracellular vesicle biogenesis", "Extraembryonic membrane development", "Extrinsic apoptotic signaling pathway", "Extrinsic apoptotic signaling pathway via death domain receptors", "Eye morphogenesis", "Eye photoreceptor cell development", "Eye photoreceptor cell differentiation", "Eyelid development in camera type eye", "Face development", "Facultative heterochromatin assembly", "Farnesyl diphosphate metabolic process", "Fas signaling pathway", "Fat cell differentiation", "Fat cell proliferation", "Fat soluble vitamin metabolic process", "Fatty acid alpha oxidation", "Fatty acid beta oxidation", "Fatty acid beta oxidation using acyl coa dehydrogenase", "Fatty acid beta oxidation using acyl coa oxidase", "Fatty acid biosynthetic process", "Fatty acid catabolic process", "Fatty acid derivative biosynthetic process", "Fatty acid derivative catabolic process", "Fatty acid derivative metabolic process", "Fatty acid elongation", "Fatty acid homeostasis", "Fatty acid metabolic process", "Fatty acid omega oxidation", "Fatty acid transmembrane transport", "Fatty acid transport", "Fatty acyl coa biosynthetic process", "Fatty acyl coa catabolic process", "Fatty acyl coa metabolic process", "Fc epsilon receptor signaling pathway", "Fc gamma receptor signaling pathway", "Fc receptor mediated stimulatory signaling pathway", "Fc receptor signaling pathway", "Fear response", "Feeding behavior", "Female gamete generation", "Female genitalia development", "Female meiosis chromosome segregation", "Female meiosis i", "Female meiotic nuclear division", "Female sex differentiation", "Fermentation", "Fertilization", "Fibroblast activation", "Fibroblast apoptotic process", "Fibroblast growth factor receptor signaling pathway", "Fibroblast migration", "Fibroblast proliferation", "Filopodium assembly", "Flavin containing compound metabolic process", "Flavonoid metabolic process", "Fluid transport", "Foam cell differentiation", "Focal adhesion assembly", "Folate transmembrane transport", "Folic acid containing compound biosynthetic process", "Folic acid containing compound catabolic process", "Folic acid containing compound metabolic process", "Folic acid metabolic process", "Folic acid transport", "Forebrain cell migration", "Forebrain development", "Forebrain dorsal ventral pattern formation", "Forebrain generation of neurons", "Forebrain morphogenesis", "Forebrain neuron development", "Forebrain neuron differentiation", "Forebrain regionalization", "Foregut morphogenesis", "Forelimb morphogenesis", "Formate metabolic process", "Formation of extrachromosomal circular dna", "Formation of primary germ layer", "Formation of translation preinitiation complex", "Free ubiquitin chain polymerization", "Fructose 1 6 bisphosphate metabolic process", "Fructose 2 6 bisphosphate metabolic process", "Fructose 6 phosphate metabolic process", "Fructose metabolic process", "Fucose metabolic process", "Fungiform papilla development", "Fungiform papilla morphogenesis", "G protein coupled acetylcholine receptor signaling pathway", "G protein coupled opioid receptor signaling pathway", "G protein coupled purinergic receptor signaling pathway", "G protein coupled receptor internalization", "G protein coupled receptor signaling pathway", "G protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger", "G protein coupled receptor signaling pathway involved in heart process", "G quadruplex dna unwinding", "G0 to g1 transition", "G1 to g0 transition", "G2 mi transition of meiotic cell cycle", "Galactose catabolic process", "Galactose metabolic process", "Gamete generation", "Gamma aminobutyric acid metabolic process", "Gamma aminobutyric acid secretion", "Gamma aminobutyric acid signaling pathway", "Gamma aminobutyric acid transport", "Ganglion development", "Ganglioside catabolic process", "Ganglioside metabolic process", "Gap junction assembly", "Gap junction mediated intercellular transport", "Gas homeostasis", "Gastrulation", "Gastrulation with mouth forming second", "Gdp mannose metabolic process", "Gdp metabolic process", "Gene silencing by rna", "Generation of precursor metabolites and energy", "Genitalia development", "Genitalia morphogenesis", "Genomic imprinting", "Germ cell development", "Germ cell migration", "Germ cell proliferation", "Gland development", "Gland morphogenesis", "Glandular epithelial cell development", "Glandular epithelial cell differentiation", "Glial cell apoptotic process", "Glial cell development", "Glial cell differentiation", "Glial cell fate commitment", "Glial cell migration", "Glial cell proliferation", "Gliogenesis", "Glomerular epithelial cell development", "Glomerular epithelial cell differentiation", "Glomerular epithelium development", "Glomerular visceral epithelial cell migration", "Glomerulus development", "Glucan biosynthetic process", "Glucocorticoid biosynthetic process", "Glucocorticoid metabolic process", "Glucocorticoid secretion", "Glucosamine containing compound catabolic process", "Glucosamine containing compound metabolic process", "Glucose 6 phosphate metabolic process", "Glucose catabolic process", "Glucose import", "Glucose import across plasma membrane", "Glucose import in response to insulin stimulus", "Glucose metabolic process", "Glucosylceramide metabolic process", "Glutamate biosynthetic process", "Glutamate catabolic process", "Glutamate homeostasis", "Glutamate metabolic process", "Glutamate receptor signaling pathway", "Glutamate reuptake", "Glutamate secretion", "Glutamate secretion neurotransmission", "Glutamine family amino acid biosynthetic process", "Glutamine family amino acid catabolic process", "Glutamine family amino acid metabolic process", "Glutamine metabolic process", "Glutamine transport", "Glutathione metabolic process", "Glycerol 3 phosphate metabolic process", "Glycerol ether metabolic process", "Glycerolipid biosynthetic process", "Glycerolipid catabolic process", "Glycerolipid metabolic process", "Glycerophospholipid biosynthetic process", "Glycerophospholipid catabolic process", "Glycerophospholipid metabolic process", "Glycine biosynthetic process", "Glycine metabolic process", "Glycolipid biosynthetic process", "Glycolipid catabolic process", "Glycolipid transport", "Glycolytic fermentation", "Glycolytic process through fructose 6 phosphate", "Glycoprotein biosynthetic process", "Glycoprotein catabolic process", "Glycoprotein metabolic process", "Glycosaminoglycan catabolic process", "Glycoside catabolic process", "Glycoside metabolic process", "Glycosphingolipid biosynthetic process", "Glycosphingolipid metabolic process", "Glycosyl compound biosynthetic process", "Glycosyl compound catabolic process", "Glycosyl compound metabolic process", "Glycosylation", "Glycosylceramide biosynthetic process", "Glycosylceramide catabolic process", "Glycosylceramide metabolic process", "Glyoxylate metabolic process", "Gmp biosynthetic process", "Gmp metabolic process", "Gmp salvage", "Golgi disassembly", "Golgi localization", "Golgi organization", "Golgi ribbon formation", "Golgi to endosome transport", "Golgi to lysosome transport", "Golgi to plasma membrane protein transport", "Golgi to plasma membrane transport", "Golgi to vacuole transport", "Golgi vesicle budding", "Golgi vesicle transport", "Gpi anchor metabolic process", "Granulocyte activation", "Granulocyte chemotaxis", "Granulocyte differentiation", "Granulocyte migration", "Granzyme mediated programmed cell death signaling pathway", "Grooming behavior", "Growth", "Growth hormone receptor signaling pathway via jak stat", "Growth hormone secretion", "Growth plate cartilage chondrocyte differentiation", "Growth plate cartilage development", "Gtp biosynthetic process", "Gtp metabolic process", "Guanine metabolic process", "Hair cell differentiation", "Hair cycle phase", "Hair follicle maturation", "Hair follicle placode formation", "Head development", "Head morphogenesis", "Heart development", "Heart field specification", "Heart formation", "Heart growth", "Heart morphogenesis", "Heart process", "Heart trabecula formation", "Heart trabecula morphogenesis", "Heart valve development", "Heart valve morphogenesis", "Heat acclimation", "Hematopoietic progenitor cell differentiation", "Hematopoietic stem cell differentiation", "Hematopoietic stem cell homeostasis", "Hematopoietic stem cell proliferation", "Heme transport", "Hemidesmosome assembly", "Hemoglobin biosynthetic process", "Hemoglobin metabolic process", "Hemostasis", "Heparan sulfate proteoglycan biosynthetic process", "Heparan sulfate proteoglycan biosynthetic process enzymatic modification", "Heparan sulfate proteoglycan biosynthetic process polysaccharide chain biosynthetic process", "Heparan sulfate proteoglycan metabolic process", "Hepatic stellate cell activation", "Hepaticobiliary system development", "Hepatocyte apoptotic process", "Hepatocyte differentiation", "Hepatocyte growth factor receptor signaling pathway", "Hepoxilin metabolic process", "Heterochromatin organization", "Heterophilic cell cell adhesion via plasma membrane cell adhesion molecules", "Heterotypic cell cell adhesion", "High density lipoprotein particle assembly", "High density lipoprotein particle clearance", "High density lipoprotein particle remodeling", "Hindbrain development", "Hindbrain maturation", "Hindbrain morphogenesis", "Hindbrain radial glia guided cell migration", "Hindlimb morphogenesis", "Hippo signaling", "Hippocampus development", "His purkinje system development", "Histamine production involved in inflammatory response", "Histamine secretion", "Histamine transport", "Histidine metabolic process", "Histone arginine methylation", "Histone deacetylation", "Histone dephosphorylation", "Histone deubiquitination", "Histone exchange", "Histone h2a acetylation", "Histone h2a k119 monoubiquitination", "Histone h2a k63 linked ubiquitination", "Histone h2a monoubiquitination", "Histone h2a phosphorylation", "Histone h2a ubiquitination", "Histone h2b ubiquitination", "Histone h3 acetylation", "Histone h3 deacetylation", "Histone h3 k14 acetylation", "Histone h3 k27 methylation", "Histone h3 k27 trimethylation", "Histone h3 k36 demethylation", "Histone h3 k36 methylation", "Histone h3 k36 trimethylation", "Histone h3 k4 demethylation", "Histone h3 k4 demethylation trimethyl h3 k4 specific", "Histone h3 k4 dimethylation", "Histone h3 k4 methylation", "Histone h3 k4 monomethylation", "Histone h3 k4 trimethylation", "Histone h3 k9 acetylation", "Histone h3 k9 demethylation", "Histone h3 k9 dimethylation", "Histone h3 k9 methylation", "Histone h3 k9 modification", "Histone h3 k9 trimethylation", "Histone h4 acetylation", "Histone h4 deacetylation", "Histone h4 k12 acetylation", "Histone h4 k16 acetylation", "Histone h4 k20 methylation", "Histone h4 k20 trimethylation", "Histone h4 k5 acetylation", "Histone h4 r3 methylation", "Histone lysine demethylation", "Histone methylation", "Histone modification", "Histone monoubiquitination", "Histone mrna catabolic process", "Histone mrna metabolic process", "Histone phosphorylation", "Histone serine phosphorylation", "Histone threonine phosphorylation", "Histone ubiquitination", "Homeostasis of number of cells", "Homeostasis of number of cells within a tissue", "Homeostatic process", "Homocysteine metabolic process", "Homologous chromosome pairing at meiosis", "Homologous chromosome segregation", "Homologous recombination", "Homophilic cell adhesion via plasma membrane adhesion molecules", "Homotypic cell cell adhesion", "Hormone biosynthetic process", "Hormone catabolic process", "Hormone mediated signaling pathway", "Hormone metabolic process", "Hormone transport", "Humoral immune response", "Humoral immune response mediated by circulating immunoglobulin", "Hyaluronan biosynthetic process", "Hyaluronan metabolic process", "Hydrogen peroxide biosynthetic process", "Hydrogen peroxide catabolic process", "Hydrogen peroxide metabolic process", "Hydrogen sulfide biosynthetic process", "Hydrogen sulfide metabolic process", "Hyperosmotic response", "Hyperosmotic salinity response", "Hypothalamus cell differentiation", "Hypothalamus development", "Hypotonic response", "Hypoxia inducible factor 1alpha signaling pathway", "I kappab kinase nf kappab signaling", "I kappab phosphorylation", "Icosanoid biosynthetic process", "Icosanoid metabolic process", "Icosanoid transport", "Immune effector process", "Immune response", "Immune response regulating cell surface receptor signaling pathway", "Immune response regulating signaling pathway", "Immune response to tumor cell", "Immune system development", "Immunoglobulin production", "Immunoglobulin production involved in immunoglobulin mediated immune response", "Immunoglobulin v d j recombination", "Immunological synapse formation", "Imp biosynthetic process", "Imp catabolic process", "Imp metabolic process", "Imp salvage", "Import across plasma membrane", "Import into cell", "Import into nucleus", "In utero embryonic development", "Inclusion body assembly", "Indolalkylamine metabolic process", "Indole containing compound biosynthetic process", "Indole containing compound metabolic process", "Inflammasome complex assembly", "Inflammatory cell apoptotic process", "Inflammatory response", "Inflammatory response to antigenic stimulus", "Inflammatory response to wounding", "Innate immune response", "Innate immune response activating signal transduction", "Innate immune response in mucosa", "Inner cell mass cell differentiation", "Inner cell mass cell proliferation", "Inner dynein arm assembly", "Inner ear auditory receptor cell differentiation", "Inner ear morphogenesis", "Inner ear receptor cell development", "Inner ear receptor cell fate commitment", "Inner ear receptor cell stereocilium organization", "Inner mitochondrial membrane organization", "Innervation", "Inorganic anion transmembrane transport", "Inorganic anion transport", "Inorganic ion import across plasma membrane", "Inorganic ion transmembrane transport", "Inosine metabolic process", "Inositol lipid mediated signaling", "Inositol metabolic process", "Inositol phosphate catabolic process", "Inositol phosphate mediated signaling", "Inositol phosphate metabolic process", "Inositol trisphosphate metabolic process", "Insulin like growth factor receptor signaling pathway", "Insulin metabolic process", "Insulin processing", "Insulin receptor signaling pathway", "Insulin secretion", "Insulin secretion involved in cellular response to glucose stimulus", "Integrated stress response signaling", "Integrin activation", "Integrin mediated signaling pathway", "Intercellular transport", "Interferon alpha production", "Interferon beta production", "Interferon gamma mediated signaling pathway", "Interferon gamma production", "Interleukin 1 mediated signaling pathway", "Interleukin 1 production", "Interleukin 10 production", "Interleukin 12 production", "Interleukin 13 production", "Interleukin 17 production", "Interleukin 18 production", "Interleukin 2 production", "Interleukin 23 production", "Interleukin 27 mediated signaling pathway", "Interleukin 4 production", "Interleukin 6 mediated signaling pathway", "Interleukin 6 production", "Interleukin 8 production", "Intermediate filament based process", "Intermediate filament bundle assembly", "Intermediate filament organization", "Intermembrane lipid transfer", "Interstrand cross link repair", "Intestinal absorption", "Intestinal epithelial cell development", "Intestinal epithelial cell differentiation", "Intestinal hexose absorption", "Intestinal lipid absorption", "Intra golgi vesicle mediated transport", "Intracellular distribution of mitochondria", "Intracellular estrogen receptor signaling pathway", "Intracellular lipid transport", "Intracellular mrna localization", "Intracellular protein transmembrane transport", "Intracellular protein transport", "Intracellular receptor signaling pathway", "Intracellular sterol transport", "Intracellular transport", "Intracellular transport of virus", "Intraciliary retrograde transport", "Intraciliary transport", "Intraciliary transport involved in cilium assembly", "Intrinsic apoptotic signaling pathway", "Intrinsic apoptotic signaling pathway by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to dna damage", "Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "Intrinsic apoptotic signaling pathway in response to hydrogen peroxide", "Intrinsic apoptotic signaling pathway in response to hypoxia", "Intrinsic apoptotic signaling pathway in response to osmotic stress", "Intrinsic apoptotic signaling pathway in response to oxidative stress", "Ion homeostasis", "Ion transmembrane transport", "Ion transport", "Ire1 mediated unfolded protein response", "Ires dependent viral translational initiation", "Iron coordination entity transport", "Iron ion homeostasis", "Iron ion transmembrane transport", "Iron ion transport", "Iron sulfur cluster assembly", "Isocitrate metabolic process", "Isoleucine metabolic process", "Isopentenyl diphosphate biosynthetic process", "Isoprenoid biosynthetic process", "Isoprenoid metabolic process", "Isotype switching to iga isotypes", "Isotype switching to igg isotypes", "Jnk cascade", "Keratan sulfate metabolic process", "Keratinization", "Keratinocyte development", "Keratinocyte differentiation", "Keratinocyte migration", "Keratinocyte proliferation", "Ketone biosynthetic process", "Ketone body biosynthetic process", "Ketone body metabolic process", "Ketone catabolic process", "Kidney epithelium development", "Kidney mesenchyme development", "Kidney morphogenesis", "Killing by host of symbiont cells", "Killing of cells of another organism", "Kinetochore assembly", "Kinetochore organization", "Kynurenine metabolic process", "L alanine transport", "L alpha amino acid transmembrane transport", "L amino acid transport", "L arginine import across plasma membrane", "L arginine transmembrane transport", "L ascorbic acid metabolic process", "L aspartate transmembrane transport", "L glutamate import across plasma membrane", "L glutamate transmembrane transport", "L histidine transmembrane transport", "L kynurenine metabolic process", "L lysine transmembrane transport", "L methionine salvage from methylthioadenosine", "L phenylalanine metabolic process", "L proline biosynthetic process", "L serine biosynthetic process", "L serine catabolic process", "L serine metabolic process", "L serine transport", "Labyrinthine layer blood vessel development", "Labyrinthine layer development", "Labyrinthine layer morphogenesis", "Lactate metabolic process", "Lactate transmembrane transport", "Lactation", "Lamellipodium assembly", "Lamellipodium morphogenesis", "Lamellipodium organization", "Late endosome to golgi transport", "Late endosome to lysosome transport", "Late endosome to vacuole transport", "Late endosome to vacuole transport via multivesicular body sorting pathway", "Late nucleophagy", "Lateral ventricle development", "Layer formation in cerebral cortex", "Learned vocalization behavior or vocal learning", "Learning", "Left right axis specification", "Left right pattern formation", "Lens development in camera type eye", "Lens fiber cell development", "Lens fiber cell differentiation", "Lens morphogenesis in camera type eye", "Leptin mediated signaling pathway", "Leucine catabolic process", "Leucine import across plasma membrane", "Leucine metabolic process", "Leucine transport", "Leukocyte adhesion to vascular endothelial cell", "Leukocyte aggregation", "Leukocyte apoptotic process", "Leukocyte cell cell adhesion", "Leukocyte chemotaxis", "Leukocyte degranulation", "Leukocyte differentiation", "Leukocyte homeostasis", "Leukocyte mediated cytotoxicity", "Leukocyte mediated immunity", "Leukocyte migration", "Leukocyte proliferation", "Leukocyte tethering or rolling", "Leukotriene b4 metabolic process", "Leukotriene biosynthetic process", "Leukotriene metabolic process", "Leukotriene transport", "Leydig cell differentiation", "Limb joint morphogenesis", "Limbic system development", "Linoleic acid metabolic process", "Lipid biosynthetic process", "Lipid catabolic process", "Lipid digestion", "Lipid droplet formation", "Lipid droplet organization", "Lipid export from cell", "Lipid glycosylation", "Lipid homeostasis", "Lipid import into cell", "Lipid localization", "Lipid metabolic process", "Lipid modification", "Lipid oxidation", "Lipid phosphorylation", "Lipid storage", "Lipid translocation", "Lipid transport across blood brain barrier", "Lipophagy", "Lipopolysaccharide mediated signaling pathway", "Lipoprotein biosynthetic process", "Lipoprotein catabolic process", "Lipoprotein localization", "Lipoprotein metabolic process", "Liposaccharide metabolic process", "Lipoxin metabolic process", "Liver morphogenesis", "Liver regeneration", "Localization within membrane", "Locomotion", "Locomotion involved in locomotory behavior", "Locomotor rhythm", "Locomotory behavior", "Locomotory exploration behavior", "Long chain fatty acid biosynthetic process", "Long chain fatty acid import across plasma membrane", "Long chain fatty acid metabolic process", "Long chain fatty acid transport", "Long chain fatty acyl coa biosynthetic process", "Long chain fatty acyl coa metabolic process", "Long term memory", "Long term synaptic depression", "Long term synaptic potentiation", "Low density lipoprotein particle clearance", "Low density lipoprotein receptor particle metabolic process", "Lung alveolus development", "Lung associated mesenchyme development", "Lung cell differentiation", "Lung epithelium development", "Lung morphogenesis", "Lung saccule development", "Lung secretory cell differentiation", "Luteinization", "Luteolysis", "Lymphocyte activation", "Lymphocyte activation involved in immune response", "Lymphocyte aggregation", "Lymphocyte anergy", "Lymphocyte apoptotic process", "Lymphocyte chemotaxis", "Lymphocyte costimulation", "Lymphocyte homeostasis", "Lymphocyte mediated immunity", "Lymphocyte migration", "Lymphocyte migration into lymphoid organs", "Lymphoid progenitor cell differentiation", "Lysine catabolic process", "Lysine metabolic process", "Lysosomal lumen acidification", "Lysosomal membrane organization", "Lysosomal protein catabolic process", "Lysosomal transport", "Lytic vacuole organization", "Macroautophagy", "Macromolecule catabolic process", "Macromolecule deacylation", "Macromolecule depalmitoylation", "Macrophage activation", "Macrophage apoptotic process", "Macrophage chemotaxis", "Macrophage cytokine production", "Macrophage differentiation", "Macrophage inflammatory protein 1 alpha production", "Macrophage migration", "Macrophage proliferation", "Macropinocytosis", "Magnesium ion homeostasis", "Magnesium ion transport", "Maintenance of apical basal cell polarity", "Maintenance of blood brain barrier", "Maintenance of cell number", "Maintenance of cell polarity", "Maintenance of centrosome location", "Maintenance of dna methylation", "Maintenance of dna repeat elements", "Maintenance of gastrointestinal epithelium", "Maintenance of lens transparency", "Maintenance of location", "Maintenance of location in cell", "Maintenance of organelle location", "Maintenance of postsynaptic specialization structure", "Maintenance of presynaptic active zone structure", "Maintenance of protein localization in endoplasmic reticulum", "Maintenance of protein localization in organelle", "Maintenance of protein location", "Maintenance of protein location in cell", "Maintenance of protein location in mitochondrion", "Maintenance of protein location in nucleus", "Maintenance of sister chromatid cohesion", "Maintenance of synapse structure", "Malate metabolic process", "Male gamete generation", "Male genitalia development", "Male mating behavior", "Male meiosis i", "Male meiotic nuclear division", "Male sex determination", "Male sex differentiation", "Malonyl coa metabolic process", "Mammalian oogenesis stage", "Mammary gland alveolus development", "Mammary gland development", "Mammary gland duct morphogenesis", "Mammary gland epithelial cell differentiation", "Mammary gland epithelial cell proliferation", "Mammary gland epithelium development", "Mammary gland involution", "Mammary gland morphogenesis", "Manganese ion transmembrane transport", "Manganese ion transport", "Mannose metabolic process", "Mannosylation", "Mapk cascade", "Mast cell activation", "Mast cell activation involved in immune response", "Mast cell cytokine production", "Mast cell migration", "Maternal placenta development", "Maternal process involved in female pregnancy", "Mating", "Mating behavior", "Maturation of 5 8s rrna", "Maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of lsu rrna", "Maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Maturation of ssu rrna", "Maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna", "Mature ribosome assembly", "Mda 5 signaling pathway", "Mechanoreceptor differentiation", "Mechanosensory behavior", "Medium chain fatty acid biosynthetic process", "Medium chain fatty acid catabolic process", "Medium chain fatty acid metabolic process", "Medium chain fatty acyl coa metabolic process", "Megakaryocyte development", "Megakaryocyte differentiation", "Meiosis i cell cycle process", "Meiosis ii cell cycle process", "Meiotic cell cycle", "Meiotic cell cycle checkpoint signaling", "Meiotic cell cycle phase transition", "Meiotic cell cycle process", "Meiotic chromosome condensation", "Meiotic chromosome segregation", "Meiotic chromosome separation", "Meiotic cytokinesis", "Meiotic dna double strand break formation", "Meiotic sister chromatid cohesion centromeric", "Meiotic spindle assembly", "Meiotic spindle organization", "Membrane biogenesis", "Membrane depolarization", "Membrane depolarization during action potential", "Membrane depolarization during cardiac muscle cell action potential", "Membrane disassembly", "Membrane docking", "Membrane fission", "Membrane fusion", "Membrane hyperpolarization", "Membrane invagination", "Membrane lipid biosynthetic process", "Membrane lipid catabolic process", "Membrane lipid metabolic process", "Membrane organization", "Membrane protein ectodomain proteolysis", "Membrane protein intracellular domain proteolysis", "Membrane protein proteolysis", "Membrane raft assembly", "Membrane raft localization", "Membrane raft organization", "Membrane repolarization", "Membrane repolarization during action potential", "Membrane repolarization during atrial cardiac muscle cell action potential", "Membrane repolarization during cardiac muscle cell action potential", "Membrane to membrane docking", "Membranous septum morphogenesis", "Memory", "Mesenchymal cell development", "Mesenchymal cell differentiation", "Mesenchymal cell differentiation involved in kidney development", "Mesenchymal cell proliferation", "Mesenchymal cell proliferation involved in lung development", "Mesenchymal stem cell differentiation", "Mesenchymal stem cell proliferation", "Mesenchymal to epithelial transition", "Mesenchymal to epithelial transition involved in metanephros morphogenesis", "Mesenchyme development", "Mesenchyme morphogenesis", "Mesoderm development", "Mesoderm morphogenesis", "Mesodermal cell differentiation", "Mesonephric tubule morphogenesis", "Mesonephros development", "Metal ion export", "Metal ion homeostasis", "Metal ion transport", "Metanephric collecting duct development", "Metanephric epithelium development", "Metanephric mesenchymal cell differentiation", "Metanephric mesenchyme development", "Metanephric nephron development", "Metanephric nephron morphogenesis", "Metanephric nephron tubule epithelial cell differentiation", "Metanephric part of ureteric bud development", "Metanephric renal vesicle morphogenesis", "Metanephric tubule development", "Metanephros development", "Metanephros morphogenesis", "Metaphase anaphase transition of cell cycle", "Metaphase plate congression", "Metencephalon development", "Methionine biosynthetic process", "Methionine metabolic process", "Methylation", "Methylglyoxal metabolic process", "Methylguanosine cap decapping", "Mhc class i biosynthetic process", "Mhc class ii biosynthetic process", "Microglia differentiation", "Microglial cell activation", "Microglial cell proliferation", "Microtubule anchoring", "Microtubule anchoring at centrosome", "Microtubule anchoring at microtubule organizing center", "Microtubule based movement", "Microtubule based process", "Microtubule based transport", "Microtubule bundle formation", "Microtubule cytoskeleton organization", "Microtubule cytoskeleton organization involved in mitosis", "Microtubule depolymerization", "Microtubule nucleation", "Microtubule organizing center localization", "Microtubule organizing center organization", "Microtubule polymerization", "Microtubule polymerization or depolymerization", "Microvillus assembly", "Microvillus organization", "Midbody abscission", "Midbrain development", "Midbrain dopaminergic neuron differentiation", "Middle ear morphogenesis", "Minus end directed organelle transport along microtubule", "Mirna catabolic process", "Mirna loading onto risc involved in gene silencing by mirna", "Mirna metabolic process", "Mismatch repair", "Mitochondrial acetyl coa biosynthetic process from pyruvate", "Mitochondrial adp transmembrane transport", "Mitochondrial atp synthesis coupled proton transport", "Mitochondrial calcium ion homeostasis", "Mitochondrial calcium ion transmembrane transport", "Mitochondrial cytochrome c oxidase assembly", "Mitochondrial depolarization", "Mitochondrial dna metabolic process", "Mitochondrial dna repair", "Mitochondrial dna replication", "Mitochondrial electron transport cytochrome c to oxygen", "Mitochondrial electron transport nadh to ubiquinone", "Mitochondrial electron transport ubiquinol to cytochrome c", "Mitochondrial fission", "Mitochondrial fragmentation involved in apoptotic process", "Mitochondrial fusion", "Mitochondrial gene expression", "Mitochondrial genome maintenance", "Mitochondrial membrane organization", "Mitochondrial outer membrane permeabilization", "Mitochondrial outer membrane permeabilization involved in programmed cell death", "Mitochondrial protein catabolic process", "Mitochondrial protein processing", "Mitochondrial proton transporting atp synthase complex assembly", "Mitochondrial respirasome assembly", "Mitochondrial respiratory chain complex assembly", "Mitochondrial ribosome assembly", "Mitochondrial rna 3 end processing", "Mitochondrial rna catabolic process", "Mitochondrial rna metabolic process", "Mitochondrial rna modification", "Mitochondrial rna processing", "Mitochondrial transcription", "Mitochondrial translation", "Mitochondrial translational elongation", "Mitochondrial transmembrane transport", "Mitochondrial transport", "Mitochondrial trna processing", "Mitochondrion distribution", "Mitochondrion endoplasmic reticulum membrane tethering", "Mitochondrion localization", "Mitochondrion morphogenesis", "Mitochondrion organization", "Mitophagy", "Mitotic cell cycle", "Mitotic cell cycle checkpoint signaling", "Mitotic cell cycle phase transition", "Mitotic cell cycle process", "Mitotic chromosome condensation", "Mitotic cytokinesis", "Mitotic cytokinetic process", "Mitotic dna integrity checkpoint signaling", "Mitotic dna replication", "Mitotic dna replication checkpoint signaling", "Mitotic g1 s transition checkpoint signaling", "Mitotic g2 dna damage checkpoint signaling", "Mitotic g2 m transition checkpoint", "Mitotic intra s dna damage checkpoint signaling", "Mitotic metaphase plate congression", "Mitotic nuclear division", "Mitotic nuclear membrane disassembly", "Mitotic nuclear membrane organization", "Mitotic recombination", "Mitotic sister chromatid cohesion", "Mitotic sister chromatid segregation", "Mitotic spindle assembly", "Mitotic spindle midzone assembly", "Mitotic spindle organization", "Modification dependent macromolecule catabolic process", "Modification of postsynaptic actin cytoskeleton", "Modification of postsynaptic structure", "Modification of synaptic structure", "Modified amino acid transport", "Modulation by host of symbiont catalytic activity", "Modulation by host of symbiont process", "Modulation by host of viral genome replication", "Modulation by host of viral process", "Modulation of age related behavioral decline", "Modulation of excitatory postsynaptic potential", "Molting cycle", "Monoacylglycerol catabolic process", "Monoacylglycerol metabolic process", "Monoamine transport", "Monocarboxylic acid biosynthetic process", "Monocarboxylic acid catabolic process", "Monocarboxylic acid metabolic process", "Monocarboxylic acid transport", "Monocyte chemotaxis", "Monocyte differentiation", "Monocyte extravasation", "Mononuclear cell differentiation", "Mononuclear cell migration", "Monosaccharide biosynthetic process", "Monosaccharide catabolic process", "Monosaccharide metabolic process", "Monoubiquitinated protein deubiquitination", "Monovalent inorganic anion homeostasis", "Monovalent inorganic cation homeostasis", "Morphogenesis of a branching structure", "Morphogenesis of a polarized epithelium", "Morphogenesis of an endothelium", "Morphogenesis of an epithelial bud", "Morphogenesis of an epithelial fold", "Morphogenesis of an epithelial sheet", "Morphogenesis of an epithelium", "Morphogenesis of embryonic epithelium", "Motor behavior", "Motor learning", "Motor neuron apoptotic process", "Motor neuron axon guidance", "Mrna 3 end processing", "Mrna 3 end processing by stem loop binding and cleavage", "Mrna 3 splice site recognition", "Mrna 5 splice site recognition", "Mrna alternative polyadenylation", "Mrna catabolic process", "Mrna cis splicing via spliceosome", "Mrna cleavage", "Mrna cleavage involved in mrna processing", "Mrna destabilization mediated gene silencing", "Mrna export from nucleus", "Mrna metabolic process", "Mrna methylation", "Mrna modification", "Mrna processing", "Mrna pseudouridine synthesis", "Mrna splice site selection", "Mrna transcription", "Mrna transport", "Mucopolysaccharide metabolic process", "Multi multicellular organism process", "Multi organism reproductive process", "Multicellular organism aging", "Multicellular organism growth", "Multicellular organism reproduction", "Multicellular organismal homeostasis", "Multicellular organismal movement", "Multicellular organismal response to stress", "Multicellular organismal signaling", "Multivesicular body organization", "Multivesicular body sorting pathway", "Muscle adaptation", "Muscle cell apoptotic process", "Muscle cell cellular homeostasis", "Muscle cell development", "Muscle cell differentiation", "Muscle cell fate commitment", "Muscle cell migration", "Muscle cell proliferation", "Muscle contraction", "Muscle hypertrophy", "Muscle hypertrophy in response to stress", "Muscle organ development", "Muscle organ morphogenesis", "Muscle structure development", "Muscle system process", "Muscle tissue development", "Myd88 dependent toll like receptor signaling pathway", "Myelin assembly", "Myelin maintenance", "Myeloid cell activation involved in immune response", "Myeloid cell apoptotic process", "Myeloid cell development", "Myeloid cell differentiation", "Myeloid cell homeostasis", "Myeloid dendritic cell activation", "Myeloid dendritic cell cytokine production", "Myeloid dendritic cell differentiation", "Myeloid leukocyte activation", "Myeloid leukocyte cytokine production", "Myeloid leukocyte differentiation", "Myeloid leukocyte mediated immunity", "Myeloid leukocyte migration", "Myoblast differentiation", "Myoblast fusion", "Myoblast migration", "Myofibroblast differentiation", "Myosin filament organization", "Myotube cell development", "Myotube differentiation", "N acetylglucosamine metabolic process", "N acetylneuraminate catabolic process", "N acetylneuraminate metabolic process", "N acylethanolamine metabolic process", "N glycan processing", "N terminal peptidyl methionine acetylation", "N terminal protein amino acid acetylation", "N terminal protein amino acid modification", "N terminal protein lipidation", "Nad biosynthesis via nicotinamide riboside salvage pathway", "Nad metabolic process", "Nadh dehydrogenase complex assembly", "Nadh metabolic process", "Nadh oxidation", "Nadh regeneration", "Nadp metabolic process", "Nadph regeneration", "Natural killer cell activation", "Natural killer cell activation involved in immune response", "Natural killer cell degranulation", "Natural killer cell differentiation", "Natural killer cell mediated immunity", "Ncrna 3 end processing", "Ncrna catabolic process", "Ncrna export from nucleus", "Ncrna metabolic process", "Ncrna processing", "Ncrna transcription", "Necroptotic signaling pathway", "Necrotic cell death", "Negative chemotaxis", "Negative regulation by host of viral genome replication", "Negative regulation by host of viral process", "Negative regulation by host of viral transcription", "Negative regulation of actin filament bundle assembly", "Negative regulation of actin filament depolymerization", "Negative regulation of actin filament polymerization", "Negative regulation of actin nucleation", "Negative regulation of activated t cell proliferation", "Negative regulation of activin receptor signaling pathway", "Negative regulation of adaptive immune response", "Negative regulation of adenylate cyclase activating adrenergic receptor signaling pathway", "Negative regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Negative regulation of adenylate cyclase activity", "Negative regulation of alcohol biosynthetic process", "Negative regulation of alpha beta t cell activation", "Negative regulation of alpha beta t cell differentiation", "Negative regulation of alpha beta t cell proliferation", "Negative regulation of amine transport", "Negative regulation of amino acid transport", "Negative regulation of amyloid beta clearance", "Negative regulation of amyloid fibril formation", "Negative regulation of amyloid precursor protein biosynthetic process", "Negative regulation of amyloid precursor protein catabolic process", "Negative regulation of androgen receptor signaling pathway", "Negative regulation of anion transmembrane transport", "Negative regulation of anion transport", "Negative regulation of anoikis", "Negative regulation of antigen receptor mediated signaling pathway", "Negative regulation of apoptotic signaling pathway", "Negative regulation of arp2 3 complex mediated actin nucleation", "Negative regulation of astrocyte differentiation", "Negative regulation of atp biosynthetic process", "Negative regulation of atp dependent activity", "Negative regulation of atp metabolic process", "Negative regulation of autophagosome assembly", "Negative regulation of autophagosome maturation", "Negative regulation of autophagy", "Negative regulation of autophagy of mitochondrion", "Negative regulation of axon extension", "Negative regulation of axonogenesis", "Negative regulation of b cell activation", "Negative regulation of b cell apoptotic process", "Negative regulation of b cell differentiation", "Negative regulation of b cell mediated immunity", "Negative regulation of b cell proliferation", "Negative regulation of behavior", "Negative regulation of bicellular tight junction assembly", "Negative regulation of binding", "Negative regulation of biomineralization", "Negative regulation of biosynthetic process", "Negative regulation of blood circulation", "Negative regulation of blood pressure", "Negative regulation of blood vessel endothelial cell migration", "Negative regulation of bmp signaling pathway", "Negative regulation of bone mineralization", "Negative regulation of bone remodeling", "Negative regulation of calcineurin mediated signaling", "Negative regulation of calcium ion dependent exocytosis", "Negative regulation of calcium ion import", "Negative regulation of calcium ion transmembrane transport", "Negative regulation of calcium ion transport", "Negative regulation of calcium ion transport into cytosol", "Negative regulation of calcium mediated signaling", "Negative regulation of camp dependent protein kinase activity", "Negative regulation of canonical wnt signaling pathway", "Negative regulation of carbohydrate metabolic process", "Negative regulation of cardiac muscle adaptation", "Negative regulation of cardiac muscle contraction", "Negative regulation of cardiac muscle tissue growth", "Negative regulation of cartilage development", "Negative regulation of catabolic process", "Negative regulation of catalytic activity", "Negative regulation of cation channel activity", "Negative regulation of cd4 positive alpha beta t cell activation", "Negative regulation of cd4 positive alpha beta t cell differentiation", "Negative regulation of cd4 positive alpha beta t cell proliferation", "Negative regulation of cell activation", "Negative regulation of cell adhesion", "Negative regulation of cell adhesion mediated by integrin", "Negative regulation of cell aging", "Negative regulation of cell cell adhesion", "Negative regulation of cell cell adhesion mediated by cadherin", "Negative regulation of cell cycle", "Negative regulation of cell cycle checkpoint", "Negative regulation of cell cycle g1 s phase transition", "Negative regulation of cell cycle g2 m phase transition", "Negative regulation of cell cycle phase transition", "Negative regulation of cell cycle process", "Negative regulation of cell death", "Negative regulation of cell development", "Negative regulation of cell differentiation", "Negative regulation of cell division", "Negative regulation of cell growth", "Negative regulation of cell growth involved in cardiac muscle cell development", "Negative regulation of cell junction assembly", "Negative regulation of cell killing", "Negative regulation of cell matrix adhesion", "Negative regulation of cell morphogenesis involved in differentiation", "Negative regulation of cell population proliferation", "Negative regulation of cell projection organization", "Negative regulation of cell size", "Negative regulation of cell substrate adhesion", "Negative regulation of cell substrate junction organization", "Negative regulation of cell volume", "Negative regulation of cellular amide metabolic process", "Negative regulation of cellular catabolic process", "Negative regulation of cellular component organization", "Negative regulation of cellular macromolecule biosynthetic process", "Negative regulation of cellular protein catabolic process", "Negative regulation of cellular respiration", "Negative regulation of cellular response to growth factor stimulus", "Negative regulation of cellular response to hypoxia", "Negative regulation of cellular response to insulin stimulus", "Negative regulation of cellular senescence", "Negative regulation of centriole replication", "Negative regulation of centrosome duplication", "Negative regulation of ceramide biosynthetic process", "Negative regulation of chemokine c c motif ligand 5 production", "Negative regulation of chemokine mediated signaling pathway", "Negative regulation of chemokine production", "Negative regulation of chemotaxis", "Negative regulation of cholesterol metabolic process", "Negative regulation of chondrocyte differentiation", "Negative regulation of chromatin binding", "Negative regulation of chromosome organization", "Negative regulation of cilium assembly", "Negative regulation of circadian rhythm", "Negative regulation of cold induced thermogenesis", "Negative regulation of collateral sprouting", "Negative regulation of cyclic nucleotide phosphodiesterase activity", "Negative regulation of cyclin dependent protein serine threonine kinase activity", "Negative regulation of cysteine type endopeptidase activity", "Negative regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Negative regulation of cytokine production", "Negative regulation of cytokine production involved in immune response", "Negative regulation of cytokine production involved in inflammatory response", "Negative regulation of cytokinesis", "Negative regulation of cytoplasmic translation", "Negative regulation of cytoskeleton organization", "Negative regulation of cytosolic calcium ion concentration", "Negative regulation of defense response", "Negative regulation of defense response to bacterium", "Negative regulation of defense response to virus", "Negative regulation of delayed rectifier potassium channel activity", "Negative regulation of dendrite development", "Negative regulation of dendrite morphogenesis", "Negative regulation of dendritic spine development", "Negative regulation of dendritic spine morphogenesis", "Negative regulation of dephosphorylation", "Negative regulation of developmental growth", "Negative regulation of developmental process", "Negative regulation of digestive system process", "Negative regulation of dna binding", "Negative regulation of dna binding transcription factor activity", "Negative regulation of dna biosynthetic process", "Negative regulation of dna damage checkpoint", "Negative regulation of dna damage response signal transduction by p53 class mediator", "Negative regulation of dna dependent dna replication", "Negative regulation of dna metabolic process", "Negative regulation of dna recombination", "Negative regulation of dna repair", "Negative regulation of dna replication", "Negative regulation of dna templated transcription elongation", "Negative regulation of dna templated transcription initiation", "Negative regulation of double strand break repair via homologous recombination", "Negative regulation of double strand break repair via nonhomologous end joining", "Negative regulation of endocytosis", "Negative regulation of endoplasmic reticulum calcium ion concentration", "Negative regulation of endoplasmic reticulum stress induced eif2 alpha phosphorylation", "Negative regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Negative regulation of endoplasmic reticulum unfolded protein response", "Negative regulation of endothelial cell proliferation", "Negative regulation of epidermal growth factor activated receptor activity", "Negative regulation of epidermis development", "Negative regulation of epithelial cell apoptotic process", "Negative regulation of epithelial cell differentiation", "Negative regulation of epithelial cell migration", "Negative regulation of epithelial cell proliferation", "Negative regulation of erad pathway", "Negative regulation of erbb signaling pathway", "Negative regulation of erk1 and erk2 cascade", "Negative regulation of erythrocyte differentiation", "Negative regulation of establishment of protein localization", "Negative regulation of establishment of protein localization to mitochondrion", "Negative regulation of excitatory postsynaptic potential", "Negative regulation of execution phase of apoptosis", "Negative regulation of exocytosis", "Negative regulation of extrinsic apoptotic signaling pathway", "Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Negative regulation of fat cell differentiation", "Negative regulation of fatty acid beta oxidation", "Negative regulation of fatty acid biosynthetic process", "Negative regulation of fatty acid metabolic process", "Negative regulation of fatty acid oxidation", "Negative regulation of fatty acid transport", "Negative regulation of feeding behavior", "Negative regulation of fibroblast apoptotic process", "Negative regulation of fibroblast migration", "Negative regulation of fibroblast proliferation", "Negative regulation of filopodium assembly", "Negative regulation of g protein coupled receptor signaling pathway", "Negative regulation of gene expression", "Negative regulation of gene expression epigenetic", "Negative regulation of glial cell differentiation", "Negative regulation of glial cell proliferation", "Negative regulation of gliogenesis", "Negative regulation of glucocorticoid metabolic process", "Negative regulation of gluconeogenesis", "Negative regulation of glucose import", "Negative regulation of glucose transmembrane transport", "Negative regulation of glycolytic process", "Negative regulation of glycoprotein metabolic process", "Negative regulation of golgi to plasma membrane protein transport", "Negative regulation of granulocyte chemotaxis", "Negative regulation of growth", "Negative regulation of gtpase activity", "Negative regulation of guanyl nucleotide exchange factor activity", "Negative regulation of heart rate", "Negative regulation of helicase activity", "Negative regulation of hematopoietic progenitor cell differentiation", "Negative regulation of hemopoiesis", "Negative regulation of hepatocyte apoptotic process", "Negative regulation of hippo signaling", "Negative regulation of histone acetylation", "Negative regulation of histone deacetylation", "Negative regulation of histone h3 k27 methylation", "Negative regulation of histone h3 k4 methylation", "Negative regulation of histone h3 k9 methylation", "Negative regulation of histone h3 k9 trimethylation", "Negative regulation of histone h4 acetylation", "Negative regulation of histone methylation", "Negative regulation of histone modification", "Negative regulation of histone phosphorylation", "Negative regulation of homotypic cell cell adhesion", "Negative regulation of hormone biosynthetic process", "Negative regulation of hormone metabolic process", "Negative regulation of hormone secretion", "Negative regulation of hydrogen peroxide mediated programmed cell death", "Negative regulation of hydrolase activity", "Negative regulation of hypoxia induced intrinsic apoptotic signaling pathway", "Negative regulation of i kappab kinase nf kappab signaling", "Negative regulation of immune effector process", "Negative regulation of immune response", "Negative regulation of immune system process", "Negative regulation of immunoglobulin production", "Negative regulation of inclusion body assembly", "Negative regulation of inflammatory response", "Negative regulation of inflammatory response to antigenic stimulus", "Negative regulation of innate immune response", "Negative regulation of insulin secretion involved in cellular response to glucose stimulus", "Negative regulation of interferon gamma production", "Negative regulation of interleukin 12 production", "Negative regulation of interleukin 13 production", "Negative regulation of interleukin 17 production", "Negative regulation of interleukin 2 production", "Negative regulation of interleukin 6 production", "Negative regulation of interleukin 8 production", "Negative regulation of intracellular estrogen receptor signaling pathway", "Negative regulation of intracellular protein transport", "Negative regulation of intracellular signal transduction", "Negative regulation of intracellular steroid hormone receptor signaling pathway", "Negative regulation of intracellular transport", "Negative regulation of intrinsic apoptotic signaling pathway", "Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Negative regulation of ion transmembrane transport", "Negative regulation of ion transmembrane transporter activity", "Negative regulation of ion transport", "Negative regulation of ire1 mediated unfolded protein response", "Negative regulation of isotype switching", "Negative regulation of jnk cascade", "Negative regulation of jun kinase activity", "Negative regulation of keratinocyte differentiation", "Negative regulation of keratinocyte proliferation", "Negative regulation of kidney development", "Negative regulation of kinase activity", "Negative regulation of lamellipodium assembly", "Negative regulation of lamellipodium organization", "Negative regulation of leukocyte apoptotic process", "Negative regulation of leukocyte cell cell adhesion", "Negative regulation of leukocyte chemotaxis", "Negative regulation of leukocyte degranulation", "Negative regulation of leukocyte mediated immunity", "Negative regulation of leukocyte migration", "Negative regulation of leukocyte proliferation", "Negative regulation of lipase activity", "Negative regulation of lipid biosynthetic process", "Negative regulation of lipid catabolic process", "Negative regulation of lipid localization", "Negative regulation of lipid metabolic process", "Negative regulation of lipid storage", "Negative regulation of lipid transport", "Negative regulation of lipopolysaccharide mediated signaling pathway", "Negative regulation of lipoprotein lipase activity", "Negative regulation of lipoprotein particle clearance", "Negative regulation of locomotion", "Negative regulation of low density lipoprotein particle clearance", "Negative regulation of lyase activity", "Negative regulation of lymphocyte activation", "Negative regulation of lymphocyte apoptotic process", "Negative regulation of lymphocyte differentiation", "Negative regulation of lymphocyte mediated immunity", "Negative regulation of lymphocyte migration", "Negative regulation of macroautophagy", "Negative regulation of macrophage chemotaxis", "Negative regulation of macrophage migration", "Negative regulation of map kinase activity", "Negative regulation of mapk cascade", "Negative regulation of mast cell activation", "Negative regulation of mast cell activation involved in immune response", "Negative regulation of mast cell degranulation", "Negative regulation of megakaryocyte differentiation", "Negative regulation of meiotic cell cycle", "Negative regulation of meiotic nuclear division", "Negative regulation of membrane permeability", "Negative regulation of membrane potential", "Negative regulation of membrane protein ectodomain proteolysis", "Negative regulation of mesenchymal cell proliferation", "Negative regulation of metalloendopeptidase activity", "Negative regulation of metallopeptidase activity", "Negative regulation of metaphase anaphase transition of cell cycle", "Negative regulation of mhc class ii biosynthetic process", "Negative regulation of microtubule polymerization", "Negative regulation of microtubule polymerization or depolymerization", "Negative regulation of mirna transcription", "Negative regulation of mitochondrial fusion", "Negative regulation of mitochondrial membrane permeability", "Negative regulation of mitochondrial membrane permeability involved in apoptotic process", "Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Negative regulation of mitochondrion organization", "Negative regulation of mitophagy", "Negative regulation of mitotic cell cycle", "Negative regulation of mitotic cell cycle phase transition", "Negative regulation of molecular function", "Negative regulation of monocyte chemotaxis", "Negative regulation of mononuclear cell migration", "Negative regulation of monooxygenase activity", "Negative regulation of mrna 3 end processing", "Negative regulation of mrna catabolic process", "Negative regulation of mrna metabolic process", "Negative regulation of mrna processing", "Negative regulation of mrna splicing via spliceosome", "Negative regulation of multicellular organismal process", "Negative regulation of muscle adaptation", "Negative regulation of muscle cell apoptotic process", "Negative regulation of muscle cell differentiation", "Negative regulation of muscle contraction", "Negative regulation of muscle hypertrophy", "Negative regulation of muscle organ development", "Negative regulation of muscle tissue development", "Negative regulation of myelination", "Negative regulation of myeloid cell apoptotic process", "Negative regulation of myeloid cell differentiation", "Negative regulation of myeloid leukocyte differentiation", "Negative regulation of myeloid leukocyte mediated immunity", "Negative regulation of myoblast differentiation", "Negative regulation of myosin light chain phosphatase activity", "Negative regulation of myotube differentiation", "Negative regulation of natural killer cell activation", "Negative regulation of natural killer cell mediated immunity", "Negative regulation of necrotic cell death", "Negative regulation of nervous system development", "Negative regulation of nervous system process", "Negative regulation of neural precursor cell proliferation", "Negative regulation of neuroblast proliferation", "Negative regulation of neuron apoptotic process", "Negative regulation of neuron death", "Negative regulation of neuron differentiation", "Negative regulation of neuron migration", "Negative regulation of neuron projection development", "Negative regulation of neuron projection regeneration", "Negative regulation of neurotransmitter secretion", "Negative regulation of neurotransmitter transport", "Negative regulation of neutrophil migration", "Negative regulation of nf kappab transcription factor activity", "Negative regulation of nik nf kappab signaling", "Negative regulation of nitric oxide metabolic process", "Negative regulation of nitric oxide synthase activity", "Negative regulation of nlrp3 inflammasome complex assembly", "Negative regulation of notch signaling pathway", "Negative regulation of nuclear division", "Negative regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Negative regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Negative regulation of nuclease activity", "Negative regulation of nucleobase containing compound metabolic process", "Negative regulation of nucleocytoplasmic transport", "Negative regulation of nucleotide biosynthetic process", "Negative regulation of nucleotide metabolic process", "Negative regulation of oligodendrocyte differentiation", "Negative regulation of organ growth", "Negative regulation of organelle assembly", "Negative regulation of organelle organization", "Negative regulation of organic acid transport", "Negative regulation of ossification", "Negative regulation of osteoblast proliferation", "Negative regulation of osteoclast differentiation", "Negative regulation of oxidative phosphorylation", "Negative regulation of oxidative stress induced cell death", "Negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Negative regulation of oxidative stress induced neuron death", "Negative regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway", "Negative regulation of oxidoreductase activity", "Negative regulation of p38mapk cascade", "Negative regulation of pathway restricted smad protein phosphorylation", "Negative regulation of peptidase activity", "Negative regulation of peptide secretion", "Negative regulation of peptidyl lysine acetylation", "Negative regulation of peptidyl serine phosphorylation", "Negative regulation of peptidyl threonine phosphorylation", "Negative regulation of peptidyl tyrosine phosphorylation", "Negative regulation of perk mediated unfolded protein response", "Negative regulation of phagocytosis", "Negative regulation of phosphatase activity", "Negative regulation of phosphatidylinositol 3 kinase signaling", "Negative regulation of phospholipase activity", "Negative regulation of phospholipid metabolic process", "Negative regulation of phosphoprotein phosphatase activity", "Negative regulation of phosphorus metabolic process", "Negative regulation of phosphorylation", "Negative regulation of plasma membrane bounded cell projection assembly", "Negative regulation of platelet derived growth factor receptor signaling pathway", "Negative regulation of posttranscriptional gene silencing", "Negative regulation of potassium ion transmembrane transport", "Negative regulation of potassium ion transport", "Negative regulation of production of mirnas involved in gene silencing by mirna", "Negative regulation of production of molecular mediator of immune response", "Negative regulation of programmed necrotic cell death", "Negative regulation of prostaglandin biosynthetic process", "Negative regulation of proteasomal protein catabolic process", "Negative regulation of proteasomal ubiquitin dependent protein catabolic process", "Negative regulation of protein acetylation", "Negative regulation of protein autophosphorylation", "Negative regulation of protein binding", "Negative regulation of protein catabolic process", "Negative regulation of protein containing complex assembly", "Negative regulation of protein containing complex disassembly", "Negative regulation of protein dephosphorylation", "Negative regulation of protein exit from endoplasmic reticulum", "Negative regulation of protein export from nucleus", "Negative regulation of protein import into nucleus", "Negative regulation of protein k63 linked ubiquitination", "Negative regulation of protein kinase activity by regulation of protein phosphorylation", "Negative regulation of protein kinase b signaling", "Negative regulation of protein localization", "Negative regulation of protein localization to cell periphery", "Negative regulation of protein localization to cell surface", "Negative regulation of protein localization to membrane", "Negative regulation of protein localization to nucleus", "Negative regulation of protein maturation", "Negative regulation of protein metabolic process", "Negative regulation of protein modification by small protein conjugation or removal", "Negative regulation of protein modification process", "Negative regulation of protein polymerization", "Negative regulation of protein polyubiquitination", "Negative regulation of protein secretion", "Negative regulation of protein serine threonine kinase activity", "Negative regulation of protein sumoylation", "Negative regulation of protein targeting to membrane", "Negative regulation of protein targeting to mitochondrion", "Negative regulation of protein tyrosine kinase activity", "Negative regulation of proteolysis", "Negative regulation of proteolysis involved in cellular protein catabolic process", "Negative regulation of reactive oxygen species biosynthetic process", "Negative regulation of reactive oxygen species metabolic process", "Negative regulation of receptor binding", "Negative regulation of receptor internalization", "Negative regulation of receptor mediated endocytosis", "Negative regulation of receptor signaling pathway via jak stat", "Negative regulation of receptor signaling pathway via stat", "Negative regulation of regulated secretory pathway", "Negative regulation of release of cytochrome c from mitochondria", "Negative regulation of reproductive process", "Negative regulation of respiratory burst", "Negative regulation of respiratory burst involved in inflammatory response", "Negative regulation of response to biotic stimulus", "Negative regulation of response to cytokine stimulus", "Negative regulation of response to dna damage stimulus", "Negative regulation of response to endoplasmic reticulum stress", "Negative regulation of response to external stimulus", "Negative regulation of response to food", "Negative regulation of response to oxidative stress", "Negative regulation of response to reactive oxygen species", "Negative regulation of response to stimulus", "Negative regulation of response to wounding", "Negative regulation of retinoic acid receptor signaling pathway", "Negative regulation of rho protein signal transduction", "Negative regulation of rig i signaling pathway", "Negative regulation of rna catabolic process", "Negative regulation of rna splicing", "Negative regulation of ruffle assembly", "Negative regulation of ryanodine sensitive calcium release channel activity", "Negative regulation of schwann cell proliferation", "Negative regulation of secondary metabolite biosynthetic process", "Negative regulation of secretion", "Negative regulation of sequestering of triglyceride", "Negative regulation of signal transduction by p53 class mediator", "Negative regulation of signal transduction in absence of ligand", "Negative regulation of signaling", "Negative regulation of signaling receptor activity", "Negative regulation of single stranded viral rna replication via double stranded dna intermediate", "Negative regulation of sister chromatid cohesion", "Negative regulation of smad protein signal transduction", "Negative regulation of small gtpase mediated signal transduction", "Negative regulation of small molecule metabolic process", "Negative regulation of smooth muscle cell apoptotic process", "Negative regulation of smooth muscle cell differentiation", "Negative regulation of smooth muscle cell migration", "Negative regulation of smooth muscle cell proliferation", "Negative regulation of smoothened signaling pathway", "Negative regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Negative regulation of sodium ion transmembrane transport", "Negative regulation of sodium ion transport", "Negative regulation of sphingolipid biosynthetic process", "Negative regulation of stem cell differentiation", "Negative regulation of steroid metabolic process", "Negative regulation of stress activated protein kinase signaling cascade", "Negative regulation of striated muscle cell apoptotic process", "Negative regulation of striated muscle cell differentiation", "Negative regulation of striated muscle contraction", "Negative regulation of supramolecular fiber organization", "Negative regulation of synapse organization", "Negative regulation of synaptic transmission", "Negative regulation of synaptic transmission glutamatergic", "Negative regulation of synaptic vesicle exocytosis", "Negative regulation of systemic arterial blood pressure", "Negative regulation of t cell apoptotic process", "Negative regulation of t cell differentiation", "Negative regulation of t cell proliferation", "Negative regulation of t cell receptor signaling pathway", "Negative regulation of t helper cell differentiation", "Negative regulation of telomerase activity", "Negative regulation of telomere capping", "Negative regulation of telomere maintenance", "Negative regulation of telomere maintenance via telomerase", "Negative regulation of telomere maintenance via telomere lengthening", "Negative regulation of tissue remodeling", "Negative regulation of toll like receptor signaling pathway", "Negative regulation of tor signaling", "Negative regulation of transcription by competitive promoter binding", "Negative regulation of transcription by rna polymerase i", "Negative regulation of transcription by rna polymerase ii", "Negative regulation of transcription from rna polymerase ii promoter in response to stress", "Negative regulation of transcription initiation from rna polymerase ii promoter", "Negative regulation of transcription regulatory region dna binding", "Negative regulation of transferase activity", "Negative regulation of transforming growth factor beta production", "Negative regulation of transforming growth factor beta receptor signaling pathway", "Negative regulation of transforming growth factor beta1 production", "Negative regulation of translational elongation", "Negative regulation of translational initiation", "Negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Negative regulation of transmembrane transport", "Negative regulation of transport", "Negative regulation of transporter activity", "Negative regulation of trophoblast cell migration", "Negative regulation of tubulin deacetylation", "Negative regulation of tumor necrosis factor superfamily cytokine production", "Negative regulation of type 2 immune response", "Negative regulation of type b pancreatic cell apoptotic process", "Negative regulation of type i interferon mediated signaling pathway", "Negative regulation of type i interferon production", "Negative regulation of tyrosine phosphorylation of stat protein", "Negative regulation of ubiquitin dependent protein catabolic process", "Negative regulation of ubiquitin protein ligase activity", "Negative regulation of ubiquitin protein transferase activity", "Negative regulation of vascular associated smooth muscle cell apoptotic process", "Negative regulation of vascular associated smooth muscle cell differentiation", "Negative regulation of vascular associated smooth muscle cell migration", "Negative regulation of vascular associated smooth muscle cell proliferation", "Negative regulation of vascular endothelial growth factor production", "Negative regulation of vascular endothelial growth factor receptor signaling pathway", "Negative regulation of vascular permeability", "Negative regulation of vascular wound healing", "Negative regulation of vasculature development", "Negative regulation of viral entry into host cell", "Negative regulation of viral genome replication", "Negative regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Negative regulation of viral life cycle", "Negative regulation of viral process", "Negative regulation of viral transcription", "Negative regulation of vitamin metabolic process", "Negative regulation of voltage gated calcium channel activity", "Negative regulation of voltage gated potassium channel activity", "Negative regulation of wnt signaling pathway", "Negative regulation of wound healing", "Nephron development", "Nephron epithelium development", "Nephron morphogenesis", "Nephron tubule epithelial cell differentiation", "Nephron tubule formation", "Nerve development", "Nerve growth factor signaling pathway", "Nervous system process", "Nervous system process involved in regulation of systemic arterial blood pressure", "Netrin activated signaling pathway", "Neural crest cell differentiation", "Neural crest cell migration", "Neural crest formation", "Neural nucleus development", "Neural plate development", "Neural plate morphogenesis", "Neural precursor cell proliferation", "Neural retina development", "Neural tube development", "Neural tube formation", "Neural tube patterning", "Neuroblast division", "Neuroblast proliferation", "Neuroendocrine cell differentiation", "Neuroepithelial cell differentiation", "Neurogenesis", "Neuroinflammatory response", "Neuromuscular junction development", "Neuromuscular process", "Neuromuscular process controlling balance", "Neuromuscular process controlling posture", "Neuromuscular synaptic transmission", "Neuron apoptotic process", "Neuron cellular homeostasis", "Neuron death", "Neuron death in response to hydrogen peroxide", "Neuron death in response to oxidative stress", "Neuron development", "Neuron differentiation", "Neuron fate commitment", "Neuron fate determination", "Neuron intrinsic apoptotic signaling pathway in response to oxidative stress", "Neuron maturation", "Neuron migration", "Neuron neuron synaptic transmission", "Neuron projection arborization", "Neuron projection extension", "Neuron projection extension involved in neuron projection guidance", "Neuron projection guidance", "Neuron projection maintenance", "Neuron projection organization", "Neuron projection regeneration", "Neuron recognition", "Neuron remodeling", "Neuronal action potential", "Neuronal ion channel clustering", "Neuronal stem cell population maintenance", "Neuropeptide signaling pathway", "Neurotransmitter biosynthetic process", "Neurotransmitter catabolic process", "Neurotransmitter gated ion channel clustering", "Neurotransmitter metabolic process", "Neurotransmitter receptor internalization", "Neurotransmitter receptor localization to postsynaptic specialization membrane", "Neurotransmitter receptor transport", "Neurotransmitter receptor transport endosome to postsynaptic membrane", "Neurotransmitter receptor transport postsynaptic endosome to lysosome", "Neurotransmitter receptor transport to plasma membrane", "Neurotransmitter reuptake", "Neurotransmitter secretion", "Neurotransmitter transport", "Neurotransmitter uptake", "Neurotrophin production", "Neurotrophin signaling pathway", "Neurotrophin trk receptor signaling pathway", "Neutral amino acid transport", "Neutral lipid biosynthetic process", "Neutral lipid catabolic process", "Neutral lipid metabolic process", "Neutrophil activation involved in immune response", "Neutrophil apoptotic process", "Neutrophil chemotaxis", "Neutrophil clearance", "Neutrophil degranulation", "Neutrophil differentiation", "Neutrophil homeostasis", "Neutrophil mediated immunity", "Neutrophil migration", "Nik nf kappab signaling", "Nitric oxide mediated signal transduction", "Nitric oxide synthase biosynthetic process", "Nitrogen compound transport", "Nk t cell activation", "Nk t cell differentiation", "Nls bearing protein import into nucleus", "Non canonical wnt signaling pathway", "Non lytic viral release", "Non membrane bounded organelle assembly", "Non motile cilium assembly", "Nonribosomal peptide biosynthetic process", "Nose development", "Notch receptor processing", "Notch signaling involved in heart development", "Notch signaling pathway", "Nuclear body organization", "Nuclear chromosome segregation", "Nuclear envelope organization", "Nuclear export", "Nuclear membrane organization", "Nuclear membrane reassembly", "Nuclear migration", "Nuclear ncrna surveillance", "Nuclear pore complex assembly", "Nuclear pore organization", "Nuclear transcribed mrna catabolic process", "Nuclear transcribed mrna catabolic process deadenylation dependent decay", "Nuclear transcribed mrna catabolic process deadenylation independent decay", "Nuclear transcribed mrna catabolic process exonucleolytic", "Nuclear transcribed mrna catabolic process exonucleolytic 3 5", "Nuclear transcribed mrna catabolic process nonsense mediated decay", "Nuclear transcribed mrna poly a tail shortening", "Nuclear transport", "Nucleic acid phosphodiester bond hydrolysis", "Nucleobase biosynthetic process", "Nucleobase catabolic process", "Nucleobase containing compound transport", "Nucleobase containing small molecule biosynthetic process", "Nucleobase containing small molecule catabolic process", "Nucleobase containing small molecule interconversion", "Nucleobase containing small molecule metabolic process", "Nucleobase metabolic process", "Nucleobase transport", "Nucleolar chromatin organization", "Nucleolar large rrna transcription by rna polymerase i", "Nucleolus organization", "Nucleoside bisphosphate biosynthetic process", "Nucleoside bisphosphate catabolic process", "Nucleoside bisphosphate metabolic process", "Nucleoside catabolic process", "Nucleoside diphosphate biosynthetic process", "Nucleoside diphosphate catabolic process", "Nucleoside diphosphate metabolic process", "Nucleoside metabolic process", "Nucleoside monophosphate biosynthetic process", "Nucleoside monophosphate catabolic process", "Nucleoside monophosphate metabolic process", "Nucleoside monophosphate phosphorylation", "Nucleoside phosphate biosynthetic process", "Nucleoside phosphate catabolic process", "Nucleoside salvage", "Nucleoside triphosphate biosynthetic process", "Nucleoside triphosphate catabolic process", "Nucleoside triphosphate metabolic process", "Nucleosome assembly", "Nucleosome mobilization", "Nucleosome organization", "Nucleosome positioning", "Nucleotide binding domain leucine rich repeat containing receptor signaling pathway", "Nucleotide binding oligomerization domain containing 2 signaling pathway", "Nucleotide excision repair", "Nucleotide excision repair dna gap filling", "Nucleotide excision repair dna incision", "Nucleotide phosphorylation", "Nucleotide salvage", "Nucleotide sugar biosynthetic process", "Nucleotide sugar metabolic process", "Nucleotide sugar transmembrane transport", "Nucleotide transmembrane transport", "Nucleotide transport", "Nucleus localization", "Nucleus organization", "O glycan processing", "Observational learning", "Odontoblast differentiation", "Odontogenesis", "Odontogenesis of dentin containing tooth", "Olefinic compound biosynthetic process", "Olefinic compound metabolic process", "Olfactory behavior", "Olfactory bulb interneuron development", "Olfactory bulb interneuron differentiation", "Olfactory lobe development", "Olfactory nerve development", "Oligodendrocyte development", "Oligodendrocyte differentiation", "Oligodendrocyte progenitor proliferation", "Oligopeptide transport", "Oligosaccharide biosynthetic process", "Oligosaccharide catabolic process", "Oligosaccharide lipid intermediate biosynthetic process", "Oligosaccharide metabolic process", "One carbon metabolic process", "Oocyte construction", "Oocyte differentiation", "Oocyte maturation", "Oogenesis", "Optic nerve development", "Organ growth", "Organ induction", "Organ or tissue specific immune response", "Organelle assembly", "Organelle disassembly", "Organelle fission", "Organelle fusion", "Organelle inheritance", "Organelle localization", "Organelle membrane fusion", "Organelle transport along microtubule", "Organic acid biosynthetic process", "Organic acid catabolic process", "Organic acid metabolic process", "Organic acid transmembrane transport", "Organic acid transport", "Organic anion transport", "Organic cation transport", "Organic cyclic compound catabolic process", "Organic hydroxy compound biosynthetic process", "Organic hydroxy compound catabolic process", "Organic hydroxy compound metabolic process", "Organic hydroxy compound transport", "Organism emergence from protective structure", "Organonitrogen compound biosynthetic process", "Organonitrogen compound catabolic process", "Organophosphate biosynthetic process", "Organophosphate catabolic process", "Organophosphate ester transport", "Organophosphate metabolic process", "Ornithine metabolic process", "Ornithine transport", "Ossification", "Osteoblast differentiation", "Osteoblast proliferation", "Osteoclast development", "Osteoclast differentiation", "Outer dynein arm assembly", "Outer ear morphogenesis", "Outer mitochondrial membrane organization", "Outflow tract morphogenesis", "Ovarian follicle development", "Oviduct development", "Ovulation", "Ovulation cycle", "Ovulation cycle process", "Ovulation from ovarian follicle", "Oxaloacetate metabolic process", "Oxaloacetate transport", "Oxidative demethylation", "Oxidative dna demethylation", "Oxidative phosphorylation", "Oxidative rna demethylation", "Oxygen homeostasis", "P body assembly", "P38mapk cascade", "Pallium development", "Pancreas development", "Pancreatic juice secretion", "Pantothenate metabolic process", "Parallel actin filament bundle assembly", "Paranodal junction assembly", "Parathyroid gland development", "Paraxial mesoderm development", "Parkin mediated stimulation of mitophagy in response to mitochondrial depolarization", "Pathway restricted smad protein phosphorylation", "Pattern recognition receptor signaling pathway", "Pattern specification process", "Penetration of zona pellucida", "Pentose catabolic process", "Pentose metabolic process", "Pentose phosphate shunt", "Pentose phosphate shunt non oxidative branch", "Peptide antigen assembly with mhc protein complex", "Peptide biosynthetic process", "Peptide catabolic process", "Peptide cross linking", "Peptide metabolic process", "Peptide modification", "Peptide transport", "Peptidyl amino acid modification", "Peptidyl arginine methylation", "Peptidyl arginine methylation to asymmetrical dimethyl arginine", "Peptidyl arginine modification", "Peptidyl arginine n methylation", "Peptidyl asparagine modification", "Peptidyl cysteine modification", "Peptidyl diphthamide biosynthetic process from peptidyl histidine", "Peptidyl glutamic acid modification", "Peptidyl glutamine methylation", "Peptidyl histidine modification", "Peptidyl lysine acetylation", "Peptidyl lysine deacetylation", "Peptidyl lysine dimethylation", "Peptidyl lysine hydroxylation", "Peptidyl lysine methylation", "Peptidyl lysine modification", "Peptidyl lysine monomethylation", "Peptidyl lysine trimethylation", "Peptidyl methionine modification", "Peptidyl proline hydroxylation", "Peptidyl proline hydroxylation to 4 hydroxy l proline", "Peptidyl proline modification", "Peptidyl serine autophosphorylation", "Peptidyl serine dephosphorylation", "Peptidyl serine modification", "Peptidyl threonine dephosphorylation", "Peptidyl threonine modification", "Peptidyl tyrosine autophosphorylation", "Peptidyl tyrosine dephosphorylation", "Peptidyl tyrosine dephosphorylation involved in inactivation of protein kinase activity", "Peptidyl tyrosine modification", "Pericardium development", "Peripheral nervous system axon regeneration", "Peripheral nervous system development", "Peripheral nervous system myelin maintenance", "Perk mediated unfolded protein response", "Peroxisomal transport", "Peroxisome fission", "Peroxisome organization", "Peroxisome proliferator activated receptor signaling pathway", "Ph reduction", "Phagocytosis", "Phagocytosis recognition", "Phagolysosome assembly", "Phagosome acidification", "Phagosome lysosome fusion", "Phagosome maturation", "Pharyngeal system development", "Phenol containing compound biosynthetic process", "Phenol containing compound catabolic process", "Phenol containing compound metabolic process", "Phenotypic switching", "Phosphagen metabolic process", "Phosphate ion transmembrane transport", "Phosphate ion transport", "Phosphatidic acid metabolic process", "Phosphatidylcholine acyl chain remodeling", "Phosphatidylcholine biosynthetic process", "Phosphatidylcholine catabolic process", "Phosphatidylcholine metabolic process", "Phosphatidylethanolamine biosynthetic process", "Phosphatidylethanolamine metabolic process", "Phosphatidylglycerol acyl chain remodeling", "Phosphatidylglycerol biosynthetic process", "Phosphatidylglycerol metabolic process", "Phosphatidylinositol 3 kinase signaling", "Phosphatidylinositol 3 phosphate biosynthetic process", "Phosphatidylinositol acyl chain remodeling", "Phosphatidylinositol biosynthetic process", "Phosphatidylinositol dephosphorylation", "Phosphatidylinositol metabolic process", "Phosphatidylinositol phosphate biosynthetic process", "Phosphatidylserine acyl chain remodeling", "Phosphatidylserine metabolic process", "Phospholipase c activating dopamine receptor signaling pathway", "Phospholipase c activating g protein coupled receptor signaling pathway", "Phospholipid biosynthetic process", "Phospholipid catabolic process", "Phospholipid dephosphorylation", "Phospholipid metabolic process", "Phospholipid transport", "Phosphorylation", "Phosphorylation of rna polymerase ii c terminal domain", "Photoperiodism", "Photoreceptor cell development", "Photoreceptor cell differentiation", "Photoreceptor cell maintenance", "Photoreceptor cell outer segment organization", "Phototransduction", "Phototransduction visible light", "Physiological cardiac muscle hypertrophy", "Pigment accumulation", "Pigment biosynthetic process", "Pigment cell differentiation", "Pigment granule localization", "Pigment granule maturation", "Pigment granule organization", "Pigment metabolic process", "Pigmentation", "Pinocytosis", "Pirna metabolic process", "Pituitary gland development", "Placenta blood vessel development", "Placenta development", "Planar cell polarity pathway involved in neural tube closure", "Plasma lipoprotein particle clearance", "Plasma membrane fusion", "Plasma membrane organization", "Plasma membrane phospholipid scrambling", "Plasma membrane raft assembly", "Plasma membrane raft organization", "Plasma membrane repair", "Plasma membrane to endosome transport", "Plasma membrane tubulation", "Plasminogen activation", "Platelet activating factor metabolic process", "Platelet activation", "Platelet aggregation", "Platelet derived growth factor receptor beta signaling pathway", "Platelet derived growth factor receptor signaling pathway", "Platelet morphogenesis", "Plus end directed organelle transport along microtubule", "Pml body organization", "Podosome assembly", "Pointed end actin filament capping", "Polarized epithelial cell differentiation", "Poly a plus mrna export from nucleus", "Poly n acetyllactosamine metabolic process", "Polyadenylation dependent rna catabolic process", "Polyadenylation dependent snorna 3 end processing", "Polyamine biosynthetic process", "Polyamine metabolic process", "Polyketide metabolic process", "Polyol biosynthetic process", "Polyol catabolic process", "Polyol metabolic process", "Polyprenol metabolic process", "Polysaccharide biosynthetic process", "Polysaccharide catabolic process", "Polysaccharide metabolic process", "Pons development", "Pore complex assembly", "Porphyrin containing compound metabolic process", "Positive chemotaxis", "Positive regulation by host of viral genome replication", "Positive regulation by host of viral process", "Positive regulation by host of viral transcription", "Positive regulation by symbiont of entry into host", "Positive regulation of 3 utr mediated mrna stabilization", "Positive regulation of actin cytoskeleton reorganization", "Positive regulation of actin filament bundle assembly", "Positive regulation of actin filament depolymerization", "Positive regulation of actin filament polymerization", "Positive regulation of actin nucleation", "Positive regulation of action potential", "Positive regulation of activated t cell proliferation", "Positive regulation of activin receptor signaling pathway", "Positive regulation of acute inflammatory response", "Positive regulation of acute inflammatory response to antigenic stimulus", "Positive regulation of adaptive immune response", "Positive regulation of adenylate cyclase activity", "Positive regulation of adipose tissue development", "Positive regulation of alcohol biosynthetic process", "Positive regulation of alpha beta t cell activation", "Positive regulation of alpha beta t cell differentiation", "Positive regulation of alpha beta t cell proliferation", "Positive regulation of amine transport", "Positive regulation of amino acid transport", "Positive regulation of amyloid beta clearance", "Positive regulation of amyloid beta formation", "Positive regulation of amyloid precursor protein biosynthetic process", "Positive regulation of amyloid precursor protein catabolic process", "Positive regulation of animal organ morphogenesis", "Positive regulation of anion transmembrane transport", "Positive regulation of anion transport", "Positive regulation of anoikis", "Positive regulation of antigen receptor mediated signaling pathway", "Positive regulation of apoptotic signaling pathway", "Positive regulation of arp2 3 complex mediated actin nucleation", "Positive regulation of aspartic type peptidase activity", "Positive regulation of astrocyte differentiation", "Positive regulation of atp biosynthetic process", "Positive regulation of atp dependent activity", "Positive regulation of atp metabolic process", "Positive regulation of atpase coupled calcium transmembrane transporter activity", "Positive regulation of attachment of spindle microtubules to kinetochore", "Positive regulation of autophagy", "Positive regulation of autophagy of mitochondrion", "Positive regulation of axon extension", "Positive regulation of axonogenesis", "Positive regulation of b cell activation", "Positive regulation of b cell differentiation", "Positive regulation of b cell mediated immunity", "Positive regulation of b cell proliferation", "Positive regulation of b cell receptor signaling pathway", "Positive regulation of basement membrane assembly involved in embryonic body morphogenesis", "Positive regulation of behavior", "Positive regulation of binding", "Positive regulation of biomineralization", "Positive regulation of blood brain barrier permeability", "Positive regulation of blood circulation", "Positive regulation of blood pressure", "Positive regulation of blood pressure by epinephrine norepinephrine", "Positive regulation of blood vessel endothelial cell migration", "Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "Positive regulation of bmp signaling pathway", "Positive regulation of bone mineralization", "Positive regulation of bone resorption", "Positive regulation of brown fat cell differentiation", "Positive regulation of calcineurin mediated signaling", "Positive regulation of calcium ion dependent exocytosis", "Positive regulation of calcium ion import", "Positive regulation of calcium ion transmembrane transport", "Positive regulation of calcium ion transmembrane transporter activity", "Positive regulation of calcium ion transport", "Positive regulation of calcium ion transport into cytosol", "Positive regulation of calcium mediated signaling", "Positive regulation of camp dependent protein kinase activity", "Positive regulation of camp mediated signaling", "Positive regulation of canonical wnt signaling pathway", "Positive regulation of carbohydrate metabolic process", "Positive regulation of cardiac muscle adaptation", "Positive regulation of cardiac muscle cell proliferation", "Positive regulation of cardioblast differentiation", "Positive regulation of cardiocyte differentiation", "Positive regulation of cartilage development", "Positive regulation of catabolic process", "Positive regulation of catalytic activity", "Positive regulation of catecholamine metabolic process", "Positive regulation of cation channel activity", "Positive regulation of cd4 positive alpha beta t cell activation", "Positive regulation of cd4 positive alpha beta t cell differentiation", "Positive regulation of cd8 positive alpha beta t cell activation", "Positive regulation of cd8 positive alpha beta t cell differentiation", "Positive regulation of cell activation", "Positive regulation of cell adhesion", "Positive regulation of cell adhesion mediated by integrin", "Positive regulation of cell adhesion molecule production", "Positive regulation of cell aging", "Positive regulation of cell cell adhesion", "Positive regulation of cell cell adhesion mediated by cadherin", "Positive regulation of cell cell adhesion mediated by integrin", "Positive regulation of cell cycle", "Positive regulation of cell cycle checkpoint", "Positive regulation of cell cycle g1 s phase transition", "Positive regulation of cell cycle g2 m phase transition", "Positive regulation of cell cycle phase transition", "Positive regulation of cell cycle process", "Positive regulation of cell death", "Positive regulation of cell development", "Positive regulation of cell differentiation", "Positive regulation of cell division", "Positive regulation of cell growth", "Positive regulation of cell junction assembly", "Positive regulation of cell killing", "Positive regulation of cell matrix adhesion", "Positive regulation of cell maturation", "Positive regulation of cell migration by vascular endothelial growth factor signaling pathway", "Positive regulation of cell migration involved in sprouting angiogenesis", "Positive regulation of cell morphogenesis involved in differentiation", "Positive regulation of cell population proliferation", "Positive regulation of cell projection organization", "Positive regulation of cell proliferation in bone marrow", "Positive regulation of cell proliferation involved in heart morphogenesis", "Positive regulation of cell size", "Positive regulation of cell substrate adhesion", "Positive regulation of cell substrate junction organization", "Positive regulation of cellular amide metabolic process", "Positive regulation of cellular amine metabolic process", "Positive regulation of cellular biosynthetic process", "Positive regulation of cellular carbohydrate metabolic process", "Positive regulation of cellular component biogenesis", "Positive regulation of cellular component organization", "Positive regulation of cellular extravasation", "Positive regulation of cellular ph reduction", "Positive regulation of cellular protein catabolic process", "Positive regulation of cellular respiration", "Positive regulation of cellular response to insulin stimulus", "Positive regulation of cellular response to transforming growth factor beta stimulus", "Positive regulation of centriole elongation", "Positive regulation of centriole replication", "Positive regulation of chemokine c c motif ligand 5 production", "Positive regulation of chemokine c x c motif ligand 2 production", "Positive regulation of chemokine production", "Positive regulation of chemotaxis", "Positive regulation of cholesterol biosynthetic process", "Positive regulation of cholesterol efflux", "Positive regulation of cholesterol metabolic process", "Positive regulation of cholesterol storage", "Positive regulation of chondrocyte differentiation", "Positive regulation of chromatin binding", "Positive regulation of chromatin organization", "Positive regulation of chromosome condensation", "Positive regulation of chromosome organization", "Positive regulation of chromosome segregation", "Positive regulation of chromosome separation", "Positive regulation of cilium assembly", "Positive regulation of circadian rhythm", "Positive regulation of clathrin dependent endocytosis", "Positive regulation of coagulation", "Positive regulation of cold induced thermogenesis", "Positive regulation of collagen metabolic process", "Positive regulation of collateral sprouting", "Positive regulation of complement activation", "Positive regulation of connective tissue replacement", "Positive regulation of cyclase activity", "Positive regulation of cyclic nucleotide phosphodiesterase activity", "Positive regulation of cyclin dependent protein kinase activity", "Positive regulation of cysteine type endopeptidase activity", "Positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Positive regulation of cytokine production", "Positive regulation of cytokine production involved in immune response", "Positive regulation of cytokine production involved in inflammatory response", "Positive regulation of cytokinesis", "Positive regulation of cytoplasmic translation", "Positive regulation of cytoplasmic transport", "Positive regulation of cytoskeleton organization", "Positive regulation of deacetylase activity", "Positive regulation of defense response", "Positive regulation of defense response to virus by host", "Positive regulation of dendrite development", "Positive regulation of dendrite morphogenesis", "Positive regulation of dendritic cell cytokine production", "Positive regulation of dendritic cell differentiation", "Positive regulation of dendritic spine development", "Positive regulation of dendritic spine morphogenesis", "Positive regulation of deoxyribonuclease activity", "Positive regulation of dephosphorylation", "Positive regulation of developmental growth", "Positive regulation of developmental process", "Positive regulation of dna binding", "Positive regulation of dna binding transcription factor activity", "Positive regulation of dna biosynthetic process", "Positive regulation of dna damage response signal transduction by p53 class mediator", "Positive regulation of dna demethylation", "Positive regulation of dna dependent dna replication", "Positive regulation of dna ligation", "Positive regulation of dna metabolic process", "Positive regulation of dna methylation dependent heterochromatin assembly", "Positive regulation of dna recombination", "Positive regulation of dna repair", "Positive regulation of dna replication", "Positive regulation of dna templated transcription elongation", "Positive regulation of dna templated transcription initiation", "Positive regulation of dopamine receptor signaling pathway", "Positive regulation of double strand break repair", "Positive regulation of double strand break repair via homologous recombination", "Positive regulation of double strand break repair via nonhomologous end joining", "Positive regulation of early endosome to late endosome transport", "Positive regulation of embryonic development", "Positive regulation of endocytic recycling", "Positive regulation of endocytosis", "Positive regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Positive regulation of endoplasmic reticulum unfolded protein response", "Positive regulation of endothelial cell apoptotic process", "Positive regulation of endothelial cell chemotaxis", "Positive regulation of endothelial cell chemotaxis by vegf activated vascular endothelial growth factor receptor signaling pathway", "Positive regulation of endothelial cell development", "Positive regulation of endothelial cell differentiation", "Positive regulation of endothelial cell matrix adhesion via fibronectin", "Positive regulation of endothelial cell migration", "Positive regulation of endothelial cell proliferation", "Positive regulation of epidermal cell differentiation", "Positive regulation of epidermis development", "Positive regulation of epithelial cell apoptotic process", "Positive regulation of epithelial cell differentiation", "Positive regulation of epithelial cell migration", "Positive regulation of epithelial cell proliferation", "Positive regulation of epithelial cell proliferation involved in lung morphogenesis", "Positive regulation of epithelial to mesenchymal transition", "Positive regulation of er associated ubiquitin dependent protein catabolic process", "Positive regulation of erad pathway", "Positive regulation of erbb signaling pathway", "Positive regulation of erk1 and erk2 cascade", "Positive regulation of erythrocyte differentiation", "Positive regulation of establishment of protein localization", "Positive regulation of establishment of protein localization to mitochondrion", "Positive regulation of establishment of protein localization to telomere", "Positive regulation of excitatory postsynaptic potential", "Positive regulation of execution phase of apoptosis", "Positive regulation of exocytosis", "Positive regulation of exosomal secretion", "Positive regulation of extracellular matrix assembly", "Positive regulation of extracellular matrix disassembly", "Positive regulation of extracellular matrix organization", "Positive regulation of extrinsic apoptotic signaling pathway", "Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Positive regulation of fat cell differentiation", "Positive regulation of fatty acid beta oxidation", "Positive regulation of fatty acid biosynthetic process", "Positive regulation of fatty acid metabolic process", "Positive regulation of fatty acid oxidation", "Positive regulation of fatty acid transport", "Positive regulation of fc receptor mediated stimulatory signaling pathway", "Positive regulation of feeding behavior", "Positive regulation of fibroblast growth factor receptor signaling pathway", "Positive regulation of fibroblast migration", "Positive regulation of fibroblast proliferation", "Positive regulation of filopodium assembly", "Positive regulation of focal adhesion assembly", "Positive regulation of g protein coupled receptor signaling pathway", "Positive regulation of g0 to g1 transition", "Positive regulation of g1 s transition of mitotic cell cycle", "Positive regulation of gastrulation", "Positive regulation of gene expression", "Positive regulation of glial cell differentiation", "Positive regulation of glial cell migration", "Positive regulation of glial cell proliferation", "Positive regulation of gliogenesis", "Positive regulation of glucokinase activity", "Positive regulation of gluconeogenesis", "Positive regulation of glucose import", "Positive regulation of glucose metabolic process", "Positive regulation of glucose transmembrane transport", "Positive regulation of glutamate secretion", "Positive regulation of glycogen metabolic process", "Positive regulation of glycolytic process", "Positive regulation of glycoprotein metabolic process", "Positive regulation of golgi to plasma membrane protein transport", "Positive regulation of gonad development", "Positive regulation of granulocyte chemotaxis", "Positive regulation of growth", "Positive regulation of gtpase activity", "Positive regulation of hair follicle development", "Positive regulation of heart growth", "Positive regulation of heart rate", "Positive regulation of helicase activity", "Positive regulation of hematopoietic progenitor cell differentiation", "Positive regulation of hematopoietic stem cell proliferation", "Positive regulation of hemopoiesis", "Positive regulation of heterotypic cell cell adhesion", "Positive regulation of hexokinase activity", "Positive regulation of hippo signaling", "Positive regulation of histone acetylation", "Positive regulation of histone deacetylation", "Positive regulation of histone h3 k27 methylation", "Positive regulation of histone h3 k4 methylation", "Positive regulation of histone h3 k9 acetylation", "Positive regulation of histone h3 k9 methylation", "Positive regulation of histone h4 acetylation", "Positive regulation of histone methylation", "Positive regulation of histone modification", "Positive regulation of histone phosphorylation", "Positive regulation of histone ubiquitination", "Positive regulation of homotypic cell cell adhesion", "Positive regulation of hormone biosynthetic process", "Positive regulation of hormone metabolic process", "Positive regulation of hormone secretion", "Positive regulation of humoral immune response", "Positive regulation of hydrogen peroxide mediated programmed cell death", "Positive regulation of hydrogen peroxide metabolic process", "Positive regulation of hydrolase activity", "Positive regulation of i kappab kinase nf kappab signaling", "Positive regulation of i kappab phosphorylation", "Positive regulation of immune effector process", "Positive regulation of immune response", "Positive regulation of immune system process", "Positive regulation of immunoglobulin production", "Positive regulation of inclusion body assembly", "Positive regulation of inflammatory response", "Positive regulation of inflammatory response to antigenic stimulus", "Positive regulation of innate immune response", "Positive regulation of insulin like growth factor receptor signaling pathway", "Positive regulation of insulin secretion", "Positive regulation of insulin secretion involved in cellular response to glucose stimulus", "Positive regulation of integrin activation", "Positive regulation of integrin mediated signaling pathway", "Positive regulation of interferon alpha production", "Positive regulation of interferon beta production", "Positive regulation of interferon gamma production", "Positive regulation of interleukin 1 beta production", "Positive regulation of interleukin 1 production", "Positive regulation of interleukin 10 production", "Positive regulation of interleukin 12 production", "Positive regulation of interleukin 17 production", "Positive regulation of interleukin 18 production", "Positive regulation of interleukin 2 production", "Positive regulation of interleukin 4 production", "Positive regulation of interleukin 6 production", "Positive regulation of interleukin 8 production", "Positive regulation of intracellular lipid transport", "Positive regulation of intracellular protein transport", "Positive regulation of intracellular signal transduction", "Positive regulation of intracellular steroid hormone receptor signaling pathway", "Positive regulation of intracellular transport", "Positive regulation of intrinsic apoptotic signaling pathway", "Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Positive regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Positive regulation of ion transmembrane transport", "Positive regulation of ion transport", "Positive regulation of ire1 mediated unfolded protein response", "Positive regulation of isotype switching", "Positive regulation of isotype switching to iga isotypes", "Positive regulation of isotype switching to igg isotypes", "Positive regulation of jnk cascade", "Positive regulation of jun kinase activity", "Positive regulation of keratinocyte differentiation", "Positive regulation of kinase activity", "Positive regulation of lamellipodium assembly", "Positive regulation of lamellipodium morphogenesis", "Positive regulation of lamellipodium organization", "Positive regulation of leukocyte apoptotic process", "Positive regulation of leukocyte cell cell adhesion", "Positive regulation of leukocyte chemotaxis", "Positive regulation of leukocyte degranulation", "Positive regulation of leukocyte mediated immunity", "Positive regulation of leukocyte migration", "Positive regulation of leukocyte proliferation", "Positive regulation of ligase activity", "Positive regulation of lipase activity", "Positive regulation of lipid biosynthetic process", "Positive regulation of lipid catabolic process", "Positive regulation of lipid kinase activity", "Positive regulation of lipid localization", "Positive regulation of lipid metabolic process", "Positive regulation of lipid storage", "Positive regulation of lipid transport", "Positive regulation of lipopolysaccharide mediated signaling pathway", "Positive regulation of lipoprotein particle clearance", "Positive regulation of locomotion", "Positive regulation of long term synaptic potentiation", "Positive regulation of low density lipoprotein receptor activity", "Positive regulation of lyase activity", "Positive regulation of lymphocyte anergy", "Positive regulation of lymphocyte apoptotic process", "Positive regulation of lymphocyte chemotaxis", "Positive regulation of lymphocyte differentiation", "Positive regulation of lymphocyte mediated immunity", "Positive regulation of lymphocyte migration", "Positive regulation of macroautophagy", "Positive regulation of macrophage activation", "Positive regulation of macrophage chemotaxis", "Positive regulation of macrophage cytokine production", "Positive regulation of macrophage differentiation", "Positive regulation of macrophage migration", "Positive regulation of maintenance of sister chromatid cohesion", "Positive regulation of mammary gland epithelial cell proliferation", "Positive regulation of map kinase activity", "Positive regulation of mapk cascade", "Positive regulation of mast cell activation", "Positive regulation of mast cell activation involved in immune response", "Positive regulation of mast cell chemotaxis", "Positive regulation of megakaryocyte differentiation", "Positive regulation of meiotic cell cycle", "Positive regulation of meiotic nuclear division", "Positive regulation of membrane depolarization", "Positive regulation of membrane permeability", "Positive regulation of membrane potential", "Positive regulation of membrane protein ectodomain proteolysis", "Positive regulation of mesenchymal cell proliferation", "Positive regulation of mesenchymal stem cell proliferation", "Positive regulation of metalloendopeptidase activity", "Positive regulation of metallopeptidase activity", "Positive regulation of metaphase anaphase transition of cell cycle", "Positive regulation of mhc class i biosynthetic process", "Positive regulation of mhc class ii biosynthetic process", "Positive regulation of microglial cell activation", "Positive regulation of microtubule binding", "Positive regulation of microtubule nucleation", "Positive regulation of microtubule polymerization or depolymerization", "Positive regulation of mirna catabolic process", "Positive regulation of mirna mediated gene silencing by inhibition of translation", "Positive regulation of mirna metabolic process", "Positive regulation of mirna transcription", "Positive regulation of mitochondrial calcium ion concentration", "Positive regulation of mitochondrial depolarization", "Positive regulation of mitochondrial fission", "Positive regulation of mitochondrial membrane potential", "Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Positive regulation of mitochondrial translation", "Positive regulation of mitochondrion organization", "Positive regulation of mitophagy", "Positive regulation of mitophagy in response to mitochondrial depolarization", "Positive regulation of mitotic cell cycle", "Positive regulation of mitotic cell cycle phase transition", "Positive regulation of mitotic cell cycle spindle assembly checkpoint", "Positive regulation of mitotic nuclear division", "Positive regulation of molecular function", "Positive regulation of monocyte chemotaxis", "Positive regulation of monocyte differentiation", "Positive regulation of mononuclear cell migration", "Positive regulation of monooxygenase activity", "Positive regulation of morphogenesis of an epithelium", "Positive regulation of mrna 3 end processing", "Positive regulation of mrna metabolic process", "Positive regulation of mrna processing", "Positive regulation of mrna splicing via spliceosome", "Positive regulation of multicellular organism growth", "Positive regulation of multicellular organismal process", "Positive regulation of muscle adaptation", "Positive regulation of muscle cell apoptotic process", "Positive regulation of muscle cell differentiation", "Positive regulation of muscle contraction", "Positive regulation of muscle hypertrophy", "Positive regulation of muscle tissue development", "Positive regulation of myelination", "Positive regulation of myeloid cell apoptotic process", "Positive regulation of myeloid cell differentiation", "Positive regulation of myeloid leukocyte cytokine production involved in immune response", "Positive regulation of myeloid leukocyte differentiation", "Positive regulation of myeloid leukocyte mediated immunity", "Positive regulation of myoblast differentiation", "Positive regulation of myoblast fusion", "Positive regulation of myotube differentiation", "Positive regulation of nad p h oxidase activity", "Positive regulation of natural killer cell activation", "Positive regulation of natural killer cell mediated cytotoxicity", "Positive regulation of natural killer cell mediated immunity", "Positive regulation of necrotic cell death", "Positive regulation of nervous system development", "Positive regulation of nervous system process", "Positive regulation of neural precursor cell proliferation", "Positive regulation of neuroblast proliferation", "Positive regulation of neurogenesis", "Positive regulation of neuroinflammatory response", "Positive regulation of neuron apoptotic process", "Positive regulation of neuron death", "Positive regulation of neuron differentiation", "Positive regulation of neuron migration", "Positive regulation of neuron projection arborization", "Positive regulation of neuron projection development", "Positive regulation of neuron projection regeneration", "Positive regulation of neurotransmitter secretion", "Positive regulation of neurotransmitter transport", "Positive regulation of neurotransmitter uptake", "Positive regulation of neurotrophin trk receptor signaling pathway", "Positive regulation of neutrophil migration", "Positive regulation of nf kappab transcription factor activity", "Positive regulation of nik nf kappab signaling", "Positive regulation of nitric oxide metabolic process", "Positive regulation of nitric oxide synthase activity", "Positive regulation of nitric oxide synthase biosynthetic process", "Positive regulation of nk t cell activation", "Positive regulation of nlrp3 inflammasome complex assembly", "Positive regulation of non motile cilium assembly", "Positive regulation of notch signaling pathway", "Positive regulation of nuclear cell cycle dna replication", "Positive regulation of nuclear division", "Positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Positive regulation of nuclease activity", "Positive regulation of nucleobase containing compound metabolic process", "Positive regulation of nucleobase containing compound transport", "Positive regulation of nucleocytoplasmic transport", "Positive regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Positive regulation of nucleotide binding oligomerization domain containing signaling pathway", "Positive regulation of nucleotide biosynthetic process", "Positive regulation of nucleotide metabolic process", "Positive regulation of oligodendrocyte differentiation", "Positive regulation of organ growth", "Positive regulation of organelle assembly", "Positive regulation of organelle organization", "Positive regulation of organic acid transport", "Positive regulation of ossification", "Positive regulation of osteoblast differentiation", "Positive regulation of osteoblast proliferation", "Positive regulation of oxidative stress induced cell death", "Positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Positive regulation of oxidative stress induced neuron death", "Positive regulation of oxidoreductase activity", "Positive regulation of p38mapk cascade", "Positive regulation of pathway restricted smad protein phosphorylation", "Positive regulation of pattern recognition receptor signaling pathway", "Positive regulation of peptidase activity", "Positive regulation of peptide secretion", "Positive regulation of peptidyl lysine acetylation", "Positive regulation of peptidyl serine phosphorylation", "Positive regulation of peptidyl threonine phosphorylation", "Positive regulation of peptidyl tyrosine phosphorylation", "Positive regulation of phagocytosis", "Positive regulation of phosphatase activity", "Positive regulation of phosphatidylinositol 3 kinase signaling", "Positive regulation of phospholipase a2 activity", "Positive regulation of phospholipase activity", "Positive regulation of phospholipid biosynthetic process", "Positive regulation of phospholipid metabolic process", "Positive regulation of phosphoprotein phosphatase activity", "Positive regulation of phosphorus metabolic process", "Positive regulation of pinocytosis", "Positive regulation of plasma membrane bounded cell projection assembly", "Positive regulation of plasminogen activation", "Positive regulation of platelet aggregation", "Positive regulation of podosome assembly", "Positive regulation of posttranscriptional gene silencing", "Positive regulation of potassium ion import across plasma membrane", "Positive regulation of potassium ion transmembrane transporter activity", "Positive regulation of potassium ion transport", "Positive regulation of production of mirnas involved in gene silencing by mirna", "Positive regulation of production of molecular mediator of immune response", "Positive regulation of programmed necrotic cell death", "Positive regulation of prostaglandin biosynthetic process", "Positive regulation of proteasomal ubiquitin dependent protein catabolic process", "Positive regulation of protein acetylation", "Positive regulation of protein autophosphorylation", "Positive regulation of protein binding", "Positive regulation of protein catabolic process", "Positive regulation of protein catabolic process in the vacuole", "Positive regulation of protein containing complex assembly", "Positive regulation of protein containing complex disassembly", "Positive regulation of protein deacetylation", "Positive regulation of protein dephosphorylation", "Positive regulation of protein depolymerization", "Positive regulation of protein deubiquitination", "Positive regulation of protein exit from endoplasmic reticulum", "Positive regulation of protein export from nucleus", "Positive regulation of protein glycosylation", "Positive regulation of protein import", "Positive regulation of protein k63 linked ubiquitination", "Positive regulation of protein kinase a signaling", "Positive regulation of protein kinase activity", "Positive regulation of protein kinase b signaling", "Positive regulation of protein localization", "Positive regulation of protein localization to cell cortex", "Positive regulation of protein localization to cell periphery", "Positive regulation of protein localization to cell surface", "Positive regulation of protein localization to centrosome", "Positive regulation of protein localization to early endosome", "Positive regulation of protein localization to membrane", "Positive regulation of protein localization to nucleus", "Positive regulation of protein maturation", "Positive regulation of protein metabolic process", "Positive regulation of protein modification by small protein conjugation or removal", "Positive regulation of protein modification process", "Positive regulation of protein monoubiquitination", "Positive regulation of protein neddylation", "Positive regulation of protein phosphorylation", "Positive regulation of protein polymerization", "Positive regulation of protein polyubiquitination", "Positive regulation of protein secretion", "Positive regulation of protein serine threonine kinase activity", "Positive regulation of protein sumoylation", "Positive regulation of protein targeting to membrane", "Positive regulation of protein tyrosine kinase activity", "Positive regulation of proteolysis", "Positive regulation of proteolysis involved in cellular protein catabolic process", "Positive regulation of pseudopodium assembly", "Positive regulation of reactive oxygen species biosynthetic process", "Positive regulation of reactive oxygen species metabolic process", "Positive regulation of receptor binding", "Positive regulation of receptor catabolic process", "Positive regulation of receptor clustering", "Positive regulation of receptor internalization", "Positive regulation of receptor mediated endocytosis", "Positive regulation of receptor recycling", "Positive regulation of receptor signaling pathway via stat", "Positive regulation of regulated secretory pathway", "Positive regulation of release of cytochrome c from mitochondria", "Positive regulation of release of sequestered calcium ion into cytosol", "Positive regulation of renal sodium excretion", "Positive regulation of reproductive process", "Positive regulation of respiratory burst", "Positive regulation of response to biotic stimulus", "Positive regulation of response to cytokine stimulus", "Positive regulation of response to dna damage stimulus", "Positive regulation of response to endoplasmic reticulum stress", "Positive regulation of response to external stimulus", "Positive regulation of response to oxidative stress", "Positive regulation of response to reactive oxygen species", "Positive regulation of response to tumor cell", "Positive regulation of response to wounding", "Positive regulation of retinoic acid receptor signaling pathway", "Positive regulation of rho protein signal transduction", "Positive regulation of rig i signaling pathway", "Positive regulation of rna binding", "Positive regulation of rna export from nucleus", "Positive regulation of rna metabolic process", "Positive regulation of rna polymerase ii transcription preinitiation complex assembly", "Positive regulation of rna splicing", "Positive regulation of rrna processing", "Positive regulation of ruffle assembly", "Positive regulation of ryanodine sensitive calcium release channel activity", "Positive regulation of secondary metabolite biosynthetic process", "Positive regulation of secretion", "Positive regulation of sequestering of calcium ion", "Positive regulation of sequestering of triglyceride", "Positive regulation of signal transduction by p53 class mediator", "Positive regulation of signaling", "Positive regulation of signaling receptor activity", "Positive regulation of sister chromatid cohesion", "Positive regulation of skeletal muscle tissue development", "Positive regulation of smad protein signal transduction", "Positive regulation of small gtpase mediated signal transduction", "Positive regulation of small molecule metabolic process", "Positive regulation of smooth muscle cell apoptotic process", "Positive regulation of smooth muscle cell differentiation", "Positive regulation of smooth muscle cell migration", "Positive regulation of smooth muscle cell proliferation", "Positive regulation of smooth muscle contraction", "Positive regulation of smoothened signaling pathway", "Positive regulation of sodium ion transmembrane transport", "Positive regulation of sodium ion transmembrane transporter activity", "Positive regulation of sodium ion transport", "Positive regulation of spindle assembly", "Positive regulation of sprouting angiogenesis", "Positive regulation of stem cell differentiation", "Positive regulation of stem cell proliferation", "Positive regulation of steroid biosynthetic process", "Positive regulation of steroid hormone biosynthetic process", "Positive regulation of steroid metabolic process", "Positive regulation of sterol transport", "Positive regulation of stress activated protein kinase signaling cascade", "Positive regulation of stress fiber assembly", "Positive regulation of striated muscle cell apoptotic process", "Positive regulation of striated muscle cell differentiation", "Positive regulation of striated muscle contraction", "Positive regulation of substrate adhesion dependent cell spreading", "Positive regulation of supramolecular fiber organization", "Positive regulation of synapse assembly", "Positive regulation of synapse maturation", "Positive regulation of synaptic plasticity", "Positive regulation of synaptic transmission", "Positive regulation of synaptic transmission gabaergic", "Positive regulation of synaptic transmission glutamatergic", "Positive regulation of synaptic vesicle endocytosis", "Positive regulation of synaptic vesicle exocytosis", "Positive regulation of synaptic vesicle recycling", "Positive regulation of syncytium formation by plasma membrane fusion", "Positive regulation of systemic arterial blood pressure", "Positive regulation of t cell apoptotic process", "Positive regulation of t cell cytokine production", "Positive regulation of t cell mediated cytotoxicity", "Positive regulation of t cell mediated immune response to tumor cell", "Positive regulation of t cell mediated immunity", "Positive regulation of t cell migration", "Positive regulation of t cell proliferation", "Positive regulation of t cell receptor signaling pathway", "Positive regulation of t cell tolerance induction", "Positive regulation of t helper 1 cell differentiation", "Positive regulation of t helper cell differentiation", "Positive regulation of tau protein kinase activity", "Positive regulation of telomerase activity", "Positive regulation of telomerase rna localization to cajal body", "Positive regulation of telomere capping", "Positive regulation of telomere maintenance", "Positive regulation of telomere maintenance via telomere lengthening", "Positive regulation of tissue remodeling", "Positive regulation of tolerance induction", "Positive regulation of toll like receptor 3 signaling pathway", "Positive regulation of toll like receptor 9 signaling pathway", "Positive regulation of toll like receptor signaling pathway", "Positive regulation of tor signaling", "Positive regulation of torc1 signaling", "Positive regulation of transcription by rna polymerase i", "Positive regulation of transcription by rna polymerase ii", "Positive regulation of transcription by rna polymerase iii", "Positive regulation of transcription elongation from rna polymerase ii promoter", "Positive regulation of transcription from rna polymerase ii promoter in response to endoplasmic reticulum stress", "Positive regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Positive regulation of transcription from rna polymerase ii promoter in response to stress", "Positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus", "Positive regulation of transcription of notch receptor target", "Positive regulation of transcription of nucleolar large rrna by rna polymerase i", "Positive regulation of transcription regulatory region dna binding", "Positive regulation of transferase activity", "Positive regulation of translation", "Positive regulation of translation in response to endoplasmic reticulum stress", "Positive regulation of translation in response to stress", "Positive regulation of translational initiation", "Positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Positive regulation of transmembrane transport", "Positive regulation of transmission of nerve impulse", "Positive regulation of transport", "Positive regulation of transporter activity", "Positive regulation of triglyceride biosynthetic process", "Positive regulation of triglyceride metabolic process", "Positive regulation of trophoblast cell migration", "Positive regulation of tumor necrosis factor mediated signaling pathway", "Positive regulation of tumor necrosis factor superfamily cytokine production", "Positive regulation of type i interferon mediated signaling pathway", "Positive regulation of type i interferon production", "Positive regulation of tyrosine phosphorylation of stat protein", "Positive regulation of ubiquitin dependent protein catabolic process", "Positive regulation of ubiquitin protein ligase activity", "Positive regulation of ubiquitin protein transferase activity", "Positive regulation of unsaturated fatty acid biosynthetic process", "Positive regulation of urine volume", "Positive regulation of vacuole organization", "Positive regulation of vascular associated smooth muscle cell apoptotic process", "Positive regulation of vascular associated smooth muscle cell differentiation", "Positive regulation of vascular associated smooth muscle cell migration", "Positive regulation of vascular associated smooth muscle cell proliferation", "Positive regulation of vascular endothelial cell proliferation", "Positive regulation of vascular endothelial growth factor receptor signaling pathway", "Positive regulation of vascular endothelial growth factor signaling pathway", "Positive regulation of vascular permeability", "Positive regulation of vasculature development", "Positive regulation of vasculogenesis", "Positive regulation of vesicle fusion", "Positive regulation of viral genome replication", "Positive regulation of viral life cycle", "Positive regulation of viral process", "Positive regulation of vitamin d receptor signaling pathway", "Positive regulation of voltage gated calcium channel activity", "Positive regulation of wnt signaling pathway", "Positive regulation of wound healing", "Positive regulation of wound healing spreading of epidermal cells", "Positive t cell selection", "Post anal tail morphogenesis", "Post chaperonin tubulin folding pathway", "Post embryonic development", "Post golgi vesicle mediated transport", "Post translational protein modification", "Postreplication repair", "Postsynapse assembly", "Postsynapse organization", "Postsynapse to nucleus signaling pathway", "Postsynaptic actin cytoskeleton organization", "Postsynaptic cytoskeleton organization", "Postsynaptic density protein 95 clustering", "Postsynaptic membrane assembly", "Postsynaptic membrane organization", "Postsynaptic modulation of chemical synaptic transmission", "Postsynaptic neurotransmitter receptor internalization", "Postsynaptic signal transduction", "Postsynaptic specialization organization", "Posttranscriptional regulation of gene expression", "Posttranslational protein targeting to endoplasmic reticulum membrane", "Posttranslational protein targeting to membrane translocation", "Potassium ion export across plasma membrane", "Potassium ion homeostasis", "Potassium ion import across plasma membrane", "Potassium ion transport", "Pre mirna processing", "Prenylation", "Presynapse organization", "Presynaptic active zone organization", "Presynaptic endocytosis", "Presynaptic modulation of chemical synaptic transmission", "Prevention of polyspermy", "Primary alcohol biosynthetic process", "Primary alcohol catabolic process", "Primary alcohol metabolic process", "Primary amino compound biosynthetic process", "Primary amino compound metabolic process", "Primary mirna processing", "Primitive hemopoiesis", "Pro b cell differentiation", "Process utilizing autophagic mechanism", "Production of molecular mediator involved in inflammatory response", "Production of molecular mediator of immune response", "Production of sirna involved in rna interference", "Progesterone biosynthetic process", "Progesterone metabolic process", "Progesterone receptor signaling pathway", "Programmed cell death", "Programmed cell death in response to reactive oxygen species", "Programmed cell death involved in cell development", "Programmed necrotic cell death", "Prolactin secretion", "Proline metabolic process", "Pronephros development", "Proprioception", "Prostaglandin transport", "Prostanoid biosynthetic process", "Prostanoid metabolic process", "Prostate gland development", "Prostate gland growth", "Prosthetic group metabolic process", "Proteasomal protein catabolic process", "Proteasome assembly", "Proteasome mediated ubiquitin dependent protein catabolic process", "Protection from natural killer cell mediated cytotoxicity", "Protection from non homologous end joining at telomere", "Protein acetylation", "Protein activation cascade", "Protein acylation", "Protein adp ribosylation", "Protein auto adp ribosylation", "Protein autophosphorylation", "Protein autoprocessing", "Protein autoubiquitination", "Protein catabolic process", "Protein catabolic process in the vacuole", "Protein complex oligomerization", "Protein containing complex disassembly", "Protein containing complex localization", "Protein containing complex organization", "Protein containing complex remodeling", "Protein deglycosylation", "Protein demannosylation", "Protein demethylation", "Protein deneddylation", "Protein depalmitoylation", "Protein dephosphorylation", "Protein depolymerization", "Protein destabilization", "Protein desumoylation", "Protein deubiquitination involved in ubiquitin dependent protein catabolic process", "Protein dna complex assembly", "Protein dna complex disassembly", "Protein dna complex subunit organization", "Protein dna covalent cross linking repair", "Protein exit from endoplasmic reticulum", "Protein export from nucleus", "Protein folding", "Protein folding in endoplasmic reticulum", "Protein geranylgeranylation", "Protein heterooligomerization", "Protein heterotetramerization", "Protein hexamerization", "Protein homooligomerization", "Protein homotetramerization", "Protein hydroxylation", "Protein import", "Protein import into mitochondrial matrix", "Protein import into peroxisome matrix", "Protein import into peroxisome membrane", "Protein insertion into er membrane", "Protein insertion into er membrane by stop transfer membrane anchor sequence", "Protein insertion into membrane", "Protein insertion into mitochondrial inner membrane", "Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway", "Protein k11 linked ubiquitination", "Protein k27 linked ubiquitination", "Protein k29 linked ubiquitination", "Protein k48 linked deubiquitination", "Protein k48 linked ubiquitination", "Protein k6 linked ubiquitination", "Protein k63 linked deubiquitination", "Protein k63 linked ubiquitination", "Protein kinase a signaling", "Protein kinase b signaling", "Protein kinase c signaling", "Protein lipid complex assembly", "Protein lipid complex subunit organization", "Protein localization to adherens junction", "Protein localization to axon", "Protein localization to basolateral plasma membrane", "Protein localization to cell cell junction", "Protein localization to cell cortex", "Protein localization to cell junction", "Protein localization to cell periphery", "Protein localization to cell surface", "Protein localization to chromatin", "Protein localization to chromosome", "Protein localization to chromosome centromeric region", "Protein localization to chromosome telomeric region", "Protein localization to ciliary membrane", "Protein localization to cilium", "Protein localization to condensed chromosome", "Protein localization to cytoplasmic stress granule", "Protein localization to cytoskeleton", "Protein localization to early endosome", "Protein localization to endoplasmic reticulum", "Protein localization to endoplasmic reticulum exit site", "Protein localization to endosome", "Protein localization to extracellular region", "Protein localization to golgi apparatus", "Protein localization to lysosome", "Protein localization to membrane raft", "Protein localization to microtubule", "Protein localization to microtubule end", "Protein localization to microtubule organizing center", "Protein localization to mitochondrion", "Protein localization to non motile cilium", "Protein localization to nuclear body", "Protein localization to nuclear envelope", "Protein localization to nucleolus", "Protein localization to nucleoplasm", "Protein localization to nucleus", "Protein localization to organelle", "Protein localization to perinuclear region of cytoplasm", "Protein localization to phagophore assembly site", "Protein localization to plasma membrane", "Protein localization to postsynapse", "Protein localization to presynapse", "Protein localization to synapse", "Protein localization to vacuole", "Protein mannosylation", "Protein maturation", "Protein maturation by 4fe 4s cluster transfer", "Protein maturation by iron sulfur cluster transfer", "Protein maturation by protein folding", "Protein methylation", "Protein modification by small protein conjugation", "Protein modification by small protein conjugation or removal", "Protein modification by small protein removal", "Protein monoubiquitination", "Protein n linked glycosylation", "Protein neddylation", "Protein nitrosylation", "Protein o linked glycosylation", "Protein o linked glycosylation via serine", "Protein o linked glycosylation via threonine", "Protein o linked mannosylation", "Protein oxidation", "Protein peptidyl prolyl isomerization", "Protein poly adp ribosylation", "Protein polyglutamylation", "Protein polymerization", "Protein polyubiquitination", "Protein polyufmylation", "Protein processing", "Protein processing involved in protein targeting to mitochondrion", "Protein quality control for misfolded or incompletely synthesized proteins", "Protein refolding", "Protein repair", "Protein retention in er lumen", "Protein stabilization", "Protein sumoylation", "Protein targeting", "Protein targeting to lysosome", "Protein targeting to membrane", "Protein targeting to mitochondrion", "Protein targeting to peroxisome", "Protein targeting to vacuole", "Protein tetramerization", "Protein transmembrane import into intracellular organelle", "Protein transmembrane transport", "Protein transport along microtubule", "Protein transport to vacuole involved in ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Protein transport within lipid bilayer", "Protein trimerization", "Protein ufmylation", "Proteoglycan biosynthetic process", "Proteoglycan metabolic process", "Proteolysis", "Proton transmembrane transport", "Proton transporting two sector atpase complex assembly", "Proton transporting v type atpase complex assembly", "Protoporphyrinogen ix biosynthetic process", "Protoporphyrinogen ix metabolic process", "Proximal distal pattern formation", "Proximal tubule development", "Pseudopodium organization", "Pseudouridine synthesis", "Pteridine containing compound biosynthetic process", "Pteridine containing compound metabolic process", "Pulmonary valve development", "Pulmonary valve morphogenesis", "Purine containing compound biosynthetic process", "Purine containing compound catabolic process", "Purine containing compound metabolic process", "Purine containing compound salvage", "Purine containing compound transmembrane transport", "Purine deoxyribonucleoside metabolic process", "Purine deoxyribonucleoside monophosphate catabolic process", "Purine deoxyribonucleoside monophosphate metabolic process", "Purine deoxyribonucleoside triphosphate metabolic process", "Purine deoxyribonucleotide biosynthetic process", "Purine deoxyribonucleotide catabolic process", "Purine deoxyribonucleotide metabolic process", "Purine nucleobase biosynthetic process", "Purine nucleobase metabolic process", "Purine nucleoside biosynthetic process", "Purine nucleoside catabolic process", "Purine nucleoside diphosphate biosynthetic process", "Purine nucleoside diphosphate catabolic process", "Purine nucleoside metabolic process", "Purine nucleoside monophosphate biosynthetic process", "Purine nucleoside monophosphate catabolic process", "Purine nucleoside monophosphate metabolic process", "Purine nucleoside triphosphate catabolic process", "Purine nucleotide catabolic process", "Purine nucleotide salvage", "Purine nucleotide transport", "Purine ribonucleoside catabolic process", "Purine ribonucleoside metabolic process", "Purine ribonucleoside salvage", "Purine ribonucleotide salvage", "Purinergic nucleotide receptor signaling pathway", "Putrescine metabolic process", "Pyramidal neuron development", "Pyramidal neuron differentiation", "Pyridine containing compound biosynthetic process", "Pyridine containing compound catabolic process", "Pyridine containing compound metabolic process", "Pyridine nucleotide biosynthetic process", "Pyridine nucleotide metabolic process", "Pyrimidine containing compound biosynthetic process", "Pyrimidine containing compound catabolic process", "Pyrimidine containing compound metabolic process", "Pyrimidine containing compound transmembrane transport", "Pyrimidine deoxyribonucleoside metabolic process", "Pyrimidine deoxyribonucleoside monophosphate biosynthetic process", "Pyrimidine deoxyribonucleoside monophosphate metabolic process", "Pyrimidine deoxyribonucleoside triphosphate metabolic process", "Pyrimidine deoxyribonucleotide biosynthetic process", "Pyrimidine deoxyribonucleotide metabolic process", "Pyrimidine dimer repair", "Pyrimidine nucleobase biosynthetic process", "Pyrimidine nucleobase catabolic process", "Pyrimidine nucleobase metabolic process", "Pyrimidine nucleoside catabolic process", "Pyrimidine nucleoside diphosphate biosynthetic process", "Pyrimidine nucleoside diphosphate metabolic process", "Pyrimidine nucleoside metabolic process", "Pyrimidine nucleoside monophosphate biosynthetic process", "Pyrimidine nucleoside monophosphate metabolic process", "Pyrimidine nucleoside triphosphate biosynthetic process", "Pyrimidine nucleoside triphosphate metabolic process", "Pyrimidine nucleotide catabolic process", "Pyrimidine nucleotide metabolic process", "Pyrimidine ribonucleoside diphosphate metabolic process", "Pyrimidine ribonucleoside monophosphate metabolic process", "Pyrimidine ribonucleoside triphosphate biosynthetic process", "Pyrimidine ribonucleoside triphosphate metabolic process", "Pyrimidine ribonucleotide biosynthetic process", "Pyrimidine ribonucleotide metabolic process", "Pyroptosis", "Pyruvate metabolic process", "Quaternary ammonium group transport", "Quinolinate metabolic process", "Quinone metabolic process", "R loop disassembly", "Rab protein signal transduction", "Rac protein signal transduction", "Radial glial cell differentiation", "Rap protein signal transduction", "Ras protein signal transduction", "Reactive nitrogen species metabolic process", "Reactive oxygen species biosynthetic process", "Reactive oxygen species metabolic process", "Receptor catabolic process", "Receptor clustering", "Receptor diffusion trapping", "Receptor internalization", "Receptor localization to synapse", "Receptor mediated endocytosis", "Receptor mediated endocytosis involved in cholesterol transport", "Receptor metabolic process", "Receptor recycling", "Receptor signaling pathway via stat", "Recognition of apoptotic cell", "Recombinational repair", "Reelin mediated signaling pathway", "Reflex", "Regeneration", "Regionalization", "Regulated exocytosis", "Regulation by virus of viral protein levels in host cell", "Regulation of 3 utr mediated mrna stabilization", "Regulation of actin cytoskeleton reorganization", "Regulation of actin filament based movement", "Regulation of actin filament based process", "Regulation of actin filament bundle assembly", "Regulation of actin filament length", "Regulation of actin filament organization", "Regulation of actin nucleation", "Regulation of action potential", "Regulation of activin receptor signaling pathway", "Regulation of actomyosin structure organization", "Regulation of acute inflammatory response", "Regulation of acute inflammatory response to antigenic stimulus", "Regulation of acyl coa biosynthetic process", "Regulation of adaptive immune response", "Regulation of adenylate cyclase activating g protein coupled receptor signaling pathway", "Regulation of adenylate cyclase activity", "Regulation of adherens junction organization", "Regulation of adipose tissue development", "Regulation of aerobic respiration", "Regulation of alcohol biosynthetic process", "Regulation of alpha beta t cell activation", "Regulation of alpha beta t cell differentiation", "Regulation of alternative mrna splicing via spliceosome", "Regulation of amino acid transmembrane transport", "Regulation of amino acid transport", "Regulation of amyloid beta clearance", "Regulation of amyloid fibril formation", "Regulation of amyloid precursor protein catabolic process", "Regulation of anaphase promoting complex dependent catabolic process", "Regulation of anatomical structure morphogenesis", "Regulation of anatomical structure size", "Regulation of androgen receptor signaling pathway", "Regulation of animal organ formation", "Regulation of animal organ morphogenesis", "Regulation of anion channel activity", "Regulation of anion transmembrane transport", "Regulation of anion transport", "Regulation of anoikis", "Regulation of antigen receptor mediated signaling pathway", "Regulation of apoptotic cell clearance", "Regulation of apoptotic dna fragmentation", "Regulation of apoptotic signaling pathway", "Regulation of appetite", "Regulation of arachidonic acid secretion", "Regulation of arp2 3 complex mediated actin nucleation", "Regulation of aspartic type endopeptidase activity involved in amyloid precursor protein catabolic process", "Regulation of aspartic type peptidase activity", "Regulation of astrocyte differentiation", "Regulation of atp biosynthetic process", "Regulation of atp dependent activity", "Regulation of atp metabolic process", "Regulation of atpase coupled calcium transmembrane transporter activity", "Regulation of atrial cardiac muscle cell membrane repolarization", "Regulation of attachment of spindle microtubules to kinetochore", "Regulation of autophagosome maturation", "Regulation of autophagy", "Regulation of autophagy of mitochondrion", "Regulation of autophagy of mitochondrion in response to mitochondrial depolarization", "Regulation of axon guidance", "Regulation of axonogenesis", "Regulation of b cell activation", "Regulation of b cell apoptotic process", "Regulation of b cell differentiation", "Regulation of b cell mediated immunity", "Regulation of b cell proliferation", "Regulation of b cell receptor signaling pathway", "Regulation of barbed end actin filament capping", "Regulation of behavior", "Regulation of bicellular tight junction assembly", "Regulation of bile acid biosynthetic process", "Regulation of bile acid metabolic process", "Regulation of bile acid secretion", "Regulation of binding", "Regulation of biological process involved in symbiotic interaction", "Regulation of biomineralization", "Regulation of blood brain barrier permeability", "Regulation of blood circulation", "Regulation of blood pressure", "Regulation of bmp signaling pathway", "Regulation of body fluid levels", "Regulation of bone mineralization", "Regulation of bone remodeling", "Regulation of bone resorption", "Regulation of branching involved in lung morphogenesis", "Regulation of branching morphogenesis of a nerve", "Regulation of brown fat cell differentiation", "Regulation of calcineurin mediated signaling", "Regulation of calcium ion dependent exocytosis", "Regulation of calcium ion export across plasma membrane", "Regulation of calcium ion import", "Regulation of calcium ion transmembrane transport", "Regulation of calcium ion transmembrane transporter activity", "Regulation of calcium ion transport", "Regulation of calcium ion transport into cytosol", "Regulation of calcium mediated signaling", "Regulation of camp dependent protein kinase activity", "Regulation of camp mediated signaling", "Regulation of canonical wnt signaling pathway", "Regulation of carbohydrate biosynthetic process", "Regulation of carbohydrate catabolic process", "Regulation of carbohydrate metabolic process", "Regulation of cardiac conduction", "Regulation of cardiac muscle adaptation", "Regulation of cardiac muscle cell action potential", "Regulation of cardiac muscle cell action potential involved in regulation of contraction", "Regulation of cardiac muscle cell membrane potential", "Regulation of cardiac muscle cell membrane repolarization", "Regulation of cardiac muscle cell proliferation", "Regulation of cardiac muscle contraction", "Regulation of cardiac muscle contraction by calcium ion signaling", "Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion", "Regulation of cardioblast differentiation", "Regulation of cardiocyte differentiation", "Regulation of cartilage development", "Regulation of catabolic process", "Regulation of catecholamine metabolic process", "Regulation of cation channel activity", "Regulation of cation transmembrane transport", "Regulation of caveolin mediated endocytosis", "Regulation of cd4 positive alpha beta t cell activation", "Regulation of cd4 positive alpha beta t cell differentiation", "Regulation of cd40 signaling pathway", "Regulation of cd8 positive alpha beta t cell activation", "Regulation of cd8 positive alpha beta t cell differentiation", "Regulation of cell activation", "Regulation of cell adhesion", "Regulation of cell adhesion mediated by integrin", "Regulation of cell aging", "Regulation of cell cell adhesion", "Regulation of cell cell adhesion mediated by cadherin", "Regulation of cell cell adhesion mediated by integrin", "Regulation of cell communication by electrical coupling", "Regulation of cell communication by electrical coupling involved in cardiac conduction", "Regulation of cell cycle", "Regulation of cell cycle checkpoint", "Regulation of cell cycle g1 s phase transition", "Regulation of cell cycle g2 m phase transition", "Regulation of cell cycle phase transition", "Regulation of cell cycle process", "Regulation of cell death", "Regulation of cell development", "Regulation of cell differentiation", "Regulation of cell division", "Regulation of cell growth involved in cardiac muscle cell development", "Regulation of cell junction assembly", "Regulation of cell killing", "Regulation of cell matrix adhesion", "Regulation of cell maturation", "Regulation of cell migration involved in sprouting angiogenesis", "Regulation of cell morphogenesis", "Regulation of cell morphogenesis involved in differentiation", "Regulation of cell population proliferation", "Regulation of cell projection assembly", "Regulation of cell projection organization", "Regulation of cell projection size", "Regulation of cell shape", "Regulation of cell size", "Regulation of cell substrate adhesion", "Regulation of cell substrate junction organization", "Regulation of cellular amide metabolic process", "Regulation of cellular amine metabolic process", "Regulation of cellular amino acid metabolic process", "Regulation of cellular carbohydrate catabolic process", "Regulation of cellular carbohydrate metabolic process", "Regulation of cellular component biogenesis", "Regulation of cellular component movement", "Regulation of cellular component size", "Regulation of cellular extravasation", "Regulation of cellular ketone metabolic process", "Regulation of cellular localization", "Regulation of cellular macromolecule biosynthetic process", "Regulation of cellular ph", "Regulation of cellular ph reduction", "Regulation of cellular protein catabolic process", "Regulation of cellular respiration", "Regulation of cellular response to growth factor stimulus", "Regulation of cellular response to heat", "Regulation of cellular response to hypoxia", "Regulation of cellular response to insulin stimulus", "Regulation of cellular response to osmotic stress", "Regulation of cellular response to stress", "Regulation of cellular response to transforming growth factor beta stimulus", "Regulation of cellular response to vascular endothelial growth factor stimulus", "Regulation of centriole replication", "Regulation of centrosome cycle", "Regulation of chaperone mediated autophagy", "Regulation of chemokine mediated signaling pathway", "Regulation of chemotaxis", "Regulation of chloride transport", "Regulation of cholesterol biosynthetic process", "Regulation of cholesterol efflux", "Regulation of cholesterol esterification", "Regulation of cholesterol metabolic process", "Regulation of chondrocyte differentiation", "Regulation of chromatin assembly", "Regulation of chromatin assembly or disassembly", "Regulation of chromatin binding", "Regulation of chromatin organization", "Regulation of chromosome condensation", "Regulation of chromosome organization", "Regulation of chromosome segregation", "Regulation of chromosome separation", "Regulation of cilium assembly", "Regulation of cilium beat frequency", "Regulation of cilium beat frequency involved in ciliary motility", "Regulation of cilium dependent cell motility", "Regulation of cilium movement", "Regulation of circadian rhythm", "Regulation of clathrin dependent endocytosis", "Regulation of coagulation", "Regulation of collagen fibril organization", "Regulation of collagen metabolic process", "Regulation of collateral sprouting", "Regulation of complement activation", "Regulation of complement dependent cytotoxicity", "Regulation of connective tissue replacement", "Regulation of core promoter binding", "Regulation of cyclase activity", "Regulation of cyclic nucleotide phosphodiesterase activity", "Regulation of cyclin dependent protein kinase activity", "Regulation of cysteine type endopeptidase activity", "Regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway", "Regulation of cysteine type endopeptidase activity involved in execution phase of apoptosis", "Regulation of cytokinesis", "Regulation of cytoplasmic mrna processing body assembly", "Regulation of cytoplasmic translation", "Regulation of cytoplasmic translational elongation", "Regulation of cytoplasmic translational initiation", "Regulation of cytoplasmic transport", "Regulation of cytoskeleton organization", "Regulation of cytosolic calcium ion concentration", "Regulation of deacetylase activity", "Regulation of defense response", "Regulation of defense response to bacterium", "Regulation of defense response to virus", "Regulation of defense response to virus by host", "Regulation of delayed rectifier potassium channel activity", "Regulation of dendrite development", "Regulation of dendrite extension", "Regulation of dendrite morphogenesis", "Regulation of dendritic cell chemotaxis", "Regulation of dendritic cell differentiation", "Regulation of dendritic spine development", "Regulation of dendritic spine maintenance", "Regulation of dendritic spine morphogenesis", "Regulation of deoxyribonuclease activity", "Regulation of dephosphorylation", "Regulation of development heterochronic", "Regulation of developmental growth", "Regulation of digestive system process", "Regulation of dna binding", "Regulation of dna binding transcription factor activity", "Regulation of dna biosynthetic process", "Regulation of dna catabolic process", "Regulation of dna damage checkpoint", "Regulation of dna damage response signal transduction by p53 class mediator", "Regulation of dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator", "Regulation of dna demethylation", "Regulation of dna dependent dna replication", "Regulation of dna dependent dna replication initiation", "Regulation of dna directed dna polymerase activity", "Regulation of dna duplex unwinding", "Regulation of dna helicase activity", "Regulation of dna ligation", "Regulation of dna metabolic process", "Regulation of dna methylation", "Regulation of dna methylation dependent heterochromatin assembly", "Regulation of dna primase activity", "Regulation of dna recombination", "Regulation of dna repair", "Regulation of dna replication", "Regulation of dna strand elongation", "Regulation of dna templated transcription elongation", "Regulation of dna templated transcription in response to stress", "Regulation of dna templated transcription initiation", "Regulation of dna topoisomerase atp hydrolyzing activity", "Regulation of dopamine receptor signaling pathway", "Regulation of dopamine uptake involved in synaptic transmission", "Regulation of double strand break repair", "Regulation of double strand break repair via homologous recombination", "Regulation of double strand break repair via nonhomologous end joining", "Regulation of early endosome to late endosome transport", "Regulation of eating behavior", "Regulation of electron transfer activity", "Regulation of embryonic development", "Regulation of endocrine process", "Regulation of endocytic recycling", "Regulation of endocytosis", "Regulation of endodeoxyribonuclease activity", "Regulation of endodermal cell differentiation", "Regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway", "Regulation of endoplasmic reticulum tubular network organization", "Regulation of endoplasmic reticulum unfolded protein response", "Regulation of endothelial cell chemotaxis", "Regulation of endothelial cell development", "Regulation of endothelial cell differentiation", "Regulation of endothelial cell migration", "Regulation of entry of bacterium into host cell", "Regulation of epidermal growth factor activated receptor activity", "Regulation of epidermis development", "Regulation of epithelial cell apoptotic process", "Regulation of epithelial cell differentiation", "Regulation of epithelial cell differentiation involved in kidney development", "Regulation of epithelial cell migration", "Regulation of epithelial cell proliferation involved in lung morphogenesis", "Regulation of epithelial to mesenchymal transition", "Regulation of er associated ubiquitin dependent protein catabolic process", "Regulation of er to golgi vesicle mediated transport", "Regulation of erad pathway", "Regulation of erbb signaling pathway", "Regulation of erythrocyte differentiation", "Regulation of establishment of planar polarity", "Regulation of establishment of protein localization", "Regulation of establishment of protein localization to chromosome", "Regulation of establishment of protein localization to mitochondrion", "Regulation of establishment or maintenance of cell polarity", "Regulation of excretion", "Regulation of execution phase of apoptosis", "Regulation of exit from mitosis", "Regulation of exocytosis", "Regulation of exosomal secretion", "Regulation of extent of cell growth", "Regulation of extracellular matrix assembly", "Regulation of extracellular matrix disassembly", "Regulation of extracellular matrix organization", "Regulation of extrinsic apoptotic signaling pathway", "Regulation of extrinsic apoptotic signaling pathway in absence of ligand", "Regulation of extrinsic apoptotic signaling pathway via death domain receptors", "Regulation of fat cell differentiation", "Regulation of fat cell proliferation", "Regulation of fatty acid beta oxidation", "Regulation of fatty acid biosynthetic process", "Regulation of fatty acid metabolic process", "Regulation of fatty acid oxidation", "Regulation of fatty acid transport", "Regulation of fc gamma receptor signaling pathway involved in phagocytosis", "Regulation of fc receptor mediated stimulatory signaling pathway", "Regulation of feeding behavior", "Regulation of fertilization", "Regulation of fibroblast growth factor receptor signaling pathway", "Regulation of fibroblast migration", "Regulation of filopodium assembly", "Regulation of focal adhesion disassembly", "Regulation of g protein coupled receptor signaling pathway", "Regulation of g0 to g1 transition", "Regulation of gamma aminobutyric acid secretion", "Regulation of gastrulation", "Regulation of gene expression by genomic imprinting", "Regulation of gene expression epigenetic", "Regulation of gene silencing by rna", "Regulation of generation of precursor metabolites and energy", "Regulation of genetic imprinting", "Regulation of germ cell proliferation", "Regulation of glial cell apoptotic process", "Regulation of glial cell differentiation", "Regulation of glial cell migration", "Regulation of glial cell proliferation", "Regulation of gliogenesis", "Regulation of glucagon secretion", "Regulation of glucan biosynthetic process", "Regulation of glucocorticoid biosynthetic process", "Regulation of glucocorticoid metabolic process", "Regulation of glucocorticoid receptor signaling pathway", "Regulation of glucocorticoid secretion", "Regulation of gluconeogenesis", "Regulation of glucose import", "Regulation of glucose metabolic process", "Regulation of glucose transmembrane transport", "Regulation of glucosylceramidase activity", "Regulation of glutamate receptor clustering", "Regulation of glutamate secretion", "Regulation of glycogen catabolic process", "Regulation of glycogen metabolic process", "Regulation of glycolytic process", "Regulation of glycoprotein metabolic process", "Regulation of golgi organization", "Regulation of golgi to plasma membrane protein transport", "Regulation of gonad development", "Regulation of granulocyte chemotaxis", "Regulation of growth", "Regulation of gtp binding", "Regulation of gtpase activity", "Regulation of guanyl nucleotide exchange factor activity", "Regulation of hair cycle", "Regulation of hair follicle development", "Regulation of heart contraction", "Regulation of heart growth", "Regulation of heart rate", "Regulation of heart rate by cardiac conduction", "Regulation of heart rate by chemical signal", "Regulation of helicase activity", "Regulation of hematopoietic progenitor cell differentiation", "Regulation of hematopoietic stem cell differentiation", "Regulation of hematopoietic stem cell proliferation", "Regulation of hemoglobin biosynthetic process", "Regulation of hemopoiesis", "Regulation of hepatic stellate cell activation", "Regulation of hepatocyte apoptotic process", "Regulation of heterotypic cell cell adhesion", "Regulation of hexokinase activity", "Regulation of high voltage gated calcium channel activity", "Regulation of hippo signaling", "Regulation of histamine secretion by mast cell", "Regulation of histone deacetylase activity", "Regulation of histone deacetylation", "Regulation of histone h2b ubiquitination", "Regulation of histone h3 k14 acetylation", "Regulation of histone h3 k27 methylation", "Regulation of histone h3 k36 methylation", "Regulation of histone h3 k4 methylation", "Regulation of histone h3 k9 methylation", "Regulation of histone h3 k9 trimethylation", "Regulation of histone h4 acetylation", "Regulation of histone h4 k16 acetylation", "Regulation of histone methylation", "Regulation of histone modification", "Regulation of histone phosphorylation", "Regulation of histone ubiquitination", "Regulation of homotypic cell cell adhesion", "Regulation of hormone biosynthetic process", "Regulation of hormone levels", "Regulation of hormone metabolic process", "Regulation of hormone secretion", "Regulation of humoral immune response", "Regulation of hyaluronan biosynthetic process", "Regulation of hydrogen peroxide biosynthetic process", "Regulation of hydrogen peroxide mediated programmed cell death", "Regulation of hydrogen peroxide metabolic process", "Regulation of hydrolase activity", "Regulation of i kappab phosphorylation", "Regulation of icosanoid secretion", "Regulation of immune effector process", "Regulation of immune response", "Regulation of immune system process", "Regulation of immunoglobulin production", "Regulation of inclusion body assembly", "Regulation of inflammatory response", "Regulation of inflammatory response to antigenic stimulus", "Regulation of innate immune response", "Regulation of inositol 1 4 5 trisphosphate sensitive calcium release channel activity", "Regulation of insulin like growth factor receptor signaling pathway", "Regulation of insulin receptor signaling pathway", "Regulation of insulin secretion", "Regulation of insulin secretion involved in cellular response to glucose stimulus", "Regulation of integrin activation", "Regulation of integrin mediated signaling pathway", "Regulation of interleukin 1 mediated signaling pathway", "Regulation of interleukin 6 mediated signaling pathway", "Regulation of intestinal absorption", "Regulation of intracellular estrogen receptor signaling pathway", "Regulation of intracellular lipid transport", "Regulation of intracellular protein transport", "Regulation of intracellular signal transduction", "Regulation of intracellular steroid hormone receptor signaling pathway", "Regulation of intracellular transport", "Regulation of intrinsic apoptotic signaling pathway", "Regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage", "Regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator", "Regulation of intrinsic apoptotic signaling pathway in response to osmotic stress", "Regulation of inward rectifier potassium channel activity", "Regulation of ion transmembrane transport", "Regulation of ion transport", "Regulation of ire1 mediated unfolded protein response", "Regulation of isomerase activity", "Regulation of isotype switching", "Regulation of jnk cascade", "Regulation of jun kinase activity", "Regulation of keratinocyte differentiation", "Regulation of keratinocyte migration", "Regulation of keratinocyte proliferation", "Regulation of kidney development", "Regulation of l glutamate import across plasma membrane", "Regulation of lamellipodium assembly", "Regulation of lamellipodium morphogenesis", "Regulation of lamellipodium organization", "Regulation of leukocyte apoptotic process", "Regulation of leukocyte chemotaxis", "Regulation of leukocyte degranulation", "Regulation of leukocyte differentiation", "Regulation of leukocyte mediated cytotoxicity", "Regulation of leukocyte mediated immunity", "Regulation of leukocyte migration", "Regulation of leukocyte proliferation", "Regulation of ligase activity", "Regulation of lipase activity", "Regulation of lipid biosynthetic process", "Regulation of lipid catabolic process", "Regulation of lipid kinase activity", "Regulation of lipid localization", "Regulation of lipid metabolic process", "Regulation of lipid storage", "Regulation of lipid transport", "Regulation of lipophagy", "Regulation of lipopolysaccharide mediated signaling pathway", "Regulation of lipoprotein lipase activity", "Regulation of lipoprotein metabolic process", "Regulation of lipoprotein particle clearance", "Regulation of locomotion involved in locomotory behavior", "Regulation of long chain fatty acid import across plasma membrane", "Regulation of long chain fatty acid import into cell", "Regulation of long term neuronal synaptic plasticity", "Regulation of long term synaptic depression", "Regulation of long term synaptic potentiation", "Regulation of low density lipoprotein particle clearance", "Regulation of lyase activity", "Regulation of lymphocyte activation", "Regulation of lymphocyte apoptotic process", "Regulation of lymphocyte chemotaxis", "Regulation of lymphocyte differentiation", "Regulation of lymphocyte mediated immunity", "Regulation of lymphocyte migration", "Regulation of lymphoid progenitor cell differentiation", "Regulation of lysosomal lumen ph", "Regulation of lysosomal protein catabolic process", "Regulation of lysosome organization", "Regulation of macroautophagy", "Regulation of macrophage activation", "Regulation of macrophage apoptotic process", "Regulation of macrophage chemotaxis", "Regulation of macrophage differentiation", "Regulation of macrophage migration", "Regulation of macrophage proliferation", "Regulation of maintenance of sister chromatid cohesion", "Regulation of male gonad development", "Regulation of mammary gland epithelial cell proliferation", "Regulation of map kinase activity", "Regulation of mast cell activation", "Regulation of mast cell activation involved in immune response", "Regulation of mast cell chemotaxis", "Regulation of matrix metallopeptidase secretion", "Regulation of mda 5 signaling pathway", "Regulation of megakaryocyte differentiation", "Regulation of meiotic cell cycle", "Regulation of meiotic nuclear division", "Regulation of membrane depolarization", "Regulation of membrane depolarization during action potential", "Regulation of membrane depolarization during cardiac muscle cell action potential", "Regulation of membrane invagination", "Regulation of membrane lipid distribution", "Regulation of membrane permeability", "Regulation of membrane potential", "Regulation of membrane protein ectodomain proteolysis", "Regulation of membrane repolarization", "Regulation of membrane repolarization during action potential", "Regulation of membrane repolarization during cardiac muscle cell action potential", "Regulation of membrane tubulation", "Regulation of mesenchymal cell proliferation", "Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis", "Regulation of mesoderm development", "Regulation of metal ion transport", "Regulation of metalloendopeptidase activity", "Regulation of metallopeptidase activity", "Regulation of metanephros development", "Regulation of metaphase plate congression", "Regulation of microglial cell activation", "Regulation of microtubule based movement", "Regulation of microtubule based process", "Regulation of microtubule binding", "Regulation of microtubule cytoskeleton organization", "Regulation of microtubule depolymerization", "Regulation of microtubule nucleation", "Regulation of microtubule polymerization", "Regulation of microtubule polymerization or depolymerization", "Regulation of microvillus assembly", "Regulation of microvillus length", "Regulation of microvillus organization", "Regulation of mirna catabolic process", "Regulation of mirna metabolic process", "Regulation of mirna transcription", "Regulation of mitochondrial atp synthesis coupled electron transport", "Regulation of mitochondrial dna replication", "Regulation of mitochondrial electron transport nadh to ubiquinone", "Regulation of mitochondrial fission", "Regulation of mitochondrial fusion", "Regulation of mitochondrial gene expression", "Regulation of mitochondrial membrane permeability", "Regulation of mitochondrial membrane permeability involved in apoptotic process", "Regulation of mitochondrial membrane potential", "Regulation of mitochondrial mrna stability", "Regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "Regulation of mitochondrial rna catabolic process", "Regulation of mitochondrion organization", "Regulation of mitophagy", "Regulation of mitotic cell cycle", "Regulation of mitotic cell cycle phase transition", "Regulation of mitotic cell cycle spindle assembly checkpoint", "Regulation of mitotic centrosome separation", "Regulation of mitotic cytokinesis", "Regulation of mitotic nuclear division", "Regulation of mitotic recombination", "Regulation of mitotic sister chromatid segregation", "Regulation of mitotic spindle assembly", "Regulation of modification of postsynaptic structure", "Regulation of modification of synaptic structure", "Regulation of monocyte chemotaxis", "Regulation of monocyte differentiation", "Regulation of monocyte extravasation", "Regulation of mononuclear cell migration", "Regulation of monooxygenase activity", "Regulation of morphogenesis of a branching structure", "Regulation of morphogenesis of an epithelium", "Regulation of motor neuron apoptotic process", "Regulation of mrna 3 end processing", "Regulation of mrna binding", "Regulation of mrna catabolic process", "Regulation of mrna export from nucleus", "Regulation of mrna metabolic process", "Regulation of mrna polyadenylation", "Regulation of mrna processing", "Regulation of mrna splicing via spliceosome", "Regulation of multicellular organism growth", "Regulation of multicellular organismal development", "Regulation of muscle adaptation", "Regulation of muscle cell differentiation", "Regulation of muscle contraction", "Regulation of muscle hypertrophy", "Regulation of muscle organ development", "Regulation of muscle system process", "Regulation of myelination", "Regulation of myeloid cell apoptotic process", "Regulation of myeloid cell differentiation", "Regulation of myeloid leukocyte differentiation", "Regulation of myeloid leukocyte mediated immunity", "Regulation of myoblast differentiation", "Regulation of myoblast fusion", "Regulation of myosin light chain phosphatase activity", "Regulation of myotube differentiation", "Regulation of nad p h oxidase activity", "Regulation of nadp metabolic process", "Regulation of natural killer cell activation", "Regulation of natural killer cell mediated immunity", "Regulation of necrotic cell death", "Regulation of nervous system development", "Regulation of nervous system process", "Regulation of neural precursor cell proliferation", "Regulation of neuroblast proliferation", "Regulation of neurogenesis", "Regulation of neuromuscular junction development", "Regulation of neuron differentiation", "Regulation of neuron migration", "Regulation of neuron projection arborization", "Regulation of neuron projection development", "Regulation of neuron projection regeneration", "Regulation of neuronal action potential", "Regulation of neuronal synaptic plasticity", "Regulation of neurotransmitter levels", "Regulation of neurotransmitter receptor activity", "Regulation of neurotransmitter transport", "Regulation of neurotransmitter uptake", "Regulation of neurotrophin trk receptor signaling pathway", "Regulation of neutrophil chemotaxis", "Regulation of neutrophil migration", "Regulation of nik nf kappab signaling", "Regulation of nitric oxide metabolic process", "Regulation of nitric oxide synthase activity", "Regulation of nk t cell activation", "Regulation of nk t cell differentiation", "Regulation of nmda receptor activity", "Regulation of non motile cilium assembly", "Regulation of notch signaling pathway", "Regulation of nuclear cell cycle dna replication", "Regulation of nuclear division", "Regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay", "Regulation of nuclear transcribed mrna catabolic process nonsense mediated decay", "Regulation of nuclear transcribed mrna poly a tail shortening", "Regulation of nuclease activity", "Regulation of nucleobase containing compound transport", "Regulation of nucleocytoplasmic transport", "Regulation of nucleotide binding oligomerization domain containing 2 signaling pathway", "Regulation of nucleotide binding oligomerization domain containing signaling pathway", "Regulation of nucleotide biosynthetic process", "Regulation of nucleotide metabolic process", "Regulation of oligodendrocyte differentiation", "Regulation of oocyte maturation", "Regulation of organ growth", "Regulation of organelle assembly", "Regulation of organelle organization", "Regulation of organelle transport along microtubule", "Regulation of organic acid transport", "Regulation of ossification", "Regulation of osteoblast differentiation", "Regulation of osteoblast proliferation", "Regulation of osteoclast differentiation", "Regulation of oxidative phosphorylation", "Regulation of oxidative stress induced cell death", "Regulation of oxidative stress induced intrinsic apoptotic signaling pathway", "Regulation of oxidoreductase activity", "Regulation of p38mapk cascade", "Regulation of pancreatic juice secretion", "Regulation of pattern recognition receptor signaling pathway", "Regulation of peptidase activity", "Regulation of peptide transport", "Regulation of peptidyl lysine acetylation", "Regulation of peptidyl serine phosphorylation", "Regulation of peptidyl serine phosphorylation of stat protein", "Regulation of peptidyl threonine phosphorylation", "Regulation of peptidyl tyrosine phosphorylation", "Regulation of perk mediated unfolded protein response", "Regulation of peroxisome proliferator activated receptor signaling pathway", "Regulation of ph", "Regulation of phagocytosis", "Regulation of phenotypic switching", "Regulation of phosphatase activity", "Regulation of phosphatidylcholine biosynthetic process", "Regulation of phosphatidylcholine metabolic process", "Regulation of phosphatidylinositol 3 kinase activity", "Regulation of phosphatidylinositol 3 kinase signaling", "Regulation of phospholipase a2 activity", "Regulation of phospholipase activity", "Regulation of phospholipase c activity", "Regulation of phospholipid biosynthetic process", "Regulation of phospholipid catabolic process", "Regulation of phospholipid metabolic process", "Regulation of phosphoprotein phosphatase activity", "Regulation of phosphorus metabolic process", "Regulation of pigmentation", "Regulation of pinocytosis", "Regulation of plasma lipoprotein particle levels", "Regulation of plasma membrane organization", "Regulation of plasminogen activation", "Regulation of platelet activation", "Regulation of platelet aggregation", "Regulation of platelet derived growth factor receptor beta signaling pathway", "Regulation of platelet derived growth factor receptor signaling pathway", "Regulation of podosome assembly", "Regulation of polysaccharide metabolic process", "Regulation of post translational protein modification", "Regulation of postsynapse organization", "Regulation of postsynaptic density organization", "Regulation of postsynaptic membrane neurotransmitter receptor levels", "Regulation of postsynaptic membrane potential", "Regulation of postsynaptic neurotransmitter receptor internalization", "Regulation of potassium ion export across plasma membrane", "Regulation of potassium ion import", "Regulation of potassium ion transmembrane transporter activity", "Regulation of potassium ion transport", "Regulation of presynapse organization", "Regulation of presynaptic cytosolic calcium ion concentration", "Regulation of pro b cell differentiation", "Regulation of production of molecular mediator of immune response", "Regulation of production of small rna involved in gene silencing by rna", "Regulation of programmed necrotic cell death", "Regulation of prostaglandin secretion", "Regulation of proteasomal protein catabolic process", "Regulation of proteasomal ubiquitin dependent protein catabolic process", "Regulation of protein acetylation", "Regulation of protein adp ribosylation", "Regulation of protein autophosphorylation", "Regulation of protein autoubiquitination", "Regulation of protein binding", "Regulation of protein catabolic process", "Regulation of protein catabolic process in the vacuole", "Regulation of protein complex stability", "Regulation of protein containing complex assembly", "Regulation of protein containing complex disassembly", "Regulation of protein deacetylation", "Regulation of protein dephosphorylation", "Regulation of protein depolymerization", "Regulation of protein deubiquitination", "Regulation of protein exit from endoplasmic reticulum", "Regulation of protein export from nucleus", "Regulation of protein folding", "Regulation of protein glycosylation", "Regulation of protein import", "Regulation of protein k63 linked ubiquitination", "Regulation of protein kinase a signaling", "Regulation of protein kinase activity", "Regulation of protein kinase c signaling", "Regulation of protein lipidation", "Regulation of protein localization", "Regulation of protein localization to cell cortex", "Regulation of protein localization to cell periphery", "Regulation of protein localization to cell surface", "Regulation of protein localization to centrosome", "Regulation of protein localization to chromatin", "Regulation of protein localization to chromosome telomeric region", "Regulation of protein localization to cilium", "Regulation of protein localization to endosome", "Regulation of protein localization to membrane", "Regulation of protein localization to nucleolus", "Regulation of protein localization to nucleus", "Regulation of protein localization to plasma membrane", "Regulation of protein maturation", "Regulation of protein modification by small protein conjugation or removal", "Regulation of protein modification process", "Regulation of protein monoubiquitination", "Regulation of protein neddylation", "Regulation of protein phosphorylation", "Regulation of protein polymerization", "Regulation of protein polyubiquitination", "Regulation of protein secretion", "Regulation of protein serine threonine kinase activity", "Regulation of protein stability", "Regulation of protein sumoylation", "Regulation of protein targeting", "Regulation of protein targeting to membrane", "Regulation of protein tyrosine kinase activity", "Regulation of protein tyrosine phosphatase activity", "Regulation of proteolysis", "Regulation of proton transport", "Regulation of rac protein signal transduction", "Regulation of ras protein signal transduction", "Regulation of reactive oxygen species biosynthetic process", "Regulation of reactive oxygen species metabolic process", "Regulation of receptor binding", "Regulation of receptor catabolic process", "Regulation of receptor clustering", "Regulation of receptor internalization", "Regulation of receptor localization to synapse", "Regulation of receptor mediated endocytosis", "Regulation of receptor mediated endocytosis involved in cholesterol transport", "Regulation of receptor recycling", "Regulation of receptor signaling pathway via stat", "Regulation of regulated secretory pathway", "Regulation of relaxation of muscle", "Regulation of release of cytochrome c from mitochondria", "Regulation of release of sequestered calcium ion into cytosol", "Regulation of removal of superoxide radicals", "Regulation of renal system process", "Regulation of reproductive process", "Regulation of respiratory burst", "Regulation of respiratory gaseous exchange", "Regulation of respiratory