term overlap setsize score pval edge type subtype subtype_key edge_idxs ann_idxs ann_vals sig_size Nuclear outer membrane endoplasmic reticulum membrane network 135 314 7.876099416523562 3.3775952564561378e-15 Q9BQE5,Q6UX53,P57088,P24390,Q8N0U8,Q15392,Q9H0U3,Q8N511,Q99720,Q14849,Q9UGP8,O75844,Q13190,Q9HD20,P43307,P30519,O95864,A1L0T0,Q8TB61,Q9Y6I9,Q8NHH9,P09601,Q14108,O75477,O60725,Q6IAN0,Q9NXE4,Q9UL01,Q8NFQ8,Q99523,O95470,Q6NTF9,Q15800,Q13438,O43731,O15260,Q9BUR5,Q9Y282,O60762,P51648,Q9UBM7,Q8TCJ2,Q8NAT1,Q15629,Q8IV08,O95487,Q14534,Q9H490,Q96G23,Q9Y320,Q9NZ01,Q8TD16,Q9P2W9,O95197,P38435,P07099,O00767,O00264,Q9UM00,Q86XL3,P37268,P67812,Q9NZ08,Q96N66,Q96GC9,O43292,Q16850,Q03519,Q6NUM9,Q03518,Q14739,Q96PC5,P16435,Q9Y5M8,P04439,P35610,Q07065,Q06136,O14678,Q53GQ0,Q86UE4,Q9NP80,Q9UBU6,O00560,P16615,P35613,Q14457,Q2TAA5,Q8TCT9,O15269,Q9P035,Q5BJF2,O15270,P14625,Q9BRR6,Q9Y4P3,P22059,Q96KC8,O43852,P61586,P42345,Q96RL7,Q9NQC3,P48651,Q9NUQ2,Q9BUN8,P04844,P01889,Q96HY6,Q96A33,O60568,O76062,Q9UBV2,P10321,P51571,Q6P179,Q9BU23,O14975,P50402,P46977,Q5T9L3,Q6NUQ1,Q86YN1,Q9BZF1,Q10472,Q70UQ0,Q9Y3B3,O75845,O43865,O76024,Q15904,Q9BT22,P27544,Q8NF37,Q8N5M9 Localization GO Cellular component msigdb_gocc 0,514,511,6,17,23,536,25,26,27,547,32,541,35,36,44,554,54,55,572,568,59,60,566,65,579,591,79,83,600,86,597,88,596,97,98,613,102,605,110,632,628,115,116,120,618,122,640,124,642,641,639,131,132,136,141,644,143,668,161,166,173,185,189,188,194,210,215,216,218,222,224,231,236,244,252,253,258,257,262,263,264,265,266,269,270,287,288,289,286,294,299,295,300,303,313,316,324,321,337,353,358,359,360,367,366,362,369,380,379,376,382,397,393,403,407,421,424,431,430,449,452,453,458,456,462,466,470,469,477,490,494,501,506,515 856,54,906,143,1559,2107,266,644,2796,1773,2816,257,893,1909,424,2215,1218,98,286,295,926,2691,194,97,321,469,837,1161,376,65,605,1356,1186,566,32,470,1507,477,382,2897,871,2178,2070,2222,2947,132,1993,86,1605,618,1144,554,3151,1876,369,244,872,362,1608,3216,141,1508,1954,59,393,300,231,269,1744,1477,316,2859,6,1611,501,3064,725,3192,2641,44,3166,1999,1318,1031,252,270,166,136,2228,353,1395,36,430,2290,753,360,1914,677,2184,910,862,431,403,694,110,1011,966,2953,1712,2670,2387,2081,511,3390,2970,2292,2930,1291,1149,2186,2084,337,1014,2836,3203,2267,3352,1331,1815,173,1164,1296,2703,218,215,1784,2364,258,253,988,875,456,2087,743,3035,541,596,1337,1669,1646,60,1484,2840,287,122,222,27,877,1618,713,1488,2236,809,2560,23,1126,116,1169,88,490,210,288,262,299,790,1375,449,681,1170,2725,579,597,216,452,1234,407,2193,823,514,1039,462,730,263,1621,161,1425,453,120,2161,1128,17,1106,1494,25,1206,515,1426,1457,115,506,83,568,1041,2681,55,1175,628,2565,289,639,1267,1301,1043,2163,1083,2422,1378,1238,379,903,1155,124,188,1499,380,324,189,2759,224,358,2761,792,793,600,1727,26,1085,1086,0,1211,303,1628,2830,494,421,366,613,2961,3403,939,458,2018,1554,3231,536,2206,1730,831,640,3424,2850,665,35,1944,264,703,359,2792,2342,851,367,707,591,641,185,294,2446,1734,2343,131,2249,632,265,397,547,760,79,2944,668,3042,2402,102,642,768,1945,466,2985,313,2815,236,1410,1771,3176,572 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3430 Endoplasmic reticulum 208 488 7.645160472935916 2.0868490451831892e-14 Q9BQE5,P30536,Q6UX53,P57088,P80303,P24390,P52789,P61916,Q8N0U8,Q15392,Q9H0U3,Q8N511,Q99720,Q14849,Q9UGP8,P04062,O75844,Q13190,Q32P28,Q9HD20,P43307,Q12768,P30519,O95864,O43681,A1L0T0,Q8TB61,Q9Y680,Q9Y6I9,Q8NHH9,P09601,Q14108,O75477,O60725,Q6IAN0,Q5VYK3,Q9H6S0,Q9NXE4,Q9UL01,Q9BRK5,Q9H223,Q8NFQ8,Q99523,O95470,Q6NTF9,Q15800,O75718,P46776,Q13438,O43731,O15260,O15173,Q9BUR5,Q92542,Q9Y282,P05023,Q9HD47,O60762,O75503,P51648,Q9UBM7,O15118,Q8TCJ2,Q14BN4,Q8NAT1,Q15629,Q8IV08,O95487,Q14534,Q9H490,Q96G23,Q9Y320,Q9NZ01,Q9P2W9,O95197,Q14257,P38435,P07099,O00767,O00264,Q9UM00,Q9UQB8,Q9HCU5,Q86XL3,Q5VV42,P37268,Q8IZP0,P67812,P00367,P49257,Q92530,Q9NWM8,Q9NUU6,Q9NZ08,Q96N66,O60506,Q96GC9,Q9NPA0,O43292,O43390,P51572,Q969H8,Q9BTY2,P05067,Q15041,Q16850,Q03519,Q6NUM9,Q7Z3C6,Q03518,Q92791,Q14739,P27824,Q96PC5,Q9UBS4,P10619,O60476,P16435,Q6ZXV5,Q9Y5M8,P27635,Q12907,Q96LJ7,Q9UNW1,Q8TBX8,P04439,Q9UHQ9,Q02818,P48449,Q13510,P35610,Q07065,Q9Y394,Q8IUR0,Q06136,O14678,Q53GQ0,Q86UE4,Q9NP80,Q9UBU6,O00560,P62753,P27695,O94832,Q99442,P16615,Q96S66,P35613,Q14457,Q2TAA5,Q8TCT9,Q99797,O15269,Q9P035,Q5BJF2,O15270,P14625,Q9BRR6,Q9Y4P3,P13674,P22059,Q96KC8,O43852,P61586,O95302,P42345,Q96AY3,Q96RL7,Q9NQC3,P48651,Q9NUQ2,Q9BUN8,P04844,P01889,Q96HY6,Q96A33,O60568,O76062,Q13641,Q9UBV2,P10321,O15460,P51571,Q6P179,Q9BU23,O14975,P50402,P46977,O95881,Q5T9L3,P42858,Q6NUQ1,Q86YN1,Q9BZF1,Q10472,Q70UQ0,Q8IY95,Q9Y3B3,O75845,O43865,O00584,O76024,Q15904,Q9BT22,P27544,Q08431,Q8NF37,Q8N5M9 Localization GO Cellular component msigdb_gocc 0,2,514,511,5,6,510,512,17,23,536,25,26,27,547,30,32,541,34,35,36,550,44,554,553,54,55,56,572,568,59,60,566,65,579,71,589,591,79,81,588,83,600,86,597,88,89,595,596,97,98,99,613,612,102,607,106,605,104,110,632,109,628,624,115,116,120,618,122,640,124,642,641,131,132,133,136,141,644,143,668,150,665,161,681,166,682,173,673,677,699,179,707,185,189,187,188,703,194,195,694,716,202,205,713,210,215,216,730,218,219,222,725,224,750,226,227,231,233,236,738,743,240,761,242,244,760,246,753,250,252,253,768,766,258,257,262,263,264,265,266,776,774,771,793,269,792,270,287,288,289,290,286,294,299,295,300,303,313,314,316,324,321,337,333,353,357,358,359,360,367,366,362,369,380,379,376,382,388,397,393,398,403,407,421,424,431,430,436,449,447,452,453,458,456,462,463,466,470,469,467,477,490,494,501,503,506,515 856,54,906,1848,143,1559,2107,266,467,644,2796,1773,2816,257,893,1909,424,1218,109,99,818,98,286,295,3006,398,959,926,2691,194,195,553,97,321,469,837,227,1161,187,376,65,605,2430,2479,1356,1186,566,104,2694,89,32,470,1507,477,382,2069,771,2897,871,2178,2070,2222,2947,132,1993,333,2382,1219,86,1605,618,1144,1703,554,436,3151,673,1876,369,30,244,1877,872,362,607,205,3367,1608,141,1284,1953,1508,1954,59,2147,393,226,3162,1255,2323,314,1536,2384,300,1537,983,231,269,2109,3257,1744,2619,1477,3250,2385,316,2261,2859,3328,2771,6,3325,2262,3063,1611,3048,501,738,774,3064,725,2640,2800,3192,1746,1959,2641,44,965,2,3166,1999,1318,1224,1031,252,270,2413,861,166,136,2228,1709,353,447,36,595,2668,1225,430,2290,753,360,1914,1666,677,2184,910,431,2002,1363,403,694,110,1011,966,3320,510,2953,1712,2670,2387,2510,1749,2081,511,3390,2970,2292,2930,2862,1291,1149,2186,2293,2084,337,1014,2836,512,3203,2043,1887,843,776,2004,1196,3352,1331,3391,1815,173,5,1420,1480,1164,2086,1334,2934,1296,246,1614,2703,218,215,1784,2364,2511,258,1421,253,988,503,875,456,550,2087,2993,743,3035,1716,899,541,1335,596,250,1337,1669,388,1646,60,1484,133,2840,287,122,2114,1202,222,27,1372,624,877,1618,713,1488,1672,2236,1373,2237,809,2560,23,2270,1126,116,990,1452,1169,88,490,210,288,34,262,3245,299,790,1375,449,681,71,1170,2725,579,597,216,452,1234,407,2193,823,514,2610,1039,233,462,730,1723,263,1621,161,1425,453,766,120,2161,1153,1128,463,682,17,1106,1725,1494,25,1206,515,1426,1457,115,1266,1623,2055,2959,506,83,568,1041,2681,55,242,1175,628,2565,289,1831,827,1267,1268,1301,1043,699,612,2163,1083,1524,219,2422,716,1378,1238,379,903,357,1155,3255,2164,124,188,1499,380,324,240,189,2759,224,358,2761,792,2311,793,3387,600,1727,26,1085,290,1086,0,1211,81,303,1628,2830,494,1087,202,421,366,613,2961,3403,939,458,2018,1554,3231,2019,536,2206,588,2812,1730,831,1138,640,3424,589,2850,850,665,35,106,1944,264,703,359,1213,2792,2342,851,2494,367,707,179,2831,591,1556,641,185,294,2446,1734,2343,834,131,2249,632,750,265,397,2814,547,1053,2687,760,79,2944,668,2138,3097,956,3042,2402,761,150,1024,1247,102,2572,1115,642,768,1945,466,1054,2985,1808,2405,313,236,1410,1771,56,3176,572,2068 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3430 Organelle subcompartment 145 380 7.443225913301841 9.82558432878238e-14 Q9BQE5,Q6UX53,P57088,P24390,Q8N0U8,O60512,Q15392,Q9H0U3,Q8N511,Q99720,Q14849,Q9UGP8,P04062,O00461,O75844,Q13190,Q9HD20,P43307,Q16706,P30519,O95864,A1L0T0,Q8TB61,Q9Y6I9,Q8NHH9,P09601,Q14108,O75477,O60725,Q6IAN0,Q5VYK3,O15127,Q9BTU6,Q9NXE4,Q9UL01,Q8NFQ8,Q99523,O95470,Q6NTF9,Q15800,Q13438,O43731,O15260,Q9BUR5,Q9Y282,O60762,Q9NPR9,P51648,Q9UBM7,Q8TCJ2,Q8NAT1,Q15629,Q8IV08,O95487,Q14534,Q9H490,Q96G23,Q9Y320,Q9P2W9,O95197,P38435,P07099,O00264,Q86XL3,P37268,P67812,Q9NZ08,Q96N66,Q96GC9,O43292,P05067,Q16850,Q03519,Q6NUM9,Q03518,Q14739,Q96PC5,P16435,Q9Y5M8,P04439,P35610,Q07065,Q06136,O14678,Q53GQ0,Q86UE4,Q9NP80,Q9UBU6,O00560,Q8TBA6,P16615,P35613,Q14457,Q2TAA5,Q8TCT9,O15269,Q10713,Q9P035,Q5BJF2,O15270,P14625,Q9BRR6,Q9Y4P3,P22059,Q96KC8,O43852,P61586,Q96L58,P42345,Q96RL7,Q9NQC3,P48651,Q9NUQ2,Q9BUN8,P04844,P01889,Q4J6C6,Q96HY6,Q96A33,O60568,O76062,Q9UBV2,P10321,P51571,Q6P179,Q9BU23,O14975,P50402,P46977,Q5T9L3,Q6NUQ1,Q86YN1,Q9BZF1,Q10472,Q70UQ0,Q8NBN3,Q9Y3B3,O75845,O43865,O76024,Q15904,Q9BT22,P27544,Q8NF37,Q8N5M9 Localization GO Cellular component msigdb_gocc 0,514,511,6,17,18,23,536,25,26,27,547,30,31,32,541,35,36,551,44,554,54,55,572,568,59,60,566,65,579,71,72,587,591,79,83,600,86,597,88,596,97,98,613,102,605,107,110,632,628,115,116,120,618,122,640,124,642,131,132,136,141,143,161,166,173,185,189,188,194,205,210,215,216,218,222,224,231,236,244,252,253,258,257,262,263,264,265,266,272,269,270,287,288,289,286,292,294,299,295,300,303,313,316,324,321,337,339,353,358,359,360,367,366,362,369,371,380,379,376,382,397,393,403,407,421,424,431,430,449,452,453,458,456,462,464,466,470,469,477,490,494,501,506,515 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3430 Transporters 159 369 7.109868799769216 1.1615331884216206e-12 P57088,P24390,P61916,O14786,Q9H061,Q9UBX3,P51798,P45880,Q70HW3,Q9C0H2,Q8N511,Q99720,Q14849,Q9H0U3,P00403,Q9Y6M7,Q9UGP8,O75844,Q13190,Q9HD20,P07602,Q7Z3B4,Q99567,Q9Y619,Q9H2V7,Q9H2D1,P28288,O43681,Q8TB61,Q8NHH9,O75477,Q14108,Q9BSK2,Q6NUK1,Q5VW38,P55011,O43808,O15127,P54646,Q9BRK5,Q9C0E2,Q9BXP2,Q99523,Q6NTF9,Q6P4Q7,Q13438,Q9BTX1,Q8N1F7,Q9HAV4,Q9BUR5,O15260,P78310,P05023,P46934,Q8NFH4,O15118,Q8WY22,Q8TCJ2,Q15629,P52294,Q9NR77,Q9Y320,O60637,P11279,O96005,Q9Y6C9,Q9UM00,Q9HCU5,P04083,Q5SRE5,Q9BQT8,P35658,P08183,Q4KMQ2,Q96KP1,P11166,Q8WTV0,P49257,Q9UJS0,Q15070,Q9NPI6,Q96N66,Q9Y287,P21912,Q96GC9,Q15043,O75746,Q9NPA0,P51572,Q02978,O60684,P05067,Q92973,O95067,Q03519,Q7Z3C6,Q00325,P12235,Q03518,Q93050,Q96PC5,Q16543,Q92621,Q6UW68,Q6P4A7,Q6ZXV5,Q07021,P40855,P13473,P57105,P04439,Q92544,Q07065,O14678,Q9UBU6,O00560,Q8TBA6,P16615,P53985,P35613,Q9Y512,Q5BJF2,O15397,Q96L92,Q9NZJ7,P13073,Q16625,Q8IYU8,Q96RL7,Q9BUN8,P04844,O94901,Q96A33,O60313,P20020,Q9UBV2,P30825,O95202,Q96NB2,P12236,O14975,P33176,Q13277,Q9UPT5,Q9UH99,Q8NE01,P46977,Q5T9L3,Q9BZF1,Q8IY95,Q9Y3B3,O43772,O43865,Q8TAA9,Q12769,O76024,Q16891,Q15904,Q9NUT2 Functions Protein Atlas Protein class protein_atlas_protein_class 511,6,512,520,12,13,524,15,16,24,25,26,27,536,28,548,547,32,541,35,38,559,42,45,46,49,555,553,55,568,566,60,61,580,68,574,573,72,75,81,602,601,600,597,598,596,92,611,614,613,98,608,607,103,627,109,114,628,116,117,123,642,126,646,140,145,668,665,148,662,157,657,159,163,686,676,169,677,708,181,704,189,190,693,188,191,692,703,694,696,198,205,208,709,215,730,214,213,218,220,224,229,747,745,232,233,742,739,237,238,244,247,253,257,265,266,272,269,271,270,278,299,328,330,341,336,346,347,358,366,362,368,379,375,385,397,402,401,410,418,424,425,427,435,434,432,430,449,458,463,466,468,469,482,478,477,479,490,519 856,1737,2852,1248,3138,1559,2282,1908,266,1160,1116,2796,257,520,2348,2428,424,2215,109,72,818,98,328,926,3335,553,2501,468,573,469,375,1775,1313,3179,126,1143,198,1009,1355,1473,2408,763,1356,2574,1056,2319,566,979,692,32,1507,802,477,2069,368,2070,2071,2947,709,401,1993,2285,1565,1251,2382,839,1702,140,1443,28,2224,1314,3349,148,244,1877,872,362,607,205,736,1607,963,1608,1221,1952,38,2146,159,1567,1285,3126,3233,840,676,2411,646,1509,213,418,1706,336,237,860,2770,269,1956,385,1147,1119,3191,3343,3127,693,2457,819,6,555,402,1747,2076,425,3167,270,657,2149,2642,1572,2748,2620,2228,739,15,3103,2835,103,430,677,2184,910,1915,862,1058,1192,912,1364,694,524,966,117,1667,1033,1100,986,271,1856,75,1574,574,1418,2387,511,238,1195,3390,1750,2862,2554,1259,1014,2836,512,2416,2932,2804,2645,1815,2153,608,1966,214,1783,2648,696,218,215,742,253,1122,988,1578,2805,2557,478,2087,541,427,596,1337,2936,60,3275,2155,27,1372,1618,191,181,1168,809,116,950,490,229,346,479,1203,163,1675,299,790,1375,662,449,68,2725,3386,597,580,2193,232,598,745,233,16,559,730,756,996,798,463,2909,1681,347,611,25,1426,432,2421,627,568,482,2681,55,272,628,2872,1267,970,169,1833,114,1899,247,747,2422,208,220,1238,379,1405,903,1270,188,1499,686,330,189,410,2424,224,3158,358,792,793,600,42,26,1552,157,81,2830,61,92,366,613,2961,2912,886,601,1941,458,602,2018,24,1554,12,536,49,46,2790,831,2493,1409,942,614,1275,665,35,703,1983,704,123,1764,2445,2792,2400,3429,2569,519,341,2446,1734,2473,265,1215,397,13,2711,547,434,1053,2136,1385,3022,708,3278,2660,2314,2894,855,668,1598,435,1350,190,642,3222,466,3212,2405,2452,278,2214,2281,45,3419,145,548 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3430 Organelle inner membrane 112 242 7.08763072855168 1.364274109903568e-12 Q99623,Q14197,Q69YU5,Q9H061,Q7KZN9,Q9UBX3,Q70HW3,O95168,Q9Y2R0,O60830,O43676,Q16134,Q99720,Q9BQ95,P00403,O75844,P23786,Q9UDX5,Q9Y619,Q9H2V7,O75964,P43304,Q9H2D1,Q9Y5J7,Q13505,O43615,Q9BSK2,P14406,Q6NUK1,P62995,P03886,Q9UDW1,P43243,Q99595,Q6DKK2,Q9NP92,Q9NVH1,Q9BUR5,O96000,Q5XKP0,Q9Y584,Q9Y5L4,Q14728,P36551,P24539,Q9Y6C9,Q13423,Q567V2,Q5SNT2,O14949,Q8IXM6,Q9BQT8,Q9P0J0,Q9H9P8,P53701,Q86Y39,P06576,O75438,Q9H1E5,P82933,Q9UJS0,Q15070,P21912,Q6UXV4,O75746,Q9Y5J9,P82663,Q02978,Q9BYC9,Q96BW9,O14925,Q9NX63,Q00325,P12235,P56385,P09001,Q14739,Q6P4A7,O76031,Q5T9A4,Q96CU9,Q9Y512,Q10713,P08574,Q9Y6M9,Q9NPL8,P13073,Q8IYU8,P14854,O94901,O60313,O76062,P51970,O95202,Q96NB2,O95831,O75306,P12236,Q9H2W6,Q9UH99,P50402,P22830,Q9NVI7,Q9BRJ2,Q9NQ50,Q709F0,O43772,Q9NVS2,Q9UG56,Q16891,Q7Z7H8,Q9NUT2 Localization GO Cellular component msigdb_gocc 517,513,11,12,525,13,16,529,19,20,21,533,26,29,28,32,33,41,45,46,47,556,49,571,58,565,61,64,580,576,73,74,585,78,82,603,616,613,606,626,119,125,638,647,138,145,146,151,661,155,156,157,158,688,167,168,674,671,171,177,708,181,693,697,692,193,695,696,721,717,204,732,214,213,726,723,222,232,251,259,274,278,292,296,326,325,336,347,363,368,375,382,386,401,410,414,413,418,428,434,431,438,443,451,459,457,468,486,487,479,505,519 892,1950,204,155,565,21,2922,468,1142,375,20,763,1441,413,978,1010,671,1532,1442,908,2259,692,32,1029,3081,47,251,382,368,529,3008,401,2033,839,414,606,1443,28,73,1811,736,674,2820,296,723,1878,1392,840,3180,213,418,2769,336,64,363,3331,2770,1316,1744,2639,1119,1446,693,1997,984,438,2771,33,138,2925,3031,1747,784,1478,1781,1257,647,3050,948,1395,585,556,1075,3379,2481,1258,3152,1163,431,2041,386,2669,1100,167,821,2510,2080,726,2267,576,1034,695,1576,1332,2085,930,1333,177,214,696,1227,292,931,1370,1200,146,58,513,1647,638,222,181,533,3131,1673,479,968,951,151,1676,661,811,259,626,11,82,580,1928,232,697,457,16,525,2159,505,168,156,347,1493,1265,3154,1207,2959,1495,1130,920,1236,2012,1132,1978,717,274,2538,3000,1044,972,410,1303,78,517,26,29,157,451,61,1087,2518,613,721,2244,1178,973,1592,3285,1243,12,171,49,46,428,3002,816,1409,942,1660,688,1867,1943,603,325,459,2445,1594,519,2632,616,443,486,2541,2813,732,1159,865,749,158,13,74,41,487,434,708,1530,1350,943,1351,19,2316,1280,1470,2523,2984,1531,2616,1025,278,119,571,193,125,45,145,326 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3430 Mitochondrial envelope 133 320 7.003660090137495 2.493606762786998e-12 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3430 Envelope 184 493 6.719495697957969 1.8235456792846856e-11 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Localization GO Cellular component msigdb_gocc 517,2,513,511,5,510,7,520,9,11,12,13,14,15,16,525,529,19,20,21,533,26,29,28,32,33,543,552,41,42,559,45,46,47,49,556,571,58,59,565,61,64,580,576,73,74,585,78,591,82,83,603,602,600,92,611,616,96,613,99,101,606,627,632,109,114,626,117,621,119,125,642,638,639,654,134,647,138,143,145,146,151,662,661,155,156,157,158,657,688,164,167,168,674,171,671,174,177,708,707,181,705,693,697,692,193,695,696,721,717,204,205,732,216,214,213,726,723,222,749,748,232,238,251,259,263,264,266,274,278,287,292,294,299,296,307,309,310,324,326,325,328,341,336,344,347,349,353,357,358,359,367,363,368,375,382,386,390,396,405,401,410,414,413,418,428,434,431,438,443,451,450,458,459,457,468,467,486,487,478,479,499,505,519 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3430 Transporter activity 96 173 6.587536831757315 4.471830748321565e-11 P30536,P61916,Q9NS69,P21796,P51798,Q7KZN9,Q9UBX3,P45880,Q70HW3,O95168,O60830,O43676,Q9H0U3,Q9C0H2,Q14849,Q9Y6M7,P00403,Q9UGP8,P04062,Q9HD20,Q96ES6,L0R6Q1,Q96SU4,Q99567,Q9Y619,Q9H2V7,O75964,Q9H2D1,P28288,O43681,Q8TB61,Q9BSK2,Q6NUK1,P17900,P55011,O43808,P03886,Q9UDW1,Q99595,Q9BXP2,Q6P4Q7,O15173,P05023,O96000,O15118,Q07820,Q9Y584,Q14728,P38435,P24539,Q13423,Q9UM00,Q9BQT8,Q9P0J0,P08183,Q4KMQ2,P11166,Q8WTV0,P06576,O75438,Q9Y487,Q9UJS0,Q96GC9,Q15043,O75746,Q9Y5J9,O14925,Q03519,Q00325,P12235,Q03518,Q93050,Q6P4A7,O14678,P16615,P53985,Q99797,P51991,P08574,Q9Y277,P22059,Q9Y6M9,P13073,P14854,P20020,P51970,P30825,O95202,Q96NB2,O75306,P12236,O14975,Q8NE01,Q9BZF1,O43772,Q9NUT2 Functions GO Molecular function msigdb_gomf 2,512,7,9,524,525,13,15,16,529,20,21,536,24,27,548,28,547,30,35,37,549,564,42,45,46,47,49,555,553,55,61,580,66,574,573,73,74,78,601,598,99,607,606,109,621,119,638,136,138,146,668,157,158,159,163,676,169,674,671,175,708,188,191,692,193,204,215,214,213,218,220,232,257,269,271,290,297,296,309,316,326,336,363,385,386,402,401,410,413,418,424,432,458,468,519 549,892,2852,1950,2796,257,204,424,109,99,926,21,2922,553,468,573,20,763,1441,413,978,671,1442,692,3081,47,1098,529,3008,401,2033,839,606,1443,28,73,30,607,736,674,1221,1952,2146,159,1567,296,859,840,676,213,418,336,363,269,66,2639,385,1119,3191,3343,9,316,819,138,2925,555,3031,2,402,784,1257,2149,136,2748,15,1075,3379,1914,910,3152,524,386,297,1033,1100,271,574,2080,726,1259,1014,512,214,2464,2648,696,218,215,988,621,146,2973,638,2974,27,191,900,950,3131,1673,163,3386,580,2193,232,598,16,525,730,996,798,1040,432,1130,55,169,882,220,37,188,410,792,564,42,78,290,1552,2887,157,61,2961,1591,601,1553,458,24,536,3380,49,46,1409,942,35,2445,7,519,158,13,74,547,2136,708,668,2689,309,175,119,193,2067,45,3419,548,326 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3430 Intrinsic component of organelle membrane 74 124 5.973041115580074 2.328711795463094e-09 P20020,O76062,P57088,Q8TB36,P10321,O00767,Q8WVX9,Q99442,Q9Y2R0,O60830,Q16134,Q9UM00,Q9HCU5,Q9Y512,Q5SNT2,Q96K12,Q96NB2,Q86XL3,O75844,Q9H9P8,Q8TCT9,Q9P035,Q6ZRP7,L0R6Q1,O14975,Q9UH99,Q15070,Q8TB61,Q9Y4P3,Q13505,Q9Y287,Q6UXV4,Q5T9L3,Q9NPA0,O43292,P51572,Q86YN1,O43808,P42892,O14925,Q99595,Q15041,Q9NX63,Q6NTF9,O95470,Q03519,Q00325,P12235,Q03518,Q9NVH1,P27824,Q14739,Q9BUR5,Q9UG56,O76024,Q9Y282,Q9NQC3,Q6P4A7,Q96A33,Q16891,Q9BUN8,Q9UBM7,P13473,O15118,P57105,O94901,P01889,Q5XKP0,Q15629,P04439,Q8IWA4,O43505,Q9H490,Q9NZ01 Localization GO Cellular component msigdb_gocc 385,382,511,390,393,644,663,793,19,20,533,668,665,278,661,283,410,161,32,688,289,294,552,549,424,434,181,55,313,58,190,697,449,703,194,694,453,573,69,204,78,713,732,597,86,215,214,213,218,616,725,222,613,487,477,102,359,232,379,479,366,632,237,109,238,368,369,626,116,244,756,752,640,641 856,549,644,204,424,109,818,926,194,752,573,1142,20,1010,32,1029,477,382,1098,368,86,839,1443,369,244,393,213,237,385,1610,3064,725,2641,3050,69,1163,1058,1364,694,511,238,1292,1014,214,218,215,875,58,2840,222,1618,713,181,1583,900,116,533,479,951,790,661,449,626,597,232,697,552,1621,161,902,453,756,996,1521,997,1426,2959,1130,390,55,289,663,1083,1378,379,283,410,2761,793,78,2830,1087,366,613,887,2018,1554,3002,640,942,688,665,703,359,2445,616,732,641,294,2446,2343,632,487,3398,434,668,102,190,19,1470,313,1025,278,1771 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3430 Transmembrane transport 85 213 5.9351433053270926 2.935889480170374e-09 Q99623,P52789,Q9NS69,P21796,P51798,Q7KZN9,Q9UBX3,P45880,Q70HW3,O60830,Q9H0U3,Q9C0H2,Q9Y6M7,P00403,Q9UGP8,P04062,O75844,P23786,Q9HD20,Q96ES6,L0R6Q1,Q9Y619,Q9H2V7,O75964,Q9H2D1,P28288,Q8TB61,Q9UHG3,O43615,Q9BSK2,Q6NUK1,P55011,O43808,Q9UDW1,Q99595,Q9BXP2,Q99523,Q6P4Q7,P05023,P46934,Q9HD47,Q14BN4,Q15629,Q07820,Q9Y584,P38435,P24539,Q13423,Q9BQT8,P08183,Q4KMQ2,Q8WTV0,Q96GC9,Q15043,Q06787,O14925,P05067,Q96PU5,Q03519,Q00325,P12235,Q03518,Q6P4A7,O14678,P16615,P53985,Q99797,P08574,Q9Y277,P13073,Q16625,Q8IYU8,P14854,P20020,P30825,O95202,Q96NB2,O95831,P12236,Q8NE01,P42858,Q9BZF1,O43772,O43865,Q9NUT2 Processes and pathways GO Biological process msigdb_gobp 517,510,7,9,524,525,13,15,16,20,536,24,548,28,547,30,32,33,35,37,549,45,46,47,49,555,55,57,565,61,580,574,573,74,78,601,600,598,607,103,106,624,116,621,119,136,138,146,157,159,163,169,188,191,203,204,205,211,215,214,213,218,232,257,269,271,290,296,309,336,346,347,363,385,402,401,410,414,418,432,447,458,468,469,519 549,857,2852,1772,1950,257,204,565,781,468,573,469,2832,20,2408,763,3007,1441,2031,1056,1532,692,32,1507,3081,47,1098,401,839,414,1443,28,30,607,205,736,1607,963,674,1221,1952,3082,2034,2146,159,1567,296,859,2965,840,3180,676,1256,3301,213,418,336,363,269,1444,2109,3303,2504,385,1119,3191,3343,3127,9,819,33,138,2925,774,2640,555,2598,3166,402,784,1318,3167,1257,2149,136,2748,447,15,103,1396,1075,3379,910,2040,1058,2079,1192,524,510,1100,271,1573,1574,574,2080,726,3390,2862,1259,1014,2555,1121,214,2464,2648,696,218,215,2187,2556,203,988,621,3204,1716,146,1228,1669,1670,638,2974,624,713,191,2237,900,116,950,346,1338,968,163,580,2193,232,598,1039,2335,16,525,2275,996,2161,798,347,1863,432,1130,55,2565,169,1236,882,37,188,1499,410,211,793,3387,600,78,517,290,1552,1590,157,61,2961,601,3171,458,24,536,49,46,2370,1409,942,1867,35,106,2445,7,519,1092,13,74,547,2687,57,2136,708,1530,668,309,2345,2404,1025,119,45,3419,548 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3430 Mitochondrion organization 82 200 5.405420166859042 6.465664462886018e-08 Q99623,P30536,P52789,Q9NS69,O14965,P21796,Q69YU5,Q9H061,P45880,O95168,Q9Y2R0,O60830,O43676,P04062,Q16706,Q9UDX5,Q9Y5Z4,Q9Y2S7,Q9Y5J7,Q13505,O43615,Q9BSK2,P14406,P55786,P03886,Q99595,Q6DKK2,Q5JRX3,Q9NVH1,Q96A26,Q9BUR5,P78310,Q8N4H5,O96000,Q5XKP0,Q9Y584,Q9Y5L4,O75153,Q8NAN2,Q9Y6C9,Q9UBN7,Q9P0J0,P07900,Q8N2A8,O14737,Q86Y39,O75438,P49257,Q15070,Q6UXV4,Q9Y5J9,P51572,O14925,Q9NX63,Q7Z3C6,P12235,Q9P032,Q16543,Q9H4A6,P05141,Q5T9A4,Q96CU9,Q9Y512,Q14457,Q99797,Q10713,Q9Y6M9,Q96RL7,O60313,P51970,Q8TB36,O95202,O95831,O75306,Q9NVI7,P42858,Q9NUQ9,Q7L592,Q9UG56,Q16891,Q9NQG6,P27544 Processes and pathways GO Biological process msigdb_gobp 517,2,510,7,521,9,11,12,15,529,19,20,21,30,551,41,50,570,571,58,565,61,64,575,73,78,82,85,616,96,613,608,101,606,626,119,125,127,134,145,666,158,656,164,165,168,671,677,181,697,193,694,204,732,730,213,749,229,748,736,259,274,278,287,290,292,326,358,375,386,390,401,414,413,443,447,475,472,487,479,499,501 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3430 Transporter 74 182 5.262514030810373 1.420988160332582e-07 Q9BQE5,P20020,Q9P2W9,O14678,P24390,P24539,P11279,O00560,Q9UBX3,P16615,Q70HW3,Q9Y6C9,P53985,P30825,O95202,Q9H0U3,Q96NB2,Q9Y6M7,Q9BQT8,Q13190,P08183,P12236,Q12768,Q96ES6,P11166,Q7Z3B4,Q99567,P06576,O14975,Q9Y619,Q9H2V7,Q9Y487,O95249,Q9H2D1,P28288,P49257,Q9UJS0,Q15070,Q9UPT5,Q8TB61,Q9BSK2,Q15043,Q6NUK1,O75746,P17900,P51572,P55011,O43808,O60684,Q9NZJ7,Q92973,Q9Y3B3,Q9C0E2,Q9BXP2,Q99523,Q03519,Q00325,P12235,O43772,Q9HD45,Q03518,Q8N1F7,Q93050,Q92544,O43731,Q12769,Q13277,P05023,Q8NFH4,P13473,P52294,Q9Y584,O95487,Q9NUT2 Drugs and Diseases Pharos Drug Target Ontology pharos_dto 0,385,131,257,6,138,646,266,13,269,16,145,271,402,401,536,410,548,157,541,159,418,550,37,676,559,42,674,424,45,46,175,672,49,555,677,708,181,435,55,61,191,580,692,66,694,574,573,198,341,208,466,602,601,600,215,214,213,468,90,218,611,220,247,97,478,427,607,627,237,117,119,618,519 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3430 Vacuole 76 216 5.236675304489291 1.634949484246903e-07 O14678,P61916,Q9UIQ6,P38435,O00560,Q15165,P51798,P06865,P06280,Q13107,P50897,Q8NCG7,Q9H0U3,Q8N511,Q8TAF3,Q14849,P08236,P04062,Q14457,O14773,P07602,Q5BJF2,Q8WTV0,P33176,P16278,Q13277,Q9H2V7,Q01085,Q9Y487,Q92820,Q9Y5Z4,Q9UM22,O43681,Q8NHP8,Q9Y6I9,P10253,Q9UHG3,P07437,Q14108,Q96GC9,Q15043,P42858,P17900,Q969Q5,P42892,Q9BTY2,Q9BTU6,P15586,P42785,Q9NZJ7,Q99519,Q8IY95,Q9NX40,Q99523,P54802,Q9H7Z7,Q16625,Q8NCC3,Q93050,Q9Y2T2,O00584,Q9NQX7,O15260,P10619,P42345,Q96RL7,O75503,P13473,O15118,P04844,P11117,Q8TBX8,Q8IV08,Q8NF37,Q13510,Q07065 Localization GO Cellular component msigdb_gocc 257,512,137,136,266,139,524,268,275,532,22,534,536,25,152,27,279,30,287,162,38,299,169,425,43,427,46,558,175,433,50,51,553,53,572,311,57,310,60,188,191,447,66,323,69,202,587,206,207,341,340,463,212,600,87,474,346,91,220,617,467,225,98,226,353,358,104,237,109,362,370,242,120,506,250,253 2026,266,467,977,2347,257,162,907,109,98,1071,2216,553,2501,2218,1699,1355,2455,870,2319,104,802,2071,1702,1876,30,895,362,275,268,1952,3082,310,38,1358,656,2146,1567,279,1285,1954,3126,1568,311,226,370,2108,1955,646,237,983,206,43,3257,66,1147,3191,3343,2859,774,3064,2800,3344,3032,2774,425,2149,136,2183,2748,2228,353,207,447,69,2150,2835,775,2928,1363,22,3270,912,2461,1364,524,1011,1855,986,3105,87,2387,2970,2292,1291,2186,2463,1259,512,2932,2804,1643,787,1644,1890,1783,558,2648,3107,1450,3295,2511,253,1578,3204,2557,1716,532,1335,427,250,3015,2234,60,2298,287,27,191,139,2560,346,299,812,2052,730,120,996,463,25,2055,91,534,506,2395,53,152,242,169,2682,1497,612,433,220,323,1624,3075,1155,1270,1461,188,2759,3158,358,3109,340,600,1938,1272,2539,2887,2313,1304,587,202,3422,1066,1941,3172,1136,536,905,1466,46,474,2736,225,2792,1504,212,3021,341,3271,1734,1050,834,1214,57,2136,137,2875,51,1348,1845,956,2740,1696,617,3222,175,1808,2317,2067,891,50,1771,572 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3430 Endoplasmic reticulum 84 204 5.149781833781697 2.607896274187553e-07 O43169,Q8N0U8,Q14849,Q9UGP8,P43307,Q9Y680,Q8NHH9,O75477,O95470,Q15800,P46776,Q13438,O43731,O15260,P51648,Q9UBM7,Q8TCJ2,Q14BN4,Q8IV08,Q96G23,Q9NZ01,Q8WUJ1,Q9P2W9,O95197,Q14257,O96005,O00767,O00264,Q9UM00,Q9HCU5,P46782,Q86XL3,P37268,P49257,Q96GC9,Q15043,O43292,P51572,Q96CN7,Q15041,Q16850,Q03519,Q03518,Q92791,P27824,Q96PC5,Q9UBS4,Q6UW68,P27635,Q9Y3U8,P35610,P62753,Q86UE4,Q99442,P21964,Q8TCT9,O15269,Q9P035,Q5BJF2,P14625,Q96KA5,P13674,Q96KC8,O43852,Q9H3G5,Q9NQC3,P48651,Q9BUN8,P04844,Q96HY6,Q96A33,O76062,P67809,O15460,P51571,P50402,Q5T9L3,Q70UQ0,O75845,Q5HYI8,Q9BT22,P62841,P27544,Q8NF37 Localization Protein Atlas Subcellular protein_atlas_subcellular_location_all 14,17,27,547,36,56,568,566,86,88,595,596,97,98,110,632,628,624,120,124,641,129,131,132,133,140,644,143,668,665,658,161,166,677,188,191,194,694,719,713,210,215,218,219,725,224,750,745,738,762,252,776,263,793,280,289,286,294,299,300,302,314,324,321,331,359,360,366,362,380,379,382,396,398,403,431,449,462,470,491,494,496,501,506 143,644,1909,1218,98,286,398,14,2691,194,97,321,1473,2408,2479,566,470,1507,382,871,2070,132,1993,86,140,1876,872,362,3367,1607,1284,2548,2950,859,1255,2323,314,1536,300,1537,1879,1744,2503,1445,1099,3250,280,3328,2771,2262,501,738,3064,725,2860,2641,965,3067,1031,252,861,166,2228,1540,36,595,2668,1225,1854,658,985,360,1666,677,431,2002,911,403,694,110,3390,2327,2293,2083,1293,1014,2836,3089,1887,3294,2388,843,2605,3106,1365,776,2004,496,1196,2803,1575,1889,2363,1101,1782,3391,396,1420,1480,2086,218,215,2511,1421,2087,899,1335,1482,596,1646,133,2840,2114,1202,27,624,713,191,2236,1373,990,1169,88,210,3337,299,491,449,2725,1234,2273,745,823,462,263,1621,161,1425,120,1128,17,1206,2055,506,568,1041,628,289,1831,129,2163,219,379,903,719,1155,1209,124,188,380,302,324,224,792,793,1085,1086,938,2830,494,366,2018,1554,2019,2206,331,831,665,359,1213,3122,641,294,1734,2343,131,632,750,2210,547,668,762,56,3176 1.9513415899455118,0.6728169776242082,-0.1948058268211105,0.17675834803240076,2.2227671511588163,1.3894476706931538,1.1117439633053623,3.3468758304359083,-0.6729168790091554,1.738437938975464,2.233787760016152,1.2853737321434007,0.02805701137235168,-0.4464943548499513,-0.5021316919187672,0.7752227411673067,0.9462000577616902,0.01126068031324202,1.1523245386286525,0.43080383738421585,-0.26542599868242417,2.0204818903795823,-0.22999085661134913,2.321161071650228,1.9629265380559953,-0.1773059016141884,0.43080383738421585,1.1925938145223307,-1.9474917631058593,-0.03946755021715677,0.14408985151272588,-0.558403728184664,-0.8900812583352817,0.44626893355334946,0.1604504658814682,-0.3914762369552328,1.311585046538852,-0.005591913085313469,1.3506596827179598,-0.005591913085313469,-0.1773059016141884,-0.10791253841717666,-0.5208177336190014,0.04479749007284595,0.25751962221115077,-1.3560056220962575,1.402314093228658,-1.6543045466896755,-0.7311921139115007,-0.35513411913799386,0.8898304908049921,0.5833929390939195,-1.0127520150653435,0.5984052493734849,-0.8099892376198776,-0.6344483133432426,0.3527680424371989,-1.0127520150653435,0.30536674022651894,1.4915153034770001,0.44626893355334946,1.8459424393187207,-0.33706243340680064,-0.005591913085313469,3.0222783212407616,0.7315827923762055,-0.6536448751928122,0.17675834803240076,-0.15986707294579158,0.65802036299361,0.33701658189477507,1.2059486289837344,-0.07357327446040215,0.6431811538013191,1.0296274822176772,-0.22999085661134913,0.3997325317718629,1.0981470112960925,0.6282990804246098,2.1784605959005607,-2.153721952328721,-0.3914762369552328,-0.373271876429598,-0.26542599868242417,0.14408985151272588,0.32121625895525563,-0.7901703605422196,-1.0335027512907717,-0.1773059016141884,-1.5142922206614813,-0.4280869276823581,0.4616874064468927,-0.596278947334594,-1.0543430004362901,0.09468784334280253,0.5380910558331444,-0.22999085661134913,0.903980231650309,0.19301386899346543,-0.7507725016906376,-0.02250118346835699,-0.1773059016141884,-0.40974773902190176,0.25751962221115077,-0.12517084870498654,-2.180159048860371,1.125305736257329,0.06148252180205109,0.02805701137235168,-0.26542599868242417,1.6287336796515217,1.641034754600386,-0.5208177336190014,0.06148252180205109,-0.26542599868242417,0.41529180787632924,0.11120892157867891,0.02805701137235168,0.7315827923762055,-0.0564914375226667,2.0204818903795823,-0.7901703605422196,-0.2832385860448953,0.19301386899346543,3.0792691433168833,0.7022834886797121,0.6133738705970863,1.750489731196436,-0.33706243340680064,0.09468784334280253,0.33701658189477507,0.20921739577808898,2.310315469590055,1.6655522802639968,-1.701914084340314,1.3636206339195902,0.9180915884762,1.001966258000303,-0.6922649775615227,0.17675834803240076,-0.35513411913799386,0.5833929390939195,0.47705956297724367,0.9601976189085124,1.4534696782308594,-0.03946755021715677,1.8695432160167267,0.06148252180205109,2.1000456604552045,0.24146991514915547,3.256023162941908,0.19301386899346543,-0.24767692023999524,0.8898304908049921,0.7752227411673067,0.30536674022651894,0.7022834886797121,1.3894476706931538,-0.1424888753229872,2.0547236877093185,-0.30111518243997987,1.6287336796515217,1.1657819605638418,0.41529180787632924,0.6133738705970863,0.22536929144369766,0.19301386899346543,2.066089721766653,1.7625145060761207,1.1657819605638418,1.3506596827179598,1.2853737321434007,1.6164042064007391,0.522901157152449,0.522901157152449,0.2735187641595761,0.2735187641595761,0.3841256925736641,-0.7704316844994457,0.9180915884762,1.1925938145223307,-0.22999085661134913,-0.005591913085313469,-0.22999085661134913,-0.31905629408571334,1.2722190787348595,0.47705956297724367,0.65802036299361,1.2192696206606266,0.19301386899346543,-1.075273613042021,0.6875712647067221,1.3765499068522848,-0.0907134950668146,-0.3914762369552328,2.031919882590151,0.7022834886797121,0.5833929390939195,-0.31905629408571334,0.8184979173823138,0.65802036299361,0.5683366593475094,2.606176282501621,-1.1599171531024435 3430 Protein localization 36 77 5.0317728872666105 4.859647573909643e-07 P46379,O75874,Q8TB36,Q9NS69,P21796,O14734,O60830,Q9Y512,O15254,Q13190,P12236,Q10713,O14975,P08574,P50402,P28288,O15228,O43681,Q9Y5J7,Q13505,P09601,O43615,Q15067,Q2T9J0,Q9Y5J9,O14925,P05067,Q99595,Q5JRX3,P12235,A8MXV4,Q8N4H5,P51648,Q9Y584,Q9NR77,Q9Y5L4 Processes and pathways Reactome Pathways msigdb_reactome 256,1,390,7,9,391,20,278,285,541,418,292,424,296,431,555,307,553,571,58,59,565,319,320,193,204,205,78,85,213,350,101,110,119,123,125 350,1184,391,204,424,307,285,565,553,1809,573,20,1056,2833,1010,1532,2381,692,1,1098,1443,205,674,296,3287,59,3180,213,418,2148,9,2261,2925,555,928,2926,3050,739,256,431,2079,1060,110,1194,3390,1968,292,1969,541,58,319,900,320,968,85,1586,101,1040,390,1834,78,3001,1867,123,7,732,1734,1386,708,2660,1350,2171,278,119,571,193,125 1.2325569767034361,0.19301386899346543,1.125305736257329,1.6777690135569574,1.04340337414266,1.3376668826640072,1.3894476706931538,0.7752227411673067,0.7896879996375533,-0.1424888753229872,0.7607169539788241,3.2100435371001237,0.2894676887918951,-0.7901703605422196,0.32121625895525563,-0.005591913085313469,-0.4280869276823581,0.6282990804246098,3.92901774642917,0.25751962221115077,0.04479749007284595,1.6777690135569574,0.6431811538013191,1.3636206339195902,-1.4913543909405875,2.54410242985927,-1.1813127889529935,1.641034754600386,1.057143066123191,-0.30111518243997987,3.489279818123242,-0.35513411913799386,-0.8699343008139493,0.7896879996375533,0.3841256925736641,-0.8699343008139493,-0.992089953515064,0.5833929390939195,1.47886368568901,1.0296274822176772,-0.26542599868242417,0.2894676887918951,2.1784605959005607,0.19301386899346543,-2.153721952328721,-0.2123673195994045,1.3765499068522848,-0.2123673195994045,0.8184979173823138,2.5544966637542177,1.2984956621256847,0.41529180787632924,1.2984956621256847,0.3527680424371989,2.3319852246797077,-0.02250118346835699,2.211724229893288,0.30536674022651894,1.1388325289942267,-0.1424888753229872,2.3750691920218543,-0.9306276139125141,-0.15986707294579158,2.077431989617715,3.602417135580486,0.5984052493734849,-0.0907134950668146,0.09468784334280253,0.6282990804246098,-0.6344483133432426,0.11120892157867891,-0.30111518243997987,1.4151493408700357,2.1113172784145564,0.7752227411673067,1.750489731196436,2.066089721766653 3430 Ion transmembrane transporter activity 52 95 4.924038332162267 8.477621878946214e-07 P20020,P21796,P24539,P51798,Q9UBX3,Q7KZN9,P45880,Q70HW3,P16615,Q13423,Q9UM00,P53985,P30825,O95202,Q9H0U3,Q9C0H2,Q96NB2,Q9Y6M7,P00403,Q9BQT8,P12236,Q9HD20,Q4KMQ2,Q96ES6,P11166,P06576,P08574,Q9Y619,Q9Y487,O75964,Q9H2D1,Q9UJS0,O43681,Q9Y277,Q8TB61,Q15043,Q6NUK1,O75746,P55011,O43808,Q9UDW1,P13073,Q9BXP2,Q6P4Q7,Q00325,P12235,O43772,Q93050,P05023,Q6P4A7,P14854,Q14728 Functions GO Molecular function msigdb_gomf 385,9,138,524,13,525,15,16,269,146,668,271,402,401,536,24,410,548,28,157,418,35,163,37,676,674,296,45,175,47,49,708,553,309,55,191,580,692,574,573,74,336,601,598,214,213,468,220,607,232,363,638 2852,553,468,573,692,3081,47,401,839,28,607,736,674,1221,1952,2146,1567,296,859,840,676,213,418,336,363,269,385,1119,3191,3343,9,819,138,2925,402,784,1257,2149,2748,15,1075,3379,524,1100,271,574,2080,726,1259,1014,214,2464,696,146,638,2974,191,950,163,3386,580,2193,232,598,16,525,996,1130,55,882,220,37,410,792,1552,157,2961,601,24,536,49,1409,942,35,13,74,2136,708,668,309,175,2067,45,3419,548 -0.8099892376198776,0.7896879996375533,0.9462000577616902,0.7607169539788241,0.6282990804246098,-1.0335027512907717,2.748363067010926,1.0981470112960925,0.4616874064468927,3.0698107589013315,0.7169539114401163,0.5833929390939195,0.6431811538013191,0.17675834803240076,-0.2123673195994045,-0.30111518243997987,-0.02250118346835699,1.3636206339195902,0.44626893355334946,0.4616874064468927,0.6431811538013191,1.641034754600386,1.057143066123191,1.2590315225380515,1.1925938145223307,1.4279535786684734,1.1388325289942267,0.24146991514915547,-1.2028041638743916,-1.7500104946959263,3.489279818123242,0.47705956297724367,1.9744867066455778,-0.8699343008139493,1.0981470112960925,0.522901157152449,0.1604504658814682,-0.30111518243997987,-0.7116898323792509,3.2925394092933984,0.2735187641595761,-2.0237575733036444,0.861414936766202,0.25751962221115077,1.4279535786684734,0.7607169539788241,-0.26542599868242417,0.5984052493734849,0.1604504658814682,0.32121625895525563,1.641034754600386,-0.4835161673691688,0.6282990804246098,1.9280968875332776,0.6875712647067221,-0.9103121062691136,1.750489731196436,0.36847097049977656,1.8577557582221775,-2.1012974711813244,0.7607169539788241,-0.31905629408571334,1.5792439505261,0.7315827923762055,3.2651743542921823,0.861414936766202,0.33701658189477507,0.24146991514915547,2.606176282501621,0.43080383738421585,1.6287336796515217,3.0222783212407616,1.0845146796370766,0.522901157152449,-0.005591913085313469,1.8813049364421908,-0.8900812583352817,0.7315827923762055,3.1356876574429107,0.8328430643605732,2.7383268943293446,0.07811250742307049,0.3841256925736641,3.0318170762153325,3.391761695054266,2.4178172840822203,-0.2832385860448953,0.6282990804246098,0.65802036299361,1.3376668826640072,1.8103460646896083,-0.24767692023999524,2.7982738550861823,-3.6748723761247377,0.8184979173823138 3430 Anion transport 41 67 4.817090102378592 1.4566692139172943e-06 P30536,Q9NP80,P21796,P51798,Q9UBX3,P45880,P53985,P30825,Q15907,P04083,Q9C0H2,Q96NB2,Q9Y6M7,Q9BQT8,P08183,P12236,Q4KMQ2,P07602,P11166,Q9Y619,Q9H2D1,P28288,Q9UJS0,O43681,Q9Y277,Q8TB61,Q9UHG3,Q15043,Q6NUK1,O75746,Q02978,P55011,O43808,Q15041,Q9NZJ7,Q9BXP2,Q00325,P12235,O43865,P05141,Q14728 Processes and pathways GO Biological process msigdb_gobp 2,264,9,524,13,15,271,402,276,148,24,410,548,157,159,418,163,38,676,45,49,555,708,553,309,55,57,191,580,692,696,574,573,713,341,601,214,213,469,736,638 2852,553,573,469,2408,692,1507,839,148,736,1607,38,159,1567,859,676,213,418,1223,2073,9,555,2,402,15,524,1100,271,1856,574,1918,214,696,1228,638,713,1488,191,950,276,163,3386,580,2193,996,55,410,792,1552,157,601,24,1555,49,1409,942,264,341,13,57,760,708,309,2404,45,3419,548 -0.8099892376198776,0.7896879996375533,0.7607169539788241,0.9462000577616902,-0.4464943548499513,0.6282990804246098,0.01126068031324202,0.4616874064468927,1.904751655596212,0.5833929390939195,-0.03946755021715677,3.0127233121243298,1.8695432160167267,-0.02250118346835699,0.44626893355334946,0.6431811538013191,1.641034754600386,1.057143066123191,0.17675834803240076,-0.26542599868242417,3.489279818123242,0.7896879996375533,3.92901774642917,1.0981470112960925,3.2925394092933984,0.861414936766202,0.25751962221115077,1.4279535786684734,-0.15986707294579158,0.7607169539788241,-0.1948058268211105,1.641034754600386,0.6282990804246098,0.17675834803240076,0.6875712647067221,0.6133738705970863,0.02805701137235168,1.750489731196436,0.36847097049977656,1.4151493408700357,1.8577557582221775,-2.1012974711813244,0.7607169539788241,-0.31905629408571334,0.33701658189477507,2.606176282501621,1.0845146796370766,0.522901157152449,-0.005591913085313469,1.8813049364421908,0.7315827923762055,3.1356876574429107,-0.005591913085313469,2.7383268943293446,0.07811250742307049,0.3841256925736641,1.4534696782308594,1.2590315225380515,3.391761695054266,2.5648713543162147,0.5683366593475094,0.6282990804246098,1.3376668826640072,-0.4280869276823581,2.7982738550861823,-3.6748723761247377,0.8184979173823138 3430 Lysosome 23 50 4.762281362195986 1.914165393968048e-06 P06865,P06280,P50897,P08236,P04062,O14773,P07602,P16278,Q9Y487,P10253,Q14108,P17900,Q9NZJ7,Q99519,P15586,P54802,Q8NCC3,Q93050,P10619,O75503,P13473,O15118,Q13510 Processes and pathways KEGG Pathways msigdb_kegg 268,275,22,279,30,162,38,43,175,311,60,66,341,340,206,87,91,220,226,104,237,109,250 2026,977,2347,162,109,553,2501,104,30,895,275,268,38,1358,279,3126,3233,311,226,370,646,1509,237,983,206,43,66,1147,2183,22,87,1259,512,1783,2557,250,60,490,91,1208,220,340,600,1941,341,2136,2104,3278,617,175 -0.24767692023999524,0.33701658189477507,-0.40974773902190176,1.8577557582221775,2.1784605959005607,0.7896879996375533,-0.5208177336190014,2.189571052524327,3.0603364192521147,0.41529180787632924,1.4151493408700357,1.4279535786684734,3.0127233121243298,0.09468784334280253,1.402314093228658,-1.096295452188383,-1.3117306703903504,1.3246420617522143,1.6040461907838122,1.179204988513675,0.6728169776242082,0.01126068031324202,1.554325783520826,0.33701658189477507,1.6777690135569574,2.9065277890482055,2.4918352621956807,0.22536929144369766,-0.31905629408571334,3.191546309151074,2.321161071650228,0.1604504658814682,0.8756421363992508,-0.12517084870498654,-0.558403728184664,1.5041368739934033,2.5336885717746562,0.9180915884762,2.277649032464161,0.19301386899346543,1.6287336796515217,1.2590315225380515,0.7315827923762055,-0.1948058268211105,1.2590315225380515,-0.2832385860448953,-0.26542599868242417,-1.445808727840182,0.7169539114401163,1.8103460646896083 3430 Lysosomal lumen 22 36 4.761029714118096 1.926076842906354e-06 P38435,P06865,P06280,P50897,P08236,P04062,O14773,P07602,P16278,Q9UM22,Q8NHP8,P10253,Q14108,P17900,Q9NZJ7,Q99519,P15586,P54802,P10619,P13473,Q8IV08,Q13510 Localization GO Cellular component msigdb_gocc 136,268,275,22,279,30,162,38,43,51,53,311,60,66,341,340,206,87,226,237,120,250 467,977,162,553,30,895,275,268,38,1358,656,279,311,226,370,2108,237,983,206,43,66,136,2183,775,22,87,512,250,60,120,2055,53,340,1066,341,51 0.9462000577616902,0.33701658189477507,1.8577557582221775,0.7896879996375533,3.0603364192521147,0.41529180787632924,1.4151493408700357,1.4279535786684734,3.0127233121243298,0.09468784334280253,0.65802036299361,1.402314093228658,1.3246420617522143,1.6040461907838122,1.179204988513675,-0.2832385860448953,1.554325783520826,0.33701658189477507,1.6777690135569574,2.9065277890482055,2.4918352621956807,1.9975331678372859,-0.31905629408571334,0.5380910558331444,3.191546309151074,2.321161071650228,0.8756421363992508,1.5041368739934033,2.5336885717746562,2.1000456604552045,-0.24767692023999524,2.6369536602330523,1.2590315225380515,0.2894676887918951,1.2590315225380515,2.677725710562994 3430 Organic anion transport 26 43 4.739580566015254 2.141610703887409e-06 Q9NP80,Q9UBX3,P53985,P30825,P04083,Q96NB2,Q9Y6M7,Q9BQT8,P12236,P07602,P11166,Q9Y619,Q9H2D1,P28288,Q9UJS0,Q8TB61,Q6NUK1,O75746,Q02978,P55011,O43808,Q15041,Q9NZJ7,P12235,P05141,Q14728 Processes and pathways GO Biological process msigdb_gobp 264,13,271,402,148,410,548,157,418,38,676,45,49,555,708,55,580,692,696,574,573,713,341,213,736,638 573,2408,692,1507,839,148,736,1607,38,1567,676,213,418,1223,2073,555,402,1100,271,574,1918,696,638,713,1488,950,580,2193,996,55,410,1552,157,49,1409,942,264,341,13,760,708,45,548 0.7607169539788241,-0.4464943548499513,0.6282990804246098,0.01126068031324202,0.4616874064468927,1.904751655596212,0.5833929390939195,-0.03946755021715677,3.0127233121243298,-0.02250118346835699,0.6431811538013191,1.641034754600386,1.057143066123191,0.17675834803240076,-0.26542599868242417,0.7896879996375533,1.0981470112960925,0.25751962221115077,1.4279535786684734,0.7607169539788241,-0.1948058268211105,0.6282990804246098,0.6875712647067221,0.6133738705970863,0.02805701137235168,0.36847097049977656,0.7607169539788241,-0.31905629408571334,0.33701658189477507,2.606176282501621,1.0845146796370766,-0.005591913085313469,1.8813049364421908,2.7383268943293446,0.07811250742307049,0.3841256925736641,1.4534696782308594,1.2590315225380515,3.391761695054266,0.5683366593475094,0.6282990804246098,2.7982738550861823,0.8184979173823138 3430 Intrinsic component of plasma membrane 43 78 4.7268138129398345 2.2807020818582657e-06 P20020,O76062,Q13641,Q8NAN2,O14786,Q9UIQ6,P36551,P11279,O96005,O00560,P10321,O00264,P16615,P53985,P35613,P30825,Q9H0U3,Q99797,P11166,Q8WTV0,O95864,Q9UJS0,Q9NR28,O43657,Q15043,P51572,P55011,Q02978,Q9BTU6,P05067,Q9Y4G8,Q00325,P12235,P27824,Q92542,P78310,P05023,P05141,O15118,P01889,Q14BN4,P04439,O60637 Localization GO Cellular component msigdb_gocc 385,382,388,134,520,137,647,646,140,266,393,143,269,271,270,402,536,290,676,169,554,708,705,63,191,694,574,696,587,205,734,214,213,725,612,608,607,736,109,369,624,244,126 856,143,266,520,3148,945,1738,109,959,63,126,382,554,140,369,1314,244,607,205,736,1607,1221,2965,393,873,676,646,1509,213,269,2619,385,1147,2457,819,725,402,1781,270,647,694,271,1574,574,608,214,696,2364,1578,743,3035,388,624,191,2237,950,1621,996,1494,134,1041,169,612,290,1552,1590,1211,587,3422,536,2521,705,1245,1596,137,708,956,734 0.44626893355334946,1.9513415899455118,1.4407269703301229,0.861414936766202,-1.1386163266404463,0.36847097049977656,-0.10791253841717666,2.1784605959005607,0.3527680424371989,2.5128016570172145,2.0547236877093185,1.1523245386286525,0.7896879996375533,1.9629265380559953,1.179204988513675,0.1276761298241045,1.5292904957224467,0.7169539114401163,1.6777690135569574,0.5833929390939195,-0.03946755021715677,0.17675834803240076,-0.9103121062691136,1.125305736257329,0.43080383738421585,0.6431811538013191,0.6728169776242082,0.01126068031324202,1.641034754600386,1.4279535786684734,-0.6153265492951593,1.1388325289942267,0.22536929144369766,-0.4835161673691688,0.47705956297724367,0.5984052493734849,1.0981470112960925,-0.12517084870498654,1.4279535786684734,0.6728169776242082,0.6282990804246098,1.4279535786684734,-0.02250118346835699,0.7607169539788241,0.7169539114401163,1.641034754600386,0.6282990804246098,-0.40974773902190176,-0.02250118346835699,0.5833929390939195,-0.971515740451046,1.1388325289942267,0.7022834886797121,1.750489731196436,-0.33706243340680064,0.36847097049977656,-0.03946755021715677,0.33701658189477507,0.02805701137235168,2.0090196896501236,0.30536674022651894,1.8459424393187207,0.7169539114401163,1.3894476706931538,-0.005591913085313469,-0.02250118346835699,0.19301386899346543,0.7461703883999292,-3.980876334866757,0.8328430643605732,-0.5208177336190014,0.6282990804246098,0.17675834803240076,-0.02250118346835699,1.9975331678372859,0.6282990804246098,0.36847097049977656,0.5984052493734849 3430 Membrane lipid metabolic process 20 37 4.664584304398999 3.092415346017674e-06 Q06136,P06865,O60512,P06280,P50897,P04062,O15269,P07602,Q9P035,O15270,P16278,P22059,O43292,P17900,Q9NZJ7,O95470,Q8NCC3,Q8NBX0,Q13510,Q96G23 Processes and pathways GO Biological process msigdb_gobp 258,268,18,275,22,30,286,38,294,295,43,316,194,66,341,86,91,95,250,124 286,295,194,18,605,86,30,895,275,268,38,1358,43,66,316,501,795,22,2511,258,988,250,951,95,91,1083,1378,124,2761,340,1085,640,591,641,341,294,1734 1.3894476706931538,1.3636206339195902,1.738437938975464,3.237676205824806,0.7169539114401163,2.321161071650228,3.0603364192521147,0.41529180787632924,1.4151493408700357,1.4279535786684734,3.0127233121243298,0.09468784334280253,2.9065277890482055,2.4918352621956807,1.2984956621256847,0.8898304908049921,0.5076661391022604,3.191546309151074,-0.5208177336190014,1.4661818634308703,0.33701658189477507,1.5041368739934033,0.36847097049977656,2.244786155021276,2.277649032464161,0.2735187641595761,0.09468784334280253,2.066089721766653,-0.7116898323792509,1.2590315225380515,0.2735187641595761,0.6875712647067221,0.7461703883999292,0.6875712647067221,1.2590315225380515,1.3765499068522848,-0.0907134950668146 3430 Anion transmembrane transport 27 40 4.640049919367094 3.48325025845142e-06 P21796,P51798,Q9UBX3,P45880,P53985,P30825,Q96NB2,Q9Y6M7,Q9BQT8,P08183,P12236,Q4KMQ2,Q9Y619,Q9H2D1,Q9UJS0,Q9Y277,Q8TB61,Q9UHG3,O75746,Q02978,P55011,O43808,Q15041,Q9BXP2,Q00325,P12235,Q14728 Processes and pathways GO Biological process msigdb_gobp 9,524,13,15,271,402,410,548,157,159,418,163,45,49,708,309,55,57,692,696,574,573,713,601,214,213,638 573,2408,692,1507,839,736,1607,159,1567,213,418,9,402,15,524,1100,271,574,214,696,1228,638,713,950,163,996,55,410,157,601,49,1409,942,13,57,708,309,2404,45,548 0.7607169539788241,-0.4464943548499513,0.6282990804246098,0.01126068031324202,0.4616874064468927,0.5833929390939195,-0.03946755021715677,1.8695432160167267,-0.02250118346835699,1.641034754600386,1.057143066123191,3.489279818123242,1.0981470112960925,3.2925394092933984,0.861414936766202,0.25751962221115077,1.4279535786684734,0.7607169539788241,1.641034754600386,0.6282990804246098,0.17675834803240076,0.6875712647067221,0.6133738705970863,0.36847097049977656,1.8577557582221775,0.33701658189477507,2.606176282501621,1.0845146796370766,1.8813049364421908,0.7315827923762055,2.7383268943293446,0.07811250742307049,0.3841256925736641,3.391761695054266,2.5648713543162147,0.6282990804246098,1.3376668826640072,-0.4280869276823581,2.7982738550861823,0.8184979173823138 3430 Ion transmembrane transport 69 154 4.618400013374302 3.867102377874687e-06 Q99623,O75027,P20020,P27695,P21796,P24539,P51798,Q7KZN9,Q9UBX3,P45880,Q70HW3,P16615,Q13423,Q9UM00,P53985,P30825,P31930,O95202,Q9H0U3,Q9C0H2,Q96NB2,Q9Y6M7,P00403,Q9BQT8,O75844,P08183,P12236,Q9HD20,Q4KMQ2,Q96ES6,P06576,P08574,Q9Y619,O75964,Q9H2D1,Q9UJS0,Q9Y277,Q8TB61,Q9UHG3,Q96GC9,Q15043,O75746,P42858,P55011,Q02978,O43808,Q9UDW1,Q06787,P05067,Q15041,P13073,Q96PU5,Q9BXP2,Q6P4Q7,Q00325,P12235,O43772,P56385,Q8IYU8,O43865,P05023,P46934,Q9HD47,Q6P4A7,P05141,P14854,Q14BN4,Q9NUT2,Q14728 Processes and pathways GO Biological process msigdb_gobp 517,763,385,774,9,138,524,525,13,15,16,269,146,668,271,402,784,401,536,24,410,548,28,157,32,159,418,35,163,37,674,296,45,47,49,708,309,55,57,188,191,692,447,574,696,573,74,203,205,713,336,211,601,598,214,213,468,726,347,469,607,103,106,232,736,363,624,519,638 2852,1772,1950,781,468,573,469,2832,2408,763,3007,1441,2031,1532,692,32,1507,3081,47,401,839,28,607,205,736,1607,674,1221,1952,3082,2146,159,1567,296,859,2965,840,3301,213,418,336,363,269,1444,2109,3303,2504,385,1119,3191,3343,3127,9,819,138,2925,774,2640,2598,3166,402,784,3167,1257,2149,2748,447,15,103,1396,1075,3379,1192,524,1100,271,1573,1574,574,2080,726,1259,1014,2555,1121,214,2464,696,2187,203,988,3204,1716,146,1228,1669,1670,638,2974,624,713,191,2237,950,163,232,598,1039,16,525,996,2161,347,1863,1130,55,1236,882,37,188,1499,410,211,3387,517,1590,157,2961,601,24,536,49,2370,1409,942,35,106,519,1092,13,74,2687,57,2136,708,1530,668,309,2345,2404,1025,45,3419,548 -0.8099892376198776,-0.12517084870498654,-0.2123673195994045,0.522901157152449,0.9462000577616902,0.7607169539788241,0.9462000577616902,-0.7901703605422196,-0.4464943548499513,0.5532361269354006,-0.9510285615071858,0.04479749007284595,-0.24767692023999524,-0.005591913085313469,0.6282990804246098,3.050846065270086,0.01126068031324202,-1.0335027512907717,2.748363067010926,1.0981470112960925,0.4616874064468927,3.0698107589013315,0.7169539114401163,1.6777690135569574,0.5833929390939195,-0.03946755021715677,0.6431811538013191,0.17675834803240076,-0.2123673195994045,-1.0335027512907717,-0.30111518243997987,1.8695432160167267,-0.02250118346835699,1.3636206339195902,0.44626893355334946,-0.9103121062691136,0.4616874064468927,-1.5373416114687155,1.641034754600386,1.057143066123191,1.2590315225380515,1.1925938145223307,1.4279535786684734,0.04479749007284595,-0.2832385860448953,-1.5373416114687155,-0.5208177336190014,1.1388325289942267,0.24146991514915547,-1.2028041638743916,-1.7500104946959263,-1.096295452188383,3.489279818123242,0.47705956297724367,1.9744867066455778,-0.8699343008139493,0.5380910558331444,-0.6344483133432426,-0.596278947334594,-1.1599171531024435,1.0981470112960925,0.522901157152449,-1.1599171531024435,0.1604504658814682,-0.30111518243997987,-0.7116898323792509,1.001966258000303,3.2925394092933984,2.2006588969869694,0.07811250742307049,0.2735187641595761,-2.0237575733036444,0.19301386899346543,0.861414936766202,0.25751962221115077,1.4279535786684734,-0.02250118346835699,-0.02250118346835699,0.7607169539788241,-0.26542599868242417,0.5984052493734849,0.1604504658814682,0.32121625895525563,-0.558403728184664,0.24146991514915547,1.641034754600386,-0.4835161673691688,0.6282990804246098,-0.31905629408571334,1.7021191193583658,0.33701658189477507,-1.2243922216969028,-0.0907134950668146,1.9280968875332776,0.17675834803240076,-0.07357327446040215,-0.07357327446040215,0.6875712647067221,-0.9103121062691136,0.7022834886797121,0.6133738705970863,1.750489731196436,-0.33706243340680064,0.36847097049977656,1.8577557582221775,1.5792439505261,0.7315827923762055,0.30536674022651894,3.2651743542921823,0.861414936766202,0.33701658189477507,-0.30111518243997987,1.2458108826688405,-0.15986707294579158,0.24146991514915547,2.606176282501621,0.17675834803240076,0.43080383738421585,3.0222783212407616,1.7625145060761207,0.02805701137235168,1.0845146796370766,1.6655522802639968,-2.1012974711813244,0.8756421363992508,-0.02250118346835699,1.8813049364421908,-0.8900812583352817,0.7315827923762055,3.1356876574429107,0.8328430643605732,2.7383268943293446,-0.40974773902190176,0.07811250742307049,0.3841256925736641,3.0318170762153325,2.189571052524327,0.8756421363992508,0.2735187641595761,3.391761695054266,2.4178172840822203,-0.6536448751928122,2.5648713543162147,-0.2832385860448953,0.6282990804246098,0.01126068031324202,0.65802036299361,1.3376668826640072,-0.3914762369552328,-0.4280869276823581,0.32121625895525563,2.7982738550861823,-3.6748723761247377,0.8184979173823138 3430 Ion transport 88 210 4.582058119795409 4.604218803772042e-06 Q99623,P30536,P21796,P51798,Q7KZN9,Q9UBX3,P45880,Q70HW3,Q9H0U3,Q9C0H2,Q9Y6M7,P00403,O75844,Q9HD20,Q96ES6,P07602,Q9Y619,O75964,Q9H2D1,P28288,O43681,Q8TB61,Q9UHG3,Q6NUK1,P55011,O43808,Q99959,Q9UDW1,Q9BXP2,Q6P4Q7,O15173,P05023,P46934,Q9HD47,O14936,Q14BN4,Q14728,P24539,Q13423,Q9UM00,P04083,Q9BQT8,P08183,Q4KMQ2,P11166,P06576,Q9UJS0,Q96GC9,Q15043,O75746,Q02978,Q06787,P05067,Q15041,Q96PU5,Q00325,P12235,P56385,Q6P4A7,P05141,Q9UHQ9,O75027,P27695,Q9NP80,Q96S66,P16615,P53985,Q15907,P31930,P08574,Q9Y277,P61586,Q9NZJ7,P13073,Q8IYU8,P14854,P20020,P30825,O95202,Q96NB2,P12236,P33176,Q8NE01,P42858,O43772,O43865,O76024,Q9NUT2 Processes and pathways GO Biological process msigdb_gobp 517,2,9,524,525,13,15,16,536,24,548,28,32,35,37,38,45,47,49,555,553,55,57,580,574,573,586,74,601,598,99,607,103,106,604,624,638,138,146,668,148,157,159,163,676,674,708,188,191,692,696,203,205,713,211,214,213,726,232,736,760,763,774,264,792,269,271,276,784,296,309,337,341,336,347,363,385,402,401,410,418,425,432,447,468,469,477,519 2852,1772,1559,1950,2816,604,99,553,781,468,573,469,2832,2408,763,3007,1441,2031,2693,1532,692,32,1507,3081,47,477,401,1639,839,1443,28,1314,148,1220,607,205,736,1607,963,674,1221,1952,3082,38,2146,159,1567,296,859,2965,840,676,2411,3301,213,418,336,3047,1223,947,363,269,1444,2109,3303,1316,2504,385,1610,1119,3191,3343,3127,2073,9,819,138,1570,2925,774,2640,555,2598,2,3166,402,784,2076,425,1190,3167,1257,2149,2748,447,15,2835,103,1396,1075,3379,1192,524,1011,1100,271,1856,1573,1574,574,2080,726,2042,1259,337,1014,2555,1121,1918,214,2464,1783,1577,696,2187,203,988,3253,3204,1716,146,1228,1337,1669,1670,638,2974,624,713,1488,191,2237,950,276,1673,163,3386,580,2193,232,598,1039,16,525,996,2161,347,1863,432,1130,55,1236,882,37,188,1499,410,211,792,3387,517,1552,586,1590,157,2961,601,24,1555,536,49,2370,1409,942,35,106,264,3429,519,341,1092,13,74,2687,57,760,2136,708,1530,2250,668,2964,1632,309,2345,2404,1025,45,3419,548 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3430 Lipid metabolic process 110 294 4.546397592058179 5.457190360935726e-06 Q9BQE5,Q99623,O75874,P30536,P61916,O60512,Q16134,P50897,Q15392,Q8NCG7,Q14849,P04062,O75844,P23786,P07602,Q9HB40,Q96SU4,P16278,P28288,O95864,O43681,Q8NHP8,A1L0T0,O75477,Q6IAN0,P17900,O43808,P54646,Q9BTU6,Q9NWU1,Q9NXE4,Q86UY6,O95470,Q15800,Q8NCC3,Q9NPH0,Q8NBX0,P05023,O60762,P51648,Q9UBM7,O15118,Q14534,Q16836,Q9H490,Q96G23,P38435,P07099,Q06520,P04083,O14773,Q8N2A8,P37268,Q8WTV0,Q96N66,O43292,P05067,Q16850,Q6NUM9,Q14739,P52429,P16435,Q8TBX8,Q13510,P35610,Q06136,O14678,Q53GQ0,Q9NP80,P53985,P06865,P06280,Q96K12,P21964,O15254,Q14457,Q2TAA5,O15269,Q10713,Q9P035,O15270,Q9BWD1,O15228,P22059,Q15067,Q2T9J0,Q15118,Q9NZJ7,Q99519,A8MXV4,P42345,P48651,Q9NUQ2,O76062,Q15120,Q9UBV2,O14734,Q13315,O14975,P46108,Q86YN1,Q9BZF1,Q709F0,O75845,Q9H7Z7,Q9UG56,Q8N4Q0,Q9BT22,P27544,Q8NF37 Processes and pathways GO Biological process msigdb_gobp 0,517,1,2,512,18,533,22,23,534,27,30,32,33,38,40,564,43,555,554,553,53,54,566,579,66,573,75,587,590,591,80,86,88,91,94,95,607,605,110,632,109,122,625,640,124,136,141,144,148,162,164,166,169,189,194,205,210,216,222,228,231,242,250,252,258,257,262,264,271,268,275,283,280,285,287,288,286,292,294,295,304,307,316,319,320,329,341,340,350,353,360,367,382,389,397,391,400,424,429,453,458,457,470,474,487,492,494,501,506 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3430 Intrinsic component of endoplasmic reticulum membrane 35 54 4.544262311446566 5.512797346174381e-06 P57088,Q9NZ01,P10321,O00767,Q99442,Q9UM00,Q9HCU5,Q86XL3,Q8TCT9,O75844,Q9P035,O14975,Q8TB61,Q9Y4P3,Q9NPA0,O43292,P51572,Q86YN1,Q15041,Q03519,Q6NTF9,O95470,Q03518,P27824,O76024,Q9Y282,Q9NQC3,Q9BUN8,Q9UBM7,P01889,P04439,Q15629,Q96A33,Q9H490,O76062 Localization GO Cellular component msigdb_gocc 511,641,393,644,793,668,665,161,289,32,294,424,55,313,703,194,694,453,713,215,597,86,218,725,477,102,359,366,632,369,244,116,379,640,382 856,644,424,926,194,32,477,382,86,369,244,393,3064,725,2641,694,511,1014,218,215,2840,1618,713,116,790,597,1621,161,453,1426,55,289,1083,1378,379,2761,793,2830,366,2018,1554,640,665,703,359,641,294,2446,2343,632,668,102,313,1771 0.44626893355334946,0.6728169776242082,1.04340337414266,0.3841256925736641,1.738437938975464,3.050846065270086,0.9321647887240839,1.1523245386286525,2.321161071650228,1.179204988513675,1.5292904957224467,1.125305736257329,-1.0127520150653435,0.5984052493734849,-0.6344483133432426,0.6282990804246098,0.8756421363992508,0.32121625895525563,1.6287336796515217,1.641034754600386,-0.7901703605422196,-0.03946755021715677,0.6133738705970863,2.133790611209967,0.522901157152449,0.7315827923762055,-0.03946755021715677,1.8695432160167267,0.98808050071691,0.06148252180205109,2.606176282501621,1.3894476706931538,0.2735187641595761,0.09468784334280253,1.1657819605638418,-0.7116898323792509,0.522901157152449,-0.7704316844994457,1.1925938145223307,-0.22999085661134913,-0.005591913085313469,0.6875712647067221,0.65802036299361,0.6282990804246098,1.2192696206606266,0.6875712647067221,1.3765499068522848,-0.4649705794159142,-0.3914762369552328,0.7022834886797121,0.65802036299361,2.211724229893288,1.3246420617522143,-0.10791253841717666 3430 SLC superfamily of solute carriers 29 41 4.540008159271654 5.625205137027578e-06 Q9UBX3,Q70HW3,Q9Y6C9,P53985,P30825,O95202,Q9H0U3,Q96NB2,Q9Y6M7,Q9BQT8,P12236,P11166,O14975,Q9Y619,Q9H2V7,Q9H2D1,Q9UJS0,Q8TB61,Q9BSK2,Q15043,Q6NUK1,O75746,P55011,O43808,Q9NZJ7,Q9BXP2,Q00325,O43772,P12235 Drugs and Diseases Pharos Drug Target Ontology pharos_dto 13,16,145,271,402,401,536,410,548,157,418,676,424,45,46,49,708,55,61,191,580,692,574,573,341,601,214,468,213 424,468,573,692,401,839,736,1567,676,213,418,402,1100,271,574,214,696,191,950,3386,580,2193,16,798,55,410,1552,157,61,601,536,49,46,1409,942,341,13,708,45,145,548 1.04340337414266,0.9462000577616902,0.7607169539788241,0.6282990804246098,1.0981470112960925,0.4616874064468927,0.5833929390939195,-0.02250118346835699,0.6431811538013191,1.641034754600386,1.057143066123191,1.0981470112960925,0.25751962221115077,1.4279535786684734,0.7607169539788241,1.641034754600386,0.6282990804246098,1.750489731196436,0.36847097049977656,-2.1012974711813244,0.7607169539788241,-0.31905629408571334,3.2651743542921823,0.5076661391022604,2.606176282501621,1.0845146796370766,-0.005591913085313469,1.8813049364421908,2.5336885717746562,0.7315827923762055,0.8328430643605732,2.7383268943293446,2.7583811399319984,0.07811250742307049,0.3841256925736641,1.2590315225380515,3.391761695054266,0.6282990804246098,2.7982738550861823,1.9397317456196084,0.8184979173823138 3430 Vacuolar lumen 29 66 4.53543140492151 5.74858599566852e-06 P38435,O00560,P06865,P06280,P50897,P08236,P04062,O14773,P07602,P16278,Q92820,Q9Y5Z4,Q9UM22,Q8NHP8,P10253,P07437,Q14108,P17900,Q9BTY2,Q9NZJ7,Q99519,P15586,Q9H7Z7,P54802,P10619,P13473,P11117,Q8IV08,Q13510 Localization GO Cellular component msigdb_gocc 136,266,268,275,22,279,30,162,38,43,433,50,51,53,311,310,60,66,202,341,340,206,474,87,226,237,370,120,250 266,467,977,162,553,1876,30,895,275,268,1952,310,38,1358,656,279,311,226,370,2108,1955,237,983,206,43,66,2800,3344,136,2183,775,2928,22,3270,1855,3105,87,2387,2463,512,787,1644,2648,3107,2511,1335,250,60,2298,120,2055,53,433,1155,3109,340,1938,1304,202,1066,474,3021,341,51,2740,50 1.4407269703301229,0.9462000577616902,0.33701658189477507,1.8577557582221775,0.7896879996375533,-0.1773059016141884,3.0603364192521147,0.41529180787632924,1.4151493408700357,1.4279535786684734,-0.2123673195994045,1.3246420617522143,3.0127233121243298,0.09468784334280253,0.65802036299361,1.402314093228658,1.3246420617522143,1.6040461907838122,1.179204988513675,-0.2832385860448953,-0.2123673195994045,1.554325783520826,0.33701658189477507,1.6777690135569574,2.9065277890482055,2.4918352621956807,-0.7507725016906376,-1.7500104946959263,1.9975331678372859,-0.31905629408571334,0.5380910558331444,-0.8699343008139493,3.191546309151074,-1.4231985981949864,-0.15986707294579158,-1.0543430004362901,2.321161071650228,-0.4280869276823581,-0.4835161673691688,0.8756421363992508,0.522901157152449,-0.0564914375226667,-0.6344483133432426,-1.0543430004362901,-0.5208177336190014,0.11120892157867891,1.5041368739934033,2.5336885717746562,-0.373271876429598,2.1000456604552045,-0.24767692023999524,2.6369536602330523,1.0296274822176772,0.22536929144369766,-1.0543430004362901,1.2590315225380515,-0.1948058268211105,0.14408985151272588,1.7142527679704935,0.2894676887918951,0.9462000577616902,-0.9510285615071858,1.2590315225380515,2.677725710562994,-0.6922649775615227,2.68787200548125 3430 Active transmembrane transporter activity 35 74 4.474345510373875 7.664571925358743e-06 P20020,P51970,O14678,P51798,Q7KZN9,Q9UBX3,P16615,P53985,O95168,O95202,O43676,Q9Y6M7,P00403,Q9P0J0,O75306,P08183,P12236,Q9HD20,Q96ES6,P08574,P28288,Q15043,Q9Y6M9,P55011,P03886,Q9UDW1,P13073,Q9BXP2,Q03519,Q00325,P12235,Q03518,P05023,P14854,Q9NUT2 Functions GO Molecular function msigdb_gomf 385,386,257,524,525,13,269,271,529,401,21,548,28,158,413,159,418,35,37,296,555,191,326,574,73,74,336,601,215,214,213,218,607,363,519 892,1950,257,926,21,2922,763,1441,413,978,671,1442,529,3008,401,2033,606,28,73,607,736,674,159,1567,296,840,213,418,336,363,269,2639,385,1119,3191,3343,819,555,3031,784,2149,2748,1075,3152,524,386,1100,271,574,1259,214,696,218,215,191,900,950,3131,1673,525,1130,37,601,1409,35,2445,519,158,13,74,2136,2067,548,326 0.41529180787632924,-0.2123673195994045,1.4661818634308703,0.3841256925736641,3.200802504118346,-0.8699343008139493,0.5532361269354006,0.04479749007284595,1.07084676596474,0.33701658189477507,0.6431811538013191,0.04479749007284595,0.8471486580863727,-0.9510285615071858,1.0981470112960925,-0.24767692023999524,0.7169539114401163,3.0698107589013315,2.4178172840822203,0.7169539114401163,0.5833929390939195,0.6431811538013191,1.8695432160167267,-0.02250118346835699,1.3636206339195902,0.4616874064468927,1.641034754600386,1.057143066123191,1.2590315225380515,1.1925938145223307,1.4279535786684734,-0.6344483133432426,1.1388325289942267,0.24146991514915547,-1.2028041638743916,-1.7500104946959263,0.47705956297724367,0.7896879996375533,-0.971515740451046,0.522901157152449,-0.30111518243997987,-0.7116898323792509,0.2735187641595761,-1.1386163266404463,0.861414936766202,1.1388325289942267,0.25751962221115077,1.4279535786684734,0.7607169539788241,0.1604504658814682,1.641034754600386,0.6282990804246098,1.6287336796515217,1.641034754600386,1.750489731196436,0.41529180787632924,0.36847097049977656,-1.096295452188383,-0.07357327446040215,0.861414936766202,0.24146991514915547,3.0222783212407616,0.7315827923762055,0.07811250742307049,3.0318170762153325,-0.4649705794159142,0.8756421363992508,1.8813049364421908,3.391761695054266,2.4178172840822203,-0.2832385860448953,-0.24767692023999524,0.8184979173823138,1.2853737321434007 3430 Mitochondrial transport 23 85 4.400740742225707 1.0788196088018507e-05 P30536,Q9NS69,P24539,Q9UBX3,P45880,O60830,Q9Y512,Q14849,Q9P0J0,P23786,Q99797,O14737,O75964,Q9Y5Z4,Q15070,Q9Y5J9,O14925,Q99595,Q5JRX3,P12235,Q8N4H5,Q9Y584,Q9Y5L4 Processes and pathways GO Biological process msigdb_gobp 2,7,138,13,15,20,278,27,158,33,290,165,47,50,181,193,204,78,85,213,101,119,125 2173,165,204,565,468,20,1603,1010,1532,3081,47,1098,2898,803,3286,414,1443,1877,736,674,656,1878,3180,213,2260,33,138,2925,2598,2505,2,3218,1257,2776,15,3379,2699,677,2040,1058,694,510,575,2080,726,2673,988,292,27,181,900,3016,968,951,85,580,1795,1521,997,101,390,1236,701,3158,885,78,290,889,1867,2445,7,158,3307,13,1114,708,1530,1350,3222,278,119,571,193,125,50 -0.31905629408571334,1.8459424393187207,1.6777690135569574,0.7752227411673067,0.9462000577616902,3.2100435371001237,-0.03946755021715677,0.32121625895525563,-0.005591913085313469,-1.0335027512907717,2.748363067010926,0.25751962221115077,-0.8498704751461239,0.4923857069491886,-1.4913543909405875,1.07084676596474,0.04479749007284595,-0.1773059016141884,0.5833929390939195,0.6431811538013191,0.65802036299361,-0.1773059016141884,-1.1813127889529935,1.641034754600386,-0.35513411913799386,3.0318170762153325,1.9744867066455778,-0.8699343008139493,-0.596278947334594,-0.5208177336190014,3.92901774642917,-1.267862233870033,0.1604504658814682,-0.7311921139115007,3.2925394092933984,-2.0237575733036444,-0.6729168790091554,0.6431811538013191,-0.24767692023999524,0.2894676887918951,0.6282990804246098,0.8756421363992508,0.7607169539788241,-0.26542599868242417,0.5984052493734849,-0.6536448751928122,0.33701658189477507,1.3765499068522848,3.0792691433168833,1.7864835322979642,0.41529180787632924,-0.9510285615071858,0.3527680424371989,0.36847097049977656,2.3319852246797077,0.7607169539788241,-0.12517084870498654,0.01126068031324202,0.33701658189477507,2.211724229893288,1.1388325289942267,0.17675834803240076,0.6282990804246098,-1.1386163266404463,0.43080383738421585,2.3750691920218543,1.3894476706931538,0.43080383738421585,-0.15986707294579158,-0.4649705794159142,3.602417135580486,1.8813049364421908,-1.5373416114687155,3.391761695054266,0.25751962221115077,0.6282990804246098,0.01126068031324202,0.11120892157867891,-1.267862233870033,1.4151493408700357,2.1113172784145564,0.7752227411673067,1.750489731196436,2.066089721766653,2.68787200548125 3430 Cognitive impairment 50 176 4.333434020881012 1.4680129079014392e-05 Q9BQE5,Q13315,P06865,Q9Y2R0,P06280,P50897,Q99720,P21964,P00403,P04062,O95831,O75306,Q10713,P07602,P16278,Q9Y619,Q9Y487,Q9NZ08,Q14108,Q9Y287,P04350,P42858,P17900,Q9NPL8,P31483,P03886,Q06787,P05067,Q9NZJ7,Q13535,Q6DKK2,O95470,P54802,P12235,O75569,P22626,P42345,Q9Y2Z2,O76024,Q96RL7,Q6PGP7,O75503,P35637,P13473,P14854,O15118,P01889,P27544,Q13510,O60313 Drugs and Diseases Human Phenotype Ontology msigdb_hp 0,400,268,19,275,22,26,280,28,30,414,413,292,38,43,45,175,185,60,190,445,447,66,325,322,73,203,205,341,338,82,86,87,213,342,343,353,488,477,358,480,104,235,237,363,109,369,501,250,375 1559,794,109,553,1142,375,2409,870,413,1056,104,342,477,1810,86,927,414,1443,28,369,73,30,3349,445,1877,205,275,268,1254,38,1358,2286,2597,981,2924,1189,676,213,237,363,983,43,1996,66,896,1415,1446,3127,2073,693,280,2859,343,1851,501,1747,322,2110,235,2149,2748,739,353,1395,447,1541,585,2001,2507,796,2967,557,2079,22,3310,2509,1612,1194,805,87,821,2387,3129,1195,2327,1014,512,3034,1783,1198,1450,807,741,3054,3295,203,292,3296,2609,2558,2418,1335,400,3071,250,338,60,1485,2750,2113,1398,2995,3185,1401,1262,2092,626,82,2786,480,1104,2610,2845,2393,1171,1128,933,1206,2680,1833,663,2729,2338,1176,1459,1209,1001,3158,358,937,2243,885,3387,1837,26,0,2518,1005,3231,850,325,3374,2208,2427,2209,185,341,1529,975,955,2543,708,3097,2066,2712,1216,190,19,488,2896,175,3043,1025,2741,1698,45 -0.02250118346835699,0.5076661391022604,2.1784605959005607,0.7896879996375533,0.22536929144369766,1.1657819605638418,-0.4464943548499513,0.43080383738421585,1.07084676596474,0.2894676887918951,2.189571052524327,1.2458108826688405,0.9321647887240839,-0.1424888753229872,2.321161071650228,0.3841256925736641,1.07084676596474,0.04479749007284595,3.0698107589013315,1.179204988513675,2.4178172840822203,3.0603364192521147,-1.7986048232476497,1.001966258000303,-0.1773059016141884,1.6777690135569574,1.4151493408700357,1.4279535786684734,0.1604504658814682,3.0127233121243298,0.09468784334280253,-0.373271876429598,-0.596278947334594,0.33701658189477507,-0.8699343008139493,0.19301386899346543,0.6431811538013191,1.641034754600386,1.554325783520826,1.1925938145223307,0.33701658189477507,2.9065277890482055,-0.22999085661134913,2.4918352621956807,0.41529180787632924,0.06148252180205109,0.04479749007284595,-1.096295452188383,-0.26542599868242417,0.6282990804246098,1.402314093228658,-0.8099892376198776,1.2458108826688405,-0.15986707294579158,0.8898304908049921,-0.10791253841717666,1.2853737321434007,-0.2832385860448953,1.5667994320520733,-0.30111518243997987,-0.7116898323792509,0.5833929390939195,1.2192696206606266,0.07811250742307049,1.001966258000303,-0.005591913085313469,0.7461703883999292,-0.22999085661134913,-0.5208177336190014,0.5076661391022604,-0.9103121062691136,0.7896879996375533,-0.26542599868242417,3.191546309151074,-1.5605037593216007,-0.5208177336190014,-0.03946755021715677,0.19301386899346543,0.4923857069491886,2.321161071650228,0.47705956297724367,-0.4280869276823581,-1.096295452188383,0.19301386899346543,-0.3914762369552328,0.32121625895525563,0.8756421363992508,-0.971515740451046,-0.12517084870498654,0.19301386899346543,0.04479749007284595,0.4923857069491886,0.5833929390939195,-0.992089953515064,-1.5142922206614813,1.7021191193583658,1.3765499068522848,-1.5142922206614813,-0.596278947334594,-0.558403728184664,-0.4464943548499513,0.11120892157867891,1.1117439633053623,-1.0127520150653435,1.5041368739934033,1.2590315225380515,2.5336885717746562,0.02805701137235168,-0.7116898323792509,-0.2832385860448953,0.07811250742307049,-0.9306276139125141,-1.1813127889529935,0.07811250742307049,0.1604504658814682,-0.26542599868242417,0.7022834886797121,2.342788021416518,-0.7311921139115007,0.9321647887240839,0.25751962221115077,-0.596278947334594,-0.7901703605422196,-0.4280869276823581,0.20921739577808898,0.24146991514915547,0.3841256925736641,0.19301386899346543,-0.6536448751928122,-0.1424888753229872,0.65802036299361,-0.6922649775615227,-0.3914762369552328,0.20921739577808898,0.04479749007284595,0.19301386899346543,0.33701658189477507,-1.1386163266404463,1.2192696206606266,0.3841256925736641,-0.33706243340680064,0.43080383738421585,-2.1012974711813244,-0.1424888753229872,3.107549151128594,3.937153403770652,-0.5208177336190014,0.33701658189477507,-1.289746149293953,0.4616874064468927,1.2853737321434007,-1.9727749634114744,-0.31905629408571334,-0.4464943548499513,-0.31905629408571334,1.774512395985724,1.2590315225380515,0.01126068031324202,0.3527680424371989,0.36847097049977656,-0.5395748804972572,0.6282990804246098,-1.0335027512907717,-0.24767692023999524,-0.6729168790091554,0.19301386899346543,1.7625145060761207,3.2192694624153164,0.9321647887240839,-0.8298890333091614,1.8103460646896083,-0.971515740451046,0.32121625895525563,-0.6922649775615227,-0.07357327446040215,2.7982738550861823 3430 transporter 25 56 4.318028340484641 1.574292196937499e-05 P53985,O60830,Q567V2,Q7Z3B4,Q99567,Q9Y619,Q9H2V7,Q9H2D1,O43681,Q15070,O43615,O60684,O15397,Q99595,Q92973,Q9C0E2,Q9Y584,O43772,Q9HD45,Q8N1F7,Q9HAV4,Q12769,P52294,Q92544,Q9NR77 Functions Panther Protein class panther_protein_class 271,20,151,559,42,45,46,49,553,181,565,198,328,78,208,602,119,468,90,611,614,478,117,247,123 1248,1908,1116,2347,2348,2215,328,565,553,468,198,20,979,1251,657,1572,1914,1915,966,117,1033,1100,271,1856,1418,1195,1014,478,1372,181,151,3386,559,611,627,1267,970,247,208,2424,42,78,1552,3314,602,49,46,614,90,123,1385,3022,1530,119,2815,45 0.1604504658814682,-0.1948058268211105,0.24146991514915547,-0.40974773902190176,-0.40974773902190176,-0.33706243340680064,1.2722190787348595,0.7752227411673067,0.7896879996375533,0.9462000577616902,1.7263589960332117,3.2100435371001237,0.33701658189477507,0.1604504658814682,0.65802036299361,-0.02250118346835699,-0.1948058268211105,-0.1948058268211105,0.3527680424371989,2.1113172784145564,0.30536674022651894,0.25751962221115077,1.4279535786684734,-0.15986707294579158,0.06148252180205109,0.19301386899346543,0.32121625895525563,0.9321647887240839,0.09468784334280253,1.7864835322979642,1.8930410423267858,-2.1012974711813244,0.7896879996375533,0.7169539114401163,0.7022834886797121,0.1604504658814682,0.3527680424371989,1.5167285531774126,1.6777690135569574,-0.4464943548499513,2.916265686588943,2.3750691920218543,-0.005591913085313469,-1.5605037593216007,0.7315827923762055,2.7383268943293446,2.7583811399319984,0.7169539114401163,2.2994483251380298,2.077431989617715,0.09468784334280253,-0.9510285615071858,0.01126068031324202,2.1113172784145564,-0.7507725016906376,2.7982738550861823 3430 Sphingolipid metabolic process 18 28 4.317123674310834 1.5807559760716572e-05 Q06136,O15269,P17900,P07602,Q9P035,O15270,P16278,Q9NZJ7,P06865,O60512,P06280,P50897,O95470,Q13510,Q8NCC3,P22059,Q96G23,P04062 Processes and pathways GO Biological process msigdb_gobp 258,286,66,38,294,295,43,341,268,18,275,22,86,250,91,316,124,30 286,295,18,86,30,275,268,38,1358,43,66,316,501,795,22,2511,258,988,250,951,91,124,340,591,641,341,294,1734 1.3894476706931538,1.3636206339195902,3.237676205824806,2.321161071650228,3.0603364192521147,1.4151493408700357,1.4279535786684734,3.0127233121243298,0.09468784334280253,2.9065277890482055,2.4918352621956807,1.2984956621256847,0.8898304908049921,0.5076661391022604,3.191546309151074,-0.5208177336190014,1.4661818634308703,0.33701658189477507,1.5041368739934033,0.36847097049977656,2.277649032464161,2.066089721766653,1.2590315225380515,0.7461703883999292,0.6875712647067221,1.2590315225380515,1.3765499068522848,-0.0907134950668146 3430 Lipid localization 30 80 4.312129552517813 1.61689642084184e-05 Q9BQE5,P30536,O14678,P61916,Q9NP80,P04083,Q99720,Q14849,P04062,P23786,P08183,Q4KMQ2,P07602,O14975,Q8WTV0,Q96SU4,Q9H2V7,P28288,Q14108,P22059,Q96GC9,P17900,O43808,Q9BZF1,Q9NZJ7,O43772,O15260,O15118,Q14534,P35610 Processes and pathways GO Biological process msigdb_gobp 0,2,257,512,264,148,26,27,30,33,159,163,38,424,169,564,46,555,60,316,188,66,573,458,341,468,98,109,122,252 856,3427,2796,257,424,109,98,468,573,2219,2693,1605,1144,3151,2224,30,148,1221,1952,38,1358,2286,159,676,1223,66,316,2261,33,555,841,2,1318,252,1914,1058,512,2607,2648,2511,2556,1578,60,122,27,163,953,812,2193,1722,730,902,3355,169,3000,188,564,26,0,2830,613,1591,1553,458,1942,3380,46,2520,264,1504,341,1734,1804,2135,1068,1530,2660,1845,1771,3176 0.44626893355334946,-4.650483787176411,-0.7507725016906376,1.4661818634308703,1.04340337414266,2.1784605959005607,2.2227671511588163,0.9462000577616902,0.7607169539788241,-0.33706243340680064,-0.6729168790091554,-0.03946755021715677,0.22536929144369766,-1.1386163266404463,-0.33706243340680064,3.0603364192521147,1.904751655596212,0.17675834803240076,-0.2123673195994045,3.0127233121243298,0.09468784334280253,-0.373271876429598,1.8695432160167267,0.6431811538013191,0.17675834803240076,2.4918352621956807,1.2984956621256847,-0.35513411913799386,3.0318170762153325,0.7896879996375533,0.4616874064468927,3.92901774642917,0.1276761298241045,1.4915153034770001,-0.1948058268211105,0.2894676887918951,0.8756421363992508,-0.596278947334594,-0.6344483133432426,-0.5208177336190014,-0.558403728184664,-0.02250118346835699,2.5336885717746562,2.077431989617715,3.0792691433168833,1.8577557582221775,0.36847097049977656,0.4923857069491886,-0.31905629408571334,-0.0907134950668146,0.5984052493734849,0.41529180787632924,-1.8230922651443087,1.8459424393187207,-0.9306276139125141,1.7625145060761207,0.7896879996375533,3.107549151128594,3.937153403770652,-0.7704316844994457,0.7169539114401163,-0.02250118346835699,-0.005591913085313469,0.9741576934609325,-0.1948058268211105,-2.049460345691425,2.7583811399319984,-0.5208177336190014,1.4534696782308594,0.02805701137235168,1.2590315225380515,-0.0907134950668146,-0.12517084870498654,-0.2832385860448953,0.2894676887918951,0.01126068031324202,-0.6344483133432426,-0.1424888753229872,-0.10791253841717666,-1.1599171531024435 3430 Mitochondrial protein containing complex 62 159 4.292116407222438 1.7697811957928522e-05 Q99623,Q14197,P51970,P11177,Q9NS69,P21796,P24539,Q96CU9,O95168,O60830,O43676,Q9Y512,Q567V2,O14949,P00403,Q9P0J0,O75306,P12236,Q86Y39,P06576,O75438,P08574,Q9H2W6,O75964,P82933,Q9Y5J7,Q13505,P21912,Q6UXV4,Q9BRJ2,P14406,Q9Y5J9,Q9Y6M9,Q9BYC9,Q9NQ50,P03886,Q9UDW1,Q15118,O14925,Q99595,Q9NP92,P13073,Q9NX63,P12235,P56385,P09001,Q8IYU8,Q9NVH1,Q9NVS2,Q9BUR5,Q8N4H5,O96000,Q16891,P21953,P05141,P14854,Q5XKP0,Q9Y584,Q7Z7H8,O00411,O76031,Q9Y5L4 Localization GO Cellular component msigdb_gocc 517,513,386,509,7,9,138,274,529,20,21,278,151,155,28,158,413,418,168,674,671,296,428,47,177,571,58,693,697,451,64,193,326,721,459,73,74,329,204,78,603,336,732,213,726,723,347,616,486,613,101,606,479,737,736,363,626,119,505,249,251,125 892,1948,249,1950,799,204,155,21,2922,961,20,1441,413,978,1010,671,1442,3081,47,251,1098,529,3008,2033,606,1443,28,73,736,674,2035,296,723,1568,1392,2924,840,509,1222,213,418,336,64,363,3331,2770,2639,1119,9,693,737,984,138,2925,3031,2598,1747,784,1781,1257,3050,948,1075,3379,2481,3152,2991,2041,1060,386,2669,2483,2510,2080,726,1034,1576,1332,2085,930,1333,177,988,1370,58,513,329,900,3131,1673,479,968,951,151,811,626,1928,697,1424,2159,505,168,756,1173,347,101,3154,1130,2565,2012,1978,274,2538,3157,972,3404,78,517,1837,451,613,721,2244,1178,973,3285,1243,428,1660,1867,1006,1943,603,459,1594,7,616,486,2541,2813,732,1159,865,158,74,1350,943,2316,1280,2523,2984,1531,1025,278,119,571,193,125,326 