gaseous exchange by nervous system process", "Regulation of respiratory system process", "Regulation of response to biotic stimulus", "Regulation of response to cytokine stimulus", "Regulation of response to dna damage stimulus", "Regulation of response to endoplasmic reticulum stress", "Regulation of response to external stimulus", "Regulation of response to extracellular stimulus", "Regulation of response to food", "Regulation of response to interferon gamma", "Regulation of response to osmotic stress", "Regulation of response to oxidative stress", "Regulation of response to reactive oxygen species", "Regulation of response to stress", "Regulation of response to tumor cell", "Regulation of response to wounding", "Regulation of retinal ganglion cell axon guidance", "Regulation of retinoic acid receptor signaling pathway", "Regulation of retrograde protein transport er to cytosol", "Regulation of retrograde transport endosome to golgi", "Regulation of rho dependent protein serine threonine kinase activity", "Regulation of rho protein signal transduction", "Regulation of rhodopsin mediated signaling pathway", "Regulation of ribonuclease activity", "Regulation of ribosome biogenesis", "Regulation of rig i signaling pathway", "Regulation of rna binding", "Regulation of rna export from nucleus", "Regulation of rna polymerase ii regulatory region sequence specific dna binding", "Regulation of rna polymerase ii transcription preinitiation complex assembly", "Regulation of rna splicing", "Regulation of rrna processing", "Regulation of ruffle assembly", "Regulation of ryanodine sensitive calcium release channel activity", "Regulation of secondary heart field cardioblast proliferation", "Regulation of secondary metabolic process", "Regulation of secretion", "Regulation of sequestering of triglyceride", "Regulation of sequestering of zinc ion", "Regulation of short term neuronal synaptic plasticity", "Regulation of signal transduction by p53 class mediator", "Regulation of signaling receptor activity", "Regulation of sister chromatid cohesion", "Regulation of skeletal muscle adaptation", "Regulation of skeletal muscle cell differentiation", "Regulation of skeletal muscle contraction", "Regulation of skeletal muscle contraction by calcium ion signaling", "Regulation of skeletal muscle tissue development", "Regulation of smad protein complex assembly", "Regulation of smad protein signal transduction", "Regulation of small gtpase mediated signal transduction", "Regulation of small molecule metabolic process", "Regulation of smooth muscle cell chemotaxis", "Regulation of smooth muscle cell differentiation", "Regulation of smooth muscle contraction", "Regulation of smoothened signaling pathway", "Regulation of smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Regulation of snrna transcription by rna polymerase ii", "Regulation of sodium ion transmembrane transport", "Regulation of sodium ion transport", "Regulation of sodium proton antiporter activity", "Regulation of somatic stem cell population maintenance", "Regulation of sphingolipid biosynthetic process", "Regulation of spindle assembly", "Regulation of spindle organization", "Regulation of spontaneous synaptic transmission", "Regulation of sprouting angiogenesis", "Regulation of srebp signaling pathway", "Regulation of stem cell differentiation", "Regulation of stem cell population maintenance", "Regulation of stem cell proliferation", "Regulation of steroid biosynthetic process", "Regulation of steroid hormone biosynthetic process", "Regulation of steroid hormone secretion", "Regulation of steroid metabolic process", "Regulation of sterol transport", "Regulation of stress activated protein kinase signaling cascade", "Regulation of stress granule assembly", "Regulation of striated muscle cell differentiation", "Regulation of striated muscle contraction", "Regulation of substrate adhesion dependent cell spreading", "Regulation of sulfur metabolic process", "Regulation of superoxide anion generation", "Regulation of superoxide dismutase activity", "Regulation of superoxide metabolic process", "Regulation of supramolecular fiber organization", "Regulation of synapse assembly", "Regulation of synapse maturation", "Regulation of synapse structural plasticity", "Regulation of synapse structure or activity", "Regulation of synaptic plasticity", "Regulation of synaptic transmission dopaminergic", "Regulation of synaptic transmission gabaergic", "Regulation of synaptic transmission glutamatergic", "Regulation of synaptic vesicle clustering", "Regulation of synaptic vesicle cycle", "Regulation of synaptic vesicle endocytosis", "Regulation of synaptic vesicle exocytosis", "Regulation of synaptic vesicle priming", "Regulation of synaptic vesicle recycling", "Regulation of syncytium formation by plasma membrane fusion", "Regulation of system process", "Regulation of systemic arterial blood pressure", "Regulation of systemic arterial blood pressure by endothelin", "Regulation of systemic arterial blood pressure by hormone", "Regulation of systemic arterial blood pressure by norepinephrine epinephrine", "Regulation of systemic arterial blood pressure mediated by a chemical signal", "Regulation of t cell activation", "Regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell", "Regulation of t cell apoptotic process", "Regulation of t cell chemotaxis", "Regulation of t cell differentiation", "Regulation of t cell differentiation in thymus", "Regulation of t cell mediated cytotoxicity", "Regulation of t cell mediated immune response to tumor cell", "Regulation of t cell mediated immunity", "Regulation of t cell migration", "Regulation of t cell proliferation", "Regulation of t cell receptor signaling pathway", "Regulation of t circle formation", "Regulation of t helper 1 cell differentiation", "Regulation of t helper 1 type immune response", "Regulation of t helper 2 cell differentiation", "Regulation of t helper cell differentiation", "Regulation of tau protein kinase activity", "Regulation of telomerase activity", "Regulation of telomere capping", "Regulation of telomere maintenance", "Regulation of telomere maintenance via telomere lengthening", "Regulation of tetrapyrrole metabolic process", "Regulation of the force of heart contraction", "Regulation of thymocyte apoptotic process", "Regulation of tissue remodeling", "Regulation of tolerance induction", "Regulation of toll like receptor 3 signaling pathway", "Regulation of toll like receptor 4 signaling pathway", "Regulation of toll like receptor 7 signaling pathway", "Regulation of toll like receptor 9 signaling pathway", "Regulation of toll like receptor signaling pathway", "Regulation of tooth mineralization", "Regulation of tor signaling", "Regulation of torc2 signaling", "Regulation of trail activated apoptotic signaling pathway", "Regulation of trans synaptic signaling", "Regulation of transcription by glucose", "Regulation of transcription by rna polymerase i", "Regulation of transcription by rna polymerase iii", "Regulation of transcription elongation from rna polymerase ii promoter", "Regulation of transcription from rna polymerase ii promoter in response to hypoxia", "Regulation of transcription from rna polymerase ii promoter in response to oxidative stress", "Regulation of transcription from rna polymerase ii promoter involved in heart development", "Regulation of transcription involved in g1 s transition of mitotic cell cycle", "Regulation of transcription of nucleolar large rrna by rna polymerase i", "Regulation of transcription regulatory region dna binding", "Regulation of transferase activity", "Regulation of transforming growth factor beta activation", "Regulation of transforming growth factor beta1 production", "Regulation of translation at synapse modulating synaptic transmission", "Regulation of translation in response to endoplasmic reticulum stress", "Regulation of translation in response to stress", "Regulation of translation initiation in response to endoplasmic reticulum stress", "Regulation of translational elongation", "Regulation of translational fidelity", "Regulation of translational initiation", "Regulation of translational initiation by eif2 alpha phosphorylation", "Regulation of translational initiation in response to stress", "Regulation of translational termination", "Regulation of transmembrane receptor protein serine threonine kinase signaling pathway", "Regulation of transmembrane transport", "Regulation of transmission of nerve impulse", "Regulation of transport", "Regulation of transporter activity", "Regulation of transposition", "Regulation of triglyceride biosynthetic process", "Regulation of triglyceride metabolic process", "Regulation of tube size", "Regulation of tumor necrosis factor mediated signaling pathway", "Regulation of type i interferon mediated signaling pathway", "Regulation of ubiquitin dependent protein catabolic process", "Regulation of ubiquitin protein ligase activity", "Regulation of ubiquitin protein transferase activity", "Regulation of ubiquitin specific protease activity", "Regulation of unsaturated fatty acid biosynthetic process", "Regulation of urine volume", "Regulation of vacuole organization", "Regulation of vascular associated smooth muscle cell differentiation", "Regulation of vascular associated smooth muscle contraction", "Regulation of vascular endothelial growth factor receptor signaling pathway", "Regulation of vascular permeability", "Regulation of vascular wound healing", "Regulation of vasculature development", "Regulation of vasculogenesis", "Regulation of vasoconstriction", "Regulation of ventricular cardiac muscle cell action potential", "Regulation of ventricular cardiac muscle cell membrane depolarization", "Regulation of very low density lipoprotein particle clearance", "Regulation of vesicle fusion", "Regulation of vesicle mediated transport", "Regulation of vesicle size", "Regulation of viral entry into host cell", "Regulation of viral genome replication", "Regulation of viral induced cytoplasmic pattern recognition receptor signaling pathway", "Regulation of viral process", "Regulation of viral transcription", "Regulation of vitamin d receptor signaling pathway", "Regulation of vitamin metabolic process", "Regulation of voltage gated calcium channel activity", "Regulation of water loss via skin", "Regulation of wnt signaling pathway", "Regulation of wnt signaling pathway involved in heart development", "Regulation of wound healing", "Regulation of wound healing spreading of epidermal cells", "Regulation of xenophagy", "Regulatory t cell differentiation", "Relaxation of cardiac muscle", "Relaxation of muscle", "Release of cytochrome c from mitochondria", "Release of sequestered calcium ion into cytosol by endoplasmic reticulum", "Renal absorption", "Renal filtration", "Renal sodium excretion", "Renal sodium ion absorption", "Renal sodium ion transport", "Renal system process", "Renal tubular secretion", "Renal tubule development", "Renal vesicle development", "Renal vesicle formation", "Renal water homeostasis", "Replacement ossification", "Replication born double strand break repair via sister chromatid exchange", "Replication fork processing", "Replicative senescence", "Reproduction", "Reproductive behavior", "Reproductive system development", "Rescue of stalled ribosome", "Resolution of meiotic recombination intermediates", "Respiratory burst", "Respiratory burst involved in defense response", "Respiratory burst involved in inflammatory response", "Respiratory chain complex iii assembly", "Respiratory chain complex iv assembly", "Respiratory electron transport chain", "Respiratory gaseous exchange by respiratory system", "Respiratory system development", "Respiratory system process", "Response to abiotic stimulus", "Response to acetylcholine", "Response to acid chemical", "Response to acidic ph", "Response to actinomycin d", "Response to activity", "Response to alcohol", "Response to aldosterone", "Response to alkaloid", "Response to amine", "Response to amino acid starvation", "Response to ammonium ion", "Response to amphetamine", "Response to amyloid beta", "Response to angiotensin", "Response to antibiotic", "Response to arsenic containing substance", "Response to arsenite ion", "Response to atp", "Response to auditory stimulus", "Response to axon injury", "Response to bacterium", "Response to bmp", "Response to cadmium ion", "Response to caffeine", "Response to calcium ion", "Response to camp", "Response to camptothecin", "Response to carbohydrate", "Response to catecholamine", "Response to cell cycle checkpoint signaling", "Response to cgmp", "Response to chemokine", "Response to cisplatin", "Response to cobalt ion", "Response to cocaine", "Response to cold", "Response to copper ion", "Response to corticosteroid", "Response to corticosterone", "Response to cortisol", "Response to cycloheximide", "Response to cytokine", "Response to dexamethasone", "Response to dietary excess", "Response to dopamine", "Response to dsrna", "Response to electrical stimulus", "Response to endogenous stimulus", "Response to endoplasmic reticulum stress", "Response to epidermal growth factor", "Response to epinephrine", "Response to estradiol", "Response to estrogen", "Response to ethanol", "Response to ether", "Response to extracellular stimulus", "Response to fatty acid", "Response to fibroblast growth factor", "Response to fluid shear stress", "Response to folic acid", "Response to follicle stimulating hormone", "Response to food", "Response to fungus", "Response to gamma radiation", "Response to glucagon", "Response to glycoside", "Response to gonadotropin", "Response to granulocyte macrophage colony stimulating factor", "Response to growth factor", "Response to growth hormone", "Response to heat", "Response to heparin", "Response to hepatocyte growth factor", "Response to histamine", "Response to hormone", "Response to human chorionic gonadotropin", "Response to hydrogen peroxide", "Response to hydroperoxide", "Response to hydrostatic pressure", "Response to hydroxyurea", "Response to hyperoxia", "Response to immobilization stress", "Response to increased oxygen levels", "Response to indole 3 methanol", "Response to inorganic substance", "Response to insecticide", "Response to insulin", "Response to interferon alpha", "Response to interferon beta", "Response to interferon gamma", "Response to interleukin 1", "Response to interleukin 12", "Response to interleukin 4", "Response to interleukin 6", "Response to interleukin 7", "Response to ionizing radiation", "Response to iron ii ion", "Response to iron ion", "Response to ischemia", "Response to isoquinoline alkaloid", "Response to ketone", "Response to l ascorbic acid", "Response to l glutamate", "Response to l phenylalanine derivative", "Response to lead ion", "Response to lectin", "Response to leptin", "Response to leucine", "Response to leukemia inhibitory factor", "Response to light intensity", "Response to light stimulus", "Response to lipid", "Response to lipoteichoic acid", "Response to lithium ion", "Response to magnesium ion", "Response to manganese ion", "Response to mechanical stimulus", "Response to mercury ion", "Response to metal ion", "Response to methylmercury", "Response to mineralocorticoid", "Response to misfolded protein", "Response to mitochondrial depolarisation", "Response to molecule of bacterial origin", "Response to monosaccharide", "Response to muramyl dipeptide", "Response to muscle activity", "Response to muscle stretch", "Response to nerve growth factor", "Response to nicotine", "Response to nitric oxide", "Response to nitrogen compound", "Response to nitrosative stress", "Response to nutrient", "Response to oleic acid", "Response to organic cyclic compound", "Response to osmotic stress", "Response to oxidative stress", "Response to oxygen containing compound", "Response to oxygen glucose deprivation", "Response to oxygen levels", "Response to oxygen radical", "Response to pain", "Response to parathyroid hormone", "Response to peptide", "Response to peptide hormone", "Response to peptidoglycan", "Response to ph", "Response to phorbol 13 acetate 12 myristate", "Response to platelet derived growth factor", "Response to potassium ion", "Response to progesterone", "Response to prostaglandin", "Response to prostaglandin e", "Response to purine containing compound", "Response to radiation", "Response to reactive oxygen species", "Response to redox state", "Response to retinoic acid", "Response to salt", "Response to salt stress", "Response to selenium ion", "Response to sodium arsenite", "Response to sorbitol", "Response to starvation", "Response to steroid hormone", "Response to sterol depletion", "Response to temperature stimulus", "Response to testosterone", "Response to thyroglobulin triiodothyronine", "Response to thyroid hormone", "Response to thyroxine", "Response to topologically incorrect protein", "Response to toxic substance", "Response to transforming growth factor beta", "Response to tumor cell", "Response to tumor necrosis factor", "Response to type i interferon", "Response to uv", "Response to uv a", "Response to uv b", "Response to uv c", "Response to virus", "Response to vitamin", "Response to vitamin a", "Response to vitamin d", "Response to vitamin e", "Response to vitamin k", "Response to water", "Response to wounding", "Response to x ray", "Response to xenobiotic stimulus", "Response to zinc ion", "Reticulophagy", "Retina development in camera type eye", "Retina homeostasis", "Retina layer formation", "Retina morphogenesis in camera type eye", "Retina vasculature development in camera type eye", "Retina vasculature morphogenesis in camera type eye", "Retinal cell apoptotic process", "Retinal cone cell differentiation", "Retinal ganglion cell axon guidance", "Retinal metabolic process", "Retinal rod cell development", "Retinal rod cell differentiation", "Retinoic acid metabolic process", "Retinoic acid receptor signaling pathway", "Retinol metabolic process", "Retrograde axonal transport", "Retrograde transport endosome to golgi", "Retrograde transport vesicle recycling within golgi", "Retrograde vesicle mediated transport golgi to endoplasmic reticulum", "Reverse cholesterol transport", "Reversible differentiation", "Rho protein signal transduction", "Rhodopsin mediated signaling pathway", "Rhythmic behavior", "Rhythmic process", "Riboflavin metabolic process", "Ribonucleoprotein complex biogenesis", "Ribonucleoprotein complex disassembly", "Ribonucleoprotein complex localization", "Ribonucleoprotein complex subunit organization", "Ribonucleoside catabolic process", "Ribonucleoside diphosphate biosynthetic process", "Ribonucleoside diphosphate catabolic process", "Ribonucleoside diphosphate metabolic process", "Ribonucleoside metabolic process", "Ribonucleoside monophosphate biosynthetic process", "Ribonucleoside monophosphate catabolic process", "Ribonucleoside monophosphate metabolic process", "Ribonucleoside triphosphate biosynthetic process", "Ribonucleoside triphosphate metabolic process", "Ribonucleotide catabolic process", "Ribose phosphate biosynthetic process", "Ribose phosphate metabolic process", "Ribosomal large subunit assembly", "Ribosomal large subunit biogenesis", "Ribosomal large subunit export from nucleus", "Ribosomal small subunit assembly", "Ribosomal small subunit biogenesis", "Ribosomal small subunit export from nucleus", "Ribosomal subunit export from nucleus", "Ribosome assembly", "Ribosome associated ubiquitin dependent protein catabolic process", "Ribosome biogenesis", "Ribosome disassembly", "Rig i signaling pathway", "Righting reflex", "Rna 3 end processing", "Rna 5 end processing", "Rna capping", "Rna catabolic process", "Rna decapping", "Rna dependent dna biosynthetic process", "Rna destabilization", "Rna export from nucleus", "Rna guanine n7 methylation", "Rna import into mitochondrion", "Rna interference", "Rna localization", "Rna mediated gene silencing by inhibition of translation", "Rna methylation", "Rna modification", "Rna phosphodiester bond hydrolysis", "Rna phosphodiester bond hydrolysis endonucleolytic", "Rna phosphodiester bond hydrolysis exonucleolytic", "Rna polyadenylation", "Rna polymerase i preinitiation complex assembly", "Rna polymerase ii preinitiation complex assembly", "Rna processing", "Rna secondary structure unwinding", "Rna splicing", "Rna splicing via endonucleolytic cleavage and ligation", "Rna splicing via transesterification reactions", "Rna stabilization", "Rna surveillance", "Roof of mouth development", "Roundabout signaling pathway", "Rrna 3 end processing", "Rrna 5 end processing", "Rrna base methylation", "Rrna catabolic process", "Rrna metabolic process", "Rrna methylation", "Rrna modification", "Rrna pseudouridine synthesis", "Rrna transcription", "Rrna transport", "Ruffle assembly", "Ruffle organization", "S adenosylmethionine cycle", "S adenosylmethionine metabolic process", "Salivary gland development", "Sarcomere organization", "Sarcoplasmic reticulum calcium ion transport", "Satellite cell activation involved in skeletal muscle regeneration", "Scarna localization to cajal body", "Scf dependent proteasomal ubiquitin dependent protein catabolic process", "Schwann cell development", "Schwann cell differentiation", "Schwann cell proliferation", "Sebaceous gland development", "Second messenger mediated signaling", "Secondary alcohol metabolic process", "Secondary heart field specification", "Secondary metabolic process", "Secondary metabolite biosynthetic process", "Secondary palate development", "Secretion", "Secretion by tissue", "Secretion of lysosomal enzymes", "Secretory granule localization", "Secretory granule organization", "Segmentation", "Selective autophagy", "Self proteolysis", "Semaphorin plexin signaling pathway", "Semaphorin plexin signaling pathway involved in neuron projection guidance", "Semi lunar valve development", "Semicircular canal development", "Semicircular canal morphogenesis", "Seminiferous tubule development", "Sensory organ development", "Sensory organ morphogenesis", "Sensory perception", "Sensory perception of light stimulus", "Sensory perception of mechanical stimulus", "Sensory perception of pain", "Sensory system development", "Septum primum development", "Sequestering of actin monomers", "Sequestering of calcium ion", "Sequestering of iron ion", "Sequestering of metal ion", "Sequestering of triglyceride", "Sequestering of zinc ion", "Serine family amino acid biosynthetic process", "Serine family amino acid catabolic process", "Serine family amino acid metabolic process", "Serine phosphorylation of stat protein", "Serine transport", "Serotonin metabolic process", "Sertoli cell development", "Sertoli cell differentiation", "Sex determination", "Sex differentiation", "Short chain fatty acid catabolic process", "Short chain fatty acid metabolic process", "Short term memory", "Signal peptide processing", "Signal release", "Signal transduction by p53 class mediator", "Signal transduction in absence of ligand", "Signal transduction in response to dna damage", "Signal transduction involved in regulation of gene expression", "Signaling receptor ligand precursor processing", "Single fertilization", "Single strand break repair", "Single stranded viral rna replication via double stranded dna intermediate", "Sister chromatid cohesion", "Sister chromatid segregation", "Skeletal muscle acetylcholine gated channel clustering", "Skeletal muscle adaptation", "Skeletal muscle cell differentiation", "Skeletal muscle cell proliferation", "Skeletal muscle contraction", "Skeletal muscle fiber differentiation", "Skeletal muscle organ development", "Skeletal muscle satellite cell activation", "Skeletal muscle tissue regeneration", "Skeletal myofibril assembly", "Skeletal system development", "Skeletal system morphogenesis", "Skin development", "Skin epidermis development", "Skin morphogenesis", "Smad protein complex assembly", "Smad protein signal transduction", "Small gtpase mediated signal transduction", "Small molecule biosynthetic process", "Small molecule catabolic process", "Small molecule metabolic process", "Small nucleolar ribonucleoprotein complex assembly", "Small rna loading onto risc", "Smooth muscle adaptation", "Smooth muscle cell apoptotic process", "Smooth muscle cell chemotaxis", "Smooth muscle cell differentiation", "Smooth muscle cell migration", "Smooth muscle cell proliferation", "Smooth muscle contraction", "Smooth muscle tissue development", "Smoothened signaling pathway", "Smoothened signaling pathway involved in dorsal ventral neural tube patterning", "Snare complex assembly", "Sno s rna metabolic process", "Sno s rna processing", "Snorna localization", "Snrna metabolic process", "Snrna modification", "Snrna processing", "Snrna transcription", "Snrna transcription by rna polymerase ii", "Snrna transcription by rna polymerase iii", "Snrna transport", "Sodium independent organic anion transport", "Sodium ion export across plasma membrane", "Sodium ion homeostasis", "Sodium ion import across plasma membrane", "Sodium ion transmembrane transport", "Sodium ion transport", "Somatic diversification of immune receptors", "Somatic diversification of immune receptors via somatic mutation", "Somatic diversification of immunoglobulins", "Somatic diversification of immunoglobulins involved in immune response", "Somatic diversification of t cell receptor genes", "Somatic stem cell population maintenance", "Somite development", "Somite rostral caudal axis specification", "Somitogenesis", "Specification of animal organ identity", "Specification of symmetry", "Sperm capacitation", "Sperm dna condensation", "Sperm egg recognition", "Sperm motility", "Spermatid differentiation", "Spermatid nucleus differentiation", "Spermatogenesis exchange of chromosomal proteins", "Spermidine metabolic process", "Sphingoid metabolic process", "Sphingolipid biosynthetic process", "Sphingolipid mediated signaling pathway", "Sphingolipid metabolic process", "Sphingolipid translocation", "Sphingomyelin biosynthetic process", "Sphingomyelin catabolic process", "Sphingomyelin metabolic process", "Sphingosine biosynthetic process", "Spinal cord development", "Spinal cord motor neuron differentiation", "Spindle assembly", "Spindle assembly involved in female meiosis", "Spindle elongation", "Spindle localization", "Spindle midzone assembly", "Spindle organization", "Spleen development", "Spliceosomal complex assembly", "Spliceosomal conformational changes to generate catalytic conformation", "Spliceosomal snrnp assembly", "Spliceosomal tri snrnp complex assembly", "Spontaneous synaptic transmission", "Sprouting angiogenesis", "Srp dependent cotranslational protein targeting to membrane", "Srp dependent cotranslational protein targeting to membrane signal sequence recognition", "Srp dependent cotranslational protein targeting to membrane translocation", "Startle response", "Stem cell differentiation", "Stem cell division", "Stem cell proliferation", "Steroid biosynthetic process", "Steroid catabolic process", "Steroid esterification", "Steroid hormone biosynthetic process", "Steroid hormone mediated signaling pathway", "Steroid hormone secretion", "Steroid metabolic process", "Sterol biosynthetic process", "Sterol homeostasis", "Sterol import", "Sterol metabolic process", "Sterol transport", "Stress activated protein kinase signaling cascade", "Stress fiber assembly", "Stress granule assembly", "Stress granule disassembly", "Stress induced premature senescence", "Stress response to metal ion", "Striated muscle adaptation", "Striated muscle cell apoptotic process", "Striated muscle cell development", "Striated muscle cell differentiation", "Striated muscle cell proliferation", "Striated muscle contraction", "Striatum development", "Subpallium development", "Substantia nigra development", "Substrate adhesion dependent cell spreading", "Substrate dependent cell migration", "Substrate dependent cell migration cell extension", "Substrate independent telencephalic tangential migration", "Subtelomeric heterochromatin assembly", "Succinate metabolic process", "Succinate transmembrane transport", "Succinyl coa metabolic process", "Suckling behavior", "Sugar mediated signaling pathway", "Sulfate transport", "Sulfur amino acid biosynthetic process", "Sulfur amino acid catabolic process", "Sulfur amino acid metabolic process", "Sulfur compound biosynthetic process", "Sulfur compound catabolic process", "Sulfur compound metabolic process", "Sulfur compound transport", "Superoxide anion generation", "Superoxide metabolic process", "Suppression of viral release by host", "Supramolecular fiber organization", "Sympathetic ganglion development", "Sympathetic nervous system development", "Synapse assembly", "Synapse maturation", "Synapse organization", "Synapse pruning", "Synaptic membrane adhesion", "Synaptic signaling", "Synaptic transmission dopaminergic", "Synaptic transmission gabaergic", "Synaptic transmission glutamatergic", "Synaptic vesicle budding", "Synaptic vesicle clustering", "Synaptic vesicle cytoskeletal transport", "Synaptic vesicle docking", "Synaptic vesicle endosomal processing", "Synaptic vesicle exocytosis", "Synaptic vesicle localization", "Synaptic vesicle maturation", "Synaptic vesicle membrane organization", "Synaptic vesicle priming", "Synaptic vesicle recycling", "Synaptic vesicle recycling via endosome", "Synaptic vesicle transport", "Synaptic vesicle uncoating", "Synaptonemal complex organization", "Syncytium formation", "T cell activation", "T cell activation involved in immune response", "T cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell", "T cell apoptotic process", "T cell chemotaxis", "T cell cytokine production", "T cell differentiation", "T cell differentiation in thymus", "T cell differentiation involved in immune response", "T cell extravasation", "T cell homeostasis", "T cell lineage commitment", "T cell mediated cytotoxicity", "T cell mediated immune response to tumor cell", "T cell mediated immunity", "T cell migration", "T cell proliferation", "T cell proliferation involved in immune response", "T cell receptor signaling pathway", "T cell selection", "T cell tolerance induction", "T helper 1 cell differentiation", "T helper 1 type immune response", "T helper 17 cell differentiation", "T helper 17 cell lineage commitment", "T helper 17 type immune response", "T helper 2 cell differentiation", "T helper cell lineage commitment", "T tubule organization", "Tail anchored membrane protein insertion into er membrane", "Tangential migration from the subventricular zone to the olfactory bulb", "Taxis", "Telencephalon development", "Telencephalon glial cell migration", "Telencephalon regionalization", "Telomerase holoenzyme complex assembly", "Telomerase rna localization", "Telomere capping", "Telomere maintenance", "Telomere maintenance in response to dna damage", "Telomere maintenance via recombination", "Telomere maintenance via semi conservative replication", "Telomere maintenance via telomere lengthening", "Telomere organization", "Temperature homeostasis", "Terminal button organization", "Termination of rna polymerase ii transcription", "Terpenoid biosynthetic process", "Terpenoid metabolic process", "Tertiary alcohol metabolic process", "Tetrahydrobiopterin metabolic process", "Tetrahydrofolate biosynthetic process", "Tetrahydrofolate interconversion", "Tetrahydrofolate metabolic process", "Tetrapyrrole biosynthetic process", "Tetrapyrrole catabolic process", "Tetrapyrrole metabolic process", "Thalamus development", "Thiamine containing compound metabolic process", "Thiamine transport", "Thioester biosynthetic process", "Thioester metabolic process", "Thorax and anterior abdomen determination", "Threonine catabolic process", "Threonine metabolic process", "Thrombin activated receptor signaling pathway", "Thrombopoietin mediated signaling pathway", "Thymocyte apoptotic process", "Thymus development", "Thyroid gland development", "Thyroid hormone generation", "Thyroid hormone mediated signaling pathway", "Thyroid hormone metabolic process", "Thyroid hormone transport", "Tight junction organization", "Tissue development", "Tissue migration", "Tissue morphogenesis", "Tissue regeneration", "Tissue remodeling", "Tolerance induction", "Toll like receptor 3 signaling pathway", "Toll like receptor 4 signaling pathway", "Toll like receptor 7 signaling pathway", "Toll like receptor 8 signaling pathway", "Toll like receptor 9 signaling pathway", "Toll like receptor signaling pathway", "Tongue development", "Tongue morphogenesis", "Tooth mineralization", "Tor signaling", "Torc1 signaling", "Torc2 signaling", "Toxin metabolic process", "Toxin transport", "Trabecula formation", "Trabecula morphogenesis", "Trachea development", "Trachea formation", "Trachea morphogenesis", "Trail activated apoptotic signaling pathway", "Transcription by rna polymerase i", "Transcription by rna polymerase iii", "Transcription coupled nucleotide excision repair", "Transcription dependent tethering of rna polymerase ii gene dna at nuclear periphery", "Transcription elongation from rna polymerase i promoter", "Transcription elongation from rna polymerase ii promoter", "Transcription factor catabolic process", "Transcription initiation from rna polymerase i promoter", "Transcription initiation from rna polymerase ii promoter", "Transcription initiation from rna polymerase iii promoter", "Transcription preinitiation complex assembly", "Transcytosis", "Transepithelial chloride transport", "Transepithelial transport", "Transferrin transport", "Transforming growth factor beta activation", "Transforming growth factor beta production", "Transforming growth factor beta receptor signaling pathway", "Transforming growth factor beta1 production", "Transition between fast and slow fiber", "Transition metal ion homeostasis", "Transition metal ion transport", "Translational elongation", "Translational initiation", "Translational readthrough", "Translational termination", "Translesion synthesis", "Translocation of molecules into host", "Transmembrane receptor protein serine threonine kinase signaling pathway", "Transmembrane receptor protein tyrosine kinase signaling pathway", "Transmembrane receptor protein tyrosine phosphatase signaling pathway", "Transmembrane transport", "Transmission of nerve impulse", "Transport along microtubule", "Transport of virus", "Transposition", "Transposition rna mediated", "Tricarboxylic acid cycle", "Tricarboxylic acid metabolic process", "Triglyceride biosynthetic process", "Triglyceride metabolic process", "Tripartite regional subdivision", "Tripeptide transmembrane transport", "Tripeptide transport", "Trivalent inorganic anion homeostasis", "Trna 3 end processing", "Trna 5 end processing", "Trna 5 leader removal", "Trna aminoacylation for mitochondrial protein translation", "Trna catabolic process", "Trna metabolic process", "Trna methylation", "Trna modification", "Trna processing", "Trna pseudouridine synthesis", "Trna thio modification", "Trna threonylcarbamoyladenosine metabolic process", "Trna transcription", "Trna transport", "Trna wobble base modification", "Trna wobble uridine modification", "Trophectodermal cell differentiation", "Trophoblast cell migration", "Trophoblast giant cell differentiation", "Tryptophan transport", "Tube development", "Tube formation", "Tube morphogenesis", "Tubulin complex assembly", "Tubulin deacetylation", "Tumor necrosis factor mediated signaling pathway", "Tumor necrosis factor superfamily cytokine production", "Type 2 immune response", "Type b pancreatic cell apoptotic process", "Type b pancreatic cell development", "Type i interferon production", "Type i pneumocyte differentiation", "Tyrosine catabolic process", "Tyrosine metabolic process", "Tyrosine phosphorylation of stat protein", "U4 snrna 3 end processing", "Ubiquinone metabolic process", "Ubiquitin dependent endocytosis", "Ubiquitin dependent erad pathway", "Ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin dependent smad protein catabolic process", "Ubiquitin independent protein catabolic process via the multivesicular body sorting pathway", "Ubiquitin recycling", "Udp glucose metabolic process", "Udp n acetylglucosamine biosynthetic process", "Udp n acetylglucosamine metabolic process", "Ump biosynthetic process", "Unsaturated fatty acid biosynthetic process", "Unsaturated fatty acid metabolic process", "Urate metabolic process", "Urea cycle", "Urea metabolic process", "Urogenital system development", "Uronic acid metabolic process", "Uterus development", "Uterus morphogenesis", "Utp biosynthetic process", "Utp metabolic process", "Uv damage excision repair", "Uv protection", "V d j recombination", "Vacuolar acidification", "Vacuolar localization", "Vacuolar proton transporting v type atpase complex assembly", "Vacuolar transport", "Vacuole organization", "Valine metabolic process", "Vascular associated smooth muscle cell apoptotic process", "Vascular associated smooth muscle cell differentiation", "Vascular associated smooth muscle cell migration", "Vascular associated smooth muscle cell proliferation", "Vascular associated smooth muscle contraction", "Vascular endothelial cell proliferation", "Vascular endothelial growth factor production", "Vascular endothelial growth factor receptor 2 signaling pathway", "Vascular endothelial growth factor receptor signaling pathway", "Vascular endothelial growth factor signaling pathway", "Vascular process in circulatory system", "Vascular transport", "Vascular wound healing", "Vasculature development", "Vasculogenesis", "Vasoconstriction", "Vasodilation", "Ventral spinal cord development", "Ventricular cardiac muscle cell action potential", "Ventricular cardiac muscle cell development", "Ventricular cardiac muscle cell differentiation", "Ventricular cardiac muscle cell membrane repolarization", "Ventricular cardiac muscle tissue development", "Ventricular cardiac muscle tissue morphogenesis", "Ventricular compact myocardium morphogenesis", "Ventricular septum development", "Ventricular septum morphogenesis", "Ventricular system development", "Ventricular trabecula myocardium morphogenesis", "Very long chain fatty acid catabolic process", "Very long chain fatty acid metabolic process", "Very low density lipoprotein particle assembly", "Very low density lipoprotein particle clearance", "Vesicle budding from membrane", "Vesicle cargo loading", "Vesicle cytoskeletal trafficking", "Vesicle docking", "Vesicle docking involved in exocytosis", "Vesicle fusion to plasma membrane", "Vesicle fusion with golgi apparatus", "Vesicle localization", "Vesicle mediated transport", "Vesicle mediated transport between endosomal compartments", "Vesicle mediated transport in synapse", "Vesicle mediated transport to the plasma membrane", "Vesicle organization", "Vesicle targeting", "Vesicle targeting rough er to cis golgi", "Vesicle targeting to from or within golgi", "Vesicle tethering", "Vesicle tethering to golgi", "Vesicle transport along microtubule", "Vesicle uncoating", "Viral budding", "Viral gene expression", "Viral genome replication", "Viral life cycle", "Viral process", "Viral protein processing", "Viral release from host cell", "Viral rna genome replication", "Viral transcription", "Viral translation", "Viral translational termination reinitiation", "Virion assembly", "Virion attachment to host cell", "Visual behavior", "Vitamin a metabolic process", "Vitamin b6 metabolic process", "Vitamin biosynthetic process", "Vitamin catabolic process", "Vitamin d metabolic process", "Vitamin d receptor signaling pathway", "Vitamin k metabolic process", "Vitamin metabolic process", "Vitamin transmembrane transport", "Vitamin transport", "Vocalization behavior", "Voluntary musculoskeletal movement", "Walking behavior", "Water homeostasis", "Water soluble vitamin biosynthetic process", "Water soluble vitamin metabolic process", "Water transport", "White fat cell differentiation", "Wnt protein secretion", "Wnt signaling pathway involved in heart development", "Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation", "Wound healing", "Wound healing involved in inflammatory response", "Wound healing spreading of epidermal cells", "Xenobiotic catabolic process", "Xenobiotic export", "Xenobiotic metabolic process", "Xenobiotic transport", "Xenobiotic transport across blood brain barrier", "Xenophagy", "Xmp metabolic process", "Zinc ion homeostasis", "Zinc ion transport", "Zygotic determination of anterior posterior axis embryo", "Zymogen activation", "Zymogen inhibition"], "available_proteins": ["AAAS", "AACS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABCF1", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABRAXAS2", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AGTRAP", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK6", "AKAP1", "AKAP12", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG5", "ALKBH5", "ALYREF", "AMOT", "AMPD2", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APOBEC3C", "APOL2", "APOOL", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6", "ARL6IP1", "ARL6IP5", "ARL8A", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ASAH1", "ASCC1", "ASCC3", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATG9A", "ATIC", "ATP11C", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "B3GALT6", "B4GAT1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS2", "BCCIP", "BCL2L13", "BCLAF1", "BCOR", "BCS1L", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRD1", "BRD2", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf43", "C19orf70", "C1QBP", "C2orf49", "CAB39", "CACNA2D1", "CACYBP", "CAD", "CALD1", "CALR", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASK", "CAST", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC22", "CCDC47", "CCDC6", "CCDC8", "CCDC93", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD47", "CDC123", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA2", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CENPF", "CENPI", "CEP44", "CEP55", "CEPT1", "CERS2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD7", "CHEK2", "CHERP", "CHID1", "CHKA", "CHMP2A", "CHMP2B", "CHMP4B", "CHMP5", "CHMP6", "CHMP7", "CHORDC1", "CHTF18", "CHTOP", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COG2", "COG4", "COG7", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7B", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWC22", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBR1", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTPP1", "DCUN1D1", "DCXR", "DDA1", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX52", "DDX54", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS13", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX34", "DHX35", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DIP2B", "DIS3", "DKC1", "DLAT", "DLD", "DLGAP5", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC17", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOCK7", "DOHH", "DPH5", "DPM1", "DPP3", "DPYSL2", "DR1", "DRG1", "DRG2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "DYNLL2", "DYNLT1", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC4", "EDF1", "EDRF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMOD2", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERCC6L", "ERG28", "ERGIC1", "ERGIC2", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESS2", "ESYT1", "ETF1", "ETFA", "ETFB", "ETFDH", "EXO1", "EXOC5", "EXOC6", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FAF1", "FAF2", "FAH", "FAM162A", "FAM208A", "FAM213A", "FAM49B", "FAM8A1", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD5", "FBL", "FBXO7", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP10", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNDC3A", "FNTA", "FNTB", "FOXRED1", "FRG1", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "FYTTD1", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDAP2", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GGH", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLB1L2", "GLDC", "GLG1", "GLMN", "GLO1", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGB1", "GOLM1", "GORASP2", "GOT1", "GOT2", "GPAA1", "GPATCH4", "GPD1L", "GPD2", "GPHN", "GPI", "GPR107", "GPR108", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSDME", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GTF2F1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS5", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEBP1", "HEBP2", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HEXIM1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGA2", "HMGB1", "HMGB2", "HMGB3", "HMGCR", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPF1", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPB11", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICE1", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFIT5", "IFNGR1", "IFT27", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INCENP", "INTS1", "INTS13", "INTS14", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQSEC1", "IRF2BPL", "IRS4", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITM2B", "ITPA", "ITPK1", "IVD", "IWS1", "JAGN1", "JMJD6", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0368", "KIF11", "KIF14", "KIF18A", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "LAMP1", "LAMTOR1", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIG3", "LIMA1", "LIN28B", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRSAM1", "LRWD1", "LSM14A", "LSM2", "LSM4", "LSM6", "LSM7", "LSM8", "LSS", "LTA4H", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAK16", "MANBA", "MANF", "MAP1B", "MAP2K1", "MAP2K4", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKS", "MARCKSL1", "MARS", "MAT2A", "MAT2B", "MATR3", "MAU2", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MDC1", "MDH1", "MDH2", "MDN1", "ME2", "MECP2", "MED24", "MED4", "METTL13", "METTL16", "MFAP1", "MFF", "MFN1", "MFN2", "MFSD10", "MFSD14B", "MFSD3", "MFSD5", "MFSD8", "MGAT1", "MGEA5", "MGME1", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MIPEP", "MKI67", "MKRN2", "MLEC", "MMADHC", "MMS19", "MOGS", "MORC2", "MORF4L1", "MORF4L2", "MOV10", "MPDU1", "MPG", "MPHOSPH10", "MPHOSPH8", "MPI", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL20", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL41", "MRPL43", "MRPL44", "MRPL47", "MRPL51", "MRPL9", "MRPS11", "MRPS15", "MRPS17", "MRPS2", "MRPS27", "MRPS28", "MRPS30", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MUT", "MYADM", "MYBBP1A", "MYCBP", "MYCBP2", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH9", "MYL6", "MYL6B", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NAE1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NCAPD2", "NCAPD3", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "ND1", "NDC1", "NDRG3", "NDUFA10", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV2", "NECAP2", "NEDD4L", "NEFM", "NEK9", "NELFB", "NELFCD", "NELFE", "NENF", "NF1", "NFATC2IP", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIPSNAP2", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NOVA2", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NUB1", "NUCB1", "NUCB2", "NUDC", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "OXCT1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PAPSS2", "PARK7", "PARN", "PARP1", "PAWR", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDS5A", "PDS5B", "PDXDC1", "PDZD11", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PIBF1", "PICALM", "PIGK", "PIGS", "PIGT", "PIK3C2A", "PIK3R4", "PIN4", "PIR", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLRG1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNN", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2D", "POLR2G", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "PON2", "POP1", "POP7", "POR", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL4", "PPM1F", "PPM1G", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA1", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38A", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2C", "PRSS3", "PRTFDC1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSPC1", "PTBP1", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS7", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "PYM1", "QARS", "QKI", "QPRT", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB23", "RAB2A", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM28", "RBM3", "RBM39", "RBM4", "RBM42", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "REEP5", "REPS1", "RER1", "RETREG3", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIDA", "RIF1", "RIPK1", "RMDN1", "RNASEH2A", "RNASEH2B", "RNASET2", "RNF14", "RNF2", "RNF20", "RNF219", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK1", "RPA1", "RPA2", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RSU1", "RTCB", "RTFDC1", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SCYL2", "SDAD1", "SDE2", "SDHA", "SDHB", "SEC11A", "SEC13", "SEC14L2", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SELENBP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHMT2", "SHTN1", "SIGMAR1", "SIL1", "SIN3A", "SIRT1", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC2A1", "SLC30A7", "SLC35A4", "SLC35B2", "SLC35F2", "SLC38A1", "SLC3A2", "SLC7A1", "SLC7A5", "SLC9A3R1", "SLC9A6", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SORT1", "SPAG5", "SPAG9", "SPART", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPECC1", "SPECC1L", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRFBP1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3", "STARD3NL", "STAT1", "STAT3", "STAU1", "STIP1", "STMN1", "STOML2", "STRAP", "STRBP", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SV2A", "SWAP70", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TAB1", "TACC3", "TAF15", "TAF2", "TAF5", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TAOK1", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D15", "TBC1D4", "TBC1D8B", "TBC1D9B", "TBCA", "TBCD", "TBCE", "TBK1", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCF25", "TCOF1", "TCP1", "TECR", "TELO2", "TERF2IP", "TES", "TFAM", "TFB1M", "TFG", "TFIP11", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "TIA1", "TIAL1", "TIGAR", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TJP1", "TK1", "TKT", "TLN1", "TM9SF2", "TM9SF3", "TM9SF4", "TMCO1", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM115", "TMEM126A", "TMEM14C", "TMEM167A", "TMEM199", "TMEM201", "TMEM214", "TMEM230", "TMEM259", "TMEM33", "TMEM43", "TMEM65", "TMEM97", "TMOD3", "TMTC3", "TMX1", "TMX2", "TNPO1", "TNPO3", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1AIP2", "TP53", "TP53BP1", "TP53BP2", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPRKB", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC4", "TRAPPC5", "TRAPPC8", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMT11", "TRMT112", "TRMT1L", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSNAX", "TSPAN6", "TSPO", "TSPYL1", "TSR1", "TSR3", "TST", "TSTA3", "TTC1", "TTC19", "TTC21B", "TTC26", "TTC37", "TTC4", "TTLL12", "TTLL4", "TTYH3", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL4A", "TXNRD1", "TXNRD2", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBL5", "UBLCP1", "UBQLN4", "UBR1", "UBR4", "UBR5", "UBTF", "UBXN4", "UCHL5", "UFD1", "UFL1", "UFM1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "URB2", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP33", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VMP1", "VPS16", "VPS25", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4A", "VPS4B", "VPS50", "VRK1", "VRK3", "VTA1", "WAPL", "WARS", "WARS2", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR70", "WDR75", "WDR77", "WDR82", "WFS1", "WIZ", "WNK1", "WTAP", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS2", "YIF1A", "YIPF5", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBTB10", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCRB1", "ZFYVE16", "ZMPSTE24", "ZMYM4", "ZMYND8", "ZNF207", "ZNF318", "ZNF326", "ZNF512B", "ZNF638", "ZPR1", "ZRANB2", "ZW10", "ZYX"], "leading_proteins": ["AAMP", "AARS", "AARS2", "AASDHPPT", "AATF", "ABCB1", "ABHD10", "ABRAXAS2", "ACAD11", "ACADVL", "ACAT2", "ACOT8", "ACOX1", "ACOX3", "ACP2", "ACP6", "ACTN1", "ACTN4", "ACTR2", "ADAR", "ADD1", "ADK", "ADNP", "ADRM1", "AGK", "AGL", "AGPAT1", "AGPS", "AGTRAP", "AHCYL1", "AIFM1", "AIMP2", "AKAP8", "AKAP8L", "AKT2", "ALDH3A2", "AMOT", "ANAPC1", "ANAPC2", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANKRD17", "ANP32A", "ANP32B", "ANXA1", "ANXA11", "ANXA7", "AP3M1", "AP3S1", "API5", "APLP2", "APOBEC3C", "APOL2", "APPL1", "ARF4", "ARFGAP2", "ARG2", "ARHGEF7", "ARL1", "ARL2", "ARMT1", "ASCC3", "ASPH", "ATAD1", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5F1", "ATP5L", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1C1", "ATP6V1E1", "ATPAF1", "ATPIF1", "AUP1", "B4GAT1", "BABAM2", "BAG6", "BAIAP2", "BASP1", "BCCIP", "BICD2", "BOLA2*", "BRD1", "BSG", "BUB1B", "C1QBP", "C2orf49", "CACNA2D1", "CAPRIN1", "CARM1", "CASK", "CCDC134", "CCDC47", "CCNB2", "CDC16", "CDC23", "CDC37", "CDC42", "CDK11B", "CDK12", "CDK2", "CDK4", "CDK5RAP3", "CDKN2AIP", "CENPF", "CENPI", "CEP44", "CEP55", "CERS2", "CHD1", "CHD7", "CHEK2", "CHKA", "CHMP2A", "CHMP4B", "CIRBP", "CLCN3", "CLIC1", "CLIC4", "CLN5", "CLNS1A", "CLPP", "CLPTM1L", "CLUH", "CNN3", "CNNM3", "CNNM4", "CNOT7", "CNP", "COA3", "COLEC12", "COMT", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7B", "COPS8", "CORO1C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF7", "CPT2", "CPVL", "CRKL", "CRTAP", "CSK", "CTBP1", "CTCF", "CTNNB1", "CTNNBL1", "CTPS1", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CYB5B", "CYB5D2", "CYFIP1", "CYP51A1", "DBN1", "DCPS", "DCTN1", "DCTN2", "DCTPP1", "DCUN1D1", "DDB1", "DDRGK1", "DDX10", "DDX17", "DDX21", "DDX3X", "DDX5", "DDX56", "DEK", "DFFA", "DHCR24", "DHFR", "DHX33", "DHX9", "DIABLO", "DIP2B", "DIS3", "DNAJA2", "DNAJB11", "DNAJC10", "DNAJC2", "DNM1L", "DNM2", "DNMT1", "DOHH", "DPH5", "DPM1", "DSG2", "DYNLL1", "ECE1", "ECI1", "EDF1", "EEF1A2", "EHD4", "EIF4A3", "EIF4B", "EIF4G1", "EIF5", "ELAVL1", "ELOC", "ELP2", "ELP3", "EMD", "EPB41", "EPB41L2", "EPHX1", "EPPK1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERG28", "ERGIC2", "ERGIC3", "ERLIN1", "ERO1A", "EXO1", "EXOC5", "EXOSC6", "EXOSC8", "F11R", "FAM162A", "FAM208A", "FAM49B", "FAM8A1", "FARSA", "FASN", "FBXO7", "FCGRT", "FDFT1", "FGFR1OP", "FKBP10", "FKBP1A", "FLNA", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNTB", "FOXRED1", "FTO", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G6PD", "GAA", "GAK", "GALNT1", "GALNT7", "GBA", "GCDH", "GCLM", "GDAP1", "GDAP2", "GGCX", "GGH", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLRX3", "GLRX5", "GLUD1", "GM2A", "GNA13", "GNL3L", "GNPDA1", "GOLGB1", "GOLM1", "GPAA1", "GPR107", "GPR108", "GRB2", "GSDME", "GSS", "GSTM2", "GSTM3", "GSTO1", "GTF2F1", "GUSB", "GYS1", "HACD3", "HADH", "HADHA", "HDAC1", "HDAC2", "HELLS", "HEXA", "HEXIM1", "HGS", "HK2", "HLA-A", "HLA-B", "HLA-C", "HM13", "HMCES", "HMGA2", "HMOX1", "HMOX2", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPU", "HPF1", "HS2ST1", "HSP90AA1", "HSP90AB1", "HSPB1", "HTT", "ICE1", "ICMT", "IDH1", "IDH2", "IFNGR1", "IFT27", "IGBP1", "IGF1R", "IGF2BP2", "IGF2BP3", "IGF2R", "ILF3", "IPO5", "IQGAP1", "ITM2B", "IWS1", "JMJD6", "KDM1B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIF11", "KIF18A", "KIF2C", "KIF5B", "KMT2A", "KPNA1", "KPNA3", "KPNA4", "KPNA6", "LAMP1", "LANCL1", "LARP1", "LARP4", "LARP4B", "LARP7", "LASP1", "LBR", "LGALS3", "LGALS3BP", "LMAN1", "LMAN2", "LMNA", "LNPEP", "LPCAT1", "LRP1", "LRPAP1", "LRWD1", "LSM14A", "LSS", "LTA4H", "MANBA", "MANF", "MAP2K1", "MAP2K4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARS", "MATR3", "MAU2", "MBD3", "MBOAT7", "MCL1", "MCM2", "METTL13", "MFSD14B", "MFSD3", "MFSD8", "MGEA5", "MIA2", "MID1", "MIF", "MINDY3", "MKRN2", "MMADHC", "MORC2", "MOV10", "MPG", "MPP2", "MPV17L2", "MRE11", "MRPL41", "MSH6", "MSMO1", "MTAP", "MTBP", "MTCH2", "MTMR6", "MTOR", "MTPAP", "MTX1", "MYADM", "MYBBP1A", "MYCBP", "MYL6", "MYL6B", "NAA40", "NAE1", "NAGLU", "NAMPT", "NAP1L1", "NASP", "NCAPH", "NCDN", "NCOA5", "NCSTN", "NDC1", "NDUFA13", "NDUFAF2", "NDUFB3", "NDUFB9", "NDUFS2", "NDUFS3", "NELFB", "NELFCD", "NENF", "NF1", "NLE1", "NLN", "NME1", "NMT1", "NPC1", "NPC2", "NPEPPS", "NSD2", "NSFL1C", "NSUN2", "NT5C3B", "NT5DC1", "NTMT1", "NUB1", "NUCB2", "NUMA1", "NUP107", "NUP155", "NUP160", "NUP37", "NUP62", "NUP85", "NUP88", "OCIAD1", "OSBPL8", "OTUB1", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HB", "PABPC1", "PABPC4", "PAF1", "PAIP1", "PAIP2", "PALLD", "PAPOLA", "PAWR", "PBK", "PCK2", "PCM1", "PCNA", "PCYOX1", "PDCD4", "PDCD5", "PDCD6IP", "PDCL3", "PDE6D", "PDLIM5", "PEBP1", "PECR", "PEX19", "PFDN4", "PFDN6", "PFN1", "PFN2", "PGRMC1", "PGRMC2", "PHF6", "PI4KA", "PIBF1", "PIGS", "PIR", "PITRM1", "PLA2G15", "PLAA", "PLBD2", "PLD3", "PLD6", "PLEC", "PLK1", "PMPCA", "POLDIP2", "POLE", "POLR2D", "PON2", "POR", "PPIF", "PPIL4", "PPP1CA", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PRCP", "PRIM1", "PRIM2", "PRKAA1", "PRKACA", "PRKAR1A", "PRKDC", 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8 14 3.0112103869242937 0.0026020849349044 5.325242718446602 14.563106796116504 1.2215341624098188 0.3078540255827756 2.4387733048296822 0.5516067072365743 1.1166106206832802 0.3218631020970666 0.0001967001664997 0.0030581061915538 0.0005309775927247 6.917341646628312e-08 2.392522175580337e-08 +Vacuolar membrane 29 108 2.9459406532186247 0.0032197416944441 31.91504854368932 121.20631067961163 0.8693310080509177 0.3422944242486927 10.598363436017626 13.850227259030053 1.9844114292962869 0.3837860427998523 0.0020750665733818 0.0058152150735298 1.8978941121453413e-05 0.0005146048358705 0.0004555107748037 +Azurophil granule 21 64 2.757745291474736 0.0058201528536365 20.46359223300971 67.00485436893204 0.4795255752980384 0.3097891700346699 6.177875864944045 5.290582926033595 2.1760997104513735 0.3628132485163926 0.186736447660423 0.433640456963297 0.0987427785556486 2.033133062369488e-05 5.113996218804716e-09 +Nls dependent protein nuclear import complex 3 7 2.5525457328791203 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0.0147357969549857 3.1723300970873787 11.17233009708738 1.083137374920517 0.3054753623634815 1.8106779848505148 1.1913569842207026 0.9186852151104662 0.2868810804648729 0.0059119908073892 0.0802348466038066 0.0113213926532688 3.830880641039723e-05 0.0010053263520343 +Tim23 mitochondrial import inner membrane translocase complex 1 6 2.38660626092016 0.0170046923861548 2.2694174757281553 6.342233009708738 1.5180442383336388 0.125307709046494 1.369833329272529 0.8106469094037756 1.2674744491900518 0.2021471972412396 0.002455307972466 0.0012601973854463 0.0047533286028597 0.0276231155809849 0.0968157430558884 +Nucleocytoplasmic transport complex 3 9 2.344433823740929 0.0190559918511117 3.798543689320388 8.162621359223301 -0.3077911450287571 0.588309355188164 2.2909060012020728 0.6792778306365291 0.7276517436460556 0.2835857013964484 3.5930470170495774e-05 1.2998708524751297e-05 9.839858993160587e-05 6.194004931981708e-05 0.0009118158302113 +Collagen containing extracellular matrix 6 25 2.318201557702228 0.0204383694234171 7.388349514563107 28.936893203883496 0.1094979606259816 0.5901779878192949 3.847790968094583 3.6231320005554526 0.9701213079318116 0.3238613597958452 0.6213465125323765 0.4999158516222215 0.3906542776432947 0.2494349853620711 0.369976220421185 +Pore complex 1 9 2.1221657963202465 0.0338238177073464 3.2111650485436893 8.830097087378642 1.029129610796519 0.2182996080526768 1.893158762220583 0.772882004264421 1.343874754683687 0.2717215815078918 0.0059119908073892 0.0030581061915538 0.0113213926532688 0.0621585272883563 0.1985866733922443 +Intrinsic component of organelle membrane 20 109 2.0903792420067577 0.0365837460648594 52.51699029126213 129.34223300970874 2.0732064315361294 0.2796588394070637 24.692225942786415 15.820346456508432 2.8130846896968285 0.39829365000917 0.0554285240792724 0.0594082876485634 0.0256829472731461 0.0062827008597547 0.0208541386881489 +Anaphase promoting complex 8 10 2.052903323674661 0.0400819546201736 3.650485436893204 9.951456310679612 0.4398323060905144 0.5535167888164183 2.3053704201407115 1.779760214986425 0.8260937825244029 0.3229882386789853 1.0 1.0 1.0 1.0 0.2531867173469597 +Copii vesicle coat 1 10 2.0106141307098064 0.0443662303179326 3.2014563106796117 10.5752427184466 -0.1834989750122314 0.5732167498091361 1.978205967545592 1.102366690229949 0.8158239847898484 0.2843735158193445 1.0 1.0 1.0 0.0435926191526008 0.1457988469723397 +Intrinsic component of mitochondrial inner membrane 3 27 1.9751219330393783 0.0482543123707879 13.946601941747574 31.446601941747577 1.7062420859184484 0.2149692261988765 6.992163651608136 3.3601842163433866 1.8185871159494191 0.3070405082296492 0.0460722283357764 0.0248568883498602 0.0832345551471358 0.03203241935523 0.0330537609250841 +Proteasome complex 9 46 1.9699760634561676 0.0488411139344366 14.026699029126211 46.786407766990294 0.4420598252615278 0.5373615775614314 7.719082757566109 2.020047511874643 1.333666971110317 0.369590668247101 0.0059850441464068 0.0286799036387023 0.0149914480702132 0.0002941476334404 4.524440963497809e-05 +Schaffer collateral ca1 synapse 3 12 1.9628403721126035 0.0496647250816704 3.2888349514563107 15.04611650485437 0.526101921661134 0.5717891227457014 2.2676645532699578 1.9195745549114556 0.7194455680396641 0.3088986439388705 0.2464885566659048 0.1828652209005429 0.327507803675052 0.260178364686727 0.1361773244383703 diff --git a/msigdb_gocc/metrics.json b/msigdb_gocc/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..041d5bce76ecc29f96e4943bb77dbbc43dcdb32e --- /dev/null +++ b/msigdb_gocc/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2812, + "annotations_size": 895, + "title": "Average number of proteins per term", + "value": 26.06927374301676 +} \ No newline at end of file diff --git a/msigdb_gocc/paths.json b/msigdb_gocc/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..141e24722882d0405ab498e12330f5945f03650d --- /dev/null +++ b/msigdb_gocc/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gocc/fragment/C428/C428_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gocc/result.tsv b/msigdb_gocc/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..2ec94993b6ee05774ddc7de2c7cefd1f2a4432f2 --- /dev/null +++ b/msigdb_gocc/result.tsv @@ -0,0 +1,253 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Vacuolar lumen 0.6846799852885636 4.411511303236644 1.0265159445577154e-05 0.0091452899732639 0.0068170091724235 60 P68371,Q9BTY2,P08236,P06865,P07858,P16278,O00584,P06280,Q9UMR5,Q8NHP8,P10619,P50897,Q8IV08,Q92820,P11117,P54802,Q14108,P04062,O14773,P07602,P07437,Q9H7Z7,P17900 23 +Lysosomal lumen 0.7890755342826582 4.163394075048011 3.135515195618055e-05 0.0276731843751239 0.0068170091724235 33 P16278,Q8NHP8,P10619,P50897,O00584,O14773,P07602,Q8IV08,P06280,P11117,P08236,P54802,P06865,Q14108,P04062,P17900,Q9UMR5,P07858 18 +Endoplasmic reticulum 0.389060349690047 4.118807268315148 3.808385012527005e-05 0.0335113220846613 0.0068170091724235 407 P30536,P07099,Q9Y282,Q15392,Q5BJF2,O75503,Q9UQB8,Q96G23,P30519,Q9UMX5,O15173,O75844,P80303,Q8N511,O95881,P10619,Q16850,O60725,Q8IV08,P09601,O15118,Q14108,P04062,Q32P28,Q9HD20,Q86XL3,Q06481,Q15437,Q06136,Q92791,P43307,Q14257,P55735,Q9H2J4,Q9BTY2,P48449,O95197,Q15800,Q9BQE5,P13674,P04439,O00584,P01889,O15260,Q8NFQ8,O43852,O60506,O15270,Q9P2W9,O43390,Q9Y679,Q14739,P42858,Q96PC5,Q15904,Q7L0J3,Q01105,Q9NQC3,O75718,O43493,Q6P179,O00264,P39687,Q8NF37,Q9BZF1,O95772,P62942,Q15629,Q8NBJ4,P48723,P10321,Q8TCT9,Q9H6E4,O43865,Q9UHB9,Q99523,Q9H223,Q9Y217,Q02750,P35573,Q9UBS4,Q99943,Q8TB61,Q96AY3,Q96N66,P61916,P50402,P04844,Q9UKR5,Q9NZ08,P51648,Q12907,P37268,Q6RW13,Q969M3,Q92542,Q12955 97 +Vacuole 0.5059483319130345 3.3731630689561354 0.0007430992962469 0.4858915793165577 0.0665073870141012 192 Q99829,P55735,P68371,P04066,Q9BTY2,Q5BJF2,P42785,Q9NXN4,Q8NHS3,O75503,P08236,P36543,P06865,Q9UIQ6,P07858,P16278,P61916,Q01650,Q8WTV0,O00584,Q8NF37,Q9Y487,Q93050,P06280,O15260,P10253,O95772,O95721,Q9UHG3,Q8N511,Q9UMR5,Q8NHP8,P10619,P50897,Q8IV08,P50995,Q92820,Q99523,O15118,P54802,Q14108,Q8NCC3,P42892,P04062,P11117,Q8IW92,Q9Y679,O14773,P07602,P42858,Q15165,O14964,P19474,P07437,Q07954,Q9Y2T2,Q9H7Z7,P17900 58 +Proteasome core complex 0.8180527225900656 3.0112103869242937 0.0026020849349044 0.9028890594231886 0.1600927120293072 14 P25788,P28074,P20618,Q99436,P28072,P28070,P49721,P60900 8 +Vacuolar membrane 0.4600024589597397 2.9459406532186247 0.0032197416944441 0.94421877373607 0.1600927120293072 108 Q99829,P55735,P42785,Q9NXN4,Q8NHS3,O75503,P36543,Q9UIQ6,Q01650,Q8WTV0,Q8NF37,Q9Y487,Q93050,O15260,P10253,O95772,O95721,Q8N511,P10619,Q8IV08,Q99523,O15118,P11117,Q14108,P42892,P04062,P07602,Q07954,Q9Y2T2 29 +Azurophil granule 0.503859917504023 2.7577452914747353 0.0058201528536365 0.9946156278870693 0.1929272890372123 64 Q99829,P68371,P04066,Q9BTY2,P42785,P08236,P06865,P16278,O00584,Q8NF37,P06280,O15260,P10253,O95721,P10619,P50995,Q92820,P07602,P07437,Q9H7Z7,P17900 21 +Nls dependent protein nuclear import complex 0.89749030825047 2.5525457328791203 0.0106938869339789 0.9999337829352426 0.2149025971445162 7 O00505,O00629,P52294 3 +Azurophil granule lumen 0.5456891016090952 2.521877110323424 0.0116730480167277 0.9999727057107032 0.2149025971445162 39 P16278,P10619,O00584,P06280,Q9BTY2,Q92820,P08236,P07437,Q9H7Z7,P17900 10 +Proteasome core complex beta subunit complex 0.8894830659536515 2.5190972052463905 0.0117656170503701 0.9999749005543592 0.2149025971445162 7 P28074,P20618,Q99436,P28072,P28070,P49721 6 +Proton transporting v type atpase complex 0.765074338168658 2.4388079580432227 0.0147357969549857 0.9999983030454668 0.2273885909433142 11 Q9Y487,Q93050,Q8N511,P36543 4 +Tim23 mitochondrial import inner membrane translocase complex 0.9032222236346584 2.38660626092016 0.0170046923861548 0.9999997844524888 0.2494950768132559 6 Q99595 1 +Nucleocytoplasmic transport complex 0.801688523991355 2.344433823740929 0.0190559918511117 0.999999966766523 0.2664861360428906 9 O00505,O00629,P52294 3 +Collagen containing extracellular matrix 0.5566944826458526 2.318201557702228 0.0204383694234171 0.9999999905934558 0.2814206251378207 25 Q32P28,P07602,P04083,Q08380,O14936,P07858 6 +Pore complex 0.7538569357115996 2.1221657963202465 0.0338238177073464 0.9999999999999578 0.3931469720529228 9 P21796 1 +Intrinsic component of organelle membrane 0.3981505046821365 2.0903792420067577 0.0365837460648594 0.9999999999999968 0.414461426937332 109 Q9NQC3,Q9Y282,Q99595,O60830,P04439,Q9Y512,Q9Y287,P01889,O43505,Q15629,O75844,P10321,Q8TCT9,O15118,P42892,Q9Y679,Q14739,Q86XL3,Q9Y2R0,Q7L0J3 20 +Anaphase promoting complex 0.7143981278448999 2.052903323674661 0.0400819546201736 1.0 0.4270636831554212 10 Q9UJX4,O60566,Q96DE5,Q9UJX6,Q13042,Q9UJX3,Q9H1A4,Q9UJX2 8 +Copii vesicle coat 0.7058639492497127 2.0106141307098064 0.0443662303179326 1.0 0.4617183271459268 10 Q15437 1 +Intrinsic component of mitochondrial inner membrane 0.5082609108883925 1.9751219330393783 0.0482543123707879 1.0 0.4798623285761687 27 Q99595,O60830,Q9Y2R0 3 +Proteasome complex 0.4659326683548906 1.9699760634561672 0.0488411139344366 1.0 0.4803604062782509 46 P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P60900,P49720 9 +Schaffer collateral ca1 synapse 0.6565024572392661 1.962840372112603 0.0496647250816704 1.0 0.4831514016097284 12 Q9BVA1,O14936,Q9UQB8 3 +Postsynaptic cytosol 0.8645051297768106 1.9399632657995056 0.0523841543597805 1.0 0.504127076903264 5 Q9UQB8 1 +Vesicle lumen 0.3856850701710166 1.905102141806528 0.0567667950629466 1.0 0.5348029640140767 110 P16278,Q8NBX0,P10619,Q9NTK5,O00584,P20618,O75874,Q99436,P68371,Q92820,Q9BTY2,P06280,P08236,Q08380,P07437,Q9NUQ9,Q9H7Z7,P17900 18 +Lumenal side of membrane 0.7049218715388863 1.8889176910324197 0.0589028585637172 1.0 0.5491464418179889 9 P10321,P01889,P10619,P04439 4 +Cytosolic region 0.7405710459645275 1.8718026639804808 0.0612339095896128 1.0 0.5552920644654699 7 Q9UQB8 1 +Intrinsic component of golgi membrane 0.6933882616946453 1.8331054099728523 0.066786896747957 1.0 0.5639082319756747 9 Q9Y282 1 +Endopeptidase complex 0.433862704501297 1.798024508975667 0.0721731239331444 1.0 0.5819364497312098 51 P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P60900,P49720 9 +Side of membrane 0.4155320578165098 1.770024468902622 0.0767230646282939 1.0 0.6076738304630359 61 P04439,P10321,P55899,Q01650,Q8TCT9,P10619,Q9NR28,P01889,Q4VCS5,P04083,P62942,P08183,P42892,P17900,P07858 15 +Endoplasmic reticulum lumen 0.4236418714692234 1.7590481334803705 0.0785693333744939 1.0 0.6144110854199416 53 Q14257,O43852,O95881,Q32P28,O00584,O75718,Q9BTY2,Q06481,Q96AY3,Q9UBS4,O43493,Q6P179,Q8NBJ4,P13674 14 +Platelet alpha granule 0.6041108703249948 1.7568306696403913 0.0789466757802159 1.0 0.6144110854199416 13 Q9NUQ9,Q8NBX0,Q06481 3 +Cytoplasmic stress granule 0.4434016389368793 1.688208416464689 0.0913712281571337 1.0 0.6388847593799585 43 P67809,Q06787,P11940,Q92615,Q13310,Q71RC2,P61978,Q9Y520,Q14671,P31483,Q9HCE1,Q14258,Q01085,Q9BWF3,Q14011 15 +Mcrd mediated mrna stability complex 0.7983352606334205 1.6739744974231583 0.0941356115352545 1.0 0.642583321450287 5 Q14103,O60506,Q9H074 3 +Early endosome membrane 0.4446052165850971 1.6636911595469115 0.0961741638595419 1.0 0.642583321450287 41 P10321,Q92783,Q8IV08,P01889,O14964,Q06481,Q9UKG1,P04083,Q9H223,P04439 10 +Copii coated er to golgi transport vesicle 0.4578555820194909 1.641577435133688 0.1006776071957018 1.0 0.642583321450287 32 P10321,P55735,Q9Y282,Q969M3,P01889,O15027,Q15437,Q12907,P04439 9 +Proton transporting two sector atpase complex 0.5116625053928121 1.6389013957248115 0.1012337970106038 1.0 0.642583321450287 21 Q9Y487,Q93050,P36543,O75964,Q8N511 5 +Peptidase complex 0.4039619787211245 1.6237964425677665 0.1044192595607054 1.0 0.6476775070849106 57 P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P60900,P49720 9 +Cis golgi network 0.666985787470562 1.6153518944943412 0.1062345114876257 1.0 0.6476775070849106 8 O00461,Q14789,Q9NPR9 3 +Intrinsic component of plasma membrane 0.4005979759246121 1.6146878186796756 0.1063783168061249 1.0 0.6476775070849106 63 P10321,P15260,Q8WTV0,P11717,Q9NR28,Q07954,P01889,O15118,Q12907,Q9UIQ6,P53985,Q8NBJ4,O43657,O00264,P04439 15 +Proton transporting v type atpase v1 domain 0.6834476736392084 1.6112374819652415 0.1071279711982384 1.0 0.6478346906920502 7 Q15904,P21283,P36543 3 +Intrinsic component of endoplasmic reticulum membrane 0.4321672808114498 1.600815830089892 0.1094177163812168 1.0 0.6565060952032576 44 P10321,Q9Y679,Q9NQC3,Q9Y282,P01889,Q86XL3,Q15629,O75844,P04439 9 +Host cellular component 0.7797097672677881 1.5980630112473484 0.1100289545033392 1.0 0.6565060952032576 5 O00505 1 +Crd mediated mrna stability complex 0.7147472058733677 1.5921436437685017 0.1113524325930264 1.0 0.6600028289454215 6 O60506 1 +External side of plasma membrane 0.5086868110363694 1.5478000858031766 0.1216704358472859 1.0 0.680505094687553 20 P55899,Q4VCS5,P04083,P08183,P42892,P07858 6 +Outer mitochondrial membrane protein complex 0.5406865561023647 1.5432563338672374 0.1227685938207807 1.0 0.680505094687553 16 Q13505,Q8N4H5,Q9Y512,Q9NS69 4 +Presynaptic cytosol 0.7650060180029166 1.537859286581214 0.1240830238527759 1.0 0.681314762872604 5 Q9UQB8 1 +Caveola 0.5509234899136193 1.5325115880836315 0.1253962402349393 1.0 0.6843270427455531 14 Q8WTV0 1 +Nadh dehydrogenase complex 0.5019442540051481 1.501194163795711 0.1333053490419051 1.0 0.7124808614331956 20 O75306,Q96CU9,O43676 3 +Early endosome 0.3673768928660668 1.485396939383465 0.1374387059530413 1.0 0.7228170239547447 82 Q9UKG1,P04083,Q9UIQ6,P04439,P01889,Q9Y5X3,P10321,Q92783,Q5VW38,P11717,Q8IV08,Q92542,Q99523,Q9H223,P42858,P31751,O14964,P40818,Q02750,Q06481,Q07954 21 +Messenger ribonucleoprotein complex 0.7513114543110362 1.4815923631927057 0.1384487922646786 1.0 0.7228170239547447 5 P67809,Q06787,Q99729 3 +External encapsulating structure 0.4423497017944991 1.4798619673557347 0.1389100872851576 1.0 0.7228170239547447 30 Q32P28,P07602,P50995,P04083,Q08380,O14936,P07858,P17931,Q92896 9 +Inner mitochondrial membrane protein complex 0.3814047282539919 1.443882909647069 0.1487719147918991 1.0 0.7263248147167446 69 Q9Y512,Q96CU9,P21912,O43676,Q99595,O60830,O75306,P47985,O75964 9 +Lumenal side of endoplasmic reticulum membrane 0.6469782119219414 1.441913457191086 0.1493267893575305 1.0 0.7263248147167446 7 P10321,P01889,P04439 3 +Neuronal ribonucleoprotein granule 0.8740213523131681 1.4383680929791094 0.1503296407933114 1.0 0.7263248147167446 2 Q99729 1 +Platelet alpha granule lumen 0.6134312801737254 1.438325544281731 0.1503417073426012 1.0 0.7263248147167446 9 Q9NUQ9,Q8NBX0 2 +Nuclear ubiquitin ligase complex 0.5296261685413247 1.4369240959530951 0.1507395623652634 1.0 0.7263248147167446 15 Q9UJX4,O60566,Q96DE5,Q9UJX6,Q8IXK0,Q99496,Q9NXR7,Q13042,Q9UJX3,Q9H1A4,Q9UJX2 11 +Respirasome 0.4208406929608672 1.4277471587460222 0.1533646470964034 1.0 0.732604054898637 40 P21912,Q96CU9,O43676,O75306,P47985,Q6DKK2 6 +Ciliary membrane 0.6755098688681498 1.4193291853020618 0.1558030671977193 1.0 0.7339144481155725 6 O14936 1 +Outer membrane 0.370930670240217 1.380006832042756 0.1675845412773902 1.0 0.760573922085471 74 P30536,Q8N2A8,Q9Y512,Q9NS69,Q07820,Q13505,Q8N4H5,Q8N0X7,P21796,Q9Y6C9,P09601,P45880,O00264,O43169 14 +Endosome lumen 0.917425146212136 1.371283057730172 0.1702867350412349 1.0 0.760573922085471 3 Q9UIQ6 1 +Prefoldin complex 0.7171276993492666 1.340484459593548 0.1800878933355134 1.0 0.7770679048732262 5 P61758,O15212,Q9NQP4 3 +Envelope 0.2826266113329395 1.3360276947740926 0.1815402213031054 1.0 0.7770679048732262 425 P30536,P55735,Q96CU9,Q9NS69,Q9NQC3,Q99595,O60830,Q70HW3,Q8TD16,P21796,Q5BJF2,Q9H1E5,P45880,Q567V2,O75964,P57740,O00264,O00505,Q8N2A8,Q9Y512,O00584,O43676,Q96A26,Q96BR5,O00629,P52294,Q9H061,O15173,O75844,Q8NFQ8,P80303,Q9UBX3,Q9H2D1,O75179,P21912,Q9NR28,Q8N0X7,O43772,P09601,Q9Y619,O15118,Q99543,P67809,Q14739,Q07820,Q8N4H5,Q8NFH4,Q9Y6C9,P62995,O75306,P47985,P07437,Q6DKK2,Q9Y6M9,Q9Y2R0,O43169 56 +Azurophil granule membrane 0.4688500671910884 1.3347140293303748 0.1819699601071394 1.0 0.7770679048732262 21 Q99829,P07602,Q8NF37,P42785,O15260,P10253,O95721 7 +Nuclear outer membrane endoplasmic reticulum membrane network 0.3621637921415708 1.3011344348096086 0.1932124428253967 1.0 0.7853771696540418 262 P55735,P07099,Q9NQC3,Q8TB61,Q9Y282,Q15392,Q8TD16,Q5BJF2,P48449,O95197,Q96N66,Q6P179,Q15800,Q96G23,Q9BQE5,O00264,P30519,P04439,P50402,Q8NF37,Q9UKR5,P04844,P01889,Q9BZF1,Q9NZ08,O15260,P51648,O95772,P62942,Q12907,Q15629,O75844,Q8NFQ8,P37268,Q8N511,P10321,O43852,Q8TCT9,Q16850,O60725,Q8IV08,O43865,O15270,Q9P2W9,P09601,Q99523,Q14108,Q9Y679,Q9HD20,Q14739,Q86XL3,Q96PC5,Q15437,Q06136,Q15904,Q99943,P43307 57 +Cullin ring ubiquitin ligase complex 0.4185526993567401 1.291196079412813 0.1966356942661096 1.0 0.7891881003056865 31 Q15369,Q16531,Q9UJX4,O60566,Q96DE5,Q9UJX6,Q9Y3I1,Q92990,Q9HB71,Q9NV06,Q96K76,Q13042,Q9UJX3,Q9H1A4,Q9UJX2 15 +Lipid droplet 0.4214232772506421 1.285200421691651 0.1987222563232398 1.0 0.7928698689900473 28 Q01105,Q9Y679,Q8N0X7,P48449,Q8NBX0 5 +Ciliary transition zone 0.7027806345190093 1.2810660236091318 0.2001704766266052 1.0 0.7928698689900473 5 A6NIH7 1 +Mhc protein complex 0.8867924528301944 1.258940457750245 0.208051839158192 1.0 0.8014806285351754 3 P01889,P04439 2 +Mhc class i protein complex 0.8867924528301944 1.258940457750245 0.208051839158192 1.0 0.8014806285351754 3 P01889,P04439 2 +Er membrane insertion complex 0.8861473032898652 1.256577300683526 0.2089067385809557 1.0 0.8014806285351754 3 P46379 1 +Nuclear pore outer ring 0.5756364829291096 1.2479735945098576 0.2120407273563318 1.0 0.8075593658890085 9 P55735,P57740,Q9BW27,Q8NFH4 4 +Ribonucleoprotein granule 0.3340894387665002 1.2392694219876297 0.2152457387837842 1.0 0.8108761295944007 99 Q9NRW3,Q16637,P51116,Q13310,Q08J23,Q14258,P11940,Q92797,Q14671,P31483,P51114,Q92615,Q71RC2,O15514,P61978,Q99729,Q9HCE1,Q9BWF3,Q13501,Q14011,P51991,P67809,Q06787,Q01085,Q9Y520,P19474,P07437,P60900,Q96C86 29 +Golgi membrane 0.3361591231271316 1.1870729555576094 0.2351988448067306 1.0 0.8488022826694511 109 Q86SF2,Q8TB61,Q9Y282,Q15392,Q10472,O95197,Q8N6H7,P04439,Q7LGA3,Q8NF37,Q9Y287,P01889,O43505,Q8IUD2,O15260,Q12907,O95721,Q6RW13,P10321,P11717,Q8IV08,O00461,Q9P2W9,O15027,Q14108,Q9BW83,Q92896,P35613,Q9H7Z7,P42345 30 +Esc e z complex 0.8060498220640577 1.1596462091505182 0.2461928790500269 1.0 0.8607133857413053 2 Q92769 1 +Integral component of synaptic vesicle membrane 0.7634981004742754 1.139325344782399 0.2545674810939879 1.0 0.8670141163644701 4 Q7L0J3 1 +Secretory granule membrane 0.3571689970847689 1.1062068391381397 0.2686370033510641 1.0 0.8806964029274812 61 P10321,P07602,Q8NF37,P01889,Q93050,Q06481,P42785,O15260,P10253,O95721,O00264,P30519 12 +Proteasome core complex alpha subunit complex 0.5695943914393442 1.0780240648467938 0.2810230168778727 1.0 0.8827785623504275 7 P60900 1 +Ficolin 1 rich granule 0.3301042841800211 1.0746168113901615 0.2825463220204061 1.0 0.8827785623504275 86 P16278,O75874,P20618,Q99436,P14174,Q93050,P42785,P08236,P09960,P07858 10 +Membrane microdomain 0.3529190961340109 1.0557353164025185 0.2910891573996683 1.0 0.8827785623504275 55 P50897,Q8WTV0,O14773,P21796,P09601,O15118,P30154 7 +Cleavage furrow 0.4708876888692055 1.0509811702953158 0.2932672380603542 1.0 0.8827785623504275 14 Q53EZ4,O75935 2 +Endoplasmic reticulum exit site 0.4506555884266024 1.0441905375277396 0.2963972440001061 1.0 0.8827785623504275 18 Q969M3,Q96PC5,O15027,Q15437,P04439 5 +Extrinsic component of endosome membrane 0.82627269490922 1.0385505107555493 0.2990138322836762 1.0 0.8827785623504275 3 P04083,Q9Y5X3 2 +Origin recognition complex 0.5607652615937899 1.036425907744336 0.3000034888846057 1.0 0.8827785623504275 7 Q9Y619,Q9UFC0 2 +Dendritic shaft 0.8247074110554927 1.032901476233071 0.3016500078740016 1.0 0.8827785623504275 3 Q9UQB8 1 +Cul4a ring e3 ubiquitin ligase complex 0.7740213523131647 1.030073319148424 0.3029755888497036 1.0 0.8827785623504275 2 Q92990 1 +Ficolin 1 rich granule membrane 0.4541282587372914 1.0297753782645136 0.3031154614004585 1.0 0.8827785623504275 17 Q93050,P42785 2 +Plasma membrane raft 0.4421426179497631 1.0291829811581743 0.3033936980907121 1.0 0.8827785623504275 19 Q8WTV0 1 +Intrinsic component of mitochondrial membrane 0.3789450737103221 1.0258384887614715 0.3049677205995893 1.0 0.8827785623504275 39 Q99595,O60830,Q9Y2R0 3 +Vacuolar proton transporting v type atpase v0 domain 0.8214976411548047 1.021328719310285 0.3070987241587706 1.0 0.8827785623504275 3 Q9Y487 1 +Proton transporting v type atpase v0 domain 0.8214976411548047 1.021328719310285 0.3070987241587706 1.0 0.8827785623504275 3 Q9Y487 1 +Proton transporting two sector atpase complex proton transporting domain 0.5286122034784914 1.009927182503188 0.3125301783479948 1.0 0.8827785623504275 9 Q9Y487,O75964 2 +Transporter complex 0.3674777895416579 1.0019525699772776 0.3163665008387051 1.0 0.8827785623504275 46 Q96CU9,O43676,Q9C0H2,O75306,P47985,Q9Y6M9 6 +Protein phosphatase type 2a complex 0.6316050498176915 0.9865702580370797 0.323853356681794 1.0 0.8918423207083251 5 P30154 1 +Ubiquitin ligase complex 0.3443604212621435 0.9606019291228484 0.3367523583485154 1.0 0.9127613929751892 55 Q15369,Q5VTR2,Q9Y3I1,Q96GG9,Q96P70,Q9H1A4,Q9UJX2,Q9UBS8,Q8TEY7,O60566,Q92990,Q13042,Q96DE5,Q8IXK0,Q9NXR7,Q96K76,Q9HB71,Q9UJX3,Q9Y679,Q9UJX4,Q9UJX6,Q99496,Q9NV06,Q16531 24 +Lateral plasma membrane 0.4280007207610172 0.9328370844902978 0.3509040906661342 1.0 0.9291691158171308 19 P04083,P53985,P30153,Q12955 4 +Nuclear stress granule 0.792560336429214 0.91778520103795 0.3587313315009317 1.0 0.9387852096296312 3 Q92797 1 +Cortical endoplasmic reticulum 0.739501779359431 0.8929865043449342 0.3718643999116826 1.0 0.9537264498406874 2 P50402 1 +Brisc complex 0.7809478763992737 0.8767125478165034 0.3806427895768112 1.0 0.9537264498406874 3 Q9NXR7 1 +Beta catenin destruction complex 0.6931462440458731 0.8731392829331366 0.3825871645111816 1.0 0.9537264498406874 4 Q9HB71,Q9UJX6 2 +Ciliary basal body 0.4406636979156549 0.8694546193478541 0.384598519363845 1.0 0.9537264498406874 14 Q15154,P28070,Q8IUD2,Q9BZH6,Q15691,Q14679,Q9UPT5 7 +Nbaf complex 0.5241696968920294 0.8648961725370115 0.3870957785447064 1.0 0.9537264498406874 7 Q969G3 1 +Phagocytic cup 0.6889705707441114 0.8576084456231784 0.3911087099359682 1.0 0.9537264498406874 4 P04083 1 +Cell surface 0.3297705480175806 0.8458352026021213 0.3976446843627812 1.0 0.9537264498406874 72 P14174,P04083,P07858,P04439,P55899,Q01650,Q8WTV0,P11233,Q9HDC9,P01889,Q12907,Q13685,P10321,Q8TCT9,P11717,Q4VCS5,Q12955,Q99523,P08183,P42892 20 +Er to golgi transport vesicle membrane 0.4005585241401758 0.8449824383410358 0.3981206443292542 1.0 0.9537264498406874 21 P55735,P01889,Q15437,P04439 4 +Epsilon dna polymerase complex 0.7661742335026547 0.8249465796329278 0.4094019198737944 1.0 0.9537264498406874 3 Q9NR33 1 +Keratin filament 0.716014234875443 0.8019055802872788 0.4226075779328417 1.0 0.9575538791136542 2 P58107 1 +Photoreceptor outer segment 0.581507942838433 0.7828808642161332 0.4336970756170653 1.0 0.965569359893715 5 Q15555 1 +Lewy body 0.7464723614808861 0.7569092766742559 0.4491042172603317 1.0 0.9696022450647468 3 Q13501 1 +Oxidoreductase complex 0.3302691176157168 0.7554240721504564 0.4499945741272919 1.0 0.9696022450647468 53 P21912,Q96CU9,O43676,P23378,O75306,P47985,Q9Y6M9,P13674,O43169 9 +Organelle subcompartment 0.3144519178144508 0.7536659320349948 0.4510498434425867 1.0 0.9696022450647468 313 P55735,P07099,Q9NQC3,Q9Y282,Q15392,Q5BJF2,P48449,O95197,O43493,Q6P179,Q15800,Q96G23,Q9BQE5,O00264,P30519,P04439,Q8NF37,P01889,Q9BZF1,O15260,O95772,P62942,Q9NPR9,Q15629,O75844,Q8NFQ8,Q8N511,P10321,O43852,Q8TCT9,Q16850,P11717,O60725,Q8IV08,O00461,O43865,O15270,Q9P2W9,P09601,Q14108,P04062,Q9Y679,Q9HD20,Q14739,Q86XL3,Q96PC5,Q15437,Q06136,Q15904,P43307 50 +Chromaffin granule membrane 0.7032028469750866 0.7531862928014477 0.4513379750696986 1.0 0.9696022450647468 2 P20073 1 +Chromaffin granule 0.7032028469750866 0.7531862928014477 0.4513379750696986 1.0 0.9696022450647468 2 P20073 1 +Cytoplasmic ubiquitin ligase complex 0.4967325984497693 0.7382007670699955 0.4603924568288211 1.0 0.9718189831646108 7 Q9Y679 1 +Neuron spine 0.3545138364767822 0.7331991960632254 0.4634369456193796 1.0 0.9736527378623115 28 Q06787,P62136,P51116,P40818,Q14247,Q14168,Q9UQB8,P51114 8 +Podosome 0.443738878761175 0.7291986567328557 0.4658801527808922 1.0 0.9743967684089736 11 P61978,Q14247,Q07157 3 +Myosin ii complex 0.6533976921103005 0.7272754698763669 0.4670572219524578 1.0 0.9743967684089736 4 P60660 1 +Nucleoid 0.3507335485281099 0.7198336261642643 0.4716274384837642 1.0 0.9796244816690672 32 P21796 1 +Endocytic vesicle membrane 0.3444336149175311 0.7132880579532106 0.4756675256609366 1.0 0.9828682359240252 40 P10321,Q8WTV0,P11717,Q9Y487,P01889,Q93050,Q06481,O43493,Q14108,P04439 10 +Cul4 ring e3 ubiquitin ligase complex 0.4906355521773312 0.7103991609960285 0.4774566433142286 1.0 0.9828682359240252 7 Q9NV06,Q92990 2 +Acrosomal membrane 0.690747330960859 0.706581826914775 0.4798263856957125 1.0 0.9828682359240252 2 P35613 1 +Secretory granule 0.3339227706135255 0.7023312286914123 0.4824726223489897 1.0 0.9828682359240252 215 Q9NTK5,O75874,P68371,P14174,Q9BTY2,P42785,P45880,P08236,Q9UQB8,P06865,O00264,P30519,P07858,P16278,P09960,O00584,Q8NF37,Q9Y487,P01889,Q93050,P06280,O15260,P10253,O95721,P10321,P10619,Q99436,P11717,Q92820,P42892,Q9NUQ9,P07602,P20618,Q06481,Q08380,P07437,Q8NBX0,Q9H7Z7,P17900 39 +Rna cap binding complex 0.5598387181841586 0.696938269111129 0.4858414269352047 1.0 0.9828682359240252 5 Q06787 1 +Neuron projection terminus 0.4112856891637593 0.6961838609321368 0.4863136934845951 1.0 0.9828682359240252 14 Q06787,Q7L576,P61421,Q9UQB8 4 +Cilium 0.3143137818890771 0.6955548651645358 0.4867076403660402 1.0 0.9828682359240252 76 A6NIH7,Q15555,Q92973,O14936,O43924,P21266,Q8IUD2,P04083,P28070,Q9NUQ9,Q14679,Q9BW83 12 +Coated vesicle 0.3053427837026087 0.6780177629854652 0.4977604307293122 1.0 0.9828682359240252 83 P10321,P55735,Q9Y282,Q5VW38,P11717,P01889,Q15437,Q14108,O43493,P42892,Q8N511,P04439 12 +Dopaminergic synapse 0.6814946619217086 0.6725013308301322 0.5012645931759918 1.0 0.9828682359240252 2 P20337 1 +Prp19 complex 0.444684151677828 0.6589659476599472 0.5099176356483386 1.0 0.9843007339274918 10 Q9P013,Q8WYA6,Q9BZJ0,Q9NW64 4 +Filopodium 0.3439893324392422 0.6494835657160326 0.5160258655915664 1.0 0.9843007339274918 26 P51114,Q9UQB8 2 +Rough endoplasmic reticulum 0.3437447234945626 0.6479937583075481 0.5169889873135396 1.0 0.9843007339274918 29 Q5BJF2 1 +Neuron projection cytoplasm 0.3426407853999113 0.6460065496117687 0.5182751137527264 1.0 0.9843007339274918 31 Q14168,Q9UQB8,Q99729,Q92572,Q9Y2T2 5 +Mib complex 0.4408821183353277 0.639796482084975 0.5223049199905785 1.0 0.9843007339274918 10 Q13505,Q9Y512 2 +Neuromuscular junction 0.3989230272723659 0.6380962266624963 0.5234110426963463 1.0 0.9843007339274918 15 Q12955,Q14168,P10644,P46109,Q7L0J3 5 +Tight junction 0.370820076735222 0.636657344652028 0.5243480637227307 1.0 0.9843007339274918 21 Q07157,P16989,Q4VCS5,Q12955,Q92797,Q9Y624 6 +Sperm annulus 0.6708185053380773 0.633806049611307 0.5262074046450744 1.0 0.9843007339274918 2 Q16181 1 +Endoplasmic reticulum golgi intermediate compartment membrane 0.3391184207899101 0.6142855308363899 0.5390266621950897 1.0 0.9843007339274918 25 O15260,Q8N511,Q9Y282 3 +Basal part of cell 0.3301603007913573 0.6125903050393329 0.5401472702886587 1.0 0.9843007339274918 44 Q01650,Q07157,Q12955,P42785,P04083,Q14168,P35613,Q6P4Q7,Q07954,P53985,O14936 11 +Extrinsic component of organelle membrane 0.445729573646801 0.5993546460093498 0.5489364144047348 1.0 0.9843007339274918 9 P04083,P40818,Q9Y5X3,P62942 4 +Microtubule end 0.4445123835015666 0.5935515461278089 0.5528120971227588 1.0 0.9843007339274918 9 Q15691,Q15555,Q96R06 3 +Cop9 signalosome 0.428261343464847 0.5768536485389463 0.5640383246823766 1.0 0.9843007339274918 10 Q99627,Q92905,Q9BT78,P62993,Q9UNS2,Q7L5N1 6 +Gpi anchor transamidase complex 0.6085648404127406 0.5699385685010682 0.5687193646518838 1.0 0.9843007339274918 4 Q96S52,O43292 2 +Endocytic vesicle 0.301115576747855 0.5658379403211274 0.5715039523384857 1.0 0.9843007339274918 79 P10321,Q8WTV0,P11717,Q9Y487,P01889,Q93050,O00461,O14964,Q06481,P50995,Q4VCS5,P08670,Q9UKG1,Q14108,O43493,Q07954,Q9H223,P04439 18 +Microtubule plus end 0.4454195227906146 0.5506866625348387 0.5818484891438493 1.0 0.9843007339274918 8 Q15691,Q15555,Q96R06 3 +Nuclear envelope lumen 0.6017714171023942 0.5469855234509289 0.5843886778011902 1.0 0.9843007339274918 4 P07437,P11717 2 +Late endosome membrane 0.3308829146397761 0.5468673411161629 0.5844698743730272 1.0 0.9843007339274918 30 Q8IV08,O15118,Q14108,O14964 4 +Main axon 0.4430842732459071 0.5401665596353886 0.5890821720762109 1.0 0.9863390158092528 8 Q14168,Q12955 2 +Apical plasma membrane 0.3231398713305328 0.5257885131994953 0.5990351564531395 1.0 0.9863390158092528 41 P04083,P08183,P36543,P53985,P07858 5 +Myosin filament 0.6391459074733076 0.5235731805723369 0.6005754392996314 1.0 0.9863390158092528 2 P35580 1 +Phagocytic vesicle membrane 0.3398285386851772 0.5142140094613021 0.607102374090196 1.0 0.9863390158092528 23 Q9Y487,P01889,Q06481,P04439 4 +Pinosome 0.6710089746091722 0.511193646685909 0.6092154669994638 1.0 0.9863390158092528 3 Q06481 1 +Specific granule membrane 0.4016513504209409 0.5095943606948258 0.610335675493213 1.0 0.9863390158092528 11 P30519 1 +Magnesium dependent protein serine threonine phosphatase complex 0.4444040347455399 0.5060264996957899 0.6128380467711871 1.0 0.9863390158092528 7 P30154 1 +Nata complex 0.6320284697508862 0.4998649773792172 0.6171701542272405 1.0 0.9863390158092528 2 Q9BXJ9 1 +Cul4b ring e3 ubiquitin ligase complex 0.625622775800719 0.4788977724653672 0.632011355725457 1.0 0.9863390158092528 2 Q16531 1 +Mitotic spindle microtubule 0.6601878133374702 0.4785124989454208 0.6322854803569886 1.0 0.9863390158092528 3 O94927 1 +Inflammasome complex 0.6249110320284774 0.4765904138979683 0.6336538108668368 1.0 0.9863390158092528 2 Q9H6R0 1 +Nlrp3 inflammasome complex 0.6249110320284774 0.4765904138979683 0.6336538108668368 1.0 0.9863390158092528 2 Q9H6R0 1 +Nuclear inner membrane 0.3467092507849039 0.4744973290577773 0.6351453021745816 1.0 0.9863390158092528 21 P50402,Q14739,Q9H1E5,P62995,O75844,Q5SNT2 6 +Intercellular bridge 0.3618441993008611 0.4726813535248181 0.6364405316955588 1.0 0.9863390158092528 18 Q13432,Q9UJX6,P21266,Q53EZ4,Q13685 5 +Striated muscle thin filament 0.576849426711922 0.4652633753864095 0.6417428590704115 1.0 0.9863390158092528 4 P09493 1 +Myofilament 0.576849426711922 0.4652633753864095 0.6417428590704115 1.0 0.9863390158092528 4 P09493 1 +Presynaptic active zone cytoplasmic component 0.4974271947797486 0.4624327532586579 0.643771015854744 1.0 0.9863390158092528 5 Q8IUD2 1 +Nuclear periphery 0.2982315895171892 0.4521706802148282 0.6511460285040465 1.0 0.9863390158092528 57 P60900,Q96FV9,P08670,Q5BKZ1,O60216,O43823,Q9ULX6,P57740,O14936,P22626 10 +Coated vesicle membrane 0.3025907450987775 0.4491909083983308 0.6532939454052356 1.0 0.9876656775974424 52 P10321,P55735,P01889,Q15437,O43493,Q14108,Q8N511,P04439 8 +Spectrin associated cytoskeleton 0.6450008595747716 0.4340009239966318 0.6642877700729415 1.0 0.9936464292875508 3 Q12955 1 +Nurd complex 0.4180446951835334 0.4302732868408217 0.6669968565919198 1.0 0.9949369777496138 8 O95983 1 +Pigment granule 0.2960291518421558 0.4232798718310336 0.6720910780493319 1.0 0.995837169523183 59 O14773,Q93050,Q92820,P55209,P07858 5 +Ficolin 1 rich granule lumen 0.295195535693366 0.4193165922266792 0.6749847720137381 1.0 0.995837169523183 69 P16278,O75874,Q99436,P20618,P14174,P08236,P07858 7 +Organelle envelope lumen 0.3142894068866756 0.4183628178698912 0.6756818674927354 1.0 0.995837169523183 31 P36404,P52888,O00584,P11717,Q9NR28,Q96BR5,O95831,O14925,Q96AY3,P07437,Q9HB71,Q9BYT8 12 +Vesicle membrane 0.316739287370637 0.417200346638421 0.6765318716715074 1.0 0.995837169523183 230 Q99829,P55735,P42785,Q9UKG1,P04083,O43493,Q9UIQ6,O00264,P30519,P04439,P55899,Q8WTV0,Q8NF37,Q9Y287,P11233,Q9Y487,P01889,Q93050,O43924,Q9Y5X3,O15260,P10253,O95772,O95721,Q6RW13,Q8N511,P10321,Q92783,P11717,Q8IV08,O00461,Q92542,Q99523,O15027,O15118,Q15750,Q14108,P42892,Q9H223,P17931,P07602,P42858,Q5KU26,O14964,P40818,Q06481,P42356,Q15437,Q15904,Q07954,Q92572,Q9Y2T2,Q7L0J3 53 +Ciliary tip 0.4180509821437913 0.3967745117887916 0.6915337478672359 1.0 0.995837169523183 7 Q15555 1 +Histone pre mrna 3 end processing complex 0.6293282647319014 0.3898694633441425 0.6966330754157626 1.0 0.995837169523183 3 O60506 1 +Endosome membrane 0.2851570789643071 0.3890707369566704 0.6972238199056784 1.0 0.995837169523183 116 P04083,P04439,P55899,Q9Y287,Q9Y487,P01889,Q93050,O95772,P10321,Q92783,P11717,Q8IV08,O00461,Q99523,O15118,Q15750,Q14108,P42892,O14964,Q06481,Q15904 21 +Cul2 ring ubiquitin ligase complex 0.5521107842993993 0.3885986736145056 0.6975730481143467 1.0 0.995837169523183 4 Q15369 1 +Glutamatergic synapse 0.2911784001338812 0.3830086164323366 0.701713375359148 1.0 0.995837169523183 56 P62136,P40818,Q13363,P52294,P30153,P35080,P10644,P07737,Q9UQB8,P51114,Q7L0J3 11 +Pole plasm 0.6251334994660096 0.3783893815032696 0.7051413551824133 1.0 0.995837169523183 3 Q9HCE1,P42694 2 +Tertiary granule 0.3066516744823084 0.3758007624692699 0.7070650209182985 1.0 0.995837169523183 39 O75874,Q93050,Q92820,P42785,P09960 5 +Mitotic spindle astral microtubule 0.6223529620329709 0.3708600167060036 0.7107417968627543 1.0 0.995837169523183 3 Q8NI77 1 +Exocyst 0.6183319589868975 0.360086970192701 0.718782096427433 1.0 0.9973798082210116 3 O00471 1 +Perinucleolar compartment 0.6094206962975798 0.3367105560786769 0.7363351049910833 1.0 0.9979917525958396 3 Q9H2J4 1 +Blood microparticle 0.342812876445305 0.3278707328789716 0.7430094033977406 1.0 0.9979917525958396 15 Q08380,P07737,P04062 3 +Secretory vesicle 0.3109130955548299 0.3268851576143561 0.7437547474652795 1.0 0.9979917525958396 240 Q9NTK5,O75874,P68371,P14174,Q9BTY2,P42785,P45880,P08236,Q9UQB8,P06865,O00264,P30519,P07858,P16278,P09960,O00584,Q8NF37,Q9Y487,P01889,Q93050,P06280,O15260,P10253,O95721,P10321,P10619,P50897,Q99436,P11717,Q92820,P42892,Q9NUQ9,P07602,P20618,Q06481,Q08380,P07437,Q8NBX0,Q9H7Z7,P17900,Q7L0J3 41 +Phagocytic vesicle 0.2990436558483619 0.3149325278262579 0.7528128836984749 1.0 1.0 40 P10321,Q9Y487,P01889,P08670,Q93050,P50995,O14964,Q06481,P04439 9 +Synaptonemal structure 0.3964149553965742 0.3126364950985879 0.754556847940894 1.0 1.0 7 Q92791 1 +Dendritic growth cone 0.5980563067976782 0.3079336738741927 0.7581328019164877 1.0 1.0 3 Q7L576 1 +Dendrite terminus 0.5980563067976782 0.3079336738741927 0.7581328019164877 1.0 1.0 3 Q7L576 1 +Perinuclear region of cytoplasm 0.3011246264700202 0.3049315808531326 0.7604182624458811 1.0 1.0 169 Q01105,Q9H2J4,P16989,O75503,Q9UIQ6,O95684,P07858,P16278,P39687,Q8TEY7,Q9Y487,Q93050,O75935,P51114,P11717,P09601,Q99523,O15118,P42892,Q9H223,Q7L7X3,Q06787,P42858,O14976,Q15437,Q9H7Z7 26 +Apical junction complex 0.3026947214596027 0.3041878077685124 0.7609848130007832 1.0 1.0 24 Q07157,P16989,Q4VCS5,Q12955,Q92797,Q9Y624 6 +Pcg protein complex 0.3898922007307478 0.2884384635786526 0.7730111285143737 1.0 1.0 7 Q15022,Q8IXK0,Q99496,Q92769 4 +Nuclear exosome rnase complex 0.365728303228935 0.2882443952874988 0.7731596676360724 1.0 1.0 10 Q5RKV6,Q96B26 2 +External side of apical plasma membrane 0.5863919815196055 0.2796590120281143 0.7797391276356944 1.0 1.0 3 P08183 1 +Glial cell projection 0.5123930710082152 0.2768337930212836 0.781907731752453 1.0 1.0 4 Q06787 1 +Endoplasmic reticulum golgi intermediate compartment 0.2894052506189528 0.2757875919386051 0.782711214466516 1.0 1.0 48 Q14789,Q9Y217,Q02818,Q9Y282,Q96RQ1,Q10472,O15260,Q15904,Q12907,P80303,Q8N511 11 +Ion channel complex 0.3384951478241277 0.2694624514708558 0.7875738332919591 1.0 1.0 13 Q9C0H2 1 +Dendritic tree 0.2638358194191604 0.2690401361677194 0.7878987967404196 1.0 1.0 95 P51116,P62136,Q96A49,P21964,Q9UQB8,Q9UBB6,P12814,P52294,Q14247,Q13131,P51114,Q9Y296,O76024,P50897,Q00839,Q12955,Q14168,Q99729,Q7L576,Q06787,P42858,P40818,P30153,P98179,P42345,Q7L0J3 26 +Nuclear pore 0.2862563490389872 0.2672491344299885 0.7892773475975938 1.0 1.0 50 P55735,O00505,P52294,Q8TD16,Q8NFH4 5 +Cytoplasmic exosome rnase complex 0.349675022598826 0.2648238992833879 0.7911451250443093 1.0 1.0 11 Q9Y2L1,Q5RKV6,Q96B26 3 +9plus0 non motile cilium 0.3693112831103712 0.2628302379778934 0.7926814281235712 1.0 1.0 9 Q14679 1 +Apical part of cell 0.2844996506728397 0.2515296374941131 0.801404651148643 1.0 1.0 50 Q15154,Q01650,Q07157,O43865,P51790,Q13131,P04083,P08183,P36543,P53985,P21283,P61421,P07858 13 +Basolateral plasma membrane 0.2888891018582527 0.2330796438303256 0.8156995614988622 1.0 1.0 38 Q01650,Q07157,Q12955,P04083,Q14168,P35613,Q6P4Q7,Q07954,P53985,O14936 10 +Condensed chromosome centromeric region 0.2771935406149583 0.2275163411804978 0.8200222639633858 1.0 1.0 70 P55735,P63167,Q92674,Q13416,Q9UFC0,Q8WYP5,Q99661,P57740,Q9HBM1,P48729,O60566,Q9BZD4,Q12888,O75935,O43670,Q8NI77,Q9BW27,P49454,Q00839,Q96DE5,Q8IWS0,Q96ST3,Q13561,Q96DY7,O43633,Q8NFH4,Q96R06,Q8NBT2,Q12769 29 +Endoplasmic reticulum tubular network 0.3616777406683146 0.209717883786982 0.833887866676073 1.0 1.0 8 Q00765,P50402,Q9NQC3,Q12797 4 +Glycogen granule 0.5485536832615443 0.1973846951608721 0.8435265055144763 1.0 1.0 3 P62136 1 +Centriolar satellite 0.3004367915829044 0.1951734569210315 0.8452571577665482 1.0 1.0 21 Q15154,Q86UY6,Q8WXW3,Q96R06,Q53EZ4,Q9Y6A5 6 +Specific granule 0.282294764962632 0.1946415539573379 0.8456735698027926 1.0 1.0 28 Q92820,O00264,P30519 3 +Cell body membrane 0.5142348754448336 0.184922101129729 0.853290135752659 1.0 1.0 2 P20020 1 +Outer kinetochore 0.4710462392504402 0.1782917323355746 0.8584938714325321 1.0 1.0 4 O60566 1 +Juxtaparanode region of axon 0.4658914063642768 0.1674270988916429 0.8670340042750577 1.0 1.0 4 Q14168 1 +Gemini of coiled bodies 0.3987501685249023 0.1626775132648678 0.8707723529341664 1.0 1.0 5 Q16637 1 +Inclusion body 0.2747790782786249 0.158325816085121 0.874200066402999 1.0 1.0 26 P13807,Q13501,P35573,P42858 4 +Aryl hydrocarbon receptor complex 0.4975088967971446 0.1543038422825443 0.8773701678979124 1.0 1.0 2 O00170 1 +Sin3 complex 0.4571239435273189 0.1497071646668474 0.8809956553030038 1.0 1.0 4 Q96ST3 1 +Mitochondrial envelope 0.2972851595878619 0.137068692144986 0.8909764989086217 1.0 1.0 263 P30536,Q96CU9,Q9NS69,Q99595,O60830,Q70HW3,P21796,P45880,Q567V2,O75964,Q8N2A8,Q9Y512,O00584,O43676,Q9H061,Q9UBX3,Q9H2D1,P21912,Q9NR28,Q8N0X7,O43772,P09601,Q9Y619,Q07820,Q8N4H5,Q9Y6C9,O75306,P47985,Q6DKK2,Q9Y2R0,O43169 31 +Saga complex 0.484341637010667 0.1328647616032142 0.8943003359357611 1.0 1.0 2 Q9Y6J9 1 +Pronucleus 0.3830051372679525 0.1265351711580335 0.8993083102204409 1.0 1.0 5 P83916,O43823 2 +Transcription elongation factor complex 0.2959834201692485 0.122605489895659 0.9024195069390424 1.0 1.0 18 Q15369,Q9Y2F5,Q8IXH7,Q9NYV4,Q6IA86 5 +Cytoplasmic region 0.2636977527235955 0.1203181435337549 0.9042311320572872 1.0 1.0 56 Q06787,Q15555,Q13363,Q10713,P04792,Q8IUD2,Q14168,Q9UQB8,Q99729,Q92572,Q9Y2T2 11 +Proton transporting two sector atpase complex catalytic domain 0.3108416887740973 0.1136657341744696 0.9095027765956718 1.0 1.0 11 P36543 1 +Gap junction 0.4359247094987724 0.1108799699919101 0.9117115292788864 1.0 1.0 4 Q07157 1 +Female pronucleus 0.4318998116341579 0.1041566451919206 0.917045038897512 1.0 1.0 4 O43823 1 +Carboxy terminal domain protein kinase complex 0.3722835767723462 0.1040806686812851 0.9171053316871456 1.0 1.0 5 P19447,P18074,Q9NYV4,Q96T76 4 +Neuron to neuron synapse 0.2636966897130189 0.1027022857077454 0.9181992595074926 1.0 1.0 53 Q9NQC3,P51116,P52294,P55795,Q14168,Q9UQB8,P51114 7 +Postsynaptic membrane 0.2675930375872432 0.0958603662685538 0.9236314727014872 1.0 1.0 24 Q06787,P51790,Q12955,Q96CX2,Q14168,P46109,Q96A49 7 +Membrane protein complex 0.2941380192591176 0.0767860475196259 0.9387937504320653 1.0 1.0 259 P55735,Q96CU9,Q9NS69,Q99595,O60830,P21796,Q9C0H2,P45880,P36543,O75964,P04439,Q9Y512,O43676,Q9Y487,P01889,Q93050,P62942,O95721,Q8N511,Q07666,P10321,Q8TCT9,P21912,P11717,Q9NR28,O15270,Q9P2W9,Q9Y679,Q8N4H5,Q15437,Q15904,O75306,P47985,Q92572,Q9Y6M9,Q9Y2T2 36 +Chromosome centromeric region 0.2475429223103582 0.0759787151545157 0.9394360320870584 1.0 1.0 91 P55735,Q92674,O60216,Q8WYP5,Q9UFC0,Q99661,P57740,Q9HBM1,O60566,Q12888,O75935,O43670,Q8NI77,Q9BW27,P49454,Q00839,Q96DE5,Q8IWS0,P83916,Q96ST3,Q96DY7,O43633,Q06787,P30153,Q8NFH4,Q96R06,Q8NBT2,Q12769 28 +Photoreceptor inner segment 0.3303812404320275 0.0735398369330103 0.9413765445891636 1.0 1.0 6 Q15555 1 +Cdc73 paf1 complex 0.4113247863247903 0.0730163852428529 0.9417930787757416 1.0 1.0 4 Q9GZS3,Q6PD62,Q8N7H5 3 +Extrinsic component of membrane 0.2649921543645649 0.0713115784598593 0.9431497804130032 1.0 1.0 47 P30419,Q06787,Q9UJX6,Q9Y5X3,P04083,P62942,P04062,P46109 8 +Elongator holoenzyme complex 0.4086876974079034 0.0694123435240256 0.9446614039068713 1.0 1.0 4 Q6IA86 1 +B wich complex 0.3176470588235255 0.0669165259669604 0.9466481567078056 1.0 1.0 7 Q9NR30,O60264,P35659,Q9BQG0,O75533,Q9NY93 6 +Sex chromatin 0.4577640494862168 0.0635614513061681 0.949319427045778 1.0 1.0 3 Q15022 1 +Organelle inner membrane 0.2925014730655457 0.0603484703109306 0.9518780985380096 1.0 1.0 209 Q96CU9,Q99595,O60830,Q70HW3,Q9H1E5,Q567V2,O75964,Q9Y512,O43676,Q9H061,O75844,Q9UBX3,Q9H2D1,P21912,O43772,Q9Y619,Q14739,Q9Y6C9,P62995,O75306,P47985,Q6DKK2,Q9Y2R0 23 +Early phagosome 0.3942759949212171 0.051237094133452 0.9591365938057596 1.0 1.0 4 Q06481 1 +Cajal body 0.2597496284036054 0.0449197785984565 0.9641712517140936 1.0 1.0 32 Q01844,O75940,Q06787,Q16637,P22626 5 +Nucleotide activated protein kinase complex 0.3878768705788988 0.0439746560348452 0.9649246058736712 1.0 1.0 4 P10644,Q13131 2 +Late endosome 0.2548878116485836 0.0407750944902219 0.967475194559354 1.0 1.0 57 P07602,P42858,P11717,Q8IV08,O14964,O15118,O95772,Q14108 8 +Transcription factor tfiih holo complex 0.4281598239009463 0.0385842884543047 0.9692218289620786 1.0 1.0 3 P18074 1 +Sperm midpiece 0.333746389311404 0.0381238933639938 0.969588901005804 1.0 1.0 5 Q9BW83 1 +Iron sulfur cluster assembly complex 0.4268422926308285 0.0376585873054642 0.96995989510033 1.0 1.0 3 O76003,Q86SX6 2 +Synaptic membrane 0.2598304182455245 0.0347999239967242 0.9722392812379592 1.0 1.0 37 Q06787,Q92542,O14936,Q8IUD2,Q14168,Q9UQB8,P46109 7 +Cyclin cdk positive transcription elongation factor complex 0.3718861209964445 0.0337421290206945 0.9730827839846878 1.0 1.0 2 Q9NYV4 1 +Gaba ergic synapse 0.3023792040462689 0.0328337673986556 0.9738071502318602 1.0 1.0 7 Q07021,Q13363,Q7L0J3 3 +Tubular endosome 0.3770420727214695 0.0327719966808086 0.9738564096245323 1.0 1.0 4 Q9Y5X3 1 +Anchored component of plasma membrane 0.4051263794944802 0.0244543047603236 0.9804902323218 1.0 1.0 3 Q9NQX3,P36551 2 +Brca1 c complex 0.3338078291815003 0.0241748567812191 0.9807131336499072 1.0 1.0 2 P49959 1 +Golgi lumen 0.4037264013755319 0.0237284111628054 0.9810692435517684 1.0 1.0 3 O00461 1 +Chromocenter 0.3665397300372652 0.023175886343936 0.9815099733505156 1.0 1.0 4 Q06787 1 +Nuclear cyclin dependent protein kinase holoenzyme complex 0.3980326805914938 0.0209212750391139 0.98330845531035 1.0 1.0 3 Q9NYV4 1 +Pml body 0.2695381849905189 0.0182589807987431 0.9854322505871024 1.0 1.0 18 Q13501,Q9ULX6 2 +Mediator complex 0.3170644816530076 0.0166153972439332 0.9867434410297876 1.0 1.0 5 Q9NYF8,P11802,O75448,Q9Y2W1 4 +Mismatch repair complex 0.3616945532217912 0.0078224083248476 0.9937586848204608 1.0 1.0 3 P43246,P52701 2 +Exoribonuclease complex 0.2615494148119984 0.0077438398442798 0.9938213714993404 1.0 1.0 14 Q9Y2L1,Q5RKV6,Q96B26 3 +Cell division site 0.264562022132855 0.0023728418433269 0.9981067479046036 1.0 1.0 19 Q53EZ4,O75935 2 +Box h aca telomerase rnp complex 0.3278746885012479 0.0013328797008215 0.9989365161801989 1.0 1.0 3 Q9NY12,Q9NX24 2 diff --git a/msigdb_gocc/selections.json b/msigdb_gocc/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..0b04581acc465cf5c88eb5215c3a2f63e9b1e668 --- /dev/null +++ b/msigdb_gocc/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["90s preribosome", "9plus0 non motile cilium", "9plus2 motile cilium", "A band", "Acrosomal membrane", "Acrosomal vesicle", "Actin based cell projection", "Actin cytoskeleton", "Actin filament", "Actin filament bundle", "Actomyosin", "Adherens junction", "Aggresome", "Alpha dna polymerase primase complex", "Alveolar lamellar body", "Aminoacyl trna synthetase multienzyme complex", "Ampa glutamate receptor complex", "Amphisome", "Amphisome membrane", "Anaphase promoting complex", "Anchored component of membrane", "Anchored component of plasma membrane", "Anchored component of postsynaptic membrane", "Anchored component of synaptic membrane", "Anchored component of synaptic vesicle membrane", "Anchoring junction", "Annulate lamellae", "Ap 1 adaptor complex", "Ap 3 adaptor complex", "Ap type membrane coat adaptor complex", "Apical dendrite", "Apical junction complex", "Apical part of cell", "Apical plasma membrane", "Apicolateral plasma membrane", "Arp2 3 protein complex", "Aryl hydrocarbon receptor complex", "Aster", "Astrocyte end foot", "Astrocyte projection", "Atac complex", "Atpase complex", "Atpase dependent transmembrane transport complex", "Autolysosome", "Autophagosome", "Autophagosome membrane", "Axolemma", "Axon", "Axon cytoplasm", "Axon hillock", "Axon initial segment", "Axonal growth cone", "Axonemal microtubule", "Azurophil granule", "Azurophil granule lumen", "Azurophil granule membrane", "B wich complex", "Barr body", "Basal cortex", "Basal dendrite", "Basal part of cell", "Basement membrane", "Basolateral plasma membrane", "Bcl 2 family protein complex", "Beta catenin destruction complex", "Beta catenin tcf complex", "Bleb", "Bloc 1 complex", "Bloc complex", "Blood microparticle", "Borc complex", "Box c d rnp complex", "Box h aca rnp complex", "Box h aca snornp complex", "Box h aca telomerase rnp complex", "Brca1 a complex", "Brca1 c complex", "Brisc complex", "Brush border", "Brush border membrane", "Cajal body", "Calcineurin complex", "Calcium and calmodulin dependent protein kinase complex", "Calcium channel complex", "Calyx of held", "Camp dependent protein kinase complex", "Carboxy terminal domain protein kinase complex", "Caspase complex", "Catalytic complex", "Catalytic step 1 spliceosome", "Catalytic step 2 spliceosome", "Catenin complex", "Cation channel complex", "Cation transporting atpase complex", "Catsper complex", "Caveola", "Ccaat binding factor complex", "Ccr4 not complex", "Ccr4 not core complex", "Cd40 receptor complex", "Cd95 death inducing signaling complex", "Cdc73 paf1 complex", "Cell body", "Cell body membrane", "Cell cell contact zone", "Cell cell junction", "Cell cortex", "Cell cortex region", "Cell division site", "Cell leading edge", "Cell pole", "Cell projection membrane", "Cell substrate junction", "Cell surface", "Cell tip", "Cell trailing edge", "Central element", "Centriolar satellite", "Centriolar subdistal appendage", "Centriole", "Centrosome", "Cerebellar mossy fiber", "Chaperone complex", "Chaperonin containing t complex", "Checkpoint clamp complex", "Chitosome", "Chloride channel complex", "Chromaffin granule", "Chromaffin granule membrane", "Chromatin", "Chromatin silencing complex", "Chromatoid body", "Chromocenter", "Chromosomal region", "Chromosome", "Chromosome centromeric core domain", "Chromosome centromeric region", "Chromosome passenger complex", "Chromosome telomeric region", "Chromosome telomeric repeat region", "Cia complex", "Ciliary basal body", "Ciliary base", "Ciliary membrane", "Ciliary plasm", "Ciliary rootlet", "Ciliary tip", "Ciliary transition fiber", "Ciliary transition zone", "Cilium", "Cis golgi network", "Cis golgi network membrane", "Clathrin adaptor complex", "Clathrin coat", "Clathrin coat of coated pit", "Clathrin coat of endocytic vesicle", "Clathrin coated endocytic vesicle", "Clathrin coated endocytic vesicle membrane", "Clathrin coated pit", "Clathrin coated vesicle", "Clathrin coated vesicle membrane", "Clathrin complex", "Clathrin sculpted gamma aminobutyric acid transport vesicle", "Clathrin sculpted vesicle", "Clathrin vesicle coat", "Cleavage furrow", "Cluster of actin based cell projections", "Coated vesicle", "Coated vesicle membrane", "Cohesin complex", "Collagen containing extracellular matrix", "Collagen trimer", "Commitment complex", "Compact myelin", "Condensed chromosome", "Condensed chromosome centromeric region", "Condensed nuclear chromosome", "Condensin complex", "Contractile fiber", "Contractile ring", "Cop9 signalosome", "Copi coated vesicle", "Copi coated vesicle membrane", "Copi vesicle coat", "Copii coated er to golgi transport vesicle", "Copii vesicle coat", "Core mediator complex", "Cornified envelope", "Cortical actin cytoskeleton", "Cortical cytoskeleton", "Cortical endoplasmic reticulum", "Cortical granule", "Costamere", "Crd mediated mrna stability complex", "Ctf18 rfc like complex", "Cul2 ring ubiquitin ligase complex", "Cul3 ring ubiquitin ligase complex", "Cul4 ring e3 ubiquitin ligase complex", "Cul4a ring e3 ubiquitin ligase complex", "Cul4b ring e3 ubiquitin ligase complex", "Cul5 ring ubiquitin ligase complex", "Cullin ring ubiquitin ligase complex", "Cuticular plate", "Cyclin a2 cdk2 complex", "Cyclin cdk positive transcription elongation factor complex", "Cyclin dependent protein kinase holoenzyme complex", "Cytochrome complex", "Cytolytic granule", "Cytoplasmic dynein complex", "Cytoplasmic exosome rnase complex", "Cytoplasmic microtubule", "Cytoplasmic region", "Cytoplasmic side of endoplasmic reticulum membrane", "Cytoplasmic side of endosome membrane", "Cytoplasmic side of lysosomal membrane", "Cytoplasmic side of membrane", "Cytoplasmic stress granule", "Cytoplasmic ubiquitin ligase complex", "Cytoskeleton of presynaptic active zone", "Cytosolic large ribosomal subunit", "Cytosolic region", "Cytosolic ribosome", "Cytosolic small ribosomal subunit", "Death inducing signaling complex", "Dendrite cytoplasm", "Dendrite membrane", "Dendrite terminus", "Dendritic growth cone", "Dendritic shaft", "Dendritic spine membrane", "Dendritic tree", "Dense body", "Dense core granule", "Dense core granule membrane", "Dentate gyrus mossy fiber", "Derlin 1 retrotranslocation complex", "Desmosome", "Dihydrolipoyl dehydrogenase complex", "Distal axon", "Dna packaging complex", "Dna polymerase complex", "Dna repair complex", "Dna replication factor c complex", "Dna replication preinitiation complex", "Dopaminergic synapse", "Dynactin complex", "Dynein axonemal particle", "Dynein complex", "Dystrophin associated glycoprotein complex", "Early endosome", "Early endosome lumen", "Early endosome membrane", "Early phagosome", "Ekc keops complex", "Elongator holoenzyme complex", "Elongin complex", "Emc complex", "Endocytic vesicle", "Endocytic vesicle lumen", "Endocytic vesicle membrane", "Endolysosome", "Endolysosome lumen", "Endolysosome membrane", "Endopeptidase complex", "Endoplasmic reticulum", "Endoplasmic reticulum chaperone complex", "Endoplasmic reticulum exit site", "Endoplasmic reticulum golgi intermediate compartment", "Endoplasmic reticulum golgi intermediate compartment membrane", "Endoplasmic reticulum lumen", "Endoplasmic reticulum palmitoyltransferase complex", "Endoplasmic reticulum plasma membrane contact site", "Endoplasmic reticulum protein containing complex", "Endoplasmic reticulum quality control compartment", "Endoplasmic reticulum tubular network", "Endoplasmic reticulum tubular network membrane", "Endoribonuclease complex", "Endosome", "Endosome lumen", "Endosome membrane", "Envelope", "Enzyme activator complex", "Epsilon dna polymerase complex", "Equatorial microtubule organizing center", "Er membrane insertion complex", "Er to golgi transport vesicle membrane", "Er ubiquitin ligase complex", "Esc e z complex", "Escrt complex", "Escrt i complex", "Escrt iii complex", "Euchromatin", "Eukaryotic translation initiation factor 2 complex", "Eukaryotic translation initiation factor 2b complex", "Eukaryotic translation initiation factor 3 complex", "Eukaryotic translation initiation factor 3 complex eif3m", "Eukaryotic translation initiation factor 4f complex", "Excitatory synapse", "Exocyst", "Exocytic vesicle", "Exon exon junction complex", "Exoribonuclease complex", "External encapsulating structure", "External side of apical plasma membrane", "External side of plasma membrane", "Extrinsic component of cytoplasmic side of plasma membrane", "Extrinsic component of endoplasmic reticulum membrane", "Extrinsic component of endosome membrane", "Extrinsic component of external side of plasma membrane", "Extrinsic component of membrane", "Extrinsic component of mitochondrial inner membrane", "Extrinsic component of organelle membrane", "Extrinsic component of plasma membrane", "Extrinsic component of postsynaptic membrane", "Extrinsic component of postsynaptic specialization membrane", "Extrinsic component of synaptic membrane", "F actin capping protein complex", "Fascia adherens", "Female germ cell nucleus", "Female pronucleus", "Fibrillar center", "Ficolin 1 rich granule", "Ficolin 1 rich granule lumen", "Ficolin 1 rich granule membrane", "Filamentous actin", "Filopodium", "Filopodium membrane", "Filopodium tip", "Filtration diaphragm", "Flemming body", "Flotillin complex", "Gaba ergic synapse", "Gamma secretase complex", "Gamma tubulin complex", "Gap junction", "Gator2 complex", "Gemini of coiled bodies", "Germ cell nucleus", "Glial cell projection", "Glutamatergic synapse", "Glycinergic synapse", "Glycogen granule", "Glycoprotein complex", "Golgi apparatus", "Golgi apparatus subcompartment", "Golgi associated vesicle", "Golgi associated vesicle membrane", "Golgi cis cisterna", "Golgi cisterna", "Golgi cisterna membrane", "Golgi lumen", "Golgi medial cisterna", "Golgi membrane", "Golgi stack", "Golgi transport complex", "Gpi anchor transamidase complex", "Granular component", "Growth cone membrane", "Gtpase complex", "Guanyl nucleotide exchange factor complex", "H3 histone acetyltransferase complex", "H4 h2a histone acetyltransferase complex", "H4 histone acetyltransferase complex", "Haus complex", "Hemidesmosome", "Hemoglobin complex", "Heterochromatin", "Hfe transferrin receptor complex", "High density lipoprotein particle", "Hippocampal mossy fiber", "Hippocampal mossy fiber to ca3 synapse", "Histone deacetylase complex", "Histone methyltransferase complex", "Histone pre mrna 3 end processing complex", "Hops complex", "Host cellular component", "Hrd1p ubiquitin ligase erad l complex", "Hulc complex", "I band", "Ikappab kinase complex", "Immunological synapse", "Inclusion body", "Inflammasome complex", "Inhibitory synapse", "Inner mitochondrial membrane protein complex", "Ino80 complex", "Ino80 type complex", "Insulin responsive compartment", "Integral component of cytoplasmic side of endoplasmic reticulum membrane", "Integral component of lysosomal membrane", "Integral component of presynaptic active zone membrane", "Integral component of synaptic vesicle membrane", "Integrator complex", "Integrin complex", "Intercalated disc", "Intercellular bridge", "Intercellular canaliculus", "Intermediate filament", "Intermediate filament cytoskeleton", "Intracellular protein containing complex", "Intraciliary transport particle", "Intraciliary transport particle a", "Intraciliary transport particle b", "Intrinsic component of endoplasmic reticulum membrane", "Intrinsic component of golgi membrane", "Intrinsic component of mitochondrial inner membrane", "Intrinsic component of mitochondrial membrane", "Intrinsic component of mitochondrial outer membrane", "Intrinsic component of nuclear inner membrane", "Intrinsic component of organelle membrane", "Intrinsic component of peroxisomal membrane", "Intrinsic component of plasma membrane", "Intrinsic component of postsynaptic density membrane", "Intrinsic component of postsynaptic membrane", "Intrinsic component of postsynaptic specialization membrane", "Intrinsic component of presynaptic active zone membrane", "Intrinsic component of presynaptic membrane", "Intrinsic component of synaptic membrane", "Intrinsic component of synaptic vesicle membrane", "Intrinsic component of vacuolar membrane", "Ion channel complex", "Iron sulfur cluster assembly complex", "Iswi type complex", "Juxtaparanode region of axon", "Keratin filament", "Kinesin complex", "Kinetochore microtubule", "L type voltage gated calcium channel complex", "Lamellar body", "Lamellipodium", "Lamellipodium membrane", "Lamin filament", "Large ribosomal subunit", "Late endosome", "Late endosome membrane", "Lateral element", "Lateral part of cell", "Lateral plasma membrane", "Leading edge membrane", "Lewy body", "Lipid droplet", "Lipopolysaccharide receptor complex", "Lsm1 7 pat1 complex", "Lsm2 8 complex", "Lumenal side of endoplasmic reticulum membrane", "Lumenal side of membrane", "Lysosomal lumen", "M band", "Magnesium dependent protein serine threonine phosphatase complex", "Main axon", "Male germ cell nucleus", "Male pronucleus", "Manchette", "Mcm complex", "Mcrd mediated mrna stability complex", "Mediator complex", "Meiotic cohesin complex", "Meiotic spindle", "Membrane coat", "Membrane microdomain", "Membrane protein complex", "Messenger ribonucleoprotein complex", "Methylosome", "Methyltransferase complex", "Mhc class i peptide loading complex", "Mhc class i protein complex", "Mhc protein complex", "Mib complex", "Micos complex", "Microbody", "Microbody lumen", "Microbody membrane", "Microfibril", "Microtubule", "Microtubule associated complex", "Microtubule bundle", "Microtubule cytoskeleton", "Microtubule end", "Microtubule minus end", "Microtubule organizing center", "Microtubule organizing center attachment site", "Microtubule plus end", "Microvillus", "Microvillus membrane", "Midbody", "Mismatch repair complex", "Mitochondria associated endoplasmic reticulum membrane", "Mitochondrial alpha ketoglutarate dehydrogenase complex", "Mitochondrial crista", "Mitochondrial envelope", "Mitochondrial large ribosomal subunit", "Mitochondrial matrix", "Mitochondrial permeability transition pore complex", "Mitochondrial protein containing complex", "Mitochondrial proton transporting atp synthase complex coupling factor f o", "Mitochondrial pyruvate dehydrogenase complex", "Mitochondrial small ribosomal subunit", "Mitochondrial tricarboxylic acid cycle enzyme complex", "Mitochondrion", "Mitotic cohesin complex", "Mitotic spindle", "Mitotic spindle astral microtubule", "Mitotic spindle microtubule", "Mitotic spindle midzone", "Mitotic spindle pole", "Mll1 2 complex", "Mll3 4 complex", "Mmxd complex", "Motile cilium", "Mpp7 dlg1 lin7 complex", "Mrna cleavage and polyadenylation specificity factor complex", "Mrna cleavage factor complex", "Mrna editing complex", "Multimeric ribonuclease p complex", "Multivesicular body", "Multivesicular body membrane", "Muscle myosin complex", "Myelin sheath", "Myelin sheath abaxonal region", "Myelin sheath adaxonal region", "Myofilament", "Myosin complex", "Myosin filament", "Myosin ii complex", "N terminal protein acetyltransferase complex", "Nadh dehydrogenase complex", "Nascent polypeptide associated complex", "Nata complex", "Nbaf complex", "Neurofibrillary tangle", "Neurofilament", "Neuromuscular junction", "Neuron projection", "Neuron projection cytoplasm", "Neuron projection membrane", "Neuron projection terminus", "Neuron spine", "Neuron to neuron synapse", "Neuronal dense core vesicle", "Neuronal dense core vesicle membrane", "Neuronal ribonucleoprotein granule", "Neurotransmitter receptor complex", "Nlrp3 inflammasome complex", "Nls dependent protein nuclear import complex", "Node of ranvier", "Non motile cilium", "Nonhomologous end joining complex", "Npbaf complex", "Nsl complex", "Nuclear body", "Nuclear chromosome", "Nuclear cyclin dependent protein kinase holoenzyme complex", "Nuclear envelope", "Nuclear envelope lumen", "Nuclear exosome rnase complex", "Nuclear inclusion body", "Nuclear inner membrane", "Nuclear lamina", "Nuclear membrane", "Nuclear outer membrane", "Nuclear outer membrane endoplasmic reticulum membrane network", "Nuclear periphery", "Nuclear pore", "Nuclear pore central transport channel", "Nuclear pore nuclear basket", "Nuclear pore outer ring", "Nuclear protein containing complex", "Nuclear replication fork", "Nuclear rna export factor complex", "Nuclear speck", "Nuclear stress granule", "Nuclear ubiquitin ligase complex", "Nucleocytoplasmic transport complex", "Nucleoid", "Nucleolar ribonuclease p complex", "Nucleolus", "Nucleotide activated protein kinase complex", "Nucleotide excision repair complex", "Nurd complex", "Nurf complex", "Oligosaccharyltransferase complex", "Organellar ribosome", "Organelle envelope lumen", "Organelle inner membrane", "Organelle membrane contact site", "Organelle subcompartment", "Origin recognition complex", "Outer dense fiber", "Outer kinetochore", "Outer membrane", "Outer mitochondrial membrane protein complex", "Oxidoreductase complex", "Oxoglutarate dehydrogenase complex", "P body", "Palmitoyltransferase complex", "Pam complex tim23 associated import motor", "Paranodal junction", "Paranode region of axon", "Paraspeckles", "Pcg protein complex", "Peptidase complex", "Peptidase inhibitor complex", "Pericentric heterochromatin", "Pericentriolar material", "Perikaryon", "Perinuclear endoplasmic reticulum", "Perinuclear region of cytoplasm", "Perinucleolar compartment", "Phagocytic cup", "Phagocytic vesicle", "Phagocytic vesicle lumen", "Phagocytic vesicle membrane", "Phagolysosome", "Phagophore assembly site", "Phagophore assembly site membrane", "Phosphatase complex", "Phosphatidylinositol 3 kinase complex", "Phosphatidylinositol 3 kinase complex class iii", "Phospholipid translocating atpase complex", "Photoreceptor connecting cilium", "Photoreceptor inner segment", "Photoreceptor outer segment", "Photoreceptor ribbon synapse", "Picln sm protein complex", "Pigment granule", "Pinosome", "Plasma membrane protein complex", "Plasma membrane raft", "Plasma membrane region", "Plasma membrane signaling receptor complex", "Platelet alpha granule", "Platelet alpha granule lumen", "Platelet alpha granule membrane", "Platelet dense granule", "Platelet dense granule lumen", "Platelet dense tubular network", "Platelet dense tubular network membrane", "Pml body", "Podosome", "Polar microtubule", "Pole plasm", "Polymeric cytoskeletal fiber", "Polysomal ribosome", "Polysome", "Pore complex", "Post mrna release spliceosomal complex", "Postsynapse", "Postsynaptic cytosol", "Postsynaptic density intracellular component", "Postsynaptic density membrane", "Postsynaptic endocytic zone", "Postsynaptic endosome", "Postsynaptic membrane", "Postsynaptic recycling endosome", "Postsynaptic specialization intracellular component", "Postsynaptic specialization membrane", "Prc1 complex", "Pre snornp complex", "Precatalytic spliceosome", "Prefoldin complex", "Preribosome", "Preribosome large subunit precursor", "Preribosome small subunit precursor", "Prespliceosome", "Presynapse", "Presynaptic active zone", "Presynaptic active zone cytoplasmic component", "Presynaptic active zone membrane", "Presynaptic cytoskeleton", "Presynaptic cytosol", "Presynaptic endocytic zone", "Presynaptic membrane", "Pronucleus", "Protease inhibitor complex", "Proteasome accessory complex", "Proteasome complex", "Proteasome core complex", "Proteasome core complex alpha subunit complex", "Proteasome core complex beta subunit complex", "Proteasome regulatory particle", "Proteasome regulatory particle base subcomplex", "Proteasome regulatory particle lid subcomplex", "Protein acetyltransferase complex", "Protein complex involved in cell adhesion", "Protein dna complex", "Protein kinase complex", "Protein lipid complex", "Protein phosphatase 4 complex", "Protein phosphatase type 1 complex", "Protein phosphatase type 2a complex", "Proton transporting atp synthase complex", "Proton transporting atp synthase complex catalytic core f 1", "Proton transporting atp synthase complex coupling factor f o", "Proton transporting two sector atpase complex", "Proton transporting two sector atpase complex catalytic domain", "Proton transporting two sector atpase complex proton transporting domain", "Proton transporting v type atpase complex", "Proton transporting v type atpase v0 domain", "Proton transporting v type atpase v1 domain", "Proximal dendrite", "Prp19 complex", "Pseudopodium", "Ptw pp1 phosphatase complex", "Pwp2p containing subcomplex of 90s preribosome", "R2tp complex", "Ragulator complex", "Rdna heterochromatin", "Receptor complex", "Recycling endosome", "Recycling endosome membrane", "Replication fork", "Replisome", "Respirasome", "Respiratory chain complex iii", "Respiratory chain complex iv", "Retromer complex", "Ribbon synapse", "Ribonuclease mrp complex", "Ribonuclease p complex", "Ribonucleoprotein complex", "Ribonucleoprotein granule", "Ribose phosphate diphosphokinase complex", "Ribosomal subunit", "Ribosome", "Ripoptosome", "Risc loading complex", "Rna cap binding complex", "Rna polymerase complex", "Rna polymerase i complex", "Rna polymerase ii core complex", "Rna polymerase ii holoenzyme", "Rna polymerase ii transcription regulator complex", "Rna polymerase ii transcription repressor complex", "Rna polymerase iii complex", "Rna polymerase iii transcription regulator complex", "Rnai effector complex", "Rough endoplasmic reticulum", "Rough endoplasmic reticulum membrane", "Rpap3 r2tp prefoldin like complex", "Ruffle", "Ruffle membrane", "Saga complex", "Saga type complex", "Sarcolemma", "Sarcoplasm", "Sarcoplasmic reticulum lumen", "Sarcoplasmic reticulum membrane", "Scar complex", "Scf ubiquitin ligase complex", "Schaffer collateral ca1 synapse", "Schmidt lanterman incisure", "Sec61 translocon complex", "Secondary lysosome", "Secretory granule", "Secretory granule membrane", "Secretory vesicle", "Seh1 associated complex", "Septin cytoskeleton", "Serine protease inhibitor complex", "Set1c compass complex", "Sex chromatin", "Sex chromosome", "Shelterin complex", "Side of membrane", "Signal peptidase complex", "Signal recognition particle", "Sin3 complex", "Sin3 type complex", "Site of dna damage", "Site of double strand break", "Site of polarized growth", "Sm like protein family complex", "Smad protein complex", "Small ribosomal subunit", "Small subunit processome", "Smc5 smc6 complex", "Smn complex", "Smn sm protein complex", "Smooth endoplasmic reticulum", "Smooth endoplasmic reticulum membrane", "Snare complex", "Sno s rna containing ribonucleoprotein complex", "Sodium potassium exchanging atpase complex", "Somatodendritic compartment", "Sorting endosome", "Spanning component of membrane", "Specific granule", "Specific granule lumen", "Specific granule membrane", "Spectrin", "Spectrin associated cytoskeleton", "Sperm annulus", "Sperm connecting piece", "Sperm fibrous sheath", "Sperm head", "Sperm head plasma membrane", "Sperm midpiece", "Sperm plasma membrane", "Sperm principal piece", "Spermatoproteasome complex", "Spindle", "Spindle microtubule", "Spindle midzone", "Spindle pole", "Spindle pole centrosome", "Spliceosomal complex", "Spliceosomal snrnp complex", "Spliceosomal tri snrnp complex", "Stereocilium bundle", "Stereocilium membrane", "Stereocilium tip", "Striated muscle thin filament", "Sumo ligase complex", "Supramolecular complex", "Supramolecular polymer", "Swi snf complex", "Swr1 complex", "Synapse", "Synaptic membrane", "Synaptic vesicle membrane", "Synaptonemal structure", "T tubule", "Telomerase holoenzyme complex", "Terminal bouton", "Tertiary granule", "Tertiary granule lumen", "Tertiary granule membrane", "Tetraspanin enriched microdomain", "Tho complex", "Tight junction", "Tim22 mitochondrial import inner membrane insertion complex", "Tim23 mitochondrial import inner membrane translocase complex", "Tor complex", "Torc1 complex", "Trans golgi network", "Trans golgi network membrane", "Trans golgi network transport vesicle", "Trans golgi network transport vesicle membrane", "Transcription elongation factor complex", "Transcription export complex", "Transcription export complex 2", "Transcription factor tfiid complex", "Transcription factor tfiih holo complex", "Transcription factor tfiiic complex", "Transcription factor tftc complex", "Transcription preinitiation complex", "Transcription regulator complex", "Transcription repressor complex", "Transferase complex", "Transferase complex transferring phosphorus containing groups", "Translation preinitiation complex", "Translocon complex", "Transport vesicle", "Transport vesicle membrane", "Transporter complex", "Trapp complex", "Tricarboxylic acid cycle enzyme complex", "Triglyceride rich plasma lipoprotein particle", "Trna methyltransferase complex", "Trna splicing ligase complex", "Tubular endosome", "U1 snrnp", "U12 type spliceosomal complex", "U2 snrnp", "U2 type catalytic step 2 spliceosome", "U2 type spliceosomal complex", "U2af complex", "U4 snrnp", "U5 snrnp", "U6 snrnp", "U7 snrnp", "Ubiquitin conjugating enzyme complex", "Ubiquitin ligase complex", "Unconventional myosin complex", "Uniplex complex", "Vacuolar lumen", "Vacuolar membrane", "Vacuolar proton transporting v type atpase v0 domain", "Vacuole", "Varicosity", "Vcp npl4 ufd1 aaa atpase complex", "Vesicle coat", "Vesicle lumen", "Vesicle membrane", "Vesicle tethering complex", "Voltage gated calcium channel complex", "Wash complex", "Weibel palade body", "Wnt signalosome", "X chromosome", "Xy body", "Zona pellucida receptor complex", "Zonula adherens", "Zymogen granule", "Zymogen granule membrane"], "available_proteins": ["AAAS", "AAMP", "AAR2", "AARS", "AARS2", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABRAXAS2", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADNP", "ADPGK", "ADRM1", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AGTRAP", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK6", "AKAP1", "AKAP12", "AKAP8", "AKAP8L", "AKR1A1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "ALG5", "ALKBH5", "ALYREF", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOBEC3C", "APOL2", "APOOL", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARHGEF7", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6", "ARL6IP1", "ARL6IP5", "ARL8A", "ARMCX3", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ASAH1", "ASCC1", "ASCC3", "ASNA1", "ASPH", "ASPSCR1", "ATAD1", "ATAD3A", "ATAD3B", "ATAD5", "ATG9A", "ATP11C", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "B3GALT6", "B4GAT1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS2", "BCCIP", "BCL2L13", "BCLAF1", "BCOR", "BCS1L", "BDH2", "BICD2", "BIRC6", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPTF", "BRD1", "BRD2", "BRI3BP", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "C12orf43", "C19orf70", "C1QBP", "C1orf35", "C2orf49", "CAB39", "CACNA2D1", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CAST", "CBFB", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC137", "CCDC22", "CCDC47", "CCDC58", "CCDC8", "CCDC86", "CCDC93", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA2", "CDH2", "CDIPT", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CENPF", "CENPI", "CEP170", "CEP44", "CEP55", "CEPT1", "CERS2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD4", "CHD7", "CHEK2", "CHERP", "CHID1", "CHMP2A", "CHMP2B", "CHMP4B", "CHMP5", "CHMP6", "CHMP7", "CHORDC1", "CHTF18", "CHTOP", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP2L", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLTA", "CLTB", "CLTC", "CMPK1", "CNN2", "CNN3", "CNNM4", "CNOT1", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG2", "COG4", "COG7", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7B", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF7", "CPT2", "CRKL", "CRNKL1", "CRTAP", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC15", "CWC22", "CWF19L1", "CXorf57", "CYB5B", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCXR", "DDA1", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS13", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX35", "DHX36", "DHX37", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIDO1", "DIEXF", "DIMT1", "DIP2B", "DIS3", "DKC1", "DLAT", "DLD", "DLGAP5", "DLST", "DNAAF5", "DNAJA1", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNTTIP2", "DOCK1", "DOCK7", "DPM1", "DPYSL2", "DR1", "DRG1", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "DYNLL2", "DYNLT1", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "EDC4", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5A", "ELAC2", "ELAVL1", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENO1", "ENO2", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERCC6L", "ERG28", "ERGIC1", "ERGIC2", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESS2", "ESYT1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC5", "EXOC6", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FAF1", "FAF2", "FAHD1", "FAM162A", "FAM208A", "FAM49B", "FAM8A1", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD5", "FBL", "FBXO7", "FCGRT", "FDFT1", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP10", "FKBP1A", "FKBP2", "FKBP4", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNDC3A", "FNTA", "FNTB", "FOXRED1", "FRG1", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FXR1", "FXR2", "FYTTD1", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDAP2", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GGA2", "GGCX", "GGH", "GHDC", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLB1L2", "GLDC", "GLG1", "GLMN", "GLOD4", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GNA13", "GNAI2", "GNAI3", "GNG5", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNS", "GOLGB1", "GOLIM4", "GOLM1", "GORASP2", "GOT2", "GPAA1", "GPATCH4", "GPD1L", "GPD2", "GPHN", "GPI", "GPR107", "GPR108", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSR", "GSTK1", "GSTM2", "GSTM3", "GTF2F1", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS5", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDHD5", "HDLBP", "HEATR1", "HEBP2", "HELLS", "HELZ", "HEXA", "HEXB", "HEXIM1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMCES", "HMGA1", "HMGA2", "HMGB1", "HMGB2", "HMGB3", "HMGCR", "HMGN2", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HP1BP3", "HPF1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPB11", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICE1", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFIT5", "IFNGR1", "IFT27", "IGF1R", "IGF2BP1", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INCENP", "INTS1", "INTS13", "INTS14", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQSEC1", "ISOC1", "IST1", "ITCH", "ITGB1", "ITM2B", "ITPK1", "IVD", "JAGN1", "JMJD6", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KIAA0319L", "KIAA0368", "KIF11", "KIF14", "KIF18A", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "LAMP1", "LAMTOR1", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIG3", "LIMA1", "LIN28B", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC59", "LRWD1", "LSM14A", "LSM2", "LSM4", "LSM6", "LSM7", "LSM8", "LSS", "LTA4H", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAK16", "MANBA", "MANF", "MAP1B", "MAP2K1", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKS", "MARS", "MAT2A", "MAT2B", "MATR3", "MAU2", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDC1", "MDH1", "MDH2", "MDN1", "ME2", "MECP2", "MED24", "MED4", "METTL13", "MFAP1", "MFF", "MFN1", "MFN2", "MFSD10", "MFSD8", "MGAT1", "MGME1", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MIPEP", "MKI67", "MLEC", "MMADHC", "MMS19", "MOB4", "MOGS", "MORC2", "MORF4L1", "MORF4L2", "MOV10", "MPDU1", "MPG", "MPHOSPH10", "MPHOSPH8", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL45", "MRPL47", "MRPL51", "MRPL53", "MRPL9", "MRPS11", "MRPS15", "MRPS17", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTPN", "MTX1", "MTX2", "MTX3", "MUT", "MXRA7", "MYADM", "MYBBP1A", "MYCBP", "MYCBP2", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH9", "MYL6", "MYL6B", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NAGLU", "NAMPT", "NAP1L1", "NAP1L4", "NAPA", "NASP", "NAT10", "NAXE", "NBAS", "NCAPD2", "NCAPD3", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "ND1", "NDC1", "NDUFA10", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV2", "NECAP2", "NEDD4L", "NEFM", "NEK9", "NELFB", "NELFCD", "NELFE", "NENF", "NF1", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIPSNAP2", "NIT2", "NKRF", "NLE1", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NPC1", "NPC2", "NPLOC4", "NPM1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NUB1", "NUCB1", "NUCB2", "NUDC", "NUDT1", "NUDT12", "NUDT21", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUTF2", "NVL", "NXF1", "OAT", "OCIAD1", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OXA1L", "OXCT1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAIP1", "PAK1IP1", "PAK2", "PALLD", "PARK7", "PARN", "PARP1", "PAWR", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDZD11", "PECR", "PEF1", "PELP1", "PES1", "PEX14", "PEX19", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGK1", "PGM1", "PGM2", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHF6", "PHIP", "PI4K2A", "PI4KA", "PIBF1", "PICALM", "PIGK", "PIGS", "PIGT", "PIK3C2A", "PIK3R4", "PIN4", "PITPNB", "PITRM1", "PKM", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLRG1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "PON2", "POP1", "POP7", "POR", "PPA2", "PPAN", "PPIB", "PPID", "PPIF", "PPIH", "PPIL1", "PPM1F", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4R3A", "PPP5C", "PPP6C", "PPT1", "PPT2", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREPL", "PRIM1", "PRIM2", "PRKAA1", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRMT1", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38A", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2C", "PRSS3", "PSAP", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSPC1", "PTBP1", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTK7", "PTPA", "PTPN1", "PTPRF", "PTRH2", "PUM1", "PUM3", "PURA", "PWP1", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "PYM1", "QARS", "QKI", "QPRT", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB23", "RAB2A", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "REEP5", "REPS1", "RER1", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RIPK1", "RMDN1", "RNASEH2A", "RNASEH2B", "RNASET2", "RNF14", "RNF2", "RNF20", "RNF219", "RNF40", "RNMT", "RNPS1", "ROCK1", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RSU1", "RTCB", "RTFDC1", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SAMD4B", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCRIB", "SCRN1", "SCYL2", "SDAD1", "SDE2", "SDHA", "SDHB", "SEC11A", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SELENBP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHMT2", "SHTN1", "SIGMAR1", "SIL1", "SIN3A", "SIRT1", "SIRT2", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC2A1", "SLC30A7", "SLC35A4", "SLC35B2", "SLC38A1", "SLC3A2", "SLC7A1", "SLC7A5", "SLC9A3R1", "SLC9A6", "SLFN11", "SLIRP", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SORT1", "SPAG5", "SPAG9", "SPART", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPECC1", "SPECC1L", "SPEN", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRFBP1", "SRI", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STIP1", "STMN1", "STOML2", "STRAP", "STRBP", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SV2A", "SWAP70", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TAB1", "TACC3", "TAF15", "TAF2", "TAF5", "TAF6L", "TAMM41", "TAOK1", "TARDBP", "TARS2", "TBCA", "TBCB", "TBCD", "TBCE", "TBL2", "TBL3", "TBRG4", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TECR", "TELO2", "TERF2IP", "TES", "TEX10", "TFAM", "TFB1M", "TFG", "TFIP11", "TFRC", "TGOLN2", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "TIA1", "TIAL1", "TIGAR", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TJP1", "TKT", "TLN1", "TM9SF2", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM115", "TMEM126A", "TMEM14C", "TMEM167A", "TMEM192", "TMEM199", "TMEM201", "TMEM214", "TMEM230", "TMEM259", "TMEM33", "TMEM43", "TMEM65", "TMEM97", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TMX4", "TNPO1", "TNPO3", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1AIP2", "TOX4", "TP53", "TP53BP1", "TP53BP2", "TPD52", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPRKB", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC4", "TRAPPC5", "TRAPPC8", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMT112", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSNAX", "TSPAN6", "TSPO", "TSPYL1", "TSR1", "TST", "TTC1", "TTC19", "TTC21B", "TTC26", "TTC37", "TTLL12", "TTLL4", "TTYH3", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWNK", "TXLNG", "TXNDC12", "TXNDC5", "TXNDC9", "TXNL1", "TXNL4A", "TXNRD1", "TXNRD2", "TYMS", "U2AF2", "UBA1", "UBA2", "UBAP2L", "UBE2K", "UBE2L3", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBLCP1", "UBQLN4", "UBR1", "UBR4", "UBR5", "UBTF", "UBXN4", "UCHL5", "UFD1", "UFL1", "UFM1", "UGGT1", "UHRF1", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "URB2", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP19", "USP28", "USP33", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VMP1", "VPS16", "VPS25", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4A", "VPS4B", "VPS50", "VRK1", "VRK3", "VTA1", "VWA8", "WAPL", "WARS2", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR43", "WDR46", "WDR5", "WDR61", "WDR70", "WDR75", "WDR77", "WDR82", "WFS1", "WIZ", "WTAP", "XAB2", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS2", "YIF1A", "YIPF5", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBTB10", "ZC3H14", "ZC3H18", "ZC3HC1", "ZCRB1", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYND8", "ZNF207", "ZNF326", "ZNF638", "ZPR1", "ZW10", "ZYX"], "leading_proteins": ["AAMP", "ABCB1", "ACP2", "ACTN1", "AGL", "AGPAT1", "AGTRAP", "AHCTF1", "AHCYL1", "AIFM1", "AIP", "AKAP8", "AKAP8L", "AKT2", "ALDH3A2", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANKRD17", "ANP32A", "ANXA1", "ANXA11", "ANXA7", "AP3M1", "AP3S1", "APLP2", "APMAP", "APOBEC3C", "APOL2", "APPL1", "ARFGAP2", "ARL2", "ASPH", "ATP13A1", "ATP2B1", "ATP5L", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1C1", "ATP6V1E1", "AUP1", "B4GAT1", "BABAM2", "BAG6", "BAIAP2", "BCLAF1", "BICD2", "BSG", "BUB1B", "C1QBP", "CACYBP", "CALU", "CASK", "CBX1", "CCDC134", "CDC16", "CDC23", "CDK12", "CDK4", "CENPF", "CENPI", "CEP55", "CERS2", "CHMP2A", "CIRBP", "CLCN3", "CLN5", "CNNM4", "COA3", "COA7", "COLEC12", "COMT", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "CPNE1", "CPOX", "CRKL", "CRNKL1", "CRTAP", "CSNK1A1", "CTBP1", "CTNNBL1", "CTR9", "CTSA", "CTSB", "CTTN", "CWC15", "CYB5B", "CYFIP1", "CYP51A1", "DCAF13", "DCPS", "DCTN2", "DCTN3", "DCUN1D1", "DDB1", "DDX21", "DDX56", "DEK", "DHCR24", "DHX33", "DIABLO", "DIS3", "DNAJB11", "DNAJC2", "DYNLL1", "ECE1", "EHD4", "ELOC", "ELP2", "EMD", "EPHX1", "EPPK1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERG28", "ERGIC2", "ERGIC3", "EWSR1", "EXOC5", "EXOC7", "EXOSC6", "EXOSC8", "F11R", "FAM162A", "FAM49B", "FBXO7", "FCGRT", "FDFT1", "FGFR1OP", "FKBP10", "FKBP1A", "FMR1", "FOXRED1", "FUCA1", "FUCA2", "FXR1", "FXR2", "GAA", "GAK", "GALNT1", "GALNT7", "GAR1", "GBA", "GDAP2", "GGH", "GLA", "GLB1", "GLB1L2", "GLDC", "GLG1", "GLMN", "GLRX3", "GLRX5", "GM2A", "GOLGB1", "GOLIM4", "GOLM1", "GPAA1", "GPHN", "GPR107", "GPR108", "GRB2", "GSTM3", "GUSB", "GYS1", "HAUS5", "HDAC2", "HELZ", "HEXA", "HGS", "HLA-A", "HLA-B", "HLA-C", "HM13", "HMOX1", "HMOX2", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPD", "HNRNPH2", "HNRNPK", 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3.36301188653944 3.2424277527979313 1.935823411407979 0.3010513017078077 0.0894822833221592 0.0496758524768897 6.843379440375148e-05 1.2254814710404596e-06 1.704552757461398e-06 +Steroid binding 9 22 3.3735687300134045 0.0007420052007964 8.424757281553399 21.398058252427184 1.4469817519716153 0.1523451695819165 3.035656818503787 2.066091501771892 1.85140774519605 0.2395996334984524 0.0003419436993158 0.0017444833819082 3.769541984501074e-07 0.0001580597168237 1.7163900968398735e-05 +Phospholipid binding 21 76 3.3301374922640803 0.0008680310999114 18.890776699029125 88.4635922330097 0.777309720287493 0.452120200534915 6.970479526806733 10.51702894240924 1.1988133109990275 0.3785217149858343 0.0560713970048401 0.0599945491514207 0.0084671328775968 0.0313443852181343 0.0373316399383006 +Lipid binding 35 125 3.2982081935737537 0.000973039588078 30.883495145631063 138.65533980582524 0.9844637598707308 0.4289871747751645 8.92748670410201 14.760635317682617 1.446857667744565 0.4068298387995807 0.0114557350692838 0.0217449865087235 0.0003462915456642 0.0060508412169139 0.0010897343598396 +Hydrolase activity hydrolyzing o glycosyl compounds 13 18 3.2441094996776463 0.0011781844408365 8.830097087378642 20.84223300970874 0.5983257656540719 0.2104301479001341 3.2223833352824554 2.4557961681485057 1.9540573665272416 0.2728112677124137 0.2821140734943566 0.2106238865633207 9.137815410524424e-05 1.627158857801424e-07 3.537388223106496e-08 +Endopeptidase activity 21 59 3.2017643315502524 0.0013658869397921 19.08495145631068 62.800970873786405 1.5604938505680932 0.2935756148549138 5.629332570724372 6.156865220927466 1.27979578418692 0.359984229645684 0.0055601726728426 0.0476013329010025 0.0052178109018932 4.729106520853326e-05 3.97539622972945e-07 +Exopeptidase activity 12 29 3.12853827963738 0.0017567812601411 9.74514563106796 31.84223300970874 1.193034763402526 0.2308543476384821 3.0338864063053523 1.9513159274241312 1.6646797512653713 0.2911825093455628 5.827121783820316e-05 0.0032700867405931 2.4490692503129386e-05 0.0006279861154086 5.478593541938059e-06 +Protein transporter activity 4 14 3.0224955223110963 0.0025069979172607 6.053398058252427 14.696601941747574 1.6882240898296943 0.1359359142649309 2.957968193176 1.443999336657768 1.4805047019217734 0.2345897542974644 0.0006396322141498 0.0002365528693072 0.0016986126979642 0.0002808583984775 0.0062616815035888 +Sterol binding 6 17 2.8576635926005647 0.0042677258064574 5.495145631067961 16.27912621359223 1.1610523788441311 0.1592175050218891 2.159304933149918 1.9111962434971217 1.7231989277496158 0.231586711794193 0.0018812928974134 0.0007069993740851 2.2037872854000083e-05 0.0016056440309417 0.0002645246913318 +Protein transmembrane transporter activity 2 11 2.7569332034990066 0.0058346269073101 4.37621359223301 11.264563106796116 1.6409152716253632 0.1284874270119089 2.3258190399954897 0.995332092405782 1.387057072324357 0.2266762256512647 0.0001967001664997 7.189730386960826e-05 0.0005309775927247 0.0006143549700213 0.0078812527225172 +Cholesterol binding 6 14 2.7474324685053806 0.0060063876770062 5.25 13.29126213592233 1.1679703080780182 0.1357521674166823 1.9454015982929531 1.7674569958716484 1.7544522374432017 0.2116991383290636 0.0011017003564739 0.0004104233816526 8.719376349895246e-06 0.0006827439557333 6.616615234342882e-05 +Macromolecule transmembrane transporter activity 2 12 2.7041951950026872 0.0068470054819518 4.820388349514563 12.281553398058252 1.6605285757306012 0.1306403746261988 2.4754663863133306 1.0160601209961664 1.3599823000893485 0.2280235038874096 0.0003249275046487 0.0001192904084611 0.0008717411361388 0.0011814468070448 0.00223229240551 +Alcohol binding 7 17 2.6902986452671094 0.0071388101205611 5.70873786407767 16.094660194174757 1.0972550148478282 0.1642412137618775 2.3364194162363723 2.1334758164294443 1.72577974721897 0.2306417307890987 0.0048225524960927 0.0018494623097264 0.0001113664394611 0.0068683859678987 0.0005879318152671 +Threonine type peptidase activity 6 8 2.6144405821107077 0.0089373704314283 3.8106796116504857 8.762135922330097 1.392634148189787 0.2146040118876429 1.6274593113109357 0.6695334565847216 1.0340073360925757 0.2572219198248905 0.0001068602999376 0.0020655426456597 0.0002902447274798 4.739959742822594e-07 1.5533184688236115e-06 +Threonine type endopeptidase activity 6 8 2.6144405821107077 0.0089373704314283 3.7135922330097086 7.970873786407767 1.4913184573846054 0.1902243906475925 1.515457478026574 0.1681602725795027 1.0170822776023185 0.2455850375425174 3.5930470170495774e-05 0.0010343090391069 9.839858993160587e-05 3.59582749836129e-08 6.442496475603332e-08 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 8 24 2.6058373404355213 0.0091649974089254 9.395631067961164 29.8373786407767 1.5709767518568172 0.2393367467664754 3.119976403291062 3.762391942431812 1.2135099906711824 0.3124947384976632 0.1337325165619652 0.3682511930157578 0.0122106671185157 0.0071204993039649 0.0144813562422372 +Nuclear localization sequence binding 4 14 2.5365972828691423 0.0111935637465665 4.655339805825243 14.580097087378642 -0.2713323353987631 0.6234341357535338 2.815981718667898 1.2774717105112603 0.7044423864937683 0.2841697148619335 0.0004346393163843 0.0001600370606554 0.0011613234829685 0.0017174581383874 0.0034992238505004 +Ion transmembrane transporter activity 15 91 2.534583103891485 0.011258121981704 37.34466019417476 101.497572815534 2.0154097423383375 0.2561362875319209 17.172953606300336 11.579295798802024 2.277787478419462 0.3756175790939143 0.0052222049518044 0.0038785197399043 0.00983012928708 0.0034448232633538 0.1185577774973063 +Molecular transducer activity 15 31 2.4557525195865884 0.0140589939438717 10.91747572815534 33.40533980582524 1.343848990749489 0.2329582295822712 4.7124072380860955 5.830391636254363 1.6098335072319665 0.2956883791113679 0.2606604783115365 0.3622182117869869 0.1025723617341366 0.5944333056930783 0.4860925960432058 +Nuclear import signal receptor activity 4 12 2.394655491065871 0.0166359880317648 4.580097087378641 12.1747572815534 0.1497034884548014 0.5811134195329518 2.7696153022780754 1.385971212985204 0.911475715951457 0.3192399143946276 0.0002348807111153 8.597904339497348e-05 0.0006327439593496 0.0007750266814789 0.0013369974246366 +Serine type exopeptidase activity 4 7 2.3596053115864897 0.0182943874720611 3.783980582524272 6.997572815533981 1.020609253431403 0.1137432544246352 1.3363606860118669 0.0492066381861973 1.87035730934538 0.1990592265121372 2.527574560795007e-05 0.0008300469730069 6.936272072908627e-05 3.788095303003865e-05 2.8311070051942505e-05 +Anion channel activity 2 8 2.3412701769128708 0.0192182540392618 4.20873786407767 11.21116504854369 1.03959259790327 0.2192420598609839 2.3076742714116403 2.0905640066649145 1.3937691950814175 0.2662450395835827 0.0156532449699884 0.0082126449787597 0.0293903981750984 0.0291459656321865 0.1526461610854137 +Tetrapyrrole binding 6 14 2.3388889484791195 0.0193411816076614 7.402912621359223 16.83252427184466 2.0044897428967667 0.1259264696495541 2.9589081005845346 2.0417036568087963 1.3464702305086589 0.2177422235164347 0.0059850441464068 0.2336798458054532 0.0001612622666265 0.0002941476334404 0.0042301612836837 +Amide binding 33 99 2.336406619840803 0.0194700592670977 22.521844660194176 102.53398058252426 0.8716704131409604 0.4134472412494542 7.596116055031058 7.786365397071367 1.2519470693533183 0.3815633057547212 7.812898722926956e-05 6.2788056077878775e-06 0.0001566716265794 1.1426637121287249e-07 2.613071838136866e-10 +Signal sequence binding 6 24 2.3352810984267185 0.0195287409306181 5.560679611650485 26.50242718446602 0.435828138514089 0.5798441286349703 3.257360227950366 2.1761045475756564 0.8353222176818301 0.3288364338889158 0.0025527432728967 0.0009649225463882 0.0065760397653667 0.0025916473916576 0.0028137185393519 +Exogenous protein binding 3 13 2.2916438671536943 0.0219262019684329 4.509708737864078 15.157766990291265 0.7214109752050332 0.2527966464979699 2.499010078306418 1.9009100692398744 1.5211756979359785 0.2791170769282048 0.2670540153627264 0.1988423464133734 0.0091243340822671 0.0940672040532474 0.0655768501043339 +Ubiquitin binding 10 26 2.291502849069094 0.0219343472805777 8.74757281553398 29.194174757281555 -0.2394500404433165 0.5969657249917615 4.006592738339085 4.26331894146384 0.8579159018639084 0.311349671576461 1.0 1.0 1.0 0.1867445382627056 0.1651368225347115 +Mrna 3 utr binding 19 49 2.25738960413664 0.0239837407406833 16.033980582524272 48.59708737864078 0.0362832452197449 0.6336882607045261 7.2120321981260895 2.351985581765116 0.901256036485658 0.3251065802566649 0.1000804307877045 1.0 0.0390282143216565 0.0026901941541905 1.4066399153520236e-07 +Glycolipid binding 2 8 2.214772382707854 0.0267756917362522 3.95873786407767 9.17233009708738 1.1300394975336625 0.1723818604496332 1.779261971800237 1.789101691327159 1.517965150696512 0.2390589148665743 0.1105991351345201 1.0 0.1515272625734178 0.0073447144383531 0.0465653262864464 +Mirna binding 7 13 2.196587185190903 0.0280499422686757 5.356796116504855 13.716019417475728 0.2051470497500039 0.5875839080603199 2.9289942319606412 1.5748125731018472 0.8441668576388831 0.3077891504368221 1.0 1.0 1.0 0.0379489226270714 0.0005790030159305 +Phospholipase activity 4 13 2.195226315797908 0.0281473674534589 3.1990291262135924 15.094660194174756 -0.306546996035562 0.2833880814714293 1.8628194074527815 2.042811367353886 1.4121024393654518 0.2371187700906001 0.2821140734943566 1.0 0.0011293669878184 0.0057706709278987 0.0818539267356338 +Lipase activity 4 13 2.195226315797908 0.0281473674534589 4.160194174757281 17.95145631067961 -0.3883889220249866 0.2447386375427953 2.2541370727794456 2.684470408535888 1.602380040893784 0.2433104127648577 0.3347698423652137 1.0 0.0024373211620913 0.0136344588869589 0.1573271124776855 +Peptide antigen binding 5 6 2.180630223389476 0.0292107778056684 2.25 5.218446601941747 1.3488418251083294 0.2076946662826 1.4985834735457568 1.269832767279765 0.9581301458127084 0.2397273125927817 0.098240976313303 0.0711332726649859 0.1349531130589082 0.000366006536683 4.367834065541858e-05 +O acyltransferase activity 4 9 2.163900377555038 0.0304719959641641 4.711165048543689 12.395631067961164 0.9877600518928406 0.2684789023147002 2.6842893514436073 2.3496085895491885 1.2379749168209273 0.2720543739153138 1.0 1.0 0.266209970857853 0.5428479192551358 0.0179733508374719 +Phosphatidylcholine binding 2 7 2.1634749580193677 0.0305046677647362 2.2524271844660193 7.929611650485437 1.2697801287388335 0.1567893034984199 1.081337239384838 1.04388968498945 1.4953842980517238 0.2256102823610289 0.0052396036731361 0.0027067874988798 0.000440337804097 0.0061570039439817 0.0397387250697101 +Symporter activity 1 6 2.1582786980261397 0.0309061699019166 3.638349514563106 9.1747572815534 0.9770544165414302 0.3122690599192905 2.3735568316725377 2.065327188945721 1.1044541290009051 0.3081067804681572 0.0365215616422684 0.0195557545343205 0.0666692325567911 0.2871762535363917 0.637323462105345 +Amyloid beta binding 8 11 2.1498228295863653 0.0315692316460201 3.5898058252427183 10.560679611650484 1.053866189591651 0.2544642672774957 2.009490338022764 1.9342863324228672 1.0942484681219342 0.2534200432416059 0.2253545302279321 0.1665759675679584 0.3009165941166509 0.224257489169728 0.0319540971359957 +Quaternary ammonium group binding 2 11 2.148156651812005 0.0317013130114416 2.8567961165048543 12.12864077669903 0.9707568143407772 0.2573327609820879 1.4849985868988949 1.260087490061347 1.304146106648176 0.2795917987269193 0.0098222160934675 0.0051137089586154 0.0011613234829685 0.0152248647419399 0.088385561156941 +Ubiquitin like protein binding 11 30 2.145084043629512 0.0319461279711648 10.031553398058252 34.57281553398058 -0.2315387253410404 0.6088049339292193 4.630678043262404 4.804633568052182 0.8321700861078453 0.310406239658787 1.0 1.0 1.0 0.2797813766918144 0.1710514293041205 +Sterol transporter activity 3 9 2.1439215431681933 0.0320391737175522 2.621359223300971 8.364077669902912 0.5454888897585024 0.2973249899153176 1.425267849835305 1.6080715320593837 1.318674977748992 0.2709274408896192 0.1466806236090141 0.1070183553885475 0.0202898922491691 0.1053546389470493 0.0233101974365333 +Monooxygenase activity 4 8 2.106899323252496 0.035126307299784 4.043689320388349 8.322815533980583 1.6049222537693364 0.1501440468766332 1.612461779657682 1.2307404965531048 1.237349324058907 0.2369071661653372 0.0145992796040203 0.1244478155008913 0.0021303683071518 0.0037492480554313 0.008785557350241 +Fad binding 6 9 2.097215539172045 0.0359744995363935 3.78883495145631 9.932038834951456 1.575439945642976 0.1698004033102896 1.8828741719818296 1.250336932628077 0.9196006746446306 0.2289411404885479 0.1641763697723149 0.1201219647894398 0.2223047329091382 0.1292409073430241 0.0074494564855197 +Phosphatidylserine binding 5 11 2.0834288466884283 0.037212151133843 2.029126213592233 10.060679611650484 0.6615116985008255 0.3340719518205703 1.5854698894895154 0.9597266622759548 1.1646704221215245 0.2873190862432436 0.1756432640316061 0.1287528218161406 0.0293903981750984 0.0291459656321865 0.001918269568256 +Modified amino acid binding 8 22 2.0743040740679595 0.0380510796912398 4.446601941747573 21.354368932038835 0.8157790161756342 0.4133026066112408 2.099367243274066 1.7995833767593454 0.9656025978141096 0.3166170247143811 0.2821140734943566 0.2106238865633207 0.0775813155228076 0.0009743779436676 0.0004290006789134 +Serine hydrolase activity 6 17 2.066363733866308 0.0387941476035875 6.934466019417476 18.83009708737864 1.2767207242593377 0.1489147276149277 2.386872767465543 1.965791668457755 1.709796217367629 0.2208345231085202 0.004297419425316 0.0230307909850112 0.0108939889611676 0.0009743779436676 0.0079620077053278 +Metallopeptidase activity 14 38 2.063512441009069 0.039063967019439 11.548543689320388 40.60436893203884 1.2053444242445344 0.3510417366391842 4.586289489033314 2.1135899474190585 1.0988837346562612 0.3462572593421246 0.1044145484518049 0.326192706464958 0.0415809882988902 0.1274569302589828 0.0015858816854951 +Acylglycerol o acyltransferase activity 3 6 2.0623914152854024 0.0391704859646668 2.6601941747572817 6.820388349514563 0.8174935736497821 0.2734948556707107 1.708365471336677 1.514259678343348 1.2372108727630755 0.2654117957889352 1.0 1.0 0.1837383274168749 0.4015375820029667 0.017002584405276 +Transmembrane transporter binding 5 25 2.048953406640587 0.0404666712380641 6.233009708737864 30.356796116504853 0.2286793094831162 0.6608453659958601 3.699787145530921 3.1778018639598757 0.6794318171135323 0.2958932397602019 0.0957993890748379 0.0533785743764077 0.1656331484196294 0.1110881847348581 0.0751078057088052 +Transferase activity transferring alkyl or aryl other than methyl groups 7 17 2.0478197306668706 0.040577666304874 6.269417475728155 21.9004854368932 0.1637295171124019 0.5810042550406141 3.4221915209842564 3.50274507569733 0.8797870134307709 0.3068689904123456 0.2568414051025549 0.1908924307699622 0.0640285846884502 0.0195417527514502 0.0168189007239576 +Inorganic anion transmembrane transporter activity 3 14 2.0412042300645776 0.0412305314407051 7.427184466019417 19.274271844660195 1.0921593405593897 0.2441056926448881 3.717191605498929 3.7816647851785734 1.4014196343960104 0.2816216967014333 0.0494389942411911 0.0267403422938185 0.0890100643743446 0.0362911702166911 0.2447590412697401 +Poly purine tract binding 6 14 2.0086738181567965 0.0445717370968683 5.558252427184466 15.1747572815534 -0.0276612113620522 0.6248740742975116 3.405307800747814 1.11195781565948 0.8182388849461438 0.3030179928613766 1.0 1.0 1.0 0.4573561220916043 0.000136356004925 +Nucleocytoplasmic carrier activity 4 20 1.9970049410654889 0.0458246462396816 7.444174757281553 19.67233009708738 0.0634206781641703 0.6193836320949039 4.186117840123668 1.6842823967514435 0.8882318111664522 0.3304839121824445 0.0009964095299817 0.0003706576678266 0.0026246094830452 0.0048864602536943 0.0119362160344991 +Cargo receptor activity 5 8 1.99414434558136 0.0461362821895023 3.7063106796116503 7.95873786407767 0.9623237890522576 0.1578680760704802 1.9530058934839476 1.7914972745396005 1.6202205206532496 0.203966946010782 0.1756432640316061 0.1287528218161406 0.0293903981750984 0.0042924995678 0.001918269568256 +Anion transmembrane transporter activity 6 40 1.9906027403963036 0.0465245787494257 18.594660194174757 45.61893203883495 1.6222323024349488 0.2373683627198559 9.346785472607134 6.017202751823004 1.8117646078257517 0.3183345645365742 0.0108828846648564 0.023691411776477 0.033005107755267 0.0327491618218664 0.1587098655279396 +Active transmembrane transporter activity 9 62 1.984228594954544 0.0472303621806082 26.354368932038835 73.12621359223301 1.313035419122872 0.3239574057550545 11.878456281473593 8.663537710607383 1.88741562841277 0.3851687956916088 0.1613061712683674 0.0762657298482616 0.3072324825572405 0.056003069988558 0.2766878616126544 +Sphingolipid binding 2 5 1.975565878724836 0.0482039663732691 3.2305825242718447 6.810679611650485 1.3881601090528384 0.1287371848492678 1.3662849673921555 1.293404675510669 1.5116584105270494 0.2146285912590262 0.0066216295693603 0.0034296220851759 0.0126574737404708 0.0086586519898169 0.0539281835546241 diff --git a/msigdb_gomf/metrics.json b/msigdb_gomf/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..61eb16e1dc5957d0bce24bf1a6c375cec9ad691f --- /dev/null +++ b/msigdb_gomf/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2812, + "annotations_size": 1344, + "title": "Average number of proteins per term", + "value": 15.146577380952381 +} \ No newline at end of file diff --git a/msigdb_gomf/paths.json b/msigdb_gomf/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..7cb827cc9d6a5a275ccc703a1b6a0b4a82251117 --- /dev/null +++ b/msigdb_gomf/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_gomf/fragment/C428/C428_val_log2fc"} \ No newline at end of file diff --git a/msigdb_gomf/result.tsv b/msigdb_gomf/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..eab76e6d5a834b2c8d73fa1c90c3c5daab6015a4 --- /dev/null +++ b/msigdb_gomf/result.tsv @@ -0,0 +1,425 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Peptide binding 0.6090228818371736 3.915083443100864 9.037294743508006e-05 0.1143794826251479 0.051333016949187 69 P55786,Q15392,O15212,O43813,P40855,Q6P179,Q9UIQ6,O00264,P04439,O00505,Q01650,P55899,Q8WTV0,Q9Y287,Q92973,O00629,P01889,P52294,Q9NZ08,P21266,O60684,P61758,P30414,P10321,Q9UHB9,Q9NXR7,P42892,O14773,Q07954,Q9H7Z7,Q9BYT8 31 +Peptidase activity 0.5290123038154411 3.85743608700521 0.0001145826271187 0.1427347294043204 0.051333016949187 102 Q99829,Q96FW1,P42785,P49721,O75976,Q6P179,Q9UIQ6,Q9UPU5,Q5JRX3,P09960,P07858,Q9HB40,Q8TEY7,Q96FZ2,P28072,O75844,P49720,Q8TCT9,P10619,P28074,Q99436,Q92820,P42892,Q96K76,Q16740,O14773,P20618,P28070,P60900,Q9BYT8,Q96RU2 31 +Transporter activity 0.5314663237627096 3.711403482869239 0.0002061132581661 0.2419794411819975 0.0692540547438124 155 P30536,Q9NS69,Q99595,O60830,Q70HW3,P21796,Q9C0H2,P45880,Q96ES6,Q8NHS3,P36543,P53985,O75964,Q8WTV0,O43676,Q9Y487,Q93050,Q8IXU6,O15173,Q5SR56,Q9UBX3,Q9H2D1,O43772,Q9Y619,O15118,P08183,P04062,Q8NE01,Q9HD20,Q07820,O75306,P47985,Q9Y6M9,P17900 34 +Hydrolase activity acting on glycosyl bonds 0.7352993610437977 3.549754108219247 0.0003855911289152 0.4044884031647888 0.0992831010987063 25 P16278,Q9BTY2,P06280,P35573,P10253,P54802,P08236,O75503,P06865,P04062,P17900,Q9NUJ1,O60502,Q8IW92 14 +Steroid binding 0.7632585528039156 3.3735687300134045 0.0007420052007964 0.6312458647622861 0.1424649985529244 22 P30536,Q9BZF1,P21796,P45880,O15118,O15173,Q14108,P04062,O00264 9 +Phospholipid binding 0.5337078963220372 3.3301374922640803 0.0008680310999114 0.6887442721657852 0.1453072451529874 76 Q99829,P30086,P21796,O76054,Q9UKG1,P04083,P45880,P07737,Q8WTV0,Q9BZF1,P50897,Q92783,P50995,Q14108,Q8NCC3,O60443,O14773,P07602,O14964,P35080,Q06481 21 +Lipid binding 0.4934837002080923 3.2982081935737537 0.000973039588078 0.7297483921719471 0.1453072451529874 125 P30536,P30086,A6NIH7,Q99829,Q13432,P29375,P21796,O76054,Q9UKG1,P45880,P04083,O15254,P07737,Q9BQE5,O00264,P61916,Q8WTV0,Q9BZF1,O15173,O95772,P50897,Q92783,P11717,P50995,O15118,Q14108,Q8NCC3,P04062,O60443,O14773,P07602,O14964,Q06481,P28070,P35080 35 +Hydrolase activity hydrolyzing o glycosyl compounds 0.8082421021710487 3.2441094996776463 0.0011781844408365 0.7949319569300524 0.1543666587364729 18 P16278,P35573,P06280,Q9BTY2,P10253,P54802,P08236,P06865,P04062,Q8IW92,Q9NUJ1,O60502,P17900 13 +Endopeptidase activity 0.554467980034807 3.2017643315502524 0.0013658869397921 0.8407065061060588 0.1543666587364729 59 P49721,Q6P179,Q9UPU5,Q5JRX3,P07858,Q8TEY7,P28072,O75844,P49720,Q8TCT9,P28074,Q99436,P42892,Q96K76,Q16740,O14773,P20618,P28070,P60900,Q9BYT8,Q96RU2 21 +Exopeptidase activity 0.6581915074704057 3.12853827963738 0.0017567812601411 0.9058805375326276 0.1543666587364729 29 Q99829,P10619,Q9HB40,O14773,P55786,Q92820,P42785,O75976,Q6P179,O75844,Q9UIQ6,P09960 12 +Protein transporter activity 0.8202693217840255 3.0224955223110963 0.0025069979172607 0.9657351701256768 0.1543666587364729 14 Q99595,O60830,Q9HD20,Q9NS69 4 +Sterol binding 0.7527441918673616 2.8576635926005647 0.0042677258064574 0.9968111594103902 0.1543666587364729 17 P30536,Q9BZF1,P21796,P45880,O15118,Q14108 6 +Protein transmembrane transporter activity 0.8306727552526292 2.7569332034990066 0.0058346269073101 0.9996159373044942 0.1543666587364729 11 Q99595,Q9NS69 2 +Cholesterol binding 0.7670907103923079 2.7474324685053806 0.0060063876770062 0.999695526375118 0.1543666587364729 14 P30536,Q9BZF1,P21796,P45880,O15118,Q14108 6 +Macromolecule transmembrane transporter activity 0.8002285236848076 2.7041951950026872 0.0068470054819518 0.9999023405640108 0.1543666587364729 12 Q99595,Q9NS69 2 +Alcohol binding 0.7230826842085647 2.6902986452671094 0.0071388101205611 0.999934205317866 0.1543666587364729 17 P30536,P29375,Q9BZF1,P21796,P45880,O15118,Q14108 7 +Threonine type peptidase activity 0.8873246927674877 2.6144405821107073 0.0089373704314283 0.9999942472060044 0.158112428797831 8 P28074,P20618,Q99436,P28072,P28070,P49721 6 +Threonine type endopeptidase activity 0.8873246927674877 2.6144405821107073 0.0089373704314283 0.9999942472060044 0.158112428797831 8 P28074,P20618,Q99436,P28072,P28070,P49721 6 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 0.6114999511904132 2.6058373404355213 0.0091649974089254 0.9999957752475672 0.1599708638648797 24 Q32P28,Q16850,Q8NB78,P29375,P09601,P30519,Q15800,P13674 8 +Nuclear localization sequence binding 0.7274942697257814 2.5365972828691423 0.0111935637465665 0.9999997311150236 0.1823001920892802 14 O00505,O00629,O60684,P52294 4 +Ion transmembrane transporter activity 0.4241269368622852 2.534583103891485 0.011258121981704 0.9999997537044246 0.1823001920892802 91 Q9HD20,O75964,Q9Y487,Q70HW3,Q93050,P21796,O43772,Q9C0H2,Q9Y619,P45880,Q96ES6,P36543,P53985,Q9UBX3,Q9H2D1 15 +Molecular transducer activity 0.5605122792819673 2.4557525195865884 0.0140589939438717 0.9999999945593672 0.2076405259402601 31 P30536,Q8WTV0,P15260,P11717,Q5KU26,Q07954,Q4VCS5,Q99523,O15118,O43813,O15173,Q14108,Q15629,Q6RW13,P10586 15 +Nuclear import signal receptor activity 0.7387224963049708 2.394655491065871 0.0166359880317648 0.9999999998385518 0.2216905357387301 12 O00505,O00629,O60684,P52294 4 +Serine type exopeptidase activity 0.8517468948436883 2.3596053115864897 0.0182943874720611 0.9999999999832956 0.2364197765620208 7 P10619,O14773,Q9HB40,P42785 4 +Anion channel activity 0.8245874520818687 2.3412701769128708 0.0192182540392618 0.9999999999952872 0.2367825808765379 8 P45880,P21796 2 +Tetrapyrrole binding 0.6912373090382331 2.3388889484791195 0.0193411816076614 0.999999999996018 0.2367825808765379 14 Q16850,P09601,Q8WUJ1,O15173,Q9H7Z7,P30519 6 +Amide binding 0.4104787035948911 2.336406619840803 0.0194700592670977 0.9999999999966628 0.2367825808765379 99 Q15392,P55786,P21796,P45880,Q96AY3,Q6P179,Q9UIQ6,O00264,P04439,O00505,P55899,Q01650,Q8WTV0,Q9Y287,Q92973,O00629,P52294,P01889,Q9NZ08,P21266,P62942,O60684,P61758,P10321,Q9UHB9,Q9NXR7,P42892,O14773,P07602,P00374,Q07954,Q9H7Z7,Q9BYT8 33 +Signal sequence binding 0.5731536473336928 2.3352810984267185 0.0195287409306181 0.9999999999969206 0.2367825808765379 24 O00505,Q92973,O00629,P52294,Q9NXR7,O60684 6 +Exogenous protein binding 0.701122037237621 2.2916438671536943 0.0219262019684329 0.9999999999998852 0.2416373995499712 13 O15118,Q14108,Q8WTV0 3 +Ubiquitin binding 0.551359776583051 2.291502849069094 0.0219343472805777 0.9999999999998866 0.2416373995499712 26 Q9Y679,Q96FW1,Q8TEY7,Q92783,O14964,Q9Y3I1,P04792,Q9Y263,Q8IXJ6,Q13501 10 +Mrna 3 utr binding 0.4866864528615327 2.2573896041366397 0.0239837407406833 0.9999999999999932 0.2545265402316516 49 Q96B26,P16989,P51116,Q5VTR2,Q13310,P35637,P22626,P11940,Q92945,Q14671,P31483,P51114,Q92804,Q71RC2,Q9BWF3,Q14011,Q14103,Q06787,Q01085 19 +Glycolipid binding 0.7962218974659294 2.214772382707854 0.0267756917362522 1.0 0.2665668866186892 8 O14773,P50897 2 +Mirna binding 0.6834763651000754 2.196587185190903 0.0280499422686757 1.0 0.2741308830249911 13 P67809,Q06787,P98175,Q8IWR0,Q14671,Q9BWF3,P22626 7 +Phospholipase activity 0.6832250940136123 2.1952263157979077 0.0281473674534589 1.0 0.2741308830249911 13 Q8IV08,Q8NHP8,Q8NCC3,P09601 4 +Lipase activity 0.6832250940136123 2.1952263157979077 0.0281473674534589 1.0 0.2741308830249911 13 Q8IV08,Q8NHP8,Q8NCC3,P09601 4 +Peptide antigen binding 0.8528153955808959 2.180630223389476 0.0292107778056684 1.0 0.2804234669344175 6 P10321,P55899,P01889,Q15392,P04439 5 +O acyltransferase activity 0.762745309320963 2.163900377555038 0.0304719959641641 1.0 0.2867012131175212 9 Q99943,P23786,Q8NCC3,Q8NF37 4 +Phosphatidylcholine binding 0.8063124353941364 2.1634749580193673 0.0305046677647362 1.0 0.2867012131175212 7 P45880,P21796 2 +Symporter activity 0.8474167527056371 2.1582786980261393 0.0309061699019166 1.0 0.2877493583272139 6 Q96ES6 1 +Amyloid beta binding 0.7075923607520722 2.1498228295863653 0.0315692316460201 1.0 0.288997647492552 11 Q8WTV0,Q9Y287,P61758,O15212,Q07954,P30533,O00264,Q9NQP4 8 +Quaternary ammonium group binding 0.7072664142578758 2.148156651812005 0.0317013130114416 1.0 0.288997647492552 11 P45880,P21796 2 +Ubiquitin like protein binding 0.5237643217225423 2.145084043629512 0.0319461279711648 1.0 0.288997647492552 30 Q9Y679,Q96FW1,Q8TEY7,Q92783,O14964,Q9Y3I1,P04792,Q96GG9,Q9Y263,Q8IXJ6,Q13501 11 +Sterol transporter activity 0.7584851221566252 2.1439215431681933 0.0320391737175522 1.0 0.288997647492552 9 P30536,O15118,Q9BZF1 3 +Monooxygenase activity 0.7723575943683446 2.106899323252496 0.035126307299784 1.0 0.3105905066507222 8 Q15800,Q16850,P30519,P09601 4 +Fad binding 0.7485630283645446 2.097215539172045 0.0359744995363935 1.0 0.3160112900451824 9 Q8NB78,Q15067,Q15392,O00116,O15254,Q14534 6 +Phosphatidylserine binding 0.6946504416198103 2.0834288466884283 0.037212151133843 1.0 0.3190505957488878 11 Q99829,Q8WTV0,Q9BZF1,Q06481,Q14108 5 +Modified amino acid binding 0.5624917700438203 2.0743040740679595 0.0380510796912398 1.0 0.3190505957488878 22 Q99829,Q8WTV0,Q9BZF1,Q06481,P21266,Q14108,P00374,Q9H7Z7 8 +Serine hydrolase activity 0.6173355313087502 2.066363733866308 0.0387941476035875 1.0 0.3190614129485593 17 P10619,O14773,Q9HB40,P42785,Q5JRX3,Q16740 6 +Metallopeptidase activity 0.4944098444925093 2.063512441009069 0.039063967019439 1.0 0.3190614129485593 38 Q99829,Q9BYT8,P52888,P55786,Q9NZ08,Q10713,O75976,P42892,Q6P179,Q9NQH7,Q9UIQ6,O75844,Q5JRX3,P09960 14 +Acylglycerol o acyltransferase activity 0.8244082173230067 2.0623914152854024 0.0391704859646668 1.0 0.3190614129485593 6 Q99943,Q8NCC3,Q8NF37 3 +Transmembrane transporter binding 0.5207644969824388 2.048953406640587 0.0404666712380641 1.0 0.3265651707410221 25 P30536,P42858,P21796,P62942,Q9Y4C2 5 +Transferase activity transferring alkyl or aryl other than methyl groups 0.6143001294940889 2.0478197306668706 0.040577666304874 1.0 0.3265651707410221 17 P49356,P78417,P21266,O00116,O43813,Q92696,P37268 7 +Inorganic anion transmembrane transporter activity 0.6381351479163722 2.0412042300645776 0.0412305314407051 1.0 0.3278925103923529 14 P45880,P21796,Q9C0H2 3 +Poly purine tract binding 0.6324335864282246 2.0086738181567965 0.0445717370968683 1.0 0.3425902631273402 14 Q06787,P11940,O14979,Q13310,Q71RC2,Q07666 6 +Nucleocytoplasmic carrier activity 0.5749306854861831 1.9970049410654889 0.0458246462396816 1.0 0.3454642753548518 20 O60684,O00505,O00629,P52294 4 +Cargo receptor activity 0.7477182560604693 1.99414434558136 0.0461362821895023 1.0 0.3454642753548518 8 Q8WTV0,O15260,Q08380,Q14108,Q07954 5 +Anion transmembrane transporter activity 0.4823427412501982 1.9906027403963031 0.0465245787494257 1.0 0.3454642753548518 40 P21796,Q9C0H2,P45880,P53985,Q9UBX3,Q9H2D1 6 +Active transmembrane transporter activity 0.4341297869621635 1.984228594954544 0.0472303621806082 1.0 0.3487780591798765 62 Q9HD20,O43676,Q96ES6,P08183,O75306,P47985,P36543,P53985,Q9UBX3 9 +Sphingolipid binding 0.8734836757027035 1.975565878724836 0.0482039663732691 1.0 0.3501953016522907 5 P45880,P21796 2 +Voltage gated anion channel activity 0.8691005956886119 1.9582010121780875 0.0502064304192355 1.0 0.3627819488357666 5 P21796 1 +Serine type carboxypeptidase activity 0.8661913537580563 1.9466590050755512 0.0515756295025233 1.0 0.3667600320179439 5 P10619,Q9HB40,P42785 3 +Metalloexopeptidase activity 0.5738845684960819 1.9165343014677945 0.0552971214364683 1.0 0.3786702097652056 19 Q99829,P55786,O75976,Q6P179,O75844,Q9UIQ6,P09960 7 +Hexosaminidase activity 0.858466909567914 1.91595121218782 0.0553713059819958 1.0 0.3786702097652056 5 P54802,O60502,P06865 3 +Secondary active transmembrane transporter activity 0.5918243075703898 1.909438453301322 0.0562055542333306 1.0 0.3786702097652056 17 P53985,Q96ES6 2 +Mannose binding 0.7480495933677538 1.905441563270666 0.0567226967804446 1.0 0.3786702097652056 7 P35613,Q12907,O75503,P11717 4 +Poly a binding 0.6601293550842134 1.9039766066384616 0.0569132309319728 1.0 0.3786702097652056 11 P11940,O14979,Q13310,Q71RC2,Q07666 5 +Monosaccharide binding 0.4976040664185637 1.8806961518483936 0.0600132634495536 1.0 0.3939667984119519 26 Q32P28,P11717,Q5KU26,P35613,Q12907,O75503,P13807,P13674 8 +Organic acid transmembrane transporter activity 0.5574456426924613 1.8801204649403271 0.0600916619601563 1.0 0.3939667984119519 20 Q9Y619,P53985,Q9UBX3,Q9H2D1 4 +Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor 0.6092755191238347 1.875445523162326 0.0607314573673771 1.0 0.3948074728790042 14 Q15392,Q14914,Q9BY49,Q8N4Q0,Q9H7Z7 5 +Carboxypeptidase activity 0.6545947080866257 1.8748933220450548 0.0608074009568109 1.0 0.3948074728790042 11 O75976,P10619,Q9HB40,P42785 4 +Inorganic molecular entity transmembrane transporter activity 0.4210792600926945 1.865443464041142 0.0621192698366024 1.0 0.3994655438296348 65 Q9HD20,Q9Y487,Q93050,P21796,Q9C0H2,P45880,Q96ES6,P36543,O75964,Q9UBX3 10 +Ceramide binding 0.9514119615477978 1.85474165773021 0.0636331269292393 1.0 0.404422979783388 4 P45880,P21796 2 +Omega peptidase activity 0.5062779429729091 1.844374521337843 0.0651285778278978 1.0 0.404422979783388 24 Q96FW1,Q8TEY7,Q92820,Q9H8M7,Q96K76,Q9UPU5,Q96RU2 7 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen 0.972241992882564 1.841192043332856 0.0655934209443853 1.0 0.404422979783388 2 P30519 1 +Phospholipase d activity 0.9722419928825624 1.8411920433328488 0.0655934209443864 1.0 0.404422979783388 2 Q8IV08 1 +Regulatory rna binding 0.595856860143957 1.8370534058723111 0.0662020116991553 1.0 0.4044341078348396 15 P67809,Q06787,P98175,Q8IWR0,Q14671,Q9BWF3,P22626 7 +Lysophosphatidic acid binding 0.9647686832740224 1.8107405012836293 0.0701810302833974 1.0 0.4210861817003843 2 P50897 1 +Protein methyltransferase activity 0.5118305846168446 1.7979384769257434 0.072186757839765 1.0 0.4297479799298868 23 Q9BYW2,Q9H993,O60725,O96028,Q9H7B4,Q86X55,Q03164,Q9BV86 8 +Scavenger receptor activity 0.8275739223370104 1.7922608515523155 0.0730911911637999 1.0 0.43085333738661 5 Q07954,Q08380,Q8WTV0,Q14108 4 +5 3 exodeoxyribonuclease activity 0.9583629893238448 1.7846033091015396 0.0743256842992661 1.0 0.4362171165860858 2 Q8IV08 1 +Palmitoyl protein hydrolase activity 0.8232443466611555 1.7748174593591903 0.0759280325466078 1.0 0.4368176521307503 5 P50897,Q9UMR5 2 +Wide pore channel activity 0.9293773072791828 1.7720992315477286 0.0763780864960761 1.0 0.4368176521307503 4 P21796 1 +Porin activity 0.9293773072791828 1.7720992315477286 0.0763780864960761 1.0 0.4368176521307503 4 P21796 1 +Antigen binding 0.6976013250983766 1.760605226818786 0.0783052433611275 1.0 0.4440601142504448 8 P10321,P55899,Q01650,Q15392,P01889,P04439 6 +Iron ion binding 0.5743576412398628 1.7514661720905529 0.0798656433140336 1.0 0.4510059857733666 16 Q32P28,Q16850,Q9BU89,Q15800,Q9C0B1,P13674 6 +Lipid transporter activity 0.5379376135541667 1.748232532937335 0.0804237703627279 1.0 0.4522575203661355 20 P30536,Q9BZF1,O15118,P08183,P17900 5 +Sulfur compound transmembrane transporter activity 0.7498411591489687 1.744873190735709 0.0810069449600709 1.0 0.4536388917763975 6 Q70HW3,Q9UBX3 2 +Carbohydrate binding 0.4501819466030031 1.732992210484644 0.083097053307434 1.0 0.4634126126356485 42 Q32P28,Q86SF2,P17931,P11717,Q5KU26,Q10472,P35573,P35613,P10253,Q12907,P08236,O75503,P13807,P13674 14 +N acyltransferase activity 0.5627979505886739 1.728039583274225 0.0839811279670326 1.0 0.4661727217500178 17 P30419,Q96G23,Q86UY6 3 +Beta galactosidase activity 0.9434163701067636 1.7234980663625985 0.0847984945480808 1.0 0.4661727217500178 2 Q8IW92 1 +Hormone binding 0.689657256084214 1.7230938061063412 0.084871562736132 1.0 0.4661727217500178 8 P30536 1 +Beta 2 microglobulin binding 0.9427046263345196 1.7205844504019605 0.08532625710603 1.0 0.4661727217500178 2 P04439 1 +Galactoside binding 0.9387900355871884 1.7045537677776668 0.0882776800761182 1.0 0.4761785840274954 2 P16278 1 +Metalloendopeptidase activity 0.5797207554080474 1.7029635738485411 0.0885748854217811 1.0 0.4761785840274954 14 P52888,Q10713,P42892,O75844,Q5JRX3,Q9BYT8 6 +Lipid transfer activity 0.7322376181271777 1.6685021903526525 0.095216077480646 1.0 0.495943815250716 6 P30536,Q9BZF1 2 +Lysophospholipid acyltransferase activity 0.7966146885824619 1.6669794402937947 0.0955184931120993 1.0 0.495943815250716 5 Q99943,Q8NF37 2 +Polyubiquitin modification dependent protein binding 0.6022065235449316 1.6667078759502216 0.09557250606394 1.0 0.495943815250716 12 P35573,P46379,Q9NXR7 3 +Serine type endopeptidase inhibitor activity 0.7944037682866316 1.6579855054560335 0.0973203920047747 1.0 0.5011440875648169 5 P30086 1 +Translation repressor activity 0.6552999134032191 1.6466575412502225 0.0996284559795426 1.0 0.5020720260766028 9 Q9BPZ3,Q14011,P00374 3 +Cation transmembrane transporter activity 0.4012673530100203 1.6298632119327925 0.1031304103150216 1.0 0.5095855568506954 64 Q9HD20,Q9Y487,Q70HW3,Q93050,O43772,Q9Y619,Q96ES6,P36543,O75964 9 +Mhc protein complex binding 0.6649725040306292 1.6057369241718178 0.1083317247216959 1.0 0.5333254140145031 8 Q9NUQ9 1 +Glucosidase activity 0.7805750003727614 1.6015983630266302 0.1092444530440295 1.0 0.5347284164537138 5 P10253,P04062 2 +Protein tyrosine kinase activity 0.6239764452747633 1.595475132261892 0.110606026617658 1.0 0.5347284164537138 10 Q02750,P45985,P11717 3 +Scaffold protein binding 0.5538955196319495 1.584926498655161 0.1129830350931166 1.0 0.5433147893734336 15 Q16543,P07602,P08670,Q02750,Q9UQB8 5 +Collagen binding 0.6601663506671784 1.5827541396638494 0.1134775131691885 1.0 0.5433147893734336 8 Q32P28,Q92791,P07858 3 +Carboxylic ester hydrolase activity 0.4586779364324747 1.5734092612042674 0.1156240839397848 1.0 0.5433147893734336 26 Q9NUJ1,P35790,Q8NCC3,Q15165 4 +Molecular carrier activity 0.4535398098921896 1.5733469281874184 0.1156385086191444 1.0 0.5433147893734336 30 O60684,O00505,O00629,P52294 4 +Protein phosphatase regulator activity 0.5446670188942349 1.568038092379988 0.116872242757398 1.0 0.5433147893734336 16 P78318,Q01105,Q12972,P30153,Q86XL3,P17931,P30154 7 +Organic cation transmembrane transporter activity 0.8742673210793952 1.5633965151541571 0.1179593593252081 1.0 0.5433147893734336 4 Q70HW3 1 +Prenyltransferase activity 0.7694585270002356 1.5561139253330802 0.1196810042470799 1.0 0.5433147893734336 5 P49356,Q92696 2 +Lysine acetylated histone binding 0.6536544026001658 1.551549125031304 0.1207701442956854 1.0 0.5433147893734336 8 Q03164 1 +Sulfatide binding 0.9598170948473266 1.5267721064422308 0.1268176899767668 1.0 0.5560787452754811 3 P50897 1 +Cysteine type peptidase activity 0.4315812415044202 1.5141939957741448 0.1299766440881544 1.0 0.5598993899182038 39 Q96FW1,Q8TEY7,Q96RU2,P40818,Q92820,Q99496,Q92905,O43292,Q9BT78,Q9H8M7,Q96K76,Q9UPU5,P07858 13 +Structural constituent of muscle 0.6591037935288211 1.4984326438808202 0.1340208803980469 1.0 0.5646522359090128 7 Q12797,P60660,P14649 3 +Isoprenoid binding 0.8839857651245545 1.4793806918871764 0.1390385975553965 1.0 0.5774836103933331 2 P29375 1 +Guanylate kinase activity 0.8804270462633526 1.4647332492066372 0.1429937097793254 1.0 0.5854400652663954 2 O14936 1 +Phosphotyrosine residue binding 0.7453944487752593 1.457228809924011 0.1450532304566292 1.0 0.5854400652663954 5 P46109,P07737,Q06124 3 +Histone methyltransferase activity h3 k36 specific 0.8779359430605049 1.4544799644304398 0.1458132843046899 1.0 0.5861692317689353 2 O96028 1 +Galactosidase activity 0.9391242435030256 1.450909152593116 0.1468051589675849 1.0 0.5861692317689353 3 P16278,Q8IW92 2 +Single stranded rna binding 0.4245386407636176 1.4493341806332447 0.1472442800043283 1.0 0.5861692317689353 39 P31943,Q06787,P11940,P52597,O14979,Q13310,Q71RC2,P23588,P51114,Q07666 10 +Protein phosphatase 2a binding 0.6484371364208519 1.448724328308429 0.1474145835847471 1.0 0.5861692317689353 7 Q86XL3 1 +Ubiquitin conjugating enzyme binding 0.68122235102136 1.444603278692882 0.1485693513243111 1.0 0.586636117850082 6 Q9Y679,Q96GG9 2 +Atpase coupled transmembrane transporter activity 0.510374831903835 1.4405409048050075 0.1497144259096563 1.0 0.586636117850082 18 Q9HD20,P38606,P08183,P36543,Q15388,P21283,P61421 7 +Atpase coupled cation transmembrane transporter activity 0.547908589620768 1.4345818783682147 0.1514062815969707 1.0 0.5866734935071171 13 Q9HD20,P21283,P61421,P36543 4 +Beta n acetylhexosaminidase activity 0.8395148604388546 1.4306524827195397 0.1525298379462396 1.0 0.5866734935071171 4 O60502,P06865 2 +Isocitrate dehydrogenase activity 0.8390366092740751 1.4288214842023483 0.1530555489331098 1.0 0.5866734935071171 4 P48735 1 +Lipoprotein particle receptor activity 0.8661921708185171 1.4061489684255537 0.1596798940195094 1.0 0.5943995716689398 2 Q8WTV0 1 +Phosphoric diester hydrolase activity 0.5846044696355226 1.3906126525259126 0.1643429175119131 1.0 0.6053027754735231 10 Q8IV08,P09601 2 +Oligopeptide binding 0.7278510079801567 1.384833315193263 0.1661034413914135 1.0 0.608291621880272 5 Q9H7Z7,P21266 2 +Thiolester hydrolase activity 0.5247117762117289 1.375674707303323 0.1689223659018734 1.0 0.6086639672174744 14 P50897,Q9UMR5 2 +O methyltransferase activity 0.6641834365707132 1.3691209502856638 0.1709614705303861 1.0 0.6143642149541149 6 O60725,P21964 2 +Single stranded dna exodeoxyribonuclease activity 0.8202440622179697 1.3568138580001827 0.1748403630993453 1.0 0.6243383428307805 4 Q8IV08,Q9UQ84 2 +Map kinase kinase activity 0.7179872991559859 1.3440417901708943 0.1789348736117459 1.0 0.6312033336855292 5 Q96KB5,Q02750,P45985 3 +Arylesterase activity 0.8494661921708295 1.3373666636660966 0.1811029804717383 1.0 0.6338604316510842 2 Q15165 1 +Endopeptidase regulator activity 0.4493842578645364 1.3321043566077355 0.1828258989505724 1.0 0.6339218311686209 23 P30086 1 +Atpase activator activity 0.5417206548321574 1.3283098368049684 0.1840757714148932 1.0 0.6343534276451707 12 Q8NFQ8,Q99543 2 +Hsp70 protein binding 0.5158256067517213 1.3222242139909033 0.1860935002578656 1.0 0.6396666607329192 14 Q99543,P46379 2 +Protein self association 0.551122524034706 1.3173626250406696 0.187717102637767 1.0 0.6419638319215241 11 Q9Y282 1 +Gated channel activity 0.5384949891355115 1.3100797907361577 0.1901688443120326 1.0 0.6427144578814461 12 P45880,P21796 2 +Histone methyltransferase activity 0.5034372871689177 1.3096104704976863 0.1903276445214401 1.0 0.6427144578814461 16 Q99873,O96028,Q9H7B4,Q86X55,Q9BYW2,Q03164,Q9BV86 7 +Abc type transporter activity 0.7047919893173622 1.2894003964143597 0.1972589236817354 1.0 0.6485799097191526 5 Q9HD20 1 +Ubiquitin like protein specific protease activity 0.4209022739673551 1.2892702301381032 0.1973041567561502 1.0 0.6485799097191526 29 Q96FW1,Q8TEY7,Q96RU2,P40818,Q99496,Q92905,Q9BT78,Q9H8M7,Q96K76,Q9UPU5,Q93009,Q7L5N1 12 +Aspartic endopeptidase activity intramembrane cleaving 0.8377224199288238 1.2891454129038329 0.197347538156495 1.0 0.6485799097191526 2 Q8TCT9 1 +Acyl coa oxidase activity 0.8373665480427062 1.2876854558604762 0.1978554784113486 1.0 0.6485799097191526 2 O15254 1 +Pentosyltransferase activity 0.5015897184911382 1.2645169562610197 0.2060445385836009 1.0 0.6590769105798976 15 Q13126 1 +Hydrolase activity acting on ether bonds 0.6089094537100507 1.2633534451056827 0.20646218707778 1.0 0.6590769105798976 7 P07099,P09960 2 +Tap binding 0.8867924528301944 1.258940457750245 0.208051839158192 1.0 0.6590769105798976 3 P01889,P04439 2 +Protein phosphorylated amino acid binding 0.5921176812438922 1.2536187365509937 0.209980617658789 1.0 0.6590769105798976 8 P46109,P07737,Q06124 3 +Acyltransferase activity 0.3940772842685079 1.2487179075509451 0.2117682687215329 1.0 0.6590769105798976 45 Q86UY6,P30419,Q8NF37,Q969G3,O15270,P23786,Q8NCC3,Q9BWD1,Q99943,Q96G23 10 +Receptor tyrosine kinase binding 0.5153974484238519 1.2452823751914883 0.2130279719227121 1.0 0.6590769105798976 13 P46109,Q06124,O75312 3 +Pattern recognition receptor activity 0.8266903914590902 1.2439304319899578 0.2135251679573693 1.0 0.6590769105798976 2 Q8WTV0 1 +Low density lipoprotein particle binding 0.8266903914590902 1.2439304319899578 0.2135251679573693 1.0 0.6590769105798976 2 Q8WTV0 1 +Vitamin transmembrane transporter activity 0.6358664534263143 1.243163233086213 0.2138076882535977 1.0 0.6590769105798976 6 Q9H2D1 1 +Molecular function activator activity 0.5145467960195592 1.2403124451476584 0.2148598510229342 1.0 0.6596825056206049 13 Q8NFQ8,Q99543 2 +Proton transmembrane transporter activity 0.4043034655936286 1.2292584253719934 0.218974929584903 1.0 0.6658423198237776 35 Q9Y487,Q93050,Q96ES6,P36543,O75964 5 +Rna strand annealing activity 0.6878180004659056 1.2190410597718169 0.2228286086843618 1.0 0.6745082208823926 5 P51114,Q06787 2 +G protein alpha subunit binding 0.6858294139313666 1.2107962263686112 0.2259735118225498 1.0 0.6800844097283614 5 P80303,P11717 2 +Zinc ion binding 0.3453274749264663 1.206611737188696 0.2275817044593984 1.0 0.6800844097283614 125 Q99829,Q9NRW3,P55786,P29375,O75976,Q6P179,Q03164,Q9UIQ6,O75312,Q5JRX3,Q8N4Q0,P09960,Q8TEY7,P49356,Q9NZ08,O43823,Q92696,O15344,Q9NUD5,Q8IXK0,Q5JTZ9,Q8NCC3,P42892,Q9BWF3,Q8NB78,Q15437,P19474 27 +Oxidoreductase activity acting on the ch ch group of donors 0.4126198082525 1.2062894706245124 0.2277058961373019 1.0 0.6800844097283614 27 Q14739,P21912,Q14914,Q15392,Q9BY49,Q8N4Q0,Q9H7Z7 7 +Signaling receptor binding 0.3530706563628198 1.204358072677303 0.2284512099577325 1.0 0.6800844097283614 145 Q9H2J4,P68371,P14174,P04083,P08236,O75312,Q9BY49,Q9BQE5,P04439,Q8TEY7,P11233,Q9UMX5,P01889,Q9Y5X3,Q9NZ08,P06280,P46379,Q92990,P43490,P62942,P46109,Q8WXW3,Q92542,Q9NXR7,P04062,Q9NUQ9,Q13501,Q06124,Q92896,Q07954,Q9UBS4,P07437,Q9Y624,O14936 34 +Protein tyrosine kinase binding 0.4859311734568938 1.1990447913001787 0.2305105295023628 1.0 0.6804209701415179 16 P46109,Q07666,Q06124,O75312 4 +Procollagen proline dioxygenase activity 0.8654671570110675 1.1809394948348022 0.2376267602632491 1.0 0.6898176964696408 3 Q32P28 1 +Peptidyl proline dioxygenase activity 0.8654671570110675 1.1809394948348022 0.2376267602632491 1.0 0.6898176964696408 3 Q32P28 1 +Modification dependent protein binding 0.385312660176367 1.179940995020808 0.2380236835558338 1.0 0.6898176964696408 46 O14646,Q15022,Q06787,P29375,P35573,P46379,Q9NXR7,P83916,Q9UFC0,Q86X55,Q03164,Q99543,Q13501 13 +Poly pyrimidine tract binding 0.492201736174601 1.1797002347006316 0.2381194605223662 1.0 0.6898176964696408 14 P31943,Q06787,P11940,Q13310,Q07666 5 +Pdz domain binding 0.5151685350722051 1.1779429012987848 0.2388193702592365 1.0 0.6898176964696408 12 Q8IUD2,Q9Y624,Q9UQB8 3 +Voltage gated channel activity 0.5441548646158738 1.177843995022724 0.2388588056972955 1.0 0.6898176964696408 10 P21796 1 +Peroxisome targeting sequence binding 0.8103202846975202 1.1770442073403684 0.2391778620199796 1.0 0.6898176964696408 2 Q9NXR7 1 +Atpase binding 0.4062237045915141 1.1538026840849145 0.2485810735173332 1.0 0.7022266165033274 27 P11233,Q9Y487,Q92542,Q93050,P40855,P36543,Q8NFQ8,Q16740 8 +Demethylase activity 0.5565602805478391 1.1514225744301507 0.2495584311406644 1.0 0.7022266165033274 9 Q8NB78,P29375,Q16850 3 +Protein prenyltransferase activity 0.8573083721001415 1.151175680292612 0.249659968160522 1.0 0.7022266165033274 3 P49356 1 +Vitamin d binding 0.8039145907473468 1.1509562368819684 0.2497502400956774 1.0 0.7022266165033274 2 P04062 1 +Organic anion transmembrane transporter activity 0.404552771063743 1.1454317271829153 0.2520303618514978 1.0 0.7039266573013447 28 Q8TB61,Q9Y619,P53985,Q9UBX3,Q9H2D1 5 +Annealing activity 0.5693544333351495 1.1425224895367836 0.2532369033648507 1.0 0.7039266573013447 8 P51114,Q06787 2 +Ubiquinone binding 0.8010676156583754 1.1393794884900648 0.2545449073277184 1.0 0.7039266573013447 2 P21912 1 +Metalloaminopeptidase activity 0.5179018346972257 1.1345212059056822 0.256575983703557 1.0 0.7053413181564903 11 Q9UIQ6,P55786,P09960,Q6P179 4 +Exodeoxyribonuclease activity 0.5522649715238575 1.12966596973943 0.2586170017437204 1.0 0.7053413181564903 9 Q8IV08,Q9UQ84 2 +Translation initiation factor binding 0.4746683404684522 1.1278148617411532 0.2593981155674258 1.0 0.7057309055113772 16 P55010,O15514,Q06787,O75312 4 +Signaling receptor regulator activity 0.4780439126530448 1.1191137633814496 0.263091608887839 1.0 0.7106743973413382 15 P43490,Q9UMX5 2 +Oxidoreductase activity acting on a sulfur group of donors 0.4017336357836724 1.113389516657808 0.2655411754253602 1.0 0.7123499795842 26 O95881,Q9UHG3 2 +Lrr domain binding 0.7925266903914556 1.1047223864937843 0.2692799000498664 1.0 0.7152414736502382 2 Q96IZ0 1 +Leucine zipper domain binding 0.7925266903914556 1.1047223864937843 0.2692799000498664 1.0 0.7152414736502382 2 Q96IZ0 1 +Polynucleotide adenylyltransferase activity 0.7921708185053411 1.103280877672537 0.2699052081578452 1.0 0.715488362453933 2 P51003 1 +Proline rich region binding 0.7537308678678236 1.102015316135217 0.2704550130394918 1.0 0.7155345226871594 4 Q9UQB8 1 +Phosphatase regulator activity 0.4506397955960716 1.0872243225962013 0.2769376841271582 1.0 0.7255443420407421 19 P78318,Q01105,Q12972,P30153,Q86XL3,Q5H9R7,P17931,P30154 8 +S adenosyl l methionine binding 0.7875444839857639 1.0845610810662514 0.2781161001951682 1.0 0.7258020168200117 2 Q99873 1 +Peptidase regulator activity 0.396166948422422 1.0821040112112574 0.2792063136556919 1.0 0.726057989986851 29 P30086 1 +Growth factor receptor binding 0.4872507362306469 1.080690410188191 0.2798348503074321 1.0 0.726057989986851 13 Q9H2J4,Q8WXW3,Q92542,Q9NZ08,Q92990 5 +Glutathione transferase activity 0.5989988450388869 1.0788105068670792 0.2806722100473879 1.0 0.7268274572325422 6 P78417 1 +Pre mrna intronic binding 0.6532546871148637 1.075866433429185 0.2819869958455612 1.0 0.728827927723912 5 Q9BWF3,P22626,P14866 3 +Protein carboxyl o methyltransferase activity 0.8339756110480517 1.066398908301983 0.2862433549865419 1.0 0.7369943852527058 3 O60725 1 +Lipopolysaccharide binding 0.5668004754187741 1.064856147118723 0.2869410323130799 1.0 0.7373781021582779 7 Q8WTV0 1 +Dioxygenase activity 0.4683178585064466 1.059056701415245 0.2895739574499734 1.0 0.7420507839543484 15 Q32P28,O00625,P29375,P13674 4 +Nf kappab binding 0.4834410107415671 1.0584209169332683 0.2898635874821673 1.0 0.7420507839543484 13 Q99829,P60900,O43823 3 +Protein arginine omega n asymmetric methyltransferase activity 0.8280561552844828 1.0449911455573442 0.2960270618756977 1.0 0.7445435941819989 3 Q86X55 1 +Protein kinase b binding 0.7761565836298898 1.03865188184011 0.2989666673675741 1.0 0.7445435941819989 2 Q9UKG1 1 +5 3 exonuclease activity 0.5475118882547781 1.0358906516499249 0.3002531593653592 1.0 0.7445435941819989 8 Q8IV08 1 +Translation repressor activity mrna regulatory element binding 0.5884982668038314 1.0320703509497464 0.3020391620537221 1.0 0.7458318139136786 6 P34897,Q9BPZ3,P00374 3 +Ferrous iron binding 0.7743772241992852 1.0315023944248656 0.302305285946822 1.0 0.7458318139136786 2 Q9C0B1 1 +Aminopeptidase activity 0.4782877645132131 1.02831714528139 0.303800668579937 1.0 0.7458318139136786 13 Q9UIQ6,P55786,P09960,Q6P179 4 +Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen 0.8234247063011888 1.028274889477666 0.3038205394334063 1.0 0.7458318139136786 3 Q15800,Q16850 2 +Deoxyribonuclease activity 0.4632970606784715 1.0280848531385154 0.3039099149727955 1.0 0.7458318139136786 15 Q8IV08,Q9UQ84 2 +Hexosyltransferase activity 0.3885253435239832 1.0252374746330413 0.3052511499861186 1.0 0.7458318139136786 30 Q86SF2,P04844,Q10472,P35573,O43505,Q13126,P06865,P04062,P13807 9 +Atpase coupled ion transmembrane transporter activity 0.5451022905658915 1.0241406505914683 0.3057688463291941 1.0 0.7458318139136786 8 P21283,P61421,P36543 3 +Pyrophosphate hydrolysis driven proton transmembrane transporter activity 0.5451022905658915 1.0241406505914683 0.3057688463291941 1.0 0.7458318139136786 8 P21283,P61421,P36543 3 +Active ion transmembrane transporter activity 0.3800549890076552 1.0157445113950967 0.3097510657692481 1.0 0.747395831492511 36 Q9HD20,Q96ES6,P36543 3 +Transition metal ion binding 0.3471437842255824 1.0145870108684567 0.31030273361073 1.0 0.747395831492511 167 Q99829,Q9NRW3,P55786,P29375,O75976,Q6P179,Q03164,Q9UIQ6,Q15800,Q5JRX3,Q8N4Q0,O75312,P13674,P09960,Q9C0B1,O60888,Q8TEY7,P49356,Q9BU89,Q9NZ08,O43823,Q92696,P31350,P51003,O15344,Q16850,Q9NUD5,Q5JTZ9,Q5VT66,Q8NCC3,P42892,Q9BWF3,Q32P28,Q8NB78,Q06481,Q15437,P19474 37 +L ascorbic acid binding 0.6375539632495049 1.0110580763347714 0.3119886342110143 1.0 0.7496504573289039 5 Q32P28 1 +Cytokine activity 0.6371722528176932 1.0094855468214914 0.3127418297240987 1.0 0.7496504573289039 5 P43490 1 +Protein arginine n methyltransferase activity 0.7288745758232646 1.0074654158567469 0.3137111691878633 1.0 0.7496504573289039 4 Q99873,Q86X55 2 +Primary active transmembrane transporter activity 0.3685063353843847 0.9962868141835672 0.3191108086113874 1.0 0.7590883659711587 45 Q9HD20,O43676,O75306,P08183,P47985,P36543 6 +Sh2 domain binding 0.579100768025021 0.990317156691524 0.322019123288443 1.0 0.7633045885355687 6 Q13501,Q07666 2 +Cytoskeletal anchor activity 0.6304495168813569 0.9818188729984444 0.3261890886274297 1.0 0.7659941726642319 5 Q8TD16,Q9UQB8 2 +Acid phosphatase activity 0.8103199635820233 0.981153774354519 0.3265169157195711 1.0 0.7659941726642319 3 P11117 1 +Histone lysine n methyltransferase activity 0.5061023819942425 0.9771682985181837 0.3284858396482084 1.0 0.7659941726642319 10 Q9BYW2,Q03164,O96028 3 +Lysine n methyltransferase activity 0.5061023819942425 0.9771682985181837 0.3284858396482084 1.0 0.7659941726642319 10 Q9BYW2,Q03164,O96028 3 +Misfolded protein binding 0.4687277509859131 0.9725568424377916 0.3307736009625612 1.0 0.7659941726642319 13 P46379,P48723 2 +Mitogen activated protein kinase p38 binding 0.8066927732289084 0.9681624172451276 0.3329632612911146 1.0 0.7675859745716261 3 Q15750,Q99873 2 +Phosphatidylinositol binding 0.365470085099688 0.9521726949389016 0.3410094063947837 1.0 0.7784761316051706 44 Q8WTV0,Q92783,O14964,Q9BZF1,P35080,Q06481,Q9UKG1,P07737,O60443 9 +2 oxoglutarate dependent dioxygenase activity 0.4752730077907963 0.9518707588651882 0.3411625308894683 1.0 0.7784761316051706 12 Q32P28,P29375,P13674 3 +Phosphatidylethanolamine binding 0.7129967009567607 0.947486974436778 0.3433906905267827 1.0 0.7822323526576204 4 P30086 1 +Poly g binding 0.6207510285711958 0.9420155931071964 0.3461846566391753 1.0 0.7826957728841301 5 O14979 1 +Minor groove of adenine thymine rich dna binding 0.618925382474532 0.9345394987725484 0.3500256710453202 1.0 0.7862356718645326 5 Q03164 1 +Oxidoreductase activity acting on the ch nh2 group of donors 0.748754448398583 0.9294008411887268 0.3526813920396341 1.0 0.7886168307322384 2 P23378 1 +2 acylglycerol 3 phosphate o acyltransferase activity 0.795634092942147 0.9287075528711 0.3530406654723235 1.0 0.7886168307322384 3 Q8NF37 1 +Endopeptidase activator activity 0.6143834242814128 0.9159651767430812 0.3596851598218757 1.0 0.7924866472141 5 Q9UL46,P61289 2 +Passive transmembrane transporter activity 0.3761158557654391 0.9099795847578636 0.3628332763940602 1.0 0.7929234528026293 28 P45880,P21796,Q9C0H2 3 +Nedd8 specific protease activity 0.7892488430046359 0.9060410458278556 0.3649141274929111 1.0 0.7961762781663515 3 Q96FW1,Q9BT78 2 +Translation activator activity 0.7015669515669398 0.9045797313635912 0.3656880771346356 1.0 0.7965717595931122 4 Q9H074,P11940,Q6PKG0 3 +Ubiquitin like protein conjugating enzyme binding 0.4858488762138527 0.8709607915751091 0.3837755617793821 1.0 0.8218724113295286 10 Q9Y679,Q96GG9,Q9UBS8 3 +7sk snrna binding 0.6902427603086074 0.8623357606061277 0.3885027795112954 1.0 0.8218724113295286 4 Q4G0J3,O94992 2 +Ubiquitination like modification dependent protein binding 0.6877998879540861 0.8532618176004335 0.3935141291105115 1.0 0.8236364292225152 4 Q99543 1 +Ether hydrolase activity 0.5980571715901967 0.8495403825468189 0.3955806695688955 1.0 0.8236364292225152 5 P07099 1 +Epoxide hydrolase activity 0.5980571715901967 0.8495403825468189 0.3955806695688955 1.0 0.8236364292225152 5 P07099 1 +S adenosylmethionine dependent methyltransferase activity 0.360776343922903 0.8457755042245981 0.3976779931133478 1.0 0.8256810561113376 37 Q9BYW2,Q9H993,O60725,P21964,O96028,Q08J23,Q86X55,Q03164 8 +Protein kinase a regulatory subunit binding 0.5166481481026938 0.82994498523044 0.4065698891098606 1.0 0.8308749385950776 7 Q9ULX6 1 +Mhc protein binding 0.5038586999568944 0.8242509126426507 0.4097970037860481 1.0 0.8308749385950776 8 Q9NUQ9,P07437 2 +Nucleotide transmembrane transporter activity 0.5026213440667062 0.8183092796198697 0.4131806087065235 1.0 0.8308749385950776 8 Q9H2D1 1 +Organophosphate ester transmembrane transporter activity 0.5026213440667062 0.8183092796198697 0.4131806087065235 1.0 0.8308749385950776 8 Q9H2D1 1 +Proteoglycan binding 0.676107903955757 0.8100459364851983 0.4179137748002195 1.0 0.8345856067332763 4 Q07954,P07858 2 +Cysteine type endopeptidase activity 0.3945284954463249 0.8022420948179082 0.4224129307200175 1.0 0.836730993706782 21 Q8TEY7,Q96RU2,P40818,O43292,Q96K76,Q9UPU5,P07858 7 +Dna directed dna polymerase activity 0.5355225519807633 0.798533484278666 0.4245609699142307 1.0 0.8368079472631689 6 Q9Y2S7,Q9NR33 2 +Glycosyltransferase activity 0.3501981792631073 0.7927151394922575 0.4279438076606876 1.0 0.8368079472631689 43 Q13126,P43490,P04062,O43505 4 +Transferase activity transferring one carbon groups 0.3358689421205361 0.7925519793250391 0.4280388960627102 1.0 0.8368079472631689 52 Q9BYW2,Q9H993,O60725,P21964,O96028,Q08J23,Q86X55,Q8N6R0,Q03164,Q9BV86 10 +Cytokine receptor binding 0.4120986848776644 0.7898038996342682 0.4296423012939154 1.0 0.8368079472631689 18 Q9H2J4,Q8WXW3,P14174,Q9NZ08,Q9NXR7,P62942,P62993 7 +Aspartic type peptidase activity 0.7551836010014867 0.7868394367516682 0.4313758643247536 1.0 0.8368079472631689 3 Q8TCT9 1 +Oxidoreductase activity acting on other nitrogenous compounds as donors 0.5319322778569326 0.7829350359851899 0.4336652619453744 1.0 0.8368079472631689 6 O43169 1 +G protein coupled receptor activity 0.7532862704527625 0.7802990912790744 0.4352148475721391 1.0 0.8368079472631689 3 Q6RW13 1 +Transcription coregulator binding 0.3909075871216446 0.7766775254221674 0.4373490497686831 1.0 0.8397101755558716 21 Q15369,Q13363,Q00059,Q9UQB8 4 +Protein lipid complex binding 0.6662213308723247 0.7738070026483415 0.4390449308041662 1.0 0.8417637475047066 4 Q8WTV0 1 +Phosphatidylinositol phosphate phosphatase activity 0.6617394758927029 0.757480260470479 0.4487621875812824 1.0 0.8460155388915335 4 Q9Y217 1 +Quinone binding 0.6613785302005979 0.756168293731449 0.4495482999471609 1.0 0.8460155388915335 4 O75306 1 +Kinase activator activity 0.4472335802891409 0.7479458327415196 0.4544928306894749 1.0 0.8483866172870198 11 Q15750,Q7L7X3 2 +Ribosomal large subunit binding 0.6583208201287499 0.7450720021333818 0.4562281935960972 1.0 0.8498442163158199 4 Q9NTK5 1 +High density lipoprotein particle binding 0.7423581201986648 0.742864247873828 0.4575638730249936 1.0 0.8498442163158199 3 Q8WTV0 1 +Nucleobase containing compound transmembrane transporter activity 0.4608612314955685 0.7414257931427538 0.4584353101406022 1.0 0.8498442163158199 10 Q9H2D1,Q8TB61 2 +Oxidoreductase activity acting on other nitrogenous compounds as donors cytochrome as acceptor 0.7402854861798636 0.7358118490615223 0.4618452091895524 1.0 0.85381012537931 3 O43169 1 +Histone arginine n methyltransferase activity 0.7386970452118263 0.7304176910327651 0.4651349078729045 1.0 0.8587105991499777 3 Q99873,Q86X55 2 +Oxidoreductase activity acting on ch or ch2 groups 0.6939501779359494 0.718489112251405 0.4724557587686988 1.0 0.8674597538048242 2 P31350 1 +Immunoglobulin binding 0.733757642626018 0.7137050068196459 0.4754096097552707 1.0 0.8693204292667807 3 P55899 1 +N acetyltransferase activity 0.4075883208141451 0.674741959162049 0.499839721433158 1.0 0.8969086590202462 14 Q86UY6 1 +Phosphatidylinositol bisphosphate phosphatase activity 0.7192888257046421 0.6653136751594345 0.505849885675492 1.0 0.8975776055360302 3 Q9Y217 1 +Histone h3 methyl lysine 4 demethylase activity 0.7177556825751301 0.6602383775311184 0.5091008679343458 1.0 0.8975776055360302 3 Q8NB78 1 +Acetylglucosaminyltransferase activity 0.5495308258366695 0.6567151986144293 0.5113640599148921 1.0 0.8975776055360302 5 O43505 1 +Profilin binding 0.631760672972365 0.6501848114550128 0.5155728507989696 1.0 0.8975776055360302 4 P42858 1 +Wd40 repeat domain binding 0.6269566188659687 0.6333443146391023 0.5265088205212511 1.0 0.9067161275095116 4 Q96K76 1 +Branched chain amino acid transmembrane transporter activity 0.6697508896797297 0.6299757797074845 0.528710430865043 1.0 0.9075182874618364 2 Q01650 1 +L leucine transmembrane transporter activity 0.6697508896797297 0.6299757797074845 0.528710430865043 1.0 0.9075182874618364 2 Q01650 1 +4 iron 4 sulfur cluster binding 0.3939766958651321 0.6256805259350571 0.5315245090037348 1.0 0.9095161169567209 16 P21912,Q9H9T3,Q07864,P18074,Q5VV42,Q16134,O75306,Q06203,P21399 9 +Lys48 specific deubiquitinase activity 0.6242877492877502 0.6240361324442157 0.5326038560057962 1.0 0.9095161169567209 4 Q93008,Q93009,Q9H8M7 3 +Alpha glucosidase activity 0.7004610692740041 0.6037474794208721 0.546011542353182 1.0 0.9197981801718986 3 P10253 1 +Beta tubulin binding 0.3863779818253898 0.5999451633679986 0.5485427819311957 1.0 0.9197981801718986 17 Q9UKG1,O14737,P42858,Q7L7X3 4 +Type i transforming growth factor beta receptor binding 0.6988099747776402 0.598431522450097 0.549552037706871 1.0 0.9197981801718986 3 P62942 1 +Transforming growth factor beta receptor binding 0.6988099747776402 0.598431522450097 0.549552037706871 1.0 0.9197981801718986 3 P62942 1 +Protein serine threonine kinase inhibitor activity 0.4643030514598573 0.5923745851121659 0.553599781124372 1.0 0.9198113580612204 7 P10644,P04792,O94992 3 +Acetyltransferase activity 0.3344789149924299 0.5787679392101815 0.5627457668949161 1.0 0.9229898422939378 25 Q86UY6,Q969G3,Q9BWD1 3 +Protease binding 0.3553009948175417 0.5756162539663567 0.5648745921858769 1.0 0.923602490122944 22 P07602,P46379 2 +C4 dicarboxylate transmembrane transporter activity 0.528321931500815 0.5756054741515669 0.5648818801198363 1.0 0.923602490122944 5 Q9UBX3 1 +C acyltransferase activity 0.4379506723391334 0.5624471155564985 0.5738114256238935 1.0 0.9291597060704976 9 Q9BWD1 1 +Hydrolase activity acting on ester bonds 0.3093767485468723 0.5553595468509638 0.5786487565361189 1.0 0.931918562357804 143 Q5RKV6,Q96B26,Q8N2A8,O00584,Q969T7,Q9NPH0,Q9BQP7,Q9UMR5,Q8NHP8,P50897,Q12972,Q8IV08,P09601,Q5JTZ9,P11117,Q15750,Q8NCC3,Q9NUJ1,P35790,Q06124,Q9Y217,Q15165,Q9H993,Q5TFE4,Q9UQ84,Q96C86 26 +Gpi anchor binding 0.6480427046263374 0.5537871680682416 0.579724511161634 1.0 0.931918562357804 2 O43292 1 +Lamin binding 0.4441348532847019 0.5448942183394992 0.5858262729391623 1.0 0.9362857805157302 8 Q5SNT2,Q14739,Q9ULX6 3 +Phosphoprotein binding 0.3572128402940812 0.5441516507734352 0.5863371198115586 1.0 0.9362857805157302 21 O15344,P29372,P11717,Q8IWS0,P07737,P62993,P46109,P42345,Q06124 9 +Heparin binding 0.4008413628069776 0.5427985140541146 0.587268536439554 1.0 0.9362857805157302 12 Q06481,O14737,Q13685,P30533,O43670 5 +Cyclin dependent protein serine threonine kinase regulator activity 0.5188247651907797 0.5401214818966247 0.5891132568898689 1.0 0.9381140014928718 5 P11802,O94992 2 +Clathrin heavy chain binding 0.5177593086622182 0.5361765925859623 0.5918365092573727 1.0 0.9391124774993022 5 Q5VW38 1 +Ribosome binding 0.3249788580853902 0.5261869365281465 0.5987583296146055 1.0 0.9443344571937916 35 Q9NTK5,Q06787,P46379,Q9UHB9,Q99543,Q9BRP8 6 +Disulfide oxidoreductase activity 0.3478926152982142 0.524408350969676 0.5999945493998446 1.0 0.9443344571937916 22 O95881 1 +Protein tyrosine phosphatase activity 0.4292097719457541 0.5215212803728674 0.6020036851399424 1.0 0.9443344571937916 9 Q9Y217,Q06124 2 +Protein demethylase activity 0.4664965727521903 0.5086810723442742 0.6109757916614158 1.0 0.9464542813740766 6 Q8NB78 1 +N methyltransferase activity 0.3454536638192507 0.5077301783249127 0.6116425813959743 1.0 0.9464542813740766 22 Q9BYW2,O96028,Q9H7B4,Q86X55,Q03164 5 +Protein kinase a binding 0.385573328204066 0.5035225067971506 0.6145969605024082 1.0 0.9464542813740766 13 Q9ULX6 1 +Nitrite reductase activity 0.5863825922878065 0.4960355656345169 0.6198693183781101 1.0 0.9464542813740766 4 O43169 1 +Intramolecular oxidoreductase activity transposing c c bonds 0.5067112687994402 0.4957296025364426 0.6200851985245233 1.0 0.9464542813740766 5 P42126 1 +Aromatic amino acid transmembrane transporter activity 0.6645419866141284 0.4915699486395142 0.6230233919888906 1.0 0.9464542813740766 3 Q01650 1 +Co smad binding 0.6284697508896759 0.4881722104193806 0.6254278666062425 1.0 0.9464542813740766 2 Q93008 1 +Mitochondrial ribosome binding 0.6625133499466074 0.4854705929149231 0.6273425677430351 1.0 0.9464542813740766 3 Q07021,Q15070 2 +Thiol oxidase activity 0.6618013527945972 0.4833363984089201 0.6288568997522697 1.0 0.9464542813740766 3 Q6ZRP7,P07237 2 +Spectrin binding 0.5005384977968246 0.4735170838007528 0.6358443156380322 1.0 0.9484736517397506 5 Q13561,Q12955 2 +Mitogen activated protein kinase binding 0.4560898375238603 0.4675384967721228 0.6401146560432784 1.0 0.9506233124001836 6 Q15750,Q99873 2 +Sequence specific mrna binding 0.4241186979691509 0.4563982769240253 0.648103604582392 1.0 0.958435454936084 8 P00374 1 +Protein serine threonine kinase activator activity 0.4320812432375568 0.4541241886648181 0.6497394443443765 1.0 0.9585618147078396 7 Q7L7X3 1 +Oxidoreduction driven active transmembrane transporter activity 0.3183708970312983 0.4508558961889177 0.6520934121777211 1.0 0.959927213545298 27 O75306,P47985,O43676 3 +Mrna 3 utr au rich region binding 0.381395951254552 0.4428215376954797 0.6578948235747057 1.0 0.9639374694944024 12 Q14103,Q92945,Q96B26,P31483 4 +Phosphatidylinositol 4 5 bisphosphate binding 0.4001024013484298 0.441227914033966 0.6590480067402626 1.0 0.9639374694944024 10 O60443,P35080 2 +Ubiquitin like protein ligase binding 0.2777779667563389 0.4396762310690063 0.6601716200683496 1.0 0.9639374694944024 97 Q96FW1,Q9NQC3,Q5VTR2,Q9Y3I1,O75477,P10644,Q13564,P25788,P11233,Q92990,P46379,O76024,P29372,Q8TCT9,O15344,Q92783,Q8N0X7,P08183,Q9HB71,Q13501,Q9Y679,O14964,Q9UJX6,O75306,P07437 25 +Cadherin binding involved in cell cell adhesion 0.3978462625219289 0.4307109443381145 0.6666785600261671 1.0 0.9639374694944024 10 P04083,Q9UQB8 2 +Phospholipid transporter activity 0.4209818324015658 0.4085878264059813 0.682842165908909 1.0 0.9733108931017792 7 P08183 1 +Insulin like growth factor receptor binding 0.6032028469750838 0.4084942618823172 0.6829108424069776 1.0 0.9733108931017792 2 P61981 1 +Apolipoprotein binding 0.5576605900944382 0.4053695900090955 0.6852058606415656 1.0 0.9734848590933024 4 Q8WTV0 1 +Structural constituent of eye lens 0.6301433147580694 0.3921167459803793 0.6949719548167577 1.0 0.9789412766070704 3 P08670 1 +Signaling adaptor activity 0.3629144930227701 0.3863994332371385 0.6992008698060657 1.0 0.9789412766070704 13 Q02750,Q07666,Q06124 3 +Glucosyltransferase activity 0.4073823944745478 0.3853580640662108 0.6999721479310972 1.0 0.9789412766070704 8 P04062 1 +Phosphatidylinositol bisphosphate binding 0.3621203302910795 0.3824304429188065 0.7021421131561665 1.0 0.9791272787529708 13 O60443,P07737,P35080 3 +Eukaryotic initiation factor 4e binding 0.625133499465999 0.3783893815032418 0.7051413551824339 1.0 0.9791272787529708 3 Q04637,Q6PKG0 2 +Nadh dehydrogenase activity 0.3424263172000657 0.3783040108166053 0.7052047662446992 1.0 0.9791272787529708 19 O75306,O43676 2 +Dna polymerase activity 0.4026078488469375 0.3656665055813353 0.7146139423654361 1.0 0.9862711571379154 8 Q9Y2S7,Q9NR33 2 +Glycosaminoglycan binding 0.3470444271458418 0.3577669044985657 0.7205177597876502 1.0 0.9862711571379154 16 O14737,Q06481 2 +Phosphoric ester hydrolase activity 0.2896354404637341 0.354006112657765 0.723334302263666 1.0 0.9873319264397256 54 Q8N2A8,Q9Y217,Q969T7,Q9H993,Q8IV08,Q5TFE4,Q9NPH0,P09601,P11117,Q15750,Q06124 11 +2 iron 2 sulfur cluster binding 0.390542381558391 0.3493506203403378 0.7268260998990486 1.0 0.9882623888788928 9 P21912 1 +Dynactin binding 0.4604119099498905 0.33711770248329 0.7360281730866771 1.0 0.9886008284949392 5 Q9Y5X3,Q8TD16,P42858 3 +Trna methyltransferase activity 0.4602619923850205 0.3366374785148659 0.7363901997914906 1.0 0.9886008284949392 5 Q08J23 1 +Intramolecular oxidoreductase activity 0.3300017330501796 0.3351824128118277 0.7374874880094167 1.0 0.9886008284949392 20 P42126,Q9H7Z7 2 +Actin monomer binding 0.5326642722318344 0.3319790221750196 0.7399050994450309 1.0 0.9886008284949392 4 P35080 1 +Calcium dependent phospholipid binding 0.3757225641127629 0.3309892068267409 0.7406526382080316 1.0 0.9886008284949392 10 Q99829,P50995,P04083 3 +Mrna binding 0.3017508483081344 0.3268651674817898 0.7437698675464857 1.0 0.9886008284949392 166 Q96B26,P16989,O75153,P51116,P38159,Q13310,P35637,P22626,P11940,Q92945,Q14671,P31483,P51114,Q07666,Q92804,O60506,Q12972,Q96PU8,P52756,Q71RC2,P61978,O43390,Q99729,Q9BPZ3,Q9BWF3,Q14011,Q14103,P67809,Q06787,P62995,P00374,O75525,Q96I24,Q96PK6 34 +Metal cluster binding 0.2994489099977888 0.3237599228114002 0.7461198002083151 1.0 0.9886008284949392 25 P21912,Q06203,Q07864,P18074,Q5VV42,Q16134,O75306,P47985,Q9H9T3,P22830,P21399 11 +Methyl cpg binding 0.3734271892462525 0.3210341745561384 0.748184492947938 1.0 0.9886008284949392 10 O95983,Q9UFC0 2 +P type calcium transporter activity 0.5683274021352241 0.3093738918385945 0.7570371281820751 1.0 0.989745039179678 2 P16615 1 +G protein beta subunit binding 0.567259786476861 0.3065588655084227 0.7591791674802937 1.0 0.9904422307357736 2 P48643 1 +Centromeric dna binding 0.5945140553267987 0.2992093316578458 0.7647803296365496 1.0 0.992147454663632 3 Q99661 1 +Chaperone binding 0.2962977171994904 0.2908090390872804 0.7711973717939207 1.0 0.9966242958567588 37 Q16543,O43615,O60884,P02786,O14976,P01889,O15212,Q14108,Q8WXX5,P53634,Q9NQP4 11 +Endoribonuclease activity producing 5 phosphomonoesters 0.346647441664245 0.2772735602221127 0.7815700598342383 1.0 1.0 12 Q9UQ84 1 +Kinase regulator activity 0.2942244466715947 0.2747070005453503 0.7835413523585217 1.0 1.0 39 Q16543,Q02750,P04792,O94992,Q15750,P10644,O95684,Q7L7X3 8 +Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters 0.3391715796419253 0.2725470611054011 0.7852014107473848 1.0 1.0 13 Q9UQ84 1 +Palmitoyltransferase activity 0.5084355342423003 0.2665651073153781 0.7898040240837305 1.0 1.0 4 O15270 1 +Ubiquitin ligase substrate adaptor activity 0.5080669377460719 0.2656172930096477 0.7905339659912307 1.0 1.0 4 Q9Y3I1 1 +K63 linked polyubiquitin modification dependent protein binding 0.5800339706442215 0.2648057799959 0.7911590840124012 1.0 1.0 3 Q13501 1 +Adenylate cyclase binding 0.5494661921708102 0.2616994060433473 0.7935531984877473 1.0 1.0 2 Q01518 1 +Endoribonuclease activity 0.3211812793825686 0.2576348745552956 0.7966887120450741 1.0 1.0 19 Q8N2A8,Q9UQ84 2 +Fibroblast growth factor binding 0.50410877977888 0.2555325804916385 0.7983117830397752 1.0 1.0 4 Q92896 1 +Rna 7 methylguanosine cap binding 0.3969589456983156 0.254385934373679 0.7991974163782993 1.0 1.0 6 Q7L576,Q96C86 2 +Nucleobase containing compound kinase activity 0.3274152296845914 0.2502256243026813 0.8024128701080582 1.0 1.0 14 Q5KU26,Q14168,O14936 3 +Exonuclease activity 0.2911410007497856 0.2482395950269538 0.8039490324997931 1.0 1.0 33 Q96B26,Q8IV08,Q9BQP7,Q9UQ84,Q96C86 5 +Cyclic nucleotide dependent protein kinase activity 0.5694905111416164 0.2410723210904063 0.8094990647820619 1.0 1.0 3 Q13131 1 +Camp dependent protein kinase activity 0.5694905111416164 0.2410723210904063 0.8094990647820619 1.0 1.0 3 Q13131 1 +Histone deacetylase binding 0.2893874275614225 0.2380683990105792 0.8118280440962162 1.0 1.0 29 Q14103,Q92769,Q8IWS0,Q9ULX6,O43823 5 +Alpha tubulin binding 0.3626358563678621 0.2370818068836766 0.8125933260653786 1.0 1.0 9 Q7L7X3 1 +Structural constituent of nuclear pore 0.3159010348453915 0.229398202511959 0.8185594331058099 1.0 1.0 19 P57740,Q9BW27,Q9BTX1,Q12769 4 +Cell cell adhesion mediator activity 0.3207706082350604 0.2249035028725557 0.8220543442047856 1.0 1.0 16 P62136,Q14126,P35613,P04083,Q9UQB8 5 +Smad binding 0.3282703785265413 0.2240417982927095 0.8227247794556833 1.0 1.0 13 Q9H6Z4,Q9UNE7,P35222,P17844,P52926,O95373,Q93008,P62942,Q9UPN9,Q96AC1,Q00577 11 +Histone binding 0.2711031426161348 0.2011663976217531 0.8405684651852343 1.0 1.0 78 O14646,Q01105,Q5VTR2,Q99733,P29375,Q7Z4V5,Q9UFC0,Q96P70,Q03164,P39687,Q15022,Q12888,Q8WXX5,Q9NWY4,Q8IXK0,Q8IWS0,Q6PL18,Q92688,P83916,Q86X55,Q99543,Q06787,P52701,Q8NB78,P55209,P49321 26 +3 5 dna helicase activity 0.3584165477888708 0.1984292820441312 0.8427092091512147 1.0 1.0 8 Q14566,Q8N3C0,P46063,P19447,P49736,P33992,Q08211 7 +Oxidoreductase activity 0.3013163775149572 0.1875996377536918 0.851190510232859 1.0 1.0 210 Q96CU9,O75874,Q15392,Q14914,P29375,O15254,Q15800,Q9BY49,Q8N4Q0,P30519,P13674,O43676,Q9UHG3,P48735,O95881,P21912,Q16850,P78417,P09601,Q32P28,Q14739,Q8NB78,Q06136,O75306,P47985,P00374,Q8NBX0,Q9Y6M9,Q9H7Z7,O43169 30 +Tpr domain binding 0.4647435897435894 0.1650526491350534 0.8689025422626826 1.0 1.0 4 O76094,P07900,P08238 3 +Nucleotidase activity 0.3656584980372312 0.1601751710177473 0.872743087508042 1.0 1.0 6 Q969T7 1 +Thioesterase binding 0.5007117437722308 0.1598730347828042 0.8729810903968944 1.0 1.0 2 P60953 1 +Phosphatidylinositol phosphate binding 0.2736554064270254 0.158252147268465 0.8742581138393313 1.0 1.0 25 O60443,P35080,Q9BZF1,P07737 4 +Nitric oxide synthase regulator activity 0.4975088967971417 0.1543038422825393 0.8773701678979164 1.0 1.0 2 P07900 1 +Heat shock protein binding 0.27578426222642 0.1541187831013949 0.877516078446569 1.0 1.0 47 Q16543,O60884,Q92769,P42858,P46379,Q12907,Q99543,Q00059,P48723 9 +Nucleoside triphosphatase regulator activity 0.2681307153160653 0.1435882254374499 0.8858256390400436 1.0 1.0 73 P55010,P80303,O43924,A4D1U4 4 +Cell adhesion mediator activity 0.2996973745904221 0.1392209966937759 0.889275517114618 1.0 1.0 18 P62136,Q14126,P35613,P04083,Q9UQB8 5 +Chemoattractant activity 0.4513275275237514 0.1385228343749098 0.8898272243568 1.0 1.0 4 P14174 1 +Nucleoside monophosphate kinase activity 0.3382979557270261 0.1331004407134146 0.8941139466098424 1.0 1.0 8 O14936 1 +Peptidase activator activity 0.315043568695024 0.1283568946260685 0.897866542017334 1.0 1.0 11 P53634,Q9UL46,P61289 3 +Metallocarboxypeptidase activity 0.4398511078280775 0.1176386377600618 0.906353988984026 1.0 1.0 4 O75976 1 +Mhc class i protein binding 0.3367971640518833 0.1163471236494438 0.9073774399031298 1.0 1.0 7 P07437 1 +Fatty acid binding 0.3320387615189038 0.1143753891158613 0.9089402225918496 1.0 1.0 8 O15254,P29375 2 +Nad binding 0.2687563975198644 0.1114628192190409 0.9112493477973008 1.0 1.0 28 P48735,O75306 2 +Flavin adenine dinucleotide binding 0.2673630403021058 0.1087875811790851 0.9133709741375252 1.0 1.0 27 Q8NB78,Q15392,O95831,Q15067,Q16134,O00116,O15254,Q709F0,Q14534 9 +E box binding 0.49234603061587 0.1038793870274844 0.9172650653646012 1.0 1.0 3 O14744,Q13547 2 +Phosphotransferase activity phosphate group as acceptor 0.3227748760552569 0.1006396060155709 0.9198365552448556 1.0 1.0 9 O14936 1 +Fk506 binding 0.3407762053167473 0.0967686019622963 0.9229101588860128 1.0 1.0 6 P62942 1 +Macrolide binding 0.3407762053167473 0.0967686019622963 0.9229101588860128 1.0 1.0 6 P62942 1 +Phosphatidylinositol phosphate 4 phosphatase activity 0.4544483985765098 0.0926913097632072 0.9261488010928792 1.0 1.0 2 Q9NTJ5 1 +Retromer complex binding 0.3630290226060576 0.0861312389041105 0.931362090836344 1.0 1.0 5 P11717 1 +Oxidized dna binding 0.3619522622016359 0.0841295913354277 0.9329533975538368 1.0 1.0 5 P43246,P23396,P52701,P18887 4 +Nadplus binding 0.3347134175270628 0.0829816221576033 0.9338661526018308 1.0 1.0 6 Q8IXJ6,Q16836 2 +Rna polymerase ii ctd heptapeptide repeat kinase activity 0.3612397577484812 0.0828150370775912 0.9339986123417584 1.0 1.0 5 P06493,Q9NYV4,P11802,Q14004 4 +Hydroxymethyl formyl and related transferase activity 0.4738341046635781 0.0807242651925701 0.9356612389554868 1.0 1.0 3 P34897,P22102 2 +Structural constituent of synapse 0.4164209668319067 0.0802288119325515 0.9360552754067684 1.0 1.0 4 Q8IUD2 1 +Mitochondrion targeting sequence binding 0.4391459074733075 0.0764597822315209 0.9390533094029848 1.0 1.0 2 Q15388 1 +Rdna binding 0.4686188508144501 0.0748615846481983 0.940324841763048 1.0 1.0 3 P42345 1 +Insulin binding 0.4373665480427026 0.0747513888053093 0.9404125196579728 1.0 1.0 2 P14735 1 +Pseudouridine synthase activity 0.4676213632357175 0.0737726551421019 0.9411912857543454 1.0 1.0 3 Q96PZ0 1 +Oxidoreductase activity acting on the ch ch group of donors oxygen as acceptor 0.4040824790077435 0.0633264847196469 0.9495065263277388 1.0 1.0 4 O15254 1 +Calcium dependent protein binding 0.2811614941332263 0.0609981575835075 0.9513606763604404 1.0 1.0 18 O76024,P50995,P04083,Q9NW64 4 +Signal recognition particle binding 0.3236231369676161 0.0594977232309625 0.9525556788650448 1.0 1.0 6 Q9UHB9 1 +Rna polymerase core enzyme binding 0.2802013305772352 0.0556881109690576 0.9555902708777412 1.0 1.0 17 Q6IA86,Q5BKZ1 2 +Protein homodimerization activity 0.2736297450561803 0.0514269661536248 0.9589852973153388 1.0 1.0 145 O75874,P51116,O43707,Q9UKG1,Q03164,O95684,O00264,P16278,Q8N2A8,P02786,Q15070,P06280,P21266,P51648,O95772,Q9NQH7,P51114,P31350,O15344,P29372,Q8TCT9,Q9NVV4,Q15067,P09601,P23378,Q14108,Q9UNH7,P42892,Q9HB71,Q8IYB8,O43252,P34897,Q06787,O00429,P07602,P52701,Q07820,Q06481,P04792,Q8IY95,P19474,Q9Y624,P22830 43 +Nad dependent protein deacetylase activity 0.3938569753390493 0.0507465656251088 0.959527470422626 1.0 1.0 4 Q92769 1 +Acetylcholine receptor binding 0.4049822064056981 0.0495981101984817 0.9604426526235004 1.0 1.0 2 O15258 1 +Structural constituent of postsynapse 0.4049822064056926 0.0495981101984786 0.9604426526235028 1.0 1.0 2 P12814 1 +Phosphatidylinositol 3 kinase binding 0.4375222499110032 0.0456021107473958 0.9636273867911388 1.0 1.0 3 O14654,P50570 2 +Anaphase promoting complex binding 0.395729537366539 0.0442806305423471 0.9646807111166223 1.0 1.0 2 Q16763 1 +Dolichyl phosphate mannose protein mannosyltransferase activity 0.3946619217081895 0.0437145791409179 0.9651319178524372 1.0 1.0 2 O60762 1 +Voltage gated chloride channel activity 0.3928825622775804 0.0427921940155541 0.9658671865645104 1.0 1.0 2 P51790 1 +L amino acid transmembrane transporter activity 0.3013476236765633 0.0412550780418506 0.9670925450867448 1.0 1.0 9 Q9Y619,Q01650 2 +P type transmembrane transporter activity 0.382478632478638 0.0382238099027663 0.9695092372080868 1.0 1.0 4 P05023,P16615,P20020 3 +P type potassium transmembrane transporter activity 0.3822064056939444 0.0377861444368013 0.969858191621283 1.0 1.0 2 P05023 1 +Histone methyltransferase binding 0.3118317890235124 0.037010160444662 0.970476904428595 1.0 1.0 6 P35222,P08238,O95785,Q13185,P83916 5 +Kinase inhibitor activity 0.2740091739921304 0.0336513675089036 0.97315516009149 1.0 1.0 17 O95684,P10644,P04792,O94992 4 +Protein disaggregase activity 0.3771367521367524 0.0328640675666301 0.9737829872357192 1.0 1.0 4 P0DMV9,Q9UN37,P11142 3 +Exonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters 0.2500489340114425 0.0311089824010371 0.975182626217756 1.0 1.0 25 Q8IV08,Q9UQ84 2 +Dynein heavy chain binding 0.3487544483985818 0.0270701096662061 0.978403815051376 1.0 1.0 2 O43237 1 +Protein deacetylase activity 0.3247870276371765 0.0260608949378355 0.9792087677794108 1.0 1.0 5 Q92769 1 +C3hc4 type ring finger domain binding 0.4001423994304035 0.0219346318301135 0.9825000992093676 1.0 1.0 3 P11142,P31689 2 +Mismatch repair complex binding 0.3997864008543959 0.0217614489530234 0.982638246177765 1.0 1.0 3 P43246,P52701 2 +Mutlalpha complex binding 0.3997864008543959 0.0217614489530234 0.982638246177765 1.0 1.0 3 P43246,P52701 2 +Acetylgalactosaminyltransferase activity 0.3963151656411804 0.0201190999195162 0.9839483636962982 1.0 1.0 3 Q86SF2 1 +Polypeptide n acetylgalactosaminyltransferase activity 0.3963151656411804 0.0201190999195162 0.9839483636962982 1.0 1.0 3 Q86SF2 1 +Mismatched dna binding 0.3618233618233592 0.019253985193402 0.9846384916121398 1.0 1.0 4 P43246,P52701,P12004 3 +Dna insertion or deletion binding 0.3618233618233592 0.019253985193402 0.9846384916121398 1.0 1.0 4 P43246,P52701,P12004 3 +Keratin filament binding 0.3832865303990925 0.0146675039191993 0.988297444685042 1.0 1.0 3 P08670 1 +Intermediate filament binding 0.3832865303990925 0.0146675039191993 0.988297444685042 1.0 1.0 3 P08670 1 +Peptidase activator activity involved in apoptotic process 0.3784264862940577 0.0129032788575179 0.9897049586947848 1.0 1.0 3 P53634,Q9BXK5 2 +Histone acetyltransferase binding 0.3135019593872438 0.0125480514338913 0.989988366221382 1.0 1.0 5 P12004,Q8IXJ6,P42224,P04637 4 +Guanyl nucleotide exchange factor activity 0.2527269748952095 0.0099885640800796 0.9920304114589856 1.0 1.0 31 P80303 1 +Chloride channel inhibitor activity 0.3645425418298386 0.0085859710275066 0.9931494704466706 1.0 1.0 3 Q9UNK0,Q9H4A3 2 +Translation regulator activity 0.2533263668991753 0.007548188456463 0.9939774741576632 1.0 1.0 75 P34897,Q9H074,P11940,Q7L576,Q06787,P51116,P27635,Q9BPZ3,P55010,Q92905,P23588,P00374,Q9Y262,P51114,Q9Y6M1,Q14011 16 +Aldehyde lyase activity 0.3061755334803964 0.0047435404490348 0.9962152165058564 1.0 1.0 5 Q9H993 1 +Dolichyl diphosphooligosaccharide protein glycotransferase activity 0.3350400289949151 0.0011637028112604 0.9990714997030956 1.0 1.0 4 P04844,P46977 2 +Carbon sulfur lyase activity 0.325026699893205 0.0009666444157352 0.9992287294650112 1.0 1.0 3 Q6YP21,Q04760 2 +Single stranded dna endodeoxyribonuclease activity 0.3340455840455854 0.0006186169677902 0.9995064151038308 1.0 1.0 4 Q92889,P49959,P18887 3 diff --git a/msigdb_gomf/selections.json b/msigdb_gomf/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..32ee10b4194afae6b6770f04b0e5d0f17edaf4e6 --- /dev/null +++ b/msigdb_gomf/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1 4 alpha oligoglucan phosphorylase activity", "1 acylglycerophosphocholine o acyltransferase activity", "1 alkyl 2 acetylglycerophosphocholine esterase activity", "1 phosphatidylinositol 3 kinase activity", "1 phosphatidylinositol 4 kinase activity", "1 phosphatidylinositol 4 phosphate 3 kinase activity", "1 phosphatidylinositol binding", "14 3 3 protein binding", "17 beta hydroxysteroid dehydrogenase nadplus activity", "17 beta hydroxysteroid dehydrogenase nadpplus activity", "2 acylglycerol 3 phosphate o acyltransferase activity", "2 acylglycerol o acyltransferase activity", "2 iron 2 sulfur cluster binding", "2 oxoglutarate dependent dioxygenase activity", "3 5 dna helicase activity", "3 5 exodeoxyribonuclease activity", "3 5 exonuclease activity", "3 beta hydroxy delta5 steroid dehydrogenase activity", "3 hydroxyacyl coa dehydratase activity", "3 hydroxyacyl coa dehydrogenase activity", "4 iron 4 sulfur cluster binding", "5 3 dna helicase activity", "5 3 exodeoxyribonuclease activity", "5 3 exonuclease activity", "5 deoxyribose 5 phosphate lyase activity", "5s rrna binding", "7s rna binding", "7sk snrna binding", "Abc type glutathione s conjugate transporter activity", "Abc type transporter activity", "Abc type xenobiotic transporter activity", "Acetyl coa c acetyltransferase activity", "Acetyl coa c acyltransferase activity", "Acetyl coa hydrolase activity", "Acetylcholine receptor binding", "Acetylgalactosaminyltransferase activity", "Acetylglucosaminyltransferase activity", "Acetyltransferase activity", "Acid amino acid ligase activity", "Acid phosphatase activity", "Acid thiol ligase activity", "Acidic amino acid transmembrane transporter activity", "Actin binding", "Actin filament binding", "Actin monomer binding", "Actinin binding", "Active ion transmembrane transporter activity", "Active transmembrane transporter activity", "Activin binding", "Acyl carnitine transmembrane transporter activity", "Acyl coa binding", "Acyl coa dehydrogenase activity", "Acyl coa oxidase activity", "Acylglycerol lipase activity", "Acylglycerol o acyltransferase activity", "Acyltransferase activity", "Acyltransferase acyl groups converted into alkyl on transfer", "Adenosine deaminase activity", "Adenyl nucleotide binding", "Adenyl nucleotide exchange factor activity", "Adenylate cyclase binding", "Adenylate kinase activity", "Adenylyltransferase activity", "Adp binding", "Adp ribose diphosphatase activity", "Adp transmembrane transporter activity", "Adrenergic receptor binding", "Alanine transmembrane transporter activity", "Alcohol binding", "Alcohol dehydrogenase activity zinc dependent", "Alcohol dehydrogenase nad p plus activity", "Alcohol dehydrogenase nadpplus activity", "Aldehyde dehydrogenase nad p plus activity", "Aldehyde lyase activity", "Alditol nadpplus 1 oxidoreductase activity", "Aldo keto reductase nadp activity", "Alkali metal ion binding", "Alpha actinin binding", "Alpha catenin binding", "Alpha glucosidase activity", "Alpha tubulin binding", "Amide binding", "Amide transmembrane transporter activity", "Amidine lyase activity", "Amino acid binding", "Amino acid cation symporter activity", "Amino acid sodium symporter activity", "Amino acid transmembrane transporter activity", "Aminoacyl trna editing activity", "Aminoacylase activity", "Aminopeptidase activity", "Aminophospholipid flippase activity", "Ammonium transmembrane transporter activity", "Amp activated protein kinase activity", "Amp binding", "Amyloid beta binding", "Anaphase promoting complex binding", "Androgen receptor binding", "Androstan 3 alpha 17 beta diol dehydrogenase activity", "Anion cation symporter activity", "Anion channel activity", "Anion sodium symporter activity", "Anion transmembrane transporter activity", "Ankyrin binding", "Annealing activity", "Antigen binding", "Antioxidant activity", "Antiporter activity", "Apolipoprotein a i binding", "Apolipoprotein binding", "Apolipoprotein receptor binding", "Arachidonate coa ligase activity", "Arginine binding", "Armadillo repeat domain binding", "Aromatic amino acid transmembrane transporter activity", "Arp2 3 complex binding", "Arrestin family protein binding", "Aryl hydrocarbon receptor binding", "Arylesterase activity", "Arylsulfatase activity", "Aspartic endopeptidase activity intramembrane cleaving", "Aspartic type endopeptidase inhibitor activity", "Aspartic type peptidase activity", "Atp dependent activity", "Atp dependent activity acting on dna", "Atp dependent activity acting on rna", "Atp dependent chromatin remodeler activity", "Atp dependent dna dna annealing activity", "Atp dependent peptidase activity", "Atp dependent protein binding", "Atp hydrolysis activity", "Atp transmembrane transporter activity", "Atpase activator activity", "Atpase binding", "Atpase coupled cation transmembrane transporter activity", "Atpase coupled inorganic anion transmembrane transporter activity", "Atpase coupled intramembrane lipid transporter activity", "Atpase coupled ion transmembrane transporter activity", "Atpase coupled lipid transmembrane transporter activity", "Atpase coupled transmembrane transporter activity", "Atpase inhibitor activity", "Atpase regulator activity", "Azole transmembrane transporter activity", "Basal transcription machinery binding", "Basic amino acid transmembrane transporter activity", "Benzodiazepine receptor activity", "Beta 1 3 galactosyltransferase activity", "Beta 2 adrenergic receptor binding", "Beta 2 microglobulin binding", "Beta catenin binding", "Beta galactosidase activity", "Beta n acetylhexosaminidase activity", "Beta tubulin binding", "Bh domain binding", "Bh3 domain binding", "Bhlh transcription factor binding", "Bile acid binding", "Biotin binding", "Box h aca snorna binding", "Branched chain amino acid transmembrane transporter activity", "Bubble dna binding", "C acetyltransferase activity", "C acyltransferase activity", "C methyltransferase activity", "C palmitoyltransferase activity", "C x c chemokine binding", "C x3 c chemokine binding", "C2h2 zinc finger domain binding", "C3hc4 type ring finger domain binding", "C4 dicarboxylate transmembrane transporter activity", "Cadherin binding", "Cadherin binding involved in cell cell adhesion", "Calcium activated cation channel activity", "Calcium cation antiporter activity", "Calcium channel inhibitor activity", "Calcium channel regulator activity", "Calcium dependent cysteine type endopeptidase activity", "Calcium dependent phospholipid binding", "Calcium dependent protein binding", "Calcium dependent protein kinase activity", "Calcium dependent protein serine threonine phosphatase activity", "Calcium independent phospholipase a2 activity", "Calcium ion binding", "Calcium ion transmembrane transporter activity", "Calmodulin binding", "Calmodulin dependent protein kinase activity", "Calmodulin dependent protein phosphatase activity", "Camp binding", "Camp dependent protein kinase activity", "Camp dependent protein kinase inhibitor activity", "Camp dependent protein kinase regulator activity", "Camp response element binding", "Carbohydrate binding", "Carbohydrate derivative transmembrane transporter activity", "Carbohydrate kinase activity", "Carbohydrate phosphatase activity", "Carbohydrate transmembrane transporter activity", "Carbon carbon lyase activity", "Carbon nitrogen ligase activity with glutamine as amido n donor", "Carbon nitrogen lyase activity", "Carbon oxygen lyase activity", "Carbon sulfur lyase activity", "Carbonyl reductase nadph activity", "Carboxy lyase activity", "Carboxylic acid binding", "Carboxylic ester hydrolase activity", "Carboxypeptidase activity", "Cardiolipin binding", "Cargo adaptor activity", "Cargo receptor activity", "Carnitine o acyltransferase activity", "Catalytic activity acting on a glycoprotein", "Catalytic activity acting on a nucleic acid", "Catalytic activity acting on a rrna", "Catalytic activity acting on a trna", "Catalytic activity acting on dna", "Catalytic activity acting on rna", "Cation cation antiporter activity", "Cation channel activity", "Cation chloride symporter activity", "Cation transmembrane transporter activity", "Ccr chemokine receptor binding", "Ccr3 chemokine receptor binding", "Ccr5 chemokine receptor binding", "Cdp alcohol phosphatidyltransferase activity", "Cell adhesion mediator activity", "Cell adhesion molecule binding", "Cell adhesive protein binding involved in bundle of his cell purkinje myocyte communication", "Cell cell adhesion mediator activity", "Cell matrix adhesion mediator activity", "Centromeric dna binding", "Ceramide binding", "Cgmp binding", "Channel inhibitor activity", "Channel regulator activity", "Chaperone binding", "Chemoattractant activity", "Chemokine binding", "Chemokine receptor binding", "Chitin binding", "Chloride channel inhibitor activity", "Chloride channel regulator activity", "Chloride ion binding", "Cholesterol binding", "Chondroitin sulfate binding", "Chromatin binding", "Chromatin dna binding", "Chromatin insulator sequence binding", "Chromo shadow domain binding", "Cis regulatory region sequence specific dna binding", "Cis trans isomerase activity", "Class i dna apurinic or apyrimidinic site endonuclease activity", "Clathrin binding", "Clathrin heavy chain binding", "Clathrin light chain binding", "Co smad binding", "Coa hydrolase activity", "Coa transferase activity", "Cobalamin binding", "Collagen binding", "Collagen binding involved in cell matrix adhesion", "Complement binding", "Complement component c1q complex binding", "Complement component c3b binding", "Copper chaperone activity", "Copper ion binding", "Core promoter sequence specific dna binding", "Coreceptor activity", "Coreceptor activity involved in wnt signaling pathway", "Coreceptor activity involved in wnt signaling pathway planar cell polarity pathway", "Cullin family protein binding", "Cuprous ion binding", "Cxcr chemokine receptor binding", "Cyclic nucleotide binding", "Cyclic nucleotide dependent protein kinase activity", "Cyclic nucleotide phosphodiesterase activity", "Cyclin binding", "Cyclin dependent protein kinase activity", "Cyclin dependent protein serine threonine kinase activator activity", "Cyclin dependent protein serine threonine kinase inhibitor activity", "Cyclin dependent protein serine threonine kinase regulator activity", "Cyclohydrolase activity", "Cyclosporin a binding", "Cysteine type endopeptidase activity", "Cysteine type endopeptidase inhibitor activity", "Cysteine type endopeptidase inhibitor activity involved in apoptotic process", "Cysteine type endopeptidase regulator activity involved in apoptotic process", "Cysteine type exopeptidase activity", "Cysteine type peptidase activity", "Cytidine deaminase activity", "Cytidylyltransferase activity", "Cytochrome b5 reductase activity acting on nad p h", "Cytokine activity", "Cytokine binding", "Cytokine receptor activity", "Cytokine receptor binding", "Cytoskeletal anchor activity", "Cytoskeletal motor activity", "Cytoskeletal protein binding", "Cytoskeleton nuclear membrane anchor activity", "D glucose transmembrane transporter activity", "D threo aldose 1 dehydrogenase activity", "D1 dopamine receptor binding", "Damaged dna binding", "Deacetylase activity", "Dead h box rna helicase binding", "Deaminase activity", "Death domain binding", "Death receptor activity", "Death receptor binding", "Dehydroascorbic acid transmembrane transporter activity", "Demethylase activity", "Deoxycytidine deaminase activity", "Deoxynucleoside kinase activity", "Deoxyribonuclease activity", "Diacylglycerol binding", "Diacylglycerol kinase activity", "Dicarboxylic acid transmembrane transporter activity", "Dihydropyrimidinase activity", "Dioxygenase activity", "Dipeptidase activity", "Dipeptidyl peptidase activity", "Diphosphotransferase activity", "Disordered domain specific binding", "Disulfide oxidoreductase activity", "Dna apurinic or apyrimidinic site endonuclease activity", "Dna binding bending", "Dna binding transcription activator activity", "Dna binding transcription factor activity", "Dna binding transcription factor binding", "Dna binding transcription repressor activity", "Dna clamp loader activity", "Dna directed dna polymerase activity", "Dna dna annealing activity", "Dna helicase activity", "Dna insertion or deletion binding", "Dna methyltransferase activity", "Dna n glycosylase activity", "Dna polymerase activity", "Dna polymerase binding", "Dna replication origin binding", "Dna secondary structure binding", "Dna topoisomerase activity", "Dna translocase activity", "Dolichyl diphosphooligosaccharide protein glycotransferase activity", "Dolichyl phosphate mannose protein mannosyltransferase activity", "Dopamine receptor binding", "Double stranded methylated dna binding", "Double stranded rna adenosine deaminase activity", "Double stranded rna binding", "Double stranded telomeric dna binding", "Dttp diphosphatase activity", "Dynactin binding", "Dynein complex binding", "Dynein heavy chain binding", "Dynein intermediate chain binding", "Dynein light intermediate chain binding", "Dystroglycan binding", "E box binding", "Efflux transmembrane transporter activity", "Electron transfer activity", "Endodeoxyribonuclease activity", "Endodeoxyribonuclease activity producing 5 phosphomonoesters", "Endonuclease activity", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 3 phosphomonoesters", "Endonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Endopeptidase activator activity", "Endopeptidase activity", "Endopeptidase regulator activity", "Endopolyphosphatase activity", "Endoribonuclease activity", "Endoribonuclease activity producing 3 phosphomonoesters", "Endoribonuclease activity producing 5 phosphomonoesters", "Enoyl coa hydratase activity", "Enzyme activator activity", "Enzyme inhibitor activity", "Enzyme regulator activity", "Ephrin receptor binding", "Epidermal growth factor receptor binding", "Epoxide hydrolase activity", "Erbb 3 class receptor binding", "Estradiol 17 beta dehydrogenase activity", "Estrogen receptor binding", "Ether hydrolase activity", "Eukaryotic initiation factor 4e binding", "Exodeoxyribonuclease activity", "Exogenous protein binding", "Exonuclease activity", "Exonuclease activity active with either ribo or deoxyribonucleic acids and producing 5 phosphomonoesters", "Exopeptidase activity", "Exoribonuclease activity", "Exoribonuclease activity producing 5 phosphomonoesters", "Extracellular matrix binding", "Fad binding", "Fatty acid binding", "Fatty acid derivative binding", "Fatty acid ligase activity", "Fatty acid synthase activity", "Fatty acid transmembrane transporter activity", "Ferric iron binding", "Ferrous iron binding", "Fibroblast growth factor binding", "Fibronectin binding", "Fk506 binding", "Flap endonuclease activity", "Flavin adenine dinucleotide binding", "Flippase activity", "Floppase activity", "Fmn binding", "Folic acid binding", "Folic acid transmembrane transporter activity", "Four way junction dna binding", "Four way junction helicase activity", "Frizzled binding", "Fructose 2 6 bisphosphate 2 phosphatase activity", "Fructose 6 phosphate binding", "Fructose binding", "G protein activity", "G protein alpha subunit binding", "G protein beta gamma subunit complex binding", "G protein beta subunit binding", "G protein coupled glutamate receptor binding", "G protein coupled opioid receptor activity", "G protein coupled receptor activity", "G protein coupled receptor binding", "G protein coupled serotonin receptor binding", "G quadruplex dna binding", "G quadruplex rna binding", "G rich strand telomeric dna binding", "Gaba receptor binding", "Galactosidase activity", "Galactoside binding", "Galactosyltransferase activity", "Gamma aminobutyric acid transmembrane transporter activity", "Gamma catenin binding", "Gamma tubulin binding", "Ganglioside binding", "Gated channel activity", "Gdp binding", "Gdp dissociation inhibitor activity", "General transcription initiation factor activity", "General transcription initiation factor binding", "Glucocorticoid receptor binding", "Glucose binding", "Glucosidase activity", "Glucosyltransferase activity", "Glucuronosyltransferase activity", "Glutamate receptor binding", "Glutathione disulfide oxidoreductase activity", "Glutathione oxidoreductase activity", "Glutathione peroxidase activity", "Glutathione transferase activity", "Glutathione transmembrane transporter activity", "Glyceraldehyde 3 phosphate dehydrogenase nadplus non phosphorylating activity", "Glycerophospholipid flippase activity", "Glycine binding", "Glycolipid binding", "Glycolipid mannosyltransferase activity", "Glycosaminoglycan binding", "Glycosphingolipid binding", "Glycosyltransferase activity", "Gpi anchor binding", "Growth factor activity", "Growth factor binding", "Growth factor receptor binding", "Gtp dependent protein binding", "Gtpase activating protein binding", "Gtpase activator activity", "Gtpase activity", "Gtpase binding", "Gtpase inhibitor activity", "Guanyl nucleotide binding", "Guanyl nucleotide exchange factor activity", "Guanylate kinase activity", "H4 histone acetyltransferase activity", "Heat shock protein binding", "Helicase activity", "Heme transmembrane transporter activity", "Heparan sulfate proteoglycan binding", "Heparan sulfate sulfotransferase activity", "Heparin binding", "Hexokinase activity", "Hexosaminidase activity", "Hexosyltransferase activity", "High density lipoprotein particle binding", "Histone acetyltransferase binding", "Histone arginine n methyltransferase activity", "Histone binding", "Histone deacetylase activity h3 k14 specific", "Histone deacetylase binding", "Histone deacetylase regulator activity", "Histone h3 di monomethyl lysine 9 demethylase activity", "Histone h3 methyl lysine 36 demethylase activity", "Histone h3 methyl lysine 4 demethylase activity", "Histone h3 methyl lysine 9 demethylase activity", "Histone h3 tri di monomethyl lysine 4 demethylase activity", "Histone kinase activity", "Histone lysine n methyltransferase activity", "Histone methyltransferase activity", "Histone methyltransferase activity h3 k36 specific", "Histone methyltransferase activity h3 k4 specific", "Histone methyltransferase activity h3 k9 specific", "Histone methyltransferase activity h4 k20 specific", "Histone methyltransferase binding", "Histone serine kinase activity", "Histone threonine kinase activity", "Hormone activity", "Hormone binding", "Hormone receptor binding", "Hsp70 protein binding", "Hsp90 protein binding", "Hyaluronic acid binding", "Hyalurononglucosaminidase activity", "Hydro lyase activity", "Hydrolase activity acting on acid anhydrides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in cyclic amidines", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amides", "Hydrolase activity acting on carbon nitrogen but not peptide bonds in linear amidines", "Hydrolase activity acting on ester bonds", "Hydrolase activity acting on ether bonds", "Hydrolase activity acting on glycosyl bonds", "Hydrolase activity hydrolyzing n glycosyl compounds", "Hydrolase activity hydrolyzing o glycosyl compounds", "Hydroxymethyl formyl and related transferase activity", "I smad binding", "Identical protein binding", "Ige binding", "Igg binding", "Immune receptor activity", "Immunoglobulin binding", "Immunoglobulin receptor binding", "Importin alpha family protein binding", "Inorganic anion transmembrane transporter activity", "Inorganic diphosphatase activity", "Inorganic molecular entity transmembrane transporter activity", "Inorganic phosphate transmembrane transporter activity", "Inositol 1 4 5 trisphosphate 5 phosphatase activity", "Inositol phosphate phosphatase activity", "Inositol polyphosphate 5 phosphatase activity", "Inositol tetrakisphosphate phosphatase activity", "Inositol trisphosphate kinase activity", "Inositol trisphosphate phosphatase activity", "Insulin binding", "Insulin like growth factor binding", "Insulin like growth factor i binding", "Insulin like growth factor ii binding", "Insulin like growth factor receptor binding", "Insulin receptor binding", "Insulin receptor substrate binding", "Integrin binding", "Interferon receptor activity", "Interleukin 1 receptor binding", "Interleukin 2 receptor binding", "Interleukin 6 receptor binding", "Intermediate filament binding", "Intracellular calcium activated chloride channel activity", "Intraciliary transport particle b binding", "Intramembrane lipid transporter activity", "Intramolecular oxidoreductase activity", "Intramolecular oxidoreductase activity interconverting aldoses and ketoses", "Intramolecular oxidoreductase activity transposing c c bonds", "Intramolecular transferase activity", "Intramolecular transferase activity phosphotransferases", "Intronic transcription regulatory region sequence specific dna binding", "Ion gated channel activity", "Ion transmembrane transporter activity", "Ionotropic glutamate receptor binding", "Iron ion binding", "Isocitrate dehydrogenase activity", "Isomerase activity", "Isopeptidase activity", "Isoprenoid binding", "Jun kinase binding", "Jun kinase kinase kinase activity", "K48 linked polyubiquitin modification dependent protein binding", "K63 linked polyubiquitin modification dependent protein binding", "Keratin filament binding", "Kinase activator activity", "Kinase activity", "Kinase binding", "Kinase inhibitor activity", "Kinase regulator activity", "Kinesin binding", "Kinetochore binding", "L alanine transmembrane transporter activity", "L amino acid transmembrane transporter activity", "L arginine transmembrane transporter activity", "L ascorbic acid binding", "L aspartate transmembrane transporter activity", "L glutamine transmembrane transporter activity", "L histidine transmembrane transporter activity", "L lactate dehydrogenase activity", "L leucine transmembrane transporter activity", "L lysine transmembrane transporter activity", "L ornithine transmembrane transporter activity", "L serine transmembrane transporter activity", "Lactate dehydrogenase activity", "Lactate transmembrane transporter activity", "Lamin binding", "Laminin 1 binding", "Laminin binding", "Large ribosomal subunit rrna binding", "Leucine binding", "Leucine zipper domain binding", "Leukotriene c4 synthase activity", "Ligand gated ion channel activity", "Ligase activity", "Ligase activity forming carbon carbon bonds", "Ligase activity forming carbon nitrogen bonds", "Ligase activity forming carbon oxygen bonds", "Ligase activity forming carbon sulfur bonds", "Ligase activity forming phosphoric ester bonds", "Lim domain binding", "Lipase activator activity", "Lipase activity", "Lipase binding", "Lipase inhibitor activity", "Lipid binding", "Lipid kinase activity", "Lipid phosphatase activity", "Lipid transfer activity", "Lipid transporter activity", "Lipopolysaccharide binding", "Lipopolysaccharide immune receptor activity", "Lipoprotein particle receptor activity", "Lipoprotein particle receptor binding", "Long chain acyl coa dehydrogenase activity", "Long chain fatty acid binding", "Long chain fatty acid coa ligase activity", "Long chain fatty acid transporter activity", "Long chain fatty acyl coa binding", "Low density lipoprotein particle binding", "Low density lipoprotein particle receptor activity", "Low density lipoprotein particle receptor binding", "Lrr domain binding", "Lyase activity", "Lys48 specific deubiquitinase activity", "Lys63 specific deubiquitinase activity", "Lysine acetylated histone binding", "Lysine n methyltransferase activity", "Lysophosphatidic acid binding", "Lysophosphatidic acid phosphatase activity", "Lysophospholipase activity", "Lysophospholipid acyltransferase activity", "M7g 5 pppn diphosphatase activity", "Macrolide binding", "Macromolecule transmembrane transporter activity", "Magnesium ion binding", "Magnesium ion transmembrane transporter activity", "Malate dehydrogenase activity", "Manganese ion binding", "Manganese ion transmembrane transporter activity", "Mannose binding", "Mannosidase activity", "Mannosyltransferase activity", "Map kinase activity", "Map kinase kinase activity", "Map kinase kinase kinase activity", "Map kinase phosphatase activity", "Map kinase scaffold activity", "Mdm2 mdm4 family protein binding", "Medium chain fatty acid coa ligase activity", "Membrane insertase activity", "Metal cluster binding", "Metal dependent deubiquitinase activity", "Metal ion proton antiporter activity", "Metal ion transmembrane transporter activity", "Metalloaminopeptidase activity", "Metallocarboxypeptidase activity", "Metallochaperone activity", "Metallodipeptidase activity", "Metalloendopeptidase activity", "Metalloexopeptidase activity", "Metallopeptidase activity", "Methyl cpg binding", "Methylated histone binding", "Mhc class i protein binding", "Mhc class ib protein binding", "Mhc class ii protein complex binding", "Mhc protein binding", "Mhc protein complex binding", "Microfilament motor activity", "Microtubule binding", "Microtubule minus end binding", "Microtubule motor activity", "Microtubule plus end binding", "Minor groove of adenine thymine rich dna binding", "Minus end directed microtubule motor activity", "Mirna binding", "Misfolded protein binding", "Mismatch repair complex binding", "Mismatched dna binding", "Mitochondrial ribosome binding", "Mitochondrion targeting sequence binding", "Mitogen activated protein kinase binding", "Mitogen activated protein kinase kinase kinase binding", "Mitogen activated protein kinase p38 binding", "Modification dependent protein binding", "Modified amino acid binding", "Modified amino acid transmembrane transporter activity", "Molecular adaptor activity", "Molecular carrier activity", "Molecular function activator activity", "Molecular function inhibitor activity", "Molecular function regulator", "Molecular transducer activity", "Molybdopterin cofactor binding", "Monocarboxylic acid binding", "Monocarboxylic acid transmembrane transporter activity", "Monooxygenase activity", "Monosaccharide binding", "Mrf binding", "Mrna 3 utr au rich region binding", "Mrna 3 utr binding", "Mrna 5 utr binding", "Mrna binding", "Mrna methyltransferase activity", "Muscle alpha actinin binding", "Mutlalpha complex binding", "Myosin binding", "Myosin ii binding", "Myosin v binding", "Myristoyltransferase activity", "N acetyllactosaminide beta 1 3 n acetylglucosaminyltransferase activity", "N acetyltransferase activity", "N acylsphingosine amidohydrolase activity", "N acyltransferase activity", "N methyltransferase activity", "N6 methyladenosine containing rna binding", "Nad binding", "Nad dependent protein deacetylase activity", "Nad p h oxidase h2o2 forming activity", "Nad p plus protein arginine adp ribosyltransferase activity", "Nad retinol dehydrogenase activity", "Nadh dehydrogenase activity", "Nadh pyrophosphatase activity", "Nadp binding", "Nadp retinol dehydrogenase activity", "Nadph binding", "Nadplus adp ribosyltransferase activity", "Nadplus binding", "Nadplus kinase activity", "Nedd8 specific protease activity", "Nedd8 transferase activity", "Nerve growth factor binding", "Neurexin family protein binding", "Neuroligin family protein binding", "Neurotransmitter binding", "Neurotransmitter receptor activity", "Neurotransmitter receptor regulator activity", "Neurotrophin binding", "Neurotrophin receptor activity", "Neurotrophin receptor binding", "Neurotrophin trk receptor binding", "Neutral amino acid transmembrane transporter activity", "Nf kappab binding", "Nfat protein binding", "Nitric oxide synthase binding", "Nitric oxide synthase regulator activity", "Nitrite reductase activity", "Non membrane spanning protein tyrosine kinase activity", "Non membrane spanning protein tyrosine phosphatase activity", "Notch binding", "Nuclear export signal receptor activity", "Nuclear import signal receptor activity", "Nuclear localization sequence binding", "Nuclear receptor activity", "Nuclear receptor binding", "Nuclear receptor coactivator activity", "Nuclease activity", "Nucleobase containing compound kinase activity", "Nucleobase containing compound transmembrane transporter activity", "Nucleobase transmembrane transporter activity", "Nucleocytoplasmic carrier activity", "Nucleoside binding", "Nucleoside diphosphatase activity", "Nucleoside diphosphate kinase activity", "Nucleoside kinase activity", "Nucleoside monophosphate kinase activity", "Nucleoside triphosphatase regulator activity", "Nucleoside triphosphate diphosphatase activity", "Nucleosomal dna binding", "Nucleosome binding", "Nucleotidase activity", "Nucleotide diphosphatase activity", "Nucleotide phosphatase activity acting on free nucleotides", "Nucleotide sugar transmembrane transporter activity", "Nucleotide transmembrane transporter activity", "Nucleotidyltransferase activity", "O acetyltransferase activity", "O acyltransferase activity", "O methyltransferase activity", "O palmitoyltransferase activity", "Oleate transmembrane transporter activity", "Oligopeptide binding", "Oligopeptide transmembrane transporter activity", "Oligosaccharide binding", "Oligosaccharyl transferase activity", "Omega peptidase activity", "Opsonin binding", "Organic acid binding", "Organic acid sodium symporter activity", "Organic acid transmembrane transporter activity", "Organic anion transmembrane transporter activity", "Organic cation transmembrane transporter activity", "Organic hydroxy compound transmembrane transporter activity", "Organophosphate ester transmembrane transporter activity", "Oxidative phosphorylation uncoupler activity", "Oxidative rna demethylase activity", "Oxidized dna binding", "Oxidoreductase activity", "Oxidoreductase activity acting on a heme group of donors", "Oxidoreductase activity acting on a sulfur group of donors", "Oxidoreductase activity acting on a sulfur group of donors disulfide as acceptor", "Oxidoreductase activity acting on a sulfur group of donors nad p as acceptor", "Oxidoreductase activity acting on a sulfur group of donors oxygen as acceptor", "Oxidoreductase activity acting on ch oh group of donors", "Oxidoreductase activity acting on ch or ch2 groups", "Oxidoreductase activity acting on diphenols and related substances as donors", "Oxidoreductase activity acting on nad p h", "Oxidoreductase activity acting on nad p h heme protein as acceptor", "Oxidoreductase activity acting on nad p h oxygen as acceptor", "Oxidoreductase activity acting on nad p h quinone or similar compound as acceptor", "Oxidoreductase activity acting on other nitrogenous compounds as donors", "Oxidoreductase activity acting on other nitrogenous compounds as donors cytochrome as acceptor", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen nad p h as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced ascorbate as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced pteridine as one donor and incorporation of one atom of oxygen", "Oxidoreductase activity acting on paired donors with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water", "Oxidoreductase activity acting on peroxide as acceptor", "Oxidoreductase activity acting on single donors with incorporation of molecular oxygen", "Oxidoreductase activity acting on the aldehyde or oxo group of donors", "Oxidoreductase activity acting on the aldehyde or oxo group of donors disulfide as acceptor", "Oxidoreductase activity acting on the aldehyde or oxo group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors", "Oxidoreductase activity acting on the ch ch group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch ch group of donors oxygen as acceptor", "Oxidoreductase activity acting on the ch nh group of donors", "Oxidoreductase activity acting on the ch nh group of donors nad or nadp as acceptor", "Oxidoreductase activity acting on the ch nh2 group of donors", "Oxidoreduction driven active transmembrane transporter activity", "Oxygen binding", "Oxygen sensor activity", "Oxysterol binding", "P type calcium transporter activity", "P type potassium transmembrane transporter activity", "P type transmembrane transporter activity", "P53 binding", "Palmitoyl coa hydrolase activity", "Palmitoyl protein hydrolase activity", "Palmitoyltransferase activity", "Passive transmembrane transporter activity", "Patched binding", "Pattern recognition receptor activity", "Pdz domain binding", "Pentosyltransferase activity", "Peptidase activator activity", "Peptidase activator activity involved in apoptotic process", "Peptidase activity", "Peptidase regulator activity", "Peptide alpha n acetyltransferase activity", "Peptide antigen binding", "Peptide binding", "Peptide hormone binding", "Peptide hormone receptor binding", "Peptide lysine n acetyltransferase activity", "Peptide n acetyltransferase activity", "Peptide receptor activity", "Peptide transmembrane transporter activity", "Peptidoglycan binding", "Peptidyl proline 4 dioxygenase activity", "Peptidyl proline dioxygenase activity", "Peroxiredoxin activity", "Peroxisome proliferator activated receptor binding", "Peroxisome targeting sequence binding", "Phosphatase activator activity", "Phosphatase activity", "Phosphatase binding", "Phosphatase inhibitor activity", "Phosphatase regulator activity", "Phosphate ion binding", "Phosphatidic acid binding", "Phosphatidyl phospholipase b activity", "Phosphatidylcholine binding", "Phosphatidylcholine floppase activity", "Phosphatidylcholine transfer activity", "Phosphatidylcholine transporter activity", "Phosphatidylethanolamine binding", "Phosphatidylethanolamine flippase activity", "Phosphatidylglycerol binding", "Phosphatidylinositol 3 4 5 trisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate 5 phosphatase activity", "Phosphatidylinositol 3 4 5 trisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate 3 phosphatase activity", "Phosphatidylinositol 3 5 bisphosphate 5 phosphatase activity", "Phosphatidylinositol 3 5 bisphosphate binding", "Phosphatidylinositol 3 5 bisphosphate phosphatase activity", "Phosphatidylinositol 3 kinase activity", "Phosphatidylinositol 3 kinase binding", "Phosphatidylinositol 3 kinase regulatory subunit binding", "Phosphatidylinositol 3 phosphate binding", "Phosphatidylinositol 4 5 bisphosphate 3 kinase activity", "Phosphatidylinositol 4 5 bisphosphate 5 phosphatase activity", "Phosphatidylinositol 4 5 bisphosphate binding", "Phosphatidylinositol 4 5 bisphosphate phosphatase activity", "Phosphatidylinositol 4 phosphate binding", "Phosphatidylinositol 5 phosphate binding", "Phosphatidylinositol binding", "Phosphatidylinositol bisphosphate binding", "Phosphatidylinositol bisphosphate kinase activity", "Phosphatidylinositol bisphosphate phosphatase activity", "Phosphatidylinositol kinase activity", "Phosphatidylinositol monophosphate phosphatase activity", "Phosphatidylinositol phosphate 4 phosphatase activity", "Phosphatidylinositol phosphate 5 phosphatase activity", "Phosphatidylinositol phosphate binding", "Phosphatidylinositol phosphate kinase activity", "Phosphatidylinositol phosphate phosphatase activity", "Phosphatidylinositol transfer activity", "Phosphatidylinositol trisphosphate phosphatase activity", "Phosphatidylserine 1 acylhydrolase activity", "Phosphatidylserine binding", "Phosphatidylserine flippase activity", "Phosphatidylserine floppase activity", "Phosphodiesterase i activity", "Phosphofructokinase activity", "Phospholipase a1 activity", "Phospholipase a2 activity", "Phospholipase a2 inhibitor activity", "Phospholipase activity", "Phospholipase binding", "Phospholipase c activity", "Phospholipase d activity", "Phospholipase inhibitor activity", "Phospholipid binding", "Phospholipid scramblase activity", "Phospholipid transfer activity", "Phospholipid transporter activity", "Phosphoprotein binding", "Phosphoprotein phosphatase activity", "Phosphoric diester hydrolase activity", "Phosphoric ester hydrolase activity", "Phosphorus oxygen lyase activity", "Phosphoserine residue binding", "Phosphotransferase activity for other substituted phosphate groups", "Phosphotransferase activity nitrogenous group as acceptor", "Phosphotransferase activity phosphate group as acceptor", "Phosphotyrosine residue binding", "Plus end directed microtubule motor activity", "Poly a binding", "Poly a specific ribonuclease activity", "Poly g binding", "Poly purine tract binding", "Poly pyrimidine tract binding", "Polynucleotide adenylyltransferase activity", "Polypeptide n acetylgalactosaminyltransferase activity", "Polysaccharide binding", "Polysome binding", "Polyubiquitin modification dependent protein binding", "Porin activity", "Potassium channel inhibitor activity", "Potassium channel regulator activity", "Potassium chloride symporter activity", "Potassium ion antiporter activity", "Potassium ion binding", "Potassium ion transmembrane transporter activity", "Potassium proton antiporter activity", "Pre mirna binding", "Pre mrna 3 splice site binding", "Pre mrna 5 splice site binding", "Pre mrna binding", "Pre mrna intronic binding", "Prenyltransferase activity", "Primary active transmembrane transporter activity", "Primary mirna binding", "Procollagen proline 4 dioxygenase activity", "Procollagen proline dioxygenase activity", "Profilin binding", "Proline rich region binding", "Promoter specific chromatin binding", "Protease binding", "Proteasome activating activity", "Proteasome binding", "Protein adp ribosylase activity", "Protein antigen binding", "Protein arginine n methyltransferase activity", "Protein arginine omega n asymmetric methyltransferase activity", "Protein arginine omega n monomethyltransferase activity", "Protein binding involved in heterotypic cell cell adhesion", "Protein c terminus binding", "Protein carboxyl o methyltransferase activity", "Protein carrier chaperone", "Protein containing complex binding", "Protein deacetylase activity", "Protein demethylase activity", "Protein dimerization activity", "Protein disaggregase activity", "Protein disulfide isomerase activity", "Protein disulfide reductase nad p activity", "Protein domain specific binding", "Protein folding chaperone", "Protein geranylgeranyltransferase activity", "Protein glutamic acid ligase activity", "Protein heterodimerization activity", "Protein homodimerization activity", "Protein hormone receptor activity", "Protein kinase a binding", "Protein kinase a catalytic subunit binding", "Protein kinase a regulatory subunit binding", "Protein kinase activity", "Protein kinase b binding", "Protein kinase c activity", "Protein kinase c binding", "Protein lipid complex binding", "Protein macromolecule adaptor activity", "Protein membrane adaptor activity", "Protein methyltransferase activity", "Protein n terminus binding", "Protein phosphatase 1 binding", "Protein phosphatase 2a binding", "Protein phosphatase activator activity", "Protein phosphatase binding", "Protein phosphatase regulator activity", "Protein phosphorylated amino acid binding", "Protein prenyltransferase activity", "Protein self association", "Protein serine kinase activity", "Protein serine threonine kinase activator activity", "Protein serine threonine kinase activity", "Protein serine threonine kinase inhibitor activity", "Protein serine threonine phosphatase activity", "Protein serine threonine phosphatase inhibitor activity", "Protein serine threonine tyrosine kinase activity", "Protein tag", "Protein transmembrane transporter activity", "Protein transporter activity", "Protein tyrosine kinase activator activity", "Protein tyrosine kinase activity", "Protein tyrosine kinase binding", "Protein tyrosine kinase inhibitor activity", "Protein tyrosine phosphatase activity", "Protein tyrosine serine threonine phosphatase activity", "Proteoglycan binding", "Proton channel activity", "Proton transmembrane transporter activity", "Proton transporting atp synthase activity rotational mechanism", "Pseudouridine synthase activity", "Purine nucleotide transmembrane transporter activity", "Pyrimidine nucleotide binding", "Pyrimidine nucleotide sugar transmembrane transporter activity", "Pyrophosphate hydrolysis driven proton transmembrane transporter activity", "Pyruvate dehydrogenase acetyl transferring kinase activity", "Pyruvate dehydrogenase activity", "Quaternary ammonium group binding", "Quaternary ammonium group transmembrane transporter activity", "Quinone binding", "R smad binding", "Racemase and epimerase activity", "Racemase and epimerase activity acting on carbohydrates and derivatives", "Rage receptor binding", "Rdna binding", "Receptor antagonist activity", "Receptor tyrosine kinase binding", "Regulatory rna binding", "Retinal binding", "Retinal dehydrogenase activity", "Retinoic acid binding", "Retinoic acid receptor binding", "Retinoid x receptor binding", "Retinol binding", "Retromer complex binding", "Ribonuclease activity", "Ribonuclease p activity", "Ribonuclease p rna binding", "Ribonucleoprotein complex binding", "Ribonucleotide binding", "Ribose phosphate diphosphokinase activity", "Ribosomal large subunit binding", "Ribosomal protein s6 kinase activity", "Ribosomal small subunit binding", "Ribosome binding", "Rna 2 o methyltransferase activity", "Rna 7 methylguanosine cap binding", "Rna adenylyltransferase activity", "Rna binding", "Rna binding involved in posttranscriptional gene silencing", "Rna cap binding", "Rna directed dna polymerase activity", "Rna dna hybrid ribonuclease activity", "Rna methyltransferase activity", "Rna polymerase activity", "Rna polymerase binding", "Rna polymerase core enzyme binding", "Rna polymerase i general transcription initiation factor activity", "Rna polymerase i transcription regulatory region sequence specific dna binding", "Rna polymerase ii activity", "Rna polymerase ii c terminal domain binding", "Rna polymerase ii c terminal domain phosphoserine binding", "Rna polymerase ii core promoter sequence specific dna binding", "Rna polymerase ii ctd heptapeptide repeat kinase activity", "Rna polymerase ii general transcription initiation factor activity", "Rna polymerase ii general transcription initiation factor binding", "Rna polymerase ii intronic transcription regulatory region sequence specific dna binding", "Rna polymerase ii specific dna binding transcription factor binding", "Rna polymerase iii transcription regulatory region sequence specific dna binding", "Rna stem loop binding", "Rna strand annealing activity", "Roundabout binding", "Rrna adenine methyltransferase activity", "Rrna binding", "Rrna cytosine methyltransferase activity", "S acyltransferase activity", "S adenosyl l methionine binding", "S adenosylmethionine dependent methyltransferase activity", "S methyltransferase activity", "S100 protein binding", "Scaffold protein binding", "Scavenger receptor activity", "Secondary active transmembrane transporter activity", "Selenium binding", "Semaphorin receptor activity", "Sequence specific dna binding", "Sequence specific mrna binding", "Sequence specific single stranded dna binding", "Serine hydrolase activity", "Serine transmembrane transporter activity", "Serine type carboxypeptidase activity", "Serine type endopeptidase inhibitor activity", "Serine type exopeptidase activity", "Sh2 domain binding", "Sh3 domain binding", "Signal recognition particle binding", "Signal sequence binding", "Signaling adaptor activity", "Signaling receptor binding", "Signaling receptor complex adaptor activity", "Signaling receptor inhibitor activity", "Signaling receptor regulator activity", "Single stranded dna 3 5 exodeoxyribonuclease activity", "Single stranded dna binding", "Single stranded dna endodeoxyribonuclease activity", "Single stranded dna exodeoxyribonuclease activity", "Single stranded dna helicase activity", "Single stranded rna binding", "Single stranded telomeric dna binding", "Sirna binding", "Smad binding", "Small molecule sensor activity", "Small protein activating enzyme binding", "Small ribosomal subunit rrna binding", "Snap receptor activity", "Snare binding", "Snorna binding", "Snrna binding", "Snrnp binding", "Sodium channel inhibitor activity", "Sodium channel regulator activity", "Sodium chloride symporter activity", "Sodium ion binding", "Sodium ion transmembrane transporter activity", "Solute anion antiporter activity", "Solute cation antiporter activity", "Solute cation symporter activity", "Solute proton antiporter activity", "Solute proton symporter activity", "Solute sodium symporter activity", "Spectrin binding", "Sphingolipid binding", "Sphingolipid transfer activity", "Sphingolipid transporter activity", "Sphingomyelin phosphodiesterase activity", "Sphingosine n acyltransferase activity", "Steroid binding", "Steroid dehydrogenase activity", "Steroid dehydrogenase activity acting on the ch oh group of donors nad or nadp as acceptor", "Steroid hormone binding", "Steroid hormone receptor activity", "Sterol binding", "Sterol transfer activity", "Sterol transporter activity", "Structural constituent of cytoskeleton", "Structural constituent of eye lens", "Structural constituent of muscle", "Structural constituent of nuclear pore", "Structural constituent of postsynapse", "Structural constituent of presynaptic active zone", "Structural constituent of ribosome", "Structural constituent of synapse", "Structural molecule activity", "Structural molecule activity conferring elasticity", "Succinate transmembrane transporter activity", "Sugar transmembrane transporter activity", "Sulfate binding", "Sulfate transmembrane transporter activity", "Sulfatide binding", "Sulfotransferase activity", "Sulfur compound binding", "Sulfur compound transmembrane transporter activity", "Sulfuric ester hydrolase activity", "Sulfurtransferase activity", "Sumo binding", "Sumo ligase activity", "Sumo specific protease activity", "Sumo transferase activity", "Supercoiled dna binding", "Superoxide dismutase activity", "Symporter activity", "Syntaxin 1 binding", "Syntaxin binding", "T cell receptor binding", "Tap binding", "Tat protein binding", "Tau protein binding", "Tau protein kinase activity", "Tbp class protein binding", "Telomerase activity", "Telomerase inhibitor activity", "Telomerase rna binding", "Telomeric dna binding", "Testosterone dehydrogenase nad p activity", "Testosterone dehydrogenase nadplus activity", "Tetrapyrrole binding", "Tfiib class transcription factor binding", "Tfiid class transcription factor complex binding", "Thiamine pyrophosphate binding", "Thioesterase binding", "Thiol oxidase activity", "Thiolester hydrolase activity", "Thioredoxin disulfide reductase activity", "Threonine type endopeptidase activity", "Threonine type peptidase activity", "Thyroid hormone receptor binding", "Thyroid hormone transmembrane transporter activity", "Toxic substance binding", "Tpr domain binding", "Transcription coactivator activity", "Transcription coactivator binding", "Transcription coregulator activity", "Transcription coregulator binding", "Transcription corepressor activity", "Transcription corepressor binding", "Transcription elongation regulator activity", "Transcription factor binding", "Transcription regulator activity", "Transcription regulator inhibitor activity", "Transferase activity transferring alkyl or aryl other than methyl groups", "Transferase activity transferring nitrogenous groups", "Transferase activity transferring one carbon groups", "Transferase activity transferring phosphorus containing groups", "Transferase activity transferring sulphur containing groups", "Transferrin receptor binding", "Transforming growth factor beta receptor binding", "Transition metal ion binding", "Transition metal ion transmembrane transporter activity", "Transketolase or transaldolase activity", "Translation activator activity", "Translation elongation factor activity", "Translation factor activity rna binding", "Translation initiation factor activity", "Translation initiation factor binding", "Translation regulator activity", "Translation regulator activity nucleic acid binding", "Translation repressor activity", "Translation repressor activity mrna regulatory element binding", "Translation termination factor activity", "Transmembrane receptor protein kinase activity", "Transmembrane receptor protein phosphatase activity", "Transmembrane receptor protein tyrosine kinase activity", "Transmembrane transporter binding", "Transporter activity", "Tripeptide transmembrane transporter activity", "Trna binding", "Trna cytosine methyltransferase activity", "Trna guanine methyltransferase activity", "Trna methyltransferase activity", "Trna specific adenosine deaminase activity", "Trna specific ribonuclease activity", "Tropomyosin binding", "Tubulin binding", "Tumor necrosis factor activated receptor activity", "Tumor necrosis factor receptor binding", "Tumor necrosis factor receptor superfamily binding", "Type i transforming growth factor beta receptor binding", "U1 snrna binding", "U2 snrna binding", "U3 snorna binding", "U4 snrna binding", "U6 snrna binding", "Ubiquinol cytochrome c reductase activity", "Ubiquinone binding", "Ubiquitin binding", "Ubiquitin conjugating enzyme binding", "Ubiquitin ligase substrate adaptor activity", "Ubiquitin like modifier activating enzyme activity", "Ubiquitin like protein binding", "Ubiquitin like protein conjugating enzyme activity", "Ubiquitin like protein conjugating enzyme binding", "Ubiquitin like protein ligase activity", "Ubiquitin like protein ligase binding", "Ubiquitin like protein specific isopeptidase activity", "Ubiquitin like protein specific protease activity", "Ubiquitin like protein transferase activity", "Ubiquitin protein transferase activator activity", "Ubiquitin protein transferase inhibitor activity", "Ubiquitin protein transferase regulator activity", "Ubiquitin specific protease binding", "Ubiquitin ubiquitin ligase activity", "Ubiquitination like modification dependent protein binding", "Udp galactose beta n acetylglucosamine beta 1 3 galactosyltransferase activity", "Udp glucosyltransferase activity", "Udp glycosyltransferase activity", "Udp xylosyltransferase activity", "Unfolded protein binding", "Unmethylated cpg binding", "Uridylyltransferase activity", "Vascular endothelial growth factor receptor 2 binding", "Vascular endothelial growth factor receptor binding", "Very long chain fatty acid coa ligase activity", "Vinculin binding", "Virion binding", "Vitamin b6 binding", "Vitamin binding", "Vitamin d binding", "Vitamin d receptor binding", "Vitamin transmembrane transporter activity", "Voltage gated anion channel activity", "Voltage gated calcium channel activity", "Voltage gated calcium channel activity involved in cardiac muscle cell action potential", "Voltage gated calcium channel activity involved in regulation of cytosolic calcium levels", "Voltage gated cation channel activity", "Voltage gated channel activity", "Voltage gated chloride channel activity", "Volume sensitive anion channel activity", "Water channel activity", "Water transmembrane transporter activity", "Wd40 repeat domain binding", "Wide pore channel activity", "Ww domain binding", "Xenobiotic transmembrane transporter activity", "Zinc ion binding"], "available_proteins": ["AACS", "AAMP", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABRAXAS2", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AGTRAP", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK6", "AKAP1", "AKAP12", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG5", "ALKBH5", "ALYREF", "AMOT", "AMPD2", "ANAPC1", "ANAPC2", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3M1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOBEC3C", "APOL2", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARHGEF7", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6", "ARL6IP1", "ARL8A", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ASAH1", "ASCC1", "ASCC3", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATG9A", "ATIC", "ATP11C", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPIF1", "ATXN2L", "AUP1", "B3GALT6", "B4GAT1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BCAP31", "BCCIP", "BCL2L13", "BCLAF1", "BCOR", "BCS1L", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRD1", "BRD2", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C1QBP", "C1orf123", "C1orf35", "CAB39", "CACNA2D1", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASK", "CAST", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC137", "CCDC22", "CCDC47", "CCDC6", "CCDC86", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD47", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CENPF", "CEP44", "CEP55", "CEPT1", "CERS2", "CFAP20", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD7", "CHEK2", "CHERP", "CHID1", "CHKA", "CHMP2A", "CHMP2B", "CHMP4B", "CHMP5", "CHMP6", "CHORDC1", "CHTF18", "CHTOP", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT7", "CNOT9", "CNP", "COG2", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS4", "COPS5", "COPS6", "CORO1C", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX7A2", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWC22", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBR1", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS13", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX34", "DHX35", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DIP2B", "DIS3", "DKC1", "DLAT", "DLD", "DLGAP5", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC17", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOCK7", "DOHH", "DPH5", "DPM1", "DPP3", "DPYSL2", "DR1", "DRG1", "DRG2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "DYNLL2", "DYNLT1", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMOD2", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERCC6L", "ERG28", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESYT1", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC5", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FAF1", "FAF2", "FAHD1", "FAM120A", "FAM208A", "FAM213A", "FAM49B", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD5", "FAU", "FBL", "FBXO7", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP10", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FMR1", "FN3KRP", "FNDC3A", "FNTA", "FNTB", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "FYTTD1", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCLM", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GGH", "GHDC", "GIGYF2", "GLA", "GLB1", "GLB1L2", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGB1", "GOT1", "GOT2", "GPAA1", "GPATCH4", "GPD1L", "GPD2", "GPHN", "GPI", "GPR107", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSDME", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GTF2F1", "GTF2I", "GTF3C4", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HEBP2", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HEXIM1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGA2", "HMGB1", "HMGB2", "HMGB3", "HMGCR", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPF1", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA12A", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICE1", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFIT5", "IFNGR1", "IFT27", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INCENP", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQSEC1", "IRF2BPL", "IRS4", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITM2B", "ITPA", "ITPK1", "IVD", "JMJD6", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0368", "KIAA1147", "KIF11", "KIF14", "KIF18A", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "LAMP1", "LAMTOR1", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIG3", "LIMA1", "LIN28B", "LLGL1", "LMAN1", "LMAN2", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRSAM1", "LRWD1", "LSM14A", "LSM2", "LSM4", "LSM6", "LSM7", "LSM8", "LSS", "LTA4H", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGT1", "MAK16", "MANBA", "MANF", "MAP1B", "MAP2K1", "MAP2K4", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKS", "MARCKSL1", "MARS", "MAT2A", "MAT2B", "MATR3", "MAU2", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MDC1", "MDH1", "MDH2", "MDN1", "ME2", "MECP2", "MED24", "MED4", "METTL13", "METTL16", "MFAP1", "MFF", "MFN1", "MFN2", "MFSD10", "MFSD14B", "MFSD3", "MFSD5", "MFSD8", "MGAT1", "MGEA5", "MGME1", "MGST3", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MIPEP", "MKI67", "MKRN2", "MLEC", "MMS19", "MOGS", "MORC2", "MORF4L1", "MOV10", "MPG", "MPHOSPH10", "MPHOSPH8", "MPI", "MPP2", "MPP7", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL45", "MRPL47", "MRPL51", "MRPL9", "MRPS11", "MRPS15", "MRPS17", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTPN", "MTR", "MUT", "MYBBP1A", "MYCBP", "MYCBP2", "MYEF2", "MYG1", "MYH10", "MYH9", "MYL6", "MYL6B", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA40", "NAA50", "NAE1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NCAPD2", "NCAPD3", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "ND1", "NDC1", "NDUFA10", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV2", "NEDD4L", "NEFM", "NEK9", "NELFB", "NELFCD", "NELFE", "NENF", "NF1", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIT2", "NKRF", "NKTR", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NOVA2", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "OXCT1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PAPSS2", "PARK7", "PARN", "PARP1", "PAWR", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDXDC1", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHF6", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PIBF1", "PICALM", "PIGK", "PIK3C2A", "PIK3R4", "PIN4", "PIR", "PITPNB", "PITRM1", "PKM", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "POLA1", "POLD1", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "PON2", "POP1", "POP7", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL4", "PPM1F", "PPM1G", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA1", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38A", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PRSS3", "PRTFDC1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSPC1", "PTBP1", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS7", "PWP1", "PWP2", "PWWP2A", "PYCR1", "PYCR2", "PYGB", "PYGL", "PYM1", "QARS", "QKI", "QPRT", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB23", "RAB2A", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "REPS1", "RER1", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIDA", "RIPK1", "RMDN1", "RNASEH2A", "RNASET2", "RNF14", "RNF2", "RNF20", "RNF219", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK1", "RPA1", "RPA2", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP1B", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RTCB", "RTN4", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAP18", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SBNO1", "SCAF1", "SCAF11", "SCAF4", "SCAMP3", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SCYL2", "SDE2", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC13", "SEC14L2", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SELENBP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHMT2", "SHTN1", "SIGMAR1", "SIL1", "SIN3A", "SIRT1", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC2A1", "SLC30A7", "SLC35A4", "SLC35B2", "SLC35F2", "SLC38A1", "SLC3A2", "SLC7A1", "SLC7A5", "SLC9A3R1", "SLC9A6", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMYD3", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SORT1", "SPAG5", "SPAG9", "SPART", "SPC24", "SPCS2", "SPCS3", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRFBP1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STIP1", "STMN1", "STOML2", "STRAP", "STRBP", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SV2A", "SWAP70", "SYNCRIP", "SYNE2", "TAB1", "TAF15", "TAF2", "TAF5", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TAOK1", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D15", "TBC1D4", "TBC1D8B", "TBC1D9B", "TBCA", "TBCD", "TBCE", "TBK1", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCF25", "TCOF1", "TCP1", "TECR", "TELO2", "TERF2IP", "TES", "TFAM", "TFB1M", "TFG", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "TIA1", "TIAL1", "TIGAR", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TJP1", "TK1", "TKT", "TLN1", "TMCO1", "TMED10", "TMED9", "TMEM109", "TMEM115", "TMEM192", "TMEM201", "TMEM43", "TMOD3", "TMPO", "TMPO", "TMTC3", "TMX1", "TMX2", "TNPO1", "TNPO3", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1AIP2", "TOX4", "TP53", "TP53BP1", "TP53BP2", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPRKB", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMT11", "TRMT112", "TRMT1L", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSNAX", "TSPO", "TSPYL1", "TSR1", "TSR3", "TST", "TSTA3", "TTC1", "TTC21B", "TTC26", "TTC4", "TTLL12", "TTLL4", "TTYH3", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNRD1", "TXNRD2", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBFD1", "UBL5", "UBLCP1", "UBQLN4", "UBR1", "UBR4", "UBR5", "UBTF", "UCHL5", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRC1", "UQCRC2", "UQCRFS1", "URB1", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP33", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VMP1", "VPS16", "VPS25", "VPS33B", "VPS35", "VPS4A", "VPS4B", "VPS50", "VRK1", "VRK3", "VTA1", "VWA8", "WARS", "WARS2", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR12", "WDR3", "WDR33", "WDR36", "WDR43", "WDR46", "WDR5", "WDR6", "WDR75", "WDR77", "WDR82", "WFS1", "WIZ", "WNK1", "WTAP", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS2", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBTB10", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCRB1", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM4", "ZMYND8", "ZNF207", "ZNF318", "ZNF326", "ZNF512B", "ZNF638", "ZPR1", "ZRANB2", "ZW10", "ZYX"], "leading_proteins": ["AAMP", "AARS2", "ABCB1", "ABHD10", "ACAD11", "ACAT2", "ACO1", "ACOX1", "ACOX3", "ACP2", "ACP6", "ACTN1", "ACTN4", "AGL", "AGPAT1", "AGPS", "AGTRAP", "AIFM1", "AKAP8", "AKAP8L", "ALDH3A2", "AMOT", "ANAPC2", "ANK3", "ANKLE2", "ANP32A", "ANP32B", "ANXA1", "ANXA11", "APLP2", "APOBEC3C", "APOL2", "APPL1", "ARMT1", "ASCC3", "ASPH", "ATAD2", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5L", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1C1", "ATP6V1E1", "AUP1", "B4GAT1", "BABAM2", "BAG6", "BAIAP2", "BCL2L13", "BICD2", "BSG", "C1QBP", "CACYBP", "CAP1", "CARM1", "CASK", "CBX1", "CBX3", "CCT5", "CDC37", "CDC42", "CDK1", "CDK12", "CDK13", "CDK4", "CDKAL1", "CERS2", "CHD1", "CHKA", "CIRBP", "CLCN3", "CLN5", "CLPP", "CLUH", "CNNM3", "COLEC12", "COMT", "COPS4", "COPS5", "COPS6", "CPD", "CPNE1", "CPT2", "CRKL", "CTBP1", "CTNNB1", "CTSA", "CTSB", "CTSC", "CUTA", "CYB5B", "CYB5D2", "CYFIP1", "CYP51A1", "DCPS", "DCTN2", "DCUN1D1", "DDX5", "DHCR24", "DHFR", "DHX9", "DNAJA1", "DNAJA2", "DNAJB11", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DOHH", "DPM1", "DSG2", "DYNC1LI2", "ECE1", "ECI1", "EIF3L", "EIF4B", "EIF4G1", "EIF5", "ELOC", "ELP2", "ELP3", "EPHX1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERGIC3", "ERLIN1", "ETFDH", "EXO1", "EXOSC6", "EXOSC8", "F11R", "FAM49B", "FBXO7", "FCGRT", "FDFT1", "FECH", "FERMT2", "FGFR1OP", "FKBP10", "FKBP1A", "FMR1", "FNTB", "FOXRED1", "FTO", "FUBP3", "FUCA2", "FUS", "FXR1", "FXR2", "GAA", "GAK", "GALNT1", "GALNT7", "GART", "GBA", "GGH", "GLA", "GLB1", "GLB1L2", "GLDC", "GLG1", "GLMN", "GLO1", "GM2A", "GPAA1", "GPR107", "GRB2", "GSDME", "GSTM3", "GSTO1", "GUSB", "GYS1", "HADH", "HDAC1", "HDAC2", "HDGFL2", "HEXA", "HEXIM1", "HGS", "HLA-A", "HLA-B", "HLA-C", "HM13", "HMCES", "HMGA2", "HMOX1", "HMOX2", "HNRNPA2B1", "HNRNPAB", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPK", "HNRNPL", "HNRNPR", "HPF1", "HSP90AA1", "HSP90AB1", "HSPA13", "HSPA1B", "HSPA8", "HSPB1", "HTT", "ICMT", "IDE", "IDH1", "IDH2", "IFNGR1", "IGBP1", "IGF2BP2", "IGF2R", "IPO7", "IPO9", "IRS4", "ITM2B", "KDM1B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA1147", "KIF2C", "KMT2A", "KPNA1", "KPNA3", "KPNA4", "KPNA6", "KYAT3", "LANCL1", "LARP1", "LARP4", "LARP7", "LBR", "LGALS3", "LGALS3BP", "LMAN2", "LNPEP", "LPCAT1", "LRP1", "LRPAP1", "LRWD1", "LTA4H", "MAP2K1", "MAP2K4", "MARC1", "MBD3", "MCL1", "MCM2", "MCM5", "MCM6", "METTL13", "MFSD14B", "MFSD3", "MFSD8", "MGEA5", "MGME1", "MID1", "MIF", "MINDY3", "MPG", "MPP2", "MRE11", "MSH2", "MSH6", "MSMO1", "MTAP", "MTMR6", "MTOR", "MTPAP", "MYL6", "MYL6B", "NAA40", "NAE1", "NAGLU", "NAMPT", "NAP1L1", "NAP1L4", "NASP", "NCSTN", "NDC1", "NDUFB3", "NDUFB9", "NDUFS2", "NENF", "NKTR", "NLN", "NMT1", "NPC1", "NPC2", "NPEPPS", "NSD2", "NSUN2", "NT5C3B", "NT5DC1", "NTMT1", "NUCB2", "NUP107", "NUP160", "NUP85", "OLA1", "OSBPL8", "OTUB1", "OXA1L", "P3H1", "P3H4", "P4HA1", "P4HB", "PABPC1", "PABPC4", "PAIP1", "PAIP2", "PAPOLA", "PAPSS1", "PAWR", "PBK", "PCNA", "PCYOX1", "PDCD5", "PDCL3", "PDE6D", "PEBP1", "PECR", "PEX19", "PFDN4", "PFDN6", "PFN1", "PFN2", "PGRMC1", "PGRMC2", "PHC2", "PHF6", "PIBF1", "PIR", "PITRM1", "PLA2G15", "PLAA", "PLBD2", "PLD3", "PLD6", "PMPCA", "POLDIP2", "POLE", "POLE4", "POLR2D", "PON2", "PPAT", "PPP1CA", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP6R3", "PPT1", "PPT2", "PRCP", "PRKAA1", "PRKAR1A", "PRMT1", "PRMT5", "PSAP", "PSMA3", "PSMA6", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSME2", "PSME3", "PTGES2", "PTGR1", "PTPN11", "PTPRF", "PUM1", "PURA", "PUS7", "PYM1", "QKI", "QSOX2", "RABGGTA", "RALA", "RANBP3", "RBM10", "RBM14", "RBM22", "RBM4", "RBM5", "RBMX", "RECQL", "RER1", "RNASET2", "RNF14", "RNF2", "RNF20", "RPL10", "RPN2", "RPS3", "RRM2", "RTN4", "SACM1L", "SCARB1", "SCARB2", "SCCPDH", "SCPEP1", "SDHB", "SEC14L2", "SEC23B", "SET", "SETD2", "SHMT2", "SIRT2", "SLC16A1", "SLC25A10", "SLC25A15", "SLC25A20", "SLC25A26", "SLC25A32", "SLC35B2", "SLC35F2", "SLC7A5", "SMARCE1", "SMYD3", "SNX5", "SNX6", "SORT1", "SPART", "SPTLC2", "SQLE", "SQSTM1", "SRP68", "SRP72", "STAM", "STARD3NL", "STAT1", "STT3A", "STUB1", "STX8", "SUPV3L1", "SURF4", "SUZ12", "SYNCRIP", "TAB1", "TAF15", "TAOK1", "TCAF1", "TFAM", "TFRC", "THOP1", "TIA1", "TIAL1", "TIMM17A", "TIMM17B", "TIMM44", "TMEM192", "TMEM201", "TNPO1", "TOMM20", "TOMM22", "TOR1AIP2", "TP53", "TP53BP1", "TPP1", 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0.2141266987491498 1.7388858389175554 1.4384831140913243 1.3548711699904423 0.2434324139099127 0.1756432640316061 1.0 0.0023694947377154 0.0042924995678 0.0446088038944012 +Increased intracranial pressure 9 17 2.357543608387651 0.0183962944513629 4.483009708737864 18.225728155339805 0.6089364319190148 0.5193135356051898 2.352895895910637 2.1988563231789326 0.7556358037224847 0.3144749703857186 1.0 1.0 1.0 0.0127222619547071 0.0611543838186325 +Malignant neoplasm of the central nervous system 6 20 2.342412153462797 0.0191595437659515 6.453883495145631 23.82766990291262 -0.1035875416121286 0.5489059085312997 4.178110952578651 3.916843315852553 0.9853841716312314 0.3143838966418644 0.4004851411348123 1.0 0.1588529428511447 0.0328918504861857 0.0670258998725707 +Pathologic fracture 4 12 2.337772607049469 0.0193990473478535 4.257281553398058 15.072815533980584 0.983166532607372 0.3143076297274698 2.133145812327421 2.2800397788540345 1.0713003315034937 0.2893419439464214 0.2359935726254116 0.1747599807978781 0.0061250241039257 0.0140312853386763 0.0390278099301106 +Enchondroma 2 10 2.312757961973712 0.0207359502500668 3.1674757281553396 8.941747572815533 -0.1573377930464146 0.3646828517313277 2.0225933647952545 0.7641893060648111 1.3390024615924572 0.3130810820086085 0.098240976313303 1.0 0.0088504827764808 0.0050923434600555 0.0334620993119388 +Neurodegeneration 10 29 2.303305498811948 0.021261660476419 6.381067961165049 28.4126213592233 0.4868261799791588 0.5776802355314765 3.0342592105069612 2.3821007132544736 0.7766560160165384 0.3229356835194168 0.0733055917519189 0.2742474624411909 0.1290920553826253 0.0001576874873768 5.741587504110391e-05 +Lymphedema 4 12 2.296410762832064 0.021652406162969 3.6189320388349513 14.347087378640778 0.107239507031517 0.6163958292005428 2.419165150316839 1.9089508789867775 0.7794097257730709 0.2852331294761202 1.0 1.0 0.3955810682553247 0.0362911702166911 0.106558868417216 +Abnormality of the lymphatic system 26 125 2.29510223708878 0.0217272659153071 29.699029126213592 145.21601941747574 0.1994066708674118 0.5892027724934705 8.709814742221091 14.879269336886908 1.105110161252099 0.3641956683310547 0.588796378387763 0.8909801319916264 0.0614282883955963 0.0009891753705216 0.038263205530001 +Increased cerebral lipofuscin 3 5 2.282889205199893 0.0224368955109954 3.0970873786407767 5.118932038834951 1.0434065701738664 0.1270836154757583 1.1278862704044743 0.4599818751628888 1.7720117842909846 0.2267161680252343 0.0020178267542249 0.0479914252810258 0.0039135152062846 6.194004931981708e-05 0.0009118158302113 +Talipes equinovarus 20 61 2.279432805989392 0.0226413500420423 17.890776699029125 76.62135922330097 0.5495068800315274 0.5880189289841166 6.331475723212702 10.674910704116524 0.8250227780407152 0.350320151193932 0.5109892685627062 0.3443282275566168 0.693184582288109 0.2502431215746858 0.1503522412385273 +Optic disc pallor 9 39 2.270338210487344 0.0231870703638539 14.480582524271844 48.592233009708735 1.02733963234224 0.3801436604957769 5.692535706296588 6.181615230530596 1.3595924408188145 0.3692839687174071 0.0094755039527883 0.0028525731907948 0.0290362076287452 0.0088791910495065 0.0143684953141881 +Melanocytic nevus 6 11 2.24945133725567 0.0244837955440291 3.3155339805825244 11.87621359223301 0.1831092578633554 0.6574516426692707 2.2880974112586263 1.7325320246720637 0.7194568728804903 0.2908436611887262 1.0 1.0 0.3467918934582977 0.0893115916137597 0.1636366172223574 +Goiter 3 6 2.2485188454413425 0.0245431247796756 2.6844660194174756 8.25242718446602 0.6101001322888668 0.361705743263382 1.3785638567356056 1.7624367872817217 1.1902904119866486 0.3002320766724904 0.1925534392463908 1.0 0.2590666885683055 0.0062346640440273 0.0612536211646263 +Disproportionate short limb short stature 8 16 2.2440827396274083 0.0248270782935351 6.587378640776699 19.902912621359224 1.344701363676014 0.2682000023842777 2.8599402401133336 3.1206003999939886 0.9439707190715964 0.2973700803613334 0.0792517802776603 0.0437266531990119 0.0275216398495969 0.0814773755217055 0.0460574281433519 +Muscle stiffness 2 20 2.241337379527045 0.025004229428243 5.109223300970874 19.216019417475728 1.2530133657268057 0.2695837776665858 2.5817154639007844 2.4582801786037667 1.0397164239726309 0.2961148999712332 0.0546505517115555 0.0296703391700837 0.0978881295505725 0.1467586347483675 0.2772342220922595 +Abnormal thyroid morphology 5 33 2.2296936342843674 0.0257677887847116 7.762135922330097 38.72330097087379 0.1046283253708922 0.6745916164559053 4.27645657931061 4.11204019198311 0.7403654486799703 0.307003572584863 0.5428721138507782 1.0 0.2961867551178612 0.0555655068618841 0.4711720313404655 +Abnormality of glycolipid metabolism 3 7 2.2226682326715963 0.0262381795054127 3.83495145631068 7.228155339805825 0.3163887308740252 0.1681411938672545 1.311614193945771 0.5964160722258837 1.870431483654663 0.2292796295173983 1.0 1.0 1.0 0.0014684283121974 0.0009118158302113 +Abnormal conjunctiva morphology 14 26 2.2205112795993966 0.0263840808655779 6.997572815533981 26.58495145631068 0.5265054436970301 0.4429378103171669 2.669041123051977 2.4927208099742058 1.133049116684961 0.3300379664677785 0.4818610905426624 1.0 0.6021961386739574 0.007976907507528 0.0407161489813638 +Reduced visual acuity 16 98 2.2192057932930966 0.0264727271274356 25.553398058252423 114.88106796116504 0.4786956822479749 0.5063280215354549 8.433035081523723 11.838637206126975 1.2158495541746812 0.3830713742278179 0.029954305101829 0.0257136443113427 0.1122092796882407 0.0383423359764136 0.1619890429263338 +Central scotoma 3 10 2.2075046670088456 0.0272788213058099 3.657766990291262 9.152912621359222 1.2790732929494344 0.2261272578521709 2.0233738200365714 2.077016218281829 1.2675536526802949 0.279373459017325 0.0145992796040203 0.0076498462283805 0.0274603336438859 0.0037492480554313 0.008785557350241 +Pulmonary fibrosis 4 16 2.194731331390187 0.0281828758407691 3.934466019417475 19.601941747572816 0.249651568228048 0.5789497476216486 2.416182589767948 1.353455167270249 0.790614601405684 0.2834869501430559 1.0 1.0 0.0748026769138462 0.1038817567329197 0.0762091064419948 +Pleural effusion 7 9 2.192471837281475 0.0283454544646999 2.9805825242718447 10.919902912621358 0.7132265525387661 0.4494075026638777 1.784401575053615 1.8370227047476868 0.7991368875087426 0.2902305603934778 1.0 1.0 0.3467918934582977 0.0893115916137597 0.0187017730028202 +Neoplasm by histology 16 91 2.1856603372505106 0.0288404647073319 24.1626213592233 100.4004854368932 -0.0695215913268657 0.6299759235194263 11.89763217539116 10.591363937454569 0.8403649349967283 0.3117129870709569 0.0397088976844574 0.1505216093750881 0.0482558207910852 0.0680643342245408 0.1183355200830288 +Neoplasm of the nervous system 11 43 2.182614566586068 0.0290642061564527 11.822815533980584 48.23300970873787 -0.1802500971143466 0.6254658302050053 6.245010733622454 6.229360302358884 0.7922345469946627 0.3074763076117138 0.2880577431335224 0.5359669486531639 0.1869684856984573 0.0340498339031664 0.074056167765242 +Posteriorly rotated ears 24 94 2.170091088257052 0.0299999461730944 22.179611650485437 108.6504854368932 0.4817735830108808 0.6409255719604446 7.3320530406518625 12.346894376126524 0.7519045403366967 0.3519188615999026 0.4110792100915085 0.2298054416284537 0.106556093656772 0.1941646900378841 0.2091430151799636 +Multiple enchondromatosis 2 6 2.1601064331110904 0.0307644311326518 2.3907766990291264 5.83252427184466 -0.1493414935196237 0.3058932703062575 1.4381124288120406 0.3734000651234257 1.4514389248320605 0.2926213640255996 0.0601419618340726 1.0 0.0031504918831051 0.0010464818333657 0.0076703518288617 +Avascular necrosis 8 19 2.15532794699089 0.0311361803401108 5.070388349514563 21.203883495145632 0.6420454351604097 0.3947374085674277 2.2614105153836106 2.2592172512550373 1.1319127818663337 0.3183649666305153 0.3254878274356552 1.0 0.0021465314893355 0.0024061053673092 0.0015622461376846 +Abnormality of the alveolar ridges 2 6 2.151012017543585 0.0314752511494536 2.1092233009708736 6.368932038834951 1.3424122348723253 0.2105791674194365 1.182482323454481 1.3741037061958896 0.9200079991465796 0.2386077675723682 0.0167389364845026 0.0087935329278829 0.031373049189738 0.0319451393300601 0.1645088237572309 +Thickened skin 26 89 2.1505300352746186 0.0315133128295945 22.009708737864077 100.32766990291262 0.4385550996860712 0.6098739890089617 6.832596267878453 10.09935648280444 0.8592900670649001 0.3543867989618216 0.8492607095058011 1.0 0.7391608604175277 0.0023675020846993 0.0064794454607311 +Prenatal movement abnormality 16 50 2.1481586893405717 0.0317011512033806 12.398058252427184 58.41504854368932 0.2301808818459553 0.6896691980273608 4.94501770604631 6.063584343829225 0.6421785295244297 0.2980837946342114 0.0725920792723464 0.502402347983314 0.0467361955920432 0.253980816770823 0.3774236679709116 +Biliary cirrhosis 3 6 2.1448377659364755 0.031965820508484 1.9733009708737863 6.650485436893204 1.1218722294682368 0.279893930524248 1.1603338056285764 0.598683634692072 0.8535321112514973 0.2502325498718601 1.0 1.0 0.1094892401774078 0.0025975272437437 0.0019884945269669 +Rhizomelia 5 10 2.143420643578091 0.0320793369302123 4.276699029126213 11.868932038834952 1.3783619481702345 0.228956695884812 2.09278482575067 1.6655579622091714 0.936017394236602 0.2616202806826952 0.0396104283643838 0.0212633176973237 0.0720571885403784 0.0989248704147511 0.0707827064406983 +Sarcoma 8 54 2.14241396687307 0.0321601849670378 13.49271844660194 59.24757281553398 0.2024053329324482 0.5878401261352646 7.66928341789692 5.604858236953758 0.9869836607136444 0.3372231979111714 0.0124191228150678 0.1349531687426338 0.0084980050977086 0.0043991787336563 0.0110417043403743 +Abnormal pleura morphology 7 16 2.1306764087011176 0.0331158099134307 5.830097087378641 21.546116504854368 0.7290082089123371 0.4905463652617658 2.6668163977506785 3.2642978200941286 0.7757959562897808 0.3157493889189873 1.0 1.0 0.5396055987962411 0.0437821029600269 0.0397101526831211 +Abnormal pericardium morphology 7 9 2.127793173224327 0.0333542356407079 3.487864077669903 10.762135922330096 1.0304485268572945 0.2849705132346721 1.7172308655515107 1.695717994097398 1.0794817436655069 0.2735310781030822 1.0 1.0 0.0420348553288257 0.0086864012748381 0.0053527619374205 +Cerebral palsy 3 10 2.124970050282991 0.0335891120398266 3.3155339805825244 10.322815533980584 0.327647367871302 0.4350980952086785 1.85452777238683 1.3053898108248347 1.2120349360022649 0.3317594862887821 0.1813184185868616 1.0 0.2445730022705269 0.0319451393300601 0.0498364179528963 +Macrogyria 2 5 2.1184865193351774 0.0341338854045638 1.5024271844660195 5.648058252427185 0.9880312678764684 0.314713035809367 1.057793055191099 0.9137148736849272 0.850980571286911 0.2493075505833739 0.0098222160934675 0.0051137089586154 0.018640880521655 0.0152248647419399 0.088385561156941 +Hypersplenism 2 6 2.118439902505184 0.034137829529423 2.7184466019417477 7.970873786407767 0.2142260937784027 0.1548364087136437 1.1589036979530396 1.1444786041391362 1.8316571038254568 0.2005205006822401 1.0 1.0 0.0100519320580488 0.0061570039439817 0.0397387250697101 +Scotoma 4 13 2.117557479331333 0.0342125624921554 4.189320388349515 12.196601941747574 1.1271039056750725 0.2779036999445621 2.1128553643245884 2.0698220238662226 1.1901076059375446 0.2884356618441315 0.0306438092389514 0.0163255968864409 0.0563311776114605 0.0025916473916576 0.0119603409362114 +Abnormality of skull ossification 4 12 2.116196590527987 0.0343280910810956 4.366504854368932 12.970873786407768 1.1881205011944458 0.2637442069575459 1.99249670608582 1.4511884027191762 0.8848235988748787 0.2626440236811827 0.2091215881148182 1.0 0.0041517217414646 0.0086864012748381 0.0229507437408614 +Coarse hair 3 16 2.087360224458441 0.0368555846044971 4.686893203883495 18.616504854368937 0.2343700701412837 0.5417146669091575 2.329949176130645 1.927954652781107 0.8671729178541636 0.2932988727143946 0.2464885566659048 0.1828652209005429 0.0070463522145746 0.0166437437365411 0.1361773244383703 +Periventricular white matter hyperintensities 2 7 2.0851421747021988 0.0370563969567814 2.978155339805826 8.604368932038835 0.7206271937008832 0.2495118997135797 1.313488091366194 1.3113693798075805 1.4898193087366574 0.2872267653893681 0.098240976313303 0.0711332726649859 0.1349531130589082 0.0495157384890535 0.0334620993119388 +Short palpebral fissure 7 30 2.083594700538044 0.0371970494693005 6.29126213592233 27.92233009708738 0.3913672129346548 0.6272266742698988 3.03660857057613 3.451295860157005 0.6967404872312752 0.3059936066215196 0.1110104387560092 0.3361355940595682 0.1897338295109766 0.0149319876934548 0.0188615730839656 +Cystic hygroma 5 7 2.0834939180331977 0.0372062255023535 1.9975728155339805 7.694174757281553 0.4180253768272444 0.582128414388285 1.6858906009834405 1.3177890606219358 0.6893959425890075 0.2803717296643887 1.0 1.0 0.266209970857853 0.0411512789917762 0.0179733508374719 +Renal dysplasia 3 10 2.053046756362396 0.04006804304496 3.78883495145631 13.800970873786408 0.1962909475982062 0.6488877568253911 2.4537610525183715 2.7278141306163985 0.6883253326438442 0.284228267947969 0.3393635200849461 0.2560754722464486 0.4407605172427877 0.1760149897618766 0.3326328598090462 +Abnormal oral frenulum morphology 1 13 2.052529142689877 0.040118265822439 2.716019417475728 13.735436893203884 0.3454700618978792 0.6034142920110255 2.1394209541463405 1.7968166439129996 0.709663080907823 0.2878232574311347 0.0278614928576642 0.1706778675257841 0.0513963234576887 0.2332121755087385 0.2801972283088816 +Cardiovascular calcification 1 9 2.049136895574918 0.0404487305717264 2.308252427184466 8.859223300970873 0.7108888353244642 0.3297311623074345 1.5295249133480504 1.112413355910707 1.118415370096058 0.2755617850539273 0.1641763697723149 1.0 0.0255840399150975 0.1292409073430241 0.3621483333283614 +Cerebral inclusion bodies 6 14 2.0483500427290453 0.0405257128373288 3.844660194174758 13.655339805825244 0.5051551663301821 0.4226246963159299 1.8115448621120656 1.6612796655742368 1.090041660052819 0.3107400387490911 1.0 1.0 0.0398064357050217 0.0444854600227105 0.0045924061823516 +Muscle abnormality related to mitochondrial dysfunction 5 28 2.038750827500452 0.0414749021622935 11.12378640776699 35.58252427184466 0.9791864828781052 0.3365990386989574 4.6259837298613 4.333263242301439 1.4740065920951253 0.3430734831138388 0.0752709197945544 0.0414278249847813 0.1323300889211223 0.0212699465140733 0.0140935967091553 +Cupped ear 1 12 2.033655670713711 0.0419863245977212 2.3179611650485437 12.764563106796116 0.7982932305779684 0.4421342276468993 1.7676619735856678 1.9903667402216707 0.7602182664838703 0.2945303748359003 0.2670540153627264 0.1988423464133734 0.0693457394610891 0.2961580697833918 0.1732034237667374 +Neoplasm of the pituitary gland 7 15 2.032942046043256 0.0420583784467472 4.143203883495145 15.342233009708735 0.0508729963328467 0.5121310391938935 2.6959836051445527 2.391705501904948 1.0573475815766205 0.3195105429159078 0.287065986663278 1.0 0.3777229935777695 0.1140816659952819 0.0877145718471434 +Retinopathy 12 25 2.0193534841727883 0.0434504925857672 7.716019417475728 27.516990291262136 0.7648928031827923 0.4912060355555205 3.3040774573673595 3.4588008851352714 0.8590527654816497 0.3424638793573584 0.4289203261011757 0.3295231102555642 0.5440657264544094 0.0457838139336303 0.0162906747230869 +Aplasia hypoplasia involving the skeletal musculature 1 9 2.017010101979112 0.0436944591105226 2.4101941747572817 9.259708737864075 0.5828831505506118 0.4604979976196062 1.3984016400026793 1.3175543365377669 0.8139971763281372 0.2755610854392571 0.0265109458224097 0.0140700862732742 0.048990890514732 0.224257489169728 0.5423832826720252 +Joint contracture of the hand 12 39 2.0095683282495247 0.0444768961551043 9.33495145631068 47.52427184466019 0.6899528308551226 0.5319748768374064 4.138903957392258 6.987637711020041 0.8046601985034184 0.3400891059680895 0.3437747667836866 0.5842783295940941 0.241997479766437 0.6223384604622804 0.7626279500268784 +Limb girdle muscle weakness 3 23 2.0034489720419115 0.0451291195036764 6.385922330097087 25.211165048543688 0.7046294396116228 0.4863231890570912 2.9011373520939956 3.1532956410624498 0.797735822235521 0.3186211542147555 0.3662761885399084 0.2778293030066073 0.4724360815693985 0.2130027955338551 0.3996311858230128 +Neuronal loss in central nervous system 4 12 1.9975515621593496 0.0457652990753498 4.087378640776699 12.526699029126211 0.982175765643533 0.2959736314179056 1.731247914675439 1.993135251988059 1.1236470294677874 0.2967990988512021 1.0 1.0 0.0334071197556988 0.0006827439557333 0.0137665493817408 +Nasogastric tube feeding in infancy 4 9 1.9975384473865367 0.0457667222000039 3.0097087378640777 8.495145631067961 1.0003947416243104 0.2675726652756056 1.510449978803449 1.1668877069106371 1.1016283190777107 0.2724768109071007 1.0 1.0 1.0 0.154226710893935 0.1645088237572309 +Aspiration 5 11 1.9893727218950752 0.0466600782207711 2.6699029126213594 9.79126213592233 -0.0172085582186148 0.5174459915750989 2.0521754950341604 1.2464011724725987 1.0157484074741647 0.3174080591477043 1.0 1.0 1.0 0.3559534457378639 0.0097510399506001 +Abnormal caudate nucleus morphology 2 7 1.985723781127944 0.047064002915655 2.8519417475728157 10.133495145631068 0.4630014218675518 0.4635627378613905 1.7037711217888412 1.7774598482419672 0.9891574305728495 0.3131768373752813 1.0 1.0 1.0 0.0901924811619011 0.0790607116166092 +Proximal amyotrophy 5 12 1.9844038793643723 0.0472108339129315 4.718446601941747 13.856796116504857 0.6037658559324836 0.4972994712742096 2.2062025350790946 1.7602342703705265 0.8206757208003167 0.3130721595344946 1.0 1.0 1.0 0.1374615323876937 0.008785557350241 +Bilateral cryptorchidism 7 10 1.9807757429117 0.0476164282525684 2.6529126213592233 9.849514563106796 0.7102983026891413 0.4046694096755988 1.7935743620951357 1.043553840834269 0.9852608840174656 0.3101013475492273 0.1525522796012576 0.1114073342812727 0.2070995190727305 0.0193169154759243 0.0052134507581354 +Dysostosis multiplex 3 7 1.9765156690793824 0.0480964028628954 3.983009708737864 7.990291262135922 0.4150973501220912 0.1595724105588133 1.65382835361071 1.246316090990369 1.8479195153421644 0.2123242141003258 0.1348167495715124 1.0 0.0170518298819148 0.0014320459890063 0.0028145739091465 +Clumsiness 6 20 1.973452831453904 0.0484439935081137 6.75 20.57766990291262 0.9027704056640264 0.2559090219975202 2.4698423753801175 2.2221930931993956 1.527926415027724 0.282470536898918 0.287065986663278 0.2145132052110039 0.3777229935777695 0.0300192966842153 0.0089113675821019 +Abnormal elasticity of skin 11 52 1.9722028767778488 0.0485864514106295 12.949029126213592 61.342233009708735 0.3908434863184051 0.6206140883004606 4.691432392388869 5.29075607716294 0.8206735368420446 0.3519232728015974 0.0944619934499406 0.1813311010194401 0.0179719199144886 0.037498269976549 0.0436335804540684 +Furrowed tongue 2 5 1.9644610653808896 0.0494766471950871 1.9951456310679612 5.898058252427185 0.740908395172817 0.4209845919293222 1.2941150322346422 1.3862347258142311 0.8556489270277975 0.3009947920089302 1.0 1.0 1.0 0.0319451393300601 0.1645088237572309 +Slurred speech 3 7 1.9634067687461556 0.0495989279524908 2.45873786407767 8.864077669902912 0.5323927403653204 0.4147809462031548 1.4075891250208603 1.616351781434359 0.9973486618272436 0.2852319096618858 0.1756432640316061 0.1287528218161406 0.2372212797486779 0.0291459656321865 0.0446088038944012 +Symptomatic seizures 2 9 1.9602884495072863 0.0499620853023545 2.592233009708738 7.91747572815534 0.8003602116841944 0.3815595980603305 1.5434603237366336 0.6408318599381966 0.9316569091826736 0.2966211267450162 0.1227903182841607 0.0892490045576324 0.1677870330809631 0.0757571260003459 0.0618109910728358 diff --git a/msigdb_hp/metrics.json b/msigdb_hp/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..1ba87d871d5793c49d2777f439e06d81e46ca3b8 --- /dev/null +++ b/msigdb_hp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2812, + "annotations_size": 4507, + "title": "Average number of proteins per term", + "value": 21.251608608830708 +} \ No newline at end of file diff --git a/msigdb_hp/paths.json b/msigdb_hp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..90ea5b2a6e0fd2fd634a29ba28a2fe3da1513237 --- /dev/null +++ b/msigdb_hp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_hp/fragment/C428/C428_val_log2fc"} \ No newline at end of file diff --git a/msigdb_hp/result.tsv b/msigdb_hp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..272771ec315f26ad5f692f44b33cc790d09c9444 --- /dev/null +++ b/msigdb_hp/result.tsv @@ -0,0 +1,1724 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Mental deterioration 0.5443485899452021 3.9943996611096297 6.485838070524608e-05 0.2534750215728054 0.2757560362698564 90 Q9Y3I1,Q10713,P21964,P35637,Q9NXN4,Q8NHS3,P10644,O75503,P43243,Q03164,P06865,P36543,Q9BQE5,P22626,P16278,P61916,Q9Y287,Q9Y487,P18074,O95470,P31483,P50897,P21912,P03886,Q5JTZ9,O15118,P54802,Q14108,P04062,Q13501,Q06787,P07602,P42858,O75306,P17900 35 +Vascular skin abnormality 0.4599040045718569 2.9825445711289027 0.0028586302154693 0.999997507680182 0.2757560362698564 102 Q99829,P04066,O60216,Q13126,P21964,P10644,Q08J23,P36543,Q9C0B1,P07858,Q6UN15,P16278,P38435,Q9Y487,P18074,P01889,P06280,P51648,O75844,Q06330,O00462,P10619,P21912,Q4G0J3,P03886,Q14108,P04062,Q06124,Q14739,P40818,Q02750,Q15437,Q06136,O75306,Q07954 35 +Abnormal biliary tract morphology 0.714739839231466 2.9770393826546693 0.0029104662093129 0.999998028266205 0.2757560362698564 21 Q14739,P07602,P09601,P21266,Q14108,P04062 6 +Abnormal sternum morphology 0.4583680832178786 2.975604066132262 0.0029241211921133 0.9999981462878748 0.2757560362698564 100 O75718,O60216,Q96AY3,O96028,P08236,Q08J23,Q03164,P57740,P16278,Q7LGA3,P50402,Q9Y487,P55795,Q9UHX1,P21912,Q15555,Q9Y619,P61978,P04062,Q9BYW2,Q06124,P78318,Q14739,P98175,Q06787,Q9UJX6,Q02750,Q15437,P07437,P42356 30 +Biliary tract abnormality 0.6451589407919514 2.9496342867921927 0.0031815027878276 0.9999994209583324 0.2757560362698564 25 Q14739,P07602,P09601,P21266,O96028,Q14108,P04062 7 +Arthritis 0.6076842994981257 2.945112456884691 0.003228372999942 0.999999531539778 0.2757560362698564 35 P10321,Q14739,P14174,P01889,P06280,P28070,P21964,Q9UBS4,Q14108,P04062,O75844 11 +Cognitive impairment 0.4712407847750676 2.9104135232283075 0.0036095083734548 0.9999999164219509 0.2757560362698564 151 P42345,Q9Y3I1,Q10713,P21964,P35637,Q9NXN4,Q8NHS3,O75503,P40855,P43243,P10644,Q03164,P06865,P36543,Q9BQE5,P57740,P22626,P16278,P61916,Q9Y287,Q9Y487,P18074,O95831,O95470,P01889,P06280,Q9NZ08,P31483,O76024,P50897,P21912,Q969G3,Q8N0X7,P49327,Q9Y619,Q5JTZ9,O15118,P54802,Q14108,Q9Y263,P17900,P04062,Q6PGP7,P03886,Q13501,Q06787,O00429,P07602,P52701,P42858,Q15437,O75306,Q6DKK2,Q9BVA1,Q9Y2R0 55 +Subcutaneous nodule 0.7473230250306937 2.903185324844682 0.0036938797763994 0.9999999429387464 0.2757560362698564 18 O75874,P01889,P06280,Q15437,P35637,P48735,Q06124 7 +Pectus excavatum 0.5025622061117614 2.8886212977288293 0.0038693476205886 0.999999974202186 0.2757560362698564 72 O75718,O60216,Q08J23,Q03164,P57740,Q7LGA3,P50402,Q9Y487,Q9UHX1,P21912,Q15555,P61978,P04062,Q9BYW2,Q06124,P78318,Q06787,P98175,Q9UJX6,Q02750,Q15437,P07437,P42356 23 +Soft tissue sarcoma 0.6249777529083566 2.8675649843897366 0.0041364384653432 0.9999999922965108 0.2757560362698564 28 P21912,P52701,Q15392,Q969G3,Q02750,P49327,Q13126,Q15437,P10644,Q07954,Q06124 11 +Psychomotor deterioration 0.9026479757209588 2.7950549384378327 0.0051890896116582 0.999999999934444 0.2757560362698564 9 P50897,P07602,Q9Y487,P06865,Q03164 5 +Dementia 0.514738933038763 2.7817295361874637 0.0054070079884991 0.9999999999755772 0.2757560362698564 56 Q9Y3I1,P35637,P06865,P36543,P22626,P61916,Q9Y287,Q9Y487,P31483,P21912,P03886,Q5JTZ9,O15118,Q14108,P04062,Q13501,Q06787,P07602,P42858,P17900 20 +Increased bone mineral density 0.6646128486519134 2.758879771566046 0.0057999869196068 0.999999999995886 0.2757560362698564 22 Q15392,Q13126,P54802,Q14108,P04062 5 +Fibrous tissue neoplasm 0.701024708254022 2.6347030395652484 0.0084210921906038 1.0 0.2757560362698564 18 P21912,P52701,Q15392,Q969G3,P49327,Q13126,Q15437,P10644,Q07954 9 +Abnormality of the spleen 0.4336511975099552 2.6182503967313737 0.0088381924395732 1.0 0.2825087469869278 104 P15260,P14174,Q15392,P21964,O96028,P08236,P16278,P01889,P10619,O15118,P54802,Q14108,P04062,Q06124,Q14739,P07602,Q9Y285,P28070,Q15437,Q15904,O14936 21 +Blindness 0.481665346925067 2.582132151341626 0.0098191977222754 1.0 0.2892491773483367 68 P16278,Q96CU9,P21912,Q15555,O43676,P50897,P07602,P01889,Q969G3,O43505,O75306,Q8NHS3,P06865,Q9Y6M9 14 +Ascites 0.6181670912927624 2.549633658257517 0.0107836166781938 1.0 0.2917174211994184 23 P61916,Q01844,Q14739,O15118,P08236,P10644,Q14108,P04062,Q00059 9 +Hyperlipidemia 0.5874210280964162 2.54255220241741 0.0110046161453969 1.0 0.2917174211994184 25 Q92734,P50402,Q9UJS0,P31751,Q9Y285,O95470,P06280,P35573,P28070,P23786,O75844,P22830 12 +Myoclonus 0.4636832063816496 2.542078614973618 0.0110195385157159 1.0 0.2917174211994184 76 Q96CU9,P50897,O14773,P07602,P42858,Q969G3,Q14108,O75503,P00374,P04062,O14936,Q9UBX3,Q7L7X3 13 +Skin nodule 0.6279912011735034 2.5192294883503625 0.0117611973981033 1.0 0.2986692062155973 22 O75874,P01889,P06280,P35637,Q15437,P48735,Q06124 7 +Corneal opacity 0.5348978451952715 2.4972406306560955 0.0125163990632051 1.0 0.3082590741959862 42 P16278,P10619,O43505,Q06136,O96028,P08236,P04062,O75844 8 +Osteolysis 0.5936155277739381 2.480646480609963 0.0131144367318112 1.0 0.3160028889419692 24 O75874,Q14108,P04062,O75844,P48735 5 +Splenomegaly 0.4561726662737852 2.478380555716557 0.0131980292818152 1.0 0.3160028889419692 77 P15260,P14174,Q15392,P04066,P21964,P08236,P16278,P61916,P01889,P10253,O15118,P54802,Q14108,Q6PGP7,P04062,Q14739,P07602,P28070,Q15437,Q15904,O14936 21 +Mucosal telangiectasiae 0.8005571643782325 2.4689136810443952 0.0135523905190524 1.0 0.3160028889419692 10 Q15437,P10619,P21912,P06280 4 +Cherry red spot of the macula 0.8278224774379089 2.463468945620425 0.0137599814720617 1.0 0.3160028889419692 9 P16278,P10619,P07602,P06865 4 +Delayed cranial suture closure 0.5763018580764123 2.4619935675245173 0.0138167144723915 1.0 0.3160028889419692 25 Q32P28,O75718,Q9Y487,P36543,O75844 5 +Rigidity 0.5031854820745483 2.4504760145400457 0.0142667467413328 1.0 0.3188249003317571 50 P16278,Q96CU9,P07602,Q9Y287,Q15392,P04062,O14936 7 +Bulbar signs 0.7606188404354226 2.416752975528868 0.0156596404291065 1.0 0.3325307961631621 11 Q92734,P07602,P03886,P35637,P04062,P43243 6 +Broad based gait 0.64522053423629 2.37214789169724 0.0176850103778729 1.0 0.3639558985071845 19 Q03164,O14773,P98175,P04062 4 +Visual loss 0.5143815374395556 2.3665970805501684 0.0179524652715745 1.0 0.3666213474414612 44 P50897,P07602,O14773,P01889,P48449,O75306,Q8NHS3,O75503,P04439 9 +Disproportionate short stature 0.631256378347063 2.3645032097157896 0.0180542709057578 1.0 0.3666213474414612 20 P16278,Q7LGA3,Q32P28,Q14739,O75718,Q15392,O00116,Q03164,Q9UHX1,P42345 10 +Osteoarthritis 0.8060495201615535 2.364415179774413 0.0180585620439326 1.0 0.3666213474414612 9 O75844,Q14108,P04062 3 +Increased intracranial pressure 0.6657796156362407 2.357543608387651 0.0183962944513629 1.0 0.3715827980013929 17 P21912,P07602,P52701,P01889,Q969G3,Q9NZ08,P49327,Q15437,P10644 9 +Malignant neoplasm of the central nervous system 0.627808646584985 2.3424121534627975 0.0191595437659515 1.0 0.3820225575409217 20 P21912,Q15555,O75874,P07437,P48735,Q06124 6 +Pathologic fracture 0.7276621646647542 2.3377726070494695 0.0193990473478535 1.0 0.3820225575409217 12 Q13126,Q14108,O15270,P04062 4 +Enchondroma 0.767728580418696 2.3127579619737113 0.0207359502500668 1.0 0.3839991121964214 10 P48735,Q06124 2 +Neurodegeneration 0.5464443360790534 2.3033054988119477 0.021261660476419 1.0 0.3888821533369195 29 P42858,Q15165,P50995,P35637,Q5JTZ9,P08236,Q8NHS3,Q6DKK2,P17900,Q92804 10 +Lymphedema 0.7196652455724493 2.2964107628320636 0.021652406162969 1.0 0.3932722388766641 12 Q14739,P08236,P06280,Q06124 4 +Abnormality of the lymphatic system 0.419697402647906 2.29510223708878 0.0217272659153071 1.0 0.3932722388766641 125 P15260,O75874,P14174,Q15392,P21964,O96028,P08236,P16278,P01889,P10253,P48735,P10619,O15118,P54802,Q14108,Q6PGP7,P04062,Q06124,Q14739,P07602,P31751,Q9Y285,P28070,Q15437,Q15904,O14936 26 +Increased cerebral lipofuscin 0.952362379435221 2.2828892051998935 0.0224368955109954 1.0 0.4017502544861613 5 O14773,O75503,P50897 3 +Talipes equinovarus 0.4620197544932589 2.279432805989392 0.0226413500420423 1.0 0.4017502544861613 61 Q8TB36,Q9Y3I1,Q15392,Q8TD16,Q13363,P21964,Q96AY3,O96028,P08236,P36543,Q9Y487,Q53EZ4,Q9Y619,P61978,Q9BYW2,P98175,Q9UJX6,P40818,P04792,P42356 20 +Optic disc pallor 0.516220715885313 2.270338210487344 0.0231870703638539 1.0 0.4050547524414327 39 Q96CU9,Q9Y287,O43676,Q9Y6M9,Q9H061,O75306,Q8NHS3,O14936,P04439 9 +Melanocytic nevus 0.7271937062550576 2.24945133725567 0.0244837955440291 1.0 0.4245629067105075 11 Q15022,P21912,Q15437,Q96AY3,P10644,Q06124 6 +Goiter 0.8692968276061175 2.2485188454413425 0.0245431247796756 1.0 0.4245629067105075 6 Q15437,O75874,P48735 3 +Disproportionate short limb short stature 0.656588203550137 2.2440827396274083 0.0248270782935351 1.0 0.4270826025532935 16 Q32P28,Q7LGA3,Q14739,O75718,Q15392,O00116,Q03164,P42345 8 +Muscle stiffness 0.6121380297147941 2.241337379527045 0.025004229428243 1.0 0.4280223097756531 20 Q15392,P53985 2 +Abnormal thyroid morphology 0.525803826904478 2.2296936342843674 0.0257677887847116 1.0 0.4330910290642437 33 P21912,O75874,Q15437,P42892,P48735 5 +Abnormality of glycolipid metabolism 0.8199156403178696 2.2226682326715963 0.0262381795054127 1.0 0.4330910290642437 7 P07602,P06865,P06280 3 +Abnormal conjunctiva morphology 0.541912069178155 2.2205112795993966 0.0263840808655779 1.0 0.4330910290642437 26 P34897,O00462,P10619,P21912,Q14739,P02786,P01889,P18074,P04066,P06280,Q9NZ08,P49327,P28070,Q15437 14 +Reduced visual acuity 0.4015013408889826 2.2192057932930966 0.0264727271274356 1.0 0.4330910290642437 98 P16278,Q96CU9,P50897,P07602,O43676,P21912,Q15555,P01889,Q969G3,O43505,Q9H061,O75306,Q8NHS3,P06865,Q9Y6M9,P17900 16 +Central scotoma 0.7459376422485202 2.2075046670088456 0.0272788213058099 1.0 0.4344369174038354 10 Q9H061,O75306,Q8NHS3 3 +Pulmonary fibrosis 0.6481629358463283 2.194731331390187 0.0281828758407691 1.0 0.4472543007547417 16 P14174,P04062,P21266,P09601 4 +Pleural effusion 0.7688545578554699 2.192471837281475 0.0283454544646999 1.0 0.4482560114821144 9 Q14739,P14174,P01889,Q02750,Q9NZ08,P49327,Q06124 7 +Neoplasm by histology 0.3985165665742807 2.1856603372505106 0.0288404647073319 1.0 0.4544894211047027 91 Q01844,P21912,Q15555,O75874,Q15392,Q969G3,O43924,Q02750,Q13126,Q15437,Q6PGP7,P07437,Q9BYW2,P48735,Q06124,Q92804 16 +Neoplasm of the nervous system 0.496778294835567 2.182614566586068 0.0290642061564527 1.0 0.4564194325684065 43 Q01844,P21912,Q15555,O75874,Q969G3,O43924,Q15437,P07437,Q9BYW2,P48735,Q06124 11 +Posteriorly rotated ears 0.3957050549732523 2.170091088257052 0.0299999461730944 1.0 0.4662405427659882 94 Q99567,Q15392,Q13363,Q10713,O60216,O96028,Q08J23,P40855,Q7LGA3,P11233,O43924,O43505,P37268,Q9UHX1,Q15555,Q9Y619,P42892,P04062,Q9BW83,Q06124,P98175,Q02750,P07437,P23786 24 +Multiple enchondromatosis 0.8478577035910366 2.1601064331110904 0.0307644311326518 1.0 0.4672055951413906 6 P48735,Q06124 2 +Avascular necrosis 0.610855836956284 2.15532794699089 0.0311361803401108 1.0 0.4672055951413906 19 P01889,Q8IWS0,Q9NZ08,Q9Y619,Q14108,P04062,O75844,Q06124 8 +Abnormality of the alveolar ridges 0.8456645190082764 2.151012017543585 0.0314752511494536 1.0 0.4672055951413906 6 Q15392,O43924 2 +Thickened skin 0.4014765535037478 2.1505300352746186 0.0315133128295945 1.0 0.4672055951413906 89 Q14126,P04066,P48449,P40855,Q15800,P16278,P50402,Q96IJ6,P18074,P06280,P51648,O95721,O75844,P21912,Q15555,O15270,Q4G0J3,P04062,Q14739,P31751,Q02750,P28070,Q15437,Q06136,P07437,Q07954 26 +Prenatal movement abnormality 0.4720154950555335 2.1481586893405713 0.0317011512033806 1.0 0.4684494704053664 50 Q05639,P49588,P38606,O00429,Q8N9N2,Q16637,Q99567,Q70HW3,Q8TD16,Q13363,O60216,O96028,P40855,P04062,O75844,P51114 16 +Biliary cirrhosis 0.8441768230870667 2.1448377659364755 0.031965820508484 1.0 0.4700820647853548 6 Q14739,P09601,P21266 3 +Rhizomelia 0.7327980516742943 2.143420643578091 0.0320793369302123 1.0 0.4700820647853548 10 Q14739,O75718,Q15392,O00116,Q03164 5 +Sarcoma 0.4567019606167963 2.14241396687307 0.0321601849670378 1.0 0.4700820647853548 54 P21912,O75874,Q15392,Q13126,Q15437,P48735,Q06124,Q92804 8 +Abnormal pleura morphology 0.6372935407121383 2.1306764087011176 0.0331158099134307 1.0 0.4740213670112791 16 Q14739,P14174,P01889,Q02750,P08236,P36543,Q06124 7 +Abnormal pericardium morphology 0.7550529857720826 2.127793173224327 0.0333542356407079 1.0 0.4757200633945275 9 P14174,P01889,Q9NZ08,P49327,P47985,Q14108,P04062 7 +Cerebral palsy 0.7290325277814849 2.124970050282991 0.0335891120398266 1.0 0.4775587632917936 10 P48735,P98175,O75874 3 +Macrogyria 0.909849411565127 2.1184865193351774 0.0341338854045638 1.0 0.4818625598504517 5 Q15392,O43505 2 +Hypersplenism 0.8378277259808024 2.118439902505184 0.034137829529423 1.0 0.4818625598504517 6 Q14108,P04062 2 +Scotoma 0.6689461069046541 2.1175574793313334 0.0342125624921554 1.0 0.4818625598504517 13 Q9H061,O75306,Q8NHS3,P04439 4 +Abnormality of skull ossification 0.6852557913383819 2.116196590527987 0.0343280910810956 1.0 0.4819835093535772 12 Q32P28,O75844,P54802,Q14739 4 +Coarse hair 0.6299846464568817 2.0873602244584415 0.0368555846044971 1.0 0.507975901567182 16 Q9Y487,P54802,Q06124 3 +Periventricular white matter hyperintensities 0.7884508691431048 2.0851421747021988 0.0370563969567814 1.0 0.5081468434518405 7 O75503,P07602 2 +Short palpebral fissure 0.5160387884092168 2.0835947005380437 0.0371970494693005 1.0 0.5081468434518405 30 P98175,Q15555,P55795,Q9Y619,P07437,Q03164,O75844 7 +Cystic hygroma 0.788076711598554 2.0834939180331977 0.0372062255023535 1.0 0.5081468434518405 7 Q14739,Q02750,Q53EZ4,P61978,Q06124 5 +Renal dysplasia 0.7144271397147113 2.053046756362396 0.04006804304496 1.0 0.5269319968279751 10 O14936,O75306,O43505 3 +Abnormal oral frenulum morphology 0.6570825149192279 2.0525291426898775 0.040118265822439 1.0 0.5269319968279751 13 O43924 1 +Cardiovascular calcification 0.7384029567296558 2.049136895574918 0.0404487305717264 1.0 0.5269319968279751 9 O75844 1 +Cerebral inclusion bodies 0.6393901404613213 2.0483500427290453 0.0405257128373288 1.0 0.5269319968279751 14 P61916,P31483,Q9Y287,O15118,P04062,P22626 6 +Muscle abnormality related to mitochondrial dysfunction 0.5146382907266682 2.0387508275004516 0.0414749021622935 1.0 0.5356085502735158 28 Q96CU9,O43676,O75306,Q9UBX3,Q9Y2R0 5 +Cupped ear 0.669721929566735 2.033655670713711 0.0419863245977212 1.0 0.5369889848710754 12 Q15392 1 +Neoplasm of the pituitary gland 0.6291215277549995 2.032942046043256 0.0420583784467472 1.0 0.5369889848710754 15 P52701,O75874,P40818,Q969G3,Q9UBS4,P10644,P48735 7 +Retinopathy 0.5168734844003494 2.0193534841727883 0.0434504925857672 1.0 0.5439760280112587 25 Q15555,P01889,Q13363,P18074,Q9NZ08,P49327,Q9UKG1,P51648,O96028,Q8NHS3,O75306,P07437 12 +Aplasia hypoplasia involving the skeletal musculature 0.7316435927429847 2.0170101019791113 0.0436944591105226 1.0 0.5451317387648688 9 Q9Y487 1 +Joint contracture of the hand 0.4864178503477704 2.0095683282495247 0.0444768961551043 1.0 0.5476977348935932 39 Q15022,Q9BYW2,Q99567,P27635,Q15392,P18074,Q9UJX6,Q9Y619,P42892,O75844,P57740,P46109 12 +Limb girdle muscle weakness 0.5401131662539741 2.0034489720419115 0.0451291195036764 1.0 0.5542150997358853 23 Q13126,O14979,P07602 3 +Neuronal loss in central nervous system 0.6629700076180515 1.9975515621593496 0.0457652990753498 1.0 0.5580061547523576 12 P35637,O15118,P07602,P04062 4 +Nasogastric tube feeding in infancy 0.7275582298433414 1.9975384473865372 0.0457667222000039 1.0 0.5580061547523576 9 P61978,Q92734,Q9UHX1,P07602 4 +Aspiration 0.6764756321589183 1.9893727218950752 0.0466600782207711 1.0 0.560332224893801 11 O15344,P06865,P43243,P42356,P17900 5 +Abnormal caudate nucleus morphology 0.7660031917268714 1.985723781127944 0.047064002915655 1.0 0.560332224893801 7 O75306,P42858 2 +Proximal amyotrophy 0.6605175407681338 1.9844038793643723 0.0472108339129315 1.0 0.560332224893801 12 P50402,Q16637,O14979,Q9BQP7,P35637 5 +Bilateral cryptorchidism 0.6998656060932665 1.9807757429117 0.0476164282525684 1.0 0.560332224893801 10 P78318,P27635,Q07864,O43924,P48449,P36543,P37268 7 +Dysostosis multiplex 0.7639362672671042 1.9765156690793824 0.0480964028628954 1.0 0.5630402278001807 7 P54802,P10619,P08236 3 +Clumsiness 0.5713918716301765 1.973452831453904 0.0484439935081137 1.0 0.5656401003654633 20 O14773,P07602,P42858,Q15067,O75503,P31483 6 +Abnormal elasticity of skin 0.447565984863692 1.9722028767778488 0.0485864514106295 1.0 0.5658375620354197 52 Q15555,Q9Y487,Q13126,Q53EZ4,Q15904,P04062,P36543,O75844,P07437,Q9UHX1,Q06124 11 +Furrowed tongue 0.8706798460790081 1.9644610653808896 0.0494766471950871 1.0 0.5746590444264175 5 Q15437,P21912 2 +Slurred speech 0.7609972247811021 1.9634067687461552 0.0495989279524908 1.0 0.5746590444264175 7 P16278,Q9Y487,Q8N0X7 3 +Symptomatic seizures 0.719766393536811 1.9602884495072863 0.0499620853023545 1.0 0.5773823550197745 9 P53985,P31751 2 +Bone pain 0.5571823118488772 1.9550518751644528 0.050576947678143 1.0 0.5829931027759351 21 P07602,Q14108,P04062,P48735,Q06124 5 +Abnormal pulmonary interstitial morphology 0.5067929013211677 1.9520824760312896 0.050928413413942 1.0 0.5837234093293854 26 P14174,Q9Y285,P09601,P21266,Q14108,P04062 6 +Prematurely aged appearance 0.4861356199502108 1.950974217294683 0.0510601128996885 1.0 0.5837234093293854 35 Q13126,Q9Y487,O75844,Q06124 4 +Abnormality of the ribs 0.445413016947483 1.950148986322284 0.0511583640304209 1.0 0.5837234093293854 52 P16278,Q32P28,Q14739,O75718,Q9Y619,O96028,P54802,Q03164,O75844,Q06124 10 +Abnormal retinal artery morphology 0.5671570043720298 1.9451982078340564 0.051751127467261 1.0 0.5880315298853708 20 P16278,P10619,P07602,P06865,P17900 5 +Abnormal circulating cholesterol concentration 0.5008402744789534 1.944818095817821 0.0517968753859534 1.0 0.5880315298853708 29 P61916,P50402,Q14739,P07602,P42858,Q15392,Q15904,Q15800,P57740,Q8N511 10 +Retinal dysplasia 0.7960905004353467 1.943001744027768 0.0520159475952621 1.0 0.589034863848861 6 O43924,O43505 2 +Hypotension 0.5551685672618341 1.9412514632383384 0.0522277836468767 1.0 0.5898698941356303 21 P07602,O43772,P04062 3 +Abnormal cartilage morphology 0.6665368830681636 1.9375403203095591 0.052679329621744 1.0 0.5898698941356303 11 P48735,Q9UHX1,O75874,Q06124 4 +Epiphyseal stippling 0.6904978219895106 1.9339880802472549 0.0531145934108916 1.0 0.5898698941356303 10 Q14739,O00116,P08236,P10644,P40855 5 +Abnormal muscle fiber morphology 0.4299311926410843 1.930025691293337 0.0536036545572009 1.0 0.5898698941356303 61 Q70HW3,O14979,P35637,P43243,P13807,P22626,P50402,O43676,O95831,Q9BQP7,P31483,P51114,Q9H2D1,P03886,P61978,Q13501,O75648,Q5JPH6,P23786 19 +Redundant neck skin 0.7926758753154286 1.9285046071074272 0.0537923917516018 1.0 0.5898698941356303 6 Q9Y487,P36543 2 +Abnormality of corneal stroma 0.6644315121709833 1.9265246919595775 0.0540388917524514 1.0 0.5898698941356303 11 P10619,P04062,O43505 3 +Melanoma 0.5945060488992884 1.9260475307849971 0.0540984392282908 1.0 0.5898698941356303 17 P21912,P11802,P18074,Q99496,Q15437,P49959,P19447,P53634,Q9H1A4,Q06124 10 +Breast carcinoma 0.6007368867925026 1.91209337952088 0.0558642178759758 1.0 0.5898698941356303 16 Q15437,O75874,P48735 3 +Dolichocephaly 0.50111392196102 1.908018407801364 0.0563888371498535 1.0 0.5898698941356303 26 Q9BYW2,Q9UJX6,Q13363,P61978,O96028,O95721,P40855,Q03164,P42356 9 +Abnormality of upper limb joint 0.3776847655709129 1.907183151489652 0.056496874499208 1.0 0.5898698941356303 95 Q99567,Q15392,Q13363,O60216,Q96AY3,O96028,P10644,Q03164,P57740,P16278,Q7LGA3,Q15022,P50402,P27635,P18074,O75844,P37268,P46109,Q9Y619,P42892,Q9BYW2,Q06124,Q9UJX6,Q02750,P23786 25 +Enlarged thorax 0.6073673798904209 1.905256822598234 0.0567466951033419 1.0 0.5906636370225455 15 Q32P28,Q14739,Q02750,P08236,O75844,Q06124 6 +Metatarsus adductus 0.6441200384331636 1.8960397868026808 0.057954783646692 1.0 0.5981184523923083 12 Q15392,O96028,P08236 3 +Stillbirth 0.6440656302847703 1.8957452778523896 0.0579937350111912 1.0 0.5981184523923083 12 O75844,Q14739,P04062 3 +Decreased activity of mitochondrial complex i 0.4976318461077565 1.891830874438812 0.0585135182477987 1.0 0.6007299014643025 27 Q96CU9,O43676,Q70HW3,O75306,Q9UBX3 5 +Postnatal growth retardation 0.4275025955769772 1.890619116280461 0.0586752065499203 1.0 0.6010208089102065 59 O14646,Q13363,O60216,O96028,P08236,Q08J23,P10644,P36543,Q03164,Q9Y487,P27635,O75179,Q969G3,Q4G0J3,Q96ST3,Q06124,Q02750,O14936,P17900 19 +Abnormality of the supraorbital ridges 0.5692894983183882 1.8864666452339571 0.0592320990671491 1.0 0.6012914379253296 19 Q15022,P98175,Q8IWS0,Q02750,P38159,Q08J23,P40855,Q6PGP7 8 +Contractures of the joints of the upper limbs 0.4265068098766753 1.8855223061596011 0.0593593557856613 1.0 0.6012914379253296 60 Q7LGA3,Q15022,P50402,Q9BYW2,P37268,Q99567,P27635,Q15392,P18074,Q9UJX6,Q9Y619,P35637,Q96AY3,P23786,P42892,O75844,P57740,P46109 18 +Increased susceptibility to fractures 0.4513739787392035 1.883242803754471 0.0596674707110302 1.0 0.6012914379253296 48 Q32P28,Q14739,O75874,O75718,O15270,Q13126,Q14108,P04062,P48735 9 +Hypoglycemic seizures 0.7227844004834912 1.878642187669439 0.0602933666055101 1.0 0.6012914379253296 8 P53985,P31751 2 +Diffuse white matter abnormalities 0.8489914965940116 1.8781607935019833 0.0603591718146416 1.0 0.6012914379253296 5 O14936,O75306 2 +Low set posteriorly rotated ears 0.4238239983768014 1.8778086375530143 0.0604073482244826 1.0 0.6012914379253296 63 Q15022,P98175,Q15555,Q15392,Q13363,O43924,Q02750,O60216,Q10713,P16435,O96028,Q08J23,P40855,P04062,P37268,P07437,Q9BW83,Q06124 18 +Knee flexion contracture 0.510564177556784 1.8765438562296364 0.060580638486549 1.0 0.6012914379253296 24 Q7LGA3,P21912,Q86XL3,Q8TD16,O75477,Q96AY3,P36543,P37268,P23786 9 +Abnormality of head blood vessel 0.5342598078281763 1.8761296219741648 0.0606374830470717 1.0 0.6012914379253296 22 P16278,P10619,P07602,P06865,P17900 5 +Abnormal morphology of the conjunctival vasculature 0.7219398742466752 1.8747058992597083 0.060833194876936 1.0 0.6012914379253296 8 P18074,P10619,P04066,P06280 4 +Abnormal circulating lipid concentration 0.4202023064920069 1.8659608269107488 0.0620468463294612 1.0 0.6047368566245901 66 Q92734,Q9UJS0,Q15392,Q03252,P49748,P40855,Q15800,P57740,P61916,P50402,O95470,P06280,O75844,P37268,Q8N511,O43772,O75648,Q14739,P07602,Q16836,P31751,P42858,Q9Y285,P35573,P28070,Q15904,P23786,P22830 28 +Abnormal erythrocyte sedimentation rate 0.7774946647362275 1.863794181957373 0.0623506131059523 1.0 0.6047368566245901 6 P01889,P15260,P28070 3 +Anencephaly 0.607078107835337 1.862713940087809 0.0625025235506999 1.0 0.6047368566245901 14 P21964,O43505 2 +Undetectable electroretinogram 0.9533682340235168 1.8620538757450265 0.0625954965481754 1.0 0.6047368566245901 4 P50897,O43924 2 +Raynaud phenomenon 0.7378741330827959 1.8596437321873929 0.0629359477152662 1.0 0.6047368566245901 7 O75844 1 +Retinal hemorrhage 0.7762363580708188 1.8584119837621529 0.0631105317913891 1.0 0.6047368566245901 6 Q9Y487 1 +Meningioma 0.7184180214513325 1.858273948403999 0.0631301213995616 1.0 0.6047368566245901 8 Q15437,P21912 2 +Abnormal macrophage morphology 0.8434747394396683 1.8560976450252191 0.0634396413677378 1.0 0.6047368566245901 5 P16278,O15118,P15260 3 +Progressive visual loss 0.5537562643416176 1.855294879953929 0.0635541289666894 1.0 0.6047368566245901 20 O14773,O75306,P50897,O75503 4 +Hemianopia 0.7175014858998716 1.8539932286267649 0.0637401287529466 1.0 0.6047368566245901 8 P03886,Q9BVA1,Q969G3 3 +Hemorrhage of the eye 0.6740813164733903 1.8514500447249784 0.0641048351546791 1.0 0.6047368566245901 10 Q9Y487 1 +Abnormal placenta morphology 0.6965499980565484 1.8484362668904433 0.06453925627611 1.0 0.6047368566245901 9 P16278,O75844 2 +Chronic pulmonary obstruction 0.7729786012349078 1.8444643879193916 0.0651154911700138 1.0 0.607805426284857 6 P06280,P09601 2 +Central nervous system cyst 0.4552849217971437 1.8437164475704175 0.0652244747464889 1.0 0.607805426284857 45 Q99567,Q9Y487,Q9Y285,Q969G3,O43505,O96028,P07437,P36543,Q9UHX1,P23786,Q9C0B1 11 +Progressive neurologic deterioration 0.5624929876087942 1.8418417876855344 0.0654982956038243 1.0 0.607805426284857 19 P16278,P07602,Q9Y287,P54802,P04062 5 +Broad nasal tip 0.4469653598414363 1.8398552242525037 0.0657894952018693 1.0 0.607805426284857 48 P16278,Q7LGA3,Q9Y487,O95831,O43924,Q969G3,P35573,Q96GM5,P61978,P10644,P36543,Q9UHX1,O14936,P10586 14 +Underdeveloped supraorbital ridges 0.6715951918250748 1.8388908527779044 0.065931241484832 1.0 0.607805426284857 10 P98175,Q02750,Q6PGP7,Q08J23,P40855 5 +Generalized hyperkeratosis 0.8387163542823151 1.837031989217621 0.0662051730979524 1.0 0.607805426284857 5 O75844,Q15437,P21912 3 +Abnormal sacrum morphology 0.4906727922646032 1.8369587448411135 0.0662159859359576 1.0 0.607805426284857 27 Q9BYW2,Q14739,Q9UJX6,P01889,Q13363,P04066,P61978,O96028,Q08J23,Q03164 10 +Pedal edema 0.7137586623201174 1.8364933193016784 0.0662847292537454 1.0 0.607805426284857 8 Q9UJX6,Q14108,P10644,P04062,Q9BYW2 5 +Hamartoma 0.5613336814191133 1.8342120513652884 0.0666225232060377 1.0 0.607805426284857 19 P48735,O43924,O75874,Q15437 4 +Telangiectasia 0.4870360552175349 1.8338763009985604 0.0666723582069155 1.0 0.607805426284857 29 P10619,P21912,P06280,Q15437,O75306 5 +Neoplasm of the thyroid gland 0.5501805485525599 1.8311812188293408 0.067073499013974 1.0 0.607805426284857 20 P21912,P52701,Q969G3,P49327,Q15437,P10644,P42892 7 +Abnormality of the shoulder girdle musculature 0.4864101065552143 1.8288201582277528 0.0674265541146994 1.0 0.607805426284857 29 P50402,P07602,Q9Y487,O14979,Q8TD16,Q13501,Q06124 7 +Low frustration tolerance 0.6922124678115722 1.8273982316942168 0.0676399150311422 1.0 0.607805426284857 9 Q03164,P04062 2 +Delayed menarche 0.7679381945268424 1.8228477054635976 0.0683264601140645 1.0 0.6122213831691625 6 O75844 1 +Micromelia 0.5377874691713098 1.8214009633830988 0.0685459288460095 1.0 0.6129692486288987 21 Q14739,O75874,O75718,Q15392,P48735,Q9UHX1 6 +Abnormality of circulating adrenocorticotropin level 0.6903968364352914 1.8185790911412385 0.0689756701564816 1.0 0.6155907829609164 9 P16435,P40818,Q969G3,P10644 4 +Limb ataxia 0.5580703531742888 1.812707436781708 0.0698769568677437 1.0 0.6164417649525225 19 Q8IV08,Q14108,P04062 3 +Excessive wrinkled skin 0.6888116668511497 1.8108731906915032 0.0701604834045119 1.0 0.6164417649525225 9 Q9Y487,Q06124,P36543 3 +Intracellular accumulation of autofluorescent lipopigment storage material 0.964768683274024 1.810740501283635 0.0701810302833965 1.0 0.6164417649525225 2 O75503 1 +Abnormality of the pituitary gland 0.4199602083260478 1.807771702136287 0.0706420397067937 1.0 0.6164417649525225 59 O75874,Q07864,Q14746,P10644,Q03164,P57740,Q96IJ6,Q9BUK6,P48735,Q9UHX1,O76024,Q969G3,P16435,Q96ST3,Q06787,P52701,Q9Y285,P40818,Q99496,Q9UBS4,P42356 21 +Dermal atrophy 0.4890970696518979 1.8056306687627284 0.070976048850633 1.0 0.6164417649525225 25 Q07954,Q15392,P40818,P18074,P10644,O75844,P53634 7 +Abnormality of the nasal tip 0.3763635162273103 1.805589846442688 0.0709824298417831 1.0 0.6164417649525225 89 P16278,Q06787,Q9Y487,Q969G3,O43924,Q9UHX1,P38159,P35573,P21964,Q53EZ4,P61978,P42892,P36543,Q03164,O75844,O14936 16 +Kyphosis 0.3867351949244331 1.8028762334042563 0.0714076542966326 1.0 0.6164417649525225 128 Q8TB36,Q99567,Q13363,Q8TD16,P04066,Q96AY3,O96028,P08236,P10644,P36543,P57740,P16278,Q7LGA3,P50402,Q9Y487,P18074,P01889,Q9BQP7,P51648,O75844,Q9UHX1,P21912,Q8N0X7,Q8IWS0,Q14108,P04062,Q9BYW2,Q96ST3,Q06124,Q32P28,Q14739,P42858,Q5KU26,Q9UJX6,P40818,Q02750,O94992,Q15437,Q96PZ0 39 +Neoplasm of the endocrine system 0.4686296045854524 1.799603448858658 0.0719232761275356 1.0 0.6164417649525225 35 P21912,P52701,O75874,P40818,Q969G3,Q99496,P49327,Q15437,Q9UBS4,P10644,P42892,P48735 12 +Progressive cerebellar ataxia 0.4765870480763071 1.7995563569149924 0.0719307175846106 1.0 0.6164417649525225 32 Q96CU9,O14773,Q9Y487,Q9Y619,P35637,O75306 6 +Neck muscle weakness 0.5960728115782978 1.7987227244001978 0.0720625524136964 1.0 0.6164417649525225 14 P07602 1 +Upper limb spasticity 0.762025020190795 1.797431408630944 0.0722671582109404 1.0 0.6164417649525225 6 P35637 1 +Abnormal saccadic eye movements 0.5342612114662658 1.7969284344824197 0.0723469818436481 1.0 0.6164417649525225 21 Q8IV08,O14773,P04062 3 +Limb joint contracture 0.3801595520382762 1.7929149756173872 0.0729865203824988 1.0 0.6164417649525225 87 Q99567,Q15392,Q8TD16,O75477,P35637,Q96AY3,Q08J23,P36543,P57740,Q7LGA3,Q15022,P50402,P27635,O75844,P37268,P46109,P21912,Q8IWS0,Q9Y619,P42892,Q9BYW2,Q9UJX6,Q86XL3,P23786 24 +Horizontal nystagmus 0.5329499296245792 1.787814825404637 0.0738058881854277 1.0 0.6164417649525225 21 Q9H061,O14773,P04062 3 +Pericardial effusion 0.8261357834697987 1.7864696162845075 0.0740232525214752 1.0 0.6164417649525225 5 Q14108,P04062 2 +Acute coronary syndrome 0.5719028396032328 1.7852533061881684 0.0742202390309159 1.0 0.6164417649525225 17 O75844,P01889,Q06124 3 +Neoplasm of the skin 0.4697480900899179 1.784728186960746 0.0743054165915626 1.0 0.6164417649525225 34 P21912,P52701,Q07954,P18074,Q969G3,Q99496,P49327,Q15437,Q06136,P10644,P53634 11 +Urinary glycosaminoglycan excretion 0.721195667909875 1.7841245289852037 0.0744034322983229 1.0 0.6164417649525225 7 P16278,P54802,P08236 3 +Hirsutism 0.4183677767622643 1.781912162915129 0.0747635567686226 1.0 0.6164417649525225 57 P16278,Q9BYW2,Q15555,P27635,P40818,Q969G3,O60216,Q96GM5,P16435,Q06136,P54802,P08236,P10644,Q9Y263,P07437,Q03164,P53634,Q9BW83 18 +Increased serum pyruvate 0.4822553666657649 1.781808357011246 0.0747804889917753 1.0 0.6164417649525225 28 Q96CU9,P21912,O43676,Q70HW3,O75306,Q9BWD1,Q5JRX3 7 +Abnormal light and dark adapted electroretinogram 0.7583300042596876 1.781518655115231 0.0748277600712095 1.0 0.6164417649525225 6 P50897,Q15555 2 +Abnormal full field electroretinogram 0.7583300042596876 1.781518655115231 0.0748277600712095 1.0 0.6164417649525225 6 P50897,Q15555 2 +Slow decrease in visual acuity 0.7019695920722889 1.7811764564584978 0.0748836285612482 1.0 0.6164417649525225 8 P03886,O75306,Q969G3,O00429 4 +Polymicrogyria 0.4085472203391531 1.7797905880439753 0.0751102385142259 1.0 0.6166153824838184 70 Q01105,Q15392,Q8TD16,Q10713,Q96N66,Q08J23,P40855,P36543,Q9Y487,O43505,O95721,P37268,Q8WXW3,Q7L7X3,P07437,Q9BVA1,P42356,P23786,Q96C86,P42345 20 +Abnormal atrioventricular conduction 0.6217730179282663 1.7743661667918953 0.0760026024101205 1.0 0.6223921085959737 12 P06280,O43772,Q06124 3 +Myositis 0.6809924858682155 1.7727785168143435 0.0762654145939774 1.0 0.6223921085959737 9 P01889,Q9NZ08,P22626,P28070 4 +Pulmonary infiltrates 0.7182645191052258 1.770795586923777 0.0765947000729987 1.0 0.6223921085959737 7 P01889,Q9NZ08,P15260,P04062 4 +Thyroid carcinoma 0.6065364383091181 1.770553864094509 0.0766349197316365 1.0 0.6223921085959737 13 P21912,Q969G3,P49327,Q15437,P10644 5 +Poor head control 0.4159812306858769 1.7690524092470483 0.0768851288625191 1.0 0.6223921085959737 60 P21912,Q96CU9,P07602,O43676,Q5KU26,O94992,P03886,Q9Y6M9,O75306,O95721,P06865,P00374,Q8N183,O14936,Q6IA86,P17900 16 +Visual field defect 0.4559987447566562 1.7690052366020212 0.0768930006985448 1.0 0.6223921085959737 41 Q15555,Q9Y287,P01889,Q969G3,Q9H061,O75306,Q8NHS3,P04439 8 +Limited hip movement 0.5909573248874458 1.768851493243029 0.076918660858211 1.0 0.6223921085959737 14 Q7LGA3,Q8TD16,Q96AY3,Q9BYW2,O75844 5 +Lymphangioma 0.95266903914591 1.7613439310148524 0.0781802087577281 1.0 0.6236428334001428 2 P48735 1 +Visceral angiomatosis 0.95266903914591 1.7613439310148524 0.0781802087577281 1.0 0.6236428334001428 2 P48735 1 +Hemangiomatosis 0.95266903914591 1.7613439310148524 0.0781802087577281 1.0 0.6236428334001428 2 P48735 1 +Skin ulcer 0.4816295256066182 1.7555100391709264 0.0791721049872515 1.0 0.6282195020731388 26 O75874,P01889,O15270,P04062,P48735 5 +Neoplasm of the breast 0.5161934671289865 1.7474010348405755 0.0805677981086796 1.0 0.6356222910805633 22 P21912,P52701,O75874,Q99496,P49327,Q15437,P10644,P48735 8 +Loss of speech 0.5363865257091213 1.7376819188611723 0.082266876411077 1.0 0.6400381874285864 20 P61916,P50897,P07602,Q5JTZ9,O15118,P17900 6 +Gonadal neoplasm 0.5145562203860596 1.7356651534850664 0.0826230583666303 1.0 0.6400381874285864 22 Q01844,O75874,Q9UJX6,P10644,Q9BYW2,P48735 6 +Genital neoplasm 0.4688349307254129 1.7344091239670407 0.0828455173391622 1.0 0.6400381874285864 32 Q01844,P21912,P52701,O75874,Q07864,Q9UJX6,Q15437,P10644,Q9BYW2,P48735 10 +Premature skin wrinkling 0.5638023140729223 1.734364405507173 0.0828534464928847 1.0 0.6400381874285864 17 O75844,Q9Y487,Q06124 3 +Entropion 0.6500302994126758 1.7293128579780654 0.0837531166163165 1.0 0.643058426899044 10 O75844,P01889,P30153,P36543 4 +Clonic seizure 0.8105351139353418 1.7234663847345666 0.0848042190189013 1.0 0.6467880979942439 5 P07602 1 +Abnormal visual electrophysiology 0.449034244996858 1.7222878790968863 0.0850173823024718 1.0 0.647252266954798 42 O14773,Q15555,P50897,P07602,O43924,O75503 6 +Fluctuations in consciousness 0.7441020867822163 1.7200300578767005 0.0854269779846748 1.0 0.6481807908702514 6 P03886,O75306,Q9UJS0,P04062 4 +Achilles tendon contracture 0.6462511630822305 1.7099949905645824 0.0872667993881464 1.0 0.6586583359146422 10 Q8TD16,Q08J23 2 +Abdominal distention 0.5672039016183235 1.7075129982647683 0.0877267439188433 1.0 0.6586583359146422 16 O75648,Q01844,P07602,P04062,P42345 5 +Abnormal activity of mitochondrial respiratory chain 0.4432213503075196 1.7065707160723451 0.0879018719939757 1.0 0.6586583359146422 44 P21912,Q96CU9,O43676,Q70HW3,O75306,Q9UBX3,Q9Y2R0 7 +Focal t2 hyperintense brainstem lesion 0.577779175057459 1.6915416188105914 0.0907334059928735 1.0 0.6690079221721776 14 Q96CU9,O43676,P03886,O75306,Q9Y6M9 5 +Ragged red muscle fibers 0.5645170541483266 1.6909635477789315 0.0908437648922504 1.0 0.6690079221721776 16 O75648,Q70HW3,O95831,Q9BQP7,P03886,Q9H2D1 6 +Hyperconvex nail 0.6989688769717448 1.682641921517002 0.0924444311262924 1.0 0.6765289803467165 7 O96028,P42892 2 +Joint stiffness 0.4283031925778708 1.681554677199366 0.0926552254772536 1.0 0.6765289803467165 49 P16278,O76024,Q15022,P50402,O75874,P01889,P18074,O60216,Q96AY3,P51648,P54802,P08236,O75844,P48735 14 +Vascular neoplasm 0.4601995754329777 1.680836582653278 0.0927946607576397 1.0 0.6765289803467165 33 Q7LGA3,P10619,P21912,O75874,Q9UJX6,Q02750,Q15437,O96028,Q9BYW2,P48735,Q9UHX1,P42345 12 +Poor eye contact 0.4574197440418873 1.6782544005324227 0.093297445800099 1.0 0.6769898144825428 34 Q06787,Q96CU9,O43676,Q5KU26,Q9UHX1,P03886,O75306,Q8N183,Q9Y6M9 9 +Decreased muscle mass 0.5691824186186065 1.6773800387027908 0.0934681901958682 1.0 0.6769898144825428 15 Q9Y487,Q9Y285,O96028 3 +Abnormality of the pulmonary veins 0.7339896787288664 1.6761255412403877 0.0937136048264475 1.0 0.6769898144825428 6 Q15392 1 +Pituitary adenoma 0.616475263279657 1.6723564317404884 0.0944540579440111 1.0 0.6769898144825428 11 O75874,P40818,Q9UBS4,P10644,P48735 5 +Poor wound healing 0.7328474288778011 1.6711560692931926 0.0946908549132534 1.0 0.6769898144825428 6 O15270,P04062 2 +Neonatal hypoglycemia 0.616244762142618 1.671120393452936 0.0946979000028953 1.0 0.6769898144825428 11 Q16836,P31751,Q9UJX6,O43772,Q9UKG1,Q9BYW2 6 +Conjunctival hamartoma 0.9306049822064086 1.671005087318466 0.0947206729644949 1.0 0.6769898144825428 2 Q15437 1 +Follicular thyroid carcinoma 0.9306049822064086 1.671005087318466 0.0947206729644949 1.0 0.6769898144825428 2 Q15437 1 +Generalized muscle weakness 0.4625515836994911 1.6638050294298103 0.0961513985877942 1.0 0.6769898144825428 31 P21912,P42858,Q15165,P50995,P35637,P10253,Q5JTZ9,P07737,P43243,Q13501,Q92804 11 +Primitive neuroectodermal tumor 0.5665574748703708 1.6615511866899542 0.0966027976099432 1.0 0.6769898144825428 15 P21912,Q15555,Q9UJX6,P07437,Q9BYW2,Q06124 6 +Short nail 0.7952627532383951 1.661480532379023 0.0966169755933543 1.0 0.6769898144825428 5 Q9Y487 1 +Decerebrate rigidity 0.8997326387159028 1.660158303634694 0.096882610342126 1.0 0.6769898144825428 4 P07602 1 +Abnormality of the plantar skin of foot 0.4474701558051837 1.6596049722520732 0.0969939474059389 1.0 0.6769898144825428 39 P21912,Q96IJ6,Q9Y487,Q15437,P61978,Q06136,O95721,P07858 8 +Dilated fourth ventricle 0.4551244140090688 1.6583364445622724 0.0972495768896251 1.0 0.6769898144825428 34 Q99567,Q9Y487,Q969G3,O14936,O43505,P07437,P36543,P23786,Q9C0B1 9 +Neoplasm of the respiratory system 0.6000893249852414 1.6549990059530932 0.0979246995472316 1.0 0.6769898144825428 12 Q01844,P52701,Q9UJX6,Q9BYW2,P30154 5 +Coarse facial features 0.4066879453589454 1.651507404706332 0.0986350100251265 1.0 0.6776646191817763 56 P04066,P38159,P08236,Q9C0B1,P16278,Q7LGA3,P18074,O95831,P06280,P10619,Q969G3,Q8IWS0,P61978,P54802,Q9Y263,Q9BYW2,Q06787,Q9UJX6,Q02750,Q96GM5 20 +Abnormally lax or hyperextensible skin 0.4563647742468391 1.647961427212027 0.0993605867836366 1.0 0.677783123411261 33 Q15555,Q9Y487,Q53EZ4,Q15904,P04062,P36543,P07437,Q9UHX1,Q06124 9 +Severe short stature 0.5129026550036389 1.6476245942713588 0.0994297303375424 1.0 0.677783123411261 21 P16278,Q15392,P10619,P21912 4 +Hallucinations 0.4348178380775134 1.647134220718827 0.0995304606388485 1.0 0.677783123411261 45 P50897,P07602,P42858,Q8N0X7,P35637,Q6DKK2,O75503,P04062,Q9BQE5 9 +Abnormal macular morphology 0.480224549300023 1.6469258321245477 0.0995732915161571 1.0 0.677783123411261 24 Q8NHS3,P04062,P50897 3 +Endocarditis 0.7912361952262157 1.6450895904311642 0.0999513369555775 1.0 0.677783123411261 5 P01889,Q9NZ08,P10644,P04062 4 +Airway obstruction 0.5843933695408307 1.6446699649320038 0.1000378899226985 1.0 0.677783123411261 13 O75844,P06280,P09601 3 +Prominent nasolabial fold 0.7898955811507264 1.6396280128033398 0.1010825349363688 1.0 0.677783123411261 5 Q9Y487 1 +Abnormality of the nasolabial region 0.7898955811507264 1.6396280128033398 0.1010825349363688 1.0 0.677783123411261 5 Q9Y487 1 +Abnormal middle phalanx morphology of the hand 0.7253636123288267 1.638546937895185 0.1013076509676906 1.0 0.677783123411261 6 Q03164,Q9UHX1 2 +Bruising susceptibility 0.4675670145381211 1.637211698557106 0.1015862435054049 1.0 0.677783123411261 25 Q13126,Q14108,P04062 3 +Papillary thyroid carcinoma 0.6890524624090956 1.6370709396716363 0.1016156478133936 1.0 0.677783123411261 7 Q15437 1 +Mitochondrial myopathy 0.5108225811786045 1.632990164270756 0.1024710653135658 1.0 0.677783123411261 21 O75306,Q96CU9,O43676 3 +Diaphyseal thickening 0.9195729537366548 1.62573008247247 0.1040070876423377 1.0 0.6829264876812042 2 P08236 1 +Abnormal endocardium morphology 0.5809458925074561 1.6249530833933492 0.1041725560395598 1.0 0.6829264876812042 13 P01889,Q9NZ08,P06280,P10644,P04062,Q06124 6 +Alveolar ridge overgrowth 0.9192170818505412 1.6242686231116752 0.1043184907137955 1.0 0.6829264876812042 2 Q15392 1 +Tongue nodules 0.91921708185054 1.624268623111671 0.1043184907137964 1.0 0.6829264876812042 2 O43924 1 +Venous thrombosis 0.5662589556039048 1.6235544904107155 0.1044709249264905 1.0 0.6829264876812042 14 O75874,P01889,P40818,Q9NZ08,P10644,P48735 6 +Photophobia 0.4474178203332858 1.6231714593130138 0.1045527571555426 1.0 0.6829264876812042 36 Q15555,P07602,Q9Y287,Q13432,P01889,Q9NZ08,P48449,Q6P4Q7,P04439 9 +Neoplasm of the oral cavity 0.6283372370083333 1.617980821366692 0.1056667308946239 1.0 0.6854621068833323 10 Q969G3,O43924,P52701,P49327 4 +Hypocholesterolemia 0.6847394062132246 1.6171961044399492 0.1058359569659321 1.0 0.6854621068833323 7 Q15800,P07602 2 +Abnormality of the ovary 0.4032546820086713 1.6138504829852316 0.1065598613977325 1.0 0.6864316341379901 56 O75874,Q03252,P10644,O75312,P57740,Q9H1A4,O75844,P48735,P21912,P49327,P16435,Q5JTZ9,Q9BYW2,Q9BW83,Q06124,Q01844,Q06787,P52701,P31751,P40818,Q15437 21 +Abnormality of skin adnexa physiology 0.4389034668893432 1.6106926367559204 0.1072467313812095 1.0 0.688651771655254 41 P21912,Q96IJ6,P01889,P06280,O15270,O14936,P07858 7 +Orthostatic hypotension 0.5640059359513571 1.6102162929035204 0.1073506457146944 1.0 0.688651771655254 14 P07602,P04062 2 +Type 1 muscle fiber atrophy 0.7184080824871617 1.6081636843339693 0.107799334470346 1.0 0.688651771655254 6 P61978 1 +Agitation 0.4516015716782113 1.6070201588062292 0.1080499460321684 1.0 0.688651771655254 33 P42858,Q15165,P50995,P48449,P35637,P10644,P07737,P42892,P04062,Q13501,Q92804 11 +Abnormality of the parathyroid morphology 0.717509491217897 1.604233235486741 0.1086626513666528 1.0 0.6888081149219473 6 P48735 1 +Obsessive compulsive trait 0.7805259124919686 1.601397811908401 0.109288837075621 1.0 0.6901962078762962 5 O75503 1 +Motor neuron atrophy 0.4851781668464031 1.6009124250096465 0.1093963172179877 1.0 0.6901962078762962 23 Q92734,Q16637,Q15165,P50995,P35637,P07737,P31483,Q13501,P22626,Q92804 10 +Respiratory failure 0.4014079630797306 1.5983766564932087 0.1099591765648724 1.0 0.6901962078762962 58 Q92734,Q16637,Q96B26,Q70HW3,Q8TD16,P35637,P07737,P61916,Q9BQP7,P10253,Q92804,P50995,Q9Y619,Q8N183,Q13501,P07602,Q15165,O75306,P23786 19 +Hypokinesia 0.6245242991587107 1.598304773061155 0.1099751656759866 1.0 0.6901962078762962 10 O95831,P04062,P42858,Q99567 4 +Abnormal temper tantrums 0.6454590007031559 1.5979842591839375 0.1100464802906655 1.0 0.6901962078762962 9 Q9BVA1,P04062 2 +Upper limb asymmetry 0.9128113879003552 1.5979531474052062 0.1100534046334575 1.0 0.6901962078762962 2 Q15555 1 +Intestinal polyp 0.5494218451388612 1.597585342238694 0.1101352906907224 1.0 0.6901962078762962 16 P21912,P52701,Q07864,Q15437,P42892,P42345 6 +Ureteral duplication 0.7155372409343244 1.595602483220382 0.1105775727717506 1.0 0.6903693680638955 6 Q9BYW2,O75844,P23786 3 +Abnormal rib cage morphology 0.3994981479228159 1.5955294276286462 0.1105938947730491 1.0 0.6903693680638955 62 P16278,Q32P28,Q14739,O75718,Q9UHX1,Q02750,Q9Y619,O96028,P08236,P54802,Q03164,O75844,Q06124 13 +Abnormality of the hypothalamus pituitary axis 0.397819094341712 1.5902094304944223 0.1117876055028994 1.0 0.6958932845325523 64 O75874,Q07864,Q10713,Q14746,P10644,Q03164,P57740,Q96IJ6,Q9BUK6,P48735,Q9UHX1,O76024,Q8WXW3,Q969G3,P16435,Q96ST3,Q06787,P52701,Q9Y285,P40818,Q99496,Q9UBS4,P42356 23 +Deep plantar creases 0.7761987941562043 1.5837085927832333 0.1132600484880788 1.0 0.7022804362790445 5 Q9Y487,P61978 2 +Abnormal vertebral morphology 0.3546255904293066 1.5836161740413497 0.1132810910084014 1.0 0.7022804362790445 94 O75874,O75718,Q13363,P04066,Q10713,O60216,Q96AY3,O96028,P08236,P10644,P57740,P16278,P48735,Q9UHX1,P10619,Q8WXW3,Q8IWS0,Q9Y619,P61978,P54802,Q14108,P04062,Q9BYW2,Q32P28,Q14739,Q9UJX6,P40818 27 +Restlessness 0.440433066426169 1.5826094240378468 0.1135105141886623 1.0 0.7027361091322816 38 P42858,Q15165,P50995,P48449,P35637,P23378,P10644,P07737,P42892,P04062,Q13501,Q92804 12 +Optic neuropathy 0.5392659693971192 1.5789404567168634 0.1143497152313031 1.0 0.7050262196271998 17 O75306,Q96CU9,O43676 3 +Abnormality of the skull base 0.4275661545713413 1.576831744597225 0.114834245217448 1.0 0.7056751468272064 45 Q14739,Q99567,Q9Y487,Q9UJX6,Q969G3,O43505,P07437,P36543,Q9BYW2,Q9UHX1,P23786,Q9C0B1 12 +Submucous cleft of soft and hard palate 0.5121794804070564 1.5718867934389078 0.1159768078785787 1.0 0.7090028277138692 20 Q15392,Q02750,O43505,Q9Y619,Q08J23,O75844 6 +Intestinal malrotation 0.4584064230132751 1.571240522322317 0.1161267908266956 1.0 0.7090028277138692 26 Q14739,Q15392,O60216,P21964,O96028 5 +Deep palmar crease 0.5973186659247023 1.569201282032224 0.1166010455987787 1.0 0.7100017714406432 11 Q02750,Q9Y487,P61978,P98175 4 +Inflammatory abnormality of the eye 0.4471390764330708 1.568559965378024 0.1167505070938992 1.0 0.7100017714406432 33 Q14739,P02786,P14174,P01889,P18074,Q9NZ08,Q99496,O60216,P49327,P28070,P51648,Q15800,P04439 13 +Hypertrophic cardiomyopathy 0.3546526095332941 1.5666218360850663 0.1172031107287807 1.0 0.7100017714406432 96 Q96CU9,Q9C0B1,P16278,P50402,O43676,P01889,P06280,Q9H061,P10253,P21912,P03886,Q5JTZ9,P54802,Q06124,Q16836,Q02750,O75306,P47985,Q9Y6M9 19 +Astrocytoma 0.6390477935922713 1.5661720720402017 0.117308339005181 1.0 0.7100017714406432 9 Q9BYW2,Q9UJX6,O75874,P48735 4 +Abnormal circulating carbohydrate concentration 0.4438412631917637 1.5600225574685835 0.1187545506244349 1.0 0.7100017714406432 34 Q96CU9,P21912,O43676,Q70HW3,O75306,Q9BWD1,Q5JRX3 7 +Social and occupational deterioration 0.9035587188612116 1.5599149866650643 0.1187799724131895 1.0 0.7100017714406432 2 Q9BQE5 1 +Negativism 0.9035587188612116 1.5599149866650643 0.1187799724131895 1.0 0.7100017714406432 2 Q9BQE5 1 +Flat face 0.5001709756825092 1.5578081157716517 0.1192787415718223 1.0 0.7101575802697536 21 Q03164,Q9Y487,P08236,Q15555 4 +Abnormality of skin pigmentation 0.3634088707440078 1.55200651771338 0.1206606640926539 1.0 0.7148646289446727 114 P21964,Q96AY3,P10644,Q08J23,O75312,Q9H1A4,Q7LGA3,Q15022,O60566,Q96IJ6,P18074,P51648,O75844,P21912,Q15555,P49327,P03886,Q6PGP7,P04062,Q9BYW2,Q96ST3,Q06124,O75648,Q14739,P07602,P52701,P42858,Q9UJX6,P40818,Q02750,Q99496,Q15437,Q06136,Q96PZ0,P07437,P53634,Q96C86,P42345 38 +Abnormal heart valve morphology 0.3907341027863538 1.5442410317045154 0.1225299520559946 1.0 0.7199054179534895 68 P16278,Q06787,P01889,P55795,P06280,Q02750,P21964,P61978,O96028,P08236,Q6PGP7,P04062,P36543,O75844,Q9UHX1,Q06124 16 +Hyperkeratosis 0.4063624844799209 1.5436504617892297 0.1226730332789616 1.0 0.7199054179534895 52 P21912,Q96IJ6,P04066,P06280,O15270,Q02750,Q15437,Q06136,O95721,P04062,O75844,Q07954 12 +Enlarged posterior fossa 0.4330137459312795 1.540877565896335 0.1233465867911645 1.0 0.7217647192165694 40 