0.41529180787632924,-0.2123673195994045,1.5041368739934033,-0.2123673195994045,0.4923857069491886,1.6777690135569574,1.8813049364421908,3.200802504118346,-0.8699343008139493,0.3527680424371989,3.2100435371001237,0.04479749007284595,1.07084676596474,0.33701658189477507,0.32121625895525563,0.6431811538013191,0.04479749007284595,-1.0335027512907717,2.748363067010926,1.4915153034770001,0.25751962221115077,0.8471486580863727,-0.9510285615071858,-0.24767692023999524,0.7169539114401163,0.04479749007284595,3.0698107589013315,2.4178172840822203,0.5833929390939195,0.6431811538013191,-0.24767692023999524,1.3636206339195902,0.5984052493734849,-0.02250118346835699,0.07811250742307049,-0.8699343008139493,0.4616874064468927,0.8756421363992508,0.17675834803240076,1.641034754600386,1.057143066123191,1.2590315225380515,2.5128016570172145,1.1925938145223307,-1.6780491319681583,-0.7311921139115007,-0.6344483133432426,0.24146991514915547,3.489279818123242,0.6282990804246098,0.5833929390939195,0.33701658189477507,1.9744867066455778,-0.8699343008139493,-0.971515740451046,-0.596278947334594,-0.10791253841717666,0.522901157152449,-0.12517084870498654,0.1604504658814682,-0.992089953515064,0.36847097049977656,0.2735187641595761,-2.0237575733036444,-0.5021316919187672,-1.1386163266404463,-0.9306276139125141,-0.24767692023999524,0.2894676887918951,1.1388325289942267,-0.6536448751928122,-0.5021316919187672,-0.5208177336190014,-0.26542599868242417,0.5984052493734849,0.30536674022651894,-0.02250118346835699,0.11120892157867891,-0.26542599868242417,0.3841256925736641,0.11120892157867891,1.798428045397234,0.33701658189477507,0.09468784334280253,2.5544966637542177,0.8756421363992508,1.2722190787348595,0.41529180787632924,-1.096295452188383,-0.07357327446040215,0.9321647887240839,0.3527680424371989,0.36847097049977656,1.8930410423267858,0.4923857069491886,0.7022834886797121,-0.1948058268211105,0.6282990804246098,0.06148252180205109,-0.30111518243997987,0.8898304908049921,1.8459424393187207,0.5683366593475094,0.20921739577808898,1.2458108826688405,2.211724229893288,-1.1386163266404463,0.24146991514915547,-0.558403728184664,-0.22999085661134913,-0.2123673195994045,1.4279535786684734,-0.5395748804972572,-1.1386163266404463,0.3527680424371989,-2.4814738005103227,2.3750691920218543,0.8756421363992508,-0.1424888753229872,1.001966258000303,0.7169539114401163,0.6133738705970863,-0.33706243340680064,0.20921739577808898,0.3527680424371989,-1.468526945815869,0.17675834803240076,1.04340337414266,-0.0564914375226667,-0.15986707294579158,0.33701658189477507,-0.1948058268211105,0.7315827923762055,0.9741576934609325,-0.02250118346835699,3.602417135580486,0.7169539114401163,0.9321647887240839,-0.5395748804972572,-0.7507725016906376,0.5984052493734849,0.22536929144369766,0.44626893355334946,1.8813049364421908,2.4178172840822203,0.11120892157867891,0.3841256925736641,-0.373271876429598,0.1604504658814682,-0.5208177336190014,-0.9103121062691136,0.01126068031324202,0.32121625895525563,1.4151493408700357,2.1113172784145564,0.7752227411673067,1.750489731196436,2.066089721766653,1.2853737321434007 3430 Inner mitochondrial membrane protein complex 38 76 4.276496103666513 1.898578782610905e-05 Q99623,P51970,P24539,Q96CU9,O95168,O60830,O43676,Q9Y512,O14949,P00403,Q9P0J0,O75306,P12236,Q86Y39,P08574,O75438,P06576,O75964,Q9Y5J7,Q13505,P21912,Q6UXV4,P14406,Q9Y6M9,P03886,Q9UDW1,O14925,Q99595,P13073,Q9NX63,Q8IYU8,Q9NVH1,Q9BUR5,O96000,Q16891,P14854,Q5XKP0,Q9Y584 Localization GO Cellular component msigdb_gocc 517,386,138,274,529,20,21,278,155,28,158,413,418,168,296,671,674,47,571,58,693,697,64,326,73,74,204,78,336,732,347,616,613,606,479,363,626,119 892,1950,204,155,21,2922,20,1441,413,978,1010,671,1442,3081,47,529,3008,2033,606,28,73,674,296,1392,840,418,336,64,363,3331,2770,2639,1119,693,984,138,2925,3031,1747,784,1781,1257,3050,1075,3379,3152,386,2080,726,58,3131,1673,479,968,951,626,697,168,347,1130,274,972,78,517,613,1867,616,732,158,74,1350,1025,278,119,571,326 0.41529180787632924,-0.2123673195994045,1.6777690135569574,1.8813049364421908,3.200802504118346,-0.8699343008139493,3.2100435371001237,0.04479749007284595,1.07084676596474,0.33701658189477507,0.32121625895525563,0.6431811538013191,0.04479749007284595,-1.0335027512907717,2.748363067010926,0.8471486580863727,-0.9510285615071858,-0.24767692023999524,0.7169539114401163,3.0698107589013315,2.4178172840822203,0.6431811538013191,1.3636206339195902,0.07811250742307049,0.4616874064468927,1.057143066123191,1.2590315225380515,2.5128016570172145,1.1925938145223307,-1.6780491319681583,-0.7311921139115007,-0.6344483133432426,0.24146991514915547,0.6282990804246098,0.33701658189477507,1.9744867066455778,-0.8699343008139493,-0.971515740451046,-0.10791253841717666,0.522901157152449,-0.12517084870498654,0.1604504658814682,-0.992089953515064,0.2735187641595761,-2.0237575733036444,-1.1386163266404463,1.1388325289942267,-0.26542599868242417,0.5984052493734849,2.5544966637542177,-1.096295452188383,-0.07357327446040215,0.9321647887240839,0.3527680424371989,0.36847097049977656,0.7022834886797121,0.6282990804246098,1.8459424393187207,1.2458108826688405,0.24146991514915547,1.4279535786684734,0.3527680424371989,2.3750691920218543,0.8756421363992508,0.7169539114401163,-0.15986707294579158,0.7169539114401163,0.5984052493734849,1.8813049364421908,2.4178172840822203,0.11120892157867891,0.32121625895525563,1.4151493408700357,2.1113172784145564,0.7752227411673067,1.2853737321434007 3430 Organic acid transport 22 46 4.276004080506537 1.902777366802333e-05 O14678,Q9NP80,Q9UBX3,P53985,P30825,P04083,Q96NB2,Q9BQT8,P08183,P23786,P11166,O14975,Q9Y619,Q9H2D1,P28288,Q9UJS0,O75746,Q02978,P55011,O43808,O43772,Q6P4A7 Processes and pathways GO Biological process msigdb_gobp 257,264,13,271,402,148,410,157,159,33,676,424,45,49,555,708,692,696,574,573,468,232 257,424,468,573,2408,692,1507,839,1144,2224,148,1607,2286,159,1567,676,1223,2073,33,555,841,402,1318,1058,1100,271,574,1918,2648,696,713,1488,950,2193,232,996,410,157,49,1409,942,264,13,708,2660,45 1.4661818634308703,1.04340337414266,0.9462000577616902,0.7607169539788241,-0.4464943548499513,0.6282990804246098,0.01126068031324202,0.4616874064468927,0.22536929144369766,-0.33706243340680064,1.904751655596212,-0.03946755021715677,-0.373271876429598,1.8695432160167267,-0.02250118346835699,0.6431811538013191,0.17675834803240076,-0.26542599868242417,3.0318170762153325,0.7896879996375533,0.4616874064468927,1.0981470112960925,0.1276761298241045,0.2894676887918951,0.25751962221115077,1.4279535786684734,0.7607169539788241,-0.1948058268211105,-0.6344483133432426,0.6282990804246098,0.6133738705970863,0.02805701137235168,0.36847097049977656,-0.31905629408571334,1.5792439505261,0.33701658189477507,1.0845146796370766,1.8813049364421908,2.7383268943293446,0.07811250742307049,0.3841256925736641,1.4534696782308594,3.391761695054266,0.6282990804246098,-0.6344483133432426,2.7982738550861823 3430 Mitochondria 137 426 4.239712803440796 2.238059391124203e-05 Q99623,Q14197,P52789,P11177,Q9NS69,P48735,Q69YU5,Q9UBX3,Q7KZN9,P45880,Q70HW3,O95168,Q9Y2R0,O60830,P23786,Q9UDX5,Q96EX1,O75964,Q9H2D1,P43304,Q9Y2S7,Q9Y5J7,Q13505,O43615,Q6NUK1,Q9H2U1,Q3SXM5,Q9H4I3,P00374,Q9NWU1,Q99595,Q6DKK2,Q5JRX3,Q9NVH1,Q96A26,Q9BUR5,Q8N4H5,Q8WY22,Q5XKP0,Q07820,Q16836,Q9Y5L4,Q7LGA3,Q8NAN2,Q5JPH6,P36551,P24539,Q9Y6C9,Q13423,O14949,Q9P0J0,Q9H9P8,Q8TAE8,P53701,Q86Y39,P06576,O75438,P00367,Q9BXK5,P82933,Q9UJS0,Q15070,Q9NWS8,Q9NR28,P21912,Q6UXV4,O43292,P82663,Q9NVH6,Q9BYC9,Q96C01,O14925,Q68CZ6,Q9NX40,Q9NX63,Q00325,P12235,Q9NSK0,P56385,Q9NUJ1,Q9P032,Q6P4A7,Q07021,P21953,P57105,P05141,Q9UHQ9,Q8IWA4,Q96CX2,O00411,O76031,Q9Y394,Q4VC31,Q5T9A4,Q96CU9,Q9Y512,Q99797,Q10713,Q8N6Q8,P08574,Q9Y277,P13674,Q14168,Q9Y6M9,Q9NPL8,P13073,O95302,Q8IYU8,Q9BYT8,Q96AY3,Q9NUQ2,P14854,Q8N3Z3,O60313,P51970,Q15120,Q8TB36,O14734,Q9NZ45,O95202,Q96NB2,Q7Z4V5,O95831,O75306,P12236,Q9H2W6,Q96EY8,Q9NVI7,O75648,Q9NQ50,Q9H7Z7,O43772,P23378,Q16891,Q9NQG6,Q7Z7H8,Q9NUT2 Localization Protein Atlas Subcellular protein_atlas_subcellular_location_all 517,513,510,509,7,10,11,13,525,15,16,529,19,20,33,41,562,47,49,556,570,571,58,565,580,583,67,70,76,590,78,82,85,616,96,613,101,114,626,621,625,125,128,134,651,647,138,145,146,155,158,688,683,167,168,674,671,673,174,177,708,181,182,705,693,697,194,695,197,721,718,204,714,212,732,214,213,731,726,221,749,232,742,737,238,736,760,756,757,249,251,768,765,259,274,278,290,292,293,296,309,314,315,326,325,336,333,347,349,357,367,363,378,375,386,389,390,391,405,401,410,415,414,413,418,428,442,443,444,459,474,468,471,479,499,505,519 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3430 Receptor 19 42 4.194526295658827 2.734424305383953e-05 Q99623,P24390,Q9NS69,O14786,O00264,P35613,P30825,Q99720,Q8WTV0,Q14108,Q99523,Q14739,O43731,O15173,P78310,Q9Y2I1,P55899,Q9Y5M8,O15118 Functions Protein Atlas Molecular function protein_atlas_molecular_function 517,6,7,520,143,270,402,26,169,60,600,222,97,99,608,633,111,236,109 143,520,945,109,99,97,1314,1607,1608,1221,1508,3272,2147,873,646,1509,1995,2148,1147,2457,6,402,270,111,608,2364,1578,60,222,950,169,1656,882,600,517,26,2890,7,2497,633,957,236 1.9513415899455118,0.861414936766202,0.36847097049977656,2.1784605959005607,2.211724229893288,2.233787760016152,0.1276761298241045,-0.03946755021715677,-0.03946755021715677,0.17675834803240076,0.01126068031324202,-1.445808727840182,-0.30111518243997987,0.43080383738421585,0.6728169776242082,0.01126068031324202,-0.22999085661134913,-0.30111518243997987,0.22536929144369766,-0.4835161673691688,3.713359366894026,1.0981470112960925,1.4279535786684734,2.1784605959005607,0.7169539114401163,-0.40974773902190176,-0.02250118346835699,2.5336885717746562,1.6164042064007391,0.36847097049977656,1.8459424393187207,-0.0564914375226667,0.43080383738421585,0.7315827923762055,0.8756421363992508,3.107549151128594,-0.8298890333091614,3.602417135580486,-0.5021316919187672,0.7022834886797121,0.36847097049977656,1.5667994320520733 3430 Cation transmembrane transporter activity 31 65 4.193166792353779 2.750870274170758e-05 P20020,P24539,Q7KZN9,P16615,Q70HW3,Q13423,P30825,O95202,Q9H0U3,Q96NB2,Q9Y6M7,P00403,Q4KMQ2,Q9HD20,Q96ES6,P08574,Q9Y619,Q9Y487,O75964,Q15043,P55011,O43808,Q9UDW1,P13073,Q9BXP2,Q00325,P12235,O43772,Q6P4Q7,Q93050,P14854 Functions GO Molecular function msigdb_gomf 385,138,525,269,16,146,402,401,536,410,548,28,163,35,37,296,45,175,47,191,574,573,74,336,601,214,213,468,598,220,363 468,573,3081,47,401,28,607,736,674,1221,1952,2146,1567,296,840,213,336,363,269,385,1119,3191,3343,819,138,2925,402,784,1257,2149,2748,1075,3379,574,2080,726,1259,1014,214,2464,146,191,950,163,598,16,525,1130,882,220,37,410,1552,601,536,1409,942,35,74,2136,668,175,2067,45,548 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3430 Outer membrane 35 93 4.188399356602242 2.8092884452934896e-05 Q99623,P30536,P52789,Q8TB36,Q9NS69,Q8NAN2,P21796,O43169,P45880,O00264,Q9Y6C9,Q9NZ45,Q9Y512,Q99720,Q8N2A8,P50402,Q9Y277,Q13505,P09601,Q9NXE4,Q9NZJ7,Q6NUM9,Q9NVH1,Q9BUR5,P42345,Q8N4H5,Q96RL7,Q16891,Q9NUQ2,Q9UBM7,P57105,Q8WY22,Q9NQG6,Q5XKP0,O60313 Localization GO Cellular component msigdb_gocc 517,2,510,390,7,134,9,14,15,143,145,405,278,26,164,431,309,58,59,591,341,216,616,613,353,101,358,479,367,632,238,114,499,626,375 143,1559,3427,14,375,1161,2031,1010,1098,1144,1443,1876,858,3216,1878,59,1880,9,2,1318,2718,3050,353,1395,15,431,1058,510,2510,238,2267,988,621,2609,58,1821,900,3016,479,951,2581,626,216,2957,697,2393,1827,756,1521,997,933,164,101,1206,134,1040,390,1043,114,1324,1133,2516,1726,358,1658,1938,517,26,1212,613,2961,887,2128,1940,890,1326,499,2342,7,367,1112,616,2023,732,591,405,341,632,3398,309,3222,278,145 1.9513415899455118,-0.02250118346835699,-4.650483787176411,3.3468758304359083,1.1657819605638418,0.20921739577808898,-0.24767692023999524,0.32121625895525563,0.25751962221115077,0.22536929144369766,0.04479749007284595,-0.1773059016141884,0.44626893355334946,-1.267862233870033,-0.1773059016141884,2.54410242985927,-0.1773059016141884,3.489279818123242,3.92901774642917,0.1276761298241045,-0.6922649775615227,-0.992089953515064,1.2192696206606266,0.07811250742307049,3.2925394092933984,1.0296274822176772,0.2894676887918951,0.8756421363992508,-0.5208177336190014,1.554325783520826,-0.35513411913799386,0.33701658189477507,0.7022834886797121,-0.596278947334594,2.5544966637542177,-0.1424888753229872,0.41529180787632924,-0.9510285615071858,0.9321647887240839,0.36847097049977656,-0.5773048800496771,0.7022834886797121,1.641034754600386,-0.8900812583352817,0.6282990804246098,-0.4280869276823581,-0.1424888753229872,0.5683366593475094,0.01126068031324202,0.33701658189477507,0.3841256925736641,1.8577557582221775,2.211724229893288,0.19301386899346543,2.0090196896501236,0.30536674022651894,1.1388325289942267,0.30536674022651894,2.167327425815136,0.1276761298241045,0.24146991514915547,-0.5208177336190014,-0.0907134950668146,1.2192696206606266,-0.0564914375226667,-0.1948058268211105,0.8756421363992508,3.107549151128594,0.19301386899346543,0.7169539114401163,-0.8900812583352817,0.43080383738421585,-0.2832385860448953,-0.1948058268211105,0.43080383738421585,0.1276761298241045,0.903980231650309,-0.3914762369552328,3.602417135580486,1.1925938145223307,0.25751962221115077,0.7169539114401163,-0.22999085661134913,0.5984052493734849,0.7461703883999292,1.0981470112960925,1.2590315225380515,0.7022834886797121,-2.2874512966961964,1.3376668826640072,-1.267862233870033,1.4151493408700357,1.9397317456196084 3430 Secondary alcohol metabolic process 17 46 4.178061269188547 2.9400446481586684e-05 Q9BQE5,O75874,P37268,P16435,Q8WTV0,P48735,P54646,P05067,O15118,Q06520,Q16850,Q15392,Q15800,Q14534,Q14849,Q14739,P04062 Processes and pathways GO Biological process msigdb_gobp 0,1,166,231,169,10,75,205,109,144,210,23,88,122,27,222,30 109,961,566,470,1,382,2070,1876,30,205,3301,2697,231,1997,928,252,166,2776,753,10,1258,2991,1060,1855,3383,75,2081,512,2607,3312,144,3254,122,222,27,3220,23,1169,88,210,169,3001,0,1553,632,2135 2.1784605959005607,0.3527680424371989,0.7752227411673067,0.9462000577616902,3.92901774642917,1.1523245386286525,-0.26542599868242417,-0.1773059016141884,3.0603364192521147,1.6777690135569574,-1.5373416114687155,-0.6729168790091554,1.5792439505261,-0.22999085661134913,0.3841256925736641,1.4915153034770001,1.8459424393187207,-0.7311921139115007,0.5683366593475094,3.454011813127605,0.1604504658814682,-0.9306276139125141,0.2894676887918951,-0.15986707294579158,-2.0753063910430853,2.4071614359087854,-0.26542599868242417,0.8756421363992508,-0.596278947334594,-1.5605037593216007,1.9513415899455118,-1.3560056220962575,2.077431989617715,1.6164042064007391,3.0792691433168833,-1.267862233870033,3.1543688124281597,0.20921739577808898,2.310315469590055,1.6655522802639968,1.8459424393187207,-0.9306276139125141,3.937153403770652,-0.005591913085313469,0.7022834886797121,-0.2832385860448953 3430 Mental deterioration 34 100 4.164688220613184 3.117783272266195e-05 Q9BQE5,P06865,P50897,P21964,P00403,P04062,O75306,Q10713,P07602,P16278,Q9Y487,Q9Y287,Q14108,P04350,P42858,P17900,Q9NPL8,P31483,P03886,Q06787,P05067,Q9NZJ7,O95470,P54802,P22626,O76024,Q96RL7,O75503,P35637,P14854,O15118,P27544,Q13510,O60313 Drugs and Diseases Human Phenotype Ontology msigdb_hp 0,268,22,280,28,30,413,292,38,43,175,190,60,445,447,66,325,322,73,203,205,341,86,87,343,477,358,104,235,363,109,501,250,375 1559,109,553,1142,375,2409,870,413,104,477,1810,86,1443,28,73,30,3349,445,205,268,38,1358,2597,981,2924,1189,363,983,43,1996,66,896,1446,693,280,343,1851,501,1747,322,235,2149,2748,1395,447,1541,585,2967,22,3310,2509,87,821,2387,512,3034,1783,807,741,3054,3295,203,292,2609,2418,250,60,1485,2995,1262,626,2786,1104,2610,2393,1171,1128,1206,2680,663,2729,2338,1209,3158,358,937,3387,1837,0,2518,3231,325,2209,341,1529,975,3097,190,175,3043 -0.02250118346835699,2.1784605959005607,0.7896879996375533,0.22536929144369766,1.1657819605638418,-0.4464943548499513,0.43080383738421585,1.07084676596474,2.189571052524327,0.9321647887240839,-0.1424888753229872,2.321161071650228,0.04479749007284595,3.0698107589013315,2.4178172840822203,3.0603364192521147,-1.7986048232476497,1.001966258000303,1.6777690135569574,1.4279535786684734,3.0127233121243298,0.09468784334280253,-0.596278947334594,0.33701658189477507,-0.8699343008139493,0.19301386899346543,1.1925938145223307,0.33701658189477507,2.9065277890482055,-0.22999085661134913,2.4918352621956807,0.41529180787632924,0.04479749007284595,0.6282990804246098,1.402314093228658,1.2458108826688405,-0.15986707294579158,0.8898304908049921,-0.10791253841717666,1.2853737321434007,1.5667994320520733,-0.30111518243997987,-0.7116898323792509,0.07811250742307049,1.001966258000303,-0.005591913085313469,0.7461703883999292,-0.9103121062691136,3.191546309151074,-1.5605037593216007,-0.5208177336190014,2.321161071650228,0.47705956297724367,-0.4280869276823581,0.8756421363992508,-0.971515740451046,-0.12517084870498654,0.4923857069491886,0.5833929390939195,-0.992089953515064,-1.5142922206614813,1.7021191193583658,1.3765499068522848,-0.596278947334594,-0.4464943548499513,1.5041368739934033,2.5336885717746562,0.02805701137235168,-0.9306276139125141,0.1604504658814682,0.7022834886797121,-0.7311921139115007,0.25751962221115077,-0.596278947334594,-0.4280869276823581,0.20921739577808898,0.24146991514915547,0.19301386899346543,-0.6536448751928122,0.65802036299361,-0.6922649775615227,-0.3914762369552328,0.19301386899346543,-1.1386163266404463,1.2192696206606266,0.3841256925736641,-2.1012974711813244,-0.1424888753229872,3.937153403770652,-0.5208177336190014,-1.289746149293953,1.2853737321434007,-0.31905629408571334,1.2590315225380515,0.01126068031324202,0.3527680424371989,-1.0335027512907717,1.7625145060761207,1.8103460646896083,-0.971515740451046 3430 Metabolism of lipids 76 200 4.146631303911766 3.374027218749909e-05 P30536,Q06136,O76062,Q53GQ0,Q8NAN2,Q9NP80,P38435,Q15165,O14734,O00767,Q8WVX9,Q06520,P06865,P06280,P50897,Q15392,Q96K12,Q14849,O15254,P04062,P23786,O15269,Q8N2A8,Q10713,P07602,P37268,Q9P035,O14975,Q96SU4,P16278,O15270,Q9BWD1,P43304,O95864,O43681,O15228,Q96N66,P22059,Q15067,Q6IAN0,P17900,O43808,Q9BZF1,Q709F0,P54646,Q9BTU6,Q9NXE4,Q9NZJ7,Q99519,Q16850,O75845,O95470,Q9H7Z7,Q15800,O43772,Q8NCC3,Q9NPH0,Q14739,A8MXV4,Q9UG56,P10619,Q14534,P48651,Q13510,Q9NUQ2,P51648,Q9UBM7,Q8NF37,Q8TBX8,P27544,Q8IV08,O95487,Q16836,P35610,Q96G23,Q9NZ01 Processes and pathways Reactome Pathways msigdb_reactome 2,258,382,262,134,264,136,139,391,644,663,144,268,275,22,23,283,27,285,30,33,286,164,292,38,166,294,424,564,43,295,304,556,554,553,307,189,316,319,579,66,573,458,457,75,587,591,341,340,210,470,86,474,88,468,91,94,222,350,487,226,122,360,250,367,110,632,506,242,501,120,618,625,252,124,641 856,350,1184,2986,1389,1437,3427,644,391,424,307,285,286,295,3322,553,468,573,2030,1161,2219,2455,2144,655,2381,470,382,2897,1993,86,1605,618,1144,554,3151,30,3421,1606,275,268,38,1358,3287,2480,226,3358,2697,3141,983,3408,43,2109,3303,66,2260,1361,1665,316,2261,1997,33,2354,501,3011,2,1318,928,252,2926,2718,166,136,948,740,929,1961,2776,556,2359,753,360,1914,796,1258,1058,22,110,1194,1100,1855,3383,2670,75,2510,3182,2081,2186,2604,1751,2992,2416,1366,2044,2648,3312,1450,258,144,1968,292,3423,1035,250,2234,3254,122,222,27,3413,1372,319,3220,139,1016,23,1126,2190,1169,88,625,210,2784,1401,262,951,1170,579,823,457,1205,120,1128,164,1863,3425,1457,134,1623,91,506,242,663,2729,2122,124,283,189,2203,1380,564,1937,340,1272,2887,1086,2830,587,1047,904,3403,304,1553,458,3380,474,1382,264,94,2373,1868,2342,851,367,1022,591,641,341,294,1734,632,487,1386,2660,1843,1024,957,2251,751,3176,2172 0.44626893355334946,1.2325569767034361,0.19301386899346543,-0.9306276139125141,0.07811250742307049,0.04479749007284595,-4.650483787176411,0.6728169776242082,1.125305736257329,1.04340337414266,1.3376668826640072,1.3894476706931538,1.3894476706931538,1.3636206339195902,-1.6306790060749776,0.7896879996375533,0.9462000577616902,0.7607169539788241,-0.24767692023999524,0.20921739577808898,-0.33706243340680064,-0.4835161673691688,-0.30111518243997987,0.65802036299361,-0.4280869276823581,0.9462000577616902,1.1523245386286525,-0.8498704751461239,-0.22999085661134913,2.321161071650228,-0.03946755021715677,0.7022834886797121,0.22536929144369766,0.7896879996375533,-1.1386163266404463,3.0603364192521147,-3.7873509360750597,-0.03946755021715677,1.4151493408700357,1.4279535786684734,3.0127233121243298,0.09468784334280253,-1.4913543909405875,-0.5021316919187672,1.6040461907838122,-1.8477085071425041,-0.6729168790091554,-1.117409393747407,0.33701658189477507,-2.654620431576343,2.9065277890482055,-0.2832385860448953,-1.5373416114687155,2.4918352621956807,-0.35513411913799386,0.09468784334280253,-0.07357327446040215,1.2984956621256847,-0.35513411913799386,-0.22999085661134913,3.0318170762153325,-0.40974773902190176,0.8898304908049921,-0.9510285615071858,3.92901774642917,0.1276761298241045,0.3841256925736641,1.4915153034770001,-0.8699343008139493,-0.6922649775615227,1.8459424393187207,1.9975331678372859,0.36847097049977656,0.5833929390939195,0.3841256925736641,-0.2123673195994045,-0.7311921139115007,0.7896879996375533,-0.40974773902190176,0.5683366593475094,1.2059486289837344,-0.1948058268211105,0.5076661391022604,0.1604504658814682,0.2894676887918951,3.191546309151074,2.1784605959005607,0.19301386899346543,0.25751962221115077,-0.15986707294579158,-2.0753063910430853,-0.6536448751928122,2.4071614359087854,-0.5208177336190014,-1.1813127889529935,-0.26542599868242417,-0.31905629408571334,-0.596278947334594,-0.10791253841717666,-0.9306276139125141,-0.4464943548499513,0.09468784334280253,-0.24767692023999524,-0.6344483133432426,-1.5605037593216007,0.04479749007284595,1.4661818634308703,1.9513415899455118,-0.2123673195994045,1.3765499068522848,-4.100608375150396,0.30536674022651894,1.5041368739934033,-0.33706243340680064,-1.3560056220962575,2.077431989617715,1.6164042064007391,3.0792691433168833,-2.9274662311336455,0.09468784334280253,1.2984956621256847,-1.267862233870033,1.9744867066455778,0.32121625895525563,3.1543688124281597,0.24146991514915547,-0.31905629408571334,0.20921739577808898,2.310315469590055,0.7022834886797121,1.6655522802639968,-0.7311921139115007,0.07811250742307049,1.4534696782308594,0.36847097049977656,0.20921739577808898,0.7607169539788241,0.47705956297724367,0.9741576934609325,0.19301386899346543,2.1000456604552045,0.24146991514915547,1.8577557582221775,-0.15986707294579158,-4.348155832158833,0.04479749007284595,2.0090196896501236,-0.03946755021715677,2.277649032464161,0.8898304908049921,1.5418228550895896,0.65802036299361,-0.6922649775615227,-0.2832385860448953,2.066089721766653,1.402314093228658,1.7625145060761207,-0.31905629408571334,0.09468784334280253,0.7896879996375533,-0.1948058268211105,1.2590315225380515,0.1604504658814682,-0.8298890333091614,0.2735187641595761,-0.7704316844994457,0.7461703883999292,0.30536674022651894,0.41529180787632924,-2.453246656927495,1.3506596827179598,-0.005591913085313469,0.9741576934609325,-2.049460345691425,0.9462000577616902,0.09468784334280253,1.4534696782308594,2.2667166943530197,-0.40974773902190176,-0.15986707294579158,-0.3914762369552328,0.4616874064468927,1.1925938145223307,0.32121625895525563,0.7461703883999292,0.6875712647067221,1.2590315225380515,1.3765499068522848,-0.0907134950668146,0.7022834886797121,0.9321647887240839,0.09468784334280253,-0.6344483133432426,-0.1424888753229872,0.32121625895525563,0.36847097049977656,-0.33706243340680064,0.5833929390939195,-1.1599171531024435,-0.30111518243997987 3430 Golgi apparatus 53 183 4.121691384256651 3.761008299840718e-05 P80303,P24390,Q9NP80,Q9UBU6,Q8TBA6,Q92896,O60512,Q8IYR2,P50897,Q6P179,Q96K12,Q9NXU5,O00461,Q13190,Q16706,Q6ZRP7,Q9HB40,Q96SU4,P16278,Q8N4A0,P67812,Q9H2V7,Q9H8H2,Q9NWM8,A1L0T0,P09601,Q9Y287,P22059,Q15043,Q5VW38,Q6NUQ1,O15127,P54646,P05067,Q9BRK5,Q13535,Q8NBN3,O95302,Q9HD45,Q93050,Q8IZA0,Q9UG56,O15260,Q5BKZ1,O60476,Q9NPR9,Q14376,Q8N4Q0,O75071,P25398,P04439,Q02818,O60637 Localization Protein Atlas Subcellular protein_atlas_subcellular_location_all 5,6,264,265,272,273,18,404,22,407,283,537,31,541,551,552,40,564,43,172,173,46,178,179,54,59,190,316,191,68,452,72,75,205,81,338,464,333,90,220,93,487,98,355,227,107,489,492,112,495,244,246,126 54,906,2635,2026,868,31,1773,1353,1218,72,1635,818,98,2318,3322,2454,2617,3308,227,1161,18,126,2430,2409,2220,112,2257,2574,802,709,2285,333,1219,3151,244,205,1704,59,873,3162,1509,983,43,3142,316,6,495,3063,3065,2775,1031,1641,3226,1710,2835,3104,2290,910,2079,1192,1363,22,3310,805,1964,2953,1712,75,1749,2932,173,5,2484,1198,246,2511,3304,914,875,2557,541,1260,338,2295,1423,2881,489,989,1718,191,551,355,2841,2785,68,2842,812,2300,597,452,1234,407,1650,2977,552,2845,864,2116,825,2958,902,2160,2336,798,2009,404,93,791,172,492,1932,2728,464,2117,1020,272,639,1377,1082,273,882,220,560,2611,3246,283,1657,2733,564,600,2015,1727,1590,3267,81,1464,1591,3076,2206,2941,46,1659,3077,748,3424,178,2850,850,2736,40,90,2764,264,107,1384,2342,1502,851,1503,1631,179,537,265,487,3398,1068,2104,3278,1349,190,1991,944,1410 2.6267135515683826,0.3997325317718629,-0.6344483133432426,-0.24767692023999524,0.43080383738421585,3.050846065270086,-0.12517084870498654,0.09468784334280253,0.17675834803240076,2.4284524960951095,-0.0564914375226667,0.47705956297724367,2.2227671511588163,-0.3914762369552328,-1.6306790060749776,-0.4835161673691688,-0.6153265492951593,-1.5605037593216007,1.5916594876052144,0.20921739577808898,3.237676205824806,2.0547236877093185,-0.4649705794159142,-0.4464943548499513,-0.33706243340680064,2.167327425815136,-0.35513411913799386,-0.5773048800496771,0.4923857069491886,0.6133738705970863,-0.373271876429598,1.2590315225380515,0.17675834803240076,-1.1386163266404463,1.5292904957224467,1.6777690135569574,-0.0907134950668146,2.54410242985927,0.43080383738421585,-1.1599171531024435,0.01126068031324202,0.33701658189477507,2.9065277890482055,-1.117409393747407,1.2984956621256847,3.713359366894026,0.903980231650309,-1.0127520150653435,-1.0127520150653435,-0.7311921139115007,0.30536674022651894,-0.0564914375226667,-1.289746149293953,-0.0907134950668146,-0.7901703605422196,-1.0543430004362901,-0.373271876429598,0.3997325317718629,-0.26542599868242417,0.19301386899346543,0.09468784334280253,3.191546309151074,-1.5605037593216007,0.4923857069491886,-0.2123673195994045,-0.8900812583352817,-0.0907134950668146,2.4071614359087854,-0.10791253841717666,-0.8699343008139493,1.8222377186127818,3.8304852644801137,-0.5021316919187672,0.19301386899346543,1.5167285531774126,-0.5208177336190014,-1.5373416114687155,0.3997325317718629,0.43080383738421585,-0.558403728184664,0.8184979173823138,0.1604504658814682,1.2590315225380515,-0.373271876429598,0.06148252180205109,-0.8298890333091614,0.9180915884762,0.33701658189477507,-0.0907134950668146,1.750489731196436,0.8041129767098191,1.2192696206606266,-0.7901703605422196,-0.7311921139115007,2.481322052038954,-0.7901703605422196,0.4923857069491886,-0.373271876429598,0.7315827923762055,0.98808050071691,0.17675834803240076,1.0845146796370766,-0.0564914375226667,-0.9103121062691136,0.8041129767098191,-0.7901703605422196,0.44626893355334946,-0.2832385860448953,0.47705956297724367,-0.8900812583352817,0.41529180787632924,-0.30111518243997987,-0.3914762369552328,0.5076661391022604,-0.22999085661134913,1.0981470112960925,2.2667166943530197,0.522901157152449,1.8341031346457968,0.9180915884762,-0.1948058268211105,-0.6922649775615227,0.9601976189085124,-0.2832385860448953,0.32121625895525563,1.4279535786684734,0.6875712647067221,0.09468784334280253,0.2735187641595761,1.4279535786684734,0.43080383738421585,1.6287336796515217,0.7896879996375533,-0.596278947334594,-1.333816816277065,1.402314093228658,-0.0564914375226667,-0.6922649775615227,0.7896879996375533,0.7315827923762055,-0.22999085661134913,-0.0907134950668146,-0.02250118346835699,-1.400695436287198,2.364329913882264,0.04479749007284595,-0.02250118346835699,-1.0127520150653435,-0.31905629408571334,-0.8699343008139493,2.7583811399319984,-0.0564914375226667,-1.0127520150653435,0.5833929390939195,-4.1411192303358,1.798428045397234,-0.7901703605422196,0.4616874064468927,-0.6922649775615227,2.983960149974089,2.2994483251380298,-0.7116898323792509,1.4534696782308594,2.189571052524327,0.09468784334280253,-0.3914762369552328,0.02805701137235168,0.4616874064468927,0.02805701137235168,-0.03946755021715677,1.798428045397234,0.8328430643605732,1.4534696782308594,0.9321647887240839,-2.2874512966961964,0.2894676887918951,-0.26542599868242417,-1.445808727840182,0.11120892157867891,1.7625145060761207,-0.2123673195994045,0.3841256925736641,0.07811250742307049 3430 Mitochondrial transmembrane transport 27 51 4.106059328274172 4.024661523116535e-05 P21796,P24539,O60830,O95202,Q96NB2,Q9BQT8,O95831,P23786,P12236,P06576,Q9Y619,O75964,Q9H2D1,Q9UJS0,O43615,Q9BSK2,O75746,O14925,Q99595,Q00325,P12235,O43772,Q8IYU8,P56385,Q6P4A7,P05141,Q9NUT2 Processes and pathways GO Biological process msigdb_gobp 9,138,20,401,410,157,414,33,418,674,45,47,49,708,565,61,692,204,78,214,213,468,347,726,232,736,519 204,565,468,20,763,1532,692,3081,47,1098,401,839,414,1443,736,674,3180,213,418,9,33,138,2925,1257,3379,1058,1100,2080,726,214,900,1338,968,232,347,1130,2565,1236,410,78,157,61,49,1409,942,1867,519,708,1530,1025,45 1.6777690135569574,0.7752227411673067,0.9462000577616902,3.2100435371001237,0.5532361269354006,-0.005591913085313469,0.6282990804246098,-1.0335027512907717,2.748363067010926,0.25751962221115077,1.0981470112960925,0.4616874064468927,1.07084676596474,0.04479749007284595,0.5833929390939195,0.6431811538013191,-1.1813127889529935,1.641034754600386,1.057143066123191,3.489279818123242,3.0318170762153325,1.9744867066455778,-0.8699343008139493,0.1604504658814682,-2.0237575733036444,0.2894676887918951,0.25751962221115077,-0.26542599868242417,0.5984052493734849,1.641034754600386,0.41529180787632924,0.11120892157867891,0.3527680424371989,1.5792439505261,1.2458108826688405,0.24146991514915547,-0.558403728184664,0.17675834803240076,1.0845146796370766,2.3750691920218543,1.8813049364421908,2.5336885717746562,2.7383268943293446,0.07811250742307049,0.3841256925736641,-0.15986707294579158,0.8756421363992508,0.6282990804246098,0.01126068031324202,0.32121625895525563,2.7982738550861823 3430 Predicted secreted proteins 25 53 4.036152755016526 5.433484655803511e-05 Q8WUJ1,P80303,P61916,O14786,Q15165,P04083,Q6P179,P43490,Q9HB40,Q08380,O94919,Q9UM22,O60888,Q9Y4P3,Q9NZ08,Q9Y287,Q14667,Q9BTY2,P05067,O75718,O00584,Q9BUR5,Q08431,Q02818,O60568 Functions Protein Atlas Protein class protein_atlas_protein_class 129,5,512,520,139,148,407,39,40,298,176,51,52,313,185,190,577,202,205,89,467,613,503,246,376 467,520,376,52,89,735,176,1314,148,205,2352,1952,1953,1359,1255,1995,1223,2148,1316,3328,3099,3032,39,1289,1712,512,608,5,246,742,298,503,2993,577,139,407,3355,880,129,1237,716,848,1760,202,613,3077,850,40,185,51,2138,190,313 0.9462000577616902,0.861414936766202,1.1657819605638418,2.6675608037921723,2.2994483251380298,0.5833929390939195,1.798428045397234,0.1276761298241045,1.904751655596212,1.6777690135569574,-0.40974773902190176,-0.2123673195994045,-0.2123673195994045,0.09468784334280253,0.1604504658814682,-0.22999085661134913,0.17675834803240076,-0.30111518243997987,0.1276761298241045,-1.6543045466896755,-1.0543430004362901,-0.971515740451046,2.983960149974089,0.14408985151272588,-0.0907134950668146,0.8756421363992508,0.7169539114401163,3.8304852644801137,1.5167285531774126,0.5833929390939195,1.3636206339195902,0.8898304908049921,-0.9306276139125141,0.7607169539788241,1.9744867066455778,1.0845146796370766,-1.8230922651443087,0.43080383738421585,2.0547236877093185,0.17675834803240076,0.6133738705970863,0.4616874064468927,-0.10791253841717666,1.7142527679704935,0.7169539114401163,-1.0127520150653435,0.4616874064468927,2.983960149974089,1.774512395985724,2.677725710562994,-0.2832385860448953,1.7625145060761207,1.3246420617522143 3430 Sphingolipid metabolism 16 26 3.983344164395988 6.795223617572788e-05 Q06136,O15269,P17900,P10619,P07602,O15270,P16278,P51648,Q9NZJ7,P06865,P06280,O95470,Q13510,P22059,Q96G23,P04062 Processes and pathways Reactome Pathways msigdb_reactome 258,286,66,226,38,295,43,110,341,268,275,86,250,316,124,30 856,286,295,553,1993,86,30,275,268,38,1358,226,983,43,66,316,501,110,258,250,124,340,2830,591,341,1734 0.44626893355334946,1.3894476706931538,1.3636206339195902,0.7896879996375533,-0.22999085661134913,2.321161071650228,3.0603364192521147,1.4151493408700357,1.4279535786684734,3.0127233121243298,0.09468784334280253,1.6040461907838122,0.33701658189477507,2.9065277890482055,2.4918352621956807,1.2984956621256847,0.8898304908049921,2.1784605959005607,1.4661818634308703,1.5041368739934033,2.066089721766653,1.2590315225380515,-0.7704316844994457,0.7461703883999292,1.2590315225380515,-0.0907134950668146 3430 Golgi apparatus 83 326 3.939904225396333 8.151414521440081e-05 P80303,P24390,Q92974,O60512,P50897,Q15392,P04062,O00461,Q13190,Q16706,Q6ZRP7,L0R6Q1,Q96SU4,P16278,Q969S3,Q8TB61,Q14108,Q5VW38,Q5VYK3,O15127,Q9BTU6,P54646,Q9NXE4,Q9UL01,Q9BRK5,Q99523,Q6NTF9,Q9Y2T2,Q8IZA0,O43731,O15260,Q9BUR5,Q92542,Q9Y282,P46934,Q9NPR9,O75503,O15118,Q8IV08,Q7LGA3,Q9P2W9,O95197,Q9UQB8,O14773,Q8N2A8,Q8N4A0,Q9H8H2,Q9Y287,P05067,Q96PU5,Q9NX40,Q93050,Q9NQX7,O60476,P04439,Q02818,Q92544,Q8TBA6,Q92896,P35613,P06280,Q14457,Q10713,P22059,O43852,Q96L58,Q13535,P42345,Q96RL7,P01889,Q4J6C6,O60568,P10321,Q5T9L3,P42858,Q10472,O14744,Q8IY95,Q8NBN3,Q9Y3B3,Q9H7Z7,P25398,Q8NF37 Localization GO Cellular component msigdb_gocc 5,6,526,18,22,23,30,31,541,551,552,549,564,43,560,55,60,68,71,72,587,75,591,79,81,600,597,617,93,97,98,613,612,102,103,107,104,109,120,128,131,132,150,162,164,172,178,190,205,211,212,220,225,227,244,246,247,272,273,270,275,287,292,316,321,339,338,353,358,369,371,376,393,449,447,456,461,463,464,466,474,495,506 3327,549,2026,1662,1559,1389,31,3418,1773,2347,461,162,2428,1353,1218,109,72,818,98,3322,959,926,2454,3308,752,97,2501,960,1027,321,837,227,18,376,1143,2219,2430,2220,2257,1186,104,2351,782,2818,132,1390,672,1993,2285,3323,1219,1144,1910,1702,2923,3151,369,858,30,244,607,205,275,1704,2034,1954,3126,3233,859,393,676,1509,1995,43,3257,2858,1609,1610,1147,3127,2385,316,3163,6,495,3048,3064,2800,3085,965,3293,2074,1031,270,1641,3068,2413,3226,353,447,2835,103,2290,1914,677,796,910,2928,2079,1192,1363,22,1364,3206,694,1011,966,805,1964,2953,1712,75,3219,2970,2292,2644,1291,1149,2186,3203,2043,3341,2004,1419,1331,5,2484,3013,1783,1450,2934,246,2364,1578,3304,914,875,456,2557,292,2993,743,1716,541,1922,1260,1483,2704,338,3015,2295,2436,1423,60,2881,287,2155,1202,989,2389,1718,1488,2237,809,2560,23,1126,2561,551,371,449,2841,68,71,1263,2906,2300,597,1234,1151,2726,1650,2977,2610,552,2845,128,1897,730,2654,3092,3072,1795,2958,902,1724,766,120,2160,463,93,164,2678,172,1932,2728,464,1079,2117,880,506,1020,55,272,639,1377,1301,1497,1082,612,247,1208,3156,273,526,220,716,560,2611,3255,3055,339,1550,1657,2684,211,358,792,1526,564,600,2015,1727,3135,1590,3267,2313,1211,81,587,1087,613,939,3239,1066,1591,1941,3172,3076,3231,2206,905,1659,2735,748,474,178,2850,2982,850,2764,1944,107,225,1384,1213,1803,851,212,591,1246,1734,1804,131,2249,2687,1068,3096,2104,3278,79,2944,668,1348,956,2315,1349,1598,150,2895,102,190,2572,1991,1768,617,3137,3222,1945,466,1054,944,2140,1410,3176,2068 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3430 Primary mitochondrial disease 26 97 3.934762576792589 8.327897900017867e-05 Q96CU9,Q9UBX3,Q70HW3,Q9Y2R0,O43676,O14949,Q9BQT8,P00403,Q9P0J0,O95831,Q99797,O75306,Q86Y39,P08574,Q9NWS8,Q9Y6M9,Q9NPL8,P03886,Q6DKK2,P13073,P12235,Q9BW92,Q6P4A7,P14854,Q9Y584,O60313 Drugs and Diseases Protein Atlas Disease involvement protein_atlas_disease_involvement 274,13,16,19,21,155,157,28,158,414,290,413,168,296,182,326,325,73,82,336,213,485,232,363,119,375 892,1950,155,21,2922,1142,375,1441,413,978,1442,2321,1029,2033,414,28,73,2035,296,723,213,336,363,3331,2639,1119,984,2925,3031,1747,740,1395,2507,1075,2602,3152,2669,2483,1034,1333,3070,742,1673,951,651,1262,2157,680,2092,626,82,232,16,525,1424,3073,168,746,1493,2197,920,935,2565,1459,274,1001,972,1865,937,290,3041,1325,157,2518,485,1408,816,1660,1089,325,182,2133,749,158,3124,13,1350,19,1280,488,2024,2523,1531,2616,119,1601,326 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3430 Anion transmembrane transporter activity 27 43 3.9238519635325937 8.714429617828756e-05 P21796,P51798,Q9UBX3,P45880,P53985,P30825,Q9C0H2,Q96NB2,Q9Y6M7,Q9BQT8,P12236,Q4KMQ2,P11166,Q9Y619,Q9H2D1,Q9UJS0,O43681,Q9Y277,Q8TB61,Q15043,Q6NUK1,O75746,P55011,O43808,Q9BXP2,P12235,Q14728 Functions GO Molecular function msigdb_gomf 9,524,13,15,271,402,24,410,548,157,418,163,676,45,49,708,553,309,55,191,580,692,574,573,601,213,638 2852,553,573,692,839,736,1567,859,676,213,418,9,402,15,524,1100,271,574,696,638,191,950,163,3386,580,2193,996,55,410,792,1552,157,601,24,49,1409,942,13,708,309,45,3419,548 -0.8099892376198776,0.7896879996375533,0.7607169539788241,0.6282990804246098,0.4616874064468927,0.5833929390939195,-0.02250118346835699,0.44626893355334946,0.6431811538013191,1.641034754600386,1.057143066123191,3.489279818123242,1.0981470112960925,3.2925394092933984,0.861414936766202,0.25751962221115077,1.4279535786684734,0.7607169539788241,0.6282990804246098,0.6875712647067221,1.750489731196436,0.36847097049977656,1.8577557582221775,-2.1012974711813244,0.7607169539788241,-0.31905629408571334,0.33701658189477507,2.606176282501621,1.0845146796370766,0.522901157152449,-0.005591913085313469,1.8813049364421908,0.7315827923762055,3.1356876574429107,2.7383268943293446,0.07811250742307049,0.3841256925736641,3.391761695054266,0.6282990804246098,1.3376668826640072,2.7982738550861823,-3.6748723761247377,0.8184979173823138 3430 Inorganic molecular entity transmembrane transporter activity 33 71 3.9235792004543 8.724306634078083e-05 P20020,P21796,P24539,P51798,Q7KZN9,Q9UBX3,P16615,P45880,Q13423,O95202,Q9H0U3,Q9C0H2,Q9Y6M7,P00403,Q99797,Q4KMQ2,Q9HD20,Q96ES6,P08574,Q9Y487,O75964,O43681,Q9Y277,Q15043,P55011,Q9UDW1,P13073,Q9BXP2,Q00325,P12235,Q6P4Q7,Q93050,P14854 Functions GO Molecular function msigdb_gomf 385,9,138,524,525,13,269,15,146,401,536,24,548,28,290,163,35,37,296,175,47,553,309,191,574,74,336,601,214,213,598,220,363 2852,553,3081,47,401,28,607,736,674,1221,1952,2146,1567,296,859,840,213,336,363,269,385,1119,3191,3343,9,819,138,2925,784,1257,2149,2748,15,1075,3379,524,574,2080,726,1259,1014,214,2464,696,146,191,163,3386,598,525,996,1130,882,220,37,792,290,601,24,536,1409,35,13,74,2136,668,309,175,2067,3419,548 -0.8099892376198776,0.7896879996375533,-1.0335027512907717,2.748363067010926,1.0981470112960925,3.0698107589013315,0.7169539114401163,0.5833929390939195,0.6431811538013191,0.17675834803240076,-0.2123673195994045,-0.30111518243997987,-0.02250118346835699,1.3636206339195902,0.44626893355334946,0.4616874064468927,1.641034754600386,1.2590315225380515,1.1925938145223307,1.4279535786684734,1.1388325289942267,0.24146991514915547,-1.2028041638743916,-1.7500104946959263,3.489279818123242,0.47705956297724367,1.9744867066455778,-0.8699343008139493,0.522901157152449,0.1604504658814682,-0.30111518243997987,-0.7116898323792509,3.2925394092933984,0.2735187641595761,-2.0237575733036444,0.861414936766202,0.7607169539788241,-0.26542599868242417,0.5984052493734849,0.1604504658814682,0.32121625895525563,1.641034754600386,-0.4835161673691688,0.6282990804246098,1.9280968875332776,1.750489731196436,1.8577557582221775,-2.1012974711813244,0.7315827923762055,0.861414936766202,0.33701658189477507,0.24146991514915547,0.43080383738421585,1.6287336796515217,3.0222783212407616,0.522901157152449,1.3894476706931538,0.7315827923762055,3.1356876574429107,0.8328430643605732,0.07811250742307049,3.0318170762153325,3.391761695054266,2.4178172840822203,-0.2832385860448953,0.65802036299361,1.3376668826640072,1.8103460646896083,-0.24767692023999524,-3.6748723761247377,0.8184979173823138 3430 Membrane protein complex 95 302 3.914084415553532 9.074788638230302e-05 Q99623,Q9NS69,P21796,P51798,P45880,O95168,O60830,O43676,Q9H0U3,Q9C0H2,Q8N511,P00403,Q9UGP8,Q13190,O75964,Q9Y5J7,Q13505,P14406,P03886,Q9UDW1,Q99595,Q6NTF9,Q13438,Q9Y2T2,Q9NVH1,Q9BUR5,Q92542,Q8N4H5,P05023,O96000,Q8TCJ2,Q5XKP0,Q9Y584,O95487,Q9H490,Q9P2W9,P24539,O14949,Q9P0J0,Q4KMQ2,Q86Y39,P06576,O75438,P67812,Q9Y487,O95249,Q9NR28,P21912,Q6UXV4,Q9NPA0,O43292,O14925,Q15041,Q9NX63,Q03519,Q6IQ23,P12235,Q03518,Q93050,Q9Y5M8,P04439,O14678,Q53GQ0,Q9UBU6,O00560,Q96CU9,Q9Y512,Q14457,Q8TCT9,O15269,P08574,O15270,Q9Y277,Q9Y6M9,P13073,Q8IYU8,Q9BUN8,P14854,P04844,O94901,P01889,P51970,Q9UBV2,P10321,P51571,O75306,P12236,Q13277,Q9UH99,P46977,Q07666,Q9Y3B3,Q16891,Q15904,Q9NUT2 Localization GO Cellular component msigdb_gocc 517,7,9,524,15,529,20,21,536,24,25,28,547,541,47,571,58,64,73,74,78,597,596,617,616,613,612,101,607,606,628,626,119,618,640,131,138,155,158,163,168,674,671,173,175,672,705,693,697,703,194,204,713,732,215,729,213,218,220,236,244,257,262,265,266,274,278,287,289,286,296,295,309,326,336,347,366,363,362,368,369,386,397,393,403,413,418,427,434,430,448,466,479,490,519 