O60566,Q99567,Q9Y487,Q9UJX6,Q969G3,P49748,Q10713,O43505,Q96GM5,P07437,P36543,Q9BYW2,P23786,Q9C0B1 14 +Abnormality of the posterior pituitary 0.6338591748617481 1.5403695870910108 0.1234702903297038 1.0 0.7217647192165694 9 O76024,Q969G3,Q99496,P42356,Q9UHX1 5 +Abnormal phalangeal joint morphology of the hand 0.4488751899113555 1.534443170258601 0.1249206640227746 1.0 0.7273102452567222 30 O76024,Q15022,Q9BYW2,Q99567,P27635,P18074,Q9UJX6,Q9Y619,O75844,P57740,P46109 11 +Hypoketotic hypoglycemia 0.6667203057596652 1.533826272953473 0.1250723976550916 1.0 0.7273102452567222 7 O43772,Q16836,P31751 3 +Abnormal mitochondria in muscle tissue 0.5310201217365307 1.5263100127850604 0.1269326762142948 1.0 0.7353284983262556 17 O75306,Q96CU9,O43676 3 +Ankle clonus 0.5892388872538621 1.52544499635133 0.1271481428585614 1.0 0.7356311679891354 11 Q8N0X7,P07602 2 +Limitation of joint mobility 0.3645752240155105 1.5228156568749935 0.127804831729527 1.0 0.7375369738860159 85 O75874,O14979,Q8TD16,O60216,Q96AY3,P08236,P16278,Q7LGA3,Q15022,P50402,P18074,P01889,P51648,O75844,P48735,P37268,O76024,P54802,Q9BYW2,Q06124,Q9UJX6,P23786 22 +Wide cranial sutures 0.6631452999766041 1.517224209896565 0.1292100858574898 1.0 0.7380860037512125 7 O75844,P98175 2 +Limb undergrowth 0.4168341232061034 1.5154991259921768 0.1296460514931599 1.0 0.7396389292147741 47 Q14739,P98175,O75874,O75718,Q15392,O60216,O00116,Q03164,P48735,Q9UHX1,P42345 11 +Oligosacchariduria 0.7587925385896895 1.512351870462542 0.1304443719286629 1.0 0.7415235927965598 5 P16278,P10253,P04066 3 +Cerebellar cyst 0.4426853180373912 1.5123113016808716 0.1304546872890162 1.0 0.7415235927965598 32 Q9Y487,Q969G3,O43505,P07437,P36543,P23786 6 +Orthostatic hypotension due to autonomic dysfunction 0.62821600804972 1.51225115424638 0.1304699820474089 1.0 0.7415235927965598 9 P04062 1 +Ventricular hypertrophy 0.4379771808706279 1.5086783400344246 0.1313810033781912 1.0 0.7429538045489436 34 P21912,P06280,O43772,P35573,P10253,P36543,O75844,P13807,P23786 9 +Neoplasm of the adrenal cortex 0.7576224948123051 1.507544476485178 0.1316711524570331 1.0 0.743661508927128 5 P48735 1 +Exostoses 0.8593304843304742 1.5064251306949237 0.1319580734214036 1.0 0.7439066178240845 4 P48735,O75874,Q06124 3 +Neurofibromas 0.6607495404436453 1.5060876966106131 0.1320446625824867 1.0 0.7439066178240845 7 Q07954,Q969G3,P21912 3 +Schizophrenia 0.5200804089426169 1.5044305570057888 0.1324705412715259 1.0 0.744474153755367 18 Q9BQE5,P07602,P04062 3 +Ankyloglossia 0.6603888375524591 1.5044102578845042 0.1324757646576002 1.0 0.744474153755367 7 O75844 1 +Abnormality of dental color 0.8896797153024953 1.5028150005661238 0.132886756613388 1.0 0.7445107026333951 2 P16278 1 +Abnormal midbrain morphology 0.6600149028322667 1.5026710827427028 0.1329238831798247 1.0 0.7445107026333951 7 Q9Y3I1,Q8WXW3,O43924,P04062 4 +Chondrosarcoma 0.9530081879672508 1.501822221511662 0.133143027806194 1.0 0.7445107026333951 3 P48735,Q92804 2 +Progressive psychomotor deterioration 0.6425982665994951 1.4984045207250074 0.1340281825771492 1.0 0.7474993437266066 8 P16278,P07602 2 +Abnormal atrioventricular valve morphology 0.4428868082193585 1.498238505984735 0.1340712945845084 1.0 0.7474993437266066 31 Q06787,P55795,P21964,P04062,O75844,P36543,Q06124 7 +Abnormal diaphysis morphology 0.392673764838755 1.4972613149137055 0.1343252766107627 1.0 0.7474993437266066 56 P16278,Q7LGA3,Q32P28,Q14739,O75718,Q9Y487,Q8N0X7,Q02750,Q13126,Q96AY3,Q9Y619,P08236,O75312,Q06124 14 +Spastic paraparesis 0.5107605421383706 1.4967068714161813 0.1344695475247499 1.0 0.7474993437266066 19 Q8N0X7,P21912,Q6DKK2,P04062 4 +Rimmed vacuoles 0.5447970905532572 1.4959823061655135 0.1346582661085809 1.0 0.7474993437266066 14 P50402,O14979,P31483,Q13501,P22626 5 +Hepatosplenomegaly 0.4404828372985376 1.4934560749748558 0.1353178439982718 1.0 0.7500275028360479 32 P16278,P10619,P15260,Q9Y285,P04062 5 +Abnormal visual fixation 0.6574078389086029 1.4905399265321582 0.1360823264435631 1.0 0.7516192991729184 7 Q5KU26,Q9UN37,P04062,O94992 4 +Osteopenia 0.3890847104280256 1.489375672635468 0.1363884709772649 1.0 0.7516192991729184 64 Q32P28,P07602,O75718,Q9Y487,Q13126,P61978,Q14108,P04062,O75844 9 +Hypohidrosis 0.5825907564491266 1.4893397137461912 0.1363979349457782 1.0 0.7516192991729184 11 Q96IJ6,O14936 2 +Abnormal eating behavior 0.5175275682000336 1.487648762380607 0.1368435465952231 1.0 0.7527902368606179 18 P42858,Q969G3,Q4G0J3,Q96GM5,Q9BYW2,Q6IA86 6 +Ectropion 0.5821253755403548 1.4868089681546752 0.1370652722274861 1.0 0.7527902368606179 11 P61978,P18074,P04062 3 +Elevated pulmonary artery pressure 0.489792498178687 1.4841895767433393 0.1377586342294321 1.0 0.7527902368606179 21 O75844,Q14108,P04062 3 +Accelerated skeletal maturation 0.6023621119666713 1.4833573026818967 0.1379795051937624 1.0 0.7527902368606179 10 Q9BYW2,Q9UJX6,P10644,Q03164 4 +Mitral valve calcification 0.8531141217178455 1.4826756371776266 0.1381606105281823 1.0 0.7527902368606179 4 O75844 1 +Cardiac valve calcification 0.8531141217178455 1.4826756371776266 0.1381606105281823 1.0 0.7527902368606179 4 O75844 1 +Progressive gait ataxia 0.6219403711613989 1.480916103204739 0.1386289313444821 1.0 0.7527902368606179 9 O14773 1 +Somatic mutation 0.4324292404073668 1.4809033630737536 0.1386323267349263 1.0 0.7527902368606179 35 P30154,O75874,P11717,Q92733,Q06124,Q92804 6 +Akinesia 0.6014913018186718 1.4788216411774082 0.1391879903012904 1.0 0.7538758719006861 10 P51114 1 +Parathyroid adenoma 0.7503536501924152 1.47765058884634 0.1395013261959556 1.0 0.7538758719006861 5 P48735 1 +Neoplasm of the parathyroid gland 0.7503536501924152 1.47765058884634 0.1395013261959556 1.0 0.7538758719006861 5 P48735 1 +Hypopigmented skin patches 0.4885401732816945 1.4752838901553829 0.1401362356989333 1.0 0.7543619874806922 21 P21912,P07602,P18074,P49327,P21964,Q15437,P42345 7 +Cavernous hemangioma 0.8500842474553046 1.4710926113359388 0.1412660729398336 1.0 0.7554837732536952 4 Q15437,P21912 2 +Slow saccadic eye movements 0.5997927743280507 1.469970893686064 0.1415696371932409 1.0 0.7554837732536952 10 Q8IV08 1 +Abnormal ureter morphology 0.4772691869432595 1.46556509481135 0.1427668063547313 1.0 0.7584269561630506 22 O76024,Q7LGA3,Q9BYW2,Q9UJX6,Q53EZ4,P23786,O75844,O14936 8 +Proportionate short stature 0.4389865286974874 1.4651952793783478 0.1428676471671688 1.0 0.7584269561630506 31 P16278,P10619,P21912,Q15392,Q9Y619 5 +Abnormality of fontanelles 0.4274078160676587 1.4640128636992933 0.143190433624363 1.0 0.7588530546102316 38 Q32P28,P98175,O75718,Q9Y487,Q9Y619,P36543,O75844 7 +Thin ribs 0.5529299213021733 1.463668094570062 0.1432846570830501 1.0 0.7588530546102316 13 Q32P28,O75844 2 +Cardiac conduction abnormality 0.4429928849271073 1.4629727886638848 0.143474824954195 1.0 0.7589683521931421 28 P50402,P21912,P06280,O43772,O75306,P36543,Q07954,P23786,Q06124 9 +Arthralgia 0.4427796950213939 1.4612231376730027 0.1439542152976287 1.0 0.7606115455409295 28 P14174,P01889,Q03252,P18074,Q9NZ08,P06280,P49327,P28070,Q15800 9 +Slender long bone 0.5521203859438047 1.4589821534675402 0.1445700197355333 1.0 0.7611881763411782 13 Q32P28,Q9Y487,P37268,Q9Y619 4 +Mitral stenosis 0.9406086100889544 1.4563543409868436 0.1452946906452576 1.0 0.7622641446026432 3 O75844 1 +Aortic valve calcification 0.9406086100889544 1.4563543409868436 0.1452946906452576 1.0 0.7622641446026432 3 O75844 1 +Aplasia hypoplasia involving bones of the thorax 0.4421177217274809 1.4557892417147291 0.1454508906940921 1.0 0.7622641446026432 28 Q14739,P98175,Q9Y619,Q03164,O75844,Q06124 6 +Abnormal placental size 0.7445329064578343 1.4536789299703534 0.1460353424193221 1.0 0.7644381977745469 5 O75844 1 +Brittle hair 0.5376035058444253 1.452984815459766 0.1462279700308839 1.0 0.7645585393610139 14 O75844,Q9Y487,Q6PGP7 3 +Neoplasm of the tongue 0.6826428470820929 1.4508826255912963 0.1468125467111916 1.0 0.7667255481197457 6 Q969G3,O43924,P49327 3 +Abnormality of femur morphology 0.3876681836901061 1.4477929602027684 0.1476749621841002 1.0 0.7697818803489597 59 P16278,Q7LGA3,Q32P28,Q14739,P15260,P07602,O75718,Q9Y487,P04066,P06280,Q9Y619,Q96AY3,P04062,O75844,Q9UHX1,P46109 16 +Abnormal enchondral ossification 0.4748073437900165 1.4475627797875616 0.1477393668741624 1.0 0.7697818803489597 22 Q14739,Q13363,Q9Y619,O00116,O96028,P08236,P10644,P40855,Q9BYW2 9 +Lissencephaly 0.4119979112416298 1.4452812191573996 0.1483789109613063 1.0 0.7722214222893851 46 Q9Y487,Q15392,Q86XL3,O14936,P42356,O43505,O95721,P36543,Q9BVA1,P57740,P23786 11 +Amyotrophic lateral sclerosis 0.5174623109588082 1.4393955090894028 0.1500384960409428 1.0 0.7729435411357535 17 Q15165,P50995,P35637,P07737,P31483,Q13501,P22626,Q92804 8 +Long eyelashes 0.4321229954833184 1.4384695059854018 0.1503008836650345 1.0 0.7729435411357535 33 Q5KU26,Q969G3,Q99496,O60216,O94992,Q9Y619,Q03164,Q9UHX1 8 +Erlenmeyer flask deformity of the femurs 0.9351648560359236 1.4363829849176548 0.150893392113758 1.0 0.77357715685212 3 P04062 1 +Postural tremor 0.5288803815250496 1.4323552216383435 0.1520421866970924 1.0 0.77357715685212 15 O75306,O14773,Q14108 3 +Paroxysmal involuntary eye movements 0.5229284463862632 1.432222780607153 0.1520800741597019 1.0 0.77357715685212 16 O75306,Q96CU9,O43676 3 +Abnormal venous morphology 0.4626533012688413 1.4322185890213983 0.1520812733657681 1.0 0.77357715685212 23 P98175,Q9Y487,P47985,P04062,P36543 5 +Foam cells 0.8397363538258984 1.431500445873635 0.1522868392835696 1.0 0.77357715685212 4 P16278,O15118 2 +Coloboma 0.4197147942018197 1.4310465374955572 0.1524168779863224 1.0 0.77357715685212 41 P78318,Q8WXW3,Q96IJ6,Q13363,O43924,O43505,P61978,O96028,Q96ST3,Q9UHX1,O14936 11 +Dystrophic toenail 0.6781059563549485 1.430819488129766 0.1524819563064965 1.0 0.77357715685212 6 O75844 1 +Irregular menstruation 0.644403937709077 1.4298889294762351 0.1527488998563537 1.0 0.77357715685212 7 Q9BYW2,Q06787,P10644 3 +Amegakaryocytic thrombocytopenia 0.8708185053380875 1.4251865488084503 0.1541032835480542 1.0 0.7753501390611407 2 Q06124 1 +Reduced factor xiii activity 0.8708185053380875 1.4251865488084503 0.1541032835480542 1.0 0.7753501390611407 2 Q06124 1 +Reduced factor xii activity 0.8708185053380875 1.4251865488084503 0.1541032835480542 1.0 0.7753501390611407 2 Q06124 1 +Abnormal circulating copper concentration 0.7374335910773706 1.4244048422538915 0.1543293133159102 1.0 0.7753501390611407 5 Q9Y487 1 +Multifocal epileptiform discharges 0.4811409466571983 1.422574791669767 0.1548594559271321 1.0 0.7755506747596103 21 Q08J23,O75503,O14936,Q9UBX3,Q96C86 5 +Positional foot deformity 0.3641892266301202 1.420836778404554 0.1553642159148955 1.0 0.7755506747596103 81 Q8TB36,Q9Y3I1,Q15392,Q13363,Q8TD16,O60216,P21964,Q96AY3,O96028,P08236,P36543,Q15022,Q9Y487,P18074,Q53EZ4,Q9UHX1,Q06330,Q9Y619,P61978,Q9BYW2,P98175,Q9UJX6,P40818,P04792,P42356 25 +Periventricular cysts 0.6758423156099862 1.4208009857153094 0.1553746240649789 1.0 0.7755506747596103 6 Q9Y285 1 +Supranuclear gaze palsy 0.490019603499375 1.4184521916256732 0.1560587871907806 1.0 0.7763321786631878 20 O15118,P07602,P04062 3 +Wide anterior fontanel 0.5067751117588907 1.4167873522680268 0.156545108614472 1.0 0.777892838506533 18 Q32P28,O75718,Q9Y487,Q16134,Q08J23,P40855,P42345 7 +Abnormal cranial nerve physiology 0.3848316894094438 1.4158255602802017 0.1568265839696399 1.0 0.7780943947543698 59 P34897,Q92734,P21912,P07602,O75874,P01889,Q969G3,Q9NZ08,P49327,Q9BQP7,P42356,P40855,P48735,Q9UHX1,Q13501,Q06124 16 +Transient ischemic attack 0.6409325308911495 1.4136606125208775 0.1574615753046735 1.0 0.7782813380119697 7 O75844 1 +Hypertriglyceridemia 0.4983040662793782 1.4123677696740935 0.1578417013874553 1.0 0.7787262771828507 19 P50402,P31751,Q9Y285,O95470,P35573,P28070,P22830 7 +Neurofibrillary tangles 0.8338054937266302 1.408788376316927 0.1588977532099886 1.0 0.7787262771828507 4 O15118,Q9Y287 2 +Hyperpigmentation of the skin 0.3648754066494514 1.408649576330379 0.1589388117158665 1.0 0.7787262771828507 80 P10644,Q7LGA3,Q96IJ6,P51648,O75844,P21912,Q15555,Q6PGP7,Q96ST3,Q9BYW2,P04062,Q06124,Q14739,P42858,Q9UJX6,P40818,Q02750,Q15437,Q06136,Q96PZ0,P07437,P42345 22 +Lipodystrophy 0.4243073212191095 1.408513376002413 0.1589791090196186 1.0 0.7787262771828507 35 P50402,P38606,P31751,Q9Y487,P40818,Q03252,P04066,Q14126,P28070,P36543,O75844,Q9UN37,P42166 13 +Keratosis pilaris 0.8661921708185062 1.4061489684255082 0.1596798940195229 1.0 0.7788715176904655 2 Q02750 1 +Hydrocephalus 0.3816635368452788 1.403308578730809 0.1605248411425097 1.0 0.7793301840149653 64 Q15392,Q13363,Q10713,P21964,O96028,P08236,Q08J23,P40855,O75312,P10644,Q9C0B1,P18074,O43505,Q06330,Q8WXW3,Q969G3,P16435,P04062,P30153,Q02750,P23786 21 +Abnormal electroretinogram 0.4357059670800529 1.403076614169232 0.1605939939409442 1.0 0.7793301840149653 28 O14773,O43924,Q15555,P50897 4 +Eeg with spike wave complexes 0.542293468842617 1.4020004954307397 0.160915098751208 1.0 0.7798326344856931 13 Q14108,O75503 2 +Abnormality of subcutaneous fat tissue 0.5288564427200236 1.400562494607266 0.1613449429983702 1.0 0.7802378305725908 14 O75844,Q9Y487 2 +Abnormal delivery 0.4778921332020455 1.399385433849799 0.1616974325140496 1.0 0.7802680174955267 21 O75844,Q9Y487,Q9Y619 3 +Delayed closure of the anterior fontanelle 0.5539529476582499 1.3973088134841316 0.1623207266320627 1.0 0.7813038630795235 12 Q9Y487 1 +Nevus 0.4349278309771104 1.396669857590288 0.1625128724380515 1.0 0.7813038630795235 28 Q15022,P21912,P18074,Q96AY3,Q15437,P10644,Q9UHX1,Q06124 8 +Generalized clonic seizure 0.830353464078818 1.395563277518966 0.1628460473063113 1.0 0.7813038630795235 4 P07602 1 +Abnormal metatarsal morphology 0.4576882203678606 1.3948119789572506 0.1630725456281061 1.0 0.7813038630795235 23 Q15392,O96028,P08236,O43505 4 +Infantile muscular hypotonia 0.3833975883334479 1.394458715542799 0.1631791280682544 1.0 0.7813038630795235 56 P16278,P07602,Q9Y487,Q969G3,O75306,P36543,Q9BVA1,O14936,P17900 9 +Abnormal circulating acetylcarnitine concentration 0.6693234016171319 1.3919205498755771 0.1639464582124339 1.0 0.7813038630795235 6 O43772,Q16836 2 +Adult onset 0.3816081073543957 1.3910311134843152 0.1642159921140744 1.0 0.7813038630795235 62 Q92734,Q16637,Q9Y3I1,O14979,Q9NXN4,P43243,Q9Y6M1,P38435,P31483,P21912,Q8IV08,Q969G3,O15118,P04062,Q06787,P07602,P31751,P04792,Q9UBS4,P42345 20 +Abnormality of earlobe 0.4571453181952665 1.390717602851207 0.1643110775856575 1.0 0.7813038630795235 23 Q7LGA3,P98175,Q15392,Q8IWS0,P21964,P16435,P46109,P10586 8 +Arteriosclerosis 0.5268828915684308 1.3887153980449574 0.1649193100080404 1.0 0.7824119265328822 14 P61916,P16278,P38435,O15118,O75844 5 +Ovarian neoplasm 0.5154412032862844 1.3852023685539725 0.1659905966748476 1.0 0.7833356257926882 16 P48735,O75874 2 +Patchy changes of bone mineral density 0.8275968251817326 1.3849996718280624 0.1660525677119131 1.0 0.7833356257926882 4 Q13126,Q14739 2 +Decreased circulating total igm 0.7277591143677987 1.384453546319587 0.1662196227932082 1.0 0.7833356257926882 5 Q15904,P49327 2 +Toxemia of pregnancy 0.7275049893428074 1.38340329633808 0.1665412403874206 1.0 0.7833356257926882 5 O43772 1 +Oculomotor apraxia 0.4660016472726468 1.3830311665930453 0.1666553096999585 1.0 0.7833356257926882 22 Q8WXW3,O00429,O14773,O43924,Q10713,Q13501,P04062,P46109 8 +Abnormal brainstem mri signal intensity 0.5086061808576811 1.3823976666282338 0.1668496321762278 1.0 0.7833356257926882 17 O75306,Q96CU9,O43676 3 +Abnormality of pulmonary circulation 0.4354493097516455 1.3821842612038455 0.1669151313973982 1.0 0.7833356257926882 25 O75844,Q14108,P04062 3 +Aplasia hypoplasia of the ribs 0.5014146700246858 1.3813631197181533 0.1671673395717148 1.0 0.7833356257926882 18 Q9Y619,Q03164,Q14739,Q06124 4 +Posterior polar cataract 0.8597864768683352 1.379796441863655 0.1676493284861173 1.0 0.7837369322952533 2 Q9Y287 1 +Vacuolated lymphocytes 0.8594306049822145 1.378332726868315 0.168100583294005 1.0 0.7837369322952533 2 P16278 1 +Abnormal astrocyte morphology 0.5142061241172615 1.3774357656514788 0.1683775614943652 1.0 0.7839645347676695 16 O75874,Q9UJX6,O95831,Q9BYW2,P48735,Q13501,P42345 7 +Proximal tubulopathy 0.4926074643845259 1.373675133288027 0.1695425601124409 1.0 0.7854767059788647 19 O75306,Q96CU9,O43676 3 +Diminished movement 0.5002486999209516 1.3736500961914946 0.1695503365065152 1.0 0.7854767059788647 18 P51114,P04062 2 +Hip pain 0.7249793361455786 1.372963134517052 0.1697638076445575 1.0 0.7854767059788647 5 O75844 1 +Dysphagia 0.3584054320824643 1.37038300790838 0.1705673734935802 1.0 0.7868445776208455 130 Q01105,Q92734,O75874,Q9Y3I1,P35637,Q9NXN4,P07737,P43243,Q03164,P61916,Q96IJ6,P01889,Q9BQP7,P48735,Q9UHX1,O76024,P29372,O15344,P21912,Q15067,Q8N0X7,P03886,O15118,Q14108,Q9Y263,P04062,Q8N183,Q13501,Q7L7X3,Q14739,O00429,P07602,P42858,Q06787,Q96D71,O75306,P42356 37 +Abnormal tissue metabolite concentration 0.5363923489667287 1.367701353069091 0.1714055762497048 1.0 0.7882907470994079 13 P07602,P06865,P06280 3 +Asymmetric growth 0.5989001020122297 1.365342893032879 0.1721453035831588 1.0 0.7900803291744367 9 Q15555,P31751 2 +Abnormal waist to hip ratio 0.6631914935306601 1.3647182517919232 0.1723416208188108 1.0 0.7901766887389426 6 Q9Y6M1,P31751 2 +Varicose veins 0.7224686326945362 1.3625810896489443 0.1730145719578342 1.0 0.7913157784119733 5 P04062 1 +Venous insufficiency 0.7224686326945362 1.3625810896489443 0.1730145719578342 1.0 0.7913157784119733 5 P04062 1 +Vertebral compression fracture 0.5174594464528893 1.3622570195669366 0.1731167866683394 1.0 0.7913157784119733 15 Q32P28,O75718,Q96AY3,Q14108,P04062 5 +Calcinosis 0.7221410964687129 1.361226430147375 0.1734421441730029 1.0 0.7919997404130946 5 O75844 1 +Decreased circulating iga level 0.629006374786147 1.357799792819772 0.1745272207057069 1.0 0.7939258938401114 7 Q15904,P42345,P13051 3 +Abnormal arterial physiology 0.452766974084049 1.3576695170888895 0.1745685735068893 1.0 0.7939258938401114 23 O75844,P01889,P06280 3 +Neoplasm of the skeletal system 0.4132522803788322 1.3569001155163467 0.1748129501528288 1.0 0.7941409749561574 40 Q13126,P48735,Q06124,Q92804 4 +Paraparesis 0.4299370992070716 1.3555339260936885 0.1752475071474415 1.0 0.7941409749561574 28 P21912,Q8N0X7,P35637,P04062,Q6DKK2 5 +Abnormality of alkaline phosphatase level 0.4971501880638382 1.3531404820598922 0.1760107550177245 1.0 0.7948432211805776 18 Q14739,Q9UJS0,Q96AY3,P22626,Q13501,Q8N511 6 +Freckling 0.5575485100847459 1.3526072484623783 0.176181135557887 1.0 0.7948432211805776 11 P52701,P18074,Q99496,P10644,Q06124 5 +Multifocal cerebral white matter abnormalities 0.6598155100455099 1.349727916883127 0.1771032740955065 1.0 0.7951929920288695 6 Q9Y619 1 +Shoulder girdle muscle weakness 0.5454049275949412 1.3491149248234084 0.1773000551195411 1.0 0.7951929920288695 12 O14979,P07602 2 +Bone marrow foam cells 0.8523131672597979 1.3490673052875573 0.1773153486259893 1.0 0.7951929920288695 2 O15118 1 +Proximal upper limb amyotrophy 0.6596654311964915 1.3490613083275167 0.1773172746813875 1.0 0.7951929920288695 6 O14979 1 +Abnormality of the musculature of the upper arm 0.6596654311964915 1.3490613083275167 0.1773172746813875 1.0 0.7951929920288695 6 O14979 1 +Acne 0.5318982540892085 1.3415438292331143 0.1797439494407386 1.0 0.8036765675886997 13 Q92542,P01889,P40818,Q9NZ08,P21964 5 +Short chin 0.5932691309113404 1.336986362876868 0.1812270882823767 1.0 0.807903547862188 9 O75844,Q08J23 2 +Shuffling gait 0.5544217476763362 1.335464776039783 0.1817242763588205 1.0 0.8084661485685002 11 O75844 1 +Xerostomia 0.507361966818773 1.3343501049026445 0.182089143921821 1.0 0.8084661485685002 16 Q14739,Q15165,P50995,P35637,P07737,Q13501,Q92804 7 +Abnormal larynx morphology 0.4292610846684521 1.332636181560264 0.1826512255778931 1.0 0.8084661485685002 25 Q14739,P07602,P27635,P21964,P43243,P36543,Q9UHX1 7 +Abnormality of the upper respiratory tract 0.3524113809763148 1.332312830769367 0.1827574126393767 1.0 0.8084661485685002 84 Q13432,P04066,P21964,P35637,P08236,P10644,P07737,P43243,P36543,P16278,P27635,P01889,Q9UHX1,Q92804,O15344,P29372,P50995,Q969G3,P16435,P54802,Q13501,Q14739,Q06787,P07602,P52701,Q15165,P28070,P13051 28 +Abnormal chorioretinal morphology 0.4857855010866605 1.3272523804220886 0.1844252104148531 1.0 0.8084661485685002 19 O14936,O43505,P04439 3 +Glioma 0.5413116085856817 1.3259988238663616 0.1848400869572661 1.0 0.8084661485685002 12 Q9BYW2,Q9UJX6,O75874,P48735 4 +Multifactorial inheritance 0.5909387727261175 1.3252402069202798 0.1850914936916567 1.0 0.8084661485685002 9 P01889,P42892 2 +Angina pectoris 0.9045976617395888 1.3242155106259863 0.1854314809970705 1.0 0.8084661485685002 3 O75844 1 +Retinal thinning 0.845907473309618 1.3227461600574175 0.1859198072562102 1.0 0.8084661485685002 2 P04439 1 +Macular degeneration 0.5284419320424903 1.3214071078449467 0.1863656573258481 1.0 0.8084661485685002 13 P50897,P04062 2 +Eyelid myoclonus 0.5517839097233053 1.3209926300128478 0.186503821631548 1.0 0.8084661485685002 11 P00374,Q7L7X3 2 +Hypercholesterolemia 0.5516165524981096 1.320074144511391 0.1868102642675326 1.0 0.8084661485685002 11 Q15904,Q8N511 2 +Perisylvian polymicrogyria 0.7119548605600231 1.3190702612924297 0.1871456241585958 1.0 0.8084661485685002 5 Q9BVA1,P42356,P42345 3 +Sparse lateral eyebrow 0.7118929931313185 1.3188140767956158 0.187231276991735 1.0 0.8084661485685002 5 P61978 1 +Abnormality of skeletal maturation 0.3495422167905431 1.317833239818236 0.1875594780189928 1.0 0.8084661485685002 85 Q13363,O60216,P48449,O96028,P10644,Q08J23,Q03164,Q15800,P57740,Q15022,P18074,O75179,Q969G3,Q9Y619,Q14108,P04062,Q9BYW2,Q96ST3,Q06124,Q06787,Q9UJX6 21 +Abnormality of hair texture 0.4045618366451997 1.3171464069904455 0.1877895540607213 1.0 0.8084661485685002 43 Q15022,Q96ST3,Q9Y487,P55795,Q02750,P54802,Q08J23,Q6PGP7,P36543,O75844,P42345,Q06124 12 +Oral pharyngeal dysphagia 0.5275732817372621 1.316343821660651 0.1880586688456378 1.0 0.8084661485685002 13 P42858,Q7L7X3 2 +Cataplexy 0.8096604787182092 1.3162260857425383 0.1880981707839719 1.0 0.8084661485685002 4 O15118 1 +Prolonged neonatal jaundice 0.4839049500882286 1.314440698477837 0.1886979420767358 1.0 0.8084661485685002 19 P61916,Q15904,O15118,Q9BYW2,O14936 5 +Abnormality of the palm 0.339653455554957 1.3126559207511834 0.1892989170707473 1.0 0.8084661485685002 100 Q99567,Q13363,Q14126,O60216,O96028,P10644,P40855,P57740,P07858,Q96IJ6,P27635,Q9Y487,O95831,Q53EZ4,O95721,Q9UHX1,P46109,P21912,Q15555,P16435,Q9Y619,P61978,Q9Y263,Q96ST3,Q14739,P98175,Q02750,Q15437,Q06136,P42345 30 +Decreased circulating acth level 0.7098999494080523 1.3105603487885829 0.1900063427930263 1.0 0.8084661485685002 5 Q969G3,P10644 2 +Aplasia hypoplasia of the cerebellar vermis 0.3752442928440827 1.310172446408138 0.1901375046769005 1.0 0.8084661485685002 60 Q8WXW3,P98175,Q96B26,Q99567,Q9Y487,Q9UJX6,Q969G3,O43924,Q8NFH4,O43505,P07437,P36543,Q9BYW2,P42356,P23786,Q9C0B1 16 +Fetal distress 0.4743914890836553 1.3095003703687118 0.1903649123766055 1.0 0.8084661485685002 20 O75306,Q96CU9,O43676 3 +Exaggerated startle response 0.5874461426018522 1.307624498893975 0.1910007031560519 1.0 0.8090708458320996 9 P16278,P06865 2 +Hemiparesis 0.5030129630295581 1.3069344067126407 0.1912349895007086 1.0 0.8090708458320996 16 O00429,P01889,Q969G3,Q9NZ08,P49327,P03886,Q9BVA1,Q06330,P42345 9 +Abnormal choroid morphology 0.4739985116202479 1.306754593602162 0.1912960707791602 1.0 0.8090708458320996 20 O14936,O43505,P04439 3 +Abnormality of the sense of smell 0.4647635633058161 1.3054305843069889 0.1917462696995711 1.0 0.8090708458320996 21 Q969G3,Q06124,Q9BW83,P04062 4 +Multiple prenatal fractures 0.6178060985419405 1.3052054284480408 0.191822906238213 1.0 0.8090708458320996 7 Q32P28,Q14739 2 +Juvenile onset 0.4110713886327674 1.3049767583736376 0.1919007619690513 1.0 0.8090708458320996 37 P16278,O14773,O15118,P54802,Q8NHS3 5 +Abnormal neuron morphology 0.4233340986480062 1.3010013492019306 0.1932579929065789 1.0 0.8125128489085367 28 Q92734,Q16637,Q15165,P50995,P35637,P07737,P31483,Q13501,P22626,Q92804 10 +Long fingers 0.368485113160901 1.2989510262355737 0.1939607366650537 1.0 0.8139488269547461 70 Q13363,P21964,O96028,Q03164,P57740,P27635,P55795,Q14671,Q9UHX1,P46109,Q15555,Q969G3,Q8IWS0,P16435,Q9Y263,P42892,Q96ST3,Q9Y285,Q06136,P07437,P53634,P23786 22 +Cerebellar atrophy 0.3481278634242052 1.296980323550575 0.1946379570574246 1.0 0.8148112621485496 118 Q9BVA1,Q96CU9,O14773,P42858,Q8IV08,Q96BR5,Q5JRX3,Q8N0X7,Q96D71,Q5JTZ9,Q8NHS3,O75503,Q14108,Q6DKK2,P07437,O14936 16 +Impaired proprioception 0.4202333799871614 1.2937244563440966 0.1957606146249944 1.0 0.8154837628125005 30 O14773,Q8IV08,P54802,Q8N0X7 4 +Intestinal pseudo obstruction 0.6003034668168279 1.2934992501608753 0.1958384432417212 1.0 0.8154837628125005 8 P03886,P61978,O60216 3 +Ventriculomegaly 0.3625455415371498 1.2931622753889154 0.1959549401211311 1.0 0.8154837628125005 157 Q01105,Q96CU9,Q99567,Q15392,Q13363,Q8TD16,O60216,O96028,P36543,Q9C0B1,P16278,O00584,Q9Y487,O43505,Q9UHX1,Q969M3,Q969G3,P04062,Q9BYW2,Q96ST3,Q7L7X3,P07602,P42858,Q5KU26,Q9UJX6,Q86XL3,P30153,O94992,O75306,P23786,P07437,Q9BVA1,O14936,P42345 34 +Abnormal corpus striatum morphology 0.5107756254793803 1.2918006421251578 0.1964261929426078 1.0 0.8159017980212081 14 O75306,P42858 2 +Progressive external ophthalmoplegia 0.5996764805779807 1.290446515662088 0.1968956705012314 1.0 0.8159017980212081 8 P03886,Q96RR1,Q9BQP7 3 +Premature birth 0.4093266522875993 1.2890618407496288 0.1973765883442988 1.0 0.8159017980212081 37 O43676,P27635,Q02750,O60216,P40855,P04062,O75844,P57740,P46109 9 +Papilloma 0.5833064482889394 1.2867290873474746 0.1981887309926873 1.0 0.8159017980212081 9 Q15437 1 +Anorexia 0.4427582004545082 1.2819562724915643 0.1998579860468021 1.0 0.818759560694964 23 P15260,P01889,Q9H3L0,Q14108,P04062 5 +Ascending tubular aorta aneurysm 0.7028503143312933 1.281354771908922 0.2000690826201405 1.0 0.818759560694964 5 O75844,P01889 2 +Lipoma 0.702764674093292 1.280999884531769 0.2001937066531729 1.0 0.818759560694964 5 P27635,P21912,Q15437 3 +Capillary hemangioma 0.6431456965853044 1.2755878608459377 0.2021012474957131 1.0 0.8233234993155728 6 P16435,Q7LGA3,Q9UHX1,Q15436 4 +Glomerulopathy 0.5620109673850023 1.271961720265313 0.2033867205183672 1.0 0.8235974387927055 10 P01889,Q9NZ08,P06280,P49327,Q14108 5 +Benign neoplasm of the central nervous system 0.4412977201309043 1.2708917761684886 0.2037671524878357 1.0 0.8240903146595011 23 Q15437,P21912,O43924 3 +Hypopigmentation of the skin 0.4063288799373373 1.2705911716266418 0.203874129320023 1.0 0.8240903146595011 38 P21912,P07602,Q9UJX6,P18074,P49327,P21964,Q15437,Q6PGP7,O75312,Q9BYW2,P53634,Q96C86,P42345 13 +Abnormality of the phalanges of the toes 0.507087913158226 1.2695657713814927 0.2042393483700937 1.0 0.8248268307383624 14 O75844 1 +Abnormal z disc morphology 0.831316725978662 1.2628799848856864 0.206632313978174 1.0 0.8305513671632478 2 P51114 1 +Abnormal sarcomere morphology 0.831316725978662 1.2628799848856864 0.206632313978174 1.0 0.8305513671632478 2 P51114 1 +Weakness of long finger extensor muscles 0.8313167259786486 1.262879984885632 0.2066323139781936 1.0 0.8305513671632478 2 P31483 1 +Angiokeratoma 0.7952279202279061 1.2608689642046338 0.2073560616601586 1.0 0.8309358471178833 4 P16278,P04066,P06280 3 +Emotional lability 0.3797301122591606 1.2607060084540416 0.2074147883790535 1.0 0.8309358471178833 52 Q96CU9,P07602,Q15165,P50995,P40818,Q969G3,Q8N0X7,P35637,O75306,P10644,P07737,Q8N183,Q13501,Q92804 14 +Myoclonic seizure 0.3870356646037525 1.2602042570385446 0.2075956875648406 1.0 0.8309358471178833 49 P16278,P21912,P07602,Q9Y619,Q8NHS3,O75503,P04062,Q7L7X3 8 +Psoriasiform dermatitis 0.8867924528301941 1.258940457750246 0.2080518391581916 1.0 0.8312673539440026 3 Q15800,P01889 2 +Serositis 0.4828925471986485 1.2585649565921866 0.2081875112679623 1.0 0.8312673539440026 18 Q9BW27,P14174,P01889,Q8NFH4,Q9NZ08,P49327,P57740,Q12769 8 +Hyperintensity of cerebral white matter on mri 0.4889100967488847 1.25514494763406 0.2094261462036937 1.0 0.8312673539440026 17 O75503,P21912,P07602,P17900 4 +Abnormality of the intrinsic pathway 0.5396598564720634 1.2543705821191418 0.2097073400120548 1.0 0.8312673539440026 11 Q9Y487,Q06124 2 +Aplasia hypoplasia involving the vertebral column 0.5167709451395591 1.2533057731741697 0.2100944482173439 1.0 0.8316857251951467 13 P16278,Q14739,P04066,P08236,P10644 5 +Restrictive ventilatory defect 0.5582179356101458 1.2519880549708629 0.2105742165891873 1.0 0.831830205287942 10 P16278,Q9Y285 2 +Abnormality of the musculature of the thigh 0.6377620196297331 1.2516090610940798 0.2107123512323392 1.0 0.831830205287942 6 O14979 1 +Ovarian cyst 0.4985863474039433 1.245986702109548 0.2127692772290501 1.0 0.8325930097376104 15 P21912,P31751,P16435,Q15437,P10644,Q9BYW2 6 +Pericarditis 0.7909544159544062 1.2444808609641305 0.2133226390282536 1.0 0.8325930097376104 4 P14174,P01889,Q9NZ08 3 +Abnormal large intestine physiology 0.4872509536033644 1.2444025085731087 0.213351460123119 1.0 0.8325930097376104 17 P21964,Q06787,P07602,P06280 4 +Sacrococcygeal teratoma 0.8263345195729517 1.242473532421256 0.2140619000024086 1.0 0.8325930097376104 2 Q9BYW2 1 +Neoplasm of the middle ear 0.8263345195729517 1.242473532421256 0.2140619000024086 1.0 0.8325930097376104 2 Q9BYW2 1 +Bilateral camptodactyly 0.8263345195729517 1.242473532421256 0.2140619000024086 1.0 0.8325930097376104 2 Q9BYW2 1 +Tall chin 0.8263345195729517 1.242473532421256 0.2140619000024086 1.0 0.8325930097376104 2 Q9BYW2 1 +Enlarged ovaries 0.7902421652421526 1.241749814897342 0.2143288841035113 1.0 0.8325930097376104 4 Q15437,P21912,P10644 3 +Abnormal circulating iga level 0.5560340416167793 1.240482486996051 0.2147969878639206 1.0 0.8325930097376104 10 Q15904,P13051,P49327,P42345 4 +Limited extraocular movements 0.6929328023633257 1.2402468464670384 0.2148841058931485 1.0 0.8325930097376104 5 O75306 1 +Abnormality on pulmonary function testing 0.4800501414521098 1.2396788025151353 0.2150942205879533 1.0 0.8325930097376104 18 P16278,P01889,Q9Y285 3 +Abnormal size of pituitary gland 0.6927325699444474 1.239416725774811 0.2151912104717168 1.0 0.8325930097376104 5 Q969G3,Q99496 2 +Abnormal mitral valve physiology 0.4107035535244852 1.2368190752100847 0.2161542587232467 1.0 0.833134735669366 32 O75844,P01889,O75306,P04062 4 +Thick hair 0.6027015763776337 1.2341189467978866 0.2171585843525258 1.0 0.833134735669366 7 Q9Y487 1 +Thickened ribs 0.8797669663471532 1.2332163445517026 0.2174950589685815 1.0 0.833134735669366 3 P54802 1 +Abnormality of the gingiva 0.3999826624319421 1.232559009025954 0.2177403381865348 1.0 0.833134735669366 40 P16278,Q15392,P08236,Q14108,P04062 5 +Scapular winging 0.4545176708971625 1.2318907185752492 0.2179899089472337 1.0 0.833134735669366 21 Q9Y487,P50402,Q8TD16,Q06124 4 +Focal white matter lesions 0.6333092350432449 1.231767248139639 0.2180360410493165 1.0 0.833134735669366 6 O00584,P42345 2 +Incoordination 0.3656271015572799 1.2290215717668669 0.2190637181908981 1.0 0.8347962082163459 66 Q01105,P21912,O14773,P07602,P42858,P27635,Q15067,Q9UJX6,Q10713,Q9Y619,Q9NXN4,Q6DKK2,O75503,P04062,P31483,Q9BYW2,Q13501 17 +Abnormality of the vasculature of the eye 0.3635304569541908 1.2288773423155144 0.2191177977190896 1.0 0.8347962082163459 69 P16278,P10619,P21912,Q15555,Q14739,P07602,P01889,P06280,P28070,O75306,P06865,P17900,P04439 13 +Joint laxity 0.3646943936464848 1.2254545906255976 0.2204039892562197 1.0 0.8382791388842046 67 Q96A33,Q96AY3,P36543,P16278,Q9Y487,P55795,Q96HY6,Q9BUK6,Q9BZH6,Q9UHX1,Q969G3,Q9Y619,P61978,Q96ST3,Q9BYW2,Q32P28,Q06787,Q9UJX6,Q96GM5,Q16531,Q96C86 21 +Generalized myoclonic seizure 0.4012723715284406 1.22399701254725 0.2209533545134023 1.0 0.8392317257572426 38 P16278,Q01105,P21912,P07602,Q9Y619,P03886,Q96N66,Q8NHS3,P04062,Q9BYW2,Q7L7X3 11 +Rapidly progressive 0.5854252019403018 1.220979153367029 0.2220939129256747 1.0 0.8392317257572426 8 Q8NHS3 1 +Abnormal circulating igg level 0.5225032493153139 1.2195363053837571 0.2226407049027563 1.0 0.8392317257572426 12 P15260,P18074,P49327,P17812,Q15904,P13051 6 +Generalized hirsutism 0.4246291316593733 1.2167586772103576 0.2236960465345734 1.0 0.8392317257572426 24 Q03164,Q06136,Q9BW83,Q15555 4 +Megaloblastic anemia 0.584377549001182 1.2158674150993627 0.2240354326729832 1.0 0.8392317257572426 8 Q9H3L0 1 +Status epilepticus 0.3955045407506278 1.2153075984289086 0.224248794942369 1.0 0.8392317257572426 42 P07602,Q9Y487,Q15392,P42892,Q7L7X3 5 +Abnormality of the metacarpal bones 0.4045678962105078 1.2136520883659108 0.2248806073281146 1.0 0.8392317257572426 34 P16278,Q32P28,O43924,O96028,P08236 5 +Abnormal blood transition element cation concentration 0.5315185867899515 1.2095565548586642 0.2264490974483539 1.0 0.8392317257572426 11 Q9Y487,Q15904 2 +Abnormal metacarpal morphology 0.4122736023669843 1.2094428571903582 0.2264927519658828 1.0 0.8392317257572426 28 P16278,P08236,Q32P28,O43924 4 +Abnormal insulin level 0.4331004928559372 1.2087315623639272 0.2267659917459572 1.0 0.8392317257572426 23 Q15555,Q16836,P31751,O75844,P53985 5 +Dysmetria 0.3820330214888855 1.208632589108136 0.2268040303727334 1.0 0.8392317257572426 49 Q06787,O14773,Q8IV08,Q96BR5,Q8N0X7,P42356,Q96D71,O75503,Q14671,Q6DKK2,Q8N183,Q5JRX3 12 +Poor motor coordination 0.5499785956849523 1.208562328451567 0.2268310365797856 1.0 0.8392317257572426 10 Q06787,O75503,P42858 3 +Cellular immunodeficiency 0.5674455999298131 1.206538415515171 0.2276099561468236 1.0 0.8392317257572426 9 Q15437 1 +Postaxial polydactyly 0.4813053292784439 1.205887327934492 0.2278609373566618 1.0 0.8392317257572426 17 P61978,Q14739,O43924,Q9BW83 4 +Large intestinal polyposis 0.5966694898337561 1.2056934730236268 0.2279357026212711 1.0 0.8392317257572426 7 Q15437 1 +Colorectal polyposis 0.5966694898337561 1.2056934730236268 0.2279357026212711 1.0 0.8392317257572426 7 Q15437 1 +Exaggerated cupid s bow 0.6845126142629944 1.2053367149351808 0.2280733414756448 1.0 0.8392317257572426 5 P61978,P11233 2 +Prominent veins on trunk 0.871554817961287 1.2031792486855242 0.2289069633161431 1.0 0.8392317257572426 3 Q9Y487 1 +Abnormal cutaneous elastic fiber morphology 0.871554817961287 1.2031792486855242 0.2289069633161431 1.0 0.8392317257572426 3 Q9Y487 1 +Abnormal subcutaneous fat tissue distribution 0.8715548179612869 1.2031792486855242 0.2289069633161431 1.0 0.8392317257572426 3 Q9Y487 1 +Abnormal circulating apolipoprotein concentration 0.871554817961287 1.2031792486855242 0.2289069633161431 1.0 0.8392317257572426 3 Q9Y487 1 +Cerebral dysmyelination 0.5959037854633067 1.202084120019789 0.2293309382451811 1.0 0.8392317257572426 7 P07602 1 +Obsessive compulsive behavior 0.3977459351502233 1.2008965934642457 0.2297913158500841 1.0 0.8392317257572426 39 Q06787,P42858,Q5JRX3,P55795,O60216,Q6DKK2,O75503,Q96ST3,P46109 9 +Absent septum pellucidum 0.4128375120072559 1.2007183604161524 0.2298604695320325 1.0 0.8392317257572426 25 Q15392,O43505,O96028,Q08J23,Q96C86 5 +Abnormal gallbladder morphology 0.4101183230164713 1.1990261552744563 0.230517775593634 1.0 0.8392317257572426 29 Q15437,P47985,P07602,P04062 4 +Postural instability 0.4797330412763685 1.195698207803486 0.2318143510047625 1.0 0.8392317257572426 17 O75503 1 +Substantia nigra gliosis 0.8145907473309757 1.1944647717302777 0.2322962130693329 1.0 0.8392317257572426 2 P04062 1 +Abnormal cerebellar vermis morphology 0.359802654303518 1.1935268975006323 0.232663084511512 1.0 0.8392317257572426 70 Q8WXW3,P98175,Q96B26,Q99567,P42858,Q9Y487,Q9UJX6,Q969G3,O43924,Q8NFH4,O43505,Q14671,P07437,P36543,Q9BYW2,P42356,P23786,Q9C0B1 18 +Uveitis 0.5933060478945094 1.1898375325479948 0.2341102545886442 1.0 0.8392317257572426 7 P14174,P01889,P49327 3 +Widely patent fontanelles and sutures 0.7758797799608232 1.1867078773462532 0.2353428667724424 1.0 0.8392317257572426 4 O75844 1 +Hypertensive crisis 0.6799361922632153 1.1863635818470344 0.2354787472188451 1.0 0.8392317257572426 5 P01889 1 +Primary adrenal insufficiency 0.5165523589359832 1.1857922026036427 0.235704371565401 1.0 0.8392317257572426 12 P16435,Q969G3,Q99496,P40855 4 +Emg chronic denervation signs 0.5049908049962969 1.1844492609363195 0.2362352700707606 1.0 0.8392317257572426 13 O43819,P22626,P07602,P04792 4 +Abnormal adipose tissue morphology 0.369991585636462 1.1842849673490434 0.2363002774578508 1.0 0.8392317257572426 53 P50402,P21912,P31751,Q9Y487,P18074,Q03252,P04066,Q14126,P27635,P49327,P40818,P28070,Q15437,Q9BUK6,P36543,O75844,Q9UN37,P42166 18 +Retinal detachment 0.5162410048146358 1.1840262106077113 0.2364026875042051 1.0 0.8392317257572426 12 O43505 1 +Oculomotor nerve palsy 0.679191601540744 1.1832768435572047 0.2366994470217318 1.0 0.8392317257572426 5 Q969G3 1 +Saccadic smooth pursuit 0.7737668209138304 1.178616470237755 0.2385509302403532 1.0 0.8392317257572426 4 Q06787,O14773 2 +Bacterial endocarditis 0.8106761565836451 1.178495083740029 0.238599291130823 1.0 0.8392317257572426 2 P04062 1 +Hepatocellular adenoma 0.8106761565836285 1.1784950837399617 0.2385992911308498 1.0 0.8392317257572426 2 Q9UKG1 1 +Sensory axonal neuropathy 0.5039100742206316 1.178128656943284 0.2387453190722421 1.0 0.8392317257572426 13 P34897,Q8IV08,Q15067,O95831,Q96RR1,P22626 6 +Elevated circulating long chain fatty acid concentration 0.8103202846975069 1.1770442073403156 0.2391778620200007 1.0 0.8392317257572426 2 P23786 1 +Abnormality of the extraocular muscles 0.8099644128113962 1.1755934876179457 0.2397573591661332 1.0 0.8396139504580414 2 Q9BVA1 1 +Lower limb asymmetry 0.6769305170721341 1.1739039468665713 0.240433501390145 1.0 0.8396139504580414 5 Q15555 1 +Papule 0.4700783965095697 1.1733710908785278 0.2406470249837684 1.0 0.8396139504580414 18 P21912,P38435,P01889,Q9NZ08,Q92990,Q15437,O75844,Q07954 8 +Branchial anomaly 0.575620045082873 1.1731195309542757 0.2407478753198735 1.0 0.8396139504580414 8 P61978,P46109,Q9UHX1 3 +Abnormality of the achilles tendon 0.5132043073478503 1.1668002985182555 0.2432910264403496 1.0 0.8430647415249698 12 P50402,Q8TD16,Q08J23 3 +Abnormal upper limb bone morphology 0.3348633677216213 1.165726153010679 0.2437251826748254 1.0 0.8430647415249698 87 Q13363,O60216,Q96AY3,O96028,P08236,P10644,Q08J23,P16278,Q7LGA3,Q15022,O43924,O75844,Q9UHX1,Q06330,P16435,O00116,Q06124,Q32P28,Q14739,P98175,P42858,Q02750,Q96PZ0 23 +Heteronymous hemianopia 0.6749004686052354 1.165489607191024 0.2438208646288886 1.0 0.8430647415249698 5 Q969G3 1 +Angiofibromas 0.7702931563652584 1.1653188747112788 0.2438899417108482 1.0 0.8430647415249698 4 Q15437 1 +Adenoma sebaceum 0.7702931563652584 1.1653188747112788 0.2438899417108482 1.0 0.8430647415249698 4 Q15437 1 +Truncal obesity 0.4749145338452392 1.164465455214952 0.2442354349228592 1.0 0.8435012300362656 17 Q06787,P31751,P40818,Q8IWS0,O60216,Q10713 6 +Abnormal retinal vascular morphology 0.3794147676213462 1.1598378780858694 0.2461148190757136 1.0 0.8486912697584097 48 P16278,P10619,P21912,Q15555,P07602,O75306,P06865,P17900,P04439 9 +Abnormal skin morphology of the palm 0.3427825834731037 1.1580799075371788 0.2468314286455633 1.0 0.8498619166581771 82 Q99567,Q13363,Q14126,O60216,O96028,P40855,P57740,P07858,Q96IJ6,Q9Y487,Q53EZ4,O95721,Q9UHX1,P21912,P61978,Q96ST3,Q14739,P98175,Q02750,Q15437,Q06136,P42345 22 +Abnormal pulmonary valve morphology 0.5214785542613878 1.1542364838513075 0.2484032287440276 1.0 0.8528538326088987 11 P21964,P10644,Q06124 3 +Abnormal corneal epithelium morphology 0.4784539029348793 1.1517578062691451 0.2494206107921361 1.0 0.8545523091851184 16 Q14739,P01889,P18074,Q9NZ08,P51648,O75844 6 +Abnormal umbilicus morphology 0.364244343447777 1.150864002051852 0.2497881893335845 1.0 0.8545523091851184 54 Q15022,Q9BYW2,Q14739,Q15555,Q9Y487,Q9UJX6,P21964,P08236,P07437,O75844,O14936,Q9C0B1,P42345 13 +Branchial cyst 0.8035587188612101 1.149508516890291 0.2503463568792605 1.0 0.8547810836778994 2 Q9UHX1 1 +Prominent sternum 0.8028469750889815 1.1466136084007392 0.2515413496757577 1.0 0.8556202739537011 2 P16278 1 +Metaphyseal cupping 0.8028469750889795 1.1466136084007317 0.2515413496757608 1.0 0.8556202739537011 2 Q14739 1 +Fatigable weakness of bulbar muscles 0.4819871417780594 1.1434738582657384 0.2528419024973325 1.0 0.8585647132054315 15 Q15165,P50995,P35637,P07737,Q13501,Q92804 6 +Aortic valve stenosis 0.5692001966302589 1.141769238751472 0.253549951914007 1.0 0.8585647132054315 8 O75844,P04062 2 +Increased circulating antibody level 0.5084565143614329 1.1398635199894165 0.254343165247751 1.0 0.8589518594104077 12 Q14108,P04062,P28070 3 +Anterior uveitis 0.8541486052026466 1.139663281481994 0.2544266102313943 1.0 0.8589518594104077 3 P01889 1 +Abnormal tongue morphology 0.3596807102530253 1.1382516381480137 0.2550154219173057 1.0 0.8592244115675084 62 P16278,Q7LGA3,P21912,P98175,P01889,P04066,O43924,Q15437,P10253,P61978,O75844,P42356,Q9C0B1 13 +Decreased pulmonary function 0.7631171525760863 1.1378689019532535 0.2551752284679651 1.0 0.8592244115675084 4 P08236 1 +Hip contracture 0.5077923544518712 1.136095170251434 0.2559167361508814 1.0 0.8595263775386779 12 Q9BYW2,Q7LGA3,Q96AY3,Q8TD16 4 +Subcutaneous hemorrhage 0.3990232767495524 1.1356037003529142 0.2561224595150753 1.0 0.8595263775386779 32 Q6UN15,P38435,P40818,Q02750,Q13126,P21964,Q14108,P10644,P04062,Q06124 10 +Sea blue histiocytosis 0.8526165895336508 1.134084681497508 0.2567590285814616 1.0 0.8604315237072232 3 P16278,O15118 2 +Polar cataract 0.8522605909576334 1.1327886756623762 0.2573030081533209 1.0 0.8609240220839032 3 P08670,Q9Y287 2 +Abnormal bone structure 0.3499877920005115 1.131979449587846 0.2576430743006961 1.0 0.8614223559890485 150 O75874,O75718,Q15392,Q13126,O96028,P08236,P57740,P16278,Q9Y487,P06280,O75844,P48735,P21912,Q9Y619,P61978,P54802,Q14108,P04062,Q32P28,Q14739,P07602,Q86XL3,Q15437 23 +Hydrocele testis 0.6650232806020139 1.1245667633779306 0.2607726644587296 1.0 0.8620570262441668 5 Q9BYW2,Q9UBX3 2 +Motor axonal neuropathy 0.4829925474395584 1.1240668820395854 0.2609846536392606 1.0 0.8620570262441668 14 Q96IJ6,O15270 2 +Hamartomatous polyposis 0.8497350715880307 1.1235980013388007 0.2611836043955018 1.0 0.8620570262441668 3 Q15437 1 +Bone cyst 0.8497350715880307 1.1235980013388007 0.2611836043955018 1.0 0.8620570262441668 3 Q15437 1 +Congenital hepatic fibrosis 0.7971530249110332 1.1234808547402677 0.2612333272339522 1.0 0.8620570262441668 2 Q10713 1 +Abnormality of the female genitalia 0.3354831754337372 1.1232573774987125 0.2613282002328729 1.0 0.8620570262441668 116 O75874,Q07864,Q15392,Q13363,Q03252,O60216,P21964,O96028,P10644,P40855,Q08J23,O75312,P57740,Q9H1A4,O75844,P48735,P21912,P49327,P16435,Q9Y619,Q5JTZ9,Q9BYW2,Q9BW83,Q16740,Q06124,Q01844,Q06787,P52701,P31751,P40818,P30153,Q15437,Q16531 33 +Irregular hyperpigmentation 0.3589222358289988 1.122261642769406 0.2617512099223698 1.0 0.8620570262441668 59 O75648,Q7LGA3,Q14739,P21912,Q15555,P42858,P18074,Q02750,Q15437,Q96PZ0,Q06136,P10644,Q6PGP7,Q96ST3,O75844,P07437,P42345,Q06124 18 +Fatigable weakness of swallowing muscles 0.4822870241040005 1.11980507211197 0.2627968373906446 1.0 0.8620570262441668 14 Q15165,P50995,P35637,P07737,Q13501,Q92804 6 +Fetal onset 0.6081361877519029 1.1195300577976557 0.2629140751575569 1.0 0.8620570262441668 6 P27635,Q9Y285 2 +Breech presentation 0.5641423226294376 1.1170678193010437 0.2639653287470853 1.0 0.8621624886821575 8 Q9Y619 1 +Dysdiadochokinesis 0.4818215464982828 1.116993369318261 0.2639971602832278 1.0 0.8621624886821575 14 Q06787,O75503,Q6DKK2 3 +Abnormality of the abdominal wall 0.3275280028466734 1.1167519490085815 0.2641003991933006 1.0 0.8621624886821575 102 P04066,Q10713,P21964,P08236,P36543,Q9C0B1,P16278,Q15022,P27635,Q9Y487,P18074,O75844,Q9UHX1,P46109,Q15555,Q6PGP7,Q96ST3,Q9BYW2,Q06124,Q32P28,Q14739,Q9UJX6,P30153,P07437,O14936,P42345 26 +Posterior pharyngeal cleft 0.795017793594305 1.1148188144100737 0.2649280723061498 1.0 0.8621624886821575 2 O15344 1 +Abnormal lower limb bone morphology 0.3488356744122368 1.1143211439527192 0.2651414392994582 1.0 0.8621624886821575 150 P15260,Q99567,O75718,Q15392,Q13363,P04066,Q10713,O60216,P21964,Q96AY3,O96028,P08236,P10644,Q08J23,Q03164,P16278,Q7LGA3,Q9Y487,P18074,O95831,O43924,P06280,O43505,O75844,Q9UHX1,Q06330,P46109,Q8WXW3,Q8N0X7,Q8IWS0,P16435,Q9Y619,O00116,Q9Y263,P04062,Q32P28,Q14739,P98175,P07602,P42858,Q06787,Q96PZ0,O14936 43 +Adrenal hyperplasia 0.6623587890540875 1.1135339150901271 0.2654791907910212 1.0 0.8621624886821575 5 P40818,P10644 2 +Polyphagia 0.5771034682509395 1.113428430843713 0.2655244700969281 1.0 0.8621624886821575 7 P42858 1 +Abnormality of circulating glucocorticoid level 0.5140095952340948 1.1130656338420333 0.265680241976248 1.0 0.8621624886821575 11 P16435,Q969G3,P10644 3 +Agenesis of corpus callosum 0.3531023721513907 1.112069115210155 0.2661084347124989 1.0 0.8621624886821575 70 Q15392,Q13363,Q10713,O96028,Q7LGA3,Q15022,P18074,O43505,Q9UHX1,O15344,Q969G3,P03886,P61978,P23378,P78318,P30153,Q86XL3,Q9BVA1,P23786 19 +Generalized joint laxity 0.5034582742615912 1.1115045670007548 0.2663512253365134 1.0 0.8621624886821575 12 Q9Y487,P36543 2 +Abnormal morphology of the abdominal musculature 0.5766477425953668 1.1112793439877893 0.2664481276785801 1.0 0.8621624886821575 7 P42345,Q06124 2 +Dysarthria 0.3435942203366356 1.110777881843083 0.2666639692085484 1.0 0.8621624886821575 136 Q96CU9,Q9Y3I1,Q10713,O75477,P35637,Q9NXN4,O75503,Q08J23,P43243,P07737,P61916,Q96BR5,P18074,P51648,Q14671,O76024,Q8IV08,Q8N0X7,Q5JTZ9,O15118,Q14108,P04062,Q8N183,Q13501,Q06124,Q06787,O14773,P07602,Q02750,Q96D71,O75306,Q6DKK2,P42356 33 +Generalized hyperpigmentation 0.4922528667200017 1.1099421657704331 0.2670239489990145 1.0 0.862707482536601 13 Q96IJ6,P51648,Q02750 3 +Emg myopathic abnormalities 0.4107315893116519 1.1081842482804358 0.2677822521352009 1.0 0.8639188334812817 24 P51114,P50402,P22626,P31483 4 +Toe walking 0.4453603931894713 1.1062131267611996 0.268634282508791 1.0 0.8654071601375575 20 P35637,P50402,Q8TD16,P07602 4 +Leukoencephalopathy 0.3388918403270614 1.1061244233593954 0.268672668869566 1.0 0.8654071601375575 82 Q01105,Q96CU9,P07602,O00584,O43676,Q96BR5,Q9Y285,Q5JTZ9,O75306,O96028,O75503,Q9Y6M9,P17900,Q7L7X3 14 +Severe postnatal growth retardation 0.5304842102143392 1.10569880342531 0.2688569081178213 1.0 0.8654071601375575 10 P27635,Q13363,O96028,O60216 4 +Generalized onset motor seizure 0.3697551041207446 1.104213078345782 0.2695007177325799 1.0 0.8663621503714247 50 P16278,P21912,P07602,Q9Y619,Q8NHS3,P04062,O14936,Q7L7X3 8 +Tissue ischemia 0.4653940806001598 1.102748668386533 0.2701363252932969 1.0 0.8673784893948411 17 O75844,P01889 2 +Memory impairment 0.3889299505220674 1.1025980100127533 0.2702017748192493 1.0 0.8673784893948411 37 Q06787,P07602,P52701,P42858,P01889,Q969G3,Q9NZ08,Q99496,P49327,P03886,P31483,Q13501 12 +Aplasia hypoplasia of toe 0.3950452963439236 1.101113132142749 0.2708474222763013 1.0 0.8683480369582967 32 Q7LGA3,P42858,Q13363,Q8IWS0,Q96PZ0,O96028,P10644,Q03164,Q9UHX1,Q06330 10 +Abnormality of the synovia 0.3484589151833283 1.0992256990020437 0.2716696318886897 1.0 0.8683480369582967 74 P16278,O75718,Q9Y487,Q8TD16,Q02750,O60216,O96028,P08236,P36543,O75844,Q9UHX1,Q06124 12 +Fibroadenoma of the breast 0.7903914590747343 1.0960765526035643 0.2730452747625973 1.0 0.8683480369582967 2 P10644 1 +Abnormality of the tongue 0.3409515545605076 1.095185516585051 0.2734353695770175 1.0 0.8683480369582967 80 Q16637,Q96A33,P04066,Q10713,P40855,Q9C0B1,P16278,Q7LGA3,P01889,O95831,O43924,P10253,O75844,P51114,P46109,P21912,Q9NVV4,Q969G3,P49327,P61978,O75648,P98175,Q99496,Q15437,P42356 25 +Broad phalanx of the toes 0.7518035887287635 1.0946619729119276 0.2736647541833292 1.0 0.8683480369582967 4 O14936 1 +Hypoplasia of the odontoid process 0.6021858587713265 1.0930093095850713 0.2743897122888858 1.0 0.8683480369582967 6 P08236 1 +Contractures of the joints of the lower limbs 0.3686314863525858 1.0924761382517427 0.2746238731085273 1.0 0.8683480369582967 50 Q7LGA3,P50402,P21912,Q9BYW2,Q9UJX6,Q86XL3,Q8TD16,Q8IWS0,O75477,P35637,Q96AY3,Q08J23,P36543,P37268,P23786 15 +Prominent superficial blood vessels 0.5102140191348171 1.0921442084339152 0.2747697205924932 1.0 0.8683480369582967 11 O75844,Q9Y487 2 +Parkinsonism with favorable response to dopaminergic medication 0.527886386429812 1.091989052844217 0.2748379129366389 1.0 0.8683480369582967 10 P04062 1 +Focal myoclonic seizure 0.601905845650277 1.0917616081615078 0.2749378979026691 1.0 0.8683480369582967 6 O75503 1 +Blurred vision 0.7506748642833817 1.0903569118841872 0.2755559544131858 1.0 0.8690881623869355 4 O75306,P04439 2 +Limb girdle muscular dystrophy 0.5720790043443431 1.0897368684027056 0.2758290705586623 1.0 0.8690881623869355 7 O14979 1 +Abnormal lung lobation 0.4995765473416597 1.0894833474180083 0.275940794403307 1.0 0.8690881623869355 12 P21964,Q14739 2 +Heparan sulfate excretion in urine 0.750164081598653 1.0884091069353032 0.27641454256525 1.0 0.8696280987722832 4 P54802 1 +Abnormality of the odontoid process 0.5717550369803933 1.0882095193378336 0.2765026232522536 1.0 0.8696280987722832 7 P08236 1 +Round face 0.4683038768134944 1.087568789606653 0.276785515189085 1.0 0.8696280987722832 16 Q32P28,O75718,P40818,P10644,Q03164 5 +Gait ataxia 0.3555272008865963 1.0873457662276278 0.2768840296734471 1.0 0.8696280987722832 61 Q06787,O14773,P07602,P42858,Q6DN90,Q96BR5,P18074,Q13363,P27635,Q8IV08,Q10713,Q9NVV4,P03886,Q9NXN4,O15118,Q14108,O43292,Q13501 18 +Abnormality of the anterior fontanelle 0.3974501410442801 1.086525612169646 0.2772465158190047 1.0 0.87016019971884 28 Q32P28,O75718,Q9Y487,Q9Y619,P36543 5 +Fatigable weakness of respiratory muscles 0.4724154760633356 1.0843517433273906 0.278208871253135 1.0 0.8709861782383939 15 Q15165,P50995,P35637,P07737,Q13501,Q92804 6 +Large placenta 0.8388843835266591 1.0841851989665527 0.2782826928474122 1.0 0.8709861782383939 3 O75844 1 +Depression 0.3210861690337417 1.0829912243859587 0.2788123182430173 1.0 0.8712348996361061 95 P21964,P35637,Q9NXN4,Q96N66,P10644,Q08J23,P07737,P01889,P06280,P46109,Q92804,P50897,P50995,P03886,Q5JTZ9,P04062,Q13501,Q06787,P07602,P42858,Q15165,P40818,Q6DKK2,Q96C86 24 +Abnormal aortic valve morphology 0.3859598981121438 1.0826989252221653 0.2789420812458179 1.0 0.8712348996361061 38 P01889,P06280,P21964,P61978,P04062,O75844,Q9UHX1 7 +Pain 0.3493896254296466 1.0815048556756124 0.2794726019292228 1.0 0.8721641668276671 159 O75874,P14174,Q70HW3,O75477,P21964,P35637,P10644,P07737,P43243,Q15800,P57740,P22626,Q6UN15,P50402,P01889,Q9NZ08,P06280,O75844,P48735,Q92804,Q9BW27,P21912,P50995,Q969G3,O15270,Q14108,P42892,P04062,Q13501,Q06124,Q01844,Q14739,Q06787,P07602,Q15165,P40818,Q8NFH4,P28070,Q9UBS4,P23786,Q12769,Q07954,O14936 43 +Abnormal thoracic spine morphology 0.4068331341733865 1.0777237060946012 0.2811570759034469 1.0 0.872771820355782 24 P18074,O75477,P51648,P08236,P04062,O75844,Q9UHX1 7 +Chylothorax 0.8369778041469303 1.0772734962762582 0.2813580991926478 1.0 0.872771820355782 3 Q06124 1 +Aplasia hypoplasia of the sternum 0.7472396800529583 1.077261843683971 0.2813633034889695 1.0 0.872771820355782 4 Q9Y619 1 +Short middle phalanx of finger 0.8369526521894085 1.0771823447251268 0.2813988111633394 1.0 0.872771820355782 3 Q03164,Q9UHX1 2 +Premature rupture of membranes 0.5986321127030918 1.0771769556469346 0.2814012182688588 1.0 0.872771820355782 6 Q9Y487 1 +Focal motor seizure 0.4491161398939866 1.0768119540832697 0.2815642837358125 1.0 0.872771820355782 19 P21912,O75503,Q7L7X3 3 +Aplasia hypoplasia of the uterus 0.4703816691297426 1.0717951584257095 0.2838120482164903 1.0 0.8773257210642811 15 P57740,P30153,O96028,Q16740 4 +Thoracic kyphosis 0.4737827864431214 1.068451722695115 0.2853167964027228 1.0 0.8801661884921776 14 P18074,P51648,P08236,P04062,Q9UHX1 5 +Abnormal vascular physiology 0.3787419459171819 1.0675765617928017 0.285711560871563 1.0 0.8807811250671235 43 P01889,P06280,Q14108,P04062,O75844 5 +Ectopic calcification 0.37024935903721 1.0663010207576156 0.2862875882395759 1.0 0.8814649860529495 48 Q14739,O00429,O00584,P38435,P18074,P03886,O00116,P08236,P10644,P40855,P04062,O75844,P23786 13 +Abnormal circulating igm level 0.5055096792650057 1.0662192363240464 0.2863245483872905 1.0 0.8814649860529495 11 Q15904,P15260,P49327,P13051 4 +Decreased activity of mitochondrial complex iv 0.4723092440437265 1.0595586176620078 0.2893454484591946 1.0 0.8871292083031226 14 Q70HW3 1 +Wormian bones 0.4634457276405792 1.056863974267484 0.2905736721657725 1.0 0.888513712693476 16 Q32P28,Q9Y487,O75844 3 +Ureteral stenosis 0.6481451727852735 1.0547513417185486 0.2915390638078077 1.0 0.8890166174437005 5 Q9BYW2 1 +Abnormality of adrenal morphology 0.3944113138960714 1.0524048593751945 0.2926138401618365 1.0 0.8896545308637316 25 O75844,P48735,O75874 3 +Platyspondyly 0.3921753525888183 1.0486582087725598 0.2943354550247619 1.0 0.891512026745028 29 P16278,Q32P28,Q14739,O75874,P04066,P08236,P48735 7 +Aplasia of the uterus 0.5911817180862902 1.0440076309810318 0.2964818590839957 1.0 0.8932110554088026 6 P30153,O96028 2 +Muscular dystrophy 0.4112136497405158 1.042577962668 0.2971438001132922 1.0 0.89460728597903 23 O14979,P22626,O43505 3 +Bifid uvula 0.3852347036797643 1.0419404482739252 0.2974392896356375 1.0 0.8948991177488772 34 Q15392,O43505,Q9Y619,P61978,Q6PGP7,Q9C0B1 6 +Pigmentary retinopathy 0.380527601569293 1.0405670200826465 0.2980765442008217 1.0 0.8962181352322238 39 P21912,Q15555,Q96CU9,O75306,Q8NHS3 5 +Multiple lentigines 0.7357576873245892 1.033578493056585 0.3013332580262924 1.0 0.9031241971015626 4 Q02750,Q06124 2 +Small earlobe 0.5888171188485495 1.0334884562634643 0.3013753699668848 1.0 0.9031241971015626 6 P21964,P98175 2 +Abnormal cortical gyration 0.3288807718014745 1.032472114671835 0.3018510042751512 1.0 0.9033917736062992 115 Q01105,Q8N9N2,Q15392,Q03252,Q8TD16,Q10713,Q96N66,Q08J23,P40855,P36543,P57740,Q9C0B1,Q9UBB6,Q15022,Q9Y487,O43505,Q16134,O95721,P37268,Q9UN37,Q9UPT5,Q05639,Q8WXW3,Q969G3,Q9Y263,Q7L7X3,P34897,Q6DN90,Q5KU26,Q9UJX6,Q86XL3,Q96GM5,O94992,P23786,P07437,Q9BVA1,P42356,O14936,Q96C86,P42345 40 +Immunodeficiency 0.3533105529728503 1.030824231241574 0.3026232529780441 1.0 0.9041591789359588 54 O14646,P15260,Q13432,Q96A33,Q07864,P14174,Q03252,Q13363,P21964,O96028,O60566,P02786,P21266,P46109,P21912,P09601,Q6PGP7,P40818,P35573,P17812,Q15437,P13051 22 +Episodic vomiting 0.5459052192214374 1.0280555181763071 0.3039237129851311 1.0 0.9041591789359588 8 Q9Y619,P61978,P03886 3 +Centrally nucleated skeletal muscle fibers 0.5458198338957411 1.0276391784503958 0.3041195876790139 1.0 0.9041591789359588 8 P51114 1 +Abnormal sella turcica morphology 0.6413920011722514 1.026878577628002 0.3044776427929769 1.0 0.9041591789359588 5 P08236 1 +Male infertility 0.6412621360112558 1.0263430123076809 0.3047299296214159 1.0 0.9041591789359588 5 Q06124 1 +Nonketotic hypoglycemia 0.7334142609450002 1.0246812682095852 0.305513604367583 1.0 0.9041633637162272 4 P23786,P31751 2 +Action tremor 0.3713816679480205 1.0246551754882778 0.3055259202854747 1.0 0.9041633637162272 45 O14773,P07602,P35637,O75306,Q14108,Q5JRX3 6 +Nail dysplasia 0.399362083243973 1.0193854951797343 0.3080199895370725 1.0 0.9041633637162272 24 P10321,Q15022,Q13363,Q9Y619,O96028,P42892 6 +Papilledema 0.4329543137177808 1.019326218118396 0.3080481209787948 1.0 0.9041633637162272 20 P42858,Q969G3,Q96PZ0,P47985,P04062 5 +Abnormal social behavior 0.3497242902003395 1.0177903921326197 0.3087775789530609 1.0 0.9041633637162272 59 Q06787,Q96CU9,P07602,O43676,Q5KU26,Q9UJX6,Q15067,P03886,Q8N183,O75306,Q9BYW2,Q9UHX1,Q9Y6M9 13 +Multiple cafe au lait spots 0.4868234642251595 1.0171921538456832 0.3090620278320739 1.0 0.9041633637162272 12 Q02750,Q15437,P21912,P52701 4 +Abnormal ovarian morphology 0.3883292588656885 1.016449875697042 0.3094152051318219 1.0 0.9041633637162272 29 P21912,P31751,Q15437,Q9BYW2,P57740,Q9BW83,Q06124 7 +Abnormal epidermal morphology 0.4569292637229254 1.0157159805367015 0.3097646558603713 1.0 0.9041633637162272 16 O75844,Q06136 2 +Phenotypic variability 0.3185831895925087 1.0151691624501058 0.3100251975853978 1.0 0.9041633637162272 90 P21912,P07602,P50995,Q70HW3,O14979,Q969G3,Q8TD16,Q9H061,P00374,Q9BVA1,P57740,Q92733,P17900 13 +Steroid resistant nephrotic syndrome 0.638188623912936 1.0136730497479955 0.3107387879303704 1.0 0.9041633637162272 5 Q9BW27 1 +Recurrent hand flapping 0.7304378981411919 1.0133909536022778 0.3108734586982429 1.0 0.9041633637162272 4 P55795 1 +Tics 0.6380867642794523 1.0132533299110584 0.3109391732803752 1.0 0.9041633637162272 5 Q9UHX1 1 +Stroke like episode 0.7299802776967196 1.0116560737092453 0.3117025250429446 1.0 0.9041633637162272 4 P03886 1 +Decreased circulating cortisol level 0.5419401650317011 1.008728093291375 0.3131050547505465 1.0 0.9041633637162272 8 P16435,Q969G3 2 +Abnormality of the biliary system 0.3218973687800163 1.0083445163835898 0.3132890989698222 1.0 0.9041633637162272 105 Q9UJS0,Q96A33,P14174,Q13363,P04066,Q10713,P21964,O96028,P10644,P40855,P61916,P21266,Q16134,P09601,O15118,Q14108,Q6PGP7,P04062,Q9BYW2,O75648,Q14739,P07602,P22830,Q9UJX6,Q15437,Q15904,Q5JPH6,P47985,P00374,O14936,Q00059 31 +Abnormal brainstem morphology 0.3411761235402994 1.0081270827339197 0.3133934575315806 1.0 0.9041633637162272 74 Q06787,Q96CU9,O43676,Q5KU26,Q9UJX6,Q969G3,P30153,Q10713,O43505,P03886,Q53EZ4,O94992,Q9Y6M9,O75306,P07437,Q9BVA1,Q8N183,O14936 18 +Sensorimotor neuropathy 0.3879002907517734 1.0073776941930987 0.3137533062816953 1.0 0.9041633637162272 28 Q92734,P07602,Q5KU26,O95831,O15270,O94992,P03886,Q9Y2R0 8 +Central sleep apnea 0.6365125400646052 1.0067681294071538 0.3140462135181037 1.0 0.9041633637162272 5 Q96A33 1 +Abnormality of the inner ear 0.5279606827298183 1.0066335059044176 0.3141109268600628 1.0 0.9041633637162272 9 Q06124 1 +Generalized onset seizure 0.3145485344054383 1.0050244932791463 0.3148850559588851 1.0 0.9041633637162272 93 P16278,Q01105,P21912,P07602,Q9Y619,P61978,Q8NHS3,O75503,Q14108,P04062,P00374,O14936,Q7L7X3 13 +Neoplasm of the adrenal gland 0.4741021672743576 1.0038877831622446 0.3154327057897457 1.0 0.9041633637162272 13 P48735,O75874 2 +Macule 0.3482123611171303 1.001704368727292 0.3164863960851587 1.0 0.9041633637162272 56 P10644,Q9H1A4,Q7LGA3,O60566,P01889,P18074,O75844,P21912,Q6PGP7,Q96ST3,Q06124,O75648,P52701,P42858,Q02750,Q15437,Q96PZ0,Q06136,P42345 19 +Lewy bodies 0.5532398752213908 1.0010127171959418 0.3168206601998375 1.0 0.9041633637162272 7 P04062,P31483 2 +Abnormal meningeal morphology 0.437681685893193 0.9987481485796552 0.3179167098532176 1.0 0.9041633637162272 19 Q10713,P21964,Q15904,Q9UBS4,Q96ST3,Q9UHX1 6 +High narrow palate 0.3876101010147791 0.9986658595870234 0.3179565843985696 1.0 0.9041633637162272 26 P18074,Q02750,Q9Y619,P61978,P23786,Q96ST3,P46109,Q06124 8 +Abnormality of the gallbladder 0.3786273349296019 0.9983347708762846 0.3181170522396392 1.0 0.9041633637162272 35 P07602,Q15437,O96028,P47985,P04062 5 +Hypopituitarism 0.3831267675579436 0.9978407139392552 0.3183566040796073 1.0 0.9041633637162272 32 Q03164,Q9Y285,Q96IJ6 3 +Delusions 0.4491799948996245 0.9977699915278184 0.3183909046986706 1.0 0.9041633637162272 17 Q9BQE5,P07602,P42858,P04062 4 +Abnormal ldl cholesterol concentration 0.5099451004208898 0.9973932925972904 0.3185736457912955 1.0 0.9041633637162272 10 Q15800,P50402,Q8N511 3 +Motor deterioration 0.6334149673710039 0.9940158833765612 0.3202151347684809 1.0 0.9058176775527058 5 O75503 1 +Spinal deformities 0.8133302729044445 0.9919532153379188 0.3212203481073195 1.0 0.9058176775527058 3 Q9BQP7 1 +Heart block 0.4129574724219066 0.9918927339403014 0.3212498539675028 1.0 0.9058176775527058 22 P06280,O43772,P36543,Q07954,P23786,Q06124 6 +Diffuse cerebral atrophy 0.4603749039341981 0.9876264905289684 0.3233356076404388 1.0 0.9058176775527058 14 P16278,Q06787,O00429,P07602,Q10713,O14936 6 +Thin nail 0.7629893238434164 0.9859162362915952 0.3241742187627503 1.0 0.9058176775527058 2 Q15022 1 +Diminished motivation 0.3861209453625854 0.9857537315816174 0.3242539754288298 1.0 0.9058176775527058 25 P42858,P35637,P06865,P04062,P17900 5 +Abnormality of the septum pellucidum 0.380398600708555 0.98570937130541 0.324275749496179 1.0 0.9058176775527058 33 Q9BVA1,Q9UJX6,Q15392,O43505,O96028,Q96N66,Q08J23,Q9BYW2,Q96C86 9 +Cerebellar hypoplasia 0.3203463271047124 0.9854250942777956 0.3244153083598624 1.0 0.9058176775527058 105 Q96B26,Q8TD16,P36543,Q9Y487,O43924,P55795,O43505,Q9BQP7,Q53EZ4,Q8WXW3,Q969G3,Q9BYW2,P98175,Q8NFH4,P00374,P07437,Q9BVA1,P42356,O14936 19 +Abnormality of salivation 0.3726018762735744 0.9850364204349203 0.3246061815661691 1.0 0.9058176775527058 41 Q14739,Q15165,P50995,P01889,P55795,Q8N0X7,P35637,Q9BVA1,P42356,Q92804 10 +Abnormal pupil morphology 0.5072061816168355 0.9829760017809384 0.3256192499429049 1.0 0.9058176775527058 10 Q96IJ6,O96028,Q96ST3 3 +Myoclonic spasms 0.7219730832995458 0.9813472901109618 0.326421509737504 1.0 0.9058176775527058 4 Q969G3,Q10713 2 +Hemifacial spasm 0.7219730832995458 0.9813472901109618 0.326421509737504 1.0 0.9058176775527058 4 Q969G3,Q10713 2 +Fetal akinesia sequence 0.6296467240156927 0.9785189604948696 0.3278177183999127 1.0 0.9058176775527058 5 P04062 1 +Exercise induced muscle cramps 0.6288247083553233 0.97514094785783 0.3294903493487946 1.0 0.9058176775527058 5 P53985 1 +Psychosis 0.3825917013768413 0.9750431445811626 0.3295388590827672 1.0 0.9058176775527058 30 P61916,Q9Y287,P40818,Q8N0X7,P03886,O15118,P10644,Q13501,Q6DKK2,Q5JRX3 10 +Abnormal cellular phenotype 0.342147741296371 0.9739183974881792 0.3300970582009055 1.0 0.9058176775527058 158 Q96CU9,P15260,P14174,Q70HW3,P21964,P35637,O75503,O43676,P21266,Q9BQP7,O75844,Q9UBX3,P21912,Q969G3,O43772,P09601,Q14108,Q6PGP7,P04062,Q14739,O14773,P07602,Q06787,Q16836,P28070,P17812,Q15437,Q15904,O75306,Q9Y6M9,Q9Y2R0 31 +Abnormal femoral neck head morphology 0.3731896873541955 0.9723163493569336 0.3308931926696052 1.0 0.9058176775527058 39 P16278,Q7LGA3,Q14739,P15260,O75718,Q9Y487,P04066,Q9Y619,Q96AY3,O75844 10 +Retinal degeneration 0.3590922481858797 0.971917760368254 0.3310914634442619 1.0 0.9058176775527058 49 Q7LGA3,P50897,O14773,P42858,P68371,Q96PZ0,O75503,P04062,P04439 9 +Preaxial polydactyly 0.4878895670907949 0.9692594795836031 0.3324157410240582 1.0 0.9058176775527058 11 O96028,O43924 2 +Abnormal circulating long chain fatty acid concentration 0.806834962534211 0.9686712436787996 0.3327092445863688 1.0 0.9058176775527058 3 P23786 1 +Dysuria 0.5337098246467393 0.9686587317032024 0.3327154893228856 1.0 0.9058176775527058 8 P01889 1 +Aplasia hypoplasia of the patella 0.7185072525121909 0.9682580594953868 0.3329155051444199 1.0 0.9058176775527058 4 Q9Y619,Q96AY3 2 +Abnormal substantia nigra morphology 0.8066172158515558 0.9678920491804162 0.3330982855581847 1.0 0.9058176775527058 3 P04062 1 +Retinal telangiectasia 0.6270377435654195 0.9678008260061972 0.3331438512131446 1.0 0.9058176775527058 5 O75306 1 +Hemoptysis 0.7181882338861909 0.9670541957381468 0.3335169416164232 1.0 0.9058176775527058 4 P01889,Q9NZ08 2 +Aplasia hypoplasia of the breasts 0.5333672737680866 0.9669927189367123 0.3335476735210934 1.0 0.9058176775527058 8 Q9Y619 1 +Laryngomalacia 0.4676904044586185 0.9665151013019329 0.333786494103911 1.0 0.9058176775527058 13 P21964,P27635,P07602,P36543 4 +Abnormal b cell subset distribution 0.7576512455516036 0.9646578202613708 0.3347162284742775 1.0 0.9058176775527058 2 P17812 1 +Abnormal epiphyseal ossification 0.4663026557980708 0.9584357042301234 0.3378430984127276 1.0 0.9058176775527058 13 Q14739,O00116,P08236,P10644,P40855 5 +Visual fixation instability 0.7158584674758771 0.9582675353667448 0.3379278698233801 1.0 0.9058176775527058 4 Q5KU26,O94992 2 +Abnormalities of placenta or umbilical cord 0.4554205717988144 0.9578332048067936 0.3381468725749441 1.0 0.9058176775527058 14 P16278,O75844 2 +Wide intermamillary distance 0.4163449441866568 0.9576294462195964 0.3382496452898167 1.0 0.9058176775527058 21 P61978,Q15555,P07437,Q06124 4 +Abnormality of the antihelix 0.5022321771503289 0.9568178836662838 0.3386591840454813 1.0 0.9063758565872828 10 P27635,P98175,Q08J23 3 +Upper airway obstruction 0.7150898762415978 0.955370797308831 0.3393902164962763 1.0 0.9072043617299882 4 P16435,O75844 2 +Polyhydramnios 0.3670780966986358 0.9548573345982784 0.3396498483331318 1.0 0.9072043617299882 43 Q14739,Q70HW3,P21964,P04062,O75844 5 +Redundant skin 0.4371532359828149 0.9546120938727656 0.3397738989572265 1.0 0.9072043617299882 18 Q15022,Q9Y487,Q02750,Q53EZ4,P36543 5 +Dilatation of the cerebral artery 0.5014539877033214 0.952728598915682 0.3407275992073879 1.0 0.9087874810680642 10 P10253,Q9UBS4,P10644 3 +Incomplete penetrance 0.3789503020244703 0.9521537653396424 0.3410190050982553 1.0 0.9089134571128544 31 Q06787,P21912,P50995,Q969G3,O14979,Q14671,Q92733 7 +Abnormal vena cava morphology 0.542221973764143 0.9492696522214564 0.3424834842900042 1.0 0.9105568942811588 7 P98175 1 +Barrel shaped chest 0.7132985032661202 0.9486232261557064 0.3428122738149648 1.0 0.9105568942811588 4 Q32P28,Q14739 2 +Arachnodactyly 0.3799841850780515 0.9466719344996146 0.3438059759342373 1.0 0.9109544582807804 29 Q9Y285,Q13363,P55795,Q969G3,P21964,P16435,O96028,Q96ST3,P57740,P46109 10 +Abdominal pain 0.3331247009616347 0.9456117005490798 0.3443466741755752 1.0 0.9112787688354952 77 P14174,Q70HW3,P35637,P10644,P57740,P01889,Q9NZ08,P06280,Q9BW27,P21912,Q14108,P42892,P04062,Q01844,P40818,O14936,Q8NFH4,Q12769,P23786 19 +Aplasia hypoplasia of the 5th finger 0.464039721543823 0.945269283348194 0.3445214160119794 1.0 0.9112787688354952 13 Q9UHX1,Q969G3,Q96GM5 3 +Decreased ldl cholesterol concentration 0.8000647872837368 0.9444863261688818 0.3449211861065002 1.0 0.9112787688354952 3 Q15800 1 +Abnormal atrioventricular valve physiology 0.3671411068687338 0.943780239690992 0.3452819604000059 1.0 0.9112787688354952 42 P01889,P06280,O75306,P04062,O75844,P36543 6 +Recurrent fractures 0.3787129549213021 0.9422808092210716 0.3460488907433561 1.0 0.9126052373202492 30 Q32P28,O75874,O75718,Q13126,Q96AY3,P48735,Q13501 7 +Hyperinsulinemic hypoglycemia 0.5676553833575618 0.939605082138106 0.3474201684664344 1.0 0.9135148933800552 6 P53985,Q16836 2 +Diplopia 0.4288284697806386 0.9384635411906194 0.3480062449263106 1.0 0.9135148933800552 19 O14773,P04062 2 +Mitochondrial respiratory chain defects 0.6194408444635788 0.9366497673311382 0.3489387432461055 1.0 0.9135148933800552 5 P03886,O75306 2 +Abnormal sputum 0.619367178122352 0.936348154351035 0.3490939624238018 1.0 0.9135148933800552 5 P01889,Q9NZ08 2 +Slowly progressive 0.3419638907787023 0.9340059105906476 0.3503008441163708 1.0 0.9136454421165154 55 Q92734,P50402,O00429,O00584,Q16637,O14773,Q96BR5,Q9Y3I1,O95831,O14979,Q8IV08,Q9NVV4,P04792,Q9NXN4,P31483 15 +Focal non motor seizure 0.4808843298165486 0.9308209176385877 0.3519462075315658 1.0 0.9163420171509574 11 Q01105,Q7L7X3 2 +Cerebellar vermis atrophy 0.4803547721904385 0.9279187378443282 0.3534497238379575 1.0 0.9172413616960648 11 Q14671,P42858,P07437 3 +Skin dimple 0.412020722592648 0.926685989635144 0.3540895938656427 1.0 0.9177008623073328 21 Q03164,P61978,O96028 3 +Bilateral sensorineural hearing impairment 0.3955337375198374 0.9238600366596398 0.3555591922701124 1.0 0.9191224172821278 23 P07602,Q15067,P38159,P03886,P35637,Q13501 6 +Abnormal prolactin level 0.6159968708570016 0.9225591217970808 0.3562370068094507 1.0 0.9195648280012568 5 Q969G3,P10644 2 +Aplasia hypoplasia of the cerebellum 0.3219475087265574 0.9218575526864252 0.3566028826157392 1.0 0.9199823651683668 116 Q96B26,Q99567,Q13363,Q8TD16,Q10713,O60216,O96028,P36543,Q9C0B1,P27635,Q9Y487,O43924,P55795,O43505,Q9BQP7,Q53EZ4,Q8WXW3,Q969G3,Q9BYW2,P98175,Q9UJX6,P30153,Q8NFH4,P23786,P00374,P07437,Q9BVA1,P42356,O14936 29 +Ichthyosis 0.3761484238407601 0.9206468139659336 0.3572348525436402 1.0 0.9210855151110904 30 P50402,P18074,Q02750,P48449,P51648,O95721,P40855,P04062,Q15800 9 +Decreased circulating igg level 0.5105747066275633 0.9189278592910904 0.358133306889977 1.0 0.9228741075775452 9 P18074,P49327,P17812,Q15904,P13051 5 +Abnormality of the larynx 0.3605574893044993 0.9179912773549156 0.3586234324789465 1.0 0.923609034390064 45 Q14739,P07602,Q15165,P27635,P50995,P21964,P35637,P16435,P07737,P43243,P36543,Q9UHX1,Q13501,Q92804 14 +Generalized abnormality of skin 0.3450339367629794 0.9163847583053166 0.3594651266546984 1.0 0.9238709620442492 189 Q99829,P04066,O60216,Q13126,P21964,P10644,P40855,P36543,Q08J23,Q9C0B1,P07858,Q6UN15,P16278,P61916,P38435,Q9Y487,P18074,P01889,P06280,Q92990,Q16134,P51648,O75844,P37268,Q06330,P10619,P21912,O15270,O43772,Q4G0J3,P03886,O15118,Q14108,Q6PGP7,P04062,Q9BYW2,Q06124,Q14739,P98175,Q9UJX6,P40818,Q02750,Q15437,Q06136,O75306,Q15904,P00374,Q07954,O14936,Q00059 50 +Centrocecal scotoma 0.791549747127577 0.914198596991261 0.3606125012463539 1.0 0.9238709620442492 3 O75306 1 +Abnormal metabolic brain imaging by mrs 0.444466166982334 0.912301645230134 0.361609948502374 1.0 0.9238709620442492 15 O43819,P21912,O00429,P07602,Q14353,P03886,O75306 7 +Pleuritis 0.7906728373086529 0.9110882412197396 0.3622488815824254 1.0 0.9238709620442492 3 P01889,Q9NZ08 2 +Neuroinflammation 0.7906728373086529 0.9110882412197396 0.3622488815824254 1.0 0.9238709620442492 3 P01889,Q9NZ08 2 +Pulmonary embolism 0.7906728373086529 0.9110882412197396 0.3622488815824254 1.0 0.9238709620442492 3 P01889,Q9NZ08 2 +Orchitis 0.7906728373086529 0.9110882412197396 0.3622488815824254 1.0 0.9238709620442492 3 P01889,Q9NZ08 2 +Abnormal internal genitalia 0.3164070188965515 0.9107464673266148 0.3624289744809328 1.0 0.9238709620442492 107 O75874,Q07864,Q13363,Q03252,O60216,P21964,O96028,P10644,O75312,P57740,Q9H1A4,O60566,P18074,O75844,P48735,P21912,Q8IWS0,P49327,P16435,Q5JTZ9,Q9BYW2,Q9BW83,Q16740,Q06124,Q01844,Q06787,P52701,P31751,P40818,P30153,Q15437,Q16531,P13051 33 +Lower limb spasticity 0.3370912562817417 0.9099264630621978 0.3628612927034988 1.0 0.9238709620442492 69 P21912,Q96CU9,P07602,Q8N0X7,P35637,O75306,Q6DKK2,P04062 8 +Abnormal heart sound 0.701840455219692 0.9056034702841658 0.3651457713344963 1.0 0.9259837292661672 4 P10253 1 +Accessory spleen 0.5598908340402434 0.9053155920177008 0.3652982184679931 1.0 0.9259837292661672 6 Q15904,Q13363,O96028 3 +Skin plaque 0.6112159984038116 0.9030345711488792 0.3665075471664132 1.0 0.9280053455500136 5 Q06136 1 +Biparietal narrowing 0.507008283788394 0.9009946096310312 0.3675911857075553 1.0 0.9295915216625832 9 Q8WXW3,Q02750,O43924 3 +Ureteropelvic junction obstruction 0.7874898174123057 0.8998126877269131 0.3682199411616484 1.0 0.9295915216625832 3 Q9BYW2 1 +Sporadic 0.4003093817624162 0.8989149471982363 0.3686979657091789 1.0 0.9295915216625832 22 P21912,Q02750,O96028,Q9BWD1,Q96ST3,P04062,P42345 7 +Thyroiditis 0.5584020823176923 0.8987533862370136 0.3687840338878851 1.0 0.9295915216625832 6 Q15437,P49327 2 +Delayed puberty 0.3455662959050602 0.8954924100234486 0.3705239213188216 1.0 0.9318924739865676 52 Q14108,P04062,Q15800,O75844,Q06124 5 +Abnormal oral mucosa morphology 0.3475185592209562 0.8935041675058489 0.3715872413430712 1.0 0.9328702475721828 51 P16278,P01889,Q15392,P08236,Q14108,P04062 6 +Bilateral polymicrogyria 0.4900272787982375 0.8928050003342844 0.3719616081034647 1.0 0.9329053799233809 10 Q01105,Q7L7X3 2 +Hypoplasia of the iris 0.6084590922338199 0.8917959432180883 0.3725023165394465 1.0 0.9337403153264628 5 Q7LGA3,O96028 2 +Decreased activity of the pyruvate dehydrogenase complex 0.4275879273899123 0.8914107383316247 0.3727088589465956 1.0 0.9337403153264628 18 Q96CU9 1 +Acute phase response 0.4068043150787228 0.889438357924782 0.3737675378544438 1.0 0.935282118151892 21 P01889,P21912,P15260,P28070 4 +Dermatological manifestations of systemic disorders 0.3378736321857779 0.889104662963789 0.3739468331284024 1.0 0.935282118151892 63 P61916,Q9BYW2,Q14739,P98175,Q9UJX6,P04066,O43772,Q15904,O15118,Q15437,P10644,P40855,Q6PGP7,O75844,P00374,O14936,Q00059 17 +Abnormality of circulating leptin level 0.6972758884430781 0.8885387151230109 0.3742510401820076 1.0 0.9353627434772914 4 O75844 1 +Osteomyelitis 0.4542195964720391 0.8882725900328424 0.3743941400561423 1.0 0.9353627434772914 13 Q13126,P15260 2 +Young adult onset 0.4638088263743583 0.8872836003742334 0.3749262326595324 1.0 0.9361731471448824 12 Q9Y3I1,O15118,P07602,P31483 4 +Delayed ability to stand 0.7836326270152449 0.8861802520537133 0.3755204033555985 1.0 0.9371375736011532 3 P21912 1 +Abnormal arachnoid mater morphology 0.5165379083240459 0.8853653801467223 0.3759595980597048 1.0 0.9373076582417624 8 Q15904,Q9UHX1,Q9UBS4 3 +Microcornea 0.3820788596703107 0.8848964938248096 0.3762124592321607 1.0 0.9373076582417624 24 Q15555,P18074,O60216,O43505,P07437 5 +Pace of progression 0.3316611391226424 0.8837098883146445 0.3768528410348428 1.0 0.9373125673863094 144 Q92734,Q8TB36,Q16637,Q9Y3I1,O14979,Q10713,O75477,Q13126,Q9NXN4,Q8NHS3,P57740,P50402,O00584,Q96BR5,O95831,Q9BQP7,Q14671,P31483,Q9BW27,Q9NR28,Q8IV08,Q5JTZ9,P54802,Q14108,P04062,Q8N183,Q13501,Q6IA86,O14773,Q02750,P04792,Q96D71,Q9UBS4,Q12769,Q9Y6M9,Q00059 36 +Juvenile myelomonocytic leukemia 0.782612816070603 0.8825818496517823 0.3774622386967277 1.0 0.9373125673863094 3 Q06124 1 +Myeloid leukemia 0.782612816070603 0.8825818496517823 0.3774622386967277 1.0 0.9373125673863094 3 Q06124 1 +Pectus excavatum of inferior sternum 0.782612816070603 0.8825818496517823 0.3774622386967277 1.0 0.9373125673863094 3 Q06124 1 +Abnormal speech prosody 0.515790367977947 0.8817516676060582 0.3779111137426763 1.0 0.9379104568492522 8 P03886,P04062 2 +Increased circulating lactate dehydrogenase concentration 0.4709639349276731 0.8765543715355021 0.3807287318345782 1.0 0.9392241098888258 11 P10253,Q5JRX3 2 +Tapered finger 0.366355510196537 0.874774451718286 0.3816966408895998 1.0 0.940329462651156 34 Q15555,Q06136,Q14671,P42892,Q03164,P23786 6 +Abnormality of visual evoked potentials 0.4248538278354502 0.873400547070627 0.3824447929325114 1.0 0.9403593462885048 18 O75503 1 +Abnormal fear anxiety related behavior 0.3138440029221616 0.8729640451682776 0.3826826756379269 1.0 0.9404311990731388 107 O60216,P21964,P35637,P10644,O75503,P07737,Q03164,Q7LGA3,P55795,P06280,Q92804,P21912,P50995,Q8N0X7,Q4G0J3,P03886,Q9BYW2,Q13501,Q06787,P42858,Q15165,Q9UJX6,P40818,Q96PZ0,Q6DKK2,P17900 26 +Pituitary hypothyroidism 0.5524257554579182 0.8724553452136077 0.382960018885913 1.0 0.9405998937977166 6 Q969G3 1 +Eeg with focal spikes 0.691212441717711 0.8659416103370751 0.3865221828800143 1.0 0.9452577791924018 4 O75503 1 +Abnormality of chromosome segregation 0.602096380325255 0.8659195170738702 0.3865342993236291 1.0 0.9452577791924018 5 Q15437 1 +Fatigue 0.3268183467403149 0.8652223396078919 0.3869167662255752 1.0 0.9454088054377876 77 P21912,P07602,Q15165,P01889,Q9H3L0,Q70HW3,P06280,P35637,P04062,Q92804 10 +Decreased light and dark adapted electroretinogram amplitude 0.7775261285152271 0.8646717298167252 0.3872189901859015 1.0 0.9454088054377876 3 P50897 1 +Aplasia hypoplasia of the optic nerve 0.417944458763115 0.8646601449760586 0.387225350529877 1.0 0.9454088054377876 19 P49454,P30153,P61978,Q9BZH6,O95721,O75312,P37268,Q9UHX1,O14936 9 +Neuronal loss in basal ganglia 0.6905779792673639 0.8635820485081426 0.3878175291043688 1.0 0.9455876525347328 4 O75306 1 +Telecanthus 0.3662403103175239 0.8620734357306713 0.3886471083041192 1.0 0.9455876525347328 33 P21964,Q03164,O75844,Q86XL3 4 +Prenatal maternal abnormality 0.4840965124408933 0.8618124089449359 0.3887907553004164 1.0 0.9455876525347328 10 O43772 1 +Abnormality of the distal phalanges of the toes 0.6899488232704742 0.8612431746386593 0.3891041256483434 1.0 0.9455876525347328 4 O75844 1 +Athetosis 0.4360498032762957 0.8608542328522063 0.3893183311610226 1.0 0.9455876525347328 15 Q96CU9 1 +Abnormal visual field test 0.6896523334012373 0.8601413112233944 0.3897111513335471 1.0 0.9455876525347328 4 Q969G3 1 +Secondary growth hormone deficiency 0.6896523334012373 0.8601413112233944 0.3897111513335471 1.0 0.9455876525347328 4 Q969G3 1 +Apraxia 0.3353143179487158 0.8548425869388756 0.3926382982701688 1.0 0.948475907738414 60 O14646,Q7LGA3,Q8WXW3,O14773,P42858,O43924,Q8N0X7,Q9Y619,P35637,Q5JTZ9,Q96PZ0,Q6DKK2,Q13501,P04062,Q9BVA1,P42356,P46109 17 +Thoracolumbar kyphosis 0.5993193444522172 0.8546543426573495 0.3927425336560146 1.0 0.948475907738414 5 P04062 1 +Abnormality of bone mineral density 0.3184216072760196 0.8545678768257113 0.3927904174874332 1.0 0.948475907738414 118 Q32P28,P16278,Q14739,P07602,O75718,Q9Y487,Q15392,P06280,Q13126,P61978,P54802,Q14108,O96028,P04062,O75844 15 +Abnormal urine carbohydrate level 0.466587194854983 0.8526909235365067 0.3938307255699951 1.0 0.9502114990064068 11 P16278,O00462,P04066,P10253,Q6PGP7 5 +Hypermetric saccades 0.773652464959214 0.8510769468251396 0.3947266104455891 1.0 0.95135445629854 3 O14773 1 +Macular atrophy 0.5208313601599508 0.8493662857633321 0.395677507090113 1.0 0.951527079201694 7 P04062 1 +Muscle fiber atrophy 0.4211659689926003 0.8491539671133164 0.3957956240687705 1.0 0.951527079201694 18 P35637,P61978,P23786,P22626 4 +Abnormal intraocular pressure 0.6857527465285083 0.8456692006445042 0.3977373094323702 1.0 0.951527079201694 4 Q99496,P04439 2 +Narrow nasal ridge 0.5193601693014601 0.8425309150309255 0.3994908426664865 1.0 0.951527079201694 7 O75844 1 +Shyness 0.684658231048904 0.8416141320145741 0.4000039763437044 1.0 0.951527079201694 4 Q9BYW2 1 +Bruxism 0.5447566865257487 0.838825202591024 0.401567405851023 1.0 0.951527079201694 6 P61978,P42858 2 +Hyperextensible skin 0.4551570814023772 0.838772125867169 0.4015971953376773 1.0 0.951527079201694 12 Q9UHX1,Q06124,P04062 3 +Congenital nonbullous ichthyosiform erythroderma 0.6837342868876299 0.838193421019541 0.4019220814014412 1.0 0.951527079201694 4 P04062 1 +Crumpled long bones 0.7252669039146087 0.837533771054654 0.4022926024584936 1.0 0.951527079201694 2 O75718 1 +T cell lymphoma 0.7696689213243169 0.8371383465898532 0.4025148079497613 1.0 0.951527079201694 3 P52701,P49327 2 +Impaired social interactions 0.3547926841403726 0.836670431916532 0.4027778437442353 1.0 0.951527079201694 43 Q06787,Q96CU9,O43676,Q5KU26,Q15067,P03886,Q8N183,O75306,Q9UHX1,Q9Y6M9 10 +Alopecia totalis 0.5440597932519815 0.8357763393531528 0.4032807396340949 1.0 0.951527079201694 6 O75844 1 +Heat intolerance 0.6828731358757351 0.8350071973726224 0.4037136559827328 1.0 0.951527079201694 4 P61978 1 +Abnormal nasal base 0.4785773715110387 0.8330537544118956 0.4048144135256812 1.0 0.951527079201694 10 Q969G3,P21281,Q96GM5,Q93008,Q96ST3 5 +Abnormal circulating gonadotropin concentration 0.4444021927368651 0.8315783571431596 0.4056469825898543 1.0 0.951527079201694 13 P16435,P57740,Q06787,Q969G3 4 +Abnormality of the breast 0.30566812697474 0.8299192234563216 0.4065844553534434 1.0 0.951527079201694 90 O75874,Q96A33,Q13363,O60216,O96028,P10644,P57740,Q7LGA3,P18074,P48735,P10586,P21912,Q15555,Q15067,Q8IWS0,P49327,Q9Y619,P61978,Q06124,Q06787,P52701,P31751,Q99496,Q15437,P07437,P23786 26 +Cortical dysplasia 0.3665058361838947 0.8288935482708931 0.4071646464635345 1.0 0.951527079201694 25 Q9BVA1,O43505,Q96N66,O95721,Q08J23,Q96ST3,P07437,Q96C86 8 +Hypoplastic vertebral bodies 0.6811973655617518 0.8288125502989657 0.4072104854093474 1.0 0.951527079201694 4 P16278,Q14739 2 +High myopia 0.5163240771517984 0.8284423385629474 0.4074200374318986 1.0 0.951527079201694 7 Q9Y487 1 +Hand polydactyly 0.3656964313534698 0.8278049372336662 0.4077809781574375 1.0 0.951527079201694 29 Q8WXW3,Q14739,P98175,Q15067,Q13363,O43924,P21964,O96028,Q9UHX1,Q9BW83 10 +Erythema 0.4123795649263357 0.82710488895451 0.4081776134211543 1.0 0.951527079201694 19 P01889,P18074,P40818,P03886,P51648,Q06136,Q07954,P22830,P07858 9 +Cirrhosis 0.3633166919857754 0.8270714856565168 0.40819654489557 1.0 0.951527079201694 32 Q14739,P11717,P22830,Q10713,Q15904,Q14108,Q6PGP7,P04062,Q06330,Q00059 10 +Meningocele 0.5159901114506219 0.8268941091437972 0.4082970826212695 1.0 0.951527079201694 7 P21964,Q96ST3 2 +Focal segmental glomerulosclerosis 0.3979659821508525 0.8265829572393154 0.4084734804044918 1.0 0.951527079201694 21 Q9BW27,O95470,Q8NFH4,P03886,Q14108,P57740,Q12769 7 +Beaking of vertebral bodies 0.5041021366701692 0.8254203810311294 0.4091329678538908 1.0 0.951527079201694 8 P16278,P08236 2 +Abnormal glial cell morphology 0.3320792622830457 0.8246583274449462 0.4095655968539349 1.0 0.951527079201694 55 Q92734,O75874,P42858,Q9UJX6,Q9Y3I1,O95831,Q10713,P35637,Q9NXN4,O75306,P04062,Q9BYW2,P48735,Q13501,P42345 15 +Abnormal protein glycosylation 0.4330568603848059 0.8241817884771342 0.4098362732311713 1.0 0.951527079201694 14 Q9Y487,Q8N511,P36543 3 +Large for gestational age 0.5037538676436071 0.8237473506115831 0.4100831286388473 1.0 0.951527079201694 8 Q9UKG1,Q12955,P31751 3 +Oromotor apraxia 0.5914130121700782 0.8226867060848021 0.4106861770882823 1.0 0.951527079201694 5 Q9BVA1 1 +Webbed neck 0.3599943234357109 0.8188008034813204 0.4129000724558178 1.0 0.951527079201694 34 Q03164,O75844,Q06124 3 +Pain in head and neck region 0.5896893271855346 0.8157392920580395 0.4146492611469634 1.0 0.951527079201694 5 Q969G3 1 +Hyperhidrosis 0.3640526246815799 0.8141999608636515 0.4155304078932174 1.0 0.951527079201694 29 P21912,P01889,Q02750,P61978,P07858 5 +Telangiectasia of the skin 0.4283753601160803 0.8141753161601655 0.4155445240484217 1.0 0.951527079201694 15 P40818,Q14739,P18074,P06280 4 +Shield chest 0.5885481738590826 0.8111443694870503 0.4172827682277273 1.0 0.951527079201694 5 Q02750,Q06124 2 +Premature loss of primary teeth 0.7181494661921706 0.8100961794260022 0.4178848999453286 1.0 0.951527079201694 2 P53634 1 +Aspiration pneumonia 0.3803860713964637 0.8099820281294712 0.4179505049316061 1.0 0.951527079201694 23 P16278,P78318,Q969G3,O95721,P04062 5 +Aplasia hypoplasia affecting the fundus 0.4026755032103067 0.8087324819171322 0.4186690401896413 1.0 0.951527079201694 20 P49454,P30153,P61978,Q9BZH6,O95721,O75312,P37268,Q9UHX1,O14936 9 +Cerebellar malformation 0.3449032637232858 0.808679207430482 0.4186996911384395 1.0 0.951527079201694 48 Q9Y487,Q969G3,O43505,P07437,P36543,Q9BYW2,P23786 7 +Congenital hypothyroidism 0.587806817793432 0.8081612376462388 0.4189977687590271 1.0 0.951527079201694 5 P10644,Q9Y263,P21281 3 +Increased circulating acth level 0.7612442734292444 0.807807812513827 0.41920122700871 1.0 0.951527079201694 3 P40818 1 +Abnormal uvula morphology 0.3553939283570926 0.8076574932904799 0.4192877797380685 1.0 0.951527079201694 39 Q15392,O43505,Q9Y619,P61978,Q6PGP7,Q9C0B1 6 +Emphysema 0.5115441691037799 0.8063129305960859 0.4200624365901739 1.0 0.951527079201694 7 Q9BYW2,P06280 2 +Eeg with focal epileptiform discharges 0.3630658171052524 0.8060413291621292 0.4202190191702835 1.0 0.951527079201694 29 Q08J23,O75503,P42356,O14936,Q9UBX3,Q96C86 6 +Large hands 0.4578830730365412 0.8054088681683443 0.4205837759312028 1.0 0.951527079201694 11 Q9BYW2,Q9UJX6,P21912 3 +Arteriovenous malformation 0.5370281400632817 0.8050864140112808 0.42076981519397 1.0 0.951527079201694 6 P08236,Q92990 2 +Abnormal brain lactate level by mrs 0.4875025066027318 0.803431517479341 0.4217253642780951 1.0 0.951527079201694 9 O43819,P21912,O00429,P03886,O75306 5 +Abnormal c peptide level 0.6741528760911437 0.8028565654105607 0.4220576433339298 1.0 0.951527079201694 4 Q16836 1 +Abnormal circulating albumin concentration 0.3630600808885132 0.8027639647650522 0.4221111738882102 1.0 0.951527079201694 28 Q9BW27,Q9UJS0,P15260,Q9Y285,O95470,Q8NFH4,Q6PGP7,P57740,Q12769,Q00059 10 +Mitral valve prolapse 0.4014314808047654 0.8001607286080211 0.4236176797139164 1.0 0.9533273589886352 20 Q06787,P55795,Q06124,P36543 4 +Decreased fertility 0.370989307408007 0.7992533900005452 0.4241434995578068 1.0 0.9533273589886352 24 Q9UJX6,P40818,Q02750,Q9BYW2,P57740,Q06124 6 +Open mouth 0.3625482253753029 0.7985815446287854 0.4245330924365649 1.0 0.9533273589886352 28 P30153,Q86XL3,Q10713,P61978,Q96PZ0,P04062,Q96ST3,P42345 8 +Acidemia 0.4560071975838883 0.7952535270811396 0.4264660408163354 1.0 0.9545772671582048 11 P48735 1 +Abnormal sternal ossification 0.6716892476387373 0.7938128747923991 0.4273043763177746 1.0 0.9545772671582048 4 Q9Y619,O96028 2 +Mask like facies 0.4709945229687631 0.7936943849000025 0.4273733699280357 1.0 0.9545772671582048 10 Q05086,Q06787,P38606,P04062 4 +Hypoplastic fifth fingernail 0.5343952479074716 0.7936314597979791 0.4274100122310311 1.0 0.9545772671582048 6 Q969G3 1 +Increased circulating prolactin concentration 0.5083556057693117 0.7915883227354045 0.4286007579498019 1.0 0.9551165833864308 7 Q969G3,Q99496 2 +Dyscalculia 0.4462823146747944 0.7892793906925686 0.4299487293847859 1.0 0.9559836819621264 12 Q06787,P35637,Q9BYW2,Q13501,P22626 5 +Impaired glucose tolerance 0.5327887325016407 0.7866523690361764 0.4314853939162995 1.0 0.9574314907450304 6 Q9UKG1,P40818 2 +Thickened nuchal skin fold 0.4837360182211523 0.7847180846641055 0.432618877121814 1.0 0.9574314907450304 9 P61978,Q13501,Q06124 3 +Ventricular preexcitation 0.581139010710219 0.7814039333745957 0.4345649584356379 1.0 0.9593851328700488 5 P10253,O75306 2 +Aortic regurgitation 0.3765209145827012 0.7811234685986562 0.4347298800508894 1.0 0.9593851328700488 23 P01889,Q9NZ08,Q6PGP7,P36543,O75844,Q9UHX1 6 +Vertebral hypoplasia 0.4946216006271296 0.7800082550784332 0.4353860161649014 1.0 0.9593851328700488 8 P16278,Q14739,P10644 3 +Cloverleaf skull 0.709964412811386 0.7788061780038438 0.4360938979107587 1.0 0.9593851328700488 2 P16435 1 +Cutaneous syndactyly 0.4527385984207369 0.777591191864916 0.4368100553098246 1.0 0.9593851328700488 11 Q9Y619,P98175 2 +Focal t2 hyperintense basal ganglia lesion 0.4100987212123526 0.7767712146318199 0.4372937625752695 1.0 0.9593851328700488 18 Q96CU9 1 +Hyperpituitarism 0.4045519516469804 0.7745439429200082 0.4386091925827873 1.0 0.9598916026393232 19 Q06787,Q969G3,Q99496,P16435,P10644,P57740 6 +Heterogeneous 0.3528784215066634 0.7708948567104685 0.4407692559784033 1.0 0.9600394685817892 36 P61916,O15344,Q8TB36,Q15555,P11717,Q16836,P01889,P04792,P21964,Q9Y619,P03886,O75844,Q9BQE5 13 +Abnormal femoral neck morphology 0.3567154502567169 0.7706494029121332 0.4409147700135807 1.0 0.9600394685817892 32 P16278,O75718,Q9Y487,P04066,Q9Y619,Q96AY3,O75844 7 +Decreased calvarial ossification 0.6650818809473402 0.7696499083946594 0.4415075913423409 1.0 0.9600394685817892 4 O75844 1 +Pontocerebellar atrophy 0.7067615658362998 0.7666437327415646 0.4432933662586376 1.0 0.9600394685817892 2 Q9UN37 1 +Long hallux 0.7067615658362952 0.7666437327415471 0.443293366258648 1.0 0.9600394685817892 2 P10644 1 +Abnormal systemic blood pressure 0.3133525508913878 0.766623313896825 0.4433055098722622 1.0 0.9600394685817892 82 Q10713,P21964,P10644,Q96IJ6,P01889,P06280,Q9NQH7,O75844,Q06330,P21912,O43772,P03886,P42892,P04062,Q9BW83,Q06787,P07602,P40818,Q9UBS4 19 +Myopia 0.3092382042034049 0.7665850439571499 0.4433282705044901 1.0 0.9600394685817892 85 O60216,Q08J23,P36543,P27635,P18074,Q9Y487,P51648,Q9UHX1,P21912,Q15555,Q15067,Q969G3,P61978,Q9BYW2,Q06124,P98175,P42858,Q9UJX6,Q02750,Q15437,O14936 21 +Ectrodactyly 0.4203561765861011 0.7656941842878576 0.4438582883075237 1.0 0.9600394685817892 15 Q8TB36,Q13363,P04792,P48449,O96028 5 +Urticaria 0.4651128342736663 0.7633056726579995 0.4452811198088207 1.0 0.9600394685817892 10 P51648,P18074,P21912 3 +Neoplasm of fatty tissue 0.4910805767108832 0.763122543813898 0.4453903164965278 1.0 0.9600394685817892 8 Q15437 1 +Gastrointestinal hemorrhage 0.3583328035262017 0.7628308606462803 0.4455642738358039 1.0 0.9600394685817892 27 O76024,Q14739,P21912,P52701,P01889,Q9NZ08,P49327,P21964,Q9UHX1,Q06330 10 +Abnormality of the tarsal bones 0.3661014797560138 0.7617490070449394 0.4462098200497835 1.0 0.9600394685817892 24 Q14739,P98175,Q99567,P18074,P16435,O75844,Q9UHX1 7 +Decreased fertility in males 0.4786849884719737 0.7597006053378625 0.447433566840425 1.0 0.9600394685817892 9 Q06124 1 +Vertebral fusion 0.4783458957894702 0.7580245040361304 0.4484363134575355 1.0 0.9600394685817892 9 Q9UHX1,O96028 2 +Facial asymmetry 0.3565900296718997 0.7567793450126082 0.4491820693409747 1.0 0.9600394685817892 30 Q01105,P30153,O96028,Q96ST3,Q03164,Q9UHX1,P46109 7 +Abnormality of krebs cycle metabolism 0.6610189844301219 0.7548618543024693 0.4503318757655037 1.0 0.9600394685817892 4 Q9H3L0 1 +Optic nerve hypoplasia 0.4151898659919102 0.7547848407270684 0.4503780910794792 1.0 0.9600394685817892 16 P61978,O75312,P37268,Q9UHX1,O14936 5 +Oval face 0.5250972469036574 0.7533553582398902 0.4512364012290313 1.0 0.9600394685817892 6 O14936 1 +Polydactyly 0.3479787809089247 0.7532987829640416 0.4512703899888692 1.0 0.9600394685817892 41 Q8WXW3,Q14739,P98175,Q15067,Q13363,O43924,P30153,P21964,P61978,O96028,Q9UHX1,Q9BW83 12 +Abnormal acetabulum morphology 0.4149383852123077 0.7532356206274412 0.4513083377722151 1.0 0.9600394685817892 16 P16278,P08236,O75718 3 +Extramedullary hematopoiesis 0.7449584228145301 0.7517340710930458 0.4522109966908183 1.0 0.9600394685817892 3 Q14739 1 +Protuberant abdomen 0.7448029904911933 0.7512032024505547 0.4525303732041141 1.0 0.9600394685817892 3 P04062 1 +Tonic seizure 0.3646678093453285 0.7507823841913669 0.452783632692376 1.0 0.9600394685817892 24 O14936,P07602,Q7L7X3 3 +Retinal coloboma 0.4626146969091146 0.7504402643585683 0.4529895883783776 1.0 0.9600394685817892 10 Q9UHX1,O14936 2 +Recurrent aspiration pneumonia 0.5231084077786963 0.7447789011344027 0.456405391806276 1.0 0.9600394685817892 6 P04062 1 +Abnormally low pitched voice 0.5714471616710949 0.742766172048936 0.4576232592520644 1.0 0.9600394685817892 5 O60216 1 +Thick cerebral cortex 0.5712499561275378 0.7419833649171941 0.4580974145180789 1.0 0.9600394685817892 5 Q9Y487 1 +Abnormal retinal morphology 0.3342283078132103 0.739000379083881 0.459906767169262 1.0 0.9600394685817892 191 Q96CU9,Q13432,P68371,P21964,Q9UKG1,O96028,Q8NHS3,O75503,P06865,P36543,O75312,P04439,P16278,Q7LGA3,Q9Y287,Q9Y487,P01889,O43924,Q9NZ08,O43505,P51648,Q6P4Q7,Q9UHX1,P10619,P50897,P21912,Q15555,Q15067,Q9Y619,P03886,P04062,Q9BW83,O14773,P07602,P42858,Q16836,Q96PZ0,O75306,P07437,O14936,P17900 41 +Thin skin 0.3551085792670418 0.738736482578287 0.4600670279501577 1.0 0.9600394685817892 25 Q06787,P40818,Q13126,Q9Y619,P10644,O75844 6 +Fragile nails 0.4744062482100507 0.7385846006272039 0.4601592779730019 1.0 0.9600394685817892 9 Q9Y487,Q96ST3 2 +Thick eyebrow 0.342167803538104 0.7382554164569386 0.4603592532958103 1.0 0.9600394685817892 45 O14646,P98175,O95831,P04066,Q969G3,O60216,Q8IWS0,Q96GM5,P08236,Q08J23,Q03164,Q9UHX1 12 +Iris coloboma 0.3542191876356252 0.73710150488696 0.4610606240786812 1.0 0.9600394685817892 30 P78318,Q8WXW3,Q96IJ6,Q13363,O43505,O96028,Q96ST3,Q9UHX1 8 +Abnormal urine cytology 0.3486852074843119 0.7367139715311243 0.461296308582364 1.0 0.9600394685817892 37 P01889,P06280,P09601,Q14108,P04062 5 +Abnormality of the elbow 0.3343360231130672 0.7363149493488063 0.4615390505164147 1.0 0.9600394685817892 50 Q7LGA3,P50402,Q02750,O60216,Q9Y619,Q96AY3,Q03164,P57740,P23786,Q06124 10 +Abnormality of mouth size 0.3064501751341373 0.7321228467455122 0.4640935901820593 1.0 0.9601102719946608 111 Q01105,Q15392,P21964,Q08J23,P16278,Q7LGA3,Q9Y487,P55795,O75844,P46109,Q15555,Q969G3,Q4G0J3,Q9Y619,Q6PGP7,P04062,P42858,Q02750,Q96PZ0,P07437,Q96C86 21 +Esophageal varix 0.739078903710477 0.7317135802901821 0.4643434057537603 1.0 0.9601102719946608 3 P04062 1 +Depletion of mitochondrial dna in muscle tissue 0.65420227920227 0.7301779647185634 0.4652814098761926 1.0 0.9606153524104444 4 P53597,Q9UBX3,Q96RR1 3 +Spina bifida occulta 0.4110432437966373 0.7292904603573027 0.4658240064343548 1.0 0.9608096938598306 16 Q08J23,Q06124 2 +Abnormal aortic valve physiology 0.350743307356631 0.7280798453568292 0.4665647106430388 1.0 0.9608974555913068 33 P16278,P01889,Q9NZ08,Q6PGP7,P04062,P36543,O75844,Q9UHX1 8 +Depressed nasal ridge 0.4068476320892576 0.7270409539224838 0.4672008680664148 1.0 0.9613095061999382 17 P16278,O95721,Q06124 3 +Protrusio acetabuli 0.7376419761084672 0.7268400118148576 0.4673239689558608 1.0 0.9613095061999382 3 O75718 1 +Red eye 0.40229372169413 0.7261465721402085 0.4677489211318097 1.0 0.9617447023453772 18 P34897,Q14739,P02786,P18074,P01889,Q9NZ08,P49327,P28070 8 +Abnormal thyroid stimulating hormone level 0.6953736654804249 0.7237986931433844 0.4691893317801798 1.0 0.9637611930831054 2 P10644 1 +Downslanted palpebral fissures 0.309998574017584 0.7228064026226957 0.469798833193606 1.0 0.9637611930831054 119 O14646,Q15392,P21964,O96028,P36543,Q03164,Q7LGA3,Q9Y487,O95721,O75844,Q15555,Q8N0X7,P61978,Q6PGP7,Q96ST3,Q9BYW2,Q9BW83,Q06124,P78318,P42858,Q9UJX6,P30153,Q02750,Q96PZ0,O14936,P42345 26 +Paresthesia 0.4013748137316544 0.7202133623739247 0.4713936378978998 1.0 0.9661533087793698 18 P01889,P54802 2 +Kyphoscoliosis 0.3387201341224595 0.7173846882832294 0.4731367647631985 1.0 0.9676022304301968 46 Q8TB36,Q5KU26,Q9Y487,Q8N0X7,Q02750,O94992,Q96AY3,P36543,O75844,P57740,Q06124 11 +Arterial thrombosis 0.5650190649324428 0.7173242919358134 0.4731740217147002 1.0 0.9676022304301968 5 P01889,Q9NZ08 2 +Aplasia hypoplasia of the phalanges of the hand 0.3385237083703731 0.7154648476163542 0.474321854554697 1.0 0.9680928418886436 46 Q14739,P38435,Q969G3,Q9UHX1,Q8IWS0,O60216,P10644,P46109,Q03164,O75844,Q06330,P42345 12 +Abnormality of the adrenal glands 0.3220955502807951 0.7150997542344595 0.4745474058081829 1.0 0.9680928418886436 55 P21912,O75874,Q96IJ6,O75844,P48735 5 +Radial deviation of the hand or of fingers of the hand 0.4408295079153977 0.7136379198603149 0.4754511031747035 1.0 0.9687423698048774 11 Q02750,Q06124 2 +Delayed ability to walk 0.3224446005577888 0.7115371324434423 0.4767514490675451 1.0 0.9696199806614276 58 O75648,Q01105,P34897,P21912,P11233,Q6DN90,P27635,Q9NVV4,Q03252,Q10713,Q96GM5,P48449,P35637,P61978,Q96D71,Q96N66,Q96PZ0,O14936 18 +Focal emotional seizure 0.454830508253782 0.7105291303346436 0.4773760732183576 1.0 0.9696199806614276 10 Q7L7X3 1 +Abnormality of the metaphysis 0.3441032115704766 0.7102529178281295 0.4775473107151127 1.0 0.9696199806614276 40 P16278,O75874,Q13126,P48735,Q06124 5 +Abnormal lumbar spine morphology 0.4794578437379176 0.708037513249361 0.4789219620415985 1.0 0.9696199806614276 8 P04062 1 +Abnormality of the thyroid gland 0.2985074721217066 0.7079291010598286 0.478989286863797 1.0 0.9696199806614276 100 O75874,P04066,P21964,P10644,Q9H1A4,O60566,P27635,P50851,O95470,Q9BUK6,P48735,O76024,P21912,Q969G3,P49327,P03886,P61978,Q9Y263,Q6PGP7,P42892,Q9BYW2,Q06787,O00429,P52701,Q9UJX6,Q9Y285,Q99496,Q96GM5,Q15437,Q16531 30 +Facial erythema 0.7318020935360845 0.7071144520607913 0.4794953555713956 1.0 0.9696199806614276 3 P40818 1 +Abnormality of tibia morphology 0.4310546836812043 0.7051828316235313 0.4806964640621096 1.0 0.9696199806614276 12 Q32P28,O95831 2 +Progressive spastic paraplegia 0.3806364680816305 0.7046546782404347 0.481025162311826 1.0 0.9696199806614276 21 Q96CU9 1 +Short nose 0.3001265880987089 0.7044153180637227 0.4811741693137168 1.0 0.9696199806614276 88 Q15392,O60216,P10644,O75312,Q03164,P36543,P38435,Q9Y487,O75844,Q9UHX1,Q969G3,P16435,Q9Y263,P42892,P04062,Q96ST3,Q5KU26,Q02750,Q96GM5,O94992,O14936,Q96C86,P42345 23 +Cogwheel rigidity 0.6470068703091066 0.7043075387123211 0.4812412725471371 1.0 0.9696199806614276 4 P55265,Q96RR1 2 +Weight loss 0.3215840874273551 0.7040313908545355 0.4814132249596461 1.0 0.9696199806614276 64 P21912,P15260,P07602,P01889,P35637,Q06136,P42892,P04062,O75844 9 +Short palm 0.3938190244551687 0.7031010214106178 0.4819927956756773 1.0 0.9696199806614276 19 Q15555,Q9Y619,Q96ST3,Q9UHX1,P46109 5 +Dry skin 0.3503022112118467 0.7012192389880877 0.4831662051281511 1.0 0.9699911298497004 29 P11802,P18074,P04066,Q02750,Q9H4L7,Q99496,P51648,Q06136,Q08J23,Q6PGP7,P37268,P04080,O75352 13 +Supernumerary spleens 0.4778514185419128 0.7004691284646233 0.4836343781398819 1.0 0.970498727638668 8 Q15904,Q13363,O96028,P49454 4 +Hyposmia 0.4061673639920113 0.6994590786239597 0.4842651780473241 1.0 0.9708999810761968 16 Q06124,P04062 2 +Alkalosis 0.5603289053842169 0.6988625848721579 0.4846379118399562 1.0 0.9711897295784498 5 Q9Y619,P01889 2 +Synovitis 0.727919250124024 0.6940738993419076 0.4876358659820803 1.0 0.9746229924528764 3 Q06124 1 +Increased sensitivity to ionizing radiation 0.643184946628547 0.6906482480896078 0.489786619092845 1.0 0.9761950615437436 4 Q969G3,Q99496 2 +Abnormal morphology of the limbic system 0.4644105903629436 0.6895635849859577 0.4904686740574582 1.0 0.9761950615437436 9 Q7L7X3 1 +Abnormal left ventricle morphology 0.3491408572187323 0.6892115749480029 0.4906901337768194 1.0 0.9761950615437436 27 P21912,P06280,P10253,P13807,Q06124 5 +Hereditary nonpolyposis colorectal carcinoma 0.5100919942810032 0.6890290730796208 0.4908049721451348 1.0 0.9761950615437436 6 P63167,O60566,P52701 3 +Distal amyotrophy 0.3312214831325197 0.6872510279325811 0.4919245534072145 1.0 0.9769445290818204 49 Q92734,P21912,Q8TB36,Q96BR5,Q8TD16,Q8N0X7,O15270,P35573,P04792,P35637,P31483,Q13501 12 +Exercise intolerance 0.3488089574633389 0.6871291595941301 0.4920013403648675 1.0 0.9769445290818204 28 Q9Y285,Q9BQP7,P13807,P23786,Q9H2D1,Q9Y2R0 6 +Nephropathy 0.3848753529332577 0.6870537925702717 0.4920488309331556 1.0 0.9769445290818204 20 P06280,Q10713,Q9UKG1,P03886,Q14108,P57740 6 +Fasciculations 0.3433683757061732 0.6864541601660702 0.4924267612891373 1.0 0.977076138578986 36 Q92734,P07602,Q16637,Q8TD16,P06280,P04792,P35637,P07737,P51114,Q13501,P22626 11 +Abnormal autonomic nervous system physiology 0.3479158961992241 0.6850497584316811 0.4933125225067849 1.0 0.977730667958698 30 Q96IJ6,P07602,P42892,P04062 4 +Prominent nasal bridge 0.3339064538376827 0.6836992751313973 0.4941650813021261 1.0 0.9789898995290912 47 P78318,Q96ST3,Q8WXW3,O14936,O43924,Q9BW83,P21964,O95721,Q08J23,P42892,P46109 11 +Joint hypermobility 0.3056552245221304 0.6821321460269238 0.4951553955228251 1.0 0.9805208117844346 83 Q01105,Q7LGA3,O75179,P42858,Q9Y487,Q9Y285,Q8N0X7,Q8IWS0,Q9Y619,Q15904,P21964,Q96PZ0,Q08J23,Q96ST3,Q03164,Q9UHX1,P46109,Q06124 18 +Pancreatic islet cell hyperplasia 0.7229422838509223 0.6774496871291941 0.4981206821212283 1.0 0.984230563051458 3 P53985 1 +Abnormality of globe size 0.3285178208064132 0.6768385858176528 0.498508373383177 1.0 0.9845649600516996 50 Q15555,O43924,O43505,P21964,P07437,O14936 6 +Global brain atrophy 0.3944534069878305 0.6757292019189435 0.49921259194209 1.0 0.9851296382883084 18 P35637,O75306,P07602 3 +Gynecomastia 0.3892137984241903 0.6727150562606992 0.5011285870523099 1.0 0.985597200742518 19 Q15437,Q06787,P21912,P31751 4 +Abnormality of the nail 0.2923697217067186 0.6725502475271464 0.5012334628651658 1.0 0.985597200742518 94 Q13363,P04066,O96028,P10644,Q08J23,Q9C0B1,Q15022,Q9Y487,P18074,O75844,P46109,P10321,Q969G3,Q9Y619,P42892,Q96ST3,Q9BYW2,Q14739,Q9UJX6,O14936,Q02750,Q06136,P23786 23 +Cutis marmorata 0.398104613238611 0.6723212283784208 0.5013792181893701 1.0 0.985597200742518 17 Q08J23,Q4G0J3,O60216,Q9C0B1 4 +Abnormality of female external genitalia 0.3463400504120295 0.6721032704235823 0.5015179546502502 1.0 0.985597200742518 30 Q15392,O60216,Q9Y619,P10644,Q08J23,P40855 6 +Hypoplasia of the pons 0.4015986201093355 0.6716652496854639 0.5017968288184567 1.0 0.985597200742518 16 Q9BVA1,Q9UJX6,O14936 3 +Encephalocele 0.432659860583912 0.6701909338036661 0.5027360825878502 1.0 0.9868604199579448 11 Q8WXW3,Q10713,O43505 3 +Macroglossia 0.3447018792310807 0.6689632065517894 0.5035189488368079 1.0 0.9871073955665476 32 P16278,P21912,P04066,Q15437,P10253,P61978,Q9C0B1 7 +Abnormal circulating citrulline concentration 0.6364540510594573 0.666739479207647 0.5049385565809534 1.0 0.98779633358359 4 Q9Y619,P03886 2 +Narrow palpebral fissure 0.403719149882066 0.6663528030655043 0.5051856222741031 1.0 0.98779633358359 15 P27635,Q8IWS0,Q4G0J3,P38159,Q53EZ4,Q03164 6 +Abnormal size of the palpebral fissures 0.3056518558647094 0.6657167529601691 0.5055921632873219 1.0 0.98779633358359 82 P38159,Q08J23,Q03164,Q7LGA3,P55795,Q53EZ4,O75844,Q9UHX1,P46109,Q15555,Q8IWS0,Q4G0J3,Q9Y619,P61978,P98175,P42858,Q5KU26,Q02750,Q96PZ0,P07437 20 +Congestive heart failure 0.3184775285427564 0.6654255825089136 0.5057783267267659 1.0 0.98779633358359 60 P16278,P21912,Q15555,Q70HW3,P06280,P10253,O75306,P07437,P22626 9 +Scleral staphyloma 0.6358637502061877 0.6646519522785523 0.5062731320373568 1.0 0.98779633358359 4 Q9UN37,P36404 2 +Axonal degeneration 0.4797082518557898 0.6609831015853266 0.5086231506450882 1.0 0.988764503504818 7 Q92734,Q6DKK2 2 +Periauricular skin pits 0.4229494802907242 0.6609527649957494 0.5086426060302478 1.0 0.988764503504818 12 Q07954,P61978,O96028 3 +Abnormality of the amniotic fluid 0.3105120086439429 0.6594861133216903 0.5095836605272455 1.0 0.9890792505888826 77 Q14739,Q9Y285,Q70HW3,Q9UHX1,P21964,Q53EZ4,Q6PGP7,P04062,O75844,P51114,P23786 11 +Anisocoria 0.5494230738740351 0.656297284895398 0.5116328641644525 1.0 0.9890792505888826 5 Q96IJ6 1 +Wide nasal ridge 0.6333062630491282 0.6556255524765143 0.5120650804051956 1.0 0.9890792505888826 4 P61978,Q15022 2 +Vasculitis 0.5019199014196634 0.6544057785263606 0.512850412504481 1.0 0.9890792505888826 6 P01889,Q9NZ08 2 +Vertebral wedging 0.6765124555160302 0.654356352782412 0.5128822477103046 1.0 0.9890792505888826 2 Q96AY3 1 +Cyanosis 0.3863940939335191 0.6542013657028702 0.5129820818284028 1.0 0.9890792505888826 19 O75844,O43772 2 +Abnormal morphology of the radius 0.4216923392836247 0.6541311896009335 0.5130272887276159 1.0 0.9890792505888826 12 Q32P28 1 +Hypoventilation 0.4294527643152271 0.6532446895156091 0.5135985438386097 1.0 0.9890792505888826 11 P61978,O75306 2 +Open operculum 0.6754448398576507 0.6504877370916287 0.5153772203603793 1.0 0.9890792505888826 2 P07954 1 +Paralysis 0.3259220017773021 0.650456855397113 0.5153971621027442 1.0 0.9890792505888826 50 P50402,P21912,Q8TB36,Q15165,P50995,P04792,P35637,P10253,P07737,P04062,P42356,Q13501,P17900,Q92804 14 +Recurrent upper and lower respiratory tract infections 0.6750889679715365 0.6491997629034212 0.5162092649427543 1.0 0.9890792505888826 2 P13051 1 +Abnormal thyroid hormone level 0.6750889679715302 0.6491997629033995 0.5162092649427683 1.0 0.9890792505888826 2 O14654 1 +Fatty replacement of skeletal muscle 0.5475351023908895 0.6489838126047458 0.5163488392118092 1.0 0.9890792505888826 5 P51114 1 +Postaxial hand polydactyly 0.4206838385823934 0.6486667843925608 0.5165537781922187 1.0 0.9890792505888826 12 Q9BW83,O43924 2 +Narrow mouth 0.3155500554781757 0.6482968490911961 0.5167929715946531 1.0 0.9890792505888826 68 Q7LGA3,Q15555,P42858,Q9Y487,Q15392,P21964,Q9Y619,Q96PZ0,Q6PGP7,P07437,P04062,O75844,P46109,Q96C86 14 +Cutaneous photosensitivity 0.3853154124531952 0.6471383885150442 0.5175423820750078 1.0 0.9890792505888826 19 P18074,Q06136,Q14108,Q08J23,P37268 5 +Progressive spastic quadriplegia 0.4766226749515913 0.6471352484851509 0.5175444141306991 1.0 0.9890792505888826 7 P07602 1 +Skin pit 0.4118956368009563 0.6470921315635539 0.5175723174629139 1.0 0.9890792505888826 13 Q07954,P61978,O96028 3 +Decreased testicular size 0.3653672458188163 0.6463515830668828 0.5180516886302926 1.0 0.9890792505888826 22 Q06787,P27635,Q8IWS0,O43505,O75312 5 +Thickened helices 0.5467926746680745 0.6461125620003795 0.518206460526031 1.0 0.9890792505888826 5 Q06124 1 +Acanthosis nigricans 0.4418298136617475 0.6445663126060938 0.519208271511435 1.0 0.9897938435513464 10 P28070 1 +Abnormality of neuronal migration 0.309269597595801 0.6415131044736956 0.5211893695792165 1.0 0.99149614018375 129 Q01105,Q8N9N2,Q15392,Q03252,Q8TD16,Q10713,Q96N66,Q08J23,P40855,P36543,P57740,Q9C0B1,Q9UBB6,Q15022,Q9Y487,O43924,O43505,Q16134,O95721,P37268,Q9UN37,Q9UPT5,Q05639,Q8WXW3,Q969G3,P61978,Q9Y263,Q7L7X3,P34897,Q06787,Q6DN90,Q5KU26,Q9UJX6,Q86XL3,Q96GM5,O94992,P23786,P07437,Q9BVA1,P42356,O14936,Q96C86,P42345 43 +Ovoid vertebral bodies 0.4748433583398992 0.6391727205249814 0.5227105764085107 1.0 0.992882079018774 7 P54802 1 +Abnormal cerebral ventricle morphology 0.328871325343385 0.6390998437678427 0.5227579815555299 1.0 0.992882079018774 198 Q01105,Q96CU9,Q99567,Q15392,Q13363,Q8TD16,Q10713,O60216,P21964,O96028,P08236,P10644,Q08J23,P36543,O75312,P57740,Q9C0B1,P16278,O00584,Q9Y487,O43505,Q9UHX1,Q8WXW3,Q969M3,Q969G3,P04062,Q9BYW2,Q96ST3,Q7L7X3,P07602,P42858,Q5KU26,Q9UJX6,Q86XL3,Q02750,P30153,O94992,O75306,P23786,P07437,Q9BVA1,O14936,P42345 43 +Central hypothyroidism 0.4402458075222133 0.6365970656459412 0.5243873370437329 1.0 0.992882079018774 10 P27635,Q969G3 2 +Short ribs 0.4641569710929017 0.6364672755490475 0.5244719037419547 1.0 0.992882079018774 8 Q9Y619 1 +Lambdoidal craniosynostosis 0.710217159131376 0.6354385891934168 0.5251424069178703 1.0 0.992882079018774 3 P16435,P61978 2 +Hypoplasia of the uterus 0.4532131786069172 0.6352457512963597 0.5252681484834927 1.0 0.992882079018774 9 Q16740 1 +Inguinal hernia 0.3147860907926719 0.6351295356222492 0.5253439353263283 1.0 0.992882079018774 67 P16278,Q32P28,Q15022,Q96ST3,Q15555,Q9Y487,Q9UJX6,P30153,Q10713,P21964,P08236,Q6PGP7,P07437,P36543,Q9BYW2,Q9UHX1,P46109 17 +Abnormal cerebral artery morphology 0.4006595659682584 0.6348462029810551 0.5255287263280883 1.0 0.992882079018774 14 P10253,Q9UBS4,P10644 3 +Bilateral microphthalmos 0.543562164292798 0.6336505770577248 0.5263088856939981 1.0 0.992882079018774 5 Q9UHX1 1 +Keratitis 0.4255343242274636 0.63263141794572 0.5269743653223635 1.0 0.992882079018774 11 P01889,P18074,Q14739,Q9NZ08 4 +Abnormal talus morphology 0.3766418249720417 0.6316404196080474 0.5276218684149692 1.0 0.992882079018774 20 P98175,Q99567,P18074,P16435,O75844,Q9UHX1 6 +Neoplasm of the ear 0.625996159232038 0.629990555878746 0.5287007632167391 1.0 0.992882079018774 4 Q9BYW2,Q9UJX6 2 +Pulmonary hypoplasia 0.340897609525067 0.6279850674689388 0.5300137221784396 1.0 0.992882079018774 25 O75844,Q5JTZ9,Q14739,P98175 4 +Emg neuropathic changes 0.3557293344425163 0.6279766955265907 0.530019206616136 1.0 0.992882079018774 23 O14773,P07602,Q16637,P04792,P22626 5 +Reduced subcutaneous adipose tissue 0.4515593631594319 0.6272838076617863 0.5304732155807632 1.0 0.992882079018774 9 O75844 1 +Lack of skin elasticity 0.3969284710914627 0.6264035377601828 0.531050289691394 1.0 0.992882079018774 15 O75844,P40818 2 +Abnormal labia minora morphology 0.4949201224027284 0.6250132215127958 0.531962380564365 1.0 0.992882079018774 6 Q9Y619 1 +Inflammation of the large intestine 0.4379324513401431 0.6249874036929502 0.5319793253625869 1.0 0.992882079018774 10 P01889,P49327,P49748,P08183,Q6PGP7 5 +Decreased circulating copper concentration 0.7061475237206035 0.6221619256564418 0.533835399038399 1.0 0.992882079018774 3 Q15904 1 +Aplasia hypoplasia of the nails 0.3140608156849207 0.6215328814446741 0.5342490667753323 1.0 0.992882079018774 57 Q15022,Q9BYW2,Q14739,Q9Y487,P18074,Q969G3,Q9UJX6,O14936,P23786,Q08J23,O75844,P46109,Q9C0B1 13 +Anonychia 0.4156487131264962 0.6214957381451871 0.5342734977558394 1.0 0.992882079018774 12 O14936,Q14739,P46109 3 +Abnormality of the nasal alae 0.3144904440995364 0.6196067608318219 0.535516714548181 1.0 0.992882079018774 145 Q15392,Q10713,O60216,P10644,P40855,P36543,Q08J23,Q9C0B1,P16278,Q7LGA3,P11233,Q9Y487,P18074,O95831,O43924,P55795,Q53EZ4,Q9UHX1,P46109,P10586,O15344,P29372,O75179,Q8WXW3,Q15555,Q969G3,P16435,P61978,Q6PGP7,P04062,Q96ST3,P98175,Q5KU26,P30153,Q02750,Q99496,P35573,Q96GM5,O94992,O43292,O14936 41 +Squamous cell carcinoma of the skin 0.5398765642999657 0.6194976954298971 0.5355885396401487 1.0 0.992882079018774 5 P18074,Q9H4L7 2 +Hypothalamic hypothyroidism 0.7048928541608415 0.6180850197675739 0.536519296461794 1.0 0.992882079018774 3 Q969G3 1 +Progressive pulmonary function impairment 0.7048928541608415 0.6180850197675739 0.536519296461794 1.0 0.992882079018774 3 Q969G3 1 +Ear pain 0.7048928541608415 0.6180850197675739 0.536519296461794 1.0 0.992882079018774 3 Q969G3 1 +Intracranial meningioma 0.7048928541608415 0.6180850197675739 0.536519296461794 1.0 0.992882079018774 3 Q969G3 1 +Visual acuity test abnormality 0.7048928541608415 0.6180850197675739 0.536519296461794 1.0 0.992882079018774 3 Q969G3 1 +Brain stem compression 0.7048928541608415 0.6180850197675739 0.536519296461794 1.0 0.992882079018774 3 Q969G3 1 +Transient global amnesia 0.7048928541608415 0.6180850197675739 0.536519296461794 1.0 0.992882079018774 3 Q969G3 1 +Decreased circulating follicle stimulating hormone concentration 0.7048928541608415 0.6180850197675739 0.536519296461794 1.0 0.992882079018774 3 Q969G3 1 +Abnormal central sensory function 0.7048928541608415 0.6180850197675739 0.536519296461794 1.0 0.992882079018774 3 Q969G3 1 +Neuralgia 0.7048928541608415 0.6180850197675739 0.536519296461794 1.0 0.992882079018774 3 Q969G3 1 +Decreased circulating gonadotropin concentration 0.7048928541608415 0.6180850197675739 0.536519296461794 1.0 0.992882079018774 3 Q969G3 1 +Abnormal protein o linked glycosylation 0.6225210824952288 0.617893743062726 0.5366453837341321 1.0 0.992882079018774 4 Q8N511 1 +Increased circulating igg level 0.6220460977639026 0.6162449518115033 0.5377328644288866 1.0 0.993889514206469 4 P15260 1 +Large face 0.3140094609222271 0.6158617572269807 0.5379857635527983 1.0 0.993889514206469 60 Q7LGA3,Q8WXW3,Q06787,P42858,Q9UJX6,O43924,Q02750,Q10713,P21964,P61978,Q96PZ0,Q08J23,O95721,Q96ST3,Q9BYW2,P46109 16 +Bulbar palsy 0.4145736430342213 0.6157193049751121 0.5380797938016393 1.0 0.993889514206469 12 P35637,Q13501,P43243,P31483 4 +Abnormal platelet volume 0.4694018059773991 0.6149308482341023 0.5386003894839382 1.0 0.993889514206469 7 Q14739 1 +Abnormal placental membrane morphology 0.6654804270462635 0.6147292432539713 0.5387335440883967 1.0 0.993889514206469 2 Q9H4L7 1 +Ectodermal dysplasia 0.6654804270462635 0.6147292432539713 0.5387335440883967 1.0 0.993889514206469 2 Q9H4L7 1 +Coxa valga 0.3847045342438167 0.6137741050989096 0.5393646111019677 1.0 0.9943675877179592 18 P16278,O75844,P04066,Q9Y619 4 +Somatic sensory dysfunction 0.2964274083883255 0.6131507868308922 0.539776641777967 1.0 0.9943675877179592 86 O14773,P07602,Q96IJ6,Q8IV08,P01889,Q8N0X7,P06280,O15270,Q9Y619,P54802 10 +Renal hypoplasia 0.3379136825010613 0.6122441170313917 0.5403762568292425 1.0 0.994477660077336 32 O43924,O60216,P21964,Q53EZ4,Q6PGP7,Q9UHX1 6 +Abnormal abdomen morphology 0.3260892244758364 0.6097078567679325 0.5420553490623654 1.0 0.9944859013095576 191 Q96CU9,P15260,P14174,Q15392,P08236,P16278,O43676,P01889,P21266,P10619,O43772,P09601,Q9Y619,O15118,P54802,Q14108,P04062,Q06124,Q14739,P07602,P31751,Q9Y285,P28070,Q9Y6M9,Q15437,Q15904,O75306,P00374,O14936 29 +Blepharophimosis 0.3298228379793333 0.6094150215015466 0.5422493836230802 1.0 0.9944859013095576 44 Q7LGA3,Q15555,P42858,P38159,Q9Y619,Q96PZ0,Q08J23,P07437,Q03164,O75844,P46109 11 +Long toe 0.4581359538830867 0.6086552365421903 0.5427529835630964 1.0 0.9944859013095576 8 O60762,Q9UHX1,P23786,P10644 4 +Stereotypy 0.31321060057664 0.6065121879972278 0.5441746914866936 1.0 0.9944859013095576 61 P61916,O14646,Q01105,Q06787,P55795,Q4G0J3,Q96C86,O96028,Q96N66,Q08J23,Q03164,Q9UHX1,Q13501,Q6IA86,Q7L7X3 15 +Malabsorption 0.3304042032083366 0.605887873759826 0.5445892123162488 1.0 0.9944859013095576 43 O76024,Q14739,P52701,P14174,P01889,P18074,Q9NZ08,P06280,P49327,P21266,P09601,Q08J23,P40855,P42345 14 +Female reproductive system neoplasm 0.383452230393959 0.6058827084431354 0.5445926425436949 1.0 0.9944859013095576 18 P21912,O60566,P52701,Q07864,P63167,Q15437,P10644,O96017 8 +Abnormality of humoral immunity 0.3283550319235684 0.6055863777752639 0.5447894503064388 1.0 0.9944859013095576 45 P15260,P14174,P09601,P21266,P28070,Q15904,Q14108,Q6PGP7,P04062 9 +Hypolipoproteinemia 0.4894992284453717 0.6024335749377944 0.5468855665096743 1.0 0.9944859013095576 6 P37268,Q15800 2 +Aplasia hypoplasia of the earlobes 0.4566911447069158 0.602014466188877 0.5471645080389644 1.0 0.9944859013095576 8 P21964,P98175 2 +Patellar aplasia 0.6998404787197126 0.6017477398986186 0.5473420667315727 1.0 0.9944859013095576 3 Q9Y619 1 +Abnormal cardiac ventricular function 0.3899174518108589 0.601407187755927 0.5475688124420266 1.0 0.9944859013095576 16 O75844,P10253,P21912 3 +Abnormality of the autonomic nervous system 0.3156876921137464 0.6012773827167267 0.5476552511860266 1.0 0.9944859013095576 53 Q8WXW3,Q06787,P07602,Q96IJ6,Q9UJX6,Q9Y3I1,Q15067,P06280,O60216,O15270,P21964,P42892,P04062,Q9BYW2 14 +Fever 0.3081858950294618 0.6007136539080027 0.5480307232729351 1.0 0.9944859013095576 74 P15260,P14174,P10644,P57740,Q6UN15,P01889,Q9NZ08,P06280,P10253,Q9BW27,P03886,P61978,Q14739,P07602,O14936,Q8NFH4,P28070,Q12769,P23786 19 +Infertility 0.4193199352731205 0.6001634248177367 0.5483973265002633 1.0 0.9944859013095576 11 Q02750,Q06124 2 +Abnormal circulating methionine concentration 0.4655110599133813 0.5977042051021316 0.5500373191160537 1.0 0.9944859013095576 7 Q9H3L0 1 +Cranial asymmetry 0.4882621844423275 0.5973046347358812 0.5503040106701906 1.0 0.9944859013095576 6 Q13363,O96028 2 +Bradykinesia 0.364956686765485 0.5965186211733082 0.5508288178572833 1.0 0.9944859013095576 21 Q06787,P42858,Q9Y3I1,Q5JPH6,Q6DKK2,Q96IX5,P04062 7 +Limb fasciculations 0.6157421139460191 0.5944712621575658 0.5521969577838288 1.0 0.9944859013095576 4 Q16637,P04792 2 +Hypopigmentation of the fundus 0.6974012103951737 0.5939069835851944 0.5525743278576374 1.0 0.9944859013095576 3 P38435,Q9Y619 2 +Congenital hip dislocation 0.3437182970183624 0.5928172397058168 0.5533034689765952 1.0 0.9944859013095576 24 Q9Y487,Q8TD16,P36543 3 +Abnormal aggressive impulsive or violent behavior 0.2867093390638826 0.5915507207079418 0.5541514812765715 1.0 0.9944859013095576 94 Q01105,Q10713,O75503,Q03164,P27635,P55795,O00462,Q969G3,Q4G0J3,Q12955,P23378,P54802,Q96ST3,Q9BYW2,Q13501,Q6IA86,Q7L7X3,P34897,Q06787,P42858,Q6DN90,Q9UJX6,Q96PZ0,Q6DKK2,O14936 25 +Abnormal basal ganglia mri signal intensity 0.343528885061396 0.591412623260804 0.554243984448711 1.0 0.9944859013095576 24 O75306,Q96CU9 2 +Aplasia hypoplasia of the skin 0.3199368273657084 0.5900548685257053 0.5551538647942511 1.0 0.9944859013095576 50 Q13126,O75844,Q15392,O96028 4 +Abnormal periventricular white matter morphology 0.3324164466514098 0.5896502531573332 0.5554251532125933 1.0 0.9944859013095576 35 O75648,P07602,P27635,P18074,Q13363,Q9Y285,Q5JTZ9,O96028,O75503,Q9UHX1,Q06330,P17900 12 +Gingival bleeding 0.417244289711112 0.5893841975655262 0.5556035746976156 1.0 0.9944859013095576 11 Q14108 1 +Bowing of the legs 0.3269024881013544 0.5820184636438231 0.5605542442611582 1.0 0.9944859013095576 44 P16278,Q32P28,O75718,Q8N0X7,Q02750,Q13126,Q9Y619,P08236,O75312 9 +Hepatoblastoma 0.4521738253430459 0.5813388691450134 0.5610120888927232 1.0 0.9944859013095576 8 Q969G3,Q6PGP7 2 +Arthrogryposis multiplex congenita 0.3310136917829466 0.5801625868031147 0.5618049809488084 1.0 0.9944859013095576 37 Q15392,Q8TD16,Q53EZ4,P04062,O75844,P42356 6 +Jaundice 0.3204276340370902 0.5794108310689651 0.5623119975603155 1.0 0.9944859013095576 49 P61916,O75648,Q14739,Q9UJS0,Q9UJX6,Q16134,Q15904,O15118,Q15437,P10644,P40855,Q6PGP7,Q9BYW2,P00374,O14936,Q00059 16 +Increased arm span 0.6924464631291551 0.5780773603764999 0.5632118912190589 1.0 0.9944859013095576 3 Q9BYW2 1 +Abnormal arm span 0.6924464631291551 0.5780773603764999 0.5632118912190589 1.0 0.9944859013095576 3 Q9BYW2 1 +Abnormal proportion of cd8 positive t cells 0.6540925266903934 0.5746813513692935 0.5655068219633217 1.0 0.9944859013095576 2 P49327 1 +Membranoproliferative glomerulonephritis 0.6540925266903879 0.5746813513692752 0.5655068219633341 1.0 0.9944859013095576 2 Q03252 1 +Retrognathia 0.309758343857519 0.5741114142241093 0.5658924098388627 1.0 0.9944859013095576 66 P78318,Q7LGA3,Q15022,O75844,Q99567,P27635,Q15392,Q13363,Q9Y619,Q53EZ4,Q96PZ0,P04062,Q96ST3,P37268,Q9UHX1,Q9C0B1 16 +Multiple mitochondrial dna deletions 0.6537366548042685 0.5734447418295813 0.5663436035473586 1.0 0.9944859013095576 2 Q96RR1 1 +Nocturia 0.6537366548042685 0.5734447418295813 0.5663436035473586 1.0 0.9944859013095576 2 Q96RR1 1 +Central hypoventilation 0.4823316779916167 0.5728449333575858 0.5667496922137054 1.0 0.9944859013095576 6 Q8N183,O75306 2 +Acetabular dysplasia 0.4400759688271287 0.5724876051127492 0.566991680695343 1.0 0.9944859013095576 9 P08236 1 +Abnormal shape of the palpebral fissure 0.4138228572405975 0.5716920339877462 0.5675306321502576 1.0 0.9944859013095576 11 O14646,Q9UHX1,O75179,P55795 4 +Brachydactyly 0.3096529058353556 0.5704604160810599 0.5683654625020291 1.0 0.9944859013095576 65 Q14739,P21912,O43924,Q8N0X7,O60216,Q02750,P48449,Q53EZ4,Q15437,Q06136,Q08J23,Q9UHX1,Q96C86,Q06124 14 +Abnormal ovarian physiology 0.3476039213141427 0.5693955790136612 0.569087716397132 1.0 0.9944859013095576 23 Q06787,P40818,P49327,Q96RR1,Q5JTZ9,Q9BZH6,O75844,P57740,Q9H1A4 9 +Macrodontia of permanent maxillary central incisor 0.6523131672597852 0.5685076292336578 0.5696903267751181 1.0 0.9944859013095576 2 P21281 1 +Short columella 0.6523131672597842 0.5685076292336536 0.569690326775121 1.0 0.9944859013095576 2 P49454 1 +Abnormality of metacarpal epiphyses 0.5260505940164235 0.5670681591650458 0.5706678747397989 1.0 0.9944859013095576 5 Q13363,O96028 2 +Microretrognathia 0.3972753858705293 0.5665165247208221 0.5710427028122897 1.0 0.9944859013095576 13 Q53EZ4,Q9UHX1,Q96ST3 3 +Reticulocytosis 0.4120382044035296 0.5625026320401143 0.5737736108589178 1.0 0.9944859013095576 11 Q15437 1 +Disproportionate short trunk short stature 0.6062524447627798 0.5620956344184639 0.5740508625780407 1.0 0.9944859013095576 4 P16278 1 +Ulnar deviation of the wrist 0.6868487447157297 0.5603548274143018 0.5752374369564315 1.0 0.9944859013095576 3 P16278 1 +Abnormality of corneal size 0.3307577381472585 0.5590220952719425 0.5761466408425358 1.0 0.9944859013095576 33 Q15555,P18074,Q13363,O60216,O43505,O96028,P07437 7 +Antenatal onset 0.4370853395804704 0.5583687212866227 0.5765926270557884 1.0 0.9944859013095576 9 P27635,Q9Y285 2 +Cavum septum pellucidum 0.4110073742260508 0.5572073401861838 0.5773857752203542 1.0 0.9944859013095576 11 Q9BVA1,Q9UJX6,O96028,Q9BYW2 4 +Absent toe 0.3590764646199382 0.5566817159137767 0.5777449114126361 1.0 0.9944859013095576 21 Q7LGA3,P42858,Q13363,Q96PZ0,O96028,Q9UHX1,Q06330 7 +Aphthous ulcer 0.4783518410596613 0.5565556680705598 0.5778310500452679 1.0 0.9944859013095576 6 P01889,Q9NZ08 2 +Nephrotic syndrome 0.3319060393043911 0.5559219394876205 0.5782642193226928 1.0 0.9944859013095576 26 Q9BW27,P06280,Q14108,O95721,Q12769,P57740,Q9BW83 7 +Abnormal labia majora morphology 0.4240068025406192 0.5559014838732185 0.5782782037883751 1.0 0.9944859013095576 10 Q9Y619,O60216 2 +Hypoplastic labia majora 0.4240068025406192 0.5559014838732185 0.5782782037883751 1.0 0.9944859013095576 10 Q9Y619,O60216 2 +Abnormal exteroceptive sensation 0.3239069709296582 0.5540785543051867 0.579525086306496 1.0 0.9944859013095576 44 Q06787,P07602,P01889,O95831,Q9NZ08,O15270,P06280,P49327,P04792,P61978,P54802 11 +Hand clenching 0.4553851300988029 0.5533253994408208 0.5800406116994841 1.0 0.9944859013095576 7 P36543 1 +Cutaneous melanoma 0.684585261658959 0.553238693984867 0.5800999743320152 1.0 0.9944859013095576 3 P11802,Q99496 2 +Abnormal pharynx morphology 0.3315883234470737 0.5508293107972835 0.581750689262498 1.0 0.9944859013095576 29 P16278,O15344,P29372,Q13432,P01889,Q969G3,P54802,P08236,P43243,P13051 10 +Aplasia hypoplasia of the lungs 0.3312697463462778 0.5499568616148082 0.5823489620159255 1.0 0.9944859013095576 30 Q14739,P98175,Q5JTZ9,O96028,O75844 5 +Abnormality of the periorbital region 0.3080693940901821 0.5497599772869288 0.5824840130711335 1.0 0.9944859013095576 61 O14646,Q7LGA3,O75179,Q9BW27,P98175,Q8IWS0,Q02750,P38159,Q8NFH4,P28070,Q08J23,P40855,Q6PGP7,P07437,P57740,Q12769 16 +Curly hair 0.4225162288072094 0.5485956984655677 0.5832829384881197 1.0 0.9944859013095576 10 P55795,Q02750,Q6PGP7,P42345 4 +Abnormality of the menstrual cycle 0.3085950292771559 0.5476064116760823 0.5839621859450668 1.0 0.9944859013095576 54 Q9UJS0,O60216,P10644,P57740,Q6UN15,Q9BUK6,Q9BZH6,O75844,Q969G3,Q96RR1,P16435,Q9BYW2,Q16740,Q06124,Q06787,O00429,P31751,P40818,Q99496,Q9NR50 20 +Spastic diplegia 0.3512504715099492 0.5475201540022436 0.5840214281907423 1.0 0.9944859013095576 22 P35637,P07602,Q6IA86 3 +Increased circulating igm level 0.453676227555451 0.5459052119647347 0.5851310955102464 1.0 0.9944859013095576 7 P15260,P13051 2 +Hydrops fetalis 0.326825378245966 0.5437508401246163 0.5866129419638484 1.0 0.9944859013095576 37 P16278,P10619,P08236,P04062 4 +Cutis laxa 0.34397202993266 0.5435046525397098 0.5867823884003267 1.0 0.9944859013095576 23 Q15022,Q9Y487,Q02750,Q53EZ4,Q15904,P36543 6 +Leiomyosarcoma 0.4747636419525092 0.5419601869641134 0.5878459329902066 1.0 0.9944859013095576 6 P63167,O60566,O96017 3 +Sclerocornea 0.4746630356311028 0.5415522356970663 0.5881270037550905 1.0 0.9944859013095576 6 Q13363,O96028 2 +Emg axonal abnormality 0.6441281138790156 0.5404160039935517 0.5889101733299058 1.0 0.9944859013095576 2 Q92734 1 +Lymphocytosis 0.6803495688295907 0.5400019603074466 0.5891956805335197 1.0 0.9944859013095576 3 P49327 1 +Barrett esophagus 0.6799572801708854 0.5387813891895122 0.5900377066842126 1.0 0.9944859013095576 3 Q8N9N2,O60216 2 +Broad hallux phalanx 0.6434163701067594 0.5379977535736395 0.5905785994803692 1.0 0.9944859013095576 2 P49711 1 +Duplication involving bones of the feet 0.3682934745278738 0.5373311828878589 0.5910388694846782 1.0 0.9944859013095576 19 Q8WXW3,Q14739,Q13363,O43924,Q10713,P21964,O96028 7 +Aganglionic megacolon 0.3724431659818497 0.5372664042014442 0.5910836082467528 1.0 0.9944859013095576 18 Q8WXW3,Q9UJX6,P21964,P42892,Q9BYW2 5 +Cytochrome c oxidase negative muscle fibers 0.4735298105728825 0.5369619967069209 0.591293865134638 1.0 0.9944859013095576 6 O75648,Q9Y2R0 2 +Renal cell carcinoma 0.3623120661209963 0.5369619396862052 0.5912939045225594 1.0 0.9944859013095576 20 Q15437,P21912 2 +Short sternum 0.6788423867510819 0.535317515116718 0.5924303168067251 1.0 0.9944859013095576 3 P98175 1 +Abnormal bleeding 0.2847214569592925 0.5352238431535051 0.5924950808280662 1.0 0.9944859013095576 90 Q14739,P21912,Q9Y487,P01889,Q969G3,Q02750,Q13126,P21964,P11117,Q14108,P04062,O75844,P36543,Q9UHX1,Q06124 15 +Smooth philtrum 0.3063217516900784 0.5351738372252252 0.5925296558430877 1.0 0.9944859013095576 66 O60216,Q08J23,O75312,P36543,P57740,Q7LGA3,Q9Y487,P27635,Q9UHX1,P46109,P10586,O15344,P29372,O75179,Q9Y263,Q96ST3,P42858,Q96PZ0,O14936,P42345 20 +Abnormal emotion affect behavior 0.3234818239969306 0.5339594410445817 0.593369595556243 1.0 0.9944859013095576 211 Q01105,Q96CU9,Q10713,P35637,P10644,O75503,P43243,Q03164,P06865,P57740,P07737,P27635,P01889,O95831,P55795,Q9NZ08,P37268,Q9UHX1,Q92804,O00462,Q9BW27,P50897,P21912,Q9NVV4,P50995,Q969G3,Q8N0X7,Q15067,P49327,O43772,Q4G0J3,Q12955,P23378,P54802,Q12769,P04062,Q9BYW2,Q96ST3,Q8N183,Q13501,Q6IA86,Q7L7X3,P34897,Q06787,P07602,P52701,Q15165,Q6DN90,P42858,Q5KU26,Q9UJX6,Q8NFH4,Q99496,P40818,O94992,Q96PZ0,O75306,Q6DKK2,O14936,P17900 60 +Abnormality of the choanae 0.3267563337641205 0.5327885724331575 0.5941799452265286 1.0 0.9944859013095576 34 O60216,P21964,Q53EZ4,O75844,P42356,P46109 6 +Broad palm 0.4722858438848941 0.5319336607329875 0.5947719428587539 1.0 0.9944859013095576 6 Q14739,P10644 2 +Abnormality of the curvature of the vertebral column 0.3171115438384319 0.5318541394790802 0.594827022348908 1.0 0.9944859013095576 275 Q01105,Q96CU9,Q8TB36,O75874,Q99567,O75718,Q13363,Q8TD16,P04066,Q10713,O75477,P48449,P35637,P21964,O96028,P08236,P10644,Q08J23,P36543,Q96AY3,P57740,P22626,P16278,Q7LGA3,Q15022,P50402,P27635,Q9Y487,P18074,P55795,P01889,Q9BQP7,P51648,O75844,P48735,Q9UHX1,P46109,O75179,P21912,Q8WXW3,Q969G3,Q8N0X7,Q8IWS0,Q4G0J3,P61978,Q14108,P04062,Q9BYW2,Q96ST3,Q06124,Q32P28,Q7L7X3,P78318,Q14739,P98175,Q06787,P42858,Q5KU26,Q9UJX6,Q9Y285,P40818,Q02750,P30153,O94992,Q15437,Q96PZ0,O14936 67 +Abnormality of the 5th toe 0.4409677403311167 0.5306679716911353 0.5956488843458687 1.0 0.9944859013095576 8 Q14739,O43924,Q10713 3 +Abnormality of body mass index 0.6771462506517274 0.5300621138629911 0.5960688657559494 1.0 0.9944859013095576 3 P42858 1 +Hypergonadotropic hypogonadism 0.3776364501356063 0.5290318273799651 0.5967833713308734 1.0 0.9944859013095576 16 P48449,Q16740 2 +Punctate cataract 0.6767532929868255 0.5288470398431873 0.5969115630436375 1.0 0.9944859013095576 3 Q8WWV3,P08670 2 +Truncus arteriosus 0.4305205200786546 0.5276188593300665 0.5977639006271103 1.0 0.9944859013095576 9 P21964,Q9UHX1 2 +Elevated circulating alanine aminotransferase concentration 0.4493125006459509 0.5270549392386612 0.598155437265097 1.0 0.9944859013095576 7 Q15904 1 +Abnormal female reproductive system physiology 0.3060000306123719 0.5267313296972912 0.5983801759049685 1.0 0.9944859013095576 62 Q9UJS0,O60216,P10644,P57740,Q9H1A4,Q6UN15,P01889,Q9BUK6,O75844,Q969G3,P49327,P16435,Q5JTZ9,Q9BYW2,Q16740,Q06124,Q06787,O00429,P31751,P40818,Q99496 21 +Neoplasm 0.3210704174593852 0.5259174602720514 0.5989455569302626 1.0 0.9944859013095576 193 Q9UJS0,Q8N9N2,O75874,Q15392,Q13363,Q10713,O60216,Q13126,Q9UKG1,O96028,P10644,Q08J23,Q7LGA3,P27635,P18074,O43924,P48735,Q9UHX1,P46109,Q92804,P30154,P10619,P21912,Q15555,P11717,Q969G3,P49327,P16435,Q6PGP7,P42892,P04062,Q9BYW2,Q13501,Q92733,Q06124,Q01844,P07602,P52701,Q07954,Q9UJX6,P40818,Q02750,Q99496,Q96GM5,P17812,Q15437,Q06136,Q9UBS4,P07437,P53634,P42345 51 +Mixed demyelinating and axonal polyneuropathy 0.6754384340544 0.5247881899986848 0.5997304423466696 1.0 0.9944859013095576 3 P03886 1 +Uveal melanoma 0.6395017793594332 0.5247696070803147 0.59974336206882 1.0 0.9944859013095576 2 Q99496 1 +Choroidal melanoma 0.6395017793594332 0.5247696070803147 0.59974336206882 1.0 0.9944859013095576 2 Q99496 1 +Ocular pain 0.6395017793594332 0.5247696070803147 0.59974336206882 1.0 0.9944859013095576 2 Q99496 1 +Photopsia 0.6395017793594332 0.5247696070803147 0.59974336206882 1.0 0.9944859013095576 2 Q99496 1 +Inferior lens subluxation 0.6395017793594332 0.5247696070803147 0.59974336206882 1.0 0.9944859013095576 2 Q99496 1 +Abnormal ciliary body morphology 0.6395017793594332 0.5247696070803147 0.59974336206882 1.0 0.9944859013095576 2 Q99496 1 +Metamorphopsia 0.6395017793594332 0.5247696070803147 0.59974336206882 1.0 0.9944859013095576 2 Q99496 1 +Mydriasis 0.6395017793594332 0.5247696070803147 0.59974336206882 1.0 0.9944859013095576 2 Q99496 1 +Erythroid hyperplasia 0.6395017793594282 0.5247696070802991 0.5997433620688308 1.0 0.9944859013095576 2 Q86SX6 1 +Prominent nose 0.3810967776536176 0.5246209836567781 0.5998466966224605 1.0 0.9944859013095576 14 Q9UJX6,Q8N0X7,Q08J23 3 +Keratoconjunctivitis 0.4297933860722726 0.5242344593040082 0.6001154761114289 1.0 0.9944859013095576 9 P01889,P18074,Q14739,Q9NZ08 4 +Abnormality of hindbrain morphology 0.3226652864170548 0.5205018628535091 0.6027138298531178 1.0 0.9944859013095576 236 Q96CU9,Q96B26,Q8TD16,O60216,P35637,Q9NXN4,O96028,Q8NHS3,O75503,P36543,O75312,Q5JRX3,Q9Y487,Q96BR5,O43924,P55795,O43505,Q9BQP7,Q53EZ4,Q8WXW3,P21912,Q8IV08,Q969G3,Q8N0X7,Q5JTZ9,Q14108,Q9BYW2,Q06787,O14773,P98175,P42858,Q8NFH4,Q96D71,Q15437,P23786,P00374,P07437,Q6DKK2,Q9BVA1,P42356,O14936 41 +High anterior hairline 0.3596567126984954 0.5197081309311771 0.603267018899563 1.0 0.9944859013095576 20 O15344,Q7LGA3,O75179,Q13363,O96028,Q96ST3,Q9BYW2 7 +Simple ear 0.6736051977323415 0.5191469235820737 0.6036582884083075 1.0 0.9947670588139824 3 P16435 1 +Relative macrocephaly 0.3262089542232058 0.5160926316331422 0.6057897139910802 1.0 0.9961687852482451 32 Q7LGA3,P42858,Q15392,Q96PZ0,O75844 5 +Fine hair 0.3955928488199083 0.5153987073219566 0.6062744356018395 1.0 0.9961687852482451 12 Q15022,Q02750,Q6PGP7,Q08J23,Q96ST3 5 +Abnormal glycosylation 0.3646623979461132 0.5143689016236822 0.6069940973949095 1.0 0.9961687852482451 19 Q9Y487,Q8N511,P36543 3 +Postaxial foot polydactyly 0.4460849887829405 0.5132063966225063 0.6078069519310914 1.0 0.9961687852482451 7 Q14739,O43924,Q10713 3 +Resting tremor 0.3719996201584981 0.5131936437377186 0.6078158717801152 1.0 0.9961687852482451 17 P04062 1 +Simplified gyral pattern 0.3257542442761977 0.512883927376048 0.6080325170170684 1.0 0.9961687852482451 25 Q5KU26,Q86XL3,Q03252,Q969G3,Q96GM5,O94992,O14936 7 +Protruding ear 0.3221304588884293 0.5119430172522256 0.6086908905572694 1.0 0.9964218558499012 40 O43505,P61978,Q06136,Q08J23,Q06124 5 +Increased head circumference 0.2841643796050301 0.5115074482200844 0.608995774314681 1.0 0.9964218558499012 99 O14646,Q15392,Q8TD16,Q10713,P08236,P40855,Q7LGA3,Q15022,O43505,O75844,O75179,P21912,Q8IWS0,Q12955,Q9BYW2,P78318,Q14739,Q06787,P07602,P42858,Q9UJX6,Q02750,Q15437,Q96PZ0,P42345 25 +Small hand 0.3263070155051347 0.5105240785139644 0.6096843499804909 1.0 0.9970418597104764 30 Q06787,P42858,Q99496,O60216,Q9Y619,Q08J23,Q14671,Q96ST3 8 +Hemiplegia hemiparesis 0.3253413991834625 0.509063023480888 0.610708049094387 1.0 0.9975237488582558 32 O00429,P52701,P01889,Q969G3,Q9NZ08,P49327,P03886,Q9BVA1,P57740,Q06330,P42345 11 +Abnormality of coordination 0.3142613729522409 0.508840066545357 0.6108643325601921 1.0 0.9975237488582558 281 Q96CU9,P35637,O96028,Q8NHS3,O75503,Q5JRX3,P16278,O00584,O43676,Q9Y287,Q9Y487,Q96IJ6,P01889,O43924,P55795,P50897,P21912,Q8IV08,Q9H3L0,Q969G3,Q8N0X7,Q9Y619,Q5JTZ9,O15118,Q14108,P04062,O14773,P07602,P42858,Q96D71,Q9Y6M9,Q15437,O75306,P00374,P07437,Q6DKK2,Q9BVA1,O14936 38 +Hepatic failure 0.3219669344595653 0.5066914283700316 0.6123713458104392 1.0 0.9984608447404674 39 O75648,Q16836,P01889,O43772,Q10713,Q9Y619,P03886,O15118,P23786,Q6PGP7,P40855,P04062,P22830,Q00059 14 +Renal agenesis 0.3099673029890371 0.5064427502597714 0.6125458699151081 1.0 0.9984608447404674 51 Q15392,Q86XL3,O43924,O75306,Q06124 5 +Limb pain 0.4352256016636808 0.5050796017382009 0.6135029277264858 1.0 0.9988894760055508 8 O15270 1 +Prominent supraorbital ridges 0.4256001873285127 0.5048056405821257 0.6136953536852385 1.0 0.9988894760055508 9 Q8IWS0,P38159 2 +Variable expressivity 0.3035397813444939 0.5038850402063821 0.6143421636600497 1.0 0.999220545512755 66 P07602,Q70HW3,Q8TD16,Q9H061,P00374,Q9BVA1,P17900 7 +Abnormal circulating protein concentration 0.300150473550003 0.5020982043568254 0.6155984432362409 1.0 1.0 130 Q92734,P15260,P14174,Q14126,O14979,Q9UKG1,Q08J23,P43243,P36543,P57740,P53985,Q5JRX3,P22626,P50402,Q9Y487,Q96BR5,O95831,O43505,Q9BQP7,P10253,P31483,Q8N511,Q9BW27,O43772,Q6PGP7,Q13501,Q16836,Q9Y285,Q8NFH4,P35573,P47985,Q12769,P23786,Q00059 34 +Unilateral renal agenesis 0.3624897088475357 0.5007180862468011 0.6165695417171695 1.0 1.0 19 Q7LGA3,O75179,P30153,Q86XL3,P10644,Q9UHX1,Q06124 7 +Microcytic anemia 0.4431335147804152 0.5006149339160918 0.6166421502178665 1.0 1.0 7 Q9Y285 1 +Regional abnormality of skin 0.2945396441877587 0.4987550406185632 0.6179519641821343 1.0 1.0 119 Q99567,Q13363,Q14126,O60216,Q96AY3,O96028,P40855,P57740,P07858,Q7LGA3,Q96IJ6,P27635,Q9Y487,P18074,P55795,Q53EZ4,O95721,Q9UHX1,P21912,P61978,Q9Y263,Q96ST3,P42166,Q06124,Q14739,P98175,P42858,Q02750,Q15437,Q06136,Q96PZ0,P42345 32 +Esophageal neoplasm 0.4639825369060987 0.4986624049769128 0.6180172338496479 1.0 1.0 6 P21912,O60216 2 +Plantar hyperkeratosis 0.3243969280845636 0.4977649722006029 0.6186497073979673 1.0 1.0 31 P21912,Q96IJ6,Q15437,Q06136,O95721 5 +Colitis 0.442339275760802 0.4972387682347036 0.6190206856676779 1.0 1.0 7 P49327,Q6PGP7,P49748 3 +Abnormality of the calf 0.3055630628190364 0.4965986012466255 0.6194721397223097 1.0 1.0 53 P16278,Q32P28,O75718,Q8N0X7,Q02750,Q13126,Q9Y619,P08236,O75312 9 +Abnormality of retinal pigmentation 0.302953938767049 0.4934339340382759 0.6217060101131384 1.0 1.0 63 Q96CU9,P21912,Q15555,Q13432,Q16836,P18074,Q15067,P03886,P51648,O75306,Q8NHS3,P40855,Q6P4Q7,Q8N183,Q9BW83 15 +Spastic tetraparesis 0.3493590898381826 0.4919053465142135 0.6227862585064745 1.0 1.0 21 P21912,P07602,P17900 3 +Blepharitis 0.3833334392395616 0.4916407266276566 0.6229733471794141 1.0 1.0 13 Q15800,O60216 2 +Gastrointestinal obstruction 0.3909022250061208 0.4911592350948675 0.6233138285170721 1.0 1.0 12 P21912,P42892 2 +Molar tooth sign on mri 0.5848052610182787 0.4909004959447411 0.6234968262734697 1.0 1.0 4 Q8WXW3,O43924 2 +Posterior pituitary dysgenesis 0.5847462158681885 0.4907086008991494 0.623632562389673 1.0 1.0 4 Q9UHX1,P42356 2 +Teratoma 0.6641816953254733 0.4904846897477414 0.6237909611161196 1.0 1.0 3 Q9BYW2 1 +Urethral valve 0.6641816953254733 0.4904846897477414 0.6237909611161196 1.0 1.0 3 Q9BYW2 1 +Congenital posterior urethral valve 0.6641816953254733 0.4904846897477414 0.6237909611161196 1.0 1.0 3 Q9BYW2 1 +Nasal speech 0.3238339352673087 0.4901180177385275 0.6240503889779727 1.0 1.0 29 P42858,Q96IJ6,Q9Y487,Q9BQP7,P21964,Q96PZ0 6 +Intrauterine growth retardation 0.3151990111555192 0.4900289926100545 0.6241133830923309 1.0 1.0 175 Q96CU9,Q99567,Q15392,Q13363,O60216,P21964,Q9UKG1,O96028,P10644,Q08J23,P36543,Q03164,O75312,P57740,Q9C0B1,P16278,O43676,P27635,Q9Y487,O43924,O75844,P37268,Q9UHX1,P46109,P21912,Q969G3,Q9Y619,P03886,Q6PGP7,P04062,Q96ST3,Q8N183,Q06124,Q06787,P98175,Q16836,O75306,P47985,P42356,Q9Y6M9,Q00059 41 +Stuttering 0.6631017320783492 0.4872368171482427 0.626090517187758 1.0 1.0 3 P03886 1 +Hyperconvex fingernails 0.5043167211060474 0.4870786660642005 0.6262025843235253 1.0 1.0 5 O96028 1 +Occipital meningocele 0.5041942022307481 0.4866371882281131 0.6265154647639029 1.0 1.0 5 P21964 1 +Neoplasm of the rectum 0.3897515855296584 0.4852508287535336 0.6274984305400089 1.0 1.0 12 Q15437 1 +Abnormal consumption behavior 0.3421430637051606 0.4852467927930536 0.6275012931098114 1.0 1.0 22 O76024,P42858,Q969G3,Q4G0J3,Q96GM5,Q9BYW2,Q6IA86 7 +Abnormal circulating follicle stimulating hormone concentration 0.4388640306611615 0.4825286508096039 0.6294304504581709 1.0 1.0 7 P16435,Q969G3 2 +Vocal cord paresis 0.5819065121717434 0.4815079916083888 0.6301555012834834 1.0 1.0 4 Q8TB36 1 +Abnormality of cranial sutures 0.2981045315180193 0.4802603707155066 0.6310422640856295 1.0 1.0 74 O75718,P21964,Q96AY3,Q08J23,P40855,P36543,Q9Y487,P18074,O95831,O75844,P16435,Q9Y619,P61978,Q9BYW2,Q32P28,P98175,Q9UJX6,P30153,Q96GM5 19 +Episodic tachypnea 0.4295238172884793 0.4799484869326889 0.6312640226274282 1.0 1.0 8 Q8WXW3,O43924,Q10713 3 +Hypoplastic fifth toenail 0.4380142961053311 0.4789476643202738 0.6319758610420072 1.0 1.0 7 Q969G3 1 +Pituitary growth hormone cell adenoma 0.5809209621804022 0.4783279298257951 0.6324168204016669 1.0 1.0 4 Q9UBS4 1 +Abnormal circulating aspartate family amino acid concentration 0.4284574907312454 0.4752808473109052 0.6345868085724806 1.0 1.0 8 Q9H3L0 1 +Abnormal circulating sulfur amino acid concentration 0.4284574907312454 0.4752808473109052 0.6345868085724806 1.0 1.0 8 Q9H3L0 1 +Cns demyelination 0.3877073463315055 0.4747918903613355 0.6349353138284202 1.0 1.0 12 P51648,Q15067,P07602 3 +Flared nostrils 0.5008501386577493 0.4746315291626136 0.6350496292868226 1.0 1.0 5 O75179 1 +Thickened calvaria 0.4569476809068741 0.4708962887750585 0.6377147984099654 1.0 1.0 6 P16278 1 +Atrioventricular canal defect 0.4359267611176052 0.4701772930622243 0.6382283556994452 1.0 1.0 7 Q06124 1 +Dental crowding 0.3267845696168181 0.4694650564004011 0.6387372563994682 1.0 1.0 24 O75844,P36543 2 +Abnormality of prenatal development or birth 0.3188238070542216 0.4669147986382662 0.64056083706858 1.0 1.0 205 Q96CU9,Q16637,O75718,Q70HW3,Q8TD16,O60216,P21964,O96028,P08236,P57740,P16278,P61916,Q7LGA3,O43676,Q9Y487,Q53EZ4,O75844,P51114,Q9UHX1,P46109,P10619,O43772,Q9Y619,P03886,O15118,P61978,Q6PGP7,P04062,Q96ST3,Q8N183,Q06124,Q14739,Q9Y285,Q02750,O75306,P23786,Q9Y6M9 37 +Difficulty walking 0.3003784821669603 0.4668712740764435 0.6405919785118135 1.0 1.0 65 Q8TD16,O75477,P35637,P43243,P49588,Q9BUK6,P31483,Q05639,Q15067,Q969G3,Q8N0X7,Q13501,O00429,P07602,O14773,P42858,Q99496,P04792,O43292 19 +Preaxial hand polydactyly 0.4558998406824138 0.466795654643955 0.6406460850590263 1.0 1.0 6 Q9UHX1,O96028 2 +Basal cell carcinoma 0.4055329719981787 0.4667763101515552 0.6406599265658544 1.0 1.0 10 P52701,Q16658,P18074,P49327,P19447,Q9H1A4 6 +Lung adenocarcinoma 0.6557383857376617 0.4653025457003918 0.6417148120137628 1.0 1.0 3 P30154 1 +Muscle fiber necrosis 0.6213523131672571 0.4651221527995921 0.6418439826944136 1.0 1.0 2 Q96RR1 1 +Progressive 0.2810765881259852 0.4648915805501091 0.6420091001731167 1.0 1.0 89 Q16637,O75477,Q13126,P57740,O95831,Q9BQP7,Q14671,Q9BW27,Q9NR28,Q5JTZ9,P54802,P04062,Q8N183,Q13501,Q6IA86,Q02750,Q96D71,Q9UBS4,Q12769,Q9Y6M9,Q00059 21 +Corneal erosion 0.5766435738093211 0.4646060072720887 0.6422136295435159 1.0 1.0 4 P01889 1 +Abnormal circulating estrogen level 0.3924338088562226 0.4635550275683022 0.6429665814128986 1.0 1.0 11 P16435,P57740,Q969G3 3 +Flat nasal alae 0.6548738964534491 0.4627518870303882 0.6435422215931623 1.0 1.0 3 P18074 1 +Abnormality of amino acid metabolism 0.6548738964534491 0.4627518870303882 0.6435422215931623 1.0 1.0 3 P18074 1 +Motor seizure 0.2774797798340545 0.4617845693462553 0.6442358175708562 1.0 1.0 94 P16278,Q01105,P21912,P07602,Q9Y619,Q8NHS3,O75503,Q08J23,P04062,Q9BYW2,P42356,O14936,Q9UBX3,Q96C86,Q7L7X3 15 +Conspicuously happy disposition 0.6534959896981096 0.4586972648592997 0.6464515784561917 1.0 1.0 3 P55795 1 +Reduced circulating prolactin concentration 0.5747213684982334 0.458482578556055 0.646605775948081 1.0 1.0 4 Q969G3 1 +Abnormal larynx physiology 0.3652683519901474 0.4580416930972901 0.6469224875730419 1.0 1.0 16 Q15165,P50995,P35637,P07737,Q13501,Q92804 6 +Triangular mouth 0.4961367692014929 0.4578581232735429 0.6470543744672281 1.0 1.0 5 P18074,Q10713 2 +Diminished ability to concentrate 0.6188612099644101 0.4571632971404845 0.6475536770311265 1.0 1.0 2 Q96RR1 1 +Late onset 0.4151001357681222 0.4568598002231038 0.6477718199240206 1.0 1.0 9 P31483,Q9Y6M1,P31751 3 +Cough 0.3378575103749029 0.4564248509060702 0.6480844989055452 1.0 1.0 22 P01889,Q9Y285,P04062 3 +Hepatitis 0.3684684242847221 0.4558182138443308 0.6485207054687372 1.0 1.0 14 Q9Y619,P08236 2 +Abnormality of the parathyroid gland 0.3493740121291904 0.4539054460610311 0.6498968835884589 1.0 1.0 20 P21964,P48735,O75874 3 +Phimosis 0.5731465560592957 0.453486078010208 0.6501987660243824 1.0 1.0 4 Q9BYW2 1 +Abnormality of extrapyramidal motor function 0.2978542127689597 0.4533565510350695 0.6502920177314064 1.0 1.0 70 P16278,P98175,P07602,P42858,P35637,Q6DKK2,P06865,P04062 8 +Polyneuropathy 0.361683124429657 0.4526173609607626 0.6508242953170189 1.0 1.0 17 P03886,O95721,P04066,P07602 4 +Chromosome breakage 0.4020909540670889 0.4505454933252482 0.6523171587639665 1.0 1.0 10 Q06787,Q969G3 2 +Neonatal death 0.3829240365892414 0.4505162210453518 0.65233826061177 1.0 1.0 12 Q14739,P04062 2 +Abnormality of the ankles 0.3154691237215806 0.4504302520086262 0.6524002357167635 1.0 1.0 39 Q9BYW2,P07602,P42858,Q9UJX6,Q8N0X7,Q96AY3,O75844 7 +Abnormality of the mitochondrion 0.2915918881384474 0.4482170994508165 0.6539965231797846 1.0 1.0 79 Q96CU9,O43676,Q70HW3,O43772,P35637,O75306,Q9UBX3,Q9Y2R0 8 +Nuclear cataract 0.4929319240176329 0.4465554817935197 0.6551960449217962 1.0 1.0 5 O76024,P08670 2 +Fasting hyperinsulinemia 0.5704715717693476 0.4450414484994113 0.6562898008520914 1.0 1.0 4 P00367,Q16836 2 +Lactose intolerance 0.6477254770873044 0.4418644016563749 0.6585873320649156 1.0 1.0 3 P42345 1 +Thoracic aortic aneurysm 0.3169398364456836 0.4417997947041138 0.6586340871429486 1.0 1.0 32 Q06787,P42858,P01889,Q96PZ0,Q9UBS4,O75844 6 +Corneal neovascularization 0.4910819413519621 0.4400698932254666 0.6598864865496317 1.0 1.0 5 P21964 1 +Infectious encephalitis 0.4202311683765419 0.439634679474347 0.6602017191929255 1.0 1.0 8 P01889,Q14739,Q9NZ08 3 +Abnormality of the cerebrospinal fluid 0.2896895536214421 0.4374929683064998 0.6617538745218754 1.0 1.0 118 Q96CU9,Q15392,Q13363,Q10713,P21964,O96028,P08236,P10644,P40855,Q08J23,O75312,Q9C0B1,O43676,P18074,O95831,O43505,Q8WXW3,Q969G3,P03886,P04062,Q8N183,P07602,P30153,Q02750,O75306,P23786,Q9Y6M9 27 +Abnormality of chromosome stability 0.3870986639056021 0.4373472373487512 0.6618595425785805 1.0 1.0 11 Q06787,Q969G3 2 +Broad foot 0.4189340543597569 0.4340751473272628 0.6642338721108192 1.0 1.0 8 P27635,Q15022,Q8IWS0 3 +Bundle branch block 0.363971443893041 0.4318509261721199 0.6658497635772402 1.0 1.0 14 Q06124,P36543 2 +Macrotia 0.2965663168296467 0.4312962419782227 0.6662529825170851 1.0 1.0 68 P16278,Q01105,Q7LGA3,Q15022,Q06787,P42858,Q8IWS0,Q02750,O60216,P38159,P48449,Q96PZ0,O95721,Q96ST3,P37268,P57740,O14936 17 +Limb girdle muscle atrophy 0.3858460694360205 0.4312442434624072 0.6662907869667727 1.0 1.0 11 O14979 1 +Abnormality of the phalanges of the hallux 0.6436454254183018 0.4301095743459694 0.6671159357090677 1.0 1.0 3 Q9ULC3,P49711 2 +Spinal rigidity 0.3784918289965934 0.4282818722065507 0.6684459152584328 1.0 1.0 12 Q9BQP7 1 +Muscle spasm 0.3018994125866763 0.4268178975022719 0.6695119695549341 1.0 1.0 51 Q92734,Q16637,Q15165,P50995,P06280,P04792,P35637,P23786,P07737,P04062,P53985,Q13501,Q92804 13 +Slender finger 0.3130112838356372 0.4264279077454577 0.6697960693495268 1.0 1.0 35 Q9Y285,Q13363,P55795,Q969G3,P21964,P16435,O96028,Q96ST3,P57740,P46109 10 +Chromosomal breakage induced by ionizing radiation 0.5644858304395327 0.4263434293883805 0.6698576163827403 1.0 1.0 4 Q969G3 1 +Eeg with polyspike wave complexes 0.4252282852444858 0.4258638465257757 0.6702070603318142 1.0 1.0 7 Q14108 1 +Delayed eruption of permanent teeth 0.4868380842090612 0.4253021597746231 0.6706164193239779 1.0 1.0 5 Q9BYW2 1 +Titubation 0.4168661665773834 0.4252479694509015 0.6706559185694736 1.0 1.0 8 P35637 1 +Abnormal myocardium morphology 0.3026850484268894 0.4238431066631058 0.6716802383474887 1.0 1.0 149 Q96CU9,P08236,P13807,P57740,P22626,Q9C0B1,P16278,P50402,O43676,P01889,P06280,Q9BQP7,Q9H061,P10253,P48735,P21912,O43772,Q5JTZ9,P54802,Q14108,P04062,Q06124,Q16836,Q02750,P35573,O75306,P47985,P23786,Q9Y6M9 29 +Choroid plexus cyst 0.607473309608536 0.4215288934121998 0.673368917265823 1.0 1.0 2 P07954 1 +Unusual infection by anatomical site 0.3957435426755221 0.4209625826457716 0.6737824049109651 1.0 1.0 10 P01889,Q14739,Q9NZ08,P49327 4 +Lens subluxation 0.6397294410822442 0.4189449657238527 0.6752563536181402 1.0 1.0 3 Q9Y467,Q99496 2 +Early onset of sexual maturation 0.3106612634234662 0.4158828950939325 0.6774956965607903 1.0 1.0 41 O75874,P42858,Q96PZ0,O96028,P48735,O14936 6 +Hernia 0.2865137173673756 0.4154013071885633 0.677848149899658 1.0 1.0 115 Q13363,P04066,Q10713,O60216,P21964,O96028,P08236,P36543,P57740,Q9C0B1,P16278,Q15022,P27635,Q9Y487,Q9UHX1,P46109,Q15555,Q969G3,Q6PGP7,Q96ST3,Q9BYW2,Q32P28,Q14739,Q9UJX6,P30153,P07437,O14936,P42345 28 +Progressive sensorineural hearing impairment 0.3942636117639938 0.4141331701565928 0.6787765816374363 1.0 1.0 10 P03886,O60443 2 +Pectus carinatum 0.3132244553907328 0.4125700309010545 0.6799216621287392 1.0 1.0 32 P16278,P55795,Q02750,Q9Y619,P08236,Q06124 6 +Decreased adipose tissue 0.358686581595843 0.4108856258564042 0.6811564029158519 1.0 1.0 15 O75844 1 +Aplasia hypoplasia affecting the eye 0.2833599788514669 0.4095467921302296 0.6821384350947399 1.0 1.0 84 Q7LGA3,Q96ST3,P21912,Q15555,P18074,Q13363,O43924,P30153,O43505,P21964,P61978,O96028,O95721,P07437,O75312,P37268,Q9UHX1,O14936 18 +Abnormality of circulating enzyme level 0.2852026922519441 0.4053383749039817 0.6852288023099606 1.0 1.0 82 Q92734,Q14126,O14979,Q08J23,P43243,P53985,Q5JRX3,P22626,P50402,Q96BR5,O43505,Q9BQP7,P10253,P31483,O43772,Q13501,Q16836,P35573,P47985,P23786 20 +Rieger anomaly 0.5571169352442962 0.403715307257194 0.6864220819790905 1.0 1.0 4 O96028 1 +Abnormality of the nasal dorsum 0.3045111974797822 0.4025790742405871 0.6872579063196849 1.0 1.0 47 P16278,Q15022,P27635,Q13363,Q53EZ4,P61978,O96028,P10644,O95721,O75312,O75844,Q6PGP7,Q06124 13 +Dicarboxylic aciduria 0.3411460284087287 0.4025590725920933 0.687272623159632 1.0 1.0 20 P48735,Q9H3L0 2 +Absent facial hair 0.3916642298781467 0.4022027279133144 0.687534834785422 1.0 1.0 10 O75844 1 +Missing ribs 0.4025258712470333 0.4009283244802411 0.6884728954367199 1.0 1.0 9 Q06124 1 +Overweight 0.4386602946552091 0.4007546958388349 0.6886007368403886 1.0 1.0 6 Q9UKG1,P49748 2 +Bradycardia 0.402118144083685 0.3991444236127273 0.6897867910182256 1.0 1.0 9 O43772 1 +Abnormal respiratory system morphology 0.3109911950122279 0.3981622665488213 0.6905105783490071 1.0 1.0 270 Q92734,Q99567,Q15392,Q13363,P10644,P43243,Q6UN15,P27635,Q9Y487,P18074,Q16134,O75844,Q06330,Q92804,P29372,O00462,P49327,P09601,P16435,P54802,Q14108,P04062,Q06124,O75648,P07602,P52701,Q15165,Q9Y285,Q99496,Q96GM5,P28070,P53634,P15260,Q8N9N2,Q07864,P49748,P35637,O96028,P08236,P36543,P16278,P01889,P06280,P21266,P30154,Q969G3,Q5JTZ9,Q14739,P98175,P42858,Q8NFH4,O75718,P14174,P21964,P57740,Q53EZ4,P10253,O95721,Q9UHX1,P50995,Q6PGP7,Q9BYW2,Q01844,Q06787,Q02750,P17812,Q96PZ0,Q16637,Q13432,P04066,P07737,Q7LGA3,Q9NZ08,Q92990,P46109,O15344,Q9BW27,Q13501,P78318,Q9UJX6,Q12769,P13051 82 +Parkinsonism 0.3110392215885981 0.3966950720303751 0.691592334606481 1.0 1.0 27 P07602,P04062 2 +Typical absence seizure 0.3558206275534728 0.3955629928255043 0.6924274423264247 1.0 1.0 15 P61978,Q7L7X3 2 +Abnormality of the uterus 0.3013234168674879 0.3946862704991982 0.6930744364472439 1.0 1.0 49 O60566,P21912,P52701,Q07864,Q13363,P30153,O60216,P21964,Q15437,O96028,P10644,P57740,Q16740 13 +Abnormal joint morphology 0.3153183941113223 0.3935406953660505 0.6939201730543596 1.0 1.0 229 Q99567,O75718,P14174,Q15392,Q13363,Q8TD16,O60216,O75477,P21964,Q96AY3,O96028,P08236,P10644,P36543,Q03164,O75312,P57740,P16278,Q7LGA3,Q15022,P50402,P38435,P27635,Q9Y487,P18074,P01889,P06280,Q9NZ08,O75844,P37268,Q9UHX1,P46109,P10321,P21912,Q8N0X7,O15270,Q8IWS0,Q9Y619,Q14108,P42892,P04062,Q9BYW2,Q06124,Q14739,P07602,P42858,Q9UJX6,Q86XL3,Q02750,P28070,Q9UBS4,P23786 52 +Shallow orbits 0.4091725648747479 0.3928104908241101 0.694459455684898 1.0 1.0 8 O75844 1 +Spastic paraplegia 0.3083078109091628 0.392169157137788 0.6949332315705719 1.0 1.0 40 O75306,Q8N0X7,Q96CU9,P04062 4 +Steppage gait 0.3445925405374281 0.3911692411977266 0.6956721425455452 1.0 1.0 19 Q96BR5,O15270,P04792,P31483,Q13501 5 +Eeg with multifocal slow activity 0.4360771580405633 0.3911067291513644 0.6957183468731805 1.0 1.0 6 Q05639,P49588 2 +Hyperthyroidism 0.4000597215034369 0.3901684870656612 0.6964119623567135 1.0 1.0 9 P21964,Q06787,Q9BUK6 3 +Thoracic scoliosis 0.3771436278627492 0.389405002899197 0.6969765717539966 1.0 1.0 11 O75844,Q9UHX1 2 +Abnormal macroscopic urine appearance 0.3477080694905725 0.3892877181498442 0.6970633206841137 1.0 1.0 18 P23786,P57740,Q9BW27,Q8NFH4 4 +Wide mouth 0.2913254895700687 0.3889732249087503 0.6972959531868357 1.0 1.0 55 P16278,Q01105,Q7LGA3,Q969G3,P55795,Q4G0J3,Q02750,Q99496,Q96GM5,Q08J23,Q6PGP7,P42345 12 +Aplasia hypoplasia of the hallux 0.3471746164282393 0.3862105094623136 0.6993407710126913 1.0 1.0 18 Q7LGA3,P42858,Q13363,Q96PZ0,O96028,Q9UHX1 6 +Abnormal involuntary eye movements 0.3135515392107982 0.3857719852576439 0.6996655448412998 1.0 1.0 250 Q96CU9,Q15392,O60216,P35637,Q9NXN4,O96028,O75503,Q08J23,P36543,Q7LGA3,O00584,O43676,Q96IJ6,P01889,O43924,Q9H061,Q6P4Q7,Q8WXW3,P21912,Q15555,Q8IV08,Q15067,Q9H3L0,Q8IWS0,O43772,P03886,Q5JTZ9,P04062,Q9BYW2,Q96ST3,Q8N183,Q9BW83,Q13501,Q06124,P78318,Q06787,O14773,P07602,P42858,Q5KU26,Q9UJX6,P40818,Q02750,Q96D71,Q9Y6M9,Q96PZ0,O75306,Q6DKK2,P42356,O14936,P17900 51 +Hypoplasia of the brainstem 0.3267461128148753 0.3833567693180127 0.7014552524496356 1.0 1.0 22 O14936,P07437,O43505 3 +Frequent falls 0.3075916911664949 0.3824038767618419 0.7021618152578881 1.0 1.0 35 P07602,P04062 2 +Poor fine motor coordination 0.433640805269327 0.3820702781298917 0.7024092370699695 1.0 1.0 6 P42858 1 +Aplasia hypoplasia of the clavicles 0.3870886297170775 0.3814097872965686 0.7028991997137495 1.0 1.0 10 O75844 1 +Neoplasm of the liver 0.3090564254757463 0.3782200154899326 0.7052671577251148 1.0 1.0 31 P52701,P11717,Q969G3,Q10713,P49327,Q9UKG1,Q96GM5,P10644,Q6PGP7 9 +Abnormality of the tonsils 0.432299388755875 0.3771216789906537 0.7060831811084463 1.0 1.0 6 P31751 1 +Abnormal clavicle morphology 0.3478451986559682 0.374040999115968 0.7083738135338418 1.0 1.0 17 Q9Y619,O75844,Q14739 3 +Cafe au lait spot 0.3059572899606849 0.3723147417614453 0.7096585239875781 1.0 1.0 40 O75648,Q7LGA3,O60566,P21912,P52701,P42858,Q02750,Q15437,Q96PZ0,P10644,Q6PGP7,Q96ST3,Q9H1A4,P42345,Q06124 15 +Abnormal form of the vertebral bodies 0.2887855158039023 0.3719735285755904 0.7099125585867381 1.0 1.0 74 P16278,Q32P28,Q8WXW3,Q14739,O75874,P40818,Q13363,P04066,O60216,Q10713,Q9Y619,Q96AY3,O96028,P08236,P10644,P54802,P48735,Q9UHX1 18 +Abnormal fingertip morphology 0.3070713742523913 0.3718644586107848 0.7099937684195268 1.0 1.0 26 O75648,O14646,Q7LGA3,P42858,P50851,P55795,Q96PZ0,O75844 8 +Delayed gross motor development 0.2711332381146084 0.3714754771980142 0.7102834177308135 1.0 1.0 91 Q01105,Q03252,Q10713,P48449,P35637,Q96N66,Q03164,Q9UBB6,Q7LGA3,P11233,P27635,P10253,Q9Y296,P21912,Q9NVV4,P61978,O75648,P34897,P42858,Q6DN90,Q5KU26,Q9UJX6,P30153,Q96GM5,Q96D71,O94992,Q96PZ0,O14936 28 +Tinnitus 0.351191985861172 0.3711164755307166 0.7105507802064734 1.0 1.0 15 Q9NR28,P21912 2 +Enamel hypoplasia 0.3667857142857158 0.3708718480687724 0.7107329841814205 1.0 1.0 12 Q92889,Q8WUM0,P18074,O75369,P36776,P51648,O00443,P26639,Q15149,P19447,Q01968 11 +Abnormality of the forearm 0.3053146763744456 0.3700542211602064 0.7113420907999566 1.0 1.0 41 Q32P28,P98175,Q13363,Q02750,O60216,Q96AY3,O96028,P10644,Q06124 9 +Aplasia hypoplasia involving the nose 0.3071969894622755 0.3688416724143584 0.7122457411697718 1.0 1.0 27 Q5KU26,P55795,O94992,P61978,Q08J23,Q96ST3,O75844,P46109 8 +Abnormal leukocyte physiology 0.2957440236230542 0.3674045675995178 0.7133172650278095 1.0 1.0 51 P15260,P14174,P09601,P21964,P21266,P28070,Q15904,Q14108,Q6PGP7,P04062 10 +Embryonal neoplasm 0.3351668007132887 0.3660768112652525 0.7143077602545671 1.0 1.0 20 Q9UJX6,Q969G3,Q96GM5,Q6PGP7,Q9BYW2 5 +Disproportionate tall stature 0.317912905513583 0.3646197600760408 0.7153952624966615 1.0 1.0 23 O75648,Q7LGA3,P42858,Q13363,P16435,Q96PZ0,O96028,P36543,Q9Y296 9 +Joint subluxation 0.4288604997846995 0.3645238802616773 0.7154668447950667 1.0 1.0 6 P16278 1 +Thick nasal alae 0.3652747436144131 0.3636110301715978 0.7161484889355396 1.0 1.0 12 O75179 1 +Weakness of muscles of respiration 0.3064203495970404 0.3629464052393164 0.7166449205744103 1.0 1.0 33 P50402,Q15067,Q8TD16,Q9BQP7,P10253,P43243,P22626 7 +Abnormality of the pharynx 0.3052160962225462 0.36250292717891 0.7169762365005541 1.0 1.0 38 P16278,O15344,P29372,Q13432,P01889,Q969G3,P21964,P54802,P08236,P43243,P13051 11 +Heterotaxy 0.5430157967081892 0.361690183106106 0.7175835638474668 1.0 1.0 4 O96028 1 +Vertical supranuclear gaze palsy 0.3708650982910436 0.3598708768505834 0.7189436968380036 1.0 1.0 11 P61916,O15118 2 +Autism 0.3047194194010637 0.3584304264787187 0.7200212251299587 1.0 1.0 38 O76024,Q05639,P49588,P21912,Q06787,P27635,O60216,Q14353,P21964,Q15437,P10644,Q96ST3 12 +Squamous cell carcinoma 0.370295630040287 0.3572208134739247 0.7209265055605212 1.0 1.0 11 P53634,P18074,Q9H1A4,Q9H4L7 4 +Increased body weight 0.2685171850294463 0.3568945347068534 0.7211707612738225 1.0 1.0 92 P42345,Q10713,P38159,P21964,O60216,Q9UKG1,O75312,Q9C0B1,P50402,P51114,Q15555,Q969G3,Q8IWS0,Q12955,Q96ST3,Q9BYW2,Q9BW83,Q06787,P31751,P40818,Q9Y2R0 21 +Ventricular arrhythmia 0.3055893794077308 0.3565144031828061 0.7214553675994444 1.0 1.0 33 P50402,P21912,O43772,P03886,P10253,O75306,P42892,P23786 8 +Abnormality of coagulation 0.2972032825558789 0.3562348200612846 0.721664717465913 1.0 1.0 49 Q6UN15,O75874,Q16836,Q9Y487,Q02750,Q9Y619,P47985,P10644,P40855,P36543,P48735,Q00059,Q06124 13 +Abnormality of the ureter 0.2898118030734122 0.356207195614987 0.721685403588318 1.0 1.0 60 Q9BYW2,P21912,Q86XL3,O14936,O60216,P21964,Q53EZ4,P61978,O75844,Q9UHX1,P23786 11 +Cachexia 0.3443491975180253 0.3547432664187624 0.7227819343035438 1.0 1.0 17 P07602,P04062 2 +Colon cancer 0.3628571428571418 0.3520690576061349 0.7247864730738363 1.0 1.0 12 O60566,P52701,Q16658,P04637,Q15645,P39019,Q8WX93,P10644,P43246,O96017,O43684 11 +Speech apraxia 0.30971914015895 0.3508757752097425 0.7256815460663537 1.0 1.0 24 O75648,O14646,Q7LGA3,P42858,Q8N0X7,Q9Y619,Q96PZ0,Q9Y296 8 +Distal lower limb amyotrophy 0.3688081326644883 0.350321882292001 0.7260971448138813 1.0 1.0 11 Q8TD16,P04792 2 +Widow s peak 0.5388166646905592 0.3495172692553013 0.7267010083452852 1.0 1.0 4 O15344 1 +Aplasia hypoplasia of the ovary 0.3469648782664919 0.3491312976214273 0.7269907410510807 1.0 1.0 15 P57740,Q9BW83,Q06124 3 +Adrenal insufficiency 0.309289133480997 0.3479786223689244 0.727856238255741 1.0 1.0 24 Q96IJ6,Q969G3,O95470,P16435,P40855 5 +Overgrowth 0.4634966141578622 0.3470518785801605 0.7285523445226871 1.0 1.0 5 Q9BYW2,P61978 2 +Frontotemporal dementia 0.3678677745876996 0.3459780974238519 0.7293591751572848 1.0 1.0 11 P35637,P22626,P31483 3 +Abnormal circulating non proteinogenic amino acid concentration 0.4234990515669704 0.3451448116584942 0.729985506104724 1.0 1.0 6 Q9Y619,P03886 2 +Thoracic hypoplasia 0.3031951955755478 0.3444454243336711 0.7305113327013808 1.0 1.0 26 Q14739,Q96A33,O75718,P16435,P04062,Q9UHX1,P42345 7 +Skeletal muscle hypertrophy 0.302616948236474 0.3443937114700754 0.7305502174765715 1.0 1.0 40 P16278,P21912,P04066,Q15437,P10253,P61978,Q9C0B1 7 +Self injurious behavior 0.3025762554210038 0.3440557847480943 0.7308043338633319 1.0 1.0 40 Q01105,Q06787,P55795,Q4G0J3,Q10713,O14936,Q6IA86,Q7L7X3 8 +Mandibular prognathia 0.3031526146020672 0.3416780496559939 0.7325931928350582 1.0 1.0 34 P16278,Q15022,Q06787,Q9UJX6,P10644,Q9BYW2,Q9UHX1,Q06124 8 +Proptosis 0.3002565267262634 0.3409979357841978 0.733105135717131 1.0 1.0 44 Q32P28,O75718,Q969G3,P61978,O96028,O75844,Q06124 7 +Neoplasm of head and neck 0.3964944216958601 0.3408624929093702 0.7332071019700281 1.0 1.0 8 O96017,O60216,P21912,Q8N9N2 4 +Microdontia 0.3018205963315357 0.3400943442610273 0.733785480826981 1.0 1.0 25 Q9Y487,Q15555 2 +Oral aversion 0.4035994563580011 0.3399423228563729 0.7338999635297374 1.0 1.0 7 Q969G3 1 +Fetal ultrasound soft marker 0.3602198557458145 0.3395870413654241 0.73416753829688 1.0 1.0 12 P61978,Q13501,P40855,Q06124 4 +Preaxial foot polydactyly 0.5351187815609616 0.3389329802088547 0.7346602187583777 1.0 1.0 4 O96028 1 +Hallux valgus 0.3454045961519765 0.3363851488493111 0.736580447155663 1.0 1.0 14 P04062 1 +Calvarial hyperostosis 0.5340751792024758 0.3359692823969507 0.7368940305268605 1.0 1.0 4 P22626 1 +Hyperactivity 0.2902214113328049 0.3354401835051677 0.7372930599508551 1.0 1.0 134 Q9UJS0,Q10713,O60216,P21964,Q96N66,P10644,O75503,Q08J23,Q03164,Q9H1A4,Q9UBB6,Q7LGA3,P49588,P55795,Q14353,Q9UHX1,P46109,Q9Y296,Q05639,O00462,P00367,O75179,Q969G3,Q12955,P23378,P54802,Q96ST3,Q9BYW2,O75648,P34897,Q06787,P52701,P42858,Q6DN90,Q9UJX6,P30153,Q96GM5,Q96PZ0,Q9BVA1,O14936,Q16531,Q96C86,P42345 43 +Abnormal pulmonary thoracic imaging finding 0.3348298506370173 0.3339587028720456 0.7384107216373956 1.0 1.0 19 P01889,P15260,P04062 3 +Abnormality of the columella 0.3420666363508433 0.3314324281363954 0.7403178736232201 1.0 1.0 16 P36543 1 +Easy fatigability 0.3396899391532454 0.3294072851784034 0.7418478620159088 1.0 1.0 17 P61978,P21912 2 +Mild short stature 0.6062513626196588 0.3285664640073147 0.7424833997324096 1.0 1.0 3 Q14739 1 +Abnormality of the endometrium 0.3929356231279117 0.3266453406853927 0.7439361460466984 1.0 1.0 8 Q15437 1 +Widely spaced teeth 0.3011516831632477 0.325835700851692 0.7445486661008052 1.0 1.0 27 P16278,P08236,Q4G0J3,O60216 4 +Diffuse mesangial sclerosis 0.3408447879484937 0.3250450714002225 0.7451469601198863 1.0 1.0 16 Q9BW27,Q8NFH4,O95470,P57740,Q12769 5 +External ear malformation 0.3503119518084644 0.3246726475253209 0.74542883820556 1.0 1.0 13 Q15555 1 +Impaired temperature sensation 0.4172592448377717 0.3230096696939572 0.7466879189235902 1.0 1.0 6 O15270 1 +Pseudoepiphyses 0.455932344870418 0.3228735132421406 0.746791036269093 1.0 1.0 5 O96028 1 +Pseudoepiphyses of hand bones 0.455932344870418 0.3228735132421406 0.746791036269093 1.0 1.0 5 O96028 1 +Generalized tonic seizure 0.3359394580282002 0.3227337942190436 0.7468968564212382 1.0 1.0 18 O14936,Q7L7X3 2 +Abnormality of exocrine pancreas physiology 0.3402941586194087 0.3221767473474334 0.7473187990362635 1.0 1.0 16 P14174,P21266,P09601,Q15904,Q9UHX1 5 +Excessive daytime somnolence 0.3495681096178128 0.3211173804099715 0.7481214395771214 1.0 1.0 13 Q969G3,Q99496,P42858,Q99567 4 +Malrotation of small bowel 0.603187428947759 0.3207798654849897 0.7483772187241757 1.0 1.0 3 O96028 1 +Abnormality of abdominal situs 0.603187428947759 0.3207798654849897 0.7483772187241757 1.0 1.0 3 O96028 1 +Ectopia pupillae 0.603187428947759 0.3207798654849897 0.7483772187241757 1.0 1.0 3 O96028 1 +Craniofacial asymmetry 0.603187428947759 0.3207798654849897 0.7483772187241757 1.0 1.0 3 O96028 1 +Hypoplastic pubic rami 0.603187428947759 0.3207798654849897 0.7483772187241757 1.0 1.0 3 O96028 1 +Rib segmentation abnormalities 0.603187428947759 0.3207798654849897 0.7483772187241757 1.0 1.0 3 O96028 1 +Congenital localized absence of skin 0.5718861209964342 0.3188555876826156 0.7498360236396526 1.0 1.0 2 Q15149 1 +Aplasia cutis congenita over the scalp vertex 0.5718861209964342 0.3188555876826156 0.7498360236396526 1.0 1.0 2 Q15149 1 +Oculogyric crisis 0.3555245489225004 0.3176559940828222 0.7507458950942334 1.0 1.0 12 Q7L7X3 1 +Impairment in personality functioning 0.3066170619904623 0.3174234570373079 0.7509223106729785 1.0 1.0 188 Q96CU9,O60216,P21964,P35637,Q9NXN4,Q96N66,O75503,Q08J23,P07737,Q03164,Q7LGA3,P01889,P55795,P06280,P46109,Q92804,P50897,P21912,P50995,Q969G3,Q8N0X7,Q4G0J3,P03886,Q5JTZ9,P23378,P04062,Q9BYW2,Q8N183,Q13501,Q06787,P07602,P42858,Q15165,Q9UJX6,Q96PZ0,O75306,Q6DKK2,Q96C86,P17900 39 +Abnormality of temperature regulation 0.2654423166056793 0.3158121248986937 0.7521451144372144 1.0 1.0 92 P15260,P14174,P10644,P57740,Q6UN15,P01889,Q9NZ08,P06280,P10253,Q9BW27,O43772,P03886,P61978,Q14739,P07602,O14936,Q8NFH4,Q02750,P28070,P47985,Q12769,P23786 22 +Pancreatic cysts 0.5266552158639626 0.3152006860706426 0.7526092846865533 1.0 1.0 4 Q9UBS4 1 +Abnormality of the peritoneum 0.3343241926710826 0.3138299652213607 0.7536501843504073 1.0 1.0 18 Q01844,P57740,Q9BW27,Q8NFH4 4 +Abnormality of the upper arm 0.336385675804942 0.3117178141075076 0.7552549883653137 1.0 1.0 17 P50402,P53597,O14979,P16435,O00116 5 +Abnormality of the chin 0.2852752782482052 0.3104278683818775 0.7562356042732763 1.0 1.0 69 P16278,O14646,Q7LGA3,Q15022,Q9BYW2,P11233,Q06787,Q9UJX6,Q08J23,P10644,P36543,O75844,Q07954,Q9UHX1,P46109,P42345,Q06124 17 +Short femur 0.4517428311970337 0.3097520381680892 0.7567495268484001 1.0 1.0 5 O00116,Q9UHX1 2 +Abnormal hypothalamus physiology 0.3884878587043622 0.3091169002593183 0.7572326037904458 1.0 1.0 8 Q969G3,Q99496 2 +Choanal stenosis 0.5238617180597835 0.3075221561660722 0.7584459613579289 1.0 1.0 4 Q53EZ4 1 +Abnormal muscle glycogen content 0.4510108750975942 0.3074798565714102 0.7584781530277018 1.0 1.0 5 O75648,P13807 2 +Dyskinesia 0.2864496518887095 0.3071130976162334 0.7587572886916214 1.0 1.0 53 Q01105,Q05639,P49588,O43819,P52701,Q6DN90,P03886,O75306,Q96N66,Q08J23,P04062,O14936,Q9UBX3,Q96C86,Q9UBB6,Q7L7X3 16 +Apnea 0.2851536797793531 0.3067432829903865 0.7590387818249287 1.0 1.0 68 Q96CU9,P07602,O43924,O43772,P04062,P51114 6 +Glomerulonephritis 0.3330145023228651 0.3066541070648018 0.759106664965981 1.0 1.0 18 Q9BW27,Q03252,Q8NFH4,P49327,P57740,Q12769 6 +Congenital sensorineural hearing impairment 0.3945309506274399 0.3055877990265722 0.7599185113296048 1.0 1.0 7 O76024,Q16740 2 +Abnormal growth hormone level 0.3028957744867154 0.3055045547722747 0.7599819014819134 1.0 1.0 24 Q969G3,Q99496,P10644,Q96ST3,Q03164 5 +Hamartoma of the eye 0.369744000290655 0.3052296872887178 0.7601912233715047 1.0 1.0 10 Q15437 1 +Abnormal conus terminalis morphology 0.4120378108364237 0.3048493159735123 0.7604809193473787 1.0 1.0 6 O96028 1 +Decreased facial expression 0.2972314738077754 0.303103514076843 0.7618109762049694 1.0 1.0 26 Q06787,P38606,Q9Y3I1,Q969X5,Q96RR1,Q9BUK6,Q9Y263,P04062,Q05086 9 +Abnormality of the pulmonary vasculature 0.2972985751037822 0.3011823539952037 0.7632754449481793 1.0 1.0 35 P42858,O75718,Q15392,Q96PZ0,Q6PGP7,Q06124 6 +Stenosis of the external auditory canal 0.3932536417154039 0.3008361623308489 0.7635394314364317 1.0 1.0 7 Q13363,O96028 2 +Meningitis 0.4488438331554445 0.3007887232722511 0.763575607963856 1.0 1.0 5 P01889,Q9NZ08,P49327 3 +Hand muscle weakness 0.3684125380851091 0.2995690674549972 0.764505881704177 1.0 1.0 10 Q8TD16,P31483 2 +Diabetes insipidus 0.3445901423617346 0.2975950529135872 0.7660122508010396 1.0 1.0 13 P01889 1 +Insulin resistant diabetes mellitus 0.3854224062129452 0.2971966747175487 0.7663163604387693 1.0 1.0 8 O75844,P31751 2 +Sleep disturbance 0.286871369257814 0.2955325853045372 0.7675870638571523 1.0 1.0 133 Q01105,Q9UJS0,Q99567,Q9Y3I1,O60216,Q8NHS3,O75503,Q08J23,Q96N66,Q7LGA3,O95831,P51114,Q9UHX1,O76024,P50897,Q969G3,Q8N0X7,Q4G0J3,Q12955,P61978,P54802,P04062,Q96ST3,Q7L7X3,O75648,Q06787,P42858,Q6DN90,P40818,Q99496,Q96PZ0,O14936,Q16531,Q96C86 34 +Short 1st metacarpal 0.4470965443533913 0.2954331513865138 0.767663011703108 1.0 1.0 5 Q6KC79,O60216,Q14683,Q9NVI1 4 +Carious teeth 0.2967240313585906 0.2939837479145327 0.7687703222066813 1.0 1.0 38 P16278,Q15555,Q9Y487,P21964,P36543 5 +High pitched voice 0.3503416270492963 0.2939008092479164 0.7688336997120597 1.0 1.0 12 O75844 1 +Abnormality of the external nose 0.3074555523460489 0.2931510122963715 0.7694067264246183 1.0 1.0 203 Q15392,Q13363,Q10713,P38159,P21964,O60216,O96028,P10644,P40855,P36543,Q03164,Q08J23,O75312,Q9C0B1,P16278,Q7LGA3,Q15022,P11233,P27635,Q9Y487,O95831,P18074,O43924,P55795,Q53EZ4,O95721,O75844,Q9UHX1,P46109,P10586,O15344,O75179,Q8WXW3,Q15555,Q969G3,P61978,Q6PGP7,P42892,P04062,Q96ST3,Q06124,Q06787,P98175,Q5KU26,P30153,Q02750,P35573,O94992,P23786,O14936 50 +Lower limb hypertonia 0.3768446469626668 0.2927579881518979 0.7697071425259738 1.0 1.0 9 P21912 1 +Increased blood pressure 0.2838584095454806 0.291317790678854 0.7708082822345381 1.0 1.0 67 Q06787,P21912,P01889,P40818,P06280,Q10713,Q9BW83,P21964,P03886,Q9UBS4,P10644,P42892,P04062,Q9NQH7,O75844,Q06330 16 +Spina bifida 0.2972679816215504 0.2910900774678244 0.770982428538034 1.0 1.0 30 P21964,Q08J23,Q96ST3,Q9UHX1,Q06124 5 +Oligohydramnios 0.2972671104939269 0.291083853836127 0.7709871882942276 1.0 1.0 30 Q9Y285,Q9UHX1,Q53EZ4,P51114,P23786 5 +Basal ganglia calcification 0.3833935625713716 0.2893815027533019 0.7722894484269025 1.0 1.0 8 P03886,O00429 2 +Abnormality of long bone morphology 0.2942520585044152 0.2875501664068657 0.7736910957365943 1.0 1.0 152 O75874,O75718,Q13363,Q13126,Q96AY3,O96028,P08236,P10644,P40855,Q08J23,O75312,P22626,P16278,Q7LGA3,Q15022,P38435,Q9Y487,O75844,P48735,Q9UHX1,P37268,P46109,Q8N0X7,Q4G0J3,Q9Y619,O00116,Q13501,Q06124,Q32P28,Q14739,P98175,P42858,Q02750,Q96PZ0,O14936 35 +Intellectual disability progressive 0.3545975191939936 0.286213893820699 0.7747143029441006 1.0 1.0 11 Q15067,P18074,O95721 3 +Abnormality of central nervous system electrophysiology 0.2852159596007468 0.285717788642166 0.775094279047329 1.0 1.0 131 Q96A33,Q13363,P48449,P21964,O96028,Q8NHS3,O75503,P40855,Q08J23,Q96N66,P57740,Q9BQE5,Q9UBB6,P49588,P27635,P18074,Q06330,Q9UBX3,Q05639,P00367,P50897,P38606,O75179,Q15067,Q8IWS0,P03886,Q5JTZ9,Q14108,Q9Y263,Q13501,P07602,Q6DN90,Q9UJX6,Q02750,O43292,P42356,O14936,Q96C86 38 +Aggressive behavior 0.2820126009917705 0.2856589020300428 0.775139384967173 1.0 1.0 72 Q10713,O75503,Q03164,P55795,O00462,Q969G3,Q12955,P23378,P54802,Q96ST3,Q9BYW2,Q13501,Q6IA86,P34897,Q06787,P42858,Q6DN90,Q9UJX6,Q96GM5,Q96PZ0,Q6DKK2 21 +Adducted thumb 0.3053450151066257 0.2838988279891685 0.7764879146898078 1.0 1.0 23 Q86XL3,P42892 2 +Turricephaly 0.3817597810623061 0.2831318838000421 0.7770757413917484 1.0 1.0 8 P16435,P21964,P07237 3 +Recurrent fever 0.353647166905817 0.2820498575089333 0.7779052807528573 1.0 1.0 11 P28070 1 +Bladder neoplasm 0.4426627378255346 0.2820042170664962 0.777940276734385 1.0 1.0 5 P63167,O60566 2 +Sparse eyelashes 0.3336061501296773 0.2819925913832241 0.7779491910976262 1.0 1.0 15 O75844 1 +Anhidrosis 0.4048974193247646 0.2805750853800877 0.7790363276930612 1.0 1.0 6 O15270 1 +Vertebral segmentation defect 0.2937294461300622 0.2793390419302427 0.779984647126817 1.0 1.0 26 Q13363,O60216,Q9Y619,P61978,O96028,Q9UHX1 6 +Short phalanx of the thumb 0.404490377761931 0.2792114436538218 0.7800825619724923 1.0 1.0 6 Q9NVI1,O60216,Q6KC79,Q9UQE7,Q14683 5 +Fused cervical vertebrae 0.404490377761931 0.2792114436538215 0.7800825619724925 1.0 1.0 6 O75369,Q9NVI1,Q9UHX1,Q9Y2W2,Q9Y5S9 5 +Abnormal palmar dermatoglyphics 0.2835093965806119 0.2791978566766842 0.7800929883907213 1.0 1.0 53 P98175,Q99567,Q9Y487,Q13363,Q9UHX1,Q02750,O60216,Q53EZ4,P61978,O96028,P40855,Q96ST3,P57740,P42345 14 +Vitreous hemorrhage 0.5860154098729722 0.2787681440783887 0.7804227630241578 1.0 1.0 3 Q99496 1 +Renal hypoplasia aplasia 0.2764600457838627 0.2782832206647825 0.7807949555745068 1.0 1.0 80 O75179,Q15392,Q86XL3,O43924,O60216,P21964,Q53EZ4,O75306,Q6PGP7,O75312,Q9BYW2,Q9UHX1,Q06124 13 +Absent fingernail 0.3803841643338064 0.2779005201760522 0.7810887245812046 1.0 1.0 8 O14936,P46109 2 +Emg abnormality 0.2826267131030005 0.2770240128022332 0.7817616678837649 1.0 1.0 65 Q92734,P50402,O14773,Q8TB36,Q16637,P07602,Q14126,O15270,P04792,P31483,P51114,Q13501,P22626 13 +Paraplegia paraparesis 0.2816517370031581 0.2744794206171092 0.7837162165177167 1.0 1.0 70 P21912,Q96CU9,Q8N0X7,P35637,O75306,Q6DKK2,P04062 7 +Hyperostosis 0.3395008479676001 0.2740520179426625 0.7840446467387041 1.0 1.0 13 P22626,Q02750,P10644 3 +Highly arched eyebrow 0.2801259642099077 0.272772796711904 0.7850278719208057 1.0 1.0 56 O75648,Q7LGA3,P34897,Q8WXW3,P42858,Q5KU26,Q13363,O43924,O60216,Q10713,O94992,Q96PZ0,O96028,Q9UHX1,P46109 15 +Brain imaging abnormality 0.2935138884794783 0.2691603980443094 0.7878062537923842 1.0 1.0 37 O43819,P21912,O00429,P07602,P53597,Q9UJX6,Q969G3,Q99496,Q14353,Q969X5,P03886,O75306,Q96ST3,Q9BYW2,Q13501,Q93009 16 +Abnormal oral physiology 0.2824256935660865 0.2690075338270291 0.7879238851462804 1.0 1.0 53 Q14739,Q15165,P50995,P01889,P55795,Q8N0X7,P35637,P10644,P07737,P43243,Q9BVA1,P42356,Q13501,Q92804 14 +Pseudoepiphyses of the metacarpals 0.5093433968359414 0.2689058679419404 0.7880021212788173 1.0 1.0 4 O96028 1 +Recurrent respiratory infections 0.2693553832450819 0.267907922832347 0.7887701950252164 1.0 1.0 104 P16278,P07602,Q16637,Q13432,Q9Y487,P01889,Q969G3,P14174,P09601,P21266,P10253,P54802,O96028,P08236,P04062 15 +Secondary microcephaly 0.2816361955435829 0.2678196759564265 0.7888381245953018 1.0 1.0 63 Q96CU9,P50897,Q9Y487,P55795,O95721,P00374,P36543,O14936 8 +Muscle weakness 0.3068634158180521 0.267535141112801 0.7890571611792749 1.0 1.0 247 Q92734,Q96CU9,Q8TB36,Q96B26,Q16637,Q70HW3,O14979,Q8TD16,Q10713,Q13126,P35637,P10644,P40855,P43243,P06865,P07737,P22626,Q6UN15,P50402,O43676,Q96BR5,P01889,O95831,O43505,Q9BQP7,P10253,O95721,P31483,P51114,Q9UHX1,Q92804,P21912,P50995,Q15067,Q969G3,Q8N0X7,O15270,O43772,P03886,Q5JTZ9,P61978,Q8N183,Q13501,Q6IA86,Q06124,Q14739,Q06787,P07602,P42858,Q15165,Q5KU26,P35573,P04792,Q9Y6M9,O94992,O75306,P47985,P00374,P23786,Q6DKK2,P42356,O14936,P17900 63 +Movement abnormality of the tongue 0.5792696253526511 0.2630472941880211 0.7925141267863329 1.0 1.0 3 P10253 1 +Tooth malposition 0.2742719000035486 0.2627419057503954 0.7927495150627306 1.0 1.0 81 P16278,Q14739,Q8N0X7,P61978,P08236,P36543,O75844,Q06124 8 +Localized skin lesion 0.3030693411166827 0.2617538447704676 0.7935112251739653 1.0 1.0 189 O75874,Q15392,Q13363,Q13126,P35637,P21964,O96028,Q96AY3,P10644,Q08J23,Q03164,Q7LGA3,Q15022,P38435,P27635,P01889,Q9NZ08,P06280,Q92990,O75844,P48735,Q9UHX1,P21912,Q15555,Q92542,O15270,Q9Y619,P61978,Q6PGP7,P04062,Q96ST3,Q06124,Q14739,Q06787,P07602,P42858,P40818,Q02750,Q15437,Q06136,Q96PZ0,Q07954,P42345 43 +Abnormal cornea morphology 0.2806555641338102 0.2569817508434671 0.7971928608184071 1.0 1.0 126 P04066,O60216,P21964,O96028,P08236,P16278,Q7LGA3,P01889,Q9NZ08,P06280,O43505,O75844,P10619,Q15555,P04062,Q9BYW2,Q14739,P42858,Q06136,Q96PZ0,P07437 21 +Hepatomegaly 0.2889524139213019 0.2521507119679633 0.8009245734821888 1.0 1.0 145 Q96CU9,P08236,P16278,O43676,P21266,O43772,P09601,Q9Y619,O15118,P54802,Q14108,P04062,Q06124,Q14739,P07602,P31751,P28070,Q15904,O75306,P00374,Q9Y6M9 21 +Abnormality of the antitragus 0.545195729537358 0.25152532013652 0.8014079886390784 1.0 1.0 2 Q92643 1 +Prominent antitragus 0.545195729537358 0.25152532013652 0.8014079886390784 1.0 1.0 2 Q92643 1 +Abnormality of the helix 0.2912626319842916 0.2491204193832612 0.8032676349008256 1.0 1.0 33 Q02750,P21964,O75844,P23786,Q06124 5 +Abnormality of the calvaria 0.3060824618960464 0.2468813998590655 0.805000011605407 1.0 1.0 222 O14646,Q01105,O75718,Q15392,Q13363,P04066,Q10713,O60216,P21964,Q96AY3,O96028,P10644,P40855,P36543,Q03164,Q08J23,P22626,Q9C0B1,P16278,P27635,Q9Y487,O95831,P18074,O43924,Q16134,O95721,O75844,Q06330,O15344,O75179,Q8WXW3,Q15067,Q8IWS0,Q9Y619,P61978,P54802,Q6PGP7,P04062,Q9BYW2,Q06124,Q32P28,Q14739,P98175,Q06787,Q9UJX6,P30153,Q02750,P07437,P42356,O14936,P42345 51 +Peritonitis 0.3266195729411494 0.2465796347748128 0.8052335670543609 1.0 1.0 14 P57740,Q9BW27,Q8NFH4,Q12769 4 +Minimal change glomerulonephritis 0.3266195729411494 0.2465796347748128 0.8052335670543609 1.0 1.0 14 P57740,Q9BW27,Q8NFH4,Q12769 4 +Retinal atrophy 0.2885014829274492 0.244623325201585 0.80674810178247 1.0 1.0 26 Q7LGA3,P42858,P51648,Q96PZ0,P04062,P04439 6 +Abnormal dermatoglyphics 0.2793288408992708 0.2446105523427793 0.8067579926557187 1.0 1.0 63 P98175,Q99567,Q9Y487,Q13363,Q9UHX1,Q02750,O60216,Q53EZ4,P61978,O96028,P40855,Q96ST3,P57740,P42345,Q06124 15 +Abnormal nervous system electrophysiology 0.2953609165601556 0.2445520860035194 0.8068032674213748 1.0 1.0 164 Q92734,Q8TB36,Q13363,P48449,P21964,O96028,Q8NHS3,O75503,P40855,P43243,Q08J23,Q96N66,P57740,Q9BQE5,P27635,P18074,O95721,Q9UBX3,O75179,P50897,Q15067,Q8IWS0,O15270,Q9Y619,Q5JTZ9,P03886,Q14108,Q13501,O14773,P07602,Q9UJX6,Q02750,P04792,P42356,O14936,Q96C86 36 +Clonus 0.2882940006649612 0.243265203663119 0.8077999582804702 1.0 1.0 26 Q9Y619,P35637,Q8N0X7,P07602 4 +Abnormal b cell morphology 0.3771595344980344 0.2429510450341342 0.8080433217072724 1.0 1.0 7 P17812,P49327,Q13432 3 +Decreased circulating androgen concentration 0.3445153961473081 0.2428917786030138 0.8080892346154349 1.0 1.0 11 P16435,Q969G3,Q99496 3 +Central apnea 0.3703923726630459 0.2407759336370475 0.8097287831310165 1.0 1.0 8 P07602,Q10713 2 +Abnormality of the wrist 0.2925976289532339 0.2396737015212008 0.8105832239286777 1.0 1.0 24 P16278,O75844 2 +Abnormal renal pelvis morphology 0.2860760337302442 0.2390136985524624 0.8110949606414808 1.0 1.0 47 O76024,P98175,O75718,Q9UJX6,Q8N0X7,Q02750,O43505,P16435,P61978,Q08J23,P40855,Q9BYW2,P23786,Q16531 14 +Impaired vibratory sensation 0.2976905069024567 0.2369752759551246 0.8126759709337867 1.0 1.0 23 Q9Y619,O14773,Q8N0X7 3 +Cubitus valgus 0.3312125496709811 0.2368740045915964 0.8127545374562548 1.0 1.0 13 P57740,Q06124 2 +Abnormal renal tubule morphology 0.312053299494598 0.2329446124439891 0.8158044154629127 1.0 1.0 20 P06280,P03886,O75306,P57740,P23786 5 +Brisk reflexes 0.3165712287262586 0.2329393187529906 0.8158085261632055 1.0 1.0 19 P35637 1 +Limited elbow movement 0.2887230779306878 0.2313189498645451 0.817067026003375 1.0 1.0 30 Q7LGA3,P50402,Q96AY3,P23786,Q06124 5 +Hypoplasia of the radius 0.3672564081439753 0.2294531894226058 0.8185166994953457 1.0 1.0 8 P98175 1 +Restrictive cardiomyopathy 0.5352313167259698 0.2287037855374796 0.8190991523343805 1.0 1.0 2 Q969N2 1 +Back pain 0.315627314159764 0.227955593941752 0.8196807625500504 1.0 1.0 19 P01889,Q969G3 2 +Abnormality of the testis size 0.2873069911396865 0.2273800732979707 0.8201282137187746 1.0 1.0 28 Q06787,P27635,Q8IWS0,P38159,O43505,O75312 6 +Developmental regression 0.2697052895185767 0.2262293898389748 0.8210230132975662 1.0 1.0 110 P16278,O14773,P07602,P21912,P42858,Q96IJ6,P01889,P55795,P06280,O75306,O75503,O14936 12 +Nephritis 0.3009871647673744 0.2254949158910151 0.8215942800660971 1.0 1.0 22 Q9BW27,Q03252,Q8NFH4,P49327,Q9UBS4,P57740,Q12769 7 +Chorea 0.2767066916003527 0.2252865411871905 0.8217563691484386 1.0 1.0 71 Q01105,P35637,Q96N66,Q08J23,Q96IX5,Q9UBB6,P49588,P18074,Q14353,Q14671,Q9BWD1,Q9UN37,Q05639,P03886,Q6IA86,Q7L7X3,P07602,P42858,Q6DN90,O75306,O14936,Q96C86,P17900 23 +Personality changes 0.3208195321947327 0.2251356918403651 0.8218737155501077 1.0 1.0 16 P03886,P04062,P42858,P31483 4 +Microphallus 0.4916037471330925 0.2248199701985278 0.822119329765856 1.0 1.0 4 Q96ST3 1 +Kinetic tremor 0.2877288081938696 0.2245382555705149 0.82233850309926 1.0 1.0 30 Q06787,P07602,Q9Y287,Q9Y3I1,P18074,Q14108 6 +Low alkaline phosphatase 0.561545542869473 0.2239465694808938 0.8227988786375215 1.0 1.0 3 Q96S52 1 +Sudden loss of visual acuity 0.5320284697508806 0.2216448266511566 0.8245903836650266 1.0 1.0 2 O00170 1 +Retinal fold 0.5320284697508804 0.2216448266511563 0.8245903836650268 1.0 1.0 2 P52732 1 +Epigastric pain 0.5320284697508801 0.2216448266511561 0.824590383665027 1.0 1.0 2 Q9NWH9 1 +Splanchnic vein thrombosis 0.5320284697508801 0.2216448266511561 0.824590383665027 1.0 1.0 2 Q9NWH9 1 +Portal vein thrombosis 0.5320284697508801 0.2216448266511561 0.824590383665027 1.0 1.0 2 Q9NWH9 1 +Sloping forehead 0.2864793421534962 0.2197934319703983 0.8260320350923644 1.0 1.0 35 P98175,Q86XL3,Q08J23,P57740,O14936 5 +Spasticity 0.3016317905942675 0.2190039358300047 0.8266469818409536 1.0 1.0 266 Q01105,Q92734,Q96CU9,Q96B26,Q9Y3I1,Q15392,Q8TD16,P04066,Q10713,O75477,P35637,Q9NXN4,Q96N66,O75503,P40855,P43243,P36543,Q08J23,P07737,P16278,P61916,Q15022,O00584,Q9Y287,Q9Y487,P18074,O43505,P51648,Q14671,Q9UBX3,Q92804,P50897,P21912,P50995,Q8N0X7,Q12955,Q9Y619,Q5JTZ9,O15118,P11117,P03886,P04062,Q8N183,Q13501,Q6IA86,Q7L7X3,P07602,P42858,Q15165,Q5KU26,Q9UJX6,P40818,Q86XL3,Q96D71,O94992,O75306,Q6DKK2,P42356,O14936,Q96C86,P17900 61 +Paraplegia 0.2851303381921474 0.2189437888290994 0.8266938353287498 1.0 1.0 45 O75306,Q8N0X7,Q96CU9,P04062 4 +Progressive hearing impairment 0.3270885461387786 0.2189431856031497 0.826694305234601 1.0 1.0 13 O76024,O60443,P03886 3 +Left ventricular hypertrophy 0.2945221246355248 0.2181041109524503 0.827347994432093 1.0 1.0 23 P13807,P10253,P21912,P06280 4 +Excessive salivation 0.2831313170958354 0.2162359776852137 0.8288038107320328 1.0 1.0 25 Q9BVA1,P01889,Q8N0X7,P55795 4 +Narrow palate 0.2866767150017892 0.2155992151038012 0.8293001676692948 1.0 1.0 32 P18074,Q02750,Q9Y619,P61978,P23786,Q96ST3,P46109,Q06124 8 +Abnormal testis morphology 0.3010295424127807 0.2150822084947931 0.8297032248677247 1.0 1.0 195 Q99567,Q13363,P38159,O60216,P48449,P21964,O96028,P10644,P40855,P36543,Q08J23,O75312,Q9C0B1,Q7LGA3,Q15022,P46977,P27635,Q9Y487,P18074,O43924,O95470,P01889,O43505,Q9NZ08,P37268,P51114,Q9UBX3,O76024,P29372,O15344,Q15555,Q969G3,Q8IWS0,P49327,Q9Y619,P61978,Q96ST3,Q9BYW2,Q9BW83,Q06124,P78318,Q01844,Q06787,P98175,P42858,Q5KU26,Q9UJX6,Q86XL3,Q02750,O94992,Q06136,Q96PZ0,P07437,P42345 54 +Abnormality of the pubic bone 0.3842277478714506 0.2142532501696587 0.8303495724328815 1.0 1.0 6 O96028 1 +Epistaxis 0.3259756360633632 0.2141716640099599 0.8304131922361964 1.0 1.0 13 Q6UN15,P01889,P10644,P04062 4 +Coxa vara 0.3473400871904439 0.2140247105353117 0.8305277874073991 1.0 1.0 10 Q9Y487,Q96AY3,O75718 3 +Abnormal choroid plexus morphology 0.3834640057020603 0.2119221644479378 0.8321677585765135 1.0 1.0 6 Q12824,P07954,O43175,P53634,O96017 5 +Abnormality of adrenal physiology 0.2856420489029923 0.2104320236722253 0.8333305008827945 1.0 1.0 30 Q96IJ6,Q969G3,O95470,P16435,P10644,P40855 6 +Intellectual disability moderate 0.2756341155702547 0.2096780827878665 0.8339189326781546 1.0 1.0 62 Q01105,P38159,Q10713,Q96N66,Q08J23,Q9UBB6,Q9UHX1,Q05639,Q969G3,Q12955,P61978,Q9BYW2,Q7L7X3,P34897,Q06787,Q6DN90,Q9UJX6,Q96GM5,O14936,Q96C86 20 +Gait disturbance 0.2991739765967697 0.2056909550063023 0.8370323243487823 1.0 1.0 275 Q92734,Q96CU9,Q8TB36,Q9Y3I1,Q13363,Q8TD16,Q10713,O75477,P35637,Q96AY3,Q9NXN4,Q96N66,O75503,P43243,Q03164,Q5JRX3,P22626,P16278,Q7LGA3,P50402,Q96IJ6,P27635,P18074,O95831,O43924,P01889,P55795,Q96BR5,Q9NZ08,P31483,O75844,O14949,Q8WXW3,P21912,Q8IV08,Q9NVV4,Q9H3L0,Q969G3,Q8N0X7,P49327,O15270,Q9Y619,Q15067,O15118,P61978,Q14108,P03886,P04062,Q13501,O75648,P34897,Q06787,O00429,P52701,P07602,O14773,Q6DN90,P98175,P42858,P40818,P30153,Q99496,P04792,Q96D71,Q96PZ0,Q9BVA1,O14936,Q96C86,P42345 69 +Aplasia hypoplasia involving the pelvis 0.3174486153522529 0.2056576666466456 0.8370583287411835 1.0 1.0 14 P15260 1 +Abnormal thrombosis 0.2923011638063553 0.2050792896105046 0.8375101770374522 1.0 1.0 23 Q6UN15,O75874,P01889,P40818,Q9NZ08,P10644,P48735 7 +Abnormal lung development 0.2847484656012501 0.2049380543654318 0.8376205230804792 1.0 1.0 42 Q14739,P98175,P21964,Q53EZ4,Q5JTZ9,O96028,O75844 7 +Erectile dysfunction 0.3449127202843435 0.2046959604788143 0.8378096766559815 1.0 1.0 10 Q06787,Q99496,Q969G3 3 +Impotence 0.3449127202843435 0.2046959604788143 0.8378096766559815 1.0 1.0 10 Q06787,Q99496,Q969G3 3 +Confusion 0.3133477140553358 0.2040350649030115 0.8383260974093827 1.0 1.0 18 Q16836,P18074,P01889,Q9NZ08,P49327,Q9Y619 6 +Broad alveolar ridges 0.5227758007117339 0.2020185080626957 0.8399022551401962 1.0 1.0 2 P21281 1 +Poor speech 0.2723734172630029 0.201843274222105 0.8400392497961782 1.0 1.0 76 Q01105,Q96CU9,O00584,Q9Y487,P61978,P08236,P36543,Q7L7X3 8 +Abnormal blistering of the skin 0.3162854916935492 0.2009665410003678 0.8407247367040573 1.0 1.0 15 P01889,Q9NZ08,P49327,Q06136 4 +Mildly elevated creatine kinase 0.3012868659767682 0.1997784241857651 0.8416538761667831 1.0 1.0 21 O75648,Q92734,P43243,Q16836,Q96RR1,Q9BUK6,P31483,Q13501 8 +Abnormality of the musculature of the lower limbs 0.3010951500362067 0.1987378127107348 0.8424678437012498 1.0 1.0 21 Q96IJ6,P50402,O14979 3 +Tube feeding 0.2731275550271231 0.1972662060348869 0.8436192233794895 1.0 1.0 58 O75648,Q01105,Q92734,O00429,P07602,Q6DN90,P30153,P35637,P61978,Q96N66,Q08J23,P37268,Q9UHX1,Q9H1A4,Q96C86,Q7L7X3 16 +Abnormal hand morphology 0.2595297452608065 0.197208639471673 0.843664270057719 1.0 1.0 97 Q13363,Q8TD16,O60216,O96028,P36543,Q03164,Q15022,P38435,P27635,O95831,O75844,Q9UHX1,Q06330,P46109,P21912,Q969G3,Q8N0X7,Q8IWS0,Q96ST3,Q9BYW2,Q9UJX6,P42356,O14936,P42345 24 +Congenital malformation of the right heart 0.3632477274884818 0.1961232080455296 0.8445137316025668 1.0 1.0 7 P01889 1 +Oligomenorrhea 0.3781508618171327 0.195953754213695 0.8446463629710261 1.0 1.0 6 P31751 1 +Renal tubular atrophy 0.4790414156984572 0.1957863612947933 0.8447773855888134 1.0 1.0 4 P57740 1 +Pterygium 0.3325292345644085 0.1940035730823481 0.8461730841436395 1.0 1.0 11 Q96AY3,Q99567 2 +Numerous pigmented freckles 0.4778633337393035 0.1931598652806243 0.8468337696261945 1.0 1.0 4 P18074 1 +Defective dna repair after ultraviolet radiation damage 0.4778633337393035 0.1931598652806243 0.8468337696261945 1.0 1.0 4 P18074 1 +Mitochondrial inheritance 0.4777717387493693 0.1929563579477273 0.8469931470249141 1.0 1.0 4 P03886 1 +Radioulnar synostosis 0.3110677260746104 0.1928171121561281 0.8471022014048963 1.0 1.0 18 Q13363,O96028,O60216,Q06124 4 +Large fleshy ears 0.5181494661921606 0.1926357579802972 0.847244238576965 1.0 1.0 2 P21281 1 +Tetraparesis 0.2832442867035319 0.1919782335686364 0.8477592553818929 1.0 1.0 32 P21912,P07602,P35637,Q9UBX3,P17900 5 +Hepatic fibrosis 0.2800895170610115 0.1908421365618227 0.8486492751332622 1.0 1.0 26 Q9UJS0,P35573,Q10713,Q9BW83,Q15904,Q6PGP7,P04062,Q06330 8 +Hip dislocation 0.271985045592496 0.1906886580425864 0.8487695252097924 1.0 1.0 57 Q9Y487,Q8TD16,O96028,P36543,O75844 5 +Spinal muscular atrophy 0.3197785222344643 0.1881424059105501 0.8507650195134557 1.0 1.0 13 Q8TD16,Q96B26 2 +Abnormal renal cortex morphology 0.2747885166232136 0.187069790390532 0.8516059137837582 1.0 1.0 52 Q9BW27,P21912,P01889,Q03252,Q9NZ08,P06280,O95470,P49327,Q16134,P03886,Q8NFH4,Q14108,Q6PGP7,Q9NQH7,P57740,Q12769 16 +Increased connective tissue 0.3603620229169473 0.186811234812047 0.8518086378838354 1.0 1.0 7 P31751 1 +Germ cell neoplasia 0.3541061335222907 0.1837983532957844 0.8541716480111119 1.0 1.0 8 Q9BYW2 1 +Increased circulating gonadotropin level 0.3392924106472351 0.1835461401446872 0.854369519043197 1.0 1.0 10 P57740,Q06787 2 +Abnormality of the leydig cells 0.5131672597864743 0.1828543587457709 0.8549122954550421 1.0 1.0 2 Q9NNW7 1 +Hypernatriuria 0.5131672597864743 0.1828543587457709 0.8549122954550421 1.0 1.0 2 Q9NNW7 1 +Abnormal urine sodium concentration 0.5131672597864743 0.1828543587457709 0.8549122954550421 1.0 1.0 2 Q9NNW7 1 +Leydig cell neoplasia 0.5131672597864743 0.1828543587457709 0.8549122954550421 1.0 1.0 2 Q9NNW7 1 +Abnormal response to insulin tolerance test 0.5131672597864743 0.1828543587457709 0.8549122954550421 1.0 1.0 2 Q9NNW7 1 +Testicular adrenal rest tumor 0.5131672597864743 0.1828543587457709 0.8549122954550421 1.0 1.0 2 Q9NNW7 1 +Sensory neuropathy 0.2810374343039336 0.1828010899356655 0.8549540933777569 1.0 1.0 29 Q92734,Q8IV08,Q15067,O95831,O15270,P03886,P22626 7 +Severe muscular hypotonia 0.2802976692891135 0.1818756015678223 0.8556803522612613 1.0 1.0 28 Q01105,Q7L7X3,O43505 3 +Abnormal pons morphology 0.3020338355569905 0.1798409771841032 0.8572774129079959 1.0 1.0 20 Q9BVA1,Q9UJX6,P30153,O14936 4 +Cerebral cortical atrophy 0.2546700605945331 0.177134919983003 0.8594024134261415 1.0 1.0 92 Q7LGA3,Q06787,P42858,Q96B26,Q5KU26,Q9H3L0,O43924,Q8TD16,Q02750,O60216,Q9Y619,P03886,Q96PZ0,O75503,Q13501,P04062,O14936 17 +Acute lymphoblastic leukemia 0.3273862210368429 0.1739666498820452 0.8618916720691434 1.0 1.0 11 Q9BYW2,Q9UJX6,Q08J23 3 +Abnormal glomerular mesangium morphology 0.3085834610797083 0.1734064755253535 0.8623319354805827 1.0 1.0 17 Q9BW27,Q8NFH4,O95470,P57740,Q12769 5 +Calvarial skull defect 0.3505654750660622 0.1720327454414242 0.8634117856161927 1.0 1.0 8 Q13363,Q14739,O96028 3 +Rib fusion 0.3555766407081455 0.1716868093991022 0.8636837564032924 1.0 1.0 7 O96028 1 +Chronic constipation 0.2757088047386824 0.1705094545042424 0.8646094996202287 1.0 1.0 25 Q7LGA3,P55795,P04062 3 +Constriction of peripheral visual field 0.3074075180030911 0.1680200659819333 0.8665674931193914 1.0 1.0 17 Q9H061 1 +Optic disc coloboma 0.4003327064390047 0.1665140326971091 0.867752440836709 1.0 1.0 5 P78318,Q10713 2 +Nocturnal seizures 0.5042704626334493 0.166224257061105 0.8679804706207912 1.0 1.0 2 Q01082 1 +Morphological abnormality of the middle ear 0.4001350121962628 0.1660327641455923 0.8681311659510389 1.0 1.0 5 Q9BYW2 1 +Abnormality of facial soft tissue 0.2612709151332548 0.1640894501207529 0.8696607268279126 1.0 1.0 104 Q9Y3I1,Q03252,O43707,P40855,Q9BUF5,Q9H1A4,P57740,Q9BQP7,P10253,Q9BUK6,O75844,Q9UHX1,O43819,Q9BW27,P21912,Q969G3,P16435,Q9Y263,P04062,Q13501,P34897,O00429,P52701,P30153,Q8NFH4,Q99496,P28070,Q15437,P42356,Q12769 30 +Cryptorchidism 0.2898543339776533 0.1637050050949464 0.8699633772126851 1.0 1.0 165 Q99567,Q13363,O60216,P48449,P21964,O96028,P10644,P40855,P36543,Q08J23,Q9C0B1,Q7LGA3,Q15022,P46977,P27635,Q9Y487,P18074,O43924,O43505,P37268,P51114,O15344,Q15555,Q969G3,Q8IWS0,Q9Y619,P61978,Q96ST3,Q9BYW2,Q9BW83,Q06124,P78318,Q06787,P98175,P42858,Q5KU26,Q9UJX6,Q86XL3,Q02750,O94992,Q96PZ0,P07437,P42345 43 +Abnormality of the gastric mucosa 0.307310285381977 0.1629225290026031 0.8705794322453608 1.0 1.0 14 O76024,Q14739,P49327,Q6PGP7,P04062 5 +Pseudobulbar signs 0.3243466399162835 0.1624039182875077 0.8709877854545751 1.0 1.0 11 P17900 1 +Pulmonic stenosis 0.2771349560069624 0.1619980339481815 0.871307402102641 1.0 1.0 28 O75306,Q02750,Q6PGP7,Q06124 4 +Genu valgum 0.278240819782962 0.1618343202241483 0.8714363256457298 1.0 1.0 30 P16278,Q8N0X7,Q02750,Q9Y619,P08236,O75312 6 +Overlapping fingers 0.3523219987027334 0.1616315009469775 0.8715960493063291 1.0 1.0 7 Q8TD16 1 +Hypoglycemic coma 0.3415084361455165 0.1608365656192728 0.8722221249357107 1.0 1.0 9 Q16134,Q16836,P31751 3 +Chronic diarrhea 0.3064084937450155 0.1595452279493779 0.8732393278834594 1.0 1.0 16 P02786,Q96A33,P50851,P18074,Q15904,Q08J23 6 +Abnormality of endocrine pancreas physiology 0.4618615302684906 0.1591629258071494 0.8735405123807327 1.0 1.0 4 P53985 1 +Thyroid adenoma 0.4615831733977497 0.1585995715429922 0.8739843663821598 1.0 1.0 4 P10644 1 +Hip dysplasia 0.2778164872714136 0.1567757062030375 0.8754216197066635 1.0 1.0 44 O75648,Q7LGA3,P42858,Q13363,Q8TD16,P30153,O60216,P61978,O96028,Q96PZ0,P36543,Q9UHX1,Q16531 13 +Gonadal dysgenesis 0.3318353438685907 0.1564912085850461 0.8756458484048351 1.0 1.0 10 P18074,P57740,Q96RR1 3 +Rhabdomyosarcoma 0.3642195295794688 0.1562180963531513 0.8758611130270246 1.0 1.0 6 O60566,P04637,Q15645,P21359,O96017 5 +Neoplasm of striated muscle 0.3642195295794688 0.1562180963531513 0.8758611130270246 1.0 1.0 6 O60566,P04637,Q15645,P21359,O96017 5 +Ophthalmoparesis 0.2705421533093305 0.1562114891666961 0.8758663208662312 1.0 1.0 66 P21912,Q96CU9,Q15555,P01889,O75306,P04062 6 +Abnormality of immune serum protein physiology 0.3500891265597126 0.1548432090496129 0.8769449260989011 1.0 1.0 7 Q5TBB1,P09884,P42224,P49327,P55265,O75792 6 +Metopic synostosis 0.5249231370755422 0.1537918911766899 0.8777738276753753 1.0 1.0 3 P61978 1 +Abnormality of epiphysis morphology 0.2740514888571404 0.1531822519456453 0.8782545533812336 1.0 1.0 49 P16278,Q7LGA3,Q14739,P38435,Q13363,O95831,Q9Y619,O00116,O96028,P08236,P10644,P40855,Q06124 13 +Generalized hypopigmentation 0.3444545733340581 0.1522772116410115 0.8789682977753064 1.0 1.0 8 Q6PGP7 1 +Triangular face 0.2774044581295493 0.1501220628424091 0.8806683136045663 1.0 1.0 37 O75179,Q02750,Q96AY3,P04062,P36543,Q06124 6 +Impaired visuospatial constructive cognition 0.3375860145926096 0.1476270763584121 0.8826370853856673 1.0 1.0 9 P03886,P42858 2 +Aplasia hypoplasia of the femur 0.3033678749723607 0.1470589642846824 0.8830854794095864 1.0 1.0 14 P15260,O95831,Q96HY6,O00116,Q9UHX1 5 +Holoprosencephaly 0.3290506780870903 0.1466932649703877 0.8833741348691575 1.0 1.0 10 Q9P2D1,O60566,O94979,Q15645,Q8N3U4,A5YKK6,Q14683,O43684,Q9UBM7 9 +Facial diplegia 0.3288824482848081 0.1461067739010411 0.8838370990053377 1.0 1.0 10 P34897,O43819,P42356 3 +Ulnar claw 0.5203156979243717 0.1460139933956988 0.8839103416900242 1.0 1.0 3 P04792 1 +Esodeviation 0.2761448977828147 0.1442996038176748 0.8852638911415736 1.0 1.0 33 Q5KU26,P18074,O43924,O94992,P04062,Q9UHX1,Q16531 7 +Dilated cardiomyopathy 0.2757434568290922 0.1421297174635172 0.8869775453089794 1.0 1.0 32 P16278,O43819,Q16836,Q14126,P49748,Q9BQP7,Q96RR1,P03886,O75306,P57740,P23786,P42166 12 +Hypoplastic female external genitalia 0.3020343584780703 0.1417922986728273 0.8872440673751272 1.0 1.0 14 Q9Y619,O60216 2 +Abnormality of the lymph nodes 0.2748406749034947 0.1403020235826708 0.888421365552559 1.0 1.0 30 Q6UN15,Q01844,P15260,P14174,P01889,Q9NZ08,P49327,P28070,P10644,P13051 10 +Neoplasm of the stomach 0.3008018434884201 0.1385407184996721 0.8898130911579902 1.0 1.0 17 P21912,P52701,O60566,P11802,Q99496,P10644 6 +Nyctalopia 0.2732202284461172 0.1379920252619622 0.8902467201711 1.0 1.0 28 Q15555,Q9Y287,Q13432,Q10713,P40855,O75312,Q6P4Q7 7 +Abnormal forearm bone morphology 0.2973413020110657 0.1367134752007258 0.891257277877227 1.0 1.0 19 Q32P28 1 +Abnormality of the diencephalon 0.2728184342870262 0.1355666767075315 0.8921638503306157 1.0 1.0 28 O75306,O43924 2 +Abdominal obesity 0.3859225895668179 0.132950396198681 0.8942326102313518 1.0 1.0 5 O75312 1 +Aplasia hypoplasia of the pubic bone 0.4480495936045489 0.1323865341007105 0.8946785651590654 1.0 1.0 4 O96028 1 +Abnormal ilium morphology 0.2998471457139539 0.1313722453034419 0.8954808433923931 1.0 1.0 15 P16278 1 +Upper limb amyotrophy 0.2991951324331627 0.1307488648969998 0.8959739755141436 1.0 1.0 14 Q13501,Q8TB36,P04792,P31483 4 +Hypoplastic aortic arch 0.4465935374397062 0.1297046501809911 0.8968001033384088 1.0 1.0 4 Q9UHX1 1 +Degeneration of the lateral corticospinal tracts 0.3540164733060408 0.1291666657895291 0.897225772057195 1.0 1.0 6 P35637 1 +Duodenal atresia 0.3359486447931538 0.1259798505434114 0.899747874422463 1.0 1.0 8 Q9P2D1,Q9Y2W2,O60566,P49454,Q15645,Q7LBC6,O43684 7 +Absent hypoplastic paranasal sinuses 0.5066075616064323 0.1242753946293762 0.9010972284975344 1.0 1.0 3 P04066 1 +Hemivertebrae 0.3137955286678961 0.12394779621868 0.9013566087910484 1.0 1.0 11 Q9Y619,Q9UHX1,O60216 3 +Periorbital fullness 0.2961961878902001 0.12354505131343 0.9016755017275098 1.0 1.0 18 Q7LGA3,O14646,O75179,P38159,P07437 5 +Abnormality of male internal genitalia 0.3345221112696199 0.1217100994865819 0.9031286144733824 1.0 1.0 8 Q6ZRS2,P04637,Q8IWS0,P49959,O96017,Q8IY37,P13051 7 +Inability to walk 0.2635805142719539 0.1208587803178756 0.903802891314136 1.0 1.0 78 P21912,Q96CU9,P42858,O15270,P35637,P61978,O75503 7 +Prolonged bleeding following procedure 0.475800711743768 0.1201997069884596 0.9043249498829156 1.0 1.0 2 P49257 1 +Renal cyst 0.263039950605693 0.1197583705755994 0.9046745599991874 1.0 1.0 55 O60216,Q10713,Q9UKG1,P21964,O43505,Q16134,Q53EZ4,Q6PGP7,P40855,Q9UBS4,P23786,Q9UHX1,Q9BW83 13 +Gliosis 0.2735061268848273 0.1193931804808966 0.9049638638388788 1.0 1.0 40 Q92734,P42858,Q9Y3I1,Q10713,P35637,Q9NXN4,O75306,P04062,Q13501 9 +Prominent forehead 0.2660020346044035 0.1192973664533157 0.905039769866745 1.0 1.0 72 Q15392,P04066,Q10713,O75312,Q7LGA3,Q15022,P11233,Q9UHX1,O15344,P29372,Q4G0J3,Q6PGP7,Q9BYW2,O75648,Q14739,Q06787,P42858,Q9UJX6,O14936,Q96PZ0,P23786,P42345 22 +Abnormal serum interferon level 0.3499643620812473 0.1189220521867006 0.905337110620286 1.0 1.0 6 Q5TBB1,P09884,P42224,P55265,O75792 5 +Abnormal heart valve physiology 0.2648646756868159 0.1183823190350374 0.905764734626208 1.0 1.0 75 P16278,P01889,Q9NZ08,P06280,O60216,Q02750,Q15904,O75306,Q6PGP7,P04062,P36543,O75844,Q9UHX1,Q06124 14 +Delayed fine motor development 0.3324733087011257 0.1156497995709713 0.9079300933189052 1.0 1.0 8 Q5KU26,Q9UJX6,O94992 3 +Abnormal anterior horn cell morphology 0.3486094881832167 0.1155609779944826 0.908000490691617 1.0 1.0 6 Q16637 1 +Enlarged cisterna magna 0.3060519701069108 0.1140235919933275 0.9092190917022652 1.0 1.0 12 Q9BYW2,Q9UJX6,Q10713 3 +Arterial stenosis 0.2943576808926952 0.112475746541778 0.9104461991577766 1.0 1.0 14 P01889 1 +Abnormal renal corticomedullary differentiation 0.4697508896797119 0.1118104956014864 0.9109736654238024 1.0 1.0 2 O60231 1 +Reduced renal corticomedullary differentiation 0.4697508896797119 0.1118104956014864 0.9109736654238024 1.0 1.0 2 O60231 1 +Abnormal brain positron emission tomography 0.3469099560798755 0.1113908056022062 0.9113064507544184 1.0 1.0 6 Q969G3,Q13501 2 +Abnormal uvea morphology 0.2572865555227052 0.1113795209575491 0.9113153989172568 1.0 1.0 85 P78318,Q7LGA3,Q8WXW3,P21912,Q96IJ6,P14174,P01889,Q13363,Q10713,O43505,Q9Y619,O96028,P10644,Q96ST3,Q9UHX1,O14936,P04439 17 +Abnormal mean corpuscular hemoglobin concentration 0.4974986510038786 0.1109885896850021 0.9116253949392092 1.0 1.0 3 P18074 1 +Low set nipples 0.4974986510038786 0.1109885896850021 0.9116253949392092 1.0 1.0 3 P18074 1 +Tiger tail banding 0.4974986510038786 0.1109885896850021 0.9116253949392092 1.0 1.0 3 P18074 1 +Increased mean corpuscular hemoglobin concentration 0.4974986510038786 0.1109885896850021 0.9116253949392092 1.0 1.0 3 P18074 1 +Concave nail 0.4974986510038786 0.1109885896850021 0.9116253949392092 1.0 1.0 3 P18074 1 +Ankle flexion contracture 0.2937157118862566 0.110102977459061 0.9123277068456406 1.0 1.0 14 Q9UJX6,P27635,Q969X5,Q96AY3,Q9BYW2 5 +Functional motor deficit 0.2681606461401812 0.1085397190886886 0.9135675753263814 1.0 1.0 124 Q92734,Q8TD16,O75477,P35637,Q9NXN4,P10644,P43243,P13807,P49588,P27635,Q9BQP7,Q9BUK6,P31483,Q9H2D1,Q05639,O43819,P21912,P38606,Q9NVV4,Q15067,Q969G3,Q8N0X7,P03886,P61978,P04062,Q13501,O00429,P07602,O14773,P42858,Q9Y285,Q99496,P04792,O43292,P23786,Q9Y2R0 36 +Abnormal duodenum morphology 0.298906607216538 0.1077143328474302 0.91422229969803 1.0 1.0 13 O60566,P98175,P49454,O60216 4 +Broad long bones 0.2693589604684178 0.106711915169036 0.915017529648323 1.0 1.0 30 P42858,Q96PZ0,Q08J23,Q9UHX1,O14936 5 +Macroorchidism 0.3733247868320957 0.1061835013315467 0.915436760965989 1.0 1.0 5 P38159 1 +Aplasia hypoplasia involving the sinuses 0.4326272971346999 0.105356503370552 0.916092929194491 1.0 1.0 4 P04066 1 +Poikiloderma 0.3721675640941846 0.1038474102545495 0.917290441892238 1.0 1.0 5 P18074,Q9H1A4 2 +Muscle fibrillation 0.2927046501149399 0.103597156548107 0.9174890442687338 1.0 1.0 15 Q92734,P51114,Q16637,P04792 4 +Abnormal shape of the frontal region 0.2522600231822861 0.1024907692374006 0.9183671393484676 1.0 1.0 89 P16278,O14646,O15344,Q14739,Q06787,Q9Y487,Q15392,Q15067,O43924,Q02750,P04066,Q9Y619,O96028,Q6PGP7,P42345 15 +Striae distensae 0.3232251159472041 0.1019984803269763 0.9187578813174148 1.0 1.0 9 P04637,Q15334,P40818,O00170,P17612,P10644,Q96T58,Q13620 8 +Abnormal parotid gland morphology 0.4619217081850512 0.1016575747995193 0.9190284780287103 1.0 1.0 2 P16615 1 +Gastrostomy tube feeding in infancy 0.2668133042070149 0.1002063778445134 0.9201804827155416 1.0 1.0 28 P37268,Q01105,P35637,Q7L7X3 4 +Functional abnormality of the middle ear 0.2561875124443709 0.09929457354959 0.920904386806461 1.0 1.0 85 P78318,Q7LGA3,Q9BYW2,P21912,Q15555,P42858,Q9UJX6,P01889,O95831,Q13363,O43924,O60216,P16435,P21964,P61978,O96028,Q96PZ0,O75844 18 +Vitiligo 0.3417234354069104 0.0989826611291024 0.9211520369046352 1.0 1.0 6 P03886,P49327 2 +Peripheral arterial stenosis 0.459430604982208 0.098591011081202 0.9214630073658494 1.0 1.0 2 P31153 1 +Mixed hypo and hyperpigmentation of the skin 0.4594306049822077 0.0985910110812017 0.9214630073658496 1.0 1.0 2 P55265 1 +Atrial flutter 0.4594306049822063 0.0985910110812 0.921463007365851 1.0 1.0 2 O75694 1 +Juvenile aseptic necrosis 0.3692318901450859 0.0980144463164275 0.9219208221015744 1.0 1.0 5 Q9Y619 1 +Dark urine 0.4587188612099617 0.0977292131357625 0.922147317860416 1.0 1.0 2 P36551 1 +Aplasia hypoplasia of the ear 0.2670995198082826 0.0975795709139906 0.9222661471251938 1.0 1.0 49 Q15555,Q9Y619,P61978,O96028,P04062 5 +Hypochromia 0.4583629893238419 0.0973006982496466 0.9224876015102356 1.0 1.0 2 Q86SX6 1 +Elevated hemoglobin a1c 0.4266145858617574 0.0956429159644597 0.9238041794039936 1.0 1.0 4 Q9UKG1 1 +Specific learning disability 0.2627731550787216 0.0955301853095206 0.9238937154812006 1.0 1.0 60 Q9BVA1,Q06787,P42858,Q9UJX6,Q8N0X7,Q10713,O43505,P21964,P35637,Q9Y619,P03886,Q9BYW2,P42356,Q13501,P22626,P42345 16 +Hypogonadism 0.256715049308558 0.0950771330718215 0.9242535609474944 1.0 1.0 84 Q07864,P48449,P10644,Q9H1A4,P18074,O95470,Q9BQP7,Q9BZH6,O95721,O75844,Q9UN37,O76024,Q15555,Q969G3,Q8IWS0,Q96RR1,P03886,Q9BW83,Q16740,Q06124,Q06787,O00429,Q02750,Q99496 24 +Cortical cataract 0.4544483985765121 0.09269130976321 0.9261488010928768 1.0 1.0 2 Q99797 1 +Panhypogammaglobulinemia 0.3662883819109194 0.0923005760545385 0.9264592306999258 1.0 1.0 5 Q6PGP7 1 +Self mutilation 0.3238357560053325 0.0910486686572844 0.927453919624322 1.0 1.0 8 Q4G0J3 1 +Absent brainstem auditory responses 0.4813100747596982 0.0896304854393453 0.9285808580219924 1.0 1.0 3 Q92889,Q13724 2 +Moderately reduced visual acuity 0.4813100747596945 0.0896304854393408 0.928580858021996 1.0 1.0 3 P63000,O00429 2 +Neoplasm of the eye 0.2889378272567611 0.0890787064161941 0.9290193599280688 1.0 1.0 17 Q15437,P18074,P21912,P52701 4 +Focal onset seizure 0.2613774863516288 0.0878749649388974 0.929976054697329 1.0 1.0 76 Q01105,Q96N66,Q08J23,O75503,Q9UBB6,P27635,Q14353,Q9UPT5,Q9UBX3,P21912,Q969G3,P03886,Q9BYW2,Q7L7X3,O00429,P07602,Q6DN90,Q9UJX6,Q99496,Q9BVA1,P42356,O14936,Q96C86,P42345 24 +Optic disc hypoplasia 0.4788931653197206 0.0866859000319005 0.9309211843689384 1.0 1.0 3 O95721 1 +Increased muscle glycogen content 0.4786442923197997 0.0863862476534974 0.931159378843912 1.0 1.0 3 O75648 1 +Hypoplastic fingernail 0.2870035433240297 0.0860427796712117 0.9314324100422772 1.0 1.0 14 Q969G3 1 +Progressive leukoencephalopathy 0.4777655001066453 0.0853334463305801 0.9319963021711106 1.0 1.0 3 Q5JTZ9 1 +External ophthalmoplegia 0.2875093115323664 0.0843893088835031 0.9327469072401844 1.0 1.0 15 P03886,P21912,Q9BQP7 3 +Abnormality of fundus pigmentation 0.4177490590568793 0.0821622692531496 0.9345176767388624 1.0 1.0 4 Q9Y619 1 +Deviation of the hallux 0.2625650397297752 0.081873900563947 0.934746989076264 1.0 1.0 27 P57740,Q96PZ0,P42858,P04062 4 +Contractures involving the joints of the feet 0.277773052055052 0.0818060450059561 0.9348009489696412 1.0 1.0 21 P50402,Q8TD16,Q08J23 3 +Irritability 0.2607539959581882 0.0816976430984464 0.9348871526308916 1.0 1.0 76 Q9BW27,P21912,P50897,Q06787,P07602,Q5KU26,P42858,P01889,Q15067,Q9NZ08,Q8NFH4,O43772,O94992,P23378,P37268,P57740,Q13501 17 +Biconcave vertebral bodies 0.3340195314332546 0.0814462804373254 0.9350870448693456 1.0 1.0 6 Q96AY3 1 +Abnormal epiglottis morphology 0.4741901032395814 0.0811348890301659 0.935334679706082 1.0 1.0 3 Q15427,Q13510 2 +Aortic aneurysm 0.2632191018306918 0.0811149548291869 0.9353505326452496 1.0 1.0 51 Q7LGA3,Q9BYW2,Q06787,P42858,P01889,P61978,Q96PZ0,Q9UBS4,O75844,P46109 10 +Abnormal preputium morphology 0.3234382378215393 0.0810917810382259 0.9353689619437736 1.0 1.0 7 Q9BYW2 1 +Abnormal circulating hormone concentration 0.2543699941773875 0.0795549370675931 0.9365912365723246 1.0 1.0 85 O75844,P21912,Q15555,Q06787,P31751,Q16836,Q969G3,P57740,Q03164,P53985 10 +Decreased activity of mitochondrial complex iii 0.4145299145299174 0.0775142772170569 0.9382144338694148 1.0 1.0 4 P53597,Q5JPH6,P43897 3 +Abnormal circulating free fatty acid concentration 0.4139325205281372 0.0766661226128718 0.9388891554304016 1.0 1.0 4 Q16836 1 +Neoplasm of the larynx 0.413722258333318 0.076368671621036 0.9391257932218008 1.0 1.0 4 O96017,P52701 2 +Trichorrhexis nodosa 0.4678459702474734 0.0740169505877203 0.9409968976381552 1.0 1.0 3 Q6PGP7 1 +Broad finger 0.2637628663940281 0.0739311361107304 0.9410651806009792 1.0 1.0 30 P42858,Q96PZ0,Q08J23,Q9UHX1,O14936 5 +Distal upper limb amyotrophy 0.2987411000182692 0.0738585022748524 0.941122976007304 1.0 1.0 11 Q13501,Q8TB36,P31483 3 +Synostosis of joints 0.2619166338051522 0.0726546490236482 0.942080937956724 1.0 1.0 28 Q13363,O60216,P16435,O96028,Q9UHX1,Q06124 6 +Foot dorsiflexor weakness 0.2633231666469257 0.0714226981539879 0.9430613452237908 1.0 1.0 30 Q14739,Q96BR5,O15270,P04792,P31483,Q13501 6 +Dyspnea 0.2494832775798689 0.0710588678340801 0.9433509040923996 1.0 1.0 89 Q92734,P35637,P10644,P07737,P43243,Q6UN15,P01889,O95831,P06280,Q9BQP7,P10253,O75844,Q9UHX1,Q92804,P50995,Q9Y619,P03886,P04062,Q13501,P07602,Q15165,O75306,P23786 23 +Neoplasm of the male external genitalia 0.3125085907413631 0.0708800910086194 0.9434931885896952 1.0 1.0 9 Q01844 1 +Hypogonadotropic hypogonadism 0.2578418204338987 0.0701207665400489 0.9440975380752636 1.0 1.0 25 Q06124 1 +Sparse or absent eyelashes 0.2706068546003196 0.0672047031191678 0.9464187410440528 1.0 1.0 22 P48449,O75844,Q02750 3 +Dysmenorrhea 0.4595941616233561 0.0653825640838522 0.9478694062178524 1.0 1.0 3 P52926,O00170 2 +Aplasia hypoplasia of the phalanges of the toes 0.4595941616233501 0.0653825640838463 0.947869406217857 1.0 1.0 3 Q9ULC3,P21281 2 +Deviation of the thumb 0.280848988037936 0.0652070136275142 0.9480091769487032 1.0 1.0 14 O60216,Q96ST3 2 +Micropenis 0.2564836473647078 0.0640386231755561 0.9489394730602378 1.0 1.0 55 Q07864,Q03252,Q10713,P48449,O75312,O60566,P46977,P18074,O95470,O43505,Q9BZH6,P38606,Q8IWS0,P16435,Q9Y619,P42892,Q96ST3,Q06124,O14936 19 +Generalized dystonia 0.4241992882562148 0.0632086406508436 0.9496003642961202 1.0 1.0 2 P42704 1 +Limb muscle weakness 0.2599034340395735 0.063030398208942 0.9497422981690992 1.0 1.0 73 Q92734,P50402,Q14739,Q16637,Q96BR5,Q15067,Q969G3,Q8N0X7,O15270,P04792,Q13126,P31483,Q13501 13 +Broad thumb 0.2562078501122692 0.0616875138427734 0.9508116835419156 1.0 1.0 25 Q7LGA3,Q15022,P42858,Q96PZ0,Q08J23,Q9UHX1 6 +Abnormal eyelash morphology 0.2601113988632512 0.0587023987226285 0.9531891487305966 1.0 1.0 67 O75844,Q5KU26,Q969G3,Q02750,Q99496,O60216,P49327,P48449,Q9Y619,Q96GM5,O94992,Q03164,Q07954,Q9UHX1,Q16531 15 +Cerebellar cortical atrophy 0.4522935884627929 0.0583171389112224 0.9534960158709012 1.0 1.0 3 O75312 1 +Abnormal toenail morphology 0.2645141537217397 0.0574673298546109 0.9541729300828492 1.0 1.0 42 Q15022,Q14739,Q969G3,P23786,Q08J23,O75844,Q06330,P46109 8 +Lacticaciduria 0.398855784729927 0.0567368950496751 0.9547547833395011 1.0 1.0 4 P03886,P53597 2 +Puberty and gonadal disorders 0.2761663662380633 0.056685676561882 0.9547955841162364 1.0 1.0 150 Q9UJS0,O75874,Q13363,O60216,P48449,O96028,P10644,Q15800,P57740,Q7LGA3,P27635,P18074,O95470,P06280,Q9BQP7,O95721,O75844,P48735,O76024,Q15555,Q969G3,Q8IWS0,P16435,P03886,Q14108,P04062,Q9BW83,Q16740,Q06124,O75648,Q06787,O00429,P42858,Q02750,Q99496,Q96PZ0,O14936 37 +Abnormality of the proximal phalanx of the thumb 0.4124555160142392 0.0544608325962804 0.9565680133139828 1.0 1.0 2 Q9ULC3 1 +Synostosis involving digits 0.4124555160142331 0.054460832596276 0.9565680133139864 1.0 1.0 2 Q9H1A4 1 +Laryngeal cleft 0.4106761565836272 0.0532550740027369 0.9575286751250248 1.0 1.0 2 Q01082 1 +Absent toenail 0.3114961163985078 0.0526089138664379 0.9580435145696702 1.0 1.0 7 Q14739 1 +Impaired tandem gait 0.2781969508226521 0.052133168837738 0.95842258398101 1.0 1.0 15 Q96PZ0,Q06787,P42858 3 +Color vision defect 0.2787589519714806 0.0512713476035594 0.959109299365545 1.0 1.0 16 Q9H061,Q6P4Q7 2 +Autistic behavior 0.2823013878371594 0.0501075486627295 0.960036684333587 1.0 1.0 168 Q01105,Q96CU9,O60216,P48449,P21964,Q96N66,O75503,Q08J23,Q7LGA3,P11233,O43676,P55795,Q9UHX1,O75179,P21912,Q15067,Q969G3,Q12955,P03886,Q96ST3,Q9BYW2,Q8N183,Q13501,Q7L7X3,Q06787,P42858,Q5KU26,Q9UJX6,O14936,O94992,Q15437,Q96PZ0,O75306,Q9Y6M9,Q96C86,P42345 36 +Dysesthesia 0.3414968777148544 0.0495392533871272 0.9604895559072064 1.0 1.0 5 O15270 1 +Bell shaped thorax 0.4046263345195728 0.0493795286407519 0.9606168420352736 1.0 1.0 2 Q96HY6 1 +Abnormality of complement system 0.4417942328230724 0.0490678098602112 0.9608652565038482 1.0 1.0 3 P02545,Q03252 2 +Hypergalactosemia 0.4417942328230693 0.0490678098602089 0.96086525650385 1.0 1.0 3 Q9UJS0,Q96C23 2 +Large foramen magnum 0.4039145907473353 0.0489458214875143 0.9609624723327675 1.0 1.0 2 Q9ULC3 1 +Neoplasm of the peripheral nervous system 0.2776952989430308 0.0476096757843195 0.9620273206150692 1.0 1.0 16 Q07954,Q969G3,P21912,P10644 4 +Pulmonary artery stenosis 0.2855492381331707 0.0474105943977866 0.9621859854082656 1.0 1.0 12 Q06124 1 +Periorbital edema 0.2532590284616679 0.0468058227901753 0.96266798820634 1.0 1.0 25 P57740,Q9BW27,Q8NFH4,P28070 4 +Hypertrichosis 0.2449320991773316 0.0463577656155677 0.9630250984548274 1.0 1.0 91 P16278,Q96CU9,Q969G3,O75306,P54802,Q08J23,Q03164 7 +Peripheral cyanosis 0.3063480741797455 0.046085576109245 0.9632420423908834 1.0 1.0 8 Q5TBB1,O95163,Q9Y3Z3,P04066,P55265,O75792,Q9UHD8 7 +Expressive language delay 0.3063442670048849 0.0460765094960445 0.9632492688249694 1.0 1.0 8 P21912 1 +Abnormality of the auditory canal 0.2761524121731094 0.0452051149556688 0.9639438172750026 1.0 1.0 19 Q9Y619,Q13363,O96028,O60216 4 +Hypothermia 0.3027516419775233 0.0448227411405113 0.9642485984982032 1.0 1.0 9 O43772 1 +Ulnar deviation of the hand or of fingers of the hand 0.2962395579311131 0.0447617752555947 0.96429719346288 1.0 1.0 10 Q14739 1 +Thick lower lip vermilion 0.2621399626074228 0.0443257343768188 0.9646447587639216 1.0 1.0 39 Q9Y619,Q969G3,P06280,Q06124 4 +Premature ovarian insufficiency 0.2766059316979966 0.0436455863810022 0.9651869136207596 1.0 1.0 18 Q06787,P40818,P49327,Q96RR1,Q5JTZ9,P57740,Q9H1A4 7 +Abnormality of muscle size 0.2827515944340572 0.0434491413554413 0.9653435055247132 1.0 1.0 171 Q92734,Q8TB36,Q96B26,Q99567,Q16637,O14979,Q8TD16,Q10713,O75477,Q13126,P35637,P04066,P10644,P07737,P22626,Q9C0B1,P16278,Q7LGA3,P50402,Q9Y487,Q96BR5,O43505,Q9BQP7,P10253,P31483,Q92804,P21912,P50995,Q8N0X7,O15270,Q8IWS0,P61978,Q9BW83,Q13501,Q15165,P40818,P35573,P04792,Q15437,Q6DKK2,Q9BVA1 41 +Epicanthus 0.2720727709446058 0.0430808263825622 0.9656371034378743 1.0 1.0 143 Q15392,Q13363,Q10713,P21964,O96028,P10644,P40855,Q08J23,Q03164,Q7LGA3,P11233,P27635,Q9Y487,O43924,P55795,P37268,Q9UHX1,Q15555,Q15067,Q8N0X7,Q96ST3,Q06124,Q02750,Q96PZ0,P07437,O14936,Q9Y2R0 27 +Adrenocortical carcinoma 0.4335132935123221 0.0425014836348751 0.966098929051098 1.0 1.0 3 P10644 1 +Abnormal prostate morphology 0.3360727443399516 0.041453934451849 0.966934016243258 1.0 1.0 5 Q8IWS0,P49959 2 +Sleep wake cycle disturbance 0.3355895974349805 0.0407555667690699 0.9674907624857084 1.0 1.0 5 Q14683,Q9Y4R8,Q05086,Q9UBM7 4 +Horizontal eyebrow 0.3835240314542384 0.0393110064660737 0.9686424315094376 1.0 1.0 4 P11233 1 +Adrenal overactivity 0.3831908831908863 0.0389631654782855 0.9689197559899124 1.0 1.0 4 P17612,P10644,Q01968 3 +Medulloblastoma 0.383190883190885 0.0389631654782844 0.9689197559899134 1.0 1.0 4 Q12824,O96017,P35222 3 +Testicular atrophy 0.3831908831908791 0.0389631654782783 0.9689197559899184 1.0 1.0 4 O76024,Q9NX24,P00492 3 +Abnormal peripheral action potential amplitude 0.3032019795256201 0.038701796636415 0.9691281409753998 1.0 1.0 8 O15270 1 +Central primitive neuroectodermal tumor 0.3829181494661949 0.0380928155131878 0.9696136795443352 1.0 1.0 2 O96017 1 +Choriocarcinoma 0.3829181494661949 0.0380928155131878 0.9696136795443352 1.0 1.0 2 O96017 1 +Flexion contracture of digit 0.255062172597974 0.0376826088095238 0.9699407423075512 1.0 1.0 58 Q15022,Q9BYW2,Q99567,P27635,P18074,Q9UJX6,Q8N0X7,Q8IWS0,Q9Y619,P42892,O75844,P57740,P46109 13 +Mania 0.271808850157586 0.0367861031156213 0.970655554656742 1.0 1.0 14 P21964,P40818,Q9UJS0,P03886 4 +Abnormal 5th finger morphology 0.2452197191352891 0.0364571129121947 0.9709178748961698 1.0 1.0 90 Q14739,Q969G3,O43924,Q8NFH4,Q9Y619,Q53EZ4,Q08J23,Q03164,Q9BW83,Q06124 10 +Visual impairment 0.292653508123386 0.0360538170074577 0.9712394470536834 1.0 1.0 243 Q01105,Q92734,Q96CU9,Q96B26,Q13432,P68371,Q10713,P48449,Q8NHS3,O75503,P40855,P06865,Q08J23,Q96N66,P04439,P16278,Q7LGA3,O43676,Q9Y287,Q96IJ6,P18074,O95831,P01889,Q9NZ08,O43505,Q9H061,Q6P4Q7,P37268,P30533,Q9UHX1,P36404,P50897,P21912,Q15555,Q969G3,Q8IWS0,P49327,P03886,Q8N183,Q7L7X3,O75648,P78318,O00429,P07602,P52701,O14773,Q6DN90,P42858,Q5KU26,P40818,P30153,Q99496,Q96GM5,Q9Y6M9,O94992,Q96PZ0,Q5JPH6,O75306,Q9BVA1,O14936,Q96C86,P17900 62 +Abnormal spinal meningeal morphology 0.3654804270462659 0.0315863810682987 0.9748019043047392 1.0 1.0 2 P31153 1 +Proximal muscle weakness 0.2547599400616378 0.0311165475658307 0.9751765930103587 1.0 1.0 53 Q92734,P50402,P21912,Q16637,Q8TD16,Q13126,P35637,P10253,P51114,Q13501,P22626 11 +Ridged nail 0.3281083006768714 0.0303926388264585 0.9757539155109622 1.0 1.0 5 P19447,P18074,P26639,P16615 4 +Bifid ribs 0.3540925266903959 0.028350255826424 0.9773827983355172 1.0 1.0 2 Q9UM00 1 +Abnormality of the peripheral nervous system 0.244087788314 0.0281160446940826 0.9775695973169752 1.0 1.0 95 Q92734,Q8TB36,Q9Y3I1,Q10713,O60216,P21964,P43243,Q96IJ6,O95831,P06280,O95721,Q8WXW3,Q15067,O15270,Q9Y619,P42892,P04062,Q9BYW2,Q06787,P07602,Q9UJX6,P04792 22 +Abnormal systemic arterial morphology 0.2656423538701928 0.0281078201499071 0.9775761569613002 1.0 1.0 132 P21964,P06865,P16278,P61916,Q7LGA3,P01889,P10253,O75844,Q9UHX1,P46109,P10619,P21912,P03886,O15118,P61978,P04062,Q9BYW2,Q06124,Q06787,P07602,P42858,Q9UJX6,Q02750,Q96PZ0,Q9UBS4,P17900 26 +Patent ductus arteriosus 0.2531649841562313 0.0279065410758671 0.9777366914524688 1.0 1.0 80 Q9BYW2,Q15392,Q969G3,P21964,Q6PGP7,P42892,O75844,Q9UHX1,Q06124 9 +Abnormal morphology of the musculature of the neck 0.2819953323073464 0.0251763613775186 0.9799142918670088 1.0 1.0 11 P35637 1 +Hypoplastic toenails 0.2677718603404332 0.02470160192457 0.9802929773205036 1.0 1.0 20 P23786,Q15022,Q969G3,Q08J23 4 +Tracheal stenosis 0.4047703809184824 0.0242683583292483 0.9806385520895488 1.0 1.0 3 Q96HY6,Q9UBM7 2 +Abnormality of the distal phalanx of the thumb 0.4040583837664696 0.0238992503643006 0.9809329722357918 1.0 1.0 3 O75369,Q69YN2 2 +Abnormality of metacarpophalangeal joint 0.4040583837664687 0.0238992503643001 0.9809329722357922 1.0 1.0 3 P16435,Q15233 2 +Tarsal synostosis 0.4040583837664684 0.0238992503642998 0.9809329722357925 1.0 1.0 3 P16435,O75369 2 +Synostosis involving bones of the lower limbs 0.4040583837664684 0.0238992503642998 0.9809329722357925 1.0 1.0 3 P16435,O75369 2 +Synostosis involving bones of the upper limbs 0.2485193501331924 0.0238172898551489 0.980998348651288 1.0 1.0 25 Q06124 1 +Upper limb undergrowth 0.2710225673188281 0.0235169081797403 0.9812379514376032 1.0 1.0 17 Q14739 1 +Abnormal jejunum morphology 0.3281138790035666 0.0233047018906035 0.9814072211672626 1.0 1.0 2 P49454 1 +Urinary tract neoplasm 0.2544017036609822 0.0227402948902229 0.9818574334628554 1.0 1.0 30 Q15437,P21912 2 +Vaginal neoplasm 0.3639601139601177 0.0210017531194093 0.983244257198012 1.0 1.0 4 Q15645,O60566,P07954 3 +Impaired pain sensation 0.2702077286874779 0.0208083272971313 0.9833985549556864 1.0 1.0 17 P61978,O15270,P04792 3 +Upper limb muscle weakness 0.2562193848848343 0.0207519087137645 0.9834435607541908 1.0 1.0 23 Q92734,P50402,Q8N0X7,Q969G3 4 +Decreased circulating aldosterone level 0.3898184407262427 0.0172642694172384 0.9862257902271888 1.0 1.0 3 Q13423,Q9NNW7 2 +Increased circulating iga level 0.386970452118191 0.0160993237885408 0.98715515298434 1.0 1.0 3 O95394,P49327 2 +Peripheral demyelination 0.2665080710069539 0.0157178522118759 0.9874594847508398 1.0 1.0 15 P03886,P07602 2 +Abnormal circulating dehydroepiandrosterone concentration 0.3830544677821347 0.014580080865825 0.9883671907313856 1.0 1.0 3 Q13423,Q9NNW7 2 +Choroid plexus carcinoma 0.3830544677821315 0.0145800808658239 0.9883671907313863 1.0 1.0 3 Q12824,O96017 2 +Chronic oral candidiasis 0.3826984692061284 0.0144465979503294 0.988473683472464 1.0 1.0 3 O75083,P02786 2 +Abnormal response to endocrine stimulation test 0.3525641025640982 0.0122210263332005 0.9902492744896504 1.0 1.0 4 P16435,Q13423,Q9NNW7 3 +Syringomyelia 0.3115449628118084 0.0103902183808108 0.9917099543317592 1.0 1.0 5 Q9BYW2 1 +Chilblains 0.3497150997151016 0.0102284639871658 0.9918390088066504 1.0 1.0 4 P55265,Q5TBB1,O75792 3 +Moyamoya phenomenon 0.3497150997151016 0.0102284639871658 0.9918390088066504 1.0 1.0 4 P55265,Q5TBB1,O75792 3 +Chronic lymphatic leukemia 0.3497150997151016 0.0102284639871658 0.9918390088066504 1.0 1.0 4 P55265,Q5TBB1,O75792 3 +Neonatal alloimmune thrombocytopenia 0.3497150997151016 0.0102284639871658 0.9918390088066504 1.0 1.0 4 P55265,Q5TBB1,O75792 3 +Chronic leukemia 0.3497150997151016 0.0102284639871658 0.9918390088066504 1.0 1.0 4 P55265,Q5TBB1,O75792 3 +Abnormal 2nd finger morphology 0.368458526165898 0.0097010880616257 0.9922597730197218 1.0 1.0 3 P27635,P21333 2 +Aplasia hypoplasia involving bones of the lower limbs 0.2492420652714377 0.0093377783911066 0.992549639060954 1.0 1.0 83 P15260,Q96A33,Q13363,O60216,Q96AY3,O96028,P10644,Q08J23,Q03164,Q9H1A4,Q7LGA3,O95831,Q96HY6,Q9UHX1,Q06330,Q8N0X7,Q8IWS0,Q9Y619,O00116,O75648,Q06787,P42858,Q99496,Q96PZ0 24 +Elevated circulating parathyroid hormone level 0.3656105375578518 0.0088824876423698 0.9929128934425352 1.0 1.0 3 Q6P1J9,P10644 2 +Abnormal nephron morphology 0.2512207361052511 0.0068338122625747 0.99454744914422 1.0 1.0 58 Q9BW27,P21912,P01889,Q03252,Q9NZ08,P06280,O95470,P49327,P03886,Q8NFH4,O75306,Q14108,Q12769,Q9NQH7,P57740,P23786 16 +Abnormal response to acth stimulation test 0.352438590245643 0.005599248075694 0.995532469752332 1.0 1.0 3 P16435,Q9NNW7 2 +Intrinsic hand muscle atrophy 0.306520013601216 0.0050939006285044 0.9959356729110004 1.0 1.0 5 P31483 1 +Facial edema 0.245581790416931 0.0028111938723258 0.9977569947661892 1.0 1.0 26 Q9BW27,Q8NFH4,P28070,O43707,P57740,Q12769 6 +Incomitant strabismus 0.2615110115409886 0.0015605209233621 0.9987548849537956 1.0 1.0 15 O75648,Q7LGA3,O00429,P42858,Q96PZ0 5 +Semilobar holoprosencephaly 0.3354700854700856 0.0014020429113789 0.9988813319739264 1.0 1.0 4 Q14683,A5YKK6,O94979 3 +Aplasia hypoplasia of the nasal bone 0.3282306870772578 0.0013803067672743 0.998898674890936 1.0 1.0 3 Q6NUK1,P10644 2 +Epicanthus inversus 0.3282306870772551 0.0013803067672738 0.9988986748909364 1.0 1.0 3 Q16531,Q7Z6Z7 2 +Prostate neoplasm 0.334045584045585 0.00061861696779 0.9995064151038312 1.0 1.0 4 O96017,P49959,P04637 3 +Abnormal fallopian tube morphology 0.334045584045585 0.00061861696779 0.9995064151038312 1.0 1.0 4 O96017,P49959,P04637 3 +Primary peritoneal carcinoma 0.334045584045585 0.00061861696779 0.9995064151038312 1.0 1.0 4 O96017,P49959,P04637 3 +Aplasia hypoplasia of the scapulae 0.320398718405132 0.0004193886463345 0.9996653762839228 1.0 1.0 3 P16435,P21333 2 diff --git a/msigdb_hp/selections.json b/msigdb_hp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..a0f0287427f4b6f6d9da96c49a77347661d353e1 --- /dev/null +++ b/msigdb_hp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["11 pairs of ribs", "2 3 finger syndactyly", "2 3 toe cutaneous syndactyly", "2 3 toe syndactyly", "3 4 finger syndactyly", "3 methylglutaconic aciduria", "4 5 toe syndactyly", "Abdominal aortic aneurysm", "Abdominal distention", "Abdominal obesity", "Abdominal pain", "Abdominal wall muscle weakness", "Abducens palsy", "Abnormal 2nd finger morphology", "Abnormal 3rd finger morphology", "Abnormal 5th finger morphology", "Abnormal 5th finger phalanx morphology", "Abnormal abdomen morphology", "Abnormal acetabulum morphology", "Abnormal activity of mitochondrial respiratory chain", "Abnormal adipose tissue morphology", "Abnormal aggressive impulsive or violent behavior", "Abnormal aldolase level", "Abnormal anatomic location of the heart", "Abnormal anterior chamber morphology", "Abnormal anterior eye segment morphology", "Abnormal anterior horn cell morphology", "Abnormal aortic arch morphology", "Abnormal aortic morphology", "Abnormal aortic valve cusp morphology", "Abnormal aortic valve morphology", "Abnormal aortic valve physiology", "Abnormal arachnoid mater morphology", "Abnormal arm span", "Abnormal arterial physiology", "Abnormal astrocyte morphology", "Abnormal atrial arrangement", "Abnormal atrioventricular conduction", "Abnormal atrioventricular valve morphology", "Abnormal atrioventricular valve physiology", "Abnormal auditory evoked potentials", "Abnormal autonomic nervous system physiology", "Abnormal b cell morphology", "Abnormal b cell subset distribution", "Abnormal basal ganglia mri signal intensity", "Abnormal biliary tract morphology", "Abnormal bleeding", "Abnormal blistering of the skin", "Abnormal blood carbon dioxide level", "Abnormal blood chloride concentration", "Abnormal blood gas level", "Abnormal blood glucose concentration", "Abnormal blood inorganic cation concentration", "Abnormal blood ion concentration", "Abnormal blood monovalent inorganic cation concentration", "Abnormal blood phosphate concentration", "Abnormal blood potassium concentration", "Abnormal blood sodium concentration", "Abnormal blood transition element cation concentration", "Abnormal blood zinc concentration", "Abnormal bone structure", "Abnormal brain choline level by mrs", "Abnormal brain lactate level by mrs", "Abnormal brain n acetyl aspartate level by mrs", "Abnormal brain positron emission tomography", "Abnormal brainstem morphology", "Abnormal brainstem mri signal intensity", "Abnormal branching pattern of the aortic arch", "Abnormal breath sound", "Abnormal bronchoalveolar lavage fluid morphology", "Abnormal bronchus morphology", "Abnormal bronchus physiology", "Abnormal c peptide level", "Abnormal c reactive protein level", "Abnormal calcium phosphate regulating hormone level", "Abnormal cardiac atrium morphology", "Abnormal cardiac septum morphology", "Abnormal cardiac test", "Abnormal cardiac ventricle morphology", "Abnormal cardiac ventricular function", "Abnormal cardiomyocyte morphology", "Abnormal carotid artery morphology", "Abnormal cartilage morphology", "Abnormal caudate nucleus morphology", "Abnormal cd4 cd8 ratio", "Abnormal cell morphology", "Abnormal cell proliferation", "Abnormal cellular composition of bronchoalveolar fluid", "Abnormal cellular phenotype", "Abnormal central sensory function", "Abnormal cerebellar vermis morphology", "Abnormal cerebral artery morphology", "Abnormal cerebral cortex morphology", "Abnormal cerebral vascular morphology", "Abnormal cerebral vein morphology", "Abnormal cerebral ventricle morphology", "Abnormal cerebrospinal fluid metabolite concentration", "Abnormal cervical curvature", "Abnormal cervical spine morphology", "Abnormal chorioretinal morphology", "Abnormal choroid morphology", "Abnormal choroid plexus morphology", "Abnormal chromosome morphology", "Abnormal ciliary body morphology", "Abnormal circulating acetylcarnitine concentration", "Abnormal circulating albumin concentration", "Abnormal circulating amino acid concentration", "Abnormal circulating amylase level", "Abnormal circulating androgen level", "Abnormal circulating apolipoprotein concentration", "Abnormal circulating arginine concentration", "Abnormal circulating aromatic amino acid concentration", "Abnormal circulating aspartate family amino acid concentration", "Abnormal circulating bilirubin concentration", "Abnormal circulating branched chain amino acid concentration", "Abnormal circulating carbohydrate concentration", "Abnormal circulating carboxylic acid concentration", "Abnormal circulating ceruloplasmin concentration", "Abnormal circulating cholesterol concentration", "Abnormal circulating citrulline concentration", "Abnormal circulating copper concentration", "Abnormal circulating creatinine concentration", "Abnormal circulating dehydroepiandrosterone concentration", "Abnormal circulating dicarboxylic acid concentration", "Abnormal circulating estrogen level", "Abnormal circulating fatty acid anion concentration", "Abnormal circulating fatty acid concentration", "Abnormal circulating ferritin concentration", "Abnormal circulating follicle stimulating hormone concentration", "Abnormal circulating free fatty acid concentration", "Abnormal circulating gaba concentration", "Abnormal circulating glutamine concentration", "Abnormal circulating glutamine family amino acid concentration", "Abnormal circulating glycine concentration", "Abnormal circulating gonadotropin concentration", "Abnormal circulating hormone concentration", "Abnormal circulating iga level", "Abnormal circulating ige level", "Abnormal circulating igg level", "Abnormal circulating igm level", "Abnormal circulating inhibin level", "Abnormal circulating lipid concentration", "Abnormal circulating long chain fatty acid concentration", "Abnormal circulating metabolite concentration", "Abnormal circulating methionine concentration", "Abnormal circulating monocarboxylic acid cocentration", "Abnormal circulating nitrogen compound concentration", "Abnormal circulating non proteinogenic amino acid concentration", "Abnormal circulating nucleobase concentration", "Abnormal circulating phenylalanine concentration", "Abnormal circulating porphyrin concentration", "Abnormal circulating progesterone level", "Abnormal circulating proline concentration", "Abnormal circulating protein concentration", "Abnormal circulating proteinogenic amino acid concentration", "Abnormal circulating proteinogenic amino acid derivative concentration", "Abnormal circulating pyruvate family amino acid concentration", "Abnormal circulating renin", "Abnormal circulating serine concentration", "Abnormal circulating serine family amino acid concentration", "Abnormal circulating sex hormone concentration", "Abnormal circulating sulfur amino acid concentration", "Abnormal circulating tyrosine concentration", "Abnormal clavicle morphology", "Abnormal cns myelination", "Abnormal cochlea morphology", "Abnormal conjugate eye movement", "Abnormal conjunctiva morphology", "Abnormal connection of the cardiac segments", "Abnormal consumption behavior", "Abnormal conus terminalis morphology", "Abnormal cornea morphology", "Abnormal corneal epithelium morphology", "Abnormal coronary artery morphology", "Abnormal corpus callosum morphology", "Abnormal corpus striatum morphology", "Abnormal cortical bone morphology", "Abnormal cortical gyration", "Abnormal cranial nerve morphology", "Abnormal cranial nerve physiology", "Abnormal cry", "Abnormal csf carboxylic acid concentration", "Abnormal csf metabolite level", "Abnormal csf protein level", "Abnormal csf pyruvate family amino acid concentration", "Abnormal cutaneous elastic fiber morphology", "Abnormal delayed hypersensitivity skin test", "Abnormal delivery", "Abnormal dense granules", "Abnormal dental pulp morphology", "Abnormal dental root morphology", "Abnormal dentate nucleus morphology", "Abnormal dentin morphology", "Abnormal dermatoglyphics", "Abnormal dermoepidermal junction morphology", "Abnormal diaphysis morphology", "Abnormal distal phalanx morphology of finger", "Abnormal dlco", "Abnormal drinking behavior", "Abnormal duodenum morphology", "Abnormal dura mater morphology", "Abnormal eating behavior", "Abnormal echocardiogram", "Abnormal elasticity of skin", "Abnormal electrophysiology of sinoatrial node origin", "Abnormal electroretinogram", "Abnormal emotion affect behavior", "Abnormal enchondral ossification", "Abnormal endocardium morphology", "Abnormal endocrine physiology", "Abnormal enzyme coenzyme activity", "Abnormal eosinophil morphology", "Abnormal epidermal morphology", "Abnormal epiglottis morphology", "Abnormal epiphyseal ossification", "Abnormal epiphysis morphology of the phalanges of the hand", "Abnormal erythrocyte enzyme level", "Abnormal erythrocyte morphology", "Abnormal erythrocyte physiology", "Abnormal erythrocyte sedimentation rate", "Abnormal esophagus morphology", "Abnormal esophagus physiology", "Abnormal external genitalia", "Abnormal exteroceptive sensation", "Abnormal eyebrow morphology", "Abnormal eyelash morphology", "Abnormal eyelid morphology", "Abnormal eyelid physiology", "Abnormal facial expression", "Abnormal facial shape", "Abnormal factor ix activity", "Abnormal fallopian tube morphology", "Abnormal fear anxiety related behavior", "Abnormal female reproductive system physiology", "Abnormal femoral head morphology", "Abnormal femoral neck head morphology", "Abnormal femoral neck morphology", "Abnormal finger phalanx morphology", "Abnormal fingernail morphology", "Abnormal fingertip morphology", "Abnormal foot bone ossification", "Abnormal foramen magnum morphology", "Abnormal forearm bone morphology", "Abnormal form of the vertebral bodies", "Abnormal foveal morphology", "Abnormal full field electroretinogram", "Abnormal fundus autofluorescence imaging", "Abnormal gallbladder morphology", "Abnormal gastrointestinal motility", "Abnormal glial cell morphology", "Abnormal globus pallidus morphology", "Abnormal glomerular basement membrane morphology", "Abnormal glomerular filtration rate", "Abnormal glomerular mesangial cellularity", "Abnormal glomerular mesangium morphology", "Abnormal glucose homeostasis", "Abnormal glycosylation", "Abnormal granulocyte count", "Abnormal granulocytopoietic cell morphology", "Abnormal greater sciatic notch morphology", "Abnormal growth hormone level", "Abnormal hair laboratory examination", "Abnormal hair morphology", "Abnormal hair pattern", "Abnormal hair quantity", "Abnormal hair whorl", "Abnormal hand bone ossification", "Abnormal hand morphology", "Abnormal hdl cholesterol concentration", "Abnormal head movements", "Abnormal heart rate variability", "Abnormal heart sound", "Abnormal heart valve morphology", "Abnormal heart valve physiology", "Abnormal hemoglobin", "Abnormal hemoglobin concentration", "Abnormal hepatic iron concentration", "Abnormal humerus morphology", "Abnormal hypothalamus morphology", "Abnormal hypothalamus physiology", "Abnormal ileum morphology", "Abnormal iliac wing morphology", "Abnormal ilium morphology", "Abnormal immune system morphology", "Abnormal incisor morphology", "Abnormal inflammatory response", "Abnormal insulin level", "Abnormal internal carotid artery morphology", "Abnormal internal genitalia", "Abnormal intestine morphology", "Abnormal intraocular pressure", "Abnormal involuntary eye movements", "Abnormal iris pigmentation", "Abnormal jaw morphology", "Abnormal jejunum morphology", "Abnormal joint morphology", "Abnormal labia majora morphology", "Abnormal labia minora morphology", "Abnormal labia morphology", "Abnormal lacrimal duct morphology", "Abnormal lacrimal gland morphology", "Abnormal lacrimal punctum morphology", "Abnormal lactate dehydrogenase level", "Abnormal large intestine morphology", "Abnormal large intestine physiology", "Abnormal larynx morphology", "Abnormal larynx physiology", "Abnormal lateral ventricle morphology", "Abnormal ldl cholesterol concentration", "Abnormal left atrium morphology", "Abnormal left ventricle morphology", "Abnormal left ventricular outflow tract morphology", "Abnormal length of corpus callosum", "Abnormal leukocyte count", "Abnormal leukocyte physiology", "Abnormal levels of alpha fetoprotein", "Abnormal libido", "Abnormal light and dark adapted electroretinogram", "Abnormal lip morphology", "Abnormal liver morphology", "Abnormal liver parenchyma morphology", "Abnormal liver physiology", "Abnormal localization of kidney", "Abnormal location of ears", "Abnormal lower limb bone morphology", "Abnormal lower motor neuron morphology", "Abnormal lumbar spine morphology", "Abnormal lung development", "Abnormal lung lobation", "Abnormal lymphatic vessel morphology", "Abnormal lymphocyte morphology", "Abnormal macrophage morphology", "Abnormal macroscopic urine appearance", "Abnormal macular morphology", "Abnormal magnesium concentration", "Abnormal male reproductive system physiology", "Abnormal mandibular ramus morphology", "Abnormal mean corpuscular hemoglobin concentration", "Abnormal mean corpuscular volume", "Abnormal megakaryocyte morphology", "Abnormal meningeal morphology", "Abnormal metabolic brain imaging by mrs", "Abnormal metabolism", "Abnormal metacarpal morphology", "Abnormal metaphyseal trabeculation", "Abnormal metatarsal morphology", "Abnormal midbrain morphology", "Abnormal middle phalanx morphology of the hand", "Abnormal mitochondria in muscle tissue", "Abnormal mitochondrial morphology", "Abnormal mitochondrial number", "Abnormal mitochondrial shape", "Abnormal mitral valve physiology", "Abnormal monocyte morphology", "Abnormal morphology of myocardial trabeculae", "Abnormal morphology of the abdominal musculature", "Abnormal morphology of the choroidal vasculature", "Abnormal morphology of the conjunctival vasculature", "Abnormal morphology of the great vessels", "Abnormal morphology of the limbic system", "Abnormal morphology of the musculature of the neck", "Abnormal morphology of the olfactory bulb", "Abnormal morphology of the radius", "Abnormal motor evoked potentials", "Abnormal motor nerve conduction velocity", "Abnormal muscle fiber morphology", "Abnormal muscle fiber protein expression", "Abnormal muscle fiber type distribution", "Abnormal muscle glycogen content", "Abnormal myelination", "Abnormal myeloid cell morphology", "Abnormal myeloid leukocyte morphology", "Abnormal myocardium morphology", "Abnormal nasal base", "Abnormal nasal bridge morphology", "Abnormal nasal mucosa morphology", "Abnormal nasolacrimal system morphology", "Abnormal natural killer cell morphology", "Abnormal natural killer cell physiology", "Abnormal nephron morphology", "Abnormal nerve conduction velocity", "Abnormal nervous system electrophysiology", "Abnormal neural tube morphology", "Abnormal neuron morphology", "Abnormal neutrophil count", "Abnormal nipple morphology", "Abnormal number of erythroid precursors", "Abnormal number of granulocyte precursors", "Abnormal number of incisors", "Abnormal number of permanent teeth", "Abnormal number of teeth", "Abnormal odontoid tissue morphology", "Abnormal optical coherence tomography", "Abnormal oral frenulum morphology", "Abnormal oral glucose tolerance", "Abnormal oral mucosa morphology", "Abnormal oral physiology", "Abnormal ossification involving the femoral head and neck", "Abnormal ovarian morphology", "Abnormal ovarian physiology", "Abnormal palate morphology", "Abnormal palmar dermatoglyphics", "Abnormal pancreas morphology", "Abnormal pancreas size", "Abnormal paranasal sinus morphology", "Abnormal parietal bone morphology", "Abnormal parotid gland morphology", "Abnormal patella morphology", "Abnormal pattern of respiration", "Abnormal pelvis bone morphology", "Abnormal pelvis bone ossification", "Abnormal penis morphology", "Abnormal pericardium morphology", "Abnormal perifollicular morphology", "Abnormal peripheral action potential amplitude", "Abnormal peripheral myelination", "Abnormal peripheral nervous system morphology", "Abnormal peripheral nervous system physiology", "Abnormal peristalsis", "Abnormal periventricular white matter morphology", "Abnormal phalangeal joint morphology of the hand", "Abnormal pharynx morphology", "Abnormal pigmentation of the oral mucosa", "Abnormal pineal morphology", "Abnormal placenta morphology", "Abnormal placental membrane morphology", "Abnormal placental size", "Abnormal platelet aggregation", "Abnormal platelet function", "Abnormal platelet granules", "Abnormal platelet morphology", "Abnormal platelet volume", "Abnormal pleura morphology", "Abnormal pons morphology", "Abnormal posterior segment imaging", "Abnormal pr interval", "Abnormal preputium morphology", "Abnormal prolactin level", "Abnormal proportion of cd4 positive t cells", "Abnormal proportion of cd8 positive t cells", "Abnormal proportion of class switched memory b cells", "Abnormal proportion of double negative alpha beta regulatory t cell", "Abnormal prostate morphology", "Abnormal protein glycosylation", "Abnormal protein o linked glycosylation", "Abnormal proximal phalanx morphology of the hand", "Abnormal pulmonary interstitial morphology", "Abnormal pulmonary thoracic imaging finding", "Abnormal pulmonary valve morphology", "Abnormal pulmonary valve physiology", "Abnormal pupil morphology", "Abnormal pupillary function", "Abnormal pupillary light reflex", "Abnormal pyramidal sign", "Abnormal qrs complex", "Abnormal qt interval", "Abnormal rectum morphology", "Abnormal reflex", "Abnormal renal collecting system morphology", "Abnormal renal cortex morphology", "Abnormal renal corticomedullary differentiation", "Abnormal renal echogenicity", "Abnormal renal insterstitial morphology", "Abnormal renal medulla morphology", "Abnormal renal morphology", "Abnormal renal pelvis morphology", "Abnormal renal physiology", "Abnormal renal resorption", "Abnormal renal tubule morphology", "Abnormal renal vascular morphology", "Abnormal respiratory motile cilium morphology", "Abnormal respiratory motile cilium physiology", "Abnormal respiratory system morphology", "Abnormal response to acth stimulation test", "Abnormal response to endocrine stimulation test", "Abnormal response to insulin tolerance test", "Abnormal reticulocyte morphology", "Abnormal retinal artery morphology", "Abnormal retinal morphology", "Abnormal retinal vascular morphology", "Abnormal rib cage morphology", "Abnormal rib ossification", "Abnormal right atrium morphology", "Abnormal right ventricle morphology", "Abnormal saccadic eye movements", "Abnormal sacroiliac joint morphology", "Abnormal sacrum morphology", "Abnormal salivary gland morphology", "Abnormal sarcomere morphology", "Abnormal scalp morphology", "Abnormal scapula morphology", "Abnormal sclera morphology", "Abnormal sella turcica morphology", "Abnormal sensory nerve conduction velocity", "Abnormal serum insulin like growth factor 1 level", "Abnormal serum interferon level", "Abnormal serum interleukin level", "Abnormal serum iron concentration", "Abnormal sex determination", "Abnormal shape of the frontal region", "Abnormal shape of the occiput", "Abnormal shape of the palpebral fissure", "Abnormal sharpey fiber morphology", "Abnormal shoulder morphology", "Abnormal shoulder physiology", "Abnormal size of pituitary gland", "Abnormal size of the clitoris", "Abnormal size of the dental root", "Abnormal size of the palpebral fissures", "Abnormal skin morphology of the palm", "Abnormal social behavior", "Abnormal soft palate morphology", "Abnormal speech prosody", "Abnormal sperm motility", "Abnormal spermatogenesis", "Abnormal spinal meningeal morphology", "Abnormal sputum", "Abnormal st segment", "Abnormal sternal ossification", "Abnormal sternum morphology", "Abnormal stomach morphology", "Abnormal stool composition", "Abnormal subarachnoid space morphology", "Abnormal subclavian artery morphology", "Abnormal subcutaneous fat tissue distribution", "Abnormal substantia nigra morphology", "Abnormal superior cerebellar peduncle morphology", "Abnormal sweat gland morphology", "Abnormal sweat homeostasis", "Abnormal synaptic transmission at the neuromuscular junction", "Abnormal systemic arterial morphology", "Abnormal systemic blood pressure", "Abnormal t cell activation", "Abnormal t cell morphology", "Abnormal t cell proliferation", "Abnormal t cell subset distribution", "Abnormal t wave", "Abnormal talus morphology", "Abnormal temper tantrums", "Abnormal temporal bone morphology", "Abnormal tendon morphology", "Abnormal testis morphology", "Abnormal thalamic mri signal intensity", "Abnormal thalamic size", "Abnormal thoracic spine morphology", "Abnormal thorax morphology", "Abnormal thrombocyte morphology", "Abnormal thrombosis", "Abnormal thumb morphology", "Abnormal thyroid hormone level", "Abnormal thyroid morphology", "Abnormal thyroid stimulating hormone level", "Abnormal tissue metabolite concentration", "Abnormal toenail morphology", "Abnormal tongue morphology", "Abnormal tongue physiology", "Abnormal trabecular bone morphology", "Abnormal tracheal morphology", "Abnormal tracheobronchial morphology", "Abnormal transferrin saturation", "Abnormal tricuspid valve morphology", "Abnormal tricuspid valve physiology", "Abnormal umbilicus morphology", "Abnormal upper limb bone morphology", "Abnormal upper motor neuron morphology", "Abnormal ureter morphology", "Abnormal ureter physiology", "Abnormal urinary color", "Abnormal urinary electrolyte concentration", "Abnormal urine alpha ketoglutarate concentration", "Abnormal urine carbohydrate level", "Abnormal urine carboxylic acid level", "Abnormal urine cytology", "Abnormal urine hormone level", "Abnormal urine magnesium concentration", "Abnormal urine metabolite level", "Abnormal urine ph", "Abnormal urine phosphate concentration", "Abnormal urine potassium concentration", "Abnormal urine protein level", "Abnormal urine sodium concentration", "Abnormal uterus morphology", "Abnormal uvea morphology", "Abnormal uvula morphology", "Abnormal vagina morphology", "Abnormal vascular morphology", "Abnormal vascular physiology", "Abnormal vena cava morphology", "Abnormal venous morphology", "Abnormal ventricular septum morphology", "Abnormal vertebral morphology", "Abnormal vertebral segmentation and fusion", "Abnormal vestibulo ocular reflex", "Abnormal visual electrophysiology", "Abnormal visual field test", "Abnormal visual fixation", "Abnormal vitamin b12 level", "Abnormal vitreous humor morphology", "Abnormal waist to hip ratio", "Abnormal z disc morphology", "Abnormalities of placenta or umbilical cord", "Abnormality iris morphology", "Abnormality of abdominal situs", "Abnormality of acid base homeostasis", "Abnormality of adrenal morphology", "Abnormality of adrenal physiology", "Abnormality of alkaline phosphatase level", "Abnormality of amino acid metabolism", "Abnormality of bladder morphology", "Abnormality of blood circulation", "Abnormality of blood volume homeostasis", "Abnormality of body mass index", "Abnormality of bone marrow cell morphology", "Abnormality of bone mineral density", "Abnormality of canine", "Abnormality of cardiovascular system electrophysiology", "Abnormality of carpal bone ossification", "Abnormality of cartilage of external ear", "Abnormality of central nervous system electrophysiology", "Abnormality of chorioretinal pigmentation", "Abnormality of chromosome segregation", "Abnormality of chromosome stability", "Abnormality of circulating adrenocorticotropin level", "Abnormality of circulating enzyme level", "Abnormality of circulating fibrinogen", "Abnormality of circulating glucocorticoid level", "Abnormality of circulating leptin level", "Abnormality of coagulation", "Abnormality of complement system", "Abnormality of coordination", "Abnormality of corneal size", "Abnormality of corneal stroma", "Abnormality of corneal thickness", "Abnormality of cranial sutures", "Abnormality of dental color", "Abnormality of dental eruption", "Abnormality of dental morphology", "Abnormality of dental structure", "Abnormality of dermal melanosomes", "Abnormality of digestive system morphology", "Abnormality of dna repair", "Abnormality of earlobe", "Abnormality of endocrine pancreas physiology", "Abnormality of epiphysis morphology", "Abnormality of exocrine pancreas physiology", "Abnormality of extrapyramidal motor function", "Abnormality of facial adipose tissue", "Abnormality of facial musculature", "Abnormality of facial skeleton", "Abnormality of facial soft tissue", "Abnormality of female external genitalia", "Abnormality of femur morphology", "Abnormality of fibula morphology", "Abnormality of finger", "Abnormality of fluid regulation", "Abnormality of folate metabolism", "Abnormality of fontanelles", "Abnormality of foveal pigmentation", "Abnormality of frontal sinus", "Abnormality of frontalis muscle belly", "Abnormality of fundus pigmentation", "Abnormality of globe location", "Abnormality of globe size", "Abnormality of glycolipid metabolism", "Abnormality of hair growth", "Abnormality of hair pigmentation", "Abnormality of hair texture", "Abnormality of hand joint mobility", "Abnormality of head blood vessel", "Abnormality of hepatobiliary system physiology", "Abnormality of hindbrain morphology", "Abnormality of humoral immunity", "Abnormality of immune serum protein physiology", "Abnormality of iron homeostasis", "Abnormality of krebs cycle metabolism", "Abnormality of lens shape", "Abnormality of limb epiphysis morphology", "Abnormality of lipoprotein cholesterol concentration", "Abnormality of long bone morphology", "Abnormality of lower limb epiphysis morphology", "Abnormality of lower limb joint", "Abnormality of lower limb metaphyses", "Abnormality of lower lip", "Abnormality of lysosomal metabolism", "Abnormality of macular pigmentation", "Abnormality of malar bones", "Abnormality of male internal genitalia", "Abnormality of masticatory muscle", "Abnormality of metacarpal epiphyses", "Abnormality of metacarpophalangeal joint", "Abnormality of mouth shape", "Abnormality of mouth size", "Abnormality of muscle size", "Abnormality of nail color", "Abnormality of neuronal migration", "Abnormality of neutrophil morphology", "Abnormality of neutrophil physiology", "Abnormality of neutrophils", "Abnormality of ocular smooth pursuit", "Abnormality of pain sensation", "Abnormality of pancreas physiology", "Abnormality of pelvic girdle bone morphology", "Abnormality of periauricular region", "Abnormality of peripheral nerves", "Abnormality of prenatal development or birth", "Abnormality of primary teeth", "Abnormality of prothrombin", "Abnormality of pulmonary circulation", "Abnormality of refraction", "Abnormality of renal excretion", "Abnormality of renin angiotensin system", "Abnormality of reproductive system physiology", "Abnormality of retinal pigmentation", "Abnormality of salivation", "Abnormality of secondary sexual hair", "Abnormality of skeletal maturation", "Abnormality of skeletal muscle fiber size", "Abnormality of skin adnexa physiology", "Abnormality of skin physiology", "Abnormality of skin pigmentation", "Abnormality of skull ossification", "Abnormality of small intestinal villus morphology", "Abnormality of somatosensory evoked potentials", "Abnormality of subcutaneous fat tissue", "Abnormality of t cell physiology", "Abnormality of taste sensation", "Abnormality of temperature regulation", "Abnormality of thalamus morphology", "Abnormality of the 1st metacarpal", "Abnormality of the 2nd toe", "Abnormality of the 3rd toe", "Abnormality of the 4th metacarpal", "Abnormality of the 5th metacarpal", "Abnormality of the 5th toe", "Abnormality of the abdominal organs", "Abnormality of the abdominal wall", "Abnormality of the achilles tendon", "Abnormality of the adrenal glands", "Abnormality of the alveolar ridges", "Abnormality of the amniotic fluid", "Abnormality of the ankles", "Abnormality of the anterior fontanelle", "Abnormality of the antihelix", "Abnormality of the antitragus", "Abnormality of the anus", "Abnormality of the auditory canal", "Abnormality of the autonomic nervous system", "Abnormality of the axillary hair", "Abnormality of the basal ganglia", "Abnormality of the biliary system", "Abnormality of the bladder", "Abnormality of the brainstem white matter", "Abnormality of the breast", "Abnormality of the calcaneus", "Abnormality of the calf", "Abnormality of the calf musculature", "Abnormality of the calvaria", "Abnormality of the carpal bones", "Abnormality of the cerebral subcortex", "Abnormality of the cerebrospinal fluid", "Abnormality of the cervical spine", "Abnormality of the cheek", "Abnormality of the chin", "Abnormality of the choanae", "Abnormality of the clitoris", "Abnormality of the coagulation cascade", "Abnormality of the columella", "Abnormality of the common coagulation pathway", "Abnormality of the costochondral junction", "Abnormality of the crus of the helix", "Abnormality of the curvature of the cornea", "Abnormality of the curvature of the vertebral column", "Abnormality of the dentition", "Abnormality of the diaphragm", "Abnormality of the diencephalon", "Abnormality of the distal phalanges of the toes", "Abnormality of the distal phalanx of the thumb", "Abnormality of the dorsal column of the spinal cord", "Abnormality of the elbow", "Abnormality of the endometrium", "Abnormality of the epididymis", "Abnormality of the epiphyses of the distal phalanx of finger", "Abnormality of the external nose", "Abnormality of the extraocular muscles", "Abnormality of the extrinsic pathway", "Abnormality of the female genitalia", "Abnormality of the fetal cardiovascular system", "Abnormality of the fifth metatarsal bone", "Abnormality of the fontanelles or cranial sutures", "Abnormality of the foot musculature", "Abnormality of the forearm", "Abnormality of the forehead", "Abnormality of the frontal hairline", "Abnormality of the gallbladder", "Abnormality of the gastric mucosa", "Abnormality of the gingiva", "Abnormality of the glabella", "Abnormality of the glenoid fossa", "Abnormality of the hairline", "Abnormality of the hallux", "Abnormality of the helix", "Abnormality of the hepatic vasculature", "Abnormality of the humeroradial joint", "Abnormality of the humerus", "Abnormality of the hypothalamus pituitary axis", "Abnormality of the hypothenar eminence", "Abnormality of the incisor", "Abnormality of the inner ear", "Abnormality of the internal auditory canal", "Abnormality of the intervertebral disk", "Abnormality of the intrahepatic bile duct", "Abnormality of the intrinsic pathway", "Abnormality of the ischium", "Abnormality of the kidney", "Abnormality of the knee", "Abnormality of the larynx", "Abnormality of the lens", "Abnormality of the leydig cells", "Abnormality of the liver", "Abnormality of the lower urinary tract", "Abnormality of the lymph nodes", "Abnormality of the lymphatic system", "Abnormality of the mastoid", "Abnormality of the maxilla", "Abnormality of the menstrual cycle", "Abnormality of the metacarpal bones", "Abnormality of the metaphysis", "Abnormality of the metopic suture", "Abnormality of the middle ear", "Abnormality of the middle ear ossicles", "Abnormality of the middle phalanges of the toes", "Abnormality of the middle phalanx of the 5th finger", "Abnormality of the midface", "Abnormality of the mitochondrion", "Abnormality of the musculature of the hand", "Abnormality of the musculature of the limbs", "Abnormality of the musculature of the lower limbs", "Abnormality of the musculature of the thigh", "Abnormality of the musculature of the upper arm", "Abnormality of the musculature of the upper limbs", "Abnormality of the nail", "Abnormality of the nasal alae", "Abnormality of the nasal bone", "Abnormality of the nasal cavity", "Abnormality of the nasal dorsum", "Abnormality of the nasal septum", "Abnormality of the nasal skeleton", "Abnormality of the nasal tip", "Abnormality of the nasolabial region", "Abnormality of the neck", "Abnormality of the odontoid process", "Abnormality of the optic nerve", "Abnormality of the outer ear", "Abnormality of the ovary", "Abnormality of the palm", "Abnormality of the palpebral fissures", "Abnormality of the pancreas", "Abnormality of the parathyroid gland", "Abnormality of the parathyroid morphology", "Abnormality of the periorbital region", "Abnormality of the peripheral nervous system", "Abnormality of the peritoneum", "Abnormality of the periungual region", "Abnormality of the phalanges of the hallux", "Abnormality of the phalanges of the toes", "Abnormality of the pharynx", "Abnormality of the philtrum", "Abnormality of the pineal gland", "Abnormality of the pinna", "Abnormality of the pituitary gland", "Abnormality of the plantar skin of foot", "Abnormality of the posterior pituitary", "Abnormality of the protein c anticoagulant pathway", "Abnormality of the proximal phalanx of the thumb", "Abnormality of the pubic bone", "Abnormality of the pubic hair", "Abnormality of the pulmonary artery", "Abnormality of the pulmonary vasculature", "Abnormality of the pulmonary veins", "Abnormality of the pylorus", "Abnormality of the radial head", "Abnormality of the radioulnar joints", "Abnormality of the ribs", "Abnormality of the scrotum", "Abnormality of the sense of smell", "Abnormality of the septum pellucidum", "Abnormality of the shoulder girdle musculature", "Abnormality of the skull base", "Abnormality of the small intestine", "Abnormality of the spinal cord", "Abnormality of the spleen", "Abnormality of the stapes", "Abnormality of the subungual region", "Abnormality of the supraorbital ridges", "Abnormality of the synovia", "Abnormality of the tarsal bones", "Abnormality of the temporomandibular joint", "Abnormality of the testis size", "Abnormality of the thenar eminence", "Abnormality of the thoracic cavity", "Abnormality of the thymus", "Abnormality of the thyroid gland", "Abnormality of the tongue", "Abnormality of the tonsils", "Abnormality of the tragus", "Abnormality of the ulna", "Abnormality of the umbilical cord", "Abnormality of the upper arm", "Abnormality of the upper respiratory tract", "Abnormality of the ureter", "Abnormality of the urethra", "Abnormality of the urinary system physiology", "Abnormality of the uterus", "Abnormality of the vasculature of the eye", "Abnormality of the vertebral endplates", "Abnormality of the vestibulocochlear nerve", "Abnormality of the voice", "Abnormality of the wrist", "Abnormality of the zygomatic bone", "Abnormality of thyroid physiology", "Abnormality of tibia morphology", "Abnormality of toe", "Abnormality of ulnar metaphysis", "Abnormality of upper limb epiphysis morphology", "Abnormality of upper limb joint", "Abnormality of upper limb metaphysis", "Abnormality of upper lip", "Abnormality of upper lip vermillion", "Abnormality of urinary uric acid concentration", "Abnormality of urine calcium concentration", "Abnormality of urine catecholamine concentration", "Abnormality of urine homeostasis", "Abnormality of visual evoked potentials", "Abnormality of vitamin a metabolism", "Abnormality of vitamin b metabolism", "Abnormality of vitamin b12 metabolism", "Abnormality of vitamin d metabolism", "Abnormality of vitamin e metabolism", "Abnormality of vitamin k metabolism", "Abnormality of vitamin metabolism", "Abnormality on pulmonary function testing", "Abnormally folded helix", "Abnormally large globe", "Abnormally lax or hyperextensible skin", "Abnormally low pitched voice", "Abnormally ossified vertebrae", "Abnormally shaped carpal bones", "Abscess", "Absence of pubertal development", "Absence of secondary sex characteristics", "Absence of subcutaneous fat", "Absent axillary hair", "Absent brainstem auditory responses", "Absent distal phalanges", "Absent earlobe", "Absent epiphyses", "Absent eyebrow", "Absent facial hair", "Absent fingernail", "Absent forearm bone", "Absent frontal sinuses", "Absent hair", "Absent hand", "Absent hypoplastic paranasal sinuses", "Absent lacrimal punctum", "Absent nares", "Absent nipple", "Absent or minimally ossified vertebral bodies", "Absent outer dynein arms", "Absent palmar crease", "Absent septum pellucidum", "Absent shortened dynein arms", "Absent speech", "Absent sternal ossification", "Absent testis", "Absent thumb", "Absent thumbnail", "Absent toe", "Absent toenail", "Acanthocytosis", "Acantholysis", "Acanthosis nigricans", "Accelerated atherosclerosis", "Accelerated skeletal maturation", "Accessory oral frenulum", "Accessory spleen", "Acetabular dysplasia", "Achilles tendon contracture", "Achromatopsia", "Acidemia", "Acne", "Acne inversa", "Acquired abnormal hair pattern", "Acral blistering", "Acral ulceration", "Acromesomelia", "Acroparesthesia", "Action tremor", "Acute coronary syndrome", "Acute encephalopathy", "Acute hepatic failure", "Acute kidney injury", "Acute leukemia", "Acute lymphoblastic leukemia", "Acute myeloid leukemia", "Acute pancreatitis", "Acute phase response", "Addictive behavior", "Adducted thumb", "Adenocarcinoma of the colon", "Adenocarcinoma of the intestines", "Adenocarcinoma of the small intestine", "Adenoma sebaceum", "Adenomatous colonic polyposis", "Adipose tissue loss", "Adrenal hyperplasia", "Adrenal hypoplasia", "Adrenal insufficiency", "Adrenal overactivity", "Adrenocortical abnormality", "Adrenocortical carcinoma", "Adrenocorticotropic hormone deficiency", "Adrenocorticotropic hormone excess", "Adrenocorticotropin deficient adrenal insufficiency", "Adult onset", "Advanced eruption of teeth", "Advanced ossification of carpal bones", "Agammaglobulinemia", "Aganglionic megacolon", "Agenesis of central incisor", "Agenesis of cerebellar vermis", "Agenesis of corpus callosum", "Agenesis of incisor", "Agenesis of lateral incisor", "Agenesis of maxillary incisor", "Agenesis of permanent teeth", "Aggressive behavior", "Agitation", "Agnosia", "Agyria", "Airway obstruction", "Akinesia", "Alacrima", "Albinism", "Albuminuria", "Alexia", "Alkalosis", "Allergic rhinitis", "Allergy", "Alopecia", "Alopecia of scalp", "Alopecia totalis", "Alopecia universalis", "Alternating esotropia", "Alveolar cell carcinoma", "Alveolar ridge overgrowth", "Amaurosis fugax", "Ambiguous genitalia", "Ambiguous genitalia female", "Ambiguous genitalia male", "Amblyopia", "Amegakaryocytic thrombocytopenia", "Amelogenesis imperfecta", "Amenorrhea", "Aminoaciduria", "Amniotic constriction ring", "Amyloidosis", "Amyotrophic lateral sclerosis", "Anal atresia", "Anal stenosis", "Anarthria", "Anasarca", "Anemia of inadequate production", "Anemic pallor", "Anencephaly", "Angina pectoris", "Angioedema", "Angiofibromas", "Angioid streaks of the fundus", "Angiokeratoma", "Angular cheilitis", "Anhidrosis", "Aniridia", "Anisocoria", "Anisocytosis", "Anisopoikilocytosis", "Anisospondyly", "Ankle clonus", "Ankle flexion contracture", "Ankle weakness", "Ankyloblepharon", "Ankyloglossia", "Ankylosis", "Annular pancreas", "Anodontia", "Anomalous trichromacy", "Anomic aphasia", "Anonychia", "Anophthalmia", "Anorectal anomaly", "Anorexia", "Anosmia", "Anotia", "Antenatal onset", "Anterior open bite malocclusion", "Anterior pituitary dysgenesis", "Anterior plagiocephaly", "Anterior rib cupping", "Anterior uveitis", "Anteriorly placed anus", "Anteverted ears", "Anti thyroid peroxidase antibody positivity", "Antineutrophil antibody positivity", "Antinuclear antibody positivity", "Antiphospholipid antibody positivity", "Aortic aneurysm", "Aortic arch aneurysm", "Aortic atherosclerotic lesion", "Aortic dissection", "Aortic regurgitation", "Aortic root aneurysm", "Aortic valve calcification", "Aortic valve stenosis", "Aphasia", "Aphthous ulcer", "Aplasia cutis congenita", "Aplasia cutis congenita of scalp", "Aplasia cutis congenita on trunk or limbs", "Aplasia cutis congenita over the scalp vertex", "Aplasia hypoplasia affecting bones of the axial skeleton", "Aplasia hypoplasia affecting the anterior segment of the eye", "Aplasia hypoplasia affecting the eye", "Aplasia hypoplasia affecting the fundus", "Aplasia hypoplasia involving bones of the feet", "Aplasia hypoplasia involving bones of the lower limbs", "Aplasia hypoplasia involving bones of the thorax", "Aplasia hypoplasia involving bones of the upper limbs", "Aplasia hypoplasia involving forearm bones", "Aplasia hypoplasia involving the carpal bones", "Aplasia hypoplasia involving the femoral head and neck", "Aplasia hypoplasia involving the metacarpal bones", "Aplasia hypoplasia involving the musculature of the upper limbs", "Aplasia hypoplasia involving the nose", "Aplasia hypoplasia involving the pelvis", "Aplasia hypoplasia involving the sinuses", "Aplasia hypoplasia involving the skeletal musculature", "Aplasia hypoplasia involving the skeleton", "Aplasia hypoplasia involving the vertebral column", "Aplasia hypoplasia of fingers", "Aplasia hypoplasia of metatarsal bones", "Aplasia hypoplasia of the 4th metacarpal", "Aplasia hypoplasia of the 5th finger", "Aplasia hypoplasia of the 5th metacarpal", "Aplasia hypoplasia of the abdominal wall musculature", "Aplasia hypoplasia of the bladder", "Aplasia hypoplasia of the breasts", "Aplasia hypoplasia of the capital femoral epiphysis", "Aplasia hypoplasia of the cerebellar vermis", "Aplasia hypoplasia of the cerebellum", "Aplasia hypoplasia of the cerebral white matter", "Aplasia hypoplasia of the clavicles", "Aplasia hypoplasia of the colon", "Aplasia hypoplasia of the distal phalanges of the hand", "Aplasia hypoplasia of the distal phalanx of the thumb", "Aplasia hypoplasia of the ear", "Aplasia hypoplasia of the earlobes", "Aplasia hypoplasia of the epiglottis", "Aplasia hypoplasia of the extremities", "Aplasia hypoplasia of the eyebrow", "Aplasia hypoplasia of the eyelid", "Aplasia hypoplasia of the femur", "Aplasia hypoplasia of the fibula", "Aplasia hypoplasia of the gallbladder", "Aplasia hypoplasia of the hallux", "Aplasia hypoplasia of the humerus", "Aplasia hypoplasia of the lungs", "Aplasia hypoplasia of the middle phalanges of the toes", "Aplasia hypoplasia of the nails", "Aplasia hypoplasia of the nasal bone", "Aplasia hypoplasia of the nasal septum", "Aplasia hypoplasia of the nipples", "Aplasia hypoplasia of the optic nerve", "Aplasia hypoplasia of the ovary", "Aplasia hypoplasia of the palmar creases", "Aplasia hypoplasia of the patella", "Aplasia hypoplasia of the phalanges of the hand", "Aplasia hypoplasia of the phalanges of the thumb", "Aplasia hypoplasia of the phalanges of the toes", "Aplasia hypoplasia of the proximal phalanges of the hand", "Aplasia hypoplasia of the pubic bone", "Aplasia hypoplasia of the radius", "Aplasia hypoplasia of the retina", "Aplasia hypoplasia of the ribs", "Aplasia hypoplasia of the sacrum", "Aplasia hypoplasia of the scapulae", "Aplasia hypoplasia of the skin", "Aplasia hypoplasia of the spleen", "Aplasia hypoplasia of the sternum", "Aplasia hypoplasia of the thumb", "Aplasia hypoplasia of the thymus", "Aplasia hypoplasia of the thyroid gland", "Aplasia hypoplasia of the tibia", "Aplasia hypoplasia of the tongue", "Aplasia hypoplasia of the tragus", "Aplasia hypoplasia of the ulna", "Aplasia hypoplasia of the uterus", "Aplasia hypoplasia of the uvula", "Aplasia hypoplasia of the vagina", "Aplasia hypoplasia of toe", "Aplasia involving bones of the extremities", "Aplasia involving bones of the lower limbs", "Aplasia of metacarpal bones", "Aplasia of the fingers", "Aplasia of the middle phalanx of the hand", "Aplasia of the phalanges of the hand", "Aplasia of the phalanges of the toes", "Aplasia of the proximal phalanges of the hand", "Aplasia of the semicircular canal", "Aplasia of the uterus", "Aplastic anemia", "Aplastic clavicle", "Aplastic hypoplastic lacrimal glands", "Aplastic hypoplastic toenail", "Apnea", "Apneic episodes in infancy", "Apneic episodes precipitated by illness fatigue stress", "Appendicular hypotonia", "Apraxia", "Aqueductal stenosis", "Arachnodactyly", "Arachnoid hemangiomatosis", "Areflexia", "Areflexia of lower limbs", "Arm dystonia", "Arnold chiari malformation", "Arnold chiari type i malformation", "Arrhinencephaly", "Arteria lusoria", "Arterial dissection", "Arterial rupture", "Arterial stenosis", "Arterial thrombosis", "Arteriosclerosis", "Arteriovenous malformation", "Arthralgia", "Arthritis", "Arthrogryposis multiplex congenita", "Arthropathy", "Ascending aortic dissection", "Ascending tubular aorta aneurysm", "Ascites", "Aspiration", "Aspiration pneumonia", "Asterixis", "Asthenia", "Asthma", "Astigmatism", "Astrocytoma", "Astrocytosis", "Asymmetric growth", "Asymmetric septal hypertrophy", "Asymmetry of the ears", "Atelectasis", "Athetosis", "Atlantoaxial abnormality", "Atlantoaxial dislocation", "Atonic seizure", "Atopic dermatitis", "Atresia of the external auditory canal", "Atrial arrhythmia", "Atrial flutter", "Atrioventricular canal defect", "Atrophic scars", "Atrophy degeneration affecting the brainstem", "Atrophy degeneration affecting the central nervous system", "Atrophy degeneration affecting the cerebrum", "Atrophy degeneration involving the caudate nucleus", "Atrophy degeneration involving the corticospinal tracts", "Atrophy degeneration involving the spinal cord", "Atrophy of alveolar ridges", "Attention deficit hyperactivity disorder", "Attenuation of retinal blood vessels", "Atypical absence seizure", "Auditory hallucinations", "Autism", "Autistic behavior", "Autoamputation", "Autoamputation of digits", "Autoimmune antibody positivity", "Autoimmune hemolytic anemia", "Autoimmune thrombocytopenia", "Autoimmunity", "Autophagic vacuoles", "Autosomal dominant germline de novo mutation", "Avascular necrosis", "Avascular necrosis of the capital femoral epiphysis", "Axial dystonia", "Axial muscle weakness", "Axillary pterygium", "Axonal degeneration", "Axonal degeneration regeneration", "Axonal loss", "Axonal regeneration", "Azoospermia", "B cell lymphoma", "B lymphocytopenia", "Babinski sign", "Back pain", "Bacterial endocarditis", "Barrel shaped chest", "Barrett esophagus", "Basal cell carcinoma", "Basal ganglia calcification", "Basal ganglia cysts", "Basal ganglia gliosis", "Basilar invagination", "Beaded ribs", "Beaking of vertebral bodies", "Bell shaped thorax", "Benign neoplasm of the central nervous system", "Bicarbonaturia", "Biconcave vertebral bodies", "Bicornuate uterus", "Bifid nasal tip", "Bifid nose", "Bifid ribs", "Bifid scrotum", "Bifid tongue", "Bifid uterus", "Bifid uvula", "Bilateral camptodactyly", "Bilateral cleft lip", "Bilateral cleft lip and palate", "Bilateral cleft palate", "Bilateral coxa valga", "Bilateral cryptorchidism", "Bilateral external ear deformity", "Bilateral microphthalmos", "Bilateral polymicrogyria", "Bilateral ptosis", "Bilateral sensorineural hearing impairment", "Bilateral single transverse palmar creases", "Bilateral talipes equinovarus", "Bilateral tonic clonic seizure", "Bilateral tonic clonic seizure with focal onset", "Bilateral tonic clonic seizure with generalized onset", "Bile duct proliferation", "Biliary atresia", "Biliary cirrhosis", "Biliary tract abnormality", "Biliary tract neoplasm", "Bimanual synkinesia", "Biparietal narrowing", "Bird like facies", "Birth length greater than 97th percentile", "Birth length less than 3rd percentile", "Biventricular hypertrophy", "Bladder diverticulum", "Bladder neoplasm", "Bleeding with minor or no trauma", "Blepharitis", "Blepharophimosis", "Blindness", "Blistering by anatomical location", "Blistering by histological location", "Bloodstream infectious agent", "Bloody diarrhea", "Blue irides", "Blue nevus", "Blue sclerae", "Blurred vision", "Bone cyst", "Bone fracture", "Bone marrow foam cells", "Bone marrow hypercellularity", "Bone marrow hypocellularity", "Bone pain", "Bone spicule pigmentation of the retina", "Bowel diverticulosis", "Bowing of the arm", "Bowing of the legs", "Brachycephaly", "Brachydactyly", "Bradycardia", "Bradykinesia", "Brain imaging abnormality", "Brain neoplasm", "Brain stem compression", "Branchial anomaly", "Branchial cyst", "Branchial fistula", "Breast aplasia", "Breast carcinoma", "Breast hypoplasia", "Breathing dysregulation", "Breech presentation", "Brisk reflexes", "Brittle hair", "Broad alveolar ridges", "Broad based gait", "Broad chin", "Broad columella", "Broad distal phalanx of finger", "Broad eyebrow", "Broad face", "Broad femoral neck", "Broad finger", "Broad foot", "Broad forehead", "Broad hallux phalanx", "Broad jaw", "Broad long bones", "Broad metacarpals", "Broad nasal tip", "Broad neck", "Broad palm", "Broad phalanx of the toes", "Broad philtrum", "Broad ribs", "Broad thumb", "Broad toe", "Bronchiectasis", "Bronchitis", "Bronchomalacia", "Bronchospasm", "Bruising susceptibility", "Brushfield spots", "Bruxism", "Bulbar palsy", "Bulbar signs", "Bulbous nose", "Bull s eye maculopathy", "Bundle branch block", "Buphthalmos", "Burkitt lymphoma", "Butterfly vertebrae", "Cachexia", "Caesarian section", "Cafe au lait spot", "Calcific stippling", "Calcification of the aorta", "Calcinosis", "Calcium nephrolithiasis", "Calcium oxalate nephrolithiasis", "Calvarial hyperostosis", "Calvarial osteosclerosis", "Calvarial skull defect", "Camptodactyly of toe", "Capillary hemangioma", "Capillary malformation", "Capitate hamate fusion", "Carcinoid tumor", "Carcinoma", "Cardiac arrest", "Cardiac conduction abnormality", "Cardiac diverticulum", "Cardiac shunt", "Cardiac valve calcification", "Cardiomegaly", "Cardiorespiratory arrest", "Cardiovascular calcification", "Carious teeth", "Carpal bone hypoplasia", "Carpal synostosis", "Cataplexy", "Caudate atrophy", "Cavernous hemangioma", "Cavum septum pellucidum", "Celiac disease", "Cellular immunodeficiency", "Cellulitis", "Central adrenal insufficiency", "Central apnea", "Central diabetes insipidus", "Central hypothyroidism", "Central hypoventilation", "Central nervous system cyst", "Central primitive neuroectodermal tumor", "Central scotoma", "Central sleep apnea", "Central y shaped metacarpal", "Centrally nucleated skeletal muscle fibers", "Centrocecal scotoma", "Cerebellar atrophy", "Cerebellar cortical atrophy", "Cerebellar cyst", "Cerebellar dysplasia", "Cerebellar hemorrhage", "Cerebellar hypoplasia", "Cerebellar malformation", "Cerebellar vermis atrophy", "Cerebral amyloid angiopathy", "Cerebral calcification", "Cerebral cortical atrophy", "Cerebral cortical hemiatrophy", "Cerebral dysmyelination", "Cerebral edema", "Cerebral hamartoma", "Cerebral hemorrhage", "Cerebral hypomyelination", "Cerebral hypoplasia", "Cerebral inclusion bodies", "Cerebral palsy", "Cerebral venous thrombosis", "Cerebral visual impairment", "Cerebral white matter atrophy", "Cerebral white matter hypoplasia", "Cervical kyphosis", "Cervical myelopathy", "Cervical ribs", "Cervical spinal canal stenosis", "Cervical spine instability", "Cervical subluxation", "Cessation of head growth", "Cheilitis", "Cherry red spot of the macula", "Chest pain", "Chilblains", "Childhood onset", "Childhood onset sensorineural hearing impairment", "Childhood onset truncal obesity", "Chills", "Choanal stenosis", "Choking episodes", "Cholangitis", "Cholecystitis", "Cholestasis", "Cholestatic liver disease", "Chondrocalcinosis", "Chondrosarcoma", "Chordee", "Chorea", "Choreoathetosis", "Choriocarcinoma", "Chorioretinal atrophy", "Chorioretinal coloboma", "Chorioretinal degeneration", "Chorioretinal dysplasia", "Chorioretinal hypopigmentation", "Choroid plexus carcinoma", "Choroid plexus cyst", "Choroidal melanoma", "Choroidal neovascularization", "Chromosomal breakage induced by crosslinking agents", "Chromosomal breakage induced by ionizing radiation", "Chromosome breakage", "Chronic atrophic gastritis", "Chronic axonal neuropathy", "Chronic bronchitis", "Chronic constipation", "Chronic diarrhea", "Chronic fatigue", "Chronic hemolytic anemia", "Chronic hepatic failure", "Chronic infection", "Chronic kidney disease", "Chronic leukemia", "Chronic lung disease", "Chronic lymphatic leukemia", "Chronic mucocutaneous candidiasis", "Chronic neutropenia", "Chronic noninfectious lymphadenopathy", "Chronic oral candidiasis", "Chronic otitis media", "Chronic pulmonary obstruction", "Chronic rhinitis", "Chronic sinusitis", "Chylothorax", "Cigarette paper scars", "Cirrhosis", "Cleft hard palate", "Cleft lip", "Cleft soft palate", "Cleft upper lip", "Clinodactyly", "Clinodactyly of the 5th toe", "Clitoral hypoplasia", "Clonic seizure", "Clonus", "Cloverleaf skull", "Clubbing", "Clubbing of fingers", "Clubbing of toes", "Clumsiness", "Cns demyelination", "Cns hypomyelination", "Coarctation of aorta", "Coarse facial features", "Coarse hair", "Cochlear malformation", "Cognitive impairment", "Cogwheel rigidity", "Cold induced muscle cramps", "Colitis", "Collectionism", "Coloboma", "Colon cancer", "Color vision defect", "Color vision test abnormality", "Colorectal polyposis", "Colpocephaly", "Coma", "Combined immunodeficiency", "Communicating hydrocephalus", "Complete atrioventricular canal defect", "Complete duplication of phalanx of hand", "Complex febrile seizure", "Concave nail", "Concave nasal ridge", "Concentric hypertrophic cardiomyopathy", "Cone cone rod dystrophy", "Cone shaped epiphyses of the phalanges of the hand", "Cone shaped epiphysis", "Confetti like hypopigmented macules", "Confusion", "Congenital adrenal hyperplasia", "Congenital bilateral hip dislocation", "Congenital blindness", "Congenital contracture", "Congenital craniofacial dysostosis", "Congenital diaphragmatic hernia", "Congenital finger flexion contractures", "Congenital hemolytic anemia", "Congenital hepatic fibrosis", "Congenital hip dislocation", "Congenital hypothyroidism", "Congenital ichthyosiform erythroderma", "Congenital localized absence of skin", "Congenital malformation of the great arteries", "Congenital malformation of the left heart", "Congenital malformation of the right heart", "Congenital muscular dystrophy", "Congenital muscular torticollis", "Congenital nonbullous ichthyosiform erythroderma", "Congenital nystagmus", "Congenital onset", "Congenital posterior urethral valve", "Congenital sensorineural hearing impairment", "Congenital stationary night blindness", "Congenital thrombocytopenia", "Congestive heart failure", "Conical tooth", "Conjugated hyperbilirubinemia", "Conjunctival hamartoma", "Connective tissue nevi", "Conspicuously happy disposition", "Constipation", "Constitutional symptom", "Constriction of peripheral visual field", "Contiguous gene syndrome", "Contractures involving the joints of the feet", "Contractures of the joints of the lower limbs", "Contractures of the joints of the upper limbs", "Contractures of the large joints", "Convex nasal ridge", "Coombs positive hemolytic anemia", "Cor pulmonale", "Corneal dystrophy", "Corneal erosion", "Corneal neovascularization", "Corneal opacity", "Corneal scarring", "Corneal ulceration", "Coronal cleft vertebrae", "Coronal craniosynostosis", "Coronary artery atherosclerosis", "Corpus callosum atrophy", "Cortical cataract", "Cortical dysplasia", "Cortical myoclonus", "Cortical thickening of long bone diaphyses", "Corticospinal tract hypoplasia", "Cough", "Coxa valga", "Coxa vara", "Crackles", "Cranial asymmetry", "Cranial hyperostosis", "Cranial nerve compression", "Craniofacial asymmetry", "Craniofacial dysostosis", "Craniofacial hyperostosis", "Craniofacial osteosclerosis", "Craniosynostosis", "Crumpled long bones", "Cryptorchidism", "Csf lymphocytic pleiocytosis", "Csf pleocytosis", "Cubitus valgus", "Cupped ear", "Cupped ribs", "Curly eyelashes", "Curly hair", "Cutaneous abscess", "Cutaneous amyloidosis", "Cutaneous cyst", "Cutaneous finger syndactyly", "Cutaneous melanoma", "Cutaneous photosensitivity", "Cutaneous syndactyly", "Cutaneous syndactyly of toes", "Cutis laxa", "Cutis marmorata", "Cyanosis", "Cyanotic episode", "Cyclopia", "Cystic hygroma", "Cystic liver disease", "Cystic renal dysplasia", "Cystinuria", "Cystoid macular edema", "Cytochrome c oxidase negative muscle fibers", "Dark urine", "Death in adolescence", "Death in adulthood", "Death in childhood", "Death in infancy", "Decerebrate rigidity", "Decreased absent ankle reflexes", "Decreased achilles reflex", "Decreased activity of mitochondrial complex i", "Decreased activity of mitochondrial complex ii", "Decreased activity of mitochondrial complex iii", "Decreased activity of mitochondrial complex iv", "Decreased activity of the pyruvate dehydrogenase complex", "Decreased adenosylcobalamin", "Decreased adipose tissue", "Decreased calvarial ossification", "Decreased cd4 cd8 ratio", "Decreased cervical spine flexion due to contractures of posterior cervical muscles", "Decreased circulating acth level", "Decreased circulating aldosterone level", "Decreased circulating androgen concentration", "Decreased circulating antibody level", "Decreased circulating copper concentration", "Decreased circulating cortisol level", "Decreased circulating follicle stimulating hormone concentration", "Decreased circulating gonadotropin concentration", "Decreased circulating iga level", "Decreased circulating igg level", "Decreased circulating igg subclass level", "Decreased circulating level of specific antibody", "Decreased circulating progesterone", "Decreased circulating total iga", "Decreased circulating total igg", "Decreased circulating total igm", "Decreased corneal reflex", "Decreased facial expression", "Decreased fertility", "Decreased fertility in females", "Decreased fertility in males", "Decreased head circumference", "Decreased lacrimation", "Decreased ldl cholesterol concentration", "Decreased libido", "Decreased light and dark adapted electroretinogram amplitude", "Decreased lymphocyte apoptosis", "Decreased lymphocyte proliferation in response to mitogen", "Decreased mean corpuscular volume", "Decreased methylcobalamin", "Decreased methylmalonyl coa mutase activity", "Decreased muscle mass", "Decreased number of large peripheral myelinated nerve fibers", "Decreased number of peripheral myelinated nerve fibers", "Decreased patellar reflex", "Decreased plasma carnitine", "Decreased proportion of cd3 positive t cells", "Decreased proportion of cd4 positive helper t cells", "Decreased pulmonary function", "Decreased serum complement c3", "Decreased serum insulin like growth factor 1", "Decreased serum iron", "Decreased size of nerve terminals", "Decreased specific anti polysaccharide antibody level", "Decreased specific antibody response to protein vaccine", "Decreased specific antibody response to vaccination", "Decreased specific pneumococcal antibody level", "Decreased testicular size", "Decreased urine output", "Deep palmar crease", "Deep philtrum", "Deep plantar creases", "Deep set nails", "Deep venous thrombosis", "Deeply set eye", "Defective dna repair after ultraviolet radiation damage", "Defective t cell proliferation", "Deformed rib cage", "Deformed sella turcica", "Deformed tarsal bones", "Degeneration of the lateral corticospinal tracts", "Degeneration of the striatum", "Dehydration", "Delayed ability to roll over", "Delayed ability to sit", "Delayed ability to stand", "Delayed ability to walk", "Delayed closure of the anterior fontanelle", "Delayed cns myelination", "Delayed cranial suture closure", "Delayed epiphyseal ossification", "Delayed eruption of permanent teeth", "Delayed eruption of primary teeth", "Delayed eruption of teeth", "Delayed fine motor development", "Delayed gross motor development", "Delayed menarche", "Delayed myelination", "Delayed ossification of carpal bones", "Delayed proximal femoral epiphyseal ossification", "Delayed puberty", "Delayed social development", "Delirium", "Delusions", "Dementia", "Demyelinating peripheral neuropathy", "Dental crowding", "Dental malocclusion", "Depletion of mitochondrial dna in muscle tissue", "Deposits immunoreactive to beta amyloid protein", "Depressed nasal bridge", "Depressed nasal ridge", "Depressed nasal tip", "Depression", "Dermal atrophy", "Dermal translucency", "Dermatological manifestations of systemic disorders", "Descending aortic dissection", "Desquamation of skin soon after birth", "Developmental cataract", "Developmental glaucoma", "Developmental regression", "Developmental stagnation", "Deviated nasal septum", "Deviation of the 2nd finger", "Deviation of the 3rd finger", "Deviation of the 5th toe", "Deviation of the hallux", "Deviation of the hand or of fingers of the hand", "Deviation of the thumb", "Deviation of toes", "Diabetes insipidus", "Dialeptic seizure", "Diaphragmatic eventration", "Diaphragmatic paralysis", "Diaphragmatic weakness", "Diaphyseal sclerosis", "Diaphyseal thickening", "Diarrhea", "Diastasis recti", "Diastema", "Dicarboxylic aciduria", "Difficulty climbing stairs", "Difficulty in tongue movements", "Difficulty running", "Difficulty standing", "Difficulty walking", "Diffuse alveolar hemorrhage", "Diffuse cerebellar atrophy", "Diffuse cerebral atrophy", "Diffuse mesangial sclerosis", "Diffuse optic disc pallor", "Diffuse palmoplantar hyperkeratosis", "Diffuse white matter abnormalities", "Digenic inheritance", "Dilatation of the cerebral artery", "Dilatation of the ventricular cavity", "Dilated cardiomyopathy", "Dilated fourth ventricle", "Dilated third ventricle", "Dilation of lateral ventricles", "Dilation of virchow robin spaces", "Diminished ability to concentrate", "Diminished motivation", "Diminished movement", "Dimple chin", "Diplopia", "Disinhibition", "Displacement of the urethral meatus", "Disproportionate short limb short stature", "Disproportionate short stature", "Disproportionate short trunk short stature", "Disproportionate tall stature", "Disseminated intravascular coagulation", "Distal amyotrophy", "Distal arthrogryposis", "Distal joint laxity", "Distal lower limb amyotrophy", "Distal lower limb muscle weakness", "Distal muscle weakness", "Distal peripheral sensory neuropathy", "Distal sensory impairment", "Distal sensory impairment of all modalities", "Distal sensory loss of all modalities", "Distal upper limb amyotrophy", "Distal upper limb muscle weakness", "Disturbance of facial expression", "Dolichocephaly", "Double aortic arch", "Down sloping shoulders", "Downslanted palpebral fissures", "Downturned corners of mouth", "Drowsiness", "Drusen", "Dry hair", "Dry skin", "Duodenal adenocarcinoma", "Duodenal atresia", "Duodenal stenosis", "Duplicated collecting system", "Duplication involving bones of the feet", "Duplication of hand bones", "Duplication of phalanx of hallux", "Duplication of the distal phalanx of hand", "Duplication of thumb phalanx", "Dysarthria", "Dyscalculia", "Dyschromatopsia", "Dysdiadochokinesis", "Dysesthesia", "Dysgenesis of the cerebellar vermis", "Dysgerminoma", "Dysgraphia", "Dyskinesia", "Dyslexia", "Dysmenorrhea", "Dysmetria", "Dysmetric saccades", "Dysostosis multiplex", "Dyspareunia", "Dysphagia", "Dysphasia", "Dysphonia", "Dysplasia of the femoral head", "Dysplastic corpus callosum", "Dyspnea", "Dystonia", "Dystrophic fingernails", "Dystrophic toenail", "Dysuria", "Ear pain", "Early onset absence seizures", "Early onset of sexual maturation", "Easy fatigability", "Ecchymosis", "Echolalia", "Eclabion", "Eclampsia", "Ectodermal dysplasia", "Ectopia lentis", "Ectopia pupillae", "Ectopic anus", "Ectopic calcification", "Ectopic kidney", "Ectrodactyly", "Ectropion", "Ectropion of lower eyelids", "Eczema", "Eczematoid dermatitis", "Edema of the dorsum of feet", "Edema of the dorsum of hands", "Eeg with abnormally slow frequencies", "Eeg with burst suppression", "Eeg with continuous slow activity", "Eeg with focal epileptiform discharges", "Eeg with focal sharp waves", "Eeg with focal spike waves", "Eeg with focal spikes", "Eeg with frontal epileptiform discharges", "Eeg with generalized sharp slow waves", "Eeg with generalized slow activity", "Eeg with irregular generalized spike and wave complexes", "Eeg with multifocal slow activity", "Eeg with polyspike wave complexes", "Eeg with spike wave complexes", "Eeg with spike wave complexes 2 5 3 5 hz", "Elbow ankylosis", "Elbow flexion contracture", "Elevated alkaline phosphatase of bone origin", "Elevated calcitonin", "Elevated circulating alanine aminotransferase concentration", "Elevated circulating aspartate aminotransferase concentration", "Elevated circulating follicle stimulating hormone level", "Elevated circulating glutaric acid concentration", "Elevated circulating growth hormone concentration", "Elevated circulating long chain fatty acid concentration", "Elevated circulating parathyroid hormone level", "Elevated circulating thyroid stimulating hormone concentration", "Elevated creatine kinase after exercise", "Elevated diastolic blood pressure", "Elevated gamma glutamyltransferase level", "Elevated hemoglobin a1c", "Elevated hepatic transaminase", "Elevated lactate pyruvate ratio", "Elevated mean arterial pressure", "Elevated proportion of cd4 negative cd8 negative alpha beta regulatory t cells", "Elevated pulmonary artery pressure", "Elevated serum acid phosphatase", "Elevated systolic blood pressure", "Elevated tissue non specific alkaline phosphatase", "Elevated urinary carboxylic acid", "Elevated urinary delta aminolevulinic acid", "Elevated urinary dicarboxylic acid level", "Elevated urinary monocarboxylic acid level", "Elfin facies", "Elliptocytosis", "Elongated superior cerebellar peduncle", "Embryonal neoplasm", "Embryonal renal neoplasm", "Emg abnormality", "Emg axonal abnormality", "Emg chronic denervation signs", "Emg decremental response of compound muscle action potential to repetitive nerve stimulation", "Emg impaired neuromuscular transmission", "Emg myopathic abnormalities", "Emg neuropathic changes", "Emg slow motor conduction", "Emotional lability", "Emphysema", "Enamel hypoplasia", "Encephalocele", "Encephalopathy", "Enchondroma", "Endocardial fibrosis", "Endocarditis", "Enlarged cerebellum", "Enlarged cisterna magna", "Enlarged epiphyses", "Enlarged joints", "Enlarged kidney", "Enlarged metaphyses", "Enlarged ovaries", "Enlarged posterior fossa", "Enlarged thorax", "Enlarged tonsils", "Enlargement of the costochondral junction", "Enlargement of the wrists", "Enterocolitis", "Enthesitis", "Entropion", "Enuresis", "Ependymoma", "Epicanthus", "Epicanthus inversus", "Epidermal acanthosis", "Epidermal hyperkeratosis", "Epidermal nevus", "Epidermoid cyst", "Epigastric pain", "Epileptic aura", "Epileptic encephalopathy", "Epileptic spasm", "Epiphora", "Epiphyseal dysplasia", "Epiphyseal stippling", "Epiretinal membrane", "Episodic ataxia", "Episodic hyperhidrosis", "Episodic hypertension", "Episodic pain", "Episodic respiratory distress", "Episodic tachypnea", "Episodic vomiting", "Epispadias", "Epistaxis", "Equinovarus deformity", "Equinus calcaneus", "Erectile dysfunction", "Erlenmeyer flask deformity of the femurs", "Eruption failure", "Erysipelas", "Erythema", "Erythema nodosum", "Erythematous plaque", "Erythrocyte inclusion bodies", "Erythroderma", "Erythroid hyperplasia", "Erythroid hypoplasia", "Esodeviation", "Esophageal atresia", "Esophageal carcinoma", "Esophageal neoplasm", "Esophageal stenosis", "Esophageal stricture", "Esophageal ulceration", "Esophageal varix", "Esophagitis", "Ethylmalonic aciduria", "Eunuchoid habitus", "Euryblepharon", "Eversion of lateral third of lower eyelids", "Everted upper lip vermilion", "Exaggerated cupid s bow", "Exaggerated startle response", "Excessive daytime somnolence", "Excessive salivation", "Excessive wrinkled skin", "Excessive wrinkling of palmar skin", "Exercise induced muscle cramps", "Exercise induced muscle fatigue", "Exercise induced muscle stiffness", "Exercise induced myalgia", "Exercise induced myoglobinuria", "Exercise induced rhabdomyolysis", "Exercise intolerance", "Exertional dyspnea", "Exodeviation", "Exostoses", "Expressive aphasia", "Expressive language delay", "External ear malformation", "External genital hypoplasia", "External ophthalmoplegia", "Extra axial cerebrospinal fluid accumulation", "Extrahepatic cholestasis", "Extramedullary hematopoiesis", "Extrapyramidal dyskinesia", "Extrapyramidal muscular rigidity", "Exudative retinal detachment", "Eyelid coloboma", "Eyelid myoclonus", "Facial asymmetry", "Facial capillary hemangioma", "Facial cleft", "Facial diplegia", "Facial edema", "Facial erythema", "Facial grimacing", "Facial hemangioma", "Facial hypertrichosis", "Facial hypotonia", "Facial shape deformation", "Facial telangiectasia", "Failure of eruption of permanent teeth", "Failure to thrive", "Failure to thrive in infancy", "Fair hair", "Falls", "Fasciculations", "Fasting hyperinsulinemia", "Fasting hypoglycemia", "Fat malabsorption", "Fatigable weakness of bulbar muscles", "Fatigable weakness of distal limb muscles", "Fatigable weakness of respiratory muscles", "Fatigable weakness of skeletal muscles", "Fatigable weakness of swallowing muscles", "Fatiguable weakness of proximal limb muscles", "Fatigue", "Fatty replacement of skeletal muscle", "Feeding difficulties", "Feeding difficulties in infancy", "Female external genitalia in individual with 46 xy karyotype", "Female hypogonadism", "Female infertility", "Female pseudohermaphroditism", "Female reproductive system neoplasm", "Female sexual dysfunction", "Femoral bowing", "Femoral hernia", "Fetal akinesia sequence", "Fetal distress", "Fetal onset", "Fetal polyuria", "Fetal ultrasound soft marker", "Fever", "Fibroadenoma of the breast", "Fibrosarcoma", "Fibrous tissue neoplasm", "Fibular aplasia", "Fibular hypoplasia", "Fine hair", "Finger agnosia", "Finger clinodactyly", "Finger swelling", "Finger syndactyly", "Fingernail dysplasia", "Fingerprint intracellular accumulation of autofluorescent lipopigment storage material", "First degree atrioventricular block", "First dorsal interossei muscle weakness", "Flank pain", "Flared iliac wing", "Flared metaphysis", "Flared nostrils", "Flaring of rib cage", "Flat acetabular roof", "Flat cornea", "Flat face", "Flat forehead", "Flat nasal alae", "Flat occiput", "Flattened epiphysis", "Flattened femoral epiphysis", "Flattened femoral head", "Flexion contracture of digit", "Flexion contracture of thumb", "Fluctuations in consciousness", "Flushing", "Foam cells", "Focal aware seizure", "Focal cortical dysplasia", "Focal cortical dysplasia type ii", "Focal dystonia", "Focal emotional seizure", "Focal impaired awareness seizure", "Focal motor seizure", "Focal motor status epilepticus", "Focal myoclonic seizure", "Focal non motor seizure", "Focal onset seizure", "Focal segmental glomerulosclerosis", "Focal sensory seizure", "Focal t2 hyperintense basal ganglia lesion", "Focal t2 hyperintense brainstem lesion", "Focal tonic seizure", "Focal white matter lesions", "Follicular hyperkeratosis", "Follicular hyperplasia", "Follicular thyroid carcinoma", "Food allergy", "Food intolerance", "Foot acroosteolysis", "Foot dorsiflexor weakness", "Foot oligodactyly", "Fractures of the long bones", "Fragile nails", "Fragile skin", "Fragmented epiphyses", "Freckling", "Frequent falls", "Frontal balding", "Frontal cortical atrophy", "Frontal hirsutism", "Frontal lobe dementia", "Frontotemporal cerebral atrophy", "Frontotemporal dementia", "Full cheeks", "Fulminant hepatic failure", "Functional abnormality of male internal genitalia", "Functional abnormality of the gastrointestinal tract", "Functional abnormality of the inner ear", "Functional abnormality of the middle ear", "Functional intestinal obstruction", "Functional motor deficit", "Furrowed tongue", "Fused cervical vertebrae", "Gait ataxia", "Gait disturbance", "Gait imbalance", "Galactorrhea", "Ganglioneuroblastoma", "Ganglioneuroma", "Gangrene", "Gastric ulcer", "Gastritis", "Gastroesophageal reflux", "Gastrointestinal atresia", "Gastrointestinal carcinoma", "Gastrointestinal hemorrhage", "Gastrointestinal infarctions", "Gastrointestinal inflammation", "Gastrointestinal obstruction", "Gastrointestinal stroma tumor", "Gastroparesis", "Gastrostomy tube feeding in infancy", "Gaze evoked nystagmus", "Generalized abnormality of skin", "Generalized aminoaciduria", "Generalized amyotrophy", "Generalized clonic seizure", "Generalized dystonia", "Generalized edema", "Generalized hirsutism", "Generalized hyperkeratosis", "Generalized hyperpigmentation", "Generalized hyperreflexia", "Generalized hypertrichosis", "Generalized hypopigmentation", "Generalized hypopigmentation of hair", "Generalized hypotonia", "Generalized joint laxity", "Generalized limb muscle atrophy", "Generalized lipodystrophy", "Generalized lymphadenopathy", "Generalized muscle weakness", "Generalized myoclonic atonic seizure", "Generalized myoclonic seizure", "Generalized neonatal hypotonia", "Generalized onset motor seizure", "Generalized onset seizure", "Generalized osteoporosis", "Generalized osteosclerosis", "Generalized tonic seizure", "Genetic anticipation", "Genital neoplasm", "Genu valgum", "Genu varum", "Germ cell neoplasia", "Germinoma", "Giant platelets", "Giant somatosensory evoked potentials", "Gingival bleeding", "Gingival fibromatosis", "Gingival overgrowth", "Gingival recession", "Gingivitis", "Glaucoma", "Glioblastoma multiforme", "Glioma", "Gliosis", "Global brain atrophy", "Glomerular deposits", "Glomerular sclerosis", "Glomerulonephritis", "Glomerulopathy", "Glomus jugular tumor", "Glossitis", "Glossoptosis", "Glucose intolerance", "Glutaric aciduria", "Glycosuria", "Goiter", "Gonadal dysgenesis", "Gonadal neoplasm", "Gonadoblastoma", "Gonadotropin deficiency", "Gonosomal inheritance", "Gout", "Gowers sign", "Grammar specific speech disorder", "Granulocytopenia", "Granulomatosis", "Gray matter heterotopia", "Gynecomastia", "Halitosis", "Hallucinations", "Hallux valgus", "Hamartoma", "Hamartoma of the eye", "Hamartoma of tongue", "Hamartomatous polyposis", "Hammertoe", "Hamstring contractures", "Hand apraxia", "Hand clenching", "Hand muscle weakness", "Hand oligodactyly", "Hand polydactyly", "Hand tremor", "Handgrip myotonia", "Happy demeanor", "Hashimoto thyroiditis", "Head banging", "Head titubation", "Head tremor", "Headache", "Heart block", "Heat intolerance", "Heinz bodies", "Helicobacter pylori infection", "Hemangioblastoma", "Hemangiomatosis", "Hematological neoplasm", "Hemianopia", "Hemiatrophy", "Hemifacial spasm", "Hemihypertrophy", "Hemimegalencephaly", "Hemiparesis", "Hemiplegia hemiparesis", "Hemivertebrae", "Hemoglobinuria", "Hemolytic anemia", "Hemoptysis", "Hemorrhage of the eye", "Heparan sulfate excretion in urine", "Hepatic cysts", "Hepatic encephalopathy", "Hepatic failure", "Hepatic fibrosis", "Hepatic necrosis", "Hepatitis", "Hepatoblastoma", "Hepatocellular adenoma", "Hepatocellular carcinoma", "Hepatomegaly", "Hepatosplenomegaly", "Hereditary nonpolyposis colorectal carcinoma", "Hernia", "Herpes simplex encephalitis", "Heterochromia iridis", "Heterogeneous", "Heteronymous hemianopia", "Heterophoria", "Heterotaxy", "Heterotropia", "Hiatus hernia", "High anterior hairline", "High forehead", "High frequency hearing impairment", "High frequency sensorineural hearing impairment", "High hypermetropia", "High myopia", "High narrow palate", "High palate", "High pitched voice", "Highly arched eyebrow", "Hip contracture", "Hip dislocation", "Hip dysplasia", "Hip flexor weakness", "Hip osteoarthritis", "Hip pain", "Hip subluxation", "Hirsutism", "Hoarse cry", "Hoarse voice", "Hodgkin lymphoma", "Holoprosencephaly", "Homocystinuria", "Honeycomb lung", "Horizontal eyebrow", "Horizontal nystagmus", "Horizontal pendular nystagmus", "Horizontal ribs", "Horseshoe kidney", "Humeroradial synostosis", "Hydranencephaly", "Hydrocele testis", "Hydrocephalus", "Hydrops fetalis", "Hydroureter", "Hydroxyprolinuria", "Hyperactive deep tendon reflexes", "Hyperactive patellar reflex", "Hyperactivity", "Hyperacusis", "Hyperaldosteronism", "Hyperammonemia", "Hyperautofluorescent macular lesion", "Hyperautofluorescent retinal lesion", "Hypercalcemia", "Hyperchloremic acidosis", "Hypercholesterolemia", "Hypercoagulability", "Hyperconvex fingernails", "Hyperconvex nail", "Hyperesthesia", "Hyperextensibility at wrists", "Hyperextensibility of the finger joints", "Hyperextensible skin", "Hypergalactosemia", "Hyperglycemia", "Hypergonadotropic hypogonadism", "Hypergranulosis", "Hyperhidrosis", "Hyperhomocystinemia", "Hyperinsulinemic hypoglycemia", "Hyperintensity of cerebral white matter on mri", "Hyperkalemia", "Hyperkeratosis", "Hyperkeratotic papule", "Hyperketonemia", "Hyperkinetic movements", "Hyperlipidemia", "Hyperlipoproteinemia", "Hyperlordosis", "Hypermagnesemia", "Hypermethioninemia", "Hypermetric saccades", "Hypermetropia", "Hypernatriuria", "Hyperorality", "Hyperostosis", "Hyperoxaluria", "Hyperparathyroidism", "Hyperphenylalaninemia", "Hyperphosphatemia", "Hyperphosphaturia", "Hyperpigmentation of the skin", "Hyperpituitarism", "Hyperplasia of the maxilla", "Hyperreflexia", "Hyperreflexia in upper limbs", "Hypersomnia", "Hypersplenism", "Hypertelorism", "Hypertension associated with pheochromocytoma", "Hypertensive crisis", "Hyperthyroidism", "Hypertonia", "Hypertrichosis", "Hypertriglyceridemia", "Hypertrophic cardiomyopathy", "Hypertrophic nerve changes", "Hyperuricemia", "Hyperuricosuria", "Hyperventilation", "Hypoamylasemia", "Hypocalcemia", "Hypocalcemic seizures", "Hypocalcemic tetany", "Hypocalciuria", "Hypochloremia", "Hypocholesterolemia", "Hypochromia", "Hypochromic anemia", "Hypochromic microcytic anemia", "Hypodontia", "Hypoglycemic coma", "Hypoglycemic seizures", "Hypoglycorrhachia", "Hypogonadism", "Hypogonadotropic hypogonadism", "Hypohidrosis", "Hypoinsulinemia", "Hypointensity of cerebral white matter on mri", "Hypokalemia", "Hypokalemic alkalosis", "Hypokalemic metabolic alkalosis", "Hypoketotic hypoglycemia", "Hypokinesia", "Hypolipidemia", "Hypolipoproteinemia", "Hypomethioninemia", "Hypometric saccades", "Hypomimic face", "Hypoparathyroidism", "Hypophosphatemia", "Hypophosphatemic rickets", "Hypopigmentation of the fundus", "Hypopigmentation of the skin", "Hypopigmented macule", "Hypopigmented skin patches", "Hypopituitarism", "Hypoplasia of olfactory tract", "Hypoplasia of penis", "Hypoplasia of teeth", "Hypoplasia of the brainstem", "Hypoplasia of the corpus callosum", "Hypoplasia of the ear cartilage", "Hypoplasia of the epiglottis", "Hypoplasia of the femoral head", "Hypoplasia of the fovea", "Hypoplasia of the frontal lobes", "Hypoplasia of the iris", "Hypoplasia of the musculature", "Hypoplasia of the odontoid process", "Hypoplasia of the olfactory bulb", "Hypoplasia of the pons", "Hypoplasia of the primary teeth", "Hypoplasia of the radius", "Hypoplasia of the uterus", "Hypoplasia of the vagina", "Hypoplasia of the ventral pons", "Hypoplastic anemia", "Hypoplastic aortic arch", "Hypoplastic cervical vertebrae", "Hypoplastic dermoepidermal hemidesmosomes", "Hypoplastic facial bones", "Hypoplastic female external genitalia", "Hypoplastic fifth fingernail", "Hypoplastic fifth toenail", "Hypoplastic fingernail", "Hypoplastic frontal sinuses", "Hypoplastic heart", "Hypoplastic helices", "Hypoplastic ilia", "Hypoplastic ischia", "Hypoplastic labia majora", "Hypoplastic labia minora", "Hypoplastic nipples", "Hypoplastic pelvis", "Hypoplastic pubic rami", "Hypoplastic toenails", "Hypoplastic vertebral bodies", "Hypoproteinemia", "Hyporeflexia", "Hyporeflexia of lower limbs", "Hyporeflexia of upper limbs", "Hyposmia", "Hypotelorism", "Hypotension", "Hypothalamic gonadotropin releasing hormone deficiency", "Hypothalamic hamartoma", "Hypothalamic hypothyroidism", "Hypothermia", "Hypotriglyceridemia", "Hypouricemia", "Hypoventilation", "Hypovolemic shock", "Hypsarrhythmia", "Ichthyosis", "Ileus", "Immotile sperm", "Immune dysregulation", "Immunodeficiency", "Immunologic hypersensitivity", "Impacted tooth", "Impaired adp induced platelet aggregation", "Impaired antigen specific response", "Impaired collagen induced platelet aggregation", "Impaired distal proprioception", "Impaired distal tactile sensation", "Impaired distal vibration sensation", "Impaired epinephrine induced platelet aggregation", "Impaired glucose tolerance", "Impaired horizontal smooth pursuit", "Impaired mastication", "Impaired neutrophil bactericidal activity", "Impaired oropharyngeal swallow response", "Impaired pain sensation", "Impaired proprioception", "Impaired smooth pursuit", "Impaired social interactions", "Impaired t cell function", "Impaired tactile sensation", "Impaired tandem gait", "Impaired temperature sensation", "Impaired use of nonverbal behaviors", "Impaired vibration sensation at ankles", "Impaired vibration sensation in the lower limbs", "Impaired vibratory sensation", "Impaired visuospatial constructive cognition", "Impairment in personality functioning", "Impairment of activities of daily living", "Impotence", "Inability to walk", "Inappropriate antidiuretic hormone secretion", "Inappropriate behavior", "Inappropriate crying", "Inappropriate laughter", "Incisor macrodontia", "Incomitant strabismus", "Incomplete partition of the cochlea type ii", "Incomplete penetrance", "Incomprehensible speech", "Incoordination", "Increased adipose tissue", "Increased arm span", "Increased aspartate family amino acid level in urine", "Increased b cell count", "Increased blood pressure", "Increased blood urea nitrogen", "Increased body mass index", "Increased body weight", "Increased bone mineral density", "Increased c peptide level", "Increased cerebral lipofuscin", "Increased circulating acth level", "Increased circulating androgen concentration", "Increased circulating antibody level", "Increased circulating cortisol level", "Increased circulating gonadotropin level", "Increased circulating iga level", "Increased circulating igg level", "Increased circulating igm level", "Increased circulating lactate dehydrogenase concentration", "Increased circulating prolactin concentration", "Increased circulating renin level", "Increased connective tissue", "Increased csf lactate", "Increased density of long bones", "Increased endomysial connective tissue", "Increased fecal porphyrin", "Increased female libido", "Increased head circumference", "Increased hepatic glycogen content", "Increased hepatocellular lipid droplets", "Increased intracranial pressure", "Increased intramyocellular lipid droplets", "Increased laxity of ankles", "Increased ldl cholesterol concentration", "Increased level of hippuric acid in urine", "Increased level of l fucose in urine", "Increased mean corpuscular hemoglobin concentration", "Increased mean corpuscular volume", "Increased megakaryocyte count", "Increased muscle fatiguability", "Increased muscle glycogen content", "Increased muscle lipid content", "Increased nuchal translucency", "Increased overbite", "Increased proteinogenic amino acid level in urine", "Increased sensitivity to ionizing radiation", "Increased serine family amino acid in urine", "Increased serum iron", "Increased serum lactate", "Increased serum pyruvate", "Increased serum serotonin", "Increased serum testosterone level", "Increased skull ossification", "Increased sulfur amino acid level in urine", "Increased susceptibility to fractures", "Increased theta frequency activity in eeg", "Increased total bilirubin", "Increased urinary cortisol level", "Increased urinary non proteinogenic amino acid level", "Increased urine alpha ketoglutarate concentration", "Increased urine proteinogenic amino acid derivative level", "Increased vertebral height", "Increased vldl cholesterol concentration", "Ineffective esophageal peristalsis", "Infantile axial hypotonia", "Infantile encephalopathy", "Infantile muscular hypotonia", "Infantile onset", "Infantile spasms", "Infection related seizure", "Infectious encephalitis", "Inferior lens subluxation", "Inferior vermis hypoplasia", "Infertility", "Inflammation of the large intestine", "Inflammatory abnormality of the eye", "Inflexible adherence to routines or rituals", "Inguinal freckling", "Inguinal hernia", "Insidious onset", "Insomnia", "Inspiratory stridor", "Insulin resistance", "Insulin resistant diabetes mellitus", "Intellectual disability borderline", "Intellectual disability mild", "Intellectual disability moderate", "Intellectual disability profound", "Intellectual disability progressive", "Intellectual disability severe", "Intercostal muscle weakness", "Interictal eeg abnormality", "Intermittent diarrhea", "Intermittent episodes of respiratory insufficiency due to muscle weakness", "Internally nucleated skeletal muscle fibers", "Interrupted aortic arch", "Interstitial cardiac fibrosis", "Interstitial pneumonitis", "Intestinal atresia", "Intestinal fistula", "Intestinal hypoplasia", "Intestinal malrotation", "Intestinal polyp", "Intestinal pseudo obstruction", "Intraalveolar phospholipid accumulation", "Intracellular accumulation of autofluorescent lipopigment storage material", "Intracranial hemorrhage", "Intracranial meningioma", "Intractable diarrhea", "Intrauterine growth retardation", "Intrinsic hand muscle atrophy", "Intussusception", "Inverted nipples", "Involuntary movements", "Iridocyclitis", "Iris atrophy", "Iris coloboma", "Iris hypopigmentation", "Iron accumulation in brain", "Iron accumulation in globus pallidus", "Iron deficiency anemia", "Irregular epiphyses", "Irregular femoral epiphysis", "Irregular hyperpigmentation", "Irregular menstruation", "Irregular vertebral endplates", "Irritability", "Ischemic stroke", "J shaped sella turcica", "Jaundice", "Jerky head movements", "Joint contracture of the 5th finger", "Joint contracture of the hand", "Joint contractures involving the joints of the feet", "Joint dislocation", "Joint hemorrhage", "Joint hyperflexibility", "Joint hypermobility", "Joint laxity", "Joint stiffness", "Joint subluxation", "Joint swelling", "Juvenile aseptic necrosis", "Juvenile cataract", "Juvenile myelomonocytic leukemia", "Juvenile onset", "Juvenile rheumatoid arthritis", "Keloids", "Keratitis", "Keratoconjunctivitis", "Keratosis pilaris", "Ketoacidosis", "Ketonuria", "Ketosis", "Ketotic hypoglycemia", "Kinetic tremor", "Knee clonus", "Knee dislocation", "Knee flexion contracture", "Kyphoscoliosis", "Kyphosis", "Labial hypertrophy", "Lack of insight", "Lack of peer relationships", "Lack of skin elasticity", "Lack of t cell function", "Lacrimal duct atresia", "Lacrimal duct stenosis", "Lacrimation abnormality", "Lactic acidosis", "Lacticaciduria", "Lactose intolerance", "Lagopthalmos", "Lambdoidal craniosynostosis", "Language impairment", "Large basal ganglia", "Large beaked nose", "Large earlobe", "Large face", "Large fleshy ears", "Large for gestational age", "Large foramen magnum", "Large forehead", "Large hands", "Large iliac wing", "Large intestinal polyposis", "Large placenta", "Large sella turcica", "Laryngeal cleft", "Laryngeal hypoplasia", "Laryngeal stenosis", "Laryngeal stridor", "Laryngomalacia", "Laryngotracheomalacia", "Late onset", "Lateral clavicle hook", "Leber optic atrophy", "Left atrial enlargement", "Left bundle branch block", "Left to right shunt", "Left ventricular hypertrophy", "Left ventricular noncompaction cardiomyopathy", "Left ventricular outflow tract obstruction", "Left ventricular systolic dysfunction", "Leg muscle stiffness", "Leiomyosarcoma", "Lens subluxation", "Lethal skeletal dysplasia", "Lethargy", "Leukemia", "Leukocytosis", "Leukodystrophy", "Leukoencephalopathy", "Leukonychia", "Leukopenia", "Lewy bodies", "Leydig cell neoplasia", "Lichenification", "Limb ataxia", "Limb dysmetria", "Limb dystonia", "Limb fasciculations", "Limb girdle muscle atrophy", "Limb girdle muscle weakness", "Limb girdle muscular dystrophy", "Limb hypertonia", "Limb joint contracture", "Limb muscle weakness", "Limb myoclonus", "Limb pain", "Limb tremor", "Limb undergrowth", "Limitation of joint mobility", "Limitation of knee mobility", "Limitation of movement at ankles", "Limitation of neck motion", "Limited elbow extension", "Limited elbow movement", "Limited extraocular movements", "Limited hip movement", "Limited wrist movement", "Lipid accumulation in hepatocytes", "Lipoatrophy", "Lipodystrophy", "Lipoma", "Lissencephaly", "Liver abscess", "Lobulated tongue", "Localized hirsutism", "Localized osteoporosis", "Localized skin lesion", "Long clavicles", "Long ear", "Long eyelashes", "Long fingers", "Long foot", "Long hallux", "Long neck", "Long nose", "Long palm", "Long palpebral fissure", "Long penis", "Long philtrum", "Long thorax", "Long toe", "Long upper lip", "Lop ear", "Loss of ability to walk", "Loss of consciousness", "Loss of eyelashes", "Loss of purkinje cells in the cerebellar vermis", "Loss of speech", "Loss of subcutaneous adipose tissue in limbs", "Loss of voice", "Low alkaline phosphatase", "Low anterior hairline", "Low apgar score", "Low back pain", "Low frustration tolerance", "Low grade fever", "Low hanging columella", "Low levels of vitamin d", "Low molecular weight proteinuria", "Low plasma citrulline", "Low posterior hairline", "Low self esteem", "Low set nipples", "Low set posteriorly rotated ears", "Lower extremity joint dislocation", "Lower eyelid coloboma", "Lower limb amyotrophy", "Lower limb asymmetry", "Lower limb hyperreflexia", "Lower limb hypertonia", "Lower limb metaphyseal irregularity", "Lower limb muscle weakness", "Lower limb pain", "Lower limb spasticity", "Lower limb undergrowth", "Lumbar hyperlordosis", "Lumbar kyphosis", "Lumbar scoliosis", "Lung adenocarcinoma", "Lymphangiectasis", "Lymphangioma", "Lymphedema", "Lymphocytosis", "Lymphoma", "Lymphopenia", "Lymphoproliferative disorder", "Macrocephaly at birth", "Macrocytic anemia", "Macrodactyly", "Macrodontia", "Macrodontia of permanent maxillary central incisor", "Macroglossia", "Macrogyria", "Macroorchidism", "Macroscopic hematuria", "Macrotia", "Macrovesicular hepatic steatosis", "Macular atrophy", "Macular coloboma", "Macular degeneration", "Macular dystrophy", "Macular hyperpigmentation", "Macular purpura", "Macular thickening", "Macule", "Malabsorption", "Malar prominence", "Male hypogonadism", "Male infertility", "Male pseudohermaphroditism", "Male reproductive system neoplasm", "Male sexual dysfunction", "Malignant genitourinary tract tumor", "Malignant hyperthermia", "Malignant neoplasm of the central nervous system", "Malnutrition", "Malrotation of small bowel", "Mandibular aplasia", "Mandibular prognathia", "Mania", "Mask like facies", "Mastoiditis", "Maternal hypertension", "Maturity onset diabetes of the young", "Meconium stained amniotic fluid", "Medial flaring of the eyebrow", "Median cleft lip", "Median cleft palate", "Mediastinal lymphadenopathy", "Medullary nephrocalcinosis", "Medulloblastoma", "Megalencephaly", "Megaloblastic anemia", "Megalocornea", "Melanocytic nevus", "Melanoma", "Melena", "Membranoproliferative glomerulonephritis", "Memory impairment", "Meningioma", "Meningitis", "Meningocele", "Menorrhagia", "Mental deterioration", "Mesoaxial hand polydactyly", "Mesoaxial polydactyly", "Mesomelia", "Metabolic acidosis", "Metabolic alkalosis", "Metacarpophalangeal joint contracture", "Metamorphopsia", "Metaphyseal chondrodysplasia", "Metaphyseal cupping", "Metaphyseal dysplasia", "Metaphyseal irregularity", "Metaphyseal sclerosis", "Metaphyseal striations", "Metaphyseal widening", "Metatarsal synostosis", "Metatarsus adductus", "Metatarsus valgus", "Methemoglobinemia", "Methylmalonic acidemia", "Methylmalonic aciduria", "Metopic synostosis", "Metrorrhagia", "Microcornea", "Microcytic anemia", "Microdontia", "Microglossia", "Micrographia", "Micromelia", "Micronodular cirrhosis", "Micropenis", "Microphallus", "Microretrognathia", "Microscopic hematuria", "Microtia third degree", "Microvesicular hepatic steatosis", "Middle age onset", "Midface retrusion", "Midline defect of the nose", "Migraine", "Mild global developmental delay", "Mild hearing impairment", "Mild microcephaly", "Mild postnatal growth retardation", "Mild short stature", "Mildly elevated creatine kinase", "Milia", "Minicore myopathy", "Minimal change glomerulonephritis", "Miosis", "Misalignment of incisors", "Missing ribs", "Mitochondrial inheritance", "Mitochondrial myopathy", "Mitochondrial respiratory chain defects", "Mitral stenosis", "Mitral valve calcification", "Mitral valve prolapse", "Mitten deformity", "Mixed demyelinating and axonal polyneuropathy", "Mixed hearing impairment", "Mixed hypo and hyperpigmentation of the skin", "Moderate albuminuria", "Moderate global developmental delay", "Moderate sensorineural hearing impairment", "Moderately reduced visual acuity", "Molar tooth sign on mri", "Molluscoid pseudotumors", "Molluscum contagiosum", "Monochromacy", "Monocytosis", "Monotonic speech", "Mood swings", "Morning glory anomaly", "Morning myoclonic jerks", "Morphological abnormality of the corticospinal tract", "Morphological abnormality of the middle ear", "Morphological abnormality of the pyramidal tract", "Morphological abnormality of the vestibule of the inner ear", "Mortality aging", "Motor axonal neuropathy", "Motor delay", "Motor deterioration", "Motor neuron atrophy", "Motor polyneuropathy", "Motor regression", "Motor seizure", "Mottled pigmentation", "Movement abnormality of the tongue", "Moyamoya phenomenon", "Mucosal telangiectasiae", "Multicystic kidney dysplasia", "Multifactorial inheritance", "Multifocal cerebral white matter abnormalities", "Multifocal epileptiform discharges", "Multifocal seizures", "Multiple cafe au lait spots", "Multiple enchondromatosis", "Multiple exostoses", "Multiple gastric polyps", "Multiple glomerular cysts", "Multiple impacted teeth", "Multiple joint contractures", "Multiple joint dislocation", "Multiple lentigines", "Multiple lipomas", "Multiple mitochondrial dna deletions", "Multiple myeloma", "Multiple prenatal fractures", "Multiple renal cysts", "Multiple rib fractures", "Multiple rows of eyelashes", "Multiple suture craniosynostosis", "Muscle abnormality related to mitochondrial dysfunction", "Muscle fiber atrophy", "Muscle fiber inclusion bodies", "Muscle fiber necrosis", "Muscle fiber splitting", "Muscle fiber tubular inclusions", "Muscle fibrillation", "Muscle flaccidity", "Muscle hypertrophy of the lower extremities", "Muscle spasm", "Muscle stiffness", "Muscle weakness", "Muscular dystrophy", "Muscular hypotonia of the trunk", "Muscular ventricular septal defect", "Mutism", "Myalgia", "Mydriasis", "Myelodysplasia", "Myelofibrosis", "Myeloid leukemia", "Myelomeningocele", "Myelopathy", "Myeloproliferative disorder", "Myocardial fibrosis", "Myoclonic absence seizure", "Myoclonic seizure", "Myoclonic spasms", "Myoclonus", "Myofibrillar myopathy", "Myoglobinuria", "Myokymia", "Myopathic facies", "Myopathy", "Myopia", "Myositis", "Myotonia", "Naevus flammeus of the eyelid", "Nail dysplasia", "Nail dystrophy", "Nail pits", "Narrow face", "Narrow foot", "Narrow foramen obturatorium", "Narrow forehead", "Narrow iliac wing", "Narrow internal auditory canal", "Narrow jaw", "Narrow mouth", "Narrow nasal bridge", "Narrow nasal ridge", "Narrow nose", "Narrow palate", "Narrow palpebral fissure", "Narrow pelvis bone", "Narrow vertebral interpedicular distance", "Nasal congestion", "Nasal regurgitation", "Nasal speech", "Nasogastric tube feeding", "Nasogastric tube feeding in infancy", "Nasolacrimal duct obstruction", "Natal tooth", "Nausea", "Nausea and vomiting", "Neck flexor weakness", "Neck muscle weakness", "Negativism", "Nemaline bodies", "Neonatal alloimmune thrombocytopenia", "Neonatal asphyxia", "Neonatal breathing dysregulation", "Neonatal death", "Neonatal hyperbilirubinemia", "Neonatal hypoglycemia", "Neonatal hypotonia", "Neonatal insulin dependent diabetes mellitus", "Neonatal onset", "Neonatal respiratory distress", "Neoplasm", "Neoplasm by histology", "Neoplasm of fatty tissue", "Neoplasm of head and neck", "Neoplasm of striated muscle", "Neoplasm of the adrenal cortex", "Neoplasm of the adrenal gland", "Neoplasm of the breast", "Neoplasm of the colon", "Neoplasm of the ear", "Neoplasm of the endocrine system", "Neoplasm of the eye", "Neoplasm of the gallbladder", "Neoplasm of the gastrointestinal tract", "Neoplasm of the genitourinary tract", "Neoplasm of the heart", "Neoplasm of the inner ear", "Neoplasm of the large intestine", "Neoplasm of the larynx", "Neoplasm of the liver", "Neoplasm of the male external genitalia", "Neoplasm of the middle ear", "Neoplasm of the nervous system", "Neoplasm of the oral cavity", "Neoplasm of the pancreas", "Neoplasm of the parathyroid gland", "Neoplasm of the peripheral nervous system", "Neoplasm of the pituitary gland", "Neoplasm of the rectum", "Neoplasm of the respiratory system", "Neoplasm of the skeletal system", "Neoplasm of the skin", "Neoplasm of the small intestine", "Neoplasm of the stomach", "Neoplasm of the thyroid gland", "Neoplasm of the tongue", "Neoplasm of the tracheobronchial system", "Nephritis", "Nephrocalcinosis", "Nephrogenic diabetes insipidus", "Nephrolithiasis", "Nephronophthisis", "Nephropathy", "Nephrotic syndrome", "Neuralgia", "Neurodegeneration", "Neuroendocrine neoplasm", "Neurofibrillary tangles", "Neurofibromas", "Neurogenic bladder", "Neuroinflammation", "Neuroma", "Neuromuscular dysphagia", "Neuronal loss in basal ganglia", "Neuronal loss in central nervous system", "Neuronal loss in the cerebral cortex", "Neuropathic arthropathy", "Neutropenia in presence of anti neutropil antibodies", "Neutrophilia", "Nevus", "Night sweats", "No social interaction", "Nocturia", "Nocturnal hypoventilation", "Nocturnal seizures", "Non hodgkin lymphoma", "Non midline cleft lip", "Non midline cleft palate", "Non motor seizure", "Non obstructive azoospermia", "Noncompaction cardiomyopathy", "Nonimmune hydrops fetalis", "Nonketotic hypoglycemia", "Nonprogressive", "Nonprogressive cerebellar ataxia", "Nonprogressive encephalopathy", "Nonspherocytic hemolytic anemia", "Normochromic anemia", "Normocytic anemia", "Nuchal rigidity", "Nuclear cataract", "Numerous nevi", "Numerous pigmented freckles", "Nyctalopia", "Nystagmus induced head nodding", "Obsessive compulsive behavior", "Obsessive compulsive trait", "Obstructive sleep apnea", "Occipital cortical atrophy", "Occipital encephalocele", "Occipital meningocele", "Ocular albinism", "Ocular anterior segment dysgenesis", "Ocular pain", "Oculogyric crisis", "Oculomotor apraxia", "Oculomotor nerve palsy", "Odontogenic neoplasm", "Oligoarthritis", "Oligodactyly", "Oligodontia", "Oligohydramnios", "Oligomenorrhea", "Oligosacchariduria", "Oligospermia", "Oliguria", "Olivopontocerebellar atrophy", "Olivopontocerebellar hypoplasia", "Omphalocele", "Onion bulb formation", "Onset", "Onychogryposis", "Onychogryposis of toenails", "Onycholysis", "Onychomycosis", "Open angle glaucoma", "Open bite", "Open mouth", "Open operculum", "Ophthalmoparesis", "Opisthotonus", "Opportunistic infection", "Opsoclonus", "Optic atrophy", "Optic disc coloboma", "Optic disc hypoplasia", "Optic disc pallor", "Optic nerve dysplasia", "Optic nerve hypoplasia", "Optic neuropathy", "Oral aversion", "Oral cavity bleeding", "Oral cleft", "Oral leukoplakia", "Oral mucosal blisters", "Oral pharyngeal dysphagia", "Oral ulcer", "Orchitis", "Organic aciduria", "Orofacial dyskinesia", "Oromandibular dystonia", "Oromotor apraxia", "Oroticaciduria", "Orthopnea", "Orthostatic hypotension", "Orthostatic hypotension due to autonomic dysfunction", "Osteoarthritis", "Osteochondroma", "Osteochondrosis", "Osteolysis", "Osteolysis involving bones of the feet", "Osteolysis involving bones of the upper limbs", "Osteolytic defects of the distal phalanges of the hand", "Osteomalacia", "Osteomyelitis", "Osteopenia", "Osteopetrosis", "Osteoporosis", "Osteosarcoma", "Otitis media", "Otosclerosis", "Oval face", "Ovarian carcinoma", "Ovarian cyst", "Ovarian gonadoblastoma", "Ovarian neoplasm", "Ovarian papillary adenocarcinoma", "Overfolding of the superior helices", "Overfriendliness", "Overgrowth", "Overhanging nasal tip", "Overlapping fingers", "Overlapping toe", "Overriding aorta", "Overtubulated long bones", "Overweight", "Ovoid vertebral bodies", "Oxycephaly", "Pace of progression", "Pain", "Pain in head and neck region", "Pain insensitivity", "Painless fractures due to injury", "Pallor", "Palmar hyperhidrosis", "Palmar pits", "Palmar telangiectasia", "Palmoplantar blistering", "Palmoplantar cutis laxa", "Palmoplantar hyperhidrosis", "Palpebral edema", "Palpitations", "Pancreatic adenocarcinoma", "Pancreatic cysts", "Pancreatic fibrosis", "Pancreatic hypoplasia", "Pancreatic islet cell hyperplasia", "Pancreatitis", "Pancytopenia", "Panhypogammaglobulinemia", "Panhypopituitarism", "Panniculitis", "Papillary renal cell carcinoma", "Papillary thyroid carcinoma", "Papilledema", "Papilloma", "Papule", "Paracentral scotoma", "Paraganglioma", "Parakeratosis", "Paralysis", "Paranoia", "Paraparesis", "Paraplegia", "Paraplegia paraparesis", "Parasomnia", "Parathyroid adenoma", "Parathyroid carcinoma", "Parathyroid dysgenesis", "Paresthesia", "Parietal bossing", "Parietal cortical atrophy", "Parietal foramina", "Parkinsonism", "Parkinsonism with favorable response to dopaminergic medication", "Paronychia", "Paroxysmal bursts of laughter", "Paroxysmal dyskinesia", "Paroxysmal dystonia", "Paroxysmal involuntary eye movements", "Paroxysmal ventricular tachycardia", "Partial absence of thumb", "Partial agenesis of the corpus callosum", "Partial anomalous pulmonary venous return", "Partial duplication of the phalanx of hand", "Patchy alopecia", "Patchy changes of bone mineral density", "Patchy hypopigmentation of hair", "Patchy palmoplantar hyperkeratosis", "Patellar aplasia", "Patellar dislocation", "Patellar hypoplasia", "Patellar subluxation", "Patent ductus arteriosus", "Patent foramen ovale", "Pathologic fracture", "Pectus carinatum", "Pectus excavatum", "Pectus excavatum of inferior sternum", "Pedal edema", "Pediatric onset", "Pelvic girdle muscle weakness", "Pelvic kidney", "Pendular nystagmus", "Penetrating foot ulcers", "Peptic ulcer", "Perianal abscess", "Periauricular skin pits", "Pericardial effusion", "Pericarditis", "Perifoveal ring of hyperautofluorescence", "Perimembranous ventricular septal defect", "Periodic paralysis", "Periodontitis", "Periorbital edema", "Periorbital fullness", "Peripheral arterial stenosis", "Peripheral axonal degeneration", "Peripheral axonal neuropathy", "Peripheral cyanosis", "Peripheral demyelination", "Peripheral edema", "Peripheral hypermyelination", "Peripheral hypomyelination", "Peripheral neuropathy", "Peripheral opacification of the cornea", "Peripheral pulmonary artery stenosis", "Peripheral retinal avascularization", "Peripheral visual field loss", "Periportal fibrosis", "Perisylvian polymicrogyria", "Peritoneal abscess", "Peritonitis", "Periventricular cysts", "Periventricular heterotopia", "Periventricular leukomalacia", "Periventricular nodular heterotopia", "Periventricular white matter hyperintensities", "Peroneal muscle atrophy", "Perseveration", "Persistence of hemoglobin f", "Persistence of primary teeth", "Persistent ebv viremia", "Persistent head lag", "Personality changes", "Pes cavus", "Pes planus", "Pes valgus", "Petechiae", "Peters anomaly", "Phalangeal dislocation", "Pharyngitis", "Phenotypic variability", "Pheochromocytoma", "Phimosis", "Phocomelia", "Phonophobia", "Photophobia", "Photopsia", "Photoreceptor layer loss on macular oct", "Photosensitive tonic clonic seizure", "Phthisis bulbi", "Physical urticaria", "Pierre robin sequence", "Pigmentary retinopathy", "Pili canaliculi", "Pili torti", "Pilomatrixoma", "Pineal cyst", "Pituitary adenoma", "Pituitary growth hormone cell adenoma", "Pituitary hypothyroidism", "Pituitary prolactin cell adenoma", "Plagiocephaly", "Plantar hyperkeratosis", "Platybasia", "Platyspondyly", "Pleural effusion", "Pleuritis", "Pneumonia", "Pneumothorax", "Poikilocytosis", "Poikiloderma", "Pointed chin", "Polar cataract", "Pollakisuria", "Polyarticular arthropathy", "Polycystic kidney dysplasia", "Polycystic liver disease", "Polycythemia", "Polydactyly", "Polygenic inheritance", "Polyhydramnios", "Polymicrogyria", "Polyneuropathy", "Polyphagia", "Polysplenia", "Polyuria", "Pontocerebellar atrophy", "Poor appetite", "Poor coordination", "Poor eye contact", "Poor fine motor coordination", "Poor gross motor coordination", "Poor head control", "Poor motor coordination", "Poor speech", "Poor suck", "Poor wound healing", "Porencephalic cyst", "Porokeratosis", "Porphyrinuria", "Portal fibrosis", "Portal vein thrombosis", "Positional foot deformity", "Positive romberg sign", "Post partum hemorrhage", "Postaxial foot polydactyly", "Postaxial hand polydactyly", "Postaxial polydactyly", "Posterior embryotoxon", "Posterior fossa cyst", "Posterior pharyngeal cleft", "Posterior pituitary dysgenesis", "Posterior polar cataract", "Posterior subcapsular cataract", "Posteriorly rotated ears", "Postexertional malaise", "Postnatal growth retardation", "Postural instability", "Postural tremor", "Potter facies", "Preauricular skin tag", "Preaxial foot polydactyly", "Preaxial hand polydactyly", "Preaxial polydactyly", "Precocious atherosclerosis", "Predominantly lower limb lymphedema", "Prelingual sensorineural hearing impairment", "Premature adrenarche", "Premature arteriosclerosis", "Premature birth", "Premature coronary artery atherosclerosis", "Premature graying of hair", "Premature loss of primary teeth", "Premature loss of teeth", "Premature osteoarthritis", "Premature ovarian insufficiency", "Premature pubarche", "Premature rupture of membranes", "Premature skin wrinkling", "Premature thelarche", "Premature ventricular contraction", "Prematurely aged appearance", "Prenatal maternal abnormality", "Prenatal movement abnormality", "Primary adrenal insufficiency", "Primary amenorrhea", "Primary congenital glaucoma", "Primary gonadal insufficiency", "Primary hypercortisolism", "Primary hyperparathyroidism", "Primary microcephaly", "Primary peritoneal carcinoma", "Primitive neuroectodermal tumor", "Primitive reflex", "Productive cough", "Profound global developmental delay", "Profound hearing impairment", "Profound sensorineural hearing impairment", "Progeroid facial appearance", "Progressive", "Progressive cerebellar ataxia", "Progressive distal muscle weakness", "Progressive encephalopathy", "Progressive external ophthalmoplegia", "Progressive extrapyramidal movement disorder", "Progressive flexion contractures", "Progressive gait ataxia", "Progressive hearing impairment", "Progressive inability to walk", "Progressive leukoencephalopathy", "Progressive macrocephaly", "Progressive microcephaly", "Progressive muscle weakness", "Progressive neurologic deterioration", "Progressive night blindness", "Progressive peripheral neuropathy", "Progressive pes cavus", "Progressive proximal muscle weakness", "Progressive psychomotor deterioration", "Progressive pulmonary function impairment", "Progressive sensorineural hearing impairment", "Progressive spastic paraparesis", "Progressive spastic paraplegia", "Progressive spastic quadriplegia", "Progressive spasticity", "Progressive visual field defects", "Progressive visual loss", "Prolinuria", "Prolonged bleeding after dental extraction", "Prolonged bleeding after surgery", "Prolonged bleeding following circumcision", "Prolonged bleeding following procedure", "Prolonged bleeding time", "Prolonged neonatal jaundice", "Prolonged partial thromboplastin time", "Prolonged pr interval", "Prolonged qtc interval", "Prominent antihelix", "Prominent antitragus", "Prominent calcaneus", "Prominent crus of helix", "Prominent digit pad", "Prominent ear helix", "Prominent eyelashes", "Prominent forehead", "Prominent metopic ridge", "Prominent nasal bridge", "Prominent nasal tip", "Prominent nasolabial fold", "Prominent nose", "Prominent occiput", "Prominent sternum", "Prominent superficial blood vessels", "Prominent supraorbital ridges", "Prominent umbilicus", "Prominent veins on trunk", "Proportionate short stature", "Proportionate tall stature", "Proptosis", "Prostate neoplasm", "Protein avoidance", "Protein losing enteropathy", "Protruding ear", "Protruding tongue", "Protrusio acetabuli", "Protuberant abdomen", "Proximal amyotrophy", "Proximal femoral epiphysiolysis", "Proximal femoral metaphyseal abnormality", "Proximal femoral metaphyseal irregularity", "Proximal muscle weakness", "Proximal muscle weakness in lower limbs", "Proximal muscle weakness in upper limbs", "Proximal renal tubular acidosis", "Proximal symphalangism", "Proximal tubulopathy", "Proximal upper limb amyotrophy", "Pruritus", "Pseudoarthrosis", "Pseudobulbar paralysis", "Pseudobulbar signs", "Pseudoepiphyses", "Pseudoepiphyses of hand bones", "Pseudoepiphyses of the metacarpals", "Pseudohypoaldosteronism", "Pseudohypoparathyroidism", "Psoriasiform dermatitis", "Psychogenic non epileptic seizure", "Psychomotor deterioration", "Psychomotor retardation", "Psychosis", "Psychotic episodes", "Psychotic mentation", "Pterygium", "Ptosis", "Puberty and gonadal disorders", "Pulmonary artery atresia", "Pulmonary artery dilatation", "Pulmonary artery hypoplasia", "Pulmonary artery stenosis", "Pulmonary carcinoid tumor", "Pulmonary cyst", "Pulmonary edema", "Pulmonary embolism", "Pulmonary fibrosis", "Pulmonary hemorrhage", "Pulmonary hypoplasia", "Pulmonary infiltrates", "Pulmonary insufficiency", "Pulmonary interstitial high resolution computed tomography abnormality", "Pulmonary venous hypertension", "Pulmonic stenosis", "Pulverulent cataract", "Punctate cataract", "Pure red cell aplasia", "Purpura", "Pustule", "Pyelonephritis", "Pyoderma gangrenosum", "Pyridoxine responsive sideroblastic anemia", "Quadriceps muscle weakness", "Radial bowing", "Radial deviation of the 2nd finger", "Radial deviation of the hand", "Radial deviation of the hand or of fingers of the hand", "Radioulnar dislocation", "Radioulnar synostosis", "Ragged red muscle fibers", "Rapidly progressive", "Raynaud phenomenon", "Reactive hypoglycemia", "Receptive language delay", "Rectal fistula", "Rectal prolapse", "Recurrent", "Recurrent abscess formation", "Recurrent acute respiratory tract infection", "Recurrent aspergillus infections", "Recurrent aspiration pneumonia", "Recurrent bacterial infections", "Recurrent bacterial skin infections", "Recurrent bronchitis", "Recurrent bronchopulmonary infections", "Recurrent corneal erosions", "Recurrent cutaneous abscess formation", "Recurrent ear infections", "Recurrent fever", "Recurrent fractures", "Recurrent gastroenteritis", "Recurrent hand flapping", "Recurrent herpes", "Recurrent infection of the gastrointestinal tract", "Recurrent lower respiratory tract infections", "Recurrent mycobacterial infections", "Recurrent opportunistic infections", "Recurrent otitis media", "Recurrent pancreatitis", "Recurrent paroxysmal headache", "Recurrent pharyngitis", "Recurrent pneumonia", "Recurrent respiratory infections", "Recurrent sinopulmonary infections", "Recurrent sinusitis", "Recurrent skin infections", "Recurrent staphylococcal infections", "Recurrent staphylococcus aureus infections", "Recurrent tonsillitis", "Recurrent upper and lower respiratory tract infections", "Recurrent urinary tract infections", "Recurrent viral infections", "Red eye", "Red green dyschromatopsia", "Red hair", "Reduced antigen specific t cell proliferation", "Reduced antithrombin iii activity", "Reduced brain n acetyl aspartate level by mrs", "Reduced c peptide level", "Reduced circulating prolactin concentration", "Reduced consciousness confusion", "Reduced delayed hypersensitivity", "Reduced factor viii activity", "Reduced factor xi activity", "Reduced factor xii activity", "Reduced factor xiii activity", "Reduced forced expiratory volume in one second", "Reduced forced vital capacity", "Reduced natural killer cell count", "Reduced pancreatic beta cells", "Reduced protein c activity", "Reduced protein s activity", "Reduced renal corticomedullary differentiation", "Reduced sperm motility", "Reduced subcutaneous adipose tissue", "Reduced systolic function", "Reduced tendon reflexes", "Reduced visual acuity", "Reduced vital capacity", "Reduction of neutrophil motility", "Redundant neck skin", "Redundant skin", "Reflex seizure", "Refractory anemia", "Regional abnormality of skin", "Relative macrocephaly", "Remnants of the hyaloid vascular system", "Renal agenesis", "Renal cell carcinoma", "Renal cortical cysts", "Renal cortical microcysts", "Renal corticomedullary cysts", "Renal cyst", "Renal duplication", "Renal dysplasia", "Renal fanconi syndrome", "Renal fibrosis", "Renal hamartoma", "Renal hypoplasia", "Renal hypoplasia aplasia", "Renal insufficiency", "Renal magnesium wasting", "Renal malrotation", "Renal phosphate wasting", "Renal potassium wasting", "Renal salt wasting", "Renal steatosis", "Renal tubular acidosis", "Renal tubular atrophy", "Renal tubular dysfunction", "Renal tubular epithelial necrosis", "Renovascular hypertension", "Repetitive compulsive behavior", "Respiratory alkalosis", "Respiratory arrest", "Respiratory distress", "Respiratory failure", "Respiratory failure requiring assisted ventilation", "Respiratory insufficiency", "Respiratory insufficiency due to defective ciliary clearance", "Respiratory paralysis", "Respiratory tract infection", "Response to drugs acting on neuromuscular transmission", "Resting tremor", "Restless legs", "Restlessness", "Restrictive behavior", "Restrictive cardiomyopathy", "Restrictive ventilatory defect", "Reticular hyperpigmentation", "Reticulated skin pigmentation", "Reticulocytopenia", "Reticulocytosis", "Retinal arterial tortuosity", "Retinal arteriolar tortuosity", "Retinal atrophy", "Retinal coloboma", "Retinal degeneration", "Retinal detachment", "Retinal dysplasia", "Retinal dystrophy", "Retinal fold", "Retinal hamartoma", "Retinal hemorrhage", "Retinal neovascularization", "Retinal perforation", "Retinal pigment epithelial atrophy", "Retinal pigment epithelial mottling", "Retinal telangiectasia", "Retinal thinning", "Retinal vascular tortuosity", "Retinopathy", "Retrocollis", "Retrognathia", "Rhabdomyolysis", "Rhabdomyosarcoma", "Rhegmatogenous retinal detachment", "Rheumatoid arthritis", "Rheumatoid factor positive", "Rhinitis", "Rhizomelia", "Rib fusion", "Rib segmentation abnormalities", "Rickets", "Ridged nail", "Rieger anomaly", "Right aortic arch with mirror image branching", "Right bundle branch block", "Right ventricular cardiomyopathy", "Right ventricular dilatation", "Right ventricular hypertrophy", "Rigidity", "Rimmed vacuoles", "Rod cone dystrophy", "Rotary nystagmus", "Round ear", "Round face", "Saccadic oscillation", "Saccadic smooth pursuit", "Sacrococcygeal teratoma", "Sagittal craniosynostosis", "Sandal gap", "Sarcoma", "Scaling skin", "Scanning speech", "Scaphocephaly", "Scapular winging", "Scarring", "Scarring alopecia of scalp", "Schistocytosis", "Schizencephaly", "Schizophrenia", "Schwannoma", "Scleral staphyloma", "Sclerocornea", "Scleroderma", "Sclerosis of hand bone", "Sclerosis of skull base", "Scotoma", "Scrotal hypoplasia", "Sea blue histiocytosis", "Seborrheic dermatitis", "Second degree atrioventricular block", "Secondary amenorrhea", "Secondary growth hormone deficiency", "Secondary microcephaly", "Secretory diarrhea", "Secundum atrial septal defect", "Segmental peripheral demyelination remyelination", "Selective tooth agenesis", "Self injurious behavior", "Self mutilation", "Semilobar holoprosencephaly", "Senile plaques", "Sensorimotor neuropathy", "Sensory ataxia", "Sensory axonal neuropathy", "Sensory neuropathy", "Sepsis", "Septate vagina", "Septic arthritis", "Septo optic dysplasia", "Serositis", "Severe combined immunodeficiency", "Severe cytomegalovirus infection", "Severe demyelination of the white matter", "Severe expressive language delay", "Severe failure to thrive", "Severe global developmental delay", "Severe hearing impairment", "Severe infection", "Severe intrauterine growth retardation", "Severe lactic acidosis", "Severe muscular hypotonia", "Severe photosensitivity", "Severe postnatal growth retardation", "Severe short limb dwarfism", "Severe short stature", "Severe varicella zoster infection", "Severe viral infection", "Severely reduced visual acuity", "Shagreen patch", "Shallow acetabular fossae", "Shallow anterior chamber", "Shallow orbits", "Shawl scrotum", "Shield chest", "Shock", "Short 1st metacarpal", "Short attention span", "Short chin", "Short clavicles", "Short columella", "Short digit", "Short face", "Short femur", "Short foot", "Short fourth metatarsal", "Short lingual frenulum", "Short long bone", "Short lower limbs", "Short middle phalanx of finger", "Short nail", "Short nose", "Short palm", "Short palpebral fissure", "Short phalanx of the thumb", "Short philtrum", "Short proximal phalanx of finger", "Short ribs", "Short stepped shuffling gait", "Short sternum", "Short thorax", "Short thumb", "Short tibia", "Short umbilical cord", "Short upper lip", "Shortened pr interval", "Shortened qt interval", "Shortening of all distal phalanges of the fingers", "Shortening of all middle phalanges of the fingers", "Shoulder dislocation", "Shoulder girdle muscle atrophy", "Shoulder girdle muscle weakness", "Shoulder pain", "Shuffling gait", "Shyness", "Sick sinus syndrome", "Sideroblastic anemia", "Simple ear", "Simple febrile seizure", "Simplified gyral pattern", "Single fiber emg abnormality", "Single naris", "Single transverse palmar crease", "Single ventricle", "Sinus bradycardia", "Sinus tachycardia", "Sirenomelia", "Skeletal dysplasia", "Skeletal muscle atrophy", "Skeletal muscle hypertrophy", "Skeletal myopathy", "Skin appendage neoplasm", "Skin dimple", "Skin erosion", "Skin nodule", "Skin picking", "Skin pit", "Skin plaque", "Skin rash", "Skin tags", "Skin ulcer", "Skin vesicle", "Skull asymmetry", "Slanting of the palpebral fissure", "Sleep apnea", "Sleep disturbance", "Sleep wake cycle disturbance", "Slender build", "Slender finger", "Slender long bone", "Sloping forehead", "Slow decrease in visual acuity", "Slow pupillary light response", "Slow saccadic eye movements", "Slowed slurred speech", "Slowly progressive", "Slurred speech", "Small anterior fontanelle", "Small basal ganglia", "Small cerebral cortex", "Small earlobe", "Small epiphyses", "Small face", "Small for gestational age", "Small hand", "Small intestinal dysmotility", "Small nail", "Small pituitary gland", "Small placenta", "Smooth muscle antibody positivity", "Smooth philtrum", "Snoring", "Social and occupational deterioration", "Soft doughy skin", "Soft skin", "Soft tissue sarcoma", "Solitary median maxillary central incisor", "Somatic mutation", "Somatic sensory dysfunction", "Sound sensitivity", "Sparse and thin eyebrow", "Sparse body hair", "Sparse eyebrow", "Sparse eyelashes", "Sparse hair", "Sparse lateral eyebrow", "Sparse or absent eyelashes", "Sparse scalp hair", "Spastic ataxia", "Spastic diplegia", "Spastic dysarthria", "Spastic gait", "Spastic hyperactive bladder", "Spastic paraparesis", "Spastic paraparetic gait", "Spastic paraplegia", "Spastic tetraparesis", "Spastic tetraplegia", "Spasticity", "Specific learning disability", "Speech apraxia", "Speech articulation difficulties", "Spina bifida", "Spina bifida occulta", "Spinal canal stenosis", "Spinal cord compression", "Spinal cord lesion", "Spinal cord tumor", "Spinal deformities", "Spinal muscular atrophy", "Spinal rigidity", "Splanchnic vein thrombosis", "Splenomegaly", "Split nail", "Spoken word recognition deficit", "Spondyloepimetaphyseal dysplasia", "Spondyloepiphyseal dysplasia", "Spondylolisthesis", "Spondylolysis", "Spontaneous abortion", "Spontaneous hemolytic crises", "Spontaneous pain sensation", "Spontaneous recurrent epistaxis", "Sporadic", "Spotty hyperpigmentation", "Sprengel anomaly", "Squamous cell carcinoma", "Squamous cell carcinoma of the skin", "Square face", "Squared iliac bones", "St segment elevation", "Stage 5 chronic kidney disease", "Staring gaze", "Status epilepticus", "Status epilepticus with prominent motor symptoms", "Stenosis of the external auditory canal", "Steppage gait", "Stereotypical hand wringing", "Stereotypy", "Steroid resistant nephrotic syndrome", "Stiff skin", "Stillbirth", "Stomach cancer", "Stomatitis", "Stomatocytosis", "Stooped posture", "Streak ovary", "Striae distensae", "Stridor", "Stroke", "Stroke like episode", "Stuttering", "Subacute progressive viral hepatitis", "Subarachnoid hemorrhage", "Subcapsular cataract", "Subcortical band heterotopia", "Subcortical cerebral atrophy", "Subcortical heterotopia", "Subcutaneous hemorrhage", "Subcutaneous nodule", "Subdural hemorrhage", "Subependymal cysts", "Subglottic stenosis", "Submucous cleft of soft and hard palate", "Submucous cleft soft palate", "Subretinal fluid", "Subsarcolemmal accumulations of abnormally shaped mitochondria", "Substantia nigra gliosis", "Subvalvular aortic stenosis", "Sudden death", "Sudden episodic apnea", "Sudden loss of visual acuity", "Suicidal ideation", "Sunken cheeks", "Supernumerary bones of the axial skeleton", "Supernumerary nipple", "Supernumerary spleens", "Supernumerary tooth", "Supranuclear gaze palsy", "Supranuclear ophthalmoplegia", "Supravalvular aortic stenosis", "Supraventricular arrhythmia", "Supraventricular tachycardia", "Symphalangism affecting the phalanges of the hand", "Symphalangism of middle phalanx of finger", "Symptomatic seizures", "Syncope", "Syndactyly", "Synostosis involving bones of the hand", "Synostosis involving bones of the lower limbs", "Synostosis involving bones of the upper limbs", "Synostosis involving digits", "Synostosis of carpal bones", "Synostosis of carpals tarsals", "Synostosis of joints", "Synostosis of metacarpals metatarsals", "Synovitis", "Syringomyelia", "Systemic lupus erythematosus", "T cell lymphoma", "T lymphocytopenia", "Tachycardia", "Tachypnea", "Talipes calcaneovalgus", "Talipes equinovalgus", "Talipes equinovarus", "Talipes valgus", "Tall chin", "Tall stature", "Tapered distal phalanges of finger", "Tapered finger", "Tarsal synostosis", "Telangiectasia", "Telangiectasia of the skin", "Telecanthus", "Temperature instability", "Temporal cortical atrophy", "Temporal optic disc pallor", "Temporal pattern", "Tendon xanthomatosis", "Tented upper lip vermilion", "Teratoma", "Testicular adrenal rest tumor", "Testicular atrophy", "Testicular dysgenesis", "Tetany", "Tetralogy of fallot", "Tetraparesis", "Tetraplegia", "Tetraplegia tetraparesis", "Thenar muscle atrophy", "Thick cerebral cortex", "Thick corpus callosum", "Thick eyebrow", "Thick hair", "Thick lower lip vermilion", "Thick nasal alae", "Thick upper lip vermilion", "Thick vermilion border", "Thickened calvaria", "Thickened cortex of long bones", "Thickened ears", "Thickened helices", "Thickened nuchal skin fold", "Thickened ribs", "Thickened skin", "Thin bony cortex", "Thin clavicles", "Thin eyebrow", "Thin lower lip vermilion", "Thin nail", "Thin ribs", "Thin skin", "Thin upper lip vermilion", "Thin vermilion border", "Third degree atrioventricular block", "Thoracic aortic aneurysm", "Thoracic hypoplasia", "Thoracic kyphoscoliosis", "Thoracic kyphosis", "Thoracic scoliosis", "Thoracolumbar kyphoscoliosis", "Thoracolumbar kyphosis", "Thoracolumbar scoliosis", "Thrombocytosis", "Thromboembolism", "Thyroid adenoma", "Thyroid carcinoma", "Thyroiditis", "Tibial bowing", "Tibial torsion", "Tics", "Tiger tail banding", "Tinnitus", "Tip toe gait", "Tissue ischemia", "Titubation", "Toe clinodactyly", "Toe syndactyly", "Toe walking", "Toenail dysplasia", "Tongue atrophy", "Tongue fasciculations", "Tongue nodules", "Tongue thrusting", "Tonic seizure", "Tooth malposition", "Torsion dystonia", "Total anomalous pulmonary venous return", "Toxemia of pregnancy", "Tracheal stenosis", "Tracheobronchomalacia", "Tracheoesophageal fistula", "Tracheomalacia", "Tractional retinal detachment", "Transient global amnesia", "Transient ischemic attack", "Transient neonatal diabetes mellitus", "Transient neutropenia", "Transposition of the great arteries", "Tremor", "Tremor by anatomical site", "Triangular face", "Triangular mouth", "Triangular shaped phalanges of the hand", "Triceps weakness", "Trichorrhexis nodosa", "Tricuspid atresia", "Tricuspid stenosis", "Tricuspid valve prolapse", "Trigonocephaly", "Triphalangeal thumb", "Trismus", "Tritanomaly", "Trophic changes related to pain", "Truncal ataxia", "Truncal obesity", "Truncal titubation", "Truncus arteriosus", "Tube feeding", "Tubulointerstitial nephritis", "Turricephaly", "Type 1 fibers relatively smaller than type 2 fibers", "Type 1 muscle fiber atrophy", "Type 2 muscle fiber atrophy", "Type 2 muscle fiber predominance", "Type i diabetes mellitus", "Type i transferrin isoform profile", "Type ii diabetes mellitus", "Type ii lissencephaly", "Type ii transferrin isoform profile", "Typical absence seizure", "U shaped upper lip vermilion", "Ulnar bowing", "Ulnar claw", "Ulnar deviation of finger", "Ulnar deviation of the 2nd finger", "Ulnar deviation of the hand", "Ulnar deviation of the hand or of fingers of the hand", "Ulnar deviation of the wrist", "Uncombable hair", "Unconjugated hyperbilirubinemia", "Uncontrolled eye movements", "Underdeveloped nasal alae", "Underdeveloped supraorbital ridges", "Underdeveloped tragus", "Undetectable electroretinogram", "Undetectable light and dark adapted electroretinogram", "Undetectable visual evoked potentials", "Unexplained fevers", "Unilateral primary pulmonary dysgenesis", "Unilateral ptosis", "Unilateral renal agenesis", "Unsteady gait", "Unusual fungal infection", "Unusual infection", "Unusual infection by anatomical site", "Unusual skin infection", "Upgaze palsy", "Uplifted earlobe", "Upper airway obstruction", "Upper extremity joint dislocation", "Upper eyelid coloboma", "Upper limb amyotrophy", "Upper limb asymmetry", "Upper limb hypertonia", "Upper limb muscle weakness", "Upper limb pain", "Upper limb postural tremor", "Upper limb spasticity", "Upper limb undergrowth", "Upper motor neuron dysfunction", "Upslanted palpebral fissure", "Ureteral duplication", "Ureteral obstruction", "Ureteral stenosis", "Ureterocele", "Ureteropelvic junction obstruction", "Urethral obstruction", "Urethral stenosis", "Urethral stricture", "Urethral valve", "Urethrovaginal fistula", "Uric acid nephrolithiasis", "Urinary bladder sphincter dysfunction", "Urinary glycosaminoglycan excretion", "Urinary incontinence", "Urinary retention", "Urinary tract neoplasm", "Urinary urgency", "Urogenital fistula", "Urogenital sinus anomaly", "Urticaria", "Uterine prolapse", "Uterus didelphys", "Uveal melanoma", "Uveitis", "Vacuolated lymphocytes", "Vaginal atresia", "Vaginal fistula", "Vaginal neoplasm", "Variable expressivity", "Varicose veins", "Vascular calcification", "Vascular dilatation", "Vascular neoplasm", "Vascular skin abnormality", "Vascular tortuosity", "Vasculitis", "Vegetative state", "Vein of galen aneurysmal malformation", "Velopharyngeal insufficiency", "Venous insufficiency", "Venous malformation", "Venous thrombosis", "Ventilator dependence with inability to wean", "Ventricular arrhythmia", "Ventricular escape rhythm", "Ventricular fibrillation", "Ventricular hypertrophy", "Ventricular preexcitation", "Ventricular septal hypertrophy", "Ventricular tachycardia", "Ventriculomegaly", "Verrucae", "Vertebral arch anomaly", "Vertebral clefting", "Vertebral compression fracture", "Vertebral fusion", "Vertebral hypoplasia", "Vertebral segmentation defect", "Vertebral wedging", "Vertical nystagmus", "Vertical supranuclear gaze palsy", "Vertigo", "Very long chain fatty acid accumulation", "Vestibular dysfunction", "Viral encephalitis", "Viral hepatitis", "Viral infection induced rhabdomyolysis", "Visceral angiomatosis", "Visual acuity test abnormality", "Visual agnosia", "Visual field defect", "Visual fixation instability", "Visual hallucinations", "Visual impairment", "Visual loss", "Vitiligo", "Vitreoretinopathy", "Vitreous floaters", "Vitreous hemorrhage", "Vitritis", "Vocal cord paralysis", "Vocal cord paresis", "Volvulus", "Vomiting", "Waddling gait", "Weak cry", "Weak voice", "Weakness due to upper motor neuron dysfunction", "Weakness of facial musculature", "Weakness of long finger extensor muscles", "Weakness of muscles of respiration", "Weakness of the intrinsic hand muscles", "Webbed neck", "Weight loss", "Wheezing", "White forelock", "White hair", "Wide anterior fontanel", "Wide cranial sutures", "Wide intermamillary distance", "Wide mouth", "Wide nasal bridge", "Wide nasal ridge", "Wide nose", "Widely patent fontanelles and sutures", "Widely spaced incisors", "Widely spaced primary teeth", "Widely spaced teeth", "Widened cerebral subarachnoid space", "Widened subarachnoid space", "Widow s peak", "Woolly hair", "Wormian bones", "Wrist flexion contracture", "Writer s cramp", "X linked dominant inheritance", "X linked recessive inheritance", "Xanthelasma", "Xanthomatosis", "Xerostomia", "Y shaped metacarpals", "Yellow white lesions of the retina", "Young adult onset", "Zonular cataract"], "available_proteins": ["AAAS", "AARS", "AARS2", "AASS", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABHD12", "ACACA", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD5", "ACO2", "ACOX1", "ACP2", "ACSF3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ADAR", "ADD1", "ADD3", "ADH5", "ADK", "ADNP", "ADSL", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKT2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALG1", "AMPD2", "ANAPC1", "ANAPC2", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANO6", "ANXA11", "AP1B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "APOL2", "APPL1", "APRT", "ARCN1", "ARHGDIA", "ARHGEF2", "ARID1A", "ARL2", "ARL3", "ARL6", "ARL6IP1", "ASAH1", "ASCC1", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD3A", "ATIC", "ATP11C", "ATP1A1", "ATP2A2", "ATP5A1", "ATP6AP1", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "ATXN10", "B3GALT6", "B4GAT1", "BANF1", "BAZ1B", "BCAP31", "BCOR", "BCS1L", "BICD2", "BLVRA", "BMS1", "BPTF", "BUB1B", "BUB3", "C19orf70", "C1QBP", "CACNA2D1", "CAD", "CALD1", "CALR", "CAMK2G", "CAPN1", "CARS", "CASK", "CAST", "CBFB", "CCDC22", "CCDC47", "CCDC8", "CCT5", "CD2AP", "CDC42", "CDC73", "CDH2", "CDK13", "CDK4", "CDK5", "CENPF", "CEP55", "CFL2", "CHAMP1", "CHD1", "CHD4", "CHD7", "CHEK2", "CHMP2B", "CHMP4B", "CHORDC1", "CISD2", "CKAP2L", "CLASP1", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNNM4", "CNOT1", "CNP", "COA3", "COA7", "COG2", "COG4", "COG7", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COX15", "COX2", "COX4I1", "COX5A", "CPNE1", "CPOX", "CPSF1", "CPT2", "CRKL", "CRTAP", "CSNK2B", "CSTB", "CTBP1", "CTCF", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTSA", "CTSB", "CTSC", "CUL3", "CUL4B", "CWF19L1", "CYB5R3", "CYC1", "DARS", "DARS2", "DBR1", "DBT", "DCPS", "DCTN1", "DCTN4", "DCXR", "DDB1", "DDOST", "DDRGK1", "DDX3X", "DDX41", "DDX6", "DHCR24", "DHCR7", "DHFR", "DHX16", "DHX30", "DHX37", "DHX38", "DIABLO", "DIAPH1", "DIAPH3", "DIP2B", "DKC1", "DLAT", "DLD", "DLST", "DNAAF5", "DNAJB11", "DNAJC13", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPM1", "DSG2", "DSP", "DYNC1H1", "DYNLL1", "EARS2", "ECE1", "ECHS1", "EEF1A2", "EEF2", "EFL1", "EFTUD2", "EHMT1", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF3F", "EIF4A3", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELP1", "ELP2", "ELP4", "EMC1", "EMD", "EMG1", "EPB41", "EPHX2", "EPRS", "EPS15L1", "ERAL1", "ERAP1", "ERCC2", "ERCC3", "ERCC4", "ERGIC1", "ERLIN1", "ERLIN2", "ESS2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXOC7", "EXOSC1", "EXOSC2", "EXOSC3", "EXOSC8", "EXOSC9", "EZR", "FAH", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FBXO7", "FDFT1", "FDPS", "FDXR", "FECH", "FH", "FIP1L1", "FKBP10", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FOXRED1", "FRG1", "FSCN1", "FTO", "FUCA1", "FUS", "FXR1", "G6PD", "GAA", "GALK1", "GALM", "GALNT2", "GAMT", "GANAB", "GAPVD1", "GARS", "GATAD2B", "GATB", "GBA", "GCDH", "GDAP1", "GDAP2", "GDI1", "GEMIN4", "GEMIN5", "GFM1", "GFPT1", "GGCX", "GIGYF2", "GLA", "GLB1", "GLDC", "GLMN", "GLRX5", "GLS", "GLUD1", "GM2A", "GMPPA", "GNAI2", "GNAI3", "GNPAT", "GNS", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPHN", "GPI", "GRHPR", "GSDME", "GSR", "GSS", "GSTM3", "GTF2I", "GTPBP3", "GUSB", "GYG1", "GYS1", "H2AFY", "HADH", "HADHA", "HADHB", "HCFC1", "HELLS", "HEXA", "HEXB", "HEXIM1", "HIBCH", "HIST1H1E", "HK1", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HMBS", "HMGA1", "HMGA2", "HMGB3", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B4", "HSPA9", "HSPB1", "HSPD1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFNGR1", "IFT27", "IGBP1", "IGF1R", "IGF2BP2", "IGF2R", "IMPAD1", "INTS1", "IQSEC1", "IRF2BPL", "IRS4", "ITCH", "ITM2B", "ITPA", "IVD", "JAGN1", "JUP", "KARS", "KDM1A", "KDM3B", "KDSR", "KIAA0319L", "KIF11", "KIF14", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF4A", "KIFBP", "KMT2A", "LARP7", "LARS", "LARS2", "LAS1L", "LBR", "LDHA", "LEMD2", "LEMD3", "LETM1", "LIN28B", "LLGL1", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LONP1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRSAM1", "LSS", "LZTFL1", "MACF1", "MAGED2", "MAGT1", "MANBA", "MAP1B", "MAP2K1", "MAPK1", "MAPRE2", "MARS", "MAT2A", "MATR3", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "MECP2", "MFF", "MFN2", "MFSD8", "MGME1", "MIA3", "MICU1", "MID1", "MIF", 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setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Lysosome 26 49 4.636503123703866 3.5435284262419486e-06 21.740291262135923 48.609223300970875 0.8281821627988494 0.1302152537326229 7.142313942893836 4.247239237941681 3.086075071395461 0.2389623217115766 4.776750710154356e-06 0.0013677912764436 1.4499148887765643e-10 1.3922453119695587e-14 1.3139357885669138e-15 +Proteasome 8 34 2.957728111905976 0.0030991534730493 10.895631067961164 35.30825242718446 0.6639562464102341 0.4930746972205201 6.290791570409542 1.0118856061679289 1.2857516091435552 0.3675316845524202 0.0023728758072474 0.0155575631698287 0.0061250241039257 3.475150315812665e-05 7.999759770652472e-05 +Epithelial cell signaling in helicobacter pylori infection 10 20 2.6364270972467656 0.0083784201603038 4.662621359223301 22.17233009708738 0.1577006728182372 0.6912327889750275 3.0418219058841363 2.9881499630566606 0.6220793917913584 0.2735025727899912 0.287065986663278 0.2145132052110039 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0.6140178987151432 2.957728111905976 0.0030991534730493 0.426277745653721 0.0695849121481971 34 P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P60900 8 +Epithelial cell signaling in helicobacter pylori infection 0.6743901911477306 2.6364270972467656 0.0083784201603038 0.7782168636288992 0.1499737208694394 20 Q16539,Q07157,P45985,Q9Y487,Q93050,Q15904,P36543,Q9Y624,P61421,Q06124 10 +Sphingolipid metabolism 0.8037065687554217 2.4837428859875743 0.0130009639899357 0.9039064138110968 0.2081269674395733 10 P16278,Q06136,P06280,P04062 4 +Steroid biosynthesis 0.8043465189220834 2.2511959326185247 0.0243731304072627 0.987927652625268 0.3089254448742493 8 P48449,Q15392,Q16850 3 +Glycosaminoglycan degradation 0.8507023040888188 2.1718882643195707 0.029864091882652 0.9956042624447972 0.3341045279371697 6 P54802,P08236,P06865 3 +Metabolism of xenobiotics by cytochrome p450 0.7859585930235738 2.0741573990292284 0.0380646952286187 0.9990381447236614 0.3342159324611922 7 P78417,P07099 2 +Calcium signaling pathway 0.6256902077223729 2.0129096198101935 0.0441241383684758 0.9996896387113904 0.3590100349071443 15 P21796 1 +Other glycan degradation 0.7490309261429812 1.9098471026490087 0.0561529025429672 0.9999678341979829 0.4370160676170058 7 P16278,Q9BTY2,P06865,P04062 4 +Chronic myeloid leukemia 0.6363527471542944 1.8539094031283967 0.0637521224125639 0.9999924323425016 0.4564651964739575 12 Q92769,P31751,Q13363,Q02750,P46109,Q06124 6 +Natural killer cell mediated cytotoxicity 0.586966539189945 1.7454932105244998 0.0808990532679527 0.9999997232961458 0.504195163602874 14 P10321,P04439,P15260,P01889,Q02750,P62993,Q06124 7 +Glutathione metabolism 0.5471619558365561 1.6813070148309646 0.0927032960505405 0.9999999726390838 0.53528677396925 18 P48735,O95881,P78417,O75874 4 +Porphyrin and chlorophyll metabolism 0.5734536598782531 1.506778556355465 0.131867427833501 0.9999999999898398 0.6471153837769998 12 P30519,P09601 2 +Tight junction 0.4412752549250975 1.5002422819013708 0.133551654402396 0.9999999999928232 0.6471153837769998 32 P51153,Q07157,P11802,P16989,P31751,P12814,P30153,Q14247,O43707,Q92797,Q9Y624,O14936,P11171,P30154 14 +Cell adhesion molecules cams 0.6405882646486565 1.4887216772277403 0.1365606743228862 0.9999999999961496 0.6471153837769998 8 P10321,Q9Y624,P01889,P04439 4 +Renal cell carcinoma 0.5330935675107723 1.4581513018655023 0.1447988433425244 0.9999999999993078 0.6569332912794158 15 Q15369,P31751,Q02750,P46109,Q06124 5 +Gap junction 0.5440972243904504 1.412472811724105 0.1578107906425412 0.9999999999999556 0.6569332912794158 13 Q9BVA1,Q07157,P68371,Q02750,P07437,P62993 6 +Colorectal cancer 0.561291516279763 1.373109959627119 0.1697181652897277 0.9999999999999966 0.6863681151455255 11 Q9UKG1,Q9UJX6,Q02750,P31751 4 +Drug metabolism cytochrome p450 0.64992017377145 1.3057396773840204 0.1916411000417524 1.0 0.6863681151455255 6 P78417 1 +Alpha linolenic acid metabolism 0.8373665480427062 1.2876854558604762 0.1978554784113486 1.0 0.6863681151455255 2 O15254 1 +Antigen processing and presentation 0.4996245176789955 1.2855563453874994 0.1985979403834501 1.0 0.6863681151455255 16 P10321,P01889,Q9UL46,P07858,P04439 5 +Renin angiotensin system 0.7976731076274819 1.2702469251020674 0.2039966873231795 1.0 0.6863681151455255 4 Q9UIQ6 1 +Graft versus host disease 0.790954415954401 1.2444808609641111 0.2133226390282607 1.0 0.6863681151455255 4 P10321,P01889,P04439 3 +Allograft rejection 0.790954415954401 1.2444808609641111 0.2133226390282607 1.0 0.6863681151455255 4 P10321,P01889,P04439 3 +Autoimmune thyroid disease 0.790954415954401 1.2444808609641111 0.2133226390282607 1.0 0.6863681151455255 4 P10321,P01889,P04439 3 +Viral myocarditis 0.5668908368366222 1.203730619218618 0.2286937136073072 1.0 0.6938334700967459 9 P01889,P04439 2 +Vibrio cholerae infection 0.4626354869212118 1.1692267958125506 0.2423122679056013 1.0 0.7228982659183774 19 Q07157,Q9Y487,Q93050,Q15904,P36543,P61421 6 +Glycerophospholipid metabolism 0.4782411842967092 1.0953690737862851 0.2733549772438337 1.0 0.7500901843275772 14 Q99943,P35790,Q8NCC3,Q8NF37 4 +Prostate cancer 0.4986082337037513 1.083990838025782 0.2783688611319856 1.0 0.7500901843275772 12 P31751,Q02750,P62993,P14625,P42345 5 +Notch signaling pathway 0.5708361614790919 1.0838776595585509 0.2784190462158549 1.0 0.7500901843275772 7 Q92542,Q13363,Q92769 3 +Endometrial cancer 0.5564159954714899 1.0793407566954505 0.2804358503444872 1.0 0.7500901843275772 8 Q9UJX6,Q02750,P31751 3 +Jak stat signaling pathway 0.5691924347626094 1.076129405884954 0.2818693860671182 1.0 0.7500901843275772 7 P15260,Q92783,Q06124 3 +Oxidative phosphorylation 0.3530332555019064 1.0570052579391598 0.2905091877885244 1.0 0.7500901843275772 55 P21912,O43676,Q9Y487,Q93050,Q15904,O75306,P47985,P36543,O75964 9 +Gnrh signaling pathway 0.5341613236424805 1.0379942281869576 0.2992727422222725 1.0 0.7500901843275772 9 P62993,Q02750,P45985 3 +Erbb signaling pathway 0.4944660576479915 1.0054119720046792 0.3146985174415104 1.0 0.7500901843275772 11 P45985,P31751,Q02750,P46109,P42345 5 +Thyroid cancer 0.540486983940935 1.0016481145320022 0.3165135741884235 1.0 0.7500901843275772 8 Q92734,Q02750 2 +Glycosphingolipid biosynthesis ganglio series 0.813129830893016 0.9912336515609418 0.3215715021662326 1.0 0.7500901843275772 3 P06865 1 +Glycosphingolipid biosynthesis globo series 0.807767811687263 0.972010372046492 0.3310453886138469 1.0 0.7500901843275772 3 P06865 1 +Neurotrophin signaling pathway 0.391087783209236 0.954888336081468 0.3396341688566036 1.0 0.7599314528166505 24 P31751,Q02750,Q99523,P62993,P46109,Q06124 6 +Cytokine cytokine receptor interaction 0.7881887581621543 0.9022866530943112 0.3669046137454297 1.0 0.791039170502333 3 P15260 1 +Melanoma 0.5316039862798982 0.8995691129592516 0.3683496005261215 1.0 0.791039170502333 7 P31751 1 +Fc epsilon ri signaling pathway 0.5056561014582597 0.8942018316556513 0.3712139124145026 1.0 0.791039170502333 9 P62993,Q02750,P45985,P31751 4 +Folate biosynthesis 0.7786775493307629 0.868720177628587 0.3850002022085519 1.0 0.7942136659699243 3 Q92820 1 +Starch and sucrose metabolism 0.4388767187000679 0.8587990148302228 0.3904514112030912 1.0 0.7942136659699243 14 P10253,P08236,P35573 3 +Parkinsons disease 0.3452925315081597 0.830192351188007 0.406430039098721 1.0 0.8083441888741228 49 P21912,O43676,P21796,P45880,O75306,P47985 6 +Type i diabetes mellitus 0.5908002282924297 0.8202159049124437 0.4120930365671928 1.0 0.8106005884123905 5 P01889,P04439 2 +Progesterone mediated oocyte maturation 0.3636146211270734 0.8059342819099352 0.4202807430460895 1.0 0.8177201413614134 25 Q16539,Q9UJX4,P31751,Q9UJX6,Q02750,Q13042,Q9UJX3,Q9UJX2 8 +Long term depression 0.4748668571424371 0.7408541903587443 0.4587818537661399 1.0 0.8736377853631813 9 Q02750,P30154 2 +O glycan biosynthesis 0.642307755144548 0.6875215906157996 0.4917540999162857 1.0 0.8979910360279405 4 Q86SF2,O43505 2 +Nod like receptor signaling pathway 0.4813364023319244 0.6683098115150625 0.5039358516571848 1.0 0.8979910360279405 7 Q16539,Q15750,P14625 3 +B cell receptor signaling pathway 0.4700884401000542 0.6640689795656917 0.5066461630670318 1.0 0.8979910360279405 8 Q02750,P31751 2 +Riboflavin metabolism 0.5426788415451571 0.6302522002358122 0.528529591313105 1.0 0.90101711280996 5 P11117,Q9NPH0 2 +Galactose metabolism 0.4014018772715427 0.589065611115369 0.5558172610972334 1.0 0.9298251377234092 13 P16278,P06280 2 +Glycosylphosphatidylinositol gpi anchor biosynthesis 0.6085648404127405 0.5699385685010678 0.568719364651884 1.0 0.9348891125888832 4 Q96S52,O43292 2 +Dorso ventral axis formation 0.6383144444897946 0.4149395851629893 0.6781861304748786 1.0 0.9766001400437012 