2026,892,2852,1389,1437,1950,266,1773,2347,257,3148,204,155,1738,286,295,1071,959,926,194,21,2922,2501,3179,1009,1699,20,1441,413,1356,978,1186,1010,2319,671,1442,3081,802,47,1098,2897,2178,368,2071,2947,529,3008,1639,672,2033,1605,618,1702,606,1443,28,369,1314,73,244,872,362,1220,607,736,1607,674,1221,1952,1567,296,1954,1359,3126,3233,1392,2965,393,840,3180,1509,213,418,336,64,363,1538,3331,2770,2109,3303,2619,2639,1119,3191,3343,9,693,3163,984,2457,138,2925,3064,3031,2641,2598,1747,784,2288,1190,1781,1031,1257,2149,2748,3050,2228,2601,820,15,1396,430,1075,3379,2290,796,2184,910,3152,403,524,1011,386,2953,1712,986,2670,1573,1574,2553,2387,1916,2080,726,3390,1750,2930,1259,1014,2836,3203,2932,1419,2804,1643,1197,173,1783,218,215,1784,448,988,1578,3204,3035,1166,541,427,1260,596,2704,58,1228,3015,1484,1321,1787,287,2155,877,1618,713,3184,2237,900,1126,490,3131,1673,479,968,163,262,951,790,1037,626,812,729,597,697,168,902,756,996,347,1494,101,25,1426,2680,880,1130,2681,628,289,2682,1043,612,1208,1083,2422,220,1378,1624,1155,274,1270,972,3055,2759,3158,2761,792,1272,78,517,2539,1462,1590,2062,366,613,3422,24,1554,536,905,1466,640,2982,3003,1867,703,705,1213,7,519,616,3122,732,2446,158,1050,131,1871,2249,2473,265,397,2814,74,547,434,2136,2522,2344,3375,1632,956,2402,1350,309,1696,617,466,175,1025,278,119,571,2067,236,924,1410,1771,3419,3176,1558,326 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3430 Steroid metabolic process 31 71 3.859054123127185 0.0001138267292912 Q9BQE5,P30536,Q53GQ0,P61916,P38435,O14734,Q06520,Q15392,Q14849,P04062,P37268,O14975,Q8WTV0,Q96SU4,P28288,O75477,P22059,P54646,P05067,Q16850,O75845,O95470,Q15800,Q14739,P05023,P16435,Q14534,O15118,Q13510,P35610,O76062 Processes and pathways GO Biological process msigdb_gobp 0,2,262,512,136,391,144,23,27,30,166,424,169,564,555,566,316,75,205,210,470,86,88,222,607,231,122,109,250,252,382 391,424,109,566,470,382,2070,86,1876,30,607,205,3287,3301,2697,3141,231,316,2261,1997,2354,555,2,928,252,166,136,2183,2776,753,1258,2509,1194,1855,3383,75,2081,512,2607,3312,2187,144,250,3254,122,222,27,3220,23,1299,2190,1169,88,210,262,812,1623,169,3000,564,1837,0,2128,1553,3380,1659,632,2135,767,760,3097 1.125305736257329,1.04340337414266,2.1784605959005607,0.7752227411673067,0.9462000577616902,1.1523245386286525,-0.26542599868242417,2.321161071650228,-0.1773059016141884,3.0603364192521147,0.7169539114401163,1.6777690135569574,-1.4913543909405875,-1.5373416114687155,-0.6729168790091554,-1.117409393747407,1.5792439505261,1.2984956621256847,-0.35513411913799386,-0.22999085661134913,-0.40974773902190176,0.7896879996375533,3.92901774642917,0.3841256925736641,1.4915153034770001,1.8459424393187207,1.9975331678372859,-0.31905629408571334,-0.7311921139115007,0.5683366593475094,0.1604504658814682,-0.5208177336190014,0.19301386899346543,-0.15986707294579158,-2.0753063910430853,2.4071614359087854,-0.26542599868242417,0.8756421363992508,-0.596278947334594,-1.5605037593216007,-0.31905629408571334,1.9513415899455118,1.5041368739934033,-1.3560056220962575,2.077431989617715,1.6164042064007391,3.0792691433168833,-1.267862233870033,3.1543688124281597,0.14408985151272588,-0.31905629408571334,0.20921739577808898,2.310315469590055,1.6655522802639968,1.4534696782308594,0.4923857069491886,-0.03946755021715677,1.8459424393187207,-0.9306276139125141,0.7896879996375533,-0.1424888753229872,3.937153403770652,-0.2832385860448953,-0.005591913085313469,-2.049460345691425,-0.0564914375226667,0.7022834886797121,-0.2832385860448953,0.5532361269354006,0.5683366593475094,-1.0335027512907717 3430 Mitochondrial respiratory chain complex assembly 17 39 3.8292633894629735 0.0001285273901487 O75306,P51970,Q9Y6M9,Q86Y39,P03886,Q69YU5,Q96CU9,Q9H061,Q6DKK2,Q9Y2R0,O43676,Q9Y512,Q15070,Q7L592,Q9BSK2,Q9P0J0,O95831 Processes and pathways GO Biological process msigdb_gobp 413,386,326,168,73,11,274,12,82,19,21,278,181,472,61,158,414 892,21,2922,1142,1441,413,671,1442,1029,529,2033,414,606,73,3031,1075,386,3070,181,3131,1673,11,82,472,168,1493,935,274,61,2518,12,816,2632,749,158,1350,19,278,326 0.41529180787632924,3.200802504118346,-0.8699343008139493,0.22536929144369766,0.04479749007284595,1.07084676596474,0.6431811538013191,0.04479749007284595,0.30536674022651894,0.8471486580863727,-0.24767692023999524,1.07084676596474,0.7169539114401163,2.4178172840822203,-0.971515740451046,0.2735187641595761,1.1388325289942267,-1.0127520150653435,1.7864835322979642,-1.096295452188383,-0.07357327446040215,3.4362955117330025,2.342788021416518,0.9462000577616902,1.8459424393187207,0.02805701137235168,0.3841256925736641,1.4279535786684734,2.5336885717746562,-0.5208177336190014,3.4362955117330025,0.4923857069491886,-0.6153265492951593,0.5833929390939195,1.8813049364421908,0.11120892157867891,3.2192694624153164,1.4151493408700357,1.2853737321434007 3430 Lipid biosynthetic process 64 154 3.788227312375687 0.0001517260006573 P30536,O75874,Q06136,O76062,Q53GQ0,Q9NP80,O14734,O00767,Q13315,O60512,Q8NCG7,Q15392,P04083,Q14849,P04062,Q14457,O15269,Q10713,P37268,Q9P035,O14975,Q8WTV0,Q96SU4,O15270,P28288,O95864,O15228,O75477,Q96N66,P22059,Q6IAN0,O43292,Q86YN1,P54646,Q9BTU6,Q9NWU1,Q9NXE4,Q16850,O75845,O95470,Q9H7Z7,Q15800,Q8NCC3,Q9NPH0,Q14739,Q8NBX0,Q9UG56,P42345,P52429,P05023,P16435,O60762,P48651,Q13510,Q9NUQ2,Q9UBM7,Q8TBX8,P27544,Q8NF37,Q14534,Q9H490,P35610,Q96G23,Q9NZ01 Processes and pathways GO Biological process msigdb_gobp 2,1,258,382,262,264,391,644,400,18,534,23,148,27,30,287,286,292,166,294,424,169,564,295,555,554,307,566,189,316,579,194,453,75,587,590,591,210,470,86,474,88,91,94,222,95,487,353,228,607,231,605,360,250,367,632,242,501,506,122,640,252,124,641 1184,2986,1389,1437,3427,644,391,424,307,286,295,3322,194,18,2256,605,566,782,470,1,382,3338,2070,86,1144,3389,554,3151,1876,30,148,607,1358,3301,1535,1223,2697,3141,3408,231,1444,3257,316,2261,1997,2354,501,2640,555,2,1318,252,166,2078,353,1961,2776,753,360,796,1258,228,1855,3383,1013,75,2969,2081,2648,3312,1450,2511,258,292,3423,400,250,2234,3254,876,287,122,222,27,3220,1016,23,1299,2190,1169,88,1720,210,1401,262,951,680,1170,579,823,746,453,1623,95,91,534,506,242,169,663,1237,1083,1378,717,3000,124,189,2203,1626,2761,564,1272,1837,1086,587,3422,904,3403,2128,1553,1629,940,3380,1659,640,474,264,94,2065,2342,851,367,590,591,641,294,1734,632,487,2687,767,760,2633,1024 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3430 Mitochondrial protein import 14 36 3.781716230194339 0.0001557508500289 Q9Y5J9,Q10713,Q8N4H5,Q9NS69,P21796,O14925,Q99595,O60830,Q9Y512,Q5JRX3,Q9Y584,P12235,Q13505,Q9Y5L4 Processes and pathways Reactome Pathways msigdb_reactome 193,292,101,7,9,204,78,20,278,85,119,213,58,125 204,565,20,2833,1010,1532,692,1098,1443,674,296,3180,213,418,9,2925,3050,1060,292,58,900,968,85,101,78,3001,1867,7,732,708,1350,278,119,571,193,125 1.6777690135569574,0.7752227411673067,3.2100435371001237,-0.7901703605422196,0.32121625895525563,-0.005591913085313469,0.6282990804246098,0.25751962221115077,0.04479749007284595,0.6431811538013191,1.3636206339195902,-1.1813127889529935,1.641034754600386,1.057143066123191,3.489279818123242,-0.8699343008139493,-0.992089953515064,0.2894676887918951,1.3765499068522848,2.5544966637542177,0.41529180787632924,0.3527680424371989,2.3319852246797077,2.211724229893288,2.3750691920218543,-0.9306276139125141,-0.15986707294579158,3.602417135580486,0.5984052493734849,0.6282990804246098,0.11120892157867891,1.4151493408700357,2.1113172784145564,0.7752227411673067,1.750489731196436,2.066089721766653 3430 Cellular lipid metabolic process 81 221 3.770538142341679 0.0001628959021915 Q99623,O75874,P61916,O60512,Q16134,P50897,Q8NCG7,P04062,O75844,P23786,P07602,Q9HB40,P16278,P28288,O95864,Q8NHP8,A1L0T0,O75477,Q6IAN0,P17900,O43808,P54646,Q9BTU6,Q9NWU1,O95470,Q15800,Q8NCC3,Q9NPH0,Q8NBX0,P51648,Q96G23,P07099,P04083,P37268,Q8WTV0,Q96N66,O43292,Q6NUM9,P52429,P16435,Q8TBX8,Q13510,P35610,Q06136,O14678,Q53GQ0,Q9NP80,P06865,P06280,O15254,Q14457,Q2TAA5,O15269,Q10713,Q9P035,O15270,Q9BWD1,O15228,P22059,Q15067,Q2T9J0,Q15118,Q9NZJ7,Q99519,A8MXV4,P48651,Q9NUQ2,Q15120,Q9UBV2,O14734,Q13315,O14975,Q86YN1,Q9BZF1,Q709F0,Q9H7Z7,Q9UG56,Q8N4Q0,Q9BT22,P27544,Q8NF37 Processes and pathways GO Biological process msigdb_gobp 517,1,512,18,533,22,534,30,32,33,38,40,43,555,554,53,54,566,579,66,573,75,587,590,86,88,91,94,95,110,124,141,148,166,169,189,194,216,228,231,242,250,252,258,257,262,264,268,275,285,287,288,286,292,294,295,304,307,316,319,320,329,341,340,350,360,367,389,397,391,400,424,453,458,457,474,487,492,494,501,506 54,3416,350,1184,2986,1389,1437,3427,644,257,391,424,307,285,286,295,3322,194,573,1161,18,2256,605,1356,2144,566,2381,782,2694,32,1,3338,2070,3323,86,1144,3389,554,3151,30,895,148,3421,1606,275,268,141,38,1358,3287,3358,3279,3028,1223,2697,3141,3408,43,231,1444,3257,66,2504,316,2261,33,2354,2434,501,2640,555,841,3344,3011,795,1318,928,252,166,3168,2078,948,740,929,1961,2776,1884,2802,753,360,796,1258,1058,2079,22,2509,110,1194,228,1855,3383,1013,75,2510,2969,512,2648,3312,1450,2511,2556,258,988,1578,1968,292,1969,3423,400,250,2234,3254,876,287,3413,319,329,389,3220,1016,88,533,1720,625,320,288,1401,262,951,680,953,1170,812,579,216,2193,823,457,746,453,1172,1128,1494,492,3425,1457,1207,95,91,534,506,53,242,1175,169,663,1237,1083,2338,1378,717,3000,124,189,2203,1626,2761,340,1272,517,1837,1085,1086,494,587,1047,3422,904,3403,304,1629,940,458,640,3424,474,816,40,264,94,2065,2342,851,3173,367,590,591,641,341,294,1734,397,487,2687,1386,1530,2660,1024,1216,768,2172 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3430 Sterol metabolic process 15 42 3.763513396669183 0.0001675427471452 Q9BQE5,P37268,P16435,Q8WTV0,P54646,P05067,O15118,Q06520,Q16850,Q15392,Q15800,Q14534,Q14849,Q14739,P04062 Processes and pathways GO Biological process msigdb_gobp 0,166,231,169,75,205,109,144,210,23,88,122,27,222,30 109,566,470,382,2070,1876,30,205,3301,2697,231,1997,928,252,166,2183,2776,753,1258,1855,3383,75,2081,512,2607,3312,144,3254,122,222,27,3220,23,1169,88,210,169,0,1553,632,2135,760 2.1784605959005607,0.7752227411673067,0.9462000577616902,1.1523245386286525,-0.26542599868242417,-0.1773059016141884,3.0603364192521147,1.6777690135569574,-1.5373416114687155,-0.6729168790091554,1.5792439505261,-0.22999085661134913,0.3841256925736641,1.4915153034770001,1.8459424393187207,-0.31905629408571334,-0.7311921139115007,0.5683366593475094,0.1604504658814682,-0.15986707294579158,-2.0753063910430853,2.4071614359087854,-0.26542599868242417,0.8756421363992508,-0.596278947334594,-1.5605037593216007,1.9513415899455118,-1.3560056220962575,2.077431989617715,1.6164042064007391,3.0792691433168833,-1.267862233870033,3.1543688124281597,0.20921739577808898,2.310315469590055,1.6655522802639968,1.8459424393187207,3.937153403770652,-0.005591913085313469,0.7022834886797121,-0.2832385860448953,0.5683366593475094 3430 Carboxylic acid transport 16 32 3.750825452438684 0.0001762533685396 O75746,Q02978,P55011,P07602,Q9NP80,Q9UBX3,Q9Y619,Q9NZJ7,P53985,Q9H2D1,P28288,Q9UJS0,P30825,P04083,Q96NB2,Q9BQT8 Processes and pathways GO Biological process msigdb_gobp 692,696,574,38,264,13,45,341,271,49,555,708,402,148,410,157 2408,692,1507,839,148,1607,38,1567,1223,2073,555,402,1100,271,574,1918,696,713,1488,950,2193,996,410,157,49,1409,942,264,341,13,708,45 -0.4464943548499513,0.6282990804246098,0.01126068031324202,0.4616874064468927,1.904751655596212,-0.03946755021715677,3.0127233121243298,-0.02250118346835699,0.17675834803240076,-0.26542599868242417,0.7896879996375533,1.0981470112960925,0.25751962221115077,1.4279535786684734,0.7607169539788241,-0.1948058268211105,0.6282990804246098,0.6133738705970863,0.02805701137235168,0.36847097049977656,-0.31905629408571334,0.33701658189477507,1.0845146796370766,1.8813049364421908,2.7383268943293446,0.07811250742307049,0.3841256925736641,1.4534696782308594,1.2590315225380515,3.391761695054266,0.6282990804246098,2.7982738550861823 3430 Cation transmembrane transport 40 120 3.738408739899719 0.0001851886918264 Q99623,P20020,P21796,P24539,Q7KZN9,P16615,Q70HW3,Q13423,P30825,O95202,Q9H0U3,Q96NB2,Q9Y6M7,P00403,Q9HD20,Q4KMQ2,Q96ES6,P08574,Q9Y619,O75964,Q96GC9,Q15043,P42858,P55011,Q9UDW1,Q06787,P05067,P13073,Q96PU5,Q9BXP2,Q6P4Q7,Q00325,P12235,O43772,Q8IYU8,P05023,P46934,Q9HD47,P14854,Q9NUT2 Processes and pathways GO Biological process msigdb_gobp 517,385,9,138,525,269,16,146,402,401,536,410,548,28,35,163,37,296,45,47,188,191,447,574,74,203,205,336,211,601,598,214,213,468,347,607,103,106,363,519 1772,1950,781,468,2832,763,1441,2031,1532,3081,47,401,28,607,205,736,1607,674,1221,1952,3082,2146,1567,296,2965,840,3301,213,336,363,269,1444,2109,3303,2504,385,1119,3191,3343,3127,9,819,138,2925,774,2640,2598,3166,402,784,3167,1257,2149,2748,447,103,1396,1075,3379,1192,1573,1574,574,2080,726,1259,1014,2555,1121,214,2464,2187,203,988,3204,1716,146,1669,1670,624,191,2237,950,163,598,1039,16,525,2161,347,1863,1130,1236,882,37,188,1499,410,211,3387,517,1590,601,536,2370,1409,942,35,106,519,1092,74,2687,2136,1530,668,2345,1025,45,548 -0.12517084870498654,-0.2123673195994045,0.522901157152449,0.9462000577616902,-0.7901703605422196,0.5532361269354006,0.04479749007284595,-0.24767692023999524,-0.005591913085313469,-1.0335027512907717,2.748363067010926,1.0981470112960925,3.0698107589013315,0.7169539114401163,1.6777690135569574,0.5833929390939195,-0.03946755021715677,0.6431811538013191,0.17675834803240076,-0.2123673195994045,-1.0335027512907717,-0.30111518243997987,-0.02250118346835699,1.3636206339195902,-0.9103121062691136,0.4616874064468927,-1.5373416114687155,1.641034754600386,1.2590315225380515,1.1925938145223307,1.4279535786684734,0.04479749007284595,-0.2832385860448953,-1.5373416114687155,-0.5208177336190014,1.1388325289942267,0.24146991514915547,-1.2028041638743916,-1.7500104946959263,-1.096295452188383,3.489279818123242,0.47705956297724367,1.9744867066455778,-0.8699343008139493,0.5380910558331444,-0.6344483133432426,-0.596278947334594,-1.1599171531024435,1.0981470112960925,0.522901157152449,-1.1599171531024435,0.1604504658814682,-0.30111518243997987,-0.7116898323792509,1.001966258000303,2.2006588969869694,0.07811250742307049,0.2735187641595761,-2.0237575733036444,0.19301386899346543,-0.02250118346835699,-0.02250118346835699,0.7607169539788241,-0.26542599868242417,0.5984052493734849,0.1604504658814682,0.32121625895525563,-0.558403728184664,0.24146991514915547,1.641034754600386,-0.4835161673691688,-0.31905629408571334,1.7021191193583658,0.33701658189477507,-1.2243922216969028,-0.0907134950668146,1.9280968875332776,-0.07357327446040215,-0.07357327446040215,0.7022834886797121,1.750489731196436,-0.33706243340680064,0.36847097049977656,1.8577557582221775,0.7315827923762055,0.30536674022651894,3.2651743542921823,0.861414936766202,-0.30111518243997987,1.2458108826688405,-0.15986707294579158,0.24146991514915547,0.17675834803240076,0.43080383738421585,3.0222783212407616,1.7625145060761207,0.02805701137235168,1.0845146796370766,1.6655522802639968,-2.1012974711813244,0.8756421363992508,-0.02250118346835699,0.7315827923762055,0.8328430643605732,-0.40974773902190176,0.07811250742307049,0.3841256925736641,3.0318170762153325,2.189571052524327,0.8756421363992508,0.2735187641595761,2.4178172840822203,-0.6536448751928122,-0.2832385860448953,0.01126068031324202,0.65802036299361,-0.3914762369552328,0.32121625895525563,2.7982738550861823,0.8184979173823138 3430 Dementia 25 58 3.7329375027682743 0.0001892595670041 P61916,P06865,P00403,P04062,P07602,Q9Y487,O43681,Q14108,Q9Y287,P04350,P42858,P17900,P31483,P03886,Q06787,P05067,Q9NZJ7,P22626,O76024,Q96RL7,P35637,O15118,P27544,Q13510,O60313 Drugs and Diseases Human Phenotype Ontology msigdb_hp 512,268,28,30,38,175,553,60,190,445,447,66,322,73,203,205,341,343,477,358,235,109,501,250,375 1559,109,553,375,870,477,1443,28,73,30,3349,445,205,268,38,981,2924,983,66,1446,693,343,1851,501,1747,322,235,2149,2748,447,585,2509,821,2387,512,741,3054,203,2418,250,60,1485,1262,2610,2393,1128,1206,663,2338,3158,358,937,3387,341,1529,190,175,3043 -0.02250118346835699,2.1784605959005607,0.7896879996375533,1.1657819605638418,0.43080383738421585,0.9321647887240839,0.04479749007284595,3.0698107589013315,2.4178172840822203,3.0603364192521147,-1.7986048232476497,1.001966258000303,1.6777690135569574,1.4279535786684734,3.0127233121243298,0.33701658189477507,-0.8699343008139493,0.33701658189477507,2.4918352621956807,0.04479749007284595,0.6282990804246098,1.2458108826688405,-0.15986707294579158,0.8898304908049921,-0.10791253841717666,1.2853737321434007,1.5667994320520733,-0.30111518243997987,-0.7116898323792509,1.001966258000303,0.7461703883999292,-0.5208177336190014,0.47705956297724367,-0.4280869276823581,0.8756421363992508,0.5833929390939195,-0.992089953515064,1.7021191193583658,-0.4464943548499513,1.5041368739934033,2.5336885717746562,0.02805701137235168,0.1604504658814682,-0.596278947334594,-0.4280869276823581,0.24146991514915547,0.19301386899346543,0.65802036299361,-0.3914762369552328,-1.1386163266404463,1.2192696206606266,0.3841256925736641,-2.1012974711813244,1.2590315225380515,0.01126068031324202,1.7625145060761207,1.8103460646896083,-0.971515740451046 3430 Dysphagia 32 137 3.711310935793693 0.0002061886421775 O75874,P61916,P48735,Q99720,P04062,O75306,P07602,Q14108,Q96D71,Q15067,P04350,P42858,P55011,P03886,Q06787,P05067,P15586,Q9NZJ7,Q99519,O75569,P12235,Q8IZA0,Q14739,O76024,Q96RL7,P35637,O15118,P01889,Q9UHX1,Q13510,Q9NR77,O60313 Drugs and Diseases Human Phenotype Ontology msigdb_hp 1,512,10,26,30,413,38,60,582,319,445,447,574,73,203,205,206,341,340,342,213,93,222,477,358,235,109,369,118,250,123,375 1559,2346,1438,109,2318,1142,375,870,1875,413,1442,342,1,477,2070,2947,1777,1993,1565,2618,369,73,30,445,205,2819,38,2596,2286,2597,1255,2856,213,206,1996,1956,1569,1446,2073,693,1393,3031,2576,1747,235,2413,1572,1961,1395,447,585,10,2509,1100,1713,821,574,2387,1290,1544,512,1815,1366,695,1576,1783,1334,807,3054,1165,3295,2608,2674,203,2045,2418,250,60,1485,2298,2113,222,319,1821,1078,1673,2676,2976,2610,824,2274,1796,93,933,1493,2010,2197,2395,1524,2338,582,2732,2758,3158,358,937,2312,885,340,1837,26,2124,1325,1463,2518,1241,904,3188,849,1409,1089,123,1022,2101,2102,341,1092,1529,975,955,118,3097,1598,2139,1216,2024,1025 -0.02250118346835699,-0.40974773902190176,0.04479749007284595,2.1784605959005607,-0.3914762369552328,0.22536929144369766,1.1657819605638418,0.43080383738421585,-0.1773059016141884,1.07084676596474,0.04479749007284595,1.2458108826688405,3.92901774642917,0.9321647887240839,-0.26542599868242417,-0.8900812583352817,-0.12517084870498654,-0.22999085661134913,-0.02250118346835699,-0.6153265492951593,1.179204988513675,2.4178172840822203,3.0603364192521147,1.001966258000303,1.6777690135569574,-0.7704316844994457,3.0127233121243298,-0.596278947334594,-0.373271876429598,-0.596278947334594,0.1604504658814682,-0.8099892376198776,1.641034754600386,1.6777690135569574,-0.22999085661134913,-0.2123673195994045,-0.02250118346835699,0.04479749007284595,-0.26542599868242417,0.6282990804246098,0.07811250742307049,-0.971515740451046,-0.5773048800496771,-0.10791253841717666,1.5667994320520733,-0.4464943548499513,-0.02250118346835699,-0.2123673195994045,0.07811250742307049,1.001966258000303,0.7461703883999292,3.454011813127605,-0.5208177336190014,0.25751962221115077,-0.0907134950668146,0.47705956297724367,0.7607169539788241,-0.4280869276823581,0.14408985151272588,-0.005591913085313469,0.8756421363992508,-0.1424888753229872,0.09468784334280253,0.6282990804246098,-0.02250118346835699,-0.12517084870498654,0.11120892157867891,0.4923857069491886,-0.992089953515064,0.20921739577808898,-1.5142922206614813,-0.596278947334594,-0.6536448751928122,1.7021191193583658,-0.24767692023999524,-0.4464943548499513,1.5041368739934033,2.5336885717746562,0.02805701137235168,-0.373271876429598,-0.2832385860448953,1.6164042064007391,1.2984956621256847,-0.1424888753229872,0.2735187641595761,-0.07357327446040215,-0.6536448751928122,-0.9103121062691136,-0.596278947334594,0.47705956297724367,-0.35513411913799386,-0.12517084870498654,2.2667166943530197,0.3841256925736641,0.02805701137235168,-0.22999085661134913,-0.31905629408571334,-0.4280869276823581,0.01126068031324202,-0.3914762369552328,0.7607169539788241,-0.6922649775615227,-0.7116898323792509,-1.1386163266404463,1.2192696206606266,0.3841256925736641,-0.373271876429598,0.43080383738421585,1.2590315225380515,-0.1424888753229872,3.107549151128594,-0.2832385860448953,0.1276761298241045,0.04479749007284595,-0.5208177336190014,0.17675834803240076,0.41529180787632924,-1.1813127889529935,0.4616874064468927,0.07811250742307049,0.2735187641595761,2.077431989617715,0.32121625895525563,-0.26542599868242417,-0.26542599868242417,1.2590315225380515,0.2735187641595761,0.01126068031324202,0.3527680424371989,0.36847097049977656,2.1113172784145564,-1.0335027512907717,-0.02250118346835699,-0.2832385860448953,0.19301386899346543,-0.22999085661134913,0.32121625895525563 3430 Vacuolar membrane 41 123 3.7012646304597454 0.0002145275967702 O14678,Q9UIQ6,P51798,Q8NCG7,Q9H0U3,Q8N511,Q14849,P04062,P07602,Q8WTV0,P33176,Q9H2V7,Q9Y487,Q9Y6I9,P10253,Q14108,Q96GC9,Q15043,P42892,Q9BTU6,Q9NZJ7,P42785,Q99519,Q8IY95,Q99523,Q16625,Q93050,Q9Y2T2,Q9NQX7,O15260,P10619,P42345,Q96RL7,O75503,P13473,O15118,P04844,P11117,Q8IV08,Q8NF37,Q07065 Localization GO Cellular component msigdb_gocc 257,137,524,534,536,25,27,30,38,169,425,46,175,572,311,60,188,191,69,587,341,207,340,463,600,346,220,617,225,98,226,353,358,104,237,109,362,370,120,506,253 2026,2347,257,109,98,1071,2501,2218,1355,2455,870,104,802,2071,1702,30,362,1952,38,2146,1567,1285,1954,3126,311,226,370,2108,646,237,1147,3191,3343,2859,2774,425,2149,2748,2228,353,207,69,2835,2461,1364,524,1011,986,2970,1291,2186,1259,2932,2804,1643,1890,1783,3295,253,1578,3204,2557,2234,60,27,191,2560,346,812,730,120,996,463,25,534,506,2395,169,2682,1497,612,220,1624,3075,1270,1461,188,2759,3158,358,340,600,2539,2887,587,3422,1941,3172,1136,536,905,1466,46,2736,225,1504,341,3271,1734,1050,1214,2136,137,1348,1845,956,1696,617,3222,175,2067,891,572 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3430 Translocation 19 48 3.678718311441899 0.0002344089925627 Q8TD16,Q9NS69,O60830,Q5SRE5,Q7Z3B4,Q99567,Q9Y5J7,O43615,Q9Y5J9,O14925,Q99595,P41208,Q9BTX1,Q8N1F7,Q12769,Q8NFH4,Q15629,Q9Y584,Q9Y5L4 Processes and pathways Protein Atlas Biological process protein_atlas_biological_process 639,7,20,662,559,42,571,565,193,204,78,344,92,611,478,627,116,119,125 1737,204,565,1775,20,1056,979,1706,657,1572,344,1915,862,1033,1195,3390,1014,2267,1815,478,116,968,1103,662,559,611,627,639,1267,1833,1899,747,793,42,78,92,2912,886,1983,1764,7,2343,1215,2894,119,571,193,125 -0.10791253841717666,1.6777690135569574,0.7752227411673067,-0.12517084870498654,3.2100435371001237,0.2894676887918951,0.33701658189477507,-0.0907134950668146,0.65802036299361,-0.02250118346835699,1.2458108826688405,-0.1948058268211105,0.44626893355334946,0.30536674022651894,0.19301386899346543,-2.153721952328721,0.32121625895525563,-0.35513411913799386,-0.1424888753229872,0.9321647887240839,2.133790611209967,0.3527680424371989,0.25751962221115077,0.65802036299361,0.7896879996375533,0.7169539114401163,0.7022834886797121,0.6875712647067221,0.1604504658814682,-0.1424888753229872,-0.1773059016141884,0.5833929390939195,0.522901157152449,2.916265686588943,2.3750691920218543,2.277649032464161,-0.8498704751461239,0.43080383738421585,-0.2123673195994045,-0.10791253841717666,3.602417135580486,-0.3914762369552328,0.19301386899346543,-0.8298890333091614,2.1113172784145564,0.7752227411673067,1.750489731196436,2.066089721766653 3430 Contractures of the joints of the upper limbs 19 73 3.6657147082546655 0.0002466487728789 Q7LGA3,Q6DKJ4,Q15392,Q99720,O75844,P23786,P37268,Q99567,Q9Y619,P42892,Q96L58,Q13535,Q8IZA0,Q96AY3,P16435,P48651,P35637,Q9NR77,O60568 Drugs and Diseases Human Phenotype Ontology msigdb_hp 128,406,23,26,32,33,166,42,45,69,339,338,93,357,231,360,235,123,376 1389,2107,2816,1438,2174,3060,837,2217,376,2143,32,2070,1777,1534,2819,1254,1256,231,896,3127,2859,33,738,2800,1813,235,166,69,3402,360,431,2079,2509,821,3129,1195,1450,1296,338,2235,1670,2113,2091,542,1488,23,406,2051,128,93,1833,1043,3346,2120,357,339,2312,42,26,2123,1087,2279,2540,1763,123,2875,1349,2170,2896,1436,2741,45,2172 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3430 Abnormal vertebral morphology 41 112 3.662872022611669 0.00024940315855 O75874,P61978,P48735,P51798,Q13045,Q9UM00,Q9UBN7,O95202,Q6DKJ4,P08236,P04062,O95831,Q32P28,Q10713,Q12768,P16278,Q9Y619,O15228,Q15427,Q9Y4P3,Q14108,Q6NUK1,Q6NUQ1,P15586,Q9UL01,Q99519,Q96L58,O75845,O96028,P54802,O75718,Q14739,P10619,Q8TAA9,Q96HY6,Q96AY3,P16435,Q9UBM7,Q9UHX1,P51812,O60568 Drugs and Diseases Human Phenotype Ontology msigdb_hp 1,387,10,524,531,668,666,401,406,279,30,414,34,292,550,43,45,307,312,313,60,580,452,206,79,340,339,470,334,87,89,222,226,482,380,357,231,632,118,619,376 2173,2107,977,1438,307,3322,3060,2350,837,2283,2663,376,1473,2574,89,470,1,2897,401,414,334,30,895,1284,279,226,1189,3412,206,43,231,1956,3191,3127,2073,3328,2262,1813,2775,3068,804,3050,3332,1710,10,2002,524,619,87,1195,2862,387,1815,2879,1034,1576,1450,1296,2364,292,550,531,2626,60,2114,222,2091,2299,312,1126,1169,34,1375,406,580,452,2786,2677,994,919,1154,2010,1079,482,2872,1237,357,2308,380,685,339,340,779,2279,850,2963,1903,2022,1092,1023,632,666,118,866,79,668,2170,1633,2917,313,2281,45 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3430 Abnormal form of the vertebral bodies 34 88 3.661721407139568 0.0002505262139307 O75874,P48735,P51798,Q13045,Q9UM00,Q9UBN7,O95202,P08236,O95831,Q32P28,Q10713,Q12768,P16278,Q9Y619,O15228,Q15427,Q9Y4P3,Q6NUK1,Q6NUQ1,P15586,Q99519,Q96L58,O75845,O96028,P54802,Q14739,Q8TAA9,Q96HY6,Q96AY3,P16435,Q9UBM7,Q9UHX1,P51812,O60568 Drugs and Diseases Human Phenotype Ontology msigdb_hp 1,10,524,531,668,666,401,279,414,34,292,550,43,45,307,312,313,580,452,206,340,339,470,334,87,222,482,380,357,231,632,118,619,376 2173,2107,977,1438,307,3322,3060,2350,837,2283,376,1473,2574,470,1,2897,401,414,334,895,1284,279,1189,206,43,231,1956,3191,3127,2073,3328,2262,1813,2775,3068,804,3050,3332,1710,10,2002,524,619,87,2862,1815,2879,1576,1450,1296,2364,292,550,531,2626,222,2091,2299,312,1126,34,1375,580,452,994,1154,2010,482,1237,357,2308,380,685,339,340,779,2963,1092,632,666,118,866,668,2170,1633,2917,313,45 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3430 Joint stiffness 18 56 3.647463565679012 0.0002648418517605 O75844,O75874,Q8TAA9,O76024,Q96AY3,P16435,P48735,P16278,P51648,O15460,P15586,P50402,Q13045,P01889,Q15427,Q9Y4P3,P54802,P08236 Drugs and Diseases Human Phenotype Ontology msigdb_hp 32,1,482,477,357,231,10,43,110,398,206,431,531,369,312,313,87,279 2107,977,1026,3322,398,2350,2283,2594,2284,1010,2145,32,1,477,1777,369,1534,279,206,43,231,896,3127,2775,10,431,2509,110,87,2879,1450,531,1670,2113,542,1488,2299,312,2051,1206,1040,482,2872,1043,2120,1624,357,2312,1087,1730,1944,2521,866,2066,1470,313 -0.2832385860448953,0.33701658189477507,0.30536674022651894,-1.6306790060749776,1.1117439633053623,-0.40974773902190176,-0.373271876429598,-0.596278947334594,-0.373271876429598,0.32121625895525563,-0.30111518243997987,3.050846065270086,3.92901774642917,0.9321647887240839,-0.12517084870498654,1.179204988513675,-0.005591913085313469,1.402314093228658,1.6777690135569574,2.9065277890482055,1.5792439505261,0.41529180787632924,-1.096295452188383,-0.7311921139115007,3.454011813127605,1.0296274822176772,-0.5208177336190014,2.1784605959005607,2.321161071650228,-0.8298890333091614,0.04479749007284595,0.8471486580863727,-0.07357327446040215,-0.2832385860448953,0.8184979173823138,0.02805701137235168,-0.373271876429598,1.3246420617522143,-0.24767692023999524,0.19301386899346543,0.30536674022651894,0.9321647887240839,-0.8099892376198776,0.30536674022651894,-0.2832385860448953,-0.03946755021715677,1.2192696206606266,-0.373271876429598,0.2735187641595761,-0.0907134950668146,-0.1948058268211105,-0.5208177336190014,0.44626893355334946,-0.24767692023999524,0.04479749007284595,1.3246420617522143 3430 Secretory granule membrane 22 72 3.6462662420510887 0.0002660782983392 Q5T9A4,P10321,O00264,P35613,Q4KMQ2,P07602,O14975,Q13277,P30519,P10253,Q969Q5,P61586,Q9NZJ7,P42785,Q93050,Q9NQX7,O15260,P13473,P01889,Q08431,Q8NF37,Q07065 Localization GO Cellular component msigdb_gocc 259,393,143,270,163,38,424,427,44,311,323,337,341,207,220,225,98,237,369,503,506,253 143,424,98,2832,1143,1355,2455,870,782,2071,369,1221,38,311,393,646,1509,237,1743,1316,1477,44,3166,3087,270,2228,207,1511,910,2461,1364,1011,2953,1292,1149,2186,337,1331,1714,1164,2648,253,503,2045,427,2089,1484,1321,809,163,1584,259,812,698,2393,506,1041,612,220,323,3075,2887,1941,536,1944,225,341,1734,760,1696,2067,2477 1.9513415899455118,1.04340337414266,2.2227671511588163,-0.7901703605422196,0.22536929144369766,0.09468784334280253,-0.4835161673691688,0.43080383738421585,0.522901157152449,-0.26542599868242417,1.179204988513675,0.17675834803240076,3.0127233121243298,1.3246420617522143,1.125305736257329,0.6728169776242082,0.01126068031324202,1.554325783520826,-0.10791253841717666,0.1276761298241045,0.02805701137235168,2.8378826071016987,-1.1599171531024435,-1.0335027512907717,1.4279535786684734,-0.33706243340680064,1.6777690135569574,0.01126068031324202,0.3997325317718629,-0.4835161673691688,0.09468784334280253,0.32121625895525563,-0.8900812583352817,0.14408985151272588,0.22536929144369766,-0.31905629408571334,1.2590315225380515,0.11120892157867891,-0.0907134950668146,0.20921739577808898,-0.6344483133432426,1.4915153034770001,0.8898304908049921,-0.24767692023999524,1.04340337414266,-0.26542599868242417,0.02805701137235168,0.1276761298241045,0.4923857069491886,1.8577557582221775,-0.02250118346835699,1.4661818634308703,0.4923857069491886,0.6282990804246098,-0.4280869276823581,0.8898304908049921,0.30536674022651894,0.7169539114401163,1.6287336796515217,1.2853737321434007,-1.0127520150653435,-0.8298890333091614,-0.1948058268211105,0.8328430643605732,-0.1948058268211105,1.6164042064007391,1.2590315225380515,-0.0907134950668146,0.5683366593475094,-0.07357327446040215,-0.24767692023999524,-0.4835161673691688 3430 Mitochondrial membrane organization 24 50 3.642967531367917 0.0002695128454108 P52789,Q9NS69,P45880,Q9Y512,O95202,Q9P0J0,P07900,O14737,Q9Y5Z4,Q15070,Q9Y5J7,Q13505,Q6UXV4,Q9Y5J9,Q9NX63,P12235,Q9NVH1,Q9BUR5,Q16891,P05141,Q9Y5L4,Q5XKP0,Q9Y584,O60313 Processes and pathways GO Biological process msigdb_gobp 510,7,15,278,401,158,656,165,50,181,571,58,697,193,732,213,616,613,479,736,125,626,119,375 2026,165,375,1603,1010,1098,401,1877,736,656,1878,2965,213,2598,2505,3218,3050,2776,15,2699,2040,2079,510,988,58,181,479,968,951,626,697,756,1521,997,1236,613,3002,7,616,732,158,1114,1350,1025,278,119,571,193,125,50 -0.24767692023999524,1.8459424393187207,1.1657819605638418,-0.03946755021715677,0.32121625895525563,0.25751962221115077,1.0981470112960925,-0.1773059016141884,0.5833929390939195,0.65802036299361,-0.1773059016141884,-0.9103121062691136,1.641034754600386,-0.596278947334594,-0.5208177336190014,-1.267862233870033,-0.992089953515064,-0.7311921139115007,3.2925394092933984,-0.6729168790091554,-0.24767692023999524,-0.26542599868242417,0.8756421363992508,0.33701658189477507,2.5544966637542177,1.7864835322979642,0.9321647887240839,0.3527680424371989,0.36847097049977656,0.7022834886797121,0.6282990804246098,0.5683366593475094,0.01126068031324202,0.33701658189477507,0.17675834803240076,0.7169539114401163,-0.9306276139125141,3.602417135580486,0.7169539114401163,0.5984052493734849,1.8813049364421908,0.25751962221115077,0.11120892157867891,0.32121625895525563,1.4151493408700357,2.1113172784145564,0.7752227411673067,1.750489731196436,2.066089721766653,2.68787200548125 3430 Organic acid transmembrane transport 16 29 3.63706619265532 0.0002757610836936 O75746,P08183,P23786,Q02978,O14678,P11166,Q9UBX3,Q9Y619,P53985,Q9H2D1,P28288,Q9UJS0,P30825,O43772,Q96NB2,Q9BQT8 Processes and pathways GO Biological process msigdb_gobp 692,159,33,696,257,676,13,45,271,49,555,708,402,468,410,157 257,468,2408,692,1507,839,1607,159,1567,676,33,555,402,1318,1058,1100,271,696,713,950,996,410,157,49,1409,942,13,708,45 1.4661818634308703,0.9462000577616902,-0.4464943548499513,0.6282990804246098,0.01126068031324202,0.4616874064468927,-0.03946755021715677,1.8695432160167267,-0.02250118346835699,0.6431811538013191,3.0318170762153325,0.7896879996375533,1.0981470112960925,0.1276761298241045,0.2894676887918951,0.25751962221115077,1.4279535786684734,0.6282990804246098,0.6133738705970863,0.36847097049977656,0.33701658189477507,1.0845146796370766,1.8813049364421908,2.7383268943293446,0.07811250742307049,0.3841256925736641,3.391761695054266,0.6282990804246098,2.7982738550861823 3430 Membrane organization 70 227 3.634043903426497 0.000279013352638 P46379,P30536,Q9P2W9,P57088,P52789,P49354,P61916,Q9NS69,P45880,P16615,Q9UQB8,Q9HCU5,P50897,Q15392,P04083,Q9ULX6,Q9Y512,Q14849,O95202,Q9P0J0,P07900,Q13190,O75844,P08183,Q86XL3,Q4KMQ2,O14737,Q14457,Q13277,O95249,Q9UH99,P50402,Q9Y5Z4,O15228,O43681,Q15070,Q9Y5J7,Q8NHH9,Q13505,P22059,Q6UXV4,Q96GC9,Q9Y5J9,Q9NPA0,Q9BZF1,P61586,Q15041,Q9NZJ7,Q8NFQ8,Q9NX63,Q7Z3C6,P12235,Q8N1F7,Q9NVH1,Q9BUR5,Q9H4A6,Q9NQC3,Q16891,Q96A33,P05141,O15118,O94901,Q5XKP0,Q15629,P53350,Q08431,Q9Y584,O60313,O95487,Q9Y5L4 Processes and pathways GO Biological process msigdb_gobp 256,2,131,511,510,635,512,7,15,269,150,665,22,23,148,667,278,27,401,158,656,541,32,159,161,163,165,287,427,672,434,431,50,307,553,181,571,568,58,316,697,188,193,703,458,337,713,341,83,732,730,213,611,616,613,748,359,479,379,736,109,368,626,116,502,503,119,375,618,125 2026,1559,1389,1249,2796,2347,2816,165,907,1353,1218,109,307,818,1071,959,553,1809,375,1313,3179,2430,1603,1356,2693,1186,1010,2145,979,32,802,1098,2897,368,2947,401,1390,672,1993,2285,1605,618,1534,148,1877,736,963,1952,656,2146,159,1954,1878,2965,2108,213,269,1444,2109,2900,2619,1446,316,2598,2505,2,3218,1911,3050,1961,2776,1884,15,3402,256,2835,2699,1914,635,910,2040,431,2079,1192,22,1364,3206,1011,510,502,2670,2553,511,1750,2292,2644,337,1014,512,2004,1331,1164,2086,1198,1450,2511,988,503,1716,2418,541,427,2704,58,2436,1485,1321,287,2114,27,1618,713,181,3130,1821,2330,2237,809,23,1126,116,479,968,163,1756,951,790,1375,1676,626,697,1586,730,1795,161,902,2275,756,1521,997,1172,611,2678,1932,1426,2959,3355,83,568,1757,1268,2682,1236,1082,3261,3156,1656,1524,379,1270,1428,188,778,2539,3135,1087,613,939,458,3380,905,3002,748,1801,665,2764,703,359,2521,1213,3395,7,616,1504,732,341,3271,2446,158,1734,1214,131,2814,434,2687,1114,2250,2344,667,1845,2689,956,2315,150,1350,1217,1470,3222,1025,278,119,571,193,125,2140,50,3176 -0.24767692023999524,-0.02250118346835699,0.07811250742307049,0.1604504658814682,-0.7507725016906376,-0.40974773902190176,-0.7704316844994457,1.8459424393187207,0.3997325317718629,0.09468784334280253,0.17675834803240076,2.1784605959005607,1.3376668826640072,0.47705956297724367,0.2735187641595761,0.3527680424371989,0.7896879996375533,-0.1424888753229872,1.1657819605638418,0.1276761298241045,-1.1813127889529935,-0.4649705794159142,-0.03946755021715677,0.09468784334280253,-0.6729168790091554,0.19301386899346543,0.32121625895525563,-0.30111518243997987,0.33701658189477507,3.050846065270086,0.4923857069491886,0.25751962221115077,-0.8498704751461239,1.179204988513675,-0.8900812583352817,1.0981470112960925,0.07811250742307049,0.6431811538013191,-0.22999085661134913,-0.373271876429598,-0.03946755021715677,0.7022834886797121,-0.005591913085313469,1.904751655596212,-0.1773059016141884,0.5833929390939195,0.3527680424371989,-0.2123673195994045,0.65802036299361,-0.30111518243997987,1.8695432160167267,-0.2123673195994045,-0.1773059016141884,-0.9103121062691136,-0.2832385860448953,1.641034754600386,1.4279535786684734,0.04479749007284595,-0.2832385860448953,-0.8498704751461239,-0.6153265492951593,0.04479749007284595,1.2984956621256847,-0.596278947334594,-0.5208177336190014,3.92901774642917,-1.267862233870033,-0.1948058268211105,-0.992089953515064,-0.2123673195994045,-0.7311921139115007,-0.1773059016141884,3.2925394092933984,-2.425193190684344,1.47886368568901,-0.7901703605422196,-0.6729168790091554,-0.1948058268211105,0.6875712647067221,0.3997325317718629,-0.24767692023999524,1.0296274822176772,-0.26542599868242417,0.19301386899346543,3.191546309151074,0.09468784334280253,-1.2460779206914567,0.32121625895525563,0.8756421363992508,0.8898304908049921,-0.6536448751928122,-0.558403728184664,0.8756421363992508,-0.10791253841717666,-0.373271876429598,-0.6344483133432426,1.2590315225380515,0.32121625895525563,0.8756421363992508,-0.22999085661134913,0.11120892157867891,0.20921739577808898,-0.26542599868242417,0.19301386899346543,0.04479749007284595,-0.5208177336190014,0.33701658189477507,0.8898304908049921,-0.0907134950668146,-0.4464943548499513,0.8184979173823138,1.04340337414266,-0.6729168790091554,2.5544966637542177,-0.4649705794159142,0.02805701137235168,0.1276761298241045,1.3894476706931538,-0.2832385860448953,3.0792691433168833,-0.03946755021715677,0.6133738705970863,1.7864835322979642,-1.096295452188383,-0.1424888753229872,-0.3914762369552328,-0.33706243340680064,0.4923857069491886,3.1543688124281597,0.24146991514915547,2.133790611209967,0.9321647887240839,0.3527680424371989,1.8577557582221775,-0.10791253841717666,0.36847097049977656,0.522901157152449,0.09468784334280253,-0.07357327446040215,0.7022834886797121,0.6282990804246098,-0.02250118346835699,0.5984052493734849,-0.12517084870498654,1.8695432160167267,0.41529180787632924,-0.35513411913799386,0.5683366593475094,0.01126068031324202,0.33701658189477507,0.20921739577808898,0.7169539114401163,-0.6536448751928122,-0.1948058268211105,0.06148252180205109,-0.8900812583352817,-1.8230922651443087,2.342788021416518,0.7752227411673067,-0.10791253841717666,0.1604504658814682,-0.6536448751928122,0.17675834803240076,0.2735187641595761,-1.3782981393570042,-1.1386163266404463,-0.0564914375226667,0.01126068031324202,1.1657819605638418,0.1604504658814682,0.06148252180205109,1.7625145060761207,0.5380910558331444,-0.5395748804972572,-1.096295452188383,0.2735187641595761,0.7169539114401163,0.3841256925736641,0.9741576934609325,-2.049460345691425,0.41529180787632924,-0.9306276139125141,0.5833929390939195,-0.12517084870498654,0.65802036299361,-0.7116898323792509,0.6282990804246098,1.2192696206606266,-0.5208177336190014,0.19301386899346543,-2.2874512966961964,3.602417135580486,0.7169539114401163,0.02805701137235168,0.5984052493734849,1.2590315225380515,-1.4231985981949864,-0.4649705794159142,1.8813049364421908,-0.0907134950668146,0.19301386899346543,2.031919882590151,-0.7507725016906376,1.0296274822176772,-0.6536448751928122,0.25751962221115077,-0.33706243340680064,-0.3914762369552328,0.65802036299361,-0.1424888753229872,-0.6536448751928122,0.36847097049977656,-0.373271876429598,1.904751655596212,0.11120892157867891,0.19301386899346543,0.04479749007284595,-1.267862233870033,0.32121625895525563,1.4151493408700357,2.1113172784145564,0.7752227411673067,1.750489731196436,2.066089721766653,-0.2832385860448953,2.68787200548125,-1.1599171531024435 3430 Inorganic ion transmembrane transport 46 115 3.633884258549124 0.0002791861411375 Q99623,O75027,P20020,P27695,P21796,P24539,P51798,Q9UBX3,Q7KZN9,P16615,Q13423,Q9UM00,O95202,P31930,Q9H0U3,Q9Y6M7,P00403,Q9HD20,Q4KMQ2,Q96ES6,P06576,P08574,O75964,Q9UHG3,Q96GC9,Q15043,P42858,P55011,Q02978,Q9UDW1,Q06787,P13073,Q96PU5,Q9BXP2,Q6P4Q7,Q00325,P12235,P56385,Q8IYU8,P05023,P46934,Q9HD47,P05141,P14854,Q14BN4,Q9NUT2 