3 Q02750 1 +Leishmania infection 0.4124573880872098 0.4065800706070627 0.6843164370854933 1.0 0.9766001400437012 8 Q15750,P15260 2 +Vascular smooth muscle contraction 0.3704677581082346 0.3887132103930705 0.6974883089479591 1.0 0.9766001400437012 12 P62136,P60660,Q02750 3 +Toll like receptor signaling pathway 0.3846029862225763 0.3702295259168857 0.711211478672896 1.0 0.9766001400437012 10 Q15750,Q02750,P45985,P31751 4 +Cell cycle 0.3005675983706583 0.3665408646638242 0.713961525444764 1.0 0.9766001400437012 47 P78527,Q9UJX4,O60566,Q9Y3B8,P11802,Q92769,Q9UBD5,Q9UJX6,Q13416,P63208,O60216,Q9Y619,Q13042,Q9UJX3,Q9H1A4,Q9UJX2,P30260 17 +Vegf signaling pathway 0.3696551514299402 0.3542461677964351 0.7231544070338103 1.0 0.9766001400437012 11 Q02750,P04792,P31751 3 +Hedgehog signaling pathway 0.6117478832598244 0.3427479325018304 0.7317880995351542 1.0 0.9766001400437012 3 P48729 1 +Mtor signaling pathway 0.3884696599566715 0.3406175118985161 0.7333915444164585 1.0 0.9766001400437012 9 P23588,P42345,P31751 3 +Tgf beta signaling pathway 0.4006001445026262 0.3284622957383631 0.7425621479276914 1.0 0.977342827051888 7 P30153,P30154 2 +T cell receptor signaling pathway 0.3580015325708298 0.3012603282987063 0.7632159898824702 1.0 0.991119074303472 11 P62993,Q02750,P31751 3 +Oocyte meiosis 0.2974943563976899 0.3000972543117943 0.7641029734853582 1.0 0.991119074303472 38 Q9UJX4,P62136,Q9UJX6,P30153,P63208,Q9H2G2,Q02750,Q13042,Q9UJX3,Q9H1A4,Q9UJX2,P30260,P30154 13 +Biosynthesis of unsaturated fatty acids 0.369571174354022 0.2377952944543017 0.812039868484548 1.0 1.0 8 Q9BY49,O15254 2 +P53 signaling pathway 0.3392598531153215 0.2210903652908232 0.8250220720295312 1.0 1.0 11 P11802,Q9Y3B8,P49327,O96017,P31350 5 +Glioma 0.3342884711646545 0.2009905367286282 0.8407059736770266 1.0 1.0 11 Q02750,P42345,P31751 3 +Glycine serine and threonine metabolism 0.3569637289576877 0.1760294834541135 0.8602707796527684 1.0 1.0 7 P34897,P23378 2 +Non small cell lung cancer 0.3451612183542275 0.1545253900443884 0.8771954932822998 1.0 1.0 8 Q02750,P31751 2 +Hypertrophic cardiomyopathy hcm 0.3121154460065038 0.0908744841964187 0.92759232494678 1.0 1.0 10 P54619,P09493,P50402,Q13131 4 +Bladder cancer 0.4176506333477059 0.0820182132929803 0.9346322301376244 1.0 1.0 4 Q02750 1 +Peroxisome 0.2612788126097306 0.0748494876051895 0.9403344668028456 1.0 1.0 27 O75874,Q15067,O00116,O15254,Q9BY49,P48735 6 +Huntingtons disease 0.2600364558816387 0.0642892200053767 0.9487399368884016 1.0 1.0 73 P21912,P42858,O43676,P21796,P45880,O75306,P47985 7 +Type ii diabetes mellitus 0.3096935138987825 0.0332060810166686 0.9735102488481866 1.0 1.0 6 P28482,P52789,O14654,P14618,P42345 5 diff --git a/msigdb_kegg/selections.json b/msigdb_kegg/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..e895f1271a840af64ed6c64de3aa21d3fabb00c3 --- /dev/null +++ b/msigdb_kegg/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Abc transporters", "Acute myeloid leukemia", "Adherens junction", "Adipocytokine signaling pathway", "Alanine aspartate and glutamate metabolism", "Aldosterone regulated sodium reabsorption", "Allograft rejection", "Alpha linolenic acid metabolism", "Alzheimers disease", "Amino sugar and nucleotide sugar metabolism", "Aminoacyl trna biosynthesis", "Amyotrophic lateral sclerosis als", "Antigen processing and presentation", "Apoptosis", "Arachidonic acid metabolism", "Arginine and proline metabolism", "Arrhythmogenic right ventricular cardiomyopathy arvc", "Ascorbate and aldarate metabolism", "Autoimmune thyroid disease", "Axon guidance", "B cell receptor signaling pathway", "Basal cell carcinoma", "Basal transcription factors", "Base excision repair", "Beta alanine metabolism", "Biosynthesis of unsaturated fatty acids", "Bladder cancer", "Butanoate metabolism", "Calcium signaling pathway", "Cardiac muscle contraction", "Cell adhesion molecules cams", "Cell cycle", "Chemokine signaling pathway", "Chronic myeloid leukemia", "Citrate cycle tca cycle", "Colorectal cancer", "Cysteine and methionine metabolism", "Cytokine cytokine receptor interaction", "Cytosolic dna sensing pathway", "Dilated cardiomyopathy", "Dna replication", "Dorso ventral axis formation", "Drug metabolism cytochrome p450", "Drug metabolism other enzymes", "Ecm receptor interaction", "Endocytosis", "Endometrial cancer", "Epithelial cell signaling in helicobacter pylori infection", "Erbb signaling pathway", "Ether lipid metabolism", "Fatty acid metabolism", "Fc epsilon ri signaling pathway", "Fc gamma r mediated phagocytosis", "Focal adhesion", "Folate biosynthesis", "Fructose and mannose metabolism", "Galactose metabolism", "Gap junction", "Glioma", "Glutathione metabolism", "Glycerolipid metabolism", "Glycerophospholipid metabolism", "Glycine serine and threonine metabolism", "Glycolysis gluconeogenesis", "Glycosaminoglycan biosynthesis chondroitin sulfate", "Glycosaminoglycan biosynthesis heparan sulfate", "Glycosaminoglycan biosynthesis keratan sulfate", "Glycosaminoglycan degradation", "Glycosphingolipid biosynthesis ganglio series", "Glycosphingolipid biosynthesis globo series", "Glycosphingolipid biosynthesis lacto and neolacto series", "Glycosylphosphatidylinositol gpi anchor biosynthesis", "Glyoxylate and dicarboxylate metabolism", "Gnrh signaling pathway", "Graft versus host disease", "Hedgehog signaling pathway", "Hematopoietic cell lineage", "Histidine metabolism", "Homologous recombination", "Huntingtons disease", "Hypertrophic cardiomyopathy hcm", "Inositol phosphate metabolism", "Insulin signaling pathway", "Jak stat signaling pathway", "Leishmania infection", "Leukocyte transendothelial migration", "Limonene and pinene degradation", "Long term depression", "Long term potentiation", "Lysine degradation", "Lysosome", "Mapk signaling pathway", "Melanogenesis", "Melanoma", "Metabolism of xenobiotics by cytochrome p450", "Mismatch repair", "Mtor signaling pathway", "N glycan biosynthesis", "Natural killer cell mediated cytotoxicity", "Neuroactive ligand receptor interaction", "Neurotrophin signaling pathway", "Nicotinate and nicotinamide metabolism", "Nitrogen metabolism", "Nod like receptor signaling pathway", "Non homologous end joining", "Non small cell lung cancer", "Notch signaling pathway", "Nucleotide excision repair", "O glycan biosynthesis", "Olfactory transduction", "One carbon pool by folate", "Oocyte meiosis", "Other glycan degradation", "Oxidative phosphorylation", "P53 signaling pathway", "Pancreatic cancer", "Pantothenate and coa biosynthesis", "Parkinsons disease", "Pathogenic escherichia coli infection", "Pathways in cancer", "Pentose and glucuronate interconversions", "Pentose phosphate pathway", "Peroxisome", "Phenylalanine metabolism", "Phosphatidylinositol signaling system", "Porphyrin and chlorophyll metabolism", "Ppar signaling pathway", "Primary bile acid biosynthesis", "Primary immunodeficiency", "Prion diseases", "Progesterone mediated oocyte maturation", "Propanoate metabolism", "Prostate cancer", "Proteasome", "Protein export", "Proximal tubule bicarbonate reclamation", "Purine metabolism", "Pyrimidine metabolism", "Pyruvate metabolism", "Regulation of actin cytoskeleton", "Regulation of autophagy", "Renal cell carcinoma", "Renin angiotensin system", "Retinol metabolism", "Riboflavin metabolism", "Ribosome", "Rig i like receptor signaling pathway", "Rna degradation", "Rna polymerase", "Selenoamino acid metabolism", "Small cell lung cancer", "Snare interactions in vesicular transport", "Sphingolipid metabolism", "Spliceosome", "Starch and sucrose metabolism", "Steroid biosynthesis", "Steroid hormone biosynthesis", "Sulfur metabolism", "Systemic lupus erythematosus", "T cell receptor signaling pathway", "Taste transduction", "Terpenoid backbone biosynthesis", "Tgf beta signaling pathway", "Thyroid cancer", "Tight junction", "Toll like receptor signaling pathway", "Tryptophan metabolism", "Type i diabetes mellitus", "Type ii diabetes mellitus", "Tyrosine metabolism", "Ubiquitin mediated proteolysis", "Valine leucine and isoleucine biosynthesis", "Valine leucine and isoleucine degradation", "Vascular smooth muscle contraction", "Vasopressin regulated water reabsorption", "Vegf signaling pathway", "Vibrio cholerae infection", "Viral myocarditis", "Wnt signaling pathway"], "available_proteins": ["AACS", "AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ACAA2", "ACACA", "ACACB", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT8", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTN1", "ACTN4", "ADAR", "ADH5", "ADI1", "ADK", "ADSL", "ADSS", "AFDN", "AGK", "AGL", "AGPAT1", "AGPS", "AHCY", "AHCYL1", "AIFM1", "AK1", "AK2", "AK3", "AKR1A1", "AKR1B1", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG5", "ALYREF", "AMPD2", "ANAPC1", "ANAPC2", "ANAPC5", "ANAPC7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEX1", "APPL1", "APRT", "AQR", "ARFGAP1", "ARFGAP2", "ARG2", "ARHGDIA", "ARHGEF2", "ARHGEF7", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ATIC", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "B3GALT6", "B4GAT1", "BAIAP2", "BCAS2", "BDH2", "BIRC6", "BLVRA", "BLVRB", "BNIP1", "BPNT1", "BUB1B", "BUB3", "BUD31", "CAB39", "CACNA2D1", "CACYBP", "CAD", "CALD1", "CALR", "CAMK2G", "CANX", "CAPN1", "CAPN2", "CARS", "CASK", "CBR1", "CCDC6", "CCNB1", "CCNB2", "CD47", "CDC16", "CDC23", "CDC27", "CDC42", "CDC5L", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDS2", "CFL1", "CFL2", "CHEK2", "CHERP", "CHKA", "CHMP2A", "CHMP2B", "CHMP4B", "CHMP5", "CHMP6", "CHORDC1", "CKB", "CKMT1A*", "CLN5", "CLTA", "CLTB", "CLTC", "CMAS", "CMPK1", "CNOT1", "CNOT7", "CNOT9", "COMT", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPOX", "CPT2", "CRKL", "CRNKL1", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CTBP1", "CTBP2", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC15", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DARS", "DARS2", "DBT", "DCPS", "DCTN1", "DCTN2", "DCTN4", "DCXR", "DDB1", "DDOST", "DDX23", "DDX39B", "DDX3X", "DDX42", "DDX46", "DDX5", "DDX6", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX38", "DHX8", "DIAPH1", "DIAPH3", "DIS3", "DLAT", "DLD", "DLST", "DNM1L", "DNM2", "DNMT1", "DOCK1", "DPM1", "DPYSL2", "DSG2", "DSP", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHS1", "ECI1", "ECI2", "EDC4", "EEA1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EI24", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "ELOB", "ELOC", "EMD", "ENAH", "ENDOD1", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPHX1", "EPHX2", "EPRS", "EPS15", "ERCC2", "ERCC3", "ERCC4", "ERO1A", "EXO1", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FAH", "FAR1", "FARP2", "FARSA", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FECH", "FEN1", "FH", "FLAD1", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FUCA1", "FUCA2", "G6PD", "GAA", "GABARAPL2", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GAMT", "GANAB", "GAPDH", "GARS", "GART", "GBA", "GCAT", "GCDH", "GCLM", "GFPT1", "GGA2", "GGCT", "GGH", "GLA", "GLB1", "GLDC", "GLG1", "GLO1", "GLS", "GLUD1", "GM2A", "GMDS", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNG5", "GNPAT", "GNPDA1", "GNS", "GOT1", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPI", "GRB2", "GRHPR", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GTF2F1", "GTF2I", "GUSB", "GYS1", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADH", "HADHA", "HADHB", "HDAC1", "HDAC2", "HEXA", "HEXB", "HGS", "HIBADH", "HIBCH", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HMBS", "HMGB1", "HMGCR", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA1", "HNRNPA3", "HNRNPC", "HNRNPK", "HNRNPM", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HTT", "HUWE1", "IARS", "IARS2", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFNGR1", "IGF1R", "IGF2BP1", "IGF2R", "IMPDH2", "IQGAP1", "IQGAP2", "IQSEC1", "IRS4", "ISYNA1", "ITCH", "ITGB1", "ITPA", "ITPK1", "IVD", "JUP", "KARS", "KDSR", "LAMP1", "LAP3", "LARS", "LARS2", "LCLAT1", "LDHA", "LDHB", "LIG3", "LLGL1", "LMNA", "LNPEP", "LPCAT1", "LPGAT1", "LRP1", "LSM2", "LSM4", "LSM6", "LSM7", "LSM8", "LSS", "LTA4H", "LYPLA1", "M6PR", "MAD2L1", "MANBA", "MAP2K1", "MAP2K4", "MAPK1", "MAPK14", "MARCKS", "MARCKSL1", "MARS", "MAT2A", "MAT2B", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "ME2", "MFSD8", "MGAT1", "MGST3", "MID1", "MIF", "MOGS", "MPG", "MPI", "MPST", "MRE11", "MRPL13", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTAP", "MTCH1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTMR6", "MTOR", "MTR", "MUT", "MYH10", "MYH9", "MYL6", "MYL6B", "NAE1", "NAGLU", "NAMPT", "NANS", "NARS", "NCBP1", "NCKAP1", "NCL", "NCSTN", "ND1", "NDUFA10", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA9", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV2", "NEDD4L", "NEFM", "NF1", "NIT2", "NLN", "NME1", "NNT", "NPC1", "NPC2", "NSD2", "NSDHL", "NSF", "NT5C2", "NUDT12", "NUDT5", "NUDT9", "OAT", "OCRL", "OGDH", "ORC2", "ORC3", "ORC5", "OXA1L", "OXCT1", "P4HA1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PAPSS2", "PARK7", "PARN", "PARP1", "PC", "PCBP1", "PCCA", "PCCB", "PCK2", "PCNA", "PDCD6", "PDCD6IP", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PECR", "PEX14", "PEX19", "PFAS", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PHF5A", "PHGDH", "PI4KA", "PIGK", "PIGS", "PIGT", "PIK3C2A", "PIK3R4", "PKM", "PLA2G15", "PLCG1", "PLK1", "PLOD1", "PLOD2", "PLRG1", "PMPCA", "PNP", "PNPT1", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR3A", "POLR3B", "POLR3C", "PPA1", "PPA2", "PPAT", "PPID", "PPIH", "PPIL1", "PPOX", "PPP1CA", "PPP1CB", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP5C", "PPT1", "PPT2", "PRDX5", "PRDX6", "PRIM1", "PRIM2", "PRKAA1", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKDC", "PRPF19", "PRPF3", "PRPF31", "PRPF38A", "PRPF38B", "PRPF4", "PRPF40A", "PRPF6", "PRPF8", "PRSS3", "PSAP", "PSAT1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PTGES2", 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0.3703499256790007 0.0177013554813805 0.0227338462584042 0.0615495803785245 0.00029508377291 0.0004519634212984 +Ub specific processing proteases 18 69 3.233232801832424 0.0012239777492784 17.070388349514563 72.1116504854369 0.5586830572298067 0.5701992170768696 9.734454714417684 6.256038651254875 1.0924507106168106 0.3735968680377643 0.0037242720299137 0.0062766857204869 0.0150493112681476 0.0002871967254038 4.01261957807159e-05 +Regulation of mrna stability by proteins that bind au rich elements 23 61 3.1980581462522326 0.0013835637985957 17.303398058252426 62.189320388349515 0.3637537395774206 0.6066390862029128 8.19973289328142 2.9201480419101515 1.0954480785949263 0.3602041660944462 0.0168987507290138 0.0571768496395965 0.0402942577421927 0.0006100016710547 4.528178354319885e-09 +Dna replication pre initiation 13 59 3.111865444543616 0.0018590921409067 16.987864077669904 61.73300970873787 0.4288945668380205 0.5957541730468855 9.845276246498855 3.587542857888571 1.230696609236802 0.3684137615844171 0.0036146518228741 0.0102615341834231 0.0117703691535426 7.074199918744216e-05 0.000129249341769 +Mapk family signaling cascades 17 79 3.1096458730819467 0.0018731176740571 23.104368932038835 88.2864077669903 0.366998662581797 0.5880023171217027 11.41393630950696 5.588694353030067 1.1675181672079205 0.3704838978698669 0.0032635384872778 0.003672822112265 0.0009692990734391 0.0018759447421988 0.0033757231245303 +Regulation of pten stability and activity 10 39 3.096925986539343 0.0019553868877837 12.611650485436892 41.82281553398058 0.6486618107800725 0.5229501310802542 7.056269001912706 2.1755846965350556 1.2659780846667748 0.3745012259374719 0.0091711121490462 0.0380696669646128 0.0225654450263633 0.0001261194405285 0.0001959957872258 +Auf1 hnrnp d0 binds and destabilizes mrna 14 40 3.020514737302009 0.0025234542745842 12.29126213592233 41.32281553398058 0.5322843325278358 0.5313716896545542 6.997407381130411 1.1321274049849332 1.2756329236795467 0.3681225669284069 0.004297419425316 0.0230307909850112 0.0108939889611676 0.0001382861626823 2.875155205352923e-07 +The role of gtse1 in g2 m progression after g2 checkpoint 11 46 2.993129904874263 0.0027613218764901 14.79611650485437 48.84466019417476 0.6226477470486884 0.5168095546238419 7.820323564061835 1.8499922936255029 1.3076695437390702 0.3722860732713196 0.0108504543285148 0.0425713267043903 0.0264876267470493 0.0011075917146321 7.825314737739928e-05 +Regulation of hmox1 expression and activity 11 43 2.9569190269667223 0.0031072970655019 12.524271844660197 45.58009708737864 0.7171016159839839 0.514573723238038 7.335701580194855 2.006274620945924 1.1938232298543638 0.3651188593292154 0.0073016248246482 0.0327224420542492 0.0022887430854204 6.924664655374279e-05 1.7329168891142377e-05 +Degradation of axin 9 35 2.955306668086396 0.0031235839708279 11.135922330097088 36.5 0.6371703324335989 0.5044883973483546 6.515923056292238 1.1005294401076644 1.2875505119575097 0.3689236351245595 0.004297419425316 0.0230307909850112 0.0108939889611676 0.0001382861626823 8.197910505732385e-05 +Cross presentation of soluble exogenous antigens endosomes 9 35 2.955306668086396 0.0031235839708279 11.097087378640778 36.91019417475728 0.6471378136535638 0.507052502601231 6.457500437861876 1.2421375880066114 1.2717860238430438 0.3672755762882163 0.0027408283935687 0.0171096007657598 0.0070463522145746 4.874947185003326e-05 1.908488484221945e-05 +Cellular response to hypoxia 10 38 2.9427608307431834 0.0032529962538068 12.067961165048544 40.00485436893204 0.522970313217548 0.5163863933875538 6.981963081004602 1.736242938617286 1.3015320227429066 0.3618367398400983 0.0076554117737869 0.0337662417977069 0.018985818871393 0.000511542389694 0.0001061774836938 +Sphingolipid metabolism 9 22 2.93124982763698 0.0033760116163761 11.00242718446602 26.135922330097088 1.1708540815039898 0.1757583754913391 4.192861933829232 2.1968580551223003 2.1941615995620167 0.2567064655985949 0.0675138603248962 0.2633971592089756 0.0216384292134882 1.5911917429603794e-05 0.0001690300981766 +Regulation of runx3 expression and activity 9 35 2.9283475975263404 0.0034076884554383 11.46359223300971 36.730582524271846 0.6696914114866416 0.4949350431730664 6.642474003130895 1.4202887203012589 1.288769965462232 0.3632605735082652 0.0053848592134802 0.0267403422938185 0.0135419734012732 0.0002314913891327 0.0001665225081846 +Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 18 46 2.9275590274989263 0.0034163420497053 14.026699029126211 48.65533980582524 0.5636343266746052 0.5641920682636952 7.183906351200202 2.917580729254371 1.1799230201059223 0.3753446211108022 0.0112962415814036 0.0437266531990119 0.0275216398495969 0.0012097891796545 9.091490665958128e-05 +Switching of origins to a post replicative state 20 58 2.9206106202513338 0.0034934615018769 16.810679611650485 58.20873786407767 0.6859740885709421 0.5709255515574044 8.560355820358037 3.2791073494099976 1.198149892515979 0.3860301174542495 0.0205028898701518 0.0650462755169659 0.0483217377147592 0.0009941384248502 0.0002122388464955 +Fceri mediated nf kb activation 10 38 2.9170820506984243 0.0035332281440842 13.599514563106796 43.58252427184466 0.43538002101356 0.532490131621357 7.591659945968655 2.4879291964009105 1.318650463428372 0.3690692407606546 0.0112962415814036 0.0437266531990119 0.0275216398495969 0.0012097891796545 0.0003919277181498 +Mitotic g1 phase and g1 s transition 19 70 2.900635421390038 0.0037240688339983 22.104368932038835 76.02184466019418 0.5927262006732629 0.5705780900762646 11.678595487596883 5.354610434747646 1.3736272695770486 0.3846948779804449 0.0750323277723813 0.1552273103013288 0.1585565307411962 0.0006745554526541 0.0005509149746255 +Interleukin 1 signaling 15 42 2.891976111300989 0.0038282705416468 13.79368932038835 46.30582524271845 0.5021606336105483 0.5332552544880472 7.891168652335007 2.7901813019255988 1.3195993763744758 0.3779352216468381 0.0186520481136078 0.0610672127355571 0.0442161560616649 0.0035695402472551 3.521476861973183e-05 +Stabilization of p53 9 37 2.8909146979077045 0.0038412236711287 11.759708737864075 38.849514563106794 0.5626554032387434 0.5211156380328503 6.862945949053685 1.536505541452464 1.2546862993954295 0.3691198814060923 0.0050990139544559 0.0257915242502586 0.0128487417044244 0.0002044748778434 0.0001404947310284 +Runx1 regulates transcription of genes involved in differentiation of hscs 10 40 2.883557120208131 0.0039321132760972 11.74514563106796 40.9247572815534 0.4838158037368226 0.5501011058260618 6.5789160679611225 1.5190277579548277 1.1933646193238052 0.3604187581137549 0.0011917305101277 0.0044455523824174 0.0040840095186766 0.0002170138050277 0.0003919277181498 +C type lectin receptors clrs 11 44 2.8832676684621426 0.0039357285360321 15.640776699029129 51.34708737864078 0.3190386727488686 0.5456940089786598 8.889127611188893 4.137023959900662 1.350649221433646 0.371203640545422 0.031224166582092 0.086158736226278 0.0714976342213511 0.0104482115740687 0.0032143698496569 +G1 s dna damage checkpoints 9 38 2.877497853893184 0.0040084263681834 12.276699029126211 40.3252427184466 0.5620621733571898 0.5261130346169095 7.080750657966309 1.8659034848764728 1.2552712987328345 0.3710523646543767 0.0083930286584374 0.0358926009784828 0.0207328276809773 0.0006279861154086 0.000641595952047 +Signaling by interleukins 33 99 2.8761302186284787 0.0040258359051581 26.51456310679612 106.8131067961165 0.2659215907627361 0.6379218100870152 12.507367985924851 6.646155400677433 1.0797762015608217 0.3618033258723105 0.090494727154452 0.1214587331935375 0.0098035647057395 0.0009852038872799 3.3720124621775446e-06 +Degradation of dvl 9 36 2.8720293268084576 0.0040784511661695 11.50728155339806 37.79611650485437 0.5954952616194853 0.5106657090472662 6.536116642578212 1.2295647923796569 1.2774118860610646 0.3695881914917919 0.0048225524960927 0.0248568883498602 0.0121763996061805 0.0001800616428063 0.0001179839212013 +Signaling by the b cell receptor bcr 11 42 2.8717235398985466 0.0040823993671923 14.0873786407767 45.66747572815534 0.5600618981864348 0.5194725240755018 7.669263829832862 3.2521255837555954 1.3165243686049508 0.3716278052198193 0.0244980696061782 0.0732573258319426 0.0570724957906687 0.0063342661912929 0.0014314583392422 +Cdt1 association with the cdc6 orc origin complex 10 39 2.8634644274258485 0.004190358630143 11.8373786407767 39.713592233009706 0.7088745358379469 0.5132999135100862 6.7665841522618235 1.8864642297262784 1.2345641700762902 0.3668156388656303 0.0059850441464068 0.0286799036387023 0.0149914480702132 4.084602018344024e-05 4.524440963497809e-05 +Clec7a dectin 1 signaling 11 42 2.855844649191033 0.0042922509448461 14.883495145631068 47.679611650485434 0.3802624296591366 0.5314258409805565 8.39359553685929 3.2641435107686965 1.369019650621671 0.3735312556615013 0.0205028898701518 0.0650462755169659 0.0483217377147592 0.0043610876134259 0.0007767330813302 +Downstream signaling events of b cell receptor bcr 10 40 2.8544153110353285 0.0043116125587741 13.109223300970871 42.81310679611651 0.5337893000107979 0.5120527765027618 7.35013455914348 2.784583610128895 1.330630298725885 0.3688632335833426 0.0126965853590611 0.0472622034410549 0.0307515849952898 0.0015612560180347 0.0005740731676286 +Asymmetric localization of pcp proteins 9 36 2.8522532149843465 0.0043410505263181 11.28883495145631 37.80825242718446 0.5764639774033125 0.5188050170985335 6.482730726459962 1.1863421199640956 1.2423982841678427 0.3682278814782295 0.0059850441464068 0.0286799036387023 0.0149914480702132 0.0002941476334404 0.0002308677663279 +Signaling by notch4 15 41 2.8470296961259707 0.0044129245628605 12.74271844660194 42.689320388349515 0.5846962923720355 0.527528574888472 7.095179574371064 1.5202779907622044 1.22282479858509 0.3678962187540617 0.0126965853590611 0.0472622034410549 0.0307515849952898 0.0015612560180347 0.0005740731676286 +Regulation of ras by gaps 9 37 2.829322751193488 0.0046646630718909 11.558252427184469 38.29611650485437 0.5949031665539309 0.5179046122727133 6.637200606991292 1.5039380235434 1.2829290056167597 0.3733028763215757 0.0069577649248468 0.0316917589218704 0.0173242512102645 0.0004129808075874 0.0003655904724143 +Mapk6 mapk4 signaling 14 46 2.82751452001502 0.0046910887979836 14.218446601941748 48.50728155339806 0.436374163749397 0.5681669850793678 8.12289402218768 1.923903139365317 1.248358570542089 0.3688600113322806 0.0157838838393127 0.0546342218360011 0.0377829414296325 0.0024989938189116 0.0011526515909172 +Metabolism of polyamines 9 37 2.8241554811816028 0.0047405382193506 11.783980582524272 38.49271844660194 0.5956280690899458 0.5058612771265996 6.813709458301494 1.1915745430318114 1.300721756016792 0.3709861514268986 0.004297419425316 0.0230307909850112 0.0108939889611676 0.0001382861626823 8.197910505732385e-05 +Degradation of beta catenin by the destruction complex 14 45 2.807065838712381 0.0049995022329814 14.8252427184466 48.63834951456311 0.4830095996380346 0.5534777326316677 8.029589918636947 2.025992551710678 1.2813542829769398 0.3757731368449524 0.0157838838393127 0.0546342218360011 0.0377829414296325 0.0005127634872309 0.000308468624942 +Fc epsilon receptor fceri signaling 12 46 2.802314092435147 0.005073744949021 16.155339805825243 52.529126213592235 0.3577248991718689 0.5588293080975716 8.909749521452186 4.003836293074435 1.3201566724870089 0.369825714615891 0.0379358997501139 0.0981576694070633 0.0855550276988868 0.0154968415322929 0.0021436695302957 +Apc c mediated degradation of cell cycle proteins 18 54 2.7957119366241345 0.0051785535296671 16.58009708737864 56.25970873786408 0.4894986081915347 0.5846445085026403 8.225929403640711 3.549651687085986 1.2134956516570392 0.3755323963670207 0.0180567941534335 0.0597604037758126 0.0428883183388871 0.0033316897742691 0.0004978062317691 +Transcriptional regulation by runx3 13 40 2.784668663248917 0.0053582445724988 12.155339805825244 41.550970873786405 0.5220991170779611 0.5409180415581131 7.051829317928235 1.9320556056256075 1.205315041796802 0.3587760476843317 0.0211415614529253 0.0663917661810799 0.0497306095082375 0.004652372899716 0.0085630435153123 +Disorders of transmembrane transporters 21 74 2.7837608376616783 0.0053732638608705 16.856796116504853 75.0 0.4823660391558403 0.6697743235347725 6.32312579601402 2.8163875505603726 0.7016136684862171 0.3381074424732327 0.0079506565861193 0.0186549140563941 0.0246695053344801 0.0004506920536562 3.693254793075409e-05 +Abc family proteins mediated transport 15 48 2.78298211893251 0.00538617745208 13.317961165048544 51.41990291262136 0.8313343047168666 0.503384351224866 6.603791770344115 3.017890343683211 1.0258838915302482 0.3681223740303289 0.014712034291434 0.0521335433076176 0.0353550186833354 0.0004284809943587 0.0009220641745238 +Hedgehog ligand biogenesis 9 38 2.7821032076041843 0.0054007862076073 11.735436893203884 40.279126213592235 0.705289766689403 0.5138056150617029 6.1754608769009325 1.552402214168598 1.168348102852658 0.3656259469969254 0.0056801747873364 0.027703186905031 0.0142561824639166 0.0002613122391266 0.0001964930706406 +Degradation of gli1 by the proteasome 9 39 2.775070187821133 0.0055189795677921 12.514563106796116 40.61407766990291 0.5405675752115602 0.5324758124461996 7.125251251124314 1.5545410691631658 1.272200728765061 0.3678115987415289 0.0056801747873364 0.027703186905031 0.0142561824639166 0.0002613122391266 0.0001964930706406 +Transcriptional regulation by runx1 23 64 2.754175255943047 0.0058840250696226 17.660194174757283 67.73058252427184 0.0956433719082077 0.6467498474297692 8.588831535590984 5.0191610185934845 0.9164516867594036 0.3343217460909707 0.0190749201232923 0.0363782758701844 0.0142770645433407 0.0032384967658702 0.0008831412078154 +Transcriptional regulation by runx2 11 48 2.749576213231613 0.0059672384257458 16.021844660194176 51.64320388349515 0.5147340657969439 0.5490234274922848 8.286848189022676 3.0091087328640205 1.321202711135219 0.3758826947187164 0.031224166582092 0.086158736226278 0.0714976342213511 0.0028229234797234 0.0010527524380771 +Hedgehog on state 9 39 2.748011576390281 0.0059957892099589 12.5752427184466 41.80339805825243 0.5567751925024539 0.5304257926517765 6.636298293339077 1.8972867972618663 1.2545866277969462 0.3643204702561447 0.0122192676461814 0.046072228335376 0.029653655190088 0.00143626842716 0.0019108778393583 +Tcf dependent signaling in response to wnt 16 56 2.737545631686082 0.0061899531949316 17.473300970873787 61.62378640776699 0.1854387909065221 0.5928765054134378 8.980116427159441 3.846157738891713 1.1264976241944151 0.36413626392076 0.0738076291046292 0.1535148843700442 0.1562534114898497 0.0074043156533507 0.0090244438763435 +Negative regulation of notch4 signaling 13 38 2.736340733798666 0.0062126660291506 12.218446601941748 39.786407766990294 0.5856668642754154 0.5088435203982538 7.300807876201572 1.1247479582770583 1.3003786017754655 0.3684988575140048 0.0045553852336327 0.0239365913087713 0.0115248505447769 0.0001580597168237 9.85983881561296e-05 +Cyclin a cdk2 associated events at s phase entry 10 40 2.717724343464727 0.0065732576347998 13.196601941747574 42.85679611650485 0.6136168472607347 0.5150313285959647 7.221373891468615 2.098630488986879 1.3159566032429193 0.3694066609952225 0.0168987507290138 0.0571768496395965 0.0402942577421927 0.0006100016710547 0.0014287535135353 +Hedgehog off state 11 46 2.7035628071569966 0.0068600482109302 15.740291262135925 51.0752427184466 0.6256619133963464 0.5308625548821857 8.054006294440956 2.7424510136822824 1.3127807939810612 0.3772173866259285 0.0281263938024935 0.0803423183551439 0.0648989212296417 0.0084325378638661 0.0022768192284096 +Defective cftr causes cystic fibrosis 12 40 2.697689936450463 0.0069822440666127 11.91019417475728 41.73300970873787 0.7347522269055131 0.5083451081080875 6.270921717387096 1.5205957155019303 1.1156147917216153 0.3576346657028889 0.0059850441464068 0.0286799036387023 0.0149914480702132 0.0002941476334404 0.0002308677663279 +Abc transporter disorders 12 40 2.697689936450463 0.0069822440666127 11.927184466019416 42.31310679611651 0.7277639006737601 0.5118740464528959 6.253118743036628 1.9845331695932795 1.1074811893524887 0.3608608076542074 0.0083930286584374 0.0358926009784828 0.0207328276809773 0.0006279861154086 0.000641595952047 +Tnfr2 non canonical nf kb pathway 9 39 2.682274087800744 0.0073123521658715 12.75242718446602 41.54126213592233 0.4835600067503021 0.5236768662797463 7.499311873418453 1.6207832096977548 1.329411623900184 0.3708129323396963 0.0073016248246482 0.0327224420542492 0.0181443698350236 0.0004601600061541 0.0004229506315236 +Dectin 1 mediated noncanonical nf kb signaling 9 39 2.682274087800744 0.0073123521658715 12.844660194174756 41.46116504854369 0.4840649810639716 0.5219757714388732 7.477483717709433 1.5951828582954857 1.3371619060105078 0.3706757674751831 0.0056801747873364 0.027703186905031 0.0142561824639166 0.0002613122391266 0.0001964930706406 +Cytokine signaling in immune system 52 165 2.6762379733942008 0.0074453758730546 40.29368932038835 173.29854368932038 -0.0419239880059683 0.7354133819481531 16.66208005117109 10.373402219489734 0.7729691766579994 0.321411905304117 0.0176099000058929 0.011827456040969 0.0043234607613845 8.502152010663247e-06 1.9685108813086985e-08 +Separation of sister chromatids 41 100 2.674925514727952 0.0074745854828115 27.25728155339806 104.59466019417476 0.1913519656937572 0.6759734454858931 10.904342253831215 7.99139528936842 0.9289444053822858 0.343574417926859 0.1247179491707237 0.218868634482452 0.2471395654652882 0.0040543858610966 5.586577559018581e-06 +Glycosphingolipid metabolism 6 13 2.6575193115681803 0.0078718080350319 7.514563106796117 15.521844660194176 0.6340330218232789 0.1371235236408302 2.3948329397108954 1.2175929202976112 2.2116324239586063 0.2290247571497847 0.203636451009126 1.0 0.0398064357050217 0.0001189444497952 0.0008647189955035 +Transport of small molecules 22 137 2.630879781077028 0.008516415588635 41.730582524271846 151.96601941747574 1.4265613612661356 0.380396759556163 14.87709311863932 12.598305121005488 1.746958952072276 0.4128488770716938 0.000231861823367 7.6666123702321e-05 0.0002522594661127 3.9980443747095845e-05 0.0052230744026753 +Glycerophospholipid biosynthesis 9 27 2.626434619566211 0.0086284566761976 9.439320388349516 29.58009708737864 1.1800609247564997 0.3081196451067344 4.809346434845489 4.094857299253986 1.3402414818469337 0.3224557628717913 1.0 1.0 0.0497306095082375 0.1537544245908172 0.0085630435153123 +Uch proteinases 10 43 2.6259068794469846 0.0086418455798344 12.934466019417476 45.69174757281554 0.4676332859413379 0.5268776688735902 7.345038379241775 2.489712786954197 1.2496925486564852 0.3629400025319104 0.0168987507290138 0.0571768496395965 0.0402942577421927 0.0006100016710547 0.0014287535135353 +Regulation of runx2 expression and activity 9 41 2.625184131986156 0.0086602120006562 13.184466019417476 42.609223300970875 0.5014097272359687 0.5334388394290158 7.623733474716015 1.80350585730159 1.3084091861848088 0.3700608446837968 0.0083930286584374 0.0358926009784828 0.0207328276809773 0.0006279861154086 0.000641595952047 +Interferon signaling 17 61 2.5799065859040056 0.009882704435272 16.961165048543688 63.04611650485437 -0.2449420514357405 0.7346768013010437 7.392166320809249 3.7829856018886088 0.5398140842888998 0.269547394488451 0.0576465798098153 0.0246789588609174 0.0346774200742129 0.0010441500645191 0.0013286688444077 +Pten regulation 20 59 2.579692753877915 0.0098888253788971 17.303398058252426 64.46601941747574 0.1876911775469084 0.6424585632708278 8.791141177940533 4.617012723077537 0.9726834868094096 0.3433123254029529 0.0576465798098153 0.1299869053709053 0.1252248136047773 0.0122330715468201 0.0036219089656112 +Scf skp2 mediated degradation of p27 p21 9 39 2.577617713119907 0.0099483990865023 12.78883495145631 40.70873786407767 0.5921499036968256 0.5162943652980111 7.12520288261254 1.2647657441579598 1.3047123749289669 0.3686628673319737 0.0059850441464068 0.0286799036387023 0.0149914480702132 0.0002941476334404 0.0002308677663279 +Orc1 removal from chromatin 10 49 2.570456112748099 0.0101564694701707 14.364077669902912 49.74757281553398 0.6917566411101944 0.5422658696614091 8.355189705990739 2.308567607855075 1.2721915859610031 0.3803308697876651 0.0099901163744135 0.0402962873689797 0.0244837275894334 0.0001576874873768 0.0002609651056342 +Iron uptake and transport 5 18 2.570176919387007 0.0101646589449104 4.089805825242719 17.9126213592233 1.0360420001787272 0.323786301352462 2.0477771422769826 0.9863810102632052 1.0014322629164618 0.2971986354372174 0.0278614928576642 0.0148056693212618 0.005693097574516 0.0002680304953179 0.0093317531476842 +Tcr signaling 9 41 2.566674394834253 0.0102678978344183 14.79368932038835 47.728155339805824 0.3776708616120087 0.5474588628929388 8.50292119881085 3.2417009042427978 1.3249802424411328 0.3685330173213761 0.0205028898701518 0.0650462755169659 0.0483217377147592 0.0043610876134259 0.0078989663196461 +Signaling by hedgehog 11 51 2.5530645350141823 0.0106779709441886 16.28640776699029 57.470873786407765 0.6189752673658386 0.5630638540633491 8.199307909979849 3.6419383260123857 1.1996921179618314 0.3729858641615031 0.0513041100135798 0.1201931014379405 0.1126980972536071 0.0281363706052967 0.0152610451604746 +Intracellular signaling by second messengers 26 74 2.5344682560612037 0.011261813015116 23.20145631067961 86.0631067961165 0.1421070399989671 0.655790329270176 10.291654542344736 8.129468035609259 0.948765500839012 0.3384114915870303 0.2149519113277893 0.3172349169334806 0.1859363131691987 0.0558849970455404 0.0346350200113349 +Signaling by insulin receptor 8 15 2.5117920766428417 0.0120119838673327 3.91504854368932 15.699029126213592 0.5754214954087689 0.534682491573688 2.331728544953775 1.4948776711085254 0.7798073838753424 0.3154925742571588 0.2670540153627264 0.1988423464133734 0.0693457394610891 0.000686888501954 0.020723717832043 +Cytoprotection by hmox1 13 60 2.4829806592422705 0.0130288161354894 15.264563106796116 64.83495145631068 0.939000341067099 0.4699320360831873 6.884300879212943 3.5957015529431366 1.0482386655891682 0.3835416044430508 0.0068111777937914 0.0165859501778065 0.004090384648508 0.0003149712375524 0.0002632378588678 +Interferon gamma signaling 8 13 2.474089789207013 0.0133576120864475 3.4174757281553396 12.29126213592233 0.3504356398232429 0.5841793314671695 2.235087678151022 1.9577134867833192 0.8232177003646645 0.3100303898066223 1.0 1.0 0.3896854720293997 0.0074685925596388 0.0110551101007063 +Ns1 mediated effects on host pathways 9 34 2.4613354631318702 0.0138420872338689 10.939320388349516 32.98300970873787 -0.1810967911548925 0.688491122847481 5.8925415688028675 1.4917906975653903 0.8146032678639678 0.3113724872920873 0.0025527432728967 0.0009649225463882 0.0065760397653667 0.0025916473916576 0.0005666628036471 +G2 m checkpoints 13 75 2.454299556040584 0.0141159336682266 20.961165048543688 83.21601941747574 0.2497590522742128 0.6198120617040068 11.249096904504546 6.6438113169442845 1.0983784482763044 0.3587806160447286 0.0643439224887299 0.1399625708529587 0.1382318498722026 0.0003883038979166 0.0054654584095901 +Mitochondrial protein import 6 31 2.427751065670092 0.0151927672454688 13.468446601941748 34.5873786407767 1.6025718162972953 0.1874419874946837 6.078090089851624 2.2108812815475147 1.8878681708577505 0.2901223460226844 0.0006976017751115 0.0001909592349294 0.0024373211620913 0.000511542389694 0.0020026076269409 +Interleukin 1 family signaling 13 45 2.4199775544278213 0.0155214651362396 14.592233009708735 49.06310679611651 0.4308069558259447 0.5378127516815151 8.12336542865419 3.453701835311694 1.3196847762251946 0.3781683305809454 0.0273790146030306 0.078908455169182 0.013122677075633 0.0020435025432918 4.827818755480527e-05 +Mitotic g2 g2 m phases 16 77 2.384639334793093 0.0170958726618384 25.512135922330096 89.70388349514563 0.5564324413272281 0.5721896286221594 11.374146646790262 7.343161700072858 1.2377579618165189 0.3831596446417351 0.0387309128616371 0.2315498527888138 0.1040156309725976 0.0146804600150792 0.0017198296119884 +Antigen processing cross presentation 13 47 2.3587355619364248 0.0183373175040815 13.364077669902912 51.03883495145631 0.6606344305939695 0.5456453275819227 6.483621701094183 2.525298521609755 1.0422529083240153 0.3659829171921698 0.001890755260844 0.0062917946367029 0.0063560749071577 1.4770683113528396e-05 1.6816524513897457e-05 +Host interactions of hiv factors 21 92 2.325364691076751 0.020052467835909 21.138349514563107 93.61407766990293 -0.0267805293071371 0.7872031403432971 10.354061404451876 2.6847458113641394 0.5558992957236051 0.2702067474339233 0.0081926763226174 0.0190851931940472 0.0253675472895287 0.0001086615195287 1.1075910406921447e-05 +Signaling by notch 18 53 2.2590045313606373 0.0238831030077164 14.941747572815531 58.85679611650485 0.4411392402814988 0.620198315051001 7.402538586762891 3.488034668926816 0.978025139431841 0.3518651286473304 0.0864570405209261 0.1708022529606737 0.1797395778178464 0.0308238027136821 0.0334710371325373 +Costimulation by the cd28 family 5 11 2.243985105492272 0.0248333596861112 4.839805825242719 13.96116504854369 0.124928035912034 0.6265426211311216 3.18881052802693 2.087514107141856 0.7549067311465592 0.2954089658345606 1.0 1.0 0.3143397790261298 0.0671599559498881 0.1190174178925116 +Transferrin endocytosis and recycling 7 11 2.224188112045158 0.0261357905489947 3.186893203883495 10.822815533980584 0.6564894823668704 0.3913498590234048 1.8751111444734605 0.7728172110534567 1.0012961103567426 0.2928480452979678 0.116715458993424 0.0847528009868792 0.1596960736798767 0.0007750266814789 0.0097510399506001 +Protein localization 22 65 2.1689048388507595 0.030089909310963 25.97087378640777 74.18203883495146 1.5594110758345356 0.2555609300308859 10.717199959161563 6.26233677332747 2.0947329132902324 0.3569924888492793 0.002859684290269 0.0006250933311618 0.0024184954955513 0.0001615199896828 5.409456628928887e-05 +Dna replication 24 84 2.148178386302626 0.0316995870276002 24.50242718446602 88.36650485436893 0.2923135263536031 0.6312906600612657 12.317305449092803 5.805851117746023 1.1877285197942282 0.3655243748981305 0.0144382934313027 0.0293962749000691 0.0428059841697078 0.0017480864507818 0.0009643504563797 +Insulin receptor recycling 5 10 2.1197948560331703 0.0340233493025687 2.8058252427184467 9.75485436893204 0.700482466018333 0.4255010129642833 1.8185038789646304 0.7947648660980334 0.8721431216225848 0.30442870747491 0.098240976313303 0.0711332726649859 0.1349531130589082 0.000366006536683 0.0048822579474643 +Cellular response to chemical stress 13 71 2.1135320830688684 0.034555251985026 16.92233009708738 74.85436893203884 0.6393995551476427 0.564482392286313 7.443234134196828 3.8890130701767585 0.935566980068825 0.3664371412566685 0.0130706023127143 0.0272445176770422 0.0090413964304997 0.0013987126889726 0.0019552407575785 +Mitophagy 2 12 2.1130934440265965 0.0345927707086326 3.662621359223301 11.783980582524272 1.3564301304992197 0.1917930287367771 1.8155907654273165 1.3363606860118669 1.2723890100166135 0.2636913304405313 0.0116325359304104 0.0060718409625537 0.0219975904219434 0.0193169154759243 0.0269295467729808 +Pyruvate metabolism 1 12 2.027252975216153 0.0426365479707451 3.929611650485437 15.470873786407768 0.216903571054168 0.5426656178372078 2.706948420656972 1.5847042582172477 0.8631836551211212 0.2863274944960451 0.0135775174792461 0.007105321595433 0.0255840399150975 0.1292409073430241 0.1298078118605267 +Glycosaminoglycan metabolism 7 13 2.0236730777645664 0.0430038004266746 6.563106796116505 14.388349514563108 0.750167459040055 0.1742505874253542 2.387954817808654 2.3973407990867264 1.8682770414846892 0.2409021330213527 0.3836145525598012 0.2919842266274133 0.1454623761357323 0.0266777247012389 0.0195970644320599 +Apoptosis 16 83 2.009143514344131 0.0445219160393517 22.723300970873787 88.14805825242719 0.0393529046833614 0.6051308661069602 11.01526481781096 5.029516867347871 1.0330743537895812 0.3410297528233371 0.0235726228805573 0.0427934356613144 0.0184179736538357 0.0004608452787455 0.0018138935206949 +Diseases of signal transduction by growth factor receptors and second messengers 39 127 2.0048328185290094 0.0449809227608668 38.23543689320388 143.25485436893203 0.0760803095091799 0.6705657643193705 15.041864122024071 11.50835917079556 0.9951358349988204 0.3506422537450402 0.0781511454543852 0.2233126855365551 0.1010569970097573 0.0599341973241276 0.0113192542080863 +S phase 24 89 1.9915827375325263 0.0464168589648763 25.58252427184466 94.497572815534 0.3936025929765626 0.6471527110395977 12.311904628033766 6.6662819095148595 1.1799446716032989 0.3778079902664983 0.0944619934499406 0.1813311010194401 0.194273291085049 0.0143012913315375 0.0042097246682284 diff --git a/msigdb_reactome/metrics.json b/msigdb_reactome/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..91d1e3f19829b730ac7bc85e4d8000fcb67a0b2e --- /dev/null +++ b/msigdb_reactome/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2812, + "annotations_size": 1372, + "title": "Average number of proteins per term", + "value": 17.831632653061224 +} \ No newline at end of file diff --git a/msigdb_reactome/paths.json b/msigdb_reactome/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..90df41d8097b63289949033f53b7d1f63aa408da --- /dev/null +++ b/msigdb_reactome/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_reactome/fragment/C428/C428_val_log2fc"} \ No newline at end of file diff --git a/msigdb_reactome/result.tsv b/msigdb_reactome/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..822d1ead176957d886e0b4c3ba34215deb38676e --- /dev/null +++ b/msigdb_reactome/result.tsv @@ -0,0 +1,516 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Deubiquitination 0.5209315055398197 3.381725302908378 0.0007203213628566 0.6279165123731527 0.0961689798948085 82 Q96FW1,P21796,P45880,P49721,Q9UPU5,Q8TEY7,P25788,P28072,P49720,P28074,Q92783,Q99436,Q9NXR7,Q15750,Q96K76,O75832,P20618,Q8NB78,O14964,P28070,P60900 21 +Ub specific processing proteases 0.5410380990923922 3.233232801832424 0.0012239777492784 0.8136867762125415 0.0961689798948085 69 Q96FW1,P25788,Q8TEY7,P28074,Q99436,O75832,P20618,O14964,P21796,P28072,P28070,P45880,P49721,Q15750,Q96K76,Q9UPU5,P60900,P49720 18 +Regulation of mrna stability by proteins that bind au rich elements 0.5514143605079885 3.1980581462522326 0.0013835637985957 0.8503661424966233 0.0961689798948085 61 Q01105,Q5RKV6,Q96B26,O00231,P49721,P39687,Q16539,P11940,P25788,Q92973,P28072,Q92945,P49720,P61289,P28074,Q99436,Q14103,O75832,P20618,P04792,P28070,Q9UL46,P60900 23 +Dna replication pre initiation 0.5452478166365695 3.111865444543616 0.0018590921409067 0.9221559902237964 0.0961689798948085 59 P25788,P28074,Q99436,P20618,P52294,P28072,P28070,Q9Y619,P49721,O60684,P60900,Q9NR33,P49720 13 +Mapk family signaling cascades 0.5058079675525607 3.1096458730819467 0.0018731176740571 0.923642371505163 0.0961689798948085 79 P30086,P30154,O75832,P25788,P28074,P20618,P49356,O60725,Q99436,O43924,P28072,P28070,Q14168,P49721,P60900,P49720,Q06124 17 +Regulation of pten stability and activity 0.6159918874575143 3.096925986539343 0.0019553868877837 0.9318072606742004 0.0961689798948085 39 P25788,P28074,Q99436,P20618,P31751,P28072,P28070,P49721,P60900,P49720 10 +Auf1 hnrnp d0 binds and destabilizes mrna 0.6032926777265492 3.020514737302009 0.0025234542745842 0.9687755848411 0.0961689798948085 40 Q14103,P11940,P25788,P28074,Q99436,O75832,P20618,P28072,P04792,P28070,P49721,Q9UL46,P60900,P49720 14 +The role of gtse1 in g2 m progression after g2 checkpoint 0.5785121435547068 2.993129904874263 0.0027613218764901 0.9774895119757284 0.0961689798948085 46 P25788,P28074,Q99436,P68371,P20618,P28072,P28070,P49721,Q9BVA1,P60900,P49720 11 +Regulation of hmox1 expression and activity 0.5855138921250501 2.9569190269667223 0.0031072970655019 0.9860161034688728 0.0961689798948085 43 Q8TCT9,P25788,P28074,Q99436,P20618,P28072,P09601,P28070,P49721,P60900,P49720 11 +Degradation of axin 0.6089971118100113 2.955306668086396 0.0031235839708279 0.9863260720325434 0.0961689798948085 35 P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P60900,P49720 9 +Cross presentation of soluble exogenous antigens endosomes 0.6089971118100113 2.955306668086396 0.0031235839708279 0.9863260720325434 0.0961689798948085 35 P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P60900,P49720 9 +Cellular response to hypoxia 0.5996004331247636 2.9427608307431834 0.0032529962538068 0.9885571006223922 0.0961689798948085 38 Q15369,P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P60900,P49720 10 +Sphingolipid metabolism 0.691574946146347 2.93124982763698 0.0033760116163761 0.9903396387340996 0.0961689798948085 22 P16278,P10619,P07602,P06280,O15270,Q06136,P06865,P04062,Q96G23 9 +Regulation of runx3 expression and activity 0.6055284520122639 2.9283475975263404 0.0034076884554383 0.990751859457934 0.0961689798948085 35 P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P60900,P49720 9 +Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 0.5709486996402422 2.9275590274989263 0.0034163420497053 0.9908613823807494 0.0961689798948085 46 Q9UJX4,O75832,P25788,P28074,Q99436,Q96DE5,P20618,Q9UJX6,P60900,P28072,P28070,O00231,P49721,Q9UL46,P49720,Q13042,Q9UJX3,Q9UJX2 18 +Switching of origins to a post replicative state 0.5269473210452563 2.9206106202513338 0.0034934615018769 0.9917819379803644 0.0961689798948085 58 Q9UBD5,O00231,P49721,Q9UJX2,P25788,P28072,Q13042,P49720,P28074,Q99436,Q96DE5,Q9Y619,Q9UJX3,Q9UJX4,O75832,P20618,Q9UJX6,P28070,Q9UL46,P60900 20 +Fceri mediated nf kb activation 0.5963909333200724 2.9170820506984243 0.0035332281440842 0.9922197986308848 0.0961689798948085 38 P25788,P28074,Q99436,P20618,P28072,P28070,P49721,Q15750,P60900,P49720 10 +Mitotic g1 phase and g1 s transition 0.5075898817709309 2.900635421390038 0.0037240688339983 0.9940177590904724 0.0961689798948085 70 Q9UBD5,P49721,Q9NR33,P25788,P28072,P49720,P31350,P30154,P28074,Q99436,Q9Y619,O75832,P20618,P31751,P30153,P28070,Q9UL46,P00374,P60900 19 +Interleukin 1 signaling 0.5811698004282977 2.891976111300989 0.0038282705416468 0.9948174947242424 0.0961689798948085 42 O75832,P25788,P28074,Q99436,P45985,P20618,Q02750,P28072,P28070,P49721,Q15750,Q9UL46,P60900,Q13501,P49720 15 +Stabilization of p53 0.5958027047210565 2.8909146979077045 0.0038412236711287 0.9949091313335938 0.0961689798948085 37 P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P60900,P49720 9 +Runx1 regulates transcription of genes involved in differentiation of hscs 0.5864662150919633 2.883557120208131 0.0039321132760972 0.995508164666299 0.0961689798948085 40 P25788,P28074,Q99436,P20618,P28072,P28070,P49721,Q03164,P60900,P49720 10 +C type lectin receptors clrs 0.5732735323468511 2.8832676684621426 0.0039357285360321 0.995530477176451 0.0961689798948085 44 P25788,P28074,Q99436,O43865,P20618,P28072,P28070,P49721,Q15750,P60900,P49720 11 +G1 s dna damage checkpoints 0.5914605501131036 2.8774978538931837 0.0040084263681834 0.995956371365608 0.0961689798948085 38 P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P60900,P49720 9 +Signaling by interleukins 0.4503129238327651 2.8761302186284787 0.0040258359051581 0.9960521929749392 0.0961689798948085 99 P52597,P14174,P08670,O14979,O00231,Q13126,P49721,P04083,P62993,P22626,P25788,P11233,P28072,P46109,P49720,Q53EL6,P30154,P28074,Q99436,P45985,P78417,P09601,Q15750,Q13501,Q06124,O75832,Q07820,P20618,P30153,Q02750,P28070,Q9UL46,P60900 33 +Degradation of dvl 0.5959435228706187 2.8720293268084576 0.0040784511661695 0.9963282132507504 0.0961689798948085 36 P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P60900,P49720 9 +Signaling by the b cell receptor bcr 0.5787496476565552 2.8717235398985466 0.0040823993671923 0.99634813034571 0.0961689798948085 42 P25788,P28074,Q99436,O43865,P20618,P28072,P28070,P49721,P62942,P60900,P49720 11 +Cdt1 association with the cdc6 orc origin complex 0.586937244523857 2.8634644274258485 0.004190358630143 0.996852829057275 0.0961689798948085 39 P25788,P28074,Q99436,P20618,P28072,P28070,Q9Y619,P49721,P60900,P49720 10 +Clec7a dectin 1 signaling 0.5768557077513065 2.855844649191033 0.0042922509448461 0.9972650525111844 0.0961689798948085 42 P25788,P28074,Q99436,O43865,P20618,P28072,P28070,P49721,Q15750,P60900,P49720 11 +Downstream signaling events of b cell receptor bcr 0.582917072861966 2.8544153110353285 0.0043116125587741 0.9973370531955114 0.0961689798948085 40 P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P62942,P60900,P49720 10 +Asymmetric localization of pcp proteins 0.5934433742599541 2.8522532149843465 0.0043410505263181 0.9974429124261552 0.0961689798948085 36 P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P60900,P49720 9 +Signaling by notch4 0.5789814747112378 2.8470296961259707 0.0044129245628605 0.9976840400916924 0.0961689798948085 41 O75832,P25788,P28074,Q99436,P20618,Q92542,P28072,P28070,O00231,P49721,Q9Y6A5,Q9UL46,P60900,Q06330,P49720 15 +Regulation of ras by gaps 0.5880890678396086 2.8293227511934873 0.0046646630718909 0.9983630017446856 0.0961689798948085 37 P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P60900,P49720 9 +Mapk6 mapk4 signaling 0.5595064251797558 2.82751452001502 0.0046910887979836 0.9984215588631165 0.0961689798948085 46 O75832,P25788,P61289,P28074,Q99436,P20618,P28072,P04792,P28070,O00231,P49721,Q9UL46,P60900,P49720 14 +Metabolism of polyamines 0.5874442220918002 2.8241554811816028 0.0047405382193506 0.9985255697069167 0.0961689798948085 37 P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P60900,P49720 9 +Degradation of beta catenin by the destruction complex 0.5608553324223404 2.807065838712381 0.0049995022329814 0.9989682728267544 0.0961689798948085 45 O75832,P25788,P28074,Q99436,P20618,Q13363,P30153,P28072,P28070,P49721,Q9UL46,P60900,P49720,P30154 14 +Fc epsilon receptor fceri signaling 0.5566426070651476 2.802314092435147 0.005073744949021 0.999068670714342 0.0961689798948085 46 P25788,P28074,Q99436,O43865,P45985,P20618,P28072,P28070,P49721,Q15750,P60900,P49720 12 +Apc c mediated degradation of cell cycle proteins 0.5217623690142827 2.7957119366241345 0.0051785535296671 0.9991940073628888 0.0961689798948085 54 Q9UJX4,O75832,P25788,P28074,Q99436,Q96DE5,P20618,Q9UJX6,P60900,P28072,P28070,O00231,P49721,Q9UL46,P49720,Q13042,Q9UJX3,Q9UJX2 18 +Transcriptional regulation by runx3 0.5744665867096019 2.7846686632489175 0.0053582445724988 0.9993709361472772 0.0961689798948085 40 O75832,P25788,P28074,Q99436,P20618,P28072,P28070,O00231,P49721,Q9UL46,P60900,Q06330,P49720 13 +Disorders of transmembrane transporters 0.4889746751193191 2.7837608376616783 0.0053732638608705 0.99938383478308 0.0961689798948085 74 P55735,Q99567,O75477,P49721,P53985,P57740,P25788,P28072,P49720,Q9BW27,P28074,Q99436,Q9BTX1,O75832,P20618,Q8NFH4,P28070,P35613,Q9UL46,P60900,Q12769 21 +Abc family proteins mediated transport 0.5467592313038362 2.78298211893251 0.00538617745208 0.9993947135244524 0.0961689798948085 48 O75832,P25788,P28074,Q99436,P20618,P28072,O75477,O00231,P28070,P49721,P08183,Q9UL46,P40855,P60900,P49720 15 +Hedgehog ligand biogenesis 0.5796632364225652 2.7821032076041843 0.0054007862076073 0.9994067891161642 0.0961689798948085 38 P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P60900,P49720 9 +Degradation of gli1 by the proteasome 0.5761221197606666 2.775070187821133 0.0055189795677921 0.999496039231318 0.0961689798948085 39 P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P60900,P49720 9 +Transcriptional regulation by runx1 0.5035188662474233 2.754175255943047 0.0058840250696226 0.999695465597099 0.0968611112726662 64 O00231,P49721,Q03164,Q07157,P25788,P28072,P49720,Q99873,P61289,P28074,Q99436,Q8IXK0,Q969G3,Q96ST3,Q9HCE1,P17931,Q06124,O75832,P20618,Q99496,P28070,Q9UL46,P60900 23 +Transcriptional regulation by runx2 0.5430678204814232 2.7495762132316135 0.0059672384257458 0.9997285074271056 0.0968611112726662 48 P25788,P28074,Q99436,P20618,P31751,P28072,P28070,P49721,P60900,P49720,Q96PK6 11 +Hedgehog on state 0.5728314629288387 2.748011576390281 0.0059957892099589 0.9997389981771556 0.0968611112726662 39 P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P60900,P49720 9 +Tcf dependent signaling in response to wnt 0.5103018255927542 2.737545631686082 0.0061899531949316 0.9998003628727138 0.0968611112726662 56 O75832,P25788,P28074,Q99436,P20618,P31751,P40818,Q13363,P30153,P28072,P28070,P49721,Q9UL46,P60900,P49720,P30154 16 +Negative regulation of notch4 signaling 0.5740458070891332 2.736340733798666 0.0062126660291506 0.9998065256597086 0.0968611112726662 38 O75832,P25788,P28074,Q99436,P20618,P28072,P28070,O00231,P49721,Q9Y6A5,Q9UL46,P60900,P49720 13 +Cyclin a cdk2 associated events at s phase entry 0.5664132556984129 2.717724343464727 0.0065732576347998 0.9998824069357308 0.0977514169325784 40 P25788,P28074,Q99436,P20618,P31751,P28072,P28070,P49721,P60900,P49720 10 +Hedgehog off state 0.5454907687960171 2.7035628071569966 0.0068600482109302 0.9999208699528184 0.0977514169325784 46 P25788,P28074,Q99436,P68371,P20618,P28072,P28070,P49721,Q9BVA1,P60900,P49720 11 +Defective cftr causes cystic fibrosis 0.5640140041365101 2.697689936450463 0.0069822440666127 0.9999331620177296 0.0977514169325784 40 O75832,P25788,P28074,Q99436,P20618,P28072,O75477,P28070,P49721,Q9UL46,P60900,P49720 12 +Abc transporter disorders 0.5640140041365101 2.697689936450463 0.0069822440666127 0.9999331620177296 0.0977514169325784 40 O75832,P25788,P28074,Q99436,P20618,P28072,O75477,P28070,P49721,Q9UL46,P60900,P49720 12 +Tnfr2 non canonical nf kb pathway 0.564875582206775 2.682274087800744 0.0073123521658715 0.9999576443075764 0.1003254717157578 39 P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P60900,P49720 9 +Dectin 1 mediated noncanonical nf kb signaling 0.564875582206775 2.682274087800744 0.0073123521658715 0.9999576443075764 0.1003254717157578 39 P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P60900,P49720 9 +Cytokine signaling in immune system 0.4567495458017842 2.6762379733942008 0.0074453758730546 0.9999647580342008 0.1005405027687984 165 Q15369,P55735,P15260,Q99567,P52597,P14174,P08670,O14979,O00231,Q13126,P49721,P04083,P62993,Q14258,P57740,P22626,P04439,O00505,P25788,P11233,O00629,P52294,P01889,P28072,P46109,P49720,Q53EL6,P30154,P10321,O15344,Q9BW27,P28074,Q99436,P45985,P78417,P09601,Q15750,Q13501,Q06124,O75832,Q07820,P20618,P31751,Q9BTX1,P30153,Q8NFH4,Q02750,P28070,P19474,Q9UL46,P60900,Q12769 52 +Separation of sister chromatids 0.4357826662169125 2.6749255147279514 0.0074745854828115 0.9999661526473512 0.1005405027687984 100 P55735,P68371,Q92674,O60216,O00231,P49721,Q8WYP5,Q99661,Q9BUF5,Q9H1A4,Q9HBM1,Q9UJX2,P57740,O60566,P25788,P28072,Q13042,Q9Y266,P49720,P30154,Q8NI77,Q9BW27,P61289,P28074,Q99436,Q96DE5,Q9UJX3,Q7L7X3,Q9UJX4,O75832,P20618,Q9UJX6,P30153,Q8NFH4,P28070,Q8NBT2,Q9UL46,Q15691,Q9BVA1,P60900,Q12769 41 +Glycosphingolipid metabolism 0.7708671309117558 2.6575193115681803 0.0078718080350319 0.9999804562157912 0.1018879304156966 13 P16278,P10619,P07602,P06280,P06865,P04062 6 +Transport of small molecules 0.4477258180083505 2.6308797810770277 0.008516415588635 0.9999919879317202 0.1070433411252286 137 Q70HW3,P21796,Q9C0H2,P45880,P49721,P36543,P53985,P30519,Q8WTV0,Q9Y487,Q93050,P28072,Q9UBX3,P28074,Q99436,P09601,O15118,P08183,Q9HD20,P20618,P28070,P60900 22 +Glycerophospholipid biosynthesis 0.5944934698604409 2.626434619566211 0.0086284566761976 0.9999931386829336 0.1070433411252286 27 Q99829,Q8N2A8,Q8NF37,Q8IV08,Q9BZF1,Q9NPH0,Q8NCC3,Q99943,P35790 9 +Uch proteinases 0.5467325974679841 2.6259068794469846 0.0086418455798344 0.9999932646496084 0.1070433411252286 43 P25788,P28074,Q99436,P20618,Q8NB78,P28072,P28070,P49721,P60900,P49720 10 +Regulation of runx2 expression and activity 0.5525993965970147 2.6251841319861557 0.0086602120006562 0.9999934336954076 0.1070433411252286 41 P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P60900,P49720 9 +Interferon signaling 0.4904106769866896 2.5799065859040056 0.009882704435272 0.999998791964842 0.1137433628890103 61 O15344,P55735,O00505,P10321,Q9BW27,P15260,Q9BTX1,Q99567,O00629,P01889,P52294,Q8NFH4,P19474,P57740,Q12769,Q06124,P04439 17 +Pten regulation 0.4922947756390756 2.579692753877915 0.0098888253788971 0.999998802167804 0.1137433628890103 59 O00231,P49721,Q15022,P25788,P28072,P49720,P61289,P28074,Q99436,Q8IXK0,Q9HCE1,O75832,Q92769,P31751,P20618,P28070,O95983,Q9UL46,P60900,P42345 20 +Scf skp2 mediated degradation of p27 p21 0.5523208888671488 2.577617713119907 0.0099483990865023 0.9999988970819144 0.1137433628890103 39 P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P60900,P49720 9 +Orc1 removal from chromatin 0.5197106376392627 2.570456112748099 0.0101564694701707 0.9999991733814448 0.114310754691944 49 P25788,P28074,Q99436,P20618,P28072,P28070,Q9Y619,P49721,P60900,P49720 10 +Iron uptake and transport 0.6901090302257988 2.570176919387007 0.0101646589449104 0.9999991827115812 0.114310754691944 18 Q9Y487,Q93050,P09601,P36543,P30519 5 +Tcr signaling 0.5457410843877281 2.566674394834253 0.0102678978344183 0.999999291686856 0.1145329742180653 41 P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P60900,P49720 9 +Signaling by hedgehog 0.5099530437165619 2.5530645350141823 0.0106779709441886 0.9999995988596658 0.1162712391700542 51 P25788,P28074,Q99436,P68371,P20618,P28072,P28070,P49721,Q9BVA1,P60900,P49720 11 +Intracellular signaling by second messengers 0.4670275046662088 2.5344682560612033 0.011261813015116 0.9999998215345026 0.1178215447486349 74 O00231,P49721,P10644,P62993,Q15022,P25788,P28072,P49720,P30154,P61289,P28074,Q99436,O43865,Q8IXK0,Q9HCE1,Q06124,O75832,Q92769,P31751,P20618,P30153,P28070,O95983,Q9UL46,P60900,P42345 26 +Signaling by insulin receptor 0.713376140355682 2.5117920766428417 0.0120119838673327 0.9999999370057964 0.1223021452819988 15 P31751,Q9Y487,Q93050,Q15904,P36543,P62993,P61421,Q06124 8 +Cytoprotection by hmox1 0.4820986319800547 2.4829806592422705 0.0130288161354894 0.999999984663124 0.1304783630503031 60 Q8TCT9,P25788,P28074,Q99436,P20618,P28072,P09601,P28070,P49721,Q86X55,P60900,P49720,P30519 13 +Interferon gamma signaling 0.7355284989360369 2.474089789207013 0.0133576120864475 0.9999999902903433 0.1328017665406239 13 O15344,P10321,P15260,P01889,P19474,Q14258,Q06124,P04439 8 +Ns1 mediated effects on host pathways 0.5508702664298578 2.4613354631318702 0.0138420872338689 0.9999999950506484 0.1338673435138936 34 P55735,O00505,Q9BW27,Q9BTX1,O00629,P52294,Q8NFH4,P57740,Q12769 9 +G2 m checkpoints 0.4581645163882647 2.454299556040584 0.0141159336682266 0.999999996618861 0.1344934791167146 75 P25788,P28074,Q99436,P20618,P28072,Q9NXR7,Q9Y619,P28070,P49721,O96028,Q9UQ84,P60900,P49720 13 +Mitochondrial protein import 0.556917800030937 2.4277510656700914 0.0151927672454688 0.9999999992451044 0.1427703880875562 31 Q9Y512,Q9NS69,Q99595,O60830,P21796,Q5JRX3 6 +Interleukin 1 family signaling 0.5172648298878817 2.4199775544278213 0.0155214651362396 0.999999999522496 0.1448670079382367 45 O75832,P25788,P28074,Q99436,P45985,P20618,P28072,P28070,P49721,Q15750,P60900,P49720,Q06124 13 +Mitotic g2 g2 m phases 0.4482779381101531 2.384639334793093 0.0170958726618384 0.9999999999468736 0.1543127453423837 77 O94927,P25788,P20618,P28074,Q99436,P68371,P28072,P28070,P49721,O75935,P07437,Q9BVA1,P60900,P49720,O95684,P30154 16 +Antigen processing cross presentation 0.5041537255265276 2.3587355619364248 0.0183373175040815 0.999999999990619 0.1644365987947702 47 P10321,P25788,P28074,Q99436,P20618,P01889,P28072,P28070,P49721,Q9UIQ6,P60900,P49720,P04439 13 +Host interactions of hiv factors 0.4056994489681688 2.325364691076751 0.020052467835909 0.9999999999991483 0.1741264928535902 92 Q15369,P55735,Q99567,P49721,P57740,P04439,P25788,P52294,P28072,P49720,Q9BW27,P28074,Q99436,O75832,Q9BTX1,P20618,Q8NFH4,P28070,Q9UL46,P60900,Q12769 21 +Signaling by notch 0.4720443035129223 2.2590045313606373 0.0238831030077164 0.999999999999996 0.1927506901563939 53 P67809,O75832,P25788,P61289,P28074,Q99436,Q92542,Q92769,P20618,P28072,P28070,O00231,P49721,Q9Y6A5,Q9UL46,P60900,Q06330,P49720 18 +Costimulation by the cd28 family 0.7261125001615742 2.2439851054922717 0.0248333596861112 0.999999999999999 0.1992477747914888 11 P30154,P31751,P30153,P42345,Q06124 5 +Transferrin endocytosis and recycling 0.7222023517393802 2.224188112045158 0.0261357905489947 1.0 0.2072734371862472 11 P02786,Q9Y487,Q93050,Q15904,P36543,P21283,P61421 7 +Protein localization 0.4480631545679098 2.1689048388507595 0.030089909310963 1.0 0.2318195845832739 65 Q9NS69,Q8TB36,O75874,Q99595,O60830,P21796,Q10713,O14925,O15254,Q9BY49,Q5JRX3,P50402,Q9Y512,P46379,P51648,O43765,Q9NX63,Q13505,Q15067,P09601,O00116,Q8N4H5 22 +Dna replication 0.4138708441752179 2.148178386302626 0.0316995870276002 1.0 0.2402863723860083 84 Q9UBD5,O00231,P49721,Q9NR33,Q9UJX2,P25788,P52294,P28072,O60684,Q13042,P49720,P28074,Q99436,Q96DE5,Q9Y619,Q9UJX3,Q9Y2S7,Q9UJX4,O75832,P20618,Q9UJX6,P28070,Q9UL46,P60900 24 +Insulin receptor recycling 0.7279777291469963 2.1197948560331703 0.0340233493025687 1.0 0.2496258569151036 10 Q9Y487,Q93050,Q15904,P36543,P61421 5 +Cellular response to chemical stress 0.4356665411252066 2.1135320830688684 0.034555251985026 1.0 0.2500177486548909 71 Q8TCT9,P25788,P28074,Q99436,P20618,P28072,P09601,P28070,P49721,Q86X55,P60900,P49720,P30519 13 +Mitophagy 0.6846692874091048 2.1130934440265965 0.0345927707086326 1.0 0.2500177486548909 12 P21796,Q9NS69 2 +Pyruvate metabolism 0.6685226764053724 2.0272529752161534 0.0426365479707451 1.0 0.2730652089863393 12 P21796 1 +Glycosaminoglycan metabolism 0.651844108827758 2.0236730777645664 0.0430038004266746 1.0 0.2730652089863393 13 P16278,Q7LGA3,Q8TB61,O43505,P54802,P08236,P06865 7 +Apoptosis 0.4053813212507253 2.009143514344131 0.0445219160393517 1.0 0.2751534630900477 83 P30419,O75832,P25788,P28074,P20618,Q99436,Q9NR28,P31751,P52294,P08670,P28072,P28070,P49721,O60443,P60900,P49720 16 +Diseases of signal transduction by growth factor receptors and second messengers 0.400199709635878 2.0048328185290094 0.0449809227608668 1.0 0.2767436144749297 127 P30086,Q92734,Q13363,O00231,P49721,P10644,P62993,O95684,Q6UN15,Q16543,Q14789,P25788,P28072,P62942,Q6RW13,P51114,Q06330,P49720,P30154,P61289,P28074,Q99436,Q96PU8,Q92542,O15514,Q13501,Q9NRY5,Q06124,O43252,O75832,P20618,P31751,Q92769,P30153,Q02750,P28070,Q9UL46,P60900,P42345 39 +S phase 0.3898286955691213 1.9915827375325263 0.0464168589648763 1.0 0.2843032611598676 89 Q9UBD5,O60216,O00231,P49721,Q9NR33,Q9UJX2,P25788,P28072,Q13042,P49720,P28074,Q99436,Q96DE5,Q9Y619,Q9UJX3,Q9Y2S7,Q9UJX4,O75832,P20618,P31751,Q9UJX6,P28070,Q9UL46,P60900 24 +Selective autophagy 0.5062639775120693 1.9595222161398893 0.0500516607302887 1.0 0.2972765303980788 27 Q9BVA1,P21796,Q8N4H5,Q9NS69 4 +Ros and rns production in phagocytes 0.7168371778437785 1.9462469249001848 0.0516250856825466 1.0 0.3026906733181794 9 Q9Y487,Q93050,P61421,P36543 4 +Synthesis of pc 0.7934474401079648 1.9317822361759596 0.053386389523182 1.0 0.3091350951682547 6 P35790 1 +Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.7128258367980095 1.9269846379755555 0.0539815444372731 1.0 0.3098856860583209 9 Q9UJX4,Q96DE5,Q9UJX6,Q13042,Q9UJX3,Q9H1A4,Q9UJX2 7 +Negative regulation of met activity 0.7307466111707108 1.9156764562243376 0.0554062910250994 1.0 0.3141759720390221 8 O14964,P40818,Q92783 3 +Phospholipid metabolism 0.47391630145966 1.8983225280380145 0.0576536080911751 1.0 0.3215477654515947 39 Q99829,Q8N2A8,Q9Y217,Q8NF37,Q8IV08,Q9BZF1,Q9NPH0,Q8NCC3,Q99943,P42356,P35790 11 +Interferon alpha beta signaling 0.6821299130794002 1.8920023061156963 0.058490673545126 1.0 0.3226776441311579 10 P01889,Q06124,P04439 3 +Pink1 prkn mediated mitophagy 0.7038250950141565 1.8836237054869347 0.0596158929974275 1.0 0.3253923138438225 9 P21796,Q9NS69 2 +Synthesis of dna 0.402525817543701 1.870508710094292 0.0614132085992444 1.0 0.3304271458751507 79 Q9UBD5,O00231,P49721,Q9NR33,Q9UJX2,P25788,P28072,Q13042,P49720,P28074,Q99436,Q96DE5,Q9Y619,Q9UJX3,Q9Y2S7,Q9UJX4,O75832,P20618,Q9UJX6,P28070,Q9UL46,P60900 22 +Apc cdc20 mediated degradation of nek2a 0.6380764019525633 1.863273594060048 0.0624237832993586 1.0 0.3332507030611673 12 Q9UJX4,O60566,Q96DE5,Q9UJX6,Q13042,Q9UJX3,Q9H1A4,Q9UJX2 8 +Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components 0.6380764019525633 1.863273594060048 0.0624237832993586 1.0 0.3332507030611673 12 Q9UJX4,O60566,Q96DE5,Q9UJX6,Q13042,Q9UJX3,Q9H1A4,Q9UJX2 8 +Cholesterol biosynthesis 0.6068204900698032 1.861220327616746 0.0627130688892045 1.0 0.3334974051007313 14 Q16850,Q15392,P48449,Q9BWD1,Q15800 5 +Pcp ce pathway 0.4500030650514732 1.8425561315844432 0.0653938439112691 1.0 0.338310850228225 47 O75832,P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P60900,P49720 10 +Ras processing 0.7705575108245488 1.8340866878521855 0.0666411271633284 1.0 0.342440548569613 6 P49356,O43924 2 +Apc c cdc20 mediated degradation of cyclin b 0.6435872414347884 1.8168022421824923 0.0692473993877651 1.0 0.3519836166753276 11 Q9UJX4,Q96DE5,Q9UJX6,Q13042,Q9UJX3,Q9H1A4,Q9UJX2 7 +Keratan sulfate keratin metabolism 0.8336429324226065 1.8166683360789555 0.069267912902579 1.0 0.3519836166753276 5 P06865,O43505 2 +Beta catenin independent wnt signaling 0.4351825417901733 1.8115426814610016 0.0700568884140573 1.0 0.354679154627626 51 O75832,P25788,P28074,Q99436,P20618,P28072,P28070,P49721,P60900,P49720 10 +Signaling by braf and raf1 fusions 0.5334470020016228 1.791270391837799 0.0732499150153576 1.0 0.3654504850948023 21 P30086,Q96PU8,Q02750,Q6RW13,P51114 5 +Programmed cell death 0.3681461700422497 1.7705179432638558 0.0766408979782864 1.0 0.3782421295906798 95 Q16543,P30419,O75832,P25788,P28074,P20618,Q99436,Q9NR28,P31751,P52294,P08670,P28072,P28070,P49721,O60443,P60900,P49720 17 +Gpcr ligand binding 0.6983704373698761 1.7642300419302397 0.0776932567508363 1.0 0.3815736987308942 8 P04083,P07602,P42892 3 +Cell cycle checkpoints 0.3836423093626808 1.7515694800158994 0.0798478643600797 1.0 0.3898621704698555 129 P55735,Q9Y3B8,Q9UBD5,Q92674,O00231,P49721,O96028,Q8WYP5,Q99661,P57740,Q9H1A4,Q9UJX2,Q9HBM1,P25788,P28072,Q12888,Q13042,P49720,P30154,Q8NI77,Q9BW27,P61289,P28074,Q99436,Q96DE5,Q9NXR7,Q9Y619,Q9UJX3,Q7L7X3,Q9UJX4,O75832,P20618,Q9UJX6,P30153,Q8NFH4,P28070,Q8NBT2,Q9UL46,Q15691,Q9UQ84,P60900,Q12769 42 +Assembly and cell surface presentation of nmda receptors 0.7047446503546072 1.7091023403859535 0.0874319941509194 1.0 0.4174879366317177 7 P68371,Q9BVA1,O14936 3 +Platelet activation signaling and aggregation 0.4431267819585968 1.7056692368708124 0.088069680418148 1.0 0.4174879366317177 44 O43852,Q8NBX0,Q9NTK5,P07602,Q06481,Q13685,Q9NUQ9,Q06124 8 +Inlb mediated entry of listeria monocytogenes into host cell 0.7399638839042053 1.7020832823222696 0.0887397573252095 1.0 0.4174879366317177 6 O14964,Q92783 2 +Cd28 co stimulation 0.7398246094325819 1.7014787877757584 0.0888531177087912 1.0 0.4174879366317177 6 P42345,P31751 2 +Antigen presentation folding assembly and peptide loading of class i mhc 0.5777143608048422 1.6911601439502555 0.0908062208276121 1.0 0.4252086517934603 14 P10321,P55735,P01889,Q6P179,P04439 5 +Platelet homeostasis 0.6633664146992297 1.686407047202479 0.0917174250134136 1.0 0.4265637529437406 9 P30153,Q06124,P30154 3 +Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways 0.6985399681773153 1.6806745278754118 0.0928261508649899 1.0 0.4284560038233091 7 Q13685,Q15750,P09601 3 +Listeria monocytogenes entry into host cells 0.6804826698608528 1.6796135739487374 0.0930325249420702 1.0 0.4284560038233091 8 O14964,Q92783 2 +Peptide ligand binding receptors 0.7343896424733571 1.677865139083123 0.0933734294046424 1.0 0.4284560038233091 6 P04083,P07602,P42892 3 +Class a 1 rhodopsin like receptors 0.7343896424733571 1.677865139083123 0.0933734294046424 1.0 0.4284560038233091 6 P04083,P07602,P42892 3 +Regulation of ifng signaling 0.902819919794566 1.6718535437620805 0.0945532054360076 1.0 0.4290806213663314 4 Q06124 1 +Phosphorylation of the apc c 0.6029475610067107 1.670803402664179 0.0947605162346927 1.0 0.4290806213663314 12 Q9UJX4,Q96DE5,Q9UJX6,Q13042,Q9UJX3,Q9H1A4,Q9UJX2 7 +Gene and protein expression by jak stat signaling after interleukin 12 stimulation 0.4712620303070703 1.6662754101432893 0.0956585720883296 1.0 0.429891147058328 25 P11233,P52597,P14174,P78417,O14979,Q13126,Q53EL6,P22626 8 +Visual phototransduction 0.7314984271455801 1.6652844744359152 0.0958560145024232 1.0 0.429891147058328 6 P49356,P30419,P29375 3 +Release of apoptotic factors from the mitochondria 0.9291814946619256 1.6651666506711278 0.09587951239056 1.0 0.429891147058328 2 O60443 1 +Mucopolysaccharidoses 0.8979781678102209 1.653508377804568 0.0982274424851983 1.0 0.430830707348381 4 P54802,P08236 2 +Diseases of carbohydrate metabolism 0.6552550847512313 1.6464362611436691 0.099673972695919 1.0 0.4338724478810552 9 P16278,P10253,P54802,P08236 4 +Bmal1 clock npas2 activates circadian gene expression 0.9238434163701124 1.6432630459826076 0.1003285205975266 1.0 0.434229432996235 2 P43490 1 +Response to elevated platelet cytosolic ca2 0.4641847211403558 1.635961652485024 0.1018476133597456 1.0 0.4380405189014767 28 O43852,Q8NBX0,Q9NTK5,P07602,Q06481,Q9NUQ9 6 +Innate immune system 0.3812180347978753 1.623905563808245 0.1043959649468244 1.0 0.44158042161198 258 O75874,P68371,P14174,Q9BTY2,P42785,P49721,P08236,Q9UQB8,P36543,O00264,P30519,P07858,P04439,P16278,P09960,O00584,P25788,Q8NF37,Q9Y487,P01889,Q93050,P28072,P06280,O15260,P10253,O95721,Q13685,P49720,P30154,P10321,P10619,P28074,Q99436,P45985,Q8IV08,P11717,O43865,Q92820,P09601,Q15750,O60443,Q06124,O75832,P07602,P20618,Q02750,P28070,P19474,P07437,P60900,Q9H7Z7,P17900 52 +Cell surface interactions at the vascular wall 0.5661554693693516 1.6229421302185103 0.1046017762564821 1.0 0.44158042161198 14 Q01650,P14174,P35613,Q9Y624,P53985,Q06124,Q92896 7 +Transport of inorganic cations anions and amino acids oligopeptides 0.6284202921501518 1.618409068597253 0.1055744689375914 1.0 0.4438094273518739 10 Q70HW3,Q9UBX3 2 +Endosomal vacuolar pathway 0.8871082621082592 1.6122517880371765 0.1069071599367297 1.0 0.4460022116880551 4 Q9UIQ6,P01889,P04439 3 +Collagen formation 0.602287167611513 1.596037404877927 0.110480442417955 1.0 0.4551926936859891 11 Q32P28,P13674,P07858 3 +Interleukin 3 interleukin 5 and gm csf signaling 0.7756694881318575 1.581543378210779 0.1137538487866263 1.0 0.4631813607077838 5 P46109,Q06124 2 +Gamma carboxylation hypusine formation and arylsulfatase activation 0.6598988414773657 1.581473708957083 0.1137697657132092 1.0 0.4631813607077838 8 O60725,Q9HA64,P38435,Q9BU89 4 +Ion channel transport 0.4576420224157768 1.5730898632620798 0.1156980117703068 1.0 0.4696380832806537 27 Q9HD20,Q9Y487,Q93050,Q9C0H2,P36543 5 +Metalloprotease dubs 0.8744629160844997 1.5641415768994953 0.1177843237989124 1.0 0.4737912825100466 4 Q92783 1 +Oncogenic mapk signaling 0.4687460226150669 1.5589686640454128 0.1190037970432997 1.0 0.4737912825100466 24 P30086,Q96PU8,Q02750,Q6RW13,P51114 5 +Synthesis of pa 0.652942900884403 1.5481351957023497 0.1215897498309435 1.0 0.4797167989128118 8 Q9NPH0,Q8N2A8,Q8NF37 3 +Ctla4 inhibitory signaling 0.7659200613380925 1.5416083771639 0.1231687886316077 1.0 0.4814460911754012 5 P30154,Q06124,P31751 3 +Heme degradation 0.765163083364781 1.5385035743289708 0.1239255352560217 1.0 0.4816595874539996 5 P30519 1 +Mitotic metaphase and anaphase 0.3712149067353802 1.5326854177838527 0.1253533838067861 1.0 0.4858328886522899 135 P55735,P68371,Q92674,O60216,O00231,P49721,Q8WYP5,Q99661,Q9BUF5,Q9H1A4,Q9UJX2,Q9HBM1,P57740,P50402,O60566,P25788,Q92973,P28072,Q13042,Q9UN37,Q9Y266,P49720,P30154,Q8NI77,Q9BW27,P61289,P28074,Q99436,Q96DE5,Q9UJX3,P42166,O43633,Q7L7X3,Q14739,O75832,Q9UJX4,P20618,Q9BTX1,Q8IXJ6,Q9UJX6,Q86XL3,Q8NFH4,P30153,P28070,Q8NBT2,Q9UL46,Q15691,Q9BVA1,P60900,Q12769 50 +Signalling to erks 0.6661075003355246 1.5309818360482117 0.1257738818798275 1.0 0.4860894815186573 7 P62993,P46109,Q02750,P11233 4 +Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.5292964458731155 1.5152853670768434 0.1297001523830934 1.0 0.4984554875899276 17 O76024,O43852,Q02818,Q07065,Q15293,Q9BTY2,Q06481,O43493,Q8NBJ4,P14625 10 +Tgf beta receptor signaling in emt epithelial to mesenchymal transition 0.8907473309608535 1.5072085573685745 0.1317572074958708 1.0 0.5028046380031189 2 Q9Y624 1 +Interleukin 12 signaling 0.4491971038193097 1.5048086572237298 0.1323732773755859 1.0 0.5030917910230024 27 P11233,P52597,P14174,P78417,O14979,Q13126,Q53EL6,P22626 8 +Antiviral mechanism by ifn stimulated genes 0.4151139675121569 1.4983499586265732 0.1340423505069423 1.0 0.5066283881419419 47 P55735,O00505,Q9BW27,Q9BTX1,Q99567,O00629,P52294,Q8NFH4,P57740,Q12769 10 +Slc mediated transmembrane transport 0.4900592404112118 1.4860858675218462 0.1372564099275526 1.0 0.5159336833441156 21 Q01650,Q8NEW0,Q8TB61,Q70HW3,P35613,P53985,Q9UBX3 7 +Hs gag degradation 0.9437522249910996 1.467884901752769 0.1421354900315439 1.0 0.5284820930170142 3 P54802,P08236 2 +Diseases of glycosylation 0.5283118327219007 1.465959636449853 0.1426592834727231 1.0 0.5287860851225392 16 P10619,P06865,O43505 3 +Jnk c jun kinases phosphorylation and activation mediated by activated human tak1 0.8797153024911039 1.461803733630811 0.1437950006954411 1.0 0.5289188765526682 2 P45985 1 +Phase i functionalization of compounds 0.5365570480991623 1.4467210036501128 0.1479750794022367 1.0 0.5413914905063169 14 P07099,Q16850 2 +Platelet sensitization by ldl 0.7382452085778568 1.4277534949143105 0.153362822703339 1.0 0.5525500993814724 5 P30154,P30153,Q06124 3 +Signaling by gpcr 0.4279491940213777 1.4205244450776868 0.1554550571146125 1.0 0.5525500993814724 34 P07602,P31751,P62136,O43865,P30153,P04083,P10644,P42892,Q9BYT8,P30154 10 +Mitochondrial calcium ion transport 0.5318478599196957 1.4185066249127236 0.1560429058863937 1.0 0.5532063743569305 14 P21796 1 +Sialic acid metabolism 0.8353142848541184 1.4145674701596858 0.1571953521458171 1.0 0.5534772986633945 4 P10619 1 +Metabolism of steroid hormones 0.6410286565451414 1.414110186085124 0.1573295528270581 1.0 0.5534772986633945 7 P30536 1 +Metabolism of porphyrins 0.5871467536664944 1.4039214453740447 0.160342242875763 1.0 0.5584013440763866 10 P30519 1 +Metabolism of lipids 0.369352617112634 1.4019676713890394 0.1609249007878812 1.0 0.5584013440763866 156 P30536,Q99829,P62136,Q15392,Q14914,P42126,P48449,O15254,Q96N66,P06865,Q15800,Q9BY49,Q96G23,P09960,P16278,Q8N2A8,Q8NF37,Q9BZF1,P06280,Q9NPH0,P51648,O95772,Q709F0,Q9BWD1,P37268,Q9UMR5,P10619,P50897,Q16850,Q8IV08,Q15067,O15270,O43772,O00116,Q8NCC3,P04062,Q86X55,P35790,Q14739,P07602,Q9Y217,Q15165,Q16836,Q06136,Q99943,P42356,P23786,Q9H7Z7,P17900 49 +Signaling by type 1 insulin like growth factor 1 receptor igf1r 0.6707909651248145 1.3984258350330745 0.1619852295498556 1.0 0.5584013440763866 6 Q06124,P31751 2 +Signaling by receptor tyrosine kinases 0.3478882908559018 1.3924430555222795 0.1637882741411573 1.0 0.5617937803041698 105 P52597,Q9UQB8,P36543,P62993,Q16543,Q16539,P31943,P11233,Q9Y487,Q93050,Q13685,P31483,P46109,P21283,P30154,Q92783,O43865,Q92542,O15514,Q96ST3,Q06124,P35269,Q92769,P31751,O14964,P40818,P30153,Q02750,P04792,Q15904,Q01085,P61421,P42345 33 +Heparan sulfate heparin hs gag metabolism 0.7291575401310568 1.3902322533464528 0.1644583623158553 1.0 0.5626854690707069 5 P16278,P54802,P08236 3 +Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.582291717409175 1.378497202136974 0.1680498310944691 1.0 0.5692490416813347 10 O43765,P50402,P46379,P09601 4 +Antigen processing ubiquitination proteasome degradation 0.3552607535006801 1.3709053251006442 0.1704044711351777 1.0 0.5738839620482298 84 Q15369,Q9Y3I1,P55786,O00231,P49721,Q9UIQ6,Q9UJX2,Q9UBS8,P25788,P28072,Q92990,Q13042,P49720,P52888,P28074,Q99436,Q9UJX3,Q9UJX4,O75832,P20618,Q9UJX6,P28070,P19474,Q9UL46,P60900 25 +Immunoregulatory interactions between a lymphoid and a non lymphoid cell 0.7242840003965455 1.3700882006753303 0.1706593706382491 1.0 0.5738839620482298 5 P10321,P01889,P04439 3 +Ksrp khsrp binds and destabilizes mrna 0.5329060295917905 1.347412080257936 0.177847552083016 1.0 0.5951386377021903 13 Q92945,Q16539,Q5RKV6,Q96B26 4 +Signaling by egfr 0.5445422033326258 1.3442448006921042 0.1788692388240436 1.0 0.5964014032459863 12 Q06124,Q92783,Q13685 3 +Mrna decay by 3 to 5 exoribonuclease 0.5120881089651984 1.3292134067967836 0.1837775731677862 1.0 0.6061125730437563 15 Q96C86,Q6PGP7,Q969T7,Q96B26 4 +Sphingolipid de novo biosynthesis 0.5898556346055215 1.3197786005996792 0.1869089483106447 1.0 0.6120900144146021 9 P51648,Q96G23,O15270,Q06136 4 +Diseases of mitotic cell cycle 0.5395852258566725 1.3162427983067382 0.1880925631275731 1.0 0.6120900144146021 12 Q9UJX4,P11802,Q96DE5,Q9UJX6,Q13042,Q9UJX3,Q9H1A4,Q9UJX2 8 +The phototransduction cascade 0.8961064982969905 1.2930747077551334 0.1959852217852042 1.0 0.6238787106480285 3 P49356 1 +Noncanonical activation of notch3 0.8377224199288323 1.2891454129038673 0.1973475381564831 1.0 0.6253136774842836 2 P67809 1 +Activation of ampk downstream of nmdars 0.7007320160674546 1.2725761355020615 0.2031684913971585 1.0 0.6383022413556415 5 P68371,Q9BVA1,Q9BUF5 3 +Pregnenolone biosynthesis 0.7002889807278989 1.2707399738644392 0.2038211696166691 1.0 0.6384535267444523 5 P30536 1 +Nrif signals cell death from the nucleus 0.831316725978649 1.262879984885632 0.2066323139781936 1.0 0.6410463377894949 2 Q92542 1 +Circadian clock 0.5923295561459199 1.2546516031199242 0.2096052618299491 1.0 0.6476991424114643 8 P43490,Q9BWF3,Q86X55 3 +Regulation of tp53 activity through acetylation 0.5583348345009373 1.2526038146775085 0.2103499259060943 1.0 0.6485395468385651 10 O95983,P31751 2 +Apoptotic factor mediated response 0.791791510137575 1.2476907274044915 0.212144338334725 1.0 0.6511454858953976 4 O60443 1 +Insulin receptor signalling cascade 0.694227685483063 1.245615047809882 0.2129057551514301 1.0 0.6513386739817592 5 Q06124,P31751 2 +Toll like receptor cascades 0.4281028106644706 1.2438713741752965 0.2135469063684729 1.0 0.6513386739817592 24 P45985,Q15750,O60443,P07858,Q06124,P30154 6 +Flt3 signaling 0.790735547778683 1.2436416248744495 0.2136314892797315 1.0 0.6513386739817592 4 Q06124,P31751 2 +Downregulation of erbb2 erbb3 signaling 0.8259786476868414 1.2410167457236851 0.2145995628020396 1.0 0.6516668721724113 2 P31751 1 +Regulation of tp53 expression and degradation 0.5730787092476082 1.235039223014879 0.2168159068536848 1.0 0.6516668721724113 9 P30154,P30153,P31751 3 +Neddylation 0.3640410679277963 1.2350369148701594 0.2168167658361086 1.0 0.6516668721724113 69 Q15369,Q9Y3I1,O00231,P49721,Q96GG9,Q13564,P25788,P28072,Q9BT78,P49720,P61289,P28074,Q99436,O75832,P20618,P28070,Q9UL46,Q9NV06,P60900 19 +Hemostasis 0.3372646155510284 1.2275036450028798 0.2196333526699627 1.0 0.6516668721724113 106 Q9NTK5,P68371,P14174,P42785,P10644,P07737,P62993,P53985,Q01650,Q13685,P30154,O43852,Q8NI77,Q96ST3,Q9NUQ9,Q92896,Q06124,P07602,Q9Y624,Q92769,P30153,Q06481,P35613,Q08380,Q9BVA1,Q8NBX0 26 +Metabolism of steroids 0.4000901292554843 1.2227090311513726 0.2214396146961086 1.0 0.6516668721724113 39 P30536,Q16850,Q15392,P48449,Q9BWD1,Q86X55,Q15800,P04062 8 +Aberrant regulation of mitotic exit in cancer due to rb1 defects 0.5508435722834093 1.2131233253861295 0.2250826732656072 1.0 0.6516668721724113 10 Q9UJX4,Q96DE5,Q9UJX6,Q13042,Q9UJX3,Q9H1A4,Q9UJX2 7 +Constitutive signaling by akt1 e17k in cancer 0.8188612099644225 1.2119061452653137 0.225548309525277 1.0 0.6516668721724113 2 P31751 1 +Cd28 dependent pi3k akt signaling 0.8188612099644225 1.2119061452653137 0.225548309525277 1.0 0.6516668721724113 2 P31751 1 +Rhou gtpase cycle 0.4956271124399901 1.2003897691298433 0.229988000383261 1.0 0.6516668721724113 14 O14964,Q92783 2 +Synthesis of substrates in n glycan biosythesis 0.5073341812366855 1.1981528807867097 0.2308575052490638 1.0 0.6516668721724113 13 P16278,P10619 2 +Assembly of the orc complex at the origin of replication 0.5655965059275736 1.1971790966071552 0.2312367555651964 1.0 0.6516668721724113 9 O60684,P52294 2 +G1 s specific transcription 0.564628023378628 1.1922764156004804 0.2331528789402754 1.0 0.6516668721724113 9 Q9Y619,P00374 2 +P75 ntr receptor mediated signalling 0.5176542713586714 1.1920418875092875 0.2332448213407869 1.0 0.6516668721724113 12 Q92542,Q13501,Q9NQC3,Q92769 4 +Signaling by notch3 0.5934940443956184 1.1907238791946275 0.2337620003775584 1.0 0.6516668721724113 7 P67809,Q92542,Q9Y6A5 3 +Flt3 signaling in disease 0.7749275768425882 1.183061248590796 0.2367848743150991 1.0 0.6516668721724113 4 P62993,Q06124 2 +E2f mediated regulation of dna replication 0.5265457683471869 1.1821620193835376 0.2371414196799373 1.0 0.6516668721724113 11 Q9Y619,P30153,P30154 3 +Pi 3k cascade fgfr2 0.809608540925282 1.1741429256071363 0.2403377823026238 1.0 0.6516668721724113 2 Q06124 1 +Frs mediated fgfr2 signaling 0.809608540925282 1.1741429256071363 0.2403377823026238 1.0 0.6516668721724113 2 Q06124 1 +Frs mediated fgfr3 signaling 0.809608540925282 1.1741429256071363 0.2403377823026238 1.0 0.6516668721724113 2 Q06124 1 +Pi 3k cascade fgfr3 0.809608540925282 1.1741429256071363 0.2403377823026238 1.0 0.6516668721724113 2 Q06124 1 +Frs mediated fgfr4 signaling 0.809608540925282 1.1741429256071363 0.2403377823026238 1.0 0.6516668721724113 2 Q06124 1 +Pi 3k cascade fgfr4 0.809608540925282 1.1741429256071363 0.2403377823026238 1.0 0.6516668721724113 2 Q06124 1 +Stat5 activation 0.809608540925282 1.1741429256071363 0.2403377823026238 1.0 0.6516668721724113 2 Q06124 1 +Frs mediated fgfr1 signaling 0.809608540925282 1.1741429256071363 0.2403377823026238 1.0 0.6516668721724113 2 Q06124 1 +Tie2 signaling 0.809608540925282 1.1741429256071363 0.2403377823026238 1.0 0.6516668721724113 2 Q06124 1 +Stat5 activation downstream of flt3 itd mutants 0.809608540925282 1.1741429256071363 0.2403377823026238 1.0 0.6516668721724113 2 Q06124 1 +Pi 3k cascade fgfr1 0.809608540925282 1.1741429256071363 0.2403377823026238 1.0 0.6516668721724113 2 Q06124 1 +Activated ntrk2 signals through frs2 and frs3 0.809608540925282 1.1741429256071363 0.2403377823026238 1.0 0.6516668721724113 2 Q06124 1 +Signaling by flt3 itd and tkd mutants 0.809608540925282 1.1741429256071363 0.2403377823026238 1.0 0.6516668721724113 2 Q06124 1 +Regulation of signaling by cbl 0.8096085409252667 1.1741429256070743 0.2403377823026486 1.0 0.6516668721724113 2 P46109 1 +Erythropoietin activates ras 0.8096085409252667 1.1741429256070743 0.2403377823026486 1.0 0.6516668721724113 2 P46109 1 +Antigen activates b cell receptor bcr leading to generation of second messengers 0.8096085409252638 1.1741429256070632 0.2403377823026531 1.0 0.6516668721724113 2 O43865 1 +Signaling by vegf 0.4366768740540967 1.1669782249340532 0.2432191633027294 1.0 0.6555927152285752 22 Q16539,P31751,O43865,P04792,Q9UQB8,Q13685,P42345 7 +P38mapk events 0.8064056939501769 1.1610951365531614 0.2456032123466047 1.0 0.6581398580850519 2 P11233 1 +Activated tak1 mediates p38 mapk activation 0.8064056939501747 1.1610951365531526 0.2456032123466083 1.0 0.6581398580850519 2 Q15750 1 +Postmitotic nuclear pore complex npc reformation 0.4257013542967885 1.152564875969961 0.2490890269108812 1.0 0.6623064824064516 23 P55735,Q9BW27,Q9BTX1,Q92973,Q8NFH4,P57740 6 +Vitamin d calciferol metabolism 0.8039145907473468 1.1509562368819684 0.2497502400956774 1.0 0.6627801342577746 2 P04062 1 +Neutrophil degranulation 0.3547963722702597 1.149041708816695 0.2505387825982039 1.0 0.6635892079628105 163 O75874,P68371,P14174,Q9BTY2,P42785,P08236,O00264,P30519,P04439,P16278,P07858,P09960,O00584,Q8NF37,P01889,Q93050,P06280,O15260,P10253,O95721,P10321,P10619,Q99436,Q92820,P07602,P20618,P07437,Q9H7Z7,P17900 29 +Pyruvate metabolism and citric acid tca cycle 0.4038270830585533 1.1463092404825277 0.2516672208524348 1.0 0.6652936936600012 29 P48735,P53985,P21796 3 +Unfolded protein response upr 0.3925815949240153 1.143819201616756 0.2526986248842315 1.0 0.6667356025791648 38 O76024,Q5RKV6,O14773,Q96B26,Q9Y5M8,Q92945,Q9Y2L1,Q9UBS4,P43307,P61421 10 +Transcriptional regulation by ventx 0.4971517807438598 1.1385974120531492 0.2548711083392674 1.0 0.6698911123399902 13 Q9UJX4,Q96DE5,Q9UJX6,Q9HCE1,Q13042,Q9UJX3,Q9H1A4,Q9UJX2 8 +Signaling by wnt 0.3454207116904511 1.1358044053389624 0.2560384329584819 1.0 0.6716725239369736 79 O75832,P25788,P20618,P28074,Q99436,P31751,P40818,Q13363,P30153,P28072,P28070,P49721,Q9UL46,P07737,P60900,P49720,P30154 17 +Negative regulation of the pi3k akt network 0.5350179607871401 1.12962708052829 0.2586333950791348 1.0 0.6771851489476585 10 P31751,P30153,Q06124,P30154 4 +Signaling by notch2 0.7971530249110315 1.123480854740259 0.2612333272339557 1.0 0.6826897618380711 2 Q92542 1 +Synthesis of pg 0.8492046561145523 1.121668534078908 0.2620034001042137 1.0 0.6834005036938807 3 Q8IV08 1 +Transcriptional regulation by mecp2 0.493568237386817 1.1176357542406894 0.2637225918782655 1.0 0.6852791591988263 13 Q14739,P42858,Q92769,Q96ST3,Q9HCE1 5 +Dna replication initiation 0.6065214749055716 1.1123320965368195 0.2659953885127415 1.0 0.6891823253890348 6 Q07864,Q9NR33 2 +Irs mediated signalling 0.7550064073418485 1.1068837004262717 0.2683442138880272 1.0 0.6902503504829989 4 Q06124,P31751 2 +Hur elavl1 binds and stabilizes mrna 0.6602305340634138 1.10472402309093 0.2692791906804554 1.0 0.6905627095581026 5 Q01105 1 +Keratan sulfate degradation 0.7535424499968439 1.1012962892997331 0.2707677256459433 1.0 0.6918029029971844 4 P06865 1 +Cilium assembly 0.3695968391717371 1.0802753766137052 0.2800195712793163 1.0 0.7031768551902957 49 A6NIH7,O94927,Q92973,P68371,O43924,O75935,P07437,Q9BVA1,Q9BW83,O95684 10 +Sulfur amino acid metabolism 0.5411949704404111 1.0735980928548727 0.2830028527544295 1.0 0.7059634799619586 9 Q13126 1 +Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 0.4649810263601895 1.0665653930791426 0.2861681347396416 1.0 0.7107961285596417 16 P16278,P10619 2 +Mastl facilitates mitotic progression 0.6507763982365418 1.0656223280105082 0.2865944017243624 1.0 0.7107961285596417 5 P30154 1 +Carboxyterminal post translational modifications of tubulin 0.6488125572416101 1.057508120251538 0.2902797506249248 1.0 0.7107961285596417 5 Q9BVA1,Q14679 2 +Uptake and function of anthrax toxins 0.8289895209449161 1.0483635735754573 0.2944711295844175 1.0 0.7107961285596417 3 P45985 1 +Organelle biogenesis and maintenance 0.3386517520161929 1.0477030788894253 0.2947754285937254 1.0 0.7107961285596417 79 A6NIH7,Q9Y512,Q92973,P68371,Q13505,O43924,O75935,P07437,Q86X55,Q9BVA1,P48735,O75964,Q9BW83,O95684 14 +Atf4 activates genes in response to endoplasmic reticulum stress 0.4921501481948813 1.0473717593765155 0.2949281513964257 1.0 0.7107961285596417 12 Q92945,Q5RKV6,Q96B26 3 +Perk regulates gene expression 0.4701479354882125 1.0465184173767366 0.2953217462327424 1.0 0.7107961285596417 14 Q92945,Q5RKV6,Q96B26 3 +Class i mhc mediated antigen processing presentation 0.3232930729576389 1.037314092246676 0.2995895002810951 1.0 0.7155571132255828 104 Q15369,P55735,Q9Y3I1,P55786,O00231,P49721,Q6P179,Q9UIQ6,Q9UJX2,Q9UBS8,P04439,P25788,P01889,Q9NZ08,P28072,Q92990,Q13042,P49720,P10321,P52888,P28074,Q99436,Q9UJX3,Q9UJX4,O75832,P20618,Q9UJX6,P28070,P19474,Q9UL46,P60900 31 +Intrinsic pathway for apoptosis 0.4481984748031834 1.027867013429007 0.3040123881319743 1.0 0.722056557237033 18 Q9NR28,P30419,O60443 3 +Hyaluronan metabolism 0.7333427835999511 1.0244099987694404 0.3056416612220696 1.0 0.7230006193046198 4 P08236 1 +Hyaluronan uptake and degradation 0.7333427835999511 1.0244099987694404 0.3056416612220696 1.0 0.7230006193046198 4 P08236 1 +Inhibition of replication initiation of damaged dna by rb1 e2f1 0.6396423440438868 1.0196644605048706 0.3078876222483839 1.0 0.7232081631053274 5 P30154 1 +Signaling by fgfr2 0.4247087164385788 1.0176091130657612 0.3088637547968502 1.0 0.7232081631053274 21 P31943,P35269,P30876,P52597,P30153,O15514,P31483,P62993,Q01085,Q06124 10 +Signaling by fgfr 0.4247087164385788 1.0176091130657612 0.3088637547968502 1.0 0.7232081631053274 21 P31943,P35269,P30876,P52597,P30153,O15514,P31483,P62993,Q01085,Q06124 10 +Negative regulation of fgfr2 signaling 0.730264094137353 1.0127320143970535 0.3111881817778501 1.0 0.7232081631053274 4 P30153,Q06124 2 +Negative regulation of fgfr1 signaling 0.730264094137353 1.0127320143970535 0.3111881817778501 1.0 0.7232081631053274 4 P30153,Q06124 2 +Negative regulation of fgfr4 signaling 0.730264094137353 1.0127320143970535 0.3111881817778501 1.0 0.7232081631053274 4 P30153,Q06124 2 +Spry regulation of fgf signaling 0.730264094137353 1.0127320143970535 0.3111881817778501 1.0 0.7232081631053274 4 P30153,Q06124 2 +Negative regulation of fgfr3 signaling 0.730264094137353 1.0127320143970535 0.3111881817778501 1.0 0.7232081631053274 4 P30153,Q06124 2 +G alpha i signalling events 0.4318087548391049 1.0113123210032084 0.311866970842146 1.0 0.7232081631053274 20 P07602,P62136,O43865,P30153,P04083,P30154 6 +Transport of bile salts and organic acids metal ions and amine compounds 0.8170167319330917 1.0051990652322385 0.3148010052076089 1.0 0.7271161265064636 3 P35613,P53985 2 +Regulation of mecp2 expression and activity 0.5262970674763362 0.9982251350155348 0.3181702008379836 1.0 0.7308615795605238 9 Q96ST3,Q14739,P42858,Q92769 4 +Golgi associated vesicle biogenesis 0.3829531231100338 0.9963377482078816 0.3190860686273715 1.0 0.7308615795605238 32 Q9H3P7,Q14789,P02786,P11717,O14976,Q9Y5X3,Q99523,O75976,O43493,Q14671,Q92572 11 +Extracellular matrix organization 0.4049085166849251 0.9947736930066666 0.3198463436695475 1.0 0.7313819725243654 23 Q32P28,Q9Y624,O14936,P13674,P07858 5 +Striated muscle contraction 0.6313101767706919 0.9853576141474976 0.324448441824088 1.0 0.7358672499120184 5 P09493,P08670 2 +Ire1alpha activates chaperones 0.4118354315388696 0.9836270811928232 0.3252989046977699 1.0 0.7358672499120184 22 O76024,O14773,Q9Y5M8,Q9UBS4,P43307,P61421 6 +Biological oxidations 0.3708396056899543 0.9791213285600784 0.3275200342956228 1.0 0.7380758534058455 42 P07099,Q16850,P78417,P21266,P21964,Q5VT66,Q9NUJ1,O43169 8 +Slc transporter disorders 0.3781326679735063 0.9789285137820456 0.3276153022770844 1.0 0.7380758534058455 34 P55735,P53985,Q9BTX1,Q9BW27,Q8NFH4,P35613,P57740,Q12769 8 +Post translational modification synthesis of gpi anchored proteins 0.5753295834173243 0.973588615658862 0.330260841140789 1.0 0.7422841917435967 6 O60762,Q96S52,O43292 3 +Met activates ptpn11 0.8078134694958339 0.9721738444702316 0.3309640702858476 1.0 0.7422841917435967 3 Q06124 1 +Methylation 0.5463456908875017 0.968618385208114 0.3327356268047334 1.0 0.7422841917435967 7 P78417 1 +Signalling to ras 0.8066927732289091 0.9681624172451312 0.3329632612911128 1.0 0.7422841917435967 3 P62993,P11233 2 +Pi3k akt signaling in cancer 0.546117562921612 0.967547408584237 0.3332704534359005 1.0 0.7422841917435967 7 Q06124,P42345,P31751 3 +Urea cycle 0.756583629893255 0.960415219526456 0.3368462812957506 1.0 0.7467748986739844 2 Q9Y619 1 +Signaling by notch1 pest domain mutants in cancer 0.5414502789425598 0.9456514295961538 0.3443264033699698 1.0 0.7476932090751651 7 Q92542,Q06330,Q92769 3 +Basigin interactions 0.5413640768533559 0.9452473102738044 0.3445326312101271 1.0 0.7476932090751651 7 Q01650,P53985 2 +Notch3 activation and transmission of signal to the nucleus 0.7999288002847992 0.9440014524153376 0.3451689060728284 1.0 0.7476932090751651 3 P67809,Q92542 2 +Aurka activation by tpx2 0.3974228270667317 0.9381292965686752 0.348177967750189 1.0 0.7476932090751651 23 Q15154,O94927,P68371,P63167,P30153,O75935,Q15691,P07437,Q13561,O95684 10 +Raf independent mapk1 3 activation 0.708692006172541 0.9312980508388254 0.3516994099575599 1.0 0.7492726559965406 4 Q06124 1 +Synthesis of leukotrienes lt and eoxins ex 0.7956933176682772 0.9289181999405492 0.3529314802154588 1.0 0.7493896014171623 3 Q14914 1 +Cooperation of prefoldin and tric cct in actin and tubulin folding 0.4425780306798524 0.925353430178174 0.3547820945047122 1.0 0.7493896014171623 16 Q99471,P68371,O15212,Q9BVA1,P61758,Q9NQP4 6 +Regulation of localization of foxo transcription factors 0.5643224997092195 0.9248738764016003 0.3550315167063815 1.0 0.7493896014171623 6 Q9Y3B8,P31751 2 +Interactions of vpr with host cellular proteins 0.3713806315142079 0.9191472625672344 0.3580185512373766 1.0 0.7524873301799391 34 P55735,Q9BW27,Q9BTX1,P52294,Q8NFH4,P57740,Q12769 7 +Intraflagellar transport 0.4950103276310199 0.918906499529697 0.3581444800346212 1.0 0.7524873301799391 10 P68371,Q9BVA1,Q9BW83 3 +Mitotic spindle checkpoint 0.3426817772212631 0.9143476418538076 0.360534204321346 1.0 0.7541902577300094 54 P55735,Q92674,Q8WYP5,Q99661,P57740,Q9H1A4,Q9HBM1,Q9UJX2,O60566,Q13042,Q9Y266,P30154,Q8NI77,Q9BW27,Q96DE5,Q9UJX3,Q7L7X3,Q9UJX4,Q9UJX6,P30153,Q8NFH4,Q8NBT2,Q15691,Q12769 24 +Ptk6 regulates proteins involved in rna processing 0.7914564995152219 0.913867771772331 0.3607863299777167 1.0 0.7541902577300094 3 Q07666 1 +Heme signaling 0.7030589076376212 0.9101660708541116 0.3627349346047945 1.0 0.7562909745830211 4 P09601 1 +Uptake and actions of bacterial toxins 0.5208103549657237 0.9060409697664246 0.3649141677503502 1.0 0.7585791487173947 8 P45985,Q7L0J3 2 +Met receptor recycling 0.700968500258165 0.902340237100184 0.3668761573054471 1.0 0.7615039150122139 4 P62993,P46109 2 +Sumoylation of ubiquitinylation proteins 0.3743080275364686 0.8923202852989088 0.3722212843818238 1.0 0.7655539904809422 27 P55735,Q9BW27,Q9BTX1,Q8NFH4,P57740,Q12769 6 +Regulation of glucokinase by glucokinase regulatory protein 0.3743080275364686 0.8923202852989088 0.3722212843818238 1.0 0.7655539904809422 27 P55735,Q9BW27,Q9BTX1,Q8NFH4,P57740,Q12769 6 +Sumoylation of sumoylation proteins 0.3743080275364686 0.8923202852989088 0.3722212843818238 1.0 0.7655539904809422 27 P55735,Q9BW27,Q9BTX1,Q8NFH4,P57740,Q12769 6 +Nod1 2 signaling pathway 0.6982192070194989 0.8920616776631122 0.3723598741507019 1.0 0.7655539904809422 4 Q15750,Q13685 2 +Activation of bad and translocation to mitochondria 0.517778505792446 0.8913651939719324 0.3727332839950943 1.0 0.7655539904809422 8 Q9Y3B8,P31751 2 +Sensory perception 0.3983683949718365 0.884693546193546 0.3763219374389788 1.0 0.7694918240120776 22 P49356,O14936,P30419,P29375 4 +Metabolism of folate and pterines 0.5283599652425759 0.8844250501186945 0.3764668053495643 1.0 0.7694918240120776 7 Q9H2D1 1 +Mapk3 erk1 activation 0.782612816070603 0.8825818496517823 0.3774622386967277 1.0 0.7695069710132397 3 Q06124 1 +Cargo trafficking to the periciliary membrane 0.426025922364506 0.8811180319617773 0.3782539383755812 1.0 0.7699377423376976 18 A6NIH7 1 +Gab1 signalosome 0.781913864324298 0.8801170548588708 0.3787959009314474 1.0 0.7699377423376976 3 Q06124 1 +Insulin processing 0.5531620823963298 0.8756913976969796 0.3811978231077035 1.0 0.7736736883191854 6 O00471,Q8NEW0 2 +Metabolism of cofactors 0.6911969250713297 0.8658838925731389 0.3865538370911836 1.0 0.780919341091408 4 O75874 1 +Protein protein interactions at synapses 0.4500152293851442 0.8639529188797029 0.3876137545796274 1.0 0.780919341091408 13 O95197,O14936 2 +Binding and uptake of ligands by scavenger receptors 0.5117647694463028 0.8623126343123396 0.3885155020785535 1.0 0.7812222370483938 8 Q07954,Q8WTV0 2 +Rho gtpases activate formins 0.335426300671929 0.8616086550150235 0.3889029066356071 1.0 0.7812222370483938 55 P55735,P68371,Q92674,Q8WYP5,P07737,Q99661,Q9BUF5,P57740,Q9HBM1,O60566,Q9Y266,P30154,Q8NI77,Q9BW27,Q7L7X3,P30153,Q8NFH4,P35080,Q8NBT2,Q15691,Q9BVA1,Q12769 22 +Synaptic adhesion like molecules 0.6003763219819744 0.8589398717080263 0.3903736902715209 1.0 0.7830302676206531 5 O95197,Q14254,P10586 3 +Cell death signalling via nrage nrif and nade 0.5088377243348067 0.8482023200808282 0.3963253053889048 1.0 0.7903463938860137 8 Q9NY61,Q92542,Q13501 3 +Suppression of phagosomal maturation 0.5154308036335986 0.8243018986379289 0.4097680400709373 1.0 0.8047514132869144 7 P52294 1 +Interleukin 12 family signaling 0.3641731314539822 0.8200268171131724 0.4122008196351476 1.0 0.8047514132869144 30 P11233,P52597,P14174,P78417,O14979,Q13126,Q53EL6,P22626 8 +Gap junction assembly 0.7636169455322331 0.8160473225409592 0.4144730705317108 1.0 0.8047514132869144 3 Q9BVA1,P68371 2 +Transport of connexons to the plasma membrane 0.7636169455322331 0.8160473225409592 0.4144730705317108 1.0 0.8047514132869144 3 Q9BVA1,P68371 2 +Degradation of the extracellular matrix 0.5392198391629818 0.8146374208562744 0.4152798838244427 1.0 0.8047514132869144 6 Q92542,P07858 2 +Tp53 regulates transcription of genes involved in g2 cell cycle arrest 0.5115346464525344 0.8062689095762391 0.420087813085559 1.0 0.8106335858697425 7 Q99873,Q86X55 2 +Signaling by hippo 0.6747856142668346 0.805182166528768 0.4207145659335334 1.0 0.810702787164056 4 Q4VCS5,Q07157 2 +Collagen biosynthesis and modifying enzymes 0.4858888196360482 0.7954082777619675 0.4263760463362644 1.0 0.814746428375146 9 Q32P28,P13674 2 +Amino acids regulate mtorc1 0.4557150469791127 0.7936731297625971 0.4273857469330964 1.0 0.8155399788486901 11 P55735,P61421,P42345,P36543 4 +Recruitment of numa to mitotic centrosomes 0.3612444309808732 0.7863047699940328 0.4316889586412507 1.0 0.8176073325540147 27 Q9BVA1,Q15154,O94927,P68371,P30153,O75935,Q15691,Q9BSJ2,P07437,Q13561,Q9BUF5,O95684 12 +Pkmts methylate histone lysines 0.4689857982432057 0.7833011832562079 0.4334502685538228 1.0 0.8176073325540147 10 Q9BYW2,Q03164,O96028 3 +Downregulation of erbb2 signaling 0.5316329134514447 0.7816362344262084 0.434428385883292 1.0 0.8176073325540147 6 Q16543,P31751 2 +Beta oxidation of very long chain fatty acids 0.6675509809774562 0.7786632788023015 0.4361780928028831 1.0 0.8186986847065751 4 Q15067,O75521 2 +Fgfr2 alternative splicing 0.4180524928865222 0.7724461298271982 0.4398502412303966 1.0 0.8210537836300738 16 P31943,P35269,P30876,P52597,O15514,P31483,Q01085 7 +Signaling by wnt in cancer 0.5029039267374995 0.7664882854005866 0.4433858195866214 1.0 0.8228421353966636 7 P30153,P30154 2 +Met activates rap1 and rac1 0.5763705009865215 0.7623539461541117 0.445848784936095 1.0 0.8228421353966636 5 P46109 1 +Beta catenin phosphorylation cascade 0.5759385292976998 0.7606319627522286 0.4468769231452569 1.0 0.8228421353966636 5 P30154 1 +Signaling by ctnnb1 phospho site mutants 0.5759385292976998 0.7606319627522286 0.4468769231452569 1.0 0.8228421353966636 5 P30154 1 +Disassembly of the destruction complex and recruitment of axin to the membrane 0.5759385292976998 0.7606319627522286 0.4468769231452569 1.0 0.8228421353966636 5 P30154 1 +Diseases associated with glycosylation precursor biosynthesis 0.5008931217882451 0.757256026785525 0.448896490003392 1.0 0.8233769843377726 7 P10619 1 +Death receptor signalling 0.4150217424247546 0.7537490912482931 0.4509998981557246 1.0 0.8261306545656264 16 Q9NQC3,Q92769,Q9NY61,Q92542,Q15750,Q13501 6 +Vitamin b5 pantothenate metabolism 0.6578003038267405 0.7431863042772043 0.4573688939859024 1.0 0.8344549501976837 4 Q9NVE7,Q9NRN7 2 +Regulation of glycolysis by fructose 2 6 bisphosphate metabolism 0.6571662827258369 0.740890697141134 0.4587597165380424 1.0 0.8352267716164717 4 P30154 1 +Rho gtpases activate iqgaps 0.4738273104287293 0.7357332173014264 0.4618930703212036 1.0 0.8380086851693413 9 Q9BVA1 1 +Transcriptional activation of mitochondrial biogenesis 0.4447783570117298 0.7347686968315337 0.4624803743956271 1.0 0.8380086851693413 11 P48735 1 +Negative regulation of mapk pathway 0.4849003369270803 0.7337632270674161 0.4630930560731308 1.0 0.8380086851693413 8 P30086,Q02750,P30154 3 +Dna damage reversal 0.6549685723932543 0.7329445198487695 0.4635922682533018 1.0 0.8380086851693413 4 Q8N3C0,Q9C0B1 2 +Cyclin a b1 b2 associated events during g2 m transition 0.471287704251461 0.7232420561674974 0.4695311848599761 1.0 0.8398915066856418 9 P30154 1 +Sumoylation of rna binding proteins 0.3493452826431253 0.7160929707807705 0.47393394384448 1.0 0.8466632434305035 33 P55735,Q9BW27,Q9BTX1,Q8IXK0,Q8NFH4,P61978,P57740,Q12769 8 +Notch hlh transcription pathway 0.6497197400552057 0.7140382331664532 0.4752035380320043 1.0 0.847827378647477 4 Q92769 1 +Nephrin family interactions 0.4905476129958225 0.7099993038347232 0.4777045678864882 1.0 0.8511826845977426 7 O14936,O43707 2 +O linked glycosylation of mucins 0.642307755144548 0.6875215906157996 0.4917540999162857 1.0 0.863740685738323 4 Q86SF2,O43505 2 +O linked glycosylation 0.6423077551445477 0.6875215906157982 0.4917540999162866 1.0 0.863740685738323 4 Q86SF2,O43505 2 +Signal amplification 0.5090784271698007 0.6847179162508052 0.4935219411249996 1.0 0.864136585402988 6 Q13685 1 +Recruitment of mitotic centrosome proteins and complexes 0.3478311988172821 0.6817479278709433 0.4953983558197552 1.0 0.8658427314454831 25 Q15154,O94927,P68371,P30153,P21127,O75935,Q15691,Q9BSJ2,P07437,Q13561,O95684 11 +Interleukin 17 signaling 0.40838785744858 0.679370102539772 0.496903388448022 1.0 0.8673682556624507 14 P45985,P30153,Q02750,Q15750,P30154 5 +Nr1h2 and nr1h3 mediated signaling 0.5547832733276944 0.6771519921120767 0.4983095239843238 1.0 0.8687174928926203 5 Q8NB78,P49327 2 +Autophagy 0.3394746494392944 0.6678718730718687 0.50421538296948 1.0 0.8708901775615971 40 Q9BVA1,P21796,Q8N4H5,Q9NS69 4 +Signaling by flt3 fusion proteins 0.7196445985561777 0.6664929116719177 0.5050960928961732 1.0 0.8708901775615971 3 P62993 1 +M phase 0.3282380236963566 0.664892317613654 0.5061193697769752 1.0 0.8708901775615971 183 P55735,Q01105,Q99567,P68371,Q92674,O60216,O00231,P49721,Q8WYP5,Q99661,Q9Y6X3,Q9BUF5,Q9UJX2,Q9H1A4,Q9HBM1,O95684,P57740,Q15154,P50402,P25788,Q92973,P28072,O75935,Q13042,P49720,P30154,Q8NI77,Q9BW27,P61289,P28074,Q99436,Q96DE5,Q9UJX3,P42166,O43633,Q7L7X3,O94927,Q14739,O75832,Q9UJX4,P20618,Q9BTX1,Q8IXJ6,Q9UJX6,Q86XL3,Q8NFH4,P30153,P28070,Q8NBT2,Q9UL46,Q15691,P07437,Q9BVA1,P60900,Q12769 55 +Plasma lipoprotein assembly remodeling and clearance 0.410123174955378 0.6372270693920277 0.5239769478706271 1.0 0.8769167290213484 13 Q8WTV0 1 +Transport of the slbp dependant mature mrna 0.3418509340079068 0.6353866239058682 0.5251762898023924 1.0 0.8769167290213484 30 P55735,Q9BW27,Q9BTX1,Q8NFH4,P57740,Q12769 6 +Regulation of beta cell development 0.7079767766368776 0.6281197138861159 0.5299255196213384 1.0 0.8769167290213484 3 P31751 1 +Plasma lipoprotein clearance 0.4237889909951834 0.6234841213183401 0.5329664335959885 1.0 0.8769167290213484 11 Q8WTV0 1 +Anchoring of the basal body to the plasma membrane 0.3477484323759786 0.6228174629686991 0.5334044813257122 1.0 0.8769167290213484 24 P68371,O75935,O95684,P07437 4 +Constitutive signaling by overexpressed erbb2 0.7059451762193025 0.6215038953525265 0.5342681323098137 1.0 0.8769167290213484 3 P62993,Q16543 2 +Adaptive immune system 0.3219795590271262 0.6165198980196025 0.5375514433975175 1.0 0.8797345780354144 169 Q15369,P55735,P68371,Q9Y3I1,P55786,O00231,P49721,Q6P179,P62993,Q9UIQ6,Q9UJX2,P04439,P07858,P25788,P01889,Q9NZ08,P28072,Q92990,O75935,P62942,P49720,P30154,P10321,Q8NI77,P10619,P28074,Q99436,O43865,Q9UJX3,Q06124,Q9UJX4,O75832,P20618,P31751,Q5KU26,Q9UJX6,P30153,P28070,P19474,Q9UL46,Q9BVA1,P60900,P42345 43 +Darpp 32 events 0.4487799754300361 0.6139411555057669 0.5392542129211251 1.0 0.8797345780354144 9 P62136,P30153,P30154 3 +Activation of ppargc1a pgc 1alpha by phosphorylation 0.6640569395017816 0.609674050861676 0.5420777473082323 1.0 0.8808277781344791 2 Q16539 1 +Mhc class ii antigen presentation 0.3229605007277132 0.6045365427535888 0.545486981504772 1.0 0.8835987469002919 49 P55735,P10619,O75935,Q9BVA1,P07858 5 +Signaling by met 0.3860081729961733 0.5976844322015077 0.5500505149575652 1.0 0.8878462429667993 17 Q92783,O14964,P40818,P46109,Q06124 5 +Tp53 regulates transcription of cell death genes 0.6159966535928926 0.5953464257133771 0.5516119289408477 1.0 0.8893202896672656 4 Q92696,P49327 2 +Signaling by notch1 0.4546266821412459 0.5925488068307321 0.5534831481598421 1.0 0.8912897644076331 8 Q92542,Q06330,Q92769 3 +Mtor signalling 0.4173696636218805 0.5900343190189206 0.5551676413636009 1.0 0.8913802758427238 11 P62942,P23588,P42345,P31751 4 +Alpha oxidation of phytanate 0.6139462647480337 0.5883065453286974 0.5563265530490975 1.0 0.8913802758427238 4 Q9BY49 1 +Interleukin 4 and interleukin 13 signaling 0.4092630675033192 0.5873226384889247 0.5569870396525138 1.0 0.8913802758427238 12 P04083,Q07820,P09601 3 +Nuclear pore complex npc disassembly 0.3349262293822163 0.582664970928798 0.5601188586222956 1.0 0.8913802758427238 31 P55735,Q9BW27,Q9BTX1,Q8NFH4,P57740,Q12769 6 +Ptk6 regulates cell cycle 0.6562277580071155 0.5821204019415133 0.560485583770074 1.0 0.8913802758427238 2 P11802 1 +Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects 0.6562277580071155 0.5821204019415133 0.560485583770074 1.0 0.8913802758427238 2 P11802 1 +Attachment of gpi anchor to upar 0.6085648404127406 0.5699385685010682 0.5687193646518838 1.0 0.8978948882207283 4 Q96S52,O43292 2 +Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand 0.3337741305858863 0.568134885943783 0.5699433810698351 1.0 0.8978948882207283 29 P68371,Q9BVA1,O75935 3 +Extra nuclear estrogen signaling 0.4261736882470415 0.5665546113965838 0.5710168196701073 1.0 0.8978948882207283 10 Q99873,P31751 2 +Export of viral ribonucleoproteins from nucleus 0.3331242188301008 0.5629811495882409 0.5734477200750521 1.0 0.8978948882207283 29 P55735,Q9BW27,Q9BTX1,Q8NFH4,P57740,Q12769 6 +Dap12 interactions 0.5203621979680473 0.5458270005383645 0.5851848614135329 1.0 0.9079189563490596 5 P10321,P01889 2 +Deadenylation of mrna 0.4083450360337459 0.5435749565924294 0.5867339970863794 1.0 0.9079189563490596 11 Q9H074,P23588 2 +Nuclear envelope ne reassembly 0.3152497164041173 0.5432307622100054 0.586970928776688 1.0 0.9079189563490596 50 Q9BVA1,P55735,P50402,Q9BW27,Q14739,Q9BTX1,Q92973,P68371,P30153,Q8NFH4,Q86XL3,Q8WYP5,Q9BUF5,Q8IXJ6,P57740,Q12769,P42166,O43633 18 +Notch1 intracellular domain regulates transcription 0.4738582094230042 0.5382912778872848 0.5903759719716455 1.0 0.908511016175328 6 Q06330,Q92769 2 +Map3k8 tpl2 dependent mapk1 3 activation 0.5990055349099168 0.5377185252794896 0.590771387773837 1.0 0.908511016175328 4 Q02750,P45985 2 +Glycogen storage diseases 0.6792475303534556 0.5365753992640337 0.5915609408717422 1.0 0.908511016175328 3 P10253 1 +Abc transporters in lipid homeostasis 0.6427046263345311 0.5355835136775844 0.5922464253053847 1.0 0.908511016175328 2 P40855 1 +Pp2a mediated dephosphorylation of key metabolic factors 0.6784308480413228 0.5340407851663639 0.5933133166859286 1.0 0.908511016175328 3 P30154 1 +Mitotic prometaphase 0.2940666119078125 0.5311522647471131 0.5953132688743619 1.0 0.9105571960932268 83 P55735,P68371,Q92674,O60216,Q8WYP5,Q99661,Q9BUF5,P57740,Q9HBM1,O95684,Q15154,O60566,O75935,Q9Y266,P30154,Q8NI77,Q9BW27,P49454,Q9BSJ2,Q7L7X3,O94927,P30153,Q8NFH4,Q8NBT2,Q15691,P07437,Q9BVA1,Q12769 28 +Cd163 mediating an anti inflammatory response 0.6391459074733195 0.5235731805723758 0.6005754392996043 1.0 0.913462675349029 2 Q16539 1 +Signal regulatory protein family interactions 0.6712584331267798 0.5119559956124531 0.608681807181799 1.0 0.9192017934793892 3 Q06124 1 +Hcmv early events 0.3217558301463124 0.5086365329715864 0.6110070165452592 1.0 0.9192017934793892 40 P55735,Q9BW27,Q9BTX1,Q99567,P68371,Q8NFH4,P83916,Q9BVA1,P57740,Q12769 10 +Post translational protein modification 0.2808208163498218 0.5053827100024 0.6132900603271865 1.0 0.9192017934793892 353 Q92734,Q86SF2,Q5VTR2,Q99567,Q9Y3I1,Q13363,P21796,Q10472,O00231,P45880,P49721,O00743,Q14258,Q15022,Q14789,Q13564,Q02818,P46977,P38435,P28072,Q12888,O43505,Q5H9R7,O75935,P10619,P28074,O60725,P20618,Q8NB78,Q06481,P28070,P60900,P55735,Q96FW1,Q9BTY2,P04439,P16278,Q96IJ6,Q92696,Q14679,O43852,Q92783,Q99436,Q9NXR7,P61978,Q96K76,O14964,Q8NFH4,Q96PC5,Q9BVA1,Q15369,P68371,O43493,Q9UPU5,P57740,Q8TEY7,P25788,Q9BU89,Q8NBJ4,P49720,Q9HA64,Q15750,O75832,Q96RU2,P04066,O60216,Q96GG9,Q8N6H7,P04844,Q12907,Q9BW27,Q8IXK0,Q12955,O15027,Q96ST3,Q9BTX1,Q92769,P40818,Q9UL46,Q9NV06,Q12769 81 +Signaling by fgfr1 0.509018475262821 0.5041049934637927 0.6141875981198472 1.0 0.9192017934793892 5 P30153,Q06124 2 +Signaling by fgfr3 0.509018475262821 0.5041049934637927 0.6141875981198472 1.0 0.9192017934793892 5 P30153,Q06124 2 +Signaling by fgfr4 0.509018475262821 0.5041049934637927 0.6141875981198472 1.0 0.9192017934793892 5 P30153,Q06124 2 +Egfr downregulation 0.4348752959021802 0.5035274269847863 0.6145935021696252 1.0 0.9192017934793892 8 O14964,Q92783 2 +Met activates ras signaling 0.5872348494772675 0.4988171312263915 0.6179082177699475 1.0 0.920486573305379 4 P62993 1 +Syndecan interactions 0.5836745582813578 0.4872298985789756 0.6260954195612296 1.0 0.9236590490731258 4 P12814,O14936 2 +Non integrin membrane ecm interactions 0.5836745582813578 0.4872298985789756 0.6260954195612296 1.0 0.9236590490731258 4 P12814,O14936 2 +Cell cell communication 0.3350817221115374 0.4810106135092403 0.6305089554713272 1.0 0.9249260215466776 23 O14936,Q06124 2 +Activation of nmda receptors and postsynaptic events 0.358887322312455 0.4782394040290398 0.632479819789687 1.0 0.9249260215466776 19 P68371,Q14168,P10644,Q9BVA1,Q9BUF5,O14936 6 +Runx1 regulates genes involved in megakaryocyte differentiation and platelet function 0.4079269420346967 0.4781394474681848 0.632550957087644 1.0 0.9249260215466776 10 Q03164,Q99873,Q96ST3 3 +Complex i biogenesis 0.346485555981144 0.4730331835828265 0.6361895048433284 1.0 0.9273951443457368 21 P03886,O75306,Q9Y6M9,O43676 4 +Prolonged erk activation events 0.5758345506647583 0.4620254690385906 0.6440630562222076 1.0 0.9351188940950288 4 Q02750 1 +Toll like receptor tlr1 tlr2 cascade 0.3680728446954213 0.4619920892877451 0.6440869933817801 1.0 0.9351188940950288 15 P45985,P30153,Q02750,Q15750,P30154 5 +E2f enabled inhibition of pre replication complex formation 0.4541986412905385 0.4601582095261532 0.6454026649075311 1.0 0.9358575402968424 6 Q9UBD5,Q9Y619 2 +Neurexins and neuroligins 0.4154340942385943 0.4583682540179085 0.6466878952380197 1.0 0.9358575402968424 9 O14936 1 +Maturation of sars cov 2 nucleoprotein 0.647561409754364 0.4413893402653631 0.6589311580022272 1.0 0.9406022392478224 3 Q99873,P48729 2 +Hiv infection 0.2958065643868002 0.4399301798196404 0.65998767674352 1.0 0.9406022392478224 130 P04439,P55735,P30419,Q15369,P25788,P28074,P20618,Q99436,P52294,Q8NFH4,P28072,P57740,P28070,P49721,P60900,Q92804 16 +Tysnd1 cleaves peroxisomal proteins 0.5629472252274301 0.4215825347821977 0.6733297565288938 1.0 0.9436245413254774 4 Q15067 1 +Formation of tc ner pre incision complex 0.3192184699265604 0.4160668584438156 0.6773610803765528 1.0 0.946374136737913 24 Q16531,P30876,P19387,P18074,O15514,Q99627,Q92905,Q9BT78,Q9UNS2,Q93009,Q7L5N1 11 +Glycogen breakdown glycogenolysis 0.4220107326005975 0.4127566069906644 0.6797849466072019 1.0 0.9478302304319928 7 P10253 1 +Sumoylation of chromatin organization proteins 0.3108465014653176 0.4087480671451536 0.68272455506923 1.0 0.9480749894281212 35 P55735,Q15022,Q9BW27,Q9BTX1,Q92769,Q99567,Q8IXK0,Q8NFH4,P57740,Q12769 10 +Copi independent golgi to er retrograde traffic 0.3105694884467475 0.401688731670911 0.687913118472179 1.0 0.9529563857558244 25 P68371,Q9BVA1,O75935 3 +Processing of dna double strand break ends 0.3495713981011902 0.4000785231873374 0.6890986821972513 1.0 0.9529563857558244 18 O96028,Q9UQ84 2 +Formation of tubulin folding intermediates by cct tric 0.378814707230415 0.3973603469867853 0.6911017520605287 1.0 0.9529563857558244 11 Q9BVA1 1 +Resolution of sister chromatid cohesion 0.2928433664222834 0.3899792151765529 0.6965519164396028 1.0 0.9553931646384024 59 P55735,P68371,Q92674,O60216,Q8WYP5,Q99661,Q9BUF5,P57740,Q9HBM1,O60566,Q9Y266,P30154,Q8NI77,Q9BW27,Q7L7X3,P30153,Q8NFH4,Q8NBT2,Q15691,Q9BVA1,Q12769 21 +Role of phospholipids in phagocytosis 0.6292966884625777 0.3897825086582184 0.6966973788879072 1.0 0.9553931646384024 3 Q8IV08 1 +Opioid signalling 0.3523968816094096 0.3866171475483385 0.6990396613927241 1.0 0.9571680792722728 16 P62136,P30154,O43865,P30153 4 +Cdc6 association with the orc origin complex 0.5493534760196361 0.3803640632494683 0.7036751868755653 1.0 0.9615959725032625 4 Q9Y619,Q9UBD5 2 +Response of mtb to phagocytosis 0.3739275134631497 0.3742049473824803 0.7082518434772545 1.0 0.9648206569989832 11 P52294 1 +Infection with mycobacterium tuberculosis 0.3739275134631497 0.3742049473824803 0.7082518434772545 1.0 0.9648206569989832 11 P52294 1 +Rhobtb2 gtpase cycle 0.3359288263585108 0.3706847052268482 0.7108723834939532 1.0 0.9656495388937932 20 Q16543,P12814,P38159,Q99832,P62995,Q96DH6,P07900 7 +Fcgamma receptor fcgr dependent phagocytosis 0.3240022564524699 0.3657215143545991 0.7145728905409987 1.0 0.9668579939075448 22 Q9UQB8 1 +Signaling by erbb2 0.3941292850987568 0.3645983590542318 0.7154112399319625 1.0 0.9670386415632044 9 Q16543,P40818,P31751 3 +Glutathione conjugation 0.3714644823278548 0.3626654259567649 0.7168548298711956 1.0 0.9670843919206296 11 P78417 1 +Regulation of plk1 activity at g2 m transition 0.3055465851211585 0.3521115017417 0.7247546429345015 1.0 0.9729582877750842 29 P68371,O75935,O95684,P07437 4 +Foxo mediated transcription 0.3644585116384107 0.330346177208237 0.7411384050971968 1.0 0.9793077029209551 11 P31751,Q92769,Q96ST3 3 +Activation of the pre replicative complex 0.3337939605644162 0.3280092125724111 0.7429046970199529 1.0 0.9793077029209551 19 P24941,Q9UBD5,Q07864,Q13416,P15927,Q9Y619,P49643,Q9NR33 8 +Mitochondrial biogenesis 0.3023469992235147 0.3277955175812106 0.7430662766988423 1.0 0.9793077029209551 30 Q9NX63,Q9Y512,Q13505,Q86X55,P48735,O75964,Q00059 7 +Mtorc1 mediated signalling 0.3966465217271036 0.3135061318428299 0.7538961628029486 1.0 0.9869709306924096 7 P62942,P23588 2 +Foxo mediated transcription of oxidative stress metabolic and neuronal genes 0.5224570962070623 0.3036908797898855 0.7613634069206181 1.0 0.9878118452387878 4 Q96ST3 1 +Metabolism of fat soluble vitamins 0.5955399005158168 0.3017237020262475 0.7628626982617093 1.0 0.9878118452387878 3 P29375 1 +Nuclear import of rev protein 0.2984052903250817 0.2989191163549201 0.765001760853991 1.0 0.9878118452387878 31 P55735,Q9BW27,Q9BTX1,Q8NFH4,P57740,Q12769 6 +Erks are inactivated 0.4101313354452611 0.2983036566318958 0.7654714136822951 1.0 0.9878118452387878 6 P30154 1 +Peroxisomal lipid metabolism 0.3568721901745501 0.2962458564383854 0.7670423312569081 1.0 0.9881521863704018 11 Q9BY49,P51648,O15254 3 +Nuclear signaling by erbb4 0.5906506799354053 0.2898303996880154 0.7719459899735195 1.0 0.9898833940274052 3 Q92542 1 +Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex 0.3636688079942979 0.2796360241402836 0.7797567659721574 1.0 0.99208816726646 10 P31946,Q9Y3B8,P63104,P14635,P27348,P62258,P61981,Q04917,O96017 9 +Reduction of cytosolic ca levels 0.5855137497616033 0.2775835159000258 0.7813320874439909 1.0 0.99208816726646 3 P30626 1 +Platelet calcium homeostasis 0.5855137497616033 0.2775835159000258 0.7813320874439909 1.0 0.99208816726646 3 P30626 1 +Aggrephagy 0.3466597247572166 0.2773284128029125 0.78152794458178 1.0 0.99208816726646 12 P68371,P63167,P08670,O43237,Q9BVA1,Q9BUF5 6 +Raf activation 0.3787575871538711 0.2717514739560798 0.7858131195800553 1.0 0.99208816726646 8 Q02750,P30154 2 +Deactivation of the beta catenin transactivating complex 0.3848092969279575 0.2699940532854029 0.7871648285657196 1.0 0.99208816726646 7 P31751 1 +Tryptophan catabolism 0.5822240828011362 0.2698768488613637 0.7872549984683039 1.0 0.99208816726646 3 Q01650 1 +Myd88 independent tlr4 cascade 0.3259093999426793 0.2684332178119356 0.7883658733123764 1.0 0.99208816726646 18 P45985,P30153,Q02750,Q15750,Q06124,P30154 6 +G beta gamma signalling through cdc42 0.5519572953736572 0.2677417665882621 0.7888980980231106 1.0 0.99208816726646 2 P63218 1 +G2 m dna damage checkpoint 0.2925488497875316 0.2626298971330619 0.7928358541582501 1.0 0.9923472849628864 28 O96028,Q9UQ84 2 +Deadenylation dependent mrna decay 0.2929005155282699 0.2610359139758496 0.794064811754664 1.0 0.9923472849628864 33 Q9H074,Q5RKV6,Q969T7,Q96B26,P23588,Q6PGP7,Q96C86 7 +Wnt mediated activation of dvl 0.5462633451957223 0.2540469110061427 0.7994593168843875 1.0 0.9923472849628864 2 P19784 1 +Cargo recognition for clathrin mediated endocytosis 0.29152276723842 0.2496381059470603 0.8028672270725101 1.0 0.9932676605441696 31 P02786,Q92783,P11717,O14964,Q96D71,Q99627,Q92905,O43493,Q14108,Q9BT78,P62993,Q9UNS2,Q7L5N1 13 +Cyclin d associated events in g1 0.3717616220804477 0.2457701482156272 0.805860166661934 1.0 0.995175651359292 8 P30153,P63208,P30154 3 +Gap junction trafficking and regulation 0.3551333995843427 0.2447362465496341 0.8066606606242686 1.0 0.9952683690436118 10 Q9BVA1,P68371,Q07157 3 +Post chaperonin tubulin folding pathway 0.3701558221484545 0.2399162170729377 0.8103952085665402 1.0 0.9977038857719892 8 P68371,Q9BVA1,P36404 3 +Translocation of slc2a4 glut4 to the plasma membrane 0.2891298463418527 0.2341039127609851 0.8149043083857148 1.0 0.9982577777725006 30 Q9BVA1,P31751,P68371,O00471,Q9UIQ6 5 +Met promotes cell motility 0.3892425333193796 0.2297776043355671 0.8182645882802124 1.0 0.9990530794716772 6 P46109 1 +Rnd1 gtpase cycle 0.3392605717701351 0.221093308173223 0.8250197806424273 1.0 0.9990530794716772 11 O75976,P38159 2 +Signaling by erbb4 0.3849953142520654 0.2166049337844899 0.8285162404182742 1.0 1.0 6 P62993,Q92542 2 +Hdms demethylate histones 0.3674949743659085 0.2100848431581731 0.8336014549184139 1.0 1.0 7 Q8NB78 1 +Toll like receptor 9 tlr9 cascade 0.3160136168339969 0.2083675126947687 0.8349420207162859 1.0 1.0 17 P45985,P30153,Q02750,Q15750,P30154 5 +The citric acid tca cycle and respiratory electron transport 0.2699791626404177 0.2045046617772042 0.8379591494044119 1.0 1.0 80 P21912,O43676,O75964,P21796,O75306,P47985,P48735,P53985 8 +Trans golgi network vesicle budding 0.2849691424204796 0.2035711716913043 0.8386886230345101 1.0 1.0 40 Q9H3P7,Q14789,P11717,O14976,O14964,Q9Y5X3,Q99523,O75976,O43493,Q14671,Q92572,O43633 12 +Receptor mediated mitophagy 0.5464578141687446 0.1932701924903238 0.8467473691482872 1.0 1.0 3 Q96HS1,P19784 2 +Leishmania infection 0.2823057909797348 0.1910165935952976 0.8485125927150325 1.0 1.0 29 Q9UQB8 1 +Integrin cell surface interactions 0.474778222810581 0.1863611735795238 0.852161538006825 1.0 1.0 4 Q9Y624 1 +Glycogen metabolism 0.339796335150497 0.1854163360611409 0.8529024962497285 1.0 1.0 10 P10253,P35573 2 +Activation of bh3 only proteins 0.3249135363522115 0.1851177153575474 0.8531367069003191 1.0 1.0 12 P63167,Q13625,Q9Y3B8,P31751 4 +Mecp2 regulates neuronal receptors and channels 0.3559245024356461 0.1727726971321698 0.8628300988052529 1.0 1.0 7 Q96ST3 1 +Transport of mature mrnas derived from intronless transcripts 0.2798880741418313 0.169813355615491 0.86515692321972 1.0 1.0 36 P55735,Q9BW27,Q9BTX1,Q99567,Q8NFH4,Q92797,P57740,Q12769 8 +Interactions of rev with host cellular proteins 0.2792014893810879 0.1656498102490652 0.8684325458472091 1.0 1.0 34 P55735,Q9BW27,Q9BTX1,Q8NFH4,P57740,Q12769 6 +Phase ii conjugation of compounds 0.2765231780747272 0.1631310841457967 0.8704152259956648 1.0 1.0 27 P78417,Q9NUJ1,P21266 3 +Cd209 dc sign signaling 0.5014234875444739 0.1611295283612976 0.8719913838331701 1.0 1.0 2 P17612 1 +Sema4d mediated inhibition of cell attachment and migration 0.5007117437722308 0.1598730347828042 0.8729810903968944 1.0 1.0 2 Q9NWH9 1 +Nef and signal transduction 0.5007117437722307 0.1598730347828036 0.8729810903968949 1.0 1.0 2 Q13177 1 +Transport and synthesis of paps 0.5260853267924365 0.1557912140622196 0.8761975962275468 1.0 1.0 3 Q8TB61 1 +Rap1 signalling 0.5129939480242047 0.1341418816610133 0.8932903821225648 1.0 1.0 3 P17612,P31946 2 +Smooth muscle contraction 0.309894575564288 0.1277774326995761 0.8983251097440224 1.0 1.0 12 P60660,P04083 2 +Telomere c strand synthesis initiation 0.4412393162393149 0.120075429528942 0.9044233959417156 1.0 1.0 4 P49642,P49643,Q9NYB0 3 +Ephrin signaling 0.5008899964400155 0.1158277731046939 0.9077890389000838 1.0 1.0 3 Q13177,Q14155 2 +Initiation of nuclear envelope ne reformation 0.2942995615954627 0.1152232535186334 0.9082681677841162 1.0 1.0 18 Q14739,P50402,Q86XL3,P30153,Q8IXJ6 5 +Kinesins 0.295702327593332 0.1147222577287213 0.908665271290251 1.0 1.0 16 P68371,Q8NI77,Q99661,Q9BVA1 4 +Sumoylation of dna replication proteins 0.2705748198666042 0.1082859021095763 0.9137689053416284 1.0 1.0 33 P55735,Q9BW27,Q9BTX1,Q8NFH4,P57740,Q12769 6 +Tristetraprolin ttp zfp36 binds and destabilizes mrna 0.3032098263190976 0.1041014397392129 0.9170888483212392 1.0 1.0 12 Q96B26,Q92973 2 +Sumoylation of dna damage response and repair proteins 0.2712325905051225 0.1033824725132119 0.9176594225104288 1.0 1.0 41 P55735,Q9BW27,Q9BTX1,Q8IXK0,Q8NFH4,O60216,P57740,Q12769 8 +G alpha q signalling events 0.3298735776122001 0.0976349762826142 0.9222221501206558 1.0 1.0 7 P04083 1 +Biosynthesis of specialized proresolving mediators spms 0.4810498289083572 0.0893104068912939 0.9288352236191662 1.0 1.0 3 Q14914 1 +Rhobtb gtpase cycle 0.2654181422778954 0.0874680213640306 0.930299503239156 1.0 1.0 29 Q16543,Q5VTR2,P12814,P08670,P38159,Q8N684,Q99832,P62995,Q96DH6,Q9BT78,P07900 11 +G0 and early g1 0.3630210188813559 0.0861162935425403 0.9313739713670436 1.0 1.0 5 P12004,P11388,Q13547,P24941 4 +Rho gtpases activate nadph oxidases 0.3612397577484838 0.082815037077596 0.9339986123417549 1.0 1.0 5 Q16539,P05771,P63000,Q99570 4 +Tp53 regulates transcription of cell cycle genes 0.2956730256340084 0.0788469995121384 0.9371543201801298 1.0 1.0 12 Q99873,Q9Y3B8,Q86X55 3 +Tp53 regulates transcription of death receptors and ligands 0.4705275875702158 0.0769741955881413 0.9386440729857786 1.0 1.0 3 P49327 1 +Muscle contraction 0.2627211545390508 0.0709078210276806 0.943471118766308 1.0 1.0 24 O43865,P60660,P08670,P04083 4 +Amyloid fiber formation 0.3285931524112971 0.0697429109930811 0.9443982868804603 1.0 1.0 6 Q9Y287 1 +Dna damage recognition in gg ner 0.2781407119853652 0.0564174856343192 0.9550092276181186 1.0 1.0 14 Q99627,Q92905,Q9BT78,Q9UNS2,Q16531,Q7L5N1 6 +Polo like kinase mediated events 0.396011396011392 0.0532911988926042 0.9574998925050596 1.0 1.0 4 P14635,O95067,P49454 3 +Nonhomologous end joining nhej 0.2859404687364714 0.0485714150361266 0.9612608505645348 1.0 1.0 12 O96028 1 +Protein folding 0.2607171547121439 0.0484473097037512 0.9613597558547018 1.0 1.0 33 Q99471,P36404,P68371,O15212,P04062,Q9BVA1,P61758,Q9Y2T2,Q9NQP4 9 +Transcriptional regulation by e2f6 0.317599284859919 0.0476896522513762 0.961963581027946 1.0 1.0 6 Q15022,P31350 2 +Regulation of cytoskeletal remodeling and cell spreading by ipp complex components 0.3857651245551604 0.0393572045780779 0.9686055992530735 1.0 1.0 2 P12814 1 +Vegfr2 mediated vascular permeability 0.3002859303396475 0.038587925622877 0.969218929081032 1.0 1.0 9 P31751 1 +Activation of puma and translocation to mitochondria 0.3829181494661975 0.0380928155131892 0.969613679544334 1.0 1.0 2 Q13625 1 +Tp53 regulates transcription of genes involved in cytochrome c release 0.3829181494661975 0.0380928155131892 0.969613679544334 1.0 1.0 2 Q13625 1 +Tp53 regulates transcription of genes involved in g1 cell cycle arrest 0.3829181494661934 0.0380928155131873 0.9696136795443356 1.0 1.0 2 P24941 1 +Rhot1 gtpase cycle 0.3772241992882605 0.0357417971142833 0.97148824255097 1.0 1.0 2 Q8IXI2 1 +Nrage signals death through jnk 0.3286464197280836 0.0311099327982888 0.9751818682773176 1.0 1.0 5 Q9NY61 1 +Erk mapk targets 0.297146775618719 0.030856683866053 0.9753838347261794 1.0 1.0 9 P30153,P30154 2 +Mapk targets nuclear events mediated by map kinases 0.297146775618719 0.030856683866053 0.9753838347261794 1.0 1.0 9 P30153,P30154 2 +Hcmv infection 0.2577480276950589 0.0276111145718902 0.977972316899606 1.0 1.0 49 P55735,Q9BW27,Q9BTX1,Q99567,P68371,Q8NFH4,P61978,P83916,Q9BVA1,P57740,Q12769 11 +Regulation of tp53 activity through phosphorylation 0.2518859523896798 0.0261039098529651 0.9791744585148864 1.0 1.0 27 Q92804 1 +Fbxw7 mutants and notch1 in cancer 0.2943060498220737 0.0200659810401658 0.9839907378757068 1.0 1.0 2 P63208 1 +Synthesis of diphthamide eef2 0.2896797153025007 0.0198137017708684 0.9841919875970088 1.0 1.0 2 Q9H2P9 1 +Rho gtpases activate paks 0.2865810135617511 0.0197914672976401 0.9842097246618468 1.0 1.0 10 O14974,P60660,P60953,Q14247,P21333,P35580,P35579,Q13177,P63000 9 +Oncogene induced senescence 0.3611111111111129 0.0186819778477831 0.9850948053410082 1.0 1.0 4 Q9HCE1,P11802,P04637 3 +Viral messenger rna synthesis 0.2551713645553244 0.0146027547954062 0.9883491014788296 1.0 1.0 35 P55735,P35269,Q9BW27,Q9BTX1,Q99567,Q8NFH4,O15514,P57740,Q12769 9 +Displacement of dna glycosylase by apex1 0.3724120957863676 0.0109068070979149 0.9912977995426272 1.0 1.0 3 P13051 1 +Scavenging by class a receptors 0.366965287243743 0.009266777629128 0.9926062870217358 1.0 1.0 3 Q5KU26 1 +Diseases of mismatch repair mmr 0.3616945532217912 0.0078224083248476 0.9937586848204608 1.0 1.0 3 P43246,P52701 2 +Signaling by erbb2 in cancer 0.344500136831644 0.0067819152170005 0.9945888560360764 1.0 1.0 4 Q16543 1 +Signaling by erbb2 ecd mutants 0.344500136831644 0.0067819152170005 0.9945888560360764 1.0 1.0 4 Q16543 1 +Signaling by egfr in cancer 0.344500136831644 0.0067819152170005 0.9945888560360764 1.0 1.0 4 Q16543 1 +Constitutive signaling by egfrviii 0.344500136831644 0.0067819152170005 0.9945888560360764 1.0 1.0 4 Q16543 1 +Constitutive signaling by ligand responsive egfr cancer variants 0.344500136831644 0.0067819152170005 0.9945888560360764 1.0 1.0 4 Q16543 1 +Aquaporin mediated transport 0.3078987253801305 0.0065123855220706 0.9948039048667112 1.0 1.0 5 P10644 1 +Processing of intronless pre mrnas 0.2630856642164647 0.0059300216669605 0.9952685549970564 1.0 1.0 15 Q5KU26,Q92797,P51003,O94992 4 +Sumoylation of transcription factors 0.3481666073335753 0.0046974671931028 0.9962519772358523 1.0 1.0 3 Q12888,P04637 2 +Metabolism of carbohydrates 0.2419499140123223 0.0044410866574158 0.996456537170965 1.0 1.0 95 P55735,Q8TB61,P08236,P06865,P13807,P57740,P16278,Q7LGA3,O43505,P10253,Q9UBX3,P30154,Q9BW27,P54802,P46926,O43252,Q9BTX1,P30153,Q8NFH4,P35573,Q12769 21 +Oxidative stress induced senescence 0.2692416197244826 0.0029663136020704 0.9976332276452872 1.0 1.0 12 Q16539,Q15022,P45985,Q8IXK0,Q99496,Q9HCE1 6 +Sensing of dna double strand breaks 0.3339266642933472 0.0021913856872009 0.998251528592828 1.0 1.0 3 P52292,P49959 2 +Bile acid and bile salt metabolism 0.2886671418389111 0.0002129987706271 0.9998300515707316 1.0 1.0 6 Q9BZF3,P22059,P51659,Q96SU4,O14734 5 +Synthesis of bile acids and bile salts 0.2886671418389111 0.0002129987706271 0.9998300515707316 1.0 1.0 6 Q9BZF3,P22059,P51659,Q96SU4,O14734 5 diff --git a/msigdb_reactome/selections.json b/msigdb_reactome/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..cc641e2a68976bbc0b51e426f129f5702689b131 --- /dev/null +++ b/msigdb_reactome/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["2 ltr circle formation", "A tetrasaccharide linker sequence is required for gag synthesis", "Abacavir metabolism", "Abacavir transmembrane transport", "Abacavir transport and metabolism", "Abc family proteins mediated transport", "Abc transporter disorders", "Abc transporters in lipid homeostasis", "Aberrant regulation of mitotic exit in cancer due to rb1 defects", "Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects", "Abortive elongation of hiv 1 transcript in the absence of tat", "Acetylcholine regulates insulin secretion", "Activated notch1 transmits signal to the nucleus", "Activated ntrk2 signals through cdk5", "Activated ntrk2 signals through frs2 and frs3", "Activated ntrk2 signals through fyn", "Activated ntrk2 signals through pi3k", "Activated ntrk2 signals through ras", "Activated ntrk3 signals through ras", "Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3", "Activated tak1 mediates p38 mapk activation", "Activation of ampk downstream of nmdars", "Activation of anterior hox genes in hindbrain development during early embryogenesis", "Activation of atr in response to replication stress", "Activation of bad and translocation to mitochondria", "Activation of bh3 only proteins", "Activation of gene expression by srebf srebp", "Activation of irf3 irf7 mediated by tbk1 ikk epsilon", "Activation of kainate receptors upon glutamate binding", "Activation of nima kinases nek9 nek6 nek7", "Activation of nmda receptors and postsynaptic events", "Activation of noxa and translocation to mitochondria", "Activation of ppargc1a pgc 1alpha by phosphorylation", "Activation of puma and translocation to mitochondria", "Activation of rac1", "Activation of rac1 downstream of nmdars", "Activation of smo", "Activation of the ap 1 family of transcription factors", "Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s", "Activation of the pre replicative complex", "Acyl chain remodeling of cl", "Acyl chain remodelling of pc", "Acyl chain remodelling of pg", "Acyl chain remodelling of pi", "Acyl chain remodelling of ps", "Adaptive immune system", "Adenylate cyclase inhibitory pathway", "Adherens junctions interactions", "Adora2b mediated anti inflammatory cytokines production", "Adp signalling through p2y purinoceptor 1", "Adp signalling through p2y purinoceptor 12", "Adrenaline noradrenaline inhibits insulin secretion", "Advanced glycosylation endproduct receptor signaling", "Aflatoxin activation and detoxification", "Aggrephagy", "Akt phosphorylates targets in the cytosol", "Akt phosphorylates targets in the nucleus", "Alk mutants bind tkis", "Alpha defensins", "Alpha linolenic omega3 and linoleic omega6 acid metabolism", "Alpha oxidation of phytanate", "Alpha protein kinase 1 signaling pathway", "Amino acid transport across the plasma membrane", "Amino acids regulate mtorc1", "Amyloid fiber formation", "Anchoring of the basal body to the plasma membrane", "Androgen biosynthesis", "Anti inflammatory response favouring leishmania parasite infection", "Antigen activates b cell receptor bcr leading to generation of second messengers", "Antigen presentation folding assembly and peptide loading of class i mhc", "Antigen processing cross presentation", "Antigen processing ubiquitination proteasome degradation", "Antimicrobial peptides", "Antiviral mechanism by ifn stimulated genes", "Apc c cdc20 mediated degradation of cyclin b", "Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1", "Apc c mediated degradation of cell cycle proteins", "Apc cdc20 mediated degradation of nek2a", "Apex1 independent resolution of ap sites via the single nucleotide replacement pathway", "Apobec3g mediated resistance to hiv 1 infection", "Apoptosis", "Apoptosis induced dna fragmentation", "Apoptotic cleavage of cell adhesion proteins", "Apoptotic cleavage of cellular proteins", "Apoptotic execution phase", "Apoptotic factor mediated response", "Aquaporin mediated transport", "Arachidonate production from dag", "Arachidonic acid metabolism", "Arms mediated activation", "Aryl hydrocarbon receptor signalling", "Asparagine n linked glycosylation", "Aspartate and asparagine metabolism", "Assembly and cell surface presentation of nmda receptors", "Assembly of collagen fibrils and other multimeric structures", "Assembly of the hiv virion", "Assembly of the orc complex at the origin of replication", "Association of tric cct with target proteins during biosynthesis", "Asymmetric localization of pcp proteins", "Atf4 activates genes in response to endoplasmic reticulum stress", "Atf6 atf6 alpha activates chaperone genes", "Atf6 atf6 alpha activates chaperones", "Attachment and entry", "Attachment of gpi anchor to upar", "Attenuation phase", "Auf1 hnrnp d0 binds and destabilizes mrna", "Aurka activation by tpx2", "Autophagy", "B wich complex positively regulates rrna expression", "Base excision repair", "Base excision repair ap site formation", "Basigin interactions", "Bbsome mediated cargo targeting to cilium", "Beta catenin independent wnt signaling", "Beta catenin phosphorylation cascade", "Beta oxidation of butanoyl coa to acetyl coa", "Beta oxidation of decanoyl coa to octanoyl coa coa", "Beta oxidation of hexanoyl coa to butanoyl coa", "Beta oxidation of lauroyl coa to decanoyl coa coa", "Beta oxidation of octanoyl coa to hexanoyl coa", "Beta oxidation of pristanoyl coa", "Beta oxidation of very long chain fatty acids", "Bh3 only proteins associate with and inactivate anti apoptotic bcl 2 members", "Bile acid and bile salt metabolism", "Binding and uptake of ligands by scavenger receptors", "Binding of tcf lef ctnnb1 to target gene promoters", "Biological oxidations", "Biosynthesis of epa derived spms", "Biosynthesis of maresins", "Biosynthesis of specialized proresolving mediators spms", "Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein", "Biotin transport and metabolism", "Bmal1 clock npas2 activates circadian gene expression", "Branched chain amino acid catabolism", "Budding and maturation of hiv virion", "Butyrate response factor 1 brf1 binds and destabilizes mrna", "C type lectin receptors clrs", "Ca dependent events", "Ca2 pathway", "Calcineurin activates nfat", "Calnexin calreticulin cycle", "Camk iv mediated phosphorylation of creb", "Carboxyterminal post translational modifications of tubulin", "Cardiac conduction", "Cargo concentration in the er", "Cargo recognition for clathrin mediated endocytosis", "Cargo trafficking to the periciliary membrane", "Carnitine metabolism", "Caspase activation via death receptors in the presence of ligand", "Caspase activation via dependence receptors in the absence of ligand", "Caspase activation via extrinsic apoptotic signalling pathway", "Caspase mediated cleavage of cytoskeletal proteins", "Cation coupled chloride cotransporters", "Cd163 mediating an anti inflammatory response", "Cd209 dc sign signaling", "Cd28 co stimulation", "Cd28 dependent pi3k akt signaling", "Cd28 dependent vav1 pathway", "Cdc42 gtpase cycle", "Cdc6 association with the orc origin complex", "Cdt1 association with the cdc6 orc origin complex", "Cell cell communication", "Cell cell junction organization", "Cell cycle", "Cell cycle checkpoints", "Cell cycle mitotic", "Cell death signalling via nrage nrif and nade", "Cell extracellular matrix interactions", "Cell junction organization", "Cell surface interactions at the vascular wall", "Cellular hexose transport", "Cellular response to chemical stress", "Cellular response to heat stress", "Cellular response to hypoxia", "Cellular response to starvation", "Cellular responses to stimuli", "Cellular senescence", "Chaperone mediated autophagy", "Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex", "Chl1 interactions", "Cholesterol biosynthesis", "Choline catabolism", "Chondroitin sulfate dermatan sulfate metabolism", "Chrebp activates metabolic gene expression", "Chromatin modifying enzymes", "Chromosome maintenance", "Chylomicron assembly", "Cilium assembly", "Circadian clock", "Citric acid cycle tca cycle", "Class a 1 rhodopsin like receptors", "Class b 2 secretin family receptors", "Class i mhc mediated antigen processing presentation", "Class i peroxisomal membrane protein import", "Clathrin mediated endocytosis", "Clec7a dectin 1 induces nfat activation", "Clec7a dectin 1 signaling", "Cobalamin cbl vitamin b12 transport and metabolism", "Coenzyme a biosynthesis", "Cohesin loading onto chromatin", "Collagen biosynthesis and modifying enzymes", "Collagen degradation", "Collagen formation", "Competing endogenous rnas cernas regulate pten translation", "Complement cascade", "Complex i biogenesis", "Condensation of prometaphase chromosomes", "Condensation of prophase chromosomes", "Constitutive signaling by aberrant pi3k in cancer", "Constitutive signaling by akt1 e17k in cancer", "Constitutive signaling by egfrviii", "Constitutive signaling by ligand responsive egfr cancer variants", "Constitutive signaling by overexpressed erbb2", "Conversion from apc c cdc20 to apc c cdh1 in late anaphase", "Cooperation of pdcl phlp1 and tric cct in g protein beta folding", "Cooperation of prefoldin and tric cct in actin and tubulin folding", "Copi dependent golgi to er retrograde traffic", "Copi independent golgi to er retrograde traffic", "Copi mediated anterograde transport", "Copii mediated vesicle transport", "Costimulation by the cd28 family", "Creatine metabolism", "Creb phosphorylation", "Creb1 phosphorylation through nmda receptor mediated activation of ras signaling", "Creb1 phosphorylation through the activation of adenylate cyclase", "Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde", "Cristae formation", "Crmps in sema3a signaling", "Cross presentation of soluble exogenous antigens endosomes", "Cs ds degradation", "Ctla4 inhibitory signaling", "Cyclin a b1 b2 associated events during g2 m transition", "Cyclin a cdk2 associated events at s phase entry", "Cyclin d associated events in g1", "Cytochrome c mediated apoptotic response", "Cytochrome p450 arranged by substrate type", "Cytokine signaling in immune system", "Cytoprotection by hmox1", "Cytosolic iron sulfur cluster assembly", "Cytosolic sensors of pathogen associated dna", "Cytosolic sulfonation of small molecules", "Cytosolic trna aminoacylation", "Dag and ip3 signaling", "Dap12 interactions", "Dap12 signaling", "Darpp 32 events", "Dcc mediated attractive signaling", "Ddx58 ifih1 mediated induction of interferon alpha beta", "Deactivation of the beta catenin transactivating complex", "Deadenylation dependent mrna decay", "Deadenylation of mrna", "Death receptor signalling", "Dectin 1 mediated noncanonical nf kb signaling", "Defective cftr causes cystic fibrosis", "Defective factor ix causes hemophilia b", "Defective intrinsic pathway for apoptosis", "Defective ripk1 mediated regulated necrosis", "Defects in biotin btn metabolism", "Defects in cobalamin b12 metabolism", "Defects in vitamin and cofactor metabolism", "Defects of contact activation system cas and kallikrein kinin system kks", "Defensins", "Degradation of axin", "Degradation of beta catenin by the destruction complex", "Degradation of cysteine and homocysteine", "Degradation of dvl", "Degradation of gli1 by the proteasome", "Degradation of the extracellular matrix", "Depolymerisation of the nuclear lamina", "Deposition of new cenpa containing nucleosomes at the centromere", "Detoxification of reactive oxygen species", "Deubiquitination", "Developmental biology", "Dex h box helicases activate type i ifn and inflammatory cytokines production", "Digestion", "Digestion and absorption", "Disassembly of the destruction complex and recruitment of axin to the membrane", "Diseases associated with glycosaminoglycan metabolism", "Diseases associated with glycosylation precursor biosynthesis", "Diseases associated with n glycosylation of proteins", "Diseases associated with o glycosylation of proteins", "Diseases of carbohydrate metabolism", "Diseases of dna repair", "Diseases of glycosylation", "Diseases of immune system", "Diseases of metabolism", "Diseases of mismatch repair mmr", "Diseases of mitotic cell cycle", "Diseases of programmed cell death", "Diseases of signal transduction by growth factor receptors and second messengers", "Disinhibition of snare formation", "Disorders of transmembrane transporters", "Displacement of dna glycosylase by apex1", "Dissolution of fibrin clot", "Dna damage bypass", "Dna damage recognition in gg ner", "Dna damage reversal", "Dna damage telomere stress induced senescence", "Dna double strand break repair", "Dna double strand break response", "Dna methylation", "Dna repair", "Dna replication", "Dna replication initiation", "Dna replication pre initiation", "Dna strand elongation", "Dopamine clearance from the synaptic cleft", "Dopamine neurotransmitter release cycle", "Downregulation of erbb2 erbb3 signaling", "Downregulation of erbb2 signaling", "Downregulation of erbb4 signaling", "Downregulation of smad2 3 smad4 transcriptional activity", "Downregulation of tgf beta receptor signaling", "Downstream signal transduction", "Downstream signaling events of b cell receptor bcr", "Downstream signaling of activated fgfr1", "Downstream signaling of activated fgfr2", "Downstream signaling of activated fgfr3", "Downstream signaling of activated fgfr4", "Dscam interactions", "Dual incision in gg ner", "Dual incision in tc ner", "E2f enabled inhibition of pre replication complex formation", "E2f mediated regulation of dna replication", "E3 ubiquitin ligases ubiquitinate target proteins", "Early phase of hiv life cycle", "Ecm proteoglycans", "Effects of pip2 hydrolysis", "Egfr downregulation", "Egfr interacts with phospholipase c gamma", "Egfr transactivation by gastrin", "Egr2 and sox10 mediated initiation of schwann cell myelination", "Elastic fibre formation", "Endogenous sterols", "Endosomal sorting complex required for transport escrt", "Endosomal vacuolar pathway", "Energy dependent regulation of mtor by lkb1 ampk", "Enos activation", "Eph ephrin mediated repulsion of cells", "Eph ephrin signaling", "Epha mediated growth cone collapse", "Ephb mediated forward signaling", "Ephrin signaling", "Epigenetic regulation of gene expression", "Er quality control compartment erqc", "Er to golgi anterograde transport", "Erbb2 regulates cell motility", "Ercc6 csb and ehmt2 g9a positively regulate rrna expression", "Erk mapk targets", "Erks are inactivated", "Erythropoietin activates phospholipase c gamma plcg", "Erythropoietin activates ras", "Esr mediated signaling", "Establishment of sister chromatid cohesion", "Estrogen biosynthesis", "Estrogen dependent gene expression", "Estrogen dependent nuclear events downstream of esr membrane signaling", "Estrogen stimulated signaling through prkcz", "Ethanol oxidation", "Eukaryotic translation elongation", "Eukaryotic translation initiation", "Export of viral ribonucleoproteins from nucleus", "Extension of telomeres", "Extra nuclear estrogen signaling", "Extracellular matrix organization", "Factors involved in megakaryocyte development and platelet production", "Fanconi anemia pathway", "Fasl cd95l signaling", "Fatty acid metabolism", "Fatty acyl coa biosynthesis", "Fbxw7 mutants and notch1 in cancer", "Fc epsilon receptor fceri signaling", "Fceri mediated ca 2 mobilization", "Fceri mediated mapk activation", "Fceri mediated nf kb activation", "Fcgamma receptor fcgr dependent phagocytosis", "Fcgr3a mediated il10 synthesis", "Fgfr1 mutant receptor activation", "Fgfr2 alternative splicing", "Fgfr2 mutant receptor activation", "Fibronectin matrix formation", "Flt3 signaling", "Flt3 signaling in disease", "Folding of actin by cct tric", "Formation of apoptosome", "Formation of atp by chemiosmotic coupling", "Formation of fibrin clot clotting cascade", "Formation of incision complex in gg ner", "Formation of rna pol ii elongation complex", "Formation of senescence associated heterochromatin foci sahf", "Formation of tc ner pre incision complex", "Formation of the beta catenin tcf transactivating complex", "Formation of the cornified envelope", "Formation of the early elongation complex", "Formation of tubulin folding intermediates by cct tric", "Formation of xylulose 5 phosphate", "Formyl peptide receptors bind formyl peptides and many other ligands", "Foxo mediated transcription", "Foxo mediated transcription of oxidative stress metabolic and neuronal genes", "Free fatty acids regulate insulin secretion", "Frs mediated fgfr1 signaling", "Frs mediated fgfr2 signaling", "Frs mediated fgfr3 signaling", "Frs mediated fgfr4 signaling", "Fructose metabolism", "G alpha 12 13 signalling events", "G alpha i signalling events", "G alpha q signalling events", "G alpha s signalling events", "G alpha z signalling events", "G beta gamma signalling through cdc42", "G beta gamma signalling through pi3kgamma", "G protein activation", "G protein beta gamma signalling", "G protein mediated events", "G0 and early g1", "G1 s dna damage checkpoints", "G1 s specific transcription", "G2 m checkpoints", "G2 m dna damage checkpoint", "G2 m dna replication checkpoint", "G2 phase", "Gab1 signalosome", "Gaba b receptor activation", "Gaba receptor activation", "Gaba synthesis release reuptake and degradation", "Galactose catabolism", "Gamma carboxylation hypusine formation and arylsulfatase activation", "Gamma carboxylation transport and amino terminal cleavage of proteins", "Gap filling dna repair synthesis and ligation in gg ner", "Gap junction assembly", "Gap junction degradation", "Gap junction trafficking and regulation", "Gastrin creb signalling pathway via pkc and mapk", "Gdp fucose biosynthesis", "Gene and protein expression by jak stat signaling after interleukin 12 stimulation", "Gene silencing by rna", "Generation of second messenger molecules", "Global genome nucleotide excision repair gg ner", "Glucagon like peptide 1 glp1 regulates insulin secretion", "Glucagon signaling in metabolic regulation", "Glucagon type ligand receptors", "Gluconeogenesis", "Glucose metabolism", "Glucuronidation", "Glutamate and glutamine metabolism", "Glutamate neurotransmitter release cycle", "Glutathione conjugation", "Glutathione synthesis and recycling", "Glycerophospholipid biosynthesis", "Glycerophospholipid catabolism", "Glycogen breakdown glycogenolysis", "Glycogen metabolism", "Glycogen storage diseases", "Glycogen synthesis", "Glycolysis", "Glycosaminoglycan metabolism", "Glycosphingolipid metabolism", "Glyoxylate metabolism and glycine degradation", "Golgi associated vesicle biogenesis", "Golgi cisternae pericentriolar stack reorganization", "Golgi to er retrograde transport", "Gp1b ix v activation signalling", "Gpcr ligand binding", "Gpvi mediated activation cascade", "Grb2 events in erbb2 signaling", "Grb2 sos provides linkage to mapk signaling for integrins", "Growth hormone receptor signaling", "Hats acetylate histones", "Hcmv early events", "Hcmv infection", "Hcmv late events", "Hdacs deacetylate histones", "Hdl assembly", "Hdl clearance", "Hdms demethylate histones", "Hdr through homologous recombination hrr", "Hdr through mmej alt nhej", "Hdr through single strand annealing ssa", "Hedgehog ligand biogenesis", "Hedgehog off state", "Hedgehog on state", "Heme biosynthesis", "Heme degradation", "Heme signaling", "Hemostasis", "Heparan sulfate heparin hs gag metabolism", "Hiv elongation arrest and recovery", "Hiv infection", "Hiv life cycle", "Hiv transcription elongation", "Hiv transcription initiation", "Homologous dna pairing and strand exchange", "Homology directed repair", "Host interactions of hiv factors", "Hs gag biosynthesis", "Hs gag degradation", "Hsf1 activation", "Hsf1 dependent transactivation", "Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand", "Hur elavl1 binds and stabilizes mrna", "Hyaluronan metabolism", "Hyaluronan uptake and degradation", "Hydrolysis of lpc", "Ikk complex recruitment mediated by rip1", "Immunoregulatory interactions between a lymphoid and a non lymphoid cell", "Inactivation of cdc42 and rac1", "Inactivation of csf3 g csf signaling", "Incretin synthesis secretion and inactivation", "Infection with mycobacterium tuberculosis", "Infectious disease", "Inflammasomes", "Influenza infection", "Inhibition of dna recombination at telomere", "Inhibition of replication initiation of damaged dna by rb1 e2f1", "Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components", "Initiation of nuclear envelope ne reformation", "Inla mediated entry of listeria monocytogenes into host cells", "Inlb mediated entry of listeria monocytogenes into host cell", "Innate immune system", "Inositol phosphate metabolism", "Insertion of tail anchored proteins into the endoplasmic reticulum membrane", "Insulin processing", "Insulin receptor recycling", "Insulin receptor signalling cascade", "Integration of energy metabolism", "Integration of provirus", "Integrin cell surface interactions", "Integrin signaling", "Interaction between l1 and ankyrins", "Interactions of rev with host cellular proteins", "Interactions of vpr with host cellular proteins", "Interconversion of nucleotide di and triphosphates", "Interferon alpha beta signaling", "Interferon gamma signaling", "Interferon signaling", "Interleukin 1 family signaling", "Interleukin 1 signaling", "Interleukin 10 signaling", "Interleukin 12 family signaling", "Interleukin 12 signaling", "Interleukin 15 signaling", "Interleukin 17 signaling", "Interleukin 2 family signaling", "Interleukin 20 family signaling", "Interleukin 21 signaling", "Interleukin 23 signaling", "Interleukin 27 signaling", "Interleukin 3 interleukin 5 and gm csf signaling", "Interleukin 35 signalling", "Interleukin 37 signaling", "Interleukin 4 and interleukin 13 signaling", "Interleukin 6 family signaling", "Interleukin 6 signaling", "Interleukin 7 signaling", "Interleukin 9 signaling", "Interleukin receptor shc signaling", "Intra golgi and retrograde golgi to er traffic", "Intra golgi traffic", "Intracellular signaling by second messengers", "Intraflagellar transport", "Intrinsic pathway for apoptosis", "Intrinsic pathway of fibrin clot formation", "Inwardly rectifying k channels", "Ion channel transport", "Ion homeostasis", "Ion transport by p type atpases", "Ionotropic activity of kainate receptors", "Irak2 mediated activation of tak1 complex", "Irak4 deficiency tlr2 4", "Ire1alpha activates chaperones", "Irf3 mediated activation of type 1 ifn", "Irf3 mediated induction of type i ifn", "Iron uptake and transport", "Irs mediated signalling", "Jnk c jun kinases phosphorylation and activation mediated by activated human tak1", "Josephin domain dubs", "Keratan sulfate biosynthesis", "Keratan sulfate degradation", "Keratan sulfate keratin metabolism", "Keratinization", "Ketone body metabolism", "Killing mechanisms", "Kinesins", "Ksrp khsrp binds and destabilizes mrna", "L1cam interactions", "Lagging strand synthesis", "Laminin interactions", "Late endosomal microautophagy", "Ldl clearance", "Ldl remodeling", "Leishmania infection", "Lgi adam interactions", "Linoleic acid la metabolism", "Lipophagy", "Listeria monocytogenes entry into host cells", "Long term potentiation", "Loss of function of mecp2 in rett syndrome", "Loss of mecp2 binding ability to the ncor smrt complex", "Lrr flii interacting protein 1 lrrfip1 activates type i ifn production", "Lysine catabolism", "Lysosome vesicle biogenesis", "M phase", "Map2k and mapk activation", "Map3k8 tpl2 dependent mapk1 3 activation", "Mapk family signaling cascades", "Mapk targets nuclear events mediated by map kinases", "Mapk1 erk2 activation", "Mapk3 erk1 activation", "Mapk6 mapk4 signaling", "Mastl facilitates mitotic progression", "Maturation of protein 3a", "Maturation of sars cov 1 spike protein", "Maturation of sars cov 2 nucleoprotein", "Maturation of sars cov 2 spike protein", "Mecp2 regulates neuronal receptors and channels", "Mecp2 regulates transcription factors", "Mecp2 regulates transcription of neuronal ligands", "Meiosis", "Meiotic recombination", "Meiotic synapsis", "Membrane trafficking", "Met activates pi3k akt signaling", "Met activates ptk2 signaling", "Met activates ptpn11", "Met activates rap1 and rac1", "Met activates ras signaling", "Met interacts with tns proteins", "Met promotes cell motility", "Met receptor activation", "Met receptor recycling", "Metabolic disorders of biological oxidation enzymes", "Metabolism of amino acids and derivatives", "Metabolism of carbohydrates", "Metabolism of cofactors", "Metabolism of fat soluble vitamins", "Metabolism of folate and pterines", "Metabolism of ingested semet sec mesec into h2se", "Metabolism of lipids", "Metabolism of nitric oxide nos3 activation and regulation", "Metabolism of nucleotides", "Metabolism of polyamines", "Metabolism of porphyrins", "Metabolism of rna", "Metabolism of steroid hormones", "Metabolism of steroids", "Metabolism of vitamins and cofactors", "Metabolism of water soluble vitamins and cofactors", "Metal ion slc transporters", "Metalloprotease dubs", "Methionine salvage pathway", "Methylation", "Mhc class ii antigen presentation", "Microrna mirna biogenesis", "Miro gtpase cycle", "Miscellaneous transport and binding events", "Mismatch repair", "Mitochondrial biogenesis", "Mitochondrial calcium ion transport", "Mitochondrial fatty acid beta oxidation", "Mitochondrial fatty acid beta oxidation of saturated fatty acids", "Mitochondrial fatty acid beta oxidation of unsaturated fatty acids", "Mitochondrial iron sulfur cluster biogenesis", "Mitochondrial protein import", "Mitochondrial translation", "Mitochondrial trna aminoacylation", "Mitophagy", "Mitotic g1 phase and g1 s transition", "Mitotic g2 g2 m phases", "Mitotic metaphase and anaphase", "Mitotic prometaphase", "Mitotic prophase", "Mitotic spindle checkpoint", "Mitotic telophase cytokinesis", "Molecules associated with elastic fibres", "Molybdenum cofactor biosynthesis", "Mrna capping", "Mrna decay by 3 to 5 exoribonuclease", "Mrna decay by 5 to 3 exoribonuclease", "Mrna editing", "Mrna editing c to u conversion", "Mrna splicing", "Mrna splicing minor pathway", "Mtor signalling", "Mtorc1 mediated signalling", "Mucopolysaccharidoses", "Muscle contraction", "Myd88 independent tlr4 cascade", "Myoclonic epilepsy of lafora", "Myogenesis", "N glycan antennae elongation in the medial trans golgi", "N glycan trimming and elongation in the cis golgi", "N glycan trimming in the er and calnexin calreticulin cycle", "Nade modulates death signalling", "Ncam signaling for neurite out growth", "Neddylation", "Nef and signal transduction", "Nef mediated cd4 down regulation", "Nef mediated cd8 down regulation", "Nef mediated downregulation of mhc class i complex cell surface expression", "Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters", "Negative epigenetic regulation of rrna expression", "Negative feedback regulation of mapk pathway", "Negative regulation of fgfr1 signaling", "Negative regulation of fgfr2 signaling", "Negative regulation of fgfr3 signaling", "Negative regulation of fgfr4 signaling", "Negative regulation of flt3", "Negative regulation of mapk pathway", "Negative regulation of met activity", "Negative regulation of nmda receptor mediated neuronal transmission", "Negative regulation of notch4 signaling", "Negative regulation of the pi3k akt network", "Negative regulators of ddx58 ifih1 signaling", "Nephrin family interactions", "Nervous system development", "Netrin 1 signaling", "Netrin mediated repulsion signals", "Neurexins and neuroligins", "Neuronal system", "Neurotoxicity of clostridium toxins", "Neurotransmitter clearance", "Neurotransmitter receptors and postsynaptic signal transmission", "Neurotransmitter release cycle", "Neutrophil degranulation", "Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10", "Nf kb is activated and signals survival", "Ngf stimulated transcription", "Nicotinamide salvaging", "Nicotinate metabolism", "Nod1 2 signaling pathway", "Non integrin membrane ecm interactions", "Noncanonical activation of notch3", "Nonhomologous end joining nhej", "Nonsense mediated decay nmd", "Nostrin mediated enos trafficking", "Notch hlh transcription pathway", "Notch1 intracellular domain regulates transcription", "Notch2 activation and transmission of signal to the nucleus", "Notch2 intracellular domain regulates transcription", "Notch3 activation and transmission of signal to the nucleus", "Notch3 intracellular domain regulates transcription", "Notch4 activation and transmission of signal to the nucleus", "Notch4 intracellular domain regulates transcription", "Nr1h2 and nr1h3 mediated signaling", "Nr1h2 nr1h3 regulate gene expression linked to lipogenesis", "Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux", "Nrage signals death through jnk", "Nrcam interactions", "Nrif signals cell death from the nucleus", "Ns1 mediated effects on host pathways", "Ntrk2 activates rac1", "Nuclear envelope breakdown", "Nuclear envelope ne reassembly", "Nuclear events kinase and transcription factor activation", "Nuclear events stimulated by alk signaling in cancer", "Nuclear import of rev protein", "Nuclear pore complex npc disassembly", "Nuclear signaling by erbb4", "Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways", "Nucleotide biosynthesis", "Nucleotide catabolism", "Nucleotide excision repair", "Nucleotide salvage", "O linked glycosylation", "O linked glycosylation of mucins", "Oas antiviral response", "Oncogene induced senescence", "Oncogenic mapk signaling", "Opioid signalling", "Orc1 removal from chromatin", "Organelle biogenesis and maintenance", "Organic anion transporters", "Other interleukin signaling", "Other semaphorin interactions", "Ovarian tumor domain proteases", "Oxidative stress induced senescence", "P130cas linkage to mapk signaling for integrins", "P38mapk events", "P75 ntr receptor mediated signalling", "P75ntr negatively regulates cell cycle via sc1", "P75ntr recruits signalling complexes", "P75ntr regulates axonogenesis", "P75ntr signals via nf kb", "Parasite infection", "Passive transport by aquaporins", "Pcna dependent long patch base excision repair", "Pcp ce pathway", "Pd 1 signaling", "Pecam1 interactions", "Pentose phosphate pathway", "Peptide hormone metabolism", "Peptide ligand binding receptors", "Perk regulates gene expression", "Peroxisomal lipid metabolism", "Peroxisomal protein import", "Pexophagy", "Phase 0 rapid depolarisation", "Phase i functionalization of compounds", "Phase ii conjugation of compounds", "Phenylalanine and tyrosine metabolism", "Phenylalanine metabolism", "Phosphate bond hydrolysis by nudt proteins", "Phospholipase c mediated cascade fgfr2", "Phospholipase c mediated cascade fgfr4", "Phospholipid metabolism", "Phosphorylation of emi1", "Phosphorylation of the apc c", "Pi 3k cascade fgfr1", "Pi 3k cascade fgfr2", "Pi 3k cascade fgfr3", "Pi 3k cascade fgfr4", "Pi metabolism", "Pi3k akt signaling in cancer", "Pi3k events in erbb2 signaling", "Pi5p regulates tp53 acetylation", "Pink1 prkn mediated mitophagy", "Piwi interacting rna pirna biogenesis", "Pka activation in glucagon signalling", "Pka mediated phosphorylation of creb", "Pka mediated phosphorylation of key metabolic factors", "Pkmts methylate histone lysines", "Plasma lipoprotein assembly", "Plasma lipoprotein assembly remodeling and clearance", "Plasma lipoprotein clearance", "Plasma lipoprotein remodeling", "Platelet activation signaling and aggregation", "Platelet adhesion to exposed collagen", "Platelet aggregation plug formation", "Platelet calcium homeostasis", "Platelet homeostasis", "Platelet sensitization by ldl", "Polb dependent long patch base excision repair", "Polo like kinase mediated events", "Polymerase switching", "Polymerase switching on the c strand of the telomere", "Positive epigenetic regulation of rrna expression", "Post chaperonin tubulin folding pathway", "Post translational modification synthesis of gpi anchored proteins", "Post translational protein modification", "Postmitotic nuclear pore complex npc reformation", "Potassium channels", "Potential therapeutics for sars", "Pou5f1 oct4 sox2 nanog activate genes related to proliferation", "Pp2a mediated dephosphorylation of key metabolic factors", "Prc2 methylates histones and dna", "Pre notch expression and processing", "Pre notch processing in golgi", "Pregnenolone biosynthesis", "Presynaptic function of kainate receptors", "Prevention of phagosomal lysosomal fusion", "Processing and activation of sumo", "Processing of capped intron containing pre mrna", "Processing of capped intronless pre mrna", "Processing of dna double strand break ends", "Processing of intronless pre mrnas", "Processing of smdt1", "Processive synthesis on the c strand of the telomere", "Processive synthesis on the lagging strand", "Programmed cell death", "Prolactin receptor signaling", "Prolonged erk activation events", "Propionyl coa catabolism", "Prostacyclin signalling through prostacyclin receptor", "Protein folding", "Protein localization", "Protein methylation", "Protein protein interactions at synapses", "Protein repair", "Protein ubiquitination", "Proton coupled monocarboxylate transport", "Pten regulation", "Ptk6 expression", "Ptk6 regulates cell cycle", "Ptk6 regulates proteins involved in rna processing", "Ptk6 regulates rho gtpases ras gtpase and map kinases", "Purine catabolism", "Purine ribonucleoside monophosphate biosynthesis", "Purine salvage", "Purinergic signaling in leishmaniasis infection", "Pyrimidine salvage", "Pyroptosis", "Pyruvate metabolism", "Pyruvate metabolism and citric acid tca cycle", "Ra biosynthesis pathway", "Rab gefs exchange gtp for gdp on rabs", "Rab geranylgeranylation", "Rab regulation of trafficking", "Rac1 gtpase cycle", "Rac2 gtpase cycle", "Rac3 gtpase cycle", "Raf activation", "Raf independent mapk1 3 activation", "Rap1 signalling", "Ras activation upon ca2 influx through nmda receptor", "Ras processing", "Ras signaling downstream of nf1 loss of function variants", "Reactions specific to the complex n glycan synthesis pathway", "Receptor mediated mitophagy", "Receptor type tyrosine protein phosphatases", "Recognition and association of dna glycosylase with site containing an affected purine", "Recognition of dna damage by pcna containing replication complex", "Recruitment of mitotic centrosome proteins and complexes", "Recruitment of numa to mitotic centrosomes", "Recycling of eif2 gdp", "Recycling pathway of l1", "Reduction of cytosolic ca levels", "Regulated necrosis", "Regulated proteolysis of p75ntr", "Regulation by c flip", "Regulation of bach1 activity", "Regulation of beta cell development", "Regulation of cholesterol biosynthesis by srebp srebf", "Regulation of commissural axon pathfinding by slit and robo", "Regulation of cytoskeletal remodeling and cell spreading by ipp complex components", "Regulation of expression of slits and robos", "Regulation of foxo transcriptional activity by acetylation", "Regulation of fzd by ubiquitination", "Regulation of gene expression in beta cells", "Regulation of gene expression in late stage branching morphogenesis pancreatic bud precursor cells", "Regulation of glucokinase by glucokinase regulatory protein", "Regulation of glycolysis by fructose 2 6 bisphosphate metabolism", "Regulation of hmox1 expression and activity", "Regulation of hsf1 mediated heat shock response", "Regulation of ifna signaling", "Regulation of ifng signaling", "Regulation of innate immune responses to cytosolic dna", "Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps", "Regulation of insulin secretion", "Regulation of kit signaling", "Regulation of lipid metabolism by pparalpha", "Regulation of localization of foxo transcription factors", "Regulation of mecp2 expression and activity", "Regulation of mrna stability by proteins that bind au rich elements", "Regulation of plk1 activity at g2 m transition", "Regulation of pten gene transcription", "Regulation of pten localization", "Regulation of pten mrna translation", "Regulation of pten stability and activity", "Regulation of pyruvate dehydrogenase pdh complex", "Regulation of ras by gaps", "Regulation of runx1 expression and activity", "Regulation of runx2 expression and activity", "Regulation of runx3 expression and activity", "Regulation of signaling by cbl", "Regulation of tlr by endogenous ligand", "Regulation of tnfr1 signaling", "Regulation of tp53 activity", "Regulation of tp53 activity through acetylation", "Regulation of tp53 activity through association with co factors", "Regulation of tp53 activity through methylation", "Regulation of tp53 activity through phosphorylation", "Regulation of tp53 expression and degradation", "Release of apoptotic factors from the mitochondria", "Repression of wnt target genes", "Reproduction", "Resolution of abasic sites ap sites", "Resolution of ap sites via the multiple nucleotide patch replacement pathway", "Resolution of d loop structures", "Resolution of d loop structures through synthesis dependent strand annealing sdsa", "Resolution of sister chromatid cohesion", "Respiratory electron transport", "Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins", "Response of eif2ak1 hri to heme deficiency", "Response of eif2ak4 gcn2 to amino acid deficiency", "Response of mtb to phagocytosis", "Response to elevated platelet cytosolic ca2", "Ret signaling", "Retrograde neurotrophin signalling", "Retrograde transport at the trans golgi network", "Rho gtpase cycle", "Rho gtpase effectors", "Rho gtpases activate cit", "Rho gtpases activate formins", "Rho gtpases activate iqgaps", "Rho gtpases activate ktn1", "Rho gtpases activate nadph oxidases", "Rho gtpases activate paks", "Rho gtpases activate pkns", "Rho gtpases activate rocks", "Rho gtpases activate wasps and waves", "Rhoa gtpase cycle", "Rhob gtpase cycle", "Rhobtb gtpase cycle", "Rhobtb1 gtpase cycle", "Rhobtb2 gtpase cycle", "Rhobtb3 atpase cycle", "Rhoc gtpase cycle", "Rhod gtpase cycle", "Rhof gtpase cycle", "Rhog gtpase cycle", "Rhoh gtpase cycle", "Rhoj gtpase cycle", "Rhoq gtpase cycle", "Rhot1 gtpase cycle", "Rhou gtpase cycle", "Rhov gtpase cycle", "Rip mediated nfkb activation via zbp1", "Ripk1 mediated regulated necrosis", "Rmts methylate histone arginines", "Rna polymerase i promoter escape", "Rna polymerase i transcription", "Rna polymerase i transcription initiation", "Rna polymerase i transcription termination", "Rna polymerase ii transcribes snrna genes", "Rna polymerase ii transcription", "Rna polymerase ii transcription termination", "Rna polymerase iii chain elongation", "Rna polymerase iii transcription", "Rna polymerase iii transcription initiation from type 1 promoter", "Rna polymerase iii transcription initiation from type 3 promoter", "Rna polymerase iii transcription termination", "Rnd1 gtpase cycle", "Rnd2 gtpase cycle", "Rnd3 gtpase cycle", "Robo receptors bind akap5", "Role of abl in robo slit signaling", "Role of lat2 ntal lab on calcium mobilization", "Role of phospholipids in phagocytosis", "Role of second messengers in netrin 1 signaling", "Rora activates gene expression", "Ros and rns production in phagocytes", "Rrna modification in the mitochondrion", "Rrna modification in the nucleus and cytosol", "Rrna processing", "Rrna processing in the mitochondrion", "Rsk activation", "Runx1 and foxp3 control the development of regulatory t lymphocytes tregs", "Runx1 interacts with co factors whose precise effect on runx1 targets is not known", "Runx1 regulates estrogen receptor mediated transcription", "Runx1 regulates expression of components of tight junctions", "Runx1 regulates genes involved in megakaryocyte differentiation and platelet function", "Runx1 regulates transcription of genes involved in bcr signaling", "Runx1 regulates transcription of genes involved in differentiation of hscs", "Runx1 regulates transcription of genes involved in differentiation of keratinocytes", "Runx1 regulates transcription of genes involved in differentiation of myeloid cells", "Runx1 regulates transcription of genes involved in interleukin signaling", "Runx1 regulates transcription of genes involved in wnt signaling", "Runx2 regulates bone development", "Runx2 regulates chondrocyte maturation", "Runx2 regulates genes involved in cell migration", "Runx2 regulates osteoblast differentiation", "Runx3 regulates cdkn1a transcription", "Runx3 regulates immune response and cell migration", "Runx3 regulates notch signaling", "Runx3 regulates p14 arf", "Runx3 regulates wnt signaling", "S phase", "Sars cov 1 infection", "Sars cov 2 infection", "Sars cov infections", "Scavenging by class a receptors", "Scavenging by class b receptors", "Scavenging by class f receptors", "Scavenging of heme from plasma", "Scf skp2 mediated degradation of p27 p21", "Sealing of the nuclear envelope ne by escrt iii", "Selective autophagy", "Selenoamino acid metabolism", "Sema3a pak dependent axon repulsion", "Sema3a plexin repulsion signaling by inhibiting integrin adhesion", "Sema4d in semaphorin signaling", "Sema4d induced cell migration and growth cone collapse", "Sema4d mediated inhibition of cell attachment and migration", "Semaphorin interactions", "Senescence associated secretory phenotype sasp", "Sensing of dna double strand breaks", "Sensory perception", "Sensory processing of sound", "Sensory processing of sound by outer hair cells of the cochlea", "Separation of sister chromatids", "Serine biosynthesis", "Shc mediated cascade fgfr1", "Shc mediated cascade fgfr3", "Shc mediated cascade fgfr4", "Shc related events triggered by igf1r", "Shc1 events in egfr signaling", "Shc1 events in erbb2 signaling", "Shc1 events in erbb4 signaling", "Sialic acid metabolism", "Signal amplification", "Signal attenuation", "Signal regulatory protein family interactions", "Signal transduction by l1", "Signaling by activin", "Signaling by alk", "Signaling by alk in cancer", "Signaling by bmp", "Signaling by braf and raf1 fusions", "Signaling by csf3 g csf", "Signaling by ctnnb1 phospho site mutants", "Signaling by cytosolic fgfr1 fusion mutants", "Signaling by egfr", "Signaling by egfr in cancer", "Signaling by erbb2", "Signaling by erbb2 ecd mutants", "Signaling by erbb2 in cancer", "Signaling by erbb4", "Signaling by erythropoietin", "Signaling by fgfr", "Signaling by fgfr in disease", "Signaling by fgfr1", "Signaling by fgfr1 in disease", "Signaling by fgfr2", "Signaling by fgfr2 iiia tm", "Signaling by fgfr2 in disease", "Signaling by fgfr3", "Signaling by fgfr3 fusions in cancer", "Signaling by fgfr4", "Signaling by fgfr4 in disease", "Signaling by flt3 fusion proteins", "Signaling by flt3 itd and tkd mutants", "Signaling by gpcr", "Signaling by hedgehog", "Signaling by hippo", "Signaling by insulin receptor", "Signaling by interleukins", "Signaling by kit in disease", "Signaling by leptin", "Signaling by mapk mutants", "Signaling by met", "Signaling by moderate kinase activity braf mutants", "Signaling by mras complex mutants", "Signaling by nodal", "Signaling by notch", "Signaling by notch1", "Signaling by notch1 pest domain mutants in cancer", "Signaling by notch2", "Signaling by notch3", "Signaling by notch4", "Signaling by ntrk2 trkb", "Signaling by ntrk3 trkc", "Signaling by ntrks", "Signaling by nuclear receptors", "Signaling by pdgf", "Signaling by pdgfr in disease", "Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants", "Signaling by ptk6", "Signaling by receptor tyrosine kinases", "Signaling by retinoic acid", "Signaling by rho gtpases miro gtpases and rhobtb3", "Signaling by robo receptors", "Signaling by scf kit", "Signaling by tgf beta receptor complex", "Signaling by tgf beta receptor complex in cancer", "Signaling by tgfb family members", "Signaling by the b cell receptor bcr", "Signaling by type 1 insulin like growth factor 1 receptor igf1r", "Signaling by vegf", "Signaling by wnt", "Signaling by wnt in cancer", "Signalling to erks", "Signalling to ras", "Sirt1 negatively regulates rrna expression", "Slbp dependent processing of replication dependent histone pre mrnas", "Slc mediated transmembrane transport", "Slc transporter disorders", "Smac xiap regulated apoptotic response", "Smad2 smad3 smad4 heterotrimer regulates transcription", "Small interfering rna sirna biogenesis", "Smooth muscle contraction", "Snrnp assembly", "Sodium calcium exchangers", "Sodium proton exchangers", "Sos mediated signalling", "Sphingolipid de novo biosynthesis", "Sphingolipid metabolism", "Spry regulation of fgf signaling", "Srp dependent cotranslational protein targeting to membrane", "Stabilization of p53", "Stat3 nuclear events downstream of alk signaling", "Stat5 activation", "Stat5 activation downstream of flt3 itd mutants", "Stimuli sensing channels", "Sting mediated induction of host immune responses", "Striated muscle contraction", "Sulfide oxidation to sulfate", "Sulfur amino acid metabolism", "Sumo is conjugated to e1 uba2 sae1", "Sumo is transferred from e1 to e2 ube2i ubc9", "Sumoylation", "Sumoylation of chromatin organization proteins", "Sumoylation of dna damage response and repair proteins", "Sumoylation of dna methylation proteins", "Sumoylation of dna replication proteins", "Sumoylation of rna binding proteins", "Sumoylation of sumoylation proteins", "Sumoylation of transcription cofactors", "Sumoylation of transcription factors", "Sumoylation of ubiquitinylation proteins", "Suppression of apoptosis", "Suppression of phagosomal maturation", "Surfactant metabolism", "Switching of origins to a post replicative state", "Synaptic adhesion like molecules", "Syndecan interactions", "Synthesis of 5 eicosatetraenoic acids", "Synthesis of active ubiquitin roles of e1 and e2 enzymes", "Synthesis of bile acids and bile salts", "Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol", "Synthesis of diphthamide eef2", "Synthesis of dna", "Synthesis of epoxy eet and dihydroxyeicosatrienoic acids dhet", "Synthesis of gdp mannose", "Synthesis of ip2 ip and ins in the cytosol", "Synthesis of ip3 and ip4 in the cytosol", "Synthesis of ketone bodies", "Synthesis of leukotrienes lt and eoxins ex", "Synthesis of lipoxins lx", "Synthesis of pa", "Synthesis of pc", "Synthesis of pe", "Synthesis of pg", "Synthesis of pi", "Synthesis of pips at the early endosome membrane", "Synthesis of pips at the er membrane", "Synthesis of pips at the golgi membrane", "Synthesis of pips at the late endosome membrane", "Synthesis of pips at the plasma membrane", "Synthesis of prostaglandins pg and thromboxanes tx", "Synthesis of pyrophosphates in the cytosol", "Synthesis of substrates in n glycan biosythesis", "Synthesis of udp n acetyl glucosamine", "Synthesis of very long chain fatty acyl coas", "Synthesis secretion and deacylation of ghrelin", "Synthesis secretion and inactivation of glucagon like peptide 1 glp 1", "Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip", "Tak1 activates nfkb by phosphorylation and activation of ikks complex", "Tbc rabgaps", "Tcf dependent signaling in response to wnt", "Tcr signaling", "Telomere c strand lagging strand synthesis", "Telomere c strand synthesis initiation", "Telomere extension by telomerase", "Telomere maintenance", "Termination of translesion dna synthesis", "Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation", "Tfap2 ap 2 family regulates transcription of growth factors and their receptors", "Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation", "Tgf beta receptor signaling activates smads", "Tgf beta receptor signaling in emt epithelial to mesenchymal transition", "The activation of arylsulfatases", "The canonical retinoid cycle in rods twilight vision", "The citric acid tca cycle and respiratory electron transport", "The nlrp3 inflammasome", "The phototransduction cascade", "The role of gtse1 in g2 m progression after g2 checkpoint", "The role of nef in hiv 1 replication and disease pathogenesis", "Thrombin signalling through proteinase activated receptors pars", "Thromboxane signalling through tp receptor", "Ticam1 dependent activation of irf3 irf7", "Ticam1 rip1 mediated ikk complex recruitment", "Ticam1 traf6 dependent induction of tak1 complex", "Tie2 signaling", "Tight junction interactions", "Tlr3 mediated ticam1 dependent programmed cell death", "Tnf signaling", "Tnfr1 induced nfkappab signaling pathway", "Tnfr1 induced proapoptotic signaling", "Tnfr1 mediated ceramide production", "Tnfr2 non canonical nf kb pathway", "Toll like receptor 9 tlr9 cascade", "Toll like receptor cascades", "Toll like receptor tlr1 tlr2 cascade", "Toxicity of botulinum toxin type d botd", "Tp53 regulates metabolic genes", "Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "Tp53 regulates transcription of caspase activators and caspases", "Tp53 regulates transcription of cell cycle genes", "Tp53 regulates transcription of cell death genes", "Tp53 regulates transcription of death receptors and ligands", "Tp53 regulates transcription of dna repair genes", "Tp53 regulates transcription of genes involved in cytochrome c release", "Tp53 regulates transcription of genes involved in g1 cell cycle arrest", "Tp53 regulates transcription of genes involved in g2 cell cycle arrest", "Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain", "Traf3 dependent irf activation pathway", "Traf6 mediated induction of tak1 complex within tlr4 complex", "Traf6 mediated irf7 activation", "Traf6 mediated nf kb activation", "Trafficking and processing of endosomal tlr", "Trafficking of ampa receptors", "Trafficking of glur2 containing ampa receptors", "Trafficking of myristoylated proteins to the cilium", "Trans golgi network vesicle budding", "Transcription coupled nucleotide excision repair tc ner", "Transcription of e2f targets under negative control by dream complex", "Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1", "Transcription of the hiv genome", "Transcriptional activation of mitochondrial biogenesis", "Transcriptional activity of smad2 smad3 smad4 heterotrimer", "Transcriptional regulation by e2f6", "Transcriptional regulation by mecp2", "Transcriptional regulation by runx1", "Transcriptional regulation by runx2", "Transcriptional regulation by runx3", "Transcriptional regulation by small rnas", "Transcriptional regulation by the ap 2 tfap2 family of transcription factors", "Transcriptional regulation by tp53", "Transcriptional regulation by ventx", "Transcriptional regulation of granulopoiesis", "Transcriptional regulation of pluripotent stem cells", "Transcriptional regulation of white adipocyte differentiation", "Transferrin endocytosis and recycling", "Translation", "Translation of replicase and assembly of the replication transcription complex", "Translation of sars cov 1 structural proteins", "Translation of sars cov 2 structural proteins", "Translesion synthesis by polh", "Translesion synthesis by polk", "Translesion synthesis by y family dna polymerases bypasses lesions on dna template", "Translocation of slc2a4 glut4 to the plasma membrane", "Transmission across chemical synapses", "Transport and synthesis of paps", "Transport of bile salts and organic acids metal ions and amine compounds", "Transport of connexons to the plasma membrane", "Transport of fatty acids", "Transport of inorganic cations anions and amino acids oligopeptides", "Transport of mature mrnas derived from intronless transcripts", "Transport of mature transcript to cytoplasm", "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "Transport of nucleotide sugars", "Transport of small molecules", "Transport of the slbp dependant mature mrna", "Transport of vitamins nucleosides and related molecules", "Transport to the golgi and subsequent modification", "Trif mediated programmed cell death", "Triglyceride catabolism", "Triglyceride metabolism", "Tristetraprolin ttp zfp36 binds and destabilizes mrna", "Trna aminoacylation", "Trna modification in the mitochondrion", "Trna modification in the nucleus and cytosol", "Trna processing", "Trna processing in the mitochondrion", "Trna processing in the nucleus", "Trp channels", "Tryptophan catabolism", "Type i hemidesmosome assembly", "Tyrosine catabolism", "Tysnd1 cleaves peroxisomal proteins", "Ub specific processing proteases", "Uch proteinases", "Unblocking of nmda receptors glutamate binding and activation", "Unfolded protein response upr", "Unwinding of dna", "Uptake and actions of bacterial toxins", "Uptake and function of anthrax toxins", "Uptake and function of diphtheria toxin", "Urea cycle", "Vasopressin regulates renal water homeostasis via aquaporins", "Vegfr2 mediated cell proliferation", "Vegfr2 mediated vascular permeability", "Vesicle mediated transport", "Viral messenger rna synthesis", "Visual phototransduction", "Vitamin b1 thiamin metabolism", "Vitamin b2 riboflavin metabolism", "Vitamin b5 pantothenate metabolism", "Vitamin c ascorbate metabolism", "Vitamin d calciferol metabolism", "Vldl assembly", "Vldlr internalisation and degradation", "Vxpx cargo targeting to cilium", "Wax and plasmalogen biosynthesis", "Wnt ligand biogenesis and trafficking", "Wnt mediated activation of dvl", "Wnt5a dependent internalization of fzd2 fzd5 and ror2", "Wnt5a dependent internalization of fzd4", "Zbp1 dai mediated induction of type i ifns", "Zinc efflux and compartmentalization by the slc30 family", "Zinc transporters"], "available_proteins": ["AAAS", "AACS", "AAMP", "AARS", "AARS2", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ABRAXAS2", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AGTRAP", "AHCTF1", "AHCY", "AHCYL1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK6", "AKAP1", "AKAP12", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG5", "ALKBH5", "ALYREF", "AMOT", "AMPD2", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKLE2", "ANLN", "ANO6", "ANP32A", "ANXA1", "ANXA2", "ANXA6", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3M1", "AP3S1", "APEH", "APEX1", "APLP2", "APOBEC3C", "APOOL", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARHGEF7", "ARID1A", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6", "ARL6IP5", "ARL8A", "ARMCX3", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ASAH1", "ASCC1", "ASCC3", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD2", "ATAD3B", "ATG9A", "ATIC", "ATP11C", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "B3GALT6", "B4GAT1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1B", "BCAP31", "BCAS2", "BCS1L", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPNT1", "BRD1", "BRD2", "BSG", "BUB1B", "BUB3", "BUD31", "BYSL", "C19orf70", "C1QBP", "C1orf35", "C2orf49", "CAB39", "CAD", "CALD1", "CALR", "CALU", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASK", "CAST", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC22", "CCDC8", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDKAL1", "CDS2", "CENPF", "CENPI", "CEPT1", "CERS2", "CFL1", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHEK2", "CHERP", "CHID1", "CHKA", "CHMP2A", "CHMP2B", "CHMP4B", "CHMP5", "CHMP6", "CHMP7", "CHORDC1", "CHTF18", "CHTOP", "CIAPIN1", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLINT1", "CLNS1A", "CLTA", "CLTB", "CLTC", "CMAS", "CMPK1", "CNDP2", "CNN2", "CNOT1", "CNOT7", "CNOT9", "COG2", "COG4", "COG7", "COLEC12", "COLGALT1", "COMMD4", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7B", "COPS8", "COPZ1", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF7", "CPT2", "CRKL", "CRNKL1", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSTB", "CSTF1", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC15", "CWC22", "CYB5B", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCXR", "DDA1", "DDAH2", "DDB1", "DDOST", "DDRGK1", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX52", "DDX56", "DDX6", "DEK", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS7B", "DHX15", "DHX16", "DHX36", "DHX37", "DHX38", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLGAP5", "DLST", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJB11", "DNAJC11", "DNAJC13", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK1", "DOCK7", "DOHH", "DPH5", "DPM1", "DPYSL2", "DR1", "DSG2", "DSP", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "DYNLL2", "DYNLT1", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHS1", "ECI1", "ECI2", "EDC4", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFTUD2", "EHD1", "EHMT1", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX1", "EPHX2", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERCC2", "ERCC3", "ERCC4", "ERCC6L", "ERI1", "ERLIN1", "ERLIN2", "ERO1A", "ERP44", "ESD", "ESYT1", "ETF1", "ETFA", "ETFB", "ETFDH", "EXO1", "EXOC5", "EXOC6", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM49B", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP2", "FARSA", "FARSB", "FASN", "FAU", "FBL", "FBXO7", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP1A", "FKBP4", "FKBP5", "FKBP8", "FLAD1", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FN3KRP", "FNTA", "FNTB", "FSCN1", "FTO", "FTSJ3", "FUCA1", "FUCA2", "FUS", "FXR1", "FYTTD1", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALNT1", "GALNT2", "GALNT7", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GGH", "GHDC", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLDC", "GLG1", "GLMN", "GLO1", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GM2A", "GMDS", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNG5", "GNL3", "GNPAT", "GNPDA1", "GNS", "GOLGB1", "GOLIM4", "GOLM1", "GORASP2", "GOT1", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPHN", "GPI", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GSDME", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GTF2F1", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP3", "GUSB", "GYG1", "GYS1", "H1F0", "H2AFX", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS5", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HEBP1", "HEBP2", "HECTD1", "HEXA", "HEXB", "HEXIM1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMGA1", "HMGA2", "HMGB1", "HMGB2", "HMGCR", "HMGCS1", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA12A", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPB11", "HSPD1", "HSPE1", "HSPH1", "HTT", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "ICE1", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFIT5", "IFNGR1", "IFT27", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "ILF2", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INCENP", "INTS1", "INTS13", "INTS14", "INTS3", "IPO5", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IRS4", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITM2B", "ITPA", "ITPK1", "IVD", "IWS1", "JMJD6", "JUP", "KARS", "KAT7", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIF11", "KIF14", "KIF18A", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIN", "KLC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "KTN1", "KYAT3", "LAMP1", "LAMTOR1", "LARS", "LARS2", "LAS1L", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LETM1", "LGALS3", "LGALS3BP", "LIG3", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LNPEP", "LPCAT1", "LPGAT1", "LRP1", "LRPPRC", "LRRC41", "LRSAM1", "LSM2", "LSM4", "LSM6", "LSM7", "LSM8", "LSS", "LTA4H", "LTV1", "LYPLA1", "LZTFL1", "M6PR", "MAD2L1", "MAGED2", "MAGT1", "MANBA", "MANF", "MAP2K1", "MAP2K4", "MAPK1", "MAPK14", "MAPRE1", "MARC1", "MARC2", "MARCKS", "MARS", "MAT2A", "MAT2B", "MAU2", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDC1", "MDH1", "MDH2", "ME2", "MECP2", "MED24", "MED4", "MFAP1", "MFN1", "MFN2", "MGAT1", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MIPEP", "MLEC", "MMADHC", "MMS19", "MOGS", "MORC2", "MORF4L1", "MORF4L2", "MOV10", "MPDU1", "MPG", "MPHOSPH10", "MPI", "MPP2", "MPP7", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL45", "MRPL47", "MRPL51", "MRPL53", "MRPL9", "MRPS11", "MRPS15", "MRPS17", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR6", "MTOR", "MTR", "MTX1", "MTX2", "MUT", "MYBBP1A", "MYDGF", "MYH10", "MYH9", "MYL6", "MYL6B", "MYO1C", "MYO6", "NAA35", "NAE1", "NAGLU", "NAMPT", "NANS", "NAPA", "NARS", "NAT10", "NAXE", "NBAS", "NCAPD2", "NCAPD3", "NCAPG", "NCAPH", "NCBP1", "NCKAP1", "NCL", "NCSTN", "ND1", "NDC1", "NDUFA10", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV2", "NECAP2", "NEDD4L", "NEK9", "NELFB", "NELFCD", "NELFE", "NF1", "NHLRC2", "NHP2", "NIP7", "NIPBL", "NIPSNAP2", "NIT2", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC4L", "NOL11", "NOL6", "NOL9", "NOP14", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NT5C2", "NT5C3B", "NUB1", "NUCB1", "NUDC", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NXF1", "OAT", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "OXCT1", "P3H1", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PAPSS2", "PARK7", "PARN", "PARP1", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PDAP1", "PDCD11", "PDCD4", "PDCD6", "PDCD6IP", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA6", "PDK3", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PDZD11", "PEBP1", "PECR", "PELP1", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF5A", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PICALM", "PIGK", "PIGS", "PIGT", "PIK3C2A", "PIK3R4", "PIR", "PITPNB", "PITRM1", "PKM", "PKN2", "PLA2G15", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLRG1", "PLS1", "PMPCA", "PMPCB", "PNO1", "PNP", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "PON2", "POP1", "POP7", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPID", "PPIH", "PPIL1", "PPIL4", "PPM1F", "PPOX", "PPP1CA", "PPP1CB", "PPP1R12A", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKAA1", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38A", "PRPF4", "PRPF40A", "PRPF6", "PRPF8", "PRSS3", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PTBP1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUS7", "PWP2", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QPRT", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB23", "RAB2A", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RBBP5", "RBBP6", "RBM14", "RBM17", "RBM22", "RBM28", "RBM4", "RBM5", "RBM8A", "RBMX", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RCOR1", "RDH11", "RDH13", "RDX", "REPS1", "REXO2", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RIPK1", "RNASET2", "RNF14", "RNF2", "RNF20", "RNF40", "RNMT", "RNPS1", "ROCK1", "RPA1", "RPA2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRP1", "RRP8", "RRP9", "RSF1", "RSU1", "RTCB", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "SACM1L", "SAE1", "SAFB", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SARNP", "SARS", "SARS2", "SART1", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCO1", "SCO2", "SCP2", "SCRIB", "SDHA", "SDHB", "SEC11A", "SEC13", "SEC16A", "SEC22B", "SEC23A", "SEC23IP", "SEC24A", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEH1L", "SENP3", "SEPT2", "SEPT7", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SGPL1", "SGTA", "SH3GL1", "SHMT2", "SHTN1", "SIGMAR1", "SIN3A", "SIRT1", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A26", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC2A1", "SLC30A7", "SLC35B2", "SLC38A1", "SLC3A2", "SLC7A1", "SLC7A5", "SLC9A6", "SLIT2", "SLK", "SLTM", "SMARCA4", "SMARCA5", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMN1*", "SMNDC1", "SMPD4", "SMYD3", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX2", "SNX3", "SNX5", "SNX9", "SOD2", "SORD", "SORT1", "SPAG9", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STIP1", "STMN1", "STOML2", "STRAP", "STT3A", "STUB1", "STX18", "STX4", "STX5", "STXBP3", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SURF4", "SUZ12", "SV2A", "SWAP70", "SYMPK", "SYNE2", "TAB1", "TACC3", "TAF15", "TAF2", "TAF5", "TAF6L", "TAGLN2", "TALDO1", "TAOK1", "TARS", "TARS2", "TBC1D10B", "TBC1D15", "TBC1D4", "TBC1D8B", "TBCA", "TBCB", "TBCD", "TBCE", "TBK1", "TBL3", "TCEA1", "TCP1", "TECR", "TERF2IP", "TEX10", "TFAM", "TFB1M", "TFG", "TFIP11", "TFRC", "TGOLN2", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "TIA1", "TIAL1", "TIGAR", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TJP1", "TK1", "TKT", "TLN1", "TMED10", "TMED2", "TMED5", "TMED7", "TMED9", "TMEM115", "TMOD3", "TMPO", "TMPO", "TNPO1", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TP53", "TP53BP1", "TP53BP2", "TPD52", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPRKB", "TPX2", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC4", "TRAPPC5", "TRAPPC8", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRMT10C", "TRMT11", "TRMT112", "TRMT6", "TRMU", "TRRAP", "TSFM", "TSG101", "TSNAX", "TSPO", "TSR1", "TSR3", "TST", "TSTA3", "TTC21B", "TTC26", "TTC37", "TTLL12", "TTLL4", "TTYH3", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWNK", "TXLNA", "TXNDC5", "TXNL1", "TXNL4A", "TXNRD1", "TXNRD2", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBR1", "UBR4", "UBTF", "UCHL5", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119B", "UNG", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP33", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VPS25", "VPS26A", "VPS29", "VPS33B", "VPS35", "VPS4A", "VPS4B", "VRK1", "VRK3", "VTA1", "WAPL", "WARS", "WARS2", "WBP11", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR75", "WDR77", "WFS1", "WNK1", "WTAP", "XAB2", "XPO1", "XPO5", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YARS2", "YBX1", "YEATS2", "YIF1A", "YKT6", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H11A", "ZC3HAV1", "ZC3HC1", "ZCRB1", "ZFYVE16", "ZNF512B", "ZNF638", "ZW10"], "leading_proteins": ["AAMP", "AASDHPPT", "AATF", "ABCB1", "ABHD10", "ACAD11", "ACAT2", "ACBD3", "ACOT8", "ACOX1", "ACOX3", "ACP6", "ACTN1", "ACTN4", "AGL", "AGPAT1", "AGPS", "AGTRAP", "AHCTF1", "AHCYL1", "AKT2", "ALDH3A2", "AMOT", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC5", "ANAPC7", "ANK3", "ANKLE2", "ANP32A", "ANXA1", "AP3M1", "AP3S1", "APLP2", "ARFGAP2", "ARHGEF7", "ARL2", "ASCC3", "ATP13A1", "ATP5L", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1C1", "ATP6V1E1", "B4GAT1", "BABAM2", "BAG6", "BAIAP2", "BSG", "BUB1B", "CALU", "CARM1", "CASK", "CBX1", "CCNB1", "CCNB2", "CCT7", "CDC16", "CDC23", "CDC37", "CDC42", "CDK11B", "CDK2", "CDK4", "CENPF", "CENPI", "CERS2", "CHCHD3", "CHEK2", "CHKA", "CHMP2A", "CKAP4", "COLEC12", "COMT", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "CPD", "CPNE1", "CPSF7", "CPT2", "CRKL", "CSNK1A1", "CSNK2A2", "CTBP1", "CTSA", "CTSB", "CTTN", "CYB5B", "CYP51A1", "DCAF13", "DCPS", "DCTN2", "DCTN3", "DCUN1D1", "DDB1", "DHCR24", "DHFR", "DIABLO", "DIS3", "DNAJB11", "DOHH", "DPH5", "DPM1", "DYNC1LI2", "DYNLL1", "ECE1", "ECI1", "ECI2", "EIF4B", "ELOC", "EMD", "EPHX1", "ERAP1", "ERAP2", "ERCC2", "ERLIN1", "EXO1", "EXOC5", "EXOSC6", "EXOSC8", "F11R", "FAM114A2", "FAM49B", "FASN", "FBXO7", "FDFT1", "FGFR1OP", "FIP1L1", "FKBP1A", "FLNA", "FLOT2", "FN3KRP", "FNTB", "FTO", "FUCA1", "FUCA2", "FXR1", "GAA", "GAK", "GALNT1", "GALNT7", "GBA", "GDAP1", "GGCX", "GGH", "GLA", "GLB1", "GLG1", "GLMN", "GM2A", "GMPPA", "GNG5", "GNPDA1", "GOLGB1", "GOLM1", "GPAA1", "GRB2", "GSDME", "GSTM3", "GSTO1", "GTF2F1", "GUSB", "GYS1", "HADH", "HAUS5", "HDAC1", "HDAC2", "HEXA", "HEXIM1", "HGS", "HLA-A", "HLA-B", "HLA-C", "HM13", "HMOX1", "HMOX2", "HNRNPA2B1", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPK", "HS2ST1", "HSD17B4", "HSP90AA1", "HSP90B1", "HSPB1", "HTT", "ICMT", "IDH1", "IDH2", "IFNGR1", "IFT27", "IGF2R", "ITM2B", "KDM1B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIF18A", "KIF2C", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "LBR", "LGALS3", "LGALS3BP", "LMAN2", "LNPEP", "LPCAT1", "LRP1", "LSS", "LTA4H", "MAP2K1", "MAP2K4", "MAPK14", "MAPRE1", "MARC1", "MAU2", "MBD3", "MBOAT7", "MCL1", "MIA2", "MID1", "MIF", "MOV10", "MPP2", "MRE11", "MSH2", "MSH6", "MSI2", "MSMO1", "MTAP", "MTMR6", "MTOR", "MTX1", "MYH10", "MYH9", "MYL6", "NAE1", "NAGLU", "NAMPT", "NCSTN", "ND1", "NDC1", "NDUFB3", "NDUFB9", "NDUFS2", "NLN", "NMT1", "NPC1", "NPEPPS", "NSD2", "NT5C3B", "NUCB1", 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0000000000000000000000000000000000000000..c1d6546a3d809fa78762618340ac7d5fa59df991 --- /dev/null +++ b/msigdb_wp/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2812, + "annotations_size": 586, + "title": "Average number of proteins per term", + "value": 9.319112627986348 +} \ No newline at end of file diff --git a/msigdb_wp/paths.json b/msigdb_wp/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..13c38690c286a1f037d3662011a796dd26d61418 --- /dev/null +++ b/msigdb_wp/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/msigdb_wp/fragment/C428/C428_val_log2fc"} \ No newline at end of file diff --git a/msigdb_wp/result.tsv b/msigdb_wp/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..4c20d1da1c5b9279144208b1d4f6410aaef635bf --- /dev/null +++ b/msigdb_wp/result.tsv @@ -0,0 +1,190 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Alzheimers disease 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0.0382287351538037 0.9999999998797532 0.4073097963659819 6 Q06136,Q96G23 2 +Sphingolipid metabolism overview 0.8267970332588883 2.072393756478733 0.0382287351538037 0.9999999998797532 0.4073097963659819 6 Q06136,Q96G23 2 +Cholesterol biosynthesis with skeletal dysplasias 0.8698417408791383 1.961139341088642 0.0498627705659853 0.999999999999904 0.4712836056720547 5 Q15392,Q16850 2 +Metapathway biotransformation phase i and ii 0.5753619013145372 1.926183336253316 0.0540814857707188 0.9999999999999928 0.487237967867706 19 Q86UY6,P07099,Q16850,P78417,P21266 5 +Circadian rhythm genes 0.4747993810495119 1.8909624730221395 0.0586293538668551 0.9999999999999996 0.4959856864453741 38 P04818,O14744,Q14103,P11802,Q92769,Q00839,P62136,P17844,P29375,P63208,Q13131,P49327,P43490,P54802,Q96ST3,Q03164,Q05086,Q9BWF3 18 +Netrinunc5b signaling pathway 0.6733874582889368 1.847946430592411 0.0646100927680193 1.0 0.5120142308716097 10 P62136,Q02750,Q06124,P30154 4 +Influence of laminopathies on wnt signaling 0.6861808578607269 1.7980714998975218 0.0721656779496 1.0 0.5421677856213541 9 O75844 1 +Type ii interferon signaling ifng 0.7426942568548113 1.7139276259893943 0.0865420186327838 1.0 0.6184588160830653 6 P15260,Q06124 2 +Mitochondrial complex i assembly model oxphos system 0.5263939511255655 1.669495415034022 0.0950192382863632 1.0 0.6550738074801045 20 O75306,Q96CU9,O43676 3 +Alpha 6 beta 4 signaling pathway 0.7178492358600695 1.6057194208499137 0.1083355721996293 1.0 0.6893517046953516 6 P62993,P42345,Q06124 3 +Cardiac hypertrophic response 0.6639572956554074 1.6008857199356297 0.1094022329977264 1.0 0.6893517046953516 8 Q02750,P42345,P45985,P31751 4 +Cholesterol metabolism with bloch and kandutschrussell pathways 0.5248194382028384 1.5913820164550063 0.111523629017243 1.0 0.6909067016497348 19 Q16850,Q15392,P48449,Q9BWD1,Q15800 5 +Familial partial lipodystrophy fpld 0.6575214963625341 1.5700890136631638 0.1163944041354612 1.0 0.7104908419102112 8 O60725,O75844 2 +Eicosanoid synthesis 0.8985765124555216 1.5394222833099342 0.1237012374521833 1.0 0.7152995272875913 2 Q9H7Z7 1 +Photodynamic therapyinduced nfe2l2 nrf2 survival signaling 0.8667600267244813 1.5347802351806938 0.1248378193308212 1.0 0.7152995272875913 4 P07099 1 +Vitamin d receptor pathway 0.5830475299038992 1.491823238218986 0.1357454902476726 1.0 0.7297876815150109 11 P09493,Q92783,Q96KA5,Q5VV42,P08183 5 +Fluoropyrimidine activity 0.60064984431669 1.4744375815478807 0.1403638120212225 1.0 0.7410197643642918 10 P04818,P18074,Q92820,P00374,Q06203,P31350 6 +Nrp1triggered signaling pathways in pancreatic cancer 0.6498604619176559 1.455366295854654 0.1455678819873807 1.0 0.7417632943009137 7 Q02750,P31751 2 +Familial hyperlipidemia type 3 0.8661921708185171 1.4061489684255537 0.1596798940195094 1.0 0.7733257677308474 2 Q8WTV0 1 +Progeriaassociated lipodystrophy 0.5834558364672426 1.3845964545537957 0.1661758961930948 1.0 0.7805363622184177 10 O75844 1 +Il1 signaling pathway 0.6140033904940526 1.3601092234430874 0.1737953627484536 1.0 0.7805363622184177 8 P45985,Q02750,Q15750,Q13501,Q06124 5 +Mecp2 and associated rett syndrome 0.4712361310181048 1.3517972241532354 0.1764401923946459 1.0 0.7805363622184177 21 P31943,P67809,P52597,P35637,Q96ST3 5 +Endothelin pathways 0.6266905070778733 1.3469346915669045 0.1780012672944821 1.0 0.7805363622184177 7 P42892 1 +Cellular proteostasis 0.7171276993492666 1.340484459593548 0.1800878933355134 1.0 0.7805363622184177 5 P61758,O15212,Q9NQP4 3 +Mapk cascade 0.7159410025692764 1.3355729064595891 0.1816889106932819 1.0 0.7805363622184177 5 P62993,Q02750,P45985 3 +Rala downstream regulated genes 0.8136470589296784 1.331516162420878 0.1830192304865132 1.0 0.7805363622184177 4 P16989 1 +Tcell receptor tcr signaling pathway 0.5520512879277469 1.3224599743985157 0.1860150291574522 1.0 0.7805363622184177 11 Q16539,P08670,Q02750,P62993,P46109,Q06124 6 +Photodynamic therapyinduced ap1 survival signaling 0.6514801274967283 1.3126787723847173 0.1892912135037328 1.0 0.7836625520380579 6 Q16539,Q07820,P45985 3 +Cytosine methylation 0.7069373913767029 1.298288884260191 0.1941880846377388 1.0 0.7836625520380579 5 P48735,O75874 2 +Ebola virus infection in host 0.411147495995563 1.2976066700154647 0.1944225289756866 1.0 0.7836625520380579 36 O15118,P52294,P07858,P04439 4 +Striated muscle contraction pathway 0.7030893037092563 1.2823451173791167 0.1997216075661345 1.0 0.7907896083361815 5 P08670,O43707 2 +Nephrotic syndrome 0.5268155789462152 1.243975043629385 0.2135087480536706 1.0 0.8177524598656926 12 O75844 1 +Breast cancer pathway 0.4832799435822512 1.2186815983209336 0.2229650649441075 1.0 0.8375482567772243 17 P11802,P31751,Q9UJX6,Q02750,P63208,P62993,P42345,P48729 8 +Oxidation by cytochrome p450 0.7785771034629567 1.197039787220206 0.2312910472132983 1.0 0.8427152604477418 4 Q16850 1 +Congenital generalized lipodystrophy cgl 0.8096085409252773 1.1741429256071176 0.2403377823026313 1.0 0.8427152604477418 2 P31751 1 +Follicle stimulating hormone fsh signaling pathway 0.6190127014977999 1.1680270259966754 0.2427958636109499 1.0 0.8427152604477418 6 Q9UKG1,P42345 2 +Hostpathogen interaction of human coronaviruses apoptosis 0.8064056939501891 1.1610951365532112 0.2456032123465845 1.0 0.8427152604477418 2 Q07820 1 +Mirnas involvement in the immune response in sepsis 0.8064056939501747 1.1610951365531526 0.2456032123466083 1.0 0.8427152604477418 2 Q15750 1 +Signal transduction through il1r 0.8064056939501747 1.1610951365531526 0.2456032123466083 1.0 0.8427152604477418 2 Q15750 1 +Notch signaling 0.6172881146314927 1.160336594053926 0.245911791018027 1.0 0.8427152604477418 6 Q92542,Q13363,Q92769 3 +Pancreatic adenocarcinoma pathway 0.4992982950811876 1.1511536074563231 0.2496690471814004 1.0 0.8506166374901203 13 P30086,Q02750,P11233,P31751 4 +Interleukin1 il1 structural pathway 0.6092622365755053 1.1245500941400033 0.2607797316123417 1.0 0.8571701787727691 6 Q15750,Q02750,P45985 3 +Familial hyperlipidemia type 4 0.79039145907473 1.0960765526035472 0.2730452747626049 1.0 0.8571701787727691 2 Q07954 1 +Vitamin a and carotenoid metabolism 0.8412824515821221 1.0928846498966185 0.2744444487268405 1.0 0.8571701787727691 3 Q8WTV0 1 +Neuroinflammation 0.7502242199985029 1.0886384250333017 0.276313365028118 1.0 0.8571701787727691 4 Q16539,P42345 2 +Histone modifications 0.5707393118228072 1.0834210980036003 0.2786215551880744 1.0 0.8571701787727691 7 Q9BYW2,Q01105,Q03164 3 +Endometrial cancer 0.5564159954714899 1.0793407566954505 0.2804358503444872 1.0 0.8571701787727691 8 Q9UJX6,Q02750,P31751 3 +Tryptophan metabolism 0.4864343838068445 1.0759176654445923 0.2819640806229193 1.0 0.8571701787727691 13 P51648,Q15392,Q16836 3 +Translation inhibitors in chronically activated pdgfra cells 0.4701378876262194 1.070290277541998 0.2844886693132304 1.0 0.8571701787727691 15 P45985,P31751,Q02750,P23588,Q53EL6,P42345 6 +4hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression 0.6514531629287934 1.0684192991101935 0.2853314153363819 1.0 0.8571701787727691 5 Q96KB5,Q02750,P42345 3 +Relationship between inflammation cox2 and egfr 0.8329476149766855 1.0626778703828874 0.2879280598157443 1.0 0.8571701787727691 3 Q9H7Z7 1 +Camkk2 pathway 0.5185823406794654 1.04290701576105 0.2969913600009235 1.0 0.8658554077638865 10 O76024,Q13501,P42345,P09601 4 +Head and neck squamous cell carcinoma 0.5156209718699112 1.0272950405687669 0.3042815569630961 1.0 0.878369420592977 10 P62942,P42345,Q13131,P31751 4 +Urea cycle and related diseases 0.7711743772242146 1.0186508085191996 0.3083687738607494 1.0 0.8858044190313685 2 Q9Y619 1 +Ranklrank signaling pathway 0.4833109943547179 0.9973079848824988 0.3186150391062188 1.0 0.8948626596563087 12 P31751,Q02750,Q15750,Q13501,P42345 5 +Spinal cord injury 0.4485396938713005 0.9936314495246508 0.3204023272957443 1.0 0.8948626596563087 17 Q9NQC3,P14174,P08670,P04083,P62942 5 +Disruption of postsynaptic signaling by cnv 0.5515467151593433 0.9930520885591828 0.3206845708665953 1.0 0.8948626596563087 7 Q14168,Q06787,Q07157 3 +Ketogenesis and ketolysis 0.5731348861761564 0.963861448464791 0.3351153941197089 1.0 0.9123925818192046 6 P53985 1 +Aryl hydrocarbon receptor pathway wp2873 0.6243682089786218 0.9568441551599072 0.3386459216807282 1.0 0.9123925818192046 5 Q16543 1 +Metabolism of spingolipids in er and golgi apparatus 0.8027767888928533 0.9541638079671492 0.3400007314158464 1.0 0.9123925818192046 3 Q06136,Q10472 2 +Mthfr deficiency 0.5684090133715851 0.942938560886224 0.3457123296837321 1.0 0.9123925818192046 6 P35790 1 +Adipogenesis 0.4604164262413822 0.92421120845461 0.3553763610781533 1.0 0.9123925818192046 13 O75844,P43490 2 +Erbb signaling pathway 0.4703577159908578 0.9241425361643656 0.3554121093874349 1.0 0.9123925818192046 12 P45985,P31751,Q02750,P46109,P42345 5 +Nanomaterial induced apoptosis 0.7906728373086465 0.9110882412197168 0.3622488815824376 1.0 0.9149907095142604 3 Q9NR28,O95831 2 +Vitamin d metabolism 0.783057992222627 0.8841523447068723 0.3766139796396772 1.0 0.9306811312591958 3 P04062 1 +Sterol regulatory elementbinding proteins srebp signaling 0.370979859077619 0.8676921022042247 0.3855629105774849 1.0 0.9306811312591958 28 P55735,Q16850,Q8WTV0,Q15437 4 +Epithelial to mesenchymal transition in colorectal cancer 0.4301654145024396 0.8476543222459471 0.396630511939027 1.0 0.9306811312591958 16 Q16539,Q15022,Q07157,P45985,P31751,Q02750,P62993 7 +Nucleotidebinding oligomerization domain nod pathway 0.545585554614249 0.8424530611460868 0.3995344029615126 1.0 0.9306811312591958 6 Q7L5N1,Q13685 2 +Aryl hydrocarbon receptor pathway wp2586 0.5170733479312237 0.8319169720273315 0.4054558112709139 1.0 0.9306811312591958 7 Q16543 1 +Photodynamic therapyinduced hif1 survival signaling 0.4776346747747356 0.8281505002618083 0.4075852728201425 1.0 0.9306811312591958 10 P53985 1 +Apoptosis 0.4776227359586561 0.8280884203020316 0.4076204269096171 1.0 0.9306811312591958 10 Q9NR28,Q07820 2 +Insulin signaling in adipocytes diabetic condition 0.6775356327483663 0.8153031670582693 0.4148987963764949 1.0 0.9306811312591958 4 P42345,P31751 2 +Insulin signaling in adipocytes normal condition 0.6775356327483663 0.8153031670582693 0.4148987963764949 1.0 0.9306811312591958 4 P42345,P31751 2 +Iron metabolism in placenta 0.7163701067615668 0.8032693370056967 0.4218190768584686 1.0 0.9306811312591958 2 P02786 1 +Envelope proteins and their potential roles in edmd physiopathology 0.425975794564433 0.7996341404209346 0.4239228010451148 1.0 0.9306811312591958 15 P62993,P50402,Q02750,Q14739 4 +Preimplantation embryo 0.5062913168239251 0.7820725670248978 0.4341719277865161 1.0 0.933276686853474 7 Q92945 1 +Inhibition of exosome biogenesis and secretion by manumycin a in crpc cells 0.5052972999834272 0.7774954056132106 0.4368665440325694 1.0 0.9337238591764824 7 P31943 1 +Kisspeptinkisspeptin receptor system in the ovary 0.6622642752978583 0.7593885872318077 0.4476201385873506 1.0 0.9401627283590948 4 P31751 1 +Interferon type i signaling pathways 0.4289637766018552 0.7432189180898524 0.4573491515685481 1.0 0.9537601523813852 13 Q99873,P23588,P46109,Q53EL6,P42345,Q06124 6 +Praderwilli and angelman syndrome 0.5700319608640665 0.7371516687674423 0.4610301210463239 1.0 0.9575181918148008 5 Q15154,Q7L576,P11802 3 +Type i collagen synthesis in the context of osteogenesis imperfecta 0.4438979537823704 0.7300507118814469 0.465359187293598 1.0 0.9575181918148008 11 Q32P28,P13674,O75718 3 +Proximal tubule transport 0.456382193913741 0.7184622663139528 0.4724723060115605 1.0 0.9575181918148008 10 P36543 1 +Kallmann syndrome 0.6493406406026354 0.7126767404656669 0.4760458126480313 1.0 0.958635210349644 4 Q06124 1 +Cholesterol biosynthesis pathway 0.4387359091853544 0.702467949425394 0.4823873827192995 1.0 0.962138057504886 11 P48449,Q16850 2 +Type 2 papillary renal cell carcinoma 0.465870344409274 0.6966934636933584 0.4859946502072461 1.0 0.962138057504886 9 Q15369,Q92733 2 +1q211 copy number variation syndrome 0.4755753791101652 0.6897664519202656 0.490341069001234 1.0 0.9674742977600104 8 Q9Y624,Q07157,Q9NPH0 3 +Translation factors 0.3429495225411262 0.6810242755427122 0.4958561300856043 1.0 0.9684492017624138 35 P55010,Q9H074,P23588,O75153 4 +Monoamine transport 0.6829181494661913 0.6777126969871011 0.4979538743591818 1.0 0.9684492017624138 2 Q16539 1 +Chromosomal and microsatellite instability in colorectal cancer 0.4073190843288189 0.6731845650508745 0.5008298795207429 1.0 0.9684492017624138 14 P11233,P31751,Q9UJX6,Q02750,Q9UKG1 5 +Mitochondrial long chain fatty acid betaoxidation 0.4228114076555114 0.6602030138038927 0.5091235585085285 1.0 0.9684492017624138 12 O43772,Q9BY49,P42126,Q16836 4 +Kennedy pathway from sphingolipids 0.7152029195360009 0.6518111609540097 0.5145230007673995 1.0 0.9684492017624138 3 P35790 1 +Pilocytic astrocytoma 0.7136983646113192 0.6468582188780763 0.5177237087990076 1.0 0.9684492017624138 3 Q06124 1 +Serine metabolism 0.5397563135616861 0.6190371182508072 0.5358919065575523 1.0 0.9684492017624138 5 P34897,P00374 2 +Ras signaling 0.3746933627782005 0.6186258808303985 0.5361628481152945 1.0 0.9684492017624138 20 P31751,Q02750,P11233,Q06124 4 +Triacylglyceride synthesis 0.6989692348448414 0.5989436703623252 0.5492104485580418 1.0 0.9684492017624138 3 Q99943 1 +Initiation of transcription and translation elongation at the hiv1 ltr 0.4552954914915507 0.5956122973474538 0.5514342595578863 1.0 0.9684492017624138 8 Q8IXH7,Q92769,O94992 3 +Glycogen synthesis and degradation 0.3917049567842998 0.5839079915426434 0.5592822162377318 1.0 0.9684492017624138 14 P13807,P35573,P30154 3 +B cell receptor signaling pathway 0.3986066818758118 0.5737735247428258 0.5661210667164118 1.0 0.9684492017624138 13 P62993,P46109,Q02750,Q06124 4 +Statin inhibition of cholesterol production 0.5275483669065426 0.5726943703574349 0.5668516498821536 1.0 0.9684492017624138 5 P37268,Q07954,Q8WTV0 3 +Angiopoietinlike protein 8 regulatory pathway 0.3538554118736052 0.5655629665337394 0.5716909088289079 1.0 0.9684492017624138 22 Q16539,P45985,P31751,Q02750,P49327,Q13131,P13807,P42345 8 +Regulation of wnt bcatenin signaling by small molecule compounds 0.6872238410463383 0.5615369102893418 0.5744315755436216 1.0 0.9684492017624138 3 Q07954 1 +Estrogen signaling pathway 0.6036101592336074 0.5531715317885886 0.5801459586871383 1.0 0.9684492017624138 4 Q02750 1 +Apoptosis modulation and signaling 0.4443088714738938 0.5456781199559949 0.5852872146816297 1.0 0.9684492017624138 8 Q9NR28,O95831,Q07820 3 +Common pathways underlying drug addiction 0.4743449568891288 0.5402629154927245 0.5890157293144895 1.0 0.9684492017624138 6 Q02750 1 +Cohesin complex cornelia de lange syndrome 0.3817333899218525 0.5386106904979008 0.5901555094676867 1.0 0.9684492017624138 15 P30153,O60216,P30154 3 +Splicing factor nova regulated synaptic proteins 0.3774095155351059 0.5277109528227296 0.5976999700471723 1.0 0.9684492017624138 16 Q06481 1 +Male infertility 0.3740119389132215 0.525183041346484 0.5994559528343588 1.0 0.9684492017624138 17 Q15165,P40818,P18074,P08183,Q9UFC0 5 +P38 mapk signaling pathway 0.4366087895198837 0.5112185390203935 0.6091980385705826 1.0 0.9684492017624138 8 P62993,P45985,P04792 3 +Complement system in neuronal development and plasticity 0.444814982055083 0.5077796819695521 0.6116078603016213 1.0 0.9684492017624138 7 Q5KU26,Q9NR28 2 +Synaptic signaling pathways associated with autism spectrum disorder 0.4357850839351821 0.5075607818521883 0.6117614000766809 1.0 0.9684492017624138 8 P42345,Q13131,P31751 3 +Melanoma 0.4237636568379162 0.4963449833731791 0.619651034039375 1.0 0.9684492017624138 9 P62993,Q02750,P31751 3 +Embryonic stem cell pluripotency pathways 0.4188363210766475 0.4737991839428877 0.6356431165807486 1.0 0.9684492017624138 9 P31751,Q02750,P62993,P42345,Q06124 5 +Lncrna in canonical wnt signaling and colorectal cancer 0.3912673482177362 0.4577961896562175 0.6470988735651604 1.0 0.9684492017624138 11 Q9UJX6,P61978,Q13363,Q00839 4 +Folate metabolism 0.3837602811705035 0.4547397515239287 0.6492964790191207 1.0 0.9684492017624138 12 Q8WTV0 1 +Glioblastoma signaling pathways 0.3644969335129849 0.4423616299696726 0.6582275401021531 1.0 0.9684492017624138 15 P52701,P45985,P31751,Q02750,P62993 5 +Hepatitis b infection 0.3467794047185045 0.4375794428275142 0.6616911758981456 1.0 0.9684492017624138 20 Q16539,P45985,P31751,Q9Y277,Q02750,P49327,Q15904,Q15750,P62993 9 +Fgfr3 signaling in chondrocyte proliferation and terminal differentiation 0.4897144992919476 0.435294570151172 0.6633486256752448 1.0 0.9684492017624138 5 Q02750 1 +Cannabinoid receptor signaling 0.5671530075586542 0.4346407195483087 0.6638232336259293 1.0 0.9684492017624138 4 P10644 1 +Network map of sarscov2 signaling pathway 0.3389298710551626 0.4241045772526598 0.671489547494764 1.0 0.9684492017624138 21 Q99829,Q08380,P31350,P42345,P07858 5 +Hijack of ubiquitination by sarscov2 0.4440128604501488 0.4209594037505756 0.6737847262362875 1.0 0.9684492017624138 6 Q15369 1 +Ciliopathies 0.3472951687491247 0.4073488722970743 0.6837517726460649 1.0 0.9722137428175484 19 Q8WXW3,Q15555,Q13432,O43924,Q10713,Q9BW83 6 +Physicochemical features and toxicityassociated pathways 0.377920612345835 0.3930991065229436 0.6942462839839123 1.0 0.9752218166000456 11 P45985,Q02750,P35080,P07737,P62993 5 +Fas ligand pathway and stress induction of heat shock proteins 0.3705199188604306 0.3889674287867646 0.6973002408795548 1.0 0.9752218166000456 12 P49327,Q03252,P45985,P04792 4 +Thyroid hormones production and peripheral downstream signaling effects 0.3694605767905773 0.3838124452215908 0.7011174632998713 1.0 0.9782257940326776 12 P62993,Q02750,P42345 3 +Tolllike receptor signaling pathway 0.3846029862225763 0.3702295259168857 0.711211478672896 1.0 0.989065268729035 10 Q15750,Q02750,P45985,P31751 4 +Joubert syndrome 0.3454290166877956 0.3412273560711228 0.73293243064362 1.0 1.0 15 P36404,Q8WXW3,Q13432,O43924,Q10713,P42345 6 +Eicosanoid metabolism via lipooxygenases lox 0.4596644953002212 0.3347259409187702 0.7378318311345293 1.0 1.0 5 Q14914,O15254,P09960 3 +Ferroptosis 0.3189782376753287 0.3338940671921077 0.7384594968288241 1.0 1.0 22 P45880 1 +Nanoparticlemediated activation of receptor signaling 0.419667388156575 0.3314976102160643 0.7402686458137386 1.0 1.0 6 P62993,Q02750 2 +Il6 signaling pathway 0.3847531835686889 0.32510620143064 0.7451006956256319 1.0 1.0 9 Q02750,P45985,Q06124 3 +Small cell lung cancer 0.4139948816826226 0.3116164528633536 0.7553320288652259 1.0 1.0 6 P63208,P31751 2 +Hostpathogen interaction of human coronaviruses mapk signaling 0.4118621338177205 0.3042442185246032 0.7609418390211786 1.0 1.0 6 Q02750,P45985 2 +Cell cycle 0.2952819905192356 0.3042082127573182 0.7609692682990989 1.0 1.0 45 P78527,Q9UJX4,Q9Y3B8,P11802,Q92769,Q9UBD5,Q9UJX6,Q13416,P63208,O60216,Q9Y619,Q13042,Q9UJX3,Q9H1A4,Q9UJX2,P30260 16 +Biomarkers for pyrimidine metabolism disorders 0.4484032728078073 0.2994350298720382 0.7646081375677327 1.0 1.0 5 P04818,P31350 2 +Wnt signaling pathway and pluripotency 0.344201928283688 0.2957808402474014 0.7673974559273748 1.0 1.0 13 P30153,P45985,P30154 3 +Nonalcoholic fatty liver disease 0.2956864304206478 0.292904287959145 0.7695953112132721 1.0 1.0 42 P21912,P31751,O43676,O75306,P47985 5 +Pathways affected in adenoid cystic carcinoma 0.3354615422222347 0.2910916856204282 0.7709811986443058 1.0 1.0 15 Q9BYW2,Q969G3,Q99417 3 +Oncostatin m signaling pathway 0.347612738977932 0.2815931675846382 0.7782554797705501 1.0 1.0 12 P62993,Q02750,P42345,Q06124 4 +Onecarbon metabolism and related pathways 0.3526404245974024 0.277656536408028 0.7812760280048581 1.0 1.0 11 P04818,P34897,O43865,P35790 4 +Micrornas in cardiomyocyte hypertrophy 0.3274648038660926 0.2572376275586035 0.79699533847766 1.0 1.0 16 P45985,P31751,Q02750,Q15750,P42345 5 +Effect of progerin on genes involved in hutchinsongilford progeria syndrome 0.3477431603271104 0.2565523080922663 0.7975243955009717 1.0 1.0 11 O95983,P83916 2 +Ethanol effects on histone modifications 0.3668436442782782 0.25322526569403 0.8000941434245861 1.0 1.0 9 P00374,Q92769,Q9H9T3 3 +Il2 signaling pathway 0.372129645647184 0.2471176398353617 0.804817182402265 1.0 1.0 8 P46109,Q02750,Q06124 3 +Mapk signaling pathway 0.2904558811861132 0.2432260284022 0.8078303044372956 1.0 1.0 30 Q16539,P45985,P31751,Q02750,P04792,Q15750,P62993,P46109,Q7L7X3 9 +Osteoblast differentiation and related diseases 0.3617552622190597 0.2337415873239771 0.8151855998921089 1.0 1.0 9 P78527,Q16539,P35222,P42224,P05771,Q99570,O00443,Q06330 8 +Parkinubiquitin proteasomal system pathway 0.2883789388423005 0.2274912082248401 0.8200418048617837 1.0 1.0 32 P68371,Q9BVA1,O14936,P07437 4 +Nitric oxide metabolism in cystic fibrosis 0.4235363498133357 0.2268560647090109 0.8205356666432313 1.0 1.0 5 Q86X55 1 +Hepatitis c and hepatocellular carcinoma 0.3585065258967455 0.2215357045991494 0.8246753389044645 1.0 1.0 9 P62993,Q16539,P31350,Q06124 4 +Fatty acid betaoxidation 0.3169618540446718 0.2129411823228947 0.8313728400930711 1.0 1.0 17 P42126 1 +Egfegfr signaling pathway 0.2857491626756787 0.2103797926249722 0.8333712628885963 1.0 1.0 37 P30086,P11233,Q92783,O14964,P40818,Q02750,P62993,P46109,P42345,Q06124 10 +Integrated cancer pathway 0.3348803998571869 0.2033563945993782 0.8388564797276823 1.0 1.0 11 P06493,P53350,P52701,P11802,P24941,P04637,P42224,P49959,P43246,O96017 10 +Il3 signaling pathway 0.3510782203223935 0.1943393153993904 0.8459102031799624 1.0 1.0 9 P46109,Q02750,Q06124 3 +Mitochondrial complex iii assembly 0.3500707444438814 0.190729333212453 0.8487376559623094 1.0 1.0 9 Q6DKK2 1 +Apoptosisrelated network due to altered notch3 in ovarian cancer 0.3177183349359497 0.1796972898521799 0.8573902211956668 1.0 1.0 13 P08670,Q13501,P16989 3 +Thermogenesis 0.2806054555626946 0.1676084880412887 0.8668912931815071 1.0 1.0 24 Q16539,Q969G3,O43772,Q96GM5,P62993,P23786,P42345 7 +Microglia pathogen phagocytosis pathway 0.5007117437722335 0.159873034782809 0.8729810903968906 1.0 1.0 2 O00443 1 +Regulation of sister chromatid separation at the metaphaseanaphase transition 0.3446234512581562 0.1528136213257645 0.8785452556377997 1.0 1.0 8 Q9UJX6,O60216 2 +Cancer immunotherapy by pd1 blockade 0.510532074958636 0.1302845518744471 0.8963413017118176 1.0 1.0 3 Q06124 1 +Complement and coagulation cascades 0.4750889679715261 0.1191878593350085 0.9051265249315474 1.0 1.0 2 P49257 1 +G protein signaling pathways 0.3073517155734716 0.1186324773802556 0.9055665338097396 1.0 1.0 12 O43823 1 +Ovarian infertility 0.472597864768676 0.1156987599054009 0.9078912891049972 1.0 1.0 2 P11802 1 +Serotonin htr1 group and fos pathway 0.3743985897811338 0.1083697592748447 0.9137023884366444 1.0 1.0 5 Q02750 1 +Regulation of actin cytoskeleton 0.2684093686642604 0.1048434637455541 0.9165000209962422 1.0 1.0 29 Q02750,P07737,Q9UQB8 3 +Malignant pleural mesothelioma 0.2639378092007411 0.0951725483526873 0.9241777742318652 1.0 1.0 52 Q16539,Q01650,Q9BYW2,Q07820,P45985,P31751,Q13363,Q4VCS5,Q02750,P23588,P62993,P42345 12 +Fragile x syndrome 0.2670922124689093 0.0866814094731387 0.9309247538804652 1.0 1.0 35 Q06787,P62136,Q02750,P51648,P10644,P53985,P42345,Q06124 8 +Tca cycle aka krebs or citric acid cycle 0.2873680027756629 0.083878837937821 0.9331527651359696 1.0 1.0 15 P48735 1 +Smc1smc3 role in dna damage cornelia de lange syndrome 0.3342836778332084 0.0820297150464334 0.9346230838856058 1.0 1.0 6 O60216,P49959,Q9UQE7,Q14676,Q14683 5 +Bladder cancer 0.4176506333477059 0.0820182132929803 0.9346322301376244 1.0 1.0 4 Q02750 1 +Pyrimidine metabolism and related diseases 0.3316396280280036 0.0762470863655954 0.939222522188336 1.0 1.0 6 P04818,P31350 2 +Tcell activation sarscov2 0.3214011801202833 0.0760281939131214 0.9393966676087802 1.0 1.0 7 Q02750,P42345 2 +Tumor suppressor activity of smarcb1 0.3040727451224876 0.0667378643087235 0.9467903901332 1.0 1.0 10 Q15022,Q969G3,Q96GM5 3 +Tnfalpha signaling pathway 0.2818634015621493 0.0621800667594056 0.9504194361902764 1.0 1.0 16 Q16543,P45985,Q9NR28 3 +Transsulfuration and onecarbon metabolism 0.2778067627551893 0.0479915692453831 0.9617229616340052 1.0 1.0 16 P04818,P34897,P13995,O43865,P00374 5 +Ebsteinbarr virus lmp1 signaling 0.3608540925266951 0.0301840440692859 0.97592027372222 1.0 1.0 2 P07900 1 +Omega3 omega6 fatty acid synthesis 0.3206693755474883 0.020916478733613 0.9833122813712254 1.0 1.0 5 O15254 1 +Resistin as a regulator of inflammation 0.3617053463459383 0.0191588430915415 0.9847143900260328 1.0 1.0 4 P31751 1 +Copper homeostasis 0.3830544677821333 0.0145800808658244 0.988367190731386 1.0 1.0 3 O43819,O75880 2 +Hypothesized pathways in pathogenesis of cardiovascular disease 0.3609825560697781 0.0076375731538511 0.9939061575434656 1.0 1.0 3 Q16539,P21333 2 +Ddx1 as a regulatory component of the drosha microprocessor 0.3339266642933446 0.0021913856872003 0.9982515285928284 1.0 1.0 3 Q92499,P49959 2 diff --git a/msigdb_wp/selections.json b/msigdb_wp/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..0d6b6c4d82a7e775c4d3251bece2fc640e58e036 --- /dev/null +++ b/msigdb_wp/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["15q112 copy number variation syndrome", "15q133 copy number variation syndrome", "16p112 distal deletion syndrome", "16p112 proximal deletion syndrome", "1q211 copy number variation syndrome", "22q112 copy number variation syndrome", "3q29 copy number variation syndrome", "4hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression", "7oxoc and 7betahc pathways", "7q1123 copy number variation syndrome", "Acetylcholine synthesis", "Acquired partial lipodystrophy barraquersimons syndrome", "Acute viral myocarditis", "Adipogenesis", "Aerobic glycolysis", "Aflatoxin b1 metabolism", "Agerage pathway", "Airway smooth muscle cell contraction", "Alanine and aspartate metabolism", "Allograft rejection", "Alpha 6 beta 4 signaling pathway", "Alternative pathway of fetal androgen synthesis", "Alzheimers disease", "Alzheimers disease and mirna effects", "Amino acid metabolism", "Amino acid metabolism pathway excerpt histidine catabolism extension", "Ampactivated protein kinase ampk signaling", "Amyotrophic lateral sclerosis als", "Androgen receptor signaling pathway", "Angiogenesis", "Angiopoietinlike protein 8 regulatory pathway", "Angiotensin ii receptor type 1 pathway", "Antiviral and antiinflammatory effects of nrf2 on sarscov2 pathway", "Apoptosis", "Apoptosis modulation and signaling", "Apoptosis modulation by hsp70", "Apoptosisrelated network due to altered notch3 in ovarian cancer", "Arachidonate epoxygenase epoxide hydrolase", "Arrhythmogenic right ventricular cardiomyopathy", "Aryl hydrocarbon receptor pathway wp2586", "Aryl hydrocarbon receptor pathway wp2873", "Arylamine metabolism", "Atm signaling in development and disease", "Atm signaling pathway", "Atr signaling", "Autophagy", "Autosomal recessive osteopetrosis pathways", "B cell receptor signaling pathway", "Base excision repair", "Bdnftrkb signaling", "Benzene metabolism", "Benzoapyrene metabolism", "Bile acids synthesis and enterohepatic circulation", "Biogenic amine synthesis", "Biomarkers for pyrimidine metabolism disorders", "Biomarkers for urea cycle disorders", "Biotin metabolism including iems", "Bladder cancer", "Bmp2wnt4foxo1 pathway in primary endometrial stromal cell differentiation", "Brainderived neurotrophic factor bdnf signaling pathway", "Breast cancer pathway", "Burn wound healing", "Calcium regulation in cardiac cells", "Caloric restriction and aging", "Camkk2 pathway", "Cancer immunotherapy by ctla4 blockade", "Cancer immunotherapy by pd1 blockade", "Cannabinoid receptor signaling", "Canonical and noncanonical notch signaling", "Canonical and noncanonical tgfb signaling", "Cardiac hypertrophic response", "Cardiac progenitor differentiation", "Ccl18 signaling pathway", "Cell cycle", "Cell differentiation expanded index", "Cell differentiation index", "Cell migration and invasion through p75ntr", "Cells and molecules involved in local acute inflammatory response", "Cellular proteostasis", "Cerebral organic acidurias including diseases", "Chemokine signaling pathway", "Cholesterol biosynthesis pathway", "Cholesterol biosynthesis with skeletal dysplasias", "Cholesterol metabolism with bloch and kandutschrussell pathways", "Chromosomal and microsatellite instability in colorectal cancer", "Ciliary landscape", "Ciliopathies", "Circadian rhythm genes", "Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism", "Clear cell renal cell carcinoma pathways", "Codeine and morphine metabolism", "Cohesin complex cornelia de lange syndrome", "Common pathways underlying drug addiction", "Complement and coagulation cascades", "Complement system", "Complement system in neuronal development and plasticity", "Congenital generalized lipodystrophy cgl", "Constitutive androstane receptor pathway", "Control of immune tolerance by vasoactive intestinal peptide", "Copper homeostasis", "Cori cycle", "Corticotropinreleasing hormone signaling pathway", "Cysteine and methionine catabolism", "Cytoplasmic ribosomal proteins", "Cytosine methylation", "Cytosolic dnasensing pathway", "Ddx1 as a regulatory component of the drosha microprocessor", "Degradation pathway of sphingolipids including diseases", "Deregulation of rab and rab effector genes in bladder cancer", "Development of pulmonary dendritic cells and macrophage subsets", "Development of ureteric collection system", "Disorders of folate metabolism and transport", "Disruption of postsynaptic signaling by cnv", "Dna damage response", "Dna damage response only atm dependent", "Dna irdamage and cellular response via atr", "Dna irdouble strand breaks and cellular response via atm", "Dna mismatch repair", "Dna repair pathways full network", "Dna replication", "Dopamine metabolism", "Dopaminergic neurogenesis", "Drug induction of bile acid pathway", "Dual hijack model of vif in hiv infection", "Ebola virus infection in host", "Ebsteinbarr virus lmp1 signaling", "Ectoderm differentiation", "Effect of progerin on genes involved in hutchinsongilford progeria syndrome", "Egfegfr signaling pathway", "Egfr tyrosine kinase inhibitor resistance", "Eicosanoid metabolism via cyclooxygenases cox", "Eicosanoid metabolism via cytochrome p450 monooxygenases pathway", "Eicosanoid metabolism via lipooxygenases lox", "Eicosanoid synthesis", "Electron transport chain oxphos system in mitochondria", "Embryonic stem cell pluripotency pathways", "Endochondral ossification", "Endochondral ossification with skeletal dysplasias", "Endoderm differentiation", "Endometrial cancer", "Endoplasmic reticulum stress response in coronavirus infection", "Endothelin pathways", "Energy metabolism", "Envelope proteins and their potential roles in edmd physiopathology", "Epithelial to mesenchymal transition in colorectal cancer", "Epo receptor signaling", "Erbb signaling pathway", "Erk pathway in huntingtons disease", "Estrogen metabolism", "Estrogen receptor pathway", "Estrogen signaling pathway", "Ethanol effects on histone modifications", "Ethanol metabolism production of ros by cyp2e1", "Eukaryotic transcription initiation", "Exerciseinduced circadian regulation", "Exrna mechanism of action and biogenesis", "Extracellular vesiclemediated signaling in recipient cells", "Extracellular vesicles in the crosstalk of cardiac cells", "Factors and pathways affecting insulinlike growth factor igf1akt signaling", "Familial hyperlipidemia type 1", "Familial hyperlipidemia type 2", "Familial hyperlipidemia type 3", "Familial hyperlipidemia type 4", "Familial hyperlipidemia type 5", "Familial partial lipodystrophy fpld", "Farnesoid x receptor pathway", "Fas ligand pathway and stress induction of heat shock proteins", "Fatty acid betaoxidation", "Fatty acid biosynthesis", "Fatty acid omegaoxidation", "Fatty acid transporters", "Fbxl10 enhancement of maperk signaling in diffuse large bcell lymphoma", "Ferroptosis", "Fgfr3 signaling in chondrocyte proliferation and terminal differentiation", "Fluoroacetic acid toxicity", "Fluoropyrimidine activity", "Focal adhesion", "Focal adhesion pi3kaktmtorsignaling pathway", "Folate metabolism", "Folatealcohol and cancer pathway hypotheses", "Follicle stimulating hormone fsh signaling pathway", "Foxa2 pathway", "Foxp3 in covid19", "Fragile x syndrome", "Fto obesity variant mechanism", "G protein signaling pathways", "G1 to s cell cycle control", "G13 signaling pathway", "Gaba metabolism aka ghb", "Gaba receptor signaling", "Gammaglutamyl cycle for the biosynthesis and degradation of glutathione including diseases", "Gastric cancer network 1", "Gastric cancer network 2", "Gastrin signaling pathway", "Gdnfret signaling axis", "Genes controlling nephrogenesis", "Genes related to primary cilium development based on crispr", "Glial cell differentiation", "Glioblastoma signaling pathways", "Glucocorticoid receptor pathway", "Glucuronidation", "Glutathione metabolism", "Glycerolipids and glycerophospholipids", "Glycerophospholipid biosynthetic pathway", "Glycogen synthesis and degradation", "Glycolysis and gluconeogenesis", "Glycolysis in senescence", "Glycosaminoglycan degradation", "Glycosylation and related congenital defects", "Gpcrs class a rhodopsinlike", "Gpr143 in melanocytes and retinal pigment epithelium cells", "Gpr40 pathway", "H19 action rbe2f1 signaling and cdkbetacatenin activity", "Hair follicle development cytodifferentiation part 3 of 3", "Hair follicle development organogenesis part 2 of 3", "Head and neck squamous cell carcinoma", "Heart development", "Hedgehog signaling pathway wp4249", "Hedgehog signaling pathway wp47", "Hematopoietic stem cell differentiation", "Hematopoietic stem cell gene regulation by gabp alphabeta complex", "Heme biosynthesis", "Hepatitis b infection", "Hepatitis c and hepatocellular carcinoma", "Hepatocyte growth factor receptor signaling", "Hereditary leiomyomatosis and renal cell carcinoma pathway", "Hif1a and pparg regulation of glycolysis", "Hijack of ubiquitination by sarscov2", "Hippo signaling regulation pathways", "Hippomerlin signaling dysregulation", "Hippoyap signaling pathway", "Histone modifications", "Homologous recombination", "Hostpathogen interaction of human coronaviruses apoptosis", "Hostpathogen interaction of human coronaviruses autophagy", "Hostpathogen interaction of human coronaviruses interferon induction", "Hostpathogen interaction of human coronaviruses mapk signaling", "Hypertrophy model", "Hypothesized pathways in pathogenesis of cardiovascular disease", "Id signaling pathway", "Il1 and megakaryocytes in obesity", "Il1 signaling pathway", "Il10 antiinflammatory signaling pathway", "Il17 signaling pathway", "Il18 signaling pathway", "Il2 signaling pathway", "Il3 signaling pathway", "Il4 signaling pathway", "Il5 signaling pathway", "Il6 signaling pathway", "Il7 signaling pathway", "Il9 signaling pathway", "Imatinib and chronic myeloid leukemia", "Immune response to tuberculosis", "Inclusion body myositis", "Influence of laminopathies on wnt signaling", "Inhibition of exosome biogenesis and secretion by manumycin a in crpc cells", "Initiation of transcription and translation elongation at the hiv1 ltr", "Insulin signaling", "Insulin signaling in adipocytes diabetic condition", "Insulin signaling in adipocytes normal condition", "Integrated cancer pathway", "Integrinmediated cell adhesion", "Interactions between immune cells and micrornas in tumor microenvironment", "Interactions between loxl4 and oxidative stress pathway", "Interactome of polycomb repressive complex 2 prc2", "Interferon type i signaling pathways", "Interleukin1 il1 structural pathway", "Interleukin1 induced activation of nfkb", "Interleukin11 signaling pathway", "Intracellular trafficking proteins involved in cmt neuropathy", "Intraflagellar transport proteins binding to dynein", "Irinotecan pathway", "Iron metabolism in placenta", "Joubert syndrome", "Kallmann syndrome", "Kennedy pathway from sphingolipids", "Ketogenesis and ketolysis", "Ketone bodies synthesis and degradation", "Kininkallikrein pathway", "Kisspeptinkisspeptin receptor system in the ovary", "Kit receptor signaling pathway", "Krebs cycle disorders", "Kynurenine pathway and links to cell senescence", "Leptin and adiponectin", "Leptin signaling pathway", "Leptininsulin signaling overlap", "Leukocyteintrinsic hippo pathway functions", "Lipid metabolism pathway", "Liver x receptor pathway", "Lncrna in canonical wnt signaling and colorectal cancer", "Lncrnamediated mechanisms of therapeutic resistance", "Ltf danger signal response pathway", "Lung fibrosis", "Male infertility", "Malignant pleural mesothelioma", "Mammalian disorder of sexual development", "Mammary gland development pathway embryonic development stage 1 of 4", "Mammary gland development pathway involution stage 4 of 4", "Mammary gland development pathway pregnancy and lactation stage 3 of 4", "Mammary gland development pathway puberty stage 2 of 4", "Map3k1 role in promoting and blocking gonadal determination", "Mapk and nfkb signaling pathways inhibited by yersinia yopj", "Mapk cascade", "Mapk pathway in congenital thyroid cancer", "Mapk signaling pathway", "Matrix metalloproteinases", "Mbdnf and probdnf regulation of gaba neurotransmission", "Measles virus infection", "Mechanoregulation and pathology of yaptaz via hippo and nonhippo mechanisms", "Mecp2 and associated rett syndrome", "Melanoma", "Melatonin metabolism and effects", "Mesodermal commitment pathway", "Met in type 1 papillary renal cell carcinoma", "Metabolic pathway of ldl hdl and tg including diseases", "Metabolic reprogramming in colon cancer", "Metabolism of spingolipids in er and golgi apparatus", "Metapathway biotransformation phase i and ii", "Metastatic brain tumor", "Methionine de novo and salvage pathway", "Methionine metabolism leading to sulfur amino acids and related disorders", "Methylation pathways", "Mevalonate arm of cholesterol biosynthesis pathway", "Mevalonate pathway", "Mfap5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement", "Mfap5mediated ovarian cancer cell motility and invasiveness", "Microglia pathogen phagocytosis pathway", "Microrna network associated with chronic lymphocytic leukemia", "Micrornas in cardiomyocyte hypertrophy", "Microtubule cytoskeleton regulation", "Mir124 predicted interactions with cell cycle and differentiation", "Mir517 relationship with arcn1 and usp1", "Mirna biogenesis", "Mirna regulation of dna damage response", "Mirna regulation of p53 pathway in prostate cancer", "Mirna regulation of prostate cancer signaling pathways", "Mirnas involved in dna damage response", "Mirnas involvement in the immune response in sepsis", "Mitochondrial complex i assembly model oxphos system", "Mitochondrial complex ii assembly", "Mitochondrial complex iii assembly", "Mitochondrial complex iv assembly", "Mitochondrial fatty acid synthesis pathway", "Mitochondrial gene expression", "Mitochondrial immune response to sarscov2", "Mitochondrial long chain fatty acid betaoxidation", "Modulators of tcr signaling and t cell activation", "Molybdenum cofactor moco biosynthesis", "Monoamine transport", "Mrna processing", "Mrna protein and metabolite inducation pathway by cyclosporin a", "Mthfr deficiency", "Myometrial relaxation and contraction pathways", "Nad biosynthesis ii from tryptophan", "Nad biosynthetic pathways", "Nad metabolism", "Nad metabolism in oncogeneinduced senescence and mitochondrial dysfunctionassociated senescence", "Nad metabolism sirtuins and aging", "Nanomaterial induced apoptosis", "Nanomaterialinduced inflammasome activation", "Nanoparticle triggered autophagic cell death", "Nanoparticle triggered regulated necrosis", "Nanoparticlemediated activation of receptor signaling", "Ncrnas involved in stat3 signaling in hepatocellular carcinoma", "Ncrnas involved in wnt signaling in hepatocellular carcinoma", "Neovascularisation processes", "Nephrotic syndrome", "Netrinunc5b signaling pathway", "Network map of sarscov2 signaling pathway", "Neural crest cell migration during development", "Neural crest cell migration in cancer", "Neural crest differentiation", "Neurodegeneration with brain iron accumulation nbia subtypes pathway", "Neuroinflammation", "Neuroinflammation and glutamatergic signaling", "Nicotine effect on dopaminergic neurons", "Nipbl role in dna damage cornelia de lange syndrome", "Nitric oxide metabolism in cystic fibrosis", "Nocgmppkg mediated neuroprotection", "Nonalcoholic fatty liver disease", "Nongenomic actions of 125 dihydroxyvitamin d3", "Nonhomologous end joining", "Nonsmall cell lung cancer", "Notch signaling", "Notch signaling pathway", "Notch1 regulation of endothelial cell calcification", "Novel intracellular components of rigilike receptor rlr pathway", "Nrf2 pathway", "Nrf2are regulation", "Nrp1triggered signaling pathways in pancreatic cancer", "Nsp1 from sarscov2 inhibits translation initiation in the host cell", "Nuclear receptors in lipid metabolism and toxicity", "Nuclear receptors metapathway", "Nucleotide excision repair", "Nucleotide excision repair in xeroderma pigmentosum", "Nucleotide metabolism", "Nucleotidebinding oligomerization domain nod pathway", "Oligodendrocyte specification and differentiation leading to myelin components for cns", "Omega3 omega6 fatty acid synthesis", "Omega9 fatty acid synthesis", "Oncostatin m signaling pathway", "Onecarbon metabolism", "Onecarbon metabolism and related pathways", "Orexin receptor pathway", "Osteoblast differentiation and related diseases", "Osteoclast signaling", "Osteopontin signaling", "Osx and mirnas in tooth development", "Ovarian infertility", "Overlap between signal transduction pathways contributing to lmna laminopathies", "Overview of interferonsmediated signaling pathway", "Overview of nanoparticle effects", "Oxidation by cytochrome p450", "Oxidative damage response", "Oxidative phosphorylation", "Oxidative stress response", "Oxysterols derived from cholesterol", "P38 mapk signaling pathway", "P53 transcriptional gene network", "Pancreatic adenocarcinoma pathway", "Parkinsons disease pathway", "Parkinubiquitin proteasomal system pathway", "Pathogenesis of sarscov2 mediated by nsp9nsp10 complex", "Pathogenic escherichia coli infection", "Pathways affected in adenoid cystic carcinoma", "Pathways of nucleic acid metabolism and innate immune sensing", "Pdgf pathway", "Pdgfrbeta pathway", "Pentose phosphate metabolism", "Pentose phosphate pathway in senescent cells", "Peroxiredoxin 2 induced ovarian failure", "Phase i biotransformations non p450", "Phosphodiesterases in neuronal function", "Phosphoinositides metabolism", "Photodynamic therapyinduced ap1 survival signaling", "Photodynamic therapyinduced hif1 survival signaling", "Photodynamic therapyinduced nfe2l2 nrf2 survival signaling", "Photodynamic therapyinduced unfolded protein response", "Physicochemical features and toxicityassociated pathways", "Physiological and pathological hypertrophy of the heart", "Pi3kakt signaling pathway", "Pi3kaktmtor signaling pathway and therapeutic opportunities", "Pi3kaktmtor vitd3 signaling", "Pilocytic astrocytoma", "Ppar signaling pathway", "Pparalpha pathway", "Praderwilli and angelman syndrome", "Pregnane x receptor pathway", "Preimplantation embryo", "Primary focal segmental glomerulosclerosis fsgs", "Prion disease pathway", "Progeriaassociated lipodystrophy", "Prolactin signaling pathway", "Prostaglandin and leukotriene metabolism in senescence", "Prostaglandin synthesis and regulation", "Proteasome degradation", "Proteoglycan biosynthesis", "Proximal tubule transport", "Ptf1a related regulatory pathway", "Purine metabolism", "Purine metabolism and related disorders", "Purinergic signaling", "Pyrimidine metabolism", "Pyrimidine metabolism and related diseases", "Rac1pak1p38mmp2 pathway", "Rala downstream regulated genes", "Ranklrank signaling pathway", "Ras and bradykinin pathways in covid19", "Ras signaling", "Regucalcin in proximal tubule epithelial kidney cells", "Regulation of actin cytoskeleton", "Regulation of apoptosis by parathyroid hormonerelated protein", "Regulation of sister chromatid separation at the metaphaseanaphase transition", "Regulation of wnt bcatenin signaling by small molecule compounds", "Regulatory circuits of the stat3 signaling pathway", "Relationship between inflammation cox2 and egfr", "Reninangiotensinaldosterone system raas", "Resistin as a regulator of inflammation", "Retinoblastoma gene in cancer", "Rett syndrome causing genes", "Riboflavin and coq disorders", "Robo4 and vegf signaling pathways crosstalk", "S1p receptor signal transduction", "Sars coronavirus and innate immunity", "Sarscov2 and covid19 pathway", "Sarscov2 b117 variant antagonises innate immune activation", "Sarscov2 innate immunity evasion and cellspecific immune response", "Sarscov2 replication organelle formation", "Selective expression of chemokine receptors during tcell polarization", "Selenium micronutrient network", "Serine metabolism", "Serotonin and anxiety", "Serotonin and anxietyrelated events", "Serotonin htr1 group and fos pathway", "Serotonin receptor 2 and elksrfgata4 signaling", "Serotonin receptor 467 and nr3c signaling", "Serotonin transporter activity", "Signal transduction through il1r", "Sleep regulation", "Small cell lung cancer", "Smc1smc3 role in dna damage cornelia de lange syndrome", "Somatroph axis gh and its relationship to dietary restriction and aging", "Sphingolipid metabolism in senescence", "Sphingolipid metabolism integrated pathway", "Sphingolipid metabolism overview", "Sphingolipid pathway", "Spinal cord injury", "Splicing factor nova regulated synaptic proteins", "Srebf and mir33 in cholesterol and lipid homeostasis", "Statin inhibition of cholesterol production", "Steroid biosynthesis", "Sterol regulatory elementbinding proteins srebp signaling", "Sting pathway in kawasakilike disease and covid19", "Striated muscle contraction pathway", "Sudden infant death syndrome sids susceptibility pathways", "Sulfation biotransformation reaction", "Supression of hmgb1 mediated inflammation by thbd", "Synaptic signaling pathways associated with autism spectrum disorder", "Synaptic vesicle pathway", "T cell receptor and costimulatory signaling", "Target of rapamycin tor signaling", "Tca cycle aka krebs or citric acid cycle", "Tca cycle and deficiency of pyruvate dehydrogenase complex pdhc", "Tca cycle in senescence", "Tca cycle nutrient use and invasiveness of ovarian cancer", "Tcell activation sarscov2", "Tcell antigen receptor tcr pathway during staphylococcus aureus infection", "Tcell receptor tcr signaling pathway", "Tgfbeta receptor signaling", "Tgfbeta receptor signaling in skeletal dysplasias", "Tgfbeta signaling in thyroid cells for epithelialmesenchymal transition", "Tgfbeta signaling pathway", "Thermogenesis", "Thiamine metabolic pathways", "Thymic stromal lymphopoietin tslp signaling pathway", "Thyroid hormones production and peripheral downstream signaling effects", "Thyroid stimulating hormone tsh signaling pathway", "Tlr4 signaling and tolerance", "Tnfalpha signaling pathway", "Tnfrelated weak inducer of apoptosis tweak signaling pathway", "Tolllike receptor signaling pathway", "Tolllike receptor signaling related to myd88", "Tp53 network", "Transcription cofactors ski and skil protein partners", "Transcription factor regulation in adipogenesis", "Transcription factors regulate mirnas related to cardiac hypertrophy", "Transcriptional activation by nrf2 in response to phytochemicals", "Translation factors", "Translation inhibitors in chronically activated pdgfra cells", "Transsulfuration and onecarbon metabolism", "Transsulfuration pathway", "Triacylglyceride synthesis", "Tryptophan catabolism leading to nad production", "Tryptophan metabolism", "Tumor suppressor activity of smarcb1", "Type 2 papillary renal cell carcinoma", "Type i collagen synthesis in the context of osteogenesis imperfecta", "Type i interferon induction and signaling during sarscov2 infection", "Type ii diabetes mellitus", "Type ii interferon signaling ifng", "Type iii interferon signaling", "Tyrobp causal network in microglia", "Ultraconserved region 339 modulation of tumor suppressor micrornas in cancer", "Unfolded protein response", "Urea cycle and associated pathways", "Urea cycle and metabolism of amino groups", "Urea cycle and related diseases", "Valproic acid pathway", "Vasopressinregulated water reabsorption", "Vegfavegfr2 signaling pathway", "Vitamin a and carotenoid metabolism", "Vitamin b12 disorders", "Vitamin b12 metabolism", "Vitamin b6dependent and responsive disorders", "Vitamin d in inflammatory diseases", "Vitamin d metabolism", "Vitamin d receptor pathway", "Vitamin dsensitive calcium signaling in depression", "White fat cell differentiation", "Wnt signaling", "Wnt signaling in kidney disease", "Wnt signaling pathway", "Wnt signaling pathway and pluripotency", "Wntbetacatenin signaling pathway in leukemia", "Zinc homeostasis"], "available_proteins": ["AAMP", "AAR2", "AARS", "AASS", "ABCB1", "ABCC1", "ABCD3", "ABCF1", "ABCF2", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP6", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR2", "ACTR3", "ADAR", "ADH5", "ADI1", "ADK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AKAP1", "AKAP12", "AKAP8", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "AMOT", "ANAPC1", "ANAPC2", "ANAPC5", "ANAPC7", "ANK3", "ANLN", "ANP32A", "ANXA1", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "AP1G1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "APEX1", "APLP2", "APMAP", "APPL1", "APRT", "ARCN1", "ARF4", "ARFGAP1", "ARFGAP2", "ARFIP2", "ARG2", "ARHGDIA", "ARHGEF2", "ARHGEF7", "ARID1A", "ARIH2", "ARL2", "ARL3", "ARL6", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ASAH1", "ASCC1", "ASCC3", "ASNA1", "ASNS", "ATAD2", "ATG9A", "ATIC", "ATP11C", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0D1", "ATP6V1A", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "B3GALT6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCL2L13", "BCLAF1", "BCOR", "BCS1L", "BLVRA", "BLVRB", "BPTF", "BRD1", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "C1QBP", "CAB39", "CACNA2D1", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2G", "CAND1", "CAP1", "CAPN1", "CAPN2", "CAPZB", "CARM1", "CASK", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CCAR2", "CCDC124", "CCDC6", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC73", "CDH2", "CDIPT", "CDK1", "CDK2", "CDK4", "CDK5", "CDKAL1", "CDS2", "CEBPZ", "CELF1", "CENPF", "CEP170", "CEP44", "CEPT1", "CERS2", "CFL1", "CFL2", "CHAF1A", "CHAMP1", "CHD1", "CHD1L", "CHD4", "CHD7", "CHEK2", "CHKA", "CHMP5", "CHMP6", "CHORDC1", "CHTF18", "CIP2A", "CKB", "CLASP1", "CLIC1", "CLPTM1L", "CLTA", "CLTB", "CLTC", "CLUH", "CMPK1", "CNN2", "CNOT1", "CNOT9", "CNP", "COA3", "COLEC12", "COLGALT1", "COMT", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7B", "COPS8", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPT2", "CRKL", "CRTAP", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNND1", "CTPS1", "CTR9", "CTSA", "CTSB", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYB5B", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DARS", "DBNL", "DCAF1", "DCAF7", "DCTN1", "DCTN2", "DCTN4", "DCTPP1", "DDAH2", "DDB1", "DDOST", "DDX1", "DDX17", "DDX20", "DDX21", "DDX3X", "DDX5", "DDX52", "DDX56", "DEK", "DERL1", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX29", "DHX36", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DLAT", "DLD", "DLGAP5", "DLST", "DNAAF5", "DNAJA1", "DNAJB1", "DNAJB11", "DNAJC3", "DNAJC7", "DNAJC8", "DNM1L", "DNM2", "DNMT1", "DOCK1", "DPM1", "DPYSL2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "DYNLL2", "DYNLT1", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EFTUD2", "EHD1", "EHMT1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF4A1", "EIF4A2", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAVL1", "ELMOD2", "ELOB", "ELOC", "ELP3", "ELP4", "EMD", "EML4", "ENAH", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX1", "EPHX2", "EPRS", "EPS15", "EPS15L1", "ERCC2", "ERCC3", "ERCC4", "ERI1", "ESD", "ESS2", "ETF1", "ETFA", "ETFDH", "EWSR1", "EXO1", "EXOC5", "EXOC6", "EXOC7", "EXOSC2", "EXOSC7", "EXOSC9", "EZR", "F11R", "FAF1", "FAH", "FAM120A", "FANCD2", "FANCI", "FARSB", "FASN", "FAU", "FDFT1", "FDPS", "FECH", "FEN1", "FGFR1OP", "FH", "FKBP10", "FKBP1A", "FKBP2", "FKBP4", "FKBP5", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FNTA", "FOXRED1", "FSCN1", "FTO", "FUCA1", "FUS", "FXR1", "FXR2", "G3BP1", "G6PD", "GABARAPL2", "GALNT1", "GAMT", "GAPDH", "GART", "GBA", "GCC2", "GCDH", "GCLM", "GDAP1", "GDI1", "GFPT1", "GGCT", "GGCX", "GGH", "GIGYF2", "GLA", "GLB1", "GLRX", "GLS", "GLUD1", "GM2A", "GNA13", "GNAI2", "GNAI3", "GNG5", "GNPAT", "GNS", "GOT1", "GOT2", "GPD1L", "GPD2", "GPHN", "GPI", "GPS1", "GRB2", "GRSF1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GTF2I", "GTPBP4", "GUSB", "GYG1", "GYS1", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HADH", "HADHA", "HADHB", "HAT1", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HEBP1", "HELLS", "HEXA", "HEXB", "HEXIM1", "HGS", "HIBADH", "HIBCH", "HIRIP3", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HMBS", "HMGA1", "HMGA2", "HMGB1", "HMGB2", "HMGCR", "HMGCS1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPB11", "HSPD1", "HTT", "HUS1", "HYOU1", "IARS", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFNGR1", "IFT27", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP3", "ILF2", "IMP3", "IMPAD1", "IMPDH2", "IPO9", "IQGAP1", "IQGAP2", "IQSEC1", "IRF2BPL", "IRS4", "ITCH", "ITGB1", "ITPA", "IVD", "JUP", "KAT7", "KDM1A", "KDM1B", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHSRP", "KIF1B", "KIF22", "KIF23", "KIF2C", "KIF4A", "KIF5B", "KLC1", "KMT2A", "KPNA1", "KPNA4", "KPNB1", "KTN1", "LARP1", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LEMD3", "LGALS3", "LGALS3BP", "LIG3", "LIN28B", "LLGL1", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LPGAT1", "LRP1", "LRPPRC", "LRRC59", "LRSAM1", "LRWD1", "LSM2", "LSM4", "LSM7", "LSS", "LTA4H", "LZTFL1", "MACF1", "MAD2L1", "MAGT1", "MANF", "MAP1B", "MAP2K1", "MAP2K4", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC2", "MARCKS", "MARS", "MAT2A", "MAT2B", "MAU2", "MBD3", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDC1", "MDH1", "MDH2", "ME2", "MECP2", "MFAP1", "MFN2", "MGST3", "MIA3", "MIF", "MKI67", "MMADHC", "MOGS", "MORF4L1", "MOV10", "MPDU1", "MPG", "MPI", "MPP2", "MPST", "MRE11", "MRPL19", "MRPL40", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTMR6", "MTOR", "MTR", "MUT", "MYBBP1A", "MYCBP", "MYCBP2", "MYEF2", "MYH10", "MYH9", "MYL6", "MYL6B", "MYO1C", "MYO6", "NAA15", "NAA40", "NAA50", "NAE1", "NAGLU", "NAMPT", "NAP1L1", "NAPA", "NARS", "NAT10", "NCAPG", "NCBP1", "NCDN", "NCKAP1", "NCL", "NCSTN", "ND1", "NDUFA10", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV2", "NEDD4L", "NEFM", "NEK9", "NELFB", "NELFCD", "NELFE", "NF1", "NFATC2IP", "NIPBL", "NKRF", "NME1", "NONO", "NOP2", "NPC1", "NPC2", "NSDHL", "NSF", "NUDC", "NUDT21", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP214", "NUP62", "NUP88", "NUP98", "NXF1", "OAT", "OCRL", "OGDH", "OGT", "OPA1", "ORC2", "ORC3", "ORC5", "OXCT1", "P3H1", "P4HA1", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PAICS", "PAIP1", "PAK2", "PAPOLA", "PAPSS1", "PAPSS2", "PARK7", "PARN", "PARP1", "PBK", "PBRM1", "PC", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCM1", "PCNA", "PDCD4", "PDCD6", "PDCD6IP", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA6", "PDLIM5", "PDS5A", "PDS5B", "PEBP1", "PECR", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM3", "PGRMC2", "PHB", "PHB2", "PHF5A", "PHF6", "PHGDH", "PI4K2A", "PI4KA", "PIBF1", "PIGT", "PIK3C2A", "PIK3R4", "PKM", "PKN2", "PLCG1", "PLEC", "PLK1", "PLOD1", "PLOD2", "PMPCA", "PNP", "PNPT1", "PODXL", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "PON2", "POR", "PPAT", "PPIB", "PPID", "PPIF", "PPM1G", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4R3A", "PPP5C", "PPT2", "PRCC", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PRIM1", "PRIM2", "PRKAA1", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF3", "PRPF38A", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRRC2C", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSPC1", "PTBP1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PURA", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QKI", "QPRT", "RAB10", "RAB13", "RAB14", "RAB21", "RAB23", "RAB2A", "RAB3B", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RALA", "RAN", "RANBP1", "RANBP9", "RANGAP1", "RAPGEF2", "RARS", "RBM14", "RBM17", "RBM39", "RBM4", "RBM5", "RBMX", "RBPJ", "RCC1", "RCN1", "RDX", "RECQL", "REXO2", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOG", "RIF1", "RIPK1", "RNASEH2A", "RNASEH2B", "RNASET2", "RNF14", "RNF2", "RNF20", "RNF40", "RNMT", "RNPS1", "ROCK1", "RPA1", "RPA2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPRD1B", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RTCB", "RTN3", "RTN4", "RUVBL1", "S100A11", "SACM1L", "SAFB", "SAMHD1", "SAP18", "SAR1A", "SARS", "SCAF11", "SCAMP2", "SCARB1", "SCARB2", "SCD", "SCO1", "SCO2", "SCP2", "SCRIB", "SDHA", "SDHB", "SEC13", "SEC14L2", "SEC23A", "SEC23B", "SEC24A", "SEC24C", "SEC31A", "SELENBP1", "SEPT11", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETDB1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SFPQ", "SFSWAP", "SGPL1", "SH3GL1", "SH3GLB1", "SHMT2", "SIN3A", "SIRT1", "SIRT2", "SKP1", "SKP2", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC2A1", "SLC30A7", "SLC35B2", "SLC38A1", "SLC3A2", "SLC7A1", "SLC7A5", "SLIT2", "SLTM", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMYD3", "SNAP23", "SNAP29", "SND1", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SOD2", "SORT1", "SPEN", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRM", "SRP54", "SRPK1", "SRRM1", "SRSF1", "SRSF10", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "STAG1", "STAG2", "STAM", "STAT1", "STAT3", "STIP1", "STMN1", "STRAP", "STUB1", "STX4", "STXBP3", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUPT5H", "SUZ12", "SYNE2", "TAB1", "TAF5", "TALDO1", "TAOK1", "TARDBP", "TBC1D4", "TBCA", "TBK1", "TBL2", "TCF20", "TCP1", "TECR", "TELO2", "TERF2IP", "TFAM", "TFB1M", "TFRC", "THRAP3", "TIGAR", "TJP1", "TK1", "TKT", "TLN1", "TMED10", "TMEM43", "TMOD3", "TMPO", "TMPO", "TNPO1", "TOMM40", "TOMM70", "TOP1", "TOP2A", "TOPBP1", "TOR1AIP1", "TP53", "TP53BP1", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAP1", "TRAPPC11", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TRIP4", "TRMT2A", "TRRAP", "TSG101", "TSPO", "TSPYL1", "TTC19", "TTC21B", "TTC26", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TXNDC5", "TXNL4A", "TXNRD1", "TXNRD2", "TYMS", "U2AF2", "UBA1", "UBA3", "UBAP2L", "UBE2L3", "UBE3A", "UBR5", "UBTF", "UCHL5", "UFD1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119", "UNG", "UPF1", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "USMG5", "USP10", "USP5", "USP7", "USP8", "USP9X", "UTRN", "VAPA", "VAPB", "VARS1", "VBP1", "VCL", "VDAC1", "VDAC2", "VDAC3", "VIM", "VMP1", "VPS16", "VPS33A", "VPS4A", "WAPL", "WARS", "WDHD1", "WDR1", "WDR5", "WFS1", "WNK1", "XAB2", "XPNPEP3", "XPO1", "XPO5", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZC3H15", "ZFR", "ZFYVE16", "ZMPSTE24", "ZNF318", "ZYX"], "leading_proteins": ["AAMP", "ABCB1", "ACAT2", "ACOX3", "ACP6", "ACTN4", "AGL", "AGPAT1", "AHCYL1", "AIFM1", "AKAP8", "AKT2", "ALDH3A2", "AMOT", "ANAPC1", "ANAPC2", "ANAPC5", "ANAPC7", "ANXA1", "APLP2", "APPL1", "ARL2", "ATP6AP1", "ATP6V1E1", "BAIAP2", "CARM1", "CASK", "CBX1", "CDC16", "CDC23", "CDC27", "CDC37", "CDK1", "CDK2", "CDK4", "CDKAL1", "CERS2", "CHEK2", "CHKA", "CLPTM1L", "CLUH", "COLEC12", "COPS6", "CPNE1", "CPT2", "CRKL", "CRTAP", "CSNK1A1", "CTBP1", "CTNNB1", "CTSB", "CYFIP1", "CYP51A1", "DDX1", "DDX5", "DHCR24", "DHFR", "DIABLO", "ECE1", "ECI1", "EIF4B", "EIF5", "ELOC", "ELP3", "EMD", "EPHX1", "ERCC2", "F11R", "FASN", "FDFT1", "FKBP1A", "FLNA", "FMR1", "FOXRED1", "FUS", "GALNT1", "GBA", "GGH", "GLA", "GLB1", "GRB2", "GSTM3", "GSTO1", "GUSB", "GYS1", "HADH", "HDAC2", "HEXA", "HEXIM1", "HGS", "HLA-A", "HLA-B", "HLA-C", "HMOX1", "HNRNPD", "HNRNPF", "HNRNPH1", "HNRNPK", "HNRNPU", "HSP90AA1", "HSPB1", "ICMT", "IDH1", "IDH2", "IFNGR1", "IFT27", "KDM5A", "KDSR", "KHSRP", "KMT2A", "KPNA1", "LBR", "LGALS3BP", "LMAN1", "LMNB2", "LRP1", "LRWD1", "LSS", "LTA4H", "MAP2K1", "MAP2K4", "MAPK14", "MAPRE2", "MBD3", "MCL1", "MDC1", "MIF", "MPP2", "MRE11", "MSH2", "MSH6", "MSMO1", "MTHFD2", "MTOR", "MYCBP", "NAA40", "NAGLU", "NAMPT", "NCSTN", "NDUFB3", "NDUFS2", "NELFCD", "NPC1", "ORC2", "ORC3", "P3H1", "P4HA1", "PAIP1", "PBK", "PCK2", "PCM1", "PDCD4", "PDE6D", "PEBP1", "PECR", "PFDN4", "PFDN6", "PFN1", "PFN2", "PIBF1", "PIK3C2A", "PIK3R4", "PLK1", "PMPCA", "PON2", "PPAT", "PPP1CA", "PPP2R1A", "PPP2R1B", "PRCC", "PRKAA1", "PRKAR1A", "PRKCB", "PRKDC", "PRMT1", "PRMT5", "PSMA3", "PSMA6", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PTGES2", "PTGR1", "PTPN11", "RAD21", "RALA", "RBM4", "RBPJ", "REXO2", "RRM2", "RTN3", "RTN4", "SCARB1", "SCO1", "SCO2", "SDHB", "SEC13", "SEC23B", "SET", "SETD2", "SHMT2", "SIN3A", "SKP1", "SLC16A1", "SLC25A15", "SLC25A20", "SLC7A5", "SMARCD1", "SMARCE1", "SMC1A", "SMC3", "SPTLC2", "SQSTM1", "STAM", "STAT1", "SUZ12", "TAB1", "TAOK1", "TFRC", "TJP1", "TP53", "TPM1", "TTC19", "TUBB", "TUBB2B", "TUBB4B", "TYMS", "UBE3A", "UNC119", "UQCRFS1", "USP8", "VBP1", "VDAC1", "VDAC2", "VDAC3", "VIM", "WFS1", "YBX1", "YBX3", "ZMPSTE24"]} \ No newline at end of file diff --git a/opencell_localization/advanced/idx2term.json b/opencell_localization/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..e65f70bcb36e2eeacf75bf3d99d94d74daf114cb --- /dev/null +++ b/opencell_localization/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "nuclear_membrane"} \ No newline at end of file diff --git a/opencell_localization/advanced/plot_0.png b/opencell_localization/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..8f86807f2eea84d3b46b9f6717d7ca5347e7e49d --- /dev/null +++ b/opencell_localization/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:47b33040f663c56c58d91ecf90275651faf7ae928ae05a5a264a9b8d76d203ae +size 185600 diff --git 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sha256:7114f9e56f573e71314785cf1670791afbf03bf02ff3a34b3f74854e752b8d1f +size 63203 diff --git a/opencell_localization/df_merge.tsv b/opencell_localization/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..24fef4ca709e5b5485db59c75244618c247960da --- /dev/null +++ b/opencell_localization/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +nuclear_membrane 8 33 2.33786296705504 0.0193943579020994 8.679611650485437 30.93446601941747 -0.1292797107723345 0.6939536351161025 4.753565023401797 1.6570169876585483 0.6912151049720543 0.2897249869533181 0.0023728758072474 0.000895633126088 0.0061250241039257 0.0003104448575285 7.999759770652472e-05 diff --git a/opencell_localization/metrics.json b/opencell_localization/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..81a5800bac7da9e5a406da19b9075c7f82447b39 --- /dev/null +++ b/opencell_localization/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2812, + "annotations_size": 17, + "title": "Average number of proteins per term", + "value": 88.23529411764706 +} \ No newline at end of file diff --git a/opencell_localization/paths.json b/opencell_localization/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..f4f5cef813ea81e88be573bdd7e76ad7c62e5c47 --- /dev/null +++ b/opencell_localization/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/opencell_localization/fragment/C428/C428_val_log2fc"} \ No newline at end of file diff --git a/opencell_localization/result.tsv b/opencell_localization/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..9645a25a0c3a19bcb5766804f66f14150bad30a6 --- /dev/null +++ b/opencell_localization/result.tsv @@ -0,0 +1,6 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +nuclear_membrane 0.5391360424305882 2.33786296705504 0.0193943579020994 0.2831891158282287 0.2018200411027919 33 P55735,O00505,Q9H074,Q14739,O00629,P52294,O60684,P57740 8 +mitochondria 0.6801746206100351 1.8821658216252075 0.0598135046553125 0.6495402480878062 0.338943193046771 10 P21796 1 +big_aggregates 0.4067636227221291 1.2026947567431772 0.2290944636705929 0.9880044601359216 0.97365147060002 32 O00629,P52294,Q92696,O60684,Q7L7X3 5 +golgi 0.3429661906864809 0.941827332272501 0.3462810492016701 0.9992728093686772 0.981129639404732 60 P55735,Q5VW38,O14976,Q9Y487,Q15437,Q8IXU6,P36543 7 +focal_adhesions 0.3474411596422301 0.0589202407416069 0.95301563627687 1.0 1.0 5 Q6RW13 1 diff --git a/opencell_localization/selections.json b/opencell_localization/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..d17b90d15926d6739ee03fa104b6e60e306a71f5 --- /dev/null +++ b/opencell_localization/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["big_aggregates", "cell_contact", "centrosome", "chromatin", "cytoplasmic", "cytoskeleton", "er", "focal_adhesions", "golgi", "membrane", "mitochondria", "nuclear_membrane", "nuclear_punctae", "nucleolus_fc_dfc", "nucleolus_gc", "nucleoplasm", "vesicles"], "available_proteins": ["AAMP", "AATF", "ABCE1", "ACLY", "ACTN1", "ACTN4", "ACTR2", "AGTRAP", "AHCY", "AHSA1", "AKAP12", "AKAP8L", "AKR1A1", "AKT2", "ALDH9A1", "ANAPC16", "ANAPC2", "ANKRD17", "ANXA11", "AP2B1", "AP2S1", "APLP2", "APPL1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARHGAP1", "ARHGAP17", "ARHGEF7", "ARID1A", "ARL1", "ARL2", "ARL3", "ARL6", "ARL6IP1", "ARL6IP5", "ARL8A", "ARPC2", "ARPC3", "ATG9A", "ATP1A1", "ATP2B1", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATXN10", "ATXN2L", "BAG6", "BAIAP2", "BANF1", "BAZ1A", "BAZ1B", "BCAP31", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOP1", "BPNT1", "BRD2", "BTF3", "BUB1B", "BYSL", "C1orf123", "CAD", "CALD1", "CAMK2G", "CANX", "CAPRIN1", "CAPZB", "CBX1", "CCAR1", "CCDC22", "CCDC47", "CCDC86", "CCDC93", "CCNB1", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2BP2", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDS2", "CEP170", "CEPT1", "CHEK2", "CHMP2A", "CHMP2B", "CHMP4B", "CHMP6", "CHMP7", "CKAP2", "CKAP2L", "CKAP4", "CKAP5", "CKB", "CLASP1", "CLINT1", "CLNS1A", "CLPTM1", "CLTA", "CLTB", "CLTC", "CNN2", "COIL", "COMMD4", "COPA", "COPB2", "COPG1", "COPG2", "COPZ1", "CORO1C", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CTBP1", "CTBP2", "CTCF", "CTNNB1", "CTNNBL1", "CTPS1", "CTTN", "CYB5R3", "CYP51A1", "DAD1", "DBNL", "DCTN2", "DDB1", "DDOST", "DDX21", "DDX39B", "DDX47", "DDX5", "DDX56", "DDX6", "DHCR24", "DHX37", "DHX9", "DIAPH1", "DKC1", "DNAJA1", "DNAJA2", "DNAJB1", "DNAJC11", "DNAJC13", "DNAJC17", "DNAJC2", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DOCK7", "DRG1", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "DYNLL2", "EBNA1BP2", "EDC4", "EDF1", "EEA1", "EEF1G", "EFTUD2", "EIF2AK2", "EIF3B", "EIF3E", "EIF3G", "EIF3I", "EIF3K", "EIF3M", "EIF4A1", "EIF4A3", "EIF5", "EMC1", "EMC2", "EMC4", "EMC7", "EMG1", "ENO1", "EPS15", "ERG28", "ESD", "ESYT1", "EWSR1", "EZR", "FAM120A", "FASN", "FAU", "FBL", "FDPS", "FKBP5", "FKBP8", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAK", "GAPDH", "GAR1", "GBF1", "GDI1", "GDI2", "GET4", "GNL2", "GNL3", "GORASP2", "GPR107", "GRB2", "GSPT1", "GTF2F1", "GTPBP4", "GYG1", "GYS1", "H1F0", "HDAC1", "HDAC2", "HEATR3", "HGS", "HLA-A", "HMGA1", "HMGB2", "HMGCS1", "HMGN2", "HNRNPA0", "HNRNPC", "HNRNPD", "HNRNPH1", "HNRNPL", "HNRNPU", "HSP90AA1", "HSP90AB1", "HSPA12A", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPB1", "HSPB11", "HSPBP1", "HSPH1", "HUS1", "IDI1", "IGF1R", "IGF2BP1", "IGF2BP3", "ILF3", "IMP3", "INTS14", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", 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0.020655629069872 5.550970873786408 17.609223300970875 0.8395368249042097 0.3495065414698917 3.0409541216574527 2.8086572783837886 1.152491475155923 0.3107783941454108 0.2516826286650005 0.1868885334554594 0.0614247268920475 0.0180565405233996 0.0037452233271246 +primary active transporter 2 21 2.3074137121297182 0.021031767536169 8.614077669902912 23.45631067961165 1.2392440710771837 0.271771563990288 4.792195908457348 3.1431129799052804 1.4794913205770832 0.3014776193450941 0.0675138603248962 0.0369748680428621 0.1194965359594502 0.1881433143308717 0.5853384905806133 +transmembrane signal receptor 4 8 2.271079387012368 0.0231421725842968 3.266990291262136 7.169902912621359 1.6693846681257831 0.1085289610325799 1.5770125590990791 1.7927217985188668 1.0928815816574815 0.16461969248918 0.1314138992592091 0.3651094145888684 0.058599533767272 0.1818956974368412 0.4640895753399153 +oxygenase 2 6 2.0515171758172888 0.040216608724892 3.138349514563106 6.771844660194175 1.5409868347565758 0.1477866581414416 1.2914149665013366 1.041089559555361 1.2379399582807478 0.2357869798067575 0.0116325359304104 0.1114073342812727 0.0015052123544451 0.0193169154759243 0.0269295467729808 diff --git a/panther_protein_class/metrics.json b/panther_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..f3d76695e41668db1acbc60e13fc197d328b99db --- /dev/null +++ b/panther_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2812, + "annotations_size": 154, + "title": "Average number of proteins per term", + "value": 12.753246753246753 +} \ No newline at end of file diff --git a/panther_protein_class/paths.json b/panther_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..4a51eacc5bdbae4860b6039edfcd0a74f17f7f04 --- /dev/null +++ b/panther_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/panther_protein_class/fragment/C428/C428_val_log2fc"} \ No newline at end of file diff --git a/panther_protein_class/result.tsv b/panther_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..39ec0cc700eede6d5d21779c27d9b073118212b4 --- /dev/null +++ b/panther_protein_class/result.tsv @@ -0,0 +1,53 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +transporter 0.6062489293162849 3.652284654614221 0.0002599175367936 0.0392417893274805 0.0200136503331121 56 P55735,O00505,P53985,Q9HD45,Q99595,O60830,O00629,P52294,Q8NFH4,O43772,Q9Y619,Q567V2,O60684,P57740,Q9H2D1 15 +protease 0.6019006047606027 2.918981850397372 0.0035117666944968 0.4182787529367021 0.1352030177381276 36 P25788,P28074,Q99436,P20618,P28072,P28070,O75976,P49721,P60900 9 +acyltransferase 0.6780728531145651 2.314220517500506 0.020655629069872 0.9598156969374868 0.3563894577981715 15 Q8NF37,P49356,Q92696,Q8NCC3,Q99943,Q9BWD1 6 +primary active transporter 0.6095449616518857 2.3074137121297182 0.021031767536169 0.9621239856937918 0.3563894577981715 21 O60888,Q9NS69 2 +transmembrane signal receptor 0.8087962372828175 2.2710793870123673 0.0231421725842968 0.9728337582202612 0.3563894577981715 8 Q8WUJ1,O15173,P15260,Q9UMX5 4 +oxygenase 0.8218141004361512 2.0515171758172888 0.040216608724892 0.998202464513558 0.3877185824740896 6 Q16850,P30519 2 +protease inhibitor 0.7543373385620693 1.9336348117172992 0.0531580439727652 0.9997778051099352 0.3877185824740896 7 P30086 1 +protein modifying enzyme 0.5379446614220574 1.902206361600555 0.0571441814885234 0.9998839690176708 0.3877185824740896 22 P50897,O60725,Q86X55,Q92791,P13674,Q9UMR5 6 +translation factor 0.7454862370898387 1.893924398432017 0.0582350454746793 0.9999029157273605 0.3877185824740896 7 P51116,P51114,Q06787 3 +metalloprotease 0.4962524037888466 1.8610842405573316 0.0627322813594597 0.9999535480943412 0.3877185824740896 25 P55786,Q9NZ08,Q10713,P42892,Q6P179,Q9NQH7,Q9UIQ6,O75844,Q5JRX3,Q9BYT8 10 +G-protein coupled receptor 0.9750889679715296 1.8527802640509752 0.063913860128145 0.9999617496425276 0.3877185824740896 2 Q9NPR9 1 +serine protease 0.5886602343456526 1.838846931770353 0.0659377031172594 0.9999725918507192 0.3877185824740896 16 P10619,O14773,Q9HB40,P42785 4 +cysteine protease 0.5037238434480036 1.8251616800420096 0.0679766345896131 0.9999804238533768 0.3877185824740896 24 Q96FW1,Q8TEY7,Q92820,Q96K76,Q9UPU5,P07858 6 +voltage-gated ion channel 0.922971515807679 1.7479807724590295 0.0804673569020169 0.9999975490114756 0.4273094125141586 4 P21796 1 +mitochondrial carrier protein 0.7353804025291425 1.6821732541346852 0.0925352488379609 0.9999996795326748 0.4516124113430768 6 Q70HW3 1 +viral or transposable element protein 0.9288256227758018 1.663706870751263 0.0961710225632339 0.9999998273032368 0.4516124113430768 2 Q9H2J4 1 +histone modifying enzyme 0.6130222609001515 1.6538265267833987 0.0981627645317357 0.9999998770475876 0.4516124113430768 11 Q9NWY4,Q9BYW2,P29375,Q03164 4 +major histocompatibility complex protein 0.8871082621082568 1.6122517880371663 0.1069071599367319 0.9999999725793608 0.4703915037216206 4 P55899,P01889,P04439 3 +galactosidase 0.9391242435030256 1.450909152593116 0.1468051589675849 0.9999999999759328 0.5079948306383419 3 P16278,Q8IW92 2 +phospholipase 0.6451590475549509 1.433416955744639 0.151738715645219 0.9999999999901472 0.5079948306383419 7 Q8IV08,Q8NHP8 2 +apolipoprotein 0.8661921708185127 1.4061489684255366 0.1596798940195145 0.9999999999976852 0.5232064612554307 2 Q9BQE5 1 +scaffold/adaptor protein 0.3718252743511659 1.3102693550531934 0.1901047305963965 0.999999999999992 0.5387251064066916 67 Q9UKG1,Q8WYP5,Q9UQB8,Q9UBB6,Q9Y5X3,Q5BKZ1,O43823,Q96CX2,P46109,Q92783,Q14168,Q9UNH7,Q9NZW5,Q9Y679,Q7L576,P07602,Q8N3C0,Q9ULX6,P35613,O14936 20 +tubulin 0.8063443746058448 1.3035067198458916 0.1924018237166755 0.9999999999999948 0.5387251064066916 4 Q9BVA1,P07437 2 +nucleic acid metabolism protein 0.6979898617173674 1.2612105833328675 0.2072329865954931 0.9999999999999996 0.5674414178000713 5 Q8IWR0 1 +methyltransferase 0.5254713955146295 1.1762418845459974 0.2394982315921803 1.0 0.6147121277532628 11 P34897,Q14353,P21964,Q9H2P9,Q8N6R0,Q9BV86 6 +DNA glycosylase 0.7950177935943068 1.1148188144100817 0.2649280723061464 1.0 0.6398199518525193 2 P13051 1 +glycosidase 0.7564921274375163 1.112555920334451 0.2658992007698781 1.0 0.6398199518525193 4 Q9BTY2,P06865 2 +protein-binding activity modulator 0.6513902647965798 1.0681593352281795 0.2854486444576427 1.0 0.6582457332308145 5 O14737,O14530,Q13625 3 +membrane trafficking regulatory protein 0.484754442681735 1.0660973505302334 0.2863796371848348 1.0 0.6582457332308145 13 Q8WTV0 1 +transferase 0.3928527054391786 1.0440556358510336 0.2964596498069682 1.0 0.671393912798134 27 Q96IJ6,P43490,P30419,O43505 4 +calmodulin-related 0.5271358890629705 1.0024644371795994 0.316119334158913 1.0 0.69864268650513 9 Q14257,P80303 2 +esterase 0.5811635773689902 0.9994745586794188 0.3175648575023317 1.0 0.69864268650513 6 Q9NUJ1 1 +secondary carrier transporter 0.4895274093862291 0.978257772706251 0.3279468492709825 1.0 0.7113213350384691 11 Q96ES6,Q9UBX3 2 +chaperone 0.3429447108722909 0.9409064624216936 0.3467527955950285 1.0 0.7292380126570109 58 O75937,Q5TC12,Q16543,O60884,P78318,Q9Y2R0,P46379,O15260,Q8N183,Q9UBS4,P62942,P30533,P49321,Q99543,P61758,P30414 16 +kinase 0.4335503267939068 0.845624475249084 0.3977622673429828 1.0 0.761468030726179 15 Q9NVE7,Q9HA64,P35790 3 +reductase 0.3658597826707186 0.840706450918104 0.4005124057715616 1.0 0.761468030726179 31 O95881,Q14739,Q14914,Q15392,Q06136,Q9BY49,Q9H7Z7 7 +oxidoreductase 0.3475784806835843 0.7308863420268646 0.4648485790728986 1.0 0.7866668261233669 38 O43676,O75306,Q9Y6M9,Q8N4Q0,O43169 5 +lyase 0.4677580780650472 0.7059290570926143 0.4802322564777301 1.0 0.8013193590830255 9 Q9UHG3 1 +ATP synthase 0.3843432260129986 0.6834534046753338 0.4943203838499184 1.0 0.8013193590830255 20 Q9Y487,O75964,Q93050 3 +hydrolase 0.3676415033578069 0.6148494120854829 0.5386541738575552 1.0 0.829527427740635 21 P07099 1 +oxidase 0.4029059840209434 0.5973243933663216 0.5502908213593964 1.0 0.8390572919737331 13 Q8NB78 1 +calcium-binding protein 0.4481152811367704 0.5219084417124175 0.601734080403064 1.0 0.8769182235009171 7 P50995,P04083 2 +membrane traffic protein 0.2961601507798485 0.4246568650956148 0.6710868327412487 1.0 0.8769182235009171 59 A6NIH7,P11717,Q13432,O14976,Q99523,Q8IUD2,Q96D71,Q96PC5,P43307,O43493,Q9Y2T2,Q9H223 12 +transcription cofactor 0.3507426989129668 0.2694254541068338 0.7876023005701187 1.0 0.934747941528224 11 O00625,Q13363,Q9HCD5,Q99417 4 +peroxidase 0.416815105094402 0.2086076259797126 0.8347545568817467 1.0 0.9606367242455728 5 P32119,Q8TED1,P30048,Q13162 4 +phosphatase modulator 0.3530040351589843 0.1265800944312382 0.8992727525383775 1.0 1.0 6 P30153,P30154 2 +translation initiation factor 0.2729119301205007 0.1152457746292944 0.908250317449186 1.0 1.0 41 O75153 1 +mRNA polyadenylation factor 0.3211922263063773 0.0755135288459497 0.9398061338081848 1.0 1.0 7 P51003 1 +C2H2 zinc finger transcription factor 0.3935185185185215 0.0503518904402271 0.959841973587258 1.0 1.0 4 P49711,Q9Y467,O95785 3 +endodeoxyribonuclease 0.3809184763261014 0.0137905248465534 0.9889971018932536 1.0 1.0 3 P52926,Q92889 2 +replication origin binding protein 0.3770118240688618 0.0124155116980337 0.9900941093927956 1.0 1.0 3 Q9UBD5 1 +kinase inhibitor 0.3527945888216461 0.0056778021527153 0.995469793663442 1.0 1.0 3 Q9NQG5,Q96P16 2 diff --git a/panther_protein_class/selections.json b/panther_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..a757713b757293d735fd8c25dffa2bca7537e3db --- /dev/null +++ b/panther_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthase", "ATP-binding cassette (ABC) transporter", "C2H2 zinc finger transcription factor", "DNA glycosylase", "DNA helicase", "DNA ligase", "DNA metabolism protein", "DNA methyltransferase", "DNA polymerase processivity factor", "DNA topoisomerase", "DNA-binding transcription factor", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "G-protein", "G-protein coupled receptor", "G-protein modulator", "GTPase-activating protein", "Hsp90 family chaperone", "P53-like transcription factor", "RNA helicase", "RNA metabolism protein", "RNA methyltransferase", "RNA processing factor", "RNA splicing factor", "SNARE protein", "acetyltransferase", "actin and actin related protein", "actin binding motor protein", "actin or actin-binding cytoskeletal protein", "acyltransferase", "aldolase", "amino acid kinase", "amino acid transporter", "aminoacyl-tRNA synthetase", "apolipoprotein", "aspartic protease", "basic leucine zipper transcription factor", "cadherin", "calcium-binding protein", "calmodulin-related", "carbohydrate kinase", "cell adhesion molecule", "cell junction protein", "centromere DNA-binding protein", "chaperone", "chaperonin", "chromatin/chromatin-binding, or -regulatory protein", "cyclase", "cysteine protease", "cytokine", "cytoskeletal protein", "damaged DNA-binding protein", "deaminase", "decarboxylase", "defense/immunity protein", "dehydratase", "dehydrogenase", "endodeoxyribonuclease", "endoribonuclease", "epimerase/racemase", "esterase", "exodeoxyribonuclease", "exoribonuclease", "extracellular matrix glycoprotein", "extracellular matrix protein", "extracellular matrix structural protein", "galactosidase", "general transcription factor", "glucosidase", "glycosidase", "glycosyltransferase", "growth factor", "guanyl-nucleotide exchange factor", "heterotrimeric G-protein", "histone", "histone modifying enzyme", "homeodomain transcription factor", "hydratase", "hydrolase", "integrin", "intercellular signal molecule", "intermediate filament binding protein", "ion channel", "isomerase", "kinase", "kinase activator", "kinase inhibitor", "kinase modulator", "ligase", "lyase", "mRNA capping factor", "mRNA polyadenylation factor", "major histocompatibility complex protein", "membrane traffic protein", "membrane trafficking regulatory protein", "metalloprotease", "methyltransferase", "microtubule binding motor protein", "microtubule or microtubule-binding cytoskeletal protein", "mitochondrial carrier protein", "mutase", "non-motor actin binding protein", "non-motor microtubule binding protein", "non-receptor serine/threonine protein kinase", "nucleic acid metabolism protein", "nucleotide kinase", "nucleotide phosphatase", "nucleotidyltransferase", "oxidase", "oxidoreductase", "oxygenase", "peptide hormone", "peroxidase", "phosphatase", "phosphatase activator", "phosphatase modulator", "phosphodiesterase", "phospholipase", "primary active transporter", "primase", "protease", "protease inhibitor", "protein modifying enzyme", "protein phosphatase", "protein-binding activity modulator", "pyrophosphatase", "reductase", "replication origin binding protein", "ribosomal protein", "scaffold/adaptor protein", "secondary carrier transporter", "serine protease", "small GTPase", "structural protein", "tight junction", "transaminase", "transcription cofactor", "transfer/carrier protein", "transferase", "transketolase", "translation elongation factor", "translation factor", "translation initiation factor", "translation release factor", "translational protein", "transmembrane signal receptor", "transporter", "tubulin", "tyrosine protein kinase receptor", "ubiquitin-protein ligase", "vesicle coat protein", "viral or transposable element protein", "voltage-gated ion channel", "zinc finger transcription factor"], "available_proteins": ["AACS", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ACAA2", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADPGK", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGPAT1", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK6", "AKAP1", "AKAP12", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG5", "ALKBH5", "ALYREF", "AMPD2", "ANAPC1", "ANAPC7", "ANKFY1", "ANKHD1", "ANKRD17", "ANLN", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APLP2", "APOBEC3C", "APOL2", "APPL1", "APRT", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP1", "ARHGDIA", "ARHGEF7", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL6", "ARL6IP5", "ARPC1A", "ARPC3", "ARPC4", "ASAH1", "ASCC3", "ASNA1", "ASNS", "ASPH", "ATAD2", "ATAD5", "ATP11C", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN2L", "AUP1", "B3GALT6", "B4GAT1", "BAG6", "BAIAP2", "BCAP31", "BCAS2", "BCLAF1", "BDH2", "BLMH", "BLVRA", "BLVRB", "BOP1", "BPNT1", "BRD1", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BZW1", "BZW2", "CACNA2D1", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASK", "CAST", "CBFB", "CBR1", "CBX8", "CCAR1", "CCAR2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2BP2", "CD47", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDKN2AIP", "CDS2", "CEBPZ", "CEP170", "CEPT1", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHEK2", "CHERP", "CHKA", "CHMP2A", "CHMP2B", "CHMP4B", "CHMP5", "CHMP6", "CHMP7", "CHORDC1", "CHTF18", "CHTOP", "CKAP2", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLIC1", "CLIC4", "CLNS1A", "CLPB", "CLPP", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT7", "CNP", "COA3", "COG4", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX7A2", "COX7C", "CPD", "CPOX", "CPSF1", "CPSF3", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSE1L", "CSNK1A1", "CSNK2B", "CSRP2", "CSTB", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNND1", "CTPS1", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC22", "CYB5B", "CYB5D2", "CYB5R3", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DBR1", "DBT", "DCAF13", "DCAKD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDOST", "DEK", "DENR", "DERL1", "DERL2", "DHCR24", "DHCR7", "DHFR", "DHRS13", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX34", "DHX35", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLGAP5", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC17", "DNAJC2", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK1", "DOCK7", "DOHH", "DPH5", "DPM1", "DPP3", "DPYSL2", "DSG2", "DSP", "DSTN", "DTYMK", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "DYNLL2", "DYNLT1", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC4", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMOD2", "ELOB", "ELOC", "ELP1", "ELP3", "EMC2", "EMG1", "ENAH", "ENO1", "ENO2", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERH", "ERI1", "ERMP1", "ERO1A", "ERP29", "ESD", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC5", "EXOC6", "EXOC7", "EXOSC1", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "FAHD1", "FAM98A", "FAM98B", "FARSA", "FARSB", "FBL", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FKBP1A", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FLAD1", "FLII", "FMR1", "FN3KRP", "FNDC3A", "FNTA", "FNTB", "FOXRED1", "FRG1", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GATAD2A", "GATAD2B", "GATB", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLM", "GCN1", "GDI1", "GDI2", "GDPD1", "GFPT1", "GGH", "GINS2", "GLA", "GLB1", "GLB1L2", "GLDC", "GLMN", "GLO1", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNG5", "GNPAT", "GNPDA1", "GNS", "GOT1", "GOT2", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPR107", "GPR108", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GTF2F1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADHB", "HAT1", "HBS1L", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HECTD1", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HM13", "HMBS", "HMGA1", "HMGA2", "HMGCR", "HMGN2", "HMOX1", "HMOX2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HP1BP3", "HPF1", "HPRT1", "HS2ST1", "HSD17B10", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HTATSF1", "HUS1", "HUWE1", "IARS", "IARS2", "ICE1", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFNGR1", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQSEC1", "IRF2BPL", "ISOC1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "ITPK1", "IVD", "JMJD6", "KARS", "KAT7", "KCTD12", "KDM1A", "KDM1B", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0368", "KIF11", "KIF14", "KIF18A", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KLC1", "KMT2A", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "KYAT3", "LAMP1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LBR", "LCLAT1", "LDHA", "LDHB", "LENG8", "LETM1", "LGALS3", "LIG3", "LIMA1", "LIN28B", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LRP1", "LRPAP1", "LRRC40", "LRRC47", "LRRC59", "LRWD1", "LSM14A", "LSM2", "LSM4", "LSM6", "LSM7", "LSM8", "LSS", "LYAR", "LYPLA1", "LZTFL1", "M6PR", "MACF1", "MAGED2", "MAGT1", "MANBA", "MAP1B", "MAP2K1", "MAP2K4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARS", "MAT2A", "MAT2B", "MBOAT7", "MCCC1", "MCCC2", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "ME2", "MECP2", "MED24", "MED4", "METTL13", "METTL16", "MFAP1", "MFSD3", "MFSD5", "MGAT1", "MGEA5", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MIPEP", "MKRN2", "MMS19", "MOB4", "MOGS", "MORF4L1", "MORF4L2", "MPG", "MPHOSPH10", "MPI", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17L2", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL45", "MRPL47", "MRPL51", "MRPL53", "MRPL9", "MRPS11", "MRPS15", "MRPS17", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTHFS", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MUT", "MYBBP1A", "MYCBP", "MYCBP2", "MYDGF", "MYEF2", "MYG1", "MYL6", "MYL6B", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA35", "NAA50", "NAE1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NASP", "NAT10", "NAXE", "NCAPD2", "NCAPD3", "NCBP1", "NCDN", "NCOA5", "ND1", "NDRG3", "NDUFA10", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA9", "NDUFAF2", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV2", "NECAP2", "NEDD4L", "NENF", "NF1", "NHP2", "NIP7", "NIPBL", "NIT2", "NKRF", "NKTR", "NLN", "NME1", "NMT1", "NNT", "NOC4L", "NOL6", "NOL9", "NOM1", "NONO", "NOP14", "NOP56", "NOP58", "NOP9", "NOVA2", "NPEPPS", "NPM1", "NRDC", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUMA1", "NUP107", "NUP153", "NUP155", "NUP160", "NUP210", "NUP214", "NUP37", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "NXN", "OAT", "OCIAD1", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC2", "ORC3", "ORC5", "OSGEP", "OTUB1", "OXA1L", "OXCT1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPN1", "PACSIN2", "PACSIN3", "PAFAH1B3", "PAIP1", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PARN", "PARP1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PCYOX1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PDZD11", "PEBP1", "PECR", "PEPD", "PES1", "PEX14", "PEX19", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHC2", "PHF3", "PHF6", "PHGDH", "PI4K2A", "PI4KA", "PICALM", "PIK3C2A", "PIK3R4", "PIR", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLD1", "POLD2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "POP7", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL4", "PPM1F", "PPM1G", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA1", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2C", "PRSS3", "PRTFDC1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD7", "PSMD8", "PSMG1", "PSPC1", "PTCD1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PUDP", "PUF60", "PUM1", "PURA", "PWP1", "PWWP2A", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "QARS", "QKI", "QSOX2", "RAB3GAP1", "RAB3GAP2", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RAD23B", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAPGEF2", "RARS", "RAVER1", "RBBP6", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM26", "RBM34", "RBM4", "RBPJ", "RCL1", "RCN1", "RCN2", "RDH11", "RDH13", "RDX", "RECQL", "REEP5", "REPS1", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOG", "RHOT1", "RHOT2", "RIDA", "RIF1", "RIPK1", "RNASEH2A", "RNF14", "RNF2", "RNMT", "RNPS1", "ROCK1", "RPA1", "RPF1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RRM1", "RRM2", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RSU1", "RTN4IP1", "S100A11", "SACM1L", "SAE1", "SALL2", "SAMHD1", "SAP18", "SAP30BP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF4", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCYL2", "SDE2", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC13", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SELENBP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SHMT2", "SIGMAR1", "SIN3A", "SKIV2L", "SKIV2L2", "SKP1", "SLC12A2", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC35B2", "SLC38A1", "SLC7A1", "SLC7A5", "SLC9A6", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC6", "SMN1*", "SMNDC1", "SMPD4", "SMYD3", "SNAP23", "SNAP29", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SNX27", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SORT1", "SPAG9", "SPCS2", "SPCS3", "SPEN", "SPR", "SPTLC1", "SPTLC2", "SQLE", "SREK1", "SRFBP1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "STAG1", "STAG2", "STAM", "STAT1", "STAT3", "STOML2", "STRAP", "STRBP", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUN1", "SUN2", "SUPT16H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SWAP70", "SYNCRIP", "SYNGR2", "TAB1", "TAF15", "TAF2", "TAF6L", "TAGLN2", "TALDO1", "TAOK1", "TARS", "TARS2", "TBC1D10B", "TBC1D15", "TBC1D4", "TBC1D8B", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBK1", "TBL3", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TCP1", "TECR", "TERF2IP", "TES", "TFB1M", "TFG", "TFIP11", "TFRC", "TGOLN2", "THOC1", "THOC2", "THOC3", "THOP1", "THRAP3", "TIA1", "TIAL1", "TIGAR", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TJP1", "TK1", "TKT", "TM9SF2", "TM9SF3", "TM9SF4", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM115", "TMEM259", "TMOD3", "TMPO", "TMX2", "TNPO1", "TNPO3", "TOMM20", "TOMM22", "TOMM40", "TOMM5", 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sha256:e6cb02f04c2701bcfed71bd659844ac29506f750fad4d51e3b6f81ea0c0d16f2 +size 133981 diff --git a/pharos_dto/consensus.joblib b/pharos_dto/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..0db7687b5a90ffa11ca23cc895e1d6c5857d005e --- /dev/null +++ b/pharos_dto/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:9287c03a6f818002b987ee8cb7f9f9675b5f77b89ef51d3f2322db988283828a +size 326549 diff --git a/pharos_dto/df_merge.tsv b/pharos_dto/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..8e29334cb70168f2c0f0de9e4d2f7404b82a2d4b --- /dev/null +++ b/pharos_dto/df_merge.tsv @@ -0,0 +1,9 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Receptor 6 24 2.9990021014966475 0.0027086543845282 8.25242718446602 27.344660194174757 1.739519175745715 0.1905542238199536 2.855648283399814 4.245230977176689 1.1861053756197322 0.2707159726336181 0.0059819326350983 0.0017602267192959 0.0034901493178882 0.0140990291270638 0.0328461598740068 +Protease 24 105 2.7761423616882626 0.0055008116479964 23.87864077669903 112.97330097087378 0.5565894930811873 0.44121745363286 8.615285022365173 8.917462185063522 1.4311973593718734 0.3778605174872721 0.0006617004349027 0.0119845399878974 0.0003656061160771 0.0004762066439326 0.0005678959384318 +SLC25 family of mitochondrial transporters 5 19 2.715462998856286 0.0066183171553393 9.148058252427184 20.71359223300971 2.0411027534642088 0.1411881998864352 5.368907349966936 1.8276489510009888 1.309103123363054 0.2428184236965967 0.0265109458224097 0.1665759675679584 0.0052800410185589 0.0002303056568621 0.0081853110588452 +Mitochondrial nucleotide transporter subfamily 1 8 2.0645341377857966 0.0389671006154861 4.216019417475728 9.065533980582524 1.5870110662923598 0.1668197633609344 2.720728714423222 1.1029864386277723 1.1616247375257451 0.2431804664231326 0.0046050017435412 0.0711332726649859 0.0088504827764808 0.0495157384890535 0.1630814235328921 +Signaling 5 17 2.0495844214163745 0.0404050019257324 5.66747572815534 18.009708737864077 1.330299096012152 0.2668377480945127 2.507969905227609 1.6994867622232877 1.0107551340834326 0.2926688105318188 0.1222384639831224 0.3523884632837075 0.0526082110144703 0.0613062198602933 0.1348927714123106 +Acyltransferase 3 8 2.003058459036645 0.0451710141151813 3.1067961165048543 9.41504854368932 0.3809422525127639 0.5105103319247358 1.8677779818542355 1.784525377484509 0.9351567129762406 0.3147395520597634 0.1925534392463908 0.141543756104335 0.2590666885683055 0.0379489226270714 0.0612536211646263 +Reductase 4 17 2.0017341104463453 0.0453133357335013 4.563106796116505 16.313106796116504 1.2016212969729014 0.3130807121312539 1.9089462498224232 1.180966799206311 0.8349037556988175 0.2876306629725971 0.0167389364845026 0.1330370821365251 0.031373049189738 0.0005802452812718 0.0023211498250519 +Protease inhibitor 1 7 1.9691733628293129 0.048933186615379 3.021844660194174 10.191747572815531 0.0156913070142034 0.5225114188512615 1.89070503497177 2.0561604935207436 0.9786766316122176 0.2972879918724294 0.2968690190702732 0.2222355866483168 0.3896854720293997 0.3495520980441666 0.716114393880072 diff --git a/pharos_dto/metrics.json b/pharos_dto/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..c8e099e25cc588dd61110865222349bbdd7b88e5 --- /dev/null +++ b/pharos_dto/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2812, + "annotations_size": 1848, + "title": "Average number of proteins per term", + "value": 3.1222943722943723 +} \ No newline at end of file diff --git a/pharos_dto/paths.json b/pharos_dto/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..0d05057eb70b0fff63ce511c548ec403fb00da2a --- /dev/null +++ b/pharos_dto/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_dto/fragment/C428/C428_val_log2fc"} \ No newline at end of file diff --git a/pharos_dto/result.tsv b/pharos_dto/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..4bc590d4e9e8d862c2f5e666b1b80cfcd8efd992 --- /dev/null +++ b/pharos_dto/result.tsv @@ -0,0 +1,68 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Receptor 0.6693264569447358 2.9990021014966475 0.0027086543845282 0.9933449863786152 0.0629475727086028 24 A6NIH7,Q8WTV0,P15260,Q14108,Q9UQB8,Q567V2 6 +Protease 0.4458442174118187 2.7761423616882626 0.0055008116479964 0.9999625896118076 0.0629475727086028 105 Q96FW1,Q5BJF2,P42785,Q6P179,Q9UIQ6,Q5JRX3,P07858,Q9HB40,Q8TEY7,Q92945,O75844,Q8NHP8,Q8TCT9,P10619,Q92820,P61978,P42892,Q96K76,O14773,Q66K14,P17812,Q96I24,Q9BYT8,Q96RU2 24 +SLC25 family of mitochondrial transporters 0.7013351530970566 2.715462998856286 0.0066183171553393 0.9999953157405872 0.063114255250574 19 Q70HW3,O43772,Q9Y619,Q9UBX3,Q9H2D1 5 +Mitochondrial nucleotide transporter subfamily 0.7630641791471153 2.0645341377857966 0.0389671006154861 1.0 0.1228698486752549 8 Q70HW3 1 +Signaling 0.6145887403245603 2.0495844214163745 0.0404050019257324 1.0 0.1250727697801568 17 Q07820,Q96PC5,P43490,Q8WUJ1,O15173 5 +Acyltransferase 0.7496551993814502 2.003058459036645 0.0451710141151813 1.0 0.1343021843237724 8 P49356,Q9Y679,Q92696 3 +Reductase 0.6067809923594327 2.0017341104463453 0.0453133357335013 1.0 0.1344125913892625 17 Q15392,O95881,Q14739,Q9H7Z7 4 +Protease inhibitor 0.7622896045315742 1.9691733628293129 0.048933186615379 1.0 0.1399822428254186 7 P30086 1 +SLC superfamily of solute carriers 0.4744946380581475 1.8882606161773956 0.0589909717454864 1.0 0.1548513008319018 38 Q70HW3,Q9Y6C9,O43772,Q9Y619,Q8IXU6,P53985,Q9UBX3,Q9H2D1 8 +V-type ATPase 0.7070924221419383 1.8052501511177677 0.0710355463136565 1.0 0.1729561127636854 8 Q9Y487,Q93050,P21283,P61421 4 +Serine protease 0.4799834277861945 1.7521661400728008 0.0797452440570543 1.0 0.1864266194355292 27 P10619,O14773,Q9HB40,P42785,Q92945 5 +Cysteine protease 0.4570255194671462 1.732378461412226 0.083206200308781 1.0 0.1897950988743048 38 Q8NHP8,Q96FW1,Q8TEY7,Q66K14,Q92820,P17812,Q96K76,P07858 8 +Translation factor 0.4806059326062379 1.649838711686918 0.0989759287313973 1.0 0.2099971484450314 24 O75153,P55010,Q14671,P23588,Q9Y262 5 +STE group 0.7681502026548361 1.5507520921403977 0.1209611055452577 1.0 0.2398456255875926 5 P45985,Q7L7X3 2 +Esterase 0.6272147516455973 1.5072562774670688 0.1317449800079122 1.0 0.2542324742813327 9 P50897,Q9UMR5 2 +Writer 0.6125702978976318 1.434009744943932 0.1515694819568258 1.0 0.277877383587514 9 Q9BYW2,O96028,Q9H7B4,Q86X55 4 +STE7 family 0.8708185053380786 1.4251865488084143 0.1541032835480646 1.0 0.2808709222679181 2 P45985 1 +Epigenetic regulator 0.4373963635337681 1.4169875612660492 0.1564865642152457 1.0 0.2835168339899747 28 Q99873,Q16637,Q92769,Q8IXJ6,Q8NB78,O96028,P83916,Q9H7B4,Q86X55,Q9BYW2 10 +SLC35 family of nucleotide sugar transporters 0.861921708185065 1.3885794848100408 0.1649606592667198 1.0 0.2939703937559289 2 Q8IXU6 1 +Protein methyltransferase 0.618314731519307 1.3810294954109097 0.1672698918358697 1.0 0.2965543275955921 8 Q9BYW2,O96028,Q9H7B4,Q86X55 4 +Translation initiation factor 0.5004314354563668 1.3748590879335132 0.1691751351323029 1.0 0.2986372279959323 18 P55010,Q9Y262,O75153 3 +Methyltransferase 0.574760706253183 1.338994475638751 0.1805724713459535 1.0 0.3124512425536724 10 P34897,P21964,Q08J23,Q9H2P9,Q9BV86 5 +Tubulin 0.8063443746058448 1.3035067198458916 0.1924018237166755 1.0 0.3250078338468158 4 Q9BVA1,P07437 2 +SET domain 0.8679245283018848 1.1899138884573683 0.23408023914698 1.0 0.3717116935790911 3 Q9BYW2,O96028 2 +Metalloprotease 0.3988936168021998 1.180621906384549 0.2377529571752297 1.0 0.3748869154094065 35 P52888,P55786,Q9NZ08,Q10713,P42892,Q6P179,O75844,Q9UIQ6,Q5JRX3,Q9BYT8 10 +Aspartic protease 0.8578551249570038 1.1531686095153664 0.2488411850860206 1.0 0.3874123926191795 3 Q5BJF2 1 +Tudor domain 0.8017793594306029 1.1422725907505964 0.2533407306250836 1.0 0.3917771298704222 2 Q16637 1 +Methyl-lysine/arginine binding protein 0.6114649568168791 1.1343708524351137 0.256639020192198 1.0 0.3932578020855571 6 P83916,Q16637 2 +Transporter 0.3526955326964553 1.0976826165713156 0.2723431030479739 1.0 0.4082981466115594 168 P55735,Q9HD45,Q70HW3,Q96ES6,O43493,P53985,P57740,Q9BQE5,O00505,Q92973,Q9Y487,O00629,P52294,Q93050,Q8IXU6,O60684,Q9UBX3,Q9H2D1,O43772,Q9P2W9,Q9Y619,P08183,Q8NFH4,Q9Y6C9,Q92572,P17900,Q7L0J3 27 +Calcium-binding protein 0.4720051584942432 1.0818182336935405 0.2793333028896265 1.0 0.4149581541318567 15 Q14257,O43852,P60660,P14649,P80303,P43307 6 +Mitochondrial amino acid transporter subfamily 0.735171576667341 1.0313525926751732 0.3023755036219222 1.0 0.4382666123084802 4 O43772 1 +Galactosidase 0.820377155469853 1.0172924596803614 0.3090143225771675 1.0 0.4433683758715881 3 Q8IW92 1 +Protein arginine methyltransferase 0.7288745758232646 1.0074654158567469 0.3137111691878633 1.0 0.4476743171113292 4 Q99873,Q86X55 2 +Oxidoreductase 0.3212464364596896 0.9580225752952848 0.3380513749785241 1.0 0.4692881613940428 110 O95881,Q14739,Q96CU9,Q16850,P21912,Q15392,Q14914,O15260,O75306,P00374,Q15800,Q9BY49,Q9Y6M9,Q8N4Q0,Q9H7Z7,O43169 16 +Extracellular matrix glycoprotein 0.7065773600208329 0.923357947431128 0.3558206989193966 1.0 0.483853312437855 4 Q32P28 1 +Unclassified protein 0.4502547112510787 0.8653366502325655 0.3868540403616229 1.0 0.5128452414550067 13 Q9NVE7,Q9HA64 2 +Phospholipase 0.6889172049138355 0.8574102302716539 0.3912182074217614 1.0 0.5156713604246898 4 Q8NCC3 1 +Lipase 0.6889172049138355 0.8574102302716539 0.3912182074217614 1.0 0.5156713604246898 4 Q8NCC3 1 +Calmodulin 0.4576125350082343 0.8525163644026523 0.3939275603009071 1.0 0.5177653850896703 12 Q14257,O43852,P60660,P14649,P80303 5 +Intracellular calcium-sensing protein 0.4576125350082343 0.8525163644026523 0.3939275603009071 1.0 0.5177653850896703 12 Q14257,O43852,P60660,P14649,P80303 5 +PIKK family 0.7156583629893198 0.800542365288957 0.4233966280594503 1.0 0.540730455185808 2 P42345 1 +Extracellular structure 0.4841197654396021 0.7866225042130355 0.4315028814929511 1.0 0.5480724380579297 9 Q32P28,Q92791,Q9Y2T2 3 +Enzyme modulator 0.2998122971605823 0.7268525450521229 0.4673162903347527 1.0 0.572160002134849 100 Q15369,P30086,Q01105,Q9NTK5,Q16543,Q99733,Q06481,P46379,Q96D71,Q15437,O14737,P55209,P39687 13 +Phosphatase inhibitor 0.475294420674783 0.6411896257086634 0.5213994890607281 1.0 0.6119421993917534 7 Q01105,Q99733,P55209 3 +CAMKL family 0.6640569395017772 0.6096740508616607 0.5420777473082425 1.0 0.627275940529513 2 Q13131 1 +Protein phosphatase 0.4328491228925318 0.5996034768349588 0.5487705294799972 1.0 0.6318554133825761 10 P62136,P30153,P10586,P30154 4 +Phosphatase modulator 0.4453392259893009 0.5974925234333326 0.5501785972216062 1.0 0.6326773122180468 9 Q01105,Q99733,P55209 3 +Eraser 0.4541061188514996 0.5477698532847437 0.583849941022277 1.0 0.6507567497039614 7 Q8NB78,Q92769 2 +SLC3 and SLC7 families of heteromeric amino acid transporters (HATs) 0.6645419866141284 0.4915699486395142 0.6230233919888906 1.0 0.6754936471343792 3 Q01650 1 +Atypical group 0.6443574225703145 0.4321519513537193 0.665630978482868 1.0 0.7003519310494831 3 P78527,P42345 2 +F-type and V-type ATPases 0.3568271240103282 0.4009283586598932 0.6884728702713867 1.0 0.7171915807562134 15 Q9Y487 1 +Dehydrogenase 0.2873840339951572 0.3160631593400955 0.7519545690356495 1.0 0.7728654302435375 53 Q96CU9,Q14914,O75306,Q9BY49,Q8N4Q0 5 +Ca2+-ATPases 0.5683274021352241 0.3093738918385945 0.7570371281820751 1.0 0.7763621603110293 2 P16615 1 +CK2 family 0.5462633451957223 0.2540469110061427 0.7994593168843875 1.0 0.8180513940212337 2 P19784 1 +Peroxidase 0.416815105094402 0.2086076259797126 0.8347545568817467 1.0 0.8522797906726343 5 P32119,Q8TED1,P30048,Q13162 4 +Chromodomain 0.4660169050900209 0.1676877059631376 0.8668289684535757 1.0 0.8825894951527317 4 P83916,P45973 2 +Zinc finger transcription factor 0.3478260869565159 0.1136323731752056 0.9095292234738648 1.0 0.923521980758078 6 O95785,Q7Z3K3,P49711,Q9Y467,Q8WU90 5 +Hydrolase 0.2513047838105963 0.1040137254921242 0.9171584562858964 1.0 0.9307571813379112 96 P16278,Q9NRW3,Q8N2A8,P50897,Q9Y217,Q969T7,O43865,Q5TFE4,O43924,Q9NPH0,P10253,P11117,Q8NCC3,P06865,Q9UMR5,Q96C86,Q8IW92,P30154 18 +mRNA splicing factor 0.2580527543713211 0.0514622563289014 0.9589571770647668 1.0 0.9714063347148152 61 Q01844,P38159,P35637,Q13242,P62995,Q14011,P98179,Q96PK6,Q9BWF3,O75525,Q07666,Q92804 12 +Histone deacetylase 0.3938569753390493 0.0507465656251088 0.959527470422626 1.0 0.9714063347148152 4 Q92769 1 +C2H2 zinc finger transcription factor 0.3935185185185215 0.0503518904402271 0.959841973587258 1.0 0.9714063347148152 4 P49711,Q9Y467,O95785 3 +Antibacterial response protein 0.3761565836298975 0.0353264458939185 0.9718194357141487 1.0 0.9829897740556908 2 Q9NUQ3 1 +CDK1 subfamily 0.3626334519572949 0.0307086622091975 0.975501882977824 1.0 0.9850969834661306 2 P24941 1 +Immune response 0.3036350677120372 0.0228819446501687 0.9817444427074828 1.0 0.9908594921482404 6 P78318,Q6P2E9,Q9NUQ3,P40222,Q9NX40 5 +KRAB box transcription factor 0.3933784264862966 0.0187939465866352 0.9850054828954656 1.0 0.9936081508683516 3 P49711,O95785 2 +Kinase inhibitor 0.3529202279202248 0.0124756556882322 0.9900461251479432 1.0 0.9971084000860416 4 Q9NQG5,Q96P16,Q5VZL5 3 +Replication origin binding protein 0.3770118240688618 0.0124155116980337 0.9900941093927956 1.0 0.9971084000860416 3 Q9UBD5 1 diff --git a/pharos_dto/selections.json b/pharos_dto/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..efff57181bbc023617360ff4c8917594858a9c51 --- /dev/null +++ b/pharos_dto/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase", "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1", "10 kDa heat shock protein, mitochondrial", "116 kDa U5 small nuclear ribonucleoprotein component", "14-3-3 protein beta/alpha", "14-3-3 protein epsilon", "14-3-3 protein eta", "14-3-3 protein gamma", "14-3-3 protein theta", "14-3-3 protein zeta/delta", "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "2',5'-phosphodiesterase 12", "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial", "2-hydroxyacyl-CoA lyase 1", "26S proteasome non-ATPase regulatory subunit 1", "26S proteasome non-ATPase regulatory subunit 12", "26S proteasome non-ATPase regulatory subunit 13", "26S proteasome non-ATPase regulatory subunit 14", "26S proteasome non-ATPase regulatory subunit 2", "26S proteasome non-ATPase regulatory subunit 3", "26S proteasome non-ATPase regulatory subunit 7", "26S proteasome non-ATPase regulatory subunit 8", "26S proteasome regulatory subunit 10B", "26S proteasome regulatory subunit 4", "26S proteasome regulatory subunit 6A", "26S proteasome regulatory subunit 6B", "26S proteasome regulatory subunit 7", "26S proteasome regulatory subunit 8", "28S ribosomal protein S11, mitochondrial", "28S ribosomal protein S2, mitochondrial", "28S ribosomal protein S27, mitochondrial", "28S ribosomal protein S29, mitochondrial", "28S ribosomal protein S35, mitochondrial", "28S ribosomal protein S5, mitochondrial", "28S ribosomal protein S7, mitochondrial", "3'(2'),5'-bisphosphate nucleotidase 1", "3'-5' exoribonuclease 1", "3-hydroxyacyl-CoA dehydrogenase type-2", "3-hydroxyisobutyrate dehydrogenase, mitochondrial", "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial", "3-ketoacyl-CoA thiolase, mitochondrial", "3-mercaptopyruvate sulfurtransferase", "39S ribosomal protein L1, mitochondrial", "39S ribosomal protein L11, mitochondrial", "39S ribosomal protein L12, mitochondrial", "39S ribosomal protein L13, mitochondrial", "39S ribosomal protein L14, mitochondrial", "39S ribosomal protein L17, mitochondrial", "39S ribosomal protein L19, mitochondrial", "39S ribosomal protein L2, mitochondrial", "39S ribosomal protein L20, mitochondrial", "39S ribosomal protein L21, mitochondrial", "39S ribosomal protein L24, mitochondrial", "39S ribosomal protein L38, mitochondrial", "39S ribosomal protein L39, mitochondrial", "39S ribosomal protein L41, mitochondrial", "39S ribosomal protein L43, mitochondrial", "39S ribosomal protein L44, mitochondrial", "39S ribosomal protein L47, mitochondrial", "39S ribosomal protein L51, mitochondrial", "39S ribosomal protein L9, mitochondrial", "4-trimethylaminobutyraldehyde dehydrogenase", "40S ribosomal protein S10", "40S ribosomal protein S11", "40S ribosomal protein S12", "40S ribosomal protein S13", "40S ribosomal protein S14", "40S ribosomal protein S15", "40S ribosomal protein S15a", "40S ribosomal protein S17", "40S ribosomal protein S18", "40S ribosomal protein S19", "40S ribosomal protein S2", "40S ribosomal protein S20", "40S ribosomal protein S23", "40S ribosomal protein S24", "40S ribosomal protein S26", "40S ribosomal protein S28", "40S ribosomal protein S3", "40S ribosomal protein S3a", "40S ribosomal protein S4, X isoform", "40S ribosomal protein S5", "40S ribosomal protein S6", "40S ribosomal protein S7", "40S ribosomal protein S8", "40S ribosomal protein S9", "40S ribosomal protein SA", "4F2 cell-surface antigen heavy chain", "5'-AMP-activated protein kinase catalytic subunit alpha-1", "5'-AMP-activated protein kinase subunit gamma-1", "5'-nucleotidase domain-containing protein 1", "5'-nucleotidase domain-containing protein 2", "5-formyltetrahydrofolate cyclo-ligase", "6-phosphogluconate dehydrogenase, decarboxylating", "6-phosphogluconolactonase", "60 kDa SS-A/Ro ribonucleoprotein", "60S ribosomal protein L10", "60S ribosomal protein L10a", "60S ribosomal protein L11", "60S ribosomal protein L12", "60S ribosomal protein L13", "60S ribosomal protein L13a", "60S ribosomal protein L14", "60S ribosomal protein L15", "60S ribosomal protein L18", "60S ribosomal protein L19", "60S ribosomal protein L21", "60S ribosomal protein L22", "60S ribosomal protein L23", "60S ribosomal protein L23a", "60S ribosomal protein L24", "60S ribosomal protein L26", "60S ribosomal protein L27", "60S ribosomal protein L27a", "60S ribosomal protein L28", "60S ribosomal protein L29", "60S ribosomal protein L3", "60S ribosomal protein L30", "60S ribosomal protein L31", "60S ribosomal protein L32", "60S ribosomal protein L35", "60S ribosomal protein L35a", "60S ribosomal protein L36", "60S ribosomal protein L36a", "60S ribosomal protein L37", "60S ribosomal protein L38", "60S ribosomal protein L5", "60S ribosomal protein L6", "60S ribosomal protein L7", "60S ribosomal protein L7-like 1", "60S ribosomal protein L7a", "60S ribosomal protein L8", "60S ribosomal protein L9", "7,8-dihydro-8-oxoguanine triphosphatase", "7-dehydrocholesterol reductase", "7-methylguanosine phosphate-specific 5'-nucleotidase", "A-kinase anchor protein 1, mitochondrial", "ABCB subfamily", "ABCC subfamily", "ABCD subfamily of peroxisomal ABC transporters", "ADP-dependent glucokinase", "ADP-ribose pyrophosphatase, mitochondrial", "ADP-sugar pyrophosphatase", "ADP/ATP translocase 1", "ADP/ATP translocase 2", "ADP/ATP translocase 3", "AFG3-like protein 2", "AGC group", "AH receptor-interacting protein", "AK1 subfamily", "AK2 subfamily", "AK3 subfamily", "AKT family", "AMP deaminase 2", "AMPK subfamily", "AP-1 complex subunit beta-1", "AP-1 complex subunit gamma-1", "AP-1 complex subunit mu-1", "AP-2 complex subunit alpha-1", "AP-2 complex subunit alpha-2", "AP-2 complex subunit beta", "AP-2 complex subunit mu", "AP-2 complex subunit sigma", "AP-3 complex subunit beta-1", "AP-3 complex subunit delta-1", "AP-3 complex subunit mu-1", "AP-3 complex subunit sigma-1", "AT-rich interactive domain-containing protein 3B", "ATP synthase F(0) complex subunit B1, mitochondrial", "ATP synthase mitochondrial F1 complex assembly factor 1", "ATP synthase subunit alpha, mitochondrial", "ATP synthase subunit beta, mitochondrial", "ATP synthase subunit d, mitochondrial", "ATP synthase subunit e, mitochondrial", "ATP synthase subunit f, mitochondrial", "ATP synthase subunit gamma, mitochondrial", "ATP-binding cassette sub-family B member 7, mitochondrial", "ATP-binding cassette sub-family D member 3", "ATP-binding cassette sub-family F member 1", "ATP-binding cassette sub-family F member 2", "ATP-binding cassette sub-family F member 3", "ATP-binding cassette transporter family", "ATP-citrate synthase", "ATP-dependent 6-phosphofructokinase, muscle type", "ATP-dependent 6-phosphofructokinase, platelet type", "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial", "ATP-dependent DNA helicase Q1", "ATP-dependent PFK group I subfamily", "ATP-dependent RNA helicase A", "ATP-dependent RNA helicase DHX29", "ATP-dependent RNA helicase DHX8", "ATP-dependent zinc metalloprotease YME1L1", "ATPase ASNA1", "ATPase family AAA domain-containing protein 2", "ATPase family AAA domain-containing protein 3A", "ATPase family AAA domain-containing protein 3B", "ATPase inhibitor, mitochondrial", "Acetoacetyl-CoA synthetase", "Acetolactate synthase-like protein", "Acetyl-CoA acetyltransferase, cytosolic", "Acetyl-CoA acetyltransferase, mitochondrial", "Acetyltransferase", "Acid ceramidase", "Acidic leucine-rich nuclear phosphoprotein 32 family member A", "Acidic leucine-rich nuclear phosphoprotein 32 family member B", "Acidic leucine-rich nuclear phosphoprotein 32 family member E", "Aconitate hydratase, mitochondrial", "Actin and actin related protein", "Actin binding motor protein", "Actin family cytoskeletal protein", "Actin-like protein 6A", "Actin-related protein 10", "Actin-related protein 2", "Actin-related protein 2/3 complex subunit 1A", "Actin-related protein 2/3 complex subunit 3", "Actin-related protein 2/3 complex subunit 4", "Actin-related protein 3", "Activating signal cointegrator 1", "Acyl-CoA dehydrogenase family member 11", "Acyl-CoA dehydrogenase family member 9, mitochondrial", "Acyl-CoA synthetase family member 3, mitochondrial", "Acyl-CoA-binding domain-containing protein 5", "Acyl-coenzyme A thioesterase 8", "Acyl-coenzyme A thioesterase 9, mitochondrial", "Acylamino-acid-releasing enzyme", "Acylpyruvase FAHD1, mitochondrial", "Acyltransferase", "Adenosine 3'-phospho 5'-phosphosulfate transporter 1", "Adenosine kinase", "Adenosylhomocysteinase", "Adenylate kinase 2, mitochondrial", "Adenylate kinase family", "Adenylate kinase isoenzyme 1", "Adenylate kinase isoenzyme 6", "Adenylosuccinate lyase", "Adenylosuccinate synthetase isozyme 2", "Adenylyl cyclase-associated protein 1", "Afadin", "Aflatoxin B1 aldehyde reductase member 2", "Alanine--tRNA ligase, cytoplasmic", "Alanine--tRNA ligase, mitochondrial", "Alanine/serine/cysteine transporter subfamily", "Alanyl-tRNA editing protein Aarsd1", "Alcohol dehydrogenase [NADP(+)]", "Alcohol dehydrogenase class-3", "Aldehyde dehydrogenase X, mitochondrial", "Aldehyde dehydrogenase, mitochondrial", "Aldose 1-epimerase", "Aldose reductase", "Alpha-adducin", "Alpha-aminoadipic semialdehyde dehydrogenase", "Alpha-centractin", "Alpha-enolase", "Alpha-soluble NSF attachment protein", "Alpha-taxilin", "Amidophosphoribosyltransferase", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1", "Aminoacyl-tRNA synthetase", "Amyloid-like protein 2", "Anaphase-promoting complex subunit 1", "Ancient ubiquitous protein 1", "Anion channel tweety (tweety) family", "Annexin", "Anoctamin-6", "Antibacterial response protein", "Apolipoprotein", "Apolipoprotein L2", "Apoptosis-inducing factor 1, mitochondrial", "Apoptosis-stimulating of p53 protein 2", "Arfaptin-1", "Arfaptin-2", "Arginase-2, mitochondrial", "Asparagine synthetase [glutamine-hydrolyzing]", "Asparagine--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, cytoplasmic", "Aspartate--tRNA ligase, mitochondrial", "Aspartic protease", "Ataxin-2-like protein", "Atp-dependent 6-phosphofructokinase, liver type", "Atypical SLC22B subfamily", "Atypical group", "B-cell receptor-associated protein 31", "BTB/POZ domain-containing protein KCTD12", "BUB family", "BUB3-interacting and GLEBS motif-containing protein ZNF207", "Basic leucine zipper and W2 domain-containing protein 1", "Basic leucine zipper and W2 domain-containing protein 2", "Bcl-2-associated transcription factor 1", "Beta-galactosidase", "Beta-galactosidase-1-like protein 2", "Beta-hexosaminidase subunit alpha", "Beta-hexosaminidase subunit beta", "Beta-mannosidase", "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1", "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2", "Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6", "Bifunctional epoxide hydrolase 2", "Bifunctional glutamate/proline--tRNA ligase", "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial", "Bifunctional purine biosynthesis protein PURH", "Biliverdin reductase A", "Biotin--protein ligase", "Bleomycin hydrolase", "Brain-specific angiogenesis inhibitor 1-associated protein 2", "Bromodomain", "Bromodomain-containing protein 2", "C-1-tetrahydrofolate synthase, cytoplasmic", "C-Jun-amino-terminal kinase-interacting protein 4", "C-terminal-binding protein 1", "C-terminal-binding protein 2", "C2H2 zinc finger transcription factor", "CAAX prenyl protease 1 homolog", "CAD protein", "CAMK group", "CAMK2 family", "CAMKL family", "CASK family", "CCAAT/enhancer-binding protein zeta", "CCK4 family", "CCR4-NOT transcription complex subunit 1", "CCR4-NOT transcription complex subunit 7", "CD2 antigen cytoplasmic tail-binding protein 2", "CDK family", "CDK1 subfamily", "CDK4 subfamily", "CDK5 subfamily", "CDKN2A-interacting protein", "CK1 family", "CK1 group", "CK2 family", "CLIP-associating protein 1", "CMGC group", "COP9 signalosome complex subunit 3", "COP9 signalosome complex subunit 5", "COP9 signalosome complex subunit 6", "COP9 signalosome complex subunit 8", "CRK7 subfamily", "CSK family", "CTP synthase 1", "Ca2+-ATPases", "Cadherin", "Calcium channel auxiliary subunit 2 types 1-4 (cca-2) family", "Calcium homeostasis endoplasmic reticulum protein", "Calcium uptake protein 1, mitochondrial", "Calcium uptake protein 2, mitochondrial", "Calcium-binding mitochondrial carrier protein Aralar1", "Calcium-binding mitochondrial carrier protein Aralar2", "Calcium-binding mitochondrial carrier protein SCaMC-1", "Calcium-binding protein", "Calcium-binding protein 39", "Calcium-dependent chloride channel (ca-clc) family", "Calcium/calmodulin-dependent protein kinase type ii subunit gamma", "Calcyclin-binding protein", "Calmodulin", "Calnexin", "Calpain-1 catalytic subunit", "Calpain-2 catalytic subunit", "Calponin-2", "Calponin-3", "Calreticulin", "Calumenin", "Camp-dependent protein kinase catalytic subunit alpha", "Cancer-related nucleoside-triphosphatase", "Caprin-1", "Carbohydrate kinase", "Carnitine O-palmitoyltransferase 2, mitochondrial", "Cartilage-associated protein", "Casein kinase II subunit alpha'", "Casein kinase i isoform alpha", "Casein kinase ii subunit beta", "Catechol O-methyltransferase", "Catenin alpha-1", "Catenin delta-1", "Cathepsin B", "Cation-dependent mannose-6-phosphate receptor", "Cation-independent mannose-6-phosphate receptor", "Cell adhesion", "Cell cycle and apoptosis regulator protein 2", "Cell division control protein 42 homolog", "Cell division cycle and apoptosis regulator protein 1", "Cell-cell junction", "Cellular structure", "Cellular tumor antigen p53", "Centromere/kinetochore protein zw10 homolog", "Centrosomal protein of 170 kDa", "Chaperone", "Chaperonin", "Charged multivesicular body protein 4b", "Charged multivesicular body protein 5", "Charged multivesicular body protein 6", "Charged multivesicular body protein 7", "Chitobiosyldiphosphodolichol beta-mannosyltransferase", "Chloride channel family", "Chloride intracellular channel protein 1", "Chloride intracellular channel protein 4", "Choline kinase alpha", "Choline/ethanolamine kinase family", "Choline/ethanolaminephosphotransferase 1", "Chromatin assembly factor 1 subunit A", "Chromatin assembly factor 1 subunit B", "Chromatin target of PRMT1 protein", "Chromatin/chromatin-binding protein", "Chromobox protein homolog 1", "Chromobox protein homolog 3", "Chromobox protein homolog 5", "Chromodomain", "Chromosome-associated kinesin KIF4A", "Cilia- and flagella-associated protein 20", "Citrate synthase, mitochondrial", "ClC-3/CLCN3 subfamily", "Class I transporters", "Clathrin heavy chain 1", "Clathrin light chain A", "Clathrin light chain B", "Cleavage and polyadenylation specificity factor subunit 1", "Cleavage and polyadenylation specificity factor subunit 3", "Cleavage and polyadenylation specificity factor subunit 5", "Cleavage and polyadenylation specificity factor subunit 7", "Cleavage stimulation factor subunit 3", "Cleft lip and palate transmembrane protein 1", "Cleft lip and palate transmembrane protein 1-like protein", "Clustered mitochondria protein homolog", "Coactosin-like protein", "Coatomer subunit alpha", "Coatomer subunit beta", "Coatomer subunit beta'", "Coatomer subunit delta", "Coatomer subunit gamma-1", "Coatomer subunit gamma-2", "Coatomer subunit zeta-1", "Cohesin subunit SA-1", "Cohesin subunit SA-2", "Coilin", "Cold-inducible RNA-binding protein", "Collectin-12", "Condensin complex subunit 1", "Condensin-2 complex subunit D3", "Core histone macro-H2A.1", "Core histone macro-H2A.2", "Coronin-1C", "Creatine kinase B-type", "Creatine kinase U-type, mitochondrial", "Crooked neck-like protein 1", "Cullin-1", "Cullin-2", "Cullin-4B", "Cullin-5", "Cullin-associated NEDD8-dissociated protein 1", "Cyclase", "Cyclin-dependent kinase 1", "Cyclin-dependent kinase 11b", "Cyclin-dependent kinase 12", "Cyclin-dependent kinase 13", "Cyclin-dependent kinase 2", "Cyclin-dependent kinase 4", "Cyclin-dependent-like kinase 5", "Cyclin-g-associated kinase", "Cystatin-B", "Cysteine and glycine-rich protein 2", "Cysteine and histidine-rich domain-containing protein 1", "Cysteine protease", "Cysteine protease inhibitor", "Cysteine--tRNA ligase, cytoplasmic", "Cytochrome b-c1 complex subunit 1, mitochondrial", "Cytochrome b-c1 complex subunit 2, mitochondrial", "Cytochrome b-c1 complex subunit 7", "Cytochrome b-c1 complex subunit 9", "Cytochrome b5 type B", "Cytochrome c oxidase subunit 2", "Cytochrome c oxidase subunit 5A, mitochondrial", "Cytochrome c oxidase subunit 5B, mitochondrial", "Cytochrome c oxidase subunit 7A2, mitochondrial", "Cytochrome c oxidase subunit 7C, mitochondrial", "Cytochrome c oxidase subunit NDUFA4", "Cytokine", "Cytokine receptor", "Cytoplasmic FMR1-interacting protein 1", "Cytoplasmic aconitate hydratase", "Cytoplasmic dynein 1 heavy chain 1", "Cytoplasmic dynein 1 light intermediate chain 1", "Cytoplasmic dynein 1 light intermediate chain 2", "Cytoskeleton-associated protein 5", "Cytosol aminopeptidase", "Cytosolic acyl coenzyme A thioester hydrolase", "Cytosolic non-specific dipeptidase", "Cytosolic purine 5'-nucleotidase", "D-3-phosphoglycerate dehydrogenase", "DDB1- and CUL4-associated factor 13", "DMPK family", "DNA (cytosine-5)-methyltransferase 1", "DNA binding protein", "DNA dC->dU-editing enzyme APOBEC-3C", "DNA damage-binding protein 1", "DNA glycosylase", "DNA helicase", "DNA ligase", "DNA ligase 3", "DNA methyltransferase", "DNA mismatch repair protein Msh2", "DNA mismatch repair protein Msh3", "DNA mismatch repair protein Msh6", "DNA polymerase delta subunit 2", "DNA polymerase epsilon subunit 4", "DNA polymerase processivity factor", "DNA primase small subunit", "DNA repair endonuclease XPF", "DNA replication complex GINS protein PSF2", "DNA replication licensing factor MCM2", "DNA replication licensing factor MCM3", "DNA replication licensing factor MCM4", "DNA replication licensing factor MCM5", "DNA replication licensing factor MCM6", "DNA replication licensing factor MCM7", "DNA topoisomerase", "DNA topoisomerase 1", "DNA-3-methyladenine glycosylase", "DNA-directed DNA polymerase", "DNA-directed RNA polymerase", "DNA-directed RNA polymerase I subunit RPA1", "DNA-directed RNA polymerase I subunit RPA2", "DNA-directed RNA polymerase II subunit RPB1", "DNA-directed RNA polymerase II subunit RPB2", "DNA-directed RNA polymerase II subunit RPB3", "DNA-directed RNA polymerase II subunit RPB4", "DNA-directed RNA polymerase II subunit RPB7", "DNA-directed RNA polymerase III subunit RPC1", "DNA-directed RNA polymerase III subunit RPC2", "DNA-directed RNA polymerase III subunit RPC3", "DNA-directed RNA polymerase, mitochondrial", "DNA-directed RNA polymerases I and III subunit RPAC1", "DNA-directed RNA polymerases I, II, and III subunit RPABC1", "DNA-directed RNA polymerases I, II, and III subunit RPABC3", "DNAPK subfamily", "DYRK family", "Damaged DNA-binding protein", "Deacetylase", "Deaminase", "Death-inducer obliterator 1", "Decarboxylase", "Dedicator of cytokinesis protein 7", "Dehydratase", "Dehydrogenase", "Delta(24)-sterol reductase", "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial", "Delta-1-pyrroline-5-carboxylate synthase", "Density-regulated protein", "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial", "Derlin-1", "Derlin-2", "Desmoglein-2", "Desmoplakin", "Digestive organ expansion factor homolog", "Dihydrofolate reductase", "Dihydrolipoyl dehydrogenase, mitochondrial", "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "Dihydropyrimidinase-related protein 2", "Dipeptidyl peptidase 1", "Dipeptidyl peptidase 3", "Diphthine methyl ester synthase", "Disks large-associated protein 5", "Dna-dependent protein kinase catalytic subunit", "Dolichol-phosphate mannosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A", "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B", "Double-stranded RNA-specific adenosine deaminase", "Drebrin", "Drebrin-like protein", "Dual specificity mitogen-activated protein kinase kinase 1", "Dual specificity mitogen-activated protein kinase kinase 4", "Dynactin subunit 1", "Dynactin subunit 2", "Dynamin-1-like protein", "Dynamin-2", "Dynamin-like 120 kDa protein, mitochondrial", "Dynein light chain 1, cytoplasmic", "Dynein light chain 2, cytoplasmic", "Dynein light chain Tctex-type 1", "E3 SUMO-protein ligase RanBP2", "E3 ubiquitin-protein ligase ARIH1", "E3 ubiquitin-protein ligase ARIH2", "E3 ubiquitin-protein ligase HUWE1", "E3 ubiquitin-protein ligase Itchy homolog", "E3 ubiquitin-protein ligase NEDD4-like", "E3 ubiquitin-protein ligase RBBP6", "E3 ubiquitin-protein ligase RNF14", "EH domain-containing protein 1", "EH domain-containing protein 4", "ELKS/Rab6-interacting/CAST family member 1", "ELMO domain-containing protein 2", "ER membrane protein complex subunit 2", "ERK subfamily", "ERO1-like protein alpha", "Early endosome antigen 1", "Electron transfer flavoprotein subunit alpha, mitochondrial", "Electron transfer flavoprotein subunit beta", "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial", "Elongation factor 1-alpha 2", "Elongation factor 1-beta", "Elongation factor 1-delta", "Elongation factor 2", "Elongation factor Ts, mitochondrial", "Elongation factor Tu, mitochondrial", "Elongation factor-like GTPase 1", "Elongator complex protein 1", "Elongator complex protein 3", "Elongin-B", "Elongin-C", "Endodeoxyribonuclease", "Endoplasmic reticulum aminopeptidase 1", "Endoplasmic reticulum aminopeptidase 2", "Endoplasmic reticulum metallopeptidase 1", "Endoplasmic reticulum protein SC65", "Endoplasmic reticulum resident protein 29", "Endoplasmin", "Endoribonuclease", "Endothelin-converting enzyme 1", "Enhancer of mRNA-decapping protein 4", "Enhancer of rudimentary homolog", "Enoyl-CoA delta isomerase 1, mitochondrial", "Enoyl-CoA delta isomerase 2, mitochondrial", "Enoyl-CoA hydratase, mitochondrial", "Enzyme", "Enzyme modulator", "Epidermal growth factor receptor substrate 15", "Epidermal growth factor receptor substrate 15-like 1", "Epigenetic regulator", "Epimerase family protein SDR39U1", "Epimerase/racemase", "Epiplakin", "Eraser", "Esterase", "Ethylmalonyl-CoA decarboxylase", "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A", "Eukaryotic peptide chain release factor subunit 1", "Eukaryotic translation initiation factor 2 subunit 1", "Eukaryotic translation initiation factor 2 subunit 2", "Eukaryotic translation initiation factor 2A", "Eukaryotic translation initiation factor 3 subunit A", "Eukaryotic translation initiation factor 3 subunit B", "Eukaryotic translation initiation factor 3 subunit D", "Eukaryotic translation initiation factor 3 subunit E", "Eukaryotic translation initiation factor 3 subunit F", "Eukaryotic translation initiation factor 3 subunit H", "Eukaryotic translation initiation factor 3 subunit I", "Eukaryotic translation initiation factor 3 subunit J", "Eukaryotic translation initiation factor 3 subunit L", "Eukaryotic translation initiation factor 4 gamma 1", "Eukaryotic translation initiation factor 4 gamma 2", "Eukaryotic translation initiation factor 4 gamma 3", "Eukaryotic translation initiation factor 4B", "Eukaryotic translation initiation factor 4H", "Eukaryotic translation initiation factor 5", "Eukaryotic translation initiation factor 5A-1", "Eukaryotic translation initiation factor 5B", "Exocyst complex component 5", "Exocyst complex component 6", "Exocyst complex component 7", "Exodeoxyribonuclease", "Exonuclease 1", "Exoribonuclease", "Exosome complex component CSL4", "Exosome complex component MTR3", "Exosome complex component RRP4", "Exosome complex component RRP40", "Exosome complex component RRP42", "Exosome complex component RRP43", "Exosome complex component RRP45", "Exosome complex component RRP46", "Exosome complex exonuclease RRP44", "Exportin-1", "Exportin-2", "Exportin-4", "Exportin-5", "Exportin-7", "Exportin-T", "Extracellular matrix glycoprotein", "Extracellular matrix structural protein", "Extracellular structure", "Ezrin", "F-actin-capping protein subunit alpha-1", "F-actin-capping protein subunit alpha-2", "F-actin-capping protein subunit beta", "F-type ATPase", "F-type and V-type ATPases", "FACT complex subunit SPT16", "FAD-dependent oxidoreductase domain-containing protein 1", "FRAP subfamily", "Far upstream element-binding protein 1", "Far upstream element-binding protein 2", "Far upstream element-binding protein 3", "Farnesyl pyrophosphate synthase", "Fascin", "Fatty acid synthase", "Ferrochelatase, mitochondrial", "Flap endonuclease 1", "Flavin reductase (NADPH)", "Fragile X mental retardation syndrome-related protein 1", "Fragile X mental retardation syndrome-related protein 2", "Fumarate hydratase, mitochondrial", "G patch domain-containing protein 4", "G-protein", "G-protein coupled receptor", "G-protein modulator", "G-rich sequence factor 1", "G2/mitotic-specific cyclin-B1", "G2/mitotic-specific cyclin-B2", "GC-rich sequence DNA-binding factor 2", "GDP-L-fucose synthase", "GDP-mannose 4,6 dehydratase", "GMP synthase [glutamine-hydrolyzing]", "GPI-anchor transamidase", "GTP-binding nuclear protein Ran", "GTP-binding protein 1", "GTPase Era, mitochondrial", "GTPase-activating protein and VPS9 domain-containing protein 1", "Galactokinase", "Galactosidase", "Galectin-3", "Gamma-adducin", "Gamma-aminobutyric acid receptor-associated protein-like 2", "Gamma-enolase", "Gamma-glutamyl hydrolase", "Gamma-taxilin", "Gamma-tubulin complex component 2", "Gamma-tubulin complex component 3", "Ganglioside GM2 activator", "General transcription factor 3C polypeptide 3", "General transcription factor 3C polypeptide 5", "General transcription factor IIF subunit 1", "General vesicular transport factor p115", "Geranylgeranyl transferase type-2 subunit alpha", "Glia maturation factor beta", "Glucosamine-6-phosphate isomerase 1", "Glucose-6-phosphate 1-dehydrogenase", "Glucose-6-phosphate isomerase", "Glucosidase", "Glucosidase 2 subunit beta", "Glutamate dehydrogenase 1, mitochondrial", "Glutamate--cysteine ligase regulatory subunit", "Glutaminase kidney isoform, mitochondrial", "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1", "Glutamine--tRNA ligase", "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial", "Glutaredoxin-3", "Glutaredoxin-related protein 5, mitochondrial", "Glutathione reductase, mitochondrial", "Glutathione synthetase", "Glyceraldehyde-3-phosphate dehydrogenase", "Glycerol-3-phosphate dehydrogenase 1-like protein", "Glycerol-3-phosphate dehydrogenase, mitochondrial", "Glycerol-3-phosphate phosphatase", "Glycine dehydrogenase (decarboxylating), mitochondrial", "Glycine--tRNA ligase", "Glycogen debranching enzyme", "Glycogen phosphorylase, brain form", "Glycogen phosphorylase, liver form", "Glycogenin-1", "Glycosidase", "Glycosylase", "Glycosyltransferase", "Glycylpeptide N-tetradecanoyltransferase 1", "Glyoxylate reductase/hydroxypyruvate reductase", "Group XV phospholipase A2", "Growth factor", "GrpE protein homolog 1, mitochondrial", "Gtp:amp phosphotransferase ak3, mitochondrial", "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5", "Guanine nucleotide-binding protein G(i) subunit alpha-2", "Guanine nucleotide-binding protein G(k) subunit alpha", "Guanine nucleotide-binding protein subunit alpha-13", "Guanyl-nucleotide exchange factor", "H(+)/Cl(-) exchange transporter 3", "H/ACA ribonucleoprotein complex subunit 1", "H/ACA ribonucleoprotein complex subunit 2", "HBS1-like protein", "HDAC class I", "HDAC class III", "HEAT repeat-containing protein 1", "HEAT repeat-containing protein 6", "HIV Tat-specific factor 1", "Haloacid dehalogenase-like hydrolase domain-containing 5", "Haloacid dehalogenase-like hydrolase domain-containing protein 2", "Heat shock protein 75 kDa, mitochondrial", "Heat shock protein HSP 90-alpha", "Heat shock protein HSP 90-beta", "Helicase", "Hepatoma-derived growth factor", "Hepatoma-derived growth factor-related protein 2", "Heterogeneous nuclear ribonucleoprotein F", "Heterogeneous nuclear ribonucleoprotein H", "Heterogeneous nuclear ribonucleoprotein H2", "Heterogeneous nuclear ribonucleoprotein H3", "Heterogeneous nuclear ribonucleoprotein K", "Heterogeneous nuclear ribonucleoprotein M", "Heterogeneous nuclear ribonucleoprotein Q", "Heterogeneous nuclear ribonucleoprotein R", "Heterotrimeric G-protein", "Hexokinase family", "Hexokinase-1", "Hexokinase-2", "High affinity cationic amino acid transporter 1", "High mobility group protein B1", "High mobility group protein B2", "High mobility group protein B3", "High mobility group protein HMG-I/HMG-Y", "High mobility group protein HMGI-C", "Histidine triad nucleotide-binding protein 2, mitochondrial", "Histone", "Histone H1.0", "Histone H1.2", "Histone H1.3", "Histone H1.4", "Histone H1x", "Histone H2AX", "Histone H4", "Histone acetyltransferase KAT7", "Histone acetyltransferase type B catalytic subunit", "Histone deacetylase", "Histone deacetylase 1", "Histone deacetylase 2", "Histone deacetylase complex subunit SAP18", "Histone-arginine methyltransferase CARM1", "Histone-lysine N-methyltransferase EHMT1", "Histone-lysine N-methyltransferase NSD2", "Histone-lysine N-methyltransferase SETD2", "Histone-lysine N-methyltransferase SMYD3", "Hormone", "Hsp90 co-chaperone Cdc37", "Hsp90 family chaperone", "Hydrolase", "Hydroxylase", "Hypoxanthine-guanine phosphoribosyltransferase", "IKK family", "INSR family", "ITPK1 family", "Immune response", "Immunoglobulin fold transcription factor", "Immunoglobulin-binding protein 1", "Importin subunit alpha-1", "Importin subunit alpha-3", "Importin subunit alpha-4", "Importin subunit alpha-5", "Importin subunit alpha-7", "Importin subunit beta-1", "Importin-11", "Importin-4", "Importin-5", "Importin-7", "Importin-8", "Importin-9", "Inactive serine/threonine-protein kinase vrk3", "Inactive tyrosine-protein kinase 7", "Induced myeloid leukemia cell differentiation protein Mcl-1", "Inorganic pyrophosphatase", "Inorganic pyrophosphatase 2, mitochondrial", "Inosine triphosphate pyrophosphatase", "Inosine-5'-monophosphate dehydrogenase 2", "Inositol monophosphatase 3", "Inositol polyphosphate 5-phosphatase OCRL-1", "Inositol-tetrakisphosphate 1-kinase", "Insulin-degrading enzyme", "Insulin-like growth factor 1 receptor", "Insulin-like growth factor 2 mRNA-binding protein 1", "Insulin-like growth factor 2 mRNA-binding protein 2", "Insulin-like growth factor 2 mRNA-binding protein 3", "Integrin beta-1", "Integrin-linked kinase-associated serine/threonine phosphatase 2C", "Interferon gamma receptor 1", "Interferon-induced, double-stranded rna-activated protein kinase", "Interleukin enhancer-binding factor 3", "Intermediate filament", "Intermediate filament binding protein", "Intracellular calcium-sensing protein", "Intracellular chloride channel (clic) family", "Ion channel", "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial", "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial", "Isoleucine--tRNA ligase, cytoplasmic", "Isoleucine--tRNA ligase, mitochondrial", "Isomerase", "Isopentenyl-diphosphate Delta-isomerase 1", "Isovaleryl-CoA dehydrogenase, mitochondrial", "Jumonji domain-containing", "KH domain-containing, RNA-binding, signal transduction-associated protein 1", "KH domain-containing, RNA-binding, signal transduction-associated protein 3", "KRAB box transcription factor", "KRR1 small subunit processome component homolog", "Ketosamine-3-kinase", "Kinase", "Kinase activator", "Kinase inhibitor", "Kinase modulator", "Kinesin-1 heavy chain", "Kinesin-like protein KIF11", "Kinesin-like protein KIF14", "Kinesin-like protein KIF18A", "Kinesin-like protein KIF1A", "Kinesin-like protein KIF1B", "Kinesin-like protein KIF20A", "Kinesin-like protein KIF22", "Kinesin-like protein KIF23", "Kinesin-like protein KIF2A", "Kinesin-like protein KIF2C", "Kinetochore protein Nuf2", "Kynurenine--oxoglutarate transaminase 3", "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase", "L-lactate dehydrogenase A chain", "L-lactate dehydrogenase B chain", "LIM domain and actin-binding protein 1", "LU7TM family", "La-related protein 1", "La-related protein 4", "La-related protein 4B", "La-related protein 7", "Lamin-B receptor", "Lamina-associated polypeptide 2, isoform alpha", "Lanosterol 14-alpha demethylase", "Large neutral amino acids transporter small subunit 1", "Large proline-rich protein BAG6", "Lariat debranching enzyme", "Lethal(2) giant larvae protein homolog 1", "Leucine-rich repeat and WD repeat-containing protein 1", "Leucine-rich repeat-containing protein 47", "Leucyl-cystinyl aminopeptidase", "Ligase", "Lipase", "Lipid kinase", "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial", "Lon protease homolog, mitochondrial", "Long-chain fatty acid transport protein 4", "Long-chain-fatty-acid--CoA ligase 1", "Long-chain-fatty-acid--CoA ligase 3", "Long-chain-fatty-acid--CoA ligase 4", "Lupus La protein", "Lyase", "Lymphokine-activated killer t-cell-originated protein kinase", "Lysine demethylase", "Lysine--tRNA ligase", "Lysine-specific demethylase", "Lysine-specific demethylase 3B", "Lysine-specific histone demethylase 1A", "Lysine-specific histone demethylase 1B", "Lysophosphatidic acid phosphatase type 6", "Lysophosphatidylcholine acyltransferase 1", "Lysophospholipid acyltransferase 7", "Lysosomal Pro-X carboxypeptidase", "Lysosomal acid phosphatase", "Lysosomal alpha-glucosidase", "Lysosomal protective protein", "Lysosomal thioesterase PPT2", "Lysosome membrane protein 2", "Lysosome-associated membrane glycoprotein 1", "M-phase phosphoprotein 8", "MAGUK p55 subfamily member 2", "MAGUK p55 subfamily member 6", "MAGUK p55 subfamily member 7", "MAPK family", "MMS19 nucleotide excision repair protein homolog", "MOB-like protein phocein", "Magnesium transporter protein 1", "Major facilitator superfamily domain-containing protein 3", "Major histocompatibility complex antigen", "Malate dehydrogenase, cytoplasmic", "Malate dehydrogenase, mitochondrial", "Mannose-6-phosphate isomerase", "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial", "Melanoma inhibitory activity protein 2", "Melanoma-associated antigen D2", "Membralin", "Membrane trafficking regulatory protein", "Membrane-associated progesterone receptor component 1", "Membrane-associated progesterone receptor component 2", "Metalloprotease", "Metastasis-associated protein MTA1", "Metastasis-associated protein MTA2", "Methyl-CpG-binding domain", "Methyl-CpG-binding protein 2", "Methyl-lysine/arginine binding protein", "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial", "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial", "Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial", "Methylmalonyl-CoA mutase, mitochondrial", "Methylosome subunit pICln", "Methylsterol monooxygenase 1", "Methyltransferase", "Microfibrillar-associated protein 1", "Microsomal glutathione S-transferase 3", "Microtubule binding motor protein", "Microtubule family cytoskeletal protein", "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5", "Microtubule-associated protein 1B", "Microtubule-associated protein RP/EB family member 1", "Microtubule-associated protein RP/EB family member 2", "Minor histocompatibility antigen H13", "Miscellaneous SLC25 mitochondrial transporters", "Mitochondrial 2-oxodicarboxylate carrier", "Mitochondrial 2-oxoglutarate/malate carrier protein", "Mitochondrial Rho GTPase 1", "Mitochondrial Rho GTPase 2", "Mitochondrial amino acid transporter subfamily", "Mitochondrial cardiolipin hydrolase", "Mitochondrial carnitine/acylcarnitine carrier protein", "Mitochondrial carrier homolog 1", "Mitochondrial carrier homolog 2", "Mitochondrial di- and tri-carboxylic acid transporter subfamily", "Mitochondrial dicarboxylate carrier", "Mitochondrial folate transporter/carrier", "Mitochondrial import receptor subunit TOM20 homolog", "Mitochondrial import receptor subunit TOM40 homolog", "Mitochondrial inner membrane protein OXA1L", "Mitochondrial intermediate peptidase", "Mitochondrial nucleotide transporter subfamily", "Mitochondrial ornithine transporter 1", "Mitochondrial phosphate transporters", "Mitochondrial proton/calcium exchanger protein", "Mitochondrial thiamine pyrophosphate carrier", "Mitochondrial-processing peptidase subunit alpha", "Mitochondrial-processing peptidase subunit beta", "Mitofusin-1", "Mitofusin-2", "Mitogen-activated protein kinase 1", "Mitogen-activated protein kinase 14", "Mitotic checkpoint protein BUB3", "Mitotic checkpoint serine/threonine-protein kinase bub1 beta", "Moesin", "Molybdate-anion transporter", "Monoacylglycerol lipase ABHD12", "Monocarboxylate transporter 1", "Monofunctional C1-tetrahydrofolate synthase, mitochondrial", "Mortality factor 4-like protein 1", "Mortality factor 4-like protein 2", "Mpv17-like protein 2", "Multidrug resistance protein 1", "Multidrug resistance-associated protein 1", "Multifunctional protein ADE2", "Mutase", "Myb-binding protein 1A", "Myelin expression factor 2", "Myosin light chain 6B", "Myosin light polypeptide 6", "Myosin phosphatase Rho-interacting protein", "Myotubularin-related protein 6", "N(G),N(G)-dimethylarginine dimethylaminohydrolase 2", "N-acetylgalactosaminyltransferase 7", "N-acetylglucosamine-6-sulfatase", "N-acylneuraminate cytidylyltransferase", "N-alpha-acetyltransferase 15, NatA auxiliary subunit", "N-alpha-acetyltransferase 25, NatB auxiliary subunit", "N-alpha-acetyltransferase 35, NatC auxiliary subunit", "N-alpha-acetyltransferase 50", "N-terminal Xaa-Pro-Lys N-methyltransferase 1", "NAD(P) transhydrogenase, mitochondrial", "NAD-dependent malic enzyme, mitochondrial", "NAD-dependent protein deacetylase sirtuin-1", "NAD-dependent protein deacetylase sirtuin-2", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5", "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial", "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial", "NADH-ubiquinone oxidoreductase chain 1", "NADPH:adrenodoxin oxidoreductase, mitochondrial", "NAK family", "NEDD8-activating enzyme E1 catalytic subunit", "NEDD8-activating enzyme E1 regulatory subunit", "NEK family", "NF-kappa-B-repressing factor", "NHP2-like protein 1", "NSFL1 cofactor p47", "Na+/K+-ATPases", "Nardilysin", "Neuferricin", "Neurofibromin", "Neurolysin, mitochondrial", "Neutral alpha-glucosidase AB", "Neutral amino acid transporter B(0)", "Nicotinamide phosphoribosyltransferase", "Nipped-B-like protein", "Non-POU domain-containing octamer-binding protein", "Non-histone chromosomal protein HMG-17", "Non-motor actin binding protein", "Non-motor microtubule binding protein", "Non-protein kinase", "Nuclear RNA export factor 1", "Nuclear cap-binding protein subunit 1", "Nuclear migration protein nudC", "Nuclear pore complex protein Nup107", "Nuclear pore complex protein Nup153", "Nuclear pore complex protein Nup160", "Nuclear pore complex protein Nup214", "Nuclear pore complex protein Nup85", "Nuclear pore complex protein Nup88", "Nuclear pore complex protein Nup93", "Nuclear pore complex protein Nup98-Nup96", "Nuclear pore glycoprotein p62", "Nuclear pore membrane glycoprotein 210", "Nuclear receptor coactivator 5", "Nuclease", "Nucleic acid binding", "Nucleobindin-1", "Nucleobindin-2", "Nucleolar MIF4G domain-containing protein 1", "Nucleolar complex protein 4 homolog", "Nucleolar protein 14", "Nucleolar protein 56", "Nucleolar protein 58", "Nucleolar protein 6", "Nucleolar protein 9", "Nucleolin", "Nucleophosmin", "Nucleoporin Nup37", "Nucleoporin SEH1", "Nucleoporin p54", "Nucleoside diphosphate kinase A", "Nucleoside kinase", "Nucleosome assembly protein 1-like 1", "Nucleosome assembly protein 1-like 4", "Nucleotide kinase", "Nucleotide phosphatase", "Nucleotidyltransferase", "OCIA domain-containing protein 1", "Obg-like ATPase 1", "Origin recognition complex subunit 2", "Origin recognition complex subunit 3", "Origin recognition complex subunit 5", "Ornithine aminotransferase, mitochondrial", "Other 7TM proteins", "Other group", "Other small molecule kinase", "Oxidase", "Oxidoreductase", "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial", "Oxygenase", "P-type ATPases", "P38 subfamily", "P53-like transcription factor", "PAKA subfamily", "PC4 and SFRS1-interacting protein", "PDHK family", "PDZ and LIM domain protein 1", "PDZ and LIM domain protein 5", "PDZ domain-containing protein 11", "PEK family", "PH-interacting protein", "PHD finger protein 3", "PHD finger protein 6", "PI3/PI4 kinase family", "PIKK family", "PITSLRE subfamily", "PKA family", "PKC alpha subfamily", "PKC family", "PKN family", "PLK family", "Paired amphipathic helix protein Sin3a", "Palmitoyl-protein thioesterase 1", "Pantothenate kinase 4", "Paraspeckle component 1", "Pentatricopeptide repeat-containing protein 1, mitochondrial", "Peptidyl-prolyl cis-trans isomerase FKBP1A", "Peptidyl-prolyl cis-trans isomerase FKBP4", "Peptidyl-prolyl cis-trans isomerase FKBP5", "Peptidyl-prolyl cis-trans isomerase-like 1", "Perilipin-3", "Periodic tryptophan protein 1 homolog", "Peripheral plasma membrane protein cask", "Peroxidase", "Peroxiredoxin-2", "Peroxiredoxin-4", "Peroxiredoxin-6", "Peroxisomal NADH pyrophosphatase NUDT12", "Peroxisomal acyl-coenzyme A oxidase 1", "Peroxisomal acyl-coenzyme A oxidase 3", "Peroxisomal biogenesis factor 19", "Peroxisomal membrane protein 2", "Peroxisomal membrane protein PEX14", "Peroxisomal membrane protein PMP34", "Peroxisomal trans-2-enoyl-CoA reductase", "Pescadillo homolog", "Phenylalanine--tRNA ligase beta subunit", "Phosphatase", "Phosphatase activator", "Phosphatase inhibitor", "Phosphatase modulator", "Phosphate carrier protein, mitochondrial", "Phosphatidylethanolamine-binding protein 1", "Phosphatidylinositol 4-kinase alpha", "Phosphatidylinositol 4-kinase type 2-alpha", "Phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit alpha", "Phosphatidylinositol transfer protein beta isoform", "Phosphatidylinositol-binding clathrin assembly protein", "Phosphodiesterase", "Phosphoenolpyruvate carboxykinase [GTP] family", "Phosphoenolpyruvate carboxykinase [gtp], mitochondrial", "Phosphofructokinase type A (PFKA) family", "Phosphoglycerate kinase 1", "Phosphoglycerate kinase family", "Phosphoinositide 3-kinase (PI3K) family", "Phosphoinositide 3-kinase regulatory subunit 4", "Phospholipase", "Phospholipase A-2-activating protein", "Phospholipid-transporting ATPase IG", "Phospholipid-transporting ATPases", "Phosphoribosyl pyrophosphate synthase-associated protein 1", "Phosphoribosyl pyrophosphate synthase-associated protein 2", "Phosphoribosyltransferase domain-containing protein 1", "Phosphorylase", "Phosphorylated adapter RNA export protein", "Pirin", "Plasma membrane calcium-transporting ATPase 1", "Plasminogen activator inhibitor 1 RNA-binding protein", "Plastin-1", "Plastin-3", "Plectin", "Pogo transposable element with ZNF domain", "Poly(A) RNA polymerase, mitochondrial", "Poly(A) polymerase alpha", "Poly(A)-specific ribonuclease PARN", "Poly(rC)-binding protein 1", "Poly(rC)-binding protein 2", "Polyadenylate-binding protein-interacting protein 1", "Polycomb protein SUZ12", "Polyhomeotic-like protein 2", "Polymerase", "Polymerase delta-interacting protein 3", "Polypeptide N-acetylgalactosaminyltransferase 1", "Polypeptide N-acetylgalactosaminyltransferase 2", "Polyribonucleotide nucleotidyltransferase 1, mitochondrial", "Porphobilinogen deaminase", "Pre-mRNA-processing factor 6", "Pre-mRNA-processing-splicing factor 8", "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15", "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16", "Pre-mRNA-splicing factor CWC22 homolog", "Pre-mRNA-splicing factor RBM22", "Pre-mRNA-splicing factor SPF27", "Pre-mRNA-splicing factor SYF1", "Prefoldin subunit 2", "Prefoldin subunit 3", "Prefoldin subunit 5", "Presequence protease, mitochondrial", "Primase", "Probable ATP-dependent RNA helicase DHX34", "Probable ATP-dependent RNA helicase DHX35", "Probable ATP-dependent RNA helicase DHX37", "Probable ATP-dependent RNA helicase DHX40", "Probable E3 ubiquitin-protein ligase makorin-2", "Probable RNA-binding protein 19", "Probable U3 small nucleolar RNA-associated protein 11", "Probable global transcription activator SNF2L1", "Probable glutamate--tRNA ligase, mitochondrial", "Probable glutathione peroxidase 8", "Probable helicase with zinc finger domain", "Probable leucine--tRNA ligase, mitochondrial", "Probable ribosome biogenesis protein RLP24", "Probable serine carboxypeptidase CPVL", "Probable tRNA N6-adenosine threonylcarbamoyltransferase", "Probable tRNA pseudouridine synthase 1", "Procollagen galactosyltransferase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2", "Programmed cell death 6-interacting protein", "Programmed cell death protein 4", "Programmed cell death protein 5", "Prolactin regulatory element-binding protein", "Proliferating cell nuclear antigen", "Prolyl 3-hydroxylase 1", "Prolyl endopeptidase", "Propionyl-CoA carboxylase alpha chain, mitochondrial", "Propionyl-CoA carboxylase beta chain, mitochondrial", "Prostaglandin E synthase 2", "Prostaglandin E synthase 3", "Prostaglandin reductase 1", "Prostaglandin reductase 2", "Prostaglandin reductase 3", "Protease", "Protease inhibitor", "Protein AATF", "Protein BUD31 homolog", "Protein CMSS1", "Protein DDI1 homolog 2", "Protein ERGIC-53", "Protein FAM177A1", "Protein FRG1", "Protein LSM14 homolog A", "Protein NDRG3", "Protein PRRC2A", "Protein PRRC2C", "Protein RRP5 homolog", "Protein Red", "Protein S100-A11", "Protein SCO1 homolog, mitochondrial", "Protein SCO2 homolog, mitochondrial", "Protein SEC13 homolog", "Protein SET", "Protein Wiz", "Protein arginine N-methyltransferase 1", "Protein arginine N-methyltransferase 3", "Protein arginine N-methyltransferase 5", "Protein arginine methyltransferase", "Protein farnesyltransferase subunit beta", "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "Protein gpr107", "Protein kinase", "Protein kinase C and casein kinase substrate in neurons protein 2", "Protein kinase C and casein kinase substrate in neurons protein 3", "Protein kinase c beta type", "Protein lin-28 homolog B", "Protein methyltransferase", "Protein phosphatase", "Protein phosphatase 1F", "Protein phosphatase 1G", "Protein polybromo-1", "Protein quaking", "Protein regulator of cytokinesis 1", "Protein strawberry notch homolog 1", "Protein transport protein Sec23A", "Protein transport protein Sec23B", "Protein transport protein Sec24A", "Protein transport protein Sec24C", "Protein transport protein Sec31A", "Protein transport protein Sec61 subunit alpha isoform 1", "Protein tweety homolog 3", "Protein unc-119 homolog A", "Protein unc-119 homolog B", "Protein-L-isoaspartate(D-aspartate) O-methyltransferase", "Protein/nucleic acid deglycase DJ-1", "Pseudouridine-5'-phosphatase", "Pterin-4-alpha-carbinolamine dehydratase", "Pumilio homolog 1", "Purine nucleoside phosphorylase", "Puromycin-sensitive aminopeptidase", "Putative ATP-dependent RNA helicase DHX57", "Putative oxidoreductase GLYR1", "Putative phospholipase B-like 2", "Pyrophosphatase", "Pyruvate carboxylase, mitochondrial", "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial", "Pyruvate kinase pkm", "RAD53 family", "RIPK family", "RNA 3'-terminal phosphate cyclase-like protein", "RNA binding motif protein, X-linked-like-1", "RNA binding protein", "RNA helicase", "RNA-binding motif protein, X chromosome", "RNA-binding protein 12", "RNA-binding protein 12B", "RNA-binding protein 14", "RNA-binding protein 26", "RNA-binding protein 3", "RNA-binding protein 4", "RNA-binding protein EWS", "RNA-binding protein FUS", "RNA-binding protein Nova-2", "RNA-binding protein with serine-rich domain 1", "ROCK subfamily", "RSK family", "RSK subfamily", "Rab GDP dissociation inhibitor alpha", "Rab GDP dissociation inhibitor beta", "Rab GTPase-activating protein 1", "Rab3 GTPase-activating protein non-catalytic subunit", "Rac GTPase-activating protein 1", "Rac-beta serine/threonine-protein kinase", "Radixin", "RalBP1-associated Eps domain-containing protein 1", "Ran GTPase-activating protein 1", "Ran-binding protein 3", "Ran-binding protein 9", "Ran-specific GTPase-activating protein", "Rap guanine nucleotide exchange factor 2", "Ras GTPase-activating protein-binding protein 1", "Ras GTPase-activating protein-binding protein 2", "Ras GTPase-activating-like protein IQGAP1", "Ras GTPase-activating-like protein IQGAP2", "Ras-related C3 botulinum toxin substrate 1", "Ras-related protein Ral-A", "Reader", "Receptor", "Receptor expression-enhancing protein 5", "Receptor-interacting serine/threonine-protein kinase 1", "Receptor-type tyrosine-protein phosphatase F", "Recombining binding protein suppressor of hairless", "Reductase", "Regulation of nuclear pre-mRNA domain-containing protein 1A", "Regulation of nuclear pre-mRNA domain-containing protein 1B", "Regulation of nuclear pre-mRNA domain-containing protein 2", "Regulator of nonsense transcripts 1", "Regulator of nonsense transcripts 2", "Remodeling and spacing factor 1", "Replication factor C subunit 2", "Replication factor C subunit 3", "Replication factor C subunit 4", "Replication factor C subunit 5", "Replication origin binding protein", "Replication protein A 70 kDa DNA-binding subunit", "Reticulocalbin-1", "Reticulocalbin-2", "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "Retinoid-inducible serine carboxypeptidase", "Retinol dehydrogenase 11", "Rho GDP-dissociation inhibitor 1", "Rho-associated protein kinase 1", "Rho-related GTP-binding protein RhoG", "Ribonuclease H2 subunit A", "Ribonuclease P protein subunit p20", "Ribonuclease P protein subunit p30", "Ribonuclease inhibitor", "Ribonucleoprotein", "Ribonucleoprotein PTB-binding 1", "Ribonucleoside-diphosphate reductase large subunit", "Ribonucleoside-diphosphate reductase subunit M2", "Ribosomal L1 domain-containing protein 1", "Ribosomal RNA small subunit methyltransferase NEP1", "Ribosomal protein", "Ribosomal protein s6 kinase alpha-1", "Ribosomal protein s6 kinase alpha-3", "Ribosome biogenesis protein BOP1", "Ribosome biogenesis protein BRX1 homolog", "Ribosome biogenesis regulatory protein homolog", "Ribosome maturation protein SBDS", "Ribosome production factor 1", "Ribosome production factor 2 homolog", "S-adenosylhomocysteine hydrolase-like protein 1", "S-adenosylmethionine mitochondrial carrier protein", "S-adenosylmethionine synthase isoform type-2", "S-formylglutathione hydrolase", "S-methyl-5'-thioadenosine phosphorylase", "S-phase kinase-associated protein 1", "SAP30-binding protein", "SCY1 family", "SEC23-interacting protein", "SET domain", "SLC superfamily of solute carriers", "SLC1 family of amino acid transporters", "SLC12 family of cation-coupled chloride transporters", "SLC16 family of monocarboxylate transporters", "SLC2 family of hexose and sugar alcohol transporters", "SLC22 family of organic cation and anion transporters", "SLC25 family of mitochondrial transporters", "SLC27 family of fatty acid transporters", "SLC3 and SLC7 families of heteromeric amino acid transporters (HATs)", "SLC3 family", "SLC30 zinc transporter family", "SLC35 family of nucleotide sugar transporters", "SLC38 family of sodium-dependent neutral amino acid transporters", "SLC55 Mitochondrial cation/proton exchangers", "SLC56 Sideroflexins", "SLC58 MagT-like magnesium transporter family", "SLC61 Molybdate transporter family", "SLC7 family", "SLC9 family of sodium/hydrogen exchangers", "SLK subfamily", "SNARE protein", "SNW domain-containing protein 1", "SRPK family", "STE group", "STE20 family", "STE7 family", "SUMO-activating enzyme subunit 1", "SUMO-activating enzyme subunit 2", "SUN domain-containing protein 1", "SUN domain-containing protein 2", "SURP and G-patch domain-containing protein 1", "SURP and G-patch domain-containing protein 2", "SWI/SNF complex subunit SMARCC1", "SWI/SNF complex subunit SMARCC2", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1", "Sal-like protein 2", "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "Scavenger receptor class B member 1", "Scy1-like protein 2", "Sec1 family domain-containing protein 1", "Secretory carrier-associated membrane protein 2", "Secretory carrier-associated membrane protein 3", "Secretory carrier-associated membrane protein 4", "Selenide, water dikinase 1", "Selenocysteine-specific elongation factor", "Sentrin-specific protease 