Processes and pathways GO Biological process msigdb_gobp 517,763,385,774,9,138,524,13,525,269,146,668,401,784,536,548,28,35,163,37,674,296,47,57,188,191,447,574,696,74,203,336,211,601,598,214,213,726,347,607,103,106,736,363,624,519 1772,1950,781,2832,763,1441,2031,1532,3081,47,401,28,607,736,1607,674,1221,1952,2146,1567,296,2965,840,3301,213,336,363,269,1444,2109,3303,2504,385,1119,3191,3343,3127,9,819,138,2925,774,2640,2598,3166,784,3167,1257,2149,2748,447,103,1396,1075,3379,1192,524,1573,1574,574,2080,726,1259,1014,2555,1121,214,2464,696,2187,203,988,3204,1716,146,1669,1670,624,191,163,598,1039,525,996,2161,347,1863,1130,1236,882,37,188,1499,211,3387,517,1590,601,536,2370,1409,35,106,519,1092,13,74,2687,57,2136,1530,668,2345,1025,548 -0.12517084870498654,-0.2123673195994045,0.522901157152449,-0.7901703605422196,0.5532361269354006,0.04479749007284595,-0.24767692023999524,-0.005591913085313469,-1.0335027512907717,2.748363067010926,1.0981470112960925,3.0698107589013315,0.7169539114401163,0.5833929390939195,-0.03946755021715677,0.6431811538013191,0.17675834803240076,-0.2123673195994045,-0.30111518243997987,-0.02250118346835699,1.3636206339195902,-0.9103121062691136,0.4616874064468927,-1.5373416114687155,1.641034754600386,1.2590315225380515,1.1925938145223307,1.4279535786684734,0.04479749007284595,-0.2832385860448953,-1.5373416114687155,-0.5208177336190014,1.1388325289942267,0.24146991514915547,-1.2028041638743916,-1.7500104946959263,-1.096295452188383,3.489279818123242,0.47705956297724367,1.9744867066455778,-0.8699343008139493,0.5380910558331444,-0.6344483133432426,-0.596278947334594,-1.1599171531024435,0.522901157152449,-1.1599171531024435,0.1604504658814682,-0.30111518243997987,-0.7116898323792509,1.001966258000303,2.2006588969869694,0.07811250742307049,0.2735187641595761,-2.0237575733036444,0.19301386899346543,0.861414936766202,-0.02250118346835699,-0.02250118346835699,0.7607169539788241,-0.26542599868242417,0.5984052493734849,0.1604504658814682,0.32121625895525563,-0.558403728184664,0.24146991514915547,1.641034754600386,-0.4835161673691688,0.6282990804246098,-0.31905629408571334,1.7021191193583658,0.33701658189477507,-1.2243922216969028,-0.0907134950668146,1.9280968875332776,-0.07357327446040215,-0.07357327446040215,0.7022834886797121,1.750489731196436,1.8577557582221775,0.7315827923762055,0.30536674022651894,0.861414936766202,0.33701658189477507,-0.30111518243997987,1.2458108826688405,-0.15986707294579158,0.24146991514915547,0.17675834803240076,0.43080383738421585,3.0222783212407616,1.7625145060761207,0.02805701137235168,1.6655522802639968,-2.1012974711813244,0.8756421363992508,-0.02250118346835699,0.7315827923762055,0.8328430643605732,-0.40974773902190176,0.07811250742307049,3.0318170762153325,2.189571052524327,0.8756421363992508,0.2735187641595761,3.391761695054266,2.4178172840822203,-0.6536448751928122,2.5648713543162147,-0.2832385860448953,0.01126068031324202,0.65802036299361,-0.3914762369552328,0.32121625895525563,0.8184979173823138 3430 Respirasome 18 45 3.6297553917079575 0.0002836899252656 O75306,P14406,P51970,Q9Y6M9,Q86Y39,P03886,P08574,Q9UDW1,Q96CU9,Q7KZN9,P14854,Q13423,Q6DKK2,P13073,O43676,O14949,P00403,Q9P0J0 Localization GO Cellular component msigdb_gocc 413,64,386,326,168,73,296,74,274,525,363,146,82,336,21,155,28,158 892,1950,155,21,2922,1441,413,978,671,1442,529,3008,2033,606,28,73,296,1392,840,336,64,363,3331,2770,2639,1119,693,984,3031,1747,784,1075,3152,386,146,3131,1673,82,525,168,274,158,74,1350,326 0.41529180787632924,-0.2123673195994045,1.8813049364421908,3.200802504118346,-0.8699343008139493,0.04479749007284595,1.07084676596474,0.33701658189477507,0.6431811538013191,0.04479749007284595,0.8471486580863727,-0.9510285615071858,-0.24767692023999524,0.7169539114401163,3.0698107589013315,2.4178172840822203,1.3636206339195902,0.07811250742307049,0.4616874064468927,1.2590315225380515,2.5128016570172145,1.1925938145223307,-1.6780491319681583,-0.7311921139115007,-0.6344483133432426,0.24146991514915547,0.6282990804246098,0.33701658189477507,-0.971515740451046,-0.10791253841717666,0.522901157152449,0.2735187641595761,-1.1386163266404463,1.1388325289942267,1.9280968875332776,-1.096295452188383,-0.07357327446040215,2.342788021416518,0.861414936766202,1.8459424393187207,1.4279535786684734,1.8813049364421908,2.4178172840822203,0.11120892157867891,1.2853737321434007 3430 Organic anion transmembrane transporter activity 18 28 3.619134776706773 0.0002955896682952 Q6NUK1,O75746,P12236,Q02978,O43808,P11166,Q9UBX3,Q9Y619,P53985,Q9H2D1,Q9UJS0,P30825,Q8TB61,P12235,Q96NB2,Q9Y6M7,Q9BQT8,Q14728 Functions GO Molecular function msigdb_gomf 580,692,418,696,573,676,13,45,271,49,708,402,55,213,410,548,157,638 573,692,839,736,1567,676,213,418,402,1100,271,696,638,950,580,2193,996,55,410,1552,157,49,1409,942,13,708,45,548 0.7607169539788241,0.6282990804246098,0.4616874064468927,0.5833929390939195,-0.02250118346835699,0.6431811538013191,1.641034754600386,1.057143066123191,1.0981470112960925,0.25751962221115077,1.4279535786684734,0.6282990804246098,0.6875712647067221,0.36847097049977656,0.7607169539788241,-0.31905629408571334,0.33701658189477507,2.606176282501621,1.0845146796370766,-0.005591913085313469,1.8813049364421908,2.7383268943293446,0.07811250742307049,0.3841256925736641,3.391761695054266,0.6282990804246098,2.7982738550861823,0.8184979173823138 3430 Golgi membrane 62 136 3.612489721414312 0.0003032711314481 Q7LGA3,Q86Y82,Q9P2W9,O95197,P24390,P10321,Q8TBA6,Q92896,Q96S66,O60512,Q9UM00,P35613,Q15392,P49755,Q08379,O00461,Q13190,Q10713,Q16706,Q6ZRP7,L0R6Q1,P11166,Q15363,Q9BVK6,Q8N4A0,O95249,P49257,Q8TB61,Q14108,Q9Y287,P22059,O15258,Q5T9L3,P51572,Q9NTJ5,Q9H9S5,Q10472,Q9NXE4,Q9UL01,Q96L58,Q8NBN3,Q9Y3B3,Q6NTF9,Q7Z3C6,Q9H7Z7,Q8IZA0,P0CG08,Q9BUR5,O43731,O15260,Q9H4A6,P42345,Q9Y282,O60476,Q8NDZ4,Q8NF37,Q12907,P01889,P04439,Q10471,Q8IV08,O43505 Localization GO Cellular component msigdb_gocc 128,902,131,132,6,393,272,273,792,18,668,270,23,910,914,31,541,292,551,552,549,676,809,939,172,672,677,55,60,190,316,818,449,694,851,850,456,591,79,339,464,466,597,730,474,93,859,613,97,98,748,353,102,227,880,506,743,369,244,875,120,752 549,31,1773,2347,1218,818,98,959,926,752,97,2501,227,18,2430,2220,1186,132,672,2285,1910,369,244,1954,859,393,676,1509,1995,316,6,1031,270,3068,3226,353,2290,1914,677,910,1192,694,966,1964,2953,1712,3219,2970,2292,2644,1291,1149,2186,3203,2043,2004,2484,2364,3304,914,875,456,2557,292,743,541,1483,60,989,2389,2237,809,2560,23,1126,551,449,597,552,128,730,1795,902,1724,120,93,172,1932,2728,464,880,506,55,272,1301,1082,3156,273,3255,339,1657,792,1727,1211,613,939,3239,1941,2206,1659,748,474,2850,850,2764,1803,851,591,1734,131,2249,2687,3096,79,2944,668,1349,102,190,2572,1991,3137,3222,466,1054,1410 0.8041129767098191,3.050846065270086,-0.12517084870498654,-0.40974773902190176,0.17675834803240076,0.47705956297724367,2.2227671511588163,0.3527680424371989,0.3841256925736641,0.5683366593475094,2.233787760016152,-0.5208177336190014,1.5916594876052144,3.237676205824806,-0.4649705794159142,-0.33706243340680064,0.19301386899346543,2.0204818903795823,0.6431811538013191,-0.373271876429598,-0.1948058268211105,1.179204988513675,1.5292904957224467,-0.2123673195994045,0.44626893355334946,1.125305736257329,0.6431811538013191,0.01126068031324202,-0.22999085661134913,1.2984956621256847,3.713359366894026,0.30536674022651894,1.4279535786684734,-1.0127520150653435,-1.289746149293953,1.2192696206606266,-0.373271876429598,-0.1948058268211105,0.6431811538013191,0.3997325317718629,0.19301386899346543,0.6282990804246098,0.3527680424371989,-0.2123673195994045,-0.8900812583352817,-0.0907134950668146,-1.267862233870033,-0.9103121062691136,-0.373271876429598,-0.6344483133432426,0.14408985151272588,0.22536929144369766,-0.31905629408571334,-1.2243922216969028,-0.24767692023999524,-0.22999085661134913,-0.5021316919187672,-0.40974773902190176,-1.5373416114687155,0.3997325317718629,0.43080383738421585,0.9741576934609325,-0.558403728184664,1.3765499068522848,0.5833929390939195,0.8184979173823138,0.02805701137235168,2.5336885717746562,0.33701658189477507,-0.4280869276823581,-0.33706243340680064,0.4923857069491886,-0.558403728184664,3.1543688124281597,0.24146991514915547,0.8041129767098191,1.001966258000303,0.7315827923762055,0.8041129767098191,2.0547236877093185,0.5984052493734849,-0.12517084870498654,0.41529180787632924,-0.0907134950668146,2.1000456604552045,2.2667166943530197,1.8341031346457968,-0.1948058268211105,-0.6922649775615227,0.9601976189085124,0.43080383738421585,0.8898304908049921,2.606176282501621,1.4279535786684734,0.14408985151272588,0.2735187641595761,-1.1386163266404463,1.4279535786684734,-1.3560056220962575,1.2590315225380515,-0.0564914375226667,0.522901157152449,-0.0907134950668146,0.19301386899346543,0.7169539114401163,0.3841256925736641,-1.3117306703903504,-0.1948058268211105,-0.31905629408571334,-0.0564914375226667,0.5833929390939195,0.9462000577616902,-0.7901703605422196,0.4616874064468927,-0.7116898323792509,-0.12517084870498654,0.4616874064468927,0.7461703883999292,-0.0907134950668146,2.031919882590151,-0.33706243340680064,-0.6536448751928122,-1.0335027512907717,2.3750691920218543,-0.8699343008139493,0.65802036299361,0.11120892157867891,2.211724229893288,1.7625145060761207,-0.558403728184664,-0.2123673195994045,-1.096295452188383,-1.267862233870033,0.9601976189085124,0.30536674022651894,0.07811250742307049 3430 Muscle abnormality related to mitochondrial dysfunction 14 37 3.6097644994988376 0.0003064751249783 O75306,Q9Y6M9,Q9NPL8,Q9NP80,Q86Y39,P03886,Q96CU9,Q9UBX3,P14854,Q9Y2R0,O43676,P12235,O60313,P00403 Drugs and Diseases Human Phenotype Ontology msigdb_hp 413,326,325,264,168,73,274,13,363,19,21,213,375,28 892,1950,21,375,1441,413,978,1442,444,3045,606,28,73,213,363,2639,3031,1395,3152,2483,951,168,1493,935,2565,274,937,2518,1212,264,325,749,13,19,2024,1601,326 0.41529180787632924,-0.2123673195994045,3.200802504118346,1.1657819605638418,0.04479749007284595,1.07084676596474,0.33701658189477507,0.04479749007284595,1.001966258000303,-0.992089953515064,0.7169539114401163,3.0698107589013315,2.4178172840822203,1.641034754600386,1.1925938145223307,-0.6344483133432426,-0.971515740451046,0.07811250742307049,-1.1386163266404463,-0.5021316919187672,0.36847097049977656,1.8459424393187207,0.02805701137235168,0.3841256925736641,-0.558403728184664,1.4279535786684734,0.3841256925736641,-0.5208177336190014,0.19301386899346543,1.4534696782308594,1.2853737321434007,0.5833929390939195,3.391761695054266,3.2192694624153164,-0.22999085661134913,-0.02250118346835699,1.2853737321434007 3430 Hydrolase activity hydrolyzing o glycosyl compounds 12 23 3.5944270876953843 0.0003251061704865 P17900,O60476,Q9BTY2,P16278,P06865,P06280,O60502,P54802,P10253,P08236,Q9NUJ1,P04062 Functions GO Molecular function msigdb_gomf 66,227,202,43,268,275,147,87,311,279,221,30 977,227,147,30,895,275,268,1358,279,311,43,66,1224,87,741,1646,1202,551,2756,340,202,221,2712 0.33701658189477507,1.5916594876052144,1.904751655596212,3.0603364192521147,0.41529180787632924,1.4151493408700357,1.4279535786684734,0.09468784334280253,1.402314093228658,1.3246420617522143,2.9065277890482055,2.4918352621956807,0.17675834803240076,2.321161071650228,0.5833929390939195,-0.0564914375226667,0.19301386899346543,0.8041129767098191,-0.7116898323792509,1.2590315225380515,1.7142527679704935,1.6287336796515217,-0.6729168790091554 3430 Active ion transmembrane transporter activity 25 38 3.581395482733027 0.0003417638576324 P20020,P51798,Q7KZN9,P16615,O95202,P31930,Q9Y6M7,P00403,P12236,Q9HD20,Q96ES6,P08574,P06576,P23634,Q15043,Q02978,P55011,Q9UDW1,P13073,Q9BXP2,Q00325,P12235,P05023,P05141,P14854 Functions GO Molecular function msigdb_gomf 385,524,525,269,401,784,548,28,418,35,37,296,674,819,191,696,574,74,336,601,214,213,607,736,363 401,28,607,736,674,1567,296,840,213,418,336,363,269,385,1119,3191,3343,819,784,2149,2748,1075,524,1100,574,1259,214,696,191,525,37,601,1409,35,74,2136,2067,548 1.0981470112960925,3.0698107589013315,0.7169539114401163,0.5833929390939195,0.6431811538013191,-0.02250118346835699,1.3636206339195902,0.4616874064468927,1.641034754600386,1.057143066123191,1.2590315225380515,1.1925938145223307,1.4279535786684734,1.1388325289942267,0.24146991514915547,-1.2028041638743916,-1.7500104946959263,0.47705956297724367,0.522901157152449,-0.30111518243997987,-0.7116898323792509,0.2735187641595761,0.861414936766202,0.25751962221115077,0.7607169539788241,0.1604504658814682,1.641034754600386,0.6282990804246098,1.750489731196436,0.861414936766202,3.0222783212407616,0.7315827923762055,0.07811250742307049,3.0318170762153325,2.4178172840822203,-0.2832385860448953,-0.24767692023999524,0.8184979173823138 3430 Vacuole organization 13 53 3.5655794785391413 0.00036305311421 P42345,O14773,O75503,Q96GC9,P16615,Q8TBX8,P50897,P04062,P10253,Q8N511,P54802,Q14108,Q14457 Processes and pathways GO Biological process msigdb_gobp 353,162,104,188,269,242,22,30,311,25,87,60,287 2026,162,1186,104,1639,2285,1565,3286,30,1952,1358,311,370,269,353,1363,22,1364,87,2970,2186,2004,550,60,287,1488,1583,551,812,2052,730,902,25,242,1301,1624,188,2759,3158,2206,1466,1730,2400,1504,1050,2475,2875,1845,2315,1768,3222,2452,2317 -0.24767692023999524,1.8577557582221775,0.19301386899346543,2.189571052524327,-0.0564914375226667,-0.373271876429598,-0.02250118346835699,-1.4913543909405875,3.0603364192521147,-0.2123673195994045,0.09468784334280253,1.3246420617522143,1.179204988513675,1.4279535786684734,1.2192696206606266,0.09468784334280253,3.191546309151074,0.09468784334280253,2.321161071650228,-0.9103121062691136,-0.31905629408571334,-0.22999085661134913,0.8041129767098191,2.5336885717746562,1.3894476706931538,0.02805701137235168,-0.02250118346835699,0.8041129767098191,0.4923857069491886,-0.24767692023999524,0.5984052493734849,0.41529180787632924,3.1263237819839285,1.5418228550895896,0.14408985151272588,-0.03946755021715677,1.7625145060761207,-0.7116898323792509,-1.1386163266404463,-0.31905629408571334,0.04479749007284595,-0.0907134950668146,-0.4280869276823581,0.02805701137235168,0.30536674022651894,-0.4835161673691688,-0.8099892376198776,-0.1424888753229872,-0.373271876429598,-0.10791253841717666,-1.267862233870033,-0.4649705794159142,-0.373271876429598 3430 Vesicles 64 328 3.5597495010071323 0.0003712087116858 Q96K76,P24390,Q9NRY5,Q92564,P67809,O14734,O15460,Q13315,P06865,P35613,Q8IYR2,P50897,Q15907,Q8TAF3,Q14849,P21964,P08236,Q9NUD5,Q32P28,Q9HD20,Q96ES6,P07602,Q8WTV0,P16278,P30519,Q13595,Q9H2V7,Q9Y487,Q13277,Q9H8H2,A1L0T0,Q8TB61,P10253,P13674,Q9Y287,O60506,P17900,Q3SXM5,O15127,Q96L92,P05067,P42785,Q99519,O95302,Q9HD45,Q8NCC3,Q92791,Q93050,Q8NBX0,P42345,P10619,Q5BKZ1,P16435,Q6P4A7,Q9NPR9,P13473,O15118,Q86V85,Q96JB5,Q96SK2,Q9Y2G8,Q14534,O76062,O75153 Localization Protein Atlas Subcellular protein_atlas_subcellular_location_all 255,6,135,8,396,391,398,400,268,270,404,22,276,152,27,280,279,417,34,35,37,38,169,43,44,301,46,175,427,178,54,55,311,314,190,187,66,67,72,330,205,207,340,333,90,91,219,220,95,353,226,355,231,232,107,237,109,245,373,374,248,122,382,127 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3430 Endoplasmic reticulum lumen 27 61 3.5575783105808703 0.0003742895366938 Q14257,O15460,Q6P179,Q32P28,O14975,P14625,Q9NWM8,O43681,O95881,Q9Y680,Q9NZ08,P13674,Q969H8,O43852,Q9BTY2,P05067,O75718,Q13438,O00584,P27824,Q9UBS4,O76024,Q96AY3,O60568,Q08431,Q02818,Q07065 Localization GO Cellular component msigdb_gocc 133,398,407,34,424,300,179,553,436,56,185,314,716,321,202,205,89,596,467,725,750,477,357,376,503,246,253 467,2816,424,398,553,321,376,89,477,436,205,1284,1953,3162,1255,2323,314,1536,300,983,2619,3328,3048,3064,725,2800,1959,2641,965,2002,246,253,503,1335,596,133,1202,2236,1373,34,1375,407,1723,1621,1153,1266,2055,827,716,357,1499,1628,1087,202,179,1556,185,750,761,2405,56 0.9462000577616902,-0.7704316844994457,1.04340337414266,1.1117439633053623,0.7896879996375533,1.2853737321434007,1.1657819605638418,2.2994483251380298,0.9321647887240839,1.0158151806848401,1.6777690135569574,0.14408985151272588,-0.2123673195994045,-1.1599171531024435,0.1604504658814682,-0.3914762369552328,1.311585046538852,-0.005591913085313469,1.3506596827179598,0.33701658189477507,-0.6153265492951593,-1.6543045466896755,-0.992089953515064,-1.0127520150653435,0.5984052493734849,-0.7507725016906376,-0.2123673195994045,-0.6344483133432426,0.3527680424371989,-0.22999085661134913,1.5167285531774126,1.4915153034770001,0.8898304908049921,0.11120892157867891,0.7315827923762055,2.0204818903795823,0.19301386899346543,-0.33706243340680064,0.09468784334280253,3.0318170762153325,0.09468784334280253,1.0845146796370766,-0.0907134950668146,-0.03946755021715677,0.22536929144369766,0.1604504658814682,-0.24767692023999524,0.47705956297724367,0.6133738705970863,1.2192696206606266,0.02805701137235168,-0.03946755021715677,0.2735187641595761,1.7142527679704935,1.798428045397234,-0.005591913085313469,1.774512395985724,0.5833929390939195,0.5683366593475094,-0.4280869276823581,2.606176282501621 3430 Hydrolase activity acting on glycosyl bonds 13 30 3.5352855714385742 0.0004073346899517 P17900,O60476,Q9BTY2,P16278,O75503,P06865,P06280,O60502,P54802,P10253,P08236,Q9NUJ1,P04062 Functions GO Molecular function msigdb_gomf 66,227,202,43,104,268,275,147,87,311,279,221,30 977,2797,227,147,104,30,895,275,268,1358,279,311,2856,2549,43,66,2771,774,1224,87,741,1646,1202,551,2957,2756,340,202,221,2712 0.33701658189477507,-0.7507725016906376,1.5916594876052144,1.904751655596212,2.189571052524327,3.0603364192521147,0.41529180787632924,1.4151493408700357,1.4279535786684734,0.09468784334280253,1.402314093228658,1.3246420617522143,-0.8099892376198776,-0.558403728184664,2.9065277890482055,2.4918352621956807,-0.7311921139115007,0.5380910558331444,0.17675834803240076,2.321161071650228,0.5833929390939195,-0.0564914375226667,0.19301386899346543,0.8041129767098191,-0.8900812583352817,-0.7116898323792509,1.2590315225380515,1.7142527679704935,1.6287336796515217,-0.6729168790091554 3430 Peptide binding 22 80 3.528975114789011 0.0004171723573542 P24390,Q9UIQ6,P10321,O00264,Q15392,O14773,Q8WTV0,Q9NZ08,Q9Y287,P42892,O60684,Q92973,Q03519,Q03518,Q9BYT8,O43731,Q9NQX7,P55899,P01889,P04439,P52294,Q9Y584 Functions GO Molecular function msigdb_gomf 6,137,393,143,23,162,169,185,190,69,198,208,215,218,349,97,225,111,369,244,117,119 1848,143,1248,1908,1116,2796,162,2348,1635,926,2921,97,198,1098,369,244,1285,3126,3233,393,2148,2353,3328,6,3064,2640,2598,1317,965,657,2642,739,69,2952,3282,1915,862,2079,966,117,1033,575,111,2862,1014,2702,2804,218,215,3194,1578,2839,1922,2704,1372,3183,900,23,407,970,169,208,1460,1270,2166,1085,2912,349,849,474,225,1277,185,1053,2571,137,3079,190,3043,119 -0.15986707294579158,1.9513415899455118,0.1604504658814682,-0.1948058268211105,0.24146991514915547,-0.7507725016906376,1.8577557582221775,-0.40974773902190176,-0.0564914375226667,0.3841256925736641,-0.8699343008139493,2.233787760016152,1.7263589960332117,0.25751962221115077,1.179204988513675,1.5292904957224467,0.14408985151272588,-1.096295452188383,-1.3117306703903504,1.125305736257329,-0.30111518243997987,-0.40974773902190176,-1.6543045466896755,3.713359366894026,-1.0127520150653435,-0.6344483133432426,-0.596278947334594,0.1276761298241045,0.3527680424371989,0.65802036299361,-0.6344483133432426,0.5833929390939195,2.4496613605694386,-0.8900812583352817,-1.468526945815869,-0.1948058268211105,0.44626893355334946,-0.26542599868242417,0.3527680424371989,2.1113172784145564,0.30536674022651894,0.7607169539788241,2.1784605959005607,-0.8099892376198776,0.32121625895525563,-0.6729168790091554,-0.7507725016906376,1.6287336796515217,1.641034754600386,-1.2028041638743916,-0.02250118346835699,-0.7901703605422196,-0.1948058268211105,-0.6729168790091554,0.09468784334280253,-1.1813127889529935,0.41529180787632924,3.1543688124281597,1.0845146796370766,0.3527680424371989,1.8459424393187207,1.6777690135569574,0.04479749007284595,0.1604504658814682,-0.30111518243997987,0.2735187641595761,-0.8498704751461239,1.2458108826688405,0.4616874064468927,0.9462000577616902,1.6164042064007391,0.1604504658814682,1.774512395985724,0.30536674022651894,-0.558403728184664,1.9975331678372859,-1.0127520150653435,1.7625145060761207,-0.971515740451046,2.1113172784145564 3430 Glycoprotein biosynthetic process 25 55 3.525035649695188 0.0004234258041038 Q7LGA3,O14734,O60512,O60502,Q9H0U3,Q2TAA5,Q16706,Q8N4A0,P46977,Q9Y287,Q86YN1,Q10472,Q9UL01,Q96L58,Q9NQX7,Q92542,O60476,O60762,Q6ZXV5,Q9BT22,P04844,O15118,Q8NAT1,P35610,O60568 Processes and pathways GO Biological process msigdb_gobp 128,391,18,147,536,288,551,172,430,190,453,456,79,339,225,612,227,605,233,494,362,109,115,252,376 2107,391,109,2767,752,837,227,147,18,376,2546,605,2220,1356,2743,872,362,1190,252,2228,430,2836,2484,1296,2608,914,875,456,1646,1484,551,288,233,128,1723,453,172,115,628,612,2849,339,494,536,1138,748,3424,850,225,1246,1556,2687,79,190,1698 -0.2832385860448953,1.125305736257329,2.1784605959005607,-0.7311921139115007,0.5683366593475094,0.4616874064468927,1.5916594876052144,1.904751655596212,3.237676205824806,1.1657819605638418,-0.558403728184664,0.7169539114401163,-0.33706243340680064,0.09468784334280253,-0.7116898323792509,0.43080383738421585,1.1925938145223307,0.19301386899346543,1.4915153034770001,-0.33706243340680064,1.0296274822176772,-0.7901703605422196,-0.5021316919187672,0.14408985151272588,-0.596278947334594,0.3997325317718629,0.43080383738421585,0.9741576934609325,-0.0564914375226667,0.02805701137235168,0.8041129767098191,1.3894476706931538,1.5792439505261,2.0547236877093185,-0.0907134950668146,0.98808050071691,1.8341031346457968,2.156171440265243,0.7022834886797121,0.7169539114401163,-0.7901703605422196,1.2590315225380515,0.9180915884762,0.8328430643605732,0.24146991514915547,0.5833929390939195,-4.1411192303358,0.4616874064468927,1.6164042064007391,0.17675834803240076,-0.005591913085313469,-0.6536448751928122,2.3750691920218543,1.7625145060761207,-0.07357327446040215 3430 Protein targeting to mitochondrion 16 46 3.4982384098727923 0.0004683422728035 P30536,Q99797,Q9Y5J9,Q10713,O14737,Q8TB36,Q9NS69,Q8N4H5,O14925,Q99595,O60830,Q9Y512,Q5JRX3,Q9Y584,Q9Y5L4,Q9P0J0 Processes and pathways GO Biological process msigdb_gobp 2,290,193,292,165,390,7,101,204,78,20,278,85,119,125,158 2173,165,204,565,20,1532,1098,2898,803,3286,414,1443,656,3180,2260,2,3218,677,2040,694,575,2673,292,900,3016,968,951,85,1795,101,390,885,78,290,889,1867,7,158,3307,1114,3222,278,119,571,193,125 -0.31905629408571334,1.8459424393187207,1.6777690135569574,0.7752227411673067,3.2100435371001237,-0.005591913085313469,0.25751962221115077,-0.8498704751461239,0.4923857069491886,-1.4913543909405875,1.07084676596474,0.04479749007284595,0.65802036299361,-1.1813127889529935,-0.35513411913799386,3.92901774642917,-1.267862233870033,0.6431811538013191,-0.24767692023999524,0.6282990804246098,0.7607169539788241,-0.6536448751928122,1.3765499068522848,0.41529180787632924,-0.9510285615071858,0.3527680424371989,0.36847097049977656,2.3319852246797077,-0.12517084870498654,2.211724229893288,1.1388325289942267,0.43080383738421585,2.3750691920218543,1.3894476706931538,0.43080383738421585,-0.15986707294579158,3.602417135580486,1.8813049364421908,-1.5373416114687155,0.25751962221115077,-1.267862233870033,1.4151493408700357,2.1113172784145564,0.7752227411673067,1.750489731196436,2.066089721766653 3430 Tetrapyrrole binding 14 18 3.492956251019408 0.0004777047649382 Q8WUJ1,O15173,P53701,P08574,P30519,O43169,O00264,Q9Y5Z4,Q16850,Q9H7Z7,Q99707,Q96EY8,P09601,Q6UW02 Functions GO Molecular function msigdb_gomf 129,99,167,296,44,14,143,50,210,474,284,442,59,384 143,99,14,296,59,1665,44,167,210,384,525,129,442,284,474,1501,3043,50 1.9513415899455118,2.211724229893288,3.3468758304359083,1.3636206339195902,2.54410242985927,-0.07357327446040215,2.8378826071016987,1.8459424393187207,1.6655522802639968,1.1523245386286525,0.861414936766202,2.0547236877093185,1.0158151806848401,1.402314093228658,0.9462000577616902,0.02805701137235168,-0.971515740451046,2.68787200548125 3430 oxidoreductase 19 43 3.4926287267883707 0.0004782910032201 P51970,O43169,Q8N0U8,O95168,O43676,Q6DKJ4,Q16134,O14949,O15254,P00403,O95831,O75306,Q86Y39,Q15067,Q9Y6M9,P16435,O96000,Q8N4Q0,Q08431 Functions Panther Protein class panther_protein_class 386,14,17,529,21,406,533,155,285,28,414,413,168,319,326,231,606,492,503 892,1950,155,285,14,1311,21,2922,413,978,529,3008,414,606,28,3161,1568,3028,231,1997,1998,2356,3168,2359,3152,386,1513,2268,503,2297,319,533,3131,1673,1971,406,168,17,492,1499,1837,642,326 0.41529180787632924,-0.2123673195994045,1.8813049364421908,1.3894476706931538,3.3468758304359083,0.1276761298241045,3.200802504118346,-0.8699343008139493,1.07084676596474,0.33701658189477507,0.8471486580863727,-0.9510285615071858,1.07084676596474,0.7169539114401163,3.0698107589013315,-1.1599171531024435,-0.02250118346835699,-0.971515740451046,1.5792439505261,-0.22999085661134913,-0.22999085661134913,-0.40974773902190176,-1.1599171531024435,-0.40974773902190176,-1.1386163266404463,1.1388325289942267,0.01126068031324202,-0.35513411913799386,0.8898304908049921,-0.373271876429598,1.2984956621256847,0.8328430643605732,-1.096295452188383,-0.07357327446040215,-0.2123673195994045,1.0845146796370766,1.8459424393187207,3.256023162941908,0.9180915884762,0.02805701137235168,-0.1424888753229872,0.6875712647067221,1.2853737321434007 3430 Protein localization to mitochondrion 22 59 3.490734624127445 0.0004816944556416 P30536,P52789,Q8TB36,Q9NS69,Q9Y6C9,O60830,Q9Y512,Q9P0J0,O95831,Q99797,Q10713,O14737,Q15070,Q9Y5J7,O43615,Q9Y5J9,O14925,Q99595,Q5JRX3,Q8N4H5,Q9Y584,Q9Y5L4 Processes and pathways GO Biological process msigdb_gobp 2,510,390,7,145,20,278,158,414,290,292,165,181,571,565,193,204,78,85,101,119,125 2173,2026,1559,165,204,565,20,1532,1098,2898,803,3286,414,1443,656,2965,3180,982,1880,2260,2505,2,1999,3218,677,2040,694,510,575,2673,988,292,181,900,3016,968,951,85,1795,101,390,1236,885,78,290,889,1867,7,158,3307,1114,1350,3222,278,119,571,193,125,145 -0.31905629408571334,-0.24767692023999524,-0.02250118346835699,1.8459424393187207,1.6777690135569574,0.7752227411673067,3.2100435371001237,-0.005591913085313469,0.25751962221115077,-0.8498704751461239,0.4923857069491886,-1.4913543909405875,1.07084676596474,0.04479749007284595,0.65802036299361,-0.9103121062691136,-1.1813127889529935,0.33701658189477507,-0.1773059016141884,-0.35513411913799386,-0.5208177336190014,3.92901774642917,-0.22999085661134913,-1.267862233870033,0.6431811538013191,-0.24767692023999524,0.6282990804246098,0.8756421363992508,0.7607169539788241,-0.6536448751928122,0.33701658189477507,1.3765499068522848,1.7864835322979642,0.41529180787632924,-0.9510285615071858,0.3527680424371989,0.36847097049977656,2.3319852246797077,-0.12517084870498654,2.211724229893288,1.1388325289942267,0.17675834803240076,0.43080383738421585,2.3750691920218543,1.3894476706931538,0.43080383738421585,-0.15986707294579158,3.602417135580486,1.8813049364421908,-1.5373416114687155,0.25751962221115077,0.11120892157867891,-1.267862233870033,1.4151493408700357,2.1113172784145564,0.7752227411673067,1.750489731196436,2.066089721766653,1.9397317456196084 3430 Intrinsic component of mitochondrial membrane 22 43 3.486659448875019 0.0004890937297539 Q8TB36,Q9Y2R0,O60830,Q9Y512,Q16134,Q96NB2,Q9H9P8,Q15070,Q13505,Q6UXV4,O14925,Q99595,Q9NX63,Q00325,P12235,Q9NVH1,Q9UG56,Q9BUR5,Q16891,Q6P4A7,P57105,Q5XKP0 Localization GO Cellular component msigdb_gocc 390,19,20,278,533,410,688,181,58,697,204,78,732,214,213,616,487,613,479,232,238,626 204,1142,20,1010,1029,1098,839,1443,213,3050,1163,1058,238,214,58,181,900,533,479,951,626,232,697,756,1521,997,1130,390,410,78,613,887,3002,942,688,2445,616,732,487,3398,19,1025,278 1.6777690135569574,0.22536929144369766,3.2100435371001237,0.32121625895525563,0.30536674022651894,0.25751962221115077,0.4616874064468927,0.04479749007284595,1.641034754600386,-0.992089953515064,0.20921739577808898,0.2894676887918951,1.554325783520826,1.641034754600386,2.5544966637542177,1.7864835322979642,0.41529180787632924,0.8328430643605732,0.9321647887240839,0.36847097049977656,0.7022834886797121,1.5792439505261,0.6282990804246098,0.5683366593475094,0.01126068031324202,0.33701658189477507,0.24146991514915547,1.1388325289942267,1.0845146796370766,2.3750691920218543,0.7169539114401163,0.43080383738421585,-0.9306276139125141,0.3841256925736641,0.6431811538013191,-0.4649705794159142,0.7169539114401163,0.5984052493734849,0.9321647887240839,-2.2874512966961964,3.2192694624153164,0.32121625895525563,1.4151493408700357 3430 Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 14 34 3.478087886703888 0.0005050043178831 Q32P28,Q9NVH6,Q14534,P16435,Q15800,P30519,O15460,Q16850,O75845,Q8NB78,P13674,P09601,O60568,Q6UW02 Functions GO Molecular function msigdb_gomf 34,197,122,231,88,44,398,210,470,184,314,59,376,384 2107,644,398,2663,376,1636,782,470,554,1284,59,314,231,841,44,2266,1296,2087,122,88,210,34,2754,1650,384,2787,2653,1547,2885,184,473,1942,197,2591 -0.2832385860448953,0.6728169776242082,1.1117439633053623,-0.6536448751928122,1.1657819605638418,-0.0564914375226667,0.522901157152449,0.9462000577616902,0.7896879996375533,0.14408985151272588,2.54410242985927,1.311585046538852,1.5792439505261,0.4616874064468927,2.8378826071016987,-0.35513411913799386,0.14408985151272588,-0.26542599868242417,2.077431989617715,2.310315469590055,1.6655522802639968,3.0318170762153325,-0.7116898323792509,-0.0564914375226667,1.1523245386286525,-0.7311921139115007,-0.6344483133432426,-0.005591913085313469,-0.8298890333091614,1.774512395985724,0.9462000577616902,-0.1948058268211105,1.738437938975464,-0.5773048800496771 3430 Optic disc pallor 20 50 3.476971496523278 0.0005071117254513 Q9H061,Q96CU9,P51798,Q92974,O43676,O95831,O75306,Q10713,Q86Y39,Q13277,Q9Y287,Q9Y6M9,Q9NPL8,P03886,Q96L58,Q6P4Q7,Q9UG56,O96000,P04439,O60313 Drugs and Diseases Human Phenotype Ontology msigdb_hp 12,274,524,526,21,414,413,292,168,427,190,326,325,73,339,598,487,606,244,375 892,1559,977,2816,604,1328,21,961,375,1441,413,978,1532,1442,1638,414,606,73,244,2878,1880,2639,3031,3152,524,3360,292,427,598,1171,168,1681,1493,998,935,2057,526,274,339,792,2518,1212,12,1136,325,749,487,190,1025,326 0.41529180787632924,-0.02250118346835699,0.33701658189477507,-0.7704316844994457,0.7169539114401163,0.11120892157867891,3.200802504118346,0.3527680424371989,1.1657819605638418,0.04479749007284595,1.07084676596474,0.33701658189477507,-0.005591913085313469,0.04479749007284595,-0.0564914375226667,1.07084676596474,0.7169539114401163,2.4178172840822203,1.5292904957224467,-0.8298890333091614,-0.1773059016141884,-0.6344483133432426,-0.971515740451046,-1.1386163266404463,0.861414936766202,-1.8477085071425041,1.3765499068522848,1.04340337414266,0.7315827923762055,0.20921739577808898,1.8459424393187207,-0.07357327446040215,0.02805701137235168,0.33701658189477507,0.3841256925736641,-0.24767692023999524,0.861414936766202,1.4279535786684734,1.2590315225380515,0.522901157152449,-0.5208177336190014,0.19301386899346543,3.4362955117330025,0.24146991514915547,1.2853737321434007,0.5833929390939195,0.9321647887240839,1.7625145060761207,0.32121625895525563,1.2853737321434007 3430 Steroid binding 16 23 3.475776712353127 0.0005093761976049 P30536,O15173,Q9BZF1,P61916,P38435,P21796,Q96SU4,O00264,P45880,O15118,P35610,P22059,O75477,Q14849,Q14108,P04062 Functions GO Molecular function msigdb_gomf 2,99,458,512,136,9,564,143,15,109,252,316,566,27,60,30 143,109,99,566,2070,30,607,2146,9,316,2261,2,252,136,15,512,60,27,564,1591,1553,458,3380 1.9513415899455118,2.1784605959005607,2.211724229893288,0.7752227411673067,-0.26542599868242417,3.0603364192521147,0.7169539114401163,-0.30111518243997987,3.489279818123242,1.2984956621256847,-0.35513411913799386,3.92901774642917,1.4915153034770001,1.9975331678372859,3.2925394092933984,0.8756421363992508,2.5336885717746562,3.0792691433168833,0.7896879996375533,-0.02250118346835699,-0.005591913085313469,0.9741576934609325,-2.049460345691425 3430 Protein targeting 38 118 3.4701070608746143 0.0005202509489927 P46379,P30536,Q8TB36,Q9NS69,O00560,O60830,Q9Y512,Q9UGP8,Q9P0J0,O95831,Q99797,P43307,O14737,Q10713,Q7Z3B4,O43681,Q9Y5J7,Q14108,O43615,O60725,Q9Y5J9,P55786,O14925,Q99595,Q5JRX3,Q99523,Q13438,Q16543,Q8N4H5,Q96RL7,P46934,Q9Y5M8,P13473,P57105,Q9NQG6,Q15629,Q9Y584,Q9Y5L4 Processes and pathways GO Biological process msigdb_gobp 256,2,390,7,266,20,278,547,158,414,290,36,165,292,559,553,571,60,565,65,193,575,204,78,85,600,596,229,101,358,103,236,237,238,499,116,119,125 1737,2173,2026,266,2347,165,204,907,565,553,1809,65,20,1056,1532,2069,1098,2898,803,3286,414,1443,656,1508,3180,2108,237,2260,1147,2458,3217,774,2,3293,2774,3218,2642,739,36,256,103,677,2184,2040,2079,1364,694,575,238,3390,2930,2862,1014,3034,2555,2902,2645,2673,2464,292,1716,1422,596,60,877,713,900,116,3016,229,968,951,85,2335,2393,1586,559,2868,1795,2275,2160,2678,101,390,2468,358,2760,793,885,600,1272,78,290,1839,889,3003,1867,499,7,2400,158,3307,547,1053,2687,1114,1386,1845,3042,617,3222,2404,278,119,571,193,125,236 -0.10791253841717666,-0.31905629408571334,-0.24767692023999524,1.4407269703301229,-0.40974773902190176,1.8459424393187207,1.6777690135569574,0.3997325317718629,0.7752227411673067,0.7896879996375533,-0.1424888753229872,2.4918352621956807,3.2100435371001237,0.2894676887918951,-0.005591913085313469,-0.26542599868242417,0.25751962221115077,-0.8498704751461239,0.4923857069491886,-1.4913543909405875,1.07084676596474,0.04479749007284595,0.65802036299361,0.01126068031324202,-1.1813127889529935,-0.2832385860448953,1.554325783520826,-0.35513411913799386,0.22536929144369766,-0.4835161673691688,-1.267862233870033,0.5380910558331444,3.92901774642917,-1.5142922206614813,-0.7311921139115007,-1.267862233870033,-0.6344483133432426,0.5833929390939195,3.0222783212407616,1.47886368568901,2.2006588969869694,0.6431811538013191,-0.31905629408571334,-0.24767692023999524,-0.26542599868242417,0.09468784334280253,0.6282990804246098,0.7607169539788241,1.554325783520826,-2.153721952328721,-0.8699343008139493,-0.8099892376198776,0.32121625895525563,-0.971515740451046,-0.558403728184664,-0.8498704751461239,-0.6344483133432426,-0.6536448751928122,-0.4835161673691688,1.3765499068522848,-0.0907134950668146,0.06148252180205109,0.7315827923762055,2.5336885717746562,0.43080383738421585,0.6133738705970863,0.41529180787632924,2.133790611209967,-0.9510285615071858,1.5916594876052144,0.3527680424371989,0.36847097049977656,2.3319852246797077,-0.3914762369552328,-0.4280869276823581,-0.02250118346835699,0.7896879996375533,-0.8099892376198776,-0.12517084870498654,-0.35513411913799386,-0.30111518243997987,-0.6536448751928122,2.211724229893288,1.1388325289942267,-0.4835161673691688,1.2192696206606266,-0.7116898323792509,0.522901157152449,0.43080383738421585,0.7315827923762055,0.1604504658814682,2.3750691920218543,1.3894476706931538,-0.1424888753229872,0.43080383738421585,-0.9306276139125141,-0.15986707294579158,0.903980231650309,3.602417135580486,-0.4280869276823581,1.8813049364421908,-1.5373416114687155,0.8184979173823138,0.30536674022651894,-0.6536448751928122,0.25751962221115077,0.09468784334280253,-0.1424888753229872,-0.971515740451046,0.7169539114401163,-1.267862233870033,-0.4280869276823581,1.4151493408700357,2.1113172784145564,0.7752227411673067,1.750489731196436,2.066089721766653,1.5667994320520733 3430 Increased serum lactate 28 107 3.465404645529462 0.0005294342344712 P51970,Q9NP80,Q96CU9,Q9UBX3,Q70HW3,O14949,P00403,Q9P0J0,O95831,O75306,Q99797,Q86Y39,P08574,Q9BWD1,Q9NWS8,Q9NVI7,Q9Y6M9,O75648,P03886,P13073,Q5JRX3,Q00325,P12235,Q9BW92,Q6P4A7,P14854,Q9Y584,P35610 Drugs and Diseases Human Phenotype Ontology msigdb_hp 386,264,274,13,16,155,28,158,414,413,290,168,296,304,182,443,326,444,73,336,85,214,213,485,232,363,119,252 892,1948,1559,1950,155,2922,1142,1441,413,1532,1442,444,1029,2033,414,1951,28,2224,73,1566,2035,296,723,1568,3415,213,336,363,3331,2639,1119,693,984,2354,3031,3011,1747,252,2926,804,2801,1395,2507,2602,3152,2509,386,2669,2483,1713,2462,1034,1576,1333,214,1450,1015,742,2995,1673,968,951,651,85,1262,810,680,626,2786,232,1104,16,525,1424,168,746,1493,3355,920,2565,1459,274,1865,937,1837,290,2518,485,304,1179,816,1660,1089,264,443,1091,182,2133,158,13,1350,488,2024,1531,119,1601,326 0.41529180787632924,-0.2123673195994045,-0.02250118346835699,-0.2123673195994045,1.8813049364421908,-0.8699343008139493,0.22536929144369766,0.04479749007284595,1.07084676596474,-0.005591913085313469,0.04479749007284595,1.001966258000303,0.30536674022651894,-0.24767692023999524,1.07084676596474,-0.2123673195994045,3.0698107589013315,-0.33706243340680064,2.4178172840822203,-0.02250118346835699,-0.24767692023999524,1.3636206339195902,0.5984052493734849,-0.02250118346835699,-3.285316956235847,1.641034754600386,1.2590315225380515,1.1925938145223307,-1.6780491319681583,-0.6344483133432426,0.24146991514915547,0.6282990804246098,0.33701658189477507,-0.40974773902190176,-0.971515740451046,-0.9510285615071858,-0.10791253841717666,1.4915153034770001,-0.8699343008139493,0.4923857069491886,-0.7507725016906376,0.07811250742307049,-0.5208177336190014,-0.596278947334594,-1.1386163266404463,-0.5208177336190014,1.1388325289942267,-0.6536448751928122,-0.5021316919187672,-0.0907134950668146,-0.4835161673691688,0.30536674022651894,-0.02250118346835699,0.11120892157867891,1.641034754600386,0.04479749007284595,0.32121625895525563,0.5833929390939195,-0.9306276139125141,-0.07357327446040215,0.3527680424371989,0.36847097049977656,0.6728169776242082,2.3319852246797077,0.1604504658814682,0.4923857069491886,0.6431811538013191,0.7022834886797121,-0.7311921139115007,1.5792439505261,0.25751962221115077,3.2651743542921823,0.861414936766202,0.06148252180205109,1.8459424393187207,0.5833929390939195,0.02805701137235168,-1.8230922651443087,0.3997325317718629,-0.558403728184664,0.04479749007284595,1.4279535786684734,-0.15986707294579158,0.3841256925736641,-0.1424888753229872,1.3894476706931538,-0.5208177336190014,0.9321647887240839,1.3506596827179598,0.20921739577808898,0.4923857069491886,-0.0564914375226667,0.2735187641595761,1.4534696782308594,1.0158151806848401,0.2735187641595761,1.7864835322979642,-0.2832385860448953,1.8813049364421908,3.391761695054266,0.11120892157867891,0.9321647887240839,-0.22999085661134913,0.01126068031324202,2.1113172784145564,-0.02250118346835699,1.2853737321434007 3430 Abnormal vascular physiology 17 56 3.4602546733310886 0.0005396647274031 O75844,P51970,O14678,P03886,P05067,P14854,P01889,Q14739,P06280,Q9NWM8,Q8IZA0,O60568,Q9Y4P3,Q9NZ08,Q14108,P00403,P04062 Drugs and Diseases Human Phenotype Ontology msigdb_hp 32,386,257,73,205,363,369,222,275,179,93,376,313,185,60,28,30 1389,257,398,2350,376,2145,3248,32,1390,606,28,369,1534,73,30,1877,205,275,1255,363,1956,1119,3127,2073,2925,3064,3066,1190,2775,2000,1541,796,1612,524,386,1290,2879,1296,60,3275,222,2299,680,822,953,2676,580,93,1624,2132,179,185,866,2025,313,3043 0.07811250742307049,1.4661818634308703,1.1117439633053623,-0.40974773902190176,1.1657819605638418,-0.30111518243997987,-1.3560056220962575,3.050846065270086,0.07811250742307049,0.7169539114401163,3.0698107589013315,1.179204988513675,-0.005591913085313469,2.4178172840822203,3.0603364192521147,-0.1773059016141884,1.6777690135569574,1.4151493408700357,0.1604504658814682,1.1925938145223307,-0.2123673195994045,0.24146991514915547,-1.096295452188383,-0.26542599868242417,-0.8699343008139493,-1.0127520150653435,-1.0127520150653435,0.19301386899346543,-0.7311921139115007,-0.22999085661134913,-0.005591913085313469,0.5076661391022604,-0.03946755021715677,0.861414936766202,1.1388325289942267,0.14408985151272588,-0.8298890333091614,0.14408985151272588,2.5336885717746562,-1.445808727840182,1.6164042064007391,-0.373271876429598,0.6431811538013191,0.47705956297724367,0.36847097049977656,-0.6536448751928122,0.7607169539788241,2.2667166943530197,-0.03946755021715677,-0.2832385860448953,1.798428045397234,1.774512395985724,0.44626893355334946,-0.22999085661134913,1.3246420617522143,-0.971515740451046 