3", "Septin-11", "Septin-2", "Septin-7", "Septin-9", "Serine hydroxymethyltransferase, mitochondrial", "Serine palmitoyltransferase 1", "Serine palmitoyltransferase 2", "Serine protease", "Serine protease inhibitor", "Serine--tRNA ligase, cytoplasmic", "Serine--tRNA ligase, mitochondrial", "Serine/arginine repetitive matrix protein 1", "Serine/arginine-rich splicing factor 1", "Serine/arginine-rich splicing factor 10", "Serine/arginine-rich splicing factor 11", "Serine/arginine-rich splicing factor 3", "Serine/arginine-rich splicing factor 4", "Serine/arginine-rich splicing factor 5", "Serine/arginine-rich splicing factor 6", "Serine/arginine-rich splicing factor 7", "Serine/arginine-rich splicing factor 9", "Serine/threonine-protein kinase chk2", "Serine/threonine-protein kinase mtor", "Serine/threonine-protein kinase n2", "Serine/threonine-protein kinase nek9", "Serine/threonine-protein kinase pak 2", "Serine/threonine-protein kinase plk1", "Serine/threonine-protein kinase prp4 homolog", "Serine/threonine-protein kinase tao1", "Serine/threonine-protein kinase tbk1", "Serine/threonine-protein kinase vrk1", "Serine/threonine-protein kinase wnk1", "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform", "Serine/threonine-protein phosphatase 2A activator", "Serine/threonine-protein phosphatase 6 regulatory subunit 3", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit", "Serine/threonine-protein phosphatase PP1-beta catalytic subunit", "Serpin B6", "Serpin H1", "Sex comb on midleg-like protein 2", "Sialic acid synthase", "Sideroflexin-1", "Sideroflexin-2", "Sigma intracellular receptor 2", "Signal peptidase complex catalytic subunit SEC11A", "Signal peptidase complex subunit 2", "Signal peptidase complex subunit 3", "Signal recognition particle 14 kDa protein", "Signal recognition particle 54 kDa protein", "Signal recognition particle 9 kDa protein", "Signal recognition particle receptor subunit alpha", "Signal recognition particle subunit SRP68", "Signal transducer and activator of transcription 1-alpha/beta", "Signal transducer and activator of transcription 3", "Signaling", "Single-stranded DNA-binding protein, mitochondrial", "Sister chromatid cohesion protein PDS5 homolog A", "Sister chromatid cohesion protein PDS5 homolog B", "Small GTPase", "Small nuclear ribonucleoprotein E", "Small nuclear ribonucleoprotein Sm D1", "Small nuclear ribonucleoprotein Sm D2", "Small nuclear ribonucleoprotein Sm D3", "Sodium-coupled neutral amino acid transporter 1", "Sodium/hydrogen exchanger 6", "Sodium/potassium-transporting ATPase subunit alpha-1", "Sodium/potassium-transporting ATPase subunit beta-1", "Sodium/potassium-transporting ATPase subunit beta-3", "Solute carrier family 12 member 2", "Solute carrier family 2, facilitated glucose transporter member 1", "Solute carrier family 35 member F2", "Something about silencing protein 10", "Sorbitol dehydrogenase", "Sortilin", "Sorting nexin-1", "Sorting nexin-2", "Spermatid perinuclear RNA-binding protein", "Spermidine synthase", "Splicing factor 1", "Splicing factor 3A subunit 1", "Splicing factor 3A subunit 2", "Splicing factor 3A subunit 3", "Splicing factor 3B subunit 1", "Splicing factor 3B subunit 3", "Splicing factor 45", "Splicing factor, arginine/serine-rich 15", "Splicing factor, proline- and glutamine-rich", "Splicing factor, suppressor of white-apricot homolog", "Splicing regulatory glutamine/lysine-rich protein 1", "Squalene monooxygenase", "Squamous cell carcinoma antigen recognized by T-cells 3", "Src substrate cortactin", "Srsf protein kinase 1", "Staphylococcal nuclease domain-containing protein 1", "Ste20-like serine/threonine-protein kinase", "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating", "Stomatin-like protein 2, mitochondrial", "Storage", "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial", "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial", "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial", "Succinate-semialdehyde dehydrogenase, mitochondrial", "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial", "Sulfhydryl oxidase 2", "Superoxide dismutase [Mn], mitochondrial", "Surfeit locus protein 4", "Surfeit locus protein 6", "Survival motor neuron protein", "Switch-associated protein 70", "Synaptic functional regulator FMR1", "Synaptic vesicle glycoprotein 2A", "Synaptogyrin-2", "Synaptosomal-associated protein 23", "Synaptosomal-associated protein 29", "Syntaxin-12", "Syntaxin-18", "Syntaxin-4", "Syntaxin-5", "Syntaxin-7", "Syntaxin-8", "Syntaxin-binding protein 3", "System A-like transporters", "T-complex protein 1 subunit alpha", "T-complex protein 1 subunit beta", "T-complex protein 1 subunit delta", "T-complex protein 1 subunit epsilon", "T-complex protein 1 subunit eta", "T-complex protein 1 subunit gamma", "T-complex protein 1 subunit theta", "T-complex protein 1 subunit zeta", "TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L", "TAO subfamily", "TATA-binding protein-associated factor 2N", "TBC1 domain family member 10B", "TBC1 domain family member 15", "TBC1 domain family member 4", "TBC1 domain family member 8B", "TBC1 domain family member 9B", "THO complex subunit 1", "THO complex subunit 2", "THO complex subunit 3", "THO complex subunit 4", "TK group", "TKL group", "TOPK family", "TP53-binding protein 1", "Targeting protein for Xklp2", "Testin", "Testis-specific Y-encoded-like protein 1", "Tgf-beta-activated kinase 1 and map3k7-binding protein 1", "Thimet oligopeptidase", "Thioredoxin domain-containing protein 12", "Thioredoxin domain-containing protein 17", "Thioredoxin domain-containing protein 9", "Thioredoxin reductase 1, cytoplasmic", "Thioredoxin reductase 2, mitochondrial", "Thioredoxin-dependent peroxide reductase, mitochondrial", "Thiosulfate sulfurtransferase", "Threonine--tRNA ligase, cytoplasmic", "Threonine--tRNA ligase, mitochondrial", "Thymidine kinase family", "Thymidine kinase, cytosolic", "Thymidylate kinase", "Thymidylate kinase family", "Thymidylate synthase", "Thyroid hormone receptor-associated protein 3", "Tight junction", "Tight junction protein ZO-1", "Trafficking protein particle complex subunit 4", "Trans-Golgi network integral membrane protein 2", "Transaminase", "Transcription activator BRG1", "Transcription cofactor", "Transcription elongation factor A protein 1", "Transcription elongation factor SPT6", "Transcription elongation regulator 1", "Transcription factor", "Transcription factor 20", "Transcription initiation factor TFIID subunit 2", "Transcriptional activator protein Pur-alpha", "Transcriptional repressor CTCF", "Transcriptional repressor p66-alpha", "Transcriptional repressor p66-beta", "Transferase", "Transferrin receptor protein 1", "Transformer-2 protein homolog alpha", "Transformer-2 protein homolog beta", "Transgelin-2", "Transketolase", "Translation elongation factor", "Translation factor", "Translation initiation factor", "Translation initiation factor IF-2, mitochondrial", "Translation release factor", "Translationally-controlled tumor protein", "Translocation protein SEC63 homolog", "Translocon-associated protein subunit alpha", "Transmembrane 9 superfamily member 2", "Transmembrane 9 superfamily member 3", "Transmembrane 9 superfamily member 4", "Transmembrane emp24 domain-containing protein 10", "Transmembrane emp24 domain-containing protein 2", "Transmembrane emp24 domain-containing protein 4", "Transmembrane emp24 domain-containing protein 5", "Transmembrane emp24 domain-containing protein 7", "Transmembrane emp24 domain-containing protein 9", "Transmembrane protein 115", "Transport and Golgi organization protein 1 homolog", "Transporter", "Transportin-1", "Transportin-3", "Tricarboxylate transport protein, mitochondrial", "Trifunctional enzyme subunit alpha, mitochondrial", "Trifunctional enzyme subunit beta, mitochondrial", "Trifunctional purine biosynthetic protein adenosine-3", "Triosephosphate isomerase", "Tripeptidyl-peptidase 1", "Tripeptidyl-peptidase 2", "Tropomodulin-3", "Tropomyosin alpha-1 chain", "Tropomyosin alpha-3 chain", "Tropomyosin alpha-4 chain", "Trypsin-3", "Tryptophan--tRNA ligase, cytoplasmic", "Tubulin", "Tubulin beta chain", "Tubulin beta-2B chain", "Tubulin beta-4B chain", "Tubulin beta-6 chain", "Tubulin polyglutamylase TTLL4", "Tubulin-folding cofactor B", "Tubulin-specific chaperone A", "Tubulin-specific chaperone D", "Tubulin-specific chaperone E", "Tudor domain", "Tuftelin-interacting protein 11", "Tumor susceptibility gene 101 protein", "Twinfilin-1", "Twinkle protein, mitochondrial", "Type II PI4K subfamily", "Type II cytokine receptor", "Type III PI4K subfamily", "Tyrosine--tRNA ligase, cytoplasmic", "Tyrosine--tRNA ligase, mitochondrial", "Tyrosine-protein kinase csk", "U1 small nuclear ribonucleoprotein 70 kDa", "U1 small nuclear ribonucleoprotein A", "U2 small nuclear ribonucleoprotein A'", "U2 small nuclear ribonucleoprotein B''", "U2 snRNP-associated SURP motif-containing protein", "U3 small nucleolar RNA-associated protein 14 homolog A", "U3 small nucleolar RNA-associated protein 6 homolog", "U3 small nucleolar ribonucleoprotein protein IMP3", "U3 small nucleolar ribonucleoprotein protein IMP4", "U3 small nucleolar ribonucleoprotein protein MPP10", "U4/U6 small nuclear ribonucleoprotein Prp3", "U4/U6 small nuclear ribonucleoprotein Prp31", "U4/U6 small nuclear ribonucleoprotein Prp4", "U4/U6.U5 tri-snRNP-associated protein 1", "U4/U6.U5 tri-snRNP-associated protein 2", "U6 snRNA-associated Sm-like protein LSm2", "U6 snRNA-associated Sm-like protein LSm4", "U6 snRNA-associated Sm-like protein LSm6", "U6 snRNA-associated Sm-like protein LSm7", "U6 snRNA-associated Sm-like protein LSm8", "UDP-glucose:glycoprotein glucosyltransferase 1", "UMP-CMP kinase", "UV excision repair protein RAD23 homolog B", "Ubiquitin carboxyl-terminal hydrolase 10", "Ubiquitin carboxyl-terminal hydrolase 11", "Ubiquitin carboxyl-terminal hydrolase 14", "Ubiquitin carboxyl-terminal hydrolase 19", "Ubiquitin carboxyl-terminal hydrolase 28", "Ubiquitin carboxyl-terminal hydrolase 33", "Ubiquitin carboxyl-terminal hydrolase 36", "Ubiquitin carboxyl-terminal hydrolase 47", "Ubiquitin carboxyl-terminal hydrolase 5", "Ubiquitin carboxyl-terminal hydrolase 7", "Ubiquitin carboxyl-terminal hydrolase 8", "Ubiquitin carboxyl-terminal hydrolase isozyme L5", "Ubiquitin conjugation factor E4 A", "Ubiquitin thioesterase OTUB1", "Ubiquitin-conjugating enzyme E2 L3", "Ubiquitin-like modifier-activating enzyme 1", "Ubiquitin-like modifier-activating enzyme 6", "Ubiquitin-protein ligase", "Unclassified protein", "Unconventional myosin-Ib", "Unconventional myosin-Ic", "Unconventional myosin-Id", "Unconventional myosin-VI", "V-type ATPase", "V-type proton ATPase 116 kDa subunit a isoform 1", "V-type proton ATPase 116 kDa subunit a isoform 2", "V-type proton ATPase catalytic subunit A", "V-type proton ATPase subunit B, brain isoform", "V-type proton ATPase subunit C 1", "V-type proton ATPase subunit D", "V-type proton ATPase subunit H", "V-type proton ATPase subunit d 1", "VPS15 family", "VRK family", "Vacuolar protein sorting-associated protein 26A", "Vacuolar protein sorting-associated protein 29", "Vacuolar protein sorting-associated protein 33A", "Vacuolar protein sorting-associated protein 33B", "Vacuolar protein sorting-associated protein 35", "Vacuolar protein sorting-associated protein 4A", "Vacuolar protein sorting-associated protein 4B", "Vacuole membrane protein 1", "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial", "Very-long-chain enoyl-CoA reductase", "Vesicle coat protein", "Vesicle-associated membrane protein 7", "Vesicle-associated membrane protein-associated protein A", "Vesicle-associated membrane protein-associated protein B/C", "Vesicle-fusing ATPase", "Vesicular integral-membrane protein VIP36", "Voltage-dependent calcium channel subunit alpha-2/delta-1", "WD repeat and HMG-box DNA-binding protein 1", "WD repeat-containing protein 1", "WD repeat-containing protein 82", "WNK family", "Writer", "X-ray repair cross-complementing protein 5", "X-ray repair cross-complementing protein 6", "Xaa-Pro dipeptidase", "YEATS domain-containing protein 2", "YLP motif-containing protein 1", "Zinc finger CCCH domain-containing protein 11A", "Zinc finger CCCH domain-containing protein 15", "Zinc finger CCCH domain-containing protein 7A", "Zinc finger MYM-type protein 4", "Zinc finger RNA-binding protein", "Zinc finger and BTB domain-containing protein 10", "Zinc finger transcription factor", "Zinc transporter 7", "Zyxin", "[pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial", "c-Myc-binding protein", "eIF-2-alpha kinase activator GCN1", "eukaryotic two domain clade \"e\" sub-subfamily", "m7GpppX diphosphatase", "mRNA export factor", "mRNA polyadenylation factor", "mRNA processing factor", "mRNA splicing factor", "pre-mRNA 3' end processing protein WDR33", "rRNA 2'-O-methyltransferase fibrillarin", "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6", "tRNA (cytosine(34)-C(5))-methyltransferase"], "available_proteins": ["AACS", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AATF", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCF1", "ABCF2", "ABCF3", "ABHD12", "ACAA2", "ACAD11", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADPGK", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGL", "AHCY", "AHCYL1", "AIFM1", "AIMP1", "AIP", "AK1", "AK2", "AK3", "AK6", "AKAP1", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALG1", "ALYREF", "AMPD2", "ANAPC1", "ANO6", "ANP32A", "ANP32B", "ANP32E", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APLP2", "APOBEC3C", "APOL2", "ARCN1", "ARFIP1", "ARFIP2", "ARG2", "ARHGDIA", "ARID3B", "ARIH1", "ARIH2", "ARPC1A", "ARPC3", "ARPC4", "ASAH1", "ASNA1", "ASNS", "ATAD2", "ATAD3A", "ATAD3B", "ATIC", "ATP11C", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN2L", "AUP1", "BAG6", "BAIAP2", "BCAP31", "BCAS2", "BCLAF1", "BLMH", "BLVRA", "BLVRB", "BOP1", "BPNT1", "BRD2", "BRIX1", "BUB1B", "BUB3", "BUD31", "BZW1", "BZW2", "CAB39", "CACNA2D1", "CACYBP", "CAD", "CALR", "CALU", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASK", "CBX1", "CBX3", "CBX5", "CCAR1", "CCAR2", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2BP2", "CDC37", "CDC42", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDKN2AIP", "CEBPZ", "CEP170", "CEPT1", "CFAP20", "CHAF1A", "CHAF1B", "CHEK2", "CHERP", "CHKA", "CHMP4B", "CHMP5", "CHMP6", "CHMP7", "CHORDC1", "CHTOP", "CIRBP", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLIC1", "CLIC4", "CLNS1A", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT7", "CNP", "COIL", "COLEC12", "COLGALT1", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS3", "COPS5", "COPS6", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX2", "COX5A", "COX5B", "COX7A2", "COX7C", "CPOX", "CPSF1", "CPSF3", "CPSF7", "CPT2", "CPVL", "CRNKL1", "CRTAP", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNND1", "CTPS1", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL4B", "CUL5", "CWC22", "CYB5B", "CYB5D2", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DBN1", "DBNL", "DBR1", "DBT", "DCAF13", "DCPS", "DCTN1", "DCTN2", "DDAH2", "DDB1", "DDI2", "DDOST", "DENR", "DERL1", "DERL2", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX29", "DHX34", "DHX35", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIEXF", "DIS3", "DLD", "DLGAP5", "DLST", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPH5", "DPM1", "DPP3", "DPYSL2", "DSG2", "DSP", "DTYMK", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "DYNLL2", "DYNLT1", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC4", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EIF2A", "EIF2AK2", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3H", "EIF3I", "EIF3J", "EIF3L", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELMOD2", "ELOB", "ELOC", "ELP1", "ELP3", "EMC2", "EMG1", "ENO1", "ENO2", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC4", "ERH", "ERI1", "ERMP1", "ERO1A", "ERP29", "ESD", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC5", "EXOC6", "EXOC7", "EXOSC1", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "FAHD1", "FAM177A1", "FARSB", "FASN", "FBL", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FKBP1A", "FKBP4", "FKBP5", "FMR1", "FN3KRP", "FNTA", "FNTB", "FOXRED1", "FRG1", "FSCN1", "FUBP1", "FUBP3", "FUS", "FXR1", "FXR2", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GCAT", "GCFC2", "GCLM", "GCN1", "GDI1", "GDI2", "GFPT1", "GGH", "GINS2", "GLB1", "GLB1L2", "GLDC", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNG5", "GNPDA1", "GNS", "GPATCH4", "GPD1L", "GPD2", "GPI", "GPR107", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSPT1", "GSR", "GSS", "GTF2F1", "GTF3C3", "GTF3C5", "GTPBP1", "GYG1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACL1", "HADHA", "HADHB", "HAT1", "HBS1L", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HEATR1", "HEATR6", "HELZ", "HEXA", "HEXB", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HM13", "HMBS", "HMGA1", "HMGA2", "HMGB1", "HMGB2", "HMGB3", "HMGN2", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HPRT1", "HSD17B10", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPE1", "HTATSF1", "HUWE1", "IARS", "IARS2", "IDE", "IDH3A", "IDH3B", "IDI1", "IFNGR1", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF3", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "ITCH", "ITGB1", "ITPA", "ITPK1", "IVD", "JMJD6", "KARS", "KAT7", "KCTD12", "KDM1A", "KDM1B", "KDM3B", "KHDRBS1", "KHDRBS3", "KHSRP", "KIF11", "KIF14", "KIF18A", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "KYAT3", "LAMP1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS2", "LBR", "LDHA", "LDHB", "LETM1", "LGALS3", "LIG3", "LIMA1", "LIN28B", "LLGL1", "LMAN1", "LMAN2", "LNPEP", "LONP1", "LPCAT1", "LRRC47", "LRWD1", "LSM14A", "LSM2", "LSM4", "LSM6", "LSM7", "LSM8", "M6PR", "MACF1", "MAGED2", "MAGT1", "MANBA", "MAP1B", "MAP2K1", "MAP2K4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MAT2A", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "ME2", "MECP2", "MFAP1", "MFN1", "MFN2", "MFSD3", "MFSD5", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MIPEP", "MKRN2", "MMS19", "MOB4", "MORF4L1", "MORF4L2", "MPG", "MPHOSPH10", "MPHOSPH8", "MPI", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17L2", "MRPL1", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL24", "MRPL38", "MRPL39", "MRPL41", "MRPL43", "MRPL44", "MRPL47", "MRPL51", "MRPL9", "MRPS11", "MRPS2", "MRPS27", "MRPS35", "MRPS5", "MRPS7", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTA2", "MTAP", "MTCH1", "MTCH2", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MUT", "MYBBP1A", "MYCBP", "MYEF2", "MYL6", "MYL6B", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA35", "NAA50", "NAE1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NCAPD2", "NCAPD3", "NCBP1", "NCL", "NCOA5", "ND1", "NDRG3", "NDUFA10", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA9", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS6", "NDUFS7", "NEDD4L", "NEK9", "NF1", "NHP2", "NIPBL", "NKRF", "NLN", "NME1", "NMT1", "NNT", "NOC4L", "NOL6", "NOM1", "NONO", "NOP14", "NOP56", "NOP58", "NOP9", "NOVA2", "NPEPPS", "NPM1", "NRDC", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSUN2", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDC", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUP107", "NUP153", "NUP160", "NUP210", "NUP214", "NUP37", "NUP54", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXF1", "OAT", "OCIAD1", "OCRL", "OLA1", "OPA1", "ORC2", "ORC3", "ORC5", "OSGEP", "OTUB1", "OXA1L", "OXCT1", "P3H1", "P3H4", "PACSIN2", "PACSIN3", "PAICS", "PAIP1", "PAK2", "PANK4", "PAPOLA", "PAPSS1", "PAPSS2", "PARK7", "PARN", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PDCD11", "PDCD4", "PDCD5", "PDCD6IP", "PDE12", "PDE6D", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PDZD11", "PEBP1", "PECR", "PEPD", "PES1", "PEX14", "PEX19", "PFDN2", "PFDN5", "PFKL", "PFKM", "PFKP", "PGD", "PGK1", "PGLS", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHC2", "PHF3", "PHF6", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PICALM", "PIGK", "PIK3C2A", "PIK3R4", "PIR", "PITPNB", "PITRM1", "PKM", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNP", "PNPT1", "POGZ", "POLD2", "POLDIP3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "POP7", "PPA1", "PPA2", "PPAT", "PPIL1", "PPM1F", "PPM1G", "PPP1CA", "PPP1CB", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP6R3", "PPT1", "PPT2", "PRC1", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX6", "PREB", "PREP", "PRIM1", "PRKAA1", "PRKACA", "PRKAG1", "PRKCB", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF3", "PRPF31", "PRPF4", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC2A", "PRRC2C", "PRSS3", "PRTFDC1", "PSIP1", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD7", "PSMD8", "PSPC1", "PTCD1", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPRF", "PUDP", "PUM1", "PURA", "PWP1", "PXMP2", "PYGB", "PYGL", "QARS", "QKI", "QSOX2", "RAB3GAP2", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RAD23B", "RAE1", "RALA", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAPGEF2", "RAVER1", "RBBP6", "RBM12", "RBM12B", "RBM14", "RBM17", "RBM19", "RBM22", "RBM26", "RBM3", "RBM4", "RBMX", "RBMXL1", "RBPJ", "RCL1", "RCN1", "RCN2", "RDH11", "RDX", "RECQL", "REEP5", "REPS1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOG", "RHOT1", "RHOT2", "RIPK1", "RNASEH2A", "RNF14", "RNH1", "RNPS1", "ROCK1", "RPA1", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL18", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL38", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS26", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRM1", "RRM2", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "S100A11", "SAE1", "SALL2", "SAP18", "SAP30BP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SBNO1", "SCAF4", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCFD1", "SCML2", "SCO1", "SCO2", "SCPEP1", "SCYL2", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC13", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24C", "SEC31A", "SEC61A1", "SEC63", "SEH1L", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B3", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SHMT2", "SIN3A", "SIRT1", "SIRT2", "SKP1", "SLC12A2", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC2A1", "SLC30A7", "SLC35B2", "SLC35F2", "SLC38A1", "SLC3A2", "SLC7A1", "SLC7A5", "SLC9A6", "SLK", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMN1*", "SMYD3", "SNAP23", "SNAP29", "SND1", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SOD2", "SORD", "SORT1", "SPAG9", "SPCS2", "SPCS3", "SPTLC1", "SPTLC2", "SQLE", "SREK1", "SRM", "SRP14", "SRP54", "SRP68", "SRP9", "SRPK1", "SRPRA", "SRRM1", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "STAG1", "STAG2", "STAT1", "STAT3", "STOML2", "STRBP", "STT3A", "STT3B", "STX12", "STX18", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUCLA2", "SUCLG2", "SUGP1", "SUGP2", "SUN1", "SUN2", "SUPT16H", "SUPT6H", "SURF4", "SURF6", "SUZ12", "SV2A", "SWAP70", "SYNCRIP", "SYNGR2", "TAB1", "TAF15", "TAF2", "TAF6L", "TAGLN2", "TAOK1", "TARS", "TARS2", "TBC1D10B", "TBC1D15", "TBC1D4", "TBC1D8B", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBK1", "TCEA1", "TCERG1", "TCF20", "TCP1", "TECR", "TES", "TFIP11", "TFRC", "TGOLN2", "THOC1", "THOC2", "THOC3", "THOP1", "THRAP3", "TJP1", "TK1", "TKT", "TM9SF2", "TM9SF3", "TM9SF4", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM115", "TMEM259", "TMEM97", "TMOD3", "TMPO", "TNPO1", "TNPO3", "TOMM20", "TOMM40", "TOP1", "TP53", "TP53BP1", "TP53BP2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRAP1", "TRAPPC4", "TRIP4", "TRMT6", "TROVE2", "TRUB1", "TSFM", "TSG101", "TSPYL1", "TST", "TSTA3", "TTLL4", "TTYH3", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC9", "TXNRD1", "TXNRD2", "TYMS", "U2SURP", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2L3", "UBE4A", "UCHL5", "UGGT1", "UNC119", "UNC119B", "UPF1", "UPF2", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "USO1", "USP10", "USP11", "USP14", "USP19", "USP28", "USP33", "USP36", "USP39", "USP47", "USP5", "USP7", "USP8", "UTP11", "UTP14A", "UTP3", "UTP6", "VAMP7", "VAPA", "VAPB", "VBP1", "VMP1", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4A", "VPS4B", "VRK1", "VRK3", "WARS", "WDHD1", "WDR1", "WDR33", "WDR82", "WIZ", "WNK1", "XAB2", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC5", "XRCC6", "YARS", "YARS2", "YEATS2", "YLPM1", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBTB10", "ZC3H11A", "ZC3H15", "ZC3H7A", "ZFR", "ZMPSTE24", "ZMYM4", "ZNF207", "ZW10", "ZYX"], "leading_proteins": ["ABCB1", "ACP2", "ACP6", "AHCYL1", "ANP32A", "AP3M1", "AP3S1", "APLP2", "APOBEC3C", "APOL2", "ATP2A2", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1C1", "AUP1", "BAG6", "BAIAP2", "CALU", "CARM1", "CBX1", "CBX5", "CDC37", "CDK2", "CIRBP", "CLUH", "COMT", "CSNK2A2", "CTCF", "CTPS1", "CTSA", "CTSB", "CYB5B", "CYB5D2", "CYP51A1", "DCPS", "DHCR24", "DHFR", "DPH5", "ECE1", "EDC4", "EIF3L", "EIF4B", "EIF5", "ELOC", "ERAP1", "ERAP2", "EWSR1", "FN3KRP", "FNTB", "FOXRED1", "FUBP3", "FUS", "GAA", "GGH", "GLB1", "GLB1L2", "GM2A", "GPX8", "HDAC2", "HEXA", "HM13", "HNRNPK", "IFNGR1", "IGBP1", "KDM1B", "KHDRBS1", "KHDRBS3", "KHSRP", "KPNA1", "KPNA3", "KPNA4", "KPNA6", "LBR", "LNPEP", "MAP2K4", "MCL1", "MFSD3", "MIA2", "MPV17L2", "MSMO1", "MTCH2", "MTMR6", "MTOR", "MYL6", "MYL6B", "NAMPT", "NAP1L1", "NAP1L4", "NDUFB9", "NDUFS2", "NLN", "NPEPPS", "NSD2", "NSUN2", "NT5C3B", "NT5DC1", "NTMT1", "NUCB2", "NUP107", "NUP37", "OCIAD1", "OLA1", "ORC3", "OTUB1", "P3H1", "P3H4", "PANK4", "PDCD5", "PDE6D", "PEBP1", "PECR", "PGRMC2", "PITRM1", "PLA2G15", "PLBD2", "PLD6", "PMPCA", "POGZ", "PPP1CA", "PPP2R1A", "PPP2R1B", "PPT1", "PPT2", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRKAA1", "PRKDC", "PRMT1", "PTGES2", "PTGR1", "PTPRF", "PUM1", "RABGGTA", "RBM14", "RBM3", "RBM4", "RBMX", "RCN2", "REPS1", "RPRD1A", "RPRD1B", "SALL2", "SCARB1", "SCARB2", "SCPEP1", "SDHB", "SEC13", "SEC23B", "SET", "SETD2", "SHMT2", "SIRT2", "SLC16A1", "SLC25A10", "SLC25A15", "SLC25A20", "SLC25A26", "SLC25A32", "SLC35F2", "SLC7A5", "SMN1*", "SMYD3", "SRSF9", "SSR1", "STX18", "SURF4", "SV2A", "TAF15", "TAOK1", "TBC1D9B", "TGOLN2", "THOP1", "TM9SF3", "TMEM97", "TNPO1", "TPP1", "TRA2B", "TUBB", "TUBB2B", "TXLNA", "TXLNG", "TXNDC12", "UNC119B", "USP28", "USP33", "USP47", "WIZ", "ZADH2", "ZC3H15", "ZMPSTE24", "ZMYM4"]} \ No newline at end of file diff --git a/pharos_protein_category/advanced/idx2term.json b/pharos_protein_category/advanced/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..c2c9a89814544d67cab453c74790749979179bf3 --- /dev/null +++ b/pharos_protein_category/advanced/idx2term.json @@ -0,0 +1 @@ +{"0": "Tclin"} \ No newline at end of file diff --git a/pharos_protein_category/advanced/plot_0.png b/pharos_protein_category/advanced/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..74e77ff7df329e23add5d2d74e5d0fe791e7a570 --- /dev/null +++ b/pharos_protein_category/advanced/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:f4bb7e5afe9e3f8b6bb4d7fcfe3aa3ab84011125dc8011d0f653a906e3bde962 +size 186717 diff --git a/pharos_protein_category/basic/idx2term.json b/pharos_protein_category/basic/idx2term.json new file mode 100644 index 0000000000000000000000000000000000000000..46402b03aea9bb0d0449f9e17c5a5647524a9b9c --- /dev/null +++ b/pharos_protein_category/basic/idx2term.json @@ -0,0 +1 @@ +{"0": "Tclin", "1": "Tchem"} \ No newline at end of file diff --git a/pharos_protein_category/basic/plot_0.png b/pharos_protein_category/basic/plot_0.png new file mode 100644 index 0000000000000000000000000000000000000000..bd1133ad2fa8b668fc6930c0ddf1658192e4f38f --- /dev/null +++ b/pharos_protein_category/basic/plot_0.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:3f7897c5b18e53e14f966906152d205ccbec40990f7cc6ea25492bed3ca153fc +size 133200 diff --git a/pharos_protein_category/basic/plot_1.png b/pharos_protein_category/basic/plot_1.png new file mode 100644 index 0000000000000000000000000000000000000000..cc446d4b94b6ebb5b6510e625dba4c7dbb50be19 --- /dev/null +++ b/pharos_protein_category/basic/plot_1.png @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:d132ca477aa6bbb95c9fc1e4ecf6a56fac5075546051a462653be96af95df683 +size 131665 diff --git a/pharos_protein_category/consensus.joblib b/pharos_protein_category/consensus.joblib new file mode 100644 index 0000000000000000000000000000000000000000..8578a84dd21199fd16c2cc1e9e03bb53c2c1cfa4 --- /dev/null +++ b/pharos_protein_category/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:4113d1ee7f45cc0641dd4ed1b8de8c5e4bdc7d5869da5f45538e7263934a5cad +size 71073 diff --git a/pharos_protein_category/df_merge.tsv b/pharos_protein_category/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..6b87939f4aefd28e547f9bdda35c9e83374c59bf --- /dev/null +++ b/pharos_protein_category/df_merge.tsv @@ -0,0 +1,2 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Tclin 22 74 2.2410516621576337 0.0250227287732103 19.366504854368937 86.39077669902913 0.9399778874953114 0.4805096456956057 6.659845213621253 7.009024167820235 0.9745051203556824 0.3806460486794667 0.0170851649050946 0.0919373334690581 0.0596580279202176 0.0834194084062932 0.0009611023467362 diff --git a/pharos_protein_category/metrics.json b/pharos_protein_category/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..8fbb19de08ac6559008e710009d3f614e8c60c2a --- /dev/null +++ b/pharos_protein_category/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2812, + "annotations_size": 4, + "title": "Average number of proteins per term", + "value": 702.75 +} \ No newline at end of file diff --git a/pharos_protein_category/paths.json b/pharos_protein_category/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..53c6982b608987fabd9de47a2576f9098ff0c6ea --- /dev/null +++ b/pharos_protein_category/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/pharos_protein_category/fragment/C428/C428_val_log2fc"} \ No newline at end of file diff --git a/pharos_protein_category/result.tsv b/pharos_protein_category/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..99635543622e051d1660c5c2d613cfbd443aa94b --- /dev/null +++ b/pharos_protein_category/result.tsv @@ -0,0 +1,3 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Tclin 0.4418041103648912 2.2410516621576337 0.0250227287732103 0.0963963719346338 0.0500454575464206 74 P68371,P21964,P49721,O43676,O43924,P06280,P10253,P62942,P48735,P31350,P28074,P03886,Q8N183,Q92769,P20618,Q02750,O75306,P00374,P07437,Q9BVA1,Q9Y6M9,Q7L0J3 22 +Tchem 0.382299658304031 1.8017918565423907 0.0715781594519631 0.2570126943711254 0.0954375459359508 281 P30536,P07099,O75874,Q13432,P62136,P14174,P55786,P29375,Q9BTY2,Q5BJF2,P42785,Q13126,P45880,P48449,P08236,P06865,Q6P179,Q03164,Q9UIQ6,P53985,Q5JRX3,O60502,P30519,P07858,P13674,P16278,P55899,P09960,Q8WTV0,P49356,P43490,P10619,Q16850,P45985,P11717,O60725,O43865,P78417,Q9H773,Q92820,O15270,P09601,Q99523,P08183,P42892,P04062,Q86X55,Q96K76,Q9BYW2,P35790,Q06124,Q7L7X3,P30419,Q07820,P42858,P31751,O14976,Q15904,P23786,Q9H7B4,P42356,O14936,Q9H7Z7 63 diff --git a/pharos_protein_category/selections.json b/pharos_protein_category/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..17556445ab4138bcad83108a1dcc487ac2784fd6 --- /dev/null +++ b/pharos_protein_category/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Tbio", "Tchem", "Tclin", "Tdark"], "available_proteins": ["AAAS", "AACS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABRAXAS2", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AGTRAP", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK6", "AKAP1", "AKAP12", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG5", "ALKBH5", "ALYREF", "AMOT", "AMPD2", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOBEC3C", "APOL2", "APOOL", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6", "ARL6IP1", "ARL6IP5", "ARL8A", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ASAH1", "ASCC1", "ASCC3", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATG9A", "ATIC", "ATP11C", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "B3GALT6", "B4GAT1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS2", "BCCIP", "BCL2L13", "BCLAF1", "BCOR", "BCS1L", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRD1", "BRD2", "BRI3BP", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C11orf58", "C12orf43", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C2orf49", "CAB39", "CACNA2D1", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASK", "CAST", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC137", "CCDC22", "CCDC43", "CCDC47", "CCDC58", "CCDC6", "CCDC8", "CCDC86", "CCDC93", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD47", "CDC123", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA2", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDKAL1", "CDKN2AIP", "CDS2", "CDV3", "CEBPZ", "CELF1", "CENPF", "CENPI", "CEP170", "CEP44", "CEP55", "CEPT1", "CERS2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD7", "CHEK2", "CHERP", "CHID1", "CHKA", "CHMP2A", "CHMP2B", "CHMP4B", "CHMP5", "CHMP6", "CHMP7", "CHORDC1", "CHTF18", "CHTOP", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CKAP2", "CKAP2L", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG2", "COG4", "COG7", "COIL", "COLEC12", "COLGALT1", "COMMD4", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7B", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX15", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7A2", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWC22", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBR1", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCXR", "DDA1", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX27", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS13", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX34", "DHX35", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DIP2B", "DIS3", "DKC1", "DLAT", "DLD", "DLGAP5", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC17", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOCK7", "DOHH", "DPH5", "DPM1", "DPP3", "DPYSL2", "DR1", "DRG1", "DRG2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "DYNLL2", "DYNLT1", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC4", "EDF1", "EDRF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMOD2", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERCC6L", "ERG28", "ERGIC1", "ERGIC2", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESS2", "ESYT1", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC5", "EXOC6", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120A", "FAM162A", "FAM177A1", "FAM208A", "FAM208B", "FAM213A", "FAM49B", "FAM8A1", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD5", "FAU", "FBL", "FBXO7", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP10", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNDC3A", "FNTA", "FNTB", "FOXRED1", "FRG1", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "FYTTD1", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDAP2", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GGH", "GHDC", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLB1L2", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGB1", "GOLIM4", "GOLM1", "GORASP2", "GOT1", "GOT2", "GPAA1", "GPATCH4", "GPD1L", "GPD2", "GPHN", "GPI", "GPR107", "GPR108", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSDME", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GTF2F1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS5", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HEBP2", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HEXIM1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGA2", "HMGB1", "HMGB2", "HMGB3", "HMGCR", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPF1", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA12A", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPB11", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICE1", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFIT5", "IFNGR1", "IFT27", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INCENP", "INTS1", "INTS13", "INTS14", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQSEC1", "IRF2BPL", "IRS4", "ISOC1", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITM2B", "ITPA", "ITPK1", "IVD", "IWS1", "JAGN1", "JMJD6", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0100", "KIAA0319L", "KIAA0368", "KIAA1147", "KIAA2013", "KIF11", "KIF14", "KIF18A", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "LAMP1", "LAMTOR1", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LGALS3BP", "LIG3", "LIMA1", "LIN28B", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRSAM1", "LRWD1", "LSM12", "LSM14A", "LSM2", "LSM4", "LSM6", "LSM7", "LSM8", "LSS", "LTA4H", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAK16", "MANBA", "MANF", "MAP1B", "MAP2K1", "MAP2K4", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKS", "MARCKSL1", "MARS", "MAT2A", "MAT2B", "MATR3", "MAU2", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MDC1", "MDH1", "MDH2", "MDN1", "ME2", "MECP2", "MED24", "MED4", "METTL13", "METTL16", "MFAP1", "MFF", "MFN1", "MFN2", "MFSD10", "MFSD14B", "MFSD3", "MFSD5", "MFSD8", "MGAT1", "MGEA5", "MGME1", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MIPEP", "MKI67", "MKRN2", "MLEC", "MMADHC", "MMS19", "MOB4", "MOGS", "MORC2", "MORF4L1", "MORF4L2", "MOV10", "MPDU1", "MPG", "MPHOSPH10", "MPHOSPH8", "MPI", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL45", "MRPL47", "MRPL51", "MRPL53", "MRPL9", "MRPS11", "MRPS15", "MRPS17", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTHFD1", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MUT", "MXRA7", "MYADM", "MYBBP1A", "MYCBP", "MYCBP2", "MYDGF", "MYEF2", "MYG1", "MYH10", "MYH9", "MYL6", "MYL6B", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NAE1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NCAPD2", "NCAPD3", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "ND1", "NDC1", "NDRG3", "NDUFA10", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV2", "NECAP2", "NEDD4L", "NEFM", "NEK9", "NELFB", "NELFCD", "NELFE", "NENF", "NF1", "NFATC2IP", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIPSNAP2", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NOVA2", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUB1", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "OXCT1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PAPSS2", "PARK7", "PARN", "PARP1", "PAWR", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDZD11", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF3", "PHF5A", "PHF6", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PIBF1", "PICALM", "PIGK", "PIGS", "PIGT", "PIK3C2A", "PIK3R4", "PIN4", "PIR", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLRG1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2A", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "PON2", "POP1", "POP7", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL4", "PPM1F", "PPM1G", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA1", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38A", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PRSS3", "PRTFDC1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSPC1", "PTBP1", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS7", "PWP1", "PWP2", "PWWP2A", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "PYM1", "QARS", "QKI", "QPRT", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB23", "RAB2A", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "REEP5", "REPS1", "RER1", "RETREG3", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIDA", "RIF1", "RIPK1", "RMDN1", "RNASEH2A", "RNASEH2B", "RNASET2", "RNF14", "RNF2", "RNF20", "RNF219", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK1", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RSU1", "RTCB", "RTFDC1", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SBNO1", "SCAF1", "SCAF11", "SCAF4", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SCYL2", "SDAD1", "SDE2", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC13", "SEC14L2", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SELENBP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHMT2", "SHTN1", "SIGMAR1", "SIL1", "SIN3A", "SIRT1", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC2A1", "SLC30A7", "SLC35A4", "SLC35B2", "SLC35F2", "SLC38A1", "SLC3A2", "SLC7A1", "SLC7A5", "SLC9A3R1", "SLC9A6", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SORT1", "SPAG5", "SPAG9", "SPART", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPECC1", "SPECC1L", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRFBP1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STIP1", "STMN1", "STOML2", "STRAP", "STRBP", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SV2A", "SWAP70", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TAB1", "TACC3", "TAF15", "TAF2", "TAF5", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TAOK1", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D15", "TBC1D4", "TBC1D8B", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBK1", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCF25", "TCOF1", "TCP1", "TECR", "TELO2", "TERF2IP", "TES", "TEX10", "TFAM", "TFB1M", "TFG", "TFIP11", "TFRC", "TGOLN2", "THEM6", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "TIA1", "TIAL1", "TIGAR", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TJP1", "TK1", "TKT", "TLN1", "TM9SF2", "TM9SF3", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM115", "TMEM126A", "TMEM14C", "TMEM167A", "TMEM192", "TMEM199", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM230", "TMEM259", "TMEM33", "TMEM43", "TMEM65", "TMEM97", "TMOD3", "TMPO", "TMPO", "TMPPE", "TMTC3", "TMX1", "TMX2", "TMX4", "TNPO1", "TNPO3", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOR1AIP2", "TOX4", "TP53", "TP53BP1", "TP53BP2", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPRKB", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC4", "TRAPPC5", "TRAPPC8", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMT11", "TRMT112", "TRMT1L", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSNAX", "TSPAN6", "TSPO", "TSPYL1", "TSR1", "TSR3", "TST", "TSTA3", "TTC1", "TTC19", "TTC21B", "TTC26", "TTC27", "TTC37", "TTC38", "TTC4", "TTLL12", "TTLL4", "TTYH3", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNL4A", "TXNRD1", "TXNRD2", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBFD1", "UBL5", "UBLCP1", 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a/protein_atlas_biological_process/df_merge.tsv b/protein_atlas_biological_process/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..b33209b0b4aa4b8e884ef83212d6c9553bb0ddae --- /dev/null +++ b/protein_atlas_biological_process/df_merge.tsv @@ -0,0 +1,5 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Transport 72 445 2.8026188885901626 0.0050689529739067 127.39320388349516 491.7621359223301 1.4832290368286314 0.5289485259644714 40.31460927260851 50.077723312236 2.248556521823017 0.4543981544818752 3.133756002367593e-05 6.970748789870192e-06 0.0007734144438178 5.71582899142862e-07 9.746321198994589e-07 +Immunity 26 75 2.4036899308515403 0.0162305333251866 17.820388349514563 76.64077669902913 0.3712215805873788 0.6852303500560589 6.509274327939261 7.523560880911209 0.7685662507868273 0.3361567579513101 0.8042317176755015 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"annotations_size": 166, + "title": "Average number of proteins per term", + "value": 28.1144578313253 +} \ No newline at end of file diff --git a/protein_atlas_biological_process/paths.json b/protein_atlas_biological_process/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..bd7f0d9c2c31288165df78e6a872fb74532dceb7 --- /dev/null +++ b/protein_atlas_biological_process/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_biological_process/fragment/C428/C428_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_biological_process/result.tsv b/protein_atlas_biological_process/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..5e2bd3de9f4551b2835cd071a8fcad6ada44bec8 --- /dev/null +++ b/protein_atlas_biological_process/result.tsv @@ -0,0 +1,47 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Transport 0.3377673843832657 2.8026188885901626 0.0050689529739067 0.5698348410930099 0.13634972499564 445 P55735,A6NIH7,Q7L0J3,Q96CU9,Q9NS69,Q9Y282,Q99595,O60830,Q70HW3,Q8TD16,P21796,Q9C0H2,Q9H1E5,P45880,O95197,Q96ES6,Q8NHS3,P36543,P53985,O75964,Q9BQE5,P57740,P22626,O00505,O43676,Q92973,Q9Y487,O00629,P52294,Q93050,Q9BZF1,P46379,O43823,Q92945,Q8IUD2,Q8IXU6,Q5SR56,O95721,Q15629,Q6P4Q7,O60684,Q9UBX3,Q9H2D1,Q9Y4C2,P21912,Q92783,P11717,O00461,Q13505,Q14847,O43772,Q9P2W9,Q9Y619,O15118,P08183,Q9BW83,Q8NE01,Q9HD20,P31751,O14964,Q8N4H5,Q8NFH4,Q9Y6C9,Q15437,Q15904,O75306,P47985,Q6DKK2,Q92572,Q9Y6M9,Q9Y2T2,O43169 72 +Immunity 0.4538332573049401 2.4036899308515403 0.0162305333251866 0.9338858669163248 0.1626778502361497 75 Q9NRW3,Q96FW1,P14174,P04083,O00743,P43243,Q6P179,P04439,O00584,P01889,Q9NZ08,P46379,O43823,P10321,Q8WXW3,O75179,Q9NUD5,Q8IV08,Q9BYW2,Q13501,P17931,O94992,P17812,Q9UQ84,Q8IXJ6,Q96PK6 26 +Translocation 0.5007904655859136 2.2697485410251343 0.0232228444002509 0.979767385766814 0.2141662316912028 45 P55735,Q9BW27,Q9BTX1,Q9NS69,Q99567,Q99595,O60830,Q8TD16,Q8NFH4,Q15629,P57740,Q12769 12 +Adaptive immunity 0.6531159431416286 2.0306870387956977 0.0422867519837815 0.9992324756241736 0.2924833678878221 13 P10321,Q96FW1,P01889,P04083,Q6P179,P04439 6 +Sphingolipid metabolism 0.7089612918611855 1.9083908462062884 0.0563407190750724 0.999934033144345 0.3114405694889876 9 O15270,Q06136,P07602,P04062 4 +Apoptosis 0.3845093082051256 1.8881780537186368 0.0590020510355149 0.999958721837856 0.3114405694889876 110 Q9H2J4,O75940,P21796,O60216,O95197,Q03164,Q16539,Q13564,Q96A26,Q96FV9,Q9BZZ5,O95831,O95470,P46379,O14737,P31483,Q9UHX1,Q53EL6,P61289,Q8IXM3,P45985,Q9NR28,P09601,Q9NXR7,P52756,Q9H8M7,Q8WYA6,Q13501,Q7L7X3,O75832,Q07820,P42858,P31751,Q96IZ0,P21127,Q01085 36 +Sterol metabolism 0.5294678278949857 1.8421259206376603 0.0654567330893856 0.999986832523922 0.329267202813273 22 P61916,Q14739,Q16850,Q9UKR5,Q15392,O15118,P04062,Q15800 8 +Cholesterol metabolism 0.5349336028054511 1.801598891450814 0.0716085358170075 0.999995600847243 0.3396290555892358 21 Q16850,Q15392,O15118,P04062,Q15800 5 +Glyoxylate bypass 0.95266903914591 1.7613439310148524 0.0781802087577281 0.9999986471779858 0.3507544501022397 2 P48735 1 +Steroid metabolism 0.5005124481604594 1.7146450998566405 0.0864103147162109 0.9999996947208508 0.3518302957415826 23 P61916,Q14739,Q16850,Q9UKR5,Q15392,O15118,P04062,Q15800 8 +Respiratory chain 0.4725339920160644 1.703553218706914 0.0884645875630039 0.99999978990848 0.3518302957415826 28 Q96CU9,O43676,O75306,P47985,Q6DKK2 5 +Electron transport 0.4445884768191511 1.663535840878809 0.0962052226737562 0.999999948997514 0.359808067900593 41 P21912,Q96CU9,O43676,Q9H1E5,O75306,P47985,Q6DKK2,O43169 8 +Sensory transduction 0.682114517276671 1.6050847955177736 0.1084751448847662 0.999999994725836 0.3635177513581994 7 P50897,O43924,Q6P4Q7 3 +Vision 0.682114517276671 1.6050847955177736 0.1084751448847662 0.999999994725836 0.3635177513581994 7 P50897,O43924,Q6P4Q7 3 +Spermatogenesis 0.4958045680454679 1.60047477462558 0.1094932986018673 0.9999999956371138 0.3635177513581994 22 Q9P0K7,Q8N2A8,P46379,Q08J23,Q14671,Q9BW83 6 +Cholesterol biosynthesis 0.534912058337466 1.359088752905643 0.174118466373057 0.9999999999999838 0.4738305806217618 13 Q15800,Q15392,Q16850 3 +Steroid biosynthesis 0.4871869132888966 1.336795883486651 0.1812892732760771 0.9999999999999962 0.4833667284347502 19 P48449,Q15392,Q16850,Q15800 4 +Sterol biosynthesis 0.5171534013416558 1.3302181403002458 0.1834464089842726 0.9999999999999976 0.4833667284347502 14 Q14739,Q16850,Q9UKR5,Q15392,Q15800 5 +Ion transport 0.3945173773461886 1.2919180507892594 0.1963855258566382 0.9999999999999998 0.50153841988003 47 Q8NE01,Q9Y487,Q93050,P21796,Q9C0H2,P45880,Q15904,P36543,O75964,Q6P4Q7 10 +Prostaglandin metabolism 0.8901771322355386 1.2713411186008357 0.2036073201473673 1.0 0.5092781397193339 3 Q9H7Z7 1 +Phospholipid metabolism 0.5217703619902928 1.2153816051303683 0.224220580526558 1.0 0.5394292227160671 12 Q9NPH0,Q99943,P35790,Q8NF37 4 +Innate immunity 0.3628850099108491 1.1660615571735051 0.2435895580891709 1.0 0.5583064726951571 58 P10321,Q9NRW3,O75179,O00584,Q8IXJ6,P14174,P01889,Q9NUD5,O43823,O94992,P04083,O00743,P43243,Q9BYW2,Q96PK6,P17931,P04439 17 +Hydrogen ion transport 0.4614757755060324 1.1612990239744625 0.2455203163057016 1.0 0.5583064726951571 19 Q9Y487,O75964,Q93050,P36543 4 +Host-virus interaction 0.3576456367997354 1.1127526687246232 0.2658146683977305 1.0 0.5883364660536434 230 Q15369,Q01105,Q9NRW3,P62136,P21796,P49721,O95197,Q9UPU5,P22626,O60502,P04439,P39687,O00505,Q8WTV0,P25788,Q92973,O00629,P52294,P01889,P28072,Q15629,O60684,P49720,O43765,P10321,O60506,O75179,P28074,Q99436,O15118,P61978,Q14108,Q86X55,Q9BYW2,Q8TAE8,Q9Y679,Q06787,P20618,Q9ULX6,P28070,O75525,Q9Y624,Q9Y2T2 43 +Glycogen biosynthesis 0.7378725344832592 1.041613544989492 0.297590886282292 1.0 0.6399149936092423 4 P35573,P31751 2 +Lipid metabolism 0.3189903411389433 0.9571083731519838 0.3385125577980856 1.0 0.6770251155961713 106 Q15392,Q14914,P42126,P48449,O15254,Q96N66,Q15800,Q9BY49,Q96G23,P09960,P61916,Q8N2A8,Q8NF37,Q9UKR5,Q9NPH0,P51648,Q709F0,P37268,Q8NHP8,Q16850,Q15067,O15270,O15118,Q8NCC3,P04062,P35790,Q14739,P07602,Q9Y217,Q16836,Q06136,Q99943,P23786,Q9H7Z7,P17900 35 +Glycogen metabolism 0.6209101080918397 0.9426672936562324 0.345851107525061 1.0 0.6834676648709539 5 P31751 1 +Angiogenesis 0.5240474817065277 0.9217295402905884 0.3566696679879568 1.0 0.6965548810117745 8 Q9H2J4,Q13685 2 +Phospholipid biosynthesis 0.4773471196050632 0.9114463917628666 0.3620602194049533 1.0 0.6988604235025844 11 Q99943,P35790,Q8NF37 3 +Peroxisome biogenesis 0.727758007117435 0.8471842791432342 0.3968924147036712 1.0 0.7412331647250621 2 P40855 1 +Biological rhythms 0.3402353774478781 0.6814341106666708 0.4955968453095876 1.0 0.7985190121945426 41 O14744,Q14103,Q16531,O00429,Q92769,Q00839,P17844,P29375,Q13131,P43490,Q96ST3,Q03164,Q05086,Q93009,P42345 15 +Inflammatory response 0.4445359471211916 0.6582170682428816 0.510398658715487 1.0 0.7985190121945426 10 Q8IV08,P14174 2 +Cilium biogenesis/degradation 0.3953619060208898 0.6339996178065644 0.5260810715379576 1.0 0.7985190121945426 16 A6NIH7,O95684 2 +Differentiation 0.3089849332558714 0.629550471300065 0.528988737195724 1.0 0.7985190121945426 76 Q99829,O60869,Q08J23,O75312,Q9P0K7,Q8N2A8,P46379,Q14671,Q13685,P51114,Q96PU8,Q4G0J3,Q99523,Q9BYW2,Q9BW83,Q9BWF3,Q13501,P17931,Q07820,Q9UJX6,Q8IXJ6 21 +GPI-anchor biosynthesis 0.6085648404127405 0.5699385685010678 0.568719364651884 1.0 0.7985190121945426 4 Q96S52,O43292 2 +ER-Golgi transport 0.3057979978012418 0.4144450309470232 0.6785482160454694 1.0 0.8799922176839682 47 P55735,O95197,Q9Y282,Q15437 4 +Transcription termination 0.6024911032028424 0.4063397732017131 0.6844929653771901 1.0 0.8808204050590198 2 Q9H0D6 1 +Tricarboxylic acid cycle 0.3343483076017027 0.3311900047347277 0.7405009696726048 1.0 0.9312360679216092 19 P48735,O75874 2 +Notch signaling pathway 0.5099759755442896 0.2705421160568336 0.786743220535628 1.0 0.954878810140844 4 Q92542 1 +Neurogenesis 0.2930944351176099 0.2688272370838894 0.7880626324656363 1.0 0.954878810140844 41 Q9BVA1,Q7L576,Q9NQC3,Q06787,Q16637,Q9UJX6,Q969G3,Q8WUJ1,Q9Y263,P55209,Q9H9T3,Q8IXJ6 12 +One-carbon metabolism 0.3201113035514921 0.0926921243730782 0.9261481539144194 1.0 1.0 9 O43865,P34897,P00374 3 +Meiosis 0.2900955287097805 0.0926783121956922 0.9261591272028468 1.0 1.0 16 Q9UQ84 1 +Glutathione biosynthesis 0.4519572953736599 0.0898567596664417 0.9284010428781956 1.0 1.0 2 P48507 1 +mRNA transport 0.2626802780286343 0.0824431398357367 0.9342943321591082 1.0 1.0 66 P55735,Q9BW27,Q06787,Q96ST2,Q96PU8,Q99567,Q9BTX1,Q96FV9,Q8TD16,Q8NFH4,Q92945,P57740,Q12769,P22626 14 +Cell shape 0.3455646597791159 0.0558997741953955 0.955421650716278 1.0 1.0 5 P35580,Q7L576,Q96AC1,P35579 4 +Exocytosis 0.2913222913377248 0.0513534684747911 0.9590438625933252 1.0 1.0 11 O00471,Q9UPT5,P11233 3 diff --git a/protein_atlas_biological_process/selections.json b/protein_atlas_biological_process/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..ee747eff9382135699c119de3b3307a0efdfce50 --- /dev/null +++ b/protein_atlas_biological_process/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["ATP synthesis", "Adaptive immunity", "Amino-acid biosynthesis", "Amino-acid transport", "Angiogenesis", "Antiport", "Antiviral defense", "Apoptosis", "Arginine metabolism", "Aromatic hydrocarbons catabolism", "Asparagine biosynthesis", "Autophagy", "B-cell activation", "Behavior", "Biological rhythms", "Biomineralization", "Branched-chain amino acid catabolism", "Calcium transport", "Carbohydrate metabolism", "Catecholamine metabolism", "Cell adhesion", "Cell cycle", "Cell division", "Cell shape", "Chemotaxis", "Cholesterol biosynthesis", "Cholesterol metabolism", "Chromosome partition", "Cilium biogenesis/degradation", "Coenzyme A biosynthesis", "Collagen degradation", "Complement pathway", "Cytoplasmic inwards viral transport", "DNA condensation", "DNA damage", "DNA excision", "DNA recombination", "DNA repair", "DNA replication", "DNA synthesis", "Detoxification", "Differentiation", "Digestion", "ER-Golgi transport", "Electron transport", "Endocytosis", "Erythrocyte maturation", "Exocytosis", "Fatty acid biosynthesis", "Fatty acid metabolism", "Fertilization", "GMP biosynthesis", "GPI-anchor biosynthesis", "Galactose metabolism", "Gastrulation", "Gluconate utilization", "Gluconeogenesis", "Glucose metabolism", "Glutathione biosynthesis", "Glycogen biosynthesis", "Glycogen metabolism", "Glycolysis", "Glyoxylate bypass", "Growth arrest", "Growth regulation", "Hearing", "Heme biosynthesis", "Host-virus interaction", "Hydrogen ion transport", "Hypusine biosynthesis", "Immunity", "Inflammatory response", "Inhibition of host STAT1 by virus", "Inhibition of host STAT2 by virus", "Inhibition of host innate immune response by virus", "Inhibition of host interferon signaling pathway by virus", "Innate immunity", "Inositol biosynthesis", "Ion transport", "Isoprene biosynthesis", "Leukotriene biosynthesis", "Lipid biosynthesis", "Lipid degradation", "Lipid metabolism", "Lipid transport", "Meiosis", "Methionine biosynthesis", "Methotrexate resistance", "Microtubular inwards viral transport", "Mitosis", "Molybdenum cofactor biosynthesis", "Myogenesis", "Necrosis", "Neurogenesis", "Neurotransmitter degradation", "Neurotransmitter transport", "Nonsense-mediated mRNA decay", "Notch signaling pathway", "Nucleotide biosynthesis", "Nucleotide metabolism", "One-carbon metabolism", "Oogenesis", "Osteogenesis", "Pentose shunt", "Peroxisome biogenesis", "Phagocytosis", "Phenylalanine catabolism", "Phospholipid biosynthesis", "Phospholipid metabolism", "Plasminogen activation", "Polyamine biosynthesis", "Porphyrin biosynthesis", "Potassium transport", "Proline biosynthesis", "Proline metabolism", "Prostaglandin biosynthesis", "Prostaglandin metabolism", "Protein biosynthesis", "Protein transport", "Purine biosynthesis", "Purine salvage", "Pyridine nucleotide biosynthesis", "Pyrimidine biosynthesis", "RNA-mediated gene silencing", "Respiratory chain", "Ribosome biogenesis", "Sensory transduction", "Serine biosynthesis", "Sodium transport", "Sodium/potassium transport", "Spermatogenesis", "Spermidine biosynthesis", "Sphingolipid metabolism", "Steroid biosynthesis", "Steroid metabolism", "Sterol biosynthesis", "Sterol metabolism", "Stress response", "Sugar transport", "Symport", "Tetrahydrobiopterin biosynthesis", "Transcription", "Transcription regulation", "Transcription termination", "Translation regulation", "Translocation", "Transport", "Tricarboxylic acid cycle", "Tyrosine catabolism", "Ubl conjugation pathway", "Unfolded protein response", "Urea cycle", "Viral RNA replication", "Viral immunoevasion", "Viral penetration into host nucleus", "Virus entry into host cell", "Vision", "Wnt signaling pathway", "Xylose metabolism", "Zinc transport", "mRNA capping", "mRNA processing", "mRNA splicing", "mRNA transport", "rRNA processing", "tRNA processing"], "available_proteins": ["AAAS", "AACS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABCF3", "ABHD12", "ABRAXAS2", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT7", "ACOT8", "ACOX1", "ACOX3", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN4", "ACTR3", "ADAR", "ADI1", "ADK", "ADNP", "ADPGK", "ADSL", "ADSS", "AFDN", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AKAP8", "AKAP8L", "AKT2", "ALDH18A1", "ALDH3A2", "ALDH4A1", "ALDOA", "ALDOC", "ALKBH5", "AMPD2", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC5", "ANAPC7", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANO6", "ANP32A", "ANP32B", "ANXA1", "ANXA11", "ANXA2", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEX1", "API5", "APOBEC3C", "APOL2", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP2", "ARG2", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL2", "ARL3", "ARL6", "ARL6IP1", "ARL8A", "ARMT1", "ASAH1", "ASCC1", "ASCC3", "ASNA1", "ASNS", "ATAD2", "ATAD5", "ATG9A", "ATIC", "ATP11C", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "AUP1", "BABAM2", "BAG6", "BANF1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS2", "BCCIP", "BCL2L13", "BCLAF1", "BCOR", "BICD2", "BIRC6", "BMS1", "BNIP1", "BOP1", "BPTF", "BRD1", "BRD2", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C12orf43", "C1QBP", "CACNA2D1", "CACYBP", "CAD", "CAMK2G", "CAND1", "CANX", "CAPRIN1", "CARM1", "CARS", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC22", "CCDC86", "CCDC93", "CCNB1", "CCNB2", "CD2AP", "CD2BP2", "CD47", "CDC123", "CDC16", "CDC23", "CDC27", "CDC42", "CDC5L", "CDC73", "CDCA2", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDKAL1", "CDS2", "CEBPZ", "CELF1", "CENPF", "CEP55", "CEPT1", "CERS2", "CFL1", "CHAF1A", "CHAF1B", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD7", "CHEK2", "CHID1", "CHKA", "CHMP2A", "CHMP2B", "CHMP4B", "CHMP5", "CHMP6", "CHMP7", "CHORDC1", "CHTF18", "CHTOP", "CIAPIN1", "CIRBP", "CISD2", "CKAP2", "CKAP5", "CLASP1", "CLCN3", "CLIC1", "CLIC4", "CLINT1", "CLPTM1", "CLPTM1L", "CLTA", "CLTC", "CMPK1", "CMTR1", "CNNM3", "CNNM4", "CNOT1", "CNOT7", "CNOT9", "COG2", "COG7", "COMMD4", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS6", "COPS7B", "COPZ1", "COX2", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF7", "CPT2", "CRNKL1", "CS", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTF1", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTR9", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWC15", "CWC22", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBR1", "DCAF1", "DCAF13", "DCAF7", "DCPS", "DCTN1", "DCTN3", "DCUN1D1", "DCXR", "DDA1", "DDB1", "DDRGK1", "DDX1", "DDX17", "DDX20", "DDX21", "DDX23", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX46", "DDX47", "DDX5", "DDX51", "DDX54", "DDX56", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHX15", "DHX16", "DHX29", "DHX30", "DHX35", "DHX36", "DHX38", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIDO1", "DIMT1", "DIP2B", "DIS3", "DKC1", "DLAT", "DLGAP5", "DLST", "DNAAF5", "DNAJA3", "DNAJB1", "DNAJC13", "DNAJC17", "DNAJC2", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOCK7", "DOHH", "DPYSL2", "DR1", "DSG2", "DTYMK", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "DYNLL2", "DYNLT1", "EARS2", "EBNA1BP2", "ECH1", "ECHS1", "ECI1", "EDF1", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELMOD2", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMC4", "EMG1", "EML4", "ENO1", "ENO2", "ENSA", "EPB41", "EPB41L2", "EPB41L3", "EPHX1", "EPHX2", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERCC6L", "ERG28", "ERGIC1", "ERGIC2", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERO1A", "ERP44", "ESF1", "ESS2", "ESYT1", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC5", "EXOC6", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FAF1", "FAF2", "FAH", "FAM162A", "FAM208A", "FANCD2", "FANCI", "FAR1", "FARSA", "FARSB", "FASN", "FASTKD5", "FBL", "FBXO7", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP8", "FLII", "FLNA", "FLNB", "FLOT2", "FMR1", "FOXRED1", "FRG1", "FRYL", "FTSJ3", "FUBP1", "FUBP3", "FXR1", "FYTTD1", "G3BP1", "G3BP2", "G6PD", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCC2", "GCFC2", "GCLM", "GCN1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA2", "GHITM", "GINS2", "GINS3", "GINS4", "GLRX", "GM2A", "GMPS", "GNAI2", "GNAI3", "GNL2", "GNL3L", "GNPDA1", "GOLIM4", "GORASP2", "GOT1", "GOT2", "GPAA1", "GPHN", "GPI", "GRB2", "GRSF1", "GRWD1", "GSDME", "GSPT1", "GSS", "GTF2F1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP10", "GTPBP3", "GTPBP4", "GYG1", "GYS1", "H2AFX", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAUS5", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HELLS", "HEXIM1", "HGS", "HIBADH", "HIBCH", "HINT2", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLTF", "HMBS", "HMCES", "HMGA1", "HMGA2", "HMGB1", "HMGB2", "HMGB3", "HMGCR", "HMGCS1", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH3", "HNRNPK", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HPF1", "HPRT1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPB1", "HSPB11", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICE1", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFIT5", "IFT27", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "ILF2", "ILF3", "ILVBL", "IMP3", "IMP4", "IMPDH2", "INCENP", "INTS13", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITPA", "IVD", "IWS1", "JAGN1", "JMJD6", "JUP", "KARS", "KAT7", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0319L", "KIF11", "KIF18A", "KIF1B", "KIF20A", "KIF23", "KIF2A", "KIF2C", "KIFBP", "KIN", "KLC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRR1", "LAMP1", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LETM1", "LGALS3", "LGALS3BP", "LIG3", "LIMA1", "LIN28B", "LLGL1", "LMAN1", "LMAN2", "LPCAT1", "LPGAT1", "LRP1", "LRPPRC", "LRRC41", "LRSAM1", "LRWD1", "LSM14A", "LSM2", "LSM4", "LSM6", "LSM7", "LSM8", "LSS", "LTA4H", "LUC7L3", "LYAR", "LYPLA1", "M6PR", "MACF1", "MAD2L1", "MAGT1", "MANF", "MAP2K4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARS", "MAT2A", "MAT2B", "MATR3", "MAU2", "MBD3", "MBOAT7", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MDC1", "MDH1", "MDH2", "MECP2", "MED24", "MED4", "MFAP1", "MFN2", "MFSD10", "MFSD14B", "MFSD3", "MFSD5", "MFSD8", "MGEA5", "MGME1", "MIA3", "MICU1", "MID1", "MIF", "MINDY3", "MKI67", "MKRN2", "MLEC", "MMS19", "MOB4", "MORC2", "MORF4L1", "MORF4L2", "MOV10", "MPDU1", "MPG", "MPHOSPH10", "MPHOSPH8", "MRE11", "MRPL41", "MRPS27", "MRTO4", "MSH2", "MSH3", "MSH6", "MSMO1", "MSN", "MTA1", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTHFD1L", "MTHFD2", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTR", "MTX1", "MTX2", "MTX3", "MYBBP1A", "MYCBP", "MYCBP2", "MYDGF", "MYH10", "MYH9", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAE1", "NAMPT", "NAP1L1", "NAPA", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NCAPD2", "NCAPD3", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCKAP1", "NCOA5", "NCSTN", "ND1", "NDC1", "NDUFA10", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA9", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV2", "NECAP2", "NEDD4L", "NEK9", "NELFCD", "NELFE", "NHP2", "NIP7", "NIPBL", "NKRF", "NLE1", "NME1", "NOC2L", "NOL11", "NOL8", "NOL9", "NONO", "NOP14", "NOP2", "NOP56", "NOP58", "NOSIP", "NPC1", "NPC2", "NPLOC4", "NPM1", "NSA2", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NUDC", "NUDCD1", "NUDT21", "NUF2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUTF2", "NVL", "NXF1", "NXN", "OCRL", "OGDH", "OGT", "OPA1", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "PA2G4", "PABPC1", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK1IP1", "PAK2", "PANK4", "PAPOLA", "PARK7", "PARN", "PARP1", "PAWR", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCID2", "PCK2", "PCLAF", "PCM1", "PCNA", "PCNP", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDK3", "PDS5A", "PDS5B", "PECR", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PFAS", "PFKL", "PFKM", "PFKP", "PGAM1", "PGAM5", "PGD", "PGK1", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PHAX", "PHB", "PHB2", "PHF5A", "PHF6", "PHGDH", "PIBF1", "PICALM", "PIGK", "PIGS", "PIGT", "PIK3C2A", "PIR", "PITHD1", "PITPNB", "PKM", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLIN3", "PLK1", "PLRG1", "PNN", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "POP1", "POP7", "PPAT", "PPID", "PPIF", "PPIH", "PPIL1", "PPM1F", "PPOX", "PPP1CA", "PPP1CB", "PPP1R8", "PPP2R1A", "PPP5C", "PPP6C", "PPT1", "PRC1", "PRCC", "PRDX6", "PREB", "PRIM1", "PRIM2", "PRKAA1", "PRKAG1", "PRKCB", "PRKDC", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38A", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRSS3", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA3", "PSMA4", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC3", "PSMD10", "PSMD14", "PSME3", "PSME4", "PSPC1", "PTBP1", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTK7", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PURA", "PUS7", "PWP1", "PYCR1", "PYCR2", "PYGB", "PYGL", "PYM1", "QARS", "QKI", "QPRT", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB23", "RAB2A", "RAB35", "RAB3B", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP2", "RANBP3", "RAPGEF2", "RARS", "RBBP5", "RBBP6", "RBM10", "RBM14", "RBM15", "RBM17", "RBM22", "RBM25", "RBM28", "RBM3", "RBM39", "RBM4", "RBM45", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPJ", "RCC1", "RCC2", "RCL1", "RCOR1", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RIF1", "RIPK1", "RNASET2", "RNF14", "RNF2", "RNF20", "RNF219", "RNF40", "RNMT", "RNPS1", "ROCK1", "RPA1", "RPA2", "RPF1", "RPF2", "RPL10", "RPL13A", "RPP30", "RPRD1B", "RPS3", "RPS3A", "RPS6KA1", "RPS6KA3", "RPSA", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP1B", "RRP8", "RRP9", "RRS1", "RSF1", "RSL24D1", "RTCB", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SCAF1", "SCAF11", "SCAF4", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCD", "SCFD1", "SCML2", "SCP2", "SCRIB", "SCRN1", "SDAD1", "SDE2", "SDHA", "SDHB", "SEC13", "SEC14L2", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC24A", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SELENBP1", "SENP3", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERPINH1", "SET", "SETD2", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3GL1", "SH3GLB1", "SHMT2", "SIGMAR1", "SIL1", "SIN3A", "SIRT1", "SIRT2", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC2A1", "SLC30A7", "SLC35B2", "SLC35F2", "SLC38A1", "SLC3A2", "SLC7A1", "SLC7A5", "SLC9A3R1", "SLC9A6", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMARCA1", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMU1", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SON", "SORT1", "SPAG5", "SPC24", "SPC25", "SPECC1L", "SPEN", "SPTLC1", "SPTLC2", "SQSTM1", "SRCAP", "SREK1", "SRFBP1", "SRM", "SRPK1", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSBP1", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3", "STAT1", "STAT3", "STAU1", "STMN1", "STRAP", "STRBP", "STUB1", "STX12", "STX18", "STX4", "STX5", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUZ12", "SV2A", "SYAP1", "SYMPK", "SYNCRIP", "SYNGR2", "TACC3", "TAF2", "TAF5", "TAF6L", "TALDO1", "TAMM41", "TAOK1", "TARDBP", "TARS", "TARS2", "TBCB", "TBK1", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCF25", "TECR", "TERF2IP", "TFAM", "TFB1M", "TFG", "TFIP11", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THRAP3", "TIA1", "TIAL1", "TIGAR", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TK1", "TLN1", "TMCO1", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM115", "TMEM14C", "TMEM214", "TMX1", "TMX4", "TNPO1", "TNPO3", "TOMM20", "TOMM22", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOPBP1", "TP53", "TP53BP1", "TP53BP2", "TPI1", "TPR", "TPRKB", "TPX2", "TRA2A", "TRA2B", "TRAM1", "TRAPPC11", "TRAPPC4", "TRAPPC5", "TRAPPC8", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMT11", "TRMT112", "TRMT1L", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TSFM", "TSG101", "TSNAX", "TSR1", "TSR3", "TTC19", "TTC26", "TTC4", "TTLL12", "TTYH3", "TUBB2B", "TUFM", "TWNK", "TXLNA", "TXLNG", "TXNL1", "TXNL4A", "TXNRD1", "TYMS", "U2AF2", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBL5", "UBQLN4", "UBR1", "UBR4", "UBR5", "UBTF", "UBXN4", "UCHL5", "UFD1", "UFL1", "UFM1", "UGDH", "UHRF1", "UMPS", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP33", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP4", "UTP6", "VAMP7", "VAPA", "VAPB", "VARS1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VMP1", "VPS16", "VPS25", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4A", "VPS4B", "VPS50", "VRK1", "VTA1", "WAPL", "WARS", "WARS2", "WBP11", "WDR12", "WDR33", "WDR36", "WDR43", "WDR5", "WDR6", "WDR61", "WDR75", "WTAP", "XAB2", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YIF1A", "YIPF5", "YKT6", "YLPM1", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "ZBTB10", "ZC3H11A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCRB1", "ZMYND8", "ZNF207", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF638", "ZNF687", "ZPR1", "ZRANB2", "ZW10", "ZYX"], "leading_proteins": ["AAMP", "ABCB1", "ACAD11", "ACOX1", "ACOX3", "ACP6", "AGL", "AGPAT1", "AHCYL1", "AIFM1", "AKAP8", "AKAP8L", "AKT2", "ALDH3A2", "ANAPC2", "ANKRD17", "ANP32A", "ANXA1", "AP3M1", "AP3S1", "API5", "APOBEC3C", "APOL2", "ATP13A1", "ATP5L", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V1E1", "AUP1", "BABAM2", "BAG6", "BICD2", "CARM1", "CDK11B", "CERS2", "CHKA", "CNNM3", "CNNM4", "CPNE1", "CPT2", "CTNNBL1", "CTPS1", "CYB5B", "CYB5D2", "CYFIP1", "CYP51A1", "DDB1", "DDX5", "DHCR24", "DHFR", "DIABLO", "DNM1L", "ECI1", "EDF1", "ELOC", "ELP3", "ERAP1", "ERAP2", "ERC1", "ERG28", "ERGIC3", "EXO1", "EXOC5", "EXOC7", "F11R", "FAM162A", "FDFT1", "FERMT2", "FGFR1OP", "FMR1", "FOXRED1", "FXR1", "GADD45GIP1", "GBA", "GCLM", "GM2A", "GOLIM4", "GPAA1", "HADH", "HDAC2", "HEXIM1", "HGS", "HLA-A", "HLA-B", "HLA-C", "HMOX1", "HNRNPA2B1", "HNRNPD", "HNRNPK", "HNRNPU", "HTT", "IDH1", "IDH2", "IFT27", "IGF2R", "IWS1", "KDM5A", "KDSR", "KHDRBS3", "KHSRP", "KMT2A", "KPNA1", "KPNA3", "KPNA4", "KPNA6", "LARP7", "LASP1", "LBR", "LGALS3", "LPCAT1", "LSS", "LTA4H", "MAP2K4", "MAPK14", "MATR3", "MBOAT7", "MCL1", "MFSD14B", "MFSD3", "MFSD8", "MGEA5", "MIF", "MINDY3", "MRPL41", "MSMO1", "MTCH2", "MTMR6", "MTOR", "MTX1", "MYH10", "MYH9", "NAE1", "NAMPT", "NAP1L1", "NCSTN", "NDC1", "NDUFB3", "NDUFB9", "NDUFS2", "NPC1", "NPC2", "NSUN2", "NUP107", "NUP160", "NUP37", "NUP85", "NUP88", "OSBPL8", "OTUB1", "PAWR", "PDCD4", "PDCD5", "PDCL3", "PDE6D", "PECR", "PEX19", "PIBF1", "PIGS", "PLA2G15", "PLAA", "PLBD2", "PLD3", "PLD6", "PPP1CA", "PPP6C", "PPT1", "PRKAA1", "PRMT5", "PSAP", "PSMA3", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMD10", "PSME3", "PTGES2", "PTGR1", "PUF60", "PUM1", "QKI", "RAD21", "RAI14", "RALA", "RBM14", "RBM4", "RBM5", "RNASET2", "RTN3", "RTN4", "SCARB1", "SCARB2", "SDHB", "SEC13", "SEC23B", "SET", "SETD2", "SGPL1", "SGTA", "SHMT2", "SIN3A", "SIRT2", "SLC16A1", "SLC25A10", "SLC25A15", "SLC25A20", "SLC25A26", "SLC25A32", "SLC35F2", "SMARCE1", "SMN1*", "SMNDC1", "SNAP29", "SORT1", "SPTLC2", "SQSTM1", "STAM", "STX18", "SV2A", "SYNCRIP", "TAOK1", "TCAF1", "THOC1", "TIA1", "TIAL1", "TIMM17A", "TIMM17B", "TMX4", "TNPO1", "TOMM22", "TOMM5", "TRAM1", "TTC19", "TTYH3", "TUBB2B", "UBE3A", "UNC119B", "UQCRFS1", "USP24", "USP7", "VDAC1", "VDAC2", "XRN2", "ZCCHC3", "ZPR1"]} \ No newline at end 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https://git-lfs.github.com/spec/v1 +oid sha256:338c05cc3f513d13469450b08ec47a5e916fcd9258d9b3f48420429c5634509b +size 66251 diff --git a/protein_atlas_disease_involvement/df_merge.tsv b/protein_atlas_disease_involvement/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/protein_atlas_disease_involvement/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/protein_atlas_disease_involvement/metrics.json b/protein_atlas_disease_involvement/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..b2c97fc0961a9c55cc8cf4ceec37a322e1100d93 --- /dev/null +++ b/protein_atlas_disease_involvement/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2812, + "annotations_size": 112, + "title": "Average number of proteins per term", + "value": 19.982142857142858 +} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/paths.json b/protein_atlas_disease_involvement/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..80a25234ffbd5cc632d254f1005fa819bcf57309 --- /dev/null +++ b/protein_atlas_disease_involvement/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_disease_involvement/fragment/C428/C428_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_disease_involvement/result.tsv b/protein_atlas_disease_involvement/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..3cf6f20ce63f78f590ec03fa4d8313861a820338 --- /dev/null +++ b/protein_atlas_disease_involvement/result.tsv @@ -0,0 +1,36 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Neuronal ceroid lipofuscinosis 0.9654558404558378 1.907141660155263 0.0565022457404307 0.9985175586252522 0.4665258300732275 4 Q8NHS3,P50897,O75503 3 +Gangliosidosis 0.842076743779584 1.850499615619375 0.0642415733890955 0.9994106956761426 0.4665258300732275 5 P16278,P07602,P06865 3 +Proto-oncogene 0.4662196677992615 1.8146626326963171 0.0695757708753392 0.9996893486350048 0.4665258300732275 38 Q01105,Q92734,Q15022,Q01844,P31751,Q5M775,P35637,Q06136,O96028,Q96GG9,Q03164,Q92733,Q92804 13 +Gaucher disease 0.9644128113879002 1.8092892857137683 0.0704060726539417 0.9997189088743146 0.4665258300732275 2 P04062 1 +Spinocerebellar ataxia 0.6608417985223374 1.6739810429475697 0.0941343250815327 0.9999844709098382 0.5221351241366537 9 Q8IV08,Q9NXN4,O14773 3 +Mucopolysaccharidosis 0.7925540663309004 1.6504564167124116 0.0988496203710636 0.9999913444585704 0.5221351241366537 5 P54802,P08236 2 +Premature ovarian failure 0.8740213523131699 1.4383680929791156 0.1503296407933096 0.9999999880861415 0.6616776114473446 2 Q5JTZ9 1 +FDA approved drug targets 0.3523739090464959 1.4269173083125632 0.1536037312288478 0.9999999922685866 0.6616776114473446 109 P15260,O75874,Q16637,P68371,P21964,P04083,P49721,Q9NR33,P49356,P38435,Q16134,P10253,P62942,P48735,P21283,P31350,P36404,Q16850,P28074,P03886,P20618,Q16836,Q92769,Q02750,Q14534,P00374,P07437,P23786,P42345,Q7L0J3 30 +Cone-rod dystrophy 0.8612099644128106 1.3856516650771753 0.1658532940097399 0.9999999984893873 0.6634131760389597 2 Q6P4Q7 1 +Niemann-Pick disease 0.8523131672597979 1.3490673052875573 0.1773153486259893 0.9999999996792696 0.6848041050383035 2 O15118 1 +Neurodegeneration 0.3319278515715083 1.048182223328498 0.2945546591660519 1.0 0.7745964973837761 119 Q92734,Q8TB36,Q96B26,Q16637,Q9Y3I1,Q8TD16,Q10713,O75477,P35637,Q9NXN4,Q8NHS3,O75503,P06865,P43243,P07737,Q9Y287,Q96BR5,O95831,Q14671,P50897,Q8IV08,P50995,Q8N0X7,O15270,P03886,Q5JTZ9,P54802,Q14108,P04062,Q13501,O14773,P42858,P04792,Q96D71,Q8IXJ6 35 +Cushing syndrome 0.7379866740347006 1.0420473500900167 0.2973897266741283 1.0 0.7745964973837761 4 P40818 1 +Ichthyosis 0.5345176758876076 0.9725883419446724 0.3307579390499766 1.0 0.7881891313531358 8 P51648,O95721,P04062 3 +Primary mitochondrial disease 0.3208813813304708 0.789880112118513 0.4295977870718697 1.0 0.8748173118554438 77 Q96CU9,O43676,Q70HW3,Q5JTZ9,O75306,P47985,Q6DKK2,Q9UBX3,Q9Y2R0 9 +Cancer-related genes 0.2999331631212993 0.7729859710101383 0.4395306832959631 1.0 0.8790613665919262 341 Q92734,P07099,Q99595,O00743,P10644,Q03164,P62993,Q14258,P07858,Q6UN15,Q16539,Q15022,P46977,P27635,P18074,Q14247,Q12888,P43490,Q16204,Q96DH6,P48735,P80303,Q92804,P09601,Q06124,Q06136,O75874,P35637,O96028,P08236,Q9BQE5,O95684,P04439,P01889,P21266,P21912,Q969G3,Q5JTZ9,P08183,Q86X55,Q99543,Q92733,P67809,P98175,Q07820,P31751,Q08380,P00374,Q01105,P14174,P29375,P38159,P04083,P22626,P09960,Q16543,Q8IUD2,P45985,P11717,P50995,Q14847,Q9BYW2,Q01844,Q02750,Q9H7B4,O60216,P11940,Q96PU8,Q8IWS0,Q12955,Q96ST3,Q8WYA6,P17931,Q92769,P40818,P30153,P04792,Q8IXJ6,P42345 79 +Ectodermal dysplasia 0.5660149936697961 0.721255812656152 0.4707521381991819 1.0 0.9110837547900048 5 Q9H1A4,Q02750 2 +Deafness 0.337539370009744 0.7195351867055619 0.4718112301591097 1.0 0.9110837547900048 47 O76024,Q9Y287,P68371,Q9NR28,P18074,O95831,Q15067,Q969T9,O60443,Q16740,Q06124 11 +Non-syndromic deafness 0.4019151625691307 0.6960988427277697 0.4863669312307483 1.0 0.9232728186075224 17 O76024,O60443,Q969T9,Q9NR28 4 +Osteogenesis imperfecta 0.4835852196443501 0.6784511342335534 0.4974856969905286 1.0 0.9286399677156534 7 Q32P28,O75718 2 +Hereditary nonpolyposis colorectal cancer 0.6501779359430602 0.5611302099253878 0.5747087751001785 1.0 0.9674355017924842 2 P52701 1 +Primary microcephaly 0.4378766816413461 0.5168598179779704 0.6052540192378126 1.0 0.9674355017924842 8 Q86XL3 1 +Cockayne syndrome 0.6548738964534491 0.4627518870303882 0.6435422215931623 1.0 0.9674355017924842 3 P18074 1 +Xeroderma pigmentosum 0.6548738964534491 0.4627518870303882 0.6435422215931623 1.0 0.9674355017924842 3 P18074 1 +Progressive external ophthalmoplegia 0.6539693841224764 0.4600887620664495 0.6454525101137314 1.0 0.9674355017924842 3 Q9BQP7,Q96RR1 2 +Tumor suppressor 0.314844450117636 0.3857751843102223 0.699663175403493 1.0 0.9674355017924842 24 O60443,Q9BYW2,P38159,Q9NZB2 4 +Joubert syndrome 0.5388680703535254 0.3496653071412302 0.7265898928854748 1.0 0.9748686561413192 4 O43924 1 +Palmoplantar keratoderma 0.4058643003269628 0.3486856274410881 0.7273253355189859 1.0 0.9748686561413192 7 Q06136 1 +Craniosynostosis 0.4814425762892534 0.2011912839002562 0.8405490065922381 1.0 1.0 4 P16435,P07237 2 +Amyotrophic lateral sclerosis 0.291781110802329 0.100120561746795 0.9202486114381104 1.0 1.0 15 P50995,P35637,P07737,P43243,Q13501 5 +Epilepsy 0.2580044728329746 0.0659404230962965 0.9474252576213892 1.0 1.0 54 Q14108,O75503 2 +Li-Fraumeni syndrome 0.3829181494661949 0.0380928155131878 0.9696136795443352 1.0 1.0 2 O96017 1 +Primary ciliary dyskinesia 0.3380782918149543 0.0249068052811345 0.9801292990899028 1.0 1.0 2 P49454 1 +Aicardi-Goutieres syndrome 0.3497150997151016 0.0102284639871658 0.9918390088066504 1.0 1.0 4 P55265,Q5TBB1,O75792 3 +Congenital myasthenic syndrome 0.3670345318618749 0.0092866671912938 0.9925904181299968 1.0 1.0 3 Q4J6C6,P53007 2 +Neuropathy 0.2558569835449583 0.0017970805281461 0.9985661379638486 1.0 1.0 44 Q92734,Q8TB36,Q96BR5,Q15067,O15270,P04792,P54802,O95721 8 diff --git a/protein_atlas_disease_involvement/selections.json b/protein_atlas_disease_involvement/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..684ebd2995227edd06e2e382ea419c3c3df1b5ac --- /dev/null +++ b/protein_atlas_disease_involvement/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Aicardi-Goutieres syndrome", "Albinism", "Allergen", "Alport syndrome", "Alzheimer disease", "Amelogenesis imperfecta", "Amyloidosis", "Amyotrophic lateral sclerosis", "Atrial fibrillation", "Autism", "Autism spectrum disorder", "Bardet-Biedl syndrome", "Bartter syndrome", "Brugada syndrome", "Cancer-related genes", "Cardiomyopathy", "Cataract", "Charcot-Marie-Tooth disease", "Ciliopathy", "Cockayne syndrome", "Cone-rod dystrophy", "Congenital adrenal hyperplasia", "Congenital disorder of glycosylation", "Congenital dyserythropoietic anemia", "Congenital hypothyroidism", "Congenital muscular dystrophy", "Congenital myasthenic syndrome", "Craniosynostosis", "Cushing syndrome", "Deafness", "Diabetes insipidus", "Diabetes mellitus", "Diamond-Blackfan anemia", "Disease variant", "Dwarfism", "Dyskeratosis congenita", "Dystonia", "Dystroglycanopathy", "Ectodermal dysplasia", "Ehlers-Danlos syndrome", "Elliptocytosis", "Emery-Dreifuss muscular dystrophy", "Epidermolysis bullosa", "Epilepsy", "FDA approved drug targets", "Fanconi anemia", "Gangliosidosis", "Gaucher disease", "Glaucoma", "Glutaricaciduria", "Glycogen storage disease", "Gout", "Hereditary hemolytic anemia", "Hereditary nonpolyposis colorectal cancer", "Hereditary spastic paraplegia", "Hermansky-Pudlak syndrome", "Hirschsprung disease", "Holoprosencephaly", "Hypogonadotropic hypogonadism", "Hypotrichosis", "Ichthyosis", "Intrahepatic cholestasis", "Joubert syndrome", "Kallmann syndrome", "Kartagener syndrome", "Leber congenital amaurosis", "Leber hereditary optic neuropathy", "Leigh syndrome", "Leukodystrophy", "Li-Fraumeni syndrome", "Limb-girdle muscular dystrophy", "Lissencephaly", "MELAS syndrome", "Maple syrup urine disease", "Meckel syndrome", "Mental retardation", "Metachromatic leukodystrophy", "Microphthalmia", "Mucopolysaccharidosis", "Myofibrillar myopathy", "Nemaline myopathy", "Nephronophthisis", "Neurodegeneration", "Neuronal ceroid lipofuscinosis", "Neuropathy", "Niemann-Pick disease", "Non-syndromic deafness", "Obesity", "Oncogene", "Osteogenesis imperfecta", "Palmoplantar keratoderma", "Parkinson disease", "Parkinsonism", "Peroxisome biogenesis disorder", "Premature ovarian failure", "Primary ciliary dyskinesia", "Primary hypomagnesemia", "Primary microcephaly", "Primary mitochondrial disease", "Progressive external ophthalmoplegia", "Proto-oncogene", "Pyropoikilocytosis", "Retinitis pigmentosa", "Rhizomelic chondrodysplasia punctata", "SCID", "Schizophrenia", "Spinocerebellar ataxia", "Systemic lupus erythematosus", "Tumor suppressor", "Williams-Beuren syndrome", "Xeroderma pigmentosum", "Zellweger syndrome"], "available_proteins": ["AAAS", "AARS", "AARS2", "ABCB1", "ABCB7", "ABCC1", "ABHD12", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACBD5", "ACLY", "ACO1", "ACO2", "ACOX1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ADAR", "ADD3", "ADK", "ADNP", "ADSL", "AFDN", "AFG3L2", "AGK", "AGL", "AGPS", "AHCY", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AKAP12", "AKR1B1", "AKT2", "ALDH18A1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDOA", "ALDOC", "ALG1", "AMPD2", "ANAPC1", "ANK3", "ANKLE2", "ANLN", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA7", "AP1B1", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "APEX1", "APOL2", "APPL1", "APRT", "ARCN1", "ARG2", "ARHGDIA", "ARHGEF2", "ARID1A", "ARID3B", "ARIH1", "ARL2", "ARL3", "ARL6", "ARL6IP1", "ASAH1", "ASCC1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD3A", "ATIC", "ATP11C", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5A1", "ATP6AP1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1E1", "ATXN10", "B3GALT6", "B4GAT1", "BANF1", "BAZ1B", "BCAP31", "BCLAF1", "BCOR", "BCS1L", "BICD2", "BIRC6", "BLMH", "BLVRB", "BMS1", "BPTF", "BRI3BP", "BUB1B", "C19orf70", "C1QBP", "CACNA2D1", "CAD", "CALR", "CAMK2G", "CANX", "CAPN1", "CARM1", "CARS", "CASK", "CAST", "CBFB", "CCAR1", "CCAR2", "CCDC22", "CCDC47", "CCDC6", "CCDC8", "CCNB1", "CCNB2", "CCT5", "CDC16", "CDC27", "CDC37", "CDC42", "CDC73", "CDH2", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDKAL1", "CENPF", "CEP55", "CFL2", "CHAMP1", "CHD1", "CHD4", "CHD7", "CHEK2", "CHMP2B", "CHMP4B", "CISD2", "CKAP2L", "CKB", "CKMT1A*", "CLIC1", "CLN5", "CLPB", "CLPP", "CLPX", "CLTC", "CNNM4", "CNOT1", "COA3", "COA7", "COG2", "COG7", "COLGALT1", "COMT", "COPA", "COPB2", "COX15", "COX2", "COX4I1", "COX5A", "CPOX", "CPSF1", "CPT2", "CRTAP", "CSDE1", "CSE1L", "CSNK2A2", "CSNK2B", "CSTB", "CTBP1", "CTCF", "CTNNB1", "CTNNBL1", "CTNND1", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CWF19L1", "CYB5R3", "CYC1", "CYP51A1", "DAD1", "DARS", "DARS2", "DBN1", "DBT", "DCPS", "DCTN1", "DCUN1D1", "DDOST", "DDRGK1", "DDX10", "DDX3X", "DDX41", "DDX5", "DDX6", "DEK", "DHCR24", "DHCR7", "DHFR", "DHX16", "DHX30", "DHX37", "DHX38", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DIS3", "DKC1", "DLD", "DLST", "DNAAF5", "DNAJB1", "DNAJB11", "DNAJC13", "DNAJC2", "DNAJC3", "DNM1L", "DNM2", "DNMT1", "DOCK7", "DPM1", "DSG2", "DSP", "DYNC1H1", "DYNLL1", "EARS2", "ECE1", "ECHS1", "EEF1A2", "EEF2", "EFL1", "EFTUD2", "EHMT1", "EI24", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S2", "EIF3E", "EIF3F", "EIF3H", "EIF4A2", "EIF4A3", "EIF4G1", "EIF4H", "EIF5A", "ELAC2", "ELP1", "ELP2", "ELP3", "EMC1", "EMD", "EMG1", "EML4", "ENO1", "ENO2", "EPB41", "EPB41L3", "EPHX1", "EPPK1", "EPRS", "EPS15", "ERAL1", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERGIC1", "ERLIN1", "ERLIN2", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXOSC2", "EXOSC3", "EXOSC8", "EXOSC9", "EZR", "FAF1", "FAH", "FAM120A", "FANCD2", "FANCI", "FAR1", "FARSB", "FASN", "FBXO7", "FDPS", "FDXR", "FECH", "FEN1", "FGFR1OP", "FH", "FIP1L1", "FKBP10", "FKBP1A", "FKBP5", "FKBP8", "FLAD1", "FLNA", "FLNB", "FLNC", "FMR1", "FNTA", "FNTB", "FOXRED1", "FSCN1", "FTO", "FUBP1", "FUCA1", "FUS", "G6PD", "GAA", "GALK1", "GALM", "GALNT2", "GAMT", "GANAB", "GAPDH", "GARS", "GART", "GATAD2B", "GATB", "GBA", "GCDH", "GCLM", "GDAP1", "GDAP2", "GDI1", "GEMIN4", "GFM1", "GFPT1", "GGCX", "GIGYF2", "GLA", "GLB1", "GLDC", "GLMN", "GLO1", "GLRX5", "GLS", "GLUD1", "GM2A", "GMPPA", "GMPS", "GNA13", "GNAI3", "GNPAT", "GNS", "GOT1", "GOT2", "GPAA1", "GPD1L", "GPHN", "GPI", "GRB2", "GSDME", "GSR", "GSS", "GSTM3", "GTF2I", "GTPBP3", "GUSB", "GYG1", "GYS1", "H4C1*", "HADH", "HADHA", "HADHB", "HCFC1", "HDAC1", "HDAC2", "HELLS", "HEXA", "HEXB", "HIBCH", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLCS", "HMBS", "HMGA1", "HMGA2", "HMGB3", "HMGCR", "HMOX1", "HNRNPA1", "HNRNPA2B1", "HNRNPDL", "HNRNPH2", "HNRNPK", "HNRNPU", "HPRT1", "HSD17B10", "HSD17B4", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA2", "HSPA4", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HSPH1", "HTT", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFNGR1", "IFT27", "IGBP1", "IGF1R", "IGF2R", "ILF3", "IMPAD1", "IMPDH2", "INTS1", "IPO7", "IQSEC1", "IRF2BPL", "IRS4", "ITGB1", "ITM2B", "ITPA", "IVD", "JAGN1", "JUP", "KARS", "KDM1A", "KDM3B", "KDM5A", "KDSR", "KIF11", "KIF14", "KIF1A", "KIF1B", "KIF22", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KMT2A", "KTN1", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LDHA", "LDHB", "LEMD2", "LEMD3", "LGALS3", "LGALS3BP", "LMNA", "LMNB1", "LMNB2", "LONP1", "LRBA", "LRP1", "LRPPRC", "LRSAM1", "LSS", "LTA4H", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAP1B", "MAP2K1", "MAP2K4", "MAP4", "MAPK1", "MAPK14", "MARS", "MATR3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM5", "MCM7", "MDC1", "MDH1", "MDH2", "MECP2", "MFN2", "MFSD8", "MGME1", "MICU1", "MID1", "MIF", "MIPEP", "MKI67", "MMADHC", "MOGS", "MORC2", "MPDU1", "MPI", "MRE11", "MRPL12", "MRPL3", "MRPL44", "MRPS2", "MRPS22", "MRPS23", "MRPS28", "MRPS34", "MRPS7", "MSH2", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTHFS", "MTOR", "MTPAP", "MTR", "MUT", "MYH10", "MYH9", "MYO6", "NAA15", "NAGLU", "NAMPT", "NANS", "NAXE", "NBAS", "NCAPD2", "NCAPD3", "NCAPH", "NCSTN", "ND1", "NDUFA10", "NDUFA13", "NDUFA4", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFB3", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV2", "NEDD4L", "NEK9", "NF1", "NHLRC2", "NHP2", "NIPBL", "NME1", "NNT", "NONO", "NOP56", "NPC1", "NPC2", "NPM1", "NSD2", "NSDHL", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NUCB2", "NUDT1", "NUMA1", "NUP107", "NUP133", "NUP155", "NUP160", "NUP188", "NUP205", "NUP214", "NUP37", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NXN", "OAT", "OCRL", "OGDH", "OGT", "OPA1", "OSGEP", "OXCT1", "P3H1", "P4HB", "PABPC1", "PABPN1", "PAF1", "PAFAH1B1", "PAPSS2", "PARK7", "PARN", "PARP1", "PBRM1", "PC", "PCBD1", "PCBP1", "PCCA", "PCCB", "PCM1", "PCNA", "PDAP1", "PDCD4", "PDE6D", "PDHA1", "PDHB", "PDK3", "PEPD", "PEX14", "PEX19", "PFKM", "PFN1", "PGK1", "PGM1", "PGM3", "PHB", "PHF6", "PHGDH", "PHIP", "PI4KA", "PIBF1", "PICALM", "PIGK", "PIGS", "PIGT", "PIK3C2A", "PKM", "PLAA", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNN", "PNP", "PNPT1", "POGZ", "POLA1", "POLD1", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR3A", "POLR3B", "POP1", "POR", "PPA2", "PPIB", "PPIF", "PPOX", "PPP1CB", "PPP1R12A", "PPP2R1A", "PPP2R5D", "PPP3CA", "PPP5C", "PPP6C", "PPT1", "PRC1", "PRCC", "PRDX2", "PRDX4", "PRDX5", "PREPL", "PRKAA1", "PRKACA", "PRKAG1", "PRKAR1A", "PRKCB", "PRKCSH", "PRKDC", "PRPF3", "PRPF31", "PRPF4", "PRPF6", "PRPF8", "PSAP", "PSAT1", "PSIP1", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMD12", "PTPN11", "PTRH2", "PUF60", "PUM1", "PURA", "PUS7", "PYCR1", "PYCR2", "PYGL", "QARS", "QKI", "QPRT", "RAB10", "RAB18", "RAB23", "RAB3GAP2", "RAB7A", "RAB8A", "RAC1", "RAD21", "RAD23B", "RANBP2", "RANBP3", "RAP1GDS1", "RAPGEF2", "RARS", "RBM10", "RBM12", "RBM15", "RBM28", "RBMX", "RBPJ", "RDH11", "RDX", "REPS1", "RFC1", "RFC2", "RIPK1", "RNASEH2A", "RNASEH2B", "RNASET2", "ROCK1", "RPA2", "RPL10", "RPL11", "RPL13", "RPL15", "RPL18", "RPL21", "RPL22", "RPL26", "RPL27", "RPL3", "RPL35", "RPL35A", "RPL5", "RPN1", "RPS10", "RPS15", "RPS15A", "RPS17", "RPS19", "RPS2", "RPS23", "RPS24", "RPS26", "RPS28", "RPS3", "RPS6KA1", "RPS6KA3", "RPS7", "RPSA", "RRM1", "RRM2", "RTN4IP1", "SAMHD1", "SARS", "SART1", "SBDS", "SCARB2", "SCO1", "SCO2", "SCRIB", "SCYL2", "SDHA", "SDHB", "SEC23A", "SEC23B", "SEC31A", "SEC61A1", "SEC63", "SELENBP1", "SEPT2", "SEPT9", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETDB1", "SF3B1", "SFPQ", "SFXN4", "SGPL1", "SH3GL1", "SIGMAR1", "SIL1", "SIN3A", "SIRT2", "SKIV2L", "SKP2", "SLC12A2", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC2A1", "SLC38A1", "SLC3A2", "SLC9A3R1", "SLC9A6", "SMARCA4", "SMARCAD1", "SMARCB1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC3", "SMCHD1", "SMN1*", "SMPD4", "SMYD3", "SNAP29", "SND1", "SNRNP200", "SNRPE", "SNX3", "SOD2", "SON", "SORD", "SPART", "SPECC1", "SPECC1L", "SPEN", "SPR", "SPTAN1", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRP54", "SRP72", "SRSF3", "SSB", "STAG1", "STAG2", "STARD3", "STAT1", "STAT3", "STMN1", "STRAP", "STT3A", "STT3B", "STUB1", "STX5", "SUCLA2", "SUCLG1", "SUZ12", "SV2A", "SYNE2", "TAF15", "TAF2", "TALDO1", "TARDBP", "TARS", "TARS2", "TBC1D4", "TBC1D8B", "TBCD", "TBCE", "TBK1", "TBL2", "TCEA1", "TCF20", "TCOF1", "TECR", "TELO2", "TFAM", "TFG", "TFRC", "THOC2", "THOC6", "TIA1", "TIMM17A", "TIMM50", "TK1", "TKT", "TMCO1", "TMEM199", "TMEM230", "TMEM43", "TMTC3", "TMX2", "TNPO3", "TOP1", "TOP2A", "TOP2B", "TOR1AIP1", "TP53", "TP53BP1", "TP53BP2", "TPD52", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPR", "TPRKB", "TPX2", "TRAPPC11", "TRIM24", "TRIM25", "TRIM33", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMU", "TRRAP", "TSFM", "TSG101", "TTC19", "TTC21B", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "TWF1", "TWNK", "TXLNA", "TXNL4A", "TXNRD1", "TXNRD2", "TYMS", "UBA1", "UBE3A", "UBQLN4", "UBR1", "UBR5", "UBTF", "UFM1", "UGDH", "UGP2", "UMPS", "UNC119", "UNG", "UPF3B", "UQCRB", "UQCRC2", "UQCRFS1", "UQCRQ", "USMG5", "USP8", "USP9X", "UTP4", "VAPB", "VARS1", "VCL", "VCP", "VIM", "VPS16", "VPS33A", "VPS33B", "VPS35", "VPS4A", "VRK1", "WARS", "WARS2", "WBP2", "WDR1", "WDR11", "WDR36", "WDR5", "WFS1", "WNK1", "XPNPEP3", "XPO1", "XRCC1", "XRCC5", "XRCC6", "XRN1", "YARS", "YARS2", "YBX1", "YEATS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAZ", "ZC3H14", "ZMPSTE24"], "leading_proteins": ["AARS2", "ABCB1", "ACOX1", "ADAR", "AIFM1", "AKT2", "ALDH3A2", "ANAPC1", "ANK3", "ANKLE2", "ANXA1", "ANXA11", "APOL2", "ARL2", "ATP6V1C1", "BICD2", "CARM1", "CCDC6", "CDC37", "CENPF", "CHEK2", "CLN5", "CLPP", "CNNM4", "COA3", "COA7", "COMT", "CPT2", "CRTAP", "CTNNBL1", "CTSB", "CTTN", "CYP51A1", "DCUN1D1", "DHFR", "DIABLO", "DNAJC2", "EPHX1", "ERC1", "ERCC2", "ERLIN1", "ETFDH", "EWSR1", "EXOSC8", "FAM120A", "FBXO7", "FGFR1OP", "FIP1L1", "FKBP1A", "FNTB", "FOXRED1", "FUS", "GAA", "GBA", "GDAP1", "GDAP2", "GGCX", "GLB1", "GRB2", "GSDME", "GSTM3", "GUSB", "HADH", "HDAC2", "HEXA", "HLA-A", "HLA-B", "HMOX1", "HNRNPA2B1", "HSPB1", "HTT", "IDH1", "IDH2", "IFNGR1", "IGF2R", "ITM2B", "KDM5A", "KDSR", "KMT2A", "LASP1", "LGALS3", "LGALS3BP", "LTA4H", "MAP2K1", "MAP2K4", "MAPK14", "MATR3", "MCL1", "MFSD8", 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sha256:50ac54aaa6a44753169e386d464cacab85a705b3b92269c16149d43707d4f0ed +size 73124 diff --git a/protein_atlas_molecular_function/df_merge.tsv b/protein_atlas_molecular_function/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..bfb2d32b6da1baa0eeacc47d091f5e429eea4ec3 --- /dev/null +++ b/protein_atlas_molecular_function/df_merge.tsv @@ -0,0 +1,8 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Protease 24 75 3.160062477875621 0.0015773531074787 20.788834951456312 82.44417475728156 1.1215350835872162 0.3507517256058336 6.07090559629836 8.079357013764625 1.4678877461728397 0.3691345771929886 0.0001680082398725 0.0051877599769984 0.0003561819473979 0.0001399666010501 6.339045959783907e-06 +Receptor 12 34 3.148733760006324 0.0016397951587274 13.475728155339803 38.71116504854369 1.6655960679271569 0.1791616261110447 5.431559450288914 6.105192092581698 1.9169648296245776 0.2753083483896962 0.2458623134343485 0.3479185756413622 0.0927526620327515 0.257017205453369 0.2339314813187557 +Glycosidase 11 17 3.059478486771084 0.0022172271137881 7.798543689320389 18.135922330097088 0.5112745472223946 0.1951515073440806 2.9064203812520417 1.9684331341643595 1.9501681029822375 0.2619382904734375 0.2568414051025549 0.1908924307699622 0.0007430351028178 6.595475320695919e-07 5.800761964405292e-07 +Metalloprotease 12 26 2.4316157515160097 0.0150316444721176 8.160194174757281 26.429611650485437 1.390302281711237 0.2661274848815638 3.192614043118206 1.543038499308978 1.1108461579919544 0.309446154241223 0.0600470967338244 0.2486824788491954 0.0181443698350236 0.0509365284789281 0.0004229506315236 +Host cell receptor for virus entry 3 13 2.2916438671536943 0.0219262019684329 4.509708737864078 15.157766990291265 0.7214109752050332 0.2527966464979699 2.499010078306418 1.9009100692398744 1.5211756979359785 0.2791170769282048 0.2516826286650005 0.1868885334554594 0.0075361578498098 0.0801176308941427 0.051296284939533 +Carboxypeptidase 3 6 2.224228693933655 0.0261330614295522 3.1359223300970873 6.150485436893204 0.9957728306848488 0.1212034427500092 1.2071674596015187 0.4479454254223922 1.8250051834990677 0.2074401112551974 0.0001329187100722 0.0023758658868836 0.0003602808960722 0.0050923434600555 0.0048822579474643 +Protease inhibitor 1 6 2.111795008314421 0.0347040356378014 2.679611650485437 6.827669902912621 -0.1389909380340853 0.4401686430319619 1.73744367643855 1.203518872907143 1.1014803254493444 0.2988298098237953 0.158384106221839 0.1157751708195439 0.2147385524083838 0.1211421538065826 0.3442759855295882 diff --git a/protein_atlas_molecular_function/metrics.json b/protein_atlas_molecular_function/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..50034156602cfa21005b36fefc0d94a14797f5fa --- /dev/null +++ b/protein_atlas_molecular_function/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2812, + "annotations_size": 97, + "title": "Average number of proteins per term", + "value": 34.670103092783506 +} \ No newline at end of file diff --git a/protein_atlas_molecular_function/paths.json b/protein_atlas_molecular_function/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..89e9a66e781c540cbee37df44379406ca91df487 --- /dev/null +++ b/protein_atlas_molecular_function/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_molecular_function/fragment/C428/C428_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_molecular_function/result.tsv b/protein_atlas_molecular_function/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..2082d7315bf335e518fa0b32b2e4b0393e92ba4c --- /dev/null +++ b/protein_atlas_molecular_function/result.tsv @@ -0,0 +1,38 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Protease 0.5206514138783936 3.160062477875621 0.0015773531074787 0.1419767213303987 0.0397650325991413 75 Q96FW1,P42785,O75976,Q6P179,Q9UIQ6,Q9UPU5,Q5JRX3,P09960,P07858,Q8TEY7,Q9HB40,Q96FZ2,P28072,O75844,Q8TCT9,P10619,P28074,Q99436,P42892,Q96K76,Q16740,O14773,Q9BYT8,Q96RU2 24 +Receptor 0.6392291731081823 3.148733760006324 0.0016397951587274 0.1471662801198744 0.0397650325991413 34 P55899,Q14739,Q8WTV0,Q9NS69,P15260,P11717,Q99523,O15118,O15173,Q14108,Q9Y624,O00264 12 +Glycosidase 0.7892940401350291 3.059478486771084 0.0022172271137881 0.1937083987234553 0.0414529135735774 17 P16278,P35573,P06280,Q9BTY2,P10253,P54802,P08236,P06865,P04062,O60502,Q8IW92 11 +Metalloprotease 0.5702144195543685 2.4316157515160097 0.0150316444721176 0.7698765040608315 0.0911293446122135 26 Q9BYT8,P52888,P55786,Q9NZ08,O75976,P42892,Q6P179,Q9NQH7,Q9UIQ6,O75844,Q5JRX3,P09960 12 +Host cell receptor for virus entry 0.701122037237621 2.2916438671536943 0.0219262019684329 0.883574641090178 0.1251083288787058 13 O15118,Q14108,Q8WTV0 3 +Carboxypeptidase 0.863385208920018 2.224228693933655 0.0261330614295522 0.9233586101573644 0.1408281643703651 6 P10619,Q9HB40,P42785 3 +Protease inhibitor 0.8362324475289484 2.111795008314421 0.0347040356378014 0.9674862111375812 0.168314572843337 6 P30086 1 +Acyltransferase 0.4875576918174256 1.8242805766183752 0.0681096653173465 0.9989324546948328 0.2541014436839466 28 Q86UY6,P30419,Q8NF37,O15270,Q8NCC3,Q9BWD1,Q99943,P23786 8 +Porin 0.9293773072791828 1.7720992315477286 0.0763780864960761 0.9995502821325696 0.2743953477821994 4 P21796 1 +Hydrolase 0.3395864475159287 1.7401419224402868 0.0818341005692604 0.999746864863746 0.2834967055435094 345 Q9BYT8,P07099,Q96FW1,Q9NTK5,Q9NRW3,P62136,P55786,Q9BTY2,P42785,O75976,P08236,P06865,P36543,Q6P179,Q9UIQ6,Q9UPU5,Q5JRX3,O60502,P09960,P07858,Q9NVE7,P16278,Q8N2A8,Q9HB40,O00584,Q969T7,Q8TEY7,Q96FZ2,P28072,P06280,Q9NPH0,Q9BQP7,P10253,Q6ZT21,O75844,Q9UMR5,Q8NHP8,Q8TCT9,P10619,P50897,Q12972,P28074,Q99436,Q8IV08,Q9H773,Q92820,P54802,P11117,Q8NCC3,P42892,P04062,Q96K76,Q9NUJ1,Q8IW92,Q06124,Q16740,O14773,Q9Y217,Q15165,Q9H993,Q8N3C0,Q5TFE4,Q8IX18,P35573,Q9UQ84,Q96C86,P17900,Q96RU2 68 +Thiol protease 0.4608758224309155 1.5844234593079995 0.1130973868930373 0.9999912104701782 0.3656815509541542 25 Q96FW1,Q8TEY7,Q96RU2,Q9H8M7,Q96K76,Q9UPU5,P07858 7 +Monooxygenase 0.8943060498220718 1.5218525412630115 0.1280460329686712 0.9999983100451024 0.3874616539758853 2 Q16850 1 +Methyltransferase 0.4333169842896945 1.506975835056605 0.1318168513526207 0.999998890055813 0.3874616539758853 37 Q8N6R0,Q9BYW2,Q9H993,O60725,P21964,O96028,Q08J23,Q86X55,Q03164,Q9BV86 10 +Threonine protease 0.9298682805268826 1.41694785721155 0.1564981730127224 0.999999932338024 0.4461087004561019 3 P28072,P28074 2 +Serine protease inhibitor 0.9217417184381468 1.3871245708747202 0.1654037808249961 0.9999999758335943 0.4461087004561019 3 P30086 1 +Glycosyltransferase 0.4246717881286591 1.3207599335977436 0.1865814230912537 0.9999999980025938 0.4506071664843533 29 Q13126,P43490,O43505 3 +Aminopeptidase 0.5690916796470461 1.3092111895553018 0.1904628229469946 0.9999999987440584 0.4506071664843533 10 Q9UIQ6,P55786,Q9NZ08,Q6P179 4 +Dioxygenase 0.5202921247129654 1.2738673582475124 0.2027104283669212 0.9999999997137404 0.4681645607521751 13 Q32P28,O00625,P29375,P13674 4 +Translocase 0.4576845497249551 1.1925842366920452 0.2330322423849731 0.9999999999933414 0.523590488628972 20 O75306,Q9HD20,P08183 3 +Prenyltransferase 0.8573083721001415 1.151175680292612 0.249659968160522 0.9999999999992056 0.5264568893819704 3 P49356 1 +Tyrosine-protein kinase 0.6023963565950239 1.0939472818946 0.2739781000696364 0.9999999999999676 0.5654441639735049 6 P45985 1 +Cytokine 0.734761767379174 1.0297964878078931 0.3031055498147696 0.9999999999999992 0.6125257985840137 4 P43490 1 +Endonuclease 0.4234224846029374 0.8321409230685191 0.4053294051350486 1.0 0.7280917092240689 17 Q8N2A8,O00584,Q9UQ84 3 +Oxidoreductase 0.3245607396775938 0.7332531844317841 0.4634040227692151 1.0 0.7750032794588597 152 Q96CU9,O75874,Q15392,Q14914,P29375,O15254,Q15800,Q9BY49,Q8N4Q0,P30519,P13674,Q9BU89,Q9UHG3,P48735,O95881,P21912,Q16850,P78417,P09601,P23378,Q5VT66,Q32P28,Q14739,Q16836,Q8NB78,Q06136,O75306,P00374,Q8NBX0 29 +Guanine-nucleotide releasing factor 0.3975688686705955 0.6472898060577336 0.5174443978195629 1.0 0.8228214194835672 16 P80303 1 +Muscle protein 0.486446987820753 0.5897951238551522 0.5553280121838167 1.0 0.839396561907644 6 P60660,P14649 2 +Nuclease 0.333917272952518 0.5791584968510569 0.5624822322061531 1.0 0.839396561907644 32 Q8N2A8,O00584,Q8IV08,Q9BQP7,Q9UQ84 5 +Chromatin regulator 0.2937863706010165 0.4296623746045496 0.667441256911244 1.0 0.8991916933387593 74 Q8NB78,Q969G3,P46379,Q9NXR7,O96028,Q9UFC0,Q86X55,Q03164,Q99543 9 +Cyclin 0.498932384341627 0.156761866877834 0.8754325270320047 1.0 1.0 2 P14635 1 +Peroxidase 0.3578047042052709 0.1390024946331273 0.8894481777550296 1.0 1.0 6 P32119,P30041,Q13162,Q8TED1,P30048 5 +Exonuclease 0.2947381665880266 0.1246035842792707 0.9008373906711168 1.0 1.0 19 Q8IV08,Q9UQ84 2 +tRNA-binding 0.2896440369273219 0.0918925659758515 0.9267833979634552 1.0 1.0 17 O75648,Q9HAV4,Q5JTZ9,Q08J23,Q9H9T3 5 +Calcium channel 0.4526690391459071 0.0906588556147536 0.9277636644092844 1.0 1.0 2 Q9UM00 1 +Repressor 0.2541113639477049 0.0624382246496633 0.9502138554599178 1.0 1.0 106 Q99829,P16989,Q9UK61,Q13363,O14979,P38159,O60216,P39687,Q13242,Q9UHX1,Q9NX63,Q12972,P61978,Q8IXH7,Q9HCD5,Q96ST3,Q14011,P67809,Q01844,Q06787,Q92769,Q8NB78,O94992,P62995,Q9BQ70,Q96PK6 26 +Serine/threonine-protein kinase 0.261737499202313 0.0393753867639545 0.9685911032043352 1.0 1.0 43 P78527,Q16539,Q7L7X3,O60566,P11802,P45985,P31751,O14976,Q02750,P21127,Q13131,Q9NYV4,Q96KB5,O14936,P42345,P48729 16 +Myosin 0.2918463170428866 0.013864949432597 0.988937725341976 1.0 1.0 8 P60660 1 +Thiol protease inhibitor 0.3246707013171966 0.0009224808613713 0.999263966867466 1.0 1.0 3 P04080,Q9NR09 2 diff --git a/protein_atlas_molecular_function/selections.json b/protein_atlas_molecular_function/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..ff7bc2e23c7886ffc35d23e3537dd3c377505847 --- /dev/null +++ b/protein_atlas_molecular_function/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin capping", "Actin-binding", "Activator", "Acyltransferase", "Allosteric enzyme", "Aminoacyl-tRNA synthetase", "Aminopeptidase", "Aminotransferase", "Antibiotic", "Antimicrobial", "Antioxidant", "Aspartyl protease", "Blood group antigen", "Calcium channel", "Calmodulin-binding", "Carboxypeptidase", "Chaperone", "Chloride channel", "Chromatin regulator", "Cyclin", "Cytokine", "DNA-binding", "DNA-directed DNA polymerase", "Decarboxylase", "Developmental protein", "Dioxygenase", "Dipeptidase", "Elongation factor", "Endonuclease", "Excision nuclease", "Exonuclease", "Fungicide", "GTPase activation", "Glycosidase", "Glycosyltransferase", "Growth factor", "Guanine-nucleotide releasing factor", "Helicase", "Heparin-binding", "Hormone", "Host cell receptor for virus entry", "Hydrolase", "IgE-binding protein", "IgG-binding protein", "Initiation factor", "Integrin", "Ion channel", "Isomerase", "Kinase", "Ligase", "Lyase", "Metalloenzyme inhibitor", "Metalloprotease", "Methyltransferase", "Mitogen", "Monooxygenase", "Motor protein", "Multifunctional enzyme", "Muscle protein", "Myosin", "Nuclease", "Nucleotidyltransferase", "Oxidoreductase", "Peroxidase", "Phospholipase A2 inhibitor", "Porin", "Prenyltransferase", "Protease", "Protease inhibitor", "Protein kinase inhibitor", "Protein phosphatase", "Protein phosphatase inhibitor", "Protein synthesis inhibitor", "RNA-binding", "Receptor", "Repressor", "Ribonucleoprotein", "Ribosomal protein", "Rotamase", "Serine esterase", "Serine protease", "Serine protease inhibitor", "Serine/threonine-protein kinase", "Signal transduction inhibitor", "Thiol protease", "Thiol protease inhibitor", "Threonine protease", "Topoisomerase", "Transducer", "Transferase", "Translational shunt", "Translocase", "Tumor antigen", "Tyrosine-protein kinase", "Voltage-gated channel", "rRNA-binding", "tRNA-binding"], "available_proteins": ["AACS", "AAMP", "AARS", "AARS2", "AASDHPPT", "AASS", "ABCB1", "ABCC1", "ABCE1", "ABCF1", "ABHD10", "ABHD12", "ABHD14B", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADSL", "ADSS", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AHCTF1", "AHCY", "AHCYL1", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AK1", "AK2", "AK3", "AK6", "AKAP1", "AKAP12", "AKAP8", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG5", "ALKBH5", "AMPD2", "ANKHD1", "ANKRD17", "ANLN", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA2", "ANXA3", "APEH", "APEX1", "APLP2", "APOBEC3C", "APRT", "AQR", "ARFGAP1", "ARFGAP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ASAH1", "ASCC3", "ASNA1", "ASNS", "ASPH", "ATAD1", "ATAD2", "ATIC", "ATP11C", "ATP13A1", "ATP1A1", "ATP2A2", "ATP2B1", "ATP5B", "ATP6V1A", "ATP6V1B2", "ATP6V1E1", "B3GALT6", "B4GAT1", "BABAM2", "BAG6", "BANF1", "BAZ1B", "BCLAF1", "BCOR", "BCS1L", "BDH2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BPNT1", "BPTF", "BRD1", "BRD2", "BSG", "BTF3", "BUB1B", "BZW1", "BZW2", "C12orf43", "CACNA2D1", "CAD", "CALD1", "CALR", "CAMK2G", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASK", "CAST", "CBR1", "CBX3", "CBX8", "CCAR1", "CCAR2", "CCDC47", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDC37", "CDC42", "CDC5L", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDKAL1", "CDKN2AIP", "CDS2", "CEBPZ", "CELF1", "CENPF", "CEP55", "CEPT1", "CERS2", "CFDP1", "CFL1", "CFL2", "CHAF1A", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD7", "CHEK2", "CHKA", "CHORDC1", "CHTF18", "CHTOP", "CIRBP", "CKB", "CKMT1A*", "CLIC1", "CLIC4", "CLPB", "CLPP", "CLPTM1", "CLPX", "CLUH", "CMAS", "CMPK1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNOT1", "CNOT7", "CNOT9", "CNP", "COLEC12", "COLGALT1", "COMT", "COPA", "COPS5", "CORO1C", "COTL1", "COX2", "COX4I1", "CPD", "CPNE1", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF7", "CPT2", "CPVL", "CRYZ", "CS", "CSDE1", "CSK", "CSNK1A1", "CSNK2A2", "CSRP2", "CSTB", "CTBP1", "CTBP2", "CTCF", "CTNNB1", "CTPS1", "CTSA", "CTSB", "CTSC", "CUL5", "CXorf57", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBR1", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCD", "DCPS", "DCTPP1", "DCXR", "DDAH2", "DDB1", "DDI2", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DHCR24", "DHCR7", "DHFR", "DHRS13", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX34", "DHX35", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIAPH1", "DIEXF", "DIMT1", "DIS3", "DKC1", "DLAT", "DLD", "DLST", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC17", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DOCK1", "DOCK7", "DOHH", "DPH5", "DPM1", "DPP3", "DPYSL2", "DR1", "DRG1", "DRG2", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "DYNLL2", "DYNLT1", "EARS2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDF1", "EDRF1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1G", "EEF2", "EFL1", "EHMT1", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMOD2", "ELP3", "EMD", "EMG1", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPHX1", "EPHX2", "EPRS", "ERAL1", "ERAP1", "ERAP2", "ERCC2", "ERCC3", "ERCC4", "ERCC6L", "ERI1", "ERMP1", "ERO1A", "ERP44", "ESD", "ETFDH", "EWSR1", "EXO1", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "F11R", "FAH", "FAHD1", "FAM120A", "FAM208A", "FAM213A", "FANCI", "FAR1", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD5", "FBL", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FH", "FIP1L1", "FKBP10", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FMR1", "FN3KRP", "FNTA", "FNTB", "FOXRED1", "FRG1", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "FYTTD1", "G3BP1", "G3BP2", "G6PD", "GAA", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCDH", "GCN1", "GDI1", "GDI2", "GDPD1", "GEMIN5", "GFM1", "GFPT1", "GGCT", "GGCX", "GGH", "GLA", "GLB1", "GLB1L2", "GLDC", "GLO1", "GLS", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNG5", "GNPAT", "GNPDA1", "GNS", "GOT1", "GOT2", "GPD1L", "GPD2", "GPHN", "GPI", "GPX8", "GRHPR", "GRPEL1", "GRSF1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GTF2F1", "GTF2I", "GTF3C1", "GTF3C3", "GTF3C4", "GTF3C5", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDLBP", "HEATR1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HEXIM1", "HIBADH", "HIBCH", "HINT2", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGA2", "HMGB1", "HMGB2", "HMGB3", "HMGCR", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HP1BP3", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA14", "HSPA1B", "HSPA2", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPD1", "HSPE1", "HTATSF1", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDI1", "IFIT5", "IFNGR1", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "IQGAP1", "IQGAP2", "IQSEC1", "IRF2BPL", "IRS4", "ISYNA1", "ITCH", "ITGB1", "ITPA", "ITPK1", "IVD", "JMJD6", "KARS", "KAT7", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA1147", "KIF11", "KIF14", "KIF18A", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KMT2A", "KRR1", "KYAT3", "LAMP1", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LASP1", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD3", "LGALS3", "LIG3", "LIMA1", "LIN28B", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LRP1", "LRPAP1", "LRPPRC", "LRSAM1", "LRWD1", "LSM14A", "LSM2", "LSM4", "LSM6", "LSM7", "LSM8", "LSS", "LTA4H", "LUC7L3", "LYAR", "LYPLA1", "M6PR", "MACF1", "MAGED2", "MANBA", "MANF", "MAP2K1", "MAP2K4", "MAPK1", "MAPK14", "MARC1", "MARC2", "MARCKS", "MARCKSL1", "MARS", "MAT2A", "MATR3", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MDH1", "MDH2", "MDN1", "ME2", "MECP2", "MED24", "MED4", "METTL13", "METTL16", "MFN1", "MFN2", "MGAT1", "MGEA5", "MGME1", "MGST3", "MID1", "MIF", "MINDY3", "MIPEP", "MKI67", "MKRN2", "MMS19", "MOGS", "MORC2", "MORF4L1", "MORF4L2", "MOV10", "MPG", "MPHOSPH10", "MPHOSPH8", "MPI", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL47", "MRPL51", "MRPL53", "MRPL9", "MRPS11", "MRPS15", "MRPS17", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MTA1", "MTA2", "MTAP", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTR", "MUT", "MYBBP1A", "MYCBP2", "MYG1", "MYH10", "MYH9", "MYL6", "MYL6B", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA40", "NAA50", "NAGLU", "NAMPT", "NANS", "NAP1L4", "NARS", "NAT10", "NAXE", "NCBP3", "NCL", "NCOA5", "ND1", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS7", "NDUFV2", "NEDD4L", "NEK9", "NELFCD", "NELFE", "NF1", "NHP2", "NIFK", "NIP7", "NIPBL", "NIT2", "NKRF", "NKTR", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOL11", "NOL6", "NOL8", "NOL9", "NONO", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NOVA2", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUCB1", "NUCB2", "NUDCD1", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUFIP2", "NUP153", "NUP98", "NXF1", "NXN", "OAT", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC3", "OSGEP", "OTUB1", "OXCT1", "P3H1", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PAPSS2", "PARK7", "PARN", "PARP1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCK2", "PCMT1", "PCNA", "PCYOX1", "PDCD4", "PDCL3", "PDE12", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDXDC1", "PEBP1", "PECR", "PELP1", "PEPD", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB2", "PHC2", "PHF5A", "PHF6", "PHGDH", "PI4K2A", "PI4KA", "PIGK", "PIK3C2A", "PIK3R4", "PIN4", "PIR", "PITHD1", "PITRM1", "PKM", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLK1", "PLOD1", "PLOD2", "PLS1", "PLS3", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "POGZ", "POLA1", "POLD1", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR2B", "POLR2G", "POLR2H", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "PON2", "POP1", "POP7", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL4", "PPM1F", "PPM1G", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R8", "PPP3CA", "PPP5C", "PPP6C", "PPT1", "PPT2", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA1", "PRKACA", "PRKCB", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF31", "PRPF4B", "PRPF8", "PRSS3", "PSAT1", "PSIP1", "PSMB5", "PSMB6", "PSMB7", "PSMD10", "PSMD14", "PSME4", "PSMG1", "PSPC1", "PTBP1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS7", "PYCR1", "PYCR2", "PYGB", "PYGL", "PYM1", "QARS", "QKI", "QPRT", "QSOX2", "RAB10", "RAB18", "RAB1A", "RAB23", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD50", "RALA", "RALY", "RANBP1", "RANBP2", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPJ", "RCC1", "RCC2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "REXO2", "REXO4", "RFC1", "RFC3", "RHOT1", "RHOT2", "RIC8A", "RIDA", "RIPK1", "RNASEH2A", "RNASET2", "RNF14", "RNF2", "RNF20", "RNF219", "RNF40", "RNMT", "RNPEP", "RNPS1", "ROCK1", "RPA1", "RPA2", "RPF1", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPP30", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RREB1", "RRM1", "RRM2", "RRP1B", "RRP8", "RRP9", "RSF1", "RTCB", "RTRAF", "RUVBL1", "RUVBL2", "SACM1L", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAP18", "SAP30BP", "SARNP", "SARS", "SARS2", "SART3", "SCAF1", "SCAF4", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SDE2", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC14L2", "SEC61A1", "SEC63", "SELENBP1", "SENP3", "SEPHS1", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETDB1", "SF1", "SF3B1", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SGPL1", "SGTA", "SHMT2", "SHTN1", "SIGMAR1", "SIN3A", "SIRT1", "SIRT2", "SKIV2L", "SKIV2L2", "SLC1A5", "SLC27A4", "SLC7A1", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMCHD1", "SMN1*", "SMPD4", "SMYD3", "SND1", "SNRNP200", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SOD2", "SON", "SORD", "SORT1", "SPCS2", "SPCS3", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SRCAP", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSRP1", "STAT1", "STAT3", "STAU1", "STMN1", "STRBP", "STT3A", "STT3B", "STUB1", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF6", "SUZ12", "SWAP70", "SYNCRIP", "SYNE2", "TAF15", "TALDO1", "TAMM41", "TAOK1", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D15", "TBC1D4", "TBC1D8B", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBK1", "TCEA1", "TCERG1", "TCF20", "TCF25", "TCP1", "TECR", "TERF2IP", "TFAM", "TFB1M", "TFRC", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "TIA1", "TIAL1", "TIGAR", "TIMM50", "TJP1", "TK1", "TKT", "TMCO1", "TMEM109", "TMOD3", "TMPPE", "TMTC3", "TOMM22", "TOMM34", "TOMM40", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOX4", "TP53", "TP53BP1", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TRA2A", "TRA2B", "TRAP1", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRMT10C", "TRMT11", "TRMT1L", "TRMT2A", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSNAX", "TSR3", "TST", "TSTA3", "TTLL4", "TTYH3", "TUFM", "TWF1", "TWNK", "TXNDC12", "TXNRD1", "TXNRD2", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBE2K", "UBE2L3", "UBE2M", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBLCP1", "UBR1", "UBR4", "UBR5", "UBTF", "UCHL5", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCRFS1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP33", "USP36", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP3", "UTRN", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIRMA", "VPS4A", "VPS4B", "VRK1", "WARS", "WARS2", "WDHD1", "WDR1", "WDR18", "WDR43", "WDR5", "WNK1", "WTAP", "XPNPEP1", "XPNPEP3", "XPO1", "XPO5", "XPOT", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YKT6", "YLPM1", "YME1L1", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "ZADH2", "ZBTB10", "ZC3H14", "ZC3H7A", "ZC3HAV1", "ZCCHC3", "ZCRB1", "ZFR", "ZMPSTE24", "ZNF207", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF638", "ZNF687", "ZRANB2"], "leading_proteins": ["AARS2", "ABCB1", "ABHD10", "ACAT2", "ACOX3", "ACP2", "ACP6", "AGL", "AGPAT1", "AKT2", "ANP32A", "APOBEC3C", "ARMT1", "ASCC3", "ATP13A1", "ATP6V1E1", "B4GAT1", "BABAM2", "BAG6", "BIRC6", "BUB1B", "CARM1", "CASK", "CCNB1", "CDK11B", "CDK12", "CDK4", "CHCHD3", "CIRBP", "CLPP", "COMT", "CPD", "CPNE1", "CPT2", "CSNK1A1", "CSTB", "CTBP1", "CTSA", "CTSB", "CYP51A1", "DCPS", "DCTPP1", "DHCR24", "DHFR", "DHX40", "DNAJC2", "DOHH", "ECE1", "ELP3", "EPHX1", "ERAP1", "ERAP2", "EWSR1", "EXO1", "F11R", "FAM208A", "FCGRT", "FMR1", "FNTB", "FOXRED1", "FUCA2", "GAA", "GAK", "GBA", "GGH", "GLA", "GLB1", "GLB1L2", "GLDC", "GM2A", "GPX8", "GSTO1", "GUSB", "HADH", "HDAC2", "HEXA", "HEXIM1", "HM13", "HMCES", "HMOX1", "HMOX2", "HNRNPDL", "HNRNPK", "ICMT", "IDH1", "IDH2", "IFNGR1", "IGF2R", "KDM1B", "KDM5A", "KDSR", "KMT2A", "LBR", "LNPEP", "LPCAT1", "LRWD1", "LTA4H", "MAP2K1", "MAP2K4", "MAPK14", "MARC1", "METTL13", "MGEA5", "MGME1", "MINDY3", "MSMO1", "MTAP", "MTMR6", "MTOR", "MYL6", "MYL6B", "NAA40", "NAGLU", "NAMPT", "NCOA5", "NDUFS2", "NELFCD", "NLN", "NMT1", "NPC1", "NPEPPS", "NSD2", "NSUN2", "NT5C3B", "NT5DC1", "NTMT1", "NUCB2", "OLA1", "OTUB1", "P3H1", "P4HA1", "PANK4", "PBK", "PCYOX1", "PEBP1", "PECR", "PGRMC1", "PGRMC2", "PIR", "PITRM1", "PLA2G15", "PLBD2", "PLD3", "PLD6", "PON2", "PPP1CA", "PPP1R8", "PPT1", "PPT2", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX6", "PRKAA1", "PRKDC", "PSMB5", "PSMB6", "PSMB7", "PTGR1", "PTPN11", "PUF60", "RAD21", "RBM14", "RBMX", "RNASET2", 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sha256:c2a9f6d484b3dc0cde191913f3bab22db4e1e80343cfae0b91e9fea447679441 +size 77169 diff --git a/protein_atlas_protein_class/df_merge.tsv b/protein_atlas_protein_class/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..347a25d71e5c4bb6eb2fcb896d07951387760b10 --- /dev/null +++ b/protein_atlas_protein_class/df_merge.tsv @@ -0,0 +1,3 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 +Predicted membrane proteins 123 472 4.690743230968143 2.722144115896441e-06 204.61650485436897 563.8058252427185 3.080866334016093 0.3028099075873978 81.17076282318972 73.52280648113661 4.068861305085399 0.4187410497068249 0.0018861140691706 0.0070708277230661 0.000261198928348 2.3356941928226868e-05 0.0008230077937979 +Predicted secreted proteins 18 50 2.6199474982965296 0.0087943305065152 15.29368932038835 51.737864077669904 1.393291060716792 0.256881456821794 5.463351773637434 6.9884942404294375 1.5049506819867255 0.3173597508227758 0.0102008762297827 0.0099079782805238 0.004290448003007 0.0134743216847268 0.0115505358368237 diff --git a/protein_atlas_protein_class/metrics.json b/protein_atlas_protein_class/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..04125dbb2901f5c3118cffdc7695c3c160a9cb28 --- /dev/null +++ b/protein_atlas_protein_class/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2812, + "annotations_size": 20, + "title": "Average number of proteins per term", + "value": 456.05 +} \ No newline at end of file diff --git a/protein_atlas_protein_class/paths.json b/protein_atlas_protein_class/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..5c51772fea1d08724574e6076d81db79917eb85b --- /dev/null +++ b/protein_atlas_protein_class/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_protein_class/fragment/C428/C428_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_protein_class/result.tsv b/protein_atlas_protein_class/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..b3c140ad82c72c1358a618554885a74b3ee7a465 --- /dev/null +++ b/protein_atlas_protein_class/result.tsv @@ -0,0 +1,15 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Predicted membrane proteins 0.4144375035823342 4.690743230968143 2.722144115896441e-06 5.444147442791214e-05 2.722144115897441e-05 472 Q9NS69,Q9Y282,Q99595,O60830,Q15392,Q70HW3,Q5BJF2,Q96ES6,Q8NHS3,Q567V2,Q9UIQ6,P53985,Q96G23,P30519,Q8WTV0,O43676,Q9Y487,Q9H061,Q8IXU6,O15173,Q5SR56,Q9NPR9,O75844,Q8N511,Q92804,Q16850,Q5VW38,O60725,Q8IV08,O43772,P09601,O15118,Q14108,Q8NCC3,P42892,Q9HD20,Q86XL3,Q06481,Q06136,O75306,Q8NBX0,O14936,P43307,Q9Y2R0,O43169,P15260,Q9C0H2,Q9H1E5,O95197,Q15800,O75964,Q9BQE5,P04439,P55899,Q8N2A8,Q9Y287,P01889,Q93050,O15260,Q6ZT21,Q9UBX3,Q96SK2,Q9NR28,O00461,O15270,Q9P2W9,Q9Y619,P11117,P08183,Q8NE01,Q9Y679,Q14739,Q07820,P42858,Q9Y6C9,Q96PC5,Q15904,Q9Y624,Q7L0J3,Q9NQC3,Q9HD45,O75976,O43493,Q3SXM5,O00264,Q8NF37,Q96A26,Q9BZF1,O95772,P62942,Q15629,Q6P4Q7,Q9Y262,P51003,P10321,Q8TCT9,P11717,Q13505,Q99523,Q96S97,Q92896,P35573,P35080,Q99943,Q07954,P42356,O43657,Q8TB61,Q96N66,Q9H4I3,Q01650,P50402,P04844,Q9UKR5,Q9HDC9,Q96FV9,P51648,Q12907,P37268,Q6RW13,P31350,O15344,Q969M3 123 +Predicted secreted proteins 0.5210544387706468 2.6199474982965296 0.0087943305065152 0.1619391578280837 0.0439716525325761 50 O60888,Q9HB40,O00584,Q9UMX5,O75718,Q9Y287,P14174,Q8WXW3,Q15165,Q9BTY2,P04083,P43490,Q8WUJ1,Q08380,Q6P179,P80303,Q8IW92,P07858 18 +Candidate cardiovascular disease genes 0.6122102446510778 1.6494648021095009 0.0990524483526138 0.8758375744087499 0.2631023713372588 11 P07858,Q15165 2 +Metabolic proteins 0.2793372130847718 1.6476954447503782 0.099415183282 0.8768335524900739 0.2631023713372588 787 P07099,Q15392,Q70HW3,P42126,Q13126,Q03164,P53985,Q96G23,Q8N4Q0,O60502,P30519,P07858,Q9NVE7,Q86UY6,Q8WTV0,O43676,P49356,Q9Y487,O43924,O43505,P43490,Q9UHG3,O75844,P48735,Q9H2D1,Q9UMR5,P10619,P50897,Q16850,O60725,Q8IV08,P78417,Q9H773,Q92820,O43772,P09601,O15118,P54802,Q8NCC3,P04062,P35790,Q06124,P30419,O14773,P07602,Q15165,Q9Y285,Q06136,O75306,Q8NBX0,O14936,Q9H7Z7,P55735,O75874,Q14914,Q9BTY2,P48449,O96028,P08236,P06865,P36543,Q15800,Q9BY49,O75964,P13674,P16278,Q8N2A8,Q969T7,Q96IJ6,Q93050,P06280,P21266,Q6ZT21,Q9BWD1,O60684,Q9UBX3,P30154,P21912,O15270,Q9NXR7,Q9Y619,P11117,P08183,Q86X55,Q96K76,Q7L7X3,Q14739,P31751,O14976,Q8NFH4,Q15904,P47985,P00374,Q9Y6M9,P17900,P14174,P21964,O15254,Q8N6R0,Q9UPU5,P57740,Q9NR33,P09960,Q8TEY7,Q8NF37,Q9NPH0,P10253,P62942,P51003,Q9HA64,P45985,O43865,P23378,Q9BYW2,Q9Y217,Q16836,Q9H000,Q02750,P35573,P17812,Q9HC38,Q9H7B4,Q99943,P42356,P23786,Q9BYT8,Q96RU2,Q8TB61,P62136,P55786 130 +Transporters 0.3409536983892614 1.4990900279598502 0.1338502782302932 0.9435245884677614 0.2739431852165195 328 P55735,Q70HW3,Q5BJF2,Q9C0H2,P45880,P04083,Q8NHS3,P36543,P53985,P57740,P04439,Q16543,O00505,Q9Y512,Q8WTV0,Q9Y287,Q92973,O00629,P52294,Q93050,Q9BZF1,Q9H061,O15260,Q8IXU6,P62942,Q5SR56,Q15629,Q6P4Q7,O75844,O60684,Q8N511,Q9H2D1,Q9UBX3,P21912,Q5VW38,P11717,O43865,P50995,O43772,Q9UHB9,Q9Y619,Q99523,O15118,Q14108,P08183,O60443,Q8NE01,Q9HD20,P07602,Q8NFH4,Q9Y6C9,Q96PC5,Q15904 53 +Potential drug targets 0.2881608016252304 1.487163655309382 0.1369715926082597 0.947458577912301 0.2739431852165195 427 P07099,Q15392,Q70HW3,Q13126,P48449,O96028,Q8NHS3,P08236,P06865,P36543,Q03164,Q15800,P53985,P07858,P04439,P16278,O00584,Q9Y287,P06280,Q9H061,O75844,Q8N511,Q9H2D1,P10619,P50897,P21912,Q8IV08,O15270,O43772,P09601,Q9Y619,Q5JTZ9,O15118,P54802,Q14108,P11117,P42892,P04062,O60443,Q16740,Q06124,Q32P28,Q14739,O14773,P07602,P31751,Q8NFH4,P28070,Q96PC5,Q15904,Q06136,O75306,O14936 53 +FDA approved drug targets 0.3523739090464959 1.4269173083125632 0.1536037312288478 0.964397966600422 0.2792795113251778 109 P15260,O75874,Q16637,P68371,P21964,P04083,P49721,Q9NR33,P49356,P38435,Q16134,P10253,P62942,P48735,P21283,P31350,P36404,Q16850,P28074,P03886,P20618,Q16836,Q92769,Q02750,Q14534,P00374,P07437,P23786,P42345,Q7L0J3 30 +Enzymes 0.2628765519496706 1.1206099800831346 0.2624539150008231 0.9977312677682556 0.4037752538474202 800 P07099,Q15392,P42126,P42785,Q13126,P49721,Q03164,Q9UIQ6,Q96G23,Q8N4Q0,O60502,P30519,P07858,Q86UY6,Q9HB40,P49356,P28072,P43490,Q9UHG3,O75844,P48735,O95881,P10619,P50897,Q16850,P28074,O60725,Q8IV08,P78417,Q9H773,Q92820,P09601,P54802,Q8NCC3,P42892,P04062,Q9NUJ1,P35790,Q06124,Q32P28,P30419,O14773,P20618,Q15165,Q8NB78,Q9Y285,Q8IX18,P28070,Q06136,O75306,P19474,P60900,O14936,Q9H7Z7,Q96FW1,O75874,Q14914,Q9BTY2,P48449,O96028,P08236,P06865,Q15800,Q9BY49,Q5JRX3,P13674,P16278,O00584,Q969T7,P06280,P21266,Q92696,Q9BWD1,P21912,Q99436,O15270,Q5JTZ9,P11117,P08183,Q86X55,Q96K76,Q9BV86,Q16740,Q7L7X3,Q14739,P31751,O14976,P47985,P00374,P14174,P29375,P21964,O75976,O15254,Q08J23,Q6P179,Q9UPU5,P09960,Q8TEY7,P25788,Q8NF37,Q9BU89,Q9NPH0,P10253,P62942,P49720,P51003,Q8TCT9,Q9HA64,P45985,P23378,Q9BYW2,Q9Y217,Q16836,Q9H000,Q8N3C0,Q02750,P35573,P17812,O00625,Q9H7B4,Q99943,P42356,P23786,Q96C86,Q9BYT8,Q96RU2,Q9NRW3,P62136,P55786 130 +CD markers 0.4733995741371826 1.066138782911251 0.2863609101628532 0.9988262580867644 0.4090870145183618 14 P15260,P11717,Q07954,P08183,Q9Y624 5 +Disease related genes 0.2546251884003916 0.9766549755573554 0.3287399924515055 0.9996550028800408 0.4383199899353407 906 O14646,Q92734,P07099,Q96CU9,Q8TB36,Q99567,Q15392,Q70HW3,Q9Y3I1,Q13363,Q14126,Q10713,Q13126,O75477,Q8NHS3,O75503,P10644,P40855,Q03164,P43243,P53985,P07858,Q6UN15,Q15022,O43676,P46977,Q9Y487,P38435,P27635,O43924,P18074,O95831,O43505,Q9H061,O95470,Q12888,Q16134,Q16204,Q96DH6,Q9H9T3,O75844,P48735,P51114,Q9NQH7,Q8N511,Q9H2D1,P30533,Q92804,Q06330,O14949,P10586,P10619,P50897,O76024,Q8IV08,Q9H3L0,O43772,P09601,O15118,P54802,Q14108,P42892,P04062,O60443,Q06124,Q32P28,O14773,P07602,Q86XL3,P28070,Q15437,Q06136,O75306,Q6DKK2,O14936,Q9Y2R0,P15260,O75874,O14979,P48449,P35637,O96028,P08236,P06865,P36543,Q15800,O95684,P04439,P16278,O00584,Q9Y287,Q96IJ6,P01889,P55795,P06280,P21912,Q15555,Q9NR28,Q969G3,Q8N0X7,O15270,Q9Y619,Q5JTZ9,P61978,P11117,P08183,Q9BW83,Q92733,Q16740,Q14739,P98175,P42858,P31751,Q8NFH4,Q96D71,Q96PC5,Q15904,P47985,P00374,P07437,Q9BVA1,Q9Y6M9,P17900,Q01105,Q96B26,O75718,P68371,P14174,P29375,Q8TD16,P38159,P21964,Q08J23,Q8N6R0,P57740,P22626,Q96BR5,Q9BQP7,Q8IUD2,Q53EZ4,P10253,O95721,Q6P4Q7,Q9UHX1,P10321,Q8WXW3,P50995,Q969T9,Q99523,P23378,Q6PGP7,Q9BYW2,Q6IA86,Q01844,Q06787,Q16836,Q02750,P35573,P17812,Q96PZ0,Q9UBS4,Q07954,P42356,P23786,Q96C86,Q16637,Q13432,P08670,P04066,O60216,Q9UKG1,Q96AY3,Q9NXN4,Q96N66,P07737,P13807,Q9C0B1,P61916,P50402,Q92990,P51648,Q14671,P31483,P37268,O15344,Q9BW27,Q92542,Q15067,Q8IWS0,Q4G0J3,Q12955,P03886,O00116,Q96ST3,Q8N183,Q13501,P78318,Q5M775,P40818,P30153,P04792,Q12769,Q00059,P42345,P13051 205 +Human disease related genes 0.2535959764097781 0.8778852520428972 0.3800059934070479 0.9999295712752152 0.4745898112431825 819 O14646,Q92734,P07099,Q96CU9,Q8TB36,Q99567,Q15392,Q70HW3,Q9Y3I1,Q13363,Q14126,Q10713,O75477,Q8NHS3,O75503,P10644,P40855,Q03164,P43243,P53985,Q9Y6M1,P07858,O43676,P46977,Q9Y487,P38435,P27635,O43924,P18074,O95831,O43505,Q9H061,O95470,Q16134,Q16204,O75844,P48735,Q9NQH7,P30533,Q8N511,Q06330,O14949,O76024,P10619,P50897,Q8IV08,Q9H3L0,O43772,P09601,O15118,P54802,Q14108,P42892,P04062,O60443,Q06124,Q32P28,O14773,P07602,Q9Y285,Q86XL3,Q15437,Q06136,O75306,Q6DKK2,O14936,Q9H7Z7,P15260,O75874,O14979,P48449,P35637,O96028,P08236,P06865,P36543,Q15800,Q9BQE5,P04439,P16278,O00584,Q9Y287,Q96IJ6,P01889,P55795,P06280,Q9UBX3,P21912,Q15555,Q9NR28,Q969G3,Q8N0X7,O15270,Q9Y619,Q5JTZ9,P61978,P11117,P08183,Q9BW83,Q16740,Q14739,P98175,P42858,P31751,Q8NFH4,Q96D71,P00374,P07437,Q9BVA1,Q9Y6M9,P17900,Q01105,Q96B26,O75718,P68371,P14174,Q8TD16,P38159,P21964,Q08J23,P57740,P22626,Q96BR5,Q9BQP7,Q53EZ4,P10253,O95721,Q6P4Q7,Q9UHX1,P10321,Q8WXW3,P50995,Q969T9,P23378,Q6PGP7,Q9BYW2,Q6IA86,Q06787,Q16836,Q02750,P35573,P17812,Q96PZ0,Q9UBS4,P42356,P23786,Q96C86,Q16637,P08670,P04066,O60216,Q9UKG1,Q96AY3,Q9NXN4,Q96N66,P07737,P13807,Q9C0B1,P61916,P50402,Q92990,P51648,Q14671,P31483,O15344,Q9BW27,Q92542,Q15067,Q8IWS0,Q4G0J3,Q12955,P03886,O00116,Q96ST3,Q8N183,Q13501,P78318,P40818,P30153,P04792,Q12769,Q00059,P42345,P13051 184 +Transcription factors 0.3458174705343566 0.835562025512234 0.4034013395567051 0.999967367865833 0.4745898112431825 49 P67809,P16989,Q969G3,O96028,Q03164,Q99543 6 +Cancer-related genes 0.2999331631212993 0.7729859710101383 0.4395306832959631 0.9999906451498244 0.4883674258844034 341 Q92734,P07099,Q99595,O00743,P10644,Q03164,P62993,Q14258,P07858,Q6UN15,Q16539,Q15022,P46977,P27635,P18074,Q14247,Q12888,P43490,Q16204,Q96DH6,P48735,P80303,Q92804,P09601,Q06124,Q06136,O75874,P35637,O96028,P08236,Q9BQE5,O95684,P04439,P01889,P21266,P21912,Q969G3,Q5JTZ9,P08183,Q86X55,Q99543,Q92733,P67809,P98175,Q07820,P31751,Q08380,P00374,Q01105,P14174,P29375,P38159,P04083,P22626,P09960,Q16543,Q8IUD2,P45985,P11717,P50995,Q14847,Q9BYW2,Q01844,Q02750,Q9H7B4,O60216,P11940,Q96PU8,Q8IWS0,Q12955,Q96ST3,Q8WYA6,P17931,Q92769,P40818,P30153,P04792,Q8IXJ6,P42345 79 +RAS pathway related proteins 0.3044271595884042 0.192241429762467 0.8475530948205727 1.0 0.8475530948205727 20 P31751,Q02750,P11233,Q06124 4 diff --git a/protein_atlas_protein_class/selections.json b/protein_atlas_protein_class/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..dd4a095dbcf029e0b64fe0c6763f51c7a86af574 --- /dev/null +++ b/protein_atlas_protein_class/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Blood group antigen proteins", "CD markers", "Cancer-related genes", "Candidate cardiovascular disease genes", "Citric acid cycle related proteins", "Disease related genes", "Enzymes", "FDA approved drug targets", "Human disease related genes", "Metabolic proteins", "Plasma proteins", "Potential drug targets", "Predicted intracellular proteins", "Predicted membrane proteins", "Predicted secreted proteins", "RAS pathway related proteins", "RNA polymerase related proteins", "Ribosomal proteins", "Transcription factors", "Transporters"], "available_proteins": ["AAAS", "AACS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASDHPPT", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD12", "ABHD14B", "ABRAXAS2", "ACAA2", "ACACA", "ACACB", "ACAD11", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACP2", "ACP6", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ACTR3", "ADAR", "ADD1", "ADD3", "ADH5", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AGTRAP", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK6", "AKAP1", "AKAP12", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG5", "ALKBH5", "AMOT", "AMPD2", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKHD1", "ANKLE2", "ANKRD17", "ANLN", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP1M1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP2S1", "AP3B1", "AP3D1", "AP3M1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOBEC3C", "APOL2", "APOOL", "APPL1", "APRT", "AQR", "ARCN1", "ARF4", "ARF5", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARHGEF2", "ARHGEF7", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6", "ARL6IP1", "ARL6IP5", "ARL8A", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ARPC4", "ASAH1", "ASCC1", "ASCC3", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATG9A", "ATIC", "ATP11C", "ATP13A1", "ATP1A1", "ATP1B1", "ATP1B3", "ATP2A2", "ATP2B1", "ATP5A1", "ATP5B", "ATP5C1", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V0D1", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "B3GALT6", "B4GAT1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1A", "BAZ1B", "BCAP31", "BCAS2", "BCCIP", "BCL2L13", "BCLAF1", "BCOR", "BCS1L", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRD1", "BRD2", "BRI3BP", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C11orf58", "C12orf43", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C2orf49", "CAB39", "CACNA2D1", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASK", "CAST", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC134", "CCDC137", "CCDC22", "CCDC43", "CCDC47", "CCDC58", "CCDC6", "CCDC8", "CCDC86", "CCDC93", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD47", "CDC123", "CDC16", "CDC23", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA2", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDKAL1", "CDKN2AIP", "CDS2", "CDV3", "CEBPZ", "CELF1", "CENPF", "CENPI", "CEP170", "CEP44", "CEP55", "CEPT1", "CERS2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD7", "CHEK2", "CHERP", "CHID1", "CHKA", "CHMP2A", "CHMP2B", "CHMP4B", "CHMP5", "CHMP6", "CHMP7", "CHORDC1", "CHTF18", "CHTOP", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CKAP2", "CKAP2L", "CKAP4", "CKAP5", "CKB", "CKMT1A*", "CLASP1", "CLCN3", "CLIC1", "CLIC4", "CLINT1", "CLN5", "CLNS1A", "CLPB", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG2", "COG7", "COIL", "COLEC12", "COLGALT1", "COMMD4", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPG2", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7B", "COPS8", "COPZ1", "CORO1C", "COTL1", "COX15", "COX2", "COX4I1", "COX5A", "COX5B", "COX6C", "COX7C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF3", "CPSF7", "CPT2", "CPVL", "CRKL", "CRNKL1", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSNK2A2", "CSNK2B", "CSRP2", "CSTB", "CSTF1", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CUTA", "CWC15", "CWC22", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYFIP1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBR1", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCXR", "DDA1", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DHCR24", "DHCR7", "DHFR", "DHRS13", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX34", "DHX35", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DIDO1", "DIEXF", "DIMT1", "DIP2B", "DIS3", "DKC1", "DLAT", "DLD", "DLGAP5", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC13", "DNAJC17", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOCK7", "DOHH", "DPH5", "DPM1", "DPP3", "DPYSL2", "DR1", "DRG1", "DRG2", "DSG2", "DSP", "DSTN", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "DYNLL2", "DYNLT1", "EARS2", "EBNA1BP2", "ECE1", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC4", "EDF1", "EDRF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3F", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMOD2", "ELOB", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMC1", "EMC2", "EMC4", "EMC7", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX1", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERCC6L", "ERG28", "ERGIC1", "ERGIC2", "ERGIC3", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERMP1", "ERO1A", "ERP29", "ERP44", "ESD", "ESF1", "ESS2", "ESYT1", "ETF1", "ETFA", "ETFB", "ETFDH", "EWSR1", "EXO1", "EXOC5", "EXOC6", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC6", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120A", "FAM162A", "FAM177A1", "FAM208A", "FAM208B", "FAM213A", "FAM49B", "FAM8A1", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP2", "FARSA", "FARSB", "FASN", "FASTKD5", "FBL", "FBXO7", "FCGRT", "FDFT1", "FDPS", "FDXR", "FECH", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP10", "FKBP1A", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNDC3A", "FNTA", "FNTB", "FOXRED1", "FRG1", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUCA2", "FUS", "FXR1", "FXR2", "FYTTD1", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT1", "GALNT2", "GALNT7", "GAMT", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBA", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDAP2", "GDI1", "GDI2", "GDPD1", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA2", "GGCT", "GGCX", "GGH", "GHDC", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLA", "GLB1", "GLB1L2", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX", "GLRX3", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMDS", "GMFB", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNG5", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPAT", "GNPDA1", "GNS", "GOLGB1", "GOLIM4", "GOLM1", "GORASP2", "GOT1", "GOT2", "GPAA1", "GPD1L", "GPD2", "GPHN", "GPI", "GPR107", "GPR108", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSDME", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GSTO1", "GTF2F1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP10", "GTPBP3", "GTPBP4", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HAUS5", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HEBP2", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXB", "HEXIM1", "HGS", "HIBADH", "HIBCH", "HINT2", "HIRIP3", "HIST1H1C", "HIST1H1D", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLA-B", "HLA-C", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGA2", "HMGB1", "HMGB2", "HMGB3", "HMGCR", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPF1", "HPRT1", "HS2ST1", "HSD17B10", "HSD17B11", "HSD17B12", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA12A", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPB11", "HSPBP1", "HSPD1", "HSPE1", "HSPH1", "HTATSF1", "HTT", "HUS1", "HUWE1", "HYOU1", "IARS", "IARS2", "IBA57", "ICE1", "ICMT", "IDE", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDI1", "IFIT5", "IFNGR1", "IFT27", "IGBP1", "IGF1R", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INCENP", "INTS1", "INTS13", "INTS14", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQSEC1", "IRF2BPL", "IRS4", "ISOC1", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITM2B", "ITPA", "ITPK1", "IVD", "IWS1", "JAGN1", "JMJD6", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KDSR", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0100", "KIAA0319L", "KIAA0368", "KIAA1147", "KIAA2013", "KIF11", "KIF14", "KIF18A", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIFBP", "KIN", "KLC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "LAMP1", "LAMTOR1", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LGALS3BP", "LIG3", "LIMA1", "LIN28B", "LLGL1", "LMAN1", "LMAN2", "LMNA", "LMNB1", "LMNB2", "LNPEP", "LONP1", "LPCAT1", "LPGAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRSAM1", "LRWD1", "LSM12", "LSM14A", "LSM2", "LSM4", "LSM6", "LSM7", "LSM8", "LSS", "LTA4H", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LZTFL1", "M6PR", "MACF1", "MAD2L1", "MAGED2", "MAGT1", "MAK16", "MANBA", "MANF", "MAP1B", "MAP2K1", "MAP2K4", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARC2", "MARCKS", "MARCKSL1", "MARS", "MAT2A", "MAT2B", "MATR3", "MAU2", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MDC1", "MDH1", "MDH2", "MDN1", "ME2", "MECP2", "MED24", "MED4", "METTL13", "METTL16", "MFAP1", "MFF", "MFN1", "MFN2", "MFSD10", "MFSD14B", "MFSD3", "MFSD5", "MFSD8", "MGAT1", "MGEA5", "MGME1", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MIPEP", "MKI67", "MKRN2", "MLEC", "MMADHC", "MMS19", "MOB4", "MOGS", "MORC2", "MORF4L1", "MORF4L2", "MOV10", "MPDU1", "MPG", "MPHOSPH10", "MPHOSPH8", "MPI", "MPP2", "MPP6", "MPP7", "MPRIP", "MPST", "MPV17L2", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL13", "MRPL14", "MRPL15", "MRPL17", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL24", "MRPL28", "MRPL3", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL47", "MRPL51", "MRPL53", "MRPL9", "MRPS11", "MRPS15", "MRPS17", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS30", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH1", "MTCH2", "MTDH", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTMR6", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MUT", "MXRA7", "MYADM", "MYBBP1A", "MYCBP", "MYCBP2", "MYDGF", "MYG1", "MYH10", "MYH9", "MYL6", "MYL6B", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NAE1", "NAGLU", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NCAPD2", "NCAPD3", "NCAPG", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "ND1", "NDC1", "NDRG3", "NDUFA10", "NDUFA13", "NDUFA4", "NDUFA5", "NDUFA7", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFB10", "NDUFB3", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS6", "NDUFS7", "NDUFV2", "NECAP2", "NEDD4L", "NEFM", "NEK9", "NELFCD", "NELFE", "NENF", "NF1", "NFATC2IP", "NHLRC2", "NHP2", "NIFK", "NIP7", "NIPBL", "NIPSNAP1", "NIPSNAP2", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NOVA2", "NPC1", "NPC2", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NT5C2", "NT5C3B", "NT5DC1", "NT5DC2", "NTMT1", "NTPCR", "NUB1", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDT1", "NUDT12", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP160", "NUP188", "NUP205", "NUP210", "NUP214", "NUP37", "NUP43", "NUP50", "NUP54", "NUP58", "NUP62", "NUP85", "NUP88", "NUP93", "NUP98", "NUPL2", "NUTF2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "OXCT1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK1IP1", "PAK2", "PALD1", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PAPSS2", "PARK7", "PARN", "PARP1", "PAWR", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCCB", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PCYOX1", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDE12", "PDE6D", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PDZD11", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN4", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGAM1", "PGAM5", "PGD", "PGK1", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF3", "PHF5A", "PHF6", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PIBF1", "PICALM", "PIGK", "PIGS", "PIGT", "PIK3C2A", "PIK3R4", "PIN4", "PIR", "PITHD1", "PITPNB", "PITRM1", "PKM", "PKN2", "PLA2G15", "PLAA", "PLBD2", "PLCG1", "PLD3", "PLD6", "PLEC", "PLIN3", "PLK1", "PLOD1", "PLOD2", "PLRG1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "PON2", "POP1", "POP7", "POR", "PPA1", "PPA2", "PPAN", "PPAT", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL4", "PPM1F", "PPM1G", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4R3A", "PPP5C", "PPP6C", "PPP6R3", "PPT1", "PPT2", "PRC1", "PRCC", "PRCP", "PRDX2", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PREPL", "PRIM1", "PRIM2", "PRKAA1", "PRKACA", "PRKAG1", "PRKAR1A", "PRKAR2A", "PRKCB", "PRKCSH", "PRKDC", "PRMT1", "PRMT3", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38A", "PRPF38B", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PRSS3", "PRTFDC1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA2", "PSMA3", "PSMA4", "PSMA5", "PSMA6", "PSMA7", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD2", "PSMD3", "PSMD6", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSPC1", "PTBP1", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR1", "PTGR2", "PTK7", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PURA", "PUS7", "PWP1", "PWP2", "PWWP2A", "PXMP2", "PYCR1", "PYCR2", "PYGB", "PYGL", "PYM1", "QARS", "QKI", "QPRT", "QSOX2", "RAB10", "RAB13", "RAB14", "RAB18", "RAB1A", "RAB21", "RAB23", "RAB2A", "RAB35", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB4A", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RABGGTA", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPJ", "RCC1", "RCC2", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH11", "RDH13", "RDX", "RECQL", "REEP5", "REPS1", "RER1", "RETREG3", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOG", "RHOT1", "RHOT2", "RIC8A", "RIDA", "RIF1", "RIPK1", "RMDN1", "RNASEH2A", "RNASEH2B", "RNASET2", "RNF14", "RNF2", "RNF20", "RNF219", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "ROCK1", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL15", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL36", "RPL36A", "RPL37", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS15A", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPS9", "RPSA", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RSU1", "RTCB", "RTFDC1", "RTN3", "RTN4", "RTN4IP1", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SBNO1", "SCAF1", "SCAF11", "SCAF4", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCFD1", "SCML2", "SCO1", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SCYL2", "SDAD1", "SDE2", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC13", "SEC14L2", "SEC16A", "SEC22B", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SEH1L", "SELENBP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHMT2", "SHTN1", "SIGMAR1", "SIL1", "SIN3A", "SIRT1", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC1A5", "SLC25A1", "SLC25A10", "SLC25A11", "SLC25A12", "SLC25A13", "SLC25A15", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A21", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC2A1", "SLC30A7", "SLC35B2", "SLC35F2", "SLC38A1", "SLC3A2", "SLC7A1", "SLC7A5", "SLC9A3R1", "SLC9A6", "SLFN11", "SLIRP", "SLIT2", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD1", "SNRPD2", "SNRPD3", "SNRPE", "SNU13", "SNW1", "SNX1", "SNX2", "SNX27", "SNX3", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SORT1", "SPAG5", "SPAG9", "SPART", "SPC24", "SPC25", "SPCS2", "SPCS3", "SPECC1", "SPECC1L", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SPTLC2", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRFBP1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRP72", "SRP9", "SRPK1", "SRPRA", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STIP1", "STMN1", "STOML2", "STRAP", "STRBP", "STT3A", "STT3B", "STUB1", "STX12", "STX18", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SV2A", "SWAP70", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TAB1", "TACC3", "TAF15", "TAF2", "TAF5", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TAOK1", "TARDBP", "TARS", "TARS2", "TBC1D10B", "TBC1D15", "TBC1D4", "TBC1D8B", "TBC1D9B", "TBCA", "TBCB", "TBCD", "TBCE", "TBK1", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCF25", "TCOF1", "TCP1", "TECR", "TELO2", "TERF2IP", "TES", "TEX10", "TFAM", "TFB1M", "TFG", "TFIP11", "TFRC", "TGOLN2", "THEM6", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "TIA1", "TIAL1", "TIGAR", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TJP1", "TK1", "TKT", "TLN1", "TM9SF2", "TM9SF3", "TM9SF4", "TMA16", "TMCO1", "TMED10", "TMED2", "TMED4", "TMED5", "TMED7", "TMED9", "TMEM109", "TMEM115", "TMEM126A", "TMEM14C", "TMEM167A", "TMEM192", "TMEM199", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM230", "TMEM259", "TMEM33", "TMEM43", "TMEM65", "TMEM97", "TMOD3", "TMPPE", "TMTC3", "TMX1", "TMX2", "TMX4", "TNPO1", "TNPO3", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOX4", "TP53", "TP53BP1", "TP53BP2", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP1", "TPP2", "TPR", "TPRKB", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAM1", "TRAP1", "TRAPPC11", "TRAPPC4", "TRAPPC5", "TRAPPC8", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMT11", "TRMT112", "TRMT1L", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSNAX", "TSPAN6", "TSPYL1", "TSR1", "TSR3", "TST", "TSTA3", "TTC1", "TTC19", "TTC21B", "TTC26", "TTC27", "TTC37", "TTC38", "TTC4", "TTLL12", "TTLL4", "TTYH3", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUBGCP3", "TUFM", "TWF1", "TWNK", "TXLNA", "TXLNG", "TXNDC12", "TXNDC17", "TXNDC5", "TXNDC9", "TXNL1", "TXNL4A", "TXNRD1", "TXNRD2", "TYMS", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBFD1", "UBL5", "UBLCP1", "UBQLN4", "UBR1", "UBR4", "UBR5", "UBTF", "UBXN4", "UCHL5", "UFD1", "UFL1", "UFM1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC119", "UNC119B", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCR10", "UQCRB", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "URB2", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP33", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VAT1", "VBP1", "VCL", "VCP", "VDAC1", "VDAC2", "VDAC3", "VIM", "VIRMA", "VMP1", "VPS16", "VPS25", "VPS26A", "VPS29", "VPS33A", "VPS33B", "VPS35", "VPS4A", "VPS4B", "VPS50", "VRK1", "VRK3", "VTA1", "VWA8", "WAPL", "WARS", "WARS2", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR43", "WDR46", "WDR5", "WDR6", "WDR61", "WDR70", "WDR75", "WDR77", "WDR82", "WFS1", "WIZ", "WNK1", "WTAP", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPO7", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS2", "YIF1A", "YIPF5", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF2", "YTHDF3", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZBTB10", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZCRB1", "ZFR", "ZFYVE16", "ZMPSTE24", "ZMYM4", "ZMYND8", "ZNF207", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF638", "ZNF687", "ZPR1", "ZRANB2", "ZW10", "ZYX"], "leading_proteins": ["AARS2", "ABCB1", "ABHD10", "ACAT2", "ACOX1", "ACOX3", "ACP2", "ACP6", "AGL", "AGPAT1", "AGPS", "AGTRAP", "AHCYL1", "AIFM1", "AKT2", "ALDH3A2", "ANK3", "ANKLE2", "ANXA1", "ANXA11", "APLP2", "APMAP", "APOBEC3C", "APOL2", "APPL1", "ARL2", "ASCC3", "ATP13A1", "ATP5L", "ATP6AP1", "ATP6V0A1", "ATP6V0A2", "ATP6V1C1", "ATP6V1E1", "AUP1", "B4GAT1", "BABAM2", "BICD2", "CARM1", "CASK", "CCDC6", "CDC37", "CEP55", "CERS2", "CHD1", "CHKA", "CLN5", "CLPP", "CNNM3", "CNNM4", "COA3", "COA7", "COMT", "CPD", "CPT2", "CRTAP", "CTBP1", "CTNNBL1", "CTPS1", 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0000000000000000000000000000000000000000..333a1214d8199639769ac4ef25550751a73ab5e1 --- /dev/null +++ b/protein_atlas_subcellular_location_all/consensus.joblib @@ -0,0 +1,3 @@ +version https://git-lfs.github.com/spec/v1 +oid sha256:907265680688ad7abb03348b197f1f14d3f3c539b6c7f46c22bed4a159039f12 +size 61933 diff --git a/protein_atlas_subcellular_location_all/df_merge.tsv b/protein_atlas_subcellular_location_all/df_merge.tsv new file mode 100644 index 0000000000000000000000000000000000000000..c57981107d970e936c6c67aa07afef8fff633223 --- /dev/null +++ b/protein_atlas_subcellular_location_all/df_merge.tsv @@ -0,0 +1 @@ +term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_hit pval_50 pval_100 pval_250 pval_500 diff --git a/protein_atlas_subcellular_location_all/metrics.json b/protein_atlas_subcellular_location_all/metrics.json new file mode 100644 index 0000000000000000000000000000000000000000..eacff5498572c5295a764e7d560e898d164b763c --- /dev/null +++ b/protein_atlas_subcellular_location_all/metrics.json @@ -0,0 +1,7 @@ +{ + "type_of_task": "ranksum", + "signature_size": 2812, + "annotations_size": 33, + "title": "Average number of proteins per term", + "value": 130.66666666666666 +} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/paths.json b/protein_atlas_subcellular_location_all/paths.json new file mode 100644 index 0000000000000000000000000000000000000000..afea74e989476e89fef7f4ccbe85ca61424a6597 --- /dev/null +++ b/protein_atlas_subcellular_location_all/paths.json @@ -0,0 +1 @@ +{"results_path": "results/proteins/hek293t_core/protein_atlas_subcellular_location_all/fragment/C428/C428_val_log2fc"} \ No newline at end of file diff --git a/protein_atlas_subcellular_location_all/result.tsv b/protein_atlas_subcellular_location_all/result.tsv new file mode 100644 index 0000000000000000000000000000000000000000..cd83efc8830b06649297b9f58000f936f0fbe686 --- /dev/null +++ b/protein_atlas_subcellular_location_all/result.tsv @@ -0,0 +1,13 @@ +Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size +Focal adhesion sites 0.5124816392699867 1.802712099414718 0.0714334409836146 0.9133376840109556 0.933489403759154 23 Q15942,O60888,P36404,Q9Y3B8,P11233,Q9Y487,P12814,Q14847,P08183 9 +Intermediate filaments 0.466597356425757 1.542444488168938 0.1229656177688698 0.9868311322565924 0.933489403759154 24 Q9NRW3,O60884,O75832,O75718,Q3SXM5,Q96K76 6 +Vesicles 0.3598635847258071 1.4103387923352195 0.1584396692116116 0.9966285755151564 0.933489403759154 285 O75153,P42785,Q96ES6,Q8NHS3,Q8N4Q0,P30519,P07858,Q8WTV0,Q9Y487,Q9NPR9,Q9UMR5,P10619,P50897,O15118,Q8NCC3,Q8IW92,Q32P28,Q9HD20,P07602,Q06481,Q15437,Q92791,Q8NBX0,P55735,P08236,Q9UFC0,P06865,P13674,P16278,Q9Y287,Q93050,Q9Y4C2,Q96SK2,O60506,Q92783,Q9NUD5,Q96K76,Q9BPZ3,Q7L7X3,P67809,Q9Y679,P31751,O14976,Q96D71,Q92572,P17900,Q15369,Q9HD45,Q96B26,P21964,Q3SXM5,Q9BZF1,Q5BKZ1,Q8IUD2,P10253,O95772,P11717,Q07954,Q8TB61,P04066,Q9UKG1,O75312,Q9C0B1,Q01650,Q9Y5X3,Q96CN7,Q6RW13,P61758,Q969M3,Q8IXH7,Q13501,P46926,Q96RQ1,Q5M775,Q5KU26,O94992,P35613,Q14534,Q01085,P42345 80 +Golgi apparatus 0.3604204818078096 1.316273809586837 0.1880821580730649 0.998967479198365 0.933489403759154 145 Q86SF2,Q8NEW0,Q9HD45,Q8TD16,O00231,O15212,O43493,Q6P179,Q8N6H7,Q8N4Q0,P04439,P16278,Q14789,Q9HB40,Q8TEY7,Q02818,Q9Y287,Q93050,Q14247,Q5BKZ1,O15260,Q8IXU6,Q9NPR9,Q6RW13,P80303,Q8NBJ4,P10586,O15344,P50897,Q5VW38,P11717,Q969M3,O00461,P09601,Q99523,O15027,P46926,Q92896,Q96RQ1,A4D1U4,O14976,Q8N3C0,Q5KU26,P40818 44 +Rods & Rings 0.719710689208389 0.9728008762043504 0.3306522771426232 0.9999982359573624 0.933489403759154 4 Q8WTV0 1 +Centriolar satellite 0.3785837865045953 0.7965134965985817 0.4257336339791702 0.9999999887606402 0.933489403759154 23 O15344,Q86UY6,Q8WXW3,Q53EZ4,Q9Y6A5,Q15691,O43169 7 +Mitotic spindle 0.4038396555933204 0.7361418335477311 0.4616443863083224 0.9999999986656029 0.933489403759154 18 P68371,Q96R06,Q9Y6A5,P07437,Q9BVA1,Q9BUF5 6 +Cell Junctions 0.3397111021503176 0.6700303822986755 0.5028384224538698 0.999999999903524 0.933489403759154 40 Q15369,P45985,Q5KU26,Q14126,Q4VCS5,P43490,Q9NV06,Q9Y624,P53985,O43657,Q9Y4C2,Q9BRP8 12 +Microtubules 0.329794511268706 0.6306661032902571 0.5282588669885859 0.9999999999829304 0.933489403759154 46 Q9NWY4,O60830,P55209,P07437,Q13685,Q9BVA1,Q9Y624 7 +Lysosomes 0.3910821494054282 0.5329925874925434 0.5940387114830981 0.9999999999998798 0.933489403759154 13 Q8WTV0 1 +Cytokinetic bridge 0.3439676443167411 0.3874484007444402 0.6984242777542975 1.0 1.0 19 Q9NWY4,Q9BVA1,P07437 3 +Peroxisomes 0.3395327415238383 0.3075120241981482 0.758453672149368 1.0 1.0 14 Q9BY49,Q15067,O15254,O00116 4 diff --git a/protein_atlas_subcellular_location_all/selections.json b/protein_atlas_subcellular_location_all/selections.json new file mode 100644 index 0000000000000000000000000000000000000000..3d07dec8b6babdac6bd4a75d42e1171d361c13b6 --- /dev/null +++ b/protein_atlas_subcellular_location_all/selections.json @@ -0,0 +1 @@ +{"all_annotations": ["Actin filaments", "Cell Junctions", "Centriolar satellite", "Centrosome", "Cytokinetic bridge", "Cytoplasmic bodies", "Cytosol", "Endoplasmic reticulum", "Endosomes", "Focal adhesion sites", "Golgi apparatus", "Intermediate filaments", "Kinetochore", "Lipid droplets", "Lysosomes", "Microtubule ends", "Microtubules", "Midbody", "Midbody ring", "Mitochondria", "Mitotic chromosome", "Mitotic spindle", "Nuclear bodies", "Nuclear membrane", "Nuclear speckles", "Nucleoli", "Nucleoli fibrillar center", "Nucleoli rim", "Nucleoplasm", "Peroxisomes", "Plasma membrane", "Rods & Rings", "Vesicles"], "available_proteins": ["AAAS", "AACS", "AAMP", "AAR2", "AARS", "AARS2", "AARSD1", "AASS", "AATF", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ABHD10", "ABHD14B", "ABRAXAS2", "ACAA2", "ACACA", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACO1", "ACO2", "ACOT13", "ACOT7", "ACOT8", "ACOT9", "ACOX1", "ACOX3", "ACP1", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR10", "ACTR1A", "ACTR2", "ADAR", "ADD1", "ADD3", "ADI1", "ADK", "ADNP", "ADPGK", "ADRM1", "ADSL", "ADSS", "AFDN", "AFG3L2", "AGK", "AGL", "AGPAT1", "AGPS", "AGTRAP", "AHCTF1", "AHCY", "AHCYL1", "AHNAK", "AHSA1", "AIFM1", "AIMP1", "AIMP2", "AIP", "AK1", "AK2", "AK3", "AK6", "AKAP1", "AKAP12", "AKAP8", "AKAP8L", "AKR1A1", "AKR1B1", "AKR7A2", "AKT2", "ALDH18A1", "ALDH1B1", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ALG1", "ALG5", "ALKBH5", "AMOT", "AMPD2", "ANAPC1", "ANAPC16", "ANAPC2", "ANAPC5", "ANAPC7", "ANK3", "ANKFY1", "ANKLE2", "ANKRD17", "ANLN", "ANO6", "ANP32A", "ANP32B", "ANP32E", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1B1", "AP1G1", "AP2A1", "AP2A2", "AP2B1", "AP2M1", "AP3B1", "AP3D1", "AP3S1", "APEH", "APEX1", "API5", "APLP2", "APMAP", "APOBEC3C", "APOOL", "APPL1", "APRT", "AQR", "ARCN1", "ARFGAP1", "ARFGAP2", "ARFIP1", "ARFIP2", "ARG2", "ARHGAP1", "ARHGAP17", "ARHGDIA", "ARID1A", "ARID3B", "ARIH1", "ARIH2", "ARL1", "ARL2", "ARL3", "ARL6", "ARL6IP1", "ARL6IP5", "ARMC6", "ARMCX3", "ARMT1", "ARPC1A", "ARPC2", "ARPC3", "ASCC1", "ASCC3", "ASNA1", "ASNS", "ASPH", "ASPSCR1", "ATAD1", "ATAD2", "ATAD3A", "ATAD3B", "ATAD5", "ATG9A", "ATIC", "ATP13A1", "ATP1B3", "ATP2B1", "ATP5A1", "ATP5B", "ATP5F1", "ATP5H", "ATP5I", "ATP5J2", "ATP5L", "ATP5O", "ATP6V0A1", "ATP6V0A2", "ATP6V1A", "ATP6V1B2", "ATP6V1C1", "ATP6V1D", "ATP6V1E1", "ATP6V1H", "ATPAF1", "ATPIF1", "ATXN10", "ATXN2L", "AUP1", "BABAM2", "BAG6", "BAIAP2", "BANF1", "BASP1", "BAZ1B", "BCAP31", "BCAS2", "BCCIP", "BCL2L13", "BCLAF1", "BCOR", "BDH2", "BICD2", "BIRC6", "BLMH", "BLVRA", "BLVRB", "BMS1", "BNIP1", "BOLA2*", "BOP1", "BPNT1", "BPTF", "BRD1", "BRD2", "BRI3BP", "BRIX1", "BSG", "BTF3", "BUB1B", "BUB3", "BUD31", "BYSL", "BZW1", "BZW2", "C11orf58", "C12orf43", "C19orf70", "C1QBP", "C1orf123", "C1orf35", "C2orf49", "CAB39", "CACYBP", "CAD", "CALD1", "CALR", "CALU", "CAMK2G", "CAND1", "CANX", "CAP1", "CAPN1", "CAPN2", "CAPRIN1", "CAPZA2", "CAPZB", "CARM1", "CARS", "CASK", "CAST", "CBFB", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCAR1", "CCAR2", "CCDC124", "CCDC137", "CCDC22", "CCDC43", "CCDC47", "CCDC58", "CCDC6", "CCDC8", "CCDC86", "CCDC93", "CCNB1", "CCNB2", "CCT2", "CCT3", "CCT4", "CCT6A", "CCT7", "CCT8", "CD2AP", "CD2BP2", "CD47", "CDC123", "CDC27", "CDC37", "CDC42", "CDC5L", "CDC73", "CDCA2", "CDH2", "CDIPT", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK5RAP3", "CDKN2AIP", "CDS2", "CDV3", "CEBPZ", "CELF1", "CENPF", "CENPI", "CEP170", "CEP55", "CERS2", "CFAP20", "CFDP1", "CFL1", "CFL2", "CHAF1A", "CHAF1B", "CHAMP1", "CHCHD3", "CHD1", "CHD1L", "CHD4", "CHD7", "CHEK2", "CHID1", "CHKA", "CHMP2A", "CHMP2B", "CHMP5", "CHMP7", "CHORDC1", "CHTF18", "CHTOP", "CIAPIN1", "CIP2A", "CIRBP", "CISD2", "CKAP2", "CKAP2L", "CKAP5", "CKB", "CLCN3", "CLIC1", "CLIC4", "CLINT1", "CLNS1A", "CLPP", "CLPTM1", "CLPTM1L", "CLPX", "CLTA", "CLTB", "CLTC", "CLUH", "CMAS", "CMPK1", "CMSS1", "CMTR1", "CNDP2", "CNN2", "CNN3", "CNNM3", "CNNM4", "CNOT1", "CNOT7", "CNOT9", "CNP", "CNPY2", "COA3", "COA7", "COG2", "COG7", "COIL", "COLEC12", "COLGALT1", "COMMD4", "COMT", "COPA", "COPB1", "COPB2", "COPG1", "COPS2", "COPS3", "COPS4", "COPS5", "COPS6", "COPS7B", "COPS8", "COTL1", "COX15", "COX4I1", "COX5B", "COX6C", "CPD", "CPNE1", "CPNE3", "CPOX", "CPSF1", "CPSF2", "CPSF7", "CPT2", "CPVL", "CRKL", "CRTAP", "CRYZ", "CS", "CSDE1", "CSE1L", "CSK", "CSNK1A1", "CSTB", "CSTF1", "CSTF3", "CTBP1", "CTBP2", "CTCF", "CTNNA1", "CTNNB1", "CTNNBL1", "CTNND1", "CTPS1", "CTR9", "CTSA", "CTSB", "CTSC", "CTTN", "CUL1", "CUL2", "CUL4B", "CUL5", "CUTA", "CWC15", "CWC22", "CWF19L1", "CXorf57", "CYB5B", "CYB5D2", "CYB5R3", "CYC1", "CYP51A1", "DAD1", "DAP3", "DARS", "DARS2", "DAZAP1", "DBN1", "DBNL", "DBR1", "DBT", "DCAF1", "DCAF13", "DCAF7", "DCAKD", "DCPS", "DCTN1", "DCTN2", "DCTN3", "DCTN4", "DCTPP1", "DCUN1D1", "DCXR", "DDA1", "DDAH2", "DDB1", "DDI2", "DDOST", "DDRGK1", "DDX1", "DDX10", "DDX17", "DDX18", "DDX19A", "DDX20", "DDX21", "DDX23", "DDX24", "DDX28", "DDX39A", "DDX39B", "DDX3X", "DDX41", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX50", "DDX51", "DDX52", "DDX54", "DDX55", "DDX56", "DDX6", "DEK", "DENR", "DERL1", "DERL2", "DFFA", "DHCR7", "DHFR", "DHRS13", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX34", "DHX35", "DHX36", "DHX37", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIABLO", "DIAPH1", "DIAPH3", "DIDO1", "DIMT1", "DIP2B", "DIS3", "DKC1", "DLAT", "DLD", "DLGAP5", "DLST", "DNAAF5", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC11", "DNAJC13", "DNAJC17", "DNAJC2", "DNAJC3", "DNAJC7", "DNAJC8", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DNPH1", "DNTTIP2", "DOCK1", "DOHH", "DPH5", "DPP3", "DPYSL2", "DR1", "DRG1", "DRG2", "DSG2", "DSP", "DTYMK", "DUSP3", "DUT", "DYNC1H1", "DYNC1LI1", "DYNC1LI2", "DYNLL1", "DYNLL2", "DYNLT1", "EARS2", "EBNA1BP2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EDC4", "EDF1", "EDRF1", "EEA1", "EEF1A2", "EEF1B2", "EEF1D", "EEF1E1", "EEF1G", "EEF2", "EEFSEC", "EFL1", "EFTUD2", "EHD1", "EHD4", "EHMT1", "EI24", "EIF2A", "EIF2AK2", "EIF2B1", "EIF2B2", "EIF2B3", "EIF2B4", "EIF2B5", "EIF2S1", "EIF2S2", "EIF3A", "EIF3B", "EIF3D", "EIF3E", "EIF3G", "EIF3H", "EIF3I", "EIF3J", "EIF3K", "EIF3L", "EIF3M", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4B", "EIF4G1", "EIF4G2", "EIF4G3", "EIF4H", "EIF5", "EIF5A", "EIF5B", "ELAC2", "ELAVL1", "ELMOD2", "ELOC", "ELP1", "ELP2", "ELP3", "ELP4", "EMD", "EMG1", "EML4", "ENAH", "ENDOD1", "ENO1", "ENO2", "ENSA", "EP400", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPHX2", "EPPK1", "EPRS", "EPS15", "EPS15L1", "ERAL1", "ERAP1", "ERAP2", "ERC1", "ERCC2", "ERCC3", "ERCC4", "ERCC6L", "ERGIC1", "ERGIC2", "ERH", "ERI1", "ERLIN1", "ERLIN2", "ERP29", "ESD", "ESF1", "ESS2", "ESYT1", "ETFA", "ETFB", "EWSR1", "EXO1", "EXOC6", "EXOC7", "EXOSC1", "EXOSC10", "EXOSC2", "EXOSC3", "EXOSC5", "EXOSC7", "EXOSC8", "EXOSC9", "EZR", "F11R", "FAF1", "FAF2", "FAH", "FAHD1", "FAM114A2", "FAM120A", "FAM162A", "FAM177A1", "FAM208A", "FAM208B", "FAM49B", "FAM8A1", "FAM98A", "FAM98B", "FANCD2", "FANCI", "FAR1", "FARP2", "FARSA", "FARSB", "FASN", "FBL", "FBXO7", "FDFT1", "FDPS", "FDXR", "FEN1", "FERMT2", "FGFR1OP", "FH", "FIP1L1", "FKBP10", "FKBP2", "FKBP3", "FKBP4", "FKBP5", "FKBP8", "FLAD1", "FLII", "FLNA", "FLNB", "FLNC", "FLOT1", "FLOT2", "FMR1", "FN3KRP", "FNDC3A", "FNTA", "FNTB", "FOXRED1", "FRYL", "FSCN1", "FTO", "FTSJ3", "FUBP1", "FUBP3", "FUCA1", "FUS", "FXR1", "FXR2", "FYTTD1", "G3BP1", "G3BP2", "G6PD", "GAA", "GABARAPL2", "GADD45GIP1", "GAK", "GALK1", "GALM", "GALNT2", "GALNT7", "GANAB", "GAPDH", "GAPVD1", "GAR1", "GARS", "GART", "GATAD2A", "GATAD2B", "GATB", "GBF1", "GCAT", "GCC2", "GCDH", "GCFC2", "GCLM", "GCN1", "GDAP1", "GDAP2", "GDI1", "GDI2", "GEMIN4", "GEMIN5", "GET4", "GFM1", "GFPT1", "GGA2", "GHITM", "GIGYF2", "GINS2", "GINS3", "GINS4", "GLB1", "GLB1L2", "GLDC", "GLG1", "GLMN", "GLO1", "GLOD4", "GLRX", "GLRX5", "GLS", "GLUD1", "GLYR1", "GM2A", "GMFB", "GMPPA", "GMPS", "GNA13", "GNAI2", "GNAI3", "GNL1", "GNL2", "GNL3", "GNL3L", "GNPDA1", "GOLGB1", "GOLIM4", "GOLM1", "GORASP2", "GOT1", "GPAA1", "GPD2", "GPHN", "GPI", "GPR107", "GPR108", "GPS1", "GPX8", "GRB2", "GRHPR", "GRPEL1", "GRSF1", "GRWD1", "GSDME", "GSPT1", "GSR", "GSS", "GSTK1", "GSTM2", "GSTM3", "GTF2F1", "GTF2I", "GTF3C1", "GTF3C2", "GTF3C3", "GTF3C4", "GTF3C5", "GTPBP1", "GTPBP3", "GTPBP4", "GUSB", "GYG1", "GYS1", "H1F0", "H1FX", "H2AFX", "H2AFY", "H2AFY2", "H4C1*", "HACD3", "HACL1", "HADH", "HADHA", "HADHB", "HAT1", "HBS1L", "HCFC1", "HDAC1", "HDAC2", "HDGF", "HDGFL2", "HDHD2", "HDHD5", "HDLBP", "HEATR1", "HEATR3", "HEATR6", "HEBP1", "HECTD1", "HELLS", "HELZ", "HEXA", "HEXIM1", "HGS", "HIBCH", "HINT2", "HIRIP3", "HIST1H1C", "HIST1H1E", "HK1", "HK2", "HLA-A", "HLCS", "HLTF", "HM13", "HMBS", "HMCES", "HMGA1", "HMGA2", "HMGB1", "HMGB2", "HMGB3", "HMGCS1", "HMGN2", "HMOX1", "HMOX2", "HNRNPA0", "HNRNPA1", "HNRNPA2B1", "HNRNPA3", "HNRNPAB", "HNRNPC", "HNRNPD", "HNRNPDL", "HNRNPF", "HNRNPH1", "HNRNPH2", "HNRNPH3", "HNRNPK", "HNRNPL", "HNRNPM", "HNRNPR", "HNRNPU", "HNRNPUL1", "HNRNPUL2", "HP1BP3", "HPF1", "HPRT1", "HS2ST1", "HSD17B11", "HSD17B4", "HSDL1", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA12A", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPB1", "HSPB11", "HSPBP1", "HSPD1", "HSPH1", "HTATSF1", "HTT", "HUWE1", "IARS", "IARS2", "IBA57", "ICE1", "IDH1", "IDH2", "IDH3A", "IDH3B", "IFIT5", "IFNGR1", "IGBP1", "IGF2BP1", "IGF2BP2", "IGF2BP3", "IGF2R", "IK", "IKBIP", "ILF2", "ILF3", "ILKAP", "ILVBL", "IMMT", "IMP3", "IMP4", "IMPAD1", "IMPDH2", "INCENP", "INTS1", "INTS13", "INTS14", "INTS3", "IPO11", "IPO4", "IPO5", "IPO7", "IPO8", "IPO9", "IQGAP1", "IQGAP2", "IQSEC1", "IRF2BPL", "ISOC1", "IST1", "ISYNA1", "ITCH", "ITGB1", "ITM2B", "ITPA", "ITPK1", "IVD", "IWS1", "JAGN1", "JMJD6", "JPT2", "JUP", "KARS", "KAT7", "KCTD12", "KDELC2", "KDM1A", "KDM1B", "KDM2A", "KDM3B", "KDM5A", "KHDRBS1", "KHDRBS3", "KHSRP", "KIAA0100", "KIAA0319L", "KIAA0368", "KIAA1147", "KIAA2013", "KIF11", "KIF14", "KIF18A", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "KIN", "KLC1", "KMT2A", "KNTC1", "KPNA1", "KPNA2", "KPNA3", "KPNA4", "KPNA6", "KPNB1", "KRI1", "KRR1", "KTN1", "KYAT3", "LAMTOR1", "LANCL1", "LAP3", "LARP1", "LARP4", "LARP4B", "LARP7", "LARS", "LARS2", "LAS1L", "LASP1", "LBR", "LCLAT1", "LDHA", "LDHB", "LEMD2", "LEMD3", "LENG8", "LETM1", "LGALS3", "LIG3", "LIMA1", "LIN28B", "LMAN1", "LMNA", "LMNB1", "LMNB2", "LONP1", "LPCAT1", "LRBA", "LRP1", "LRPAP1", "LRPPRC", "LRRC40", "LRRC41", "LRRC47", "LRRC59", "LRSAM1", "LRWD1", "LSM12", "LSM14A", "LSM2", "LSM4", "LSM6", "LSM7", "LSM8", "LTA4H", "LTV1", "LUC7L2", "LUC7L3", "LYAR", "LYPLA1", "LZTFL1", "MACF1", "MAD2L1", "MAGED2", "MAK16", "MANBA", "MANF", "MAP1B", "MAP2K1", "MAP2K4", "MAP4", "MAPK1", "MAPK14", "MAPRE1", "MAPRE2", "MARC1", "MARCKS", "MARCKSL1", "MARS", "MAT2A", "MAT2B", "MATR3", "MAU2", "MBD3", "MBOAT7", "MCCC1", "MCCC2", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "MCMBP", "MDC1", "MDH1", "MDH2", "MDN1", "ME2", "MECP2", "MED4", "METTL13", "METTL16", "MFAP1", "MFF", "MFN1", "MFN2", "MFSD10", "MFSD14B", "MFSD3", "MFSD8", "MGEA5", "MGME1", "MGST3", "MIA2", "MIA3", "MICU1", "MICU2", "MID1", "MIF", "MINDY3", "MIPEP", "MKI67", "MKRN2", "MMS19", "MOGS", "MORC2", "MORF4L1", "MORF4L2", "MOV10", "MPDU1", "MPG", "MPHOSPH10", "MPHOSPH8", "MPI", "MPP2", "MPP7", "MPRIP", "MPST", "MRE11", "MRPL1", "MRPL10", "MRPL11", "MRPL12", "MRPL14", "MRPL15", "MRPL19", "MRPL2", "MRPL20", "MRPL21", "MRPL28", "MRPL37", "MRPL38", "MRPL39", "MRPL40", "MRPL41", "MRPL43", "MRPL44", "MRPL47", "MRPL51", "MRPL53", "MRPL9", "MRPS11", "MRPS15", "MRPS2", "MRPS22", "MRPS23", "MRPS25", "MRPS27", "MRPS28", "MRPS31", "MRPS34", "MRPS35", "MRPS5", "MRPS7", "MRPS9", "MRTO4", "MSH2", "MSH3", "MSH6", "MSI2", "MSMO1", "MSN", "MSTO1", "MTA1", "MTA2", "MTAP", "MTBP", "MTCH2", "MTDH", "MTHFD1L", "MTHFD2", "MTHFS", "MTIF2", "MTOR", "MTPAP", "MTPN", "MTR", "MTX1", "MTX2", "MTX3", "MUT", "MXRA7", "MYADM", "MYBBP1A", "MYCBP", "MYCBP2", "MYG1", "MYH10", "MYH9", "MYO1B", "MYO1C", "MYO1D", "MYO6", "NAA15", "NAA25", "NAA35", "NAA40", "NAA50", "NAE1", "NAMPT", "NANS", "NAP1L1", "NAP1L4", "NAPA", "NARS", "NASP", "NAT10", "NAXE", "NBAS", "NCAPD2", "NCAPD3", "NCAPH", "NCBP1", "NCBP3", "NCDN", "NCKAP1", "NCL", "NCLN", "NCOA5", "NCSTN", "NDC1", "NDUFA10", "NDUFA13", "NDUFA4", "NDUFA7", "NDUFA9", "NDUFAF1", "NDUFAF2", "NDUFAF4", "NDUFB4", "NDUFB5", "NDUFB9", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFV2", "NECAP2", "NEFM", "NELFCD", "NELFE", "NF1", "NFATC2IP", "NHLRC2", "NIFK", "NIP7", "NIPBL", "NIPSNAP2", "NIT2", "NKRF", "NKTR", "NLE1", "NLN", "NME1", "NMT1", "NNT", "NOB1", "NOC2L", "NOC3L", "NOC4L", "NOL10", "NOL11", "NOL6", "NOL7", "NOL8", "NOL9", "NOLC1", "NOM1", "NONO", "NOP14", "NOP16", "NOP2", "NOP56", "NOP58", "NOP9", "NOSIP", "NOVA2", "NPC1", "NPEPPS", "NPLOC4", "NPM1", "NRDC", "NSA2", "NSD2", "NSDHL", "NSF", "NSFL1C", "NSMCE2", "NSUN2", "NSUN5", "NT5DC1", "NTMT1", "NTPCR", "NUB1", "NUCB1", "NUCB2", "NUDC", "NUDCD1", "NUDT1", "NUDT21", "NUDT5", "NUDT9", "NUF2", "NUFIP2", "NUMA1", "NUP107", "NUP133", "NUP153", "NUP155", "NUP188", "NUP37", "NUP43", "NUP50", "NUP54", "NUP62", "NUP85", "NUP88", "NUPL2", "NVL", "NXF1", "NXN", "OAT", "OCIAD1", "OCRL", "OGDH", "OGT", "OLA1", "OPA1", "ORC2", "ORC3", "ORC5", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "OTUB1", "OXA1L", "OXCT1", "P3H1", "P3H4", "P4HA1", "P4HB", "PA2G4", "PABPC1", "PABPC4", "PABPN1", "PACSIN2", "PACSIN3", "PAF1", "PAFAH1B1", "PAFAH1B3", "PAICS", "PAIP1", "PAIP2", "PAK1IP1", "PAK2", "PALLD", "PANK4", "PAPOLA", "PAPSS1", "PAPSS2", "PARK7", "PARN", "PARP1", "PAWR", "PBDC1", "PBK", "PBRM1", "PC", "PCBD1", "PCBP1", "PCBP2", "PCCA", "PCID2", "PCK2", "PCLAF", "PCM1", "PCMT1", "PCNA", "PCNP", "PDAP1", "PDCD11", "PDCD4", "PDCD5", "PDCD6", "PDCD6IP", "PDCL3", "PDHA1", "PDHB", "PDIA3", "PDIA4", "PDIA6", "PDK3", "PDLIM1", "PDLIM5", "PDPR", "PDS5A", "PDS5B", "PDXDC1", "PEBP1", "PECR", "PEF1", "PELP1", "PEPD", "PES1", "PEX14", "PEX19", "PFAS", "PFDN2", "PFDN5", "PFDN6", "PFKL", "PFKM", "PFKP", "PFN1", "PGAM1", "PGAM5", "PGD", "PGLS", "PGM1", "PGM2", "PGM2L1", "PGM3", "PGP", "PGRMC1", "PGRMC2", "PHAX", "PHB", "PHB2", "PHC2", "PHF3", "PHF5A", "PHF6", "PHGDH", "PHIP", "PI4K2A", "PI4KA", "PIBF1", "PICALM", "PIK3C2A", "PIK3R4", "PIN4", "PIR", "PITPNB", "PITRM1", "PKM", "PKN2", "PLA2G15", "PLAA", "PLCG1", "PLD3", "PLEC", "PLIN3", "PLOD1", "PLOD2", "PLRG1", "PLS3", "PMPCA", "PMPCB", "PNN", "PNO1", "PNP", "PNPT1", "PODXL", "POGZ", "POLA1", "POLD1", "POLD2", "POLDIP2", "POLDIP3", "POLE", "POLE3", "POLE4", "POLR1A", "POLR1B", "POLR1C", "POLR1E", "POLR2B", "POLR2C", "POLR2D", "POLR2E", "POLR2G", "POLR2H", "POLR3A", "POLR3B", "POLR3C", "POLRMT", "POP1", "POP7", "POR", "PPA1", "PPA2", "PPAT", "PPIB", "PPID", "PPIF", "PPIL1", "PPIL4", "PPM1F", "PPM1G", "PPOX", "PPP1CA", "PPP1CB", "PPP1R10", "PPP1R12A", "PPP1R7", "PPP1R8", "PPP2R1A", "PPP2R1B", "PPP2R2A", "PPP2R5D", "PPP3CA", "PPP4R3A", "PPP5C", "PPP6R3", "PPT1", "PPT2", "PRC1", "PRCC", "PRCP", "PRDX3", "PRDX4", "PRDX5", "PRDX6", "PREB", "PREP", "PRIM2", "PRKAA1", "PRKACA", "PRKAG1", "PRKAR1A", "PRKCB", "PRKCSH", "PRKDC", "PRMT1", "PRMT5", "PRPF19", "PRPF3", "PRPF31", "PRPF38A", "PRPF4", "PRPF40A", "PRPF4B", "PRPF6", "PRPF8", "PRPSAP1", "PRPSAP2", "PRRC1", "PRRC2A", "PRRC2C", "PRSS3", "PRTFDC1", "PSAP", "PSAT1", "PSIP1", "PSMA1", "PSMA4", "PSMA5", "PSMA6", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD1", "PSMD10", "PSMD11", "PSMD12", "PSMD13", "PSMD14", "PSMD3", "PSMD7", "PSMD8", "PSME1", "PSME2", "PSME3", "PSME4", "PSMG1", "PSPC1", "PTBP1", "PTCD1", "PTCD3", "PTGES2", "PTGES3", "PTGR2", "PTPA", "PTPN1", "PTPN11", "PTPRF", "PTRH2", "PUDP", "PUF60", "PUM1", "PUM3", "PUS7", "PWP1", "PWP2", "PWWP2A", "PYCR2", "PYGB", "PYGL", "PYM1", "QARS", "QKI", "QPRT", "QSOX2", "RAB13", "RAB14", "RAB1A", "RAB23", "RAB3B", "RAB3GAP1", "RAB3GAP2", "RAB5A", "RAB5B", "RAB5C", "RAB7A", "RAB8A", "RAB9A", "RABGAP1", "RAC1", "RACGAP1", "RACK1", "RAD21", "RAD23B", "RAD50", "RAE1", "RAI14", "RALA", "RALY", "RAN", "RANBP1", "RANBP2", "RANBP3", "RANBP9", "RANGAP1", "RAP1GDS1", "RAPGEF2", "RARS", "RAVER1", "RBBP5", "RBBP6", "RBM10", "RBM12", "RBM12B", "RBM14", "RBM15", "RBM17", "RBM19", "RBM22", "RBM25", "RBM26", "RBM28", "RBM3", "RBM34", "RBM39", "RBM4", "RBM42", "RBM45", "RBM5", "RBM8A", "RBMX", "RBMXL1", "RBPJ", "RCC1", "RCL1", "RCN1", "RCN2", "RCOR1", "RDH13", "RDX", "RECQL", "REEP5", "REPS1", "RER1", "RETREG3", "REXO2", "REXO4", "RFC1", "RFC2", "RFC3", "RFC4", "RFC5", "RHOT2", "RIC8A", "RIF1", "RIPK1", "RMDN1", "RNASEH2A", "RNASEH2B", "RNF14", "RNF2", "RNF20", "RNF219", "RNF40", "RNH1", "RNMT", "RNPEP", "RNPS1", "RPA1", "RPA2", "RPAP3", "RPF1", "RPF2", "RPL10", "RPL10A", "RPL12", "RPL13", "RPL13A", "RPL14", "RPL17", "RPL18", "RPL18A", "RPL19", "RPL21", "RPL22", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL28", "RPL29", "RPL3", "RPL30", "RPL32", "RPL34", "RPL35", "RPL36", "RPL36A", "RPL37A", "RPL38", "RPL4", "RPL5", "RPL6", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPLP0", "RPLP2", "RPN1", "RPN2", "RPP30", "RPRD1A", "RPRD1B", "RPRD2", "RPS10", "RPS11", "RPS12", "RPS13", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS23", "RPS24", "RPS25", "RPS26", "RPS28", "RPS3", "RPS3A", "RPS5", "RPS6", "RPS6KA1", "RPS6KA3", "RPS7", "RPS8", "RPSA", "RRBP1", "RREB1", "RRM1", "RRM2", "RRP1", "RRP12", "RRP15", "RRP1B", "RRP8", "RRP9", "RRS1", "RSF1", "RSL1D1", "RSL24D1", "RSU1", "RTCB", "RTFDC1", "RTN3", "RTN4", "RTRAF", "RUVBL1", "RUVBL2", "S100A11", "SACM1L", "SAE1", "SAFB", "SAFB2", "SALL2", "SAMD4B", "SAMHD1", "SAMM50", "SAP18", "SAP30BP", "SAR1A", "SARNP", "SARS", "SARS2", "SART1", "SART3", "SBDS", "SBNO1", "SCAF1", "SCAF11", "SCAF4", "SCAMP2", "SCAMP3", "SCAMP4", "SCARB1", "SCARB2", "SCCPDH", "SCD", "SCML2", "SCO2", "SCP2", "SCPEP1", "SCRIB", "SCRN1", "SDAD1", "SDE2", "SDHA", "SDHB", "SDR39U1", "SEC11A", "SEC13", "SEC14L2", "SEC16A", "SEC23A", "SEC23B", "SEC23IP", "SEC24A", "SEC24C", "SEC31A", "SEC61A1", "SEC61B", "SEC63", "SELENBP1", "SENP3", "SEPHS1", "SEPT11", "SEPT2", "SEPT7", "SEPT9", "SERBP1", "SERPINB6", "SERPINH1", "SET", "SETD2", "SETDB1", "SF1", "SF3A1", "SF3A2", "SF3A3", "SF3B1", "SF3B2", "SF3B3", "SF3B4", "SF3B6", "SFPQ", "SFSWAP", "SFXN1", "SFXN2", "SFXN4", "SGPL1", "SGTA", "SH3BGRL", "SH3GL1", "SH3GLB1", "SH3GLB2", "SHMT2", "SHTN1", "SIN3A", "SIRT1", "SIRT2", "SKIV2L", "SKIV2L2", "SKP1", "SKP2", "SLC12A2", "SLC16A1", "SLC1A5", "SLC25A10", "SLC25A12", "SLC25A13", "SLC25A17", "SLC25A19", "SLC25A20", "SLC25A24", "SLC25A26", "SLC25A3", "SLC25A32", "SLC25A4", "SLC25A5", "SLC25A6", "SLC27A4", "SLC2A1", "SLC30A7", "SLC35B2", "SLC35F2", "SLC3A2", "SLC7A5", "SLC9A3R1", "SLC9A6", "SLFN11", "SLIRP", "SLK", "SLTM", "SMAP1", "SMARCA1", "SMARCA4", "SMARCA5", "SMARCAD1", "SMARCB1", "SMARCC1", "SMARCC2", "SMARCD1", "SMARCE1", "SMC1A", "SMC2", "SMC3", "SMC4", "SMC5", "SMC6", "SMCHD1", "SMN1*", "SMNDC1", "SMPD4", "SMU1", "SMYD3", "SNAP23", "SNAP29", "SNAPIN", "SND1", "SNRNP200", "SNRNP40", "SNRNP70", "SNRPA", "SNRPA1", "SNRPB2", "SNRPC", "SNRPD2", "SNRPD3", "SNW1", "SNX1", "SNX2", "SNX27", "SNX5", "SNX6", "SNX9", "SOD2", "SON", "SORD", "SORT1", "SPAG5", "SPAG9", "SPART", "SPC24", "SPC25", "SPCS2", "SPECC1", "SPECC1L", "SPEN", "SPR", "SPTAN1", "SPTBN1", "SPTLC1", "SQLE", "SQSTM1", "SRCAP", "SREK1", "SRFBP1", "SRI", "SRM", "SRP14", "SRP54", "SRP68", "SRPK1", "SRPRB", "SRRM1", "SRRM2", "SRRT", "SRSF1", "SRSF10", "SRSF11", "SRSF3", "SRSF4", "SRSF5", "SRSF6", "SRSF7", "SRSF9", "SSB", "SSBP1", "SSR1", "SSRP1", "STAG1", "STAG2", "STAM", "STARD3", "STARD3NL", "STARD7", "STAT1", "STAT3", "STAU1", "STIP1", "STMN1", "STOML2", "STRAP", "STT3B", "STUB1", "STX12", "STX18", "STX4", "STX5", "STX7", "STX8", "STXBP3", "SUB1", "SUCLA2", "SUCLG1", "SUCLG2", "SUGP1", "SUGP2", "SUGT1", "SUN1", "SUN2", "SUPT16H", "SUPT5H", "SUPT6H", "SUPV3L1", "SURF4", "SURF6", "SUZ12", "SV2A", "SWAP70", "SYAP1", "SYMPK", "SYNCRIP", "SYNE2", "SYNGR2", "TAB1", "TACC3", "TAF15", "TAF5", "TAF6L", "TAGLN2", "TALDO1", "TAMM41", "TAOK1", "TARDBP", "TARS", "TARS2", "TBC1D15", "TBC1D4", "TBC1D8B", "TBC1D9B", "TBCA", "TBCB", "TBK1", "TBL2", "TBL3", "TBRG4", "TCAF1", "TCEA1", "TCERG1", "TCF20", "TCOF1", "TECR", "TELO2", "TERF2IP", "TES", "TEX10", "TFAM", "TFG", "TFIP11", "TFRC", "TGOLN2", "THEM6", "THOC1", "THOC2", "THOC3", "THOC5", "THOC6", "THOP1", "THRAP3", "THUMPD1", "TIA1", "TIAL1", "TIGAR", "TIMM17A", "TIMM17B", "TIMM23", "TIMM44", "TIMM50", "TJP1", "TKT", "TLN1", "TM9SF3", "TMA16", "TMCO1", "TMED10", "TMED2", "TMEM109", "TMEM115", "TMEM126A", "TMEM167A", "TMEM192", "TMEM201", "TMEM205", "TMEM209", "TMEM214", "TMEM230", "TMEM259", "TMEM97", "TMOD3", "TMPPE", "TMX1", "TMX2", "TMX4", "TNPO1", "TNPO3", "TOMM20", "TOMM22", "TOMM34", "TOMM40", "TOMM5", "TOMM70", "TOP1", "TOP2A", "TOP2B", "TOPBP1", "TOR1AIP1", "TOX4", "TP53", "TP53BP1", "TP53BP2", "TPD52", "TPD52L2", "TPI1", "TPM1", "TPM3", "TPM4", "TPP2", "TPR", "TPRKB", "TPT1", "TPX2", "TRA2A", "TRA2B", "TRABD", "TRAP1", "TRAPPC11", "TRAPPC4", "TRAPPC5", "TRAPPC8", "TRIM21", "TRIM24", "TRIM25", "TRIM26", "TRIM28", "TRIM33", "TRIP12", "TRIP13", "TRIP4", "TRMT10C", "TRMT11", "TRMT112", "TRMT1L", "TRMT2A", "TRMT6", "TRMU", "TROVE2", "TRRAP", "TRUB1", "TSFM", "TSG101", "TSNAX", "TSPAN6", "TSPYL1", "TSR1", "TSR3", "TST", "TSTA3", "TTC1", "TTC19", "TTC21B", "TTC27", "TTC37", "TTC38", "TTC4", "TTLL12", "TTLL4", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUBGCP2", "TUFM", "TWF1", "TXLNA", "TXLNG", "TXNDC5", "TXNDC9", "TXNL1", "TXNL4A", "TXNRD1", "TXNRD2", "U2AF2", "U2SURP", "UAP1", "UBA1", "UBA2", "UBA3", "UBA6", "UBAP2L", "UBE2K", "UBE2L3", "UBE2M", "UBE2O", "UBE2S", "UBE3A", "UBE3C", "UBE4A", "UBFD1", "UBLCP1", "UBQLN4", "UBR1", "UBR4", "UBR5", "UBTF", "UBXN4", "UCHL5", "UFD1", "UFL1", "UGDH", "UGGT1", "UGP2", "UHRF1", "UMPS", "UNC45A", "UNG", "UPF1", "UPF2", "UPF3B", "UQCRC1", "UQCRC2", "UQCRFS1", "UQCRQ", "URB1", "URB2", "USMG5", "USO1", "USP10", "USP11", "USP14", "USP24", "USP28", "USP33", "USP36", "USP39", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP11", "UTP14A", "UTP15", "UTP18", "UTP20", "UTP3", "UTP4", "UTP6", "UTRN", "VAMP7", "VAPA", "VAPB", "VARS1", "VBP1", "VCL", "VCP", "VDAC2", "VDAC3", "VIM", "VIRMA", "VMP1", "VPS25", "VPS26A", "VPS29", "VPS33A", "VPS35", "VPS4A", "VPS4B", "VPS50", "VRK1", "VRK3", "VTA1", "VWA8", "WAPL", "WARS", "WARS2", "WBP11", "WBP2", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR33", "WDR36", "WDR46", "WDR5", "WDR6", "WDR61", "WDR70", "WDR77", "WDR82", "WIZ", "WNK1", "WTAP", "XAB2", "XPNPEP1", "XPNPEP3", "XPO1", "XPO4", "XPO5", "XPOT", "XRCC1", "XRCC5", "XRCC6", "XRN1", "XRN2", "YARS", "YARS2", "YBX1", "YBX3", "YEATS2", "YIF1A", "YIPF5", "YKT6", "YLPM1", "YME1L1", "YRDC", "YTHDC1", "YTHDC2", "YTHDF2", "YWHAB", "YWHAE", "YWHAG", "YWHAQ", "ZADH2", "ZBTB10", "ZC3H11A", "ZC3H14", "ZC3H15", "ZC3H18", "ZC3H7A", "ZC3HAV1", "ZC3HC1", "ZCCHC3", "ZFR", "ZFYVE16", "ZMYM4", "ZMYND8", "ZNF207", "ZNF318", "ZNF326", "ZNF512", "ZNF512B", "ZNF638", "ZNF687", "ZPR1", "ZRANB2", "ZW10", "ZYX"], "leading_proteins": ["AAMP", "ABCB1", "ACOX1", "ACOX3", "ACTN1", "AGPS", "AGTRAP", "AKT2", "AMOT", "AP3S1", "APLP2", "APOBEC3C", "APPL1", "ARFGAP2", "ARL2", "ASCC3", "ATP13A1", "ATP6V0A1", "ATP6V0A2", "AUP1", "BICD2", "BSG", "CEP55", "CLUH", "COLEC12", "COMT", "CRTAP", "CTSA", "CTSB", "CTTN", "CUTA", "CYB5B", "DCAF13", "DNAJA2", "DSG2", "ELOC", "ERAP2", "ERC1", "ERGIC2", "EXOSC8", "F11R", "FTO", "FUCA1", "GAA", "GAK", "GALNT7", "GLB1", "GLB1L2", "GLG1", "GM2A", "GNPDA1", "GOLGB1", "GOLIM4", "GOLM1", "GPR107", "GPR108", "GUSB", "HEXA", "HEXIM1", "HLA-A", "HMOX1", "HMOX2", "HPF1", "HSDL1", "IGF2R", "ISOC1", "ITM2B", "KIAA1147", "LASP1", "LRP1", "LRWD1", "MAP2K4", "MAPRE1", "MFSD3", "MFSD8", "MID1", "MTOR", "NAA40", "NAMPT", "NAP1L1", "NELFCD", "NPC1", "NUCB1", "NUCB2", "OSBPL8", "P3H1", "P3H4", "P4HA1", "PAIP2", "PECR", "PFDN6", "PIBF1", "PLA2G15", "PPT1", "PPT2", "PRCP", "PSAP", "PSMD10", "PSMD11", "PTPRF", "PYM1", "RALA", "REPS1", "REXO2", "SCARB1", "SCCPDH", "SCPEP1", "SEC13", "SEC16A", "SEC23B", "SLC16A1", "SLC30A7", "SLC35B2", "SLC35F2", "SLC7A5", "SNX5", "SORT1", "SPAG5", "SPECC1", "SQLE", "SQSTM1", "STAM", "STARD3NL", "SURF4", "SYNCRIP", "TACC3", "TAOK1", "TCAF1", "TGOLN2", "TIAL1", "TIMM17B", "TM9SF3", "TMEM209", "TSPAN6", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "USP33", "USP47", "USP8", "VBP1", "YBX1", "YIPF5", "ZADH2", "ZCCHC3", "ZNF326", "ZPR1", "ZYX"]} \ No newline at end of file