3430 Mitochondrial substrate/solute carrier [IPR018108] 17 20 3.4572099384186736 0.0005457994656994 Q6NUK1,O75746,P12236,Q02978,O43808,Q9UBX3,Q9Y619,Q9NZJ7,Q70HW3,Q9Y6C9,Q9H2D1,Q9UJS0,Q9BSK2,Q00325,O43772,Q9BQT8,P12235 Sequence InterPro Repeat interpro_repeat 580,692,418,696,573,13,45,341,16,145,49,708,61,214,468,157,213 468,573,692,736,213,418,1100,214,696,580,16,157,61,49,1409,341,13,708,45,145 0.9462000577616902,0.7607169539788241,0.6282990804246098,0.5833929390939195,1.641034754600386,1.057143066123191,0.25751962221115077,1.641034754600386,0.6282990804246098,0.7607169539788241,3.2651743542921823,1.8813049364421908,2.5336885717746562,2.7383268943293446,0.07811250742307049,1.2590315225380515,3.391761695054266,0.6282990804246098,2.7982738550861823,1.9397317456196084 3430 Mitochondrial carrier domain superfamily [IPR023395] 17 20 3.4572099384186736 0.0005457994656994 Q6NUK1,O75746,P12236,Q02978,O43808,Q9UBX3,Q9Y619,Q9NZJ7,Q70HW3,Q9Y6C9,Q9H2D1,Q9UJS0,Q9BSK2,Q00325,O43772,Q9BQT8,P12235 Sequence InterPro Superfamily interpro_homologous_superfamily 580,692,418,696,573,13,45,341,16,145,49,708,61,214,468,157,213 468,573,692,736,213,418,1100,214,696,580,16,157,61,49,1409,341,13,708,45,145 0.9462000577616902,0.7607169539788241,0.6282990804246098,0.5833929390939195,1.641034754600386,1.057143066123191,0.25751962221115077,1.641034754600386,0.6282990804246098,0.7607169539788241,3.2651743542921823,1.8813049364421908,2.5336885717746562,2.7383268943293446,0.07811250742307049,1.2590315225380515,3.391761695054266,0.6282990804246098,2.7982738550861823,1.9397317456196084 3430 SLC25 family of mitochondrial transporters 17 20 3.4572099384186736 0.0005457994656994 Q6NUK1,O75746,P12236,Q02978,O43808,Q9UBX3,Q9Y619,Q9NZJ7,Q70HW3,Q9Y6C9,Q9H2D1,Q9UJS0,Q9BSK2,Q00325,O43772,Q9BQT8,P12235 Drugs and Diseases Pharos Drug Target Ontology pharos_dto 580,692,418,696,573,13,45,341,16,145,49,708,61,214,468,157,213 468,573,692,736,213,418,1100,214,696,580,16,157,61,49,1409,341,13,708,45,145 0.9462000577616902,0.7607169539788241,0.6282990804246098,0.5833929390939195,1.641034754600386,1.057143066123191,0.25751962221115077,1.641034754600386,0.6282990804246098,0.7607169539788241,3.2651743542921823,1.8813049364421908,2.5336885717746562,2.7383268943293446,0.07811250742307049,1.2590315225380515,3.391761695054266,0.6282990804246098,2.7982738550861823,1.9397317456196084 3430 Abnormality of the cerebrospinal fluid 45 157 3.4541524211283656 0.0005520252860931 P51970,P51798,Q7KZN9,Q96CU9,O43676,O95202,Q15392,P21964,P08236,P00403,Q9P0J0,P04062,O95831,P23786,O75306,Q10713,Q12768,P07602,P53701,Q86Y39,O43681,Q9NWS8,Q15427,Q6NUK1,Q9Y6M9,Q9NPL8,P55011,P03886,O15360,Q9NZJ7,Q99519,Q96L58,P13073,O96028,Q16625,Q8TAA9,Q00839,O96000,P16435,P48651,Q9UBM7,P14854,Q8NAT1,Q9NR77,Q14738 Drugs and Diseases Human Phenotype Ontology msigdb_hp 386,524,525,274,21,401,23,280,279,28,158,30,414,33,413,292,550,38,167,168,553,182,312,580,326,325,574,73,454,341,340,339,336,334,346,482,609,606,231,360,632,363,115,123,254 1472,892,1948,1437,1950,977,1438,869,454,1774,752,21,2922,553,1142,1055,1097,1473,1441,413,2410,978,1442,3248,3149,2897,401,2033,414,606,334,28,73,30,1877,1284,38,1953,279,2035,1189,676,336,363,983,231,896,2639,1415,1446,3127,2073,280,33,1851,3031,2576,3011,795,1747,1813,1190,3068,2413,804,2078,739,2801,1395,1541,360,1543,862,3152,2509,524,386,2483,167,2670,574,1290,2780,2992,1333,609,1198,1015,2934,1227,2364,1297,292,2045,550,3296,2626,2113,254,2995,23,312,346,1673,810,822,580,1104,525,1424,994,168,1652,1493,2010,115,3355,920,482,935,2565,1237,2422,2338,1269,1176,1624,274,339,1865,885,340,1837,2518,1242,3121,1942,2735,640,850,3371,325,123,1502,2022,2375,1091,182,341,749,158,632,666,2025,3043,1698,326 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3430 Glycosidase 10 19 3.4513599429145887 0.0005577691624096 O60476,Q9BTY2,P16278,P06865,P06280,O60502,P54802,P10253,P08236,P04062 Functions Protein Atlas Molecular function protein_atlas_molecular_function 227,202,43,268,275,147,87,311,279,30 977,2797,227,147,30,895,275,268,1358,279,311,43,1224,87,1646,1202,551,340,202 0.33701658189477507,-0.7507725016906376,1.5916594876052144,1.904751655596212,3.0603364192521147,0.41529180787632924,1.4151493408700357,1.4279535786684734,0.09468784334280253,1.402314093228658,1.3246420617522143,2.9065277890482055,0.17675834803240076,2.321161071650228,-0.0564914375226667,0.19301386899346543,0.8041129767098191,1.2590315225380515,1.7142527679704935 3430 Abnormal esophagus physiology 52 233 3.4333598100960767 0.0005961504013742 O75874,O14678,P61916,P48735,Q13045,P51571,P06280,O95202,Q99720,P21964,Q9UGP8,P04062,O75306,O15269,Q12768,P07602,O15270,Q9Y619,Q9Y4P3,Q14108,Q96D71,Q15067,Q6NUK1,P04350,P42858,P55011,P55795,P03886,Q06787,P05067,P15586,Q9NZJ7,Q99519,Q96PU5,O96028,O75569,P12235,Q8IZA0,Q14739,O76024,Q96RL7,P16435,Q6ZXV5,P35637,O15118,P01889,Q9UHX1,Q9Y584,Q96A33,Q13510,Q9NR77,O60313 Drugs and Diseases Human Phenotype Ontology msigdb_hp 1,257,512,10,531,403,275,401,26,280,547,30,413,286,550,38,295,45,313,60,582,319,580,445,447,574,196,73,203,205,206,341,340,211,334,342,213,93,222,477,358,231,233,235,109,369,118,119,379,250,123,375 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3430 Endocytic vesicle membrane 11 40 3.431156066516371 0.0006010147186485 Q8WTV0,P10321,P13473,Q9Y487,P01889,Q93050,P04439,Q03519,Q15907,Q03518,Q14108 Localization GO Cellular component msigdb_gocc 169,393,237,175,369,220,244,215,276,218,60 926,1186,2071,1702,369,1314,244,393,646,1509,1994,237,1147,3064,1192,1364,1011,986,2644,1149,1259,2804,1783,1450,218,215,1578,1337,1669,60,1583,2237,276,449,169,220,1270,1272,2875,175 0.3841256925736641,0.19301386899346543,-0.26542599868242417,-0.0907134950668146,1.179204988513675,0.1276761298241045,1.5292904957224467,1.125305736257329,0.6728169776242082,0.01126068031324202,-0.22999085661134913,1.554325783520826,0.22536929144369766,-1.0127520150653435,0.19301386899346543,0.09468784334280253,0.32121625895525563,0.33701658189477507,-0.6344483133432426,0.22536929144369766,0.1604504658814682,-0.7507725016906376,-0.12517084870498654,0.04479749007284595,1.6287336796515217,1.641034754600386,-0.02250118346835699,0.11120892157867891,-0.07357327446040215,2.5336885717746562,-0.02250118346835699,-0.33706243340680064,1.4151493408700357,1.001966258000303,1.8459424393187207,1.6287336796515217,0.1604504658814682,0.1604504658814682,-0.8099892376198776,1.8103460646896083 3430 Membrane lipid biosynthetic process 15 22 3.4068367985823267 0.0006572041101968 Q06136,O15269,O43292,Q9P035,O60762,O15270,Q9NXE4,O60512,P27544,O95470,Q13510,P22059,Q96G23,P04062,Q8NBX0 Processes and pathways GO Biological process msigdb_gobp 258,286,194,294,605,295,591,18,501,86,250,316,124,30,95 286,295,194,18,605,86,30,316,501,2511,258,250,951,95,1083,1378,124,2761,640,591,294,1734 1.3894476706931538,1.3636206339195902,1.738437938975464,3.237676205824806,0.7169539114401163,2.321161071650228,3.0603364192521147,1.2984956621256847,0.8898304908049921,-0.5208177336190014,1.4661818634308703,1.5041368739934033,0.36847097049977656,2.244786155021276,0.2735187641595761,0.09468784334280253,2.066089721766653,-0.7116898323792509,0.6875712647067221,0.7461703883999292,1.3765499068522848,-0.0907134950668146 3430 Visual loss 15 52 3.403378459197383 0.000665580179531 O14773,Q10713,P07602,P53701,P03886,O75503,O15460,Q9NZJ7,Q99519,P14854,P01889,P04439,P50897,O60313,P00403 Drugs and Diseases Human Phenotype Ontology msigdb_hp 162,292,38,167,73,104,398,341,340,363,369,244,22,375,28 906,2406,2173,1559,162,869,398,375,413,1532,104,1187,28,3330,369,73,2855,244,38,2286,2431,363,1956,2073,2458,1190,3068,1710,948,753,22,1194,524,1120,167,1198,292,2045,3296,2046,2973,2995,1128,1175,1524,1176,1134,885,340,1837,1089,341 0.3997325317718629,-0.4464943548499513,-0.31905629408571334,-0.02250118346835699,1.8577557582221775,0.43080383738421585,1.1117439633053623,1.1657819605638418,1.07084676596474,-0.005591913085313469,2.189571052524327,0.19301386899346543,3.0698107589013315,-1.6780491319681583,1.179204988513675,2.4178172840822203,-0.8099892376198776,1.5292904957224467,3.0127233121243298,-0.373271876429598,-0.4649705794159142,1.1925938145223307,-0.2123673195994045,-0.26542599868242417,-0.4835161673691688,0.19301386899346543,-1.0127520150653435,-0.0907134950668146,0.36847097049977656,0.5683366593475094,3.191546309151074,0.19301386899346543,0.861414936766202,0.24146991514915547,1.8459424393187207,0.19301386899346543,1.3765499068522848,-0.24767692023999524,-1.5142922206614813,-0.24767692023999524,-0.9103121062691136,-0.9306276139125141,0.24146991514915547,0.20921739577808898,0.01126068031324202,0.20921739577808898,0.24146991514915547,0.43080383738421585,1.2590315225380515,-0.1424888753229872,0.2735187641595761,1.2590315225380515 3430 Cation transport 51 160 3.402966895980386 0.0006665835644663 Q99623,P30536,P20020,P21796,P24539,Q7KZN9,P16615,Q70HW3,Q13423,P30825,O95202,Q15907,Q9H0U3,Q96NB2,Q9Y6M7,P00403,O75844,Q9HD20,Q4KMQ2,Q96ES6,P33176,P08574,Q9Y619,O75964,Q96GC9,Q15043,P42858,P55011,O43808,Q99959,Q9UDW1,Q06787,P05067,P61586,P13073,Q96PU5,Q9BXP2,Q6P4Q7,Q00325,P12235,O43772,Q8IYU8,O43865,O15173,O76024,P05023,P46934,Q9HD47,O14936,P14854,Q9NUT2 Processes and pathways GO Biological process msigdb_gobp 517,2,385,9,138,525,269,16,146,402,401,276,536,410,548,28,32,35,163,37,425,296,45,47,188,191,447,574,573,586,74,203,205,337,336,211,601,598,214,213,468,347,469,99,477,607,103,106,604,363,519 1772,1559,1950,2816,604,99,781,468,573,469,2832,763,1441,2031,2693,1532,32,3081,47,477,401,1639,28,1314,1220,607,205,736,1607,963,674,1221,1952,3082,2146,1567,296,2965,840,2411,3301,213,336,3047,947,363,269,1444,2109,3303,1316,2504,385,1610,1119,3191,3343,3127,9,819,138,1570,2925,774,2640,2598,2,3166,402,784,2076,425,1190,3167,1257,2149,2748,447,2835,103,1396,1075,3379,1192,1011,1573,1574,574,2080,726,2042,1259,337,1014,2555,1121,1918,214,2464,1783,1577,2187,203,988,3253,3204,1716,146,1337,1669,1670,624,191,2237,950,276,1673,163,598,1039,16,525,2161,347,1863,1130,1236,882,37,188,1499,410,211,3387,517,1552,586,1590,601,536,2370,1409,942,35,106,3429,519,1092,74,2687,2136,1530,2250,668,2964,1632,2345,1025,45,548 -0.12517084870498654,-0.02250118346835699,-0.2123673195994045,-0.7704316844994457,0.7169539114401163,2.211724229893288,0.522901157152449,0.9462000577616902,0.7607169539788241,0.9462000577616902,-0.7901703605422196,0.5532361269354006,0.04479749007284595,-0.24767692023999524,-0.6729168790091554,-0.005591913085313469,3.050846065270086,-1.0335027512907717,2.748363067010926,0.9321647887240839,1.0981470112960925,-0.0564914375226667,3.0698107589013315,0.1276761298241045,0.17675834803240076,0.7169539114401163,1.6777690135569574,0.5833929390939195,-0.03946755021715677,0.3527680424371989,0.6431811538013191,0.17675834803240076,-0.2123673195994045,-1.0335027512907717,-0.30111518243997987,-0.02250118346835699,1.3636206339195902,-0.9103121062691136,0.4616874064468927,-0.4464943548499513,-1.5373416114687155,1.641034754600386,1.2590315225380515,-0.992089953515064,0.36847097049977656,1.1925938145223307,1.4279535786684734,0.04479749007284595,-0.2832385860448953,-1.5373416114687155,0.1276761298241045,-0.5208177336190014,1.1388325289942267,-0.03946755021715677,0.24146991514915547,-1.2028041638743916,-1.7500104946959263,-1.096295452188383,3.489279818123242,0.47705956297724367,1.9744867066455778,-0.02250118346835699,-0.8699343008139493,0.5380910558331444,-0.6344483133432426,-0.596278947334594,3.92901774642917,-1.1599171531024435,1.0981470112960925,0.522901157152449,-0.26542599868242417,1.04340337414266,0.19301386899346543,-1.1599171531024435,0.1604504658814682,-0.30111518243997987,-0.7116898323792509,1.001966258000303,-0.7901703605422196,2.2006588969869694,0.07811250742307049,0.2735187641595761,-2.0237575733036444,0.19301386899346543,0.32121625895525563,-0.02250118346835699,-0.02250118346835699,0.7607169539788241,-0.26542599868242417,0.5984052493734849,-0.24767692023999524,0.1604504658814682,1.2590315225380515,0.32121625895525563,-0.558403728184664,0.24146991514915547,-0.1948058268211105,1.641034754600386,-0.4835161673691688,-0.12517084870498654,-0.02250118346835699,-0.31905629408571334,1.7021191193583658,0.33701658189477507,-1.3560056220962575,-1.2243922216969028,-0.0907134950668146,1.9280968875332776,0.11120892157867891,-0.07357327446040215,-0.07357327446040215,0.7022834886797121,1.750489731196436,-0.33706243340680064,0.36847097049977656,1.4151493408700357,-0.07357327446040215,1.8577557582221775,0.7315827923762055,0.30536674022651894,3.2651743542921823,0.861414936766202,-0.30111518243997987,1.2458108826688405,-0.15986707294579158,0.24146991514915547,0.17675834803240076,0.43080383738421585,3.0222783212407616,1.7625145060761207,0.02805701137235168,1.0845146796370766,1.6655522802639968,-2.1012974711813244,0.8756421363992508,-0.005591913085313469,0.7461703883999292,-0.02250118346835699,0.7315827923762055,0.8328430643605732,-0.40974773902190176,0.07811250742307049,0.3841256925736641,3.0318170762153325,2.189571052524327,-11.531405437931214,0.8756421363992508,0.2735187641595761,2.4178172840822203,-0.6536448751928122,-0.2832385860448953,0.01126068031324202,-0.33706243340680064,0.65802036299361,-0.8900812583352817,-0.03946755021715677,-0.3914762369552328,0.32121625895525563,2.7982738550861823,0.8184979173823138 3430 Abnormal heart valve morphology 26 82 3.3906019016941435 0.0006973932273699 P61978,P51798,P06280,O95202,Q6DKJ4,P21964,P08236,P04062,O75844,Q12768,P37268,P53701,P16278,Q9Y4P3,P55795,Q06787,O15360,Q9UL01,Q96L58,Q96PU5,O96028,Q6PGP7,Q6ZXV5,P01889,Q9UHX1,Q14738 Drugs and Diseases Human Phenotype Ontology msigdb_hp 387,524,275,401,406,280,279,30,32,550,166,167,43,313,196,203,454,79,339,211,334,480,233,369,118,254 1472,1160,1438,2767,454,3060,2350,837,1161,1473,1010,32,1777,401,334,369,1534,858,30,275,2819,279,2431,1189,43,3127,2073,280,3163,2800,3066,2775,2413,2149,166,2078,2668,2749,524,619,167,2670,821,196,2083,387,2043,1331,2879,1198,2934,1296,2556,203,550,2626,1202,254,2299,1078,2439,406,580,480,233,2729,2422,339,211,2312,1242,3371,2022,2102,1092,750,2737,118,866,79,2066,313 0.02805701137235168,0.20921739577808898,0.04479749007284595,-0.7311921139115007,0.9741576934609325,-1.0127520150653435,-0.40974773902190176,0.4616874064468927,0.20921739577808898,0.02805701137235168,0.32121625895525563,3.050846065270086,-0.12517084870498654,1.0981470112960925,1.2590315225380515,1.179204988513675,-0.005591913085313469,0.44626893355334946,3.0603364192521147,1.4151493408700357,-0.7704316844994457,1.402314093228658,-0.4649705794159142,0.19301386899346543,2.9065277890482055,-1.096295452188383,-0.26542599868242417,1.402314093228658,-1.1599171531024435,-0.7507725016906376,-1.0127520150653435,-0.7311921139115007,-0.4464943548499513,-0.30111518243997987,1.8459424393187207,-0.26542599868242417,-0.6536448751928122,-0.7116898323792509,0.861414936766202,0.7022834886797121,1.8459424393187207,-0.6536448751928122,0.47705956297724367,1.738437938975464,-0.26542599868242417,1.1388325289942267,-0.24767692023999524,0.11120892157867891,-0.8298890333091614,0.19301386899346543,-0.8699343008139493,0.14408985151272588,-0.558403728184664,1.7021191193583658,0.8041129767098191,-0.6153265492951593,0.19301386899346543,1.4915153034770001,-0.373271876429598,0.2735187641595761,-0.4649705794159142,1.0845146796370766,0.7607169539788241,0.9321647887240839,1.5792439505261,-0.6922649775615227,-0.4464943548499513,1.2590315225380515,1.6655522802639968,-0.373271876429598,0.17675834803240076,-1.9474917631058593,-0.22999085661134913,-0.26542599868242417,0.2735187641595761,0.5833929390939195,-0.6922649775615227,2.1113172784145564,0.44626893355334946,2.3750691920218543,-0.24767692023999524,1.3246420617522143 3430 Azurophil granule 26 70 3.378595147720921 0.0007285721548262 P61916,O00560,P06865,P06280,Q9H0U3,P08236,P07602,Q13277,P16278,Q92820,Q9Y5Z4,P10253,P07437,P17900,Q9BTY2,Q9NZJ7,P15586,P42785,Q9H7Z7,O00584,Q9NQX7,P10619,O15260,P13473,Q8NF37,Q07065 Localization GO Cellular component msigdb_gocc 512,266,268,275,536,279,38,427,43,433,50,311,310,66,202,341,206,207,474,467,225,226,98,237,506,253 266,467,977,98,1071,553,1355,2455,870,1876,895,275,268,1952,310,38,1358,279,311,226,1955,646,237,983,206,43,66,2800,3344,2228,207,2928,3270,912,2461,1011,1855,3105,2387,2463,512,787,1644,2648,3107,2511,253,1335,427,2298,812,2055,506,612,433,3075,1155,3109,1938,2887,1304,202,536,474,225,3021,341,1734,2740,50 1.4407269703301229,0.9462000577616902,0.33701658189477507,2.2227671511588163,0.2735187641595761,0.7896879996375533,0.09468784334280253,-0.4835161673691688,0.43080383738421585,-0.1773059016141884,0.41529180787632924,1.4151493408700357,1.4279535786684734,-0.2123673195994045,1.3246420617522143,3.0127233121243298,0.09468784334280253,1.402314093228658,1.3246420617522143,1.6040461907838122,-0.2123673195994045,0.6728169776242082,1.554325783520826,0.33701658189477507,1.6777690135569574,2.9065277890482055,2.4918352621956807,-0.7507725016906376,-1.7500104946959263,-0.33706243340680064,1.6777690135569574,-0.8699343008139493,-1.4231985981949864,0.3997325317718629,-0.4835161673691688,0.32121625895525563,-0.15986707294579158,-1.0543430004362901,-0.4280869276823581,-0.4835161673691688,0.8756421363992508,0.522901157152449,-0.0564914375226667,-0.6344483133432426,-1.0543430004362901,-0.5208177336190014,1.4915153034770001,0.11120892157867891,1.04340337414266,-0.373271876429598,0.4923857069491886,-0.24767692023999524,0.8898304908049921,0.7169539114401163,1.0296274822176772,-1.0127520150653435,0.22536929144369766,-1.0543430004362901,-0.1948058268211105,-0.8298890333091614,0.14408985151272588,1.7142527679704935,0.8328430643605732,0.9462000577616902,1.6164042064007391,-0.9510285615071858,1.2590315225380515,-0.0907134950668146,-0.6922649775615227,2.68787200548125 3430 Primary active transmembrane transporter activity 26 56 3.3773541918671297 0.0007318674313674 P20020,P51970,O14678,P51798,Q7KZN9,P16615,O95168,O43676,P00403,Q9P0J0,O75306,P08183,Q9HD20,P08574,P06576,P28288,Q9Y6M9,P03886,Q9UDW1,P13073,Q03519,Q03518,P05023,O96000,P14854,Q9NUT2 Functions GO Molecular function msigdb_gomf 385,386,257,524,525,269,529,21,28,158,413,159,35,296,674,555,326,73,74,336,215,218,607,606,363,519 892,1950,257,926,21,2922,763,1441,413,978,671,1442,529,3008,2033,606,28,73,607,674,159,296,840,336,363,269,2639,385,1119,3191,3343,819,555,3031,784,2149,2748,1075,3152,524,386,1259,218,215,900,3131,1673,525,35,2445,519,158,74,2136,2067,326 0.41529180787632924,-0.2123673195994045,1.4661818634308703,0.3841256925736641,3.200802504118346,-0.8699343008139493,0.5532361269354006,0.04479749007284595,1.07084676596474,0.33701658189477507,0.6431811538013191,0.04479749007284595,0.8471486580863727,-0.9510285615071858,-0.24767692023999524,0.7169539114401163,3.0698107589013315,2.4178172840822203,0.7169539114401163,0.6431811538013191,1.8695432160167267,1.3636206339195902,0.4616874064468927,1.2590315225380515,1.1925938145223307,1.4279535786684734,-0.6344483133432426,1.1388325289942267,0.24146991514915547,-1.2028041638743916,-1.7500104946959263,0.47705956297724367,0.7896879996375533,-0.971515740451046,0.522901157152449,-0.30111518243997987,-0.7116898323792509,0.2735187641595761,-1.1386163266404463,0.861414936766202,1.1388325289942267,0.1604504658814682,1.6287336796515217,1.641034754600386,0.41529180787632924,-1.096295452188383,-0.07357327446040215,0.861414936766202,3.0318170762153325,-0.4649705794159142,0.8756421363992508,1.8813049364421908,2.4178172840822203,-0.2832385860448953,-0.24767692023999524,1.2853737321434007 3430 Abnormality of head blood vessel 11 25 3.360892324381928 0.0007769110660456 P17900,P10619,P07602,P03886,P16278,Q9NZJ7,Q99519,P06865,Q9Y4P3,Q13510,P21964 Drugs and Diseases Human Phenotype Ontology msigdb_hp 66,226,38,73,43,341,340,268,313,250,280 1472,1438,1439,2350,73,268,38,1358,226,2878,43,66,2073,280,2775,360,2670,2879,250,2299,2422,340,341,866,313 0.02805701137235168,0.04479749007284595,0.04479749007284595,-0.40974773902190176,2.4178172840822203,1.4279535786684734,3.0127233121243298,0.09468784334280253,1.6040461907838122,-0.8298890333091614,2.9065277890482055,2.4918352621956807,-0.26542599868242417,1.402314093228658,-0.7311921139115007,1.2059486289837344,-0.6536448751928122,-0.8298890333091614,1.5041368739934033,-0.373271876429598,-0.4464943548499513,1.2590315225380515,1.2590315225380515,0.44626893355334946,1.3246420617522143 3430 Abnormality of the optic nerve 74 262 3.359834247529889 0.0007798924770188 Q7LGA3,P61978,P38435,O95630,P78318,P51798,Q7KZN9,Q9H061,Q92974,Q96CU9,O15460,P06280,O43676,P50897,Q15907,O95202,P98175,P21964,P00403,P04062,Q9P0J0,P49902,Q9H9P8,O95831,Q96KP1,Q10713,Q12768,P07602,P37268,Q86Y39,O75306,P16278,Q13277,P49770,O43681,Q9NZ08,Q9NVI7,Q9Y287,Q15043,Q15067,P04350,O43292,Q9Y6M9,P55011,Q9NPL8,P42858,O75648,P03886,P61586,Q9NZJ7,Q99519,Q96L58,Q96PU5,O96028,Q6P4Q7,Q9UG56,Q9Y2Z2,Q00839,O76024,O96000,O60762,O14936,Q6ZXV5,Q9UBM7,Q8TCJ2,P01889,Q8NAT1,Q5XKP0,P04439,Q9UHX1,Q96PZ0,P51812,Q9H490,O60313 Drugs and Diseases Human Phenotype Ontology msigdb_hp 128,387,136,522,649,524,525,12,526,274,398,275,21,22,276,401,281,280,28,30,158,160,688,414,686,292,550,38,166,168,413,43,427,557,553,185,443,190,191,319,445,194,326,574,325,447,444,73,337,341,340,339,211,334,598,487,488,609,477,606,605,604,233,632,628,369,115,626,244,118,498,619,640,375 906,1472,892,3401,1948,1559,1950,977,2816,1438,604,869,398,1328,194,1439,752,21,2922,553,1142,961,375,2832,605,1473,1776,3300,1441,413,2410,978,1056,1532,1442,1638,444,2818,3149,477,1533,2947,1777,2179,401,2033,1810,1565,522,414,606,2595,334,28,369,73,30,445,244,1877,275,1254,38,2286,1953,3189,2035,1189,2878,983,43,896,1956,1880,2639,1415,3191,280,1665,1997,1850,1851,3031,3011,795,1747,1812,1190,1074,3068,2413,1572,166,136,2748,739,447,1541,2507,1075,796,1543,2967,557,3152,160,2991,2079,22,694,524,619,1120,2670,574,1290,3129,1544,3360,2292,337,387,3034,2992,649,1333,281,1783,609,1199,2934,808,3295,292,2045,550,3296,1921,2558,427,2626,1646,2750,1322,1488,191,319,1126,1374,2996,276,1673,968,680,2092,2841,626,2051,744,2726,598,1104,1235,233,2442,525,1171,128,1897,2563,1795,2846,3017,3073,168,1128,1681,1493,1494,2010,1206,1426,2276,115,2680,998,935,628,1497,2057,2240,1131,1524,2422,526,1176,1624,274,1044,1209,2202,2732,3055,686,339,211,498,937,792,2312,1303,885,340,1837,3001,2124,2016,1463,2518,1212,904,3172,3231,12,1136,1730,2685,640,688,850,1944,325,2208,1764,2022,443,1984,2101,185,341,749,158,1092,632,487,3397,118,2543,2875,855,761,1216,190,2572,488,3213,2213,1808,3043,1025,1698,326 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3430 Corneal opacity 21 59 3.3588618321330337 0.0007826418764589 Q06136,P06280,O95202,P08236,P04062,O75844,O43683,P53701,P16278,Q9Y4P3,Q9NVI7,Q6NUK1,Q99519,O75845,O96028,O75569,Q16625,P10619,P51648,Q8NAT1,Q13510 Drugs and Diseases Human Phenotype Ontology msigdb_hp 258,275,401,279,30,32,539,167,43,313,443,580,340,470,334,342,346,226,110,115,250 977,1438,869,1738,752,539,2987,2350,1097,2574,1056,342,32,470,2179,401,334,1534,30,895,275,279,2431,226,43,896,1415,928,2775,739,1543,2079,110,1120,167,821,2879,1450,2703,258,2046,2626,250,2299,2366,2996,346,580,1796,115,2729,340,850,443,1596,632,866,2875,313 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3430 Intrinsic component of mitochondrial inner membrane 18 30 3.353365767925465 0.0007983512749325 Q9UG56,Q9H9P8,Q9BUR5,Q00325,Q13505,Q16891,Q6P4A7,O14925,Q99595,Q9Y2R0,O60830,Q9Y512,Q16134,Q15070,Q5XKP0,Q96NB2,Q6UXV4,Q9NVH1 Localization GO Cellular component msigdb_gocc 487,688,613,214,58,479,232,204,78,19,20,278,533,181,626,410,697,616 204,1142,20,1010,1029,839,3050,1163,214,58,181,533,479,951,626,232,697,1130,410,78,613,3002,942,688,616,732,487,19,1025,278 1.6777690135569574,0.22536929144369766,3.2100435371001237,0.32121625895525563,0.30536674022651894,0.4616874064468927,-0.992089953515064,0.20921739577808898,1.641034754600386,2.5544966637542177,1.7864835322979642,0.8328430643605732,0.9321647887240839,0.36847097049977656,0.7022834886797121,1.5792439505261,0.6282990804246098,0.24146991514915547,1.0845146796370766,2.3750691920218543,0.7169539114401163,-0.9306276139125141,0.3841256925736641,0.6431811538013191,0.7169539114401163,0.5984052493734849,0.9321647887240839,3.2192694624153164,0.32121625895525563,1.4151493408700357 3430 Ceramide metabolic process 11 18 3.3513216656500195 0.0008042682196405 P17900,O15269,O15270,P06865,O60512,P06280,O95470,Q13510,Q8NCC3,Q96G23,P04062 Processes and pathways GO Biological process msigdb_gobp 66,286,295,268,18,275,86,250,91,124,30 286,295,18,86,30,275,268,1358,66,501,795,2511,250,951,91,124,340,591 1.3894476706931538,1.3636206339195902,3.237676205824806,2.321161071650228,3.0603364192521147,1.4151493408700357,1.4279535786684734,0.09468784334280253,2.4918352621956807,0.8898304908049921,0.5076661391022604,-0.5208177336190014,1.5041368739934033,0.36847097049977656,2.277649032464161,2.066089721766653,1.2590315225380515,0.7461703883999292 3430 Lytic vacuole organization 10 24 3.347982423798781 0.0008140217377814 P42345,O14773,O75503,P50897,P04062,P10253,Q8N511,P54802,Q14108,Q14457 Processes and pathways GO Biological process msigdb_gobp 353,162,104,22,30,311,25,87,60,287 2026,162,104,2285,30,1358,311,370,353,22,1364,87,2186,550,60,287,812,25,1624,2759,3158,1504,1050,2475 -0.24767692023999524,1.8577557582221775,2.189571052524327,-0.373271876429598,3.0603364192521147,0.09468784334280253,1.3246420617522143,1.179204988513675,1.2192696206606266,3.191546309151074,0.09468784334280253,2.321161071650228,-0.31905629408571334,0.8041129767098191,2.5336885717746562,1.3894476706931538,0.4923857069491886,3.1263237819839285,-0.03946755021715677,-0.7116898323792509,-1.1386163266404463,0.02805701137235168,0.30536674022651894,-0.4835161673691688 3430 Abnormal cellular phenotype 45 199 3.305127708866551 0.0009493313218973 P51970,P11177,P51798,Q9UBX3,Q7KZN9,Q96CU9,Q70HW3,Q13315,Q9Y2R0,O43676,Q16134,P21964,P00403,Q9P0J0,P04062,O75844,P23786,O14773,O75306,P07602,Q86Y39,Q9UJW0,P09601,Q14108,Q9Y6M9,Q9NPL8,O75648,P03886,Q06787,O15360,P15586,Q9NZJ7,P13073,Q00325,P12235,O43772,Q14739,P42345,Q6PGP7,Q15904,O75503,P35637,Q4J6C6,Q9Y584,Q13510 Drugs and Diseases Human Phenotype Ontology msigdb_hp 386,509,524,13,525,274,16,400,19,21,533,280,28,158,30,32,33,162,413,38,168,180,59,60,326,325,444,73,203,454,206,341,336,214,213,468,222,353,480,490,104,235,371,119,250 1472,2026,892,1948,1559,1389,1950,977,162,3148,454,21,2922,468,837,1097,2409,1441,413,978,1442,104,444,32,1029,2033,2743,1414,606,28,3027,1534,1314,73,30,1877,38,2035,59,1568,2924,676,3009,509,3358,3046,213,3340,2549,336,3028,1223,206,1743,1444,1146,896,1956,2639,1415,1119,2353,3127,693,280,1997,33,2459,1851,2772,2287,3031,3049,2227,3011,1747,2263,3167,235,2926,3168,2078,2111,948,353,1395,2507,775,2699,796,1258,3152,2361,2079,1363,2509,524,386,2669,2483,2670,2326,2623,2387,2044,695,214,1450,1817,3194,2511,203,1968,3296,1857,2418,400,3071,250,1228,1646,60,222,2995,3220,2439,2366,490,533,1673,625,968,1893,371,651,2092,2786,2907,480,16,525,2302,2846,168,996,1493,1206,935,2565,3261,1083,1683,2422,1176,1378,1459,1624,2873,274,1156,1044,2308,685,1864,1865,937,885,1837,1325,2518,1242,1408,536,816,1089,3371,325,1803,1502,2022,341,749,158,3124,13,708,180,2712,1247,1696,19,2616,3213,2405,1025,119,2815,2281,326 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3430 Glycosylation 20 47 3.280817194025655 0.0010350680664057 O60512,O60502,Q9H0U3,P04062,Q2TAA5,Q16706,Q8N4A0,P46977,Q86YN1,Q10472,Q96L58,O60476,O60762,Q6ZXV5,O75503,Q9BT22,P04844,O15118,Q8NAT1,O60568 Processes and pathways GO Biological process msigdb_gobp 18,147,536,30,288,551,172,430,453,456,339,227,605,233,104,494,362,109,115,376 2107,109,2767,752,837,227,147,18,376,605,1356,104,2743,30,872,362,2228,430,2836,2484,1296,2608,914,875,456,1646,1484,551,288,233,1723,453,172,115,628,339,1657,494,536,1138,3424,850,2963,1556,2687,1349,1698 -0.2832385860448953,2.1784605959005607,-0.7311921139115007,0.5683366593475094,0.4616874064468927,1.5916594876052144,1.904751655596212,3.237676205824806,1.1657819605638418,0.7169539114401163,0.09468784334280253,2.189571052524327,-0.7116898323792509,3.0603364192521147,0.43080383738421585,1.1925938145223307,-0.33706243340680064,1.0296274822176772,-0.7901703605422196,-0.5021316919187672,0.14408985151272588,-0.596278947334594,0.3997325317718629,0.43080383738421585,0.9741576934609325,-0.0564914375226667,0.02805701137235168,0.8041129767098191,1.3894476706931538,1.5792439505261,-0.0907134950668146,0.98808050071691,1.8341031346457968,2.156171440265243,0.7022834886797121,1.2590315225380515,-0.0564914375226667,0.9180915884762,0.8328430643605732,0.24146991514915547,-4.1411192303358,0.4616874064468927,-0.8900812583352817,-0.005591913085313469,-0.6536448751928122,0.11120892157867891,-0.07357327446040215 3430 Amide binding 31 110 3.2737686861379904 0.0010612344503051 P24390,Q9UIQ6,P21796,P10321,P45880,O00264,Q15392,O14773,P07602,Q8WTV0,Q9UM22,Q9Y680,Q9NZ08,Q9Y287,P42892,O60684,P00374,Q9NZJ7,Q92973,Q03519,Q03518,Q9BYT8,O43731,Q9NQX7,Q96AY3,P55899,P01889,P04439,P52294,Q9Y584,P35610 Functions GO Molecular function msigdb_gomf 6,137,9,393,15,143,23,162,38,169,51,56,185,190,69,198,76,341,208,215,218,349,97,225,357,111,369,244,117,119,252 2986,1848,143,1248,1908,1116,3427,2796,162,2348,1635,926,2921,97,198,2381,1098,76,369,244,1811,3421,38,1285,3126,3233,393,3415,2148,2353,9,2261,3328,6,1611,3064,2640,2598,1317,965,252,657,2642,739,948,69,2952,15,3282,796,1258,1915,862,2079,3400,966,117,1033,575,111,2862,1014,2702,2804,2904,1645,1577,218,215,3194,1578,2839,1922,2722,2704,1372,3183,900,23,407,970,169,2338,208,357,1460,1270,3404,2166,517,1085,2912,349,849,1659,474,816,225,1277,185,341,1053,2571,137,51,3079,190,3043,119,56 -0.9306276139125141,-0.15986707294579158,1.9513415899455118,0.1604504658814682,-0.1948058268211105,0.24146991514915547,-4.650483787176411,-0.7507725016906376,1.8577557582221775,-0.40974773902190176,-0.0564914375226667,0.3841256925736641,-0.8699343008139493,2.233787760016152,1.7263589960332117,-0.4280869276823581,0.25751962221115077,2.3964848636249685,1.179204988513675,1.5292904957224467,-0.1424888753229872,-3.7873509360750597,3.0127233121243298,0.14408985151272588,-1.096295452188383,-1.3117306703903504,1.125305736257329,-3.285316956235847,-0.30111518243997987,-0.40974773902190176,3.489279818123242,-0.35513411913799386,-1.6543045466896755,3.713359366894026,-0.03946755021715677,-1.0127520150653435,-0.6344483133432426,-0.596278947334594,0.1276761298241045,0.3527680424371989,1.4915153034770001,0.65802036299361,-0.6344483133432426,0.5833929390939195,0.36847097049977656,2.4496613605694386,-0.8900812583352817,3.2925394092933984,-1.468526945815869,0.5076661391022604,0.1604504658814682,-0.1948058268211105,0.44626893355334946,-0.26542599868242417,-2.3420518460725406,0.3527680424371989,2.1113172784145564,0.30536674022651894,0.7607169539788241,2.1784605959005607,-0.8099892376198776,0.32121625895525563,-0.6729168790091554,-0.7507725016906376,-0.8498704751461239,-0.0564914375226667,-0.02250118346835699,1.6287336796515217,1.641034754600386,-1.2028041638743916,-0.02250118346835699,-0.7901703605422196,-0.1948058268211105,-0.6922649775615227,-0.6729168790091554,0.09468784334280253,-1.1813127889529935,0.41529180787632924,3.1543688124281597,1.0845146796370766,0.3527680424371989,1.8459424393187207,-0.3914762369552328,1.6777690135569574,1.2192696206606266,0.04479749007284595,0.1604504658814682,-2.4814738005103227,-0.30111518243997987,0.8756421363992508,0.2735187641595761,-0.8498704751461239,1.2458108826688405,0.4616874064468927,-0.0564914375226667,0.9462000577616902,0.4923857069491886,1.6164042064007391,0.1604504658814682,1.774512395985724,1.2590315225380515,0.30536674022651894,-0.558403728184664,1.9975331678372859,2.677725710562994,-1.0127520150653435,1.7625145060761207,-0.971515740451046,2.1113172784145564,2.606176282501621 3430 Glycosaminoglycan metabolism 9 15 3.273231599060609 0.0010632531778991 Q7LGA3,P16278,P15586,Q9UL01,P06865,O60512,P54802,Q8TB61,P08236 Processes and pathways Reactome Pathways msigdb_reactome 128,43,206,79,268,18,87,55,279 1664,752,18,1637,268,1358,279,206,43,87,128,55,339,2687,79 -0.07357327446040215,0.5683366593475094,3.237676205824806,-0.0564914375226667,1.4279535786684734,0.09468784334280253,1.402314093228658,1.6777690135569574,2.9065277890482055,2.321161071650228,2.0547236877093185,2.606176282501621,1.2590315225380515,-0.6536448751928122,2.3750691920218543 3430 Glycoside hydrolase superfamily [IPR017853] 8 16 3.269760452900946 0.0010763859463875 Q9BTY2,P16278,P06865,P06280,O60502,P54802,P08236,P04062 Sequence InterPro Superfamily interpro_homologous_superfamily 202,43,268,275,147,87,279,30 147,30,895,275,268,1358,1567,279,311,43,1224,87,741,1202,202,1066 1.904751655596212,3.0603364192521147,0.41529180787632924,1.4151493408700357,1.4279535786684734,0.09468784334280253,-0.02250118346835699,1.402314093228658,1.3246420617522143,2.9065277890482055,0.17675834803240076,2.321161071650228,0.5833929390939195,0.19301386899346543,1.7142527679704935,0.2894676887918951 3430 Carbohydrate derivative catabolic process 16 38 3.267554243682912 0.0010848107588543 P49902,P17900,Q9BTY2,P16278,P15586,Q99519,P06865,Q9H773,P06280,Q13126,O60502,P35610,P54802,P08236,Q9NUJ1,P04062 Processes and pathways GO Biological process msigdb_gobp 160,66,202,43,206,340,268,305,275,113,147,252,87,279,221,30 350,2986,147,3027,2618,30,895,275,268,1358,279,2549,206,43,66,2354,3382,252,2506,3104,2040,160,87,2511,113,1863,628,516,2423,340,202,2492,3377,305,221,2765,3024,2025 1.2325569767034361,-0.9306276139125141,1.904751655596212,-0.971515740451046,-0.6153265492951593,3.0603364192521147,0.41529180787632924,1.4151493408700357,1.4279535786684734,0.09468784334280253,1.402314093228658,-0.558403728184664,1.6777690135569574,2.9065277890482055,2.4918352621956807,-0.40974773902190176,-2.0753063910430853,1.4915153034770001,-0.5208177336190014,-1.0543430004362901,-0.24767692023999524,1.8695432160167267,2.321161071650228,-0.5208177336190014,2.167327425815136,-0.15986707294579158,0.7022834886797121,0.8756421363992508,-0.4464943548499513,1.2590315225380515,1.7142527679704935,-0.5021316919187672,-1.9981963448778324,1.3506596827179598,1.6287336796515217,-0.7116898323792509,-0.9510285615071858,-0.22999085661134913 3430 Sensorimotor neuropathy 9 30 3.250198254628381 0.0011532458075864 Q15120,P07602,P03886,O15270,Q9NZJ7,Q9Y2R0,Q9NR77,O60313,P00403 Drugs and Diseases Human Phenotype Ontology msigdb_hp 389,38,73,295,341,19,123,375,28 1559,295,375,414,28,73,607,1254,38,1569,3062,1074,948,2361,1194,2387,2510,2045,1335,389,1494,1524,3055,2243,123,1903,2102,341,19,1025 -0.02250118346835699,1.3636206339195902,1.1657819605638418,1.07084676596474,3.0698107589013315,2.4178172840822203,0.7169539114401163,0.1604504658814682,3.0127233121243298,-0.02250118346835699,-1.0127520150653435,0.2735187641595761,0.36847097049977656,-0.40974773902190176,0.19301386899346543,-0.4280869276823581,-0.5208177336190014,-0.24767692023999524,0.11120892157867891,1.1388325289942267,0.02805701137235168,0.01126068031324202,-0.992089953515064,-0.33706243340680064,2.077431989617715,-0.1773059016141884,-0.26542599868242417,1.2590315225380515,3.2192694624153164,0.32121625895525563 3430 Abnormal muscle fiber morphology 19 70 3.21153483507353 0.0013202796268212 P61978,Q70HW3,O43676,Q99720,P00403,O95831,P23786,P50402,Q9H2D1,P31483,P03886,P05067,P51114,P22626,P12235,Q96RL7,P35637,O14979,O60313 Drugs and Diseases Human Phenotype Ontology msigdb_hp 387,16,21,26,28,414,33,431,49,322,73,205,84,343,213,358,235,108,375 1950,108,21,2217,375,1875,1356,444,414,1443,28,1534,73,3319,205,2819,1254,2548,981,1255,213,1475,2859,343,33,1747,322,3167,235,3234,585,775,431,1192,84,1100,2483,2387,387,1296,2608,1670,2298,3275,651,1676,16,1897,2302,2274,920,2565,1043,358,937,26,1325,1087,1212,49,3424,850,1089,2132,2712,1350,3241,1025,2815,1698 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3430 Abnormality of the mitochondrion 24 93 3.206687165592355 0.0013427292626997 P51970,P11177,Q96CU9,Q9UBX3,Q7KZN9,Q70HW3,Q9Y2R0,O43676,P00403,Q9P0J0,O75306,P23786,Q86Y39,Q9Y6M9,Q9NPL8,O75648,P03886,P13073,Q00325,P12235,O43772,P35637,Q4J6C6,Q9Y584 Drugs and Diseases Human Phenotype Ontology msigdb_hp 386,509,274,13,525,16,19,21,28,158,413,33,168,326,325,444,73,336,214,213,468,235,371,119 892,1948,1559,1950,21,2922,468,1441,413,978,1442,444,1029,2033,606,28,73,2035,1568,2924,509,3358,213,336,3028,2639,1119,693,1997,33,1851,3031,3011,1747,235,2926,3168,948,1395,2507,775,1258,3152,2079,386,2669,2483,2623,2387,695,214,1968,2418,2995,533,1673,625,968,1893,371,651,2092,2786,16,525,2302,2846,168,1493,935,2565,1459,274,1044,1865,937,1837,1325,2518,1408,816,1089,325,749,158,3124,13,2712,19,2616,1025,119,326 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3430 Functional abnormality of the gastrointestinal tract 61 288 3.20525352472662 0.001349435641025 O75874,P61978,O14678,P61916,P48735,O15460,Q13045,P51571,P06280,O95202,Q01844,Q99720,P21964,Q9UGP8,P04062,P00403,O75306,P08183,O15269,Q12768,P07602,O15270,Q9Y619,Q9Y4P3,Q9NZ08,Q14108,Q96D71,Q15067,Q6NUK1,P04350,P42858,P55011,P55795,P42892,P03886,Q06787,P05067,P15586,Q9NZJ7,Q99519,Q96PU5,O96028,O75569,P12235,Q8IZA0,Q14739,O76024,Q96RL7,P16435,Q6PGP7,Q6ZXV5,P35637,Q5HYI8,O15118,P01889,Q9UHX1,Q9Y584,Q96A33,Q13510,Q9NR77,O60313 Drugs and Diseases Human Phenotype Ontology msigdb_hp 1,387,257,512,10,398,531,403,275,401,282,26,280,547,30,28,413,159,286,550,38,295,45,313,185,60,582,319,580,445,447,574,196,69,73,203,205,206,341,340,211,334,342,213,93,222,477,358,231,480,233,235,491,109,369,118,119,379,250,123,375 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3430 Protein insertion into membrane 14 29 3.201973758971659 0.0013648943092883 P46379,Q9Y5J9,O14737,Q9NS69,Q96A33,O43681,Q9Y512,Q15070,Q15629,Q9Y5J7,Q9Y584,Q9P0J0,Q9Y5L4,P07900 Processes and pathways GO Biological process msigdb_gobp 256,193,165,7,379,553,278,181,116,571,119,158,125,656 165,553,1809,1098,656,2505,3218,256,1014,988,1618,181,116,951,790,1586,1426,1236,379,703,7,2446,158,1350,278,119,571,193,125 1.8459424393187207,0.7896879996375533,-0.1424888753229872,0.25751962221115077,0.65802036299361,-0.5208177336190014,-1.267862233870033,1.47886368568901,0.32121625895525563,0.33701658189477507,-0.03946755021715677,1.7864835322979642,2.133790611209967,0.36847097049977656,0.522901157152449,-0.02250118346835699,0.06148252180205109,0.17675834803240076,1.1657819605638418,0.6282990804246098,3.602417135580486,-0.4649705794159142,1.8813049364421908,0.11120892157867891,1.4151493408700357,2.1113172784145564,0.7752227411673067,1.750489731196436,2.066089721766653 3430 Abnormal retinal artery morphology 10 22 3.1994080271021645 0.001377101182032 P17900,P10619,P07602,P03886,P16278,Q9NZJ7,P06865,Q9Y4P3,Q13510,P21964 Drugs and Diseases Human Phenotype Ontology msigdb_hp 66,226,38,73,43,341,268,313,250,280 1472,1439,2350,73,268,38,1358,226,2878,43,66,280,2775,2670,2879,250,2299,2422,340,341,866,313 0.02805701137235168,0.04479749007284595,-0.40974773902190176,2.4178172840822203,1.4279535786684734,3.0127233121243298,0.09468784334280253,1.6040461907838122,-0.8298890333091614,2.9065277890482055,2.4918352621956807,1.402314093228658,-0.7311921139115007,-0.6536448751928122,-0.8298890333091614,1.5041368739934033,-0.373271876429598,-0.4464943548499513,1.2590315225380515,1.2590315225380515,0.44626893355334946,1.3246420617522143 3430 Electron transport 20 46 3.1928549007760902 0.0014087371432027 P51970,Q96CU9,O43169,O95168,O43676,Q16134,O14949,P00403,Q9P0J0,O75306,Q86Y39,P08574,O75438,Q9H1E5,O95864,Q9Y6M9,P03886,Q9UDW1,Q6DKK2,O96000 Processes and pathways Protein Atlas Biological process protein_atlas_biological_process 386,274,14,529,21,533,155,28,158,413,168,296,671,171,554,326,73,74,82,606 892,1950,155,14,1311,21,2922,1441,413,978,671,1442,529,3008,2033,554,606,28,73,296,3028,3331,2639,693,1997,984,3031,1747,784,3168,1075,3152,386,533,3131,1673,2784,82,168,274,1499,171,831,158,74,326 0.41529180787632924,-0.2123673195994045,1.8813049364421908,3.3468758304359083,0.1276761298241045,3.200802504118346,-0.8699343008139493,0.04479749007284595,1.07084676596474,0.33701658189477507,0.6431811538013191,0.04479749007284595,0.8471486580863727,-0.9510285615071858,-0.24767692023999524,0.7896879996375533,0.7169539114401163,3.0698107589013315,2.4178172840822203,1.3636206339195902,-0.971515740451046,-1.6780491319681583,-0.6344483133432426,0.6282990804246098,-0.22999085661134913,0.33701658189477507,-0.971515740451046,-0.10791253841717666,0.522901157152449,-1.1599171531024435,0.2735187641595761,-1.1386163266404463,1.1388325289942267,0.8328430643605732,-1.096295452188383,-0.07357327446040215,-0.7311921139115007,2.342788021416518,1.8459424393187207,1.4279535786684734,0.02805701137235168,1.8459424393187207,0.47705956297724367,1.8813049364421908,2.4178172840822203,1.2853737321434007 3430 Abnormal circulating lipid concentration 22 80 3.189365373969269 0.0014258553525789 P61916,P06280,Q15392,Q8N511,O75844,P23786,P07602,P37268,P50402,P22830,Q9Y4P3,Q9NVI7,P42858,O75648,Q9NZJ7,O75845,O95470,Q15800,O43772,Q14739,Q15904,Q96MF7 Drugs and Diseases Human Phenotype Ontology msigdb_hp 512,275,23,25,32,33,38,166,431,438,313,443,447,444,341,470,86,88,468,222,490,507 1438,781,2350,468,1056,1010,444,32,470,1029,86,1534,275,1566,38,1568,3358,438,33,2287,897,928,2775,1224,2926,166,2183,739,948,447,2778,677,1258,431,1058,2079,3310,1194,2462,2510,1195,512,2879,1450,1227,1968,875,531,3071,1670,222,2299,23,1169,88,490,625,1893,1620,3313,25,2395,1043,1524,1378,507,2759,1087,816,443,341,632,866,708,1599,1808,313,3043,2815,3176 0.04479749007284595,0.522901157152449,-0.40974773902190176,0.9462000577616902,0.2894676887918951,0.32121625895525563,1.001966258000303,3.050846065270086,0.9462000577616902,0.30536674022651894,2.321161071650228,-0.005591913085313469,1.4151493408700357,-0.02250118346835699,3.0127233121243298,-0.02250118346835699,-1.8477085071425041,1.0158151806848401,3.0318170762153325,-0.373271876429598,0.41529180787632924,0.3841256925736641,-0.7311921139115007,0.17675834803240076,-0.8699343008139493,1.8459424393187207,-0.31905629408571334,0.5833929390939195,0.36847097049977656,1.001966258000303,-0.7311921139115007,0.6431811538013191,0.1604504658814682,1.0296274822176772,0.2894676887918951,-0.26542599868242417,-1.5605037593216007,0.19301386899346543,-0.4835161673691688,-0.5208177336190014,0.19301386899346543,0.8756421363992508,-0.8298890333091614,0.04479749007284595,0.17675834803240076,-0.2123673195994045,0.43080383738421585,0.8471486580863727,-1.0127520150653435,-0.07357327446040215,1.6164042064007391,-0.373271876429598,3.1543688124281597,0.20921739577808898,2.310315469590055,0.9180915884762,0.7022834886797121,-0.1773059016141884,-0.03946755021715677,-1.5605037593216007,3.1263237819839285,-0.4280869276823581,0.30536674022651894,0.01126068031324202,0.09468784334280253,0.8898304908049921,-0.7116898323792509,0.2735187641595761,0.4923857069491886,1.0158151806848401,1.2590315225380515,0.7022834886797121,0.44626893355334946,0.6282990804246098,-0.02250118346835699,-0.12517084870498654,1.3246420617522143,-0.971515740451046,-0.7507725016906376,-1.1599171531024435 3430 Talipes equinovarus 24 81 3.179201663104122 0.0014768130649569 P61978,Q8TB36,O95202,Q15907,Q15392,P98175,P21964,P08236,P49902,Q9Y619,Q9Y487,Q9NWM8,Q15427,Q6NUQ1,Q9UL01,Q96L58,O75845,O96028,Q96AY3,P16435,Q6ZXV5,Q96A33,Q9NR77,O60568 Drugs and Diseases Human Phenotype Ontology msigdb_hp 387,390,401,276,23,281,280,279,160,45,175,179,312,452,79,339,470,334,357,231,233,379,123,376 1472,2107,977,2816,3060,2217,376,2574,470,2947,401,334,2225,2819,279,1145,1255,231,1880,3127,280,2800,2149,2748,2620,1710,1961,160,2079,1194,2821,2670,821,387,281,1198,1296,2703,2045,2626,2234,542,23,312,276,1756,452,233,3017,1040,1079,920,482,390,639,2872,3261,2422,379,357,3055,339,1657,2279,1730,1067,123,179,79,2875,855,668,2139,2170,1436,175,2741,2281,891,3388,45 0.02805701137235168,-0.2832385860448953,0.33701658189477507,-0.7704316844994457,-1.0127520150653435,-0.33706243340680064,1.1657819605638418,-0.5773048800496771,0.9462000577616902,-0.8900812583352817,1.0981470112960925,1.2590315225380515,-0.33706243340680064,-0.7704316844994457,1.402314093228658,0.22536929144369766,0.1604504658814682,1.5792439505261,-0.1773059016141884,-1.096295452188383,1.402314093228658,-0.7507725016906376,-0.30111518243997987,-0.7116898323792509,-0.6153265492951593,-0.0907134950668146,-0.2123673195994045,1.8695432160167267,-0.26542599868242417,0.19301386899346543,-0.7704316844994457,-0.6536448751928122,0.47705956297724367,1.1388325289942267,1.402314093228658,0.19301386899346543,0.14408985151272588,-0.6729168790091554,-0.24767692023999524,-0.6153265492951593,-0.33706243340680064,0.8184979173823138,3.1543688124281597,1.3246420617522143,1.4151493408700357,-0.10791253841717666,0.98808050071691,1.5792439505261,-0.9510285615071858,0.30536674022651894,0.2735187641595761,0.3997325317718629,0.9321647887240839,1.1388325289942267,0.6875712647067221,-0.8099892376198776,-1.3782981393570042,-0.4464943548499513,1.1657819605638418,1.2192696206606266,-0.992089953515064,1.2590315225380515,-0.0564914375226667,-0.35513411913799386,-0.0907134950668146,0.2894676887918951,2.077431989617715,1.798428045397234,2.3750691920218543,-0.8099892376198776,0.4616874064468927,0.65802036299361,-0.2832385860448953,-0.30111518243997987,0.06148252180205109,1.8103460646896083,-0.6922649775615227,-0.35513411913799386,0.43080383738421585,-2.1012974711813244,2.7982738550861823 3430 Glycoprotein metabolic process 25 62 3.1780589250993767 0.0014826461515307 Q7LGA3,O14734,O60512,O60502,Q9H0U3,Q2TAA5,Q16706,Q8N4A0,P46977,Q9Y287,Q86YN1,Q10472,Q9UL01,Q96L58,Q9NQX7,Q92542,O60476,O60762,Q6ZXV5,Q9BT22,P04844,O15118,Q8NAT1,P35610,O60568 Processes and pathways GO Biological process msigdb_gobp 128,391,18,147,536,288,551,172,430,190,453,456,79,339,225,612,227,605,233,494,362,109,115,252,376 2107,977,391,109,2767,752,837,227,147,18,376,2546,605,2220,1356,2743,872,362,1536,1190,252,2228,430,2836,2004,2484,1296,2608,914,875,456,1646,1484,1202,551,288,233,128,1723,453,172,115,628,612,2849,339,3387,1628,494,536,2206,1138,748,3424,850,225,1246,1556,2687,79,190,1698 -0.2832385860448953,0.33701658189477507,1.125305736257329,2.1784605959005607,-0.7311921139115007,0.5683366593475094,0.4616874064468927,1.5916594876052144,1.904751655596212,3.237676205824806,1.1657819605638418,-0.558403728184664,0.7169539114401163,-0.33706243340680064,0.09468784334280253,-0.7116898323792509,0.43080383738421585,1.1925938145223307,-0.005591913085313469,0.19301386899346543,1.4915153034770001,-0.33706243340680064,1.0296274822176772,-0.7901703605422196,-0.22999085661134913,-0.5021316919187672,0.14408985151272588,-0.596278947334594,0.3997325317718629,0.43080383738421585,0.9741576934609325,-0.0564914375226667,0.02805701137235168,0.19301386899346543,0.8041129767098191,1.3894476706931538,1.5792439505261,2.0547236877093185,-0.0907134950668146,0.98808050071691,1.8341031346457968,2.156171440265243,0.7022834886797121,0.7169539114401163,-0.7901703605422196,1.2590315225380515,-2.1012974711813244,-0.03946755021715677,0.9180915884762,0.8328430643605732,-0.31905629408571334,0.24146991514915547,0.5833929390939195,-4.1411192303358,0.4616874064468927,1.6164042064007391,0.17675834803240076,-0.005591913085313469,-0.6536448751928122,2.3750691920218543,1.7625145060761207,-0.07357327446040215 3430 Secondary active transmembrane transporter activity 13 19 3.1687697545754654 0.0015308561537104 P12236,Q02978,Q96ES6,P55011,P51798,Q9UBX3,P53985,Q9BXP2,O95202,Q00325,P12235,Q9Y6M7,Q15043 Functions GO Molecular function msigdb_gomf 418,696,37,574,524,13,271,601,401,214,213,548,191 401,736,1567,213,418,524,1100,271,574,214,696,191,950,1130,37,601,1409,13,548 1.0981470112960925,0.5833929390939195,-0.02250118346835699,1.641034754600386,1.057143066123191,0.861414936766202,0.25751962221115077,1.4279535786684734,0.7607169539788241,1.641034754600386,0.6282990804246098,1.750489731196436,0.36847097049977656,0.24146991514915547,3.0222783212407616,0.7315827923762055,0.07811250742307049,3.391761695054266,0.8184979173823138 3430 Hormone metabolic process 9 29 3.1649308871857604 0.0015511979228564 O75844,P30536,P42892,P16435,Q9HB40,Q06520,Q6NUM9,O95470,Q14849 Processes and pathways GO Biological process msigdb_gobp 32,2,69,231,40,144,216,86,27 2256,32,3338,86,607,2148,3141,231,2,740,69,3169,1194,2081,2556,144,27,2190,262,216,1207,1623,1175,1499,1837,40,632,3097,768 -0.35513411913799386,3.050846065270086,-1.725900749051077,2.321161071650228,0.7169539114401163,-0.30111518243997987,-1.117409393747407,1.5792439505261,3.92901774642917,0.5833929390939195,2.4496613605694386,-1.1599171531024435,0.19301386899346543,-0.26542599868242417,-0.558403728184664,1.9513415899455118,3.0792691433168833,-0.31905629408571334,1.4534696782308594,1.641034754600386,0.19301386899346543,-0.03946755021715677,0.20921739577808898,0.02805701137235168,-0.1424888753229872,2.983960149974089,0.7022834886797121,-1.0335027512907717,0.5532361269354006 3430 Limitation of joint mobility 27 103 3.153003902796006 0.0016159964629494 Q7LGA3,O75874,P48735,O15460,Q13045,P08236,O75844,P23786,P37268,P16278,P50402,Q15427,Q9Y4P3,P15586,Q96L58,Q13535,P54802,Q8TAA9,Q96AY3,O76024,P16435,P48651,P51648,O14979,Q9BT22,P01889,O60568 Drugs and Diseases Human Phenotype Ontology msigdb_hp 128,1,10,398,531,279,32,33,166,43,431,312,313,206,339,338,87,482,357,477,231,360,110,108,494,369,376 1389,2107,977,2816,1026,108,3322,398,3060,2350,837,2283,376,2594,2284,2574,1010,2145,32,1,477,2070,1777,927,369,1534,2819,279,1954,1255,206,43,231,896,3127,2859,33,2800,1813,1190,2775,166,3234,360,10,431,2509,110,87,821,2387,2879,1450,1296,2703,741,1165,2556,2045,3296,531,338,1670,3275,2113,2091,542,1488,2299,312,2051,128,1206,1040,482,2565,639,2872,1523,1043,3346,2120,1834,1624,357,2308,685,339,2312,2124,494,1087,2279,1730,1944,2521,866,2066,2712,2170,1470,313,1847 0.07811250742307049,-0.2832385860448953,0.33701658189477507,-0.7704316844994457,0.30536674022651894,2.1784605959005607,-1.6306790060749776,1.1117439633053623,-1.0127520150653435,-0.40974773902190176,0.4616874064468927,-0.373271876429598,1.1657819605638418,-0.596278947334594,-0.373271876429598,-0.5773048800496771,0.32121625895525563,-0.30111518243997987,3.050846065270086,3.92901774642917,0.9321647887240839,-0.26542599868242417,-0.12517084870498654,0.3841256925736641,1.179204988513675,-0.005591913085313469,-0.7704316844994457,1.402314093228658,-0.2123673195994045,0.1604504658814682,1.6777690135569574,2.9065277890482055,1.5792439505261,0.41529180787632924,-1.096295452188383,-0.8099892376198776,3.0318170762153325,-0.7507725016906376,-0.1424888753229872,0.19301386899346543,-0.7311921139115007,1.8459424393187207,-1.3117306703903504,1.2059486289837344,3.454011813127605,1.0296274822176772,-0.5208177336190014,2.1784605959005607,2.321161071650228,0.47705956297724367,-0.4280869276823581,-0.8298890333091614,0.04479749007284595,0.14408985151272588,-0.6729168790091554,0.5833929390939195,0.20921739577808898,-0.558403728184664,-0.24767692023999524,-1.5142922206614813,0.8471486580863727,1.2590315225380515,-0.07357327446040215,-1.445808727840182,-0.2832385860448953,-0.26542599868242417,0.8184979173823138,0.02805701137235168,-0.373271876429598,1.3246420617522143,-0.24767692023999524,2.0547236877093185,0.19301386899346543,0.30536674022651894,0.9321647887240839,-0.558403728184664,0.6875712647067221,-0.8099892376198776,0.01126068031324202,0.30536674022651894,-1.7500104946959263,-0.2832385860448953,-0.1424888753229872,-0.03946755021715677,1.2192696206606266,-0.373271876429598,0.6431811538013191,1.2590315225380515,-0.373271876429598,-0.2832385860448953,0.9180915884762,0.2735187641595761,-0.35513411913799386,-0.0907134950668146,-0.1948058268211105,-0.5208177336190014,0.44626893355334946,-0.24767692023999524,-0.6729168790091554,-0.30111518243997987,0.04479749007284595,1.3246420617522143,-0.1424888753229872 3430 Arthritis 12 43 3.118584738146869 0.0018172187883684 O75844,Q96RL7,P10321,P01889,P06280,Q96HY6,Q9NZ08,Q13510,P21964,Q14108,Q14739,P04062 Drugs and Diseases Human Phenotype Ontology msigdb_hp 32,358,393,369,275,380,185,250,280,60,222,30 2173,1472,398,3248,32,2618,369,1534,30,275,2548,393,3046,1223,280,2859,2287,796,1363,1612,524,1712,2670,1290,1014,1450,2511,250,60,222,2091,822,2302,996,2422,380,358,1138,185,750,1470,2025,3213 -0.31905629408571334,0.02805701137235168,1.1117439633053623,-1.3560056220962575,3.050846065270086,-0.6153265492951593,1.179204988513675,-0.005591913085313469,3.0603364192521147,1.4151493408700357,-0.558403728184664,1.125305736257329,-0.992089953515064,0.17675834803240076,1.402314093228658,-0.8099892376198776,-0.373271876429598,0.5076661391022604,0.09468784334280253,-0.03946755021715677,0.861414936766202,-0.0907134950668146,-0.6536448751928122,0.14408985151272588,0.32121625895525563,0.04479749007284595,-0.5208177336190014,1.5041368739934033,2.5336885717746562,1.6164042064007391,-0.26542599868242417,0.47705956297724367,-0.373271876429598,0.33701658189477507,-0.4464943548499513,1.1657819605638418,1.2192696206606266,0.24146991514915547,1.774512395985724,0.5833929390939195,0.04479749007284595,-0.22999085661134913,-1.2460779206914567 3430 Abnormality of coordination 61 332 3.117213906889164 0.0018256905106737 Q9NP80,Q96CU9,O15460,Q13315,O43676,P50897,Q15907,O95202,Q99707,Q99720,O14949,P00403,P04062,Q9P0J0,Q2TAA5,O95831,O14773,O75306,Q10713,P07602,Q86Y39,P16278,Q9Y619,Q9Y487,Q9Y4P3,Q9NZ08,P07437,Q9NVI7,Q14108,Q9Y287,Q15067,P04350,O43292,Q9Y6M9,P55795,Q9NPL8,P31483,P03886,Q06787,P00374,P05067,Q9NZJ7,Q99519,Q6DKK2,O96028,Q5JRX3,O95470,P12235,O60313,Q96RL7,Q6P4A7,O75503,P35637,P14854,O15118,P01889,Q8IV08,Q13510,Q9NR77,P35610,Q14738 Drugs and Diseases Human Phenotype Ontology msigdb_hp 264,274,398,400,21,22,276,401,284,26,155,28,30,158,288,414,162,413,292,38,168,43,45,175,313,185,310,443,60,190,319,445,194,326,196,325,322,73,203,76,205,341,340,82,334,85,86,213,375,358,232,104,235,363,109,369,120,250,123,252,254 892,1948,1559,1950,2346,467,977,162,1438,604,155,794,869,109,2407,398,194,21,2922,553,2350,2817,1142,375,1874,2478,605,1776,763,870,1441,413,1356,978,1056,1532,1442,104,1250,477,1413,2179,401,2033,1810,1565,2743,1414,86,2695,3045,2502,414,606,1443,334,76,28,3027,3330,369,73,30,3349,445,205,2352,2819,1254,3082,310,38,1358,2286,2035,1568,2924,1255,676,509,1222,3358,2856,213,2433,363,2878,983,43,1996,896,1569,1880,2639,1415,2324,1446,2073,693,737,1997,2354,1851,2772,1393,738,3031,3049,3011,3165,1747,322,1478,2775,1074,2110,252,235,657,2926,3068,804,1572,2748,2111,739,948,1961,1395,447,1541,1884,2507,2290,2699,3282,796,2967,2039,2927,3152,2361,2079,3400,22,2509,1963,1194,2669,1100,1713,821,2387,2510,1290,196,1195,2292,512,3034,2555,2879,1034,2529,1783,1198,1334,1015,1227,741,3054,1165,3295,2608,203,292,2045,550,3296,2418,1335,400,2626,3071,250,2235,1670,60,2298,3228,1582,2113,254,1398,2995,2299,319,1821,1078,2996,276,2905,1673,288,1893,85,1262,2157,626,2842,82,2786,232,1104,1235,2610,525,993,1171,1897,994,2563,2654,1795,2846,168,120,1128,933,1493,1494,1206,1040,2680,3355,920,935,1175,2788,1497,1237,1083,2729,1683,2338,526,1176,1378,1685,1000,274,1270,582,1209,1001,2732,972,2758,3055,1657,3158,358,937,2761,2312,2243,1303,885,340,284,1837,26,3001,3135,2124,1463,2518,1212,904,1005,2279,3172,2018,3231,3188,3424,1409,850,264,325,3374,2521,2963,123,1764,443,1984,2101,2133,185,2102,341,749,158,1092,3124,1529,975,3397,2687,1068,866,1845,3097,1349,1695,1350,190,2896,1436,3213,175,1808,313,1847,3043,1025,2741,1698,891,45,326 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3430 Nuclear envelope 51 180 3.105215067624758 0.0019014071632574 Q8TD16,P57088,P80303,Q9HB71,Q86UE4,P67809,O00560,Q5SRE5,Q5SNT2,Q99720,Q8IXM6,O75844,Q15154,Q9P035,Q6ZRP7,Q5BJF2,Q7Z3B4,Q99567,Q9H1E5,Q9H2V7,Q9UH99,P50402,P07437,Q8N201,Q96KC8,P62995,Q9BZF1,O15397,P43243,P05067,Q9NXE4,Q8NFQ8,Q9C0E2,Q99523,Q6NUM9,P41208,Q9BTX1,Q8N1F7,Q14739,P42345,O15173,Q12769,Q9NQC3,Q8NFH4,Q9NUQ2,Q9UBM7,O15118,O94901,P52294,O76062,Q14728 Localization GO Cellular component msigdb_gocc 639,511,5,654,263,396,266,662,661,26,156,32,543,294,552,299,559,42,171,46,434,431,310,450,324,576,458,328,585,205,591,83,602,600,216,344,92,611,222,353,99,478,359,627,367,632,109,368,117,382,638 1737,2852,1248,1908,266,1116,2816,893,2215,109,99,328,3335,1992,1775,2946,2145,2694,979,32,382,368,1251,1534,2717,205,3216,310,2768,2036,2431,1509,1535,1706,2857,947,2900,1446,3048,3064,657,2506,1572,344,786,1148,353,1395,1884,585,2777,1447,3103,1543,1915,862,3362,431,912,117,1033,3105,1418,2080,511,1195,2267,2416,576,1815,396,1966,5,1513,2703,1227,988,3353,478,1422,1200,1785,1485,638,222,1372,2189,543,2905,299,1204,1676,1103,661,662,2486,216,552,559,1678,263,2008,1425,2336,156,1154,611,450,1725,2959,1341,2421,627,83,639,1267,1833,2682,1043,1899,2163,747,903,3000,324,2424,2203,2760,792,1758,600,1939,42,26,1085,2887,1087,92,2961,1981,2912,886,2492,1465,458,602,171,46,3342,941,654,1983,359,1764,2494,367,1434,707,591,2248,3271,294,1734,632,1215,434,1385,3022,1906,2894,1348,2402,1990,1024,1470,2616,2985,1697,2815,1007 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3430 protein modifying enzyme 12 26 3.101550620429467 0.0019250995487103 O60725,Q15418,Q86YN1,O60476,O14744,O15460,Q6P2P2,P50897,O75718,P13674,Q92791,O60568 Functions Panther Protein class panther_protein_class 65,354,453,227,461,398,277,22,89,314,219,376 2107,461,2767,398,227,376,2256,65,89,314,22,619,2837,1296,2087,2391,354,2754,277,1205,453,1266,219,2278,1138,476 -0.2832385860448953,0.9601976189085124,-0.7311921139115007,1.1117439633053623,1.5916594876052144,1.1657819605638418,-0.35513411913799386,2.4918352621956807,2.2994483251380298,1.311585046538852,3.191546309151074,0.7022834886797121,-0.7901703605422196,0.14408985151272588,-0.26542599868242417,-0.4280869276823581,1.2192696206606266,-0.7116898323792509,1.4151493408700357,0.19301386899346543,0.98808050071691,0.1604504658814682,1.6287336796515217,-0.35513411913799386,0.24146991514915547,0.9462000577616902 3430 Skin nodule 7 21 3.09427236833938 0.0019729626952045 O75874,P48735,P35637,P16615,P06280,Q9NZ08,Q13510 Drugs and Diseases Human Phenotype Ontology msigdb_hp 1,10,235,269,275,185,250 1874,1,369,858,275,1535,269,693,928,1190,235,10,796,1120,1450,2556,250,2241,1903,185,1470 -0.1773059016141884,3.92901774642917,1.179204988513675,0.44626893355334946,1.4151493408700357,-0.005591913085313469,1.4279535786684734,0.6282990804246098,0.3841256925736641,0.19301386899346543,1.5667994320520733,3.454011813127605,0.5076661391022604,0.24146991514915547,0.04479749007284595,-0.558403728184664,1.5041368739934033,-0.33706243340680064,-0.1773059016141884,1.774512395985724,0.04479749007284595 3430 Vascular skin abnormality 30 125 3.089957937562823 0.0020018484310886 Q06136,P38435,Q13315,P06280,P21964,P00403,P04062,O75844,O75306,P53701,P16278,Q9Y487,Q9NWM8,Q15427,P22830,Q14108,P03886,Q9UL01,Q99519,Q96L58,Q13535,Q16625,Q14739,Q8IZA0,P10619,P48651,P51648,P01889,Q13126,O60568 Drugs and Diseases Human Phenotype Ontology msigdb_hp 258,136,400,275,280,28,30,32,413,167,43,175,179,312,438,60,73,79,340,339,338,346,222,93,226,360,110,369,113,376 2173,1472,1438,454,2283,376,605,1776,2594,413,3248,32,1777,2743,1414,3045,28,369,1534,73,30,895,275,2526,2431,226,1189,2856,3340,1743,43,1444,2109,3303,896,1415,3127,2073,693,280,3163,438,3064,897,2800,3066,1813,1190,1911,2149,3281,136,2748,2111,1710,360,677,796,2361,110,524,619,167,2670,2326,821,1290,2934,1296,2511,2556,258,788,1578,1297,1857,113,400,3071,338,60,2113,222,2389,1821,312,1169,346,2652,680,822,2841,953,2051,580,2193,1019,698,93,2959,1523,2422,1378,3392,1134,339,1657,2312,340,2887,1046,1242,1942,1048,179,2472,632,2737,79,1069,2066,2917,2025,175,2815 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3430 Ventricular arrhythmia 14 43 3.0896006108422416 0.0020042581045813 O75306,P23786,P42892,O43772,Q9HD47,P36551,P03886,Q99959,P13473,P50402,Q14BN4,P10253,P00403,P12235 Drugs and Diseases Human Phenotype Ontology msigdb_hp 413,33,69,468,106,647,73,586,237,431,624,311,28,213 468,1874,413,2179,28,1534,73,858,1220,2597,1117,2965,311,213,237,1538,1743,2619,693,33,3167,647,2990,69,775,1258,1163,431,1891,2703,1670,1451,624,1863,2197,1043,1459,1624,937,586,1590,1087,106 0.9462000577616902,-0.1773059016141884,1.07084676596474,-0.31905629408571334,3.0698107589013315,-0.005591913085313469,2.4178172840822203,0.44626893355334946,0.17675834803240076,-0.596278947334594,0.24146991514915547,-0.9103121062691136,1.3246420617522143,1.641034754600386,1.554325783520826,-0.005591913085313469,-0.10791253841717666,-0.6153265492951593,0.6282990804246098,3.0318170762153325,-1.1599171531024435,0.6728169776242082,-0.9306276139125141,2.4496613605694386,0.5380910558331444,0.1604504658814682,0.20921739577808898,1.0296274822176772,-0.1773059016141884,-0.6729168790091554,-0.07357327446040215,0.04479749007284595,0.7022834886797121,-0.15986707294579158,-0.31905629408571334,0.30536674022651894,0.04479749007284595,-0.03946755021715677,0.3841256925736641,0.7461703883999292,-0.02250118346835699,0.2735187641595761,2.189571052524327 3430 Heterogeneous 12 47 3.077998480611757 0.0020839597760426 Q9BQE5,O75844,Q8TB36,P61916,P03886,Q9NR77,Q9Y619,P05067,Q13315,P01889,P12235,P21964 Drugs and Diseases Human Phenotype Ontology msigdb_hp 0,32,390,512,73,123,45,205,400,369,213,280 2318,1874,1637,32,3151,673,369,1534,73,1877,2225,205,2819,1254,1509,213,1743,280,1190,1781,2078,948,1541,1192,2509,524,2462,512,2046,400,2234,1451,1485,1374,1169,625,2867,390,2729,3404,2167,0,1006,123,1245,1531,45 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3.0770174788965243 0.0020908304040312 P51970,Q5JPH6,Q96CU9,Q9UBX3,Q7KZN9,Q70HW3,Q9Y2R0,O43676,Q9P0J0,O75306,Q86Y39,P21912,Q9Y6M9,O75648,Q9NPL8,P82663,P03886,P13073,O96000,Q9Y584 Drugs and Diseases Human Phenotype Ontology msigdb_hp 386,651,274,13,525,16,19,21,158,413,168,693,326,444,325,695,73,336,606,119 892,1950,21,2922,1441,413,978,1442,444,2033,606,73,2035,336,2639,1119,693,3031,3011,1747,1395,2507,3152,386,2669,2483,695,2995,1673,968,651,2092,16,525,168,1493,935,1459,274,1044,1865,2518,1408,816,1089,325,749,158,3124,13,19,2616,119,326 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3430 Liposaccharide metabolic process 8 18 3.065174743482805 0.002175428534697 O43292,P17900,P16278,P06865,O60512,P06280,P04062,Q8NBX0 Processes and pathways GO Biological process msigdb_gobp 194,66,43,268,18,275,30,95 194,18,605,30,895,275,268,1358,43,66,2511,988,95,1083,1378,2761,340,640 1.738437938975464,3.237676205824806,0.7169539114401163,3.0603364192521147,0.41529180787632924,1.4151493408700357,1.4279535786684734,0.09468784334280253,2.9065277890482055,2.4918352621956807,-0.5208177336190014,0.33701658189477507,2.244786155021276,0.2735187641595761,0.09468784334280253,-0.7116898323792509,1.2590315225380515,0.6875712647067221 3430 Alcohol metabolic process 25 87 3.0597862361984243 0.0022149502032637 Q9BQE5,O75874,P48735,P05091,Q06520,Q15392,Q14849,P04062,O15269,Q10713,P37268,Q8WTV0,P54646,P00374,P05067,Q16850,Q6NUM9,Q15800,Q14739,P16435,Q13510,P51648,O15118,Q14534,P35610 Processes and pathways GO Biological process msigdb_gobp 0,1,10,267,144,23,27,30,286,292,166,169,75,76,205,210,216,88,222,231,250,110,109,122,252 3416,109,286,295,3308,961,605,566,470,1,382,3338,2070,3389,76,1876,30,205,267,3301,3279,2697,2989,3141,231,1444,2799,1997,3376,928,2110,252,166,740,2776,556,753,10,1258,2991,1060,3310,2509,110,1855,3383,75,2081,3360,2266,512,2607,3426,3312,1450,144,292,250,3405,2234,3254,122,222,27,3220,23,1169,88,1720,210,3132,216,1457,1207,1175,169,2203,3387,3001,0,2492,1553,2065,632,2135,761,768 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3430 Abnormality of extrapyramidal motor function 18 75 3.054771734159477 0.0022523187516025 P17900,P07602,P98175,P16278,Q06787,P05067,Q9NZJ7,P35637,P06865,Q6DKK2,O75569,Q9Y4P3,P12235,Q99720,O14949,P35610,P04062,Q15043 Drugs and Diseases Human Phenotype Ontology msigdb_hp 66,38,281,43,203,205,341,235,268,82,342,313,213,26,155,252,30,191 155,2350,870,1441,342,3248,3045,1443,2618,30,205,2819,268,38,1358,3225,676,1535,213,43,1996,66,896,1415,2324,2354,784,2775,2110,252,235,447,2509,1713,2387,1290,2266,2879,281,2529,741,3054,203,2609,2418,1485,3228,191,2299,651,822,82,2610,2393,972,3158,358,937,885,3387,26,1179,1136,688,2521,2376,341,1529,866,3097,1216,2025,313,3043,1025 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3430 RNA recognition motif domain [IPR000504] 44 124 3.040273234071063 0.0023636360944392 Q14011,P78332,P14866,P52756,P11940,Q14103,Q01844,P98175,Q9BWF3,P98179,P51991,Q99729,Q13151,Q13595,Q01085,P07910,Q15427,Q9P2N5,Q96DH6,O60506,A0AV96,P52597,O43390,P55795,P62995,P31483,Q9UKA9,P23246,P43243,Q96EP5,P31943,P26368,Q9UKM9,P22626,P31942,P23588,Q92804,P38159,Q76FK4,P35637,Q96PK6,O14979,Q9UHX1,Q01081 Sequence InterPro Domain interpro_domain 636,650,772,395,394,149,282,281,411,419,297,170,426,301,558,675,312,183,700,187,690,318,195,196,576,322,460,584,585,720,200,710,733,343,217,724,223,351,481,235,493,108,118,755 690,1949,108,1070,1849,195,2692,187,1282,3125,1810,783,3249,675,3083,1286,1315,981,394,772,2746,2638,343,584,724,710,2527,322,217,200,2077,235,351,2551,585,1512,297,1012,1667,318,395,196,2415,576,650,1449,281,419,755,558,282,3244,1397,2822,2188,2418,426,1167,2047,2935,2880,1336,301,636,149,1617,1230,1125,1858,2299,1078,1168,878,312,1452,2049,3038,2652,1895,481,2274,2755,1680,1862,1492,1828,879,1341,2489,1522,999,2239,1042,223,1343,700,720,1500,493,1758,2312,170,3057,411,1157,1687,3333,2427,2209,2570,1245,2169,1308,183,118,460,733,1989,3079,1846,867,836,2281,1140 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3430 Localized skin lesion 54 230 3.036887075547787 0.0023903498675952 Q7LGA3,Q06136,O75874,P61978,P38435,P48735,O15460,P16615,Q13315,P06280,O95202,Q6DKJ4,Q15392,P21964,P04062,O75844,O15269,Q15022,O43683,P07602,P53701,O15270,Q9Y619,Q9NWM8,Q15427,Q9Y4P3,Q9NZ08,P42858,O75648,Q06787,O15360,P61586,Q9NZJ7,Q9UL01,Q96L58,Q96PU5,O96028,Q03519,Q03518,Q8IZA0,Q14739,P42345,Q8TAA9,Q96AY3,P48651,Q6ZXV5,Q6PGP7,P35637,P01889,Q13126,Q96PZ0,Q96MF7,Q9UHX1,Q13510 Drugs and Diseases Human Phenotype Ontology msigdb_hp 128,258,1,387,136,10,398,269,400,275,401,406,23,280,30,32,286,542,539,38,167,295,45,179,312,313,185,447,444,203,454,337,341,79,339,211,334,215,218,93,222,353,482,357,360,233,480,235,369,113,498,507,118,250 2173,1472,3401,1438,1738,2407,286,295,454,398,926,1328,3060,1439,539,2987,2350,961,837,1874,1097,1009,1473,1776,2409,3007,3300,2574,1010,1638,444,2818,32,1,1533,1777,401,2743,1414,927,2595,334,1951,369,1534,858,30,1877,2949,275,2526,38,1954,1145,1189,1535,3340,1743,269,2109,3303,896,1880,1415,3191,3127,2073,693,280,2859,3163,2457,1850,738,897,2800,1813,928,1190,2775,235,3068,2413,647,2078,136,3050,2111,1710,353,447,1884,2001,2749,2778,360,10,796,2991,1163,805,1120,2953,167,2670,2326,2623,821,574,1290,2292,2862,337,387,2043,2992,2555,2879,1513,609,1198,1450,1891,2934,1296,2703,807,218,215,741,2364,2511,2556,258,203,1578,1297,2045,550,1921,113,400,2626,2973,250,2235,1322,1671,222,542,2825,2299,3220,1821,1078,2237,23,312,2439,1374,2366,2676,2725,406,580,744,2867,480,233,128,1795,1796,3313,93,2010,2276,3355,2395,482,2872,1497,2057,612,1131,2729,2422,2241,1834,357,339,507,211,498,2761,1380,2312,885,2124,1046,1242,1048,2685,1138,2370,1763,1307,3371,1903,2022,2209,179,2472,2376,185,341,1092,3397,118,866,79,2875,668,2139,2066,2572,1470,1633,313,2281,45 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3430 Increased susceptibility to fractures 14 59 3.035596813032289 0.0024006014043573 O75874,Q32P28,O15269,Q96AY3,P16435,P48735,O15270,Q96L58,Q13126,P22626,O75718,Q14108,Q14739,P04062 Drugs and Diseases Human Phenotype Ontology msigdb_hp 1,34,286,357,231,10,295,339,113,343,89,60,222,30 2107,286,295,376,1776,89,470,1,2897,2179,1414,3151,30,1877,3232,2526,2819,1284,981,1189,231,2109,3303,343,3163,3328,1813,1190,2111,1710,10,524,2821,2387,1450,2364,1968,2045,113,1646,60,2114,222,34,2725,1497,357,339,1463,1046,3172,2735,2370,2472,1092,761,2139,2170,1470 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3430 Regulation of hormone levels 14 68 3.031404465227541 0.0024341893681187 O75844,P30536,Q53GQ0,P42892,Q9HB40,P16435,Q06520,P53985,Q15907,P04083,Q6NUM9,O95470,Q14849,Q15043 Processes and pathways GO Biological process msigdb_gobp 32,2,262,69,40,231,144,271,276,148,216,86,27,191 857,1948,2796,1774,1354,1161,2256,32,3338,1639,86,839,673,858,148,607,2548,2148,3141,231,2637,316,2,3166,948,740,69,3169,1058,1194,1011,271,3182,2081,2004,1918,2556,144,2993,1337,27,191,2190,276,1720,625,262,216,2335,2054,996,1493,515,1207,1623,1130,1175,1499,1380,2205,3387,1837,40,1092,632,3097,1632,768 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3430 Variable expressivity 14 80 3.0286382377229115 0.0024565865763777 P17900,P07602,Q6P4A7,P03886,Q9H061,P00374,O76031,Q70HW3,O95470,Q9NWS8,Q15427,Q13510,Q9NR77,P00403 Drugs and Diseases Human Phenotype Ontology msigdb_hp 66,38,232,73,12,76,251,16,86,182,312,250,123,28 892,1948,1559,3418,781,605,3149,251,1414,86,76,28,1534,73,445,2819,1254,38,2548,1568,676,66,1960,2110,2748,3051,1884,585,775,2967,1886,2361,1120,1713,2387,3114,1195,2529,1783,2608,1968,2045,3296,250,949,1616,623,1202,312,951,810,2092,822,232,1104,16,920,935,639,2729,1459,1241,904,1005,940,12,1660,850,2983,123,182,341,1051,955,1216,1350,1280,2025,1025,1698 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3430 Abnormality of femur morphology 21 74 3.027215654979471 0.0024681780277044 Q7LGA3,P06280,P04062,O95831,O75844,Q32P28,P07602,P16278,Q9Y619,Q9Y487,Q6NUQ1,Q9NZJ7,Q96L58,O75718,Q14739,Q96AY3,P16435,Q9UHX1,Q96HY6,Q96A33,O60568 Drugs and Diseases Human Phenotype Ontology msigdb_hp 128,275,30,414,32,34,38,43,45,175,452,341,339,89,222,357,231,118,380,379,376 1184,1389,2107,977,1438,454,837,376,2574,1010,89,32,2223,927,414,3151,1534,30,895,1877,275,3232,38,1256,43,231,3127,2262,2800,3049,2078,3050,3402,2290,2079,524,619,2483,574,2862,222,2091,1486,34,452,2845,128,2677,2959,1079,2872,2729,379,357,2308,380,339,1657,779,2123,1242,2735,3371,2963,2022,341,1092,118,2875,2170,2917,175,2281,45 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3430 Tclin 31 87 3.02500654351712 0.0024862774817395 P51970,P38435,P48735,P05091,Q07864,P49721,O95168,P06280,Q9UBN7,O43676,Q99720,P21964,Q9P0J0,O75306,Q86Y39,O75438,P20618,P10253,P07437,P04350,Q9Y6M9,P55011,P03886,P00374,P31350,P42345,Q9P032,P05023,O96000,Q9Y2I1,Q13885 Drugs and Diseases Pharos IDG Category pharos_protein_category 386,136,10,267,788,142,529,275,666,21,26,280,158,413,168,671,437,311,310,445,326,574,73,76,711,353,749,607,606,633,623 892,1950,21,2922,2379,1441,413,978,671,1442,529,3008,2033,606,76,980,3027,73,858,445,1811,607,267,1607,275,310,2034,2036,2431,2965,311,3009,1256,1741,1779,1535,2666,2697,3141,2639,437,280,2698,1287,3181,1851,1881,3031,897,711,2413,136,353,10,142,3152,2040,1963,386,1574,574,787,1918,2934,2511,863,788,1483,1123,623,3131,1673,2784,168,1493,2536,26,1552,2518,1241,1005,749,158,666,1736,633,326 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3430 Decreased activity of mitochondrial complex i 11 36 3.0223172073454365 0.0025084753264377 O75306,P51970,Q9Y6M9,Q9NPL8,Q86Y39,P03886,Q96CU9,Q9UBX3,Q70HW3,O43676,Q9Y584 Drugs and Diseases Human Phenotype Ontology msigdb_hp 413,386,326,325,168,73,274,13,16,21,119 892,21,1441,413,978,1442,444,606,73,2639,3031,2507,3152,386,2669,2483,651,2092,16,168,1493,935,1459,274,1044,1865,2518,1408,816,1089,325,749,13,2616,119,326 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3430 Limb joint contracture 23 104 3.0161061731970737 0.002560435875949 Q7LGA3,Q6DKJ4,Q15392,Q99720,Q86XL3,O75844,P23786,P49902,P37268,Q99567,Q9Y619,P42892,Q96L58,Q13535,Q8IZA0,Q96AY3,P16435,P48651,P35637,Q9NR77,O60313,O60568,Q14738 Drugs and Diseases Human Phenotype Ontology msigdb_hp 128,406,23,26,161,32,33,160,166,42,45,69,339,338,93,357,231,360,235,123,375,376,254 1948,1389,1437,2107,2816,1438,2174,3060,837,2217,375,376,605,2143,1356,566,32,2070,1777,3286,1534,2819,1254,1256,1538,1743,231,896,3127,693,2859,33,738,2800,1747,1813,235,2149,166,2111,3234,69,3402,360,160,431,2079,2509,821,3129,1195,1815,1450,1296,2608,1297,338,2235,1670,2113,254,2091,542,1488,1821,23,1676,406,2051,128,161,919,93,1494,2565,639,1833,1043,3346,2120,357,339,2312,42,26,2123,1087,2279,2540,1763,3424,850,123,2875,1349,2170,2896,1436,1847,2741,1698,3388,45,2172 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3430 Biliary tract abnormality 12 29 3.013119782187138 0.002585768343299 Q10713,P07602,Q9NZJ7,Q5XKP0,O43681,O95202,Q9UJW0,O96028,P09601,Q14108,Q14739,P04062 Drugs and Diseases Human Phenotype Ontology msigdb_hp 292,38,341,626,553,401,180,334,59,60,222,30 869,553,401,334,1534,30,38,59,1223,983,2353,804,2699,2079,1194,292,1857,2626,60,222,626,1834,685,1346,341,1023,180,1350,2815 0.43080383738421585,0.7896879996375533,1.0981470112960925,1.2590315225380515,-0.005591913085313469,3.0603364192521147,3.0127233121243298,2.54410242985927,0.17675834803240076,0.33701658189477507,-0.40974773902190176,0.4923857069491886,-0.6729168790091554,-0.26542599868242417,0.19301386899346543,1.3765499068522848,-0.15986707294579158,-0.6153265492951593,2.5336885717746562,1.6164042064007391,0.7022834886797121,-0.1424888753229872,0.6431811538013191,0.11120892157867891,1.2590315225380515,0.32121625895525563,1.798428045397234,0.11120892157867891,-0.7507725016906376 3430 Lipid catabolic process 31 87 3.005457839436662 0.0026518135615285 O75874,O14678,Q9NP80,O14734,Q06520,P06865,P06280,Q16134,P50897,Q8NCG7,O15254,P04062,P23786,Q8N2A8,O14975,Q8WTV0,Q9BWD1,P28288,Q8NHP8,A1L0T0,Q15067,Q2T9J0,P17900,O43808,Q709F0,Q99519,O95470,Q8NCC3,A8MXV4,Q13510,P35610 Processes and pathways GO Biological process msigdb_gobp 1,257,264,391,144,268,275,533,22,534,285,30,33,164,424,169,304,555,53,54,319,320,66,573,457,340,86,91,350,250,252 54,350,3427,257,391,424,285,573,2381,1,3323,86,30,895,3421,1606,275,268,1358,3287,3358,1535,3028,1444,66,2504,2261,33,2354,2434,555,3344,3011,252,3168,2183,948,740,929,2776,1884,1258,1058,2079,22,1364,1194,2510,2837,2187,2511,144,1968,1969,250,319,2391,533,1720,625,320,3291,2193,457,1172,1128,164,1494,1457,1623,91,534,53,169,2338,340,1837,1085,1047,3422,304,2128,264,3173,591,1386,2660 2.6267135515683826,1.2325569767034361,-4.650483787176411,1.4661818634308703,1.125305736257329,1.04340337414266,1.3894476706931538,0.7607169539788241,-0.4280869276823581,3.92901774642917,-1.6306790060749776,2.321161071650228,3.0603364192521147,0.41529180787632924,-3.7873509360750597,-0.03946755021715677,1.4151493408700357,1.4279535786684734,0.09468784334280253,-1.4913543909405875,-1.8477085071425041,-0.005591913085313469,-0.971515740451046,0.04479749007284595,2.4918352621956807,-0.5208177336190014,-0.35513411913799386,3.0318170762153325,-0.40974773902190176,-0.4649705794159142,0.7896879996375533,-1.7500104946959263,-0.9510285615071858,1.4915153034770001,-1.1599171531024435,-0.31905629408571334,0.36847097049977656,0.5833929390939195,0.3841256925736641,-0.7311921139115007,-0.1773059016141884,0.1604504658814682,0.2894676887918951,-0.26542599868242417,3.191546309151074,0.09468784334280253,0.19301386899346543,-0.5208177336190014,-0.7901703605422196,-0.31905629408571334,-0.5208177336190014,1.9513415899455118,-0.2123673195994045,-0.2123673195994045,1.5041368739934033,1.2984956621256847,-0.4280869276823581,0.8328430643605732,-0.0907134950668146,0.7022834886797121,1.2984956621256847,-1.4913543909405875,-0.31905629408571334,0.9741576934609325,0.20921739577808898,0.24146991514915547,1.8577557582221775,0.02805701137235168,0.04479749007284595,-0.03946755021715677,2.277649032464161,0.8328430643605732,2.6369536602330523,1.8459424393187207,-0.3914762369552328,1.2590315225380515,-0.1424888753229872,0.2735187641595761,0.30536674022651894,-3.980876334866757,1.3506596827179598,-0.2832385860448953,1.4534696782308594,-1.1599171531024435,0.7461703883999292,0.09468784334280253,-0.6344483133432426 3430 Organophosphate ester transport 14 25 3.003749131672892 0.002666751157303 Q6NUK1,P08183,P12236,Q4KMQ2,Q9BZF1,P61916,Q8WTV0,Q14108,Q9H2D1,Q8TB61,P12235,P22059,Q9BSK2,Q96GC9 Processes and pathways GO Biological process msigdb_gobp 580,159,418,163,458,512,169,60,49,55,213,316,61,188 2796,573,736,159,213,418,316,2261,1914,512,2511,60,163,580,730,996,55,169,188,1552,61,458,3380,49,1734 -0.7507725016906376,0.7607169539788241,0.5833929390939195,1.8695432160167267,1.641034754600386,1.057143066123191,1.2984956621256847,-0.35513411913799386,-0.1948058268211105,0.8756421363992508,-0.5208177336190014,2.5336885717746562,1.8577557582221775,0.7607169539788241,0.5984052493734849,0.33701658189477507,2.606176282501621,1.8459424393187207,1.7625145060761207,-0.005591913085313469,2.5336885717746562,0.9741576934609325,-2.049460345691425,2.7383268943293446,-0.0907134950668146 3430 Sphingolipid biosynthetic process 9 15 2.992748982141366 0.0027647704545619 Q06136,O15269,Q9P035,O15270,O60512,O95470,Q13510,Q96G23,P04062 Processes and pathways GO Biological process msigdb_gobp 258,286,294,295,18,86,250,124,30 286,295,18,86,30,316,501,2511,258,250,951,124,591,294,1734 1.3894476706931538,1.3636206339195902,3.237676205824806,2.321161071650228,3.0603364192521147,1.2984956621256847,0.8898304908049921,-0.5208177336190014,1.4661818634308703,1.5041368739934033,0.36847097049977656,2.066089721766653,0.7461703883999292,1.3765499068522848,-0.0907134950668146 3430 Mitochondrial myopathy 10 28 2.9878788675407115 0.0028092087034132 Q9Y6M9,Q9NPL8,Q9NP80,Q86Y39,P03886,Q96CU9,O43676,P12235,O60313,P00403 Drugs and Diseases Human Phenotype Ontology msigdb_hp 326,325,264,168,73,274,21,213,375,28 892,21,375,1441,413,978,1442,606,28,73,213,2639,3031,3152,951,168,1493,935,274,937,2518,1212,264,325,749,2024,1601,326 0.41529180787632924,3.200802504118346,1.1657819605638418,0.04479749007284595,1.07084676596474,0.33701658189477507,0.04479749007284595,0.7169539114401163,3.0698107589013315,2.4178172840822203,1.641034754600386,-0.6344483133432426,-0.971515740451046,-1.1386163266404463,0.36847097049977656,1.8459424393187207,0.02805701137235168,0.3841256925736641,1.4279535786684734,0.3841256925736641,-0.5208177336190014,0.19301386899346543,1.4534696782308594,1.2853737321434007,0.5833929390939195,-0.22999085661134913,-0.02250118346835699,1.2853737321434007 3430 Meiotic cell cycle process 19 46 2.9878485845858385 0.0028094870547488 P46379,Q14674,O14965,Q13315,O14777,P30153,Q9Y5A9,O43683,Q12768,Q9BZD4,Q96GX5,Q9Y2W6,P42695,O15360,O95067,Q92791,Q9BTX1,O94901,P53350 Processes and pathways GO Biological process msigdb_gobp 256,637,521,400,528,795,817,539,550,422,684,48,439,454,709,219,92,368,502 528,521,454,539,2283,1097,1185,368,709,1778,1779,3064,795,3086,1416,1911,439,256,2361,805,502,1573,2671,2463,2005,914,1297,550,400,637,1719,1487,2366,1376,1172,219,1683,684,92,1242,422,1689,1595,2916,48,817 0.8471486580863727,0.861414936766202,0.9741576934609325,0.8184979173823138,-0.373271876429598,0.25751962221115077,0.19301386899346543,1.179204988513675,0.6133738705970863,-0.12517084870498654,-0.12517084870498654,-1.0127520150653435,0.5076661391022604,-1.0335027512907717,0.06148252180205109,-0.1948058268211105,1.0158151806848401,1.47886368568901,-0.40974773902190176,0.4923857069491886,0.8898304908049921,-0.02250118346835699,-0.6536448751928122,-0.4835161673691688,-0.22999085661134913,0.3997325317718629,0.14408985151272588,0.8041129767098191,1.1117439633053623,0.6875712647067221,-0.0907134950668146,0.02805701137235168,-0.40974773902190176,0.09468784334280253,0.20921739577808898,1.6287336796515217,-0.07357327446040215,0.6431811538013191,2.277649032464161,0.17675834803240076,1.057143066123191,-0.07357327446040215,-0.02250118346835699,-0.8498704751461239,2.748363067010926,0.4923857069491886 3430 Alternative mrna splicing via spliceosome 18 45 2.987438176286405 0.002813261882433 Q00839,P62995,P31483,P52756,P14866,P17844,P23246,Q06787,P51116,O95391,P51114,Q08211,Q96MU7,Q9UHX1,P98175,Q9BWF3,Q07666,P38159 Processes and pathways GO Biological process msigdb_gobp 609,576,322,395,772,773,584,203,100,234,84,622,664,118,281,411,448,351 3138,2663,2143,1810,234,981,772,773,584,2527,322,351,1512,84,100,1012,395,576,281,609,203,448,1397,622,2417,1167,2935,1423,2189,1168,1518,1492,1341,881,1343,1500,664,1758,411,2064,118,957,2544,836,2281 -1.117409393747407,-0.6536448751928122,-0.30111518243997987,-0.1424888753229872,1.5667994320520733,0.33701658189477507,0.5380910558331444,0.5380910558331444,0.7461703883999292,-0.5395748804972572,1.2853737321434007,1.2325569767034361,0.01126068031324202,2.3319852246797077,2.211724229893288,0.32121625895525563,1.125305736257329,0.7607169539788241,1.402314093228658,0.7169539114401163,1.7021191193583658,1.001966258000303,0.07811250742307049,0.7022834886797121,-0.4464943548499513,0.20921739577808898,-0.8699343008139493,0.06148252180205109,-0.31905629408571334,0.20921739577808898,0.01126068031324202,0.02805701137235168,0.11120892157867891,0.43080383738421585,0.11120892157867891,0.02805701137235168,0.65802036299361,-0.10791253841717666,1.0845146796370766,-0.24767692023999524,2.1113172784145564,0.36847097049977656,-0.5395748804972572,0.47705956297724367,-0.35513411913799386 3430 Sterol binding 11 18 2.9823750100588384 0.0028602141130187 P30536,Q9BZF1,P61916,P21796,Q96SU4,P45880,O15118,P35610,P22059,Q14849,Q14108 Functions GO Molecular function msigdb_gomf 2,458,512,9,564,15,109,252,316,27,60 109,566,2070,2146,9,316,2261,2,252,15,512,60,27,564,1591,1553,458,3380 2.1784605959005607,0.7752227411673067,-0.26542599868242417,-0.30111518243997987,3.489279818123242,1.2984956621256847,-0.35513411913799386,3.92901774642917,1.4915153034770001,3.2925394092933984,0.8756421363992508,2.5336885717746562,3.0792691433168833,0.7896879996375533,-0.02250118346835699,-0.005591913085313469,0.9741576934609325,-2.049460345691425 3430 Abnormality of pulmonary circulation 14 31 2.980423722364932 0.0028784991595782 O75844,Q6NUK1,P51970,O14678,O96000,P03886,P51798,P14854,P01889,Q8IZA0,Q9NZ08,Q14108,P00403,P04062 Drugs and Diseases Human Phenotype Ontology msigdb_hp 32,580,386,257,606,73,524,363,369,93,185,60,28,30 257,2145,32,1390,606,28,369,1534,73,30,1255,363,1119,3127,2073,2925,2000,1541,796,524,386,60,3275,680,2676,580,93,1624,2132,185,3043 1.4661818634308703,-0.30111518243997987,3.050846065270086,0.07811250742307049,0.7169539114401163,3.0698107589013315,1.179204988513675,-0.005591913085313469,2.4178172840822203,3.0603364192521147,0.1604504658814682,1.1925938145223307,0.24146991514915547,-1.096295452188383,-0.26542599868242417,-0.8699343008139493,-0.22999085661134913,-0.005591913085313469,0.5076661391022604,0.861414936766202,1.1388325289942267,2.5336885717746562,-1.445808727840182,0.6431811538013191,-0.6536448751928122,0.7607169539788241,2.2667166943530197,-0.03946755021715677,-0.2832385860448953,1.774512395985724,-0.971515740451046 3430 Organic acid transmembrane transporter activity 11 19 2.9777413775247585 0.0029038089481208 O75746,P08183,O14975,Q9UBX3,Q9Y619,P53985,Q9H2D1,Q9UJS0,P30825,Q96NB2,Q9BQT8 Functions GO Molecular function msigdb_gomf 692,159,424,13,45,271,49,708,402,410,157 424,692,839,159,1567,402,1100,271,696,950,2193,410,157,49,1409,942,13,708,45 1.04340337414266,0.6282990804246098,0.4616874064468927,1.8695432160167267,-0.02250118346835699,1.0981470112960925,0.25751962221115077,1.4279535786684734,0.6282990804246098,0.36847097049977656,-0.31905629408571334,1.0845146796370766,1.8813049364421908,2.7383268943293446,0.07811250742307049,0.3841256925736641,3.391761695054266,0.6282990804246098,2.7982738550861823 3430 Protein transporter activity 6 15 2.9770102167987877 0.0029107431004171 Q9Y5J9,Q9HD20,Q9NS69,Q99595,O60830,Q9Y584 Functions GO Molecular function msigdb_gomf 193,35,7,78,20,119 204,20,1098,1443,910,1014,621,900,1040,78,35,7,547,119,193 1.6777690135569574,3.2100435371001237,0.25751962221115077,0.04479749007284595,0.3997325317718629,0.32121625895525563,0.7022834886797121,0.41529180787632924,0.30536674022651894,2.3750691920218543,3.0318170762153325,3.602417135580486,0.8184979173823138,2.1113172784145564,1.750489731196436 3430 Glycosphingolipid metabolism 9 16 2.9750984203523823 0.002928945598049 P10619,P17900,P07602,P16278,Q9NZJ7,P06865,P06280,Q13510,P04062 Processes and pathways Reactome Pathways msigdb_reactome 226,66,38,43,341,268,275,250,30 856,553,30,275,268,38,1358,226,983,43,66,250,340,2830,591,341 0.44626893355334946,0.7896879996375533,3.0603364192521147,1.4151493408700357,1.4279535786684734,3.0127233121243298,0.09468784334280253,1.6040461907838122,0.33701658189477507,2.9065277890482055,2.4918352621956807,1.5041368739934033,1.2590315225380515,-0.7704316844994457,0.7461703883999292,1.2590315225380515 3430 Endocytic vesicle 20 86 2.971971484985489 0.0029589416410409 P10321,Q15907,Q14457,O00461,Q8WTV0,P33176,P14625,Q9Y487,Q14108,Q969Q5,Q5VYK3,P08670,Q03519,Q16625,Q03518,Q93050,P42345,P13473,P01889,P04439 Localization GO Cellular component msigdb_gocc 393,276,287,31,169,425,300,175,60,323,71,335,215,346,218,220,353,237,369,244 1737,857,31,907,1071,926,3179,2574,1186,2071,1702,369,1314,244,1221,656,335,3126,3233,393,982,646,1509,1994,237,300,1147,3064,2641,2076,425,353,1192,912,2461,1364,3206,1011,986,2292,2644,1292,1149,2186,1259,3341,2804,1783,1450,218,215,1578,1422,2704,1337,1669,60,1321,287,2390,2330,1583,2237,276,2628,346,1674,449,71,2335,902,169,3074,220,323,1270,1272,588,2520,2875,1348,956,175,734,2405,2214 -0.10791253841717666,0.44626893355334946,3.050846065270086,0.3997325317718629,0.2735187641595761,0.3841256925736641,-1.1813127889529935,-0.5773048800496771,0.19301386899346543,-0.26542599868242417,-0.0907134950668146,1.179204988513675,0.1276761298241045,1.5292904957224467,0.17675834803240076,0.65802036299361,1.2590315225380515,-1.096295452188383,-1.3117306703903504,1.125305736257329,0.33701658189477507,0.6728169776242082,0.01126068031324202,-0.22999085661134913,1.554325783520826,1.3506596827179598,0.22536929144369766,-1.0127520150653435,-0.6344483133432426,-0.26542599868242417,1.04340337414266,1.2192696206606266,0.19301386899346543,0.3997325317718629,-0.4835161673691688,0.09468784334280253,-1.2460779206914567,0.32121625895525563,0.33701658189477507,-0.373271876429598,-0.6344483133432426,0.14408985151272588,0.22536929144369766,-0.31905629408571334,0.1604504658814682,-1.725900749051077,-0.7507725016906376,-0.12517084870498654,0.04479749007284595,1.6287336796515217,1.641034754600386,-0.02250118346835699,0.06148252180205109,-0.6729168790091554,0.11120892157867891,-0.07357327446040215,2.5336885717746562,0.1276761298241045,1.3894476706931538,-0.4280869276823581,-0.3914762369552328,-0.02250118346835699,-0.33706243340680064,1.4151493408700357,-0.6153265492951593,1.2458108826688405,-0.07357327446040215,1.001966258000303,2.4390671593224433,-0.3914762369552328,0.41529180787632924,1.8459424393187207,-1.0127520150653435,1.6287336796515217,1.2853737321434007,0.1604504658814682,0.1604504658814682,0.7461703883999292,-0.5208177336190014,-0.8099892376198776,0.11120892157867891,0.36847097049977656,1.8103460646896083,0.5984052493734849,-0.4280869276823581,-0.31905629408571334 3430 Response to oxidative stress 26 103 2.968757459515673 0.0029900650095622 O75874,Q9NP80,Q15165,O43169,P16615,Q8N0U8,O95168,Q16134,P04083,Q15392,Q99720,P04062,Q14457,O95831,O75306,P30519,Q969S3,Q9Y5Z4,P46108,P09601,Q6NUK1,Q15118,P54646,P00374,P05067,O75569 Processes and pathways GO Biological process msigdb_gobp 1,264,139,14,269,17,529,533,148,23,26,30,287,414,413,44,560,50,429,59,580,329,75,76,205,342 2876,892,2816,1738,14,413,2284,2547,342,1,1507,529,1703,414,76,980,30,148,3161,1877,2225,205,2525,1608,1284,1117,59,2036,2147,3301,2856,269,3257,896,1569,1415,584,2771,3048,774,1881,2800,3344,2356,2181,2598,44,3251,1813,1190,2506,804,2000,820,429,2699,2360,3282,1012,75,2153,3194,1165,2511,621,931,899,1228,1647,287,329,139,1078,23,533,580,1546,1425,1172,17,2565,827,2536,560,1000,3000,1499,2849,2470,1380,2243,3387,26,1242,1688,264,705,2494,1245,1308,666,2137,50 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3430 Lipid binding 26 156 2.9683359546224515 0.0029941687764933 Q9BQE5,P30536,P21796,P38435,O00560,P45880,O00264,P50897,P04083,Q14849,O15254,P04062,O14773,P07602,Q8WTV0,Q9UM22,Q14108,P22059,A6NIH7,Q15067,O43292,Q96L92,Q8NCC3,O15173,O15118,P35610 Functions GO Molecular function msigdb_gomf 0,2,9,136,266,15,143,22,148,27,285,30,162,38,169,51,60,316,62,319,194,330,91,99,109,252 856,62,143,1662,1559,1389,266,2796,162,907,794,109,99,285,2767,194,960,375,3179,1699,1355,2455,1603,566,3338,2070,2071,2032,1639,30,148,607,1952,38,2596,2146,1359,2768,3180,2108,2411,1222,1509,3279,1994,1477,2073,9,316,2261,3181,2287,2640,841,3101,2,1479,3167,252,1572,136,15,2749,1511,1914,22,912,3033,2929,1964,1573,2387,1750,512,1714,2607,1198,2648,988,503,3035,1422,531,427,1201,2704,2089,3015,60,2155,27,2389,319,3130,1583,3245,1896,2116,2097,2868,2275,1681,2678,91,2468,169,1082,1083,1977,2730,1427,1270,2758,330,2684,564,1937,848,517,2887,3209,3205,0,2830,887,1591,1553,458,1555,3380,640,748,815,1382,2892,341,1214,2104,3278,1530,2250,51,3375,2689,1632,2315,633,3222,2919,734,2317,891,2140,670,924,1558 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3430 Abnormal myocardium morphology 41 186 2.9674040095651497 0.0030032604289145 P48735,Q9H061,Q96CU9,Q13423,P06280,O43676,P08236,P00403,Q9P0J0,P04062,O75306,P23786,Q99797,P53701,Q86Y39,P16278,P50402,Q9NWS8,Q9Y4P3,P10253,Q9NZ08,Q9NVI7,Q14108,Q9Y6M9,Q9NPL8,P03886,O15360,P15586,Q99519,P54802,P12235,Q00325,P22626,O43772,Q9Y2Z2,O76024,Q96RL7,P13473,P14854,P01889,O60313 Drugs and Diseases Human Phenotype Ontology msigdb_hp 10,12,274,146,275,21,279,28,158,30,413,33,290,167,168,43,431,182,313,311,185,443,60,326,325,73,454,206,340,87,213,214,343,468,488,477,358,237,363,369,375 906,2173,892,1950,454,21,2922,2350,468,1142,375,1441,413,978,1056,1442,3248,477,1777,1390,2033,1252,3286,606,28,369,1534,73,858,30,3421,1606,275,1566,2819,279,2035,723,1117,1568,981,311,213,237,1475,363,1538,206,1743,43,3010,896,3029,2639,1415,2073,693,1665,343,3062,33,2772,3031,3049,3011,1747,1478,2775,1224,3167,2926,2413,2990,2078,2748,1710,739,948,786,1148,1395,2507,775,1075,10,796,1258,3152,431,1058,2079,2483,167,87,2387,2510,1290,1195,3360,2862,2992,2879,1034,2484,214,1891,2934,741,2556,742,146,3071,1670,60,1451,3275,2113,2299,1078,1673,625,3132,951,1262,822,626,525,1171,1620,168,3313,1493,1206,2197,935,2872,1043,1834,1378,1459,1624,274,972,358,937,2312,340,1837,290,586,3041,1325,494,1087,2518,1242,3377,1942,12,1179,1408,1730,3262,816,1660,850,3371,325,2022,443,182,2133,185,749,158,866,2712,1350,488,2024,2917,2025,313,3043,1698,326 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3430 Steroid biosynthetic process 21 49 2.966983938555446 0.0030073666880687 P30536,Q53GQ0,O14734,Q15392,Q14849,P37268,O14975,Q96SU4,P28288,O75477,P22059,P54646,Q16850,O75845,Q15800,Q14739,P05023,P16435,Q14534,Q13510,O76062 Processes and pathways GO Biological process msigdb_gobp 2,262,391,23,27,166,424,564,555,566,316,75,210,470,88,222,607,231,122,250,382 391,424,566,470,382,2070,1876,607,3301,2697,3141,231,316,2261,1997,555,2,166,2776,753,1855,3383,75,2081,3312,250,3254,122,222,27,3220,23,1299,2190,1169,88,210,262,1623,3000,564,1837,2128,1553,3380,1659,632,767,760 1.125305736257329,1.04340337414266,0.7752227411673067,0.9462000577616902,1.1523245386286525,-0.26542599868242417,-0.1773059016141884,0.7169539114401163,-1.5373416114687155,-0.6729168790091554,-1.117409393747407,1.5792439505261,1.2984956621256847,-0.35513411913799386,-0.22999085661134913,0.7896879996375533,3.92901774642917,1.8459424393187207,-0.7311921139115007,0.5683366593475094,-0.15986707294579158,-2.0753063910430853,2.4071614359087854,-0.26542599868242417,-1.5605037593216007,1.5041368739934033,-1.3560056220962575,2.077431989617715,1.6164042064007391,3.0792691433168833,-1.267862233870033,3.1543688124281597,0.14408985151272588,-0.31905629408571334,0.20921739577808898,2.310315469590055,1.6655522802639968,1.4534696782308594,-0.03946755021715677,-0.9306276139125141,0.7896879996375533,-0.1424888753229872,-0.2832385860448953,-0.005591913085313469,-2.049460345691425,-0.0564914375226667,0.7022834886797121,0.5532361269354006,0.5683366593475094 3430 Hexosyltransferase activity 21 36 2.9655164853955145 0.0030217514985186 P46976,P06865,O60512,P04062,Q2TAA5,Q8N4A0,P46977,Q10472,Q96L58,O43909,O60762,Q6ZXV5,Q04446,Q9BT22,P04844,Q8TCJ2,Q13126,Q8NAT1,P04843,O43505,O60568 Functions GO Molecular function msigdb_gomf 775,268,18,30,288,172,430,456,339,837,605,233,741,494,362,628,113,115,872,752,376 2107,2767,752,837,18,376,605,1356,30,872,362,1566,268,1358,1955,1475,1224,775,430,1296,741,875,456,113,288,233,1723,172,115,1266,628,339,494,1138,3424,1556 -0.2832385860448953,-0.7311921139115007,0.5683366593475094,0.4616874064468927,3.237676205824806,1.1657819605638418,0.7169539114401163,0.09468784334280253,3.0603364192521147,0.43080383738421585,1.1925938145223307,-0.02250118346835699,1.4279535786684734,0.09468784334280253,-0.2123673195994045,0.02805701137235168,0.17675834803240076,0.5380910558331444,1.0296274822176772,0.14408985151272588,0.5833929390939195,0.43080383738421585,0.9741576934609325,2.167327425815136,1.3894476706931538,1.5792439505261,-0.0907134950668146,1.8341031346457968,2.156171440265243,0.1604504658814682,0.7022834886797121,1.2590315225380515,0.9180915884762,0.24146991514915547,-4.1411192303358,-0.005591913085313469 3430 Nuclear inner membrane 12 23 2.963382369677396 0.0030427833405677 O75844,O76062,P62995,P43243,Q9H1E5,Q9UH99,P50402,O94901,Q99720,Q8IXM6,Q14739,Q14728 Localization GO Cellular component msigdb_gocc 32,382,576,585,171,434,431,368,26,156,222,638 32,382,368,1446,1395,585,431,2267,576,1227,1200,638,222,1676,661,156,2959,3000,26,1087,171,434,1470 3.050846065270086,1.1523245386286525,1.179204988513675,0.04479749007284595,0.07811250742307049,0.7461703883999292,1.0296274822176772,-0.35513411913799386,0.7607169539788241,0.17675834803240076,0.19301386899346543,0.6875712647067221,1.6164042064007391,-0.07357327446040215,0.65802036299361,1.8813049364421908,-0.8900812583352817,-0.9306276139125141,3.107549151128594,0.2735187641595761,1.8459424393187207,1.0296274822176772,0.04479749007284595 3430 Aminoglycan metabolic process 7 15 2.960659887404953 0.0030698073526831 Q7LGA3,P16278,P15586,Q9UL01,P06865,P54802,P08236 Processes and pathways GO Biological process msigdb_gobp 128,43,206,79,268,87,279 752,2546,1702,895,268,1358,279,206,43,87,1783,2046,128,339,79 0.5683366593475094,-0.558403728184664,-0.0907134950668146,0.41529180787632924,1.4279535786684734,0.09468784334280253,1.402314093228658,1.6777690135569574,2.9065277890482055,2.321161071650228,-0.12517084870498654,-0.24767692023999524,2.0547236877093185,1.2590315225380515,2.3750691920218543 3430 Slc mediated transmembrane transport 12 20 2.9559861549767024 0.003116710811446 P12236,P55011,P11166,Q9UBX3,Q70HW3,P53985,P35613,P30825,Q8TB61,P12235,Q9Y6M7,Q15043 Processes and pathways Reactome Pathways msigdb_reactome 418,574,676,13,16,271,270,402,55,213,548,191 736,1567,676,213,418,3166,402,270,1641,271,574,191,950,2193,16,55,1552,1409,13,548 0.5833929390939195,-0.02250118346835699,0.6431811538013191,1.641034754600386,1.057143066123191,-1.1599171531024435,1.0981470112960925,1.4279535786684734,-0.0564914375226667,1.4279535786684734,0.7607169539788241,1.750489731196436,0.36847097049977656,-0.31905629408571334,3.2651743542921823,2.606176282501621,-0.005591913085313469,0.07811250742307049,3.391761695054266,0.8184979173823138 3430 Skin ulcer 10 34 2.9532618601010503 0.0031443510999606 O75874,O15269,P48735,O15270,P01889,Q03519,Q8IZA0,Q03518,Q14739,P04062 Drugs and Diseases Human Phenotype Ontology msigdb_hp 1,286,10,295,369,215,93,218,222,30 286,295,398,926,1776,3007,1,2743,1414,369,1534,30,2526,3340,2111,2778,10,1120,2623,2862,1450,218,215,741,2364,2045,1671,222,1821,2725,93,1046,2370,2472 1.3894476706931538,1.3636206339195902,1.1117439633053623,0.3841256925736641,-0.12517084870498654,-0.9510285615071858,3.92901774642917,-0.7116898323792509,0.06148252180205109,1.179204988513675,-0.005591913085313469,3.0603364192521147,-0.5395748804972572,-1.725900749051077,-0.2832385860448953,-0.7311921139115007,3.454011813127605,0.24146991514915547,-0.6153265492951593,-0.8099892376198776,0.04479749007284595,1.6287336796515217,1.641034754600386,0.5833929390939195,-0.40974773902190176,-0.24767692023999524,-0.07357327446040215,1.6164042064007391,-0.1424888753229872,-0.6922649775615227,2.2667166943530197,0.30536674022651894,-0.40974773902190176,-0.4835161673691688 3430 Exercise intolerance 6 32 2.9281307125563747 0.0034100665118215 P23786,P03886,Q9H2D1,Q9Y2R0,P12235,P00403 Drugs and Diseases Human Phenotype Ontology msigdb_hp 33,73,49,19,213,28 1951,28,3330,73,2819,2548,213,237,1475,33,2355,2576,1747,2990,948,2510,742,951,2197,920,2338,937,1325,49,816,1346,1350,1599,19,2024,1698,1601 -0.2123673195994045,3.0698107589013315,-1.6780491319681583,2.4178172840822203,-0.7704316844994457,-0.558403728184664,1.641034754600386,1.554325783520826,0.02805701137235168,3.0318170762153325,-0.40974773902190176,-0.5773048800496771,-0.10791253841717666,-0.9306276139125141,0.36847097049977656,-0.5208177336190014,0.5833929390939195,0.36847097049977656,-0.31905629408571334,0.3997325317718629,-0.3914762369552328,0.3841256925736641,0.1276761298241045,2.7383268943293446,0.4923857069491886,0.11120892157867891,0.11120892157867891,-0.02250118346835699,3.2192694624153164,-0.22999085661134913,-0.07357327446040215,-0.02250118346835699 3430 Tetratricopeptide-like helical domain superfamily [IPR011990] 22 94 2.927963176104345 0.0034119045157361 Q9UBV2,O15460,Q13042,Q8IYR2,Q6P2P2,Q9Y262,Q32P28,P13674,P49321,A0AVF1,Q9H7B4,Q6DKK2,Q13535,O75718,Q92791,P42345,Q96DB5,Q9Y6X3,O76024,Q6ZXV5,O00411,O75153 Sequence InterPro Superfamily interpro_homologous_superfamily 397,398,399,404,277,154,34,314,317,327,209,82,338,89,219,353,484,230,477,233,249,127 327,2173,868,249,1773,2767,398,2175,1809,1072,127,89,477,2069,1098,1533,2696,314,1030,2074,1416,353,1395,317,862,2079,2929,2553,2042,1783,1577,1967,2839,2087,1061,399,1335,2233,2722,338,2840,1788,1718,1618,2465,1858,3016,34,1036,82,277,2096,1491,480,233,2442,1586,995,404,2012,219,2566,1685,484,701,1044,2308,1658,2810,3093,2539,759,1273,1136,2735,3378,209,1593,1276,731,1985,397,1597,854,1468,689,3097,1557,154,1768,3317,2713,1007,230 1.2722190787348595,-0.31905629408571334,0.43080383738421585,1.5041368739934033,-0.12517084870498654,-0.7311921139115007,1.1117439633053623,-0.31905629408571334,-0.1424888753229872,0.2735187641595761,2.0547236877093185,2.2994483251380298,0.9321647887240839,-0.26542599868242417,0.25751962221115077,-0.005591913085313469,-0.6729168790091554,1.311585046538852,0.30536674022651894,-0.26542599868242417,0.06148252180205109,1.2192696206606266,0.07811250742307049,1.2984956621256847,0.44626893355334946,-0.26542599868242417,-0.8699343008139493,-0.558403728184664,-0.24767692023999524,-0.12517084870498654,-0.02250118346835699,-0.2123673195994045,-0.7901703605422196,-0.26542599868242417,0.2894676887918951,1.1117439633053623,0.11120892157867891,-0.33706243340680064,-0.6922649775615227,1.2590315225380515,-0.7901703605422196,-0.12517084870498654,-0.0907134950668146,-0.03946755021715677,-0.4835161673691688,-0.15986707294579158,-0.9510285615071858,3.0318170762153325,0.30536674022651894,2.342788021416518,1.4151493408700357,-0.26542599868242417,0.02805701137235168,0.9321647887240839,1.5792439505261,-0.4649705794159142,-0.02250118346835699,0.33701658189477507,1.0981470112960925,-0.22999085661134913,1.6287336796515217,-0.558403728184664,-0.07357327446040215,0.9321647887240839,0.6282990804246098,0.30536674022651894,-0.373271876429598,-0.0564914375226667,-0.7507725016906376,-1.0335027512907717,-0.5395748804972572,0.5683366593475094,0.1604504658814682,0.24146991514915547,-0.6922649775615227,-1.9981963448778324,1.6777690135569574,-0.02250118346835699,0.1604504658814682,0.5984052493734849,-0.2123673195994045,1.125305736257329,-0.02250118346835699,0.4616874064468927,0.04479749007284595,0.6431811538013191,-1.0335027512907717,-0.005591913085313469,1.8930410423267858,-0.10791253841717666,-1.5605037593216007,-0.6729168790091554,0.33701658189477507,1.5916594876052144 3430 Lipid transporter activity 13 23 2.927119276092467 0.0034211764690883 P08183,P30536,Q4KMQ2,P17900,O14678,Q9BZF1,P61916,O14975,Q96SU4,O15118,Q14849,P22059,Q96GC9 Functions GO Molecular function msigdb_gomf 159,2,163,66,257,458,512,424,564,109,27,316,188 2796,257,424,109,159,676,66,316,555,2,1914,512,2648,27,163,2193,730,188,564,1591,1553,458,3380 -0.7507725016906376,1.4661818634308703,1.04340337414266,2.1784605959005607,1.8695432160167267,0.6431811538013191,2.4918352621956807,1.2984956621256847,0.7896879996375533,3.92901774642917,-0.1948058268211105,0.8756421363992508,-0.6344483133432426,3.0792691433168833,1.8577557582221775,-0.31905629408571334,0.5984052493734849,1.7625145060761207,0.7896879996375533,-0.02250118346835699,-0.005591913085313469,0.9741576934609325,-2.049460345691425 3430 secondary carrier transporter 12 15 2.915082119450964 0.0035559496214603 O75746,P55011,Q96ES6,O14975,Q9UBX3,Q9UJS0,Q9BXP2,O95202,Q8TB61,Q9Y6M7,Q9BQT8,Q15043 Functions Panther Protein class panther_protein_class 692,574,37,424,13,708,601,401,55,548,157,191 424,692,401,574,696,191,2193,55,37,157,601,1409,13,708,548 1.04340337414266,0.6282990804246098,1.0981470112960925,0.7607169539788241,0.6282990804246098,1.750489731196436,-0.31905629408571334,2.606176282501621,3.0222783212407616,1.8813049364421908,0.7315827923762055,0.07811250742307049,3.391761695054266,0.6282990804246098,0.8184979173823138 3430 Abnormal joint morphology 57 288 2.914722936401714 0.0035600443992787 Q7LGA3,P38435,P10321,O15460,P51571,P06280,O95202,Q6DKJ4,Q15392,P21964,P08236,P04062,Q86XL3,O75844,P23786,P49902,O15269,O95831,P07602,P37268,Q99567,P16278,O15270,Q9Y619,Q9Y487,P50402,Q15427,Q9Y4P3,Q9NZ08,Q14108,Q15043,P42858,Q6NUQ1,P42892,Q9NZJ7,Q9UL01,Q96L58,Q13535,Q96PU5,O96028,O75718,Q8IZA0,Q14739,Q96AY3,Q96RL7,P16435,P48651,Q6ZXV5,P01889,Q9UHX1,Q9Y584,Q96HY6,Q96A33,Q13510,Q9NR77,O60568,Q14738 Drugs and Diseases Human Phenotype Ontology msigdb_hp 128,136,393,398,403,275,401,406,23,280,279,30,161,32,33,160,286,414,38,166,42,43,295,45,175,431,312,313,185,60,191,447,452,69,341,79,339,338,211,334,89,93,222,357,358,231,360,233,369,118,119,380,379,250,123,376,254 2173,1472,2026,3401,1389,1437,2107,977,2816,1438,1738,286,295,3322,454,398,2174,3060,2350,837,2283,2217,376,605,2143,1776,2594,2410,1356,2284,2574,1010,566,89,3248,32,2070,2947,1777,2179,401,2223,927,2502,3286,414,3151,334,2618,369,1534,858,30,1877,275,3232,2819,1254,3082,38,279,2548,393,1189,1255,1256,3046,3340,1223,1538,1743,43,231,2109,3303,896,1880,1415,3127,2073,693,280,2859,3163,2457,33,2262,2772,738,2287,2800,3049,1747,1813,2775,2413,2149,804,166,2078,136,2748,2620,2111,447,69,1884,3402,2749,360,677,796,2967,2039,160,431,2002,2079,1363,403,2509,1612,524,1100,1712,986,2670,821,574,2387,1290,3129,1544,1195,2862,2083,1014,2043,2992,2672,2555,1815,2879,1198,1450,2934,1296,807,1227,2364,1165,2511,2556,2608,2045,1921,2626,250,338,2235,1670,60,3275,2113,254,222,2091,1486,542,1398,713,1488,191,2299,1821,1078,23,312,1169,2562,1375,1676,822,2725,406,2051,452,2976,2845,233,128,2677,2302,161,919,996,93,933,2010,2276,1040,1079,1080,482,2565,639,1833,1523,1043,2729,2422,3346,2338,2120,1834,1378,379,1624,357,2873,1000,2308,380,685,339,211,358,2312,42,779,2123,2124,1087,1463,1242,2279,2540,1048,1730,1138,2370,1763,3424,850,1944,3371,2983,2521,2963,123,1903,2022,2472,185,341,1023,632,750,118,866,79,2875,855,3097,1349,2139,2066,2712,3241,2170,1470,1633,634,2917,2896,1436,2025,3213,175,313,1847,119,2741,1698,2281,3388,45,2172 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3430 Elevated pulmonary artery pressure 13 26 2.9061965659014675 0.003658515424751 O75844,Q6NUK1,P51970,O14678,O96000,P03886,P51798,P14854,P01889,Q8IZA0,Q14108,P00403,P04062 Drugs and Diseases Human Phenotype Ontology msigdb_hp 32,580,386,257,606,73,524,363,369,93,60,28,30 257,2145,32,606,28,369,1534,73,30,1255,363,1119,3127,2073,2925,2000,524,386,60,680,2676,580,93,1624,2132,3043 1.4661818634308703,-0.30111518243997987,3.050846065270086,0.7169539114401163,3.0698107589013315,1.179204988513675,-0.005591913085313469,2.4178172840822203,3.0603364192521147,0.1604504658814682,1.1925938145223307,0.24146991514915547,-1.096295452188383,-0.26542599868242417,-0.8699343008139493,-0.22999085661134913,0.861414936766202,1.1388325289942267,2.5336885717746562,0.6431811538013191,-0.6536448751928122,0.7607169539788241,2.2667166943530197,-0.03946755021715677,-0.2832385860448953,-0.971515740451046 3430 Sphingolipid pathway 6 8 2.906129076627265 0.0036593046418502 Q06136,O15269,O95470,Q13510,Q96G23,P04062 Processes and pathways WikiPathways msigdb_wp 258,286,86,250,124,30 286,295,86,30,1751,258,250,124 1.3894476706931538,1.3636206339195902,2.321161071650228,3.0603364192521147,-0.10791253841717666,1.4661818634308703,1.5041368739934033,2.066089721766653 3430 Endopeptidase activity 17 65 2.902160437490501 0.003705986876092 Q8TCT9,Q99797,O14773,O75844,Q10713,Q2T9J0,O43292,P42892,P28072,P67812,P49721,Q4J6C6,Q5JRX3,Q6P179,Q9NZ08,Q9BYT8,Q96K76 Functions GO Molecular function msigdb_gomf 289,290,162,32,292,320,194,69,199,173,142,371,85,407,185,349,255 162,194,800,1532,32,3215,3082,2857,2148,3257,437,984,3164,2287,199,1881,2227,2641,804,1710,820,69,2150,1448,2460,142,1417,2700,3318,1613,1642,173,292,1857,2048,637,2751,1517,320,371,85,2368,597,407,901,1861,1020,289,612,1083,1684,1834,1269,255,2310,1303,2098,290,2887,349,185,1093,1095,2452,1025 1.8577557582221775,1.738437938975464,0.4923857069491886,-0.005591913085313469,3.050846065270086,-1.267862233870033,-1.0335027512907717,-0.8099892376198776,-0.30111518243997987,-1.3782981393570042,1.0158151806848401,0.33701658189477507,-1.1599171531024435,-0.373271876429598,1.7263589960332117,-0.1773059016141884,-0.33706243340680064,-0.6344483133432426,0.4923857069491886,-0.0907134950668146,0.47705956297724367,2.4496613605694386,-0.30111518243997987,0.04479749007284595,-0.4835161673691688,1.9629265380559953,0.06148252180205109,-0.6729168790091554,-1.58377988008682,-0.03946755021715677,-0.0564914375226667,1.8222377186127818,1.3765499068522848,-0.15986707294579158,-0.24767692023999524,0.6875712647067221,-0.7116898323792509,0.01126068031324202,1.2984956621256847,1.179204988513675,2.3319852246797077,-0.40974773902190176,0.7315827923762055,1.0845146796370766,0.41529180787632924,-0.15986707294579158,0.32121625895525563,1.3894476706931538,0.7169539114401163,0.2735187641595761,-0.07357327446040215,-0.1424888753229872,0.1604504658814682,1.4915153034770001,-0.373271876429598,0.14408985151272588,-0.26542599868242417,1.3894476706931538,-0.8298890333091614,1.2458108826688405,1.774512395985724,0.2735187641595761,0.2735187641595761,-0.4649705794159142,0.32121625895525563 3430 Subcutaneous nodule 6 17 2.889367842091524 0.003860172284279 O75874,P48735,P35637,P06280,Q9NZ08,Q13510 Drugs and Diseases Human Phenotype Ontology msigdb_hp 1,10,235,275,185,250 1,369,858,275,1535,693,1190,235,10,796,1120,1450,2556,250,1903,185,1470 3.92901774642917,1.179204988513675,0.44626893355334946,1.4151493408700357,-0.005591913085313469,0.6282990804246098,0.19301386899346543,1.5667994320520733,3.454011813127605,0.5076661391022604,0.24146991514915547,0.04479749007284595,-0.558403728184664,1.5041368739934033,-0.1773059016141884,1.774512395985724,0.04479749007284595 3430 Lipid metabolism 53 135 2.889188970272184 0.0038623688898777 Q06136,O76062,Q53GQ0,P61916,Q9NP80,O14734,O00767,Q06520,Q8NCG7,Q15392,Q96K12,O15254,P04062,P23786,O15269,Q8N2A8,P07602,P37268,Q9P035,O14975,O15270,O95864,Q8NHP8,A1L0T0,O75477,Q96N66,Q15067,P17900,Q709F0,P54646,Q9NWU1,Q99519,Q16850,O75845,O95470,Q9H7Z7,Q15800,Q8NCC3,Q9NPH0,Q14739,Q9UG56,P48651,Q13510,Q9NUQ2,P51648,Q9UBM7,O15118,P27544,Q8NF37,Q16836,P35610,Q96G23,Q9NZ01 Processes and pathways Protein Atlas Biological process protein_atlas_biological_process 258,382,262,512,264,391,644,144,534,23,283,285,30,33,286,164,38,166,294,424,295,554,53,54,566,189,319,66,457,75,590,340,210,470,86,474,88,91,94,222,487,360,250,367,110,632,109,501,506,625,252,124,641 54,1184,2986,3427,644,391,424,109,285,286,295,1161,566,2694,470,382,2070,3323,86,1144,554,1876,30,3421,38,3287,2480,3358,3415,2697,1444,66,2504,1997,33,2354,2434,501,3344,3011,1318,928,252,166,2078,2183,948,740,929,2776,1884,2802,753,360,796,1258,1058,1364,110,1194,1855,3383,1013,75,2510,2081,512,2837,2607,3312,258,144,1968,1969,3423,250,2234,3254,222,3413,319,2391,3220,1016,23,1169,88,625,210,3291,1401,262,1170,2193,823,457,1128,164,1494,1623,91,534,506,53,663,717,124,283,189,340,1837,1085,1086,3422,904,3403,2128,1659,474,264,94,2065,2342,367,590,641,294,632,487,2135,760,1386,2660,1024,2172 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3430 Serine hydrolase activity 10 18 2.8867710440924146 0.0038921734580394 Q2T9J0,O14773,P10619,Q9HB40,Q9H3G5,P67812,P42785,Q4J6C6,Q5JRX3,O75976 Functions GO Molecular function msigdb_gomf 320,162,226,40,331,173,207,371,85,567 162,567,226,2857,2227,804,207,1448,1033,173,1517,320,371,85,597,1064,331,40 1.8577557582221775,0.7752227411673067,1.6040461907838122,-0.8099892376198776,-0.33706243340680064,0.4923857069491886,1.6777690135569574,0.04479749007284595,0.30536674022651894,1.8222377186127818,0.01126068031324202,1.2984956621256847,1.179204988513675,2.3319852246797077,0.7315827923762055,0.2894676887918951,1.2722190787348595,2.983960149974089 3430 Dysmetria 13 58 2.884373593050066 0.0039219317550849 O43292,O14773,Q10713,Q9NPL8,Q9NP80,Q6P4A7,Q06787,O75503,Q99519,Q6DKK2,Q5JRX3,Q9Y4P3,Q8IV08 Drugs and Diseases Human Phenotype Ontology msigdb_hp 194,162,292,325,264,232,203,104,340,82,85,313,120 2346,162,1438,794,194,2350,375,763,1532,104,3082,1569,1446,2073,1478,2775,1074,1961,2361,1713,2879,203,292,2045,550,3071,1582,2299,85,2842,82,2786,232,1235,120,933,1493,1494,1685,582,1001,1303,340,1212,2018,3188,264,325,2101,2102,1529,975,866,3097,1436,313,1025,2741 -0.40974773902190176,1.8577557582221775,0.04479749007284595,0.5076661391022604,1.738437938975464,-0.40974773902190176,1.1657819605638418,0.5532361269354006,-0.005591913085313469,2.189571052524327,-1.0335027512907717,-0.02250118346835699,0.04479749007284595,-0.26542599868242417,0.02805701137235168,-0.7311921139115007,0.2735187641595761,-0.2123673195994045,-0.40974773902190176,-0.0907134950668146,-0.8298890333091614,1.7021191193583658,1.3765499068522848,-0.24767692023999524,0.8041129767098191,-1.0127520150653435,-0.02250118346835699,-0.373271876429598,2.3319852246797077,-0.7901703605422196,2.342788021416518,-0.7311921139115007,1.5792439505261,0.17675834803240076,2.1000456604552045,0.3841256925736641,0.02805701137235168,0.02805701137235168,-0.07357327446040215,0.7607169539788241,0.33701658189477507,0.14408985151272588,1.2590315225380515,0.19301386899346543,-0.22999085661134913,-1.1813127889529935,1.4534696782308594,1.2853737321434007,-0.26542599868242417,-0.26542599868242417,0.01126068031324202,0.3527680424371989,0.44626893355334946,-1.0335027512907717,0.06148252180205109,1.3246420617522143,0.32121625895525563,-0.6922649775615227 3430 Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 7 18 2.884130567705939 0.003924959806661 O43852,O76024,Q9BTY2,P14625,P05067,Q02818,Q07065 Processes and pathways Reactome Pathways msigdb_reactome 321,477,202,300,205,246,253 321,477,205,1284,1953,1255,1536,300,2619,246,253,503,1335,2236,1373,1375,1621,202 1.2853737321434007,0.9321647887240839,1.6777690135569574,0.14408985151272588,-0.2123673195994045,0.1604504658814682,-0.005591913085313469,1.3506596827179598,-0.6153265492951593,1.5167285531774126,1.4915153034770001,0.8898304908049921,0.11120892157867891,-0.33706243340680064,0.09468784334280253,0.09468784334280253,-0.03946755021715677,1.7142527679704935 3430 Proton transmembrane transporter activity 13 35 2.881324504100599 0.0039600769684409 Q96ES6,P24539,P08574,Q9UDW1,Q9Y487,O75964,P14854,Q13423,P13073,Q00325,P12235,Q93050,P00403 Functions GO Molecular function msigdb_gomf 37,138,296,74,175,47,363,146,336,214,213,220,28 3081,47,401,28,736,674,296,840,213,336,363,1119,3191,3343,138,2925,784,1257,2149,2748,1075,3379,2080,726,1259,214,146,525,220,37,1409,74,2136,175,2067 -1.0335027512907717,2.748363067010926,1.0981470112960925,3.0698107589013315,0.5833929390939195,0.6431811538013191,1.3636206339195902,0.4616874064468927,1.641034754600386,1.2590315225380515,1.1925938145223307,0.24146991514915547,-1.2028041638743916,-1.7500104946959263,1.9744867066455778,-0.8699343008139493,0.522901157152449,0.1604504658814682,-0.30111518243997987,-0.7116898323792509,0.2735187641595761,-2.0237575733036444,-0.26542599868242417,0.5984052493734849,0.1604504658814682,1.641034754600386,1.9280968875332776,0.861414936766202,1.6287336796515217,3.0222783212407616,0.07811250742307049,2.4178172840822203,-0.2832385860448953,1.8103460646896083,-0.24767692023999524 3430 Establishment of protein localization to organelle 45 186 2.8787158084869504 0.0039929797853985 Q99623,P30536,P46379,P52789,Q8TB36,Q9NS69,P11279,O60830,Q9Y512,Q5SRE5,Q9UGP8,P35658,Q9P0J0,O95831,Q99797,Q10713,O14737,Q7Z3B4,Q99567,O43681,Q15070,Q9Y5J7,Q14108,O43615,Q9Y5J9,O60684,P55786,O15397,O14925,Q99595,Q92973,Q5JRX3,Q99523,Q8N1F7,Q9Y2T2,Q8N4H5,Q96RL7,P46934,Q9HD47,Q9Y5M8,P13473,Q15629,P52294,Q9Y584,Q9Y5L4 Processes and pathways GO Biological process msigdb_gobp 517,2,256,510,390,7,646,20,278,662,547,657,158,414,290,292,165,559,42,553,181,571,60,565,193,198,575,328,204,78,208,85,600,611,617,101,358,103,106,236,237,116,117,119,125 2173,2026,1248,1437,1908,1116,2347,165,2348,204,907,328,565,553,1809,198,20,1776,2410,2284,1056,1532,979,2069,1098,2322,1251,2898,803,3286,414,1443,1534,1877,1608,656,1285,1508,2965,3180,2108,982,646,1706,237,1538,2858,1880,2260,1147,3127,2073,2505,2,1999,3218,657,2642,1572,3145,2111,739,256,103,2778,677,2151,2184,1915,862,2040,2079,3270,2508,1364,694,966,117,510,1033,1418,575,1195,3390,2930,2862,1149,1014,2267,2416,2577,2673,1644,2511,988,292,1857,2418,2824,60,2806,1372,3183,877,1488,181,900,116,2190,1452,3016,968,951,85,662,2051,2393,1586,559,2868,1827,1127,1795,2160,611,101,390,970,1833,1236,1977,208,2424,2204,358,793,885,600,42,1272,78,517,290,1462,1759,2062,1046,2912,886,889,1730,2685,1688,3003,1867,106,2207,7,2570,2496,158,1735,3307,1767,547,1053,2687,1385,1114,1386,2522,2894,2875,1845,3042,2403,1350,617,3222,278,119,571,193,2815,125,236 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3430 Molecular transducer activity 11 34 2.877562057558247 0.0040076107593234 P30536,O15173,O14786,Q8WTV0,Q9BUN8,O15118,Q15629,Q9Y6I9,Q99720,Q14108,Q9UGP8 Functions GO Molecular function msigdb_gomf 2,99,520,169,366,109,116,572,26,60,547 520,945,109,99,1607,1221,873,1509,1147,2,2111,3289,796,2904,2364,1578,60,116,950,1674,2754,169,1656,882,793,600,26,366,1245,2497,2343,547,1279,572 0.861414936766202,0.36847097049977656,2.1784605959005607,2.211724229893288,-0.03946755021715677,0.17675834803240076,0.43080383738421585,0.01126068031324202,0.22536929144369766,3.92901774642917,-0.2832385860448953,-1.4913543909405875,0.5076661391022604,-0.8498704751461239,-0.40974773902190176,-0.02250118346835699,2.5336885717746562,2.133790611209967,0.36847097049977656,-0.07357327446040215,-0.7116898323792509,1.8459424393187207,-0.0564914375226667,0.43080383738421585,0.522901157152449,0.7315827923762055,3.107549151128594,1.1925938145223307,0.17675834803240076,-0.5021316919187672,-0.3914762369552328,0.8184979173823138,0.1604504658814682,0.7752227411673067 3430 Mitochondrial calcium ion transport 6 15 2.8753814426043927 0.0040353966240684 Q10713,P21796,P45880,Q9Y277,O95202,Q8IYU8 Processes and pathways Reactome Pathways msigdb_reactome 292,9,15,309,401,347 1532,401,9,1781,15,292,347,1130,1236,1324,1303,517,1530,309,1025 -0.005591913085313469,1.0981470112960925,3.489279818123242,-0.12517084870498654,3.2925394092933984,1.3765499068522848,1.2458108826688405,0.24146991514915547,0.17675834803240076,0.1276761298241045,0.14408985151272588,0.8756421363992508,0.01126068031324202,1.3376668826640072,0.32121625895525563 3430 Abnormal retinal vascular morphology 13 51 2.8747164516940944 0.0040439048115143 P17900,P10619,P07602,P38435,P03886,P16278,Q9NZJ7,Q99519,P06865,P04439,Q9Y4P3,Q13510,P21964 Drugs and Diseases Human Phenotype Ontology msigdb_hp 66,226,38,136,73,43,341,340,268,244,313,250,280 2406,1472,1328,1439,2350,961,1874,413,1638,2818,1533,3045,73,244,268,38,1358,3189,226,2856,2878,43,66,2073,693,280,1747,1190,2775,3068,2357,136,2801,1543,2991,2670,2879,696,250,2299,1374,744,2057,1131,2422,1156,792,340,341,866,313 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3430 Hypertrophic cardiomyopathy 28 116 2.871432832617573 0.0040861560821219 Q9H061,Q96CU9,Q13423,P06280,O43676,P00403,Q9P0J0,O75306,Q99797,P53701,Q86Y39,P16278,P50402,Q9Y4P3,P10253,Q9NVI7,Q9Y6M9,Q9NPL8,P03886,O15360,P15586,P54802,P12235,Q00325,P13473,P14854,P01889,O60313 Drugs and Diseases Human Phenotype Ontology msigdb_hp 12,274,146,275,21,28,158,413,290,167,168,43,431,313,311,443,326,325,73,454,206,87,213,214,237,363,369,375 2173,892,1950,454,21,2922,2350,1142,375,1441,413,978,1442,3248,1390,2033,3286,606,28,369,1534,73,858,275,1566,2035,723,1117,1568,311,213,237,363,206,43,3010,3029,2639,2073,693,3031,3011,1747,1478,2775,2413,2078,2748,948,1395,2507,1075,1258,3152,431,1058,2483,167,87,1290,3360,2992,2879,1034,2484,214,2934,2556,146,1670,3275,2113,2299,1673,625,3132,951,1262,822,626,525,168,1493,935,2872,1043,1459,1624,274,972,1837,290,3041,1087,2518,1242,1942,12,1408,3262,816,1660,3371,325,2022,443,2133,749,158,866,1350,488,2024,2025,313,326 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3430 Abnormal bone structure 42 188 2.867530127002643 0.004136894156147 O75874,P61978,P38435,P48735,P06280,O95202,Q15392,P08236,P04062,Q86XL3,O75844,O95831,Q32P28,P07602,P16278,Q13277,Q9Y619,Q9Y487,Q9NWM8,O15228,Q9Y4P3,P42695,Q14108,Q15043,O43292,O15360,Q9NZJ7,Q99519,Q96L58,O75845,O96028,P54802,P12235,O75718,P22626,Q14739,Q96AY3,P48651,Q13126,Q96HY6,Q13510,O60568 Drugs and Diseases Human Phenotype Ontology msigdb_hp 1,387,136,10,275,401,23,279,30,161,32,414,34,38,43,427,45,175,179,307,313,439,60,191,194,454,341,340,339,470,334,87,213,89,343,222,357,360,113,380,250,376 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3430